diff --git a/minerva-core/src/main/java/org/geneontology/minerva/BlazegraphOntologyManager.java b/minerva-core/src/main/java/org/geneontology/minerva/BlazegraphOntologyManager.java index bff7a13f..d012db49 100644 --- a/minerva-core/src/main/java/org/geneontology/minerva/BlazegraphOntologyManager.java +++ b/minerva-core/src/main/java/org/geneontology/minerva/BlazegraphOntologyManager.java @@ -35,18 +35,7 @@ import org.openrdf.rio.RDFParseException; import org.openrdf.rio.helpers.StatementCollector; import org.semanticweb.owlapi.apibinding.OWLManager; -import org.semanticweb.owlapi.model.IRI; -import org.semanticweb.owlapi.model.OWLAnnotation; -import org.semanticweb.owlapi.model.OWLAnnotationProperty; -import org.semanticweb.owlapi.model.OWLAxiom; -import org.semanticweb.owlapi.model.OWLClass; -import org.semanticweb.owlapi.model.OWLClassExpression; -import org.semanticweb.owlapi.model.OWLDataFactory; -import org.semanticweb.owlapi.model.OWLNamedIndividual; -import org.semanticweb.owlapi.model.OWLNamedObject; -import org.semanticweb.owlapi.model.OWLOntology; -import org.semanticweb.owlapi.model.OWLOntologyCreationException; -import org.semanticweb.owlapi.model.OWLOntologyManager; +import org.semanticweb.owlapi.model.*; import org.semanticweb.owlapi.rio.RioRenderer; import org.semanticweb.owlapi.search.EntitySearcher; import org.semarglproject.vocab.OWL; @@ -397,14 +386,16 @@ public Map> getSuperCategoryMapForIndividuals(Se Map> ind_roots = new HashMap>(); Set all_types = new HashSet(); Map> ind_types = new HashMap>(); - for(OWLNamedIndividual ind : inds) { + for (OWLNamedIndividual ind : inds) { Set types = new HashSet(); for(OWLClassExpression oc : EntitySearcher.getTypes(ind, ont)) { - if(!oc.isAnonymous()) { + if (oc.isNamed()) { types.add(oc.asOWLClass().getIRI().toString()); - all_types.addAll(types); + } else if (oc instanceof OWLObjectComplementOf) { + types.add(((OWLObjectComplementOf)oc).getOperand().asOWLClass().getIRI().toString()); } } + all_types.addAll(types); if(fix_deprecated) { ind_types.put(ind, replaceDeprecated(types)); }else { diff --git a/minerva-core/src/main/java/org/geneontology/minerva/model/GoCamModel.java b/minerva-core/src/main/java/org/geneontology/minerva/model/GoCamModel.java index 3d7531a5..2b0c5aca 100644 --- a/minerva-core/src/main/java/org/geneontology/minerva/model/GoCamModel.java +++ b/minerva-core/src/main/java/org/geneontology/minerva/model/GoCamModel.java @@ -60,27 +60,27 @@ public GoCamModel(OWLOntology abox, BlazegraphMolecularModelManager m3) throws I } private void setIndTypesWithSparql(BlazegraphMolecularModelManager m3, String graph_id) throws MalformedQueryException, QueryEvaluationException, RepositoryException, IOException { - Map> i_types = new HashMap>(); + Map> iTypesAndComplementTypes = new HashMap>(); Set all_types = new HashSet(); TupleQueryResult r = (TupleQueryResult) m3.executeSPARQLQuery("" + "PREFIX rdf: " + "select ?instance ?type where {" + "GRAPH <"+graph_id+"> { " + "?instance rdf:type ." - + "?instance rdf:type ?type ." - + "filter (?type != ) " + + "{ ?instance rdf:type ?type . } UNION { ?instance rdf:type ?complement . ?complement owl:complementOf ?type . }" + + "FILTER (isIRI(?type)) " + + "FILTER (?type != ) " + "}}", 100); while(r.hasNext()) { BindingSet bs = r.next(); String instance = bs.getBinding("instance").getValue().stringValue(); String type = bs.getBinding("type").getValue().stringValue(); OWLNamedIndividual i = ont.getOWLOntologyManager().getOWLDataFactory().getOWLNamedIndividual(IRI.create(instance)); - Set types = i_types.get(i); - if(types==null) { - types = new HashSet(); + if (!iTypesAndComplementTypes.containsKey(i)) { + iTypesAndComplementTypes.put(i, new HashSet()); } + Set types = iTypesAndComplementTypes.get(i); types.add(type); - i_types.put(i, types); all_types.add(type); } r.close(); @@ -89,9 +89,9 @@ private void setIndTypesWithSparql(BlazegraphMolecularModelManager m3, String gr Map> type_roots = go_lego.getSuperCategoryMap(corrected_types); //set global ind_types = new HashMap>(); - for(OWLNamedIndividual ind : i_types.keySet()) { + for(OWLNamedIndividual ind : iTypesAndComplementTypes.keySet()) { //fix deprecated - Set types = go_lego.replaceDeprecated(i_types.get(ind), old_new); + Set types = go_lego.replaceDeprecated(iTypesAndComplementTypes.get(ind), old_new); //convert to root types Set roots = new HashSet(); for(String type : types) { diff --git a/minerva-core/src/test/java/org/geneontology/minerva/model/GoCamModelTest.java b/minerva-core/src/test/java/org/geneontology/minerva/model/GoCamModelTest.java index dc77344a..5bcc9d9a 100644 --- a/minerva-core/src/test/java/org/geneontology/minerva/model/GoCamModelTest.java +++ b/minerva-core/src/test/java/org/geneontology/minerva/model/GoCamModelTest.java @@ -1,9 +1,5 @@ package org.geneontology.minerva.model; -import static org.junit.Assert.*; - -import java.io.File; -import java.io.IOException; import org.geneontology.minerva.BlazegraphOntologyManager; import org.geneontology.minerva.ModelContainer; import org.geneontology.minerva.UndoAwareMolecularModelManager; @@ -12,92 +8,109 @@ import org.junit.AfterClass; import org.junit.BeforeClass; import org.junit.Test; -import org.openrdf.query.BindingSet; -import org.openrdf.query.MalformedQueryException; -import org.openrdf.query.QueryEvaluationException; -import org.openrdf.query.QueryResult; -import org.openrdf.query.TupleQueryResult; -import org.openrdf.repository.RepositoryException; -import org.openrdf.rio.RDFHandlerException; -import org.openrdf.rio.RDFParseException; import org.semanticweb.owlapi.apibinding.OWLManager; import org.semanticweb.owlapi.model.IRI; -import org.semanticweb.owlapi.model.OWLObjectProperty; import org.semanticweb.owlapi.model.OWLOntology; -import org.semanticweb.owlapi.model.OWLOntologyCreationException; import org.semanticweb.owlapi.model.OWLOntologyManager; +import java.io.File; + +import static org.junit.Assert.assertFalse; +import static org.junit.Assert.assertTrue; + public class GoCamModelTest { - static final String ontology_journal_file = "/tmp/test-go-lego-blazegraph.jnl"; - static final String gocam_dir = "src/test/resources/validation/model_test/"; - static BlazegraphOntologyManager onto_repo; + static final String ontology_journal_file = "/tmp/test-go-lego-blazegraph.jnl"; + static final String gocam_dir = "src/test/resources/validation/model_test/"; + static BlazegraphOntologyManager onto_repo; + + @BeforeClass + public static void setUpBeforeClass() throws Exception { - @BeforeClass - public static void setUpBeforeClass() throws Exception { + } - } + @AfterClass + public static void tearDownAfterClass() throws Exception { + if (onto_repo != null) { + onto_repo.dispose(); + } + } - @AfterClass - public static void tearDownAfterClass() throws Exception { - if(onto_repo!=null) { - onto_repo.dispose(); - } - } + @Test + public void testRootTypesForComplements() throws Exception { + String ontologyJournalFile = "/tmp/test-go-lego-blazegraph-complements.jnl"; + OWLOntologyManager man = OWLManager.createOWLOntologyManager(); + OWLOntology tboxOntology = man.loadOntologyFromOntologyDocument(new File("src/test/resources/go-basic.obo")); + CurieHandler curieHandler = new MappedCurieHandler(); + String inputDB = "/tmp/test-blazegraph-models-complements.jnl"; + UndoAwareMolecularModelManager m3 = null; + m3 = new UndoAwareMolecularModelManager(tboxOntology, curieHandler, "gomodel", inputDB, null, ontologyJournalFile, true); + m3.importModelToDatabase(new File("src/test/resources/test-complement-roots.ttl"), true); + ModelContainer mc = m3.getModel(IRI.create("http://model.geneontology.org/61f3310500000003")); + OWLOntology gocam_via_mc = mc.getAboxOntology(); + GoCamModel g = new GoCamModel(gocam_via_mc, m3); + assertTrue("Can get roots for classes and complements", + g.ind_types.get(man.getOWLDataFactory().getOWLNamedIndividual(IRI.create("http://model.geneontology.org/61f3310500000003/61f3310500000004"))) + .contains("http://purl.obolibrary.org/obo/GO_0008150")); + assertTrue("Can get roots for classes and complements", + g.ind_types.get(man.getOWLDataFactory().getOWLNamedIndividual(IRI.create("http://model.geneontology.org/61f3310500000003/61f3310500000005"))) + .contains("http://purl.obolibrary.org/obo/GO_0008150")); + m3.getGolego_repo().dispose(); + } - @Test - public void testGoModelStats() throws Exception { - OWLOntologyManager man = OWLManager.createOWLOntologyManager(); - OWLOntology tbox_ontology = man.loadOntology(IRI.create("http://purl.obolibrary.org/obo/go/extensions/go-lego.owl")); - CurieHandler curieHandler = new MappedCurieHandler(); - String inputDB = "/tmp/test-blazegraph-models.jnl"; + @Test + public void testGoModelStats() throws Exception { + OWLOntologyManager man = OWLManager.createOWLOntologyManager(); + OWLOntology tbox_ontology = man.loadOntology(IRI.create("http://purl.obolibrary.org/obo/go/extensions/go-lego.owl")); + CurieHandler curieHandler = new MappedCurieHandler(); + String inputDB = "/tmp/test-blazegraph-models.jnl"; //load it into a journal and launch an m3 - UndoAwareMolecularModelManager m3 = null; - File f = new File(gocam_dir); - if(f.isDirectory()) { - //remove anything that existed from previous runs - File bgdb = new File(inputDB); - if(bgdb.exists()) { - bgdb.delete(); - } - //set it up with empty db - m3 = new UndoAwareMolecularModelManager(tbox_ontology, curieHandler, "gomodel", inputDB, null, ontology_journal_file, true); - onto_repo = m3.getGolego_repo(); - //load the db - for(File file : f.listFiles()) { - if(file.getName().endsWith("ttl")) { - m3.importModelToDatabase(file, true); - } - } - } + UndoAwareMolecularModelManager m3 = null; + File f = new File(gocam_dir); + if (f.isDirectory()) { + //remove anything that existed from previous runs + File bgdb = new File(inputDB); + if (bgdb.exists()) { + bgdb.delete(); + } + //set it up with empty db + m3 = new UndoAwareMolecularModelManager(tbox_ontology, curieHandler, "gomodel", inputDB, null, ontology_journal_file, true); + onto_repo = m3.getGolego_repo(); + //load the db + for (File file : f.listFiles()) { + if (file.getName().endsWith("ttl")) { + m3.importModelToDatabase(file, true); + } + } + } //read it back out and check on stats - for(IRI modelIRI : m3.getAvailableModelIds()) { - ModelContainer mc = m3.getModel(modelIRI); - OWLOntology gocam_via_mc = mc.getAboxOntology(); - GoCamModel g = new GoCamModel(gocam_via_mc, m3); - //testing for an issue with the OWL blazegraph loader - assertFalse("title not read out of M3 retrieved model "+modelIRI, (g.getTitle()==null)); - //note these test cases from reactome contain some reactions that are not officially 'part of' the model - //these reactions are not counted as activities, but causal relations coming from them are counted. - if(modelIRI.toString().contains("R-HSA-5654719")) { - //SHC-mediated cascade:FGFR4 - assertTrue("wrong n activities "+g.getStats().n_activity_units, g.getStats().n_activity_units==4); - assertTrue("wrong n complete activities "+g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units==2); - assertTrue("wrong n unenabled activities "+g.getStats().n_no_enabler, g.getStats().n_no_enabler==2); - assertTrue("wrong n causal relations "+g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions==6); - }else if(modelIRI.toString().contains("R-HSA-201688")) { - //WNT mediated activation of DVL - assertTrue("wrong n activities "+g.getStats().n_activity_units, g.getStats().n_activity_units==4); - assertTrue("wrong n complete activities "+g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units==3); - assertTrue("wrong n unenabled activities "+g.getStats().n_no_enabler, g.getStats().n_no_enabler==1); - assertTrue("wrong n causal relations "+g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions==3); - }else if(modelIRI.toString().contains("R-HSA-5654733")) { - //Negative regulation of FGFR4 signaling - assertTrue("wrong n activities "+g.getStats().n_activity_units, g.getStats().n_activity_units==3); - assertTrue("wrong n complete activities "+g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units==2); - assertTrue("wrong n unenabled activities "+g.getStats().n_no_enabler, g.getStats().n_no_enabler==1); - assertTrue("wrong n causal relations "+g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions==3); - } - } - } + for (IRI modelIRI : m3.getAvailableModelIds()) { + ModelContainer mc = m3.getModel(modelIRI); + OWLOntology gocam_via_mc = mc.getAboxOntology(); + GoCamModel g = new GoCamModel(gocam_via_mc, m3); + //testing for an issue with the OWL blazegraph loader + assertFalse("title not read out of M3 retrieved model " + modelIRI, (g.getTitle() == null)); + //note these test cases from reactome contain some reactions that are not officially 'part of' the model + //these reactions are not counted as activities, but causal relations coming from them are counted. + if (modelIRI.toString().contains("R-HSA-5654719")) { + //SHC-mediated cascade:FGFR4 + assertTrue("wrong n activities " + g.getStats().n_activity_units, g.getStats().n_activity_units == 4); + assertTrue("wrong n complete activities " + g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units == 2); + assertTrue("wrong n unenabled activities " + g.getStats().n_no_enabler, g.getStats().n_no_enabler == 2); + assertTrue("wrong n causal relations " + g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions == 6); + } else if (modelIRI.toString().contains("R-HSA-201688")) { + //WNT mediated activation of DVL + assertTrue("wrong n activities " + g.getStats().n_activity_units, g.getStats().n_activity_units == 4); + assertTrue("wrong n complete activities " + g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units == 3); + assertTrue("wrong n unenabled activities " + g.getStats().n_no_enabler, g.getStats().n_no_enabler == 1); + assertTrue("wrong n causal relations " + g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions == 3); + } else if (modelIRI.toString().contains("R-HSA-5654733")) { + //Negative regulation of FGFR4 signaling + assertTrue("wrong n activities " + g.getStats().n_activity_units, g.getStats().n_activity_units == 3); + assertTrue("wrong n complete activities " + g.getStats().n_complete_activity_units, g.getStats().n_complete_activity_units == 2); + assertTrue("wrong n unenabled activities " + g.getStats().n_no_enabler, g.getStats().n_no_enabler == 1); + assertTrue("wrong n causal relations " + g.getStats().n_causal_in_relation_assertions, g.getStats().n_causal_in_relation_assertions == 3); + } + } + } } diff --git a/minerva-core/src/test/resources/go-basic.obo b/minerva-core/src/test/resources/go-basic.obo new file mode 100644 index 00000000..d0318e37 --- /dev/null +++ b/minerva-core/src/test/resources/go-basic.obo @@ -0,0 +1,541715 @@ +format-version: 1.2 +data-version: releases/2022-01-13 +subsetdef: chebi_ph7_3 "Rhea list of ChEBI terms representing the major species at pH 7.3." +subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" +subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" +subsetdef: goslim_agr "AGR slim" +subsetdef: goslim_aspergillus "Aspergillus GO slim" +subsetdef: goslim_candida "Candida GO slim" +subsetdef: goslim_chembl "ChEMBL protein targets summary" +subsetdef: goslim_drosophila "Drosophila GO slim" +subsetdef: goslim_flybase_ribbon "FlyBase Drosophila GO ribbon slim" +subsetdef: goslim_generic "Generic GO slim" +subsetdef: goslim_metagenomics "Metagenomics GO slim" +subsetdef: goslim_mouse "Mouse GO slim" +subsetdef: goslim_pir "PIR GO slim" +subsetdef: goslim_plant "Plant GO slim" +subsetdef: goslim_pombe "Fission yeast GO slim" +subsetdef: goslim_synapse "synapse GO slim" +subsetdef: goslim_yeast "Yeast GO slim" +synonymtypedef: syngo_official_label "label approved by the SynGO project" +synonymtypedef: systematic_synonym "Systematic synonym" EXACT +default-namespace: gene_ontology +ontology: go + +[Term] +id: GO:0000001 +name: mitochondrion inheritance +namespace: biological_process +def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] +synonym: "mitochondrial inheritance" EXACT [] +is_a: GO:0048308 ! organelle inheritance +is_a: GO:0048311 ! mitochondrion distribution + +[Term] +id: GO:0000002 +name: mitochondrial genome maintenance +namespace: biological_process +def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0000003 +name: reproduction +namespace: biological_process +alt_id: GO:0019952 +alt_id: GO:0050876 +def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_pir +subset: goslim_plant +synonym: "reproductive physiological process" EXACT [] +xref: Wikipedia:Reproduction +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0000005 +name: obsolete ribosomal chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] +comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. +synonym: "ribosomal chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0042254 +consider: GO:0044183 +consider: GO:0051082 + +[Term] +id: GO:0000006 +name: high-affinity zinc transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] +synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT [] +synonym: "high-affinity zinc uptake transmembrane transporter activity" RELATED [] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000007 +name: low-affinity zinc ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity + +[Term] +id: GO:0000008 +name: obsolete thioredoxin +namespace: molecular_function +alt_id: GO:0000013 +def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] +comment: This term was made obsolete because it represents gene products. +synonym: "thioredoxin" EXACT [] +is_obsolete: true +consider: GO:0003756 +consider: GO:0015036 + +[Term] +id: GO:0000009 +name: alpha-1,6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248] +synonym: "1,6-alpha-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.232 +xref: Reactome:R-HSA-449718 "Addition of a third mannose to the N-glycan precursor by ALG2" +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000010 +name: trans-hexaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [PMID:9708911, RHEA:20836] +xref: RHEA:20836 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0000011 +name: vacuole inheritance +namespace: biological_process +def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] +is_a: GO:0007033 ! vacuole organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0000012 +name: single strand break repair +namespace: biological_process +def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [PMID:18626472] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0000014 +name: single-stranded DNA endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] +synonym: "single-stranded DNA specific endodeoxyribonuclease activity" RELATED [] +synonym: "ssDNA-specific endodeoxyribonuclease activity" RELATED [GOC:mah] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0000015 +name: phosphopyruvate hydratase complex +namespace: cellular_component +def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] +subset: goslim_metagenomics +synonym: "enolase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0000016 +name: lactase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [PMID:12023280] +synonym: "lactose galactohydrolase activity" EXACT [] +xref: EC:3.2.1.108 +xref: MetaCyc:LACTASE-RXN +xref: Reactome:R-HSA-189062 "lactose + H2O => D-glucose + D-galactose" +xref: Reactome:R-HSA-5658001 "Defective LCT does not hydrolyze Lac" +xref: RHEA:10076 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0000017 +name: alpha-glucoside transport +namespace: biological_process +def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, ISBN:0198506732, PMID:9919658] +is_a: GO:0042946 ! glucoside transport + +[Term] +id: GO:0000018 +name: regulation of DNA recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0000019 +name: regulation of mitotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] +synonym: "regulation of recombination within rDNA repeats" NARROW [] +is_a: GO:0000018 ! regulation of DNA recombination +relationship: regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0000020 +name: obsolete negative regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] +comment: This term was made obsolete because it describes a substrate-specific process. +synonym: "negative regulation of recombination within rDNA repeats" EXACT [] +is_obsolete: true +consider: GO:0045950 + +[Term] +id: GO:0000022 +name: mitotic spindle elongation +namespace: biological_process +alt_id: GO:1905121 +def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw, PMID:19686686] +synonym: "microtubule sliding involved in mitotic spindle elongation" RELATED [] +synonym: "spindle elongation during mitosis" EXACT [] +is_a: GO:0051231 ! spindle elongation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation +relationship: part_of GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0000023 +name: maltose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732] +synonym: "malt sugar metabolic process" EXACT [] +synonym: "malt sugar metabolism" EXACT [] +synonym: "maltose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0000024 +name: maltose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] +synonym: "malt sugar biosynthesis" EXACT [] +synonym: "malt sugar biosynthetic process" EXACT [] +synonym: "maltose anabolism" EXACT [] +synonym: "maltose biosynthesis" EXACT [] +synonym: "maltose formation" EXACT [] +synonym: "maltose synthesis" EXACT [] +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0000025 +name: maltose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] +synonym: "malt sugar catabolic process" EXACT [] +synonym: "malt sugar catabolism" EXACT [] +synonym: "maltose breakdown" EXACT [] +synonym: "maltose degradation" EXACT [] +synonym: "maltose hydrolysis" NARROW [] +xref: MetaCyc:MALTOSECAT-PWY +is_a: GO:0000023 ! maltose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0000026 +name: alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541] +xref: Reactome:R-HSA-446187 "ALG11 transfers the fourth and fifth Man to the N-glycan precursor" +xref: Reactome:R-HSA-446215 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1" +xref: Reactome:R-HSA-446216 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1" +xref: Reactome:R-HSA-4551297 "Defective ALG11 does not transfer Man to the N-glycan precursor" +xref: Reactome:R-HSA-4720478 "Defective ALG9 does not add the seventh mannose to the N-glycan precursor" +xref: Reactome:R-HSA-9035514 "Defective ALG9 does not add the last mannose to the N-glycan precursor" +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000027 +name: ribosomal large subunit assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] +synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah] +synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0042255 ! ribosome assembly +relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis + +[Term] +id: GO:0000028 +name: ribosomal small subunit assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] +synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah] +synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0042255 ! ribosome assembly +relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis + +[Term] +id: GO:0000030 +name: mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm] +xref: Reactome:R-HSA-162797 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" +xref: Reactome:R-HSA-162830 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate" +xref: Reactome:R-HSA-446198 "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1" +xref: Reactome:R-HSA-4720497 "Defective ALG12 does not add mannose to the N-glycan precursor" +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0000031 +name: mannosylphosphate transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0000032 +name: cell wall mannoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai] +synonym: "cell wall mannoprotein anabolism" EXACT [] +synonym: "cell wall mannoprotein biosynthesis" EXACT [] +synonym: "cell wall mannoprotein formation" EXACT [] +synonym: "cell wall mannoprotein synthesis" EXACT [] +is_a: GO:0006057 ! mannoprotein biosynthetic process +is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process + +[Term] +id: GO:0000033 +name: alpha-1,3-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541] +xref: Reactome:R-HSA-446188 "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1" +xref: Reactome:R-HSA-446208 "Addition of a second mannose to the N-glycan precursor by ALG2" +xref: Reactome:R-HSA-4549368 "Defective ALG2 does not transfer a second Man to N-glycan precursor" +xref: Reactome:R-HSA-4720473 "Defective ALG3 does not add mannose to the N-glycan precursor" +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0000034 +name: adenine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] +synonym: "ADase activity" RELATED [EC:3.5.4.2] +synonym: "adenase activity" RELATED [EC:3.5.4.2] +synonym: "adenine aminase activity" RELATED [EC:3.5.4.2] +synonym: "adenine aminohydrolase activity" RELATED [EC:3.5.4.2] +xref: EC:3.5.4.2 +xref: MetaCyc:ADENINE-DEAMINASE-RXN +xref: RHEA:23688 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0000035 +name: acyl binding +namespace: molecular_function +def: "Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732] +synonym: "acyl-CoA or acyl binding" BROAD [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0000036 +name: acyl carrier activity +namespace: molecular_function +def: "Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis." [GOC:jl, GOC:vw] +synonym: "ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process" EXACT [] +is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding +is_a: GO:0140414 ! phosphopantetheine-dependent carrier activity + +[Term] +id: GO:0000038 +name: very long-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22." [GOC:hjd] +synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf] +synonym: "very-long-chain fatty acid metabolic process" EXACT [] +synonym: "very-long-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0000039 +name: obsolete plasma membrane long-chain fatty acid transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and it contains component information. +synonym: "plasma membrane long-chain fatty acid transporter" EXACT [] +is_obsolete: true +consider: GO:0005324 +consider: GO:0005886 + +[Term] +id: GO:0000041 +name: transition metal ion transport +namespace: biological_process +def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] +synonym: "transition metal transport" EXACT [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0000044 +name: obsolete ascorbate stabilization +namespace: biological_process +def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] +comment: This term was made obsolete because it is defined as a function term and is in the process ontology. +synonym: "ascorbate stabilization" EXACT [] +synonym: "vitamin C stabilization" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000045 +name: autophagosome assembly +namespace: biological_process +def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] +synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] +synonym: "autophagic vacuole formation" RELATED [GOC:mah] +synonym: "autophagosome biosynthesis" EXACT [] +synonym: "autophagosome formation" EXACT [] +synonym: "PAS formation" NARROW [] +is_a: GO:0070925 ! organelle assembly +is_a: GO:1905037 ! autophagosome organization + +[Term] +id: GO:0000047 +name: obsolete Rieske iron-sulfur protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "Rieske iron-sulfur protein" EXACT [] +synonym: "Rieske iron-sulphur protein" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0000048 +name: peptidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [PMID:11433365, PMID:9242921] +synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" RELATED [] +xref: EC:2.3.2.12 +xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN +xref: Reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA" +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0000049 +name: tRNA binding +namespace: molecular_function +alt_id: GO:0000946 +def: "Binding to a transfer RNA." [GOC:ai] +synonym: "base pairing with tRNA" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0000050 +name: urea cycle +namespace: biological_process +alt_id: GO:0006594 +alt_id: GO:0006871 +def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732] +synonym: "ornithine cycle" EXACT [] +synonym: "urea biosynthesis" EXACT [] +synonym: "urea biosynthetic process" EXACT [] +xref: Wikipedia:Urea_cycle +is_a: GO:0019627 ! urea metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0000051 +name: obsolete urea cycle intermediate metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. +synonym: "urea cycle intermediate metabolic process" EXACT [] +synonym: "urea cycle intermediate metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000052 +name: citrulline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] +synonym: "citrulline metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0000053 +name: argininosuccinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732] +synonym: "argininosuccinate metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0000054 +name: ribosomal subunit export from nucleus +namespace: biological_process +def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] +subset: goslim_yeast +synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] +synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] +synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] +synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0033750 ! ribosome localization +is_a: GO:0051168 ! nuclear export +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0000055 +name: ribosomal large subunit export from nucleus +namespace: biological_process +alt_id: GO:0000057 +def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] +synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah] +synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah] +synonym: "ribosomal large subunit export from cell nucleus" EXACT [] +synonym: "ribosomal large subunit export out of nucleus" EXACT [] +synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] +synonym: "ribosomal large subunit-nucleus export" EXACT [] +is_a: GO:0000054 ! ribosomal subunit export from nucleus + +[Term] +id: GO:0000056 +name: ribosomal small subunit export from nucleus +namespace: biological_process +alt_id: GO:0000058 +def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] +synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah] +synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah] +synonym: "ribosomal small subunit export from cell nucleus" EXACT [] +synonym: "ribosomal small subunit export out of nucleus" EXACT [] +synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] +synonym: "ribosomal small subunit-nucleus export" EXACT [] +is_a: GO:0000054 ! ribosomal subunit export from nucleus + +[Term] +id: GO:0000059 +name: obsolete protein import into nucleus, docking +namespace: biological_process +def: "OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] +comment: This term was made obsolete because the transient assembly is better captured as a protein-protein association, if at all. +synonym: "protein docking during protein import into nucleus" EXACT [] +synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein docking during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] +synonym: "protein-nucleus import, docking" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000060 +name: obsolete protein import into nucleus, translocation +namespace: biological_process +def: "OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736] +comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. +synonym: "protein import into cell nucleus, translocation" EXACT [] +synonym: "protein translocation during protein import into nucleus" EXACT [] +synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein translocation during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] +synonym: "protein-nucleus import, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000061 +name: obsolete protein import into nucleus, substrate release +namespace: biological_process +def: "OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515] +comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. +synonym: "protein import into cell nucleus, substrate release" EXACT [] +synonym: "protein substrate release during protein import into nucleus" EXACT [] +synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] +synonym: "protein substrate release during protein-nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] +synonym: "protein-nucleus import, substrate release" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000062 +name: fatty-acyl-CoA binding +namespace: molecular_function +def: "Binding to a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, GOC:krc, ISBN:0198506732] +synonym: "fatty-acyl binding" BROAD [] +synonym: "fatty-acyl-coenzyme A binding" EXACT [] +is_a: GO:0120227 ! acyl-CoA binding +is_a: GO:1901567 ! fatty acid derivative binding + +[Term] +id: GO:0000064 +name: L-ornithine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] +synonym: "L-ornithine transporter activity" BROAD [] +xref: Reactome:R-HSA-70634 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)" +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0000067 +name: obsolete DNA replication and chromosome cycle +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. +synonym: "DNA replication and chromosome cycle" EXACT [] +is_obsolete: true +consider: GO:0006260 +consider: GO:0007059 +consider: GO:0051276 + +[Term] +id: GO:0000070 +name: mitotic sister chromatid segregation +namespace: biological_process +alt_id: GO:0016359 +def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] +subset: goslim_pombe +synonym: "mitotic chromosome segregation" EXACT [] +synonym: "mitotic sister-chromatid adhesion release" NARROW [] +is_a: GO:0000819 ! sister chromatid segregation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0000072 +name: obsolete M phase specific microtubule process +namespace: biological_process +def: "OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] +comment: This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary. +synonym: "M phase specific microtubule process" EXACT [] +synonym: "M-phase specific microtubule process" EXACT [] +is_obsolete: true +consider: GO:0007017 + +[Term] +id: GO:0000073 +name: initial mitotic spindle pole body separation +namespace: biological_process +alt_id: GO:0030475 +def: "The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB." [GOC:sgd_curators, GOC:vw] +is_a: GO:0110100 ! spindle pole body separation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0061804 ! mitotic spindle formation (spindle phase one) +relationship: part_of GO:1905047 ! mitotic spindle pole body organization + +[Term] +id: GO:0000075 +name: cell cycle checkpoint signaling +namespace: biological_process +alt_id: GO:0031576 +alt_id: GO:0071779 +alt_id: GO:0072395 +alt_id: GO:0072404 +alt_id: GO:0072407 +def: "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] +comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. +subset: gocheck_do_not_annotate +synonym: "cell cycle checkpoint" EXACT [] +synonym: "G1/S checkpoint" NARROW [] +synonym: "G1/S transition checkpoint" NARROW [] +synonym: "G2/M checkpoint" NARROW [] +synonym: "G2/M transition checkpoint" NARROW [] +synonym: "signal transduction involved in cell cycle checkpoint" EXACT [] +synonym: "signal transduction involved in G2/M transition checkpoint" EXACT [] +xref: Wikipedia:Cell_cycle_checkpoint +is_a: GO:0035556 ! intracellular signal transduction +is_a: GO:1901988 ! negative regulation of cell cycle phase transition + +[Term] +id: GO:0000076 +name: DNA replication checkpoint signaling +namespace: biological_process +alt_id: GO:0072437 +def: "A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] +synonym: "DNA replication checkpoint" EXACT [] +synonym: "signal transduction involved in DNA replication checkpoint" EXACT [] +is_a: GO:0031570 ! DNA integrity checkpoint signaling + +[Term] +id: GO:0000077 +name: DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:0072422 +def: "A signal transduction process that contributes to a DNA damage checkpoint." [GOC:mah] +synonym: "DNA damage checkpoint" EXACT [] +synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] +synonym: "signal transduction involved in DNA damage checkpoint" EXACT [] +xref: Wikipedia:DNA_damage_checkpoint +xref: Wikipedia:Postreplication_checkpoint +is_a: GO:0031570 ! DNA integrity checkpoint signaling +is_a: GO:0042770 ! signal transduction in response to DNA damage + +[Term] +id: GO:0000078 +name: obsolete cytokinesis after mitosis checkpoint +namespace: biological_process +def: "OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle] +comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. +synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw] +synonym: "cell shape checkpoint" EXACT [] +is_obsolete: true +consider: GO:0044878 +consider: GO:0044879 + +[Term] +id: GO:0000079 +name: regulation of cyclin-dependent protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] +synonym: "regulation of CDK activity" EXACT [] +synonym: "regulation of cyclin-dependent protein kinase activity" BROAD [] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity +is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0000080 +name: mitotic G1 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "G1 phase of mitotic cell cycle" EXACT [] +is_a: GO:0051318 ! G1 phase +relationship: part_of GO:0051329 ! mitotic interphase + +[Term] +id: GO:0000082 +name: G1/S transition of mitotic cell cycle +namespace: biological_process +def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] +is_a: GO:0044772 ! mitotic cell cycle phase transition +is_a: GO:0044843 ! cell cycle G1/S phase transition + +[Term] +id: GO:0000083 +name: regulation of transcription involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:0000084 +name: mitotic S phase +namespace: biological_process +def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "S phase of mitotic cell cycle" EXACT [] +synonym: "S-phase of mitotic cell cycle" EXACT [] +is_a: GO:0051320 ! S phase +relationship: part_of GO:0051329 ! mitotic interphase + +[Term] +id: GO:0000085 +name: mitotic G2 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "G2 phase of mitotic cell cycle" EXACT [] +is_a: GO:0051319 ! G2 phase +relationship: part_of GO:0051329 ! mitotic interphase + +[Term] +id: GO:0000086 +name: G2/M transition of mitotic cell cycle +namespace: biological_process +def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] +synonym: "mitotic G2/M transition" EXACT [] +is_a: GO:0044772 ! mitotic cell cycle phase transition +is_a: GO:0044839 ! cell cycle G2/M phase transition + +[Term] +id: GO:0000087 +name: mitotic M phase +namespace: biological_process +def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "M phase of mitotic cell cycle" EXACT [] +synonym: "M-phase of mitotic cell cycle" EXACT [] +is_a: GO:0000279 ! M phase +is_a: GO:0098763 ! mitotic cell cycle phase + +[Term] +id: GO:0000088 +name: mitotic prophase +namespace: biological_process +def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051324 ! prophase +relationship: part_of GO:0000087 ! mitotic M phase + +[Term] +id: GO:0000089 +name: mitotic metaphase +namespace: biological_process +def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051323 ! metaphase +relationship: part_of GO:0000087 ! mitotic M phase + +[Term] +id: GO:0000090 +name: mitotic anaphase +namespace: biological_process +def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051322 ! anaphase +relationship: part_of GO:0000087 ! mitotic M phase + +[Term] +id: GO:0000091 +name: mitotic anaphase A +namespace: biological_process +def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0000090 ! mitotic anaphase + +[Term] +id: GO:0000092 +name: mitotic anaphase B +namespace: biological_process +def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0000090 ! mitotic anaphase + +[Term] +id: GO:0000093 +name: mitotic telophase +namespace: biological_process +def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051326 ! telophase +relationship: part_of GO:0000087 ! mitotic M phase + +[Term] +id: GO:0000094 +name: obsolete septin assembly and septum formation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was not defined and the string name implied two separate processes. +synonym: "septin assembly and septum formation" EXACT [] +is_obsolete: true +consider: GO:0000917 +consider: GO:0000918 +consider: GO:0000921 + +[Term] +id: GO:0000095 +name: S-adenosyl-L-methionine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015177 +def: "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] +synonym: "S-adenosyl methionine permease activity" EXACT [] +synonym: "S-adenosyl methionine transporter activity" EXACT [] +synonym: "S-adenosylmethionine permease activity" EXACT [] +synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT [] +synonym: "S-adenosylmethionine transporter activity" BROAD [] +synonym: "SAM transmembrane transporter activity" EXACT [] +xref: Reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy" +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0000096 +name: sulfur amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] +synonym: "sulfur amino acid metabolism" EXACT [] +synonym: "sulphur amino acid metabolic process" EXACT [] +synonym: "sulphur amino acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0000097 +name: sulfur amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] +synonym: "sulfur amino acid anabolism" EXACT [] +synonym: "sulfur amino acid biosynthesis" EXACT [] +synonym: "sulfur amino acid formation" EXACT [] +synonym: "sulfur amino acid synthesis" EXACT [] +synonym: "sulphur amino acid biosynthesis" EXACT [] +synonym: "sulphur amino acid biosynthetic process" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0000098 +name: sulfur amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] +synonym: "sulfur amino acid breakdown" EXACT [] +synonym: "sulfur amino acid catabolism" EXACT [] +synonym: "sulfur amino acid degradation" EXACT [] +synonym: "sulphur amino acid catabolic process" EXACT [] +synonym: "sulphur amino acid catabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0000099 +name: sulfur amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "sulfur amino acid transporter activity" BROAD [] +synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] +synonym: "sulphur amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0000100 +name: S-methylmethionine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015178 +def: "Enables the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] +synonym: "S-methylmethionine permease activity" EXACT [] +synonym: "S-methylmethionine transporter activity" BROAD [] +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0000101 +name: sulfur amino acid transport +namespace: biological_process +def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "sulphur amino acid transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0000102 +name: L-methionine secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "L-methionine porter activity" RELATED [] +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0015191 ! L-methionine transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity + +[Term] +id: GO:0000103 +name: sulfate assimilation +namespace: biological_process +alt_id: GO:0019378 +def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] +synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] +synonym: "sulphate assimilation" EXACT [] +synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0000104 +name: succinate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0019739 +def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [GOC:kd] +synonym: "fumarate dehydrogenase activity" EXACT [] +synonym: "fumarate reductase activity" EXACT [] +synonym: "fumaric hydrogenase activity" RELATED [EC:1.3.99.1] +synonym: "succinate oxidoreductase activity" EXACT [] +synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [] +synonym: "succinate:acceptor oxidoreductase activity" EXACT [] +synonym: "succinic acid dehydrogenase activity" EXACT [] +synonym: "succinic dehydrogenase activity" BROAD [] +synonym: "succinodehydrogenase activity" EXACT [] +synonym: "succinyl dehydrogenase activity" EXACT [] +xref: MetaCyc:SUCC-FUM-OXRED-RXN +xref: RHEA:16357 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0000105 +name: histidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +synonym: "histidine anabolism" EXACT [] +synonym: "histidine biosynthesis" EXACT [] +synonym: "histidine formation" EXACT [] +synonym: "histidine synthesis" EXACT [] +xref: MetaCyc:HISTSYN-PWY +is_a: GO:0006547 ! histidine metabolic process +is_a: GO:0008652 ! cellular amino acid biosynthetic process + +[Term] +id: GO:0000107 +name: imidazoleglycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [RHEA:24793] +synonym: "glutamine amidotransferase:cyclase activity" BROAD [] +synonym: "imidazole glycerol phosphate synthase activity" EXACT [] +synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] +synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] +xref: MetaCyc:GLUTAMIDOTRANS-RXN +xref: RHEA:24793 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0000108 +name: obsolete repairosome +namespace: cellular_component +def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] +comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators. +synonym: "repairosome" EXACT [] +is_obsolete: true +replaced_by: GO:0000109 + +[Term] +id: GO:0000109 +name: nucleotide-excision repair complex +namespace: cellular_component +def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] +comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. +subset: goslim_pir +synonym: "UvrB-UvrC complex" NARROW [PMID:12145219] +synonym: "UvrBC complex" NARROW [GOC:bhm, PMID:12145219] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990391 ! DNA repair complex + +[Term] +id: GO:0000110 +name: nucleotide-excision repair factor 1 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF1 complex" EXACT [] +synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000111 +name: nucleotide-excision repair factor 2 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF2 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000112 +name: nucleotide-excision repair factor 3 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF3 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000113 +name: nucleotide-excision repair factor 4 complex +namespace: cellular_component +def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "NEF4 complex" EXACT [] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0000114 +name: obsolete regulation of transcription involved in G1 phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. +synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] +synonym: "regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0000083 +consider: GO:0006357 + +[Term] +id: GO:0000115 +name: obsolete regulation of transcription involved in S phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. +synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] +synonym: "regulation of transcription involved in S phase of mitotic cell cycle" EXACT [] +synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] +synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] +synonym: "S-specific transcription in mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0000083 +consider: GO:0006357 + +[Term] +id: GO:0000116 +name: obsolete regulation of transcription involved in G2-phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. +synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] +synonym: "regulation of transcription involved in G2-phase of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0000117 +consider: GO:0006357 + +[Term] +id: GO:0000117 +name: regulation of transcription involved in G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle] +synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] +synonym: "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle" RELATED [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0000118 +name: histone deacetylase complex +namespace: cellular_component +def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] +comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. +synonym: "HDAC complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0000120 +name: RNA polymerase I transcription regulator complex +namespace: cellular_component +def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I." [GOC:mah] +synonym: "RNA polymerase I transcription factor complex" NARROW [] +is_a: GO:0005667 ! transcription regulator complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0000121 +name: glycerol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] +synonym: "alpha-glycerol phosphatase activity" RELATED [EC:3.1.3.21] +synonym: "alpha-glycerophosphatase activity" RELATED [EC:3.1.3.21] +synonym: "glycerol 3-phosphatase activity" RELATED [EC:3.1.3.21] +synonym: "glycerol 3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.21] +synonym: "glycerol-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.21] +synonym: "glycerol-3-phosphate phosphatase activity" RELATED [EC:3.1.3.21] +xref: EC:3.1.3.21 +xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN +xref: RHEA:11476 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0000122 +name: negative regulation of transcription by RNA polymerase II +namespace: biological_process +alt_id: GO:0010553 +alt_id: GO:0045816 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] +synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] +synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] +synonym: "negative regulation of transcription from Pol II promoter" EXACT [] +synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0000123 +name: histone acetyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] +comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. +synonym: "histone acetylase complex" EXACT [] +is_a: GO:0031248 ! protein acetyltransferase complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0000124 +name: SAGA complex +namespace: cellular_component +alt_id: GO:0000125 +alt_id: GO:0030914 +def: "A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695)." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651, PMID:33004486] +synonym: "PCAF complex" NARROW [] +synonym: "PCAF histone acetylase-associated complex" NARROW [] +synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] +synonym: "SPT3-TAF9-GCN5 acetylase complex" RELATED [GOC:rl, PMID:18838386] +synonym: "SPT3-TAF9-PCAF acetylase complex" NARROW [PMID:18838386] +synonym: "STAGA coactivator complex" RELATED [] +synonym: "STAGA complex" RELATED [PMID:32616828, PMID:33004486, PMID:34112237] +is_a: GO:0070461 ! SAGA-type complex +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:0000126 +name: transcription factor TFIIIB complex +namespace: cellular_component +def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex + +[Term] +id: GO:0000127 +name: transcription factor TFIIIC complex +namespace: cellular_component +def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex + +[Term] +id: GO:0000128 +name: flocculation +namespace: biological_process +alt_id: GO:0000501 +alt_id: GO:0032128 +alt_id: GO:0036281 +alt_id: GO:0036282 +alt_id: GO:0043689 +alt_id: GO:0043690 +def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:11472912, PMID:21114594, PMID:8740415] +comment: The word floc derives from the Latin word floccus, which means a tuft of wool. +subset: goslim_pir +synonym: "cell-cell adhesion involved in flocculation" EXACT [] +synonym: "cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction" NARROW [] +synonym: "co-flocculation" NARROW [PMID:10689163] +synonym: "coflocculation" NARROW [] +synonym: "coflocculation via lectin-mannose interaction" NARROW [PMID:11693916] +synonym: "coflocculation via protein-carbohydrate interaction" NARROW [] +synonym: "flocculation via cell wall protein-carbohydrate interaction" RELATED [] +synonym: "flocculation via extracellular polymer" RELATED [] +xref: Wikipedia:Flocculation +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms +is_a: GO:0098610 ! adhesion between unicellular organisms + +[Term] +id: GO:0000131 +name: incipient cellular bud site +namespace: cellular_component +def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0000132 +name: establishment of mitotic spindle orientation +namespace: biological_process +alt_id: GO:0030607 +alt_id: GO:0030609 +def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] +synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] +synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "mitotic spindle orientation" EXACT [] +synonym: "orienting of mitotic spindle" EXACT [] +is_a: GO:0040001 ! establishment of mitotic spindle localization +is_a: GO:0051294 ! establishment of spindle orientation + +[Term] +id: GO:0000133 +name: polarisome +namespace: cellular_component +def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005938 ! cell cortex +relationship: part_of GO:0030427 ! site of polarized growth + +[Term] +id: GO:0000136 +name: mannan polymerase complex +namespace: cellular_component +def: "A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825] +synonym: "alpha-1,6-mannosyltransferase complex" EXACT [] +is_a: GO:0031501 ! mannosyltransferase complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0000137 ! Golgi cis cisterna +relationship: part_of GO:0030173 ! integral component of Golgi membrane + +[Term] +id: GO:0000137 +name: Golgi cis cisterna +namespace: cellular_component +def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0000138 +name: Golgi trans cisterna +namespace: cellular_component +def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] +synonym: "late Golgi" RELATED [GOC:mah] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0000139 +name: Golgi membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0000140 +name: acylglycerone-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101] +synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] +synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.101] +synonym: "acyldihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101] +synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.101] +synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101] +synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" RELATED [EC:1.1.1.101] +xref: EC:1.1.1.101 +xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN +xref: Reactome:R-HSA-75883 "DHRS7B reduces GO3P to HXDG3P" +xref: RHEA:17341 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000142 +name: cellular bud neck contractile ring +namespace: cellular_component +def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] +synonym: "neck ring" EXACT [] +is_a: GO:0110085 ! mitotic actomyosin contractile ring +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0000144 +name: cellular bud neck septin ring +namespace: cellular_component +def: "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0005940 ! septin ring +is_a: GO:0032161 ! cleavage apparatus septin structure + +[Term] +id: GO:0000145 +name: exocyst +namespace: cellular_component +def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152] +synonym: "exocyst complex" EXACT [] +synonym: "Sec6/8 complex" EXACT [] +xref: Wikipedia:Exocyst +is_a: GO:0099023 ! vesicle tethering complex +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0000146 +name: microfilament motor activity +namespace: molecular_function +alt_id: GO:0030898 +def: "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis." [PMID:29716949] +synonym: "actin filament motor activity" EXACT [GOC:dph] +synonym: "actin-activated ATPase activity" EXACT [] +synonym: "actin-dependent ATPase activity" EXACT [] +synonym: "actin-filament motor activity" EXACT [] +synonym: "muscle motor activity" NARROW [] +synonym: "myosin ATPase activity" RELATED [] +xref: EC:5.6.1.8 +xref: Reactome:R-HSA-2316352 "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane" +xref: Reactome:R-HSA-432237 "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane" +xref: Reactome:R-HSA-9023171 "Insulin secretory granule translocates across the cortical actin network" +is_a: GO:0003774 ! cytoskeletal motor activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0000147 +name: actin cortical patch assembly +namespace: biological_process +def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0030866 ! cortical actin cytoskeleton organization +is_a: GO:0044396 ! actin cortical patch organization + +[Term] +id: GO:0000148 +name: 1,3-beta-D-glucan synthase complex +namespace: cellular_component +def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34] +synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb] +synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0000149 +name: SNARE binding +namespace: molecular_function +def: "Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] +subset: goslim_chembl +synonym: "SNAP receptor binding" EXACT [] +xref: Reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming" +xref: Reactome:R-HSA-210430 "Release of L-Glutamate at the synapse" +xref: Reactome:R-HSA-265166 "Exocytosis of Insulin" +xref: Reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming" +xref: Reactome:R-HSA-372529 "Release of acetylcholine at the synapse" +xref: Reactome:R-HSA-374899 "Release of noradrenaline at the synapse" +xref: Reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming" +xref: Reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport" +xref: Reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport" +xref: Reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport" +xref: Reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming" +xref: Reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle" +xref: Reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle" +xref: Reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming" +xref: Reactome:R-HSA-888589 "Release of GABA at the synapse" +xref: Reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane" +xref: Reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming" +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0000150 +name: DNA strand exchange activity +namespace: molecular_function +def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] +comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. +subset: goslim_metagenomics +synonym: "RecA-family recombinase activity" RELATED [] +synonym: "recombinase activity" EXACT [] +synonym: "strand exchange activity" RELATED [] +synonym: "strand transferase" NARROW [] +xref: Reactome:R-HSA-912458 "Formation of meiotic heteroduplex" +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0000151 +name: ubiquitin ligase complex +namespace: cellular_component +def: "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0000152 +name: nuclear ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0000153 +name: cytoplasmic ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] +is_a: GO:0000151 ! ubiquitin ligase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000154 +name: rRNA modification +namespace: biological_process +alt_id: GO:0016548 +def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +synonym: "rRNA editing" NARROW [GOC:hjd] +is_a: GO:0006364 ! rRNA processing +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0000155 +name: phosphorelay sensor kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] +synonym: "two-component sensor activity" NARROW [] +synonym: "two-component sensor molecule" NARROW [] +synonym: "two-component system sensor activity" NARROW [] +xref: EC:2.7.3.- +is_a: GO:0004673 ! protein histidine kinase activity +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0000156 +name: phosphorelay response regulator activity +namespace: molecular_function +def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] +synonym: "two-component response regulator activity" NARROW [] +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0000159 +name: protein phosphatase type 2A complex +namespace: cellular_component +def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] +synonym: "PP2A complex" EXACT [] +synonym: "PP2A-pi" NARROW [] +synonym: "PP2a-protector" NARROW [] +synonym: "protein phosphatase 2 complex" RELATED [GOC:dph, GOC:rl] +is_a: GO:0005963 ! magnesium-dependent protein serine/threonine phosphatase complex + +[Term] +id: GO:0000160 +name: phosphorelay signal transduction system +namespace: biological_process +def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] +subset: goslim_metagenomics +synonym: "histidyl-aspartyl phosphorelay" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0000161 +name: osmosensory signaling MAPK cascade +namespace: biological_process +alt_id: GO:0000167 +alt_id: GO:0000168 +alt_id: GO:0000169 +alt_id: GO:0000173 +alt_id: GO:0007233 +def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K." [PMID:17604854, PMID:9561267] +synonym: "activation of MAPK activity involved in osmosensory signaling pathway" NARROW [] +synonym: "activation of MAPKK activity during osmolarity sensing" NARROW [] +synonym: "activation of MAPKK activity involved in osmosensory signaling pathway" NARROW [] +synonym: "activation of MAPKKK activity during osmolarity sensing" NARROW [] +synonym: "activation of MAPKKK activity involved in osmosensory signaling pathway" NARROW [] +synonym: "activation of Pbs2 kinase" NARROW [] +synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736] +synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736] +synonym: "Hog1/Sty1 stress-activated MAPK cascade" NARROW [] +synonym: "inactivation of MAPK activity involved in osmosensory signaling pathway" NARROW [] +synonym: "MAPK cascade involved in osmosensory signaling pathway" EXACT [] +synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] +synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling] +synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "osmolarity sensing, activation of MAP kinase kinase activity" NARROW [] +synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" NARROW [] +synonym: "osmolarity sensing, activation of MAPK activity" NARROW [] +synonym: "osmolarity sensing, activation of MAPKK activity" NARROW [] +synonym: "osmolarity sensing, activation of MAPKKK activity" NARROW [] +synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] +synonym: "termination of MAPK activity during osmolarity sensing" NARROW [] +is_a: GO:0007231 ! osmosensory signaling pathway +is_a: GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0000162 +name: tryptophan biosynthetic process +namespace: biological_process +alt_id: GO:0009096 +def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY] +synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] +synonym: "tryptophan anabolism" EXACT [] +synonym: "tryptophan biosynthesis" EXACT [] +synonym: "tryptophan formation" EXACT [] +synonym: "tryptophan synthesis" EXACT [] +xref: MetaCyc:TRPSYN-PWY +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process +is_a: GO:0046219 ! indolalkylamine biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0000164 +name: protein phosphatase type 1 complex +namespace: cellular_component +def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000165 +name: MAPK cascade +namespace: biological_process +alt_id: GO:0007255 +def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] +comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. +synonym: "ERK/MAPK cascade" NARROW [] +synonym: "MAP kinase cascade" EXACT [] +synonym: "MAP kinase kinase kinase cascade" EXACT [] +synonym: "MAPK signal transduction" EXACT [GOC:signaling] +synonym: "MAPK signaling" RELATED [] +synonym: "MAPK signalling" RELATED [] +synonym: "MAPKKK cascade" EXACT [] +synonym: "MAPKKK cascade during sporulation" NARROW [] +synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] +xref: Wikipedia:MAPK_cascade +xref: Wikipedia:Mitogen-activated_protein_kinase +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0000166 +name: nucleotide binding +namespace: molecular_function +def: "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +is_a: GO:0036094 ! small molecule binding +is_a: GO:1901265 ! nucleoside phosphate binding + +[Term] +id: GO:0000170 +name: sphingosine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] +xref: Reactome:R-HSA-428260 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0000171 +name: ribonuclease MRP activity +namespace: molecular_function +def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] +synonym: "RNase MRP" EXACT [] +xref: Wikipedia:RNase_MRP +is_a: GO:0004521 ! endoribonuclease activity + +[Term] +id: GO:0000172 +name: ribonuclease MRP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] +synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] +synonym: "RNase MRP complex" EXACT [] +is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:0000174 +name: obsolete inactivation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "inactivation of MAPK (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0000175 +name: 3'-5'-exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +synonym: "3'-5' exoribonuclease activity" EXACT [] +xref: EC:3.1.13.- +xref: Reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion" +xref: Reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA" +xref: Reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA" +xref: Reactome:R-HSA-9682603 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA" +xref: Reactome:R-HSA-9694632 "nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA" +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0000176 +name: nuclear exosome (RNase complex) +namespace: cellular_component +def: "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] +synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] +synonym: "nuclear exosome (ribonuclease complex)" EXACT [] +synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:0000178 ! exosome (RNase complex) +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0000177 +name: cytoplasmic exosome (RNase complex) +namespace: cellular_component +def: "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] +synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] +synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] +synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:0000178 ! exosome (RNase complex) +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000178 +name: exosome (RNase complex) +namespace: cellular_component +def: "A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] +comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. +subset: goslim_pir +synonym: "exosome (ribonucleasease complex)" EXACT [] +synonym: "exosome multienzyme ribonuclease complex" EXACT [] +is_a: GO:1905354 ! exoribonuclease complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0000179 +name: rRNA (adenine-N6,N6-)-dimethyltransferase activity +namespace: molecular_function +alt_id: GO:0043790 +def: "Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] +synonym: "18S rRNA dimethylase activity" EXACT [] +synonym: "dimethyladenosine transferase activity" EXACT [] +synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [] +xref: Reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851" +xref: Reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0000180 +name: obsolete cytosolic large ribosomal subunit +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because more specific children exist. +synonym: "cytosolic large ribosomal subunit" EXACT [] +is_obsolete: true +consider: GO:0022625 + +[Term] +id: GO:0000181 +name: obsolete cytosolic small ribosomal subunit +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because more specific children exist. +synonym: "cytosolic small ribosomal subunit" EXACT [] +is_obsolete: true +consider: GO:0022627 + +[Term] +id: GO:0000182 +name: rDNA binding +namespace: molecular_function +def: "Binding to a DNA sequence encoding a ribosomal RNA." [GOC:mah] +synonym: "ribosomal DNA binding" EXACT [] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0000183 +name: rDNA heterochromatin assembly +namespace: biological_process +def: "The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA." [PMID:10219245] +synonym: "chromatin silencing at rDNA" RELATED [] +synonym: "chromatin silencing at ribosomal DNA" BROAD [] +synonym: "heterochromatic silencing at rDNA" BROAD [] +synonym: "rDNA chromatin silencing" BROAD [GOC:mah] +is_a: GO:0140718 ! facultative heterochromatin assembly +relationship: part_of GO:1990700 ! nucleolar chromatin organization + +[Term] +id: GO:0000184 +name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +namespace: biological_process +def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] +synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] +synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] +synonym: "mRNA catabolism, nonsense-mediated" EXACT [] +synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] +synonym: "nonsense-mediated mRNA decay" EXACT [] +synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] +xref: Wikipedia:Nonsense-mediated_decay +xref: Wikipedia:Nonsense-mediated_mRNA_decay +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000185 +name: obsolete activation of MAPKKK activity +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of MAP kinase kinase kinase" EXACT [] +synonym: "activation of MAP3K activity" EXACT [GOC:bf] +synonym: "activation of MAPKKK activity during sporulation" NARROW [] +synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] +synonym: "positive regulation of MAPKKK activity" BROAD [] +is_obsolete: true +consider: GO:0000165 +consider: GO:0043539 + +[Term] +id: GO:0000186 +name: obsolete activation of MAPKK activity +namespace: biological_process +def: "OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of MAP kinase kinase activity" EXACT [] +synonym: "activation of MAP/ERK kinase kinase" EXACT [] +synonym: "activation of MAP2K activity" EXACT [GOC:bf] +synonym: "activation of MAPKK activity during sporulation" NARROW [] +synonym: "positive regulation of MAPKK activity" BROAD [] +is_obsolete: true +consider: GO:0000165 +consider: GO:0043539 + +[Term] +id: GO:0000187 +name: obsolete activation of MAPK activity +namespace: biological_process +def: "OBSOLETE. The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of MAP kinase" EXACT [] +synonym: "activation of MAPK activity during sporulation" NARROW [] +synonym: "MAPK activation" EXACT [] +is_obsolete: true +consider: GO:0000165 +consider: GO:0043539 + +[Term] +id: GO:0000188 +name: obsolete inactivation of MAPK activity +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] +comment: This term was obsoleted because it represents a molecular function. +synonym: "inactivation of MAPK during sporulation" NARROW [] +synonym: "termination of MAPK activity" EXACT [] +is_obsolete: true +consider: GO:0000165 +consider: GO:0043539 + +[Term] +id: GO:0000189 +name: obsolete MAPK import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "nuclear translocation of MAPK" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0000190 +name: obsolete MAPKKK cascade (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "MAPKKK cascade (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000191 +name: obsolete activation of MAPKKK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKKK (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000192 +name: obsolete activation of MAPKK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKK (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000193 +name: obsolete activation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPK (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000194 +name: obsolete inactivation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "inactivation of MAPK (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000195 +name: obsolete nuclear translocation of MAPK (pseudohyphal growth) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "nuclear translocation of MAPK (pseudohyphal growth)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000196 +name: cell wall integrity MAPK cascade +namespace: biological_process +def: "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:17604854, PMID:9561267] +synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882] +synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] +synonym: "MAPK cascade involved in cell wall biogenesis" NARROW [GOC:vw] +synonym: "MAPK cascade involved in cell wall organization or biogenesis" EXACT [] +synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] +synonym: "Mpk1 cascade" NARROW [PMID:10523653] +synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302] +synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882] +synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094] +synonym: "Slt2 cascade" NARROW [PMID:10523653] +is_a: GO:0051403 ! stress-activated MAPK cascade +relationship: part_of GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0000197 +name: obsolete activation of MAPKKK activity involved in cell wall organization or biogenesis +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] +synonym: "activation of MAPKKK activity involved in cell wall biogenesis" RELATED [] +synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] +synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] +synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] +is_obsolete: true +consider: GO:0000165 +consider: GO:0043539 + +[Term] +id: GO:0000198 +name: obsolete activation of MAPKK activity involved in cell wall organization or biogenesis +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] +synonym: "activation of MAPKK activity involved in cell wall biogenesis" RELATED [] +synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] +synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] +synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000199 +name: obsolete activation of MAPK activity involved in cell wall organization or biogenesis +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAPK activity involved in cell wall biogenesis" NARROW [] +synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] +synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000200 +name: obsolete inactivation of MAPK activity involved in cell wall organization or biogenesis +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis." [PMID:9561267] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] +synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] +synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] +synonym: "inactivation of MAPK activity involved in cell wall organization or biogenesis" RELATED [] +synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000201 +name: obsolete MAPK import into nucleus involved in cell wall organization or biogenesis +namespace: biological_process +def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis." [PMID:9561267] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah] +synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah] +synonym: "MAPK import into nucleus involved in cell wall biogenesis" NARROW [GOC:vw] +synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah] +synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah] +synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0000202 +name: obsolete MAPKKK cascade during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000203 +name: obsolete activation of MAPKKK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000204 +name: obsolete activation of MAPKK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000205 +name: obsolete activation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000206 +name: obsolete inactivation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000207 +name: obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "nuclear translocation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000208 +name: obsolete MAPK import into nucleus involved in osmosensory signaling pathway +namespace: biological_process +def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah] +synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] +synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah] +synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah] +synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah] +synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0000209 +name: protein polyubiquitination +namespace: biological_process +def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] +synonym: "polyubiquitin" RELATED [] +synonym: "protein polyubiquitinylation" EXACT [] +synonym: "protein polyubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0000210 +name: NAD+ diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] +synonym: "NAD diphosphatase activity" EXACT [] +synonym: "NAD pyrophosphatase activity" EXACT [] +synonym: "NAD(+) pyrophosphatase activity" RELATED [EC:3.6.1.22] +synonym: "NAD+ phosphohydrolase activity" RELATED [EC:3.6.1.22] +synonym: "NAD+ pyrophosphatase activity" RELATED [EC:3.6.1.22] +synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] +synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] +synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.22] +xref: EC:3.6.1.22 +xref: MetaCyc:NADPYROPHOSPHAT-RXN +xref: RHEA:11800 +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0000211 +name: obsolete protein degradation tagging activity +namespace: molecular_function +def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] +comment: This term was made obsolete because it represents a biological process and a molecular function. +synonym: "protein degradation tagging activity" EXACT [] +is_obsolete: true +consider: GO:0005515 +consider: GO:0019941 + +[Term] +id: GO:0000212 +name: meiotic spindle organization +namespace: biological_process +alt_id: GO:0043147 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah] +synonym: "meiotic spindle organisation" EXACT [] +synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] +synonym: "meiotic spindle stabilization" RELATED [] +synonym: "spindle organization during meiosis" EXACT [GOC:mah] +is_a: GO:0007051 ! spindle organization +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0000213 +name: tRNA-intron endonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] +synonym: "splicing endonuclease activity" RELATED [EC:3.1.27.9] +synonym: "transfer ribonucleate intron endoribonuclease activity" RELATED [EC:3.1.27.9] +synonym: "transfer splicing endonuclease activity" RELATED [EC:3.1.27.9] +synonym: "tRNA splicing endonuclease activity" RELATED [EC:3.1.27.9] +synonym: "tRNA-intron endoribonuclease activity" EXACT [] +synonym: "tRNA-splicing endonuclease activity" RELATED [EC:3.1.27.9] +synonym: "tRNATRPintron endonuclease activity" RELATED [EC:3.1.27.9] +xref: EC:3.1.27.9 +xref: MetaCyc:3.1.27.9-RXN +is_a: GO:0004549 ! tRNA-specific ribonuclease activity +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0000214 +name: tRNA-intron endonuclease complex +namespace: cellular_component +def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [PMID:22391451] +synonym: "SEN complex" EXACT [GOC:se, PMID:22391451] +synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:0000215 +name: tRNA 2'-phosphotransferase activity +namespace: molecular_function +alt_id: GO:0008665 +def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] +subset: goslim_chembl +synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160] +synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" RELATED [EC:2.7.1.160] +synonym: "2'-phosphotransferase activity" BROAD [] +synonym: "Tpt1" RELATED [EC:2.7.1.160] +synonym: "Tpt1p" RELATED [EC:2.7.1.160] +synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] +xref: EC:2.7.1.160 +xref: MetaCyc:2.7.1.160-RXN +xref: RHEA:23324 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0000216 +name: obsolete M/G1 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "M/G1 transition of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000217 +name: DNA secondary structure binding +namespace: molecular_function +def: "Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction." [GOC:krc] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0000219 +name: obsolete vacuolar hydrogen-transporting ATPase +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "V-ATPase" EXACT [] +synonym: "vacuolar hydrogen-transporting ATPase" EXACT [] +is_obsolete: true +consider: GO:0016469 + +[Term] +id: GO:0000220 +name: vacuolar proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] +comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. +synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain +relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex + +[Term] +id: GO:0000221 +name: vacuolar proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] +comment: Note that this domain generally consists of eight subunits. +synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain +relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex + +[Term] +id: GO:0000222 +name: plasma membrane proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex + +[Term] +id: GO:0000223 +name: plasma membrane proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex + +[Term] +id: GO:0000224 +name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] +synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] +synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] +synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] +synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] +synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.52] +synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] +synonym: "peptide:N-glycanase" RELATED [] +synonym: "PNGase" EXACT [] +synonym: "PNGase A" RELATED [EC:3.5.1.52] +synonym: "PNGase F" RELATED [EC:3.5.1.52] +xref: EC:3.5.1.52 +xref: MetaCyc:3.5.1.52-RXN +xref: Reactome:R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins" +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0000225 +name: N-acetylglucosaminylphosphatidylinositol deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89] +comment: Note that this function was formerly EC:3.1.1.69. +synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" RELATED [EC:3.5.1.89] +synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" RELATED [EC:3.5.1.89] +synonym: "GlcNAc-PI de-N-acetylase activity" RELATED [EC:3.5.1.89] +synonym: "GlcNAc-PI deacetylase activity" RELATED [EC:3.5.1.89] +synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" RELATED [EC:3.5.1.89] +synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" RELATED [EC:3.5.1.89] +xref: EC:3.5.1.89 +xref: MetaCyc:3.1.1.69-RXN +xref: Reactome:R-HSA-162857 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate" +xref: RHEA:11660 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0000226 +name: microtubule cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] +subset: goslim_pombe +synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] +synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] +synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0007017 ! microtubule-based process + +[Term] +id: GO:0000227 +name: oxaloacetate secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "oxaloacetate carrier activity" RELATED [] +is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0000228 +name: nuclear chromosome +namespace: cellular_component +def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] +subset: goslim_chembl +subset: goslim_generic +synonym: "nuclear interphase chromosome" NARROW [] +is_a: GO:0005694 ! chromosome +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0000229 +name: obsolete cytoplasmic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cytoplasm." [GOC:mah] +comment: This term was obsoleted because it is an unnecessary grouping class. +synonym: "cytoplasmic interphase chromosome" NARROW [] +is_obsolete: true +replaced_by: GO:0005694 + +[Term] +id: GO:0000230 +name: obsolete nuclear mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "nuclear mitotic chromosome" EXACT [] +is_obsolete: true +consider: GO:0000794 + +[Term] +id: GO:0000231 +name: obsolete cytoplasmic mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "cytoplasmic mitotic chromosome" EXACT [] +is_obsolete: true +consider: GO:0000793 + +[Term] +id: GO:0000232 +name: obsolete nuclear interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "nuclear interphase chromosome" EXACT [] +is_obsolete: true +consider: GO:0000228 + +[Term] +id: GO:0000233 +name: obsolete cytoplasmic interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "cytoplasmic interphase chromosome" EXACT [] +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0000234 +name: phosphoethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] +synonym: "phosphoethanolamine methyltransferase activity" RELATED [EC:2.1.1.103] +synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" RELATED [EC:2.1.1.103] +xref: EC:2.1.1.103 +xref: KEGG_REACTION:R02037 +xref: MetaCyc:2.1.1.103-RXN +xref: RHEA:20365 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0000235 +name: astral microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] +is_a: GO:0005876 ! spindle microtubule +is_a: GO:0005881 ! cytoplasmic microtubule +relationship: part_of GO:0005818 ! aster + +[Term] +id: GO:0000236 +name: mitotic prometaphase +namespace: biological_process +def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0098763 ! mitotic cell cycle phase + +[Term] +id: GO:0000237 +name: leptotene +namespace: biological_process +def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Leptotene +xref: Wikipedia:Meiosis#Leptotene +is_a: GO:0098764 ! meiosis I cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000238 +name: zygotene +namespace: biological_process +def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Meiosis#Zygotene +xref: Wikipedia:Zygotene +is_a: GO:0098764 ! meiosis I cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000239 +name: pachytene +namespace: biological_process +def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Meiosis#Pachytene +xref: Wikipedia:Pachytene +is_a: GO:0098764 ! meiosis I cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000240 +name: diplotene +namespace: biological_process +def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Diplotene +xref: Wikipedia:Meiosis#Diplotene +is_a: GO:0098764 ! meiosis I cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000241 +name: diakinesis +namespace: biological_process +def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Diakinesis +xref: Wikipedia:Meiosis#Diakinesis +is_a: GO:0098764 ! meiosis I cell cycle phase +relationship: part_of GO:0007128 ! meiotic prophase I + +[Term] +id: GO:0000242 +name: pericentriolar material +namespace: cellular_component +def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0000243 +name: commitment complex +namespace: cellular_component +def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] +synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] +synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex + +[Term] +id: GO:0000244 +name: spliceosomal tri-snRNP complex assembly +namespace: biological_process +alt_id: GO:0000351 +alt_id: GO:0000355 +def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] +synonym: "assembly of spliceosomal tri-snRNP" EXACT [] +synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] +synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] +synonym: "snRNP recycling" BROAD [] +synonym: "spliceosomal tri-snRNP assembly" EXACT [] +synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] +synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] +is_a: GO:0000387 ! spliceosomal snRNP assembly + +[Term] +id: GO:0000245 +name: spliceosomal complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] +synonym: "spliceosome assembly" BROAD [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000246 +name: delta24(24-1) sterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18501] +synonym: "C-24(28) sterol reductase activity" RELATED [EC:1.3.1.71] +synonym: "D24(24-1)-sterol reductase activity" EXACT [] +synonym: "delta24(241)-sterol reductase activity" RELATED [EC:1.3.1.71] +synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" RELATED [EC:1.3.1.71] +synonym: "sterol Delta(24(28))-methylene reductase activity" RELATED [EC:1.3.1.71] +synonym: "sterol Delta(24(28))-reductase activity" RELATED [EC:1.3.1.71] +synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] +synonym: "sterol delta-24(28) reductase activity" EXACT [] +synonym: "sterol delta24(28)-methylene reductase activity" RELATED [EC:1.3.1.71] +synonym: "sterol delta24(28)-reductase activity" RELATED [EC:1.3.1.71] +xref: EC:1.3.1.71 +xref: KEGG_REACTION:R05641 +xref: MetaCyc:1.3.1.71-RXN +xref: RHEA:18501 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000247 +name: C-8 sterol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] +synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0000248 +name: C-5 sterol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] +synonym: "sterol-C5-desaturase activity" EXACT [] +xref: Reactome:R-HSA-195664 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol" +xref: Reactome:R-HSA-6807053 "SC5D desaturates LTHSOL to 7-dehydroCHOL" +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +is_a: GO:0070704 ! sterol desaturase activity + +[Term] +id: GO:0000249 +name: C-22 sterol desaturase activity +namespace: molecular_function +def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +is_a: GO:0070704 ! sterol desaturase activity + +[Term] +id: GO:0000250 +name: lanosterol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14621] +synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" RELATED [EC:5.4.99.7] +synonym: "2,3-epoxysqualene lanosterol cyclase activity" RELATED [EC:5.4.99.7] +synonym: "2,3-epoxysqualene--lanosterol cyclase activity" RELATED [EC:5.4.99.7] +synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] +synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] +synonym: "2,3-oxidosqualene-lanosterol cyclase activity" RELATED [EC:5.4.99.7] +synonym: "lanosterol 2,3-oxidosqualene cyclase activity" RELATED [EC:5.4.99.7] +synonym: "OSC" EXACT [] +synonym: "oxidosqualene--lanosterol cyclase activity" RELATED [EC:5.4.99.7] +synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] +synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] +synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" RELATED [EC:5.4.99.7] +synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] +synonym: "squalene-2,3-oxide-lanosterol cyclase activity" RELATED [EC:5.4.99.7] +xref: EC:5.4.99.7 +xref: KEGG_REACTION:R03199 +xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN +xref: Reactome:R-HSA-191366 "Squalene 2,3-epoxide cyclizes, forming lanosterol" +xref: RHEA:14621 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0000252 +name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] +synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] +synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] +synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] +synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] +synonym: "C-3 sterol dehydrogenase activity" RELATED [] +synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] +synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] +synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] +xref: EC:1.1.1.170 +xref: Reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one" +xref: Reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000253 +name: 3-keto sterol reductase activity +namespace: molecular_function +alt_id: GO:0050576 +def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "3-keto-steroid reductase activity" EXACT [] +synonym: "3-KSR activity" RELATED [EC:1.1.1.270] +synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] +xref: EC:1.1.1.270 +xref: MetaCyc:1.1.1.270-RXN +xref: MetaCyc:RXN3O-4110 +xref: MetaCyc:RXN66-19 +xref: MetaCyc:RXN66-24 +xref: MetaCyc:RXN66-314 +xref: MetaCyc:RXN66-319 +xref: Reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)" +xref: Reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol" +xref: RHEA:18409 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000254 +name: C-4 methylsterol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.18.9, PMID:9811880] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.18.9] +synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.18.9] +synonym: "4-methylsterol oxidase activity" EXACT [] +synonym: "methylsterol hydroxylase activity" RELATED [] +synonym: "methylsterol monooxygenase activity" RELATED [] +xref: EC:1.14.18.9 +xref: MetaCyc:1.14.13.72-RXN +xref: Reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol" +xref: Reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol" +xref: RHEA:55220 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0000255 +name: allantoin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] +synonym: "allantoin metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0000256 +name: allantoin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] +synonym: "allantoin breakdown" EXACT [] +synonym: "allantoin catabolism" EXACT [] +synonym: "allantoin degradation" EXACT [] +is_a: GO:0000255 ! allantoin metabolic process +is_a: GO:0043605 ! cellular amide catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0000257 +name: nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] +synonym: "acetonitrilase activity" RELATED [EC:3.5.5.1] +synonym: "benzonitrilase activity" RELATED [EC:3.5.5.1] +synonym: "nitrile aminohydrolase activity" RELATED [EC:3.5.5.1] +xref: EC:3.5.5.1 +xref: KEGG_REACTION:R00540 +xref: MetaCyc:3.5.5.1-RXN +xref: RHEA:21724 +xref: UM-BBD_enzymeID:e0283 +is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles + +[Term] +id: GO:0000258 +name: obsolete isoleucine/valine:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "isoleucine/valine:sodium symporter activity" EXACT [] +is_obsolete: true +consider: GO:0005283 +consider: GO:0005304 +consider: GO:0015188 + +[Term] +id: GO:0000259 +name: obsolete intracellular nucleoside transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] +comment: This term was made obsolete because it contains component and function information. +synonym: "intracellular nucleoside transmembrane transporter activity" EXACT [] +is_obsolete: true +consider: GO:0005337 +consider: GO:0005622 + +[Term] +id: GO:0000260 +name: obsolete hydrogen-translocating V-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "hydrogen-translocating V-type ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046961 + +[Term] +id: GO:0000261 +name: obsolete sodium-translocating V-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "sodium-translocating V-type ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046962 + +[Term] +id: GO:0000262 +name: mitochondrial chromosome +namespace: cellular_component +def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] +synonym: "mitochondrial DNA" NARROW [] +synonym: "mitochondrial genome" RELATED [] +synonym: "mtDNA" NARROW [] +xref: NIF_Subcellular:sao1186327184 +is_a: GO:0005694 ! chromosome +relationship: part_of GO:0042645 ! mitochondrial nucleoid + +[Term] +id: GO:0000263 +name: obsolete heterotrimeric G-protein GTPase, alpha-subunit +namespace: molecular_function +def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "heterotrimeric G-protein GTPase, alpha-subunit" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000264 +name: obsolete heterotrimeric G-protein GTPase, beta-subunit +namespace: molecular_function +def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "heterotrimeric G-protein GTPase, beta-subunit" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000265 +name: obsolete heterotrimeric G-protein GTPase, gamma-subunit +namespace: molecular_function +def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "heterotrimeric G-protein GTPase, gamma-subunit" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0005834 + +[Term] +id: GO:0000266 +name: mitochondrial fission +namespace: biological_process +def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] +synonym: "mitochondrial division" EXACT [] +synonym: "mitochondrial proliferation" RELATED [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0000267 +name: obsolete cell fraction +namespace: cellular_component +def: "OBSOLETE. A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "cell fraction" EXACT [] +is_obsolete: true +consider: GO:0005575 + +[Term] +id: GO:0000268 +name: peroxisome targeting sequence binding +namespace: molecular_function +alt_id: GO:0005051 +def: "Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome." [GOC:mah, ISBN:0879693568] +synonym: "peroxisome targeting signal receptor" NARROW [] +synonym: "PTS binding" EXACT [] +synonym: "PTS receptor" NARROW [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0000269 +name: toxin export channel activity +namespace: molecular_function +def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +is_a: GO:0015288 ! porin activity +is_a: GO:0019534 ! toxin transmembrane transporter activity + +[Term] +id: GO:0000270 +name: peptidoglycan metabolic process +namespace: biological_process +alt_id: GO:0009284 +def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [ISBN:0198506732, PMID:33139480] +synonym: "murein metabolic process" EXACT [] +synonym: "murein metabolism" EXACT [] +synonym: "peptidoglycan metabolism" EXACT [] +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0000271 +name: polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:go_curators] +synonym: "glycan biosynthesis" EXACT [] +synonym: "glycan biosynthetic process" EXACT [] +synonym: "polysaccharide anabolism" EXACT [] +synonym: "polysaccharide biosynthesis" EXACT [] +synonym: "polysaccharide formation" EXACT [] +synonym: "polysaccharide synthesis" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0016051 ! carbohydrate biosynthetic process + +[Term] +id: GO:0000272 +name: polysaccharide catabolic process +namespace: biological_process +alt_id: GO:0044244 +def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:33139480] +synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] +synonym: "polysaccharide breakdown" EXACT [] +synonym: "polysaccharide catabolism" EXACT [] +synonym: "polysaccharide degradation" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0000274 +name: mitochondrial proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] +synonym: "mitochondrial proton-transporting ATP synthase, peripheral stalk" EXACT [] +is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0000275 +name: mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) +namespace: cellular_component +def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] +synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex + +[Term] +id: GO:0000276 +name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex + +[Term] +id: GO:0000277 +name: [cytochrome c]-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] +synonym: "cytochrome c (lysine) methyltransferase activity" RELATED [EC:2.1.1.59] +synonym: "cytochrome c methyltransferase activity" RELATED [EC:2.1.1.59] +synonym: "cytochrome c-lysine N-methyltransferase activity" RELATED [EC:2.1.1.59] +synonym: "cytochrome c-specific protein methylase III activity" RELATED [EC:2.1.1.59] +synonym: "cytochrome c-specific protein-lysine methyltransferase activity" RELATED [EC:2.1.1.59] +synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.59] +synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.59] +xref: EC:2.1.1.59 +xref: MetaCyc:2.1.1.59-RXN +xref: RHEA:24312 +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity + +[Term] +id: GO:0000278 +name: mitotic cell cycle +namespace: biological_process +alt_id: GO:0007067 +def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] +comment: Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_yeast +synonym: "mitosis" RELATED [] +xref: Wikipedia:Mitosis +is_a: GO:0007049 ! cell cycle + +[Term] +id: GO:0000279 +name: M phase +namespace: biological_process +def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "M-phase" EXACT [] +xref: Wikipedia:M_phase +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0000280 +name: nuclear division +namespace: biological_process +def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] +subset: goslim_pir +synonym: "karyokinesis" RELATED [] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0000281 +name: mitotic cytokinesis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] +subset: goslim_pombe +synonym: "cytokinesis after mitosis" EXACT [] +is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0000282 +name: cellular bud site selection +namespace: biological_process +def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] +comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). +synonym: "bud site selection/establishment of cell polarity" BROAD [] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:0000284 +name: obsolete shmoo orientation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. +synonym: "shmoo orientation" EXACT [] +is_obsolete: true +replaced_by: GO:0000753 + +[Term] +id: GO:0000285 +name: 1-phosphatidylinositol-3-phosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13609] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.150] +synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" RELATED [EC:2.7.1.150] +synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] +synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] +xref: EC:2.7.1.150 +xref: KEGG_REACTION:R05802 +xref: MetaCyc:2.7.1.150-RXN +xref: Reactome:R-HSA-1675910 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane" +xref: Reactome:R-HSA-1675921 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane" +xref: Reactome:R-HSA-1676134 "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane" +xref: Reactome:R-HSA-1676168 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane" +xref: RHEA:13609 +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0000286 +name: alanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1] +synonym: "AlaDH" RELATED [EC:1.4.1.1] +synonym: "alanine oxidoreductase activity" RELATED [EC:1.4.1.1] +synonym: "alpha-alanine dehydrogenase activity" RELATED [EC:1.4.1.1] +synonym: "L-alanine dehydrogenase activity" RELATED [EC:1.4.1.1] +synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.1] +synonym: "NAD-dependent alanine dehydrogenase activity" RELATED [EC:1.4.1.1] +synonym: "NAD-linked alanine dehydrogenase activity" RELATED [EC:1.4.1.1] +synonym: "NADH-dependent alanine dehydrogenase activity" RELATED [EC:1.4.1.1] +xref: EC:1.4.1.1 +xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN +xref: RHEA:18405 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0000287 +name: magnesium ion binding +namespace: molecular_function +def: "Binding to a magnesium (Mg) ion." [GOC:ai] +synonym: "magnesium binding" EXACT [] +synonym: "Mg binding" EXACT [] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0000288 +name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +namespace: biological_process +def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] +synonym: "deadenylation-dependent mRNA decay" EXACT [] +synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] +synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] +synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] +synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] +synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] +synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +is_a: GO:0061157 ! mRNA destabilization + +[Term] +id: GO:0000289 +name: nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] +synonym: "3' to 5' mRNA deadenylation" RELATED [] +synonym: "mRNA deadenylation" RELATED [] +synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:0000290 +name: deadenylation-dependent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] +synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] +synonym: "deadenylylation-dependent decapping" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +is_a: GO:0110156 ! methylguanosine-cap decapping +relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:0000291 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] +synonym: "exonucleolytic degradation of mRNA" EXACT [] +synonym: "mRNA breakdown, exonucleolytic" EXACT [] +synonym: "mRNA degradation, exonucleolytic" EXACT [] +synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000292 +name: RNA fragment catabolic process +namespace: biological_process +alt_id: GO:0030452 +def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] +synonym: "group I intron catabolic process" NARROW [] +synonym: "RNA fragment breakdown" EXACT [] +synonym: "RNA fragment catabolism" EXACT [GOC:mah] +synonym: "RNA fragment degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0000293 +name: ferric-chelate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor." [PMID:33559753] +synonym: "ferric chelate reductase activity" EXACT [] +synonym: "iron chelate reductase activity" EXACT [] +is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions + +[Term] +id: GO:0000294 +name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay +namespace: biological_process +def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] +synonym: "endonucleolytic mRNA decay" EXACT [] +synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] +synonym: "mRNA catabolic process, endonucleolytic" EXACT [] +synonym: "mRNA catabolism, endonucleolytic" EXACT [] +synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0000295 +name: adenine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870] +xref: Reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP" +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity + +[Term] +id: GO:0000296 +name: spermine transport +namespace: biological_process +def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] +is_a: GO:0006812 ! cation transport +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0000297 +name: spermine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0000298 +name: endopolyphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] +synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] +synonym: "polymetaphosphatase activity" RELATED [EC:3.6.1.10] +synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] +synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] +synonym: "polyphosphate polyphosphohydrolase activity" RELATED [EC:3.6.1.10] +xref: EC:3.6.1.10 +xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN +xref: RHEA:22452 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0000299 +name: obsolete integral to membrane of membrane fraction +namespace: cellular_component +def: "OBSOLETE. Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "integral to membrane of membrane fraction" EXACT [] +is_obsolete: true +consider: GO:0016021 + +[Term] +id: GO:0000300 +name: obsolete peripheral to membrane of membrane fraction +namespace: cellular_component +def: "OBSOLETE. Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "peripheral to membrane of membrane fraction" EXACT [] +is_obsolete: true +consider: GO:0019898 + +[Term] +id: GO:0000301 +name: retrograde transport, vesicle recycling within Golgi +namespace: biological_process +def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] +synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] +is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport + +[Term] +id: GO:0000302 +name: response to reactive oxygen species +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] +synonym: "response to active oxygen species" EXACT [] +synonym: "response to AOS" EXACT [] +synonym: "response to reactive oxidative species" EXACT [] +synonym: "response to reactive oxygen intermediate" EXACT [] +synonym: "response to ROI" EXACT [] +synonym: "response to ROS" EXACT [] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0000303 +name: response to superoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] +is_a: GO:0000305 ! response to oxygen radical + +[Term] +id: GO:0000304 +name: response to singlet oxygen +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0000305 +name: response to oxygen radical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0000306 +name: extrinsic component of vacuolar membrane +namespace: cellular_component +def: "The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] +synonym: "extrinsic to vacuolar membrane" EXACT [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0000307 +name: cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] +subset: goslim_pir +synonym: "CDK holoenzyme" EXACT [] +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0000308 +name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] +synonym: "CDK holoenzyme" BROAD [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000309 +name: nicotinamide-nucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] +synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" RELATED [EC:2.7.7.1] +synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] +synonym: "ATP:NMN adenylyltransferase activity" RELATED [EC:2.7.7.1] +synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] +synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "NAD+ diphosphorylase activity" RELATED [EC:2.7.7.1] +synonym: "NAD+ pyrophosphorylase activity" RELATED [EC:2.7.7.1] +synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] +synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] +synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] +synonym: "NMNAT activity" NARROW [EC:2.7.7.1] +xref: EC:2.7.7.1 +xref: MetaCyc:2.7.7.1-RXN +xref: Reactome:R-HSA-8939959 "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+" +xref: RHEA:21360 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0000310 +name: xanthine phosphoribosyltransferase activity +namespace: molecular_function +alt_id: GO:0009043 +def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt] +synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.22] +synonym: "Xan phosphoribosyltransferase activity" RELATED [EC:2.4.2.22] +synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] +synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.22] +synonym: "xanthylate pyrophosphorylase activity" RELATED [EC:2.4.2.22] +synonym: "xanthylic pyrophosphorylase activity" RELATED [EC:2.4.2.22] +synonym: "XMP pyrophosphorylase activity" RELATED [EC:2.4.2.22] +synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.22] +xref: EC:2.4.2.22 +xref: MetaCyc:XANPRIBOSYLTRAN-RXN +xref: RHEA:10800 +is_a: GO:0106130 ! purine phosphoribosyltransferase activity + +[Term] +id: GO:0000311 +name: plastid large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +is_a: GO:0000315 ! organellar large ribosomal subunit +relationship: part_of GO:0009547 ! plastid ribosome + +[Term] +id: GO:0000312 +name: plastid small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] +is_a: GO:0000314 ! organellar small ribosomal subunit +relationship: part_of GO:0009547 ! plastid ribosome + +[Term] +id: GO:0000313 +name: organellar ribosome +namespace: cellular_component +def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] +is_a: GO:0005840 ! ribosome +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0000314 +name: organellar small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] +is_a: GO:0015935 ! small ribosomal subunit +relationship: part_of GO:0000313 ! organellar ribosome + +[Term] +id: GO:0000315 +name: organellar large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +is_a: GO:0015934 ! large ribosomal subunit +relationship: part_of GO:0000313 ! organellar ribosome + +[Term] +id: GO:0000316 +name: sulfite transport +namespace: biological_process +def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "sulphite transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0000319 +name: sulfite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] +synonym: "sulphite transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0000320 +name: re-entry into mitotic cell cycle +namespace: biological_process +def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0000321 +name: re-entry into mitotic cell cycle after pheromone arrest +namespace: biological_process +def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] +is_a: GO:0000320 ! re-entry into mitotic cell cycle +is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + +[Term] +id: GO:0000322 +name: storage vacuole +namespace: cellular_component +def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000323 +name: lytic vacuole +namespace: cellular_component +def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000324 +name: fungal-type vacuole +namespace: cellular_component +def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] +synonym: "vacuole, cell cycle-correlated morphology" EXACT [] +is_a: GO:0000322 ! storage vacuole +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0000325 +name: plant-type vacuole +namespace: cellular_component +def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] +synonym: "vacuole, cell cycle-independent morphology" EXACT [] +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0000326 +name: protein storage vacuole +namespace: cellular_component +def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] +is_a: GO:0000322 ! storage vacuole +is_a: GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0000327 +name: lytic vacuole within protein storage vacuole +namespace: cellular_component +def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] +is_a: GO:0000323 ! lytic vacuole +relationship: part_of GO:0000326 ! protein storage vacuole + +[Term] +id: GO:0000328 +name: fungal-type vacuole lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] +synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0000324 ! fungal-type vacuole + +[Term] +id: GO:0000329 +name: fungal-type vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] +synonym: "fungal-type vacuolar membrane" RELATED [] +synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] +is_a: GO:0098852 ! lytic vacuole membrane +relationship: part_of GO:0000324 ! fungal-type vacuole + +[Term] +id: GO:0000330 +name: plant-type vacuole lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] +synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0000331 +name: contractile vacuole +namespace: cellular_component +def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory." [GOC:jl, PMID:10503189, PMID:23890380] +synonym: "central bladder" RELATED [PMID:23890380] +synonym: "central vacuole" RELATED [PMID:23890380] +xref: Wikipedia:Contractile_vacuole +is_a: GO:0005773 ! vacuole +is_a: GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0062159 ! contractile vacuole complex + +[Term] +id: GO:0000332 +name: template for synthesis of G-rich strand of telomere DNA activity +namespace: molecular_function +def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242, PMID:7958872] +comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. +synonym: "telomerase RNA" EXACT [] +synonym: "telomerase, template" EXACT [] +is_a: GO:0000497 ! DNA template activity +relationship: part_of GO:0003720 ! telomerase activity + +[Term] +id: GO:0000333 +name: telomerase catalytic core complex +namespace: cellular_component +def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [GOC:BHF-UCL, PMID:11884619, PMID:1808260] +synonym: "TERT-TERC complex" RELATED [GOC:nc, PMID:19701182] +is_a: GO:0005697 ! telomerase holoenzyme complex +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:0000334 +name: 3-hydroxyanthranilate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17953] +synonym: "3-hydroxyanthranilate oxygenase activity" RELATED [EC:1.13.11.6] +synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic acid dioxygenase activity" RELATED [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic acid oxygenase activity" RELATED [EC:1.13.11.6] +synonym: "3-hydroxyanthranilic oxygenase activity" RELATED [EC:1.13.11.6] +synonym: "3HAO" RELATED [EC:1.13.11.6] +xref: EC:1.13.11.6 +xref: KEGG_REACTION:R02665 +xref: MetaCyc:1.13.11.6-RXN +xref: Reactome:R-HSA-71218 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde" +xref: RHEA:17953 +xref: UM-BBD_reactionID:r1027 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0000335 +name: negative regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] +synonym: "down regulation of DNA transposition" EXACT [] +synonym: "down-regulation of DNA transposition" EXACT [] +synonym: "downregulation of DNA transposition" EXACT [] +synonym: "inhibition of DNA transposition" NARROW [] +synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] +is_a: GO:0000337 ! regulation of transposition, DNA-mediated +is_a: GO:0010529 ! negative regulation of transposition +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000336 +name: positive regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] +synonym: "activation of DNA transposition" NARROW [] +synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] +synonym: "stimulation of DNA transposition" NARROW [] +synonym: "up regulation of DNA transposition" EXACT [] +synonym: "up-regulation of DNA transposition" EXACT [] +synonym: "upregulation of DNA transposition" EXACT [] +is_a: GO:0000337 ! regulation of transposition, DNA-mediated +is_a: GO:0010530 ! positive regulation of transposition +is_a: GO:0045911 ! positive regulation of DNA recombination +relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000337 +name: regulation of transposition, DNA-mediated +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] +synonym: "regulation of DNA transposition" EXACT [GOC:dph] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0010528 ! regulation of transposition +relationship: regulates GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0000338 +name: protein deneddylation +namespace: biological_process +alt_id: GO:0010388 +def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] +synonym: "cullin deneddylation" NARROW [] +is_a: GO:0070646 ! protein modification by small protein removal + +[Term] +id: GO:0000339 +name: RNA cap binding +namespace: molecular_function +def: "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] +synonym: "binding to mRNA cap" NARROW [] +synonym: "mRNA cap binding" NARROW [] +synonym: "snRNA cap binding" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0000340 +name: RNA 7-methylguanosine cap binding +namespace: molecular_function +def: "Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] +synonym: "RNA m7G cap binding" EXACT [] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000341 +name: RNA trimethylguanosine cap binding +namespace: molecular_function +def: "Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] +synonym: "RNA m2,2,7G cap binding" EXACT [] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000342 +name: RNA cap 4 binding +namespace: molecular_function +def: "Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] +is_a: GO:0000339 ! RNA cap binding + +[Term] +id: GO:0000343 +name: plastid-encoded plastid RNA polymerase complex A +namespace: cellular_component +def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] +synonym: "PEP-A" EXACT [] +is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex + +[Term] +id: GO:0000344 +name: plastid-encoded plastid RNA polymerase complex B +namespace: cellular_component +def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] +synonym: "PEP-B" EXACT [] +is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex + +[Term] +id: GO:0000345 +name: cytosolic DNA-directed RNA polymerase complex +namespace: cellular_component +def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0000346 +name: transcription export complex +namespace: cellular_component +def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] +subset: goslim_pir +synonym: "TREX complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0000347 +name: THO complex +namespace: cellular_component +def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0000348 +name: mRNA branch site recognition +namespace: biological_process +alt_id: GO:0000370 +alt_id: GO:0000371 +def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). +synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw] +synonym: "spliceosomal A complex biosynthesis" NARROW [] +synonym: "spliceosomal A complex formation" NARROW [] +synonym: "spliceosomal B complex biosynthesis" NARROW [] +synonym: "spliceosomal B complex formation" NARROW [] +synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] +synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosomal complex assembly + +[Term] +id: GO:0000349 +name: generation of catalytic spliceosome for first transesterification step +namespace: biological_process +alt_id: GO:0000356 +alt_id: GO:0000357 +def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). +synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] +synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] +synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-2 complex formation" NARROW [] +synonym: "spliceosomal C1 complex biosynthesis" NARROW [] +synonym: "spliceosomal C1 complex formation" NARROW [] +synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] +synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000350 +name: generation of catalytic spliceosome for second transesterification step +namespace: biological_process +alt_id: GO:0000358 +alt_id: GO:0000359 +def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). +synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] +synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] +synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] +synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] +synonym: "formation of spliceosomal A2-2 complex" NARROW [] +synonym: "formation of spliceosomal C1 complex" NARROW [] +synonym: "lariat formation, 5'-splice site cleavage" RELATED [] +synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-3 complex formation" NARROW [] +synonym: "spliceosomal C2 complex biosynthesis" NARROW [] +synonym: "spliceosomal C2 complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000352 +name: trans assembly of SL-containing precatalytic spliceosome +namespace: biological_process +def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] +synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosomal complex assembly +relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition + +[Term] +id: GO:0000353 +name: formation of quadruple SL/U4/U5/U6 snRNP +namespace: biological_process +def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] +comment: Note that this step is analogous to 5' splice site selection in cis-splicing. +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition + +[Term] +id: GO:0000354 +name: cis assembly of pre-catalytic spliceosome +namespace: biological_process +alt_id: GO:0000360 +alt_id: GO:0000361 +def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] +comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). +synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] +synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] +synonym: "formation of spliceosomal A2-1 complex" NARROW [] +synonym: "formation of spliceosomal B1 complex" NARROW [] +synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] +synonym: "spliceosomal A2-1 complex formation" NARROW [] +synonym: "spliceosomal B1 complex biosynthesis" NARROW [] +synonym: "spliceosomal B1 complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosomal complex assembly +relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome + +[Term] +id: GO:0000362 +name: obsolete first U2-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "first U2-type spliceosomal transesterification activity" EXACT [] +synonym: "lariat formation, 5'-splice site cleavage" BROAD [] +is_obsolete: true +replaced_by: GO:0000384 + +[Term] +id: GO:0000363 +name: obsolete first U12-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "first U12-type spliceosomal transesterification activity" EXACT [] +synonym: "lariat formation, 5'-splice site cleavage" BROAD [] +is_obsolete: true +replaced_by: GO:0000384 + +[Term] +id: GO:0000364 +name: obsolete second U2-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "second U2-type spliceosomal transesterification activity" EXACT [] +is_obsolete: true +replaced_by: GO:0000386 + +[Term] +id: GO:0000365 +name: mRNA trans splicing, via spliceosome +namespace: biological_process +def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897, PMID:18458335] +synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw] +synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] +is_a: GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000366 +name: intergenic mRNA trans splicing +namespace: biological_process +def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] +synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw] +is_a: GO:0000365 ! mRNA trans splicing, via spliceosome +is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome + +[Term] +id: GO:0000367 +name: obsolete second U12-type spliceosomal transesterification activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] +comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "second U12-type spliceosomal transesterification activity" EXACT [] +is_obsolete: true +replaced_by: GO:0000386 + +[Term] +id: GO:0000372 +name: Group I intron splicing +namespace: biological_process +def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] +comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). +synonym: "mRNA splicing" RELATED [] +is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile + +[Term] +id: GO:0000373 +name: Group II intron splicing +namespace: biological_process +def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] +comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. +synonym: "mRNA splicing" RELATED [] +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile + +[Term] +id: GO:0000374 +name: Group III intron splicing +namespace: biological_process +def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] +comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. +synonym: "mRNA splicing" RELATED [] +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile + +[Term] +id: GO:0000375 +name: RNA splicing, via transesterification reactions +namespace: biological_process +alt_id: GO:0000385 +alt_id: GO:0031202 +def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] +comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. +subset: goslim_pir +synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] +synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] +synonym: "spliceosomal catalysis" RELATED [] +is_a: GO:0008380 ! RNA splicing + +[Term] +id: GO:0000376 +name: RNA splicing, via transesterification reactions with guanosine as nucleophile +namespace: biological_process +def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] +is_a: GO:0000375 ! RNA splicing, via transesterification reactions + +[Term] +id: GO:0000377 +name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile +namespace: biological_process +def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] +synonym: "lariat RNA biosynthesis" RELATED [] +synonym: "lariat RNA formation" RELATED [] +is_a: GO:0000375 ! RNA splicing, via transesterification reactions + +[Term] +id: GO:0000378 +name: RNA exon ligation +namespace: biological_process +def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] +comment: Note that this is not a part of spliceosomal RNA splicing. +is_a: GO:0016070 ! RNA metabolic process +relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0000379 +name: tRNA-type intron splice site recognition and cleavage +namespace: biological_process +def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0000380 +name: alternative mRNA splicing, via spliceosome +namespace: biological_process +def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] +comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. +synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] +synonym: "splice site selection" BROAD [] +is_a: GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000381 +name: regulation of alternative mRNA splicing, via spliceosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] +synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] +synonym: "splice site selection" BROAD [] +is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome +relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome + +[Term] +id: GO:0000384 +name: first spliceosomal transesterification activity +namespace: molecular_function +def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] +synonym: "lariat formation, 5'-splice site cleavage" RELATED [] +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0000386 +name: second spliceosomal transesterification activity +namespace: molecular_function +def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "lariat formation, 5'-splice site cleavage" RELATED [] +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0000387 +name: spliceosomal snRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000388 +name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) +namespace: biological_process +alt_id: GO:0000396 +alt_id: GO:0000397 +def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +synonym: "spliceosomal A1 complex biosynthesis" NARROW [] +synonym: "spliceosomal A1 complex formation" NARROW [] +synonym: "spliceosomal B2 complex biosynthesis" NARROW [] +synonym: "spliceosomal B2 complex formation" NARROW [] +synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] +synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation + +[Term] +id: GO:0000389 +name: mRNA 3'-splice site recognition +namespace: biological_process +alt_id: GO:0000382 +alt_id: GO:0000383 +def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] +synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw] +synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] +is_a: GO:0006376 ! mRNA splice site selection + +[Term] +id: GO:0000390 +name: spliceosomal complex disassembly +namespace: biological_process +alt_id: GO:0000391 +alt_id: GO:0000392 +def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] +synonym: "spliceosome complex disassembly" EXACT [] +synonym: "spliceosome disassembly" BROAD [] +synonym: "U12-type spliceosome disassembly" NARROW [] +synonym: "U2-type spliceosome disassembly" NARROW [] +is_a: GO:0032988 ! ribonucleoprotein complex disassembly +relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000393 +name: spliceosomal conformational changes to generate catalytic conformation +namespace: biological_process +def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] +synonym: "3'-splice site cleavage, exon ligation" BROAD [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0000394 +name: RNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] +comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +synonym: "mRNA splicing" BROAD [] +is_a: GO:0008380 ! RNA splicing + +[Term] +id: GO:0000395 +name: mRNA 5'-splice site recognition +namespace: biological_process +alt_id: GO:0000368 +alt_id: GO:0000369 +def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). +synonym: "nuclear mRNA 5' splice site recognition" EXACT [] +synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw] +synonym: "spliceosomal CC complex biosynthesis" NARROW [] +synonym: "spliceosomal CC complex formation" NARROW [] +synonym: "spliceosomal commitment complex biosynthesis" NARROW [] +synonym: "spliceosomal commitment complex formation" NARROW [] +synonym: "spliceosomal E complex biosynthesis" NARROW [] +synonym: "spliceosomal E complex formation" NARROW [] +synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] +synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] +synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] +is_a: GO:0006376 ! mRNA splice site selection +relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome + +[Term] +id: GO:0000398 +name: mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0006374 +alt_id: GO:0006375 +def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] +comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. +synonym: "mRNA splicing" BROAD [] +synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] +synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw] +synonym: "pre-mRNA splicing" BROAD [] +synonym: "splicing AT-AC intron" RELATED [] +synonym: "splicing GT-AG intron" RELATED [] +is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0000399 +name: cellular bud neck septin structure +namespace: cellular_component +def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005935 ! cellular bud neck +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0000400 +name: four-way junction DNA binding +namespace: molecular_function +def: "Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "forked DNA binding" BROAD [] +synonym: "Holliday junction binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000401 +name: open form four-way junction DNA binding +namespace: molecular_function +def: "Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "open form Holliday junction binding" EXACT [] +is_a: GO:0000400 ! four-way junction DNA binding + +[Term] +id: GO:0000402 +name: crossed form four-way junction DNA binding +namespace: molecular_function +def: "Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] +synonym: "crossed form Holliday junction binding" EXACT [] +is_a: GO:0000400 ! four-way junction DNA binding + +[Term] +id: GO:0000403 +name: Y-form DNA binding +namespace: molecular_function +def: "Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] +synonym: "forked DNA binding" BROAD [] +synonym: "splayed Y-form DNA binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000404 +name: heteroduplex DNA loop binding +namespace: molecular_function +def: "Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] +synonym: "loop DNA binding" RELATED [GOC:jh] +is_a: GO:0000217 ! DNA secondary structure binding +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0000405 +name: bubble DNA binding +namespace: molecular_function +def: "Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000406 +name: double-strand/single-strand DNA junction binding +namespace: molecular_function +def: "Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0000407 +name: phagophore assembly site +namespace: cellular_component +def: "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] +synonym: "PAS" EXACT [] +synonym: "perivacuolar space" NARROW [] +synonym: "pre-autophagosomal structure" NARROW [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000408 +name: EKC/KEOPS complex +namespace: cellular_component +def: "A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934] +comment: Originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. +synonym: "endopeptidase-like kinase chromatin-associated protein complex" EXACT [] +synonym: "KEOPS/EKC complex" EXACT [PMID:21183954, PMID:23945934] +synonym: "kinase, putative endopeptidase and other proteins of small size protein complex" EXACT [] +synonym: "TCTC" RELATED [PMID:25629598] +synonym: "threonyl-carbamoly transferase complex" RELATED [PMID:25629598] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0000409 +name: regulation of transcription by galactose +namespace: biological_process +def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] +is_a: GO:0006355 ! regulation of transcription, DNA-templated + +[Term] +id: GO:0000410 +name: carbon catabolite repression of transcription by galactose +namespace: biological_process +def: "A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah] +synonym: "down regulation of transcription by galactose" EXACT [] +synonym: "down-regulation of transcription by galactose" EXACT [] +synonym: "downregulation of transcription by galactose" EXACT [] +synonym: "inhibition of transcription by galactose" NARROW [] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0045013 ! carbon catabolite repression of transcription + +[Term] +id: GO:0000411 +name: positive regulation of transcription by galactose +namespace: biological_process +def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] +synonym: "activation of transcription by galactose" NARROW [] +synonym: "stimulation of transcription by galactose" NARROW [] +synonym: "up regulation of transcription by galactose" EXACT [] +synonym: "up-regulation of transcription by galactose" EXACT [] +synonym: "upregulation of transcription by galactose" EXACT [] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0045991 ! carbon catabolite activation of transcription + +[Term] +id: GO:0000412 +name: histone peptidyl-prolyl isomerization +namespace: biological_process +def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] +synonym: "histone proline isomerization" EXACT [] +is_a: GO:0000413 ! protein peptidyl-prolyl isomerization +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0000413 +name: protein peptidyl-prolyl isomerization +namespace: biological_process +def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] +synonym: "protein proline isomerization" EXACT [] +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0000414 +name: regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000415 +name: negative regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +synonym: "down regulation of histone H3-K36 methylation" EXACT [] +synonym: "down-regulation of histone H3-K36 methylation" EXACT [] +synonym: "downregulation of histone H3-K36 methylation" EXACT [] +synonym: "inhibition of histone H3-K36 methylation" NARROW [] +is_a: GO:0000414 ! regulation of histone H3-K36 methylation +is_a: GO:0031061 ! negative regulation of histone methylation +relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000416 +name: positive regulation of histone H3-K36 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] +synonym: "activation of histone H3-K36 methylation" NARROW [] +synonym: "stimulation of histone H3-K36 methylation" NARROW [] +synonym: "up regulation of histone H3-K36 methylation" EXACT [] +synonym: "up-regulation of histone H3-K36 methylation" EXACT [] +synonym: "upregulation of histone H3-K36 methylation" EXACT [] +is_a: GO:0000414 ! regulation of histone H3-K36 methylation +is_a: GO:0031062 ! positive regulation of histone methylation +relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation + +[Term] +id: GO:0000417 +name: HIR complex +namespace: cellular_component +def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] +synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0000418 +name: RNA polymerase IV complex +namespace: cellular_component +alt_id: GO:0000420 +def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] +synonym: "DNA-directed RNA polymerase IV complex" EXACT [] +synonym: "DNA-directed RNA polymerase IVa complex" EXACT [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0000419 +name: RNA polymerase V complex +namespace: cellular_component +alt_id: GO:0080137 +def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459] +synonym: "DNA-directed RNA polymerase IVb complex" EXACT [] +synonym: "DNA-directed RNA polymerase V complex" EXACT [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0000421 +name: autophagosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete] +synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0005776 ! autophagosome + +[Term] +id: GO:0000422 +name: autophagy of mitochondrion +namespace: biological_process +def: "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] +synonym: "mitochondrion autophagy" EXACT [GOC:autophagy] +synonym: "mitophagy" RELATED [] +xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy +xref: Wikipedia:Mitophagy +is_a: GO:0006914 ! autophagy +is_a: GO:0061726 ! mitochondrion disassembly + +[Term] +id: GO:0000423 +name: mitophagy +namespace: biological_process +def: "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367] +comment: Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes. +synonym: "macromitophagy" EXACT [] +is_a: GO:0000422 ! autophagy of mitochondrion +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0000424 +name: micromitophagy +namespace: biological_process +def: "Degradation of a mitochondrion by lysosomal microautophagy." [PMID:15798367, PMID:27003723] +comment: Note that this term is not a child of mitophagy because the community genrally uses that latter to refer to the macroautophagy of mitochondria. +is_a: GO:0000422 ! autophagy of mitochondrion +is_a: GO:0016237 ! lysosomal microautophagy + +[Term] +id: GO:0000425 +name: pexophagy +namespace: biological_process +def: "The selective autophagy process in which a peroxisome is degraded by macroautophagy." [GOC:autophagy, PMID:12914914, PMID:16973210] +synonym: "macropexophagy" EXACT [] +is_a: GO:0030242 ! autophagy of peroxisome +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0000426 +name: micropexophagy +namespace: biological_process +def: "Degradation of a peroxisome by lysosomal microautophagy." [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210] +comment: Note that this term is not a child of pexophagy because the community usually uses the latter to refer to the macroautohagy process. +is_a: GO:0016237 ! lysosomal microautophagy +is_a: GO:0030242 ! autophagy of peroxisome + +[Term] +id: GO:0000427 +name: plastid-encoded plastid RNA polymerase complex +namespace: cellular_component +def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0000428 +name: DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] +is_a: GO:0030880 ! RNA polymerase complex + +[Term] +id: GO:0000429 +name: carbon catabolite regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah] +synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0045990 ! carbon catabolite regulation of transcription + +[Term] +id: GO:0000430 +name: regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0000431 +name: regulation of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +is_a: GO:0000409 ! regulation of transcription by galactose +is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0000432 +name: positive regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose +is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter +is_a: GO:0046016 ! positive regulation of transcription by glucose + +[Term] +id: GO:0000433 +name: carbon catabolite repression of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:krc] +synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] +is_a: GO:0045014 ! carbon catabolite repression of transcription by glucose +is_a: GO:0061987 ! negative regulation of transcription from RNA polymerase II promoter by glucose + +[Term] +id: GO:0000434 +name: carbon catabolite repression of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] +is_a: GO:0000410 ! carbon catabolite repression of transcription by galactose +is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose +is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter + +[Term] +id: GO:0000435 +name: positive regulation of transcription from RNA polymerase II promoter by galactose +namespace: biological_process +def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] +is_a: GO:0000411 ! positive regulation of transcription by galactose +is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose +is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0000436 +name: carbon catabolite activation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] +synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0045991 ! carbon catabolite activation of transcription + +[Term] +id: GO:0000437 +name: carbon catabolite repression of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc] +synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter +is_a: GO:0045013 ! carbon catabolite repression of transcription + +[Term] +id: GO:0000438 +name: core TFIIH complex portion of holo TFIIH complex +namespace: cellular_component +alt_id: GO:0000443 +def: "The core TFIIH complex when it is part of the general transcription factor TFIIH." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] +synonym: "SSL2-core TFIIH complex portion of holo TFIIH complex" EXACT [] +is_a: GO:0000439 ! transcription factor TFIIH core complex +relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex + +[Term] +id: GO:0000439 +name: transcription factor TFIIH core complex +namespace: cellular_component +alt_id: GO:0000441 +def: "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] +subset: goslim_pir +synonym: "core TFIIH complex" EXACT [] +synonym: "SSL2-core TFIIH complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0000440 +name: core TFIIH complex portion of NEF3 complex +namespace: cellular_component +alt_id: GO:0000442 +def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] +synonym: "SSL2-core TFIIH complex portion of NEF3 complex" EXACT [] +is_a: GO:0000439 ! transcription factor TFIIH core complex +relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex + +[Term] +id: GO:0000444 +name: MIS12/MIND type complex +namespace: cellular_component +def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] +synonym: "Mis12 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0000445 +name: THO complex part of transcription export complex +namespace: cellular_component +def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] +synonym: "THO complex part of TREX complex" EXACT [] +is_a: GO:0000347 ! THO complex +relationship: part_of GO:0000346 ! transcription export complex + +[Term] +id: GO:0000446 +name: nucleoplasmic THO complex +namespace: cellular_component +def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072] +is_a: GO:0000347 ! THO complex +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0000447 +name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "endonucleolytic cleavage at A2" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000448 +name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +alt_id: GO:0000490 +def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "cleavage at C2" RELATED [] +synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000449 +name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing + +[Term] +id: GO:0000450 +name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing + +[Term] +id: GO:0000451 +name: rRNA 2'-O-methylation +namespace: biological_process +def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337] +is_a: GO:0031167 ! rRNA methylation + +[Term] +id: GO:0000452 +name: snoRNA guided rRNA 2'-O-methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337] +synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0000451 ! rRNA 2'-O-methylation + +[Term] +id: GO:0000453 +name: enzyme-directed rRNA 2'-O-methylation +namespace: biological_process +def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337] +is_a: GO:0000451 ! rRNA 2'-O-methylation + +[Term] +id: GO:0000454 +name: snoRNA guided rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337] +is_a: GO:0031118 ! rRNA pseudouridine synthesis + +[Term] +id: GO:0000455 +name: enzyme-directed rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337] +is_a: GO:0031118 ! rRNA pseudouridine synthesis + +[Term] +id: GO:0000456 +name: obsolete dimethylation involved in SSU-rRNA maturation +namespace: biological_process +def: "OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337] +comment: The reason for obsoletion is that this term can be captured as a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0000457 +name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) + +[Term] +id: GO:0000458 +name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +namespace: biological_process +def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) +relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) + +[Term] +id: GO:0000459 +name: exonucleolytic trimming involved in rRNA processing +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] +synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000469 ! cleavage involved in rRNA processing +is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic + +[Term] +id: GO:0000460 +name: maturation of 5.8S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000461 +name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] +synonym: "endonucleolytic cleavage at site D" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000462 +name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +alt_id: GO:1990041 +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +synonym: "maturation of 18S rRNA" NARROW [] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000463 +name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000464 +name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] +synonym: "endonucleolytic cleavage at A3" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000465 +name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000466 +name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +is_a: GO:0000460 ! maturation of 5.8S rRNA + +[Term] +id: GO:0000467 +name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000468 +name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] +synonym: "processing at B2" NARROW [] +is_a: GO:0031125 ! rRNA 3'-end processing +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000469 +name: cleavage involved in rRNA processing +namespace: biological_process +def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] +synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] +is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis +relationship: part_of GO:0006364 ! rRNA processing + +[Term] +id: GO:0000470 +name: maturation of LSU-rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing +relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis + +[Term] +id: GO:0000471 +name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000472 +name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] +synonym: "endonucleolytic cleavage at A1" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000473 +name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000474 +name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000475 +name: maturation of 2S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000476 +name: maturation of 4.5S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000477 +name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] +synonym: "processing at C1" NARROW [] +is_a: GO:0000469 ! cleavage involved in rRNA processing +is_a: GO:0000967 ! rRNA 5'-end processing +relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000478 +name: endonucleolytic cleavage involved in rRNA processing +namespace: biological_process +def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] +synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000469 ! cleavage involved in rRNA processing +is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic + +[Term] +id: GO:0000479 +name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] +is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing + +[Term] +id: GO:0000480 +name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] +synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] +synonym: "endonucleolytic cleavage at A0" NARROW [] +is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) + +[Term] +id: GO:0000481 +name: maturation of 5S rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:0000482 +name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000481 ! maturation of 5S rRNA + +[Term] +id: GO:0000483 +name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing + +[Term] +id: GO:0000484 +name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) + +[Term] +id: GO:0000485 +name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000475 ! maturation of 2S rRNA + +[Term] +id: GO:0000486 +name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] +is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +relationship: part_of GO:0000475 ! maturation of 2S rRNA +relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) + +[Term] +id: GO:0000487 +name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000460 ! maturation of 5.8S rRNA + +[Term] +id: GO:0000488 +name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0000489 +name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0000491 +name: small nucleolar ribonucleoprotein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] +synonym: "snoRNP assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:0000492 +name: box C/D snoRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] +synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] +is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly + +[Term] +id: GO:0000493 +name: box H/ACA snoRNP assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] +synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] +is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly + +[Term] +id: GO:0000494 +name: box C/D RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a box C/D RNA molecule." [GOC:krc] +synonym: "box C/D RNA 3' end processing" EXACT [] +synonym: "box C/D snoRNA 3'-end processing" NARROW [] +synonym: "box C/D sRNA 3'-end processing" NARROW [] +is_a: GO:0031126 ! sno(s)RNA 3'-end processing +is_a: GO:0034963 ! box C/D RNA processing + +[Term] +id: GO:0000495 +name: box H/ACA RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a box H/ACA RNA molecule." [GOC:krc] +synonym: "box H/ACA RNA 3' end processing" EXACT [] +synonym: "box H/ACA snoRNA 3'-end processing" NARROW [] +synonym: "box H/ACA sRNA 3'-end processing" NARROW [] +is_a: GO:0031126 ! sno(s)RNA 3'-end processing +is_a: GO:0034964 ! box H/ACA RNA processing + +[Term] +id: GO:0000497 +name: DNA template activity +namespace: molecular_function +def: "Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] +comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. +synonym: "base pairing with DNA" RELATED [] +is_a: GO:0003677 ! DNA binding +is_a: GO:0140489 ! molecular template activity + +[Term] +id: GO:0000500 +name: RNA polymerase I upstream activating factor complex +namespace: cellular_component +def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] +synonym: "RNA polymerase I upstream activation factor complex" EXACT [] +synonym: "UAF" EXACT [] +is_a: GO:0000120 ! RNA polymerase I transcription regulator complex + +[Term] +id: GO:0000502 +name: proteasome complex +namespace: cellular_component +def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, Wikipedia:Proteasome] +subset: goslim_pir +synonym: "26S proteasome" NARROW [] +synonym: "proteasome" EXACT [GOC:cjm] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1905369 ! endopeptidase complex + +[Term] +id: GO:0000504 +name: obsolete proteasome regulatory particle (sensu Bacteria) +namespace: cellular_component +def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] +comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. +synonym: "26S proteasome" NARROW [] +synonym: "proteasome regulatory particle (sensu Bacteria)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000506 +name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] +comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. +synonym: "GPI-GlcNAc transferase complex" EXACT [] +synonym: "GPI-GnT complex" EXACT [] +synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0000578 +name: embryonic axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] +synonym: "embryonic axis determination" RELATED [] +is_a: GO:0009798 ! axis specification +is_a: GO:0009880 ! embryonic pattern specification + +[Term] +id: GO:0000700 +name: mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000701 +name: purine-specific mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] +synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] +xref: EC:3.2.2.31 +is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0000702 +name: oxidized base lesion DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000703 +name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0019004 +def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] +comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. +synonym: "bifunctional DNA glycosylase" BROAD [] +synonym: "DNA glycosylase/AP-lyase" BROAD [] +synonym: "DNA glycosylase/beta-lyase" BROAD [] +synonym: "endodeoxyribonuclease III" RELATED [] +synonym: "endonuclease III" RELATED [] +synonym: "endonuclease VIII activity" RELATED [] +synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators] +synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] +xref: Reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase" +xref: Reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase" +xref: Reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase" +is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity + +[Term] +id: GO:0000704 +name: pyrimidine dimer DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0000705 +name: achiasmate meiosis I +namespace: biological_process +def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] +synonym: "achiasmate meiosis I nuclear division" EXACT [] +is_a: GO:0007127 ! meiosis I + +[Term] +id: GO:0000706 +name: meiotic DNA double-strand break processing +namespace: biological_process +def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] +is_a: GO:0000729 ! DNA double-strand break processing +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0000707 +name: meiotic DNA recombinase assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] +is_a: GO:0000730 ! DNA recombinase assembly +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0000708 +name: meiotic strand invasion +namespace: biological_process +def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] +synonym: "meiotic D-loop biosynthesis" RELATED [] +synonym: "meiotic D-loop formation" RELATED [] +synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] +synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw] +is_a: GO:0042148 ! strand invasion +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0000709 +name: meiotic joint molecule formation +namespace: biological_process +def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0000710 +name: meiotic mismatch repair +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] +is_a: GO:0006298 ! mismatch repair +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0000711 +name: meiotic DNA repair synthesis +namespace: biological_process +def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] +is_a: GO:0000731 ! DNA synthesis involved in DNA repair +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0000712 +name: resolution of meiotic recombination intermediates +namespace: biological_process +def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] +synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] +is_a: GO:0061982 ! meiosis I cell cycle process +relationship: part_of GO:0007131 ! reciprocal meiotic recombination +relationship: part_of GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0000713 +name: meiotic heteroduplex formation +namespace: biological_process +def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] +is_a: GO:0061982 ! meiosis I cell cycle process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0000714 +name: meiotic strand displacement +namespace: biological_process +def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] +synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] +synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] +synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] +synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] +is_a: GO:0000732 ! strand displacement +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0000715 +name: nucleotide-excision repair, DNA damage recognition +namespace: biological_process +def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] +synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000716 +name: transcription-coupled nucleotide-excision repair, DNA damage recognition +namespace: biological_process +def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] +synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] +is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition +relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair + +[Term] +id: GO:0000717 +name: nucleotide-excision repair, DNA duplex unwinding +namespace: biological_process +def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] +is_a: GO:0032508 ! DNA duplex unwinding +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000718 +name: nucleotide-excision repair, DNA damage removal +namespace: biological_process +def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] +is_a: GO:0044349 ! DNA excision +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0000719 +name: photoreactive repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] +synonym: "pyrimidine-dimer repair by photolyase" NARROW [] +is_a: GO:0006290 ! pyrimidine dimer repair + +[Term] +id: GO:0000720 +name: pyrimidine dimer repair by nucleotide-excision repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] +comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. +is_a: GO:0006289 ! nucleotide-excision repair +is_a: GO:0006290 ! pyrimidine dimer repair + +[Term] +id: GO:0000721 +name: (R,R)-butanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4] +synonym: "(R)-2,3-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "(R)-diacetyl reductase activity" RELATED [EC:1.1.1.4] +synonym: "1-amino-2-propanol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "1-amino-2-propanol oxidoreductase activity" RELATED [EC:1.1.1.4] +synonym: "2,3-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "aminopropanol oxidoreductase activity" RELATED [EC:1.1.1.4] +synonym: "butylene glycol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "butyleneglycol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "D-(-)-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "D-1-amino-2-propanol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" RELATED [EC:1.1.1.4] +synonym: "D-aminopropanol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "D-butanediol dehydrogenase activity" RELATED [EC:1.1.1.4] +synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] +xref: EC:1.1.1.4 +xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN +xref: RHEA:24340 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0000722 +name: telomere maintenance via recombination +namespace: biological_process +def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] +synonym: "telomerase-independent telomere maintenance" RELATED [] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006312 ! mitotic recombination + +[Term] +id: GO:0000723 +name: telomere maintenance +namespace: biological_process +def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] +synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0032200 ! telomere organization + +[Term] +id: GO:0000724 +name: double-strand break repair via homologous recombination +namespace: biological_process +alt_id: GO:0016924 +def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] +synonym: "HDR" EXACT [GOC:vk] +synonym: "homologous recombinational repair" EXACT [] +synonym: "homology-directed repair" EXACT [GOC:vk] +synonym: "HRR" EXACT [] +synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] +synonym: "Rhp51-dependent recombinational repair" EXACT [] +is_a: GO:0000725 ! recombinational repair +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0000725 +name: recombinational repair +namespace: biological_process +def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] +xref: Wikipedia:Recombinational_repair +is_a: GO:0006281 ! DNA repair +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0000726 +name: obsolete non-recombinational repair +namespace: biological_process +def: "OBSOLETE. A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:elh] +comment: This term was obsoleted because it was defined negatively, and it represents an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0000727 +name: double-strand break repair via break-induced replication +namespace: biological_process +def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0000729 +name: DNA double-strand break processing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006302 ! double-strand break repair + +[Term] +id: GO:0000730 +name: DNA recombinase assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] +synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] +is_a: GO:0065004 ! protein-DNA complex assembly +is_a: GO:0090735 ! DNA repair complex assembly +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0000731 +name: DNA synthesis involved in DNA repair +namespace: biological_process +def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] +synonym: "DNA repair synthesis" BROAD [] +synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] +synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah] +is_a: GO:0071897 ! DNA biosynthetic process +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:0000732 +name: strand displacement +namespace: biological_process +def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] +synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] +synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] +synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] +synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0000733 +name: obsolete DNA strand renaturation +namespace: biological_process +def: "OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0036310 + +[Term] +id: GO:0000735 +name: removal of nonhomologous ends +namespace: biological_process +def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0000736 +name: double-strand break repair via single-strand annealing, removal of nonhomologous ends +namespace: biological_process +def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] +is_a: GO:0000735 ! removal of nonhomologous ends +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0000737 +name: DNA catabolic process, endonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] +synonym: "DNA breakdown, endonucleolytic" EXACT [] +synonym: "DNA degradation, endonucleolytic" EXACT [] +synonym: "endonucleolytic degradation of DNA" EXACT [] +synonym: "endonucleolytic DNA catabolism" EXACT [] +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis + +[Term] +id: GO:0000738 +name: DNA catabolic process, exonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] +synonym: "DNA breakdown, exonucleolytic" EXACT [] +synonym: "DNA degradation, exonucleolytic" EXACT [] +synonym: "exonucleolytic degradation of DNA" EXACT [] +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis + +[Term] +id: GO:0000739 +name: obsolete DNA strand annealing activity +namespace: molecular_function +def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] +comment: This term was made obsolete because it describes a process and not an activity. +synonym: "DNA strand annealing activity" EXACT [] +is_obsolete: true +consider: GO:0036292 +consider: GO:0036310 + +[Term] +id: GO:0000740 +name: nuclear membrane fusion +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] +is_a: GO:0071763 ! nuclear membrane organization +is_a: GO:0090174 ! organelle membrane fusion + +[Term] +id: GO:0000741 +name: karyogamy +namespace: biological_process +alt_id: GO:0007335 +def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] +synonym: "nuclear fusion" EXACT [] +synonym: "nuclear fusion during karyogamy" EXACT [] +xref: Wikipedia:Karyogamy +is_a: GO:0006997 ! nucleus organization +is_a: GO:0048284 ! organelle fusion + +[Term] +id: GO:0000742 +name: karyogamy involved in conjugation with cellular fusion +namespace: biological_process +def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] +synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000741 ! karyogamy +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000743 +name: nuclear migration involved in conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0006946 +def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440] +synonym: "nuclear congression" EXACT [GOC:vw] +synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022414 ! reproductive process +is_a: GO:0030473 ! nuclear migration along microtubule +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000744 +name: karyogamy involved in conjugation with mutual genetic exchange +namespace: biological_process +def: "During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena." [GOC:mah, GOC:pg] +synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000745 +name: nuclear migration involved in conjugation with mutual genetic exchange +namespace: biological_process +def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] +synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] +synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange + +[Term] +id: GO:0000746 +name: conjugation +namespace: biological_process +def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +xref: Wikipedia:Conjugation +is_a: GO:0044764 ! multi-organism cellular process + +[Term] +id: GO:0000747 +name: conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007322 +alt_id: GO:0007333 +alt_id: GO:0030461 +alt_id: GO:0030477 +def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] +subset: goslim_pombe +synonym: "cell fusion" RELATED [] +synonym: "mating" RELATED [] +is_a: GO:0000746 ! conjugation +is_a: GO:0019953 ! sexual reproduction +is_a: GO:0140253 ! cell-cell fusion + +[Term] +id: GO:0000748 +name: conjugation with mutual genetic exchange +namespace: biological_process +def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] +synonym: "conjugation without cellular fusion" EXACT [] +is_a: GO:0000746 ! conjugation + +[Term] +id: GO:0000749 +name: response to pheromone triggering conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007328 +alt_id: GO:0030434 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] +synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] +is_a: GO:0071444 ! cellular response to pheromone +relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000750 +name: pheromone-dependent signal transduction involved in conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007330 +alt_id: GO:0030454 +def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] +synonym: "transduction of mating signal" BROAD [] +is_a: GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion +relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion + +[Term] +id: GO:0000751 +name: mitotic cell cycle G1 arrest in response to pheromone +namespace: biological_process +alt_id: GO:0030571 +def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] +synonym: "cell cycle arrest in response to pheromone" BROAD [] +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion + +[Term] +id: GO:0000752 +name: agglutination involved in conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007334 +def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] +synonym: "agglutination" BROAD [] +synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] +synonym: "cell-cell adhesion during mating" EXACT [] +is_a: GO:0000771 ! agglutination involved in conjugation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0000747 ! conjugation with cellular fusion +relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion + +[Term] +id: GO:0000753 +name: cell morphogenesis involved in conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007332 +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] +synonym: "shmoo orientation" NARROW [] +synonym: "shmooing" NARROW [] +is_a: GO:0000767 ! cell morphogenesis involved in conjugation +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000754 +name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion +namespace: biological_process +alt_id: GO:0007331 +alt_id: GO:0030453 +def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] +synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] +synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] +synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] +is_a: GO:0023058 ! adaptation of signaling pathway +relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion + +[Term] +id: GO:0000755 +name: cytogamy +namespace: biological_process +alt_id: GO:0000218 +alt_id: GO:0030462 +def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] +synonym: "zygote formation" RELATED [] +is_a: GO:0022413 ! reproductive process in single-celled organism +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0000756 +name: response to pheromone regulating conjugation with mutual genetic exchange +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion." [GOC:clt] +synonym: "response to pheromone triggering conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007154 ! cell communication +is_a: GO:0071444 ! cellular response to pheromone +relationship: regulates GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000757 +name: obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange +namespace: biological_process +def: "OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] +comment: This term was obsoleted because its label and definitions were not clear. It had never been used for annotation. +synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0000758 +name: agglutination involved in conjugation with mutual genetic exchange +namespace: biological_process +def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism." [GOC:elh] +synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +synonym: "sexual flocculation" EXACT [] +is_a: GO:0000771 ! agglutination involved in conjugation +relationship: part_of GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange + +[Term] +id: GO:0000759 +name: obsolete cell morphogenesis involved in conjugation with mutual genetic exchange +namespace: biological_process +def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0000760 +name: adaptation to pheromone regulating conjugation with mutual genetic exchange +namespace: biological_process +def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] +synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] +synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] +is_a: GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange +is_a: GO:0022401 ! negative adaptation of signaling pathway +is_a: GO:0046999 ! regulation of conjugation + +[Term] +id: GO:0000761 +name: conjugant formation +namespace: biological_process +def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] +is_a: GO:0000771 ! agglutination involved in conjugation +relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange + +[Term] +id: GO:0000762 +name: pheromone-induced unidirectional conjugation +namespace: biological_process +def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] +is_a: GO:0009291 ! unidirectional conjugation + +[Term] +id: GO:0000763 +name: obsolete cell morphogenesis involved in unidirectional conjugation +namespace: biological_process +def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] +comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. +synonym: "cell morphogenesis involved in unidirectional conjugation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000764 +name: obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation +namespace: biological_process +def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] +comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. +synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] +synonym: "cellular morphogenesis involved in pheromone-induced unidirectional conjugation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0000765 +name: response to pheromone regulating pheromone-induced unidirectional conjugation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation." [GOC:clt] +synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] +is_a: GO:0019236 ! response to pheromone +relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation + +[Term] +id: GO:0000766 +name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation +namespace: biological_process +def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] +synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] +synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] +synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] +is_a: GO:0022401 ! negative adaptation of signaling pathway +relationship: part_of GO:0000765 ! response to pheromone regulating pheromone-induced unidirectional conjugation + +[Term] +id: GO:0000767 +name: cell morphogenesis involved in conjugation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0000746 ! conjugation + +[Term] +id: GO:0000768 +name: syncytium formation by plasma membrane fusion +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] +synonym: "cell fusion" BROAD [] +is_a: GO:0006949 ! syncytium formation +is_a: GO:0140253 ! cell-cell fusion + +[Term] +id: GO:0000769 +name: syncytium formation by mitosis without cytokinesis +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb] +synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah] +is_a: GO:0006949 ! syncytium formation + +[Term] +id: GO:0000770 +name: peptide pheromone export +namespace: biological_process +alt_id: GO:0007325 +def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] +synonym: "a-factor export" NARROW [] +is_a: GO:0009914 ! hormone transport +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0000771 +name: agglutination involved in conjugation +namespace: biological_process +def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms +is_a: GO:0098610 ! adhesion between unicellular organisms +relationship: part_of GO:0000746 ! conjugation + +[Term] +id: GO:0000772 +name: mating pheromone activity +namespace: molecular_function +def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] +is_a: GO:0005186 ! pheromone activity + +[Term] +id: GO:0000773 +name: phosphatidyl-N-methylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] +synonym: "methyltransferase II" RELATED [EC:2.1.1.71] +synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71] +synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71] +synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] +synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" RELATED [EC:2.1.1.71] +synonym: "phospholipid methyltransferase activity" RELATED [EC:2.1.1.71] +synonym: "PLMT" EXACT [] +synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.71] +xref: EC:2.1.1.71 +xref: MetaCyc:2.1.1.71-RXN +xref: RHEA:32735 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0000774 +name: adenyl-nucleotide exchange factor activity +namespace: molecular_function +def: "Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] +xref: Reactome:R-HSA-5252079 "HSP110s exchange ATP for ADP on HSP70s:ADP" +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0060590 ! ATPase regulator activity + +[Term] +id: GO:0000775 +name: chromosome, centromeric region +namespace: cellular_component +alt_id: GO:0097521 +def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] +comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. +synonym: "centromere" RELATED [] +synonym: "centromere complex" EXACT [] +synonym: "chromosome, centric region" EXACT [] +synonym: "chromosome, pericentric region" RELATED [] +xref: SO:0000577 +is_a: GO:0098687 ! chromosomal region + +[Term] +id: GO:0000776 +name: kinetochore +namespace: cellular_component +alt_id: GO:0000777 +alt_id: GO:0000778 +alt_id: GO:0005699 +def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] +comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. +subset: goslim_pir +synonym: "condensed chromosome kinetochore" EXACT [] +synonym: "condensed nuclear chromosome kinetochore" EXACT [] +xref: Wikipedia:Kinetochore +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0099080 ! supramolecular complex +relationship: part_of GO:0000779 ! condensed chromosome, centromeric region + +[Term] +id: GO:0000779 +name: condensed chromosome, centromeric region +namespace: cellular_component +alt_id: GO:0000780 +def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] +comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "condensed chromosome, centric region" EXACT [] +synonym: "condensed chromosome, centromere" RELATED [] +synonym: "condensed chromosome, pericentric region" RELATED [] +synonym: "condensed nuclear chromosome, centromeric region" NARROW [] +is_a: GO:0000775 ! chromosome, centromeric region +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0000781 +name: chromosome, telomeric region +namespace: cellular_component +alt_id: GO:0000784 +def: "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres)." [GOC:elh] +comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. +synonym: "nuclear chromosome, telomere" NARROW [] +synonym: "nuclear chromosome, telomeric region" NARROW [] +synonym: "telomere" RELATED [] +xref: SO:0000624 +is_a: GO:0098687 ! chromosomal region + +[Term] +id: GO:0000782 +name: telomere cap complex +namespace: cellular_component +def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] +comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. +subset: goslim_pir +is_a: GO:0032993 ! protein-DNA complex +relationship: part_of GO:0140445 ! chromosome, telomeric repeat region + +[Term] +id: GO:0000783 +name: nuclear telomere cap complex +namespace: cellular_component +def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] +comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. +is_a: GO:0000782 ! telomere cap complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0000785 +name: chromatin +namespace: cellular_component +alt_id: GO:0000789 +alt_id: GO:0000790 +alt_id: GO:0005717 +def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +synonym: "chromosome scaffold" RELATED [] +synonym: "cytoplasmic chromatin" NARROW [] +synonym: "nuclear chromatin" NARROW [] +xref: NIF_Subcellular:sao1615953555 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0000786 +name: nucleosome +namespace: cellular_component +alt_id: GO:0000787 +alt_id: GO:0000788 +alt_id: GO:0005718 +def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] +subset: goslim_pir +synonym: "cytoplasmic nucleosome" NARROW [] +synonym: "nuclear nucleosome" NARROW [] +xref: Wikipedia:Nucleosome +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0044815 ! DNA packaging complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0000791 +name: euchromatin +namespace: cellular_component +alt_id: GO:0005719 +alt_id: GO:0035327 +def: "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation." [PMID:32017156] +synonym: "nuclear euchromatin" RELATED [] +synonym: "transcriptionally active chromatin" EXACT [] +xref: NIF_Subcellular:sao445485807 +xref: Wikipedia:Euchromatin +is_a: GO:0000785 ! chromatin + +[Term] +id: GO:0000792 +name: heterochromatin +namespace: cellular_component +alt_id: GO:0005720 +alt_id: GO:0035328 +def: "A compact and highly condensed form of chromatin that is refractory to transcription." [PMID:32017156] +synonym: "nuclear heterochromatin" NARROW [] +synonym: "transcriptionally inactive chromatin" EXACT [] +synonym: "transcriptionally silent chromatin" EXACT [] +xref: NIF_Subcellular:sao581845896 +xref: Wikipedia:Heterochromatin +is_a: GO:0000785 ! chromatin + +[Term] +id: GO:0000793 +name: condensed chromosome +namespace: cellular_component +def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] +comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. +synonym: "cytoplasmic mitotic chromosome" RELATED [] +synonym: "metaphase chromosome" RELATED [] +synonym: "mitotic chromosome" RELATED [] +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0000794 +name: condensed nuclear chromosome +namespace: cellular_component +def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] +comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. +synonym: "meiotic chromosome" RELATED [] +synonym: "nuclear mitotic chromosome" RELATED [] +is_a: GO:0000228 ! nuclear chromosome +is_a: GO:0000793 ! condensed chromosome + +[Term] +id: GO:0000795 +name: synaptonemal complex +namespace: cellular_component +alt_id: GO:0005716 +def: "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh] +xref: Wikipedia:Synaptonemal_complex +is_a: GO:0099086 ! synaptonemal structure + +[Term] +id: GO:0000796 +name: condensin complex +namespace: cellular_component +alt_id: GO:0000797 +alt_id: GO:0000799 +alt_id: GO:0005676 +alt_id: GO:0008620 +alt_id: GO:0008621 +alt_id: GO:0061814 +def: "A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis." [GOC:elh, PMID:17268547, PMID:21795393] +subset: goslim_pir +synonym: "13S condensin complex" NARROW [] +synonym: "8S condensin complex" NARROW [] +synonym: "condensin core heterodimer" NARROW [] +synonym: "condensin I complex" NARROW [] +synonym: "nuclear condensin complex" NARROW [] +synonym: "SMC complex" RELATED [] +synonym: "Smc2-Smc4 complex" NARROW [] +is_a: GO:0044815 ! DNA packaging complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0000798 +name: nuclear cohesin complex +namespace: cellular_component +def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] +comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. +is_a: GO:0008278 ! cohesin complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0000800 +name: lateral element +namespace: cellular_component +def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] +comment: In species that have a synaptonemal complex, the lateral elements are part of this complex. S.pombe is an example of a species that lacks a (canonical) synaptonemal complex, but still has lateral elements. +synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000801 +name: central element +namespace: cellular_component +def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000802 +name: transverse filament +namespace: cellular_component +def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000795 ! synaptonemal complex + +[Term] +id: GO:0000803 +name: sex chromosome +namespace: cellular_component +def: "A chromosome involved in sex determination." [GOC:elh] +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0000804 +name: W chromosome +namespace: cellular_component +def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] +xref: Wikipedia:ZW_sex-determination_system +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000805 +name: X chromosome +namespace: cellular_component +def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system] +xref: Wikipedia:X_chromosome +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000806 +name: Y chromosome +namespace: cellular_component +def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, GOC:mr, ISBN:0582227089, PMID:20622855, Wikipedia:XY_sex-determination_system] +xref: Wikipedia:Y_chromosome +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000807 +name: Z chromosome +namespace: cellular_component +def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] +xref: Wikipedia:ZW_sex-determination_system +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0000808 +name: origin recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] +subset: goslim_pir +synonym: "ORC" EXACT [] +synonym: "origin of replication recognition complex" EXACT [] +xref: Wikipedia:Origin_recognition_complex +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0000809 +name: cytoplasmic origin of replication recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] +synonym: "cytoplasmic ORC" EXACT [] +synonym: "prokaryotic ORC" RELATED [] +is_a: GO:0000808 ! origin recognition complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0000810 +name: diacylglycerol diphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [GOC:kad, PMID:8567632, PMID:9452443] +synonym: "DGPP phosphatase activity" EXACT [] +synonym: "DGPP phosphohydrolase activity" EXACT [] +synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT [] +xref: EC:3.1.3.81 +xref: MetaCyc:RXN-11277 +xref: RHEA:27449 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0000811 +name: GINS complex +namespace: cellular_component +def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] +synonym: "Go, Ichi, Ni and San complex" EXACT [] +is_a: GO:0031261 ! DNA replication preinitiation complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0000812 +name: Swr1 complex +namespace: cellular_component +def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820] +synonym: "SWR-C" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex +is_a: GO:0097346 ! INO80-type complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0000813 +name: ESCRT I complex +namespace: cellular_component +def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] +synonym: "endosomal sorting complex required for transport" BROAD [] +is_a: GO:0036452 ! ESCRT complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000814 +name: ESCRT II complex +namespace: cellular_component +def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] +synonym: "endosomal sorting complex required for transport" BROAD [] +is_a: GO:0036452 ! ESCRT complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000815 +name: ESCRT III complex +namespace: cellular_component +def: "A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission)." [PMID:17556548, PMID:22361144, PMID:28242692, PMID:31132588, PMID:32243490, PMID:34449766] +synonym: "endosomal sorting complex required for transport" BROAD [] +is_a: GO:0036452 ! ESCRT complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0000817 +name: COMA complex +namespace: cellular_component +def: "A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p." [GOC:se, PMID:14633972] +synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0000818 +name: nuclear MIS12/MIND complex +namespace: cellular_component +def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] +synonym: "MIND complex" EXACT [] +synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] +is_a: GO:0000444 ! MIS12/MIND type complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0000819 +name: sister chromatid segregation +namespace: biological_process +def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] +is_a: GO:0051276 ! chromosome organization +is_a: GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0000820 +name: regulation of glutamine family amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] +synonym: "regulation of glutamine family amino acid metabolism" EXACT [] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0000821 +name: regulation of arginine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] +synonym: "regulation of arginine metabolism" EXACT [] +is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process +relationship: regulates GO:0006525 ! arginine metabolic process + +[Term] +id: GO:0000822 +name: inositol hexakisphosphate binding +namespace: molecular_function +def: "Binding to inositol hexakisphosphate." [GOC:go_curators] +synonym: "InsP6 binding" EXACT [] +synonym: "IP6 binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0000823 +name: inositol-1,4,5-trisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] +synonym: "inositol polyphosphate multikinase activity" BROAD [] +synonym: "inositol trisphosphate 6-kinase activity" BROAD [] +synonym: "IpmK" BROAD [] +xref: EC:2.7.1.151 +xref: KEGG_REACTION:R05800 +xref: MetaCyc:2.7.1.151-RXN +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0000824 +name: inositol tetrakisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] +synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] +synonym: "EC:2.7.1.151" BROAD [] +synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] +synonym: "inositol polyphosphate multikinase activity" BROAD [] +synonym: "IpmK" BROAD [] +xref: Reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" +xref: RHEA:11856 +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0000825 +name: inositol tetrakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] +synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] +synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] +xref: MetaCyc:RXN-7184 +xref: Reactome:R-HSA-1855206 "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0000826 +name: obsolete inositol pyrophosphate synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326] +comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them. +synonym: "inositol diphosphate synthase activity" EXACT [] +synonym: "inositol pyrophosphate synthase activity" EXACT [] +is_obsolete: true +consider: GO:0052746 + +[Term] +id: GO:0000827 +name: inositol-1,3,4,5,6-pentakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242] +xref: EC:2.7.4.21 +xref: Reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus" +xref: Reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0000828 +name: inositol hexakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, GOC:vw, PMID:16429326] +xref: Reactome:R-HSA-1855207 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus" +xref: Reactome:R-HSA-1855216 "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol" +xref: Reactome:R-HSA-1855227 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0000829 +name: inositol heptakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326] +xref: Reactome:R-HSA-1855157 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus" +xref: Reactome:R-HSA-1855182 "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol" +xref: Reactome:R-HSA-1855194 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0000830 +name: inositol hexakisphosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0000831 +name: inositol hexakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0000832 +name: inositol hexakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN, RHEA:12793] +synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] +xref: EC:2.7.4.21 +xref: KEGG_REACTION:R09087 +xref: MetaCyc:2.7.1.152-RXN +xref: RHEA:12793 +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0000833 +name: inositol heptakisphosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] +synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] +synonym: "IP7 4-kinase activity" EXACT [] +is_a: GO:0000829 ! inositol heptakisphosphate kinase activity + +[Term] +id: GO:0000834 +name: inositol heptakisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] +is_a: GO:0000829 ! inositol heptakisphosphate kinase activity + +[Term] +id: GO:0000835 +name: ER ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex found in the ER." [GOC:elh] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0000836 +name: Hrd1p ubiquitin ligase complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78)." [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652] +synonym: "HRD1 ubiquitin ligase complex" RELATED [GOC:bf] +is_a: GO:0000835 ! ER ubiquitin ligase complex + +[Term] +id: GO:0000837 +name: Doa10p ubiquitin ligase complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] +synonym: "Ssm4p ubiquitin ligase complex" EXACT [] +is_a: GO:0000835 ! ER ubiquitin ligase complex + +[Term] +id: GO:0000838 +name: Hrd1p ubiquitin ligase ERAD-M complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] +is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex + +[Term] +id: GO:0000839 +name: Hrd1p ubiquitin ligase ERAD-L complex +namespace: cellular_component +def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] +is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex + +[Term] +id: GO:0000900 +name: translation repressor activity, mRNA regulatory element binding +namespace: molecular_function +def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370] +synonym: "translation repressor activity, nucleic acid binding" BROAD [] +is_a: GO:0030371 ! translation repressor activity +is_a: GO:0090079 ! translation regulator activity, nucleic acid binding + +[Term] +id: GO:0000901 +name: translation repressor activity, non-nucleic acid binding +namespace: molecular_function +def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] +is_a: GO:0030371 ! translation repressor activity +is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding + +[Term] +id: GO:0000902 +name: cell morphogenesis +namespace: biological_process +alt_id: GO:0007148 +alt_id: GO:0045790 +alt_id: GO:0045791 +def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "cellular morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0000903 +name: obsolete regulation of cell shape during vegetative growth phase +namespace: biological_process +alt_id: GO:0090061 +def: "OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw] +comment: The reason for obsoletion is that biological phases should be captured as extensions. +synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw] +synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED [] +is_obsolete: true + +[Term] +id: GO:0000904 +name: cell morphogenesis involved in differentiation +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] +is_a: GO:0000902 ! cell morphogenesis +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0000905 +name: sporocarp development involved in asexual reproduction +namespace: biological_process +def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] +synonym: "conidium development" NARROW [] +synonym: "fruiting body formation involved in asexual reproduction" BROAD [] +synonym: "haploid fruiting" RELATED [] +synonym: "homokaryotic fruiting" RELATED [] +synonym: "imperfect stage fruiting body development" NARROW [] +synonym: "monokaryotic fruiting" RELATED [] +is_a: GO:0030584 ! sporocarp development +relationship: part_of GO:0019954 ! asexual reproduction + +[Term] +id: GO:0000906 +name: 6,7-dimethyl-8-ribityllumazine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [PMID:7559556] +synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] +xref: EC:2.5.1.78 +xref: MetaCyc:LUMAZINESYN-RXN +xref: RHEA:26152 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0000907 +name: sulfonate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [GOC:clt, PMID:10482536] +synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] +synonym: "sulphonate dioxygenase activity" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0000908 +name: taurine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15909] +synonym: "2-aminoethanesulfonate dioxygenase activity" RELATED [EC:1.14.11.17] +synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" RELATED [EC:1.14.11.17] +synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" RELATED [EC:1.14.11.17] +xref: EC:1.14.11.17 +xref: KEGG_REACTION:R05320 +xref: MetaCyc:RXN0-299 +xref: RHEA:15909 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0000909 +name: sporocarp development involved in sexual reproduction +namespace: biological_process +def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] +synonym: "ascus development" NARROW [] +synonym: "fruiting body development involved in sexual reproduction" BROAD [] +synonym: "fruiting body formation involved in sexual reproduction" BROAD [] +synonym: "perfect stage fruiting body development" NARROW [] +is_a: GO:0030584 ! sporocarp development +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0000910 +name: cytokinesis +namespace: biological_process +alt_id: GO:0007104 +alt_id: GO:0016288 +alt_id: GO:0033205 +def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. +subset: gocheck_do_not_manually_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_generic +subset: goslim_yeast +synonym: "cell cycle cytokinesis" EXACT [] +synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] +xref: Wikipedia:Cytokinesis +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051301 ! cell division + +[Term] +id: GO:0000911 +name: cytokinesis by cell plate formation +namespace: biological_process +def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] +is_a: GO:0000910 ! cytokinesis + +[Term] +id: GO:0000912 +name: assembly of actomyosin apparatus involved in cytokinesis +namespace: biological_process +def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle] +synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] +synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] +synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0000913 +name: preprophase band assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] +synonym: "preprophase band formation" RELATED [GOC:mah] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000914 +name: phragmoplast assembly +namespace: biological_process +def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] +synonym: "phragmoplast formation" RELATED [GOC:dph] +is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000915 +name: actomyosin contractile ring assembly +namespace: biological_process +alt_id: GO:0045573 +def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] +synonym: "constriction ring assembly" NARROW [] +synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT [] +synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] +synonym: "cytokinesis, actomyosin ring formation" RELATED [] +synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] +is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis +is_a: GO:0044837 ! actomyosin contractile ring organization + +[Term] +id: GO:0000916 +name: actomyosin contractile ring contraction +namespace: biological_process +def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] +synonym: "actomyosin contractile ring constriction" EXACT [GOC:vw] +synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "cytokinesis, actomyosin ring contraction" EXACT [] +synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] +is_a: GO:0036213 ! contractile ring contraction +relationship: part_of GO:0044837 ! actomyosin contractile ring organization + +[Term] +id: GO:0000917 +name: division septum assembly +namespace: biological_process +alt_id: GO:0071937 +alt_id: GO:1902411 +def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle] +synonym: "division septum assembly involved in cell cycle cytokinesis" NARROW [] +synonym: "division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "division septum formation" EXACT [GOC:mah] +synonym: "division septum formation involved in cell cycle cytokinesis" NARROW [] +synonym: "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "formation of division septum" EXACT [] +synonym: "formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "mitotic division septum assembly" NARROW [] +synonym: "septation" BROAD [] +synonym: "septin assembly and septum biosynthesis" RELATED [] +synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "septin assembly and septum formation" RELATED [] +synonym: "septin assembly and septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] +is_a: GO:0090529 ! cell septum assembly + +[Term] +id: GO:0000918 +name: division septum site selection +namespace: biological_process +def: "The process of marking the site where a division septum will form." [GOC:clt] +synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] +synonym: "selection of site for barrier cell septum formation" EXACT [] +synonym: "selection of site for division septum formation" EXACT [] +synonym: "septin assembly and septum biosynthesis" BROAD [] +synonym: "septin assembly and septum formation" BROAD [] +synonym: "septum positioning" EXACT [] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0000917 ! division septum assembly + +[Term] +id: GO:0000919 +name: cell plate assembly +namespace: biological_process +def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] +synonym: "cell plate formation" RELATED [GOC:mah] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0000911 ! cytokinesis by cell plate formation + +[Term] +id: GO:0000920 +name: septum digestion after cytokinesis +namespace: biological_process +alt_id: GO:1902409 +alt_id: GO:2000695 +def: "The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:vw] +comment: This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process. +synonym: "cell separation after cytokinesis" RELATED [] +synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb] +synonym: "cytokinetic cell separation" RELATED [] +synonym: "daughter cell separation" RELATED [] +synonym: "mitotic cytokinetic cell separation" BROAD [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0051301 ! cell division + +[Term] +id: GO:0000921 +name: septin ring assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] +synonym: "septin assembly and septum biosynthesis" BROAD [] +synonym: "septin assembly and septum formation" BROAD [] +is_a: GO:0031106 ! septin ring organization +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0000922 +name: spindle pole +namespace: cellular_component +alt_id: GO:0030615 +def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0000923 +name: equatorial microtubule organizing center +namespace: cellular_component +def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] +synonym: "EMTOC" EXACT [] +synonym: "equatorial microtubule organising centre" EXACT [] +is_a: GO:0005815 ! microtubule organizing center +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0000930 +name: gamma-tubulin complex +namespace: cellular_component +def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0000931 +name: gamma-tubulin large complex +namespace: cellular_component +alt_id: GO:0000924 +alt_id: GO:0000925 +alt_id: GO:0000926 +alt_id: GO:0000929 +alt_id: GO:0008274 +alt_id: GO:0055031 +alt_id: GO:0055032 +alt_id: GO:0055033 +alt_id: GO:0061494 +def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075, PMID:17021256] +synonym: "gamma-tubulin large complex, centrosomal" NARROW [] +synonym: "gamma-tubulin large complex, eMTOC" NARROW [] +synonym: "gamma-tubulin large complex, equatorial microtubule organizing center" NARROW [] +synonym: "gamma-tubulin large complex, equatorial microtubule organizing centre" NARROW [] +synonym: "gamma-tubulin large complex, iMTOC" NARROW [] +synonym: "gamma-tubulin large complex, interphase microtubule organizing center" NARROW [] +synonym: "gamma-tubulin large complex, interphase microtubule organizing centre" NARROW [] +synonym: "gamma-tubulin large complex, mitotic spindle pole body" NARROW [] +synonym: "gamma-tubulin large complex, spindle pole body" NARROW [] +synonym: "gamma-tubulin ring complex" NARROW [] +synonym: "gamma-tubulin ring complex, centrosomal" NARROW [] +is_a: GO:0000930 ! gamma-tubulin complex + +[Term] +id: GO:0000932 +name: P-body +namespace: cellular_component +def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] +synonym: "cytoplasmic foci" RELATED [] +synonym: "cytoplasmic mRNA processing body" EXACT [] +synonym: "P body" EXACT [] +xref: Wikipedia:P_body +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0000933 +name: adventitious septum +namespace: cellular_component +def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000934 +name: porous cell septum +namespace: cellular_component +def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] +synonym: "porous septum" BROAD [] +is_a: GO:0030428 ! cell septum + +[Term] +id: GO:0000935 +name: division septum +namespace: cellular_component +alt_id: GO:0043187 +def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw] +synonym: "cell septum surface" RELATED [] +synonym: "complete septum" EXACT [] +synonym: "divison septum" EXACT [] +synonym: "septum surface" BROAD [] +is_a: GO:0030428 ! cell septum +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0000936 +name: primary cell septum +namespace: cellular_component +def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] +synonym: "primary septum" BROAD [] +is_a: GO:0000935 ! division septum + +[Term] +id: GO:0000937 +name: dolipore septum +namespace: cellular_component +def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] +is_a: GO:0000934 ! porous cell septum + +[Term] +id: GO:0000938 +name: GARP complex +namespace: cellular_component +def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] +synonym: "Golgi associated retrograde protein complex" EXACT [] +synonym: "VFT tethering complex" EXACT [] +synonym: "Vps fifty three tethering complex" EXACT [] +is_a: GO:0099023 ! vesicle tethering complex +relationship: part_of GO:0005794 ! Golgi apparatus +relationship: part_of GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0000939 +name: inner kinetochore +namespace: cellular_component +alt_id: GO:0000941 +def: "The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] +synonym: "condensed chromosome inner kinetochore" EXACT [] +synonym: "condensed nuclear chromosome inner kinetochore" EXACT [] +synonym: "inner centromere core complex" RELATED [] +synonym: "inner kinetochore of condensed chromosome" EXACT [] +synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [] +synonym: "inner kinetochore plate" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0000940 +name: outer kinetochore +namespace: cellular_component +alt_id: GO:0000942 +def: "The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] +synonym: "condensed chromosome outer kinetochore" EXACT [] +synonym: "condensed nuclear chromosome outer kinetochore" EXACT [] +synonym: "outer kinetochore of condensed chromosome" EXACT [] +synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [] +synonym: "outer kinetochore plate" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0000943 +name: retrotransposon nucleocapsid +namespace: cellular_component +def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] +synonym: "Virus-like particle" EXACT [] +synonym: "VLP" EXACT [] +xref: Wikipedia:Virus-like_particle +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0000947 +name: amino acid catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0000948 +name: amino acid catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0000949 +name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0000950 +name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009083 ! branched-chain amino acid catabolic process + +[Term] +id: GO:0000951 +name: methionine catabolic process to 3-methylthiopropanol +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway +is_a: GO:0009087 ! methionine catabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0000952 +name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0009074 ! aromatic amino acid family catabolic process + +[Term] +id: GO:0000953 +name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0009083 ! branched-chain amino acid catabolic process + +[Term] +id: GO:0000954 +name: methionine catabolic process to 3-methylthiopropanoate +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] +is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0009087 ! methionine catabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0000955 +name: amino acid catabolic process via Ehrlich pathway +namespace: biological_process +def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] +is_a: GO:0009063 ! cellular amino acid catabolic process + +[Term] +id: GO:0000956 +name: nuclear-transcribed mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] +synonym: "nuclear mRNA breakdown" EXACT [] +synonym: "nuclear mRNA catabolism" EXACT [] +synonym: "nuclear mRNA degradation" EXACT [] +is_a: GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0000957 +name: mitochondrial RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0000958 +name: mitochondrial mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000957 ! mitochondrial RNA catabolic process +is_a: GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0000959 +name: mitochondrial RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0000960 +name: regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000961 +name: negative regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process +is_a: GO:1902369 ! negative regulation of RNA catabolic process +relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000962 +name: positive regulation of mitochondrial RNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] +is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process + +[Term] +id: GO:0000963 +name: mitochondrial RNA processing +namespace: biological_process +def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006396 ! RNA processing +is_a: GO:0140053 ! mitochondrial gene expression + +[Term] +id: GO:0000964 +name: mitochondrial RNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] +synonym: "mitochondrial RNA 5' end processing" RELATED [] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0000966 ! RNA 5'-end processing + +[Term] +id: GO:0000965 +name: mitochondrial RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] +synonym: "mitochondrial RNA 3' end processing" RELATED [] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0000966 +name: RNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] +synonym: "RNA 5' end processing" EXACT [] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0000967 +name: rRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] +synonym: "rRNA 5' end processing" EXACT [] +is_a: GO:0006364 ! rRNA processing +is_a: GO:0034471 ! ncRNA 5'-end processing + +[Term] +id: GO:0000968 +name: tRNA exon ligation +namespace: biological_process +def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc] +is_a: GO:0000378 ! RNA exon ligation +relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation + +[Term] +id: GO:0000969 +name: tRNA exon ligation utilizing ATP as source of linkage phosphate +namespace: biological_process +def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] +is_a: GO:0000968 ! tRNA exon ligation + +[Term] +id: GO:0000970 +name: tRNA exon ligation utilizing GTP as source of linkage phosphate +namespace: biological_process +def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] +is_a: GO:0000968 ! tRNA exon ligation + +[Term] +id: GO:0000971 +name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate +namespace: biological_process +def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] +is_a: GO:0000968 ! tRNA exon ligation + +[Term] +id: GO:0000972 +name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery +namespace: biological_process +def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0000973 +name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery +namespace: biological_process +def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] +is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery + +[Term] +id: GO:0000974 +name: Prp19 complex +namespace: cellular_component +def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] +synonym: "nineteen complex" NARROW [] +synonym: "NTC" RELATED [] +synonym: "Prp19/CDC5 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0000976 +name: transcription cis-regulatory region binding +namespace: molecular_function +alt_id: GO:0000975 +alt_id: GO:0000984 +alt_id: GO:0001017 +alt_id: GO:0044212 +def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] +comment: Note that this term is meant to also capture non-specific binding to regulatory regions. Also, to minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. +synonym: "bacterial-type RNA polymerase regulatory region DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding" NARROW [] +synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" NARROW [] +synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" NARROW [] +synonym: "regulatory region DNA binding" BROAD [] +synonym: "transcription regulatory region DNA binding" RELATED [] +synonym: "transcription regulatory region sequence-specific DNA binding" EXACT [] +is_a: GO:0001067 ! transcription regulatory region nucleic acid binding +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0000977 +name: RNA polymerase II transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001012 +def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] +comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. +synonym: "RNA polymerase II regulatory region DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0000978 +name: RNA polymerase II cis-regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0000980 +def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." [GOC:txnOH-2018] +comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to cis-regulatory sequences. In bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is usually a synonym for "enhancer". +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED [] +is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding +is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0000979 +name: RNA polymerase II core promoter sequence-specific DNA binding +namespace: molecular_function +def: "Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene." [GOC:pg, GOC:txnOH, PMID:12381658] +is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding +is_a: GO:0001046 ! core promoter sequence-specific DNA binding + +[Term] +id: GO:0000981 +name: DNA-binding transcription factor activity, RNA polymerase II-specific +namespace: molecular_function +alt_id: GO:0000982 +alt_id: GO:0001133 +alt_id: GO:0001200 +alt_id: GO:0001201 +alt_id: GO:0001202 +alt_id: GO:0001203 +alt_id: GO:0003705 +def: "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] +synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, sequence-specific DNA binding" EXACT [] +synonym: "RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding" EXACT [] +synonym: "RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" NARROW [] +synonym: "sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] +synonym: "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity" RELATED [] +synonym: "transcription factor" BROAD [GOC:vw] +synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] +synonym: "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] +synonym: "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0000987 +name: cis-regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0000986 +alt_id: GO:0001150 +alt_id: GO:0001158 +alt_id: GO:0001159 +alt_id: GO:0035326 +def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter." [GOC:txnOH-2018] +synonym: "bacterial-type cis-regulatory region sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase enhancer sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" NARROW [] +synonym: "cis-regulatory region binding" RELATED [] +synonym: "core promoter proximal region DNA binding" NARROW [] +synonym: "core promoter proximal region sequence-specific DNA binding" NARROW [] +synonym: "enhancer binding" RELATED [] +synonym: "enhancer sequence-specific DNA binding" RELATED [] +synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" NARROW [] +synonym: "promoter proximal region sequence-specific DNA binding" NARROW [] +synonym: "proximal promoter sequence-specific DNA binding" NARROW [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0000988 +name: obsolete transcription factor activity, protein binding +namespace: molecular_function +def: "OBSOLETE. Binding to a protein or protein complex, to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "protein binding transcription factor activity" EXACT [] +synonym: "transcription factor activity" BROAD [] +is_obsolete: true +consider: GO:0005515 +consider: GO:0140110 + +[Term] +id: GO:0000989 +name: obsolete transcription factor activity, transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0008134 +consider: GO:0140110 + +[Term] +id: GO:0000990 +name: obsolete transcription factor activity, core RNA polymerase binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "core RNA polymerase binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0043175 +consider: GO:0140110 + +[Term] +id: GO:0000991 +name: obsolete transcription factor activity, core RNA polymerase II binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "core RNA polymerase II binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0000993 +consider: GO:0140110 + +[Term] +id: GO:0000992 +name: RNA polymerase III cis-regulatory region sequence-specific DNA binding +namespace: molecular_function +def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659] +is_a: GO:0000987 ! cis-regulatory region sequence-specific DNA binding +is_a: GO:0001016 ! RNA polymerase III transcription regulatory region sequence-specific DNA binding + +[Term] +id: GO:0000993 +name: RNA polymerase II complex binding +namespace: molecular_function +def: "Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH] +synonym: "RNA polymerase II core binding" EXACT [] +synonym: "RNAP II core binding" EXACT [] +is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0000994 +name: RNA polymerase III core binding +namespace: molecular_function +def: "Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0000995 +name: RNA polymerase III general transcription initiation factor activity +namespace: molecular_function +alt_id: GO:0001034 +def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III." [GOC:txnOH-2018, PMID:12381659, PMID:17977614, PMID:20413673, PMID:27068803, Wikipedia:RNA_polymerase_III] +synonym: "core RNA polymerase III binding transcription factor activity" NARROW [] +synonym: "RNA polymerase III general initiation factor activity" EXACT [] +synonym: "RNA polymerase III transcription factor activity, sequence-specific DNA binding" NARROW [] +synonym: "sequence-specific DNA binding RNA polymerase III transcription factor activity" NARROW [] +synonym: "transcription factor activity, core RNA polymerase III binding" NARROW [] +is_a: GO:0140223 ! general transcription initiation factor activity + +[Term] +id: GO:0001000 +name: bacterial-type RNA polymerase core enzyme binding +namespace: molecular_function +def: "Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH] +comment: Should omega be included here? +synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT [] +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0001001 +name: mitochondrial single-subunit type RNA polymerase binding +namespace: molecular_function +def: "Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182] +is_a: GO:0001050 ! single-subunit type RNA polymerase binding + +[Term] +id: GO:0001002 +name: RNA polymerase III type 1 promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001030 +def: "Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] +synonym: "RNA polymerase III type 1 promoter DNA binding" RELATED [] +is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding +is_a: GO:0080084 ! 5S rDNA binding + +[Term] +id: GO:0001003 +name: RNA polymerase III type 2 promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001031 +def: "Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] +synonym: "RNA polymerase III type 2 promoter DNA binding" RELATED [] +is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001004 +name: obsolete RNA polymerase III transcription regulator recruiting activity +namespace: molecular_function +alt_id: GO:0001005 +alt_id: GO:0001008 +alt_id: GO:0001033 +alt_id: GO:0001038 +alt_id: GO:0001157 +def: "OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB." [GOC:txnOH-2018, PMID:12381659, PMID:23063749, PMID:27911719, Wikipedia:RNA_polymerase_III] +comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. +synonym: "RNA polymerase III assembly factor activity" RELATED [] +synonym: "RNA polymerase III assembly factor activity, TFIIIB recruiting" RELATED [] +synonym: "RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity" NARROW [] +synonym: "RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] +synonym: "RNA polymerase III transcription factor recruiting activity" EXACT [] +synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] +synonym: "RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] +synonym: "RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity" NARROW [] +synonym: "SNAPc-type activity" RELATED [] +synonym: "TFIIIA activity" RELATED [] +synonym: "TFIIIC-type activity" RELATED [] +synonym: "transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting" EXACT [] +synonym: "transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] +synonym: "transcription factor activity, RNA polymerase III type 1 promoter TFIIIB" RELATED [] +synonym: "transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] +synonym: "transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting" NARROW [] +synonym: "type 2 RNA polymerase III promoter recognition" NARROW [] +synonym: "type 3 RNA polymerase III promoter recognition" NARROW [] +is_obsolete: true + +[Term] +id: GO:0001006 +name: RNA polymerase III type 3 promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001032 +def: "Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] +synonym: "RNA polymerase III type 3 promoter DNA binding" RELATED [] +is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001007 +name: obsolete transcription factor activity, RNA polymerase III transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase III transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001010 +name: RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity +namespace: molecular_function +def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH] +synonym: "sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT [] +synonym: "transcription factor activity, sequence-specific DNA binding transcription factor recruiting" EXACT [] +synonym: "transcription factor activity, sequence-specific DNA-binding transcription factor recruiting" RELATED [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0001011 +name: obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting +namespace: molecular_function +def: "OBSOLETE. Binding to a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH] +comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent. +synonym: "sequence-specific DNA binding RNA polymerase recruiting transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0140223 + +[Term] +id: GO:0001014 +name: snoRNA transcription by RNA polymerase III +namespace: biological_process +def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH] +synonym: "snoRNA transcription from a type 2 RNA polymerase III promoter" NARROW [] +is_a: GO:0006383 ! transcription by RNA polymerase III +is_a: GO:0009302 ! sno(s)RNA transcription + +[Term] +id: GO:0001015 +name: snoRNA transcription by RNA polymerase II +namespace: biological_process +def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH] +synonym: "snoRNA transcription from an RNA polymerase II promoter" EXACT [] +is_a: GO:0006366 ! transcription by RNA polymerase II +is_a: GO:0009302 ! sno(s)RNA transcription + +[Term] +id: GO:0001016 +name: RNA polymerase III transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +def: "Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659] +synonym: "RNA polymerase III regulatory region DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001018 +name: mitochondrial promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0000997 +alt_id: GO:0001044 +alt_id: GO:0001045 +alt_id: GO:0070361 +alt_id: GO:0070362 +alt_id: GO:0070363 +alt_id: GO:0070364 +def: "Binding to a DNA region that controls the transcription of the mitochondrial DNA." [GOC:txnOH, GOC:vw, PMID:20056105] +synonym: "HSP coding strand binding" NARROW [PMID:9485316] +synonym: "HSP non-coding strand binding" NARROW [PMID:9485316] +synonym: "HSPas binding" NARROW [PMID:9485316] +synonym: "HSPs binding" NARROW [PMID:9485316] +synonym: "LSP coding strand binding" NARROW [PMID:9485316] +synonym: "LSP non-coding strand binding" NARROW [PMID:9485316] +synonym: "LSPas binding" NARROW [PMID:9485316] +synonym: "LSPs binding" NARROW [PMID:9485316] +synonym: "mitochondrial heavy strand promoter anti-sense binding" NARROW [] +synonym: "mitochondrial heavy strand promoter sense binding" NARROW [] +synonym: "mitochondrial light strand promoter anti-sense binding" NARROW [] +synonym: "mitochondrial light strand promoter sense binding" NARROW [] +synonym: "mitochondrial proximal promoter sequence-specific DNA binding" RELATED [] +synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding" RELATED [] +synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding" RELATED [] +synonym: "mitochondrial RNA polymerase regulatory region DNA binding" RELATED [] +synonym: "mitochondrial RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001019 +name: plastid promoter transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +def: "Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] +comment: plastid promoter regulatory region sequence-specific DNA binding +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001025 +name: RNA polymerase III general transcription initiation factor binding +namespace: molecular_function +def: "Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH] +synonym: "RNA polymerase III transcription factor binding" BROAD [] +is_a: GO:0140296 ! general transcription initiation factor binding + +[Term] +id: GO:0001026 +name: obsolete TFIIIB-type transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH] +comment: This term was obsoleted because it represents a gene product. +synonym: "RNA polymerase III recruiting transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001027 +name: obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] +comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. +synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001028 +name: obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] +comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. +synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001029 +name: obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] +synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001039 +name: RNA polymerase III hybrid type promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001037 +def: "Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] +synonym: "RNA polymerase III hybrid type promoter DNA binding" RELATED [] +is_a: GO:0000992 ! RNA polymerase III cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001040 +name: obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] +comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. +is_obsolete: true + +[Term] +id: GO:0001042 +name: RNA polymerase I core binding +namespace: molecular_function +def: "Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0001046 +name: core promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0000985 +alt_id: GO:0001047 +def: "Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] +synonym: "bacterial-type RNA polymerase core promoter sequence-specific DNA binding" NARROW [] +synonym: "core promoter binding" RELATED [] +synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" NARROW [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001048 +name: RNA polymerase IV core binding +namespace: molecular_function +def: "Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459] +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0001049 +name: RNA polymerase V core binding +namespace: molecular_function +def: "Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459] +is_a: GO:0043175 ! RNA polymerase core enzyme binding + +[Term] +id: GO:0001050 +name: single-subunit type RNA polymerase binding +namespace: molecular_function +def: "Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] +synonym: "SP6-type RNA polymerase binding" EXACT [] +synonym: "T3-type RNA polymerase binding" EXACT [] +synonym: "T3/T7 type RNA polymerase binding" EXACT [] +synonym: "T7-type RNA polymerase binding" EXACT [] +is_a: GO:0070063 ! RNA polymerase binding + +[Term] +id: GO:0001051 +name: plastid single-subunit type RNA polymerase binding +namespace: molecular_function +def: "Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] +is_a: GO:0001050 ! single-subunit type RNA polymerase binding + +[Term] +id: GO:0001052 +name: plastid PEP RNA polymerase core enzyme binding +namespace: molecular_function +def: "Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995] +is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding + +[Term] +id: GO:0001054 +name: RNA polymerase I activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001055 +name: RNA polymerase II activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] +xref: Reactome:R-HSA-6814549 "Pre-snRNA transcript initiation, Integrator binding, LEC binding" +xref: Reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001056 +name: RNA polymerase III activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [] +xref: Reactome:R-HSA-1964482 "RNA polymerase III transcribes microbial dsDNA to dsRNA" +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001057 +name: RNA polymerase IV activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT [] +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001058 +name: RNA polymerase V activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT [] +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001059 +name: transcription by RNA polymerase IV +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459] +synonym: "transcription from RNA pol IV promoter" EXACT [] +synonym: "transcription from RNA polymerase IV promoter" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0001060 +name: transcription by RNA polymerase V +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459] +synonym: "transcription from RNA pol V promoter" EXACT [] +synonym: "transcription from RNA polymerase V promoter" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0001061 +name: obsolete bacterial-type RNA polymerase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +comment: This term was obsoleted because the activity is the same as its parent. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0001062 +name: obsolete plastid PEP-A RNA polymerase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] +comment: This term was obsoleted because the activity is the same as its parent. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0001063 +name: obsolete plastid PEP-B RNA polymerase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] +comment: This term was obsoleted because the activity is the same as its parent. +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0001064 +name: single subunit type RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +synonym: "T3/T7 type RNA polymerase activity" EXACT [] +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0001065 +name: mitochondrial single subunit type RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] +is_a: GO:0001064 ! single subunit type RNA polymerase activity + +[Term] +id: GO:0001066 +name: plastid single subunit type RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] +is_a: GO:0001064 ! single subunit type RNA polymerase activity + +[Term] +id: GO:0001067 +name: transcription regulatory region nucleic acid binding +namespace: molecular_function +def: "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] +synonym: "regulatory region nucleic acid binding" RELATED [] +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0001068 +name: transcription regulatory region RNA binding +namespace: molecular_function +def: "Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon." [GOC:txnOH] +is_a: GO:0001069 ! regulatory region RNA binding + +[Term] +id: GO:0001069 +name: regulatory region RNA binding +namespace: molecular_function +def: "Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] +is_a: GO:0001067 ! transcription regulatory region nucleic acid binding +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0001070 +name: RNA-binding transcription regulator activity +namespace: molecular_function +def: "A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences." [GOC:txnOH-2018, PMID:1756726] +synonym: "RNA binding transcription factor activity" RELATED [] +synonym: "RNA binding transcription regulator activity" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0001072 +name: transcription antitermination factor activity, RNA binding +namespace: molecular_function +def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211] +synonym: "RNA binding transcription antitermination factor activity" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0001073 +name: transcription antitermination factor activity, DNA binding +namespace: molecular_function +def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211] +synonym: "DNA binding transcription antitermination factor activity" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0001074 +name: obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly +namespace: molecular_function +def: "OBSOLETE. Binding to a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT [] +synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001076 +name: obsolete transcription factor activity, RNA polymerase II transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "RNA polymerase II transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0061629 +consider: GO:0140110 + +[Term] +id: GO:0001079 +name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] +synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0090293 ! nitrogen catabolite regulation of transcription + +[Term] +id: GO:0001080 +name: nitrogen catabolite activation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] +synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] +is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter +is_a: GO:0090294 ! nitrogen catabolite activation of transcription + +[Term] +id: GO:0001081 +name: nitrogen catabolite repression of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] +synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] +is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter +is_a: GO:0090295 ! nitrogen catabolite repression of transcription + +[Term] +id: GO:0001082 +name: obsolete transcription factor activity, RNA polymerase I transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase I transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001083 +name: obsolete transcription factor activity, RNA polymerase II basal transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase II basal transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001084 +name: obsolete transcription factor activity, TFIID-class binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIID-class binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001094 + +[Term] +id: GO:0001086 +name: obsolete transcription factor activity, TFIIA-class binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIIA-class binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001092 + +[Term] +id: GO:0001087 +name: obsolete transcription factor activity, TFIIB-class binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIIB-class binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001093 + +[Term] +id: GO:0001088 +name: obsolete transcription factor activity, TFIIE-class binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIIE-class binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001095 + +[Term] +id: GO:0001089 +name: obsolete transcription factor activity, TFIIF-class transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIIF-class binding transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001096 + +[Term] +id: GO:0001090 +name: obsolete transcription factor activity, TFIIH-class binding +namespace: molecular_function +def: "OBSOLETE. Binding to a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "TFIIH-class binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001091 +name: RNA polymerase II general transcription initiation factor binding +namespace: molecular_function +def: "Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] +synonym: "RNA polymerase II basal transcription factor binding" EXACT [] +is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding +is_a: GO:0140296 ! general transcription initiation factor binding + +[Term] +id: GO:0001092 +name: TFIIA-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] +synonym: "TFIIA-class transcription factor binding" EXACT [] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001093 +name: TFIIB-class transcription factor binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding + +[Term] +id: GO:0001094 +name: TFIID-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] +synonym: "TFIID-class transcription factor binding" EXACT [] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001095 +name: TFIIE-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] +synonym: "TFIIE-class transcription factor binding" EXACT [] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001096 +name: TFIIF-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] +synonym: "TFIIF-class transcription factor binding" EXACT [] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001097 +name: TFIIH-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] +synonym: "TFIIH-class transcription factor binding" EXACT [] +is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001098 +name: basal transcription machinery binding +namespace: molecular_function +def: "Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] +comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001099 +name: basal RNA polymerase II transcription machinery binding +namespace: molecular_function +def: "Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] +comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. +synonym: "basal RNAP II transcription machinery binding" EXACT [] +is_a: GO:0001098 ! basal transcription machinery binding + +[Term] +id: GO:0001100 +name: negative regulation of exit from mitosis +namespace: biological_process +def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] +synonym: "down regulation of exit from mitosis" EXACT [] +synonym: "down-regulation of exit from mitosis" EXACT [] +synonym: "downregulation of exit from mitosis" EXACT [] +synonym: "inhibition of exit from mitosis" NARROW [] +is_a: GO:0007096 ! regulation of exit from mitosis +is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition +relationship: negatively_regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0001101 +name: response to acid chemical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn] +comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. +subset: gocheck_do_not_manually_annotate +synonym: "response to acid" BROAD [] +synonym: "response to acid anion" RELATED [] +synonym: "response to oxoanion" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0001108 +name: bacterial-type RNA polymerase holo enzyme binding +namespace: molecular_function +def: "Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH] +synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT [] +is_a: GO:0001098 ! basal transcription machinery binding + +[Term] +id: GO:0001109 +name: promoter clearance during DNA-templated transcription +namespace: biological_process +alt_id: GO:0001122 +def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161] +synonym: "promoter clearance during DNA-dependent transcription" EXACT [GOC:txnOH] +synonym: "promoter clearance from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "promoter escape" BROAD [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0001110 +name: promoter clearance from RNA polymerase III promoter +namespace: biological_process +def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH] +is_a: GO:0001109 ! promoter clearance during DNA-templated transcription +relationship: part_of GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0001111 +name: promoter clearance from RNA polymerase II promoter +namespace: biological_process +def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] +synonym: "promoter escape from RNA polymerase II promoter" EXACT [] +is_a: GO:0001109 ! promoter clearance during DNA-templated transcription +relationship: part_of GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0001112 +name: DNA-templated transcription open complex formation +namespace: biological_process +alt_id: GO:0001127 +def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] +synonym: "DNA-dependent transcriptional open complex formation" EXACT [GOC:txnOH] +synonym: "DNA-templated transcriptional open complex formation" EXACT [] +synonym: "promoter melting" BROAD [] +synonym: "transcription open complex formation at bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcriptional open complex formation at bacterial-type RNA polymerase promoter" NARROW [] +is_a: GO:0001120 ! protein-DNA complex remodeling +relationship: part_of GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:0001113 +name: transcription open complex formation at RNA polymerase II promoter +namespace: biological_process +def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] +synonym: "RNA polymerase II promoter melting" EXACT [] +synonym: "transcriptional open complex formation at RNA polymerase II promoter" EXACT [] +is_a: GO:0001112 ! DNA-templated transcription open complex formation +relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0001114 +name: protein-DNA-RNA complex +namespace: cellular_component +def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0001115 +name: protein-DNA-RNA complex subunit organization +namespace: biological_process +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH] +synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0001116 +name: protein-DNA-RNA complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex." [GOC:txnOH] +is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0001117 +name: protein-DNA-RNA complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH] +is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0001118 +name: transcription ternary complex disassembly +namespace: biological_process +def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH] +synonym: "transcription protein-DNA-RNA complex disassembly" EXACT [] +is_a: GO:0001117 ! protein-DNA-RNA complex disassembly +relationship: part_of GO:0006353 ! DNA-templated transcription, termination + +[Term] +id: GO:0001119 +name: protein-DNA-RNA complex remodeling +namespace: biological_process +def: "The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] +is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization +is_a: GO:0034367 ! protein-containing complex remodeling + +[Term] +id: GO:0001120 +name: protein-DNA complex remodeling +namespace: biological_process +def: "The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] +is_a: GO:0034367 ! protein-containing complex remodeling +is_a: GO:0071824 ! protein-DNA complex subunit organization + +[Term] +id: GO:0001128 +name: obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867] +comment: This term was obsoleted because it represented a mix of function and process and is not annotated consistently +synonym: "RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001129 +name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly +namespace: molecular_function +def: "OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW [] +synonym: "TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001132 +name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding +namespace: molecular_function +def: "OBSOLETE. Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW [] +synonym: "TBP-class protein binding RNA polymerase II transcription factor activity" EXACT [] +synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW [] +is_obsolete: true + +[Term] +id: GO:0001134 +name: obsolete transcription regulator recruiting activity +namespace: molecular_function +def: "OBSOLETE. The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] +comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. +synonym: "transcription factor activity, transcription factor recruiting" RELATED [] +synonym: "transcription factor recruiting activity" EXACT [] +synonym: "transcription factor recruiting transcription factor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003712 + +[Term] +id: GO:0001135 +name: obsolete RNA polymerase II transcription regulator recruiting activity +namespace: molecular_function +alt_id: GO:0001136 +alt_id: GO:0001137 +alt_id: GO:0001138 +def: "OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] +comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. +synonym: "RNA polymerase II transcription factor recruiting activity" EXACT [] +synonym: "RNA polymerase II transcription factor recruiting transcription factor activity" EXACT [] +synonym: "TFIIE-class transcription factor recruiting transcription factor activity" NARROW [] +synonym: "TFIIF-class transcription factor recruiting transcription factor activity" NARROW [] +synonym: "TFIIH-class transcription factor recruiting transcription factor activity" NARROW [] +synonym: "transcription factor activity, RNA polymerase II transcription factor recruiting" RELATED [] +synonym: "transcription factor activity, TFIIE-class transcription factor recruiting" NARROW [] +synonym: "transcription factor activity, TFIIF-class transcription factor recruiting" NARROW [] +synonym: "transcription factor activity, TFIIH-class transcription factor recruiting" NARROW [] +is_obsolete: true +replaced_by: GO:0003712 + +[Term] +id: GO:0001139 +name: RNA polymerase II complex recruiting activity +namespace: molecular_function +def: "Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] +synonym: "core RNA polymerase II recruiting transcription factor activity" EXACT [] +synonym: "transcription factor activity, core RNA polymerase II recruiting" RELATED [] +is_a: GO:0000993 ! RNA polymerase II complex binding + +[Term] +id: GO:0001147 +name: transcription termination site sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001145 +alt_id: GO:0001146 +alt_id: GO:0001148 +alt_id: GO:0001160 +def: "Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175] +comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a DNA specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. +synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding" NARROW [] +synonym: "mitochondrial RNA polymerase termination site sequence-specific DNA binding" NARROW [] +synonym: "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding" NARROW [] +synonym: "transcription termination site DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001149 +name: obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding +namespace: molecular_function +def: "OBSOLETE. Binding to a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] +synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001152 +name: obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting +namespace: molecular_function +def: "OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659] +comment: This term was made obsolete in the 2018 Transcription branch revision. This represents the activity of TFIIIA only. +synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity" EXACT [] +synonym: "TFIIIA activity" RELATED [] +synonym: "type 1 RNA polymerase III promoter recognition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001153 +name: obsolete transcription factor activity, RNA polymerase III transcription factor recruiting +namespace: molecular_function +def: "OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH] +comment: This term was made obsolete in the 2018 Transcription branch revision. This term was redundant with other terms. +synonym: "RNA polymerase III transcription factor recruiting transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001154 +name: TFIIIB-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] +synonym: "TFIIIB-class transcription factor binding" EXACT [] +is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding + +[Term] +id: GO:0001155 +name: TFIIIA-class transcription factor binding +namespace: molecular_function +def: "Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters." [GOC:txnOH, PMID:12381659] +is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding + +[Term] +id: GO:0001156 +name: TFIIIC-class transcription factor complex binding +namespace: molecular_function +def: "Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] +synonym: "TFIIIC-class transcription factor binding" EXACT [] +is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding + +[Term] +id: GO:0001161 +name: intronic transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0044213 +def: "Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] +comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. +synonym: "intronic transcription regulatory region DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001162 +name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +def: "Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] +comment: To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. +is_a: GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding +is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001163 +name: RNA polymerase I transcription regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001013 +def: "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] +synonym: "RNA polymerase I regulatory region DNA binding" RELATED [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0001164 +name: RNA polymerase I core promoter sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001187 +def: "Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] +synonym: "RNA polymerase I CORE element sequence-specific DNA binding" EXACT [] +synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity" RELATED [] +synonym: "transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting" RELATED [] +is_a: GO:0001046 ! core promoter sequence-specific DNA binding +is_a: GO:0001163 ! RNA polymerase I transcription regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001165 +name: RNA polymerase I cis-regulatory region sequence-specific DNA binding +namespace: molecular_function +alt_id: GO:0001166 +def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element)." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] +synonym: "RNA polymerase I enhancer sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase I upstream control element sequence-specific DNA binding" RELATED [] +synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED [] +is_a: GO:0001163 ! RNA polymerase I transcription regulatory region sequence-specific DNA binding + +[Term] +id: GO:0001167 +name: obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding +namespace: molecular_function +def: "OBSOLETE. Binding to a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "sequence-specific DNA binding RNA polymerase I transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001168 +name: obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding +namespace: molecular_function +def: "OBSOLETE. Binding to a upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001169 +name: obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding +namespace: molecular_function +def: "OBSOLETE. Binding to CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001170 +name: obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding +namespace: molecular_function +def: "OBSOLETE. Binding to a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] +comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. +synonym: "RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001171 +name: reverse transcription +namespace: biological_process +def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252] +xref: Wikipedia:Reverse_transcription +is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process + +[Term] +id: GO:0001172 +name: transcription, RNA-templated +namespace: biological_process +def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH] +synonym: "transcription, RNA-dependent" EXACT [GOC:txnOH] +is_a: GO:0097659 ! nucleic acid-templated transcription + +[Term] +id: GO:0001173 +name: DNA-templated transcriptional start site selection +namespace: biological_process +alt_id: GO:0001176 +def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] +synonym: "DNA-dependent transcriptional start site selection" EXACT [GOC:txnOH] +synonym: "transcriptional start site selection at bacterial-type RNA polymerase promoter" NARROW [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:0001174 +name: transcriptional start site selection at RNA polymerase II promoter +namespace: biological_process +def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] +is_a: GO:0001173 ! DNA-templated transcriptional start site selection +relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0001175 +name: transcriptional start site selection at RNA polymerase III promoter +namespace: biological_process +def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] +is_a: GO:0001173 ! DNA-templated transcriptional start site selection +relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter + +[Term] +id: GO:0001177 +name: regulation of transcription open complex formation at RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH] +synonym: "regulation of transcriptional open complex formation at RNA polymerase II promoter" EXACT [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0001113 ! transcription open complex formation at RNA polymerase II promoter + +[Term] +id: GO:0001178 +name: regulation of transcriptional start site selection at RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] +synonym: "regulation of transcription start site selection at RNA polymerase II promoter" EXACT [] +is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter +relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter + +[Term] +id: GO:0001179 +name: RNA polymerase I general transcription initiation factor binding +namespace: molecular_function +def: "Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH] +synonym: "RNA polymerase I transcription factor binding" BROAD [] +is_a: GO:0140296 ! general transcription initiation factor binding + +[Term] +id: GO:0001181 +name: RNA polymerase I general transcription initiation factor activity +namespace: molecular_function +def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs." [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304] +synonym: "core RNA polymerase I binding transcription factor activity" BROAD [] +synonym: "general RNA polymerase I transcription factor activity" EXACT [] +synonym: "RNA polymerase I transcription general initiation factor activity" EXACT [] +synonym: "transcription factor activity, core RNA polymerase I binding" BROAD [] +is_a: GO:0140223 ! general transcription initiation factor activity + +[Term] +id: GO:0001182 +name: promoter clearance from RNA polymerase I promoter +namespace: biological_process +def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] +is_a: GO:0001109 ! promoter clearance during DNA-templated transcription +relationship: part_of GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0001183 +name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH] +is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter +relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I + +[Term] +id: GO:0001184 +name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript +namespace: biological_process +def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] +is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter +relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I + +[Term] +id: GO:0001186 +name: obsolete RNA polymerase I transcription regulator recruiting activity +namespace: molecular_function +def: "OBSOLETE. The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:12381659, PMID:14969726, PMID:8057832] +comment: The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. +synonym: "RNA polymerase I transcription factor recruiting activity" EXACT [] +synonym: "RNA polymerase I transcription factor recruiting transcription factor activity" EXACT [] +synonym: "transcription factor activity, RNA polymerase I transcription factor recruiting" RELATED [] +is_obsolete: true +replaced_by: GO:0003712 + +[Term] +id: GO:0001188 +name: RNA polymerase I preinitiation complex assembly +namespace: biological_process +alt_id: GO:0001189 +def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] +synonym: "RNA polymerase I transcriptional preinitiation complex assembly" EXACT [] +synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript" NARROW [] +synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript" NARROW [] +is_a: GO:0070897 ! transcription preinitiation complex assembly +relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter + +[Term] +id: GO:0001190 +name: obsolete transcriptional activator activity, RNA polymerase II transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "RNA polymerase II transcription factor binding transcription activator activity" EXACT [] +synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription" EXACT [] +is_obsolete: true +consider: GO:0001228 +consider: GO:0061629 + +[Term] +id: GO:0001191 +name: obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT [] +synonym: "RNA polymerase II transcription factor binding transcription repressor activity" EXACT [] +synonym: "RNA polymerase II transcription repressor activity" BROAD [] +is_obsolete: true +consider: GO:0001227 +consider: GO:0061629 + +[Term] +id: GO:0001192 +name: maintenance of transcriptional fidelity during DNA-templated transcription elongation +namespace: biological_process +alt_id: GO:0001194 +def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH] +synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation" EXACT [GOC:txnOH] +synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter" EXACT [GOC:txnOH] +synonym: "maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter" NARROW [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006354 ! DNA-templated transcription, elongation + +[Term] +id: GO:0001193 +name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter +namespace: biological_process +def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246] +synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter" EXACT [GOC:txnOH] +is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation +relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:0001195 +name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter +namespace: biological_process +def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH] +synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter" EXACT [GOC:txnOH] +is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation +relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter + +[Term] +id: GO:0001196 +name: regulation of mating-type specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated + +[Term] +id: GO:0001197 +name: positive regulation of mating-type specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] +synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] +synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] +synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] +synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] +synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] +is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter +is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated + +[Term] +id: GO:0001198 +name: negative regulation of mating-type specific transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] +synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT [] +synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT [] +synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT [] +synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW [] +is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter +is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated + +[Term] +id: GO:0001207 +name: obsolete histone displacement +namespace: biological_process +def: "OBSOLETE. The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0140713 + +[Term] +id: GO:0001208 +name: obsolete histone H2A-H2B dimer displacement +namespace: biological_process +def: "OBSOLETE. The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0140713 + +[Term] +id: GO:0001216 +name: DNA-binding transcription activator activity +namespace: molecular_function +alt_id: GO:0001140 +alt_id: GO:0001215 +def: "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets." [GOC:txnOH-2018] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED [] +synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] +synonym: "transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" RELATED [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0001217 +name: DNA-binding transcription repressor activity +namespace: molecular_function +alt_id: GO:0001141 +alt_id: GO:0001218 +alt_id: GO:0001219 +alt_id: GO:0001220 +def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets." [GOC:txnOH-2018] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "bacterial-type DNA binding transcription repressor activity" NARROW [] +synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding" NARROW [] +synonym: "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] +synonym: "transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0001221 +name: transcription coregulator binding +namespace: molecular_function +alt_id: GO:0001224 +def: "Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] +synonym: "RNA polymerase II transcription cofactor binding" RELATED [] +synonym: "RNA polymerase II transcription coregulator binding" RELATED [] +synonym: "transcription cofactor binding" RELATED [] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0001222 +name: transcription corepressor binding +namespace: molecular_function +alt_id: GO:0001226 +def: "Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] +synonym: "RNA polymerase II transcription corepressor binding" RELATED [] +is_a: GO:0001221 ! transcription coregulator binding + +[Term] +id: GO:0001223 +name: transcription coactivator binding +namespace: molecular_function +alt_id: GO:0001225 +def: "Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] +synonym: "RNA polymerase II transcription coactivator binding" RELATED [] +is_a: GO:0001221 ! transcription coregulator binding + +[Term] +id: GO:0001227 +name: DNA-binding transcription repressor activity, RNA polymerase II-specific +namespace: molecular_function +alt_id: GO:0001078 +alt_id: GO:0001206 +alt_id: GO:0001210 +alt_id: GO:0001214 +def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II." [GOC:txnOH-2018] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] +synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT [] +synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] +synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] +synonym: "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] +synonym: "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] +is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific +is_a: GO:0001217 ! DNA-binding transcription repressor activity + +[Term] +id: GO:0001228 +name: DNA-binding transcription activator activity, RNA polymerase II-specific +namespace: molecular_function +alt_id: GO:0001077 +alt_id: GO:0001205 +alt_id: GO:0001209 +alt_id: GO:0001211 +alt_id: GO:0001212 +alt_id: GO:0001213 +def: "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II." [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] +synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT [] +synonym: "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] +synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding" NARROW [] +synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] +synonym: "transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] +synonym: "transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding" NARROW [] +synonym: "transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] +synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] +is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific +is_a: GO:0001216 ! DNA-binding transcription activator activity + +[Term] +id: GO:0001300 +name: obsolete chronological cell aging +namespace: biological_process +def: "OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +synonym: "chronological cell ageing" EXACT [] +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0001301 +name: progressive alteration of chromatin involved in cell aging +namespace: biological_process +def: "Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, GOC:vw, PMID:12044938] +synonym: "age-dependent accumulation of genetic damage" RELATED [] +synonym: "progressive alteration of chromatin during cell ageing" EXACT [] +synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006325 ! chromatin organization +relationship: part_of GO:0007569 ! cell aging + +[Term] +id: GO:0001302 +name: obsolete replicative cell aging +namespace: biological_process +def: "OBSOLETE. The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "replicative cell ageing" EXACT [] +is_obsolete: true +consider: GO:0090399 + +[Term] +id: GO:0001303 +name: obsolete nucleolar fragmentation involved in replicative aging +namespace: biological_process +def: "OBSOLETE. A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "nucleolar fragmentation during replicative ageing" RELATED [] +synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001304 +name: obsolete progressive alteration of chromatin involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] +synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001305 +name: obsolete progressive alteration of chromatin involved in chronological cell aging +namespace: biological_process +def: "OBSOLETE. A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] +synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0001306 +name: age-dependent response to oxidative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] +is_a: GO:0006979 ! response to oxidative stress +relationship: part_of GO:0007571 ! age-dependent general metabolic decline + +[Term] +id: GO:0001307 +name: obsolete extrachromosomal circular DNA accumulation involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] +synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001308 +name: obsolete negative regulation of chromatin silencing involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] +synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001309 +name: obsolete age-dependent telomere shortening +namespace: biological_process +def: "OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] +comment: This term was made obsolete because it represents a phenotype. +synonym: "age-dependent telomere shortening" EXACT [] +is_obsolete: true +consider: GO:1903824 + +[Term] +id: GO:0001310 +name: obsolete extrachromosomal rDNA circle accumulation involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] +synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] +synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001311 +name: obsolete formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED [] +synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] +synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] +synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001312 +name: obsolete replication of extrachromosomal rDNA circles involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] +synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] +synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001313 +name: obsolete formation of extrachromosomal circular DNA involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT [] +synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] +synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001314 +name: obsolete replication of extrachromosomal circular DNA involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] +synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001315 +name: age-dependent response to reactive oxygen species +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] +synonym: "age-dependent response to active oxygen species" EXACT [] +synonym: "age-dependent response to AOS" EXACT [] +synonym: "age-dependent response to reactive oxidative species" EXACT [] +synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] +synonym: "age-dependent response to ROI" EXACT [] +synonym: "age-dependent response to ROS" EXACT [] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0001306 ! age-dependent response to oxidative stress + +[Term] +id: GO:0001316 +name: obsolete age-dependent response to reactive oxygen species involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] +synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] +synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] +synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] +synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] +synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] +synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] +synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] +is_obsolete: true + +[Term] +id: GO:0001317 +name: obsolete accumulation of oxidatively modified proteins involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] +synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001318 +name: obsolete formation of oxidatively modified proteins involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] +synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001319 +name: obsolete inheritance of oxidatively modified proteins involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] +synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001320 +name: obsolete age-dependent response to reactive oxygen species involved in chronological cell aging +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] +synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] +synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED [] +synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] +synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] +synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] +synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] +synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0001321 +name: obsolete age-dependent general metabolic decline involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] +synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001322 +name: obsolete age-dependent response to oxidative stress involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] +synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0001323 +name: obsolete age-dependent general metabolic decline involved in chronological cell aging +namespace: biological_process +def: "OBSOLETE. A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] +synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0001324 +name: obsolete age-dependent response to oxidative stress involved in chronological cell aging +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] +synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0001325 +name: formation of extrachromosomal circular DNA +namespace: biological_process +def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] +synonym: "assembly of extrachromosomal circular DNA" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0001326 +name: replication of extrachromosomal circular DNA +namespace: biological_process +def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0001400 +name: mating projection base +namespace: cellular_component +def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] +synonym: "base of shmoo tip" NARROW [] +synonym: "conjugation tube base" NARROW [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0001401 +name: SAM complex +namespace: cellular_component +def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] +comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. +synonym: "mitochondrial sorting and assembly machinery complex" EXACT [] +synonym: "TOB complex" EXACT [] +is_a: GO:0005742 ! mitochondrial outer membrane translocase complex + +[Term] +id: GO:0001402 +name: signal transduction involved in filamentous growth +namespace: biological_process +def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] +synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] +synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0030447 ! filamentous growth + +[Term] +id: GO:0001403 +name: invasive growth in response to glucose limitation +namespace: biological_process +def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] +comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. +subset: goslim_yeast +synonym: "colony morphology" RELATED [] +is_a: GO:0036267 ! invasive filamentous growth + +[Term] +id: GO:0001404 +name: obsolete invasive growth +namespace: biological_process +def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "invasive growth" EXACT [] +synonym: "tissue invasion" EXACT [] +is_obsolete: true +consider: GO:0044409 + +[Term] +id: GO:0001405 +name: PAM complex, Tim23 associated import motor +namespace: cellular_component +def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix." [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855] +synonym: "mitochondrial import motor" EXACT [] +synonym: "PAM complex" EXACT [] +synonym: "pre-sequence translocase-associated import motor" EXACT [] +synonym: "presequence translocase-associated import motor" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005744 ! TIM23 mitochondrial import inner membrane translocase complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0001406 +name: glycerophosphodiester transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity + +[Term] +id: GO:0001407 +name: glycerophosphodiester transmembrane transport +namespace: biological_process +def: "The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0001408 +name: guanine nucleotide transport +namespace: biological_process +def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc] +is_a: GO:0015865 ! purine nucleotide transport + +[Term] +id: GO:0001409 +name: guanine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other." [GOC:mcc] +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity + +[Term] +id: GO:0001410 +name: chlamydospore formation +namespace: biological_process +alt_id: GO:0055027 +def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] +synonym: "chlamydospore development" EXACT [] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0001411 +name: hyphal tip +namespace: cellular_component +def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] +subset: goslim_candida +is_a: GO:0030427 ! site of polarized growth +is_a: GO:0051286 ! cell tip + +[Term] +id: GO:0001501 +name: skeletal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb] +synonym: "skeletal development" EXACT [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0001502 +name: cartilage condensation +namespace: biological_process +def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] +is_a: GO:0098743 ! cell aggregation +relationship: part_of GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0001503 +name: ossification +namespace: biological_process +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] +comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. +synonym: "bone biosynthesis" EXACT [] +synonym: "bone formation" EXACT [] +synonym: "osteogenesis" EXACT [] +xref: Wikipedia:Ossification +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0001504 +name: neurotransmitter uptake +namespace: biological_process +def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +subset: goslim_synapse +synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "neurotransmitter import into glial cell" NARROW [] +synonym: "neurotransmitter import into neuron" NARROW [] +synonym: "neurotransmitter recycling" BROAD [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0001505 +name: regulation of neurotransmitter levels +namespace: biological_process +def: "Any process that modulates levels of neurotransmitter." [GOC:jl] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0001506 +name: obsolete neurotransmitter biosynthetic process and storage +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] +comment: This term was made obsolete because it is an amalgamation of its two children. +synonym: "neurotransmitter anabolism and storage" EXACT [] +synonym: "neurotransmitter biosynthetic process and storage" EXACT [] +synonym: "neurotransmitter formation and storage" EXACT [] +synonym: "neurotransmitter synthesis and storage" EXACT [] +is_obsolete: true +consider: GO:0042136 +consider: GO:0042137 + +[Term] +id: GO:0001507 +name: acetylcholine catabolic process in synaptic cleft +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] +synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] +synonym: "acetylcholine degradation in synaptic cleft" EXACT [] +is_a: GO:0006581 ! acetylcholine catabolic process +relationship: part_of GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0001508 +name: action potential +namespace: biological_process +def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] +comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0001509 +name: obsolete legumain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] +synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] +synonym: "citvac" RELATED [EC:3.4.22.34] +synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] +synonym: "legumain activity" EXACT [] +synonym: "phaseolin activity" RELATED [EC:3.4.22.34] +synonym: "proteinase B" RELATED [EC:3.4.22.34] +synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] +synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0001510 +name: RNA methylation +namespace: biological_process +def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd, PMID:21823225] +is_a: GO:0009451 ! RNA modification +is_a: GO:0043414 ! macromolecule methylation + +[Term] +id: GO:0001511 +name: obsolete fibrillin +namespace: molecular_function +def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "fibrillin" EXACT [] +is_obsolete: true +consider: GO:0001527 +consider: GO:0005509 + +[Term] +id: GO:0001512 +name: dihydronicotinamide riboside quinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [RHEA:12364] +comment: Formerly EC:1.10.99.2. +synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" RELATED [EC:1.10.5.1] +synonym: "NQO(2) activity" RELATED [EC:1.10.5.1] +synonym: "NQO2" RELATED [EC:1.10.5.1] +synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.5.1] +synonym: "QR2 activity" RELATED [EC:1.10.5.1] +synonym: "quinone reductase 2 activity" RELATED [EC:1.10.5.1] +synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] +xref: EC:1.10.5.1 +xref: MetaCyc:1.10.99.2-RXN +xref: Reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones" +xref: RHEA:12364 +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0001514 +name: selenocysteine incorporation +namespace: biological_process +def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] +xref: RESID:AA0022 +is_a: GO:0006451 ! translational readthrough + +[Term] +id: GO:0001515 +name: opioid peptide activity +namespace: molecular_function +def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] +subset: goslim_chembl +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0001516 +name: prostaglandin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] +synonym: "prostaglandin anabolism" EXACT [] +synonym: "prostaglandin biosynthesis" EXACT [] +synonym: "prostaglandin formation" EXACT [] +synonym: "prostaglandin synthesis" EXACT [] +is_a: GO:0006693 ! prostaglandin metabolic process +is_a: GO:0046457 ! prostanoid biosynthetic process + +[Term] +id: GO:0001517 +name: N-acetylglucosamine 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] +subset: goslim_chembl +synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] +xref: Reactome:R-HSA-2046222 "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG" +xref: Reactome:R-HSA-3656269 "Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG" +xref: Reactome:R-HSA-6786012 "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0001518 +name: voltage-gated sodium channel complex +namespace: cellular_component +def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] +synonym: "voltage gated sodium channel complex" EXACT [] +synonym: "voltage-dependent sodium channel complex" EXACT [] +synonym: "voltage-sensitive sodium channel complex" EXACT [] +xref: NIF_Subcellular:sao785001660 +is_a: GO:0034706 ! sodium channel complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0001519 +name: peptide amidation +namespace: biological_process +def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] +is_a: GO:0031179 ! peptide modification + +[Term] +id: GO:0001520 +name: outer dense fiber +namespace: cellular_component +def: "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins." [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759] +synonym: "outer dense fibre" EXACT [] +is_a: GO:0099513 ! polymeric cytoskeletal fiber +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0001522 +name: pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] +synonym: "pseudouridylation" EXACT [] +xref: Wikipedia:Pseudouridine +xref: Wikipedia:Pseudouridylation +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0001523 +name: retinoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732] +synonym: "retinoid metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process + +[Term] +id: GO:0001524 +name: obsolete globin +namespace: molecular_function +def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "globin" EXACT [] +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0001525 +name: angiogenesis +namespace: biological_process +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] +synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] +xref: Wikipedia:Angiogenesis +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0001526 +name: obsolete proteoglycan sulfate transfer +namespace: biological_process +def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] +comment: This term was made obsolete because it represents a group of molecular functions. +synonym: "proteoglycan sulfate transfer" EXACT [] +synonym: "proteoglycan sulphate transfer" EXACT [] +is_obsolete: true +consider: GO:0006029 +consider: GO:0006790 +consider: GO:0050698 + +[Term] +id: GO:0001527 +name: microfibril +namespace: cellular_component +def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [PMID:27026396] +synonym: "extended fibrils" EXACT [] +synonym: "fibrillin" RELATED [] +is_a: GO:0099512 ! supramolecular fiber +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:0001528 +name: obsolete elastin +namespace: molecular_function +def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "elastin" EXACT [] +is_obsolete: true +replaced_by: GO:0030023 + +[Term] +id: GO:0001529 +name: obsolete elastin +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "elastin" EXACT [] +is_obsolete: true +replaced_by: GO:0030023 + +[Term] +id: GO:0001530 +name: lipopolysaccharide binding +namespace: molecular_function +def: "Binding to a lipopolysaccharide." [PMID:11079463] +synonym: "endotoxin binding" BROAD [] +synonym: "LPS binding" EXACT [] +is_a: GO:0008289 ! lipid binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0001531 +name: interleukin-21 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-21 receptor." [GOC:ai] +synonym: "IL-21" NARROW [] +synonym: "interleukin-21 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0001532 +name: interleukin-21 receptor activity +namespace: molecular_function +def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-21 receptor activity" EXACT [GOC:mah] +synonym: "IL-21R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0001533 +name: cornified envelope +namespace: cellular_component +def: "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] +is_a: GO:0005886 ! plasma membrane + +[Term] +id: GO:0001534 +name: radial spoke +namespace: cellular_component +def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] +subset: goslim_pir +xref: Wikipedia:Radial_spoke +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0001535 +name: radial spoke head +namespace: cellular_component +def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:cilia, GOC:hjd, GOC:krc] +synonym: "radial spokehead" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0001534 ! radial spoke + +[Term] +id: GO:0001536 +name: radial spoke stalk +namespace: cellular_component +def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0001534 ! radial spoke + +[Term] +id: GO:0001537 +name: N-acetylgalactosamine 4-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] +synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] +xref: Reactome:R-HSA-2022063 "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS" +xref: Reactome:R-HSA-3636919 "Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS" +xref: Reactome:R-HSA-6786034 "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0001539 +name: cilium or flagellum-dependent cell motility +namespace: biological_process +def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] +comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "ciliary or bacterial-type flagellar motility" RELATED [] +synonym: "ciliary/flagellar motility" EXACT [] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0001540 +name: amyloid-beta binding +namespace: molecular_function +def: "Binding to an amyloid-beta peptide/protein." [GOC:hjd] +subset: goslim_chembl +synonym: "beta-amyloid binding" EXACT [] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0001541 +name: ovarian follicle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +synonym: "follicular phase" RELATED [] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001542 +name: ovulation from ovarian follicle +namespace: biological_process +def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0030728 ! ovulation +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001543 +name: ovarian follicle rupture +namespace: biological_process +def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001542 ! ovulation from ovarian follicle + +[Term] +id: GO:0001544 +name: initiation of primordial ovarian follicle growth +namespace: biological_process +def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001545 +name: primary ovarian follicle growth +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0040007 ! growth +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001546 +name: preantral ovarian follicle growth +namespace: biological_process +def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0040007 ! growth +relationship: part_of GO:0001541 ! ovarian follicle development +relationship: part_of GO:0048162 ! multi-layer follicle stage + +[Term] +id: GO:0001547 +name: antral ovarian follicle growth +namespace: biological_process +def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001548 +name: follicular fluid formation in ovarian follicle antrum +namespace: biological_process +def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] +synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001547 ! antral ovarian follicle growth + +[Term] +id: GO:0001549 +name: cumulus cell differentiation +namespace: biological_process +def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [PMID:30010832] +synonym: "ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0001547 ! antral ovarian follicle growth +relationship: part_of GO:0048165 ! fused antrum stage + +[Term] +id: GO:0001550 +name: ovarian cumulus expansion +namespace: biological_process +def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [PMID:30010832] +synonym: "ovarian cumulus growth" RELATED [] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0040007 ! growth +relationship: part_of GO:0001547 ! antral ovarian follicle growth +relationship: part_of GO:0048165 ! fused antrum stage + +[Term] +id: GO:0001551 +name: ovarian follicle endowment +namespace: biological_process +def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [PMID:30010832] +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0001552 +name: ovarian follicle atresia +namespace: biological_process +def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, PMID:18638134] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001553 +name: luteinization +namespace: biological_process +def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +synonym: "luteal phase" RELATED [] +xref: Wikipedia:Luteal_phase +xref: Wikipedia:Luteinization +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001554 +name: luteolysis +namespace: biological_process +def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [PMID:10617764] +xref: Wikipedia:Luteolysis +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0001555 +name: oocyte growth +namespace: biological_process +def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [https://www.ncbi.nlm.nih.gov/books/NBK279054/] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0001556 +name: oocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, https://www.ncbi.nlm.nih.gov/books/NBK279054/] +xref: Wikipedia:Oocyte_maturation +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0001557 +name: obsolete metabolic process resulting in cell growth +namespace: biological_process +def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] +comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. +synonym: "metabolic process resulting in cell growth" EXACT [] +is_obsolete: true +consider: GO:0008152 +consider: GO:0016049 + +[Term] +id: GO:0001558 +name: regulation of cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0016049 ! cell growth + +[Term] +id: GO:0001559 +name: obsolete regulation of cell growth by detection of nuclear:cytoplasmic ratio +namespace: biological_process +def: "OBSOLETE. Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] +synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] +synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] +synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001560 +name: regulation of cell growth by extracellular stimulus +namespace: biological_process +def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] +synonym: "interpretation of external signals that regulate cell growth" EXACT [] +synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] +synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] +synonym: "regulation of growth by exogenous signal" EXACT [] +synonym: "regulation of growth by exogenous stimuli" EXACT [] +synonym: "regulation of growth by exogenous stimulus" EXACT [] +synonym: "regulation of growth by external signal" EXACT [] +synonym: "regulation of growth by external stimuli" EXACT [] +synonym: "regulation of growth by external stimulus" EXACT [] +is_a: GO:0001558 ! regulation of cell growth +relationship: part_of GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0001561 +name: fatty acid alpha-oxidation +namespace: biological_process +def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [PMID:10198260] +xref: MetaCyc:PWY-2501 +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0001562 +name: response to protozoan +namespace: biological_process +alt_id: GO:0042833 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] +synonym: "resistance to pathogenic protozoa" RELATED [] +synonym: "response to protozoa" EXACT [] +synonym: "response to protozoon" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0001563 +name: detection of protozoan +namespace: biological_process +def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] +synonym: "detection of protozoa" EXACT [] +synonym: "detection of protozoon" EXACT [] +synonym: "perception of protozoa" RELATED [] +is_a: GO:0001562 ! response to protozoan +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0001564 +name: obsolete resistance to pathogenic protozoa +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "resistance to pathogenic protozoa" EXACT [] +is_obsolete: true +replaced_by: GO:0001562 + +[Term] +id: GO:0001565 +name: phorbol ester receptor activity +namespace: molecular_function +def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0001566 +name: non-kinase phorbol ester receptor activity +namespace: molecular_function +def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570] +is_a: GO:0001565 ! phorbol ester receptor activity + +[Term] +id: GO:0001567 +name: cholesterol 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21104] +synonym: "cholesterol 25-monooxygenase activity" RELATED [EC:1.14.99.38] +synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" RELATED [EC:1.14.99.38] +xref: EC:1.14.99.38 +xref: KEGG_REACTION:R07218 +xref: MetaCyc:1.14.99.38-RXN +xref: RHEA:21104 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0001568 +name: blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001944 ! vasculature development + +[Term] +id: GO:0001569 +name: branching involved in blood vessel morphogenesis +namespace: biological_process +def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] +synonym: "patterning of blood vessels" BROAD [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0001525 ! angiogenesis + +[Term] +id: GO:0001570 +name: vasculogenesis +namespace: biological_process +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] +synonym: "vascular morphogenesis" EXACT [] +xref: Wikipedia:Vasculogenesis +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0001571 +name: non-tyrosine kinase fibroblast growth factor receptor activity +namespace: molecular_function +def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238] +synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] +synonym: "non-tyrosine kinase FGFR activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0001572 +name: lactosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501] +synonym: "lactosylceramide anabolism" EXACT [] +synonym: "lactosylceramide biosynthesis" EXACT [] +synonym: "lactosylceramide formation" EXACT [] +synonym: "lactosylceramide synthesis" EXACT [] +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0046478 ! lactosylceramide metabolic process +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:0001573 +name: ganglioside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] +synonym: "ganglioside metabolism" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0001574 +name: ganglioside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] +synonym: "ganglioside anabolism" EXACT [] +synonym: "ganglioside biosynthesis" EXACT [] +synonym: "ganglioside formation" EXACT [] +synonym: "ganglioside synthesis" EXACT [] +is_a: GO:0001573 ! ganglioside metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:0001575 +name: globoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732] +synonym: "globoside metabolism" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0001576 +name: globoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732] +synonym: "globoside anabolism" EXACT [] +synonym: "globoside biosynthesis" EXACT [] +synonym: "globoside formation" EXACT [] +synonym: "globoside synthesis" EXACT [] +is_a: GO:0001575 ! globoside metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process + +[Term] +id: GO:0001577 +name: obsolete galectin +namespace: molecular_function +def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "galectin" EXACT [] +synonym: "S-type lectin" EXACT [] +is_obsolete: true +consider: GO:0007157 +consider: GO:0016936 + +[Term] +id: GO:0001578 +name: microtubule bundle formation +namespace: biological_process +def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] +synonym: "microtubule bundling" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0001579 +name: medium-chain fatty acid transport +namespace: biological_process +def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0001580 +name: detection of chemical stimulus involved in sensory perception of bitter taste +namespace: biological_process +def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "bitter taste detection" EXACT [] +synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] +synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of bitter taste" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] +synonym: "sensory transduction of bitter taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050913 ! sensory perception of bitter taste + +[Term] +id: GO:0001581 +name: detection of chemical stimulus involved in sensory perception of sour taste +namespace: biological_process +def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] +synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] +synonym: "sensory detection of sour taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] +synonym: "sensory transduction of sour taste" EXACT [] +synonym: "sour taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050915 ! sensory perception of sour taste + +[Term] +id: GO:0001582 +name: detection of chemical stimulus involved in sensory perception of sweet taste +namespace: biological_process +def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] +synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] +synonym: "sensory detection of sweet taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] +synonym: "sensory transduction of sweet taste" EXACT [] +synonym: "sweet taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050916 ! sensory perception of sweet taste + +[Term] +id: GO:0001583 +name: detection of chemical stimulus involved in sensory perception of salty taste +namespace: biological_process +def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] +synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] +synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "salty taste detection" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] +synonym: "sensory detection of salty taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] +synonym: "sensory transduction of salty taste" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050914 ! sensory perception of salty taste + +[Term] +id: GO:0001584 +name: obsolete rhodopsin-like receptor activity +namespace: molecular_function +alt_id: GO:0001620 +def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +synonym: "Class A G protein coupled receptor" EXACT [] +synonym: "Class A G-protein coupled receptor" EXACT [] +synonym: "Class A GPCR" EXACT [] +synonym: "class A orphan receptor activity" EXACT [] +synonym: "rhodopsin-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001586 +name: Gi/o-coupled serotonin receptor activity +namespace: molecular_function +def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247] +synonym: "5-HT1 receptor activity" EXACT [GOC:bf] +synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf] +is_a: GO:0004993 ! G protein-coupled serotonin receptor activity + +[Term] +id: GO:0001587 +name: Gq/11-coupled serotonin receptor activity +namespace: molecular_function +def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043] +synonym: "5-HT2 receptor activity" BROAD [GOC:bf] +synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf] +is_a: GO:0004993 ! G protein-coupled serotonin receptor activity + +[Term] +id: GO:0001588 +name: dopamine neurotransmitter receptor activity, coupled via Gs +namespace: molecular_function +alt_id: GO:0001589 +alt_id: GO:0001590 +def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260] +synonym: "dopamine D1 receptor activity" NARROW [GOC:bf] +synonym: "dopamine D5 receptor activity" NARROW [GOC:bf] +is_a: GO:0004952 ! dopamine neurotransmitter receptor activity + +[Term] +id: GO:0001591 +name: dopamine neurotransmitter receptor activity, coupled via Gi/Go +namespace: molecular_function +alt_id: GO:0001592 +alt_id: GO:0001593 +alt_id: GO:0001670 +def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258] +synonym: "dopamine D2 receptor activity" NARROW [GOC:bf] +synonym: "dopamine D3 receptor activity" NARROW [GOC:bf] +synonym: "dopamine D4 receptor activity" NARROW [GOC:bf] +is_a: GO:0004952 ! dopamine neurotransmitter receptor activity + +[Term] +id: GO:0001594 +name: trace-amine receptor activity +namespace: molecular_function +def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074] +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:0001595 +name: angiotensin receptor activity +namespace: molecular_function +def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0001596 +name: angiotensin type I receptor activity +namespace: molecular_function +def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869] +synonym: "PLC-activating angiotensin receptor activity" EXACT [GOC:bf] +is_a: GO:0001595 ! angiotensin receptor activity + +[Term] +id: GO:0001597 +name: obsolete apelin-like receptor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because the function it represents does not exist. +synonym: "apelin-like receptor" EXACT [] +synonym: "APJ-like receptor" EXACT [] +is_obsolete: true +consider: GO:0031704 + +[Term] +id: GO:0001598 +name: obsolete chemokine receptor-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "chemokine receptor-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001601 +name: peptide YY receptor activity +namespace: molecular_function +def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0004983 ! neuropeptide Y receptor activity + +[Term] +id: GO:0001602 +name: pancreatic polypeptide receptor activity +namespace: molecular_function +def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0004983 ! neuropeptide Y receptor activity + +[Term] +id: GO:0001603 +name: obsolete vasopressin-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] +synonym: "vasopressin-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001604 +name: urotensin II receptor activity +namespace: molecular_function +def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0001605 +name: adrenomedullin receptor activity +namespace: molecular_function +def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] +synonym: "G10D receptor" NARROW [] +is_a: GO:0097642 ! calcitonin family receptor activity + +[Term] +id: GO:0001606 +name: obsolete GPR37/endothelin B-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "GPR37/endothelin B-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001607 +name: neuromedin U receptor activity +namespace: molecular_function +def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] +synonym: "NMUR activity" EXACT [] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0001608 +name: G protein-coupled nucleotide receptor activity +namespace: molecular_function +def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294] +synonym: "G protein coupled nucleotide receptor activity" EXACT [] +synonym: "G-protein coupled nucleotide receptor activity" EXACT [] +synonym: "nucleotide receptor activity, G protein coupled" EXACT [] +synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0001609 +name: G protein-coupled adenosine receptor activity +namespace: molecular_function +alt_id: GO:0001610 +alt_id: GO:0001611 +alt_id: GO:0001612 +alt_id: GO:0001613 +alt_id: GO:0008501 +def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289] +synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] +synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] +synonym: "adenosine nucleotide receptor" BROAD [] +synonym: "adenosine receptor activity, G protein coupled" EXACT [] +synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf] +synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] +synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] +synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] +synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] +synonym: "G protein coupled adenosine receptor activity" EXACT [] +synonym: "G-protein coupled adenosine receptor activity" EXACT [] +synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] +synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] +synonym: "P1 receptor" EXACT [PMID:9755289] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0001614 +name: purinergic nucleotide receptor activity +namespace: molecular_function +alt_id: GO:0035586 +def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +synonym: "P2 receptor" RELATED [PMID:9755289] +synonym: "purinergic receptor activity" RELATED [] +synonym: "purinoceptor" EXACT [PMID:9755289] +synonym: "purinoreceptor" EXACT [PMID:9755289] +is_a: GO:0016502 ! nucleotide receptor activity + +[Term] +id: GO:0001615 +name: obsolete thyrotropin releasing hormone and secretagogue-like receptors activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "thyrotropin releasing hormone and secretagogue-like receptors activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001616 +name: growth hormone secretagogue receptor activity +namespace: molecular_function +def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853] +synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0001617 +name: obsolete growth hormone secretagogue-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "growth hormone secretagogue-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001618 +name: virus receptor activity +namespace: molecular_function +def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] +subset: goslim_chembl +synonym: "viral receptor activity" EXACT [] +is_a: GO:0140272 ! exogenous protein binding + +[Term] +id: GO:0001619 +name: obsolete lysosphingolipid and lysophosphatidic acid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] +synonym: "lysosphingolipid and lysophosphatidic acid receptor activity" EXACT [] +is_obsolete: true +consider: GO:0038036 +consider: GO:0070915 + +[Term] +id: GO:0001621 +name: G protein-coupled ADP receptor activity +namespace: molecular_function +alt_id: GO:0045032 +def: "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:11196645] +synonym: "ADP receptor activity" BROAD [] +synonym: "ADP-activated adenosine receptor activity" RELATED [] +synonym: "ADP-activated nucleotide receptor activity" BROAD [] +synonym: "K101 receptor" NARROW [] +synonym: "platelet ADP receptor activity" NARROW [GOC:mah] +is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity + +[Term] +id: GO:0001626 +name: nociceptin receptor activity +namespace: molecular_function +def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432] +synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf] +synonym: "OFQ receptor activity" EXACT [PR:000012940] +synonym: "ORPH receptor" EXACT [] +synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf] +synonym: "X-opioid receptor activity" RELATED [GOC:bf] +is_a: GO:0004985 ! G protein-coupled opioid receptor activity + +[Term] +id: GO:0001627 +name: obsolete leucine-rich G-protein receptor-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] +synonym: "leucine-rich G-protein receptor-like receptor activity" EXACT [] +synonym: "LGR-like receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001628 +name: obsolete gastropyloric receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the gastropyloric receptor is a type of neuron. +synonym: "gastropyloric receptor activity" EXACT [] +synonym: "GPR receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001629 +name: obsolete G-protein receptor 45-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "G protein receptor 45-like receptor activity" EXACT [] +synonym: "G-protein receptor 45-like receptor activity" EXACT [] +synonym: "GPR45-like receptor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001630 +name: obsolete GP40-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "GP40-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001631 +name: cysteinyl leukotriene receptor activity +namespace: molecular_function +def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] +synonym: "CysLT receptor" EXACT [] +is_a: GO:0004974 ! leukotriene receptor activity + +[Term] +id: GO:0001632 +name: leukotriene B4 receptor activity +namespace: molecular_function +def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732] +synonym: "BLT receptor" NARROW [] +is_a: GO:0004974 ! leukotriene receptor activity + +[Term] +id: GO:0001633 +name: obsolete secretin-like receptor activity +namespace: molecular_function +alt_id: GO:0001638 +def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +synonym: "class B G protein coupled receptor" EXACT [] +synonym: "class B G-protein coupled receptor" EXACT [] +synonym: "class B GPCR" EXACT [] +synonym: "class B orphan receptor activity" EXACT [] +synonym: "secretin-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001634 +name: pituitary adenylate cyclase-activating polypeptide receptor activity +namespace: molecular_function +alt_id: GO:0016522 +def: "A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] +synonym: "PACAP receptor" EXACT [] +synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] +synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] +synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] +synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0001635 +name: calcitonin gene-related peptide receptor activity +namespace: molecular_function +def: "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity." [GOC:mah, PMID:12037140] +synonym: "calcitonin gene-related polypeptide receptor activity" EXACT [] +synonym: "CGRP receptor" EXACT [] +xref: Wikipedia:CALCRL +is_a: GO:0097642 ! calcitonin family receptor activity + +[Term] +id: GO:0001636 +name: obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0001637 +name: G protein-coupled chemoattractant receptor activity +namespace: molecular_function +def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah] +synonym: "G protein chemoattractant receptor activity" EXACT [] +synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf] +synonym: "G-protein coupled chemoattractant receptor activity" EXACT [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0001639 +name: PLC activating G protein-coupled glutamate receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] +synonym: "Group I metabotropic glutamate receptor" RELATED [] +synonym: "group I metabotropic glutamate receptor activity" RELATED [] +synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] +synonym: "PLC activating G-protein coupled glutamate receptor activity" EXACT [] +synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf] +is_a: GO:0098988 ! G protein-coupled glutamate receptor activity + +[Term] +id: GO:0001640 +name: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity +namespace: molecular_function +def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph] +synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf] +synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] +is_a: GO:0098988 ! G protein-coupled glutamate receptor activity + +[Term] +id: GO:0001641 +name: group II metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] +is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity + +[Term] +id: GO:0001642 +name: group III metabotropic glutamate receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] +is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity + +[Term] +id: GO:0001646 +name: cAMP receptor activity +namespace: molecular_function +alt_id: GO:0001644 +def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg] +synonym: "3',5' cAMP receptor activity" EXACT [] +synonym: "3',5'-cAMP receptor activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] +synonym: "class E G protein coupled receptor" BROAD [] +synonym: "class E G-protein coupled receptor" BROAD [] +synonym: "class E GPCR" BROAD [] +synonym: "cyclic AMP receptor activity" EXACT [] +is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity + +[Term] +id: GO:0001647 +name: G protein-coupled cytokinin receptor activity +namespace: molecular_function +def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] +synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf] +synonym: "G protein coupled cytokinin receptor activity" EXACT [] +synonym: "G-protein coupled cytokinin receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0009884 ! cytokinin receptor activity + +[Term] +id: GO:0001648 +name: proteinase activated receptor activity +namespace: molecular_function +def: "A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0001649 +name: osteoblast differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] +synonym: "osteoblast cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001503 ! ossification + +[Term] +id: GO:0001650 +name: fibrillar center +namespace: cellular_component +def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] +synonym: "fibrillar centre" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0001651 +name: dense fibrillar component +namespace: cellular_component +def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] +synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412] +xref: NIF_Subcellular:sao1841764412 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0001652 +name: granular component +namespace: cellular_component +def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] +synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903] +xref: NIF_Subcellular:sao1217793903 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0001653 +name: peptide receptor activity +namespace: molecular_function +def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] +synonym: "endogenous peptide receptor activity" NARROW [] +synonym: "exogenous peptide receptor activity" NARROW [] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0001654 +name: eye development +namespace: biological_process +alt_id: GO:0042460 +def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] +xref: Wikipedia:Eye_development +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0150063 ! visual system development + +[Term] +id: GO:0001655 +name: urogenital system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0001656 +name: metanephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0001657 +name: ureteric bud development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0072164 ! mesonephric tubule development + +[Term] +id: GO:0001658 +name: branching involved in ureteric bud morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] +synonym: "ureteric bud branching" EXACT [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0060675 ! ureteric bud morphogenesis + +[Term] +id: GO:0001659 +name: temperature homeostasis +namespace: biological_process +def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] +synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] +xref: Wikipedia:Thermoregulation +is_a: GO:0048871 ! multicellular organismal homeostasis + +[Term] +id: GO:0001660 +name: fever generation +namespace: biological_process +def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl] +synonym: "pyrexia" BROAD [] +xref: Wikipedia:Fever +is_a: GO:0006953 ! acute-phase response +is_a: GO:0031649 ! heat generation + +[Term] +id: GO:0001661 +name: conditioned taste aversion +namespace: biological_process +def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] +xref: Wikipedia:Conditioned_taste_aversion +xref: Wikipedia:Taste_aversion +is_a: GO:0007631 ! feeding behavior +is_a: GO:0008306 ! associative learning + +[Term] +id: GO:0001662 +name: behavioral fear response +namespace: biological_process +def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] +synonym: "behavioural fear response" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0042596 ! fear response + +[Term] +id: GO:0001664 +name: G protein-coupled receptor binding +namespace: molecular_function +def: "Binding to a G protein-coupled receptor." [GOC:ceb, GOC:dph] +synonym: "G protein coupled receptor binding" EXACT [] +synonym: "G protein coupled receptor ligand" NARROW [] +synonym: "G-protein coupled receptor binding" EXACT [GOC:bf] +synonym: "G-protein-coupled receptor ligand" NARROW [] +xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer" +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0001665 +name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] +synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.3] +synonym: "GalNAc alpha-2,6-sialyltransferase I activity" RELATED [EC:2.4.99.3] +xref: EC:2.4.99.3 +xref: MetaCyc:2.4.99.3-RXN +xref: Reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)" +xref: Reactome:R-HSA-9603991 "ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG" +xref: RHEA:11136 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0001666 +name: response to hypoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] +comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. +synonym: "response to hypoxic stress" EXACT [] +synonym: "response to intermittent hypoxia" NARROW [] +synonym: "response to lowered oxygen tension" EXACT [] +synonym: "response to sustained hypoxia" NARROW [] +is_a: GO:0006950 ! response to stress +is_a: GO:0036293 ! response to decreased oxygen levels + +[Term] +id: GO:0001667 +name: ameboidal-type cell migration +namespace: biological_process +def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] +comment: Note that this term refers to a mode of migration rather than to any particular cell type. +synonym: "ameboid cell migration" EXACT [] +synonym: "amoeboid cell migration" EXACT [] +synonym: "amoeboidal cell migration" EXACT [] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0001669 +name: acrosomal vesicle +namespace: cellular_component +def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] +synonym: "acrosomal granule" EXACT [GOC:sart] +synonym: "acrosome" EXACT [GOC:dph] +xref: Wikipedia:Acrosome +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0001671 +name: ATPase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of an ATP hydrolysis activity." [GOC:ajp] +synonym: "ATPase stimulator activity" EXACT [] +xref: Reactome:R-HSA-5251955 "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm" +xref: Reactome:R-HSA-5251959 "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol" +is_a: GO:0140677 ! molecular function activator activity + +[Term] +id: GO:0001672 +name: regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "regulation of chromatin assembly/disassembly" EXACT [] +is_a: GO:1902275 ! regulation of chromatin organization +relationship: regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0001673 +name: male germ cell nucleus +namespace: cellular_component +alt_id: GO:0043081 +def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] +synonym: "male germ-cell nucleus" EXACT [] +is_a: GO:0043073 ! germ cell nucleus + +[Term] +id: GO:0001674 +name: female germ cell nucleus +namespace: cellular_component +alt_id: GO:0043080 +def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] +synonym: "female germ-cell nucleus" EXACT [] +is_a: GO:0043073 ! germ cell nucleus + +[Term] +id: GO:0001675 +name: acrosome assembly +namespace: biological_process +def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0033363 ! secretory granule organization +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0001676 +name: long-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ajp] +synonym: "long-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0001677 +name: formation of translation initiation ternary complex +namespace: biological_process +def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] +synonym: "translation initiation ternary complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006413 ! translational initiation + +[Term] +id: GO:0001678 +name: cellular glucose homeostasis +namespace: biological_process +def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042593 ! glucose homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0001680 +name: tRNA 3'-terminal CCA addition +namespace: biological_process +def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators] +synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72] +synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.72] +synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.72] +synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" RELATED [EC:2.7.7.72] +synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72] +synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72] +synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72] +synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72] +synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] +synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72] +xref: KEGG_REACTION:R09382 +xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN +is_a: GO:0042780 ! tRNA 3'-end processing + +[Term] +id: GO:0001681 +name: sialate O-acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] +synonym: "N-acetylneuraminate acetyltransferase activity" RELATED [EC:3.1.1.53] +synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" RELATED [EC:3.1.1.53] +synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] +xref: EC:3.1.1.53 +xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN +is_a: GO:0008126 ! acetylesterase activity + +[Term] +id: GO:0001682 +name: tRNA 5'-leader removal +namespace: biological_process +def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] +synonym: "tRNA 5' leader removal" EXACT [] +is_a: GO:0099116 ! tRNA 5'-end processing + +[Term] +id: GO:0001683 +name: obsolete axonemal dynein heavy chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "axonemal dynein heavy chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001684 +name: obsolete axonemal dynein intermediate chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "axonemal dynein intermediate chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001685 +name: obsolete axonemal dynein intermediate light chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "axonemal dynein intermediate light chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001686 +name: obsolete axonemal dynein light chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "axonemal dynein light chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005858 + +[Term] +id: GO:0001687 +name: obsolete cytoplasmic dynein heavy chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "cytoplasmic dynein heavy chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001688 +name: obsolete cytoplasmic dynein intermediate chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "cytoplasmic dynein intermediate chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001689 +name: obsolete cytoplasmic dynein intermediate light chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "cytoplasmic dynein intermediate light chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001690 +name: obsolete cytoplasmic dynein light chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "cytoplasmic dynein light chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005868 + +[Term] +id: GO:0001691 +name: pseudophosphatase activity +namespace: molecular_function +def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] +is_a: GO:0019212 ! phosphatase inhibitor activity + +[Term] +id: GO:0001692 +name: histamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine metabolism" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0052803 ! imidazole-containing compound metabolic process +is_a: GO:0097164 ! ammonium ion metabolic process + +[Term] +id: GO:0001694 +name: histamine biosynthetic process +namespace: biological_process +alt_id: GO:0001693 +def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine anabolism" EXACT [] +synonym: "histamine biosynthesis" EXACT [] +synonym: "histamine formation" EXACT [] +synonym: "histamine synthesis" EXACT [] +is_a: GO:0001692 ! histamine metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0001695 +name: histamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] +synonym: "histamine breakdown" EXACT [] +synonym: "histamine catabolism" EXACT [] +synonym: "histamine degradation" EXACT [] +is_a: GO:0001692 ! histamine metabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:0052805 ! imidazole-containing compound catabolic process + +[Term] +id: GO:0001696 +name: gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] +synonym: "hydrochloric acid secretion" NARROW [] +is_a: GO:0022600 ! digestive system process +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0001697 +name: histamine-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0001698 +name: gastrin-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0001699 +name: acetylcholine-induced gastric acid secretion +namespace: biological_process +def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] +is_a: GO:0001696 ! gastric acid secretion +relationship: part_of GO:1905145 ! cellular response to acetylcholine + +[Term] +id: GO:0001700 +name: embryonic development via the syncytial blastoderm +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0009792 ! embryo development ending in birth or egg hatching + +[Term] +id: GO:0001701 +name: in utero embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0001702 +name: gastrulation with mouth forming second +namespace: biological_process +alt_id: GO:0010003 +alt_id: GO:0048276 +def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] +synonym: "deuterostomic gastrulation" EXACT [GOC:dph] +is_a: GO:0007369 ! gastrulation + +[Term] +id: GO:0001703 +name: gastrulation with mouth forming first +namespace: biological_process +def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] +synonym: "protostomic gastrulation" NARROW [GOC:dph] +is_a: GO:0007369 ! gastrulation + +[Term] +id: GO:0001704 +name: formation of primary germ layer +namespace: biological_process +def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0001705 +name: ectoderm formation +namespace: biological_process +def: "The formation of ectoderm during gastrulation." [GOC:go_curators] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0007398 ! ectoderm development + +[Term] +id: GO:0001706 +name: endoderm formation +namespace: biological_process +def: "The formation of the endoderm during gastrulation." [GOC:go_curators] +synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0007492 ! endoderm development + +[Term] +id: GO:0001707 +name: mesoderm formation +namespace: biological_process +def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] +is_a: GO:0001704 ! formation of primary germ layer +relationship: part_of GO:0048332 ! mesoderm morphogenesis + +[Term] +id: GO:0001708 +name: cell fate specification +namespace: biological_process +def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0001709 +name: cell fate determination +namespace: biological_process +def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] +xref: Wikipedia:Cell_fate_determination +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0001710 +name: mesodermal cell fate commitment +namespace: biological_process +def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "mesoderm cell fate commitment" EXACT [] +is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer +relationship: part_of GO:0048333 ! mesodermal cell differentiation + +[Term] +id: GO:0001711 +name: endodermal cell fate commitment +namespace: biological_process +def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "endoderm cell fate commitment" EXACT [] +is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer +relationship: part_of GO:0035987 ! endodermal cell differentiation + +[Term] +id: GO:0001712 +name: ectodermal cell fate commitment +namespace: biological_process +def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] +synonym: "ectoderm cell fate commitment" EXACT [] +is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer +relationship: part_of GO:0001705 ! ectoderm formation +relationship: part_of GO:0010668 ! ectodermal cell differentiation + +[Term] +id: GO:0001713 +name: ectodermal cell fate determination +namespace: biological_process +def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +synonym: "ectoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001712 ! ectodermal cell fate commitment + +[Term] +id: GO:0001714 +name: endodermal cell fate specification +namespace: biological_process +def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "endoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001711 ! endodermal cell fate commitment + +[Term] +id: GO:0001715 +name: ectodermal cell fate specification +namespace: biological_process +def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "ectoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001712 ! ectodermal cell fate commitment + +[Term] +id: GO:0001716 +name: L-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2] +synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.2] +synonym: "ophio-amino-acid oxidase activity" RELATED [EC:1.4.3.2] +xref: EC:1.4.3.2 +xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN +xref: Reactome:R-HSA-2160492 "IL4I1:FAD oxidises L-Phe to kPPV" +xref: RHEA:13781 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0001717 +name: conversion of seryl-tRNAsec to selenocys-tRNAsec +namespace: biological_process +def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X] +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0001720 +name: conversion of lysyl-tRNA to pyrrolysyl-tRNA +namespace: biological_process +def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0001721 +name: obsolete intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "IFAP" EXACT [] +synonym: "intermediate filament associated protein" EXACT [] +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001722 +name: obsolete type I intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "type I intermediate filament associated protein" EXACT [] +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001723 +name: obsolete type II intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "type II intermediate filament associated protein" EXACT [] +is_obsolete: true +replaced_by: GO:0005882 + +[Term] +id: GO:0001724 +name: obsolete type III intermediate filament associated protein +namespace: cellular_component +def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "type III intermediate filament associated protein" EXACT [] +is_obsolete: true +replaced_by: GO:0045098 + +[Term] +id: GO:0001725 +name: stress fiber +namespace: cellular_component +def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] +synonym: "actin cable" RELATED [GOC:mah] +synonym: "stress fibre" EXACT [] +is_a: GO:0042641 ! actomyosin +is_a: GO:0097517 ! contractile actin filament bundle + +[Term] +id: GO:0001726 +name: ruffle +namespace: cellular_component +def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] +synonym: "membrane ruffle" RELATED [] +is_a: GO:0120025 ! plasma membrane bounded cell projection +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0001727 +name: lipid kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0001729 +name: ceramide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] +synonym: "acylsphingosine kinase activity" RELATED [EC:2.7.1.138] +synonym: "ATP:ceramide 1-phosphotransferase activity" RELATED [EC:2.7.1.138] +xref: EC:2.7.1.138 +xref: MetaCyc:CERAMIDE-KINASE-RXN +xref: Reactome:R-HSA-1638845 "CERK phosphorylates CERA to form C1P" +xref: RHEA:17929 +is_a: GO:0001727 ! lipid kinase activity + +[Term] +id: GO:0001730 +name: 2'-5'-oligoadenylate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732] +synonym: "(2-5')oligo(A) synthetase activity" EXACT [] +synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] +synonym: "2-5A synthetase activity" EXACT [] +synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] +xref: EC:2.7.7.84 +xref: MetaCyc:RXN-10798 +xref: MetaCyc:RXN-13648 +xref: Reactome:R-HSA-8983680 "OAS1 produces oligoadenylates" +xref: Reactome:R-HSA-8985091 "OAS3 produces oligoadenylates" +xref: Reactome:R-HSA-8985104 "OAS2 produces oligoadenylates" +xref: RHEA:34407 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0001731 +name: formation of translation preinitiation complex +namespace: biological_process +def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] +comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. +synonym: "formation of translation pre-initiation complex" EXACT [] +synonym: "translation preinitiation complex assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:0001732 +name: formation of cytoplasmic translation initiation complex +namespace: biological_process +def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] +synonym: "cytoplasmic translation initiation complex assembly" EXACT [] +synonym: "formation of translation initiation complex" BROAD [] +synonym: "translation initiation complex assembly" BROAD [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:0001733 +name: galactosylceramide sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929, RHEA:43304] +synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "cerebroside sulfotransferase activity" EXACT [] +synonym: "galactocerebroside sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "galactolipid sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "galactosylceramide sulphotransferase activity" EXACT [] +synonym: "glycolipid sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "glycosphingolipid sulfotransferase activity" RELATED [EC:2.8.2.11] +synonym: "GSase" RELATED [EC:2.8.2.11] +xref: EC:2.8.2.11 +xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN +xref: RHEA:43304 +is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity + +[Term] +id: GO:0001734 +name: mRNA (N6-adenosine)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd] +xref: Reactome:R-HSA-72095 "Internal Methylation of mRNA" +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0001735 +name: prenylcysteine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd, RHEA:53892] +synonym: "prenylcysteine lyase activity" RELATED [EC:1.8.3.5] +synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" RELATED [EC:1.8.3.5] +xref: EC:1.8.3.5 +xref: MetaCyc:1.8.3.5-RXN +xref: RHEA:53892 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0001736 +name: establishment of planar polarity +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] +synonym: "establishment of planar cell polarity" NARROW [] +is_a: GO:0007164 ! establishment of tissue polarity +relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium + +[Term] +id: GO:0001737 +name: establishment of imaginal disc-derived wing hair orientation +namespace: biological_process +def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] +synonym: "establishment of wing hair orientation" EXACT [] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0001738 +name: morphogenesis of a polarized epithelium +namespace: biological_process +def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] +synonym: "epithelial polarization" EXACT [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0001739 +name: sex chromatin +namespace: cellular_component +def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732] +is_a: GO:0000792 ! heterochromatin +relationship: part_of GO:0000803 ! sex chromosome + +[Term] +id: GO:0001740 +name: Barr body +namespace: cellular_component +def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684] +xref: NIF_Subcellular:sao1571698684 +xref: Wikipedia:Barr_body +is_a: GO:0000228 ! nuclear chromosome +is_a: GO:0000805 ! X chromosome + +[Term] +id: GO:0001741 +name: XY body +namespace: cellular_component +def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0001742 +name: oenocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] +synonym: "oenocyte cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0001743 +name: lens placode formation +namespace: biological_process +def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] +synonym: "optic placode formation" RELATED [] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0001744 +name: insect visual primordium formation +namespace: biological_process +alt_id: GO:0007457 +def: "Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] +synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] +synonym: "optic lobe placode formation" EXACT [] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0001748 ! insect visual primordium development + +[Term] +id: GO:0001745 +name: compound eye morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] +synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0001746 +name: Bolwig's organ morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [PMID:6185380] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0055034 ! Bolwig's organ development + +[Term] +id: GO:0001748 +name: insect visual primordium development +namespace: biological_process +alt_id: GO:0048049 +def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] +synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] +synonym: "optic lobe placode development" EXACT [] +synonym: "optic placode development" BROAD [] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0001750 +name: photoreceptor outer segment +namespace: cellular_component +def: "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins." [GOC:cilia, GOC:krc, GOC:pde, ISBN:0824072820, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097733 ! photoreceptor cell cilium + +[Term] +id: GO:0001751 +name: compound eye photoreceptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] +is_a: GO:0001754 ! eye photoreceptor cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0001752 +name: compound eye photoreceptor fate commitment +namespace: biological_process +alt_id: GO:0007459 +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0042706 ! eye photoreceptor cell fate commitment +relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0001753 +name: obsolete adult eye photoreceptor development (sensu Drosophila) +namespace: biological_process +def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] +comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. +synonym: "adult eye photoreceptor development (sensu Drosophila)" EXACT [] +is_obsolete: true +consider: GO:0042051 + +[Term] +id: GO:0001754 +name: eye photoreceptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] +is_a: GO:0046530 ! photoreceptor cell differentiation +relationship: part_of GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0001755 +name: neural crest cell migration +namespace: biological_process +def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] +is_a: GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0014032 ! neural crest cell development + +[Term] +id: GO:0001756 +name: somitogenesis +namespace: biological_process +def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] +synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] +xref: Wikipedia:Somitogenesis +is_a: GO:0009952 ! anterior/posterior pattern specification +is_a: GO:0035282 ! segmentation +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0043009 ! chordate embryonic development +relationship: part_of GO:0061053 ! somite development + +[Term] +id: GO:0001757 +name: somite specification +namespace: biological_process +def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph] +is_a: GO:0007379 ! segment specification +is_a: GO:0009880 ! embryonic pattern specification +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0001758 +name: retinal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] +synonym: "cytosolic retinal dehydrogenase activity" RELATED [EC:1.2.1.36] +synonym: "retinal:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.36] +xref: EC:1.2.1.36 +xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-5362522 "ALDHs oxidise atRAL to atRA" +xref: Reactome:R-HSA-5696101 "ALDH8A1 oxidises 9cRAL to 9cRA" +xref: RHEA:16177 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0001759 +name: organ induction +namespace: biological_process +def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] +synonym: "induction of an organ" EXACT [] +is_a: GO:0003156 ! regulation of animal organ formation +is_a: GO:0031128 ! developmental induction +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +relationship: positively_regulates GO:0010092 ! specification of animal organ identity + +[Term] +id: GO:0001760 +name: aminocarboxymuconate-semialdehyde decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16557] +synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" RELATED [EC:4.1.1.45] +synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" RELATED [EC:4.1.1.45] +synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" RELATED [EC:4.1.1.45] +synonym: "ACMSD activity" EXACT [PMID:17288562] +synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" RELATED [EC:4.1.1.45] +synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" RELATED [EC:4.1.1.45] +synonym: "picolinic acid carboxylase activity" RELATED [EC:4.1.1.45] +synonym: "picolinic acid decarboxylase activity" RELATED [EC:4.1.1.45] +xref: EC:4.1.1.45 +xref: KEGG_REACTION:R04323 +xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN +xref: RHEA:16557 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0001761 +name: beta-alanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] +synonym: "beta-alanine transporter activity" BROAD [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0001762 +name: beta-alanine transport +namespace: biological_process +def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0001763 +name: morphogenesis of a branching structure +namespace: biological_process +def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] +synonym: "branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0001764 +name: neuron migration +namespace: biological_process +def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] +synonym: "neuron chemotaxis" EXACT [] +synonym: "neuron guidance" RELATED [] +synonym: "neuronal migration" EXACT [] +xref: Wikipedia:Neural_development#Neuron_migration +xref: Wikipedia:Neuron_migration +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0001765 +name: membrane raft assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] +synonym: "lipid raft assembly" EXACT [GOC:mah] +synonym: "lipid raft formation" RELATED [] +synonym: "membrane raft formation" RELATED [GOC:mah] +is_a: GO:0031579 ! membrane raft organization +is_a: GO:0071709 ! membrane assembly + +[Term] +id: GO:0001766 +name: membrane raft polarization +namespace: biological_process +def: "The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [PMID:12615889] +synonym: "lipid raft polarization" EXACT [] +synonym: "membrane polarization" EXACT [] +is_a: GO:0031580 ! membrane raft distribution + +[Term] +id: GO:0001767 +name: establishment of lymphocyte polarity +namespace: biological_process +def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "lymphocyte polarization" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +relationship: part_of GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0001768 +name: establishment of T cell polarity +namespace: biological_process +def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] +synonym: "establishment of T lymphocyte polarity" EXACT [] +synonym: "establishment of T-cell polarity" EXACT [] +synonym: "establishment of T-lymphocyte polarity" EXACT [] +synonym: "T cell polarization" EXACT [] +synonym: "T lymphocyte polarization" EXACT [] +synonym: "T-cell polarization" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0042110 ! T cell activation + +[Term] +id: GO:0001769 +name: establishment of B cell polarity +namespace: biological_process +def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] +comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. +synonym: "B cell polarization" EXACT [] +synonym: "B lymphocyte polarization" EXACT [] +synonym: "B-cell polarization" EXACT [] +synonym: "establishment of B lymphocyte polarity" EXACT [] +synonym: "establishment of B-cell polarity" EXACT [] +synonym: "establishment of B-lymphocyte polarity" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0042113 ! B cell activation + +[Term] +id: GO:0001770 +name: establishment of natural killer cell polarity +namespace: biological_process +def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] +synonym: "establishment of NK cell polarity" EXACT [] +synonym: "natural killer cell polarization" EXACT [] +synonym: "NK cell polarization" EXACT [] +is_a: GO:0001767 ! establishment of lymphocyte polarity +relationship: part_of GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0001771 +name: immunological synapse formation +namespace: biological_process +def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] +synonym: "formation of immunological synapse" EXACT [] +is_a: GO:0009988 ! cell-cell recognition +relationship: part_of GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0001772 +name: immunological synapse +namespace: cellular_component +def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] +synonym: "c-SMAC" NARROW [PMID:14724296] +synonym: "supramolecular activation cluster" EXACT [PMID:14724296] +xref: Wikipedia:Immunological_synapse +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0001773 +name: myeloid dendritic cell activation +namespace: biological_process +def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0001774 +name: microglial cell activation +namespace: biological_process +def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] +is_a: GO:0002269 ! leukocyte activation involved in inflammatory response +is_a: GO:0042116 ! macrophage activation +is_a: GO:0061900 ! glial cell activation + +[Term] +id: GO:0001775 +name: cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0001776 +name: leukocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] +comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. +synonym: "immune cell homeostasis" EXACT [] +synonym: "leucocyte homeostasis" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0001777 +name: T cell homeostatic proliferation +namespace: biological_process +def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] +synonym: "resting T cell proliferation" EXACT [] +synonym: "resting T-cell proliferation" EXACT [] +synonym: "T lymphocyte homeostatic proliferation" EXACT [] +synonym: "T-cell homeostatic proliferation" EXACT [] +synonym: "T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +relationship: part_of GO:0043029 ! T cell homeostasis + +[Term] +id: GO:0001778 +name: plasma membrane repair +namespace: biological_process +def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0001779 +name: natural killer cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "natural killer cell development" RELATED [GOC:add] +synonym: "NK cell differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0001780 +name: neutrophil homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266] +comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0001781 +name: neutrophil apoptotic process +namespace: biological_process +def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266] +synonym: "apoptosis of neutrophils" EXACT [] +synonym: "neutrophil apoptosis" NARROW [] +synonym: "neutrophil programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] +synonym: "programmed cell death, neutrophils" EXACT [] +is_a: GO:0006925 ! inflammatory cell apoptotic process +is_a: GO:0033028 ! myeloid cell apoptotic process +is_a: GO:0071887 ! leukocyte apoptotic process +relationship: part_of GO:0001780 ! neutrophil homeostasis + +[Term] +id: GO:0001782 +name: B cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429] +comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. +synonym: "B lymphocyte homeostasis" EXACT [] +synonym: "B-cell homeostasis" EXACT [] +synonym: "B-lymphocyte homeostasis" EXACT [] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0001783 +name: B cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] +synonym: "apoptosis of B cells" EXACT [] +synonym: "apoptosis of B lymphocytes" EXACT [] +synonym: "apoptosis of B-cells" EXACT [] +synonym: "apoptosis of B-lymphocytes" EXACT [] +synonym: "B cell apoptosis" NARROW [] +synonym: "B cell programmed cell death by apoptosis" EXACT [] +synonym: "B lymphocyte apoptosis" EXACT [] +synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "B-cell apoptosis" EXACT [] +synonym: "B-cell programmed cell death by apoptosis" EXACT [] +synonym: "B-lymphocyte apoptosis" EXACT [] +synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of B cells by apoptosis" EXACT [] +synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death of B-cells by apoptosis" EXACT [] +synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death, B cells" EXACT [] +synonym: "programmed cell death, B lymphocytes" EXACT [] +synonym: "programmed cell death, B-cells" EXACT [] +synonym: "programmed cell death, B-lymphocytes" EXACT [] +is_a: GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0001784 +name: phosphotyrosine residue binding +namespace: molecular_function +def: "Binding to a phosphorylated tyrosine residue within a protein." [PMID:14636584] +synonym: "phosphotyrosine binding" RELATED [] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0001785 +name: prostaglandin J receptor activity +namespace: molecular_function +def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] +synonym: "PGJ receptor activity" RELATED [] +synonym: "PGJ(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0001786 +name: phosphatidylserine binding +namespace: molecular_function +def: "Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0072341 ! modified amino acid binding + +[Term] +id: GO:0001787 +name: natural killer cell proliferation +namespace: biological_process +def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149] +synonym: "NK cell proliferation" EXACT [] +is_a: GO:0030101 ! natural killer cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0001788 +name: antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795] +synonym: "ADCC" EXACT [] +synonym: "antibody dependent cell death" EXACT [] +synonym: "antibody dependent cell killing" EXACT [] +synonym: "antibody-dependent cell death" EXACT [] +synonym: "antibody-dependent cell killing" EXACT [] +synonym: "type VI hypersensitivity" EXACT [] +xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity +xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity +is_a: GO:0001794 ! type IIa hypersensitivity +is_a: GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001790 +name: polymeric immunoglobulin binding +namespace: molecular_function +def: "Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0001791 +name: IgM binding +namespace: molecular_function +def: "Binding to an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0001792 +name: polymeric immunoglobulin receptor activity +namespace: molecular_function +def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0001793 +name: IgM receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0001794 +name: type IIa hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149] +comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. +is_a: GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0001795 +name: type IIb hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] +comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. +synonym: "type V hypersensitivity" EXACT [] +is_a: GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0001796 +name: regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001797 +name: negative regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "down regulation of type IIa hypersensitivity" EXACT [] +synonym: "down-regulation of type IIa hypersensitivity" EXACT [] +synonym: "downregulation of type IIa hypersensitivity" EXACT [] +synonym: "inhibition of type IIa hypersensitivity" NARROW [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0002893 ! negative regulation of type II hypersensitivity +relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001798 +name: positive regulation of type IIa hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "activation of type IIa hypersensitivity" NARROW [] +synonym: "stimulation of type IIa hypersensitivity" NARROW [] +synonym: "up regulation of type IIa hypersensitivity" EXACT [] +synonym: "up-regulation of type IIa hypersensitivity" EXACT [] +synonym: "upregulation of type IIa hypersensitivity" EXACT [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0002894 ! positive regulation of type II hypersensitivity +relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity + +[Term] +id: GO:0001799 +name: regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001800 +name: negative regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "down regulation of type IIb hypersensitivity" EXACT [] +synonym: "down-regulation of type IIb hypersensitivity" EXACT [] +synonym: "downregulation of type IIb hypersensitivity" EXACT [] +synonym: "inhibition of type IIb hypersensitivity" NARROW [] +is_a: GO:0001799 ! regulation of type IIb hypersensitivity +is_a: GO:0002893 ! negative regulation of type II hypersensitivity +relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001801 +name: positive regulation of type IIb hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "activation of type IIb hypersensitivity" NARROW [] +synonym: "stimulation of type IIb hypersensitivity" NARROW [] +synonym: "up regulation of type IIb hypersensitivity" EXACT [] +synonym: "up-regulation of type IIb hypersensitivity" EXACT [] +synonym: "upregulation of type IIb hypersensitivity" EXACT [] +is_a: GO:0001799 ! regulation of type IIb hypersensitivity +is_a: GO:0002894 ! positive regulation of type II hypersensitivity +relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity + +[Term] +id: GO:0001802 +name: type III hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149] +comment: Note that the Arthus reaction is an example of type III hypersensitivity. +xref: Wikipedia:Type_III_hypersensitivity +is_a: GO:0002444 ! myeloid leukocyte mediated immunity +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0001803 +name: regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001804 +name: negative regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "down regulation of type III hypersensitivity" EXACT [] +synonym: "down-regulation of type III hypersensitivity" EXACT [] +synonym: "downregulation of type III hypersensitivity" EXACT [] +synonym: "inhibition of type III hypersensitivity" NARROW [] +is_a: GO:0001803 ! regulation of type III hypersensitivity +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001805 +name: positive regulation of type III hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "activation of type III hypersensitivity" NARROW [] +synonym: "stimulation of type III hypersensitivity" NARROW [] +synonym: "up regulation of type III hypersensitivity" EXACT [] +synonym: "up-regulation of type III hypersensitivity" EXACT [] +synonym: "upregulation of type III hypersensitivity" EXACT [] +is_a: GO:0001803 ! regulation of type III hypersensitivity +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0001802 ! type III hypersensitivity + +[Term] +id: GO:0001806 +name: type IV hypersensitivity +namespace: biological_process +alt_id: GO:0016069 +def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149] +synonym: "delayed hypersensitivity response" EXACT [] +synonym: "delayed-type hypersensitivity" EXACT [] +xref: Wikipedia:Type_IV_hypersensitivity +is_a: GO:0002456 ! T cell mediated immunity +is_a: GO:0002524 ! hypersensitivity + +[Term] +id: GO:0001807 +name: regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001808 +name: negative regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "down regulation of type IV hypersensitivity" EXACT [] +synonym: "down-regulation of type IV hypersensitivity" EXACT [] +synonym: "downregulation of type IV hypersensitivity" EXACT [] +synonym: "inhibition of type IV hypersensitivity" NARROW [] +is_a: GO:0001807 ! regulation of type IV hypersensitivity +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002884 ! negative regulation of hypersensitivity +relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001809 +name: positive regulation of type IV hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "activation of type IV hypersensitivity" NARROW [] +synonym: "stimulation of type IV hypersensitivity" NARROW [] +synonym: "up regulation of type IV hypersensitivity" EXACT [] +synonym: "up-regulation of type IV hypersensitivity" EXACT [] +synonym: "upregulation of type IV hypersensitivity" EXACT [] +is_a: GO:0001807 ! regulation of type IV hypersensitivity +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002885 ! positive regulation of hypersensitivity +relationship: positively_regulates GO:0001806 ! type IV hypersensitivity + +[Term] +id: GO:0001810 +name: regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001811 +name: negative regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "down regulation of type I hypersensitivity" EXACT [] +synonym: "down-regulation of type I hypersensitivity" EXACT [] +synonym: "downregulation of type I hypersensitivity" EXACT [] +synonym: "inhibition of type I hypersensitivity" NARROW [] +is_a: GO:0001810 ! regulation of type I hypersensitivity +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001812 +name: positive regulation of type I hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "activation of type I hypersensitivity" NARROW [] +synonym: "stimulation of type I hypersensitivity" NARROW [] +synonym: "up regulation of type I hypersensitivity" EXACT [] +synonym: "up-regulation of type I hypersensitivity" EXACT [] +synonym: "upregulation of type I hypersensitivity" EXACT [] +is_a: GO:0001810 ! regulation of type I hypersensitivity +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0001813 +name: regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "regulation of antibody dependent cell death" EXACT [] +synonym: "regulation of antibody dependent cell killing" EXACT [] +synonym: "regulation of antibody-dependent cell death" EXACT [] +synonym: "regulation of antibody-dependent cell killing" EXACT [] +is_a: GO:0001796 ! regulation of type IIa hypersensitivity +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001814 +name: negative regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "negative regulation of antibody dependent cell death" EXACT [] +synonym: "negative regulation of antibody dependent cell killing" EXACT [] +synonym: "negative regulation of antibody-dependent cell death" EXACT [] +synonym: "negative regulation of antibody-dependent cell killing" EXACT [] +is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity +is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001815 +name: positive regulation of antibody-dependent cellular cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "positive regulation of antibody dependent cell death" EXACT [] +synonym: "positive regulation of antibody dependent cell killing" EXACT [] +synonym: "positive regulation of antibody-dependent cell death" EXACT [] +synonym: "positive regulation of antibody-dependent cell killing" EXACT [] +synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] +synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] +synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] +is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity +is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity + +[Term] +id: GO:0001816 +name: cytokine production +namespace: biological_process +alt_id: GO:0042032 +alt_id: GO:0042089 +alt_id: GO:0042107 +alt_id: GO:0050663 +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "cytokine biosynthetic process" NARROW [] +synonym: "cytokine metabolic process" NARROW [] +synonym: "cytokine secretion" NARROW [] +synonym: "interferon production" NARROW [GOC:add, GOC:mah] +synonym: "interferon secretion" NARROW [GOC:add, GOC:mah] +synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] +synonym: "interleukin secretion" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] +is_a: GO:0010467 ! gene expression +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0001817 +name: regulation of cytokine production +namespace: biological_process +alt_id: GO:0042035 +alt_id: GO:0050707 +def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] +synonym: "regulation of cytokine anabolism" EXACT [] +synonym: "regulation of cytokine biosynthesis" EXACT [] +synonym: "regulation of cytokine biosynthetic process" NARROW [] +synonym: "regulation of cytokine formation" EXACT [] +synonym: "regulation of cytokine secretion" NARROW [] +synonym: "regulation of cytokine synthesis" EXACT [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001818 +name: negative regulation of cytokine production +namespace: biological_process +alt_id: GO:0042036 +alt_id: GO:0050710 +def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] +synonym: "down regulation of cytokine biosynthetic process" EXACT [] +synonym: "down regulation of cytokine production" EXACT [] +synonym: "down-regulation of cytokine biosynthetic process" EXACT [] +synonym: "down-regulation of cytokine production" EXACT [] +synonym: "downregulation of cytokine biosynthetic process" EXACT [] +synonym: "downregulation of cytokine production" EXACT [] +synonym: "inhibition of cytokine biosynthetic process" NARROW [] +synonym: "inhibition of cytokine production" NARROW [] +synonym: "negative regulation of cytokine anabolism" EXACT [] +synonym: "negative regulation of cytokine biosynthesis" EXACT [] +synonym: "negative regulation of cytokine biosynthetic process" NARROW [] +synonym: "negative regulation of cytokine formation" EXACT [] +synonym: "negative regulation of cytokine secretion" NARROW [] +synonym: "negative regulation of cytokine synthesis" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001819 +name: positive regulation of cytokine production +namespace: biological_process +alt_id: GO:0042108 +alt_id: GO:0050715 +def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] +synonym: "activation of cytokine production" NARROW [] +synonym: "positive regulation of cytokine biosynthetic process" NARROW [] +synonym: "positive regulation of cytokine secretion" NARROW [] +synonym: "stimulation of cytokine production" NARROW [] +synonym: "up regulation of cytokine production" EXACT [] +synonym: "up-regulation of cytokine production" EXACT [] +synonym: "upregulation of cytokine production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0001820 +name: serotonin secretion +namespace: biological_process +def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] +synonym: "5-HT secretion" EXACT [] +synonym: "5-hydroxytryptamine secretion" EXACT [] +synonym: "serotonin release" RELATED [GOC:tb] +is_a: GO:0006837 ! serotonin transport +is_a: GO:0023061 ! signal release + +[Term] +id: GO:0001821 +name: histamine secretion +namespace: biological_process +def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149] +is_a: GO:0046903 ! secretion +is_a: GO:0051608 ! histamine transport + +[Term] +id: GO:0001822 +name: kidney development +namespace: biological_process +def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] +synonym: "nephrogenesis" RELATED [GOC:rph] +xref: Wikipedia:Kidney_development +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0001823 +name: mesonephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] +synonym: "Wolffian body development" EXACT [GOC:dph] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0001824 +name: blastocyst development +namespace: biological_process +def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001701 ! in utero embryonic development + +[Term] +id: GO:0001825 +name: blastocyst formation +namespace: biological_process +def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001826 +name: inner cell mass cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001825 ! blastocyst formation + +[Term] +id: GO:0001827 +name: inner cell mass cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001826 ! inner cell mass cell differentiation + +[Term] +id: GO:0001828 +name: inner cell mass cellular morphogenesis +namespace: biological_process +def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001826 ! inner cell mass cell differentiation + +[Term] +id: GO:0001829 +name: trophectodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. +synonym: "trophectoderm cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001825 ! blastocyst formation + +[Term] +id: GO:0001830 +name: trophectodermal cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. +synonym: "trophectoderm cell fate commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001829 ! trophectodermal cell differentiation + +[Term] +id: GO:0001831 +name: trophectodermal cellular morphogenesis +namespace: biological_process +def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. +synonym: "trophectoderm cellular morphogenesis" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001829 ! trophectodermal cell differentiation + +[Term] +id: GO:0001832 +name: blastocyst growth +namespace: biological_process +def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001833 +name: inner cell mass cell proliferation +namespace: biological_process +def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0001832 ! blastocyst growth + +[Term] +id: GO:0001834 +name: trophectodermal cell proliferation +namespace: biological_process +def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. +synonym: "trophectoderm cell proliferation" EXACT [] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0001832 ! blastocyst growth + +[Term] +id: GO:0001835 +name: blastocyst hatching +namespace: biological_process +def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] +comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. +is_a: GO:0035188 ! hatching +relationship: part_of GO:0001824 ! blastocyst development + +[Term] +id: GO:0001836 +name: release of cytochrome c from mitochondria +namespace: biological_process +def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] +comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011. +is_a: GO:0008637 ! apoptotic mitochondrial changes +relationship: part_of GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0001837 +name: epithelial to mesenchymal transition +namespace: biological_process +def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] +synonym: "EMT" EXACT [] +synonym: "epithelial-mesenchymal transition" EXACT [] +synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] +is_a: GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0001838 +name: embryonic epithelial tube formation +namespace: biological_process +def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium + +[Term] +id: GO:0001839 +name: neural plate morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001840 ! neural plate development + +[Term] +id: GO:0001840 +name: neural plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0001841 +name: neural tube formation +namespace: biological_process +alt_id: GO:0001679 +def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] +synonym: "neural tube morphogenesis" EXACT [GOC:dph] +synonym: "neurulation" EXACT [] +xref: Wikipedia:Neurulation +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0001842 +name: neural fold formation +namespace: biological_process +def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] +synonym: "neural groove formation" RELATED [GOC:dph] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0001843 +name: neural tube closure +namespace: biological_process +def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] +is_a: GO:0060606 ! tube closure +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0001844 +name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +namespace: biological_process +def: "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892] +comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. +synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [] +synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb] +synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [] +synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [] +is_a: GO:0051204 ! protein insertion into mitochondrial membrane +relationship: part_of GO:0097345 ! mitochondrial outer membrane permeabilization + +[Term] +id: GO:0001845 +name: phagolysosome assembly +namespace: biological_process +def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149] +synonym: "late phagosome biosynthesis" RELATED [] +synonym: "late phagosome formation" RELATED [] +synonym: "phagolysosome formation" RELATED [GOC:mah] +is_a: GO:0007040 ! lysosome organization +is_a: GO:0016050 ! vesicle organization +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0006909 ! phagocytosis +relationship: part_of GO:0090382 ! phagosome maturation + +[Term] +id: GO:0001846 +name: opsonin binding +namespace: molecular_function +def: "Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149] +comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001847 +name: opsonin receptor activity +namespace: molecular_function +def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0001848 +name: complement binding +namespace: molecular_function +def: "Binding to a component or product of the complement cascade." [GOC:add, ISBN:0781735149] +comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001849 +name: complement component C1q complex binding +namespace: molecular_function +def: "Binding to a C1q complex, a component of the classical complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0001850 +name: complement component C3a binding +namespace: molecular_function +def: "Binding to a C3a product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001851 +name: complement component C3b binding +namespace: molecular_function +def: "Binding to a C3b product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001852 +name: complement component iC3b binding +namespace: molecular_function +def: "Binding to a iC3b product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001853 +name: complement component C3dg binding +namespace: molecular_function +def: "Binding to a C3dg product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001854 +name: complement component C3d binding +namespace: molecular_function +def: "Binding to a C3d product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001855 +name: complement component C4b binding +namespace: molecular_function +def: "Binding to a C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001846 ! opsonin binding +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001856 +name: complement component C5a binding +namespace: molecular_function +def: "Binding to a C5a product of the complement cascade." [GOC:add, ISBN:0781735149] +is_a: GO:0001848 ! complement binding + +[Term] +id: GO:0001857 +name: complement component C1q receptor activity +namespace: molecular_function +def: "Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001858 +name: complement component iC3b receptor activity +namespace: molecular_function +def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001859 +name: complement component C3dg receptor activity +namespace: molecular_function +def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001860 +name: complement component C3d receptor activity +namespace: molecular_function +def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001861 +name: complement component C4b receptor activity +namespace: molecular_function +def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0001862 +name: collectin binding +namespace: molecular_function +def: "Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149] +comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). +is_a: GO:0001846 ! opsonin binding + +[Term] +id: GO:0001863 +name: collectin receptor activity +namespace: molecular_function +def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). +is_a: GO:0001847 ! opsonin receptor activity + +[Term] +id: GO:0001864 +name: pentraxin binding +namespace: molecular_function +def: "Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149] +comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). +is_a: GO:0001846 ! opsonin binding + +[Term] +id: GO:0001865 +name: NK T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "natural killer T cell differentiation" EXACT [] +synonym: "natural T cell differentiation" EXACT [] +synonym: "NK T cell development" RELATED [GOC:add] +synonym: "NK T lymphocyte differentiation" EXACT [] +synonym: "NK T-cell differentiation" EXACT [] +synonym: "NK T-lymphocyte differentiation" EXACT [] +synonym: "NKT cell differentiation" EXACT [] +synonym: "NT cell differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0001866 +name: NK T cell proliferation +namespace: biological_process +def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. +synonym: "natural killer T cell proliferation" EXACT [] +synonym: "natural T cell proliferation" EXACT [] +synonym: "NK T lymphocyte proliferation" EXACT [] +synonym: "NK T-cell proliferation" EXACT [] +synonym: "NK T-lymphocyte proliferation" EXACT [] +synonym: "NKT cell proliferation" EXACT [] +synonym: "NT cell proliferation" EXACT [] +is_a: GO:0046633 ! alpha-beta T cell proliferation +is_a: GO:0051132 ! NK T cell activation + +[Term] +id: GO:0001867 +name: complement activation, lectin pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] +comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. +synonym: "complement cascade, lectin pathway" EXACT [GOC:add] +is_a: GO:0006956 ! complement activation +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0001868 +name: regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149] +synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add] +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001869 +name: negative regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] +synonym: "down regulation of complement activation, lectin pathway" EXACT [] +synonym: "down-regulation of complement activation, lectin pathway" EXACT [] +synonym: "downregulation of complement activation, lectin pathway" EXACT [] +synonym: "inhibition of complement activation, lectin pathway" NARROW [] +synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add] +is_a: GO:0001868 ! regulation of complement activation, lectin pathway +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001870 +name: positive regulation of complement activation, lectin pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] +synonym: "activation of complement activation, lectin pathway" NARROW [] +synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add] +synonym: "stimulation of complement activation, lectin pathway" NARROW [] +synonym: "up regulation of complement activation, lectin pathway" EXACT [] +synonym: "up-regulation of complement activation, lectin pathway" EXACT [] +synonym: "upregulation of complement activation, lectin pathway" EXACT [] +is_a: GO:0001868 ! regulation of complement activation, lectin pathway +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway + +[Term] +id: GO:0001871 +name: obsolete pattern binding +namespace: molecular_function +def: "OBSOLETE. Binding to a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] +comment: This term was obsoleted because it was an unnecessary grouping term. +synonym: "pattern recognition activity" BROAD [] +is_obsolete: true + +[Term] +id: GO:0001872 +name: (1->3)-beta-D-glucan binding +namespace: molecular_function +alt_id: GO:0080087 +def: "Binding to a (1->3)-beta-D-glucan." [PMID:14707091] +synonym: "1,3-beta-D-glucan binding" EXACT [] +synonym: "callose binding" NARROW [] +synonym: "zymosan binding" NARROW [GOC:tb] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0001873 +name: polysaccharide immune receptor activity +namespace: molecular_function +def: "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [PMID:14707091] +synonym: "polysaccharide receptor activity" BROAD [] +is_a: GO:0038187 ! pattern recognition receptor activity + +[Term] +id: GO:0001874 +name: (1->3)-beta-D-glucan immune receptor activity +namespace: molecular_function +def: "Combining with (1->3)-beta-D-glucans to initiate an innate immune response." [PMID:14707091] +synonym: "(1,3)-beta-D-glucan receptor activity" EXACT [] +synonym: "(1->3)-beta-D-glucan receptor activity" BROAD [] +synonym: "1,3-beta-D-glucan receptor activity" EXACT [] +synonym: "beta-1,3-D-glucan receptor activity" EXACT [] +synonym: "zymosan receptor activity" NARROW [GOC:tb] +is_a: GO:0001873 ! polysaccharide immune receptor activity + +[Term] +id: GO:0001875 +name: lipopolysaccharide immune receptor activity +namespace: molecular_function +def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] +synonym: "endotoxin receptor activity" BROAD [] +synonym: "lipopolysaccharide receptor activity" BROAD [] +synonym: "LPS receptor activity" EXACT [] +is_a: GO:0038187 ! pattern recognition receptor activity + +[Term] +id: GO:0001876 +name: lipoarabinomannan binding +namespace: molecular_function +def: "Binding to lipoarabinomannan." [PMID:10586073] +synonym: "LAM binding" EXACT [] +is_a: GO:0034235 ! GPI anchor binding + +[Term] +id: GO:0001877 +name: lipoarabinomannan immune receptor activity +namespace: molecular_function +def: "Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response." [PMID:10586073] +synonym: "LAM receptor activity" EXACT [] +synonym: "lipoarabinomannan receptor activity" BROAD [] +is_a: GO:0038187 ! pattern recognition receptor activity + +[Term] +id: GO:0001878 +name: response to yeast +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] +comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0001879 +name: detection of yeast +namespace: biological_process +def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] +is_a: GO:0001878 ! response to yeast +is_a: GO:0016046 ! detection of fungus + +[Term] +id: GO:0001880 +name: Mullerian duct regression +namespace: biological_process +def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0001881 +name: receptor recycling +namespace: biological_process +def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0001882 +name: nucleoside binding +namespace: molecular_function +def: "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] +subset: goslim_pir +is_a: GO:0036094 ! small molecule binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:0097367 ! carbohydrate derivative binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0001883 +name: purine nucleoside binding +namespace: molecular_function +def: "Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0001884 +name: pyrimidine nucleoside binding +namespace: molecular_function +def: "Binding to a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0001885 +name: endothelial cell development +namespace: biological_process +def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0001886 +name: endothelial cell morphogenesis +namespace: biological_process +def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003382 ! epithelial cell morphogenesis +relationship: part_of GO:0001885 ! endothelial cell development + +[Term] +id: GO:0001887 +name: selenium compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456] +synonym: "selenium compound metabolism" EXACT [] +synonym: "selenium metabolic process" EXACT [] +synonym: "selenium metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0001888 +name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223, RHEA:16221] +synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223] +synonym: "alpha-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.223] +synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223] +synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.223] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.223] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.223] +xref: EC:2.4.1.223 +xref: MetaCyc:2.4.1.223-RXN +xref: RHEA:16221 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0001889 +name: liver development +namespace: biological_process +def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0061008 ! hepaticobiliary system development + +[Term] +id: GO:0001890 +name: placenta development +namespace: biological_process +def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] +synonym: "placental development" EXACT [] +synonym: "placentation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048513 ! animal organ development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0001891 +name: phagocytic cup +namespace: cellular_component +def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0001892 +name: embryonic placenta development +namespace: biological_process +def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] +synonym: "fetal placenta development" EXACT [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048568 ! embryonic organ development +relationship: part_of GO:0001701 ! in utero embryonic development +relationship: part_of GO:0001890 ! placenta development + +[Term] +id: GO:0001893 +name: maternal placenta development +namespace: biological_process +def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] +synonym: "decidua development" RELATED [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +is_a: GO:0060135 ! maternal process involved in female pregnancy +relationship: part_of GO:0001890 ! placenta development + +[Term] +id: GO:0001894 +name: tissue homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] +synonym: "tissue maintenance" NARROW [GOC:add] +is_a: GO:0060249 ! anatomical structure homeostasis +relationship: part_of GO:0048871 ! multicellular organismal homeostasis + +[Term] +id: GO:0001895 +name: retina homeostasis +namespace: biological_process +def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0001896 +name: autolysis +namespace: biological_process +def: "A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation." [GOC:add, GOC:jh2, GOC:mtg_apoptosis, PMID:10974124, PMID:19286987, PMID:26811896] +xref: Wikipedia:Autolysis +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0001897 +name: cytolysis by symbiont of host cells +namespace: biological_process +def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] +synonym: "cytolysis by organism of host cells" EXACT [] +synonym: "pathogenesis" RELATED [] +is_a: GO:0001907 ! killing by symbiont of host cells + +[Term] +id: GO:0001898 +name: regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001899 +name: negative regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] +synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001900 +name: positive regulation of cytolysis by symbiont of host cells +namespace: biological_process +def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] +synonym: "activation by symbiont of cytolysis of host cells" NARROW [] +synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] +synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] +synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] +is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0001905 +name: activation of membrane attack complex +namespace: biological_process +def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149] +synonym: "activation of MAC" EXACT [] +synonym: "activation of TCC" NARROW [] +synonym: "activation of terminal complement complex" NARROW [GOC:add] +synonym: "activation of the terminal complement cascade" NARROW [] +synonym: "MAC assembly" EXACT [GOC:rl] +synonym: "MAC formation" EXACT [GOC:rl] +synonym: "membrane attack complex assembly" EXACT [GOC:rl] +synonym: "membrane attack complex formation" EXACT [GOC:rl] +is_a: GO:0006956 ! complement activation + +[Term] +id: GO:0001906 +name: cell killing +namespace: biological_process +def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] +subset: goslim_pir +synonym: "necrosis" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0001907 +name: killing by symbiont of host cells +namespace: biological_process +def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] +synonym: "pathogenesis" RELATED [] +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0001909 +name: leukocyte mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:11911826] +comment: Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. +synonym: "immune cell mediated cell death" EXACT [] +synonym: "immune cell mediated cell killing" EXACT [] +synonym: "immune cell mediated cytotoxicity" EXACT [] +synonym: "leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001906 ! cell killing +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0001910 +name: regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] +synonym: "regulation of immune cell mediated cell death" EXACT [] +synonym: "regulation of immune cell mediated cell killing" EXACT [] +synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +is_a: GO:0031341 ! regulation of cell killing +relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001911 +name: negative regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] +synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] +synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0031342 ! negative regulation of cell killing +relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001912 +name: positive regulation of leukocyte mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] +synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] +synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] +synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] +synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] +synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] +synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0031343 ! positive regulation of cell killing +relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity + +[Term] +id: GO:0001913 +name: T cell mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. +synonym: "T cell mediated apoptosis" EXACT [] +synonym: "T cell mediated cell death" EXACT [] +synonym: "T cell mediated cell killing" EXACT [] +synonym: "T cell mediated cytolysis" RELATED [] +synonym: "T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "T-cell mediated apoptosis" EXACT [] +synonym: "T-cell mediated cell death" EXACT [] +synonym: "T-cell mediated cell killing" EXACT [] +synonym: "T-cell mediated cytotoxicity" EXACT [] +synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0001914 +name: regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "regulation of T cell mediated apoptosis" EXACT [] +synonym: "regulation of T cell mediated cell death" EXACT [] +synonym: "regulation of T cell mediated cell killing" EXACT [] +synonym: "regulation of T cell mediated cytolysis" RELATED [] +synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "regulation of T-cell mediated apoptosis" EXACT [] +synonym: "regulation of T-cell mediated cell death" EXACT [] +synonym: "regulation of T-cell mediated cell killing" EXACT [] +synonym: "regulation of T-cell mediated cytolysis" RELATED [] +synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001915 +name: negative regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] +synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] +synonym: "negative regulation of T cell mediated apoptosis" EXACT [] +synonym: "negative regulation of T cell mediated cell death" EXACT [] +synonym: "negative regulation of T cell mediated cell killing" EXACT [] +synonym: "negative regulation of T cell mediated cytolysis" RELATED [] +synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] +synonym: "negative regulation of T-cell mediated cell death" EXACT [] +synonym: "negative regulation of T-cell mediated cell killing" EXACT [] +synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] +synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001916 +name: positive regulation of T cell mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "activation of T cell mediated cytotoxicity" NARROW [] +synonym: "positive regulation of T cell mediated apoptosis" EXACT [] +synonym: "positive regulation of T cell mediated cell death" EXACT [] +synonym: "positive regulation of T cell mediated cell killing" EXACT [] +synonym: "positive regulation of T cell mediated cytolysis" RELATED [] +synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] +synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] +synonym: "positive regulation of T-cell mediated cell death" EXACT [] +synonym: "positive regulation of T-cell mediated cell killing" EXACT [] +synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] +synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] +synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] +synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] +synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0001917 +name: photoreceptor inner segment +namespace: cellular_component +def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] +subset: goslim_pir +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0001918 +name: farnesylated protein binding +namespace: molecular_function +def: "Binding to a farnesylated protein." [GOC:add, PMID:14555765] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001919 +name: regulation of receptor recycling +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001920 +name: negative regulation of receptor recycling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] +synonym: "down regulation of receptor recycling" EXACT [] +synonym: "down-regulation of receptor recycling" EXACT [] +synonym: "downregulation of receptor recycling" EXACT [] +synonym: "inhibition of receptor recycling" NARROW [] +is_a: GO:0001919 ! regulation of receptor recycling +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0031324 ! negative regulation of cellular metabolic process +relationship: negatively_regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001921 +name: positive regulation of receptor recycling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] +synonym: "activation of receptor recycling" NARROW [] +synonym: "stimulation of receptor recycling" NARROW [] +synonym: "up regulation of receptor recycling" EXACT [] +synonym: "up-regulation of receptor recycling" EXACT [] +synonym: "upregulation of receptor recycling" EXACT [] +is_a: GO:0001919 ! regulation of receptor recycling +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0031325 ! positive regulation of cellular metabolic process +relationship: positively_regulates GO:0001881 ! receptor recycling + +[Term] +id: GO:0001922 +name: B-1 B cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] +comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. +synonym: "B-1 B lymphocyte homeostasis" EXACT [] +synonym: "B-1 B-cell homeostasis" EXACT [] +synonym: "B-1 B-lymphocyte homeostasis" EXACT [] +is_a: GO:0001782 ! B cell homeostasis + +[Term] +id: GO:0001923 +name: B-1 B cell differentiation +namespace: biological_process +def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] +synonym: "B-1 B cell development" RELATED [GOC:add] +synonym: "B-1 B lymphocyte differentiation" EXACT [] +synonym: "B-1 B-cell differentiation" EXACT [] +synonym: "B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0002335 ! mature B cell differentiation + +[Term] +id: GO:0001924 +name: regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of B-1 B cell development" RELATED [GOC:add] +synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "regulation of B-1 B-cell differentiation" EXACT [] +synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001925 +name: negative regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of B-1 B cell differentiation" EXACT [] +synonym: "down-regulation of B-1 B cell differentiation" EXACT [] +synonym: "downregulation of B-1 B cell differentiation" EXACT [] +synonym: "inhibition of B-1 B cell differentiation" NARROW [] +synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] +synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] +synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] +is_a: GO:0001924 ! regulation of B-1 B cell differentiation +is_a: GO:0045578 ! negative regulation of B cell differentiation +relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001926 +name: positive regulation of B-1 B cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of B-1 B cell differentiation" NARROW [] +synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] +synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] +synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] +synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] +synonym: "stimulation of B-1 B cell differentiation" NARROW [] +synonym: "up regulation of B-1 B cell differentiation" EXACT [] +synonym: "up-regulation of B-1 B cell differentiation" EXACT [] +synonym: "upregulation of B-1 B cell differentiation" EXACT [] +is_a: GO:0001924 ! regulation of B-1 B cell differentiation +is_a: GO:0045579 ! positive regulation of B cell differentiation +relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0001927 +name: exocyst assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis + +[Term] +id: GO:0001928 +name: regulation of exocyst assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] +comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0106020 ! regulation of vesicle docking +relationship: regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001929 +name: negative regulation of exocyst assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd] +synonym: "down regulation of exocyst assembly" EXACT [] +synonym: "down-regulation of exocyst assembly" EXACT [] +synonym: "downregulation of exocyst assembly" EXACT [] +synonym: "inhibition of exocyst assembly" NARROW [] +is_a: GO:0001928 ! regulation of exocyst assembly +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0045920 ! negative regulation of exocytosis +relationship: negatively_regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001930 +name: positive regulation of exocyst assembly +namespace: biological_process +def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] +synonym: "activation of exocyst assembly" NARROW [] +synonym: "stimulation of exocyst assembly" NARROW [] +synonym: "up regulation of exocyst assembly" EXACT [] +synonym: "up-regulation of exocyst assembly" EXACT [] +synonym: "upregulation of exocyst assembly" EXACT [] +is_a: GO:0001928 ! regulation of exocyst assembly +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +relationship: positively_regulates GO:0001927 ! exocyst assembly + +[Term] +id: GO:0001931 +name: uropod +namespace: cellular_component +def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] +synonym: "distal pole complex" RELATED [] +synonym: "retractile pole" RELATED [] +synonym: "uropodium" EXACT [] +is_a: GO:0120025 ! plasma membrane bounded cell projection +relationship: part_of GO:0031254 ! cell trailing edge + +[Term] +id: GO:0001932 +name: regulation of protein phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] +synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0042325 ! regulation of phosphorylation +relationship: regulates GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0001933 +name: negative regulation of protein phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +synonym: "down regulation of protein amino acid phosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "downregulation of protein amino acid phosphorylation" EXACT [] +synonym: "inhibition of protein amino acid phosphorylation" NARROW [] +synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0042326 ! negative regulation of phosphorylation +relationship: negatively_regulates GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0001934 +name: positive regulation of protein phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] +synonym: "activation of protein amino acid phosphorylation" NARROW [] +synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] +synonym: "stimulation of protein amino acid phosphorylation" NARROW [] +synonym: "up regulation of protein amino acid phosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] +synonym: "upregulation of protein amino acid phosphorylation" EXACT [] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0042327 ! positive regulation of phosphorylation +relationship: positively_regulates GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0001935 +name: endothelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0001936 +name: regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001937 +name: negative regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] +synonym: "down regulation of endothelial cell proliferation" EXACT [] +synonym: "down-regulation of endothelial cell proliferation" EXACT [] +synonym: "downregulation of endothelial cell proliferation" EXACT [] +synonym: "inhibition of endothelial cell proliferation" NARROW [] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001938 +name: positive regulation of endothelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] +synonym: "activation of endothelial cell proliferation" NARROW [] +synonym: "stimulation of endothelial cell proliferation" NARROW [] +synonym: "up regulation of endothelial cell proliferation" EXACT [] +synonym: "up-regulation of endothelial cell proliferation" EXACT [] +synonym: "upregulation of endothelial cell proliferation" EXACT [] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: positively_regulates GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0001939 +name: female pronucleus +namespace: cellular_component +def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732] +is_a: GO:0045120 ! pronucleus + +[Term] +id: GO:0001940 +name: male pronucleus +namespace: cellular_component +def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732] +is_a: GO:0045120 ! pronucleus + +[Term] +id: GO:0001941 +name: postsynaptic membrane organization +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr] +synonym: "post-synaptic membrane organization" EXACT [] +synonym: "postsynaptic membrane organisation" EXACT [] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0099173 ! postsynapse organization + +[Term] +id: GO:0001942 +name: hair follicle development +namespace: biological_process +alt_id: GO:0001943 +def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] +is_a: GO:0022405 ! hair cycle process +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0098773 ! skin epidermis development + +[Term] +id: GO:0001944 +name: vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] +synonym: "vascular system development" RELATED [] +is_a: GO:0048731 ! system development +relationship: part_of GO:0072359 ! circulatory system development + +[Term] +id: GO:0001945 +name: lymph vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001944 ! vasculature development + +[Term] +id: GO:0001946 +name: lymphangiogenesis +namespace: biological_process +def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] +synonym: "lymph vessel formation" EXACT systematic_synonym [] +xref: Wikipedia:Lymphangiogenesis +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0036303 ! lymph vessel morphogenesis + +[Term] +id: GO:0001947 +name: heart looping +namespace: biological_process +def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232] +synonym: "cardiac looping" EXACT [] +is_a: GO:0003143 ! embryonic heart tube morphogenesis +relationship: part_of GO:0061371 ! determination of heart left/right asymmetry + +[Term] +id: GO:0001949 +name: sebaceous gland cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] +synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] +is_a: GO:0009913 ! epidermal cell differentiation +relationship: part_of GO:0048733 ! sebaceous gland development + +[Term] +id: GO:0001950 +name: obsolete plasma membrane enriched fraction +namespace: cellular_component +def: "OBSOLETE. The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "plasma membrane enriched fraction" EXACT [] +synonym: "PME fraction" RELATED [GOC:mah] +is_obsolete: true +consider: GO:0005886 + +[Term] +id: GO:0001951 +name: intestinal D-glucose absorption +namespace: biological_process +def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] +is_a: GO:0106001 ! intestinal hexose absorption + +[Term] +id: GO:0001952 +name: regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001953 +name: negative regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] +synonym: "down regulation of cell-matrix adhesion" EXACT [] +synonym: "down-regulation of cell-matrix adhesion" EXACT [] +synonym: "downregulation of cell-matrix adhesion" EXACT [] +synonym: "inhibition of cell-matrix adhesion" NARROW [] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +is_a: GO:0010812 ! negative regulation of cell-substrate adhesion +relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001954 +name: positive regulation of cell-matrix adhesion +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] +synonym: "activation of cell-matrix adhesion" NARROW [] +synonym: "stimulation of cell-matrix adhesion" NARROW [] +synonym: "up regulation of cell-matrix adhesion" EXACT [] +synonym: "up-regulation of cell-matrix adhesion" EXACT [] +synonym: "upregulation of cell-matrix adhesion" EXACT [] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +is_a: GO:0010811 ! positive regulation of cell-substrate adhesion +relationship: positively_regulates GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0001955 +name: blood vessel maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0001956 +name: positive regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] +synonym: "activation of neurotransmitter secretion" NARROW [] +synonym: "stimulation of neurotransmitter secretion" NARROW [] +synonym: "up regulation of neurotransmitter secretion" EXACT [] +synonym: "up-regulation of neurotransmitter secretion" EXACT [] +synonym: "upregulation of neurotransmitter secretion" EXACT [] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:0051590 ! positive regulation of neurotransmitter transport +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0001957 +name: intramembranous ossification +namespace: biological_process +def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] +comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. +synonym: "dermal ossification" NARROW [GO_REF:0000034] +synonym: "intramembranous bone ossification" RELATED [GOC:cjm] +xref: Wikipedia:Intramembranous_ossification +is_a: GO:0036072 ! direct ossification + +[Term] +id: GO:0001958 +name: endochondral ossification +namespace: biological_process +def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437] +xref: Wikipedia:Endochondral_ossification +is_a: GO:0036075 ! replacement ossification +relationship: part_of GO:0060350 ! endochondral bone morphogenesis + +[Term] +id: GO:0001959 +name: regulation of cytokine-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] +synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of cytokine mediated signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0060759 ! regulation of response to cytokine stimulus +relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001960 +name: negative regulation of cytokine-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] +synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] +synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] +synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060761 ! negative regulation of response to cytokine stimulus +relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001961 +name: positive regulation of cytokine-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] +synonym: "activation of cytokine mediated signaling pathway" NARROW [] +synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] +synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] +synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] +synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0060760 ! positive regulation of response to cytokine stimulus +relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0001962 +name: alpha-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427] +synonym: "isoglobotriaosylceramide synthase" NARROW [] +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0001963 +name: synaptic transmission, dopaminergic +namespace: biological_process +def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] +synonym: "dopaminergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0001964 +name: startle response +namespace: biological_process +def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] +xref: Wikipedia:Startle_reaction +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0001965 +name: G-protein alpha-subunit binding +namespace: molecular_function +def: "Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] +synonym: "G-alpha protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001966 +name: thigmotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] +synonym: "stereotaxis" EXACT [] +synonym: "taxis in response to mechanical stimulus" BROAD [] +synonym: "taxis in response to touch stimulus" EXACT [] +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0001967 +name: suckling behavior +namespace: biological_process +def: "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr] +synonym: "nursing behavior" EXACT [] +is_a: GO:0007631 ! feeding behavior + +[Term] +id: GO:0001968 +name: fibronectin binding +namespace: molecular_function +def: "Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] +subset: goslim_chembl +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0001969 +name: regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +synonym: "regulation of activation of MAC" EXACT [GOC:mah] +synonym: "regulation of activation of TCC" NARROW [GOC:mah] +synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] +synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] +synonym: "regulation of MAC assembly" EXACT [GOC:rl] +synonym: "regulation of MAC formation" EXACT [GOC:rl] +synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] +synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] +is_a: GO:0030449 ! regulation of complement activation +relationship: regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001970 +name: positive regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +synonym: "activation of activation of membrane attack complex" NARROW [] +synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] +synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] +synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] +synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] +synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] +synonym: "positive regulation of MAC formation" EXACT [GOC:rl] +synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] +synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] +synonym: "stimulation of activation of membrane attack complex" NARROW [] +synonym: "up regulation of activation of membrane attack complex" EXACT [] +synonym: "up-regulation of activation of membrane attack complex" EXACT [] +synonym: "upregulation of activation of membrane attack complex" EXACT [] +is_a: GO:0001969 ! regulation of activation of membrane attack complex +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001971 +name: negative regulation of activation of membrane attack complex +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] +synonym: "down regulation of activation of membrane attack complex" EXACT [] +synonym: "down-regulation of activation of membrane attack complex" EXACT [] +synonym: "downregulation of activation of membrane attack complex" EXACT [] +synonym: "inhibition of activation of membrane attack complex" NARROW [] +synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] +synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] +synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] +synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] +synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] +synonym: "negative regulation of MAC formation" EXACT [GOC:rl] +synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] +synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] +is_a: GO:0001969 ! regulation of activation of membrane attack complex +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex + +[Term] +id: GO:0001972 +name: retinoic acid binding +namespace: molecular_function +def: "Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] +is_a: GO:0005501 ! retinoid binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0001973 +name: G protein-coupled adenosine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph] +synonym: "adenosine receptor signaling pathway" RELATED [] +synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289] +synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] +synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289] +is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway + +[Term] +id: GO:0001974 +name: blood vessel remodeling +namespace: biological_process +def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] +is_a: GO:0048771 ! tissue remodeling + +[Term] +id: GO:0001975 +name: response to amphetamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:dph, GOC:ef] +is_a: GO:0014075 ! response to amine + +[Term] +id: GO:0001976 +name: nervous system process involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure regulation by neurological process" EXACT [] +synonym: "fast control of arterial pressure" RELATED [] +synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "neurological system process involved in regulation of systemic arterial blood pressure" EXACT [] +is_a: GO:0050877 ! nervous system process +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0001977 +name: renal system process involved in regulation of blood volume +namespace: biological_process +def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] +synonym: "renal blood volume control of blood pressure" RELATED [] +synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] +is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0001978 +name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +namespace: biological_process +def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949] +synonym: "baroreceptor feedback control of blood pressure" RELATED [] +synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X] +synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0001979 +name: regulation of systemic arterial blood pressure by chemoreceptor signaling +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949] +synonym: "chemoreceptor control of blood pressure" RELATED [] +synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0001980 +name: regulation of systemic arterial blood pressure by ischemic conditions +namespace: biological_process +def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] +synonym: "CNS ischemic response" RELATED [ISBN:0721643949] +synonym: "ischemic control of blood pressure" RELATED [] +synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0001981 +name: baroreceptor detection of arterial stretch +namespace: biological_process +def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback + +[Term] +id: GO:0001982 +name: baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] +is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0001983 +name: baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] +is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0001984 +name: artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949] +synonym: "vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure" EXACT [] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001985 +name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949] +synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] +synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] +synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] +is_a: GO:0010459 ! negative regulation of heart rate +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001986 +name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure +namespace: biological_process +def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] +synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] +is_a: GO:0045822 ! negative regulation of heart contraction +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0001987 +name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001988 +name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] +synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] +synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] +synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] +synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001989 +name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] +synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] +synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] +synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] +is_a: GO:0045823 ! positive regulation of heart contraction +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0001990 +name: regulation of systemic arterial blood pressure by hormone +namespace: biological_process +def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure regulation by hormone" EXACT [] +synonym: "hormonal control of blood pressure" RELATED [] +synonym: "hormonal regulation of blood pressure" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +is_a: GO:0050886 ! endocrine process + +[Term] +id: GO:0001991 +name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin +namespace: biological_process +def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949] +synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] +synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] +synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] +synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] +synonym: "renin-angiotensin blood pressure control" RELATED [] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0001992 +name: regulation of systemic arterial blood pressure by vasopressin +namespace: biological_process +def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure regulation by vasopressin" EXACT [] +synonym: "vasopressin control of blood pressure" RELATED [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0001993 +name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949] +synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] +synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] +synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal + +[Term] +id: GO:0001994 +name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] +synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] +synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] +synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine + +[Term] +id: GO:0001995 +name: norepinephrine-epinephrine catabolic process in blood stream +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] +synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] +is_a: GO:0042419 ! epinephrine catabolic process +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0001996 +name: positive regulation of heart rate by epinephrine-norepinephrine +namespace: biological_process +def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] +synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] +synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] +synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] +synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] +synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] +synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] +synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine + +[Term] +id: GO:0001997 +name: positive regulation of the force of heart contraction by epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] +synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] +synonym: "increased inotropy by epinephrine-norepinephrine" RELATED [] +synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] +synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine + +[Term] +id: GO:0001998 +name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, GOC:pr, ISBN:0721643949] +synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] +synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] +synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] +synonym: "angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure" EXACT [] +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0002034 ! maintenance of blood vessel diameter homeostasis by renin-angiotensin + +[Term] +id: GO:0001999 +name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure +namespace: biological_process +def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] +synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] +is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin + +[Term] +id: GO:0002000 +name: detection of renal blood flow +namespace: biological_process +def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949] +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + +[Term] +id: GO:0002001 +name: renin secretion into blood stream +namespace: biological_process +def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949] +synonym: "renin release into blood stream" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0023061 ! signal release +relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure + +[Term] +id: GO:0002002 +name: regulation of angiotensin levels in blood +namespace: biological_process +def: "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation." [GOC:rl, PMID:21951628, Wikipedia:Angiotensin] +synonym: "control of angiotensin levels in blood" RELATED [] +synonym: "control of blood angiotensin level" RELATED [] +synonym: "regulation of blood angiotensin level" EXACT [] +is_a: GO:0010817 ! regulation of hormone levels +relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin + +[Term] +id: GO:0002003 +name: angiotensin maturation +namespace: biological_process +alt_id: GO:0002005 +def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood." [ISBN:0721643949] +synonym: "angiotensin catabolic process in blood" NARROW [] +is_a: GO:0016486 ! peptide hormone processing +relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood + +[Term] +id: GO:0002004 +name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure +namespace: biological_process +def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949] +synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] +synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] +is_a: GO:0030103 ! vasopressin secretion +relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin + +[Term] +id: GO:0002006 +name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control +namespace: biological_process +def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] +synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin + +[Term] +id: GO:0002007 +name: detection of hypoxic conditions in blood by chemoreceptor signaling +namespace: biological_process +def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] +synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0009593 ! detection of chemical stimulus +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0002008 +name: excitation of vasomotor center by chemoreceptor signaling +namespace: biological_process +def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] +synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling +relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002009 +name: morphogenesis of an epithelium +namespace: biological_process +def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] +synonym: "epithelium morphogenesis" EXACT [] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0060429 ! epithelium development + +[Term] +id: GO:0002010 +name: excitation of vasomotor center by baroreceptor signaling +namespace: biological_process +def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] +synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0002011 +name: morphogenesis of an epithelial sheet +namespace: biological_process +def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0002012 +name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling + +[Term] +id: GO:0002013 +name: detection of carbon dioxide by vasomotor center +namespace: biological_process +def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949] +is_a: GO:0003031 ! detection of carbon dioxide +relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions + +[Term] +id: GO:0002014 +name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949] +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure +is_a: GO:0042310 ! vasoconstriction +relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions + +[Term] +id: GO:0002015 +name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback +namespace: biological_process +def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] +synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "atrial control of blood pressure" RELATED [] +synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] +synonym: "atrial reflex" RELATED [GOC:dph] +is_a: GO:0003015 ! heart process +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0002016 +name: regulation of blood volume by renin-angiotensin +namespace: biological_process +def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] +synonym: "renin-angiotensin control of body fluid levels" RELATED [] +synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0002017 +name: regulation of blood volume by renal aldosterone +namespace: biological_process +def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949] +synonym: "aldosterone mediated control of body fluids" RELATED [] +synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] +synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001977 ! renal system process involved in regulation of blood volume +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0002018 +name: renin-angiotensin regulation of aldosterone production +namespace: biological_process +def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949] +synonym: "renin-angiotensin control of aldosterone production" RELATED [] +is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure +is_a: GO:2000858 ! regulation of aldosterone secretion +relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002019 +name: regulation of renal output by angiotensin +namespace: biological_process +def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] +synonym: "angiotensin mediated control of renal output" RELATED [] +synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002020 +name: protease binding +namespace: molecular_function +def: "Binding to a protease or a peptidase." [GOC:hjd] +xref: Reactome:R-HSA-1297354 "Acrosin Cleavage" +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0002021 +name: response to dietary excess +namespace: biological_process +def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0002022 +name: detection of dietary excess +namespace: biological_process +def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655] +is_a: GO:0050877 ! nervous system process +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002023 +name: reduction of food intake in response to dietary excess +namespace: biological_process +def: "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200] +is_a: GO:0042755 ! eating behavior +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002024 +name: diet induced thermogenesis +namespace: biological_process +def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] +is_a: GO:1990845 ! adaptive thermogenesis +relationship: part_of GO:0002021 ! response to dietary excess + +[Term] +id: GO:0002025 +name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] +synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] +synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] +synonym: "vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure" EXACT [] +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0002026 +name: regulation of the force of heart contraction +namespace: biological_process +def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] +synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] +synonym: "heart inotropy" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0002027 +name: regulation of heart rate +namespace: biological_process +def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] +synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of heart contraction rate" EXACT [] +synonym: "regulation of rate of heart contraction" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0002028 +name: regulation of sodium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] +synonym: "regulation of Na+ transport" EXACT [] +synonym: "regulation of sodium transport" EXACT [] +is_a: GO:0010959 ! regulation of metal ion transport +relationship: regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0002029 +name: desensitization of G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway." [PMID:8396717] +synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] +is_a: GO:0022401 ! negative adaptation of signaling pathway +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway + +[Term] +id: GO:0002030 +name: inhibitory G protein-coupled receptor phosphorylation +namespace: biological_process +def: "The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] +synonym: "inhibitory G-protein coupled receptor phosphorylation" EXACT [] +is_a: GO:0006468 ! protein phosphorylation +relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway + +[Term] +id: GO:0002031 +name: G protein-coupled receptor internalization +namespace: biological_process +def: "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle." [PMID:8396717] +synonym: "G-protein coupled receptor internalization" EXACT [] +is_a: GO:0031623 ! receptor internalization +relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway + +[Term] +id: GO:0002032 +name: desensitization of G protein-coupled receptor signaling pathway by arrestin +namespace: biological_process +def: "The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] +synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "desensitization of G-protein coupled receptor protein signaling pathway by arrestin" EXACT [] +is_a: GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway +is_a: GO:0032091 ! negative regulation of protein binding + +[Term] +id: GO:0002033 +name: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that increases the diameter of a blood vessel via the renin-angiotensin system." [GOC:pr, ISBN:0323031951, PMID:10425188] +synonym: "vasodilation by angiotensin involved in regulation of systemic arterial blood pressure" EXACT [] +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0002034 ! maintenance of blood vessel diameter homeostasis by renin-angiotensin + +[Term] +id: GO:0002034 +name: maintenance of blood vessel diameter homeostasis by renin-angiotensin +namespace: biological_process +def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:pr, GOC:tb] +synonym: "regulation of blood vessel diameter by renin-angiotensin" EXACT [] +synonym: "regulation of blood vessel size by renin-angiotensin" BROAD [] +synonym: "renin-angiotensin regulation of blood vessel size" BROAD [GOC:dph, GOC:tb] +is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin +is_a: GO:0097746 ! blood vessel diameter maintenance + +[Term] +id: GO:0002035 +name: brain renin-angiotensin system +namespace: biological_process +def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin + +[Term] +id: GO:0002036 +name: regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900920 +def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "regulation of L-glutamate import" BROAD [] +synonym: "regulation of L-glutamate transport" BROAD [] +synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane + +[Term] +id: GO:0002037 +name: negative regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900921 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "down regulation of L-glutamate transport" BROAD [] +synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-glutamate transport" BROAD [] +synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamate transport" BROAD [] +synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] +synonym: "inhibition of L-glutamate transport" NARROW [] +synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-glutamate import" BROAD [] +synonym: "negative regulation of L-glutamate transport" BROAD [] +synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "regulation of L-glutamate import" BROAD [] +is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane + +[Term] +id: GO:0002038 +name: positive regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900922 +def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] +synonym: "activation of L-glutamate transport" NARROW [] +synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-glutamate import" BROAD [] +synonym: "positive regulation of L-glutamate transport" BROAD [] +synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "stimulation of L-glutamate transport" NARROW [] +synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamate transport" BROAD [] +synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamate transport" EXACT [] +synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamate transport" BROAD [] +synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] +is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane + +[Term] +id: GO:0002039 +name: p53 binding +namespace: molecular_function +def: "Binding to one of the p53 family of proteins." [GOC:hjd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0002040 +name: sprouting angiogenesis +namespace: biological_process +def: "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation." [PMID:16391003, PMID:23031691] +is_a: GO:0001525 ! angiogenesis + +[Term] +id: GO:0002041 +name: intussusceptive angiogenesis +namespace: biological_process +def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] +is_a: GO:0001525 ! angiogenesis + +[Term] +id: GO:0002042 +name: cell migration involved in sprouting angiogenesis +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] +is_a: GO:0043534 ! blood vessel endothelial cell migration +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0002043 +name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis +namespace: biological_process +def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] +synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001935 ! endothelial cell proliferation +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0002044 +name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis +namespace: biological_process +def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] +is_a: GO:0043534 ! blood vessel endothelial cell migration +relationship: part_of GO:0002041 ! intussusceptive angiogenesis + +[Term] +id: GO:0002045 +name: regulation of cell adhesion involved in intussusceptive angiogenesis +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: part_of GO:0002041 ! intussusceptive angiogenesis + +[Term] +id: GO:0002046 +name: opsin binding +namespace: molecular_function +alt_id: GO:0016030 +def: "Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] +synonym: "metarhodopsin binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0002047 +name: phenazine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] +synonym: "acridizine biosynthesis" RELATED [] +synonym: "acridizine biosynthetic process" RELATED [] +synonym: "azophenylene biosynthesis" RELATED [] +synonym: "azophenylene biosynthetic process" RELATED [] +synonym: "dibenzo-p-diazine biosynthesis" RELATED [] +synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] +synonym: "dibenzopyrazine biosynthesis" RELATED [] +synonym: "dibenzopyrazine biosynthetic process" RELATED [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0002048 +name: pyoverdine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] +synonym: "pyoverdine metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0002049 +name: pyoverdine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] +is_a: GO:0002048 ! pyoverdine metabolic process +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0002050 +name: pyoverdine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] +is_a: GO:0002048 ! pyoverdine metabolic process +is_a: GO:0046215 ! siderophore catabolic process + +[Term] +id: GO:0002051 +name: osteoblast fate commitment +namespace: biological_process +def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0002052 +name: positive regulation of neuroblast proliferation +namespace: biological_process +def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] +synonym: "activation of neuroblast proliferation" NARROW [] +synonym: "stimulation of neuroblast proliferation" NARROW [] +synonym: "up regulation of neuroblast proliferation" EXACT [] +synonym: "up-regulation of neuroblast proliferation" EXACT [] +synonym: "upregulation of neuroblast proliferation" EXACT [] +is_a: GO:0050769 ! positive regulation of neurogenesis +is_a: GO:1902692 ! regulation of neuroblast proliferation +is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0002053 +name: positive regulation of mesenchymal cell proliferation +namespace: biological_process +def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] +synonym: "activation of mesenchymal cell proliferation" NARROW [] +synonym: "stimulation of mesenchymal cell proliferation" NARROW [] +synonym: "up regulation of mesenchymal cell proliferation" EXACT [] +synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] +synonym: "upregulation of mesenchymal cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0002054 +name: nucleobase binding +namespace: molecular_function +def: "Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] +subset: goslim_pir +is_a: GO:0036094 ! small molecule binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0002055 +name: adenine binding +namespace: molecular_function +def: "Binding to adenine, a purine base." [GOC:hjd] +synonym: "6-aminopurine binding" EXACT [] +is_a: GO:0002060 ! purine nucleobase binding + +[Term] +id: GO:0002056 +name: cytosine binding +namespace: molecular_function +def: "Binding to cytosine." [GOC:hjd, GOC:vw] +is_a: GO:0002061 ! pyrimidine nucleobase binding + +[Term] +id: GO:0002057 +name: guanine binding +namespace: molecular_function +def: "Binding to guanine." [GOC:hjd] +is_a: GO:0002060 ! purine nucleobase binding + +[Term] +id: GO:0002058 +name: uracil binding +namespace: molecular_function +def: "Binding to uracil." [GOC:hjd] +is_a: GO:0002061 ! pyrimidine nucleobase binding + +[Term] +id: GO:0002059 +name: thymine binding +namespace: molecular_function +def: "Binding to thymine." [GOC:hjd] +is_a: GO:0002061 ! pyrimidine nucleobase binding + +[Term] +id: GO:0002060 +name: purine nucleobase binding +namespace: molecular_function +def: "Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton." [GOC:hjd] +synonym: "purine base binding" EXACT [GOC:go_curators] +synonym: "purine binding" RELATED [] +is_a: GO:0002054 ! nucleobase binding + +[Term] +id: GO:0002061 +name: pyrimidine nucleobase binding +namespace: molecular_function +def: "Binding to a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [GOC:hjd] +synonym: "1,3-diazine binding" NARROW [] +synonym: "pyrimidine base binding" EXACT [GOC:go_curators] +synonym: "pyrimidine binding" RELATED [] +is_a: GO:0002054 ! nucleobase binding + +[Term] +id: GO:0002062 +name: chondrocyte differentiation +namespace: biological_process +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0002063 +name: chondrocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0002064 +name: epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0002065 +name: columnar/cuboidal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0002066 +name: columnar/cuboidal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0002067 +name: glandular epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0002068 +name: glandular epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002066 ! columnar/cuboidal epithelial cell development +relationship: part_of GO:0002067 ! glandular epithelial cell differentiation + +[Term] +id: GO:0002069 +name: columnar/cuboidal epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] +is_a: GO:0002070 ! epithelial cell maturation +relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development + +[Term] +id: GO:0002070 +name: epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0002064 ! epithelial cell development + +[Term] +id: GO:0002071 +name: glandular epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] +is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation +relationship: part_of GO:0002068 ! glandular epithelial cell development + +[Term] +id: GO:0002072 +name: optic cup morphogenesis involved in camera-type eye development +namespace: biological_process +def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] +synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0060900 ! embryonic camera-type eye formation + +[Term] +id: GO:0002074 +name: extraocular skeletal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] +is_a: GO:0007519 ! skeletal muscle tissue development +is_a: GO:0060538 ! skeletal muscle organ development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0002075 +name: somitomeric trunk muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] +is_a: GO:0060538 ! skeletal muscle organ development + +[Term] +id: GO:0002076 +name: osteoblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0002077 +name: acrosome matrix dispersal +namespace: biological_process +def: "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0002078 +name: membrane fusion involved in acrosome reaction +namespace: biological_process +def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] +synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0061025 ! membrane fusion +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0002079 +name: inner acrosomal membrane +namespace: cellular_component +def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] +comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0002080 +name: acrosomal membrane +namespace: cellular_component +def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0001669 ! acrosomal vesicle + +[Term] +id: GO:0002081 +name: outer acrosomal membrane +namespace: cellular_component +def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] +comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0002082 +name: regulation of oxidative phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] +synonym: "OXPHOS" EXACT [] +is_a: GO:1903578 ! regulation of ATP metabolic process +is_a: GO:1903715 ! regulation of aerobic respiration +relationship: regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0002083 +name: 4-hydroxybenzoate decaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230] +xref: EC:2.5.1.39 +xref: MetaCyc:RXN-9230 +xref: Reactome:R-HSA-2162192 "PHB and all-E-10PrP2 are combined into DHB by COQ2" +xref: RHEA:44564 +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0002084 +name: protein depalmitoylation +namespace: biological_process +def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] +is_a: GO:0035601 ! protein deacylation +is_a: GO:0042159 ! lipoprotein catabolic process +is_a: GO:0098734 ! macromolecule depalmitoylation + +[Term] +id: GO:0002085 +name: inhibition of neuroepithelial cell differentiation +namespace: biological_process +def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] +synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] +synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0048505 ! regulation of timing of cell differentiation +relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation + +[Term] +id: GO:0002086 +name: diaphragm contraction +namespace: biological_process +def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] +is_a: GO:0003011 ! involuntary skeletal muscle contraction +is_a: GO:0003016 ! respiratory system process + +[Term] +id: GO:0002087 +name: regulation of respiratory gaseous exchange by nervous system process +namespace: biological_process +def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] +synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of respiratory gaseous exchange by neurological system process" EXACT [] +is_a: GO:0044065 ! regulation of respiratory system process +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0002088 +name: lens development in camera-type eye +namespace: biological_process +def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] +synonym: "lens development" EXACT [] +synonym: "lens development in camera-style eye" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0002089 +name: lens morphogenesis in camera-type eye +namespace: biological_process +def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] +synonym: "lens morphogenesis" EXACT [] +synonym: "lens morphogenesis in camera-style eye" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0002088 ! lens development in camera-type eye +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0002090 +name: regulation of receptor internalization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002091 +name: negative regulation of receptor internalization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] +synonym: "down regulation of receptor internalization" EXACT [] +synonym: "down-regulation of receptor internalization" EXACT [] +synonym: "downregulation of receptor internalization" EXACT [] +synonym: "inhibition of receptor internalization" NARROW [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis +relationship: negatively_regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002092 +name: positive regulation of receptor internalization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] +synonym: "activation of receptor internalization" NARROW [] +synonym: "stimulation of receptor internalization" NARROW [] +synonym: "up regulation of receptor internalization" EXACT [] +synonym: "up-regulation of receptor internalization" EXACT [] +synonym: "upregulation of receptor internalization" EXACT [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis +relationship: positively_regulates GO:0031623 ! receptor internalization + +[Term] +id: GO:0002093 +name: auditory receptor cell morphogenesis +namespace: biological_process +def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] +synonym: "hair cell morphogenesis" BROAD [GO:dph] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0060117 ! auditory receptor cell development + +[Term] +id: GO:0002094 +name: polyprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0002095 +name: caveolar macromolecular signaling complex +namespace: cellular_component +def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] +synonym: "caveolar macromolecular signalling complex" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005901 ! caveola + +[Term] +id: GO:0002096 +name: polkadots +namespace: cellular_component +def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] +comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0002097 +name: tRNA wobble base modification +namespace: biological_process +def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0002098 +name: tRNA wobble uridine modification +namespace: biological_process +def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002099 +name: tRNA wobble guanine modification +namespace: biological_process +def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002100 +name: tRNA wobble adenosine to inosine editing +namespace: biological_process +def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification +is_a: GO:0006382 ! adenosine to inosine editing + +[Term] +id: GO:0002101 +name: tRNA wobble cytosine modification +namespace: biological_process +def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002097 ! tRNA wobble base modification + +[Term] +id: GO:0002102 +name: podosome +namespace: cellular_component +def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] +comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. +xref: Wikipedia:Podosome +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0002103 +name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing + +[Term] +id: GO:0002104 +name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002105 +name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002106 +name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) +namespace: biological_process +def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] +is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) + +[Term] +id: GO:0002107 +name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III +namespace: biological_process +def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] +is_a: GO:0000481 ! maturation of 5S rRNA +is_a: GO:0031125 ! rRNA 3'-end processing + +[Term] +id: GO:0002108 +name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0000470 ! maturation of LSU-rRNA + +[Term] +id: GO:0002109 +name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] +is_a: GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:0002110 +name: cotranscriptional mitochondrial rRNA nucleotide insertion +namespace: biological_process +def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0070705 ! RNA nucleotide insertion + +[Term] +id: GO:0002111 +name: BRCA2-BRAF35 complex +namespace: cellular_component +def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0002112 +name: interleukin-33 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-33 receptor." [GOC:hjd] +synonym: "IL-33" NARROW [GOC:mah] +synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0002113 +name: interleukin-33 binding +namespace: molecular_function +def: "Binding to interleukin-33." [GOC:hjd] +synonym: "IL-33 binding" EXACT [GOC:mah] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0002114 +name: interleukin-33 receptor activity +namespace: molecular_function +def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] +synonym: "IL-33 receptor activity" EXACT [GOC:mah] +synonym: "IL-33R" EXACT [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0002115 +name: store-operated calcium entry +namespace: biological_process +def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] +comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. +synonym: "calcium ion import" BROAD [] +synonym: "capacitative calcium entry" EXACT [] +synonym: "SOCE" EXACT [] +synonym: "store-operated calcium import" EXACT [] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0002116 +name: semaphorin receptor complex +namespace: cellular_component +def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] +synonym: "plexin-neurophilin complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0002117 +name: amphibian larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, PMID:27143402] +is_a: GO:0002164 ! larval development + +[Term] +id: GO:0002118 +name: aggressive behavior +namespace: biological_process +def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] +synonym: "aggression" EXACT [] +xref: Wikipedia:Aggression +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0002119 +name: nematode larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] +is_a: GO:0002164 ! larval development + +[Term] +id: GO:0002120 +name: obsolete predatory behavior +namespace: biological_process +def: "OBSOLETE. Aggressive behavior involving attack on prey by a predator." [GOC:hjd] +comment: This term was obsoleted because it is outside the scope of GO. +synonym: "predatory aggression" EXACT [] +synonym: "predatory aggressive behavior" EXACT [] +is_obsolete: true + +[Term] +id: GO:0002121 +name: inter-male aggressive behavior +namespace: biological_process +def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] +synonym: "inter-male aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002122 +name: fear-induced aggressive behavior +namespace: biological_process +def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] +synonym: "fear-induced aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002123 +name: irritable aggressive behavior +namespace: biological_process +def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] +synonym: "irritable aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002124 +name: territorial aggressive behavior +namespace: biological_process +def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] +synonym: "territorial aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002125 +name: maternal aggressive behavior +namespace: biological_process +def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] +comment: Paternal aggression also exists. Serves to protect the offspring from intruders. +synonym: "maternal aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002126 +name: instrumental aggressive behavior +namespace: biological_process +def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] +synonym: "instrumental aggression" EXACT [] +is_a: GO:0002118 ! aggressive behavior + +[Term] +id: GO:0002127 +name: tRNA wobble base cytosine methylation +namespace: biological_process +def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] +synonym: "wobble position m5C biosynthesis" EXACT [] +is_a: GO:0002101 ! tRNA wobble cytosine modification +is_a: GO:0002946 ! tRNA C5-cytosine methylation + +[Term] +id: GO:0002128 +name: tRNA nucleoside ribose methylation +namespace: biological_process +def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0002129 +name: wobble position guanine ribose methylation +namespace: biological_process +def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002130 ! wobble position ribose methylation +is_a: GO:0002938 ! tRNA guanine ribose methylation + +[Term] +id: GO:0002130 +name: wobble position ribose methylation +namespace: biological_process +def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002128 ! tRNA nucleoside ribose methylation + +[Term] +id: GO:0002131 +name: wobble position cytosine ribose methylation +namespace: biological_process +def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002130 ! wobble position ribose methylation + +[Term] +id: GO:0002132 +name: wobble position uridine ribose methylation +namespace: biological_process +def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0002130 ! wobble position ribose methylation + +[Term] +id: GO:0002133 +name: polycystin complex +namespace: cellular_component +def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] +comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0002134 +name: UTP binding +namespace: molecular_function +def: "Binding to UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732] +is_a: GO:0032557 ! pyrimidine ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0002135 +name: CTP binding +namespace: molecular_function +def: "Binding to CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607] +is_a: GO:0032557 ! pyrimidine ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0002136 +name: tRNA wobble base lysidine biosynthesis +namespace: biological_process +def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] +comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. +is_a: GO:0002101 ! tRNA wobble cytosine modification + +[Term] +id: GO:0002138 +name: retinoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] +synonym: "retinoic acid anabolic process" EXACT [] +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0042573 ! retinoic acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0002139 +name: stereocilia coupling link +namespace: cellular_component +def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032421 ! stereocilium bundle + +[Term] +id: GO:0002140 +name: stereocilia tip link +namespace: cellular_component +def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] +is_a: GO:0002139 ! stereocilia coupling link + +[Term] +id: GO:0002141 +name: stereocilia ankle link +namespace: cellular_component +def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] +is_a: GO:0002139 ! stereocilia coupling link + +[Term] +id: GO:0002142 +name: stereocilia ankle link complex +namespace: cellular_component +def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0002141 ! stereocilia ankle link + +[Term] +id: GO:0002143 +name: tRNA wobble position uridine thiolation +namespace: biological_process +def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] +comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. +synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] +synonym: "wobble position s2U biosynthesis" EXACT [] +is_a: GO:0002098 ! tRNA wobble uridine modification +is_a: GO:0034227 ! tRNA thio-modification + +[Term] +id: GO:0002144 +name: cytosolic tRNA wobble base thiouridylase complex +namespace: cellular_component +def: "A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets." [PMID:17062623, PMID:18391219] +synonym: "Cut1-Cut2 complex" NARROW [] +synonym: "tRNA thiouridylase" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0002145 +name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543] +synonym: "HMP-PP diphosphatase" EXACT [] +synonym: "HMP-PP pyrophosphatase" EXACT [] +xref: MetaCyc:RXN0-3543 +xref: RHEA:27914 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0002146 +name: obsolete steroid hormone receptor import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0006606 +consider: GO:0042306 + +[Term] +id: GO:0002147 +name: obsolete glucocorticoid receptor import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0042306 + +[Term] +id: GO:0002148 +name: hypochlorous acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] +synonym: "HClO metabolic process" EXACT [] +synonym: "HOCl metabolic process" EXACT [] +synonym: "hypochlorite metabolic process" RELATED [] +synonym: "hypochlorous acid metabolism" EXACT [] +is_a: GO:0043436 ! oxoacid metabolic process +is_a: GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:0002149 +name: hypochlorous acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] +comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. +synonym: "HClO biosynthetic process" EXACT [] +synonym: "HOCl biosynthetic process" EXACT [] +synonym: "hypochlorite biosynthetic process" RELATED [] +synonym: "hypochlorous acid biosynthesis" EXACT [] +is_a: GO:0002148 ! hypochlorous acid metabolic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:1903409 ! reactive oxygen species biosynthetic process + +[Term] +id: GO:0002150 +name: hypochlorous acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] +synonym: "HClO catabolic process" EXACT [] +synonym: "HOCl catabolic process" EXACT [] +synonym: "hypochlorite catabolic process" RELATED [] +synonym: "hypochlorous acid catabolism" EXACT [] +is_a: GO:0002148 ! hypochlorous acid metabolic process +is_a: GO:0044282 ! small molecule catabolic process + +[Term] +id: GO:0002151 +name: G-quadruplex RNA binding +namespace: molecular_function +def: "Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] +comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. +synonym: "G quadruplex binding" EXACT [GOC:mah] +synonym: "G quartet binding" BROAD [GOC:hjd] +synonym: "G quartet RNA binding" EXACT [GOC:hjd] +synonym: "G-quartet binding" BROAD [GOC:mah] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0002152 +name: bile acid conjugation +namespace: biological_process +def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] +comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). +is_a: GO:0008206 ! bile acid metabolic process + +[Term] +id: GO:0002153 +name: steroid receptor RNA activator RNA binding +namespace: molecular_function +def: "Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993] +comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). +synonym: "SRA binding" EXACT [] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0002154 +name: thyroid hormone mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] +synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0002155 +name: regulation of thyroid hormone mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] +synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway + +[Term] +id: GO:0002156 +name: negative regulation of thyroid hormone mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] +synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway + +[Term] +id: GO:0002157 +name: positive regulation of thyroid hormone mediated signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] +synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway + +[Term] +id: GO:0002158 +name: osteoclast proliferation +namespace: biological_process +def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] +is_a: GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0002159 +name: desmosome assembly +namespace: biological_process +def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] +comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. +is_a: GO:0002934 ! desmosome organization +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0002160 +name: desmosome maintenance +namespace: biological_process +def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] +comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. +is_a: GO:0002934 ! desmosome organization +is_a: GO:0045217 ! cell-cell junction maintenance + +[Term] +id: GO:0002161 +name: aminoacyl-tRNA editing activity +namespace: molecular_function +def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] +synonym: "amino acid proofreading activity" RELATED [] +synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] +is_a: GO:0052689 ! carboxylic ester hydrolase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0002162 +name: dystroglycan binding +namespace: molecular_function +alt_id: GO:0002163 +alt_id: GO:0002166 +def: "Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] +synonym: "alpha-dystroglycan binding" NARROW [] +synonym: "beta-dystroglycan binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0002164 +name: larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] +is_a: GO:0007275 ! multicellular organism development +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0002165 +name: instar larval or pupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] +is_a: GO:0007275 ! multicellular organism development +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0002167 +name: VRK3/VHR/ERK complex +namespace: cellular_component +def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0002168 +name: instar larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0002164 ! larval development +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0002169 +name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial +namespace: cellular_component +def: "A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, PMID:15868465, PMID:17360195, PMID:22869039] +synonym: "mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme" EXACT [PMID:22869039] +synonym: "mitochondrial MCCC complex" EXACT [GOC:bf] +synonym: "mitochondrial methylcrotonoyl-CoA carboxylase complex" EXACT [GOC:bf] +is_a: GO:0098798 ! mitochondrial protein-containing complex +is_a: GO:1905202 ! methylcrotonoyl-CoA carboxylase complex + +[Term] +id: GO:0002170 +name: high-affinity IgA receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] +synonym: "high affinity IgA receptor activity" EXACT [] +is_a: GO:0019766 ! IgA receptor activity + +[Term] +id: GO:0002171 +name: low-affinity IgA receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] +synonym: "low affinity IgA receptor activity" EXACT [] +is_a: GO:0019766 ! IgA receptor activity + +[Term] +id: GO:0002172 +name: high-affinity IgM receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] +synonym: "high affinity IgM receptor activity" EXACT [] +is_a: GO:0001793 ! IgM receptor activity + +[Term] +id: GO:0002173 +name: low-affinity IgM receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] +synonym: "low affinity IgM receptor activity" EXACT [] +is_a: GO:0001793 ! IgM receptor activity + +[Term] +id: GO:0002174 +name: mammary stem cell proliferation +namespace: biological_process +def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0002175 +name: protein localization to paranode region of axon +namespace: biological_process +def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321] +synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0099612 ! protein localization to axon + +[Term] +id: GO:0002176 +name: male germ cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] +is_a: GO:0036093 ! germ cell proliferation + +[Term] +id: GO:0002177 +name: manchette +namespace: cellular_component +def: "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments." [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0002178 +name: palmitoyltransferase complex +namespace: cellular_component +def: "A protein complex with palmitoyltransferase activity." [GOC:hjd] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0002179 +name: homodimeric serine palmitoyltransferase complex +namespace: cellular_component +def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd] +comment: This complex occurs primarily in bacteria. +is_a: GO:0017059 ! serine C-palmitoyltransferase complex + +[Term] +id: GO:0002180 +name: 5-lipoxygenase complex +namespace: cellular_component +def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0031965 ! nuclear membrane + +[Term] +id: GO:0002181 +name: cytoplasmic translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] +comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +is_a: GO:0006412 ! translation + +[Term] +id: GO:0002182 +name: cytoplasmic translational elongation +namespace: biological_process +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] +is_a: GO:0006414 ! translational elongation +relationship: part_of GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:0002183 +name: cytoplasmic translational initiation +namespace: biological_process +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] +is_a: GO:0006413 ! translational initiation +relationship: part_of GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:0002184 +name: cytoplasmic translational termination +namespace: biological_process +def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] +is_a: GO:0006415 ! translational termination +relationship: part_of GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:0002185 +name: creatine kinase complex +namespace: cellular_component +def: "A protein complex having creatine kinase activity." [GOC:hjd] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:0002186 +name: cytosolic creatine kinase complex +namespace: cellular_component +def: "A dimeric protein complex having creatine kinase activity." [PMID:173175] +is_a: GO:0002185 ! creatine kinase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0002187 +name: mitochondrial creatine kinase complex +namespace: cellular_component +def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486] +is_a: GO:0002185 ! creatine kinase complex +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0002188 +name: translation reinitiation +namespace: biological_process +def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792] +is_a: GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:0002189 +name: ribose phosphate diphosphokinase complex +namespace: cellular_component +def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095] +comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits. +synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095] +synonym: "PRPP synthetase complex" EXACT [PMID:9348095] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:0002190 +name: cap-independent translational initiation +namespace: biological_process +def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation." [PMID:17284590] +is_a: GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:0002191 +name: cap-dependent translational initiation +namespace: biological_process +def: "The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130] +is_a: GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:0002192 +name: IRES-dependent translational initiation of linear mRNA +namespace: biological_process +def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [PMID:17284590] +is_a: GO:0110017 ! cap-independent translational initiation of linear mRNA + +[Term] +id: GO:0002193 +name: MAML1-RBP-Jkappa- ICN1 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869] +synonym: "MAML1-CSL-ICN1" EXACT [] +synonym: "MAML1-CSL-Notch1 complex" EXACT [] +synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0002194 +name: hepatocyte cell migration +namespace: biological_process +def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0002195 +name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis +namespace: biological_process +def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729] +comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli. +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0002196 +name: Ser-tRNA(Ala) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375] +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0002197 +name: xanthine dehydrogenase complex +namespace: cellular_component +def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0002198 +name: obsolete S/G2 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "S/G2 transition of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0002199 +name: zona pellucida receptor complex +namespace: cellular_component +def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] +synonym: "sperm protein complex I" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0002200 +name: somatic diversification of immune receptors +namespace: biological_process +def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] +comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0002201 +name: somatic diversification of DSCAM-based immune receptors +namespace: biological_process +def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174] +comment: Note that this type of immune receptor may not be limited to insects. +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002202 +name: somatic diversification of variable lymphocyte receptors of jawless fish +namespace: biological_process +def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579] +comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002203 +name: proteolysis by cytosolic proteases associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] +comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002204 +name: somatic recombination of immunoglobulin genes involved in immune response +namespace: biological_process +def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] +synonym: "somatic recombination of antibody genes during immune response" RELATED [] +synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] +is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002205 +name: somatic hypermutation of immunoglobulin genes involved in immune response +namespace: biological_process +def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701] +synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] +synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] +is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response +is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes +relationship: part_of GO:0002344 ! B cell affinity maturation + +[Term] +id: GO:0002206 +name: gene conversion of immunoglobulin genes +namespace: biological_process +def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] +synonym: "gene conversion of antibody genes" EXACT [] +is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion +is_a: GO:0016445 ! somatic diversification of immunoglobulins +is_a: GO:0035822 ! gene conversion + +[Term] +id: GO:0002207 +name: gene conversion of immunoglobulin genes involved in immune response +namespace: biological_process +def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] +synonym: "gene conversion of antibody genes during immune response" RELATED [] +synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] +is_a: GO:0002206 ! gene conversion of immunoglobulin genes +is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response + +[Term] +id: GO:0002208 +name: somatic diversification of immunoglobulins involved in immune response +namespace: biological_process +def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] +synonym: "somatic diversification of antibodies during immune response" RELATED [] +synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] +is_a: GO:0016445 ! somatic diversification of immunoglobulins +relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response + +[Term] +id: GO:0002209 +name: behavioral defense response +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add] +synonym: "behavioural defense response" EXACT [] +is_a: GO:0006952 ! defense response +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0002210 +name: behavioral response to wounding +namespace: biological_process +def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add] +synonym: "behavioural response to wounding" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0002211 +name: behavioral defense response to insect +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] +synonym: "behavioural defense response to insect" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0002213 ! defense response to insect + +[Term] +id: GO:0002212 +name: behavioral defense response to nematode +namespace: biological_process +def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] +synonym: "behavioural defense response to nematode" EXACT [] +is_a: GO:0002209 ! behavioral defense response +is_a: GO:0002215 ! defense response to nematode + +[Term] +id: GO:0002213 +name: defense response to insect +namespace: biological_process +alt_id: GO:0002214 +def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] +synonym: "physiological defense response to insect" EXACT [] +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0002215 +name: defense response to nematode +namespace: biological_process +alt_id: GO:0002216 +def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] +synonym: "physiological defense response to nematode" EXACT [] +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0002218 +name: activation of innate immune response +namespace: biological_process +alt_id: GO:0002219 +def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] +is_a: GO:0002253 ! activation of immune response +is_a: GO:0045089 ! positive regulation of innate immune response + +[Term] +id: GO:0002220 +name: innate immune response activating cell surface receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967] +synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] +synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway +is_a: GO:0002758 ! innate immune response-activating signal transduction + +[Term] +id: GO:0002221 +name: pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] +synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] +synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] +synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] +synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] +is_a: GO:0002764 ! immune response-regulating signaling pathway + +[Term] +id: GO:0002222 +name: stimulatory killer cell immunoglobulin-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] +synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway + +[Term] +id: GO:0002223 +name: stimulatory C-type lectin receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] +synonym: "stimulatory Ly49 family receptor signaling pathway" NARROW [ISBN:0781735149] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway +is_a: GO:1990858 ! cellular response to lectin + +[Term] +id: GO:0002224 +name: toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +comment: Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. +synonym: "TLR signaling pathway" EXACT [ISBN:0781735149] +synonym: "toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002225 +name: positive regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] +synonym: "activation of antimicrobial peptide production" NARROW [] +synonym: "antimicrobial peptide induction" EXACT [] +synonym: "stimulation of antimicrobial peptide production" NARROW [] +synonym: "up regulation of antimicrobial peptide production" EXACT [] +synonym: "up-regulation of antimicrobial peptide production" EXACT [] +synonym: "upregulation of antimicrobial peptide production" EXACT [] +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0002760 ! positive regulation of antimicrobial humoral response +is_a: GO:0002784 ! regulation of antimicrobial peptide production +relationship: positively_regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002227 +name: innate immune response in mucosa +namespace: biological_process +def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] +is_a: GO:0002385 ! mucosal immune response +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0002228 +name: natural killer cell mediated immunity +namespace: biological_process +def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "NK cell mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0002229 +name: defense response to oomycetes +namespace: biological_process +def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] +is_a: GO:0002239 ! response to oomycetes +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0002230 +name: positive regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] +synonym: "activation of antiviral response by host" NARROW [] +synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of antiviral response by host" NARROW [] +synonym: "up regulation of antiviral response by host" EXACT [] +synonym: "up-regulation of antiviral response by host" EXACT [] +synonym: "upregulation of antiviral response by host" EXACT [] +is_a: GO:0050691 ! regulation of defense response to virus by host + +[Term] +id: GO:0002231 +name: detection of oomycetes +namespace: biological_process +def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] +is_a: GO:0002239 ! response to oomycetes +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0002232 +name: leukocyte chemotaxis involved in inflammatory response +namespace: biological_process +def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "immune cell chemotaxis during inflammatory response" RELATED [] +synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] +synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] +is_a: GO:0002523 ! leukocyte migration involved in inflammatory response +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002233 +name: leukocyte chemotaxis involved in immune response +namespace: biological_process +def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] +synonym: "immune cell chemotaxis during immune response" EXACT [] +synonym: "leucocyte chemotaxis during immune response" EXACT [] +is_a: GO:0002522 ! leukocyte migration involved in immune response +is_a: GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002234 +name: detection of endoplasmic reticulum overloading +namespace: biological_process +def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] +synonym: "detection of ER overloading" EXACT [] +is_a: GO:0006983 ! ER overload response +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002235 +name: detection of unfolded protein +namespace: biological_process +def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] +is_a: GO:0006986 ! response to unfolded protein +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0002236 +name: detection of misfolded protein +namespace: biological_process +def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051788 ! response to misfolded protein + +[Term] +id: GO:0002237 +name: response to molecule of bacterial origin +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] +synonym: "response to bacteria associated molecule" EXACT [] +synonym: "response to bacterial associated molecule" EXACT [] +synonym: "response to bacterium associated molecule" EXACT [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0043207 ! response to external biotic stimulus +relationship: part_of GO:0009617 ! response to bacterium + +[Term] +id: GO:0002238 +name: response to molecule of fungal origin +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] +synonym: "response to fungus associated molecule" EXACT [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0043207 ! response to external biotic stimulus +relationship: part_of GO:0009620 ! response to fungus + +[Term] +id: GO:0002239 +name: response to oomycetes +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0002240 +name: response to molecule of oomycetes origin +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] +synonym: "response to oomycetes associated molecule" EXACT [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0043207 ! response to external biotic stimulus +relationship: part_of GO:0002239 ! response to oomycetes + +[Term] +id: GO:0002241 +name: response to parasitic plant +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] +is_a: GO:0009608 ! response to symbiont + +[Term] +id: GO:0002242 +name: defense response to parasitic plant +namespace: biological_process +def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] +is_a: GO:0002241 ! response to parasitic plant +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0002243 +name: detection of parasitic plant +namespace: biological_process +def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] +is_a: GO:0002241 ! response to parasitic plant +is_a: GO:0009602 ! detection of symbiont + +[Term] +id: GO:0002244 +name: hematopoietic progenitor cell differentiation +namespace: biological_process +def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] +synonym: "haematopoietic progenitor cell differentiation" EXACT [] +synonym: "haemopoietic progenitor cell differentiation" EXACT [] +synonym: "hemopoietic progenitor cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0002246 +name: wound healing involved in inflammatory response +namespace: biological_process +def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] +synonym: "healing during inflammatory response" RELATED [GOC:dph] +synonym: "inflammatory response wound healing" RELATED [GOC:dph] +is_a: GO:0042060 ! wound healing +relationship: part_of GO:0090594 ! inflammatory response to wounding + +[Term] +id: GO:0002247 +name: clearance of damaged tissue involved in inflammatory response wound healing +namespace: biological_process +def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] +synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0002246 ! wound healing involved in inflammatory response + +[Term] +id: GO:0002248 +name: connective tissue replacement involved in inflammatory response wound healing +namespace: biological_process +def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] +synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] +synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] +is_a: GO:0097709 ! connective tissue replacement +relationship: part_of GO:0002246 ! wound healing involved in inflammatory response + +[Term] +id: GO:0002249 +name: lymphocyte anergy +namespace: biological_process +def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002250 +name: adaptive immune response +namespace: biological_process +def: "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "acquired immune response" EXACT [ISBN:068340007X] +synonym: "immune memory response" EXACT [GOC:add] +xref: Wikipedia:Adaptive_immune_system +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002251 +name: organ or tissue specific immune response +namespace: biological_process +def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal] +synonym: "immune response in organ or tissue" EXACT [] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002252 +name: immune effector process +namespace: biological_process +def: "Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0002253 +name: activation of immune response +namespace: biological_process +def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002376 ! immune system process +is_a: GO:0050778 ! positive regulation of immune response + +[Term] +id: GO:0002254 +name: kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] +is_a: GO:0002526 ! acute inflammatory response +is_a: GO:0072376 ! protein activation cascade + +[Term] +id: GO:0002255 +name: tissue kallikrein-kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] +synonym: "glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002254 ! kinin cascade + +[Term] +id: GO:0002256 +name: regulation of kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002257 +name: negative regulation of kinin cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] +synonym: "down regulation of kinin cascade" EXACT [] +synonym: "down-regulation of kinin cascade" EXACT [] +synonym: "downregulation of kinin cascade" EXACT [] +synonym: "inhibition of kinin cascade" NARROW [] +is_a: GO:0002256 ! regulation of kinin cascade +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:2000258 ! negative regulation of protein activation cascade +relationship: negatively_regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002258 +name: positive regulation of kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] +synonym: "activation of kinin cascade" NARROW [] +synonym: "stimulation of kinin cascade" NARROW [] +synonym: "up regulation of kinin cascade" EXACT [] +synonym: "up-regulation of kinin cascade" EXACT [] +synonym: "upregulation of kinin cascade" EXACT [] +is_a: GO:0002256 ! regulation of kinin cascade +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:2000259 ! positive regulation of protein activation cascade +relationship: positively_regulates GO:0002254 ! kinin cascade + +[Term] +id: GO:0002259 +name: endothelial cell activation within high endothelial venule involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] +is_a: GO:0002264 ! endothelial cell activation involved in immune response + +[Term] +id: GO:0002260 +name: lymphocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] +is_a: GO:0001776 ! leukocyte homeostasis + +[Term] +id: GO:0002261 +name: mucosal lymphocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0002262 +name: myeloid cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] +is_a: GO:0002376 ! immune system process +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0002263 +name: cell activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0001775 ! cell activation +is_a: GO:0002252 ! immune effector process +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0002264 +name: endothelial cell activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002263 ! cell activation involved in immune response +is_a: GO:0042118 ! endothelial cell activation + +[Term] +id: GO:0002265 +name: astrocyte activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] +synonym: "astrocyte activation during immune response" RELATED [GOC:tb] +is_a: GO:0002263 ! cell activation involved in immune response +is_a: GO:0048143 ! astrocyte activation + +[Term] +id: GO:0002266 +name: follicular dendritic cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0002267 +name: follicular dendritic cell activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] +synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002263 ! cell activation involved in immune response +is_a: GO:0002266 ! follicular dendritic cell activation + +[Term] +id: GO:0002268 +name: follicular dendritic cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] +is_a: GO:0002266 ! follicular dendritic cell activation +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0002269 +name: leukocyte activation involved in inflammatory response +namespace: biological_process +def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "immune cell activation during inflammatory response" RELATED [] +synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] +is_a: GO:0045321 ! leukocyte activation +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002270 +name: plasmacytoid dendritic cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002271 +name: plasmacytoid dendritic cell activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] +synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002270 ! plasmacytoid dendritic cell activation +is_a: GO:0002366 ! leukocyte activation involved in immune response + +[Term] +id: GO:0002272 +name: plasmacytoid dendritic cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] +synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] +is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response +is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation + +[Term] +id: GO:0002273 +name: plasmacytoid dendritic cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] +is_a: GO:0002270 ! plasmacytoid dendritic cell activation +is_a: GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:0002274 +name: myeloid leukocyte activation +namespace: biological_process +def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] +synonym: "myeloid leucocyte activation" EXACT [] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002275 +name: myeloid cell activation involved in immune response +namespace: biological_process +def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002274 ! myeloid leukocyte activation +is_a: GO:0002366 ! leukocyte activation involved in immune response + +[Term] +id: GO:0002276 +name: basophil activation involved in immune response +namespace: biological_process +def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "basophil activation during immune response" RELATED [GOC:tb] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0045575 ! basophil activation + +[Term] +id: GO:0002277 +name: myeloid dendritic cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0001773 ! myeloid dendritic cell activation +is_a: GO:0002275 ! myeloid cell activation involved in immune response + +[Term] +id: GO:0002278 +name: eosinophil activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "eosinophil activation during immune response" RELATED [GOC:tb] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0043307 ! eosinophil activation + +[Term] +id: GO:0002279 +name: mast cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "mast cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0045576 ! mast cell activation + +[Term] +id: GO:0002280 +name: monocyte activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] +synonym: "monocyte activation during immune response" RELATED [GOC:tb] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0042117 ! monocyte activation + +[Term] +id: GO:0002281 +name: macrophage activation involved in immune response +namespace: biological_process +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "macrophage activation during immune response" RELATED [GOC:tb] +synonym: "macrophage polarization involved in immune response" EXACT [] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0042116 ! macrophage activation + +[Term] +id: GO:0002282 +name: microglial cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "microglial cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0001774 ! microglial cell activation +is_a: GO:0002281 ! macrophage activation involved in immune response + +[Term] +id: GO:0002283 +name: neutrophil activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "neutrophil activation during immune response" RELATED [GOC:tb] +is_a: GO:0002275 ! myeloid cell activation involved in immune response +is_a: GO:0042119 ! neutrophil activation + +[Term] +id: GO:0002284 +name: myeloid dendritic cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] +synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] +is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response +is_a: GO:0043011 ! myeloid dendritic cell differentiation + +[Term] +id: GO:0002285 +name: lymphocyte activation involved in immune response +namespace: biological_process +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] +is_a: GO:0002366 ! leukocyte activation involved in immune response +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0002286 +name: T cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "T cell activation during immune response" RELATED [GOC:tb] +synonym: "T lymphocyte activation during immune response" RELATED [] +synonym: "T-cell activation during immune response" RELATED [] +synonym: "T-lymphocyte activation during immune response" RELATED [] +is_a: GO:0002285 ! lymphocyte activation involved in immune response +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0002287 +name: alpha-beta T cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] +synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] +synonym: "alpha-beta T-cell activation during immune response" RELATED [] +synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] +is_a: GO:0002286 ! T cell activation involved in immune response +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0002288 +name: NK T cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] +synonym: "natural killer T lymphocyte activation during immune response" RELATED [] +synonym: "natural killer T-cell activation during immune response" RELATED [] +synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] +synonym: "NK T cell activation during immune response" RELATED [GOC:tb] +synonym: "NK T lymphocyte activation during immune response" RELATED [] +synonym: "NK T-cell activation during immune response" RELATED [] +synonym: "NK T-lymphocyte activation during immune response" RELATED [] +is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response +is_a: GO:0051132 ! NK T cell activation + +[Term] +id: GO:0002289 +name: NK T cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] +synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] +synonym: "natural killer T-cell proliferation during immune response" RELATED [] +synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] +synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] +synonym: "NK T lymphocyte proliferation during immune response" RELATED [] +synonym: "NK T-cell proliferation during immune response" RELATED [] +synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] +is_a: GO:0001866 ! NK T cell proliferation +is_a: GO:0002288 ! NK T cell activation involved in immune response +is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response + +[Term] +id: GO:0002290 +name: gamma-delta T cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] +synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] +synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] +synonym: "gamma-delta T-cell activation during immune response" RELATED [] +synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] +is_a: GO:0002286 ! T cell activation involved in immune response +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0002291 +name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] +is_a: GO:0002286 ! T cell activation involved in immune response + +[Term] +id: GO:0002292 +name: T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T cell development involved in immune response" RELATED [GOC:add] +synonym: "T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "T lymphocyte differentiation during immune response" RELATED [] +synonym: "T-cell differentiation during immune response" RELATED [] +synonym: "T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002286 ! T cell activation involved in immune response +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002293 +name: alpha-beta T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] +synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] +synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] +synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response +is_a: GO:0002292 ! T cell differentiation involved in immune response +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002294 +name: CD4-positive, alpha-beta T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] +synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] +synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] +synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response +is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002295 +name: T-helper cell lineage commitment +namespace: biological_process +def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149] +synonym: "T-helper cell fate commitment" EXACT [] +synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149] +synonym: "Thp lineage commitment" RELATED [ISBN:0781735149] +is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0002296 +name: T-helper 1 cell lineage commitment +namespace: biological_process +def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149] +synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149] +synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149] +synonym: "Th1 fate commitment" EXACT [ISBN:0781735149] +is_a: GO:0002295 ! T-helper cell lineage commitment +relationship: part_of GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0002297 +name: T-helper 2 cell lineage commitment +namespace: biological_process +def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149] +synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149] +synonym: "Th2 fate commitment" EXACT [ISBN:0781735149] +is_a: GO:0002295 ! T-helper cell lineage commitment +relationship: part_of GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0002298 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] +synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] +is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response +is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0002299 +name: alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] +synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002300 +name: CD8-positive, alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] +synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002301 +name: CD4-positive, alpha-beta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] +synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation +is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002302 +name: CD8-positive, alpha-beta T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] +synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] +synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] +synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0002303 +name: gamma-delta T cell differentiation involved in immune response +namespace: biological_process +def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] +synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] +synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] +synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] +synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response +is_a: GO:0002292 ! T cell differentiation involved in immune response +is_a: GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002304 +name: gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] +synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002305 +name: CD8-positive, gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] +synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation + +[Term] +id: GO:0002306 +name: CD4-positive gamma-delta intraepithelial T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] +synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] +synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] +is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation + +[Term] +id: GO:0002307 +name: CD8-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] +synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation +is_a: GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0002308 +name: CD8-positive, alpha-beta cytotoxic T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] +synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation +is_a: GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0002309 +name: T cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] +synonym: "T cell proliferation during immune response" RELATED [GOC:tb] +synonym: "T lymphocyte proliferation during immune response" RELATED [] +synonym: "T-cell proliferation during immune response" RELATED [] +synonym: "T-lymphocyte proliferation during immune response" RELATED [] +is_a: GO:0002286 ! T cell activation involved in immune response +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0002310 +name: alpha-beta T cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] +synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] +synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] +synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] +synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] +is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response +is_a: GO:0002309 ! T cell proliferation involved in immune response +is_a: GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0002311 +name: gamma-delta T cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] +synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] +synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] +synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] +synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] +is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response +is_a: GO:0002309 ! T cell proliferation involved in immune response +is_a: GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0002312 +name: B cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] +synonym: "B cell activation during immune response" RELATED [GOC:tb] +synonym: "B lymphocyte activation during immune response" RELATED [] +synonym: "B-cell activation during immune response" RELATED [] +synonym: "B-lymphocyte activation during immune response" RELATED [] +is_a: GO:0002285 ! lymphocyte activation involved in immune response +is_a: GO:0042113 ! B cell activation + +[Term] +id: GO:0002313 +name: mature B cell differentiation involved in immune response +namespace: biological_process +def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "mature B cell development involved in immune response" RELATED [GOC:add] +synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] +synonym: "mature B lymphocyte differentiation during immune response" RELATED [] +synonym: "mature B-cell differentiation during immune response" RELATED [] +synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002312 ! B cell activation involved in immune response +is_a: GO:0002335 ! mature B cell differentiation + +[Term] +id: GO:0002314 +name: germinal center B cell differentiation +namespace: biological_process +def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "germinal center B cell development" RELATED [GOC:add] +synonym: "germinal center B lymphocyte differentiation" EXACT [] +synonym: "germinal center B-cell differentiation" EXACT [] +synonym: "germinal center B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation involved in immune response + +[Term] +id: GO:0002315 +name: marginal zone B cell differentiation +namespace: biological_process +def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "marginal zone B cell development" RELATED [GOC:add] +synonym: "marginal zone B lymphocyte differentiation" EXACT [] +synonym: "marginal zone B-cell differentiation" EXACT [] +synonym: "marginal zone B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation involved in immune response + +[Term] +id: GO:0002316 +name: follicular B cell differentiation +namespace: biological_process +def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "follicular B cell development" RELATED [GOC:add] +synonym: "follicular B lymphocyte differentiation" EXACT [] +synonym: "follicular B-cell differentiation" EXACT [] +synonym: "follicular B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation involved in immune response + +[Term] +id: GO:0002317 +name: plasma cell differentiation +namespace: biological_process +def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "plasma cell development" RELATED [GOC:add] +is_a: GO:0002313 ! mature B cell differentiation involved in immune response + +[Term] +id: GO:0002318 +name: myeloid progenitor cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] +is_a: GO:0002244 ! hematopoietic progenitor cell differentiation + +[Term] +id: GO:0002319 +name: memory B cell differentiation +namespace: biological_process +def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "memory B cell development" RELATED [GOC:add] +synonym: "memory B lymphocyte differentiation" EXACT [] +synonym: "memory B-cell differentiation" EXACT [] +synonym: "memory B-lymphocyte differentiation" EXACT [] +is_a: GO:0002313 ! mature B cell differentiation involved in immune response +is_a: GO:0090715 ! immunological memory formation process + +[Term] +id: GO:0002320 +name: lymphoid progenitor cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] +is_a: GO:0002244 ! hematopoietic progenitor cell differentiation + +[Term] +id: GO:0002321 +name: natural killer cell progenitor differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:0002322 +name: B cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] +synonym: "B cell proliferation during immune response" RELATED [GOC:tb] +synonym: "B lymphocyte proliferation during immune response" RELATED [] +synonym: "B-cell proliferation during immune response" RELATED [] +synonym: "B-lymphocyte proliferation during immune response" RELATED [] +is_a: GO:0002312 ! B cell activation involved in immune response +is_a: GO:0042100 ! B cell proliferation + +[Term] +id: GO:0002323 +name: natural killer cell activation involved in immune response +namespace: biological_process +def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] +synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] +synonym: "NK cell activation during immune response" RELATED [] +is_a: GO:0002285 ! lymphocyte activation involved in immune response +is_a: GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0002324 +name: natural killer cell proliferation involved in immune response +namespace: biological_process +def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] +synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] +synonym: "NK cell proliferation during immune response" RELATED [] +is_a: GO:0001787 ! natural killer cell proliferation +is_a: GO:0002323 ! natural killer cell activation involved in immune response + +[Term] +id: GO:0002325 +name: natural killer cell differentiation involved in immune response +namespace: biological_process +def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] +synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] +synonym: "NK cell differentiation during immune response" RELATED [] +is_a: GO:0001779 ! natural killer cell differentiation +is_a: GO:0002323 ! natural killer cell activation involved in immune response + +[Term] +id: GO:0002326 +name: B cell lineage commitment +namespace: biological_process +def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149] +synonym: "B lymphocyte lineage commitment" EXACT [] +synonym: "B-cell lineage commitment" EXACT [] +synonym: "B-lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002327 +name: immature B cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "immature B cell development" RELATED [GOC:add] +synonym: "immature B lymphocyte differentiation" EXACT [] +synonym: "immature B-cell differentiation" EXACT [] +synonym: "immature B-lymphocyte differentiation" EXACT [] +is_a: GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002328 +name: pro-B cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149] +synonym: "pro-B cell development" RELATED [GOC:add] +synonym: "pro-B lymphocyte differentiation" EXACT [] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:0002329 +name: pre-B cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "pre-B cell development" RELATED [GOC:add] +synonym: "pre-B lymphocyte differentiation" EXACT [] +is_a: GO:0002327 ! immature B cell differentiation + +[Term] +id: GO:0002330 +name: pre-B cell receptor expression +namespace: biological_process +def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell." [GOC:add, GOC:jal, PMID:15263090, PMID:22949502, PMID:9834086] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0002329 ! pre-B cell differentiation + +[Term] +id: GO:0002331 +name: pre-B cell allelic exclusion +namespace: biological_process +def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149] +synonym: "pre-B lymphocyte allelic exclusion" EXACT [] +is_a: GO:0010468 ! regulation of gene expression +relationship: part_of GO:0002329 ! pre-B cell differentiation + +[Term] +id: GO:0002332 +name: transitional stage B cell differentiation +namespace: biological_process +def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "transitional stage B cell development" RELATED [GOC:add] +synonym: "transitional stage B lymphocyte differentiation" EXACT [] +synonym: "transitional stage B-cell differentiation" EXACT [] +synonym: "transitional stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002327 ! immature B cell differentiation + +[Term] +id: GO:0002333 +name: transitional one stage B cell differentiation +namespace: biological_process +def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T1 stage B cell differentiation" EXACT [] +synonym: "transitional one stage B cell development" RELATED [GOC:add] +synonym: "transitional one stage B lymphocyte differentiation" EXACT [] +synonym: "transitional one stage B-cell differentiation" EXACT [] +synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002332 ! transitional stage B cell differentiation + +[Term] +id: GO:0002334 +name: transitional two stage B cell differentiation +namespace: biological_process +def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T2 stage B cell differentiation" EXACT [] +synonym: "transitional two stage B cell development" RELATED [GOC:add] +synonym: "transitional two stage B lymphocyte differentiation" EXACT [] +synonym: "transitional two stage B-cell differentiation" EXACT [] +synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] +is_a: GO:0002332 ! transitional stage B cell differentiation + +[Term] +id: GO:0002335 +name: mature B cell differentiation +namespace: biological_process +def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "mature B lymphocyte differentiation" EXACT [] +synonym: "mature B-cell differentiation" EXACT [] +synonym: "mature B-lymphocyte differentiation" EXACT [] +synonym: "mature cell development" RELATED [GOC:add] +is_a: GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002336 +name: B-1 B cell lineage commitment +namespace: biological_process +def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149] +synonym: "B-1 B lymphocyte lineage commitment" EXACT [] +synonym: "B-1 B-cell lineage commitment" EXACT [] +synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002326 ! B cell lineage commitment +relationship: part_of GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002337 +name: B-1a B cell differentiation +namespace: biological_process +def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "B-1a B cell development" RELATED [GOC:add] +synonym: "B-1a B lymphocyte differentiation" EXACT [] +synonym: "B-1a B-cell differentiation" EXACT [] +synonym: "B-1a B-lymphocyte differentiation" EXACT [] +is_a: GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002338 +name: B-1b B cell differentiation +namespace: biological_process +def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "B-1b B cell development" RELATED [GOC:add] +synonym: "B-1b B lymphocyte differentiation" EXACT [] +synonym: "B-1b B-cell differentiation" EXACT [] +synonym: "B-1b B-lymphocyte differentiation" EXACT [] +is_a: GO:0001923 ! B-1 B cell differentiation + +[Term] +id: GO:0002339 +name: B cell selection +namespace: biological_process +def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] +synonym: "B lymphocyte selection" EXACT [] +synonym: "B-cell selection" EXACT [] +synonym: "B-lymphocyte selection" EXACT [] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0030183 ! B cell differentiation + +[Term] +id: GO:0002340 +name: central B cell selection +namespace: biological_process +def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte selection" EXACT [] +synonym: "central B-cell selection" EXACT [] +synonym: "central B-lymphocyte selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002341 +name: central B cell anergy +namespace: biological_process +def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte anergy" EXACT [] +synonym: "central B-cell anergy" EXACT [] +synonym: "central B-lymphocyte anergy" EXACT [] +is_a: GO:0002515 ! B cell anergy +relationship: part_of GO:0002340 ! central B cell selection +relationship: part_of GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002342 +name: central B cell deletion +namespace: biological_process +def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis] +synonym: "central B lymphocyte deletion" EXACT [] +synonym: "central B-cell deletion" EXACT [] +synonym: "central B-lymphocyte deletion" EXACT [] +is_a: GO:0002516 ! B cell deletion +relationship: part_of GO:0002340 ! central B cell selection +relationship: part_of GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002343 +name: peripheral B cell selection +namespace: biological_process +def: "Any B cell selection process that occurs in the periphery." [GOC:jal] +synonym: "peripheral B lymphocyte selection" EXACT [] +synonym: "peripheral B-cell selection" EXACT [] +synonym: "peripheral B-lymphocyte selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002344 +name: B cell affinity maturation +namespace: biological_process +def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +synonym: "B lymphocyte affinity maturation" EXACT [] +synonym: "B-cell affinity maturation" EXACT [] +synonym: "B-lymphocyte affinity maturation" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response + +[Term] +id: GO:0002345 +name: peripheral B cell receptor editing +namespace: biological_process +def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] +synonym: "peripheral B lymphocyte receptor editing" EXACT [] +synonym: "peripheral B-cell receptor editing" EXACT [] +synonym: "peripheral B-lymphocyte receptor editing" EXACT [] +is_a: GO:0002452 ! B cell receptor editing + +[Term] +id: GO:0002346 +name: B cell positive selection +namespace: biological_process +def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] +synonym: "B lymphocyte positive selection" EXACT [] +synonym: "B-cell positive selection" EXACT [] +synonym: "B-lymphocyte positive selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002347 +name: response to tumor cell +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002348 +name: central B cell positive selection +namespace: biological_process +def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] +synonym: "central B lymphocyte positive selection" EXACT [] +synonym: "central B-cell positive selection" EXACT [] +synonym: "central B-lymphocyte positive selection" EXACT [] +is_a: GO:0002340 ! central B cell selection +is_a: GO:0002346 ! B cell positive selection + +[Term] +id: GO:0002349 +name: histamine production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] +synonym: "histamine production involved in acute inflammatory response" BROAD [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002350 +name: peripheral B cell positive selection +namespace: biological_process +def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] +synonym: "peripheral B lymphocyte positive selection" EXACT [] +synonym: "peripheral B-cell positive selection" EXACT [] +synonym: "peripheral B-lymphocyte positive selection" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +is_a: GO:0002346 ! B cell positive selection + +[Term] +id: GO:0002351 +name: serotonin production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] +synonym: "serotonin production involved in acute inflammatory response" BROAD [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002352 +name: B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] +synonym: "B lymphocyte negative selection" EXACT [] +synonym: "B-cell negative selection" EXACT [] +synonym: "B-lymphocyte negative selection" EXACT [] +is_a: GO:0002339 ! B cell selection + +[Term] +id: GO:0002353 +name: plasma kallikrein-kinin cascade +namespace: biological_process +def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] +is_a: GO:0002254 ! kinin cascade + +[Term] +id: GO:0002354 +name: central B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] +synonym: "central B lymphocyte negative selection" EXACT [] +synonym: "central B-cell negative selection" EXACT [] +synonym: "central B-lymphocyte negative selection" EXACT [] +is_a: GO:0002340 ! central B cell selection +is_a: GO:0002352 ! B cell negative selection + +[Term] +id: GO:0002355 +name: detection of tumor cell +namespace: biological_process +def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0002356 +name: peripheral B cell negative selection +namespace: biological_process +def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] +synonym: "peripheral B lymphocyte negative selection" EXACT [] +synonym: "peripheral B-cell negative selection" EXACT [] +synonym: "peripheral B-lymphocyte negative selection" EXACT [] +is_a: GO:0002343 ! peripheral B cell selection +is_a: GO:0002352 ! B cell negative selection + +[Term] +id: GO:0002357 +name: defense response to tumor cell +namespace: biological_process +def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0002358 +name: B cell homeostatic proliferation +namespace: biological_process +def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] +synonym: "B lymphocyte homeostatic proliferation" EXACT [] +synonym: "B-cell homeostatic proliferation" EXACT [] +synonym: "B-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042100 ! B cell proliferation +relationship: part_of GO:0042592 ! homeostatic process + +[Term] +id: GO:0002359 +name: B-1 B cell proliferation +namespace: biological_process +def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] +synonym: "B-1 B lymphocyte proliferation" EXACT [] +synonym: "B-1 B-cell proliferation" EXACT [] +synonym: "B-1 B-lymphocyte proliferation" EXACT [] +is_a: GO:0042100 ! B cell proliferation + +[Term] +id: GO:0002360 +name: T cell lineage commitment +namespace: biological_process +def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149] +synonym: "T lymphocyte lineage commitment" EXACT [] +synonym: "T-cell lineage commitment" EXACT [] +synonym: "T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002361 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0002362 +name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment +namespace: biological_process +def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] +synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0002363 +name: alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149] +synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "alpha-beta T-cell lineage commitment" EXACT [] +synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0002364 +name: NK T cell lineage commitment +namespace: biological_process +def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149] +synonym: "natural killer T lymphocyte lineage commitment" EXACT [] +synonym: "natural killer T-cell lineage commitment" EXACT [] +synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] +synonym: "NK T lymphocyte lineage commitment" EXACT [] +synonym: "NK T-cell lineage commitment" EXACT [] +synonym: "NK T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002363 ! alpha-beta T cell lineage commitment +relationship: part_of GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0002365 +name: gamma-delta T cell lineage commitment +namespace: biological_process +def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149] +synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] +synonym: "gamma-delta T-cell lineage commitment" EXACT [] +synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0002366 +name: leukocyte activation involved in immune response +namespace: biological_process +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] +synonym: "immune cell activation during immune response" RELATED [] +synonym: "leucocyte activation during immune response" RELATED [] +synonym: "leukocyte activation during immune response" RELATED [GOC:tb] +is_a: GO:0002263 ! cell activation involved in immune response +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002367 +name: cytokine production involved in immune response +namespace: biological_process +alt_id: GO:0002374 +alt_id: GO:0002375 +def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "cytokine biosynthetic process involved in immune response" NARROW [] +synonym: "cytokine production during immune response" RELATED [GOC:dph] +synonym: "cytokine secretion during immune response" RELATED [GOC:dph] +synonym: "cytokine secretion involved in immune response" RELATED [] +is_a: GO:0001816 ! cytokine production +is_a: GO:0002440 ! production of molecular mediator of immune response +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0002368 +name: B cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "B lymphocyte cytokine production" EXACT [] +synonym: "B-cell cytokine production" EXACT [] +synonym: "B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002367 ! cytokine production involved in immune response +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002369 +name: T cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "T lymphocyte cytokine production" EXACT [] +synonym: "T-cell cytokine production" EXACT [] +synonym: "T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002367 ! cytokine production involved in immune response +is_a: GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002370 +name: natural killer cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "NK cell cytokine production" EXACT [] +is_a: GO:0002228 ! natural killer cell mediated immunity +is_a: GO:0002367 ! cytokine production involved in immune response + +[Term] +id: GO:0002371 +name: dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002367 ! cytokine production involved in immune response +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002372 +name: myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002371 ! dendritic cell cytokine production +is_a: GO:0002444 ! myeloid leukocyte mediated immunity +is_a: GO:0061082 ! myeloid leukocyte cytokine production + +[Term] +id: GO:0002373 +name: plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002376 +name: immune system process +namespace: biological_process +def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add] +comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +xref: Wikipedia:Immune_system +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0002377 +name: immunoglobulin production +namespace: biological_process +alt_id: GO:0002378 +alt_id: GO:0048305 +def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "antibody production" EXACT [] +synonym: "immunoglobulin biosynthetic process" NARROW [] +synonym: "immunoglobulin secretion" NARROW [] +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002381 +name: immunoglobulin production involved in immunoglobulin-mediated immune response +namespace: biological_process +alt_id: GO:0002379 +alt_id: GO:0002380 +def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:9185563] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "antibody production during immune response" RELATED [] +synonym: "antibody secretion during immune response" RELATED [] +synonym: "immunoglobulin biosynthetic process involved in immune response" NARROW [] +synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] +synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] +synonym: "immunoglobulin production involved in immunoglobulin mediated immune response" EXACT [] +synonym: "immunoglobulin secretion involved in immune response" NARROW [] +is_a: GO:0002377 ! immunoglobulin production +relationship: part_of GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002382 +name: regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002256 ! regulation of kinin cascade +relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002383 +name: immune response in brain or nervous system +namespace: biological_process +def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002384 +name: hepatic immune response +namespace: biological_process +def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002385 +name: mucosal immune response +namespace: biological_process +alt_id: GO:0002386 +alt_id: GO:0002422 +def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +synonym: "immune response in MALT" NARROW [] +synonym: "immune response in mucosal-associated lymphoid tissue" NARROW [] +synonym: "immune response in urogenital tract" NARROW [] +is_a: GO:0002251 ! organ or tissue specific immune response + +[Term] +id: GO:0002387 +name: immune response in gut-associated lymphoid tissue +namespace: biological_process +def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149] +synonym: "immune response in GALT" EXACT [] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002388 +name: immune response in Peyer's patch +namespace: biological_process +def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149] +is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue + +[Term] +id: GO:0002389 +name: tolerance induction in Peyer's patch +namespace: biological_process +def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149] +is_a: GO:0002388 ! immune response in Peyer's patch +is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue + +[Term] +id: GO:0002391 +name: platelet activating factor production involved in inflammatory response +namespace: biological_process +alt_id: GO:0002390 +alt_id: GO:0002392 +alt_id: GO:0002535 +def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "platelet activating factor production" RELATED [] +synonym: "platelet activating factor production involved in acute inflammatory response" NARROW [] +synonym: "platelet activating factor secretion" NARROW [] +synonym: "platelet activating factor secretion involved in acute inflammatory response" NARROW [] +synonym: "platelet activating factor secretion involved in inflammatory response" NARROW [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002393 +name: lysosomal enzyme production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] +synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah] +synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] +synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002394 +name: tolerance induction in gut-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149] +synonym: "oral tolerance" RELATED [] +synonym: "tolerance induction in GALT" EXACT [] +is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002395 +name: immune response in nasopharyngeal-associated lymphoid tissue +namespace: biological_process +def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149] +synonym: "immune response in NALT" EXACT [] +is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue + +[Term] +id: GO:0002396 +name: MHC protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0002397 +name: MHC class I protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002398 +name: MHC class Ib protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002399 +name: MHC class II protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002396 ! MHC protein complex assembly + +[Term] +id: GO:0002400 +name: tolerance induction in nasopharyngeal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149] +synonym: "nasal tolerance" RELATED [] +synonym: "tolerance induction in NALT" EXACT [] +is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue +is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue + +[Term] +id: GO:0002401 +name: tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149] +synonym: "tolerance induction in MALT" EXACT [] +is_a: GO:0002427 ! mucosal tolerance induction + +[Term] +id: GO:0002402 +name: B cell tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149] +synonym: "B cell tolerance induction in MALT" EXACT [] +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue +is_a: GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002403 +name: T cell tolerance induction in mucosal-associated lymphoid tissue +namespace: biological_process +def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] +synonym: "T cell tolerance induction in MALT" EXACT [] +is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue +is_a: GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002404 +name: antigen sampling in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] +synonym: "antigen sampling in MALT" EXACT [] +synonym: "antigen transport in MALT" RELATED [] +synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002405 +name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] +synonym: "antigen sampling by dendritic cells in MALT" EXACT [] +is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue +relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002406 +name: antigen sampling by M cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] +synonym: "antigen sampling by M cells in MALT" EXACT [] +is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002407 +name: dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:0036336 ! dendritic cell migration + +[Term] +id: GO:0002408 +name: myeloid dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] +is_a: GO:0002407 ! dendritic cell chemotaxis +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:0002409 +name: Langerhans cell chemotaxis +namespace: biological_process +def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] +is_a: GO:0002408 ! myeloid dendritic cell chemotaxis + +[Term] +id: GO:0002410 +name: plasmacytoid dendritic cell chemotaxis +namespace: biological_process +def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] +is_a: GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:0002411 +name: T cell tolerance induction to tumor cell +namespace: biological_process +def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0002413 ! tolerance induction to tumor cell +is_a: GO:0002424 ! T cell mediated immune response to tumor cell +is_a: GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002412 +name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue +namespace: biological_process +def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411] +synonym: "antigen transcytosis by M cells in MALT" EXACT [] +synonym: "antigen transport by M cells in MALT" EXACT [] +synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] +is_a: GO:0045056 ! transcytosis +relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue + +[Term] +id: GO:0002413 +name: tolerance induction to tumor cell +namespace: biological_process +def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] +is_a: GO:0002418 ! immune response to tumor cell +is_a: GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002414 +name: immunoglobulin transcytosis in epithelial cells +namespace: biological_process +def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] +is_a: GO:0045056 ! transcytosis + +[Term] +id: GO:0002415 +name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor +namespace: biological_process +def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] +synonym: "antibody transcytosis mediated by pIgR" EXACT [] +synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] +is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells +relationship: part_of GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002416 +name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor +namespace: biological_process +def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X] +synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] +synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] +is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells + +[Term] +id: GO:0002417 +name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen +namespace: biological_process +def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] +is_a: GO:0002450 ! B cell antigen processing and presentation +is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis + +[Term] +id: GO:0002418 +name: immune response to tumor cell +namespace: biological_process +def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002419 +name: T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0001913 ! T cell mediated cytotoxicity +is_a: GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002420 +name: natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell +is_a: GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0002421 +name: B cell antigen processing and presentation following pinocytosis +namespace: biological_process +def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] +synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] +synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] +is_a: GO:0002450 ! B cell antigen processing and presentation +is_a: GO:0002746 ! antigen processing and presentation following pinocytosis + +[Term] +id: GO:0002423 +name: natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] +is_a: GO:0002228 ! natural killer cell mediated immunity +is_a: GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002424 +name: T cell mediated immune response to tumor cell +namespace: biological_process +def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] +comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. +is_a: GO:0002418 ! immune response to tumor cell +is_a: GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002425 +name: tolerance induction in urogenital tract +namespace: biological_process +def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] +is_a: GO:0002427 ! mucosal tolerance induction + +[Term] +id: GO:0002426 +name: immunoglobulin production in mucosal tissue +namespace: biological_process +def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "antibody production in mucosal tissue" EXACT [] +is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin-mediated immune response +relationship: part_of GO:0002385 ! mucosal immune response + +[Term] +id: GO:0002427 +name: mucosal tolerance induction +namespace: biological_process +def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] +is_a: GO:0002385 ! mucosal immune response +is_a: GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002428 +name: antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] +synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002429 +name: immune response-activating cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] +synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002757 ! immune response-activating signal transduction +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway + +[Term] +id: GO:0002430 +name: complement receptor mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "complement receptor mediated signalling pathway" EXACT [] +synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0002431 +name: Fc receptor mediated stimulatory signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] +synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0002432 +name: granuloma formation +namespace: biological_process +def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X] +is_a: GO:0002252 ! immune effector process +relationship: part_of GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002433 +name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis +namespace: biological_process +def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, ISBN:0781735149] +synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah] +synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0002434 +name: immune complex clearance +namespace: biological_process +def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, ISBN:068340007X] +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0002435 +name: immune complex clearance by erythrocytes +namespace: biological_process +def: "The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation." [GOC:add, PMID:11414352, PMID:24022490] +synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] +synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] +xref: Wikipedia:Immune_complex +is_a: GO:0002434 ! immune complex clearance + +[Term] +id: GO:0002436 +name: immune complex clearance by monocytes and macrophages +namespace: biological_process +def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149] +is_a: GO:0002434 ! immune complex clearance + +[Term] +id: GO:0002437 +name: inflammatory response to antigenic stimulus +namespace: biological_process +def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149] +is_a: GO:0006954 ! inflammatory response +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0002438 +name: acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002437 ! inflammatory response to antigenic stimulus +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002439 +name: chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149] +is_a: GO:0002437 ! inflammatory response to antigenic stimulus +is_a: GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002440 +name: production of molecular mediator of immune response +namespace: biological_process +def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, ISBN:0781735149] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "production of cellular mediator of immune response" RELATED [] +is_a: GO:0002376 ! immune system process +is_a: GO:0010467 ! gene expression + +[Term] +id: GO:0002441 +name: histamine secretion involved in inflammatory response +namespace: biological_process +def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "histamine secretion involved in acute inflammatory response" BROAD [] +is_a: GO:0001821 ! histamine secretion +is_a: GO:0046879 ! hormone secretion +relationship: part_of GO:0002349 ! histamine production involved in inflammatory response + +[Term] +id: GO:0002442 +name: serotonin secretion involved in inflammatory response +namespace: biological_process +def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] +synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] +synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] +is_a: GO:0001820 ! serotonin secretion +relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response + +[Term] +id: GO:0002443 +name: leukocyte mediated immunity +namespace: biological_process +alt_id: GO:0019723 +alt_id: GO:0042087 +def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "cell-mediated immune response" RELATED [] +synonym: "cellular immune response" RELATED [] +synonym: "immune cell effector process" EXACT [] +synonym: "immune cell mediated immunity" EXACT [] +synonym: "leucocyte immune effector process" EXACT [] +synonym: "leucocyte mediated immunity" EXACT [] +synonym: "leukocyte immune effector process" EXACT [] +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0002444 +name: myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "myeloid leucocyte immune effector process" EXACT [] +synonym: "myeloid leucocyte mediated immunity" EXACT [] +synonym: "myeloid leukocyte immune effector process" EXACT [] +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002445 +name: type II hypersensitivity +namespace: biological_process +def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] +xref: Wikipedia:Type_II_hypersensitivity +is_a: GO:0002444 ! myeloid leukocyte mediated immunity +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002446 +name: neutrophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002447 +name: eosinophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002448 +name: mast cell mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002449 +name: lymphocyte mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "cell-mediated immunity" BROAD [] +synonym: "cellular immune response" BROAD [] +is_a: GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002450 +name: B cell antigen processing and presentation +namespace: biological_process +def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "B lymphocyte antigen processing and presentation" EXACT [] +synonym: "B-cell antigen processing and presentation" EXACT [] +synonym: "B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation +relationship: part_of GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002451 +name: peripheral B cell tolerance induction +namespace: biological_process +def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149] +synonym: "peripheral B lymphocyte tolerance induction" EXACT [] +synonym: "peripheral B-cell tolerance induction" EXACT [] +synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002514 ! B cell tolerance induction +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002452 +name: B cell receptor editing +namespace: biological_process +def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149] +synonym: "B lymphocyte receptor editing" EXACT [] +synonym: "B-cell receptor editing" EXACT [] +synonym: "B-lymphocyte receptor editing" EXACT [] +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002453 +name: peripheral B cell anergy +namespace: biological_process +def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149] +synonym: "peripheral B lymphocyte anergy" EXACT [] +synonym: "peripheral B-cell anergy" EXACT [] +synonym: "peripheral B-lymphocyte anergy" EXACT [] +is_a: GO:0002515 ! B cell anergy +relationship: part_of GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002454 +name: peripheral B cell deletion +namespace: biological_process +def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149] +synonym: "peripheral B lymphocyte deletion" EXACT [] +synonym: "peripheral B-cell deletion" EXACT [] +synonym: "peripheral B-lymphocyte deletion" EXACT [] +is_a: GO:0002516 ! B cell deletion +relationship: part_of GO:0002451 ! peripheral B cell tolerance induction + +[Term] +id: GO:0002455 +name: humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "circulating antibody mediated immune response" EXACT [] +synonym: "circulating immunoglobulin mediated immune response" EXACT [] +synonym: "humoral defence mechanism" RELATED [] +synonym: "humoral immune response mediated by circulating antibody" EXACT [] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002456 +name: T cell mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "cell-mediated immunity" BROAD [] +synonym: "cellular immune response" BROAD [] +synonym: "T lymphocyte mediated immunity" EXACT [] +synonym: "T-cell mediated immunity" EXACT [] +synonym: "T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002457 +name: T cell antigen processing and presentation +namespace: biological_process +def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] +synonym: "T lymphocyte antigen processing and presentation" EXACT [] +synonym: "T-cell antigen processing and presentation" EXACT [] +synonym: "T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation +relationship: part_of GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002458 +name: peripheral T cell tolerance induction +namespace: biological_process +def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149] +synonym: "peripheral T lymphocyte tolerance induction" EXACT [] +synonym: "peripheral T-cell tolerance induction" EXACT [] +synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002456 ! T cell mediated immunity +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002459 +name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains +namespace: biological_process +def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] +synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] +synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] +synonym: "adaptive immune response in jawless fish" EXACT [] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002460 +name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002461 +name: tolerance induction dependent upon immune response +namespace: biological_process +def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +synonym: "immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002462 +name: tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002463 +name: central tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] +is_a: GO:0002462 ! tolerance induction to nonself antigen +is_a: GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002464 +name: peripheral tolerance induction to nonself antigen +namespace: biological_process +def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149] +is_a: GO:0002462 ! tolerance induction to nonself antigen +is_a: GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002465 +name: peripheral tolerance induction +namespace: biological_process +def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002466 +name: peripheral tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149] +is_a: GO:0002465 ! peripheral tolerance induction +is_a: GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002467 +name: germinal center formation +namespace: biological_process +def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, ISBN:081533642X] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0002468 +name: dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002469 +name: myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002470 +name: plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002471 +name: monocyte antigen processing and presentation +namespace: biological_process +def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002472 +name: macrophage antigen processing and presentation +namespace: biological_process +def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002473 +name: non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002474 +name: antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] +synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002475 +name: antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002476 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen + +[Term] +id: GO:0002477 +name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen + +[Term] +id: GO:0002478 +name: antigen processing and presentation of exogenous peptide antigen +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] +synonym: "exogenous peptide antigen processing and presentation" EXACT [] +is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002479 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] +synonym: "cross presentation" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] +synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I + +[Term] +id: GO:0002480 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] +synonym: "cross presentation" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] +synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I + +[Term] +id: GO:0002481 +name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] +synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002482 +name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] +synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002483 +name: antigen processing and presentation of endogenous peptide antigen +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] +synonym: "endogenous peptide antigen processing and presentation" EXACT [] +is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002484 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:0002485 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] +synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway + +[Term] +id: GO:0002486 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] +synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] +is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway + +[Term] +id: GO:0002487 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] +synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] +is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:0002488 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib + +[Term] +id: GO:0002489 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] +synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] +synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway + +[Term] +id: GO:0002490 +name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] +synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] +synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] +is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway + +[Term] +id: GO:0002491 +name: antigen processing and presentation of endogenous peptide antigen via MHC class II +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] +synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen +is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002492 +name: peptide antigen assembly with MHC class Ib protein complex +namespace: biological_process +def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly +relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002493 +name: lipid antigen assembly with MHC class Ib protein complex +namespace: biological_process +def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0065005 ! protein-lipid complex assembly +relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly +relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002494 +name: lipid antigen transport +namespace: biological_process +def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] +is_a: GO:0006869 ! lipid transport +relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002495 +name: antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591] +synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002496 +name: proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002497 +name: proteasomal proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002498 +name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] +synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002499 +name: proteolysis within endosome associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002500 +name: proteolysis within lysosome associated with antigen processing and presentation +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002501 +name: peptide antigen assembly with MHC protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0002396 ! MHC protein complex assembly +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002502 +name: peptide antigen assembly with MHC class I protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002397 ! MHC class I protein complex assembly +relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002503 +name: peptide antigen assembly with MHC class II protein complex +namespace: biological_process +def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex +relationship: part_of GO:0002399 ! MHC class II protein complex assembly +relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002504 +name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] +synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002505 +name: antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] +synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002507 +name: tolerance induction +namespace: biological_process +def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0002508 +name: central tolerance induction +namespace: biological_process +def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002509 +name: central tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002510 +name: central B cell tolerance induction +namespace: biological_process +def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] +synonym: "central B lymphocyte tolerance induction" EXACT [] +synonym: "central B-cell tolerance induction" EXACT [] +synonym: "central B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002511 +name: central B cell receptor editing +namespace: biological_process +def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] +synonym: "central B lymphocyte receptor editing" EXACT [] +synonym: "central B-cell receptor editing" EXACT [] +synonym: "central B-lymphocyte receptor editing" EXACT [] +is_a: GO:0002452 ! B cell receptor editing + +[Term] +id: GO:0002512 +name: central T cell tolerance induction +namespace: biological_process +def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149] +synonym: "central T lymphocyte tolerance induction" EXACT [] +synonym: "central T-cell tolerance induction" EXACT [] +synonym: "central T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002508 ! central tolerance induction +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002513 +name: tolerance induction to self antigen +namespace: biological_process +def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002514 +name: B cell tolerance induction +namespace: biological_process +def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922] +synonym: "B lymphocyte tolerance induction" EXACT [] +synonym: "B-cell tolerance induction" EXACT [] +synonym: "B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002515 +name: B cell anergy +namespace: biological_process +def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149] +synonym: "B lymphocyte anergy" EXACT [] +synonym: "B-cell anergy" EXACT [] +synonym: "B-lymphocyte anergy" EXACT [] +is_a: GO:0002249 ! lymphocyte anergy +is_a: GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002516 +name: B cell deletion +namespace: biological_process +def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149] +synonym: "B lymphocyte deletion" EXACT [] +synonym: "B-cell deletion" EXACT [] +synonym: "B-lymphocyte deletion" EXACT [] +is_a: GO:0001783 ! B cell apoptotic process +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002517 +name: T cell tolerance induction +namespace: biological_process +def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] +synonym: "T lymphocyte tolerance induction" EXACT [] +synonym: "T-cell tolerance induction" EXACT [] +synonym: "T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002518 +name: lymphocyte chemotaxis across high endothelial venule +namespace: biological_process +def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201] +is_a: GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0002519 +name: natural killer cell tolerance induction +namespace: biological_process +def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] +synonym: "NK cell tolerance induction" EXACT [] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0002520 +name: immune system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] +subset: goslim_drosophila +is_a: GO:0002376 ! immune system process +is_a: GO:0048731 ! system development + +[Term] +id: GO:0002521 +name: leukocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] +synonym: "immune cell differentiation" EXACT [] +synonym: "leucocyte differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0002522 +name: leukocyte migration involved in immune response +namespace: biological_process +def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration during immune response" EXACT [] +synonym: "immune cell trafficking during immune response" EXACT [] +synonym: "leucocyte migration during immune response" EXACT [] +synonym: "leucocyte trafficking during immune response" EXACT [] +synonym: "leukocyte trafficking during immune response" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0050900 ! leukocyte migration +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0002523 +name: leukocyte migration involved in inflammatory response +namespace: biological_process +def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration during inflammatory response" RELATED [] +synonym: "immune cell trafficking during inflammatory response" RELATED [] +synonym: "leucocyte migration during inflammatory response" RELATED [] +synonym: "leucocyte trafficking during inflammatory response" RELATED [] +synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] +synonym: "leukocyte trafficking during inflammatory response" RELATED [] +is_a: GO:0050900 ! leukocyte migration +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002524 +name: hypersensitivity +namespace: biological_process +def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149] +synonym: "hypersensitivity response" RELATED [ISBN:0781735149] +xref: Wikipedia:Hypersensitivity +is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002525 +name: acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002526 +name: acute inflammatory response +namespace: biological_process +def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, ISBN:0781735149] +is_a: GO:0006954 ! inflammatory response + +[Term] +id: GO:0002527 +name: vasodilation involved in acute inflammatory response +namespace: biological_process +def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] +synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002528 +name: regulation of vascular permeability involved in acute inflammatory response +namespace: biological_process +def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] +synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] +is_a: GO:0043114 ! regulation of vascular permeability +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002529 +name: regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +is_a: GO:0002256 ! regulation of kinin cascade +relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002530 +name: regulation of systemic arterial blood pressure involved in acute-phase response +namespace: biological_process +def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] +synonym: "blood pressure regulation during acute phase response" RELATED [] +synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +relationship: part_of GO:0006953 ! acute-phase response + +[Term] +id: GO:0002531 +name: regulation of heart contraction involved in acute-phase response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] +synonym: "regulation of cardiac contraction during acute phase response" RELATED [] +synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] +is_a: GO:0008016 ! regulation of heart contraction +relationship: part_of GO:0006953 ! acute-phase response + +[Term] +id: GO:0002532 +name: production of molecular mediator involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] +synonym: "production of cellular mediator of acute inflammation" RELATED [] +synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0006954 ! inflammatory response + +[Term] +id: GO:0002533 +name: lysosomal enzyme secretion involved in inflammatory response +namespace: biological_process +def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514] +synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah] +synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] +synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [] +is_a: GO:0033299 ! secretion of lysosomal enzymes +relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response + +[Term] +id: GO:0002534 +name: cytokine production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +subset: gocheck_do_not_annotate +synonym: "cytokine production involved in acute inflammatory response" BROAD [] +is_a: GO:0001816 ! cytokine production +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002536 +name: respiratory burst involved in inflammatory response +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "oxidative burst during acute inflammatory response" BROAD [] +synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] +synonym: "respiratory burst involved in acute inflammatory response" BROAD [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response +is_a: GO:0002679 ! respiratory burst involved in defense response + +[Term] +id: GO:0002537 +name: nitric oxide production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] +synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] +synonym: "production of nitric oxide involved in inflammatory response" EXACT [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002538 +name: arachidonic acid metabolite production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] +synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] +synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [] +is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response + +[Term] +id: GO:0002539 +name: prostaglandin production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] +is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response + +[Term] +id: GO:0002540 +name: leukotriene production involved in inflammatory response +namespace: biological_process +def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] +synonym: "leukotriene production involved in acute inflammatory response" BROAD [] +is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response + +[Term] +id: GO:0002541 +name: activation of plasma proteins involved in acute inflammatory response +namespace: biological_process +def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149] +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002542 +name: Factor XII activation +namespace: biological_process +def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] +synonym: "Hageman factor activation" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0010954 ! positive regulation of protein processing +relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade +relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response + +[Term] +id: GO:0002543 +name: activation of blood coagulation via clotting cascade +namespace: biological_process +def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149] +synonym: "activation of clotting cascade" EXACT [] +is_a: GO:0030194 ! positive regulation of blood coagulation +relationship: part_of GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002544 +name: chronic inflammatory response +namespace: biological_process +def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, ISBN:0781735149] +is_a: GO:0006954 ! inflammatory response + +[Term] +id: GO:0002545 +name: chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] +is_a: GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002546 +name: negative regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] +synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] +is_a: GO:0002257 ! negative regulation of kinin cascade +is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade +relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002547 +name: positive regulation of tissue kallikrein-kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] +synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] +synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] +synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] +synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] +synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] +is_a: GO:0002258 ! positive regulation of kinin cascade +is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade +relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade + +[Term] +id: GO:0002548 +name: monocyte chemotaxis +namespace: biological_process +def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:0071674 ! mononuclear cell migration +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:0002549 +name: negative regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] +is_a: GO:0002257 ! negative regulation of kinin cascade +is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade +relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002550 +name: positive regulation of plasma kallikrein-kinin cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] +synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] +synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] +synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] +synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] +is_a: GO:0002258 ! positive regulation of kinin cascade +is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade +relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade + +[Term] +id: GO:0002551 +name: mast cell chemotaxis +namespace: biological_process +def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:0097531 ! mast cell migration + +[Term] +id: GO:0002552 +name: serotonin secretion by mast cell +namespace: biological_process +def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] +synonym: "serotonin release by mast cell" RELATED [GOC:tb] +is_a: GO:0002442 ! serotonin secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0002553 +name: histamine secretion by mast cell +namespace: biological_process +def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] +is_a: GO:0002441 ! histamine secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0002554 +name: serotonin secretion by platelet +namespace: biological_process +def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149] +synonym: "serotonin release by platelet" RELATED [GOC:tb] +is_a: GO:0002442 ! serotonin secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0002576 ! platelet degranulation + +[Term] +id: GO:0002555 +name: histamine secretion by platelet +namespace: biological_process +def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] +is_a: GO:0002441 ! histamine secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0002576 ! platelet degranulation + +[Term] +id: GO:0002556 +name: serotonin secretion by basophil +namespace: biological_process +def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149] +synonym: "serotonin release by basophil" RELATED [GOC:tb] +is_a: GO:0002442 ! serotonin secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0002561 ! basophil degranulation + +[Term] +id: GO:0002557 +name: histamine secretion by basophil +namespace: biological_process +def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149] +is_a: GO:0002441 ! histamine secretion involved in inflammatory response +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0002561 ! basophil degranulation + +[Term] +id: GO:0002558 +name: type I hypersensitivity mediated by mast cells +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] +is_a: GO:0002448 ! mast cell mediated immunity +is_a: GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0002559 +name: type I hypersensitivity mediated by basophils +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] +is_a: GO:0002560 ! basophil mediated immunity +is_a: GO:0016068 ! type I hypersensitivity + +[Term] +id: GO:0002560 +name: basophil mediated immunity +namespace: biological_process +def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149] +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002561 +name: basophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149] +is_a: GO:0002276 ! basophil activation involved in immune response +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0002560 ! basophil mediated immunity + +[Term] +id: GO:0002562 +name: somatic diversification of immune receptors via germline recombination within a single locus +namespace: biological_process +def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] +is_a: GO:0002200 ! somatic diversification of immune receptors +is_a: GO:0016444 ! somatic cell DNA recombination + +[Term] +id: GO:0002563 +name: somatic diversification of immune receptors via alternate splicing +namespace: biological_process +def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002564 +name: alternate splicing of immunoglobulin genes +namespace: biological_process +def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563] +synonym: "alternate splicing of antibody genes" EXACT [] +is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0002565 +name: somatic diversification of immune receptors via gene conversion +namespace: biological_process +def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149] +is_a: GO:0002200 ! somatic diversification of immune receptors +is_a: GO:0016444 ! somatic cell DNA recombination + +[Term] +id: GO:0002566 +name: somatic diversification of immune receptors via somatic mutation +namespace: biological_process +def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002567 +name: somatic diversification of FREP-based immune receptors +namespace: biological_process +def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575] +comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002568 +name: somatic diversification of T cell receptor genes +namespace: biological_process +def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149] +synonym: "somatic diversification of TCR genes" EXACT [] +is_a: GO:0002200 ! somatic diversification of immune receptors +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002569 +name: somatic diversification of immune receptors by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149] +is_a: GO:0002200 ! somatic diversification of immune receptors + +[Term] +id: GO:0002570 +name: somatic diversification of immunoglobulin genes by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149] +synonym: "somatic diversification of antibody genes by N region addition" EXACT [] +is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition +is_a: GO:0016445 ! somatic diversification of immunoglobulins +relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments + +[Term] +id: GO:0002571 +name: somatic diversification of T cell receptor genes by N region addition +namespace: biological_process +def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149] +synonym: "somatic diversification of TCR genes by N region addition" EXACT [] +is_a: GO:0002568 ! somatic diversification of T cell receptor genes +is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition +relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments + +[Term] +id: GO:0002572 +name: pro-T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] +synonym: "pro-T lymphocyte differentiation" EXACT [] +is_a: GO:0002320 ! lymphoid progenitor cell differentiation +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0002573 +name: myeloid leukocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] +synonym: "myeloid leucocyte differentiation" EXACT [] +is_a: GO:0002521 ! leukocyte differentiation +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0002574 +name: thrombocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] +comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0002575 +name: basophil chemotaxis +namespace: biological_process +def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] +is_a: GO:0071621 ! granulocyte chemotaxis + +[Term] +id: GO:0002576 +name: platelet degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] +synonym: "platelet exocytosis" EXACT [] +is_a: GO:0045055 ! regulated exocytosis +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0002577 +name: regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +relationship: regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002578 +name: negative regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +synonym: "down regulation of antigen processing and presentation" EXACT [] +synonym: "down-regulation of antigen processing and presentation" EXACT [] +synonym: "downregulation of antigen processing and presentation" EXACT [] +synonym: "inhibition of antigen processing and presentation" NARROW [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002683 ! negative regulation of immune system process +relationship: negatively_regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002579 +name: positive regulation of antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] +synonym: "activation of antigen processing and presentation" NARROW [] +synonym: "stimulation of antigen processing and presentation" NARROW [] +synonym: "up regulation of antigen processing and presentation" EXACT [] +synonym: "up-regulation of antigen processing and presentation" EXACT [] +synonym: "upregulation of antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002684 ! positive regulation of immune system process +relationship: positively_regulates GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002580 +name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002581 +name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002582 +name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II + +[Term] +id: GO:0002583 +name: regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002584 +name: negative regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002585 +name: positive regulation of antigen processing and presentation of peptide antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0002586 +name: regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002587 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II +relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002588 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] +is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II +relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0002589 +name: regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002590 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I +relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002591 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I +relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0002592 +name: regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002593 +name: negative regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002594 +name: positive regulation of antigen processing and presentation via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] +synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0002595 +name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002596 +name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib +relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002597 +name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib +relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib + +[Term] +id: GO:0002598 +name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib +relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002599 +name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib +relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002600 +name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] +synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] +synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] +synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] +is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib +is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib +relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0002601 +name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002602 +name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002603 +name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] +synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] +synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] +synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] +is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II +is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II +relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II + +[Term] +id: GO:0002604 +name: regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002605 +name: negative regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002606 +name: positive regulation of dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation + +[Term] +id: GO:0002607 +name: regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002608 +name: negative regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation +is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002609 +name: positive regulation of myeloid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation +is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002610 +name: regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation +relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002611 +name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation +is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation +relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002612 +name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] +synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] +synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] +is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation +is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation +relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation + +[Term] +id: GO:0002613 +name: regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002614 +name: negative regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] +synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation +relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002615 +name: positive regulation of monocyte antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] +synonym: "activation of monocyte antigen processing and presentation" NARROW [] +synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] +synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] +synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation +relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation + +[Term] +id: GO:0002616 +name: regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002617 +name: negative regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] +synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation +relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002618 +name: positive regulation of macrophage antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] +synonym: "activation of macrophage antigen processing and presentation" NARROW [] +synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] +synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] +synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation +relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation + +[Term] +id: GO:0002619 +name: regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +is_a: GO:0002577 ! regulation of antigen processing and presentation +relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002620 +name: negative regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation +relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002621 +name: positive regulation of non-professional antigen presenting cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] +synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] +synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation +relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation + +[Term] +id: GO:0002622 +name: regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002623 +name: negative regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of B cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] +synonym: "downregulation of B cell antigen processing and presentation" EXACT [] +synonym: "inhibition of B cell antigen processing and presentation" NARROW [] +synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002622 ! regulation of B cell antigen processing and presentation +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002624 +name: positive regulation of B cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] +synonym: "activation of B cell antigen processing and presentation" NARROW [] +synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] +synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] +synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] +synonym: "stimulation of B cell antigen processing and presentation" NARROW [] +synonym: "up regulation of B cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] +synonym: "upregulation of B cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002622 ! regulation of B cell antigen processing and presentation +relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation + +[Term] +id: GO:0002625 +name: regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002577 ! regulation of antigen processing and presentation +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002626 +name: negative regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "down regulation of T cell antigen processing and presentation" EXACT [] +synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] +synonym: "downregulation of T cell antigen processing and presentation" EXACT [] +synonym: "inhibition of T cell antigen processing and presentation" NARROW [] +synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] +is_a: GO:0002578 ! negative regulation of antigen processing and presentation +is_a: GO:0002625 ! regulation of T cell antigen processing and presentation +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002627 +name: positive regulation of T cell antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] +synonym: "activation of T cell antigen processing and presentation" NARROW [] +synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] +synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] +synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] +synonym: "stimulation of T cell antigen processing and presentation" NARROW [] +synonym: "up regulation of T cell antigen processing and presentation" EXACT [] +synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] +synonym: "upregulation of T cell antigen processing and presentation" EXACT [] +is_a: GO:0002579 ! positive regulation of antigen processing and presentation +is_a: GO:0002625 ! regulation of T cell antigen processing and presentation +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation + +[Term] +id: GO:0002628 +name: regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process +relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002629 +name: negative regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation +is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process +relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002630 +name: positive regulation of proteolysis associated with antigen processing and presentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] +synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] +synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] +synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] +synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation +is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process +relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation + +[Term] +id: GO:0002631 +name: regulation of granuloma formation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002632 +name: negative regulation of granuloma formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] +synonym: "down regulation of granuloma formation" EXACT [] +synonym: "down-regulation of granuloma formation" EXACT [] +synonym: "downregulation of granuloma formation" EXACT [] +synonym: "inhibition of granuloma formation" NARROW [] +is_a: GO:0002631 ! regulation of granuloma formation +is_a: GO:0002677 ! negative regulation of chronic inflammatory response +is_a: GO:0002698 ! negative regulation of immune effector process +relationship: negatively_regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002633 +name: positive regulation of granuloma formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] +synonym: "activation of granuloma formation" NARROW [] +synonym: "stimulation of granuloma formation" NARROW [] +synonym: "up regulation of granuloma formation" EXACT [] +synonym: "up-regulation of granuloma formation" EXACT [] +synonym: "upregulation of granuloma formation" EXACT [] +is_a: GO:0002631 ! regulation of granuloma formation +is_a: GO:0002678 ! positive regulation of chronic inflammatory response +is_a: GO:0002699 ! positive regulation of immune effector process +relationship: positively_regulates GO:0002432 ! granuloma formation + +[Term] +id: GO:0002634 +name: regulation of germinal center formation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002635 +name: negative regulation of germinal center formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] +synonym: "down regulation of germinal center formation" EXACT [] +synonym: "down-regulation of germinal center formation" EXACT [] +synonym: "downregulation of germinal center formation" EXACT [] +synonym: "inhibition of germinal center formation" NARROW [] +is_a: GO:0002634 ! regulation of germinal center formation +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002636 +name: positive regulation of germinal center formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] +synonym: "activation of germinal center formation" NARROW [] +synonym: "stimulation of germinal center formation" NARROW [] +synonym: "up regulation of germinal center formation" EXACT [] +synonym: "up-regulation of germinal center formation" EXACT [] +synonym: "upregulation of germinal center formation" EXACT [] +is_a: GO:0002634 ! regulation of germinal center formation +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0002467 ! germinal center formation + +[Term] +id: GO:0002637 +name: regulation of immunoglobulin production +namespace: biological_process +alt_id: GO:0002640 +alt_id: GO:0051023 +def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] +synonym: "regulation of antibody production" EXACT [] +synonym: "regulation of immunoglobulin biosynthetic process" NARROW [] +synonym: "regulation of immunoglobulin secretion" NARROW [] +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002638 +name: negative regulation of immunoglobulin production +namespace: biological_process +alt_id: GO:0002641 +alt_id: GO:0051025 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] +synonym: "down regulation of immunoglobulin production" EXACT [] +synonym: "down-regulation of immunoglobulin production" EXACT [] +synonym: "downregulation of immunoglobulin production" EXACT [] +synonym: "inhibition of immunoglobulin production" NARROW [] +synonym: "negative regulation of immunoglobulin biosynthetic process" NARROW [] +synonym: "negative regulation of immunoglobulin secretion" NARROW [] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +relationship: negatively_regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002639 +name: positive regulation of immunoglobulin production +namespace: biological_process +alt_id: GO:0002642 +alt_id: GO:0051024 +def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] +synonym: "activation of immunoglobulin production" NARROW [] +synonym: "positive regulation of immunoglobulin biosynthetic process" NARROW [] +synonym: "positive regulation of immunoglobulin secretion" NARROW [] +synonym: "stimulation of immunoglobulin production" NARROW [] +synonym: "up regulation of immunoglobulin production" EXACT [] +synonym: "up-regulation of immunoglobulin production" EXACT [] +synonym: "upregulation of immunoglobulin production" EXACT [] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +relationship: positively_regulates GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0002643 +name: regulation of tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +relationship: regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002644 +name: negative regulation of tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] +synonym: "down regulation of tolerance induction" EXACT [] +synonym: "down-regulation of tolerance induction" EXACT [] +synonym: "downregulation of tolerance induction" EXACT [] +synonym: "inhibition of tolerance induction" NARROW [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002645 +name: positive regulation of tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] +synonym: "activation of tolerance induction" NARROW [] +synonym: "stimulation of tolerance induction" NARROW [] +synonym: "up regulation of tolerance induction" EXACT [] +synonym: "up-regulation of tolerance induction" EXACT [] +synonym: "upregulation of tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0002507 ! tolerance induction + +[Term] +id: GO:0002646 +name: regulation of central tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002647 +name: negative regulation of central tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] +synonym: "down regulation of central tolerance induction" EXACT [] +synonym: "down-regulation of central tolerance induction" EXACT [] +synonym: "downregulation of central tolerance induction" EXACT [] +synonym: "inhibition of central tolerance induction" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002646 ! regulation of central tolerance induction +relationship: negatively_regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002648 +name: positive regulation of central tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] +synonym: "activation of central tolerance induction" NARROW [] +synonym: "stimulation of central tolerance induction" NARROW [] +synonym: "up regulation of central tolerance induction" EXACT [] +synonym: "up-regulation of central tolerance induction" EXACT [] +synonym: "upregulation of central tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002646 ! regulation of central tolerance induction +relationship: positively_regulates GO:0002508 ! central tolerance induction + +[Term] +id: GO:0002649 +name: regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002650 +name: negative regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +synonym: "down regulation of tolerance induction to self antigen" EXACT [] +synonym: "down-regulation of tolerance induction to self antigen" EXACT [] +synonym: "downregulation of tolerance induction to self antigen" EXACT [] +synonym: "inhibition of tolerance induction to self antigen" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002649 ! regulation of tolerance induction to self antigen +relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002651 +name: positive regulation of tolerance induction to self antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] +synonym: "activation of tolerance induction to self antigen" NARROW [] +synonym: "stimulation of tolerance induction to self antigen" NARROW [] +synonym: "up regulation of tolerance induction to self antigen" EXACT [] +synonym: "up-regulation of tolerance induction to self antigen" EXACT [] +synonym: "upregulation of tolerance induction to self antigen" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002649 ! regulation of tolerance induction to self antigen +relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen + +[Term] +id: GO:0002652 +name: regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002653 +name: negative regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] +synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002654 +name: positive regulation of tolerance induction dependent upon immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] +synonym: "activation of tolerance induction dependent upon immune response" NARROW [] +synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] +synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] +synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] +synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response + +[Term] +id: GO:0002655 +name: regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +relationship: regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002656 +name: negative regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] +synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] +is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response +is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen +relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002657 +name: positive regulation of tolerance induction to nonself antigen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] +synonym: "activation of tolerance induction to nonself antigen" NARROW [] +synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] +synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] +synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] +is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response +is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen +relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen + +[Term] +id: GO:0002658 +name: regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response +relationship: regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002659 +name: negative regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +synonym: "down regulation of peripheral tolerance induction" EXACT [] +synonym: "down-regulation of peripheral tolerance induction" EXACT [] +synonym: "downregulation of peripheral tolerance induction" EXACT [] +synonym: "inhibition of peripheral tolerance induction" NARROW [] +is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002660 +name: positive regulation of peripheral tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] +synonym: "activation of peripheral tolerance induction" NARROW [] +synonym: "stimulation of peripheral tolerance induction" NARROW [] +synonym: "up regulation of peripheral tolerance induction" EXACT [] +synonym: "up-regulation of peripheral tolerance induction" EXACT [] +synonym: "upregulation of peripheral tolerance induction" EXACT [] +is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response +is_a: GO:0002658 ! regulation of peripheral tolerance induction +relationship: positively_regulates GO:0002465 ! peripheral tolerance induction + +[Term] +id: GO:0002661 +name: regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "regulation of B-cell tolerance induction" EXACT [] +synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002662 +name: negative regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "down regulation of B cell tolerance induction" EXACT [] +synonym: "down-regulation of B cell tolerance induction" EXACT [] +synonym: "downregulation of B cell tolerance induction" EXACT [] +synonym: "inhibition of B cell tolerance induction" NARROW [] +synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "negative regulation of B-cell tolerance induction" EXACT [] +synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: negatively_regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002663 +name: positive regulation of B cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] +synonym: "activation of B cell tolerance induction" NARROW [] +synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] +synonym: "positive regulation of B-cell tolerance induction" EXACT [] +synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] +synonym: "stimulation of B cell tolerance induction" NARROW [] +synonym: "up regulation of B cell tolerance induction" EXACT [] +synonym: "up-regulation of B cell tolerance induction" EXACT [] +synonym: "upregulation of B cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: positively_regulates GO:0002514 ! B cell tolerance induction + +[Term] +id: GO:0002664 +name: regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "regulation of T-cell tolerance induction" EXACT [] +synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002665 +name: negative regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "down regulation of T cell tolerance induction" EXACT [] +synonym: "down-regulation of T cell tolerance induction" EXACT [] +synonym: "downregulation of T cell tolerance induction" EXACT [] +synonym: "inhibition of T cell tolerance induction" NARROW [] +synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "negative regulation of T-cell tolerance induction" EXACT [] +synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +relationship: negatively_regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002666 +name: positive regulation of T cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] +synonym: "activation of T cell tolerance induction" NARROW [] +synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] +synonym: "positive regulation of T-cell tolerance induction" EXACT [] +synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] +synonym: "stimulation of T cell tolerance induction" NARROW [] +synonym: "up regulation of T cell tolerance induction" EXACT [] +synonym: "up-regulation of T cell tolerance induction" EXACT [] +synonym: "upregulation of T cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +relationship: positively_regulates GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002667 +name: regulation of T cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "regulation of T lymphocyte anergy" EXACT [] +synonym: "regulation of T-cell anergy" EXACT [] +synonym: "regulation of T-lymphocyte anergy" EXACT [] +is_a: GO:0002664 ! regulation of T cell tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002668 +name: negative regulation of T cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "down regulation of T cell anergy" EXACT [] +synonym: "down-regulation of T cell anergy" EXACT [] +synonym: "downregulation of T cell anergy" EXACT [] +synonym: "inhibition of T cell anergy" NARROW [] +synonym: "negative regulation of T lymphocyte anergy" EXACT [] +synonym: "negative regulation of T-cell anergy" EXACT [] +synonym: "negative regulation of T-lymphocyte anergy" EXACT [] +is_a: GO:0002665 ! negative regulation of T cell tolerance induction +is_a: GO:0002667 ! regulation of T cell anergy +is_a: GO:0002912 ! negative regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002669 +name: positive regulation of T cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] +synonym: "activation of T cell anergy" NARROW [] +synonym: "positive regulation of T lymphocyte anergy" EXACT [] +synonym: "positive regulation of T-cell anergy" EXACT [] +synonym: "positive regulation of T-lymphocyte anergy" EXACT [] +synonym: "stimulation of T cell anergy" NARROW [] +synonym: "up regulation of T cell anergy" EXACT [] +synonym: "up-regulation of T cell anergy" EXACT [] +synonym: "upregulation of T cell anergy" EXACT [] +is_a: GO:0002666 ! positive regulation of T cell tolerance induction +is_a: GO:0002667 ! regulation of T cell anergy +is_a: GO:0002913 ! positive regulation of lymphocyte anergy +relationship: positively_regulates GO:0002870 ! T cell anergy + +[Term] +id: GO:0002670 +name: regulation of B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "regulation of B lymphocyte anergy" EXACT [] +synonym: "regulation of B-cell anergy" EXACT [] +synonym: "regulation of B-lymphocyte anergy" EXACT [] +is_a: GO:0002661 ! regulation of B cell tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002671 +name: negative regulation of B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "down regulation of B cell anergy" EXACT [] +synonym: "down-regulation of B cell anergy" EXACT [] +synonym: "downregulation of B cell anergy" EXACT [] +synonym: "inhibition of B cell anergy" NARROW [] +synonym: "negative regulation of B lymphocyte anergy" EXACT [] +synonym: "negative regulation of B-cell anergy" EXACT [] +synonym: "negative regulation of B-lymphocyte anergy" EXACT [] +is_a: GO:0002662 ! negative regulation of B cell tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002912 ! negative regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002672 +name: positive regulation of B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] +synonym: "activation of B cell anergy" NARROW [] +synonym: "positive regulation of B lymphocyte anergy" EXACT [] +synonym: "positive regulation of B-cell anergy" EXACT [] +synonym: "positive regulation of B-lymphocyte anergy" EXACT [] +synonym: "stimulation of B cell anergy" NARROW [] +synonym: "up regulation of B cell anergy" EXACT [] +synonym: "up-regulation of B cell anergy" EXACT [] +synonym: "upregulation of B cell anergy" EXACT [] +is_a: GO:0002663 ! positive regulation of B cell tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002913 ! positive regulation of lymphocyte anergy +relationship: positively_regulates GO:0002515 ! B cell anergy + +[Term] +id: GO:0002673 +name: regulation of acute inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +relationship: regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002674 +name: negative regulation of acute inflammatory response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +synonym: "down regulation of acute inflammatory response" EXACT [] +synonym: "down-regulation of acute inflammatory response" EXACT [] +synonym: "downregulation of acute inflammatory response" EXACT [] +synonym: "inhibition of acute inflammatory response" NARROW [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0050728 ! negative regulation of inflammatory response +relationship: negatively_regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002675 +name: positive regulation of acute inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] +synonym: "activation of acute inflammatory response" NARROW [] +synonym: "stimulation of acute inflammatory response" NARROW [] +synonym: "up regulation of acute inflammatory response" EXACT [] +synonym: "up-regulation of acute inflammatory response" EXACT [] +synonym: "upregulation of acute inflammatory response" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0050729 ! positive regulation of inflammatory response +relationship: positively_regulates GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0002676 +name: regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +relationship: regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002677 +name: negative regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +synonym: "down regulation of chronic inflammatory response" EXACT [] +synonym: "down-regulation of chronic inflammatory response" EXACT [] +synonym: "downregulation of chronic inflammatory response" EXACT [] +synonym: "inhibition of chronic inflammatory response" NARROW [] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0050728 ! negative regulation of inflammatory response +relationship: negatively_regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002678 +name: positive regulation of chronic inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] +synonym: "activation of chronic inflammatory response" NARROW [] +synonym: "stimulation of chronic inflammatory response" NARROW [] +synonym: "up regulation of chronic inflammatory response" EXACT [] +synonym: "up-regulation of chronic inflammatory response" EXACT [] +synonym: "upregulation of chronic inflammatory response" EXACT [] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0050729 ! positive regulation of inflammatory response +relationship: positively_regulates GO:0002544 ! chronic inflammatory response + +[Term] +id: GO:0002679 +name: respiratory burst involved in defense response +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] +is_a: GO:0002252 ! immune effector process +is_a: GO:0045730 ! respiratory burst +relationship: part_of GO:0006952 ! defense response + +[Term] +id: GO:0002680 +name: pro-T cell lineage commitment +namespace: biological_process +def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149] +synonym: "pro-T cell fate commitment" EXACT [] +synonym: "pro-T lymphocyte fate commitment" EXACT [] +synonym: "pro-T lymphocyte lineage commitment" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0002572 ! pro-T cell differentiation + +[Term] +id: GO:0002681 +name: somatic recombination of T cell receptor gene segments +namespace: biological_process +def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149] +synonym: "somatic recombination of TCR gene segments" EXACT [] +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus +is_a: GO:0002568 ! somatic diversification of T cell receptor genes + +[Term] +id: GO:0002682 +name: regulation of immune system process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002683 +name: negative regulation of immune system process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] +synonym: "down regulation of immune system process" EXACT [] +synonym: "down-regulation of immune system process" EXACT [] +synonym: "downregulation of immune system process" EXACT [] +synonym: "inhibition of immune system process" NARROW [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002684 +name: positive regulation of immune system process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] +synonym: "activation of immune system process" NARROW [] +synonym: "stimulation of immune system process" NARROW [] +synonym: "up regulation of immune system process" EXACT [] +synonym: "up-regulation of immune system process" EXACT [] +synonym: "upregulation of immune system process" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0002376 ! immune system process + +[Term] +id: GO:0002685 +name: regulation of leukocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "regulation of immune cell migration" EXACT [] +synonym: "regulation of leucocyte migration" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002686 +name: negative regulation of leukocyte migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "down regulation of leukocyte migration" EXACT [] +synonym: "down-regulation of leukocyte migration" EXACT [] +synonym: "downregulation of leukocyte migration" EXACT [] +synonym: "inhibition of leukocyte migration" NARROW [] +synonym: "negative regulation of immune cell migration" EXACT [] +synonym: "negative regulation of leucocyte migration" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002687 +name: positive regulation of leukocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] +synonym: "activation of leukocyte migration" NARROW [] +synonym: "positive regulation of immune cell migration" EXACT [] +synonym: "positive regulation of leucocyte migration" EXACT [] +synonym: "stimulation of leukocyte migration" NARROW [] +synonym: "up regulation of leukocyte migration" EXACT [] +synonym: "up-regulation of leukocyte migration" EXACT [] +synonym: "upregulation of leukocyte migration" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0050900 ! leukocyte migration + +[Term] +id: GO:0002688 +name: regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "regulation of immune cell chemotaxis" EXACT [] +synonym: "regulation of leucocyte chemotaxis" EXACT [] +is_a: GO:0002685 ! regulation of leukocyte migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002689 +name: negative regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "down regulation of leukocyte chemotaxis" EXACT [] +synonym: "down-regulation of leukocyte chemotaxis" EXACT [] +synonym: "downregulation of leukocyte chemotaxis" EXACT [] +synonym: "inhibition of leukocyte chemotaxis" NARROW [] +synonym: "negative regulation of immune cell chemotaxis" EXACT [] +synonym: "negative regulation of leucocyte chemotaxis" EXACT [] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0050922 ! negative regulation of chemotaxis +relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002690 +name: positive regulation of leukocyte chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] +synonym: "activation of leukocyte chemotaxis" NARROW [] +synonym: "positive regulation of immune cell chemotaxis" EXACT [] +synonym: "positive regulation of leucocyte chemotaxis" EXACT [] +synonym: "stimulation of leukocyte chemotaxis" NARROW [] +synonym: "up regulation of leukocyte chemotaxis" EXACT [] +synonym: "up-regulation of leukocyte chemotaxis" EXACT [] +synonym: "upregulation of leukocyte chemotaxis" EXACT [] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0050921 ! positive regulation of chemotaxis +relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis + +[Term] +id: GO:0002691 +name: regulation of cellular extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002692 +name: negative regulation of cellular extravasation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] +synonym: "down regulation of cellular extravasation" EXACT [] +synonym: "down-regulation of cellular extravasation" EXACT [] +synonym: "downregulation of cellular extravasation" EXACT [] +synonym: "inhibition of cellular extravasation" NARROW [] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:0002691 ! regulation of cellular extravasation +relationship: negatively_regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002693 +name: positive regulation of cellular extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] +synonym: "activation of cellular extravasation" NARROW [] +synonym: "stimulation of cellular extravasation" NARROW [] +synonym: "up regulation of cellular extravasation" EXACT [] +synonym: "up-regulation of cellular extravasation" EXACT [] +synonym: "upregulation of cellular extravasation" EXACT [] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:0002691 ! regulation of cellular extravasation +relationship: positively_regulates GO:0045123 ! cellular extravasation + +[Term] +id: GO:0002694 +name: regulation of leukocyte activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "regulation of immune cell activation" EXACT [] +synonym: "regulation of leucocyte activation" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002695 +name: negative regulation of leukocyte activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "down regulation of leukocyte activation" EXACT [] +synonym: "down-regulation of leukocyte activation" EXACT [] +synonym: "downregulation of leukocyte activation" EXACT [] +synonym: "inhibition of leukocyte activation" NARROW [] +synonym: "negative regulation of immune cell activation" EXACT [] +synonym: "negative regulation of leucocyte activation" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0050866 ! negative regulation of cell activation +relationship: negatively_regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002696 +name: positive regulation of leukocyte activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] +synonym: "activation of leukocyte activation" NARROW [] +synonym: "positive regulation of immune cell activation" EXACT [] +synonym: "positive regulation of leucocyte activation" EXACT [] +synonym: "stimulation of leukocyte activation" NARROW [] +synonym: "up regulation of leukocyte activation" EXACT [] +synonym: "up-regulation of leukocyte activation" EXACT [] +synonym: "upregulation of leukocyte activation" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0050867 ! positive regulation of cell activation +relationship: positively_regulates GO:0045321 ! leukocyte activation + +[Term] +id: GO:0002697 +name: regulation of immune effector process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +relationship: regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002698 +name: negative regulation of immune effector process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] +synonym: "down regulation of immune effector process" EXACT [] +synonym: "down-regulation of immune effector process" EXACT [] +synonym: "downregulation of immune effector process" EXACT [] +synonym: "inhibition of immune effector process" NARROW [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0002697 ! regulation of immune effector process +relationship: negatively_regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002699 +name: positive regulation of immune effector process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] +synonym: "activation of immune effector process" NARROW [] +synonym: "stimulation of immune effector process" NARROW [] +synonym: "up regulation of immune effector process" EXACT [] +synonym: "up-regulation of immune effector process" EXACT [] +synonym: "upregulation of immune effector process" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002697 ! regulation of immune effector process +relationship: positively_regulates GO:0002252 ! immune effector process + +[Term] +id: GO:0002700 +name: regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002701 +name: negative regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +synonym: "down regulation of production of molecular mediator of immune response" EXACT [] +synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] +synonym: "downregulation of production of molecular mediator of immune response" EXACT [] +synonym: "inhibition of production of molecular mediator of immune response" NARROW [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +is_a: GO:0010629 ! negative regulation of gene expression +relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002702 +name: positive regulation of production of molecular mediator of immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] +synonym: "activation of production of molecular mediator of immune response" NARROW [] +synonym: "stimulation of production of molecular mediator of immune response" NARROW [] +synonym: "up regulation of production of molecular mediator of immune response" EXACT [] +synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] +synonym: "upregulation of production of molecular mediator of immune response" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +is_a: GO:0010628 ! positive regulation of gene expression +relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0002703 +name: regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "regulation of immune cell mediated immunity" EXACT [] +synonym: "regulation of leucocyte mediated immunity" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002704 +name: negative regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "down regulation of leukocyte mediated immunity" EXACT [] +synonym: "down-regulation of leukocyte mediated immunity" EXACT [] +synonym: "downregulation of leukocyte mediated immunity" EXACT [] +synonym: "inhibition of leukocyte mediated immunity" NARROW [] +synonym: "negative regulation of immune cell mediated immunity" EXACT [] +synonym: "negative regulation of leucocyte mediated immunity" EXACT [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002705 +name: positive regulation of leukocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] +synonym: "activation of leukocyte mediated immunity" NARROW [] +synonym: "positive regulation of immune cell mediated immunity" EXACT [] +synonym: "positive regulation of leucocyte mediated immunity" EXACT [] +synonym: "stimulation of leukocyte mediated immunity" NARROW [] +synonym: "up regulation of leukocyte mediated immunity" EXACT [] +synonym: "up-regulation of leukocyte mediated immunity" EXACT [] +synonym: "upregulation of leukocyte mediated immunity" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity + +[Term] +id: GO:0002706 +name: regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002707 +name: negative regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +synonym: "down regulation of lymphocyte mediated immunity" EXACT [] +synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] +synonym: "downregulation of lymphocyte mediated immunity" EXACT [] +synonym: "inhibition of lymphocyte mediated immunity" NARROW [] +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002708 +name: positive regulation of lymphocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] +synonym: "activation of lymphocyte mediated immunity" NARROW [] +synonym: "stimulation of lymphocyte mediated immunity" NARROW [] +synonym: "up regulation of lymphocyte mediated immunity" EXACT [] +synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] +synonym: "upregulation of lymphocyte mediated immunity" EXACT [] +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity + +[Term] +id: GO:0002709 +name: regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "regulation of T-cell mediated immunity" EXACT [] +synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002710 +name: negative regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "down regulation of T cell mediated immunity" EXACT [] +synonym: "down-regulation of T cell mediated immunity" EXACT [] +synonym: "downregulation of T cell mediated immunity" EXACT [] +synonym: "inhibition of T cell mediated immunity" NARROW [] +synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "negative regulation of T-cell mediated immunity" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002711 +name: positive regulation of T cell mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] +synonym: "activation of T cell mediated immunity" NARROW [] +synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] +synonym: "positive regulation of T-cell mediated immunity" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] +synonym: "stimulation of T cell mediated immunity" NARROW [] +synonym: "up regulation of T cell mediated immunity" EXACT [] +synonym: "up-regulation of T cell mediated immunity" EXACT [] +synonym: "upregulation of T cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002456 ! T cell mediated immunity + +[Term] +id: GO:0002712 +name: regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "regulation of B-cell mediated immunity" EXACT [] +synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002713 +name: negative regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "down regulation of B cell mediated immunity" EXACT [] +synonym: "down-regulation of B cell mediated immunity" EXACT [] +synonym: "downregulation of B cell mediated immunity" EXACT [] +synonym: "inhibition of B cell mediated immunity" NARROW [] +synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "negative regulation of B-cell mediated immunity" EXACT [] +synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002714 +name: positive regulation of B cell mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] +synonym: "activation of B cell mediated immunity" NARROW [] +synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] +synonym: "positive regulation of B-cell mediated immunity" EXACT [] +synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] +synonym: "stimulation of B cell mediated immunity" NARROW [] +synonym: "up regulation of B cell mediated immunity" EXACT [] +synonym: "up-regulation of B cell mediated immunity" EXACT [] +synonym: "upregulation of B cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0002715 +name: regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0045845 +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "regulation of natural killer cell activity" RELATED [] +synonym: "regulation of NK cell mediated immunity" EXACT [] +is_a: GO:0002706 ! regulation of lymphocyte mediated immunity +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002716 +name: negative regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0030102 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "down regulation of natural killer cell mediated immunity" EXACT [] +synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] +synonym: "downregulation of natural killer cell mediated immunity" EXACT [] +synonym: "inhibition of natural killer cell mediated immunity" NARROW [] +synonym: "negative regulation of natural killer cell activity" RELATED [] +synonym: "negative regulation of NK cell activity" RELATED [] +synonym: "negative regulation of NK cell mediated immunity" EXACT [] +is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002717 +name: positive regulation of natural killer cell mediated immunity +namespace: biological_process +alt_id: GO:0045846 +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] +synonym: "activation of natural killer cell mediated immunity" NARROW [] +synonym: "positive regulation of natural killer cell activity" RELATED [] +synonym: "positive regulation of NK cell activity" RELATED [] +synonym: "positive regulation of NK cell mediated immunity" EXACT [] +synonym: "stimulation of natural killer cell mediated immunity" NARROW [] +synonym: "up regulation of natural killer cell mediated immunity" EXACT [] +synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] +synonym: "upregulation of natural killer cell mediated immunity" EXACT [] +is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0002718 +name: regulation of cytokine production involved in immune response +namespace: biological_process +alt_id: GO:0002739 +alt_id: GO:0002742 +def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] +synonym: "regulation of cytokine biosynthetic process involved in immune response" NARROW [] +synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "regulation of cytokine secretion involved in immune response" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0002367 ! cytokine production involved in immune response + +[Term] +id: GO:0002719 +name: negative regulation of cytokine production involved in immune response +namespace: biological_process +alt_id: GO:0002740 +alt_id: GO:0002743 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] +synonym: "down regulation of cytokine production during immune response" RELATED [] +synonym: "down-regulation of cytokine production during immune response" EXACT [] +synonym: "downregulation of cytokine production during immune response" RELATED [] +synonym: "inhibition of cytokine production during immune response" RELATED [] +synonym: "negative regulation of cytokine biosynthetic process involved in immune response" NARROW [] +synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "negative regulation of cytokine secretion involved in immune response" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response + +[Term] +id: GO:0002720 +name: positive regulation of cytokine production involved in immune response +namespace: biological_process +alt_id: GO:0002741 +alt_id: GO:0002744 +def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] +synonym: "activation of cytokine production during immune response" NARROW [] +synonym: "positive regulation of cytokine biosynthetic process involved in immune response" NARROW [] +synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] +synonym: "positive regulation of cytokine secretion involved in immune response" NARROW [] +synonym: "stimulation of cytokine production during immune response" NARROW [] +synonym: "up regulation of cytokine production during immune response" RELATED [] +synonym: "up-regulation of cytokine production during immune response" RELATED [] +synonym: "upregulation of cytokine production during immune response" RELATED [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response + +[Term] +id: GO:0002721 +name: regulation of B cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "regulation of B lymphocyte cytokine production" EXACT [] +synonym: "regulation of B-cell cytokine production" EXACT [] +synonym: "regulation of B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002722 +name: negative regulation of B cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "down regulation of B cell cytokine production" EXACT [] +synonym: "down-regulation of B cell cytokine production" EXACT [] +synonym: "downregulation of B cell cytokine production" EXACT [] +synonym: "inhibition of B cell cytokine production" NARROW [] +synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] +synonym: "negative regulation of B-cell cytokine production" EXACT [] +synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0002721 ! regulation of B cell cytokine production +relationship: negatively_regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002723 +name: positive regulation of B cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] +synonym: "activation of B cell cytokine production" NARROW [] +synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] +synonym: "positive regulation of B-cell cytokine production" EXACT [] +synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] +synonym: "stimulation of B cell cytokine production" NARROW [] +synonym: "up regulation of B cell cytokine production" EXACT [] +synonym: "up-regulation of B cell cytokine production" EXACT [] +synonym: "upregulation of B cell cytokine production" EXACT [] +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response +is_a: GO:0002721 ! regulation of B cell cytokine production +relationship: positively_regulates GO:0002368 ! B cell cytokine production + +[Term] +id: GO:0002724 +name: regulation of T cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "regulation of T lymphocyte cytokine production" EXACT [] +synonym: "regulation of T-cell cytokine production" EXACT [] +synonym: "regulation of T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002725 +name: negative regulation of T cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "down regulation of T cell cytokine production" EXACT [] +synonym: "down-regulation of T cell cytokine production" EXACT [] +synonym: "downregulation of T cell cytokine production" EXACT [] +synonym: "inhibition of T cell cytokine production" NARROW [] +synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] +synonym: "negative regulation of T-cell cytokine production" EXACT [] +synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0002724 ! regulation of T cell cytokine production +relationship: negatively_regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002726 +name: positive regulation of T cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] +synonym: "activation of T cell cytokine production" NARROW [] +synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] +synonym: "positive regulation of T-cell cytokine production" EXACT [] +synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] +synonym: "stimulation of T cell cytokine production" NARROW [] +synonym: "up regulation of T cell cytokine production" EXACT [] +synonym: "up-regulation of T cell cytokine production" EXACT [] +synonym: "upregulation of T cell cytokine production" EXACT [] +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response +is_a: GO:0002724 ! regulation of T cell cytokine production +relationship: positively_regulates GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0002727 +name: regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "regulation of NK cell cytokine production" EXACT [] +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002728 +name: negative regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "down regulation of natural killer cell cytokine production" EXACT [] +synonym: "down-regulation of natural killer cell cytokine production" EXACT [] +synonym: "downregulation of natural killer cell cytokine production" EXACT [] +synonym: "inhibition of natural killer cell cytokine production" NARROW [] +synonym: "negative regulation of NK cell cytokine production" EXACT [] +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0002727 ! regulation of natural killer cell cytokine production +relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002729 +name: positive regulation of natural killer cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] +synonym: "activation of natural killer cell cytokine production" NARROW [] +synonym: "positive regulation of NK cell cytokine production" EXACT [] +synonym: "stimulation of natural killer cell cytokine production" NARROW [] +synonym: "up regulation of natural killer cell cytokine production" EXACT [] +synonym: "up-regulation of natural killer cell cytokine production" EXACT [] +synonym: "upregulation of natural killer cell cytokine production" EXACT [] +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response +is_a: GO:0002727 ! regulation of natural killer cell cytokine production +relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production + +[Term] +id: GO:0002730 +name: regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002731 +name: negative regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of dendritic cell cytokine production" EXACT [] +synonym: "downregulation of dendritic cell cytokine production" EXACT [] +synonym: "inhibition of dendritic cell cytokine production" NARROW [] +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002732 +name: positive regulation of dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] +synonym: "activation of dendritic cell cytokine production" NARROW [] +synonym: "stimulation of dendritic cell cytokine production" NARROW [] +synonym: "up regulation of dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of dendritic cell cytokine production" EXACT [] +synonym: "upregulation of dendritic cell cytokine production" EXACT [] +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production + +[Term] +id: GO:0002733 +name: regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002734 +name: negative regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] +is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production +is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002735 +name: positive regulation of myeloid dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] +synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] +synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] +synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] +synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] +is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production +is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response +relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production + +[Term] +id: GO:0002736 +name: regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +is_a: GO:0002730 ! regulation of dendritic cell cytokine production +relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002737 +name: negative regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] +is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production +is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production +relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002738 +name: positive regulation of plasmacytoid dendritic cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] +synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] +synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] +synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] +synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] +is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production +is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production +relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production + +[Term] +id: GO:0002745 +name: antigen processing and presentation initiated by receptor mediated uptake of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002746 +name: antigen processing and presentation following pinocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002747 +name: antigen processing and presentation following phagocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0002748 +name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149] +synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] +synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] +is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen + +[Term] +id: GO:0002749 +name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen +namespace: biological_process +def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122] +synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] +is_a: GO:0002747 ! antigen processing and presentation following phagocytosis +is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen + +[Term] +id: GO:0002750 +name: antigen processing and presentation following macropinocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] +is_a: GO:0002746 ! antigen processing and presentation following pinocytosis + +[Term] +id: GO:0002751 +name: antigen processing and presentation following receptor mediated endocytosis +namespace: biological_process +def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149] +is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen + +[Term] +id: GO:0002752 +name: cell surface pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] +synonym: "cell surface PAMP receptor signaling pathway" EXACT [] +synonym: "cell surface pathogen receptor signaling pathway" EXACT [] +synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] +synonym: "cell surface PRR signaling pathway" EXACT [] +is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway +is_a: GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0002753 +name: cytoplasmic pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] +synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] +synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] +synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] +synonym: "cytoplasmic PRR signaling pathway" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway +is_a: GO:0030522 ! intracellular receptor signaling pathway +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0002754 +name: intracellular endosomal pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] +synonym: "intracellular vesicle PAMP receptor signaling pathway" RELATED [] +synonym: "intracellular vesicle pathogen receptor signaling pathway" RELATED [] +synonym: "intracellular vesicle pattern recognition receptor signaling pathway" RELATED [] +synonym: "intracellular vesicle pattern recognition receptor signalling pathway" RELATED [] +synonym: "intracellular vesicle PRR signaling pathway" RELATED [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0002755 +name: MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +synonym: "MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0002756 +name: MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] +synonym: "MyD88-independent TLR signaling pathway" EXACT [] +synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0002757 +name: immune response-activating signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] +is_a: GO:0002253 ! activation of immune response +is_a: GO:0002764 ! immune response-regulating signaling pathway + +[Term] +id: GO:0002758 +name: innate immune response-activating signal transduction +namespace: biological_process +alt_id: GO:0009870 +alt_id: GO:0010204 +def: "A series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response." [GOC:jy, GOC:mah, PMID:11418339, PMID:28105028] +synonym: "defence response signaling pathway, resistance gene-dependent" RELATED [] +synonym: "defence response signaling pathway, resistance gene-independent" RELATED [] +synonym: "defence response signalling pathway, resistance gene-dependent" RELATED [] +synonym: "defence response signalling pathway, resistance gene-independent" RELATED [] +synonym: "defense response signaling pathway, resistance gene-dependent" RELATED [] +synonym: "defense response signaling pathway, resistance gene-independent" RELATED [] +synonym: "defense response signalling pathway, resistance gene-dependent" RELATED [] +synonym: "effector triggered immunity" BROAD [] +synonym: "effector-triggered immune signaling" RELATED [] +synonym: "effector-triggered immunity" BROAD [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0002757 ! immune response-activating signal transduction + +[Term] +id: GO:0002759 +name: regulation of antimicrobial humoral response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0002760 +name: positive regulation of antimicrobial humoral response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] +synonym: "activation of antimicrobial humoral response" NARROW [] +synonym: "stimulation of antimicrobial humoral response" NARROW [] +synonym: "up regulation of antimicrobial humoral response" EXACT [] +synonym: "up-regulation of antimicrobial humoral response" EXACT [] +synonym: "upregulation of antimicrobial humoral response" EXACT [] +is_a: GO:0002759 ! regulation of antimicrobial humoral response +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0032103 ! positive regulation of response to external stimulus +relationship: positively_regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0002761 +name: regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +is_a: GO:0045637 ! regulation of myeloid cell differentiation +is_a: GO:1902105 ! regulation of leukocyte differentiation +relationship: regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002762 +name: negative regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] +synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:1902106 ! negative regulation of leukocyte differentiation +relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002763 +name: positive regulation of myeloid leukocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] +synonym: "activation of myeloid leukocyte differentiation" NARROW [] +synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] +synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] +synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:1902107 ! positive regulation of leukocyte differentiation +relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0002764 +name: immune response-regulating signaling pathway +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah] +is_a: GO:0007165 ! signal transduction +is_a: GO:0050776 ! regulation of immune response + +[Term] +id: GO:0002765 +name: immune response-inhibiting signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149] +is_a: GO:0002764 ! immune response-regulating signaling pathway + +[Term] +id: GO:0002766 +name: innate immune response-inhibiting signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +is_a: GO:0002765 ! immune response-inhibiting signal transduction + +[Term] +id: GO:0002767 +name: immune response-inhibiting cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002765 ! immune response-inhibiting signal transduction +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway + +[Term] +id: GO:0002768 +name: immune response-regulating cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] +is_a: GO:0002764 ! immune response-regulating signaling pathway +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0002769 +name: natural killer cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "inhibitory KIR signaling pathway" NARROW [] +synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] +synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] +synonym: "natural killer cell inhibitory signalling pathway" EXACT [] +synonym: "NK cell inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002770 +name: T cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] +synonym: "T cell inhibitory signalling pathway" EXACT [] +synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] +synonym: "T-cell inhibitory signaling pathway" EXACT [] +synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002771 +name: inhibitory killer cell immunoglobulin-like receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] +synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] +synonym: "KIR signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002772 +name: inhibitory C-type lectin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] +synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] +synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002773 +name: B cell inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] +synonym: "B cell inhibitory signalling pathway" EXACT [] +synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] +synonym: "B-cell inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002774 +name: Fc receptor mediated inhibitory signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149] +synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] +synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] +is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway + +[Term] +id: GO:0002775 +name: antimicrobial peptide production +namespace: biological_process +def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response +relationship: part_of GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide + +[Term] +id: GO:0002776 +name: antimicrobial peptide secretion +namespace: biological_process +def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0002790 ! peptide secretion +relationship: part_of GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002777 +name: antimicrobial peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0043043 ! peptide biosynthetic process +relationship: part_of GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002778 +name: antibacterial peptide production +namespace: biological_process +def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002775 ! antimicrobial peptide production +relationship: part_of GO:0019731 ! antibacterial humoral response + +[Term] +id: GO:0002779 +name: antibacterial peptide secretion +namespace: biological_process +def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0002776 ! antimicrobial peptide secretion +relationship: part_of GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002780 +name: antibacterial peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0002777 ! antimicrobial peptide biosynthetic process +relationship: part_of GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002781 +name: antifungal peptide production +namespace: biological_process +def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002775 ! antimicrobial peptide production +relationship: part_of GO:0019732 ! antifungal humoral response + +[Term] +id: GO:0002782 +name: antifungal peptide secretion +namespace: biological_process +def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0002776 ! antimicrobial peptide secretion +relationship: part_of GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002783 +name: antifungal peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] +is_a: GO:0002777 ! antimicrobial peptide biosynthetic process +relationship: part_of GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002784 +name: regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +is_a: GO:0002759 ! regulation of antimicrobial humoral response +relationship: regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002785 +name: negative regulation of antimicrobial peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] +synonym: "down regulation of antimicrobial peptide production" EXACT [] +synonym: "down-regulation of antimicrobial peptide production" EXACT [] +synonym: "downregulation of antimicrobial peptide production" EXACT [] +synonym: "inhibition of antimicrobial peptide production" NARROW [] +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0008348 ! negative regulation of antimicrobial humoral response +relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production + +[Term] +id: GO:0002786 +name: regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +relationship: regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002787 +name: negative regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +synonym: "down regulation of antibacterial peptide production" EXACT [] +synonym: "down-regulation of antibacterial peptide production" EXACT [] +synonym: "downregulation of antibacterial peptide production" EXACT [] +synonym: "inhibition of antibacterial peptide production" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:1900425 ! negative regulation of defense response to bacterium +relationship: negatively_regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002788 +name: regulation of antifungal peptide production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:1900150 ! regulation of defense response to fungus +relationship: regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002789 +name: negative regulation of antifungal peptide production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] +synonym: "down regulation of antifungal peptide production" EXACT [] +synonym: "down-regulation of antifungal peptide production" EXACT [] +synonym: "downregulation of antifungal peptide production" EXACT [] +synonym: "inhibition of antifungal peptide production" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0031348 ! negative regulation of defense response +relationship: negatively_regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002790 +name: peptide secretion +namespace: biological_process +def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] +is_a: GO:0015833 ! peptide transport +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0002791 +name: regulation of peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0090087 ! regulation of peptide transport +relationship: regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002792 +name: negative regulation of peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] +synonym: "down regulation of peptide secretion" EXACT [] +synonym: "down-regulation of peptide secretion" EXACT [] +synonym: "downregulation of peptide secretion" EXACT [] +synonym: "inhibition of peptide secretion" NARROW [] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0051048 ! negative regulation of secretion +relationship: negatively_regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002793 +name: positive regulation of peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] +synonym: "activation of peptide secretion" NARROW [] +synonym: "stimulation of peptide secretion" NARROW [] +synonym: "up regulation of peptide secretion" EXACT [] +synonym: "up-regulation of peptide secretion" EXACT [] +synonym: "upregulation of peptide secretion" EXACT [] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0051047 ! positive regulation of secretion +relationship: positively_regulates GO:0002790 ! peptide secretion + +[Term] +id: GO:0002794 +name: regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0002791 ! regulation of peptide secretion +relationship: regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002795 +name: negative regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +synonym: "down regulation of antimicrobial peptide secretion" EXACT [] +synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] +synonym: "downregulation of antimicrobial peptide secretion" EXACT [] +synonym: "inhibition of antimicrobial peptide secretion" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002796 +name: positive regulation of antimicrobial peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] +synonym: "activation of antimicrobial peptide secretion" NARROW [] +synonym: "stimulation of antimicrobial peptide secretion" NARROW [] +synonym: "up regulation of antimicrobial peptide secretion" EXACT [] +synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] +synonym: "upregulation of antimicrobial peptide secretion" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion + +[Term] +id: GO:0002797 +name: regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002798 +name: negative regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +synonym: "down regulation of antibacterial peptide secretion" EXACT [] +synonym: "down-regulation of antibacterial peptide secretion" EXACT [] +synonym: "downregulation of antibacterial peptide secretion" EXACT [] +synonym: "inhibition of antibacterial peptide secretion" NARROW [] +is_a: GO:0002787 ! negative regulation of antibacterial peptide production +is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion +is_a: GO:0002797 ! regulation of antibacterial peptide secretion +relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002799 +name: positive regulation of antibacterial peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] +synonym: "activation of antibacterial peptide secretion" NARROW [] +synonym: "stimulation of antibacterial peptide secretion" NARROW [] +synonym: "up regulation of antibacterial peptide secretion" EXACT [] +synonym: "up-regulation of antibacterial peptide secretion" EXACT [] +synonym: "upregulation of antibacterial peptide secretion" EXACT [] +is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion +is_a: GO:0002797 ! regulation of antibacterial peptide secretion +is_a: GO:0002803 ! positive regulation of antibacterial peptide production +relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion + +[Term] +id: GO:0002800 +name: regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0002794 ! regulation of antimicrobial peptide secretion +relationship: regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002801 +name: negative regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +synonym: "down regulation of antifungal peptide secretion" EXACT [] +synonym: "down-regulation of antifungal peptide secretion" EXACT [] +synonym: "downregulation of antifungal peptide secretion" EXACT [] +synonym: "inhibition of antifungal peptide secretion" NARROW [] +is_a: GO:0002789 ! negative regulation of antifungal peptide production +is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion +is_a: GO:0002800 ! regulation of antifungal peptide secretion +relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002802 +name: positive regulation of antifungal peptide secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] +synonym: "activation of antifungal peptide secretion" NARROW [] +synonym: "stimulation of antifungal peptide secretion" NARROW [] +synonym: "up regulation of antifungal peptide secretion" EXACT [] +synonym: "up-regulation of antifungal peptide secretion" EXACT [] +synonym: "upregulation of antifungal peptide secretion" EXACT [] +is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion +is_a: GO:0002800 ! regulation of antifungal peptide secretion +is_a: GO:0002804 ! positive regulation of antifungal peptide production +relationship: positively_regulates GO:0002782 ! antifungal peptide secretion + +[Term] +id: GO:0002803 +name: positive regulation of antibacterial peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] +synonym: "activation of antibacterial peptide production" NARROW [] +synonym: "stimulation of antibacterial peptide production" NARROW [] +synonym: "up regulation of antibacterial peptide production" EXACT [] +synonym: "up-regulation of antibacterial peptide production" EXACT [] +synonym: "upregulation of antibacterial peptide production" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:1900426 ! positive regulation of defense response to bacterium +relationship: positively_regulates GO:0002778 ! antibacterial peptide production + +[Term] +id: GO:0002804 +name: positive regulation of antifungal peptide production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] +synonym: "activation of antifungal peptide production" NARROW [] +synonym: "stimulation of antifungal peptide production" NARROW [] +synonym: "up regulation of antifungal peptide production" EXACT [] +synonym: "up-regulation of antifungal peptide production" EXACT [] +synonym: "upregulation of antifungal peptide production" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0031349 ! positive regulation of defense response +relationship: positively_regulates GO:0002781 ! antifungal peptide production + +[Term] +id: GO:0002805 +name: regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +is_a: GO:0002784 ! regulation of antimicrobial peptide production +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002806 +name: negative regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] +is_a: GO:0002785 ! negative regulation of antimicrobial peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002807 +name: positive regulation of antimicrobial peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] +synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] +synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] +synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] +synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] +is_a: GO:0002225 ! positive regulation of antimicrobial peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process + +[Term] +id: GO:0002808 +name: regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] +is_a: GO:0002786 ! regulation of antibacterial peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0002809 +name: negative regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] +synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] +is_a: GO:0002787 ! negative regulation of antibacterial peptide production +is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0002810 +name: regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] +is_a: GO:0002788 ! regulation of antifungal peptide production +is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process +relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0002811 +name: negative regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] +synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] +is_a: GO:0002789 ! negative regulation of antifungal peptide production +is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process +relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0002812 +name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] +is_a: GO:0002780 ! antibacterial peptide biosynthetic process +relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium + +[Term] +id: GO:0002813 +name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0002814 +name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] +synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process +is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0002815 +name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] +is_a: GO:0002780 ! antibacterial peptide biosynthetic process +relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium + +[Term] +id: GO:0002816 +name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0002817 +name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] +synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process +is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0002819 +name: regulation of adaptive immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002820 +name: negative regulation of adaptive immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] +synonym: "down regulation of adaptive immune response" EXACT [] +synonym: "down-regulation of adaptive immune response" EXACT [] +synonym: "downregulation of adaptive immune response" EXACT [] +synonym: "inhibition of adaptive immune response" NARROW [] +is_a: GO:0002819 ! regulation of adaptive immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002821 +name: positive regulation of adaptive immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] +synonym: "activation of adaptive immune response" NARROW [] +synonym: "stimulation of adaptive immune response" NARROW [] +synonym: "up regulation of adaptive immune response" EXACT [] +synonym: "up-regulation of adaptive immune response" EXACT [] +synonym: "upregulation of adaptive immune response" EXACT [] +is_a: GO:0002819 ! regulation of adaptive immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0002822 +name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] +is_a: GO:0002819 ! regulation of adaptive immune response +relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002823 +name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] +is_a: GO:0002820 ! negative regulation of adaptive immune response +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002824 +name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] +is_a: GO:0002821 ! positive regulation of adaptive immune response +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0002825 +name: regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002826 +name: negative regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +synonym: "down regulation of T-helper 1 type immune response" EXACT [] +synonym: "down-regulation of T-helper 1 type immune response" EXACT [] +synonym: "downregulation of T-helper 1 type immune response" EXACT [] +synonym: "inhibition of T-helper 1 type immune response" NARROW [] +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002827 +name: positive regulation of T-helper 1 type immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] +synonym: "activation of T-helper 1 type immune response" NARROW [] +synonym: "stimulation of T-helper 1 type immune response" NARROW [] +synonym: "up regulation of T-helper 1 type immune response" EXACT [] +synonym: "up-regulation of T-helper 1 type immune response" EXACT [] +synonym: "upregulation of T-helper 1 type immune response" EXACT [] +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0002828 +name: regulation of type 2 immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] +synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] +synonym: "regulation of Th2 immune response" NARROW [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0042092 ! type 2 immune response + +[Term] +id: GO:0002829 +name: negative regulation of type 2 immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] +synonym: "down regulation of type 2 immune response" EXACT [] +synonym: "down-regulation of type 2 immune response" EXACT [] +synonym: "downregulation of type 2 immune response" EXACT [] +synonym: "inhibition of type 2 immune response" NARROW [] +synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] +synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] +is_a: GO:0002828 ! regulation of type 2 immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0042092 ! type 2 immune response + +[Term] +id: GO:0002830 +name: positive regulation of type 2 immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] +synonym: "activation of type 2 immune response" NARROW [] +synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] +synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] +synonym: "stimulation of type 2 immune response" NARROW [] +synonym: "up regulation of type 2 immune response" EXACT [] +synonym: "up-regulation of type 2 immune response" EXACT [] +synonym: "upregulation of type 2 immune response" EXACT [] +is_a: GO:0002828 ! regulation of type 2 immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0042092 ! type 2 immune response + +[Term] +id: GO:0002831 +name: regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002832 +name: negative regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "down regulation of response to biotic stimulus" EXACT [] +synonym: "down-regulation of response to biotic stimulus" EXACT [] +synonym: "downregulation of response to biotic stimulus" EXACT [] +synonym: "inhibition of response to biotic stimulus" NARROW [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002833 +name: positive regulation of response to biotic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "activation of response to biotic stimulus" NARROW [] +synonym: "stimulation of response to biotic stimulus" NARROW [] +synonym: "up regulation of response to biotic stimulus" EXACT [] +synonym: "up-regulation of response to biotic stimulus" EXACT [] +synonym: "upregulation of response to biotic stimulus" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0002834 +name: regulation of response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "regulation of response to tumour cell" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +relationship: regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002835 +name: negative regulation of response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "down regulation of response to tumor cell" EXACT [] +synonym: "down-regulation of response to tumor cell" EXACT [] +synonym: "downregulation of response to tumor cell" EXACT [] +synonym: "inhibition of response to tumor cell" NARROW [] +synonym: "negative regulation of response to tumour cell" EXACT [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0002834 ! regulation of response to tumor cell +relationship: negatively_regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002836 +name: positive regulation of response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] +synonym: "activation of response to tumor cell" NARROW [] +synonym: "positive regulation of response to tumour cell" EXACT [] +synonym: "stimulation of response to tumor cell" NARROW [] +synonym: "up regulation of response to tumor cell" EXACT [] +synonym: "up-regulation of response to tumor cell" EXACT [] +synonym: "upregulation of response to tumor cell" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0002834 ! regulation of response to tumor cell +relationship: positively_regulates GO:0002347 ! response to tumor cell + +[Term] +id: GO:0002837 +name: regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "regulation of immune response to tumour cell" EXACT [] +is_a: GO:0002834 ! regulation of response to tumor cell +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002838 +name: negative regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "down regulation of immune response to tumor cell" EXACT [] +synonym: "down-regulation of immune response to tumor cell" EXACT [] +synonym: "downregulation of immune response to tumor cell" EXACT [] +synonym: "inhibition of immune response to tumor cell" NARROW [] +synonym: "negative regulation of immune response to tumour cell" EXACT [] +is_a: GO:0002835 ! negative regulation of response to tumor cell +is_a: GO:0002837 ! regulation of immune response to tumor cell +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002839 +name: positive regulation of immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] +synonym: "activation of immune response to tumor cell" NARROW [] +synonym: "positive regulation of immune response to tumour cell" EXACT [] +synonym: "stimulation of immune response to tumor cell" NARROW [] +synonym: "up regulation of immune response to tumor cell" EXACT [] +synonym: "up-regulation of immune response to tumor cell" EXACT [] +synonym: "upregulation of immune response to tumor cell" EXACT [] +is_a: GO:0002836 ! positive regulation of response to tumor cell +is_a: GO:0002837 ! regulation of immune response to tumor cell +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002418 ! immune response to tumor cell + +[Term] +id: GO:0002840 +name: regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +is_a: GO:0002709 ! regulation of T cell mediated immunity +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002841 +name: negative regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] +synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002842 +name: positive regulation of T cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] +synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] +synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] +synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] +synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] +synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] +synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] +synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell + +[Term] +id: GO:0002843 +name: regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "regulation of tolerance induction to tumour cell" EXACT [] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002844 +name: negative regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "down regulation of tolerance induction to tumor cell" EXACT [] +synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] +synonym: "downregulation of tolerance induction to tumor cell" EXACT [] +synonym: "inhibition of tolerance induction to tumor cell" NARROW [] +synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002845 +name: positive regulation of tolerance induction to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] +synonym: "activation of tolerance induction to tumor cell" NARROW [] +synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] +synonym: "stimulation of tolerance induction to tumor cell" NARROW [] +synonym: "up regulation of tolerance induction to tumor cell" EXACT [] +synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] +synonym: "upregulation of tolerance induction to tumor cell" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell + +[Term] +id: GO:0002846 +name: regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +is_a: GO:0002843 ! regulation of tolerance induction to tumor cell +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002847 +name: negative regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] +is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell +is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell +is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell +is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction +relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002848 +name: positive regulation of T cell tolerance induction to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] +synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] +synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] +synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] +synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] +is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell +is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell +is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell +is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction +relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell + +[Term] +id: GO:0002849 +name: regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002664 ! regulation of T cell tolerance induction +is_a: GO:0002709 ! regulation of T cell mediated immunity +relationship: regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002850 +name: negative regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] +synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002665 ! negative regulation of T cell tolerance induction +is_a: GO:0002710 ! negative regulation of T cell mediated immunity +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002851 +name: positive regulation of peripheral T cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] +synonym: "activation of peripheral T cell tolerance induction" NARROW [] +synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] +synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] +synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002666 ! positive regulation of T cell tolerance induction +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction +relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction + +[Term] +id: GO:0002852 +name: regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell +relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002853 +name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity +is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell +is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target +relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002854 +name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] +synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity +is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell +is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target +relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002855 +name: regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +is_a: GO:0002837 ! regulation of immune response to tumor cell +relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002856 +name: negative regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0002838 ! negative regulation of immune response to tumor cell +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002857 +name: positive regulation of natural killer cell mediated immune response to tumor cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] +synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] +synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] +synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] +synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0002839 ! positive regulation of immune response to tumor cell +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell + +[Term] +id: GO:0002858 +name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002859 +name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity +relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002860 +name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] +synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] +synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] +is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell +is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target +is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity +relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target + +[Term] +id: GO:0002861 +name: regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002862 +name: negative regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002863 +name: positive regulation of inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus + +[Term] +id: GO:0002864 +name: regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002865 +name: negative regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002866 +name: positive regulation of acute inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus + +[Term] +id: GO:0002867 +name: regulation of B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "regulation of B lymphocyte deletion" EXACT [] +synonym: "regulation of B-cell deletion" EXACT [] +synonym: "regulation of B-lymphocyte deletion" EXACT [] +is_a: GO:0002661 ! regulation of B cell tolerance induction +is_a: GO:0002902 ! regulation of B cell apoptotic process +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002868 +name: negative regulation of B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "down regulation of B cell deletion" EXACT [] +synonym: "down-regulation of B cell deletion" EXACT [] +synonym: "downregulation of B cell deletion" EXACT [] +synonym: "inhibition of B cell deletion" NARROW [] +synonym: "negative regulation of B lymphocyte deletion" EXACT [] +synonym: "negative regulation of B-cell deletion" EXACT [] +synonym: "negative regulation of B-lymphocyte deletion" EXACT [] +is_a: GO:0002662 ! negative regulation of B cell tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002903 ! negative regulation of B cell apoptotic process +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +relationship: negatively_regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002869 +name: positive regulation of B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] +synonym: "activation of B cell deletion" NARROW [] +synonym: "positive regulation of B lymphocyte deletion" EXACT [] +synonym: "positive regulation of B-cell deletion" EXACT [] +synonym: "positive regulation of B-lymphocyte deletion" EXACT [] +synonym: "stimulation of B cell deletion" NARROW [] +synonym: "up regulation of B cell deletion" EXACT [] +synonym: "up-regulation of B cell deletion" EXACT [] +synonym: "upregulation of B cell deletion" EXACT [] +is_a: GO:0002663 ! positive regulation of B cell tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002904 ! positive regulation of B cell apoptotic process +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +relationship: positively_regulates GO:0002516 ! B cell deletion + +[Term] +id: GO:0002870 +name: T cell anergy +namespace: biological_process +def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149] +synonym: "T lymphocyte anergy" EXACT [] +synonym: "T-cell anergy" EXACT [] +synonym: "T-lymphocyte anergy" EXACT [] +is_a: GO:0002249 ! lymphocyte anergy +is_a: GO:0002517 ! T cell tolerance induction + +[Term] +id: GO:0002871 +name: regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "regulation of NK cell tolerance induction" EXACT [] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002872 +name: negative regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "down regulation of natural killer cell tolerance induction" EXACT [] +synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] +synonym: "downregulation of natural killer cell tolerance induction" EXACT [] +synonym: "inhibition of natural killer cell tolerance induction" NARROW [] +synonym: "negative regulation of NK cell tolerance induction" EXACT [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002871 ! regulation of natural killer cell tolerance induction +relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002873 +name: positive regulation of natural killer cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] +synonym: "activation of natural killer cell tolerance induction" NARROW [] +synonym: "positive regulation of NK cell tolerance induction" EXACT [] +synonym: "stimulation of natural killer cell tolerance induction" NARROW [] +synonym: "up regulation of natural killer cell tolerance induction" EXACT [] +synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] +synonym: "upregulation of natural killer cell tolerance induction" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0002871 ! regulation of natural killer cell tolerance induction +relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction + +[Term] +id: GO:0002874 +name: regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus +relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002875 +name: negative regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] +is_a: GO:0002677 ! negative regulation of chronic inflammatory response +is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus +is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus +relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002876 +name: positive regulation of chronic inflammatory response to antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] +synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] +synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] +synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] +synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] +is_a: GO:0002678 ! positive regulation of chronic inflammatory response +is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus +is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus +relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus + +[Term] +id: GO:0002877 +name: regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +is_a: GO:0002673 ! regulation of acute inflammatory response +relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002878 +name: negative regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus +relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002879 +name: positive regulation of acute inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus +relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002880 +name: regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +is_a: GO:0002676 ! regulation of chronic inflammatory response +relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002881 +name: negative regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] +is_a: GO:0002677 ! negative regulation of chronic inflammatory response +is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus +relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002882 +name: positive regulation of chronic inflammatory response to non-antigenic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] +synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] +synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] +is_a: GO:0002678 ! positive regulation of chronic inflammatory response +is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus +relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus + +[Term] +id: GO:0002883 +name: regulation of hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] +is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus +relationship: regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002884 +name: negative regulation of hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] +synonym: "down regulation of hypersensitivity" EXACT [] +synonym: "down-regulation of hypersensitivity" EXACT [] +synonym: "downregulation of hypersensitivity" EXACT [] +synonym: "inhibition of hypersensitivity" NARROW [] +is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: negatively_regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002885 +name: positive regulation of hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] +synonym: "activation of hypersensitivity" NARROW [] +synonym: "stimulation of hypersensitivity" NARROW [] +synonym: "up regulation of hypersensitivity" EXACT [] +synonym: "up-regulation of hypersensitivity" EXACT [] +synonym: "upregulation of hypersensitivity" EXACT [] +is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus +is_a: GO:0002883 ! regulation of hypersensitivity +relationship: positively_regulates GO:0002524 ! hypersensitivity + +[Term] +id: GO:0002886 +name: regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +is_a: GO:0002703 ! regulation of leukocyte mediated immunity +relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002887 +name: negative regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] +is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002888 +name: positive regulation of myeloid leukocyte mediated immunity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] +synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] +synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] +synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] +synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] +is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0002889 +name: regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002890 +name: negative regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] +synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002891 +name: positive regulation of immunoglobulin mediated immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] +synonym: "activation of immunoglobulin mediated immune response" NARROW [] +synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] +synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] +synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0002892 +name: regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +is_a: GO:0002883 ! regulation of hypersensitivity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002893 +name: negative regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +synonym: "down regulation of type II hypersensitivity" EXACT [] +synonym: "down-regulation of type II hypersensitivity" EXACT [] +synonym: "downregulation of type II hypersensitivity" EXACT [] +synonym: "inhibition of type II hypersensitivity" NARROW [] +is_a: GO:0002884 ! negative regulation of hypersensitivity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: negatively_regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002894 +name: positive regulation of type II hypersensitivity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] +synonym: "activation of type II hypersensitivity" NARROW [] +synonym: "stimulation of type II hypersensitivity" NARROW [] +synonym: "up regulation of type II hypersensitivity" EXACT [] +synonym: "up-regulation of type II hypersensitivity" EXACT [] +synonym: "upregulation of type II hypersensitivity" EXACT [] +is_a: GO:0002885 ! positive regulation of hypersensitivity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:0002892 ! regulation of type II hypersensitivity +relationship: positively_regulates GO:0002445 ! type II hypersensitivity + +[Term] +id: GO:0002895 +name: regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +is_a: GO:0002646 ! regulation of central tolerance induction +is_a: GO:0002661 ! regulation of B cell tolerance induction +relationship: regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002896 +name: negative regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +synonym: "down regulation of central B cell tolerance induction" EXACT [] +synonym: "down-regulation of central B cell tolerance induction" EXACT [] +synonym: "downregulation of central B cell tolerance induction" EXACT [] +synonym: "inhibition of central B cell tolerance induction" NARROW [] +is_a: GO:0002647 ! negative regulation of central tolerance induction +is_a: GO:0002662 ! negative regulation of B cell tolerance induction +is_a: GO:0002895 ! regulation of central B cell tolerance induction +relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002897 +name: positive regulation of central B cell tolerance induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] +synonym: "activation of central B cell tolerance induction" NARROW [] +synonym: "stimulation of central B cell tolerance induction" NARROW [] +synonym: "up regulation of central B cell tolerance induction" EXACT [] +synonym: "up-regulation of central B cell tolerance induction" EXACT [] +synonym: "upregulation of central B cell tolerance induction" EXACT [] +is_a: GO:0002648 ! positive regulation of central tolerance induction +is_a: GO:0002663 ! positive regulation of B cell tolerance induction +is_a: GO:0002895 ! regulation of central B cell tolerance induction +relationship: positively_regulates GO:0002510 ! central B cell tolerance induction + +[Term] +id: GO:0002898 +name: regulation of central B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] +is_a: GO:0002867 ! regulation of B cell deletion +is_a: GO:0002895 ! regulation of central B cell tolerance induction +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002899 +name: negative regulation of central B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] +synonym: "down regulation of central B cell deletion" EXACT [] +synonym: "down-regulation of central B cell deletion" EXACT [] +synonym: "downregulation of central B cell deletion" EXACT [] +synonym: "inhibition of central B cell deletion" NARROW [] +is_a: GO:0002868 ! negative regulation of B cell deletion +is_a: GO:0002896 ! negative regulation of central B cell tolerance induction +is_a: GO:0002898 ! regulation of central B cell deletion +is_a: GO:0045578 ! negative regulation of B cell differentiation +relationship: negatively_regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002900 +name: positive regulation of central B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] +synonym: "activation of central B cell deletion" NARROW [] +synonym: "stimulation of central B cell deletion" NARROW [] +synonym: "up regulation of central B cell deletion" EXACT [] +synonym: "up-regulation of central B cell deletion" EXACT [] +synonym: "upregulation of central B cell deletion" EXACT [] +is_a: GO:0002869 ! positive regulation of B cell deletion +is_a: GO:0002897 ! positive regulation of central B cell tolerance induction +is_a: GO:0002898 ! regulation of central B cell deletion +is_a: GO:0045579 ! positive regulation of B cell differentiation +relationship: positively_regulates GO:0002342 ! central B cell deletion + +[Term] +id: GO:0002901 +name: mature B cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] +synonym: "apoptosis of mature B cells" EXACT [] +synonym: "apoptosis of mature B lymphocytes" EXACT [] +synonym: "apoptosis of mature B-cells" EXACT [] +synonym: "apoptosis of mature B-lymphocytes" EXACT [] +synonym: "mature B cell apoptosis" NARROW [] +synonym: "mature B cell programmed cell death by apoptosis" EXACT [] +synonym: "mature B lymphocyte apoptosis" EXACT [] +synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "mature B-cell apoptosis" EXACT [] +synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] +synonym: "mature B-lymphocyte apoptosis" EXACT [] +synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] +synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] +synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] +synonym: "programmed cell death, mature B cells" EXACT [] +synonym: "programmed cell death, mature B lymphocytes" EXACT [] +synonym: "programmed cell death, mature B-cells" EXACT [] +synonym: "programmed cell death, mature B-lymphocytes" EXACT [] +is_a: GO:0001783 ! B cell apoptotic process +relationship: part_of GO:0001782 ! B cell homeostasis + +[Term] +id: GO:0002902 +name: regulation of B cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "regulation of B cell apoptosis" NARROW [] +is_a: GO:0070228 ! regulation of lymphocyte apoptotic process +relationship: regulates GO:0001783 ! B cell apoptotic process + +[Term] +id: GO:0002903 +name: negative regulation of B cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "down regulation of B cell apoptosis" EXACT [] +synonym: "down-regulation of B cell apoptosis" EXACT [] +synonym: "downregulation of B cell apoptosis" EXACT [] +synonym: "inhibition of B cell apoptosis" NARROW [] +synonym: "negative regulation of B cell apoptosis" NARROW [] +is_a: GO:0002902 ! regulation of B cell apoptotic process +is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process +relationship: negatively_regulates GO:0001783 ! B cell apoptotic process + +[Term] +id: GO:0002904 +name: positive regulation of B cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "activation of B cell apoptosis" NARROW [] +synonym: "positive regulation of B cell apoptosis" NARROW [] +synonym: "stimulation of B cell apoptosis" NARROW [] +synonym: "up regulation of B cell apoptosis" EXACT [] +synonym: "up-regulation of B cell apoptosis" EXACT [] +synonym: "upregulation of B cell apoptosis" EXACT [] +is_a: GO:0002902 ! regulation of B cell apoptotic process +is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process +relationship: positively_regulates GO:0001783 ! B cell apoptotic process + +[Term] +id: GO:0002905 +name: regulation of mature B cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "regulation of mature B cell apoptosis" NARROW [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0002902 ! regulation of B cell apoptotic process +relationship: regulates GO:0002901 ! mature B cell apoptotic process + +[Term] +id: GO:0002906 +name: negative regulation of mature B cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "down regulation of mature B cell apoptosis" EXACT [] +synonym: "down-regulation of mature B cell apoptosis" EXACT [] +synonym: "downregulation of mature B cell apoptosis" EXACT [] +synonym: "inhibition of mature B cell apoptosis" NARROW [] +synonym: "negative regulation of mature B cell apoptosis" NARROW [] +is_a: GO:0002903 ! negative regulation of B cell apoptotic process +is_a: GO:0002905 ! regulation of mature B cell apoptotic process +relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process + +[Term] +id: GO:0002907 +name: positive regulation of mature B cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "activation of mature B cell apoptosis" NARROW [] +synonym: "positive regulation of mature B cell apoptosis" NARROW [] +synonym: "stimulation of mature B cell apoptosis" NARROW [] +synonym: "up regulation of mature B cell apoptosis" EXACT [] +synonym: "up-regulation of mature B cell apoptosis" EXACT [] +synonym: "upregulation of mature B cell apoptosis" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0002904 ! positive regulation of B cell apoptotic process +is_a: GO:0002905 ! regulation of mature B cell apoptotic process +relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process + +[Term] +id: GO:0002908 +name: regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002712 ! regulation of B cell mediated immunity +is_a: GO:0002867 ! regulation of B cell deletion +relationship: regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002909 +name: negative regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +synonym: "down regulation of peripheral B cell deletion" EXACT [] +synonym: "down-regulation of peripheral B cell deletion" EXACT [] +synonym: "downregulation of peripheral B cell deletion" EXACT [] +synonym: "inhibition of peripheral B cell deletion" NARROW [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002868 ! negative regulation of B cell deletion +is_a: GO:0002908 ! regulation of peripheral B cell deletion +relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002910 +name: positive regulation of peripheral B cell deletion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] +synonym: "activation of peripheral B cell deletion" NARROW [] +synonym: "stimulation of peripheral B cell deletion" NARROW [] +synonym: "up regulation of peripheral B cell deletion" EXACT [] +synonym: "up-regulation of peripheral B cell deletion" EXACT [] +synonym: "upregulation of peripheral B cell deletion" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002869 ! positive regulation of B cell deletion +is_a: GO:0002908 ! regulation of peripheral B cell deletion +relationship: positively_regulates GO:0002454 ! peripheral B cell deletion + +[Term] +id: GO:0002911 +name: regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002912 +name: negative regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +synonym: "down regulation of lymphocyte anergy" EXACT [] +synonym: "down-regulation of lymphocyte anergy" EXACT [] +synonym: "downregulation of lymphocyte anergy" EXACT [] +synonym: "inhibition of lymphocyte anergy" NARROW [] +is_a: GO:0002644 ! negative regulation of tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: negatively_regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002913 +name: positive regulation of lymphocyte anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] +synonym: "activation of lymphocyte anergy" NARROW [] +synonym: "stimulation of lymphocyte anergy" NARROW [] +synonym: "up regulation of lymphocyte anergy" EXACT [] +synonym: "up-regulation of lymphocyte anergy" EXACT [] +synonym: "upregulation of lymphocyte anergy" EXACT [] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0002911 ! regulation of lymphocyte anergy +relationship: positively_regulates GO:0002249 ! lymphocyte anergy + +[Term] +id: GO:0002914 +name: regulation of central B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002895 ! regulation of central B cell tolerance induction +is_a: GO:0045577 ! regulation of B cell differentiation +relationship: regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002915 +name: negative regulation of central B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] +synonym: "down regulation of central B cell anergy" EXACT [] +synonym: "down-regulation of central B cell anergy" EXACT [] +synonym: "downregulation of central B cell anergy" EXACT [] +synonym: "inhibition of central B cell anergy" NARROW [] +is_a: GO:0002671 ! negative regulation of B cell anergy +is_a: GO:0002896 ! negative regulation of central B cell tolerance induction +is_a: GO:0002914 ! regulation of central B cell anergy +is_a: GO:0045578 ! negative regulation of B cell differentiation +relationship: negatively_regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002916 +name: positive regulation of central B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] +synonym: "activation of central B cell anergy" NARROW [] +synonym: "stimulation of central B cell anergy" NARROW [] +synonym: "up regulation of central B cell anergy" EXACT [] +synonym: "up-regulation of central B cell anergy" EXACT [] +synonym: "upregulation of central B cell anergy" EXACT [] +is_a: GO:0002672 ! positive regulation of B cell anergy +is_a: GO:0002897 ! positive regulation of central B cell tolerance induction +is_a: GO:0002914 ! regulation of central B cell anergy +is_a: GO:0045579 ! positive regulation of B cell differentiation +relationship: positively_regulates GO:0002341 ! central B cell anergy + +[Term] +id: GO:0002917 +name: regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +is_a: GO:0002658 ! regulation of peripheral tolerance induction +is_a: GO:0002670 ! regulation of B cell anergy +is_a: GO:0002712 ! regulation of B cell mediated immunity +relationship: regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002918 +name: negative regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +synonym: "down regulation of peripheral B cell anergy" EXACT [] +synonym: "down-regulation of peripheral B cell anergy" EXACT [] +synonym: "downregulation of peripheral B cell anergy" EXACT [] +synonym: "inhibition of peripheral B cell anergy" NARROW [] +is_a: GO:0002659 ! negative regulation of peripheral tolerance induction +is_a: GO:0002671 ! negative regulation of B cell anergy +is_a: GO:0002713 ! negative regulation of B cell mediated immunity +is_a: GO:0002917 ! regulation of peripheral B cell anergy +relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002919 +name: positive regulation of peripheral B cell anergy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] +synonym: "activation of peripheral B cell anergy" NARROW [] +synonym: "stimulation of peripheral B cell anergy" NARROW [] +synonym: "up regulation of peripheral B cell anergy" EXACT [] +synonym: "up-regulation of peripheral B cell anergy" EXACT [] +synonym: "upregulation of peripheral B cell anergy" EXACT [] +is_a: GO:0002660 ! positive regulation of peripheral tolerance induction +is_a: GO:0002672 ! positive regulation of B cell anergy +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0002917 ! regulation of peripheral B cell anergy +relationship: positively_regulates GO:0002453 ! peripheral B cell anergy + +[Term] +id: GO:0002920 +name: regulation of humoral immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002921 +name: negative regulation of humoral immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] +synonym: "down regulation of humoral immune response" EXACT [] +synonym: "down-regulation of humoral immune response" EXACT [] +synonym: "downregulation of humoral immune response" EXACT [] +synonym: "inhibition of humoral immune response" NARROW [] +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002922 +name: positive regulation of humoral immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] +synonym: "activation of humoral immune response" NARROW [] +synonym: "stimulation of humoral immune response" NARROW [] +synonym: "up regulation of humoral immune response" EXACT [] +synonym: "up-regulation of humoral immune response" EXACT [] +synonym: "upregulation of humoral immune response" EXACT [] +is_a: GO:0002920 ! regulation of humoral immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0006959 ! humoral immune response + +[Term] +id: GO:0002923 +name: regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +is_a: GO:0002920 ! regulation of humoral immune response +relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0002924 +name: negative regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0002925 +name: positive regulation of humoral immune response mediated by circulating immunoglobulin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] +synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] +synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] +synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0002926 +name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation +namespace: biological_process +def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988] +synonym: "mcm5 modification" EXACT [] +synonym: "mcm5s2U34 biosynthesis" EXACT [] +synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis" EXACT [] +is_a: GO:0002098 ! tRNA wobble uridine modification + +[Term] +id: GO:0002927 +name: archaeosine-tRNA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393] +comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. +is_a: GO:0006400 ! tRNA modification +is_a: GO:0009058 ! biosynthetic process + +[Term] +id: GO:0002929 +name: MECO complex +namespace: cellular_component +def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642] +synonym: "meta-coactivator complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0002930 +name: trabecular meshwork development +namespace: biological_process +def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0002931 +name: response to ischemia +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd] +comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia. +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0002932 +name: tendon sheath development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0035989 ! tendon development + +[Term] +id: GO:0002933 +name: lipid hydroxylation +namespace: biological_process +def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937] +synonym: "fatty acid hydroxylation" RELATED [] +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0002934 +name: desmosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0002935 +name: tRNA (adenine-C2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362] +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity + +[Term] +id: GO:0002936 +name: bradykinin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291] +is_a: GO:0043043 ! peptide biosynthetic process + +[Term] +id: GO:0002937 +name: tRNA 4-thiouridine biosynthesis +namespace: biological_process +def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X] +comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to an unidentified intermediate. NuvC also participates in thiamine synthesis. +is_a: GO:0034227 ! tRNA thio-modification + +[Term] +id: GO:0002938 +name: tRNA guanine ribose methylation +namespace: biological_process +def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:1555811337] +is_a: GO:0002128 ! tRNA nucleoside ribose methylation + +[Term] +id: GO:0002939 +name: tRNA N1-guanine methylation +namespace: biological_process +def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337] +synonym: "tRNA m1-guanine biosynthesis" RELATED [] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0002940 +name: tRNA N2-guanine methylation +namespace: biological_process +def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337] +synonym: "tRNA m2-guanine biosynthesis" RELATED [] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0002941 +name: synoviocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0002942 +name: tRNA m2,2-guanine biosynthesis +namespace: biological_process +def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:155581073X] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0002943 +name: tRNA dihydrouridine synthesis +namespace: biological_process +def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:155581073X] +comment: Dihydrouridine is found in numerous positions within loop I, the so-called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b. +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0002944 +name: cyclin K-CDK12 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] +synonym: "CycK/Cdk12 complex" RELATED [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0002945 +name: cyclin K-CDK13 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] +synonym: "CycK/Cdk13 complex" RELATED [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0002946 +name: tRNA C5-cytosine methylation +namespace: biological_process +def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:155581073X] +synonym: "tRNA 5-methylcytosine biosynthesis" RELATED [] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0002947 +name: tumor necrosis factor receptor superfamily complex +namespace: cellular_component +def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc] +synonym: "TNF receptor superfamily complex" RELATED [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0002948 +name: archaeosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, RHEA:54084] +synonym: "ArcS" RELATED [] +synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED [] +xref: EC:2.6.1.97 +xref: RHEA:54084 +xref: Wikipedia:Archaeosine_synthase +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0002949 +name: tRNA threonylcarbamoyladenosine modification +namespace: biological_process +alt_id: GO:0070526 +def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706] +synonym: "t6A biosynthesis" EXACT [PMID:19287007] +synonym: "t6A biosynthetic process" EXACT [PMID:19287007] +synonym: "t6A tRNA modification" EXACT [] +synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah] +synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah] +synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT [] +synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah] +synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process + +[Term] +id: GO:0002950 +name: ceramide phosphoethanolamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine." [EC:2.7.8.n3, PMID:25667419] +xref: Reactome:R-HSA-8959462 "SAMD8 transforms PE and CERA to CPE" +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0002951 +name: leukotriene-C(4) hydrolase +namespace: molecular_function +def: "Catalysis of the reaction Leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate." [EC:3.4.19.14, PMID:9774450] +comment: The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione. +is_a: GO:0070122 ! isopeptidase activity + +[Term] +id: GO:0002952 +name: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione." [EC:5.3.1.32] +synonym: "phospho-AI-2 isomerase activity" RELATED [] +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0002953 +name: 5'-deoxynucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate." [EC:3.1.3.89] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0003001 +name: obsolete generation of a signal involved in cell-cell signaling +namespace: biological_process +def: "OBSOLETE. The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] +comment: This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling. +synonym: "formation of a signal" BROAD [] +synonym: "generation of a signal involved in cell-cell signaling" EXACT [] +synonym: "generation of a signal involved in cell-cell signalling" EXACT [] +synonym: "signal generation" BROAD [] +is_obsolete: true +consider: GO:0007267 +consider: GO:0010496 +consider: GO:0023061 +consider: GO:0031130 + +[Term] +id: GO:0003002 +name: regionalization +namespace: biological_process +def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] +synonym: "pattern formation" RELATED [GOC:dph] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0003003 +name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage +namespace: biological_process +def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] +synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048165 ! fused antrum stage + +[Term] +id: GO:0003004 +name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage +namespace: biological_process +def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] +synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048164 ! distinct antral spaces stage + +[Term] +id: GO:0003005 +name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage +namespace: biological_process +def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] +synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum +relationship: part_of GO:0048163 ! scattered antral spaces stage + +[Term] +id: GO:0003006 +name: developmental process involved in reproduction +namespace: biological_process +def: "A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] +synonym: "puberty" NARROW [GOC:dph] +synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022414 ! reproductive process +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0003007 +name: heart morphogenesis +namespace: biological_process +def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] +synonym: "cardiac morphogenesis" RELATED [] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003008 +name: system process +namespace: biological_process +def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] +synonym: "organ system process" EXACT [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0003009 +name: skeletal muscle contraction +namespace: biological_process +def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0006941 ! striated muscle contraction +relationship: part_of GO:0050881 ! musculoskeletal movement + +[Term] +id: GO:0003010 +name: voluntary skeletal muscle contraction +namespace: biological_process +def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0003011 +name: involuntary skeletal muscle contraction +namespace: biological_process +def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] +is_a: GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0003012 +name: muscle system process +namespace: biological_process +def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] +subset: goslim_drosophila +subset: goslim_generic +synonym: "muscle physiological process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003013 +name: circulatory system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] +subset: goslim_chembl +subset: goslim_generic +xref: Wikipedia:Circulatory_system +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003014 +name: renal system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] +subset: goslim_generic +synonym: "excretory system process" EXACT [] +synonym: "kidney system process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0003015 +name: heart process +namespace: biological_process +def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] +synonym: "cardiac process" RELATED [] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003016 +name: respiratory system process +namespace: biological_process +alt_id: GO:0010802 +def: "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] +subset: goslim_generic +synonym: "respiratory gaseous exchange" EXACT [] +is_a: GO:0003008 ! system process +relationship: part_of GO:0007585 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:0003017 +name: lymph circulation +namespace: biological_process +def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003018 +name: vascular process in circulatory system +namespace: biological_process +def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] +synonym: "vasculature process" EXACT [] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0003019 +name: central nervous system control of baroreceptor feedback +namespace: biological_process +def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback + +[Term] +id: GO:0003020 +name: detection of reduced oxygen by chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] +synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0070483 ! detection of hypoxia +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling + +[Term] +id: GO:0003021 +name: detection of increased carbon dioxide by chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] +synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003031 ! detection of carbon dioxide +relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling + +[Term] +id: GO:0003022 +name: detection of pH by chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951] +synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003030 ! detection of hydrogen ion + +[Term] +id: GO:0003023 +name: baroreceptor detection of increased arterial stretch +namespace: biological_process +def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] +is_a: GO:0001981 ! baroreceptor detection of arterial stretch +relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure + +[Term] +id: GO:0003024 +name: baroreceptor detection of decreased arterial stretch +namespace: biological_process +def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] +is_a: GO:0001981 ! baroreceptor detection of arterial stretch +relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure + +[Term] +id: GO:0003025 +name: regulation of systemic arterial blood pressure by baroreceptor feedback +namespace: biological_process +def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0003026 +name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback +namespace: biological_process +def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback + +[Term] +id: GO:0003027 +name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] +synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] +synonym: "vagal reflex" BROAD [] +is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling + +[Term] +id: GO:0003028 +name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] +synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling + +[Term] +id: GO:0003029 +name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] +synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling + +[Term] +id: GO:0003030 +name: detection of hydrogen ion +namespace: biological_process +def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003031 +name: detection of carbon dioxide +namespace: biological_process +def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0003032 +name: detection of oxygen +namespace: biological_process +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0070482 ! response to oxygen levels + +[Term] +id: GO:0003033 +name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] +synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling + +[Term] +id: GO:0003034 +name: detection of increased carbon dioxide by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling + +[Term] +id: GO:0003035 +name: detection of increased carbon dioxide by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling + +[Term] +id: GO:0003036 +name: detection of pH by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003022 ! detection of pH by chemoreceptor signaling +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling + +[Term] +id: GO:0003037 +name: detection of pH by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003022 ! detection of pH by chemoreceptor signaling +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling + +[Term] +id: GO:0003038 +name: detection of reduced oxygen by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] +synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling +relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling + +[Term] +id: GO:0003039 +name: detection of reduced oxygen by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] +synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling +relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling + +[Term] +id: GO:0003040 +name: excitation of vasomotor center by aortic body chemoreceptor signaling +namespace: biological_process +def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] +synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling + +[Term] +id: GO:0003041 +name: excitation of vasomotor center by carotid body chemoreceptor signaling +namespace: biological_process +def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] +synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] +is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling + +[Term] +id: GO:0003042 +name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951] +synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] +is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling + +[Term] +id: GO:0003043 +name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure +namespace: biological_process +def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] +synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] +is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure +relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling + +[Term] +id: GO:0003044 +name: regulation of systemic arterial blood pressure mediated by a chemical signal +namespace: biological_process +def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003045 +name: regulation of systemic arterial blood pressure by physical factors +namespace: biological_process +def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] +synonym: "blood pressure regulation by physical factors" EXACT [] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003046 +name: regulation of systemic arterial blood pressure by stress relaxation +namespace: biological_process +def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure regulation by stress relaxation" EXACT [] +is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure + +[Term] +id: GO:0003047 +name: regulation of systemic arterial blood pressure by epinephrine +namespace: biological_process +def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation by epinephrine" RELATED [] +synonym: "regulation of blood pressure by adrenaline" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0003048 +name: regulation of systemic arterial blood pressure by norepinephrine +namespace: biological_process +def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] +synonym: "blood pressure regulation by norepinephrine" RELATED [] +synonym: "regulation of blood pressure by noradrenaline" EXACT [] +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal +relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine + +[Term] +id: GO:0003049 +name: regulation of systemic arterial blood pressure by capillary fluid shift +namespace: biological_process +def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure regulation by capillary fluid shift" EXACT [] +is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors + +[Term] +id: GO:0003050 +name: regulation of systemic arterial blood pressure by atrial natriuretic peptide +namespace: biological_process +def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] +synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] +synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003051 +name: angiotensin-mediated drinking behavior +namespace: biological_process +def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] +synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042756 ! drinking behavior +relationship: part_of GO:0002035 ! brain renin-angiotensin system + +[Term] +id: GO:0003052 +name: circadian regulation of systemic arterial blood pressure +namespace: biological_process +def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0003053 +name: circadian regulation of heart rate +namespace: biological_process +def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "circadian regulation of heart contraction rate" RELATED [] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0003054 +name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus +namespace: biological_process +def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "master pacemaker clock regulation of blood pressure" EXACT [] +synonym: "SCN regulation of blood pressure" EXACT [] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure + +[Term] +id: GO:0003055 +name: circadian regulation of heart rate by the suprachiasmatic nucleus +namespace: biological_process +def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] +synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] +synonym: "master pacemaker clock regulation of heart rate" EXACT [] +synonym: "SCN regulation of heart rate" EXACT [] +is_a: GO:0003053 ! circadian regulation of heart rate + +[Term] +id: GO:0003056 +name: regulation of vascular associated smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] +synonym: "regulation of vascular smooth muscle contraction" EXACT [] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0019229 ! regulation of vasoconstriction +relationship: regulates GO:0014829 ! vascular associated smooth muscle contraction + +[Term] +id: GO:0003057 +name: regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] +synonym: "chemical cardiac inotropy" EXACT [] +synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] +is_a: GO:0002026 ! regulation of the force of heart contraction + +[Term] +id: GO:0003058 +name: hormonal regulation of the force of heart contraction +namespace: biological_process +def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] +synonym: "hormonal cardiac inotropy" EXACT [] +synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal + +[Term] +id: GO:0003059 +name: positive regulation of the force of heart contraction by epinephrine +namespace: biological_process +def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "adrenaline cardiac inotropy" EXACT [] +synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] +synonym: "epinephrine cardiac inotropy" EXACT [] +synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003060 +name: negative regulation of the force of heart contraction by acetylcholine +namespace: biological_process +def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "decreased force of heart contraction by acetylcholine" EXACT [] +is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine + +[Term] +id: GO:0003061 +name: positive regulation of the force of heart contraction by norepinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] +synonym: "increased force of heart contraction by adrenaline" RELATED [] +synonym: "increased force of heart contraction by norepinephrine" EXACT [] +synonym: "noradrenaline cardiac inotropy" EXACT [] +synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] +synonym: "norepinephrine cardiac inotropy" EXACT [] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] +is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal +relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003062 +name: regulation of heart rate by chemical signal +namespace: biological_process +def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] +synonym: "chemical cardiac chronotropy" EXACT [] +synonym: "chemical signal regulation of heart contraction rate" RELATED [] +synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate + +[Term] +id: GO:0003063 +name: negative regulation of heart rate by acetylcholine +namespace: biological_process +def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +is_a: GO:0010459 ! negative regulation of heart rate +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine + +[Term] +id: GO:0003064 +name: regulation of heart rate by hormone +namespace: biological_process +def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] +synonym: "hormonal cardiac chronotropy" EXACT [] +synonym: "regulation of the rate of heart contraction by hormone" EXACT [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal + +[Term] +id: GO:0003065 +name: positive regulation of heart rate by epinephrine +namespace: biological_process +def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "adrenaline cardiac chronotropy" EXACT [] +synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] +synonym: "epinephrine cardiac chronotropy" EXACT [] +synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] +synonym: "positive regulation of heart rate by adrenaline" RELATED [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine + +[Term] +id: GO:0003066 +name: positive regulation of heart rate by norepinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] +synonym: "noradrenaline cardiac chronotropy" EXACT [] +synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] +synonym: "norepinephrine cardiac chronotropy" EXACT [] +synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] +synonym: "positive regulation of heart rate by adrenaline" EXACT [] +is_a: GO:0003062 ! regulation of heart rate by chemical signal +is_a: GO:0010460 ! positive regulation of heart rate +relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine + +[Term] +id: GO:0003067 +name: circadian regulation of systemic arterial blood pressure by hormone +namespace: biological_process +def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone +relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure + +[Term] +id: GO:0003068 +name: regulation of systemic arterial blood pressure by acetylcholine +namespace: biological_process +def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] +synonym: "blood pressure regulation by acetylcholine" EXACT [] +is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter + +[Term] +id: GO:0003069 +name: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] +synonym: "vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure" EXACT [] +is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure +is_a: GO:0042311 ! vasodilation +relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine + +[Term] +id: GO:0003070 +name: regulation of systemic arterial blood pressure by neurotransmitter +namespace: biological_process +def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio] +is_a: GO:0001976 ! nervous system process involved in regulation of systemic arterial blood pressure +is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal + +[Term] +id: GO:0003071 +name: renal system process involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "renal control of blood pressure" EXACT [] +synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003014 ! renal system process +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003072 +name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] +synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] +synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0003073 +name: regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0003074 +name: obsolete regulation of diuresis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "regulation of diuresis" EXACT [] +is_obsolete: true +consider: GO:0035809 + +[Term] +id: GO:0003075 +name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure +namespace: biological_process +def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] +synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure + +[Term] +id: GO:0003077 +name: obsolete negative regulation of diuresis +namespace: biological_process +def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "negative regulation of diuresis" EXACT [] +is_obsolete: true +consider: GO:0035811 + +[Term] +id: GO:0003078 +name: obsolete regulation of natriuresis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "regulation of natriuresis" EXACT [] +is_obsolete: true +consider: GO:0035813 + +[Term] +id: GO:0003079 +name: obsolete positive regulation of natriuresis +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "positive regulation of natriuresis" EXACT [] +is_obsolete: true +consider: GO:0035815 + +[Term] +id: GO:0003080 +name: obsolete negative regulation of natriuresis +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "negative regulation of natriuresis" EXACT [] +is_obsolete: true +consider: GO:0035814 + +[Term] +id: GO:0003081 +name: regulation of systemic arterial blood pressure by renin-angiotensin +namespace: biological_process +def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] +synonym: "blood pressure regulation by renin-angiotensin" EXACT [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003082 +name: obsolete positive regulation of renal output by angiotensin +namespace: biological_process +def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] +comment: This term was made obsolete because the term is misleading. +synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of renal output by angiotensin" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003083 +name: negative regulation of renal output by angiotensin +namespace: biological_process +def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] +synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] +synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] +is_a: GO:0002019 ! regulation of renal output by angiotensin +is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure + +[Term] +id: GO:0003084 +name: positive regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] +is_a: GO:0045777 ! positive regulation of blood pressure +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003085 +name: negative regulation of systemic arterial blood pressure +namespace: biological_process +def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] +is_a: GO:0045776 ! negative regulation of blood pressure +relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure + +[Term] +id: GO:0003086 +name: regulation of systemic arterial blood pressure by local renal renin-angiotensin +namespace: biological_process +def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] +is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin + +[Term] +id: GO:0003087 +name: positive regulation of the force of heart contraction by neuronal epinephrine +namespace: biological_process +def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] +synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] +synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] +is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine +relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine + +[Term] +id: GO:0003088 +name: positive regulation of the force of heart contraction by circulating epinephrine +namespace: biological_process +def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] +synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] +synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] +synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] +is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine +relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine + +[Term] +id: GO:0003089 +name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] +synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] +is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003090 +name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine +namespace: biological_process +def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] +synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] +synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] +synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] +is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine + +[Term] +id: GO:0003091 +name: renal water homeostasis +namespace: biological_process +def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] +synonym: "water homeostasis by the renal system" EXACT [] +is_a: GO:0003014 ! renal system process +is_a: GO:0050891 ! multicellular organismal water homeostasis + +[Term] +id: GO:0003092 +name: renal water retention +namespace: biological_process +def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio] +synonym: "negative regulation of renal water excretion" EXACT [] +is_a: GO:0035811 ! negative regulation of urine volume + +[Term] +id: GO:0003093 +name: regulation of glomerular filtration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0001977 ! renal system process involved in regulation of blood volume +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003094 +name: glomerular filtration +namespace: biological_process +def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] +is_a: GO:0097205 ! renal filtration + +[Term] +id: GO:0003095 +name: pressure natriuresis +namespace: biological_process +def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio] +is_a: GO:0001977 ! renal system process involved in regulation of blood volume + +[Term] +id: GO:0003096 +name: renal sodium ion transport +namespace: biological_process +def: "The directed movement of sodium ions (Na+) by the renal system." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0006814 ! sodium ion transport + +[Term] +id: GO:0003097 +name: renal water transport +namespace: biological_process +def: "The directed movement of water (H2O) by the renal system." [GOC:mtg_cardio] +is_a: GO:0003014 ! renal system process +is_a: GO:0006833 ! water transport +relationship: part_of GO:0003091 ! renal water homeostasis + +[Term] +id: GO:0003098 +name: tubuloglomerular feedback +namespace: biological_process +def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] +xref: Wikipedia:Tubuloglomerular_feedback +is_a: GO:0001977 ! renal system process involved in regulation of blood volume +relationship: part_of GO:0003093 ! regulation of glomerular filtration + +[Term] +id: GO:0003099 +name: positive regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal +is_a: GO:0045823 ! positive regulation of heart contraction + +[Term] +id: GO:0003100 +name: regulation of systemic arterial blood pressure by endothelin +namespace: biological_process +def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003101 +name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine +namespace: biological_process +def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] +synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] +is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone + +[Term] +id: GO:0003102 +name: obsolete positive regulation of diuresis by angiotensin +namespace: biological_process +def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] +comment: This term was made obsolete because the term is misleading. +synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of diuresis by angiotensin" EXACT [] +is_obsolete: true +consider: GO:0035810 + +[Term] +id: GO:0003103 +name: obsolete positive regulation of diuresis +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "positive regulation of diuresis" EXACT [] +is_obsolete: true +consider: GO:0035810 + +[Term] +id: GO:0003104 +name: positive regulation of glomerular filtration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0003093 ! regulation of glomerular filtration +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003105 +name: negative regulation of glomerular filtration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] +is_a: GO:0003093 ! regulation of glomerular filtration +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0003094 ! glomerular filtration + +[Term] +id: GO:0003106 +name: negative regulation of glomerular filtration by angiotensin +namespace: biological_process +def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] +synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb] +synonym: "regulation of glomerular filtration by angiotensin" BROAD [] +is_a: GO:0003083 ! negative regulation of renal output by angiotensin +relationship: part_of GO:0003105 ! negative regulation of glomerular filtration + +[Term] +id: GO:0003107 +name: obsolete positive regulation of natriuresis by angiotensin +namespace: biological_process +def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] +comment: This term was made obsolete because the term is misleading. +synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of natriuresis by angiotensin" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003108 +name: negative regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] +synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] +is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal +is_a: GO:0045822 ! negative regulation of heart contraction + +[Term] +id: GO:0003109 +name: positive regulation of the force of heart contraction by circulating norepinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] +synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine + +[Term] +id: GO:0003110 +name: positive regulation of the force of heart contraction by neuronal norepinephrine +namespace: biological_process +def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] +synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] +synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine + +[Term] +id: GO:0003111 +name: positive regulation of heart rate by circulating epinephrine +namespace: biological_process +def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] +is_a: GO:0003065 ! positive regulation of heart rate by epinephrine + +[Term] +id: GO:0003112 +name: positive regulation of heart rate by neuronal epinephrine +namespace: biological_process +def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] +is_a: GO:0003065 ! positive regulation of heart rate by epinephrine + +[Term] +id: GO:0003113 +name: positive regulation of heart rate by neuronal norepinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] +is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine + +[Term] +id: GO:0003114 +name: positive regulation of heart rate by circulating norepinephrine +namespace: biological_process +def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] +synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] +is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine + +[Term] +id: GO:0003115 +name: regulation of vasoconstriction by epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +is_a: GO:0019229 ! regulation of vasoconstriction + +[Term] +id: GO:0003116 +name: regulation of vasoconstriction by norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +is_a: GO:0019229 ! regulation of vasoconstriction + +[Term] +id: GO:0003117 +name: regulation of vasoconstriction by circulating norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] +is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine + +[Term] +id: GO:0003118 +name: regulation of vasoconstriction by neuronal norepinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] +is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine + +[Term] +id: GO:0003119 +name: regulation of vasoconstriction by neuronal epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] +is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine + +[Term] +id: GO:0003120 +name: regulation of vasoconstriction by circulating epinephrine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] +synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] +is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine + +[Term] +id: GO:0003121 +name: epinephrine-mediated vasodilation +namespace: biological_process +alt_id: GO:0003123 +alt_id: GO:0003124 +def: "A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by adrenaline" RELATED [] +synonym: "regulation of vasodilation by circulating adrenaline" RELATED [] +synonym: "regulation of vasodilation by circulating epinephrine" RELATED [] +synonym: "regulation of vasodilation by epinephrine" RELATED [] +synonym: "regulation of vasodilation by neuronal adrenaline" RELATED [] +synonym: "regulation of vasodilation by neuronal epinephrine" RELATED [] +is_a: GO:0042311 ! vasodilation + +[Term] +id: GO:0003122 +name: norepinephrine-mediated vasodilation +namespace: biological_process +alt_id: GO:0003125 +alt_id: GO:0003126 +def: "A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] +synonym: "regulation of vasodilation by circulating noradrenaline" RELATED [] +synonym: "regulation of vasodilation by circulating norepinephrine" RELATED [] +synonym: "regulation of vasodilation by neuronal noradrenaline" RELATED [] +synonym: "regulation of vasodilation by neuronal norepinephrine" RELATED [] +synonym: "regulation of vasodilation by noradrenaline" RELATED [] +synonym: "regulation of vasodilation by norepinephrine" RELATED [] +is_a: GO:0042311 ! vasodilation + +[Term] +id: GO:0003127 +name: detection of nodal flow +namespace: biological_process +def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] +is_a: GO:0009726 ! detection of endogenous stimulus +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0003128 +name: heart field specification +namespace: biological_process +def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart] +is_a: GO:0010092 ! specification of animal organ identity +relationship: part_of GO:0060914 ! heart formation + +[Term] +id: GO:0003129 +name: heart induction +namespace: biological_process +def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] +is_a: GO:0001759 ! organ induction +is_a: GO:2000826 ! regulation of heart morphogenesis +relationship: positively_regulates GO:0003128 ! heart field specification + +[Term] +id: GO:0003130 +name: BMP signaling pathway involved in heart induction +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart] +synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction + +[Term] +id: GO:0003131 +name: mesodermal-endodermal cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] +synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0003132 +name: mesodermal-endodermal cell signaling involved in heart induction +namespace: biological_process +def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] +synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah] +is_a: GO:0003131 ! mesodermal-endodermal cell signaling +relationship: part_of GO:0003129 ! heart induction + +[Term] +id: GO:0003133 +name: endodermal-mesodermal cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] +synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0003134 +name: endodermal-mesodermal cell signaling involved in heart induction +namespace: biological_process +def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] +synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah] +is_a: GO:0003133 ! endodermal-mesodermal cell signaling +relationship: part_of GO:0003129 ! heart induction + +[Term] +id: GO:0003135 +name: fibroblast growth factor receptor signaling pathway involved in heart induction +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] +synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0003129 ! heart induction + +[Term] +id: GO:0003136 +name: negative regulation of heart induction by canonical Wnt signaling pathway +namespace: biological_process +def: "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] +synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph] +synonym: "negative regulation of heart induction by canonical Wnt receptor signaling pathway" EXACT [] +synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of heart induction by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +is_a: GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway +is_a: GO:1901320 ! negative regulation of heart induction + +[Term] +id: GO:0003137 +name: Notch signaling pathway involved in heart induction +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] +synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0003129 ! heart induction + +[Term] +id: GO:0003138 +name: primary heart field specification +namespace: biological_process +def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] +synonym: "FHS specification" EXACT [GOC:rl] +synonym: "first heart field specification" EXACT [GOC:rl] +is_a: GO:0003128 ! heart field specification + +[Term] +id: GO:0003139 +name: secondary heart field specification +namespace: biological_process +def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] +synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] +synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708] +synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840] +is_a: GO:0003128 ! heart field specification + +[Term] +id: GO:0003140 +name: determination of left/right asymmetry in lateral mesoderm +namespace: biological_process +def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0048368 ! lateral mesoderm development + +[Term] +id: GO:0003141 +name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] +comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. +synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] +synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +is_obsolete: true +replaced_by: GO:1900164 + +[Term] +id: GO:0003142 +name: cardiogenic plate morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] +synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0003143 +name: embryonic heart tube morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis +relationship: part_of GO:0035050 ! embryonic heart tube development +relationship: part_of GO:0048562 ! embryonic organ morphogenesis + +[Term] +id: GO:0003144 +name: embryonic heart tube formation +namespace: biological_process +def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis + +[Term] +id: GO:0003145 +name: embryonic heart tube formation via epithelial folding +namespace: biological_process +def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] +is_a: GO:0003144 ! embryonic heart tube formation + +[Term] +id: GO:0003146 +name: heart jogging +namespace: biological_process +def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] +synonym: "cardiac jogging" EXACT [GOC:mtg_heart] +is_a: GO:0003143 ! embryonic heart tube morphogenesis +relationship: part_of GO:0061371 ! determination of heart left/right asymmetry + +[Term] +id: GO:0003147 +name: neural crest cell migration involved in heart formation +namespace: biological_process +def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] +is_a: GO:0001755 ! neural crest cell migration +is_a: GO:0060974 ! cell migration involved in heart formation +relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development + +[Term] +id: GO:0003148 +name: outflow tract septum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] +is_a: GO:0060411 ! cardiac septum morphogenesis +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0003149 +name: membranous septum morphogenesis +namespace: biological_process +def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060412 ! ventricular septum morphogenesis + +[Term] +id: GO:0003150 +name: muscular septum morphogenesis +namespace: biological_process +def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] +is_a: GO:0060415 ! muscle tissue morphogenesis +relationship: part_of GO:0060412 ! ventricular septum morphogenesis + +[Term] +id: GO:0003151 +name: outflow tract morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0003152 +name: morphogenesis of an epithelial fold involved in embryonic heart tube formation +namespace: biological_process +def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding + +[Term] +id: GO:0003153 +name: closure of embryonic heart tube +namespace: biological_process +def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] +is_a: GO:0060606 ! tube closure +relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding + +[Term] +id: GO:0003154 +name: BMP signaling pathway involved in determination of left/right symmetry +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling] +synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] +synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0003155 +name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] +synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] +synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] +is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry +relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm + +[Term] +id: GO:0003156 +name: regulation of animal organ formation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0048645 ! animal organ formation + +[Term] +id: GO:0003157 +name: endocardium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003158 +name: endothelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] +is_a: GO:0060429 ! epithelium development + +[Term] +id: GO:0003159 +name: morphogenesis of an endothelium +namespace: biological_process +def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0003158 ! endothelium development + +[Term] +id: GO:0003160 +name: endocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003157 ! endocardium development + +[Term] +id: GO:0003161 +name: cardiac conduction system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] +synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] +synonym: "heart conduction system development" EXACT [GOC:mtg_heart] +is_a: GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0003162 +name: atrioventricular node development +namespace: biological_process +def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] +synonym: "AV node development" EXACT [GOC:mtg_heart] +is_a: GO:0048738 ! cardiac muscle tissue development +relationship: part_of GO:0003161 ! cardiac conduction system development + +[Term] +id: GO:0003163 +name: sinoatrial node development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] +synonym: "SA node development" EXACT [GOC:mtg_heart] +synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0003228 ! atrial cardiac muscle tissue development +relationship: part_of GO:0003161 ! cardiac conduction system development + +[Term] +id: GO:0003164 +name: His-Purkinje system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] +is_a: GO:0003229 ! ventricular cardiac muscle tissue development +relationship: part_of GO:0003161 ! cardiac conduction system development + +[Term] +id: GO:0003165 +name: Purkinje myocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +synonym: "cardiac Purkinje fiber development" EXACT [] +is_a: GO:0003229 ! ventricular cardiac muscle tissue development +relationship: part_of GO:0003164 ! His-Purkinje system development + +[Term] +id: GO:0003166 +name: bundle of His development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] +synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] +is_a: GO:0003229 ! ventricular cardiac muscle tissue development +relationship: part_of GO:0003164 ! His-Purkinje system development + +[Term] +id: GO:0003167 +name: atrioventricular bundle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] +synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] +is_a: GO:0060932 ! His-Purkinje system cell differentiation +relationship: part_of GO:0003166 ! bundle of His development + +[Term] +id: GO:0003168 +name: Purkinje myocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] +is_a: GO:0060932 ! His-Purkinje system cell differentiation +relationship: part_of GO:0003165 ! Purkinje myocyte development + +[Term] +id: GO:0003169 +name: coronary vein morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] +is_a: GO:0048845 ! venous blood vessel morphogenesis +is_a: GO:0060977 ! coronary vasculature morphogenesis + +[Term] +id: GO:0003170 +name: heart valve development +namespace: biological_process +def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] +synonym: "cardiac valve development" EXACT [GOC:mtg_heart] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003171 +name: atrioventricular valve development +namespace: biological_process +def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] +synonym: "AV valve development" EXACT [GOC:mah] +is_a: GO:0003170 ! heart valve development + +[Term] +id: GO:0003172 +name: sinoatrial valve development +namespace: biological_process +def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] +synonym: "SA valve development" EXACT [GOC:mah] +is_a: GO:0003170 ! heart valve development + +[Term] +id: GO:0003173 +name: ventriculo bulbo valve development +namespace: biological_process +def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003170 ! heart valve development + +[Term] +id: GO:0003174 +name: mitral valve development +namespace: biological_process +def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003171 ! atrioventricular valve development + +[Term] +id: GO:0003175 +name: tricuspid valve development +namespace: biological_process +def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003171 ! atrioventricular valve development + +[Term] +id: GO:0003176 +name: aortic valve development +namespace: biological_process +def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:1905314 ! semi-lunar valve development + +[Term] +id: GO:0003177 +name: pulmonary valve development +namespace: biological_process +def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:1905314 ! semi-lunar valve development + +[Term] +id: GO:0003178 +name: coronary sinus valve development +namespace: biological_process +def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003170 ! heart valve development + +[Term] +id: GO:0003179 +name: heart valve morphogenesis +namespace: biological_process +def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] +synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf] +synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003170 ! heart valve development + +[Term] +id: GO:0003180 +name: aortic valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003176 ! aortic valve development + +[Term] +id: GO:0003181 +name: atrioventricular valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart] +synonym: "AV valve morphogenesis" EXACT [GOC:mah] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003171 ! atrioventricular valve development + +[Term] +id: GO:0003182 +name: coronary sinus valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003178 ! coronary sinus valve development + +[Term] +id: GO:0003183 +name: mitral valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003181 ! atrioventricular valve morphogenesis +relationship: part_of GO:0003174 ! mitral valve development + +[Term] +id: GO:0003184 +name: pulmonary valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003177 ! pulmonary valve development + +[Term] +id: GO:0003185 +name: sinoatrial valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart] +synonym: "SA valve morphogenesis" EXACT [GOC:mah] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003172 ! sinoatrial valve development + +[Term] +id: GO:0003186 +name: tricuspid valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003181 ! atrioventricular valve morphogenesis +relationship: part_of GO:0003175 ! tricuspid valve development + +[Term] +id: GO:0003187 +name: ventriculo bulbo valve morphogenesis +namespace: biological_process +def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart] +is_a: GO:0003179 ! heart valve morphogenesis +relationship: part_of GO:0003173 ! ventriculo bulbo valve development + +[Term] +id: GO:0003188 +name: heart valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003179 ! heart valve morphogenesis + +[Term] +id: GO:0003189 +name: aortic valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003180 ! aortic valve morphogenesis + +[Term] +id: GO:0003190 +name: atrioventricular valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +synonym: "AV valve formation" EXACT [GOC:mah] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis + +[Term] +id: GO:0003191 +name: coronary sinus valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis + +[Term] +id: GO:0003192 +name: mitral valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003190 ! atrioventricular valve formation +relationship: part_of GO:0003183 ! mitral valve morphogenesis + +[Term] +id: GO:0003193 +name: pulmonary valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003184 ! pulmonary valve morphogenesis + +[Term] +id: GO:0003194 +name: sinoatrial valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +synonym: "SA valve formation" EXACT [GOC:mah] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis + +[Term] +id: GO:0003195 +name: tricuspid valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003190 ! atrioventricular valve formation +relationship: part_of GO:0003186 ! tricuspid valve morphogenesis + +[Term] +id: GO:0003196 +name: ventriculo bulbo valve formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] +is_a: GO:0003188 ! heart valve formation +relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis + +[Term] +id: GO:0003197 +name: endocardial cushion development +namespace: biological_process +def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003198 +name: epithelial to mesenchymal transition involved in endocardial cushion formation +namespace: biological_process +def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] +is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition +relationship: part_of GO:0003272 ! endocardial cushion formation + +[Term] +id: GO:0003199 +name: endocardial cushion to mesenchymal transition involved in heart valve formation +namespace: biological_process +def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] +synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf] +is_a: GO:0090500 ! endocardial cushion to mesenchymal transition +relationship: part_of GO:0003188 ! heart valve formation + +[Term] +id: GO:0003200 +name: endocardial cushion to mesenchymal transition involved in heart chamber septation +namespace: biological_process +def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] +is_a: GO:0090500 ! endocardial cushion to mesenchymal transition +relationship: part_of GO:0060411 ! cardiac septum morphogenesis + +[Term] +id: GO:0003201 +name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis +namespace: biological_process +def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] +is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition +relationship: part_of GO:0060977 ! coronary vasculature morphogenesis + +[Term] +id: GO:0003202 +name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development +namespace: biological_process +def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] +is_a: GO:0090500 ! endocardial cushion to mesenchymal transition +relationship: part_of GO:0003204 ! cardiac skeleton development + +[Term] +id: GO:0003203 +name: endocardial cushion morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] +is_a: GO:0072132 ! mesenchyme morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis +relationship: part_of GO:0003197 ! endocardial cushion development + +[Term] +id: GO:0003204 +name: cardiac skeleton development +namespace: biological_process +def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] +synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003205 +name: cardiac chamber development +namespace: biological_process +def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0003206 +name: cardiac chamber morphogenesis +namespace: biological_process +def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] +synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis +relationship: part_of GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003207 +name: cardiac chamber formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] +synonym: "heart chamber formation" EXACT [GOC:mtg_heart] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003206 ! cardiac chamber morphogenesis + +[Term] +id: GO:0003208 +name: cardiac ventricle morphogenesis +namespace: biological_process +def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003231 ! cardiac ventricle development + +[Term] +id: GO:0003209 +name: cardiac atrium morphogenesis +namespace: biological_process +def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003230 ! cardiac atrium development + +[Term] +id: GO:0003210 +name: cardiac atrium formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +relationship: part_of GO:0003209 ! cardiac atrium morphogenesis + +[Term] +id: GO:0003211 +name: cardiac ventricle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis + +[Term] +id: GO:0003212 +name: cardiac left atrium morphogenesis +namespace: biological_process +def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] +is_a: GO:0003209 ! cardiac atrium morphogenesis + +[Term] +id: GO:0003213 +name: cardiac right atrium morphogenesis +namespace: biological_process +def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] +is_a: GO:0003209 ! cardiac atrium morphogenesis + +[Term] +id: GO:0003214 +name: cardiac left ventricle morphogenesis +namespace: biological_process +def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] +is_a: GO:0003208 ! cardiac ventricle morphogenesis + +[Term] +id: GO:0003215 +name: cardiac right ventricle morphogenesis +namespace: biological_process +def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] +is_a: GO:0003208 ! cardiac ventricle morphogenesis + +[Term] +id: GO:0003216 +name: cardiac left atrium formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] +is_a: GO:0003210 ! cardiac atrium formation +relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis + +[Term] +id: GO:0003217 +name: cardiac right atrium formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] +is_a: GO:0003210 ! cardiac atrium formation +relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis + +[Term] +id: GO:0003218 +name: cardiac left ventricle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] +is_a: GO:0003211 ! cardiac ventricle formation +relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis + +[Term] +id: GO:0003219 +name: cardiac right ventricle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] +is_a: GO:0003211 ! cardiac ventricle formation +relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis + +[Term] +id: GO:0003220 +name: left ventricular cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis +relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis + +[Term] +id: GO:0003221 +name: right ventricular cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis +relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis + +[Term] +id: GO:0003222 +name: ventricular trabecula myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis +is_a: GO:0061384 ! heart trabecula morphogenesis + +[Term] +id: GO:0003223 +name: ventricular compact myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] +is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis + +[Term] +id: GO:0003224 +name: left ventricular compact myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003223 ! ventricular compact myocardium morphogenesis + +[Term] +id: GO:0003225 +name: left ventricular trabecular myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis + +[Term] +id: GO:0003226 +name: right ventricular compact myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003223 ! ventricular compact myocardium morphogenesis + +[Term] +id: GO:0003227 +name: right ventricular trabecular myocardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] +is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis +is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis + +[Term] +id: GO:0003228 +name: atrial cardiac muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] +synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] +is_a: GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0003229 +name: ventricular cardiac muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] +synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] +is_a: GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0003230 +name: cardiac atrium development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003231 +name: cardiac ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003232 +name: bulbus arteriosus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003233 +name: bulbus arteriosus morphogenesis +namespace: biological_process +def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003232 ! bulbus arteriosus development + +[Term] +id: GO:0003234 +name: bulbus arteriosus formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis + +[Term] +id: GO:0003235 +name: sinus venosus development +namespace: biological_process +def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003236 +name: sinus venosus morphogenesis +namespace: biological_process +def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003235 ! sinus venosus development + +[Term] +id: GO:0003237 +name: sinus venosus formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +relationship: part_of GO:0003236 ! sinus venosus morphogenesis + +[Term] +id: GO:0003238 +name: conus arteriosus development +namespace: biological_process +def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003239 +name: conus arteriosus morphogenesis +namespace: biological_process +def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003238 ! conus arteriosus development + +[Term] +id: GO:0003240 +name: conus arteriosus formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] +is_a: GO:0003207 ! cardiac chamber formation +relationship: part_of GO:0003239 ! conus arteriosus morphogenesis + +[Term] +id: GO:0003241 +name: growth involved in heart morphogenesis +namespace: biological_process +def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis +relationship: part_of GO:0060419 ! heart growth + +[Term] +id: GO:0003242 +name: cardiac chamber ballooning +namespace: biological_process +def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] +is_a: GO:0003241 ! growth involved in heart morphogenesis +relationship: part_of GO:0003206 ! cardiac chamber morphogenesis + +[Term] +id: GO:0003243 +name: circumferential growth involved in left ventricle morphogenesis +namespace: biological_process +def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] +is_a: GO:0003241 ! growth involved in heart morphogenesis +relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis + +[Term] +id: GO:0003244 +name: radial growth involved in right ventricle morphogenesis +namespace: biological_process +def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] +is_a: GO:0003241 ! growth involved in heart morphogenesis +relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis + +[Term] +id: GO:0003245 +name: cardiac muscle tissue growth involved in heart morphogenesis +namespace: biological_process +def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] +is_a: GO:0003241 ! growth involved in heart morphogenesis +is_a: GO:0055017 ! cardiac muscle tissue growth +relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis + +[Term] +id: GO:0003246 +name: embryonic cardiac muscle cell growth involved in heart morphogenesis +namespace: biological_process +def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] +synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] +is_a: GO:0003241 ! growth involved in heart morphogenesis +is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development +relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis + +[Term] +id: GO:0003247 +name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis +namespace: biological_process +def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] +is_a: GO:0003241 ! growth involved in heart morphogenesis +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis + +[Term] +id: GO:0003248 +name: heart capillary growth +namespace: biological_process +def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0060419 ! heart growth +relationship: part_of GO:0060976 ! coronary vasculature development + +[Term] +id: GO:0003249 +name: cell proliferation involved in heart valve morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis +is_a: GO:2000793 ! cell proliferation involved in heart valve development +relationship: part_of GO:0003179 ! heart valve morphogenesis + +[Term] +id: GO:0003250 +name: regulation of cell proliferation involved in heart valve morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] +is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis +relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis + +[Term] +id: GO:0003251 +name: positive regulation of cell proliferation involved in heart valve morphogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] +is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis +is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis +relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis + +[Term] +id: GO:0003252 +name: negative regulation of cell proliferation involved in heart valve morphogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] +is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis +is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis +relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis + +[Term] +id: GO:0003253 +name: cardiac neural crest cell migration involved in outflow tract morphogenesis +namespace: biological_process +def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] +is_a: GO:0001755 ! neural crest cell migration +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis + +[Term] +id: GO:0003254 +name: regulation of membrane depolarization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] +is_a: GO:0042391 ! regulation of membrane potential +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0050801 ! ion homeostasis +relationship: regulates GO:0051899 ! membrane depolarization + +[Term] +id: GO:0003255 +name: endocardial precursor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] +is_a: GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0003256 +name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] +is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development +relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation + +[Term] +id: GO:0003257 +name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] +is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation +is_a: GO:1901228 ! positive regulation of transcription from RNA polymerase II promoter involved in heart development + +[Term] +id: GO:0003258 +name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] +is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development +relationship: part_of GO:0003255 ! endocardial precursor cell differentiation + +[Term] +id: GO:0003259 +name: cardioblast anterior-lateral migration +namespace: biological_process +def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +is_a: GO:0003260 ! cardioblast migration + +[Term] +id: GO:0003260 +name: cardioblast migration +namespace: biological_process +def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +is_a: GO:0060974 ! cell migration involved in heart formation + +[Term] +id: GO:0003261 +name: cardiac muscle progenitor cell migration to the midline involved in heart field formation +namespace: biological_process +def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] +synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] +is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation + +[Term] +id: GO:0003262 +name: endocardial progenitor cell migration to the midline involved in heart field formation +namespace: biological_process +def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] +is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation + +[Term] +id: GO:0003263 +name: cardioblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis +relationship: part_of GO:0060914 ! heart formation + +[Term] +id: GO:0003264 +name: regulation of cardioblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis +relationship: regulates GO:0003263 ! cardioblast proliferation + +[Term] +id: GO:0003265 +name: regulation of primary heart field cardioblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] +synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl] +synonym: "regulation of first heart field cardiac proliferation" RELATED [] +synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl] +is_a: GO:0003264 ! regulation of cardioblast proliferation + +[Term] +id: GO:0003266 +name: regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] +synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] +synonym: "regulation of SHF cardioblast proliferation" EXACT [GOC:rl] +is_a: GO:0003264 ! regulation of cardioblast proliferation + +[Term] +id: GO:0003267 +name: canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" RELATED [GOC:signaling] +is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation + +[Term] +id: GO:0003268 +name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph] +synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf] +synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah] +is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development +relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation + +[Term] +id: GO:0003269 +name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] +synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] +is_a: GO:0061312 ! BMP signaling pathway involved in heart development +relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation + +[Term] +id: GO:0003270 +name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph] +synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] +is_a: GO:0061314 ! Notch signaling involved in heart development +relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation + +[Term] +id: GO:0003271 +name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] +synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf] +synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] +is_a: GO:0007224 ! smoothened signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development +relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation + +[Term] +id: GO:0003272 +name: endocardial cushion formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:0003273 +name: cell migration involved in endocardial cushion formation +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0003272 ! endocardial cushion formation + +[Term] +id: GO:0003274 +name: endocardial cushion fusion +namespace: biological_process +def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] +is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:0003275 +name: apoptotic process involved in outflow tract morphogenesis +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] +synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] +is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0003276 +name: apoptotic process involved in heart valve morphogenesis +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart] +synonym: "apoptosis involved in heart valve morphogenesis" NARROW [] +is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis +relationship: part_of GO:0003179 ! heart valve morphogenesis + +[Term] +id: GO:0003277 +name: apoptotic process involved in endocardial cushion morphogenesis +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] +synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] +is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis +relationship: part_of GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:0003278 +name: apoptotic process involved in heart morphogenesis +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] +synonym: "apoptosis involved in heart morphogenesis" NARROW [] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0003279 +name: cardiac septum development +namespace: biological_process +def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] +synonym: "heart septum development" EXACT [GOC:mtg_heart] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0003205 ! cardiac chamber development + +[Term] +id: GO:0003281 +name: ventricular septum development +namespace: biological_process +def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] +synonym: "interventricular septum development" EXACT [GOC:mtg_heart] +synonym: "septum inferius development" NARROW [GOC:mtg_heart] +is_a: GO:0003279 ! cardiac septum development +relationship: part_of GO:0003231 ! cardiac ventricle development + +[Term] +id: GO:0003282 +name: ventricular septum intermedium development +namespace: biological_process +def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003281 ! ventricular septum development + +[Term] +id: GO:0003283 +name: atrial septum development +namespace: biological_process +def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003279 ! cardiac septum development +relationship: part_of GO:0003230 ! cardiac atrium development + +[Term] +id: GO:0003284 +name: septum primum development +namespace: biological_process +def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003283 ! atrial septum development + +[Term] +id: GO:0003285 +name: septum secundum development +namespace: biological_process +def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003283 ! atrial septum development + +[Term] +id: GO:0003286 +name: atrial septum intermedium development +namespace: biological_process +def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] +is_a: GO:0003283 ! atrial septum development + +[Term] +id: GO:0003288 +name: ventricular septum intermedium morphogenesis +namespace: biological_process +def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] +is_a: GO:0060412 ! ventricular septum morphogenesis + +[Term] +id: GO:0003289 +name: atrial septum primum morphogenesis +namespace: biological_process +def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] +is_a: GO:0060413 ! atrial septum morphogenesis +relationship: part_of GO:0003284 ! septum primum development + +[Term] +id: GO:0003290 +name: atrial septum secundum morphogenesis +namespace: biological_process +def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] +is_a: GO:0060413 ! atrial septum morphogenesis +relationship: part_of GO:0003285 ! septum secundum development + +[Term] +id: GO:0003291 +name: atrial septum intermedium morphogenesis +namespace: biological_process +def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] +is_a: GO:0060413 ! atrial septum morphogenesis +relationship: part_of GO:0003286 ! atrial septum intermedium development + +[Term] +id: GO:0003292 +name: cardiac septum cell differentiation +namespace: biological_process +def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] +is_a: GO:0035051 ! cardiocyte differentiation +relationship: part_of GO:0003279 ! cardiac septum development + +[Term] +id: GO:0003293 +name: heart valve cell differentiation +namespace: biological_process +def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] +is_a: GO:0035051 ! cardiocyte differentiation +relationship: part_of GO:0003170 ! heart valve development + +[Term] +id: GO:0003294 +name: atrial ventricular junction remodeling +namespace: biological_process +def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart] +synonym: "atrio-ventricular junction remodeling" RELATED [GOC:mtg_heart] +synonym: "atrioventricular junction remodeling" EXACT [GOC:mtg_heart] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0003295 +name: cell proliferation involved in atrial ventricular junction remodeling +namespace: biological_process +def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] +synonym: "cell proliferation involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] +synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis +relationship: part_of GO:0003294 ! atrial ventricular junction remodeling + +[Term] +id: GO:0003296 +name: apoptotic process involved in atrial ventricular junction remodeling +namespace: biological_process +def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart] +synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW [] +synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] +synonym: "apoptosis involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] +is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis +relationship: part_of GO:0003294 ! atrial ventricular junction remodeling + +[Term] +id: GO:0003297 +name: heart wedging +namespace: biological_process +def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0003298 +name: physiological muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] +is_a: GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0003299 +name: muscle hypertrophy in response to stress +namespace: biological_process +def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] +is_a: GO:0006950 ! response to stress +is_a: GO:0014896 ! muscle hypertrophy +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0003300 +name: cardiac muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] +is_a: GO:0014897 ! striated muscle hypertrophy + +[Term] +id: GO:0003301 +name: physiological cardiac muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +is_a: GO:0003298 ! physiological muscle hypertrophy +is_a: GO:0003300 ! cardiac muscle hypertrophy +relationship: part_of GO:0055017 ! cardiac muscle tissue growth + +[Term] +id: GO:0003302 +name: transforming growth factor beta receptor signaling pathway involved in heart jogging +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling] +synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] +is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry +is_a: GO:1905313 ! transforming growth factor beta receptor signaling pathway involved in heart development +relationship: part_of GO:0003146 ! heart jogging + +[Term] +id: GO:0003303 +name: BMP signaling pathway involved in heart jogging +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart] +synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah] +is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry +is_a: GO:0061312 ! BMP signaling pathway involved in heart development +relationship: part_of GO:0003146 ! heart jogging + +[Term] +id: GO:0003304 +name: myocardial epithelial involution involved in heart jogging +namespace: biological_process +def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0003146 ! heart jogging + +[Term] +id: GO:0003305 +name: cell migration involved in heart jogging +namespace: biological_process +def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0003146 ! heart jogging + +[Term] +id: GO:0003306 +name: Wnt signaling pathway involved in heart development +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] +synonym: "Wnt receptor signaling pathway involved in heart development" EXACT [] +synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development + +[Term] +id: GO:0003307 +name: regulation of Wnt signaling pathway involved in heart development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] +synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] +synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development + +[Term] +id: GO:0003308 +name: negative regulation of Wnt signaling pathway involved in heart development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] +synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] +synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] +is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development + +[Term] +id: GO:0003309 +name: type B pancreatic cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] +synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] +synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +relationship: part_of GO:0031018 ! endocrine pancreas development + +[Term] +id: GO:0003310 +name: pancreatic A cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] +synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +relationship: part_of GO:0031018 ! endocrine pancreas development + +[Term] +id: GO:0003311 +name: pancreatic D cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] +synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +relationship: part_of GO:0031018 ! endocrine pancreas development + +[Term] +id: GO:0003312 +name: pancreatic PP cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] +synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] +is_a: GO:0035883 ! enteroendocrine cell differentiation +relationship: part_of GO:0031018 ! endocrine pancreas development + +[Term] +id: GO:0003313 +name: heart rudiment development +namespace: biological_process +def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] +synonym: "heart cone development" EXACT [GOC:mtg_heart] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0035050 ! embryonic heart tube development + +[Term] +id: GO:0003314 +name: heart rudiment morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] +synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0003313 ! heart rudiment development + +[Term] +id: GO:0003315 +name: heart rudiment formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] +synonym: "heart cone formation" EXACT [GOC:mtg_heart] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003314 ! heart rudiment morphogenesis + +[Term] +id: GO:0003316 +name: establishment of myocardial progenitor cell apical/basal polarity +namespace: biological_process +def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] +synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] +is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity +relationship: part_of GO:0003315 ! heart rudiment formation + +[Term] +id: GO:0003317 +name: cardioblast cell midline fusion +namespace: biological_process +def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] +synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] +is_a: GO:0034109 ! homotypic cell-cell adhesion +relationship: part_of GO:0003315 ! heart rudiment formation + +[Term] +id: GO:0003318 +name: cell migration to the midline involved in heart development +namespace: biological_process +def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] +is_a: GO:0060973 ! cell migration involved in heart development + +[Term] +id: GO:0003319 +name: cardioblast migration to the midline involved in heart rudiment formation +namespace: biological_process +def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] +is_a: GO:0003318 ! cell migration to the midline involved in heart development +relationship: part_of GO:0003315 ! heart rudiment formation + +[Term] +id: GO:0003320 +name: heart rudiment involution +namespace: biological_process +def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] +is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation + +[Term] +id: GO:0003321 +name: positive regulation of blood pressure by epinephrine-norepinephrine +namespace: biological_process +def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] +is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine +is_a: GO:0045777 ! positive regulation of blood pressure + +[Term] +id: GO:0003322 +name: pancreatic A cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] +synonym: "pancreatic alpha cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +relationship: part_of GO:0003310 ! pancreatic A cell differentiation + +[Term] +id: GO:0003323 +name: type B pancreatic cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] +synonym: "pancreatic B cell development" EXACT [GOC:mah] +synonym: "pancreatic beta cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +relationship: part_of GO:0003309 ! type B pancreatic cell differentiation + +[Term] +id: GO:0003324 +name: pancreatic D cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] +synonym: "pancreatic delta cell development" EXACT [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +relationship: part_of GO:0003311 ! pancreatic D cell differentiation + +[Term] +id: GO:0003325 +name: pancreatic PP cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] +is_a: GO:0002068 ! glandular epithelial cell development +relationship: part_of GO:0003312 ! pancreatic PP cell differentiation + +[Term] +id: GO:0003326 +name: pancreatic A cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0003310 ! pancreatic A cell differentiation + +[Term] +id: GO:0003327 +name: type B pancreatic cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] +synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0003309 ! type B pancreatic cell differentiation + +[Term] +id: GO:0003328 +name: pancreatic D cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0003311 ! pancreatic D cell differentiation + +[Term] +id: GO:0003329 +name: pancreatic PP cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0003312 ! pancreatic PP cell differentiation + +[Term] +id: GO:0003330 +name: regulation of extracellular matrix constituent secretion +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] +is_a: GO:1903053 ! regulation of extracellular matrix organization +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0070278 ! extracellular matrix constituent secretion + +[Term] +id: GO:0003331 +name: positive regulation of extracellular matrix constituent secretion +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] +is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion +is_a: GO:1903055 ! positive regulation of extracellular matrix organization +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion + +[Term] +id: GO:0003332 +name: negative regulation of extracellular matrix constituent secretion +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] +is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion +is_a: GO:1903054 ! negative regulation of extracellular matrix organization +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion + +[Term] +id: GO:0003333 +name: amino acid transmembrane transport +namespace: biological_process +def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "amino acid membrane transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0003334 +name: keratinocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0003335 +name: corneocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0003334 ! keratinocyte development + +[Term] +id: GO:0003336 +name: corneocyte desquamation +namespace: biological_process +def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph] +synonym: "epidermal desquamation" EXACT [GOC:dph] +is_a: GO:0060232 ! delamination +relationship: part_of GO:0003335 ! corneocyte development + +[Term] +id: GO:0003337 +name: mesenchymal to epithelial transition involved in metanephros morphogenesis +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] +synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +is_a: GO:0060231 ! mesenchymal to epithelial transition +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis + +[Term] +id: GO:0003338 +name: metanephros morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf] +is_a: GO:0060993 ! kidney morphogenesis +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0003339 +name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] +is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development +relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis + +[Term] +id: GO:0003340 +name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] +is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis +is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development +relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis + +[Term] +id: GO:0003341 +name: cilium movement +namespace: biological_process +alt_id: GO:0036142 +def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "ciliary motility" RELATED [] +synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "flagellar motility" RELATED [] +synonym: "flagellar movement" NARROW [GOC:bf] +synonym: "flagellum movement" NARROW [] +synonym: "microtubule-based flagellum movement" EXACT [] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0003342 +name: proepicardium development +namespace: biological_process +def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0003343 ! septum transversum development + +[Term] +id: GO:0003343 +name: septum transversum development +namespace: biological_process +def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] +is_a: GO:0060485 ! mesenchyme development + +[Term] +id: GO:0003344 +name: pericardium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060039 ! pericardium development + +[Term] +id: GO:0003345 +name: proepicardium cell migration involved in pericardium morphogenesis +namespace: biological_process +def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0003344 ! pericardium morphogenesis + +[Term] +id: GO:0003346 +name: epicardium-derived cell migration to the myocardium +namespace: biological_process +def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] +is_a: GO:0060973 ! cell migration involved in heart development + +[Term] +id: GO:0003347 +name: epicardial cell to mesenchymal cell transition +namespace: biological_process +def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] +is_a: GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0003348 +name: cardiac endothelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] +is_a: GO:0035051 ! cardiocyte differentiation +is_a: GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0003349 +name: epicardium-derived cardiac endothelial cell differentiation +namespace: biological_process +def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] +is_a: GO:0003348 ! cardiac endothelial cell differentiation + +[Term] +id: GO:0003350 +name: pulmonary myocardium development +namespace: biological_process +def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] +is_a: GO:0014706 ! striated muscle tissue development +relationship: part_of GO:0060841 ! venous blood vessel development + +[Term] +id: GO:0003351 +name: epithelial cilium movement involved in extracellular fluid movement +namespace: biological_process +def: "The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid." [GOC:dph, GOC:krc] +synonym: "cilium movement involved in fluid flow" RELATED [GOC:cilia] +synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003341 ! cilium movement +is_a: GO:0006858 ! extracellular transport +is_a: GO:0099111 ! microtubule-based transport + +[Term] +id: GO:0003352 +name: regulation of cilium movement +namespace: biological_process +alt_id: GO:1900172 +def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] +synonym: "regulation of flagellum movement" RELATED [] +synonym: "regulation of microtubule-based flagellum movement" EXACT [] +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0003341 ! cilium movement + +[Term] +id: GO:0003353 +name: positive regulation of cilium movement +namespace: biological_process +alt_id: GO:1900174 +def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] +synonym: "positive regulation of flagellum movement" RELATED [] +synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] +is_a: GO:0003352 ! regulation of cilium movement +is_a: GO:0051272 ! positive regulation of cellular component movement +relationship: positively_regulates GO:0003341 ! cilium movement + +[Term] +id: GO:0003354 +name: negative regulation of cilium movement +namespace: biological_process +alt_id: GO:1900173 +def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "negative regulation of flagellum movement" RELATED [] +synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] +is_a: GO:0003352 ! regulation of cilium movement +is_a: GO:0051271 ! negative regulation of cellular component movement +relationship: negatively_regulates GO:0003341 ! cilium movement + +[Term] +id: GO:0003355 +name: cilium movement involved in otolith formation +namespace: biological_process +def: "The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles." [GOC:dph, GOC:krc, PMID:19043402] +is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement +relationship: part_of GO:0032475 ! otolith formation + +[Term] +id: GO:0003356 +name: regulation of cilium beat frequency +namespace: biological_process +alt_id: GO:0036144 +def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "regulation of flagellum beat frequency" RELATED [] +synonym: "regulation of microtubule-based flagellum beat frequency" EXACT [] +is_a: GO:0003352 ! regulation of cilium movement + +[Term] +id: GO:0003357 +name: noradrenergic neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] +synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0003358 +name: noradrenergic neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] +synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0003357 ! noradrenergic neuron differentiation + +[Term] +id: GO:0003359 +name: noradrenergic neuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] +synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0003357 ! noradrenergic neuron differentiation + +[Term] +id: GO:0003360 +name: brainstem development +namespace: biological_process +def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0003361 +name: noradrenergic neuron differentiation involved in brainstem development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] +is_a: GO:0003357 ! noradrenergic neuron differentiation +relationship: part_of GO:0003360 ! brainstem development + +[Term] +id: GO:0003362 +name: noradrenergic neuron fate commitment involved in brainstem development +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] +is_a: GO:0003359 ! noradrenergic neuron fate commitment +relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development + +[Term] +id: GO:0003363 +name: lamellipodium assembly involved in ameboidal cell migration +namespace: biological_process +def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030032 ! lamellipodium assembly +relationship: part_of GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0003364 +name: lamellipodium assembly involved in mesendodermal cell migration +namespace: biological_process +def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration + +[Term] +id: GO:0003365 +name: establishment of cell polarity involved in ameboidal cell migration +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030010 ! establishment of cell polarity +relationship: part_of GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0003366 +name: cell-matrix adhesion involved in ameboidal cell migration +namespace: biological_process +def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007160 ! cell-matrix adhesion +relationship: part_of GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0003367 +name: cell-cell adhesion involved in ameboidal cell migration +namespace: biological_process +def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration + +[Term] +id: GO:0003368 +name: cell-matrix adhesion involved in mesendodermal cell migration +namespace: biological_process +def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration +relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration + +[Term] +id: GO:0003369 +name: establishment of cell polarity involved in mesendodermal cell migration +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration +relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration + +[Term] +id: GO:0003370 +name: cell-cell adhesion involved in mesendodermal cell migration +namespace: biological_process +def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration +is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation +relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration + +[Term] +id: GO:0003371 +name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity +relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration + +[Term] +id: GO:0003372 +name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation +relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration + +[Term] +id: GO:0003373 +name: dynamin family protein polymerization involved in membrane fission +namespace: biological_process +def: "The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0051258 ! protein polymerization +relationship: part_of GO:0090148 ! membrane fission + +[Term] +id: GO:0003374 +name: dynamin family protein polymerization involved in mitochondrial fission +namespace: biological_process +def: "The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003373 ! dynamin family protein polymerization involved in membrane fission + +[Term] +id: GO:0003375 +name: regulation of dynamin family protein polymerization involved in membrane fission +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032271 ! regulation of protein polymerization +relationship: regulates GO:0003373 ! dynamin family protein polymerization involved in membrane fission + +[Term] +id: GO:0003376 +name: sphingosine-1-phosphate receptor signaling pathway +namespace: biological_process +alt_id: GO:0001789 +def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428] +synonym: "S1P receptor signaling pathway" EXACT [GOC:bf] +synonym: "S1P signaling pathway" RELATED [GOC:bf] +synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] +synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf] +synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186] +synonym: "sphingolipid signaling pathway" BROAD [GOC:bf] +synonym: "sphingolipid signalling pathway" BROAD [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0090520 ! sphingolipid mediated signaling pathway + +[Term] +id: GO:0003377 +name: obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway +namespace: biological_process +def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf] +synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0003378 +name: obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway +namespace: biological_process +def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf] +synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0003379 +name: establishment of cell polarity involved in gastrulation cell migration +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration +relationship: part_of GO:0042074 ! cell migration involved in gastrulation + +[Term] +id: GO:0003380 +name: establishment or maintenance of cytoskeleton polarity involved in gastrulation +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration +relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration + +[Term] +id: GO:0003381 +name: epithelial cell morphogenesis involved in gastrulation +namespace: biological_process +def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003382 ! epithelial cell morphogenesis +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0003382 +name: epithelial cell morphogenesis +namespace: biological_process +def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0002064 ! epithelial cell development + +[Term] +id: GO:0003383 +name: apical constriction +namespace: biological_process +def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0070252 ! actin-mediated cell contraction +relationship: part_of GO:0003382 ! epithelial cell morphogenesis + +[Term] +id: GO:0003384 +name: apical constriction involved in gastrulation +namespace: biological_process +def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003383 ! apical constriction +relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation + +[Term] +id: GO:0003385 +name: cell-cell signaling involved in amphid sensory organ development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0003386 ! amphid sensory organ development + +[Term] +id: GO:0003386 +name: amphid sensory organ development +namespace: biological_process +def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0003387 +name: neuron differentiation involved in amphid sensory organ development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0003386 ! amphid sensory organ development + +[Term] +id: GO:0003388 +name: neuron development involved in amphid sensory organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development + +[Term] +id: GO:0003389 +name: retrograde extension +namespace: biological_process +def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0031175 ! neuron projection development + +[Term] +id: GO:0003390 +name: dendrite development by retrograde extension +namespace: biological_process +def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003389 ! retrograde extension +is_a: GO:0016358 ! dendrite development + +[Term] +id: GO:0003391 +name: amphid sensory organ dendrite retrograde extension +namespace: biological_process +def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003390 ! dendrite development by retrograde extension +relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development + +[Term] +id: GO:0003392 +name: cell adhesion involved in retrograde extension +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007155 ! cell adhesion +relationship: part_of GO:0003389 ! retrograde extension + +[Term] +id: GO:0003393 +name: neuron migration involved in retrograde extension +namespace: biological_process +def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0001764 ! neuron migration +relationship: part_of GO:0003389 ! retrograde extension + +[Term] +id: GO:0003394 +name: cell adhesion involved in dendrite retrograde extension +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003392 ! cell adhesion involved in retrograde extension +relationship: part_of GO:0003390 ! dendrite development by retrograde extension + +[Term] +id: GO:0003395 +name: neuron migration involved in dendrite retrograde extension +namespace: biological_process +def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003393 ! neuron migration involved in retrograde extension +relationship: part_of GO:0003390 ! dendrite development by retrograde extension + +[Term] +id: GO:0003396 +name: cell adhesion involved in amphid sensory organ dendrite retrograde extension +namespace: biological_process +def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension +relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension + +[Term] +id: GO:0003397 +name: neuron migration involved in amphid sensory organ dendrite retrograde extension +namespace: biological_process +def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension +relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension + +[Term] +id: GO:0003398 +name: glial cell differentiation involved in amphid sensory organ development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0003386 ! amphid sensory organ development + +[Term] +id: GO:0003399 +name: cytoneme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis + +[Term] +id: GO:0003400 +name: regulation of COPII vesicle coating +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis +relationship: regulates GO:0048208 ! COPII vesicle coating + +[Term] +id: GO:0003401 +name: axis elongation +namespace: biological_process +def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060560 ! developmental growth involved in morphogenesis + +[Term] +id: GO:0003402 +name: planar cell polarity pathway involved in axis elongation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +relationship: part_of GO:0003401 ! axis elongation + +[Term] +id: GO:0003403 +name: optic vesicle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003404 ! optic vesicle morphogenesis +relationship: part_of GO:0060900 ! embryonic camera-type eye formation + +[Term] +id: GO:0003404 +name: optic vesicle morphogenesis +namespace: biological_process +def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis + +[Term] +id: GO:0003405 +name: optic vesicle elongation +namespace: biological_process +def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0003404 ! optic vesicle morphogenesis + +[Term] +id: GO:0003406 +name: retinal pigment epithelium development +namespace: biological_process +def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:0003407 +name: neural retina development +namespace: biological_process +def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:0003408 +name: optic cup formation involved in camera-type eye development +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development + +[Term] +id: GO:0003409 +name: optic cup structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "optic cup structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development + +[Term] +id: GO:0003410 +name: anterior rotation of the optic cup +namespace: biological_process +def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0003411 +name: cell motility involved in camera-type eye morphogenesis +namespace: biological_process +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048870 ! cell motility +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0003412 +name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis +namespace: biological_process +def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0003413 +name: chondrocyte differentiation involved in endochondral bone morphogenesis +namespace: biological_process +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0002062 ! chondrocyte differentiation +relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis + +[Term] +id: GO:0003414 +name: chondrocyte morphogenesis involved in endochondral bone morphogenesis +namespace: biological_process +def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090171 ! chondrocyte morphogenesis +relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis + +[Term] +id: GO:0003415 +name: chondrocyte hypertrophy +namespace: biological_process +def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0002063 ! chondrocyte development + +[Term] +id: GO:0003416 +name: endochondral bone growth +namespace: biological_process +def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0098868 ! bone growth + +[Term] +id: GO:0003417 +name: growth plate cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0003416 ! endochondral bone growth + +[Term] +id: GO:0003418 +name: growth plate cartilage chondrocyte differentiation +namespace: biological_process +def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis +relationship: part_of GO:0003417 ! growth plate cartilage development + +[Term] +id: GO:0003419 +name: growth plate cartilage chondrocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0003417 ! growth plate cartilage development + +[Term] +id: GO:0003420 +name: regulation of growth plate cartilage chondrocyte proliferation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation + +[Term] +id: GO:0003421 +name: growth plate cartilage axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis + +[Term] +id: GO:0003422 +name: growth plate cartilage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060536 ! cartilage morphogenesis +relationship: part_of GO:0003417 ! growth plate cartilage development + +[Term] +id: GO:0003423 +name: growth plate cartilage chondrocyte division +namespace: biological_process +def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation + +[Term] +id: GO:0003424 +name: establishment of cell polarity involved in growth plate cartilage chondrocyte division +namespace: biological_process +def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0030010 ! establishment of cell polarity +relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division + +[Term] +id: GO:0003425 +name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division +namespace: biological_process +def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0000132 ! establishment of mitotic spindle orientation +is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division +is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity + +[Term] +id: GO:0003426 +name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity +relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division + +[Term] +id: GO:0003427 +name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +is_a: GO:0051493 ! regulation of cytoskeleton organization +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division + +[Term] +id: GO:0003428 +name: chondrocyte intercalation involved in growth plate cartilage morphogenesis +namespace: biological_process +def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis +relationship: part_of GO:0060029 ! convergent extension involved in organogenesis + +[Term] +id: GO:0003429 +name: growth plate cartilage chondrocyte morphogenesis +namespace: biological_process +def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis +is_a: GO:0003422 ! growth plate cartilage morphogenesis +relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation + +[Term] +id: GO:0003430 +name: growth plate cartilage chondrocyte growth +namespace: biological_process +def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003415 ! chondrocyte hypertrophy +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development + +[Term] +id: GO:0003431 +name: growth plate cartilage chondrocyte development +namespace: biological_process +def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis +relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation + +[Term] +id: GO:0003432 +name: cell growth involved in growth plate cartilage chondrocyte morphogenesis +namespace: biological_process +def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003430 ! growth plate cartilage chondrocyte growth +relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis + +[Term] +id: GO:0003433 +name: chondrocyte development involved in endochondral bone morphogenesis +namespace: biological_process +def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0002063 ! chondrocyte development +relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis + +[Term] +id: GO:0003434 +name: BMP signaling pathway involved in growth plate cartilage chondrocyte development +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development + +[Term] +id: GO:0003435 +name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] +is_a: GO:0007224 ! smoothened signaling pathway +relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development + +[Term] +id: GO:0003436 +name: regulation of cell adhesion involved in growth plate cartilage morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis + +[Term] +id: GO:0003437 +name: regulation of cell communication involved in growth plate cartilage morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis + +[Term] +id: GO:0003673 +name: obsolete Gene_Ontology +namespace: biological_process +def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "Gene_Ontology" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003674 +name: molecular_function +namespace: molecular_function +alt_id: GO:0005554 +def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] +comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "molecular function" EXACT [] + +[Term] +id: GO:0003675 +name: obsolete protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003676 +name: nucleic acid binding +namespace: molecular_function +alt_id: GO:0000496 +def: "Binding to a nucleic acid." [GOC:jl] +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "base pairing" NARROW [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0003677 +name: DNA binding +namespace: molecular_function +alt_id: GO:0043566 +def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_plant +subset: goslim_yeast +synonym: "microtubule/chromatin interaction" RELATED [] +synonym: "plasmid binding" NARROW [] +synonym: "structure specific DNA binding" RELATED [] +synonym: "structure-specific DNA binding" RELATED [] +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0003678 +name: DNA helicase activity +namespace: molecular_function +alt_id: GO:0003679 +alt_id: GO:0004003 +def: "Unwinding of a DNA helix, driven by ATP hydrolysis." [EC:3.6.4.12, GOC:jl] +synonym: "ATP-dependent DNA helicase activity" EXACT [] +xref: EC:3.6.4.12 +xref: Reactome:R-HSA-5693589 "D-loop dissociation and strand annealing" +is_a: GO:0004386 ! helicase activity +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0003680 +name: minor groove of adenine-thymine-rich DNA binding +namespace: molecular_function +def: "Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins." [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564] +synonym: "AT binding" EXACT [] +synonym: "AT DNA binding" EXACT [] +synonym: "AT-rich DNA binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0003681 +name: bent DNA binding +namespace: molecular_function +def: "Binding to DNA in a bent conformation." [GOC:jl, PMID:12627977] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0003682 +name: chromatin binding +namespace: molecular_function +def: "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "lamin/chromatin binding" NARROW [] +synonym: "microtubule/chromatin interaction" NARROW [] +synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0003683 +name: obsolete lamin/chromatin binding +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two functions. +synonym: "lamin/chromatin binding" EXACT [] +is_obsolete: true +consider: GO:0003682 +consider: GO:0005521 + +[Term] +id: GO:0003684 +name: damaged DNA binding +namespace: molecular_function +def: "Binding to damaged DNA." [GOC:jl] +synonym: "DNA repair enzyme" RELATED [] +synonym: "DNA repair protein" RELATED [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0003685 +name: obsolete DNA repair protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it includes a process term. +synonym: "DNA repair protein" EXACT [] +is_obsolete: true +consider: GO:0003684 + +[Term] +id: GO:0003686 +name: obsolete DNA repair enzyme +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it includes a process term. +synonym: "DNA repair enzyme" EXACT [] +is_obsolete: true +consider: GO:0003684 + +[Term] +id: GO:0003687 +name: obsolete DNA replication factor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +synonym: "DNA replication factor" EXACT [] +is_obsolete: true +consider: GO:0006260 + +[Term] +id: GO:0003688 +name: DNA replication origin binding +namespace: molecular_function +def: "Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] +synonym: "ARS binding" NARROW [] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0003689 +name: DNA clamp loader activity +namespace: molecular_function +alt_id: GO:0033170 +def: "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis." [GOC:mah, GOC:vw, PMID:16082778] +synonym: "DNA clamp loading ATPase activity" EXACT [] +synonym: "DNA-protein loading ATPase activity" RELATED [GOC:mah] +synonym: "PCNA loading activity" NARROW [] +synonym: "PCNA loading complex activity" NARROW [] +synonym: "protein-DNA loading ATPase activity" RELATED [] +xref: Reactome:R-HSA-174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" +xref: Reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0003690 +name: double-stranded DNA binding +namespace: molecular_function +def: "Binding to double-stranded DNA." [GOC:elh, GOC:vw] +synonym: "dsDNA binding" EXACT [GOC:elh] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0003691 +name: double-stranded telomeric DNA binding +namespace: molecular_function +def: "Binding to double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] +is_a: GO:0003690 ! double-stranded DNA binding +is_a: GO:0042162 ! telomeric DNA binding + +[Term] +id: GO:0003692 +name: left-handed Z-DNA binding +namespace: molecular_function +def: "Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0003693 +name: P-element binding +namespace: molecular_function +def: "Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0003694 +name: obsolete plasmid binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732] +comment: This term was made obsolete because it refers to component information. +synonym: "plasmid binding" EXACT [] +synonym: "plasmid-associated protein" RELATED [] +is_obsolete: true +consider: GO:0003677 +consider: GO:0005727 + +[Term] +id: GO:0003695 +name: obsolete random coil DNA binding +namespace: molecular_function +alt_id: GO:0016017 +def: "OBSOLETE. Binding to DNA in a random coil configuration." [GOC:mah] +comment: This term was obsoleted because the definition was not clear enough as to what is directing specificity of the binding to the DNA. +synonym: "random coil binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003696 +name: satellite DNA binding +namespace: molecular_function +def: "Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0003697 +name: single-stranded DNA binding +namespace: molecular_function +alt_id: GO:0003698 +alt_id: GO:0003699 +def: "Binding to single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] +comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. +synonym: "ssDNA binding" EXACT [GOC:mah] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0003700 +name: DNA-binding transcription factor activity +namespace: molecular_function +alt_id: GO:0000130 +alt_id: GO:0001071 +alt_id: GO:0001130 +alt_id: GO:0001131 +alt_id: GO:0001151 +alt_id: GO:0001199 +alt_id: GO:0001204 +def: "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] +comment: Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions. +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_plant +subset: goslim_yeast +synonym: "bacterial-type DNA binding transcription factor activity" NARROW [] +synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] +synonym: "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW [] +synonym: "DNA binding transcription factor activity" EXACT [] +synonym: "gene-specific transcription factor activity" EXACT [] +synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] +synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW [] +synonym: "nucleic acid binding transcription factor activity" BROAD [] +synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] +synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "transcription factor activity" BROAD [] +synonym: "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] +synonym: "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] +synonym: "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW [] +synonym: "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0003701 +name: obsolete RNA polymerase I transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "RNA polymerase I transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0001181 +consider: GO:0006360 + +[Term] +id: GO:0003702 +name: obsolete RNA polymerase II transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "RNA polymerase II transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0000981 +consider: GO:0006366 + +[Term] +id: GO:0003704 +name: obsolete specific RNA polymerase II transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] +comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "specific RNA polymerase II transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0000981 +consider: GO:0006366 + +[Term] +id: GO:0003706 +name: obsolete ligand-regulated transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators] +comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. +synonym: "ligand-regulated transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0004879 +consider: GO:0030374 + +[Term] +id: GO:0003707 +name: steroid hormone receptor activity +namespace: molecular_function +def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] +comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0003709 +name: obsolete RNA polymerase III transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "RNA polymerase III transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0000995 +consider: GO:0006383 + +[Term] +id: GO:0003711 +name: transcription elongation regulator activity +namespace: molecular_function +def: "A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription." [GOC:txnOH-2018, PMID:23878398, PMID:28892040] +comment: Restored term from obsolete. +synonym: "transcription elongation factor activity" EXACT [] +synonym: "transcriptional elongation regulator activity" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0003712 +name: transcription coregulator activity +namespace: molecular_function +alt_id: GO:0001104 +alt_id: GO:0016455 +def: "A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] +comment: Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity. +subset: goslim_drosophila +synonym: "RNA polymerase II transcriptional cofactor activity" RELATED [] +synonym: "transcription cofactor activity" EXACT [] +synonym: "transcriptional co-regulator" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0003713 +name: transcription coactivator activity +namespace: molecular_function +alt_id: GO:0001105 +def: "A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] +comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. +synonym: "RNA polymerase II transcription co-activator activity" RELATED [] +synonym: "RNA polymerase II transcription coactivator activity" RELATED [] +synonym: "RNA polymerase II transcription mediator activity" RELATED [] +synonym: "transcription co-activator activity" EXACT [] +is_a: GO:0003712 ! transcription coregulator activity + +[Term] +id: GO:0003714 +name: transcription corepressor activity +namespace: molecular_function +alt_id: GO:0001106 +def: "A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] +comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. +synonym: "RNA polymerase II transcription co-repressor activity" RELATED [] +synonym: "RNA polymerase II transcription corepressor activity" RELATED [] +synonym: "transcription co-repressor activity" EXACT [] +is_a: GO:0003712 ! transcription coregulator activity + +[Term] +id: GO:0003715 +name: obsolete transcription termination factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "transcription termination factor activity" EXACT [] +synonym: "transcriptional termination factor activity" EXACT [] +is_obsolete: true +consider: GO:0006353 + +[Term] +id: GO:0003716 +name: obsolete RNA polymerase I transcription termination factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol I transcription termination factor activity" EXACT [] +synonym: "RNA polymerase I transcription termination factor activity" EXACT [] +is_obsolete: true +consider: GO:0006363 + +[Term] +id: GO:0003717 +name: obsolete RNA polymerase II transcription termination factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol II transcription termination factor activity" EXACT [] +synonym: "RNA polymerase II transcription termination factor activity" EXACT [] +is_obsolete: true +consider: GO:0006369 + +[Term] +id: GO:0003718 +name: obsolete RNA polymerase III transcription termination factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol III transcription termination factor activity" EXACT [] +synonym: "RNA polymerase III transcription termination factor activity" EXACT [] +is_obsolete: true +consider: GO:0006386 + +[Term] +id: GO:0003719 +name: obsolete transcription factor binding, cytoplasmic sequestering +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because sequestering is a process rather than a function. +synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] +is_obsolete: true +replaced_by: GO:0042994 + +[Term] +id: GO:0003720 +name: telomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc, PMID:28732250] +xref: Reactome:R-HSA-163090 "Elongation Of The Telomeric Chromosome End" +xref: Reactome:R-HSA-164617 "Elongation of Extended Telomeric Chromosome End" +is_a: GO:0003964 ! RNA-directed DNA polymerase activity + +[Term] +id: GO:0003721 +name: telomerase RNA reverse transcriptase activity +namespace: molecular_function +def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] +synonym: "telomerase, catalyst" EXACT [] +is_a: GO:0003964 ! RNA-directed DNA polymerase activity +relationship: part_of GO:0003720 ! telomerase activity + +[Term] +id: GO:0003723 +name: RNA binding +namespace: molecular_function +alt_id: GO:0000498 +alt_id: GO:0044822 +def: "Binding to an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_plant +subset: goslim_yeast +synonym: "base pairing with RNA" NARROW [] +synonym: "poly(A) RNA binding" RELATED [] +synonym: "poly(A)-RNA binding" RELATED [] +synonym: "poly-A RNA binding" RELATED [] +xref: Reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0003724 +name: RNA helicase activity +namespace: molecular_function +alt_id: GO:0004004 +def: "Unwinding of an RNA helix, driven by ATP hydrolysis." [GOC:jl, PMID:19158098] +synonym: "ATP-dependent RNA helicase activity" EXACT [] +xref: EC:3.6.4.13 +xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN +xref: Reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases" +is_a: GO:0004386 ! helicase activity +is_a: GO:0008186 ! ATP-dependent activity, acting on RNA +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0003725 +name: double-stranded RNA binding +namespace: molecular_function +def: "Binding to double-stranded RNA." [GOC:jl] +synonym: "dsRNA binding" EXACT [GOC:ecd] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003726 +name: double-stranded RNA adenosine deaminase activity +namespace: molecular_function +alt_id: GO:0003971 +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] +synonym: "double-stranded RNA specific editase activity" RELATED [] +xref: Reactome:R-HSA-77614 "Deamination at C6 position of adenosine in Editosome (ADAR1)" +xref: Reactome:R-HSA-77615 "Deamination at C6 position of adenosine in Editosome (ADAR2)" +is_a: GO:0004000 ! adenosine deaminase activity + +[Term] +id: GO:0003727 +name: single-stranded RNA binding +namespace: molecular_function +alt_id: GO:0003728 +def: "Binding to single-stranded RNA." [GOC:jl] +synonym: "ssRNA binding" EXACT [GOC:mah] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003729 +name: mRNA binding +namespace: molecular_function +alt_id: GO:0000499 +def: "Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] +subset: goslim_chembl +subset: goslim_yeast +synonym: "base pairing with mRNA" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0003730 +name: mRNA 3'-UTR binding +namespace: molecular_function +def: "Binding to a 3' untranslated region of an mRNA molecule." [GOC:mah] +synonym: "mRNA 3' UTR binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0003731 +name: obsolete mRNA cap binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] +comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. +synonym: "mRNA cap binding" EXACT [] +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0003732 +name: obsolete snRNA cap binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] +comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. +synonym: "snRNA cap binding" EXACT [] +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0003733 +name: obsolete ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "ribonucleoprotein" EXACT [] +is_obsolete: true +replaced_by: GO:1990904 + +[Term] +id: GO:0003734 +name: obsolete small nuclear ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "small nuclear ribonucleoprotein" EXACT [] +synonym: "snRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0030532 + +[Term] +id: GO:0003735 +name: structural constituent of ribosome +namespace: molecular_function +alt_id: GO:0003736 +alt_id: GO:0003737 +alt_id: GO:0003738 +alt_id: GO:0003739 +alt_id: GO:0003740 +alt_id: GO:0003741 +alt_id: GO:0003742 +def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] +comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_yeast +synonym: "ribosomal protein" BROAD [] +synonym: "ribosomal RNA" RELATED [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0003743 +name: translation initiation factor activity +namespace: molecular_function +alt_id: GO:0003744 +alt_id: GO:0003745 +def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] +xref: Reactome:R-HSA-72621 "Ribosomal scanning" +xref: Reactome:R-HSA-72697 "Start codon recognition" +xref: Reactome:R-HSA-72722 "eIF2 activation" +is_a: GO:0008135 ! translation factor activity, RNA binding + +[Term] +id: GO:0003746 +name: translation elongation factor activity +namespace: molecular_function +alt_id: GO:0008182 +alt_id: GO:0008183 +def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] +xref: Reactome:R-HSA-192704 "Synthesis of PB1-F2" +xref: Reactome:R-HSA-192841 "Viral Protein Synthesis" +is_a: GO:0008135 ! translation factor activity, RNA binding + +[Term] +id: GO:0003747 +name: translation release factor activity +namespace: molecular_function +alt_id: GO:0003748 +alt_id: GO:0003749 +def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] +is_a: GO:0008079 ! translation termination factor activity + +[Term] +id: GO:0003750 +name: obsolete cell cycle regulator +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a single molecular function. +synonym: "cell cycle regulator" EXACT [] +is_obsolete: true +replaced_by: GO:0051726 + +[Term] +id: GO:0003754 +name: obsolete chaperone activity +namespace: molecular_function +alt_id: GO:0003757 +alt_id: GO:0003758 +alt_id: GO:0003760 +alt_id: GO:0003761 +def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] +comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. +synonym: "chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0044183 +consider: GO:0051082 + +[Term] +id: GO:0003755 +name: peptidyl-prolyl cis-trans isomerase activity +namespace: molecular_function +alt_id: GO:0004752 +alt_id: GO:0042028 +def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] +synonym: "cis-trans proline isomerase activity" EXACT [] +synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] +synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] +synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] +synonym: "immunophilin" RELATED [] +synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] +synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] +synonym: "parvulin" RELATED [] +synonym: "peptide bond isomerase activity" RELATED [EC:5.2.1.8] +synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] +synonym: "peptidylproline cis-trans-isomerase activity" RELATED [EC:5.2.1.8] +synonym: "peptidylprolyl cis-trans isomerase activity" RELATED [EC:5.2.1.8] +synonym: "peptidylprolyl isomerase activity" RELATED [EC:5.2.1.8] +synonym: "PPIase activity" RELATED [EC:5.2.1.8] +synonym: "rotamase activity" RELATED [EC:5.2.1.8] +xref: EC:5.2.1.8 +xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN +xref: Reactome:R-HSA-2022073 "Procollagen triple helix formation" +xref: Reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1" +xref: RHEA:16237 +is_a: GO:0016859 ! cis-trans isomerase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0003756 +name: protein disulfide isomerase activity +namespace: molecular_function +alt_id: GO:0006467 +def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function] +synonym: "disulphide bond biosynthesis" EXACT [] +synonym: "disulphide bond formation" EXACT [] +synonym: "protein cysteine-thiol oxidation" RELATED [] +synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] +synonym: "protein disulfide-isomerase reaction" RELATED [EC:5.3.4.1] +synonym: "protein disulphide isomerase activity" EXACT [] +synonym: "protein thiol-disulfide exchange" EXACT [] +synonym: "protein thiol-disulphide exchange" EXACT [] +synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] +xref: EC:5.3.4.1 +xref: MetaCyc:5.3.4.1-RXN +xref: Reactome:R-HSA-8950113 "IL12A binds IL12B" +xref: Reactome:R-HSA-8950183 "IL12B binds IL23A" +xref: Reactome:R-HSA-8950456 "IL12B dimerizes" +is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0003759 +name: obsolete glycoprotein-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +synonym: "glycoprotein-specific chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0044183 +consider: GO:0051082 + +[Term] +id: GO:0003762 +name: obsolete histone-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +synonym: "histone-specific chaperone activity" EXACT [] +synonym: "nucleosome assembly chaperone" EXACT [] +is_obsolete: true +consider: GO:0006333 +consider: GO:0006334 +consider: GO:0034728 +consider: GO:0042393 +consider: GO:0043486 +consider: GO:0044183 +consider: GO:0051082 + +[Term] +id: GO:0003763 +name: obsolete chaperonin ATPase activity +namespace: molecular_function +alt_id: GO:0003764 +alt_id: GO:0003765 +alt_id: GO:0003766 +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +synonym: "chaperonin" EXACT [] +synonym: "chaperonin ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016887 +consider: GO:0006457 + +[Term] +id: GO:0003767 +name: obsolete co-chaperone activity +namespace: molecular_function +alt_id: GO:0003768 +alt_id: GO:0003769 +alt_id: GO:0003770 +alt_id: GO:0003771 +def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +synonym: "co-chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0044183 +consider: GO:0051087 + +[Term] +id: GO:0003772 +name: obsolete co-chaperonin activity +namespace: molecular_function +def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +synonym: "co-chaperonin activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0044183 +consider: GO:0051087 + +[Term] +id: GO:0003773 +name: obsolete heat shock protein activity +namespace: molecular_function +def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. +synonym: "heat shock protein activity" EXACT [] +is_obsolete: true +consider: GO:0006986 +consider: GO:0042026 + +[Term] +id: GO:0003774 +name: cytoskeletal motor activity +namespace: molecular_function +def: "Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force)." [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +synonym: "motor activity" BROAD [] +xref: Reactome:R-HSA-1861595 "Extension of pseudopodia by myosin-X in a PI3K dependent manner" +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0003775 +name: obsolete axonemal motor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes cellular component information. +synonym: "axonemal motor activity" EXACT [] +is_obsolete: true +consider: GO:0003777 +consider: GO:0005930 + +[Term] +id: GO:0003776 +name: obsolete muscle motor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes anatomy information. +synonym: "muscle motor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0000146 +consider: GO:0006936 +consider: GO:0043292 + +[Term] +id: GO:0003777 +name: microtubule motor activity +namespace: molecular_function +alt_id: GO:1990939 +def: "A motor activity that generates movement along a microtubule, driven by ATP hydrolysis." [PMID:19686686, PMID:32684327, PMID:32842864] +comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. +synonym: "ATP-dependent microtubule motor activity" EXACT [] +synonym: "axonemal motor activity" NARROW [] +synonym: "dynein" BROAD [] +synonym: "dynein ATPase activity" NARROW [] +synonym: "kinesin" BROAD [] +synonym: "kinesin motor activity" NARROW [] +synonym: "kinetochore motor activity" NARROW [] +xref: Reactome:R-HSA-177479 "Axonal transport of NGF:Trk complexes" +xref: Reactome:R-HSA-265160 "Insulin secretory granule translocates to cell cortex" +xref: Reactome:R-HSA-9610627 "KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane" +is_a: GO:0003774 ! cytoskeletal motor activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0003778 +name: obsolete dynactin motor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. +synonym: "dynactin motor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003779 +name: actin binding +namespace: molecular_function +def: "Binding to monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] +synonym: "membrane associated actin binding" NARROW [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0003780 +name: obsolete actin cross-linking activity +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] +comment: This term was made obsolete because it represents a combination of molecular functions. +synonym: "actin cross-linking activity" EXACT [] +is_obsolete: true +consider: GO:0030674 +consider: GO:0051015 + +[Term] +id: GO:0003781 +name: obsolete actin bundling activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +synonym: "actin bundling activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051017 + +[Term] +id: GO:0003782 +name: obsolete F-actin capping activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +synonym: "F-actin capping activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051016 + +[Term] +id: GO:0003783 +name: obsolete barbed-end actin capping activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +synonym: "barbed-end actin capping activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051016 + +[Term] +id: GO:0003784 +name: obsolete barbed-end actin capping/severing activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes two biological processes. +synonym: "barbed-end actin capping/severing activity" EXACT [] +is_obsolete: true +consider: GO:0051014 +consider: GO:0051016 + +[Term] +id: GO:0003785 +name: actin monomer binding +namespace: molecular_function +def: "Binding to monomeric actin, also known as G-actin." [GOC:ai] +synonym: "G actin binding" EXACT [] +is_a: GO:0003779 ! actin binding + +[Term] +id: GO:0003786 +name: actin lateral binding +namespace: molecular_function +def: "Binding to an actin filament along its length." [GOC:mah] +is_a: GO:0051015 ! actin filament binding + +[Term] +id: GO:0003787 +name: obsolete actin depolymerizing activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +synonym: "actin depolymerizing activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030042 + +[Term] +id: GO:0003788 +name: obsolete actin monomer sequestering activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because sequestering is a process, not an activity. +synonym: "actin monomer sequestering activity" EXACT [] +is_obsolete: true +replaced_by: GO:0042989 + +[Term] +id: GO:0003789 +name: obsolete actin filament severing activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +synonym: "actin filament severing activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051014 + +[Term] +id: GO:0003790 +name: obsolete actin modulating activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not make sense. +synonym: "actin modulating activity" EXACT [] +is_obsolete: true +consider: GO:0030036 + +[Term] +id: GO:0003791 +name: obsolete membrane associated actin binding +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "membrane associated actin binding" EXACT [] +is_obsolete: true +consider: GO:0003779 +consider: GO:0016020 + +[Term] +id: GO:0003792 +name: obsolete regulation of actin thin filament length activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the term belongs in the process ontology. +synonym: "regulation of actin thin filament length activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030832 + +[Term] +id: GO:0003793 +name: obsolete defense/immunity protein activity +namespace: molecular_function +def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "defence/immunity protein activity" EXACT [] +synonym: "defense/immunity protein activity" EXACT [] +is_obsolete: true +consider: GO:0006952 + +[Term] +id: GO:0003794 +name: obsolete acute-phase response protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "acute-phase response protein activity" EXACT [] +is_obsolete: true +consider: GO:0006953 + +[Term] +id: GO:0003795 +name: obsolete antimicrobial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "antimicrobial peptide activity" EXACT [] +is_obsolete: true +consider: GO:0019730 + +[Term] +id: GO:0003796 +name: lysozyme activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813] +synonym: "1,4-N-acetylmuramidase activity" EXACT [] +synonym: "globulin G" RELATED [EC:3.2.1.17] +synonym: "globulin G1" RELATED [EC:3.2.1.17] +synonym: "L-7001" RELATED [EC:3.2.1.17] +synonym: "lysozyme g" RELATED [EC:3.2.1.17] +synonym: "mucopeptide glucohydrolase activity" EXACT [] +synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] +synonym: "muramidase activity" EXACT [] +synonym: "N,O-diacetylmuramidase activity" EXACT [] +synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" RELATED [EC:3.2.1.17] +synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] +xref: EC:3.2.1.17 +xref: MetaCyc:3.2.1.17-RXN +xref: Reactome:R-HSA-8862320 "LYZ hydrolyzes peptidoglycans in the bacterial cell wall" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0061783 ! peptidoglycan muralytic activity + +[Term] +id: GO:0003797 +name: obsolete antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "antibacterial peptide activity" EXACT [] +is_obsolete: true +consider: GO:0042742 + +[Term] +id: GO:0003798 +name: obsolete male-specific antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "male-specific antibacterial peptide activity" EXACT [] +is_obsolete: true +consider: GO:0050831 + +[Term] +id: GO:0003799 +name: obsolete antifungal peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "antifungal peptide activity" EXACT [] +is_obsolete: true +consider: GO:0050832 + +[Term] +id: GO:0003800 +name: obsolete antiviral response protein activity +namespace: molecular_function +def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "antiviral response protein activity" EXACT [] +is_obsolete: true +consider: GO:0009615 + +[Term] +id: GO:0003801 +name: obsolete blood coagulation factor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "blood coagulation factor activity" EXACT [] +is_obsolete: true +consider: GO:0004252 +consider: GO:0007596 + +[Term] +id: GO:0003802 +name: obsolete coagulation factor VIIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [PMID:12496253] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor VII" RELATED [] +synonym: "blood coagulation factor VII activity" EXACT [] +synonym: "blood-coagulation factor VIIa" RELATED [] +synonym: "coagulation factor VIIa activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003803 +name: obsolete coagulation factor IXa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor XI" RELATED [] +synonym: "activated blood-coagulation factor IX" RELATED [] +synonym: "activated christmas factor" RELATED [] +synonym: "autoprothrombin II" RELATED [] +synonym: "blood coagulation factor IX activity" EXACT [] +synonym: "blood platelet cofactor II" RELATED [] +synonym: "blood-coagulation factor IXa" RELATED [] +synonym: "Christmas factor activity" RELATED [] +synonym: "coagulation factor IXa activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003804 +name: obsolete coagulation factor Xa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [GOC:jl, PMID:7354023] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor X" RELATED [] +synonym: "activated factor X" RELATED [] +synonym: "activated Stuart-Prower factor" RELATED [] +synonym: "autoprothrombin C" RELATED [] +synonym: "blood coagulation factor X activity" EXACT [] +synonym: "coagulation factor Xa activity" EXACT [] +synonym: "factor Xa" RELATED [] +synonym: "plasma thromboplastin" RELATED [] +synonym: "prothrombase activity" RELATED [] +synonym: "prothrombinase activity" RELATED [] +synonym: "Stuart factor" RELATED [] +synonym: "Stuart factor activity" RELATED [] +synonym: "thrombokinase activity" RELATED [] +synonym: "thromboplastin" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003805 +name: obsolete coagulation factor XIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor XI" RELATED [] +synonym: "activated plasma thromboplastin antecedent" RELATED [] +synonym: "blood coagulation factor XI activity" EXACT [] +synonym: "blood-coagulation factor XIa" RELATED [] +synonym: "coagulation factor XIa activity" EXACT [] +synonym: "plasma thromboplastin antecedent activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003806 +name: obsolete coagulation factor XIIa activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated beta blood-coagulation factor XII" RELATED [] +synonym: "blood coagulation factor XII activity" EXACT [] +synonym: "blood-coagulation factor XIIabeta" RELATED [] +synonym: "blood-coagulation factor XIIf" RELATED [] +synonym: "coagulation factor XIIa activity" EXACT [] +synonym: "hageman factor (activated)" RELATED [] +synonym: "hageman factor activity" RELATED [] +synonym: "hageman factor beta-fragment" RELATED [] +synonym: "hageman factor fragment HFf" RELATED [] +synonym: "kallikreinogen activator" RELATED [] +synonym: "prealbumin activator" RELATED [] +synonym: "prekallikrein activator" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003807 +name: obsolete plasma kallikrein activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "callicrein" RELATED [] +synonym: "depot-padutin" RELATED [] +synonym: "dilminal D" RELATED [] +synonym: "glumorin" RELATED [] +synonym: "kallidinogenase" BROAD [] +synonym: "kallikrein" RELATED [] +synonym: "kallikrein I" RELATED [] +synonym: "kallikrein II" RELATED [] +synonym: "kininogenase" BROAD [] +synonym: "kininogenin activity" RELATED [] +synonym: "onokrein P" RELATED [] +synonym: "padreatin" RELATED [] +synonym: "padutin" RELATED [] +synonym: "panceatic kallikrein" RELATED [] +synonym: "plasma kallikrein activity" EXACT [] +synonym: "serum kallikrein activity" RELATED [] +synonym: "urinary kallikrein" RELATED [] +synonym: "urokallikrein" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003808 +name: obsolete protein C (activated) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood coagulation factor XIV activity" RELATED [] +synonym: "activated protein C" RELATED [] +synonym: "autoprothrombin II-A" RELATED [] +synonym: "autoprothrombin IIA activity" RELATED [] +synonym: "blood-coagulation factor XIVa" RELATED [] +synonym: "GSAPC" RELATED [] +synonym: "protein C (activated) activity" EXACT [] +synonym: "protein Ca" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003809 +name: obsolete thrombin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated blood-coagulation factor II" RELATED [] +synonym: "beta-thrombin" RELATED [] +synonym: "blood-coagulation factor IIa" RELATED [] +synonym: "E thrombin" RELATED [] +synonym: "factor IIa" RELATED [] +synonym: "fibrinogenase activity" RELATED [] +synonym: "gamma-thrombin" RELATED [] +synonym: "thrombase activity" RELATED [] +synonym: "thrombin activity" EXACT [] +synonym: "thrombin-C" RELATED [] +synonym: "thrombofort" RELATED [] +synonym: "topical" RELATED [] +synonym: "tropostasin" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003810 +name: protein-glutamine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] +synonym: "factor XIIIa" RELATED [EC:2.3.2.13] +synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] +synonym: "fibrinoligase activity" EXACT [] +synonym: "glutaminylpeptide gamma-glutamyltransferase activity" RELATED [EC:2.3.2.13] +synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] +synonym: "protein-glutamine:amine gamma-glutamyltransferase" RELATED [EC:2.3.2.13] +synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" RELATED [EC:2.3.2.13] +synonym: "TGase activity" EXACT [] +synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] +synonym: "transglutaminase activity" EXACT [] +xref: EC:2.3.2.13 +xref: MetaCyc:2.3.2.13-RXN +xref: Reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+" +xref: Reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking" +xref: RESID:AA0124 +xref: RHEA:54816 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0003811 +name: obsolete complement activity +namespace: molecular_function +def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] +comment: This term was made obsolete because it refers to involvement in a biological process. +synonym: "complement activity" EXACT [] +is_obsolete: true +consider: GO:0006956 + +[Term] +id: GO:0003812 +name: obsolete alternative-complement-pathway C3/C5 convertase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "(C3b)n,Bb" RELATED [] +synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [] +synonym: "alternative complement pathway C3(C5) convertase activity" RELATED [] +synonym: "alternative-complement-pathway C3/C5 convertase activity" EXACT [] +synonym: "C3 convertase activity" BROAD [] +synonym: "C3 proactivator" RELATED [] +synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" RELATED [] +synonym: "C5 convertase activity" BROAD [] +synonym: "cobra venom factor-dependent C3 convertase" NARROW [] +synonym: "complement C 3(C 5) convertase (amplification)" RELATED [] +synonym: "complement component C3/C5 convertase (alternative) activity" RELATED [] +synonym: "complement factor B activity" RELATED [] +synonym: "CVF,Bb" RELATED [] +synonym: "glycine-rich beta-glycoprotein" RELATED [] +synonym: "heat-labile factor" RELATED [] +synonym: "proenzyme factor B" EXACT [] +synonym: "properdin factor B activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003813 +name: obsolete classical-complement-pathway C3/C5 convertase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "C3 convertase activity" BROAD [] +synonym: "C42" RELATED [] +synonym: "C423" RELATED [] +synonym: "C4b,2a" RELATED [] +synonym: "C4b,2a,3b" RELATED [] +synonym: "C5 convertase activity" BROAD [] +synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT [] +synonym: "complement C2 activity" BROAD [] +synonym: "complement C3 convertase activity" RELATED [] +synonym: "complement C42" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003815 +name: obsolete complement component C1r activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated complement C1r" RELATED [] +synonym: "C1r esterase activity" RELATED [] +synonym: "complement component C1r activity" EXACT [] +synonym: "complement subcomponent C1r" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003816 +name: obsolete complement component C1s activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "activated complement C1s" RELATED [] +synonym: "C1 esterase activity" RELATED [] +synonym: "C1s esterase activity" RELATED [] +synonym: "complement C1s" RELATED [] +synonym: "complement component C1s activity" EXACT [] +synonym: "complement subcomponent C1s" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003817 +name: obsolete complement factor D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "adipsin" EXACT [] +synonym: "C3 convertase activator activity" RELATED [] +synonym: "C3 proactivator convertase activity" RELATED [] +synonym: "complement factor D activity" EXACT [] +synonym: "factor D" RELATED [] +synonym: "factor D (complement)" RELATED [] +synonym: "properdin factor D esterase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003818 +name: obsolete complement factor I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "C3b inactivator activity" NARROW [] +synonym: "C3b/C4b inactivator activity" RELATED [] +synonym: "C3bINA" RELATED [] +synonym: "complement C3b inactivator" RELATED [] +synonym: "complement C3b/C4b inactivator" RELATED [] +synonym: "complement C4b inactivator" RELATED [] +synonym: "complement C4bi" RELATED [] +synonym: "complement component C3b inactivator activity" RELATED [] +synonym: "complement factor I activity" EXACT [] +synonym: "conglutinogen-activating factor C" RELATED [] +synonym: "factor I" RELATED [EC:3.4.21.45] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0003819 +name: obsolete major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "major histocompatibility complex antigen" EXACT [] +synonym: "MHC protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003820 +name: obsolete class I major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "class I major histocompatibility complex antigen" EXACT [] +is_obsolete: true +consider: GO:0042612 + +[Term] +id: GO:0003821 +name: obsolete class II major histocompatibility complex antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "class II major histocompatibility complex antigen" EXACT [] +is_obsolete: true +consider: GO:0042613 + +[Term] +id: GO:0003822 +name: obsolete MHC-interacting protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "MHC-interacting protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003823 +name: antigen binding +namespace: molecular_function +def: "Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544] +subset: goslim_chembl +subset: goslim_pir +synonym: "antibody" RELATED [] +synonym: "B cell receptor activity" RELATED [] +synonym: "immunoglobulin" RELATED [] +synonym: "opsonin activity" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0003824 +name: catalytic activity +namespace: molecular_function +def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] +xref: Wikipedia:Enzyme +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0003825 +name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15] +synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" RELATED [EC:2.4.1.15] +synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" RELATED [EC:2.4.1.15] +synonym: "transglucosylase activity" EXACT [] +synonym: "trehalose 6-phosphate synthase activity" EXACT [] +synonym: "trehalose 6-phosphate synthetase activity" EXACT [] +synonym: "trehalose phosphate synthase activity" RELATED [EC:2.4.1.15] +synonym: "trehalose phosphate synthetase activity" RELATED [EC:2.4.1.15] +synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.15] +synonym: "trehalose-P synthetase activity" RELATED [EC:2.4.1.15] +synonym: "trehalose-phosphate synthase activity" EXACT [] +synonym: "trehalose-phosphate synthetase activity" EXACT [] +synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] +synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" RELATED [EC:2.4.1.15] +synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.15] +synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.15] +synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.15] +xref: EC:2.4.1.15 +xref: MetaCyc:TREHALOSE6PSYN-RXN +xref: RHEA:18889 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003827 +name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11456] +synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101] +synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101] +synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "GnTI" RELATED [EC:2.4.1.101] +synonym: "GNTI activity" RELATED [EC:2.4.1.101] +synonym: "N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101] +synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.101] +synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101] +synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.101] +synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.101] +xref: EC:2.4.1.101 +xref: KEGG_REACTION:R05983 +xref: MetaCyc:2.4.1.101-RXN +xref: Reactome:R-HSA-964768 "Addition of GlcNAc to the glycan on the A arm" +xref: RHEA:11456 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0003828 +name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8] +synonym: "alpha-2,8-sialyltransferase activity" RELATED [EC:2.4.99.8] +synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] +synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.8] +synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" RELATED [EC:2.4.99.8] +synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" RELATED [EC:2.4.99.8] +synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] +synonym: "ganglioside GD3 synthase activity" RELATED [EC:2.4.99.8] +synonym: "ganglioside GD3 synthetase sialyltransferase activity" RELATED [EC:2.4.99.8] +synonym: "GD3 synthase activity" RELATED [EC:2.4.99.8] +synonym: "SAT-2" RELATED [EC:2.4.99.8] +xref: EC:2.4.99.8 +xref: MetaCyc:2.4.99.8-RXN +xref: Reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans" +xref: Reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues" +xref: Reactome:R-HSA-422454 "Polysialylation of NCAM1" +xref: RHEA:19313 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003829 +name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] +synonym: "beta(6)-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.102] +synonym: "beta6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.102] +synonym: "core 2 acetylglucosaminyltransferase activity" RELATED [] +synonym: "core 6-beta-GlcNAc-transferase A" RELATED [] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" RELATED [EC:2.4.1.102] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED [] +synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" RELATED [] +synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" RELATED [] +xref: EC:2.4.1.102 +xref: MetaCyc:2.4.1.102-RXN +xref: Reactome:R-HSA-914012 "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins" +xref: Reactome:R-HSA-914018 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein" +xref: RHEA:18705 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0003830 +name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] +synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.144] +synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.144] +synonym: "GnTIII activity" RELATED [EC:2.4.1.144] +synonym: "N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.144] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.144] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] +xref: EC:2.4.1.144 +xref: MetaCyc:2.4.1.144-RXN +xref: Reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3" +xref: RHEA:15509 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0003831 +name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] +synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "GalT activity" RELATED [EC:2.4.1.38] +synonym: "glycoprotein 4-beta-galactosyl-transferase activity" RELATED [EC:2.4.1.38] +synonym: "glycoprotein 4-beta-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "glycoprotein beta-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] +synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] +synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.38] +synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" RELATED [EC:2.4.1.38] +xref: EC:2.4.1.38 +xref: MetaCyc:2.4.1.38-RXN +xref: Reactome:R-HSA-1912352 "Galactosylation of Pre-NOTCH" +xref: Reactome:R-HSA-2025723 "B4GALTs transfer Gal to the N-glycan precursor" +xref: Reactome:R-HSA-2046265 "B4GALTs transfer Gal to the keratan chain" +xref: Reactome:R-HSA-2046298 "B4GALTs transfer Gal to a branch of keratan" +xref: Reactome:R-HSA-3656230 "Defective B4GALT1 does not transfer Gal to the keratan chain" +xref: Reactome:R-HSA-4793956 "Defective B4GALT1 does not add Gal to N-glycan" +xref: Reactome:R-HSA-9035949 "Defective B4GALT1 does not transfer Gal to the N-glycan precursor" +xref: Reactome:R-HSA-9035950 "Defective B4GALT1 does not transfer Gal to a branch of keratan" +xref: Reactome:R-HSA-975919 "Addition of galactose by beta 4-galactosyltransferases" +xref: RHEA:22932 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003832 +name: beta-alanyl-dopamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543] +synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] +synonym: "NBAD hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0003833 +name: beta-alanyl amine synthase activity +namespace: molecular_function +def: "Catalysis of the synthesis of beta-alanyl amine conjugate from a precursor biogenic amine, such as dopamine or histamine." [GOC:bf, ISBN:0198506732, PMID:12900414, PMID:12957543, PMID:25229196] +synonym: "beta-alanyl-dopamine synthase activity" RELATED [] +synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] +synonym: "NBAD transferase activity" EXACT [] +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0003834 +name: beta-carotene 15,15'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal." [RHEA:32887] +comment: Formerly EC:1.13.11.n2, EC:1.13.11.21 and then EC 1.14.99.36. +synonym: "beta-carotene 15,15'-monooxygenase activity" RELATED [] +synonym: "carotene 15,15'-dioxygenase activity" RELATED [EC:1.13.11.63] +synonym: "carotene dioxygenase activity" RELATED [EC:1.13.11.63] +xref: EC:1.13.11.63 +xref: KEGG_REACTION:R00032 +xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN +xref: Reactome:R-HSA-975635 "BCMO1:Fe2+ cleaves betaC to atRAL" +xref: RHEA:32887 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0003835 +name: beta-galactoside alpha-2,6-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] +synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] +synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.99.1] +synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.1] +xref: EC:2.4.99.1 +xref: MetaCyc:2.4.99.1-RXN +xref: Reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)" +xref: Reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans" +xref: Reactome:R-HSA-977071 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position" +xref: Reactome:R-HSA-977228 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position" +xref: RHEA:11836 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003836 +name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] +synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" RELATED [EC:2.4.99.4] +synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" RELATED [EC:2.4.99.4] +xref: EC:2.4.99.4 +xref: MetaCyc:2.4.99.4-RXN +xref: Reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans" +xref: Reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH" +xref: Reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid" +xref: Reactome:R-HSA-3656258 "Defective ST3GAL3 does not transfer SA to keratan" +xref: Reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)" +xref: Reactome:R-HSA-9603987 "ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG" +xref: Reactome:R-HSA-9605600 "ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG" +xref: Reactome:R-HSA-981497 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position" +xref: RHEA:21616 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0003837 +name: beta-ureidopropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] +synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" RELATED [EC:3.5.1.6] +xref: EC:3.5.1.6 +xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN +xref: Reactome:R-HSA-73591 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2" +xref: Reactome:R-HSA-73620 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2" +xref: RHEA:11184 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0003838 +name: sterol 24-C-methyltransferase activity +namespace: molecular_function +alt_id: GO:0102101 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [RHEA:21128] +synonym: "24-sterol C-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "delta(24)-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] +synonym: "delta(24)-sterol methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "delta24-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "delta24-sterol methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] +synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" RELATED [EC:2.1.1.41] +synonym: "SMT1 activity" NARROW [EC:2.1.1.41] +synonym: "sterol 24C methyltransferase activity" EXACT [] +synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] +xref: EC:2.1.1.41 +xref: MetaCyc:RXN-11201 +xref: MetaCyc:RXN3O-178 +xref: RHEA:21128 +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0003839 +name: gamma-glutamylcyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354] +synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [] +synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [] +synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [] +synonym: "L-glutamic cyclase activity" EXACT [] +xref: EC:4.3.2.9 +xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN +xref: Reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO" +xref: Reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly" +xref: RHEA:20505 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0003840 +name: obsolete gamma-glutamyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] +comment: This term was obsoleted because it does not correspond to a physiological reaction.\nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity). +synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" RELATED [EC:2.3.2.2] +synonym: "alpha-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2] +synonym: "gamma-glutamyl peptidyltransferase activity" RELATED [EC:2.3.2.2] +synonym: "gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2] +synonym: "gamma-GPT" RELATED [EC:2.3.2.2] +synonym: "gamma-GT" RELATED [EC:2.3.2.2] +synonym: "gamma-GTP" RELATED [EC:2.3.2.2] +synonym: "glutamyl transpeptidase activity" RELATED [EC:2.3.2.2] +synonym: "L-gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.2] +synonym: "L-gamma-glutamyltransferase activity" RELATED [EC:2.3.2.2] +synonym: "L-glutamyltransferase activity" RELATED [EC:2.3.2.2] +xref: EC:2.3.2.2 +xref: KEGG_REACTION:R04159 +xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN +is_obsolete: true +consider: GO:0036374 + +[Term] +id: GO:0003841 +name: 1-acylglycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0004469 +def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] +synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "1-acylglycero-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "1-acylglycerolphosphate acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "1-acylglycerophosphate acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" RELATED [EC:2.3.1.51] +synonym: "lysophosphatidate acyltransferase activity" EXACT [] +synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51] +xref: EC:2.3.1.51 +xref: MetaCyc:RXN-1623 +xref: Reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT" +xref: Reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT" +xref: Reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)" +xref: Reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7" +xref: Reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT" +xref: Reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT" +xref: Reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)" +xref: Reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)" +xref: Reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)" +xref: Reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine" +xref: RHEA:19709 +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity +is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity + +[Term] +id: GO:0003842 +name: 1-pyrroline-5-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.2.1.88] +synonym: "1-pyrroline dehydrogenase" BROAD [] +synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.12] +synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88] +synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" RELATED [] +synonym: "pyrroline-5-carboxylate dehydrogenase activity" RELATED [EC:1.2.1.88] +synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" RELATED [EC:1.2.1.88] +xref: EC:1.2.1.88 +xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN +xref: Reactome:R-HSA-6784399 "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate" +xref: Reactome:R-HSA-70679 "ALDH4A1 oxidises L-GluSS to Glu" +xref: RHEA:16417 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003843 +name: 1,3-beta-D-glucan synthase activity +namespace: molecular_function +alt_id: GO:0009981 +def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34] +synonym: "(1,3)-beta-glucan (callose) synthase activity" RELATED [EC:2.4.1.34] +synonym: "1,3-beta-D-glucan synthetase activity" RELATED [EC:2.4.1.34] +synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "1,3-beta-glucan synthase activity" RELATED [EC:2.4.1.34] +synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "beta-1,3-glucan synthase activity" EXACT [] +synonym: "beta-1,3-glucan synthetase activity" RELATED [EC:2.4.1.34] +synonym: "callose synthase activity" EXACT [] +synonym: "callose synthetase activity" RELATED [EC:2.4.1.34] +synonym: "GS-II" RELATED [EC:2.4.1.34] +synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" RELATED [EC:2.4.1.34] +synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.34] +synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.34] +xref: EC:2.4.1.34 +xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN +xref: RHEA:21476 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003844 +name: 1,4-alpha-glucan branching enzyme activity +namespace: molecular_function +def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] +synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] +synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" RELATED [EC:2.4.1.18] +synonym: "alpha-glucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.18] +synonym: "amylo-(1,4 to 1,6)transglucosidase activity" RELATED [EC:2.4.1.18] +synonym: "amylo-(1,4->1,6)-transglycosylase activity" RELATED [EC:2.4.1.18] +synonym: "amylose isomerase activity" RELATED [EC:2.4.1.18] +synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] +synonym: "branching glycosyltransferase activity" RELATED [EC:2.4.1.18] +synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] +synonym: "enzyme Q" RELATED [EC:2.4.1.18] +synonym: "glucosan transglycosylase activity" RELATED [EC:2.4.1.18] +synonym: "glycogen branching enzyme activity" RELATED [EC:2.4.1.18] +synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] +synonym: "Q-enzyme" RELATED [EC:2.4.1.18] +synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] +xref: EC:2.4.1.18 +xref: MetaCyc:GLYCOGEN-BRANCH-RXN +xref: Reactome:R-HSA-3322005 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a" +xref: Reactome:R-HSA-3322016 "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a" +xref: Reactome:R-HSA-3322057 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" +xref: Reactome:R-HSA-3878762 "Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)" +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0003845 +name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity +namespace: molecular_function +def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [PMID:15761036] +subset: gocheck_do_not_annotate +synonym: "11beta-hydroxy steroid dehydrogenase" RELATED [] +synonym: "11beta-hydroxysteroid dehydrogenase" RELATED [] +synonym: "beta-hydroxysteroid dehydrogenase" BROAD [] +synonym: "corticosteroid 11-reductase" RELATED [] +synonym: "corticosteroid 11beta-dehydrogenase" RELATED [] +xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-194023 "HSD11B2,HSD11B1 dimer oxidise CORT to COR" +xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003846 +name: 2-acylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [PMID:4016575] +synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" RELATED [EC:2.3.1.22] +synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.22] +synonym: "acylglycerol palmitoyltransferase activity" RELATED [EC:2.3.1.22] +synonym: "monoacylglycerol acyltransferase activity" RELATED [EC:2.3.1.22] +synonym: "monoglyceride acyltransferase activity" RELATED [EC:2.3.1.22] +xref: EC:2.3.1.22 +xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG" +xref: Reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG" +xref: RHEA:16741 +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0003847 +name: 1-alkyl-2-acetylglycerophosphocholine esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] +subset: goslim_chembl +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" RELATED [EC:3.1.1.47] +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] +synonym: "alkylacetyl-GPC:acetylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] +synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] +synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] +synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] +synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] +synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] +xref: EC:3.1.1.47 +xref: MetaCyc:3.1.1.47-RXN +xref: Reactome:R-HSA-8869206 "PAFAH2 hydrolyses PAF to lyso-PAF and acetate" +xref: RHEA:17777 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0003848 +name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11412] +subset: goslim_chembl +synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] +synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" RELATED [EC:2.7.6.3] +synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" RELATED [EC:2.7.6.3] +synonym: "HPPK" RELATED [EC:2.7.6.3] +synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" RELATED [EC:2.7.6.3] +xref: EC:2.7.6.3 +xref: KEGG_REACTION:R03503 +xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN +xref: RHEA:11412 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0003849 +name: 3-deoxy-7-phosphoheptulonate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14717] +comment: Note that this function was formerly EC:4.1.2.15. +synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" RELATED [EC:2.5.1.54] +synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" RELATED [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" RELATED [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" RELATED [EC:2.5.1.54] +synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" RELATED [EC:2.5.1.54] +synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] +synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54] +synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54] +synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.54] +synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] +synonym: "DAH7-P synthase activity" RELATED [EC:2.5.1.54] +synonym: "DAHP synthase activity" RELATED [EC:2.5.1.54] +synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" RELATED [EC:2.5.1.54] +synonym: "DHAP synthase activity" RELATED [EC:2.5.1.54] +synonym: "DS-Co activity" RELATED [EC:2.5.1.54] +synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] +synonym: "KDPH synthase activity" RELATED [EC:2.5.1.54] +synonym: "KDPH synthetase activity" RELATED [EC:2.5.1.54] +synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" RELATED [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54] +synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" RELATED [EC:2.5.1.54] +synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" RELATED [EC:2.5.1.54] +synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.54] +xref: EC:2.5.1.54 +xref: KEGG_REACTION:R01826 +xref: MetaCyc:DAHPSYN-RXN +xref: RHEA:14717 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003850 +name: 2-deoxyglucose-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] +synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.68] +synonym: "2-deoxyglucose-6-phosphate phosphatase activity" RELATED [EC:3.1.3.68] +xref: EC:3.1.3.68 +xref: KEGG_REACTION:R02587 +xref: MetaCyc:3.1.3.68-RXN +xref: RHEA:22236 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0003851 +name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] +synonym: "cerebroside synthase activity" RELATED [EC:2.4.1.45] +synonym: "UDP-galactose-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.45] +synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" RELATED [EC:2.4.1.45] +synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" RELATED [EC:2.4.1.45] +synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" RELATED [EC:2.4.1.45] +synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" RELATED [EC:2.4.1.45] +synonym: "UDPgalactose:ceramide galactosyltransferase activity" RELATED [EC:2.4.1.45] +synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" RELATED [EC:2.4.1.45] +xref: EC:2.4.1.47 +xref: MetaCyc:2.4.1.45-RXN +xref: RHEA:10856 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003852 +name: 2-isopropylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21524] +comment: Note that this function was formerly EC:4.1.3.12. +synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.13] +synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.13] +synonym: "alpha-IPM synthetase activity" RELATED [EC:2.3.3.13] +synonym: "alpha-isopropylmalate synthase activity" RELATED [EC:2.3.3.13] +synonym: "alpha-isopropylmalate synthetase activity" RELATED [EC:2.3.3.13] +synonym: "alpha-isopropylmalic synthetase activity" RELATED [EC:2.3.3.13] +synonym: "isopropylmalate synthase activity" RELATED [EC:2.3.3.13] +synonym: "isopropylmalate synthetase activity" RELATED [EC:2.3.3.13] +xref: EC:2.3.3.13 +xref: KEGG_REACTION:R01213 +xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN +xref: RHEA:21524 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0003853 +name: 2-methylacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] +synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] +synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" RELATED [EC:1.3.99.12] +synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.3.99.12] +synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] +xref: EC:1.3.99.12 +xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN +xref: RHEA:13261 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0003854 +name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145] +synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] +synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.145] +synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.145] +synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] +synonym: "steroid-delta5-3beta-ol dehydrogenase activity" RELATED [EC:1.1.1.145] +xref: EC:1.1.1.145 +xref: MetaCyc:1.1.1.145-RXN +xref: Reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one" +xref: Reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one" +xref: Reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one" +xref: Reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione" +xref: Reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol" +xref: RHEA:24076 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003855 +name: 3-dehydroquinate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21096] +synonym: "3-dehydroquinase activity" RELATED [EC:4.2.1.10] +synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" RELATED [EC:4.2.1.10] +synonym: "3-dehydroquinate hydro-lyase activity" RELATED [EC:4.2.1.10] +synonym: "3-dehydroquinate hydrolase activity" RELATED [EC:4.2.1.10] +synonym: "5-dehydroquinase activity" RELATED [EC:4.2.1.10] +synonym: "5-dehydroquinate dehydratase activity" RELATED [EC:4.2.1.10] +synonym: "5-dehydroquinate hydro-lyase activity" RELATED [EC:4.2.1.10] +synonym: "dehydroquinase activity" RELATED [EC:4.2.1.10] +synonym: "dehydroquinate dehydratase activity" RELATED [EC:4.2.1.10] +synonym: "DHQase" RELATED [EC:4.2.1.10] +xref: EC:4.2.1.10 +xref: KEGG_REACTION:R03084 +xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN +xref: RHEA:21096 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003856 +name: 3-dehydroquinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21968] +xref: EC:4.2.3.4 +xref: KEGG_REACTION:R03083 +xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN +xref: RHEA:21968 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0003857 +name: 3-hydroxyacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] +comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. +synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079] +synonym: "beta-hydroxyacyl dehydrogenase activity" RELATED [EC:1.1.1.35] +synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" RELATED [EC:1.1.1.35] +synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" RELATED [EC:1.1.1.35] +synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35] +synonym: "beta-keto-reductase activity" RELATED [EC:1.1.1.35] +synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] +synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" RELATED [EC:1.1.1.35] +synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.35] +xref: EC:1.1.1.35 +xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN +xref: Reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA" +xref: Reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA" +xref: Reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+" +xref: Reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA" +xref: Reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+" +xref: Reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA" +xref: Reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+" +xref: Reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H" +xref: Reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H" +xref: Reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H" +xref: Reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H" +xref: Reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H" +xref: Reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H" +xref: Reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H" +xref: RHEA:22432 +xref: UM-BBD_enzymeID:e0664 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003858 +name: 3-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20521] +synonym: "D-beta-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.30] +xref: EC:1.1.1.30 +xref: KEGG_REACTION:R01361 +xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-5696457 "BDH2 dehydrogenates 3HBA" +xref: Reactome:R-HSA-73912 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+" +xref: Reactome:R-HSA-73920 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+" +xref: RHEA:20521 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003859 +name: 3-hydroxybutyryl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17849] +synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" RELATED [EC:4.2.1.55] +synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.55] +synonym: "crotonase activity" RELATED [EC:4.2.1.55] +synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" RELATED [EC:4.2.1.55] +synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" RELATED [EC:4.2.1.55] +synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] +xref: EC:4.2.1.55 +xref: KEGG_REACTION:R03027 +xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN +xref: RHEA:17849 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003860 +name: 3-hydroxyisobutyryl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] +synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" RELATED [EC:3.1.2.4] +synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" RELATED [EC:3.1.2.4] +synonym: "HIB CoA deacylase activity" RELATED [EC:3.1.2.4] +xref: EC:3.1.2.4 +xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN +xref: Reactome:R-HSA-70881 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA" +xref: RHEA:20888 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0003861 +name: 3-isopropylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate." [EC:4.2.1.33] +synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" RELATED [EC:4.2.1.33] +synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" RELATED [EC:4.2.1.33] +synonym: "alpha-IPM isomerase activity" RELATED [EC:4.2.1.33] +synonym: "alpha-isopropylmalate isomerase activity" RELATED [EC:4.2.1.33] +synonym: "beta-isopropylmalate dehydratase activity" RELATED [EC:4.2.1.33] +synonym: "isopropylmalate isomerase activity" RELATED [EC:4.2.1.33] +xref: EC:4.2.1.33 +xref: MetaCyc:3-ISOPROPYLMALISOM-RXN +xref: RHEA:32287 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003862 +name: 3-isopropylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85, RHEA:32271] +synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.85] +synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.85] +synonym: "beta-IPM dehydrogenase activity" RELATED [EC:1.1.1.85] +synonym: "beta-isopropylmalate dehydrogenase activity" RELATED [EC:1.1.1.85] +synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] +synonym: "IMDH activity" RELATED [EC:1.1.1.85] +synonym: "IPMDH" RELATED [EC:1.1.1.85] +synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" RELATED [EC:1.1.1.85] +xref: EC:1.1.1.85 +xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN +xref: RHEA:32271 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003863 +name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity +namespace: molecular_function +alt_id: GO:0003826 +def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] +synonym: "2-oxoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" RELATED [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" RELATED [EC:1.2.4.4] +synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" RELATED [EC:1.2.4.4] +synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "alpha-ketoacid dehydrogenase activity" NARROW [] +synonym: "alpha-ketoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "alpha-ketoisocaproic dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "alpha-ketoisovalerate dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "alpha-oxoisocaproate dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "BCKDH activity" RELATED [EC:1.2.4.4] +synonym: "BCOAD activity" RELATED [EC:1.2.4.4] +synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] +synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" RELATED [EC:1.2.4.4] +synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] +xref: EC:1.2.4.4 +xref: MetaCyc:1.2.4.4-RXN +xref: RHEA:13457 +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0003864 +name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] +synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +synonym: "dehydropantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +synonym: "ketopantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +synonym: "oxopantoate hydroxymethyltransferase activity" RELATED [EC:2.1.2.11] +xref: EC:2.1.2.11 +xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN +xref: RHEA:11824 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0003865 +name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] +synonym: "3-keto-delta4-steroid-5alpha-reductase activity" RELATED [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" RELATED [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" RELATED [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" RELATED [EC:1.3.99.5] +synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" RELATED [EC:1.3.99.5] +synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] +synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" RELATED [EC:1.3.99.5] +synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "delta4-3-keto steroid 5alpha-reductase activity" RELATED [EC:1.3.99.5] +synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" RELATED [EC:1.3.99.5] +synonym: "delta4-3-oxo steroid reductase activity" RELATED [EC:1.3.99.5] +synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "delta4-5alpha-dehydrogenase activity" RELATED [EC:1.3.99.5] +synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] +synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] +synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] +synonym: "steroid delta4-5alpha-reductase activity" RELATED [EC:1.3.99.5] +synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] +xref: EC:1.3.99.5 +xref: MetaCyc:1.3.99.5-RXN +xref: Reactome:R-HSA-469659 "SRD5A1 dehydrogenates TEST to DHTEST" +xref: Reactome:R-HSA-9705713 "SRD5A2 dehydrogenates TEST to DHTEST" +xref: Reactome:R-HSA-9705714 "SRD5A3 dehydrogenates TEST to DHTEST" +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0003866 +name: 3-phosphoshikimate 1-carboxyvinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21256] +synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" RELATED [EC:2.5.1.19] +synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" RELATED [EC:2.5.1.19] +synonym: "EPSP synthase activity" RELATED [EC:2.5.1.19] +synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" RELATED [EC:2.5.1.19] +xref: EC:2.5.1.19 +xref: KEGG_REACTION:R03460 +xref: MetaCyc:2.5.1.19-RXN +xref: RHEA:21256 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003867 +name: 4-aminobutyrate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [GOC:mah] +synonym: "4-aminobutanoate transaminase activity" EXACT [] +synonym: "4-aminobutyrate aminotransferase activity" EXACT [] +synonym: "4-aminobutyric acid aminotransferase activity" EXACT [] +synonym: "aminobutyrate aminotransferase activity" EXACT [] +synonym: "aminobutyrate transaminase activity" EXACT [] +synonym: "beta-alanine aminotransferase" RELATED [] +synonym: "GABA aminotransferase activity" EXACT [] +synonym: "GABA transaminase activity" EXACT [] +synonym: "GABA transferase activity" EXACT [] +synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [] +synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [] +synonym: "gamma-aminobutyrate transaminase activity" EXACT [] +synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [] +synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] +synonym: "gamma-aminobutyric transaminase activity" EXACT [] +synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [] +xref: MetaCyc:GABATRANSAM-RXN +xref: Reactome:R-HSA-916855 "PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA" +xref: RHEA:23352 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0003868 +name: 4-hydroxyphenylpyruvate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] +synonym: "4-hydroxyphenylpyruvate hydroxylase activity" RELATED [EC:1.13.11.27] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" RELATED [EC:1.13.11.27] +synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate dioxygenase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate hydroxylase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvate oxidase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic hydroxylase activity" RELATED [EC:1.13.11.27] +synonym: "p-hydroxyphenylpyruvic oxidase activity" RELATED [EC:1.13.11.27] +xref: EC:1.13.11.27 +xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN +xref: Reactome:R-HSA-71163 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2" +xref: RHEA:16189 +xref: UM-BBD_reactionID:r0298 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0003870 +name: 5-aminolevulinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12921] +synonym: "5-aminolevulinate synthetase activity" RELATED [EC:2.3.1.37] +synonym: "5-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37] +synonym: "5-aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37] +synonym: "ALA synthase activity" RELATED [EC:2.3.1.37] +synonym: "ALA synthetase activity" RELATED [EC:2.3.1.37] +synonym: "ALAS activity" RELATED [EC:2.3.1.37] +synonym: "alpha-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37] +synonym: "aminolevulinate synthase activity" RELATED [EC:2.3.1.37] +synonym: "aminolevulinate synthetase activity" RELATED [EC:2.3.1.37] +synonym: "aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37] +synonym: "aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37] +synonym: "aminolevulinic synthetase activity" RELATED [EC:2.3.1.37] +synonym: "delta-ALA synthetase activity" RELATED [EC:2.3.1.37] +synonym: "delta-aminolevulinate synthase activity" RELATED [EC:2.3.1.37] +synonym: "delta-aminolevulinate synthetase activity" RELATED [EC:2.3.1.37] +synonym: "delta-aminolevulinic acid synthase activity" RELATED [EC:2.3.1.37] +synonym: "delta-aminolevulinic acid synthetase activity" RELATED [EC:2.3.1.37] +synonym: "delta-aminolevulinic synthetase activity" RELATED [EC:2.3.1.37] +synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" RELATED [EC:2.3.1.37] +xref: EC:2.3.1.37 +xref: KEGG_REACTION:R00830 +xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN +xref: Reactome:R-HSA-189442 "ALAS condenses SUCC-CoA and Gly to form dALA" +xref: RHEA:12921 +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0003871 +name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21196] +synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.14] +synonym: "cobalamin-independent methionine synthase activity" RELATED [EC:2.1.1.14] +synonym: "homocysteine methylase activity" RELATED [EC:2.1.1.14] +synonym: "MetE" RELATED [EC:2.1.1.14] +synonym: "methionine synthase (cobalamin-independent) activity" RELATED [EC:2.1.1.14] +synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" RELATED [EC:2.1.1.14] +synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" RELATED [EC:2.1.1.14] +synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" RELATED [EC:2.1.1.14] +synonym: "tetrahydropteroyltriglutamate methyltransferase activity" RELATED [EC:2.1.1.14] +xref: EC:2.1.1.14 +xref: KEGG_REACTION:R04405 +xref: MetaCyc:HOMOCYSMET-RXN +xref: RHEA:21196 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity + +[Term] +id: GO:0003872 +name: 6-phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] +synonym: "6-phosphofructokinase reduction" EXACT [] +synonym: "6-phosphofructose 1-kinase activity" RELATED [EC:2.7.1.11] +synonym: "ATP-dependent phosphofructokinase activity" RELATED [EC:2.7.1.11] +synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.11] +synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.11] +synonym: "fructose 6-phosphate kinase activity" RELATED [EC:2.7.1.11] +synonym: "fructose 6-phosphokinase activity" RELATED [EC:2.7.1.11] +synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" RELATED [EC:2.7.1.11] +synonym: "PFK" RELATED [EC:2.7.1.11] +synonym: "phospho-1,6-fructokinase activity" RELATED [EC:2.7.1.11] +synonym: "phosphofructokinase (phosphorylating)" RELATED [EC:2.7.1.11] +synonym: "phosphofructokinase I activity" RELATED [EC:2.7.1.11] +synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] +xref: EC:2.7.1.11 +xref: MetaCyc:6PFRUCTPHOS-RXN +xref: Reactome:R-HSA-70467 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP" +xref: RHEA:16109 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0003873 +name: 6-phosphofructo-2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15653] +synonym: "6-phosphofructo-2-kinase (phosphorylating)" RELATED [EC:2.7.1.105] +synonym: "6-phosphofructose 2-kinase activity" RELATED [EC:2.7.1.105] +synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" RELATED [EC:2.7.1.105] +synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" RELATED [EC:2.7.1.105] +synonym: "fructose 6-phosphate 2-kinase activity" RELATED [EC:2.7.1.105] +synonym: "phosphofructokinase 2 activity" RELATED [EC:2.7.1.105] +xref: EC:2.7.1.105 +xref: KEGG_REACTION:R02732 +xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN +xref: Reactome:R-HSA-71802 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP" +xref: RHEA:15653 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0003874 +name: 6-pyruvoyltetrahydropterin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22048] +synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" RELATED [EC:4.2.3.12] +synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" RELATED [EC:4.2.3.12] +synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" RELATED [EC:4.2.3.12] +synonym: "PTPS activity" RELATED [EC:4.2.3.12] +xref: EC:4.2.3.12 +xref: KEGG_REACTION:R04286 +xref: MetaCyc:4.2.3.12-RXN +xref: Reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP" +xref: RHEA:22048 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0003875 +name: ADP-ribosylarginine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] +synonym: "ADP-ribose-L-arginine cleavage enzyme activity" RELATED [EC:3.2.2.19] +synonym: "ADP-ribose-L-arginine cleaving enzyme activity" RELATED [EC:3.2.2.19] +synonym: "ADPribosylarginine hydrolase activity" EXACT [] +synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] +synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] +synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] +synonym: "protein ADP-ribosylarginine hydrolase activity" RELATED [EC:3.2.2.19] +synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.19] +xref: EC:3.2.2.19 +xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN +xref: RHEA:20784 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0003876 +name: AMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] +synonym: "5-adenylate deaminase activity" RELATED [EC:3.5.4.6] +synonym: "5-adenylic acid deaminase activity" RELATED [EC:3.5.4.6] +synonym: "5-AMP deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenosine 5-monophosphate deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenosine 5-phosphate aminohydrolase activity" RELATED [EC:3.5.4.6] +synonym: "adenosine monophosphate deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenyl deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenylate aminohydrolase activity" RELATED [EC:3.5.4.6] +synonym: "adenylate deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenylate deaminase reaction" EXACT [] +synonym: "adenylate desaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenylic acid deaminase activity" RELATED [EC:3.5.4.6] +synonym: "adenylic deaminase activity" RELATED [EC:3.5.4.6] +synonym: "AMP aminase activity" RELATED [EC:3.5.4.6] +synonym: "AMP aminohydrolase activity" RELATED [EC:3.5.4.6] +synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] +xref: EC:3.5.4.6 +xref: MetaCyc:AMP-DEAMINASE-RXN +xref: Reactome:R-HSA-76590 "AMP + H2O => IMP + NH4+ (AMPD)" +xref: RHEA:14777 +is_a: GO:0047623 ! adenosine-phosphate deaminase activity + +[Term] +id: GO:0003877 +name: ATP adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] +synonym: "adenine triphosphate adenylyltransferase activity" RELATED [EC:2.7.7.53] +synonym: "ADP:ATP adenylyltransferase activity" EXACT [] +synonym: "AP-4-A phosphorylase activity" RELATED [EC:2.7.7.53] +synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" RELATED [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" RELATED [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" RELATED [EC:2.7.7.53] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" RELATED [EC:2.7.7.53] +synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" RELATED [EC:2.7.7.53] +synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" RELATED [EC:2.7.7.53] +synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" RELATED [EC:2.7.7.53] +xref: EC:2.7.7.53 +xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN +xref: RHEA:16577 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0003878 +name: ATP citrate synthase activity +namespace: molecular_function +alt_id: GO:0046913 +def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [RHEA:21160] +comment: Note that this function was formerly EC:4.1.3.8. Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" RELATED [EC:2.3.3.8] +synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" RELATED [EC:2.3.3.8] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] +synonym: "adenosine triphosphate citrate lyase activity" RELATED [EC:2.3.3.8] +synonym: "ATP citrate (pro-S)-lyase activity" RELATED [EC:2.3.3.8] +synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] +synonym: "ATP-citrate (pro-S-)-lyase activity" RELATED [EC:2.3.3.8] +synonym: "ATP-citric lyase activity" RELATED [EC:2.3.3.8] +synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" RELATED [EC:2.3.3.8] +synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] +synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] +synonym: "citrate-ATP lyase activity" RELATED [EC:2.3.3.8] +synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] +xref: EC:2.3.3.8 +xref: KEGG_REACTION:R00352 +xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN +xref: MetaCyc:PWY-5172 +xref: Reactome:R-HSA-75848 "ACLY tetramer transforms CIT to Ac-CoA" +xref: RHEA:21160 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0003879 +name: ATP phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] +synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.17] +synonym: "adenosine triphosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyl ATP synthetase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP diphosphorylase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP pyrophosphorylase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate synthetase activity" RELATED [EC:2.4.2.17] +synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.17] +xref: EC:2.4.2.17 +xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN +xref: RHEA:18473 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0003880 +name: protein C-terminal carboxyl O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] +synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] +is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity + +[Term] +id: GO:0003881 +name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11580] +synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-DG:inositol transferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-diglyceride-inositol transferase activity" RELATED [EC:2.7.8.11] +synonym: "CDP-diglyceride:inositol transferase activity" RELATED [EC:2.7.8.11] +synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" RELATED [EC:2.7.8.11] +synonym: "cytidine diphosphoglyceride-inositol transferase activity" RELATED [EC:2.7.8.11] +synonym: "phosphatidylinositol synthase activity" EXACT [] +xref: EC:2.7.8.11 +xref: KEGG_REACTION:R01802 +xref: MetaCyc:2.7.8.11-RXN +xref: Reactome:R-HSA-1482976 "CDP-DAG is converted to PI by CDIPT" +xref: RHEA:11580 +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0003882 +name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] +synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" RELATED [EC:2.7.8.8] +synonym: "phosphatidylserine synthase activity" RELATED [EC:2.7.8.8] +synonym: "phosphatidylserine synthetase activity" RELATED [EC:2.7.8.8] +synonym: "PS synthase activity" RELATED [EC:2.7.8.8] +synonym: "serine exchange enzyme" BROAD [] +xref: EC:2.7.8.8 +xref: MetaCyc:PHOSPHASERSYN-RXN +xref: RHEA:16913 +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0003883 +name: CTP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] +synonym: "CTP synthetase activity" RELATED [EC:6.3.4.2] +synonym: "cytidine 5'-triphosphate synthetase activity" RELATED [EC:6.3.4.2] +synonym: "cytidine triphosphate synthetase activity" RELATED [EC:6.3.4.2] +synonym: "uridine triphosphate aminase activity" RELATED [EC:6.3.4.2] +synonym: "UTP--ammonia ligase activity" RELATED [EC:6.3.4.2] +synonym: "UTP:ammonia ligase (ADP-forming)" RELATED [EC:6.3.4.2] +xref: EC:6.3.4.2 +xref: MetaCyc:CTPSYN-RXN +xref: Reactome:R-HSA-504054 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]" +xref: Reactome:R-HSA-73647 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]" +xref: RHEA:16597 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0003884 +name: D-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] +synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.3] +synonym: "L-amino acid:O2 oxidoreductase activity" RELATED [EC:1.4.3.3] +synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] +xref: EC:1.4.3.3 +xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN +xref: Reactome:R-HSA-389821 "glycine + O2 => glyoxylate + H2O2 + NH4+" +xref: RHEA:21816 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0003885 +name: D-arabinono-1,4-lactone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23756] +synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" RELATED [EC:1.1.3.37] +xref: EC:1.1.3.37 +xref: KEGG_REACTION:R02715 +xref: MetaCyc:1.1.3.37-RXN +xref: RHEA:23756 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0003886 +name: DNA (cytosine-5-)-methyltransferase activity +namespace: molecular_function +alt_id: GO:0008326 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] +comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). +synonym: "cytosine 5-methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] +synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] +synonym: "cytosine-specific DNA methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] +synonym: "DNA 5-cytosine methylase activity" RELATED [EC:2.1.1.37] +synonym: "DNA cytosine C(5) methylase activity" RELATED [EC:2.1.1.37] +synonym: "DNA cytosine C5 methylase activity" RELATED [EC:2.1.1.37] +synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] +synonym: "DNA-cytosine 5-methylase activity" RELATED [EC:2.1.1.37] +synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] +synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "modification methylase activity" RELATED [EC:2.1.1.37] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] +synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.37] +synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] +synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] +xref: EC:2.1.1.37 +xref: MetaCyc:2.1.1.73-RXN +xref: RHEA:13681 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0003887 +name: DNA-directed DNA polymerase activity +namespace: molecular_function +alt_id: GO:0003888 +alt_id: GO:0003889 +alt_id: GO:0003890 +alt_id: GO:0003891 +alt_id: GO:0003893 +alt_id: GO:0003894 +alt_id: GO:0003895 +alt_id: GO:0008723 +alt_id: GO:0015999 +alt_id: GO:0016000 +alt_id: GO:0016448 +alt_id: GO:0016449 +alt_id: GO:0016450 +alt_id: GO:0016451 +alt_id: GO:0016452 +alt_id: GO:0019984 +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] +synonym: "alpha DNA polymerase activity" NARROW [] +synonym: "beta DNA polymerase activity" NARROW [] +synonym: "delta DNA polymerase activity" NARROW [] +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleic acid duplicase activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleic duplicase activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] +synonym: "DNA duplicase activity" RELATED [EC:2.7.7.7] +synonym: "DNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.7] +synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] +synonym: "DNA polymerase V activity" NARROW [] +synonym: "DNA replicase activity" RELATED [EC:2.7.7.7] +synonym: "DNA-dependent DNA polymerase activity" RELATED [EC:2.7.7.7] +synonym: "duplicase" BROAD [EC:2.7.7.7] +synonym: "epsilon DNA polymerase activity" NARROW [] +synonym: "eta DNA polymerase activity" NARROW [] +synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] +synonym: "iota DNA polymerase activity" NARROW [] +synonym: "kappa DNA polymerase activity" NARROW [] +synonym: "Klenow fragment" NARROW [EC:2.7.7.7] +synonym: "lambda DNA polymerase activity" NARROW [] +synonym: "mu DNA polymerase activity" NARROW [] +synonym: "nu DNA polymerase activity" NARROW [] +synonym: "sequenase" RELATED [EC:2.7.7.7] +synonym: "sigma DNA polymerase activity" NARROW [] +synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] +synonym: "Taq Pol I" NARROW [EC:2.7.7.7] +synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] +synonym: "theta DNA polymerase activity" NARROW [] +synonym: "zeta DNA polymerase activity" NARROW [] +xref: EC:2.7.7.7 +xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN +xref: Reactome:R-HSA-110311 "POLZ extends translesion synthesis" +xref: Reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH" +xref: Reactome:R-HSA-110319 "Elongation by POLH" +xref: Reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis" +xref: Reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site" +xref: Reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand" +xref: Reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis" +xref: Reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" +xref: Reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments" +xref: Reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap" +xref: Reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution" +xref: Reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis" +xref: Reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS" +xref: Reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base" +xref: Reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini" +xref: Reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base" +xref: Reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP" +xref: Reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps" +xref: Reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ" +xref: Reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER" +xref: Reactome:R-HSA-5693593 "D-loop extension by DNA polymerases" +xref: Reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER" +xref: Reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN" +xref: Reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin" +xref: Reactome:R-HSA-69116 "Formation of Okazaki fragments" +xref: Reactome:R-HSA-73932 "Resynthesis of excised residue by POLB" +is_a: GO:0034061 ! DNA polymerase activity + +[Term] +id: GO:0003892 +name: obsolete proliferating cell nuclear antigen +namespace: molecular_function +alt_id: GO:0005661 +def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] +comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "PCNA" EXACT [] +synonym: "proliferating cell nuclear antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003896 +name: DNA primase activity +namespace: molecular_function +alt_id: GO:0003897 +alt_id: GO:0003898 +def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] +xref: EC:2.7.7.101 +is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:0003899 +name: DNA-directed 5'-3' RNA polymerase activity +namespace: molecular_function +alt_id: GO:0000129 +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf] +synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] +synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] +synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6] +synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6] +synonym: "DNA-dependent RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6] +synonym: "DNA-dependent RNA polymerase activity" RELATED [EC:2.7.7.6] +synonym: "DNA-directed RNA polymerase activity" BROAD [] +synonym: "DNA-directed RNA polymerase I activity" NARROW [] +synonym: "DNA-directed RNA polymerase II activity" NARROW [] +synonym: "DNA-directed RNA polymerase III activity" NARROW [] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6] +synonym: "RNA nucleotidyltransferase (DNA-directed) activity" RELATED [EC:2.7.7.6] +synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] +synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] +synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] +synonym: "transcriptase" BROAD [EC:2.7.7.6] +xref: EC:2.7.7.6 +xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN +xref: Reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30" +xref: Reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition" +xref: Reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript" +xref: Reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition" +xref: Reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript" +xref: Reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript" +xref: Reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" +xref: Reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes" +xref: Reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene" +xref: Reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript" +xref: Reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template" +xref: Reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin" +xref: Reactome:R-HSA-74986 "Elongation of pre-rRNA transcript" +xref: Reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript" +xref: Reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition" +xref: Reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript" +xref: Reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition" +xref: Reactome:R-HSA-9670149 "TERRA transcription" +xref: Reactome:R-HSA-9697084 "Defective rpoB in Mtb RNAP transcribes RNA polyanion" +xref: Reactome:R-HSA-9697085 "RNAP transcribes Mtb RNA polyanion" +is_a: GO:0034062 ! 5'-3' RNA polymerase activity + +[Term] +id: GO:0003900 +name: obsolete DNA-directed RNA polymerase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. +synonym: "DNA-directed RNA polymerase I activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003901 +name: obsolete DNA-directed RNA polymerase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. +synonym: "DNA-directed RNA polymerase II activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003902 +name: obsolete DNA-directed RNA polymerase III activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] +comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. +synonym: "DNA-directed RNA polymerase III activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003899 + +[Term] +id: GO:0003904 +name: deoxyribodipyrimidine photo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3] +synonym: "CPD photolyase activity" EXACT [PMID:16302973] +synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" RELATED [EC:4.1.99.3] +synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] +synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" RELATED [EC:4.1.99.3] +synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" RELATED [EC:4.1.99.3] +synonym: "deoxyribonucleic photolyase activity" RELATED [EC:4.1.99.3] +synonym: "dipyrimidine photolyase (photosensitive)" RELATED [EC:4.1.99.3] +synonym: "DNA cyclobutane dipyrimidine photolyase activity" RELATED [EC:4.1.99.3] +synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] +synonym: "photolyase activity" RELATED [EC:4.1.99.3] +synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] +synonym: "phr A photolyase activity" RELATED [EC:4.1.99.3] +synonym: "PhrB photolyase activity" RELATED [EC:4.1.99.3] +synonym: "PRE" RELATED [EC:4.1.99.3] +xref: EC:4.1.99.3 +xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN +xref: RHEA:10672 +is_a: GO:0003913 ! DNA photolyase activity + +[Term] +id: GO:0003905 +name: alkylbase DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0004036 +def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] +synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] +synonym: "AlkA" RELATED [EC:3.2.2.21] +synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] +synonym: "alkylbase DNA glycosidase activity" EXACT [] +synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] +synonym: "DNA glycosidase II activity" RELATED [EC:3.2.2.21] +synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] +synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0003906 +name: DNA-(apurinic or apyrimidinic site) endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease] +comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV. +synonym: "abasic deoxyendoribonuclease activity" EXACT [] +synonym: "AP deoxyendoribonuclease activity" EXACT [] +synonym: "apurinic deoxyendoribonuclease activity" EXACT [] +synonym: "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT [] +synonym: "apyrimidinic deoxyendoribonuclease activity" EXACT [] +synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [] +synonym: "endonuclease VIII activity" RELATED [] +synonym: "UV endonuclease" BROAD [] +xref: Reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break" +xref: Reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site" +xref: Reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)" +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0003908 +name: methylated-DNA-[protein]-cysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] +synonym: "6-O-methylguanine-DNA methyltransferase activity" RELATED [EC:2.1.1.63] +synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] +synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" RELATED [EC:2.1.1.63] +synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" RELATED [EC:2.1.1.63] +synonym: "MGMT" EXACT [] +synonym: "O-6-methylguanine-DNA-alkyltransferase activity" RELATED [EC:2.1.1.63] +synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] +xref: EC:2.1.1.63 +xref: MetaCyc:2.1.1.63-RXN +xref: Reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal" +xref: RHEA:24000 +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0003909 +name: DNA ligase activity +namespace: molecular_function +def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094] +xref: Reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand" +xref: Reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA" +xref: Reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA" +xref: Reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break" +xref: Reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB" +xref: Reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB" +xref: Reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ" +xref: Reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER" +xref: Reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ" +xref: Reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER" +xref: Reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments" +xref: Reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway" +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0003910 +name: DNA ligase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] +synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] +synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] +synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] +synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] +synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] +synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" RELATED [EC:6.5.1.1] +synonym: "polydeoxyribonucleotide synthase (ATP) activity" RELATED [EC:6.5.1.1] +synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] +synonym: "polynucleotide ligase (ATP) activity" RELATED [EC:6.5.1.1] +synonym: "sealase activity" RELATED [EC:6.5.1.1] +xref: EC:6.5.1.1 +xref: MetaCyc:DNA-LIGASE-ATP-RXN +is_a: GO:0003909 ! DNA ligase activity + +[Term] +id: GO:0003911 +name: DNA ligase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] +synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] +synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] +synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] +synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] +synonym: "DNA ligase (NAD)" RELATED [EC:6.5.1.2] +synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] +synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] +synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" RELATED [EC:6.5.1.2] +synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" RELATED [EC:6.5.1.2] +synonym: "polydeoxyribonucleotide synthase (NAD)" RELATED [EC:6.5.1.2] +synonym: "polydeoxyribonucleotide synthase (NAD+) activity" RELATED [EC:6.5.1.2] +synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD(+)) activity" RELATED [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD)" RELATED [EC:6.5.1.2] +synonym: "polynucleotide ligase (NAD+) activity" RELATED [EC:6.5.1.2] +synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" RELATED [EC:6.5.1.2] +synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" RELATED [EC:6.5.1.2] +synonym: "polynucleotide synthetase activity" RELATED [EC:6.5.1.2] +xref: EC:6.5.1.2 +xref: MetaCyc:DNA-LIGASE-NAD+-RXN +is_a: GO:0003909 ! DNA ligase activity + +[Term] +id: GO:0003912 +name: DNA nucleotidylexotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] +synonym: "addase activity" RELATED [EC:2.7.7.31] +synonym: "deoxynucleotidyl terminal transferase activity" RELATED [EC:2.7.7.31] +synonym: "deoxyribonucleic acid nucleotidyltransferase activity" RELATED [EC:2.7.7.31] +synonym: "deoxyribonucleic nucleotidyltransferase activity" RELATED [EC:2.7.7.31] +synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" RELATED [EC:2.7.7.31] +synonym: "TdT" RELATED [EC:2.7.7.31] +synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] +synonym: "terminal deoxynucleotide transferase activity" RELATED [EC:2.7.7.31] +synonym: "terminal deoxynucleotidyltransferase activity" RELATED [EC:2.7.7.31] +synonym: "terminal deoxyribonucleotidyltransferase activity" RELATED [EC:2.7.7.31] +synonym: "terminal transferase activity" RELATED [EC:2.7.7.31] +xref: EC:2.7.7.31 +xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0003913 +name: DNA photolyase activity +namespace: molecular_function +def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] +xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN +is_a: GO:0016830 ! carbon-carbon lyase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0003914 +name: DNA (6-4) photolyase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] +xref: EC:4.1.99.13 +xref: MetaCyc:RXN-10771 +is_a: GO:0003913 ! DNA photolyase activity + +[Term] +id: GO:0003916 +name: DNA topoisomerase activity +namespace: molecular_function +alt_id: GO:0009387 +def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] +xref: EC:5.6.2.- +is_a: GO:0016853 ! isomerase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0003917 +name: DNA topoisomerase type I (single strand cut, ATP-independent) activity +namespace: molecular_function +def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] +comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. +synonym: "deoxyribonucleate topoisomerase" BROAD [] +synonym: "DNA topoisomerase I activity" NARROW [] +synonym: "nicking-closing enzyme activity" RELATED [EC:5.6.2.1] +synonym: "omega-protein activity" RELATED [EC:5.6.2.1] +synonym: "relaxing enzyme activity" RELATED [EC:5.6.2.1] +synonym: "swivelase activity" RELATED [EC:5.6.2.1] +synonym: "topoisomerase" BROAD [EC:5.6.2.1] +synonym: "type I DNA topoisomerase activity" EXACT [] +synonym: "type I topoisomerase activity" EXACT [] +synonym: "untwisting enzyme activity" RELATED [EC:5.6.2.1] +xref: EC:5.6.2.1 +xref: MetaCyc:5.99.1.2-RXN +is_a: GO:0003916 ! DNA topoisomerase activity + +[Term] +id: GO:0003918 +name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity +namespace: molecular_function +alt_id: GO:0061505 +def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2." [PMID:8811192] +synonym: "deoxyribonucleate topoisomerase" BROAD [GOC:krc] +synonym: "deoxyribonucleic topoisomerase activity" BROAD [EC:5.6.2.2, GOC:krc] +synonym: "DNA topoisomerase (ATP-hydrolysing)" RELATED [EC:5.6.2.2, GOC:krc] +synonym: "DNA topoisomerase II" NARROW [EC:5.6.2.2, GOC:krc] +synonym: "DNA topoisomerase II activity" NARROW [GOC:krc] +synonym: "DNA topoisomerase IV activity" NARROW [GOC:krc] +synonym: "DNA topoisomerase type II activity" EXACT [GOC:krc] +synonym: "topoisomerase" BROAD [EC:5.6.2.2, GOC:krc] +synonym: "topoisomerase II" NARROW [GOC:krc] +synonym: "type II DNA topoisomerase activity" RELATED [EC:5.6.2.2, GOC:krc] +xref: EC:5.6.2.2 +xref: MetaCyc:5.99.1.3-RXN +xref: Wikipedia:Type_II_topoisomerase +is_a: GO:0003916 ! DNA topoisomerase activity +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0003919 +name: FMN adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17237] +synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" RELATED [EC:2.7.7.2] +synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" RELATED [EC:2.7.7.2] +synonym: "ATP:FMN adenylyltransferase activity" EXACT [] +synonym: "FAD diphosphorylase activity" RELATED [EC:2.7.7.2] +synonym: "FAD pyrophosphorylase activity" RELATED [EC:2.7.7.2] +synonym: "FAD synthetase activity" RELATED [EC:2.7.7.2] +synonym: "flavin adenine dinucleotide synthetase activity" RELATED [EC:2.7.7.2] +synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.2] +synonym: "riboflavin mononucleotide adenylyltransferase activity" RELATED [EC:2.7.7.2] +synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" RELATED [EC:2.7.7.2] +xref: EC:2.7.7.2 +xref: KEGG_REACTION:R00161 +xref: MetaCyc:FADSYN-RXN +xref: Reactome:R-HSA-196929 "FLAD1 phosphorylates FMN" +xref: RHEA:17237 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0003920 +name: GMP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17185] +comment: Note that this function was formerly EC:1.6.6.8. +synonym: "guanosine 5'-monophosphate oxidoreductase activity" RELATED [EC:1.7.1.7] +synonym: "guanosine 5'-monophosphate reductase activity" RELATED [EC:1.7.1.7] +synonym: "guanosine 5'-phosphate reductase activity" RELATED [EC:1.7.1.7] +synonym: "guanosine monophosphate reductase activity" RELATED [EC:1.7.1.7] +synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] +synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" RELATED [EC:1.7.1.7] +synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" RELATED [EC:1.7.1.7] +synonym: "NADPH:GMP oxidoreductase (deaminating) activity" RELATED [EC:1.7.1.7] +synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" RELATED [EC:1.7.1.7] +xref: EC:1.7.1.7 +xref: KEGG_REACTION:R01134 +xref: MetaCyc:GMP-REDUCT-RXN +xref: Reactome:R-HSA-514604 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)" +xref: RHEA:17185 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0003921 +name: GMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+)." [RHEA:18301] +xref: MetaCyc:GMP-SYN-NH3-RXN +xref: RHEA:18301 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds +relationship: part_of GO:0003922 ! GMP synthase (glutamine-hydrolyzing) activity + +[Term] +id: GO:0003922 +name: GMP synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+)." [RHEA:11680] +synonym: "glutamine amidotransferase activity" RELATED [EC:6.3.5.2] +synonym: "GMP synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.2] +synonym: "GMP synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.2] +synonym: "GMP synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.2] +synonym: "guanosine 5'-monophosphate synthetase activity" RELATED [EC:6.3.5.2] +synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.2] +synonym: "guanylate synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.2] +synonym: "xanthosine 5'-phosphate amidotransferase activity" RELATED [EC:6.3.5.2] +synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.2] +xref: EC:6.3.5.2 +xref: MetaCyc:GMP-SYN-GLUT-RXN +xref: Reactome:R-HSA-73792 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate" +xref: RHEA:11680 +xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0003923 +name: GPI-anchor transamidase activity +namespace: molecular_function +def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309] +xref: Reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide" +is_a: GO:0004197 ! cysteine-type endopeptidase activity + +[Term] +id: GO:0003924 +name: GTPase activity +namespace: molecular_function +alt_id: GO:0061745 +def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684, PMID:26832457, PMID:27218782] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_yeast +synonym: "ARF small monomeric GTPase activity" NARROW [] +synonym: "dynamin GTPase activity" NARROW [] +synonym: "GTPase activity, coupled" RELATED [] +synonym: "heterotrimeric G-protein GTPase activity" NARROW [] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] +synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] +synonym: "protein-synthesizing GTPase activity" NARROW [] +synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] +synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] +synonym: "protein-synthesizing GTPase activity, termination" NARROW [] +synonym: "Rab small monomeric GTPase activity" NARROW [] +synonym: "Ran small monomeric GTPase activity" NARROW [] +synonym: "Ras small monomeric GTPase activity" NARROW [] +synonym: "RHEB small monomeric GTPase activity" NARROW [] +synonym: "Rho small monomeric GTPase activity" NARROW [] +synonym: "Sar small monomeric GTPase activity" NARROW [] +synonym: "signal-recognition-particle GTPase activity" NARROW [] +synonym: "small monomeric GTPase activity" NARROW [] +synonym: "tubulin GTPase activity" NARROW [] +xref: Reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP" +xref: Reactome:R-HSA-1458485 "RALA hydrolyzes GTP" +xref: Reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP" +xref: Reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP" +xref: Reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP" +xref: Reactome:R-HSA-167415 "G-protein alpha subunit is inactivated" +xref: Reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf" +xref: Reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf" +xref: Reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha" +xref: Reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle" +xref: Reactome:R-HSA-203973 "Vesicle budding" +xref: Reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome" +xref: Reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle" +xref: Reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP" +xref: Reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP" +xref: Reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP" +xref: Reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP" +xref: Reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP" +xref: Reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP" +xref: Reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission" +xref: Reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha" +xref: Reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission" +xref: Reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC" +xref: Reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA" +xref: Reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome" +xref: Reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits" +xref: Reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)" +xref: Reactome:R-HSA-555065 "Formation of clathrin coated vesicle" +xref: Reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4" +xref: Reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP" +xref: Reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity" +xref: Reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" +xref: Reactome:R-HSA-5672017 "Rheb in the MTORC1 complex hydrolyses GTP" +xref: Reactome:R-HSA-5694527 "Loss of SAR1B GTPase" +xref: Reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity" +xref: Reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP" +xref: Reactome:R-HSA-8847534 "RAB43 hydrolyses GTP" +xref: Reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity" +xref: Reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity" +xref: Reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35" +xref: Reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7" +xref: Reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7" +xref: Reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A" +xref: Reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B" +xref: Reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission" +xref: Reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity" +xref: Reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated" +xref: Reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated" +xref: Reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated" +xref: Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP" +xref: Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP" +xref: Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP" +xref: Reactome:R-HSA-983422 "Disassembly of COPII coated vesicle" +xref: RHEA:19669 +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0003925 +name: G protein activity +namespace: molecular_function +alt_id: GO:0003927 +def: "A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP)." [PMID:16923326, PMID:24470015] +synonym: "heterotrimeric G-protein GTPase activity" NARROW [] +synonym: "large G-protein activity" NARROW [] +synonym: "large G-protein GTPase activity" NARROW [] +synonym: "signaling G protein activity" EXACT [] +synonym: "small monomeric G protein activity" NARROW [] +synonym: "small monomeric GTPase activity" NARROW [] +xref: EC:3.6.5.1 +xref: EC:3.6.5.2 +xref: MetaCyc:3.6.1.46-RXN +xref: MetaCyc:3.6.1.47-RXN +is_a: GO:0003924 ! GTPase activity +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0003926 +name: obsolete ARF small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "ARF small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0016191 +consider: GO:0016192 + +[Term] +id: GO:0003928 +name: obsolete RAB small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "RAB small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0016191 +consider: GO:0016192 + +[Term] +id: GO:0003929 +name: obsolete RAN small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "RAN small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0006606 + +[Term] +id: GO:0003930 +name: obsolete RAS small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "RAS small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0001558 + +[Term] +id: GO:0003931 +name: obsolete Rho small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "Rho small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0007010 + +[Term] +id: GO:0003932 +name: obsolete SAR small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] +comment: This term was made obsolete because it represents a gene product. +synonym: "SAR small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0046903 + +[Term] +id: GO:0003933 +name: GTP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators] +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0003934 +name: GTP cyclohydrolase I activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] +synonym: "dihydroneopterin triphosphate synthase activity" RELATED [EC:3.5.4.16] +synonym: "GTP 7,8-8,9-dihydrolase activity" RELATED [EC:3.5.4.16] +synonym: "GTP 8-formylhydrolase activity" RELATED [EC:3.5.4.16] +synonym: "guanosine triphosphate 8-deformylase activity" RELATED [EC:3.5.4.16] +synonym: "guanosine triphosphate cyclohydrolase activity" RELATED [EC:3.5.4.16] +xref: EC:3.5.4.16 +xref: KEGG_REACTION:R00424 +xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN +xref: Reactome:R-HSA-1474146 "GCH1 reduces GTP to dihydroneopterin triphosphate" +xref: RHEA:17473 +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0003935 +name: GTP cyclohydrolase II activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23704] +synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" RELATED [EC:3.5.4.25] +synonym: "GTP-8-formylhydrolase activity" RELATED [EC:3.5.4.25] +synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] +xref: EC:3.5.4.25 +xref: KEGG_REACTION:R00425 +xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN +xref: RHEA:23704 +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0003936 +name: obsolete hydrogen-transporting two-sector ATPase activity +namespace: molecular_function +alt_id: GO:0004006 +alt_id: GO:0008729 +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] +comment: This term was made obsolete because it refers to a bifunctional gene product. +synonym: "hydrogen-transporting two-sector ATPase activity" EXACT [] +synonym: "proton-transporting two-sector ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046933 +consider: GO:0046961 + +[Term] +id: GO:0003937 +name: IMP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] +synonym: "IMP 1,2-hydrolase (decyclizing)" RELATED [EC:3.5.4.10] +synonym: "IMP synthetase activity" RELATED [EC:3.5.4.10] +synonym: "inosinate cyclohydrolase activity" RELATED [EC:3.5.4.10] +synonym: "inosinicase activity" RELATED [EC:3.5.4.10] +xref: EC:3.5.4.10 +xref: MetaCyc:IMPCYCLOHYDROLASE-RXN +xref: Reactome:R-HSA-73797 "FAICAR => IMP + H2O" +xref: RHEA:18445 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0003938 +name: IMP dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] +synonym: "IMP oxidoreductase activity" RELATED [EC:1.1.1.205] +synonym: "IMP:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.205] +synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] +synonym: "inosine 5'-monophosphate dehydrogenase activity" RELATED [EC:1.1.1.205] +synonym: "inosine monophosphate dehydrogenase activity" RELATED [EC:1.1.1.205] +synonym: "inosine monophosphate oxidoreductase activity" RELATED [EC:1.1.1.205] +synonym: "inosine-5'-phosphate dehydrogenase activity" RELATED [EC:1.1.1.205] +synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] +xref: EC:1.1.1.205 +xref: MetaCyc:IMP-DEHYDROG-RXN +xref: Reactome:R-HSA-73794 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]" +xref: RHEA:11708 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003939 +name: L-iditol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] +comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. +synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "L-iditol:NAD oxidoreductase activity" RELATED [EC:1.1.1.14] +synonym: "L-iditol:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.14] +synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] +synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] +synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] +xref: EC:1.1.1.14 +xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-5652195 "SORD oxidizes D-sorbitol to Fru" +xref: RHEA:10160 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003940 +name: L-iduronidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] +synonym: "alpha-L-iduronidase activity" RELATED [EC:3.2.1.76] +synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" RELATED [EC:3.2.1.76] +xref: EC:3.2.1.76 +xref: MetaCyc:3.2.1.76-RXN +xref: Reactome:R-HSA-1678716 "IDUA hydrolyses Heparan sulfate chain(1)" +xref: Reactome:R-HSA-1793186 "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS" +xref: Reactome:R-HSA-2090037 "IDUA hydrolyses Heparan sulfate chain(6)" +xref: Reactome:R-HSA-2206299 "Defective IDUA does not hydrolyse Heparan sulfate chain(6)" +xref: Reactome:R-HSA-9036037 "Defective IDUA does not hydrolyse Heparan sulfate chain(1)" +xref: Reactome:R-HSA-9036041 "Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0003941 +name: L-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] +comment: Note that this function was formerly EC:4.3.1.13. +synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] +synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" RELATED [EC:4.3.1.17] +synonym: "L-serine deaminase activity" EXACT [] +synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] +synonym: "L-serine dehydration activity" RELATED [] +synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] +synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] +xref: EC:4.3.1.17 +xref: MetaCyc:4.3.1.17-RXN +xref: RHEA:19169 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0003942 +name: N-acetyl-gamma-glutamyl-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] +synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38] +synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.38] +synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.38] +synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38] +synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.38] +synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] +synonym: "reductase, acetyl-gamma-glutamyl phosphate" RELATED [EC:1.2.1.38] +xref: EC:1.2.1.38 +xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN +xref: RHEA:21588 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003943 +name: N-acetylgalactosamine-4-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] +synonym: "acetylgalactosamine 4-sulfatase activity" RELATED [EC:3.1.6.12] +synonym: "arylsulfatase B" EXACT [] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] +synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" RELATED [EC:3.1.6.12] +synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.12] +synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] +xref: EC:3.1.6.12 +xref: MetaCyc:3.1.6.12-RXN +xref: Reactome:R-HSA-1606789 "ARSB hydrolyses DS" +xref: Reactome:R-HSA-1793207 "ARSB hydrolyses C4S/C6S chains" +xref: Reactome:R-HSA-2282889 "Defective ARSB does not hydrolyse C4S/C6S chains" +xref: Reactome:R-HSA-9036065 "Defective ARSB does not hydrolyse DS" +xref: Wikipedia:Arylsulfatase_B +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0003944 +name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] +synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" RELATED [EC:3.1.4.45] +synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" RELATED [EC:3.1.4.45] +synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" RELATED [EC:3.1.4.45] +synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" RELATED [EC:3.1.4.45] +synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] +synonym: "phosphodiester glycosidase activity" RELATED [EC:3.1.4.45] +xref: EC:3.1.4.45 +xref: MetaCyc:3.1.4.45-RXN +xref: RHEA:24372 +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0003945 +name: N-acetyllactosamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] +synonym: "acetyllactosamine synthetase activity" RELATED [EC:2.4.1.90] +synonym: "beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90] +synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "Gal-T" RELATED [EC:2.4.1.90] +synonym: "lactosamine synthase activity" RELATED [EC:2.4.1.90] +synonym: "lactosamine synthetase activity" RELATED [EC:2.4.1.90] +synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] +synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "N-acetyllactosamine synthetase activity" RELATED [EC:2.4.1.90] +synonym: "NAL synthetase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" RELATED [EC:2.4.1.90] +synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" RELATED [EC:2.4.1.90] +xref: EC:2.4.1.90 +xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN +xref: RHEA:17745 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0003947 +name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] +synonym: "asialo-GM2 synthase activity" RELATED [EC:2.4.1.92] +synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "GalNAc-T activity" RELATED [EC:2.4.1.92] +synonym: "ganglioside GM2 synthase activity" RELATED [EC:2.4.1.92] +synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "GM2 synthase activity" RELATED [EC:2.4.1.92] +synonym: "GM2/GD2-synthase activity" RELATED [EC:2.4.1.92] +synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.92] +xref: EC:2.4.1.92 +xref: MetaCyc:2.4.1.92-RXN +xref: Reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides" +xref: RHEA:12588 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0003948 +name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11544] +synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.26] +synonym: "aspartylglucosaminidase activity" RELATED [EC:3.5.1.26] +synonym: "aspartylglucosylaminase activity" RELATED [EC:3.5.1.26] +synonym: "aspartylglucosylamine deaspartylase activity" RELATED [EC:3.5.1.26] +synonym: "aspartylglucosylaminidase activity" RELATED [EC:3.5.1.26] +synonym: "aspartylglycosylamine amidohydrolase activity" RELATED [EC:3.5.1.26] +synonym: "beta-aspartylglucosylamine amidohydrolase activity" RELATED [EC:3.5.1.26] +synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] +synonym: "glycosylasparaginase activity" RELATED [EC:3.5.1.26] +synonym: "N-aspartyl-beta-glucosaminidase activity" RELATED [EC:3.5.1.26] +synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.26] +xref: EC:3.5.1.26 +xref: KEGG_REACTION:R03421 +xref: MetaCyc:3.5.1.26-RXN +xref: RHEA:11544 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0003949 +name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15469] +synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" RELATED [EC:5.3.1.16] +synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" RELATED [EC:5.3.1.16] +synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16] +synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16] +synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" RELATED [EC:5.3.1.16] +synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" RELATED [EC:5.3.1.16] +xref: EC:5.3.1.16 +xref: KEGG_REACTION:R04640 +xref: MetaCyc:PRIBFAICARPISOM-RXN +xref: RHEA:15469 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0003950 +name: NAD+ ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] +synonym: "ADP-ribosyltransferase (polymerizing) activity" RELATED [EC:2.4.2.30] +synonym: "NAD ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" RELATED [EC:2.4.2.30] +synonym: "poly(adenosine diphosphate ribose) polymerase activity" RELATED [EC:2.4.2.30] +synonym: "poly(ADP-ribose) synthase activity" RELATED [EC:2.4.2.30] +synonym: "poly(ADP-ribose) synthetase activity" RELATED [EC:2.4.2.30] +synonym: "poly(ADP-ribose)polymerase activity" RELATED [EC:2.4.2.30] +xref: EC:2.4.2.30 +xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4" +xref: Reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN" +xref: Reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate" +xref: Reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate" +xref: Reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD" +xref: Reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)" +xref: Reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN" +xref: Reactome:R-HSA-9686061 "Nucleoprotein is ADP-ribosylated" +xref: Reactome:R-HSA-9694773 "Nucleoprotein is ADP-ribosylated" +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0003951 +name: NAD+ kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18629] +synonym: "ATP:NAD+ 2'-phosphotransferase activity" RELATED [EC:2.7.1.23] +synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] +synonym: "NAD kinase activity" EXACT [] +synonym: "NADK" RELATED [EC:2.7.1.23] +synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" RELATED [EC:2.7.1.23] +synonym: "nicotinamide adenine dinucleotide kinase activity" RELATED [EC:2.7.1.23] +xref: EC:2.7.1.23 +xref: KEGG_REACTION:R00104 +xref: MetaCyc:NAD-KIN-RXN +xref: Reactome:R-HSA-197198 "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+" +xref: Reactome:R-HSA-8955030 "NADK2 dimer phosphorylates NAD+ to NADP+" +xref: RHEA:18629 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0003952 +name: NAD+ synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] +synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.1] +synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" RELATED [EC:6.3.5.1] +synonym: "DPN synthetase activity" RELATED [EC:6.3.5.1] +synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] +synonym: "NAD synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.1] +synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.1] +synonym: "NAD+ synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.1] +synonym: "NAD+ synthetase (glutamine-hydrolyzing)" RELATED [EC:6.3.5.1] +synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" RELATED [EC:6.3.5.1] +xref: EC:6.3.5.1 +xref: MetaCyc:NAD-SYNTH-GLN-RXN +xref: Reactome:R-HSA-197271 "NADSYN1 hexamer amidates NAAD to NAD+" +xref: RHEA:24384 +xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0003953 +name: NAD+ nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847] +synonym: "NAD nucleosidase activity" EXACT [] +xref: Reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose" +xref: Reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose" +xref: RHEA:16301 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0003954 +name: NADH dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [RHEA:11356] +synonym: "beta-NADH dehydrogenase dinucleotide activity" RELATED [] +synonym: "cytochrome c reductase activity" RELATED [] +synonym: "diaphorase activity" BROAD [] +synonym: "dihydrocodehydrogenase I dehydrogenase activity" RELATED [] +synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" RELATED [] +synonym: "diphosphopyridine diaphorase activity" RELATED [] +synonym: "diphosphopyrinase activity" RELATED [] +synonym: "DPNH diaphorase activity" RELATED [] +synonym: "NADH diaphorase activity" RELATED [] +synonym: "NADH hydrogenase activity" RELATED [] +synonym: "NADH oxidoreductase activity" RELATED [] +synonym: "NADH-menadione oxidoreductase activity" NARROW [] +synonym: "NADH2 dehydrogenase activity" RELATED [] +synonym: "NADH:(acceptor) oxidoreductase activity" RELATED [] +synonym: "NADH:acceptor oxidoreductase activity" RELATED [] +synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [] +synonym: "reduced diphosphopyridine nucleotide diaphorase activity" RELATED [] +synonym: "type 1 dehydrogenase activity" RELATED [] +synonym: "type I dehydrogenase activity" RELATED [] +xref: MetaCyc:NADH-DEHYDROGENASE-RXN +xref: RHEA:11356 +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0003955 +name: NAD(P)H dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2] +synonym: "azoreductase activity" BROAD [EC:1.6.5.2] +synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" RELATED [EC:1.6.5.2] +synonym: "diaphorase activity" BROAD [EC:1.6.5.2] +synonym: "DT-diaphorase activity" RELATED [EC:1.6.5.2] +synonym: "flavoprotein NAD(P)H-quinone reductase activity" RELATED [EC:1.6.5.2] +synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] +synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] +synonym: "NAD(P)H dehydrogenase activity" BROAD [] +synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] +synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" RELATED [EC:1.6.5.2] +synonym: "NAD(P)H-quinone dehydrogenase activity" RELATED [EC:1.6.5.2] +synonym: "NAD(P)H-quinone oxidoreductase activity" RELATED [EC:1.6.5.2] +synonym: "NAD(P)H2 dehydrogenase (quinone)" RELATED [EC:1.6.5.2] +synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] +synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" RELATED [EC:1.6.5.2] +synonym: "NAD(P)H:quinone oxidoreductase activity" RELATED [EC:1.6.5.2] +synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] +synonym: "naphthoquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "NQO1" RELATED [] +synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] +synonym: "QR1" RELATED [] +synonym: "quinone reductase activity" RELATED [EC:1.6.5.2] +synonym: "reduced NAD(P)H dehydrogenase activity" RELATED [EC:1.6.5.2] +synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" RELATED [EC:1.6.5.2] +synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] +synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] +synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] +xref: EC:1.6.5.2 +xref: MetaCyc:NQOR-RXN +xref: UM-BBD_reactionID:r0227 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0003956 +name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] +synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] +synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] +synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" RELATED [EC:2.4.2.31] +synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" RELATED [EC:2.4.2.31] +synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" RELATED [EC:2.4.2.31] +synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" RELATED [EC:2.4.2.31] +synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] +synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" RELATED [EC:2.4.2.31] +synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] +synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.31 +xref: MetaCyc:2.4.2.31-RXN +xref: Reactome:R-HSA-1972385 "ADP-Ribosylation of HNP-1" +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0003957 +name: NAD(P)+ transhydrogenase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1] +synonym: "H+-thase" BROAD [EC:1.6.1.1] +synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] +synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] +synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "NADPH:NAD+ oxidoreductase (B-specific)" RELATED [EC:1.6.1.1] +synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] +synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] +synonym: "non-energy-linked transhydrogenase activity" RELATED [EC:1.6.1.1] +synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] +synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] +xref: EC:1.6.1.1 +xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN +is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity +is_a: GO:0015078 ! proton transmembrane transporter activity + +[Term] +id: GO:0003958 +name: NADPH-hemoprotein reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] +synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] +synonym: "CPR activity" RELATED [EC:1.6.2.4] +synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] +synonym: "cytochrome P-450 reductase activity" RELATED [EC:1.6.2.4] +synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] +synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] +synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH-cytochrome P-450 oxidoreductase activity" RELATED [EC:1.6.2.4] +synonym: "NADPH-cytochrome p-450 reductase activity" RELATED [EC:1.6.2.4] +synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] +synonym: "NADPH:cytochrome c reductase activity" EXACT [] +synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] +synonym: "NADPH:ferrihemoprotein oxidoreductase activity" RELATED [EC:1.6.2.4] +synonym: "NADPH:hemoprotein oxidoreductase activity" RELATED [EC:1.6.2.4] +synonym: "NADPH:P-450 reductase activity" RELATED [EC:1.6.2.4] +synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] +synonym: "POR" RELATED [EC:1.6.2.4] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] +synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] +synonym: "TPNH2 cytochrome c reductase activity" RELATED [EC:1.6.2.4] +xref: EC:1.6.2.4 +xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN +xref: Reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+" +xref: RHEA:24040 +is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor + +[Term] +id: GO:0003959 +name: NADPH dehydrogenase activity +namespace: molecular_function +alt_id: GO:0008468 +alt_id: GO:0016660 +def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [RHEA:13149] +synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH diaphorase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH-dehydrogenase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH2 diaphorase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH2-dehydrogenase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH:(acceptor) oxidoreductase activity" RELATED [EC:1.6.99.1] +synonym: "NADPH:acceptor oxidoreductase activity" RELATED [EC:1.6.99.1] +synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] +synonym: "OYE" RELATED [EC:1.6.99.1] +synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" RELATED [EC:1.6.99.1] +synonym: "TPNH dehydrogenase activity" RELATED [EC:1.6.99.1] +synonym: "TPNH-diaphorase activity" RELATED [EC:1.6.99.1] +synonym: "triphosphopyridine diaphorase activity" RELATED [EC:1.6.99.1] +synonym: "triphosphopyridine nucleotide diaphorase activity" RELATED [EC:1.6.99.1] +xref: EC:1.6.99.1 +xref: MetaCyc:NADPH-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-9018867 "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2" +xref: Reactome:R-HSA-9018901 "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2" +xref: Reactome:R-HSA-9027625 "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3" +xref: Reactome:R-HSA-9027631 "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA" +xref: Reactome:R-HSA-9027632 "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA" +xref: RHEA:13149 +xref: UM-BBD_enzymeID:e0523 +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0003960 +name: NADPH:quinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] +synonym: "NADPH:quinone oxidoreductase activity" RELATED [EC:1.6.5.5] +synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] +synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] +xref: EC:1.6.5.5 +xref: MetaCyc:QOR-RXN +xref: Reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones" +xref: RHEA:14269 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0003961 +name: O-acetylhomoserine aminocarboxypropyltransferase activity +namespace: molecular_function +alt_id: GO:0019282 +def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49] +comment: Note that this function was formerly EC:4.2.99.10. +synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] +synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [] +synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] +synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] +synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" RELATED [EC:2.5.1.49] +synonym: "O-acetyl-L-homoserine sulfhydrolase activity" RELATED [EC:2.5.1.49] +synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.49] +synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] +synonym: "O-acetylhomoserine sulfhydrolase activity" RELATED [EC:2.5.1.49] +synonym: "OAH sulfhydrylase activity" RELATED [EC:2.5.1.49] +xref: EC:2.5.1.49 +xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN +xref: RHEA:10048 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003962 +name: cystathionine gamma-synthase activity +namespace: molecular_function +alt_id: GO:0000505 +def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] +synonym: "CTT gamma synthase activity" EXACT [] +synonym: "cystathionine g-synthase activity" EXACT [] +synonym: "cystathionine gamma synthase activity" EXACT [] +synonym: "cystathionine synthase activity" RELATED [EC:2.5.1.48] +synonym: "cystathionine synthetase activity" RELATED [EC:2.5.1.48] +synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] +synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] +synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] +synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" RELATED [EC:2.5.1.48] +synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] +synonym: "O-succinylhomoserine (thiol)-lyase activity" RELATED [EC:2.5.1.48] +synonym: "O-succinylhomoserine synthase activity" RELATED [EC:2.5.1.48] +synonym: "O-succinylhomoserine synthetase activity" RELATED [EC:2.5.1.48] +synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" RELATED [EC:2.5.1.48] +xref: EC:2.5.1.48 +xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN +xref: RHEA:20397 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0003963 +name: RNA-3'-phosphate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] +synonym: "RNA 3'-terminal phosphate cyclase activity" RELATED [EC:6.5.1.4] +synonym: "RNA cyclase activity" RELATED [EC:6.5.1.4] +synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" RELATED [EC:6.5.1.4] +xref: EC:6.5.1.4 +xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN +xref: RHEA:23976 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0003964 +name: RNA-directed DNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] +synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" RELATED [EC:2.7.7.49] +synonym: "DNA nucleotidyltransferase (RNA-directed) activity" RELATED [EC:2.7.7.49] +synonym: "reverse transcriptase activity" RELATED [EC:2.7.7.49] +synonym: "revertase activity" RELATED [EC:2.7.7.49] +synonym: "RNA revertase activity" RELATED [EC:2.7.7.49] +synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.49] +synonym: "RNA-dependent DNA polymerase activity" RELATED [EC:2.7.7.49] +synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] +synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] +synonym: "RNA-instructed DNA polymerase activity" RELATED [EC:2.7.7.49] +synonym: "RT" RELATED [EC:2.7.7.49] +xref: EC:2.7.7.49 +xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN +xref: Reactome:R-HSA-164504 "Synthesis of minus strand strong stop DNA (-sssDNA)" +xref: Reactome:R-HSA-164520 "Minus strand DNA synthesis resumes" +is_a: GO:0034061 ! DNA polymerase activity + +[Term] +id: GO:0003966 +name: obsolete RNA-directed DNA polymerase, transposon encoded +namespace: molecular_function +def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] +comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. +synonym: "RNA-directed DNA polymerase, transposon encoded" EXACT [] +is_obsolete: true +replaced_by: GO:0003964 + +[Term] +id: GO:0003967 +name: obsolete RNA-directed DNA polymerase, group II intron encoded +namespace: molecular_function +def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] +comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. +synonym: "RNA-directed DNA polymerase, group II intron encoded" EXACT [] +is_obsolete: true +replaced_by: GO:0003964 + +[Term] +id: GO:0003968 +name: RNA-directed 5'-3' RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf] +synonym: "3D polymerase activity" RELATED [EC:2.7.7.48] +synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" RELATED [EC:2.7.7.48] +synonym: "PB1 proteins" RELATED [EC:2.7.7.48] +synonym: "PB2 proteins" RELATED [EC:2.7.7.48] +synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] +synonym: "polymerase L" RELATED [EC:2.7.7.48] +synonym: "Q-beta replicase activity" RELATED [EC:2.7.7.48] +synonym: "RDRP" RELATED [EC:2.7.7.48] +synonym: "ribonucleic acid replicase activity" RELATED [EC:2.7.7.48] +synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.48] +synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" RELATED [EC:2.7.7.48] +synonym: "ribonucleic replicase activity" RELATED [EC:2.7.7.48] +synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] +synonym: "RNA nucleotidyltransferase (RNA-directed) activity" RELATED [EC:2.7.7.48] +synonym: "RNA replicase activity" RELATED [EC:2.7.7.48] +synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] +synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.48] +synonym: "RNA-dependent RNA polymerase activity" RELATED [EC:2.7.7.48] +synonym: "RNA-dependent RNA replicase activity" RELATED [EC:2.7.7.48] +synonym: "RNA-directed RNA polymerase activity" BROAD [] +synonym: "transcriptase" BROAD [EC:2.7.7.48] +xref: EC:2.7.7.48 +xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN +xref: Reactome:R-HSA-168280 "Priming and Initiation of Transcription" +xref: Reactome:R-HSA-168301 "Elongation, Polyadenylation and Termination" +xref: Reactome:R-HSA-192624 "cRNA Extension" +xref: Reactome:R-HSA-192832 "Initiation of cRNA Synthesis" +xref: Reactome:R-HSA-192851 "vRNA Extension" +xref: Reactome:R-HSA-192916 "Initiation of vRNA Synthesis" +xref: Reactome:R-HSA-9681651 "nsp8 generates RNA primers" +xref: Reactome:R-HSA-9681674 "nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement" +xref: Reactome:R-HSA-9681840 "RTC synthesizes SARS-CoV-1 plus strand genomic RNA" +xref: Reactome:R-HSA-9682465 "RTC completes synthesis of the minus strand genomic RNA complement" +xref: Reactome:R-HSA-9682563 "nsp12 misincorporates a nucleotide in nascent RNA minus strand" +xref: Reactome:R-HSA-9685639 "Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching" +xref: Reactome:R-HSA-9685681 "Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs" +xref: Reactome:R-HSA-9694277 "nsp8 generates RNA primers" +xref: Reactome:R-HSA-9694344 "Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching" +xref: Reactome:R-HSA-9694506 "Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs" +xref: Reactome:R-HSA-9694549 "RTC completes synthesis of the minus strand genomic RNA complement" +xref: Reactome:R-HSA-9694581 "RTC synthesizes SARS-CoV-2 plus strand genomic RNA" +xref: Reactome:R-HSA-9694605 "nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement" +xref: Reactome:R-HSA-9694792 "nsp12 misincorporates a nucleotide in nascent RNA minus strand" +is_a: GO:0034062 ! 5'-3' RNA polymerase activity + +[Term] +id: GO:0003969 +name: obsolete RNA editase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a biological process. +synonym: "RNA editase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0003972 +name: RNA ligase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3] +synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" RELATED [EC:6.5.1.3] +synonym: "polyribonucleotide ligase activity" RELATED [EC:6.5.1.3] +synonym: "polyribonucleotide synthase (ATP) activity" RELATED [EC:6.5.1.3] +synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] +xref: EC:6.5.1.3 +xref: MetaCyc:RNA-LIGASE-ATP-RXN +xref: Reactome:R-HSA-5696816 "tRNA ligase complex ligates tRNA exons" +is_a: GO:0008452 ! RNA ligase activity + +[Term] +id: GO:0003973 +name: (S)-2-hydroxy-acid oxidase activity +namespace: molecular_function +alt_id: GO:0008891 +alt_id: GO:0052852 +alt_id: GO:0052853 +alt_id: GO:0052854 +def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [RHEA:16789] +synonym: "glycolate oxidase activity" RELATED [] +synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] +synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] +synonym: "hydroxyacid oxidase A" RELATED [] +synonym: "L-2-hydroxy acid oxidase" RELATED [] +synonym: "L-alpha-hydroxy acid oxidase" RELATED [] +synonym: "long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity" NARROW [] +synonym: "medium-chain-(S)-2-hydroxy-acid oxidase activity" NARROW [] +synonym: "very-long-chain-(S)-2-hydroxy-acid oxidase activity" NARROW [] +xref: EC:1.1.3.15 +xref: MetaCyc:RXN-969 +xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN +xref: Reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate" +xref: Reactome:R-HSA-6787811 "HAO2 tetramer oxidises 2OH-PALM" +xref: RHEA:16789 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0003974 +name: UDP-N-acetylglucosamine 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] +synonym: "UDP acetylglucosamine epimerase activity" RELATED [EC:5.1.3.7] +synonym: "UDP-GlcNAc 4-epimerase activity" RELATED [EC:5.1.3.7] +synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" RELATED [EC:5.1.3.7] +synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" RELATED [EC:5.1.3.7] +synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" RELATED [EC:5.1.3.7] +synonym: "uridine diphosphoacetylglucosamine epimerase activity" RELATED [EC:5.1.3.7] +xref: EC:5.1.3.7 +xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN +xref: RHEA:20517 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0003975 +name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] +synonym: "chitobiosylpyrophosphoryldolichol synthase activity" RELATED [EC:2.7.8.15] +synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15] +synonym: "GlcNAc-1-P transferase activity" RELATED [EC:2.7.8.15] +synonym: "N-acetylglucosamine-1-phosphate transferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" RELATED [EC:2.7.8.15] +synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] +synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.15] +xref: EC:2.7.8.15 +xref: MetaCyc:2.7.8.15-RXN +xref: Reactome:R-HSA-446191 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate" +xref: Reactome:R-HSA-4549334 "Defective DPAGT1 does not transfer GlcNAc to DOLP" +xref: RHEA:13289 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0003976 +name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] +synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "N-acetylglucosaminyl phosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" RELATED [EC:2.7.8.17] +synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" RELATED [EC:2.7.8.17] +xref: EC:2.7.8.17 +xref: MetaCyc:2.7.8.17-RXN +xref: RHEA:13581 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0003977 +name: UDP-N-acetylglucosamine diphosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13509] +synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] +synonym: "GlmU uridylyltransferase activity" RELATED [EC:2.7.7.23] +synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.23] +synonym: "UDP-acetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23] +synonym: "UDP-GlcNAc pyrophosphorylase activity" RELATED [EC:2.7.7.23] +synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] +synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23] +synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" RELATED [EC:2.7.7.23] +synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" RELATED [EC:2.7.7.23] +synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.23] +synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.23] +xref: EC:2.7.7.23 +xref: KEGG_REACTION:R00416 +xref: MetaCyc:NAG1P-URIDYLTRANS-RXN +xref: Reactome:R-HSA-446204 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine" +xref: RHEA:13509 +is_a: GO:0070569 ! uridylyltransferase activity + +[Term] +id: GO:0003978 +name: UDP-glucose 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] +synonym: "4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] +synonym: "UDP-D-galactose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "UDP-galactose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "UDP-glucose epimerase activity" RELATED [EC:5.1.3.2] +synonym: "UDPG-4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "UDPgalactose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "UDPglucose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "uridine diphosphate galactose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "uridine diphosphate glucose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "uridine diphospho-galactose-4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "uridine diphosphoglucose 4-epimerase activity" RELATED [EC:5.1.3.2] +synonym: "uridine diphosphoglucose epimerase activity" RELATED [EC:5.1.3.2] +xref: EC:5.1.3.2 +xref: MetaCyc:UDPGLUCEPIM-RXN +xref: Reactome:R-HSA-5610036 "Defective GALE does not epimerise UDP-Gal to UDP-Glc" +xref: Reactome:R-HSA-70369 "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc" +xref: RHEA:22168 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0003979 +name: UDP-glucose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596] +xref: EC:1.1.1.22 +xref: KEGG_REACTION:R00286 +xref: MetaCyc:UGD-RXN +xref: Reactome:R-HSA-173597 "UDP-glucose is oxidised to UDP-glucuronate" +xref: RHEA:23596 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0003980 +name: UDP-glucose:glycoprotein glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828] +synonym: "UGGT activity" EXACT [] +xref: Reactome:R-HSA-548884 "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b" +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0003983 +name: UTP:glucose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889] +synonym: "glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9] +synonym: "UDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "UDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "UDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "UDPG phosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "UDPG pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "uridine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "uridine-diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.9] +synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9] +synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.9] +xref: EC:2.7.7.9 +xref: KEGG_REACTION:R00289 +xref: MetaCyc:GLUC1PURIDYLTRANS-RXN +xref: Reactome:R-HSA-70286 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose" +xref: RHEA:19889 +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0003984 +name: acetolactate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [RHEA:25249] +comment: Note that this function was formerly EC:4.1.3.18. +synonym: "acetohydroxy acid synthetase activity" RELATED [EC:2.2.1.6] +synonym: "acetohydroxyacid synthase activity" RELATED [EC:2.2.1.6] +synonym: "acetolactate pyruvate-lyase (carboxylating) activity" RELATED [EC:2.2.1.6] +synonym: "acetolactic synthetase activity" RELATED [EC:2.2.1.6] +synonym: "alpha-acetohydroxy acid synthetase activity" RELATED [EC:2.2.1.6] +synonym: "alpha-acetohydroxyacid synthase activity" RELATED [EC:2.2.1.6] +synonym: "alpha-acetolactate synthase activity" RELATED [EC:2.2.1.6] +synonym: "alpha-acetolactate synthetase activity" RELATED [EC:2.2.1.6] +synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.6] +xref: EC:2.2.1.6 +xref: MetaCyc:ACETOLACTSYN-RXN +xref: RHEA:25249 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0003985 +name: acetyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] +synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] +synonym: "3-oxothiolase activity" RELATED [EC:2.3.1.9] +synonym: "acetoacetyl-CoA thiolase activity" RELATED [EC:2.3.1.9] +synonym: "acetyl coenzyme A thiolase activity" RELATED [EC:2.3.1.9] +synonym: "acetyl-CoA acetyltransferase activity" RELATED [EC:2.3.1.9] +synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" RELATED [EC:2.3.1.9] +synonym: "acetyl-CoA:N-acetyltransferase activity" RELATED [EC:2.3.1.9] +synonym: "beta-acetoacetyl coenzyme A thiolase activity" RELATED [EC:2.3.1.9] +synonym: "thiolase II" RELATED [EC:2.3.1.9] +xref: EC:2.3.1.9 +xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN +xref: Reactome:R-HSA-70844 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA" +xref: Reactome:R-HSA-73916 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA" +xref: Reactome:R-HSA-74181 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA" +xref: Reactome:R-HSA-8848215 "ACAT2 condenses 2 Ac-CoA to form ACA-CoA" +xref: RHEA:21036 +xref: UM-BBD_enzymeID:e0144 +is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0003986 +name: acetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20289] +synonym: "acetyl coenzyme A acylase activity" RELATED [EC:3.1.2.1] +synonym: "acetyl coenzyme A deacylase activity" RELATED [EC:3.1.2.1] +synonym: "acetyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.1] +synonym: "acetyl-CoA acylase activity" RELATED [EC:3.1.2.1] +synonym: "acetyl-CoA deacylase activity" RELATED [EC:3.1.2.1] +synonym: "acetyl-CoA thiol esterase activity" RELATED [EC:3.1.2.1] +xref: EC:3.1.2.1 +xref: KEGG_REACTION:R00227 +xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN +xref: Reactome:R-HSA-2066779 "Conversion of DHA-CoA to docosahexaenoic acid (DHA)" +xref: Reactome:R-HSA-390304 "acetyl-CoA + H2O => acetate + CoASH" +xref: RHEA:20289 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0003987 +name: acetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] +synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] +synonym: "acetate to acetyl-CoA" RELATED [] +synonym: "acetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.1] +synonym: "acetic thiokinase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] +synonym: "acetyl CoA ligase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl CoA synthase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl coenzyme A synthetase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl-activating enzyme activity" RELATED [EC:6.2.1.1] +synonym: "acetyl-CoA synthase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl-CoA synthetase activity" RELATED [EC:6.2.1.1] +synonym: "acetyl-coenzyme A synthase activity" RELATED [EC:6.2.1.1] +synonym: "ACS" RELATED [EC:6.2.1.1] +synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] +synonym: "short chain fatty acyl-CoA synthetase activity" RELATED [EC:6.2.1.1] +synonym: "short-chain acyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.1] +xref: EC:6.2.1.1 +xref: MetaCyc:ACETATE--COA-LIGASE-RXN +xref: Reactome:R-HSA-449911 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]" +xref: Reactome:R-HSA-71735 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]" +xref: Reactome:R-HSA-8875071 "ACSS3 ligates CoA to CH3COO-" +xref: RHEA:23176 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0003988 +name: acetyl-CoA C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] +synonym: "2-keto-acyl thiolase activity" EXACT [] +synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [] +synonym: "3-ketoacyl CoA thiolase activity" RELATED [EC:2.3.1.16] +synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [] +synonym: "3-ketoacyl thiolase activity" EXACT [] +synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] +synonym: "3-ketothiolase activity" EXACT [] +synonym: "3-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "6-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [] +synonym: "acetyl-CoA acyltransferase activity" EXACT [] +synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" RELATED [EC:2.3.1.16] +synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [] +synonym: "beta-ketoacyl-CoA thiolase activity" NARROW [] +synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [] +synonym: "beta-ketoadipyl-CoA thiolase activity" NARROW [] +synonym: "beta-ketothiolase activity" EXACT [] +synonym: "KAT" RELATED [] +synonym: "ketoacyl-CoA acyltransferase activity" EXACT [] +synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [] +synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [] +synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [] +synonym: "thiolase I" RELATED [] +xref: EC:2.3.1.16 +xref: MetaCyc:KETOACYLCOATHIOL-RXN +xref: Reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA" +xref: Reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA" +xref: Reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA" +xref: Reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA" +xref: Reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA" +xref: Reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA" +xref: Reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA" +xref: Reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH" +xref: RHEA:21564 +xref: UM-BBD_reactionID:r1051 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0003989 +name: acetyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] +synonym: "acetyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.2] +synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.2] +xref: EC:6.4.1.2 +xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN +xref: Reactome:R-HSA-200555 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate" +xref: Reactome:R-HSA-75851 "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" +xref: Reactome:R-HSA-8876889 "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" +xref: RHEA:11308 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0003990 +name: acetylcholinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] +subset: goslim_chembl +synonym: "AcCholE" RELATED [EC:3.1.1.7] +synonym: "acetyl.beta-methylcholinesterase activity" RELATED [EC:3.1.1.7] +synonym: "acetylcholine acetylhydrolase activity" RELATED [EC:3.1.1.7] +synonym: "acetylcholine hydrolase activity" RELATED [EC:3.1.1.7] +synonym: "acetylthiocholinesterase activity" RELATED [EC:3.1.1.7] +synonym: "choline esterase I activity" RELATED [EC:3.1.1.7] +synonym: "true cholinesterase activity" RELATED [EC:3.1.1.7] +xref: EC:3.1.1.7 +xref: MetaCyc:ACETYLCHOLINESTERASE-RXN +xref: Reactome:R-HSA-372519 "AcCho is hydrolyzed to Cho and acetate by ACHE" +xref: RHEA:17561 +is_a: GO:0004104 ! cholinesterase activity + +[Term] +id: GO:0003991 +name: acetylglutamate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8] +synonym: "acetylglutamate phosphokinase activity" RELATED [EC:2.7.2.8] +synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.8] +synonym: "N-acetylglutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.8] +synonym: "N-acetylglutamate kinase activity" RELATED [EC:2.7.2.8] +synonym: "N-acetylglutamate phosphokinase activity" RELATED [EC:2.7.2.8] +synonym: "N-acetylglutamic 5-phosphotransferase activity" RELATED [EC:2.7.2.8] +xref: EC:2.7.2.8 +xref: MetaCyc:ACETYLGLUTKIN-RXN +xref: RHEA:14629 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0003992 +name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity +namespace: molecular_function +alt_id: GO:0047318 +def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18049] +synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" RELATED [EC:2.6.1.11] +synonym: "acetylornithine 5-aminotransferase activity" RELATED [EC:2.6.1.11] +synonym: "acetylornithine aminotransferase activity" BROAD [] +synonym: "acetylornithine delta-transaminase activity" RELATED [EC:2.6.1.11] +synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] +synonym: "ACOAT activity" RELATED [EC:2.6.1.11] +synonym: "N(2)-acetylornithine 5-transaminase activity" RELATED [EC:2.6.1.11] +synonym: "N-acetylornithine aminotransferase activity" RELATED [EC:2.6.1.11] +synonym: "N-acetylornithine-delta-transaminase activity" RELATED [EC:2.6.1.11] +synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.11] +synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] +synonym: "N2-acetylornithine 5-transaminase activity" RELATED [EC:2.6.1.11] +synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] +xref: EC:2.6.1.11 +xref: KEGG_REACTION:R02283 +xref: MetaCyc:ACETYLORNTRANSAM-RXN +xref: RHEA:18049 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0003993 +name: acid phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] +synonym: "acid monophosphatase activity" RELATED [EC:3.1.3.2] +synonym: "acid nucleoside diphosphate phosphatase activity" RELATED [EC:3.1.3.2] +synonym: "acid phosphohydrolase activity" RELATED [EC:3.1.3.2] +synonym: "acid phosphomonoester hydrolase activity" RELATED [EC:3.1.3.2] +synonym: "acid phosphomonoesterase activity" RELATED [EC:3.1.3.2] +synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] +synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" RELATED [EC:3.1.3.2] +synonym: "phosphate-monoester phosphohydrolase (acid optimum)" RELATED [EC:3.1.3.2] +synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] +synonym: "uteroferrin" RELATED [EC:3.1.3.2] +xref: EC:3.1.3.2 +xref: MetaCyc:ACID-PHOSPHATASE-RXN +xref: Reactome:R-HSA-196950 "2xTRAP hydrolyzes FMN to RIB" +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0003994 +name: aconitate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] +comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. +synonym: "aconitase activity" EXACT [] +synonym: "cis-aconitase activity" RELATED [EC:4.2.1.3] +synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" RELATED [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase activity" RELATED [EC:4.2.1.3] +xref: EC:4.2.1.3 +xref: Reactome:R-HSA-450975 "isocitrate <=> citrate" +xref: Reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT" +xref: Reactome:R-HSA-70971 "citrate <=> isocitrate" +xref: RHEA:10336 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0003995 +name: acyl-CoA dehydrogenase activity +namespace: molecular_function +alt_id: GO:0019109 +def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] +synonym: "acyl CoA dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "acyl coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "acyl dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] +synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" RELATED [EC:1.3.99.3] +synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" RELATED [EC:1.3.99.3] +synonym: "fatty acyl coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "fatty-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "general acyl CoA dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "long-chain acyl coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "long-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.3] +synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] +synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.3] +xref: EC:1.3.99.3 +xref: MetaCyc:ACYLCOADEHYDROG-RXN +xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN +xref: Reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" +xref: Reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA" +xref: Reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA" +xref: Reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2" +xref: Reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2" +xref: Reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2" +xref: Reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2" +xref: Reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2" +xref: Reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2" +xref: Reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2" +xref: Reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2" +xref: Reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2" +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0003997 +name: acyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] +synonym: "acyl coenzyme A oxidase activity" RELATED [EC:1.3.3.6] +synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" RELATED [EC:1.3.3.6] +synonym: "fatty acyl-CoA oxidase activity" RELATED [EC:1.3.3.6] +synonym: "fatty acyl-coenzyme A oxidase activity" RELATED [EC:1.3.3.6] +xref: EC:1.3.3.6 +xref: MetaCyc:ACYL-COA-OXIDASE-RXN +xref: Reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)" +xref: Reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" +xref: Reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA" +xref: Reactome:R-HSA-390256 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2" +xref: RHEA:38959 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0003998 +name: acylphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] +synonym: "1,3-diphosphoglycerate phosphatase activity" RELATED [EC:3.6.1.7] +synonym: "acetic phosphatase activity" RELATED [EC:3.6.1.7] +synonym: "acetylphosphatase activity" RELATED [EC:3.6.1.7] +synonym: "acylphosphate phosphohydrolase activity" RELATED [EC:3.6.1.7] +synonym: "GP 1-3" RELATED [EC:3.6.1.7] +synonym: "Ho 1-3" RELATED [EC:3.6.1.7] +xref: EC:3.6.1.7 +xref: MetaCyc:ACYLPHOSPHATASE-RXN +xref: RHEA:14965 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0003999 +name: adenine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] +synonym: "adenine phosphoribosylpyrophosphate transferase activity" RELATED [EC:2.4.2.7] +synonym: "adenosine phosphoribosyltransferase activity" RELATED [EC:2.4.2.7] +synonym: "adenylate pyrophosphorylase activity" RELATED [EC:2.4.2.7] +synonym: "adenylic pyrophosphorylase activity" RELATED [EC:2.4.2.7] +synonym: "AMP diphosphorylase activity" RELATED [EC:2.4.2.7] +synonym: "AMP pyrophosphorylase activity" RELATED [EC:2.4.2.7] +synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.7] +synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.7] +synonym: "APRT activity" RELATED [EC:2.4.2.7] +synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] +xref: EC:2.4.2.7 +xref: MetaCyc:ADENPRIBOSYLTRAN-RXN +xref: Reactome:R-HSA-74213 "Adenine + PRPP => AMP + PPi" +xref: RHEA:16609 +is_a: GO:0106130 ! purine phosphoribosyltransferase activity + +[Term] +id: GO:0004000 +name: adenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] +synonym: "adenosine aminohydrolase activity" RELATED [EC:3.5.4.4] +synonym: "adenosine deaminase reaction" EXACT [] +xref: EC:3.5.4.4 +xref: MetaCyc:ADENODEAMIN-RXN +xref: Reactome:R-HSA-2161187 "N6-methyl-AMP + H2O => IMP + methylamine" +xref: Reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine" +xref: Reactome:R-HSA-5693346 "CECRI deaminates Ade-Rib to Ino" +xref: Reactome:R-HSA-74241 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)" +xref: RHEA:24408 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004001 +name: adenosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] +synonym: "adenosine 5-phosphotransferase activity" EXACT [] +synonym: "adenosine kinase (phosphorylating)" RELATED [EC:2.7.1.20] +synonym: "ATP:adenosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.20] +xref: EC:2.7.1.20 +xref: MetaCyc:ADENOSINE-KINASE-RXN +xref: Reactome:R-HSA-109624 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)" +xref: RHEA:20824 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0004005 +name: obsolete plasma membrane cation-transporting ATPase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "plasma membrane cation-transporting ATPase" EXACT [] +is_obsolete: true +consider: GO:0005886 +consider: GO:0019829 + +[Term] +id: GO:0004007 +name: obsolete heavy metal-exporting ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "heavy metal-exporting ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046873 + +[Term] +id: GO:0004009 +name: obsolete ATP-binding cassette (ABC) transporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0004013 +name: adenosylhomocysteinase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] +subset: goslim_chembl +synonym: "adenosylhomocysteine hydrolase activity" RELATED [EC:3.3.1.1] +synonym: "AdoHcyase activity" RELATED [EC:3.3.1.1] +synonym: "S-adenosyl-L-homocysteine hydrolase activity" RELATED [EC:3.3.1.1] +synonym: "S-adenosylhomocysteinase activity" RELATED [EC:3.3.1.1] +synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] +synonym: "S-adenosylhomocysteine synthase activity" RELATED [EC:3.3.1.1] +synonym: "SAHase activity" RELATED [EC:3.3.1.1] +xref: EC:3.3.1.1 +xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN +xref: Reactome:R-HSA-174401 "AHCY:NAD+ tetramer hydrolyses AdoHcy" +xref: Reactome:R-HSA-5579084 "Defective AHCY does not hydrolyse AdoHcy" +xref: RHEA:21708 +is_a: GO:0016802 ! trialkylsulfonium hydrolase activity + +[Term] +id: GO:0004014 +name: adenosylmethionine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15981] +synonym: "adenosyl methionine decarboxylase activity" EXACT [] +synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] +synonym: "S-adenosyl-L-methionine carboxy-lyase activity" RELATED [EC:4.1.1.50] +synonym: "S-adenosyl-L-methionine decarboxylase activity" RELATED [EC:4.1.1.50] +synonym: "S-adenosylmethionine decarboxylase activity" RELATED [EC:4.1.1.50] +xref: EC:4.1.1.50 +xref: KEGG_REACTION:R00178 +xref: MetaCyc:SAMDECARB-RXN +xref: Reactome:R-HSA-351222 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2" +xref: RHEA:15981 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004015 +name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16861] +synonym: "7,8-diamino-pelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "7,8-diaminonanoate transaminase activity" RELATED [EC:2.6.1.62] +synonym: "7,8-diaminononanoate aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "7,8-diaminononanoate transaminase activity" RELATED [EC:2.6.1.62] +synonym: "7,8-diaminopelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] +synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] +synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] +synonym: "DAPA aminotransferase activity" RELATED [EC:2.6.1.62] +synonym: "DAPA transaminase activity" RELATED [EC:2.6.1.62] +synonym: "diaminopelargonate synthase activity" RELATED [EC:2.6.1.62] +synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" RELATED [EC:2.6.1.62] +xref: EC:2.6.1.62 +xref: KEGG_REACTION:R03231 +xref: MetaCyc:DAPASYN-RXN +xref: RHEA:16861 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004016 +name: adenylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] +synonym: "3',5'-cyclic AMP synthetase activity" RELATED [EC:4.6.1.1] +synonym: "adenyl cyclase activity" RELATED [EC:4.6.1.1] +synonym: "adenylyl cyclase activity" EXACT [] +synonym: "adenylylcyclase activity" RELATED [EC:4.6.1.1] +synonym: "ATP diphosphate-lyase (cyclizing) activity" RELATED [EC:4.6.1.1] +synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" RELATED [EC:4.6.1.1] +synonym: "ATP pyrophosphate-lyase activity" RELATED [EC:4.6.1.1] +synonym: "cAMP generating peptide activity" RELATED [] +xref: EC:4.6.1.1 +xref: MetaCyc:ADENYLATECYC-RXN +xref: Reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis" +xref: Reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP" +xref: Reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP" +xref: Reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate" +xref: Reactome:R-HSA-5211224 "Anthrax cya catalyzes the conversion of ATP to cAMP" +xref: Reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner" +xref: RHEA:15389 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004017 +name: adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] +synonym: "5'-AMP-kinase activity" RELATED [EC:2.7.4.3] +synonym: "adenylic kinase activity" RELATED [EC:2.7.4.3] +synonym: "adenylokinase activity" RELATED [EC:2.7.4.3] +synonym: "ATP:AMP phosphotransferase activity" RELATED [EC:2.7.4.3] +synonym: "myokinase activity" NARROW [EC:2.7.4.3] +xref: EC:2.7.4.3 +xref: MetaCyc:ADENYL-KIN-RXN +xref: Reactome:R-HSA-110141 "(d)ADP + ADP <=> (d)AMP + ATP (AK1)" +xref: Reactome:R-HSA-110144 "ADP + ADP <=> AMP + ATP [AK2]" +xref: Reactome:R-HSA-110145 "AMP + ATP <=> ADP + ADP [AK2]" +xref: Reactome:R-HSA-74220 "(d)AMP + ATP <=> (d)ADP + ADP (AK1)" +xref: RHEA:12973 +is_a: GO:0050145 ! nucleoside monophosphate kinase activity + +[Term] +id: GO:0004018 +name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] +synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" RELATED [EC:4.3.2.2] +synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] +synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] +synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" RELATED [EC:4.3.2.2] +synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] +xref: EC:4.3.2.2 +xref: KEGG_REACTION:R01083 +xref: MetaCyc:AMPSYN-RXN +xref: Reactome:R-HSA-73800 "SAICAR => AICAR + Fumarate" +xref: Reactome:R-HSA-73828 "adenylosuccinate => adenosine 5'-monophosphate + fumarate" +xref: RHEA:16853 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0004019 +name: adenylosuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15753] +synonym: "adenylosuccinate synthetase activity" RELATED [EC:6.3.4.4] +synonym: "IMP--aspartate ligase activity" RELATED [EC:6.3.4.4] +synonym: "IMP:L-aspartate ligase (GDP-forming)" RELATED [EC:6.3.4.4] +synonym: "succino-AMP synthetase activity" RELATED [EC:6.3.4.4] +synonym: "succinoadenylic kinosynthetase activity" RELATED [EC:6.3.4.4] +xref: EC:6.3.4.4 +xref: KEGG_REACTION:R01135 +xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN +xref: Reactome:R-HSA-111524 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]" +xref: RHEA:15753 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004020 +name: adenylylsulfate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] +synonym: "5'-phosphoadenosine sulfate kinase activity" RELATED [EC:2.7.1.25] +synonym: "adenosine 5'-phosphosulfate kinase activity" RELATED [EC:2.7.1.25] +synonym: "adenosine phosphosulfate kinase activity" RELATED [EC:2.7.1.25] +synonym: "adenosine phosphosulfokinase activity" RELATED [EC:2.7.1.25] +synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] +synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" RELATED [EC:2.7.1.25] +synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] +synonym: "adenylyl-sulfate kinase activity" EXACT [] +synonym: "adenylyl-sulphate kinase activity" EXACT [] +synonym: "adenylylsulfate kinase (phosphorylating)" RELATED [EC:2.7.1.25] +synonym: "APS kinase activity" RELATED [EC:2.7.1.25] +synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" RELATED [EC:2.7.1.25] +xref: EC:2.7.1.25 +xref: MetaCyc:ADENYLYLSULFKIN-RXN +xref: Reactome:R-HSA-174389 "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS" +xref: Reactome:R-HSA-3560785 "Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS" +xref: RHEA:24152 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004021 +name: L-alanine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19453] +synonym: "alanine aminotransferase activity" BROAD [] +synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] +synonym: "alanine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.2] +synonym: "alanine-pyruvate aminotransferase activity" RELATED [EC:2.6.1.2] +synonym: "ALT" RELATED [EC:2.6.1.2] +synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] +synonym: "glutamic acid-pyruvic acid transaminase activity" RELATED [EC:2.6.1.2] +synonym: "glutamic--alanine transaminase activity" RELATED [EC:2.6.1.2] +synonym: "glutamic--pyruvic transaminase activity" RELATED [EC:2.6.1.2] +synonym: "glutamic-pyruvic aminotransferase activity" RELATED [EC:2.6.1.2] +synonym: "GPT" RELATED [EC:2.6.1.2] +synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] +synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] +synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.2] +synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] +synonym: "pyruvate-alanine aminotransferase activity" RELATED [EC:2.6.1.2] +synonym: "pyruvate-glutamate transaminase activity" RELATED [EC:2.6.1.2] +xref: EC:2.6.1.2 +xref: KEGG_REACTION:R00258 +xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-507749 "PXLP-K341-GPT2 transaminates PYR to form L-Ala" +xref: Reactome:R-HSA-507775 "PXLP-K341-GPT2 transaminates L-Ala to form PYR" +xref: Reactome:R-HSA-70523 "PXLP-K314-GPT transaminates L-Ala to form PYR" +xref: Reactome:R-HSA-70524 "PXLP-K314-GPT transaminates PYR to form L-Ala" +xref: RHEA:19453 +is_a: GO:0047635 ! alanine-oxo-acid transaminase activity + +[Term] +id: GO:0004022 +name: alcohol dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] +synonym: "ADH" RELATED [EC:1.1.1.1] +synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] +synonym: "alcohol:NAD+ oxidoreductase" RELATED [EC:1.1.1.1] +synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] +synonym: "aldo-keto reductase (NAD) activity" EXACT [] +synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] +synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] +synonym: "NAD-dependent alcohol dehydrogenase" RELATED [EC:1.1.1.1] +synonym: "NAD-specific aromatic alcohol dehydrogenase" RELATED [EC:1.1.1.1] +synonym: "NADH-alcohol dehydrogenase" RELATED [EC:1.1.1.1] +synonym: "NADH-aldehyde dehydrogenase" RELATED [EC:1.1.1.1] +synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] +synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] +xref: EC:1.1.1.1 +xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN +xref: Reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+" +xref: RHEA:10740 +xref: UM-BBD_enzymeID:e0023 +is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004023 +name: alcohol dehydrogenase activity, metal ion-independent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0004024 +name: alcohol dehydrogenase activity, zinc-dependent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] +xref: Reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+" +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0004025 +name: alcohol dehydrogenase activity, iron-dependent +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0004026 +name: alcohol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] +synonym: "AATASE activity" RELATED [EC:2.3.1.84] +synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" RELATED [EC:2.3.1.84] +synonym: "alcohol acetyltransferase activity" RELATED [EC:2.3.1.84] +xref: EC:2.3.1.84 +xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN +xref: RHEA:17229 +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity + +[Term] +id: GO:0004027 +name: alcohol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] +subset: goslim_chembl +synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "3-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "3beta-hydroxy steroid sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "3beta-hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "5alpha-androstenol sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "alcohol sulphotransferase activity" EXACT [] +synonym: "alcohol/hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "dehydroepiandrosterone sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" RELATED [EC:2.8.2.2] +synonym: "estrogen sulfokinase activity" RELATED [EC:2.8.2.2] +synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] +synonym: "HST" RELATED [EC:2.8.2.2] +synonym: "hydroxysteroid sulfotransferase activity" RELATED [EC:2.8.2.2] +synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] +synonym: "steroid sulfokinase activity" RELATED [EC:2.8.2.2] +synonym: "sterol sulfokinase activity" RELATED [EC:2.8.2.2] +synonym: "sterol sulfotransferase activity" RELATED [EC:2.8.2.2] +xref: EC:2.8.2.2 +xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL" +xref: Reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP" +xref: RHEA:22552 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004028 +name: 3-chloroallyl aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] +xref: Reactome:R-HSA-71260 "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT" +xref: UM-BBD_enzymeID:e0432 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004029 +name: aldehyde dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] +synonym: "aldehyde dehydrogenase (NAD+)" RELATED [EC:1.2.1.3] +synonym: "aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.3] +synonym: "CoA-independent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "m-methylbenzaldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "NAD-aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "NAD-dependent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "NAD-linked aldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +synonym: "propionaldehyde dehydrogenase activity" RELATED [EC:1.2.1.3] +xref: EC:1.2.1.3 +xref: MetaCyc:ALDHDEHYDROG-RXN +xref: Reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid" +xref: Reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate" +xref: Reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM" +xref: Reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH" +xref: Reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG" +xref: Reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG" +xref: Reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA" +xref: Reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]" +xref: Reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]" +xref: RHEA:16185 +xref: UM-BBD_enzymeID:e0024 +xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) +is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004030 +name: aldehyde dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] +synonym: "aldehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.5] +synonym: "ALDH" RELATED [EC:1.2.1.5] +xref: EC:1.2.1.5 +xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: Reactome:R-HSA-5692283 "ALD3A1 oxidises 4HPCP to CXPA" +xref: Reactome:R-HSA-5696080 "ALDH3B1 oxidises HXAL to PALM" +xref: Reactome:R-HSA-6808464 "ALDH3B2 oxidises HXAL to PALM" +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004031 +name: aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] +synonym: "aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.1] +synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] +xref: EC:1.2.3.1 +xref: MetaCyc:ALDEHYDE-OXIDASE-RXN +xref: Reactome:R-HSA-3204311 "AOX1 oxidises PXL to PDXate" +xref: RHEA:16829 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0004032 +name: alditol:NADP+ 1-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] +synonym: "aldehyde reductase activity" RELATED [EC:1.1.1.21] +synonym: "aldose reductase activity" RELATED [EC:1.1.1.21] +synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] +xref: EC:1.1.1.21 +xref: KEGG_REACTION:R02820 +xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN +xref: Reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol" +xref: Reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol" +xref: RHEA:12789 +is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity + +[Term] +id: GO:0004033 +name: aldo-keto reductase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] +synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] +synonym: "aldo-keto reductase (NADP+) activity" EXACT [] +synonym: "aldo-keto reductase activity" EXACT [] +synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] +xref: Reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one" +xref: Reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol" +xref: Reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one" +xref: Reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol" +xref: Reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one" +xref: Reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one" +xref: Reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol" +xref: Reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol" +xref: Reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol" +xref: Reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one" +xref: Reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one" +xref: Reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol" +xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-" +xref: Reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL" +xref: Reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH" +xref: Reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione" +xref: Reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA" +xref: Reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA" +xref: Reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3" +xref: Reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004034 +name: aldose 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] +synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] +synonym: "mutarotase activity" RELATED [EC:5.1.3.3] +xref: EC:5.1.3.3 +xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN +xref: RHEA:10264 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0004035 +name: alkaline phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] +synonym: "alkaline phenyl phosphatase activity" RELATED [EC:3.1.3.1] +synonym: "alkaline phosphohydrolase activity" RELATED [EC:3.1.3.1] +synonym: "alkaline phosphomonoesterase activity" RELATED [EC:3.1.3.1] +synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] +synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" RELATED [EC:3.1.3.1] +synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" RELATED [EC:3.1.3.1] +synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] +xref: EC:3.1.3.1 +xref: MetaCyc:ALKAPHOSPHA-RXN +xref: Reactome:R-HSA-8878787 "ALPI dimer hydrolyses phosphate monoesters" +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004037 +name: allantoicase activity +namespace: molecular_function +def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11016] +synonym: "allantoate amidinohydrolase activity" RELATED [EC:3.5.3.4] +synonym: "allantoine amidinohydrolase activity" EXACT [] +xref: EC:3.5.3.4 +xref: KEGG_REACTION:R02422 +xref: MetaCyc:ALLANTOICASE-RXN +xref: RHEA:11016 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004038 +name: allantoinase activity +namespace: molecular_function +def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] +synonym: "(S)-allantoin amidohydrolase activity" RELATED [EC:3.5.2.5] +xref: EC:3.5.2.5 +xref: MetaCyc:ALLANTOINASE-RXN +xref: RHEA:17029 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004039 +name: allophanate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19029] +synonym: "allophanate lyase activity" RELATED [EC:3.5.1.54] +synonym: "urea-1-carboxylate amidohydrolase activity" RELATED [EC:3.5.1.54] +xref: EC:3.5.1.54 +xref: KEGG_REACTION:R00005 +xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN +xref: RHEA:19029 +xref: UM-BBD_reactionID:r0848 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004040 +name: amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] +synonym: "acetamidase activity" EXACT [] +synonym: "acylamidase activity" RELATED [EC:3.5.1.4] +synonym: "acylamide amidohydrolase activity" RELATED [EC:3.5.1.4] +synonym: "acylase activity" RELATED [EC:3.5.1.4] +synonym: "amidohydrolase activity" RELATED [EC:3.5.1.4] +synonym: "fatty acylamidase activity" RELATED [EC:3.5.1.4] +synonym: "N-acetylaminohydrolase activity" RELATED [EC:3.5.1.4] +xref: EC:3.5.1.4 +xref: MetaCyc:AMIDASE-RXN +xref: RHEA:12020 +xref: UM-BBD_enzymeID:e0068 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004042 +name: acetyl-CoA:L-glutamate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24292] +synonym: "acetylglutamate acetylglutamate synthetase activity" RELATED [EC:2.3.1.1] +synonym: "AGAS" RELATED [EC:2.3.1.1] +synonym: "amino acid acetyltransferase activity" RELATED [EC:2.3.1.1] +synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] +synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] +xref: EC:2.3.1.1 +xref: KEGG_REACTION:R00259 +xref: MetaCyc:N-ACETYLTRANSFER-RXN +xref: Reactome:R-HSA-70542 "glutamate + acetyl CoA => N-acetyl glutamate + CoA" +xref: RHEA:24292 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004043 +name: L-aminoadipate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] +synonym: "2-aminoadipate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31] +synonym: "2-aminoadipic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31] +synonym: "AAR" RELATED [EC:1.2.1.31] +synonym: "alpha-aminoadipate reductase activity" RELATED [EC:1.2.1.31] +synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31] +synonym: "aminoadipate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31] +synonym: "aminoadipate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.31] +synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" RELATED [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" RELATED [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" RELATED [EC:1.2.1.31] +synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" RELATED [EC:1.2.1.31] +xref: EC:1.2.1.31 +xref: MetaCyc:1.2.1.31-RXN +xref: Reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+" +xref: RHEA:12308 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004044 +name: amidophosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14905] +synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" RELATED [EC:2.4.2.14] +synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "phosphoribose pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "phosphoribosyl pyrophosphate amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" RELATED [EC:2.4.2.14] +synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" RELATED [EC:2.4.2.14] +xref: EC:2.4.2.14 +xref: KEGG_REACTION:R01072 +xref: MetaCyc:PRPPAMIDOTRANS-RXN +xref: Reactome:R-HSA-73815 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate" +xref: RHEA:14905 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004045 +name: aminoacyl-tRNA hydrolase activity +namespace: molecular_function +alt_id: GO:0019850 +alt_id: GO:0019851 +def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] +synonym: "aminoacyl-transfer ribonucleate hydrolase activity" RELATED [EC:3.1.1.29] +synonym: "aminoacyl-tRNA aminoacylhydrolase activity" RELATED [EC:3.1.1.29] +synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] +synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] +synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" RELATED [EC:3.1.1.29] +synonym: "peptidyl-tRNA hydrolase activity" RELATED [EC:3.1.1.29] +xref: EC:3.1.1.29 +xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN +xref: RHEA:54448 +is_a: GO:0052689 ! carboxylic ester hydrolase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0004046 +name: aminoacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] +synonym: "acylase I activity" NARROW [EC:3.5.1.14] +synonym: "alpha-N-acylaminoacid hydrolase activity" RELATED [EC:3.5.1.14] +synonym: "amido acid deacylase activity" RELATED [EC:3.5.1.14] +synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] +synonym: "benzamidase activity" RELATED [EC:3.5.1.14] +synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] +synonym: "hippurase activity" RELATED [EC:3.5.1.14] +synonym: "histozyme activity" RELATED [EC:3.5.1.14] +synonym: "L-amino-acid acylase activity" RELATED [EC:3.5.1.14] +synonym: "L-aminoacylase activity" RELATED [EC:3.5.1.14] +synonym: "long acyl amidoacylase activity" RELATED [EC:3.5.1.14] +synonym: "N-acyl-L-amino-acid amidohydrolase activity" RELATED [EC:3.5.1.14] +synonym: "short acyl amidoacylase activity" RELATED [EC:3.5.1.14] +xref: EC:3.5.1.14 +xref: MetaCyc:AMINOACYLASE-RXN +xref: Reactome:R-HSA-5433074 "ACY1:Zn2+ dimer hydrolyses mercapturic acids" +xref: Reactome:R-HSA-5579081 "Defective ACY1 does not hydrolyse mercapturic acids" +xref: Reactome:R-HSA-9638046 "ACY3:Zn2+ dimer hydrolyses mercapturic acids" +xref: RHEA:15565 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004047 +name: aminomethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] +synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] +synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] +synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10] +synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10] +synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" RELATED [EC:2.1.2.10] +synonym: "T-protein" RELATED [EC:2.1.2.10] +synonym: "tetrahydrofolate aminomethyltransferase activity" RELATED [EC:2.1.2.10] +xref: EC:2.1.2.10 +xref: MetaCyc:GCVT-RXN +xref: Reactome:R-HSA-5693977 "AMT transfers NH2CH2 from GCSH:SAMDLL to THF" +xref: RHEA:16945 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0004048 +name: anthranilate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11768] +synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.18] +synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.18] +synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" RELATED [EC:2.4.2.18] +synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.18] +synonym: "phosphoribosyl-anthranilate diphosphorylase activity" RELATED [EC:2.4.2.18] +synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" RELATED [EC:2.4.2.18] +synonym: "phosphoribosylanthranilate pyrophosphorylase activity" RELATED [EC:2.4.2.18] +synonym: "phosphoribosylanthranilate transferase activity" RELATED [EC:2.4.2.18] +synonym: "PRT" RELATED [EC:2.4.2.18] +xref: EC:2.4.2.18 +xref: KEGG_REACTION:R01073 +xref: MetaCyc:PRTRANS-RXN +xref: RHEA:11768 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004049 +name: anthranilate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] +synonym: "anthranilate synthetase activity" RELATED [EC:4.1.3.27] +synonym: "chorismate pyruvate-lyase (amino-accepting) activity" RELATED [EC:4.1.3.27] +xref: EC:4.1.3.27 +xref: MetaCyc:ANTHRANSYN-RXN +xref: RHEA:21732 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004050 +name: obsolete apyrase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] +comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. +synonym: "apyrase activity" EXACT [] +is_obsolete: true +consider: GO:0017110 +consider: GO:0017111 + +[Term] +id: GO:0004051 +name: arachidonate 5-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34, RHEA:32307] +synonym: "5-delta-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "5Delta-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "arachidonate:oxygen 5-oxidoreductase activity" RELATED [EC:1.13.11.34] +synonym: "arachidonic 5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "arachidonic acid 5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "delta5-lipoxygenase activity" RELATED [EC:1.13.11.34] +synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] +synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] +synonym: "leukotriene-A4 synthase activity" RELATED [EC:1.13.11.34] +synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] +xref: EC:1.13.11.34 +xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN +xref: Reactome:R-HSA-265296 "Arachidonic acid is oxidised to 5S-HpETE by ALOX5" +xref: Reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5" +xref: Reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE" +xref: Reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE" +xref: Reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE" +xref: Reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE" +xref: Reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA" +xref: Reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA" +xref: Reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA" +xref: Reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA" +xref: Reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA" +xref: Reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA" +xref: Reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA" +xref: Reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA" +xref: Reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA" +xref: Reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3" +xref: Reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3" +xref: Reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3" +xref: Reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA" +xref: Reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4" +xref: Reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA" +xref: Reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE" +xref: Reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3" +xref: RHEA:32307 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004052 +name: arachidonate 12(S)-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10428] +synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "12Delta-lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "12S-lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "arachidonate:oxygen 12-oxidoreductase activity" RELATED [EC:1.13.11.31] +synonym: "C-12 lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "delta12-lipoxygenase activity" RELATED [EC:1.13.11.31] +synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] +synonym: "LTA4 synthase activity" RELATED [EC:1.13.11.31] +xref: EC:1.13.11.31 +xref: KEGG_REACTION:R01596 +xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN +xref: Reactome:R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12" +xref: Reactome:R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B" +xref: Reactome:R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15" +xref: Reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA" +xref: Reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6" +xref: Reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3" +xref: Reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3" +xref: RHEA:10428 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004053 +name: arginase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] +synonym: "arginine amidinase activity" RELATED [EC:3.5.3.1] +synonym: "arginine transamidinase activity" RELATED [EC:3.5.3.1] +synonym: "canavanase activity" RELATED [EC:3.5.3.1] +synonym: "L-arginase activity" RELATED [EC:3.5.3.1] +synonym: "L-arginine amidinohydrolase activity" RELATED [EC:3.5.3.1] +xref: EC:3.5.3.1 +xref: MetaCyc:ARGINASE-RXN +xref: Reactome:R-HSA-452036 "arginine + H2O => ornithine + urea [ARG2]" +xref: Reactome:R-HSA-70569 "arginine + H2O => ornithine + urea [ARG1]" +xref: RHEA:20569 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004054 +name: arginine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22940] +synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" RELATED [EC:2.7.3.3] +synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] +synonym: "arginine phosphokinase activity" RELATED [EC:2.7.3.3] +synonym: "ATP:L-arginine N-phosphotransferase activity" RELATED [EC:2.7.3.3] +xref: EC:2.7.3.3 +xref: KEGG_REACTION:R00554 +xref: MetaCyc:ARGININE-KINASE-RXN +xref: RHEA:22940 +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004055 +name: argininosuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] +synonym: "arginine succinate synthetase activity" RELATED [EC:6.3.4.5] +synonym: "argininosuccinate synthetase activity" RELATED [EC:6.3.4.5] +synonym: "argininosuccinic acid synthetase activity" RELATED [EC:6.3.4.5] +synonym: "arginosuccinate synthetase activity" RELATED [EC:6.3.4.5] +synonym: "citrulline--aspartate ligase activity" RELATED [EC:6.3.4.5] +synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" RELATED [EC:6.3.4.5] +xref: EC:6.3.4.5 +xref: MetaCyc:ARGSUCCINSYN-RXN +xref: Reactome:R-HSA-70577 "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA" +xref: RHEA:10932 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004056 +name: argininosuccinate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] +synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" RELATED [EC:4.3.2.1] +synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" RELATED [EC:4.3.2.1] +synonym: "arginine-succinate lyase activity" RELATED [EC:4.3.2.1] +synonym: "argininosuccinic acid lyase activity" RELATED [EC:4.3.2.1] +synonym: "arginosuccinase activity" RELATED [EC:4.3.2.1] +synonym: "N-(L-argininosuccinate) arginine-lyase activity" RELATED [EC:4.3.2.1] +synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" RELATED [EC:4.3.2.1] +xref: EC:4.3.2.1 +xref: MetaCyc:ARGSUCCINLYA-RXN +xref: Reactome:R-HSA-70573 "argininosuccinate <=> fumarate + arginine" +xref: RHEA:24020 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0004057 +name: arginyltransferase activity +namespace: molecular_function +alt_id: GO:0042172 +def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] +synonym: "arginine transferase activity" RELATED [EC:2.3.2.8] +synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" RELATED [EC:2.3.2.8] +synonym: "arginyl-transfer ribonucleate-protein transferase activity" RELATED [EC:2.3.2.8] +synonym: "arginyl-tRNA protein transferase activity" RELATED [EC:2.3.2.8] +synonym: "arginyl-tRNA--protein transferase activity" RELATED [EC:2.3.2.8] +synonym: "arginyl-tRNA-protein transferase activity" EXACT [] +synonym: "L-arginyl-tRNA:protein arginyltransferase activity" RELATED [EC:2.3.2.8] +xref: EC:2.3.2.8 +xref: MetaCyc:ARGINYLTRANSFERASE-RXN +xref: RHEA:10208 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0004058 +name: aromatic-L-amino-acid decarboxylase activity +namespace: molecular_function +alt_id: GO:0016400 +def: "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28] +synonym: "5-hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] +synonym: "aromatic amino acid decarboxylase activity" RELATED [EC:4.1.1.28] +synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" NARROW [EC:4.1.1.28] +synonym: "aromatic-L-amino-acid carboxy-lyase activity" RELATED [EC:4.1.1.28] +synonym: "DOPA decarboxylase activity" NARROW [EC:4.1.1.28] +synonym: "hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] +synonym: "L-DOPA decarboxylase activity" NARROW [EC:4.1.1.28] +synonym: "tryptophan decarboxylase activity" NARROW [EC:4.1.1.28] +xref: EC:4.1.1.28 +xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-209859 "Decarboxylation of 5-hydroxytryptophan forms serotonin" +xref: Reactome:R-HSA-209924 "Dopa is decarboxylated to dopamine" +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004059 +name: aralkylamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] +synonym: "AANAT activity" RELATED [EC:2.3.1.87] +synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" RELATED [EC:2.3.1.87] +synonym: "arylalkylamine N-acetyltransferase activity" RELATED [EC:2.3.1.87] +synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] +synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] +synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] +synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] +xref: EC:2.3.1.87 +xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-209792 "N-acetylation of serotonin" +xref: RHEA:20497 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004060 +name: arylamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] +synonym: "2-naphthylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "4-aminobiphenyl N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "acetyl CoA-arylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "arylamine acetylase activity" RELATED [EC:2.3.1.5] +synonym: "arylamine acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "beta-naphthylamine N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "indoleamine N-acetyltransferase activity" RELATED [EC:2.3.1.5] +synonym: "p-aminosalicylate N-acetyltransferase activity" RELATED [EC:2.3.1.5] +xref: EC:2.3.1.5 +xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-174963 "NAT1 acetylation" +xref: Reactome:R-HSA-174967 "NAT2 acetylation" +xref: RHEA:16613 +xref: UM-BBD_enzymeID:e0341 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004061 +name: arylformamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] +synonym: "aryl-formylamine amidohydrolase activity" RELATED [EC:3.5.1.9] +synonym: "formamidase I" RELATED [EC:3.5.1.9] +synonym: "formamidase II" RELATED [EC:3.5.1.9] +synonym: "formylase activity" RELATED [EC:3.5.1.9] +synonym: "formylkynureninase activity" RELATED [EC:3.5.1.9] +synonym: "formylkynurenine formamidase activity" RELATED [EC:3.5.1.9] +synonym: "kynurenine formamidase activity" RELATED [EC:3.5.1.9] +xref: EC:3.5.1.9 +xref: MetaCyc:ARYLFORMAMIDASE-RXN +xref: Reactome:R-HSA-71189 "AFMID hydrolyses NFK to L-KYN" +xref: RHEA:13009 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004062 +name: aryl sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] +subset: goslim_chembl +synonym: "1-naphthol phenol sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "2-naphtholsulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "4-nitrocatechol sulfokinase activity" RELATED [EC:2.8.2.1] +synonym: "aryl sulphotransferase activity" EXACT [] +synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] +synonym: "dopamine sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "p-nitrophenol sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "phenol sulfokinase activity" RELATED [EC:2.8.2.1] +synonym: "phenol sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "PST" RELATED [EC:2.8.2.1] +synonym: "ritodrine sulfotransferase activity" RELATED [EC:2.8.2.1] +synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] +xref: EC:2.8.2.1 +xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-158468 "SULT1A1 dimer sulfonates PARA to PARA-SO4" +xref: Reactome:R-HSA-158849 "Phenol can form a sulfate conjugate" +xref: Reactome:R-HSA-158860 "SULT1A1 dimer sulfonates NHABP" +xref: Reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS" +xref: Reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP" +xref: Reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP" +xref: Reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP" +xref: RHEA:12164 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004063 +name: aryldialkylphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] +synonym: "A-esterase activity" BROAD [EC:3.1.8.1] +synonym: "aryltriphosphatase activity" RELATED [EC:3.1.8.1] +synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [] +synonym: "esterase B1" RELATED [EC:3.1.8.1] +synonym: "esterase E4" RELATED [EC:3.1.8.1] +synonym: "OPH" RELATED [EC:3.1.8.1] +synonym: "organophosphate esterase activity" BROAD [] +synonym: "organophosphate hydrolase activity" BROAD [] +synonym: "organophosphorus acid anhydrase activity" BROAD [] +synonym: "organophosphorus hydrolase activity" BROAD [] +synonym: "paraoxon esterase activity" NARROW [] +synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] +synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] +synonym: "phosphotriesterase activity" NARROW [EC:3.1.8.1] +synonym: "pirimiphos-methyloxon esterase activity" NARROW [] +xref: EC:3.1.8.1 +xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN +xref: RHEA:18053 +xref: UM-BBD_enzymeID:e0054 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004064 +name: arylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] +synonym: "A-esterase activity" BROAD [EC:3.1.1.2] +synonym: "aromatic esterase" NARROW [EC:3.1.1.2] +synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] +synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] +xref: EC:3.1.1.2 +xref: MetaCyc:ARYLESTERASE-RXN +xref: RHEA:17309 +xref: UM-BBD_reactionID:r0757 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004065 +name: arylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1] +synonym: "4-methylumbelliferyl sulfatase activity" RELATED [EC:3.1.6.1] +synonym: "aryl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.1] +synonym: "aryl-sulfate sulphohydrolase activity" RELATED [EC:3.1.6.1] +synonym: "aryl-sulphate sulphohydrolase activity" RELATED [EC:3.1.6.1] +synonym: "arylsulfohydrolase activity" RELATED [EC:3.1.6.1] +synonym: "arylsulphatase activity" EXACT [] +synonym: "estrogen sulfatase activity" RELATED [EC:3.1.6.1] +synonym: "nitrocatechol sulfatase activity" RELATED [EC:3.1.6.1] +synonym: "p-nitrophenyl sulfatase activity" RELATED [EC:3.1.6.1] +synonym: "phenolsulfatase activity" RELATED [EC:3.1.6.1] +synonym: "phenylsulfatase activity" RELATED [EC:3.1.6.1] +synonym: "sulfatase activity" RELATED [EC:3.1.6.1] +xref: EC:3.1.6.1 +xref: MetaCyc:ARYLSULFAT-RXN +xref: RHEA:17261 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004066 +name: asparagine synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4, RHEA:12228] +synonym: "AS" RELATED [EC:6.3.5.4] +synonym: "AS-B activity" RELATED [EC:6.3.5.4] +synonym: "asparagine synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.4] +synonym: "asparagine synthetase (glutamine-hydrolysing)" RELATED [EC:6.3.5.4] +synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.4] +synonym: "asparagine synthetase B activity" RELATED [EC:6.3.5.4] +synonym: "glutamine-dependent asparagine synthetase activity" RELATED [EC:6.3.5.4] +synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" RELATED [EC:6.3.5.4] +xref: EC:6.3.5.4 +xref: MetaCyc:ASNSYNB-RXN +xref: Reactome:R-HSA-70599 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]" +xref: RHEA:12228 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004067 +name: asparaginase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] +synonym: "alpha-asparaginase activity" RELATED [EC:3.5.1.1] +synonym: "asparaginase II" RELATED [EC:3.5.1.1] +synonym: "colaspase activity" RELATED [EC:3.5.1.1] +synonym: "crasnitin" RELATED [EC:3.5.1.1] +synonym: "elspar" RELATED [EC:3.5.1.1] +synonym: "L-asparaginase activity" RELATED [EC:3.5.1.1] +synonym: "L-asparagine amidohydrolase activity" RELATED [EC:3.5.1.1] +synonym: "leunase activity" RELATED [EC:3.5.1.1] +xref: EC:3.5.1.1 +xref: MetaCyc:ASPARAGHYD-RXN +xref: Reactome:R-HSA-6797627 "ASPG hydrolyses L-Asn to L-Asp" +xref: RHEA:21016 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004068 +name: aspartate 1-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "aspartate alpha-decarboxylase activity" RELATED [EC:4.1.1.11] +synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] +synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" RELATED [EC:4.1.1.11] +synonym: "L-aspartate 1-carboxy-lyase activity" RELATED [EC:4.1.1.11] +synonym: "L-aspartate alpha-decarboxylase activity" RELATED [EC:4.1.1.11] +xref: EC:4.1.1.11 +xref: MetaCyc:ASPDECARBOX-RXN +xref: MetaCyc:PWY-5155 +xref: RHEA:19497 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004069 +name: L-aspartate:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] +synonym: "2-oxoglutarate-glutamate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "AAT" RELATED [EC:2.6.1.1] +synonym: "aspartate alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.1] +synonym: "aspartate aminotransferase activity" BROAD [] +synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] +synonym: "aspartate-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.1] +synonym: "aspartate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] +synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] +synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] +synonym: "AspT" RELATED [EC:2.6.1.1] +synonym: "glutamate oxaloacetate transaminase activity" RELATED [EC:2.6.1.1] +synonym: "glutamate-oxalacetate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "glutamate-oxalate transaminase activity" RELATED [EC:2.6.1.1] +synonym: "glutamic oxalic transaminase activity" RELATED [EC:2.6.1.1] +synonym: "glutamic--aspartic transaminase activity" RELATED [EC:2.6.1.1] +synonym: "glutamic--oxaloacetic transaminase activity" RELATED [EC:2.6.1.1] +synonym: "glutamic-aspartic aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "glutamic-oxalacetic transaminase activity" RELATED [EC:2.6.1.1] +synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] +synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] +synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "L-aspartate-2-oxoglutarate-transaminase activity" RELATED [EC:2.6.1.1] +synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.1] +synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] +synonym: "oxaloacetate transferase activity" RELATED [EC:2.6.1.1] +synonym: "oxaloacetate-aspartate aminotransferase activity" RELATED [EC:2.6.1.1] +synonym: "transaminase A activity" RELATED [EC:2.6.1.1] +xref: EC:2.6.1.1 +xref: KEGG_REACTION:R00355 +xref: MetaCyc:ASPAMINOTRANS-RXN +xref: Reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]" +xref: Reactome:R-HSA-70592 "PXLP-K259-GOT1 dimer deaminates L-Asp" +xref: Reactome:R-HSA-70596 "GOT2 dimer deaminates L-Asp" +xref: Reactome:R-HSA-70613 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]" +xref: RHEA:21824 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004070 +name: aspartate carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20013] +synonym: "aspartate carbamyltransferase activity" RELATED [EC:2.1.3.2] +synonym: "aspartate transcarbamoylase activity" RELATED [EC:2.1.3.2] +synonym: "aspartate transcarbamylase activity" RELATED [EC:2.1.3.2] +synonym: "aspartic acid transcarbamoylase activity" RELATED [EC:2.1.3.2] +synonym: "aspartic carbamyltransferase activity" RELATED [EC:2.1.3.2] +synonym: "aspartic transcarbamylase activity" RELATED [EC:2.1.3.2] +synonym: "ATCase activity" RELATED [EC:2.1.3.2] +synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" RELATED [EC:2.1.3.2] +synonym: "carbamoylaspartotranskinase activity" RELATED [EC:2.1.3.2] +synonym: "carbamylaspartotranskinase activity" RELATED [EC:2.1.3.2] +synonym: "L-aspartate transcarbamoylase activity" RELATED [EC:2.1.3.2] +synonym: "L-aspartate transcarbamylase activity" RELATED [EC:2.1.3.2] +xref: EC:2.1.3.2 +xref: KEGG_REACTION:R01397 +xref: MetaCyc:ASPCARBTRANS-RXN +xref: Reactome:R-HSA-73573 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate" +xref: RHEA:20013 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0004071 +name: aspartate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] +synonym: "asparagine synthetase activity" RELATED [EC:6.3.1.1] +synonym: "L-asparagine synthetase activity" RELATED [EC:6.3.1.1] +synonym: "L-aspartate:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.1] +xref: EC:6.3.1.1 +xref: MetaCyc:ASNSYNA-RXN +xref: RHEA:11372 +is_a: GO:0016211 ! ammonia ligase activity + +[Term] +id: GO:0004072 +name: aspartate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23776] +synonym: "aspartic kinase activity" RELATED [EC:2.7.2.4] +synonym: "aspartokinase activity" RELATED [EC:2.7.2.4] +synonym: "ATP:L-aspartate 4-phosphotransferase activity" RELATED [EC:2.7.2.4] +synonym: "beta-aspartokinase activity" RELATED [EC:2.7.2.4] +xref: EC:2.7.2.4 +xref: KEGG_REACTION:R00480 +xref: MetaCyc:ASPARTATEKIN-RXN +xref: RHEA:23776 +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004073 +name: aspartate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24284] +synonym: "ASA dehydrogenase activity" RELATED [EC:1.2.1.11] +synonym: "aspartate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11] +synonym: "aspartic beta-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11] +synonym: "aspartic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11] +synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.11] +synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.11] +synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" RELATED [EC:1.2.1.11] +xref: EC:1.2.1.11 +xref: KEGG_REACTION:R02291 +xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:24284 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004074 +name: biliverdin reductase (NAD(P)+) activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] +synonym: "bilirubin:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.24] +xref: EC:1.3.1.24 +xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN +xref: Reactome:R-HSA-189384 "BLVRA:Zn2+, BLVRB reduce BV to BIL" +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004075 +name: biotin carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] +synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" RELATED [EC:6.3.4.14] +synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" RELATED [EC:6.3.4.14] +xref: EC:6.3.4.14 +xref: MetaCyc:BIOTIN-CARBOXYL-RXN +xref: RHEA:13501 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004076 +name: biotin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22060] +synonym: "biotin synthetase activity" RELATED [EC:2.8.1.6] +synonym: "dethiobiotin:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.6] +xref: EC:2.8.1.6 +xref: KEGG_REACTION:R01078 +xref: MetaCyc:2.8.1.6-RXN +xref: RHEA:22060 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0004077 +name: biotin-[acetyl-CoA-carboxylase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] +synonym: "acetyl CoA holocarboxylase synthetase activity" RELATED [EC:6.3.4.15] +synonym: "acetyl coenzyme A holocarboxylase synthetase activity" RELATED [EC:6.3.4.15] +synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" RELATED [EC:6.3.4.15] +synonym: "biotin holoenzyme synthetase activity" RELATED [EC:6.3.4.15] +synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" RELATED [EC:6.3.4.15] +synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] +synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" RELATED [EC:6.3.4.15] +synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] +synonym: "biotin-acetyl-CoA-carboxylase ligase activity" RELATED [EC:6.3.4.15] +synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" RELATED [EC:6.3.4.15] +synonym: "biotin:apocarboxylase ligase activity" RELATED [EC:6.3.4.15] +synonym: "HCS" RELATED [EC:6.3.4.15] +xref: EC:6.3.4.15 +xref: MetaCyc:BIOTINLIG-RXN +xref: RHEA:11756 +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004078 +name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] +synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" RELATED [EC:6.3.4.11] +synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" RELATED [EC:6.3.4.11] +synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" RELATED [EC:6.3.4.11] +synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" RELATED [EC:6.3.4.11] +synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] +synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" RELATED [EC:6.3.4.11] +xref: EC:6.3.4.11 +xref: MetaCyc:6.3.4.11-RXN +xref: RHEA:24376 +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004079 +name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" RELATED [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" RELATED [EC:6.3.4.9] +synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" RELATED [EC:6.3.4.9] +synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] +synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" RELATED [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" RELATED [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" RELATED [EC:6.3.4.9] +synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" RELATED [EC:6.3.4.9] +synonym: "biotin-transcarboxylase synthetase activity" RELATED [EC:6.3.4.9] +synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" RELATED [EC:6.3.4.9] +synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" RELATED [EC:6.3.4.9] +synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" RELATED [EC:6.3.4.9] +xref: EC:6.3.4.9 +xref: MetaCyc:6.3.4.9-RXN +xref: RHEA:23668 +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004080 +name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] +synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" RELATED [EC:6.3.4.10] +synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" RELATED [EC:6.3.4.10] +synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" RELATED [EC:6.3.4.10] +synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" RELATED [EC:6.3.4.10] +synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" RELATED [EC:6.3.4.10] +synonym: "holocarboxylase synthetase activity" RELATED [EC:6.3.4.10] +synonym: "propionyl coenzyme A holocarboxylase synthetase activity" RELATED [EC:6.3.4.10] +synonym: "propionyl-CoA holocarboxylase synthetase activity" RELATED [EC:6.3.4.10] +xref: EC:6.3.4.10 +xref: MetaCyc:6.3.4.10-RXN +xref: RHEA:11204 +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0004081 +name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity +namespace: molecular_function +def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] +synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.17] +synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] +synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] +synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] +synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] +synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] +synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" RELATED [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" RELATED [EC:3.6.1.17] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] +synonym: "diadenosine P1,P4-tetraphosphatase activity" RELATED [EC:3.6.1.17] +synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] +synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] +synonym: "dinucleoside tetraphosphatase activity" RELATED [EC:3.6.1.17] +synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" RELATED [EC:3.6.1.17] +synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.17] +xref: EC:3.6.1.17 +xref: MetaCyc:3.6.1.17-RXN +xref: Reactome:R-HSA-5696197 "NUDT2 hydrolyses GP4G to GTP, GMP" +xref: RHEA:22484 +is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity + +[Term] +id: GO:0004082 +name: bisphosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] +synonym: "2,3-bisphosphoglycerate mutase activity" RELATED [EC:5.4.2.4] +synonym: "2,3-bisphosphoglycerate synthase activity" RELATED [EC:5.4.2.4] +synonym: "2,3-diphosphoglycerate mutase activity" RELATED [EC:5.4.2.4] +synonym: "2,3-diphosphoglycerate synthase activity" RELATED [EC:5.4.2.4] +synonym: "2,3-diphosphoglyceromutase activity" RELATED [EC:5.4.2.4] +synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" RELATED [EC:5.4.2.4] +synonym: "biphosphoglycerate synthase activity" RELATED [EC:5.4.2.4] +synonym: "bisphosphoglycerate synthase activity" RELATED [EC:5.4.2.4] +synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] +synonym: "BPGM activity" RELATED [EC:5.4.2.4] +synonym: "diphosphoglycerate mutase activity" RELATED [EC:5.4.2.4] +synonym: "diphosphoglyceric mutase activity" RELATED [EC:5.4.2.4] +synonym: "diphosphoglyceromutase activity" RELATED [EC:5.4.2.4] +synonym: "DPGM" RELATED [EC:5.4.2.4] +synonym: "glycerate phosphomutase activity" RELATED [EC:5.4.2.4] +xref: EC:5.4.2.4 +xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN +xref: Reactome:R-HSA-6798335 "BPGM dimer isomerises 1,3BPG to 2,3BPG" +xref: RHEA:17765 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004083 +name: bisphosphoglycerate 2-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [RHEA:21904] +synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" BROAD [] +xref: KEGG_REACTION:R01516 +xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN +xref: RHEA:21904 +is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity + +[Term] +id: GO:0004084 +name: branched-chain-amino-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah] +synonym: "branched-chain amino acid aminotransferase activity" EXACT [] +synonym: "branched-chain amino acid-glutamate transaminase activity" RELATED [EC:2.6.1.42] +synonym: "branched-chain aminotransferase activity" RELATED [EC:2.6.1.42] +synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.42] +synonym: "glutamate-branched-chain amino acid transaminase activity" RELATED [EC:2.6.1.42] +synonym: "L-branched chain amino acid aminotransferase activity" RELATED [EC:2.6.1.42] +synonym: "transaminase B activity" RELATED [EC:2.6.1.42] +xref: EC:2.6.1.42 +xref: Reactome:R-HSA-508179 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]" +xref: Reactome:R-HSA-508189 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]" +xref: Reactome:R-HSA-70723 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]" +xref: Reactome:R-HSA-70724 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]" +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004085 +name: butyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1] +synonym: "3-hydroxyacyl CoA reductase activity" RELATED [EC:1.3.8.1] +synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" RELATED [EC:1.3.8.1] +synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" RELATED [EC:1.3.8.1] +synonym: "butyryl coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.1] +synonym: "butyryl dehydrogenase activity" RELATED [EC:1.3.8.1] +synonym: "enoyl-coenzyme A reductase activity" RELATED [EC:1.3.8.1] +synonym: "ethylene reductase activity" RELATED [EC:1.3.8.1] +synonym: "short-chain acyl CoA dehydrogenase activity" RELATED [EC:1.3.8.1] +synonym: "short-chain acyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.1] +synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1] +synonym: "unsaturated acyl coenzyme A reductase activity" RELATED [EC:1.3.8.1] +synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1] +xref: EC:1.3.8.1 +xref: KEGG_REACTION:R01178 +xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN +xref: UM-BBD_reactionID:r0013 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0004086 +name: obsolete carbamoyl-phosphate synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] +comment: This term was made obsolete because it is a grouping term based on name, rather than on function. +synonym: "carbamoyl phosphate synthase activity" EXACT [] +synonym: "carbamoyl-phosphate synthase activity" EXACT [] +is_obsolete: true +consider: GO:0004087 +consider: GO:0004088 + +[Term] +id: GO:0004087 +name: carbamoyl-phosphate synthase (ammonia) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10624] +synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] +synonym: "carbamoyl-phosphate synthetase (ammonia) activity" RELATED [EC:6.3.4.16] +synonym: "carbamoyl-phosphate synthetase I activity" RELATED [EC:6.3.4.16] +synonym: "carbamoylphosphate synthase (ammonia)" RELATED [EC:6.3.4.16] +synonym: "carbamoylphosphate synthase activity" RELATED [EC:6.3.4.16] +synonym: "carbamoylphosphate synthetase (ammonia) activity" RELATED [EC:6.3.4.16] +synonym: "carbamylphosphate synthetase activity" RELATED [EC:6.3.4.16] +synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] +synonym: "carbmoylphosphate synthetase activity" RELATED [EC:6.3.4.16] +synonym: "carbon-dioxide--ammonia ligase activity" RELATED [EC:6.3.4.16] +synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" RELATED [EC:6.3.4.16] +synonym: "CPS I activity" NARROW [EC:6.3.4.16] +xref: EC:6.3.4.16 +xref: KEGG_REACTION:R00149 +xref: MetaCyc:6.3.4.16-RXN +xref: Reactome:R-HSA-70555 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]" +xref: RHEA:10624 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004088 +name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5, RHEA:18633] +synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] +synonym: "carbamoyl phosphate synthetase activity" RELATED [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" RELATED [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" RELATED [EC:6.3.5.5] +synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" RELATED [EC:6.3.5.5] +synonym: "carbamoylphosphate synthetase II activity" RELATED [EC:6.3.5.5] +synonym: "carbamyl phosphate synthetase (glutamine) activity" RELATED [EC:6.3.5.5] +synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED [EC:6.3.5.5] +synonym: "CPS activity" RELATED [EC:6.3.5.5] +synonym: "GD-CPSase activity" RELATED [EC:6.3.5.5] +synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" RELATED [EC:6.3.5.5] +synonym: "glutamine-dependent carbamyl phosphate synthetase activity" RELATED [EC:6.3.5.5] +synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" RELATED [EC:6.3.5.5] +xref: EC:6.3.5.5 +xref: MetaCyc:CARBPSYN-RXN +xref: Reactome:R-HSA-73577 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate" +xref: RHEA:18633 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004089 +name: carbonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] +synonym: "anhydrase activity" RELATED [EC:4.2.1.1] +synonym: "carbonate anhydrase activity" RELATED [EC:4.2.1.1] +synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" RELATED [EC:4.2.1.1] +synonym: "carbonate hydro-lyase activity" RELATED [EC:4.2.1.1] +synonym: "carbonic acid anhydrase activity" RELATED [EC:4.2.1.1] +synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] +synonym: "carbonic anhydrase activity" EXACT [] +synonym: "carbonic dehydratase activity" RELATED [EC:4.2.1.1] +synonym: "carboxyanhydrase activity" RELATED [EC:4.2.1.1] +xref: EC:4.2.1.1 +xref: MetaCyc:CARBODEHYDRAT-RXN +xref: Reactome:R-HSA-1237045 "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton" +xref: Reactome:R-HSA-1237047 "Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton" +xref: Reactome:R-HSA-1237059 "Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide" +xref: Reactome:R-HSA-1237081 "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide" +xref: Reactome:R-HSA-1475017 "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)" +xref: Reactome:R-HSA-1475022 "Carbonic anhydrase dehydrates bicarbonate (cytosol)" +xref: Reactome:R-HSA-1475025 "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)" +xref: Reactome:R-HSA-1475026 "Carbonic anhydrase hydrates carbon dioxide (cytosol)" +xref: Reactome:R-HSA-1475028 "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" +xref: Reactome:R-HSA-1475032 "Carbonic anhydrase hydrates carbon dioxide (mitochondria)" +xref: Reactome:R-HSA-1475435 "Carbonic anhydrase I/II hydrates carbon dioxide" +xref: Reactome:R-HSA-1475436 "Carbonic anhydrase I/II dehydrates bicarbonate" +xref: RHEA:10748 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004090 +name: carbonyl reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] +synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] +synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] +synonym: "ALR3" RELATED [EC:1.1.1.184] +synonym: "carbonyl reductase activity" RELATED [EC:1.1.1.184] +synonym: "NADPH-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184] +synonym: "NADPH2-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184] +synonym: "nonspecific NADPH-dependent carbonyl reductase activity" RELATED [EC:1.1.1.184] +synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] +synonym: "secondary-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.184] +synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] +xref: EC:1.1.1.184 +xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN +xref: Reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL" +xref: RHEA:19257 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004092 +name: carnitine O-acetyltransferase activity +namespace: molecular_function +alt_id: GO:0004093 +alt_id: GO:0004094 +def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21136] +synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" RELATED [EC:2.3.1.7] +synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" RELATED [EC:2.3.1.7] +synonym: "acetylcarnitine transferase activity" RELATED [EC:2.3.1.7] +synonym: "carnitine acetyl coenzyme A transferase activity" RELATED [EC:2.3.1.7] +synonym: "carnitine acetylase activity" RELATED [EC:2.3.1.7] +synonym: "carnitine acetyltransferase activity" RELATED [EC:2.3.1.7] +synonym: "carnitine O-acetyltransferase I activity" NARROW [] +synonym: "carnitine O-acetyltransferase II activity" NARROW [] +synonym: "carnitine-acetyl-CoA transferase activity" RELATED [EC:2.3.1.7] +synonym: "CATC" RELATED [EC:2.3.1.7] +xref: EC:2.3.1.7 +xref: KEGG_REACTION:R02396 +xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-390284 "propionyl-CoA + carnitine => propionylcarnitine + CoASH" +xref: Reactome:R-HSA-390291 "acetyl-CoA + carnitine => acetylcarnitine + CoASH" +xref: RHEA:21136 +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004095 +name: carnitine O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] +synonym: "acylcarnitine transferase activity" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] +synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] +synonym: "CPT" RELATED [EC:2.3.1.21] +synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] +synonym: "CPT-A" RELATED [EC:2.3.1.21] +synonym: "CPT-B" RELATED [EC:2.3.1.21] +synonym: "CPTi" RELATED [EC:2.3.1.21] +synonym: "CPTo" RELATED [EC:2.3.1.21] +synonym: "L-carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21] +synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" RELATED [EC:2.3.1.21] +synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" RELATED [EC:2.3.1.21] +synonym: "palmitoylcarnitine transferase activity" RELATED [EC:2.3.1.21] +xref: EC:2.3.1.21 +xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN +xref: Reactome:R-HSA-200406 "CPT1A,B transfers PALM to CAR" +xref: Reactome:R-HSA-200410 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine" +xref: RHEA:12661 +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016416 ! O-palmitoyltransferase activity + +[Term] +id: GO:0004096 +name: catalase activity +namespace: molecular_function +alt_id: GO:0016952 +alt_id: GO:0016953 +def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] +synonym: "bacterial catalase-peroxidase activity" NARROW [] +synonym: "caperase activity" RELATED [EC:1.11.1.6] +synonym: "CAT" RELATED [EC:1.11.1.6] +synonym: "catalase reaction" EXACT [] +synonym: "catalase-peroxidase activity" RELATED [EC:1.11.1.6] +synonym: "equilase activity" RELATED [EC:1.11.1.6] +synonym: "haem catalase activity" NARROW [] +synonym: "heme catalase activity" NARROW [] +synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.6] +synonym: "manganese catalase activity" NARROW [] +synonym: "optidase activity" RELATED [EC:1.11.1.6] +xref: EC:1.11.1.6 +xref: MetaCyc:CATAL-RXN +xref: Reactome:R-HSA-1222704 "KatG reduces H2O2" +xref: Reactome:R-HSA-76031 "2 H2O2 => O2 + 2 H2O" +xref: RHEA:20309 +xref: UM-BBD_enzymeID:e0834 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004097 +name: catechol oxidase activity +namespace: molecular_function +alt_id: GO:0036263 +alt_id: GO:0036264 +alt_id: GO:0102316 +def: "Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones." [EC:1.10.3.1, PMID:22120533] +comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. +synonym: "catecholase" EXACT [EC:1.10.3.1] +synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] +synonym: "dopamine monooxygenase activity" NARROW [] +synonym: "L-DOPA monooxygenase activity" NARROW [] +synonym: "L-dopa oxidase activity" NARROW [] +synonym: "o-diphenol oxidoreductase" EXACT [] +synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] +synonym: "phenolase activity" BROAD [EC:1.10.3.1] +synonym: "polyphenol oxidase activity" RELATED [EC:1.10.3.1] +synonym: "pyrocatechol oxidase" BROAD [] +synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] +xref: EC:1.10.3.1 +xref: MetaCyc:CATECHOL-OXIDASE-RXN +xref: MetaCyc:RXN-13061 +xref: RHEA:21632 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0004098 +name: cerebroside-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8] +synonym: "arylsulfatase A activity" RELATED [EC:3.1.6.8] +synonym: "cerebroside sulfate sulfatase activity" RELATED [EC:3.1.6.8] +synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" RELATED [EC:3.1.6.8] +synonym: "cerebroside-sulphatase activity" EXACT [] +xref: EC:3.1.6.8 +xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN +xref: Reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside" +xref: RHEA:21300 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004099 +name: chitin deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] +synonym: "chitin amidohydrolase activity" RELATED [EC:3.5.1.41] +xref: EC:3.5.1.41 +xref: MetaCyc:CHITIN-DEACETYLASE-RXN +xref: RHEA:10464 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0004100 +name: chitin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16] +synonym: "chitin synthetase activity" RELATED [EC:2.4.1.16] +synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" RELATED [EC:2.4.1.16] +synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.16] +synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.16] +synonym: "trans-N-acetylglucosaminosylase activity" RELATED [EC:2.4.1.16] +synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" RELATED [EC:2.4.1.16] +xref: EC:2.4.1.16 +xref: MetaCyc:CHITIN-SYNTHASE-RXN +xref: RHEA:16637 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004102 +name: choline O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18821] +synonym: "acetyl-CoA:choline O-acetyltransferase activity" RELATED [EC:2.3.1.6] +synonym: "CHOACTase activity" RELATED [EC:2.3.1.6] +synonym: "choline acetylase activity" RELATED [EC:2.3.1.6] +synonym: "choline acetyltransferase activity" RELATED [EC:2.3.1.6] +xref: EC:2.3.1.6 +xref: KEGG_REACTION:R01023 +xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-264622 "Cho is acetylated to AcCho by CHAT" +xref: RHEA:18821 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004103 +name: choline kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12837] +synonym: "ATP:choline phosphotransferase activity" RELATED [] +synonym: "choline kinase (phosphorylating)" RELATED [] +synonym: "choline phosphokinase activity" RELATED [] +synonym: "choline-ethanolamine kinase activity" RELATED [] +xref: EC:2.7.1.32 +xref: KEGG_REACTION:R01021 +xref: MetaCyc:CHOLINE-KINASE-RXN +xref: Reactome:R-HSA-1483004 "Cho is phosphorylated to PCho by CHK dimer" +xref: RHEA:12837 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004104 +name: cholinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] +subset: goslim_chembl +synonym: "acylcholine acylhydrolase activity" RELATED [EC:3.1.1.8] +synonym: "anticholineesterase activity" RELATED [EC:3.1.1.8] +synonym: "benzoylcholinesterase activity" RELATED [EC:3.1.1.8] +synonym: "BtChoEase activity" RELATED [EC:3.1.1.8] +synonym: "butyrylcholine esterase activity" RELATED [EC:3.1.1.8] +synonym: "butyrylcholinesterase activity" RELATED [EC:3.1.1.8] +synonym: "choline esterase activity" RELATED [EC:3.1.1.8] +synonym: "choline esterase II (unspecific) activity" RELATED [EC:3.1.1.8] +synonym: "non-specific cholinesterase activity" RELATED [EC:3.1.1.8] +synonym: "propionylcholinesterase activity" RELATED [EC:3.1.1.8] +synonym: "pseudocholinesterase activity" RELATED [EC:3.1.1.8] +xref: EC:3.1.1.8 +xref: MetaCyc:CHOLINESTERASE-RXN +xref: RHEA:21964 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004105 +name: choline-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] +synonym: "CDP-choline pyrophosphorylase activity" RELATED [EC:2.7.7.15] +synonym: "CDP-choline synthetase activity" RELATED [EC:2.7.7.15] +synonym: "choline phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "CTP-phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "CTP:phosphorylcholine cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "cytidine diphosphocholine pyrophosphorylase activity" RELATED [EC:2.7.7.15] +synonym: "phosphocholine cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "phosphorylcholine cytidylyltransferase activity" RELATED [EC:2.7.7.15] +synonym: "phosphorylcholine transferase activity" RELATED [EC:2.7.7.15] +synonym: "phosphorylcholine:CTP cytidylyltransferase activity" RELATED [EC:2.7.7.15] +xref: EC:2.7.7.15 +xref: MetaCyc:2.7.7.15-RXN +xref: Reactome:R-HSA-1483081 "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer" +xref: RHEA:18997 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0004106 +name: chorismate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13897] +synonym: "chorismate pyruvatemutase activity" RELATED [EC:5.4.99.5] +synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] +xref: EC:5.4.99.5 +xref: KEGG_REACTION:R01715 +xref: MetaCyc:CHORISMATEMUT-RXN +xref: RHEA:13897 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0004107 +name: chorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21020] +synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" RELATED [EC:4.2.3.5] +synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" RELATED [EC:4.2.3.5] +synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" RELATED [EC:4.2.3.5] +xref: EC:4.2.3.5 +xref: KEGG_REACTION:R01714 +xref: MetaCyc:CHORISMATE-SYNTHASE-RXN +xref: RHEA:21020 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0004108 +name: citrate (Si)-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] +comment: Note that this function was formerly EC:4.1.3.7. +synonym: "(R)-citric synthase activity" RELATED [EC:2.3.3.1] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] +synonym: "citrate condensing enzyme activity" RELATED [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" RELATED [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" RELATED [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] +synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" RELATED [EC:2.3.3.1] +synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] +synonym: "citrate synthetase activity" RELATED [EC:2.3.3.1] +synonym: "citric synthase activity" RELATED [EC:2.3.3.1] +synonym: "citric-condensing enzyme activity" RELATED [EC:2.3.3.1] +synonym: "citrogenase activity" RELATED [EC:2.3.3.1] +synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] +synonym: "oxalacetic transacetase activity" RELATED [EC:2.3.3.1] +synonym: "oxaloacetate transacetase activity" RELATED [EC:2.3.3.1] +xref: EC:2.3.3.1 +xref: MetaCyc:CITSYN-RXN +xref: Reactome:R-HSA-70975 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA" +is_a: GO:0036440 ! citrate synthase activity + +[Term] +id: GO:0004109 +name: coproporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18257] +synonym: "coprogen oxidase activity" EXACT [] +synonym: "coproporphyrinogen-III oxidase activity" EXACT [] +synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" RELATED [EC:1.3.3.3] +synonym: "coproporphyrinogenase activity" EXACT [] +xref: EC:1.3.3.3 +xref: KEGG_REACTION:R03220 +xref: MetaCyc:RXN0-1461 +xref: Reactome:R-HSA-189421 "CPO transforms COPRO3 to PPGEN9" +xref: RHEA:18257 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0004110 +name: corticosteroid side-chain-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17861] +synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" RELATED [EC:5.3.1.21] +synonym: "11-deoxycorticosterone ketol-isomerase activity" RELATED [EC:5.3.1.21] +xref: EC:5.3.1.21 +xref: KEGG_REACTION:R04165 +xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN +xref: RHEA:17861 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004111 +name: creatine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17157] +synonym: "adenosine triphosphate-creatine transphosphorylase activity" RELATED [EC:2.7.3.2] +synonym: "ATP:creatine N-phosphotransferase activity" RELATED [EC:2.7.3.2] +synonym: "ATP:creatine phosphotransferase activity" RELATED [EC:2.7.3.2] +synonym: "BB-CK" RELATED [EC:2.7.3.2] +synonym: "CK" RELATED [EC:2.7.3.2] +synonym: "CK-BB" RELATED [EC:2.7.3.2] +synonym: "CK-MB" RELATED [EC:2.7.3.2] +synonym: "CK-MM" RELATED [EC:2.7.3.2] +synonym: "CKMiMi" RELATED [EC:2.7.3.2] +synonym: "creatine phosphokinase activity" RELATED [EC:2.7.3.2] +synonym: "creatine phosphotransferase activity" RELATED [EC:2.7.3.2] +synonym: "MB-CK" RELATED [EC:2.7.3.2] +synonym: "Mi-CK" RELATED [EC:2.7.3.2] +synonym: "MiMi-CK" RELATED [EC:2.7.3.2] +synonym: "MM-CK" RELATED [EC:2.7.3.2] +synonym: "phosphocreatine kinase activity" RELATED [EC:2.7.3.2] +xref: EC:2.7.3.2 +xref: KEGG_REACTION:R01881 +xref: MetaCyc:CREATINE-KINASE-RXN +xref: Reactome:R-HSA-200318 "creatine + ATP => phosphocreatine + ADP [CKB,CKM]" +xref: Reactome:R-HSA-200326 "creatine + ATP => phosphocreatine + ADP [CK octamer]" +xref: RHEA:17157 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0004112 +name: cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004113 +name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] +synonym: "2',3'-cyclic AMP phosphodiesterase activity" RELATED [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] +synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.4.37] +synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] +synonym: "2':3'-CNMP-3'-ase activity" RELATED [EC:3.1.4.37] +synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" RELATED [EC:3.1.4.37] +synonym: "CNPase activity" RELATED [EC:3.1.4.37] +synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" RELATED [EC:3.1.4.37] +synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] +synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] +synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" RELATED [EC:3.1.4.37] +xref: EC:3.1.4.37 +xref: MetaCyc:3.1.4.37-RXN +xref: RHEA:14489 +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004114 +name: 3',5'-cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] +synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.17] +synonym: "3',5'-cyclonucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "3',5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED [EC:3.1.4.17] +synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.17] +synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "cyclic 3',5'-phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] +synonym: "cyclic nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" RELATED [EC:3.1.4.17] +synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" RELATED [EC:3.1.4.17] +synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.17] +synonym: "PDE" RELATED [EC:3.1.4.17] +xref: EC:3.1.4.17 +xref: MetaCyc:3.1.4.17-RXN +xref: Reactome:R-HSA-162425 "p-S295-PDE3B hydrolyses cAMP to AMP" +xref: RHEA:14653 +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004115 +name: 3',5'-cyclic-AMP phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai, RHEA:25277] +synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] +synonym: "cAMP-specific phosphodiesterase activity" EXACT [] +synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.53 +xref: MetaCyc:RXN0-5038 +xref: Reactome:R-HSA-111962 "PDE4A,C,D hydrolyse cAMP" +xref: Reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases" +xref: Reactome:R-HSA-9629675 "PDE3A hydrolyses cAMP to AMP" +xref: Reactome:R-HSA-9644869 "p-S54-PDE4B hydrolyses cAMP" +xref: Reactome:R-HSA-9705507 "PDE3B hydrolyses cAMP to AMP" +xref: RHEA:25277 +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004117 +name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] +xref: Reactome:R-HSA-111955 "cAMP hydrolysis by Cam-PDE 1" +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004118 +name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004119 +name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004120 +name: photoreceptor cyclic-nucleotide phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [GOC:curators] +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0004121 +name: cystathionine beta-lyase activity +namespace: molecular_function +alt_id: GO:0008799 +def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] +synonym: "beta C-S lyase activity" RELATED [EC:4.4.1.8] +synonym: "beta-cystathionase activity" RELATED [EC:4.4.1.8] +synonym: "cystathionine L-homocysteine-lyase (deaminating)" RELATED [EC:4.4.1.8] +synonym: "cystine lyase activity" RELATED [EC:4.4.1.8] +synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" RELATED [EC:4.4.1.8] +synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.8] +xref: EC:4.4.1.8 +xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN +xref: RHEA:13965 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004122 +name: cystathionine beta-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] +synonym: "beta-thionase activity" RELATED [EC:4.2.1.22] +synonym: "L-serine hydro-lyase (adding homocysteine)" RELATED [EC:4.2.1.22] +synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" RELATED [EC:4.2.1.22] +synonym: "methylcysteine synthase activity" RELATED [EC:4.2.1.22] +synonym: "serine sulfhydrase activity" RELATED [EC:4.2.1.22] +synonym: "serine sulfhydrylase activity" RELATED [EC:4.2.1.22] +xref: EC:4.2.1.22 +xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN +xref: Reactome:R-HSA-1614524 "PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine" +xref: RHEA:10112 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004123 +name: cystathionine gamma-lyase activity +namespace: molecular_function +alt_id: GO:0016225 +def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:14005] +synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1] +synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1] +synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1] +synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1] +synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1] +synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.1] +xref: EC:4.4.1.1 +xref: KEGG_REACTION:R01001 +xref: MetaCyc:CYSTAGLY-RXN +xref: Reactome:R-HSA-1614583 "PXLP-K212-CTH cleaves L-Cystathionine" +xref: RHEA:14005 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004124 +name: cysteine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:2.5.1.47] +comment: Note that this function was formerly 4.2.99.8. +synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.47] +synonym: "acetylserine sulfhydrylase activity" RELATED [EC:2.5.1.47] +synonym: "cysteine synthetase activity" RELATED [EC:2.5.1.47] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" RELATED [EC:2.5.1.47] +synonym: "O-acetyl-L-serine sulfhydrylase activity" RELATED [EC:2.5.1.47] +synonym: "O-acetyl-L-serine sulfohydrolase activity" RELATED [EC:2.5.1.47] +synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] +synonym: "O-acetylserine (thiol)-lyase activity" RELATED [EC:2.5.1.47] +synonym: "O-acetylserine sulfhydrylase activity" RELATED [EC:2.5.1.47] +synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" RELATED [EC:2.5.1.47] +synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.47] +synonym: "OAS sulfhydrylase activity" RELATED [EC:2.5.1.47] +xref: EC:2.5.1.47 +xref: MetaCyc:ACSERLY-RXN +xref: RHEA:14829 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004125 +name: L-seryl-tRNASec selenium transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [RHEA:22728] +synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" RELATED [EC:2.9.1.1] +synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" RELATED [EC:2.9.1.1] +synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] +synonym: "cysteinyl-tRNASec-selenium transferase activity" RELATED [EC:2.9.1.1] +synonym: "cysteinyl-tRNASel-selenium transferase activity" RELATED [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" RELATED [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" RELATED [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNASec synthase activity" RELATED [EC:2.9.1.1] +synonym: "L-selenocysteinyl-tRNASel synthase activity" RELATED [EC:2.9.1.1] +synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] +synonym: "selenocysteine synthase activity" EXACT [] +synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] +synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" RELATED [EC:2.9.1.1] +xref: EC:2.9.1.1 +xref: MetaCyc:2.9.1.1-RXN +xref: RHEA:22728 +is_a: GO:0016785 ! selenotransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0004126 +name: cytidine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] +synonym: "cytidine aminohydrolase activity" RELATED [EC:3.5.4.5] +synonym: "cytosine nucleoside deaminase activity" RELATED [EC:3.5.4.5] +xref: EC:3.5.4.5 +xref: MetaCyc:CYTIDEAM2-RXN +xref: Reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)" +xref: Reactome:R-HSA-83677 "C4 deamination of cytidine" +xref: RHEA:16069 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004127 +name: cytidylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] +synonym: "ATP:CMP phosphotransferase activity" RELATED [EC:2.7.4.14] +synonym: "ATP:UMP-CMP phosphotransferase activity" RELATED [EC:2.7.4.14] +synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] +synonym: "CTP:CMP phosphotransferase activity" RELATED [EC:2.7.4.14] +synonym: "cytidine monophosphate kinase activity" RELATED [EC:2.7.4.14] +synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] +synonym: "deoxycytidine monophosphokinase activity" RELATED [EC:2.7.4.14] +synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] +synonym: "pyrimidine nucleoside monophosphate kinase activity" RELATED [EC:2.7.4.14] +synonym: "UMP-CMP kinase activity" RELATED [EC:2.7.4.14] +xref: EC:2.7.4.14 +xref: MetaCyc:CMPKI-RXN +is_a: GO:0050145 ! nucleoside monophosphate kinase activity + +[Term] +id: GO:0004128 +name: cytochrome-b5 reductase activity, acting on NAD(P)H +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] +synonym: "cytochrome b5 reductase activity" RELATED [EC:1.6.2.2] +synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2] +synonym: "NADH 5alpha-reductase activity" RELATED [EC:1.6.2.2] +synonym: "NADH-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2] +synonym: "NADH-cytochrome-b5 reductase activity" RELATED [EC:1.6.2.2] +synonym: "NADH-ferricytochrome b5 oxidoreductase activity" RELATED [EC:1.6.2.2] +synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" RELATED [EC:1.6.2.2] +synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" RELATED [EC:1.6.2.2] +xref: EC:1.6.2.2 +xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN +xref: Reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme" +xref: Reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA" +xref: RHEA:46680 +is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor + +[Term] +id: GO:0004129 +name: cytochrome-c oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [RHEA:11436] +comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. +synonym: "aa3-type cytochrome c oxidase" NARROW [EC:7.1.1.9] +synonym: "ba3-type cytochrome c oxidase" NARROW [EC:7.1.1.9] +synonym: "caa3-type cytochrome c oxidase" NARROW [EC:7.1.1.9] +synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:7.1.1.9] +synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:7.1.1.9] +synonym: "cytochrome a3 activity" NARROW [EC:7.1.1.9] +synonym: "cytochrome aa3 activity" NARROW [EC:7.1.1.9] +synonym: "cytochrome c oxidase activity" EXACT [] +synonym: "cytochrome oxidase activity" RELATED [EC:7.1.1.9] +synonym: "indophenol oxidase" NARROW [] +synonym: "indophenolase" NARROW [] +synonym: "Warburg's respiratory enzyme activity" RELATED [EC:7.1.1.9] +xref: EC:7.1.1.9 +xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN +xref: Reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen" +xref: RHEA:11436 +is_a: GO:0009055 ! electron transfer activity +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0004130 +name: cytochrome-c peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] +synonym: "apocytochrome c peroxidase activity" RELATED [EC:1.11.1.5] +synonym: "cytochrome c peroxidase activity" RELATED [EC:1.11.1.5] +synonym: "cytochrome c-551 peroxidase activity" RELATED [EC:1.11.1.5] +synonym: "cytochrome c-H2O oxidoreductase activity" RELATED [EC:1.11.1.5] +synonym: "cytochrome peroxidase activity" RELATED [EC:1.11.1.5] +synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] +synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] +xref: EC:1.11.1.5 +xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN +xref: RHEA:16581 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004131 +name: cytosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] +synonym: "cytosine aminohydrolase activity" RELATED [EC:3.5.4.1] +synonym: "isocytosine deaminase activity" RELATED [EC:3.5.4.1] +xref: EC:3.5.4.1 +xref: MetaCyc:CYTDEAM-RXN +xref: RHEA:20605 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004132 +name: dCMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] +synonym: "dCMP aminohydrolase activity" RELATED [EC:3.5.4.12] +synonym: "deoxy-CMP-deaminase activity" RELATED [EC:3.5.4.12] +synonym: "deoxycytidine monophosphate deaminase activity" RELATED [EC:3.5.4.12] +synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" RELATED [EC:3.5.4.12] +synonym: "deoxycytidine-5'-phosphate deaminase activity" RELATED [EC:3.5.4.12] +synonym: "deoxycytidylate aminohydrolase activity" RELATED [EC:3.5.4.12] +synonym: "deoxycytidylate deaminase activity" RELATED [EC:3.5.4.12] +xref: EC:3.5.4.12 +xref: MetaCyc:DCMP-DEAMINASE-RXN +xref: Reactome:R-HSA-73596 "dCMP + H2O => dUMP + NH4+" +xref: RHEA:22924 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004133 +name: glycogen debranching enzyme activity +namespace: molecular_function +def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732] +subset: goslim_pir +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0004134 +name: 4-alpha-glucanotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" RELATED [EC:2.4.1.25] +synonym: "amylomaltase activity" RELATED [EC:2.4.1.25] +synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] +synonym: "debranching enzyme maltodextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] +synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] +synonym: "dextrin transglycosylase activity" RELATED [EC:2.4.1.25] +synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] +synonym: "oligo-1,4-1,4-glucantransferase activity" RELATED [EC:2.4.1.25] +xref: EC:2.4.1.25 +xref: MetaCyc:AMYLOMALT-RXN +xref: MetaCyc:RXN-1828 +xref: MetaCyc:RXN-9023 +xref: Reactome:R-HSA-71552 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin" +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0004135 +name: amylo-alpha-1,6-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732] +synonym: "amylo-1,6-glucosidase activity" EXACT [] +synonym: "amylopectin 1,6-glucosidase activity" RELATED [EC:3.2.1.33] +synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] +synonym: "dextrin-1,6-glucosidase activity" RELATED [EC:3.2.1.33] +synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" RELATED [EC:3.2.1.33] +xref: EC:3.2.1.33 +xref: MetaCyc:3.2.1.33-RXN +xref: Reactome:R-HSA-71593 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose" +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0004136 +name: deoxyadenosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23452] +synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.76] +synonym: "deoxyadenosine kinase (phosphorylating)" RELATED [EC:2.7.1.76] +synonym: "purine-deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.76] +xref: EC:2.7.1.76 +xref: KEGG_REACTION:R02089 +xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN +xref: RHEA:23452 +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004137 +name: deoxycytidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] +synonym: "2'-deoxycytidine kinase activity" RELATED [EC:2.7.1.74] +synonym: "Ara-C kinase activity" RELATED [EC:2.7.1.74] +synonym: "arabinofuranosylcytosine kinase activity" RELATED [EC:2.7.1.74] +synonym: "deoxycytidine kinase (phosphorylating)" RELATED [EC:2.7.1.74] +synonym: "deoxycytidine-cytidine kinase activity" RELATED [EC:2.7.1.74] +synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.74] +xref: EC:2.7.1.74 +xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN +xref: RHEA:20061 +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004138 +name: deoxyguanosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19201] +synonym: "(dihydroxypropoxymethyl)guanine kinase activity" RELATED [EC:2.7.1.113] +synonym: "2'-deoxyguanosine kinase activity" RELATED [EC:2.7.1.113] +synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.113] +synonym: "deoxyguanosine kinase (phosphorylating)" RELATED [EC:2.7.1.113] +synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.113] +xref: EC:2.7.1.113 +xref: KEGG_REACTION:R01967 +xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN +xref: RHEA:19201 +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004139 +name: deoxyribose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12821] +synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" RELATED [EC:4.1.2.4] +synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" RELATED [EC:4.1.2.4] +synonym: "2-deoxyribose-5-phosphate aldolase activity" RELATED [EC:4.1.2.4] +synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] +synonym: "deoxyribose-5-phosphate aldolase activity" RELATED [EC:4.1.2.4] +synonym: "phosphodeoxyriboaldolase activity" RELATED [EC:4.1.2.4] +xref: EC:4.1.2.4 +xref: KEGG_REACTION:R01066 +xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN +xref: Reactome:R-HSA-6787321 "DERA cleaves dR5P to GA3P and CH3CHO" +xref: RHEA:12821 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004140 +name: dephospho-CoA kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18245] +synonym: "3'-dephospho-CoA kinase activity" RELATED [EC:2.7.1.24] +synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" RELATED [EC:2.7.1.24] +synonym: "dephosphocoenzyme A kinase (phosphorylating)" RELATED [EC:2.7.1.24] +synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] +xref: EC:2.7.1.24 +xref: KEGG_REACTION:R00130 +xref: MetaCyc:DEPHOSPHOCOAKIN-RXN +xref: Reactome:R-HSA-196773 "COASY phosphorylates DP-CoA" +xref: RHEA:18245 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004141 +name: dethiobiotin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15805] +synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.3] +synonym: "desthiobiotin synthase activity" RELATED [EC:6.3.3.3] +synonym: "DTB synthetase activity" RELATED [EC:6.3.3.3] +xref: EC:6.3.3.3 +xref: KEGG_REACTION:R03182 +xref: MetaCyc:DETHIOBIOTIN-SYN-RXN +xref: RHEA:15805 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0004142 +name: diacylglycerol cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2, RHEA:32939] +synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "alkylacylglycerol choline phosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "alkylacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "CDP-choline diglyceride phosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "CPT" RELATED [EC:2.7.8.2] +synonym: "cytidine diphosphocholine glyceride transferase activity" RELATED [EC:2.7.8.2] +synonym: "cytidine diphosphorylcholine diglyceride transferase activity" RELATED [EC:2.7.8.2] +synonym: "diacylglycerol choline phosphotransferase activity" RELATED [EC:2.7.8.2] +synonym: "phosphocholine diacylglyceroltransferase activity" RELATED [EC:2.7.8.2] +synonym: "phosphorylcholine--glyceride transferase activity" RELATED [EC:2.7.8.2] +synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.2] +xref: EC:2.7.8.2 +xref: MetaCyc:RXN-5781 +xref: Reactome:R-HSA-1482961 "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane" +xref: Reactome:R-HSA-1482973 "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane" +xref: RHEA:32939 +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0004143 +name: diacylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] +synonym: "1,2-diacylglycerol kinase (phosphorylating)" RELATED [EC:2.7.1.107] +synonym: "1,2-diacylglycerol kinase activity" RELATED [EC:2.7.1.107] +synonym: "arachidonoyl-specific diacylglycerol kinase activity" RELATED [EC:2.7.1.107] +synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] +synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] +synonym: "CTP:diacylglycerol kinase activity" NARROW [] +synonym: "DG kinase activity" RELATED [EC:2.7.1.107] +synonym: "DGK activity" RELATED [EC:2.7.1.107] +synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] +synonym: "diglyceride kinase activity" RELATED [EC:2.7.1.107] +synonym: "sn-1,2-diacylglycerol kinase activity" RELATED [EC:2.7.1.107] +xref: EC:2.7.1.107 +xref: MetaCyc:DIACYLGLYKIN-RXN +xref: Reactome:R-HSA-426240 "DAG kinase produces phosphatidic acid from DAG" +xref: RHEA:10272 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004144 +name: diacylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] +synonym: "1,2-diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20] +synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.20] +synonym: "diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20] +synonym: "diglyceride acyltransferase activity" RELATED [EC:2.3.1.20] +synonym: "diglyceride O-acyltransferase activity" RELATED [EC:2.3.1.20] +synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" RELATED [EC:2.3.1.20] +xref: EC:2.3.1.20 +xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-1482889 "DAG is acylated to TAG by DGAT1/2" +xref: Reactome:R-HSA-549192 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]" +xref: Reactome:R-HSA-75900 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]" +xref: Reactome:R-HSA-8848580 "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG" +xref: RHEA:10868 +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0004145 +name: diamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] +synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" RELATED [EC:2.3.1.57] +synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] +synonym: "diamine acetyltransferase activity" EXACT [] +synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] +synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] +synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] +synonym: "spermidine N1-acetyltransferase activity" RELATED [EC:2.3.1.57] +synonym: "spermidine/spermine N1-acetyltransferase activity" RELATED [EC:2.3.1.57] +synonym: "spermine acetyltransferase" NARROW [] +synonym: "spermine N(1)-acetyltransferase" NARROW [] +synonym: "spermine N-acetyltransferase" RELATED [] +xref: EC:2.3.1.57 +xref: MetaCyc:DIAMACTRANS-RXN +xref: Reactome:R-HSA-351207 "Spermine => N-acetylated spermine" +xref: Reactome:R-HSA-351208 "Spermidine => N-acetylated spermidine" +xref: RHEA:25181 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004146 +name: dihydrofolate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] +synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.3] +synonym: "7,8-dihydrofolate reductase activity" RELATED [EC:1.5.1.3] +synonym: "DHFR" RELATED [EC:1.5.1.3] +synonym: "dihydrofolate reductase:thymidylate synthase activity" RELATED [EC:1.5.1.3] +synonym: "dihydrofolate reduction" EXACT [] +synonym: "dihydrofolic acid reductase activity" RELATED [EC:1.5.1.3] +synonym: "dihydrofolic reductase activity" RELATED [EC:1.5.1.3] +synonym: "folic acid reductase activity" RELATED [EC:1.5.1.3] +synonym: "folic reductase activity" RELATED [EC:1.5.1.3] +synonym: "NADPH-dihydrofolate reductase activity" RELATED [EC:1.5.1.3] +synonym: "pteridine reductase:dihydrofolate reductase activity" RELATED [EC:1.5.1.3] +synonym: "tetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.3] +synonym: "thymidylate synthetase-dihydrofolate reductase activity" RELATED [EC:1.5.1.3] +xref: EC:1.5.1.3 +xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN +xref: Reactome:R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR" +xref: RHEA:15009 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004147 +name: dihydrolipoamide branched chain acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] +synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] +is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity + +[Term] +id: GO:0004148 +name: dihydrolipoyl dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] +synonym: "dehydrolipoate dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "diaphorase activity" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoamide dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoamide:NAD+ oxidoreductase" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoic dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] +synonym: "dihydrothioctic dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] +synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] +synonym: "L-protein activity" RELATED [EC:1.8.1.4] +synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] +synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] +synonym: "lipoamide dehydrogenase (NADH) activity" RELATED [EC:1.8.1.4] +synonym: "lipoamide oxidoreductase (NADH) activity" RELATED [EC:1.8.1.4] +synonym: "lipoamide reductase (NADH) activity" RELATED [EC:1.8.1.4] +synonym: "lipoamide reductase activity" RELATED [EC:1.8.1.4] +synonym: "lipoate dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "lipoic acid dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "lipoyl dehydrogenase activity" RELATED [EC:1.8.1.4] +synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED [EC:1.8.1.4] +synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" RELATED [EC:1.8.1.4] +xref: EC:1.8.1.4 +xref: MetaCyc:DIHYDLIPOXN-RXN +xref: Reactome:R-HSA-1222412 "lpdC dimer reactivates dlaT" +xref: Reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate" +xref: RHEA:15045 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0004149 +name: dihydrolipoyllysine-residue succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] +synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] +synonym: "dihydrolipoamide succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "dihydrolipoic transsuccinylase activity" RELATED [EC:2.3.1.61] +synonym: "dihydrolipolyl transsuccinylase activity" RELATED [EC:2.3.1.61] +synonym: "dihydrolipoyl transsuccinylase activity" RELATED [EC:2.3.1.61] +synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "lipoate succinyltransferase (Escherichia coli) activity" RELATED [EC:2.3.1.61] +synonym: "lipoate succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "lipoic transsuccinylase activity" RELATED [EC:2.3.1.61] +synonym: "lipoyl transsuccinylase activity" RELATED [EC:2.3.1.61] +synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" RELATED [EC:2.3.1.61] +synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" RELATED [EC:2.3.1.61] +xref: EC:2.3.1.61 +xref: RHEA:15213 +is_a: GO:0016751 ! S-succinyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004150 +name: dihydroneopterin aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] +synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" RELATED [EC:4.1.2.25] +synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" RELATED [EC:4.1.2.25] +xref: EC:4.1.2.25 +xref: MetaCyc:H2NEOPTERINALDOL-RXN +xref: RHEA:10540 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004151 +name: dihydroorotase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24296] +synonym: "(S)-dihydroorotate amidohydrolase activity" RELATED [EC:3.5.2.3] +synonym: "carbamoylaspartic dehydrase activity" RELATED [EC:3.5.2.3] +synonym: "DHOase activity" RELATED [EC:3.5.2.3] +synonym: "dihydroorotate hydrolase activity" RELATED [EC:3.5.2.3] +xref: EC:3.5.2.3 +xref: KEGG_REACTION:R01993 +xref: MetaCyc:DIHYDROOROT-RXN +xref: Reactome:R-HSA-73571 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O" +xref: RHEA:24296 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004152 +name: dihydroorotate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18073] +synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2] +synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2] +synonym: "DHOdehase activity" RELATED [EC:1.3.5.2] +synonym: "dihydoorotic acid dehydrogenase activity" RELATED [EC:1.3.5.2] +synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2] +xref: EC:1.3.5.2 +xref: KEGG_REACTION:R01868 +xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-73569 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol" +xref: RHEA:18073 +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0004153 +name: dihydropterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [GOC:jl, PMID:19567870] +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004154 +name: dihydropterin oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189] +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0004155 +name: 6,7-dihydropteridine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] +comment: Note that this function was formerly EC:1.6.99.7. +synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" RELATED [EC:1.5.1.34] +synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" RELATED [EC:1.5.1.34] +synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" RELATED [EC:1.5.1.34] +synonym: "DHPR activity" RELATED [EC:1.5.1.34] +synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.34] +synonym: "dihydropteridine reductase (NADH) activity" RELATED [EC:1.5.1.34] +synonym: "dihydropteridine reductase activity" EXACT [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" RELATED [EC:1.5.1.34] +synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" RELATED [EC:1.5.1.34] +synonym: "NADH-dihydropteridine reductase activity" RELATED [EC:1.5.1.34] +synonym: "NADPH-dihydropteridine reductase activity" RELATED [EC:1.5.1.34] +synonym: "NADPH-specific dihydropteridine reductase activity" RELATED [EC:1.5.1.34] +xref: EC:1.5.1.34 +xref: MetaCyc:1.5.1.34-RXN +xref: Reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+" +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004156 +name: dihydropteroate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] +synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" RELATED [EC:2.5.1.15] +synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" RELATED [EC:2.5.1.15] +synonym: "7,8-dihydropteroate synthase activity" RELATED [EC:2.5.1.15] +synonym: "7,8-dihydropteroate synthetase activity" RELATED [EC:2.5.1.15] +synonym: "7,8-dihydropteroic acid synthetase activity" RELATED [EC:2.5.1.15] +synonym: "DHPS activity" RELATED [EC:2.5.1.15] +synonym: "dihydropteroate diphosphorylase activity" RELATED [EC:2.5.1.15] +synonym: "dihydropteroate pyrophosphorylase activity" RELATED [EC:2.5.1.15] +synonym: "dihydropteroate synthetase activity" RELATED [EC:2.5.1.15] +synonym: "dihydropteroic synthetase activity" RELATED [EC:2.5.1.15] +xref: EC:2.5.1.15 +xref: MetaCyc:H2PTEROATESYNTH-RXN +xref: RHEA:19949 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004157 +name: dihydropyrimidinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] +synonym: "5,6-dihydropyrimidine amidohydrolase activity" RELATED [EC:3.5.2.2] +synonym: "D-hydantoinase activity" RELATED [EC:3.5.2.2] +synonym: "hydantoin peptidase activity" RELATED [EC:3.5.2.2] +synonym: "hydantoinase activity" RELATED [EC:3.5.2.2] +synonym: "hydropyrimidine hydrase activity" RELATED [EC:3.5.2.2] +synonym: "pyrimidine hydrase activity" RELATED [EC:3.5.2.2] +xref: EC:3.5.2.2 +xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN +xref: Reactome:R-HSA-73589 "5,6-dihydrouracil + H2O => beta-ureidopropionate" +xref: Reactome:R-HSA-73618 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate" +xref: RHEA:16121 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0004158 +name: dihydroorotate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [RHEA:15441] +synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" RELATED [] +synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" RELATED [] +xref: RHEA:15441 +is_a: GO:0004152 ! dihydroorotate dehydrogenase activity +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0004159 +name: dihydropyrimidine dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+." [PMID:23150645] +synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" RELATED [] +synonym: "dihydrothymine dehydrogenase (NAD+) activity" NARROW [] +synonym: "dihydrouracil dehydrogenase (NAD+) activity" NARROW [] +synonym: "pyrimidine reductase activity" RELATED [] +synonym: "thymine reductase activity" NARROW [] +synonym: "uracil reductase activity" NARROW [] +xref: EC:1.3.1.1 +xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004160 +name: dihydroxy-acid dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] +synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" RELATED [EC:4.2.1.9] +synonym: "2,3-dihydroxy-acid hydro-lyase activity" RELATED [EC:4.2.1.9] +synonym: "2,3-dihydroxyisovalerate dehydratase activity" RELATED [EC:4.2.1.9] +synonym: "acetohydroxyacid dehydratase activity" RELATED [EC:4.2.1.9] +synonym: "alpha,beta-dihydroxyacid dehydratase activity" RELATED [EC:4.2.1.9] +synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" RELATED [EC:4.2.1.9] +synonym: "DHAD" RELATED [EC:4.2.1.9] +synonym: "dihydroxy acid dehydrase activity" RELATED [EC:4.2.1.9] +xref: EC:4.2.1.9 +xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN +xref: RHEA:20936 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004161 +name: dimethylallyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] +comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. +synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.1] +synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" RELATED [EC:2.5.1.1] +synonym: "dimethylallyltransferase activity" EXACT [] +synonym: "diprenyltransferase activity" RELATED [EC:2.5.1.1] +synonym: "DMAPP:IPP-dimethylallyltransferase activity" RELATED [EC:2.5.1.1] +synonym: "geranyl diphosphate synthase" EXACT [] +synonym: "geranyl pyrophosphate synthase activity" RELATED [EC:2.5.1.1] +synonym: "geranyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1] +synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] +synonym: "trans-farnesyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.1] +xref: EC:2.5.1.1 +xref: MetaCyc:GPPSYN-RXN +xref: Reactome:R-HSA-191322 "Addition of isopentenyl pyrophosphate to DMAPP" +xref: RHEA:22408 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004162 +name: dimethylnitrosamine demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] +synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0004163 +name: diphosphomevalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23732] +synonym: "5-pyrophosphomevalonate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" RELATED [EC:4.1.1.33] +synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" RELATED [EC:4.1.1.33] +synonym: "mevalonate 5-diphosphate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "mevalonate diphosphate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "mevalonate pyrophosphate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "mevalonate-5-pyrophosphate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "pyrophosphomevalonate decarboxylase activity" RELATED [EC:4.1.1.33] +synonym: "pyrophosphomevalonic acid decarboxylase activity" RELATED [EC:4.1.1.33] +xref: EC:4.1.1.33 +xref: KEGG_REACTION:R01121 +xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-191414 "MVD decarboxylates MVA5PP to IPPP" +xref: RHEA:23732 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004164 +name: diphthine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [PMID:15485916, PMID:20873788, PMID:3042777] +synonym: "diphthine methyltransferase activity" RELATED [EC:2.1.1.98] +synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" RELATED [EC:2.1.1.98] +synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" RELATED [EC:2.1.1.98] +xref: EC:2.1.1.98 +xref: MetaCyc:RXN-11370 +xref: Reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2" +xref: RHEA:36415 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004165 +name: delta(3)-delta(2)-enoyl-CoA isomerase activity +namespace: molecular_function +alt_id: GO:0008461 +def: "Catalysis of the reactions: a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA or a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA." [RHEA:45228, RHEA:45900] +synonym: "3,2-trans-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8] +synonym: "acetylene-allene isomerase activity" RELATED [EC:5.3.3.8] +synonym: "delta(3),delta(2)-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8] +synonym: "delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8] +synonym: "delta3,delta2-enoyl-CoA isomerase activity" RELATED [EC:5.3.3.8] +synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" EXACT [EC:5.3.3.8] +synonym: "delta3-delta2 enoyl-CoA isomerase activity" EXACT [] +synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" NARROW [EC:5.3.3.8] +synonym: "dodecenoyl-CoA D-isomerase activity" NARROW [] +synonym: "dodecenoyl-CoA delta-isomerase activity" NARROW [] +synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" NARROW [EC:5.3.3.8] +synonym: "dodecenoyl-CoA isomerase activity" RELATED [EC:5.3.3.8] +xref: EC:5.3.3.8 +xref: MetaCyc:RXN-7931 {xref="skos:narrowMatch"} +xref: Reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA" +xref: Reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA" +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004166 +name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +alt_id: GO:0004101 +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] +synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.153] +xref: EC:2.4.1.153 +xref: MetaCyc:2.4.1.153-RXN +xref: RHEA:14693 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004167 +name: dopachrome isomerase activity +namespace: molecular_function +alt_id: GO:0048059 +def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13041] +synonym: "DCF activity" RELATED [EC:5.3.3.12] +synonym: "DCT activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome conversion activity" BROAD [] +synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] +synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome delta-isomerase activity" EXACT [] +synonym: "dopachrome delta7,Delta2-isomerase activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome keto-enol isomerase activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome oxidoreductase activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome rearranging enzyme activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome tautomerase activity" RELATED [EC:5.3.3.12] +synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] +synonym: "L-dopachrome isomerase activity" RELATED [EC:5.3.3.12] +synonym: "L-dopachrome keto-enol isomerase activity" RELATED [EC:5.3.3.12] +synonym: "L-dopachrome-methyl ester tautomerase activity" RELATED [EC:5.3.3.12] +synonym: "TRP activity" RELATED [EC:5.3.3.12] +synonym: "TRP-1" RELATED [EC:5.3.3.12] +synonym: "TRP-2" RELATED [EC:5.3.3.12] +synonym: "TRP2" RELATED [EC:5.3.3.12] +synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] +synonym: "tyrosinase-related protein 2 activity" RELATED [EC:5.3.3.12] +xref: EC:5.3.3.12 +xref: KEGG_REACTION:R03673 +xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN +xref: RHEA:13041 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004168 +name: dolichol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] +synonym: "CTP:dolichol O-phosphotransferase activity" RELATED [EC:2.7.1.108] +synonym: "dolichol phosphokinase activity" RELATED [EC:2.7.1.108] +xref: EC:2.7.1.108 +xref: MetaCyc:DOLICHOL-KINASE-RXN +xref: Reactome:R-HSA-446195 "DOLK phosphorylates DCHOL to DOLP" +xref: Reactome:R-HSA-4755600 "Defective DOLK does not phosphorylate DCHOL" +xref: RHEA:13133 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004169 +name: dolichyl-phosphate-mannose-protein mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr] +comment: Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. +synonym: "dolichol phosphomannose-protein mannosyltransferase activity" RELATED [EC:2.4.1.109] +synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" RELATED [EC:2.4.1.109] +synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] +synonym: "O-glycoside mannosyltransferase" BROAD [] +synonym: "protein O-D-mannosyltransferase activity" RELATED [EC:2.4.1.109] +synonym: "protein O-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.109 +xref: MetaCyc:2.4.1.109-RXN +xref: Reactome:R-HSA-5615556 "Defective POMT2 does not transfer Man from Dol-P-Man to DAG1" +xref: Reactome:R-HSA-5615604 "Defective POMT1 does not transfer Man from Dol-P-Man to DAG1" +xref: Reactome:R-HSA-5615637 "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)" +is_a: GO:0000030 ! mannosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004170 +name: dUTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [RHEA:10248] +subset: goslim_chembl +synonym: "deoxyuridine-triphosphatase activity" RELATED [EC:3.6.1.23] +synonym: "desoxyuridine 5'-triphosphatase activity" RELATED [EC:3.6.1.23] +synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.23] +synonym: "dUTP nucleotidohydrolase activity" RELATED [EC:3.6.1.23] +synonym: "dUTP pyrophosphatase activity" EXACT [] +synonym: "dUTPase activity" RELATED [EC:3.6.1.23] +xref: EC:3.6.1.23 +xref: KEGG_REACTION:R02100 +xref: MetaCyc:DUTP-PYROP-RXN +xref: Reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate" +xref: RHEA:10248 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0004171 +name: obsolete deoxyhypusine synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] +comment: This term was made obsolete because it represents a multistep reaction. +synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] +synonym: "deoxyhypusine synthase activity" EXACT [] +is_obsolete: true +consider: GO:0008612 +consider: GO:0034038 + +[Term] +id: GO:0004172 +name: obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" EXACT [] +is_obsolete: true +consider: GO:0050488 + +[Term] +id: GO:0004173 +name: ecdysone O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15217] +synonym: "acyl-CoA:ecdysone acyltransferase activity" RELATED [EC:2.3.1.139] +synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" RELATED [EC:2.3.1.139] +synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" RELATED [EC:2.3.1.139] +xref: EC:2.3.1.139 +xref: KEGG_REACTION:R02375 +xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN +xref: RHEA:15217 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004174 +name: electron-transferring-flavoprotein dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]." [RHEA:24052] +synonym: "electron transfer flavoprotein dehydrogenase activity" RELATED [EC:1.5.5.1] +synonym: "electron transfer flavoprotein Q oxidoreductase activity" RELATED [EC:1.5.5.1] +synonym: "electron transfer flavoprotein reductase activity" RELATED [EC:1.5.5.1] +synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1] +synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1] +synonym: "ETF dehydrogenase activity" RELATED [EC:1.5.5.1] +synonym: "ETF-QO activity" RELATED [EC:1.5.5.1] +synonym: "ETF-ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1] +synonym: "ETF:ubiquinone oxidoreductase activity" RELATED [EC:1.5.5.1] +xref: EC:1.5.5.1 +xref: MetaCyc:1.5.5.1-RXN +xref: Reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2" +xref: RHEA:24052 +is_a: GO:0009055 ! electron transfer activity +is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0004175 +name: endopeptidase activity +namespace: molecular_function +alt_id: GO:0016809 +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] +synonym: "elastase activity" RELATED [GOC:krc] +synonym: "endoprotease activity" NARROW [] +synonym: "proteasome endopeptidase activity" NARROW [] +synonym: "proteinase" NARROW [] +xref: MetaCyc:RXN0-5195 +xref: Reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded" +xref: Reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha" +xref: Reactome:R-HSA-1236935 "Proteasomal cleavage of substrate" +xref: Reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen" +xref: Reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex" +xref: Reactome:R-HSA-1433374 "Processing of SCF isoform 1" +xref: Reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome" +xref: Reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1" +xref: Reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins" +xref: Reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin" +xref: Reactome:R-HSA-174203 "SCF-mediated degradation of Emi1" +xref: Reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A" +xref: Reactome:R-HSA-180573 "Degradation of ubiquitinated CD4" +xref: Reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G" +xref: Reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome" +xref: Reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2" +xref: Reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain" +xref: Reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex" +xref: Reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34" +xref: Reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome" +xref: Reactome:R-HSA-2213200 "Release of endostatin-like peptides" +xref: Reactome:R-HSA-264458 "Proteasome mediated degradation of COP1" +xref: Reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex" +xref: Reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome" +xref: Reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2" +xref: Reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed" +xref: Reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome" +xref: Reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome" +xref: Reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome" +xref: Reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors" +xref: Reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage" +xref: Reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome" +xref: Reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome" +xref: Reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex" +xref: Reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB" +xref: Reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor" +xref: Reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome" +xref: Reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP" +xref: Reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH" +xref: Reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome" +xref: Reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome" +xref: Reactome:R-HSA-5658430 "NF1 is degraded by the proteasome" +xref: Reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3" +xref: Reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK" +xref: Reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome" +xref: Reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)" +xref: Reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" +xref: Reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" +xref: Reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome" +xref: Reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome" +xref: Reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome" +xref: Reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A" +xref: Reactome:R-HSA-74730 "Insulin degradation" +xref: Reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1" +xref: Reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin" +xref: Reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN" +xref: Reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53" +xref: Reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7" +xref: Reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7" +xref: Reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome" +xref: Reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome" +xref: Reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin" +xref: Reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2" +xref: Reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome" +xref: Reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH" +xref: Reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2" +xref: Reactome:R-HSA-9008475 "Proteasome degrades polyubiquitinated RUNX2" +xref: Reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2" +xref: Reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)" +xref: Reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1" +xref: Reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4" +xref: Reactome:R-HSA-9614271 "Autocleavage of ADGRG6" +xref: Reactome:R-HSA-983150 "Proteasomal cleavage of substrate" +xref: Reactome:R-HSA-983158 "Trimming of peptides in ER" +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0004176 +name: ATP-dependent peptidase activity +namespace: molecular_function +alt_id: GO:0004280 +def: "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis." [GOC:mah] +synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] +xref: Reactome:R-HSA-9698929 "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex" +is_a: GO:0008233 ! peptidase activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0004177 +name: aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] +xref: EC:3.4.11.- +xref: MetaCyc:RXN0-5052 +xref: Reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles" +xref: Reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1" +xref: Reactome:R-HSA-8851929 "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41)" +xref: Reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases" +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0004178 +name: obsolete leucyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] +synonym: "cathepsin III" RELATED [EC:3.4.11.1] +synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] +synonym: "FTBL proteins" RELATED [EC:3.4.11.1] +synonym: "L-leucine aminopeptidase activity" RELATED [EC:3.4.11.1] +synonym: "leucinamide aminopeptidase activity" RELATED [EC:3.4.11.1] +synonym: "leucinaminopeptidase activity" RELATED [EC:3.4.11.1] +synonym: "leucine aminopeptidase activity" RELATED [EC:3.4.11.1] +synonym: "leucyl aminopeptidase activity" EXACT [] +synonym: "leucyl peptidase activity" RELATED [EC:3.4.11.1] +synonym: "peptidase S activity" NARROW [EC:3.4.11.1] +synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] +xref: EC:3.4.11.1 +xref: MetaCyc:3.4.11.1-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0004179 +name: obsolete membrane alanyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "alanine-specific aminopeptidase activity" RELATED [EC:3.4.11.2] +synonym: "alanyl aminopeptidase activity" RELATED [EC:3.4.11.2] +synonym: "amino-oligopeptidase activity" RELATED [EC:3.4.11.2] +synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] +synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] +synonym: "CD13" RELATED [EC:3.4.11.2] +synonym: "cysteinylglycinase activity" RELATED [EC:3.4.11.2] +synonym: "cysteinylglycine dipeptidase activity" RELATED [EC:3.4.11.2] +synonym: "L-alanine aminopeptidase activity" RELATED [EC:3.4.11.2] +synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "membrane alanyl aminopeptidase activity" EXACT [] +synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] +synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] +synonym: "peptidase E activity" BROAD [EC:3.4.11.2] +synonym: "pseudo leucine aminopeptidase activity" RELATED [EC:3.4.11.2] +xref: EC:3.4.11.2 +xref: MetaCyc:3.4.11.2-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0004180 +name: carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE] +xref: Reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly" +xref: RHEA:28783 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0004181 +name: metallocarboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE] +xref: EC:3.4.17.- +xref: Reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)" +xref: Reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)" +xref: Reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)" +xref: Reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a" +xref: Reactome:R-HSA-8866105 "CCPs deglutamylate tubulin" +xref: Reactome:R-HSA-8955712 "SVBP:VASH1,VASH2 hydrolyzes the terminal L-Tyr residue from alphaY-beta tubulin dimer" +xref: Reactome:R-HSA-9023159 "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))" +xref: Reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)" +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0008235 ! metalloexopeptidase activity + +[Term] +id: GO:0004182 +name: obsolete carboxypeptidase A activity +namespace: molecular_function +alt_id: GO:0008731 +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase A activity" EXACT [] +synonym: "carboxypolypeptidase activity" RELATED [EC:3.4.17.1] +synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] +synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004183 +name: obsolete carboxypeptidase E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase E activity" EXACT [] +synonym: "carboxypeptidase H activity" EXACT [] +synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" RELATED [EC:3.4.17.10] +synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] +synonym: "enkephalin precursor carboxypeptidase activity" RELATED [EC:3.4.17.10] +synonym: "enkephalin-precursor endopeptidase activity" RELATED [EC:3.4.17.10] +synonym: "insulin granule-associated carboxypeptidase activity" RELATED [EC:3.4.17.10] +synonym: "membrane-bound carboxypeptidase activity" RELATED [EC:3.4.17.10] +synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004184 +name: obsolete lysine carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] +synonym: "arginine carboxypeptidase activity" RELATED [EC:3.4.17.3] +synonym: "bradykinase activity" RELATED [EC:3.4.17.3] +synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] +synonym: "carboxypeptidase N activity" EXACT [] +synonym: "CPase N" RELATED [EC:3.4.17.3] +synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] +synonym: "creatinine kinase convertase activity" RELATED [EC:3.4.17.3] +synonym: "hippuryllysine hydrolase activity" RELATED [EC:3.4.17.3] +synonym: "kininase I activity" RELATED [EC:3.4.17.3] +synonym: "kininase Ia" RELATED [EC:3.4.17.3] +synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] +synonym: "lysine carboxypeptidase activity" EXACT [] +synonym: "lysine(arginine) carboxypeptidase activity" RELATED [EC:3.4.17.3] +synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] +synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004185 +name: serine-type carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE] +synonym: "serine carboxypeptidase activity" EXACT [] +xref: EC:3.4.16.- +xref: Reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer" +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0070008 ! serine-type exopeptidase activity + +[Term] +id: GO:0004186 +name: obsolete carboxypeptidase C activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase C activity" EXACT [] +synonym: "carboxypeptidase Y activity" RELATED [EC:3.4.16.5] +synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] +synonym: "deamidase" RELATED [EC:3.4.16.5] +synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] +synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] +synonym: "serine carboxypeptidase I activity" RELATED [EC:3.4.16.5] +synonym: "serine-type carboxypeptidase I activity" RELATED [EC:3.4.16.5] +synonym: "vacuolar carboxypeptidase Y" NARROW [] +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004187 +name: obsolete carboxypeptidase D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase D activity" EXACT [] +synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] +synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] +synonym: "carboxypeptidase S1 activity" RELATED [EC:3.4.16.6] +synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] +synonym: "CPDW-II" RELATED [EC:3.4.16.6] +synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] +synonym: "KEX1 carboxypeptidase activity" RELATED [EC:3.4.16.6] +synonym: "KEX1 proteinase activity" RELATED [EC:3.4.16.6] +synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] +synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004188 +name: obsolete serine-type Pro-X carboxypeptidase activity +namespace: molecular_function +alt_id: GO:0008323 +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoacylproline carboxypeptidase activity" RELATED [EC:3.4.16.2] +synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] +synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] +synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] +synonym: "lysosomal Pro-Xaa carboxypeptidase activity" RELATED [EC:3.4.16.2] +synonym: "PCP" RELATED [EC:3.4.16.2] +synonym: "peptidylprolylamino acid carboxypeptidase activity" RELATED [EC:3.4.16.2] +synonym: "proline carboxypeptidase activity" RELATED [EC:3.4.16.2] +synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] +synonym: "prolyl carboxypeptidase activity" RELATED [EC:3.4.16.2] +synonym: "serine-type Pro-X carboxypeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004185 + +[Term] +id: GO:0004189 +name: obsolete tubulinyl-Tyr carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] +comment: This term was made obsolete because it represents a gene product. +synonym: "brain I carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "carboxypeptidase-tubulin activity" RELATED [EC:3.4.17.17] +synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "TTCPase activity" RELATED [EC:3.4.17.17] +synonym: "tubulin carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "tubulin-tyrosine carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "tubulinyl-Tyr carboxypeptidase activity" EXACT [] +synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] +synonym: "tubulinyltyrosine carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "tyrosinotubulin carboxypeptidase activity" RELATED [EC:3.4.17.17] +synonym: "tyrosyltubulin carboxypeptidase activity" RELATED [EC:3.4.17.17] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004190 +name: aspartic-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] +synonym: "aspartate protease activity" NARROW [GOC:mah, GOC:vw] +synonym: "aspartic endopeptidase activity" EXACT [] +synonym: "aspartic protease activity" NARROW [] +synonym: "aspartyl protease activity" NARROW [] +synonym: "carboxyl protease activity" NARROW [] +xref: EC:3.4.23.- +xref: Reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" +xref: Reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" +xref: Reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" +xref: Reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)" +xref: Reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" +xref: Reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants" +xref: Reactome:R-HSA-373705 "Caspase cleavage of DCC" +xref: Reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3" +xref: Reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3" +xref: Reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4" +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070001 ! aspartic-type peptidase activity + +[Term] +id: GO:0004191 +name: obsolete barrierpepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] +comment: This term was made obsolete because it represents a gene product. +synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] +synonym: "barrier proteinase activity" RELATED [EC:3.4.23.35] +synonym: "barrierpepsin activity" EXACT [] +synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004192 +name: obsolete cathepsin D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin D activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004193 +name: obsolete cathepsin E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin D-like acid proteinase activity" RELATED [EC:3.4.23.34] +synonym: "cathepsin D-type proteinase activity" RELATED [EC:3.4.23.34] +synonym: "cathepsin E activity" EXACT [] +synonym: "cathepsin E-like acid proteinase activity" RELATED [EC:3.4.23.34] +synonym: "EMAP" RELATED [EC:3.4.23.34] +synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] +synonym: "non-pepsin proteinase activity" RELATED [EC:3.4.23.34] +synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] +synonym: "SMP" RELATED [EC:3.4.23.34] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004194 +name: obsolete pepsin A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] +synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] +synonym: "lactated pepsin" RELATED [EC:3.4.23.1] +synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] +synonym: "P I" RELATED [EC:3.4.23.1] +synonym: "P II" RELATED [EC:3.4.23.1] +synonym: "pepsin A activity" EXACT [] +synonym: "pepsin activity" BROAD [EC:3.4.23.1] +synonym: "pepsin D" RELATED [EC:3.4.23.1] +synonym: "pepsin fortior" RELATED [EC:3.4.23.1] +synonym: "pepsin R" RELATED [EC:3.4.23.1] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004195 +name: obsolete renin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] +comment: This term was made obsolete because it represents a gene product. +synonym: "angiotensin-forming enzyme activity" RELATED [EC:3.4.23.15] +synonym: "angiotensinogenase activity" RELATED [EC:3.4.23.15] +synonym: "renin activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004196 +name: obsolete saccharopepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] +comment: This term was made obsolete because it represents a gene product. +synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] +synonym: "PRA" RELATED [EC:3.4.23.25] +synonym: "proteinase A" RELATED [EC:3.4.23.25] +synonym: "proteinase yscA" RELATED [EC:3.4.23.25] +synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] +synonym: "saccharomyces aspartic proteinase activity" RELATED [EC:3.4.23.25] +synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] +synonym: "saccharopepsin activity" EXACT [] +synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] +synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0004197 +name: cysteine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] +synonym: "caspase activity" NARROW [GOC:mtg_apoptosis] +synonym: "lysosomal cysteine-type endopeptidase" NARROW [] +synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] +synonym: "thiol endopeptidase activity" EXACT [] +xref: EC:3.4.22.- +xref: Reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome" +xref: Reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9" +xref: Reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome" +xref: Reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle" +xref: Reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage" +xref: Reactome:R-HSA-139952 "Caspase-8 processing in the DISC" +xref: Reactome:R-HSA-1678920 "TLR processing at low pH" +xref: Reactome:R-HSA-1678981 "TLR9 processing at neutral pH" +xref: Reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1" +xref: Reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta" +xref: Reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin" +xref: Reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1" +xref: Reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin" +xref: Reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)" +xref: Reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau" +xref: Reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus" +xref: Reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3" +xref: Reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1" +xref: Reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin" +xref: Reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1" +xref: Reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2" +xref: Reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha" +xref: Reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3" +xref: Reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3" +xref: Reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1" +xref: Reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin" +xref: Reactome:R-HSA-202947 "Caspase mediated cleavage of APC" +xref: Reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1" +xref: Reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55" +xref: Reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin" +xref: Reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin" +xref: Reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3" +xref: Reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)" +xref: Reactome:R-HSA-211651 "Cleavage of PAK-2 at 212" +xref: Reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta" +xref: Reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22" +xref: Reactome:R-HSA-2130349 "Generation of CLIP from lip10" +xref: Reactome:R-HSA-2130504 "Cleavage of lip22 to lip10" +xref: Reactome:R-HSA-2130706 "MHC class II antigen processing" +xref: Reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex" +xref: Reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A" +xref: Reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1" +xref: Reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC" +xref: Reactome:R-HSA-350158 "LGMN degrades GC" +xref: Reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)" +xref: Reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)" +xref: Reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK" +xref: Reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk" +xref: Reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2" +xref: Reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin" +xref: Reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2" +xref: Reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31" +xref: Reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3" +xref: Reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1" +xref: Reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin" +xref: Reactome:R-HSA-352268 "Cleavage of Satb1" +xref: Reactome:R-HSA-418845 "Activation of caspase-3" +xref: Reactome:R-HSA-418846 "Caspase cleavage of UNC5A" +xref: Reactome:R-HSA-418852 "Caspase cleavage of UNC5B" +xref: Reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1" +xref: Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8" +xref: Reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases" +xref: Reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor" +xref: Reactome:R-HSA-5681987 "LC3 is cleaved by ATG4" +xref: Reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4" +xref: Reactome:R-HSA-6814387 "CASP14 cleaves filaggrin" +xref: Reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37" +xref: Reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex" +xref: Reactome:R-HSA-933532 "Processing of caspases" +xref: Reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3" +xref: Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins" +xref: Reactome:R-HSA-9684273 "3CLp cleaves pp1a" +xref: Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11" +xref: Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4" +xref: Reactome:R-HSA-9684336 "nsp1-4 cleaves itself" +xref: Reactome:R-HSA-9684340 "3CLp cleaves pp1ab" +xref: Reactome:R-HSA-9684351 "pp1a cleaves itself" +xref: Reactome:R-HSA-9684352 "nsp3-4 cleaves itself" +xref: Reactome:R-HSA-9686930 "RIPK3 is cleaved by CASP8" +xref: Reactome:R-HSA-9693929 "RIPK1 variant is not cleaved by CASP8" +xref: Reactome:R-HSA-9694338 "nsp1-4 cleaves itself" +xref: Reactome:R-HSA-9694377 "pp1a cleaves itself" +xref: Reactome:R-HSA-9694441 "3CLp cleaves pp1a" +xref: Reactome:R-HSA-9694551 "3CLp cleaves nsp6-11" +xref: Reactome:R-HSA-9694601 "nsp3-4 cleaves itself" +xref: Reactome:R-HSA-9694625 "nsp3 cleaves nsp1-4" +xref: Reactome:R-HSA-9694732 "3CLp cleaves pp1ab" +xref: Reactome:R-HSA-9697750 "RIPK1 is cleaved by CASP8:FLIP(L)" +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008234 ! cysteine-type peptidase activity + +[Term] +id: GO:0004198 +name: calcium-dependent cysteine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] +synonym: "calpain activity" NARROW [] +xref: Reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins" +xref: Reactome:R-HSA-8863012 "Calpain cleaves p35 to p25" +is_a: GO:0004197 ! cysteine-type endopeptidase activity + +[Term] +id: GO:0004200 +name: obsolete signaling (initiator) caspase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes biological process information. +synonym: "signaling (initiator) caspase activity" EXACT [] +synonym: "signalling (initiator) caspase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 +consider: GO:0006915 + +[Term] +id: GO:0004201 +name: obsolete caspase-1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-1 activity" EXACT [] +synonym: "ICE" BROAD [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004202 +name: obsolete caspase-2 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-2 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004203 +name: obsolete caspase-4 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-4 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004204 +name: obsolete caspase-5 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-5 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004205 +name: obsolete caspase-8 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-8 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004206 +name: obsolete caspase-10 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-10 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004207 +name: obsolete effector caspase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes biological process information. +synonym: "effector caspase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 +consider: GO:0006915 + +[Term] +id: GO:0004208 +name: obsolete caspase-3 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-3 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004209 +name: obsolete caspase-6 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-6 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004210 +name: obsolete caspase-7 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-7 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004211 +name: obsolete caspase-9 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase-9 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004212 +name: obsolete lysosomal cysteine-type endopeptidase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "lysosomal cysteine-type endopeptidase" EXACT [] +is_obsolete: true +consider: GO:0004197 +consider: GO:0005764 + +[Term] +id: GO:0004213 +name: obsolete cathepsin B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin B activity" EXACT [] +synonym: "cathepsin B1 activity" RELATED [EC:3.4.22.1] +synonym: "cathepsin II" RELATED [EC:3.4.22.1] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004214 +name: obsolete dipeptidyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin C activity" RELATED [EC:3.4.14.1] +synonym: "cathepsin J activity" RELATED [EC:3.4.14.1] +synonym: "DAP I" RELATED [EC:3.4.14.1] +synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] +synonym: "dipeptidyl aminopeptidase I activity" RELATED [EC:3.4.14.1] +synonym: "dipeptidyl transferase activity" RELATED [EC:3.4.14.1] +synonym: "dipeptidyl-peptidase I activity" EXACT [] +xref: EC:3.4.14.1 +xref: MetaCyc:3.4.14.1-RXN +is_obsolete: true +consider: GO:0008234 +consider: GO:0008239 + +[Term] +id: GO:0004215 +name: obsolete cathepsin H activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] +comment: This term was made obsolete because it represents a gene product. +synonym: "aleurain activity" RELATED [EC:3.4.22.16] +synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" RELATED [EC:3.4.22.16] +synonym: "cathepsin B3 activity" RELATED [EC:3.4.22.16] +synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] +synonym: "cathepsin BA activity" RELATED [EC:3.4.22.16] +synonym: "cathepsin H activity" EXACT [] +synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" RELATED [EC:3.4.22.16] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004216 +name: obsolete cathepsin K activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin K activity" EXACT [] +synonym: "cathepsin O activity" RELATED [EC:3.4.22.38] +synonym: "cathepsin O2 activity" RELATED [EC:3.4.22.38] +synonym: "cathepsin X activity" RELATED [EC:3.4.22.38] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004217 +name: obsolete cathepsin L activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] +comment: This term was made obsolete because it represents a gene product. +synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] +synonym: "cathepsin L activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004218 +name: obsolete cathepsin S activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin S activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0004219 +name: obsolete pyroglutamyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "5-oxoprolyl-peptidase activity" RELATED [EC:3.4.19.3] +synonym: "L-pyroglutamyl peptide hydrolase activity" RELATED [EC:3.4.19.3] +synonym: "L-pyrrolidonecarboxylate peptidase activity" RELATED [EC:3.4.19.3] +synonym: "PYRase activity" RELATED [EC:3.4.19.3] +synonym: "pyroglutamate aminopeptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyroglutamidase activity" RELATED [EC:3.4.19.3] +synonym: "pyroglutamyl aminopeptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyroglutamyl-peptidase I activity" EXACT [] +synonym: "pyrrolidone carboxyl peptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyrrolidone-carboxyl peptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyrrolidone-carboxylate peptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyrrolidonecarboxylyl peptidase activity" RELATED [EC:3.4.19.3] +synonym: "pyrrolidonyl peptidase activity" RELATED [EC:3.4.19.3] +xref: EC:3.4.19.3 +xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN +is_obsolete: true +consider: GO:0008234 +consider: GO:0016920 + +[Term] +id: GO:0004221 +name: obsolete ubiquitin thiolesterase activity +namespace: molecular_function +alt_id: GO:0008577 +def: "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] +comment: This term was made obsolete because this molecular function does not exist. +synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] +synonym: "ubiquitin carboxy-terminal esterase activity" RELATED [EC:3.1.2.15] +synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] +synonym: "ubiquitin thioesterase activity" RELATED [EC:3.1.2.15] +synonym: "ubiquitin thiolesterase activity" EXACT [] +synonym: "ubiquitin-C-terminal-thioester hydrolase activity" RELATED [EC:3.1.2.15] +synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] +xref: KEGG_REACTION:R02418 +xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN +is_obsolete: true +consider: GO:0004843 + +[Term] +id: GO:0004222 +name: metalloendopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] +synonym: "metalloendoprotease activity" NARROW [GOC:mah] +synonym: "metalloendoproteinase activity" NARROW [GOC:mah] +xref: EC:3.4.24.- +xref: Reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR" +xref: Reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17" +xref: Reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors" +xref: Reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors" +xref: Reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" +xref: Reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2" +xref: Reactome:R-HSA-1458433 "Collagen type I degradation by MMP14" +xref: Reactome:R-HSA-1474196 "Collagen type II degradation by MMP14" +xref: Reactome:R-HSA-1474210 "Collagen type III degradation by MMP14" +xref: Reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13" +xref: Reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11" +xref: Reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13" +xref: Reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3" +xref: Reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12" +xref: Reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2" +xref: Reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10" +xref: Reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1" +xref: Reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9" +xref: Reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13" +xref: Reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs" +xref: Reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2" +xref: Reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF" +xref: Reactome:R-HSA-181567 "botC LC cleaves target cell STX1" +xref: Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25" +xref: Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2" +xref: Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25" +xref: Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1" +xref: Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1" +xref: Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25" +xref: Reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides" +xref: Reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides" +xref: Reactome:R-HSA-2022141 "Prolysyl oxidase activation" +xref: Reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12" +xref: Reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9" +xref: Reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF" +xref: Reactome:R-HSA-2473584 "Collagen type III degradation by MMP15" +xref: Reactome:R-HSA-2473594 "Collagen type II degradation by MMP15" +xref: Reactome:R-HSA-2473596 "Collagen type I degradation by MMP15" +xref: Reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13" +xref: Reactome:R-HSA-2485111 "Collagen type III degradation by MMP10" +xref: Reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13" +xref: Reactome:R-HSA-2514790 "Elastin degradation by MMP14" +xref: Reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14" +xref: Reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14" +xref: Reactome:R-HSA-2533944 "Fibronectin degradation by MMP10" +xref: Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6" +xref: Reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15" +xref: Reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7" +xref: Reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15" +xref: Reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7" +xref: Reactome:R-HSA-2537499 "Gelatin degradation by MMP19" +xref: Reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1" +xref: Reactome:R-HSA-3371385 "TNF-alpha is cleaved by ADAM17 (TACE)" +xref: Reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5" +xref: Reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19" +xref: Reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14" +xref: Reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13" +xref: Reactome:R-HSA-3791319 "NID1 degradation by MMP19" +xref: Reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS" +xref: Reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4" +xref: Reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS" +xref: Reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7" +xref: Reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14" +xref: Reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7" +xref: Reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)" +xref: Reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15" +xref: Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2" +xref: Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2" +xref: Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2" +xref: Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2" +xref: Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1" +xref: Reactome:R-HSA-5333671 "CLCAs self cleave" +xref: Reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding" +xref: Reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3" +xref: Reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)" +xref: Reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1" +xref: Reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2" +xref: Reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3" +xref: Reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1" +xref: Reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4" +xref: Reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3" +xref: Reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)" +xref: Reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)" +xref: Reactome:R-HSA-8940554 "MMP2 cleaves OPTC" +xref: Reactome:R-HSA-8940561 "MMP7 cleaves OPTC" +xref: Reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)" +xref: Reactome:R-HSA-8940959 "Neurolysin degrades neurotensin" +xref: Reactome:R-HSA-8942302 "MMP13 cleaves OPTC" +xref: Reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3" +xref: Reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)" +xref: Reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU" +xref: Reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1" +xref: Reactome:R-HSA-9624272 "MMPs cleave HB-EGF" +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008237 ! metallopeptidase activity + +[Term] +id: GO:0004226 +name: obsolete Gly-X carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] +synonym: "carboxypeptidase S activity" RELATED [EC:3.4.17.4] +synonym: "Gly-X carboxypeptidase activity" EXACT [] +synonym: "Gly-Xaa carboxypeptidase activity" RELATED [EC:3.4.17.4] +synonym: "glycine carboxypeptidase activity" RELATED [EC:3.4.17.4] +synonym: "peptidase alpha" RELATED [EC:3.4.17.4] +synonym: "yeast carboxypeptidase activity" RELATED [EC:3.4.17.4] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0004228 +name: obsolete gelatinase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "3/4 collagenase activity" RELATED [] +synonym: "72 kDa gelatinase type A" RELATED [] +synonym: "72-kDa gelatinase activity" NARROW [] +synonym: "collagenase IV" RELATED [] +synonym: "collagenase type IV" RELATED [] +synonym: "gelatinase A activity" EXACT [] +synonym: "matrix metalloproteinase 2 activity" RELATED [] +synonym: "matrix metalloproteinase 5" RELATED [] +synonym: "MMP 2" RELATED [] +synonym: "MMP-2" EXACT [] +synonym: "type IV collagen metalloproteinase" BROAD [] +synonym: "type IV collagenase activity" RELATED [] +synonym: "type IV collagenase/gelatinase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004229 +name: obsolete gelatinase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "92-kDa gelatinase activity" NARROW [] +synonym: "92-kDa type IV collagenase activity" NARROW [] +synonym: "95 kDa type IV collagenase/gelatinase activity" RELATED [] +synonym: "collagenase IV" RELATED [] +synonym: "collagenase type IV" RELATED [] +synonym: "gelatinase B activity" EXACT [] +synonym: "gelatinase MMP 9" RELATED [] +synonym: "macrophage gelatinase activity" NARROW [] +synonym: "matrix metalloproteinase 9 activity" RELATED [] +synonym: "MMP 9" RELATED [] +synonym: "MMP-9" EXACT [] +synonym: "type IV collagen metalloproteinase" BROAD [] +synonym: "type V collagenase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004230 +name: obsolete glutamyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] +synonym: "angiotensinase A" RELATED [EC:3.4.11.7] +synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] +synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] +synonym: "aspartate aminopeptidase activity" RELATED [EC:3.4.11.7] +synonym: "Ca2+-activated glutamate aminopeptidase activity" RELATED [EC:3.4.11.7] +synonym: "glutamyl aminopeptidase activity" EXACT [] +synonym: "glutamyl peptidase activity" RELATED [EC:3.4.11.7] +synonym: "L-aspartate aminopeptidase activity" RELATED [EC:3.4.11.7] +synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] +xref: EC:3.4.11.7 +xref: MetaCyc:3.4.11.7-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0004231 +name: obsolete insulysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "IDE" RELATED [] +synonym: "insulin protease activity" RELATED [] +synonym: "insulin proteinase activity" RELATED [] +synonym: "insulin-degrading enzyme activity" RELATED [] +synonym: "insulin-degrading neutral proteinase activity" RELATED [] +synonym: "insulin-glucagon protease activity" RELATED [] +synonym: "insulin-specific protease activity" RELATED [] +synonym: "insulinase activity" RELATED [] +synonym: "insulysin activity" EXACT [] +synonym: "metalloinsulinase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004232 +name: obsolete interstitial collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "interstitial collagenase activity" EXACT [] +synonym: "matrix metalloproteinase 1" EXACT [] +synonym: "MMP-1" EXACT [] +synonym: "vertebrate collagenase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004234 +name: obsolete macrophage elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] +comment: This term was made obsolete because it represents a gene product. +synonym: "human macrophage metalloelastase (HME)" RELATED [EC:3.4.24.65] +synonym: "macrophage elastase activity" EXACT [] +synonym: "matrix metalloproteinase 12 activity" RELATED [EC:3.4.24.65] +synonym: "metalloelastase activity" RELATED [EC:3.4.24.65] +synonym: "metalloesterase activity" EXACT [] +synonym: "MMP-12" EXACT [] +xref: EC:3.4.24.65 +xref: MetaCyc:3.4.24.65-RXN +is_obsolete: true +consider: GO:0004175 +consider: GO:0004222 + +[Term] +id: GO:0004235 +name: obsolete matrilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrilysin activity" EXACT [] +synonym: "matrin activity" RELATED [] +synonym: "matrix metalloproteinase 7 activity" RELATED [] +synonym: "matrix metalloproteinase pump 1" RELATED [] +synonym: "metalloproteinase pump-1" RELATED [] +synonym: "MMP" RELATED [] +synonym: "MMP 7" RELATED [] +synonym: "MMP-7" EXACT [] +synonym: "PUMP" RELATED [] +synonym: "PUMP-1 activity" NARROW [] +synonym: "PUMP-1 proteinase activity" RELATED [] +synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [] +synonym: "putative metalloproteinase activity" RELATED [] +synonym: "uterine metalloendopeptidase activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004237 +name: obsolete membrane dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminodipeptidase activity" RELATED [EC:3.4.13.19] +synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] +synonym: "dehydropeptidase I activity" RELATED [EC:3.4.13.19] +synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] +synonym: "dipeptidyl hydrolase activity" RELATED [EC:3.4.13.19] +synonym: "DPH I activity" NARROW [EC:3.4.13.19] +synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" RELATED [EC:3.4.13.19] +synonym: "MDP" RELATED [EC:3.4.13.19] +synonym: "membrane dipeptidase activity" EXACT [] +synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] +synonym: "nonspecific dipeptidase activity" RELATED [EC:3.4.13.19] +synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] +xref: EC:3.4.13.19 +xref: MetaCyc:3.4.13.19-RXN +is_obsolete: true +consider: GO:0008235 +consider: GO:0016805 + +[Term] +id: GO:0004238 +name: obsolete meprin A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "endopeptidase-2 activity" BROAD [] +synonym: "meprin" RELATED [] +synonym: "meprin A activity" EXACT [] +synonym: "meprin-a" RELATED [] +synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" RELATED [] +synonym: "PABA-peptide hydrolase activity" RELATED [] +synonym: "PPH" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004239 +name: obsolete methionyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] +comment: This term was made obsolete because it represents a gene product. +synonym: "L-methionine aminopeptidase activity" RELATED [EC:3.4.11.18] +synonym: "MAP" RELATED [EC:3.4.11.18] +synonym: "methionine aminopeptidase activity" RELATED [EC:3.4.11.18] +synonym: "methionyl aminopeptidase activity" EXACT [] +synonym: "peptidase M activity" RELATED [EC:3.4.11.18] +xref: EC:3.4.11.18 +xref: MetaCyc:3.4.11.18-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 +consider: GO:0070084 + +[Term] +id: GO:0004240 +name: obsolete mitochondrial processing peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-mitochondrial processing peptidase" NARROW [] +synonym: "beta-mitochondrial processing peptidase" NARROW [] +synonym: "matrix peptidase" RELATED [] +synonym: "matrix processing peptidase" RELATED [] +synonym: "matrix processing proteinase" RELATED [] +synonym: "mitochondrial processing peptidase activity" EXACT [] +synonym: "mitochondrial protein precursor-processing proteinase activity" RELATED [] +synonym: "MPP" EXACT [] +synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [] +synonym: "processing enhancing peptidase activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004241 +name: obsolete alpha-mitochondrial processing peptidase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-mitochondrial processing peptidase" EXACT [] +synonym: "alpha-MPP" EXACT [] +is_obsolete: true +consider: GO:0004222 +consider: GO:0005739 + +[Term] +id: GO:0004242 +name: obsolete beta-mitochondrial processing peptidase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "beta-mitochondrial processing peptidase" EXACT [] +synonym: "beta-MPP" EXACT [] +is_obsolete: true +consider: GO:0004222 +consider: GO:0005739 + +[Term] +id: GO:0004243 +name: obsolete mitochondrial intermediate peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "MIP" BROAD [] +synonym: "mitochondrial intermediate peptidase activity" EXACT [] +synonym: "mitochondrial intermediate precursor-processing proteinase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004244 +name: obsolete mitochondrial inner membrane peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] +comment: This term was made obsolete because it represents a gene product. +synonym: "IMP" BROAD [] +synonym: "mitochondrial inner membrane peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0004245 +name: obsolete neprilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [GOC:curator] +comment: This term was made obsolete because it represents a gene product. +synonym: "acute lymphoblastic leukemia antigen" RELATED [] +synonym: "CALLA" RELATED [] +synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [] +synonym: "CALLA antigen" RELATED [] +synonym: "CALLA glycoprotein" RELATED [] +synonym: "CALLA glycoproteins" RELATED [] +synonym: "CD10" RELATED [] +synonym: "common acute lymphoblastic leukemia antigen" RELATED [] +synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [] +synonym: "endopeptidase 24.11" RELATED [] +synonym: "endopeptidase-2 activity" BROAD [] +synonym: "enkephalinase activity" RELATED [] +synonym: "kidney-brush-border neutral endopeptidase" NARROW [] +synonym: "kidney-brush-border neutral peptidase" NARROW [] +synonym: "kidney-brush-border neutral proteinase activity" NARROW [] +synonym: "membrane metalloendopeptidase activity" NARROW [] +synonym: "neprilysin activity" EXACT [] +synonym: "neutral endopeptidase 24.11" RELATED [] +synonym: "neutral endopeptidase activity" RELATED [] +synonym: "neutral metallendopeptidase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004246 +name: obsolete peptidyl-dipeptidase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "ACE activity" BROAD [] +synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] +synonym: "angiotensin I-converting enzyme activity" RELATED [EC:3.4.15.1] +synonym: "carboxycathepsin activity" RELATED [EC:3.4.15.1] +synonym: "DCP" RELATED [EC:3.4.15.1] +synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] +synonym: "dipeptidyl carboxypeptidase I activity" RELATED [EC:3.4.15.1] +synonym: "endothelial cell peptidyl dipeptidase activity" RELATED [EC:3.4.15.1] +synonym: "kininase II activity" RELATED [EC:3.4.15.1] +synonym: "PDH" RELATED [EC:3.4.15.1] +synonym: "peptidase P activity" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptidase I activity" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] +synonym: "peptidyl dipeptide hydrolase activity" RELATED [EC:3.4.15.1] +synonym: "peptidyl-dipeptidase A activity" EXACT [] +synonym: "peptidyl-dipeptide hydrolase activity" RELATED [EC:3.4.15.1] +synonym: "peptidyldipeptide hydrolase activity" RELATED [EC:3.4.15.1] +xref: EC:3.4.15.1 +xref: MetaCyc:3.4.15.1-RXN +is_obsolete: true +consider: GO:0008237 +consider: GO:0008241 + +[Term] +id: GO:0004247 +name: obsolete saccharolysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "oligopeptidase yscD activity" NARROW [] +synonym: "proteinase yscD activity" NARROW [] +synonym: "saccharolysin activity" EXACT [] +synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [] +synonym: "yeast cysteine proteinase D activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004248 +name: obsolete stromelysin 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "collagen-activating protein" RELATED [] +synonym: "collagenase activating protein" RELATED [] +synonym: "matrix metalloproteinase 3 activity" RELATED [] +synonym: "MMP-3" EXACT [] +synonym: "neutral proteoglycanase activity" RELATED [] +synonym: "procollagenase activator" RELATED [] +synonym: "proteoglycanase activity" RELATED [] +synonym: "stromelysin" RELATED [] +synonym: "stromelysin 1 activity" EXACT [] +synonym: "transin activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004249 +name: obsolete stromelysin 3 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 11" EXACT [] +synonym: "MMP-11" EXACT [] +synonym: "stromelysin 3 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0004250 +name: obsolete aminopeptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminopeptidase I activity" EXACT [] +synonym: "aminopeptidase III activity" RELATED [EC:3.4.11.22] +synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] +synonym: "leucine aminopeptidase IV activity" RELATED [EC:3.4.11.22] +synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] +synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] +xref: EC:3.4.11.22 +xref: MetaCyc:3.4.11.22-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0004251 +name: obsolete X-Pro dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "gamma-peptidase activity" RELATED [EC:3.4.13.9] +synonym: "imidodipeptidase activity" RELATED [EC:3.4.13.9] +synonym: "peptidase D" RELATED [EC:3.4.13.9] +synonym: "prolidase activity" RELATED [EC:3.4.13.9] +synonym: "proline dipeptidase activity" RELATED [EC:3.4.13.9] +synonym: "X-Pro dipeptidase activity" EXACT [] +synonym: "Xaa-Pro dipeptidase activity" EXACT [] +xref: EC:3.4.13.9 +xref: MetaCyc:3.4.13.9-RXN +is_obsolete: true +consider: GO:0008235 +consider: GO:0016805 + +[Term] +id: GO:0004252 +name: serine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +subset: goslim_chembl +synonym: "blood coagulation factor activity" RELATED [] +synonym: "serine elastase activity" RELATED [GOC:krc] +xref: EC:3.4.21.- +xref: Reactome:R-HSA-114697 "Thrombin-mediated activation of Proteinase-activated receptors" +xref: Reactome:R-HSA-1181152 "Cleavage of NODAL proprotein" +xref: Reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage" +xref: Reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides" +xref: Reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)" +xref: Reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide" +xref: Reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)" +xref: Reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)" +xref: Reactome:R-HSA-140769 "factor VII -> factor VIIa" +xref: Reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)" +xref: Reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)" +xref: Reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B" +xref: Reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin" +xref: Reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form" +xref: Reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C" +xref: Reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin." +xref: Reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2" +xref: Reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases" +xref: Reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases" +xref: Reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS" +xref: Reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer" +xref: Reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)" +xref: Reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)" +xref: Reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin" +xref: Reactome:R-HSA-158313 "factor XII -> factor XIIa" +xref: Reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)" +xref: Reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)" +xref: Reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin" +xref: Reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)" +xref: Reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin" +xref: Reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)" +xref: Reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)" +xref: Reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR" +xref: Reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)" +xref: Reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE" +xref: Reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2" +xref: Reactome:R-HSA-1592297 "Full activation of MMP1" +xref: Reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)" +xref: Reactome:R-HSA-1592316 "Initial activation of proMMP1" +xref: Reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3" +xref: Reactome:R-HSA-1592371 "Initial activation of proMMP3" +xref: Reactome:R-HSA-1592398 "Activation of proMMP8" +xref: Reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs" +xref: Reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin" +xref: Reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X" +xref: Reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C" +xref: Reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S" +xref: Reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX" +xref: Reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII" +xref: Reactome:R-HSA-1602458 "Activation of proMMP10" +xref: Reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN" +xref: Reactome:R-HSA-1602473 "Autocatalytic activation of MMP1" +xref: Reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN" +xref: Reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin" +xref: Reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7" +xref: Reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14" +xref: Reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2" +xref: Reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs" +xref: Reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin" +xref: Reactome:R-HSA-1604722 "Activation of proMMP9 by proteases" +xref: Reactome:R-HSA-1604731 "Autocatalytic activation of MMP3" +xref: Reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13" +xref: Reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)" +xref: Reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3" +xref: Reactome:R-HSA-1604763 "Autocatalytic activation of MMP7" +xref: Reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z" +xref: Reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6" +xref: Reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2" +xref: Reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b" +xref: Reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b" +xref: Reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases" +xref: Reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by furin" +xref: Reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein" +xref: Reactome:R-HSA-173626 "Activation of C1r" +xref: Reactome:R-HSA-173631 "Activation of C1s" +xref: Reactome:R-HSA-173680 "Activation of C5" +xref: Reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B" +xref: Reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase" +xref: Reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein" +xref: Reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B" +xref: Reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a" +xref: Reactome:R-HSA-186785 "PDGF-AA clevage by Furin" +xref: Reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF" +xref: Reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH" +xref: Reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN" +xref: Reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" +xref: Reactome:R-HSA-2129357 "Fibrillin C-terminal processing" +xref: Reactome:R-HSA-2168923 "Collagen type XVIII endostatin release" +xref: Reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding" +xref: Reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding" +xref: Reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1" +xref: Reactome:R-HSA-2471621 "Endostatin degradation by cathepsins" +xref: Reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding" +xref: Reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE" +xref: Reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2" +xref: Reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE" +xref: Reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS" +xref: Reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)" +xref: Reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1" +xref: Reactome:R-HSA-265301 "Corticotropin cleavage from POMC" +xref: Reactome:R-HSA-3266557 "Factor I cleaves iC3b" +xref: Reactome:R-HSA-3785684 "Fibronectin degradation by CTSG" +xref: Reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8" +xref: Reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)" +xref: Reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS" +xref: Reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS" +xref: Reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS" +xref: Reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1" +xref: Reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS" +xref: Reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1" +xref: Reactome:R-HSA-382061 "Extracellular processing of novel PDGFs" +xref: Reactome:R-HSA-3928657 "MMP2,9 cleave EPHB" +xref: Reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1" +xref: Reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP" +xref: Reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP" +xref: Reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin" +xref: Reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin" +xref: Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)" +xref: Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)" +xref: Reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)" +xref: Reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va" +xref: Reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa" +xref: Reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein" +xref: Reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer" +xref: Reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer" +xref: Reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer" +xref: Reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)" +xref: Reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP" +xref: Reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5" +xref: Reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2" +xref: Reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8" +xref: Reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5" +xref: Reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)" +xref: Reactome:R-HSA-8865275 "PDGF-BB clevage by Furin" +xref: Reactome:R-HSA-8865276 "PDGF-AB clevage by Furin" +xref: Reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4" +xref: Reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3" +xref: Reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2" +xref: Reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3" +xref: Reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1" +xref: Reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))" +xref: Reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)" +xref: Reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" +xref: Reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" +xref: Reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" +xref: Reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" +xref: Reactome:R-HSA-9033490 "TYSND1 cleaves PHYH" +xref: Reactome:R-HSA-9033506 "TYSND1 cleaves AGPS" +xref: Reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1" +xref: Reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1" +xref: Reactome:R-HSA-9033524 "TYSND1 cleaves SCP2" +xref: Reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1" +xref: Reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4" +xref: Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin" +xref: Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1" +xref: Reactome:R-HSA-9662786 "FURIN cleaves ADAM17" +xref: Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin" +xref: Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L" +xref: Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa" +xref: Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa" +xref: Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)" +xref: Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2" +xref: Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis" +xref: Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2" +xref: Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis" +xref: Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis" +xref: Reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b" +xref: Reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b" +xref: Reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0008236 ! serine-type peptidase activity + +[Term] +id: GO:0004253 +name: obsolete gamma-renin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "gamma-renin activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004254 +name: obsolete acylaminoacyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [GOC:curators] +synonym: "acylamino-acid-releasing enzyme activity" RELATED [] +synonym: "acylaminoacyl-peptidase activity" EXACT [] +synonym: "alpha-N-acylpeptide hydrolase activity" RELATED [EC:3.4.19.1] +synonym: "N-acylpeptide hydrolase activity" RELATED [] +synonym: "N-formylmethionine (fMet) aminopeptidase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004258 +name: obsolete vacuolar carboxypeptidase Y +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] +comment: This term was made obsolete because it contains both component and function information. +synonym: "vacuolar carboxypeptidase Y" EXACT [] +is_obsolete: true +consider: GO:0004185 +consider: GO:0005773 + +[Term] +id: GO:0004261 +name: obsolete cathepsin G activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin G activity" EXACT [] +synonym: "chymotrypsin-like proteinase activity" RELATED [] +synonym: "neutral proteinase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004262 +name: obsolete cerevisin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "baker's yeast proteinase B" RELATED [] +synonym: "brewer's yeast proteinase" NARROW [] +synonym: "cerevisin activity" EXACT [] +synonym: "peptidase beta" RELATED [] +synonym: "proteinase yscB activity" NARROW [] +synonym: "yeast proteinase B activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004263 +name: obsolete chymotrypsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-chymar" RELATED [] +synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] +synonym: "alpha-chymotrypsin A" RELATED [] +synonym: "alpha-chymotrypsin activity" NARROW [] +synonym: "avazyme" RELATED [] +synonym: "chymar" RELATED [] +synonym: "chymotest" RELATED [] +synonym: "chymotrypsin A activity" NARROW [] +synonym: "chymotrypsin activity" EXACT [] +synonym: "chymotrypsin B activity" NARROW [] +synonym: "chymotrypsins A and B" RELATED [] +synonym: "enzeon" RELATED [] +synonym: "quimar" RELATED [] +synonym: "quimotrase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004274 +name: obsolete dipeptidyl-peptidase IV activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl aminopeptidase IV activity" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] +synonym: "dipeptidyl-peptidase IV activity" EXACT [] +synonym: "dipeptidyl-peptide hydrolase activity" RELATED [EC:3.4.14.5] +synonym: "DPP IV activity" RELATED [EC:3.4.14.5] +synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] +synonym: "Gly-Pro naphthylamidase activity" RELATED [EC:3.4.14.5] +synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] +synonym: "glycylproline aminopeptidase activity" RELATED [EC:3.4.14.5] +synonym: "glycylprolyl aminopeptidase activity" RELATED [EC:3.4.14.5] +synonym: "glycylprolyl dipeptidylaminopeptidase activity" RELATED [EC:3.4.14.5] +synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] +synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] +synonym: "pep X" RELATED [EC:3.4.14.5] +synonym: "post-proline dipeptidyl aminopeptidase IV activity" RELATED [EC:3.4.14.5] +synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] +synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] +synonym: "X-PDAP" RELATED [EC:3.4.14.5] +synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" RELATED [EC:3.4.14.5] +synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" RELATED [EC:3.4.14.5] +xref: EC:3.4.14.5 +xref: MetaCyc:3.4.14.5-RXN +is_obsolete: true +consider: GO:0008236 +consider: GO:0008239 + +[Term] +id: GO:0004275 +name: obsolete enteropeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "enterokinase activity" RELATED [] +synonym: "enteropeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004276 +name: obsolete furin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "dibasic processing enzyme activity" RELATED [] +synonym: "furin activity" EXACT [] +synonym: "PACE" RELATED [] +synonym: "paired basic amino acid cleaving enzyme" RELATED [] +synonym: "paired basic amino acid converting enzyme" RELATED [] +synonym: "paired basic amino acid residue cleaving enzyme activity" RELATED [] +synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] +synonym: "serine proteinase PACE" RELATED [] +synonym: "SPC3" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004277 +name: obsolete granzyme A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "CTLA3" RELATED [] +synonym: "cytotoxic T lymphocyte serine protease" NARROW [] +synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [] +synonym: "granzyme A activity" EXACT [] +synonym: "HuTPS" RELATED [] +synonym: "T-cell associated protease 1" RELATED [] +synonym: "T-cell derived serine proteinase" NARROW [] +synonym: "TSP-1" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004278 +name: obsolete granzyme B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "CCP1 proteinase" NARROW [] +synonym: "CCPII" RELATED [] +synonym: "CTLA1" RELATED [] +synonym: "cytotoxic cell proteinase-1" RELATED [] +synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [] +synonym: "granzyme B activity" EXACT [] +synonym: "granzyme G" RELATED [] +synonym: "granzyme H" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004281 +name: obsolete pancreatic elastase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "pancreatic elastase 2" RELATED [] +synonym: "pancreatic elastase II activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004283 +name: obsolete plasmin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "actase activity" RELATED [] +synonym: "fibrinase activity" RELATED [] +synonym: "fibrinolysin activity" RELATED [] +synonym: "plasmin activity" EXACT [] +synonym: "serum tryptase activity" RELATED [] +synonym: "thrombolysin" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004284 +name: obsolete acrosin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "acrosin activity" EXACT [] +synonym: "acrosin amidase activity" RELATED [] +synonym: "acrosomal protease activity" RELATED [] +synonym: "acrosomal proteinase activity" RELATED [] +synonym: "acrozonase activity" RELATED [] +synonym: "alpha-acrosin" RELATED [] +synonym: "beta-acrosin" RELATED [] +synonym: "psi-acrosin" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004285 +name: obsolete proprotein convertase 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "NEC 1 activity" NARROW [] +synonym: "neuroendocrine convertase 1 activity" NARROW [] +synonym: "PC1 activity" NARROW [] +synonym: "prohormone convertase 3" RELATED [] +synonym: "prohormone convertase I activity" NARROW [] +synonym: "proprotein convertase 1 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004286 +name: obsolete proprotein convertase 2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "NEC 2 activity" NARROW [] +synonym: "neuroendocrine convertase 2 activity" NARROW [] +synonym: "PC2 activity" NARROW [] +synonym: "prohormone convertase II activity" NARROW [] +synonym: "proprotein convertase 2 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004287 +name: obsolete prolyl oligopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "endoprolylpeptidase activity" RELATED [] +synonym: "post-proline cleaving enzyme activity" RELATED [] +synonym: "post-proline endopeptidase activity" RELATED [] +synonym: "proline endopeptidase activity" RELATED [] +synonym: "proline-specific endopeptidase activity" RELATED [] +synonym: "prolyl endopeptidase activity" RELATED [] +synonym: "prolyl oligopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004289 +name: obsolete subtilase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "subtilase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004290 +name: obsolete kexin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "andrenorphin-Gly-generating enzyme" RELATED [] +synonym: "endoproteinase Kex2p" RELATED [] +synonym: "gene KEX2 dibasic proteinase" NARROW [] +synonym: "Kex 2p proteinase" NARROW [] +synonym: "Kex2 endopeptidase" NARROW [] +synonym: "Kex2 endoprotease" NARROW [] +synonym: "Kex2 endoproteinase" NARROW [] +synonym: "Kex2 protease" NARROW [] +synonym: "Kex2 proteinase" NARROW [] +synonym: "Kex2-like endoproteinase" NARROW [] +synonym: "Kex2-like precursor protein processing endoprotease" NARROW [] +synonym: "kexin activity" EXACT [] +synonym: "paired-basic endopeptidase activity" RELATED [] +synonym: "prohormone-processing endoprotease activity" RELATED [] +synonym: "prohormone-processing KEX2 proteinase" NARROW [] +synonym: "prohormone-processing proteinase activity" RELATED [] +synonym: "protease KEX2" RELATED [] +synonym: "proteinase Kex2p" RELATED [] +synonym: "proteinase yscF activity" NARROW [] +synonym: "yeast cysteine proteinase F" RELATED [] +synonym: "yeast KEX2 protease activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004291 +name: obsolete subtilisin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "alcalase 0.6L" RELATED [] +synonym: "alcalase 2.5L" RELATED [] +synonym: "alcalase activity" RELATED [] +synonym: "ALK-enzyme" RELATED [] +synonym: "bacillopeptidase A" RELATED [] +synonym: "bacillopeptidase B" RELATED [] +synonym: "bacillus subtilis alkaline proteinase activity" RELATED [] +synonym: "bacillus subtilis alkaline proteinase bioprase activity" RELATED [] +synonym: "bioprase AL 15" RELATED [] +synonym: "bioprase APL 30" RELATED [] +synonym: "colistinase activity" RELATED [] +synonym: "esperase activity" RELATED [] +synonym: "genenase I" RELATED [] +synonym: "kazusase activity" RELATED [] +synonym: "maxatase activity" RELATED [] +synonym: "opticlean" RELATED [] +synonym: "orientase 10B" RELATED [] +synonym: "protease S" RELATED [] +synonym: "protease VIII" RELATED [] +synonym: "protease XXVII" RELATED [] +synonym: "protin A 3L" RELATED [] +synonym: "savinase 16.0L" RELATED [] +synonym: "savinase 32.0 L EX" RELATED [] +synonym: "savinase 4.0T" RELATED [] +synonym: "savinase 8.0L" RELATED [] +synonym: "savinase activity" RELATED [] +synonym: "SP 266" RELATED [] +synonym: "subtilisin activity" EXACT [] +synonym: "subtilisin BL" RELATED [] +synonym: "subtilisin DY" RELATED [] +synonym: "subtilisin E" RELATED [] +synonym: "subtilisin GX" RELATED [] +synonym: "subtilisin J" RELATED [] +synonym: "subtilisin S41" RELATED [] +synonym: "subtilisin sendai" RELATED [] +synonym: "subtilopeptidase activity" RELATED [] +synonym: "superase activity" RELATED [] +synonym: "thermoase" BROAD [] +synonym: "thermoase PC 10" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004293 +name: obsolete tissue kallikrein activity +namespace: molecular_function +alt_id: GO:0004279 +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "bradykininogenase" BROAD [] +synonym: "callicrein" RELATED [] +synonym: "depot-padutin" RELATED [] +synonym: "dilminal D" RELATED [] +synonym: "glandular kallikrein activity" RELATED [] +synonym: "glumorin" RELATED [] +synonym: "kallidinogenase" BROAD [] +synonym: "kidney kallikrein" RELATED [] +synonym: "kininogenase" BROAD [] +synonym: "kininogenin activity" RELATED [] +synonym: "onokrein P" RELATED [] +synonym: "padreatin" RELATED [] +synonym: "padutin" RELATED [] +synonym: "pancreatic kallikrein" RELATED [] +synonym: "salivary kallikrein" RELATED [] +synonym: "submandibular kallikrein" RELATED [] +synonym: "submaxillary kallikrein" RELATED [] +synonym: "tissue kallikrein activity" EXACT [] +synonym: "urinary kallikrein" RELATED [] +synonym: "urokallikrein" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004294 +name: obsolete tripeptidyl-peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] +comment: This term was made obsolete because it represents a gene product. +synonym: "TPP" RELATED [EC:3.4.14.10] +synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] +synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] +synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] +synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] +synonym: "tripeptidyl-peptidase II activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008240 + +[Term] +id: GO:0004295 +name: obsolete trypsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-trypsin activity" NARROW [] +synonym: "beta-trypsin activity" NARROW [] +synonym: "cocoonase activity" RELATED [] +synonym: "parenzyme" RELATED [] +synonym: "parenzymol" RELATED [EC:3.4.21.4] +synonym: "pseudotrypsin" RELATED [] +synonym: "sperm receptor hydrolase activity" RELATED [] +synonym: "tripcellim" RELATED [] +synonym: "trypsin activity" EXACT [] +synonym: "tryptar" RELATED [] +synonym: "trypure" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0004298 +name: threonine-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] +synonym: "26S protease" RELATED [EC:3.4.25.-] +synonym: "alkaline protease" RELATED [EC:3.4.25.-] +synonym: "ingensin" RELATED [EC:3.4.25.-] +synonym: "large multicatalytic protease" NARROW [EC:3.4.25.-] +synonym: "lens neutral proteinase" NARROW [EC:3.4.25.-] +synonym: "MCP" RELATED [EC:3.4.25.-] +synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25.-] +synonym: "multicatalytic proteinase" NARROW [EC:3.4.25.-] +synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25.-] +synonym: "prosome" RELATED [EC:3.4.25.-] +synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25.-] +synonym: "threonine endopeptidase activity" EXACT [] +synonym: "tricorn protease" NARROW [EC:3.4.25.-] +synonym: "tricorn proteinase" NARROW [EC:3.4.25.-] +xref: EC:3.4.25.- +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity + +[Term] +id: GO:0004299 +name: obsolete proteasome endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] +comment: This term was made obsolete because it mentions a component term in the text string. +synonym: "multicatalytic endopeptidase" RELATED [] +synonym: "proteasome" RELATED [] +synonym: "proteasome endopeptidase activity" EXACT [] +synonym: "proteasome endopeptidase complex" RELATED [] +is_obsolete: true +consider: GO:0004175 +consider: GO:0008233 + +[Term] +id: GO:0004300 +name: enoyl-CoA hydratase activity +namespace: molecular_function +alt_id: GO:0016510 +def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] +synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.17] +synonym: "2-enoyl-CoA hydratase activity" RELATED [EC:4.2.1.17] +synonym: "2-octenoyl coenzyme A hydrase activity" RELATED [EC:4.2.1.17] +synonym: "acyl coenzyme A hydrase activity" RELATED [EC:4.2.1.17] +synonym: "beta-hydroxyacid dehydrase activity" RELATED [EC:4.2.1.17] +synonym: "beta-hydroxyacyl-CoA dehydrase activity" RELATED [EC:4.2.1.17] +synonym: "crotonyl hydrase activity" RELATED [EC:4.2.1.17] +synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] +synonym: "ECH" RELATED [EC:4.2.1.17] +synonym: "enol-CoA hydratase activity" RELATED [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydrase (L)" RELATED [EC:4.2.1.17] +synonym: "enoyl coenzyme A hydratase activity" RELATED [EC:4.2.1.17] +synonym: "enoyl hydrase activity" RELATED [EC:4.2.1.17] +synonym: "hydratase, enoyl coenzyme A" RELATED [EC:4.2.1.17] +synonym: "short chain enoyl coenzyme A hydratase activity" RELATED [EC:4.2.1.17] +synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] +synonym: "trans-2-enoyl-CoA hydratase activity" RELATED [EC:4.2.1.17] +synonym: "unsaturated acyl-CoA hydratase activity" RELATED [EC:4.2.1.17] +xref: EC:4.2.1.17 +xref: MetaCyc:ENOYL-COA-HYDRAT-RXN +xref: Reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA" +xref: Reactome:R-HSA-70870 "ECHS1 hydrates methacrylyl-CoA" +xref: Reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA" +xref: Reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA" +xref: Reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA" +xref: Reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA" +xref: Reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA" +xref: Reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA" +xref: Reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA" +xref: RHEA:16105 +xref: UM-BBD_enzymeID:e0014 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004301 +name: epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] +subset: goslim_chembl +synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] +synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] +synonym: "cytosolic epoxide hydrolase activity" RELATED [EC:3.3.2.10] +synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] +synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] +synonym: "sEH" RELATED [EC:3.3.2.10] +synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] +synonym: "trans-stilbene oxide hydrolase activity" RELATED [EC:3.3.2.10] +xref: EC:3.3.2.10 +xref: MetaCyc:3.3.2.10-RXN +xref: Reactome:R-HSA-2161961 "EET(1) is hydrolysed to DHET(1) by EPHX2" +xref: Reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1" +xref: Reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1" +xref: Reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2" +xref: Reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4" +xref: Reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1" +xref: Reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2" +xref: Reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4" +xref: Reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1" +xref: Reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1" +xref: Reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2" +xref: Reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA" +xref: Reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA" +xref: Reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA" +xref: RHEA:19037 +xref: UM-BBD_enzymeID:e0397 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0004303 +name: estradiol 17-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] +synonym: "17-beta-estradiol dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] +synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] +synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "17beta-estradiol dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "17beta-HSD" RELATED [EC:1.1.1.62] +synonym: "17beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] +synonym: "estradiol 17beta-dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "estradiol dehydrogenase activity" RELATED [EC:1.1.1.62] +synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" RELATED [EC:1.1.1.62] +synonym: "estrogen 17-oxidoreductase activity" RELATED [EC:1.1.1.62] +xref: EC:1.1.1.62 +xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1" +xref: Reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1" +xref: Reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)" +xref: Reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b" +xref: Reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)" +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004304 +name: estrone sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] +synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" RELATED [EC:2.8.2.4] +synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" RELATED [EC:2.8.2.4] +synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" RELATED [EC:2.8.2.4] +synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] +synonym: "estrogen sulphotransferase activity" RELATED [EC:2.8.2.4] +synonym: "estrone sulphotransferase activity" EXACT [] +synonym: "oestrogen sulphotransferase activity" RELATED [EC:2.8.2.4] +xref: EC:2.8.2.4 +xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-176664 "estrone + PAPS => estrone 3-sulfate + PAP" +xref: RHEA:15973 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0004305 +name: ethanolamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069] +synonym: "ATP:ethanolamine O-phosphotransferase activity" RELATED [EC:2.7.1.82] +synonym: "ethanolamine kinase (phosphorylating)" RELATED [EC:2.7.1.82] +synonym: "ethanolamine phosphokinase activity" RELATED [EC:2.7.1.82] +xref: EC:2.7.1.82 +xref: KEGG_REACTION:R01468 +xref: MetaCyc:ETHANOLAMINE-KINASE-RXN +xref: Reactome:R-HSA-1483222 "ETA is phosphorylated to PETA by CHK/ETNK" +xref: RHEA:13069 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004306 +name: ethanolamine-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] +synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" RELATED [EC:2.7.7.14] +synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" RELATED [EC:2.7.7.14] +synonym: "ET" RELATED [EC:2.7.7.14] +synonym: "ethanolamine phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.14] +synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] +synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] +xref: EC:2.7.7.14 +xref: MetaCyc:2.7.7.14-RXN +xref: Reactome:R-HSA-1483190 "PETA and CTP are condensed to CDP-ETA by PCY2" +xref: RHEA:24592 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0004307 +name: ethanolaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1, RHEA:32943] +synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.1] +synonym: "CDPethanolamine diglyceride phosphotransferase activity" RELATED [EC:2.7.8.1] +synonym: "diacylglycerol ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.1] +synonym: "EPT" RELATED [EC:2.7.8.1] +synonym: "phosphorylethanolamine-glyceride transferase activity" RELATED [EC:2.7.8.1] +xref: EC:2.7.8.1 +xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN +xref: Reactome:R-HSA-1482962 "CDP-ETA and DAG are converted to PE by CEPT1/EPT1" +xref: RHEA:32943 +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0004308 +name: exo-alpha-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] +synonym: "acetylneuraminidase activity" RELATED [EC:3.2.1.18] +synonym: "acetylneuraminyl hydrolase activity" RELATED [EC:3.2.1.18] +synonym: "alpha-neuraminidase activity" RELATED [EC:3.2.1.18] +synonym: "N-acylneuraminate glycohydrolase activity" RELATED [EC:3.2.1.18] +synonym: "neuraminidase activity" RELATED [EC:3.2.1.18] +synonym: "sialidase activity" RELATED [EC:3.2.1.18] +xref: EC:3.2.1.18 +xref: MetaCyc:3.2.1.18-RXN +xref: Reactome:R-HSA-1605723 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)" +xref: Reactome:R-HSA-1605724 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)" +xref: Reactome:R-HSA-1605768 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)" +xref: Reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid" +xref: Reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates" +xref: Reactome:R-HSA-4084999 "NEU1 hydrolyses Neu5Ac from glycoconjugates" +xref: Reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates" +xref: Reactome:R-HSA-4341669 "Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates" +xref: Reactome:R-HSA-9638120 "NEU4 hydrolyses Neu5Ac from glycoconjugates" +is_a: GO:0016997 ! alpha-sialidase activity + +[Term] +id: GO:0004309 +name: exopolyphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] +synonym: "acid phosphoanhydride phosphohydrolase activity" RELATED [EC:3.6.1.11] +synonym: "exopolypase activity" RELATED [EC:3.6.1.11] +synonym: "Gra-Pase activity" RELATED [EC:3.6.1.11] +synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] +synonym: "polyphosphate phosphohydrolase activity" RELATED [EC:3.6.1.11] +xref: EC:3.6.1.11 +xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN +xref: RHEA:21528 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004310 +name: farnesyl-diphosphate farnesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] +comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. +synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" RELATED [EC:2.5.1.21] +synonym: "presqualene synthase activity" RELATED [EC:2.5.1.21] +synonym: "presqualene-diphosphate synthase activity" RELATED [EC:2.5.1.21] +xref: EC:2.5.1.21 +xref: MetaCyc:2.5.1.21-RXN +xref: Reactome:R-HSA-191402 "Reduction of presqualene diphosphate to form squalene" +xref: Reactome:R-HSA-191405 "Two FPP molecules dimerize to form presqualene diphosphate" +is_a: GO:0004311 ! farnesyltranstransferase activity + +[Term] +id: GO:0004311 +name: farnesyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17653] +comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. +synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] +synonym: "geranylgeranyl pyrophosphate synthase activity" RELATED [EC:2.5.1.29] +synonym: "geranylgeranyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.29] +synonym: "geranylgeranyl-diphosphate synthase activity" RELATED [EC:2.5.1.29] +synonym: "geranylgeranyl-PP synthetase activity" RELATED [EC:2.5.1.29] +synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" RELATED [EC:2.5.1.29] +xref: EC:2.5.1.29 +xref: KEGG_REACTION:R02061 +xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN +xref: RHEA:17653 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004312 +name: fatty acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" RELATED [EC:2.3.1.85] +synonym: "fatty-acid synthase activity" EXACT [] +xref: EC:2.3.1.85 +xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN +xref: Reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O" +xref: RHEA:14993 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0004313 +name: [acyl-carrier-protein] S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [RHEA:41788] +synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] +synonym: "ACAT activity" BROAD [EC:2.3.1.38] +synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" RELATED [EC:2.3.1.38] +synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" RELATED [EC:2.3.1.38] +synonym: "ACP acetyltransferase activity" RELATED [EC:2.3.1.38] +synonym: "ACP S-acetyltransferase activity" EXACT [] +synonym: "ACPacetyltransferase activity" RELATED [EC:2.3.1.38] +synonym: "acyl-carrier-protein acetyltransferase activity" RELATED [EC:2.3.1.38] +synonym: "acyl-carrier-protein S-acetyltransferase activity" RELATED [EC:2.3.1.38] +synonym: "acyl-carrier-proteinacetyltransferase activity" RELATED [EC:2.3.1.38] +xref: EC:2.3.1.38 +xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN +xref: RHEA:41788 +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0004314 +name: [acyl-carrier-protein] S-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] +synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] +synonym: "ACP S-malonyltransferase activity" EXACT [] +synonym: "acyl carrier protein malonyltransferase activity" RELATED [EC:2.3.1.39] +synonym: "acyl carrier proteinmalonyltransferase activity" RELATED [EC:2.3.1.39] +synonym: "acyl-carrier-protein S-malonyltransferase activity" RELATED [EC:2.3.1.39] +synonym: "FabD" RELATED [EC:2.3.1.39] +synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39] +synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] +synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] +synonym: "malonyl-CoA-acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39] +synonym: "malonyl-CoA:ACP transacylase activity" RELATED [EC:2.3.1.39] +synonym: "malonyl-CoA:AcpM transacylase activity" RELATED [EC:2.3.1.39] +synonym: "malonyl-CoA:acyl carrier protein transacylase activity" RELATED [EC:2.3.1.39] +synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" RELATED [EC:2.3.1.39] +synonym: "MAT" RELATED [EC:2.3.1.39] +synonym: "MCAT activity" RELATED [EC:2.3.1.39] +xref: EC:2.3.1.39 +xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN +xref: Reactome:R-HSA-8933547 "MCAT transfers Mal from Mal-CoA to NDUFAB1" +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016419 ! S-malonyltransferase activity + +[Term] +id: GO:0004315 +name: 3-oxoacyl-[acyl-carrier-protein] synthase activity +namespace: molecular_function +alt_id: GO:0033817 +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [RHEA:22836] +synonym: "3-ketoacyl-acyl carrier protein synthase activity" RELATED [EC:2.3.1.41] +synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] +synonym: "3-oxoacyl-ACP synthase activity" EXACT [] +synonym: "3-oxoacyl-acyl carrier protein synthase I activity" NARROW [EC:2.3.1.179] +synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" RELATED [EC:2.3.1.41] +synonym: "3-oxoacyl:ACP synthase I" NARROW [EC:2.3.1.41] +synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" RELATED [EC:2.3.1.41] +synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" RELATED [EC:2.3.1.41] +synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl acyl carrier protein synthase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl synthetase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl-ACP synthase I activity" NARROW [EC:2.3.1.41] +synonym: "beta-ketoacyl-ACP synthase II activity" NARROW [EC:2.3.1.179] +synonym: "beta-ketoacyl-ACP synthetase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl carrier protein synthase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" RELATED [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" NARROW [EC:2.3.1.41] +synonym: "beta-ketoacyl-acyl-carrier-protein synthase II activity" NARROW [] +synonym: "beta-ketoacylsynthase activity" RELATED [EC:2.3.1.41] +synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] +synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] +synonym: "KAS I activity" NARROW [EC:2.3.1.41] +synonym: "KAS II" NARROW [EC:2.3.1.179] +synonym: "KASI" NARROW [EC:2.3.1.41] +synonym: "KASII" NARROW [EC:2.3.1.179] +synonym: "ketoacyl-ACP synthase activity" EXACT [] +xref: EC:2.3.1.41 +xref: MetaCyc:2.3.1.179-RXN +xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN +xref: RHEA:22836 +is_a: GO:0004312 ! fatty acid synthase activity + +[Term] +id: GO:0004316 +name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [RHEA:17397] +synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.100] +synonym: "3-ketoacyl acyl carrier protein reductase activity" RELATED [EC:1.1.1.100] +synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] +synonym: "3-oxoacyl-ACP reductase activity" EXACT [] +synonym: "3-oxoacyl-ACPreductase activity" RELATED [EC:1.1.1.100] +synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl thioester reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl-ACP reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl-acyl carrier protein reductase activity" RELATED [EC:1.1.1.100] +synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" RELATED [EC:1.1.1.100] +synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" RELATED [EC:1.1.1.100] +xref: EC:1.1.1.100 +xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN +xref: Reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP" +xref: RHEA:17397 +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004317 +name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [PMID:8088535, RHEA:41908] +synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" RELATED [EC:4.2.1.59] +synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [] +synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [] +synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [] +synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxypalmityl-ACP dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" RELATED [EC:4.2.1.59] +xref: EC:4.2.1.59 +xref: KEGG_REACTION:R04462 +xref: MetaCyc:4.2.1.61-RXN +xref: RHEA:41908 +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0004318 +name: enoyl-[acyl-carrier-protein] reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] +synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" RELATED [EC:1.3.1.9] +synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" RELATED [EC:1.3.1.9] +synonym: "enoyl-ACP reductase (NADH) activity" RELATED [EC:1.3.1.9] +synonym: "enoyl-acyl-carrier-protein reductase (NADH)" RELATED [EC:1.3.1.9] +synonym: "NADH-enoyl acyl carrier protein reductase activity" RELATED [EC:1.3.1.9] +synonym: "NADH-specific enoyl-ACP reductase activity" RELATED [EC:1.3.1.9] +xref: EC:1.3.1.9 +xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004319 +name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] +synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" RELATED [EC:1.3.1.10] +synonym: "enoyl acyl-carrier-protein reductase activity" RELATED [EC:1.3.1.10] +synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] +synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" RELATED [EC:1.3.1.10] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" RELATED [EC:1.3.1.10] +synonym: "NADPH 2-enoyl Co A reductase activity" RELATED [EC:1.3.1.10] +synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.10] +xref: EC:1.3.1.10 +xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004320 +name: oleoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "oleoyl-ACP hydrolase activity" EXACT [] +synonym: "oleoyl-ACP thioesterase activity" RELATED [EC:3.1.2.14] +synonym: "oleoyl-acyl carrier protein thioesterase activity" RELATED [EC:3.1.2.14] +synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] +xref: EC:3.1.2.14 +xref: MetaCyc:3.1.2.14-RXN +xref: MetaCyc:PWY-5142 +xref: RHEA:15057 +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0004321 +name: fatty-acyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" RELATED [EC:2.3.1.86] +synonym: "fatty acyl CoA synthase activity" EXACT [] +synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] +xref: EC:2.3.1.86 +xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN +xref: RHEA:22896 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0004322 +name: ferroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [RHEA:11148] +synonym: "caeruloplasmin" NARROW [] +synonym: "ceruloplasmin" NARROW [EC:1.16.3.1] +synonym: "Fe(II):oxygen oxidoreductase activity" RELATED [] +synonym: "ferro:O2 oxidoreductase activity" RELATED [] +synonym: "ferroxidase I" RELATED [] +synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" RELATED [] +synonym: "HEPH" NARROW [EC:1.16.3.1] +synonym: "hephaestin" NARROW [EC:1.16.3.1] +synonym: "iron(II): oxygen oxidoreductase activity" RELATED [] +synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] +xref: EC:1.16.3.1 +xref: MetaCyc:RXN0-1483 +xref: Reactome:R-HSA-1562603 "BfrB stores iron" +xref: Reactome:R-HSA-1562604 "BfrA stores iron" +xref: Reactome:R-HSA-1562626 "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)" +xref: Reactome:R-HSA-5621402 "Defective CP does not oxidise Fe2+ to Fe3+" +xref: Reactome:R-HSA-5691107 "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)" +xref: Reactome:R-HSA-917891 "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+" +xref: Reactome:R-HSA-917933 "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+" +xref: RHEA:11148 +is_a: GO:0016724 ! oxidoreductase activity, acting on metal ions, oxygen as acceptor + +[Term] +id: GO:0004323 +name: obsolete multicopper ferroxidase iron transport mediator activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "multicopper ferroxidase iron transport mediator activity" EXACT [] +is_obsolete: true +consider: GO:0004322 +consider: GO:0005381 + +[Term] +id: GO:0004324 +name: ferredoxin-NADP+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [GOC:kd, RHEA:20125] +comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. +synonym: "ferredoxin-NADP oxidoreductase activity" RELATED [EC:1.18.1.2] +synonym: "ferredoxin-NADP reductase activity" EXACT [] +synonym: "ferredoxin-NADP-oxidoreductase activity" RELATED [EC:1.18.1.2] +synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.2] +synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" RELATED [EC:1.18.1.2] +synonym: "ferredoxin-TPN reductase activity" RELATED [EC:1.18.1.2] +synonym: "ferredoxin:NADP+ oxidoreductase activity" RELATED [EC:1.18.1.2] +synonym: "NADP:ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.2] +synonym: "NADPH:ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.2] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" RELATED [EC:1.18.1.2] +synonym: "TPNH-ferredoxin reductase activity" RELATED [EC:1.18.1.2] +xref: EC:1.18.1.2 +xref: MetaCyc:1.18.1.2-RXN +xref: RHEA:20125 +is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity + +[Term] +id: GO:0004325 +name: ferrochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX." [RHEA:22584] +synonym: "ferro-protoporphyrin chelatase activity" RELATED [EC:4.99.1.1] +synonym: "heme synthase activity" RELATED [EC:4.99.1.1] +synonym: "heme synthetase activity" RELATED [EC:4.99.1.1] +synonym: "iron chelatase activity" RELATED [EC:4.99.1.1] +synonym: "protoheme ferro-lyase (protoporphyrin-forming)" RELATED [EC:4.99.1.1] +synonym: "protoheme ferro-lyase activity" RELATED [EC:4.99.1.1] +synonym: "protoheme ferrolyase activity" RELATED [EC:4.99.1.1] +xref: EC:4.99.1.1 +xref: KEGG_REACTION:R00310 +xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN +xref: Reactome:R-HSA-189465 "FECH binds Fe2+ to PRIN9 to form heme" +xref: RHEA:22584 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0004326 +name: tetrahydrofolylpolyglutamate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] +synonym: "folate polyglutamate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "folylpoly(gamma-glutamate) synthase activity" RELATED [EC:6.3.2.17] +synonym: "folylpoly-gamma-glutamate synthase activity" RELATED [EC:6.3.2.17] +synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "folylpolyglutamate synthase activity" EXACT [] +synonym: "folylpolyglutamate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "folylpolyglutamyl synthetase activity" RELATED [EC:6.3.2.17] +synonym: "formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "FPGS activity" RELATED [EC:6.3.2.17] +synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" RELATED [EC:6.3.2.17] +synonym: "tetrahydrofolate synthase activity" RELATED [EC:6.3.2.17] +synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" RELATED [EC:6.3.2.17] +synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.17] +synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.17] +xref: EC:6.3.2.17 +xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN +xref: Reactome:R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate" +xref: Reactome:R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate" +xref: Reactome:R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate" +xref: RHEA:10580 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004327 +name: obsolete formaldehyde dehydrogenase (glutathione) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] +comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. +synonym: "formaldehyde dehydrogenase (glutathione) activity" EXACT [] +is_obsolete: true +consider: GO:0051903 +consider: GO:0051907 + +[Term] +id: GO:0004328 +name: formamidase activity +namespace: molecular_function +alt_id: GO:0034566 +def: "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21948] +synonym: "formamide amidohydrolase activity" RELATED [EC:3.5.1.49] +synonym: "formamide hydrolase activity" EXACT [] +xref: EC:3.5.1.49 +xref: KEGG_REACTION:R00524 +xref: MetaCyc:FORMAMIDASE-RXN +xref: RHEA:21948 +xref: UM-BBD_reactionID:r0873 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004329 +name: formate-tetrahydrofolate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] +synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw] +synonym: "10-formyltetrahydrofolate synthetase activity" RELATED [EC:6.3.4.3] +synonym: "formate:tetrahydrofolate ligase (ADP-forming)" RELATED [EC:6.3.4.3] +synonym: "formyltetrahydrofolate synthetase activity" RELATED [EC:6.3.4.3] +synonym: "tetrahydrofolate formylase activity" RELATED [EC:6.3.4.3] +synonym: "tetrahydrofolic formylase activity" RELATED [EC:6.3.4.3] +xref: EC:6.3.4.3 +xref: MetaCyc:FORMATETHFLIG-RXN +xref: Reactome:R-HSA-200711 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate" +xref: Reactome:R-HSA-5696839 "MTHFD1L ligates HCOOH to THF to form 10-formyl-THF" +xref: Reactome:R-HSA-6801456 "MTHFD1L transforms 10-formyl-THF to HCOOH and THF" +xref: RHEA:20221 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004331 +name: fructose-2,6-bisphosphate 2-phosphatase activity +namespace: molecular_function +alt_id: GO:0004330 +def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46] +synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" RELATED [EC:3.1.3.46] +synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" RELATED [EC:3.1.3.46] +synonym: "fructose-2,6-bisphosphatase activity" RELATED [EC:3.1.3.46] +xref: EC:3.1.3.46 +xref: MetaCyc:3.1.3.46-RXN +xref: Reactome:R-HSA-5628905 "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate" +xref: Reactome:R-HSA-70262 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate" +xref: RHEA:17289 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0004332 +name: fructose-bisphosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13] +synonym: "1,6-diphosphofructose aldolase activity" RELATED [EC:4.1.2.13] +synonym: "aldolase activity" BROAD [EC:4.1.2.13] +synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.13] +synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.13] +synonym: "diphosphofructose aldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructoaldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructose 1,6-diphosphate aldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructose 1-monophosphate aldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructose 1-phosphate aldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructose diphosphate aldolase activity" RELATED [EC:4.1.2.13] +synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" RELATED [EC:4.1.2.13] +synonym: "ketose 1-phosphate aldolase activity" RELATED [EC:4.1.2.13] +synonym: "phosphofructoaldolase activity" RELATED [EC:4.1.2.13] +synonym: "SMALDO" RELATED [EC:4.1.2.13] +synonym: "zymohexase activity" RELATED [EC:4.1.2.13] +xref: EC:4.1.2.13 +xref: MetaCyc:F16ALDOLASE-RXN +xref: Reactome:R-HSA-71495 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate" +xref: Reactome:R-HSA-71496 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate" +xref: RHEA:14729 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004333 +name: fumarate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12460] +synonym: "(S)-malate hydro-lyase (fumarate-forming)" RELATED [EC:4.2.1.2] +synonym: "(S)-malate hydro-lyase activity" RELATED [EC:4.2.1.2] +synonym: "fumarase activity" RELATED [EC:4.2.1.2] +synonym: "L-malate hydro-lyase activity" RELATED [EC:4.2.1.2] +xref: EC:4.2.1.2 +xref: KEGG_REACTION:R01082 +xref: MetaCyc:FUMHYDR-RXN +xref: Reactome:R-HSA-451033 "(S)-Malate <=> Fumarate + H2O" +xref: Reactome:R-HSA-70982 "Fumarate + H2O <=> (S)-Malate" +xref: RHEA:12460 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004334 +name: fumarylacetoacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10244] +synonym: "4-fumarylacetoacetate fumarylhydrolase activity" RELATED [EC:3.7.1.2] +synonym: "beta-diketonase activity" RELATED [EC:3.7.1.2] +synonym: "fumarylacetoacetate hydrolase activity" RELATED [EC:3.7.1.2] +xref: EC:3.7.1.2 +xref: KEGG_REACTION:R01364 +xref: MetaCyc:FUMARYLACETOACETASE-RXN +xref: Reactome:R-HSA-71181 "fumarylacetoacetate => fumarate + acetoacetate" +xref: RHEA:10244 +xref: UM-BBD_reactionID:r0107 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0004335 +name: galactokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13553] +synonym: "ATP:D-galactose 1-phosphotransferase activity" RELATED [EC:2.7.1.6] +synonym: "ATP:D-galactose-1-phosphotransferase activity" RELATED [EC:2.7.1.6] +synonym: "galactokinase (phosphorylating)" RELATED [EC:2.7.1.6] +xref: EC:2.7.1.6 +xref: KEGG_REACTION:R01092 +xref: MetaCyc:GALACTOKIN-RXN +xref: Reactome:R-HSA-5610026 "Defective GALK1 does not phosphorylate Gal" +xref: Reactome:R-HSA-70355 "GALK1 phosphorylates Gal to Gal1P" +xref: RHEA:13553 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004336 +name: galactosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] +synonym: "beta-galactocerebrosidase activity" RELATED [EC:3.2.1.46] +synonym: "beta-galactosylceramidase activity" RELATED [EC:3.2.1.46] +synonym: "ceramide galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "cerebroside beta-galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "cerebroside galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" RELATED [EC:3.2.1.46] +synonym: "galactocerebrosidase activity" RELATED [EC:3.2.1.46] +synonym: "galactocerebroside beta-galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "galactocerebroside galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "galactocerebroside-beta-D-galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] +synonym: "galactosylceramide beta-galactosidase activity" RELATED [EC:3.2.1.46] +synonym: "galactosylcerebrosidase activity" RELATED [EC:3.2.1.46] +synonym: "galcerase activity" RELATED [EC:3.2.1.46] +synonym: "lactosylceramidase activity" RELATED [EC:3.2.1.46] +synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] +xref: EC:3.2.1.46 +xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN +xref: Reactome:R-HSA-1606564 "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide" +xref: RHEA:14297 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004337 +name: geranyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19361] +comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. +synonym: "farnesyl diphosphate synthetase activity" RELATED [EC:2.5.1.10] +synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] +synonym: "farnesyl-diphosphate synthase activity" EXACT [] +synonym: "farnesylpyrophosphate synthetase activity" RELATED [EC:2.5.1.10] +synonym: "FPP synthetase activity" RELATED [EC:2.5.1.10] +synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] +synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" RELATED [EC:2.5.1.10] +synonym: "geranyltransferase activity" RELATED [EC:2.5.1.10] +xref: EC:2.5.1.10 +xref: KEGG_REACTION:R02003 +xref: MetaCyc:FPPSYN-RXN +xref: Reactome:R-HSA-191303 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate" +xref: Reactome:R-HSA-8870469 "RGGT geranylgeranylates RAB proteins" +xref: RHEA:19361 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0004338 +name: glucan exo-1,3-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] +synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58] +synonym: "beta-1,3-glucan exo-hydrolase activity" RELATED [EC:3.2.1.58] +synonym: "exo (1->3)-beta-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "exo-1,3-beta-D-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "exo-1,3-beta-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "exo-1,3-beta-glucosidase activity" RELATED [EC:3.2.1.58] +synonym: "exo-beta-(1->3)-D-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "exo-beta-(1->3)-glucanohydrolase activity" RELATED [EC:3.2.1.58] +synonym: "exo-beta-1,3-D-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "exo-beta-1,3-glucanase activity" RELATED [EC:3.2.1.58] +synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah] +xref: EC:3.2.1.58 +xref: MetaCyc:3.2.1.58-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0004339 +name: glucan 1,4-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] +comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released. +synonym: "1,4-alpha-D-glucan glucohydrolase activity" RELATED [EC:3.2.1.3] +synonym: "amyloglucosidase activity" RELATED [EC:3.2.1.3] +synonym: "exo-1,4-alpha-glucosidase activity" RELATED [EC:3.2.1.3] +synonym: "gamma-1,4-glucan glucohydrolase activity" RELATED [EC:3.2.1.3] +synonym: "gamma-amylase activity" RELATED [EC:3.2.1.3] +synonym: "glucoamylase activity" EXACT [] +synonym: "glucose amylase activity" RELATED [EC:3.2.1.3] +synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] +xref: EC:3.2.1.3 +xref: MetaCyc:3.2.1.3-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004340 +name: glucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2] +synonym: "ATP:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.2] +synonym: "glucokinase (phosphorylating)" RELATED [EC:2.7.1.2] +synonym: "glucose kinase activity" RELATED [EC:2.7.1.2] +xref: EC:2.7.1.2 +xref: MetaCyc:GLUCOKIN-RXN +xref: Reactome:R-HSA-5621888 "Defective HK1 does not phosphorylate Glc to form G6P" +xref: Reactome:R-HSA-5621918 "Defective GCK does not phosphorylate Glc to form G6P" +xref: Reactome:R-HSA-70420 "HK1,2,3,GCK phosphorylate Glc to form G6P" +xref: RHEA:17825 +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0004341 +name: gluconolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] +synonym: "aldonolactonase activity" RELATED [EC:3.1.1.17] +synonym: "D-glucono-1,5-lactone lactonohydrolase activity" RELATED [EC:3.1.1.17] +synonym: "glucono-delta-lactonase activity" RELATED [EC:3.1.1.17] +synonym: "gulonolactonase activity" RELATED [EC:3.1.1.17] +synonym: "lactonase activity" BROAD [EC:3.1.1.17] +xref: EC:3.1.1.17 +xref: MetaCyc:GLUCONOLACT-RXN +xref: RHEA:10440 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004342 +name: glucosamine-6-phosphate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12172] +comment: Note that this function was formerly EC:5.3.1.10. +synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" RELATED [EC:3.5.99.6] +synonym: "aminodeoxyglucosephosphate isomerase activity" RELATED [EC:3.5.99.6] +synonym: "GlcN6P deaminase activity" RELATED [EC:3.5.99.6] +synonym: "glucosamine phosphate deaminase activity" RELATED [EC:3.5.99.6] +synonym: "glucosamine-6-phosphate isomerase activity" RELATED [EC:3.5.99.6] +synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] +synonym: "phosphoglucosamine isomerase activity" RELATED [EC:3.5.99.6] +synonym: "phosphoglucosaminisomerase activity" RELATED [EC:3.5.99.6] +xref: EC:3.5.99.6 +xref: KEGG_REACTION:R00765 +xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN +xref: Reactome:R-HSA-6799604 "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P" +xref: RHEA:12172 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0004343 +name: glucosamine 6-phosphate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10292] +synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.4] +synonym: "aminodeoxyglucosephosphate acetyltransferase activity" RELATED [EC:2.3.1.4] +synonym: "D-glucosamine-6-P N-acetyltransferase activity" RELATED [EC:2.3.1.4] +synonym: "glucosamine 6-phosphate acetylase activity" RELATED [EC:2.3.1.4] +synonym: "glucosamine-6-phosphate acetylase activity" RELATED [EC:2.3.1.4] +synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] +synonym: "N-acetylglucosamine-6-phosphate synthase activity" RELATED [EC:2.3.1.4] +synonym: "phosphoglucosamine acetylase activity" RELATED [EC:2.3.1.4] +synonym: "phosphoglucosamine N-acetylase activity" RELATED [EC:2.3.1.4] +synonym: "phosphoglucosamine transacetylase activity" RELATED [EC:2.3.1.4] +xref: EC:2.3.1.4 +xref: KEGG_REACTION:R02058 +xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN +xref: Reactome:R-HSA-449734 "Acetylation of glucosamine 6-phosphate to GlcNAc6P" +xref: RHEA:10292 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004344 +name: glucose dehydrogenase activity +namespace: molecular_function +alt_id: GO:0008708 +def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [PMID:22027299] +synonym: "D-glucose:(acceptor) 1-oxidoreductase" RELATED [EC:1.1.99.10] +synonym: "D-glucose:acceptor 1-oxidoreductase" RELATED [EC:1.1.5.2] +synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] +synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] +synonym: "glucose dehydrogenase (decarboxylating)" RELATED [EC:1.1.99.10] +xref: EC:1.1.99.10 +xref: KEGG_REACTION:R00305 +xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN +xref: RHEA:24540 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0004345 +name: glucose-6-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] +synonym: "6-phosphoglucose dehydrogenas" RELATED [] +synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] +synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] +synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.49] +synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] +synonym: "G6PD activity" RELATED [EC:1.1.1.49] +synonym: "G6PDH" EXACT [] +synonym: "GDH" RELATED [] +synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] +synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] +synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] +synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] +synonym: "Zwischenferment" RELATED [EC:1.1.1.49] +xref: EC:1.1.1.49 +xref: MetaCyc:GLU6PDEHYDROG-RXN +xref: Reactome:R-HSA-70377 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+" +xref: RHEA:15841 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004346 +name: glucose-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16689] +synonym: "D-glucose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.9] +synonym: "glucose 6-phosphate phosphatase activity" RELATED [EC:3.1.3.9] +xref: EC:3.1.3.9 +xref: KEGG_REACTION:R00303 +xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN +xref: Reactome:R-HSA-3262512 "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)" +xref: Reactome:R-HSA-3266566 "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)" +xref: Reactome:R-HSA-3274540 "Defective G6PC does not hydrolyze glucose 6-phosphate" +xref: Reactome:R-HSA-3282876 "Defective G6PC3 does not hydrolyze glucose 6-phosphate" +xref: Reactome:R-HSA-71825 "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)" +xref: RHEA:16689 +is_a: GO:0050309 ! sugar-terminal-phosphatase activity + +[Term] +id: GO:0004347 +name: glucose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] +synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.9] +synonym: "D-glucose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.9] +synonym: "glucose phosphate isomerase activity" RELATED [EC:5.3.1.9] +synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] +synonym: "hexose phosphate isomerase activity" RELATED [EC:5.3.1.9] +synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] +synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] +synonym: "phosphoglucoisomerase activity" RELATED [EC:5.3.1.9] +synonym: "phosphoglucose isomerase activity" RELATED [EC:5.3.1.9] +synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] +synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] +synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] +synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] +xref: EC:5.3.1.9 +xref: MetaCyc:PGLUCISOM-RXN +xref: Reactome:R-HSA-70471 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate" +xref: Reactome:R-HSA-70475 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate" +xref: RHEA:11816 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004348 +name: glucosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] +synonym: "acid beta-glucosidase activity" RELATED [EC:3.2.1.45] +synonym: "beta-D-glucocerebrosidase activity" RELATED [EC:3.2.1.45] +synonym: "beta-glucocerebrosidase activity" RELATED [EC:3.2.1.45] +synonym: "beta-glucosylceramidase activity" RELATED [EC:3.2.1.45] +synonym: "ceramide glucosidase activity" RELATED [EC:3.2.1.45] +synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" RELATED [EC:3.2.1.45] +synonym: "GlcCer-beta-glucosidase activity" RELATED [EC:3.2.1.45] +synonym: "glucocerebrosidase activity" RELATED [EC:3.2.1.45] +synonym: "glucosphingosine glucosylhydrolase activity" RELATED [EC:3.2.1.45] +synonym: "glucosylcerebrosidase activity" RELATED [EC:3.2.1.45] +synonym: "glucosylsphingosine beta-D-glucosidase activity" RELATED [EC:3.2.1.45] +synonym: "glucosylsphingosine beta-glucosidase activity" RELATED [EC:3.2.1.45] +synonym: "psychosine hydrolase activity" RELATED [EC:3.2.1.45] +xref: EC:3.2.1.45 +xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN +xref: Reactome:R-HSA-1605591 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide" +xref: Reactome:R-HSA-1861788 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)" +xref: Reactome:R-HSA-1861789 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)" +xref: RHEA:13269 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004349 +name: glutamate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14877] +synonym: "ATP-L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.11] +synonym: "ATP:gamma-L-glutamate phosphotransferase activity" RELATED [EC:2.7.2.11] +synonym: "ATP:L-glutamate 5-phosphotransferase activity" RELATED [EC:2.7.2.11] +synonym: "gamma-glutamate kinase activity" RELATED [EC:2.7.2.11] +synonym: "gamma-glutamyl kinase activity" RELATED [EC:2.7.2.11] +synonym: "glutamate kinase activity" RELATED [EC:2.7.2.11] +xref: EC:2.7.2.11 +xref: KEGG_REACTION:R00239 +xref: MetaCyc:GLUTKIN-RXN +xref: RHEA:14877 +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004350 +name: glutamate-5-semialdehyde dehydrogenase activity +namespace: molecular_function +alt_id: GO:0001513 +def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19541] +synonym: "beta-glutamylphosphate reductase activity" RELATED [EC:1.2.1.41] +synonym: "gamma-glutamyl phosphate reductase activity" RELATED [EC:1.2.1.41] +synonym: "gamma-glutamylphosphate reductase activity" RELATED [EC:1.2.1.41] +synonym: "glutamate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41] +synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41] +synonym: "glutamate-phosphate reductase activity" EXACT [] +synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.41] +synonym: "glutamylphosphate reductase activity" EXACT [] +synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.41] +xref: EC:1.2.1.41 +xref: KEGG_REACTION:R03313 +xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN +xref: RHEA:19541 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004351 +name: glutamate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] +synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] +synonym: "cysteic acid decarboxylase activity" RELATED [EC:4.1.1.15] +synonym: "gamma-glutamate decarboxylase activity" RELATED [EC:4.1.1.15] +synonym: "L-aspartate-alpha-decarboxylase activity" RELATED [EC:4.1.1.15] +synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" RELATED [EC:4.1.1.15] +synonym: "L-glutamate 1-carboxy-lyase activity" RELATED [EC:4.1.1.15] +synonym: "L-glutamate alpha-decarboxylase activity" RELATED [EC:4.1.1.15] +synonym: "L-glutamic acid decarboxylase activity" RELATED [EC:4.1.1.15] +synonym: "L-glutamic decarboxylase activity" RELATED [EC:4.1.1.15] +xref: EC:4.1.1.15 +xref: MetaCyc:GLUTDECARBOX-RXN +xref: Reactome:R-HSA-888572 "PXLP-K405-GAD1 decarboxylates L-Glu to form GABA" +xref: Reactome:R-HSA-888577 "Synthesis of GABA by GAD2" +xref: RHEA:17785 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004352 +name: glutamate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] +synonym: "glutamate dehydrogenase (NAD)" RELATED [EC:1.4.1.2] +synonym: "glutamate oxidoreductase activity" RELATED [EC:1.4.1.2] +synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] +synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] +synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.2] +synonym: "NAD-dependent glutamate dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-dependent glutamic dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-glutamate dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-linked glutamate dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-linked glutamic dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-specific glutamate dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD-specific glutamic dehydrogenase activity" RELATED [EC:1.4.1.2] +synonym: "NAD:glutamate oxidoreductase activity" RELATED [EC:1.4.1.2] +synonym: "NADH-linked glutamate dehydrogenase activity" RELATED [EC:1.4.1.2] +xref: EC:1.4.1.2 +xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN +xref: RHEA:15133 +is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004353 +name: glutamate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] +synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] +synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.3] +xref: EC:1.4.1.3 +xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN +xref: MetaCyc:GLUTAMATE-SYN2-PWY +xref: Reactome:R-HSA-70589 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]" +xref: Reactome:R-HSA-70600 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]" +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004354 +name: glutamate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" RELATED [EC:1.4.1.4] +synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] +synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] +synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] +synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.4] +synonym: "L-glutamic acid dehydrogenase activity" RELATED [EC:1.4.1.4] +synonym: "NAD(P)-glutamate dehydrogenase activity" RELATED [EC:1.4.1.4] +synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" RELATED [EC:1.4.1.4] +xref: EC:1.4.1.4 +xref: MetaCyc:GLUTDEHYD-RXN +xref: MetaCyc:GLUTSYNIII-PWY +xref: RHEA:11612 +is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004355 +name: glutamate synthase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15501] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" RELATED [EC:1.4.1.13] +synonym: "glutamate synthetase (NADP) activity" RELATED [EC:1.4.1.13] +synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" RELATED [EC:1.4.1.13] +synonym: "glutamine-ketoglutaric aminotransferase activity" RELATED [EC:1.4.1.13] +synonym: "GOGAT activity" BROAD [EC:1.4.1.13] +synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] +synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] +synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" RELATED [EC:1.4.1.13] +synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" RELATED [EC:1.4.1.13] +synonym: "NADPH GOGAT" EXACT [] +synonym: "NADPH-dependent glutamate synthase activity" RELATED [EC:1.4.1.13] +synonym: "NADPH-glutamate synthase activity" RELATED [EC:1.4.1.13] +synonym: "NADPH-linked glutamate synthase" RELATED [EC:1.4.1.13] +xref: EC:1.4.1.13 +xref: KEGG_REACTION:R00114 +xref: MetaCyc:GLUGLNSYN-PWY +xref: MetaCyc:GLUTAMATESYN-RXN +xref: MetaCyc:GLUTSYN-PWY +xref: RHEA:15501 +is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor + +[Term] +id: GO:0004356 +name: glutamate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16169] +synonym: "glutamine synthetase activity" EXACT [] +synonym: "glutamylhydroxamic synthetase activity" RELATED [EC:6.3.1.2] +synonym: "L-glutamate:ammonia ligase (ADP-forming)" RELATED [EC:6.3.1.2] +synonym: "L-glutamine synthetase activity" RELATED [EC:6.3.1.2] +xref: EC:6.3.1.2 +xref: KEGG_REACTION:R00253 +xref: MetaCyc:GLUTAMINESYN-RXN +xref: Reactome:R-HSA-70606 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]" +xref: RHEA:16169 +is_a: GO:0016211 ! ammonia ligase activity + +[Term] +id: GO:0004357 +name: glutamate-cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13285] +synonym: "gamma-glutamyl-L-cysteine synthetase activity" RELATED [EC:6.3.2.2] +synonym: "gamma-glutamylcysteine synthetase activity" RELATED [EC:6.3.2.2] +synonym: "gamma-glutamylcysteinyl synthetase activity" RELATED [EC:6.3.2.2] +synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" RELATED [EC:6.3.2.2] +xref: EC:6.3.2.2 +xref: KEGG_REACTION:R00894 +xref: MetaCyc:GLUTCYSLIG-RXN +xref: Reactome:R-HSA-174367 "GCL ligates L-Glu to L-Cys" +xref: Reactome:R-HSA-5602892 "Defective GCLC does not ligate L-Glu to L-Cys" +xref: RHEA:13285 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004358 +name: glutamate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15349] +synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "acetylglutamate synthetase activity" RELATED [EC:2.3.1.35] +synonym: "acetylglutamate-acetylornithine transacetylase activity" RELATED [EC:2.3.1.35] +synonym: "acetylglutamic synthetase activity" RELATED [EC:2.3.1.35] +synonym: "acetylglutamic-acetylornithine transacetylase activity" RELATED [EC:2.3.1.35] +synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] +synonym: "acetylornithine glutamate acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "glutamate acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] +synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] +synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] +synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "ornithine acetyltransferase activity" RELATED [EC:2.3.1.35] +synonym: "ornithine transacetylase activity" RELATED [EC:2.3.1.35] +xref: EC:2.3.1.35 +xref: KEGG_REACTION:R02282 +xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:15349 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004359 +name: glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] +synonym: "glutaminase I" RELATED [EC:3.5.1.2] +synonym: "glutamine aminohydrolase activity" RELATED [EC:3.5.1.2] +synonym: "L-glutaminase activity" RELATED [EC:3.5.1.2] +synonym: "L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.2] +xref: EC:3.5.1.2 +xref: MetaCyc:GLUTAMIN-RXN +xref: Reactome:R-HSA-70609 "glutamine + H2O => glutamate + NH4+ [GLS]" +xref: RHEA:15889 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004360 +name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13237] +synonym: "D-fructose-6-phosphate amidotransferase activity" RELATED [EC:2.6.1.16] +synonym: "GlcN6P synthase activity" RELATED [EC:2.6.1.16] +synonym: "glucosamine 6-phosphate synthase activity" RELATED [EC:2.6.1.16] +synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" RELATED [EC:2.6.1.16] +synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] +synonym: "glucosamine-6-phosphate synthase activity" RELATED [EC:2.6.1.16] +synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] +synonym: "hexosephosphate aminotransferase activity" RELATED [EC:2.6.1.16] +synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" RELATED [EC:2.6.1.16] +synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" RELATED [EC:2.6.1.16] +xref: EC:2.6.1.16 +xref: KEGG_REACTION:R00768 +xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN +xref: Reactome:R-HSA-4085027 "Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P" +xref: Reactome:R-HSA-449715 "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P" +xref: RHEA:13237 +is_a: GO:0070548 ! L-glutamine aminotransferase activity + +[Term] +id: GO:0004361 +name: glutaryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.8.6] +synonym: "glutaryl coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.6] +synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" RELATED [EC:1.3.8.6] +synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" RELATED [EC:1.3.8.6] +xref: EC:1.3.8.6 +xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-71046 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2" +xref: RHEA:13389 +xref: UM-BBD_reactionID:r0198 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0004362 +name: glutathione-disulfide reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732] +comment: Note that this function was formerly EC:1.6.4.2. +synonym: "glutathione reductase activity" EXACT [] +synonym: "glutathione S-reductase activity" RELATED [EC:1.8.1.7] +synonym: "glutathione-disulfide reductase activity" EXACT [] +synonym: "glutathione-disulphide reductase activity" EXACT [] +synonym: "glutathione:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.7] +synonym: "GSH reductase activity" RELATED [EC:1.8.1.7] +synonym: "GSSG reductase activity" RELATED [EC:1.8.1.7] +synonym: "NADPH-glutathione reductase activity" RELATED [EC:1.8.1.7] +synonym: "NADPH-GSSG reductase activity" RELATED [EC:1.8.1.7] +synonym: "NADPH:oxidized-glutathione oxidoreductase activity" RELATED [EC:1.8.1.7] +synonym: "oxidized glutathione reduction" RELATED [] +xref: EC:1.8.1.7 +xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN +xref: Reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" +xref: Reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" +xref: RHEA:11740 +is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0047134 ! protein-disulfide reductase (NAD(P)) activity + +[Term] +id: GO:0004363 +name: glutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13557] +synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" RELATED [EC:6.3.2.3] +synonym: "glutathione synthetase activity" RELATED [EC:6.3.2.3] +synonym: "GSH synthetase activity" RELATED [EC:6.3.2.3] +xref: EC:6.3.2.3 +xref: KEGG_REACTION:R00497 +xref: MetaCyc:GLUTATHIONE-SYN-RXN +xref: Reactome:R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH" +xref: Reactome:R-HSA-5602901 "Defective GSS does not synthesize GSH" +xref: RHEA:13557 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004364 +name: glutathione transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] +synonym: "glutathione conjugation reaction" EXACT [] +synonym: "glutathione S-alkyl transferase activity" RELATED [EC:2.5.1.18] +synonym: "glutathione S-alkyltransferase activity" RELATED [EC:2.5.1.18] +synonym: "glutathione S-aralkyltransferase activity" RELATED [EC:2.5.1.18] +synonym: "glutathione S-aryltransferase activity" RELATED [EC:2.5.1.18] +synonym: "glutathione S-transferase activity" RELATED [EC:2.5.1.18] +synonym: "RX:glutathione R-transferase activity" RELATED [EC:2.5.1.18] +synonym: "S-(hydroxyalkyl)glutathione lyase activity" RELATED [EC:2.5.1.18] +xref: EC:2.5.1.18 +xref: MetaCyc:GSHTRAN-RXN +xref: Reactome:R-HSA-176054 "GST dimers conjugate GSH with cytosolic substrates" +xref: Reactome:R-HSA-176059 "GST trimers transfer GS from GSH to luminal substrates" +xref: Reactome:R-HSA-3301943 "GSTK1 dimer transfers GS from GSH to CDNB" +xref: Reactome:R-HSA-5423653 "MGST trimers transfer GS from GSH to AFXBO and AFNBO" +xref: Reactome:R-HSA-9026777 "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" +xref: Reactome:R-HSA-9026780 "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" +xref: Reactome:R-HSA-9026901 "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1" +xref: Reactome:R-HSA-9026911 "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1" +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004365 +name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] +synonym: "3-phosphoglyceraldehyde dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.12] +synonym: "dehydrogenase, glyceraldehyde phosphate" RELATED [EC:1.2.1.12] +synonym: "GAPDH activity" RELATED [EC:1.2.1.12] +synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" RELATED [EC:1.2.1.12] +synonym: "glyceraldehyde-3-P-dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "phosphoglyceraldehyde dehydrogenase activity" RELATED [EC:1.2.1.12] +synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] +xref: EC:1.2.1.12 +xref: MetaCyc:GAPOXNPHOSPHN-RXN +xref: Reactome:R-HSA-70449 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+" +xref: Reactome:R-HSA-70482 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+" +xref: RHEA:10300 +is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity + +[Term] +id: GO:0004366 +name: glycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] +synonym: "3-glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "alpha-glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "glycerol phosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "glycerol phosphate transacylase activity" RELATED [EC:2.3.1.15] +synonym: "glycerophosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "glycerophosphate transacylase activity" RELATED [EC:2.3.1.15] +synonym: "sn-glycerol 3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15] +synonym: "sn-glycerol-3-phosphate acyltransferase activity" RELATED [EC:2.3.1.15] +xref: EC:2.3.1.15 +xref: MetaCyc:RXN-1381 +xref: Reactome:R-HSA-1482695 "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)" +xref: Reactome:R-HSA-549112 "G3P is acylated to 1-acyl LPA by AGPAT6" +xref: Reactome:R-HSA-75886 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]" +xref: RHEA:15325 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004367 +name: glycerol-3-phosphate dehydrogenase [NAD+] activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, RHEA:11092] +synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.8] +synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.8] +synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "glycerol phosphate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.8] +synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.8] +synonym: "glycerophosphate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.8] +synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] +synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] +synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] +synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] +synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] +synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] +synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] +xref: EC:1.1.1.8 +xref: KEGG_REACTION:R00842 +xref: MetaCyc:1.1.1.8-RXN +xref: Reactome:R-HSA-75889 "DHAP is converted to G3P by GPD1/GPD1L" +xref: RHEA:11092 +is_a: GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004368 +name: glycerol-3-phosphate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3] +comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. +synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" RELATED [EC:1.1.5.3] +synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" RELATED [EC:1.1.5.3] +synonym: "glycerol-3-phosphate CoQ reductase" RELATED [EC:1.1.5.3] +synonym: "glycerophosphate dehydrogenase activity" RELATED [EC:1.1.5.3] +synonym: "L-glycerophosphate dehydrogenase activity" RELATED [EC:1.1.5.3] +synonym: "sn-glycerol-3-phosphate dehydrogenase activity" RELATED [EC:1.1.5.3] +synonym: "sn-glycerol-3-phosphate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.3] +xref: EC:1.1.5.3 +xref: MetaCyc:RXN-9927 +xref: MetaCyc:RXN0-5260 +xref: Reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)" +xref: RHEA:18977 +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0004369 +name: glycerol-3-phosphate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18369] +synonym: "alpha-glycerophosphate oxidase activity" RELATED [EC:1.1.3.21] +synonym: "glycerol phosphate oxidase activity" RELATED [EC:1.1.3.21] +synonym: "glycerol-1-phosphate oxidase activity" RELATED [EC:1.1.3.21] +synonym: "L-alpha-glycerol-3-phosphate oxidase activity" RELATED [EC:1.1.3.21] +synonym: "L-alpha-glycerophosphate oxidase activity" RELATED [EC:1.1.3.21] +synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" RELATED [EC:1.1.3.21] +xref: EC:1.1.3.21 +xref: KEGG_REACTION:R00846 +xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN +xref: RHEA:18369 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0004370 +name: glycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21644] +synonym: "ATP:glycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.30] +synonym: "ATP:glycerol-3-phosphotransferase activity" RELATED [EC:2.7.1.30] +synonym: "GK" RELATED [EC:2.7.1.30] +synonym: "glyceric kinase activity" RELATED [EC:2.7.1.30] +synonym: "glycerokinase activity" RELATED [EC:2.7.1.30] +synonym: "glycerol kinase (phosphorylating)" RELATED [EC:2.7.1.30] +xref: EC:2.7.1.30 +xref: KEGG_REACTION:R00847 +xref: MetaCyc:GLYCEROL-KIN-RXN +xref: Reactome:R-HSA-75887 "Conversion of Glycerol to Glycerol-3-phosphate" +xref: RHEA:21644 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004371 +name: glycerone kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15773] +synonym: "acetol kinase (phosphorylating)" RELATED [EC:2.7.1.29] +synonym: "acetol kinase activity" RELATED [EC:2.7.1.29] +synonym: "ATP:glycerone phosphotransferase activity" RELATED [EC:2.7.1.29] +synonym: "dihydroxyacetone kinase activity" RELATED [EC:2.7.1.29] +xref: EC:2.7.1.29 +xref: KEGG_REACTION:R01011 +xref: MetaCyc:GLYCERONE-KINASE-RXN +xref: RHEA:15773 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004372 +name: glycine hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [RHEA:15481] +synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1] +synonym: "allothreonine aldolase activity" RELATED [EC:2.1.2.1] +synonym: "L-serine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1] +synonym: "serine aldolase activity" RELATED [EC:2.1.2.1] +synonym: "serine hydroxymethylase activity" RELATED [EC:2.1.2.1] +synonym: "serine hydroxymethyltransferase activity" RELATED [EC:2.1.2.1] +synonym: "serine transhydroxymethylase activity" RELATED [EC:2.1.2.1] +xref: EC:2.1.2.1 +xref: MetaCyc:GLYOHMETRANS-RXN +xref: Reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine" +xref: Reactome:R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine" +xref: Reactome:R-HSA-5694137 "PXLP-K280-SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine" +xref: Reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly" +xref: RHEA:15481 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004373 +name: glycogen (starch) synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] +synonym: "glycogen (starch) synthetase activity" EXACT [] +synonym: "UDP-glucose-glycogen glucosyltransferase activity" RELATED [EC:2.4.1.11] +synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.11] +synonym: "UDP-glycogen synthase activity" RELATED [EC:2.4.1.11] +synonym: "UDPG-glycogen synthetase activity" RELATED [EC:2.4.1.11] +synonym: "UDPG-glycogen transglucosylase activity" RELATED [EC:2.4.1.11] +synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.11] +synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" RELATED [EC:2.4.1.11] +xref: EC:2.4.1.11 +xref: MetaCyc:2.4.1.11-RXN +xref: Reactome:R-HSA-3322001 "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" +xref: Reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2" +xref: Reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" +xref: Reactome:R-HSA-3828061 "Defective GYS1 does not transfer glucose to growing glycogen chains" +xref: Reactome:R-HSA-3858506 "Defective GYS2 does not transfer glucose to growing glycogen chains" +xref: RHEA:18549 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0004374 +name: obsolete glycine cleavage system +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] +comment: This term was made obsolete because it represents a process rather than a function. +synonym: "glycine cleavage system" EXACT [] +synonym: "glycine synthase" BROAD [] +is_obsolete: true +replaced_by: GO:0019464 + +[Term] +id: GO:0004375 +name: glycine dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] +synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] +synonym: "glycine decarboxylase activity" RELATED [EC:1.4.4.2] +synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] +synonym: "glycine-cleavage complex P-protein activity" RELATED [EC:1.4.4.2] +synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" RELATED [EC:1.4.4.2] +synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" RELATED [EC:1.4.4.2] +synonym: "P-protein" NARROW [EC:1.4.4.2] +synonym: "protein P1" NARROW [EC:1.4.4.2] +xref: EC:1.4.4.2 +xref: MetaCyc:GCVP-RXN +xref: Reactome:R-HSA-5693967 "PXLP-K754-GLDC dimer decarboxylates Gly" +xref: RHEA:24304 +is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor + +[Term] +id: GO:0004376 +name: glycolipid mannosyltransferase activity +namespace: molecular_function +alt_id: GO:0004580 +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] +synonym: "glycolipid mannosyl transferase activity" EXACT [] +xref: Reactome:R-HSA-162821 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" +xref: Reactome:R-HSA-162873 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004377 +name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] +synonym: "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity" RELATED [EC:2.4.1.131] +synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131] +synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.131] +synonym: "glycolipid 2-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.131] +synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131] +synonym: "oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.131] +xref: EC:2.4.1.131 +xref: MetaCyc:2.4.1.131-RXN +xref: RHEA:29523 +is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0004378 +name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] +synonym: "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity" EXACT systematic_synonym [EC:2.4.1.132] +synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] +synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.132] +synonym: "glycolipid 3-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.132] +synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" RELATED [EC:2.4.1.132] +synonym: "mannosyltransferase II activity" RELATED [EC:2.4.1.132] +xref: EC:2.4.1.132 +xref: MetaCyc:2.4.1.132-RXN +xref: RHEA:29515 +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0004379 +name: glycylpeptide N-tetradecanoyltransferase activity +namespace: molecular_function +alt_id: GO:0019106 +def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] +synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" RELATED [EC:2.3.1.97] +synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" RELATED [EC:2.3.1.97] +synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] +synonym: "N-myristoyltransferase activity" EXACT [] +synonym: "peptide N-myristoyltransferase activity" RELATED [EC:2.3.1.97] +synonym: "peptide N-tetradecanoyltransferase activity" RELATED [EC:2.3.1.97] +synonym: "protein N-myristoyltransferase activity" RELATED [EC:2.3.1.97] +synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" RELATED [EC:2.3.1.97] +xref: EC:2.3.1.97 +xref: MetaCyc:2.3.1.97-RXN +xref: Reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2" +xref: Reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1" +xref: RHEA:15521 +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0019107 ! myristoyltransferase activity + +[Term] +id: GO:0004380 +name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] +synonym: "A transferase activity" RELATED [EC:2.4.1.40] +synonym: "A-transferase activity" RELATED [EC:2.4.1.40] +synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "blood-group substance alpha-acetyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] +synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" RELATED [EC:2.4.1.40] +synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] +synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.40] +synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.40] +xref: EC:2.4.1.40 +xref: MetaCyc:2.4.1.40-RXN +xref: Reactome:R-HSA-9033959 "ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC" +xref: Reactome:R-HSA-9034042 "sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec" +xref: RHEA:19021 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0004381 +name: fucosylgalactoside 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] +synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "B transferase activity" RELATED [EC:2.4.1.37] +synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] +synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] +synonym: "histo-blood substance B-dependent galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] +synonym: "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.37] +xref: EC:2.4.1.37 +xref: MetaCyc:2.4.1.37-RXN +xref: Reactome:R-HSA-9033961 "ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC" +xref: Reactome:R-HSA-9034053 "sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen" +xref: RHEA:14349 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0004382 +name: guanosine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286, RHEA:22156] +synonym: "GDP phosphohydrolase activity" RELATED [EC:3.6.1.42] +synonym: "GDPase activity" RELATED [EC:3.6.1.42] +synonym: "guanosine 5'-diphosphatase activity" RELATED [EC:3.6.1.6] +synonym: "guanosine diphosphatase activity" EXACT [] +xref: EC:3.6.1.42 +xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN +xref: RHEA:22156 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0004383 +name: guanylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] +synonym: "GTP diphosphate-lyase (cyclizing) activity" RELATED [EC:4.6.1.2] +synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" RELATED [EC:4.6.1.2] +synonym: "guanyl cyclase activity" RELATED [EC:4.6.1.2] +synonym: "guanylyl cyclase activity" EXACT [] +synonym: "receptor guanylate cyclase activity" NARROW [] +xref: EC:4.6.1.2 +xref: MetaCyc:GUANYLCYC-RXN +xref: Reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP" +xref: Reactome:R-HSA-74885 "GUCYs converts GTP to cGMP" +xref: RHEA:13665 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004384 +name: obsolete membrane-associated guanylate kinase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] +comment: This term was made obsolete because it represents a gene product and not a function. +synonym: "MAGUK" EXACT [] +synonym: "membrane-associated guanylate kinase" EXACT [] +is_obsolete: true +consider: GO:0004385 +consider: GO:0005102 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0050839 + +[Term] +id: GO:0004385 +name: guanylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] +synonym: "5'-GMP kinase activity" RELATED [EC:2.7.4.8] +synonym: "ATP:(d)GMP phosphotransferase activity" RELATED [EC:2.7.4.8] +synonym: "ATP:GMP phosphotransferase activity" RELATED [EC:2.7.4.8] +synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] +synonym: "GMP kinase activity" RELATED [EC:2.7.4.8] +synonym: "guanosine monophosphate kinase activity" RELATED [EC:2.7.4.8] +synonym: "membrane-associated guanylate kinase" NARROW [] +xref: EC:2.7.4.8 +xref: MetaCyc:GUANYL-KIN-RXN +xref: Reactome:R-HSA-110133 "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)" +xref: Reactome:R-HSA-73788 "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)" +xref: RHEA:20780 +is_a: GO:0050145 ! nucleoside monophosphate kinase activity + +[Term] +id: GO:0004386 +name: helicase activity +namespace: molecular_function +alt_id: GO:0008026 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:jl] +comment: Note that most helicases catalyze processive duplex unwinding. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_pir +subset: goslim_yeast +synonym: "ATP-dependent helicase activity" EXACT [] +xref: Reactome:R-HSA-169461 "MCM8 mediated fork unwinding" +xref: Reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding" +xref: Reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction" +xref: Reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA" +is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0004392 +name: heme oxygenase (decyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:21764] +synonym: "haem oxidase activity" RELATED [EC:1.14.14.18] +synonym: "haem oxygenase (decyclizing) activity" EXACT [] +synonym: "haem oxygenase activity" RELATED [EC:1.14.14.18] +synonym: "heme oxidase activity" RELATED [EC:1.14.14.18] +synonym: "heme oxygenase activity" RELATED [EC:1.14.14.18] +synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" RELATED [EC:1.14.14.18] +synonym: "ORP33 proteins" RELATED [EC:1.14.14.18] +xref: EC:1.14.14.18 +xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN +xref: Reactome:R-HSA-189398 "HMOX1 dimer, HMOX2 cleave heme" +xref: RHEA:21764 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004394 +name: heparan sulfate 2-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] +synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] +synonym: "heparin 2-sulfotransferase activity" RELATED [] +synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] +xref: EC:2.8.2.- +xref: Reactome:R-HSA-2076508 "HS2ST1 sulfates IdoA at C2 in heparan sulfate" +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0004395 +name: hexaprenyldihydroxybenzoate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] +synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" RELATED [EC:2.1.1.114] +synonym: "DHHB methyltransferase activity" RELATED [EC:2.1.1.114] +synonym: "DHHB-Mt activity" RELATED [EC:2.1.1.114] +synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" RELATED [EC:2.1.1.114] +synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" RELATED [EC:2.1.1.114] +xref: EC:2.1.1.114 +xref: MetaCyc:2.1.1.114-RXN +xref: RHEA:14121 +is_a: GO:0010420 ! 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity + +[Term] +id: GO:0004396 +name: hexokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] +synonym: "ATP-dependent hexokinase activity" RELATED [EC:2.7.1.1] +synonym: "ATP:D-hexose 6-phosphotransferase activity" RELATED [EC:2.7.1.1] +synonym: "glucose ATP phosphotransferase activity" RELATED [EC:2.7.1.1] +synonym: "hexokinase (phosphorylating)" RELATED [EC:2.7.1.1] +synonym: "hexokinase D" RELATED [EC:2.7.1.1] +synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] +synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] +synonym: "hexokinase type IV glucokinase activity" RELATED [EC:2.7.1.1] +xref: EC:2.7.1.1 +xref: MetaCyc:HEXOKINASE-RXN +xref: RHEA:22740 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004397 +name: histidine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] +synonym: "histidase activity" RELATED [GOC:hjd] +synonym: "histidinase activity" RELATED [GOC:hjd] +synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] +synonym: "L-histidine ammonia-lyase (urocanate-forming)" RELATED [EC:4.3.1.3] +synonym: "L-histidine ammonia-lyase activity" RELATED [EC:4.3.1.3] +xref: EC:4.3.1.3 +xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN +xref: Reactome:R-HSA-70899 "histidine => urocanate + NH4+" +xref: RHEA:21232 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0004398 +name: histidine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] +synonym: "L-histidine carboxy-lyase (histamine-forming)" RELATED [EC:4.1.1.22] +synonym: "L-histidine carboxy-lyase activity" RELATED [EC:4.1.1.22] +synonym: "L-histidine decarboxylase activity" RELATED [EC:4.1.1.22] +xref: EC:4.1.1.22 +xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-977301 "Histidine is decarboxylated to histamine" +xref: RHEA:20840 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004399 +name: histidinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] +xref: EC:1.1.1.23 +xref: MetaCyc:HISTALDEHYD-RXN +xref: MetaCyc:HISTOLDEHYD-RXN +xref: RHEA:20641 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004400 +name: histidinol-phosphate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] +synonym: "glutamic-imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9] +synonym: "histidine:imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9] +synonym: "histidinol phosphate aminotransferase activity" RELATED [EC:2.6.1.9] +synonym: "histidinol-phosphate aminotransferase activity" EXACT [] +synonym: "IAP transaminase activity" RELATED [EC:2.6.1.9] +synonym: "imidazole acetol-phosphate transaminase activity" RELATED [EC:2.6.1.9] +synonym: "imidazoleacetol phosphate transaminase activity" RELATED [EC:2.6.1.9] +synonym: "imidazolylacetolphosphate aminotransferase activity" RELATED [EC:2.6.1.9] +synonym: "imidazolylacetolphosphate transaminase activity" RELATED [EC:2.6.1.9] +synonym: "L-histidinol phosphate aminotransferase activity" RELATED [EC:2.6.1.9] +synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.9] +xref: EC:2.6.1.9 +xref: MetaCyc:HISTAMINOTRANS-RXN +xref: RHEA:23744 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004401 +name: histidinol-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14465] +synonym: "histidinol phosphate phosphatase activity" RELATED [EC:3.1.3.15] +synonym: "histidinolphosphatase activity" RELATED [EC:3.1.3.15] +synonym: "histidinolphosphate phosphatase activity" RELATED [EC:3.1.3.15] +synonym: "HPpase activity" RELATED [EC:3.1.3.15] +synonym: "L-histidinol phosphate phosphatase activity" RELATED [EC:3.1.3.15] +synonym: "L-histidinol-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.15] +xref: EC:3.1.3.15 +xref: KEGG_REACTION:R03013 +xref: MetaCyc:HISTIDPHOS-RXN +xref: RHEA:14465 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0004402 +name: histone acetyltransferase activity +namespace: molecular_function +alt_id: GO:0004403 +alt_id: GO:0004404 +alt_id: GO:0004405 +alt_id: GO:0004406 +alt_id: GO:0043166 +alt_id: GO:0046971 +def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] +comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. +synonym: "acetyl-CoA:histone acetyltransferase activity" RELATED [EC:2.3.1.48] +synonym: "H2A/H2B histone acetyltransferase activity" NARROW [] +synonym: "H3/H4 histone acetyltransferase activity" NARROW [] +synonym: "H4/H2 histone acetyltransferase activity" NARROW [] +synonym: "H4/H2A acetyltransferase activity" NARROW [] +synonym: "histone acetokinase activity" RELATED [EC:2.3.1.48] +synonym: "histone acetylase activity" EXACT [] +synonym: "histone lysine acetyltransferase activity" EXACT [] +synonym: "histone transacetylase activity" RELATED [EC:2.3.1.48] +synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48] +xref: EC:2.3.1.48 +xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-3301237 "KAT2 complexes acetylate histone H3" +xref: Reactome:R-HSA-3301345 "Elongator complex acetylates replicative histone H3, H4" +xref: Reactome:R-HSA-3318413 "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3" +xref: Reactome:R-HSA-3318415 "ATF2 acetylates histone H2B, H4" +xref: Reactome:R-HSA-3318486 "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3" +xref: Reactome:R-HSA-3321805 "NSL acetylates histone H4" +xref: Reactome:R-HSA-3321883 "MSL acetylates histone H4" +xref: Reactome:R-HSA-3321975 "NuA4 complex acetylates histone H2A, HIST1H4" +xref: Reactome:R-HSA-3451147 "KAT5 HAT complex acetylates TCF4 gene at histone H4" +xref: Reactome:R-HSA-3662318 "Type B histone acetlytransferase complex acetylates histone H4" +xref: Reactome:R-HSA-3662335 "EP300 acetylates histone H2A, H2B, H3, H4" +xref: Reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4" +xref: Reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4" +xref: Reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4" +xref: Reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9" +xref: RHEA:21992 +is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity + +[Term] +id: GO:0004407 +name: histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [PMID:9893272, RHEA:58196] +xref: EC:3.5.1.98 +xref: MetaCyc:3.5.1.98-RXN +xref: Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin" +xref: Reactome:R-HSA-2545253 "Deacetylation of cohesin" +xref: Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones" +xref: Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone" +xref: Reactome:R-HSA-3782637 "HDAC8 deacetylates histones" +xref: Reactome:R-HSA-3782655 "HDAC10 deacetylates histone" +xref: Reactome:R-HSA-427514 "eNoSC deacetylates histone H3" +xref: Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3" +xref: Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53" +xref: RHEA:58196 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0004408 +name: holocytochrome-c synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] +synonym: "cytochrome c heme-lyase activity" RELATED [EC:4.4.1.17] +synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] +synonym: "holocytochrome c synthetase activity" RELATED [EC:4.4.1.17] +synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" RELATED [EC:4.4.1.17] +synonym: "holocytochrome-c apocytochrome-c-lyase activity" RELATED [EC:4.4.1.17] +xref: EC:4.4.1.17 +xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN +xref: RHEA:22648 +is_a: GO:0016846 ! carbon-sulfur lyase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004409 +name: homoaconitate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15485] +synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] +synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.36] +synonym: "cis-homoaconitase activity" RELATED [EC:4.2.1.36] +synonym: "HACN activity" RELATED [EC:4.2.1.36] +synonym: "homoaconitase activity" RELATED [EC:4.2.1.36] +synonym: "Lys4" RELATED [EC:4.2.1.36] +synonym: "LysF" RELATED [EC:4.2.1.36] +xref: EC:4.2.1.36 +xref: KEGG_REACTION:R04371 +xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN +xref: RHEA:15485 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004410 +name: homocitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12929] +comment: Note that this function was formerly EC:4.1.3.21. +synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" RELATED [EC:2.3.3.14] +synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" RELATED [EC:2.3.3.14] +synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" RELATED [EC:2.3.3.14] +synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" RELATED [EC:2.3.3.14] +synonym: "homocitrate synthetase activity" RELATED [EC:2.3.3.14] +xref: EC:2.3.3.14 +xref: KEGG_REACTION:R00271 +xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN +xref: RHEA:12929 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004411 +name: homogentisate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15449] +synonym: "homogentisate dioxygenase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisate oxidase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisate oxygenase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.5] +synonym: "homogentisic acid oxidase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisic acid oxygenase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisic oxygenase activity" RELATED [EC:1.13.11.5] +synonym: "homogentisicase activity" RELATED [EC:1.13.11.5] +xref: EC:1.13.11.5 +xref: KEGG_REACTION:R02519 +xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN +xref: Reactome:R-HSA-71164 "homogentisate + O2 => maleylacetoacetate" +xref: RHEA:15449 +xref: UM-BBD_reactionID:r0105 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004412 +name: homoserine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] +xref: EC:1.1.1.3 +xref: MetaCyc:HOMOSERDEHYDROG-RXN +xref: RHEA:15761 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004413 +name: homoserine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13985] +synonym: "ATP:L-homoserine O-phosphotransferase activity" RELATED [EC:2.7.1.39] +synonym: "homoserine kinase (phosphorylating)" RELATED [EC:2.7.1.39] +synonym: "HSK" RELATED [EC:2.7.1.39] +xref: EC:2.7.1.39 +xref: KEGG_REACTION:R01771 +xref: MetaCyc:HOMOSERKIN-RXN +xref: RHEA:13985 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0004414 +name: homoserine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13701] +synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" RELATED [EC:2.3.1.31] +synonym: "homoserine acetyltransferase activity" RELATED [EC:2.3.1.31] +synonym: "homoserine O-trans-acetylase activity" RELATED [EC:2.3.1.31] +synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] +synonym: "homoserine-O-transacetylase activity" RELATED [EC:2.3.1.31] +synonym: "L-homoserine O-acetyltransferase activity" RELATED [EC:2.3.1.31] +xref: EC:2.3.1.31 +xref: KEGG_REACTION:R01776 +xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN +xref: RHEA:13701 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0004415 +name: hyalurononglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] +synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] +synonym: "chondroitinase I activity" RELATED [EC:3.2.1.35] +synonym: "hyaluronate 4-glycanohydrolase activity" RELATED [EC:3.2.1.35] +synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] +synonym: "hyaluronoglucosaminidase activity" EXACT [] +synonym: "hyaluronoglucosidase activity" RELATED [EC:3.2.1.35] +xref: EC:3.2.1.35 +xref: MetaCyc:3.2.1.35-RXN +xref: Reactome:R-HSA-1793209 "HYAL1 hydrolyses Chondroitin chains" +xref: Reactome:R-HSA-2160874 "HYAL1 hydrolyses (HA)50" +xref: Reactome:R-HSA-2160892 "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments" +xref: Reactome:R-HSA-2318585 "Defective HYAL1 does not hydrolyse Chondroitin chains" +xref: Reactome:R-HSA-5693356 "CEMIP hydrolyses HA" +xref: Reactome:R-HSA-9036077 "Defective HYAL1 does not hydrolyse (HA)50" +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004416 +name: hydroxyacylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] +synonym: "acetoacetylglutathione hydrolase activity" RELATED [EC:3.1.2.6] +synonym: "glyoxalase II activity" RELATED [EC:3.1.2.6] +synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" RELATED [EC:3.1.2.6] +synonym: "S-2-hydroxylacylglutathione hydrolase activity" RELATED [EC:3.1.2.6] +xref: EC:3.1.2.6 +xref: MetaCyc:GLYOXII-RXN +xref: Reactome:R-HSA-6783221 "HAGH hydrolyses (R)-S-LGSH to GSH and LACT" +xref: RHEA:25245 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0004417 +name: hydroxyethylthiazole kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24212] +synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" RELATED [EC:2.7.1.50] +synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" RELATED [EC:2.7.1.50] +synonym: "hydroxyethylthiazole kinase (phosphorylating)" RELATED [EC:2.7.1.50] +xref: EC:2.7.1.50 +xref: KEGG_REACTION:R04448 +xref: MetaCyc:THIAZOLSYN3-RXN +xref: RHEA:24212 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004418 +name: hydroxymethylbilane synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13185] +comment: Note that this function was formerly EC:4.3.1.8. +synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" RELATED [EC:2.5.1.61] +synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61] +synonym: "HMB-synthase activity" RELATED [EC:2.5.1.61] +synonym: "porphobilinogen ammonia-lyase (polymerizing)" RELATED [EC:2.5.1.61] +synonym: "porphobilinogen deaminase activity" RELATED [EC:2.5.1.61] +synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61] +synonym: "pre-uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61] +synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] +synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] +synonym: "uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61] +synonym: "uroporphyrinogen synthetase activity" RELATED [EC:2.5.1.61] +xref: EC:2.5.1.61 +xref: KEGG_REACTION:R00084 +xref: MetaCyc:OHMETHYLBILANESYN-RXN +xref: Reactome:R-HSA-189406 "4 PBGs bind to form HMB" +xref: RHEA:13185 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004419 +name: hydroxymethylglutaryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24404] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.4] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" RELATED [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" RELATED [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.4] +synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" RELATED [EC:4.1.3.4] +synonym: "HMG-CoA lyase activity" RELATED [EC:4.1.3.4] +synonym: "hydroxymethylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.4] +synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] +xref: EC:4.1.3.4 +xref: KEGG_REACTION:R01360 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN +xref: Reactome:R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA" +xref: Reactome:R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA" +xref: RHEA:24404 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004420 +name: hydroxymethylglutaryl-CoA reductase (NADPH) activity +namespace: molecular_function +alt_id: GO:0042282 +def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [PMID:29224355, RHEA:15989] +synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] +synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] +synonym: "hydroxymethylglutaryl-CoA reductase activity" RELATED [] +xref: EC:1.1.1.34 +xref: KEGG_REACTION:R02082 +xref: MetaCyc:1.1.1.34-RXN +xref: Reactome:R-HSA-191352 "HMGCR dimer reduces bHMG-CoA to MVA" +xref: RHEA:15989 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004421 +name: hydroxymethylglutaryl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10188] +comment: Note that this function was formerly EC:4.1.3.5. +synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" RELATED [EC:2.3.3.10] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" RELATED [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" RELATED [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" RELATED [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" RELATED [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" RELATED [EC:2.3.3.10] +synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" RELATED [EC:2.3.3.10] +synonym: "acetoacetyl coenzyme A transacetase activity" RELATED [EC:2.3.3.10] +synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.10] +synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" RELATED [EC:2.3.3.10] +synonym: "HMG-CoA synthase activity" RELATED [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme A synthase activity" RELATED [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] +synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" RELATED [EC:2.3.3.10] +xref: EC:2.3.3.10 +xref: KEGG_REACTION:R01978 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN +xref: Reactome:R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA" +xref: Reactome:R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH" +xref: RHEA:10188 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004422 +name: hypoxanthine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] +synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] +synonym: "HGPRTase activity" RELATED [EC:2.4.2.8] +synonym: "HPRT" RELATED [EC:2.4.2.8] +synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] +synonym: "IMP diphosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "IMP pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "IMP-GMP pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "inosinate pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "inosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "inosinic acid pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "inosinic pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] +xref: EC:2.4.2.8 +xref: KEGG_REACTION:R01132 +xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN +xref: Reactome:R-HSA-74215 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)" +xref: RHEA:17973 +is_a: GO:0106130 ! purine phosphoribosyltransferase activity + +[Term] +id: GO:0004423 +name: iduronate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] +synonym: "2-sulfo-L-iduronate 2-sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] +synonym: "iduronate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "iduronate sulfate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "iduronate-2-sulfate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "iduronate-2-sulphatase activity" EXACT [] +synonym: "iduronide-2-sulfate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "idurono-2-sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "L-iduronate 2-sulfate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" RELATED [EC:3.1.6.13] +synonym: "L-idurono sulfate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "L-iduronosulfatase activity" RELATED [EC:3.1.6.13] +synonym: "sulfo-L-iduronate sulfatase activity" RELATED [EC:3.1.6.13] +synonym: "sulfoiduronate sulfohydrolase activity" RELATED [EC:3.1.6.13] +xref: EC:3.1.6.13 +xref: MetaCyc:3.1.6.13-RXN +xref: Reactome:R-HSA-1678650 "IDS hydrolyses Heparan sulfate chain(5)" +xref: Reactome:R-HSA-1793182 "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)" +xref: Reactome:R-HSA-2262743 "Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)" +xref: Reactome:R-HSA-9036046 "Defective IDS does not hydrolyse Heparan sulfate chain(5)" +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004424 +name: imidazoleglycerol-phosphate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11040] +synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] +synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" RELATED [EC:4.2.1.19] +synonym: "IGP dehydratase activity" RELATED [EC:4.2.1.19] +synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] +xref: EC:4.2.1.19 +xref: KEGG_REACTION:R03457 +xref: MetaCyc:IMIDPHOSDEHYD-RXN +xref: RHEA:11040 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004425 +name: indole-3-glycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] +synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" RELATED [EC:4.1.1.48] +synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] +synonym: "indole-3-glycerophosphate synthase activity" RELATED [EC:4.1.1.48] +synonym: "indoleglycerol phosphate synthase activity" RELATED [EC:4.1.1.48] +synonym: "indoleglycerol phosphate synthetase activity" RELATED [EC:4.1.1.48] +xref: EC:4.1.1.48 +xref: MetaCyc:IGPSYN-RXN +xref: RHEA:23476 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004427 +name: inorganic diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24576] +synonym: "diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.1] +synonym: "inorganic pyrophosphatase activity" RELATED [EC:3.6.1.1] +synonym: "pyrophosphate phosphohydrolase activity" RELATED [EC:3.6.1.1] +xref: EC:3.6.1.1 +xref: KEGG_REACTION:R00004 +xref: MetaCyc:INORGPYROPHOSPHAT-RXN +xref: Reactome:R-HSA-449937 "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]" +xref: Reactome:R-HSA-6788912 "LHPP:Mg2+ dimer hydrolyses PPi" +xref: Reactome:R-HSA-71732 "pyrophosphate + H2O => 2 orthophosphate [cytosolic]" +xref: RHEA:24576 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004428 +name: obsolete inositol or phosphatidylinositol kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] +comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. +synonym: "inositol or phosphatidylinositol kinase activity" EXACT [] +synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] +is_obsolete: true +consider: GO:0016307 +consider: GO:0019140 +consider: GO:0052742 +consider: GO:0052813 + +[Term] +id: GO:0004430 +name: 1-phosphatidylinositol 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19877] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" RELATED [EC:2.7.1.67] +synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] +synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI 4-kinase activity" RELATED [EC:2.7.1.67] +synonym: "PI kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "PI4K" BROAD [EC:2.7.1.67] +synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] +synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] +synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] +xref: EC:2.7.1.67 +xref: KEGG_REACTION:R03361 +xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN +xref: Reactome:R-HSA-1675780 "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane" +xref: Reactome:R-HSA-1675813 "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane" +xref: Reactome:R-HSA-1675883 "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane" +xref: Reactome:R-HSA-1675974 "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane" +xref: Reactome:R-HSA-1676185 "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane" +xref: RHEA:19877 +is_a: GO:0052742 ! phosphatidylinositol kinase activity + +[Term] +id: GO:0004432 +name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA +namespace: molecular_function +def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] +comment: This term was made obsolete because it is not a valid molecular function. +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" EXACT [] +is_obsolete: true +consider: GO:0016308 + +[Term] +id: GO:0004433 +name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB +namespace: molecular_function +def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] +comment: This term was made obsolete because it is not a valid molecular function. +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" EXACT [] +is_obsolete: true +consider: GO:0016308 + +[Term] +id: GO:0004435 +name: phosphatidylinositol phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:33179] +synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED [EC:3.1.4.11] +synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" RELATED [EC:3.1.4.11] +synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] +synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] +synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] +synonym: "phosphoinositidase C activity" RELATED [EC:3.1.4.11] +synonym: "phosphoinositide phospholipase C activity" RELATED [EC:3.1.4.11] +synonym: "PI-PLC activity" RELATED [EC:3.1.4.11] +synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] +xref: EC:3.1.4.11 +xref: KEGG_REACTION:R03435 +xref: MetaCyc:3.1.4.11-RXN +xref: Reactome:R-HSA-111879 "PIP2 hydrolysis" +xref: Reactome:R-HSA-167686 "Active PLCG1 hydrolyses PIP2" +xref: Reactome:R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane" +xref: Reactome:R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane" +xref: Reactome:R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane" +xref: Reactome:R-HSA-202407 "PLC-gamma1 hydrolyses PIP2" +xref: Reactome:R-HSA-2730847 "Hydrolysis of PIP2 by PLCG" +xref: Reactome:R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2" +xref: Reactome:R-HSA-622382 "PIP2 hydrolysis" +xref: Reactome:R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate" +xref: RHEA:33179 +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0004436 +name: phosphatidylinositol diacylglycerol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] +comment: Note that this function was formerly EC:3.1.4.10. +synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" RELATED [EC:4.6.1.13] +synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" RELATED [EC:4.6.1.13] +synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" RELATED [EC:4.6.1.13] +synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] +synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] +xref: EC:4.6.1.13 +xref: MetaCyc:3.1.4.10-RXN +xref: RHEA:17093 +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0004437 +name: obsolete inositol or phosphatidylinositol phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] +comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. +synonym: "inositol or phosphatidylinositol phosphatase activity" EXACT [] +synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] +is_obsolete: true +consider: GO:0034593 +consider: GO:0034594 +consider: GO:0052744 +consider: GO:0052745 + +[Term] +id: GO:0004438 +name: phosphatidylinositol-3-phosphatase activity +namespace: molecular_function +alt_id: GO:0016315 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] +comment: Note that this function includes EC:3.1.3.65. +synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64] +synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64] +synonym: "inositol 1,3-bisphosphate phosphatase activity" RELATED [EC:3.1.3.64] +synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" RELATED [EC:3.1.3.64] +synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] +synonym: "inositol-polyphosphate 3-phosphatase activity" RELATED [EC:3.1.3.64] +synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.64] +xref: EC:3.1.3.64 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN +xref: Reactome:R-HSA-1675795 "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane" +xref: Reactome:R-HSA-1675994 "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane" +xref: Reactome:R-HSA-1676114 "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane" +xref: Reactome:R-HSA-1676141 "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane" +xref: Reactome:R-HSA-6809325 "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane" +xref: Reactome:R-HSA-6809720 "PI3P is dephosphorylated to PI by MTM1:MTMR12" +xref: Reactome:R-HSA-6809777 "PI3P is dephosphorylated to PI by MTMR2:SBF1" +xref: Reactome:R-HSA-6809975 "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane" +xref: RHEA:12316 +is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity + +[Term] +id: GO:0004439 +name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +alt_id: GO:0001668 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22764] +synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" RELATED [EC:3.1.3.36] +synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] +synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] +synonym: "PI(4,5)P2 5-phosphatase activity" EXACT [GOC:mah, PMID:15249580] +synonym: "PtdIns(4,5)P(2) 5-phosphatase activity" RELATED [EC:3.1.3.36, GOC:mah] +synonym: "PtdIns(4,5)P2 5-phosphatase activity" RELATED [EC:3.1.3.36, GOC:mah] +synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] +synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] +xref: EC:3.1.3.36 +xref: KEGG_REACTION:R04404 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN +xref: Reactome:R-HSA-1675824 "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane" +xref: Reactome:R-HSA-1676177 "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane" +xref: Reactome:R-HSA-8868648 "SYNJ hydrolyze PI(4,5)P2 to PI(4)P" +xref: RHEA:22764 +is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity +is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity + +[Term] +id: GO:0004441 +name: inositol-1,4-bisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] +synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.57] +synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] +synonym: "inositol-polyphosphate 1-phosphatase activity" RELATED [EC:3.1.3.57] +xref: EC:3.1.3.57 +xref: MetaCyc:3.1.3.57-RXN +xref: Reactome:R-HSA-1855208 "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol" +xref: RHEA:15553 +is_a: GO:0016312 ! inositol bisphosphate phosphatase activity + +[Term] +id: GO:0004442 +name: obsolete inositol-1,4,-bisphosphate 3-phosphatase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] +synonym: "inositol-1,4,-bisphosphate 3-phosphatase" EXACT [] +is_obsolete: true +consider: GO:0004438 + +[Term] +id: GO:0004443 +name: obsolete inositol-1,4,-bisphosphate 4-phosphatase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] +synonym: "inositol-1,4,-bisphosphate 4-phosphatase" EXACT [] +is_obsolete: true +consider: GO:0016316 + +[Term] +id: GO:0004444 +name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase +namespace: molecular_function +def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] +comment: This term was made obsolete because the existence of this function has not been established. +synonym: "inositol-1,4,5-trisphosphate 1-phosphatase" EXACT [] +is_obsolete: true +consider: GO:0046030 + +[Term] +id: GO:0004445 +name: inositol-polyphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] +comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. +synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56] +synonym: "5PTase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] +synonym: "inositol polyphosphate-5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED [] +synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56] +synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] +synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] +synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] +synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] +synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] +xref: EC:3.1.3.56 +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0004446 +name: inositol-hexakisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] +synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.62] +synonym: "inositol tetrakisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.62] +synonym: "MIPP activity" BROAD [EC:3.1.3.62] +synonym: "multiple inositol-polyphosphate phosphatase activity" BROAD [EC:3.1.3.62] +xref: EC:3.1.3.62 +xref: MetaCyc:RXN-7920 +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0004447 +name: iodide peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [RHEA:23336] +synonym: "iodinase activity" RELATED [EC:1.11.1.8] +synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] +synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] +synonym: "TPO activity" RELATED [EC:1.11.1.8] +xref: EC:1.11.1.8 +xref: MetaCyc:IODIDE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004448 +name: isocitrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] +synonym: "beta-ketoglutaric-isocitric carboxylase activity" RELATED [EC:1.1.1.-] +synonym: "IDH activity" RELATED [EC:1.1.1.-] +synonym: "IDP activity" RELATED [EC:1.1.1.-] +synonym: "IDP1" RELATED [EC:1.1.1.-] +synonym: "IDP2" RELATED [EC:1.1.1.-] +synonym: "IDP3" RELATED [EC:1.1.1.-] +synonym: "isocitric acid dehydrogenase activity" RELATED [EC:1.1.1.-] +synonym: "isocitric dehydrogenase activity" RELATED [EC:1.1.1.-] +synonym: "oxalosuccinate carboxylase activity" RELATED [EC:1.1.1.-] +synonym: "oxalosuccinate decarboxylase activity" RELATED [EC:1.1.1.-] +synonym: "oxalsuccinic decarboxylase activity" RELATED [EC:1.1.1.-] +xref: MetaCyc:ISOCITDEH-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004449 +name: isocitrate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] +synonym: "isocitrate dehydrogenase (NAD) activity" RELATED [EC:1.1.1.41] +synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.41] +synonym: "NAD dependent isocitrate dehydrogenase activity" RELATED [EC:1.1.1.41] +synonym: "NAD isocitrate dehydrogenase activity" RELATED [EC:1.1.1.41] +synonym: "NAD isocitric dehydrogenase activity" RELATED [EC:1.1.1.41] +synonym: "NAD-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.41] +synonym: "NAD-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.41] +synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" RELATED [EC:1.1.1.41] +xref: EC:1.1.1.41 +xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN +xref: Reactome:R-HSA-70967 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]" +xref: RHEA:23632 +is_a: GO:0004448 ! isocitrate dehydrogenase activity + +[Term] +id: GO:0004450 +name: isocitrate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] +synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate (NADP) dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate dehydrogenase (NADP) activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate dehydrogenase (NADP-dependent) activity" RELATED [EC:1.1.1.42] +synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.42] +synonym: "NADP isocitric dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "NADP(+)-ICDH activity" RELATED [EC:1.1.1.42] +synonym: "NADP(+)-IDH activity" RELATED [EC:1.1.1.42] +synonym: "NADP(+)-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "NADP-dependent isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "NADP-dependent isocitric dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "NADP-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "NADP-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] +xref: EC:1.1.1.42 +xref: MetaCyc:ISOCITDEH-RXN +xref: Reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" +xref: Reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" +xref: Reactome:R-HSA-450984 "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]" +xref: RHEA:19629 +is_a: GO:0004448 ! isocitrate dehydrogenase activity + +[Term] +id: GO:0004451 +name: isocitrate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13245] +synonym: "ICL activity" RELATED [EC:4.1.3.1] +synonym: "isocitrase activity" RELATED [EC:4.1.3.1] +synonym: "isocitratase activity" RELATED [EC:4.1.3.1] +synonym: "isocitrate glyoxylate-lyase (succinate-forming)" RELATED [EC:4.1.3.1] +synonym: "isocitrate glyoxylate-lyase activity" RELATED [EC:4.1.3.1] +synonym: "isocitritase activity" RELATED [EC:4.1.3.1] +synonym: "threo-DS-isocitrate glyoxylate-lyase activity" RELATED [EC:4.1.3.1] +xref: EC:4.1.3.1 +xref: KEGG_REACTION:R00479 +xref: MetaCyc:ISOCIT-CLEAV-RXN +xref: RHEA:13245 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0004452 +name: isopentenyl-diphosphate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23284] +synonym: "IPP isomerase activity" RELATED [EC:5.3.3.2] +synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] +synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" RELATED [EC:5.3.3.2] +synonym: "isopentenylpyrophosphate delta-isomerase activity" RELATED [EC:5.3.3.2] +synonym: "isopentenylpyrophosphate isomerase activity" RELATED [EC:5.3.3.2] +synonym: "methylbutenylpyrophosphate isomerase activity" RELATED [EC:5.3.3.2] +xref: EC:5.3.3.2 +xref: KEGG_REACTION:R01123 +xref: MetaCyc:IPPISOM-RXN +xref: Reactome:R-HSA-191382 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate" +xref: RHEA:23284 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004453 +name: juvenile-hormone esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [PMID:11267890, RHEA:16393] +subset: goslim_chembl +synonym: "JH esterase activity" RELATED [EC:3.1.1.59] +synonym: "JH-esterase activity" RELATED [EC:3.1.1.59] +synonym: "juvenile hormone analog esterase activity" RELATED [EC:3.1.1.59] +synonym: "juvenile hormone carboxyesterase activity" RELATED [EC:3.1.1.59] +synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" RELATED [EC:3.1.1.59] +xref: EC:3.1.1.59 +xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN +xref: RHEA:16393 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004454 +name: ketohexokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] +synonym: "ATP:D-fructose 1-phosphotransferase activity" RELATED [EC:2.7.1.3] +synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] +synonym: "ketohexokinase (phosphorylating)" RELATED [EC:2.7.1.3] +xref: EC:2.7.1.3 +xref: MetaCyc:KETOHEXOKINASE-RXN +xref: Reactome:R-HSA-5656459 "Defective KHK does not phosphorylate beta-D-fructose" +xref: Reactome:R-HSA-70333 "KHK dimer phosphorylates Fru to Fru 1-P" +xref: RHEA:18145 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004455 +name: ketol-acid reductoisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] +synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" RELATED [EC:1.1.1.86] +synonym: "2-hydroxy-3-keto acid reductoisomerase activity" RELATED [EC:1.1.1.86] +synonym: "acetohydroxy acid isomeroreductase activity" RELATED [EC:1.1.1.86] +synonym: "acetohydroxy acid reductoisomerase activity" RELATED [EC:1.1.1.86] +synonym: "acetolactate reductoisomerase activity" RELATED [EC:1.1.1.86] +synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" RELATED [EC:1.1.1.86] +synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" RELATED [EC:1.1.1.86] +synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" RELATED [EC:1.1.1.86] +synonym: "isomeroreductase activity" RELATED [EC:1.1.1.86] +synonym: "ketol acid reductoisomerase activity" RELATED [EC:1.1.1.86] +synonym: "reductoisomerase activity" RELATED [EC:1.1.1.86] +xref: EC:1.1.1.86 +xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN +xref: RHEA:22068 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004456 +name: phosphogluconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17277] +synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" RELATED [EC:4.2.1.12] +synonym: "6-phospho-D-gluconate hydro-lyase activity" RELATED [EC:4.2.1.12] +synonym: "6-phosphogluconate dehydrase activity" RELATED [EC:4.2.1.12] +synonym: "6-phosphogluconate dehydratase activity" RELATED [EC:4.2.1.12] +synonym: "6-phosphogluconic dehydrase activity" RELATED [EC:4.2.1.12] +synonym: "gluconate 6-phosphate dehydratase activity" RELATED [EC:4.2.1.12] +synonym: "gluconate-6-phosphate dehydratase activity" RELATED [EC:4.2.1.12] +xref: EC:4.2.1.12 +xref: KEGG_REACTION:R02036 +xref: MetaCyc:PGLUCONDEHYDRAT-RXN +xref: RHEA:17277 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004457 +name: lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0004458 +name: D-lactate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate." [RHEA:13521] +synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [] +synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" RELATED [] +synonym: "D-(-)-lactic cytochrome c reductase activity" RELATED [EC:1.1.2.4] +synonym: "D-lactate (cytochrome) dehydrogenase activity" RELATED [EC:1.1.2.4] +synonym: "D-lactate ferricytochrome c oxidoreductase activity" RELATED [EC:1.1.2.4] +synonym: "D-lactate-cytochrome c reductase activity" RELATED [] +synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] +xref: EC:1.1.2.4 +xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:13521 +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0004459 +name: L-lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444] +synonym: "L-lactic acid dehydrogenase activity" RELATED [EC:1.1.1.27] +synonym: "L-lactic dehydrogenase activity" RELATED [EC:1.1.1.27] +xref: EC:1.1.1.27 +xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT" +xref: Reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR" +xref: Reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT" +xref: RHEA:23444 +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004460 +name: L-lactate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate." [RHEA:19909] +synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" RELATED [EC:1.1.2.3] +synonym: "cytochrome b2" RELATED [] +synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] +synonym: "dehydrogenase, lactate (cytochrome)" RELATED [EC:1.1.2.3] +synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] +synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3] +synonym: "L-lactate cytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3] +synonym: "L-lactate cytochrome c reductase activity" RELATED [EC:1.1.2.3] +synonym: "L-lactate ferricytochrome c oxidoreductase activity" RELATED [EC:1.1.2.3] +synonym: "lactate dehydrogenase (cytochrome)" RELATED [EC:1.1.2.3] +synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] +synonym: "lactic cytochrome c reductase activity" RELATED [EC:1.1.2.3] +xref: EC:1.1.2.3 +xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:19909 +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0004461 +name: lactose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] +synonym: "lactose synthetase activity" RELATED [EC:2.4.1.22] +synonym: "UDP-galactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22] +synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" RELATED [EC:2.4.1.22] +synonym: "UDPgalactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22] +synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" RELATED [EC:2.4.1.22] +synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" RELATED [EC:2.4.1.22] +xref: EC:2.4.1.22 +xref: MetaCyc:LACTOSE-SYNTHASE-RXN +xref: Reactome:R-HSA-5653878 "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac" +xref: RHEA:12404 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0004462 +name: lactoylglutathione lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19069] +synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" RELATED [EC:4.4.1.5] +synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" RELATED [EC:4.4.1.5] +synonym: "aldoketomutase activity" RELATED [EC:4.4.1.5] +synonym: "glyoxalase I activity" RELATED [EC:4.4.1.5] +synonym: "glyoxylase I" RELATED [EC:4.4.1.5] +synonym: "ketone-aldehyde mutase activity" RELATED [EC:4.4.1.5] +synonym: "methylglyoxalase activity" RELATED [EC:4.4.1.5] +xref: EC:4.4.1.5 +xref: KEGG_REACTION:R02530 +xref: MetaCyc:GLYOXI-RXN +xref: Reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH" +xref: RHEA:19069 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004463 +name: leukotriene-A4 hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324] +synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" RELATED [EC:3.3.2.6] +synonym: "leukotriene A(4) hydrolase activity" RELATED [EC:3.3.2.6] +synonym: "leukotriene A4 hydrolase activity" RELATED [EC:3.3.2.6] +synonym: "LTA-4 hydrolase activity" RELATED [EC:3.3.2.6] +synonym: "LTA4 hydrolase activity" RELATED [EC:3.3.2.6] +synonym: "LTA4H" RELATED [EC:3.3.2.6] +xref: EC:3.3.2.6 +xref: KEGG_REACTION:R03057 +xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN +xref: Reactome:R-HSA-266072 "LTA4 is hydolysed to LTB4 by LTA4H" +xref: RHEA:22324 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0004464 +name: leukotriene-C4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17617] +comment: Note that this function was EC:2.5.1.37. +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" RELATED [EC:4.4.1.20] +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" RELATED [EC:4.4.1.20] +synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" RELATED [EC:4.4.1.20] +synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" RELATED [EC:4.4.1.20] +synonym: "leukotriene C(4) synthetase activity" RELATED [EC:4.4.1.20] +synonym: "leukotriene C4 synthetase activity" RELATED [EC:4.4.1.20] +synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" RELATED [EC:4.4.1.20] +synonym: "LTC(4) synthase activity" RELATED [EC:4.4.1.20] +synonym: "LTC(4) synthetase activity" RELATED [EC:4.4.1.20] +synonym: "LTC4 synthase activity" RELATED [EC:4.4.1.20] +synonym: "LTC4 synthetase activity" RELATED [EC:4.4.1.20] +xref: EC:4.4.1.20 +xref: KEGG_REACTION:R03059 +xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN +xref: Reactome:R-HSA-266050 "LTA4 is converted to LTC4 by LTC4S" +xref: RHEA:17617 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0004465 +name: lipoprotein lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf] +synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] +synonym: "diacylglycerol hydrolase activity" RELATED [EC:3.1.1.34] +synonym: "diacylglycerol lipase activity" RELATED [EC:3.1.1.34] +synonym: "diglyceride lipase activity" RELATED [EC:3.1.1.34] +synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] +synonym: "postheparin esterase activity" RELATED [EC:3.1.1.34] +synonym: "postheparin lipase activity" RELATED [EC:3.1.1.34] +synonym: "triacylglycero-protein acylhydrolase activity" RELATED [EC:3.1.1.34] +xref: EC:3.1.1.34 +xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN +xref: Reactome:R-HSA-1482811 "DAG is hydrolyzed to 2-MAG by PNPLA2/3" +xref: Reactome:R-HSA-174757 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols" +xref: Reactome:R-HSA-2395768 "LPL hydrolyses TGs from mature CMs" +xref: Reactome:R-HSA-6789310 "LIPs hydrolyse TG to DAG and RCOOH" +xref: Reactome:R-HSA-8979996 "LIPs hydrolyze TG to DAG and LCFA" +xref: Reactome:R-HSA-8980228 "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA" +is_a: GO:0004806 ! triglyceride lipase activity + +[Term] +id: GO:0004466 +name: long-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.8.8] +synonym: "long-chain acyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.8] +synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" RELATED [EC:1.3.8.8] +synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" RELATED [EC:1.3.8.8] +synonym: "palmitoyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.8] +synonym: "palmitoyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.8] +xref: EC:1.3.8.8 +xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN +xref: RHEA:17721 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0004467 +name: long-chain fatty acid-CoA ligase activity +namespace: molecular_function +alt_id: GO:0003996 +def: "Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [RHEA:15421] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "acyl-activating enzyme activity" BROAD [] +synonym: "acyl-CoA ligase activity" RELATED [] +synonym: "acyl-CoA synthetase activity" RELATED [EC:6.2.1.3] +synonym: "fatty acid thiokinase (long-chain) activity" RELATED [] +synonym: "LCFA synthetase activity" RELATED [] +synonym: "lignoceroyl-CoA synthase activity" RELATED [] +synonym: "long chain fatty acyl-CoA synthetase activity" RELATED [] +synonym: "long-chain acyl CoA synthetase activity" RELATED [] +synonym: "long-chain acyl-CoA synthetase activity" EXACT [] +synonym: "long-chain acyl-coenzyme A synthetase activity" RELATED [] +synonym: "long-chain fatty acid activation" RELATED [] +synonym: "long-chain fatty acyl coenzyme A synthetase activity" RELATED [] +synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] +synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] +synonym: "pristanoyl-CoA synthetase" NARROW [] +synonym: "stearoyl-CoA synthetase" NARROW [] +synonym: "thiokinase" RELATED [] +xref: EC:6.2.1.3 +xref: MetaCyc:ACYLCOASYN-RXN +xref: MetaCyc:PWY-5143 +xref: Reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)" +xref: Reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)" +xref: Reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" +xref: Reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)" +xref: Reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" +xref: Reactome:R-HSA-193711 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)" +xref: Reactome:R-HSA-193727 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" +xref: Reactome:R-HSA-193743 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" +xref: Reactome:R-HSA-193766 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)" +xref: Reactome:R-HSA-201035 "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA" +xref: Reactome:R-HSA-2046085 "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA" +xref: Reactome:R-HSA-2046098 "Activation of linoleic acid to linoleoyl-CoA" +xref: Reactome:R-HSA-548843 "ACSL3,4 ligate CoA to AA to form AA-CoA" +xref: Reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA" +xref: RHEA:15421 +xref: UM-BBD_enzymeID:e0025 +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0004468 +name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] +synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" RELATED [EC:2.3.1.32] +synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.32] +synonym: "LAT activity" RELATED [EC:2.3.1.32] +synonym: "lysine acetyltransferase activity" EXACT [] +synonym: "lysine N(6)-acetyltransferase activity" RELATED [EC:2.3.1.32] +synonym: "lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.32] +xref: EC:2.3.1.32 +xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-5618328 "ATAT acetylates microtubules" +xref: Reactome:R-HSA-5693001 "NAT8,8B acetylate BACE1" +xref: RHEA:14417 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0004470 +name: malic enzyme activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732] +synonym: "pyruvic-malic carboxylase activity" RELATED [EC:1.1.1.39] +is_a: GO:0016615 ! malate dehydrogenase activity + +[Term] +id: GO:0004471 +name: malate dehydrogenase (decarboxylating) (NAD+) activity +namespace: molecular_function +alt_id: GO:0004472 +alt_id: GO:0016619 +def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] +comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. +synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] +synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.39] +synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" RELATED [EC:1.1.1.38] +synonym: "malate dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.39] +synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [] +synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] +synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39] +synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] +xref: EC:1.1.1.38 +xref: EC:1.1.1.39 +xref: KEGG_REACTION:R00214 +xref: MetaCyc:1.1.1.39-RXN +xref: MetaCyc:MALIC-NAD-RXN +xref: Reactome:R-HSA-9012268 "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" +xref: RHEA:12653 +is_a: GO:0004470 ! malic enzyme activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004473 +name: malate dehydrogenase (decarboxylating) (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+." [EC:1.1.1.40] +comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. +synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] +synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" RELATED [EC:1.1.1.40] +synonym: "L-malate:NADP oxidoreductase activity" RELATED [EC:1.1.1.40] +synonym: "malate dehydrogenase (decarboxylating, NADP)" RELATED [EC:1.1.1.40] +synonym: "malate dehydrogenase (NADP, decarboxylating)" RELATED [EC:1.1.1.40] +synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] +synonym: "NADP-malic enzyme activity" RELATED [EC:1.1.1.40] +synonym: "NADP-specific malate dehydrogenase activity" RELATED [EC:1.1.1.40] +synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] +xref: EC:1.1.1.40 +xref: KEGG_REACTION:R00216 +xref: MetaCyc:MALIC-NADP-RXN +xref: Reactome:R-HSA-9012036 "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" +xref: Reactome:R-HSA-9012349 "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" +xref: RHEA:18253 +is_a: GO:0004470 ! malic enzyme activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004474 +name: malate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18181] +comment: Note that this function was formerly EC:4.1.3.2. +synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.9] +synonym: "glyoxylate transacetase activity" RELATED [EC:2.3.3.9] +synonym: "glyoxylate transacetylase activity" RELATED [EC:2.3.3.9] +synonym: "glyoxylic transacetase activity" RELATED [EC:2.3.3.9] +synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.9] +synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] +synonym: "malate synthetase activity" RELATED [EC:2.3.3.9] +synonym: "malic synthetase activity" RELATED [EC:2.3.3.9] +synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] +xref: EC:2.3.3.9 +xref: KEGG_REACTION:R00472 +xref: MetaCyc:MALSYN-RXN +xref: RHEA:18181 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0004475 +name: mannose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15229] +synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] +synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13] +synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13] +synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] +synonym: "guanosine diphosphomannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] +synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.13] +synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" RELATED [EC:2.7.7.13] +synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] +xref: EC:2.7.7.13 +xref: KEGG_REACTION:R00885 +xref: MetaCyc:2.7.7.13-RXN +xref: Reactome:R-HSA-446221 "Mannose-1-phosphate converted to GDP-Mannose" +xref: RHEA:15229 +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0004476 +name: mannose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] +synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.8] +synonym: "D-mannose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.8] +synonym: "mannose phosphate isomerase activity" RELATED [EC:5.3.1.8] +synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] +synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] +synonym: "phosphomannoisomerase activity" RELATED [EC:5.3.1.8] +synonym: "phosphomannose isomerase activity" RELATED [EC:5.3.1.8] +xref: EC:5.3.1.8 +xref: MetaCyc:MANNPISOM-RXN +xref: Reactome:R-HSA-3781832 "Defective MPI does not isomerize Fru6P to Man6P" +xref: Reactome:R-HSA-532549 "MPI isomerises Fru6P to Man6P" +xref: RHEA:12356 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004477 +name: methenyltetrahydrofolate cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] +synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw] +synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" RELATED [EC:3.5.4.9] +synonym: "citrovorum factor cyclodehydrase activity" RELATED [EC:3.5.4.9] +synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" RELATED [EC:3.5.4.9] +xref: EC:3.5.4.9 +xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN +xref: Reactome:R-HSA-200661 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O" +xref: Reactome:R-HSA-200740 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate" +xref: Reactome:R-HSA-6801328 "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF" +xref: RHEA:23700 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0004478 +name: methionine adenosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] +synonym: "adenosylmethionine synthetase activity" RELATED [EC:2.5.1.6] +synonym: "AdoMet synthetase activity" RELATED [EC:2.5.1.6] +synonym: "ATP-methionine adenosyltransferase activity" RELATED [EC:2.5.1.6] +synonym: "ATP:L-methionine S-adenosyltransferase activity" RELATED [EC:2.5.1.6] +synonym: "methionine S-adenosyltransferase activity" RELATED [EC:2.5.1.6] +synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] +synonym: "S-adenosyl-L-methionine synthetase activity" RELATED [EC:2.5.1.6] +synonym: "S-adenosylmethionine synthase activity" RELATED [EC:2.5.1.6] +synonym: "S-adenosylmethionine synthetase activity" RELATED [EC:2.5.1.6] +xref: EC:2.5.1.6 +xref: MetaCyc:S-ADENMETSYN-RXN +xref: Reactome:R-HSA-174391 "MAT1A multimers transfer Ado from ATP to L-Met" +xref: Reactome:R-HSA-5603087 "Defective MAT1A does not transfer Ado from ATP to L-Met" +xref: Reactome:R-HSA-5603114 "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met" +xref: RHEA:21080 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004479 +name: methionyl-tRNA formyltransferase activity +namespace: molecular_function +alt_id: GO:0001718 +alt_id: GO:0070128 +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] +synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" RELATED [EC:2.1.2.9] +synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators] +synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators] +synonym: "formylmethionyl-transfer ribonucleic synthetase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl ribonucleic formyltransferase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-transfer RNA transformylase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-tRNA Met formyltransferase activity" RELATED [EC:2.1.2.9] +synonym: "methionyl-tRNA transformylase activity" RELATED [EC:2.1.2.9] +synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] +synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9] +synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] +synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" RELATED [EC:2.1.2.9] +xref: EC:2.1.2.9 +xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN +xref: Reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA" +xref: RHEA:24380 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0004481 +name: methylene-fatty-acyl-phospholipid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] +synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] +synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" RELATED [EC:2.1.1.16] +synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] +xref: EC:2.1.1.16 +xref: MetaCyc:2.1.1.16-RXN +xref: RHEA:17549 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004482 +name: mRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] +synonym: "guanine-7-methyltransferase activity" RELATED [EC:2.1.1.56] +synonym: "messenger ribonucleate guanine 7-methyltransferase activity" RELATED [EC:2.1.1.56] +synonym: "messenger RNA guanine 7-methyltransferase activity" RELATED [EC:2.1.1.56] +synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" RELATED [EC:2.1.1.56] +synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" RELATED [EC:2.1.1.56] +xref: EC:2.1.1.56 +xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase" +xref: Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs" +xref: Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)" +xref: Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)" +xref: Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs" +xref: Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)" +xref: Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0004483 +name: mRNA (nucleoside-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] +synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" RELATED [EC:2.1.1.57] +synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" RELATED [EC:2.1.1.57] +synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.57] +synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.57] +xref: EC:2.1.1.57 +xref: MetaCyc:2.1.1.57-RXN +xref: Reactome:R-HSA-9684030 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)" +xref: Reactome:R-HSA-9684032 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)" +xref: Reactome:R-HSA-9684033 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs" +xref: Reactome:R-HSA-9694499 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs" +xref: Reactome:R-HSA-9694521 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)" +xref: Reactome:R-HSA-9694721 "nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)" +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0004484 +name: mRNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] +synonym: "GTP--RNA guanylyltransferase activity" RELATED [EC:2.7.7.50] +synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] +synonym: "messenger RNA guanylyltransferase activity" RELATED [EC:2.7.7.50] +synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] +synonym: "protein lambda2" RELATED [EC:2.7.7.50] +xref: EC:2.7.7.50 +xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN +xref: Reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex" +xref: Reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA" +xref: RHEA:54592 +is_a: GO:0008192 ! RNA guanylyltransferase activity + +[Term] +id: GO:0004485 +name: methylcrotonoyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13589] +synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.4] +synonym: "beta-methylcrotonyl CoA carboxylase activity" RELATED [EC:6.4.1.4] +synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.4] +synonym: "beta-methylcrotonyl-CoA carboxylase activity" RELATED [EC:6.4.1.4] +synonym: "MCCC activity" EXACT [GOC:bf] +synonym: "methylcrotonyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.4] +synonym: "methylcrotonyl-CoA carboxylase activity" RELATED [EC:6.4.1.4] +xref: EC:6.4.1.4 +xref: KEGG_REACTION:R04138 +xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN +xref: Reactome:R-HSA-508308 "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]" +xref: Reactome:R-HSA-70773 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]" +xref: RHEA:13589 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0004486 +name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.15] +synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw] +synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.5] +xref: EC:1.5.1.5 +xref: Reactome:R-HSA-200644 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+" +xref: Reactome:R-HSA-200718 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+" +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004487 +name: methylenetetrahydrofolate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22892] +synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.5] +synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" RELATED [EC:1.5.1.15] +xref: EC:1.5.1.15 +xref: KEGG_REACTION:R01218 +xref: MetaCyc:1.5.1.15-RXN +xref: Reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF" +xref: RHEA:22892 +is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004488 +name: methylenetetrahydrofolate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22812] +synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" RELATED [EC:1.5.1.5] +synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.5] +xref: EC:1.5.1.5 +xref: KEGG_REACTION:R01220 +xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN +xref: RHEA:22812 +is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004489 +name: methylenetetrahydrofolate reductase (NAD(P)H) activity +namespace: molecular_function +alt_id: GO:0008702 +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20, PMID:26872964] +synonym: "5,10-CH(2)-H(4)folate reductase activity" RELATED [EC:1.5.1.20] +synonym: "5,10-CH2-H4folate reductase activity" RELATED [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] +synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] +synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" RELATED [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] +synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.20] +synonym: "MetF" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase (NADPH2)" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] +synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] +synonym: "MTHFR activity" BROAD [EC:1.5.1.20] +synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] +synonym: "N5,10-methylenetetrahydrofolate reductase activity" RELATED [EC:1.5.1.20] +synonym: "N5,N10-methylenetetrahydrofolate reductase activity" RELATED [EC:1.5.1.20] +xref: EC:1.5.1.20 +xref: KEGG_REACTION:R01224 +xref: KEGG_REACTION:R07168 +xref: MetaCyc:1.5.1.20-RXN +xref: Reactome:R-HSA-200676 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+" +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004490 +name: methylglutaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21536] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" RELATED [EC:4.2.1.18] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" RELATED [EC:4.2.1.18] +synonym: "3-methylglutaconyl CoA hydratase activity" RELATED [EC:4.2.1.18] +synonym: "methylglutaconase activity" RELATED [EC:4.2.1.18] +synonym: "methylglutaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.18] +xref: EC:4.2.1.18 +xref: KEGG_REACTION:R02085 +xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN +xref: Reactome:R-HSA-70785 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA" +xref: RHEA:21536 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004491 +name: methylmalonate-semialdehyde dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] +synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" RELATED [EC:1.2.1.27] +synonym: "MMSA dehydrogenase activity" RELATED [EC:1.2.1.27] +synonym: "MSDH activity" RELATED [EC:1.2.1.27] +xref: EC:1.2.1.27 +xref: MetaCyc:1.2.1.27-RXN +xref: Reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+" +xref: RHEA:20804 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004492 +name: methylmalonyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:7.2.4.3] +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.3] +synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" RELATED [EC:7.2.4.3] +synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.3] +synonym: "methylmalonyl-coenzyme A decarboxylase activity" RELATED [EC:7.2.4.3] +xref: EC:7.2.4.3 +xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN +xref: RHEA:21396 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004493 +name: methylmalonyl-CoA epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20553] +synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.1] +synonym: "DL-methylmalonyl-CoA racemase activity" RELATED [EC:5.1.99.1] +synonym: "methylmalonyl coenzyme A racemase activity" RELATED [EC:5.1.99.1] +synonym: "methylmalonyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.1] +synonym: "methylmalonyl-CoA racemase activity" RELATED [EC:5.1.99.1] +xref: EC:5.1.99.1 +xref: KEGG_REACTION:R02765 +xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN +xref: Reactome:R-HSA-71020 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA" +xref: RHEA:20553 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0004494 +name: methylmalonyl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22888] +synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.2] +synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.2] +synonym: "(S)-methylmalonyl-CoA mutase activity" RELATED [EC:5.4.99.2] +synonym: "methylmalonyl coenzyme A carbonylmutase activity" RELATED [EC:5.4.99.2] +synonym: "methylmalonyl coenzyme A mutase activity" RELATED [EC:5.4.99.2] +synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" RELATED [EC:5.4.99.2] +xref: EC:5.4.99.2 +xref: KEGG_REACTION:R00833 +xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN +xref: Reactome:R-HSA-3322971 "Defective MUT does not isomerise L-MM-CoA to SUCC-CoA" +xref: Reactome:R-HSA-71010 "MUT isomerises L-MM-CoA to SUCC-CoA" +xref: RHEA:22888 +xref: UM-BBD_reactionID:r0922 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0004495 +name: mevaldate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004496 +name: mevalonate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17065] +synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36] +synonym: "ATP:mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36] +synonym: "mevalonate 5-phosphotransferase activity" RELATED [EC:2.7.1.36] +synonym: "mevalonate kinase (phosphorylating)" RELATED [EC:2.7.1.36] +synonym: "mevalonate phosphokinase activity" RELATED [EC:2.7.1.36] +synonym: "mevalonic acid kinase activity" RELATED [EC:2.7.1.36] +synonym: "mevalonic kinase activity" RELATED [EC:2.7.1.36] +synonym: "MVA kinase activity" RELATED [EC:2.7.1.36] +xref: EC:2.7.1.36 +xref: KEGG_REACTION:R02245 +xref: MetaCyc:MEVALONATE-KINASE-RXN +xref: Reactome:R-HSA-191380 "Mevalonate is phosphorylated to mevalonate-5-phosphate" +xref: RHEA:17065 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004497 +name: monooxygenase activity +namespace: molecular_function +def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [ISBN:0198506732] +subset: goslim_pir +synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk] +xref: Reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde" +xref: Reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO" +xref: Reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone" +xref: Reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA" +xref: Reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation" +xref: Reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2" +xref: Reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA" +xref: Reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole" +xref: Reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide" +xref: Reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b" +xref: Reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST" +xref: Reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA" +xref: Reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM" +xref: Reactome:R-HSA-211968 "CYP2W1 oxidises INDOL" +xref: Reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation" +xref: Reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6" +xref: Reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation" +xref: Reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole" +xref: Reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO" +xref: Reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4" +xref: Reactome:R-HSA-2161795 "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)" +xref: Reactome:R-HSA-2161814 "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)" +xref: Reactome:R-HSA-2161890 "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)" +xref: Reactome:R-HSA-2161899 "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)" +xref: Reactome:R-HSA-2161940 "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)" +xref: Reactome:R-HSA-2162191 "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase" +xref: Reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ" +xref: Reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E" +xref: Reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1" +xref: Reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO" +xref: Reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1" +xref: Reactome:R-HSA-5602242 "Defective CYP2U1 does not omega-hydroxylate ARA" +xref: Reactome:R-HSA-5602272 "Defective CYP4F22 does not 20-hydroxylate TrXA3" +xref: Reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3" +xref: Reactome:R-HSA-5605147 "Defective CYP1B1 does not 4-hydroxylate EST17b" +xref: Reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone" +xref: Reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR" +xref: Reactome:R-HSA-5663050 "DHI and DHICA polymerise forming eumelanin" +xref: Reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE" +xref: Reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide" +xref: Reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl" +xref: Reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP" +xref: Reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" +xref: Reactome:R-HSA-76416 "Benzene is hydroxylated to phenol" +xref: Reactome:R-HSA-76426 "N-atom dealkylation of caffeine" +xref: Reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical" +xref: Reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan" +xref: Reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX" +xref: Reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1" +xref: Reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" +xref: Reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2" +xref: Reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE" +xref: Reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1" +xref: Reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA" +xref: Reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2" +xref: Reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA" +xref: Reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA" +xref: Reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004498 +name: calcidiol 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.15.18, RHEA:20573] +synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxy D3-1alpha-hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] +synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] +synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "25-OHD-1 alpha-hydroxylase activity" RELATED [EC:1.14.15.18] +synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [] +synonym: "cytochrome P450 CYP27B" NARROW [] +xref: EC:1.14.15.18 +xref: KEGG_REACTION:R03610 +xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D" +xref: Reactome:R-HSA-5602186 "Defective CYP27B1 does not hydroxylate CDL" +xref: RHEA:20573 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004499 +name: N,N-dimethylaniline monooxygenase activity +namespace: molecular_function +alt_id: GO:0047076 +def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] +synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" RELATED [EC:1.13.12.11] +synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] +synonym: "dimethylaniline N-oxidase activity" RELATED [EC:1.13.12.11] +synonym: "dimethylaniline oxidase activity" RELATED [EC:1.13.12.11] +synonym: "DMA oxidase activity" RELATED [EC:1.13.12.11] +synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] +synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] +synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] +synonym: "flavin-containing monooxygenase activity" BROAD [EC:1.13.12.11] +synonym: "FMO activity" RELATED [EC:1.13.12.11] +synonym: "FMO-I" RELATED [EC:1.13.12.11] +synonym: "FMO-II" RELATED [EC:1.13.12.11] +synonym: "FMO1" RELATED [EC:1.13.12.11] +synonym: "FMO2" RELATED [EC:1.13.12.11] +synonym: "FMO3" RELATED [EC:1.13.12.11] +synonym: "FMO4" RELATED [EC:1.13.12.11] +synonym: "FMO5" RELATED [EC:1.13.12.11] +synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] +synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] +synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" RELATED [EC:1.13.12.11] +synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] +xref: EC:1.14.13.8 +xref: MetaCyc:1.14.13.8-RXN +xref: Reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO" +xref: Reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM" +xref: Reactome:R-HSA-5602966 "Defective FMO3 does not N-oxidise TMA" +xref: RHEA:24468 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004500 +name: dopamine beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19117] +synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" RELATED [EC:1.14.17.1] +synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" RELATED [EC:1.14.17.1] +synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" RELATED [EC:1.14.17.1] +synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" RELATED [EC:1.14.17.1] +synonym: "dopa beta-hydroxylase activity" RELATED [EC:1.14.17.1] +synonym: "dopamine b-hydroxylase activity" EXACT [] +synonym: "dopamine beta-hydroxylase activity" RELATED [EC:1.14.17.1] +synonym: "dopamine beta-oxidase activity" RELATED [EC:1.14.17.1] +synonym: "dopamine hydroxylase activity" RELATED [EC:1.14.17.1] +synonym: "dopamine-B-hydroxylase activity" RELATED [EC:1.14.17.1] +synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] +synonym: "oxygenase, dopamine beta-mono-" RELATED [EC:1.14.17.1] +synonym: "phenylamine beta-hydroxylase activity" RELATED [EC:1.14.17.1] +synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] +xref: EC:1.14.17.1 +xref: KEGG_REACTION:R02535 +xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-209891 "Dopamine is oxidised to noradrenaline" +xref: RHEA:19117 +is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004501 +name: ecdysone 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14021] +synonym: "alpha-ecdysone C-20 hydroxylase activity" RELATED [EC:1.14.99.22] +synonym: "ecdysone 20-hydroxylase activity" EXACT [] +synonym: "ecdysone modification" BROAD [] +synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" RELATED [EC:1.14.99.22] +xref: EC:1.14.99.22 +xref: KEGG_REACTION:R02374 +xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN +xref: RHEA:14021 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004502 +name: kynurenine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20545] +synonym: "kynurenine 3-hydroxylase activity" EXACT [] +synonym: "kynurenine hydroxylase activity" RELATED [EC:1.14.13.9] +synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.9] +synonym: "L-kynurenine-3-hydroxylase activity" RELATED [EC:1.14.13.9] +xref: EC:1.14.13.9 +xref: KEGG_REACTION:R01960 +xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-71200 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O" +xref: RHEA:20545 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004503 +name: tyrosinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates." [PMID:4965136, RHEA:18117] +comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children. +synonym: "catecholase" RELATED [] +synonym: "chlorogenic acid oxidase activity" RELATED [] +synonym: "chlorogenic oxidase activity" RELATED [] +synonym: "cresolase activity" RELATED [EC:1.14.18.1] +synonym: "dopa oxidase" RELATED [] +synonym: "L-tyrosine monooxygenase activity" EXACT [GOC:bf] +synonym: "monophenol monooxidase activity" RELATED [] +synonym: "monophenol monooxygenase activity" EXACT [EC:1.14.18.1] +synonym: "monophenol oxidase activity" RELATED [EC:1.14.18.1] +synonym: "monophenol oxygenase" EXACT [EC:1.14.18.1, PMID:2494997] +synonym: "monophenolase activity" RELATED [] +synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" RELATED [EC:1.14.18.1] +synonym: "o-diphenol oxidase activity" RELATED [] +synonym: "o-diphenol oxidoreductase" RELATED [] +synonym: "o-diphenol:O2 oxidoreductase activity" RELATED [EC:1.14.18.1] +synonym: "phenol oxidase activity" BROAD [] +synonym: "phenolase activity" BROAD [EC:1.14.18.1] +synonym: "prophenol oxidase activity" RELATED [GOC:sart] +synonym: "prophenoloxidase activity" RELATED [] +synonym: "pyrocatechol oxidase" BROAD [] +synonym: "tyrosine-dopa oxidase activity" RELATED [EC:1.14.18.1] +xref: EC:1.14.18.1 +xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004504 +name: peptidylglycine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] +synonym: "PAM activity" RELATED [EC:1.14.17.3] +synonym: "PAM-A" RELATED [EC:1.14.17.3] +synonym: "PAM-B" RELATED [EC:1.14.17.3] +synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] +synonym: "peptide alpha-amide synthase activity" RELATED [EC:1.14.17.3] +synonym: "peptide-alpha-amide synthetase activity" RELATED [EC:1.14.17.3] +synonym: "peptidyl alpha-amidating enzyme activity" RELATED [EC:1.14.17.3] +synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] +synonym: "peptidylglycine alpha-amidating monooxygenase activity" RELATED [EC:1.14.17.3] +synonym: "peptidylglycine alpha-hydroxylase activity" RELATED [EC:1.14.17.3] +synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.17.3] +synonym: "synthase, peptide alpha-amide" RELATED [EC:1.14.17.3] +xref: EC:1.14.17.3 +xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN +xref: RHEA:21452 +is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004505 +name: phenylalanine 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [PMID:4004813, RHEA:20273] +synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.16.1] +synonym: "PAH activity" RELATED [EC:1.14.16.1] +synonym: "phenylalaninase activity" RELATED [EC:1.14.16.1] +synonym: "phenylalanine 4-hydroxylase activity" RELATED [EC:1.14.16.1] +synonym: "phenylalanine hydroxylase activity" EXACT [] +xref: EC:1.14.16.1 +xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr" +xref: Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr" +xref: RHEA:20273 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004506 +name: squalene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)." [RHEA:25282] +synonym: "squalene 2,3-oxidocyclase activity" RELATED [EC:1.14.14.17] +synonym: "squalene epoxidase activity" RELATED [EC:1.14.14.17] +synonym: "squalene hydroxylase activity" RELATED [EC:1.14.14.17] +synonym: "squalene oxydocyclase activity" RELATED [EC:1.14.14.17] +synonym: "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity" EXACT [KEGG_REACTION:R02874] +synonym: "squalene-2,3-epoxidase activity" RELATED [EC:1.14.14.17] +synonym: "squalene-2,3-epoxide cyclase activity" RELATED [EC:1.14.14.17] +xref: EC:1.14.14.17 +xref: KEGG_REACTION:R02874 +xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-191299 "Squalene is oxidized to its epoxide" +xref: RHEA:25282 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004507 +name: steroid 11-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] +synonym: "cytochrome P450 CYP11B1" NARROW [] +synonym: "cytochrome P450 CYP11B2" NARROW [] +synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] +synonym: "oxygenase, steroid 11beta -mono-" RELATED [EC:1.14.15.4] +synonym: "steroid 11-beta-hydroxylase activity" EXACT [] +synonym: "steroid 11-beta/18-hydroxylase activity" RELATED [EC:1.14.15.4] +synonym: "steroid 11beta-hydroxylase activity" RELATED [EC:1.14.15.4] +synonym: "steroid 11beta-monooxygenase activity" RELATED [EC:1.14.15.4] +synonym: "steroid 11beta/18-hydroxylase activity" RELATED [EC:1.14.15.4] +synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" RELATED [EC:1.14.15.4] +xref: EC:1.14.15.4 +xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT" +xref: Reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST" +xref: Reactome:R-HSA-5580292 "Defective CYP11B1 does not oxidise 11DCORT" +xref: Reactome:R-HSA-5600598 "Defective CYP11B2 does not oxidise 11DCORST" +xref: RHEA:15629 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004508 +name: steroid 17-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.14.19] +synonym: "17alpha-hydroxylase-C17,20 lyase activity" RELATED [EC:1.14.14.19] +synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.14.19] +synonym: "cytochrome P450 CYP17" NARROW [] +synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.14.19] +synonym: "cytochrome P45017alpha" RELATED [EC:1.14.14.19] +synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] +synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] +synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" RELATED [EC:1.14.14.19] +synonym: "steroid 17alpha-hydroxylase activity" RELATED [EC:1.14.14.19] +synonym: "steroid 17alpha-monooxygenase activity" RELATED [EC:1.14.14.19] +synonym: "steroid 17alphahydroxylase/17,20 lyase activity" RELATED [EC:1.14.14.19] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" RELATED [EC:1.14.14.19] +xref: EC:1.14.14.19 +xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-193068 "CYP17A1 17-hydroxylates PREG" +xref: Reactome:R-HSA-193070 "CYP17A1 cleaves 17aHPREG to DHA" +xref: Reactome:R-HSA-193072 "CYP17A1 17-hydroxylates P4 to 17aHPROG" +xref: Reactome:R-HSA-193099 "CYP17A1 cleaves 17aHPROG to ANDST" +xref: Reactome:R-HSA-5601843 "Defective CYP17A1 does not 17-hydroxylate PREG" +xref: Reactome:R-HSA-9035954 "Defective CYP17A1 does not 17-hydroxylate P4" +xref: Reactome:R-HSA-9035956 "Defective CYP17A1 does not cleave 17aHPROG" +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004509 +name: steroid 21-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O." [RHEA:65612] +synonym: "21-hydroxylase activity" RELATED [EC:1.14.14.16] +synonym: "cytochrome P450 CYP21A1" NARROW [] +synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.14.16] +synonym: "steroid 21-hydroxylase activity" EXACT [] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" RELATED [EC:1.14.14.16] +xref: EC:1.14.14.16 +xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-193964 "CYP21A2 21-hydroxylates PROG" +xref: Reactome:R-HSA-193981 "CYP21A2 oxidises 17HPROG" +xref: Reactome:R-HSA-5601976 "Defective CYP21A2 does not 21-hydroxylate PROG" +xref: RHEA:65612 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004510 +name: tryptophan 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] +synonym: "indoleacetic acid-5-hydroxylase activity" RELATED [EC:1.14.16.4] +synonym: "L-tryptophan hydroxylase activity" EXACT [] +synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.16.4] +synonym: "tryptophan 5-hydroxylase activity" RELATED [EC:1.14.16.4] +synonym: "tryptophan hydroxylase activity" RELATED [EC:1.14.16.4] +xref: EC:1.14.16.4 +xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-209828 "Tryptophan is hydroxylated" +xref: RHEA:16709 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004511 +name: tyrosine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] +synonym: "L-tyrosine hydroxylase activity" RELATED [EC:1.14.16.2] +synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.16.2] +synonym: "tyrosine 3-hydroxylase activity" EXACT [] +synonym: "tyrosine hydroxylase activity" EXACT [] +xref: EC:1.14.16.2 +xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-209823 "Tyrosine is hydroxylated to dopa" +xref: RHEA:18201 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004512 +name: inositol-3-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10716] +synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" RELATED [EC:5.5.1.4] +synonym: "D-glucose 6-phosphate cycloaldolase activity" RELATED [EC:5.5.1.4] +synonym: "glucocycloaldolase activity" RELATED [EC:5.5.1.4] +synonym: "glucose 6-phosphate cyclase activity" RELATED [EC:5.5.1.4] +synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" RELATED [EC:5.5.1.4] +synonym: "inositol 1-phosphate synthatase activity" RELATED [EC:5.5.1.4] +synonym: "inositol 1-phosphate synthetase activity" RELATED [EC:5.5.1.4] +xref: EC:5.5.1.4 +xref: KEGG_REACTION:R07324 +xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN +xref: Reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol" +xref: RHEA:10716 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0004513 +name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] +synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" RELATED [EC:2.4.99.10] +synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" RELATED [EC:2.4.99.10] +synonym: "SAT-3" RELATED [EC:2.4.99.10] +synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] +xref: EC:2.4.99.10 +xref: MetaCyc:2.4.99.10-RXN +xref: RHEA:18913 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0004514 +name: nicotinate-nucleotide diphosphorylase (carboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12733] +synonym: "NAD pyrophosphorylase activity" RELATED [EC:2.4.2.19] +synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" RELATED [EC:2.4.2.19] +synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] +synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" RELATED [EC:2.4.2.19] +synonym: "QAPRTase activity" RELATED [EC:2.4.2.19] +synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" RELATED [EC:2.4.2.19] +synonym: "quinolinic acid phosphoribosyltransferase activity" RELATED [EC:2.4.2.19] +synonym: "quinolinic phosphoribosyltransferase activity" RELATED [EC:2.4.2.19] +xref: EC:2.4.2.19 +xref: KEGG_REACTION:R03348 +xref: MetaCyc:QUINOPRIBOTRANS-RXN +xref: Reactome:R-HSA-197268 "QPRT transfers PRIB to QUIN to form NAMN" +xref: RHEA:12733 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004515 +name: nicotinate-nucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] +synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] +synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" RELATED [EC:2.7.7.18] +synonym: "deamido-NAD(+) diphosphorylase activity" RELATED [EC:2.7.7.18] +synonym: "deamido-NAD(+) pyrophosphorylase activity" RELATED [EC:2.7.7.18] +synonym: "deamido-NAD+ pyrophosphorylase activity" RELATED [EC:2.7.7.18] +synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.18] +synonym: "NaMN-ATase activity" RELATED [EC:2.7.7.18] +synonym: "nicotinate mononucleotide adenylyltransferase activity" RELATED [EC:2.7.7.18] +synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] +xref: EC:2.7.7.18 +xref: MetaCyc:NICONUCADENYLYLTRAN-RXN +xref: Reactome:R-HSA-197235 "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD" +xref: Reactome:R-HSA-200474 "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD" +xref: Reactome:R-HSA-200512 "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD" +xref: RHEA:22860 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0004516 +name: nicotinate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [PMID:7503993] +synonym: "niacin ribonucleotidase activity" RELATED [EC:6.3.4.21] +synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:6.3.4.21] +synonym: "nicotinic acid mononucleotide glycohydrolase activity" RELATED [EC:6.3.4.21] +synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" RELATED [EC:6.3.4.21] +synonym: "nicotinic acid phosphoribosyltransferase activity" RELATED [EC:6.3.4.21] +xref: EC:6.3.4.21 +xref: KEGG_REACTION:R01724 +xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN +xref: Reactome:R-HSA-197186 "NAPRT1 dimer transfers PRIB to NCA to form NAMN" +xref: RHEA:36163 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004517 +name: nitric-oxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, RHEA:19897] +synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] +synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] +synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" RELATED [EC:1.14.13.39] +synonym: "NADPH-diaphorase activity" RELATED [EC:1.14.13.39] +synonym: "nitric oxide synthase activity" EXACT [] +synonym: "nitric oxide synthetase activity" RELATED [EC:1.14.13.39] +synonym: "nitric-oxide synthetase activity" RELATED [EC:1.14.13.39] +synonym: "NO synthase activity" RELATED [EC:1.14.13.39] +xref: EC:1.14.13.39 +xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN +xref: Reactome:R-HSA-202127 "eNOS synthesizes NO" +xref: Reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)" +xref: RHEA:19897 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0004518 +name: nuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] +comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_plant +subset: goslim_yeast +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0004519 +name: endonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] +xref: Reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more" +xref: Reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch" +xref: Reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER" +xref: Reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends" +xref: Reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end" +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004520 +name: endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] +synonym: "DNA nicking activity" RELATED [GOC:mah] +synonym: "endonuclease G activity" RELATED [] +xref: Reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site" +xref: Reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop" +xref: Reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA" +xref: Reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ" +xref: Reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER" +xref: Reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)" +xref: Reactome:R-HSA-5693608 "Initial resection of double-strand break ends" +xref: Reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER" +xref: Reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER" +xref: Reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11" +is_a: GO:0004519 ! endonuclease activity +is_a: GO:0004536 ! deoxyribonuclease activity + +[Term] +id: GO:0004521 +name: endoribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] +synonym: "endonuclease G activity" RELATED [] +xref: Reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced" +xref: Reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs" +xref: Reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA" +xref: Reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA" +xref: Reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol" +xref: Reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA" +xref: Reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA" +xref: Reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA" +xref: Reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand" +xref: Reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA" +xref: Reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon" +is_a: GO:0004519 ! endonuclease activity +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0004522 +name: ribonuclease A activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.18] +synonym: "alkaline ribonuclease activity" EXACT [] +synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [] +synonym: "endoribonuclease I" RELATED [] +synonym: "gene S glycoproteins" RELATED [] +synonym: "gene S locus-specific glycoproteins" RELATED [] +synonym: "pancreatic ribonuclease activity" NARROW [EC:4.6.1.18] +synonym: "pancreatic RNase activity" RELATED [EC:4.6.1.18] +synonym: "ribonuclease I activity" RELATED [EC:4.6.1.18] +synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [] +synonym: "ribonucleic phosphatase activity" EXACT [] +synonym: "RNase A activity" RELATED [EC:4.6.1.18] +synonym: "RNase activity" BROAD [EC:4.6.1.18] +synonym: "RNase I activity" RELATED [EC:4.6.1.18] +synonym: "S-genotype-assocd. glycoproteins" RELATED [] +synonym: "SLSG glycoproteins" RELATED [] +xref: EC:4.6.1.18 +xref: MetaCyc:3.1.27.5-RXN +xref: Wikipedia:Ribonuclease_A +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0004523 +name: RNA-DNA hybrid ribonuclease activity +namespace: molecular_function +alt_id: GO:0004524 +def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] +comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. +synonym: "calf thymus ribonuclease H activity" EXACT [] +synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] +synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] +synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] +synonym: "hybrid nuclease activity" RELATED [EC:3.1.26.4] +synonym: "hybrid ribonuclease activity" RELATED [EC:3.1.26.4] +synonym: "hybridase (ribonuclease H)" RELATED [EC:3.1.26.4] +synonym: "hybridase activity" RELATED [EC:3.1.26.4] +synonym: "ribonuclease H activity" EXACT [GOC:vw] +synonym: "ribonuclease H1 activity" NARROW [] +synonym: "ribonuclease H2 activity" NARROW [] +synonym: "ribonuclease H3 activity" NARROW [] +synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" RELATED [EC:3.1.26.4] +synonym: "RNase H activity" EXACT [] +synonym: "RNase H1 activity" NARROW [] +synonym: "RNase H2 activity" NARROW [] +synonym: "RNase H3 activity" NARROW [] +xref: EC:3.1.26.4 +xref: MetaCyc:3.1.26.4-RXN +xref: Reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex" +xref: Reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand" +xref: Reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers" +xref: Reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand" +xref: Reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex" +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004525 +name: ribonuclease III activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] +synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] +synonym: "ribonuclease 3 activity" RELATED [EC:3.1.26.3] +synonym: "RNase III activity" RELATED [EC:3.1.26.3] +xref: EC:3.1.26.3 +xref: MetaCyc:3.1.26.3-RXN +xref: Reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA" +xref: Reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA" +xref: Reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA" +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters +is_a: GO:0032296 ! double-stranded RNA-specific ribonuclease activity + +[Term] +id: GO:0004526 +name: ribonuclease P activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] +synonym: "RNase P" EXACT [] +synonym: "tRNA 5' leader endonuclease activity" EXACT [] +xref: EC:3.1.26.5 +xref: MetaCyc:3.1.26.5-RXN +xref: Reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA" +xref: Wikipedia:RNase_P +is_a: GO:0004549 ! tRNA-specific ribonuclease activity +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004527 +name: exonuclease activity +namespace: molecular_function +alt_id: GO:0008857 +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] +synonym: "exonuclease IX activity" NARROW [] +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0004528 +name: phosphodiesterase I activity +namespace: molecular_function +def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] +synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" RELATED [EC:3.1.4.1] +synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] +synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] +synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] +synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] +synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] +synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] +synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] +synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" RELATED [EC:3.1.4.1] +synonym: "oligonucleate 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.1] +synonym: "orthophosphoric diester phosphohydrolase activity" RELATED [EC:3.1.4.1] +synonym: "PDE I activity" RELATED [EC:3.1.4.1] +synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] +xref: EC:3.1.4.1 +xref: MetaCyc:3.1.4.1-RXN +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004529 +name: exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0004536 ! deoxyribonuclease activity + +[Term] +id: GO:0004530 +name: deoxyribonuclease I activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] +synonym: "alkaline deoxyribonuclease activity" RELATED [EC:3.1.21.1] +synonym: "alkaline DNase activity" RELATED [EC:3.1.21.1] +synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] +synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] +synonym: "deoxyribonucleic phosphatase activity" RELATED [EC:3.1.21.1] +synonym: "DNA depolymerase activity" RELATED [EC:3.1.21.1] +synonym: "DNA endonuclease activity" RELATED [EC:3.1.21.1] +synonym: "DNA nuclease activity" RELATED [EC:3.1.21.1] +synonym: "DNAase activity" RELATED [EC:3.1.21.1] +synonym: "DNase activity" NARROW [EC:3.1.21.1] +synonym: "DNase I" RELATED [EC:3.1.21.1] +synonym: "dornava" RELATED [EC:3.1.21.1] +synonym: "dornavac" RELATED [EC:3.1.21.1] +synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] +synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] +synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] +synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] +synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] +synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] +synonym: "thymonuclease, dornase activity" RELATED [EC:3.1.21.1] +xref: EC:3.1.21.1 +xref: MetaCyc:3.1.21.1-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004531 +name: deoxyribonuclease II activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] +synonym: "acid deoxyribonuclease activity" RELATED [EC:3.1.22.1] +synonym: "acid DNase activity" RELATED [EC:3.1.22.1] +synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" RELATED [EC:3.1.22.1] +synonym: "DNase II activity" RELATED [EC:3.1.22.1] +synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] +synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] +xref: EC:3.1.22.1 +xref: MetaCyc:3.1.22.1-RXN +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0004532 +name: exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +xref: Reactome:R-HSA-429961 "DCPS scavenges the 7-methylguanosine cap of mRNA" +is_a: GO:0004527 ! exonuclease activity +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0004533 +name: exoribonuclease H activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] +synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] +xref: EC:3.1.13.2 +xref: MetaCyc:3.1.13.2-RXN +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004534 +name: 5'-3' exoribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] +xref: EC:3.1.13.- +xref: Reactome:R-HSA-429845 "5' to 3' exoribonuclease hydrolyzes decapped mRNA" +is_a: GO:0008409 ! 5'-3' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0004535 +name: poly(A)-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] +synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4] +synonym: "3'-exoribonuclease activity" RELATED [EC:3.1.13.4] +synonym: "poly(A)-specific RNase activity" EXACT [] +xref: EC:3.1.13.4 +xref: MetaCyc:3.1.13.4-RXN +xref: Reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA" +xref: Reactome:R-HSA-429992 "PARN deadenylates mRNA" +xref: Reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA" +is_a: GO:0000175 ! 3'-5'-exoribonuclease activity + +[Term] +id: GO:0004536 +name: deoxyribonuclease activity +namespace: molecular_function +alt_id: GO:0004537 +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] +synonym: "caspase-activated deoxyribonuclease activity" NARROW [] +xref: Reactome:R-HSA-211247 "Cleavage of DNA by DFF40" +xref: Reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" +xref: Reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" +is_a: GO:0004518 ! nuclease activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0004540 +name: ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] +is_a: GO:0004518 ! nuclease activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0004549 +name: tRNA-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] +synonym: "tRNA-specific RNase activity" EXACT [] +xref: Reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA" +xref: Reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA" +xref: Reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" +xref: Reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" +is_a: GO:0004540 ! ribonuclease activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0004550 +name: nucleoside diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] +synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.6] +synonym: "NDK activity" RELATED [EC:2.7.4.6] +synonym: "nucleoside 5'-diphosphate kinase activity" RELATED [EC:2.7.4.6] +synonym: "nucleoside 5'-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.6] +synonym: "nucleoside diphosphate (UDP) kinase activity" RELATED [EC:2.7.4.6] +synonym: "nucleoside diphosphokinase activity" RELATED [EC:2.7.4.6] +synonym: "nucleoside-diphosphate kinase activity" EXACT [] +synonym: "nucleotide phosphate kinase activity" RELATED [EC:2.7.4.6] +synonym: "UDP kinase activity" RELATED [EC:2.7.4.6] +synonym: "uridine diphosphate kinase activity" RELATED [EC:2.7.4.6] +xref: EC:2.7.4.6 +xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN +xref: Reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP" +xref: Reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)" +xref: Reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)" +xref: Reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)" +xref: Reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)" +xref: Reactome:R-HSA-6806877 "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs" +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0004551 +name: nucleotide diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] +synonym: "dinucleotide nucleotidohydrolase activity" RELATED [EC:3.6.1.9] +synonym: "nucleotide pyrophosphatase activity" EXACT [] +synonym: "nucleotide-sugar pyrophosphatase activity" RELATED [EC:3.6.1.9] +xref: EC:3.6.1.9 +xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN +xref: Reactome:R-HSA-196955 "2xENPP1 hydrolyzes FAD to FMN" +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004552 +name: octanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24620] +synonym: "1-octanol dehydrogenase activity" RELATED [EC:1.1.1.73] +synonym: "octanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.73] +xref: EC:1.1.1.73 +xref: KEGG_REACTION:R02878 +xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN +xref: RHEA:24620 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004553 +name: hydrolase activity, hydrolyzing O-glycosyl compounds +namespace: molecular_function +alt_id: GO:0016800 +def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] +synonym: "O-glucosyl hydrolase activity" EXACT [] +xref: EC:3.2.1.- +xref: Reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" +xref: Reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" +xref: Reactome:R-HSA-9661820 "Bacterial GUSB hydrolyses BDG to BIL" +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0004555 +name: alpha,alpha-trehalase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [PMID:19897915, RHEA:32675] +synonym: "alpha,alpha-trehalose glucohydrolase activity" RELATED [EC:3.2.1.28] +xref: EC:3.2.1.28 +xref: MetaCyc:TREHALA-RXN +xref: Reactome:R-HSA-188985 "trehalose + H2O => 2 D-glucose" +xref: RHEA:32675 +is_a: GO:0015927 ! trehalase activity + +[Term] +id: GO:0004556 +name: alpha-amylase activity +namespace: molecular_function +alt_id: GO:0103025 +def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [PMID:12527308] +synonym: "1,4-alpha-D-glucan glucanohydrolase activity" RELATED [] +synonym: "alpha amylase activity" RELATED [] +synonym: "alpha-amylase activity (releasing maltohexaose)" NARROW [] +synonym: "endoamylase activity" RELATED [] +synonym: "glycogenase activity" BROAD [EC:3.2.1.1] +synonym: "taka-amylase A" RELATED [] +xref: EC:3.2.1.1 +xref: MetaCyc:ALPHA-AMYL-RXN +xref: MetaCyc:RXN-1823 +xref: MetaCyc:RXN-1825 +xref: Reactome:R-HSA-188979 "Digestion of linear starch (amylose) by extracellular amylase" +xref: Reactome:R-HSA-191114 "Digestion of branched starch (amylopectin) by extracellular amylase" +is_a: GO:0016160 ! amylase activity + +[Term] +id: GO:0004557 +name: alpha-galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] +synonym: "alpha-D-galactosidase activity" RELATED [EC:3.2.1.22] +synonym: "alpha-D-galactoside galactohydrolase activity" RELATED [EC:3.2.1.22] +synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] +synonym: "alpha-galactoside galactohydrolase activity" RELATED [EC:3.2.1.22] +synonym: "melibiase activity" EXACT [] +xref: EC:3.2.1.22 +xref: MetaCyc:ALPHAGALACTOSID-RXN +xref: Reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers" +xref: RHEA:28663 +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0004558 +name: alpha-1,4-glucosidase activity +namespace: molecular_function +alt_id: GO:0004562 +alt_id: GO:0016982 +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] +synonym: "acid maltase activity" RELATED [EC:3.2.1.20] +synonym: "alpha-D-glucosidase activity" RELATED [EC:3.2.1.20] +synonym: "alpha-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.20] +synonym: "alpha-glucopyranosidase activity" RELATED [EC:3.2.1.20] +synonym: "alpha-glucosidase II" RELATED [] +synonym: "alpha-glucoside hydrolase activity" RELATED [EC:3.2.1.20] +synonym: "glucoinvertase activity" RELATED [EC:3.2.1.20] +synonym: "glucosidoinvertase activity" RELATED [EC:3.2.1.20] +synonym: "glucosidosucrase activity" RELATED [EC:3.2.1.20] +synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] +synonym: "maltase-glucoamylase activity" RELATED [EC:3.2.1.20] +xref: EC:3.2.1.20 +xref: MetaCyc:MALTODEXGLUCOSID-RXN +xref: Reactome:R-HSA-189053 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose" +xref: Reactome:R-HSA-189102 "maltose + H2O => 2 D-glucose (maltase-glucoamylase)" +xref: Reactome:R-HSA-191101 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)" +xref: Reactome:R-HSA-191108 "maltose + H2O => 2 D-glucose (sucrase-isomaltase)" +xref: Reactome:R-HSA-191116 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)" +xref: Reactome:R-HSA-5659861 "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)" +xref: Reactome:R-HSA-5659879 "Defective SI does not hydrolyze iMal" +xref: Reactome:R-HSA-5659899 "Defective SI does not hydrolyze maltotriose" +xref: Reactome:R-HSA-5659922 "Defective SI does not hydrolyze Mal" +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0004559 +name: alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] +synonym: "1,2-alpha-D-mannosidase activity" NARROW [EC:3.2.1.24] +synonym: "1,2-alpha-mannosidase" NARROW [EC:3.2.1.24] +synonym: "alpha-D-mannopyranosidase activity" RELATED [EC:3.2.1.24] +synonym: "alpha-D-mannosidase activity" RELATED [EC:3.2.1.24] +synonym: "alpha-D-mannoside mannohydrolase activity" RELATED [EC:3.2.1.24] +synonym: "exo-alpha-mannosidase activity" RELATED [EC:3.2.1.24] +synonym: "p-nitrophenyl-alpha-mannosidase activity" NARROW [EC:3.2.1.24] +xref: EC:3.2.1.24 +xref: MetaCyc:3.2.1.24-RXN +xref: Reactome:R-HSA-6799545 "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5" +xref: Reactome:R-HSA-8853686 "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3" +xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended" +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0004560 +name: alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] +synonym: "alpha-fucosidase activity" RELATED [EC:3.2.1.51] +synonym: "alpha-L-fucoside fucohydrolase activity" RELATED [EC:3.2.1.51] +xref: EC:3.2.1.51 +xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN +xref: Reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc" +xref: RHEA:12288 +is_a: GO:0015928 ! fucosidase activity + +[Term] +id: GO:0004561 +name: alpha-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] +synonym: "alpha-acetylglucosaminidase activity" RELATED [EC:3.2.1.50] +synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" RELATED [EC:3.2.1.50] +synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" RELATED [EC:3.2.1.50] +synonym: "N-acetyl-alpha-D-glucosaminidase activity" RELATED [EC:3.2.1.50] +synonym: "N-acetyl-alpha-glucosaminidase activity" RELATED [EC:3.2.1.50] +synonym: "NAG activity" RELATED [EC:3.2.1.50] +xref: EC:3.2.1.50 +xref: MetaCyc:3.2.1.50-RXN +xref: Reactome:R-HSA-1678742 "NAGLU hydrolyses Heparan sulfate chain(4)" +xref: Reactome:R-HSA-2090038 "NAGLU hydrolyses heparan chain(2)" +xref: Reactome:R-HSA-2263496 "Defective NAGLU does not hydrolyse Heparan sulfate chain(4)" +xref: Reactome:R-HSA-9036052 "Defective NAGLU does not hydrolyse heparan chain(2)" +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004563 +name: beta-N-acetylhexosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] +synonym: "beta-acetylaminodeoxyhexosidase activity" RELATED [EC:3.2.1.52] +synonym: "beta-acetylhexosaminidinase activity" RELATED [EC:3.2.1.52] +synonym: "beta-D-hexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "beta-D-N-acetylhexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "beta-hexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "beta-N-acetyl-D-hexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" RELATED [EC:3.2.1.52] +synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] +synonym: "N-acetyl-beta-D-hexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "N-acetyl-beta-glucosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "N-acetyl-beta-hexosaminidase activity" RELATED [EC:3.2.1.52] +synonym: "N-acetylhexosaminidase activity" RELATED [EC:3.2.1.52] +xref: EC:3.2.1.52 +xref: MetaCyc:3.2.1.52-RXN +xref: Reactome:R-HSA-1605595 "Hexosaminidase A cleaves GalNAc from GM2 to form GM3" +xref: Reactome:R-HSA-1605632 "Both hexosaminidase A and B can cleave GalNAc from globoside" +xref: Reactome:R-HSA-1638053 "HEXA cleaves the terminal GalNAc from keratan sulfate" +xref: Reactome:R-HSA-2105001 "HEXA cleaves the terminal GalNAc from DS" +xref: Reactome:R-HSA-2162225 "HEXA cleaves the terminal GalNAc from small HA fragments" +xref: Reactome:R-HSA-3656259 "Defective HEXA does not cleave the terminal GalNAc from DS" +xref: Reactome:R-HSA-3662344 "Defective HEXB does not cleave the terminal GalNAc from DS" +xref: Reactome:R-HSA-9035976 "Defective HEXA does not cleave the terminall GalNAc from small HA fragments" +xref: Reactome:R-HSA-9035978 "Defective HEXA does not cleave the terminal GalNAc from keratan sulfate" +xref: Reactome:R-HSA-9035982 "Defective HEXB does not cleave the terminal GalNAc from HA fragments" +xref: Reactome:R-HSA-9035983 "Defective HEXB does not cleave the terminal GalNAc from keratan sulfate" +xref: Reactome:R-HSA-9638075 "HEXB cleaves the terminal GalNAc from DS" +xref: Reactome:R-HSA-9638076 "HEXB cleaves the terminal GalNAc from small HA fragments" +xref: Reactome:R-HSA-9638078 "HEXB cleaves the terminal GalNAc from keratan sulfate" +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0004564 +name: beta-fructofuranosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985] +synonym: "acid invertase activity" BROAD [] +synonym: "alkaline invertase activity" BROAD [] +synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] +synonym: "beta-fructosidase activity" RELATED [] +synonym: "beta-h-fructosidase activity" RELATED [] +synonym: "fructosylinvertase activity" RELATED [] +synonym: "glucosucrase activity" RELATED [] +synonym: "invertase activity" BROAD [] +synonym: "invertin activity" BROAD [] +synonym: "maxinvert L 1000 activity" RELATED [] +synonym: "saccharase activity" RELATED [] +xref: EC:3.2.1.26 +xref: MetaCyc:RXN-9985 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004565 +name: beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] +comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. +synonym: "beta-D-galactanase activity" RELATED [] +synonym: "beta-D-galactoside galactohydrolase activity" RELATED [] +synonym: "beta-D-lactosidase activity" RELATED [] +synonym: "beta-lactosidase activity" RELATED [] +synonym: "exo-(1->4)-beta-D-galactanase activity" RELATED [EC:3.2.1.23] +synonym: "hydrolact" RELATED [] +xref: EC:3.2.1.23 +xref: MetaCyc:3.2.1.23-RXN +xref: MetaCyc:BGALACT-PWY +xref: Reactome:R-HSA-1605624 "Beta-galactosidase hydrolyses GM1 to GM2" +xref: Reactome:R-HSA-1606312 "Beta-galactosidase can also hydrolyse globosides to form cerebrosides" +xref: Reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan" +xref: Reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase" +xref: Reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)" +xref: Reactome:R-HSA-2265534 "Defective GLB1 does not hydrolyse a glycosaminoglycan" +xref: Reactome:R-HSA-9036061 "Defective GLB1 does not hydrolyse linker chain(2)" +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0004566 +name: beta-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] +synonym: "beta-D-glucuronoside glucuronosohydrolase activity" RELATED [EC:3.2.1.31] +synonym: "beta-glucuronide glucuronohydrolase activity" RELATED [EC:3.2.1.31] +synonym: "exo-beta-D-glucuronidase activity" RELATED [EC:3.2.1.31] +synonym: "glucuronidase activity" RELATED [EC:3.2.1.31] +synonym: "ketodase activity" RELATED [EC:3.2.1.31] +xref: EC:3.2.1.31 +xref: MetaCyc:BETA-GLUCURONID-RXN +xref: Reactome:R-HSA-1678854 "GUSB tetramer hydrolyses CS/HS precursor" +xref: Reactome:R-HSA-2162226 "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc" +xref: Reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2" +xref: Reactome:R-HSA-2318373 "Defective GUSB does not hydrolyse (HA)2" +xref: Reactome:R-HSA-9036068 "Defective GUSB does not hydrolyse GlcA-1,3-GlcNAc" +xref: Reactome:R-HSA-9036070 "Defective GUSB does not hydrolyse CS/HS precursor" +xref: RHEA:17633 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004567 +name: beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] +synonym: "beta-D-mannosidase activity" RELATED [EC:3.2.1.25] +synonym: "beta-D-mannoside mannohydrolase activity" RELATED [EC:3.2.1.25] +synonym: "beta-mannoside mannohydrolase activity" RELATED [EC:3.2.1.25] +synonym: "exo-beta-D-mannanase activity" RELATED [EC:3.2.1.25] +synonym: "mannanase activity" RELATED [EC:3.2.1.25] +synonym: "mannase activity" RELATED [EC:3.2.1.25] +xref: EC:3.2.1.25 +xref: MetaCyc:3.2.1.25-RXN +xref: Reactome:R-HSA-8853710 "MANBA hydrolyses GlcNAc:Man" +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0004568 +name: chitinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] +synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.14] +synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" RELATED [EC:3.2.1.14] +synonym: "chitodextrinase activity" RELATED [EC:3.2.1.14] +synonym: "poly-beta-glucosaminidase activity" RELATED [EC:3.2.1.14] +synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" RELATED [EC:3.2.1.14] +xref: EC:3.2.1.14 +xref: MetaCyc:3.2.1.14-RXN +xref: Reactome:R-HSA-6786421 "CHIA hydrolyses chitin" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004569 +name: glycoprotein endo-alpha-1,2-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] +synonym: "endo-alpha-mannosidase activity" RELATED [EC:3.2.1.130] +synonym: "endomannosidase activity" RELATED [EC:3.2.1.130] +synonym: "glucosyl mannosidase activity" RELATED [EC:3.2.1.130] +synonym: "glucosylmannosidase activity" RELATED [EC:3.2.1.130] +synonym: "glycoprotein glucosylmannohydrolase activity" RELATED [EC:3.2.1.130] +xref: EC:3.2.1.130 +xref: MetaCyc:3.2.1.130-RXN +xref: Reactome:R-HSA-964759 "Alternative endo-mannosidase I route" +xref: RHEA:54824 +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0004571 +name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655] +synonym: "1,2-alpha-mannosidase" RELATED [EC:3.2.1.113] +synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" RELATED [EC:3.2.1.113] +synonym: "exo-alpha-1,2-mannanase activity" RELATED [EC:3.2.1.113] +synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] +synonym: "Man9-mannosidase activity" NARROW [EC:3.2.1.113] +synonym: "ManI activity" NARROW [EC:3.2.1.113] +synonym: "mannose-9 processing alpha-mannosidase activity" NARROW [EC:3.2.1.113] +synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] +synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] +synonym: "mannosidase I" RELATED [EC:3.2.1.113] +xref: EC:3.2.1.113 +xref: KEGG_REACTION:R05982 +xref: KEGG_REACTION:R06722 +xref: MetaCyc:3.2.1.113-RXN +xref: Reactome:R-HSA-4793949 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)" +xref: Reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5" +xref: Reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)" +xref: Reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)" +xref: Reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)" +xref: Reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)" +xref: Reactome:R-HSA-9036008 "Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)" +xref: Reactome:R-HSA-9036011 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)" +xref: Reactome:R-HSA-9036012 "Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)" +xref: Reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2" +xref: Reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2" +xref: Reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2" +xref: Reactome:R-HSA-9696807 "N-glycan mannose trimming of Spike" +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0004572 +name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] +synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" RELATED [EC:3.2.1.114] +synonym: "alpha-(1,3/6)-mannosidase activity" RELATED [EC:3.2.1.114] +synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "exo-1,3-1,6-alpha-mannosidase activity" RELATED [EC:3.2.1.114] +synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" RELATED [EC:3.2.1.114] +synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] +synonym: "ManII activity" NARROW [EC:3.2.1.114] +synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] +synonym: "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity" EXACT [] +synonym: "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity" EXACT [] +synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT [] +xref: EC:3.2.1.114 +xref: MetaCyc:3.2.1.114-RXN +xref: Reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1" +xref: RHEA:56052 +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0004573 +name: Glc3Man9GlcNAc2 oligosaccharide glucosidase activity +namespace: molecular_function +def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] +synonym: "mannosyl-oligosaccharide glucohydrolase activity" RELATED [EC:3.2.1.106] +synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] +synonym: "mannosyl-oligosaccharide glucosidase activity" RELATED [EC:3.2.1.106] +synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] +synonym: "trimming glucosidase I" EXACT [EC:3.2.1.106] +xref: EC:3.2.1.106 +xref: MetaCyc:3.2.1.106-RXN +xref: Reactome:R-HSA-4793947 "Defective MOGS does not cleave glucose from an N-glycosylated protein" +xref: Reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase" +xref: Reactome:R-HSA-9694364 "N-glycan glucose trimming of Spike" +xref: RHEA:55988 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0004574 +name: oligo-1,6-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10] +synonym: "alpha-limit dextrinase activity" RELATED [EC:3.2.1.10] +synonym: "alpha-methylglucosidase activity" RELATED [GOC:rb] +synonym: "dextrin 6-glucanohydrolase activity" RELATED [EC:3.2.1.10] +synonym: "dextrin 6alpha-glucanohydrolase activity" RELATED [EC:3.2.1.10] +synonym: "exo-oligo-1,6-glucosidase activity" RELATED [EC:3.2.1.10] +synonym: "isomaltase activity" RELATED [EC:3.2.1.10] +synonym: "limit dextrinase" RELATED [] +synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" RELATED [EC:3.2.1.10] +synonym: "oligosaccharide alpha-1,6-glucosidase activity" RELATED [EC:3.2.1.10] +synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] +xref: EC:3.2.1.10 +xref: MetaCyc:3.2.1.10-RXN +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0004575 +name: sucrose alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461] +synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD [] +synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD [] +synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48] +synonym: "sucrase activity" RELATED [EC:3.2.1.48] +synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] +synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] +synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] +synonym: "sucrose alpha-glucohydrolase activity" RELATED [EC:3.2.1.48] +synonym: "sucrose hydrolysis" BROAD [] +synonym: "sucrose-alpha-D-glucohydrolase activity" RELATED [EC:3.2.1.48] +xref: EC:3.2.1.48 +xref: KEGG_REACTION:R00802 +xref: MetaCyc:RXN-1461 +xref: Reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose" +xref: Reactome:R-HSA-5659926 "Defective SI does not hydrolyze Suc" +xref: RHEA:33795 +is_a: GO:0004564 ! beta-fructofuranosidase activity +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0004576 +name: oligosaccharyl transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +synonym: "oligosaccharide transferase activity" EXACT [GOC:mah] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0004577 +name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] +synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" RELATED [EC:2.4.1.141] +synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" RELATED [EC:2.4.1.141] +synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.141] +synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.141] +xref: EC:2.4.1.141 +xref: MetaCyc:2.4.1.141-RXN +xref: Reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP" +xref: Reactome:R-HSA-5633241 "Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP" +xref: RHEA:23380 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0004578 +name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] +synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" RELATED [EC:2.4.1.142] +synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.142] +synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" RELATED [EC:2.4.1.142] +xref: EC:2.4.1.142 +xref: MetaCyc:2.4.1.142-RXN +xref: Reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1" +xref: Reactome:R-HSA-4549382 "Defective ALG1 does not transfer the first Man to the N-glycan precursor" +xref: RHEA:13865 +is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity + +[Term] +id: GO:0004579 +name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [RHEA:22980] +synonym: "asparagine N-glycosyltransferase activity" EXACT [] +synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] +synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [] +synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] +synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [] +synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [] +synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [] +synonym: "oligomannosyltransferase activity" RELATED [] +xref: EC:2.4.99.18 +xref: MetaCyc:2.4.1.119-RXN +xref: Reactome:R-HSA-446209 "Transfer of N-glycan to the protein" +xref: Reactome:R-HSA-9694793 "Spike protein gets N-glycosylated" +xref: RHEA:22980 +is_a: GO:0004576 ! oligosaccharyl transferase activity + +[Term] +id: GO:0004581 +name: dolichyl-phosphate beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] +synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.117] +synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" RELATED [EC:2.4.1.117] +xref: EC:2.4.1.117 +xref: MetaCyc:2.4.1.117-RXN +xref: Reactome:R-HSA-446214 "Synthesis of dolichyl-phosphate-glucose" +xref: RHEA:15401 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0004582 +name: dolichyl-phosphate beta-D-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] +synonym: "dolichol phosphate mannose synthase activity" RELATED [EC:2.4.1.83] +synonym: "dolichol-phosphate mannose synthase activity" RELATED [EC:2.4.1.83] +synonym: "dolichol-phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] +synonym: "dolichyl mannosyl phosphate synthase activity" RELATED [EC:2.4.1.83] +synonym: "dolichyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "dolichyl-phosphate mannose synthase activity" RELATED [EC:2.4.1.83] +synonym: "dolichyl-phospho-mannose synthase activity" RELATED [EC:2.4.1.83] +synonym: "DPM synthase activity" EXACT [] +synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "GDPMan:DolP mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" RELATED [EC:2.4.1.83] +synonym: "mannosylphosphodolichol synthase activity" RELATED [EC:2.4.1.83] +synonym: "mannosylphosphoryldolichol synthase activity" RELATED [EC:2.4.1.83] +xref: EC:2.4.1.83 +xref: MetaCyc:2.4.1.83-RXN +xref: Reactome:R-HSA-162721 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose" +xref: Reactome:R-HSA-4717406 "Defective DPM1 does not transfer mannose to DOLP to form DOLPman" +xref: Reactome:R-HSA-4719354 "Defective DPM3 does not transfer mannose to DOLP to form DOLPman" +xref: Reactome:R-HSA-4719375 "Defective DPM2 does not transfer mannose to DOLP to form DOLPman" +xref: RHEA:21184 +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0004583 +name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah] +xref: MetaCyc:RXN-5472 +xref: Reactome:R-HSA-446189 "Addition of a second glucose to the N-glycan precursor by ALG8" +xref: Reactome:R-HSA-446194 "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue" +xref: Reactome:R-HSA-446202 "Addition of the first glucose to the N-glycan precursor by ALG6" +xref: Reactome:R-HSA-4724291 "Defective ALG6 does not add glucose to the N-glycan precursor" +xref: Reactome:R-HSA-4724330 "Defective ALG8 does not add glucose to the N-glycan precursor" +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0004584 +name: obsolete dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] +comment: The reason for obsoletion is that this activity has been replaced by 4 activities in EC, EC:2.4.1.258, EC:2.4.1.259, EC:2.4.1.260, and EC:2.4.1.261. +synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" RELATED [EC:2.4.1.130] +synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.130] +synonym: "oligomannosylsynthase activity" BROAD [EC:2.4.1.130] +xref: EC:2.4.1.130 +xref: MetaCyc:2.4.1.130-RXN +is_obsolete: true +consider: GO:0052917 +consider: GO:0052918 +consider: GO:0052925 +consider: GO:0052926 + +[Term] +id: GO:0004585 +name: ornithine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] +synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.3] +synonym: "carbamylphosphate-ornithine transcarbamylase activity" RELATED [EC:2.1.3.3] +synonym: "citrulline phosphorylase activity" RELATED [EC:2.1.3.3] +synonym: "L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.3] +synonym: "L-ornithine carbamyltransferase activity" RELATED [EC:2.1.3.3] +synonym: "L-ornithine transcarbamylase activity" RELATED [EC:2.1.3.3] +synonym: "ornithine carbamyltransferase activity" RELATED [EC:2.1.3.3] +synonym: "ornithine transcarbamylase activity" RELATED [EC:2.1.3.3] +synonym: "OTC activity" RELATED [EC:2.1.3.3] +synonym: "OTCase activity" RELATED [EC:2.1.3.3] +xref: EC:2.1.3.3 +xref: MetaCyc:ORNCARBAMTRANSFER-RXN +xref: MetaCyc:RXN-13482 +xref: Reactome:R-HSA-70560 "carbamoyl phosphate + ornithine => citrulline + orthophosphate" +xref: RHEA:19513 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0004586 +name: ornithine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22964] +synonym: "L-ornithine carboxy-lyase (putrescine-forming)" RELATED [EC:4.1.1.17] +synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] +synonym: "SpeC" RELATED [EC:4.1.1.17] +xref: EC:4.1.1.17 +xref: KEGG_REACTION:R00670 +xref: MetaCyc:ORNDECARBOX-RXN +xref: Reactome:R-HSA-70692 "ornithine => putrescine + CO2" +xref: RHEA:22964 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004587 +name: ornithine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] +synonym: "GabT" RELATED [EC:2.6.1.13] +synonym: "L-ornithine 5-aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "L-ornithine aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "L-ornithine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "OAT" RELATED [EC:2.6.1.13] +synonym: "ornithine 5-aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine delta-transaminase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine ketoacid aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine transaminase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--2-oxoacid aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--keto acid aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--keto acid transaminase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--oxo acid aminotransferase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine--oxo-acid transaminase activity" RELATED [EC:2.6.1.13] +synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] +synonym: "ornithine:alpha-oxoglutarate transaminase activity" RELATED [EC:2.6.1.13] +xref: EC:2.6.1.13 +xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]" +xref: Reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]" +xref: RHEA:13877 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004588 +name: orotate phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] +synonym: "OPRT activity" RELATED [EC:2.4.2.10] +synonym: "OPRTase activity" RELATED [EC:2.4.2.10] +synonym: "orotate phosphoribosyl pyrophosphate transferase activity" RELATED [EC:2.4.2.10] +synonym: "orotic acid phosphoribosyltransferase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine phosphoribosyltransferase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate diphosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylate phosphoribosyltransferase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylate pyrophosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylic acid phosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylic acid pyrophosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylic phosphorylase activity" RELATED [EC:2.4.2.10] +synonym: "orotidylic pyrophosphorylase activity" RELATED [EC:2.4.2.10] +xref: EC:2.4.2.10 +xref: MetaCyc:OROPRIBTRANS-RXN +xref: Reactome:R-HSA-73567 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate" +xref: RHEA:10380 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004589 +name: orotate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13513] +synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.14] +xref: EC:1.3.1.14 +xref: KEGG_REACTION:R01869 +xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN +xref: RHEA:13513 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004590 +name: orotidine-5'-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11596] +synonym: "ODCase activity" RELATED [EC:4.1.1.23] +synonym: "OMP decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "OMP-DC" RELATED [EC:4.1.1.23] +synonym: "OMPdcase activity" RELATED [EC:4.1.1.23] +synonym: "orotate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotate monophosphate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotic decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidine 5'-phosphate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidine monophosphate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidine phosphate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidine-5'-monophosphate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" RELATED [EC:4.1.1.23] +synonym: "orotidine-5'-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.23] +synonym: "orotidylic acid decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotidylic decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "orotodylate decarboxylase activity" RELATED [EC:4.1.1.23] +synonym: "UMP synthase activity" RELATED [EC:4.1.1.23] +synonym: "uridine 5'-monophosphate synthase activity" RELATED [EC:4.1.1.23] +xref: EC:4.1.1.23 +xref: KEGG_REACTION:R00965 +xref: MetaCyc:OROTPDECARB-RXN +xref: Reactome:R-HSA-73564 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2" +xref: RHEA:11596 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004591 +name: oxoglutarate dehydrogenase (succinyl-transferring) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] +synonym: "2-ketoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "2-oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "2-oxoglutarate: lipoate oxidoreductase activity" RELATED [EC:1.2.4.2] +synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" RELATED [EC:1.2.4.2] +synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" RELATED [EC:1.2.4.2] +synonym: "AKGDH activity" RELATED [EC:1.2.4.2] +synonym: "alpha-ketoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "alpha-ketoglutaric acid dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "alpha-ketoglutaric dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "alpha-oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "ketoglutaric dehydrogenase activity" RELATED [EC:1.2.4.2] +synonym: "OGDC activity" RELATED [EC:1.2.4.2] +synonym: "oxoglutarate decarboxylase activity" RELATED [EC:1.2.4.2] +synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] +synonym: "oxoglutarate dehydrogenase activity" RELATED [EC:1.2.4.2] +xref: EC:1.2.4.2 +xref: MetaCyc:2OXOGLUTDECARB-RXN +xref: RHEA:12188 +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0004592 +name: pantoate-beta-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] +synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.1] +synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.1] +synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] +synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] +synonym: "pantothenate synthetase activity" RELATED [EC:6.3.2.1] +xref: EC:6.3.2.1 +xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN +xref: RHEA:10912 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004593 +name: pantothenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12448] +synonym: "(R)-pantothenate amidohydrolase activity" RELATED [EC:3.5.1.22] +synonym: "pantothenate amidohydrolase activity" RELATED [EC:3.5.1.22] +synonym: "pantothenate hydrolase activity" RELATED [EC:3.5.1.22] +xref: EC:3.5.1.22 +xref: KEGG_REACTION:R02474 +xref: MetaCyc:PANTOTHENASE-RXN +xref: RHEA:12448 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0004594 +name: pantothenate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] +synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" RELATED [EC:2.7.1.33] +synonym: "ATP:pantothenate 4'-phosphotransferase activity" RELATED [EC:2.7.1.33] +synonym: "D-pantothenate kinase activity" RELATED [EC:2.7.1.33] +synonym: "pantothenate kinase (phosphorylating) activity" RELATED [EC:2.7.1.33] +synonym: "pantothenic acid kinase activity" RELATED [EC:2.7.1.33] +xref: EC:2.7.1.33 +xref: MetaCyc:PANTOTHENATE-KIN-RXN +xref: Reactome:R-HSA-196857 "PANK2 phosphorylates PanK" +xref: Reactome:R-HSA-199203 "PANK1/3/4 phosphorylate PanK" +xref: RHEA:16373 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004595 +name: pantetheine-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19801] +synonym: "3'-dephospho-CoA pyrophosphorylase activity" RELATED [EC:2.7.7.3] +synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.3] +synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] +synonym: "dephospho-CoA diphosphorylase activity" RELATED [EC:2.7.7.3] +synonym: "dephospho-CoA pyrophosphorylase activity" RELATED [EC:2.7.7.3] +synonym: "dephospho-coenzyme A pyrophosphorylase activity" RELATED [EC:2.7.7.3] +synonym: "pantetheine phosphate adenylyltransferase activity" RELATED [EC:2.7.7.3] +synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] +synonym: "PPAT activity" RELATED [EC:2.7.7.3] +xref: EC:2.7.7.3 +xref: KEGG_REACTION:R03035 +xref: MetaCyc:PANTEPADENYLYLTRAN-RXN +xref: Reactome:R-HSA-196754 "COASY transfers an adenylyl group from ATP to PPANT" +xref: RHEA:19801 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0004596 +name: peptide alpha-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [GOC:mah, PMID:30054468] +synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [] +synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [] +synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [] +synonym: "beta-endorphin acetyltransferase activity" NARROW [] +synonym: "N(alpha)-acetyltransferase activity" RELATED [] +synonym: "nalpha-acetyltransferase activity" EXACT [] +synonym: "NAT activity" RELATED [] +synonym: "peptide acetyltransferase activity" RELATED [] +synonym: "protein N-terminal acetyltransferase activity" EXACT [] +xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-6814090 "NatC acetylates ARFFRP1" +is_a: GO:0034212 ! peptide N-acetyltransferase activity + +[Term] +id: GO:0004598 +name: peptidylamidoglycolate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] +synonym: "alpha-hydroxyglycine amidating dealkylase activity" RELATED [EC:4.3.2.5] +synonym: "HGAD" RELATED [EC:4.3.2.5] +synonym: "PAL" RELATED [EC:4.3.2.5] +synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" RELATED [EC:4.3.2.5] +synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" RELATED [EC:4.3.2.5] +synonym: "peptidylamidoglycolate peptidylamide-lyase activity" RELATED [EC:4.3.2.5] +synonym: "PGL" RELATED [EC:4.3.2.5] +xref: EC:4.3.2.5 +xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN +xref: RHEA:20924 +is_a: GO:0016842 ! amidine-lyase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004600 +name: obsolete cyclophilin +namespace: molecular_function +def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "cyclophilin" EXACT [] +is_obsolete: true +consider: GO:0003755 +consider: GO:0016018 + +[Term] +id: GO:0004601 +name: peroxidase activity +namespace: molecular_function +alt_id: GO:0016685 +alt_id: GO:0016686 +alt_id: GO:0016687 +alt_id: GO:0016693 +def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [GOC:curators] +subset: goslim_metagenomics +synonym: "bacterial catalase-peroxidase activity" NARROW [] +synonym: "donor:hydrogen-peroxide oxidoreductase activity" RELATED [] +synonym: "eosinophil peroxidase activity" NARROW [] +synonym: "extensin peroxidase" NARROW [] +synonym: "guaiacol peroxidase" NARROW [] +synonym: "heme peroxidase" NARROW [] +synonym: "horseradish peroxidase (HRP)" NARROW [] +synonym: "japanese radish peroxidase" NARROW [] +synonym: "lactoperoxidase activity" NARROW [] +synonym: "MPO" RELATED [] +synonym: "myeloperoxidase activity" NARROW [] +synonym: "oxyperoxidase activity" RELATED [EC:1.11.1.-] +synonym: "peroxidase reaction" EXACT [] +synonym: "protoheme peroxidase" NARROW [] +synonym: "pyrocatechol peroxidase" NARROW [] +synonym: "scopoletin peroxidase" NARROW [] +synonym: "secretory plant peroxidase activity" NARROW [] +synonym: "thiocyanate peroxidase" NARROW [] +synonym: "verdoperoxidase" NARROW [] +xref: EC:1.11.1.- +xref: KEGG_REACTION:R03532 +xref: MetaCyc:PEROXID-RXN +xref: Reactome:R-HSA-1222346 "AhpC reduces H2O2" +xref: Reactome:R-HSA-140359 "PGG2 is reduced to PGH2 by PTGS1" +xref: Reactome:R-HSA-209815 "Tyrosine is monoiodinated" +xref: Reactome:R-HSA-209840 "Two DITs combine to form thyroxine" +xref: Reactome:R-HSA-209925 "DIT and MIT combine to form triiodothyronine" +xref: Reactome:R-HSA-209973 "Tyrosine is diiodinated" +xref: Reactome:R-HSA-2309773 "PGG2 is reduced to PGH2 by PTGS2" +xref: Reactome:R-HSA-2559639 "Collagen type IV sulfilimine cross-linking by peroxidasin" +xref: Reactome:R-HSA-3341296 "GPX7,8 catalyze peroxidation of P4HB (PDI)" +xref: Reactome:R-HSA-350901 "Iodide is organified" +xref: Reactome:R-HSA-5631885 "PRDX1 overoxidizes" +xref: Reactome:R-HSA-6789031 "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" +xref: Reactome:R-HSA-6789126 "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" +xref: Reactome:R-HSA-8855490 "Lactoperoxidase (LPO) produces OSCN-" +xref: Reactome:R-HSA-8933635 "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide" +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0004602 +name: glutathione peroxidase activity +namespace: molecular_function +alt_id: GO:0016224 +def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] +synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.9] +synonym: "GSH peroxidase activity" RELATED [EC:1.11.1.9] +synonym: "non-selenium glutathione peroxidase activity" NARROW [] +synonym: "reduced glutathione peroxidase activity" RELATED [EC:1.11.1.9] +synonym: "selenium-glutathione peroxidase activity" RELATED [EC:1.11.1.9] +xref: EC:1.11.1.9 +xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN +xref: Reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4" +xref: Reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4" +xref: Reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4" +xref: Reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4" +xref: Reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" +xref: Reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" +xref: Reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" +xref: Reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" +xref: Reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O" +xref: Reactome:R-HSA-71676 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" +xref: RHEA:16833 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0004603 +name: phenylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] +synonym: "noradrenalin N-methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "norepinephrine methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "norepinephrine N-methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "phenethanolamine methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "phenethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.28] +synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.28] +xref: EC:2.1.1.28 +xref: MetaCyc:2.1.1.28-RXN +xref: Reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline" +xref: RHEA:12176 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004604 +name: phosphoadenylyl-sulfate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11724] +synonym: "3'-phosphoadenylylsulfate reductase activity" RELATED [EC:1.8.4.8] +synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.8] +synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.8] +synonym: "PAdoPS reductase activity" RELATED [EC:1.8.4.8] +synonym: "PAPS reductase activity" RELATED [EC:1.8.4.8] +synonym: "PAPS reductase, thioredoxin-dependent activity" RELATED [EC:1.8.4.8] +synonym: "PAPS sulfotransferase activity" RELATED [EC:1.8.4.8] +synonym: "phosphoadenosine-phosphosulfate reductase activity" RELATED [EC:1.8.4.8] +synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] +synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" RELATED [EC:1.8.4.8] +synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" RELATED [EC:1.8.4.8] +xref: EC:1.8.4.8 +xref: KEGG_REACTION:R02021 +xref: MetaCyc:1.8.4.8-RXN +xref: RHEA:11724 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0004605 +name: phosphatidate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] +synonym: "CDP diglyceride pyrophosphorylase activity" RELATED [EC:2.7.7.41] +synonym: "CDP-DG" RELATED [EC:2.7.7.41] +synonym: "CDP-diacylglyceride synthetase activity" RELATED [EC:2.7.7.41] +synonym: "CDP-diacylglycerol synthase activity" EXACT [] +synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] +synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] +synonym: "CDP-diglyceride synthase activity" EXACT [] +synonym: "CDP-diglyceride synthetase activity" RELATED [EC:2.7.7.41] +synonym: "CTP-diacylglycerol synthetase activity" RELATED [EC:2.7.7.41] +synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" RELATED [EC:2.7.7.41] +synonym: "CTP:phosphatidate cytidylyltransferase activity" RELATED [EC:2.7.7.41] +synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" RELATED [EC:2.7.7.41] +synonym: "DAG synthetase activity" RELATED [EC:2.7.7.41] +synonym: "phosphatidate cytidyltransferase activity" RELATED [EC:2.7.7.41] +synonym: "phosphatidic acid cytidylyltransferase activity" RELATED [EC:2.7.7.41] +xref: EC:2.7.7.41 +xref: MetaCyc:CDPDIGLYSYN-RXN +xref: Reactome:R-HSA-1483121 "PA is converted to CDP-DAG by CDS1" +xref: Reactome:R-HSA-1483165 "PA is converted to CDP-DAG by CDS2" +xref: RHEA:16229 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0004607 +name: phosphatidylcholine-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] +synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] +synonym: "LCAT activity" RELATED [EC:2.3.1.43] +synonym: "lecithin--cholesterol acyltransferase activity" RELATED [EC:2.3.1.43] +synonym: "lecithin:cholesterol acyltransferase activity" RELATED [EC:2.3.1.43] +synonym: "phosphatidylcholine:sterol O-acyltransferase activity" RELATED [EC:2.3.1.43] +synonym: "phospholipid--cholesterol acyltransferase activity" RELATED [EC:2.3.1.43] +xref: EC:2.3.1.43 +xref: MetaCyc:2.3.1.43-RXN +xref: Reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)" +xref: RHEA:21204 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004608 +name: phosphatidylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11164] +synonym: "lipid methyl transferase activity" RELATED [EC:2.1.1.17] +synonym: "LMTase activity" RELATED [EC:2.1.1.17] +synonym: "PEMT" RELATED [EC:2.1.1.17] +synonym: "phosphatidylethanolamine methyltransferase activity" RELATED [EC:2.1.1.17] +synonym: "phosphatidylethanolamine-N-methylase activity" RELATED [EC:2.1.1.17] +synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" RELATED [EC:2.1.1.17] +synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" RELATED [EC:2.1.1.17] +xref: EC:2.1.1.17 +xref: KEGG_REACTION:R02056 +xref: MetaCyc:2.1.1.17-RXN +xref: Reactome:R-HSA-1483174 "PE is methylated to PC by PEMT" +xref: RHEA:11164 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004609 +name: phosphatidylserine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20828] +synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" RELATED [EC:4.1.1.65] +synonym: "phosphatidyl-L-serine carboxy-lyase activity" RELATED [EC:4.1.1.65] +synonym: "PS decarboxylase activity" RELATED [EC:4.1.1.65] +xref: EC:4.1.1.65 +xref: KEGG_REACTION:R02055 +xref: MetaCyc:PHOSPHASERDECARB-RXN +xref: Reactome:R-HSA-1483212 "PS is decarboxylated to PE by PISD" +xref: RHEA:20828 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004610 +name: phosphoacetylglucosamine mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804] +synonym: "acetylaminodeoxyglucose phosphomutase activity" RELATED [EC:5.4.2.3] +synonym: "acetylglucosamine phosphomutase activity" RELATED [EC:5.4.2.3] +synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.3] +synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.3] +synonym: "N-acetylglucosamine-phosphate mutase activity" RELATED [EC:5.4.2.3] +synonym: "phospho-N-acetylglucosamine mutase activity" RELATED [EC:5.4.2.3] +xref: EC:5.4.2.3 +xref: KEGG_REACTION:R08193 +xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN +xref: Reactome:R-HSA-446185 "Isomerization of GlcNAc6P to GlcNAc1P" +xref: RHEA:23804 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004611 +name: phosphoenolpyruvate carboxykinase activity +namespace: molecular_function +def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.32] +synonym: "PEP carboxykinase activity" RELATED [EC:4.1.1.32] +synonym: "PEPCK activity" RELATED [EC:4.1.1.32] +synonym: "phosphopyruvate carboxylase activity" RELATED [EC:4.1.1.32] +xref: EC:4.1.1.32 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004612 +name: phosphoenolpyruvate carboxykinase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18617] +synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.49] +synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.49] +synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] +synonym: "PEPK" RELATED [EC:4.1.1.49] +synonym: "phosphoenolpyruvate carboxylase (ATP)" RELATED [EC:4.1.1.49] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] +synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] +synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" RELATED [EC:4.1.1.49] +synonym: "phosphopyruvate carboxylase (ATP)" RELATED [EC:4.1.1.49] +xref: EC:4.1.1.49 +xref: KEGG_REACTION:R00341 +xref: MetaCyc:PEPCARBOXYKIN-RXN +xref: RHEA:18617 +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0004613 +name: phosphoenolpyruvate carboxykinase (GTP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] +synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.32] +synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.32] +synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] +synonym: "phosphoenolpyruvic carboxykinase (GTP)" RELATED [EC:4.1.1.32] +synonym: "phosphoenolpyruvic carboxylase (GTP)" RELATED [EC:4.1.1.32] +synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" RELATED [EC:4.1.1.32] +synonym: "phosphopyruvate carboxylase (GTP)" RELATED [EC:4.1.1.32] +xref: EC:4.1.1.32 +xref: MetaCyc:4.1.1.32-RXN +xref: Reactome:R-HSA-372819 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]" +xref: Reactome:R-HSA-70241 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]" +xref: RHEA:10388 +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0004614 +name: phosphoglucomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] +synonym: "alpha-D-glucose 1,6-phosphomutase activity" RELATED [EC:5.4.2.2] +synonym: "glucose phosphomutase activity" RELATED [EC:5.4.2.2] +synonym: "phosphoglucose mutase activity" RELATED [EC:5.4.2.2] +xref: EC:5.4.2.2 +xref: MetaCyc:PHOSPHOGLUCMUT-RXN +xref: Reactome:R-HSA-5609939 "Defective PGM1 does not isomerise G6P to G1P" +xref: Reactome:R-HSA-70272 "PGM:Mg2+ isomerise G6P to G1P" +xref: Reactome:R-HSA-70427 "PGM:Mg2+ isomerise G1P to G6P" +xref: Reactome:R-HSA-9638125 "PGM1:Mg2+ isomerises G1P to G6P" +xref: Reactome:R-HSA-9638127 "PGM1:Mg2+ isomerises G6P to G1P" +xref: RHEA:23536 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004615 +name: phosphomannomutase activity +namespace: molecular_function +alt_id: GO:0008971 +def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11140] +synonym: "alpha-D-mannose 1,6-phosphomutase activity" RELATED [EC:5.4.2.8] +synonym: "D-mannose 1,6-phosphomutase activity" RELATED [EC:5.4.2.8] +synonym: "mannose phosphomutase activity" RELATED [EC:5.4.2.8] +synonym: "phosphomannose mutase activity" RELATED [EC:5.4.2.8] +xref: EC:5.4.2.8 +xref: KEGG_REACTION:R01818 +xref: MetaCyc:PHOSMANMUT-RXN +xref: Reactome:R-HSA-3781926 "Defective PMM2 does not isomerise Man6P to Man1P" +xref: Reactome:R-HSA-446201 "PMM1,2 isomerise Man6P to Man1P" +xref: RHEA:11140 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004616 +name: phosphogluconate dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] +synonym: "6-phospho-D-gluconate dehydrogenase activity" RELATED [EC:1.1.1.44] +synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.44] +synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.44] +synonym: "6-phosphogluconic carboxylase activity" RELATED [EC:1.1.1.44] +synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] +synonym: "6PGD activity" RELATED [EC:1.1.1.44] +synonym: "phosphogluconic acid dehydrogenase activity" RELATED [EC:1.1.1.44] +xref: EC:1.1.1.44 +xref: MetaCyc:6PGLUCONDEHYDROG-RXN +xref: Reactome:R-HSA-71299 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+" +xref: RHEA:10116 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004617 +name: phosphoglycerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] +synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.95] +synonym: "3-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.95] +synonym: "3-phosphoglyceric acid dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "3PHP reductase activity" RELATED [EC:1.1.1.95] +synonym: "alpha-KG reductase activity" RELATED [EC:1.1.1.95] +synonym: "alpha-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "alphaKG reductase activity" RELATED [EC:1.1.1.95] +synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] +synonym: "D-3-phosphoglycerate dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.95] +synonym: "glycerate 3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "glycerate-1,3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "PGDH activity" RELATED [EC:1.1.1.95] +synonym: "phosphoglycerate oxidoreductase activity" RELATED [EC:1.1.1.95] +synonym: "phosphoglyceric acid dehydrogenase activity" RELATED [EC:1.1.1.95] +synonym: "SerA" RELATED [EC:1.1.1.95] +synonym: "SerA 3PG dehydrogenase activity" RELATED [EC:1.1.1.95] +xref: EC:1.1.1.95 +xref: MetaCyc:PGLYCDEHYDROG-RXN +xref: Reactome:R-HSA-977348 "PHGHD tetramer dehydrogenates 3PG" +xref: RHEA:12641 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004618 +name: phosphoglycerate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14801] +synonym: "3-PGK" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglycerate kinase activity" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglycerate phosphokinase activity" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglyceric acid kinase activity" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglyceric acid phosphokinase activity" RELATED [EC:2.7.2.3] +synonym: "3-phosphoglyceric kinase activity" RELATED [EC:2.7.2.3] +synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" RELATED [EC:2.7.2.3] +synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.3] +synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.3] +synonym: "glycerate 3-phosphate kinase activity" RELATED [EC:2.7.2.3] +synonym: "glycerophosphate kinase activity" RELATED [EC:2.7.2.3] +synonym: "PGK" RELATED [EC:2.7.2.3] +synonym: "phosphoglyceric acid kinase activity" RELATED [EC:2.7.2.3] +synonym: "phosphoglyceric kinase activity" RELATED [EC:2.7.2.3] +synonym: "phosphoglycerokinase activity" RELATED [EC:2.7.2.3] +xref: EC:2.7.2.3 +xref: KEGG_REACTION:R01512 +xref: MetaCyc:PHOSGLYPHOS-RXN +xref: Reactome:R-HSA-70486 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate" +xref: Reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ATP" +xref: RHEA:14801 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0004619 +name: phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] +synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] +synonym: "D-phosphoglycerate 2,3-phosphomutase activity" RELATED [EC:5.4.2.1] +synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] +synonym: "GriP mutase" NARROW [EC:5.4.2.1] +synonym: "monophosphoglycerate mutase activity" RELATED [EC:5.4.2.1] +synonym: "monophosphoglyceromutase activity" RELATED [EC:5.4.2.1] +synonym: "MPGM" RELATED [EC:5.4.2.1] +synonym: "PGA mutase activity" RELATED [EC:5.4.2.1] +synonym: "PGAM activity" RELATED [EC:5.4.2.1] +synonym: "PGM" EXACT [] +synonym: "phosphoglycerate phosphomutase activity" RELATED [EC:5.4.2.1] +synonym: "phosphoglyceromutase activity" RELATED [EC:5.4.2.1] +xref: EC:5.4.2.1 +xref: MetaCyc:3PGAREARR-RXN +xref: Reactome:R-HSA-71445 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate" +xref: Reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate" +xref: RHEA:15901 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0004620 +name: phospholipase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732] +subset: goslim_chembl +xref: EC:3.1.1.- +xref: Reactome:R-HSA-6786650 "DDHD1,2 hydrolyse PA" +xref: Reactome:R-HSA-6792445 "LIPH, I hydrolyse PA to 2-acyl LPA" +is_a: GO:0016298 ! lipase activity + +[Term] +id: GO:0004621 +name: glycosylphosphatidylinositol phospholipase D activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] +synonym: "glycoprotein phospholipase D activity" EXACT [] +synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" RELATED [EC:3.1.4.50] +synonym: "GPI-PLD activity" RELATED [EC:3.1.4.50] +synonym: "phosphatidylinositol phospholipase D activity" RELATED [EC:3.1.4.50] +synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" RELATED [EC:3.1.4.50] +synonym: "phosphatidylinositol-specific phospholipase D activity" RELATED [EC:3.1.4.50] +xref: EC:3.1.4.50 +xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN +xref: Reactome:R-HSA-8940388 "GPLD1 hydrolyses GPI-anchors from proteins" +xref: RHEA:10832 +is_a: GO:0004630 ! phospholipase D activity + +[Term] +id: GO:0004622 +name: lysophospholipase activity +namespace: molecular_function +alt_id: GO:0045126 +def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] +subset: goslim_chembl +synonym: "2-lysophosphatidylcholine acylhydrolase activity" RELATED [EC:3.1.1.5] +synonym: "lecithinase B activity" RELATED [EC:3.1.1.5] +synonym: "lecitholipase activity" RELATED [EC:3.1.1.5] +synonym: "lysolecithinase activity" RELATED [EC:3.1.1.5] +synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] +synonym: "lysophosphatidase activity" RELATED [EC:3.1.1.5] +synonym: "lysophosphatidylcholine hydrolase activity" RELATED [EC:3.1.1.5] +synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] +synonym: "phosphatidase B" RELATED [EC:3.1.1.5] +synonym: "phospholipase B activity" RELATED [EC:3.1.1.5] +xref: EC:3.1.1.5 +xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN +xref: Reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C" +xref: Reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C" +xref: Reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]" +xref: Reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C" +xref: Reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]" +xref: Reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C" +xref: Reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho" +xref: Reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho" +xref: Reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho" +xref: Reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho" +xref: RHEA:15177 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004623 +name: phospholipase A2 activity +namespace: molecular_function +alt_id: GO:0102567 +alt_id: GO:0102568 +def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides." [RHEA:15801] +subset: goslim_chembl +synonym: "cytosolic phospholipase A2 activity" NARROW [] +synonym: "lecithinase A activity" RELATED [EC:3.1.1.4] +synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] +synonym: "phosphatidolipase activity" RELATED [EC:3.1.1.4] +synonym: "phosphatidylcholine 2-acylhydrolase activity" RELATED [EC:3.1.1.4] +synonym: "phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)" NARROW [] +synonym: "phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)" NARROW [] +synonym: "secreted phospholipase A2 activity" NARROW [] +xref: EC:3.1.1.4 +xref: MetaCyc:PHOSPHOLIPASE-A2-RXN +xref: MetaCyc:RXN-15067 +xref: Reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)" +xref: Reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]" +xref: Reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A" +xref: Reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)" +xref: Reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)" +xref: Reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]" +xref: Reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A" +xref: Reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)" +xref: Reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]" +xref: Reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]" +xref: Reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]" +xref: Reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" +xref: Reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]" +xref: Reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]" +xref: Reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]" +xref: Reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]" +xref: Reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A" +xref: Reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]" +xref: Reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]" +xref: Reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]" +xref: Reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]" +xref: Reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1" +xref: Reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]" +xref: Reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]" +xref: Reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane" +xref: RHEA:15801 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004624 +name: obsolete secreted phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +synonym: "secreted phospholipase A2 activity" EXACT [] +is_obsolete: true +consider: GO:0004623 +consider: GO:0005576 + +[Term] +id: GO:0004625 +name: obsolete calcium-dependent secreted phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +synonym: "calcium-dependent secreted phospholipase A2 activity" EXACT [] +is_obsolete: true +consider: GO:0005576 +consider: GO:0047498 + +[Term] +id: GO:0004626 +name: obsolete cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +synonym: "cytosolic phospholipase A2 activity" EXACT [] +is_obsolete: true +consider: GO:0004623 +consider: GO:0005829 + +[Term] +id: GO:0004627 +name: obsolete calcium-dependent cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +synonym: "calcium-dependent cytosolic phospholipase A2 activity" EXACT [] +is_obsolete: true +consider: GO:0005829 +consider: GO:0047498 + +[Term] +id: GO:0004628 +name: obsolete calcium-independent cytosolic phospholipase A2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] +comment: This term was made obsolete because it represents component and function information. +synonym: "calcium-independent cytosolic phospholipase A2 activity" EXACT [] +is_obsolete: true +consider: GO:0005829 +consider: GO:0047499 + +[Term] +id: GO:0004629 +name: phospholipase C activity +namespace: molecular_function +alt_id: GO:0042298 +def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, GOC:mah] +synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] +synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] +synonym: "phosphatidase C" RELATED [EC:3.1.4.3] +xref: EC:3.1.4.3 +xref: MetaCyc:PHOSPHOLIPASE-C-RXN +xref: Reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate" +xref: Reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3" +xref: Reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis" +xref: Reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis" +xref: Reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate" +xref: Reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane" +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004630 +name: phospholipase D activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] +subset: goslim_chembl +synonym: "choline phosphatase activity" RELATED [EC:3.1.4.4] +synonym: "lecithinase D activity" RELATED [EC:3.1.4.4] +synonym: "lipophosphodiesterase II activity" RELATED [EC:3.1.4.4] +synonym: "phosphatidylcholine phosphatidohydrolase activity" RELATED [EC:3.1.4.4] +xref: EC:3.1.4.4 +xref: MetaCyc:PHOSCHOL-RXN +xref: Reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6" +xref: Reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2" +xref: Reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD" +xref: RHEA:14445 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004631 +name: phosphomevalonate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16341] +synonym: "5-phosphomevalonate kinase activity" RELATED [EC:2.7.4.2] +synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" RELATED [EC:2.7.4.2] +synonym: "ATP:5-phosphomevalonate phosphotransferase activity" RELATED [EC:2.7.4.2] +synonym: "mevalonate phosphate kinase activity" RELATED [EC:2.7.4.2] +synonym: "mevalonate-5-phosphate kinase activity" RELATED [EC:2.7.4.2] +synonym: "mevalonic acid phosphate kinase activity" RELATED [EC:2.7.4.2] +xref: EC:2.7.4.2 +xref: KEGG_REACTION:R03245 +xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN +xref: Reactome:R-HSA-191422 "Mevalonate-5-phosphate is further phosphorylated." +xref: RHEA:16341 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0004632 +name: phosphopantothenate--cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] +synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" RELATED [EC:6.3.2.5] +synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] +synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] +xref: EC:6.3.2.5 +xref: MetaCyc:P-PANTOCYSLIG-RXN +xref: Reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys" +xref: RHEA:19397 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004633 +name: phosphopantothenoylcysteine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16793] +synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" RELATED [EC:4.1.1.36] +synonym: "4-phosphopantotheoylcysteine decarboxylase activity" RELATED [EC:4.1.1.36] +synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.36] +synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" RELATED [EC:4.1.1.36] +synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.36] +synonym: "PPC-decarboxylase activity" RELATED [EC:4.1.1.36] +xref: EC:4.1.1.36 +xref: KEGG_REACTION:R03269 +xref: MetaCyc:P-PANTOCYSDECARB-RXN +xref: Reactome:R-HSA-196840 "3xPPCDC:3FMN decarboxylates PPC" +xref: RHEA:16793 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004634 +name: phosphopyruvate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732] +synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" RELATED [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate hydro-lyase activity" RELATED [EC:4.2.1.11] +synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] +synonym: "2-phosphoglycerate dehydratase activity" RELATED [EC:4.2.1.11] +synonym: "2-phosphoglycerate enolase activity" RELATED [EC:4.2.1.11] +synonym: "2-phosphoglyceric dehydratase activity" RELATED [EC:4.2.1.11] +synonym: "enolase activity" RELATED [EC:4.2.1.11] +synonym: "gamma-enolase activity" RELATED [EC:4.2.1.11] +synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] +synonym: "phosphoenolpyruvate hydratase activity" RELATED [EC:4.2.1.11] +xref: EC:4.2.1.11 +xref: MetaCyc:2PGADEHYDRAT-RXN +xref: Reactome:R-HSA-70494 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate" +xref: Reactome:R-HSA-71660 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O" +xref: RHEA:10164 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004635 +name: phosphoribosyl-AMP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20049] +synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" RELATED [EC:3.5.4.19] +synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" RELATED [EC:3.5.4.19] +synonym: "PRAMP-cyclohydrolase activity" RELATED [EC:3.5.4.19] +xref: EC:3.5.4.19 +xref: KEGG_REACTION:R04037 +xref: MetaCyc:HISTCYCLOHYD-RXN +xref: RHEA:20049 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0004636 +name: phosphoribosyl-ATP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22828] +synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" RELATED [EC:3.6.1.31] +synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] +synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" RELATED [EC:3.6.1.31] +xref: EC:3.6.1.31 +xref: KEGG_REACTION:R04035 +xref: MetaCyc:HISTPRATPHYD-RXN +xref: RHEA:22828 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004637 +name: phosphoribosylamine-glycine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17453] +synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" RELATED [EC:6.3.4.13] +synonym: "5'-phosphoribosylglycinamide synthetase activity" RELATED [EC:6.3.4.13] +synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" RELATED [EC:6.3.4.13] +synonym: "GAR" RELATED [EC:6.3.4.13] +synonym: "GAR synthetase activity" RELATED [EC:6.3.4.13] +synonym: "GARS activity" RELATED [EC:6.3.4.13] +synonym: "glycinamide ribonucleotide synthetase activity" RELATED [EC:6.3.4.13] +synonym: "glycineamide ribonucleotide synthetase activity" RELATED [EC:6.3.4.13] +synonym: "phosphoribosylglycinamide synthetase activity" RELATED [EC:6.3.4.13] +synonym: "phosphoribosylglycineamide synthetase activity" RELATED [EC:6.3.4.13] +xref: EC:6.3.4.13 +xref: KEGG_REACTION:R04144 +xref: MetaCyc:GLYRIBONUCSYN-RXN +xref: Reactome:R-HSA-73814 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi" +xref: RHEA:17453 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004638 +name: phosphoribosylaminoimidazole carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10792] +synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.21] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" RELATED [EC:4.1.1.21] +synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" RELATED [EC:4.1.1.21] +synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" RELATED [EC:4.1.1.21] +synonym: "ADE2" RELATED [EC:4.1.1.21] +synonym: "AIR carboxylase activity" RELATED [EC:4.1.1.21] +synonym: "class II PurE" RELATED [EC:4.1.1.21] +xref: EC:4.1.1.21 +xref: KEGG_REACTION:R04209 +xref: MetaCyc:AIRCARBOXY-RXN +xref: Reactome:R-HSA-73806 "AIR + CO2 => CAIR" +xref: RHEA:10792 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004639 +name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22628] +synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.2.6] +synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" RELATED [EC:6.3.2.6] +synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.2.6] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" RELATED [EC:6.3.2.6] +synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" RELATED [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" RELATED [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" RELATED [EC:6.3.2.6] +synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" RELATED [EC:6.3.2.6] +synonym: "PurC" RELATED [EC:6.3.2.6] +synonym: "SAICAR synthase activity" RELATED [EC:6.3.2.6] +synonym: "SAICAR synthetase activity" RELATED [EC:6.3.2.6] +synonym: "SAICARs activity" RELATED [EC:6.3.2.6] +xref: EC:6.3.2.6 +xref: KEGG_REACTION:R04591 +xref: MetaCyc:SAICARSYN-RXN +xref: Reactome:R-HSA-73805 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi" +xref: RHEA:22628 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0004640 +name: phosphoribosylanthranilate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21540] +synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] +synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" RELATED [EC:5.3.1.24] +synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.24] +synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" RELATED [EC:5.3.1.24] +synonym: "PRA isomerase activity" RELATED [EC:5.3.1.24] +synonym: "PRAI activity" RELATED [EC:5.3.1.24] +xref: EC:5.3.1.24 +xref: KEGG_REACTION:R03509 +xref: MetaCyc:PRAISOM-RXN +xref: RHEA:21540 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004641 +name: phosphoribosylformylglycinamidine cyclo-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23032] +synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.1] +synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.1] +synonym: "5'-aminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.3.1] +synonym: "AIR synthase activity" RELATED [EC:6.3.3.1] +synonym: "AIR synthetase activity" RELATED [EC:6.3.3.1] +synonym: "AIRS activity" RELATED [EC:6.3.3.1] +synonym: "phosphoribosyl-aminoimidazole synthetase activity" RELATED [EC:6.3.3.1] +synonym: "phosphoribosylaminoimidazole synthetase activity" RELATED [EC:6.3.3.1] +xref: EC:6.3.3.1 +xref: KEGG_REACTION:R04208 +xref: MetaCyc:AIRS-RXN +xref: Reactome:R-HSA-73810 "FGAM + ATP => AIR + ADP + Pi" +xref: RHEA:23032 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0004642 +name: phosphoribosylformylglycinamidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17129] +synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3] +synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3] +synonym: "FGAM synthase activity" RELATED [EC:6.3.5.3] +synonym: "FGAM synthetase activity" RELATED [EC:6.3.5.3] +synonym: "FGAR amidotransferase activity" RELATED [EC:6.3.5.3] +synonym: "FGARAT activity" RELATED [EC:6.3.5.3] +synonym: "formylglycinamide ribonucloetide amidotransferase activity" RELATED [EC:6.3.5.3] +synonym: "formylglycinamide ribotide amidotransferase activity" RELATED [EC:6.3.5.3] +synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.3] +synonym: "phosphoribosylformylglycinamidine synthetase activity" RELATED [EC:6.3.5.3] +synonym: "phosphoribosylformylglycineamidine synthetase activity" RELATED [EC:6.3.5.3] +xref: EC:6.3.5.3 +xref: KEGG_REACTION:R04463 +xref: MetaCyc:FGAMSYN-RXN +xref: Reactome:R-HSA-73812 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi" +xref: RHEA:17129 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0004643 +name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] +synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" RELATED [EC:2.1.2.3] +synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" RELATED [EC:2.1.2.3] +synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" RELATED [EC:2.1.2.3] +synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" RELATED [EC:2.1.2.3] +synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.3] +synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" RELATED [EC:2.1.2.3] +synonym: "AICAR formyltransferase activity" RELATED [EC:2.1.2.3] +synonym: "AICAR transformylase activity" RELATED [EC:2.1.2.3] +synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.3] +xref: EC:2.1.2.3 +xref: MetaCyc:AICARTRANSFORM-RXN +xref: Reactome:R-HSA-73798 "AICAR + 10-Formyl-THF => FAICAR + THF" +xref: RHEA:22192 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004644 +name: phosphoribosylglycinamide formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] +synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" RELATED [EC:2.1.2.2] +synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" RELATED [EC:2.1.2.2] +synonym: "5'-phosphoribosylglycinamide transformylase activity" RELATED [EC:2.1.2.2] +synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.2] +synonym: "GAR formyltransferase activity" RELATED [EC:2.1.2.2] +synonym: "GAR TFase activity" RELATED [EC:2.1.2.2] +synonym: "GAR transformylase activity" RELATED [EC:2.1.2.2] +synonym: "GART activity" RELATED [EC:2.1.2.2] +synonym: "glycinamide ribonucleotide transformylase activity" RELATED [EC:2.1.2.2] +xref: EC:2.1.2.2 +xref: MetaCyc:GART-RXN +xref: Reactome:R-HSA-73813 "GAR + 10-Formyl-THF => FGAR + THF" +xref: RHEA:15053 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0004645 +name: 1,4-alpha-oligoglucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] +synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.1] +synonym: "1,4-alpha-glucan phosphorylase activity" RELATED [EC:2.4.1.1] +synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] +synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] +synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] +synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] +synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] +synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] +synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] +synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] +synonym: "myophosphorylase" NARROW [EC:2.4.1.1] +synonym: "polyphosphorylase activity" RELATED [EC:2.4.1.1] +synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] +synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] +xref: EC:2.4.1.1 +xref: MetaCyc:RXN-1826 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0004648 +name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +alt_id: GO:0004646 +def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] +synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.52] +synonym: "3-phosphoserine aminotransferase activity" RELATED [EC:2.6.1.52] +synonym: "3PHP transaminase activity" RELATED [EC:2.6.1.52] +synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" RELATED [EC:2.6.1.52] +synonym: "L-phosphoserine aminotransferase activity" RELATED [EC:2.6.1.52] +synonym: "PdxC" RELATED [EC:2.6.1.52] +synonym: "phosphohydroxypyruvate transaminase activity" RELATED [EC:2.6.1.52] +synonym: "phosphohydroxypyruvic--glutamic transaminase activity" RELATED [EC:2.6.1.52] +synonym: "phosphoserine aminotransferase activity" BROAD [] +synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52] +synonym: "PSAT activity" RELATED [EC:2.6.1.52] +synonym: "SerC" RELATED [EC:2.6.1.52] +xref: EC:2.6.1.52 +xref: MetaCyc:PSERTRANSAM-RXN +xref: Reactome:R-HSA-977333 "PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA" +xref: RHEA:14329 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004649 +name: poly(ADP-ribose) glycohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] +xref: EC:3.2.1.143 +xref: MetaCyc:3.2.1.143-RXN +xref: Reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2" +xref: Reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)" +xref: RHEA:52216 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004650 +name: polygalacturonase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] +synonym: "endo-D-galacturonase activity" EXACT [] +synonym: "endo-polygalacturonase activity" EXACT [] +synonym: "endogalacturonase activity" EXACT [] +synonym: "endopolygalacturonase activity" EXACT [] +synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] +synonym: "pectin hydrolase activity" RELATED [EC:3.2.1.15] +synonym: "pectin polygalacturonase activity" RELATED [EC:3.2.1.15] +synonym: "pectinase activity" NARROW [EC:3.2.1.15] +synonym: "pectolase activity" RELATED [EC:3.2.1.15] +synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] +synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] +xref: EC:3.2.1.15 +xref: MetaCyc:RXN-2103 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0004651 +name: polynucleotide 5'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] +synonym: "5'-polynucleotidase activity" RELATED [EC:3.1.3.33] +synonym: "polynucleotide 5'-phosphohydrolase activity" RELATED [EC:3.1.3.33] +synonym: "polynucleotide 5'-triphosphatase activity" RELATED [EC:3.1.3.33] +xref: EC:3.1.3.33 +xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN +xref: Reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme" +xref: RHEA:11008 +is_a: GO:0098518 ! polynucleotide phosphatase activity + +[Term] +id: GO:0004652 +name: polynucleotide adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] +synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" RELATED [EC:2.7.7.19] +synonym: "AMP polynucleotidylexotransferase activity" RELATED [EC:2.7.7.19] +synonym: "ATP-polynucleotide adenylyltransferase activity" RELATED [EC:2.7.7.19] +synonym: "ATP:polynucleotide adenylyltransferase activity" RELATED [EC:2.7.7.19] +synonym: "ATP:polynucleotidylexotransferase activity" RELATED [EC:2.7.7.19] +synonym: "NTP polymerase activity" RELATED [EC:2.7.7.19] +synonym: "poly(A) hydrolase activity" RELATED [EC:2.7.7.19] +synonym: "poly(A) polymerase activity" RELATED [EC:2.7.7.19] +synonym: "poly(A) synthetase activity" RELATED [EC:2.7.7.19] +synonym: "poly-A polymerase activity" RELATED [EC:2.7.7.19] +synonym: "polyadenylate nucleotidyltransferase activity" RELATED [EC:2.7.7.19] +synonym: "polyadenylate polymerase activity" RELATED [EC:2.7.7.19] +synonym: "polyadenylate synthetase activity" RELATED [EC:2.7.7.19] +synonym: "polyadenylic acid polymerase activity" RELATED [EC:2.7.7.19] +synonym: "polyadenylic polymerase activity" RELATED [EC:2.7.7.19] +synonym: "RNA adenylating enzyme activity" RELATED [EC:2.7.7.19] +synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] +synonym: "terminal riboadenylate transferase activity" RELATED [EC:2.7.7.19] +xref: EC:2.7.7.19 +xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN +xref: Reactome:R-HSA-72185 "mRNA polyadenylation" +xref: RHEA:11332 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0004653 +name: polypeptide N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] +synonym: "glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "polypeptide-N-acetylgalactosamine transferase activity" RELATED [EC:2.4.1.41] +synonym: "protein-UDP acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" RELATED [EC:2.4.1.41] +synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.41] +xref: EC:2.4.1.41 +xref: MetaCyc:2.4.1.41-RXN +xref: Reactome:R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins" +xref: Reactome:R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins" +xref: Reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23" +xref: Reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens" +xref: Reactome:R-HSA-9683760 "GalNAc is transferred onto 3a" +xref: Reactome:R-HSA-9694438 "GalNAc is transferred onto 3a" +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004654 +name: polyribonucleotide nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate." [EC:2.7.7.8] +synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" RELATED [EC:2.7.7.8] +synonym: "polynucleotide phosphorylase activity" RELATED [EC:2.7.7.8] +synonym: "polyribonucleotide phosphorylase activity" RELATED [EC:2.7.7.8] +synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.8] +xref: EC:2.7.7.8 +xref: MetaCyc:2.7.7.8-RXN +xref: RHEA:22096 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0004655 +name: porphobilinogen synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24064] +synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" RELATED [EC:4.2.1.24] +synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" RELATED [EC:4.2.1.24] +synonym: "5-levulinic acid dehydratase activity" RELATED [EC:4.2.1.24] +synonym: "aminolevulinate dehydratase activity" EXACT [] +synonym: "aminolevulinic dehydratase activity" RELATED [EC:4.2.1.24] +synonym: "delta-aminolevulinate dehydratase activity" RELATED [EC:4.2.1.24] +synonym: "delta-aminolevulinic acid dehydrase activity" RELATED [EC:4.2.1.24] +synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] +synonym: "delta-aminolevulinic dehydratase activity" RELATED [EC:4.2.1.24] +xref: EC:4.2.1.24 +xref: KEGG_REACTION:R00036 +xref: MetaCyc:PORPHOBILSYNTH-RXN +xref: Reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG" +xref: RHEA:24064 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004656 +name: procollagen-proline 4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] +synonym: "collagen proline hydroxylase activity" RELATED [EC:1.14.11.2] +synonym: "hydroxylase, collagen proline activity" RELATED [EC:1.14.11.2] +synonym: "peptidyl proline hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" RELATED [EC:1.14.11.2] +synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] +synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "proline protocollagen hydroxylase activity" RELATED [EC:1.14.11.2] +synonym: "proline, 2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.2] +synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD [EC:1.14.11.2] +synonym: "prolylprotocollagen dioxygenase activity" RELATED [EC:1.14.11.2] +synonym: "prolylprotocollagen hydroxylase activity" RELATED [EC:1.14.11.2] +synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] +synonym: "protocollagen proline 4-hydroxylase activity" RELATED [EC:1.14.11.2] +synonym: "protocollagen proline dioxygenase activity" RELATED [EC:1.14.11.2] +synonym: "protocollagen proline hydroxylase activity" RELATED [EC:1.14.11.2] +synonym: "protocollagen prolyl hydroxylase activity" RELATED [EC:1.14.11.2] +xref: EC:1.14.11.2 +xref: KEGG_REACTION:R03219 +xref: MetaCyc:1.14.11.2-RXN +xref: Reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines" +xref: RHEA:18945 +is_a: GO:0019798 ! procollagen-proline dioxygenase activity +is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity + +[Term] +id: GO:0004657 +name: proline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] +synonym: "L-proline dehydrogenase activity" RELATED [EC:1.5.99.8] +synonym: "L-proline:(acceptor) oxidoreductase activity" RELATED [EC:1.5.99.8] +synonym: "L-proline:acceptor oxidoreductase activity" RELATED [EC:1.5.99.8] +xref: EC:1.5.99.8 +xref: MetaCyc:RXN-7181 +xref: Reactome:R-HSA-6784224 "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate" +xref: Reactome:R-HSA-70670 "PRODH oxidises L-Pro to 1PYR-5COOH" +xref: Reactome:R-HSA-8955817 "PRODH2 oxidises HPRO to 1PYR-5COOH" +xref: RHEA:23784 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0004658 +name: propionyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] +synonym: "PCCase activity" RELATED [EC:6.4.1.3] +synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.3] +synonym: "propionyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.3] +xref: EC:6.4.1.3 +xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN +xref: Reactome:R-HSA-71031 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate" +xref: RHEA:23720 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0004659 +name: prenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] +xref: MetaCyc:GPPSYN-RXN +xref: Reactome:R-HSA-6806674 "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)" +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004660 +name: protein farnesyltransferase activity +namespace: molecular_function +alt_id: GO:0018223 +def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] +comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate. +synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] +synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" RELATED [EC:2.5.1.58] +synonym: "FTase activity" RELATED [EC:2.5.1.58] +synonym: "protein-cysteine farnesyltransferase activity" EXACT [] +xref: EC:2.5.1.58 +xref: MetaCyc:2.5.1.58-RXN +xref: Reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1" +xref: Reactome:R-HSA-9647978 "pro-RAS proteins are farnesylated" +xref: RHEA:13345 +is_a: GO:0008318 ! protein prenyltransferase activity + +[Term] +id: GO:0004661 +name: protein geranylgeranyltransferase activity +namespace: molecular_function +alt_id: GO:0018224 +def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] +synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] +is_a: GO:0008318 ! protein prenyltransferase activity + +[Term] +id: GO:0004662 +name: CAAX-protein geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] +synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] +synonym: "geranylgeranyltransferase type I activity" EXACT [] +synonym: "GGTase-I activity" EXACT [] +synonym: "GGTaseI activity" EXACT [] +synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] +synonym: "type I protein geranyl-geranyltransferase activity" RELATED [EC:2.5.1.59] +xref: EC:2.5.1.59 +xref: MetaCyc:2.5.1.60-RXN +xref: MetaCyc:RXN-3701 +is_a: GO:0004661 ! protein geranylgeranyltransferase activity + +[Term] +id: GO:0004663 +name: Rab geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] +synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] +synonym: "GGTase-II activity" EXACT [] +synonym: "GGTaseII activity" EXACT [] +synonym: "protein geranylgeranyltransferase type II activity" EXACT [] +synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] +synonym: "RabGGTase activity" EXACT [] +synonym: "type II protein geranyl-geranyltransferase activity" RELATED [EC:2.5.1.60] +xref: EC:2.5.1.60 +xref: MetaCyc:2.5.1.60-RXN +xref: MetaCyc:RXN-3701 +is_a: GO:0004661 ! protein geranylgeranyltransferase activity + +[Term] +id: GO:0004664 +name: prephenate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] +synonym: "prephenate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.51] +synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" RELATED [EC:4.2.1.51] +xref: EC:4.2.1.51 +xref: MetaCyc:PREPHENATEDEHYDRAT-RXN +xref: RHEA:21648 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004665 +name: prephenate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21640] +synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.3.1.13] +synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.13] +xref: EC:1.3.1.13 +xref: KEGG_REACTION:R01730 +xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:21640 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004666 +name: prostaglandin-endoperoxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] +synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.99.1] +synonym: "(PG)H synthase activity" RELATED [EC:1.14.99.1] +synonym: "fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1] +synonym: "PG synthetase activity" RELATED [EC:1.14.99.1] +synonym: "prostaglandin endoperoxide synthetase activity" RELATED [EC:1.14.99.1] +synonym: "prostaglandin G/H synthase activity" RELATED [EC:1.14.99.1] +synonym: "prostaglandin synthase activity" RELATED [EC:1.14.99.1] +synonym: "prostaglandin synthetase activity" RELATED [EC:1.14.99.1] +xref: EC:1.14.99.1 +xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN +xref: Reactome:R-HSA-140355 "Arachidonic acid is oxidised to PGG2 by PTGS1" +xref: Reactome:R-HSA-2309787 "Arachidonic acid is oxidised to PGG2 by PTGS2" +xref: RHEA:23728 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0004667 +name: prostaglandin-D synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10600] +synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" RELATED [EC:5.3.99.2] +synonym: "PGD2 synthase activity" RELATED [EC:5.3.99.2] +synonym: "PGH-PGD isomerase activity" RELATED [EC:5.3.99.2] +synonym: "prostaglandin D2 synthase activity" RELATED [EC:5.3.99.2] +synonym: "prostaglandin-H2 D-isomerase activity" RELATED [EC:5.3.99.2] +synonym: "prostaglandin-R-prostaglandin D isomerase activity" RELATED [EC:5.3.99.2] +xref: EC:5.3.99.2 +xref: KEGG_REACTION:R02266 +xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN +xref: Reactome:R-HSA-2161620 "PGH2 is isomerised to PGD2 by PTGDS" +xref: Reactome:R-HSA-2161701 "PGH2 is isomerised to PGD2 by HPGDS" +xref: RHEA:10600 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0004668 +name: protein-arginine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. This reaction is calcium-dependent." [PMID:27393304] +synonym: "peptidylarginine deiminase activity" RELATED [EC:3.5.3.15] +synonym: "protein-L-arginine iminohydrolase activity" RELATED [EC:3.5.3.15] +xref: EC:3.5.3.15 +xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN +xref: Reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins" +xref: Reactome:R-HSA-3247569 "PADI4 deiminates Histones" +xref: RHEA:18089 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004671 +name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0018225 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] +synonym: "farnesyl cysteine C-terminal methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "farnesyl-protein carboxymethyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "farnesylated protein C-terminal O-methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "isoprenylated protein methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylated protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylated protein methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylcysteine carboxymethyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "prenylcysteine methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" RELATED [EC:2.1.1.100] +synonym: "S-farnesylcysteine methyltransferase activity" RELATED [EC:2.1.1.100] +xref: EC:2.1.1.100 +xref: KEGG_REACTION:R04496 +xref: MetaCyc:2.1.1.100-RXN +xref: Reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins" +xref: Reactome:R-HSA-9647977 "ICMT methylates S-Farn RAS proteins" +xref: RHEA:21672 +is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004672 +name: protein kinase activity +namespace: molecular_function +alt_id: GO:0050222 +def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] +comment: Note that triphosphate is used as a phosphate donor by at least one kinase. +subset: goslim_aspergillus +subset: goslim_candida +synonym: "protamine kinase activity" NARROW [] +xref: MetaCyc:PROTEIN-KINASE-RXN +xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" +xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" +xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" +xref: Reactome:R-HSA-9673284 "GTP-bound RAC1 contributes to MAPK8 activation" +xref: Reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004673 +name: protein histidine kinase activity +namespace: molecular_function +alt_id: GO:0008896 +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] +synonym: "ATP:protein-L-histidine N-phosphotransferase activity" RELATED [EC:2.7.13.3] +synonym: "EnvZ" NARROW [EC:2.7.13.3] +synonym: "histidine kinase (ambiguous)" RELATED [EC:2.7.13.3] +synonym: "histidine kinase activity" EXACT [] +synonym: "histidine protein kinase (ambiguous)" RELATED [EC:2.7.13.3] +synonym: "histidine protein kinase activity" RELATED [EC:2.7.13.3] +synonym: "HK1" RELATED [EC:2.7.13.3] +synonym: "HP165" RELATED [EC:2.7.13.3] +synonym: "protein histidine kinase (ambiguous)" RELATED [EC:2.7.13.3] +synonym: "protein kinase (histidine)" RELATED [EC:2.7.13.3] +synonym: "protein kinase (histidine) (ambiguous)" RELATED [EC:2.7.13.3] +synonym: "protein-histidine kinase activity" EXACT [] +synonym: "Sln1p" NARROW [EC:2.7.13.3] +xref: EC:2.7.13.3 +xref: MetaCyc:2.7.13.3-RXN +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0004674 +name: protein serine/threonine kinase activity +namespace: molecular_function +alt_id: GO:0004695 +alt_id: GO:0004696 +alt_id: GO:0004700 +alt_id: GO:0106311 +def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, PMID:2956925] +synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] +synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] +synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "protein serine-threonine kinase activity" RELATED [EC:2.7.11.1] +synonym: "protein threonine kinase activity" NARROW [] +synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine(threonine) protein kinase activity" RELATED [EC:2.7.11.1] +synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] +synonym: "serine/threonine protein kinase activity" RELATED [EC:2.7.11.1] +synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] +xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" +xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" +xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" +xref: Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" +xref: Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" +xref: Reactome:R-HSA-111919 "PKA phosphorylates CREB1" +xref: Reactome:R-HSA-111970 "PKC phosphorylates GRK2" +xref: Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" +xref: Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" +xref: Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" +xref: Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" +xref: Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" +xref: Reactome:R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" +xref: Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" +xref: Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" +xref: Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" +xref: Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" +xref: Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" +xref: Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" +xref: Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" +xref: Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" +xref: Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" +xref: Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" +xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" +xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" +xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" +xref: Reactome:R-HSA-156678 "Activation of Cdc25C" +xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC" +xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase" +xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" +xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" +xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" +xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase" +xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" +xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex" +xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" +xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" +xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" +xref: Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" +xref: Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" +xref: Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" +xref: Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" +xref: Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" +xref: Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" +xref: Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" +xref: Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" +xref: Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" +xref: Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" +xref: Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" +xref: Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" +xref: Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" +xref: Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" +xref: Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" +xref: Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" +xref: Reactome:R-HSA-168140 "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex" +xref: Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" +xref: Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" +xref: Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" +xref: Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" +xref: Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" +xref: Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" +xref: Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" +xref: Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" +xref: Reactome:R-HSA-176116 "Recruitment and activation of Chk1" +xref: Reactome:R-HSA-176298 "Activation of claspin" +xref: Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" +xref: Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" +xref: Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" +xref: Reactome:R-HSA-193647 "IRAK is activated" +xref: Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" +xref: Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" +xref: Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" +xref: Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" +xref: Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" +xref: Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" +xref: Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" +xref: Reactome:R-HSA-198347 "AKT phosphorylates BAD" +xref: Reactome:R-HSA-198371 "AKT phosphorylates GSK3" +xref: Reactome:R-HSA-198599 "AKT phosphorylates MDM2" +xref: Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" +xref: Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" +xref: Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" +xref: Reactome:R-HSA-198621 "AKT phosphorylates caspase-9" +xref: Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" +xref: Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" +xref: Reactome:R-HSA-198731 "ERK1/2 activates ELK1" +xref: Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" +xref: Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" +xref: Reactome:R-HSA-199298 "AKT phosphorylates CREB1" +xref: Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" +xref: Reactome:R-HSA-199839 "AKT can phosphorylate RSK" +xref: Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" +xref: Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" +xref: Reactome:R-HSA-199910 "MSK1 activates ATF1" +xref: Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" +xref: Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" +xref: Reactome:R-HSA-199935 "MSK1 activates CREB" +xref: Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" +xref: Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" +xref: Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" +xref: Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" +xref: Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" +xref: Reactome:R-HSA-202222 "Phosphorylation of PKC theta" +xref: Reactome:R-HSA-202437 "Phosphorylation of CARMA1" +xref: Reactome:R-HSA-202459 "Phosphorylation of Bcl10" +xref: Reactome:R-HSA-202500 "Activation of IKK complex" +xref: Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" +xref: Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" +xref: Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" +xref: Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" +xref: Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" +xref: Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" +xref: Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" +xref: Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" +xref: Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" +xref: Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" +xref: Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" +xref: Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" +xref: Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" +xref: Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" +xref: Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" +xref: Reactome:R-HSA-2029454 "Autophosphorylation of PAK1" +xref: Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" +xref: Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" +xref: Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" +xref: Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" +xref: Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" +xref: Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" +xref: Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" +xref: Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" +xref: Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" +xref: Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" +xref: Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" +xref: Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" +xref: Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" +xref: Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" +xref: Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" +xref: Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" +xref: Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" +xref: Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" +xref: Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" +xref: Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" +xref: Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" +xref: Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" +xref: Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" +xref: Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" +xref: Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" +xref: Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" +xref: Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" +xref: Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" +xref: Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" +xref: Reactome:R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" +xref: Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" +xref: Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" +xref: Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" +xref: Reactome:R-HSA-2730856 "Autophosphorylation of PAK" +xref: Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" +xref: Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" +xref: Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" +xref: Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" +xref: Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" +xref: Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" +xref: Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" +xref: Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" +xref: Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" +xref: Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" +xref: Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" +xref: Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" +xref: Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" +xref: Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" +xref: Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" +xref: Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" +xref: Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" +xref: Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" +xref: Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" +xref: Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" +xref: Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" +xref: Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" +xref: Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" +xref: Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" +xref: Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" +xref: Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" +xref: Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" +xref: Reactome:R-HSA-3769394 "AKT phosphorylates CBY1" +xref: Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" +xref: Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" +xref: Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" +xref: Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" +xref: Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" +xref: Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" +xref: Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" +xref: Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" +xref: Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" +xref: Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" +xref: Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" +xref: Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" +xref: Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" +xref: Reactome:R-HSA-3928620 "PAK1 autophosphorylates" +xref: Reactome:R-HSA-3928625 "PAKs autophosphorylate" +xref: Reactome:R-HSA-3928640 "PAKs phosphorylate MLC" +xref: Reactome:R-HSA-399939 "Autophosphorylation of PAK" +xref: Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" +xref: Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" +xref: Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" +xref: Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" +xref: Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" +xref: Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" +xref: Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" +xref: Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" +xref: Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" +xref: Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" +xref: Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" +xref: Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" +xref: Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" +xref: Reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" +xref: Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" +xref: Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" +xref: Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" +xref: Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" +xref: Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" +xref: Reactome:R-HSA-4411402 "Activation of NLK" +xref: Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" +xref: Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" +xref: Reactome:R-HSA-442832 "PAK phosphorylates cortactin" +xref: Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" +xref: Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" +xref: Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" +xref: Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" +xref: Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" +xref: Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" +xref: Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" +xref: Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" +xref: Reactome:R-HSA-450474 "MK2 phosphorylates BRF1" +xref: Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" +xref: Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" +xref: Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." +xref: Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" +xref: Reactome:R-HSA-451347 "Activation of JNK by DSCAM" +xref: Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" +xref: Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" +xref: Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" +xref: Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" +xref: Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" +xref: Reactome:R-HSA-5213464 "RIPK1 is phosphorylated" +xref: Reactome:R-HSA-5213466 "RIPK3 is phosphorylated" +xref: Reactome:R-HSA-5218814 "PAK2 autophorylates" +xref: Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" +xref: Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" +xref: Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" +xref: Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" +xref: Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" +xref: Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" +xref: Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" +xref: Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" +xref: Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" +xref: Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" +xref: Reactome:R-HSA-5357831 "CYLD is phosphorylated by IKK" +xref: Reactome:R-HSA-5578777 "DMPK phosphorylates PLN" +xref: Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" +xref: Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" +xref: Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" +xref: Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" +xref: Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" +xref: Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" +xref: Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" +xref: Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" +xref: Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" +xref: Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" +xref: Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" +xref: Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" +xref: Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" +xref: Reactome:R-HSA-5635841 "GLI proteins are phosphorylated" +xref: Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" +xref: Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" +xref: Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" +xref: Reactome:R-HSA-5668545 "NIK autophosphorylates on T559" +xref: Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" +xref: Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" +xref: Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" +xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" +xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" +xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" +xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" +xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1" +xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" +xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" +xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" +xref: Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" +xref: Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" +xref: Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" +xref: Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" +xref: Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" +xref: Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" +xref: Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" +xref: Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" +xref: Reactome:R-HSA-5682598 "ATM phosphorylates HERC2" +xref: Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" +xref: Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" +xref: Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" +xref: Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" +xref: Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" +xref: Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" +xref: Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" +xref: Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" +xref: Reactome:R-HSA-5685156 "ATR phosphorylates RPA2" +xref: Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" +xref: Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" +xref: Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" +xref: Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" +xref: Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" +xref: Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" +xref: Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" +xref: Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" +xref: Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" +xref: Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" +xref: Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" +xref: Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" +xref: Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" +xref: Reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" +xref: Reactome:R-HSA-5693536 "ATM phosphorylates MDC1" +xref: Reactome:R-HSA-5693540 "MRN activates ATM" +xref: Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" +xref: Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" +xref: Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" +xref: Reactome:R-HSA-5693598 "ATM phosphorylates NBN" +xref: Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" +xref: Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" +xref: Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" +xref: Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" +xref: Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" +xref: Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" +xref: Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" +xref: Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" +xref: Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" +xref: Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" +xref: Reactome:R-HSA-6799332 "ATR phosphorylates TP53" +xref: Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" +xref: Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" +xref: Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" +xref: Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" +xref: Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" +xref: Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" +xref: Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" +xref: Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" +xref: Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" +xref: Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" +xref: Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" +xref: Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" +xref: Reactome:R-HSA-6804276 "ATM phosphorylates TTC5" +xref: Reactome:R-HSA-6804955 "ATM phosphorylates MDM2" +xref: Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" +xref: Reactome:R-HSA-6805103 "AURKA phosphorylates TP53" +xref: Reactome:R-HSA-6805126 "AURKB phosphorylates TP53" +xref: Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" +xref: Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" +xref: Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" +xref: Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" +xref: Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" +xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20" +xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" +xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" +xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" +xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" +xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" +xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" +xref: Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" +xref: Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" +xref: Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" +xref: Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" +xref: Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" +xref: Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" +xref: Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" +xref: Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" +xref: Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" +xref: Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" +xref: Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" +xref: Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" +xref: Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" +xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" +xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" +xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" +xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" +xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3" +xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" +xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" +xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" +xref: Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" +xref: Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" +xref: Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" +xref: Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" +xref: Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" +xref: Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" +xref: Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" +xref: Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" +xref: Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" +xref: Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" +xref: Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" +xref: Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" +xref: Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" +xref: Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" +xref: Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" +xref: Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" +xref: Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" +xref: Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" +xref: Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" +xref: Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" +xref: Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" +xref: Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" +xref: Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" +xref: Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" +xref: Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" +xref: Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" +xref: Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" +xref: Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" +xref: Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" +xref: Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" +xref: Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" +xref: Reactome:R-HSA-933525 "Phosphorylation and release of IRF7" +xref: Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" +xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" +xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" +xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" +xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" +xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" +xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" +xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF" +xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1" +xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF" +xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" +xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs" +xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" +xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" +xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate" +xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" +xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" +xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" +xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" +xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" +xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates" +xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" +xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA" +xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4" +xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates" +xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" +xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs" +xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181" +xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" +xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer" +xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17" +xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL" +xref: Reactome:R-HSA-9681627 "GSK3 phosphorylates N" +xref: Reactome:R-HSA-9683664 "GSK3B phosphorylates Ncap" +xref: Reactome:R-HSA-9694293 "GSK3B phosphorylates Ncap" +xref: Reactome:R-HSA-9694620 "GSK3 phosphorylates N" +xref: Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3" +xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" +xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" +xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" +xref: Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" +xref: Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" +xref: Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" +xref: Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" +xref: Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88" +xref: Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" +xref: Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004675 +name: transmembrane receptor protein serine/threonine kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30] +synonym: "receptor protein serine/threonine kinase activity" RELATED [EC:2.7.11.30] +synonym: "receptor serine/threonine protein kinase activity" RELATED [EC:2.7.11.30] +xref: EC:2.7.11.30 +xref: MetaCyc:2.7.11.30-RXN +xref: Reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly" +xref: Reactome:R-HSA-198732 "STAT3 activation" +xref: Reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly" +xref: RHEA:18673 +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0004676 +name: 3-phosphoinositide-dependent protein kinase activity +namespace: molecular_function +def: "Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] +comment: This reaction requires the presence of a phosphatidylinositol-3-phosphate. +synonym: "PDK activity" RELATED [PMID:10075713] +synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT [] +xref: Reactome:R-HSA-437195 "PDPK1 activates PRKCZ" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004677 +name: DNA-dependent protein kinase activity +namespace: molecular_function +def: "DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] +comment: This reaction requires the presence of DNA. +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004679 +name: AMP-activated protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah] +synonym: "5'-AMP-activated protein kinase activity" EXACT [] +synonym: "AMPK activity" RELATED [GOC:mah] +synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] +xref: EC:2.7.11.11 +xref: Reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A" +xref: Reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK" +xref: Reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis" +xref: Reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2" +xref: Reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex" +xref: Reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex" +xref: Reactome:R-HSA-6805470 "AMPK phosphorylates TP53" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004680 +name: obsolete casein kinase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "casein kinase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004674 + +[Term] +id: GO:0004681 +name: obsolete casein kinase I activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "casein kinase I activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004674 + +[Term] +id: GO:0004682 +name: obsolete protein kinase CK2 activity +namespace: molecular_function +alt_id: GO:0008604 +def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "casein kinase II activity" RELATED [] +synonym: "casein kinase II, catalytic activity" EXACT [] +synonym: "protein kinase CK2 activity" EXACT [] +synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004674 + +[Term] +id: GO:0004683 +name: calmodulin-dependent protein kinase activity +namespace: molecular_function +alt_id: GO:0004684 +alt_id: GO:0004685 +alt_id: GO:0004688 +def: "Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah, PMID:11264466] +comment: These reactions require the presence of calcium-bound calmodulin. +synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] +synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" RELATED [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase activity" RELATED [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] +synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] +synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] +synonym: "calcium/calmodulin-dependent protein kinase activity" RELATED [EC:2.7.11.17] +synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] +synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] +synonym: "calmodulin regulated protein kinase activity" EXACT [] +synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] +synonym: "calmodulin-dependent protein kinase I activity" NARROW [] +synonym: "CaM kinase activity" RELATED [EC:2.7.11.17] +synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] +synonym: "CAM PKII" RELATED [EC:2.7.11.17] +synonym: "CaM-regulated serine/threonine kinase activity" RELATED [EC:2.7.11.17] +synonym: "CaMKI" RELATED [EC:2.7.11.17] +synonym: "CaMKII" RELATED [EC:2.7.11.17] +synonym: "CaMKIV" RELATED [EC:2.7.11.17] +synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] +synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] +synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] +synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] +synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] +synonym: "STK20" RELATED [EC:2.7.11.17] +xref: EC:2.7.11.17 +xref: MetaCyc:2.7.11.17-RXN +xref: Reactome:R-HSA-111912 "CaMK4 phosphorylates CREB1" +xref: Reactome:R-HSA-111915 "CAMK4 autophosphorylates" +xref: Reactome:R-HSA-416320 "Trafficking of GluR1-containing AMPA receptors" +xref: Reactome:R-HSA-442749 "CaMKK autophosphorylates in the nucleus" +xref: Reactome:R-HSA-9006992 "MECP2 is phosphorylated at S423" +xref: Reactome:R-HSA-9617583 "CaMKII autophosphorylates" +xref: Reactome:R-HSA-9618750 "CaMKII phosphorylates AMPA receptor" +xref: Reactome:R-HSA-9619125 "CaMKK phosphorylates CAMK4" +xref: Reactome:R-HSA-9619355 "CaMKK autophosphorylates in the cytosol" +xref: Reactome:R-HSA-9619367 "CaMKKs phosphorylate CAMK1" +xref: Reactome:R-HSA-9619478 "CAMKK2 phosphorylates AMPK" +xref: Reactome:R-HSA-9619783 "CAMK1 phosphorylates ARHGEF7-1" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004686 +name: elongation factor-2 kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN] +synonym: "ATP:elongation factor 2 phosphotransferase activity" RELATED [EC:2.7.11.20] +synonym: "Ca/CaM-kinase III activity" RELATED [EC:2.7.11.20] +synonym: "calmodulin-dependent protein kinase III activity" RELATED [EC:2.7.11.20] +synonym: "CaM kinase III activity" RELATED [EC:2.7.11.20] +synonym: "eEF-2 kinase activity" EXACT [] +synonym: "eEF2 kinase activity" RELATED [EC:2.7.11.20] +synonym: "eEF2K" RELATED [EC:2.7.11.20] +synonym: "EF2K" RELATED [EC:2.7.11.20] +synonym: "elongation factor 2 kinase activity" RELATED [EC:2.7.11.20] +synonym: "eukaryotic elongation factor 2 kinase activity" RELATED [EC:2.7.11.20] +synonym: "STK19" RELATED [EC:2.7.11.20] +xref: EC:2.7.11.20 +xref: MetaCyc:2.7.11.20-RXN +xref: RHEA:21436 +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0004687 +name: myosin light chain kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] +synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] +synonym: "ATP:myosin-light-chain O-phosphotransferase activity" RELATED [EC:2.7.11.18] +synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" RELATED [EC:2.7.11.18] +synonym: "MLCK" RELATED [EC:2.7.11.18] +synonym: "MLCkase activity" RELATED [EC:2.7.11.18] +synonym: "myosin kinase activity" RELATED [EC:2.7.11.18] +synonym: "myosin light chain protein kinase activity" RELATED [EC:2.7.11.18] +synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] +synonym: "myosin light-chain kinase (phosphorylating)" RELATED [EC:2.7.11.18] +synonym: "myosin light-chain kinase (phosphorylating) activity" RELATED [EC:2.7.11.18] +synonym: "myosin light-chain kinase activity" RELATED [EC:2.7.11.18] +synonym: "myosin-light-chain kinase activity" EXACT [] +synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] +synonym: "STK18" RELATED [EC:2.7.11.18] +xref: EC:2.7.11.18 +xref: MetaCyc:2.7.11.18-RXN +xref: Reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains" +xref: Reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex" +xref: RHEA:22004 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004689 +name: phosphorylase kinase activity +namespace: molecular_function +alt_id: GO:0008606 +def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] +synonym: "ATP:phosphorylase-b phosphotransferase activity" RELATED [EC:2.7.11.19] +synonym: "dephosphophosphorylase kinase activity" RELATED [EC:2.7.11.19] +synonym: "glycogen phosphorylase kinase activity" RELATED [EC:2.7.11.19] +synonym: "PHK" RELATED [EC:2.7.11.19] +synonym: "phosphorylase B kinase activity" RELATED [EC:2.7.11.19] +synonym: "phosphorylase kinase (phosphorylating) activity" RELATED [EC:2.7.11.19] +synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] +synonym: "STK17" RELATED [EC:2.7.11.19] +xref: EC:2.7.11.19 +xref: MetaCyc:2.7.11.19-RXN +xref: Reactome:R-HSA-453337 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP" +xref: Reactome:R-HSA-71541 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP" +xref: Reactome:R-HSA-71588 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP" +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0004690 +name: cyclic nucleotide-dependent protein kinase activity +namespace: molecular_function +def: "cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] +comment: This reaction requires the presence of a cyclic nucleotide. +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004691 +name: cAMP-dependent protein kinase activity +namespace: molecular_function +alt_id: GO:0008602 +def: "cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [EC:2.7.11.11] +comment: This reaction requires the presence of cAMP. +synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] +synonym: "AMPK" RELATED [EC:2.7.11.11] +synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" RELATED [EC:2.7.11.11] +synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] +synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] +synonym: "PKA" RELATED [EC:2.7.11.11] +synonym: "PKA C" RELATED [EC:2.7.11.11] +synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] +synonym: "STK22" RELATED [EC:2.7.11.11] +xref: EC:2.7.11.11 +xref: MetaCyc:2.7.11.11-RXN +xref: Reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(666) by PKA" +xref: Reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA" +xref: Reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit" +xref: Reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34" +xref: Reactome:R-HSA-177284 "PKA phosphorylates PDE4B" +xref: Reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)" +xref: Reactome:R-HSA-5610717 "PKA phosphorylates GLI2" +xref: Reactome:R-HSA-5610720 "PKA phosphorylates GLI3" +xref: Reactome:R-HSA-5610741 "PKA phosphorylates GLI1" +xref: Reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3" +xref: Reactome:R-HSA-5617182 "PRKACA phosphorylates PLN" +xref: Reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5" +xref: Reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585" +is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity + +[Term] +id: GO:0004692 +name: cGMP-dependent protein kinase activity +namespace: molecular_function +def: "cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:mah] +comment: This reaction requires the presence of cGMP. +synonym: "3':5'-cyclic GMP-dependent protein kinase activity" RELATED [EC:2.7.11.12] +synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" RELATED [EC:2.7.11.12] +synonym: "cGMP-dependent protein kinase ibeta activity" RELATED [EC:2.7.11.12] +synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" RELATED [EC:2.7.11.12] +synonym: "PKG" RELATED [EC:2.7.11.12] +synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] +synonym: "PKG 1beta" RELATED [EC:2.7.11.12] +synonym: "PKG II" RELATED [EC:2.7.11.12] +synonym: "STK23" RELATED [EC:2.7.11.12] +xref: EC:2.7.11.12 +xref: MetaCyc:2.7.11.12-RXN +xref: Reactome:R-HSA-1475422 "PTPS is phosphorylated by cGMP-dependant protein kinase II" +xref: Reactome:R-HSA-1497853 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II" +xref: Reactome:R-HSA-418442 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release" +xref: Reactome:R-HSA-418549 "PKG1 phosphorylates BK channels" +is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity + +[Term] +id: GO:0004693 +name: cyclin-dependent protein serine/threonine kinase activity +namespace: molecular_function +alt_id: GO:0016537 +def: "Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] +comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). +synonym: "ATP:cyclin phosphotransferase activity" RELATED [EC:2.7.11.22] +synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] +synonym: "CDK" RELATED [EC:2.7.11.22] +synonym: "CDK activity" EXACT [] +synonym: "CDK, catalytic subunit activity" EXACT [] +synonym: "cdk-activating kinase activity" RELATED [EC:2.7.11.22] +synonym: "Cdk-activating protein kinase activity" RELATED [EC:2.7.11.22] +synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] +synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] +synonym: "cyclin-dependent protein kinase activity" BROAD [] +synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] +synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] +synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] +xref: EC:2.7.11.22 +xref: MetaCyc:2.7.11.22-RXN +xref: Reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex" +xref: Reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex" +xref: Reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" +xref: Reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2" +xref: Reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2" +xref: Reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" +xref: Reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75" +xref: Reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21" +xref: Reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21" +xref: Reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2" +xref: Reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)" +xref: Reactome:R-HSA-188390 "Cyclin E:CDK2-mediated phosphorylation of RB1" +xref: Reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8" +xref: Reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB" +xref: Reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants" +xref: Reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8" +xref: Reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3" +xref: Reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL" +xref: Reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres" +xref: Reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms" +xref: Reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I" +xref: Reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9" +xref: Reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98" +xref: Reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2" +xref: Reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1" +xref: Reactome:R-HSA-4086410 "CDK1 phosphorylates BORA" +xref: Reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1" +xref: Reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN" +xref: Reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments" +xref: Reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6" +xref: Reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218" +xref: Reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes" +xref: Reactome:R-HSA-6805109 "CDK2 phosphorylates TP53" +xref: Reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2" +xref: Reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK" +xref: Reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes" +xref: Reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes" +xref: Reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes" +xref: Reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2" +xref: Reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2" +xref: Reactome:R-HSA-9624800 "CDK1 phosphorylates LBR" +xref: Reactome:R-HSA-9686521 "CDK2:CCNA phosphorylates TERF2" +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0097472 ! cyclin-dependent protein kinase activity + +[Term] +id: GO:0004694 +name: eukaryotic translation initiation factor 2alpha kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516] +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0004697 +name: protein kinase C activity +namespace: molecular_function +alt_id: GO:0004701 +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] +synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" RELATED [EC:2.7.11.13] +synonym: "cPKC" RELATED [EC:2.7.11.13] +synonym: "cPKCalpha" RELATED [EC:2.7.11.13] +synonym: "cPKCbeta" RELATED [EC:2.7.11.13] +synonym: "cPKCgamma" RELATED [EC:2.7.11.13] +synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] +synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] +synonym: "nPKC" RELATED [EC:2.7.11.13] +synonym: "nPKCdelta" RELATED [EC:2.7.11.13] +synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] +synonym: "nPKCeta" RELATED [EC:2.7.11.13] +synonym: "nPKCtheta" RELATED [EC:2.7.11.13] +synonym: "PKC" RELATED [EC:2.7.11.13] +synonym: "PKC activity" EXACT [] +synonym: "Pkc1p" RELATED [EC:2.7.11.13] +synonym: "PKCalpha" RELATED [EC:2.7.11.13] +synonym: "PKCbeta" RELATED [EC:2.7.11.13] +synonym: "PKCdelta" RELATED [EC:2.7.11.13] +synonym: "PKCepsilon" RELATED [EC:2.7.11.13] +synonym: "PKCgamma" RELATED [EC:2.7.11.13] +synonym: "PKCzeta" RELATED [EC:2.7.11.13] +synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] +synonym: "STK24" RELATED [EC:2.7.11.13] +xref: EC:2.7.11.13 +xref: MetaCyc:2.7.11.13-RXN +xref: Reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT" +xref: Reactome:R-HSA-193703 "IKKbeta is activated" +xref: Reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta" +xref: Reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3" +xref: Reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta" +xref: Reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin" +xref: Reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates COL4A3BP-2" +xref: Reactome:R-HSA-450533 "PKCdelta phosphorylates HuR" +xref: Reactome:R-HSA-450550 "PKCalpha phosphorylates HuR" +xref: Reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC" +xref: Reactome:R-HSA-5218805 "PKC autophosphorylates" +xref: Reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1" +xref: Reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation" +xref: Reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3" +xref: Reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters" +xref: Reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C" +xref: Reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP" +xref: Reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)" +xref: Reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1" +xref: Reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1" +xref: Reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3" +xref: Reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727" +xref: Reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)" +xref: Reactome:R-HSA-9626817 "PKC phosphorylates NCF1" +xref: Reactome:R-HSA-9632858 "PRKCZ autophosphorylates downstream of estrogen stimulation" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004698 +name: calcium-dependent protein kinase C activity +namespace: molecular_function +def: "Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [EC:2.7.11.13, GOC:mah] +comment: This reaction requires diacylglycerol and calcium. +synonym: "calcium-dependent PKC activity" EXACT [] +synonym: "conventional protein kinase C activity" EXACT [PMID:9601053] +xref: EC:2.7.11.13 +xref: Reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1" +xref: Reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4" +xref: Reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites" +xref: Reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors" +is_a: GO:0004697 ! protein kinase C activity +is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity + +[Term] +id: GO:0004699 +name: calcium-independent protein kinase C activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] +synonym: "calcium-independent PKC activity" EXACT [] +synonym: "novel protein kinase C activity" EXACT [PMID:9601053] +xref: Reactome:R-HSA-5607740 "PKC-delta phosphorylates CARD9" +is_a: GO:0004697 ! protein kinase C activity + +[Term] +id: GO:0004702 +name: obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity +namespace: molecular_function +def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] +comment: This term was obsoleted because it was not clearly defined. +synonym: "receptor signaling protein serine/threonine kinase activity" EXACT [] +synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] +xref: EC:2.7.11.- +is_obsolete: true + +[Term] +id: GO:0004703 +name: G protein-coupled receptor kinase activity +namespace: molecular_function +alt_id: GO:0004678 +def: "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate." [GOC:dph] +synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" RELATED [EC:2.7.11.16] +synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] +synonym: "G-protein coupled receptor kinase activity" RELATED [EC:2.7.11.16] +synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] +synonym: "GPCR kinase activity" RELATED [EC:2.7.11.16] +synonym: "GPCR phosphorylating protein kinase activity" EXACT [] +synonym: "GPCRK" RELATED [EC:2.7.11.16] +synonym: "GRK4" RELATED [EC:2.7.11.16] +synonym: "GRK5" RELATED [EC:2.7.11.16] +synonym: "GRK6" RELATED [EC:2.7.11.16] +synonym: "STK16" RELATED [EC:2.7.11.16] +xref: EC:2.7.11.16 +xref: RHEA:12008 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004704 +name: NF-kappaB-inducing kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151] +synonym: "NIK" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0004705 +name: JUN kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732] +synonym: "c-Jun N-terminal kinase activity" NARROW [] +synonym: "JNK" EXACT [] +synonym: "JNK3alpha1" RELATED [] +synonym: "SAPK1" NARROW [] +xref: Reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN" +xref: Reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK" +xref: Reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets" +xref: Reactome:R-HSA-205132 "NRAGE activates JNK" +xref: Reactome:R-HSA-9673789 "Activated JNK phosphorylates c-JUN" +is_a: GO:0004707 ! MAP kinase activity + +[Term] +id: GO:0004706 +name: JUN kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] +synonym: "JNK kinase kinase activity" RELATED [] +synonym: "JNKKK" EXACT [] +is_a: GO:0004709 ! MAP kinase kinase kinase activity + +[Term] +id: GO:0004707 +name: MAP kinase activity +namespace: molecular_function +alt_id: GO:0008338 +alt_id: GO:0008339 +alt_id: GO:0016908 +alt_id: GO:0016909 +def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] +synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" RELATED [EC:2.7.11.24] +synonym: "ERK" RELATED [EC:2.7.11.24] +synonym: "ERK1" EXACT [] +synonym: "ERK2" RELATED [] +synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] +synonym: "MAP kinase 1 activity" NARROW [] +synonym: "MAP kinase 2 activity" NARROW [] +synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974] +synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] +synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] +synonym: "mitogen activated kinase activity" EXACT [] +synonym: "mitogen-activated protein kinase activity" RELATED [EC:2.7.11.24] +synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] +synonym: "SAP kinase activity" NARROW [] +synonym: "SAPK" NARROW [] +synonym: "stress-activated kinase activity" NARROW [] +synonym: "stress-activated protein kinase activity" NARROW [] +xref: EC:2.7.11.24 +xref: KEGG_REACTION:R00162 +xref: MetaCyc:2.7.11.24-RXN +xref: Reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2" +xref: Reactome:R-HSA-198733 "ERK5 is activated" +xref: Reactome:R-HSA-445079 "Phosphorylation of L1 by ERK" +xref: Reactome:R-HSA-451366 "Activation of p38MAPK by DSCAM" +xref: Reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2." +xref: Reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2" +xref: Reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2." +xref: Reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2." +xref: Reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter" +xref: Reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004708 +name: MAP kinase kinase activity +namespace: molecular_function +def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684] +synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" RELATED [EC:2.7.12.2] +synonym: "ERK activator kinase activity" EXACT [] +synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] +synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] +synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] +synonym: "MAP2K" RELATED [EC:2.7.12.2] +synonym: "MAPK activator activity" EXACT [GOC:vw] +synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974] +synonym: "MAPKK activity" EXACT [] +synonym: "MAPKK1" RELATED [EC:2.7.12.2] +synonym: "MEK activity" BROAD [] +synonym: "MEK1" RELATED [EC:2.7.12.2] +synonym: "MEK2" RELATED [EC:2.7.12.2] +synonym: "mitogen-activated protein kinase kinase activity" RELATED [EC:2.7.12.2] +synonym: "MKK" RELATED [EC:2.7.12.2] +synonym: "MKK2" RELATED [EC:2.7.12.2] +synonym: "MKK4" RELATED [EC:2.7.12.2] +synonym: "MKK6" RELATED [EC:2.7.12.2] +synonym: "MKK7" RELATED [EC:2.7.12.2] +synonym: "STK27" RELATED [EC:2.7.12.2] +xref: EC:2.7.12.2 +xref: MetaCyc:2.7.12.2-RXN +xref: Reactome:R-HSA-1247960 "Activation of p38 MAPK" +xref: Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5" +xref: Reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK" +xref: Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3" +xref: Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR" +is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity + +[Term] +id: GO:0004709 +name: MAP kinase kinase kinase activity +namespace: molecular_function +alt_id: GO:0004710 +def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] +synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" RELATED [EC:2.7.11.25] +synonym: "cMos" RELATED [EC:2.7.11.25] +synonym: "cRaf" RELATED [EC:2.7.11.25] +synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974] +synonym: "MAPK/ERK kinase kinase activity" EXACT [] +synonym: "MAPKKK activity" RELATED [EC:2.7.11.25] +synonym: "MEK kinase activity" RELATED [EC:2.7.11.25] +synonym: "MEKK" RELATED [EC:2.7.11.25] +synonym: "MEKK activity" EXACT [] +synonym: "MEKK1" RELATED [EC:2.7.11.25] +synonym: "MEKK2" RELATED [EC:2.7.11.25] +synonym: "MEKK3" RELATED [EC:2.7.11.25] +synonym: "Mil/Raf" RELATED [EC:2.7.11.25] +synonym: "mitogen-activated protein kinase kinase kinase activity" RELATED [EC:2.7.11.25] +synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] +synonym: "MLTK" RELATED [EC:2.7.11.25] +synonym: "MLTKa" RELATED [EC:2.7.11.25] +synonym: "MLTKb" RELATED [EC:2.7.11.25] +synonym: "REKS" RELATED [EC:2.7.11.25] +synonym: "STK28" RELATED [EC:2.7.11.25] +xref: EC:2.7.11.25 +xref: MetaCyc:2.7.11.25-RXN +xref: Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex" +xref: Reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1" +xref: Reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK" +xref: Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7" +xref: Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6" +xref: Reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1" +xref: Reactome:R-HSA-727819 "TAK1 phosphorylates MKK6" +xref: Reactome:R-HSA-933530 "Activation of IKK by MEKK1" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004711 +name: ribosomal protein S6 kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0004712 +name: protein serine/threonine/tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] +synonym: "dual-specificity kinase activity" EXACT [EC:2.7.12.1] +synonym: "dual-specificity protein kinase" EXACT [] +synonym: "protein threonine/tyrosine kinase activity" NARROW [] +xref: EC:2.7.12.1 +xref: Reactome:R-HSA-5672969 "Phosphorylation of RAF" +xref: Reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane" +xref: Reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants" +xref: Reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants" +xref: Reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants" +xref: Reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants" +xref: Reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS" +xref: Reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS" +xref: Reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated" +xref: Reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF" +xref: Reactome:R-HSA-9656212 "Phosphorylation of RAF1 mutants" +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004713 +name: protein tyrosine kinase activity +namespace: molecular_function +alt_id: GO:0004718 +def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [RHEA:10596] +synonym: "protein-tyrosine kinase activity" EXACT [] +xref: Reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1" +xref: Reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma" +xref: Reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation" +xref: Reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers" +xref: Reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" +xref: Reactome:R-HSA-1248694 "Trans-autophosphorylation of ERBB2 homodimer" +xref: Reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" +xref: Reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" +xref: Reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" +xref: Reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2" +xref: Reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5" +xref: Reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227" +xref: Reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4" +xref: Reactome:R-HSA-1433418 "Phosphorylation of JAK2" +xref: Reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs" +xref: Reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" +xref: Reactome:R-HSA-1433506 "Phosphorylation of APS" +xref: Reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" +xref: Reactome:R-HSA-1470009 "Phosphorylation of STATs" +xref: Reactome:R-HSA-1472121 "Phosphorylation of p-KIT on Y900 by Src kinases" +xref: Reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" +xref: Reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" +xref: Reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" +xref: Reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes" +xref: Reactome:R-HSA-170991 "SRC-1 autophosphorylates" +xref: Reactome:R-HSA-171011 "Binding and activation of MAP Kinase" +xref: Reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15" +xref: Reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" +xref: Reactome:R-HSA-177934 "EGFR autophosphorylation" +xref: Reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase" +xref: Reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)" +xref: Reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)" +xref: Reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers" +xref: Reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1" +xref: Reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1" +xref: Reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2" +xref: Reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions" +xref: Reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors" +xref: Reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3" +xref: Reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4" +xref: Reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b" +xref: Reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c" +xref: Reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b" +xref: Reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c" +xref: Reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b" +xref: Reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c" +xref: Reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c" +xref: Reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src" +xref: Reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers" +xref: Reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers" +xref: Reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2" +xref: Reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1" +xref: Reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant" +xref: Reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants" +xref: Reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant" +xref: Reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes" +xref: Reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck" +xref: Reactome:R-HSA-202174 "Activation of ZAP-70" +xref: Reactome:R-HSA-202216 "Phosphorylation of SLP-76" +xref: Reactome:R-HSA-202233 "Inactivation of Lck by Csk" +xref: Reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT" +xref: Reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1" +xref: Reactome:R-HSA-202291 "Activation of Lck" +xref: Reactome:R-HSA-202307 "Change of PKC theta conformation" +xref: Reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers" +xref: Reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG" +xref: Reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases" +xref: Reactome:R-HSA-2029453 "Phosphorylation of VAV" +xref: Reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts" +xref: Reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants" +xref: Reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants" +xref: Reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding" +xref: Reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding" +xref: Reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity" +xref: Reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants" +xref: Reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity" +xref: Reactome:R-HSA-205289 "Autophosphorylation of KIT" +xref: Reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" +xref: Reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" +xref: Reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" +xref: Reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" +xref: Reactome:R-HSA-2197698 "Src phosphorylate WASP,N-WASP" +xref: Reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" +xref: Reactome:R-HSA-2395412 "Phosphorylation of SYK" +xref: Reactome:R-HSA-2395439 "Phosphorylation of DAP12" +xref: Reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK" +xref: Reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK" +xref: Reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1" +xref: Reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates" +xref: Reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK" +xref: Reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK" +xref: Reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK" +xref: Reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4" +xref: Reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN" +xref: Reactome:R-HSA-2454239 "Phosphorylation of SYK" +xref: Reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR" +xref: Reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin" +xref: Reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin" +xref: Reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin" +xref: Reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin" +xref: Reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK" +xref: Reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK" +xref: Reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK" +xref: Reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK" +xref: Reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN" +xref: Reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase" +xref: Reactome:R-HSA-2730882 "Phosphorylation of PKC-theta" +xref: Reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn" +xref: Reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase" +xref: Reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma" +xref: Reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F" +xref: Reactome:R-HSA-354073 "Autophosphorylation of PTK2 at Y397" +xref: Reactome:R-HSA-354124 "Phosphorylation of pPTK2 by SRC" +xref: Reactome:R-HSA-372693 "Phosphorylation of BCAR1 by SRC-PTK2 complex" +xref: Reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN" +xref: Reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2" +xref: Reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn" +xref: Reactome:R-HSA-377640 "Autophosphorylation of SRC" +xref: Reactome:R-HSA-380780 "Activation of Src" +xref: Reactome:R-HSA-388831 "Phosphorylation of CD28" +xref: Reactome:R-HSA-388833 "Phosphorylation of CTLA-4" +xref: Reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors" +xref: Reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors" +xref: Reactome:R-HSA-389354 "Activation of Vav1" +xref: Reactome:R-HSA-389762 "Phosphorylation of PD-1" +xref: Reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha" +xref: Reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts" +xref: Reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase" +xref: Reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn" +xref: Reactome:R-HSA-3928578 "EPH receptors autophosphorylate" +xref: Reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs" +xref: Reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B" +xref: Reactome:R-HSA-3928594 "SFKs phosphorylate GIT1" +xref: Reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3" +xref: Reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397" +xref: Reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1" +xref: Reactome:R-HSA-3928648 "SFKs phosphorylate NGEF" +xref: Reactome:R-HSA-399934 "Phosphorylation of Plexin-A" +xref: Reactome:R-HSA-399946 "Recruitment and activation of Cdk5" +xref: Reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes" +xref: Reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2" +xref: Reactome:R-HSA-418163 "Activated Src activates ERK" +xref: Reactome:R-HSA-418859 "Phosphorylation of Unc5C" +xref: Reactome:R-HSA-418872 "Phosphorylation of FADK1" +xref: Reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met" +xref: Reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase" +xref: Reactome:R-HSA-429441 "SYK activation by SRC" +xref: Reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation" +xref: Reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8" +xref: Reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT" +xref: Reactome:R-HSA-4420117 "VEGFR2 autophosphorylates" +xref: Reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1" +xref: Reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB" +xref: Reactome:R-HSA-4420206 "Phosphorylation of SRC-1" +xref: Reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2" +xref: Reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1" +xref: Reactome:R-HSA-445084 "Phosphorylation of L1 by SRC" +xref: Reactome:R-HSA-445085 "Phosphorylation of VAV2" +xref: Reactome:R-HSA-445091 "Phosphorylation of Neurofascin" +xref: Reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1" +xref: Reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated" +xref: Reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated" +xref: Reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB" +xref: Reactome:R-HSA-508282 "SYK is a substrate for JAK1" +xref: Reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2" +xref: Reactome:R-HSA-5218642 "PTK2 autophosphorylates" +xref: Reactome:R-HSA-5218806 "FYN autophosphorylates" +xref: Reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118" +xref: Reactome:R-HSA-5218812 "FYN phosphorylates PAK2" +xref: Reactome:R-HSA-5218820 "Src kinases phosphorylate VAV" +xref: Reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1" +xref: Reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta" +xref: Reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407" +xref: Reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814" +xref: Reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG" +xref: Reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan" +xref: Reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG" +xref: Reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2" +xref: Reactome:R-HSA-5621370 "SYK autophosphorylates" +xref: Reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341" +xref: Reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant" +xref: Reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII" +xref: Reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1" +xref: Reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2" +xref: Reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1" +xref: Reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2" +xref: Reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2" +xref: Reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1" +xref: Reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c" +xref: Reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2" +xref: Reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3" +xref: Reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1" +xref: Reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11" +xref: Reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3" +xref: Reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11" +xref: Reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3" +xref: Reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11" +xref: Reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1" +xref: Reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3" +xref: Reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11" +xref: Reactome:R-HSA-5655243 "Activated FGFR3 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655270 "Activated FGFR3 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2" +xref: Reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1" +xref: Reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142" +xref: Reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52" +xref: Reactome:R-HSA-5690702 "LYN phosphorylates CD22" +xref: Reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2" +xref: Reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2" +xref: Reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation" +xref: Reactome:R-HSA-6806974 "MET dimers autophosphorylate" +xref: Reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK" +xref: Reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1" +xref: Reactome:R-HSA-873918 "Transphosphorylation of JAK1" +xref: Reactome:R-HSA-873919 "Phosphorylation of JAK2" +xref: Reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases" +xref: Reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases" +xref: Reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor" +xref: Reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2" +xref: Reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated" +xref: Reactome:R-HSA-8847977 "FRK phosphorylates PTEN" +xref: Reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation" +xref: Reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2" +xref: Reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3" +xref: Reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B" +xref: Reactome:R-HSA-8848606 "PTK6 phosphorylates PXN" +xref: Reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1" +xref: Reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1" +xref: Reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1" +xref: Reactome:R-HSA-8848818 "PTK6 phosphorylates CBL" +xref: Reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1" +xref: Reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1" +xref: Reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2" +xref: Reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3" +xref: Reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35" +xref: Reactome:R-HSA-8849102 "SRMS phosphorylates PTK6" +xref: Reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ" +xref: Reactome:R-HSA-8851890 "MET phosphorylates SHC1-2" +xref: Reactome:R-HSA-8851933 "MET phosphorylates GAB1" +xref: Reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions" +xref: Reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate" +xref: Reactome:R-HSA-8853315 "Activated FGFR3 fusions phosphorylate FRS2" +xref: Reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate" +xref: Reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1" +xref: Reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB" +xref: Reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation" +xref: Reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6" +xref: Reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307" +xref: Reactome:R-HSA-8867041 "EGFR phosphorylates EPS15" +xref: Reactome:R-HSA-8874078 "PTK2 autophosphorylates" +xref: Reactome:R-HSA-8874080 "SRC phosphorylates PTK2" +xref: Reactome:R-HSA-8874082 "MET phosphorylates PTK2" +xref: Reactome:R-HSA-8875451 "MET phosphorylates CBL" +xref: Reactome:R-HSA-8875817 "MET phosphorylates STAT3" +xref: Reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates" +xref: Reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL" +xref: Reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1" +xref: Reactome:R-HSA-8937728 "SRC phosphorylates RUNX1" +xref: Reactome:R-HSA-8937807 "SRC phosphorylates RUNX3" +xref: Reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1" +xref: Reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes" +xref: Reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18" +xref: Reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1" +xref: Reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC" +xref: Reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC" +xref: Reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4" +xref: Reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR" +xref: Reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin" +xref: Reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1" +xref: Reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2" +xref: Reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3" +xref: Reactome:R-HSA-9021609 "ESR-associated SRC autophosphorylates" +xref: Reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1" +xref: Reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1" +xref: Reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1" +xref: Reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2" +xref: Reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1" +xref: Reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2" +xref: Reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2" +xref: Reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1" +xref: Reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1" +xref: Reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3" +xref: Reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates" +xref: Reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B" +xref: Reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5" +xref: Reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation" +xref: Reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate" +xref: Reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1" +xref: Reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1" +xref: Reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2" +xref: Reactome:R-HSA-909718 "Formation of p-STAT1 homodimer" +xref: Reactome:R-HSA-909726 "Phosphorylation of STAT1" +xref: Reactome:R-HSA-909729 "Activation of JAK kinases" +xref: Reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" +xref: Reactome:R-HSA-909732 "Phosphorylation of STAT2" +xref: Reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" +xref: Reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" +xref: Reactome:R-HSA-9604767 "FLT3LG dimer:FLT3 dimer autophosphorylates" +xref: Reactome:R-HSA-9606159 "BTK autophosphorylates" +xref: Reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" +xref: Reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" +xref: Reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs" +xref: Reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" +xref: Reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" +xref: Reactome:R-HSA-9625487 "PTK2 autophosphorylates downstream of EGFR" +xref: Reactome:R-HSA-9634390 "ERBB2 homodimer phosphorylates SHC1" +xref: Reactome:R-HSA-9664261 "Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK" +xref: Reactome:R-HSA-9664275 "Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers" +xref: Reactome:R-HSA-9664278 "Phosphorylation and activation of PLCG due to FCGR3A effect" +xref: Reactome:R-HSA-9664588 "ERBB2 KD mutants trans-autophosphorylate" +xref: Reactome:R-HSA-9664976 "Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665032 "Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665389 "Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate" +xref: Reactome:R-HSA-9665411 "Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665704 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1" +xref: Reactome:R-HSA-9665705 "Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1" +xref: Reactome:R-HSA-9665709 "ERBB2 TMD/JMD heterodimers trans-autophosphorylate" +xref: Reactome:R-HSA-9666425 "p-6Y-SYK phosphorylates VAV1,2,3" +xref: Reactome:R-HSA-9669890 "Constitutive phosphorylation of kinase domain KIT mutants" +xref: Reactome:R-HSA-9669911 "Phosphorylation of juxtamembrane domain KIT mutants" +xref: Reactome:R-HSA-9670412 "Phosphorylation of STATs downstream of KIT mutants" +xref: Reactome:R-HSA-9670418 "Phosphorylation of JAK2 downstream of KIT mutants" +xref: Reactome:R-HSA-9672173 "Autophosphorylation of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672175 "Autophosphorylation of PDGFR mutant dimers" +xref: Reactome:R-HSA-9673756 "Autophosphorylation of cytosolic PDGFRA and PDGFRB fusion proteins" +xref: Reactome:R-HSA-9673761 "Autophosphorylation of membrane-tethered fusions of PDGFRA or PDGFRB" +xref: Reactome:R-HSA-9680248 "Phosphorylation of extracellular domain KIT mutants" +xref: Reactome:R-HSA-9695834 "Constitutive phosphorylation of FLT3 mutants" +xref: Reactome:R-HSA-9698003 "FLT3 mutants phosphorylate GAB2" +xref: Reactome:R-HSA-9698005 "FLT3 ITD mutants phosphorylate STAT5" +xref: Reactome:R-HSA-9699578 "Active FLT3 phosphorylates CDKN1B" +xref: Reactome:R-HSA-9703437 "FLT3 fusion dimers autophosphorylate" +xref: Reactome:R-HSA-9703438 "FLT3 fusions phosphorylate GAB2" +xref: Reactome:R-HSA-9706344 "FLT3 phosphorylates GRB10" +xref: Reactome:R-HSA-9706350 "FLT3 phosphorylates CBL" +xref: Reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" +xref: Reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" +xref: Reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" +xref: Reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)" +xref: RHEA:10596 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004714 +name: transmembrane receptor protein tyrosine kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] +synonym: "receptor protein tyrosine kinase activity" RELATED [EC:2.7.10.1] +synonym: "receptor protein-tyrosine kinase activity" RELATED [EC:2.7.10.1] +xref: EC:2.7.10.1 +xref: MetaCyc:2.7.10.1-RXN +xref: Reactome:R-HSA-166544 "TrkA receptor autophosphorylates" +xref: Reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" +xref: Reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" +xref: Reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" +xref: Reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" +xref: Reactome:R-HSA-198295 "TRKA phosphorylates IRS" +xref: Reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" +xref: Reactome:R-HSA-74711 "Phosphorylation of IRS" +xref: Reactome:R-HSA-74715 "Autophosphorylation of insulin receptor" +xref: Reactome:R-HSA-74742 "Phosphorylation of SHC1" +xref: Reactome:R-HSA-8852552 "MST1R autophosphorylates" +xref: Reactome:R-HSA-8853792 "RET tyrosine phosphorylation" +xref: Reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" +xref: Reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" +xref: Reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" +xref: Reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" +xref: Reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" +xref: Reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" +xref: Reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" +xref: Reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" +xref: Reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" +xref: Reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" +xref: Reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" +xref: Reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" +xref: Reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" +xref: Reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" +xref: Reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" +xref: Reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" +xref: Reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" +xref: Reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" +xref: Reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" +xref: Reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" +xref: Reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" +xref: Reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" +xref: Reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" +xref: Reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" +xref: Reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" +xref: Reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" +xref: Reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" +xref: Reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" +is_a: GO:0004713 ! protein tyrosine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0004715 +name: non-membrane spanning protein tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2] +synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" RELATED [EC:2.7.10.2] +synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] +synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] +synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] +synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] +synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] +synonym: "non-specific protein-tyrosine kinase activity" RELATED [EC:2.7.10.2] +synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] +xref: EC:2.7.10.2 +xref: MetaCyc:2.7.10.2-RXN +xref: Reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor" +xref: Reactome:R-HSA-1112703 "PTPN11 is phosphorylated" +xref: Reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2" +xref: Reactome:R-HSA-1168459 "Lyn activates ERK" +xref: Reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3" +xref: Reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499" +xref: Reactome:R-HSA-1369115 "SHP2 is phosphorylated" +xref: Reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK" +xref: Reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family" +xref: Reactome:R-HSA-453200 "SYK autophosphorylates" +xref: Reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6" +xref: Reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated" +xref: Reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation" +xref: Reactome:R-HSA-879910 "JAK2 is phosphorylated, activated" +xref: Reactome:R-HSA-8871373 "BMX phosphorylates RUFY1" +is_a: GO:0004713 ! protein tyrosine kinase activity + +[Term] +id: GO:0004716 +name: obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity +namespace: molecular_function +def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] +comment: This term was obsoleted because it was not clearly defined. +synonym: "receptor signaling protein tyrosine kinase activity" EXACT [] +synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] +xref: EC:2.7.10.- +is_obsolete: true + +[Term] +id: GO:0004717 +name: obsolete focal adhesion kinase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] +comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. +synonym: "FAK" EXACT [] +synonym: "focal adhesion kinase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004713 + +[Term] +id: GO:0004719 +name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] +synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein (D-aspartate) methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein beta-aspartate O-methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein D-aspartate methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein L-isoaspartate methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein L-isoaspartyl methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein O-methyltransferase (L-isoaspartate)" RELATED [EC:2.1.1.77] +synonym: "protein-beta-aspartate O-methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein-L-isoaspartate O-methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" RELATED [EC:2.1.1.77] +synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" RELATED [EC:2.1.1.77] +xref: EC:2.1.1.77 +xref: MetaCyc:2.1.1.77-RXN +xref: Reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp" +xref: RHEA:12705 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity + +[Term] +id: GO:0004720 +name: protein-lysine 6-oxidase activity +namespace: molecular_function +alt_id: GO:0018056 +def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13] +synonym: "lysyl oxidase activity" RELATED [EC:1.4.3.13] +synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" RELATED [EC:1.4.3.13] +xref: EC:1.4.3.13 +xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN +xref: Reactome:R-HSA-2002466 "Formation of allysine by LOX" +xref: Reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase" +xref: Reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX" +xref: RHEA:24544 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004721 +name: phosphoprotein phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [ISBN:0198547684] +synonym: "phosphoprotein phosphohydrolase activity" EXACT [] +synonym: "protein phosphatase activity" EXACT [] +synonym: "protein phosphatase-1 activity" NARROW [] +synonym: "protein phosphatase-2A activity" NARROW [] +synonym: "protein phosphatase-2B activity" NARROW [] +synonym: "protein phosphatase-2C activity" NARROW [] +xref: MetaCyc:3.1.3.16-RXN +xref: Reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" +xref: Reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin" +xref: Reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A" +xref: Reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A" +xref: Reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" +xref: Reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases" +xref: Reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes" +xref: Reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B" +xref: Reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2" +xref: Reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1" +xref: Reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1" +xref: Reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I" +xref: Reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A" +xref: Reactome:R-HSA-9636684 "ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP" +is_a: GO:0016791 ! phosphatase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004722 +name: protein serine/threonine phosphatase activity +namespace: molecular_function +alt_id: GO:0000158 +alt_id: GO:0000163 +alt_id: GO:0004724 +alt_id: GO:0008598 +alt_id: GO:0008600 +alt_id: GO:0015071 +alt_id: GO:0030357 +alt_id: GO:0030358 +alt_id: GO:0030360 +alt_id: GO:0030361 +alt_id: GO:0106306 +alt_id: GO:0106307 +def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] +synonym: "magnesium-dependent protein serine/threonine phosphatase activity" RELATED [] +synonym: "phosphatase I" NARROW [] +synonym: "phosphatase II" NARROW [] +synonym: "phosphatase III" NARROW [] +synonym: "protein phosphatase type 1 activity" NARROW [] +synonym: "protein phosphatase type 2A activity" NARROW [] +synonym: "protein phosphatase type 2B activity" NARROW [] +synonym: "protein phosphatase type 2C activity" NARROW [] +synonym: "protein phosphatase-1" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2A" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2B" NARROW [EC:3.1.3.16] +synonym: "protein phosphatase-2C" NARROW [EC:3.1.3.16] +synonym: "protein serine phosphatase activity" NARROW [] +synonym: "protein threonine phosphatase activity" NARROW [] +synonym: "serine/threonine specific protein phosphatase activity" EXACT [] +xref: EC:3.1.3.16 +xref: Reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2" +xref: Reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate" +xref: Reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin" +xref: Reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT" +xref: Reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A" +xref: Reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34" +xref: Reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A" +xref: Reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3" +xref: Reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3" +xref: Reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1" +xref: Reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1" +xref: Reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex" +xref: Reactome:R-HSA-380949 "AMPK is dephosphorylated" +xref: Reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1" +xref: Reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate" +xref: Reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN" +xref: Reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1" +xref: Reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs" +xref: Reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1" +xref: Reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338" +xref: Reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P" +xref: Reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1" +xref: Reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2" +xref: Reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6" +xref: Reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH" +xref: Reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24" +xref: Reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2" +xref: Reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma" +xref: Reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO" +xref: Reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5" +xref: Reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4" +xref: Reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII" +xref: Reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1" +xref: Reactome:R-HSA-9658445 "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs" +xref: Reactome:R-HSA-9660536 "SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex" +xref: Reactome:R-HSA-9660538 "Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs" +xref: Reactome:R-HSA-9686524 "PP6-PPP6R3 dephosphorylates TERF2" +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0004723 +name: calcium-dependent protein serine/threonine phosphatase activity +namespace: molecular_function +alt_id: GO:0008596 +def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah] +synonym: "calcineurin" NARROW [] +synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] +xref: Reactome:R-HSA-2025882 "Calcineurin dephosphorylates NFATC1,2,3" +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0004725 +name: protein tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] +synonym: "[phosphotyrosine]protein phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" RELATED [EC:3.1.3.48] +synonym: "phosphotyrosine histone phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "phosphotyrosine phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "phosphotyrosine protein phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "phosphotyrosylprotein phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "PPT-phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "protein phosphotyrosine phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "protein-tyrosine-phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "protein-tyrosine-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.48] +synonym: "PTP-phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "PTPase activity" RELATED [EC:3.1.3.48] +synonym: "tyrosine O-phosphate phosphatase activity" RELATED [EC:3.1.3.48] +synonym: "tyrosylprotein phosphatase activity" RELATED [EC:3.1.3.48] +xref: EC:3.1.3.48 +xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN +xref: Reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2" +xref: Reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR" +xref: Reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2" +xref: Reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2" +xref: Reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45" +xref: Reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)" +xref: Reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1" +xref: Reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases" +xref: Reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn" +xref: Reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)" +xref: Reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX" +xref: Reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET" +xref: Reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET" +xref: Reactome:R-HSA-74733 "Insulin receptor de-phosphorylation" +xref: Reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2" +xref: Reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1" +xref: Reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs" +xref: Reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6" +xref: Reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22" +xref: Reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70" +xref: Reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248" +xref: Reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)" +xref: Reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021" +xref: Reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248" +xref: Reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15" +xref: Reactome:R-HSA-8867658 "PTPN3 dephosphorylates MAPK12" +xref: Reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1" +xref: Reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB" +xref: Reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3" +xref: Reactome:R-HSA-9635461 "PtpA dephosphorylates GSK3A" +xref: Reactome:R-HSA-9636439 "PtpA:Ub dephosphorylates p-Y133-VPS33B" +xref: Reactome:R-HSA-9698408 "PTPRJ dephosphorylates active FLT3" +xref: Reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2" +xref: Reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B" +xref: Reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1" +xref: Reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP" +xref: RHEA:10684 +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0004726 +name: non-membrane spanning protein tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] +xref: Reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2" +xref: Reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2" +xref: Reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2" +xref: Reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR" +xref: Reactome:R-HSA-9635739 "PTPN7 dephosphorylates p-T,Y-MAPKs" +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0004727 +name: prenylated protein tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0004728 +name: obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] +comment: This term was obsoleted because it was not clearly defined. +synonym: "receptor signaling protein tyrosine phosphatase activity" EXACT [] +synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0004729 +name: oxygen-dependent protoporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25576] +synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" RELATED [EC:1.3.3.4] +xref: EC:1.3.3.4 +xref: KEGG_REACTION:R03222 +xref: MetaCyc:PROTOPORGENOXI-RXN +xref: Reactome:R-HSA-189423 "PPO oxidises PPGEN9 to PRIN9" +xref: RHEA:25576 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor +is_a: GO:0070818 ! protoporphyrinogen oxidase activity + +[Term] +id: GO:0004730 +name: pseudouridylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18337] +comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. +synonym: "5-ribosyluracil 5-phosphate synthetase activity" RELATED [EC:4.2.1.70] +synonym: "pseudouridine monophosphate synthase activity" EXACT [] +synonym: "pseudouridine monophosphate synthetase activity" RELATED [EC:4.2.1.70] +synonym: "pseudouridine-5'-phosphate glycosidase activity" EXACT [] +synonym: "pseudouridylate synthetase activity" RELATED [EC:4.2.1.70] +synonym: "pseudouridylic acid synthetase activity" RELATED [EC:4.2.1.70] +synonym: "psiUMP synthetase activity" RELATED [EC:4.2.1.70] +synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" RELATED [EC:4.2.1.70] +synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" RELATED [EC:4.2.1.70] +synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] +xref: EC:4.2.1.70 +xref: KEGG_REACTION:R01055 +xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN +xref: RHEA:18337 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004731 +name: purine-nucleoside phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] +synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] +synonym: "inosine-guanosine phosphorylase activity" RELATED [EC:2.4.2.1] +synonym: "PNPase activity" RELATED [EC:2.4.2.1] +synonym: "PUNPI" RELATED [EC:2.4.2.1] +synonym: "PUNPII" RELATED [EC:2.4.2.1] +synonym: "purine deoxynucleoside phosphorylase activity" RELATED [EC:2.4.2.1] +synonym: "purine deoxyribonucleoside phosphorylase activity" RELATED [EC:2.4.2.1] +synonym: "purine nucleoside phosphorylase activity" RELATED [EC:2.4.2.1] +synonym: "purine ribonucleoside phosphorylase activity" RELATED [EC:2.4.2.1] +synonym: "purine-nucleoside:phosphate ribosyltransferase activity" RELATED [EC:2.4.2.1] +xref: EC:2.4.2.1 +xref: MetaCyc:PNP-RXN +xref: Reactome:R-HSA-112033 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)" +xref: Reactome:R-HSA-112034 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)" +xref: Reactome:R-HSA-74242 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)" +xref: Reactome:R-HSA-74249 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)" +xref: RHEA:19805 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004732 +name: pyridoxal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide." [EC:1.2.3.8] +synonym: "pyridoxal:oxygen 4-oxidoreductase activity" RELATED [EC:1.2.3.8] +xref: EC:1.2.3.8 +xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN +xref: RHEA:23724 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0004733 +name: pyridoxamine-phosphate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] +synonym: "PdxH" RELATED [EC:1.4.3.5] +synonym: "PMP oxidase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxal 5'-phosphate synthase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxamine 5'-phosphate oxidase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxamine phosphate oxidase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.5] +synonym: "pyridoxaminephosphate oxidase deaminating" RELATED [EC:1.4.3.5] +synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" RELATED [EC:1.4.3.5] +synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.5] +xref: EC:1.4.3.5 +xref: MetaCyc:PMPOXI-RXN +xref: Reactome:R-HSA-965019 "2xPNPO:2xFMN oxidizes PDXP to PXLP" +xref: Reactome:R-HSA-965079 "2xPNPO:2xFMN oxidizes PXAP to PXLP" +xref: RHEA:15817 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0004734 +name: pyrimidodiazepine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] +synonym: "PDA synthase activity" RELATED [EC:1.5.4.1] +synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" RELATED [EC:1.5.4.1] +xref: EC:1.5.4.1 +xref: MetaCyc:1.5.4.1-RXN +xref: RHEA:10720 +is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor + +[Term] +id: GO:0004735 +name: pyrroline-5-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] +synonym: "1-pyrroline-5-carboxylate reductase activity" RELATED [EC:1.5.1.2] +synonym: "L-proline oxidase activity" RELATED [EC:1.5.1.2] +synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" RELATED [EC:1.5.1.2] +synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" RELATED [EC:1.5.1.2] +synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" RELATED [EC:1.5.1.2] +synonym: "P5CR activity" RELATED [EC:1.5.1.2] +xref: EC:1.5.1.2 +xref: MetaCyc:PYRROLINECARBREDUCT-RXN +xref: Reactome:R-HSA-6783939 "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" +xref: Reactome:R-HSA-6783955 "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" +xref: Reactome:R-HSA-70664 "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" +xref: RHEA:14109 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004736 +name: pyruvate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20844] +synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.1] +synonym: "pyruvic carboxylase activity" RELATED [EC:6.4.1.1] +xref: EC:6.4.1.1 +xref: KEGG_REACTION:R00344 +xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN +xref: Reactome:R-HSA-70501 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate" +xref: RHEA:20844 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0004737 +name: pyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] +synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" RELATED [EC:4.1.1.1] +synonym: "2-oxo-acid carboxy-lyase activity" RELATED [EC:4.1.1.1] +synonym: "alpha-carboxylase activity" RELATED [EC:4.1.1.1] +synonym: "alpha-ketoacid carboxylase activity" RELATED [EC:4.1.1.1] +synonym: "pyruvic decarboxylase activity" RELATED [EC:4.1.1.1] +xref: EC:4.1.1.1 +xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN +xref: RHEA:11628 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004738 +name: pyruvate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716720094] +synonym: "pyruvic acid dehydrogenase activity" RELATED [EC:1.2.4.1] +synonym: "pyruvic dehydrogenase activity" RELATED [EC:1.2.4.1] +xref: MetaCyc:PYRUVOXID-RXN +xref: MetaCyc:RXN0-1134 +xref: Reactome:R-HSA-71397 "lipo-PDH decarboxylates PYR to Ac-CoA" +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0004739 +name: pyruvate dehydrogenase (acetyl-transferring) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] +synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] +synonym: "PDH" RELATED [EC:1.2.4.1] +synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] +synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] +synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" RELATED [EC:1.2.4.1] +synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" RELATED [EC:1.2.4.1] +xref: EC:1.2.4.1 +xref: RHEA:19189 +is_a: GO:0004738 ! pyruvate dehydrogenase activity +is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor + +[Term] +id: GO:0004740 +name: pyruvate dehydrogenase (acetyl-transferring) kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] +synonym: "PDH kinase activity" RELATED [EC:2.7.11.2] +synonym: "PDHK" RELATED [EC:2.7.11.2] +synonym: "PDK" RELATED [EC:2.7.11.2] +synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.2] +synonym: "pyruvate dehydrogenase kinase activity" RELATED [EC:2.7.11.2] +xref: EC:2.7.11.2 +xref: MetaCyc:2.7.11.2-RXN +xref: Reactome:R-HSA-203946 "PDK isoforms phosphorylate lipo-PDH" +xref: RHEA:23052 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0004741 +name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity +namespace: molecular_function +alt_id: GO:0019906 +def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] +synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] +synonym: "phosphopyruvate dehydrogenase phosphatase activity" RELATED [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] +synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" RELATED [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.43] +synonym: "pyruvate dehydrogenase phosphatase activity" RELATED [EC:3.1.3.43] +xref: EC:3.1.3.43 +xref: MetaCyc:3.1.3.43-RXN +xref: Reactome:R-HSA-204169 "PDP dephosphorylates p-lipo-PDH" +xref: RHEA:12669 +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0004742 +name: dihydrolipoyllysine-residue acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] +synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] +synonym: "dihydrolipoate acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "dihydrolipoic transacetylase activity" RELATED [EC:2.3.1.12] +synonym: "dihydrolipoyl acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "lipoate acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "lipoate transacetylase activity" RELATED [EC:2.3.1.12] +synonym: "lipoic acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "lipoic acid acetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "lipoic transacetylase activity" RELATED [EC:2.3.1.12] +synonym: "lipoylacetyltransferase activity" RELATED [EC:2.3.1.12] +synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] +synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] +xref: EC:2.3.1.12 +is_a: GO:0016418 ! S-acetyltransferase activity +is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004743 +name: pyruvate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate." [EC:2.7.1.40, RHEA:18159] +synonym: "ATP:pyruvate 2-O-phosphotransferase activity" RELATED [EC:2.7.1.40] +synonym: "phosphoenol transphosphorylase activity" RELATED [EC:2.7.1.40] +synonym: "phosphoenolpyruvate kinase activity" RELATED [EC:2.7.1.40] +xref: EC:2.7.1.40 +xref: MetaCyc:PEPDEPHOS-RXN +xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP" +xref: RHEA:18159 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004744 +name: retinal isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24124] +synonym: "all-trans-retinal 11-cis-trans-isomerase activity" RELATED [EC:5.2.1.3] +synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] +synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] +xref: KEGG_REACTION:R02126 +xref: MetaCyc:RETINAL-ISOMERASE-RXN +xref: RHEA:24124 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0004745 +name: NAD-retinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [RHEA:21284] +synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105] +synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956] +synonym: "retinene reductase activity" BROAD [EC:1.1.1.105] +synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105] +synonym: "retinol dehydrogenase activity" BROAD [] +xref: EC:1.1.1.105 +xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL" +xref: Reactome:R-HSA-2466832 "Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA" +xref: Reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL" +xref: Reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro" +xref: Reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL" +xref: RHEA:21284 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004746 +name: riboflavin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20772] +synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" RELATED [EC:2.5.1.9] +synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] +synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] +synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] +synonym: "riboflavin synthetase activity" RELATED [EC:2.5.1.9] +synonym: "riboflavine synthase activity" RELATED [EC:2.5.1.9] +synonym: "riboflavine synthetase activity" RELATED [EC:2.5.1.9] +synonym: "vitamin B2 synthase activity" EXACT [] +xref: EC:2.5.1.9 +xref: KEGG_REACTION:R00066 +xref: MetaCyc:RIBOFLAVIN-SYN-RXN +xref: RHEA:20772 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004747 +name: ribokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] +synonym: "ATP:D-ribose 5-phosphotransferase activity" RELATED [EC:2.7.1.15] +synonym: "D-ribokinase activity" RELATED [EC:2.7.1.15] +synonym: "deoxyribokinase activity" RELATED [EC:2.7.1.15] +synonym: "ribokinase (phosphorylating)" RELATED [EC:2.7.1.15] +xref: EC:2.7.1.15 +xref: MetaCyc:RIBOKIN-RXN +xref: Reactome:R-HSA-8955844 "RBKS phosphorylates ribose to R5P" +xref: RHEA:13697 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004748 +name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor +namespace: molecular_function +alt_id: GO:0016959 +alt_id: GO:0016960 +alt_id: GO:0016961 +def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] +comment: When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. +synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" RELATED [EC:1.17.4.1] +synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" RELATED [EC:1.17.4.1] +xref: EC:1.17.4.1 +xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN +xref: Reactome:R-HSA-111751 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" +xref: Reactome:R-HSA-111804 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" +xref: RHEA:23252 +is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0004749 +name: ribose phosphate diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15609] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "5-phosphoribose pyrophosphorylase activity" RELATED [EC:2.7.6.1] +synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" RELATED [EC:2.7.6.1] +synonym: "phosphoribosyl diphosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "phosphoribosyl pyrophosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "phosphoribosyl-diphosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "phosphoribosylpyrophosphate synthase activity" RELATED [EC:2.7.6.1] +synonym: "phosphoribosylpyrophosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "PP-ribose P synthetase activity" RELATED [EC:2.7.6.1] +synonym: "PPRibP synthetase activity" RELATED [EC:2.7.6.1] +synonym: "PRPP synthetase activity" RELATED [EC:2.7.6.1] +synonym: "pyrophosphoribosylphosphate synthetase activity" RELATED [EC:2.7.6.1] +synonym: "ribophosphate pyrophosphokinase activity" RELATED [EC:2.7.6.1] +synonym: "ribose-5-phosphate pyrophosphokinase activity" RELATED [EC:2.7.6.1] +synonym: "ribose-phosphate diphosphokinase activity" RELATED [EC:2.7.6.1] +synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] +xref: EC:2.7.6.1 +xref: KEGG_REACTION:R01049 +xref: MetaCyc:PRPPSYN-RXN +xref: MetaCyc:PWY0-662 +xref: Reactome:R-HSA-111215 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate" +xref: Reactome:R-HSA-73580 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate" +xref: RHEA:15609 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0004750 +name: D-ribulose-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13677] +synonym: "D-ribulose 5-phosphate epimerase activity" RELATED [EC:5.1.3.1] +synonym: "D-ribulose phosphate-3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "D-ribulose-5-P 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "D-ribulose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "D-ribulose-5-phosphate epimerase activity" RELATED [EC:5.1.3.1] +synonym: "D-xylulose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "erythrose-4-phosphate epimerase activity" RELATED [EC:5.1.3.1] +synonym: "erythrose-4-phosphate isomerase activity" RELATED [EC:5.1.3.1] +synonym: "pentose phosphate epimerase (PPE)" RELATED [PMID:9872416] +synonym: "pentose-5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "phosphoketopentose 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "phosphoketopentose epimerase activity" RELATED [EC:5.1.3.1] +synonym: "phosphoribulose epimerase activity" RELATED [EC:5.1.3.1] +synonym: "ribulose 5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.1] +synonym: "ribulose-phosphate 3-epimerase activity" RELATED [] +synonym: "xylulose phosphate 3-epimerase activity" RELATED [EC:5.1.3.1] +xref: EC:5.1.3.1 +xref: KEGG_REACTION:R01529 +xref: MetaCyc:RIBULP3EPIM-RXN +xref: Reactome:R-HSA-199803 "xylulose 5-phosphate <=> D-ribulose 5-phosphate" +xref: Reactome:R-HSA-71303 "RPE dimers isomerise RU5P to XY5P" +xref: RHEA:13677 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0004751 +name: ribose-5-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14657] +synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] +synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] +synonym: "pentose phosphate isomerase (PPI)" EXACT [] +synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] +synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] +synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] +synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] +synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] +xref: EC:5.3.1.6 +xref: KEGG_REACTION:R01056 +xref: MetaCyc:RIB5PISOM-RXN +xref: Reactome:R-HSA-177784 "ribose 5-phosphate <=> D-ribulose 5-phosphate" +xref: Reactome:R-HSA-5660013 "Defective RPIA does not isomerize RU5P to R5P" +xref: Reactome:R-HSA-5660015 "Defective RPIA does not isomerize R5P to RU5P" +xref: Reactome:R-HSA-71306 "D-ribulose 5-phosphate <=> ribose 5-phosphate" +xref: RHEA:14657 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004753 +name: saccharopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] +synonym: "lysine-2-oxoglutarate reductase activity" RELATED [] +synonym: "lysine-ketoglutarate reductase activity" RELATED [] +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004754 +name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12440] +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7] +synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" RELATED [EC:1.5.1.7] +synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" RELATED [EC:1.5.1.7] +synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.7] +xref: EC:1.5.1.7 +xref: KEGG_REACTION:R00715 +xref: MetaCyc:1.5.1.7-RXN +xref: RHEA:12440 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0004755 +name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10020] +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.10] +synonym: "aminoadipate semialdehyde-glutamate reductase activity" RELATED [EC:1.5.1.10] +synonym: "aminoadipic semialdehyde-glutamate reductase activity" RELATED [EC:1.5.1.10] +synonym: "aminoadipic semialdehyde-glutamic reductase activity" RELATED [EC:1.5.1.10] +synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" RELATED [EC:1.5.1.10] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.10] +synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" RELATED [EC:1.5.1.10] +synonym: "saccharopine reductase activity" RELATED [EC:1.5.1.10] +xref: EC:1.5.1.10 +xref: KEGG_REACTION:R02315 +xref: MetaCyc:RXN3O-127 +xref: RHEA:10020 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0004756 +name: selenide, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18737] +synonym: "ATP:selenide, water phosphotransferase activity" RELATED [EC:2.7.9.3] +synonym: "selenide,water dikinase activity" RELATED [EC:2.7.9.3] +synonym: "selenium donor protein activity" RELATED [EC:2.7.9.3] +synonym: "selenophosphate synthase activity" EXACT [] +synonym: "selenophosphate synthetase activity" RELATED [EC:2.7.9.3] +xref: EC:2.7.9.3 +xref: KEGG_REACTION:R03595 +xref: MetaCyc:2.7.9.3-RXN +xref: Reactome:R-HSA-8959510 "SEPHS2 phosphorylates H2Se to form SELP" +xref: RHEA:18737 +xref: UM-BBD_reactionID:r0833 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0004757 +name: sepiapterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] +synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.153] +xref: EC:1.1.1.153 +xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN +xref: Reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)" +xref: Reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2" +xref: RHEA:18953 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004758 +name: serine C-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14761] +synonym: "3-oxosphinganine synthetase activity" RELATED [EC:2.3.1.50] +synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] +synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" RELATED [EC:2.3.1.50] +synonym: "serine palmitoyltransferase" BROAD [] +synonym: "SPT" RELATED [EC:2.3.1.50] +xref: EC:2.3.1.50 +xref: KEGG_REACTION:R01281 +xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN +xref: Reactome:R-HSA-428127 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2" +xref: RHEA:14761 +is_a: GO:0016454 ! C-palmitoyltransferase activity + +[Term] +id: GO:0004760 +name: serine-pyruvate transaminase activity +namespace: molecular_function +alt_id: GO:0004761 +alt_id: GO:0004762 +alt_id: GO:0004763 +def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22852] +synonym: "hydroxypyruvate:L-alanine transaminase activity" RELATED [EC:2.6.1.51] +synonym: "L-serine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.51] +synonym: "serine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.51] +synonym: "serine-pyruvate aminotransferase activity" EXACT [] +synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] +synonym: "SPT" RELATED [EC:2.6.1.51] +xref: EC:2.6.1.51 +xref: KEGG_REACTION:R00585 +xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN +xref: RHEA:22852 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0004764 +name: shikimate 3-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] +synonym: "5-dehydroshikimate reductase activity" RELATED [EC:1.1.1.25] +synonym: "5-dehydroshikimic reductase activity" RELATED [EC:1.1.1.25] +synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25] +synonym: "DHS reductase activity" BROAD [EC:1.1.1.25] +synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25] +synonym: "shikimate:NADP(+) 5-oxidoreductase activity" RELATED [EC:1.1.1.25] +synonym: "shikimate:NADP(+) oxidoreductase activity" BROAD [EC:1.1.1.25] +xref: EC:1.1.1.25 +xref: EC:1.1.1.282 +xref: KEGG_REACTION:R06847 +xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN +xref: RHEA:17737 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0004765 +name: shikimate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13121] +synonym: "ATP:shikimate 3-phosphotransferase activity" RELATED [EC:2.7.1.71] +synonym: "shikimate kinase (phosphorylating)" RELATED [EC:2.7.1.71] +synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] +xref: EC:2.7.1.71 +xref: KEGG_REACTION:R02412 +xref: MetaCyc:SHIKIMATE-KINASE-RXN +xref: RHEA:13121 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0004766 +name: spermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] +synonym: "aminopropyltransferase activity" RELATED [EC:2.5.1.16] +synonym: "putrescine aminopropyltransferase activity" RELATED [EC:2.5.1.16] +synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.16] +synonym: "SpeE" RELATED [EC:2.5.1.16] +synonym: "spermidine synthetase activity" RELATED [EC:2.5.1.16] +xref: EC:2.5.1.16 +xref: MetaCyc:SPERMIDINESYN-RXN +xref: Reactome:R-HSA-351215 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine" +xref: RHEA:12721 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004767 +name: sphingomyelin phosphodiesterase activity +namespace: molecular_function +alt_id: GO:0030230 +alt_id: GO:0030231 +def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19253] +subset: goslim_chembl +synonym: "sphingomyelin cholinephosphohydrolase activity" RELATED [EC:3.1.4.12] +synonym: "sphingomyelinase activity" EXACT [] +xref: EC:3.1.4.12 +xref: KEGG_REACTION:R02541 +xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN +xref: Reactome:R-HSA-1605797 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)" +xref: Reactome:R-HSA-1606273 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)" +xref: Reactome:R-HSA-1606288 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)" +xref: Reactome:R-HSA-1640164 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin" +xref: Reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets" +xref: RHEA:19253 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0004768 +name: stearoyl-CoA 9-desaturase activity +namespace: molecular_function +alt_id: GO:0016214 +alt_id: GO:0043735 +def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O." [RHEA:19721] +comment: Note that this function was formerly EC:1.14.99.5. +synonym: "acyl-CoA desaturase" BROAD [EC:1.14.19.1] +synonym: "delta(9)-desaturase activity" BROAD [EC:1.14.19.1] +synonym: "delta9-desaturase" BROAD [EC:1.14.19.1] +synonym: "fatty acid desaturase" BROAD [EC:1.14.19.1] +synonym: "stearoyl-CoA desaturase activity" BROAD [] +xref: EC:1.14.19.1 +xref: MetaCyc:1.14.19.1-RXN +xref: Reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA" +xref: Reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA" +xref: RHEA:19721 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0004769 +name: steroid delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] +synonym: "3-oxosteroid delta5-delta4-isomerase activity" RELATED [EC:5.3.3.1] +synonym: "3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta(5)-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta(5)-3-ketosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta(5)-3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta(5)-steroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5(or delta4)-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5-3-keto steroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5-3-ketosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5-3-oxosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5-ketosteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "delta5-steroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "hydroxysteroid isomerase activity" RELATED [EC:5.3.3.1] +synonym: "steroid D-isomerase activity" EXACT [] +synonym: "steroid isomerase activity" RELATED [EC:5.3.3.1] +xref: EC:5.3.3.1 +xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN +xref: Reactome:R-HSA-193052 "Pregn-5-ene-3,20-dione isomerizes to progesterone" +xref: Reactome:R-HSA-193073 "HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST" +xref: Reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone" +xref: Reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol" +xref: Reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL" +xref: RHEA:14709 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0004771 +name: sterol esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] +subset: goslim_chembl +synonym: "acylcholesterol lipase activity" RELATED [EC:3.1.1.13] +synonym: "cholesterase activity" RELATED [EC:3.1.1.13] +synonym: "cholesterol ester hydrolase activity" RELATED [EC:3.1.1.13] +synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] +synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] +synonym: "cholesteryl ester hydrolase activity" RELATED [EC:3.1.1.13] +synonym: "cholesteryl ester synthase activity" RELATED [EC:3.1.1.13] +synonym: "cholesteryl esterase activity" RELATED [EC:3.1.1.13] +synonym: "sterol ester hydrolase activity" RELATED [EC:3.1.1.13] +synonym: "steryl-ester acylhydrolase activity" RELATED [EC:3.1.1.13] +synonym: "triterpenol esterase activity" RELATED [EC:3.1.1.13] +xref: EC:3.1.1.13 +xref: MetaCyc:STEROL-ESTERASE-RXN +xref: Reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)" +xref: Reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters" +xref: Reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids" +xref: RHEA:10100 +is_a: GO:0016298 ! lipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004772 +name: sterol O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0017066 +def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] +synonym: "sterol-ester synthase activity" RELATED [EC:2.3.1.26] +synonym: "sterol-ester synthetase activity" RELATED [EC:2.3.1.26] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0004773 +name: steryl-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2] +synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "arylsulfatase C activity" RELATED [EC:3.1.6.2] +synonym: "dehydroepiandrosterone sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "dehydroepiandrosterone sulfate sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "phenolic steroid sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "pregnenolone sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "steroid 3-sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "steroid sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "steroid sulfate sulfohydrolase activity" RELATED [EC:3.1.6.2] +synonym: "sterol sulfatase activity" RELATED [EC:3.1.6.2] +synonym: "steryl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.2] +synonym: "steryl-sulphatase activity" EXACT [] +xref: EC:3.1.6.2 +xref: MetaCyc:STERYL-SULFATASE-RXN +xref: Reactome:R-HSA-1606839 "Steryl sulfatase hydrolyses sulfate from steroid sulfates" +xref: RHEA:19873 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0004774 +name: succinate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [GOC:ai] +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0004775 +name: succinate-CoA ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [PMID:9874242, RHEA:17661] +synonym: "succinate thiokinase activity" RELATED [EC:6.2.1.5] +synonym: "succinic thiokinase" BROAD [] +synonym: "succinyl coenzyme A synthetase" BROAD [] +synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" RELATED [] +synonym: "succinyl-CoA synthetase (ADP-forming) activity" RELATED [EC:6.2.1.5] +synonym: "succinyl-CoA synthetase activity" RELATED [] +xref: EC:6.2.1.5 +xref: KEGG_REACTION:R00405 +xref: MetaCyc:SUCCCOASYN-RXN +xref: Reactome:R-HSA-70997 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA" +xref: RHEA:17661 +is_a: GO:0004774 ! succinate-CoA ligase activity + +[Term] +id: GO:0004776 +name: succinate-CoA ligase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [RHEA:22120] +synonym: "succinate:CoA ligase (GDP-forming) activity" RELATED [EC:6.2.1.4] +synonym: "succinyl CoA synthetase activity" RELATED [] +synonym: "succinyl coenzyme A synthetase" BROAD [] +synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" RELATED [] +synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" RELATED [] +synonym: "succinyl-CoA synthetase (GDP-forming) activity" RELATED [] +xref: EC:6.2.1.4 +xref: KEGG_REACTION:R00432 +xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN +xref: Reactome:R-HSA-71775 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA" +xref: RHEA:22120 +is_a: GO:0004774 ! succinate-CoA ligase activity + +[Term] +id: GO:0004777 +name: succinate-semialdehyde dehydrogenase (NAD+) activity +namespace: molecular_function +alt_id: GO:0008952 +def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [RHEA:13217] +synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] +synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.24] +synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf] +synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.24] +synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] +synonym: "succinyl semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.24] +xref: EC:1.2.1.24 +xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-888548 "ALDH5A1 dehydrogenates SUCCSA to SUCCA" +xref: RHEA:13217 +is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0004778 +name: succinyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11516] +synonym: "succinyl coenzyme A deacylase activity" RELATED [EC:3.1.2.3] +synonym: "succinyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.3] +synonym: "succinyl-CoA acylase activity" RELATED [EC:3.1.2.3] +xref: EC:3.1.2.3 +xref: KEGG_REACTION:R00407 +xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN +xref: RHEA:11516 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0004779 +name: sulfate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] +synonym: "sulphate adenylyltransferase activity" EXACT [] +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0004780 +name: sulfate adenylyltransferase (ADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16529] +synonym: "adenosine diphosphate sulfurylase activity" RELATED [EC:2.7.7.5] +synonym: "ADP-sulfurylase activity" RELATED [EC:2.7.7.5] +synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] +synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" RELATED [EC:2.7.7.5] +synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] +xref: EC:2.7.7.5 +xref: KEGG_REACTION:R00530 +xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN +xref: RHEA:16529 +is_a: GO:0004779 ! sulfate adenylyltransferase activity + +[Term] +id: GO:0004781 +name: sulfate adenylyltransferase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] +synonym: "adenosine-5'-triphosphate sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "adenosinetriphosphate sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "adenylylsulfate pyrophosphorylase activity" RELATED [EC:2.7.7.4] +synonym: "ATP sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "ATP-sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] +synonym: "sulfate adenylate transferase activity" RELATED [EC:2.7.7.4] +synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] +synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] +xref: EC:2.7.7.4 +xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN +xref: Reactome:R-HSA-174392 "PAPSS1,2 transfer SO4(2-) group to ATP to form APS" +xref: Reactome:R-HSA-3560794 "Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS" +xref: RHEA:18133 +is_a: GO:0004779 ! sulfate adenylyltransferase activity + +[Term] +id: GO:0004782 +name: sulfinoalanine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] +synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" RELATED [EC:4.1.1.29] +synonym: "3-sulfino-L-alanine carboxy-lyase activity" RELATED [EC:4.1.1.29] +synonym: "CADCase/CSADCase activity" RELATED [EC:4.1.1.29] +synonym: "CSAD" RELATED [EC:4.1.1.29] +synonym: "CSADCase activity" RELATED [EC:4.1.1.29] +synonym: "cysteic decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "cysteine-sulfinate decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "cysteinesulfinate decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "cysteinesulfinic acid decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "L-cysteinesulfinic acid decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "sulfoalanine decarboxylase activity" RELATED [EC:4.1.1.29] +synonym: "sulphinoalanine decarboxylase activity" EXACT [] +xref: EC:4.1.1.29 +xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-1655443 "PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine" +xref: RHEA:16877 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004783 +name: sulfite reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [RHEA:13801] +synonym: "H2S-NADP oxidoreductase activity" RELATED [EC:1.8.1.2] +synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.2] +synonym: "NADPH-dependent sulfite reductase activity" RELATED [EC:1.8.1.2] +synonym: "NADPH-sulfite reductase activity" RELATED [EC:1.8.1.2] +synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] +synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.8.1.2] +synonym: "sulphite reductase (NADPH) activity" EXACT [] +xref: EC:1.8.1.2 +xref: MetaCyc:SULFITE-REDUCT-RXN +xref: RHEA:13801 +is_a: GO:0016002 ! sulfite reductase activity +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0004784 +name: superoxide dismutase activity +namespace: molecular_function +alt_id: GO:0004785 +alt_id: GO:0008382 +alt_id: GO:0008383 +alt_id: GO:0016954 +def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] +synonym: "copper, zinc superoxide dismutase activity" NARROW [] +synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] +synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] +synonym: "cuprein" RELATED [EC:1.15.1.1] +synonym: "cytocuprein" RELATED [EC:1.15.1.1] +synonym: "erythrocuprein" RELATED [EC:1.15.1.1] +synonym: "Fe-SOD" RELATED [EC:1.15.1.1] +synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] +synonym: "hemocuprein" RELATED [EC:1.15.1.1] +synonym: "hepatocuprein" RELATED [EC:1.15.1.1] +synonym: "iron superoxide dismutase activity" NARROW [] +synonym: "iron superoxide oxidoreductase" RELATED [] +synonym: "manganese superoxide dismutase activity" NARROW [] +synonym: "manganese superoxide oxidoreductase" RELATED [] +synonym: "Mn, Fe superoxide dismutase" NARROW [] +synonym: "Mn-SOD" RELATED [EC:1.15.1.1] +synonym: "nickel superoxide dismutase activity" NARROW [] +synonym: "nickel superoxide oxidoreductase" RELATED [] +synonym: "SOD" RELATED [EC:1.15.1.1] +synonym: "SOD-1" RELATED [EC:1.15.1.1] +synonym: "SOD-2" RELATED [EC:1.15.1.1] +synonym: "SOD-3" RELATED [EC:1.15.1.1] +synonym: "SOD-4" RELATED [EC:1.15.1.1] +synonym: "SODF" RELATED [EC:1.15.1.1] +synonym: "SODS" RELATED [EC:1.15.1.1] +synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] +synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] +synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] +synonym: "zinc superoxide oxidoreductase" RELATED [] +xref: EC:1.15.1.1 +xref: MetaCyc:SUPEROX-DISMUT-RXN +xref: Reactome:R-HSA-1222462 "SodB reduces superoxide to H2O2" +xref: Reactome:R-HSA-1222469 "SodC reduces superoxide to H2O2" +xref: Reactome:R-HSA-3299680 "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)" +xref: Reactome:R-HSA-3299682 "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)" +xref: Reactome:R-HSA-3299691 "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)" +xref: Reactome:R-HSA-3777112 "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)" +xref: RHEA:20696 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0004786 +name: obsolete Mn, Fe superoxide dismutase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the function is covered by an existing term. +synonym: "Mn, Fe superoxide dismutase" EXACT [] +is_obsolete: true +consider: GO:0004784 + +[Term] +id: GO:0004787 +name: thiamine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: TPP + H2O = TMP + phosphate." [GOC:ai, RHEA:27998] +synonym: "thiamin pyrophosphatase activity" EXACT [] +synonym: "thiamin-pyrophosphatase activity" EXACT [] +synonym: "thiamine pyrophosphatase activity" EXACT [] +synonym: "thiaminpyrophosphatase activity" RELATED [] +synonym: "TPPase activity" EXACT [] +xref: RHEA:27998 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0004788 +name: thiamine diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2] +synonym: "ATP:thiamin pyrophosphotransferase activity" RELATED [EC:2.7.6.2] +synonym: "ATP:thiamine diphosphotransferase activity" RELATED [EC:2.7.6.2] +synonym: "thiamin diphosphokinase activity" EXACT [] +synonym: "thiamin pyrophosphokinase activity" EXACT [] +synonym: "thiamin pyrophosphotransferase activity" RELATED [EC:2.7.6.2] +synonym: "thiamin:ATP pyrophosphotransferase activity" RELATED [EC:2.7.6.2] +synonym: "thiamine pyrophosphokinase activity" EXACT [] +synonym: "thiaminokinase activity" RELATED [EC:2.7.6.2] +synonym: "TPTase activity" RELATED [EC:2.7.6.2] +xref: EC:2.7.6.2 +xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN +xref: Reactome:R-HSA-196761 "2xTPK1:Mg2+ phosphorylates THMN" +xref: RHEA:11576 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0004789 +name: thiamine-phosphate diphosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22328] +synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.3] +synonym: "thiamin-phosphate diphosphorylase activity" EXACT [] +synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] +synonym: "thiamine monophosphate pyrophosphorylase activity" RELATED [EC:2.5.1.3] +synonym: "thiamine phosphate pyrophosphorylase activity" RELATED [EC:2.5.1.3] +synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] +synonym: "thiamine-phosphate synthase activity" RELATED [EC:2.5.1.3] +synonym: "TMP diphosphorylase activity" RELATED [EC:2.5.1.3] +synonym: "TMP pyrophosphorylase activity" RELATED [EC:2.5.1.3] +synonym: "TMP-PPase activity" RELATED [EC:2.5.1.3] +xref: EC:2.5.1.3 +xref: KEGG_REACTION:R03223 +xref: MetaCyc:THI-P-SYN-RXN +xref: RHEA:22328 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0004790 +name: thioether S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19613] +synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" RELATED [EC:2.1.1.96] +synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" RELATED [EC:2.1.1.96] +synonym: "thioether methyltransferase activity" RELATED [EC:2.1.1.96] +xref: EC:2.1.1.96 +xref: KEGG_REACTION:R02572 +xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN +xref: RHEA:19613 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004791 +name: thioredoxin-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [RHEA:20345] +synonym: "NADP--thioredoxin reductase activity" RELATED [EC:1.8.1.9] +synonym: "NADPH--thioredoxin reductase activity" RELATED [EC:1.8.1.9] +synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" RELATED [EC:1.8.1.9] +synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" RELATED [EC:1.8.1.9] +synonym: "thioredoxin disulfide reductase activity" EXACT [] +synonym: "thioredoxin reductase (NADPH) activity" EXACT [] +synonym: "thioredoxin-disulphide reductase activity" EXACT [] +synonym: "thioredoxin:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.9] +xref: EC:1.8.1.9 +xref: KEGG_REACTION:R02016 +xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN +xref: Reactome:R-HSA-1222485 "TrxB reactivates TrxA" +xref: Reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH" +xref: Reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+" +xref: Reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300" +xref: RHEA:20345 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0047134 ! protein-disulfide reductase (NAD(P)) activity + +[Term] +id: GO:0004792 +name: thiosulfate sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16881] +synonym: "rhodanase activity" RELATED [EC:2.8.1.1] +synonym: "rhodanese activity" RELATED [EC:2.8.1.1] +synonym: "thiosulfate cyanide transsulfurase activity" RELATED [EC:2.8.1.1] +synonym: "thiosulfate thiotransferase activity" RELATED [EC:2.8.1.1] +synonym: "thiosulfate:cyanide sulfurtransferase activity" RELATED [EC:2.8.1.1] +synonym: "thiosulphate sulphurtransferase activity" EXACT [] +xref: EC:2.8.1.1 +xref: KEGG_REACTION:R01931 +xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN +xref: Reactome:R-HSA-9013198 "TST transfers sulfur from S2O3(2-) to HCN to form HSCN" +xref: RHEA:16881 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0004793 +name: threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] +synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" RELATED [EC:4.1.2.5] +synonym: "L-threonine acetaldehyde-lyase activity" RELATED [EC:4.1.2.5] +synonym: "L-threonine aldolase activity" EXACT [] +xref: EC:4.1.2.5 +xref: MetaCyc:THREONINE-ALDOLASE-RXN +xref: RHEA:19625 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0004794 +name: L-threonine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] +comment: Note that this function was formerly EC:4.2.1.16. +synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] +synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" RELATED [EC:4.3.1.19] +synonym: "L-threonine deaminase activity" RELATED [EC:4.3.1.19] +synonym: "L-threonine dehydratase activity" RELATED [EC:4.3.1.19] +synonym: "L-threonine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.19] +synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] +synonym: "threonine ammonia-lyase activity" EXACT [] +synonym: "threonine deaminase activity" RELATED [EC:4.3.1.19] +synonym: "threonine dehydrase activity" RELATED [EC:4.3.1.19] +synonym: "threonine dehydratase activity" EXACT [] +xref: EC:4.3.1.19 +xref: MetaCyc:THREDEHYD-RXN +xref: RHEA:22108 +xref: UM-BBD_reactionID:r0433 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0004795 +name: threonine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] +synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" RELATED [EC:4.2.3.1] +synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" RELATED [EC:4.2.3.1] +synonym: "threonine synthetase activity" RELATED [EC:4.2.3.1] +xref: EC:4.2.3.1 +xref: MetaCyc:THRESYN-RXN +xref: RHEA:10840 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0004796 +name: thromboxane-A synthase activity +namespace: molecular_function +alt_id: GO:0008400 +def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" RELATED [EC:5.3.99.5] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" RELATED [EC:5.3.99.5] +synonym: "cytochrome P450 CYP5" NARROW [] +synonym: "thromboxane synthase activity" RELATED [EC:5.3.99.5] +synonym: "thromboxane synthetase activity" RELATED [EC:5.3.99.5] +xref: EC:5.3.99.5 +xref: KEGG_REACTION:R02268 +xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN +xref: Reactome:R-HSA-5603275 "Defective TBXAS1 does not isomerise PGH2 to TXA2" +xref: Reactome:R-HSA-76500 "TBXAS1 isomerises PGH2 to TXA2" +xref: RHEA:17137 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0004797 +name: thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] +synonym: "2'-deoxythymidine kinase activity" RELATED [EC:2.7.1.21] +synonym: "ATP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.21] +synonym: "deoxythymidine kinase (phosphorylating)" RELATED [EC:2.7.1.21] +synonym: "thymidine kinase (phosphorylating)" RELATED [EC:2.7.1.21] +xref: EC:2.7.1.21 +xref: MetaCyc:THYKI-RXN +xref: RHEA:19129 +is_a: GO:0019136 ! deoxynucleoside kinase activity + +[Term] +id: GO:0004798 +name: thymidylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] +synonym: "ATP:dTMP phosphotransferase activity" RELATED [EC:2.7.4.9] +synonym: "deoxythymidine 5'-monophosphate kinase activity" RELATED [EC:2.7.4.9] +synonym: "dTMP kinase activity" EXACT [] +synonym: "thymidine 5'-monophosphate kinase activity" RELATED [EC:2.7.4.9] +synonym: "thymidine monophosphate kinase activity" RELATED [EC:2.7.4.9] +synonym: "thymidylate monophosphate kinase activity" RELATED [EC:2.7.4.9] +synonym: "thymidylic acid kinase activity" RELATED [EC:2.7.4.9] +synonym: "thymidylic kinase activity" RELATED [EC:2.7.4.9] +synonym: "TMPK activity" RELATED [EC:2.7.4.9] +xref: EC:2.7.4.9 +xref: MetaCyc:DTMPKI-RXN +xref: RHEA:13517 +is_a: GO:0050145 ! nucleoside monophosphate kinase activity + +[Term] +id: GO:0004799 +name: thymidylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12104] +synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.45] +synonym: "dTMP synthase activity" RELATED [EC:2.1.1.45] +synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.45] +synonym: "thymidylate synthetase activity" RELATED [EC:2.1.1.45] +synonym: "TMP synthetase activity" RELATED [EC:2.1.1.45] +xref: EC:2.1.1.45 +xref: KEGG_REACTION:R02101 +xref: MetaCyc:THYMIDYLATESYN-RXN +xref: Reactome:R-HSA-73605 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate" +xref: RHEA:12104 +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0004800 +name: thyroxine 5'-deiodinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.21.99.4] +comment: Note that this was EC:3.8.1.4. +synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" RELATED [EC:1.21.99.4] +synonym: "diiodothyronine 5'-deiodinase activity" RELATED [EC:1.21.99.4] +synonym: "iodothyronine 5'-deiodinase activity" RELATED [EC:1.21.99.4] +synonym: "iodothyronine outer ring monodeiodinase activity" RELATED [EC:1.21.99.4] +synonym: "L-thyroxine iodohydrolase (reducing) activity" RELATED [EC:1.21.99.4] +synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357] +synonym: "thyroxine 5' deiodinase activity" EXACT [] +synonym: "thyroxine deiodinase activity" BROAD [] +synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.21.99.4] +synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.21.99.4] +xref: EC:1.21.99.4 +xref: MetaCyc:THYROXINE-DEIODINASE-RXN +xref: Reactome:R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine" +xref: Reactome:R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)" +xref: RHEA:19745 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004801 +name: transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [PMID:7592346, RHEA:17053] +synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2] +synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2] +synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2] +synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2] +xref: EC:2.2.1.2 +xref: MetaCyc:TRANSALDOL-RXN +xref: Reactome:R-HSA-163764 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" +xref: Reactome:R-HSA-5659989 "Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P" +xref: Reactome:R-HSA-5659998 "Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P" +xref: Reactome:R-HSA-71334 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" +xref: RHEA:17053 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0004802 +name: transketolase activity +namespace: molecular_function +def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [GOC:fmc, RHEA:10508] +synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah] +synonym: "glycoaldehyde transferase activity" RELATED [EC:2.2.1.1] +synonym: "glycolaldehydetransferase activity" RELATED [EC:2.2.1.1] +synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1] +xref: EC:2.2.1.1 +xref: MetaCyc:1TRANSKETO-RXN +xref: Reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate" +xref: Reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate" +xref: Reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" +xref: Reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate" +xref: RHEA:10508 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0004803 +name: transposase activity +namespace: molecular_function +alt_id: GO:0004804 +def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "P-element encoded transposase activity" NARROW [] +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0004805 +name: trehalose-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] +synonym: "trehalose 6-phosphatase activity" RELATED [EC:3.1.3.12] +synonym: "trehalose 6-phosphate phosphatase activity" RELATED [EC:3.1.3.12] +synonym: "trehalose phosphatase activity" EXACT [] +synonym: "trehalose-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.12] +xref: EC:3.1.3.12 +xref: MetaCyc:TREHALOSEPHOSPHA-RXN +xref: RHEA:23420 +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0004806 +name: triglyceride lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] +subset: goslim_chembl +synonym: "amano AP" RELATED [EC:3.1.1.3] +synonym: "amano B" RELATED [EC:3.1.1.3] +synonym: "amano CE" RELATED [EC:3.1.1.3] +synonym: "amano CES" RELATED [EC:3.1.1.3] +synonym: "amano P" RELATED [EC:3.1.1.3] +synonym: "amno N-AP" RELATED [EC:3.1.1.3] +synonym: "butyrinase activity" RELATED [EC:3.1.1.3] +synonym: "cacordase activity" RELATED [EC:3.1.1.3] +synonym: "capalase L" RELATED [EC:3.1.1.3] +synonym: "GA 56" RELATED [EC:3.1.1.3] +synonym: "GEH" RELATED [EC:3.1.1.3] +synonym: "glycerol ester hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "glycerol-ester hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] +synonym: "hepatic lipase" NARROW [EC:3.1.1.3] +synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] +synonym: "lipazin" RELATED [EC:3.1.1.3] +synonym: "liver lipase" NARROW [EC:3.1.1.3] +synonym: "meito MY 30" RELATED [EC:3.1.1.3] +synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] +synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] +synonym: "PPL" RELATED [EC:3.1.1.3] +synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] +synonym: "steapsin" RELATED [EC:3.1.1.3] +synonym: "TAG activity" EXACT [PMID:16054079] +synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] +synonym: "triacetinase activity" RELATED [EC:3.1.1.3] +synonym: "triacylglycerol acylhydrolase activity" RELATED [EC:3.1.1.3] +synonym: "triacylglycerol ester hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "triacylglycerol lipase activity" RELATED [EC:3.1.1.3] +synonym: "tributyrase activity" RELATED [EC:3.1.1.3] +synonym: "tributyrin esterase activity" RELATED [EC:3.1.1.3] +synonym: "tributyrinase activity" RELATED [EC:3.1.1.3] +synonym: "triglyceridase activity" RELATED [EC:3.1.1.3] +synonym: "triglyceride hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "triolein hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "tween hydrolase activity" RELATED [EC:3.1.1.3] +synonym: "tween-hydrolyzing esterase activity" RELATED [EC:3.1.1.3] +synonym: "tweenase activity" RELATED [EC:3.1.1.3] +synonym: "tweenesterase activity" RELATED [EC:3.1.1.3] +xref: EC:3.1.1.3 +xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN +xref: Reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3" +xref: Reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid" +xref: Reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA" +xref: Reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG" +xref: Reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG" +xref: RHEA:12044 +is_a: GO:0016298 ! lipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0004807 +name: triose-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18585] +synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.1] +synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.1] +synonym: "phosphotriose isomerase activity" RELATED [EC:5.3.1.1] +synonym: "triose phosphate mutase activity" RELATED [EC:5.3.1.1] +synonym: "triose phosphoisomerase activity" RELATED [EC:5.3.1.1] +synonym: "triosephosphate isomerase activity" RELATED [EC:5.3.1.1] +synonym: "triosephosphate mutase activity" RELATED [EC:5.3.1.1] +xref: EC:5.3.1.1 +xref: KEGG_REACTION:R01015 +xref: MetaCyc:TRIOSEPISOMERIZATION-RXN +xref: Reactome:R-HSA-70454 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate" +xref: Reactome:R-HSA-70481 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate" +xref: RHEA:18585 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0004808 +name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity +namespace: molecular_function +alt_id: GO:0016425 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] +synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" RELATED [EC:2.1.1.61] +synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" RELATED [EC:2.1.1.61] +synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" RELATED [EC:2.1.1.61] +xref: EC:2.1.1.61 +xref: KEGG_REACTION:R00601 +xref: MetaCyc:2.1.1.61-RXN +xref: RHEA:19569 +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004809 +name: tRNA (guanine-N2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] +synonym: "guanine-N2-methylase activity" RELATED [EC:2.1.1.32] +synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "transfer ribonucleate guanine 2-methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "transfer ribonucleate guanine N2-methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "transfer RNA guanine 2-methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" RELATED [EC:2.1.1.32] +synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" RELATED [EC:2.1.1.32] +xref: Reactome:R-HSA-6782416 "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)" +xref: Reactome:R-HSA-6786501 "TRMT11:TRMT112 methylates guanosine-10 in tRNA" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0004810 +name: tRNA adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [RHEA:14433] +synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] +synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] +synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.72] +synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] +synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate adenyltransferase activity" RELATED [EC:2.7.7.72] +synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] +synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] +synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] +synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] +synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] +synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] +synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] +xref: EC:2.7.7.72 +xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN +is_a: GO:1990817 ! RNA adenylyltransferase activity + +[Term] +id: GO:0004812 +name: aminoacyl-tRNA ligase activity +namespace: molecular_function +alt_id: GO:0016876 +alt_id: GO:0017100 +def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] +comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. +synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] +synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [] +synonym: "ligase activity, forming aminoacyl-tRNA and related compounds" BROAD [] +xref: EC:6.1.1.- +is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0004813 +name: alanine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] +synonym: "Ala-tRNA synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanine transfer RNA synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanine translase activity" RELATED [EC:6.1.1.7] +synonym: "alanine tRNA synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanine-transfer RNA ligase activity" RELATED [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleate synthase activity" RELATED [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.7] +synonym: "alanyl-tRNA synthetase activity" EXACT [] +synonym: "AlaRS" RELATED [EC:6.1.1.7] +synonym: "L-alanine:tRNAAla ligase (AMP-forming)" RELATED [EC:6.1.1.7] +xref: EC:6.1.1.7 +xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379864 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380177 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" +xref: RHEA:12540 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004814 +name: arginine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] +synonym: "arginine translase activity" RELATED [EC:6.1.1.19] +synonym: "arginine-tRNA synthetase activity" RELATED [EC:6.1.1.19] +synonym: "arginyl transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.19] +synonym: "arginyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.19] +synonym: "arginyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.19] +synonym: "arginyl-tRNA synthetase activity" EXACT [] +synonym: "L-arginine:tRNAArg ligase (AMP-forming)" RELATED [EC:6.1.1.19] +xref: EC:6.1.1.19 +xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379993 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380224 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" +xref: RHEA:20301 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004815 +name: aspartate-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] +synonym: "aspartic acid translase activity" RELATED [EC:6.1.1.12] +synonym: "aspartyl ribonucleate synthetase activity" RELATED [EC:6.1.1.12] +synonym: "aspartyl ribonucleic synthetase activity" RELATED [EC:6.1.1.12] +synonym: "aspartyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.12] +synonym: "aspartyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.12] +synonym: "aspartyl-tRNA synthetase activity" EXACT [] +synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" RELATED [EC:6.1.1.12] +xref: EC:6.1.1.12 +xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379867 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380229 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" +xref: RHEA:19649 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004816 +name: asparagine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11180] +synonym: "asparagine translase activity" RELATED [EC:6.1.1.22] +synonym: "asparaginyl transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.22] +synonym: "asparaginyl transfer RNA synthetase activity" RELATED [EC:6.1.1.22] +synonym: "asparaginyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.22] +synonym: "asparaginyl-tRNA synthetase activity" EXACT [] +synonym: "asparagyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.22] +synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" RELATED [EC:6.1.1.22] +xref: EC:6.1.1.22 +xref: KEGG_REACTION:R03648 +xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379996 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380227 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" +xref: RHEA:11180 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004817 +name: cysteine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] +synonym: "cysteine translase activity" RELATED [EC:6.1.1.16] +synonym: "cysteinyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.16] +synonym: "cysteinyl-transferRNA synthetase activity" RELATED [EC:6.1.1.16] +synonym: "cysteinyl-tRNA synthetase activity" EXACT [] +synonym: "L-cysteine:tRNACys ligase (AMP-forming)" RELATED [EC:6.1.1.16] +xref: EC:6.1.1.16 +xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" +xref: RHEA:17773 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004818 +name: glutamate-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] +synonym: "glutamate-tRNA synthetase activity" RELATED [EC:6.1.1.17] +synonym: "glutamic acid translase activity" RELATED [EC:6.1.1.17] +synonym: "glutamyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.17] +synonym: "glutamyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.17] +synonym: "glutamyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.17] +synonym: "glutamyl-tRNA synthetase activity" EXACT [] +synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" RELATED [EC:6.1.1.17] +xref: EC:6.1.1.17 +xref: MetaCyc:GLURS-RXN +xref: Reactome:R-HSA-379861 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380216 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" +xref: RHEA:23540 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004819 +name: glutamine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] +synonym: "GlnRS" RELATED [EC:6.1.1.18] +synonym: "glutamine translase activity" RELATED [EC:6.1.1.18] +synonym: "glutamine-tRNA synthetase activity" RELATED [EC:6.1.1.18] +synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] +synonym: "glutaminyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.18] +synonym: "glutaminyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.18] +synonym: "glutaminyl-tRNA synthetase activity" EXACT [] +synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" RELATED [EC:6.1.1.18] +xref: EC:6.1.1.18 +xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379982 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380241 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" +xref: RHEA:20121 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004820 +name: glycine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] +synonym: "glycine:tRNAGly ligase (AMP-forming) activity" RELATED [EC:6.1.1.14] +synonym: "glycyl translase activity" RELATED [EC:6.1.1.14] +synonym: "glycyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.14] +synonym: "glycyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.14] +synonym: "glycyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.14] +synonym: "glycyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.14 +xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-380048 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380240 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" +xref: RHEA:16013 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004821 +name: histidine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] +synonym: "histidine translase activity" RELATED [EC:6.1.1.21] +synonym: "histidyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.21] +synonym: "histidyl-tRNA synthetase activity" EXACT [] +synonym: "L-histidine:tRNAHis ligase (AMP-forming)" RELATED [EC:6.1.1.21] +xref: EC:6.1.1.21 +xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379844 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380234 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" +xref: RHEA:17313 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004822 +name: isoleucine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11060] +synonym: "isoleucine translase activity" RELATED [EC:6.1.1.5] +synonym: "isoleucine-transfer RNA ligase activity" RELATED [EC:6.1.1.5] +synonym: "isoleucine-tRNA synthetase activity" RELATED [EC:6.1.1.5] +synonym: "isoleucyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.5] +synonym: "isoleucyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.5] +synonym: "isoleucyl-tRNA synthetase activity" EXACT [] +synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" RELATED [EC:6.1.1.5] +xref: EC:6.1.1.5 +xref: KEGG_REACTION:R03656 +xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379893 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380176 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" +xref: RHEA:11060 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004823 +name: leucine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11688] +synonym: "L-leucine:tRNALeu ligase (AMP-forming)" RELATED [EC:6.1.1.4] +synonym: "leucine translase activity" RELATED [EC:6.1.1.4] +synonym: "leucine-tRNA synthetase activity" RELATED [EC:6.1.1.4] +synonym: "leucyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.4] +synonym: "leucyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.4] +synonym: "leucyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.4] +synonym: "leucyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.4 +xref: KEGG_REACTION:R03657 +xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" +xref: RHEA:11688 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004824 +name: lysine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] +synonym: "L-lysine-transfer RNA ligase activity" RELATED [EC:6.1.1.6] +synonym: "L-lysine:tRNALys ligase (AMP-forming)" RELATED [EC:6.1.1.6] +synonym: "lysine translase activity" RELATED [EC:6.1.1.6] +synonym: "lysine-tRNA synthetase activity" RELATED [EC:6.1.1.6] +synonym: "lysyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.6] +synonym: "lysyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.6] +synonym: "lysyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.6 +xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" +xref: RHEA:20792 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004825 +name: methionine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] +synonym: "L-methionine:tRNAMet ligase (AMP-forming)" RELATED [EC:6.1.1.10] +synonym: "methionine translase activity" RELATED [EC:6.1.1.10] +synonym: "methionyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.10] +synonym: "methionyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.10] +synonym: "methionyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.10] +synonym: "methionyl-tRNA synthetase activity" EXACT [] +synonym: "MetRS activity" RELATED [EC:6.1.1.10] +xref: EC:6.1.1.10 +xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379994 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380157 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" +xref: RHEA:13481 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004826 +name: phenylalanine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] +synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" RELATED [EC:6.1.1.20] +synonym: "L-phenylalanyl-tRNA synthetase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanine translase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanine-tRNA synthetase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanyl-transfer RNA ligase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanyl-tRNA ligase activity" RELATED [EC:6.1.1.20] +synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.20 +xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379848 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380203 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" +xref: RHEA:19413 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004827 +name: proline-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] +synonym: "L-proline:tRNAPro ligase (AMP-forming)" RELATED [EC:6.1.1.15] +synonym: "proline translase activity" RELATED [EC:6.1.1.15] +synonym: "prolinyl-tRNA ligase activity" RELATED [EC:6.1.1.15] +synonym: "prolyl-s-RNA synthetase activity" RELATED [EC:6.1.1.15] +synonym: "prolyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.15] +synonym: "prolyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.15] +synonym: "prolyl-transferRNA synthetase activity" RELATED [EC:6.1.1.15] +synonym: "prolyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.15 +xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379865 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380198 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" +xref: RHEA:14305 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004828 +name: serine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] +synonym: "L-serine:tRNASer ligase (AMP-forming)" RELATED [EC:6.1.1.11] +synonym: "serine translase activity" RELATED [EC:6.1.1.11] +synonym: "SerRS activity" RELATED [EC:6.1.1.11] +synonym: "seryl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.11] +synonym: "seryl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.11] +synonym: "seryl-transfer RNA synthetase activity" RELATED [EC:6.1.1.11] +synonym: "seryl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.11 +xref: MetaCyc:SERINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379992 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380239 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" +xref: RHEA:12292 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004829 +name: threonine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] +synonym: "L-threonine:tRNAThr ligase (AMP-forming)" RELATED [EC:6.1.1.3] +synonym: "threonine translase activity" RELATED [EC:6.1.1.3] +synonym: "threonine-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.3] +synonym: "threonyl ribonucleic synthetase activity" RELATED [EC:6.1.1.3] +synonym: "threonyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.3] +synonym: "threonyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.3] +synonym: "threonyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.3] +synonym: "threonyl-tRNA synthetase activity" EXACT [] +synonym: "TRS" RELATED [EC:6.1.1.3] +xref: EC:6.1.1.3 +xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-380002 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380201 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" +xref: RHEA:24624 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004830 +name: tryptophan-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] +synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" RELATED [EC:6.1.1.2] +synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" RELATED [EC:6.1.1.2] +synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" RELATED [EC:6.1.1.2] +synonym: "TrpRS activity" RELATED [EC:6.1.1.2] +synonym: "tryptophan translase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl ribonucleic synthetase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-transfer ribonucleic synthetase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-tRNA synthase activity" RELATED [EC:6.1.1.2] +synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.2 +xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" +xref: RHEA:24080 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004831 +name: tyrosine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10220] +synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" RELATED [EC:6.1.1.1] +synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" RELATED [EC:6.1.1.1] +synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" RELATED [EC:6.1.1.1] +synonym: "tyrosine translase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosine tRNA synthetase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosine-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosine-transfer RNA ligase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosyl-tRNA ligase activity" RELATED [EC:6.1.1.1] +synonym: "tyrosyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.1 +xref: KEGG_REACTION:R02918 +xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-379980 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380170 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate" +xref: RHEA:10220 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004832 +name: valine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10704] +synonym: "L-valine:tRNAVal ligase (AMP-forming)" RELATED [EC:6.1.1.9] +synonym: "valine transfer ribonucleate ligase activity" RELATED [EC:6.1.1.9] +synonym: "valine translase activity" RELATED [EC:6.1.1.9] +synonym: "valyl-transfer ribonucleate synthetase activity" RELATED [EC:6.1.1.9] +synonym: "valyl-transfer ribonucleic acid synthetase activity" RELATED [EC:6.1.1.9] +synonym: "valyl-transfer RNA synthetase activity" RELATED [EC:6.1.1.9] +synonym: "valyl-tRNA synthetase activity" EXACT [] +xref: EC:6.1.1.9 +xref: KEGG_REACTION:R03665 +xref: MetaCyc:VALINE--TRNA-LIGASE-RXN +xref: Reactome:R-HSA-380042 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" +xref: Reactome:R-HSA-380199 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" +xref: RHEA:10704 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0004833 +name: tryptophan 2,3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0004426 +def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] +synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] +synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] +synonym: "L-tryptophan 2,3-dioxygenase activity" RELATED [EC:1.13.11.11] +synonym: "L-tryptophan pyrrolase activity" RELATED [EC:1.13.11.11] +synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.11] +synonym: "TDO" RELATED [EC:1.13.11.11] +synonym: "tryptamin 2,3-dioxygenase activity" RELATED [EC:1.13.11.11] +synonym: "tryptamine 2,3-dioxygenase activity" RELATED [EC:1.13.11.11] +synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] +synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] +synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] +xref: EC:1.13.11.11 +xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN +xref: Reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK" +xref: Reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK" +xref: Reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK" +xref: RHEA:24536 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0004834 +name: tryptophan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10532] +synonym: "indoleglycerol phosphate aldolase activity" RELATED [EC:4.2.1.20] +synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" RELATED [EC:4.2.1.20] +synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] +synonym: "L-tryptophan synthetase activity" RELATED [EC:4.2.1.20] +synonym: "tryptophan desmolase activity" RELATED [EC:4.2.1.20] +synonym: "tryptophan synthetase activity" RELATED [EC:4.2.1.20] +xref: EC:4.2.1.20 +xref: KEGG_REACTION:R02722 +xref: MetaCyc:TRYPSYN-RXN +xref: RHEA:10532 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004835 +name: tubulin-tyrosine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] +synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" RELATED [EC:6.3.2.25] +synonym: "TTL activity" RELATED [EC:6.3.2.25] +synonym: "tubulinyl-tyrosine ligase activity" EXACT [] +xref: EC:6.3.2.25 +xref: MetaCyc:6.3.2.25-RXN +xref: Reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin" +xref: RHEA:17605 +is_a: GO:0016881 ! acid-amino acid ligase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0004836 +name: tyramine-beta hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0004837 +name: tyrosine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] +synonym: "L-(-)-tyrosine apodecarboxylase activity" RELATED [EC:4.1.1.25] +synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" RELATED [EC:4.1.1.25] +synonym: "L-tyrosine carboxy-lyase activity" RELATED [EC:4.1.1.25] +synonym: "L-tyrosine decarboxylase activity" RELATED [EC:4.1.1.25] +xref: EC:4.1.1.25 +xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN +xref: RHEA:14345 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004838 +name: L-tyrosine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] +synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5] +synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5] +synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5] +synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5] +synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5] +synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5] +synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5] +synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5] +synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5] +synonym: "TyrAT activity" RELATED [EC:2.6.1.5] +synonym: "tyrosine aminotransferase activity" BROAD [] +synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5] +synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] +synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] +synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5] +xref: EC:2.6.1.5 +xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-517444 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate" +xref: Reactome:R-HSA-71155 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate" +xref: RHEA:15093 +is_a: GO:0070547 ! L-tyrosine aminotransferase activity + +[Term] +id: GO:0004839 +name: ubiquitin activating enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme] +comment: The ubiquitin activating enzyme catalyzes a ligation reaction. +synonym: "E1 ubiquitin-activating enzyme" RELATED [EC:6.2.1.45] +xref: EC:6.2.1.45 +xref: Reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol" +xref: Reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol" +xref: Reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol" +xref: Reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol" +xref: Reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol" +xref: Reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol" +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0004842 +name: ubiquitin-protein transferase activity +namespace: molecular_function +alt_id: GO:0004840 +alt_id: GO:0004841 +def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] +synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tb] +synonym: "E2" RELATED [] +synonym: "E3" RELATED [] +synonym: "ubiquitin conjugating enzyme activity" NARROW [] +synonym: "ubiquitin ligase activity" NARROW [] +synonym: "ubiquitin protein ligase activity" NARROW [] +synonym: "ubiquitin protein-ligase activity" NARROW [] +synonym: "ubiquitin-conjugating enzyme activity" NARROW [] +xref: KEGG_REACTION:R03876 +xref: Reactome:R-HSA-1169394 "ISGylation of IRF3" +xref: Reactome:R-HSA-1169395 "ISGylation of viral protein NS1" +xref: Reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase" +xref: Reactome:R-HSA-1169398 "ISGylation of host protein filamin B" +xref: Reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes" +xref: Reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)" +xref: Reactome:R-HSA-1169406 "ISGylation of host proteins" +xref: Reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha" +xref: Reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha" +xref: Reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH" +xref: Reactome:R-HSA-1358789 "Self-ubiquitination of RNF41" +xref: Reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3" +xref: Reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3" +xref: Reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)" +xref: Reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" +xref: Reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2" +xref: Reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling" +xref: Reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1" +xref: Reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" +xref: Reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" +xref: Reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP" +xref: Reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" +xref: Reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" +xref: Reactome:R-HSA-179417 "Multiubiquitination of Nek2A" +xref: Reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G" +xref: Reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex" +xref: Reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85" +xref: Reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)" +xref: Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)" +xref: Reactome:R-HSA-183051 "CBL ubiquitinates Sprouty" +xref: Reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix" +xref: Reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty" +xref: Reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7" +xref: Reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21" +xref: Reactome:R-HSA-1912357 "ITCH ubiquitinates DTX" +xref: Reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand" +xref: Reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2" +xref: Reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2" +xref: Reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer" +xref: Reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1" +xref: Reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination" +xref: Reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling" +xref: Reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6" +xref: Reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6" +xref: Reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF" +xref: Reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex" +xref: Reactome:R-HSA-211734 "Ubiquitination of PAK-2p34" +xref: Reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7" +xref: Reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2" +xref: Reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3" +xref: Reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2" +xref: Reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7" +xref: Reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3" +xref: Reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3" +xref: Reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )" +xref: Reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels" +xref: Reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6" +xref: Reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants" +xref: Reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants" +xref: Reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants" +xref: Reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA" +xref: Reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56" +xref: Reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21" +xref: Reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1" +xref: Reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2" +xref: Reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1" +xref: Reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2" +xref: Reactome:R-HSA-3797226 "Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)" +xref: Reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins" +xref: Reactome:R-HSA-4332236 "CBL neddylates TGFBR2" +xref: Reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated" +xref: Reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation" +xref: Reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1" +xref: Reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates" +xref: Reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1" +xref: Reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments" +xref: Reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated" +xref: Reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP" +xref: Reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex" +xref: Reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates" +xref: Reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1" +xref: Reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1" +xref: Reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2" +xref: Reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3" +xref: Reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA" +xref: Reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH" +xref: Reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA" +xref: Reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP" +xref: Reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP" +xref: Reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3" +xref: Reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK" +xref: Reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated" +xref: Reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2" +xref: Reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2" +xref: Reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains" +xref: Reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A" +xref: Reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO" +xref: Reactome:R-HSA-75824 "Ubiquitination of Cyclin D1" +xref: Reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4" +xref: Reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3" +xref: Reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha" +xref: Reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3" +xref: Reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex" +xref: Reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" +xref: Reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated" +xref: Reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS" +xref: Reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2" +xref: Reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains" +xref: Reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation" +xref: Reactome:R-HSA-9645394 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation" +xref: Reactome:R-HSA-9645414 "Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer" +xref: Reactome:R-HSA-9688831 "STUB1 ubiquitinates RIPK3 at K55, K363" +xref: Reactome:R-HSA-9701000 "BRCA1:BARD1 heterodimer autoubiquitinates" +xref: Reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex" +xref: Reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane" +xref: Reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2" +xref: Reactome:R-HSA-983153 "E1 mediated ubiquitin activation" +xref: Reactome:R-HSA-983156 "Polyubiquitination of substrate" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0004843 +name: thiol-dependent deubiquitinase +namespace: molecular_function +alt_id: GO:0036459 +def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709] +synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746] +synonym: "deubiquitinase activity" NARROW [GOC:bf] +synonym: "deubiquitinating enzyme" NARROW [PMID:19188440] +synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442] +synonym: "thiol-dependent ubiquitin-specific protease activity" EXACT [] +synonym: "thiol-dependent ubiquitinyl hydrolase activity" EXACT [] +synonym: "ubiquitin C-terminal hydrolase" RELATED [EC:3.4.19.12] +synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl] +synonym: "ubiquitin-specific protease activity" BROAD [] +synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] +synonym: "ubiquitinyl hydrolase activity" BROAD [] +synonym: "UBP" NARROW [] +synonym: "UCH2" NARROW [] +xref: EC:3.4.19.12 +xref: Reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8" +xref: Reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1" +xref: Reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2" +xref: Reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2" +xref: Reactome:R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2" +xref: Reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling" +xref: Reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA" +xref: Reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA" +xref: Reactome:R-HSA-5688797 "ATXN3 family cleave Ub chains" +xref: Reactome:R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2" +xref: Reactome:R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN" +xref: Reactome:R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4" +xref: Reactome:R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53" +xref: Reactome:R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B" +xref: Reactome:R-HSA-5690152 "USP5 cleaves polyubiquitin" +xref: Reactome:R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A" +xref: Reactome:R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58" +xref: Reactome:R-HSA-5690196 "USP8 deubiquitinates RNF128" +xref: Reactome:R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts" +xref: Reactome:R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1" +xref: Reactome:R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex" +xref: Reactome:R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A" +xref: Reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1" +xref: Reactome:R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1" +xref: Reactome:R-HSA-5696564 "USP25 deubiquitinates DDX58" +xref: Reactome:R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1" +xref: Reactome:R-HSA-5696605 "USP12, USP26 deubiquitinate AR" +xref: Reactome:R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG" +xref: Reactome:R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins" +xref: Reactome:R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC" +xref: Reactome:R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB" +xref: Reactome:R-HSA-5696947 "USP47 deubiquitinates POLB" +xref: Reactome:R-HSA-5696958 "USP44 deubiquitinates CDC20" +xref: Reactome:R-HSA-5696960 "USP49 deubiquitinates H2B" +xref: Reactome:R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2" +xref: Reactome:R-HSA-5696997 "USP24 deubiquitinates DDB2" +xref: Reactome:R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2" +xref: Reactome:R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1" +xref: Reactome:R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10" +xref: Reactome:R-HSA-6781814 "USP19 deubiquitinates RNF123" +xref: Reactome:R-HSA-6781897 "USP11 deubiquitinates NFKBIA" +xref: Reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6" +xref: Reactome:R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR" +xref: Reactome:R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS" +xref: Reactome:R-HSA-6782820 "USP17 deubiquitinates SUDS3" +xref: Reactome:R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33" +xref: Reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48" +xref: Reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN" +xref: Reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN" +xref: Reactome:R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4" +xref: Reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin" +xref: Reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin" +xref: Reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin" +xref: Reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin" +xref: Reactome:R-HSA-8862184 "USP48 cleaves polyubiquitin" +xref: Reactome:R-HSA-8865182 "OTUD7A hydrolyses K11diUb" +xref: Reactome:R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6" +xref: Reactome:R-HSA-8873946 "OTUD3 deubiquitinates PTEN" +xref: Reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1" +xref: Reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1" +xref: Reactome:R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin" +xref: Reactome:R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin" +xref: Reactome:R-HSA-9653514 "USP17L2 deubiquitinates RCE1" +is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0101005 ! deubiquitinase activity + +[Term] +id: GO:0004844 +name: uracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623] +synonym: "uracil-DNA glycosylase activity" EXACT [] +xref: Reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase" +xref: Reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase" +is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity + +[Term] +id: GO:0004845 +name: uracil phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13017] +synonym: "UMP diphosphorylase activity" RELATED [EC:2.4.2.9] +synonym: "UMP pyrophosphorylase activity" RELATED [EC:2.4.2.9] +synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.9] +synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" RELATED [EC:2.4.2.9] +synonym: "UPRTase activity" RELATED [EC:2.4.2.9] +synonym: "uridine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.9] +synonym: "uridine monophosphate pyrophosphorylase activity" RELATED [EC:2.4.2.9] +synonym: "uridylate pyrophosphorylase activity" RELATED [EC:2.4.2.9] +synonym: "uridylic pyrophosphorylase activity" RELATED [EC:2.4.2.9] +xref: EC:2.4.2.9 +xref: KEGG_REACTION:R00966 +xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN +xref: RHEA:13017 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004846 +name: urate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3] +synonym: "urate:oxygen oxidoreductase activity" RELATED [EC:1.7.3.3] +synonym: "uric acid oxidase activity" RELATED [EC:1.7.3.3] +synonym: "uricase activity" RELATED [EC:1.7.3.3] +synonym: "uricase II activity" NARROW [EC:1.7.3.3] +xref: EC:1.7.3.3 +xref: MetaCyc:URATE-OXIDASE-RXN +xref: RHEA:21368 +xref: UM-BBD_reactionID:r1322 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0004847 +name: urea carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20896] +synonym: "ATP--urea amidolyase activity" RELATED [EC:6.3.4.6] +synonym: "UALase activity" RELATED [EC:6.3.4.6] +synonym: "UCA activity" RELATED [EC:6.3.4.6] +synonym: "urea amidolyase activity" RELATED [EC:6.3.4.6] +synonym: "urea carboxylase (hydrolysing)" RELATED [EC:6.3.4.6] +synonym: "urea carboxylase (hydrolyzing) activity" RELATED [EC:6.3.4.6] +synonym: "urea:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.3.4.6] +synonym: "urease (ATP-hydrolysing)" RELATED [EC:6.3.4.6] +synonym: "urease (ATP-hydrolyzing) activity" RELATED [EC:6.3.4.6] +xref: EC:6.3.4.6 +xref: KEGG_REACTION:R00774 +xref: MetaCyc:UREA-CARBOXYLASE-RXN +xref: RHEA:20896 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0004848 +name: ureidoglycolate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.1.116, RHEA:19809] +comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. +synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [] +xref: EC:3.5.3.19 +xref: KEGG_REACTION:R00469 +xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN +xref: RHEA:19809 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0004849 +name: uridine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] +synonym: "ATP:uridine 5'-phosphotransferase activity" RELATED [EC:2.7.1.48] +synonym: "pyrimidine ribonucleoside kinase activity" RELATED [EC:2.7.1.48] +synonym: "uridine kinase (phosphorylating)" RELATED [EC:2.7.1.48] +synonym: "uridine kinase reaction" EXACT [] +synonym: "uridine monophosphokinase activity" RELATED [EC:2.7.1.48] +synonym: "uridine phosphokinase activity" RELATED [EC:2.7.1.48] +synonym: "uridine-cytidine kinase activity" RELATED [EC:2.7.1.48] +xref: EC:2.7.1.48 +xref: MetaCyc:URIDINEKIN-RXN +xref: Reactome:R-HSA-8954327 "UCKL1 phosphorylates urindine, cytidine" +xref: RHEA:16825 +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0004850 +name: uridine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] +synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] +synonym: "UPase activity" RELATED [EC:2.4.2.3] +synonym: "UPH" RELATED [EC:2.4.2.3] +synonym: "UrdPase activity" RELATED [EC:2.4.2.3] +synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.3] +xref: EC:2.4.2.3 +xref: MetaCyc:URPHOS-RXN +xref: Reactome:R-HSA-74372 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]" +xref: Reactome:R-HSA-74376 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)" +xref: RHEA:24388 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0004851 +name: uroporphyrin-III C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] +synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" RELATED [EC:2.1.1.107] +synonym: "CobA" RELATED [EC:2.1.1.107] +synonym: "CysG" RELATED [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" RELATED [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" RELATED [EC:2.1.1.107] +synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" RELATED [EC:2.1.1.107] +synonym: "SirA" RELATED [EC:2.1.1.107] +synonym: "SUMT activity" RELATED [EC:2.1.1.107] +synonym: "urogen III methylase activity" RELATED [EC:2.1.1.107] +synonym: "uroporphyrinogen III methylase activity" RELATED [EC:2.1.1.107] +synonym: "uroporphyrinogen methyltransferase activity" RELATED [EC:2.1.1.107] +synonym: "uroporphyrinogen-III C-methyltransferase activity" RELATED [EC:2.1.1.107] +synonym: "uroporphyrinogen-III methylase activity" RELATED [EC:2.1.1.107] +synonym: "uroporphyrinogen-III methyltransferase activity" RELATED [EC:2.1.1.107] +xref: EC:2.1.1.107 +xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN +xref: RHEA:32459 +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0004852 +name: uroporphyrinogen-III synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18965] +synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" RELATED [EC:4.2.1.75] +synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" RELATED [EC:4.2.1.75] +synonym: "porphobilinogenase activity" RELATED [EC:4.2.1.75] +synonym: "URO-synthase activity" RELATED [EC:4.2.1.75] +synonym: "uroporphyrinogen III cosynthase activity" RELATED [EC:4.2.1.75] +synonym: "uroporphyrinogen isomerase activity" RELATED [EC:4.2.1.75] +synonym: "uroporphyrinogen-III cosynthase activity" RELATED [EC:4.2.1.75] +synonym: "uroporphyrinogen-III cosynthetase activity" RELATED [EC:4.2.1.75] +xref: EC:4.2.1.75 +xref: KEGG_REACTION:R03165 +xref: MetaCyc:UROGENIIISYN-RXN +xref: Reactome:R-HSA-189488 "UROS transforms HMB to URO3" +xref: RHEA:18965 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0004853 +name: uroporphyrinogen decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] +synonym: "porphyrinogen carboxy-lyase activity" RELATED [EC:4.1.1.37] +synonym: "porphyrinogen decarboxylase activity" RELATED [EC:4.1.1.37] +synonym: "uroporphyrinogen III decarboxylase activity" RELATED [EC:4.1.1.37] +synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" RELATED [EC:4.1.1.37] +synonym: "uroporphyrinogen-III carboxy-lyase activity" RELATED [EC:4.1.1.37] +xref: EC:4.1.1.37 +xref: MetaCyc:UROGENDECARBOX-RXN +xref: Reactome:R-HSA-189425 "UROD decarboxylates URO3 to COPRO3" +xref: Reactome:R-HSA-190182 "UROD decarboxylates URO1 to COPRO1" +xref: RHEA:19865 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0004854 +name: xanthine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] +synonym: "NAD-xanthine dehydrogenase activity" RELATED [EC:1.17.1.4] +synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] +synonym: "xanthine-NAD oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "xanthine/NAD(+) oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "xanthine/NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "xanthine:NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4] +xref: EC:1.17.1.4 +xref: MetaCyc:RXN0-901 +xref: RHEA:16669 +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0004855 +name: xanthine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2] +synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] +synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] +synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] +synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] +synonym: "xanthine:O(2) oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "xanthine:O2 oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "xanthine:oxygen oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "xanthine:xanthine oxidase activity" RELATED [EC:1.17.3.2] +xref: EC:1.17.3.2 +xref: MetaCyc:XANTHINE-OXIDASE-RXN +xref: Reactome:R-HSA-74247 "Hypoxanthine + H2O + O2 => Xanthine + H2O2" +xref: Reactome:R-HSA-74258 "Xanthine + H2O + O2 => Urate + H2O2" +xref: RHEA:21132 +xref: UM-BBD_enzymeID:e0781 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0004856 +name: xylulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10964] +synonym: "ATP:D-xylulose 5-phosphotransferase activity" RELATED [EC:2.7.1.17] +synonym: "D-xylulokinase activity" RELATED [EC:2.7.1.17] +synonym: "xylulokinase (phosphorylating)" RELATED [EC:2.7.1.17] +synonym: "xylulose kinase activity" RELATED [EC:2.7.1.17] +xref: EC:2.7.1.17 +xref: KEGG_REACTION:R01639 +xref: MetaCyc:XYLULOKIN-RXN +xref: Reactome:R-HSA-5662466 "XYLB phosphorylates D-xylulose" +xref: RHEA:10964 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0004857 +name: enzyme inhibitor activity +namespace: molecular_function +alt_id: GO:0048551 +def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +synonym: "metalloenzyme inhibitor activity" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0004858 +name: dUTP pyrophosphatase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0004859 +name: phospholipase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] +is_a: GO:0055102 ! lipase inhibitor activity + +[Term] +id: GO:0004860 +name: protein kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019210 ! kinase inhibitor activity +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0004861 +name: cyclin-dependent protein serine/threonine kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] +synonym: "CDK inhibitor" RELATED [] +synonym: "cyclin dependent kinase inhibitor" RELATED [] +synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] +synonym: "cyclin-dependent kinase inhibitor" RELATED [] +synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD [] +xref: Reactome:R-HSA-187934 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21" +xref: Reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21" +is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0004862 +name: cAMP-dependent protein kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] +xref: Reactome:R-HSA-180073 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function" +is_a: GO:0008603 ! cAMP-dependent protein kinase regulator activity +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0004864 +name: protein phosphatase inhibitor activity +namespace: molecular_function +alt_id: GO:1990681 +def: "Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai] +synonym: "phosphoprotein phosphatase inhibitor activity" EXACT [] +synonym: "protein phosphatase 2 inhibitor activity" NARROW [GOC:dph] +synonym: "protein phosphatase type 2A inhibitor activity" NARROW [] +is_a: GO:0019212 ! phosphatase inhibitor activity +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0004865 +name: protein serine/threonine phosphatase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb] +is_a: GO:0004864 ! protein phosphatase inhibitor activity + +[Term] +id: GO:0004866 +name: endopeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] +synonym: "alpha-2 macroglobulin" RELATED [] +synonym: "endoproteinase inhibitor" NARROW [] +synonym: "proteinase inhibitor" NARROW [] +is_a: GO:0030414 ! peptidase inhibitor activity +is_a: GO:0061135 ! endopeptidase regulator activity + +[Term] +id: GO:0004867 +name: serine-type endopeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] +synonym: "serine protease inhibitor activity" NARROW [] +synonym: "serine proteinase inhibitor activity" NARROW [] +synonym: "serpin activity" NARROW [] +xref: Reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1" +xref: Reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1" +xref: Reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin" +xref: Reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR" +xref: Reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR" +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0004868 +name: obsolete serpin +namespace: molecular_function +def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "serpin" EXACT [] +is_obsolete: true +consider: GO:0004867 + +[Term] +id: GO:0004869 +name: cysteine-type endopeptidase inhibitor activity +namespace: molecular_function +alt_id: GO:0004870 +def: "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] +synonym: "cystatin" NARROW [GOC:jl] +synonym: "cysteine protease inhibitor activity" NARROW [GOC:dph, GOC:tb] +synonym: "thiol protease inhibitor" NARROW [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0004871 +name: obsolete signal transducer activity +namespace: molecular_function +alt_id: GO:0005062 +alt_id: GO:0009369 +alt_id: GO:0009370 +def: "OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] +comment: This term was obsoleted because it was not clearly defined and is not a useful grouping term. +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW [] +synonym: "quorum sensing response regulator activity" NARROW [] +synonym: "quorum sensing signal generator activity" NARROW [] +is_obsolete: true + +[Term] +id: GO:0004873 +name: asialoglycoprotein receptor activity +namespace: molecular_function +def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein] +subset: goslim_chembl +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0004874 +name: obsolete aryl hydrocarbon receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, PMID:1325649, PMID:7493958, Wikipedia:Aryl_hydrocarbon_receptor] +comment: This term was obsoleted because it represents a gene product. +is_obsolete: true + +[Term] +id: GO:0004875 +name: complement receptor activity +namespace: molecular_function +alt_id: GO:0004942 +def: "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446] +comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. +synonym: "anaphylatoxin receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0004876 +name: complement component C3a receptor activity +namespace: molecular_function +alt_id: GO:0004943 +def: "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] +synonym: "C3a anaphylatoxin receptor activity" RELATED [] +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004877 +name: complement component C3b receptor activity +namespace: molecular_function +def: "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004878 +name: complement component C5a receptor activity +namespace: molecular_function +alt_id: GO:0004944 +def: "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] +synonym: "C5a anaphylatoxin receptor activity" RELATED [] +is_a: GO:0001847 ! opsonin receptor activity +is_a: GO:0004875 ! complement receptor activity + +[Term] +id: GO:0004879 +name: nuclear receptor activity +namespace: molecular_function +alt_id: GO:0003708 +alt_id: GO:0004880 +alt_id: GO:0004882 +alt_id: GO:0004884 +alt_id: GO:0004886 +alt_id: GO:0004887 +alt_id: GO:0008434 +alt_id: GO:0038050 +alt_id: GO:0038051 +alt_id: GO:0038052 +def: "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus." [GOC:txnOH-2018] +comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity. +synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol] +synonym: "9-cis retinoic acid receptor activity" NARROW [] +synonym: "androgen receptor activity" NARROW [] +synonym: "calcitriol receptor activity" NARROW [] +synonym: "ecdysteroid hormone receptor activity" NARROW [] +synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf] +synonym: "glucocorticoid receptor activity" NARROW [GOC:bf] +synonym: "juvenile hormone receptor activity" NARROW [] +synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] +synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf] +synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf] +synonym: "nuclear hormone receptor" NARROW [] +synonym: "retinoic acid receptor activity" NARROW [] +synonym: "retinoid-X receptor activity" NARROW [GOC:bf] +synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW [] +synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT [] +synonym: "RXR" NARROW [] +synonym: "thyroid hormone receptor activity" NARROW [] +synonym: "vitamin A receptor activity" NARROW [] +synonym: "vitamin D receptor activity" NARROW [] +synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor] +is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific +is_a: GO:0038023 ! signaling receptor activity +is_a: GO:0098531 ! ligand-activated transcription factor activity + +[Term] +id: GO:0004883 +name: glucocorticoid receptor activity +namespace: molecular_function +def: "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967] +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0004888 +name: transmembrane signaling receptor activity +namespace: molecular_function +alt_id: GO:0004926 +alt_id: GO:0099600 +def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] +comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. +synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] +synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0004890 +name: GABA-A receptor activity +namespace: molecular_function +def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. +synonym: "ionotropic GABA receptor activity" EXACT [GOC:bf] +is_a: GO:0016917 ! GABA receptor activity + +[Term] +id: GO:0004892 +name: obsolete B cell receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +synonym: "B cell receptor activity" EXACT [] +is_obsolete: true +consider: GO:0003823 + +[Term] +id: GO:0004894 +name: obsolete T cell receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +synonym: "T cell receptor activity" EXACT [] +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0004895 +name: cell adhesion receptor activity +namespace: molecular_function +def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins." [GOC:BHF-UCL, Wikipedia:Cell_adhesion] +comment: Reinstated term from obsolete. +is_a: GO:0038023 ! signaling receptor activity +is_a: GO:0098631 ! cell adhesion mediator activity + +[Term] +id: GO:0004896 +name: cytokine receptor activity +namespace: molecular_function +alt_id: GO:0004907 +def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah] +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] +synonym: "IL receptor" NARROW [] +synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0004897 +name: ciliary neurotrophic factor receptor activity +namespace: molecular_function +def: "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +synonym: "CNTF receptor activity" EXACT [GOC:mah] +synonym: "gp130" RELATED [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004898 +name: obsolete gp130 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a gene product. +synonym: "gp130" EXACT [] +is_obsolete: true +consider: GO:0004897 +consider: GO:0004915 +consider: GO:0004921 + +[Term] +id: GO:0004900 +name: erythropoietin receptor activity +namespace: molecular_function +def: "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004901 +name: granulocyte macrophage colony-stimulating factor receptor activity +namespace: molecular_function +alt_id: GO:0030525 +def: "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +synonym: "CSF-2 receptor activity" EXACT [GOC:bf] +synonym: "CSF2R" RELATED [GOC:bf] +synonym: "GM-CSF receptor activity" EXACT [] +synonym: "GMC-SF receptor activity" EXACT [] +synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004902 +name: granulocyte colony-stimulating factor receptor activity +namespace: molecular_function +alt_id: GO:0030524 +def: "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +synonym: "CSF3R" RELATED [GOC:bf] +synonym: "G-CSF receptor activity" EXACT [GOC:bf] +synonym: "granulocyte colony stimulating factor receptor activity" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004903 +name: growth hormone receptor activity +namespace: molecular_function +def: "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004904 +name: interferon receptor activity +namespace: molecular_function +def: "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096] +synonym: "IFN receptor activity" EXACT [GOC:mah] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004905 +name: type I interferon receptor activity +namespace: molecular_function +def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "interferon-alpha receptor activity" NARROW [] +synonym: "interferon-alpha/beta receptor activity" NARROW [] +synonym: "interferon-beta receptor activity" NARROW [] +synonym: "interferon-delta receptor activity" NARROW [] +synonym: "interferon-epsilon receptor activity" NARROW [] +synonym: "interferon-kappa receptor activity" NARROW [] +synonym: "interferon-omega receptor activity" NARROW [] +synonym: "interferon-tau receptor activity" NARROW [] +synonym: "interferon-zeta receptor activity" NARROW [] +synonym: "type I IFN receptor activity" EXACT [GOC:mah] +is_a: GO:0004904 ! interferon receptor activity + +[Term] +id: GO:0004906 +name: interferon-gamma receptor activity +namespace: molecular_function +def: "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383] +synonym: "IFN-gamma receptor activity" EXACT [GOC:mah] +synonym: "IFNG receptor activity" EXACT [GOC:mah] +synonym: "type II interferon receptor activity" BROAD [] +is_a: GO:0004904 ! interferon receptor activity + +[Term] +id: GO:0004908 +name: interleukin-1 receptor activity +namespace: molecular_function +def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] +synonym: "IL-1 receptor activity" EXACT [] +synonym: "IL-1R" EXACT [] +xref: Wikipedia:Interleukin-1_receptor +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004909 +name: interleukin-1, type I, activating receptor activity +namespace: molecular_function +alt_id: GO:0019967 +def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828] +synonym: "IL-1 type I, activating binding" EXACT [] +synonym: "IL-1 type I, activating receptor" EXACT [] +synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah] +synonym: "interleukin-1 type I receptor activity" EXACT [GOC:mah] +synonym: "interleukin-1, type I, activating binding" RELATED [] +is_a: GO:0004908 ! interleukin-1 receptor activity + +[Term] +id: GO:0004910 +name: interleukin-1, type II, blocking receptor activity +namespace: molecular_function +alt_id: GO:0019968 +def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828] +synonym: "IL-1 type II, blocking binding" EXACT [] +synonym: "IL-1 type II, blocking receptor" EXACT [] +synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah] +synonym: "interleukin-1 type II receptor activity" EXACT [GOC:mah] +synonym: "interleukin-1, type II, blocking binding" RELATED [] +is_a: GO:0004908 ! interleukin-1 receptor activity + +[Term] +id: GO:0004911 +name: interleukin-2 receptor activity +namespace: molecular_function +def: "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-2 receptor activity" EXACT [GOC:mah] +synonym: "IL-2R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004912 +name: interleukin-3 receptor activity +namespace: molecular_function +def: "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-3 receptor activity" EXACT [GOC:mah] +synonym: "IL-3R" EXACT [] +xref: Wikipedia:Interleukin-3_receptor +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004913 +name: interleukin-4 receptor activity +namespace: molecular_function +def: "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-4 receptor activity" EXACT [GOC:mah] +synonym: "IL-4R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004914 +name: interleukin-5 receptor activity +namespace: molecular_function +def: "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-5 receptor activity" EXACT [GOC:mah] +synonym: "IL-5R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004915 +name: interleukin-6 receptor activity +namespace: molecular_function +def: "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "gp130" RELATED [] +synonym: "IL-6 receptor activity" EXACT [GOC:mah] +synonym: "IL-6R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004917 +name: interleukin-7 receptor activity +namespace: molecular_function +def: "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-7 receptor activity" EXACT [GOC:mah] +synonym: "IL-7R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004918 +name: interleukin-8 receptor activity +namespace: molecular_function +def: "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-8 receptor activity" EXACT [GOC:mah] +synonym: "IL-8R" EXACT [] +is_a: GO:0016494 ! C-X-C chemokine receptor activity + +[Term] +id: GO:0004919 +name: interleukin-9 receptor activity +namespace: molecular_function +def: "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-9 receptor activity" EXACT [GOC:mah] +synonym: "IL-9R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004920 +name: interleukin-10 receptor activity +namespace: molecular_function +def: "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-10 receptor activity" EXACT [GOC:mah] +synonym: "IL-10R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004921 +name: interleukin-11 receptor activity +namespace: molecular_function +def: "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "gp130" RELATED [] +synonym: "IL-11 receptor activity" EXACT [GOC:mah] +synonym: "IL-11R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004923 +name: leukemia inhibitory factor receptor activity +namespace: molecular_function +alt_id: GO:0004899 +def: "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling] +synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah] +synonym: "LIF receptor activity" EXACT [GOC:mah] +is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity + +[Term] +id: GO:0004924 +name: oncostatin-M receptor activity +namespace: molecular_function +def: "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004925 +name: prolactin receptor activity +namespace: molecular_function +def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004927 +name: obsolete sevenless receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a gene product rather than an activity. +synonym: "sevenless receptor activity" EXACT [] +is_obsolete: true +consider: GO:0004714 +consider: GO:0004888 +consider: GO:0008288 + +[Term] +id: GO:0004928 +name: obsolete frizzled receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product rather than an activity. +synonym: "frizzled receptor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0042813 +consider: GO:0016055 + +[Term] +id: GO:0004929 +name: obsolete frizzled-2 receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product rather than an activity. +synonym: "frizzled-2 receptor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0042813 +consider: GO:0007223 + +[Term] +id: GO:0004930 +name: G protein-coupled receptor activity +namespace: molecular_function +alt_id: GO:0001622 +alt_id: GO:0001623 +alt_id: GO:0001624 +alt_id: GO:0001625 +alt_id: GO:0016526 +def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] +subset: goslim_chembl +synonym: "EBV-induced receptor" NARROW [] +synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] +synonym: "G protein coupled receptor activity" EXACT [] +synonym: "G protein linked receptor activity" EXACT [] +synonym: "G-protein coupled receptor activity" EXACT [] +synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] +synonym: "G-protein linked receptor activity" EXACT [] +synonym: "GPCR activity" EXACT [] +synonym: "ligand-dependent GPCR activity" EXACT [] +synonym: "Mas proto-oncogene receptor activity" NARROW [] +synonym: "orphan G protein coupled receptor activity" NARROW [] +synonym: "orphan G-protein coupled receptor activity" NARROW [] +synonym: "orphan GPCR activity" NARROW [] +synonym: "RDC1 receptor activity" NARROW [] +synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] +synonym: "SREB receptor" NARROW [] +synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] +xref: Reactome:R-HSA-114552 "G12/13 activation by PAR" +xref: Reactome:R-HSA-114558 "Gq activation by PAR" +xref: Reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" +xref: Wikipedia:GPCR +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0004931 +name: extracellularly ATP-gated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:bf, GOC:mah, PMID:9755289] +comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. +synonym: "P2X receptor" RELATED [PMID:9755289] +synonym: "purinoceptor" BROAD [] +synonym: "purinoreceptor" BROAD [] +xref: Reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+" +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity +is_a: GO:0035381 ! ATP-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0004932 +name: mating-type factor pheromone receptor activity +namespace: molecular_function +def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity +is_a: GO:0016503 ! pheromone receptor activity + +[Term] +id: GO:0004933 +name: mating-type a-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] +synonym: "class D G protein coupled receptor activity" BROAD [] +synonym: "class D G-protein coupled receptor activity" BROAD [] +synonym: "class D G-protein-coupled receptor activity" BROAD [] +synonym: "class D GPCR activity" BROAD [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity +is_a: GO:0036318 ! peptide pheromone receptor activity + +[Term] +id: GO:0004934 +name: mating-type alpha-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] +synonym: "class D G protein coupled receptor activity" BROAD [] +synonym: "class D G-protein coupled receptor activity" BROAD [] +synonym: "class D G-protein-coupled receptor activity" BROAD [] +synonym: "class D GPCR activity" BROAD [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity +is_a: GO:0036318 ! peptide pheromone receptor activity + +[Term] +id: GO:0004935 +name: adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] +synonym: "adrenoceptor activity" EXACT [] +xref: Wikipedia:Adrenergic_receptor +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:0004936 +name: alpha-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] +synonym: "alpha adrenoceptor" EXACT [] +is_a: GO:0004935 ! adrenergic receptor activity + +[Term] +id: GO:0004937 +name: alpha1-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] +synonym: "alpha1 adrenoceptor" EXACT [] +is_a: GO:0004936 ! alpha-adrenergic receptor activity + +[Term] +id: GO:0004938 +name: alpha2-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] +synonym: "alpha2 adrenoceptor" EXACT [] +is_a: GO:0004936 ! alpha-adrenergic receptor activity + +[Term] +id: GO:0004939 +name: beta-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] +synonym: "beta adrenoceptor" EXACT [] +is_a: GO:0004935 ! adrenergic receptor activity + +[Term] +id: GO:0004940 +name: beta1-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] +synonym: "beta1 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0004941 +name: beta2-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] +synonym: "beta2 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0004945 +name: angiotensin type II receptor activity +namespace: molecular_function +def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869] +is_a: GO:0001595 ! angiotensin receptor activity + +[Term] +id: GO:0004946 +name: bombesin receptor activity +namespace: molecular_function +def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004947 +name: bradykinin receptor activity +namespace: molecular_function +def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004948 +name: calcitonin receptor activity +namespace: molecular_function +def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645] +is_a: GO:0097642 ! calcitonin family receptor activity + +[Term] +id: GO:0004949 +name: cannabinoid receptor activity +namespace: molecular_function +def: "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid] +synonym: "cannaboid receptor" EXACT [] +synonym: "endocannabinoid receptor activity" NARROW [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0004950 +name: chemokine receptor activity +namespace: molecular_function +def: "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823, Wikipedia:Chemokine] +is_a: GO:0001637 ! G protein-coupled chemoattractant receptor activity +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0004951 +name: cholecystokinin receptor activity +namespace: molecular_function +def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394] +synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004952 +name: dopamine neurotransmitter receptor activity +namespace: molecular_function +def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983] +is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity + +[Term] +id: GO:0004953 +name: icosanoid receptor activity +namespace: molecular_function +def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] +synonym: "eicosanoid receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0004954 +name: prostanoid receptor activity +namespace: molecular_function +def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732] +is_a: GO:0004953 ! icosanoid receptor activity + +[Term] +id: GO:0004955 +name: prostaglandin receptor activity +namespace: molecular_function +def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732] +is_a: GO:0004954 ! prostanoid receptor activity + +[Term] +id: GO:0004956 +name: prostaglandin D receptor activity +namespace: molecular_function +def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732] +synonym: "PGD receptor activity" RELATED [] +synonym: "PGD(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004957 +name: prostaglandin E receptor activity +namespace: molecular_function +def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732] +synonym: "PGE receptor activity" RELATED [] +synonym: "PGE(2) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004958 +name: prostaglandin F receptor activity +namespace: molecular_function +def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732] +synonym: "PGF receptor activity" RELATED [] +synonym: "PGF(2-alpha) receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0004960 +name: thromboxane receptor activity +namespace: molecular_function +def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732] +synonym: "TXA receptor activity" EXACT [] +is_a: GO:0004954 ! prostanoid receptor activity + +[Term] +id: GO:0004961 +name: thromboxane A2 receptor activity +namespace: molecular_function +def: "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732] +synonym: "TXA(2) receptor activity" EXACT [] +synonym: "TXA2 receptor activity" EXACT [PMID:15242977] +is_a: GO:0004960 ! thromboxane receptor activity + +[Term] +id: GO:0004962 +name: endothelin receptor activity +namespace: molecular_function +alt_id: GO:0001599 +alt_id: GO:0001600 +def: "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265] +synonym: "endothelin-A receptor activity" NARROW [GOC:bf, PMID:8582288] +synonym: "endothelin-B receptor activity" NARROW [GOC:bf, PMID:8582288] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004963 +name: follicle-stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "follicle stimulating hormone receptor activity" EXACT [] +synonym: "FSH receptor activity" EXACT [] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004964 +name: luteinizing hormone receptor activity +namespace: molecular_function +alt_id: GO:0004976 +def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095] +synonym: "LH receptor" EXACT [PMID:18848524] +synonym: "LHR" EXACT [PMID:18848524] +synonym: "lutropin receptor" EXACT [ISBN:0198506732] +synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004965 +name: G protein-coupled GABA receptor activity +namespace: molecular_function +def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] +synonym: "G-protein coupled GABA receptor activity" EXACT [] +synonym: "GABA-B receptor activity" RELATED [GOC:bf] +synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor] +xref: Reactome:R-HSA-1013012 "Binding of Gbeta/gamma to GIRK/Kir3 channels" +xref: Reactome:R-HSA-1013013 "Association of GABA B receptor with G protein beta-gamma subunits" +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016917 ! GABA receptor activity + +[Term] +id: GO:0004966 +name: galanin receptor activity +namespace: molecular_function +def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004967 +name: glucagon receptor activity +namespace: molecular_function +def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004968 +name: gonadotropin-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah] +synonym: "GnRH receptor activity" EXACT [] +synonym: "gonadotrophin-releasing hormone receptor activity" EXACT [GOC:dph] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004969 +name: histamine receptor activity +namespace: molecular_function +def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:0004970 +name: ionotropic glutamate receptor activity +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. +is_a: GO:0008066 ! glutamate receptor activity +is_a: GO:0022824 ! transmitter-gated ion channel activity + +[Term] +id: GO:0004971 +name: AMPA glutamate receptor activity +namespace: molecular_function +def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. +synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT [] +synonym: "AMPA receptor activity" EXACT [] +is_a: GO:0004970 ! ionotropic glutamate receptor activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0004972 +name: NMDA glutamate receptor activity +namespace: molecular_function +def: "An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages." [GOC:mah, PMID:10049997] +comment: The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product. +synonym: "N-methyl-D-aspartate selective glutamate receptor activity" EXACT [] +synonym: "NMDA receptor" EXACT [] +xref: Wikipedia:NMDA_receptor +is_a: GO:0004970 ! ionotropic glutamate receptor activity +is_a: GO:0022843 ! voltage-gated cation channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0004973 +name: obsolete N-methyl-D-aspartate receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "N-methyl-D-aspartate receptor-associated protein activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0004974 +name: leukotriene receptor activity +namespace: molecular_function +def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] +is_a: GO:0004953 ! icosanoid receptor activity + +[Term] +id: GO:0004977 +name: melanocortin receptor activity +namespace: molecular_function +def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004978 +name: corticotropin receptor activity +namespace: molecular_function +def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] +synonym: "ACTH receptor activity" EXACT [] +synonym: "adrenocorticotropic hormone receptor activity" EXACT [] +synonym: "adrenocorticotropin receptor activity" EXACT [] +is_a: GO:0004977 ! melanocortin receptor activity +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004979 +name: beta-endorphin receptor activity +namespace: molecular_function +def: "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin] +synonym: "mu-opioid receptor activity" RELATED [GOC:bf] +is_a: GO:0004977 ! melanocortin receptor activity +is_a: GO:0004985 ! G protein-coupled opioid receptor activity +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004980 +name: melanocyte-stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459] +synonym: "melanocyte stimulating hormone receptor activity" EXACT [] +synonym: "melanophore-stimulating hormone receptor activity" EXACT [] +synonym: "MSH receptor activity" BROAD [] +synonym: "MSHR activity" BROAD [] +is_a: GO:0004977 ! melanocortin receptor activity + +[Term] +id: GO:0004982 +name: N-formyl peptide receptor activity +namespace: molecular_function +def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] +synonym: "Fmet-leu-phe receptor" EXACT [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004983 +name: neuropeptide Y receptor activity +namespace: molecular_function +def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004984 +name: olfactory receptor activity +namespace: molecular_function +def: "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] +synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0004985 +name: G protein-coupled opioid receptor activity +namespace: molecular_function +def: "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:20494127] +synonym: "opioid receptor activity" BROAD [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004986 +name: obsolete delta-opioid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416] +comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. +synonym: "delta-opioid receptor activity" EXACT [] +xref: Wikipedia:Delta_Opioid_receptor +is_obsolete: true +consider: GO:0038046 + +[Term] +id: GO:0004987 +name: obsolete kappa-opioid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318] +comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. +synonym: "kappa-opioid receptor activity" EXACT [] +xref: Wikipedia:Kappa_Opioid_receptor +is_obsolete: true +consider: GO:0038048 + +[Term] +id: GO:0004988 +name: obsolete mu-opioid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319] +comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. +synonym: "mu-opioid receptor activity" EXACT [] +xref: Wikipedia:Mu_Opioid_receptor +is_obsolete: true +consider: GO:0004979 +consider: GO:0038046 +consider: GO:0038047 + +[Term] +id: GO:0004989 +name: octopamine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai] +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:0004990 +name: oxytocin receptor activity +namespace: molecular_function +def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0004991 +name: parathyroid hormone receptor activity +namespace: molecular_function +def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0004992 +name: platelet activating factor receptor activity +namespace: molecular_function +def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] +synonym: "PAF receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0004993 +name: G protein-coupled serotonin receptor activity +namespace: molecular_function +alt_id: GO:0001585 +alt_id: GO:0016609 +def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:ai] +synonym: "5-HT receptor" EXACT [] +synonym: "5-hydroxytryptamine receptor" EXACT [] +synonym: "G protein coupled serotonin receptor activity" EXACT [] +synonym: "G-protein coupled serotonin receptor activity" EXACT [] +xref: Wikipedia:5-HT_receptor +is_a: GO:0008227 ! G protein-coupled amine receptor activity +is_a: GO:0099589 ! serotonin receptor activity + +[Term] +id: GO:0004994 +name: somatostatin receptor activity +namespace: molecular_function +def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin] +synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin] +synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin] +synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin] +synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin] +synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004995 +name: tachykinin receptor activity +namespace: molecular_function +def: "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0004996 +name: thyroid-stimulating hormone receptor activity +namespace: molecular_function +def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "thyroid stimulating hormone receptor activity" EXACT [] +synonym: "thyrotropin receptor" EXACT [] +synonym: "TSH receptor activity" EXACT [] +xref: Wikipedia:Thyrotropin_receptor +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0004997 +name: thyrotropin-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0004998 +name: transferrin receptor activity +namespace: molecular_function +def: "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0004999 +name: vasoactive intestinal polypeptide receptor activity +namespace: molecular_function +def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0005000 +name: vasopressin receptor activity +namespace: molecular_function +alt_id: GO:0016931 +def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] +synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0005001 +name: transmembrane receptor protein tyrosine phosphatase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] +is_a: GO:0004725 ! protein tyrosine phosphatase activity +is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity + +[Term] +id: GO:0005003 +name: ephrin receptor activity +namespace: molecular_function +def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] +synonym: "Eph receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005004 +name: GPI-linked ephrin receptor activity +namespace: molecular_function +def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] +synonym: "GPI-linked Eph receptor activity" EXACT [] +is_a: GO:0005003 ! ephrin receptor activity + +[Term] +id: GO:0005005 +name: transmembrane-ephrin receptor activity +namespace: molecular_function +def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] +synonym: "transmembrane-Eph receptor activity" EXACT [] +is_a: GO:0005003 ! ephrin receptor activity + +[Term] +id: GO:0005006 +name: epidermal growth factor-activated receptor activity +namespace: molecular_function +alt_id: GO:0005023 +def: "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "EGF receptor activity" EXACT [] +synonym: "EGFR" EXACT [] +synonym: "epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "TGF-alpha receptor activity" EXACT [] +synonym: "transforming growth factor-alpha receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005007 +name: fibroblast growth factor-activated receptor activity +namespace: molecular_function +def: "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "FGF receptor activity" EXACT [] +synonym: "FGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "FGFR" EXACT [] +synonym: "fibroblast growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005008 +name: hepatocyte growth factor-activated receptor activity +namespace: molecular_function +def: "Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "hepatocyte growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "HGF receptor activity" EXACT [] +synonym: "HGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005009 +name: insulin-activated receptor activity +namespace: molecular_function +def: "Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "insulin receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0005010 +name: insulin-like growth factor-activated receptor activity +namespace: molecular_function +def: "Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "IGF receptor activity" EXACT [] +synonym: "IGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "insulin-like growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005011 +name: macrophage colony-stimulating factor receptor activity +namespace: molecular_function +def: "Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling] +synonym: "CSF-1" NARROW [] +synonym: "Fms" NARROW [] +synonym: "M-CSF receptor activity" EXACT [GOC:bf] +synonym: "macrophage colony stimulating factor receptor activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005012 +name: obsolete Neu/ErbB-2 receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a class of receptor rather than an activity. +synonym: "Neu/ErbB-2 receptor activity" EXACT [] +is_obsolete: true +consider: GO:0043125 + +[Term] +id: GO:0005013 +name: obsolete neurotrophin TRK receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] +comment: This term was made obsolete because it represents a gene product. +synonym: "neurotrophin TRK receptor activity" EXACT [] +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0019838 +consider: GO:0043121 + +[Term] +id: GO:0005014 +name: obsolete neurotrophin TRKA receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] +comment: This term was made obsolete because it represents a gene product. +synonym: "neurotrophin TRKA receptor activity" EXACT [] +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0043121 +consider: GO:0048406 + +[Term] +id: GO:0005015 +name: obsolete neurotrophin TRKB receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] +comment: This term was made obsolete because it represents a gene product. +synonym: "neurotrophin TRKB receptor activity" EXACT [] +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0043121 +consider: GO:0048403 + +[Term] +id: GO:0005016 +name: obsolete neurotrophin TRKC receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jid] +comment: This term was made obsolete because it represents a gene product. +synonym: "neurotrophin TRKC receptor activity" EXACT [] +is_obsolete: true +consider: GO:0004714 +consider: GO:0007165 +consider: GO:0043121 + +[Term] +id: GO:0005017 +name: platelet-derived growth factor-activated receptor activity +namespace: molecular_function +def: "Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "PDGF receptor activity" EXACT [] +synonym: "PDGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "PDGFR activity" EXACT [] +synonym: "platelet-derived growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005018 +name: platelet-derived growth factor alpha-receptor activity +namespace: molecular_function +def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] +synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961] +synonym: "PDGF alpha-receptor activity" EXACT [] +is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity + +[Term] +id: GO:0005019 +name: platelet-derived growth factor beta-receptor activity +namespace: molecular_function +def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] +synonym: "betaPDGF receptor activity" RELATED [PMID:10372961] +synonym: "PDGF beta-receptor activity" EXACT [] +is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity + +[Term] +id: GO:0005020 +name: stem cell factor receptor activity +namespace: molecular_function +def: "Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217] +synonym: "KIT" RELATED [PR:000009345] +synonym: "KIT ligand receptor activity" EXACT [PR:000009345] +synonym: "KL receptor activity" EXACT [PR:000009345] +synonym: "SCF receptor activity" EXACT [PR:000009345] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005021 +name: vascular endothelial growth factor-activated receptor activity +namespace: molecular_function +alt_id: GO:0036326 +alt_id: GO:0036327 +alt_id: GO:0036328 +alt_id: GO:0036329 +alt_id: GO:0036330 +def: "Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:19909239] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "vascular endothelial growth factor E-activated receptor activity" EXACT [PMID:19909239] +synonym: "vascular endothelial growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "VEGF receptor activity" EXACT [] +synonym: "VEGF-A-activated receptor activity" NARROW [] +synonym: "VEGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "VEGF-B-activated receptor activity" NARROW [] +synonym: "VEGF-C-activated receptor activity" NARROW [] +synonym: "VEGF-D-activated receptor activity" NARROW [] +synonym: "VEGF-E-activated receptor activity" NARROW [] +synonym: "VEGFR activity" EXACT [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0005024 +name: transforming growth factor beta-activated receptor activity +namespace: molecular_function +def: "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "TGF-beta receptor activity" EXACT [] +synonym: "TGFbeta receptor activity" EXACT [] +synonym: "TGFbeta-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "TGFbetaR" EXACT [] +synonym: "transforming growth factor beta receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity + +[Term] +id: GO:0005025 +name: transforming growth factor beta receptor activity, type I +namespace: molecular_function +def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:R-HSA-170846] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "type I TGF-beta receptor activity" EXACT [] +synonym: "type I TGFbeta receptor activity" EXACT [] +synonym: "type I transforming growth factor beta receptor activity" EXACT [] +is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity + +[Term] +id: GO:0005026 +name: transforming growth factor beta receptor activity, type II +namespace: molecular_function +def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:R-HSA-170861] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "type II TGF-beta receptor activity" EXACT [] +synonym: "type II TGFbeta receptor activity" EXACT [] +synonym: "type II transforming growth factor beta receptor activity" EXACT [] +xref: Reactome:R-HSA-170843 "TGFBR2 phosphorylates TGFBR1" +is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity + +[Term] +id: GO:0005027 +name: obsolete NGF/TNF (6 C-domain) receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a protein family rather than a molecular function. +synonym: "NGF/TNF (6 C-domain) receptor activity" EXACT [] +is_obsolete: true +consider: GO:0005031 + +[Term] +id: GO:0005028 +name: obsolete CD40 receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +synonym: "CD40 receptor activity" EXACT [] +is_obsolete: true +consider: GO:0042615 + +[Term] +id: GO:0005029 +name: obsolete CD27 receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes the receptor type, and not an activity. +synonym: "CD27 receptor activity" EXACT [] +is_obsolete: true +consider: GO:0042614 + +[Term] +id: GO:0005030 +name: neurotrophin receptor activity +namespace: molecular_function +def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0005031 +name: tumor necrosis factor-activated receptor activity +namespace: molecular_function +alt_id: GO:0005032 +alt_id: GO:0005033 +def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] +synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] +synonym: "TNF receptor activity" EXACT [] +synonym: "TNF receptor activity, type I" NARROW [] +synonym: "TNF receptor activity, type II" NARROW [] +synonym: "tumor necrosis factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "tumor necrosis factor receptor activity, type I" NARROW [] +synonym: "tumor necrosis factor receptor activity, type II" NARROW [] +is_a: GO:0005035 ! death receptor activity + +[Term] +id: GO:0005034 +name: osmosensor activity +namespace: molecular_function +def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0005035 +name: death receptor activity +namespace: molecular_function +def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153] +synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0005037 +name: obsolete death receptor adaptor protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "death receptor adaptor protein activity" EXACT [] +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005038 +name: obsolete death receptor interacting protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "death receptor interacting protein activity" EXACT [] +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005039 +name: obsolete death receptor-associated factor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "death receptor-associated factor activity" EXACT [] +is_obsolete: true +consider: GO:0005123 +consider: GO:0005515 + +[Term] +id: GO:0005041 +name: low-density lipoprotein particle receptor activity +namespace: molecular_function +alt_id: GO:0008032 +def: "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis." [GOC:bf, ISBN:0198506732] +synonym: "LDL receptor" EXACT [] +synonym: "LDLR activity" EXACT [GOC:bf] +synonym: "low-density lipoprotein receptor activity" RELATED [] +xref: Reactome:R-HSA-2404131 "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol" +xref: Reactome:R-HSA-2424254 "LDLR transports extracellular CR:atREs to cytosol" +xref: Wikipedia:LDL_receptor +is_a: GO:0030228 ! lipoprotein particle receptor activity + +[Term] +id: GO:0005042 +name: netrin receptor activity +namespace: molecular_function +def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0005043 +name: netrin receptor activity involved in chemorepulsion +namespace: molecular_function +def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling] +synonym: "netrin receptor activity involved in negative chemotaxis" EXACT [GOC:bf] +synonym: "repulsive netrin receptor activity" EXACT [GOC:bf] +is_a: GO:0005042 ! netrin receptor activity + +[Term] +id: GO:0005044 +name: scavenger receptor activity +namespace: molecular_function +def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] +comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. +subset: goslim_chembl +synonym: "macrophage receptor activity" NARROW [] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0005045 +name: obsolete endoplasmic reticulum receptor activity +namespace: molecular_function +def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] +comment: This term was made obsolete because it represents cellular component and molecular function information. +synonym: "endoplasmic reticulum receptor activity" EXACT [] +is_obsolete: true +consider: GO:0038024 + +[Term] +id: GO:0005046 +name: KDEL sequence binding +namespace: molecular_function +def: "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] +synonym: "KDEL receptor activity" NARROW [] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0005047 +name: signal recognition particle binding +namespace: molecular_function +def: "Binding to a signal recognition particle." [ISBN:0198506732] +comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. +synonym: "docking protein" BROAD [] +synonym: "signal recognition particle receptor" NARROW [] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0005048 +name: signal sequence binding +namespace: molecular_function +alt_id: GO:0008249 +def: "Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] +synonym: "leader sequence binding" NARROW [] +synonym: "protein signal sequence binding" NARROW [] +synonym: "signal sequence receptor" NARROW [] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0005049 +name: nuclear export signal receptor activity +namespace: molecular_function +alt_id: GO:0008262 +def: "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport] +synonym: "exportin activity" RELATED [] +synonym: "importin-alpha binding" RELATED [] +synonym: "importin-alpha export receptor activity" NARROW [GO:0008262] +synonym: "NES receptor" EXACT [] +is_a: GO:0140142 ! nucleocytoplasmic carrier activity + +[Term] +id: GO:0005050 +name: obsolete peroxisome receptor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular component. +synonym: "peroxisome receptor" EXACT [] +is_obsolete: true +consider: GO:0005777 +consider: GO:0038023 + +[Term] +id: GO:0005052 +name: peroxisome matrix targeting signal-1 binding +namespace: molecular_function +def: "Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] +synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540] +synonym: "peroxisome targeting signal-1 binding" EXACT [] +synonym: "peroxisome targeting signal-1 receptor" NARROW [] +synonym: "PEX5" NARROW [] +synonym: "PTS1 binding" EXACT [PMID:14709540] +synonym: "PTS1 receptor" NARROW [] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0005053 +name: peroxisome matrix targeting signal-2 binding +namespace: molecular_function +def: "Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] +synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540] +synonym: "peroxisome targeting signal-2 binding" EXACT [] +synonym: "peroxisome targeting signal-2 receptor" NARROW [] +synonym: "PEX7" NARROW [] +synonym: "PTS2 binding" EXACT [PMID:14709540] +synonym: "PTS2 receptor" EXACT [] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0005054 +name: obsolete peroxisome integral membrane receptor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular component. +synonym: "Pas20p" RELATED [] +synonym: "peroxisome integral membrane receptor" EXACT [] +is_obsolete: true +consider: GO:0038023 + +[Term] +id: GO:0005055 +name: laminin receptor activity +namespace: molecular_function +def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. +is_a: GO:0098631 ! cell adhesion mediator activity + +[Term] +id: GO:0005056 +name: tiggrin receptor activity +namespace: molecular_function +def: "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0005057 +name: obsolete signal transducer activity, downstream of receptor +namespace: molecular_function +def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] +comment: This term was obsoleted because it was not clearly defined. +synonym: "intracellular signal transducer activity" EXACT [GOC:bf] +synonym: "receptor signaling protein activity" EXACT [] +synonym: "receptor signalling protein activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005061 +name: obsolete aryl hydrocarbon receptor nuclear translocator activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "aryl hydrocarbon receptor nuclear translocator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005065 +name: obsolete heterotrimeric G-protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a cellular component and not a molecular function. +synonym: "heterotrimeric G-protein" EXACT [] +is_obsolete: true +replaced_by: GO:0005834 + +[Term] +id: GO:0005066 +name: obsolete transmembrane receptor protein tyrosine kinase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "transmembrane receptor protein tyrosine kinase signaling protein activity" EXACT [] +synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0007169 +consider: GO:0035556 + +[Term] +id: GO:0005068 +name: transmembrane receptor protein tyrosine kinase adaptor activity +namespace: molecular_function +alt_id: GO:0005069 +def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848] +synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT [] +synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED [] +is_a: GO:0030159 ! signaling receptor complex adaptor activity +is_a: GO:0030971 ! receptor tyrosine kinase binding + +[Term] +id: GO:0005070 +name: obsolete SH3/SH2 adaptor activity +namespace: molecular_function +def: "OBSOLETE. Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] +comment: This term was obsoleted because molecular adaptors should be represented by the type of molecules they serve to adapt, and not by their domains. +synonym: "SH3/SH2 adaptor protein activity" NARROW [] +is_obsolete: true + +[Term] +id: GO:0005071 +name: obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "transmembrane receptor protein serine/threonine kinase signaling protein activity" EXACT [] +synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0007178 +consider: GO:0035556 + +[Term] +id: GO:0005072 +name: obsolete transforming growth factor beta receptor, cytoplasmic mediator activity +namespace: molecular_function +def: "OBSOLETE. Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] +comment: This term was obsoleted because it is redundant with other terms. +synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] +is_obsolete: true +consider: GO:0000981 + +[Term] +id: GO:0005073 +name: obsolete common-partner SMAD protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it names a family of gene products. +synonym: "common-partner SMAD protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005074 +name: obsolete inhibitory SMAD protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it names a family of gene products. +synonym: "inhibitory SMAD protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005075 +name: obsolete pathway-specific SMAD protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a family of gene products. +synonym: "pathway-specific SMAD protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005076 +name: obsolete receptor signaling protein serine/threonine kinase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "receptor signaling protein serine/threonine kinase signaling protein activity" EXACT [] +synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0035556 + +[Term] +id: GO:0005077 +name: obsolete MAP-kinase anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "MAP-kinase anchor protein activity" EXACT [] +synonym: "MAP-kinase anchoring activity" EXACT [] +is_obsolete: true +consider: GO:0008104 +consider: GO:0051019 + +[Term] +id: GO:0005078 +name: MAP-kinase scaffold activity +namespace: molecular_function +def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] +synonym: "MAP-kinase scaffold protein activity" EXACT [] +is_a: GO:0035591 ! signaling adaptor activity + +[Term] +id: GO:0005079 +name: obsolete protein kinase A anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "A-kinase anchor protein activity" EXACT [] +synonym: "AKAP activity" EXACT [] +synonym: "protein kinase A anchoring activity" EXACT [] +is_obsolete: true +consider: GO:0008104 +consider: GO:0051018 + +[Term] +id: GO:0005080 +name: protein kinase C binding +namespace: molecular_function +alt_id: GO:0072568 +alt_id: GO:0072569 +alt_id: GO:0097024 +def: "Binding to protein kinase C." [GOC:jl] +synonym: "PKC alpha binding" EXACT [] +synonym: "PKC binding" EXACT [] +synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr] +synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr] +synonym: "protein kinase C alpha binding" NARROW [] +synonym: "protein kinase C delta binding" NARROW [] +synonym: "protein kinase C eta binding" NARROW [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0005081 +name: obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "receptor signaling protein serine/threonine phosphatase signaling protein activity" EXACT [] +synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0035556 + +[Term] +id: GO:0005082 +name: obsolete receptor signaling protein tyrosine phosphatase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "receptor signaling protein tyrosine phosphatase signaling protein activity" EXACT [] +synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0035556 + +[Term] +id: GO:0005085 +name: guanyl-nucleotide exchange factor activity +namespace: molecular_function +alt_id: GO:0005086 +alt_id: GO:0005087 +alt_id: GO:0005088 +alt_id: GO:0005089 +alt_id: GO:0005090 +alt_id: GO:0008321 +alt_id: GO:0008433 +alt_id: GO:0016219 +alt_id: GO:0016220 +alt_id: GO:0017034 +alt_id: GO:0017112 +alt_id: GO:0017132 +alt_id: GO:0019839 +alt_id: GO:0030676 +def: "Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions." [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "ARF guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "cAMP-dependent guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "GDP-dissociation stimulator activity" EXACT [] +synonym: "GDS" EXACT [] +synonym: "GEF" EXACT [] +synonym: "GNRP" NARROW [] +synonym: "guanyl-nucleotide release factor activity" EXACT [] +synonym: "guanyl-nucleotide releasing factor" EXACT [] +synonym: "Rab guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Rac guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Ral guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Ran guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Rap guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Ras guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "Rho guanine nucleotide exchange factor" EXACT [] +synonym: "Rho guanyl-nucleotide exchange factor activity" NARROW [] +synonym: "RhoGEF" EXACT [] +synonym: "Sar guanyl-nucleotide exchange factor activity" NARROW [] +xref: Reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS" +xref: Reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS" +xref: Reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA" +xref: Reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP" +xref: Reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)" +xref: Reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)" +xref: Reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4" +xref: Reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers" +xref: Reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers." +xref: Reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers" +xref: Reactome:R-HSA-1433415 "Activation of RAC1" +xref: Reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1" +xref: Reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity" +xref: Reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1" +xref: Reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1" +xref: Reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL" +xref: Reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)" +xref: Reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" +xref: Reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP" +xref: Reactome:R-HSA-186834 "SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)" +xref: Reactome:R-HSA-187746 "RIT/RIN are activated" +xref: Reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth" +xref: Reactome:R-HSA-194913 "GEFs activate Rho GTPase:GDP" +xref: Reactome:R-HSA-2029445 "An unknown GEF exchanges GTP for GDP on CDC42:GDP" +xref: Reactome:R-HSA-2029451 "Activation of RAC1 by VAV" +xref: Reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO" +xref: Reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding" +xref: Reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor" +xref: Reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)" +xref: Reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)" +xref: Reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3" +xref: Reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)" +xref: Reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt" +xref: Reactome:R-HSA-2730840 "Activation of RAC1 by VAV" +xref: Reactome:R-HSA-350769 "trans-Golgi Network Coat Activation" +xref: Reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs" +xref: Reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs" +xref: Reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11" +xref: Reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi" +xref: Reactome:R-HSA-389348 "Activation of Rac1 by pVav1" +xref: Reactome:R-HSA-389350 "Activation of Cdc42 by pVav1" +xref: Reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras" +xref: Reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12" +xref: Reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it" +xref: Reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it" +xref: Reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it" +xref: Reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it" +xref: Reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it" +xref: Reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it" +xref: Reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA" +xref: Reactome:R-HSA-392870 "Gs activation by prostacyclin receptor" +xref: Reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange" +xref: Reactome:R-HSA-399938 "Activation of Rac1 by FARP2" +xref: Reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq" +xref: Reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it" +xref: Reactome:R-HSA-416530 "GPR40:fatty acid activates Gq" +xref: Reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF" +xref: Reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1" +xref: Reactome:R-HSA-418850 "Activation of Cdc42" +xref: Reactome:R-HSA-418856 "Activation of Rac1" +xref: Reactome:R-HSA-419166 "GEFs activate RhoA,B,C" +xref: Reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t" +xref: Reactome:R-HSA-428535 "Activation of RAC1 by SOS" +xref: Reactome:R-HSA-428750 "Gq activation by TP receptor" +xref: Reactome:R-HSA-428917 "G13 activation by TP receptor" +xref: Reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases" +xref: Reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases" +xref: Reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases" +xref: Reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS" +xref: Reactome:R-HSA-445064 "Activation of Rac1 by VAV2" +xref: Reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism" +xref: Reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1" +xref: Reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it" +xref: Reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A" +xref: Reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4" +xref: Reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A" +xref: Reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)" +xref: Reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)" +xref: Reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5655277 "Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange" +xref: Reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS" +xref: Reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS" +xref: Reactome:R-HSA-5694409 "Nucleotide exchange on RAB1" +xref: Reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange" +xref: Reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF" +xref: Reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane" +xref: Reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange" +xref: Reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz" +xref: Reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13" +xref: Reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange" +xref: Reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex" +xref: Reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18" +xref: Reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1" +xref: Reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET" +xref: Reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET" +xref: Reactome:R-HSA-8853307 "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" +xref: Reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A" +xref: Reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5" +xref: Reactome:R-HSA-8875568 "RAPGEF1 activates RAP1" +xref: Reactome:R-HSA-8875591 "DOCK7 activates RAC1" +xref: Reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10" +xref: Reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8" +xref: Reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9" +xref: Reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6" +xref: Reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12" +xref: Reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13" +xref: Reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14" +xref: Reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21" +xref: Reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27" +xref: Reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31" +xref: Reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7" +xref: Reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1" +xref: Reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35" +xref: Reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38" +xref: Reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39" +xref: Reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18" +xref: Reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated" +xref: Reactome:R-HSA-8982637 "Opsins binds G alpha-t" +xref: Reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)" +xref: Reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1" +xref: Reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS" +xref: Reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2" +xref: Reactome:R-HSA-9032798 "DOCK3 activates RAC1" +xref: Reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1" +xref: Reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs" +xref: Reactome:R-HSA-9607304 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3" +xref: Reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1" +xref: Reactome:R-HSA-9624845 "RCC1 stimulates GDP to GTP exchange on RAN" +xref: Reactome:R-HSA-9634418 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1" +xref: Reactome:R-HSA-9639286 "RRAGC,D exchanges GTP for GDP" +xref: Reactome:R-HSA-9640167 "RRAGA,B exchanges GDP for GTP" +xref: Reactome:R-HSA-9660824 "ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs" +xref: Reactome:R-HSA-9664991 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants" +xref: Reactome:R-HSA-9665009 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR" +xref: Reactome:R-HSA-9665404 "RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1" +xref: Reactome:R-HSA-9665408 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2" +xref: Reactome:R-HSA-9665700 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants" +xref: Reactome:R-HSA-9665707 "RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR" +xref: Reactome:R-HSA-9666428 "DOCK180 exchanges GTP for GDP on RAC1:GDP" +xref: Reactome:R-HSA-9666430 "p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP" +xref: Reactome:R-HSA-9670436 "p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS" +xref: Reactome:R-HSA-9672163 "SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672170 "SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors" +xref: Reactome:R-HSA-9695853 "FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS" +xref: Reactome:R-HSA-9703441 "SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants" +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005091 +name: guanyl-nucleotide exchange factor adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] +is_a: GO:0030674 ! protein-macromolecule adaptor activity +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005092 +name: GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] +synonym: "GDI" EXACT [] +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005093 +name: Rab GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] +is_a: GO:0005092 ! GDP-dissociation inhibitor activity + +[Term] +id: GO:0005094 +name: Rho GDP-dissociation inhibitor activity +namespace: molecular_function +def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] +is_a: GO:0005092 ! GDP-dissociation inhibitor activity + +[Term] +id: GO:0005095 +name: GTPase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] +synonym: "GIP" BROAD [] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005096 +name: GTPase activator activity +namespace: molecular_function +alt_id: GO:0005097 +alt_id: GO:0005098 +alt_id: GO:0005099 +alt_id: GO:0005100 +alt_id: GO:0005101 +alt_id: GO:0008060 +alt_id: GO:0017123 +alt_id: GO:0030675 +alt_id: GO:0046582 +def: "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] +comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. +synonym: "ARF GAP activity" NARROW [GOC:pg] +synonym: "ARF GTPase activator activity" NARROW [] +synonym: "GAP activity" EXACT [] +synonym: "Rab GAP activity" NARROW [GOC:pg] +synonym: "Rab GTPase activator activity" NARROW [] +synonym: "Rac GAP activity" NARROW [GOC:pg] +synonym: "Rac GTPase activator activity" NARROW [] +synonym: "Ral GAP activity" NARROW [GOC:pg] +synonym: "Ral GTPase activator activity" NARROW [] +synonym: "Ran GAP activity" NARROW [GOC:pg] +synonym: "Ran GTPase activator activity" NARROW [] +synonym: "RanGAP" NARROW [] +synonym: "Rap GAP activity" NARROW [GOC:pg] +synonym: "Rap GTPase activator activity" NARROW [] +synonym: "Ras GAP activity" NARROW [GOC:pg] +synonym: "Ras GTPase activator activity" NARROW [] +synonym: "Rho GAP activity" NARROW [GOC:pg] +synonym: "Rho GTPase activator activity" NARROW [] +synonym: "Sar GAP activity" NARROW [GOC:pg] +synonym: "Sar GTPase activator activity" NARROW [] +xref: Reactome:R-HSA-194922 "GAPs inactivate Rho GTPase:GTP by hydrolysis" +xref: Reactome:R-HSA-392513 "Rap1 signal termination by Rap1GAPs" +xref: Reactome:R-HSA-399935 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity" +xref: Reactome:R-HSA-4093339 "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it" +xref: Reactome:R-HSA-416546 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity" +xref: Reactome:R-HSA-416559 "Inactivation of Rho-GTP by p190RhoGAP" +xref: Reactome:R-HSA-428522 "Inactivation of RAC1" +xref: Reactome:R-HSA-428533 "Inactivation of CDC42" +xref: Reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3" +xref: Reactome:R-HSA-8985594 "MYO9B inactivates RHOA" +xref: Reactome:R-HSA-9624893 "RAN stimulates fusion of nuclear envelope (NE) membranes" +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0030695 ! GTPase regulator activity + +[Term] +id: GO:0005102 +name: signaling receptor binding +namespace: molecular_function +def: "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] +comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_plant +synonym: "receptor binding" BROAD [] +synonym: "receptor ligand" NARROW [] +synonym: "receptor-associated protein activity" RELATED [] +xref: Wikipedia:Ligand_(biochemistry) +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005104 +name: fibroblast growth factor receptor binding +namespace: molecular_function +alt_id: GO:0001521 +alt_id: GO:0005162 +def: "Binding to a fibroblast growth factor receptor (FGFR)." [GOC:ceb] +comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. +synonym: "FGF receptor binding" EXACT [] +synonym: "FGFR binding" EXACT [] +synonym: "FGFR ligand" NARROW [] +synonym: "fibroblast growth factor" BROAD [] +synonym: "fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005105 +name: type 1 fibroblast growth factor receptor binding +namespace: molecular_function +def: "Binding to a type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] +comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). +synonym: "breathless binding" NARROW [] +synonym: "breathless ligand" NARROW [] +synonym: "FGFR1 binding" BROAD [] +synonym: "FGFR1 ligand" NARROW [] +synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding + +[Term] +id: GO:0005106 +name: obsolete ephrin +namespace: molecular_function +def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "ephrin" EXACT [] +is_obsolete: true +consider: GO:0046875 + +[Term] +id: GO:0005107 +name: obsolete GPI-linked ephrin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "GPI-linked ephrin" EXACT [] +is_obsolete: true +consider: GO:0046658 +consider: GO:0046875 + +[Term] +id: GO:0005108 +name: obsolete transmembrane ephrin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "transmembrane ephrin" EXACT [] +is_obsolete: true +consider: GO:0005887 +consider: GO:0046875 + +[Term] +id: GO:0005109 +name: frizzled binding +namespace: molecular_function +alt_id: GO:0005110 +def: "Binding to a frizzled (fz) receptor." [GOC:ceb] +subset: goslim_chembl +synonym: "frizzled ligand" NARROW [] +synonym: "frizzled-2 binding" NARROW [] +synonym: "frizzled-2 ligand" NARROW [] +synonym: "fz binding" EXACT [] +synonym: "fz ligand" NARROW [] +synonym: "fz2 binding" NARROW [] +synonym: "fz2 ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0005111 +name: type 2 fibroblast growth factor receptor binding +namespace: molecular_function +def: "Binding to a type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] +comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). +synonym: "FGFR2 binding" EXACT [] +synonym: "FGFR2 ligand" NARROW [] +synonym: "heartless binding" EXACT [] +synonym: "heartless ligand" NARROW [] +synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding + +[Term] +id: GO:0005112 +name: Notch binding +namespace: molecular_function +def: "Binding to a Notch (N) protein, a surface receptor." [GOC:ceb] +synonym: "N binding" EXACT [] +synonym: "N ligand" NARROW [] +synonym: "Notch ligand" NARROW [] +synonym: "Notch receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005113 +name: patched binding +namespace: molecular_function +def: "Binding to a patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] +synonym: "patched ligand" NARROW [] +synonym: "ptc binding" EXACT [] +synonym: "ptc ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005114 +name: type II transforming growth factor beta receptor binding +namespace: molecular_function +def: "Binding to a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] +synonym: "punt binding" NARROW [] +synonym: "punt ligand" NARROW [] +synonym: "TGF-beta type II binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "transforming growth factor beta receptor type II binding" EXACT [] +synonym: "type II TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0005115 +name: receptor tyrosine kinase-like orphan receptor binding +namespace: molecular_function +def: "Binding to a receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw] +synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] +synonym: "Ror binding" BROAD [] +synonym: "Ror ligand" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005117 +name: wishful thinking binding +namespace: molecular_function +def: "Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] +synonym: "SE20 receptor binding" NARROW [] +synonym: "wishful thinking ligand" NARROW [] +synonym: "Wit binding" EXACT [] +synonym: "Wit ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005118 +name: sevenless binding +namespace: molecular_function +def: "Binding to a sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175] +synonym: "sev binding" EXACT [] +synonym: "sev ligand" NARROW [] +synonym: "sevenless ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005119 +name: smoothened binding +namespace: molecular_function +def: "Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] +synonym: "smo binding" EXACT [] +synonym: "smo ligand" NARROW [] +synonym: "smoothened ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0005121 +name: Toll binding +namespace: molecular_function +def: "Binding to a Toll protein, a transmembrane receptor." [GOC:ceb] +synonym: "Tl binding" EXACT [] +synonym: "Toll ligand" NARROW [] +synonym: "Toll receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005122 +name: torso binding +namespace: molecular_function +def: "Binding to a torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] +synonym: "tor binding" EXACT [] +synonym: "tor ligand" NARROW [] +synonym: "torso ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005123 +name: death receptor binding +namespace: molecular_function +def: "Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] +subset: goslim_chembl +synonym: "APO binding" NARROW [GOC:rl] +synonym: "death receptor adaptor protein activity" RELATED [] +synonym: "death receptor interacting protein activity" RELATED [] +synonym: "death receptor ligand" NARROW [] +synonym: "death receptor-associated factor activity" RELATED [] +synonym: "DR binding" NARROW [GOC:rl] +synonym: "EDAR binding" NARROW [GOC:rl] +synonym: "FAS binding" NARROW [GOC:rl] +synonym: "KILLER binding" NARROW [GOC:rl] +synonym: "NGFR binding" NARROW [GOC:rl] +synonym: "TNFR1 binding" NARROW [GOC:rl] +synonym: "TRAIL binding" NARROW [GOC:rl] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005124 +name: scavenger receptor binding +namespace: molecular_function +def: "Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] +synonym: "scavenger receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005125 +name: cytokine activity +namespace: molecular_function +def: "The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471, PMID:11530802] +subset: goslim_chembl +synonym: "autocrine activity" RELATED [GOC:rl] +synonym: "paracrine activity" RELATED [GOC:rl] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0005126 +name: cytokine receptor binding +namespace: molecular_function +def: "Binding to a cytokine receptor." [GOC:mah, GOC:vw] +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] +synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005127 +name: ciliary neurotrophic factor receptor binding +namespace: molecular_function +def: "Binding to a ciliary neurotrophic factor receptor." [GOC:ai] +synonym: "ciliary neurotrophic factor" NARROW [] +synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005128 +name: erythropoietin receptor binding +namespace: molecular_function +def: "Binding to an erythropoietin receptor." [GOC:ai] +synonym: "erythropoietin" NARROW [] +synonym: "erythropoietin receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005129 +name: granulocyte macrophage colony-stimulating factor receptor binding +namespace: molecular_function +def: "Binding to a granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] +synonym: "GM-CSF receptor binding" EXACT [GOC:vk] +synonym: "GM-CSF receptor ligand" NARROW [] +synonym: "GMC-SF receptor ligand" NARROW [] +synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor" NARROW [] +synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005130 +name: granulocyte colony-stimulating factor receptor binding +namespace: molecular_function +def: "Binding to a granulocyte colony-stimulating factor receptor." [GOC:ai] +synonym: "G-CSF receptor ligand" EXACT [] +synonym: "GC-SF receptor ligand" EXACT [] +synonym: "granulocyte colony stimulating factor receptor binding" EXACT [] +synonym: "granulocyte colony-stimulating factor" NARROW [] +synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005131 +name: growth hormone receptor binding +namespace: molecular_function +def: "Binding to a growth hormone receptor." [GOC:ai] +synonym: "growth hormone" NARROW [] +synonym: "growth hormone receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0051427 ! hormone receptor binding + +[Term] +id: GO:0005132 +name: type I interferon receptor binding +namespace: molecular_function +def: "Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368] +synonym: "IFNAR binding" RELATED [PMID:17502368] +synonym: "IFNAR1 binding" NARROW [PR:000008922] +synonym: "IFNAR2 binding" NARROW [PR:000008923] +synonym: "interferon-alpha/beta" NARROW [] +synonym: "interferon-alpha/beta receptor binding" EXACT [PR:000008922, PR:000008923] +synonym: "interferon-alpha/beta receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0005133 +name: interferon-gamma receptor binding +namespace: molecular_function +def: "Binding to an interferon-gamma receptor." [GOC:ai] +synonym: "interferon-gamma" NARROW [] +synonym: "interferon-gamma receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005134 +name: interleukin-2 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-2 receptor." [GOC:ai] +synonym: "IL-2" NARROW [] +synonym: "interleukin-2 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005135 +name: interleukin-3 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-3 receptor." [GOC:ai] +synonym: "IL-3" NARROW [] +synonym: "interleukin-3 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005136 +name: interleukin-4 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-4 receptor." [GOC:ai] +synonym: "IL-4" NARROW [] +synonym: "interleukin-4 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005137 +name: interleukin-5 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-5 receptor." [GOC:ai] +subset: goslim_chembl +synonym: "IL-5" NARROW [] +synonym: "interleukin-5 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005138 +name: interleukin-6 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-6 receptor." [GOC:ai] +subset: goslim_chembl +synonym: "IL-6" NARROW [] +synonym: "interleukin-6 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005139 +name: interleukin-7 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-7 receptor." [GOC:ai] +synonym: "IL-7" NARROW [] +synonym: "interleukin-7 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005140 +name: interleukin-9 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-9 receptor." [GOC:ai] +synonym: "IL-9" NARROW [] +synonym: "interleukin-9 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005141 +name: interleukin-10 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-10 receptor." [GOC:ai] +synonym: "IL-10" NARROW [] +synonym: "interleukin-10 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005142 +name: interleukin-11 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-11 receptor." [GOC:ai] +synonym: "IL-11" NARROW [] +synonym: "interleukin-11 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005143 +name: interleukin-12 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-12 receptor." [GOC:ai] +synonym: "IL-12" NARROW [] +synonym: "interleukin-12 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005144 +name: interleukin-13 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-13 receptor." [GOC:ai] +synonym: "IL-13" NARROW [] +synonym: "interleukin-13 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005145 +name: obsolete interleukin-14 receptor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an interleukin-14 receptor." [GOC:ai] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "IL-14" NARROW [] +synonym: "interleukin-14 receptor ligand" NARROW [] +is_obsolete: true + +[Term] +id: GO:0005146 +name: leukemia inhibitory factor receptor binding +namespace: molecular_function +def: "Binding to an leukemia inhibitory factor receptor." [GOC:ai] +synonym: "leukemia inhibitory factor" NARROW [] +synonym: "leukemia inhibitory factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005147 +name: oncostatin-M receptor binding +namespace: molecular_function +def: "Binding to an oncostatin-M receptor." [GOC:ai] +synonym: "oncostatin-M" NARROW [] +synonym: "oncostatin-M receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005148 +name: prolactin receptor binding +namespace: molecular_function +def: "Binding to a prolactin receptor." [GOC:ai] +synonym: "prolactin" NARROW [] +synonym: "prolactin receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005149 +name: interleukin-1 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-1 receptor." [GOC:go_curators] +synonym: "IL-1" NARROW [] +synonym: "interleukin-1 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005150 +name: interleukin-1, type I receptor binding +namespace: molecular_function +def: "Binding to a Type I interleukin-1 receptor." [GOC:ai] +synonym: "IL-1 type I" NARROW [] +synonym: "interleukin-1, type I receptor ligand" NARROW [] +is_a: GO:0005149 ! interleukin-1 receptor binding + +[Term] +id: GO:0005151 +name: interleukin-1, type II receptor binding +namespace: molecular_function +def: "Binding to a Type II interleukin-1 receptor." [GOC:ai] +synonym: "IL-1 type II" NARROW [] +synonym: "interleukin-1, type II receptor ligand" NARROW [] +is_a: GO:0005149 ! interleukin-1 receptor binding + +[Term] +id: GO:0005152 +name: interleukin-1 receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] +synonym: "IL-1ra" EXACT [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0019966 ! interleukin-1 binding +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0005153 +name: interleukin-8 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-8 receptor." [GOC:go_curators] +subset: goslim_chembl +synonym: "IL-8" NARROW [] +synonym: "interleukin-8 receptor ligand" NARROW [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0005154 +name: epidermal growth factor receptor binding +namespace: molecular_function +alt_id: GO:0008185 +def: "Binding to an epidermal growth factor receptor." [GOC:ai] +subset: goslim_chembl +synonym: "EGF" NARROW [] +synonym: "EGF receptor binding" EXACT [] +synonym: "EGF receptor ligand" NARROW [] +synonym: "EGFR binding" EXACT [] +synonym: "epidermal growth factor" NARROW [] +synonym: "epidermal growth factor receptor ligand" NARROW [] +synonym: "TGF-alpha receptor binding" EXACT [] +synonym: "TGFalpha receptor binding" EXACT [] +synonym: "transforming growth factor alpha" NARROW [] +synonym: "transforming growth factor alpha receptor binding" EXACT [] +synonym: "transforming growth factor alpha receptor ligand" NARROW [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005155 +name: obsolete epidermal growth factor receptor activating ligand activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because it represents both a biological process and a molecular function. +synonym: "EGF receptor activating ligand activity" EXACT [] +synonym: "EGFR activating ligand activity" EXACT [] +synonym: "epidermal growth factor receptor activating ligand activity" EXACT [] +is_obsolete: true +replaced_by: GO:0005154 +consider: GO:0030297 +consider: GO:0045741 + +[Term] +id: GO:0005156 +name: obsolete epidermal growth factor receptor inhibiting ligand activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because it represents both a biological process and a molecular function. +synonym: "EGF receptor inhibiting ligand activity" EXACT [] +synonym: "EGFR inhibiting ligand activity" EXACT [] +synonym: "epidermal growth factor receptor inhibiting ligand activity" EXACT [] +is_obsolete: true +replaced_by: GO:0005154 +consider: GO:0007175 +consider: GO:0030293 + +[Term] +id: GO:0005157 +name: macrophage colony-stimulating factor receptor binding +namespace: molecular_function +def: "Binding to a macrophage colony-stimulating factor receptor." [GOC:ai] +synonym: "M-CSF receptor binding" EXACT [GOC:vk] +synonym: "macrophage colony stimulating factor receptor binding" EXACT [] +synonym: "macrophage colony-stimulating factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005158 +name: insulin receptor binding +namespace: molecular_function +def: "Binding to an insulin receptor." [GOC:ai] +synonym: "insulin receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0005159 +name: insulin-like growth factor receptor binding +namespace: molecular_function +alt_id: GO:0005067 +def: "Binding to an insulin-like growth factor receptor." [GOC:jl] +synonym: "IGF receptor binding" EXACT [] +synonym: "insulin-like growth factor" NARROW [] +synonym: "insulin-like growth factor receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005160 +name: transforming growth factor beta receptor binding +namespace: molecular_function +def: "Binding to a transforming growth factor beta receptor." [GOC:ai] +synonym: "activin" RELATED [] +synonym: "inhibin" RELATED [] +synonym: "TGF-beta receptor binding" EXACT [] +synonym: "TGFbeta receptor binding" EXACT [] +synonym: "transforming growth factor beta" NARROW [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] +synonym: "transforming growth factor beta receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005161 +name: platelet-derived growth factor receptor binding +namespace: molecular_function +def: "Binding to a platelet-derived growth factor receptor." [GOC:ai] +synonym: "PDGF" NARROW [] +synonym: "PDGF receptor binding" EXACT [] +synonym: "PDGFR binding" EXACT [] +synonym: "platelet-derived growth factor" NARROW [] +synonym: "platelet-derived growth factor receptor ligand" NARROW [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005163 +name: nerve growth factor receptor binding +namespace: molecular_function +def: "Binding to a nerve growth factor receptor." [GOC:ai, PMID:15654015] +synonym: "nerve growth factor receptor ligand" NARROW [] +synonym: "neurotrophin" NARROW [] +synonym: "NGF receptor binding" EXACT [] +is_a: GO:0005123 ! death receptor binding +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005164 +name: tumor necrosis factor receptor binding +namespace: molecular_function +def: "Binding to a tumor necrosis factor receptor." [GOC:ai] +subset: goslim_chembl +synonym: "TNF receptor binding" EXACT [] +synonym: "tumor necrosis factor" NARROW [] +synonym: "tumor necrosis factor receptor ligand" NARROW [] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005165 +name: neurotrophin receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin receptor." [GOC:ai] +synonym: "neurotrophin" NARROW [] +synonym: "neurotrophin receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005166 +name: neurotrophin p75 receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin p75 receptor." [GOC:ai] +synonym: "neurotrophin p75 receptor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005167 +name: neurotrophin TRK receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin TRK receptor." [GOC:ai] +synonym: "neurotrophin TRK receptor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0005168 +name: neurotrophin TRKA receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin TRKA receptor." [GOC:ai] +synonym: "neurotrophin TRKA receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005169 +name: neurotrophin TRKB receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin TRKB receptor." [GOC:ai] +synonym: "neurotrophin TRKB receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005170 +name: neurotrophin TRKC receptor binding +namespace: molecular_function +def: "Binding to a neurotrophin TRKC receptor." [GOC:ai] +synonym: "neurotrophin TRKC receptor ligand" NARROW [] +is_a: GO:0005167 ! neurotrophin TRK receptor binding + +[Term] +id: GO:0005171 +name: hepatocyte growth factor receptor binding +namespace: molecular_function +def: "Binding to an hepatocyte growth factor receptor." [GOC:ai] +synonym: "hepatocyte growth factor" NARROW [] +synonym: "hepatocyte growth factor receptor ligand" NARROW [] +synonym: "HGF receptor binding" EXACT [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005172 +name: vascular endothelial growth factor receptor binding +namespace: molecular_function +def: "Binding to a vascular endothelial growth factor receptor." [GOC:ai] +synonym: "vascular endothelial growth factor" NARROW [] +synonym: "vascular endothelial growth factor receptor ligand" NARROW [] +synonym: "VEGF receptor binding" EXACT [] +synonym: "VEGFR binding" EXACT [] +is_a: GO:0005126 ! cytokine receptor binding +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0005173 +name: stem cell factor receptor binding +namespace: molecular_function +def: "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] +synonym: "KIT binding" NARROW [] +synonym: "SCF" NARROW [] +synonym: "SCFR binding" EXACT [] +synonym: "stem cell factor" NARROW [] +synonym: "stem cell factor receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0005174 +name: CD40 receptor binding +namespace: molecular_function +def: "Binding to CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005175 +name: CD27 receptor binding +namespace: molecular_function +def: "Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] +is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding + +[Term] +id: GO:0005176 +name: ErbB-2 class receptor binding +namespace: molecular_function +def: "Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] +synonym: "ErbB-2 class receptor ligand" NARROW [] +synonym: "HER2 receptor binding" EXACT [] +synonym: "HER2 receptor ligand" NARROW [] +synonym: "Neu receptor binding" EXACT [] +synonym: "Neu receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005177 +name: obsolete neuroligin +namespace: molecular_function +def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] +synonym: "neuroligin" EXACT [] +is_obsolete: true +consider: GO:0042043 + +[Term] +id: GO:0005178 +name: integrin binding +namespace: molecular_function +def: "Binding to an integrin." [GOC:ceb] +subset: goslim_chembl +synonym: "integrin ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0044877 ! protein-containing complex binding +is_a: GO:0050839 ! cell adhesion molecule binding + +[Term] +id: GO:0005179 +name: hormone activity +namespace: molecular_function +def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] +comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. +subset: goslim_chembl +synonym: "cAMP generating peptide activity" NARROW [] +synonym: "glycopeptide hormone" NARROW [] +synonym: "lipopeptide hormone" NARROW [] +synonym: "peptide hormone" NARROW [] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0005180 +name: obsolete peptide hormone +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +synonym: "peptide hormone" EXACT [] +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005181 +name: obsolete glycopeptide hormone +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +synonym: "glycopeptide hormone" EXACT [] +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005182 +name: obsolete lipopeptide hormone +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. +synonym: "lipopeptide hormone" EXACT [] +is_obsolete: true +consider: GO:0005179 + +[Term] +id: GO:0005183 +name: gonadotropin hormone-releasing hormone activity +namespace: molecular_function +def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone] +synonym: "GnRH activity" EXACT [ISBN:0198506732] +synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [GOC:dph] +synonym: "LH/FSH-RF" EXACT [ISBN:0198506732] +synonym: "LHRH activity" EXACT [ISBN:0198506732] +synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732] +synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732] +synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0005184 +name: neuropeptide hormone activity +namespace: molecular_function +def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] +subset: goslim_chembl +synonym: "neurohormone" EXACT [] +xref: Wikipedia:Neurohormone +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0005185 +name: neurohypophyseal hormone activity +namespace: molecular_function +def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634] +synonym: "neurohypophysial hormone activity" EXACT [GOC:mah] +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0005186 +name: pheromone activity +namespace: molecular_function +def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732] +comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0005187 +name: obsolete storage protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular location rather than a function. +synonym: "storage protein" EXACT [] +is_obsolete: true +replaced_by: GO:0045735 + +[Term] +id: GO:0005188 +name: obsolete larval serum protein (sensu Insecta) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "arylphorin" NARROW [] +synonym: "larval serum protein (sensu Insecta)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005189 +name: obsolete milk protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "milk protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005190 +name: obsolete seminal fluid protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "seminal fluid protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005191 +name: obsolete acidic epididymal glycoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. +synonym: "acidic epididymal glycoprotein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005192 +name: obsolete urinary protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "urinary protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005193 +name: obsolete major urinary protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "major urinary protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005194 +name: obsolete cell adhesion molecule activity +namespace: molecular_function +def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732] +comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. +synonym: "cell adhesion molecule activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0030246 +consider: GO:0050839 +consider: GO:0098631 + +[Term] +id: GO:0005198 +name: structural molecule activity +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell." [GOC:mah, GOC:vw] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005199 +name: structural constituent of cell wall +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005200 +name: structural constituent of cytoskeleton +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] +subset: goslim_drosophila +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005201 +name: extracellular matrix structural constituent +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] +comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019 +subset: goslim_drosophila +synonym: "core extracellular matrix" BROAD [] +synonym: "core matrisome" BROAD [] +synonym: "extracellular matrix glycoprotein" NARROW [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005202 +name: obsolete collagen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "collagen" EXACT [] +is_obsolete: true +consider: GO:0005581 + +[Term] +id: GO:0005203 +name: obsolete proteoglycan +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +synonym: "proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005204 +name: obsolete chondroitin sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +synonym: "chondroitin sulfate proteoglycan" EXACT [] +synonym: "chondroitin sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005205 +name: obsolete chondroitin sulfate/dermatan sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. +synonym: "chondroitin sulfate/dermatan sulfate proteoglycan" EXACT [] +synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005206 +name: obsolete heparin sulfate proteoglycan +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "heparin sulfate proteoglycan" EXACT [] +synonym: "heparin sulphate proteoglycan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005207 +name: obsolete extracellular matrix glycoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes localization and modification rather than activity. +synonym: "extracellular matrix glycoprotein" EXACT [] +is_obsolete: true +consider: GO:0005201 + +[Term] +id: GO:0005208 +name: obsolete amyloid protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "amyloid protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005209 +name: obsolete plasma protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes presence in body fluids rather than an activity. +synonym: "plasma protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005211 +name: obsolete plasma glycoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. +synonym: "plasma glycoprotein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005212 +name: structural constituent of eye lens +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005213 +name: structural constituent of egg chorion +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of an egg chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] +synonym: "structural constituent of chorion" BROAD [] +synonym: "structural protein of chorion" NARROW [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0005214 +name: structural constituent of chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0042302 ! structural constituent of cuticle + +[Term] +id: GO:0005215 +name: transporter activity +namespace: molecular_function +alt_id: GO:0005478 +def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] +comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. +subset: gocheck_do_not_annotate +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +synonym: "carrier" RELATED [] +xref: EC:7.-.-.- +xref: Reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" +xref: Reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005216 +name: ion channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0015267 ! channel activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0005217 +name: intracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0005219 +name: ryanodine-sensitive calcium-release channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] +synonym: "caffeine-sensitive calcium-release channel" RELATED [] +synonym: "ryanodine receptor" NARROW [] +xref: Reactome:R-HSA-2855020 "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol" +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0005220 +name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +namespace: molecular_function +alt_id: GO:0008095 +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor] +synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT [] +synonym: "InsP3 receptor" EXACT [GOC:bf] +synonym: "IP3 receptor activity" EXACT [] +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0005221 +name: intracellular cyclic nucleotide activated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +xref: Reactome:R-HSA-2514867 "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment" +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0005222 +name: intracellular cAMP-activated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +synonym: "HCN channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "hyperpolarization-activated cyclic nucleotide-gated channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] +synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] +synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] +synonym: "intracellular cAMP activated cation channel activity" EXACT [] +synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] +is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity + +[Term] +id: GO:0005223 +name: intracellular cGMP-activated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] +synonym: "intracellular cGMP activated cation channel activity" EXACT [] +is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity + +[Term] +id: GO:0005225 +name: volume-sensitive anion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb] +synonym: "volume-regulated channel" BROAD [] +xref: Reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region" +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0005227 +name: calcium activated cation channel activity +namespace: molecular_function +def: "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] +synonym: "intracellular calcium-activated potassium channel" NARROW [] +synonym: "polycystin" NARROW [] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0005228 +name: intracellular sodium activated potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0005229 +name: intracellular calcium activated chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +xref: Reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region" +xref: Reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region" +xref: Reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region" +xref: Reactome:R-HSA-9659568 "ANO1 transports cytosolic Cl- to extracellular region" +is_a: GO:0022839 ! ion gated channel activity +is_a: GO:0061778 ! intracellular chloride channel activity + +[Term] +id: GO:0005230 +name: extracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0005231 +name: excitatory extracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070] +xref: Reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors" +xref: Reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors" +xref: Reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors" +xref: Reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell" +xref: Reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors" +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005234 +name: extracellularly glutamate-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. +synonym: "extracellular-glutamate-gated ion channel activity" EXACT [] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005237 +name: inhibitory extracellular ligand-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070] +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0005240 +name: obsolete glycine receptor-associated protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not describe a molecular function. +synonym: "glycine receptor-associated protein" EXACT [] +is_obsolete: true +consider: GO:0005515 + +[Term] +id: GO:0005241 +name: obsolete inward rectifier channel +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "inward rectifier channel" EXACT [] +is_obsolete: true +consider: GO:0005242 + +[Term] +id: GO:0005242 +name: inward rectifier potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] +synonym: "Kir channel activity" EXACT [GOC:cb] +xref: Reactome:R-HSA-1296045 "Activation of Potassium transport channels" +xref: Reactome:R-HSA-1296046 "KCNJs transport K+ from the extracellular region to cytosol" +xref: Reactome:R-HSA-1369017 "Activation of ATP sensitive Potassium channels in muscle cells" +xref: Reactome:R-HSA-5678261 "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5678418 "Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol" +is_a: GO:0005249 ! voltage-gated potassium channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0005243 +name: gap junction channel activity +namespace: molecular_function +alt_id: GO:0015285 +alt_id: GO:0015286 +def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] +synonym: "connexin" RELATED [] +synonym: "innexin" NARROW [] +synonym: "innexin channel activity" EXACT [] +synonym: "intercellular channel" BROAD [] +xref: Reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane" +xref: Reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication" +xref: Reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication" +xref: Reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication" +xref: Reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication" +is_a: GO:0022829 ! wide pore channel activity + +[Term] +id: GO:0005244 +name: voltage-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "voltage gated ion channel activity" EXACT [] +synonym: "voltage-dependent ion channel activity" EXACT [] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022832 ! voltage-gated channel activity + +[Term] +id: GO:0005245 +name: voltage-gated calcium channel activity +namespace: molecular_function +alt_id: GO:0010173 +alt_id: GO:0015270 +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] +synonym: "depolarization-activated calcium channel" BROAD [] +synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] +synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] +synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] +synonym: "dihydropyridine-sensitive calcium channel activity" NARROW [] +synonym: "voltage gated calcium channel activity" EXACT [] +synonym: "voltage-dependent calcium channel activity" EXACT [] +synonym: "voltage-gated calcium ion channel activity" EXACT [] +synonym: "voltage-sensitive calcium channel" EXACT [] +xref: Reactome:R-HSA-265645 "Calcium Influx through Voltage-gated Calcium Channels" +xref: Reactome:R-HSA-5577213 "LTCC multimer transports Ca2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-9701055 "TRPA1 tetramer transports Ca2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-9701141 "TRPV1 transports Ca2+ from extracellular region to cytosol" +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0005246 +name: calcium channel regulator activity +namespace: molecular_function +def: "Modulates the activity of a calcium channel." [GOC:mah] +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0005247 +name: voltage-gated chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +synonym: "voltage gated chloride channel activity" EXACT [] +synonym: "voltage-dependent chloride channel activity" EXACT [] +xref: Reactome:R-HSA-2744228 "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0008308 ! voltage-gated anion channel activity + +[Term] +id: GO:0005248 +name: voltage-gated sodium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +synonym: "voltage gated sodium channel activity" EXACT [] +synonym: "voltage-dependent sodium channel activity" EXACT [] +synonym: "voltage-gated sodium ion channel activity" EXACT [] +synonym: "voltage-sensitive sodium channel" EXACT [] +xref: Reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol" +is_a: GO:0005272 ! sodium channel activity + +[Term] +id: GO:0005249 +name: voltage-gated potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +synonym: "voltage gated potassium channel activity" EXACT [] +synonym: "voltage-dependent potassium channel activity" EXACT [] +synonym: "voltage-gated potassium ion channel activity" EXACT [] +synonym: "voltage-sensitive potassium channel" EXACT [] +xref: Reactome:R-HSA-1296127 "Activation of voltage gated Potassium channels" +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0005250 +name: A-type (transient outward) potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] +xref: Reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region" +is_a: GO:0015271 ! outward rectifier potassium channel activity + +[Term] +id: GO:0005251 +name: delayed rectifier potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] +xref: Reactome:R-HSA-5577050 "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region" +xref: Reactome:R-HSA-5577237 "KCNH2:KCNE transport K+ from cytosol to extracellular region" +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0005252 +name: open rectifier potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578] +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0005253 +name: anion channel activity +namespace: molecular_function +def: "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] +synonym: "non-selective anion channel activity" NARROW [] +xref: Reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles" +xref: Reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles" +is_a: GO:0005216 ! ion channel activity +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0005254 +name: chloride channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] +xref: Reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region" +xref: Reactome:R-HSA-427570 "Group 3 - Selective Cl- transport" +xref: Reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol" +xref: Reactome:R-HSA-975449 "GABRR pentamers:GABA transports extracellular Cl- to cytosol" +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0005260 +name: intracellularly ATP-gated chloride channel activity +namespace: molecular_function +alt_id: GO:0005224 +def: "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:24727426, PMID:9922375] +synonym: "ATP phosphohydrolase (channel-conductance-controlling)" RELATED [EC:5.6.1.6] +synonym: "ATP-binding and phosphorylation-dependent chloride channel activity" EXACT [] +synonym: "channel-conductance-controlling ATPase activity" EXACT [] +synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] +synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:5.6.1.6] +xref: EC:5.6.1.6 +xref: MetaCyc:3.6.3.49-RXN +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0099095 ! ligand-gated anion channel activity +is_a: GO:0099142 ! intracellularly ATP-gated ion channel activity + +[Term] +id: GO:0005261 +name: cation channel activity +namespace: molecular_function +alt_id: GO:0015281 +alt_id: GO:0015338 +def: "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] +synonym: "cation diffusion facilitator activity" EXACT [] +synonym: "non-selective cation channel activity" NARROW [] +xref: Reactome:R-HSA-1168376 "STIM1 oligomerizes" +xref: Reactome:R-HSA-1296043 "Activation of HCN channels" +xref: Reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol" +xref: Reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol" +xref: Reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7" +xref: Reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT" +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0005262 +name: calcium channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] +xref: Reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol" +xref: Reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma" +xref: Reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels" +xref: Reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol" +xref: Reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space" +xref: Reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix" +is_a: GO:0005261 ! cation channel activity +is_a: GO:0015085 ! calcium ion transmembrane transporter activity + +[Term] +id: GO:0005267 +name: potassium channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] +xref: Reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells" +xref: Reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermediate conductance" +xref: Reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance" +xref: Reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance" +xref: Reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)" +xref: Reactome:R-HSA-1299297 "Activation of THIK" +xref: Reactome:R-HSA-1299304 "Activation of tandem pore domain in a weak inwardly rectifying K+ channels" +xref: Reactome:R-HSA-1299318 "Activation of TASK" +xref: Reactome:R-HSA-1299338 "Activation of TRESK" +xref: Reactome:R-HSA-1299359 "Activation of TALK" +xref: Reactome:R-HSA-2534365 "Slo3 Potassium Transport" +xref: Reactome:R-HSA-5578910 "KCNK dimers transport K+ from cytosol to extracellular region" +is_a: GO:0005261 ! cation channel activity +is_a: GO:0015079 ! potassium ion transmembrane transporter activity + +[Term] +id: GO:0005272 +name: sodium channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] +xref: Reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol" +xref: Reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol" +is_a: GO:0005261 ! cation channel activity +is_a: GO:0015081 ! sodium ion transmembrane transporter activity + +[Term] +id: GO:0005274 +name: allantoin:proton symporter activity +namespace: molecular_function +alt_id: GO:0015206 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] +synonym: "allantoin permease activity" RELATED [] +synonym: "allantoin uptake transmembrane transporter activity" NARROW [] +synonym: "allantoin/allantoate transporter" BROAD [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0005275 +name: amine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005279 +def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "amine/amide/polyamine channel activity" BROAD [] +synonym: "amine/polyamine transmembrane transporter activity" EXACT [] +synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0005276 +name: obsolete vesicular amino acid:proton antiporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625] +comment: The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions +synonym: "hydrogen:vesicular amine antiporter activity" EXACT [] +synonym: "vesicular hydrogen:amino acid antiporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005277 +name: acetylcholine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +xref: Reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicles" +is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:1901375 ! acetate ester transmembrane transporter activity + +[Term] +id: GO:0005278 +name: acetylcholine:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] +synonym: "acetylcholine:hydrogen antiporter activity" EXACT [] +is_a: GO:0005277 ! acetylcholine transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0005280 +name: amino acid:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] +synonym: "cation/amino acid symporter" BROAD [] +synonym: "hydrogen:amino acid symporter activity" EXACT [] +xref: Reactome:R-HSA-8875623 "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix" +is_a: GO:0005416 ! amino acid:cation symporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0005281 +name: obsolete general amino acid permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "general amino acid permease activity" EXACT [] +synonym: "general amino acid transporter" BROAD [] +is_obsolete: true +replaced_by: GO:0015171 + +[Term] +id: GO:0005283 +name: amino acid:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005284 +alt_id: GO:0005285 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "insulin-activated sodium/amino acid transporter activity" NARROW [] +synonym: "insulin-activated sodium:amino acid symporter activity" NARROW [] +synonym: "insulin-activated sodium:amino acid transporter activity" NARROW [] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "sodium/amino acid transporter activity" BROAD [] +synonym: "sodium/excitatory amino acid cotransporter activity" BROAD [] +synonym: "sodium/excitatory amino acid symporter activity" EXACT [] +synonym: "sodium:amino acid symporter activity" EXACT [] +synonym: "sodium:amino acid transporter activity" BROAD [] +synonym: "threonine/serine:sodium symporter activity" NARROW [] +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0005416 ! amino acid:cation symporter activity + +[Term] +id: GO:0005287 +name: high-affinity basic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity basic amino acid transmembrane transporter activity" EXACT [] +synonym: "high-affinity basic amino acid transporter activity" BROAD [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity + +[Term] +id: GO:0005289 +name: high-affinity L-arginine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity arginine transmembrane transporter activity" EXACT [] +synonym: "high-affinity arginine transmembrane transporter activity" EXACT [] +synonym: "high-affinity arginine transporter activity" BROAD [] +is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity +is_a: GO:0061459 ! L-arginine transmembrane transporter activity + +[Term] +id: GO:0005290 +name: L-histidine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-histidine transporter activity" BROAD [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:0005291 +name: high-affinity L-histidine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity histidine permease activity" RELATED [] +synonym: "high affinity L-histidine transmembrane transporter activity" EXACT [] +is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity +is_a: GO:0005290 ! L-histidine transmembrane transporter activity + +[Term] +id: GO:0005292 +name: high-affinity lysine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity lysine transmembrane transporter activity" EXACT [] +synonym: "high affinity lysine transporter activity" BROAD [] +is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity +is_a: GO:0015189 ! L-lysine transmembrane transporter activity + +[Term] +id: GO:0005294 +name: neutral L-amino acid secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "neutral L-amino acid porter activity" RELATED [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0005295 +name: neutral amino acid:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005282 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] +synonym: "neutral amino acid-sodium cotransporter" BROAD [] +synonym: "sodium/neutral amino acid transporter" BROAD [] +is_a: GO:0005283 ! amino acid:sodium symporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0005297 +name: proline:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] +synonym: "hydrogen/proline transporter" BROAD [] +is_a: GO:0005280 ! amino acid:proton symporter activity + +[Term] +id: GO:0005298 +name: proline:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] +synonym: "sodium/proline symporter activity" EXACT [] +xref: Reactome:R-HSA-444100 "PROT mediates L-proline uptake" +xref: RHEA:28967 +is_a: GO:0005283 ! amino acid:sodium symporter activity + +[Term] +id: GO:0005300 +name: high-affinity tryptophan transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] +synonym: "high-affinity tryptophan transporter activity" BROAD [] +is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity + +[Term] +id: GO:0005301 +name: obsolete valine/tyrosine/tryptophan permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] +synonym: "valine/tyrosine/tryptophan permease activity" EXACT [] +is_obsolete: true +consider: GO:0005302 +consider: GO:0005304 +consider: GO:0015196 +consider: GO:0022857 + +[Term] +id: GO:0005302 +name: L-tyrosine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015508 +def: "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-tyrosine permease activity" EXACT [] +synonym: "L-tyrosine transporter activity" BROAD [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005304 +name: L-valine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "L-valine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity + +[Term] +id: GO:0005307 +name: choline:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] +synonym: "sodium/choline symporter activity" EXACT [] +is_a: GO:0015220 ! choline transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005308 +name: creatine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0005309 +name: creatine:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] +synonym: "sodium/chloride-dependent creatine transporter" BROAD [] +xref: Reactome:R-HSA-200396 "Creatine transport across the plasma membrane" +is_a: GO:0005308 ! creatine transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005310 +name: dicarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005312 +alt_id: GO:0015365 +def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] +synonym: "dicarboxylate carrier" NARROW [] +synonym: "dicarboxylic acid permease activity" RELATED [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +xref: Reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" +xref: Reactome:R-HSA-372843 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0005311 +name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" EXACT [] +is_obsolete: true +consider: GO:0005310 +consider: GO:0005343 +consider: GO:0015142 + +[Term] +id: GO:0005313 +name: L-glutamate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "glutamate/aspartate porter activity" NARROW [] +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "L-glutamate transporter activity" BROAD [] +xref: Reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" +xref: Reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" +xref: Reactome:R-HSA-5624256 "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0005314 +name: high-affinity glutamate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] +synonym: "high-affinity glutamate transporter activity" BROAD [] +xref: Reactome:R-HSA-210404 "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+" +xref: Reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5625015 "Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5625029 "SLC1A1 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" +is_a: GO:0005313 ! L-glutamate transmembrane transporter activity +is_a: GO:0015501 ! glutamate:sodium symporter activity + +[Term] +id: GO:0005315 +name: inorganic phosphate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005317 +def: "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0005316 +name: high-affinity inorganic phosphate:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2] +synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT [] +synonym: "sodium/phosphate cotransporter activity" BROAD [] +is_a: GO:0005436 ! sodium:phosphate symporter activity + +[Term] +id: GO:0005318 +name: obsolete phosphate:hydrogen symporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +synonym: "phosphate:hydrogen symporter" EXACT [] +synonym: "phosphate:proton symporter activity" EXACT [] +is_obsolete: true +consider: GO:0015317 + +[Term] +id: GO:0005319 +name: lipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] +synonym: "apolipoprotein" RELATED [] +synonym: "lipophorin" NARROW [] +xref: Reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" +xref: Reactome:R-HSA-1369052 "ABCAs mediate lipid influx" +xref: Reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" +xref: Reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5682311 "Defective ABCA12 does not transport lipids from cytosol to extracellular region" +xref: Reactome:R-HSA-5683672 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-5688397 "Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body" +xref: Reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" +xref: Reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0005320 +name: obsolete apolipoprotein +namespace: molecular_function +alt_id: GO:0015907 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "apolipoprotein" EXACT [] +is_obsolete: true +consider: GO:0005319 + +[Term] +id: GO:0005321 +name: obsolete high-density lipoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "HDL" EXACT [] +synonym: "high-density lipoprotein" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005322 +name: obsolete low-density lipoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "LDL" EXACT [] +synonym: "low-density lipoprotein" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005323 +name: obsolete very-low-density lipoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "very-low-density lipoprotein" EXACT [] +synonym: "VLDL" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0005324 +name: long-chain fatty acid transporter activity +namespace: molecular_function +alt_id: GO:0005325 +alt_id: GO:0008562 +def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [ISBN:0198506732] +xref: Reactome:R-HSA-2046087 "Translocation of tetracosahexaenoyl-CoA to peroxisomes" +xref: Reactome:R-HSA-2046093 "Translocation of tetracosapentaenoyl-CoA to peroxisomes" +xref: Reactome:R-HSA-382575 "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix" +xref: Reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA" +xref: Reactome:R-HSA-434381 "CD36 (FAT) translocates palmitate from the extracellular region to the cytosol" +xref: Reactome:R-HSA-5684043 "Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix" +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0005326 +name: neurotransmitter transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] +synonym: "neurotransmitter transporter activity" RELATED [] +xref: Reactome:R-HSA-374896 "Uptake of Noradrenaline" +xref: Reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0005328 +name: neurotransmitter:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] +synonym: "sodium/neurotransmitter symporter activity" EXACT [] +is_a: GO:0005326 ! neurotransmitter transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005330 +name: dopamine:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005329 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.3] +synonym: "dopamine transmembrane transporter activity" EXACT [] +synonym: "dopamine:sodium:chloride symporter activity" EXACT [] +synonym: "sodium/dopamine symporter activity" EXACT [] +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015378 ! sodium:chloride symporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0005332 +name: gamma-aminobutyric acid:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] +comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. +synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] +synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] +synonym: "betaine/GABA:sodium symporter activity" EXACT [] +synonym: "GABA:sodium symporter activity" EXACT [] +synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] +xref: Reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport" +is_a: GO:0005283 ! amino acid:sodium symporter activity +is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity +is_a: GO:0140161 ! monocarboxylate:sodium symporter activity + +[Term] +id: GO:0005334 +name: norepinephrine:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005333 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.2] +synonym: "levarterenol transporter activity" EXACT [] +synonym: "noradrenaline transporter activity" EXACT [] +synonym: "norepinephrine transmembrane transporter activity" EXACT [] +synonym: "norepinephrine:sodium:chloride symporter activity" EXACT [] +synonym: "sodium/norepinephrine symporter activity" EXACT [] +xref: Reactome:R-HSA-443997 "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5659764 "Defective SLC6A2 does not cotransport NAd, Na+ from extracellular region to cytosol" +xref: Wikipedia:Norepinephrine_transporter +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015378 ! sodium:chloride symporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0005335 +name: serotonin:sodium symporter activity +namespace: molecular_function +alt_id: GO:0005336 +alt_id: GO:0015222 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.1] +synonym: "serotonin transmembrane transporter activity" EXACT [] +synonym: "serotonin:sodium:chloride symporter activity" EXACT [] +synonym: "sodium/serotonin symporter activity" EXACT [] +xref: Reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol" +xref: RHEA:51196 +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015378 ! sodium:chloride symporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0005337 +name: nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] +synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] +xref: Reactome:R-HSA-109527 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" +xref: Reactome:R-HSA-109529 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" +xref: Reactome:R-HSA-109534 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" +xref: Reactome:R-HSA-109536 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" +xref: Reactome:R-HSA-5628807 "Defective SLC29A3 does not transport nucleosides from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" +xref: Reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen" +xref: Reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" +is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0005338 +name: nucleotide-sugar transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005339 +def: "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] +xref: Reactome:R-HSA-744230 "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP" +xref: Reactome:R-HSA-744231 "SLC35D2 exchanges UDP-sugars for UMP" +is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0005340 +name: nucleotide-sulfate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005341 +def: "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] +synonym: "nucleotide-sulphate transporter activity" EXACT [] +is_a: GO:0015116 ! sulfate transmembrane transporter activity +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0005342 +name: organic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0005343 +name: organic acid:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] +synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +xref: Reactome:R-HSA-8876312 "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol" +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005344 +name: oxygen carrier activity +namespace: molecular_function +alt_id: GO:0015033 +def: "Binding to oxygen and delivering it to an acceptor molecule or a specific location." [GOC:ai] +synonym: "globin" NARROW [] +synonym: "hemerythrin" NARROW [] +synonym: "hemocyanin" NARROW [] +synonym: "oxygen-carrying" NARROW [] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0005345 +name: purine nucleobase transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732] +synonym: "purine base transmembrane transporter activity" EXACT [GOC:go_curators] +synonym: "purine transmembrane transporter activity" RELATED [] +is_a: GO:0015205 ! nucleobase transmembrane transporter activity + +[Term] +id: GO:0005346 +name: purine ribonucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0005347 +name: ATP transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005348 +def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0005350 +name: pyrimidine nucleobase transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai] +synonym: "pyrimidine base transmembrane transporter activity" EXACT [GOC:go_curators] +synonym: "pyrimidine transmembrane transporter activity" RELATED [] +is_a: GO:0015205 ! nucleobase transmembrane transporter activity + +[Term] +id: GO:0005351 +name: carbohydrate:proton symporter activity +namespace: molecular_function +alt_id: GO:0005403 +alt_id: GO:0015542 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in)." [TC:2.A.1.1] +synonym: "cation/sugar symporter activity" NARROW [] +synonym: "hydrogen:sugar symporter activity" NARROW [] +synonym: "hydrogen:sugar transporter activity" BROAD [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +synonym: "proton:sugar symporter activity" EXACT [] +synonym: "sugar efflux transmembrane transporter activity" NARROW [PMID:20971900] +synonym: "sugar porter activity" NARROW [] +synonym: "sugar transporter" BROAD [] +synonym: "sugar:hydrogen ion symporter activity" NARROW [] +synonym: "sugar:hydrogen symporter activity" EXACT [] +synonym: "sugar:proton symporter activity" NARROW [] +xref: TC:2.A.1.1 +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0005352 +name: alpha-glucoside:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] +synonym: "alpha-glucoside:hydrogen symporter activity" EXACT [] +synonym: "general alpha-glucoside transporter activity" BROAD [] +synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] +synonym: "general alpha-glucoside:proton symporter activity" EXACT [] +is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0005353 +name: fructose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015585 +alt_id: GO:0019192 +def: "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "fructose permease activity" EXACT [] +synonym: "fructose porter activity" EXACT [] +xref: Reactome:R-HSA-189222 "SLC2A5 transports fructose from extracellular region to cytosol" +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005354 +name: galactose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005355 +name: glucose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015579 +def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] +synonym: "glucose permease activity" EXACT [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +xref: Reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" +xref: Reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0005356 +name: glucose:proton symporter activity +namespace: molecular_function +alt_id: GO:0005361 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "hydrogen:glucose symporter activity" EXACT [] +synonym: "hydrogen:glucose transporter activity" RELATED [] +synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] +synonym: "transepithelial hydrogen:glucose symporter activity" NARROW [] +synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0009679 ! hexose:proton symporter activity + +[Term] +id: GO:0005357 +name: obsolete constitutive glucose:proton symporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +comment: The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter. +synonym: "constitutive hydrogen/glucose transporter activity" BROAD [] +synonym: "constitutive hydrogen:glucose symporter activity" EXACT [] +synonym: "constitutive hydrogen:glucose transporter activity" BROAD [] +is_obsolete: true + +[Term] +id: GO:0005358 +name: high-affinity glucose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high-affinity hydrogen/glucose transporter activity" BROAD [] +synonym: "high-affinity hydrogen:glucose symporter activity" EXACT [] +synonym: "high-affinity hydrogen:glucose transporter activity" BROAD [] +is_a: GO:0005356 ! glucose:proton symporter activity + +[Term] +id: GO:0005359 +name: low-affinity glucose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "low-affinity hydrogen/glucose transporter activity" BROAD [] +synonym: "low-affinity hydrogen:glucose symporter activity" EXACT [] +synonym: "low-affinity hydrogen:glucose transporter activity" BROAD [] +is_a: GO:0005356 ! glucose:proton symporter activity + +[Term] +id: GO:0005360 +name: insulin-responsive glucose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] +synonym: "insulin-responsive hydrogen:glucose symporter activity" EXACT [] +synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] +synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] +is_a: GO:0005356 ! glucose:proton symporter activity + +[Term] +id: GO:0005362 +name: low-affinity glucose:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] +synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] +xref: Reactome:R-HSA-429567 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4" +is_a: GO:0005412 ! glucose:sodium symporter activity + +[Term] +id: GO:0005363 +name: maltose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015581 +def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "maltose porter activity" EXACT [] +xref: RHEA:33171 +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0005364 +name: maltose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] +synonym: "hydrogen/maltose transporter activity" BROAD [] +synonym: "maltose permease" BROAD [] +synonym: "maltose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0005363 ! maltose transmembrane transporter activity + +[Term] +id: GO:0005365 +name: myo-inositol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] +synonym: "vitamin Bh transporter activity" EXACT [] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0005366 +name: myo-inositol:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] +synonym: "hydrogen/myo-inositol transporter activity" BROAD [] +synonym: "myo-inositol:hydrogen symporter activity" EXACT [] +xref: Reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton" +xref: RHEA:60364 +is_a: GO:0005365 ! myo-inositol transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0005367 +name: myo-inositol:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] +synonym: "myo-inositol-sodium cotransporter activity" BROAD [] +xref: Reactome:R-HSA-429663 "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol" +is_a: GO:0005365 ! myo-inositol transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005368 +name: taurine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0042959 ! alkanesulfonate transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0005369 +name: taurine:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] +synonym: "sodium/chloride-dependent taurine transporter" BROAD [] +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0005368 ! taurine transmembrane transporter activity + +[Term] +id: GO:0005371 +name: tricarboxylate secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005370 +def: "Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0815340729] +synonym: "tricarboxylate carrier activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0005372 +name: water transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of water (H2O) from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0005373 +name: obsolete heavy metal ion porter activity +namespace: molecular_function +def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "heavy metal ion porter activity" EXACT [] +synonym: "metal ion transporter" BROAD [] +is_obsolete: true +consider: GO:0015291 +consider: GO:0046873 + +[Term] +id: GO:0005375 +name: copper ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005378 +alt_id: GO:0005379 +alt_id: GO:0005380 +alt_id: GO:0015088 +def: "Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] +synonym: "copper uptake transmembrane transporter activity" RELATED [] +synonym: "intracellular copper ion transporter" NARROW [] +synonym: "plasma membrane copper transporter" NARROW [] +xref: Reactome:R-HSA-437300 "SLC31A1 transports Cu2+ from extracellular region to cytosol" +xref: RHEA:28703 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005376 +name: obsolete plasma membrane copper transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "plasma membrane copper transporter" EXACT [] +is_obsolete: true +consider: GO:0005375 +consider: GO:0005886 + +[Term] +id: GO:0005377 +name: obsolete intracellular copper ion transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "intracellular copper ion transporter" EXACT [] +synonym: "intracellular copper transporter" EXACT [] +is_obsolete: true +consider: GO:0005375 +consider: GO:0005622 + +[Term] +id: GO:0005381 +name: iron ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005382 +alt_id: GO:0016033 +alt_id: GO:0097689 +def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] +comment: An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell. +synonym: "iron cation channel activity" EXACT [] +synonym: "iron channel activity" EXACT [] +synonym: "iron transporter activity" EXACT [] +synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] +synonym: "transmembrane iron ion permease activity" EXACT [] +synonym: "transmembrane iron permease activity" EXACT [] +synonym: "zinc, iron permease activity" RELATED [] +xref: Reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5623558 "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5655733 "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region" +xref: Reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" +xref: Reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005384 +name: manganese ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf] +xref: Reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region" +xref: RHEA:28699 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005385 +name: zinc ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf] +synonym: "cobalt, zinc uptake permease activity" RELATED [] +synonym: "zinc, cadmium uptake permease activity" RELATED [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] +synonym: "zinc, iron permease activity" NARROW [] +xref: Reactome:R-HSA-435366 "ZnT1 mediates the efflux of zinc from the cell" +xref: Reactome:R-HSA-435375 "ZnT2 facilitates zinc vesicular sequestration" +xref: Reactome:R-HSA-437084 "ZnT3 transports zinc into synaptic vesicles" +xref: Reactome:R-HSA-437085 "ZnT5 transports zinc into secretory granules in pancreatic beta cells" +xref: Reactome:R-HSA-437129 "ZnT7 transports zinc into the golgi apparatus" +xref: Reactome:R-HSA-437136 "SLC30A8 transports Zn2+ from cytosol to secretory granule" +xref: Reactome:R-HSA-437139 "ZnT6 transports zinc into the golgi apparatus" +xref: Reactome:R-HSA-442317 "ZIP6 and ZIP14 mediate zinc influx into cells" +xref: Reactome:R-HSA-442345 "hZIP10 mediates zinc influx into cells" +xref: Reactome:R-HSA-442387 "ZIP8 mediates zinc influx into cells" +xref: Reactome:R-HSA-442393 "ZIP7 mediates zinc efflux from the endoplasmic reticulum" +xref: Reactome:R-HSA-442405 "hZIP5 mediates zinc uptake by cells" +xref: Reactome:R-HSA-442422 "SLC39A1-4 transports Zn2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5654125 "Defective SLC39A4 does not transport Zn2+ from extracellular region to cytosol" +xref: RHEA:29351 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0005388 +name: P-type calcium transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out)." [RHEA:18105] +synonym: "ATP-dependent calcium transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled calcium transmembrane transporter activity" RELATED [] +synonym: "Ca(2+)-transporting ATPase activity" RELATED [EC:7.2.2.10] +synonym: "Ca2+-transporting ATPase activity" RELATED [EC:7.2.2.10] +synonym: "calcium efflux ATPase" NARROW [] +synonym: "calcium pump" BROAD [] +synonym: "calcium transmembrane transporter activity, phosphorylative mechanism" EXACT [] +synonym: "calcium transporting ATPase activity" EXACT [] +synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:7.2.2.10] +synonym: "calcium-transporting ATPase activity" EXACT [] +synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [] +xref: EC:7.2.2.10 +xref: MetaCyc:3.6.3.8-RXN +xref: Reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region" +xref: Reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen" +xref: Reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen" +xref: Reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" +xref: RHEA:18105 +is_a: GO:0015085 ! calcium ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0005391 +name: P-type sodium:potassium-exchanging transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:7.2.2.13] +synonym: "Na(+)/K(+)-ATPase activity" RELATED [EC:7.2.2.13] +synonym: "Na(+)/K(+)-exchanging ATPase activity" RELATED [EC:7.2.2.13] +synonym: "Na+,K+-ATPase activity" RELATED [EC:7.2.2.13] +synonym: "Na+/K+-ATPase activity" RELATED [EC:7.2.2.13] +synonym: "Na+/K+-exchanging ATPase activity" RELATED [EC:7.2.2.13] +synonym: "Na,K-activated ATPase activity" RELATED [EC:7.2.2.13] +synonym: "P-type sodium:potassium-exchanging ATPase activity" EXACT [] +synonym: "sodium pump" BROAD [EC:7.2.2.13] +synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] +synonym: "sodium/potassium-transporting ATPase activity" EXACT [] +synonym: "sodium:potassium exchanging ATPase activity" EXACT [] +synonym: "sodium:potassium-exchanging ATPase activity" EXACT [] +xref: EC:7.2.2.13 +xref: MetaCyc:3.6.3.9-RXN +xref: Reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+" +xref: RHEA:18353 +xref: TC:3.A.3.1.1 +xref: Wikipedia:ATPase\,_Na%2B/K%2B_transporting\,_alpha_1 +is_a: GO:0008554 ! P-type sodium transporter activity +is_a: GO:0008556 ! P-type potassium transmembrane transporter activity + +[Term] +id: GO:0005395 +name: obsolete eye pigment precursor transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] +comment: This term has been obsoleted because eye pigment precursors are nucleotides and amino acids, and there are terms to annotate these functions. +is_obsolete: true + +[Term] +id: GO:0005396 +name: obsolete transmembrane conductance regulator activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. +synonym: "transmembrane conductance regulator activity" EXACT [] +is_obsolete: true +consider: GO:0043267 + +[Term] +id: GO:0005400 +name: obsolete peroxisomal membrane transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "peroxisomal membrane transporter" EXACT [] +is_obsolete: true +consider: GO:0005215 +consider: GO:0005777 + +[Term] +id: GO:0005402 +name: carbohydrate:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] +synonym: "cation/sugar symporter activity" EXACT [] +synonym: "cation:sugar symporter activity" EXACT [] +synonym: "sugar:cation symporter activity" NARROW [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0005412 +name: glucose:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] +synonym: "sodium/glucose symporter activity" EXACT [] +xref: Reactome:R-HSA-189208 "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol" +xref: Reactome:R-HSA-429613 "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5656356 "Defective SLC5A1 does not cotransport Glc and Na+" +xref: Reactome:R-HSA-5658163 "Defective SLC5A2 does not cotransport Glc and Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-8932955 "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol" +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005415 +name: nucleoside:sodium symporter activity +namespace: molecular_function +alt_id: GO:0008522 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] +synonym: "nucleoside-sodium cotransporter activity" BROAD [] +synonym: "sodium-dependent nucleoside transporter activity" BROAD [] +xref: Reactome:R-HSA-109530 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1" +xref: Reactome:R-HSA-109538 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3" +xref: Reactome:R-HSA-109539 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2" +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005416 +name: amino acid:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] +synonym: "cation/amino acid symporter activity" EXACT [] +synonym: "cation:amino acid symporter activity" EXACT [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0005427 +name: proton-dependent oligopeptide secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] +synonym: "hydrogen/oligopeptide symporter" RELATED [] +synonym: "proton-dependent oligopeptide transporter activity" EXACT [] +is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity + +[Term] +id: GO:0005429 +name: obsolete chromaffin granule amine transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of amines across chromaffin granule membranes." [GOC:mah] +comment: The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion. +is_obsolete: true + +[Term] +id: GO:0005430 +name: obsolete synaptic vesicle amine transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes." [GOC:ai] +comment: The class was obsoleted because the cellular location of a function should not be part of the class label. +is_obsolete: true +consider: GO:0005275 + +[Term] +id: GO:0005432 +name: calcium:sodium antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] +synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] +synonym: "sodium/calcium exchanger" EXACT [] +synonym: "sodium:calcium exchange" RELATED [] +xref: Reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+" +xref: Reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" +xref: Reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)" +xref: RHEA:29255 +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015368 ! calcium:cation antiporter activity + +[Term] +id: GO:0005436 +name: sodium:phosphate symporter activity +namespace: molecular_function +alt_id: GO:0015321 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] +synonym: "sodium-dependent phosphate transmembrane transporter activity" RELATED [] +synonym: "sodium/phosphate symporter activity" EXACT [] +xref: Reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol" +xref: Reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+" +xref: Reactome:R-HSA-427656 "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport" +xref: Reactome:R-HSA-5625123 "Defective SLC20A2 does not cotransport Pi, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5651685 "Defective SLC34A1 does not cotransport Pi, 3Na+" +xref: Reactome:R-HSA-5651697 "Defective SLC34A2 does not cotransport Pi, 3Na+" +xref: Reactome:R-HSA-5651971 "Defective SLC34A3 does not cotransport Pi, 2Na+" +xref: Reactome:R-HSA-5687585 "Defective SLC34A2 does not cotransport HPO4(2-), 3Na+ from extracellular region to cytosol" +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0005451 +name: monovalent cation:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] +synonym: "monovalent cation:hydrogen antiporter activity" EXACT [] +xref: Reactome:R-HSA-2889070 "SLC9B2 exchanges Na+, Li+ for H+" +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0005452 +name: inorganic anion exchanger activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] +xref: Reactome:R-HSA-1237038 "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-" +xref: Reactome:R-HSA-1247665 "Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate" +xref: Reactome:R-HSA-425482 "SLC4A1,2,3 exchanges HCO3- for Cl-" +xref: Reactome:R-HSA-425577 "Na+-driven Cl-/HCO3- exchanger transport" +xref: Reactome:R-HSA-427666 "SLC26A3,6 exchange Cl- for HCO3-" +xref: Reactome:R-HSA-5627737 "SLC26A3 does not exchange Cl- for HCO3-" +xref: Reactome:R-HSA-5656248 "Defective SLC4A1 does not exchange Cl- for HCO3- (in erythrocytes)" +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0005456 +name: CMP-N-acetylneuraminate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "CMP-sialic acid transmembrane transporter activity" BROAD [] +xref: Reactome:R-HSA-5651942 "Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP" +xref: Reactome:R-HSA-727807 "SLC35A1 exchanges CMP-Neu5Ac for CMP" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005457 +name: GDP-fucose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-5653596 "Defective SLC35C1 does not transport UDP-Fuc from cytosol to Golgi lumen" +xref: Reactome:R-HSA-742345 "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen" +is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005458 +name: GDP-mannose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005459 +name: UDP-galactose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-5652099 "Defective SLC35A2 does not exchange UDP-Gal, UDP-GalNAc for UMP" +xref: Reactome:R-HSA-735702 "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP" +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005460 +name: UDP-glucose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005461 +name: UDP-glucuronic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-174368 "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen" +xref: Reactome:R-HSA-5603297 "Defective SLC35D1 does not transport UDP-GlcA, UDPGlcNAc" +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005462 +name: UDP-N-acetylglucosamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-5653622 "Defective SLC35A3 does not exchange UDP-GlcNAc for UMP" +xref: Reactome:R-HSA-741450 "SLC35A3 exchanges UDP-GlcNAc for UMP" +xref: Reactome:R-HSA-742354 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005463 +name: UDP-N-acetylgalactosamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005464 +name: UDP-xylose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] +xref: Reactome:R-HSA-742373 "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0005468 +name: obsolete small-molecule carrier or transporter +namespace: molecular_function +alt_id: GO:0005453 +alt_id: GO:0005454 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not provide a useful functional classification. +synonym: "small-molecule carrier or transporter" EXACT [] +is_obsolete: true +consider: GO:0005215 + +[Term] +id: GO:0005469 +name: succinate:fumarate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] +is_a: GO:0015138 ! fumarate transmembrane transporter activity +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0005471 +name: ATP:ADP antiporter activity +namespace: molecular_function +alt_id: GO:0005349 +def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] +synonym: "adenine nucleotide translocase" EXACT [] +synonym: "ADP/ATP carrier protein" EXACT [] +synonym: "ADP/ATP translocase" EXACT [] +synonym: "ATP/ADP exchange" EXACT [] +synonym: "ATP/ADP exchanger" EXACT [] +is_a: GO:0005347 ! ATP transmembrane transporter activity +is_a: GO:0015217 ! ADP transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0005476 +name: carnitine:acyl carnitine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] +synonym: "carnitine/acyl carnitine carrier activity" EXACT [] +synonym: "carnitine:acyl carnitine carrier activity" EXACT [] +synonym: "fatty acyl carnitine carrier" EXACT [] +is_a: GO:0015226 ! carnitine transmembrane transporter activity +is_a: GO:0015227 ! acyl carnitine transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0005477 +name: pyruvate secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "pyruvate carrier activity" RELATED [] +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0050833 ! pyruvate transmembrane transporter activity + +[Term] +id: GO:0005479 +name: obsolete vacuolar assembly +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +synonym: "vacuolar assembly" EXACT [] +is_obsolete: true +replaced_by: GO:0007033 + +[Term] +id: GO:0005480 +name: obsolete vesicle transport +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +synonym: "vesicle transport" EXACT [] +is_obsolete: true +replaced_by: GO:0016192 + +[Term] +id: GO:0005481 +name: obsolete vesicle fusion +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +synonym: "vesicle fusion" EXACT [] +is_obsolete: true +consider: GO:0006906 +consider: GO:0007086 +consider: GO:0016189 +consider: GO:0016192 +consider: GO:0019817 + +[Term] +id: GO:0005482 +name: obsolete vesicle targeting +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +synonym: "vesicle targeting" EXACT [] +is_obsolete: true +consider: GO:0006903 +consider: GO:0016080 + +[Term] +id: GO:0005483 +name: soluble NSF attachment protein activity +namespace: molecular_function +def: "Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] +synonym: "SNAP" EXACT [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0005484 +name: SNAP receptor activity +namespace: molecular_function +alt_id: GO:0005485 +alt_id: GO:0005486 +def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] +subset: goslim_chembl +synonym: "Q-SNARE activity" NARROW [] +synonym: "R-SNARE activity" NARROW [] +synonym: "SNAP-25" NARROW [] +synonym: "SNARE" EXACT [] +synonym: "t-SNARE activity" NARROW [] +synonym: "v-SNARE activity" NARROW [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0005488 +name: binding +namespace: molecular_function +def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] +comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. +subset: gocheck_do_not_annotate +subset: goslim_pir +subset: goslim_plant +synonym: "ligand" NARROW [] +xref: Wikipedia:Binding_(molecular) +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0005489 +name: obsolete electron transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] +comment: This term was made obsolete because the activity described by the definition does not exist. +synonym: "class I cytochrome c" RELATED [] +synonym: "class II cytochrome c" RELATED [] +synonym: "class IIa cytochrome c" RELATED [] +synonym: "class IIb cytochrome c" RELATED [] +synonym: "class III cytochrome c" RELATED [] +synonym: "class IV cytochrome c" RELATED [] +synonym: "cytochrome b" RELATED [] +synonym: "cytochrome b5" RELATED [] +synonym: "cytochrome c3 (tetraheme)" RELATED [] +synonym: "cytochrome c554" RELATED [] +synonym: "cytochrome c7 (triheme)" RELATED [] +synonym: "cytochrome d" RELATED [] +synonym: "diheme class I cytochrome c" RELATED [] +synonym: "electron transfer carrier" RELATED [] +synonym: "electron transporter activity" EXACT [] +synonym: "flavin-containing electron transporter" RELATED [] +synonym: "flavodoxin" RELATED [] +synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] +synonym: "monoheme class I cytochrome c" RELATED [] +synonym: "nonaheme cytochrome c" RELATED [] +synonym: "respiratory chain cytochrome b6" RELATED [] +synonym: "Rieske iron-sulfur protein" RELATED [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0005490 +name: obsolete cytochrome P450 +namespace: molecular_function +def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] +comment: This term was made obsolete because its definition was changed and because it represents a gene product. +synonym: "cytochrome P450" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005496 +name: steroid binding +namespace: molecular_function +def: "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] +subset: goslim_pir +is_a: GO:0008289 ! lipid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0005497 +name: androgen binding +namespace: molecular_function +def: "Binding to an androgen, a male sex hormone." [GOC:jl] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0005499 +name: vitamin D binding +namespace: molecular_function +def: "Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] +synonym: "calciferol binding" NARROW [] +synonym: "cholecalciferol binding" NARROW [] +synonym: "ergocalciferol binding" NARROW [] +is_a: GO:0005496 ! steroid binding +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0005500 +name: juvenile hormone binding +namespace: molecular_function +def: "Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] +is_a: GO:0019840 ! isoprenoid binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0005501 +name: retinoid binding +namespace: molecular_function +def: "Binding to a retinoid, a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] +xref: Reactome:R-HSA-2454113 "RBP3 transports 11cRAL to rod photoreceptor outer segment" +xref: Reactome:R-HSA-2464809 "RBP3 regulates the transport of atROL from ROS to RPE" +xref: Reactome:R-HSA-2465934 "11cROL translocates from Muller cells to cone photoreceptor cells" +xref: Reactome:R-HSA-2465938 "RBP3 regulates atROL taken up by Muller cells" +is_a: GO:0019840 ! isoprenoid binding + +[Term] +id: GO:0005502 +name: 11-cis retinal binding +namespace: molecular_function +def: "Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [PMID:24403072] +synonym: "11-cis retinaldehyde binding" EXACT [] +synonym: "11-cis-retinal binding" NARROW [] +synonym: "vitamin A binding" BROAD [] +is_a: GO:0016918 ! retinal binding + +[Term] +id: GO:0005503 +name: all-trans retinal binding +namespace: molecular_function +def: "Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [GOC:curators] +synonym: "all-trans retinaldehyde binding" EXACT [] +synonym: "trans retinal binding" EXACT [] +synonym: "visual yellow binding" EXACT [] +synonym: "vitamin A binding" BROAD [] +synonym: "xanthopsin" RELATED [] +is_a: GO:0016918 ! retinal binding + +[Term] +id: GO:0005504 +name: fatty acid binding +namespace: molecular_function +def: "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] +is_a: GO:0008289 ! lipid binding +is_a: GO:0033293 ! monocarboxylic acid binding + +[Term] +id: GO:0005505 +name: obsolete heavy metal binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "heavy metal binding" EXACT [] +is_obsolete: true +consider: GO:0046872 + +[Term] +id: GO:0005506 +name: iron ion binding +namespace: molecular_function +def: "Binding to an iron (Fe) ion." [GOC:ai] +synonym: "iron binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0005507 +name: copper ion binding +namespace: molecular_function +def: "Binding to a copper (Cu) ion." [GOC:ai] +synonym: "copper binding" EXACT [] +synonym: "copper/cadmium binding" BROAD [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0005508 +name: obsolete copper/cadmium binding +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a composite function. +synonym: "copper/cadmium binding" EXACT [] +is_obsolete: true +consider: GO:0005507 +consider: GO:0046870 + +[Term] +id: GO:0005509 +name: calcium ion binding +namespace: molecular_function +def: "Binding to a calcium ion (Ca2+)." [GOC:ai] +synonym: "calcium ion storage activity" RELATED [] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0005513 +name: detection of calcium ion +namespace: biological_process +def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] +synonym: "Ca2+ ion detection" EXACT [] +synonym: "calcium ion detection" EXACT [] +synonym: "calcium ion sensing" EXACT [] +synonym: "detection of Ca2+ ion" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051592 ! response to calcium ion + +[Term] +id: GO:0005514 +name: obsolete calcium ion storage activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +synonym: "calcium ion storage activity" EXACT [] +is_obsolete: true +consider: GO:0005509 +consider: GO:0051208 + +[Term] +id: GO:0005515 +name: protein binding +namespace: molecular_function +alt_id: GO:0001948 +alt_id: GO:0045308 +def: "Binding to a protein." [GOC:go_curators] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "glycoprotein binding" NARROW [] +synonym: "protein amino acid binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0005516 +name: calmodulin binding +namespace: molecular_function +def: "Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] +subset: goslim_chembl +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005517 +name: obsolete calmodulin inhibitor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'. +synonym: "calmodulin inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0005516 + +[Term] +id: GO:0005518 +name: collagen binding +namespace: molecular_function +def: "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0005519 +name: cytoskeletal regulatory protein binding +namespace: molecular_function +def: "Binding to a protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0005520 +name: insulin-like growth factor binding +namespace: molecular_function +def: "Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732] +subset: goslim_chembl +synonym: "IGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0005521 +name: lamin binding +namespace: molecular_function +def: "Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732] +synonym: "lamin/chromatin binding" BROAD [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005522 +name: profilin binding +namespace: molecular_function +def: "Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0005523 +name: tropomyosin binding +namespace: molecular_function +def: "Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0005524 +name: ATP binding +namespace: molecular_function +def: "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] +xref: Reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel" +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0035639 ! purine ribonucleoside triphosphate binding + +[Term] +id: GO:0005525 +name: GTP binding +namespace: molecular_function +def: "Binding to GTP, guanosine triphosphate." [GOC:ai] +xref: Reactome:R-HSA-167429 "The receptor:G-protein complex binds GTP" +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0035639 ! purine ribonucleoside triphosphate binding + +[Term] +id: GO:0005527 +name: macrolide binding +namespace: molecular_function +def: "Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0005528 +name: FK506 binding +namespace: molecular_function +def: "Binding to a 23-membered macrolide lactone FK506." [GOC:jl] +synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] +is_a: GO:0005527 ! macrolide binding +is_a: GO:0033218 ! amide binding + +[Term] +id: GO:0005530 +name: obsolete lectin +namespace: molecular_function +def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "lectin" EXACT [] +is_obsolete: true +consider: GO:0007157 +consider: GO:0030246 + +[Term] +id: GO:0005531 +name: obsolete galactose binding lectin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "galactose binding lectin" EXACT [] +is_obsolete: true +consider: GO:0005534 +consider: GO:0007157 + +[Term] +id: GO:0005532 +name: obsolete mannose binding lectin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "mannose binding lectin" EXACT [] +synonym: "mannose receptor" RELATED [] +is_obsolete: true +consider: GO:0005537 +consider: GO:0007157 + +[Term] +id: GO:0005533 +name: obsolete N-acetylgalactosamine lectin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "N-acetylgalactosamine lectin" EXACT [] +is_obsolete: true +consider: GO:0007157 +consider: GO:0046871 + +[Term] +id: GO:0005534 +name: galactose binding +namespace: molecular_function +def: "Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [GOC:jl, ISBN:0198506732] +synonym: "galactose binding lectin" RELATED [] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005536 +name: glucose binding +namespace: molecular_function +def: "Binding to D- or L-enantiomers of glucose." [GOC:jl] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005537 +name: mannose binding +namespace: molecular_function +def: "Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [GOC:jl, ISBN:0192800981] +subset: goslim_chembl +synonym: "mannose binding lectin" RELATED [] +xref: Reactome:R-HSA-947991 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi" +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0005539 +name: glycosaminoglycan binding +namespace: molecular_function +def: "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0005540 +name: hyaluronic acid binding +namespace: molecular_function +def: "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl] +synonym: "hyaluronan binding" EXACT [] +is_a: GO:0005539 ! glycosaminoglycan binding + +[Term] +id: GO:0005541 +name: obsolete acyl-CoA or acyl binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it was replaced by more appropriate terms. +synonym: "acyl-CoA or acyl binding" EXACT [] +is_obsolete: true +consider: GO:0000035 +consider: GO:0000062 + +[Term] +id: GO:0005542 +name: folic acid binding +namespace: molecular_function +def: "Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732] +synonym: "folate binding" EXACT [] +synonym: "vitamin B9 binding" EXACT [] +synonym: "vitamin M binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0033218 ! amide binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0072341 ! modified amino acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0005543 +name: phospholipid binding +namespace: molecular_function +def: "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0005544 +name: calcium-dependent phospholipid binding +namespace: molecular_function +def: "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0005545 +name: 1-phosphatidylinositol binding +namespace: molecular_function +def: "Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] +is_a: GO:0035091 ! phosphatidylinositol binding + +[Term] +id: GO:0005546 +name: phosphatidylinositol-4,5-bisphosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT [] +synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc] +synonym: "PIP2 binding" BROAD [] +synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf] +is_a: GO:0043168 ! anion binding +is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding + +[Term] +id: GO:0005547 +name: phosphatidylinositol-3,4,5-trisphosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] +synonym: "PIP3 binding" EXACT [GOC:bf] +is_a: GO:0043168 ! anion binding +is_a: GO:1901981 ! phosphatidylinositol phosphate binding + +[Term] +id: GO:0005548 +name: phospholipid transporter activity +namespace: molecular_function +alt_id: GO:0008497 +def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732] +xref: Reactome:R-HSA-216757 "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane" +xref: Reactome:R-HSA-382553 "ABCA7:Apo1A-mediated phospholipid efflux" +xref: Reactome:R-HSA-5678706 "ABCB4 transports PC from plasma membrane to extracellular region" +xref: Reactome:R-HSA-5678749 "Defective ABCB4 does not transport PC from plasma membrane to extracellular region" +xref: Reactome:R-HSA-8857662 "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane" +xref: Reactome:R-HSA-8865637 "MFSD2A transports LPC from extracellular region to plasma membrane" +xref: Reactome:R-HSA-8867876 "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0005549 +name: odorant binding +namespace: molecular_function +def: "Binding to an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0005550 +name: pheromone binding +namespace: molecular_function +def: "Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] +is_a: GO:0005549 ! odorant binding + +[Term] +id: GO:0005551 +name: obsolete ubiquitin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +consider: GO:0016567 +consider: GO:0031386 + +[Term] +id: GO:0005552 +name: obsolete polyubiquitin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "polyubiquitin" EXACT [] +is_obsolete: true +consider: GO:0000209 + +[Term] +id: GO:0005553 +name: obsolete ubiquitin-ribosomal protein fusion protein +namespace: molecular_function +def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732] +comment: This term was made obsolete because it describes a gene product. +synonym: "ubiquitin-ribosomal protein fusion protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005555 +name: obsolete blood group antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "blood group antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005557 +name: obsolete lymphocyte antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "lymphocyte antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005558 +name: obsolete minor histocompatibility antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "minor histocompatibility antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005559 +name: obsolete ribozyme +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "ribozyme" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005561 +name: obsolete nucleic acid +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "nucleic acid" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005562 +name: obsolete RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "RNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005563 +name: obsolete transfer RNA +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "transfer RNA" EXACT [] +is_obsolete: true +replaced_by: GO:0030533 + +[Term] +id: GO:0005564 +name: obsolete cytosolic tRNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "cytosolic tRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005565 +name: obsolete mitochondrial tRNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "mitochondrial tRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005566 +name: obsolete ribosomal RNA +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "ribosomal RNA" EXACT [] +is_obsolete: true +consider: GO:0003735 +consider: GO:0005840 + +[Term] +id: GO:0005567 +name: obsolete cytosolic ribosomal RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "cytosolic ribosomal RNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005568 +name: obsolete mitochondrial rRNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "mitochondrial rRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005569 +name: obsolete small nucleolar RNA +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents gene products. +synonym: "small nucleolar RNA" EXACT [] +is_obsolete: true +consider: GO:0030555 + +[Term] +id: GO:0005570 +name: obsolete small nuclear RNA +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents gene products. +synonym: "small nuclear RNA" EXACT [] +is_obsolete: true +consider: GO:0000375 +consider: GO:0017069 + +[Term] +id: GO:0005571 +name: obsolete untranslated RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "untranslated RNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005572 +name: obsolete RNA polymerase II transcribed untranslated RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "RNA polymerase II transcribed untranslated RNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005573 +name: obsolete telomerase RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a gene product. +synonym: "telomerase RNA" EXACT [] +is_obsolete: true +replaced_by: GO:0000332 + +[Term] +id: GO:0005574 +name: obsolete DNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. +synonym: "DNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005575 +name: cellular_component +namespace: cellular_component +alt_id: GO:0008372 +def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao1337158144] +comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "cell or subcellular entity" EXACT [] +synonym: "cellular component" EXACT [] +synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] +xref: NIF_Subcellular:sao1337158144 + +[Term] +id: GO:0005576 +name: extracellular region +namespace: cellular_component +def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] +comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "extracellular" EXACT [] +xref: Wikipedia:Extracellular +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0005577 +name: fibrinogen complex +namespace: cellular_component +def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] +synonym: "fibrinogen" EXACT [] +synonym: "fibrinogen alpha chain" NARROW [] +synonym: "fibrinogen beta chain" NARROW [] +synonym: "fibrinogen gamma chain" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005579 +name: membrane attack complex +namespace: cellular_component +def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149] +synonym: "MAC" EXACT [] +synonym: "membrane attack complex protein alphaM chain" NARROW [] +synonym: "membrane attack complex protein beta2 chain" NARROW [] +synonym: "TCC" EXACT [] +synonym: "terminal complement complex" EXACT [] +xref: Wikipedia:Complement_membrane_attack_complex +is_a: GO:0046930 ! pore complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005580 +name: obsolete membrane attack complex protein alphaM chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "membrane attack complex protein alphaM chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005579 + +[Term] +id: GO:0005581 +name: collagen trimer +namespace: cellular_component +def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0005582 +name: collagen type XV trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911] +is_a: GO:0098651 ! basement membrane collagen trimer + +[Term] +id: GO:0005583 +name: fibrillar collagen trimer +namespace: cellular_component +def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0098643 ! banded collagen fibril + +[Term] +id: GO:0005584 +name: collagen type I trimer +namespace: cellular_component +def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976] +xref: Wikipedia:Collagen_type_I +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005585 +name: collagen type II trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] +xref: Wikipedia:Collagen_type_II +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005586 +name: collagen type III trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005587 +name: collagen type IV trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] +xref: Wikipedia:Collagen_type_IV +is_a: GO:0098642 ! network-forming collagen trimer +is_a: GO:0098651 ! basement membrane collagen trimer + +[Term] +id: GO:0005588 +name: collagen type V trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005589 +name: collagen type VI trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0098647 ! collagen beaded filament + +[Term] +id: GO:0005590 +name: collagen type VII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976, PMID:19693541] +is_a: GO:0030934 ! anchoring collagen complex +relationship: part_of GO:0098652 ! collagen type VII anchoring fibril + +[Term] +id: GO:0005591 +name: collagen type VIII trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911] +is_a: GO:0005598 ! short-chain collagen trimer +is_a: GO:0030935 ! sheet-forming collagen trimer +is_a: GO:0098651 ! basement membrane collagen trimer + +[Term] +id: GO:0005592 +name: collagen type XI trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:0005593 +name: FACIT collagen trimer +namespace: cellular_component +def: "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911] +comment: The acronym FACIT stands for fibril-associated collagen with interrupted triple helix. +xref: Wikipedia:FACIT_collagen +is_a: GO:0005581 ! collagen trimer + +[Term] +id: GO:0005594 +name: collagen type IX trimer +namespace: cellular_component +def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen trimer + +[Term] +id: GO:0005595 +name: collagen type XII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen trimer +is_a: GO:0030934 ! anchoring collagen complex + +[Term] +id: GO:0005596 +name: collagen type XIV trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] +is_a: GO:0005593 ! FACIT collagen trimer +is_a: GO:0030934 ! anchoring collagen complex + +[Term] +id: GO:0005597 +name: collagen type XVI trimer +namespace: cellular_component +def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] +is_a: GO:0005593 ! FACIT collagen trimer + +[Term] +id: GO:0005598 +name: short-chain collagen trimer +namespace: cellular_component +def: "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587] +is_a: GO:0005581 ! collagen trimer + +[Term] +id: GO:0005599 +name: collagen type X trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911] +comment: Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541). +is_a: GO:0005598 ! short-chain collagen trimer +is_a: GO:0030935 ! sheet-forming collagen trimer + +[Term] +id: GO:0005600 +name: collagen type XIII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bhm, GOC:dos, ISBN:0721639976] +is_a: GO:0030936 ! transmembrane collagen trimer + +[Term] +id: GO:0005601 +name: classical-complement-pathway C3/C5 convertase complex +namespace: cellular_component +def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005602 +name: complement component C1 complex +namespace: cellular_component +def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149] +synonym: "complement component C1q complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005603 +name: obsolete complement component C2 complex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex". +synonym: "complement component C2 complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005604 +name: basement membrane +namespace: cellular_component +alt_id: GO:0005605 +alt_id: GO:0008003 +def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934] +comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. +synonym: "basal lamina" RELATED [] +synonym: "basement lamina" RELATED [] +synonym: "lamina densa" RELATED [] +xref: Wikipedia:Basement_membrane +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0005606 +name: laminin-1 complex +namespace: cellular_component +def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-111 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005607 +name: laminin-2 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-211 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005608 +name: laminin-3 complex +namespace: cellular_component +def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] +synonym: "laminin-121 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005609 +name: laminin-4 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-221 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005610 +name: laminin-5 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-332 complex" NARROW [GOC:dph, PMID:15979864] +synonym: "laminin-3A32 complex" EXACT [PMID:15979864] +synonym: "laminin-5A complex" EXACT [PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005611 +name: laminin-6 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-311 complex" EXACT [GOC:dph, PMID:15979864] +synonym: "laminin-6A complex" EXACT [PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005612 +name: laminin-7 complex +namespace: cellular_component +def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-321 complex" NARROW [GOC:dph, PMID:15979864] +synonym: "laminin-7A" EXACT [PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0005613 +name: obsolete laminin receptor protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. +synonym: "laminin receptor protein" EXACT [] +is_obsolete: true +consider: GO:0008305 + +[Term] +id: GO:0005614 +name: interstitial matrix +namespace: cellular_component +def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0005615 +name: extracellular space +namespace: cellular_component +def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] +comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +synonym: "intercellular space" RELATED [] +xref: NIF_Subcellular:sao1425028079 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0005616 +name: larval serum protein complex +namespace: cellular_component +def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0005617 +name: obsolete larval serum protein-1 +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "larval serum protein-1" EXACT [] +synonym: "LSP1" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005618 +name: cell wall +namespace: cellular_component +def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, ISBN:0198547684, PMID:15134259, Wikipedia:Microbial_cyst] +comment: Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for \nplants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995). +subset: gocheck_do_not_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: Wikipedia:Cell_wall +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0005619 +name: ascospore wall +namespace: cellular_component +def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] +synonym: "fungal-type spore wall" BROAD [GOC:mah] +is_a: GO:0009277 ! fungal-type cell wall +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0005621 +name: cellular bud scar +namespace: cellular_component +def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0005622 +name: intracellular anatomical structure +namespace: cellular_component +def: "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] +subset: gocheck_do_not_annotate +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_plant +synonym: "internal to cell" EXACT [] +synonym: "intracellular" EXACT [] +synonym: "nucleocytoplasm" RELATED [GOC:mah] +synonym: "protoplasm" EXACT [] +synonym: "protoplast" RELATED [GOC:mah] +xref: Wikipedia:Intracellular +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0005623 +name: obsolete cell +namespace: cellular_component +def: "OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] +comment: This term was obsoleted because it was redundant with the root class of the cell ontology, CL:0000000. +xref: NIF_Subcellular:sao1813327414 +xref: Wikipedia:Cell_(biology) +is_obsolete: true + +[Term] +id: GO:0005624 +name: obsolete membrane fraction +namespace: cellular_component +def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "membrane fraction" EXACT [] +is_obsolete: true +consider: GO:0016020 + +[Term] +id: GO:0005625 +name: obsolete soluble fraction +namespace: cellular_component +def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "soluble" BROAD [] +synonym: "soluble fraction" EXACT [] +is_obsolete: true +consider: GO:0005575 + +[Term] +id: GO:0005626 +name: obsolete insoluble fraction +namespace: cellular_component +def: "OBSOLETE. That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "insoluble fraction" EXACT [] +synonym: "particle-bound" RELATED [] +is_obsolete: true +consider: GO:0005575 + +[Term] +id: GO:0005627 +name: obsolete ascus +namespace: cellular_component +def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] +comment: This term was made obsolete because it is a structure that contains cell (ascospores) rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. +synonym: "ascus" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005628 +name: prospore membrane +namespace: cellular_component +def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] +synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] +synonym: "forespore membrane" RELATED [] +synonym: "FSM" EXACT [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0005630 +name: dityrosine layer of spore wall +namespace: cellular_component +def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005619 ! ascospore wall + +[Term] +id: GO:0005631 +name: chitosan layer of spore wall +namespace: cellular_component +def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005619 ! ascospore wall + +[Term] +id: GO:0005632 +name: inner layer of spore wall +namespace: cellular_component +def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005619 ! ascospore wall + +[Term] +id: GO:0005633 +name: ascus lipid droplet +namespace: cellular_component +def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] +synonym: "ascus lipid particle" EXACT [] +is_a: GO:0005811 ! lipid droplet + +[Term] +id: GO:0005634 +name: nucleus +namespace: cellular_component +def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "cell nucleus" EXACT [] +synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] +xref: NIF_Subcellular:sao1702920020 +xref: Wikipedia:Cell_nucleus +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0005635 +name: nuclear envelope +namespace: cellular_component +alt_id: GO:0005636 +def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_plant +xref: Wikipedia:Nuclear_envelope +is_a: GO:0031967 ! organelle envelope +relationship: part_of GO:0005634 ! nucleus +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005637 +name: nuclear inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] +synonym: "inner envelope" BROAD [] +synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627] +synonym: "nucleus inner membrane" EXACT [] +xref: NIF_Subcellular:sao1612527463 +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0031965 ! nuclear membrane + +[Term] +id: GO:0005638 +name: lamin filament +namespace: cellular_component +def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] +synonym: "type V intermediate filament" EXACT [] +is_a: GO:0005882 ! intermediate filament +relationship: part_of GO:0005652 ! nuclear lamina + +[Term] +id: GO:0005639 +name: integral component of nuclear inner membrane +namespace: cellular_component +def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] +synonym: "integral to nuclear inner membrane" NARROW [] +is_a: GO:0031229 ! intrinsic component of nuclear inner membrane +is_a: GO:0031301 ! integral component of organelle membrane + +[Term] +id: GO:0005640 +name: nuclear outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] +synonym: "nucleus outer envelope" EXACT [] +synonym: "perinuclear membrane" EXACT [] +xref: NIF_Subcellular:sao1617136075 +is_a: GO:0031965 ! nuclear membrane +is_a: GO:0031968 ! organelle outer membrane +relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network + +[Term] +id: GO:0005641 +name: nuclear envelope lumen +namespace: cellular_component +alt_id: GO:0005653 +def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] +comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. +synonym: "nuclear intermembrane space" EXACT [] +synonym: "nuclear membrane lumen" RELATED [] +synonym: "perinuclear space" EXACT [] +is_a: GO:0031970 ! organelle envelope lumen +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0005642 +name: annulate lamellae +namespace: cellular_component +def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network + +[Term] +id: GO:0005643 +name: nuclear pore +namespace: cellular_component +alt_id: GO:0005644 +def: "A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] +subset: goslim_pir +synonym: "NPC" EXACT [] +synonym: "nuclear pore complex" EXACT [] +synonym: "nuclear pore membrane protein" NARROW [] +synonym: "nucleopore" EXACT [GOC:al, PMID:7603572] +xref: NIF_Subcellular:sao220861693 +xref: Wikipedia:Nuclear_pore +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0005645 +name: obsolete RAN-binding protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "RAN-binding protein" EXACT [] +is_obsolete: true +replaced_by: GO:0031267 + +[Term] +id: GO:0005646 +name: obsolete importin +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "importin" EXACT [] +synonym: "karyopherin" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 +consider: GO:0017056 + +[Term] +id: GO:0005647 +name: obsolete importin, alpha-subunit +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "importin, alpha-subunit" EXACT [] +synonym: "karyopherin-alpha" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 +consider: GO:0017056 + +[Term] +id: GO:0005648 +name: obsolete importin, beta-subunit +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "importin, beta-subunit" EXACT [] +synonym: "karyopherin-beta1" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 +consider: GO:0017056 + +[Term] +id: GO:0005649 +name: obsolete transportin +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "karyopherin-beta2" EXACT [] +synonym: "transportin" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005650 +name: obsolete importin, alpha-subunit transport factor +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "CAS" RELATED [] +synonym: "importin, alpha-subunit transport factor" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 + +[Term] +id: GO:0005651 +name: obsolete exportin +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "exportin" EXACT [] +is_obsolete: true +consider: GO:0005634 +consider: GO:0005643 +consider: GO:0005737 +consider: GO:0017056 + +[Term] +id: GO:0005652 +name: nuclear lamina +namespace: cellular_component +def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] +xref: NIF_Subcellular:sao1455996588 +xref: Wikipedia:Nuclear_lamina +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0034399 ! nuclear periphery + +[Term] +id: GO:0005654 +name: nucleoplasm +namespace: cellular_component +def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_plant +xref: NIF_Subcellular:sao661522542 +xref: Wikipedia:Nucleoplasm +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0005655 +name: nucleolar ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] +synonym: "nucleolar RNase P complex" EXACT [] +is_a: GO:0030681 ! multimeric ribonuclease P complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0005656 +name: nuclear pre-replicative complex +namespace: cellular_component +def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] +synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2] +synonym: "pre-RC" RELATED [] +synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2] +is_a: GO:0036387 ! pre-replicative complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0005657 +name: replication fork +namespace: cellular_component +def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] +synonym: "replication focus" RELATED [] +xref: Wikipedia:Replication_fork +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0005658 +name: alpha DNA polymerase:primase complex +namespace: cellular_component +def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402, PMID:26975377] +synonym: "DNA polymerase alpha:primase complex" EXACT [] +synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] +synonym: "pol-prim" RELATED [] +synonym: "primosome" BROAD [] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0005660 +name: obsolete delta-DNA polymerase cofactor complex +namespace: cellular_component +def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl] +comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. +synonym: "delta DNA polymerase cofactor complex" EXACT [] +synonym: "delta-DNA polymerase cofactor complex" EXACT [] +is_obsolete: true +consider: GO:0005663 +consider: GO:0043626 + +[Term] +id: GO:0005662 +name: DNA replication factor A complex +namespace: cellular_component +def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] +synonym: "replication protein A" EXACT [] +synonym: "RPA" EXACT [] +xref: Wikipedia:Replication_protein_A +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0005663 +name: DNA replication factor C complex +namespace: cellular_component +def: "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520] +subset: goslim_pir +synonym: "activator 1 complex" EXACT [] +synonym: "RFC complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005657 ! replication fork + +[Term] +id: GO:0005664 +name: nuclear origin of replication recognition complex +namespace: cellular_component +def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] +synonym: "eukaryotic ORC" EXACT [] +synonym: "nuclear ORC" EXACT [] +is_a: GO:0000808 ! origin recognition complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0005665 +name: RNA polymerase II, core complex +namespace: cellular_component +def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "DNA-directed RNA polymerase II, core complex" EXACT [] +synonym: "RNA polymerase II complex" BROAD [] +synonym: "RNAP II complex" BROAD [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005666 +name: RNA polymerase III complex +namespace: cellular_component +def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "DNA-directed RNA polymerase III activity" RELATED [] +synonym: "DNA-directed RNA polymerase III complex" EXACT [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex + +[Term] +id: GO:0005667 +name: transcription regulator complex +namespace: cellular_component +alt_id: GO:0044797 +alt_id: GO:0044798 +def: "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] +subset: goslim_pir +synonym: "cytoplasmic transcription factor complex" RELATED [] +synonym: "nuclear transcription factor complex" RELATED [] +synonym: "transcription factor complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0005668 +name: RNA polymerase transcription factor SL1 complex +namespace: cellular_component +def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654] +synonym: "selectivity factor SL1 complex" EXACT [GOC:mah] +synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654] +is_a: GO:0000120 ! RNA polymerase I transcription regulator complex + +[Term] +id: GO:0005669 +name: transcription factor TFIID complex +namespace: cellular_component +def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005670 +name: obsolete transcription-activating factor, 30kD +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "transcription-activating factor, 30kD" EXACT [] +is_obsolete: true +replaced_by: GO:0005669 + +[Term] +id: GO:0005671 +name: obsolete Ada2/Gcn5/Ada3 transcription activator complex +namespace: cellular_component +alt_id: GO:0002928 +def: "OBSOLETE. A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] +comment: This term was obsoleted because it was incorrectly annotated. Consider ADA complex ; GO:0140671 or ATAC complex; GO:0140672. +synonym: "ATAC complex" RELATED [GOC:rl, PMID:18838386] +is_obsolete: true +consider: GO:0140671 +consider: GO:0140672 + +[Term] +id: GO:0005672 +name: transcription factor TFIIA complex +namespace: cellular_component +def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005673 +name: transcription factor TFIIE complex +namespace: cellular_component +def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005674 +name: transcription factor TFIIF complex +namespace: cellular_component +def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005675 +name: transcription factor TFIIH holo complex +namespace: cellular_component +def: "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] +synonym: "holo TFIIH complex" EXACT [] +is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0005677 +name: chromatin silencing complex +namespace: cellular_component +def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0005678 +name: obsolete chromatin assembly complex +namespace: cellular_component +def: "OBSOLETE. Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] +comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. +synonym: "chromatin assembly complex" EXACT [] +synonym: "nucleosome assembly complex" NARROW [] +is_obsolete: true +consider: GO:0031497 + +[Term] +id: GO:0005680 +name: anaphase-promoting complex +namespace: cellular_component +def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] +comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. +synonym: "anaphase promoting complex" EXACT [] +synonym: "APC" BROAD [] +synonym: "cyclosome" EXACT [] +xref: Wikipedia:Anaphase-promoting_complex +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0005681 +name: spliceosomal complex +namespace: cellular_component +def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] +subset: goslim_pir +synonym: "spliceosome" BROAD [] +synonym: "spliceosome complex" EXACT [] +xref: Wikipedia:Spliceosome +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0005682 +name: U5 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U5" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005683 +name: U7 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] +synonym: "snRNP U7" EXACT [GOC:mah] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex + +[Term] +id: GO:0005684 +name: U2-type spliceosomal complex +namespace: cellular_component +def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] +comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. +synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] +synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0005685 +name: U1 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U1" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005686 +name: U2 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself. +synonym: "17S U2 snRNP" NARROW [] +synonym: "snRNP U2" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005687 +name: U4 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U4" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005688 +name: U6 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U6" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005689 +name: U12-type spliceosomal complex +namespace: cellular_component +def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] +synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah] +synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah] +synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah] +xref: Wikipedia:Minor_spliceosome +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0005690 +name: U4atac snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U4atac" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005691 +name: U6atac snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U6atac" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005692 +name: U11 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "12S U11 snRNP" NARROW [] +synonym: "snRNP U11" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005693 +name: U12 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897] +synonym: "snRNP U12" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0005694 +name: chromosome +namespace: cellular_component +def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] +comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_yeast +synonym: "chromatid" RELATED [] +synonym: "interphase chromosome" NARROW [] +synonym: "prophase chromosome" NARROW [] +xref: Wikipedia:Chromosome +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005695 +name: obsolete chromatid +namespace: cellular_component +def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732] +comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. +synonym: "chromatid" EXACT [] +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 +consider: GO:0005694 + +[Term] +id: GO:0005696 +name: obsolete telomere +namespace: cellular_component +def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055] +comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. +synonym: "telomere" EXACT [] +is_obsolete: true +consider: GO:0000781 +consider: GO:0000782 + +[Term] +id: GO:0005697 +name: telomerase holoenzyme complex +namespace: cellular_component +def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0005698 +name: obsolete centromere +namespace: cellular_component +def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732] +comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization. +synonym: "centromere" EXACT [] +is_obsolete: true +consider: GO:0000775 + +[Term] +id: GO:0005700 +name: polytene chromosome +namespace: cellular_component +def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] +xref: Wikipedia:Polytene_chromosome +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0005701 +name: polytene chromosome chromocenter +namespace: cellular_component +def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] +synonym: "polytene chromosome chromocentre" EXACT [] +is_a: GO:0010369 ! chromocenter +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005702 +name: polytene chromosome weak point +namespace: cellular_component +def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] +synonym: "constriction" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005703 +name: polytene chromosome puff +namespace: cellular_component +def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005704 +name: polytene chromosome band +namespace: cellular_component +def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005705 +name: polytene chromosome interband +namespace: cellular_component +def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005706 +name: polytene chromosome ectopic fiber +namespace: cellular_component +def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] +synonym: "polytene chromosome ectopic fibre" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005700 ! polytene chromosome + +[Term] +id: GO:0005707 +name: obsolete interphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "interphase chromosome" EXACT [] +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0005708 +name: obsolete mitotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] +comment: This term was made obsolete because it is based on a process. +synonym: "mitotic chromosome" EXACT [] +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 + +[Term] +id: GO:0005709 +name: obsolete prophase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "prophase chromosome" EXACT [] +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0005710 +name: obsolete metaphase chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] +comment: This term was made obsolete because it is based on a temporal division of the cell cycle. +synonym: "metaphase chromosome" EXACT [] +is_obsolete: true +consider: GO:0000793 +consider: GO:0000794 + +[Term] +id: GO:0005711 +name: obsolete meiotic chromosome +namespace: cellular_component +def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] +comment: This term was made obsolete because it is based on a process. +synonym: "meiotic chromosome" EXACT [] +is_obsolete: true +consider: GO:0000794 + +[Term] +id: GO:0005712 +name: chiasma +namespace: cellular_component +def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732] +xref: Wikipedia:Chiasma_(genetics) +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0005713 +name: recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0005714 +name: early recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] +is_a: GO:0005713 ! recombination nodule + +[Term] +id: GO:0005715 +name: late recombination nodule +namespace: cellular_component +def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] +is_a: GO:0005713 ! recombination nodule + +[Term] +id: GO:0005721 +name: pericentric heterochromatin +namespace: cellular_component +alt_id: GO:0002137 +alt_id: GO:0031618 +def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:12019236, PMID:20206496, PMID:22729156, PMID:9413993] +synonym: "centric heterochromatin" EXACT [] +synonym: "centromeric heterochromatin" EXACT [GOC:dph] +synonym: "nuclear centric heterochromatin" NARROW [] +synonym: "nuclear cluster" NARROW [] +synonym: "nuclear pericentric heterochromatin" NARROW [] +is_a: GO:0000792 ! heterochromatin +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0005722 +name: beta-heterochromatin +namespace: cellular_component +def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] +is_a: GO:0005721 ! pericentric heterochromatin +relationship: part_of GO:0005701 ! polytene chromosome chromocenter + +[Term] +id: GO:0005723 +name: alpha-heterochromatin +namespace: cellular_component +def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] +is_a: GO:0005721 ! pericentric heterochromatin +relationship: part_of GO:0005701 ! polytene chromosome chromocenter + +[Term] +id: GO:0005724 +name: obsolete nuclear telomeric heterochromatin +namespace: cellular_component +def: "OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] +comment: This term was obsoleted because there is no heterochromatin at the telomere and the term had been used inconsistently. +is_obsolete: true + +[Term] +id: GO:0005725 +name: intercalary heterochromatin +namespace: cellular_component +def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0005726 +name: perichromatin fibrils +namespace: cellular_component +def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0005727 +name: extrachromosomal circular DNA +namespace: cellular_component +def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] +subset: goslim_metagenomics +is_a: GO:0005622 ! intracellular anatomical structure +relationship: part_of GO:0046821 ! extrachromosomal DNA + +[Term] +id: GO:0005728 +name: extrachromosomal rDNA circle +namespace: cellular_component +def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] +synonym: "extrachromosomal ribosomal DNA circle" EXACT [] +is_a: GO:0005727 ! extrachromosomal circular DNA + +[Term] +id: GO:0005729 +name: 2-micrometer circle DNA +namespace: cellular_component +def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] +is_a: GO:0005727 ! extrachromosomal circular DNA + +[Term] +id: GO:0005730 +name: nucleolus +namespace: cellular_component +def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: NIF_Subcellular:sao1820400233 +xref: Wikipedia:Nucleolus +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0005731 +name: nucleolus organizer region +namespace: cellular_component +def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] +synonym: "NOR" EXACT [] +synonym: "nucleolus organiser region" EXACT [] +synonym: "nucleolus organizer complex" RELATED [] +xref: Wikipedia:Nucleolus_organizer_region +is_a: GO:0030874 ! nucleolar chromatin + +[Term] +id: GO:0005732 +name: sno(s)RNA-containing ribonucleoprotein complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:17284456] +comment: Note that 'nucleolar' in the name acronym 'snoRNA' is part of the RNA family designation 'small nucleolar', and does not reflect the location of the complex. Both box C/D type and box H/ACA RNAs are found in Archaea (where they are referred to as sRNAs) as well as in Eukaryota. In eukaryotes, box H/ACA RNAs are found in both nucleolar-localized snoRNP complexes and in Cajal body-localized scaRNP complexes. +subset: goslim_pir +synonym: "small nucleolar ribonucleoprotein" NARROW [] +synonym: "small nucleolar ribonucleoprotein complex" NARROW [] +synonym: "small ribonucleoprotein" NARROW [] +synonym: "small ribonucleoprotein protein complex" NARROW [] +synonym: "snoRNP" NARROW [] +synonym: "sRNP" NARROW [] +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0005733 +name: obsolete small nucleolar RNA +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "small nucleolar RNA" EXACT [] +synonym: "snoRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005734 +name: obsolete box C + D snoRNP protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "box C + D snoRNP protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005735 +name: obsolete box H + ACA snoRNP protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "box H + ACA snoRNP protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005736 +name: RNA polymerase I complex +namespace: cellular_component +def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] +synonym: "DNA-directed RNA polymerase I activity" RELATED [] +synonym: "DNA-directed RNA polymerase I complex" EXACT [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0005737 +name: cytoplasm +namespace: cellular_component +def: "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] +subset: goslim_candida +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: Wikipedia:Cytoplasm +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0005739 +name: mitochondrion +namespace: cellular_component +def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] +comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "mitochondria" EXACT [] +xref: NIF_Subcellular:sao1860313010 +xref: Wikipedia:Mitochondrion +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005740 +name: mitochondrial envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] +subset: goslim_candida +subset: goslim_yeast +is_a: GO:0031967 ! organelle envelope +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0005741 +name: mitochondrial outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] +synonym: "mitochondrion outer membrane" EXACT [] +synonym: "outer mitochondrial membrane" EXACT [] +synonym: "outer mitochondrion membrane" EXACT [] +xref: NIF_Subcellular:sao1289741256 +xref: Wikipedia:Outer_mitochondrial_membrane +is_a: GO:0031966 ! mitochondrial membrane +is_a: GO:0031968 ! organelle outer membrane + +[Term] +id: GO:0005742 +name: mitochondrial outer membrane translocase complex +namespace: cellular_component +def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] +synonym: "GIP complex" NARROW [PMID:23201437] +synonym: "mitochondrion outer membrane translocase complex" EXACT [] +is_a: GO:0098799 ! outer mitochondrial membrane protein complex + +[Term] +id: GO:0005743 +name: mitochondrial inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] +synonym: "inner mitochondrial membrane" EXACT [] +synonym: "inner mitochondrion membrane" EXACT [] +synonym: "mitochondrion inner membrane" EXACT [] +xref: NIF_Subcellular:sao1371347282 +xref: Wikipedia:Inner_mitochondrial_membrane +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0005744 +name: TIM23 mitochondrial import inner membrane translocase complex +namespace: cellular_component +def: "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:7.4.2.3, PMID:27554484, PMID:8851659] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +subset: goslim_pir +synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] +synonym: "mitochondrial inner membrane presequence translocase complex" EXACT [] +synonym: "mitochondrial inner membrane translocase complex" BROAD [] +synonym: "Tim23 complex" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0005745 +name: m-AAA complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +is_a: GO:1905368 ! peptidase complex +relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane + +[Term] +id: GO:0005746 +name: mitochondrial respirasome +namespace: cellular_component +alt_id: GO:0097249 +def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] +synonym: "mitochondrial electron transport chain" EXACT [] +synonym: "mitochondrial respiratory chain" EXACT [] +synonym: "mitochondrial respiratory chain supercomplex" EXACT [] +synonym: "mitochondrial respiratory supercomplex" EXACT [] +is_a: GO:0070469 ! respirasome +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0005747 +name: mitochondrial respiratory chain complex I +namespace: cellular_component +alt_id: GO:0005748 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] +is_a: GO:0045271 ! respiratory chain complex I +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005746 ! mitochondrial respirasome + +[Term] +id: GO:0005749 +name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) +namespace: cellular_component +alt_id: GO:0008136 +alt_id: GO:0009362 +alt_id: GO:0019738 +alt_id: GO:0030390 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684] +synonym: "mitochondrial fumarate reductase complex" EXACT [] +is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) +is_a: GO:0045283 ! fumarate reductase complex +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005746 ! mitochondrial respirasome + +[Term] +id: GO:0005750 +name: mitochondrial respiratory chain complex III +namespace: cellular_component +alt_id: GO:0015008 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex" EXACT [] +synonym: "mitochondrial coenzyme Q-cytochrome c reductase complex" EXACT [] +synonym: "mitochondrial complex III" EXACT [GOC:mcc] +synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc] +synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc] +synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc] +synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc] +synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc] +is_a: GO:0045275 ! respiratory chain complex III +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005746 ! mitochondrial respirasome + +[Term] +id: GO:0005751 +name: mitochondrial respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0005752 +def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] +is_a: GO:0045277 ! respiratory chain complex IV +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0005746 ! mitochondrial respirasome + +[Term] +id: GO:0005753 +name: mitochondrial proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0016470 +def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] +synonym: "mitochondrial respiratory chain complex V" EXACT [] +is_a: GO:0045259 ! proton-transporting ATP synthase complex +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0005754 +name: mitochondrial proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] +is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) + +[Term] +id: GO:0005755 +name: obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" EXACT [] +is_obsolete: true +consider: GO:0045263 + +[Term] +id: GO:0005756 +name: mitochondrial proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] +is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) + +[Term] +id: GO:0005757 +name: mitochondrial permeability transition pore complex +namespace: cellular_component +def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078] +synonym: "mitochondrial PT pore complex" EXACT [] +synonym: "MPTP complex" EXACT [] +synonym: "PTPC" BROAD [PMID:21760595] +is_a: GO:0046930 ! pore complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0005758 +name: mitochondrial intermembrane space +namespace: cellular_component +alt_id: GO:0031971 +def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] +synonym: "mitochondrial envelope lumen" EXACT [] +synonym: "mitochondrial membrane lumen" RELATED [] +xref: NIF_Subcellular:sao118944228 +is_a: GO:0031970 ! organelle envelope lumen +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0005759 +name: mitochondrial matrix +namespace: cellular_component +alt_id: GO:0031980 +def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] +synonym: "mitochondrial lumen" EXACT [] +synonym: "mitochondrial stroma" NARROW [] +xref: NIF_Subcellular:sao1804523077 +xref: Wikipedia:Mitochondrial_matrix +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0005760 +name: gamma DNA polymerase complex +namespace: cellular_component +def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005761 +name: mitochondrial ribosome +namespace: cellular_component +def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] +synonym: "55S ribosome, mitochondrial" NARROW [] +is_a: GO:0000313 ! organellar ribosome +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005762 +name: mitochondrial large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] +synonym: "39S ribosomal subunit, mitochondrial" NARROW [] +is_a: GO:0000315 ! organellar large ribosomal subunit +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005761 ! mitochondrial ribosome + +[Term] +id: GO:0005763 +name: mitochondrial small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] +synonym: "28S ribosomal subunit, mitochondrial" NARROW [] +synonym: "mitochondrial ribosomal small subunit complex" EXACT [] +synonym: "mitochondrial ribosomal SSU complex" EXACT [] +is_a: GO:0000314 ! organellar small ribosomal subunit +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005761 ! mitochondrial ribosome + +[Term] +id: GO:0005764 +name: lysosome +namespace: cellular_component +def: "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_plant +xref: NIF_Subcellular:sao585356902 +xref: Wikipedia:Lysosome +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0005765 +name: lysosomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] +synonym: "lysosome membrane" EXACT [] +is_a: GO:0098852 ! lytic vacuole membrane +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0005766 +name: primary lysosome +namespace: cellular_component +def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] +xref: NIF_Subcellular:sao1140587416 +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0005767 +name: secondary lysosome +namespace: cellular_component +def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] +xref: NIF_Subcellular:sao1549842807 +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0005768 +name: endosome +namespace: cellular_component +def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +xref: NIF_Subcellular:sao1720343330 +xref: Wikipedia:Endosome +is_a: GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005769 +name: early endosome +namespace: cellular_component +def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] +xref: NIF_Subcellular:nlx_subcell_20090701 +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0005770 +name: late endosome +namespace: cellular_component +def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] +synonym: "prevacuolar compartment" EXACT [] +synonym: "PVC" BROAD [] +xref: NIF_Subcellular:nlx_subcell_20090702 +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0005771 +name: multivesicular body +namespace: cellular_component +def: "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] +synonym: "multivesicular endosome" EXACT [PMID:12122203] +synonym: "MVB" EXACT [] +synonym: "MVE" EXACT [PMID:12122203] +xref: NIF_Subcellular:sao2045955158 +is_a: GO:0005770 ! late endosome + +[Term] +id: GO:0005773 +name: vacuole +namespace: cellular_component +def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "vacuolar carboxypeptidase Y" RELATED [] +xref: Wikipedia:Vacuole +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005774 +name: vacuolar membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005773 ! vacuole + +[Term] +id: GO:0005775 +name: vacuolar lumen +namespace: cellular_component +def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005773 ! vacuole + +[Term] +id: GO:0005776 +name: autophagosome +namespace: cellular_component +def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] +synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] +synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] +xref: NIF_Subcellular:sao8663416959 +is_a: GO:0005773 ! vacuole + +[Term] +id: GO:0005777 +name: peroxisome +namespace: cellular_component +alt_id: GO:0019818 +def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_plant +subset: goslim_yeast +synonym: "peroxisomal" RELATED [] +synonym: "peroxisome vesicle" BROAD [] +xref: NIF_Subcellular:sao499555322 +xref: Wikipedia:Peroxisome +is_a: GO:0042579 ! microbody + +[Term] +id: GO:0005778 +name: peroxisomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] +synonym: "peroxisome membrane" EXACT [] +is_a: GO:0031903 ! microbody membrane +relationship: part_of GO:0005777 ! peroxisome + +[Term] +id: GO:0005779 +name: integral component of peroxisomal membrane +namespace: cellular_component +def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] +synonym: "integral to peroxisomal membrane" NARROW [] +is_a: GO:0031231 ! intrinsic component of peroxisomal membrane +is_a: GO:0031301 ! integral component of organelle membrane + +[Term] +id: GO:0005780 +name: extrinsic component of intraperoxisomal membrane +namespace: cellular_component +def: "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] +synonym: "extrinsic to intraperoxisomal membrane" EXACT [] +synonym: "intra-peroxisomal peripheral membrane" RELATED [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005778 ! peroxisomal membrane + +[Term] +id: GO:0005781 +name: obsolete peroxisome targeting signal receptor complex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. +synonym: "peroxisome targeting signal receptor complex" EXACT [] +is_obsolete: true +consider: GO:0000268 +consider: GO:0006625 + +[Term] +id: GO:0005782 +name: peroxisomal matrix +namespace: cellular_component +alt_id: GO:0031909 +def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] +synonym: "peroxisomal lumen" EXACT [] +is_a: GO:0031907 ! microbody lumen +relationship: part_of GO:0005777 ! peroxisome + +[Term] +id: GO:0005783 +name: endoplasmic reticulum +namespace: cellular_component +def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "ER" EXACT [] +xref: NIF_Subcellular:sao1036339110 +xref: Wikipedia:Endoplasmic_reticulum +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005784 +name: Sec61 translocon complex +namespace: cellular_component +def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647, PMID:32820719, PMID:33960686] +synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah] +is_a: GO:0071256 ! translocon complex + +[Term] +id: GO:0005785 +name: signal recognition particle receptor complex +namespace: cellular_component +def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732] +synonym: "docking protein complex" RELATED [] +synonym: "SR complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0005786 +name: signal recognition particle, endoplasmic reticulum targeting +namespace: cellular_component +alt_id: GO:0005855 +def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] +synonym: "signal sequence receptor complex" EXACT [] +synonym: "SRP" EXACT [] +xref: Wikipedia:Signal_recognition_particle +is_a: GO:0048500 ! signal recognition particle + +[Term] +id: GO:0005787 +name: signal peptidase complex +namespace: cellular_component +def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1905368 ! peptidase complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0005788 +name: endoplasmic reticulum lumen +namespace: cellular_component +alt_id: GO:0016022 +def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] +synonym: "cisternal lumen" EXACT [] +synonym: "endoplasmic reticulum cisterna" EXACT [] +synonym: "ER cisterna" EXACT [] +synonym: "ER lumen" EXACT [] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0005789 +name: endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] +synonym: "ER membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network +relationship: part_of GO:0098827 ! endoplasmic reticulum subcompartment + +[Term] +id: GO:0005790 +name: smooth endoplasmic reticulum +namespace: cellular_component +def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] +synonym: "SER" EXACT [] +synonym: "smooth ER" EXACT [] +xref: NIF_Subcellular:sao710427438 +xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum +is_a: GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0005791 +name: rough endoplasmic reticulum +namespace: cellular_component +def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] +synonym: "RER" EXACT [] +synonym: "rough ER" EXACT [] +xref: NIF_Subcellular:sao1881364067 +xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum +is_a: GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0005792 +name: obsolete microsome +namespace: cellular_component +def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "microsomal membrane" RELATED [] +synonym: "microsome" EXACT [] +xref: Wikipedia:Microsome +is_obsolete: true +consider: GO:0043231 + +[Term] +id: GO:0005793 +name: endoplasmic reticulum-Golgi intermediate compartment +namespace: cellular_component +def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] +synonym: "EGTC" EXACT [] +synonym: "endoplasmic reticulum-Golgi transport container" EXACT [] +synonym: "ER-Golgi intermediate compartment" EXACT [] +synonym: "ER-Golgi transport container" EXACT [] +synonym: "ERGIC" EXACT [] +synonym: "pre-Golgi intermediate compartment" EXACT [] +synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster] +synonym: "VTC" EXACT [] +xref: Wikipedia:Vesicular-tubular_cluster +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005794 +name: Golgi apparatus +namespace: cellular_component +def: "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways." [ISBN:0198506732] +comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "Golgi" BROAD [] +synonym: "Golgi complex" EXACT [] +synonym: "Golgi ribbon" NARROW [] +xref: NIF_Subcellular:sao451912436 +xref: Wikipedia:Golgi_apparatus +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005795 +name: Golgi stack +namespace: cellular_component +alt_id: GO:0016940 +def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] +synonym: "dictyosome" NARROW [] +synonym: "Golgi cisternae" EXACT [] +is_a: GO:0098791 ! Golgi apparatus subcompartment + +[Term] +id: GO:0005796 +name: Golgi lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0005797 +name: Golgi medial cisterna +namespace: cellular_component +def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] +is_a: GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0005798 +name: Golgi-associated vesicle +namespace: cellular_component +def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] +comment: Note that this definition includes vesicles that are transiently associated with the Golgi. +synonym: "Golgi vesicle" RELATED [] +synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] +xref: NIF_Subcellular:sao819927218 +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0005799 +name: obsolete coatomer +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. +synonym: "coatomer" EXACT [] +synonym: "COPI vesicle" RELATED [] +is_obsolete: true +consider: GO:0030126 +consider: GO:0030137 + +[Term] +id: GO:0005800 +name: obsolete COPII vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +synonym: "COPII vesicle" EXACT [] +is_obsolete: true +consider: GO:0030134 + +[Term] +id: GO:0005801 +name: cis-Golgi network +namespace: cellular_component +def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] +comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle. +synonym: "cis face" BROAD [NIF_Subcellular:sao632188024] +synonym: "cis Golgi network" EXACT [] +synonym: "forming face" RELATED [] +synonym: "Golgi cis face" RELATED [] +synonym: "Golgi cis-face" RELATED [] +xref: NIF_Subcellular:sao632188024 +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0005802 +name: trans-Golgi network +namespace: cellular_component +def: "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] +comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part. +synonym: "Golgi trans face" RELATED [] +synonym: "Golgi trans-face" RELATED [] +synonym: "late Golgi" RELATED [GOC:mah] +synonym: "maturing face" RELATED [] +synonym: "TGN" EXACT [] +synonym: "trans face" BROAD [NIF_Subcellular:sao1039242387] +synonym: "trans Golgi network" EXACT [] +xref: NIF_Subcellular:sao9456487 +is_a: GO:0098791 ! Golgi apparatus subcompartment + +[Term] +id: GO:0005803 +name: obsolete secretory vesicle +namespace: cellular_component +def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] +comment: This term was made obsolete because it was being used to describe two different components. +synonym: "secretory vesicle" EXACT [] +synonym: "transition vesicle" NARROW [] +is_obsolete: true +consider: GO:0030133 +consider: GO:0030141 + +[Term] +id: GO:0005804 +name: obsolete secretory vesicle membrane +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its parent was made obsolete. +synonym: "secretory vesicle membrane" EXACT [] +is_obsolete: true +consider: GO:0030658 +consider: GO:0030667 + +[Term] +id: GO:0005805 +name: obsolete ER-Golgi transport vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +synonym: "ER-Golgi transport vesicle" EXACT [] +is_obsolete: true +consider: GO:0030134 + +[Term] +id: GO:0005806 +name: obsolete Golgi-ER transport vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +synonym: "Golgi-ER transport vesicle" EXACT [] +is_obsolete: true +consider: GO:0030142 + +[Term] +id: GO:0005808 +name: obsolete Golgi-plasma membrane transport vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. +synonym: "Golgi-plasma membrane transport vesicle" EXACT [] +is_obsolete: true +consider: GO:0030133 + +[Term] +id: GO:0005809 +name: obsolete Golgi-vacuole transport vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +synonym: "Golgi-vacuole transport vesicle" EXACT [] +is_obsolete: true +consider: GO:0030133 + +[Term] +id: GO:0005810 +name: obsolete endocytotic transport vesicle +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. +synonym: "endocytotic transport vesicle" EXACT [] +is_obsolete: true +replaced_by: GO:0030139 + +[Term] +id: GO:0005811 +name: lipid droplet +namespace: cellular_component +def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] +comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. +subset: goslim_chembl +subset: goslim_generic +synonym: "adiposome" EXACT [] +synonym: "lipid body" EXACT [] +synonym: "lipid particle" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005813 +name: centrosome +namespace: cellular_component +def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] +subset: goslim_pir +xref: Wikipedia:Centrosome +is_a: GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0005814 +name: centriole +namespace: cellular_component +def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] +comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. +synonym: "daughter centriole" NARROW [GOC:cilia] +synonym: "mother centriole" NARROW [GOC:cilia] +xref: NIF_Subcellular:sao95019936 +xref: Wikipedia:Centriole +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0005815 +name: microtubule organizing center +namespace: cellular_component +def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] +subset: goslim_candida +subset: goslim_chembl +subset: goslim_generic +subset: goslim_yeast +synonym: "microtubule organising centre" EXACT [] +synonym: "MTOC" EXACT [] +xref: Wikipedia:Microtubule_organizing_center +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005816 +name: spindle pole body +namespace: cellular_component +def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] +synonym: "SPB" EXACT [GOC:mah] +xref: Wikipedia:Spindle_pole_body +is_a: GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0005817 +name: obsolete centrosomal mitotic factor +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:clt] +comment: This term was made obsolete because it was not defined. +synonym: "centrosomal mitotic factor" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005818 +name: aster +namespace: cellular_component +def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0099080 ! supramolecular complex +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0005819 +name: spindle +namespace: cellular_component +def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] +xref: Wikipedia:Spindle_apparatus +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005821 +name: intermediate layer of spindle pole body +namespace: cellular_component +def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005822 +name: inner plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005823 +name: central plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005824 +name: outer plaque of spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005825 +name: half bridge of spindle pole body +namespace: cellular_component +def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:0005826 +name: actomyosin contractile ring +namespace: cellular_component +alt_id: GO:0030480 +def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606] +synonym: "actomyosin ring" RELATED [] +synonym: "CAR" EXACT [] +synonym: "constriction ring" RELATED [] +synonym: "contractile actomyosin ring" EXACT [] +synonym: "cytokinetic ring" RELATED [] +is_a: GO:0070938 ! contractile ring +relationship: part_of GO:0030864 ! cortical actin cytoskeleton +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0005827 +name: polar microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] +synonym: "pole-to-pole microtubule" EXACT [] +is_a: GO:0005876 ! spindle microtubule +relationship: part_of GO:0000922 ! spindle pole + +[Term] +id: GO:0005828 +name: kinetochore microtubule +namespace: cellular_component +def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] +synonym: "pole-to-kinetochore microtubule" EXACT [] +is_a: GO:0005876 ! spindle microtubule + +[Term] +id: GO:0005829 +name: cytosol +namespace: cellular_component +def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_plant +xref: NIF_Subcellular:sao101633890 +xref: Wikipedia:Cytosol +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005831 +name: steroid hormone aporeceptor complex +namespace: cellular_component +def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005832 +name: chaperonin-containing T-complex +namespace: cellular_component +def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] +synonym: "CCT particle" EXACT [] +synonym: "TriC" EXACT [] +is_a: GO:0101031 ! chaperone complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005833 +name: hemoglobin complex +namespace: cellular_component +def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732] +synonym: "haemoglobin complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005834 +name: heterotrimeric G-protein complex +namespace: cellular_component +def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684] +comment: See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'. +synonym: "heterotrimeric G-protein GTPase activity" RELATED [] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1905360 ! GTPase complex +relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane + +[Term] +id: GO:0005835 +name: fatty acid synthase complex +namespace: cellular_component +alt_id: GO:0031373 +alt_id: GO:0031374 +def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840] +subset: goslim_pir +synonym: "cytosolic FAS complex" EXACT [] +synonym: "cytosolic fatty acid synthase complex" EXACT [] +synonym: "cytosolic type I FAS complex" EXACT [] +synonym: "cytosolic type I fatty acid synthase complex" EXACT [] +synonym: "FAS complex" EXACT [] +synonym: "fatty acid synthetase complex" EXACT [] +synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] +xref: Wikipedia:Fatty_acid_synthetase_complex +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005836 +name: fatty-acyl-CoA synthase complex +namespace: cellular_component +def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] +comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. +synonym: "fatty acyl CoA synthase complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005837 +name: obsolete 26S proteasome +namespace: cellular_component +def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "26S proteasome" EXACT [] +is_obsolete: true +consider: GO:0000502 + +[Term] +id: GO:0005838 +name: proteasome regulatory particle +namespace: cellular_component +def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] +synonym: "19S regulatory particle" NARROW [] +synonym: "modulator complex" RELATED [CORUM:28] +synonym: "PA700 proteasome activator" NARROW [] +synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0005839 +name: proteasome core complex +namespace: cellular_component +alt_id: GO:0000503 +def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] +subset: goslim_metagenomics +synonym: "20S core complex" NARROW [] +synonym: "20S proteasome" NARROW [GOC:cjk] +synonym: "macropain" EXACT [] +synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000502 ! proteasome complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0005840 +name: ribosome +namespace: cellular_component +alt_id: GO:0033279 +def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] +synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] +synonym: "ribosomal RNA" RELATED [] +xref: NIF_Subcellular:sao1429207766 +xref: Wikipedia:Ribosome +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005844 +name: polysome +namespace: cellular_component +def: "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871] +subset: goslim_pir +synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871] +xref: NIF_Subcellular:sao1038025871 +xref: Wikipedia:Polysome +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0005845 +name: mRNA cap binding complex +namespace: cellular_component +def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] +synonym: "mRNA cap complex" RELATED [] +is_a: GO:0034518 ! RNA cap binding complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005846 +name: nuclear cap binding complex +namespace: cellular_component +def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] +comment: Note that this complex can be found in the cytoplasm as well as the nucleus. +synonym: "CBC" RELATED [] +synonym: "mRNA cap binding complex" NARROW [] +synonym: "NCBP-NIP1 complex" NARROW [] +synonym: "snRNA cap binding complex" NARROW [] +is_a: GO:0034518 ! RNA cap binding complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005847 +name: mRNA cleavage and polyadenylation specificity factor complex +namespace: cellular_component +def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] +synonym: "CFII complex" RELATED [] +synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] +synonym: "CPF complex" NARROW [] +synonym: "CPSF complex" NARROW [] +is_a: GO:0005849 ! mRNA cleavage factor complex + +[Term] +id: GO:0005848 +name: mRNA cleavage stimulating factor complex +namespace: cellular_component +def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] +synonym: "cleavage stimulation factor activity" RELATED [] +synonym: "CstF complex" NARROW [] +is_a: GO:0005849 ! mRNA cleavage factor complex + +[Term] +id: GO:0005849 +name: mRNA cleavage factor complex +namespace: cellular_component +def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0005850 +name: eukaryotic translation initiation factor 2 complex +namespace: cellular_component +def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] +synonym: "eIF-2" EXACT [] +synonym: "eIF2" EXACT [GOC:mah] +xref: Wikipedia:EIF-2 +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005851 +name: eukaryotic translation initiation factor 2B complex +namespace: cellular_component +def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] +synonym: "eIF-2B" EXACT [] +synonym: "eif2B" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005852 +name: eukaryotic translation initiation factor 3 complex +namespace: cellular_component +def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] +synonym: "eIF-3" EXACT [] +synonym: "eIF3" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005853 +name: eukaryotic translation elongation factor 1 complex +namespace: cellular_component +def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005854 +name: nascent polypeptide-associated complex +namespace: cellular_component +def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] +synonym: "NAC" EXACT [] +synonym: "NACA" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005856 +name: cytoskeleton +namespace: cellular_component +def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: Wikipedia:Cytoskeleton +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0005858 +name: axonemal dynein complex +namespace: cellular_component +def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194] +synonym: "axonemal dynein heavy chain" NARROW [] +synonym: "axonemal dynein intermediate chain" NARROW [] +synonym: "axonemal dynein intermediate light chain" NARROW [] +synonym: "axonemal dynein light chain" NARROW [] +is_a: GO:0030286 ! dynein complex +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0005859 +name: muscle myosin complex +namespace: cellular_component +def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] +is_a: GO:0016460 ! myosin II complex +relationship: part_of GO:0043292 ! contractile fiber + +[Term] +id: GO:0005861 +name: troponin complex +namespace: cellular_component +def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005865 ! striated muscle thin filament + +[Term] +id: GO:0005862 +name: muscle thin filament tropomyosin +namespace: cellular_component +def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005865 ! striated muscle thin filament + +[Term] +id: GO:0005863 +name: striated muscle myosin thick filament +namespace: cellular_component +def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] +is_a: GO:0032982 ! myosin filament +is_a: GO:0036379 ! myofilament +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0005865 +name: striated muscle thin filament +namespace: cellular_component +def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] +is_a: GO:0036379 ! myofilament +relationship: part_of GO:0015629 ! actin cytoskeleton +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0005868 +name: cytoplasmic dynein complex +namespace: cellular_component +def: "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311] +comment: Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex. +synonym: "cytoplasmic dynein heavy chain" NARROW [] +synonym: "cytoplasmic dynein intermediate chain" NARROW [] +synonym: "cytoplasmic dynein intermediate light chain" NARROW [] +synonym: "cytoplasmic dynein light chain" NARROW [] +is_a: GO:0030286 ! dynein complex + +[Term] +id: GO:0005869 +name: dynactin complex +namespace: cellular_component +def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] +is_a: GO:0005875 ! microtubule associated complex +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005870 +name: actin capping protein of dynactin complex +namespace: cellular_component +def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499] +is_a: GO:0008290 ! F-actin capping protein complex +relationship: part_of GO:0005869 ! dynactin complex + +[Term] +id: GO:0005871 +name: kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0005872 +name: minus-end kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0005873 +name: plus-end kinesin complex +namespace: cellular_component +def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0005874 +name: microtubule +namespace: cellular_component +def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] +subset: goslim_metagenomics +synonym: "microtubuli" EXACT [] +synonym: "microtubulus" EXACT [] +synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] +xref: NIF_Subcellular:sao1846835077 +xref: Wikipedia:Microtubule +is_a: GO:0099513 ! polymeric cytoskeletal fiber +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005875 +name: microtubule associated complex +namespace: cellular_component +def: "Any multimeric complex connected to a microtubule." [GOC:jl] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0005876 +name: spindle microtubule +namespace: cellular_component +def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0005879 +name: axonemal microtubule +namespace: cellular_component +def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] +is_a: GO:0005881 ! cytoplasmic microtubule +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0005880 +name: nuclear microtubule +namespace: cellular_component +def: "Any microtubule in the nucleus of a cell." [GOC:mah] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0005881 +name: cytoplasmic microtubule +namespace: cellular_component +def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] +synonym: "non-spindle-associated astral microtubule" NARROW [] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005882 +name: intermediate filament +namespace: cellular_component +def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] +synonym: "intermediate filament associated protein" RELATED [] +synonym: "type I intermediate filament associated protein" RELATED [] +synonym: "type II intermediate filament associated protein" RELATED [] +xref: FMA:63851 +xref: NIF_Subcellular:sao952483289 +xref: Wikipedia:Intermediate_filament +is_a: GO:0099513 ! polymeric cytoskeletal fiber +relationship: part_of GO:0045111 ! intermediate filament cytoskeleton + +[Term] +id: GO:0005883 +name: neurofilament +namespace: cellular_component +def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194] +synonym: "type IV intermediate filament" EXACT [] +xref: NIF_Subcellular:sao1316272517 +xref: Wikipedia:Neurofilament +is_a: GO:0005882 ! intermediate filament +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005884 +name: actin filament +namespace: cellular_component +def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] +synonym: "microfilament" EXACT [] +xref: FMA:63850 +xref: NIF_Subcellular:sao1588493326 +xref: Wikipedia:Actin +is_a: GO:0099513 ! polymeric cytoskeletal fiber +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005885 +name: Arp2/3 protein complex +namespace: cellular_component +def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0005886 +name: plasma membrane +namespace: cellular_component +alt_id: GO:0005904 +def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_plant +subset: goslim_yeast +synonym: "bacterial inner membrane" NARROW [] +synonym: "cell membrane" EXACT [] +synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] +synonym: "cytoplasmic membrane" EXACT [] +synonym: "inner endospore membrane" NARROW [] +synonym: "juxtamembrane" BROAD [] +synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] +synonym: "plasmalemma" EXACT [] +xref: NIF_Subcellular:sao1663586795 +xref: Wikipedia:Cell_membrane +is_a: GO:0016020 ! membrane +relationship: part_of GO:0071944 ! cell periphery + +[Term] +id: GO:0005887 +name: integral component of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] +synonym: "integral to plasma membrane" NARROW [] +is_a: GO:0016021 ! integral component of membrane +is_a: GO:0031226 ! intrinsic component of plasma membrane + +[Term] +id: GO:0005888 +name: obsolete proteoglycan integral to plasma membrane +namespace: cellular_component +def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] +comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. +synonym: "proteoglycan integral to plasma membrane" EXACT [] +is_obsolete: true +replaced_by: GO:0005887 + +[Term] +id: GO:0005889 +name: potassium:proton exchanging ATPase complex +namespace: cellular_component +def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] +synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] +synonym: "hydrogen:potassium-exchanging ATPase complex" EXACT [] +synonym: "proton pump" BROAD [] +is_a: GO:0090533 ! cation-transporting ATPase complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005890 +name: sodium:potassium-exchanging ATPase complex +namespace: cellular_component +def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732] +synonym: "sodium pump" BROAD [] +synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] +is_a: GO:0090533 ! cation-transporting ATPase complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005891 +name: voltage-gated calcium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] +subset: goslim_pir +synonym: "voltage gated calcium channel complex" EXACT [] +synonym: "voltage-dependent calcium channel complex" EXACT [] +synonym: "voltage-sensitive calcium channel complex" EXACT [] +is_a: GO:0034704 ! calcium channel complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0005892 +name: acetylcholine-gated channel complex +namespace: cellular_component +def: "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462] +synonym: "nicotinic acetylcholine receptor" BROAD [] +synonym: "nicotinic acetylcholine-gated receptor-channel complex" EXACT [GOC:bf] +is_a: GO:0034702 ! ion channel complex +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005893 +name: interleukin-2 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] +synonym: "IL-2 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005894 +name: interleukin-3 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] +synonym: "IL-3 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005895 +name: interleukin-5 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] +synonym: "IL-5 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005896 +name: interleukin-6 receptor complex +namespace: cellular_component +def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] +synonym: "IL-6 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005897 +name: interleukin-9 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] +synonym: "IL-9 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005898 +name: interleukin-13 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879] +synonym: "IL-13 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005899 +name: insulin receptor complex +namespace: cellular_component +def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +is_a: GO:1902911 ! protein kinase complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005900 +name: oncostatin-M receptor complex +namespace: cellular_component +def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0005901 +name: caveola +namespace: cellular_component +alt_id: GO:0016599 +def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198] +synonym: "caveolae" EXACT [] +synonym: "caveolar membrane" RELATED [] +xref: Wikipedia:Caveolae +is_a: GO:0044853 ! plasma membrane raft + +[Term] +id: GO:0005902 +name: microvillus +namespace: cellular_component +def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0815316194] +comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. +subset: goslim_pir +synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] +xref: NIF_Subcellular:sao671419673 +xref: Wikipedia:Microvillus +is_a: GO:0098858 ! actin-based cell projection + +[Term] +id: GO:0005903 +name: brush border +namespace: cellular_component +def: "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] +subset: goslim_pir +xref: Wikipedia:Brush_border +is_a: GO:0098862 ! cluster of actin-based cell projections + +[Term] +id: GO:0005905 +name: clathrin-coated pit +namespace: cellular_component +def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] +synonym: "coated pit" EXACT [GOC:bf] +xref: NIF_Subcellular:sao1969557946 +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0005906 +name: obsolete clathrin adaptor +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. +synonym: "adaptin" RELATED [] +synonym: "clathrin adaptor" EXACT [] +is_obsolete: true +replaced_by: GO:0030119 + +[Term] +id: GO:0005907 +name: obsolete HA1 clathrin adaptor +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. +synonym: "AP1" RELATED [] +synonym: "HA1 clathrin adaptor" EXACT [] +is_obsolete: true +consider: GO:0030121 + +[Term] +id: GO:0005908 +name: obsolete HA2 clathrin adaptor +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. +synonym: "AP2" RELATED [] +synonym: "HA2 clathrin adaptor" EXACT [] +is_obsolete: true +consider: GO:0030122 + +[Term] +id: GO:0005911 +name: cell-cell junction +namespace: cellular_component +def: "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects." [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] +synonym: "cell-cell contact region" BROAD [] +synonym: "cell-cell contact zone" BROAD [] +synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] +xref: NIF_Subcellular:sao1922892319 +is_a: GO:0070161 ! anchoring junction + +[Term] +id: GO:0005912 +name: adherens junction +namespace: cellular_component +alt_id: GO:0005913 +def: "A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules." [GOC:aruk, GOC:bc, GOC:mah, ISBN:0198506732, PMID:17854762, PMID:20571587, PMID:21422226, PMID:28096264] +synonym: "cell-cell adherens junction" EXACT [] +xref: Wikipedia:Adherens_junction +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0005914 +name: spot adherens junction +namespace: cellular_component +def: "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] +synonym: "dense plaque" BROAD [] +synonym: "punctum adherens" EXACT [] +is_a: GO:0005912 ! adherens junction + +[Term] +id: GO:0005915 +name: zonula adherens +namespace: cellular_component +def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] +synonym: "adhesion belt" EXACT [] +synonym: "belt desmosome" EXACT [] +synonym: "intermediate junction" EXACT [] +synonym: "zonula adhaerens" EXACT [] +xref: NIF_Subcellular:sao1400623473 +is_a: GO:0005912 ! adherens junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005916 +name: fascia adherens +namespace: cellular_component +def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:aruk, GOC:bc, GOC:mtg_muscle, PMID:11732910] +xref: Wikipedia:Fascia_adherens +is_a: GO:0005911 ! cell-cell junction +relationship: part_of GO:0014704 ! intercalated disc + +[Term] +id: GO:0005917 +name: nephrocyte diaphragm +namespace: cellular_component +def: "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] +synonym: "nephrocyte junction" RELATED [PMID:8314002] +is_a: GO:0036056 ! filtration diaphragm + +[Term] +id: GO:0005918 +name: septate junction +namespace: cellular_component +def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods." [ISBN:0815332181, PMID:11700298, PMID:12612641, PMID:20795303, PMID:28636800] +synonym: "septate desmosome" RELATED [] +xref: NIF_Subcellular:sao427941916 +is_a: GO:0070160 ! tight junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005919 +name: pleated septate junction +namespace: cellular_component +def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] +synonym: "pleated desmosome" RELATED [] +is_a: GO:0005918 ! septate junction + +[Term] +id: GO:0005920 +name: smooth septate junction +namespace: cellular_component +def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] +synonym: "zonula continua" EXACT [] +is_a: GO:0005918 ! septate junction + +[Term] +id: GO:0005921 +name: gap junction +namespace: cellular_component +def: "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181, PMID:22366062, Wikipedia:Gap_junction] +synonym: "communicating junction" EXACT [] +synonym: "electrical synapse" RELATED [Wikipedia:Gap_junction] +synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] +synonym: "gap junction macula" EXACT [NIF_Subcellular:sao700839054] +synonym: "gap junction plaque" EXACT [NIF_Subcellular:sao700839054] +synonym: "intercellular gap junction channel" RELATED [] +synonym: "macula communicans" EXACT [] +synonym: "zonula communicans" EXACT [] +xref: NIF_Subcellular:sao118541872 +xref: Wikipedia:Gap_junction +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0005922 +name: connexin complex +namespace: cellular_component +def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] +synonym: "connexon" EXACT [GOC:cjm] +synonym: "connexon complex" RELATED [] +xref: NIF_Subcellular:sao445019788 +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005921 ! gap junction + +[Term] +id: GO:0005923 +name: bicellular tight junction +namespace: cellular_component +def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] +synonym: "zonula occludens" EXACT [] +xref: NIF_Subcellular:sao1939999134 +xref: Wikipedia:Tight_junction +is_a: GO:0070160 ! tight junction +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0005924 +name: obsolete cell-substrate adherens junction +namespace: cellular_component +def: "OBSOLETE. An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] +comment: The reason for obsoletion is that, based on the most recent literature, there is no such structure in biology as 'cell-substrate adherens junction'. An 'adherens junction' is always a 'cell-cell junction' (PMIDs: 20571587, 17854762, 21422226, 28096264, 28401269, 26923917). +synonym: "hemi-adherens junction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0005925 +name: focal adhesion +namespace: cellular_component +alt_id: GO:0005926 +alt_id: GO:0008357 +def: "A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ)." [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] +synonym: "adhesion plaque" RELATED [PMID:3332661] +synonym: "connecting hemi-adherens junction" EXACT [] +synonym: "focal contact" EXACT [] +synonym: "HAJ" EXACT [] +synonym: "hemi-adherens junction" EXACT [] +xref: Wikipedia:Focal_adhesion +is_a: GO:0030055 ! cell-substrate junction + +[Term] +id: GO:0005927 +name: muscle tendon junction +namespace: cellular_component +def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] +synonym: "myotendinous junction" EXACT [] +is_a: GO:0030055 ! cell-substrate junction + +[Term] +id: GO:0005928 +name: obsolete apical hemi-adherens junction +namespace: cellular_component +def: "OBSOLETE. A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] +comment: The reason for obsoletion is that this term has not been used for GO annotation at all since 2001 when it was created, it has no children, it is not a part of any subset/slim. +synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah] +synonym: "apical dense plaque" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005929 +name: cilium +namespace: cellular_component +alt_id: GO:0072372 +def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +synonym: "eukaryotic flagellum" EXACT [] +synonym: "flagellum" RELATED [] +synonym: "microtubule-based flagellum" EXACT [] +synonym: "primary cilium" NARROW [] +xref: FMA:67181 +xref: NIF_Subcellular:sao787716553 +xref: Wikipedia:Cilium +is_a: GO:0043227 ! membrane-bounded organelle +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0005930 +name: axoneme +namespace: cellular_component +alt_id: GO:0035085 +alt_id: GO:0035086 +def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. +subset: goslim_pir +synonym: "ciliary axoneme" EXACT [] +synonym: "cilium axoneme" EXACT [] +synonym: "flagellar axoneme" EXACT [] +synonym: "flagellum axoneme" EXACT [] +xref: Wikipedia:Axoneme +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0097014 ! ciliary plasm + +[Term] +id: GO:0005931 +name: axonemal nexin link +namespace: cellular_component +def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [GOC:cilia, GOC:krc, ISBN:0198506732, PMID:21586547, PMID:21728999, PMID:22683354, PMID:9295136] +synonym: "axonemal interdoublet link" EXACT [] +synonym: "nexin complex" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0005933 +name: cellular bud +namespace: cellular_component +def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0005934 +name: cellular bud tip +namespace: cellular_component +def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] +is_a: GO:0030427 ! site of polarized growth +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0005935 +name: cellular bud neck +namespace: cellular_component +def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] +is_a: GO:0030427 ! site of polarized growth +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0005936 +name: obsolete shmoo +namespace: cellular_component +def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] +comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. +synonym: "shmoo" EXACT [] +is_obsolete: true +consider: GO:0001400 +consider: GO:0005937 + +[Term] +id: GO:0005937 +name: mating projection +namespace: cellular_component +def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] +subset: goslim_pir +synonym: "conjugation tube" NARROW [] +synonym: "shmoo" NARROW [] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0005938 +name: cell cortex +namespace: cellular_component +def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_yeast +synonym: "cell periphery" RELATED [] +synonym: "peripheral cytoplasm" RELATED [] +xref: Wikipedia:Cell_cortex +is_a: GO:0005737 ! cytoplasm +relationship: part_of GO:0071944 ! cell periphery + +[Term] +id: GO:0005940 +name: septin ring +namespace: cellular_component +alt_id: GO:0030481 +def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] +xref: Wikipedia:Septin_ring +is_a: GO:0032156 ! septin cytoskeleton +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0005941 +name: obsolete unlocalized protein complex +namespace: cellular_component +def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] +comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. +synonym: "unlocalized protein complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005942 +name: phosphatidylinositol 3-kinase complex +namespace: cellular_component +def: "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] +comment: For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/ +subset: goslim_pir +synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex" EXACT [] +synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575] +synonym: "PI3K complex" EXACT [] +synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429] +synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0019898 ! extrinsic component of membrane + +[Term] +id: GO:0005943 +name: phosphatidylinositol 3-kinase complex, class IA +namespace: cellular_component +alt_id: GO:0035030 +def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] +synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] +synonym: "class IA PI3K complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] +is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I + +[Term] +id: GO:0005944 +name: phosphatidylinositol 3-kinase complex, class IB +namespace: cellular_component +alt_id: GO:0035031 +def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] +synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex" EXACT [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] +synonym: "class IB PI3K complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] +is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I + +[Term] +id: GO:0005945 +name: 6-phosphofructokinase complex +namespace: cellular_component +def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005946 +name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) +namespace: cellular_component +def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] +comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. +synonym: "trehalose-6-phosphate synthase complex" EXACT [] +synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] +synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005947 +name: mitochondrial alpha-ketoglutarate dehydrogenase complex +namespace: cellular_component +def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] +synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex + +[Term] +id: GO:0005948 +name: acetolactate synthase complex +namespace: cellular_component +def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689] +comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. +synonym: "acetohydroxyacid synthase complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005949 +name: obsolete aminoadipate-semialdehyde dehydrogenase complex +namespace: cellular_component +def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31] +comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. +synonym: "aminoadipate-semialdehyde dehydrogenase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0005950 +name: anthranilate synthase complex +namespace: cellular_component +def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005951 +name: carbamoyl-phosphate synthase complex +namespace: cellular_component +def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] +comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. +synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] +synonym: "carbamoyl phosphate synthase complex" EXACT [] +synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005952 +name: cAMP-dependent protein kinase complex +namespace: cellular_component +def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] +synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] +synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] +synonym: "PKA" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005953 +name: CAAX-protein geranylgeranyltransferase complex +namespace: cellular_component +def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0005954 +name: calcium- and calmodulin-dependent protein kinase complex +namespace: cellular_component +def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] +synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] +synonym: "CAMK2" EXACT [] +synonym: "CaMKII" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005955 +name: calcineurin complex +namespace: cellular_component +def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [PMID:26794871] +synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] +synonym: "protein phosphatase type 2B complex" EXACT [] +is_a: GO:0005963 ! magnesium-dependent protein serine/threonine phosphatase complex + +[Term] +id: GO:0005956 +name: protein kinase CK2 complex +namespace: cellular_component +def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. +synonym: "casein kinase II complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005957 +name: obsolete debranching enzyme +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. +synonym: "debranching enzyme" EXACT [] +is_obsolete: true +consider: GO:0043033 + +[Term] +id: GO:0005958 +name: DNA-dependent protein kinase-DNA ligase 4 complex +namespace: cellular_component +alt_id: GO:0005959 +def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] +is_a: GO:0070419 ! nonhomologous end joining complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0005960 +name: glycine cleavage complex +namespace: cellular_component +alt_id: GO:0005961 +alt_id: GO:0070015 +def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] +subset: goslim_pir +synonym: "glycine cleavage system" EXACT [] +synonym: "glycine decarboxylase complex" EXACT [] +synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] +synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] +synonym: "glycine synthase complex" EXACT [] +xref: Wikipedia:Glycine_decarboxylase_complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005962 +name: mitochondrial isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) + +[Term] +id: GO:0005963 +name: magnesium-dependent protein serine/threonine phosphatase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [PMID:17517611, PMID:22343722] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0005964 +name: phosphorylase kinase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] +is_a: GO:1902554 ! serine/threonine protein kinase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005965 +name: protein farnesyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005966 +name: cyclic-nucleotide phosphodiesterase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] +synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0005967 +name: mitochondrial pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD [] +is_a: GO:0045254 ! pyruvate dehydrogenase complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0005968 +name: Rab-protein geranylgeranyltransferase complex +namespace: cellular_component +def: "An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein)." [GOC:jl, PMID:11886217] +synonym: "GGTase-II complex" EXACT [] +synonym: "Rab geranylgeranyltransferase complex" EXACT [] +synonym: "RabGGTase complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005969 +name: serine-pyruvate aminotransferase complex +namespace: cellular_component +alt_id: GO:0005970 +def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] +synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] +synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0005971 +name: ribonucleoside-diphosphate reductase complex +namespace: cellular_component +def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1] +synonym: "ribonucleotide reductase complex" EXACT [GOC:mah] +synonym: "RNR complex" EXACT [GOC:mah] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0005972 +name: obsolete fibrinogen alpha chain +namespace: cellular_component +alt_id: GO:0008005 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "fibrinogen alpha chain" EXACT [] +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005973 +name: obsolete fibrinogen beta chain +namespace: cellular_component +alt_id: GO:0008006 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "fibrinogen beta chain" EXACT [] +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005974 +name: obsolete fibrinogen gamma chain +namespace: cellular_component +alt_id: GO:0008007 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "fibrinogen gamma chain" EXACT [] +is_obsolete: true +consider: GO:0005577 + +[Term] +id: GO:0005975 +name: carbohydrate metabolic process +namespace: biological_process +alt_id: GO:0044261 +alt_id: GO:0044723 +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_pombe +subset: goslim_yeast +synonym: "carbohydrate metabolism" EXACT [] +synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] +synonym: "single-organism carbohydrate metabolic process" RELATED [] +xref: Wikipedia:Carbohydrate_metabolism +is_a: GO:0044238 ! primary metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0005976 +name: polysaccharide metabolic process +namespace: biological_process +alt_id: GO:0044263 +def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [ISBN:0198547684] +subset: goslim_pir +synonym: "glycan metabolic process" NARROW [] +synonym: "glycan metabolism" NARROW [] +synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] +synonym: "polysaccharide metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0005977 +name: glycogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] +synonym: "glycogen metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0006112 ! energy reserve metabolic process + +[Term] +id: GO:0005978 +name: glycogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +synonym: "glycogen anabolism" EXACT [] +synonym: "glycogen biosynthesis" EXACT [] +synonym: "glycogen formation" EXACT [] +synonym: "glycogen synthesis" EXACT [] +xref: MetaCyc:GLYCOGENSYNTH-PWY +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0005979 +name: regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "regulation of glycogen anabolism" EXACT [] +synonym: "regulation of glycogen biosynthesis" EXACT [] +synonym: "regulation of glycogen formation" EXACT [] +synonym: "regulation of glycogen synthesis" EXACT [] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +relationship: regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0005980 +name: glycogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] +synonym: "glycogen breakdown" EXACT [] +synonym: "glycogen catabolism" EXACT [] +synonym: "glycogen degradation" EXACT [] +synonym: "glycogenolysis" EXACT [GOC:sl] +xref: MetaCyc:GLYCOCAT-PWY +is_a: GO:0005977 ! glycogen metabolic process +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0005981 +name: regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +synonym: "regulation of glycogen breakdown" EXACT [] +synonym: "regulation of glycogen catabolism" EXACT [] +synonym: "regulation of glycogen degradation" EXACT [] +synonym: "regulation of glycogenolysis" EXACT [GOC:sl] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +relationship: regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0005982 +name: starch metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732] +synonym: "starch metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process + +[Term] +id: GO:0005983 +name: starch catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] +synonym: "starch breakdown" EXACT [] +synonym: "starch catabolism" EXACT [] +synonym: "starch degradation" EXACT [] +xref: MetaCyc:PWY-842 +is_a: GO:0005982 ! starch metabolic process +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0005984 +name: disaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:0192800981] +synonym: "disaccharide metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0005985 +name: sucrose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +synonym: "sucrose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005986 +name: sucrose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +synonym: "sucrose anabolism" EXACT [] +synonym: "sucrose biosynthesis" EXACT [] +synonym: "sucrose formation" EXACT [] +synonym: "sucrose synthesis" EXACT [] +xref: MetaCyc:SUCSYN-PWY +is_a: GO:0005985 ! sucrose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005987 +name: sucrose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] +synonym: "sucrose breakdown" EXACT [] +synonym: "sucrose catabolism" EXACT [] +synonym: "sucrose degradation" EXACT [] +is_a: GO:0005985 ! sucrose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005988 +name: lactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +synonym: "lactose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005989 +name: lactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +synonym: "lactose anabolism" EXACT [] +synonym: "lactose biosynthesis" EXACT [] +synonym: "lactose formation" EXACT [] +synonym: "lactose synthesis" EXACT [] +is_a: GO:0005988 ! lactose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005990 +name: lactose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] +synonym: "lactose breakdown" EXACT [] +synonym: "lactose catabolism" EXACT [] +synonym: "lactose degradation" EXACT [] +is_a: GO:0005988 ! lactose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005991 +name: trehalose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +synonym: "mycose metabolic process" EXACT [] +synonym: "mycose metabolism" EXACT [] +synonym: "mykose metabolic process" EXACT [] +synonym: "mykose metabolism" EXACT [] +synonym: "trehalose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005992 +name: trehalose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +synonym: "mycose biosynthesis" EXACT [] +synonym: "mycose biosynthetic process" EXACT [] +synonym: "mykose biosynthesis" EXACT [] +synonym: "mykose biosynthetic process" EXACT [] +synonym: "trehalose anabolism" EXACT [] +synonym: "trehalose biosynthesis" EXACT [] +synonym: "trehalose formation" EXACT [] +synonym: "trehalose synthesis" EXACT [] +xref: MetaCyc:PWY-881 +xref: MetaCyc:TREHALOSESYN-PWY +xref: MetaCyc:TRESYN-PWY +is_a: GO:0005991 ! trehalose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0005993 +name: trehalose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] +synonym: "mycose catabolic process" EXACT [] +synonym: "mycose catabolism" EXACT [] +synonym: "mykose catabolic process" EXACT [] +synonym: "mykose catabolism" EXACT [] +synonym: "trehalose breakdown" EXACT [] +synonym: "trehalose catabolism" EXACT [] +synonym: "trehalose degradation" EXACT [] +xref: MetaCyc:TREDEGLOW-PWY +is_a: GO:0005991 ! trehalose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005994 +name: melibiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] +synonym: "melibiose metabolism" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:0005995 +name: melibiose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] +synonym: "melibiose breakdown" EXACT [] +synonym: "melibiose catabolism" EXACT [] +synonym: "melibiose degradation" EXACT [] +is_a: GO:0005994 ! melibiose metabolic process +is_a: GO:0046352 ! disaccharide catabolic process + +[Term] +id: GO:0005996 +name: monosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] +synonym: "monosaccharide metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0005997 +name: xylulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +synonym: "xylulose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0005998 +name: xylulose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +synonym: "xylulose breakdown" EXACT [] +synonym: "xylulose catabolism" EXACT [] +synonym: "xylulose degradation" EXACT [] +xref: MetaCyc:XYLCAT-PWY +is_a: GO:0005997 ! xylulose metabolic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:0005999 +name: xylulose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] +synonym: "xylulose anabolism" EXACT [] +synonym: "xylulose biosynthesis" EXACT [] +synonym: "xylulose formation" EXACT [] +synonym: "xylulose synthesis" EXACT [] +is_a: GO:0005997 ! xylulose metabolic process +is_a: GO:0019322 ! pentose biosynthetic process + +[Term] +id: GO:0006000 +name: fructose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732] +synonym: "fructose metabolism" EXACT [] +xref: Wikipedia:Fructose +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006001 +name: fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] +synonym: "fructose breakdown" EXACT [] +synonym: "fructose catabolism" EXACT [] +synonym: "fructose degradation" EXACT [] +is_a: GO:0006000 ! fructose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0006002 +name: fructose 6-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732] +synonym: "fructose 6-phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0006003 +name: fructose 2,6-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732] +synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0006004 +name: fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] +synonym: "fucose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006005 +name: L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] +synonym: "L-fucose anabolism" EXACT [] +synonym: "L-fucose biosynthesis" EXACT [] +synonym: "L-fucose formation" EXACT [] +synonym: "L-fucose synthesis" EXACT [] +is_a: GO:0042353 ! fucose biosynthetic process +is_a: GO:0042354 ! L-fucose metabolic process + +[Term] +id: GO:0006006 +name: glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] +synonym: "cellular glucose metabolic process" EXACT [GOC:vw] +synonym: "glucose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006007 +name: glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] +synonym: "glucose breakdown" EXACT [] +synonym: "glucose catabolism" EXACT [] +synonym: "glucose degradation" EXACT [] +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0006009 +name: glucose 1-phosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0019255 ! glucose 1-phosphate metabolic process + +[Term] +id: GO:0006011 +name: UDP-glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-glucose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0006012 +name: galactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] +synonym: "galactose metabolism" EXACT [] +xref: Wikipedia:Galactose +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006013 +name: mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732] +synonym: "mannose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0006014 +name: D-ribose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732] +synonym: "D-ribose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0006015 +name: 5-phosphoribose 1-diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] +synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] +synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] +synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] +synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] +synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] +synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] +synonym: "PRPP biosynthetic process" EXACT [] +xref: MetaCyc:PWY0-661 +is_a: GO:0046390 ! ribose phosphate biosynthetic process +is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process + +[Term] +id: GO:0006016 +name: 2-deoxyribose 1-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732] +synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] +synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] +synonym: "2-deoxyribose 1-phosphate formation" EXACT [] +synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] +is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process +is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process + +[Term] +id: GO:0006017 +name: deoxyribose 1,5-bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] +synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] +synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] +is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process +is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process + +[Term] +id: GO:0006018 +name: 2-deoxyribose 1-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] +synonym: "2-deoxyribose 1-phosphate breakdown" EXACT [] +synonym: "2-deoxyribose 1-phosphate catabolism" EXACT [] +synonym: "2-deoxyribose 1-phosphate degradation" EXACT [] +synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah] +is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process +is_a: GO:0046386 ! deoxyribose phosphate catabolic process + +[Term] +id: GO:0006019 +name: deoxyribose 5-phosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process + +[Term] +id: GO:0006020 +name: inositol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684] +synonym: "inositol metabolism" EXACT [] +synonym: "myo-inositol metabolic process" NARROW [] +synonym: "myo-inositol metabolism" NARROW [] +synonym: "vitamin Bh metabolic process" EXACT [] +synonym: "vitamin Bh metabolism" EXACT [] +xref: Wikipedia:Inositol +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0006021 +name: inositol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ISBN:0198547684] +synonym: "inositol anabolism" EXACT [] +synonym: "inositol biosynthesis" EXACT [] +synonym: "inositol formation" EXACT [] +synonym: "inositol synthesis" EXACT [] +synonym: "myo-inositol biosynthesis" NARROW [] +synonym: "myo-inositol biosynthetic process" NARROW [] +synonym: "vitamin Bh biosynthesis" EXACT [] +synonym: "vitamin Bh biosynthetic process" EXACT [] +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process + +[Term] +id: GO:0006022 +name: aminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] +synonym: "aminoglycan metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006023 +name: aminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] +synonym: "aminoglycan anabolism" EXACT [] +synonym: "aminoglycan biosynthesis" EXACT [] +synonym: "aminoglycan formation" EXACT [] +synonym: "aminoglycan synthesis" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0006024 +name: glycosaminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +synonym: "glycosaminoglycan anabolism" EXACT [] +synonym: "glycosaminoglycan biosynthesis" EXACT [] +synonym: "glycosaminoglycan formation" EXACT [] +synonym: "glycosaminoglycan synthesis" EXACT [] +is_a: GO:0006023 ! aminoglycan biosynthetic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0006025 +name: galactosaminoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +synonym: "galactosaminoglycan anabolism" EXACT [] +synonym: "galactosaminoglycan biosynthesis" EXACT [] +synonym: "galactosaminoglycan formation" EXACT [] +synonym: "galactosaminoglycan synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0046350 ! galactosaminoglycan metabolic process + +[Term] +id: GO:0006026 +name: aminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] +synonym: "aminoglycan breakdown" EXACT [] +synonym: "aminoglycan catabolism" EXACT [] +synonym: "aminoglycan degradation" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0006027 +name: glycosaminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +synonym: "glycosaminoglycan breakdown" EXACT [] +synonym: "glycosaminoglycan catabolism" EXACT [] +synonym: "glycosaminoglycan degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0006028 +name: galactosaminoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +synonym: "galactosaminoglycan breakdown" EXACT [] +synonym: "galactosaminoglycan catabolism" EXACT [] +synonym: "galactosaminoglycan degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0046350 ! galactosaminoglycan metabolic process + +[Term] +id: GO:0006029 +name: proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] +synonym: "proteoglycan metabolism" EXACT [] +synonym: "proteoglycan sulfate transfer" NARROW [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0006030 +name: chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] +synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] +synonym: "chitin metabolism" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:1901071 ! glucosamine-containing compound metabolic process + +[Term] +id: GO:0006031 +name: chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] +synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] +synonym: "chitin anabolism" EXACT [] +synonym: "chitin biosynthesis" EXACT [] +synonym: "chitin formation" EXACT [] +synonym: "chitin synthesis" EXACT [] +is_a: GO:0006023 ! aminoglycan biosynthetic process +is_a: GO:0006030 ! chitin metabolic process +is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process + +[Term] +id: GO:0006032 +name: chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] +synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] +synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] +synonym: "chitin breakdown" EXACT [] +synonym: "chitin catabolism" EXACT [] +synonym: "chitin degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0006030 ! chitin metabolic process +is_a: GO:1901072 ! glucosamine-containing compound catabolic process + +[Term] +id: GO:0006033 +name: chitin localization +namespace: biological_process +def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] +synonym: "chitin localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of chitin localization" EXACT [] +is_a: GO:0033037 ! polysaccharide localization + +[Term] +id: GO:0006034 +name: cuticle chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin metabolism" EXACT [] +is_a: GO:0006030 ! chitin metabolic process + +[Term] +id: GO:0006035 +name: cuticle chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin anabolism" EXACT [] +synonym: "cuticle chitin biosynthesis" EXACT [] +synonym: "cuticle chitin formation" EXACT [] +synonym: "cuticle chitin synthesis" EXACT [] +is_a: GO:0006031 ! chitin biosynthetic process +is_a: GO:0006034 ! cuticle chitin metabolic process +relationship: part_of GO:0040003 ! chitin-based cuticle development + +[Term] +id: GO:0006036 +name: cuticle chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] +synonym: "cuticle chitin breakdown" EXACT [] +synonym: "cuticle chitin catabolism" EXACT [] +synonym: "cuticle chitin degradation" EXACT [] +is_a: GO:0006032 ! chitin catabolic process +is_a: GO:0006034 ! cuticle chitin metabolic process + +[Term] +id: GO:0006037 +name: cell wall chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +synonym: "cell wall chitin metabolism" EXACT [] +is_a: GO:0006030 ! chitin metabolic process +relationship: part_of GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0006038 +name: cell wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +synonym: "cell wall chitin anabolism" EXACT [] +synonym: "cell wall chitin biosynthesis" EXACT [] +synonym: "cell wall chitin formation" EXACT [] +synonym: "cell wall chitin synthesis" EXACT [] +is_a: GO:0006031 ! chitin biosynthetic process +is_a: GO:0006037 ! cell wall chitin metabolic process +relationship: part_of GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0006039 +name: cell wall chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] +synonym: "cell wall chitin breakdown" EXACT [] +synonym: "cell wall chitin catabolism" EXACT [] +synonym: "cell wall chitin degradation" EXACT [] +is_a: GO:0006032 ! chitin catabolic process +is_a: GO:0006037 ! cell wall chitin metabolic process + +[Term] +id: GO:0006040 +name: amino sugar metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +synonym: "amino sugar metabolism" EXACT [] +synonym: "aminosaccharide metabolic process" EXACT [] +synonym: "aminosaccharide metabolism" EXACT [] +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0006041 +name: glucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] +synonym: "chitosamine metabolic process" EXACT [] +synonym: "chitosamine metabolism" EXACT [] +synonym: "glucosamine metabolism" EXACT [] +is_a: GO:1901071 ! glucosamine-containing compound metabolic process + +[Term] +id: GO:0006042 +name: glucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] +synonym: "chitosamine biosynthesis" EXACT [] +synonym: "chitosamine biosynthetic process" EXACT [] +synonym: "glucosamine anabolism" EXACT [] +synonym: "glucosamine biosynthesis" EXACT [] +synonym: "glucosamine formation" EXACT [] +synonym: "glucosamine synthesis" EXACT [] +is_a: GO:0006041 ! glucosamine metabolic process +is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process + +[Term] +id: GO:0006043 +name: glucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] +synonym: "chitosamine catabolic process" EXACT [] +synonym: "chitosamine catabolism" EXACT [] +synonym: "glucosamine breakdown" EXACT [] +synonym: "glucosamine catabolism" EXACT [] +synonym: "glucosamine degradation" EXACT [] +xref: MetaCyc:GLUAMCAT-PWY +is_a: GO:0006041 ! glucosamine metabolic process +is_a: GO:1901072 ! glucosamine-containing compound catabolic process + +[Term] +id: GO:0006044 +name: N-acetylglucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] +synonym: "N-acetylglucosamine metabolism" EXACT [] +is_a: GO:1901071 ! glucosamine-containing compound metabolic process + +[Term] +id: GO:0006045 +name: N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] +synonym: "N-acetylglucosamine anabolism" EXACT [] +synonym: "N-acetylglucosamine biosynthesis" EXACT [] +synonym: "N-acetylglucosamine formation" EXACT [] +synonym: "N-acetylglucosamine synthesis" EXACT [] +is_a: GO:0006044 ! N-acetylglucosamine metabolic process +is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process + +[Term] +id: GO:0006046 +name: N-acetylglucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] +synonym: "N-acetylglucosamine breakdown" EXACT [] +synonym: "N-acetylglucosamine catabolism" EXACT [] +synonym: "N-acetylglucosamine degradation" EXACT [] +is_a: GO:0006044 ! N-acetylglucosamine metabolic process +is_a: GO:1901072 ! glucosamine-containing compound catabolic process + +[Term] +id: GO:0006047 +name: UDP-N-acetylglucosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0006048 +name: UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-GlcNAc biosynthesis" EXACT [] +synonym: "UDP-GlcNAc biosynthetic process" EXACT [] +synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] +synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] +synonym: "UDP-N-acetylglucosamine formation" EXACT [] +synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] +xref: MetaCyc:UDPNAGSYN-PWY +is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0006049 +name: UDP-N-acetylglucosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] +synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] +synonym: "UDP-N-acetylglucosamine degradation" EXACT [] +is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process +is_a: GO:0009227 ! nucleotide-sugar catabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0006050 +name: mannosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators] +synonym: "mannosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:0006051 +name: N-acetylmannosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] +synonym: "N-acetylmannosamine metabolism" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process + +[Term] +id: GO:0006052 +name: N-acetylmannosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] +synonym: "N-acetylmannosamine anabolism" EXACT [] +synonym: "N-acetylmannosamine biosynthesis" EXACT [] +synonym: "N-acetylmannosamine formation" EXACT [] +synonym: "N-acetylmannosamine synthesis" EXACT [] +is_a: GO:0006051 ! N-acetylmannosamine metabolic process +is_a: GO:0046347 ! mannosamine biosynthetic process + +[Term] +id: GO:0006053 +name: N-acetylmannosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] +synonym: "N-acetylmannosamine breakdown" EXACT [] +synonym: "N-acetylmannosamine catabolism" EXACT [] +synonym: "N-acetylmannosamine degradation" EXACT [] +is_a: GO:0006051 ! N-acetylmannosamine metabolic process +is_a: GO:0046346 ! mannosamine catabolic process + +[Term] +id: GO:0006054 +name: N-acetylneuraminate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] +synonym: "N-acetylneuraminate metabolism" EXACT [] +synonym: "sialic acid metabolic process" BROAD [] +synonym: "sialic acid metabolism" BROAD [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006055 +name: CMP-N-acetylneuraminate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] +synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] +synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] +synonym: "CMP-N-acetylneuraminate formation" EXACT [] +synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process + +[Term] +id: GO:0006056 +name: mannoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732] +synonym: "mannoprotein metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0006057 +name: mannoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732] +synonym: "mannoprotein anabolism" EXACT [] +synonym: "mannoprotein biosynthesis" EXACT [] +synonym: "mannoprotein formation" EXACT [] +synonym: "mannoprotein synthesis" EXACT [] +is_a: GO:0006056 ! mannoprotein metabolic process +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0006058 +name: mannoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues." [ISBN:0198506732] +synonym: "mannoprotein breakdown" EXACT [] +synonym: "mannoprotein catabolism" EXACT [] +synonym: "mannoprotein degradation" EXACT [] +is_a: GO:0006056 ! mannoprotein metabolic process +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0006059 +name: hexitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexitol metabolism" EXACT [] +synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] +synonym: "sugar alcohol (hexitol) metabolism" EXACT [] +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0006060 +name: sorbitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "sorbitol metabolism" EXACT [] +xref: MetaCyc:P461-PWY +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0006061 +name: sorbitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "sorbitol anabolism" EXACT [] +synonym: "sorbitol biosynthesis" EXACT [] +synonym: "sorbitol formation" EXACT [] +synonym: "sorbitol synthesis" EXACT [] +is_a: GO:0006060 ! sorbitol metabolic process +is_a: GO:0019406 ! hexitol biosynthetic process + +[Term] +id: GO:0006062 +name: sorbitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "sorbitol breakdown" EXACT [] +synonym: "sorbitol catabolism" EXACT [] +synonym: "sorbitol degradation" EXACT [] +xref: MetaCyc:SORBDEG-PWY +is_a: GO:0006060 ! sorbitol metabolic process +is_a: GO:0019407 ! hexitol catabolic process + +[Term] +id: GO:0006063 +name: uronic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732] +synonym: "uronic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006064 +name: glucuronate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] +synonym: "glucuronate breakdown" EXACT [] +synonym: "glucuronate catabolism" EXACT [] +synonym: "glucuronate degradation" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0006065 +name: UDP-glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-glucuronate anabolism" EXACT [] +synonym: "UDP-glucuronate biosynthesis" EXACT [] +synonym: "UDP-glucuronate formation" EXACT [] +synonym: "UDP-glucuronate synthesis" EXACT [] +xref: MetaCyc:PWY-4841 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046398 ! UDP-glucuronate metabolic process + +[Term] +id: GO:0006066 +name: alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_pir +synonym: "alcohol metabolism" EXACT [] +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0006067 +name: ethanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] +synonym: "ethanol metabolism" EXACT [] +is_a: GO:0034308 ! primary alcohol metabolic process + +[Term] +id: GO:0006068 +name: ethanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] +synonym: "ethanol breakdown" EXACT [] +synonym: "ethanol catabolism" EXACT [] +synonym: "ethanol degradation" EXACT [] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process + +[Term] +id: GO:0006069 +name: ethanol oxidation +namespace: biological_process +def: "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0006070 +name: octanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] +synonym: "octanol metabolism" EXACT [] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:0006071 +name: glycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] +synonym: "glycerol metabolism" EXACT [] +xref: MetaCyc:GLYCEROLMETAB-PWY +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0006072 +name: glycerol-3-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] +synonym: "glycerol-3-phosphate metabolism" EXACT [] +is_a: GO:0052646 ! alditol phosphate metabolic process + +[Term] +id: GO:0006073 +name: cellular glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell." [ISBN:0198547684] +synonym: "cellular glucan metabolism" EXACT [] +is_a: GO:0044042 ! glucan metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0006074 +name: (1->3)-beta-D-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [ISBN:0198506732] +synonym: "1,3-beta-D-glucan metabolic process" BROAD [GOC:tb] +synonym: "1,3-beta-D-glucan metabolism" EXACT [] +synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb] +synonym: "beta-1,3 glucan metabolic process" EXACT [] +synonym: "beta-1,3 glucan metabolism" EXACT [] +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0006075 +name: (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [GOC:ai] +synonym: "1,3-beta-D-glucan biosynthetic process" EXACT [] +synonym: "1,3-beta-glucan anabolism" EXACT [] +synonym: "1,3-beta-glucan biosynthesis" EXACT [] +synonym: "1,3-beta-glucan formation" EXACT [] +synonym: "1,3-beta-glucan synthesis" EXACT [] +synonym: "beta-1,3 glucan anabolism" EXACT [] +synonym: "beta-1,3 glucan biosynthesis" EXACT [] +synonym: "beta-1,3 glucan biosynthetic process" EXACT [] +synonym: "beta-1,3 glucan formation" EXACT [] +synonym: "beta-1,3 glucan synthesis" EXACT [] +is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0006076 +name: (1->3)-beta-D-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans." [GOC:ai] +synonym: "1,3-beta-D-glucan catabolic process" EXACT [] +synonym: "1,3-beta-glucan breakdown" EXACT [] +synonym: "1,3-beta-glucan catabolism" EXACT [] +synonym: "1,3-beta-glucan degradation" EXACT [] +synonym: "beta-1,3 glucan breakdown" EXACT [] +synonym: "beta-1,3 glucan catabolic process" EXACT [] +synonym: "beta-1,3 glucan catabolism" EXACT [] +synonym: "beta-1,3 glucan degradation" EXACT [] +is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process +is_a: GO:0051275 ! beta-glucan catabolic process + +[Term] +id: GO:0006077 +name: (1->6)-beta-D-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds." [ISBN:0198506732] +synonym: "1,6-beta-glucan metabolic process" EXACT [] +synonym: "1,6-beta-glucan metabolism" EXACT [] +synonym: "beta-1,6 glucan metabolic process" EXACT [] +synonym: "beta-1,6 glucan metabolism" EXACT [] +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0006078 +name: (1->6)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:ai] +synonym: "1,6-beta-glucan anabolism" EXACT [] +synonym: "1,6-beta-glucan biosynthesis" EXACT [] +synonym: "1,6-beta-glucan biosynthetic process" EXACT [] +synonym: "1,6-beta-glucan formation" EXACT [] +synonym: "1,6-beta-glucan synthesis" EXACT [] +synonym: "beta-1,6 glucan anabolism" EXACT [] +synonym: "beta-1,6 glucan biosynthesis" EXACT [] +synonym: "beta-1,6 glucan biosynthetic process" EXACT [] +synonym: "beta-1,6 glucan formation" EXACT [] +synonym: "beta-1,6 glucan synthesis" EXACT [] +is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0006079 +name: (1->6)-beta-D-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans." [GOC:ai] +synonym: "1,6-beta-D-glucan breakdown" EXACT [] +synonym: "1,6-beta-D-glucan catabolic process" EXACT [] +synonym: "1,6-beta-D-glucan catabolism" EXACT [] +synonym: "1,6-beta-D-glucan degradation" EXACT [] +synonym: "beta-1,6 glucan breakdown" EXACT [] +synonym: "beta-1,6 glucan catabolic process" EXACT [] +synonym: "beta-1,6 glucan catabolism" EXACT [] +synonym: "beta-1,6 glucan degradation" EXACT [] +is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process +is_a: GO:0051275 ! beta-glucan catabolic process + +[Term] +id: GO:0006080 +name: substituted mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] +synonym: "substituted mannan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0006081 +name: cellular aldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] +subset: goslim_pir +synonym: "aldehyde metabolism" EXACT [] +synonym: "alkanal metabolic process" EXACT [] +synonym: "alkanal metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0006082 +name: organic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +subset: goslim_pir +synonym: "organic acid metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0006083 +name: acetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "acetate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006084 +name: acetyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] +synonym: "acetyl coenzyme A metabolic process" EXACT [] +synonym: "acetyl coenzyme A metabolism" EXACT [] +synonym: "acetyl-CoA metabolism" EXACT [] +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:0006085 +name: acetyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] +synonym: "acetyl-CoA anabolism" EXACT [] +synonym: "acetyl-CoA biosynthesis" EXACT [] +synonym: "acetyl-CoA formation" EXACT [] +synonym: "acetyl-CoA synthesis" EXACT [] +xref: MetaCyc:PWY-5173 +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process + +[Term] +id: GO:0006086 +name: acetyl-CoA biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] +synonym: "acetyl-CoA formation from pyruvate" EXACT [] +synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] +synonym: "pyruvate dehydrogenase pathway" EXACT [] +xref: MetaCyc:PYRUVDEHYD-PWY +is_a: GO:0006085 ! acetyl-CoA biosynthetic process +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0006088 +name: obsolete acetate to acetyl-CoA +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "acetate to acetyl-CoA" EXACT [] +is_obsolete: true +consider: GO:0003987 + +[Term] +id: GO:0006089 +name: lactate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] +synonym: "2-hydroxypropanoate metabolic process" EXACT [] +synonym: "2-hydroxypropanoate metabolism" EXACT [] +synonym: "alpha-hydroxypropionate metabolic process" EXACT [] +synonym: "alpha-hydroxypropionate metabolism" EXACT [] +synonym: "lactate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0006090 +name: pyruvate metabolic process +namespace: biological_process +alt_id: GO:0006087 +def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] +subset: goslim_drosophila +synonym: "pyruvate dehydrogenase bypass" RELATED [] +synonym: "pyruvate metabolism" EXACT [] +xref: MetaCyc:P41-PWY +xref: Wikipedia:Pyruvic_acid +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006091 +name: generation of precursor metabolites and energy +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_pombe +subset: goslim_yeast +synonym: "energy pathways" BROAD [] +synonym: "intermediary metabolism" RELATED [GOC:mah] +synonym: "metabolic energy generation" RELATED [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006094 +name: gluconeogenesis +namespace: biological_process +def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] +synonym: "glucose biosynthesis" EXACT [] +synonym: "glucose biosynthetic process" EXACT [] +xref: MetaCyc:GLUCONEO-PWY +xref: Wikipedia:Gluconeogenesis +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0006096 +name: glycolytic process +namespace: biological_process +alt_id: GO:0019641 +alt_id: GO:0019642 +def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] +synonym: "anaerobic glycolysis" RELATED [] +synonym: "Embden-Meyerhof pathway" RELATED [] +synonym: "Embden-Meyerhof-Parnas pathway" RELATED [] +synonym: "glycolysis" RELATED [GOC:dph] +synonym: "modifed Embden-Meyerhof pathway" RELATED [] +xref: MetaCyc:GLYCOLYSIS-VARIANTS +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0006757 ! ATP generation from ADP +is_a: GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0006097 +name: glyoxylate cycle +namespace: biological_process +def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] +synonym: "glyoxylate bypass" EXACT [] +xref: MetaCyc:GLYOXYLATE-BYPASS +xref: Wikipedia:Glyoxylate_cycle +is_a: GO:0044262 ! cellular carbohydrate metabolic process +is_a: GO:0046487 ! glyoxylate metabolic process + +[Term] +id: GO:0006098 +name: pentose-phosphate shunt +namespace: biological_process +def: "The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate)." [GOC:pde, ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] +synonym: "hexose monophosphate pathway" EXACT [] +synonym: "pentose phosphate pathway" EXACT [] +synonym: "pentose phosphate shunt" EXACT [] +synonym: "pentose-phosphate pathway" EXACT [] +xref: KEGG_PATHWAY:00030 +xref: MetaCyc:PENTOSE-P-PWY +xref: Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens" +xref: Wikipedia:Pentose_phosphate_pathway +is_a: GO:0006740 ! NADPH regeneration +is_a: GO:0051156 ! glucose 6-phosphate metabolic process + +[Term] +id: GO:0006099 +name: tricarboxylic acid cycle +namespace: biological_process +def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] +synonym: "citric acid cycle" EXACT [] +synonym: "Krebs cycle" EXACT [] +synonym: "TCA cycle" EXACT [] +xref: MetaCyc:P105-PWY +xref: MetaCyc:P42-PWY +xref: MetaCyc:TCA +xref: Wikipedia:Tricarboxylic_acid_cycle +is_a: GO:0044238 ! primary metabolic process +relationship: part_of GO:0009060 ! aerobic respiration + +[Term] +id: GO:0006100 +name: obsolete tricarboxylic acid cycle intermediate metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] +comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. +synonym: "citric acid cycle intermediate metabolic process" EXACT [] +synonym: "citric acid cycle intermediate metabolism" EXACT [] +synonym: "Krebs cycle intermediate metabolic process" EXACT [] +synonym: "Krebs cycle intermediate metabolism" EXACT [] +synonym: "TCA intermediate metabolic process" EXACT [] +synonym: "TCA intermediate metabolism" EXACT [] +synonym: "tricarboxylic acid cycle intermediate metabolic process" EXACT [] +synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] +is_obsolete: true +consider: GO:0006099 +consider: GO:0006101 +consider: GO:0006103 +consider: GO:0006104 +consider: GO:0006105 +consider: GO:0006106 +consider: GO:0006107 +consider: GO:0006108 + +[Term] +id: GO:0006101 +name: citrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] +synonym: "citrate metabolism" EXACT [] +is_a: GO:0072350 ! tricarboxylic acid metabolic process + +[Term] +id: GO:0006102 +name: isocitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732] +synonym: "isocitrate metabolism" EXACT [] +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0006103 +name: 2-oxoglutarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732] +synonym: "2-ketoglutarate metabolic process" EXACT [] +synonym: "2-ketoglutarate metabolism" EXACT [] +synonym: "2-oxoglutarate metabolism" EXACT [] +synonym: "alpha-ketoglutarate metabolic process" EXACT [] +synonym: "alpha-ketoglutarate metabolism" EXACT [] +synonym: "alpha-oxoglutarate metabolic process" EXACT [] +synonym: "alpha-oxoglutarate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006104 +name: succinyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] +synonym: "succinyl-CoA metabolism" EXACT [] +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:0006105 +name: succinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732] +synonym: "succinate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006106 +name: fumarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732] +synonym: "fumarate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006107 +name: oxaloacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732] +synonym: "oxaloacetate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006108 +name: malate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] +synonym: "malate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006109 +name: regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] +synonym: "regulation of carbohydrate metabolism" EXACT [] +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0006110 +name: regulation of glycolytic process +namespace: biological_process +alt_id: GO:0090525 +def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] +synonym: "regulation of glycolysis involved in cellular glucose homeostasis" EXACT [] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: regulates GO:0006096 ! glycolytic process + +[Term] +id: GO:0006111 +name: regulation of gluconeogenesis +namespace: biological_process +alt_id: GO:0090526 +def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] +synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED [] +synonym: "regulation of glucose biosynthesis" BROAD [] +synonym: "regulation of glucose biosynthetic process" BROAD [] +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0006112 +name: energy reserve metabolic process +namespace: biological_process +def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] +subset: goslim_pir +synonym: "energy reserve metabolism" EXACT [] +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0006113 +name: fermentation +namespace: biological_process +def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, MetaCyc:Fermentation] +subset: goslim_pir +xref: MetaCyc:FERMENTATION-PWY +xref: Wikipedia:Fermentation_(biochemistry) +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0006114 +name: glycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] +synonym: "glycerol anabolism" EXACT [] +synonym: "glycerol biosynthesis" EXACT [] +synonym: "glycerol formation" EXACT [] +synonym: "glycerol synthesis" EXACT [] +is_a: GO:0006071 ! glycerol metabolic process +is_a: GO:0019401 ! alditol biosynthetic process + +[Term] +id: GO:0006115 +name: ethanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] +synonym: "ethanol anabolism" EXACT [] +synonym: "ethanol biosynthesis" EXACT [] +synonym: "ethanol formation" EXACT [] +synonym: "ethanol synthesis" EXACT [] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process + +[Term] +id: GO:0006116 +name: NADH oxidation +namespace: biological_process +def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] +synonym: "NAD (reduced) dehydrogenation" EXACT [] +synonym: "NAD (reduced) oxidation" EXACT [] +synonym: "NADH dehydrogenation" EXACT [] +synonym: "reduced NAD dehydrogenation" EXACT [] +synonym: "reduced NAD oxidation" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0006117 +name: acetaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators] +synonym: "acetaldehyde metabolism" EXACT [] +synonym: "ethanal metabolic process" EXACT [] +synonym: "ethanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0006118 +name: obsolete electron transport +namespace: biological_process +def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators] +comment: This term was made obsolete because it describes a molecular function. +synonym: "6-phosphofructokinase reduction" RELATED [] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "dihydrolipoamide reduction" RELATED [] +synonym: "dihydrolipoylprotein reduction" RELATED [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "electron transfer" EXACT [] +synonym: "electron transport" EXACT [] +synonym: "other pathways of electron transport" RELATED [] +synonym: "oxidized glutathione reduction" RELATED [] +synonym: "protein-disulfide reduction" RELATED [] +is_obsolete: true +consider: GO:0016491 +consider: GO:0022904 + +[Term] +id: GO:0006119 +name: oxidative phosphorylation +namespace: biological_process +def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] +subset: goslim_pir +synonym: "respiratory-chain phosphorylation" EXACT [] +xref: Wikipedia:Oxidative_phosphorylation +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0006120 +name: mitochondrial electron transport, NADH to ubiquinone +namespace: biological_process +def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation." [ISBN:0716731363] +synonym: "complex I (NADH to ubiquinone)" RELATED [] +synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] +is_a: GO:0019646 ! aerobic electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006121 +name: mitochondrial electron transport, succinate to ubiquinone +namespace: biological_process +def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] +synonym: "complex II (succinate to ubiquinone)" RELATED [] +synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] +synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] +is_a: GO:0019646 ! aerobic electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006122 +name: mitochondrial electron transport, ubiquinol to cytochrome c +namespace: biological_process +def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] +synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] +is_a: GO:0019646 ! aerobic electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006123 +name: mitochondrial electron transport, cytochrome c to oxygen +namespace: biological_process +def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] +synonym: "complex IV (reduction of O2)" RELATED [] +is_a: GO:0019646 ! aerobic electron transport chain +relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:0006124 +name: ferredoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732] +synonym: "ferredoxin metabolism" EXACT [] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006125 +name: obsolete thioredoxin pathway +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport] +comment: This term was made obsolete because it is not clear what it is intended to represent. +synonym: "thioredoxin pathway" EXACT [] +synonym: "thioredoxin reduction" NARROW [] +xref: MetaCyc:THIOREDOX-PWY +is_obsolete: true +consider: GO:0045454 + +[Term] +id: GO:0006126 +name: obsolete other pathways of electron transport +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other pathways of electron transport" EXACT [] +is_obsolete: true +replaced_by: GO:0022900 + +[Term] +id: GO:0006127 +name: glycerophosphate shuttle +namespace: biological_process +def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716720094, PMID:16368075] +xref: MetaCyc:PWY-6118 +is_a: GO:0006116 ! NADH oxidation +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process +relationship: part_of GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0006128 +name: obsolete oxidized glutathione reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. +synonym: "oxidized glutathione reduction" EXACT [] +is_obsolete: true +consider: GO:0004362 +consider: GO:0006749 +consider: GO:0022900 + +[Term] +id: GO:0006129 +name: obsolete protein-disulfide reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "protein-disulfide reduction" EXACT [] +synonym: "protein-disulphide reduction" EXACT [] +is_obsolete: true +consider: GO:0019153 +consider: GO:0022900 + +[Term] +id: GO:0006130 +name: obsolete 6-phosphofructokinase reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. +synonym: "6-phosphofructokinase reduction" EXACT [] +is_obsolete: true +consider: GO:0003872 +consider: GO:0022900 + +[Term] +id: GO:0006131 +name: obsolete dihydrolipoamide reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "dihydrolipoamide reduction" EXACT [] +is_obsolete: true +consider: GO:0004148 +consider: GO:0022900 +consider: GO:0051068 + +[Term] +id: GO:0006132 +name: obsolete dihydrolipoylprotein reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "dihydrolipoylprotein reduction" EXACT [] +is_obsolete: true +consider: GO:0004148 +consider: GO:0022900 + +[Term] +id: GO:0006133 +name: obsolete 5,10-methylenetetrahydrofolate oxidation +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_electron_transport] +comment: This term was made obsolete because it is defined as a function term and is in the process ontology. +synonym: "5,10-methylenetetrahydrofolate oxidation" EXACT [] +is_obsolete: true +consider: GO:0004487 +consider: GO:0004488 +consider: GO:0004489 +consider: GO:0033738 + +[Term] +id: GO:0006134 +name: obsolete dihydrobiopterin reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "dihydrobiopterin reduction" EXACT [] +is_obsolete: true +consider: GO:0022900 +consider: GO:0047040 +consider: GO:0051066 + +[Term] +id: GO:0006135 +name: obsolete dihydropteridine reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "dihydropteridine reduction" EXACT [] +is_obsolete: true +consider: GO:0004155 +consider: GO:0022900 +consider: GO:0051067 + +[Term] +id: GO:0006139 +name: nucleobase-containing compound metabolic process +namespace: biological_process +alt_id: GO:0055134 +def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] +subset: goslim_pir +subset: goslim_plant +synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044238 ! primary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0006140 +name: regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +synonym: "regulation of nucleotide metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0006141 +name: regulation of purine nucleobase metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] +synonym: "regulation of purine base metabolic process" EXACT [GOC:go_curators] +synonym: "regulation of purine base metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0006142 +name: regulation of pyrimidine nucleobase metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] +synonym: "regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] +synonym: "regulation of pyrimidine base metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0006143 +name: obsolete purine metabolic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "purine metabolic process" EXACT [] +is_obsolete: true +consider: GO:0006144 +consider: GO:0006163 +consider: GO:0042278 + +[Term] +id: GO:0006144 +name: purine nucleobase metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] +synonym: "purine base metabolic process" EXACT [GOC:go_curators] +synonym: "purine base metabolism" EXACT [] +synonym: "purine metabolic process" NARROW [] +synonym: "purine metabolism" NARROW [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0006145 +name: purine nucleobase catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] +synonym: "purine base breakdown" EXACT [] +synonym: "purine base catabolic process" EXACT [GOC:go_curators] +synonym: "purine base catabolism" EXACT [] +synonym: "purine base degradation" EXACT [] +is_a: GO:0006144 ! purine nucleobase metabolic process +is_a: GO:0046113 ! nucleobase catabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process + +[Term] +id: GO:0006146 +name: adenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732] +synonym: "adenine breakdown" EXACT [] +synonym: "adenine catabolism" EXACT [] +synonym: "adenine degradation" EXACT [] +is_a: GO:0006145 ! purine nucleobase catabolic process +is_a: GO:0046083 ! adenine metabolic process + +[Term] +id: GO:0006147 +name: guanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +synonym: "guanine breakdown" EXACT [] +synonym: "guanine catabolism" EXACT [] +synonym: "guanine degradation" EXACT [] +is_a: GO:0006145 ! purine nucleobase catabolic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0006148 +name: inosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +synonym: "inosine breakdown" EXACT [] +synonym: "inosine catabolism" EXACT [] +synonym: "inosine degradation" EXACT [] +is_a: GO:0046102 ! inosine metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0006149 +name: deoxyinosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +synonym: "deoxyinosine breakdown" EXACT [] +synonym: "deoxyinosine catabolism" EXACT [] +synonym: "deoxyinosine degradation" EXACT [] +is_a: GO:0046094 ! deoxyinosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006152 +name: purine nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] +synonym: "purine nucleoside breakdown" EXACT [] +synonym: "purine nucleoside catabolism" EXACT [] +synonym: "purine nucleoside degradation" EXACT [] +is_a: GO:0009164 ! nucleoside catabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process + +[Term] +id: GO:0006153 +name: obsolete purine nucleosidase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "purine nucleosidase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0008477 + +[Term] +id: GO:0006154 +name: adenosine catabolic process +namespace: biological_process +alt_id: GO:0006156 +def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +synonym: "adenosine breakdown" EXACT [] +synonym: "adenosine catabolism" EXACT [] +synonym: "adenosine degradation" EXACT [] +synonym: "adenosine phosphorolysis" RELATED [] +is_a: GO:0046085 ! adenosine metabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process + +[Term] +id: GO:0006155 +name: obsolete adenosine deaminase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "adenosine deaminase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0004000 + +[Term] +id: GO:0006157 +name: deoxyadenosine catabolic process +namespace: biological_process +alt_id: GO:0006159 +def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyadenosine breakdown" EXACT [] +synonym: "deoxyadenosine catabolism" EXACT [] +synonym: "deoxyadenosine degradation" EXACT [] +synonym: "deoxyadenosine phosphorolysis" RELATED [] +is_a: GO:0046090 ! deoxyadenosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006158 +name: obsolete deoxyadenosine deaminase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "deoxyadenosine deaminase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0046936 + +[Term] +id: GO:0006161 +name: deoxyguanosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] +synonym: "deoxyguanosine breakdown" EXACT [] +synonym: "deoxyguanosine catabolism" EXACT [] +synonym: "deoxyguanosine degradation" EXACT [] +is_a: GO:0042453 ! deoxyguanosine metabolic process +is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006162 +name: obsolete purine/pyrimidine nucleoside diphosphate reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "purine/pyrimidine nucleoside diphosphate reduction" EXACT [] +is_obsolete: true +consider: GO:0004748 + +[Term] +id: GO:0006163 +name: purine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine metabolic process" NARROW [] +synonym: "purine metabolism" NARROW [] +synonym: "purine nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0006164 +name: purine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleotide anabolism" EXACT [] +synonym: "purine nucleotide biosynthesis" EXACT [] +synonym: "purine nucleotide formation" EXACT [] +synonym: "purine nucleotide synthesis" EXACT [] +xref: MetaCyc:DENOVOPURINE2-PWY +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0006165 +name: nucleoside diphosphate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:0046939 ! nucleotide phosphorylation + +[Term] +id: GO:0006166 +name: purine ribonucleoside salvage +namespace: biological_process +def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +xref: MetaCyc:P121-PWY +is_a: GO:0043101 ! purine-containing compound salvage +is_a: GO:0043174 ! nucleoside salvage +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0006167 +name: AMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732] +synonym: "AMP anabolism" EXACT [] +synonym: "AMP biosynthesis" EXACT [] +synonym: "AMP formation" EXACT [] +synonym: "AMP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046033 ! AMP metabolic process + +[Term] +id: GO:0006168 +name: adenine salvage +namespace: biological_process +def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "adenine salvage pathway" EXACT [] +synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] +is_a: GO:0043096 ! purine nucleobase salvage +is_a: GO:0046084 ! adenine biosynthetic process + +[Term] +id: GO:0006169 +name: adenosine salvage +namespace: biological_process +def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0046086 ! adenosine biosynthetic process + +[Term] +id: GO:0006170 +name: dAMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732] +synonym: "dAMP anabolism" EXACT [] +synonym: "dAMP biosynthesis" EXACT [] +synonym: "dAMP formation" EXACT [] +synonym: "dAMP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046053 ! dAMP metabolic process + +[Term] +id: GO:0006171 +name: cAMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] +synonym: "3',5' cAMP biosynthesis" EXACT [] +synonym: "3',5' cAMP biosynthetic process" EXACT [] +synonym: "3',5'-cAMP biosynthesis" EXACT [] +synonym: "3',5'-cAMP biosynthetic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "cAMP anabolism" EXACT [] +synonym: "cAMP biosynthesis" EXACT [] +synonym: "cAMP formation" EXACT [] +synonym: "cAMP synthesis" EXACT [] +synonym: "cyclic AMP biosynthesis" EXACT [] +synonym: "cyclic AMP biosynthetic process" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0046058 ! cAMP metabolic process +is_a: GO:0052652 ! cyclic purine nucleotide metabolic process + +[Term] +id: GO:0006172 +name: ADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] +synonym: "ADP anabolism" EXACT [] +synonym: "ADP biosynthesis" EXACT [] +synonym: "ADP formation" EXACT [] +synonym: "ADP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0006173 +name: dADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732] +synonym: "dADP anabolism" EXACT [] +synonym: "dADP biosynthesis" EXACT [] +synonym: "dADP formation" EXACT [] +synonym: "dADP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0006174 +name: dADP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0006175 +name: dATP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732] +synonym: "dATP anabolism" EXACT [] +synonym: "dATP biosynthesis" EXACT [] +synonym: "dATP formation" EXACT [] +synonym: "dATP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046060 ! dATP metabolic process + +[Term] +id: GO:0006176 +name: dATP biosynthetic process from ADP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732] +synonym: "dATP anabolism from ADP" EXACT [] +synonym: "dATP formation from ADP" EXACT [] +synonym: "dATP synthesis from ADP" EXACT [] +is_a: GO:0006175 ! dATP biosynthetic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0006177 +name: GMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] +synonym: "GMP anabolism" EXACT [] +synonym: "GMP biosynthesis" EXACT [] +synonym: "GMP formation" EXACT [] +synonym: "GMP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046037 ! GMP metabolic process + +[Term] +id: GO:0006178 +name: guanine salvage +namespace: biological_process +def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] +is_a: GO:0043096 ! purine nucleobase salvage +is_a: GO:0046099 ! guanine biosynthetic process + +[Term] +id: GO:0006179 +name: guanosine salvage +namespace: biological_process +def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0046114 ! guanosine biosynthetic process + +[Term] +id: GO:0006180 +name: deoxyguanosine salvage +namespace: biological_process +def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0043098 ! purine deoxyribonucleoside salvage + +[Term] +id: GO:0006181 +name: dGMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732] +synonym: "dGMP anabolism" EXACT [] +synonym: "dGMP biosynthesis" EXACT [] +synonym: "dGMP formation" EXACT [] +synonym: "dGMP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0046054 ! dGMP metabolic process + +[Term] +id: GO:0006182 +name: cGMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] +synonym: "cGMP anabolism" EXACT [] +synonym: "cGMP biosynthesis" EXACT [] +synonym: "cGMP formation" EXACT [] +synonym: "cGMP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0046068 ! cGMP metabolic process +is_a: GO:0052652 ! cyclic purine nucleotide metabolic process + +[Term] +id: GO:0006183 +name: GTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] +synonym: "GTP anabolism" EXACT [] +synonym: "GTP biosynthesis" EXACT [] +synonym: "GTP formation" EXACT [] +synonym: "GTP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046039 ! GTP metabolic process + +[Term] +id: GO:0006184 +name: obsolete GTP catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "GTP breakdown" EXACT [] +synonym: "GTP catabolism" EXACT [] +synonym: "GTP degradation" EXACT [] +synonym: "GTP hydrolysis" NARROW [] +is_obsolete: true +consider: GO:0003924 + +[Term] +id: GO:0006185 +name: dGDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732] +synonym: "dGDP anabolism" EXACT [] +synonym: "dGDP biosynthesis" EXACT [] +synonym: "dGDP formation" EXACT [] +synonym: "dGDP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0006186 +name: dGDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0006187 +name: dGTP biosynthetic process from dGDP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732] +synonym: "dGTP anabolism from dGDP" EXACT [] +synonym: "dGTP formation from dGDP" EXACT [] +synonym: "dGTP synthesis from dGDP" EXACT [] +is_a: GO:0046066 ! dGDP metabolic process +is_a: GO:0046071 ! dGTP biosynthetic process + +[Term] +id: GO:0006188 +name: IMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] +synonym: "IMP anabolism" EXACT [] +synonym: "IMP biosynthesis" EXACT [] +synonym: "IMP formation" EXACT [] +synonym: "IMP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006189 +name: 'de novo' IMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] +synonym: "'de novo' IMP anabolism" EXACT [] +synonym: "'de novo' IMP biosynthesis" EXACT [] +synonym: "'de novo' IMP formation" EXACT [] +synonym: "'de novo' IMP synthesis" EXACT [] +synonym: "'de novo' purine biosynthesis" BROAD [] +synonym: "'de novo' purine biosynthetic process" BROAD [] +is_a: GO:0006188 ! IMP biosynthetic process + +[Term] +id: GO:0006190 +name: inosine salvage +namespace: biological_process +def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] +synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] +is_a: GO:0006166 ! purine ribonucleoside salvage +is_a: GO:0046103 ! inosine biosynthetic process + +[Term] +id: GO:0006191 +name: deoxyinosine salvage +namespace: biological_process +def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0043098 ! purine deoxyribonucleoside salvage +is_a: GO:0046095 ! deoxyinosine biosynthetic process + +[Term] +id: GO:0006192 +name: IDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0006193 +name: ITP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732] +synonym: "ITP breakdown" EXACT [] +synonym: "ITP catabolism" EXACT [] +synonym: "ITP degradation" EXACT [] +synonym: "ITP hydrolysis" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process +is_a: GO:0046041 ! ITP metabolic process + +[Term] +id: GO:0006194 +name: dIDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process + +[Term] +id: GO:0006195 +name: purine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleotide breakdown" EXACT [] +synonym: "purine nucleotide catabolism" EXACT [] +synonym: "purine nucleotide degradation" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process + +[Term] +id: GO:0006196 +name: AMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732] +synonym: "AMP breakdown" EXACT [] +synonym: "AMP catabolism" EXACT [] +synonym: "AMP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046033 ! AMP metabolic process + +[Term] +id: GO:0006197 +name: obsolete adenylate deaminase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "adenylate deaminase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0003876 + +[Term] +id: GO:0006198 +name: cAMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] +synonym: "3',5' cAMP catabolic process" EXACT [] +synonym: "3',5' cAMP catabolism" EXACT [] +synonym: "3',5'-cAMP catabolic process" EXACT [] +synonym: "3',5'-cAMP catabolism" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "cAMP breakdown" EXACT [] +synonym: "cAMP catabolism" EXACT [] +synonym: "cAMP degradation" EXACT [] +synonym: "cyclic AMP catabolic process" EXACT [] +synonym: "cyclic AMP catabolism" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009214 ! cyclic nucleotide catabolic process +is_a: GO:0046058 ! cAMP metabolic process + +[Term] +id: GO:0006199 +name: obsolete ADP reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "ADP reduction" EXACT [] +is_obsolete: true +consider: GO:0051061 + +[Term] +id: GO:0006200 +name: obsolete ATP catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "ATP breakdown" EXACT [] +synonym: "ATP catabolism" EXACT [] +synonym: "ATP degradation" EXACT [] +synonym: "ATP hydrolysis" NARROW [] +xref: Wikipedia:ATP_hydrolysis +is_obsolete: true +consider: GO:0016887 + +[Term] +id: GO:0006201 +name: GMP catabolic process to IMP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732] +synonym: "GMP breakdown to IMP" EXACT [] +synonym: "GMP degradation to IMP" EXACT [] +is_a: GO:0046038 ! GMP catabolic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006202 +name: GMP catabolic process to guanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732] +synonym: "GMP breakdown to guanine" EXACT [] +synonym: "GMP degradation to guanine" EXACT [] +is_a: GO:0046038 ! GMP catabolic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0006203 +name: dGTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732] +synonym: "dGTP breakdown" EXACT [] +synonym: "dGTP catabolism" EXACT [] +synonym: "dGTP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046070 ! dGTP metabolic process + +[Term] +id: GO:0006204 +name: IMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732] +synonym: "IMP breakdown" EXACT [] +synonym: "IMP catabolism" EXACT [] +synonym: "IMP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046040 ! IMP metabolic process + +[Term] +id: GO:0006205 +name: obsolete pyrimidine metabolic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "pyrimidine metabolic process" EXACT [] +is_obsolete: true +consider: GO:0006206 +consider: GO:0006213 +consider: GO:0006220 + +[Term] +id: GO:0006206 +name: pyrimidine nucleobase metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +synonym: "pyrimidine base metabolic process" EXACT [GOC:go_curators] +synonym: "pyrimidine base metabolism" EXACT [] +synonym: "pyrimidine metabolic process" RELATED [] +synonym: "pyrimidine metabolism" RELATED [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:0006207 +name: 'de novo' pyrimidine nucleobase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] +synonym: "'de novo' pyrimidine base anabolism" EXACT [] +synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] +synonym: "'de novo' pyrimidine base biosynthetic process" EXACT [GOC:go_curators] +synonym: "'de novo' pyrimidine base formation" EXACT [] +synonym: "'de novo' pyrimidine base synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process + +[Term] +id: GO:0006208 +name: pyrimidine nucleobase catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +synonym: "pyrimidine base breakdown" EXACT [] +synonym: "pyrimidine base catabolic process" EXACT [GOC:go_curators] +synonym: "pyrimidine base catabolism" EXACT [] +synonym: "pyrimidine base degradation" EXACT [] +is_a: GO:0006206 ! pyrimidine nucleobase metabolic process +is_a: GO:0046113 ! nucleobase catabolic process +is_a: GO:0072529 ! pyrimidine-containing compound catabolic process + +[Term] +id: GO:0006209 +name: cytosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] +synonym: "cytosine breakdown" EXACT [] +synonym: "cytosine catabolism" EXACT [] +synonym: "cytosine degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine nucleobase catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019858 ! cytosine metabolic process + +[Term] +id: GO:0006210 +name: thymine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +synonym: "thymine breakdown" EXACT [] +synonym: "thymine catabolism" EXACT [] +synonym: "thymine degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine nucleobase catabolic process +is_a: GO:0019859 ! thymine metabolic process + +[Term] +id: GO:0006211 +name: 5-methylcytosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] +synonym: "5-methylcytosine breakdown" EXACT [] +synonym: "5-methylcytosine catabolism" EXACT [] +synonym: "5-methylcytosine degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019857 ! 5-methylcytosine metabolic process +is_a: GO:0072529 ! pyrimidine-containing compound catabolic process + +[Term] +id: GO:0006212 +name: uracil catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +synonym: "uracil breakdown" EXACT [] +synonym: "uracil catabolism" EXACT [] +synonym: "uracil degradation" EXACT [] +is_a: GO:0006208 ! pyrimidine nucleobase catabolic process +is_a: GO:0019860 ! uracil metabolic process + +[Term] +id: GO:0006213 +name: pyrimidine nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +synonym: "pyrimidine metabolic process" BROAD [] +synonym: "pyrimidine metabolism" BROAD [] +synonym: "pyrimidine nucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:0006214 +name: thymidine catabolic process +namespace: biological_process +alt_id: GO:0006215 +def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +synonym: "deoxyribosylthymine catabolic process" EXACT [] +synonym: "deoxyribosylthymine catabolism" EXACT [] +synonym: "thymidine breakdown" EXACT [] +synonym: "thymidine catabolism" EXACT [] +synonym: "thymidine degradation" EXACT [] +is_a: GO:0046104 ! thymidine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006216 +name: cytidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] +synonym: "cytidine breakdown" EXACT [] +synonym: "cytidine catabolism" EXACT [] +synonym: "cytidine degradation" EXACT [] +is_a: GO:0046087 ! cytidine metabolic process +is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process + +[Term] +id: GO:0006217 +name: deoxycytidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxycytidine breakdown" EXACT [] +synonym: "deoxycytidine catabolism" EXACT [] +synonym: "deoxycytidine degradation" EXACT [] +is_a: GO:0046092 ! deoxycytidine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006218 +name: uridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +synonym: "uridine breakdown" EXACT [] +synonym: "uridine catabolism" EXACT [] +synonym: "uridine degradation" EXACT [] +is_a: GO:0046108 ! uridine metabolic process +is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process + +[Term] +id: GO:0006219 +name: deoxyuridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyuridine breakdown" EXACT [] +synonym: "deoxyuridine catabolism" EXACT [] +synonym: "deoxyuridine degradation" EXACT [] +is_a: GO:0046096 ! deoxyuridine metabolic process +is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process + +[Term] +id: GO:0006220 +name: pyrimidine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine metabolic process" BROAD [] +synonym: "pyrimidine metabolism" BROAD [] +synonym: "pyrimidine nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:0006221 +name: pyrimidine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleotide anabolism" EXACT [] +synonym: "pyrimidine nucleotide biosynthesis" EXACT [] +synonym: "pyrimidine nucleotide formation" EXACT [] +synonym: "pyrimidine nucleotide synthesis" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process + +[Term] +id: GO:0006222 +name: UMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] +synonym: "UMP anabolism" EXACT [] +synonym: "UMP biosynthesis" EXACT [] +synonym: "UMP formation" EXACT [] +synonym: "UMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046049 ! UMP metabolic process + +[Term] +id: GO:0006223 +name: uracil salvage +namespace: biological_process +def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] +is_a: GO:0043100 ! pyrimidine nucleobase salvage +is_a: GO:0046107 ! uracil biosynthetic process + +[Term] +id: GO:0006224 +name: obsolete uridine kinase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "uridine kinase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0004849 + +[Term] +id: GO:0006225 +name: UDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] +synonym: "UDP anabolism" EXACT [] +synonym: "UDP biosynthesis" EXACT [] +synonym: "UDP formation" EXACT [] +synonym: "UDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046048 ! UDP metabolic process + +[Term] +id: GO:0006226 +name: dUMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732] +synonym: "dUMP anabolism" EXACT [] +synonym: "dUMP biosynthesis" EXACT [] +synonym: "dUMP formation" EXACT [] +synonym: "dUMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046078 ! dUMP metabolic process + +[Term] +id: GO:0006227 +name: dUDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732] +synonym: "dUDP anabolism" EXACT [] +synonym: "dUDP biosynthesis" EXACT [] +synonym: "dUDP formation" EXACT [] +synonym: "dUDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046077 ! dUDP metabolic process + +[Term] +id: GO:0006228 +name: UTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] +synonym: "UTP anabolism" EXACT [] +synonym: "UTP biosynthesis" EXACT [] +synonym: "UTP formation" EXACT [] +synonym: "UTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046051 ! UTP metabolic process + +[Term] +id: GO:0006229 +name: dUTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732] +synonym: "dUTP anabolism" EXACT [] +synonym: "dUTP biosynthesis" EXACT [] +synonym: "dUTP formation" EXACT [] +synonym: "dUTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046080 ! dUTP metabolic process + +[Term] +id: GO:0006230 +name: TMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732] +synonym: "TMP anabolism" EXACT [] +synonym: "TMP biosynthesis" EXACT [] +synonym: "TMP formation" EXACT [] +synonym: "TMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046044 ! TMP metabolic process + +[Term] +id: GO:0006231 +name: dTMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] +synonym: "dTMP anabolism" EXACT [] +synonym: "dTMP biosynthesis" EXACT [] +synonym: "dTMP formation" EXACT [] +synonym: "dTMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046073 ! dTMP metabolic process + +[Term] +id: GO:0006232 +name: TDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732] +synonym: "TDP anabolism" EXACT [] +synonym: "TDP biosynthesis" EXACT [] +synonym: "TDP formation" EXACT [] +synonym: "TDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046043 ! TDP metabolic process + +[Term] +id: GO:0006233 +name: dTDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732] +synonym: "dTDP anabolism" EXACT [] +synonym: "dTDP biosynthesis" EXACT [] +synonym: "dTDP formation" EXACT [] +synonym: "dTDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046072 ! dTDP metabolic process + +[Term] +id: GO:0006234 +name: TTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732] +synonym: "TTP anabolism" EXACT [] +synonym: "TTP biosynthesis" EXACT [] +synonym: "TTP formation" EXACT [] +synonym: "TTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046046 ! TTP metabolic process + +[Term] +id: GO:0006235 +name: dTTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732] +synonym: "dTTP anabolism" EXACT [] +synonym: "dTTP biosynthesis" EXACT [] +synonym: "dTTP formation" EXACT [] +synonym: "dTTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046075 ! dTTP metabolic process + +[Term] +id: GO:0006236 +name: cytidine salvage +namespace: biological_process +def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] +is_a: GO:0043097 ! pyrimidine nucleoside salvage +is_a: GO:0046088 ! cytidine biosynthetic process + +[Term] +id: GO:0006237 +name: deoxycytidine salvage +namespace: biological_process +def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage +is_a: GO:0046093 ! deoxycytidine biosynthetic process + +[Term] +id: GO:0006238 +name: CMP salvage +namespace: biological_process +def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "cytidine monophosphate salvage" EXACT [] +is_a: GO:0009224 ! CMP biosynthetic process +is_a: GO:0010138 ! pyrimidine ribonucleotide salvage + +[Term] +id: GO:0006239 +name: dCMP salvage +namespace: biological_process +def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] +synonym: "deoxycytidine monophosphate salvage" EXACT [] +is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage +is_a: GO:0046064 ! dCMP biosynthetic process + +[Term] +id: GO:0006240 +name: dCDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] +synonym: "dCDP anabolism" EXACT [] +synonym: "dCDP biosynthesis" EXACT [] +synonym: "dCDP formation" EXACT [] +synonym: "dCDP synthesis" EXACT [] +is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046062 ! dCDP metabolic process + +[Term] +id: GO:0006241 +name: CTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] +synonym: "CTP anabolism" EXACT [] +synonym: "CTP biosynthesis" EXACT [] +synonym: "CTP formation" EXACT [] +synonym: "CTP synthesis" EXACT [] +is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046036 ! CTP metabolic process + +[Term] +id: GO:0006242 +name: dCTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] +synonym: "dCTP anabolism" EXACT [] +synonym: "dCTP biosynthesis" EXACT [] +synonym: "dCTP formation" EXACT [] +synonym: "dCTP synthesis" EXACT [] +is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046065 ! dCTP metabolic process + +[Term] +id: GO:0006244 +name: pyrimidine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleotide breakdown" EXACT [] +synonym: "pyrimidine nucleotide catabolism" EXACT [] +synonym: "pyrimidine nucleotide degradation" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0072529 ! pyrimidine-containing compound catabolic process + +[Term] +id: GO:0006245 +name: TDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732] +synonym: "TDP breakdown" EXACT [] +synonym: "TDP catabolism" EXACT [] +synonym: "TDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046043 ! TDP metabolic process + +[Term] +id: GO:0006246 +name: dTDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732] +synonym: "dTDP breakdown" EXACT [] +synonym: "dTDP catabolism" EXACT [] +synonym: "dTDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046072 ! dTDP metabolic process + +[Term] +id: GO:0006247 +name: obsolete TTP reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "TTP reduction" EXACT [] +is_obsolete: true +consider: GO:0051064 + +[Term] +id: GO:0006248 +name: CMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732] +synonym: "CMP breakdown" EXACT [] +synonym: "CMP catabolism" EXACT [] +synonym: "CMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046035 ! CMP metabolic process + +[Term] +id: GO:0006249 +name: dCMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732] +synonym: "dCMP breakdown" EXACT [] +synonym: "dCMP catabolism" EXACT [] +synonym: "dCMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046063 ! dCMP metabolic process + +[Term] +id: GO:0006250 +name: obsolete CDP reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "CDP reduction" EXACT [] +is_obsolete: true +consider: GO:0051063 + +[Term] +id: GO:0006251 +name: dCDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] +synonym: "dCDP breakdown" EXACT [] +synonym: "dCDP catabolism" EXACT [] +synonym: "dCDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046062 ! dCDP metabolic process + +[Term] +id: GO:0006252 +name: obsolete CTP reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "CTP reduction" EXACT [] +is_obsolete: true +consider: GO:0051065 + +[Term] +id: GO:0006253 +name: dCTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] +synonym: "dCTP breakdown" EXACT [] +synonym: "dCTP catabolism" EXACT [] +synonym: "dCTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046065 ! dCTP metabolic process + +[Term] +id: GO:0006254 +name: CTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] +synonym: "CTP breakdown" EXACT [] +synonym: "CTP catabolism" EXACT [] +synonym: "CTP degradation" EXACT [] +synonym: "CTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046036 ! CTP metabolic process + +[Term] +id: GO:0006255 +name: obsolete UDP reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "UDP reduction" EXACT [] +is_obsolete: true +consider: GO:0051062 + +[Term] +id: GO:0006256 +name: UDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] +synonym: "UDP breakdown" EXACT [] +synonym: "UDP catabolism" EXACT [] +synonym: "UDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046048 ! UDP metabolic process + +[Term] +id: GO:0006257 +name: dUDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732] +synonym: "dUDP breakdown" EXACT [] +synonym: "dUDP catabolism" EXACT [] +synonym: "dUDP degradation" EXACT [] +is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046077 ! dUDP metabolic process + +[Term] +id: GO:0006258 +name: UDP-glucose catabolic process +namespace: biological_process +alt_id: GO:0019691 +def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-glucose breakdown" EXACT [] +synonym: "UDP-glucose catabolism" EXACT [] +synonym: "UDP-glucose conversion" RELATED [] +synonym: "UDP-glucose degradation" EXACT [] +is_a: GO:0006011 ! UDP-glucose metabolic process +is_a: GO:0009227 ! nucleotide-sugar catabolic process + +[Term] +id: GO:0006259 +name: DNA metabolic process +namespace: biological_process +alt_id: GO:0055132 +def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "cellular DNA metabolism" EXACT [] +synonym: "DNA metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process +is_a: GO:0090304 ! nucleic acid metabolic process + +[Term] +id: GO:0006260 +name: DNA replication +namespace: biological_process +alt_id: GO:0055133 +def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] +comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +xref: Wikipedia:DNA_replication +is_a: GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:0006261 +name: DNA-dependent DNA replication +namespace: biological_process +alt_id: GO:0006262 +alt_id: GO:0006263 +def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] +is_a: GO:0006260 ! DNA replication + +[Term] +id: GO:0006264 +name: mitochondrial DNA replication +namespace: biological_process +def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] +synonym: "mitochondrial DNA synthesis" RELATED [] +synonym: "mtDNA replication" EXACT [] +synonym: "mtDNA synthesis" RELATED [] +synonym: "replication of mitochondrial DNA" EXACT [] +is_a: GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006265 +name: DNA topological change +namespace: biological_process +def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] +comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. +synonym: "DNA underwinding" NARROW [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0071103 ! DNA conformation change + +[Term] +id: GO:0006266 +name: DNA ligation +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0006267 +name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle] +synonym: "nuclear pre-replicative complex assembly" EXACT [] +synonym: "pre-RC complex assembly" BROAD [] +synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2] +synonym: "pre-replicative complex formation" BROAD [] +is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:0006268 +name: DNA unwinding involved in DNA replication +namespace: biological_process +def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] +comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. +synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb] +synonym: "DNA unwinding factor" RELATED [] +is_a: GO:0032508 ! DNA duplex unwinding +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006269 +name: DNA replication, synthesis of RNA primer +namespace: biological_process +def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] +synonym: "replication priming" RELATED [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006270 +name: DNA replication initiation +namespace: biological_process +alt_id: GO:0042024 +def: "The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate." [ISBN:071673706X, ISBN:0815316194, PMID:28209641] +synonym: "DNA endoreduplication initiation" NARROW [] +synonym: "DNA re-replication initiation" NARROW [] +synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006271 +name: DNA strand elongation involved in DNA replication +namespace: biological_process +def: "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] +synonym: "DNA replication elongation" EXACT [] +synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022616 ! DNA strand elongation +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006272 +name: leading strand elongation +namespace: biological_process +def: "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] +is_a: GO:0006271 ! DNA strand elongation involved in DNA replication + +[Term] +id: GO:0006273 +name: lagging strand elongation +namespace: biological_process +def: "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] +is_a: GO:0006271 ! DNA strand elongation involved in DNA replication + +[Term] +id: GO:0006274 +name: DNA replication termination +namespace: biological_process +def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0006275 +name: regulation of DNA replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0006276 +name: plasmid maintenance +namespace: biological_process +def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0006277 +name: DNA amplification +namespace: biological_process +def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] +is_a: GO:0071897 ! DNA biosynthetic process + +[Term] +id: GO:0006278 +name: RNA-dependent DNA biosynthetic process +namespace: biological_process +def: "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] +is_a: GO:0071897 ! DNA biosynthetic process + +[Term] +id: GO:0006279 +name: premeiotic DNA replication +namespace: biological_process +alt_id: GO:1902968 +def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie] +synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "meiotic cell cycle DNA replication" EXACT [] +synonym: "meiotic DNA replication" RELATED [GOC:mah] +synonym: "meiotic DNA synthesis" RELATED [GOC:mah] +synonym: "meiotic nuclear cell cycle DNA replication" EXACT [] +synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT [] +synonym: "premeiotic DNA synthesis" RELATED [GOC:mah] +is_a: GO:0033260 ! nuclear DNA replication +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0006280 +name: obsolete mutagenesis +namespace: biological_process +def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732] +comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. +synonym: "mutagenesis" EXACT [] +is_obsolete: true +consider: GO:0006281 +consider: GO:0051276 + +[Term] +id: GO:0006281 +name: DNA repair +namespace: biological_process +def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +xref: Wikipedia:DNA_repair +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0006282 +name: regulation of DNA repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] +subset: goslim_metagenomics +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0006283 +name: transcription-coupled nucleotide-excision repair +namespace: biological_process +def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] +synonym: "TC-NER" EXACT [PMID:10197977] +synonym: "TCR" RELATED [GOC:vw, PMID:18794354] +synonym: "transcription-coupled NER" EXACT [GOC:mah] +synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354] +is_a: GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006284 +name: base-excision repair +namespace: biological_process +def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] +synonym: "BER" EXACT [] +xref: Wikipedia:Base_excision_repair +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006285 +name: base-excision repair, AP site formation +namespace: biological_process +def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006286 +name: obsolete base-excision repair, base-free sugar-phosphate removal +namespace: biological_process +def: "OBSOLETE. Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0003906 +consider: GO:0017108 + +[Term] +id: GO:0006287 +name: base-excision repair, gap-filling +namespace: biological_process +def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006288 +name: base-excision repair, DNA ligation +namespace: biological_process +def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] +is_a: GO:0051103 ! DNA ligation involved in DNA repair +relationship: part_of GO:0006284 ! base-excision repair + +[Term] +id: GO:0006289 +name: nucleotide-excision repair +namespace: biological_process +alt_id: GO:0045001 +def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] +comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. +synonym: "intrastrand cross-link repair" RELATED [] +synonym: "NER" EXACT [] +synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006290 +name: pyrimidine dimer repair +namespace: biological_process +def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006291 +name: obsolete pyrimidine-dimer repair, DNA damage excision +namespace: biological_process +def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] +comment: This term was made obsolete because this process can be subdivided into multiple processes. +synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] +is_obsolete: true +consider: GO:0006289 + +[Term] +id: GO:0006292 +name: obsolete pyrimidine-dimer repair, DNA damage recognition +namespace: biological_process +def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] +comment: This term was made obsolete because it is a substrate specific DNA repair process. +synonym: "pyrimidine-dimer repair, DNA damage recognition" EXACT [] +is_obsolete: true +consider: GO:0000715 +consider: GO:0000716 + +[Term] +id: GO:0006293 +name: nucleotide-excision repair, preincision complex stabilization +namespace: biological_process +def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006294 +name: nucleotide-excision repair, preincision complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] +synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006295 +name: nucleotide-excision repair, DNA incision, 3'-to lesion +namespace: biological_process +def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] +synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] +is_a: GO:0033683 ! nucleotide-excision repair, DNA incision + +[Term] +id: GO:0006296 +name: nucleotide-excision repair, DNA incision, 5'-to lesion +namespace: biological_process +def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] +synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] +is_a: GO:0033683 ! nucleotide-excision repair, DNA incision + +[Term] +id: GO:0006297 +name: nucleotide-excision repair, DNA gap filling +namespace: biological_process +def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0006298 +name: mismatch repair +namespace: biological_process +alt_id: GO:0006300 +def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] +synonym: "long patch mismatch repair system" NARROW [] +synonym: "mismatch repair, MutL-like pathway" RELATED [] +synonym: "MMR" EXACT [] +synonym: "MutS/MutL/MutH pathway" RELATED [] +xref: Wikipedia:DNA_mismatch_repair +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006299 +name: obsolete short patch mismatch repair system +namespace: biological_process +def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] +comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. +synonym: "short patch mismatch repair system" EXACT [] +is_obsolete: true +consider: GO:0006284 +consider: GO:0006289 + +[Term] +id: GO:0006301 +name: postreplication repair +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] +synonym: "postreplication DNA repair" EXACT [] +xref: Wikipedia:Postreplication_repair +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006302 +name: double-strand break repair +namespace: biological_process +def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] +comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0006303 +name: double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] +synonym: "NHEJ" EXACT [] +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0006304 +name: DNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0043412 ! macromolecule modification + +[Term] +id: GO:0006305 +name: DNA alkylation +namespace: biological_process +def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0006306 +name: DNA methylation +namespace: biological_process +def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] +xref: Wikipedia:DNA_methylation +is_a: GO:0006305 ! DNA alkylation +is_a: GO:0043414 ! macromolecule methylation +is_a: GO:0044728 ! DNA methylation or demethylation + +[Term] +id: GO:0006307 +name: DNA dealkylation involved in DNA repair +namespace: biological_process +def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] +is_a: GO:0035510 ! DNA dealkylation +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:0006308 +name: DNA catabolic process +namespace: biological_process +def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] +synonym: "DNA breakdown" EXACT [] +synonym: "DNA catabolism" EXACT [] +synonym: "DNA degradation" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0034655 ! nucleobase-containing compound catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0006309 +name: apoptotic DNA fragmentation +namespace: biological_process +alt_id: GO:0008178 +def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] +comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). +synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis] +synonym: "DNA catabolic process during apoptosis" EXACT [] +synonym: "DNA catabolism during apoptosis" EXACT [] +synonym: "DNA fragmentation" BROAD [] +synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb] +synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] +is_a: GO:0000737 ! DNA catabolic process, endonucleolytic +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0006310 +name: DNA recombination +namespace: biological_process +def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0006311 +name: meiotic gene conversion +namespace: biological_process +def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] +synonym: "gene conversion without reciprocal crossover" EXACT [] +is_a: GO:0035822 ! gene conversion +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0006312 +name: mitotic recombination +namespace: biological_process +def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles." [GOC:elh] +xref: Wikipedia:Mitotic_crossover +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0006313 +name: transposition, DNA-mediated +namespace: biological_process +alt_id: GO:0006317 +alt_id: GO:0006318 +def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] +synonym: "Class II transposition" EXACT [] +synonym: "DNA transposition" EXACT [GOC:dph] +synonym: "P-element excision" NARROW [] +synonym: "P-element transposition" NARROW [] +synonym: "Tc1/mariner transposition" NARROW [] +synonym: "Tc3 transposition" NARROW [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0006314 +name: intron homing +namespace: biological_process +def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0006315 +name: homing of group II introns +namespace: biological_process +def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] +is_a: GO:0006314 ! intron homing + +[Term] +id: GO:0006316 +name: movement of group I intron +namespace: biological_process +def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] +is_a: GO:0006314 ! intron homing + +[Term] +id: GO:0006323 +name: DNA packaging +namespace: biological_process +def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +synonym: "DNA condensation" EXACT [] +synonym: "DNA organisation" EXACT [] +synonym: "DNA organization" EXACT [] +is_a: GO:0071103 ! DNA conformation change + +[Term] +id: GO:0006324 +name: obsolete S phase-specific histone modification +namespace: biological_process +def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] +comment: This term was made obsolete because histone modification already exists and the phase specificity is better captured as an annotation extension. +synonym: "S phase-specific histone modification" EXACT [] +synonym: "S-phase-specific histone modification" EXACT [] +is_obsolete: true +consider: GO:0016570 + +[Term] +id: GO:0006325 +name: chromatin organization +namespace: biological_process +alt_id: GO:0016568 +def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah, GOC:vw, PMID:20404130] +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "chromatin modification" RELATED [] +synonym: "chromatin organisation" EXACT [GOC:mah] +synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0051276 ! chromosome organization + +[Term] +id: GO:0006326 +name: obsolete bent DNA binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "bent DNA binding" EXACT [] +is_obsolete: true +replaced_by: GO:0003681 + +[Term] +id: GO:0006327 +name: obsolete random coil binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "random coil binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006328 +name: obsolete AT binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "AT binding" EXACT [] +is_obsolete: true +replaced_by: GO:0003680 + +[Term] +id: GO:0006329 +name: obsolete satellite DNA binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "satellite DNA binding" EXACT [] +is_obsolete: true +replaced_by: GO:0003696 + +[Term] +id: GO:0006330 +name: obsolete single-stranded DNA binding +namespace: biological_process +alt_id: GO:0006331 +alt_id: GO:0006332 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "single-stranded DNA binding" EXACT [] +is_obsolete: true +replaced_by: GO:0003697 + +[Term] +id: GO:0006333 +name: chromatin assembly or disassembly +namespace: biological_process +def: "The formation or destruction of chromatin structures." [GOC:mah] +synonym: "chromatin assembly/disassembly" EXACT [] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0006334 +name: nucleosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] +synonym: "histone chaperone" RELATED [GOC:vw] +synonym: "nucleosome modeling" EXACT [] +is_a: GO:0034728 ! nucleosome organization +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0031497 ! chromatin assembly + +[Term] +id: GO:0006335 +name: DNA replication-dependent chromatin assembly +namespace: biological_process +def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] +synonym: "DNA replication-dependent nucleosome assembly" EXACT [] +is_a: GO:0031497 ! chromatin assembly +is_a: GO:0034723 ! DNA replication-dependent chromatin organization + +[Term] +id: GO:0006336 +name: DNA replication-independent chromatin assembly +namespace: biological_process +def: "The formation of chromatin outside the context of DNA replication." [GOC:mah] +synonym: "DNA replication-independent nucleosome assembly" EXACT [] +synonym: "transcription-coupled nucleosome assembly" EXACT [] +is_a: GO:0031497 ! chromatin assembly +is_a: GO:0034724 ! DNA replication-independent chromatin organization + +[Term] +id: GO:0006337 +name: nucleosome disassembly +namespace: biological_process +def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] +is_a: GO:0032986 ! protein-DNA complex disassembly +is_a: GO:0034728 ! nucleosome organization +relationship: part_of GO:0031498 ! chromatin disassembly + +[Term] +id: GO:0006338 +name: chromatin remodeling +namespace: biological_process +alt_id: GO:0043044 +def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] +synonym: "ATP-dependent chromatin remodeling" NARROW [] +synonym: "ATP-dependent chromatin remodelling" NARROW [] +synonym: "chromatin modeling" EXACT [] +synonym: "chromatin modelling" EXACT [] +synonym: "chromatin remodelling" EXACT [] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0006339 +name: obsolete positive regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "positive regulation of transcription of homeotic gene (trithorax group)" EXACT [] +is_obsolete: true +consider: GO:0031507 +consider: GO:0045815 +consider: GO:0045944 + +[Term] +id: GO:0006340 +name: obsolete negative regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "negative regulation of transcription of homeotic gene (Polycomb group)" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0031507 +consider: GO:0045815 + +[Term] +id: GO:0006341 +name: obsolete chromatin insulator sequence binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "chromatin insulator sequence binding" EXACT [] +is_obsolete: true +replaced_by: GO:0043035 + +[Term] +id: GO:0006346 +name: DNA methylation-dependent heterochromatin assembly +namespace: biological_process +def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] +synonym: "methylation-dependent chromatin silencing" BROAD [] +synonym: "methylation-dependent heterochromatic silencing" BROAD [] +is_a: GO:0140718 ! facultative heterochromatin assembly + +[Term] +id: GO:0006349 +name: regulation of gene expression by genomic imprinting +namespace: biological_process +def: "An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles." [PMID:11498578, PMID:31896690, PMID:7502071] +synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah] +synonym: "regulation of gene expression by genetic imprinting" RELATED [] +xref: Wikipedia:Genomic_imprinting +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0006351 +name: transcription, DNA-templated +namespace: biological_process +alt_id: GO:0001121 +alt_id: GO:0006350 +alt_id: GO:0061018 +alt_id: GO:0061022 +def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] +subset: goslim_aspergillus +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_pombe +synonym: "bacterial transcription" NARROW [] +synonym: "cellular transcription" BROAD [] +synonym: "DNA-dependent transcription" EXACT [] +synonym: "transcription" BROAD [] +synonym: "transcription from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] +xref: Wikipedia:Transcription_(genetics) +is_a: GO:0097659 ! nucleic acid-templated transcription + +[Term] +id: GO:0006352 +name: DNA-templated transcription, initiation +namespace: biological_process +alt_id: GO:0001123 +def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] +comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. +subset: goslim_yeast +synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT [] +synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH] +synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah] +synonym: "transcription initiation factor activity" RELATED [] +synonym: "transcription initiation from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006353 +name: DNA-templated transcription, termination +namespace: biological_process +alt_id: GO:0001125 +def: "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] +subset: goslim_yeast +synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH] +synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah] +synonym: "transcription termination factor activity" RELATED [] +synonym: "transcription termination from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2] +synonym: "transcriptional complex disassembly" BROAD [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006354 +name: DNA-templated transcription, elongation +namespace: biological_process +alt_id: GO:0001124 +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] +subset: goslim_pir +subset: goslim_yeast +synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH] +synonym: "RNA elongation" BROAD [] +synonym: "RNA elongation from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcription elongation from bacterial-type RNA polymerase promoter" NARROW [] +synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2] +synonym: "transcriptional elongation, DNA-dependent" EXACT [] +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006355 +name: regulation of transcription, DNA-templated +namespace: biological_process +alt_id: GO:0032583 +alt_id: GO:0045449 +alt_id: GO:0061019 +def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +subset: goslim_drosophila +subset: goslim_generic +synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] +synonym: "regulation of gene-specific transcription" RELATED [] +synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] +synonym: "transcriptional control" BROAD [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:1903506 ! regulation of nucleic acid-templated transcription +relationship: regulates GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006356 +name: regulation of transcription by RNA polymerase I +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] +synonym: "regulation of transcription from Pol I promoter" EXACT [] +synonym: "regulation of transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0006357 +name: regulation of transcription by RNA polymerase II +namespace: biological_process +alt_id: GO:0006358 +alt_id: GO:0010551 +def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] +synonym: "global transcription regulation from Pol II promoter" RELATED [] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] +synonym: "regulation of global transcription from Pol II promoter" RELATED [] +synonym: "regulation of transcription from Pol II promoter" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0006359 +name: regulation of transcription by RNA polymerase III +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III." [GOC:go_curators] +synonym: "regulation of transcription from Pol III promoter" EXACT [] +synonym: "regulation of transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0006360 +name: transcription by RNA polymerase I +namespace: biological_process +def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] +subset: goslim_yeast +synonym: "RNA polymerase I transcription factor activity" RELATED [] +synonym: "transcription from Pol I promoter" EXACT [] +synonym: "transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006361 +name: transcription initiation from RNA polymerase I promoter +namespace: biological_process +alt_id: GO:0001180 +def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] +comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. +synonym: "transcription initiation from Pol I promoter" EXACT [] +synonym: "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW [] +is_a: GO:0006352 ! DNA-templated transcription, initiation +relationship: part_of GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0006362 +name: transcription elongation from RNA polymerase I promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH] +synonym: "RNA elongation from Pol I promoter" EXACT [] +synonym: "RNA polymerase I transcription elongation factor activity" RELATED [] +is_a: GO:0006354 ! DNA-templated transcription, elongation +relationship: part_of GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0006363 +name: termination of RNA polymerase I transcription +namespace: biological_process +alt_id: GO:0001185 +alt_id: GO:0019223 +def: "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922] +synonym: "RNA polymerase I transcription termination" EXACT [] +synonym: "RNA polymerase I transcription termination factor activity" RELATED [] +synonym: "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript" NARROW [] +synonym: "transcription termination from Pol I promoter" EXACT [] +synonym: "transcription termination from RNA polymerase I promoter" EXACT [] +is_a: GO:0006353 ! DNA-templated transcription, termination +relationship: part_of GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0006364 +name: rRNA processing +namespace: biological_process +alt_id: GO:0006365 +def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] +subset: goslim_yeast +synonym: "35S primary transcript processing" NARROW [] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0006366 +name: transcription by RNA polymerase II +namespace: biological_process +alt_id: GO:0032568 +alt_id: GO:0032569 +def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] +subset: goslim_yeast +synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] +synonym: "general transcription from RNA polymerase II promoter" RELATED [] +synonym: "RNA polymerase II transcription factor activity" RELATED [] +synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] +synonym: "transcription from Pol II promoter" EXACT [] +synonym: "transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006367 +name: transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] +comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. +synonym: "transcription initiation from Pol II promoter" EXACT [] +is_a: GO:0006352 ! DNA-templated transcription, initiation +relationship: part_of GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0006368 +name: transcription elongation from RNA polymerase II promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] +synonym: "RNA elongation from Pol II promoter" EXACT [] +synonym: "RNA polymerase II transcription elongation factor activity" RELATED [] +is_a: GO:0006354 ! DNA-templated transcription, elongation +relationship: part_of GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0006369 +name: termination of RNA polymerase II transcription +namespace: biological_process +alt_id: GO:0019224 +def: "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah, GOC:txnOH] +synonym: "RNA 3'-end formation by RNA polymerase II" EXACT [] +synonym: "RNA polymerase II transcription termination" EXACT [] +synonym: "RNA polymerase II transcription termination factor activity" RELATED [] +synonym: "transcription termination from Pol II promoter" EXACT [] +synonym: "transcription termination from RNA polymerase II promoter" EXACT [] +is_a: GO:0006353 ! DNA-templated transcription, termination +relationship: part_of GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0006370 +name: 7-methylguanosine mRNA capping +namespace: biological_process +def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] +synonym: "5' end capping" BROAD [] +synonym: "5' mRNA capping" EXACT [] +synonym: "5'-end mRNA processing" EXACT [] +synonym: "5'-end processing" BROAD [] +synonym: "mRNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] +is_a: GO:0006397 ! mRNA processing +is_a: GO:0009452 ! 7-methylguanosine RNA capping + +[Term] +id: GO:0006371 +name: obsolete mRNA splicing +namespace: biological_process +def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732] +comment: This term was made obsolete because it represents several different processes. +synonym: "mRNA splicing" EXACT [] +is_obsolete: true +consider: GO:0000372 +consider: GO:0000373 +consider: GO:0000374 +consider: GO:0000394 +consider: GO:0000398 + +[Term] +id: GO:0006372 +name: obsolete lariat formation, 5'-splice site cleavage +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a molecular function. +synonym: "lariat formation, 5'-splice site cleavage" EXACT [] +is_obsolete: true +consider: GO:0000350 +consider: GO:0000386 + +[Term] +id: GO:0006373 +name: obsolete 3'-splice site cleavage, exon ligation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it represents a molecular function. +synonym: "3'-splice site cleavage, exon ligation" EXACT [] +is_obsolete: true +consider: GO:0000386 +consider: GO:0000388 +consider: GO:0000393 + +[Term] +id: GO:0006376 +name: mRNA splice site selection +namespace: biological_process +def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] +synonym: "spliceosomal commitment complex biosynthesis" NARROW [] +synonym: "spliceosomal commitment complex formation" NARROW [] +synonym: "spliceosomal E complex biosynthesis" NARROW [] +synonym: "spliceosomal E complex formation" NARROW [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000245 ! spliceosomal complex assembly + +[Term] +id: GO:0006377 +name: obsolete MATa1 (A1) pre-mRNA splicing +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. +synonym: "MATa1 (A1) pre-mRNA splicing" EXACT [] +is_obsolete: true +consider: GO:0000244 + +[Term] +id: GO:0006378 +name: mRNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] +synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] +synonym: "mRNA polyadenylylation" EXACT [] +is_a: GO:0031124 ! mRNA 3'-end processing +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0006379 +name: mRNA cleavage +namespace: biological_process +def: "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] +synonym: "cleavage stimulation factor activity" RELATED [] +is_a: GO:0016071 ! mRNA metabolic process +is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis + +[Term] +id: GO:0006380 +name: obsolete poly-A binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "poly-A binding" EXACT [] +is_obsolete: true +consider: GO:0008143 + +[Term] +id: GO:0006382 +name: adenosine to inosine editing +namespace: biological_process +def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0006383 +name: transcription by RNA polymerase III +namespace: biological_process +alt_id: GO:0001009 +alt_id: GO:0001035 +alt_id: GO:0001041 +def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659] +subset: goslim_yeast +synonym: "RNA polymerase III transcription factor activity" RELATED [] +synonym: "transcription from a RNA polymerase III hybrid type promoter" NARROW [] +synonym: "transcription from Pol III promoter" EXACT [] +synonym: "transcription from RNA polymerase III promoter" EXACT [] +synonym: "transcription from RNA polymerase III type 2 promoter" NARROW [] +synonym: "transcription from RNA polymerase III type 3 promoter" NARROW [] +synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW [] +synonym: "U6 snRNA transcription (mammalian)" NARROW [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0006384 +name: transcription initiation from RNA polymerase III promoter +namespace: biological_process +alt_id: GO:0001022 +alt_id: GO:0001023 +alt_id: GO:0001024 +alt_id: GO:0001036 +def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] +comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. +synonym: "transcription initiation from Pol III promoter" EXACT [] +synonym: "transcription initiation from RNA polymerase III hybrid type promoter" NARROW [] +synonym: "transcription initiation from RNA polymerase III type 1 promoter" NARROW [] +synonym: "transcription initiation from RNA polymerase III type 2 promoter" NARROW [] +synonym: "transcription initiation from RNA polymerase III type 3 promoter" NARROW [] +is_a: GO:0006352 ! DNA-templated transcription, initiation +relationship: part_of GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0006385 +name: transcription elongation from RNA polymerase III promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH] +synonym: "RNA elongation from Pol III promoter" EXACT [] +synonym: "RNA polymerase III transcription elongation factor activity" RELATED [] +is_a: GO:0006354 ! DNA-templated transcription, elongation +relationship: part_of GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0006386 +name: termination of RNA polymerase III transcription +namespace: biological_process +alt_id: GO:0019225 +def: "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] +synonym: "RNA polymerase III transcription termination" EXACT [] +synonym: "RNA polymerase III transcription termination factor activity" RELATED [] +synonym: "transcription termination from Pol III promoter" EXACT [] +synonym: "transcription termination from RNA polymerase III promoter" EXACT [] +is_a: GO:0006353 ! DNA-templated transcription, termination +relationship: part_of GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0006387 +name: obsolete snRNA capping +namespace: biological_process +def: "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah] +comment: This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. +synonym: "snRNA capping" EXACT [] +is_obsolete: true +consider: GO:0036261 + +[Term] +id: GO:0006388 +name: tRNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] +comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +synonym: "tRNA-Y splicing" NARROW [] +is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation +is_a: GO:0008033 ! tRNA processing + +[Term] +id: GO:0006389 +name: obsolete tRNA-Y splicing +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. +synonym: "tRNA-Y splicing" EXACT [] +is_obsolete: true +consider: GO:0006388 + +[Term] +id: GO:0006390 +name: mitochondrial transcription +namespace: biological_process +def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] +synonym: "transcription from mitochondrial promoter" EXACT [] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006351 ! transcription, DNA-templated +relationship: part_of GO:0140053 ! mitochondrial gene expression + +[Term] +id: GO:0006391 +name: transcription initiation from mitochondrial promoter +namespace: biological_process +def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006352 ! DNA-templated transcription, initiation +relationship: part_of GO:0006390 ! mitochondrial transcription + +[Term] +id: GO:0006392 +name: transcription elongation from mitochondrial promoter +namespace: biological_process +def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH] +synonym: "RNA elongation from mitochondrial promoter" EXACT [] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006354 ! DNA-templated transcription, elongation +relationship: part_of GO:0006390 ! mitochondrial transcription + +[Term] +id: GO:0006393 +name: termination of mitochondrial transcription +namespace: biological_process +def: "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] +synonym: "mitochondrial transcription termination" EXACT [] +synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006353 ! DNA-templated transcription, termination +relationship: part_of GO:0006390 ! mitochondrial transcription + +[Term] +id: GO:0006396 +name: RNA processing +namespace: biological_process +alt_id: GO:0006394 +def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] +subset: goslim_drosophila +subset: goslim_pir +xref: Wikipedia:Post-transcriptional_modification +is_a: GO:0016070 ! RNA metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006397 +name: mRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] +subset: goslim_chembl +subset: goslim_yeast +synonym: "mRNA maturation" RELATED [] +is_a: GO:0006396 ! RNA processing +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0006398 +name: mRNA 3'-end processing by stem-loop binding and cleavage +namespace: biological_process +def: "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288] +synonym: "histone mRNA 3' end processing" NARROW [] +is_a: GO:0008334 ! histone mRNA metabolic process +is_a: GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0006399 +name: tRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "tRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0006400 +name: tRNA modification +namespace: biological_process +alt_id: GO:0016549 +def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +synonym: "tRNA editing" NARROW [GOC:hjd] +is_a: GO:0008033 ! tRNA processing +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0006401 +name: RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] +subset: goslim_yeast +synonym: "RNA breakdown" EXACT [] +synonym: "RNA catabolism" EXACT [] +synonym: "RNA degradation" EXACT [] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0034655 ! nucleobase-containing compound catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0006402 +name: mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] +synonym: "mRNA breakdown" EXACT [] +synonym: "mRNA catabolism" EXACT [] +synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] +synonym: "mRNA degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0006403 +name: RNA localization +namespace: biological_process +def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] +subset: goslim_drosophila +synonym: "establishment and maintenance of RNA localization" EXACT [] +synonym: "RNA localisation" EXACT [GOC:mah] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0006404 +name: RNA import into nucleus +namespace: biological_process +def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] +synonym: "RNA import into cell nucleus" EXACT [] +synonym: "RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "RNA-nucleus import" EXACT [] +is_a: GO:0050658 ! RNA transport +is_a: GO:0051170 ! import into nucleus + +[Term] +id: GO:0006405 +name: RNA export from nucleus +namespace: biological_process +def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "RNA export from cell nucleus" EXACT [] +synonym: "RNA export out of nucleus" EXACT [] +synonym: "RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "RNA-nucleus export" EXACT [] +is_a: GO:0050658 ! RNA transport +is_a: GO:0051168 ! nuclear export + +[Term] +id: GO:0006406 +name: mRNA export from nucleus +namespace: biological_process +def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "mRNA export from cell nucleus" EXACT [] +synonym: "mRNA export out of nucleus" EXACT [] +synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "mRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +is_a: GO:0051028 ! mRNA transport +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006407 +name: rRNA export from nucleus +namespace: biological_process +def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah] +synonym: "rRNA export from cell nucleus" EXACT [] +synonym: "rRNA export out of nucleus" EXACT [] +synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "rRNA-nucleus export" EXACT [] +is_a: GO:0051029 ! rRNA transport +is_a: GO:0097064 ! ncRNA export from nucleus +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0006408 +name: snRNA export from nucleus +namespace: biological_process +def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "snRNA export from cell nucleus" EXACT [] +synonym: "snRNA export out of nucleus" EXACT [] +synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "snRNA-nucleus export" EXACT [] +is_a: GO:0051030 ! snRNA transport +is_a: GO:0097064 ! ncRNA export from nucleus + +[Term] +id: GO:0006409 +name: tRNA export from nucleus +namespace: biological_process +def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "tRNA export from cell nucleus" EXACT [] +synonym: "tRNA export out of nucleus" EXACT [] +synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "tRNA-nucleus export" EXACT [] +is_a: GO:0051031 ! tRNA transport +is_a: GO:0097064 ! ncRNA export from nucleus + +[Term] +id: GO:0006410 +name: obsolete transcription, RNA-dependent +namespace: biological_process +def: "OBSOLETE. The cellular synthesis of DNA on a template of RNA." [GOC:jl] +comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis. +synonym: "transcription, RNA-dependent" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006412 +name: translation +namespace: biological_process +alt_id: GO:0006416 +alt_id: GO:0006453 +alt_id: GO:0043037 +def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "protein anabolism" EXACT [] +synonym: "protein biosynthesis" EXACT [] +synonym: "protein biosynthetic process" EXACT [] +synonym: "protein formation" EXACT [] +synonym: "protein synthesis" EXACT [] +synonym: "protein translation" EXACT [] +xref: Wikipedia:Translation_(genetics) +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0044267 ! cellular protein metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0006413 +name: translational initiation +namespace: biological_process +alt_id: GO:0006440 +alt_id: GO:0006454 +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] +subset: goslim_yeast +synonym: "biopolymerisation" BROAD [] +synonym: "biopolymerization" BROAD [] +synonym: "protein synthesis initiation" BROAD [] +synonym: "translation initiation" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006414 +name: translational elongation +namespace: biological_process +alt_id: GO:0006442 +alt_id: GO:0006455 +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] +subset: goslim_yeast +synonym: "protein synthesis elongation" BROAD [] +synonym: "translation elongation" EXACT [] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006415 +name: translational termination +namespace: biological_process +alt_id: GO:0006443 +alt_id: GO:0006456 +def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] +synonym: "protein synthesis termination" BROAD [] +synonym: "translation termination" EXACT [] +synonym: "translational complex disassembly" EXACT [] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006417 +name: regulation of translation +namespace: biological_process +alt_id: GO:0006445 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] +subset: goslim_yeast +synonym: "regulation of protein anabolism" EXACT [] +synonym: "regulation of protein biosynthesis" EXACT [] +synonym: "regulation of protein formation" EXACT [] +synonym: "regulation of protein synthesis" EXACT [] +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0006412 ! translation + +[Term] +id: GO:0006418 +name: tRNA aminoacylation for protein translation +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] +subset: goslim_yeast +synonym: "tRNA charging" NARROW [] +xref: MetaCyc:TRNA-CHARGING-PWY +is_a: GO:0043039 ! tRNA aminoacylation +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0006419 +name: alanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006420 +name: arginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006421 +name: asparaginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006422 +name: aspartyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA." [GOC:mah, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006423 +name: cysteinyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006424 +name: glutamyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006425 +name: glutaminyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006426 +name: glycyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006427 +name: histidyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006428 +name: isoleucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006429 +name: leucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006430 +name: lysyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006431 +name: methionyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006432 +name: phenylalanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006433 +name: prolyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA." [GOC:mah, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006434 +name: seryl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006435 +name: threonyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006436 +name: tryptophanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006437 +name: tyrosyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006438 +name: valyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] +is_a: GO:0006418 ! tRNA aminoacylation for protein translation + +[Term] +id: GO:0006439 +name: obsolete aminoacyl-tRNA hydrolase reaction +namespace: biological_process +def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] +comment: This term was made obsolete because it represents a molecular function. +synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0004045 + +[Term] +id: GO:0006441 +name: obsolete binding to mRNA cap +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "binding to mRNA cap" EXACT [] +is_obsolete: true +consider: GO:0000339 + +[Term] +id: GO:0006446 +name: regulation of translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] +is_a: GO:0006417 ! regulation of translation +relationship: regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0006447 +name: regulation of translational initiation by iron +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] +is_a: GO:0006446 ! regulation of translational initiation + +[Term] +id: GO:0006448 +name: regulation of translational elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] +is_a: GO:0006417 ! regulation of translation +relationship: regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0006449 +name: regulation of translational termination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +relationship: regulates GO:0006415 ! translational termination + +[Term] +id: GO:0006450 +name: regulation of translational fidelity +namespace: biological_process +alt_id: GO:0000029 +def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +synonym: "regulation of translational accuracy" EXACT [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0006451 +name: translational readthrough +namespace: biological_process +def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232] +synonym: "natural nonsense suppression" RELATED [] +is_a: GO:0006414 ! translational elongation +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0006452 +name: translational frameshifting +namespace: biological_process +def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] +xref: Wikipedia:Translational_frameshift +is_a: GO:0006414 ! translational elongation + +[Term] +id: GO:0006457 +name: protein folding +namespace: biological_process +alt_id: GO:0007022 +alt_id: GO:0007024 +alt_id: GO:0007025 +def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +synonym: "alpha-tubulin folding" NARROW [GOC:mah] +synonym: "beta-tubulin folding" NARROW [GOC:mah] +synonym: "chaperone activity" RELATED [] +synonym: "chaperonin ATPase activity" RELATED [] +synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] +synonym: "co-chaperone activity" RELATED [] +synonym: "co-chaperonin activity" RELATED [] +synonym: "glycoprotein-specific chaperone activity" RELATED [] +synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] +synonym: "protein complex assembly, multichaperone pathway" RELATED [] +xref: Wikipedia:Protein_folding +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0006458 +name: 'de novo' protein folding +namespace: biological_process +def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] +synonym: "nascent chain protein folding" EXACT [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0006459 +name: obsolete binding unfolded ER proteins +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "binding unfolded ER proteins" EXACT [] +is_obsolete: true +consider: GO:0005783 +consider: GO:0051082 + +[Term] +id: GO:0006460 +name: obsolete peptidyl-prolyl isomerase B reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "peptidyl-prolyl isomerase B reaction" EXACT [] +is_obsolete: true +consider: GO:0003755 + +[Term] +id: GO:0006462 +name: obsolete protein complex assembly, multichaperone pathway +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. +synonym: "protein complex assembly, multichaperone pathway" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051131 + +[Term] +id: GO:0006463 +name: steroid hormone receptor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0006464 +name: cellular protein modification process +namespace: biological_process +def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_pir +subset: goslim_plant +synonym: "process resulting in protein modification" RELATED [] +synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] +synonym: "protein tagging activity" RELATED [] +is_a: GO:0036211 ! protein modification process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006465 +name: signal peptide processing +namespace: biological_process +def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] +synonym: "leader peptide processing" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0016485 ! protein processing +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006466 +name: obsolete protein disulfide-isomerase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it presents a molecular function. +synonym: "protein disulfide-isomerase reaction" EXACT [] +synonym: "protein disulphide-isomerase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0003756 + +[Term] +id: GO:0006468 +name: protein phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group on to a protein." [GOC:hb] +subset: goslim_yeast +synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0006469 +name: negative regulation of protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +synonym: "down regulation of protein kinase activity" EXACT [] +synonym: "down-regulation of protein kinase activity" EXACT [] +synonym: "downregulation of protein kinase activity" EXACT [] +synonym: "inhibition of protein kinase activity" NARROW [] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0006470 +name: protein dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] +subset: goslim_yeast +synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0016311 ! dephosphorylation + +[Term] +id: GO:0006471 +name: protein ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] +synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf] +xref: RESID:AA0040 +xref: RESID:AA0168 +xref: RESID:AA0169 +xref: RESID:AA0231 +xref: RESID:AA0237 +xref: RESID:AA0295 +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0006473 +name: protein acetylation +namespace: biological_process +def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +synonym: "protein amino acid acetylation" EXACT [GOC:bf] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0006474 +name: N-terminal protein amino acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] +synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267] +is_a: GO:0006473 ! protein acetylation +is_a: GO:0031365 ! N-terminal protein amino acid modification +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0006475 +name: internal protein amino acid acetylation +namespace: biological_process +def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] +is_a: GO:0006473 ! protein acetylation + +[Term] +id: GO:0006476 +name: protein deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +synonym: "protein amino acid deacetylation" EXACT [GOC:bf] +is_a: GO:0035601 ! protein deacylation + +[Term] +id: GO:0006477 +name: protein sulfation +namespace: biological_process +def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators] +synonym: "protein amino acid sulfation" EXACT [GOC:bf] +synonym: "protein amino acid sulphation" EXACT [] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0051923 ! sulfation + +[Term] +id: GO:0006478 +name: peptidyl-tyrosine sulfation +namespace: biological_process +def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] +synonym: "peptidyl-tyrosine sulphation" EXACT [] +xref: RESID:AA0172 +is_a: GO:0006477 ! protein sulfation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0006479 +name: protein methylation +namespace: biological_process +def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] +synonym: "protein amino acid methylation" EXACT [GOC:bf] +is_a: GO:0008213 ! protein alkylation +is_a: GO:0043414 ! macromolecule methylation + +[Term] +id: GO:0006480 +name: N-terminal protein amino acid methylation +namespace: biological_process +def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] +is_a: GO:0006479 ! protein methylation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0006481 +name: C-terminal protein methylation +namespace: biological_process +def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] +synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf] +is_a: GO:0006479 ! protein methylation +is_a: GO:0018410 ! C-terminal protein amino acid modification + +[Term] +id: GO:0006482 +name: protein demethylation +namespace: biological_process +def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] +synonym: "protein amino acid demethylation" EXACT [GOC:bf] +is_a: GO:0008214 ! protein dealkylation +is_a: GO:0070988 ! demethylation + +[Term] +id: GO:0006483 +name: obsolete peptidyl-aspartic acid/asparagine hydroxylation +namespace: biological_process +def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +synonym: "aspartic acid/asparagine hydroxylation" EXACT [] +synonym: "peptidyl-aspartic acid/asparagine hydroxylation" EXACT [] +is_obsolete: true +consider: GO:0042264 +consider: GO:0042265 + +[Term] +id: GO:0006484 +name: obsolete protein cysteine-thiol oxidation +namespace: biological_process +def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] +comment: This term was made obsolete because it represents a single activity. +synonym: "protein cysteine-thiol oxidation" EXACT [] +is_obsolete: true +consider: GO:0003756 + +[Term] +id: GO:0006486 +name: protein glycosylation +namespace: biological_process +alt_id: GO:0065006 +def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "protein amino acid glycosylation" EXACT [GOC:bf] +synonym: "protein-carbohydrate complex assembly" RELATED [] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0043413 ! macromolecule glycosylation +relationship: part_of GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0006487 +name: protein N-linked glycosylation +namespace: biological_process +def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] +synonym: "N-glycan biosynthesis" RELATED [] +synonym: "N-glycan metabolism" RELATED [] +synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] +xref: RESID:AA0151 +xref: RESID:AA0156 +xref: RESID:AA0327 +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0006488 +name: dolichol-linked oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309] +synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] +synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] +synonym: "dolichol-linked oligosaccharide formation" EXACT [] +synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] +synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161] +synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161] +synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] +is_a: GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process +relationship: part_of GO:0006487 ! protein N-linked glycosylation + +[Term] +id: GO:0006489 +name: dolichyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732] +synonym: "dolichyl diphosphate anabolism" EXACT [] +synonym: "dolichyl diphosphate biosynthesis" EXACT [] +synonym: "dolichyl diphosphate formation" EXACT [] +synonym: "dolichyl diphosphate synthesis" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0046465 ! dolichyl diphosphate metabolic process +relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process + +[Term] +id: GO:0006490 +name: oligosaccharide-lipid intermediate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb] +synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr] +is_a: GO:0044255 ! cellular lipid metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0006491 +name: N-glycan processing +namespace: biological_process +alt_id: GO:0006492 +def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] +synonym: "glycoprotein trimming involved in glycoprotein maturation" NARROW [] +synonym: "N-linked glycoprotein maturation" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0006493 +name: protein O-linked glycosylation +namespace: biological_process +def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] +synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf] +xref: RESID:AA0153 +xref: RESID:AA0154 +xref: RESID:AA0155 +xref: RESID:AA0157 +xref: RESID:AA0212 +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0006494 +name: obsolete protein amino acid terminal glycosylation +namespace: biological_process +def: "OBSOLETE. A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] +comment: This term was made obsolete because the term name is ambiguous. +synonym: "protein amino acid terminal glycosylation" EXACT [] +is_obsolete: true +consider: GO:0006486 + +[Term] +id: GO:0006495 +name: obsolete terminal O-glycosylation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] +comment: This term was made obsolete because there is no evidence for the existence of this process. +synonym: "terminal O-glycosylation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006496 +name: obsolete protein amino acid terminal N-glycosylation +namespace: biological_process +def: "OBSOLETE. The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] +comment: This term was made obsolete because the term name is ambiguous. +synonym: "protein amino acid terminal N-glycosylation" EXACT [] +is_obsolete: true +consider: GO:0006487 +consider: GO:0035629 + +[Term] +id: GO:0006497 +name: protein lipidation +namespace: biological_process +alt_id: GO:0042050 +def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] +comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. +subset: goslim_drosophila +subset: goslim_yeast +synonym: "lipid:protein modification" EXACT [] +synonym: "protein amino acid lipidation" EXACT [GOC:bf] +xref: RESID:AA0059 +xref: RESID:AA0060 +xref: RESID:AA0077 +xref: RESID:AA0078 +xref: RESID:AA0079 +xref: RESID:AA0080 +xref: RESID:AA0102 +xref: RESID:AA0103 +xref: RESID:AA0104 +xref: RESID:AA0106 +xref: RESID:AA0107 +xref: RESID:AA0158 +xref: RESID:AA0159 +xref: RESID:AA0160 +xref: RESID:AA0161 +xref: RESID:AA0162 +xref: RESID:AA0163 +xref: RESID:AA0166 +xref: RESID:AA0223 +xref: RESID:AA0290 +xref: RESID:AA0307 +xref: RESID:AA0308 +xref: RESID:AA0309 +xref: RESID:AA0316 +is_a: GO:0006464 ! cellular protein modification process +relationship: part_of GO:0042158 ! lipoprotein biosynthetic process + +[Term] +id: GO:0006498 +name: N-terminal protein lipidation +namespace: biological_process +def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0006499 +name: N-terminal protein myristoylation +namespace: biological_process +def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] +is_a: GO:0006498 ! N-terminal protein lipidation +is_a: GO:0018377 ! protein myristoylation + +[Term] +id: GO:0006500 +name: N-terminal protein palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] +is_a: GO:0006498 ! N-terminal protein lipidation +is_a: GO:0018345 ! protein palmitoylation + +[Term] +id: GO:0006501 +name: C-terminal protein lipidation +namespace: biological_process +def: "The covalent attachment of a lipid group to the carboxy-terminus of a protein." [GOC:jl] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0018410 ! C-terminal protein amino acid modification + +[Term] +id: GO:0006502 +name: obsolete C-terminal protein prenylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy-terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. +synonym: "C-terminal protein prenylation" EXACT [] +is_obsolete: true +replaced_by: GO:0018342 + +[Term] +id: GO:0006503 +name: obsolete C-terminal protein farnesylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. +synonym: "C-terminal protein farnesylation" EXACT [] +is_obsolete: true +replaced_by: GO:0018343 + +[Term] +id: GO:0006504 +name: obsolete C-terminal protein geranylgeranylation +namespace: biological_process +def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy-terminus of a protein." [GOC:jl] +comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. +synonym: "C-terminal protein geranylgeranylation" EXACT [] +is_obsolete: true +replaced_by: GO:0018344 + +[Term] +id: GO:0006505 +name: GPI anchor metabolic process +namespace: biological_process +alt_id: GO:0046472 +def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732] +synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] +synonym: "glycosylphosphatidylinositol metabolism" EXACT [] +synonym: "GPI anchor metabolism" EXACT [] +synonym: "GPI/GSI anchor metabolic process" BROAD [] +synonym: "GPI/GSI anchor metabolism" BROAD [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:0006506 +name: GPI anchor biosynthetic process +namespace: biological_process +alt_id: GO:0015998 +def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] +synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] +synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] +synonym: "GPI anchor anabolism" EXACT [] +synonym: "GPI anchor biosynthesis" EXACT [] +synonym: "GPI anchor formation" EXACT [] +synonym: "GPI anchor synthesis" EXACT [] +synonym: "GPI/GSI anchor biosynthesis" BROAD [] +synonym: "GPI/GSI anchor biosynthetic process" BROAD [] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0006505 ! GPI anchor metabolic process +is_a: GO:0006661 ! phosphatidylinositol biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process + +[Term] +id: GO:0006507 +name: GPI anchor release +namespace: biological_process +def: "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934] +is_a: GO:0006505 ! GPI anchor metabolic process + +[Term] +id: GO:0006508 +name: proteolysis +namespace: biological_process +def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] +comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] +synonym: "peptidolysis" EXACT [] +xref: Wikipedia:Proteolysis +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:0006509 +name: membrane protein ectodomain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] +synonym: "ectoderm shedding" BROAD [GOC:pm, PMID:12096138, PMID:15672459, PMID:18419754] +synonym: "ectodomain cleavage" EXACT [PMID:18757500] +synonym: "membrane protein solubilization" RELATED [] +synonym: "receptor shedding" RELATED [] +is_a: GO:0033619 ! membrane protein proteolysis + +[Term] +id: GO:0006510 +name: obsolete ATP-dependent proteolysis +namespace: biological_process +def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] +comment: This term was made obsolete because it represents a molecular function. +synonym: "ATP-dependent peptidolysis" EXACT [] +synonym: "ATP-dependent proteolysis" EXACT [] +is_obsolete: true +replaced_by: GO:0004176 +consider: GO:0006508 +consider: GO:0016485 +consider: GO:0051603 + +[Term] +id: GO:0006511 +name: ubiquitin-dependent protein catabolic process +namespace: biological_process +alt_id: GO:0042787 +alt_id: GO:0043432 +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] +synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] +synonym: "protein degradation tagging activity" BROAD [] +synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] +synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] +synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] +synonym: "protein ubiquitination involved in ubiquitin-dependent protein catabolic process" RELATED [] +synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [] +synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [] +synonym: "ubiquitin-dependent protein breakdown" EXACT [] +synonym: "ubiquitin-dependent protein catabolism" EXACT [] +synonym: "ubiquitin-dependent protein degradation" EXACT [] +synonym: "ubiquitin-dependent proteolysis" EXACT [] +is_a: GO:0019941 ! modification-dependent protein catabolic process + +[Term] +id: GO:0006512 +name: obsolete ubiquitin cycle +namespace: biological_process +def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] +comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. +synonym: "ubiquitin cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006513 +name: protein monoubiquitination +namespace: biological_process +def: "Addition of a single ubiquitin group to a protein." [GOC:ai] +synonym: "protein monoubiquitinylation" EXACT [] +synonym: "protein monoubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0006515 +name: protein quality control for misfolded or incompletely synthesized proteins +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] +synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] +synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] +synonym: "misfolded or incompletely synthesized protein catabolic process" EXACT [] +synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] +synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] +synonym: "protein quality control (PQC)" EXACT [] +synonym: "protein quality control by the ubiquitin-proteasome system" BROAD [] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0006516 +name: glycoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +synonym: "glycoprotein breakdown" EXACT [] +synonym: "glycoprotein catabolism" EXACT [] +synonym: "glycoprotein degradation" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0006517 +name: protein deglycosylation +namespace: biological_process +def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] +synonym: "glycoprotein deglycosylation" EXACT [] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0006518 +name: peptide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators] +subset: goslim_pir +synonym: "peptide metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006520 +name: cellular amino acid metabolic process +namespace: biological_process +alt_id: GO:0006519 +def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +synonym: "amino acid and derivative metabolism" EXACT [] +synonym: "amino acid metabolic process" EXACT [] +synonym: "cellular amino acid and derivative metabolic process" EXACT [] +synonym: "cellular amino acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0044238 ! primary metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006521 +name: regulation of cellular amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] +synonym: "regulation of amino acid metabolism" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0006522 +name: alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] +synonym: "alanine metabolism" EXACT [] +is_a: GO:0009078 ! pyruvate family amino acid metabolic process + +[Term] +id: GO:0006523 +name: alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] +synonym: "alanine anabolism" EXACT [] +synonym: "alanine biosynthesis" EXACT [] +synonym: "alanine formation" EXACT [] +synonym: "alanine synthesis" EXACT [] +is_a: GO:0006522 ! alanine metabolic process +is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process + +[Term] +id: GO:0006524 +name: alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] +synonym: "alanine breakdown" EXACT [] +synonym: "alanine catabolism" EXACT [] +synonym: "alanine degradation" EXACT [] +is_a: GO:0006522 ! alanine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009080 ! pyruvate family amino acid catabolic process + +[Term] +id: GO:0006525 +name: arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] +synonym: "arginine metabolism" EXACT [] +xref: Wikipedia:Arginine +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006526 +name: arginine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ISBN:0198506732] +synonym: "arginine anabolism" EXACT [] +synonym: "arginine biosynthesis" EXACT [] +synonym: "arginine formation" EXACT [] +synonym: "arginine synthesis" EXACT [] +xref: MetaCyc:ARGININE-SYN4-PWY +xref: MetaCyc:ARGSYN-PWY +xref: MetaCyc:ARGSYNBSUB-PWY +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006527 +name: arginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:go_curators] +synonym: "arginine breakdown" EXACT [] +synonym: "arginine catabolism" EXACT [] +synonym: "arginine degradation" EXACT [] +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006528 +name: asparagine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +synonym: "asparagine metabolism" EXACT [] +xref: MetaCyc:ASPARAGINESYN-PWY +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006529 +name: asparagine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +synonym: "asparagine anabolism" EXACT [] +synonym: "asparagine biosynthesis" EXACT [] +synonym: "asparagine formation" EXACT [] +synonym: "asparagine synthesis" EXACT [] +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0006530 +name: asparagine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] +synonym: "asparagine breakdown" EXACT [] +synonym: "asparagine catabolism" EXACT [] +synonym: "asparagine degradation" EXACT [] +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006531 +name: aspartate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] +synonym: "aspartate metabolism" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006532 +name: aspartate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] +synonym: "aspartate anabolism" EXACT [] +synonym: "aspartate biosynthesis" EXACT [] +synonym: "aspartate formation" EXACT [] +synonym: "aspartate synthesis" EXACT [] +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0006533 +name: aspartate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] +synonym: "aspartate breakdown" EXACT [] +synonym: "aspartate catabolism" EXACT [] +synonym: "aspartate degradation" EXACT [] +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0006534 +name: cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +synonym: "cysteine metabolism" EXACT [] +xref: Wikipedia:Cysteine_metabolism +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006535 +name: cysteine biosynthetic process from serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] +synonym: "cysteine anabolism from serine" EXACT [] +synonym: "cysteine formation from serine" EXACT [] +synonym: "cysteine synthesis from serine" EXACT [] +xref: MetaCyc:CYSTSYN-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0006536 +name: glutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +synonym: "glutamate metabolism" EXACT [] +synonym: "glutamic acid metabolic process" EXACT [] +synonym: "glutamic acid metabolism" EXACT [] +xref: Wikipedia:Glutamic_acid +is_a: GO:0009064 ! glutamine family amino acid metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0006537 +name: glutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +synonym: "glutamate anabolism" EXACT [] +synonym: "glutamate biosynthesis" EXACT [] +synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] +synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] +synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] +synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] +synonym: "glutamate formation" EXACT [] +synonym: "glutamate synthesis" EXACT [] +synonym: "glutamic acid biosynthesis" EXACT [] +synonym: "glutamic acid biosynthetic process" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0006538 +name: glutamate catabolic process +namespace: biological_process +alt_id: GO:0019459 +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] +synonym: "glutamate breakdown" EXACT [] +synonym: "glutamate catabolism" EXACT [] +synonym: "glutamate deamidation" RELATED [] +synonym: "glutamate degradation" EXACT [] +synonym: "glutamic acid catabolic process" EXACT [] +synonym: "glutamic acid catabolism" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0006539 +name: glutamate catabolic process via 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] +synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] +synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] +synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] +synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] +xref: MetaCyc:P162-PWY +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0006540 +name: glutamate decarboxylation to succinate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] +comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively). +synonym: "4-aminobutyrate shunt" EXACT [] +synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY] +synonym: "GABA shunt" EXACT [] +synonym: "gamma-aminobutyrate shunt" EXACT [] +synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY] +synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY] +xref: MetaCyc:GLUDEG-I-PWY +xref: MetaCyc:PWY-4321 +xref: MetaCyc:PWY3O-210 +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0006541 +name: glutamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +synonym: "glutamine metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006542 +name: glutamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +synonym: "glutamine anabolism" EXACT [] +synonym: "glutamine biosynthesis" EXACT [] +synonym: "glutamine formation" EXACT [] +synonym: "glutamine synthesis" EXACT [] +xref: MetaCyc:GLNSYN-PWY +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006543 +name: glutamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] +synonym: "glutamine breakdown" EXACT [] +synonym: "glutamine catabolism" EXACT [] +synonym: "glutamine degradation" EXACT [] +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006544 +name: glycine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] +synonym: "glycine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006545 +name: glycine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] +synonym: "glycine anabolism" EXACT [] +synonym: "glycine biosynthesis" EXACT [] +synonym: "glycine formation" EXACT [] +synonym: "glycine synthesis" EXACT [] +xref: MetaCyc:GLYCINE-SYN2-PWY +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0006546 +name: glycine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] +synonym: "glycine breakdown" EXACT [] +synonym: "glycine catabolism" EXACT [] +synonym: "glycine degradation" EXACT [] +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0006547 +name: histidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +synonym: "histidine metabolism" EXACT [] +xref: Wikipedia:Histidine +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0006548 +name: histidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] +synonym: "histidine breakdown" EXACT [] +synonym: "histidine catabolism" EXACT [] +synonym: "histidine degradation" EXACT [] +is_a: GO:0006547 ! histidine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process + +[Term] +id: GO:0006549 +name: isoleucine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +synonym: "isoleucine metabolism" EXACT [] +is_a: GO:0009081 ! branched-chain amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006550 +name: isoleucine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +synonym: "isoleucine breakdown" EXACT [] +synonym: "isoleucine catabolism" EXACT [] +synonym: "isoleucine degradation" EXACT [] +xref: MetaCyc:ILEUDEG-PWY +is_a: GO:0006549 ! isoleucine metabolic process +is_a: GO:0009083 ! branched-chain amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006551 +name: leucine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +synonym: "leucine metabolism" EXACT [] +is_a: GO:0009081 ! branched-chain amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006552 +name: leucine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +synonym: "leucine breakdown" EXACT [] +synonym: "leucine catabolism" EXACT [] +synonym: "leucine degradation" EXACT [] +xref: MetaCyc:LEU-DEG2-PWY +is_a: GO:0006551 ! leucine metabolic process +is_a: GO:0009083 ! branched-chain amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006553 +name: lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +synonym: "lysine metabolism" EXACT [] +xref: Wikipedia:Lysine +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006554 +name: lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +synonym: "lysine breakdown" EXACT [] +synonym: "lysine catabolism" EXACT [] +synonym: "lysine degradation" EXACT [] +is_a: GO:0006553 ! lysine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006555 +name: methionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "methionine and threonine metabolic process" BROAD [] +synonym: "methionine and threonine metabolism" BROAD [] +synonym: "methionine metabolism" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006556 +name: S-adenosylmethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] +synonym: "S-adenosyl methionine biosynthesis" EXACT [] +synonym: "S-adenosyl methionine biosynthetic process" EXACT [] +synonym: "S-adenosylmethionine anabolism" EXACT [] +synonym: "S-adenosylmethionine biosynthesis" EXACT [] +synonym: "S-adenosylmethionine formation" EXACT [] +synonym: "S-adenosylmethionine synthesis" EXACT [] +synonym: "SAM biosynthetic process" EXACT [] +xref: MetaCyc:SAM-PWY +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046500 ! S-adenosylmethionine metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0006557 +name: S-adenosylmethioninamine biosynthetic process +namespace: biological_process +alt_id: GO:0006745 +def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] +synonym: "S-adenosylmethioninamine anabolism" EXACT [] +synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] +synonym: "S-adenosylmethioninamine formation" EXACT [] +synonym: "S-adenosylmethioninamine synthesis" EXACT [] +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process +is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process + +[Term] +id: GO:0006558 +name: L-phenylalanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah] +synonym: "L-phenylalanine metabolism" EXACT [] +synonym: "phenylalanine metabolic process" BROAD [] +synonym: "phenylalanine metabolism" BROAD [] +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process + +[Term] +id: GO:0006559 +name: L-phenylalanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] +synonym: "L-phenylalanine breakdown" EXACT [] +synonym: "L-phenylalanine catabolism" EXACT [] +synonym: "L-phenylalanine degradation" EXACT [] +synonym: "phenylalanine catabolic process" BROAD [] +synonym: "phenylalanine catabolism" BROAD [] +is_a: GO:0006558 ! L-phenylalanine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process +is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process + +[Term] +id: GO:0006560 +name: proline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "proline metabolism" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process + +[Term] +id: GO:0006561 +name: proline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] +synonym: "proline anabolism" EXACT [] +synonym: "proline biosynthesis" EXACT [] +synonym: "proline formation" EXACT [] +synonym: "proline synthesis" EXACT [] +xref: MetaCyc:PROSYN-PWY +xref: MetaCyc:PWY-3341 +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0009084 ! glutamine family amino acid biosynthetic process + +[Term] +id: GO:0006562 +name: proline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "proline breakdown" EXACT [] +synonym: "proline catabolism" EXACT [] +synonym: "proline degradation" EXACT [] +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009065 ! glutamine family amino acid catabolic process + +[Term] +id: GO:0006563 +name: L-serine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] +synonym: "L-serine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0006564 +name: L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] +synonym: "L-serine anabolism" EXACT [] +synonym: "L-serine biosynthesis" EXACT [] +synonym: "L-serine formation" EXACT [] +synonym: "L-serine synthesis" EXACT [] +xref: MetaCyc:SERSYN-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0006565 +name: L-serine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg] +synonym: "L-serine breakdown" EXACT [] +synonym: "L-serine catabolism" EXACT [] +synonym: "L-serine degradation" EXACT [] +xref: MetaCyc:SERDEG-PWY +is_a: GO:0006563 ! L-serine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0006566 +name: threonine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "methionine and threonine metabolic process" BROAD [] +synonym: "methionine and threonine metabolism" BROAD [] +synonym: "threonine metabolism" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0006567 +name: threonine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "threonine breakdown" EXACT [] +synonym: "threonine catabolism" EXACT [] +synonym: "threonine degradation" EXACT [] +xref: MetaCyc:THREOCAT-PWY +xref: UM-BBD_pathwayID:met +is_a: GO:0006566 ! threonine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0006568 +name: tryptophan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] +synonym: "tryptophan metabolism" EXACT [] +xref: Wikipedia:Tryptophan +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006569 +name: tryptophan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] +synonym: "tryptophan breakdown" EXACT [] +synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] +synonym: "tryptophan catabolism" EXACT [] +synonym: "tryptophan catabolism, using tryptophanase" NARROW [] +synonym: "tryptophan degradation" EXACT [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process +is_a: GO:0046218 ! indolalkylamine catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006570 +name: tyrosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] +synonym: "tyrosine metabolism" EXACT [] +xref: UM-BBD_pathwayID:tyr +xref: Wikipedia:Tyrosine +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006571 +name: tyrosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] +synonym: "tyrosine anabolism" EXACT [] +synonym: "tyrosine biosynthesis" EXACT [] +synonym: "tyrosine formation" EXACT [] +synonym: "tyrosine synthesis" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0006572 +name: tyrosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] +synonym: "tyrosine breakdown" EXACT [] +synonym: "tyrosine catabolism" EXACT [] +synonym: "tyrosine degradation" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0009074 ! aromatic amino acid family catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006573 +name: valine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +synonym: "valine metabolism" EXACT [] +is_a: GO:0009081 ! branched-chain amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006574 +name: valine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +synonym: "valine breakdown" EXACT [] +synonym: "valine catabolism" EXACT [] +synonym: "valine degradation" EXACT [] +xref: MetaCyc:VALDEG-PWY +is_a: GO:0006573 ! valine metabolic process +is_a: GO:0009083 ! branched-chain amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006575 +name: cellular modified amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +subset: goslim_drosophila +subset: goslim_generic +synonym: "amino acid derivative metabolic process" EXACT [] +synonym: "cellular amino acid derivative metabolic process" EXACT [] +synonym: "cellular amino acid derivative metabolism" EXACT [] +synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] +synonym: "modified amino acid metabolic process" EXACT [GOC:mah] +synonym: "modified amino acid metabolism" EXACT [GOC:mah] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006576 +name: cellular biogenic amine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] +synonym: "biogenic amine metabolism" EXACT [] +is_a: GO:0044106 ! cellular amine metabolic process + +[Term] +id: GO:0006577 +name: amino-acid betaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] +synonym: "betaine metabolic process" EXACT [] +synonym: "betaine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0006578 +name: amino-acid betaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] +synonym: "betaine anabolism" EXACT [] +synonym: "betaine biosynthesis" EXACT [] +synonym: "betaine biosynthetic process" EXACT [] +synonym: "betaine formation" EXACT [] +synonym: "betaine synthesis" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process + +[Term] +id: GO:0006579 +name: amino-acid betaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] +synonym: "betaine breakdown" EXACT [] +synonym: "betaine catabolic process" EXACT [] +synonym: "betaine catabolism" EXACT [] +synonym: "betaine degradation" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process + +[Term] +id: GO:0006580 +name: ethanolamine metabolic process +namespace: biological_process +alt_id: GO:0006645 +def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [ISBN:0192800981] +synonym: "ethanolamine metabolism" EXACT [] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042439 ! ethanolamine-containing compound metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0006581 +name: acetylcholine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] +synonym: "acetylcholine breakdown" EXACT [] +synonym: "acetylcholine catabolism" EXACT [] +synonym: "acetylcholine degradation" EXACT [] +is_a: GO:0008291 ! acetylcholine metabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0006582 +name: melanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] +synonym: "melanin metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0006583 +name: melanin biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] +synonym: "melanin anabolism from tyrosine" EXACT [] +synonym: "melanin formation from tyrosine" EXACT [] +synonym: "melanin synthesis from tyrosine" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0006584 +name: catecholamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] +synonym: "catecholamine metabolism" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0009712 ! catechol-containing compound metabolic process + +[Term] +id: GO:0006585 +name: dopamine biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732] +synonym: "dopamine anabolism from tyrosine" EXACT [] +synonym: "dopamine formation from tyrosine" EXACT [] +synonym: "dopamine synthesis from tyrosine" EXACT [] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0042416 ! dopamine biosynthetic process + +[Term] +id: GO:0006586 +name: indolalkylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] +synonym: "indolalkylamine metabolism" EXACT [] +synonym: "indolamine metabolic process" BROAD [] +synonym: "indolamine metabolism" BROAD [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:0006587 +name: serotonin biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] +synonym: "serotonin anabolism from tryptophan" EXACT [] +synonym: "serotonin formation from tryptophan" EXACT [] +synonym: "serotonin synthesis from tryptophan" EXACT [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0042427 ! serotonin biosynthetic process + +[Term] +id: GO:0006588 +name: activation of tryptophan 5-monooxygenase activity +namespace: biological_process +def: "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] +synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan + +[Term] +id: GO:0006589 +name: octopamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] +synonym: "octopamine anabolism" EXACT [] +synonym: "octopamine biosynthesis" EXACT [] +synonym: "octopamine formation" EXACT [] +synonym: "octopamine synthesis" EXACT [] +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0046333 ! octopamine metabolic process + +[Term] +id: GO:0006590 +name: thyroid hormone generation +namespace: biological_process +def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] +comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. +is_a: GO:0042403 ! thyroid hormone metabolic process + +[Term] +id: GO:0006591 +name: ornithine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +synonym: "ornithine metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006592 +name: ornithine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +synonym: "ornithine anabolism" EXACT [] +synonym: "ornithine biosynthesis" EXACT [] +synonym: "ornithine formation" EXACT [] +synonym: "ornithine synthesis" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0006593 +name: ornithine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] +synonym: "ornithine breakdown" EXACT [] +synonym: "ornithine catabolism" EXACT [] +synonym: "ornithine degradation" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0006595 +name: polyamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] +subset: goslim_drosophila +synonym: "polyamine metabolism" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process + +[Term] +id: GO:0006596 +name: polyamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] +synonym: "polyamine anabolism" EXACT [] +synonym: "polyamine biosynthesis" EXACT [] +synonym: "polyamine formation" EXACT [] +synonym: "polyamine synthesis" EXACT [] +xref: MetaCyc:POLYAMSYN-PWY +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process + +[Term] +id: GO:0006597 +name: spermine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [GOC:curators] +synonym: "spermine anabolism" EXACT [] +synonym: "spermine biosynthesis" EXACT [] +synonym: "spermine formation" EXACT [] +synonym: "spermine synthesis" EXACT [] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0006598 +name: polyamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] +synonym: "polyamine breakdown" EXACT [] +synonym: "polyamine catabolism" EXACT [] +synonym: "polyamine degradation" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process + +[Term] +id: GO:0006599 +name: phosphagen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] +synonym: "phosphagen metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process + +[Term] +id: GO:0006600 +name: creatine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] +synonym: "creatine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0006601 +name: creatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] +synonym: "creatine anabolism" EXACT [] +synonym: "creatine biosynthesis" EXACT [] +synonym: "creatine formation" EXACT [] +synonym: "creatine synthesis" EXACT [] +is_a: GO:0006600 ! creatine metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0006602 +name: creatinine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732] +synonym: "creatinine breakdown" EXACT [] +synonym: "creatinine catabolism" EXACT [] +synonym: "creatinine degradation" EXACT [] +is_a: GO:0046449 ! creatinine metabolic process +is_a: GO:0072340 ! cellular lactam catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0006603 +name: phosphocreatine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [PMID:16371597] +synonym: "phosphocreatine metabolism" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process + +[Term] +id: GO:0006604 +name: phosphoarginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597] +synonym: "phosphoarginine metabolism" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0006605 +name: protein targeting +namespace: biological_process +def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] +comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. +subset: goslim_chembl +subset: goslim_pombe +subset: goslim_yeast +synonym: "nascent polypeptide association" RELATED [] +synonym: "protein sorting along secretory pathway" NARROW [] +xref: Wikipedia:Protein_targeting +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0006606 +name: protein import into nucleus +namespace: biological_process +def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] +synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] +synonym: "protein import into cell nucleus" EXACT [] +synonym: "protein nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0017038 ! protein import +is_a: GO:0034504 ! protein localization to nucleus +is_a: GO:0051170 ! import into nucleus +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0006607 +name: NLS-bearing protein import into nucleus +namespace: biological_process +def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai] +synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] +synonym: "NLS-bearing substrate import into nucleus" EXACT [GOC:bf, GOC:jl] +synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] +synonym: "NLS-bearing substrate-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006608 +name: obsolete snRNP protein import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "snRNP protein import into cell nucleus" EXACT [] +synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] +synonym: "snRNP protein-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0006609 +name: obsolete mRNA-binding (hnRNP) protein import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] +synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] +synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0006610 +name: ribosomal protein import into nucleus +namespace: biological_process +def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus." [GOC:ai, PMID:11809816] +comment: Ribosomal protein rpl12 uses a different import pathway, which is why it has a separate GO term. +synonym: "ribosomal protein import into cell nucleus" EXACT [] +synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] +synonym: "ribosomal protein-nucleus import" EXACT [] +is_a: GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0006611 +name: protein export from nucleus +namespace: biological_process +alt_id: GO:0097349 +def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] +synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] +synonym: "protein export from cell nucleus" EXACT [] +synonym: "protein export out of nucleus" EXACT [] +synonym: "protein transport from nucleus to cytoplasm" EXACT [] +synonym: "protein-nucleus export" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0051168 ! nuclear export + +[Term] +id: GO:0006612 +name: protein targeting to membrane +namespace: biological_process +def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators] +synonym: "protein membrane targeting" EXACT [] +synonym: "protein-membrane targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0090150 ! establishment of protein localization to membrane + +[Term] +id: GO:0006613 +name: cotranslational protein targeting to membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] +synonym: "cotranslational membrane targeting" EXACT [] +synonym: "cotranslational protein membrane targeting" EXACT [] +synonym: "cotranslational protein-membrane targeting" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane + +[Term] +id: GO:0006614 +name: SRP-dependent cotranslational protein targeting to membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] +synonym: "ER translocation" BROAD [] +synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] +is_a: GO:0006613 ! cotranslational protein targeting to membrane +is_a: GO:0045047 ! protein targeting to ER + +[Term] +id: GO:0006615 +name: SRP-dependent cotranslational protein targeting to membrane, docking +namespace: biological_process +def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] +is_a: GO:0022615 ! protein to membrane docking +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006616 +name: SRP-dependent cotranslational protein targeting to membrane, translocation +namespace: biological_process +def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] +synonym: "ER translocation" BROAD [] +synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] +synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006617 +name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition +namespace: biological_process +def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006618 +name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing +namespace: biological_process +def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] +synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] +synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] +synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] +is_a: GO:0006465 ! signal peptide processing +relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane + +[Term] +id: GO:0006619 +name: obsolete SRP-independent cotranslational protein-membrane targeting +namespace: biological_process +def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] +comment: This term was made obsolete because there is no evidence for the existence of this process. +synonym: "ER translocation" BROAD [] +synonym: "SRP-independent cotranslational membrane targeting" EXACT [] +synonym: "SRP-independent cotranslational protein-membrane targeting" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006620 +name: posttranslational protein targeting to endoplasmic reticulum membrane +namespace: biological_process +def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] +synonym: "posttranslational endoplasmic reticulum membrane targeting" EXACT [] +synonym: "posttranslational endoplasmic reticulum protein-membrane targeting" EXACT [] +synonym: "posttranslational protein endoplasmic reticulum membrane targeting" EXACT [] +synonym: "posttranslational protein targeting to ER membrane" EXACT [] +synonym: "SRP-independent endoplasmic reticulum protein-membrane targeting" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane +is_a: GO:0045047 ! protein targeting to ER + +[Term] +id: GO:0006621 +name: protein retention in ER lumen +namespace: biological_process +def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] +synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] +is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum + +[Term] +id: GO:0006622 +name: protein targeting to lysosome +namespace: biological_process +def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators] +synonym: "protein-lysosome targeting" EXACT [] +is_a: GO:0006623 ! protein targeting to vacuole +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0061462 ! protein localization to lysosome + +[Term] +id: GO:0006623 +name: protein targeting to vacuole +namespace: biological_process +def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators] +synonym: "protein vacuolar targeting" EXACT [] +synonym: "protein-vacuolar targeting" EXACT [] +synonym: "protein-vacuole targeting" EXACT [] +synonym: "vacuolar protein sorting" EXACT [GOC:vw] +is_a: GO:0006605 ! protein targeting +is_a: GO:0007034 ! vacuolar transport +is_a: GO:0072666 ! establishment of protein localization to vacuole + +[Term] +id: GO:0006624 +name: vacuolar protein processing +namespace: biological_process +def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah] +synonym: "vacuolar protein maturation" RELATED [] +synonym: "vacuolar proteolysis" RELATED [] +is_a: GO:0016485 ! protein processing +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0006625 +name: protein targeting to peroxisome +namespace: biological_process +def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] +synonym: "protein-peroxisome targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0043574 ! peroxisomal transport +is_a: GO:0072663 ! establishment of protein localization to peroxisome + +[Term] +id: GO:0006626 +name: protein targeting to mitochondrion +namespace: biological_process +alt_id: GO:0043681 +def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] +synonym: "mitochondrial protein import" RELATED [] +synonym: "mitochondrial translocation" RELATED [] +synonym: "protein import into mitochondrion" EXACT [] +synonym: "protein targeting to mitochondria" EXACT [] +synonym: "protein-mitochondrial targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0072655 ! establishment of protein localization to mitochondrion +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0006627 +name: protein processing involved in protein targeting to mitochondrion +namespace: biological_process +def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] +synonym: "mitochondrial processing" BROAD [] +synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb] +is_a: GO:0034982 ! mitochondrial protein processing +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0006628 +name: obsolete mitochondrial translocation +namespace: biological_process +def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] +comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. +synonym: "mitochondrial translocation" EXACT [] +is_obsolete: true +consider: GO:0006626 + +[Term] +id: GO:0006629 +name: lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_pombe +subset: goslim_yeast +synonym: "lipid metabolism" EXACT [] +xref: Wikipedia:Lipid_metabolism +is_a: GO:0044238 ! primary metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0006630 +name: obsolete lipid binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "lipid binding" EXACT [] +is_obsolete: true +consider: GO:0008289 + +[Term] +id: GO:0006631 +name: fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] +synonym: "fatty acid metabolism" EXACT [] +xref: Wikipedia:Fatty_acid_metabolism +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006633 +name: fatty acid biosynthetic process +namespace: biological_process +alt_id: GO:0000037 +def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] +synonym: "fatty acid anabolism" EXACT [] +synonym: "fatty acid biosynthesis" EXACT [] +synonym: "fatty acid formation" EXACT [] +synonym: "fatty acid synthesis" EXACT [] +xref: MetaCyc:FASYN-INITIAL-PWY +xref: MetaCyc:PWY-4381 +xref: MetaCyc:PWY-5156 +xref: Wikipedia:Fatty_acid_synthesis +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0006634 +name: hexadecanal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] +synonym: "hexadecanal anabolism" EXACT [] +synonym: "hexadecanal biosynthesis" EXACT [] +synonym: "hexadecanal formation" EXACT [] +synonym: "hexadecanal synthesis" EXACT [] +synonym: "palmitaldehyde biosynthesis" EXACT [] +synonym: "palmitaldehyde biosynthetic process" EXACT [] +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0046458 ! hexadecanal metabolic process + +[Term] +id: GO:0006635 +name: fatty acid beta-oxidation +namespace: biological_process +def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0006636 +name: unsaturated fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] +synonym: "fatty acid desaturation" RELATED [] +synonym: "polyunsaturated fatty acid biosynthesis" NARROW [GOC:yaf, MetaCyc:PWY-762] +synonym: "unsaturated fatty acid anabolism" EXACT [] +synonym: "unsaturated fatty acid biosynthesis" EXACT [] +synonym: "unsaturated fatty acid formation" EXACT [] +synonym: "unsaturated fatty acid synthesis" EXACT [] +xref: MetaCyc:PWY-762 +xref: MetaCyc:PWY-782 +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process + +[Term] +id: GO:0006637 +name: acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] +synonym: "acyl-CoA metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process +is_a: GO:0035383 ! thioester metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0006638 +name: neutral lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] +synonym: "neutral lipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006639 +name: acylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732] +synonym: "acylglycerol metabolism" EXACT [] +synonym: "glyceride metabolic process" EXACT [] +synonym: "glyceride metabolism" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0006640 +name: monoacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732] +synonym: "monoacylglycerol anabolism" EXACT [] +synonym: "monoacylglycerol biosynthesis" EXACT [] +synonym: "monoacylglycerol formation" EXACT [] +synonym: "monoacylglycerol synthesis" EXACT [] +synonym: "monoglyceride biosynthesis" EXACT [] +synonym: "monoglyceride biosynthetic process" EXACT [] +is_a: GO:0046462 ! monoacylglycerol metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0006641 +name: triglyceride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732] +synonym: "triacylglycerol metabolic process" EXACT [] +synonym: "triacylglycerol metabolism" EXACT [] +synonym: "triglyceride metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0006642 +name: triglyceride mobilization +namespace: biological_process +def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] +synonym: "triacylglycerol mobilization" EXACT [] +is_a: GO:0006641 ! triglyceride metabolic process + +[Term] +id: GO:0006643 +name: membrane lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +synonym: "membrane lipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006644 +name: phospholipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] +synonym: "phospholipid metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006646 +name: phosphatidylethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] +synonym: "phosphatidylethanolamine anabolism" EXACT [] +synonym: "phosphatidylethanolamine biosynthesis" EXACT [] +synonym: "phosphatidylethanolamine formation" EXACT [] +synonym: "phosphatidylethanolamine synthesis" EXACT [] +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006647 +name: phosphatidyl-N-monomethylethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] +synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] +synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] +synonym: "PMME biosynthesis" EXACT [] +synonym: "PMME biosynthetic process" EXACT [] +is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process +is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process + +[Term] +id: GO:0006648 +name: dihydrosphingosine-1-P pathway +namespace: biological_process +def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073] +is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process + +[Term] +id: GO:0006649 +name: phospholipid transfer to membrane +namespace: biological_process +def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] +is_a: GO:0015914 ! phospholipid transport +relationship: part_of GO:0061024 ! membrane organization + +[Term] +id: GO:0006650 +name: glycerophospholipid metabolic process +namespace: biological_process +alt_id: GO:0006652 +def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] +synonym: "alpha-glycerophosphate pathway" RELATED [] +synonym: "glycerophospholipid metabolism" EXACT [] +synonym: "phosphoglyceride metabolic process" EXACT [] +synonym: "phosphoglyceride metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0006651 +name: diacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [GOC:curators] +synonym: "diacylglycerol anabolism" EXACT [] +synonym: "diacylglycerol biosynthesis" EXACT [] +synonym: "diacylglycerol formation" EXACT [] +synonym: "diacylglycerol synthesis" EXACT [] +synonym: "diglyceride biosynthesis" EXACT [] +is_a: GO:0046339 ! diacylglycerol metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0006653 +name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [ISBN:0198506732] +synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah] +synonym: "lecithin metabolic process" BROAD [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0006654 +name: phosphatidic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732] +synonym: "phosphatidic acid anabolism" EXACT [] +synonym: "phosphatidic acid biosynthesis" EXACT [] +synonym: "phosphatidic acid formation" EXACT [] +synonym: "phosphatidic acid synthesis" EXACT [] +is_a: GO:0046473 ! phosphatidic acid metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006655 +name: phosphatidylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732] +synonym: "phosphatidylglycerol anabolism" EXACT [] +synonym: "phosphatidylglycerol biosynthesis" EXACT [] +synonym: "phosphatidylglycerol formation" EXACT [] +synonym: "phosphatidylglycerol synthesis" EXACT [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006656 +name: phosphatidylcholine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732] +synonym: "phosphatidylcholine anabolism" EXACT [] +synonym: "phosphatidylcholine biosynthesis" EXACT [] +synonym: "phosphatidylcholine formation" EXACT [] +synonym: "phosphatidylcholine synthesis" EXACT [] +is_a: GO:0046470 ! phosphatidylcholine metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0006657 +name: CDP-choline pathway +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450] +synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450] +synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450] +xref: MetaCyc:PWY3O-450 +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0006658 +name: phosphatidylserine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732] +synonym: "phosphatidylserine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0006659 +name: phosphatidylserine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] +synonym: "phosphatidylserine anabolism" EXACT [] +synonym: "phosphatidylserine biosynthesis" EXACT [] +synonym: "phosphatidylserine formation" EXACT [] +synonym: "phosphatidylserine synthesis" EXACT [] +is_a: GO:0006658 ! phosphatidylserine metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0006660 +name: phosphatidylserine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] +synonym: "phosphatidylserine breakdown" EXACT [] +synonym: "phosphatidylserine catabolism" EXACT [] +synonym: "phosphatidylserine degradation" EXACT [] +is_a: GO:0006658 ! phosphatidylserine metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0006661 +name: phosphatidylinositol biosynthetic process +namespace: biological_process +alt_id: GO:0046489 +def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] +synonym: "phosphatidylinositol anabolism" EXACT [] +synonym: "phosphatidylinositol biosynthesis" EXACT [] +synonym: "phosphatidylinositol formation" EXACT [] +synonym: "phosphatidylinositol synthesis" EXACT [] +synonym: "phosphoinositide biosynthesis" EXACT [] +synonym: "phosphoinositide biosynthetic process" EXACT [] +synonym: "PtdIns biosynthesis" EXACT [] +synonym: "PtdIns biosynthetic process" EXACT [] +is_a: GO:0046474 ! glycerophospholipid biosynthetic process +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:0006662 +name: glycerol ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732] +subset: goslim_pir +synonym: "glycerol ether metabolism" EXACT [] +is_a: GO:0018904 ! ether metabolic process + +[Term] +id: GO:0006663 +name: platelet activating factor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] +synonym: "PAF biosynthesis" EXACT [] +synonym: "PAF biosynthetic process" EXACT [] +synonym: "platelet activating factor anabolism" EXACT [] +synonym: "platelet activating factor biosynthesis" EXACT [] +synonym: "platelet activating factor formation" EXACT [] +synonym: "platelet activating factor synthesis" EXACT [] +is_a: GO:0008611 ! ether lipid biosynthetic process +is_a: GO:0046469 ! platelet activating factor metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0006664 +name: glycolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [ISBN:0198547684] +synonym: "glycolipid metabolism" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:1903509 ! liposaccharide metabolic process + +[Term] +id: GO:0006665 +name: sphingolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] +synonym: "sphingolipid metabolism" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006666 +name: 3-keto-sphinganine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] +synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] +synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] +synonym: "3-keto-sphinganine metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006667 +name: sphinganine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [PMID:29165427] +synonym: "dihydrosphingosine metabolic process" EXACT [] +synonym: "dihydrosphingosine metabolism" EXACT [] +synonym: "sphinganine metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006668 +name: sphinganine-1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] +synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] +synonym: "sphinganine-1-phosphate metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0006669 +name: sphinganine-1-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] +synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] +synonym: "sphinganine-1-phosphate anabolism" EXACT [] +synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] +synonym: "sphinganine-1-phosphate formation" EXACT [] +synonym: "sphinganine-1-phosphate synthesis" EXACT [] +is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0006670 +name: sphingosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732] +synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] +synonym: "(4E)-sphing-4-enine metabolism" EXACT [] +synonym: "sphing-4-enine metabolic process" EXACT [] +synonym: "sphing-4-enine metabolism" EXACT [] +synonym: "sphingosine metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006671 +name: phytosphingosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [ISBN:0198506732] +synonym: "phytosphingosine metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0006672 +name: ceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] +synonym: "ceramide metabolism" EXACT [] +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0006673 +name: inositol phosphoceramide metabolic process +namespace: biological_process +alt_id: GO:0006674 +def: "The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [PMID:19726565] +synonym: "inositol phosphorylceramide metabolic process" EXACT [] +synonym: "inositol phosphorylceramide metabolism" EXACT [] +synonym: "inositolphosphoceramide metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0006675 +name: mannosyl-inositol phosphorylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] +synonym: "mannose inositol phosphoceramide metabolic process" EXACT [] +synonym: "mannose inositol phosphoceramide metabolism" EXACT [] +synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] +synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] +synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] +synonym: "MIPC metabolic process" EXACT [] +synonym: "MIPC metabolism" EXACT [] +is_a: GO:0006673 ! inositol phosphoceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0006676 +name: mannosyl diphosphorylinositol ceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] +synonym: "M(IP)2C metabolic process" EXACT [] +synonym: "M(IP)2C metabolism" EXACT [] +synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] +is_a: GO:0006505 ! GPI anchor metabolic process +is_a: GO:0006673 ! inositol phosphoceramide metabolic process + +[Term] +id: GO:0006677 +name: glycosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732] +synonym: "glycosylceramide metabolism" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0006678 +name: glucosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [ISBN:0198506732] +synonym: "glucosylceramide metabolism" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process + +[Term] +id: GO:0006679 +name: glucosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] +synonym: "glucosylceramide anabolism" EXACT [] +synonym: "glucosylceramide biosynthesis" EXACT [] +synonym: "glucosylceramide formation" EXACT [] +synonym: "glucosylceramide synthesis" EXACT [] +is_a: GO:0006678 ! glucosylceramide metabolic process +is_a: GO:0046476 ! glycosylceramide biosynthetic process + +[Term] +id: GO:0006680 +name: glucosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] +synonym: "glucosylceramide breakdown" EXACT [] +synonym: "glucosylceramide catabolism" EXACT [] +synonym: "glucosylceramide degradation" EXACT [] +is_a: GO:0006678 ! glucosylceramide metabolic process +is_a: GO:0046477 ! glycosylceramide catabolic process + +[Term] +id: GO:0006681 +name: galactosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +synonym: "galactosylceramide metabolism" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0019374 ! galactolipid metabolic process + +[Term] +id: GO:0006682 +name: galactosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +synonym: "galactosylceramide anabolism" EXACT [] +synonym: "galactosylceramide biosynthesis" EXACT [] +synonym: "galactosylceramide formation" EXACT [] +synonym: "galactosylceramide synthesis" EXACT [] +is_a: GO:0006681 ! galactosylceramide metabolic process +is_a: GO:0019375 ! galactolipid biosynthetic process +is_a: GO:0046476 ! glycosylceramide biosynthetic process + +[Term] +id: GO:0006683 +name: galactosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] +synonym: "galactosylceramide breakdown" EXACT [] +synonym: "galactosylceramide catabolism" EXACT [] +synonym: "galactosylceramide degradation" EXACT [] +is_a: GO:0006681 ! galactosylceramide metabolic process +is_a: GO:0019376 ! galactolipid catabolic process +is_a: GO:0046477 ! glycosylceramide catabolic process + +[Term] +id: GO:0006684 +name: sphingomyelin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732] +synonym: "sphingomyelin metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0006685 +name: sphingomyelin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] +synonym: "sphingomyelin breakdown" EXACT [] +synonym: "sphingomyelin catabolism" EXACT [] +synonym: "sphingomyelin degradation" EXACT [] +is_a: GO:0006684 ! sphingomyelin metabolic process +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0006686 +name: sphingomyelin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] +synonym: "sphingomyelin anabolism" EXACT [] +synonym: "sphingomyelin biosynthesis" EXACT [] +synonym: "sphingomyelin formation" EXACT [] +synonym: "sphingomyelin synthesis" EXACT [] +is_a: GO:0006684 ! sphingomyelin metabolic process +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0006687 +name: glycosphingolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] +synonym: "glycosphingolipid metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0006688 +name: glycosphingolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] +synonym: "glycosphingolipid anabolism" EXACT [] +synonym: "glycosphingolipid biosynthesis" EXACT [] +synonym: "glycosphingolipid formation" EXACT [] +synonym: "glycosphingolipid synthesis" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0006689 +name: ganglioside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] +synonym: "ganglioside breakdown" EXACT [] +synonym: "ganglioside catabolism" EXACT [] +synonym: "ganglioside degradation" EXACT [] +is_a: GO:0001573 ! ganglioside metabolic process +is_a: GO:0046479 ! glycosphingolipid catabolic process +is_a: GO:0046514 ! ceramide catabolic process + +[Term] +id: GO:0006690 +name: icosanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] +synonym: "eicosanoid metabolic process" EXACT [] +synonym: "eicosanoid metabolism" EXACT [] +synonym: "icosanoid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0006691 +name: leukotriene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] +synonym: "leukotriene metabolism" EXACT [] +is_a: GO:0006690 ! icosanoid metabolic process + +[Term] +id: GO:0006692 +name: prostanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732] +synonym: "prostanoid metabolism" EXACT [] +is_a: GO:0006690 ! icosanoid metabolic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process + +[Term] +id: GO:0006693 +name: prostaglandin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732] +synonym: "prostaglandin metabolism" EXACT [] +is_a: GO:0006692 ! prostanoid metabolic process + +[Term] +id: GO:0006694 +name: steroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] +synonym: "steroid anabolism" EXACT [] +synonym: "steroid biosynthesis" EXACT [] +synonym: "steroid formation" EXACT [] +synonym: "steroid synthesis" EXACT [] +synonym: "steroidogenesis" EXACT [] +xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0006695 +name: cholesterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] +synonym: "cholesterol anabolism" EXACT [] +synonym: "cholesterol biosynthesis" EXACT [] +synonym: "cholesterol formation" EXACT [] +synonym: "cholesterol synthesis" EXACT [] +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0016126 ! sterol biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0006696 +name: ergosterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732] +synonym: "ergosterol anabolism" EXACT [] +synonym: "ergosterol biosynthesis" EXACT [] +synonym: "ergosterol formation" EXACT [] +synonym: "ergosterol synthesis" EXACT [] +is_a: GO:0008204 ! ergosterol metabolic process +is_a: GO:0016126 ! sterol biosynthetic process +is_a: GO:0016129 ! phytosteroid biosynthetic process +is_a: GO:0044108 ! cellular alcohol biosynthetic process +is_a: GO:0097384 ! cellular lipid biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0006697 +name: ecdysone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] +synonym: "ecdysone anabolism" EXACT [] +synonym: "ecdysone biosynthesis" EXACT [] +synonym: "ecdysone formation" EXACT [] +synonym: "ecdysone synthesis" EXACT [] +is_a: GO:0008205 ! ecdysone metabolic process +is_a: GO:0016126 ! sterol biosynthetic process +is_a: GO:0045456 ! ecdysteroid biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0006698 +name: obsolete ecdysone modification +namespace: biological_process +def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] +comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC:1.14.99.22) and so is a function rather than a process. +synonym: "ecdysone modification" EXACT [] +is_obsolete: true +replaced_by: GO:0004501 + +[Term] +id: GO:0006699 +name: bile acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid anabolism" EXACT [] +synonym: "bile acid biosynthesis" EXACT [] +synonym: "bile acid formation" EXACT [] +synonym: "bile acid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0006700 +name: C21-steroid hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone anabolism" EXACT [] +synonym: "C21-steroid hormone biosynthesis" EXACT [] +synonym: "C21-steroid hormone formation" EXACT [] +synonym: "C21-steroid hormone synthesis" EXACT [] +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0006701 +name: progesterone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone anabolism" EXACT [] +synonym: "progesterone biosynthesis" EXACT [] +synonym: "progesterone formation" EXACT [] +synonym: "progesterone synthesis" EXACT [] +is_a: GO:0006700 ! C21-steroid hormone biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0042448 ! progesterone metabolic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:0006702 +name: androgen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] +synonym: "androgen anabolism" EXACT [] +synonym: "androgen biosynthesis" EXACT [] +synonym: "androgen formation" EXACT [] +synonym: "androgen synthesis" EXACT [] +is_a: GO:0008209 ! androgen metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0006703 +name: estrogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] +synonym: "estrogen anabolism" EXACT [] +synonym: "estrogen biosynthesis" EXACT [] +synonym: "estrogen formation" EXACT [] +synonym: "estrogen synthesis" EXACT [] +synonym: "oestrogen biosynthesis" EXACT [] +synonym: "oestrogen biosynthetic process" EXACT [] +is_a: GO:0008210 ! estrogen metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0006704 +name: glucocorticoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] +synonym: "glucocorticoid anabolism" EXACT [] +synonym: "glucocorticoid biosynthesis" EXACT [] +synonym: "glucocorticoid formation" EXACT [] +synonym: "glucocorticoid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0006705 +name: mineralocorticoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] +synonym: "mineralocorticoid anabolism" EXACT [] +synonym: "mineralocorticoid biosynthesis" EXACT [] +synonym: "mineralocorticoid formation" EXACT [] +synonym: "mineralocorticoid synthesis" EXACT [] +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0006706 +name: steroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] +synonym: "steroid breakdown" EXACT [] +synonym: "steroid catabolism" EXACT [] +synonym: "steroid degradation" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0006707 +name: cholesterol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] +synonym: "cholesterol breakdown" EXACT [] +synonym: "cholesterol catabolism" EXACT [] +synonym: "cholesterol degradation" EXACT [] +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0016127 ! sterol catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0006708 +name: ecdysone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] +synonym: "ecdysone breakdown" EXACT [] +synonym: "ecdysone catabolism" EXACT [] +synonym: "ecdysone degradation" EXACT [] +is_a: GO:0008205 ! ecdysone metabolic process +is_a: GO:0016127 ! sterol catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046344 ! ecdysteroid catabolic process + +[Term] +id: GO:0006709 +name: progesterone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone breakdown" EXACT [] +synonym: "progesterone catabolism" EXACT [] +synonym: "progesterone degradation" EXACT [] +is_a: GO:0008208 ! C21-steroid hormone catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0042448 ! progesterone metabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0006710 +name: androgen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] +synonym: "androgen breakdown" EXACT [] +synonym: "androgen catabolism" EXACT [] +synonym: "androgen degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008209 ! androgen metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006711 +name: estrogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] +synonym: "estrogen breakdown" EXACT [] +synonym: "estrogen catabolism" EXACT [] +synonym: "estrogen degradation" EXACT [] +synonym: "oestrogen catabolic process" EXACT [] +synonym: "oestrogen catabolism" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008210 ! estrogen metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006712 +name: mineralocorticoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] +synonym: "mineralocorticoid breakdown" EXACT [] +synonym: "mineralocorticoid catabolism" EXACT [] +synonym: "mineralocorticoid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006713 +name: glucocorticoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] +synonym: "glucocorticoid breakdown" EXACT [] +synonym: "glucocorticoid catabolism" EXACT [] +synonym: "glucocorticoid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0006714 +name: sesquiterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] +synonym: "sesquiterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0006715 +name: farnesol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] +synonym: "farnesol anabolism" EXACT [] +synonym: "farnesol biosynthesis" EXACT [] +synonym: "farnesol formation" EXACT [] +synonym: "farnesol synthesis" EXACT [] +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0016487 ! farnesol metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process + +[Term] +id: GO:0006716 +name: juvenile hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone metabolism" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0006717 +name: obsolete juvenile hormone binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "juvenile hormone binding" EXACT [] +is_obsolete: true +consider: GO:0005500 + +[Term] +id: GO:0006718 +name: juvenile hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone anabolism" EXACT [] +synonym: "juvenile hormone biosynthesis" EXACT [] +synonym: "juvenile hormone formation" EXACT [] +synonym: "juvenile hormone synthesis" EXACT [] +is_a: GO:0006716 ! juvenile hormone metabolic process +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0006719 +name: juvenile hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +synonym: "juvenile hormone breakdown" EXACT [] +synonym: "juvenile hormone catabolism" EXACT [] +synonym: "juvenile hormone degradation" EXACT [] +is_a: GO:0006716 ! juvenile hormone metabolic process +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0006720 +name: isoprenoid metabolic process +namespace: biological_process +alt_id: GO:0016096 +def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] +synonym: "isoprenoid metabolism" EXACT [] +synonym: "polyisoprenoid metabolic process" NARROW [] +synonym: "polyisoprenoid metabolism" NARROW [] +synonym: "polyterpene metabolic process" NARROW [] +synonym: "polyterpene metabolism" NARROW [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0006721 +name: terpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] +synonym: "terpenoid metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0006722 +name: triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] +synonym: "triterpene metabolic process" NARROW [] +synonym: "triterpene metabolism" NARROW [] +synonym: "triterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0006723 +name: cuticle hydrocarbon biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] +synonym: "cuticle hydrocarbon anabolism" EXACT [] +synonym: "cuticle hydrocarbon biosynthesis" EXACT [] +synonym: "cuticle hydrocarbon formation" EXACT [] +synonym: "cuticle hydrocarbon synthesis" EXACT [] +is_a: GO:0120251 ! hydrocarbon biosynthetic process +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0006725 +name: cellular aromatic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] +subset: goslim_pir +synonym: "aromatic compound metabolism" EXACT [] +synonym: "aromatic hydrocarbon metabolic process" NARROW [] +synonym: "aromatic hydrocarbon metabolism" NARROW [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006726 +name: eye pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment anabolism" EXACT [] +synonym: "eye pigment biosynthesis" EXACT [] +synonym: "eye pigment formation" EXACT [] +synonym: "eye pigment synthesis" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006727 +name: ommochrome biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] +synonym: "ommochrome anabolism" EXACT [] +synonym: "ommochrome biosynthesis" EXACT [] +synonym: "ommochrome formation" EXACT [] +synonym: "ommochrome synthesis" EXACT [] +is_a: GO:0006726 ! eye pigment biosynthetic process +is_a: GO:0008055 ! ocellus pigment biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0046152 ! ommochrome metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0006728 +name: pteridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] +synonym: "pteridine anabolism" EXACT [] +synonym: "pteridine biosynthesis" EXACT [] +synonym: "pteridine formation" EXACT [] +synonym: "pteridine synthesis" EXACT [] +synonym: "pterin biosynthesis" NARROW [] +synonym: "pterin biosynthetic process" NARROW [] +is_a: GO:0019889 ! pteridine metabolic process +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006729 +name: tetrahydrobiopterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732] +synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT [] +synonym: "tetrahydrobiopterin anabolism" EXACT [] +synonym: "tetrahydrobiopterin biosynthesis" EXACT [] +synonym: "tetrahydrobiopterin formation" EXACT [] +synonym: "tetrahydrobiopterin synthesis" EXACT [] +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process +is_a: GO:0046146 ! tetrahydrobiopterin metabolic process + +[Term] +id: GO:0006730 +name: one-carbon metabolic process +namespace: biological_process +alt_id: GO:0019753 +alt_id: GO:0019754 +def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] +subset: goslim_pir +synonym: "one carbon metabolic process" EXACT [GOC:mah] +synonym: "one carbon metabolism" EXACT [GOC:mah] +synonym: "one-carbon metabolism" EXACT [GOC:mah] +synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah] +synonym: "one-carbon transfer metabolism" EXACT [GOC:mah] +xref: UM-BBD_pathwayID:C1cyc +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0006731 +name: obsolete coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "coenzyme and prosthetic group metabolic process" EXACT [] +is_obsolete: true +consider: GO:0051189 + +[Term] +id: GO:0006732 +name: obsolete coenzyme metabolic process +namespace: biological_process +alt_id: GO:0006752 +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "coenzyme and prosthetic group metabolism" BROAD [] +synonym: "coenzyme metabolism" EXACT [] +synonym: "group transfer coenzyme metabolic process" NARROW [] +synonym: "group transfer coenzyme metabolism" NARROW [] +is_obsolete: true + +[Term] +id: GO:0006733 +name: obsolete oxidoreduction coenzyme metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "oxidoreduction coenzyme metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006734 +name: NADH metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +synonym: "NAD (reduced) metabolic process" EXACT [] +synonym: "NAD (reduced) metabolism" EXACT [] +synonym: "NADH metabolism" EXACT [] +synonym: "reduced NAD metabolic process" EXACT [] +synonym: "reduced NAD metabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0006735 +name: NADH regeneration +namespace: biological_process +def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah] +synonym: "NAD (reduced) regeneration" EXACT [] +synonym: "reduced NAD regeneration" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0006738 +name: nicotinamide riboside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] +synonym: "N-ribosylnicotinamide catabolic process" EXACT [] +synonym: "nicotinamide riboside breakdown" EXACT [] +synonym: "nicotinamide riboside catabolism" EXACT [] +synonym: "nicotinamide riboside degradation" EXACT [] +is_a: GO:0046495 ! nicotinamide riboside metabolic process +is_a: GO:0070638 ! pyridine nucleoside catabolic process + +[Term] +id: GO:0006739 +name: NADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +synonym: "NAD phosphorylation and dephosphorylation" RELATED [] +synonym: "NADP (oxidized) metabolic process" EXACT [] +synonym: "NADP (oxidized) metabolism" EXACT [] +synonym: "NADP (reduced) metabolic process" EXACT [] +synonym: "NADP (reduced) metabolism" EXACT [] +synonym: "NADP metabolism" EXACT [] +synonym: "NADPH metabolic process" EXACT [] +synonym: "NADPH metabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +synonym: "oxidized NADP metabolic process" EXACT [] +synonym: "oxidized NADP metabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +synonym: "reduced NADP metabolic process" EXACT [] +synonym: "reduced NADP metabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0006740 +name: NADPH regeneration +namespace: biological_process +def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah] +synonym: "NADP (reduced) regeneration" EXACT [] +synonym: "reduced NADP regeneration" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0006739 ! NADP metabolic process + +[Term] +id: GO:0006741 +name: NADP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +synonym: "NADP (oxidized) biosynthesis" EXACT [] +synonym: "NADP (oxidized) biosynthetic process" EXACT [] +synonym: "NADP (reduced) biosynthesis" EXACT [] +synonym: "NADP (reduced) biosynthetic process" EXACT [] +synonym: "NADP anabolism" EXACT [] +synonym: "NADP biosynthesis" EXACT [] +synonym: "NADP formation" EXACT [] +synonym: "NADP synthesis" EXACT [] +synonym: "NADPH biosynthesis" EXACT [] +synonym: "NADPH biosynthetic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +synonym: "oxidized NADP biosynthesis" EXACT [] +synonym: "oxidized NADP biosynthetic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +synonym: "reduced NADP biosynthesis" EXACT [] +synonym: "reduced NADP biosynthetic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] +is_a: GO:0006739 ! NADP metabolic process +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0006742 +name: NADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] +synonym: "NADP (oxidized) catabolic process" EXACT [] +synonym: "NADP (oxidized) catabolism" EXACT [] +synonym: "NADP (reduced) catabolic process" EXACT [] +synonym: "NADP (reduced) catabolism" EXACT [] +synonym: "NADP breakdown" EXACT [] +synonym: "NADP catabolism" EXACT [] +synonym: "NADP degradation" EXACT [] +synonym: "NADPH catabolic process" EXACT [] +synonym: "NADPH catabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +synonym: "oxidized NADP catabolic process" EXACT [] +synonym: "oxidized NADP catabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +synonym: "reduced NADP catabolic process" EXACT [] +synonym: "reduced NADP catabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] +is_a: GO:0006739 ! NADP metabolic process +is_a: GO:0019364 ! pyridine nucleotide catabolic process +is_a: GO:0046496 ! nicotinamide nucleotide metabolic process + +[Term] +id: GO:0006743 +name: ubiquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +synonym: "coenzyme Q metabolic process" EXACT [] +synonym: "coenzyme Q metabolism" EXACT [] +synonym: "ubiquinone metabolism" EXACT [] +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:0006744 +name: ubiquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +subset: goslim_drosophila +subset: goslim_pombe +synonym: "coenzyme Q biosynthesis" EXACT [] +synonym: "coenzyme Q biosynthetic process" EXACT [] +synonym: "coenzyme Q10 biosynthesis" NARROW [] +synonym: "coenzyme Q10 biosynthetic process" NARROW [] +synonym: "coenzyme Q6 biosynthesis" NARROW [] +synonym: "coenzyme Q6 biosynthetic process" NARROW [] +synonym: "coenzyme Q8 biosynthesis" NARROW [] +synonym: "coenzyme Q8 biosynthetic process" NARROW [] +synonym: "coenzyme Q9 biosynthesis" NARROW [] +synonym: "coenzyme Q9 biosynthetic process" NARROW [] +synonym: "ubiquinone anabolism" EXACT [] +synonym: "ubiquinone biosynthesis" EXACT [] +synonym: "ubiquinone formation" EXACT [] +synonym: "ubiquinone synthesis" EXACT [] +xref: MetaCyc:UBISYN-PWY +is_a: GO:0006743 ! ubiquinone metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0006746 +name: FADH2 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [GOC:ai] +synonym: "FADH2 metabolism" EXACT [] +synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah] +is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process + +[Term] +id: GO:0006747 +name: FAD biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:ai, PMID:20822113] +synonym: "FAD anabolism" EXACT [] +synonym: "FAD biosynthesis" EXACT [] +synonym: "FAD formation" EXACT [] +synonym: "FAD synthesis" EXACT [] +synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT [] +synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT [] +synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT [] +synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT [] +is_a: GO:0046443 ! FAD metabolic process +is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process + +[Term] +id: GO:0006748 +name: lipoamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] +synonym: "lipoamide metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006749 +name: glutathione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [ISBN:0198506732] +synonym: "glutathione metabolism" EXACT [] +synonym: "oxidized glutathione reduction" NARROW [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0006750 +name: glutathione biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] +synonym: "glutathione anabolism" EXACT [] +synonym: "glutathione biosynthesis" EXACT [] +synonym: "glutathione formation" EXACT [] +synonym: "glutathione synthesis" EXACT [] +xref: MetaCyc:GLUTATHIONESYN-PWY +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0019184 ! nonribosomal peptide biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0006751 +name: glutathione catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, ISBN:0198506732] +synonym: "glutathione breakdown" EXACT [] +synonym: "glutathione catabolism" EXACT [] +synonym: "glutathione degradation" EXACT [] +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0006753 +name: nucleoside phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] +synonym: "nucleoside phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process + +[Term] +id: GO:0006754 +name: ATP biosynthetic process +namespace: biological_process +alt_id: GO:0006758 +alt_id: GO:0006759 +def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] +synonym: "ATP anabolism" EXACT [] +synonym: "ATP biosynthesis" EXACT [] +synonym: "ATP formation" EXACT [] +synonym: "ATP regeneration" NARROW [] +synonym: "ATP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0006755 +name: obsolete carbamoyl phosphate-ADP transphosphorylation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). +synonym: "carbamoyl phosphate-ADP transphosphorylation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006756 +name: AMP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] +is_a: GO:0006754 ! ATP biosynthetic process +is_a: GO:0046033 ! AMP metabolic process +is_a: GO:0046940 ! nucleoside monophosphate phosphorylation + +[Term] +id: GO:0006757 +name: ATP generation from ADP +namespace: biological_process +def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] +synonym: "ADP phosphorylation" EXACT [GOC:dph] +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation +is_a: GO:0046031 ! ADP metabolic process +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0006760 +name: folic acid-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [GOC:ai, GOC:mah] +synonym: "folate and derivative metabolic process" EXACT [] +synonym: "folate and derivative metabolism" EXACT [] +synonym: "folate-containing compound metabolic process" EXACT [] +synonym: "folate-containing compound metabolism" EXACT [] +synonym: "folic acid and derivative metabolic process" EXACT [] +synonym: "folic acid and derivative metabolism" EXACT [] +synonym: "folic acid-containing compound metabolism" EXACT [] +synonym: "vitamin B9 and derivative metabolic process" EXACT [] +synonym: "vitamin B9 and derivative metabolism" EXACT [] +synonym: "vitamin M and derivative metabolic process" EXACT [] +synonym: "vitamin M and derivative metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:0006761 +name: dihydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] +synonym: "7,8-dihydrofolate biosynthesis" EXACT [] +synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] +synonym: "dihydrofolate anabolism" EXACT [] +synonym: "dihydrofolate biosynthesis" EXACT [] +synonym: "dihydrofolate formation" EXACT [] +synonym: "dihydrofolate synthesis" EXACT [] +is_a: GO:0009396 ! folic acid-containing compound biosynthetic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046452 ! dihydrofolate metabolic process + +[Term] +id: GO:0006762 +name: obsolete dihydrofolate reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "dihydrofolate reduction" EXACT [] +is_obsolete: true +consider: GO:0004146 +consider: GO:0046452 + +[Term] +id: GO:0006766 +name: vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +synonym: "vitamin metabolism" EXACT [] +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0006767 +name: water-soluble vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] +synonym: "water-soluble vitamin metabolism" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0006768 +name: biotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732] +synonym: "biotin metabolism" EXACT [] +synonym: "vitamin B7 metabolic process" EXACT [] +synonym: "vitamin B7 metabolism" EXACT [] +synonym: "vitamin H metabolic process" EXACT [] +synonym: "vitamin H metabolism" EXACT [] +xref: Wikipedia:Biotin +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0006769 +name: nicotinamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732] +synonym: "niacin metabolic process" RELATED [] +synonym: "niacin metabolism" RELATED [] +synonym: "nicotinamide metabolism" EXACT [] +synonym: "vitamin B3 metabolic process" BROAD [] +synonym: "vitamin B3 metabolism" BROAD [] +xref: MetaCyc:PWY-5083 +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0006771 +name: riboflavin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "riboflavin metabolism" EXACT [] +synonym: "vitamin B2 metabolic process" EXACT [] +synonym: "vitamin B2 metabolism" EXACT [] +synonym: "vitamin G metabolic process" EXACT [] +synonym: "vitamin G metabolism" EXACT [] +xref: Wikipedia:Riboflavin +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0042726 ! flavin-containing compound metabolic process + +[Term] +id: GO:0006772 +name: thiamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] +synonym: "thiamin metabolic process" EXACT [] +synonym: "thiamin metabolism" EXACT [] +synonym: "thiamine metabolism" EXACT [] +synonym: "vitamin B1 metabolic process" EXACT [] +synonym: "vitamin B1 metabolism" EXACT [] +xref: Wikipedia:Thiamine +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042723 ! thiamine-containing compound metabolic process + +[Term] +id: GO:0006774 +name: obsolete vitamin B12 reduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "vitamin B12 reduction" EXACT [] +is_obsolete: true +consider: GO:0009235 +consider: GO:0050453 + +[Term] +id: GO:0006775 +name: fat-soluble vitamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] +synonym: "fat-soluble vitamin metabolism" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0006776 +name: vitamin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "vitamin A metabolism" EXACT [] +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0006775 ! fat-soluble vitamin metabolic process + +[Term] +id: GO:0006777 +name: Mo-molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] +synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] +synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] +synonym: "Mo-molybdopterin cofactor formation" EXACT [] +synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] +synonym: "Moco biosynthesis" EXACT [] +synonym: "Moco biosynthetic process" EXACT [] +synonym: "molybdenum cofactor biosynthetic process" RELATED [] +xref: MetaCyc:PWY-6823 +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0006778 +name: porphyrin-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation] +synonym: "porphyrin metabolic process" RELATED [] +synonym: "porphyrin metabolism" RELATED [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0006779 +name: porphyrin-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732, Wikipedia:Porphyrin#Natural_formation] +synonym: "porphyrin anabolism" RELATED [] +synonym: "porphyrin biosynthesis" RELATED [] +synonym: "porphyrin biosynthetic process" RELATED [] +synonym: "porphyrin formation" RELATED [] +synonym: "porphyrin synthesis" RELATED [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0006780 +name: uroporphyrinogen III biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] +synonym: "uroporphyrinogen III anabolism" EXACT [] +synonym: "uroporphyrinogen III biosynthesis" EXACT [] +synonym: "uroporphyrinogen III formation" EXACT [] +synonym: "uroporphyrinogen III synthesis" EXACT [] +is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046502 ! uroporphyrinogen III metabolic process + +[Term] +id: GO:0006781 +name: succinyl-CoA pathway +namespace: biological_process +def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] +synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] +synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] +synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] +synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] +synonym: "succinyl CoA pathway" EXACT [] +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process +relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process + +[Term] +id: GO:0006782 +name: protoporphyrinogen IX biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] +synonym: "protoporphyrinogen IX anabolism" EXACT [] +synonym: "protoporphyrinogen IX biosynthesis" EXACT [] +synonym: "protoporphyrinogen IX formation" EXACT [] +synonym: "protoporphyrinogen IX synthesis" EXACT [] +is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process +is_a: GO:0046501 ! protoporphyrinogen IX metabolic process +relationship: part_of GO:0006783 ! heme biosynthetic process + +[Term] +id: GO:0006783 +name: heme biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl, PMID:11788607] +synonym: "haem biosynthesis" EXACT [] +synonym: "haem biosynthetic process" EXACT [] +synonym: "heme anabolism" EXACT [] +synonym: "heme biosynthesis" EXACT [] +synonym: "heme formation" EXACT [] +synonym: "heme synthesis" EXACT [] +xref: MetaCyc:HEMESYN2-PWY +is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process +is_a: GO:0042168 ! heme metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0006784 +name: heme A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3." [GOC:ai, PMID:11788607] +synonym: "haem A biosynthesis" EXACT [] +synonym: "haem A biosynthetic process" EXACT [] +synonym: "heme A anabolism" EXACT [] +synonym: "heme A biosynthesis" EXACT [] +synonym: "heme A formation" EXACT [] +synonym: "heme A synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046160 ! heme a metabolic process + +[Term] +id: GO:0006785 +name: heme B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, PMID:29414780, UniPathway:UPA00252] +synonym: "haem B biosynthesis" EXACT [] +synonym: "haem B biosynthetic process" EXACT [] +synonym: "heme B anabolism" EXACT [] +synonym: "heme B biosynthesis" EXACT [] +synonym: "heme B formation" EXACT [] +synonym: "heme B synthesis" EXACT [] +synonym: "protoheme biosynthesis" EXACT [] +synonym: "protoheme biosynthetic process" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046492 ! heme B metabolic process + +[Term] +id: GO:0006786 +name: heme C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] +synonym: "haem C biosynthesis" EXACT [] +synonym: "haem C biosynthetic process" EXACT [] +synonym: "heme C anabolism" EXACT [] +synonym: "heme C biosynthesis" EXACT [] +synonym: "heme C formation" EXACT [] +synonym: "heme C synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046162 ! heme C metabolic process + +[Term] +id: GO:0006787 +name: porphyrin-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] +synonym: "porphyrin breakdown" RELATED [] +synonym: "porphyrin catabolic process" RELATED [] +synonym: "porphyrin catabolism" RELATED [] +synonym: "porphyrin degradation" RELATED [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process +is_a: GO:0033015 ! tetrapyrrole catabolic process + +[Term] +id: GO:0006788 +name: heme oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] +synonym: "haem oxidation" EXACT [] +is_a: GO:0042168 ! heme metabolic process +relationship: part_of GO:0006787 ! porphyrin-containing compound catabolic process + +[Term] +id: GO:0006789 +name: bilirubin conjugation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6] +is_a: GO:0006787 ! porphyrin-containing compound catabolic process + +[Term] +id: GO:0006790 +name: sulfur compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +synonym: "sulfur metabolism" EXACT [] +synonym: "sulphur metabolic process" EXACT [] +synonym: "sulphur metabolism" EXACT [] +xref: Wikipedia:Sulfur_metabolism +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006791 +name: sulfur utilization +namespace: biological_process +def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] +synonym: "sulphur utilization" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0006792 +name: regulation of sulfur utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +synonym: "regulation of sulphur utilization" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0006793 +name: phosphorus metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] +subset: goslim_pir +synonym: "phosphorus metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0006794 +name: phosphorus utilization +namespace: biological_process +def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0006795 +name: regulation of phosphorus utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0006796 +name: phosphate-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] +synonym: "phosphate metabolic process" RELATED [] +synonym: "phosphate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0006797 +name: polyphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] +synonym: "polyphosphate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0006798 +name: polyphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] +synonym: "polyphosphate breakdown" EXACT [] +synonym: "polyphosphate catabolism" EXACT [] +synonym: "polyphosphate degradation" EXACT [] +is_a: GO:0006797 ! polyphosphate metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0006799 +name: polyphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732] +synonym: "polyphosphate anabolism" EXACT [] +synonym: "polyphosphate biosynthesis" EXACT [] +synonym: "polyphosphate formation" EXACT [] +synonym: "polyphosphate synthesis" EXACT [] +is_a: GO:0006797 ! polyphosphate metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0006800 +name: obsolete oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] +comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. +synonym: "oxygen and active oxygen species metabolism" EXACT [] +synonym: "oxygen and AOS metabolism" EXACT [] +synonym: "oxygen and reactive oxidative species metabolism" EXACT [] +synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] +synonym: "oxygen and reactive oxygen species metabolic process" EXACT [] +synonym: "oxygen and reactive oxygen species metabolism" EXACT [] +synonym: "oxygen and ROI metabolism" EXACT [] +synonym: "oxygen and ROS metabolic process" EXACT [] +synonym: "oxygen and ROS metabolism" EXACT [] +is_obsolete: true +consider: GO:0072592 +consider: GO:0072593 + +[Term] +id: GO:0006801 +name: superoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl] +synonym: "oxygen free radical metabolic process" EXACT [] +synonym: "oxygen free radical metabolism" EXACT [] +synonym: "superoxide free radical metabolic process" EXACT [] +synonym: "superoxide free radical metabolism" EXACT [] +synonym: "superoxide metabolism" EXACT [] +is_a: GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:0006802 +name: obsolete catalase reaction +namespace: biological_process +def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] +comment: This term was made obsolete because it represents a molecular function. +synonym: "catalase reaction" EXACT [] +synonym: "hydroperoxidase reaction" RELATED [] +is_obsolete: true +consider: GO:0004096 + +[Term] +id: GO:0006803 +name: obsolete glutathione conjugation reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "glutathione conjugation reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0004364 + +[Term] +id: GO:0006804 +name: obsolete peroxidase reaction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "peroxidase reaction" EXACT [] +is_obsolete: true +replaced_by: GO:0004601 + +[Term] +id: GO:0006805 +name: xenobiotic metabolic process +namespace: biological_process +alt_id: GO:0017144 +def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:cab2, GOC:krc] +subset: goslim_chembl +subset: goslim_pir +synonym: "drug metabolic process" RELATED [] +synonym: "drug metabolism" RELATED [] +synonym: "xenobiotic metabolism" EXACT [] +xref: Wikipedia:Drug_metabolism +xref: Wikipedia:Xenobiotic_metabolism +is_a: GO:0044237 ! cellular metabolic process +relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus + +[Term] +id: GO:0006806 +name: obsolete insecticide resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "insecticide resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0017085 + +[Term] +id: GO:0006807 +name: nitrogen compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [GOC:jl, ISBN:0198506732] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "nitrogen compound metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0006808 +name: regulation of nitrogen utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +subset: goslim_metagenomics +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0006809 +name: nitric oxide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +synonym: "nitric oxide anabolism" EXACT [] +synonym: "nitric oxide biosynthesis" EXACT [] +synonym: "nitric oxide formation" EXACT [] +synonym: "nitric oxide synthesis" EXACT [] +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:0006810 +name: transport +namespace: biological_process +alt_id: GO:0015457 +alt_id: GO:0015460 +alt_id: GO:0044765 +def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] +comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. +subset: gocheck_do_not_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "single-organism transport" RELATED [] +synonym: "small molecule transport" NARROW [] +synonym: "solute:solute exchange" NARROW [] +is_a: GO:0051234 ! establishment of localization + +[Term] +id: GO:0006811 +name: ion transport +namespace: biological_process +def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006812 +name: cation transport +namespace: biological_process +alt_id: GO:0006819 +alt_id: GO:0015674 +alt_id: GO:0072512 +def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] +synonym: "trivalent inorganic cation transport" NARROW [] +is_a: GO:0006811 ! ion transport + +[Term] +id: GO:0006813 +name: potassium ion transport +namespace: biological_process +alt_id: GO:0015458 +alt_id: GO:0071804 +def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "cellular potassium ion transport" EXACT [] +synonym: "K+ conductance" RELATED [] +synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] +synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] +synonym: "potassium conductance" NARROW [] +synonym: "potassium ion conductance" NARROW [] +synonym: "potassium transport" RELATED [] +synonym: "sodium/potassium transport" BROAD [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006814 +name: sodium ion transport +namespace: biological_process +alt_id: GO:0006834 +alt_id: GO:0016974 +def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] +synonym: "sodium transport" EXACT [] +synonym: "sodium/potassium transport" BROAD [] +synonym: "sodium:calcium exchange" NARROW [] +synonym: "sodium:solute transport" NARROW [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006815 +name: obsolete sodium/potassium transport +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +synonym: "sodium/potassium transport" EXACT [] +is_obsolete: true +consider: GO:0006813 +consider: GO:0006814 + +[Term] +id: GO:0006816 +name: calcium ion transport +namespace: biological_process +def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "calcium transport" EXACT [] +synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] +synonym: "sodium:calcium exchange" NARROW [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0006817 +name: phosphate ion transport +namespace: biological_process +def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "phosphate transport" RELATED [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0006820 +name: anion transport +namespace: biological_process +alt_id: GO:0006822 +def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006811 ! ion transport + +[Term] +id: GO:0006821 +name: chloride transport +namespace: biological_process +def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0006823 +name: obsolete heavy metal ion transport +namespace: biological_process +def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "heavy metal ion transport" EXACT [] +is_obsolete: true +consider: GO:0030001 + +[Term] +id: GO:0006824 +name: cobalt ion transport +namespace: biological_process +def: "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "cobalt transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0006825 +name: copper ion transport +namespace: biological_process +def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006826 +name: iron ion transport +namespace: biological_process +alt_id: GO:0015681 +alt_id: GO:0015682 +alt_id: GO:0015684 +alt_id: GO:0033216 +alt_id: GO:0097286 +def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "ferric ion import" NARROW [] +synonym: "ferric ion transport" NARROW [] +synonym: "ferric iron import" NARROW [] +synonym: "ferric iron transport" NARROW [] +synonym: "ferric iron uptake" NARROW [] +synonym: "ferrous ion transport" NARROW [] +synonym: "ferrous iron transport" NARROW [] +synonym: "iron ion import" RELATED [] +synonym: "iron transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006828 +name: manganese ion transport +namespace: biological_process +def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006829 +name: zinc ion transport +namespace: biological_process +def: "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "zinc II ion transport" EXACT [] +synonym: "zinc transport" EXACT [GOC:mah] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0006832 +name: obsolete small molecule transport +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "small molecule transport" EXACT [] +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0006833 +name: water transport +namespace: biological_process +def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0042044 ! fluid transport + +[Term] +id: GO:0006835 +name: dicarboxylic acid transport +namespace: biological_process +alt_id: GO:0006841 +def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "sodium:dicarboxylate transport" RELATED [] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006836 +name: neurotransmitter transport +namespace: biological_process +def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] +subset: goslim_pir +synonym: "sodium:neurotransmitter transport" NARROW [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006837 +name: serotonin transport +namespace: biological_process +def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0015844 ! monoamine transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0006838 +name: obsolete allantoin/allantoate transport +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +synonym: "allantoin/allantoate transport" EXACT [] +is_obsolete: true +consider: GO:0015719 +consider: GO:0015720 + +[Term] +id: GO:0006839 +name: mitochondrial transport +namespace: biological_process +def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] +subset: goslim_drosophila +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0006840 +name: obsolete mitochondrial alpha-ketoglutarate/malate transport +namespace: biological_process +def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "mitochondrial alpha-ketoglutarate/malate transport" EXACT [] +synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] +is_obsolete: true +consider: GO:0006839 +consider: GO:0015367 +consider: GO:0015742 +consider: GO:0015743 + +[Term] +id: GO:0006842 +name: tricarboxylic acid transport +namespace: biological_process +def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006843 +name: mitochondrial citrate transmembrane transport +namespace: biological_process +alt_id: GO:1990541 +def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix." [GOC:ai, PMID:20371607] +synonym: "mitochondrial citrate transport" RELATED [] +is_a: GO:0015746 ! citrate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1990546 ! mitochondrial tricarboxylic acid transmembrane transport + +[Term] +id: GO:0006844 +name: acyl carnitine transport +namespace: biological_process +def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] +is_a: GO:0015697 ! quaternary ammonium group transport + +[Term] +id: GO:0006845 +name: obsolete mitochondrial aspartate/glutamate transport +namespace: biological_process +def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "mitochondrial aspartate/glutamate transport" EXACT [] +is_obsolete: true +consider: GO:0006839 +consider: GO:0015810 +consider: GO:0015813 + +[Term] +id: GO:0006846 +name: acetate transport +namespace: biological_process +def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0006847 +name: plasma membrane acetate transport +namespace: biological_process +def: "The directed movement of acetate across a plasma membrane." [GOC:ai] +is_a: GO:0035433 ! acetate transmembrane transport + +[Term] +id: GO:0006848 +name: pyruvate transport +namespace: biological_process +def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0006849 +name: plasma membrane pyruvate transport +namespace: biological_process +def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] +is_a: GO:1901475 ! pyruvate transmembrane transport + +[Term] +id: GO:0006850 +name: mitochondrial pyruvate transmembrane transport +namespace: biological_process +alt_id: GO:1902361 +def: "The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558] +synonym: "mitochondrial pyruvate transport" RELATED [] +synonym: "pyruvate membrane transport in mitochondria" RELATED [] +synonym: "pyruvate membrane transport in mitochondrion" RELATED [] +synonym: "pyruvate transmembrane transport in mitochondria" RELATED [] +synonym: "pyruvate transmembrane transport in mitochondrion" RELATED [] +is_a: GO:1901475 ! pyruvate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0006851 +name: mitochondrial calcium ion transmembrane transport +namespace: biological_process +def: "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai] +synonym: "mitochondrial calcium transport" EXACT [] +is_a: GO:0070588 ! calcium ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0006852 +name: obsolete mitochondrial sodium/calcium ion exchange +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents function rather than a process. +synonym: "mitochondrial sodium/calcium exchange" EXACT [] +synonym: "mitochondrial sodium/calcium ion exchange" EXACT [] +is_obsolete: true +consider: GO:0005432 +consider: GO:0006814 +consider: GO:0006816 +consider: GO:0006839 + +[Term] +id: GO:0006853 +name: carnitine shuttle +namespace: biological_process +def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015909 ! long-chain fatty acid transport +is_a: GO:0032365 ! intracellular lipid transport +is_a: GO:1902001 ! fatty acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0006854 +name: obsolete ATP/ADP exchange +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "ATP/ADP exchange" EXACT [] +is_obsolete: true +replaced_by: GO:0005471 + +[Term] +id: GO:0006855 +name: xenobiotic transmembrane transport +namespace: biological_process +def: "The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:ai, GOC:bf, GOC:krc] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "drug membrane transport" EXACT [] +synonym: "drug transmembrane transport" RELATED [] +synonym: "multidrug transport" RELATED [] +is_a: GO:0042908 ! xenobiotic transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0006856 +name: eye pigment precursor transport +namespace: biological_process +def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006810 ! transport +relationship: part_of GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0006857 +name: oligopeptide transport +namespace: biological_process +def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0006858 +name: extracellular transport +namespace: biological_process +def: "The transport of substances that occurs outside cells." [GOC:go_curators] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0006859 +name: extracellular carbohydrate transport +namespace: biological_process +def: "The directed extracellular movement of carbohydrates." [GOC:ai] +is_a: GO:0006858 ! extracellular transport +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0006860 +name: extracellular amino acid transport +namespace: biological_process +def: "The directed extracellular movement of amino acids." [GOC:ai] +is_a: GO:0006858 ! extracellular transport +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0006862 +name: nucleotide transport +namespace: biological_process +def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732] +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0015931 ! nucleobase-containing compound transport + +[Term] +id: GO:0006863 +name: purine nucleobase transport +namespace: biological_process +alt_id: GO:0015852 +def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] +synonym: "purine base transmembrane transport" EXACT [GOC:mah] +synonym: "purine base transport" EXACT [GOC:go_curators] +synonym: "purine transmembrane transport" RELATED [GOC:mah] +synonym: "purine transport" RELATED [] +is_a: GO:0015851 ! nucleobase transport + +[Term] +id: GO:0006864 +name: pyrimidine nucleotide transport +namespace: biological_process +def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0006865 +name: amino acid transport +namespace: biological_process +alt_id: GO:0006866 +def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0015849 ! organic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0006867 +name: asparagine transport +namespace: biological_process +def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-asparagine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006868 +name: glutamine transport +namespace: biological_process +alt_id: GO:0015815 +def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-glutamine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0006869 +name: lipid transport +namespace: biological_process +def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0071702 ! organic substance transport +relationship: part_of GO:0010876 ! lipid localization + +[Term] +id: GO:0006873 +name: cellular ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah] +subset: goslim_yeast +is_a: GO:0050801 ! ion homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0006874 +name: cellular calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] +synonym: "regulation of calcium ion concentration" BROAD [] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0055074 ! calcium ion homeostasis +is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis + +[Term] +id: GO:0006875 +name: cellular metal ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "cellular heavy metal ion homeostasis" NARROW [] +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0006876 +name: cellular cadmium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "cadmium homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055073 ! cadmium ion homeostasis +is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis + +[Term] +id: GO:0006877 +name: cellular cobalt ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "cobalt homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055068 ! cobalt ion homeostasis + +[Term] +id: GO:0006878 +name: cellular copper ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "copper homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055070 ! copper ion homeostasis + +[Term] +id: GO:0006879 +name: cellular iron ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "iron homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055072 ! iron ion homeostasis + +[Term] +id: GO:0006880 +name: intracellular sequestering of iron ion +namespace: biological_process +def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] +synonym: "intracellular iron ion retention" EXACT [] +synonym: "intracellular iron ion sequestering" EXACT [] +synonym: "intracellular iron ion sequestration" EXACT [] +synonym: "intracellular iron ion storage" EXACT [] +synonym: "intracellular retention of iron ion" EXACT [] +synonym: "intracellular sequestration of iron ion" EXACT [] +synonym: "intracellular storage of iron ion" EXACT [] +is_a: GO:0097577 ! sequestering of iron ion + +[Term] +id: GO:0006881 +name: extracellular sequestering of iron ion +namespace: biological_process +def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai, GOC:cjm] +synonym: "extracellular iron ion retention" EXACT [] +synonym: "extracellular iron ion sequestering" EXACT [] +synonym: "extracellular iron ion sequestration" EXACT [] +synonym: "extracellular iron ion storage" EXACT [] +synonym: "extracellular retention of iron ion" EXACT [] +synonym: "extracellular sequestration of iron ion" EXACT [] +synonym: "extracellular storage of iron ion" EXACT [] +is_a: GO:0097577 ! sequestering of iron ion + +[Term] +id: GO:0006882 +name: cellular zinc ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] +synonym: "zinc homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055069 ! zinc ion homeostasis +is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis + +[Term] +id: GO:0006883 +name: cellular sodium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0055078 ! sodium ion homeostasis + +[Term] +id: GO:0006884 +name: cell volume homeostasis +namespace: biological_process +def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] +is_a: GO:0008361 ! regulation of cell size +is_a: GO:0019725 ! cellular homeostasis + +[Term] +id: GO:0006885 +name: regulation of pH +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0006886 +name: intracellular protein transport +namespace: biological_process +alt_id: GO:0032779 +def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] +subset: goslim_generic +synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] +is_a: GO:0015031 ! protein transport +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0034613 ! cellular protein localization + +[Term] +id: GO:0006887 +name: exocytosis +namespace: biological_process +alt_id: GO:0016194 +alt_id: GO:0016195 +def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] +subset: goslim_yeast +synonym: "nonselective vesicle exocytosis" RELATED [] +synonym: "vesicle exocytosis" EXACT [] +xref: Wikipedia:Exocytosis +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0006888 +name: endoplasmic reticulum to Golgi vesicle-mediated transport +namespace: biological_process +alt_id: GO:0048221 +def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] +synonym: "anterograde (ER to Golgi) transport" EXACT [] +synonym: "anterograde transport, endoplasmic reticulum to Golgi" EXACT [] +synonym: "anterograde transport, ER to Golgi" EXACT [] +synonym: "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi" EXACT [] +synonym: "anterograde vesicle-mediated transport, ER to Golgi" EXACT [] +synonym: "endoplasmic reticulum to Golgi transport" EXACT [] +synonym: "ER to Golgi transport" EXACT [] +synonym: "ER to Golgi vesicle-mediated transport" EXACT [] +synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] +synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] +synonym: "rough ER to cis-Golgi transport" EXACT [] +synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT [] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006889 +name: obsolete regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +synonym: "regulation of calcium in ER" EXACT [] +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0006890 +name: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum +namespace: biological_process +alt_id: GO:0048220 +def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] +synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] +synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] +synonym: "cis-Golgi to rough ER transport" EXACT [] +synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT [] +synonym: "retrograde (Golgi to ER) transport" EXACT [] +synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] +synonym: "retrograde transport, Golgi to ER" EXACT [] +synonym: "retrograde vesicle-mediated transport, Golgi to ER" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006891 +name: intra-Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] +synonym: "intra-Golgi transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006892 +name: post-Golgi vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] +synonym: "post-Golgi transport" EXACT [] +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0006893 +name: Golgi to plasma membrane transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] +synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport +is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane + +[Term] +id: GO:0006894 +name: obsolete Golgi to secretory vesicle transport +namespace: biological_process +def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] +comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. +synonym: "Golgi to secretory vesicle transport" EXACT [] +synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] +is_obsolete: true +consider: GO:0055107 +consider: GO:0055108 + +[Term] +id: GO:0006895 +name: Golgi to endosome transport +namespace: biological_process +alt_id: GO:0048218 +def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] +synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] +synonym: "TGN to endosome transport" EXACT [] +synonym: "trans-Golgi to endosome transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport +is_a: GO:0016482 ! cytosolic transport + +[Term] +id: GO:0006896 +name: Golgi to vacuole transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] +synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] +is_a: GO:0006892 ! post-Golgi vesicle-mediated transport +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0006897 +name: endocytosis +namespace: biological_process +alt_id: GO:0016193 +alt_id: GO:0016196 +alt_id: GO:0098701 +def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] +subset: goslim_yeast +synonym: "endocytic import into cell" EXACT [] +synonym: "nonselective vesicle endocytosis" RELATED [] +synonym: "plasma membrane invagination" NARROW [] +synonym: "vesicle endocytosis" EXACT [] +xref: Wikipedia:Endocytosis +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006898 +name: receptor-mediated endocytosis +namespace: biological_process +def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] +synonym: "receptor mediated endocytosis" EXACT [] +xref: Wikipedia:Receptor-mediated_endocytosis +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0006900 +name: vesicle budding from membrane +namespace: biological_process +alt_id: GO:0006902 +alt_id: GO:1902591 +def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] +synonym: "membrane evagination" EXACT [] +synonym: "nonselective vesicle assembly" RELATED [] +synonym: "single organism membrane budding" RELATED [GOC:TermGenie] +synonym: "single-organism membrane budding" RELATED [] +synonym: "vesicle biosynthesis" EXACT [] +synonym: "vesicle budding" RELATED [] +synonym: "vesicle formation" EXACT [] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006901 +name: vesicle coating +namespace: biological_process +def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] +synonym: "vesicle coat assembly" BROAD [] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0006900 ! vesicle budding from membrane + +[Term] +id: GO:0006903 +name: vesicle targeting +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0016192 ! vesicle-mediated transport +relationship: part_of GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:0006904 +name: vesicle docking involved in exocytosis +namespace: biological_process +def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:aruk, GOC:bc, GOC:jid, PMID:22438915] +synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0048278 ! vesicle docking +is_a: GO:0140029 ! exocytic process + +[Term] +id: GO:0006905 +name: obsolete vesicle transport +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "vesicle transport" EXACT [] +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0006906 +name: vesicle fusion +namespace: biological_process +def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0090174 ! organelle membrane fusion +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006907 +name: pinocytosis +namespace: biological_process +alt_id: GO:0006908 +alt_id: GO:1902536 +def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane." [ISBN:0198506732] +synonym: "clathrin-independent pinocytosis" BROAD [] +synonym: "fluid-phase endocytosis" EXACT [] +synonym: "single-organism pinocytosis" RELATED [] +xref: Wikipedia:Pinocytosis +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0006909 +name: phagocytosis +namespace: biological_process +def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] +xref: Wikipedia:Phagocytosis +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0006910 +name: phagocytosis, recognition +namespace: biological_process +def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149] +comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. +synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] +is_a: GO:0008037 ! cell recognition +relationship: part_of GO:0006897 ! endocytosis +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0006911 +name: phagocytosis, engulfment +namespace: biological_process +def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] +synonym: "phagosome biosynthesis" RELATED [] +synonym: "phagosome formation" RELATED [] +is_a: GO:0099024 ! plasma membrane invagination +relationship: part_of GO:0006897 ! endocytosis +relationship: part_of GO:0006909 ! phagocytosis + +[Term] +id: GO:0006912 +name: obsolete phagosome formation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:hjd] +comment: This term was made obsolete because of the ambiguity in its meaning. +synonym: "phagosome formation" EXACT [] +is_obsolete: true +consider: GO:0001845 +consider: GO:0006911 + +[Term] +id: GO:0006913 +name: nucleocytoplasmic transport +namespace: biological_process +alt_id: GO:0000063 +def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] +comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "nucleocytoplasmic shuttling" NARROW [] +is_a: GO:0051169 ! nuclear transport + +[Term] +id: GO:0006914 +name: autophagy +namespace: biological_process +alt_id: GO:0016238 +def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +xref: Wikipedia:Autophagy_(cellular) +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0061919 ! process utilizing autophagic mechanism + +[Term] +id: GO:0006915 +name: apoptotic process +namespace: biological_process +alt_id: GO:0006917 +alt_id: GO:0008632 +def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] +synonym: "activation of apoptosis" NARROW [] +synonym: "apoptosis" NARROW [] +synonym: "apoptosis activator activity" RELATED [] +synonym: "apoptosis signaling" NARROW [] +synonym: "apoptotic cell death" EXACT [GOC:sl] +synonym: "apoptotic program" NARROW [GOC:add] +synonym: "apoptotic programmed cell death" EXACT [] +synonym: "caspase-dependent programmed cell death" RELATED [] +synonym: "cell suicide" BROAD [] +synonym: "cellular suicide" BROAD [] +synonym: "commitment to apoptosis" RELATED [] +synonym: "induction of apoptosis" RELATED [] +synonym: "induction of apoptosis by p53" RELATED [] +synonym: "programmed cell death by apoptosis" EXACT [] +synonym: "signaling (initiator) caspase activity" RELATED [] +synonym: "type I programmed cell death" NARROW [] +xref: Wikipedia:Apoptosis +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0006918 +name: obsolete induction of apoptosis by p53 +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more accurate terms were created. +synonym: "induction of apoptosis by p53" EXACT [] +is_obsolete: true +consider: GO:0006915 + +[Term] +id: GO:0006919 +name: activation of cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] +comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase. +synonym: "activation of caspase activity" NARROW [] +synonym: "activation of metacaspase activity" NARROW [] +synonym: "caspase activation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:0006920 +name: obsolete commitment to apoptosis +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more accurate terms were created. +synonym: "commitment to apoptosis" EXACT [] +is_obsolete: true +consider: GO:0006915 + +[Term] +id: GO:0006921 +name: cellular component disassembly involved in execution phase of apoptosis +namespace: biological_process +def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] +synonym: "cellular component disassembly involved in apoptosis" NARROW [] +synonym: "cellular component disassembly involved in apoptotic process" BROAD [] +synonym: "disassembly of cell structures" BROAD [] +is_a: GO:0022411 ! cellular component disassembly +relationship: part_of GO:0097194 ! execution phase of apoptosis + +[Term] +id: GO:0006922 +name: obsolete cleavage of lamin involved in execution phase of apoptosis +namespace: biological_process +def: "OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, GOC:mtg_apoptosis, ISBN:0815332181] +comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. +synonym: "cleavage of lamin" BROAD [] +synonym: "cleavage of lamin involved in execution phase of apoptosis" EXACT [] +is_obsolete: true +consider: GO:0097200 + +[Term] +id: GO:0006923 +name: obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis +namespace: biological_process +def: "OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] +comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. +synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] +synonym: "cleavage of cytoskeletal proteins involved in apoptosis" BROAD [] +synonym: "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" EXACT [] +is_obsolete: true +consider: GO:0097200 + +[Term] +id: GO:0006924 +name: activation-induced cell death of T cells +namespace: biological_process +def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672] +synonym: "activated T cell apoptosis" BROAD [GOC:add] +synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add] +synonym: "activation-induced cell death of T-cells" EXACT [GOC:add] +synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add] +synonym: "AICD" BROAD [GOC:add] +synonym: "antigen-driven apoptosis" BROAD [GOC:add] +is_a: GO:0070231 ! T cell apoptotic process +relationship: part_of GO:0043029 ! T cell homeostasis + +[Term] +id: GO:0006925 +name: inflammatory cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis] +synonym: "apoptosis of inflammatory cells" EXACT [] +synonym: "inflammatory cell apoptosis" NARROW [] +synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] +synonym: "killing of inflammatory cells" EXACT [] +synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] +synonym: "programmed cell death, inflammatory cells" EXACT [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0006926 +name: obsolete virus-infected cell apoptotic process +namespace: biological_process +def: "OBSOLETE. Any apoptotic process in a cell infected with a virus." [GOC:jl, GOC:mtg_apoptosis] +comment: This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral process terms to annotate viral proteins. As for the cellular apoptotic process, this likely occurs via the same mechanisms described by existing apoptotic process terms, so please consider using those to annotate cellular proteins. +synonym: "apoptosis of virus-infected cells" EXACT [] +synonym: "killing virus-infected cells" EXACT [] +synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] +synonym: "programmed cell death, virus-infected cells" EXACT [] +synonym: "virus-infected cell apoptosis" NARROW [] +synonym: "virus-infected cell apoptotic process" EXACT [] +synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006927 +name: obsolete transformed cell apoptotic process +namespace: biological_process +def: "OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, GOC:mtg_apoptosis] +comment: This term was made obsolete because it does not refer to a normal process. +synonym: "apoptosis of transformed cells" EXACT [] +synonym: "killing transformed cells" EXACT [] +synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] +synonym: "programmed cell death, transformed cells" EXACT [] +synonym: "transformed cell apoptosis" NARROW [] +synonym: "transformed cell programmed cell death by apoptosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006928 +name: movement of cell or subcellular component +namespace: biological_process +def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] +comment: Note that in GO cellular components include whole cells (cell is_a cellular component). +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "cell movement" RELATED [] +synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] +synonym: "cellular component movement" EXACT [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0006929 +name: substrate-dependent cell migration +namespace: biological_process +def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration" EXACT [] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0006930 +name: substrate-dependent cell migration, cell extension +namespace: biological_process +def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration, cell extension" EXACT [] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly +relationship: part_of GO:0006929 ! substrate-dependent cell migration + +[Term] +id: GO:0006931 +name: substrate-dependent cell migration, cell attachment to substrate +namespace: biological_process +def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT [] +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0006929 ! substrate-dependent cell migration + +[Term] +id: GO:0006932 +name: substrate-dependent cell migration, cell contraction +namespace: biological_process +def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration, cell contraction" EXACT [] +is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility +relationship: part_of GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0006929 ! substrate-dependent cell migration + +[Term] +id: GO:0006933 +name: negative regulation of cell adhesion involved in substrate-bound cell migration +namespace: biological_process +def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] +synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007162 ! negative regulation of cell adhesion +relationship: part_of GO:0006929 ! substrate-dependent cell migration + +[Term] +id: GO:0006934 +name: substrate-bound cell migration, adhesion receptor recycling +namespace: biological_process +def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration + +[Term] +id: GO:0006935 +name: chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] +synonym: "taxis in response to chemical stimulus" EXACT [] +xref: Wikipedia:Chemotaxis +is_a: GO:0042330 ! taxis +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0006936 +name: muscle contraction +namespace: biological_process +def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] +subset: goslim_pir +xref: Wikipedia:Muscle_contraction +is_a: GO:0003012 ! muscle system process + +[Term] +id: GO:0006937 +name: regulation of muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] +is_a: GO:0090257 ! regulation of muscle system process +relationship: regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0006939 +name: smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] +synonym: "visceral muscle contraction" EXACT [] +is_a: GO:0006936 ! muscle contraction + +[Term] +id: GO:0006940 +name: regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +is_a: GO:0006937 ! regulation of muscle contraction +relationship: regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0006941 +name: striated muscle contraction +namespace: biological_process +def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] +synonym: "sarcomeric muscle contraction" EXACT [] +is_a: GO:0006936 ! muscle contraction + +[Term] +id: GO:0006942 +name: regulation of striated muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +is_a: GO:0006937 ! regulation of muscle contraction +relationship: regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0006943 +name: obsolete chemi-mechanical coupling +namespace: biological_process +def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com] +comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. +synonym: "chemi-mechanical coupling" EXACT [] +synonym: "mechanochemical coupling" EXACT [] +is_obsolete: true +consider: GO:0009612 +consider: GO:0050954 + +[Term] +id: GO:0006945 +name: obsolete nuclear fusion during karyogamy +namespace: biological_process +def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] +comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. +synonym: "nuclear fusion during karyogamy" EXACT [] +is_obsolete: true +consider: GO:0000741 + +[Term] +id: GO:0006948 +name: induction by virus of host cell-cell fusion +namespace: biological_process +def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] +comment: Where syncytium formation results in the spread of virus in the host, also consider annotating to the term 'spread of virus in multicellular host ; GO:0046739'. +synonym: "induction by virus of cell-cell fusion in host" EXACT [] +synonym: "viral-induced cell-cell fusion" EXACT [] +synonym: "viral-induced host cell-cell fusion" EXACT [] +synonym: "viral-induced membrane fusion" NARROW [] +is_a: GO:0019054 ! modulation by virus of host cellular process + +[Term] +id: GO:0006949 +name: syncytium formation +namespace: biological_process +def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] +subset: goslim_pir +is_a: GO:0009987 ! cellular process +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0006950 +name: response to stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_plant +synonym: "response to abiotic stress" RELATED [] +synonym: "response to biotic stress" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0006952 +name: defense response +namespace: biological_process +alt_id: GO:0002217 +alt_id: GO:0042829 +def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] +synonym: "antimicrobial peptide activity" RELATED [] +synonym: "defence response" EXACT [] +synonym: "defense/immunity protein activity" RELATED [] +synonym: "physiological defense response" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006953 +name: acute-phase response +namespace: biological_process +def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732] +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0006954 +name: inflammatory response +namespace: biological_process +def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, ISBN:0198506732] +subset: goslim_generic +synonym: "inflammation" BROAD [] +xref: Wikipedia:Inflammation +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0006955 +name: immune response +namespace: biological_process +def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add] +subset: goslim_drosophila +is_a: GO:0002376 ! immune system process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0006956 +name: complement activation +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "complement activity" RELATED [] +synonym: "complement cascade" EXACT [GOC:add] +synonym: "complement response" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0002253 ! activation of immune response +is_a: GO:0006959 ! humoral immune response + +[Term] +id: GO:0006957 +name: complement activation, alternative pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] +synonym: "complement cascade, alternative pathway" EXACT [GOC:add] +is_a: GO:0006956 ! complement activation +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0006958 +name: complement activation, classical pathway +namespace: biological_process +def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149] +synonym: "complement cascade, classical pathway" EXACT [GOC:add] +is_a: GO:0006956 ! complement activation +relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin + +[Term] +id: GO:0006959 +name: humoral immune response +namespace: biological_process +def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] +xref: Wikipedia:Humoral_immunity +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0006962 +name: male-specific antibacterial humoral response +namespace: biological_process +def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] +is_a: GO:0019731 ! antibacterial humoral response +is_a: GO:0050831 ! male-specific defense response to bacterium + +[Term] +id: GO:0006963 +name: positive regulation of antibacterial peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] +synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] +synonym: "antibacterial peptide induction" EXACT [] +synonym: "antibacterial polypeptide induction" EXACT [] +synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] +synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] +synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] +is_a: GO:0002803 ! positive regulation of antibacterial peptide production +is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process + +[Term] +id: GO:0006964 +name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] +synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] +synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] +synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] +synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] +is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria +is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria + +[Term] +id: GO:0006965 +name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] +synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] +synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] +synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] +synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] +is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria +is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process +relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria + +[Term] +id: GO:0006967 +name: positive regulation of antifungal peptide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] +synonym: "activation of antifungal peptide biosynthetic process" NARROW [] +synonym: "antifungal peptide induction" EXACT [] +synonym: "antifungal polypeptide induction" EXACT [] +synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] +synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] +synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] +is_a: GO:0002804 ! positive regulation of antifungal peptide production +is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process +is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process +relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process + +[Term] +id: GO:0006968 +name: cellular defense response +namespace: biological_process +alt_id: GO:0002818 +alt_id: GO:0016066 +alt_id: GO:0016067 +def: "A defense response that is mediated by cells." [GOC:ebc] +synonym: "cellular defence response" EXACT [] +synonym: "intracellular defence response" NARROW [] +synonym: "intracellular defense response" NARROW [] +is_a: GO:0006952 ! defense response + +[Term] +id: GO:0006969 +name: obsolete melanotic tumor response +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it was undefined and represented an abnormal process. +synonym: "melanotic mass response" EXACT [] +synonym: "melanotic tumor response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0006970 +name: response to osmotic stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] +subset: goslim_yeast +synonym: "osmotic response" EXACT [] +synonym: "osmotic stress response" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0006971 +name: hypotonic response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593] +synonym: "hypo-osmotic response" EXACT [] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0006972 +name: hyperosmotic response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] +synonym: "HOG response" EXACT [] +synonym: "hypertonic response" EXACT [] +synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0006973 +name: intracellular accumulation of glycerol +namespace: biological_process +def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] +is_a: GO:0019725 ! cellular homeostasis +relationship: part_of GO:0071474 ! cellular hyperosmotic response + +[Term] +id: GO:0006974 +name: cellular response to DNA damage stimulus +namespace: biological_process +alt_id: GO:0034984 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] +subset: goslim_yeast +synonym: "cellular DNA damage response" EXACT [] +synonym: "DNA damage response" EXACT [] +synonym: "response to DNA damage stimulus" BROAD [] +synonym: "response to genotoxic stress" EXACT [] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0006975 +name: DNA damage induced protein phosphorylation +namespace: biological_process +def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0006977 +name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest +namespace: biological_process +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] +synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah] +is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator +is_a: GO:0031571 ! mitotic G1 DNA damage checkpoint signaling + +[Term] +id: GO:0006978 +name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +namespace: biological_process +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] +is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator +is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription + +[Term] +id: GO:0006979 +name: response to oxidative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] +subset: goslim_yeast +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006981 +name: obsolete activation of SoxR protein +namespace: biological_process +def: "OBSOLETE. The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] +comment: This term was made obsolete because it was too specific with respect to a single gene product. +is_obsolete: true + +[Term] +id: GO:0006982 +name: response to lipid hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] +synonym: "response to LHPO" EXACT [] +is_a: GO:0033194 ! response to hydroperoxide +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0006983 +name: ER overload response +namespace: biological_process +alt_id: GO:0006985 +def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] +synonym: "endoplasmic reticulum overload response" EXACT [] +synonym: "EOR" EXACT [] +synonym: "EOR-mediated activation of NF-kappaB" NARROW [GOC:dph, GOC:tb] +synonym: "EOR-mediated NF-kappaB activation" NARROW [] +synonym: "ER-overload response" EXACT [] +synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of NF-kappaB transcription factor activity by ER overload response" NARROW [] +is_a: GO:0006984 ! ER-nucleus signaling pathway +is_a: GO:0034976 ! response to endoplasmic reticulum stress +is_a: GO:0071216 ! cellular response to biotic stimulus + +[Term] +id: GO:0006984 +name: ER-nucleus signaling pathway +namespace: biological_process +def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] +synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] +synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] +synonym: "ER to nucleus signaling pathway" EXACT [] +synonym: "ER to nucleus signalling pathway" EXACT [] +synonym: "ER-nuclear signaling pathway" EXACT [] +synonym: "ER-nuclear signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0006986 +name: response to unfolded protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] +comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0035966 ! response to topologically incorrect protein + +[Term] +id: GO:0006987 +name: obsolete activation of signaling protein activity involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] +comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). +synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] +synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] +synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] +is_obsolete: true +consider: GO:0036498 + +[Term] +id: GO:0006988 +name: obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" EXACT [] +is_obsolete: true +consider: GO:0004521 + +[Term] +id: GO:0006989 +name: obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" EXACT [] +is_obsolete: true +consider: GO:0008452 + +[Term] +id: GO:0006990 +name: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response +namespace: biological_process +def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763] +synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] +synonym: "unfolded protein response, activation of target gene transcription" NARROW [] +synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] +synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] +synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] +synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] +synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] +synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0006991 +name: response to sterol depletion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732] +synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0006995 +name: cellular response to nitrogen starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0043562 ! cellular response to nitrogen levels + +[Term] +id: GO:0006996 +name: organelle organization +namespace: biological_process +alt_id: GO:1902589 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_pir +synonym: "organelle organisation" EXACT [] +synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] +synonym: "single organism organelle organization" EXACT [GOC:TermGenie] +synonym: "single-organism organelle organization" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0006997 +name: nucleus organization +namespace: biological_process +alt_id: GO:0048287 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_yeast +synonym: "nuclear morphology" RELATED [] +synonym: "nuclear organisation" EXACT [] +synonym: "nuclear organization" EXACT [] +synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] +synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0006998 +name: nuclear envelope organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] +synonym: "nuclear envelope organisation" EXACT [GOC:mah] +synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0006997 ! nucleus organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0006999 +name: nuclear pore organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] +synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah] +synonym: "nuclear pore organisation" EXACT [] +synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0007000 +name: nucleolus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] +synonym: "nucleolus organisation" EXACT [] +synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0007002 +name: obsolete centromere binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "centromere binding" EXACT [] +is_obsolete: true +replaced_by: GO:0019237 + +[Term] +id: GO:0007003 +name: obsolete telomere binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "telomere binding" EXACT [] +is_obsolete: true +replaced_by: GO:0042162 + +[Term] +id: GO:0007004 +name: telomere maintenance via telomerase +namespace: biological_process +def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] +synonym: "telomerase-dependent telomere maintenance" EXACT [] +is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process +is_a: GO:0010833 ! telomere maintenance via telomere lengthening + +[Term] +id: GO:0007005 +name: mitochondrion organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +synonym: "mitochondria organization" EXACT [GOC:mah] +synonym: "mitochondrion organisation" EXACT [GOC:mah] +synonym: "mitochondrion organization and biogenesis" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007006 +name: mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "mitochondrial membrane organisation" EXACT [] +synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0007007 +name: inner mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "inner mitochondrial membrane organisation" EXACT [] +synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] +synonym: "mitochondrial inner membrane organization" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization + +[Term] +id: GO:0007008 +name: outer mitochondrial membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. +synonym: "outer mitochondrial membrane organisation" EXACT [] +synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007006 ! mitochondrial membrane organization + +[Term] +id: GO:0007009 +name: plasma membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_chembl +synonym: "plasma membrane organisation" EXACT [] +synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0007010 +name: cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_yeast +synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] +synonym: "cytoskeletal regulator activity" RELATED [] +synonym: "cytoskeleton organisation" EXACT [] +synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007011 +name: obsolete regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. +synonym: "regulation of cytoskeleton" EXACT [] +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0007014 +name: actin ubiquitination +namespace: biological_process +def: "The modification of actin by addition of ubiquitin groups." [GOC:mah] +synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah] +is_a: GO:0016567 ! protein ubiquitination +is_a: GO:0030047 ! actin modification + +[Term] +id: GO:0007015 +name: actin filament organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] +synonym: "actin filament organisation" EXACT [] +synonym: "regulation of actin filament localization" NARROW [] +is_a: GO:0097435 ! supramolecular fiber organization +relationship: part_of GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0007016 +name: obsolete cytoskeletal anchoring at plasma membrane +namespace: biological_process +def: "OBSOLETE. A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] +comment: This term was obsoleted because it represents a molecular function. +synonym: "cytoskeletal anchoring activity" RELATED [] +is_obsolete: true +consider: GO:0007010 +consider: GO:0106006 + +[Term] +id: GO:0007017 +name: microtubule-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] +subset: goslim_chembl +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007018 +name: microtubule-based movement +namespace: biological_process +def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] +subset: goslim_drosophila +subset: goslim_generic +is_a: GO:0006928 ! movement of cell or subcellular component +is_a: GO:0007017 ! microtubule-based process + +[Term] +id: GO:0007019 +name: microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] +synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] +synonym: "microtubule depolymerization during nuclear congression" NARROW [] +synonym: "microtubule disassembly" EXACT [] +synonym: "microtubule shortening" EXACT [] +is_a: GO:0031109 ! microtubule polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0007020 +name: microtubule nucleation +namespace: biological_process +def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] +xref: Wikipedia:Microtubule_nucleation +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0007021 +name: tubulin complex assembly +namespace: biological_process +def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] +synonym: "tubulin assembly" EXACT [] +synonym: "tubulin folding" RELATED [] +synonym: "tubulin-specific chaperone activity" RELATED [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0007023 +name: post-chaperonin tubulin folding pathway +namespace: biological_process +def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0007026 +name: negative regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] +synonym: "down regulation of microtubule depolymerization" EXACT [] +synonym: "down-regulation of microtubule depolymerization" EXACT [] +synonym: "downregulation of microtubule depolymerization" EXACT [] +synonym: "inhibition of microtubule depolymerization" NARROW [] +synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] +synonym: "microtubule stabilization" EXACT [] +synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of microtubule disassembly" EXACT [] +is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization +is_a: GO:0031114 ! regulation of microtubule depolymerization +is_a: GO:1901880 ! negative regulation of protein depolymerization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0007027 +name: negative regulation of axonemal microtubule depolymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] +synonym: "axonemal microtubule stabilization" EXACT [] +synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] +is_a: GO:0007026 ! negative regulation of microtubule depolymerization +is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization + +[Term] +id: GO:0007028 +name: cytoplasm organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "cytoplasm organisation" EXACT [] +synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0007029 +name: endoplasmic reticulum organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "endoplasmic reticulum morphology" RELATED [] +synonym: "endoplasmic reticulum organisation" EXACT [] +synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] +synonym: "ER organisation" EXACT [] +synonym: "ER organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0007030 +name: Golgi organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "Golgi organisation" EXACT [] +synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0007031 +name: peroxisome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +synonym: "peroxisome organisation" EXACT [] +synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] +synonym: "peroxisome-assembly ATPase activity" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007032 +name: endosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "endosome organisation" EXACT [] +synonym: "endosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0007033 +name: vacuole organization +namespace: biological_process +alt_id: GO:0044086 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_yeast +synonym: "vacuolar assembly" NARROW [GOC:mah] +synonym: "vacuole biogenesis" RELATED [GOC:mah] +synonym: "vacuole organisation" EXACT [] +synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0007034 +name: vacuolar transport +namespace: biological_process +def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] +subset: goslim_chembl +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0007035 +name: vacuolar acidification +namespace: biological_process +def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] +is_a: GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0007036 +name: vacuolar calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0007038 +name: endocytosed protein transport to vacuole +namespace: biological_process +def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] +comment: See also the biological process term 'endocytosis ; GO:0006897'. +synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0007039 +name: protein catabolic process in the vacuole +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] +synonym: "vacuolar protein breakdown" RELATED [] +synonym: "vacuolar protein catabolic process" RELATED [] +synonym: "vacuolar protein catabolism" RELATED [] +synonym: "vacuolar protein degradation" RELATED [] +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0007040 +name: lysosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] +subset: goslim_generic +synonym: "lysosome organisation" EXACT [] +synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0080171 ! lytic vacuole organization + +[Term] +id: GO:0007041 +name: lysosomal transport +namespace: biological_process +def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0007042 +name: lysosomal lumen acidification +namespace: biological_process +def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] +synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph] +is_a: GO:0007035 ! vacuolar acidification +is_a: GO:0035751 ! regulation of lysosomal lumen pH + +[Term] +id: GO:0007043 +name: cell-cell junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] +synonym: "intercellular junction assembly" EXACT [] +is_a: GO:0034329 ! cell junction assembly +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0007044 +name: cell-substrate junction assembly +namespace: biological_process +alt_id: GO:0007045 +def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] +comment: The primary label for merged term was 'cell-substrate adherens junction assembly' GO:0007045. The term was merged into the parent 'cell-substrate junction assembly', because, based on the most recent litarature, 'adherens junction' is always a 'cell-cell junction' (PMID:20571587, PMID:17854762, PMID:21422226, PMID:28096264, PMID:28401269, PMID:26923917). +synonym: "cell-substrate adherens junction assembly" RELATED [] +is_a: GO:0034329 ! cell junction assembly +is_a: GO:0150115 ! cell-substrate junction organization + +[Term] +id: GO:0007048 +name: obsolete oncogenesis +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a pathological process. +synonym: "oncogenesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007049 +name: cell cycle +namespace: biological_process +def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] +subset: gocheck_do_not_manually_annotate +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_pir +subset: goslim_plant +synonym: "cell-division cycle" EXACT [] +xref: Wikipedia:Cell_cycle +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007051 +name: spindle organization +namespace: biological_process +alt_id: GO:0043146 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] +synonym: "spindle organisation" EXACT [] +synonym: "spindle organization and biogenesis" RELATED [GOC:mah] +synonym: "spindle stabilization" RELATED [] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0007052 +name: mitotic spindle organization +namespace: biological_process +alt_id: GO:0000071 +alt_id: GO:0030472 +alt_id: GO:0043148 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] +comment: In fission yeast most mitotic spindle organization occurs in the nucleus. +synonym: "mitotic spindle organisation" EXACT [] +synonym: "mitotic spindle organisation in nucleus" NARROW [] +synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] +synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW [] +synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW [] +synonym: "mitotic spindle organization in nucleus" NARROW [] +synonym: "mitotic spindle stabilization" RELATED [] +synonym: "spindle organization and biogenesis during mitosis" EXACT [] +synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW [] +is_a: GO:0007051 ! spindle organization +is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis + +[Term] +id: GO:0007053 +name: spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0090306 ! meiotic spindle assembly +relationship: part_of GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007054 +name: spindle assembly involved in male meiosis I +namespace: biological_process +def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] +synonym: "male meiosis I spindle assembly" RELATED [] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +relationship: part_of GO:0007141 ! male meiosis I + +[Term] +id: GO:0007055 +name: spindle assembly involved in male meiosis II +namespace: biological_process +def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] +synonym: "male meiosis II spindle assembly" RELATED [] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +relationship: part_of GO:0007142 ! male meiosis II + +[Term] +id: GO:0007056 +name: spindle assembly involved in female meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] +synonym: "female meiotic spindle assembly" RELATED [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0090306 ! meiotic spindle assembly +relationship: part_of GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0007057 +name: spindle assembly involved in female meiosis I +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] +synonym: "female meiosis I spindle assembly" RELATED [] +is_a: GO:0007056 ! spindle assembly involved in female meiosis +relationship: part_of GO:0007144 ! female meiosis I + +[Term] +id: GO:0007058 +name: spindle assembly involved in female meiosis II +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] +synonym: "female meiosis II spindle assembly" RELATED [] +is_a: GO:0007056 ! spindle assembly involved in female meiosis +relationship: part_of GO:0007147 ! female meiosis II + +[Term] +id: GO:0007059 +name: chromosome segregation +namespace: biological_process +def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_yeast +synonym: "chromosome division" EXACT [] +synonym: "chromosome transmission" RELATED [] +xref: Wikipedia:Chromosome_segregation +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007060 +name: male meiosis chromosome segregation +namespace: biological_process +def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045132 ! meiotic chromosome segregation +relationship: part_of GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007062 +name: sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194] +synonym: "coheson-mediated DNA tethering" EXACT [] +synonym: "sister chromatid alignment" RELATED [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0007063 +name: regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0007064 +name: mitotic sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] +is_a: GO:0007062 ! sister chromatid cohesion +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007065 +name: male meiosis sister chromatid cohesion +namespace: biological_process +def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007066 +name: female meiosis sister chromatid cohesion +namespace: biological_process +def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0007068 +name: obsolete negative regulation of transcription during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah] +synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah] +synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah] +synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah] +synonym: "mitotic repression of transcription" EXACT [] +synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0000122 +consider: GO:0044772 + +[Term] +id: GO:0007069 +name: obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] +synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] +synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0016479 +consider: GO:0044772 + +[Term] +id: GO:0007070 +name: obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] +synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] +synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0000122 +consider: GO:0044772 + +[Term] +id: GO:0007071 +name: obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] +synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] +synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0016480 +consider: GO:0044772 + +[Term] +id: GO:0007072 +name: positive regulation of transcription involved in exit from mitosis +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0010458 ! exit from mitosis + +[Term] +id: GO:0007073 +name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] +is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis + +[Term] +id: GO:0007074 +name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] +is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis + +[Term] +id: GO:0007075 +name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] +synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] +is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis + +[Term] +id: GO:0007076 +name: mitotic chromosome condensation +namespace: biological_process +def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] +is_a: GO:0030261 ! chromosome condensation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007077 +name: mitotic nuclear membrane disassembly +namespace: biological_process +def: "The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis." [GOC:bf, PMID:32848252] +synonym: "local NEB" BROAD [] +synonym: "mitotic nuclear envelope breakdown" EXACT [] +synonym: "mitotic nuclear envelope catabolism" RELATED [] +synonym: "mitotic nuclear envelope degradation" RELATED [] +synonym: "mitotic nuclear envelope disassembly" RELATED [] +synonym: "NEB" BROAD [] +synonym: "nuclear envelope breakdown" BROAD [] +is_a: GO:0051081 ! nuclear membrane disassembly +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0007078 +name: lamin depolymerization +namespace: biological_process +def: "The cell cycle process in which lamin is depolymerized." [GOC:jid] +is_a: GO:0051261 ! protein depolymerization +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007077 ! mitotic nuclear membrane disassembly + +[Term] +id: GO:0007079 +name: mitotic chromosome movement towards spindle pole +namespace: biological_process +alt_id: GO:0007082 +def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] +synonym: "chromosome migration to spindle pole during mitosis" EXACT [] +synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] +synonym: "mitotic chromosome movement" BROAD [] +synonym: "mitotic chromosome movement to spindle pole" EXACT [] +synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] +synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] +is_a: GO:0051305 ! chromosome movement towards spindle pole +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007080 +name: mitotic metaphase plate congression +namespace: biological_process +def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] +is_a: GO:0051310 ! metaphase plate congression +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007081 +name: obsolete mitotic sister-chromatid adhesion release +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. +synonym: "mitotic sister-chromatid adhesion release" EXACT [] +is_obsolete: true +consider: GO:0000070 +consider: GO:0007064 + +[Term] +id: GO:0007083 +name: mitotic chromosome decondensation +namespace: biological_process +def: "The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] +is_a: GO:0051312 ! chromosome decondensation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0007084 +name: mitotic nuclear membrane reassembly +namespace: biological_process +def: "The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge." [PMID:26040712, PMID:28242692, PMID:32109380, PMID:32848252] +synonym: "mitotic nuclear envelope reassembly" RELATED [] +synonym: "nuclear envelope repair" BROAD [] +synonym: "nuclear envelope resealing" BROAD [] +is_a: GO:0031468 ! nuclear membrane reassembly +is_a: GO:0101024 ! mitotic nuclear membrane organization + +[Term] +id: GO:0007085 +name: obsolete nuclear membrane vesicle binding to chromatin +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a molecular function. +synonym: "nuclear membrane vesicle binding to chromatin" EXACT [] +is_obsolete: true +consider: GO:0003682 + +[Term] +id: GO:0007086 +name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly +namespace: biological_process +def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah] +is_a: GO:0000740 ! nuclear membrane fusion +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0101024 ! mitotic nuclear membrane organization +relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly + +[Term] +id: GO:0007087 +name: mitotic nuclear pore complex reassembly +namespace: biological_process +def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai] +is_a: GO:0051292 ! nuclear pore complex assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly + +[Term] +id: GO:0007088 +name: regulation of mitotic nuclear division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] +synonym: "regulation of mitosis" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051783 ! regulation of nuclear division +relationship: regulates GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0007089 +name: traversing start control point of mitotic cell cycle +namespace: biological_process +alt_id: GO:0000081 +def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle] +is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle + +[Term] +id: GO:0007090 +name: obsolete regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "regulation of S-phase of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0044772 + +[Term] +id: GO:0007091 +name: metaphase/anaphase transition of mitotic cell cycle +namespace: biological_process +def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] +synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] +synonym: "mitotic metaphase/anaphase transition" EXACT [] +is_a: GO:0010965 ! regulation of mitotic sister chromatid separation +is_a: GO:0044772 ! mitotic cell cycle phase transition +is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle + +[Term] +id: GO:0007093 +name: mitotic cell cycle checkpoint signaling +namespace: biological_process +alt_id: GO:0031575 +alt_id: GO:0071780 +alt_id: GO:0072413 +alt_id: GO:0072456 +alt_id: GO:0072474 +def: "A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] +subset: gocheck_do_not_annotate +synonym: "mitotic cell cycle checkpoint" EXACT [] +synonym: "mitotic checkpoint" RELATED [] +synonym: "signal transduction involved in mitotic cell cycle checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic cell cycle G1/S checkpoint" NARROW [] +synonym: "signal transduction involved in mitotic G2/M transition checkpoint" NARROW [] +is_a: GO:0000075 ! cell cycle checkpoint signaling +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0007094 +name: mitotic spindle assembly checkpoint signaling +namespace: biological_process +alt_id: GO:0044810 +alt_id: GO:0072480 +alt_id: GO:1902420 +def: "A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] +synonym: "Dma1-dependent checkpoint" NARROW [] +synonym: "Mad2-dependent checkpoint" NARROW [] +synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT [] +synonym: "mitotic checkpoint" EXACT [] +synonym: "mitotic spindle assembly checkpoint" EXACT [] +synonym: "mitotic spindle assembly checkpoint signalling" EXACT [] +synonym: "SAC-independent checkpoint" NARROW [] +synonym: "signal transduction involved in Dma1-dependent checkpoint" NARROW [] +synonym: "signal transduction involved in mitotic cell cycle spindle assembly checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic spindle assembly checkpoint" EXACT [] +synonym: "signal transduction involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] +synonym: "signaling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie] +synonym: "signaling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] +synonym: "signaling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "signaling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] +synonym: "signalling cascade involved in Dma1-dependent checkpoint" NARROW [GOC:TermGenie] +synonym: "signalling cascade involved in SAC-independent checkpoint" NARROW [GOC:TermGenie] +synonym: "signalling pathway involved in Dma1-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "signalling pathway involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] +is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition +is_a: GO:0071173 ! spindle assembly checkpoint signaling +is_a: GO:0071174 ! mitotic spindle checkpoint signaling + +[Term] +id: GO:0007095 +name: mitotic G2 DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:0031572 +alt_id: GO:0072425 +alt_id: GO:0072434 +alt_id: GO:1902504 +alt_id: GO:1902505 +alt_id: GO:1902506 +def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle, PMID:16299494] +synonym: "down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "G2 DNA damage checkpoint" RELATED [] +synonym: "G2/M transition DNA damage checkpoint" EXACT [] +synonym: "inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT [] +synonym: "mitotic G2 DNA damage checkpoint" EXACT [] +synonym: "negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [] +synonym: "negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [] +synonym: "positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "regulation of signal transduction involved in mitotic G2 DNA damage checkpoint" NARROW [] +synonym: "regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "signal transduction involved in G2 DNA damage checkpoint" EXACT [] +synonym: "signal transduction involved in G2/M transition DNA damage checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic G2 DNA damage checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic G2/M transition DNA damage checkpoint" EXACT [] +is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling +is_a: GO:0044818 ! mitotic G2/M transition checkpoint + +[Term] +id: GO:0007096 +name: regulation of exit from mitosis +namespace: biological_process +def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +relationship: regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0007097 +name: nuclear migration +namespace: biological_process +alt_id: GO:0040023 +def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] +subset: goslim_aspergillus +synonym: "establishment of cell nucleus localization" RELATED [] +synonym: "establishment of localization of nucleus" RELATED [] +synonym: "establishment of nucleus localisation" RELATED [GOC:mah] +synonym: "establishment of nucleus localization" RELATED [] +synonym: "establishment of position of nucleus" EXACT [] +synonym: "nuclear movement" EXACT [] +synonym: "nuclear positioning" EXACT [] +synonym: "nucleus migration" EXACT [] +synonym: "nucleus positioning" EXACT [] +synonym: "positioning of nucleus" EXACT [] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0051647 ! nucleus localization +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0007098 +name: centrosome cycle +namespace: biological_process +alt_id: GO:0051297 +def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] +synonym: "centrosome organisation" EXACT [] +synonym: "centrosome organization" EXACT [] +synonym: "centrosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0007099 +name: centriole replication +namespace: biological_process +alt_id: GO:0032054 +def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124] +synonym: "centriole duplication" EXACT [] +synonym: "ciliary basal body duplication" RELATED [] +synonym: "microtubule basal body duplication" BROAD [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0098534 ! centriole assembly +relationship: part_of GO:0051298 ! centrosome duplication + +[Term] +id: GO:0007100 +name: mitotic centrosome separation +namespace: biological_process +def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] +is_a: GO:0051299 ! centrosome separation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0007101 +name: obsolete male meiosis centrosome cycle +namespace: biological_process +def: "OBSOLETE. Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah] +comment: false +synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0007105 +name: cytokinesis, site selection +namespace: biological_process +alt_id: GO:0010687 +def: "The process of marking the place where cytokinesis will occur." [GOC:mtg_cell_cycle] +synonym: "site selection involved in cell cycle cytokinesis" EXACT [] +synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0007106 +name: obsolete cytokinesis, protein recruitment +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was not defined. +synonym: "cytokinesis, protein recruitment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007107 +name: membrane addition at site of cytokinesis +namespace: biological_process +def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] +synonym: "cytokinesis, membrane recruitment/generation" EXACT [] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0007108 +name: obsolete cytokinesis, initiation of separation +namespace: biological_process +def: "OBSOLETE. The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] +comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. +synonym: "cytokinesis, initiation of separation" EXACT [] +synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0007109 +name: obsolete cytokinesis, completion of separation +namespace: biological_process +def: "OBSOLETE. The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] +comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. +synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] +synonym: "cytokinesis, completion of separation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007110 +name: meiosis I cytokinesis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] +synonym: "cytokinesis after meiosis I" EXACT [] +is_a: GO:0033206 ! meiotic cytokinesis +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0007111 +name: meiosis II cytokinesis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] +synonym: "cytokinesis after meiosis II" EXACT [] +is_a: GO:0033206 ! meiotic cytokinesis +is_a: GO:0061983 ! meiosis II cell cycle process + +[Term] +id: GO:0007112 +name: male meiosis cytokinesis +namespace: biological_process +def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] +synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] +synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0033206 ! meiotic cytokinesis +relationship: part_of GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007113 +name: endomitotic cell cycle +namespace: biological_process +def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] +comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. +synonym: "endomitosis" RELATED [] +xref: Wikipedia:Mitosis#Endomitosis +is_a: GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007114 +name: cell budding +namespace: biological_process +def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732] +subset: goslim_candida +subset: goslim_yeast +synonym: "budding" BROAD [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0032505 ! reproduction of a single-celled organism +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0007115 +name: obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents two processes. +synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" EXACT [] +is_obsolete: true +consider: GO:0000282 +consider: GO:0030010 + +[Term] +id: GO:0007116 +name: regulation of cell budding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] +synonym: "regulation of budding" BROAD [] +is_a: GO:0051302 ! regulation of cell division +is_a: GO:1903664 ! regulation of asexual reproduction +relationship: regulates GO:0007114 ! cell budding + +[Term] +id: GO:0007117 +name: budding cell bud growth +namespace: biological_process +def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] +synonym: "bud growth" BROAD [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0040007 ! growth +relationship: part_of GO:0007114 ! cell budding + +[Term] +id: GO:0007118 +name: budding cell apical bud growth +namespace: biological_process +def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] +synonym: "apical bud growth" BROAD [] +is_a: GO:0007117 ! budding cell bud growth + +[Term] +id: GO:0007119 +name: budding cell isotropic bud growth +namespace: biological_process +def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] +synonym: "isotropic bud growth" BROAD [] +is_a: GO:0007117 ! budding cell bud growth + +[Term] +id: GO:0007120 +name: axial cellular bud site selection +namespace: biological_process +def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] +synonym: "axial bud site selection" EXACT [] +synonym: "axial budding" BROAD [] +is_a: GO:0000282 ! cellular bud site selection +is_a: GO:0007114 ! cell budding + +[Term] +id: GO:0007121 +name: bipolar cellular bud site selection +namespace: biological_process +def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] +synonym: "bipolar bud site selection" EXACT [] +synonym: "bipolar budding" BROAD [] +synonym: "polar budding" BROAD [] +is_a: GO:0000282 ! cellular bud site selection +is_a: GO:0007114 ! cell budding + +[Term] +id: GO:0007122 +name: obsolete loss of asymmetric budding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a phenotype rather than a biological process. +synonym: "loss of asymmetric budding" EXACT [] +is_obsolete: true +consider: GO:0006033 + +[Term] +id: GO:0007123 +name: obsolete bud scar accumulation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a phenotype rather than a biological process. +synonym: "bud scar accumulation" EXACT [] +is_obsolete: true +consider: GO:0000282 + +[Term] +id: GO:0007124 +name: pseudohyphal growth +namespace: biological_process +def: "The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli." [GOC:krc, PMID:11104818, PMID:19347739, PMID:24710476] +subset: goslim_candida +subset: goslim_yeast +is_a: GO:0016049 ! cell growth +is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0007125 +name: obsolete invasive growth +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it has been split into two new terms. +synonym: "invasive growth" EXACT [] +is_obsolete: true +consider: GO:0001403 +consider: GO:0044409 + +[Term] +id: GO:0007127 +name: meiosis I +namespace: biological_process +def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] +synonym: "meiosis I nuclear division" EXACT [] +xref: Wikipedia:Meiosis#Meiosis_I +is_a: GO:0061982 ! meiosis I cell cycle process +is_a: GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0007128 +name: meiotic prophase I +namespace: biological_process +def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051324 ! prophase +is_a: GO:0098764 ! meiosis I cell cycle phase + +[Term] +id: GO:0007129 +name: homologous chromosome pairing at meiosis +namespace: biological_process +def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617, PMID:31811152] +synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "chromosomal synapsis" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "synapsis" NARROW [] +xref: Wikipedia:Synapsis +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0007130 +name: synaptonemal complex assembly +namespace: biological_process +def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732] +synonym: "synaptonemal complex formation" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +is_a: GO:0070193 ! synaptonemal complex organization +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis + +[Term] +id: GO:0007131 +name: reciprocal meiotic recombination +namespace: biological_process +alt_id: GO:0000021 +alt_id: GO:0007145 +def: "The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] +synonym: "female meiotic recombination" NARROW [] +synonym: "gene conversion with reciprocal crossover" EXACT [] +is_a: GO:0140527 ! reciprocal homologous recombination +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0007132 +name: meiotic metaphase I +namespace: biological_process +def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051323 ! metaphase +is_a: GO:0098764 ! meiosis I cell cycle phase + +[Term] +id: GO:0007133 +name: meiotic anaphase I +namespace: biological_process +def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051322 ! anaphase +is_a: GO:0098764 ! meiosis I cell cycle phase + +[Term] +id: GO:0007134 +name: meiotic telophase I +namespace: biological_process +def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051326 ! telophase +is_a: GO:0098764 ! meiosis I cell cycle phase + +[Term] +id: GO:0007135 +name: meiosis II +namespace: biological_process +def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] +synonym: "meiosis II nuclear division" EXACT [] +xref: Wikipedia:Meiosis#Meiosis_II +is_a: GO:0061983 ! meiosis II cell cycle process +is_a: GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0007136 +name: meiotic prophase II +namespace: biological_process +def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051324 ! prophase +is_a: GO:0098765 ! meiosis II cell cycle phase + +[Term] +id: GO:0007137 +name: meiotic metaphase II +namespace: biological_process +def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051323 ! metaphase +is_a: GO:0098765 ! meiosis II cell cycle phase + +[Term] +id: GO:0007138 +name: meiotic anaphase II +namespace: biological_process +def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051322 ! anaphase +is_a: GO:0098765 ! meiosis II cell cycle phase + +[Term] +id: GO:0007139 +name: meiotic telophase II +namespace: biological_process +def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051326 ! telophase +is_a: GO:0098765 ! meiosis II cell cycle phase + +[Term] +id: GO:0007140 +name: male meiotic nuclear division +namespace: biological_process +def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] +synonym: "male meiosis" RELATED [] +synonym: "male nuclear division" BROAD [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0140013 ! meiotic nuclear division +relationship: part_of GO:0048232 ! male gamete generation + +[Term] +id: GO:0007141 +name: male meiosis I +namespace: biological_process +def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] +synonym: "male meiosis I nuclear division" EXACT [] +is_a: GO:0007127 ! meiosis I +is_a: GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007142 +name: male meiosis II +namespace: biological_process +def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] +synonym: "male meiosis II nuclear division" EXACT [] +is_a: GO:0007135 ! meiosis II +is_a: GO:0007140 ! male meiotic nuclear division + +[Term] +id: GO:0007143 +name: female meiotic nuclear division +namespace: biological_process +def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] +comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. +synonym: "female meiosis" BROAD [] +synonym: "female meiotic division" BROAD [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0140013 ! meiotic nuclear division +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0007144 +name: female meiosis I +namespace: biological_process +def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] +synonym: "female meiosis I nuclear division" EXACT [] +is_a: GO:0007127 ! meiosis I +is_a: GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0007146 +name: meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] +is_a: GO:0000707 ! meiotic DNA recombinase assembly + +[Term] +id: GO:0007147 +name: female meiosis II +namespace: biological_process +def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] +synonym: "female meiosis II nuclear division" EXACT [] +is_a: GO:0007135 ! meiosis II +is_a: GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0007149 +name: obsolete colony morphology +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it describes a phenotype rather than a biological goal. +synonym: "colony morphology" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007150 +name: obsolete growth pattern +namespace: biological_process +def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid] +comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. +synonym: "growth pattern" EXACT [] +is_obsolete: true +consider: GO:0040007 + +[Term] +id: GO:0007154 +name: cell communication +namespace: biological_process +def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] +subset: goslim_pir +subset: goslim_plant +xref: Wikipedia:Cell_signaling +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007155 +name: cell adhesion +namespace: biological_process +alt_id: GO:0098602 +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_pombe +synonym: "cell adhesion molecule activity" RELATED [] +synonym: "single organism cell adhesion" RELATED [] +xref: Wikipedia:Cell_adhesion +is_a: GO:0009987 ! cellular process +is_a: GO:0022610 ! biological adhesion + +[Term] +id: GO:0007156 +name: homophilic cell adhesion via plasma membrane adhesion molecules +namespace: biological_process +def: "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules + +[Term] +id: GO:0007157 +name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules +namespace: biological_process +def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] +synonym: "agglutination" RELATED [GOC:mah] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules + +[Term] +id: GO:0007158 +name: neuron cell-cell adhesion +namespace: biological_process +def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] +synonym: "neuron adhesion" EXACT [] +synonym: "neuronal cell adhesion" EXACT [] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0007159 +name: leukocyte cell-cell adhesion +namespace: biological_process +def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] +synonym: "leukocyte adhesion" EXACT [] +synonym: "leukocyte cell adhesion" EXACT [] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0007160 +name: cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] +is_a: GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0007161 +name: calcium-independent cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-independent cell adhesion molecule activity" RELATED [] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0007162 +name: negative regulation of cell adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] +synonym: "cell adhesion receptor inhibitor activity" RELATED [] +synonym: "down regulation of cell adhesion" EXACT [] +synonym: "down-regulation of cell adhesion" EXACT [] +synonym: "downregulation of cell adhesion" EXACT [] +synonym: "inhibition of cell adhesion" NARROW [] +is_a: GO:0030155 ! regulation of cell adhesion +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0007163 +name: establishment or maintenance of cell polarity +namespace: biological_process +alt_id: GO:0030012 +alt_id: GO:0030467 +def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] +synonym: "establishment and/or maintenance of cell polarity" RELATED [] +synonym: "establishment and/or maintenance of cell polarization" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0007164 +name: establishment of tissue polarity +namespace: biological_process +def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0007165 +name: signal transduction +namespace: biological_process +alt_id: GO:0023014 +alt_id: GO:0023015 +alt_id: GO:0023016 +alt_id: GO:0023033 +alt_id: GO:0023045 +def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] +comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_plant +synonym: "signal transduction by cis-phosphorylation" NARROW [] +synonym: "signal transduction by conformational transition" NARROW [] +synonym: "signal transduction by protein phosphorylation" NARROW [] +synonym: "signal transduction by trans-phosphorylation" NARROW [] +synonym: "signaling cascade" NARROW [] +synonym: "signaling pathway" RELATED [] +synonym: "signalling cascade" NARROW [] +synonym: "signalling pathway" RELATED [GOC:mah] +xref: Wikipedia:Signal_transduction +is_a: GO:0009987 ! cellular process +is_a: GO:0050794 ! regulation of cellular process +relationship: part_of GO:0007154 ! cell communication +relationship: part_of GO:0023052 ! signaling +relationship: part_of GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0007166 +name: cell surface receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] +subset: goslim_drosophila +synonym: "cell surface receptor linked signal transduction" EXACT [] +synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] +synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0007167 +name: enzyme linked receptor protein signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0815316194] +synonym: "enzyme linked receptor protein signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007168 +name: receptor guanylyl cyclase signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030] +synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007169 +name: transmembrane receptor protein tyrosine kinase signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] +synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007170 +name: obsolete transmembrane receptor protein tyrosine kinase ligand binding +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "transmembrane receptor protein tyrosine kinase ligand binding" EXACT [] +is_obsolete: true +consider: GO:0030971 + +[Term] +id: GO:0007171 +name: activation of transmembrane receptor protein tyrosine kinase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] +synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] +is_a: GO:0032147 ! activation of protein kinase activity +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0007172 +name: signal complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862] +synonym: "signal complex formation" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0007173 +name: epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb] +synonym: "EGF receptor signaling pathway" EXACT [] +synonym: "EGF receptor signalling pathway" EXACT [] +synonym: "EGFR signaling pathway" EXACT [] +synonym: "epidermal growth factor receptor signalling pathway" EXACT [] +synonym: "ERBB1 signaling pathway" EXACT [PR:000006933] +synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT [PR:000006933] +is_a: GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:0007174 +name: epidermal growth factor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587] +comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'. +synonym: "EGF breakdown" EXACT [GOC:bf] +synonym: "EGF catabolism" EXACT [GOC:bf] +synonym: "EGF receptor ligand processing" RELATED [GOC:bf] +synonym: "epidermal growth factor breakdown" EXACT [GOC:bf] +synonym: "epidermal growth factor catabolism" EXACT [GOC:bf] +synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf] +synonym: "intracellular EGF processing" RELATED [PMID:2985587] +synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723] +is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0007175 +name: negative regulation of epidermal growth factor-activated receptor activity +namespace: biological_process +alt_id: GO:0007177 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] +synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] +synonym: "EGF receptor downregulation" EXACT [] +synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] +synonym: "negative regulation of EGF receptor activity" EXACT [] +synonym: "negative regulation of EGFR activity" EXACT [] +synonym: "negative regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity +is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0007176 +name: regulation of epidermal growth factor-activated receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity." [GOC:dph, GOC:go_curators] +synonym: "regulation of EGF receptor activity" EXACT [] +synonym: "regulation of EGFR activity" EXACT [] +synonym: "regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity + +[Term] +id: GO:0007178 +name: transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] +synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007179 +name: transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] +synonym: "TGF-beta receptor signaling pathway" EXACT [] +synonym: "TGF-beta receptor signalling pathway" EXACT [] +synonym: "TGFbeta receptor signaling pathway" EXACT [] +synonym: "TGFbeta receptor signalling pathway" EXACT [] +synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: part_of GO:0071560 ! cellular response to transforming growth factor beta stimulus + +[Term] +id: GO:0007180 +name: obsolete transforming growth factor beta ligand binding to type II receptor +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function. +synonym: "TGF-beta ligand binding to type II receptor" EXACT [] +synonym: "TGFbeta ligand binding to type II receptor" EXACT [] +synonym: "transforming growth factor beta ligand binding to type II receptor" EXACT [] +is_obsolete: true +consider: GO:0005026 +consider: GO:0005160 +consider: GO:0050431 + +[Term] +id: GO:0007181 +name: transforming growth factor beta receptor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:R-HSA-170840, Wikipedia:TGF_beta_signaling_pathway] +synonym: "TGF-beta receptor complex assembly" EXACT [] +synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] +synonym: "TGFbeta receptor complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0007182 +name: common-partner SMAD protein phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782] +synonym: "co-SMAD protein phosphorylation" EXACT [GOC:rl] +synonym: "common mediator SMAD protein phosphorylation" EXACT [] +synonym: "common partner SMAD protein phosphorylation" EXACT [GOC:rl] +synonym: "common-mediator SMAD protein phosphorylation" EXACT [GOC:rl] +is_a: GO:0006468 ! protein phosphorylation +relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0007183 +name: SMAD protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] +synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0007185 +name: transmembrane receptor protein tyrosine phosphatase signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] +synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0007186 +name: G protein-coupled receptor signaling pathway +namespace: biological_process +alt_id: GO:0038042 +def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] +subset: goslim_drosophila +synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] +synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] +synonym: "G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "G-protein coupled receptor protein signal transduction" EXACT [] +synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] +synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] +synonym: "G-protein coupled receptor signalling pathway" EXACT [] +synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "GPCR signaling pathway" EXACT [] +synonym: "GPCR signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0007187 +name: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, GOC:signaling, ISBN:0815316194] +synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "G-protein signaling, coupled to cyclic nucleotide second messenger" EXACT [GOC:signaling] +synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] +synonym: "GPCR signaling pathway via cyclic nucleotide second messenger" EXACT [GOC:signaling] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007188 +name: adenylate cyclase-modulating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] +comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578. +synonym: "adenylate cyclase-modulating GPCR signaling pathway" EXACT [GOC:signaling] +synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G-protein signaling, coupled to cAMP nucleotide second messenger" EXACT [GOC:signaling] +synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] +synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] +synonym: "GPCR signaling pathway via cAMP second messenger" EXACT [GOC:signaling] +synonym: "GPCR signaling pathway via modulation of adenylate cyclase activity" EXACT [GOC:signaling] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007189 +name: adenylate cyclase-activating G protein-coupled receptor signaling pathway +namespace: biological_process +alt_id: GO:0010579 +alt_id: GO:0010580 +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] +comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway. +synonym: "activation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:bf] +synonym: "activation of adenylate cyclase activity involved in G-protein signaling" RELATED [GOC:signaling] +synonym: "adenylate cyclase-activating GPCR signaling pathway" EXACT [GOC:signaling] +synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] +synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] +synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] +synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] +synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] +synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] +synonym: "GPCR signaling pathway via activation of adenylate cyclase" EXACT [GOC:bf] +synonym: "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT [GOC:signaling] +synonym: "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] +synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED [GOC:mah] +synonym: "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007190 +name: activation of adenylate cyclase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] +synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] +synonym: "adenylate cyclase activator" RELATED [] +synonym: "adenylyl cyclase activation" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0007191 +name: adenylate cyclase-activating dopamine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling] +synonym: "activation of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" RELATED [GOC:mah] +synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] +synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] +is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0007192 +name: adenylate cyclase-activating serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] +synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb] +synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] +is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:0007210 ! serotonin receptor signaling pathway + +[Term] +id: GO:0007193 +name: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] +comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition. +synonym: "adenylate cyclase-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] +synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] +synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "GPCR signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] +is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007194 +name: negative regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase inhibitor" RELATED [] +synonym: "down regulation of adenylate cyclase activity" EXACT [] +synonym: "down-regulation of adenylate cyclase activity" EXACT [] +synonym: "downregulation of adenylate cyclase activity" EXACT [] +synonym: "inhibition of adenylate cyclase activity" NARROW [] +synonym: "negative regulation of adenylyl cyclase activity" EXACT [] +is_a: GO:0031280 ! negative regulation of cyclase activity +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0051350 ! negative regulation of lyase activity + +[Term] +id: GO:0007195 +name: adenylate cyclase-inhibiting dopamine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] +synonym: "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0007196 +name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway" EXACT [] +synonym: "inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] +synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] +synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway + +[Term] +id: GO:0007197 +name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] +synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" RELATED [GOC:mah] +synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway + +[Term] +id: GO:0007198 +name: adenylate cyclase-inhibiting serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] +synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" RELATED [] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway + +[Term] +id: GO:0007199 +name: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] +synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "G-protein signaling, coupled to cGMP nucleotide second messenger" EXACT [GOC:signaling] +synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] +synonym: "GPCR signaling pathway via activation of guanylate cyclase activity" EXACT [GOC:signaling] +synonym: "GPCR signaling pathway via cGMP second messenger" EXACT [GOC:signaling] +synonym: "guanylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling] +is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger + +[Term] +id: GO:0007200 +name: phospholipase C-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] +comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity. +synonym: "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:signaling] +synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:signaling] +synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb] +synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] +synonym: "phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:dph, GOC:tb] +synonym: "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] +synonym: "PLC-activating GPCR signaling pathway" EXACT [GOC:signaling] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007201 +name: obsolete G-protein dissociation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. +synonym: "G-protein dissociation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007202 +name: activation of phospholipase C activity +namespace: biological_process +def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] +comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. +synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010863 ! positive regulation of phospholipase C activity + +[Term] +id: GO:0007203 +name: obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because hydrolysis is a reaction, not a process. +synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" EXACT [] +is_obsolete: true +consider: GO:0004435 + +[Term] +id: GO:0007204 +name: positive regulation of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] +synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] +synonym: "cytosolic calcium ion concentration elevation" EXACT [] +synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] +synonym: "elevation of calcium ion concentration in cytosol" EXACT [] +synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] +synonym: "elevation of cytosolic calcium ion concentration" EXACT [] +is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0007205 +name: protein kinase C-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] +synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] +synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" RELATED [GOC:mah] +synonym: "protein kinase C-activating G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007206 +name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway" RELATED [GOC:bf] +synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" RELATED [GOC:mah] +synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] +synonym: "phospholipase C-activating G-protein coupled glutamate receptor signaling pathway" RELATED [] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway + +[Term] +id: GO:0007207 +name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] +synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] +synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] +synonym: "muscarinic receptor signaling pathway via activation of PLC" EXACT [GOC:signaling] +synonym: "phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway" EXACT [] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway + +[Term] +id: GO:0007208 +name: phospholipase C-activating serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "activation of phospholipase C activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" RELATED [GOC:mah] +synonym: "serotonin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway + +[Term] +id: GO:0007209 +name: phospholipase C-activating tachykinin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "activation of phospholipase C activity by tachykinin receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" RELATED [GOC:mah] +synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0007217 ! tachykinin receptor signaling pathway + +[Term] +id: GO:0007210 +name: serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "serotonin receptor signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:1903351 ! cellular response to dopamine + +[Term] +id: GO:0007211 +name: octopamine or tyramine signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] +synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah] +synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007212 +name: dopamine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah, PMID:21711983] +synonym: "dopamine receptor signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:1903351 ! cellular response to dopamine + +[Term] +id: GO:0007213 +name: G protein-coupled acetylcholine receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] +synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] +synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] +synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0095500 ! acetylcholine receptor signaling pathway + +[Term] +id: GO:0007214 +name: gamma-aminobutyric acid signaling pathway +namespace: biological_process +def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] +synonym: "4-aminobutanoate signaling pathway" EXACT [] +synonym: "4-aminobutanoate signalling pathway" EXACT [] +synonym: "4-aminobutyrate signaling pathway" EXACT [] +synonym: "4-aminobutyrate signalling pathway" EXACT [] +synonym: "GABA signaling pathway" EXACT [] +synonym: "GABA signalling pathway" EXACT [] +synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0007215 +name: glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] +synonym: "glutamate signaling pathway" EXACT [GOC:bf] +synonym: "glutamate signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007216 +name: G protein-coupled glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] +synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] +synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] +synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0007215 ! glutamate receptor signaling pathway + +[Term] +id: GO:0007217 +name: tachykinin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] +synonym: "tachykinin signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007218 +name: neuropeptide signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] +synonym: "neuropeptide signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0007219 +name: Notch signaling pathway +namespace: biological_process +alt_id: GO:0030179 +def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] +synonym: "N signaling pathway" EXACT [] +synonym: "N signalling pathway" EXACT [] +synonym: "Notch receptor signaling pathway" EXACT [] +synonym: "Notch receptor signalling pathway" EXACT [] +synonym: "Notch signalling pathway" EXACT [] +synonym: "Notch-receptor signaling pathway" EXACT [] +synonym: "Notch-receptor signalling pathway" EXACT [] +xref: Wikipedia:Notch_signaling_pathway +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007220 +name: Notch receptor processing +namespace: biological_process +def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] +synonym: "N receptor processing" EXACT [] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0007221 +name: positive regulation of transcription of Notch receptor target +namespace: biological_process +def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] +synonym: "N receptor target transcription factor activation" RELATED [] +synonym: "Notch receptor target transcription factor activation" RELATED [] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0007223 +name: Wnt signaling pathway, calcium modulating pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] +synonym: "frizzled-2 signaling pathway" NARROW [] +synonym: "frizzled-2 signalling pathway" NARROW [] +synonym: "non-canonical Wnt signaling pathway" RELATED [] +synonym: "Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] +synonym: "Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] +is_a: GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:0007224 +name: smoothened signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] +synonym: "hedgehog signaling pathway" EXACT [] +synonym: "hh signaling pathway" NARROW [] +synonym: "hh signalling pathway" NARROW [] +synonym: "Shh signaling pathway" RELATED [GOC:dph] +synonym: "smoothened signalling pathway" EXACT [] +synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph] +xref: Wikipedia:Hedgehog_signaling_pathway +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007225 +name: patched ligand maturation +namespace: biological_process +def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936] +synonym: "Hedgehog protein processing" NARROW [] +synonym: "hh protein processing" EXACT [] +synonym: "patched ligand processing" RELATED [] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0007227 +name: signal transduction downstream of smoothened +namespace: biological_process +def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] +is_a: GO:0035556 ! intracellular signal transduction +relationship: part_of GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0007228 +name: positive regulation of hh target transcription factor activity +namespace: biological_process +def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] +synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd] +is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity +relationship: part_of GO:0007227 ! signal transduction downstream of smoothened + +[Term] +id: GO:0007229 +name: integrin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] +synonym: "integrin-mediated signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0007230 +name: obsolete calcium-o-sensing receptor pathway +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it does not make sense. +synonym: "calcium-o-sensing receptor pathway" EXACT [] +is_obsolete: true +consider: GO:0019722 + +[Term] +id: GO:0007231 +name: osmosensory signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] +synonym: "osmolarity sensing" EXACT [] +synonym: "osmolarity sensing signaling pathway" EXACT [] +synonym: "osmolarity sensing signalling pathway" EXACT [] +synonym: "osmosensory signal transduction" EXACT [GOC:signaling] +synonym: "osmosensory signalling pathway" EXACT [] +synonym: "signal transduction during osmotic stress" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction +is_a: GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0007232 +name: osmosensory signaling pathway via Sho1 osmosensor +namespace: biological_process +def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] +synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] +synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] +is_a: GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0007234 +name: osmosensory signaling via phosphorelay pathway +namespace: biological_process +def: "A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system." [PMID:9843501] +synonym: "osmolarity sensing via two-component system" EXACT [] +synonym: "osmolarity signaling pathway via two-component system" EXACT [] +synonym: "osmolarity signalling pathway via two-component system" EXACT [] +synonym: "osmosensory signaling pathway via two-component system" NARROW [] +synonym: "osmosensory signalling pathway via two-component system" EXACT [] +synonym: "signal transduction during osmotic stress via two-component system" EXACT [] +is_a: GO:0000160 ! phosphorelay signal transduction system +is_a: GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0007235 +name: obsolete activation of Ypd1 protein +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "activation of Ypd1 protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007236 +name: obsolete activation of Ssk1 protein +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "activation of Ssk1 protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007237 +name: obsolete activation of Ssk2/Ssk22 proteins +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "activation of Ssk2/Ssk22 proteins" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007238 +name: obsolete activation of Pbs2 +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "activation of Pbs2" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007239 +name: obsolete activation of Hog1 +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "activation of Hog1" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007240 +name: obsolete nuclear translocation of Hog1 +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "nuclear translocation of Hog1" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007241 +name: obsolete inactivation of Hog1 +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains gene product and species specific information. +synonym: "inactivation of Hog1" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007244 +name: obsolete MAPKKK cascade (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "MAPKKK cascade (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007245 +name: obsolete activation of MAPKKK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKKK (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007246 +name: obsolete activation of MAPKK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKK (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007247 +name: obsolete activation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPK (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +consider: GO:0000750 + +[Term] +id: GO:0007248 +name: obsolete nuclear translocation of MAPK (mating sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "nuclear translocation of MAPK (mating sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0007249 +name: I-kappaB kinase/NF-kappaB signaling +namespace: biological_process +def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560] +synonym: "activation of the inhibitor of kappa kinase" RELATED [] +synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf] +synonym: "I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling] +synonym: "NF-kappaB cascade" BROAD [] +synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0007250 +name: activation of NF-kappaB-inducing kinase activity +namespace: biological_process +def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] +synonym: "activation of NIK activity" EXACT [GOC:bf] +synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD [] +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling + +[Term] +id: GO:0007251 +name: obsolete activation of the inhibitor of kappa kinase +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its meaning was unclear. +synonym: "activation of the inhibitor of kappa kinase" EXACT [] +is_obsolete: true +consider: GO:0007249 + +[Term] +id: GO:0007252 +name: I-kappaB phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468] +synonym: "IkappaB phosphorylation" EXACT [GOC:bf] +synonym: "IKB phosphorylation" EXACT [GOC:bf] +synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf] +synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf] +is_a: GO:0006468 ! protein phosphorylation +relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling + +[Term] +id: GO:0007253 +name: cytoplasmic sequestering of NF-kappaB +namespace: biological_process +def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] +synonym: "cytoplasmic NF-kappaB retention" EXACT [] +synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] +synonym: "cytoplasmic NF-kappaB storage" EXACT [] +synonym: "cytoplasmic retention of NF-kappaB" EXACT [] +synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] +synonym: "cytoplasmic storage of NF-kappaB" EXACT [] +synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032088 ! negative regulation of NF-kappaB transcription factor activity +is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor + +[Term] +id: GO:0007254 +name: JNK cascade +namespace: biological_process +def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] +synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974] +synonym: "JNK1 cascade" NARROW [GOC:add] +synonym: "JNK2 cascade" NARROW [GOC:add] +synonym: "JNK3 cascade" NARROW [GOC:add] +synonym: "MAPK10 cascade" NARROW [GOC:add] +synonym: "MAPK8 cascade" NARROW [GOC:add] +synonym: "MAPK9 cascade" NARROW [GOC:add] +synonym: "SAPK cascade" BROAD [] +synonym: "stress-activated protein kinase cascade" BROAD [] +is_a: GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0007256 +name: obsolete activation of JNKK activity +namespace: biological_process +def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of JUN kinase kinase activity" EXACT [] +synonym: "positive regulation of JUNKK activity" BROAD [] +is_obsolete: true +consider: GO:0043539 +consider: GO:0046328 + +[Term] +id: GO:0007257 +name: obsolete activation of JUN kinase activity +namespace: biological_process +def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf] +synonym: "activation of SAPK activity" BROAD [] +is_obsolete: true +consider: GO:0007254 +consider: GO:0043539 + +[Term] +id: GO:0007258 +name: JUN phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] +is_a: GO:0006468 ! protein phosphorylation +relationship: part_of GO:0007254 ! JNK cascade + +[Term] +id: GO:0007259 +name: receptor signaling pathway via JAK-STAT +namespace: biological_process +def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] +synonym: "JAK-STAT cascade" NARROW [] +synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling] +xref: Wikipedia:JAK-STAT_signaling_pathway +is_a: GO:0097696 ! receptor signaling pathway via STAT + +[Term] +id: GO:0007260 +name: tyrosine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:0042502 +alt_id: GO:0042503 +alt_id: GO:0042504 +alt_id: GO:0042505 +alt_id: GO:0042506 +alt_id: GO:0042507 +alt_id: GO:0042508 +def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] +synonym: "tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "tyrosine phosphorylation of Stat7 protein" NARROW [] +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +relationship: part_of GO:0007259 ! receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0007261 +name: obsolete JAK-induced STAT protein dimerization +namespace: biological_process +def: "OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] +comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms. +synonym: "JAK-induced STAT protein dimerization" EXACT [] +is_obsolete: true +consider: GO:0007260 +consider: GO:0046983 + +[Term] +id: GO:0007263 +name: nitric oxide mediated signal transduction +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190] +synonym: "nitric oxide signaling" EXACT [GOC:bf] +synonym: "nitric oxide-mediated signal transduction" EXACT [] +synonym: "NO mediated signal transduction" EXACT [] +synonym: "NO-mediated signal transduction" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0007264 +name: small GTPase mediated signal transduction +namespace: biological_process +def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] +synonym: "small GTPase-mediated signal transduction" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0007265 +name: Ras protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Ras mediated signal transduction" EXACT [] +is_a: GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0007266 +name: Rho protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Rho mediated signal transduction" EXACT [] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0007267 +name: cell-cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] +subset: goslim_chembl +subset: goslim_plant +synonym: "cell-cell signalling" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0023052 ! signaling + +[Term] +id: GO:0007268 +name: chemical synaptic transmission +namespace: biological_process +def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] +subset: goslim_synapse +synonym: "neurotransmission" RELATED [GOC:dph] +synonym: "signal transmission across a synapse" BROAD [] +synonym: "synaptic transmission" BROAD [] +xref: Wikipedia:Neurotransmission +is_a: GO:0098916 ! anterograde trans-synaptic signaling + +[Term] +id: GO:0007269 +name: neurotransmitter secretion +namespace: biological_process +alt_id: GO:0010554 +def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [GOC:dph] +comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. +subset: goslim_synapse +synonym: "neurotransmitter release" EXACT [] +synonym: "neurotransmitter secretory pathway" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099643 ! signal release from synapse +relationship: part_of GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0007270 +name: neuron-neuron synaptic transmission +namespace: biological_process +def: "The process of synaptic transmission from a neuron to another neuron across a synapse." [GOC:add, GOC:dos, GOC:jl, MeSH:D009435] +synonym: "nerve-nerve synaptic transmission" RELATED [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0007271 +name: synaptic transmission, cholinergic +namespace: biological_process +def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] +synonym: "cholinergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0007272 +name: ensheathment of neurons +namespace: biological_process +def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] +synonym: "ionic insulation of neurons by glial cells" RELATED [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007273 +name: obsolete regulation of synapse +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term string made no sense. +synonym: "regulation of synapse" EXACT [] +is_obsolete: true +consider: GO:0007268 + +[Term] +id: GO:0007274 +name: neuromuscular synaptic transmission +namespace: biological_process +def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0007275 +name: multicellular organism development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] +comment: Note that this term was 'developmental process'. +subset: gocheck_do_not_annotate +subset: goslim_chembl +subset: goslim_plant +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0007276 +name: gamete generation +namespace: biological_process +alt_id: GO:0009552 +def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] +synonym: "gametogenesis" RELATED [] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0007277 +name: pole cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0007278 +name: pole cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007277 ! pole cell development + +[Term] +id: GO:0007279 +name: pole cell formation +namespace: biological_process +def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] +comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0007277 ! pole cell development + +[Term] +id: GO:0007280 +name: pole cell migration +namespace: biological_process +def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] +comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. +is_a: GO:0008354 ! germ cell migration + +[Term] +id: GO:0007281 +name: germ cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] +synonym: "germ-cell development" EXACT [] +synonym: "primordial germ cell development" NARROW [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0007282 +name: cystoblast division +namespace: biological_process +def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446] +synonym: "cystoblast cell division" EXACT [] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0007283 +name: spermatogenesis +namespace: biological_process +def: "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa." [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] +synonym: "generation of spermatozoa" EXACT systematic_synonym [] +xref: Wikipedia:Spermatogenesis +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048232 ! male gamete generation + +[Term] +id: GO:0007284 +name: spermatogonial cell division +namespace: biological_process +def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] +comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. +synonym: "spermatogonium division" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051301 ! cell division +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0007285 +name: primary spermatocyte growth +namespace: biological_process +def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0007286 +name: spermatid development +namespace: biological_process +def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] +synonym: "spermatid cell development" EXACT [] +synonym: "spermiogenesis" EXACT [] +xref: Wikipedia:Spermiogenesis +is_a: GO:0007281 ! germ cell development +relationship: part_of GO:0048515 ! spermatid differentiation + +[Term] +id: GO:0007287 +name: Nebenkern assembly +namespace: biological_process +def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238, PMID:9550716] +comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. +synonym: "Nebenkern formation" RELATED [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007288 +name: sperm axoneme assembly +namespace: biological_process +def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0035082 ! axoneme assembly +relationship: part_of GO:0120316 ! sperm flagellum assembly + +[Term] +id: GO:0007289 +name: spermatid nucleus differentiation +namespace: biological_process +def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] +comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. +synonym: "spermatid nuclear differentiation" EXACT [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007290 +name: spermatid nucleus elongation +namespace: biological_process +def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "spermatid nuclear elongation" EXACT [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0007291 +name: sperm individualization +namespace: biological_process +def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0007292 +name: female gamete generation +namespace: biological_process +def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] +is_a: GO:0007276 ! gamete generation + +[Term] +id: GO:0007293 +name: germarium-derived egg chamber formation +namespace: biological_process +def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007294 +name: germarium-derived oocyte fate determination +namespace: biological_process +alt_id: GO:0016350 +def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "maintenance of oocyte identity" RELATED [] +synonym: "oocyte cell fate determination" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030716 ! oocyte fate determination +relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation + +[Term] +id: GO:0007295 +name: growth of a germarium-derived egg chamber +namespace: biological_process +def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "egg chamber growth" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007296 +name: vitellogenesis +namespace: biological_process +def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] +synonym: "yolk formation" EXACT [] +synonym: "yolk production" EXACT systematic_synonym [] +xref: Wikipedia:Vitellogenesis +is_a: GO:0007028 ! cytoplasm organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0007297 +name: ovarian follicle cell migration +namespace: biological_process +def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] +synonym: "follicle cell migration" BROAD [] +is_a: GO:0010631 ! epithelial cell migration +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007298 +name: border follicle cell migration +namespace: biological_process +def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] +synonym: "border cell migration" BROAD [] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0007299 +name: ovarian follicle cell-cell adhesion +namespace: biological_process +def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] +synonym: "follicle cell adhesion" BROAD [] +synonym: "ovarian follicle cell adhesion" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0090136 ! epithelial cell-cell adhesion +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007300 +name: ovarian nurse cell to oocyte transport +namespace: biological_process +def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "nurse cell to oocyte transport" BROAD [] +is_a: GO:0006810 ! transport +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0007301 +name: female germline ring canal formation +namespace: biological_process +def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] +synonym: "nurse cell ring canal formation" NARROW [] +synonym: "ovarian ring canal formation" NARROW [] +is_a: GO:0030725 ! germline ring canal formation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0007302 +name: nurse cell nucleus anchoring +namespace: biological_process +def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] +is_a: GO:0051647 ! nucleus localization + +[Term] +id: GO:0007303 +name: cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0007304 +name: chorion-containing eggshell formation +namespace: biological_process +def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +synonym: "eggshell formation" BROAD [] +is_a: GO:0030703 ! eggshell formation +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0007305 +name: vitelline membrane formation involved in chorion-containing eggshell formation +namespace: biological_process +def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb] +is_a: GO:0030704 ! vitelline membrane formation +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0007306 +name: eggshell chorion assembly +namespace: biological_process +def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb] +synonym: "insect chorion formation" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045229 ! external encapsulating structure organization +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0007307 +name: eggshell chorion gene amplification +namespace: biological_process +def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] +is_a: GO:0006277 ! DNA amplification +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007306 ! eggshell chorion assembly + +[Term] +id: GO:0007308 +name: oocyte construction +namespace: biological_process +alt_id: GO:0048110 +def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] +synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0007309 +name: oocyte axis specification +namespace: biological_process +alt_id: GO:0048111 +def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte axis determination" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0007308 ! oocyte construction + +[Term] +id: GO:0007310 +name: oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0008072 +alt_id: GO:0048123 +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah] +synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah] +is_a: GO:0007309 ! oocyte axis specification +is_a: GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0007311 +name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded +namespace: biological_process +alt_id: GO:0048124 +def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] +synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] +synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] +is_a: GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007312 +name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0008102 +alt_id: GO:0030722 +alt_id: GO:0048126 +alt_id: GO:0048128 +def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] +synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD [] +synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" RELATED [GOC:mah] +synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] +synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" RELATED [GOC:mah] +synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification" RELATED [] +synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" RELATED [GOC:mah] +synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD [] +synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD [] +synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD [] +synonym: "oocyte axis determination, establishment of position of nucleus" BROAD [] +synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] +synonym: "oocyte axis determination, positioning of nucleus" BROAD [] +synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] +synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007313 +name: maternal specification of dorsal/ventral axis, oocyte, soma encoded +namespace: biological_process +alt_id: GO:0048125 +def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] +synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah] +synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah] +is_a: GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0007314 +name: oocyte anterior/posterior axis specification +namespace: biological_process +alt_id: GO:0048112 +def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] +synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007309 ! oocyte axis specification +is_a: GO:0009948 ! anterior/posterior axis specification +relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007315 +name: pole plasm assembly +namespace: biological_process +alt_id: GO:0048113 +def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] +is_a: GO:0007028 ! cytoplasm organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification + +[Term] +id: GO:0007316 +name: pole plasm RNA localization +namespace: biological_process +alt_id: GO:0048116 +def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] +synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] +synonym: "oocyte pole plasm RNA localization" EXACT [] +synonym: "pole plasm RNA localisation" EXACT [GOC:mah] +is_a: GO:0006403 ! RNA localization +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0007317 +name: regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] +synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] +is_a: GO:1904580 ! regulation of intracellular mRNA localization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0007318 +name: pole plasm protein localization +namespace: biological_process +alt_id: GO:0048115 +def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] +synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] +synonym: "oocyte pole plasm protein localization" EXACT [] +synonym: "pole plasm protein localisation" EXACT [GOC:mah] +is_a: GO:0008104 ! protein localization +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0007319 +name: negative regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] +synonym: "down regulation of oskar mRNA translation" EXACT [] +synonym: "down-regulation of oskar mRNA translation" EXACT [] +synonym: "downregulation of oskar mRNA translation" EXACT [] +synonym: "inhibition of oskar mRNA translation" NARROW [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0046011 ! regulation of oskar mRNA translation + +[Term] +id: GO:0007320 +name: insemination +namespace: biological_process +def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] +xref: Wikipedia:Insemination +is_a: GO:0044703 ! multi-organism reproductive process +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007620 ! copulation + +[Term] +id: GO:0007321 +name: sperm displacement +namespace: biological_process +def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0007323 +name: peptide pheromone maturation +namespace: biological_process +alt_id: GO:0007324 +alt_id: GO:0007326 +alt_id: GO:0046613 +def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] +synonym: "pheromone processing" EXACT [] +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0007329 +name: positive regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] +synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +is_a: GO:0009371 ! positive regulation of transcription by pheromones +is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus + +[Term] +id: GO:0007336 +name: obsolete bilateral process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it gives no indication of what it refers to. +synonym: "bilateral process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007337 +name: obsolete unilateral process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it gives no indication of what it refers to. +synonym: "unilateral process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007338 +name: single fertilization +namespace: biological_process +def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] +synonym: "zygote biosynthesis" RELATED [] +synonym: "zygote formation" RELATED [] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0007339 +name: binding of sperm to zona pellucida +namespace: biological_process +def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] +synonym: "ZPG binding" RELATED [] +is_a: GO:0035036 ! sperm-egg recognition + +[Term] +id: GO:0007340 +name: acrosome reaction +namespace: biological_process +def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida." [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029] +comment: If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss. +xref: Wikipedia:Acrosome_reaction +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007341 +name: penetration of zona pellucida +namespace: biological_process +def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007342 +name: fusion of sperm to egg plasma membrane involved in single fertilization +namespace: biological_process +def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +synonym: "sperm-oocyte fusion" NARROW [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007343 +name: egg activation +namespace: biological_process +def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] +xref: Wikipedia:Egg_activation +is_a: GO:0001775 ! cell activation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007344 +name: pronuclear fusion +namespace: biological_process +def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] +is_a: GO:0000741 ! karyogamy +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0007345 +name: obsolete embryogenesis and morphogenesis +namespace: biological_process +def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] +comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. +synonym: "embryogenesis and morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0009653 +consider: GO:0009790 + +[Term] +id: GO:0007346 +name: regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "mitotic cell cycle modulation" EXACT [] +synonym: "mitotic cell cycle regulation" EXACT [] +synonym: "mitotic cell cycle regulator" RELATED [] +synonym: "modulation of mitotic cell cycle progression" EXACT [] +synonym: "regulation of mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +relationship: regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0007347 +name: regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] +synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] +synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] +synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0007348 +name: regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] +synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "syncytial blastoderm cell cycle modulation" EXACT [] +synonym: "syncytial blastoderm cell cycle regulation" EXACT [] +synonym: "syncytial blastoderm cell cycle regulator" RELATED [] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0022402 ! cell cycle process +relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0007349 +name: cellularization +namespace: biological_process +alt_id: GO:0009796 +def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007350 +name: blastoderm segmentation +namespace: biological_process +def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009880 ! embryonic pattern specification +is_a: GO:0035282 ! segmentation + +[Term] +id: GO:0007351 +name: tripartite regional subdivision +namespace: biological_process +def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0007352 +name: zygotic specification of dorsal/ventral axis +namespace: biological_process +def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] +synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah] +synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph] +synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0007353 +name: obsolete ventral/lateral system +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "ventral/lateral system" EXACT [] +is_obsolete: true +consider: GO:0009880 + +[Term] +id: GO:0007354 +name: zygotic determination of anterior/posterior axis, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0008595 ! anterior/posterior axis specification, embryo + +[Term] +id: GO:0007355 +name: anterior region determination +namespace: biological_process +def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007356 +name: thorax and anterior abdomen determination +namespace: biological_process +def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007357 +name: obsolete positive regulation of central gap gene transcription +namespace: biological_process +def: "OBSOLETE. The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [ISBN:0879694238] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of central gap gene" BROAD [] +synonym: "activation of central gap gene transcription" NARROW [] +synonym: "stimulation of central gap gene transcription" NARROW [] +synonym: "up regulation of central gap gene transcription" EXACT [] +synonym: "up-regulation of central gap gene transcription" EXACT [] +synonym: "upregulation of central gap gene transcription" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007358 +name: obsolete establishment of central gap gene boundaries +namespace: biological_process +def: "OBSOLETE. Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes. +is_obsolete: true + +[Term] +id: GO:0007359 +name: posterior abdomen determination +namespace: biological_process +def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +comment: Note that this process is exemplified in insects by the actions of the knirps gene product. +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007360 +name: obsolete positive regulation of posterior gap gene transcription +namespace: biological_process +def: "OBSOLETE. The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [ISBN:0879694238] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of posterior gap gene" BROAD [] +synonym: "activation of posterior gap gene transcription" NARROW [] +synonym: "knirps activation" NARROW [] +synonym: "stimulation of posterior gap gene transcription" NARROW [] +synonym: "up regulation of posterior gap gene transcription" EXACT [] +synonym: "up-regulation of posterior gap gene transcription" EXACT [] +synonym: "upregulation of posterior gap gene transcription" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007361 +name: obsolete establishment of posterior gap gene boundaries +namespace: biological_process +def: "OBSOLETE. Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes. +is_obsolete: true + +[Term] +id: GO:0007362 +name: terminal region determination +namespace: biological_process +def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0009880 ! embryonic pattern specification +relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo + +[Term] +id: GO:0007363 +name: obsolete positive regulation of terminal gap gene transcription +namespace: biological_process +def: "OBSOLETE. The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [ISBN:0879694238] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of terminal gap gene" BROAD [] +synonym: "activation of terminal gap gene transcription" NARROW [] +synonym: "stimulation of terminal gap gene transcription" NARROW [] +synonym: "up regulation of terminal gap gene transcription" EXACT [] +synonym: "up-regulation of terminal gap gene transcription" EXACT [] +synonym: "upregulation of terminal gap gene transcription" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007364 +name: obsolete establishment of terminal gap gene boundary +namespace: biological_process +def: "OBSOLETE. Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +comment: This term has been obsoleted because it represents a transcriptional feedback loop covered by other processes. +is_obsolete: true + +[Term] +id: GO:0007365 +name: periodic partitioning +namespace: biological_process +def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] +comment: Note that examples of periodic partitions are tagmata, segments or parasegments. +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0007366 +name: periodic partitioning by pair rule gene +namespace: biological_process +def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] +is_a: GO:0007365 ! periodic partitioning +is_a: GO:0009952 ! anterior/posterior pattern specification + +[Term] +id: GO:0007367 +name: segment polarity determination +namespace: biological_process +def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] +is_a: GO:0007365 ! periodic partitioning + +[Term] +id: GO:0007368 +name: determination of left/right symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] +synonym: "determination of left/right asymmetry" EXACT [GOC:dph] +is_a: GO:0009855 ! determination of bilateral symmetry + +[Term] +id: GO:0007369 +name: gastrulation +namespace: biological_process +def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] +subset: goslim_drosophila +xref: Wikipedia:Gastrulation +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0007370 +name: ventral furrow formation +namespace: biological_process +def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:0879694238] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007371 +name: ventral midline determination +namespace: biological_process +alt_id: GO:0007372 +alt_id: GO:0007373 +def: "The regionalization process in which the area where the ventral midline will form is specified." [GOC:bf, GOC:isa_complete, GOC:vk] +synonym: "determination of anterior border of ventral midline" NARROW [] +synonym: "determination of posterior border of ventral midline" NARROW [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007418 ! ventral midline development + +[Term] +id: GO:0007374 +name: posterior midgut invagination +namespace: biological_process +def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:0879694238] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007375 +name: anterior midgut invagination +namespace: biological_process +def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:0879694238] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007376 +name: cephalic furrow formation +namespace: biological_process +def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:0879694238] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007377 +name: germ-band extension +namespace: biological_process +def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:0879694238] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007378 +name: amnioserosa formation +namespace: biological_process +def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:0879694238] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0010004 ! gastrulation involving germ band extension + +[Term] +id: GO:0007379 +name: segment specification +namespace: biological_process +def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0035282 ! segmentation + +[Term] +id: GO:0007380 +name: specification of segmental identity, head +namespace: biological_process +def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0007379 ! segment specification +relationship: part_of GO:0035287 ! head segmentation + +[Term] +id: GO:0007381 +name: specification of segmental identity, labial segment +namespace: biological_process +def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0007382 +name: specification of segmental identity, maxillary segment +namespace: biological_process +def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0007383 +name: specification of segmental identity, antennal segment +namespace: biological_process +def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035288 ! anterior head segmentation + +[Term] +id: GO:0007384 +name: specification of segmental identity, thorax +namespace: biological_process +def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0035292 ! specification of segmental identity, trunk + +[Term] +id: GO:0007385 +name: specification of segmental identity, abdomen +namespace: biological_process +def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +is_a: GO:0035292 ! specification of segmental identity, trunk + +[Term] +id: GO:0007386 +name: compartment pattern specification +namespace: biological_process +def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "compartment specification" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern specification + +[Term] +id: GO:0007387 +name: anterior compartment pattern formation +namespace: biological_process +def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "anterior compartment pattern specification" RELATED [GOC:dph] +is_a: GO:0007386 ! compartment pattern specification + +[Term] +id: GO:0007388 +name: posterior compartment specification +namespace: biological_process +def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0007386 ! compartment pattern specification + +[Term] +id: GO:0007389 +name: pattern specification process +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] +subset: goslim_drosophila +synonym: "pattern biosynthesis" RELATED [] +synonym: "pattern formation" RELATED [] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007390 +name: germ-band shortening +namespace: biological_process +def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] +synonym: "germ-band retraction" EXACT [] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0007391 +name: dorsal closure +namespace: biological_process +def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0007392 +name: initiation of dorsal closure +namespace: biological_process +def: "Events that occur at the start of dorsal closure." [GOC:bf] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007393 +name: dorsal closure, leading edge cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] +is_a: GO:0035028 ! leading edge cell fate determination +relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment + +[Term] +id: GO:0007394 +name: dorsal closure, elongation of leading edge cells +namespace: biological_process +def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] +is_a: GO:0009826 ! unidimensional cell growth +is_a: GO:0016476 ! regulation of embryonic cell shape +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007392 ! initiation of dorsal closure + +[Term] +id: GO:0007395 +name: dorsal closure, spreading of leading edge cells +namespace: biological_process +def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007396 +name: suture of dorsal opening +namespace: biological_process +def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0007397 +name: obsolete histogenesis and organogenesis +namespace: biological_process +def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "histogenesis and organogenesis" EXACT [] +is_obsolete: true +consider: GO:0009887 +consider: GO:0009888 + +[Term] +id: GO:0007398 +name: ectoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007399 +name: nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] +subset: goslim_drosophila +synonym: "pan-neural process" RELATED [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0007400 +name: neuroblast fate determination +namespace: biological_process +alt_id: GO:0007408 +alt_id: GO:0043347 +alt_id: GO:0043348 +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] +synonym: "neuroblast cell fate determination" EXACT [] +synonym: "neuroblast identity determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0014017 ! neuroblast fate commitment + +[Term] +id: GO:0007401 +name: obsolete pan-neural process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because its meaning is ambiguous. +synonym: "pan-neural process" EXACT [] +is_obsolete: true +consider: GO:0007399 +consider: GO:0050877 + +[Term] +id: GO:0007402 +name: ganglion mother cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0001709 ! cell fate determination + +[Term] +id: GO:0007403 +name: glial cell fate determination +namespace: biological_process +alt_id: GO:0043361 +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0021781 ! glial cell fate commitment + +[Term] +id: GO:0007405 +name: neuroblast proliferation +namespace: biological_process +alt_id: GO:0043349 +alt_id: GO:0043350 +def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0007406 +name: negative regulation of neuroblast proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] +synonym: "down regulation of neuroblast proliferation" EXACT [] +synonym: "down-regulation of neuroblast proliferation" EXACT [] +synonym: "downregulation of neuroblast proliferation" EXACT [] +synonym: "inhibition of neuroblast proliferation" NARROW [] +synonym: "suppression of neuroblast proliferation" EXACT [] +is_a: GO:0050768 ! negative regulation of neurogenesis +is_a: GO:1902692 ! regulation of neuroblast proliferation +is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0007407 +name: neuroblast activation +namespace: biological_process +alt_id: GO:0043351 +alt_id: GO:0043352 +def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0007409 +name: axonogenesis +namespace: biological_process +alt_id: GO:0007410 +def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] +comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). +synonym: "axon growth" NARROW [] +synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] +synonym: "neuron long process generation" EXACT systematic_synonym [] +is_a: GO:0048812 ! neuron projection morphogenesis +relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation +relationship: part_of GO:0061564 ! axon development + +[Term] +id: GO:0007411 +name: axon guidance +namespace: biological_process +alt_id: GO:0008040 +def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] +synonym: "axon chemotaxis" RELATED [] +synonym: "axon growth cone guidance" NARROW [] +synonym: "axon pathfinding" EXACT [GOC:mah] +xref: Wikipedia:Axon_guidance +is_a: GO:0097485 ! neuron projection guidance +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007412 +name: axon target recognition +namespace: biological_process +def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0007413 +name: axonal fasciculation +namespace: biological_process +def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] +synonym: "fasciculation of neuron" RELATED [] +is_a: GO:0008038 ! neuron recognition +is_a: GO:0106030 ! neuron projection fasciculation +relationship: part_of GO:0061564 ! axon development + +[Term] +id: GO:0007414 +name: axonal defasciculation +namespace: biological_process +def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] +synonym: "defasciculation of neuron" RELATED [] +is_a: GO:0008038 ! neuron recognition +relationship: part_of GO:0061564 ! axon development + +[Term] +id: GO:0007415 +name: defasciculation of motor neuron axon +namespace: biological_process +def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] +is_a: GO:0007414 ! axonal defasciculation + +[Term] +id: GO:0007416 +name: synapse assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] +subset: goslim_synapse +synonym: "synapse biogenesis" EXACT [GOC:mah] +synonym: "synaptogenesis" EXACT [GOC:mah] +xref: Wikipedia:Synaptogenesis +is_a: GO:0034329 ! cell junction assembly +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007417 +name: central nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] +synonym: "CNS development" EXACT [] +xref: Wikipedia:Neural_development +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007418 +name: ventral midline development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0007419 +name: ventral cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0007420 +name: brain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0007417 ! central nervous system development +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0007421 +name: stomatogastric nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007422 +name: peripheral nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0007423 +name: sensory organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] +subset: goslim_drosophila +synonym: "sense organ development" EXACT [GOC:dph] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0007424 +name: open tracheal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] +comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. +is_a: GO:0060541 ! respiratory system development + +[Term] +id: GO:0007425 +name: epithelial cell fate determination, open tracheal system +namespace: biological_process +alt_id: GO:0046846 +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] +synonym: "tracheal cell fate determination" BROAD [] +synonym: "tracheal epithelial cell fate determination" EXACT [] +synonym: "tracheal placode cell fate determination" RELATED [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007426 +name: tracheal outgrowth, open tracheal system +namespace: biological_process +def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007427 +name: epithelial cell migration, open tracheal system +namespace: biological_process +def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "tracheal cell migration" BROAD [] +synonym: "tracheal epithelial cell migration" RELATED [] +is_a: GO:0010631 ! epithelial cell migration +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0007428 +name: primary branching, open tracheal system +namespace: biological_process +def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090] +synonym: "primary tracheal branching" EXACT [] +is_a: GO:0060446 ! branching involved in open tracheal system development + +[Term] +id: GO:0007429 +name: secondary branching, open tracheal system +namespace: biological_process +def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090] +synonym: "secondary tracheal branching" EXACT [] +is_a: GO:0060446 ! branching involved in open tracheal system development + +[Term] +id: GO:0007430 +name: terminal branching, open tracheal system +namespace: biological_process +def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:29844090] +synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT [] +is_a: GO:0060446 ! branching involved in open tracheal system development + +[Term] +id: GO:0007431 +name: salivary gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] +subset: goslim_drosophila +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035272 ! exocrine system development + +[Term] +id: GO:0007432 +name: salivary gland boundary specification +namespace: biological_process +def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] +synonym: "salivary gland determination" EXACT [] +is_a: GO:0010160 ! formation of animal organ boundary +relationship: part_of GO:0007431 ! salivary gland development + +[Term] +id: GO:0007433 +name: larval salivary gland boundary specification +namespace: biological_process +def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] +synonym: "larval salivary gland determination" BROAD [GOC:tb] +is_a: GO:0007432 ! salivary gland boundary specification +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007434 +name: adult salivary gland boundary specification +namespace: biological_process +def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] +synonym: "larval salivary gland determination" BROAD [GOC:tb] +is_a: GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0007435 +name: salivary gland morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0007431 ! salivary gland development + +[Term] +id: GO:0007436 +name: larval salivary gland morphogenesis +namespace: biological_process +def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] +is_a: GO:0007435 ! salivary gland morphogenesis +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007437 +name: adult salivary gland morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators] +is_a: GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0007438 +name: oenocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0001742 ! oenocyte differentiation + +[Term] +id: GO:0007439 +name: ectodermal digestive tract development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] +synonym: "ectodermal gut development" RELATED [GOC:dph] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0007440 +name: foregut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0007441 +name: anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis + +[Term] +id: GO:0007442 +name: hindgut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048546 ! digestive tract morphogenesis +relationship: part_of GO:0061525 ! hindgut development + +[Term] +id: GO:0007443 +name: Malpighian tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] +comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0061333 ! renal tubule morphogenesis +relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis +relationship: part_of GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0007444 +name: imaginal disc development +namespace: biological_process +def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] +is_a: GO:0035295 ! tube development +is_a: GO:0048513 ! animal organ development +is_a: GO:0060429 ! epithelium development + +[Term] +id: GO:0007445 +name: determination of imaginal disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007446 +name: imaginal disc growth +namespace: biological_process +def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] +is_a: GO:0035265 ! organ growth +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007447 +name: imaginal disc pattern formation +namespace: biological_process +def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007444 ! imaginal disc development + +[Term] +id: GO:0007448 +name: anterior/posterior pattern specification, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009952 ! anterior/posterior pattern specification + +[Term] +id: GO:0007449 +name: proximal/distal pattern formation, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0007450 +name: dorsal/ventral pattern formation, imaginal disc +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] +synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah] +synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah] +is_a: GO:0007447 ! imaginal disc pattern formation +is_a: GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0007451 +name: dorsal/ventral lineage restriction, imaginal disc +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] +synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah] +synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah] +is_a: GO:0035161 ! imaginal disc lineage restriction +relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc + +[Term] +id: GO:0007453 +name: clypeo-labral disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] +synonym: "clypeo-labral disc metamorphosis" EXACT [] +synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0007454 +name: labial disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] +synonym: "labial disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035217 ! labial disc development + +[Term] +id: GO:0007455 +name: eye-antennal disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] +synonym: "eye-antennal disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0007458 +name: progression of morphogenetic furrow involved in compound eye morphogenesis +namespace: biological_process +def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] +synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0007460 +name: R8 cell fate commitment +namespace: biological_process +alt_id: GO:0007461 +def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] +synonym: "restriction of R8 fate" EXACT [] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0007462 +name: R1/R6 cell fate commitment +namespace: biological_process +def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0048052 ! R1/R6 cell differentiation + +[Term] +id: GO:0007463 +name: R2/R5 cell fate commitment +namespace: biological_process +def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0048054 ! R2/R5 cell differentiation + +[Term] +id: GO:0007464 +name: R3/R4 cell fate commitment +namespace: biological_process +def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity +relationship: part_of GO:0048056 ! R3/R4 cell differentiation + +[Term] +id: GO:0007465 +name: R7 cell fate commitment +namespace: biological_process +def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] +is_a: GO:0001752 ! compound eye photoreceptor fate commitment +relationship: part_of GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0007468 +name: obsolete regulation of rhodopsin gene expression +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] +comment: This term was obsoleted because it referes to a specific gene product. The gene product should be captured as an annotation extension using 'has input'. +synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0007469 +name: antennal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0007470 +name: prothoracic disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] +synonym: "prothoracic disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035219 ! prothoracic disc development + +[Term] +id: GO:0007471 +name: obsolete prothoracic morphogenesis +namespace: biological_process +def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid] +comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. +synonym: "prothoracic morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0007470 + +[Term] +id: GO:0007472 +name: wing disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] +synonym: "wing disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0007473 +name: wing disc proximal/distal pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] +is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0007474 +name: imaginal disc-derived wing vein specification +namespace: biological_process +def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] +synonym: "wing vein specification" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0007475 +name: apposition of dorsal and ventral imaginal disc-derived wing surfaces +namespace: biological_process +def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] +synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis + +[Term] +id: GO:0007476 +name: imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] +synonym: "wing morphogenesis" EXACT [] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +relationship: part_of GO:0007472 ! wing disc morphogenesis + +[Term] +id: GO:0007477 +name: notum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0007478 +name: leg disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] +synonym: "leg disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035218 ! leg disc development + +[Term] +id: GO:0007479 +name: leg disc proximal/distal pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] +is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc +is_a: GO:0035223 ! leg disc pattern formation + +[Term] +id: GO:0007480 +name: imaginal disc-derived leg morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +relationship: part_of GO:0007478 ! leg disc morphogenesis + +[Term] +id: GO:0007481 +name: haltere disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] +synonym: "haltere disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035216 ! haltere disc development + +[Term] +id: GO:0007482 +name: haltere development +namespace: biological_process +def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] +is_a: GO:0048737 ! imaginal disc-derived appendage development +relationship: part_of GO:0035216 ! haltere disc development + +[Term] +id: GO:0007483 +name: genital disc morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] +synonym: "genital disc metamorphosis" EXACT [] +is_a: GO:0007560 ! imaginal disc morphogenesis +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007484 +name: imaginal disc-derived genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] +synonym: "genital development" BROAD [] +is_a: GO:0048806 ! genitalia development +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007485 +name: imaginal disc-derived male genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] +synonym: "male genital development" BROAD [] +is_a: GO:0007484 ! imaginal disc-derived genitalia development + +[Term] +id: GO:0007486 +name: imaginal disc-derived female genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] +synonym: "female genital development" BROAD [] +is_a: GO:0007484 ! imaginal disc-derived genitalia development +is_a: GO:0030540 ! female genitalia development + +[Term] +id: GO:0007487 +name: analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0007488 +name: histoblast morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] +synonym: "histoblast metamorphosis" EXACT [] +is_a: GO:0000902 ! cell morphogenesis +is_a: GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0007489 +name: maintenance of imaginal histoblast diploidy +namespace: biological_process +def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007490 +name: tergite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007491 +name: sternite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007488 ! histoblast morphogenesis + +[Term] +id: GO:0007492 +name: endoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007493 +name: endodermal cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. +synonym: "endoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001711 ! endodermal cell fate commitment + +[Term] +id: GO:0007494 +name: midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] +is_a: GO:0048565 ! digestive tract development + +[Term] +id: GO:0007495 +name: visceral mesoderm-endoderm interaction involved in midgut development +namespace: biological_process +def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] +synonym: "visceral mesoderm/endoderm interaction" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007496 +name: anterior midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007497 +name: posterior midgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007494 ! midgut development + +[Term] +id: GO:0007498 +name: mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] +subset: goslim_drosophila +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0007499 +name: ectoderm and mesoderm interaction +namespace: biological_process +def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] +synonym: "ectoderm/mesoderm interaction" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0007500 +name: mesodermal cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] +comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. +synonym: "mesoderm cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0001710 ! mesodermal cell fate commitment + +[Term] +id: GO:0007501 +name: mesodermal cell fate specification +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. +synonym: "mesoderm cell fate specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0001710 ! mesodermal cell fate commitment + +[Term] +id: GO:0007502 +name: digestive tract mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0007498 ! mesoderm development +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0007503 +name: fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0007504 +name: larval fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] +is_a: GO:0007503 ! fat body development +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0007505 +name: adult fat body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] +is_a: GO:0007503 ! fat body development + +[Term] +id: GO:0007506 +name: gonadal mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] +is_a: GO:0007498 ! mesoderm development +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0008406 ! gonad development + +[Term] +id: GO:0007507 +name: heart development +namespace: biological_process +alt_id: GO:0007511 +def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] +synonym: "cardiac development" RELATED [] +synonym: "dorsal vessel development" NARROW [] +xref: Wikipedia:Heart_development +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0072359 ! circulatory system development + +[Term] +id: GO:0007508 +name: larval heart development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:0879694238] +is_a: GO:0007507 ! heart development +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007509 +name: mesoderm migration involved in gastrulation +namespace: biological_process +def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] +is_a: GO:0008078 ! mesodermal cell migration +is_a: GO:0042074 ! cell migration involved in gastrulation +is_a: GO:0090130 ! tissue migration +relationship: part_of GO:0001707 ! mesoderm formation + +[Term] +id: GO:0007510 +name: cardioblast cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +is_a: GO:0060913 ! cardiac cell fate determination +relationship: part_of GO:0042684 ! cardioblast cell fate commitment + +[Term] +id: GO:0007512 +name: adult heart development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] +synonym: "adult cardiac development" RELATED [] +is_a: GO:0007507 ! heart development + +[Term] +id: GO:0007515 +name: obsolete lymph gland development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid] +comment: This term was made obsolete because it was wrongly defined. +synonym: "lymph gland development" EXACT [] +is_obsolete: true +consider: GO:0048535 +consider: GO:0048542 + +[Term] +id: GO:0007516 +name: hemocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "arthropod blood cell development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0007517 +name: muscle organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] +is_a: GO:0048513 ! animal organ development +is_a: GO:0061061 ! muscle structure development + +[Term] +id: GO:0007518 +name: myoblast fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048625 ! myoblast fate commitment + +[Term] +id: GO:0007519 +name: skeletal muscle tissue development +namespace: biological_process +alt_id: GO:0048637 +def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] +synonym: "myogenesis" RELATED [] +is_a: GO:0014706 ! striated muscle tissue development +relationship: part_of GO:0060538 ! skeletal muscle organ development + +[Term] +id: GO:0007520 +name: myoblast fusion +namespace: biological_process +def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion +relationship: part_of GO:0014902 ! myotube differentiation + +[Term] +id: GO:0007521 +name: muscle cell fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0042693 ! muscle cell fate commitment + +[Term] +id: GO:0007522 +name: visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0007517 ! muscle organ development + +[Term] +id: GO:0007523 +name: larval visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0007522 ! visceral muscle development +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007524 +name: adult visceral muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0007522 ! visceral muscle development + +[Term] +id: GO:0007525 +name: somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] +is_a: GO:0061061 ! muscle structure development + +[Term] +id: GO:0007526 +name: larval somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0007525 ! somatic muscle development +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0002164 ! larval development + +[Term] +id: GO:0007527 +name: adult somatic muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0007525 ! somatic muscle development + +[Term] +id: GO:0007528 +name: neuromuscular junction development +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] +synonym: "neuromuscular junction organization" EXACT [] +synonym: "neuromuscular junction stability" RELATED [GOC:pr] +synonym: "NMJ stability" RELATED [GOC:pr] +is_a: GO:0050808 ! synapse organization + +[Term] +id: GO:0007529 +name: establishment of synaptic specificity at neuromuscular junction +namespace: biological_process +def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:0007530 +name: sex determination +namespace: biological_process +def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] +xref: Wikipedia:Sex-determination_system +is_a: GO:0003006 ! developmental process involved in reproduction + +[Term] +id: GO:0007531 +name: mating type determination +namespace: biological_process +def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] +is_a: GO:0007530 ! sex determination +is_a: GO:0045165 ! cell fate commitment + +[Term] +id: GO:0007532 +name: regulation of mating-type specific transcription, DNA-templated +namespace: biological_process +def: "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +synonym: "mating-type specific transcriptional control" EXACT [] +synonym: "regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0007531 ! mating type determination + +[Term] +id: GO:0007533 +name: mating type switching +namespace: biological_process +def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] +synonym: "mating type switching and recombination" RELATED [] +is_a: GO:0007531 ! mating type determination +is_a: GO:0022413 ! reproductive process in single-celled organism + +[Term] +id: GO:0007534 +name: gene conversion at mating-type locus +namespace: biological_process +alt_id: GO:0000728 +alt_id: GO:0000734 +alt_id: GO:0010708 +alt_id: GO:0031292 +alt_id: GO:0034636 +alt_id: GO:0061500 +def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:10716938, PMID:7646483, PMID:9928492] +synonym: "gene conversion at mating-type locus, DNA double-strand break formation" NARROW [] +synonym: "gene conversion at mating-type locus, DNA double-strand break processing" NARROW [] +synonym: "gene conversion at mating-type locus, DNA repair synthesis" NARROW [] +synonym: "gene conversion at mating-type locus, termination of copy-synthesis" NARROW [] +synonym: "heteroduplex formation involved in gene conversion at mating-type locus" NARROW [] +synonym: "strand invasion involved in gene conversion at mating-type locus" EXACT [] +is_a: GO:0006312 ! mitotic recombination +is_a: GO:0022414 ! reproductive process +is_a: GO:0035822 ! gene conversion +relationship: part_of GO:0007533 ! mating type switching + +[Term] +id: GO:0007535 +name: donor selection +namespace: biological_process +def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492] +synonym: "donor preference" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0007533 ! mating type switching + +[Term] +id: GO:0007536 +name: activation of recombination (HML) +namespace: biological_process +def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] +is_a: GO:0007535 ! donor selection +is_a: GO:0045911 ! positive regulation of DNA recombination + +[Term] +id: GO:0007537 +name: inactivation of recombination (HML) +namespace: biological_process +def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] +is_a: GO:0007535 ! donor selection +is_a: GO:0045910 ! negative regulation of DNA recombination + +[Term] +id: GO:0007538 +name: primary sex determination +namespace: biological_process +def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007539 +name: primary sex determination, soma +namespace: biological_process +def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] +is_a: GO:0007538 ! primary sex determination +relationship: part_of GO:0018993 ! somatic sex determination + +[Term] +id: GO:0007540 +name: sex determination, establishment of X:A ratio +namespace: biological_process +def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete, GOC:mr, PMID:20622855, Wikipedia:XY_sex-determination_system] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0007539 ! primary sex determination, soma + +[Term] +id: GO:0007541 +name: sex determination, primary response to X:A ratio +namespace: biological_process +def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0007539 ! primary sex determination, soma + +[Term] +id: GO:0007542 +name: primary sex determination, germ-line +namespace: biological_process +def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] +is_a: GO:0007538 ! primary sex determination +relationship: part_of GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0007543 +name: sex determination, somatic-gonadal interaction +namespace: biological_process +def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] +synonym: "sex determination, somatic/gonadal interaction" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007542 ! primary sex determination, germ-line + +[Term] +id: GO:0007545 +name: processes downstream of sex determination signal +namespace: biological_process +def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007546 +name: somatic processes downstream of sex determination signal +namespace: biological_process +def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] +is_a: GO:0007545 ! processes downstream of sex determination signal + +[Term] +id: GO:0007547 +name: germ-line processes downstream of sex determination signal +namespace: biological_process +def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] +is_a: GO:0007545 ! processes downstream of sex determination signal +relationship: part_of GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0007548 +name: sex differentiation +namespace: biological_process +def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] +xref: Wikipedia:Sexual_differentiation +is_a: GO:0003006 ! developmental process involved in reproduction + +[Term] +id: GO:0007549 +name: dosage compensation +namespace: biological_process +def: "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] +xref: Wikipedia:Dosage_compensation +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0007550 +name: obsolete establishment of dosage compensation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete] +comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. +synonym: "establishment of dosage compensation" EXACT [] +is_obsolete: true +consider: GO:0007549 + +[Term] +id: GO:0007551 +name: obsolete maintenance of dosage compensation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:isa_complete] +comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. +synonym: "maintenance of dosage compensation" EXACT [] +is_obsolete: true +consider: GO:0007549 + +[Term] +id: GO:0007552 +name: metamorphosis +namespace: biological_process +alt_id: GO:0046698 +alt_id: GO:0046699 +def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] +xref: Wikipedia:Metamorphosis +is_a: GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007553 +name: regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] +synonym: "regulation of ecdysteroid metabolism" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0007554 +name: regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "regulation of ecdysteroid anabolism" EXACT [] +synonym: "regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "regulation of ecdysteroid formation" EXACT [] +synonym: "regulation of ecdysteroid synthesis" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process +relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0007555 +name: regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators] +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0007556 +name: regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone metabolism" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: part_of GO:0002165 ! instar larval or pupal development +relationship: regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0007557 +name: regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone anabolism" EXACT [] +synonym: "regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "regulation of juvenile hormone formation" EXACT [] +synonym: "regulation of juvenile hormone synthesis" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0007558 +name: regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0007559 +name: obsolete histolysis +namespace: biological_process +def: "OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] +comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. +xref: Wikipedia:Histolysis +is_obsolete: true +consider: GO:0008219 +consider: GO:0012501 + +[Term] +id: GO:0007560 +name: imaginal disc morphogenesis +namespace: biological_process +alt_id: GO:0007452 +def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] +synonym: "imaginal disc metamorphosis" EXACT [] +is_a: GO:0048563 ! post-embryonic animal organ morphogenesis +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0007444 ! imaginal disc development +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0007561 +name: imaginal disc eversion +namespace: biological_process +def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0007562 +name: eclosion +namespace: biological_process +def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] +xref: Wikipedia:Pupa#Emergence +is_a: GO:0071684 ! organism emergence from protective structure +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0007563 +name: regulation of eclosion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0007562 ! eclosion + +[Term] +id: GO:0007564 +name: regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] +synonym: "regulation of cuticle hardening" NARROW [] +synonym: "regulation of cuticle tanning" EXACT [] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0007593 ! chitin-based cuticle sclerotization + +[Term] +id: GO:0007565 +name: female pregnancy +namespace: biological_process +def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] +subset: goslim_chembl +synonym: "carrying of young" RELATED [] +synonym: "gestation" EXACT [] +xref: Wikipedia:Gestation +is_a: GO:0044703 ! multi-organism reproductive process +is_a: GO:0044706 ! multi-multicellular organism process + +[Term] +id: GO:0007566 +name: embryo implantation +namespace: biological_process +def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] +synonym: "blastocyst implantation" EXACT [] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007275 ! multicellular organism development +relationship: part_of GO:0007565 ! female pregnancy + +[Term] +id: GO:0007567 +name: parturition +namespace: biological_process +def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732] +synonym: "egg laying" NARROW [] +synonym: "giving birth" EXACT [] +is_a: GO:0044703 ! multi-organism reproductive process +is_a: GO:0044706 ! multi-multicellular organism process + +[Term] +id: GO:0007568 +name: aging +namespace: biological_process +alt_id: GO:0016280 +def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +synonym: "ageing" EXACT [] +xref: Wikipedia:Aging +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0007569 +name: cell aging +namespace: biological_process +def: "An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators] +synonym: "cell ageing" EXACT [] +is_a: GO:0007568 ! aging +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0007570 +name: obsolete age dependent accumulation of genetic damage +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "age dependent accumulation of genetic damage" EXACT [] +is_obsolete: true +consider: GO:0001301 + +[Term] +id: GO:0007571 +name: age-dependent general metabolic decline +namespace: biological_process +def: "A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807] +synonym: "age-dependent decreased translational activity" NARROW [] +synonym: "age-dependent increased protein content" NARROW [] +synonym: "age-dependent yeast cell size increase" RELATED [] +synonym: "nucleolar size increase" NARROW [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007568 ! aging + +[Term] +id: GO:0007572 +name: obsolete age dependent decreased translational activity +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "age dependent decreased translational activity" EXACT [] +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007573 +name: obsolete age dependent increased protein content +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "age dependent increased protein content" EXACT [] +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007574 +name: obsolete cell aging (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] +comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. +synonym: "cell aging (sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0007569 + +[Term] +id: GO:0007575 +name: obsolete nucleolar size increase +namespace: biological_process +def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "nucleolar size increase" EXACT [] +is_obsolete: true +consider: GO:0007571 +consider: GO:0007576 + +[Term] +id: GO:0007576 +name: nucleolar fragmentation +namespace: biological_process +alt_id: GO:0046616 +def: "The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578] +synonym: "nucleolar size increase" RELATED [] +is_a: GO:0007000 ! nucleolus organization +relationship: part_of GO:0007569 ! cell aging + +[Term] +id: GO:0007577 +name: obsolete autophagic death (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] +comment: This term was made obsolete because a more correct term has been created. +synonym: "autophagic death (sensu Saccharomyces)" EXACT [] +is_obsolete: true +consider: GO:0048102 + +[Term] +id: GO:0007578 +name: obsolete aging dependent sterility (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] +comment: This term was made obsolete because it reflected a trait or phenotype. +synonym: "aging dependent sterility (sensu Saccharomyces)" EXACT [] +is_obsolete: true +consider: GO:0030466 + +[Term] +id: GO:0007579 +name: obsolete senescence factor accumulation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jh] +comment: This term was made obsolete because it does not represent a process. +synonym: "senescence factor accumulation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007580 +name: extrachromosomal circular DNA accumulation involved in cell aging +namespace: biological_process +def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] +comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. +synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED [] +synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging + +[Term] +id: GO:0007581 +name: obsolete age-dependent yeast cell size increase +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "age-dependent yeast cell size increase" EXACT [] +is_obsolete: true +consider: GO:0007571 + +[Term] +id: GO:0007583 +name: obsolete killer activity +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. +synonym: "killer activity" EXACT [] +is_obsolete: true +consider: GO:0042267 + +[Term] +id: GO:0007584 +name: response to nutrient +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] +synonym: "nutritional response pathway" NARROW [] +synonym: "response to nutrients" EXACT [] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0007585 +name: respiratory gaseous exchange by respiratory system +namespace: biological_process +def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] +subset: goslim_chembl +synonym: "breathing" BROAD [] +synonym: "respiration" BROAD [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007586 +name: digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_pir +xref: Wikipedia:Digestion +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007588 +name: excretion +namespace: biological_process +def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] +subset: gocheck_do_not_annotate +subset: goslim_pir +xref: Wikipedia:Excretion +is_a: GO:0003008 ! system process + +[Term] +id: GO:0007589 +name: body fluid secretion +namespace: biological_process +def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0046903 ! secretion +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0007590 +name: obsolete fat body metabolic process (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732] +comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. +synonym: "fat body metabolic process (sensu Insecta)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0007591 +name: molting cycle, chitin-based cuticle +namespace: biological_process +def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] +synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0007592 +name: obsolete protein-based cuticle development +namespace: biological_process +def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] +comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. +synonym: "protein-based cuticle anabolism" EXACT [] +synonym: "protein-based cuticle biosynthetic process" EXACT [] +synonym: "protein-based cuticle development" EXACT [] +synonym: "protein-based cuticle formation" EXACT [] +synonym: "protein-based cuticle synthesis" EXACT [] +is_obsolete: true +consider: GO:0040002 +consider: GO:0040003 + +[Term] +id: GO:0007593 +name: chitin-based cuticle sclerotization +namespace: biological_process +alt_id: GO:0045452 +def: "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu] +synonym: "chitin-based cuticle tanning" RELATED [GOC:bf, GOC:dos, GOC:sart] +synonym: "cuticle hardening" NARROW [] +is_a: GO:0007591 ! molting cycle, chitin-based cuticle +is_a: GO:0021700 ! developmental maturation +is_a: GO:0022404 ! molting cycle process + +[Term] +id: GO:0007594 +name: puparial adhesion +namespace: biological_process +def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] +synonym: "puparial glue" RELATED [] +is_a: GO:0022609 ! multicellular organism adhesion to substrate +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0007595 +name: lactation +namespace: biological_process +def: "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." [ISBN:0198506732] +synonym: "milk secretion" EXACT [GOC:pr] +xref: Wikipedia:Lactation +is_a: GO:0007589 ! body fluid secretion +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0007596 +name: blood coagulation +namespace: biological_process +def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732] +synonym: "blood clotting" EXACT [] +xref: Wikipedia:Coagulation +is_a: GO:0007599 ! hemostasis +is_a: GO:0050817 ! coagulation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0007597 +name: blood coagulation, intrinsic pathway +namespace: biological_process +def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] +comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. +is_a: GO:0072376 ! protein activation cascade +relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation + +[Term] +id: GO:0007598 +name: blood coagulation, extrinsic pathway +namespace: biological_process +def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] +comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. +is_a: GO:0072376 ! protein activation cascade +relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation + +[Term] +id: GO:0007599 +name: hemostasis +namespace: biological_process +def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] +xref: Wikipedia:Hemostasis +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0007600 +name: sensory perception +namespace: biological_process +def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] +subset: goslim_drosophila +xref: Wikipedia:Perception +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0007601 +name: visual perception +namespace: biological_process +def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] +synonym: "sense of sight" EXACT [] +synonym: "sensory visual perception" EXACT [] +synonym: "vision" EXACT [] +xref: Wikipedia:Visual_perception +is_a: GO:0050953 ! sensory perception of light stimulus + +[Term] +id: GO:0007602 +name: phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] +synonym: "opsin" RELATED [] +synonym: "phototransduction, visible light, light adaptation" NARROW [] +synonym: "phototrophin mediated phototransduction" NARROW [] +xref: Wikipedia:Visual_phototransduction +is_a: GO:0007165 ! signal transduction +is_a: GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0007603 +name: phototransduction, visible light +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] +synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721] +synonym: "visual transduction" EXACT [PMID:10611962] +is_a: GO:0007602 ! phototransduction +is_a: GO:0009584 ! detection of visible light + +[Term] +id: GO:0007604 +name: phototransduction, UV +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] +synonym: "phototransduction, ultraviolet light" EXACT [] +synonym: "phototransduction, ultraviolet radiation" EXACT [] +synonym: "phototransduction, UV light" EXACT [] +synonym: "phototransduction, UV radiation" EXACT [] +synonym: "UV-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction +is_a: GO:0009589 ! detection of UV +is_a: GO:0034644 ! cellular response to UV + +[Term] +id: GO:0007605 +name: sensory perception of sound +namespace: biological_process +def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] +synonym: "hearing" EXACT [] +synonym: "perception of sound" EXACT [] +xref: Wikipedia:Hearing_(sense) +is_a: GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0007606 +name: sensory perception of chemical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "chemosensory perception" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0007607 +name: obsolete taste perception +namespace: biological_process +def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] +comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. +synonym: "taste perception" EXACT [] +is_obsolete: true +consider: GO:0050909 +consider: GO:0050912 + +[Term] +id: GO:0007608 +name: sensory perception of smell +namespace: biological_process +def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai] +synonym: "olfaction" EXACT [] +synonym: "scent perception" EXACT [] +synonym: "sense of smell" EXACT [] +synonym: "smell perception" EXACT [] +xref: Wikipedia:Olfaction +is_a: GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0007610 +name: behavior +namespace: biological_process +alt_id: GO:0023032 +alt_id: GO:0044708 +alt_id: GO:0044709 +def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] +comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). +subset: gocheck_do_not_manually_annotate +subset: goslim_agr +subset: goslim_flybase_ribbon +synonym: "behavioral response to stimulus" EXACT [] +synonym: "behaviour" EXACT [] +synonym: "behavioural response to stimulus" EXACT [] +synonym: "single-organism behavior" RELATED [] +xref: Wikipedia:Behavior +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0007611 +name: learning or memory +namespace: biological_process +def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] +is_a: GO:0007610 ! behavior +is_a: GO:0050890 ! cognition + +[Term] +id: GO:0007612 +name: learning +namespace: biological_process +def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] +xref: Wikipedia:Learning +is_a: GO:0007611 ! learning or memory + +[Term] +id: GO:0007613 +name: memory +namespace: biological_process +def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, ISBN:0582227089] +xref: Wikipedia:Memory +is_a: GO:0007611 ! learning or memory + +[Term] +id: GO:0007614 +name: short-term memory +namespace: biological_process +def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] +xref: Wikipedia:Short-term_memory +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007615 +name: anesthesia-resistant memory +namespace: biological_process +def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007616 +name: long-term memory +namespace: biological_process +def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] +xref: Wikipedia:Long-term_memory +is_a: GO:0007613 ! memory + +[Term] +id: GO:0007617 +name: mating behavior +namespace: biological_process +def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] +synonym: "mating behaviour" EXACT [] +xref: Wikipedia:Mating_behaviour +is_a: GO:0019098 ! reproductive behavior +relationship: part_of GO:0007618 ! mating + +[Term] +id: GO:0007618 +name: mating +namespace: biological_process +def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] +is_a: GO:0044703 ! multi-organism reproductive process +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0007619 +name: courtship behavior +namespace: biological_process +def: "The behavior of an organism for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] +synonym: "courtship behaviour" EXACT [] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0007620 +name: copulation +namespace: biological_process +def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] +is_a: GO:0007618 ! mating + +[Term] +id: GO:0007621 +name: negative regulation of female receptivity +namespace: biological_process +def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] +synonym: "down regulation of female receptivity" EXACT [] +synonym: "down-regulation of female receptivity" EXACT [] +synonym: "downregulation of female receptivity" EXACT [] +synonym: "inhibition of female receptivity" NARROW [] +is_a: GO:0045924 ! regulation of female receptivity + +[Term] +id: GO:0007622 +name: rhythmic behavior +namespace: biological_process +def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] +synonym: "rhythmic behavioral response to stimulus" EXACT [] +synonym: "rhythmic behaviour" EXACT [] +synonym: "rhythmic behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007623 +name: circadian rhythm +namespace: biological_process +alt_id: GO:0050895 +def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] +subset: goslim_drosophila +subset: goslim_plant +synonym: "circadian process" EXACT [] +synonym: "circadian response" RELATED [] +synonym: "response to circadian rhythm" RELATED [] +xref: Wikipedia:Circadian_rhythm +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007624 +name: ultradian rhythm +namespace: biological_process +def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721] +is_a: GO:0048511 ! rhythmic process + +[Term] +id: GO:0007625 +name: grooming behavior +namespace: biological_process +def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] +synonym: "grooming behaviour" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007626 +name: locomotory behavior +namespace: biological_process +def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] +subset: goslim_drosophila +synonym: "behavior via locomotion" EXACT [] +synonym: "locomotion in response to stimulus" EXACT [] +synonym: "locomotory behavioral response to stimulus" EXACT [] +synonym: "locomotory behaviour" EXACT [] +synonym: "locomotory behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007627 +name: obsolete larval behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "larval behavior (sensu Insecta)" EXACT [] +is_obsolete: true +replaced_by: GO:0030537 + +[Term] +id: GO:0007628 +name: adult walking behavior +namespace: biological_process +def: "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] +synonym: "adult walking behaviour" EXACT [] +is_a: GO:0008344 ! adult locomotory behavior +is_a: GO:0090659 ! walking behavior + +[Term] +id: GO:0007629 +name: flight behavior +namespace: biological_process +def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] +synonym: "flight behaviour" EXACT [] +is_a: GO:0008344 ! adult locomotory behavior + +[Term] +id: GO:0007630 +name: jump response +namespace: biological_process +def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] +is_a: GO:0008344 ! adult locomotory behavior + +[Term] +id: GO:0007631 +name: feeding behavior +namespace: biological_process +alt_id: GO:0044366 +alt_id: GO:0044367 +alt_id: GO:0044368 +alt_id: GO:0044369 +alt_id: GO:0044370 +alt_id: GO:0044371 +alt_id: GO:0044372 +def: "Behavior associated with the intake of food." [GOC:mah] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "behavioral response to food" EXACT [] +synonym: "behavioural response to food" EXACT [] +synonym: "eating" NARROW [] +synonym: "feeding behaviour" EXACT [] +synonym: "feeding from phloem of other organism" NARROW [] +synonym: "feeding from plant phloem" NARROW [] +synonym: "feeding from tissue of other organism" NARROW [] +synonym: "feeding from vascular tissue of another organism" NARROW [] +synonym: "feeding from xylem of other organism" NARROW [] +synonym: "feeding on blood of other organism" NARROW [] +synonym: "feeding on or from other organism" NARROW [] +synonym: "feeding on plant sap" NARROW [] +synonym: "hematophagy" NARROW [] +synonym: "injection of substance into other organism during feeding on blood of other organism" NARROW [] +synonym: "taking of blood meal" NARROW [] +xref: Wikipedia:List_of_feeding_behaviours +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0007632 +name: visual behavior +namespace: biological_process +def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] +synonym: "behavioral response to visual stimulus" EXACT [] +synonym: "behavioural response to visual stimulus" EXACT [] +synonym: "visual behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0007633 +name: pattern orientation +namespace: biological_process +def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535] +synonym: "behavioral response to pattern orientation" EXACT [] +synonym: "behavioural response to pattern orientation" EXACT [] +is_a: GO:0007632 ! visual behavior + +[Term] +id: GO:0007634 +name: optokinetic behavior +namespace: biological_process +def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr] +synonym: "optokinetic behaviour" EXACT [] +is_a: GO:0007632 ! visual behavior + +[Term] +id: GO:0007635 +name: chemosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] +synonym: "behavioral response to chemical stimulus" EXACT [] +synonym: "behavioural response to chemical stimulus" EXACT [] +synonym: "chemosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0007636 +name: chemosensory jump behavior +namespace: biological_process +def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid] +synonym: "chemosensory jump behaviour" EXACT [] +synonym: "jump response to chemical stimulus" EXACT [] +is_a: GO:0007630 ! jump response +is_a: GO:0007635 ! chemosensory behavior + +[Term] +id: GO:0007637 +name: proboscis extension reflex +namespace: biological_process +def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus." [FB:FBrf0044924, GOC:jid] +synonym: "behavioral response to nutritional stimulus, proboscis extension" EXACT [] +synonym: "proboscis extension in response to nutritional stimulus" EXACT [] +is_a: GO:0007635 ! chemosensory behavior +is_a: GO:0051780 ! behavioral response to nutrient +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0007638 +name: mechanosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] +synonym: "behavioral response to mechanical stimulus" EXACT [] +synonym: "behavioural response to mechanical stimulus" EXACT [] +synonym: "mechanosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0007639 +name: homeostasis of number of meristem cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0008001 +name: obsolete fibrinogen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it does not describe an activity. +synonym: "fibrinogen" EXACT [] +is_obsolete: true +replaced_by: GO:0005577 + +[Term] +id: GO:0008002 +name: obsolete lamina lucida +namespace: cellular_component +def: "OBSOLETE. The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] +comment: This term was made obsolete because it is thought to be an experimental artefact. +xref: Wikipedia:Lamina_lucida +is_obsolete: true + +[Term] +id: GO:0008004 +name: obsolete lamina reticularis +namespace: cellular_component +def: "OBSOLETE. A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] +comment: This term was obsoleted because as a layer of the basement membrane, the lamina reticularis is thought to be an artefact. See PMID:24137544 and PMID:8061357. +is_obsolete: true +replaced_by: GO:0005604 + +[Term] +id: GO:0008008 +name: obsolete membrane attack complex protein beta2 chain +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "membrane attack complex protein beta2 chain" EXACT [] +is_obsolete: true +replaced_by: GO:0005579 + +[Term] +id: GO:0008009 +name: chemokine activity +namespace: molecular_function +def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine] +subset: goslim_chembl +is_a: GO:0005125 ! cytokine activity +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0008010 +name: structural constituent of chitin-based larval cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of larval cuticle" BROAD [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008011 +name: structural constituent of pupal chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of pupal cuticle" BROAD [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008012 +name: structural constituent of adult chitin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] +synonym: "structural constituent of adult cuticle" BROAD [] +is_a: GO:0005214 ! structural constituent of chitin-based cuticle + +[Term] +id: GO:0008013 +name: beta-catenin binding +namespace: molecular_function +def: "Binding to a catenin beta subunit." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008014 +name: obsolete calcium-dependent cell adhesion molecule activity +namespace: molecular_function +alt_id: GO:0001538 +def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "cadherin" NARROW [] +synonym: "calcium-dependent cell adhesion molecule activity" EXACT [] +is_obsolete: true +consider: GO:0005515 +consider: GO:0016021 +consider: GO:0016339 + +[Term] +id: GO:0008015 +name: blood circulation +namespace: biological_process +alt_id: GO:0070261 +def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] +subset: goslim_pir +synonym: "hemolymph circulation" RELATED [] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:0008016 +name: regulation of heart contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of cardiac contraction" EXACT [] +is_a: GO:1903522 ! regulation of blood circulation +relationship: regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0008017 +name: microtubule binding +namespace: molecular_function +def: "Binding to a microtubule, a filament composed of tubulin monomers." [GOC:krc] +synonym: "microtubule severing activity" RELATED [] +synonym: "microtubule/chromatin interaction" RELATED [] +xref: Reactome:R-HSA-9614343 "Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs" +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0008018 +name: obsolete structural protein of chorion (sensu Drosophila) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the function is covered by a parent term. +synonym: "structural protein of chorion (sensu Drosophila)" EXACT [] +is_obsolete: true +replaced_by: GO:0005213 + +[Term] +id: GO:0008019 +name: obsolete macrophage receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because its name is ambiguous, and it was never defined. +synonym: "macrophage receptor activity" EXACT [] +is_obsolete: true +consider: GO:0005044 +consider: GO:0038187 + +[Term] +id: GO:0008020 +name: G protein-coupled photoreceptor activity +namespace: molecular_function +alt_id: GO:0004975 +def: "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] +synonym: "G protein coupled photoreceptor activity" EXACT [] +synonym: "G-protein coupled photoreceptor activity" EXACT [] +synonym: "photoreceptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0008021 +name: synaptic vesicle +namespace: cellular_component +def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290] +comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. +subset: goslim_synapse +synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667] +xref: NIF_Subcellular:sao1071221672 +xref: Wikipedia:Synaptic_vesicle +is_a: GO:0070382 ! exocytic vesicle +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0008022 +name: protein C-terminus binding +namespace: molecular_function +def: "Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] +subset: goslim_chembl +synonym: "C-terminal binding" EXACT [] +synonym: "C-terminal end binding" EXACT [GOC:sl] +synonym: "carboxy-terminal binding" RELATED [GOC:jsg] +synonym: "carboxy-terminus binding" RELATED [GOC:sl] +synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] +synonym: "carboxyl-terminus binding" RELATED [GOC:sl] +synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] +synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] +synonym: "COOH-terminal binding" NARROW [GOC:jsg] +synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008023 +name: transcription elongation factor complex +namespace: cellular_component +def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0008024 +name: cyclin/CDK positive transcription elongation factor complex +namespace: cellular_component +def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] +comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. +synonym: "positive transcription elongation factor complex b" RELATED [] +is_a: GO:0008023 ! transcription elongation factor complex +is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex +is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex + +[Term] +id: GO:0008025 +name: obsolete diazepam binding inhibitor activity +namespace: molecular_function +def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732, PMID:11883709] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "DBI" EXACT [] +synonym: "diazepam binding inhibitor activity" EXACT [] +synonym: "diazepam-binding inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0004857 +consider: GO:0030156 +consider: GO:0050796 +consider: GO:0050809 +consider: GO:0050810 +consider: GO:0050811 +consider: GO:0050812 + +[Term] +id: GO:0008028 +name: monocarboxylic acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008505 +def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] +synonym: "monocarboxylate carrier" NARROW [] +synonym: "prostaglandin/thromboxane transporter activity" NARROW [] +xref: Reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" +xref: Reactome:R-HSA-433698 "SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5624211 "Defective SLC16A1 does not cotransport monocarboxylates, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-9645220 "SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0008029 +name: pentraxin receptor activity +namespace: molecular_function +def: "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). +synonym: "pentaxin receptor" EXACT [] +is_a: GO:0001847 ! opsonin receptor activity + +[Term] +id: GO:0008030 +name: neuronal pentraxin receptor activity +namespace: molecular_function +def: "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:18840757] +synonym: "neuronal pentaxin receptor" EXACT [] +is_a: GO:0008029 ! pentraxin receptor activity + +[Term] +id: GO:0008031 +name: eclosion hormone activity +namespace: molecular_function +def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732] +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0008033 +name: tRNA processing +namespace: biological_process +def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] +subset: goslim_yeast +synonym: "tRNA maturation" EXACT [GOC:vw] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0008034 +name: obsolete lipoprotein binding +namespace: molecular_function +def: "OBSOLETE. Binding to a conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning. +synonym: "lipoprotein binding" EXACT [] +is_obsolete: true +consider: GO:0071723 +consider: GO:0071813 + +[Term] +id: GO:0008035 +name: high-density lipoprotein particle binding +namespace: molecular_function +def: "Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah] +synonym: "HDL binding" EXACT [GOC:mah] +is_a: GO:0071813 ! lipoprotein particle binding + +[Term] +id: GO:0008036 +name: diuretic hormone receptor activity +namespace: molecular_function +def: "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0008037 +name: cell recognition +namespace: biological_process +def: "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] +subset: goslim_pir +synonym: "recognition of surroundings by cell" EXACT [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0008038 +name: neuron recognition +namespace: biological_process +def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] +synonym: "neuronal cell recognition" EXACT [] +is_a: GO:0008037 ! cell recognition +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0008039 +name: synaptic target recognition +namespace: biological_process +def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] +subset: goslim_synapse +synonym: "neuronal targeting" EXACT [] +is_a: GO:0008038 ! neuron recognition + +[Term] +id: GO:0008041 +name: obsolete storage protein of fat body (sensu Insecta) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it describes a cellular location rather than a function. +synonym: "storage protein of fat body (sensu Insecta)" EXACT [] +is_obsolete: true +replaced_by: GO:0045735 + +[Term] +id: GO:0008042 +name: obsolete iron-sulfur electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "ferredoxin" NARROW [] +synonym: "iron-sulfur electron transfer carrier" EXACT [] +synonym: "iron-sulphur electron transfer carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0008043 +name: intracellular ferritin complex +namespace: cellular_component +def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717] +is_a: GO:0070288 ! ferritin complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0008044 +name: obsolete adult behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "adult behavior (sensu Insecta)" EXACT [] +is_obsolete: true +replaced_by: GO:0030534 + +[Term] +id: GO:0008045 +name: motor neuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] +synonym: "motoneuron axon guidance" EXACT [] +synonym: "motor axon guidance" EXACT [] +synonym: "motor axon pathfinding" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0008046 +name: axon guidance receptor activity +namespace: molecular_function +def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666] +synonym: "receptor activity involved in axon guidance" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0008047 +name: enzyme activator activity +namespace: molecular_function +alt_id: GO:0010577 +def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +synonym: "metalloenzyme activator activity" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0008048 +name: calcium sensitive guanylate cyclase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah] +is_a: GO:0030250 ! guanylate cyclase activator activity + +[Term] +id: GO:0008049 +name: male courtship behavior +namespace: biological_process +alt_id: GO:0016542 +def: "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] +synonym: "male courtship behaviour" EXACT [] +is_a: GO:0007619 ! courtship behavior +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0008050 +name: female courtship behavior +namespace: biological_process +def: "The behavior of a female, for the purpose of attracting a sexual partner." [GOC:bf, GOC:pr] +synonym: "female courtship behaviour" EXACT [] +is_a: GO:0007619 ! courtship behavior +is_a: GO:0060180 ! female mating behavior + +[Term] +id: GO:0008051 +name: obsolete farnesyl-diphosphate farnesyl transferase complex +namespace: cellular_component +def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] +comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. +synonym: "farnesyl-diphosphate farnesyl transferase complex" EXACT [] +is_obsolete: true +consider: GO:0004310 + +[Term] +id: GO:0008052 +name: sensory organ boundary specification +namespace: biological_process +def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021] +synonym: "sense organ boundary specification" EXACT [GOC:dph] +is_a: GO:0010160 ! formation of animal organ boundary +relationship: part_of GO:0007423 ! sensory organ development + +[Term] +id: GO:0008053 +name: mitochondrial fusion +namespace: biological_process +def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0048284 ! organelle fusion + +[Term] +id: GO:0008055 +name: ocellus pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] +synonym: "ocellus pigment anabolism" EXACT [] +synonym: "ocellus pigment biosynthesis" EXACT [] +synonym: "ocellus pigment formation" EXACT [] +synonym: "ocellus pigment synthesis" EXACT [] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0046158 ! ocellus pigment metabolic process + +[Term] +id: GO:0008056 +name: ocellus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0035214 ! eye-antennal disc development + +[Term] +id: GO:0008057 +name: eye pigment granule organization +namespace: biological_process +alt_id: GO:0008059 +alt_id: GO:0045318 +alt_id: GO:0048751 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] +synonym: "eye pigment granule organisation" EXACT [GOC:mah] +synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0008058 +name: ocellus pigment granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] +synonym: "ocellus pigment granule organisation" EXACT [] +synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0008061 +name: chitin binding +namespace: molecular_function +def: "Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] +subset: goslim_drosophila +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0008062 +name: eclosion rhythm +namespace: biological_process +def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] +is_a: GO:0048512 ! circadian behavior +relationship: part_of GO:0007562 ! eclosion + +[Term] +id: GO:0008063 +name: Toll signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] +synonym: "Tl signaling pathway" EXACT [] +synonym: "Tl signalling pathway" EXACT [] +synonym: "Toll signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0008064 +name: regulation of actin polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] +is_a: GO:0030832 ! regulation of actin filament length +is_a: GO:0110053 ! regulation of actin filament organization +relationship: regulates GO:0008154 ! actin polymerization or depolymerization + +[Term] +id: GO:0008065 +name: establishment of blood-nerve barrier +namespace: biological_process +def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] +synonym: "establishment of blood/nerve barrier" EXACT [] +is_a: GO:0001885 ! endothelial cell development +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0008066 +name: glutamate receptor activity +namespace: molecular_function +def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0008067 +name: obsolete metabotropic glutamate, GABA-B-like receptor activity +namespace: molecular_function +alt_id: GO:0001643 +alt_id: GO:0001645 +def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] +comment: This term was made obsolete because it represents a gene product and is named based on protein features. +synonym: "class C G protein coupled receptor" BROAD [] +synonym: "class C G-protein coupled receptor" BROAD [] +synonym: "class C GPCR" BROAD [] +synonym: "class C orphan receptor activity" EXACT [] +synonym: "metabotropic glutamate, GABA-B-like receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0008068 +name: extracellularly glutamate-gated chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. +synonym: "extracellular-glutamate-gated chloride channel activity" EXACT [] +is_a: GO:0005234 ! extracellularly glutamate-gated ion channel activity +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0099095 ! ligand-gated anion channel activity + +[Term] +id: GO:0008069 +name: dorsal/ventral axis specification, ovarian follicular epithelium +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] +synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] +synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED [] +synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] +synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009950 ! dorsal/ventral axis specification +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0008070 +name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] +synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] +is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium + +[Term] +id: GO:0008071 +name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded +namespace: biological_process +def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] +synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD [] +synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] +is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium + +[Term] +id: GO:0008073 +name: ornithine decarboxylase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of ornithine decarboxylase." [GOC:jl] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0042979 ! ornithine decarboxylase regulator activity + +[Term] +id: GO:0008074 +name: guanylate cyclase complex, soluble +namespace: cellular_component +def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] +comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0008075 +name: obsolete receptor guanylate cyclase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "receptor guanylate cyclase activity" EXACT [] +is_obsolete: true +consider: GO:0004383 +consider: GO:0038023 + +[Term] +id: GO:0008076 +name: voltage-gated potassium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] +synonym: "voltage gated potassium channel complex" EXACT [] +synonym: "voltage-dependent potassium channel complex" EXACT [] +synonym: "voltage-sensitive potassium channel complex" EXACT [] +xref: NIF_Subcellular:sao371494298 +is_a: GO:0034705 ! potassium channel complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0008077 +name: obsolete Hsp70/Hsp90 organizing protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:rb] +comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. +synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] +synonym: "Hsp70/Hsp90 organizing protein activity" EXACT [] +is_obsolete: true +consider: GO:0030674 + +[Term] +id: GO:0008078 +name: mesodermal cell migration +namespace: biological_process +def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] +synonym: "mesoderm cell migration" EXACT [] +is_a: GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0008079 +name: translation termination factor activity +namespace: molecular_function +def: "Functions in the termination of translation." [GOC:ma] +is_a: GO:0008135 ! translation factor activity, RNA binding + +[Term] +id: GO:0008080 +name: N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2" +xref: Reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2" +xref: Reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842" +xref: Reactome:R-HSA-9636560 "Eis acetylates DUSP16" +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0008081 +name: phosphoric diester hydrolase activity +namespace: molecular_function +alt_id: GO:0004434 +alt_id: GO:0016792 +def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4.-, GOC:curators] +subset: goslim_chembl +synonym: "phosphodiesterase" NARROW [] +xref: EC:3.1.4.- +xref: Reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends" +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0008083 +name: growth factor activity +namespace: molecular_function +def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] +comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. +subset: goslim_chembl +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0008084 +name: imaginal disc growth factor receptor binding +namespace: molecular_function +def: "Binding to an imaginal disc growth factor receptor." [GOC:mah] +synonym: "imaginal disc growth factor" NARROW [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0008085 +name: obsolete phototransduction, visible light, light adaptation +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because the term name is ambiguous. +synonym: "phototransduction, visible light, light adaptation" EXACT [] +is_obsolete: true +consider: GO:0007602 + +[Term] +id: GO:0008086 +name: light-activated voltage-gated calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport] +synonym: "light-activated voltage gated calcium channel activity" EXACT [] +synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] +is_a: GO:0005245 ! voltage-gated calcium channel activity +is_a: GO:0010461 ! light-activated ion channel activity + +[Term] +id: GO:0008087 +name: light-activated voltage-gated calcium channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] +synonym: "light-activated voltage gated calcium channel complex" EXACT [] +synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] +synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] +is_a: GO:0005891 ! voltage-gated calcium channel complex + +[Term] +id: GO:0008088 +name: axo-dendritic transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] +subset: goslim_synapse +synonym: "axon cargo transport" NARROW [] +synonym: "axonal transport" NARROW [] +synonym: "axoplasmic transport" NARROW [] +xref: Wikipedia:Axoplasmic_transport +is_a: GO:0010970 ! transport along microtubule + +[Term] +id: GO:0008089 +name: anterograde axonal transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] +subset: goslim_synapse +synonym: "anterograde axon cargo transport" EXACT [] +is_a: GO:0098930 ! axonal transport + +[Term] +id: GO:0008090 +name: retrograde axonal transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] +subset: goslim_synapse +synonym: "retrograde axon cargo transport" EXACT [] +is_a: GO:0098930 ! axonal transport + +[Term] +id: GO:0008091 +name: spectrin +namespace: cellular_component +def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] +xref: NIF_Subcellular:sao536287099 +xref: Wikipedia:Spectrin +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0008092 +name: cytoskeletal protein binding +namespace: molecular_function +def: "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_yeast +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008093 +name: cytoskeletal anchor activity +namespace: molecular_function +def: "The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:30323238] +synonym: "cytoskeletal adaptor activity" EXACT [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0008094 +name: ATP-dependent activity, acting on DNA +namespace: molecular_function +alt_id: GO:0004011 +def: "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] +synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] +synonym: "ATPase activity, acting on DNA" EXACT [] +synonym: "ATPase, acting on DNA" EXACT [] +synonym: "DNA dependent ATPase activity" EXACT [] +synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] +synonym: "DNA-dependent ATPase activity" EXACT [] +is_a: GO:0140097 ! catalytic activity, acting on DNA +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0008096 +name: juvenile hormone epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141] +xref: EC:3.3.2.- +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0008097 +name: 5S rRNA binding +namespace: molecular_function +def: "Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0008098 +name: 5S rRNA primary transcript binding +namespace: molecular_function +def: "Binding to an unprocessed 5S ribosomal RNA transcript." [GOC:jl] +is_a: GO:0008097 ! 5S rRNA binding + +[Term] +id: GO:0008100 +name: obsolete lipophorin +namespace: molecular_function +def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "lipophorin" EXACT [] +is_obsolete: true +replaced_by: GO:0005319 + +[Term] +id: GO:0008103 +name: oocyte microtubule cytoskeleton polarization +namespace: biological_process +alt_id: GO:0048129 +def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007309 ! oocyte axis specification +relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization + +[Term] +id: GO:0008104 +name: protein localization +namespace: biological_process +alt_id: GO:0008105 +def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] +subset: goslim_drosophila +synonym: "asymmetric protein localisation" RELATED [GOC:mah] +synonym: "asymmetric protein localization" RELATED [] +synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] +synonym: "establishment and maintenance of protein localization" RELATED [] +synonym: "protein localisation" EXACT [GOC:mah] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0008106 +name: alcohol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] +synonym: "alcohol:NADP dehydrogenase activity" EXACT [] +synonym: "aldehyde reductase (NADPH) activity" RELATED [EC:1.1.1.2] +synonym: "aldehyde reductase (NADPH2) activity" EXACT [] +synonym: "NADP-aldehyde reductase activity" EXACT [] +xref: EC:1.1.1.2 +xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:15937 +is_a: GO:0004033 ! aldo-keto reductase (NADP) activity + +[Term] +id: GO:0008107 +name: galactoside 2-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69, RHEA:50664] +synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] +synonym: "alpha-(1->2)-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "alpha-2-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "alpha-2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "galactoside 2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "GDP fucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "GDP-L-fucose:lactose fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69] +synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] +synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" RELATED [EC:2.4.1.69] +xref: EC:2.4.1.69 +xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-9036987 "FUT2 transfers Fuc to Type 1 chains to form H antigen-sec" +xref: Reactome:R-HSA-9603982 "FUT2 transfers Fuc to LeA to form LeB" +xref: Reactome:R-HSA-9603983 "FUT2 transfers Fuc to LeX to form LeY" +xref: RHEA:50664 +is_a: GO:0031127 ! alpha-(1,2)-fucosyltransferase activity + +[Term] +id: GO:0008108 +name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989] +synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] +synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] +synonym: "hexose 1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.12] +synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] +synonym: "uridyltransferase activity" BROAD [EC:2.7.7.12] +synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] +xref: EC:2.7.7.12 +xref: KEGG_REACTION:R00955 +xref: MetaCyc:GALACTURIDYLYLTRANS-RXN +xref: Reactome:R-HSA-5610038 "Defective GALT does not transfer UMP to Gal1P" +xref: Reactome:R-HSA-70361 "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal" +xref: RHEA:13989 +is_a: GO:0070569 ! uridylyltransferase activity + +[Term] +id: GO:0008109 +name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] +synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150] +synonym: "N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150] +synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" RELATED [EC:2.4.1.150] +synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.150] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.150] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] +xref: EC:2.4.1.150 +xref: MetaCyc:2.4.1.150-RXN +xref: RHEA:17413 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008110 +name: L-histidine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16565] +synonym: "histidine aminotransferase activity" BROAD [] +synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38] +synonym: "histidine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.38] +xref: EC:2.6.1.38 +xref: KEGG_REACTION:R01161 +xref: MetaCyc:HISTTRANSAM-RXN +xref: RHEA:16565 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008111 +name: alpha-methylacyl-CoA racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] +synonym: "2-methylacyl-CoA 2-epimerase activity" RELATED [EC:5.1.99.4] +xref: EC:5.1.99.4 +xref: MetaCyc:5.1.99.4-RXN +xref: Reactome:R-HSA-192056 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA" +xref: Reactome:R-HSA-193452 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA" +xref: Reactome:R-HSA-193736 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" +xref: Reactome:R-HSA-193763 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" +xref: Reactome:R-HSA-389897 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA" +xref: RHEA:12657 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0008112 +name: nicotinamide N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23884] +synonym: "nicotinamide methyltransferase activity" RELATED [EC:2.1.1.1] +synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" RELATED [EC:2.1.1.1] +xref: EC:2.1.1.1 +xref: KEGG_REACTION:R01269 +xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-5359451 "NNMT transfers CH3 from SAM to NAM to form MNA" +xref: RHEA:23884 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008113 +name: peptide-methionine (S)-S-oxide reductase activity +namespace: molecular_function +alt_id: GO:0033742 +alt_id: GO:0072561 +def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] +synonym: "methionine S-oxide reductase (S-form oxidizing) activity" RELATED [EC:1.8.4.11] +synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] +synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] +synonym: "methionine sulfoxide reductase A activity" RELATED [EC:1.8.4.11] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] +synonym: "methionine sulphoxide reductase A activity" RELATED [EC:1.8.4.11] +synonym: "MsrA" RELATED [EC:1.8.4.11] +synonym: "peptide Met(O) reductase activity" RELATED [EC:1.8.4.11] +synonym: "peptide methionine sulfoxide reductase activity" RELATED [EC:1.8.4.11] +synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" RELATED [EC:1.8.4.11] +synonym: "peptide-methionine-(S)-S-oxide reductase activity" EXACT [] +synonym: "protein-methionine-S-oxide reductase activity" EXACT [] +xref: EC:1.8.4.11 +xref: MetaCyc:RXN-8668 +xref: MetaCyc:RXN-8669 +xref: Reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides" +xref: Reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine" +xref: RHEA:14217 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0008114 +name: phosphogluconate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] +synonym: "2-keto-6-phosphogluconate reductase activity" RELATED [EC:1.1.1.43] +synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.43] +synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] +synonym: "6-phosphogluconate dehydrogenase (NAD)" RELATED [EC:1.1.1.43] +synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] +synonym: "gluconate 6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.43] +synonym: "phosphogluconate dehydrogenase activity" RELATED [EC:1.1.1.43] +xref: EC:1.1.1.43 +xref: MetaCyc:1.1.1.43-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008115 +name: sarcosine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2)." [EC:1.5.3.1, RHEA:13313] +synonym: "sarcosine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.1] +xref: EC:1.5.3.1 +xref: KEGG_REACTION:R00610 +xref: MetaCyc:SARCOX-RXN +xref: RHEA:13313 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0008116 +name: prostaglandin-I synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23580] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" RELATED [EC:5.3.99.4] +synonym: "cytochrome P450 CYP8A1" NARROW [] +synonym: "PGI(2) synthase activity" RELATED [EC:5.3.99.4] +synonym: "PGI(2) synthetase activity" RELATED [EC:5.3.99.4] +synonym: "PGI2 synthase activity" RELATED [EC:5.3.99.4] +synonym: "PGI2 synthetase activity" RELATED [EC:5.3.99.4] +synonym: "prostacyclin synthase activity" RELATED [EC:5.3.99.4] +synonym: "prostacycline synthetase activity" RELATED [EC:5.3.99.4] +synonym: "prostagladin I2 synthetase activity" RELATED [EC:5.3.99.4] +xref: EC:5.3.99.4 +xref: KEGG_REACTION:R02267 +xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN +xref: Reactome:R-HSA-76496 "PTGIS, CYP8A1 isomerise PGH2 to PGI2" +xref: RHEA:23580 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0008117 +name: sphinganine-1-phosphate aldolase activity +namespace: molecular_function +alt_id: GO:0016001 +def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] +synonym: "dihydrosphingosine 1-phosphate aldolase activity" RELATED [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate alkanal-lyase activity" RELATED [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate lyase activity" RELATED [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" RELATED [EC:4.1.2.27] +synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" RELATED [EC:4.1.2.27] +synonym: "sphingosine-1-phosphate aldolase activity" RELATED [EC:4.1.2.27] +synonym: "sphingosine-1-phosphate lyase activity" RELATED [EC:4.1.2.27] +xref: EC:4.1.2.27 +xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN +xref: Reactome:R-HSA-428676 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal" +xref: Reactome:R-HSA-428681 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal" +xref: RHEA:18593 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008118 +name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6, RHEA:52316] +synonym: "alpha2->3 sialyltransferase activity" RELATED [EC:2.4.99.6] +synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.6] +synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" RELATED [EC:2.4.99.6] +synonym: "SiaT" RELATED [EC:2.4.99.6] +xref: EC:2.4.99.6 +xref: MetaCyc:2.4.99.6-RXN +xref: RHEA:52316 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0008119 +name: thiopurine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] +synonym: "6-thiopurine transmethylase activity" RELATED [EC:2.1.1.67] +synonym: "mercaptopurine methyltransferase activity" RELATED [EC:2.1.1.67] +synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" RELATED [EC:2.1.1.67] +synonym: "thiopurine methyltransferase activity" RELATED [EC:2.1.1.67] +synonym: "TPMT" RELATED [EC:2.1.1.67] +xref: EC:2.1.1.67 +xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP" +xref: Reactome:R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP" +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008120 +name: ceramide glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] +synonym: "ceramide:UDP-glucose glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "ceramide:UDPGlc glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "glucosylceramide synthase activity" RELATED [EC:2.4.1.80] +synonym: "UDP-glucose-ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "UDP-glucose:ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" RELATED [EC:2.4.1.80] +synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" RELATED [EC:2.4.1.80] +xref: EC:2.4.1.80 +xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-1638104 "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide" +xref: RHEA:12088 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008121 +name: ubiquinol-cytochrome-c reductase activity +namespace: molecular_function +alt_id: GO:0045153 +alt_id: GO:0045154 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [RHEA:11484] +synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:7.1.1.8] +synonym: "cytochrome" BROAD [] +synonym: "cytochrome a" NARROW [] +synonym: "cytochrome a3/copper complex" NARROW [] +synonym: "cytochrome b562" NARROW [] +synonym: "cytochrome b566" NARROW [] +synonym: "cytochrome c1" NARROW [] +synonym: "electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity" RELATED [] +synonym: "electron transporter, transferring electrons within cytochrome c oxidase complex activity" RELATED [] +synonym: "mitochondrial electron transport complex III" RELATED [] +synonym: "soluble cytochrome b562" NARROW [] +synonym: "ubiquinol-cytochrome c oxidoreductase activity" RELATED [] +synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" RELATED [] +synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" RELATED [] +synonym: "ubiquinol-cytochrome c2 reductase activity" RELATED [] +synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" RELATED [] +synonym: "ubiquinone--cytochrome-c oxidoreductase activity" RELATED [EC:7.1.1.8] +synonym: "ubiquinone-cytochrome c oxidoreductase activity" RELATED [EC:7.1.1.8] +synonym: "ubiquinone-cytochrome c reductase activity" RELATED [EC:7.1.1.8] +xref: EC:7.1.1.8 +xref: MetaCyc:1.10.2.2-RXN +xref: Reactome:R-HSA-164651 "Electron transfer from ubiquinol to cytochrome c of complex III" +xref: RHEA:11484 +is_a: GO:0009055 ! electron transfer activity +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0008123 +name: cholesterol 7-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.14.23] +synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] +synonym: "cholesterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.23] +synonym: "cholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.23] +synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" RELATED [EC:1.14.14.23] +synonym: "cytochrome P450 CYP7A1" NARROW [] +xref: EC:1.14.14.23 +xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-192051 "CYP7A1 7-hydroxylates CHOL" +xref: RHEA:21812 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008124 +name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11920] +synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] +synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED [EC:4.2.1.96] +synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] +synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" RELATED [EC:4.2.1.96] +synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" RELATED [EC:4.2.1.96] +synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] +synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] +synonym: "pterin-4alpha-carbinolamine dehydratase activity" RELATED [] +synonym: "tetrahydrobiopterin dehydratase activity" RELATED [EC:4.2.1.96] +xref: EC:4.2.1.96 +xref: KEGG_REACTION:R04734 +xref: MetaCyc:RXN-7908 +xref: Reactome:R-HSA-71146 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O" +xref: RHEA:11920 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008125 +name: obsolete pancreatic elastase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "elaszym" RELATED [] +synonym: "pancreatic elastase I activity" EXACT [] +synonym: "pancreatopeptidase E activity" RELATED [] +synonym: "serine elastase" BROAD [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008126 +name: acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] +synonym: "acetic ester hydrolase activity" RELATED [EC:3.1.1.6] +synonym: "acetic-ester acetylhydrolase activity" RELATED [EC:3.1.1.6] +synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] +synonym: "chloroesterase" NARROW [EC:3.1.1.6] +synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] +synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] +xref: EC:3.1.1.6 +xref: MetaCyc:ACETYLESTERASE-RXN +xref: RHEA:12957 +xref: UM-BBD_reactionID:r0170 +is_a: GO:0034338 ! short-chain carboxylesterase activity + +[Term] +id: GO:0008127 +name: quercetin 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15381] +synonym: "flavonol 2,4-oxygenase activity" RELATED [EC:1.13.11.24] +synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.24] +synonym: "quercetinase activity" RELATED [EC:1.13.11.24] +xref: EC:1.13.11.24 +xref: KEGG_REACTION:R02156 +xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN +xref: Reactome:R-HSA-8953398 "PIR oxygenates quercetin" +xref: RHEA:15381 +xref: UM-BBD_reactionID:r0891 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0008129 +name: obsolete actinidain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] +comment: This term was made obsolete because it represents a gene product. +synonym: "actinidain activity" EXACT [] +synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] +synonym: "actinidin activity" RELATED [EC:3.4.22.14] +synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0008130 +name: obsolete neutrophil collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 8 activity" RELATED [] +synonym: "MMP-8" EXACT [] +synonym: "neutrophil collagenase activity" EXACT [] +synonym: "PMNL collagenase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008131 +name: primary amine oxidase activity +namespace: molecular_function +alt_id: GO:0004041 +alt_id: GO:0008122 +def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21] +synonym: "amine oxidase (copper-containing) activity" NARROW [] +synonym: "amine oxidase activity" BROAD [EC:1.4.3.21] +synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21] +xref: EC:1.4.3.21 +xref: KEGG_REACTION:R01853 +xref: MetaCyc:RXN-9597 +xref: Reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT" +xref: Reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA" +xref: Reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR" +xref: Reactome:R-HSA-374909 "Metabolism of Noradrenaline" +xref: Reactome:R-HSA-379382 "MAOA:FAD deaminates DA to DOPAC" +xref: Reactome:R-HSA-379395 "MAOA:FAD deaminates 3MT to HVA" +xref: Reactome:R-HSA-5603108 "Defective MAOA does not oxidatively deaminate 5HT" +xref: Reactome:R-HSA-5696146 "AOC2 deaminates TYR" +xref: Reactome:R-HSA-5696183 "AOC3 deaminates BZAM" +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0008132 +name: obsolete pancreatic elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "pancreatic elastase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008133 +name: obsolete collagenase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "collagenase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008134 +name: transcription factor binding +namespace: molecular_function +def: "Binding to a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] +comment: Note that this term should not be used for direct annotation. Please consier one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding. +subset: gocheck_do_not_annotate +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_yeast +synonym: "TF binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008135 +name: translation factor activity, RNA binding +namespace: molecular_function +def: "Functions during translation by binding to RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] +subset: goslim_chembl +subset: goslim_plant +subset: goslim_yeast +synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah] +is_a: GO:0003723 ! RNA binding +is_a: GO:0090079 ! translation regulator activity, nucleic acid binding + +[Term] +id: GO:0008137 +name: NADH dehydrogenase (ubiquinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out)." [RHEA:29091] +synonym: "coenzyme Q reductase activity" RELATED [EC:7.1.1.2] +synonym: "complex 1 dehydrogenase activity" RELATED [EC:7.1.1.2] +synonym: "complex I (electron transport chain) activity" RELATED [EC:7.1.1.2] +synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:7.1.1.2] +synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:7.1.1.2] +synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" RELATED [EC:7.1.1.2] +synonym: "DPNH-coenzyme Q reductase activity" RELATED [EC:7.1.1.2] +synonym: "DPNH-ubiquinone reductase activity" RELATED [EC:7.1.1.2] +synonym: "electron transfer complex I activity" RELATED [EC:7.1.1.2] +synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:7.1.1.2] +synonym: "mitochondrial electron transport complex I activity" NARROW [EC:7.1.1.2] +synonym: "NADH coenzyme Q1 reductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-coenzyme Q oxidoreductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-coenzyme Q reductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-CoQ oxidoreductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-CoQ reductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-Q6 oxidoreductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-ubiquinone oxidoreductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-ubiquinone reductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH-ubiquinone-1 reductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH:ubiquinone oxidoreductase activity" RELATED [EC:7.1.1.2] +synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:7.1.1.2] +synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" RELATED [EC:7.1.1.2] +synonym: "type 1 dehydrogenase activity" RELATED [EC:7.1.1.2] +synonym: "ubiquinone reductase activity" EXACT [] +xref: EC:7.1.1.2 +xref: MetaCyc:NADH-DEHYDROG-A-RXN +xref: MetaCyc:RXN0-5330 +xref: Reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to QH2" +xref: RHEA:29091 +is_a: GO:0009055 ! electron transfer activity +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity + +[Term] +id: GO:0008138 +name: protein tyrosine/serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] +comment: Note that this term applies only to free amino acids. Consider 'protein serine/threonine phosphatase activity' or 'protein tyrosine/serine/threonine phosphatase activity' if you want to annotate a protein phosphatase. +synonym: "dual-specificity protein phosphatase" BROAD [] +xref: Reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs" +xref: Reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs" +xref: Reactome:R-HSA-9652816 "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs" +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0008139 +name: nuclear localization sequence binding +namespace: molecular_function +def: "Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] +synonym: "NLS binding" EXACT [] +synonym: "nuclear localisation sequence binding" EXACT [GOC:mah] +synonym: "nuclear localization signal binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0008140 +name: cAMP response element binding protein binding +namespace: molecular_function +def: "Binding to a cAMP response element binding protein (a CREB protein)." [GOC:mah] +synonym: "3',5' cAMP response element binding protein binding" EXACT [] +synonym: "3',5'-cAMP response element binding protein binding" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] +synonym: "CBP" RELATED [GOC:bf] +synonym: "CREB binding" EXACT [] +synonym: "cyclic AMP response element binding protein binding" EXACT [] +is_a: GO:0140297 ! DNA-binding transcription factor binding + +[Term] +id: GO:0008141 +name: obsolete puparial glue (sensu Diptera) +namespace: molecular_function +def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "puparial glue (sensu Diptera)" EXACT [] +is_obsolete: true +consider: GO:0005198 +consider: GO:0007594 + +[Term] +id: GO:0008142 +name: oxysterol binding +namespace: molecular_function +def: "Binding to oxysterol, an oxidized form of cholesterol." [GOC:curators] +is_a: GO:0032934 ! sterol binding + +[Term] +id: GO:0008143 +name: poly(A) binding +namespace: molecular_function +def: "Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] +synonym: "poly(A) binding, within an RNA molecule" EXACT [] +synonym: "poly(rA) binding" EXACT [GOC:mah] +synonym: "poly-A binding" EXACT [GOC:mah] +synonym: "polyadenylate binding" EXACT [GOC:mah] +is_a: GO:0070717 ! poly-purine tract binding + +[Term] +id: GO:0008144 +name: obsolete drug binding +namespace: molecular_function +def: "OBSOLETE. Binding to a drug, a naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism;typically used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] +comment: It is not meaningful to describe a molecular function by what role a compound may be used for at some times. +is_obsolete: true + +[Term] +id: GO:0008145 +name: phenylalkylamine binding +namespace: molecular_function +def: "Binding to phenylalkylamine or one of its derivatives." [GOC:jl] +is_a: GO:0043176 ! amine binding + +[Term] +id: GO:0008146 +name: sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [GOC:curators] +subset: goslim_chembl +synonym: "sulphotransferase activity" EXACT [] +xref: EC:2.8.2.- +xref: Reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP" +xref: Reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP" +xref: Reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP" +xref: Reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate" +is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups + +[Term] +id: GO:0008147 +name: structural constituent of bone +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008148 +name: obsolete negative transcription elongation factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "negative transcription elongation factor activity" EXACT [] +is_obsolete: true +consider: GO:0032785 + +[Term] +id: GO:0008149 +name: obsolete para-aminobenzoic acid (PABA) synthase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] +comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. +synonym: "para-aminobenzoic acid (PABA) synthase" EXACT [] +is_obsolete: true +consider: GO:0008696 +consider: GO:0046820 + +[Term] +id: GO:0008150 +name: biological_process +namespace: biological_process +alt_id: GO:0000004 +alt_id: GO:0007582 +alt_id: GO:0044699 +def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] +comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_pombe +subset: goslim_yeast +synonym: "biological process" EXACT [] +synonym: "physiological process" EXACT [] +synonym: "single organism process" RELATED [] +synonym: "single-organism process" RELATED [] +xref: Wikipedia:Biological_process + +[Term] +id: GO:0008152 +name: metabolic process +namespace: biological_process +alt_id: GO:0044236 +alt_id: GO:0044710 +def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] +comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. +subset: gocheck_do_not_manually_annotate +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "metabolic process resulting in cell growth" NARROW [] +synonym: "metabolism" EXACT [] +synonym: "metabolism resulting in cell growth" NARROW [] +synonym: "multicellular organism metabolic process" NARROW [] +synonym: "single-organism metabolic process" RELATED [] +xref: Wikipedia:Metabolism +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0008153 +name: para-aminobenzoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] +synonym: "4-aminobenzoic acid biosynthesis" EXACT [] +synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] +synonym: "p-aminobenzoic acid biosynthesis" EXACT [] +synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] +synonym: "PABA biosynthesis" EXACT [] +synonym: "PABA biosynthetic process" EXACT [] +synonym: "para-aminobenzoic acid anabolism" EXACT [] +synonym: "para-aminobenzoic acid biosynthesis" EXACT [] +synonym: "para-aminobenzoic acid formation" EXACT [] +synonym: "para-aminobenzoic acid synthesis" EXACT [] +synonym: "vitamin Bx biosynthesis" EXACT [] +synonym: "vitamin Bx biosynthetic process" EXACT [] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process +is_a: GO:0046482 ! para-aminobenzoic acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0008154 +name: actin polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0008155 +name: obsolete larval behavior (sensu Drosophila) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. +synonym: "larval behavior (sensu Drosophila)" EXACT [] +is_obsolete: true +replaced_by: GO:0030537 + +[Term] +id: GO:0008156 +name: negative regulation of DNA replication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] +synonym: "DNA replication inhibitor" RELATED [] +synonym: "down regulation of DNA replication" EXACT [] +synonym: "down-regulation of DNA replication" EXACT [] +synonym: "downregulation of DNA replication" EXACT [] +synonym: "inhibition of DNA replication" NARROW [] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0008157 +name: protein phosphatase 1 binding +namespace: molecular_function +def: "Binding to a protein phosphatase 1." [GOC:jl] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0008158 +name: hedgehog receptor activity +namespace: molecular_function +def: "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137] +synonym: "patched activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0008159 +name: obsolete positive transcription elongation factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "positive transcription elongation factor activity" EXACT [] +is_obsolete: true +consider: GO:0032786 + +[Term] +id: GO:0008160 +name: protein tyrosine phosphatase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732] +is_a: GO:0072542 ! protein phosphatase activator activity + +[Term] +id: GO:0008161 +name: obsolete carbamate resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "carbamate resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046681 + +[Term] +id: GO:0008162 +name: obsolete cyclodiene resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "cyclodiene resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046682 + +[Term] +id: GO:0008163 +name: obsolete DDT resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "DDT resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046680 + +[Term] +id: GO:0008164 +name: obsolete organophosphorus resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "organophosphorus resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046683 + +[Term] +id: GO:0008165 +name: obsolete pyrethroid resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "pyrethroid resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046684 + +[Term] +id: GO:0008166 +name: obsolete viral replication +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. +synonym: "viral replication" EXACT [] +is_obsolete: true +consider: GO:0019079 + +[Term] +id: GO:0008167 +name: obsolete sigma virus replication +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +synonym: "sigma virus replication" EXACT [] +is_obsolete: true +replaced_by: GO:0019079 + +[Term] +id: GO:0008168 +name: methyltransferase activity +namespace: molecular_function +alt_id: GO:0004480 +def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "methylase" BROAD [] +xref: EC:2.1.1.- +xref: Reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" +xref: Reactome:R-HSA-379387 "COMT transfers Met to DA to form 3MT" +xref: Reactome:R-HSA-379464 "COMT transfers Met to DOPAC to form HVA" +xref: Reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII" +xref: Reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine" +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0008169 +name: C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008170 +name: N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008171 +name: O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] +xref: EC:2.1.1.- +xref: Reactome:R-HSA-5578717 "BCDIN3D dimethylates 5' phosphate of pre-miR-145" +xref: Reactome:R-HSA-5629203 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH" +xref: Reactome:R-HSA-5629218 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1" +xref: Reactome:R-HSA-5629237 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH" +xref: Reactome:R-HSA-6790907 "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008172 +name: S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] +xref: EC:2.1.1.- +xref: Reactome:R-HSA-209821 "Methylation of N-acetyl-5-HT to form melatonin" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008173 +name: RNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] +comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). +xref: Reactome:R-HSA-191784 "snRNA Cap hypermethylation" +is_a: GO:0008168 ! methyltransferase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0008174 +name: mRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008175 +name: tRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] +xref: Reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)" +xref: Reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)" +xref: Reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)" +xref: Reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)" +xref: Reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34" +xref: Reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine" +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0008176 +name: tRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] +synonym: "7-methylguanine transfer ribonucleate methylase activity" RELATED [EC:2.1.1.33] +synonym: "N7-methylguanine methylase activity" RELATED [EC:2.1.1.33] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" RELATED [EC:2.1.1.33] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" RELATED [EC:2.1.1.33] +synonym: "transfer ribonucleate guanine 7-methyltransferase activity" RELATED [EC:2.1.1.33] +synonym: "tRNA guanine 7-methyltransferase activity" RELATED [EC:2.1.1.33] +xref: EC:2.1.1.33 +xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46" +xref: RHEA:42708 +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008177 +name: succinate dehydrogenase (ubiquinone) activity +namespace: molecular_function +alt_id: GO:0019737 +def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [RHEA:13713] +synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] +synonym: "menaquinol: fumarate oxidoreductase activity" RELATED [EC:1.3.5.1] +synonym: "quinol:fumarate oxidoreductase activity" EXACT [] +synonym: "respiratory complex II" RELATED [EC:1.3.5.1] +synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] +synonym: "succinate:ubiquinone oxidoreductase activity" RELATED [EC:1.3.5.1] +synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] +xref: EC:1.3.5.1 +xref: KEGG_REACTION:R02164 +xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN +xref: Reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex" +xref: Reactome:R-HSA-70994 "Succinate <=> Fumarate (with FAD redox reaction on enzyme)" +xref: RHEA:13713 +is_a: GO:0000104 ! succinate dehydrogenase activity +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0008179 +name: adenylate cyclase binding +namespace: molecular_function +def: "Binding to an adenylate cyclase." [GOC:jl] +synonym: "adenylyl cyclase binding" EXACT [] +xref: Reactome:R-HSA-170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it" +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0008180 +name: COP9 signalosome +namespace: cellular_component +def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] +synonym: "COP9 complex" EXACT [GOC:krc] +synonym: "CSN" EXACT [] +synonym: "signalosome" BROAD [GOC:krc] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0008181 +name: obsolete tumor suppressor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. +synonym: "tumor suppressor" EXACT [] +is_obsolete: true +consider: GO:0051726 + +[Term] +id: GO:0008184 +name: glycogen phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] +xref: MetaCyc:GLYCOPHOSPHORYL-RXN +xref: Reactome:R-HSA-453339 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]" +xref: Reactome:R-HSA-453358 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" +xref: Reactome:R-HSA-71515 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" +xref: Reactome:R-HSA-71590 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]" +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0008186 +name: ATP-dependent activity, acting on RNA +namespace: molecular_function +alt_id: GO:0004010 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] +synonym: "ATPase activity, acting on RNA" EXACT [] +synonym: "ATPase, acting on RNA" EXACT [] +synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] +synonym: "RNA-dependent ATPase activity" EXACT [] +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0008187 +name: poly-pyrimidine tract binding +namespace: molecular_function +def: "Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0008188 +name: neuropeptide receptor activity +namespace: molecular_function +def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0008189 +name: obsolete apoptosis inhibitor activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] +comment: This term was made obsolete because it represents involvement in a biological process. +synonym: "apoptosis inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0043066 + +[Term] +id: GO:0008190 +name: eukaryotic initiation factor 4E binding +namespace: molecular_function +def: "Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732] +synonym: "eIF4E binding" EXACT [] +is_a: GO:0031369 ! translation initiation factor binding + +[Term] +id: GO:0008191 +name: metalloendopeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] +synonym: "metalloprotease inhibitor" NARROW [] +synonym: "metalloproteinase inhibitor" NARROW [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0008192 +name: RNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0008193 +name: tRNA guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] +xref: EC:2.7.7.79 +xref: RHEA:54564 +is_a: GO:0008192 ! RNA guanylyltransferase activity + +[Term] +id: GO:0008194 +name: UDP-glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] +xref: Reactome:R-HSA-162730 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP" +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0008195 +name: phosphatidate phosphatase activity +namespace: molecular_function +alt_id: GO:0004606 +def: "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr] +synonym: "3-sn-phosphatidate phosphohydrolase activity" RELATED [EC:3.1.3.4] +synonym: "acid phosphatidyl phosphatase activity" RELATED [EC:3.1.3.4] +synonym: "phosphatic acid phosphatase activity" RELATED [EC:3.1.3.4] +synonym: "phosphatic acid phosphohydrolase activity" RELATED [EC:3.1.3.4] +synonym: "phosphatidate phosphohydrolase activity" EXACT [] +synonym: "phosphatidic acid phosphatase activity" RELATED [EC:3.1.3.4] +xref: EC:3.1.3.4 +xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN +xref: Reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN" +xref: Reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A" +xref: Reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A" +xref: Reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex" +xref: Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 568) by PP2A" +xref: Reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1" +xref: Reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A" +xref: Reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol" +xref: Reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA" +xref: Reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate" +xref: RHEA:27429 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008196 +name: vitellogenin receptor activity +namespace: molecular_function +def: "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis." [GOC:bf, PMID:12429745] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0008197 +name: obsolete yolk protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "yolk protein" EXACT [] +is_obsolete: true +consider: GO:0005198 +consider: GO:0045735 + +[Term] +id: GO:0008198 +name: ferrous iron binding +namespace: molecular_function +def: "Binding to a ferrous iron ion, Fe(II)." [GOC:ai] +is_a: GO:0005506 ! iron ion binding + +[Term] +id: GO:0008199 +name: ferric iron binding +namespace: molecular_function +def: "Binding to a ferric iron ion, Fe(III)." [GOC:ai] +is_a: GO:0005506 ! iron ion binding + +[Term] +id: GO:0008200 +name: ion channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an ion channel." [GOC:mah] +is_a: GO:0016248 ! channel inhibitor activity +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0008201 +name: heparin binding +namespace: molecular_function +def: "Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] +synonym: "heparan sulfate binding" RELATED [] +is_a: GO:0005539 ! glycosaminoglycan binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0008202 +name: steroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] +synonym: "steroid metabolism" EXACT [] +xref: Wikipedia:Steroid_metabolism +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0008203 +name: cholesterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732] +synonym: "cholesterol metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0008204 +name: ergosterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732] +synonym: "ergosterol metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:0016128 ! phytosteroid metabolic process +is_a: GO:0044107 ! cellular alcohol metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0008205 +name: ecdysone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732] +synonym: "ecdysone metabolism" EXACT [] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:0045455 ! ecdysteroid metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0008206 +name: bile acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] +synonym: "bile acid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0008207 +name: C21-steroid hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0008208 +name: C21-steroid hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] +synonym: "C21-steroid hormone breakdown" EXACT [] +synonym: "C21-steroid hormone catabolism" EXACT [] +synonym: "C21-steroid hormone degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0008209 +name: androgen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] +synonym: "androgen metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0008210 +name: estrogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] +synonym: "estrogen metabolism" EXACT [] +synonym: "oestrogen metabolic process" EXACT [] +synonym: "oestrogen metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0008211 +name: glucocorticoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732] +synonym: "glucocorticoid metabolism" EXACT [] +synonym: "glucocorticosteroid metabolic process" EXACT [] +synonym: "glucocorticosteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0008212 +name: mineralocorticoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732] +synonym: "mineralocorticoid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0008213 +name: protein alkylation +namespace: biological_process +def: "The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom." [GOC:ma] +subset: goslim_yeast +synonym: "protein amino acid alkylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0008214 +name: protein dealkylation +namespace: biological_process +def: "The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom." [GOC:ai] +synonym: "protein amino acid dealkylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0008215 +name: spermine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:curators] +synonym: "spermine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0008216 +name: spermidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +synonym: "spermidine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0008217 +name: regulation of blood pressure +namespace: biological_process +def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] +synonym: "blood pressure homeostasis" RELATED [] +synonym: "blood pressure regulation" EXACT [] +synonym: "control of blood pressure" RELATED [] +xref: Wikipedia:Blood_pressure#Regulation +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0008218 +name: bioluminescence +namespace: biological_process +def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] +subset: goslim_chembl +subset: goslim_metagenomics +xref: Wikipedia:Bioluminescence +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0008219 +name: cell death +namespace: biological_process +def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_mouse +subset: goslim_plant +synonym: "accidental cell death" RELATED [] +synonym: "necrosis" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0008220 +name: obsolete necrosis +namespace: biological_process +def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] +comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. +synonym: "necrosis" EXACT [] +is_obsolete: true +consider: GO:0001906 +consider: GO:0008219 +consider: GO:0012501 +consider: GO:0019835 +consider: GO:0070265 + +[Term] +id: GO:0008222 +name: obsolete tumor antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "tumor antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0008224 +name: obsolete Gram-positive antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "Gram-positive antibacterial peptide activity" EXACT [] +is_obsolete: true +consider: GO:0050830 + +[Term] +id: GO:0008225 +name: obsolete Gram-negative antibacterial peptide activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] +comment: This term was made obsolete because it describes involvement in a process and not a function. +synonym: "Gram-negative antibacterial peptide activity" EXACT [] +is_obsolete: true +consider: GO:0050829 + +[Term] +id: GO:0008226 +name: tyramine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [GOC:curators] +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:0008227 +name: G protein-coupled amine receptor activity +namespace: molecular_function +def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] +synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf] +synonym: "biogenic amine receptor" NARROW [] +synonym: "G-protein coupled amine receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0008228 +name: opsonization +namespace: biological_process +def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] +xref: Wikipedia:Opsonin +is_a: GO:0002252 ! immune effector process +relationship: positively_regulates GO:0006910 ! phagocytosis, recognition + +[Term] +id: GO:0008229 +name: obsolete opsonin activity +namespace: molecular_function +def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "opsonin activity" EXACT [] +is_obsolete: true +consider: GO:0003823 + +[Term] +id: GO:0008230 +name: ecdysone receptor holocomplex +namespace: cellular_component +def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0008231 +name: repressor ecdysone receptor complex +namespace: cellular_component +def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] +synonym: "repressor ecdysone receptor holocomplex" RELATED [] +is_a: GO:0008230 ! ecdysone receptor holocomplex + +[Term] +id: GO:0008232 +name: activator ecdysone receptor complex +namespace: cellular_component +def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] +synonym: "activator ecdysone receptor holocomplex" RELATED [] +is_a: GO:0008230 ! ecdysone receptor holocomplex + +[Term] +id: GO:0008233 +name: peptidase activity +namespace: molecular_function +alt_id: GO:0070010 +alt_id: GO:0070011 +def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_yeast +synonym: "hydrolase, acting on peptide bonds" EXACT [] +synonym: "peptidase activity, acting on D-amino acid peptides" NARROW [] +synonym: "peptidase activity, acting on L-amino acid peptides" NARROW [] +synonym: "peptide hydrolase activity" EXACT [] +synonym: "protease activity" EXACT [] +synonym: "proteinase activity" NARROW [] +xref: EC:3.4.-.- +xref: Reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" +xref: Reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" +xref: Reactome:R-HSA-3065958 "An unknown protease degrades ACACA" +xref: Reactome:R-HSA-3065959 "An unknown protease degrades hCBXs" +xref: Reactome:R-HSA-3139027 "Maturation of HIV Virion" +xref: Reactome:R-HSA-376149 "Proteolytic processing of SLIT" +xref: Reactome:R-HSA-4167501 "An unknown protease degrades ACACB" +xref: Reactome:R-HSA-448678 "CTSG cleaves CASP1(1-404)" +xref: Reactome:R-HSA-5655483 "USP1 autocleavage" +xref: Reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" +xref: Reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" +xref: Reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" +xref: Reactome:R-HSA-6803060 "DCD(63-110) is processed to DCD(63-109)" +is_a: GO:0016787 ! hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008234 +name: cysteine-type peptidase activity +namespace: molecular_function +alt_id: GO:0004220 +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +synonym: "cysteine protease activity" NARROW [] +synonym: "thiol protease activity" NARROW [] +xref: Reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" +xref: Reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" +xref: Reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" +xref: Reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0008235 +name: metalloexopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml] +is_a: GO:0008237 ! metallopeptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008236 +name: serine-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +synonym: "serine protease activity" NARROW [] +xref: Reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin" +xref: Reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" +xref: Reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:Cbl" +xref: Reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)" +is_a: GO:0008233 ! peptidase activity +is_a: GO:0017171 ! serine hydrolase activity + +[Term] +id: GO:0008237 +name: metallopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +synonym: "metalloprotease activity" NARROW [GOC:mah] +synonym: "metalloproteinase activity" NARROW [GOC:mah] +xref: Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2" +xref: Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1" +xref: Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain" +xref: Reactome:R-HSA-2022368 "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)" +xref: Reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)" +xref: Reactome:R-HSA-2022396 "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)" +xref: Reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)" +xref: Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants" +xref: Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding" +xref: Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1" +xref: Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding" +xref: Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs" +xref: Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)" +xref: Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)" +xref: Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)" +xref: Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)" +xref: Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)" +xref: Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)" +xref: Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)" +xref: Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3" +xref: Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4" +xref: Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163" +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0008238 +name: exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE] +synonym: "exoprotease activity" NARROW [] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0008239 +name: dipeptidyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE] +xref: EC:3.4.14.1 +xref: EC:3.4.14.2 +xref: EC:3.4.14.4 +xref: EC:3.4.14.5 +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008240 +name: tripeptidyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] +xref: EC:3.4.14.10 +xref: EC:3.4.14.9 +xref: MetaCyc:3.4.14.10-RXN +xref: MetaCyc:3.4.14.9-RXN +is_a: GO:0070008 ! serine-type exopeptidase activity + +[Term] +id: GO:0008241 +name: peptidyl-dipeptidase activity +namespace: molecular_function +def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] +xref: EC:3.4.15.- +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0008242 +name: omega peptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes." [EC:3.4.19.-, PMID:20157488, PMID:9920379] +synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] +xref: EC:3.4.19.- +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0008243 +name: obsolete plasminogen activator activity +namespace: molecular_function +alt_id: GO:0004296 +alt_id: GO:0004297 +def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "abbokinase activity" RELATED [] +synonym: "cellular plasminogen activator activity" NARROW [] +synonym: "double-chain urokinase-type plasminogen activator" RELATED [] +synonym: "plasminogen activator activity" EXACT [] +synonym: "plasminogen activator, tissue-type" RELATED [] +synonym: "t-PA" RELATED [] +synonym: "t-plasminogen activator activity" NARROW [] +synonym: "tissue plasminogen activator activity" NARROW [] +synonym: "tissue-type plasminogen activator activity" RELATED [] +synonym: "tPA activity" NARROW [] +synonym: "two-chain urokinase-type plasminogen activator" RELATED [] +synonym: "u-PA" RELATED [] +synonym: "u-plasminogen activator activity" NARROW [] +synonym: "uPA" RELATED [] +synonym: "urinary esterase A" RELATED [] +synonym: "urinary plasminogen activator activity" NARROW [] +synonym: "urokinase activity" RELATED [] +synonym: "urokinase plasminogen activator" RELATED [] +synonym: "urokinase-type plasminogen activator" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008245 +name: obsolete lysosomal membrane hydrogen-transporting ATPase +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "lysosomal membrane hydrogen-transporting ATPase" EXACT [] +synonym: "V-ATPase" RELATED [] +is_obsolete: true +consider: GO:0046611 + +[Term] +id: GO:0008246 +name: obsolete electron transfer flavoprotein +namespace: molecular_function +def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "electron transfer flavoprotein" EXACT [] +synonym: "ETF" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0008247 +name: 1-alkyl-2-acetylglycerophosphocholine esterase complex +namespace: cellular_component +def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] +comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. +synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT [] +synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0008248 +name: obsolete pre-mRNA splicing factor activity +namespace: molecular_function +def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] +comment: This term was made obsolete because it describes a biological process. +synonym: "pre-mRNA splicing factor activity" EXACT [] +is_obsolete: true +consider: GO:0008380 + +[Term] +id: GO:0008250 +name: oligosaccharyltransferase complex +namespace: cellular_component +def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] +synonym: "oligosaccharyl transferase complex" EXACT [] +synonym: "OST complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0008251 +name: tRNA-specific adenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah] +synonym: "tRNA-adenosine deaminase activity" EXACT [] +xref: Reactome:R-HSA-6782311 "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs" +xref: Reactome:R-HSA-6782336 "ADAT1 deaminates adenosine-37 in tRNA(Ala)" +is_a: GO:0004000 ! adenosine deaminase activity + +[Term] +id: GO:0008252 +name: nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [RHEA:22140] +synonym: "acid nucleotidase activity" RELATED [] +synonym: "deoxyinosine-activated nucleotidase (DIAN)" RELATED [] +synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" RELATED [] +synonym: "NSP I" RELATED [] +synonym: "NSP II" RELATED [] +synonym: "nucleotide phosphohydrolase activity" RELATED [] +synonym: "nucleotide-specific phosphatase activity" RELATED [] +xref: MetaCyc:NUCLEOTIDASE-RXN +xref: RHEA:22140 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008253 +name: 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] +synonym: "5' nucleotidase activity" EXACT [] +synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] +synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] +synonym: "5'-AMPase" NARROW [EC:3.1.3.5] +synonym: "5'-mononucleotidase activity" RELATED [EC:3.1.3.5] +synonym: "5'-ribonucleotide phosphohydrolase activity" RELATED [EC:3.1.3.5] +synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] +synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] +synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] +synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] +synonym: "AMPase" NARROW [EC:3.1.3.5] +synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] +synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] +synonym: "UMPase" NARROW [EC:3.1.3.5] +synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] +xref: EC:3.1.3.5 +xref: MetaCyc:5-NUCLEOTID-RXN +xref: Reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP" +xref: Reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]" +xref: Reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)" +xref: Reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)" +xref: Reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]" +xref: Reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)" +xref: Reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)" +xref: Reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]" +xref: Reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]" +xref: Reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG" +xref: Reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)" +xref: Reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+" +xref: Reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN" +xref: RHEA:12484 +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008254 +name: 3'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] +synonym: "3' nucleotidase activity" EXACT [] +synonym: "3'-mononucleotidase activity" RELATED [EC:3.1.3.6] +synonym: "3'-phosphatase activity" RELATED [EC:3.1.3.6] +synonym: "3'-ribonucleotidase activity" RELATED [EC:3.1.3.6] +synonym: "3'-ribonucleotide phosphohydrolase activity" RELATED [EC:3.1.3.6] +xref: EC:3.1.3.6 +xref: MetaCyc:3-NUCLEOTID-RXN +xref: RHEA:10144 +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008255 +name: ecdysis-triggering hormone activity +namespace: molecular_function +def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0008256 +name: protein histidine pros-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] +synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" RELATED [EC:2.7.13.1] +synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" RELATED [EC:2.7.13.1] +synonym: "HK2" RELATED [EC:2.7.13.1] +synonym: "protein-histidine pros-kinase activity" RELATED [EC:2.7.13.1] +xref: EC:2.7.13.1 +xref: MetaCyc:2.7.13.1-RXN +xref: RHEA:22720 +is_a: GO:0004673 ! protein histidine kinase activity + +[Term] +id: GO:0008257 +name: protein histidine tele-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] +synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" RELATED [EC:2.7.13.2] +synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" RELATED [EC:2.7.13.2] +synonym: "HK3" RELATED [EC:2.7.13.2] +synonym: "protein-histidine tele-kinase activity" RELATED [EC:2.7.13.2] +xref: EC:2.7.13.2 +xref: MetaCyc:2.7.13.2-RXN +xref: RHEA:11860 +is_a: GO:0004673 ! protein histidine kinase activity + +[Term] +id: GO:0008258 +name: head involution +namespace: biological_process +def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:0879694238] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0008259 +name: obsolete transforming growth factor beta ligand binding to type I receptor +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a function. +synonym: "TGF-beta ligand binding to type I receptor" EXACT [] +synonym: "TGFbeta ligand binding to type I receptor" EXACT [] +synonym: "transforming growth factor beta ligand binding to type I receptor" EXACT [] +is_obsolete: true +consider: GO:0005025 +consider: GO:0005160 +consider: GO:0050431 + +[Term] +id: GO:0008260 +name: 3-oxoacid CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] +synonym: "3-ketoacid CoA-transferase activity" RELATED [EC:2.8.3.5] +synonym: "3-ketoacid coenzyme A transferase activity" RELATED [EC:2.8.3.5] +synonym: "3-oxo-CoA transferase activity" RELATED [EC:2.8.3.5] +synonym: "3-oxoacid CoA dehydrogenase activity" RELATED [EC:2.8.3.5] +synonym: "3-oxoacid coenzyme A-transferase activity" RELATED [EC:2.8.3.5] +synonym: "acetoacetate succinyl-CoA transferase activity" RELATED [EC:2.8.3.5] +synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" RELATED [EC:2.8.3.5] +synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" RELATED [EC:2.8.3.5] +synonym: "succinyl-CoA transferase activity" RELATED [EC:2.8.3.5] +synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" RELATED [EC:2.8.3.5] +synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" RELATED [EC:2.8.3.5] +xref: EC:2.8.3.5 +xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN +xref: Reactome:R-HSA-74177 "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA" +xref: RHEA:25480 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008261 +name: allatostatin receptor activity +namespace: molecular_function +def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0008263 +name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] +synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] +is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0008265 +name: Mo-molybdopterin cofactor sulfurase activity +namespace: molecular_function +def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] +synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] +synonym: "molybdopterin cofactor sulfurase activity" EXACT [] +synonym: "molybdopterin synthase sulfurylase activity" EXACT [] +xref: EC:2.8.1.9 +xref: Reactome:R-HSA-947499 "Exchange of oxygen with sulfur in MoCo" +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0008266 +name: poly(U) RNA binding +namespace: molecular_function +def: "Binding to a sequence of uracil residues in an RNA molecule." [GOC:mah] +synonym: "poly(U) binding" EXACT [GOC:mah] +is_a: GO:0008187 ! poly-pyrimidine tract binding + +[Term] +id: GO:0008267 +name: poly-glutamine tract binding +namespace: molecular_function +def: "Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0008268 +name: obsolete receptor signaling protein tyrosine kinase signaling protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. +synonym: "receptor signaling protein tyrosine kinase signaling protein activity" EXACT [] +synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] +is_obsolete: true +consider: GO:0035556 + +[Term] +id: GO:0008269 +name: JAK pathway signal transduction adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +is_a: GO:0035591 ! signaling adaptor activity + +[Term] +id: GO:0008270 +name: zinc ion binding +namespace: molecular_function +def: "Binding to a zinc ion (Zn)." [GOC:ai] +synonym: "zinc binding" EXACT [] +synonym: "Zn binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0008271 +name: secondary active sulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] +synonym: "sulfate porter activity" RELATED [] +synonym: "sulphate porter activity" EXACT [] +is_a: GO:0015116 ! sulfate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0008272 +name: sulfate transport +namespace: biological_process +alt_id: GO:0006870 +def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "sulphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0008273 +name: calcium, potassium:sodium antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] +synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] +xref: Reactome:R-HSA-2514891 "SLC24A1 exchanges 4Na+ for Ca2+, K+" +xref: Reactome:R-HSA-425678 "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+" +xref: Reactome:R-HSA-5625841 "Defective SLC24A1 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+" +xref: Reactome:R-HSA-5626270 "Defective SLC24A4 does not exchange extracellular 4Na+ for cytosolic Ca2+, K+" +xref: Reactome:R-HSA-5626316 "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+" +xref: Reactome:R-HSA-5626356 "Defective SLC24A5 does not exchange cytosolic 4Na+ for Golgi luminal Ca2+, K+" +is_a: GO:0005432 ! calcium:sodium antiporter activity +is_a: GO:0022821 ! potassium ion antiporter activity + +[Term] +id: GO:0008275 +name: gamma-tubulin small complex +namespace: cellular_component +alt_id: GO:0000927 +alt_id: GO:0000928 +alt_id: GO:0061495 +def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] +synonym: "gamma-tubulin small complex, centrosomal" NARROW [] +synonym: "gamma-tubulin small complex, mitotic spindle pole body" NARROW [] +synonym: "gamma-tubulin small complex, spindle pole body" NARROW [] +synonym: "gammaTuSC" EXACT [] +synonym: "Tub4 complex" NARROW [] +is_a: GO:0000930 ! gamma-tubulin complex + +[Term] +id: GO:0008276 +name: protein methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] +xref: Reactome:R-HSA-9632182 "PRMT1 methylates ESRs" +is_a: GO:0008168 ! methyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008277 +name: regulation of G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] +synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "regulation of GPCR protein signaling pathway" EXACT [] +synonym: "regulation of GPCR protein signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0008278 +name: cohesin complex +namespace: cellular_component +alt_id: GO:0008279 +alt_id: GO:0008280 +alt_id: GO:0043222 +def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095] +subset: goslim_pir +synonym: "14S cohesin" NARROW [] +synonym: "9S cohesin" NARROW [] +synonym: "cohesin core heterodimer" RELATED [] +synonym: "SMC complex" RELATED [] +synonym: "SMC/kleisin ring complex" EXACT [] +synonym: "Smc1-Smc3 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0008281 +name: sulfonylurea receptor activity +namespace: molecular_function +def: "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. +synonym: "sulphonylurea receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0008282 +name: inward rectifying potassium channel +namespace: cellular_component +def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity." [GOC:bhm, PMID:16308567, PMID:16956886] +synonym: "ATP-sensitive potassium channel complex" EXACT [] +synonym: "inward rectifying K+ channel" EXACT [] +synonym: "KCNJ11-SUR complex" RELATED [] +synonym: "KCNJ11-SURx complex" RELATED [] +synonym: "KCNJ8-SUR complex" RELATED [] +synonym: "KCNJ8-SURx complex" RELATED [] +synonym: "Kir6-SUR complex" RELATED [] +synonym: "Kir6.1-SUR complex" RELATED [] +synonym: "Kir6.1-SURx complex" RELATED [] +synonym: "Kir6.2-SUR complex" RELATED [] +synonym: "Kir6.2-SURx complex" RELATED [] +synonym: "Kir6.x complex" RELATED [] +synonym: "Kir6.x-SURx complex" RELATED [] +is_a: GO:0034705 ! potassium channel complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0008283 +name: cell population proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] +comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +synonym: "cell proliferation" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0008284 +name: positive regulation of cell population proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] +synonym: "activation of cell proliferation" NARROW [] +synonym: "positive regulation of cell proliferation" RELATED [] +synonym: "stimulation of cell proliferation" NARROW [] +synonym: "up regulation of cell proliferation" EXACT [] +synonym: "up-regulation of cell proliferation" EXACT [] +synonym: "upregulation of cell proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0008283 ! cell population proliferation + +[Term] +id: GO:0008285 +name: negative regulation of cell population proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] +synonym: "down regulation of cell proliferation" EXACT [] +synonym: "down-regulation of cell proliferation" EXACT [] +synonym: "downregulation of cell proliferation" EXACT [] +synonym: "inhibition of cell proliferation" NARROW [] +synonym: "negative regulation of cell proliferation" RELATED [] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0008283 ! cell population proliferation + +[Term] +id: GO:0008286 +name: insulin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] +synonym: "daf-2 receptor signaling pathway" NARROW [] +synonym: "insulin receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0032869 ! cellular response to insulin stimulus + +[Term] +id: GO:0008287 +name: protein serine/threonine phosphatase complex +namespace: cellular_component +def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] +subset: goslim_pir +is_a: GO:1903293 ! phosphatase complex + +[Term] +id: GO:0008288 +name: boss receptor activity +namespace: molecular_function +def: "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:jl, GOC:signaling] +synonym: "sevenless receptor activity" RELATED [] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0008289 +name: lipid binding +namespace: molecular_function +def: "Binding to a lipid." [GOC:ai] +subset: goslim_agr +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008290 +name: F-actin capping protein complex +namespace: cellular_component +def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0008291 +name: acetylcholine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] +synonym: "acetylcholine metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:1900619 ! acetate ester metabolic process + +[Term] +id: GO:0008292 +name: acetylcholine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] +synonym: "acetylcholine anabolism" EXACT [] +synonym: "acetylcholine biosynthesis" EXACT [] +synonym: "acetylcholine formation" EXACT [] +synonym: "acetylcholine synthesis" EXACT [] +is_a: GO:0008291 ! acetylcholine metabolic process +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process + +[Term] +id: GO:0008293 +name: torso signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] +synonym: "torso signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0008294 +name: calcium- and calmodulin-responsive adenylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] +synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] +synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] +xref: Reactome:R-HSA-111930 "Adenylate cyclase produces cAMP" +xref: Reactome:R-HSA-442715 "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP" +is_a: GO:0004016 ! adenylate cyclase activity + +[Term] +id: GO:0008295 +name: spermidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732] +synonym: "spermidine anabolism" EXACT [] +synonym: "spermidine biosynthesis" EXACT [] +synonym: "spermidine formation" EXACT [] +synonym: "spermidine synthesis" EXACT [] +xref: MetaCyc:BSUBPOLYAMSYN-PWY +xref: MetaCyc:POLYAMINSYN3-PWY +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0008296 +name: 3'-5'-exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] +synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] +xref: Reactome:R-HSA-9023943 "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end" +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008297 +name: single-stranded DNA exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] +synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED [] +synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah] +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008298 +name: intracellular mRNA localization +namespace: biological_process +def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] +synonym: "intracellular mRNA localisation" EXACT [GOC:mah] +synonym: "intracellular mRNA positioning" NARROW [] +synonym: "mRNA localization, intracellular" EXACT [] +synonym: "mRNA positioning, intracellular" NARROW [] +is_a: GO:0006403 ! RNA localization +is_a: GO:0070727 ! cellular macromolecule localization + +[Term] +id: GO:0008299 +name: isoprenoid biosynthetic process +namespace: biological_process +alt_id: GO:0009241 +def: "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] +synonym: "isoprenoid anabolism" EXACT [] +synonym: "isoprenoid biosynthesis" EXACT [] +synonym: "isoprenoid formation" EXACT [] +synonym: "isoprenoid synthesis" EXACT [] +synonym: "polyisoprenoid anabolism" NARROW [] +synonym: "polyisoprenoid biosynthesis" NARROW [] +synonym: "polyisoprenoid biosynthetic process" NARROW [] +synonym: "polyisoprenoid formation" NARROW [] +synonym: "polyisoprenoid synthesis" NARROW [] +synonym: "polyterpene biosynthesis" NARROW [] +synonym: "polyterpene biosynthetic process" NARROW [] +xref: MetaCyc:POLYISOPRENSYN-PWY +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0008300 +name: isoprenoid catabolic process +namespace: biological_process +alt_id: GO:0016097 +def: "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] +synonym: "isoprenoid breakdown" EXACT [] +synonym: "isoprenoid catabolism" EXACT [] +synonym: "isoprenoid degradation" EXACT [] +synonym: "polyisoprenoid breakdown" NARROW [] +synonym: "polyisoprenoid catabolic process" NARROW [] +synonym: "polyisoprenoid catabolism" NARROW [] +synonym: "polyisoprenoid degradation" NARROW [] +synonym: "polyterpene catabolic process" NARROW [] +synonym: "polyterpene catabolism" NARROW [] +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0008301 +name: DNA binding, bending +namespace: molecular_function +def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] +synonym: "DNA bending activity" EXACT [] +synonym: "DNA bending involving DNA binding" EXACT [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0008302 +name: female germline ring canal formation, actin assembly +namespace: biological_process +def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] +synonym: "nurse cell ring canal formation, actin assembly" NARROW [] +synonym: "ovarian ring canal formation, actin assembly" NARROW [] +synonym: "ring canal formation, actin assembly" BROAD [] +is_a: GO:0007015 ! actin filament organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007301 ! female germline ring canal formation + +[Term] +id: GO:0008303 +name: caspase complex +namespace: cellular_component +def: "A protein complex that contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes." [GOC:cna, GOC:mtg_apoptosis, PMID:15569692] +comment: Note that this term was reinstated from obsolete. +synonym: "cysteine-type endopeptidase complex" EXACT [GOC:pr] +is_a: GO:1905369 ! endopeptidase complex + +[Term] +id: GO:0008304 +name: obsolete eukaryotic translation initiation factor 4 complex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "eIF-4" EXACT [] +synonym: "eukaryotic translation initiation factor 4 complex" EXACT [] +is_obsolete: true +replaced_by: GO:0016281 + +[Term] +id: GO:0008305 +name: integrin complex +namespace: cellular_component +def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] +synonym: "laminin receptor protein" RELATED [] +is_a: GO:0098636 ! protein complex involved in cell adhesion +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0008306 +name: associative learning +namespace: biological_process +def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] +synonym: "classical conditioning" EXACT [] +synonym: "conditional learning" EXACT [] +synonym: "conditional response" EXACT [] +synonym: "Pavlovian conditioning" EXACT [] +xref: Wikipedia:Learning#Associative_learning +is_a: GO:0007612 ! learning + +[Term] +id: GO:0008307 +name: structural constituent of muscle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008308 +name: voltage-gated anion channel activity +namespace: molecular_function +alt_id: GO:0022844 +def: "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729] +synonym: "voltage-dependent ion-selective channel activity" RELATED [] +synonym: "voltage-gated ion-selective channel activity" RELATED [] +xref: Reactome:R-HSA-9012374 "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space" +is_a: GO:0005244 ! voltage-gated ion channel activity +is_a: GO:0005253 ! anion channel activity + +[Term] +id: GO:0008309 +name: double-stranded DNA exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] +synonym: "double-stranded DNA specific exodeoxyribonuclease activity" RELATED [] +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008310 +name: single-stranded DNA 3'-5' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] +synonym: "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] +synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" RELATED [GOC:mah] +is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity +is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity + +[Term] +id: GO:0008311 +name: double-stranded DNA 3'-5' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] +synonym: "double-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] +is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity +is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity + +[Term] +id: GO:0008312 +name: 7S RNA binding +namespace: molecular_function +def: "Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0008313 +name: gurken-activated receptor activity +namespace: molecular_function +def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] +synonym: "gurken receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0005006 ! epidermal growth factor-activated receptor activity + +[Term] +id: GO:0008314 +name: gurken signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken." [GOC:bf, PMID:23972992] +synonym: "gurken receptor signaling pathway" EXACT [] +synonym: "gurken receptor signalling pathway" EXACT [] +synonym: "gurken-activated signaling pathway" RELATED [GOC:signaling] +synonym: "signaling by Gurken" EXACT [GOC:bf] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0008315 +name: G2/MI transition of meiotic cell cycle +namespace: biological_process +def: "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480] +synonym: "meiotic cell cycle G2/MI phase transition" EXACT [] +synonym: "meiotic G2/MI phase transition" EXACT [] +synonym: "meiotic G2/MI transition" EXACT [] +is_a: GO:0044771 ! meiotic cell cycle phase transition +is_a: GO:0044839 ! cell cycle G2/M phase transition +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:0008316 +name: structural constituent of vitelline membrane +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0008317 +name: gurken receptor binding +namespace: molecular_function +def: "Binding to a gurken growth factor receptor." [GOC:ai] +synonym: "gurken receptor ligand" NARROW [] +is_a: GO:0005154 ! epidermal growth factor receptor binding + +[Term] +id: GO:0008318 +name: protein prenyltransferase activity +namespace: molecular_function +alt_id: GO:0008244 +def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] +is_a: GO:0004659 ! prenyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008319 +name: obsolete prenyl protein specific endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "prenyl protein specific endopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008320 +name: protein transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015266 +alt_id: GO:0015463 +def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] +synonym: "protein channel activity" RELATED [] +xref: Reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" +xref: Reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix" +xref: Reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" +xref: Reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" +xref: Reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" +xref: Reactome:R-HSA-5210943 "pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)" +xref: Reactome:R-HSA-5210947 "pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)" +xref: Reactome:R-HSA-5228406 "tetX HC transports tetX LC from target cell endosome membrane into cytosol" +xref: Reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" +xref: Reactome:R-HSA-5244404 "botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5244428 "botA HC transports botA LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5244506 "botE HC transports botE LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5246514 "botC HC transports botC LC from target cell synaptic vesicle membrane to cytosol" +xref: Reactome:R-HSA-5250616 "botD HC transports botD LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5250884 "botF HC transports botF LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5250972 "botG HC transports botG LC from target cell synaptic vesicle membrane into cytosol" +xref: Reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" +xref: Reactome:R-HSA-9636375 "SecA2 transports SapM from cytoplasm to cytosol" +xref: Reactome:R-HSA-9698930 "HCMV C Nucleocapsid Translocation" +xref: Reactome:R-HSA-9698933 "HCMV B Nucleocapsid Translocation" +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +is_a: GO:0140318 ! protein transporter activity + +[Term] +id: GO:0008322 +name: obsolete Pro-X carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "Pro-X carboxypeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030536 + +[Term] +id: GO:0008324 +name: cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "transmembrane cation transporter activity" EXACT [] +is_a: GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0008327 +name: methyl-CpG binding +namespace: molecular_function +def: "Binding to a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0008328 +name: ionotropic glutamate receptor complex +namespace: cellular_component +def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] +is_a: GO:0034702 ! ion channel complex +is_a: GO:0098878 ! neurotransmitter receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0008330 +name: protein tyrosine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0008331 +name: high voltage-gated calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] +synonym: "high voltage gated calcium channel activity" EXACT [] +synonym: "high voltage-dependent calcium channel activity" EXACT [] +synonym: "L-type calcium channel" RELATED [] +synonym: "N-type calcium channel" RELATED [] +synonym: "P-type calcium channel" RELATED [] +synonym: "Q-type calcium channel" RELATED [] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0008332 +name: low voltage-gated calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] +synonym: "low voltage gated calcium channel activity" EXACT [] +synonym: "low voltage-dependent calcium channel activity" EXACT [] +synonym: "T-type calcium channel" RELATED [] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0008333 +name: endosome to lysosome transport +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0008334 +name: histone mRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393] +comment: In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated. +synonym: "histone mRNA metabolism" EXACT [] +synonym: "stem-loop-containing histone mRNA 3'-end processing" NARROW [GOC:krc, GOC:mah, PMID:17855393] +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0008335 +name: female germline ring canal stabilization +namespace: biological_process +def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] +synonym: "nurse cell ring canal stabilization" NARROW [] +synonym: "ovarian ring canal stabilization" NARROW [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + +[Term] +id: GO:0008336 +name: gamma-butyrobetaine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24028] +synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.1] +synonym: "alpha-butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1] +synonym: "butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1] +synonym: "g-butyrobetaine dioxygenase activity" EXACT [] +synonym: "gamma-BBH activity" RELATED [EC:1.14.11.1] +synonym: "gamma-butyrobetaine hydroxylase activity" RELATED [EC:1.14.11.1] +synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] +xref: EC:1.14.11.1 +xref: KEGG_REACTION:R02397 +xref: MetaCyc:1.14.11.1-RXN +xref: Reactome:R-HSA-71261 "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA" +xref: RHEA:24028 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0008337 +name: obsolete selectin +namespace: molecular_function +def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] +comment: This term was made obsolete because it describes a class of gene products. +synonym: "selectin" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0007155 +consider: GO:0016021 +consider: GO:0030246 +consider: GO:0050839 + +[Term] +id: GO:0008340 +name: determination of adult lifespan +namespace: biological_process +def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0010259 ! multicellular organism aging + +[Term] +id: GO:0008341 +name: obsolete response to cocaine (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "response to cocaine (sensu Insecta)" EXACT [] +is_obsolete: true +consider: GO:0048148 + +[Term] +id: GO:0008342 +name: obsolete larval feeding behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah] +comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. +synonym: "larval feeding behavior (sensu Insecta)" EXACT [] +is_obsolete: true +replaced_by: GO:0030536 + +[Term] +id: GO:0008343 +name: adult feeding behavior +namespace: biological_process +def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] +comment: See also the biological process term 'feeding behavior ; GO:0007631'. +synonym: "adult feeding behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0030534 ! adult behavior + +[Term] +id: GO:0008344 +name: adult locomotory behavior +namespace: biological_process +def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] +comment: See also the biological process term 'locomotory behavior ; GO:0007626'. +synonym: "adult locomotory behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0030534 ! adult behavior + +[Term] +id: GO:0008345 +name: larval locomotory behavior +namespace: biological_process +def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] +comment: See also the biological process term 'locomotory behavior ; GO:0007626'. +synonym: "larval locomotory behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0030537 ! larval behavior + +[Term] +id: GO:0008346 +name: larval walking behavior +namespace: biological_process +def: "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators, GOC:pr] +synonym: "larval walking behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior +is_a: GO:0090659 ! walking behavior + +[Term] +id: GO:0008347 +name: glial cell migration +namespace: biological_process +alt_id: GO:0043359 +def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] +synonym: "glia cell migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0008348 +name: negative regulation of antimicrobial humoral response +namespace: biological_process +alt_id: GO:0042154 +alt_id: GO:0042155 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] +synonym: "attenuation of antimicrobial humoral response" EXACT [] +synonym: "down regulation of antimicrobial humoral response" EXACT [] +synonym: "down-regulation of antimicrobial humoral response" EXACT [] +synonym: "downregulation of antimicrobial humoral response" EXACT [] +synonym: "inhibition of antimicrobial humoral response" NARROW [] +is_a: GO:0002759 ! regulation of antimicrobial humoral response +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0032102 ! negative regulation of response to external stimulus +relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0008349 +name: MAP kinase kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] +synonym: "MAP4K activity" EXACT [PMID:20811974] +synonym: "MAPKKKK" EXACT [] +xref: Reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex" +xref: Reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3" +xref: Reactome:R-HSA-9645442 "Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex" +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0008350 +name: obsolete kinetochore motor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it includes cellular component information. +synonym: "kinetochore motor activity" EXACT [] +is_obsolete: true +consider: GO:0000776 +consider: GO:0003777 + +[Term] +id: GO:0008351 +name: obsolete microtubule severing activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a biological process. +synonym: "microtubule severing activity" EXACT [] +is_obsolete: true +consider: GO:0008017 +consider: GO:0051013 + +[Term] +id: GO:0008352 +name: katanin complex +namespace: cellular_component +def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] +comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. +is_a: GO:0005875 ! microtubule associated complex +relationship: part_of GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0008353 +name: RNA polymerase II CTD heptapeptide repeat kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] +synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] +synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] +synonym: "CTD kinase activity" RELATED [EC:2.7.11.23] +synonym: "RNA polymerase II carboxy-terminal domain kinase activity" EXACT [] +synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] +synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] +synonym: "STK9" RELATED [EC:2.7.11.23] +xref: EC:2.7.11.23 +xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN +xref: Reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex" +xref: Reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex" +xref: Reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex" +xref: RHEA:10216 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0008354 +name: germ cell migration +namespace: biological_process +def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] +synonym: "germ-cell migration" EXACT [] +synonym: "primordial germ cell migration" RELATED [] +is_a: GO:0016477 ! cell migration +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0008355 +name: olfactory learning +namespace: biological_process +def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] +is_a: GO:0008306 ! associative learning +is_a: GO:0042048 ! olfactory behavior + +[Term] +id: GO:0008356 +name: asymmetric cell division +namespace: biological_process +def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] +synonym: "asymmetric cytokinesis" RELATED [] +synonym: "asymmetrical cell division" EXACT [] +synonym: "asymmetrical cytokinesis" RELATED [] +xref: Wikipedia:Asymmetric_cell_division +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0008358 +name: maternal determination of anterior/posterior axis, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +is_a: GO:0008595 ! anterior/posterior axis specification, embryo + +[Term] +id: GO:0008359 +name: regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] +synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah] +is_a: GO:1904580 ! regulation of intracellular mRNA localization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0008360 +name: regulation of cell shape +namespace: biological_process +alt_id: GO:0045788 +alt_id: GO:0045789 +def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0008361 +name: regulation of cell size +namespace: biological_process +def: "Any process that modulates the size of a cell." [GOC:go_curators] +synonym: "cell size control" EXACT [] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0008362 +name: chitin-based embryonic cuticle biosynthetic process +namespace: biological_process +def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] +synonym: "embryonic cuticle anabolism" BROAD [] +synonym: "embryonic cuticle biosynthetic process" BROAD [] +synonym: "embryonic cuticle formation" BROAD [] +synonym: "embryonic cuticle synthesis" BROAD [] +is_a: GO:0040003 ! chitin-based cuticle development + +[Term] +id: GO:0008363 +name: larval chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "larval cuticle anabolism" BROAD [] +synonym: "larval cuticle biosynthetic process" BROAD [] +synonym: "larval cuticle formation" BROAD [] +synonym: "larval cuticle synthesis" BROAD [] +is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle +relationship: part_of GO:0002168 ! instar larval development + +[Term] +id: GO:0008364 +name: pupal chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "pupal cuticle anabolism" BROAD [] +synonym: "pupal cuticle formation" BROAD [] +synonym: "pupal cuticle synthesis" BROAD [] +is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle +relationship: part_of GO:0035209 ! pupal development + +[Term] +id: GO:0008365 +name: adult chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +synonym: "adult chitin-based cuticle anabolism" EXACT [] +synonym: "adult chitin-based cuticle biosynthetic process" EXACT [] +synonym: "adult chitin-based cuticle formation" EXACT [] +synonym: "adult chitin-based cuticle synthesis" EXACT [] +synonym: "adult cuticle anabolism" BROAD [] +synonym: "adult cuticle biosynthetic process" BROAD [] +synonym: "adult cuticle formation" BROAD [] +synonym: "adult cuticle synthesis" BROAD [] +is_a: GO:0040003 ! chitin-based cuticle development + +[Term] +id: GO:0008366 +name: axon ensheathment +namespace: biological_process +alt_id: GO:0042553 +def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] +synonym: "cellular axon ensheathment" EXACT [] +synonym: "cellular nerve ensheathment" RELATED [] +synonym: "nerve ensheathment" RELATED [] +is_a: GO:0007272 ! ensheathment of neurons + +[Term] +id: GO:0008369 +name: obsolete molecular function +namespace: molecular_function +def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008370 +name: obsolete cellular component +namespace: cellular_component +def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008371 +name: obsolete biological process +namespace: biological_process +def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] +comment: This term was made obsolete because it is unnecessary in the OBO flat file format. +is_obsolete: true + +[Term] +id: GO:0008373 +name: sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [GOC:cjm, PMID:26192491, Wikipedia:Sialyltransferase] +xref: Reactome:R-HSA-9683769 "O-glycosylation of 3a is terminated" +xref: Reactome:R-HSA-9694718 "O-glycosylation of 3a is terminated" +xref: Reactome:R-HSA-9697018 "Addition of sialic acids on some Spike glycosyl sidechains" +xref: Reactome:R-HSA-981814 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position" +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0008374 +name: O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-1482775 "MLCL is acylated to CL by HADH (IM)" +xref: Reactome:R-HSA-1482781 "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)" +xref: Reactome:R-HSA-1482850 "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)" +xref: Reactome:R-HSA-1482861 "MLCL is acylated to CL by LCLAT1 (ER)" +xref: Reactome:R-HSA-1482867 "DLCL is acylated to MLCL by LCLAT1 (ER)" +xref: Reactome:R-HSA-162683 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH" +xref: Reactome:R-HSA-3238694 "PORCN palmitoleoylates N-glycosyl WNTs" +xref: Reactome:R-HSA-422017 "Ghrelin O-acyltransferase decanoylates Proghrelin" +xref: Reactome:R-HSA-422104 "Ghrelin O-acyltransferase octanoylates Proghrelin" +xref: Reactome:R-HSA-5358343 "HHAT palmitoylates Hh N-terminal fragment" +xref: Reactome:R-HSA-5483229 "HHAT G287V doesn't palmitoylate Hh-Np" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0008375 +name: acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] +synonym: "GlcNAc transferase activity" EXACT [] +xref: Reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins" +xref: Reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1" +xref: Reactome:R-HSA-9683648 "Spike trimer glycoside chains are extended" +xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended" +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008376 +name: acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] +synonym: "GalNAc transferase activity" EXACT [] +xref: Reactome:R-HSA-8855954 "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD" +xref: Reactome:R-HSA-8931648 "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1" +xref: Reactome:R-HSA-9605700 "B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda" +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008377 +name: light-induced release of internally sequestered calcium ion +namespace: biological_process +def: "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] +synonym: "light-induced release of calcium from internal store" EXACT [] +synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] +synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] +is_a: GO:0051283 ! negative regulation of sequestering of calcium ion +relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0008378 +name: galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] +xref: Reactome:R-HSA-1964501 "Addition of galactose to Core 6 glycoprotein" +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008379 +name: thioredoxin peroxidase activity +namespace: molecular_function +alt_id: GO:0009031 +def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [RHEA:63528] +synonym: "thiol peroxidase activity" EXACT [] +synonym: "TPx activity" EXACT [] +synonym: "TrxPx activity" EXACT [] +xref: MetaCyc:RXN0-267 +xref: Reactome:R-HSA-2161612 "PGH2 is reduced to PGF2a by FAM213B" +xref: Reactome:R-HSA-3322995 "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O" +xref: Reactome:R-HSA-3341343 "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O" +xref: Reactome:R-HSA-3697882 "PRDX5 reduces peroxynitrite to nitrite using TXN" +xref: Reactome:R-HSA-3697894 "PRDX5 reduces peroxynitrite to nitrite using TXN2" +xref: RHEA:63528 +is_a: GO:0004601 ! peroxidase activity +is_a: GO:0051920 ! peroxiredoxin activity + +[Term] +id: GO:0008380 +name: RNA splicing +namespace: biological_process +alt_id: GO:0006395 +def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] +subset: goslim_yeast +synonym: "pre-mRNA splicing factor activity" RELATED [] +xref: Wikipedia:RNA_splicing +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0008381 +name: mechanosensitive ion channel activity +namespace: molecular_function +alt_id: GO:0022833 +def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] +synonym: "mechanically gated channel activity" EXACT [] +synonym: "mechanically-gated channel activity" EXACT [] +synonym: "mechanically-gated ion channel activity" EXACT [] +xref: TC:1.A.23.2.1 +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0008384 +name: IkappaB kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] +comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. +synonym: "ATP:IkappaB protein phosphotransferase activity" RELATED [EC:2.7.11.10] +synonym: "CHUK" RELATED [EC:2.7.11.10] +synonym: "IKBKA" RELATED [EC:2.7.11.10] +synonym: "IKBKB" RELATED [EC:2.7.11.10] +synonym: "IKK" RELATED [EC:2.7.11.10] +synonym: "IKK-1" RELATED [EC:2.7.11.10] +synonym: "IKK-2" RELATED [EC:2.7.11.10] +synonym: "inhibitor of NF-kappaB kinase activity" RELATED [EC:2.7.11.10] +synonym: "inhibitor of NFkappaB kinase activity" RELATED [EC:2.7.11.10] +synonym: "STK12" RELATED [EC:2.7.11.10] +synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] +synonym: "TBK1" RELATED [EC:2.7.11.10] +xref: EC:2.7.11.10 +xref: MetaCyc:2.7.11.10-RXN +xref: Reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex" +xref: Reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400" +xref: RHEA:19073 +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0008385 +name: IkappaB kinase complex +namespace: cellular_component +def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203] +synonym: "heterotrimeric IKK complex" EXACT [GOC:bf] +synonym: "IKK complex" EXACT [] +synonym: "trimeric IKK complex" EXACT [PMID:21173796] +is_a: GO:1902554 ! serine/threonine protein kinase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0008386 +name: cholesterol monooxygenase (side-chain-cleaving) activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] +synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] +synonym: "cholesterol 20-22-desmolase activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol C(20-22) desmolase activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol C20-22 desmolase activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol desmolase activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] +synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" RELATED [EC:1.14.15.6] +synonym: "Cyp11a1" NARROW [] +synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] +synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] +synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] +synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] +synonym: "desmolase, steroid 20-22" RELATED [EC:1.14.15.6] +synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] +synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] +synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] +xref: EC:1.14.15.6 +xref: MetaCyc:1.14.15.6-RXN +xref: Reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol" +xref: Reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol" +xref: Reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL" +xref: RHEA:35739 +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008387 +name: steroid 7-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] +synonym: "cytochrome P450 CYP2A12" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008388 +name: testosterone 15-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] +synonym: "cytochrome P450 CYP2A4" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008389 +name: coumarin 7-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] +synonym: "cytochrome P450 CYP2A5" NARROW [] +xref: Reactome:R-HSA-211881 "Coumarin is 7-hydroxylated by CYP2A13" +xref: Reactome:R-HSA-76453 "Coumarin is 7-hydroxylated by CYP2A6" +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008390 +name: testosterone 16-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O." [GOC:ai] +synonym: "cytochrome P450 CYP2B10" NARROW [] +synonym: "cytochrome P450 CYP2B9" NARROW [] +synonym: "cytochrome P450 CYP2D10" NARROW [] +synonym: "cytochrome P450 CYP2D11" NARROW [] +synonym: "cytochrome P450 CYP2D9" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008391 +name: arachidonic acid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah] +synonym: "cytochrome P450 CYP2B19" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008392 +name: arachidonic acid epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, PMID:18952572] +synonym: "cytochrome P450 CYP2J5" NARROW [] +synonym: "cytochrome P450 CYP2J6" NARROW [] +xref: Reactome:R-HSA-211983 "CYP2J2 oxidises ARA" +is_a: GO:0008391 ! arachidonic acid monooxygenase activity + +[Term] +id: GO:0008395 +name: steroid hydroxylase activity +namespace: molecular_function +alt_id: GO:0008394 +def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544] +synonym: "cytochrome P450 CYP2G1" NARROW [] +synonym: "olfactory-specific steroid hydroxylase activity" NARROW [] +xref: Reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol" +xref: Reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol" +xref: Reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al" +xref: Reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)" +xref: Reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL" +xref: Reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1" +xref: Reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b" +xref: Reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol" +xref: Reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)" +xref: Reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al" +xref: Reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)" +xref: Reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al" +xref: Reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)" +xref: Reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al" +xref: Reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol" +xref: Reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol" +xref: Reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO" +xref: Reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST" +xref: Reactome:R-HSA-5601849 "Defective CYP19A1 does not convert ANDST to E1" +xref: Reactome:R-HSA-5602170 "CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol" +xref: Reactome:R-HSA-6785244 "Defective CYP11B2 does not oxidise 18HCORST" +xref: Reactome:R-HSA-6785245 "Defective CYP11B2 does not oxidise CORST" +xref: Reactome:R-HSA-9035960 "Defective CYP27A1 does not 27-hydroxylate 5-CHOL3,7,24(s)-triol" +xref: RHEA:43836 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0008396 +name: oxysterol 7-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] +synonym: "cytochrome P450 CYP7B1" NARROW [] +xref: Reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated" +xref: Reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL" +xref: Reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL" +xref: Reactome:R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL" +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008397 +name: sterol 12-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] +synonym: "cytochrome P450 CYP8B1" NARROW [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008398 +name: sterol 14-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:54028] +synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.14.154] +synonym: "cytochrome P450 CYP51" NARROW [] +synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.14.154] +synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.14.154] +synonym: "lanosterol 14alpha-demethylase activity" RELATED [EC:1.14.14.154] +synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.14.154] +synonym: "sterol 14-alpha-demethylase activity" RELATED [] +synonym: "sterol 14alpha-demethylase activity" RELATED [] +xref: EC:1.14.14.154 +xref: MetaCyc:1.14.13.70-RXN +xref: Reactome:R-HSA-194678 "CYP51A1 demethylates LNSOL" +xref: RHEA:54028 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0008399 +name: naphthalene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702] +synonym: "cytochrome P450 CYP2F2" NARROW [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008401 +name: retinoic acid 4-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282, PMID:9250660] +synonym: "cytochrome P450 CYP261" NARROW [] +xref: Reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA" +xref: Reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA" +xref: Reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA" +xref: Reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA" +xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA" +xref: Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA" +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008403 +name: 25-hydroxycholecalciferol-24-hydroxylase activity +namespace: molecular_function +alt_id: GO:0030344 +def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309] +synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] +synonym: "cytochrome P450 CYP24" NARROW [] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0070576 ! vitamin D 24-hydroxylase activity + +[Term] +id: GO:0008404 +name: arachidonic acid 14,15-epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51472] +synonym: "cytochrome P450 CYP2C29" NARROW [] +synonym: "cytochrome P450 CYP2C39" NARROW [] +xref: RHEA:51472 +is_a: GO:0008392 ! arachidonic acid epoxygenase activity + +[Term] +id: GO:0008405 +name: arachidonic acid 11,12-epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399, RHEA:51480] +synonym: "cytochrome P450 CYP2C38" NARROW [] +xref: RHEA:51480 +is_a: GO:0008392 ! arachidonic acid epoxygenase activity + +[Term] +id: GO:0008406 +name: gonad development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] +synonym: "gonadogenesis" EXACT [GOC:cjm] +is_a: GO:0048513 ! animal organ development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0045137 ! development of primary sexual characteristics + +[Term] +id: GO:0008407 +name: chaeta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] +synonym: "bristle morphogenesis" NARROW [GOC:bf, GOC:dos] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0022416 ! chaeta development + +[Term] +id: GO:0008408 +name: 3'-5' exonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] +synonym: "3'-5'-exonuclease activity" EXACT [] +xref: Reactome:R-HSA-3245943 "Viral DNA cleavage by TREX1" +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0008409 +name: 5'-3' exonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] +xref: Reactome:R-HSA-5358599 "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch" +xref: Reactome:R-HSA-5358619 "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)" +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0008410 +name: CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] +xref: EC:2.8.3.- +xref: Reactome:R-HSA-70713 "BCKDH transfers CoA group from CoA-SH to BCAAs" +is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups + +[Term] +id: GO:0008411 +name: 4-hydroxybutyrate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008412 +name: 4-hydroxybenzoate octaprenyltransferase activity +namespace: molecular_function +alt_id: GO:0000043 +alt_id: GO:0048043 +alt_id: GO:0048044 +def: "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [RHEA:27782] +synonym: "4-HB polyprenyltransferase activity" EXACT [] +synonym: "para-hydroxybenzoate transferase activity" EXACT [] +synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] +synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] +synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] +xref: EC:2.5.1.39 +xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN +xref: RHEA:27782 +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0008413 +name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881, RHEA:60032] +synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] +synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT [] +synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT [] +synonym: "8-oxo-GTPase activity" EXACT [] +xref: EC:3.6.1.69 +xref: RHEA:60032 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0008414 +name: CDP-alcohol phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0008417 +name: fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +xref: Reactome:R-HSA-9033949 "FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC" +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008418 +name: protein-N-terminal asparagine amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008419 +name: RNA lariat debranching enzyme activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008420 +name: RNA polymerase II CTD heptapeptide repeat phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate." [PMID:22622228] +synonym: "CTD phosphatase activity" EXACT [] +synonym: "RNA polymerase II carboxy-terminal domain phosphatase activity" EXACT [] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0008421 +name: long-chain fatty-acyl-glutamate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] +synonym: "long-chain acylglutamate amidase activity" RELATED [EC:3.5.1.55] +synonym: "long-chain aminoacylase activity" RELATED [EC:3.5.1.55] +synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah] +synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] +synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.55] +xref: EC:3.5.1.55 +xref: MetaCyc:3.5.1.55-RXN +xref: RHEA:17517 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008422 +name: beta-glucosidase activity +namespace: molecular_function +alt_id: GO:0016983 +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] +synonym: "amygdalase activity" NARROW [EC:3.2.1.21] +synonym: "amygdalinase" BROAD [EC:3.2.1.21] +synonym: "arbutinase activity" RELATED [EC:3.2.1.21] +synonym: "aryl-beta-glucosidase activity" RELATED [EC:3.2.1.21] +synonym: "beta-1,6-glucosidase activity" RELATED [EC:3.2.1.21] +synonym: "beta-D-glucosidase activity" RELATED [EC:3.2.1.21] +synonym: "beta-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.21] +synonym: "beta-glucoside glucohydrolase activity" RELATED [EC:3.2.1.21] +synonym: "cellobiase activity" NARROW [EC:3.2.1.21] +synonym: "cytokine beta-glucosidase activity" NARROW [] +synonym: "elaterase activity" NARROW [EC:3.2.1.21] +synonym: "emulsin" RELATED [EC:3.2.1.21] +synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] +synonym: "gentobiase activity" NARROW [EC:3.2.1.21] +synonym: "limarase activity" NARROW [EC:3.2.1.21] +synonym: "p-nitrophenyl beta-glucosidase activity" RELATED [EC:3.2.1.21] +synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] +synonym: "salicilinase activity" NARROW [EC:3.2.1.21] +xref: EC:3.2.1.21 +xref: MetaCyc:3.2.1.21-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0008423 +name: obsolete bleomycin hydrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] +synonym: "bleomycin hydrolase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0008424 +name: glycoprotein 6-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+)." [EC:2.4.1.68, RHEA:12985] +synonym: "FucT" RELATED [EC:2.4.1.68] +synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "GDPfucose-glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68] +synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] +synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" RELATED [EC:2.4.1.68] +xref: EC:2.4.1.68 +xref: KEGG_REACTION:R05988 +xref: MetaCyc:2.4.1.68-RXN +xref: Reactome:R-HSA-1028788 "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP" +xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches" +xref: RHEA:12985 +is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0008425 +name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] +synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] +synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] +synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] +synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] +xref: EC:2.1.1.- +is_a: GO:0030580 ! quinone cofactor methyltransferase activity + +[Term] +id: GO:0008426 +name: protein kinase C inhibitor activity +namespace: molecular_function +alt_id: GO:0004863 +def: "Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] +synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] +synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT [] +synonym: "PKC inhibitor activity" EXACT [] +is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity + +[Term] +id: GO:0008427 +name: calcium-dependent protein kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity +is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity + +[Term] +id: GO:0008428 +name: ribonuclease inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of ribonuclease." [GOC:ai] +is_a: GO:0140721 ! nuclease inhibitor activity + +[Term] +id: GO:0008429 +name: phosphatidylethanolamine binding +namespace: molecular_function +def: "Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0008430 +name: selenium binding +namespace: molecular_function +def: "Binding to a selenium (Se) ion." [GOC:ai] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0008431 +name: vitamin E binding +namespace: molecular_function +def: "Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [ISBN:0721662544] +synonym: "alpha-tocopherol binding" NARROW [] +synonym: "tocopherol binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0008432 +name: JUN kinase binding +namespace: molecular_function +def: "Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] +synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0008435 +name: obsolete anticoagulant activity +namespace: molecular_function +def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732] +comment: This term was made obsolete because it represents a biological process. +synonym: "anticoagulant activity" EXACT [] +is_obsolete: true +replaced_by: GO:0050819 + +[Term] +id: GO:0008436 +name: obsolete heterogeneous nuclear ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] +synonym: "hnRNP" EXACT [] +is_obsolete: true +replaced_by: GO:1990904 + +[Term] +id: GO:0008437 +name: thyrotropin-releasing hormone activity +namespace: molecular_function +def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732] +synonym: "thyrotropin releasing hormone activity" EXACT [] +synonym: "TRH activity" EXACT [ISBN:0198506732] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0008438 +name: obsolete 1-phosphatidylinositol-5-phosphate kinase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [GOC:curators] +comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. +synonym: "1-phosphatidylinositol-5-phosphate kinase" EXACT [] +is_obsolete: true +consider: GO:0016309 + +[Term] +id: GO:0008439 +name: obsolete monophenol monooxygenase activator activity +namespace: molecular_function +def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "monophenol monooxygenase activator activity" EXACT [] +synonym: "prophenol oxidase activator" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008440 +name: inositol-1,4,5-trisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11020] +synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" RELATED [EC:2.7.1.127] +synonym: "inositol trisphosphate 3-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] +synonym: "ins(1,4,5)P(3) 3-kinase activity" RELATED [EC:2.7.1.127] +synonym: "Ins(1,4,5)P3 3-kinase activity" RELATED [EC:2.7.1.127] +synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] +synonym: "IP3K activity" NARROW [EC:2.7.1.127] +xref: EC:2.7.1.127 +xref: KEGG_REACTION:R03433 +xref: MetaCyc:2.7.1.127-RXN +xref: Reactome:R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol" +xref: Reactome:R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus" +xref: RHEA:11020 +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0008441 +name: 3'(2'),5'-bisphosphate nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] +synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] +synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" RELATED [EC:3.1.3.7] +synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" RELATED [EC:3.1.3.7] +synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" RELATED [EC:3.1.3.7] +synonym: "DPNPase activity" RELATED [EC:3.1.3.7] +synonym: "phosphoadenylate 3'-nucleotidase activity" RELATED [EC:3.1.3.7] +xref: EC:3.1.3.7 +xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN +xref: Reactome:R-HSA-176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" +xref: Reactome:R-HSA-8953499 "IMPAD1 hydrolyses PAP to AMP" +xref: RHEA:10040 +is_a: GO:0008252 ! nucleotidase activity + +[Term] +id: GO:0008442 +name: 3-hydroxyisobutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] +xref: EC:1.1.1.31 +xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-508473 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+" +xref: Reactome:R-HSA-70885 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+" +xref: RHEA:17681 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008443 +name: phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008444 +name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12593] +synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" RELATED [EC:2.7.8.5] +synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "glycerol 3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "glycerol phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "glycerophosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +synonym: "PGP synthase activity" RELATED [EC:2.7.8.5] +synonym: "phosphatidylglycerol phosphate synthase activity" RELATED [EC:2.7.8.5] +synonym: "phosphatidylglycerol phosphate synthetase activity" RELATED [EC:2.7.8.5] +synonym: "phosphatidylglycerolphosphate synthase activity" RELATED [EC:2.7.8.5] +synonym: "phosphatidylglycerophosphate synthase activity" RELATED [EC:2.7.8.5] +synonym: "phosphatidylglycerophosphate synthetase activity" RELATED [EC:2.7.8.5] +synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" RELATED [EC:2.7.8.5] +xref: EC:2.7.8.5 +xref: KEGG_REACTION:R01801 +xref: MetaCyc:PHOSPHAGLYPSYN-RXN +xref: Reactome:R-HSA-1482939 "CDP-DAG is converted to PGP by PGS1" +xref: RHEA:12593 +is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity + +[Term] +id: GO:0008445 +name: D-aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1] +synonym: "aspartic oxidase activity" RELATED [EC:1.4.3.1] +synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.1] +synonym: "D-aspartic oxidase activity" RELATED [EC:1.4.3.1] +xref: EC:1.4.3.1 +xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN +xref: Reactome:R-HSA-6810076 "DDO oxidizes D-Asp to OA" +xref: RHEA:12512 +is_a: GO:0003884 ! D-amino-acid oxidase activity +is_a: GO:0015922 ! aspartate oxidase activity + +[Term] +id: GO:0008446 +name: GDP-mannose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23820] +synonym: "GDP-D-mannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47] +synonym: "GDP-D-mannose dehydratase activity" RELATED [EC:4.2.1.47] +synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" RELATED [EC:4.2.1.47] +synonym: "GDP-mannose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.47] +synonym: "GDPmannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47] +synonym: "Gmd" RELATED [EC:4.2.1.47] +synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" RELATED [EC:4.2.1.47] +synonym: "guanosine diphosphomannose 4,6-dehydratase activity" RELATED [EC:4.2.1.47] +synonym: "guanosine diphosphomannose oxidoreductase activity" RELATED [EC:4.2.1.47] +xref: EC:4.2.1.47 +xref: KEGG_REACTION:R00888 +xref: MetaCyc:GDPMANDEHYDRA-RXN +xref: Reactome:R-HSA-6787632 "GMDS dehydrates GDP-Man to GDP-DHDMan" +xref: RHEA:23820 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008447 +name: L-ascorbate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 L-ascorbate + O(2) <=> 4 monodehydroascorbate + 2 H(2)O." [RHEA:30243] +synonym: "AA oxidase activity" RELATED [EC:1.10.3.3] +synonym: "AAO" RELATED [EC:1.10.3.3] +synonym: "ascorbase activity" RELATED [EC:1.10.3.3] +synonym: "ascorbate dehydrogenase activity" RELATED [EC:1.10.3.3] +synonym: "ascorbate oxidase activity" RELATED [EC:1.10.3.3] +synonym: "ascorbic acid oxidase activity" RELATED [EC:1.10.3.3] +synonym: "ascorbic oxidase activity" RELATED [EC:1.10.3.3] +synonym: "L-ascorbate:O2 oxidoreductase activity" RELATED [EC:1.10.3.3] +synonym: "L-ascorbate:oxygen oxidoreductase activity" RELATED [EC:1.10.3.3] +synonym: "L-ascorbic acid oxidase activity" RELATED [EC:1.10.3.3] +xref: EC:1.10.3.3 +xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN +xref: RHEA:30243 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0008448 +name: N-acetylglucosamine-6-phosphate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] +synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" RELATED [EC:3.5.1.25] +synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" RELATED [EC:3.5.1.25] +synonym: "acetylglucosamine phosphate deacetylase activity" RELATED [EC:3.5.1.25] +synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" RELATED [EC:3.5.1.25] +xref: EC:3.5.1.25 +xref: MetaCyc:NAG6PDEACET-RXN +xref: Reactome:R-HSA-6803789 "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA" +xref: RHEA:22936 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008449 +name: N-acetylglucosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] +synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" RELATED [EC:3.1.6.14] +synonym: "acetylglucosamine 6-sulfatase activity" RELATED [EC:3.1.6.14] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] +synonym: "glucosamine-6-sulfatase activity" RELATED [EC:3.1.6.14] +synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" RELATED [EC:3.1.6.14] +synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" RELATED [EC:3.1.6.14] +synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] +synonym: "O,N-disulfate O-sulfohydrolase activity" RELATED [EC:3.1.6.14] +xref: EC:3.1.6.14 +xref: MetaCyc:3.1.6.14-RXN +xref: Reactome:R-HSA-1638032 "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate" +xref: Reactome:R-HSA-2263495 "Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S" +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0008450 +name: obsolete O-sialoglycoprotein endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "glycophorin A proteinase activity" RELATED [] +synonym: "glycoprotease activity" RELATED [] +synonym: "glycoproteinase activity" RELATED [] +synonym: "O-sialoglycoprotein endopeptidase activity" EXACT [] +synonym: "sialoglycoprotease activity" RELATED [] +synonym: "sialoglycoproteinase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008451 +name: obsolete X-Pro aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoacylproline aminopeptidase activity" RELATED [EC:3.4.11.9] +synonym: "aminopeptidase P" EXACT [] +synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] +synonym: "X-Pro aminopeptidase activity" EXACT [] +synonym: "Xaa-Pro aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0008452 +name: RNA ligase activity +namespace: molecular_function +def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah] +is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0008453 +name: alanine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] +synonym: "AGT activity" RELATED [EC:2.6.1.44] +synonym: "alanine--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.44] +synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] +synonym: "alanine-glyoxylic aminotransferase activity" RELATED [EC:2.6.1.44] +synonym: "L-alanine-glycine transaminase activity" RELATED [EC:2.6.1.44] +synonym: "L-alanine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.44] +xref: EC:2.6.1.44 +xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-389684 "glyoxylate + alanine => glycine + pyruvate [peroxisome]" +xref: Reactome:R-HSA-904864 "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate" +xref: RHEA:24248 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008454 +name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] +synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.145] +synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "beta-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145] +synonym: "GnTIV activity" RELATED [EC:2.4.1.145] +synonym: "N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145] +synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.145] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.145] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] +xref: EC:2.4.1.145 +xref: MetaCyc:2.4.1.145-RXN +xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches" +xref: Reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV" +xref: RHEA:16057 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0008455 +name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] +synonym: "acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143] +synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "GnTII activity" RELATED [EC:2.4.1.143] +synonym: "N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.143] +synonym: "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.143] +xref: EC:2.4.1.143 +xref: MetaCyc:2.4.1.143-RXN +xref: Reactome:R-HSA-4793955 "Defective MGAT2 does not transfer GlcNAc to N-glycans" +xref: Reactome:R-HSA-9694656 "Spike trimer glycoside chains are extended" +xref: Reactome:R-HSA-975829 "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2" +xref: RHEA:12941 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0008456 +name: alpha-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] +synonym: "alpha-acetylgalactosaminidase activity" RELATED [EC:3.2.1.49] +synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] +synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" RELATED [EC:3.2.1.49] +synonym: "alpha-NAGA activity" RELATED [EC:3.2.1.49] +synonym: "N-acetyl-alpha-D-galactosaminidase activity" RELATED [EC:3.2.1.49] +synonym: "N-acetyl-alpha-galactosaminidase activity" RELATED [EC:3.2.1.49] +xref: EC:3.2.1.49 +xref: MetaCyc:3.2.1.49-RXN +xref: RHEA:15085 +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0008457 +name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.149] +synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] +xref: EC:2.4.1.149 +xref: MetaCyc:2.4.1.163-RXN +xref: RHEA:23004 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008458 +name: carnitine O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17177] +synonym: "carnitine medium-chain acyltransferase activity" RELATED [EC:2.3.1.137] +synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] +synonym: "medium-chain/long-chain carnitine acyltransferase activity" RELATED [EC:2.3.1.137] +synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" RELATED [EC:2.3.1.137] +synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] +xref: EC:2.3.1.137 +xref: KEGG_REACTION:R03779 +xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN +xref: Reactome:R-HSA-390281 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH" +xref: RHEA:17177 +is_a: GO:0016406 ! carnitine O-acyltransferase activity +is_a: GO:0016414 ! O-octanoyltransferase activity + +[Term] +id: GO:0008459 +name: chondroitin 6-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] +synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" RELATED [EC:2.8.2.17] +synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" RELATED [EC:2.8.2.17] +synonym: "chondroitin 6-O-sulfotransferase activity" RELATED [EC:2.8.2.17] +synonym: "chondroitin 6-sulphotransferase activity" EXACT [] +synonym: "terminal 6-sulfotransferase activity" RELATED [EC:2.8.2.17] +xref: EC:2.8.2.17 +xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-2018682 "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains" +xref: Reactome:R-HSA-3595175 "Defective CHST3 does not transfer SO4(2-) to chondroitin" +xref: RHEA:11108 +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0008460 +name: dTDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17221] +synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.46] +synonym: "dTDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.46] +synonym: "dTDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.46] +synonym: "dTDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.46] +synonym: "TDP-glucose oxidoreductase activity" RELATED [EC:4.2.1.46] +synonym: "thymidine diphosphoglucose oxidoreductase activity" RELATED [EC:4.2.1.46] +xref: EC:4.2.1.46 +xref: KEGG_REACTION:R06513 +xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN +xref: RHEA:17221 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008462 +name: obsolete endopeptidase Clp activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP-dependent Clp protease" NARROW [] +synonym: "caseinolytic protease activity" RELATED [] +synonym: "Clp protease" NARROW [] +synonym: "ClpP" RELATED [] +synonym: "endopeptidase Clp activity" EXACT [] +synonym: "endopeptidase Ti activity" RELATED [] +synonym: "protease Ti activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008463 +name: formylmethionine deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate." [EC:3.5.1.31, RHEA:17781] +synonym: "N-formyl-L-methionine amidohydrolase activity" RELATED [EC:3.5.1.31] +xref: EC:3.5.1.31 +xref: KEGG_REACTION:R00653 +xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN +xref: RHEA:17781 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008464 +name: obsolete gamma-glutamyl hydrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] +synonym: "conjugase activity" RELATED [EC:3.4.19.9] +synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] +synonym: "folic acid conjugase activity" RELATED [EC:3.4.19.9] +synonym: "gamma-Glu-X carboxypeptidase activity" RELATED [EC:3.4.19.9] +synonym: "gamma-glutamyl hydrolase activity" EXACT [] +synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] +synonym: "poly(gamma-glutamic acid) endohydrolase activity" RELATED [EC:3.4.19.9] +synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] +synonym: "polyglutamate hydrolase activity" RELATED [EC:3.4.19.9] +synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] +synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" RELATED [EC:3.4.19.9] +synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" RELATED [EC:3.4.19.9] +is_obsolete: true +replaced_by: GO:0008242 + +[Term] +id: GO:0008465 +name: glycerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] +synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] +xref: EC:1.1.1.29 +xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN +xref: RHEA:17905 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008466 +name: glycogenin glucosyltransferase activity +namespace: molecular_function +alt_id: GO:0047210 +def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] +synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] +synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT [] +synonym: "glycogenin activity" RELATED [EC:2.4.1.186] +synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] +synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.186] +synonym: "UDP-glucose:glycogenin glucosyltransferase activity" RELATED [EC:2.4.1.186] +xref: EC:2.4.1.186 +xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-3322003 "Autoglucosylation of GYG1 complexed with GYS1-b" +xref: Reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a" +xref: Reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b" +xref: Reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a" +xref: Reactome:R-HSA-3814838 "Defective GYG1 is not autoglucosyolated" +xref: RHEA:23360 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008467 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] +synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23] +synonym: "3-OST-1 activity" RELATED [EC:2.8.2.23] +synonym: "glucosaminyl 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23] +synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] +synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] +synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] +xref: EC:2.8.2.23 +xref: MetaCyc:2.8.2.23-RXN +xref: Reactome:R-HSA-2076383 "HS3ST1 sulfates GlcN at C3 in heparan sulfate" +xref: Reactome:R-HSA-2076611 "HS3STs sulfate GlcN at C3 in heparan sulfate" +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0008469 +name: histone-arginine N-methyltransferase activity +namespace: molecular_function +alt_id: GO:0016276 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954] +synonym: "histone methyltransferase activity" BROAD [] +synonym: "histone protein methylase activity" EXACT [] +synonym: "histone protein methylase I" RELATED [] +synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] +synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [] +synonym: "protein methylase I activity" BROAD [] +synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [] +xref: Reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)" +xref: Reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)" +xref: Reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)" +xref: Reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3" +xref: Reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter" +xref: Reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter" +xref: Reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter" +xref: Reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter" +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity +is_a: GO:0042054 ! histone methyltransferase activity + +[Term] +id: GO:0008470 +name: isovaleryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.8.4] +synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" RELATED [EC:1.3.8.4] +synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.3.8.4] +synonym: "isovaleroyl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.4] +synonym: "isovaleryl-coenzyme A dehydrogenase activity" RELATED [EC:1.3.8.4] +xref: EC:1.3.8.4 +xref: MetaCyc:ISOVALERYL-COA-FAD-RXN +xref: Reactome:R-HSA-70745 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2" +xref: RHEA:12276 +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0008471 +name: obsolete laccase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] +synonym: "benzenediol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.2] +synonym: "laccase activity" EXACT [] +synonym: "p-diphenol oxidase activity" RELATED [EC:1.10.3.2] +synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] +synonym: "urushiol oxidase activity" RELATED [EC:1.10.3.2] +is_obsolete: true +replaced_by: GO:0016682 + +[Term] +id: GO:0008472 +name: obsolete metallocarboxypeptidase D activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] +synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] +synonym: "metallocarboxypeptidase D activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0008473 +name: ornithine cyclodeaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24368] +comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. +synonym: "L-ornithine ammonia-lyase (cyclizing)" RELATED [EC:4.3.1.12] +synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" RELATED [EC:4.3.1.12] +synonym: "OCD activity" RELATED [EC:4.3.1.12] +synonym: "ornithine cyclase (deaminating) activity" RELATED [EC:4.3.1.12] +synonym: "ornithine cyclase activity" RELATED [EC:4.3.1.12] +xref: EC:4.3.1.12 +xref: KEGG_REACTION:R00671 +xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN +xref: RHEA:24368 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008474 +name: palmitoyl-(protein) hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] +subset: goslim_chembl +synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] +synonym: "palmitoyl-protein hydrolase activity" EXACT [] +synonym: "palmitoyl-protein thioesterase activity" EXACT [] +synonym: "palmitoyl-protein thiolesterase activity" EXACT [] +xref: EC:3.1.2.22 +xref: MetaCyc:3.1.2.22-RXN +xref: Reactome:R-HSA-203613 "depalmitoylation of eNOS" +xref: Reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins" +xref: Reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43" +xref: Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated" +xref: RHEA:19233 +is_a: GO:0016790 ! thiolester hydrolase activity +is_a: GO:0098599 ! palmitoyl hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008475 +name: procollagen-lysine 5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] +synonym: "collagen lysine hydroxylase activity" RELATED [EC:1.14.11.4] +synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] +synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] +synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4] +synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] +synonym: "lysylprotocollagen dioxygenase activity" RELATED [EC:1.14.11.4] +synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.11.4] +synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" RELATED [EC:1.14.11.4] +synonym: "protocollagen lysine dioxygenase activity" RELATED [EC:1.14.11.4] +synonym: "protocollagen lysine hydroxylase activity" RELATED [EC:1.14.11.4] +synonym: "protocollagen lysyl hydroxylase activity" RELATED [EC:1.14.11.4] +xref: EC:1.14.11.4 +xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN +xref: Reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines" +xref: RHEA:16569 +is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity + +[Term] +id: GO:0008476 +name: protein-tyrosine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] +subset: goslim_chembl +synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" RELATED [EC:2.8.2.20] +synonym: "protein-tyrosine sulphotransferase activity" EXACT [] +synonym: "tyrosylprotein sulfotransferase activity" RELATED [EC:2.8.2.20] +xref: EC:2.8.2.20 +xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2" +xref: Reactome:R-HSA-9668023 "TPST1,2 transfer SO4(2-) from PAPS to FVIII" +xref: Reactome:R-HSA-9668148 "F8 variant is not sulfonated at Y1699" +xref: RHEA:16801 +is_a: GO:0008146 ! sulfotransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008477 +name: purine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] +synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] +synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] +synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] +synonym: "N-D-ribosylpurine ribohydrolase activity" RELATED [EC:3.2.2.1] +synonym: "N-ribosyl purine ribohydrolase activity" RELATED [EC:3.2.2.1] +synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] +synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] +synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] +synonym: "purine beta-ribosidase activity" RELATED [EC:3.2.2.1] +synonym: "purine nucleosidase reaction" EXACT [] +synonym: "purine nucleoside hydrolase activity" RELATED [EC:3.2.2.1] +synonym: "purine ribonucleosidase activity" RELATED [EC:3.2.2.1] +synonym: "purine-nucleoside ribohydrolase activity" RELATED [EC:3.2.2.1] +synonym: "purine-specific nucleoside N-ribohydrolase activity" RELATED [EC:3.2.2.1] +synonym: "ribonucleoside hydrolase activity" RELATED [EC:3.2.2.1] +xref: EC:3.2.2.1 +xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN +xref: RHEA:23344 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008478 +name: pyridoxal kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] +synonym: "ATP:pyridoxal 5'-phosphotransferase activity" RELATED [EC:2.7.1.35] +synonym: "pyridoxal 5-phosphate-kinase activity" RELATED [EC:2.7.1.35] +synonym: "pyridoxal kinase (phosphorylating)" RELATED [EC:2.7.1.35] +synonym: "pyridoxal phosphokinase activity" RELATED [EC:2.7.1.35] +synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] +synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] +synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] +synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] +xref: EC:2.7.1.35 +xref: MetaCyc:PYRIDOXKIN-RXN +xref: Reactome:R-HSA-964958 "2xPDXK:2xZn2+ phosphorylates PXA" +xref: Reactome:R-HSA-964962 "2xPDKX:2xZn2+ phosphorylates PDX" +xref: Reactome:R-HSA-964970 "2xPDXK:2xZn2+ phosphorylates PXL" +xref: RHEA:10224 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008479 +name: queuine tRNA-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] +synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" RELATED [EC:2.4.2.29] +synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] +synonym: "guanine, queuine-tRNA transglycosylase activity" RELATED [EC:2.4.2.29] +synonym: "Q-insertase activity" RELATED [EC:2.4.2.29] +synonym: "queuine transfer ribonucleate ribosyltransferase activity" RELATED [EC:2.4.2.29] +synonym: "transfer ribonucleate glycosyltransferase activity" RELATED [EC:2.4.2.29] +synonym: "tRNA guanine transglycosidase activity" RELATED [EC:2.4.2.29] +synonym: "tRNA transglycosylase activity" RELATED [EC:2.4.2.29] +synonym: "tRNA-guanine transglycosylase activity" RELATED [EC:2.4.2.29] +xref: EC:2.4.2.29 +xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)" +xref: RHEA:16633 +is_a: GO:0016763 ! pentosyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0008480 +name: sarcosine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.3, RHEA:19793] +comment: Note that this was EC:1.5.99.1. +synonym: "monomethylglycine dehydrogenase activity" RELATED [EC:1.5.8.3] +synonym: "sarcosine N-demethylase activity" RELATED [EC:1.5.8.3] +synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.8.3] +synonym: "sarcosine:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.8.3] +xref: EC:1.5.8.3 +xref: KEGG_REACTION:R00611 +xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-6797913 "SARDH:FAD oxidatively demethylates SARC to Gly" +xref: RHEA:19793 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor + +[Term] +id: GO:0008481 +name: sphinganine kinase activity +namespace: molecular_function +alt_id: GO:0001728 +def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] +synonym: "ATP:sphinganine 1-phosphotransferase activity" RELATED [EC:2.7.1.91] +synonym: "dihydrosphingosine kinase (phosphorylating)" RELATED [EC:2.7.1.91] +synonym: "dihydrosphingosine kinase activity" RELATED [EC:2.7.1.91] +synonym: "sphingosine kinase (phosphorylating)" RELATED [EC:2.7.1.91] +synonym: "sphingosine kinase activity" RELATED [] +xref: EC:2.7.1.91 +xref: MetaCyc:SPHINGANINE-KINASE-RXN +xref: Reactome:R-HSA-428214 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP" +xref: RHEA:15465 +is_a: GO:0001727 ! lipid kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008482 +name: sulfite oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate." [EC:1.8.3.1, RHEA:24600] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "sulfite:oxygen oxidoreductase activity" RELATED [EC:1.8.3.1] +synonym: "sulphite oxidase activity" EXACT [] +xref: EC:1.8.3.1 +xref: KEGG_REACTION:R00533 +xref: MetaCyc:PWY-5326 +xref: MetaCyc:SULFITE-OXIDASE-RXN +xref: Reactome:R-HSA-1614544 "Sulfite is oxidized to sulfate" +xref: RHEA:24600 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0008483 +name: transaminase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] +synonym: "aminotransferase activity" EXACT [] +xref: EC:2.6.1.- +xref: Reactome:R-HSA-1237102 "Transamination of MOB to methionine" +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0008484 +name: sulfuric ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] +synonym: "sulfatase activity" EXACT [] +synonym: "sulphuric ester hydrolase activity" EXACT [] +xref: EC:3.1.6.- +xref: MetaCyc:ARYLSULFAT-RXN +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0008486 +name: diphosphoinositol-polyphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] +synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" RELATED [EC:3.6.1.52] +synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] +synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" RELATED [EC:3.6.1.52] +synonym: "DIPP activity" RELATED [EC:3.6.1.52] +xref: EC:3.6.1.52 +xref: KEGG_REACTION:R05777 +xref: MetaCyc:3.6.1.52-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008487 +name: obsolete prenyl-dependent CAAX protease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "prenyl-dependent CAAX protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008488 +name: gamma-glutamyl carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194] +xref: EC:4.1.1.90 +xref: Reactome:R-HSA-159752 "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)" +xref: Reactome:R-HSA-159761 "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)" +xref: Reactome:R-HSA-159795 "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)" +xref: Reactome:R-HSA-159803 "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)" +xref: Reactome:R-HSA-159819 "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)" +xref: Reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)" +xref: Reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)" +xref: Reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)" +xref: Reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)" +xref: Reactome:R-HSA-9673231 "GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)" +xref: RHEA:45140 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008489 +name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base." [MetaCyc:RXN-10764, PMID:9593693] +synonym: "LacCer synthase activity" EXACT [] +synonym: "lactosylceramide synthase activity" EXACT [] +synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] +xref: MetaCyc:RXN-10764 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008490 +name: arsenite secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008491 +def: "Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl] +synonym: "arsenite porter activity" RELATED [] +is_a: GO:0015105 ! arsenite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0008492 +name: obsolete cAMP generating peptide activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product. +synonym: "cAMP generating peptide activity" EXACT [] +synonym: "cyclic AMP generating peptide activity" EXACT [] +is_obsolete: true +consider: GO:0004016 +consider: GO:0005179 +consider: GO:0046058 + +[Term] +id: GO:0008493 +name: tetracycline transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators] +synonym: "tetracyclin transporter activity" EXACT [] +synonym: "tetracycline transporter activity" RELATED [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0008494 +name: translation activator activity +namespace: molecular_function +def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] +is_a: GO:0090079 ! translation regulator activity, nucleic acid binding + +[Term] +id: GO:0008495 +name: protoheme IX farnesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate." [RHEA:28070] +synonym: "haem O synthase activity" EXACT [] +synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788] +synonym: "heme O synthase activity" EXACT [] +synonym: "protohaem IX farnesyltransferase activity" EXACT [] +xref: EC:2.5.1.141 +xref: MetaCyc:HEMEOSYN-RXN +xref: Reactome:R-HSA-2995330 "COX10 transforms heme to heme O" +xref: RHEA:28070 +is_a: GO:0004311 ! farnesyltranstransferase activity + +[Term] +id: GO:0008496 +name: mannan endo-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans." [EC:3.2.1.101] +synonym: "1,6-alpha-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.101] +synonym: "1,6-beta-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.101] +synonym: "endo-1,6-beta-mannanase activity" RELATED [EC:3.2.1.101] +synonym: "endo-alpha-1->6-D-mannanase activity" RELATED [EC:3.2.1.101] +synonym: "endo-alpha-D-mannosidase activity" EXACT [] +synonym: "exo-1,6-beta-mannanase activity" RELATED [EC:3.2.1.101] +synonym: "mannan endo-1,6-beta-mannosidase activity" RELATED [EC:3.2.1.101] +xref: EC:3.2.1.101 +xref: MetaCyc:3.2.1.101-RXN +xref: Reactome:R-HSA-6799581 "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man" +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0008498 +name: obsolete phospholipid scrambling +namespace: molecular_function +def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] +comment: This term was made obsolete because it represents a biological process and not a molecular function. +synonym: "phospholipid scrambling" EXACT [] +is_obsolete: true +replaced_by: GO:0017121 + +[Term] +id: GO:0008499 +name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] +synonym: "beta-1,3-GalTase activity" BROAD [] +synonym: "beta3Gal-Ts activity" BROAD [] +synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] +xref: Reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein" +xref: Reactome:R-HSA-9603989 "B3GALTs transfer Gal to GlcNAc-1,3-Gal-R to form Type 1 chain" +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity + +[Term] +id: GO:0008500 +name: obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a conglomeration of three terms. +synonym: "glycine-, glutamate-, thienylcyclohexylpiperidine binding" EXACT [] +is_obsolete: true +consider: GO:0016594 +consider: GO:0016595 +consider: GO:0016596 + +[Term] +id: GO:0008502 +name: melatonin receptor activity +namespace: molecular_function +def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0008503 +name: benzodiazepine receptor activity +namespace: molecular_function +def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0008504 +name: monoamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015201 +def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [GOC:mah] +xref: Reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" +xref: Reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" +xref: Reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" +xref: Reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" +xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol" +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0008506 +name: sucrose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] +synonym: "hydrogen/sucrose transporter activity" BROAD [] +synonym: "sucrose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0009669 ! sucrose:cation symporter activity + +[Term] +id: GO:0008507 +name: sodium:iodide symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] +synonym: "sodium/iodide symporter activity" EXACT [] +xref: Reactome:R-HSA-429591 "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol" +xref: Reactome:R-HSA-5658195 "Defective SLC5A5 does not cotransport Na+ with I- from extracellular region to cytosol" +is_a: GO:0015111 ! iodide transmembrane transporter activity +is_a: GO:0015373 ! anion:sodium symporter activity + +[Term] +id: GO:0008508 +name: bile acid:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] +synonym: "sodium/bile acid symporter activity" EXACT [] +xref: Reactome:R-HSA-194121 "Co-transport (influx) of bile salts and sodium ions by NTCP" +xref: Reactome:R-HSA-194187 "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-433089 "SOAT can transport taurolithocholate-3-sulphate" +is_a: GO:0015125 ! bile acid transmembrane transporter activity +is_a: GO:0140161 ! monocarboxylate:sodium symporter activity + +[Term] +id: GO:0008509 +name: anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "anion transporter activity" EXACT [] +xref: Reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface" +is_a: GO:0015075 ! ion transmembrane transporter activity + +[Term] +id: GO:0008510 +name: sodium:bicarbonate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] +synonym: "sodium/bicarbonate cotransporter activity" BROAD [] +synonym: "sodium:bicarbonate cotransporter activity" BROAD [] +xref: Reactome:R-HSA-425483 "SLC4A5,7,9 cotransport Na+ with 3HCO3-" +xref: Reactome:R-HSA-5656219 "Defective SLC4A4 does not cotransport Na+ with 3HCO3-" +xref: Reactome:R-HSA-8878664 "SLC4A4 cotransports Na+ with 3HCO3-" +is_a: GO:0015370 ! solute:sodium symporter activity +is_a: GO:0140410 ! solute:bicarbonate symporter activity + +[Term] +id: GO:0008511 +name: sodium:potassium:chloride symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] +synonym: "sodium/potassium/chloride symporter activity" EXACT [] +xref: Reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol" +xref: Reactome:R-HSA-5623588 "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol" +is_a: GO:0009674 ! potassium:sodium symporter activity +is_a: GO:0015378 ! sodium:chloride symporter activity +is_a: GO:0015379 ! potassium:chloride symporter activity + +[Term] +id: GO:0008512 +name: sulfate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] +synonym: "sulfate/hydrogen symporter activity" EXACT [] +synonym: "sulfate:hydrogen symporter activity" EXACT [] +synonym: "sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0008513 +name: secondary active organic cation transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015354 +def: "Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators] +synonym: "organic cation porter activity" RELATED [] +synonym: "polyspecific organic cation transmembrane transporter activity" NARROW [] +xref: Reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol" +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0008514 +name: organic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] +xref: Reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:0008515 +name: sucrose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019188 +def: "Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "sucrose permease (PTS) activity" EXACT [] +synonym: "sucrose permease activity" RELATED [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0008516 +name: hexose uniporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] +is_a: GO:0015149 ! hexose transmembrane transporter activity +is_a: GO:0015292 ! uniporter activity + +[Term] +id: GO:0008517 +name: folic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] +synonym: "folate transmembrane transporter activity" EXACT [] +synonym: "folate transporter activity" EXACT [] +synonym: "folic acid transporter activity" RELATED [] +synonym: "vitamin B9 transporter activity" EXACT [] +synonym: "vitamin M transporter activity" EXACT [] +xref: Reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane" +xref: Reactome:R-HSA-200652 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane" +xref: Reactome:R-HSA-200680 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane" +xref: Reactome:R-HSA-200720 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane" +xref: Reactome:R-HSA-200729 "Extracellular folate import across the plasma membrane" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0008518 +name: folate:anion antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF." [GOC:mtg_transport, PMID:21568705, PMID:24745983, TC:2.A.48] +synonym: "reduced folate carrier activity" RELATED [] +synonym: "reduced folate transmembrane transporter activity" RELATED [] +synonym: "reduced folate transporter" RELATED [] +xref: TC:2.A.48 +is_a: GO:0008517 ! folic acid transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0008519 +name: ammonium transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015251 +alt_id: GO:0051739 +def: "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [PMID:17710640] +synonym: "ammonia transmembrane transporter activity" RELATED [] +synonym: "ammonium channel activity" RELATED [] +xref: Reactome:R-HSA-444393 "RhCG mediates ammonium influx into kidney collecting duct cells" +xref: Reactome:R-HSA-444416 "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)" +xref: Reactome:R-HSA-444419 "RhBG mediates ammonium effflux out of kidney collecting duct cells" +xref: Reactome:R-HSA-446277 "RhCG mediates ammonium efflux out of kidney collecting duct cells" +xref: Reactome:R-HSA-446278 "RhBG mediates ammonium influx into kidney collecting duct cells" +xref: Reactome:R-HSA-5623051 "Defective RHAG does not transport NH4+ from cytosol to extracellular region (rbc)" +xref: RHEA:28747 +xref: TCBD:1.A.11 +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0008520 +name: L-ascorbate:sodium symporter activity +namespace: molecular_function +alt_id: GO:0070890 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in)." [GOC:mah, GOC:yaf, PMID:18094143] +synonym: "sodium-dependent L-ascorbate transmembrane transporter activity" RELATED [] +synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] +xref: TC:2.A.40.6.1 +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0008521 +name: acetyl-CoA transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] +synonym: "acetyl-CoA transporter activity" RELATED [] +xref: Reactome:R-HSA-5649742 "Defective SLC33A1 does not transport Ac-CoA from cytosol to Golgi lumen" +xref: Reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0008523 +name: sodium-dependent multivitamin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] +xref: Reactome:R-HSA-199206 "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol" +xref: Reactome:R-HSA-199219 "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol" +xref: Reactome:R-HSA-429581 "SLC5A6 transports vitamins from extracellular region to cytosol" +is_a: GO:0015370 ! solute:sodium symporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0008525 +name: phosphatidylcholine transporter activity +namespace: molecular_function +def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732] +synonym: "phosphatidylcholine transmembrane transporter activity" NARROW [GOC:bf, GOC:vw] +is_a: GO:0005548 ! phospholipid transporter activity + +[Term] +id: GO:0008526 +name: phosphatidylinositol transfer activity +namespace: molecular_function +alt_id: GO:0120018 +def: "Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane phosphatidylinositol transfer activity" NARROW [] +synonym: "intermembrane phosphotidylinositol transfer activity" NARROW [] +synonym: "phosphatidylinositol carrier activity" EXACT [] +synonym: "phosphatidylinositol transporter activity" BROAD [] +xref: Reactome:R-HSA-8869241 "PITPNM1,2,3 exchange PI for PA" +xref: Reactome:R-HSA-8874470 "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane" +is_a: GO:0120014 ! phospholipid transfer activity + +[Term] +id: GO:0008527 +name: taste receptor activity +namespace: molecular_function +def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] +synonym: "gustatory receptor" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0008528 +name: G protein-coupled peptide receptor activity +namespace: molecular_function +def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] +synonym: "G protein coupled peptide receptor activity" EXACT [] +synonym: "G-protein coupled peptide receptor activity" EXACT [] +synonym: "peptide receptor activity, G protein coupled" EXACT [] +synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0001653 ! peptide receptor activity +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0008529 +name: obsolete endogenous peptide receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "endogenous peptide receptor activity" EXACT [] +is_obsolete: true +consider: GO:0001653 +consider: GO:0005622 + +[Term] +id: GO:0008530 +name: obsolete exogenous peptide receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "exogenous peptide receptor activity" EXACT [] +is_obsolete: true +consider: GO:0001653 +consider: GO:0005576 + +[Term] +id: GO:0008531 +name: riboflavin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14357] +synonym: "ATP:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.26] +synonym: "FK" RELATED [EC:2.7.1.26] +synonym: "flavokinase activity" RELATED [EC:2.7.1.26] +synonym: "riboflavin kinase (phosphorylating)" RELATED [EC:2.7.1.26] +synonym: "riboflavine kinase activity" RELATED [EC:2.7.1.26] +xref: EC:2.7.1.26 +xref: KEGG_REACTION:R00549 +xref: MetaCyc:RIBOFLAVINKIN-RXN +xref: Reactome:R-HSA-196964 "RFK:Mg2+ phosphorylates RIB" +xref: RHEA:14357 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008532 +name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] +synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "GnTE activity" RELATED [EC:2.4.1.149] +synonym: "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] +synonym: "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.149] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] +xref: EC:2.4.1.149 +xref: MetaCyc:2.4.1.149-RXN +xref: Reactome:R-HSA-2025724 "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG" +xref: RHEA:14389 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008533 +name: obsolete astacin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "astacin activity" EXACT [] +synonym: "Astacus proteinase activity" RELATED [] +synonym: "astacus proteinase activity" NARROW [] +synonym: "crayfish small-molecule proteinase activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008534 +name: oxidized purine nucleobase lesion DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0003907 +def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] +comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. +synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23] +synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" RELATED [EC:3.2.2.23] +synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] +synonym: "bifunctional DNA glycosylase activity" BROAD [] +synonym: "deoxyribonucleate glycosidase activity" RELATED [EC:3.2.2.23] +synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] +synonym: "DNA glycosylase/AP-lyase activity" BROAD [] +synonym: "DNA glycosylase/beta-lyase activity" BROAD [] +synonym: "DNA-formamidopyrimidine glycosylase activity" RELATED [] +synonym: "Fapy-DNA glycosylase activity" RELATED [EC:3.2.2.23] +synonym: "formamidopyrimidine-DNA glycosylase activity" RELATED [] +synonym: "Fpg protein" RELATED [EC:3.2.2.23] +synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT [] +synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] +xref: EC:3.2.2.23 +xref: MetaCyc:3.2.2.23-RXN +xref: Reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase" +xref: Reactome:R-HSA-110243 "Excision of 8-oxoguanine by OGG1 glycosylase" +xref: Reactome:R-HSA-110244 "Excision of FapyG by OGG1 glycosylase" +is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity + +[Term] +id: GO:0008535 +name: respiratory chain complex IV assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] +synonym: "cytochrome c oxidase biogenesis" BROAD [] +synonym: "cytochrome c oxidase complex assembly" EXACT [] +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0008537 +name: proteasome activator complex +namespace: cellular_component +def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] +synonym: "PA28" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0008538 +name: obsolete proteasome activator activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] +comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. +synonym: "PA28" NARROW [] +synonym: "proteasome activator activity" EXACT [] +is_obsolete: true +consider: GO:0061133 +consider: GO:0061136 + +[Term] +id: GO:0008539 +name: obsolete proteasome inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah] +comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. +synonym: "PI-31" NARROW [] +synonym: "proteasome inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0004866 +consider: GO:0061136 + +[Term] +id: GO:0008540 +name: proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005838 ! proteasome regulatory particle + +[Term] +id: GO:0008541 +name: proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005838 ! proteasome regulatory particle + +[Term] +id: GO:0008542 +name: visual learning +namespace: biological_process +def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] +synonym: "spatial learning" RELATED [] +is_a: GO:0007632 ! visual behavior +is_a: GO:0008306 ! associative learning + +[Term] +id: GO:0008543 +name: fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "FGF receptor signaling pathway" EXACT [] +synonym: "FGF receptor signalling pathway" EXACT [] +synonym: "FGFR signaling pathway" EXACT [] +synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus + +[Term] +id: GO:0008544 +name: epidermis development +namespace: biological_process +def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] +synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0008545 +name: JUN kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] +synonym: "JNKK" EXACT [] +xref: Reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7" +is_a: GO:0004708 ! MAP kinase kinase activity + +[Term] +id: GO:0008546 +name: obsolete microtubule/chromatin interaction +namespace: biological_process +def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] +comment: This term was made obsolete because it represents a molecular function. +synonym: "microtubule/chromatin interaction" EXACT [] +is_obsolete: true +consider: GO:0003677 +consider: GO:0003682 +consider: GO:0008017 +consider: GO:0030674 + +[Term] +id: GO:0008547 +name: obsolete protein-synthesizing GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "protein-synthesizing GTPase activity" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0006412 +consider: GO:0008135 + +[Term] +id: GO:0008548 +name: obsolete signal-recognition-particle GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "signal-recognition-particle GTPase activity" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0005786 + +[Term] +id: GO:0008549 +name: obsolete dynamin GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "dynamin GTPase activity" EXACT [] +synonym: "dynamine GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0006897 + +[Term] +id: GO:0008550 +name: obsolete tubulin GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "tubulin GTPase activity" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0007021 + +[Term] +id: GO:0008551 +name: P-type cadmium transporter activity +namespace: molecular_function +alt_id: GO:0008561 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out)." [PMID:17326661] +synonym: "cadmium exporting ATPase activity" EXACT [] +synonym: "cadmium transmembrane transporter activity, phosphorylative mechanism" RELATED [] +synonym: "cadmium-exporting ATPase activity" NARROW [] +synonym: "cadmium-translocating P-type ATPase activity" EXACT [EC:7.2.2.21] +synonym: "Cd(2+)-exporting ATPase activity" RELATED [EC:7.2.2.21] +synonym: "Cd2+-exporting ATPase activity" RELATED [EC:7.2.2.21] +xref: EC:7.2.2.21 +xref: MetaCyc:3.6.3.3-RXN +xref: RHEA:12132 +is_a: GO:0015086 ! cadmium ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0008552 +name: obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] +comment: This term was made obsolete because it represents more than one molecular function. +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0005385 +consider: GO:0015086 +consider: GO:0015087 +consider: GO:0015094 +consider: GO:0015099 +consider: GO:0015662 + +[Term] +id: GO:0008553 +name: P-type proton-exporting transporter activity +namespace: molecular_function +alt_id: GO:0036442 +def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [RHEA:20852] +synonym: "H(+)-transporting ATPase activity" BROAD [EC:7.1.2.1] +synonym: "H+-exporting ATPase activity" RELATED [EC:7.1.2.1] +synonym: "H+-transporting ATPase" BROAD [EC:7.1.2.1] +synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] +synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] +synonym: "hydrogen-exporting ATPase activity" BROAD [] +synonym: "hydrogen-exporting ATPase activity, phosphorylative mechanism" RELATED [] +synonym: "P-type H(+)-exporting ATPase activity" BROAD [EC:7.1.2.1] +synonym: "proton transport ATPase activity" RELATED [EC:7.1.2.1] +synonym: "proton-exporting ATPase activity" BROAD [] +synonym: "proton-exporting ATPase activity, phosphorylative mechanism" RELATED [] +synonym: "proton-translocating ATPase activity" RELATED [EC:7.1.2.1] +synonym: "proton-transporting ATPase activity" EXACT [GOC:bf] +xref: EC:7.1.2.1 +xref: MetaCyc:3.6.3.6-RXN +xref: RHEA:20852 +is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0008554 +name: P-type sodium transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism." [PMID:9224683] +comment: Note that RHEA:14633 represents both the ABC and the P-type sodium transporters. +synonym: "Na(+)-exporting ATPase activity" BROAD [EC:7.2.2.3] +synonym: "Na(+)-transporting ATPase activity" BROAD [EC:7.2.2.3] +synonym: "Na+-exporting ATPase activity" BROAD [EC:7.2.2.3] +synonym: "Na+-transporting ATPase activity" BROAD [EC:7.2.2.3] +synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] +synonym: "sodium transmembrane transporter activity, phosphorylative mechanism" EXACT [] +synonym: "sodium transport ATPase activity" BROAD [EC:7.2.2.3] +synonym: "sodium-exporting ATPase activity" BROAD [EC:7.2.2.3] +synonym: "sodium-exporting ATPase activity, phosphorylative mechanism" EXACT [] +synonym: "sodium-translocating P-type ATPase activity" EXACT [EC:7.2.2.3] +xref: EC:7.2.2.3 +xref: MetaCyc:3.6.3.7-RXN +xref: RHEA:14633 +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0008556 +name: P-type potassium transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015618 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [RHEA:16777] +synonym: "ATP phosphohydrolase (K+-importing)" RELATED [EC:7.2.2.6] +synonym: "ATP-dependent potassium transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled potassium transmembrane transporter activity" RELATED [] +synonym: "K(+)-importing ATPase activity" NARROW [EC:7.2.2.6] +synonym: "K(+)-transporting ATPase activity" RELATED [EC:7.2.2.6] +synonym: "K+-importing ATPase activity" RELATED [EC:7.2.2.6] +synonym: "K+-transporting ATPase activity" EXACT [] +synonym: "potassium ABC transporter" NARROW [] +synonym: "potassium transmembrane transporter activity, phosphorylative mechanism" EXACT [] +synonym: "potassium transporting ATPase activity" EXACT [] +synonym: "potassium-importing ATPase activity" NARROW [EC:7.2.2.6] +synonym: "potassium-transporting ATPase activity" EXACT [] +synonym: "potassium-uptake-ATPase activity" EXACT [] +xref: EC:7.2.2.6 +xref: RHEA:16777 +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0008558 +name: ABC-type guanine transporter activity +namespace: molecular_function +def: "Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [RHEA:20832] +synonym: "ATP-dependent guanine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled guanine transmembrane transporter activity" RELATED [] +synonym: "guanine ABC transporter" EXACT [] +synonym: "guanine-transporting ATPase activity" RELATED [EC:7.6.2.6] +xref: EC:7.6.2.6 +xref: MetaCyc:3.6.3.37-RXN +xref: RHEA:20832 +is_a: GO:0015208 ! guanine transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0008559 +name: ABC-type xenobiotic transporter activity +namespace: molecular_function +alt_id: GO:0005226 +alt_id: GO:0008560 +def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:7.6.2.2] +synonym: "ATP phosphohydrolase (xenobiotic-exporting)" RELATED [EC:7.6.2.2] +synonym: "ATP-dependent xenobiotic transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled xenobiotic transmembrane transporter activity" RELATED [] +synonym: "MDR protein" RELATED [EC:7.6.2.2] +synonym: "multidrug resistance exporter" RELATED [] +synonym: "multidrug-resistance protein" RELATED [] +synonym: "P-glycoprotein" RELATED [EC:7.6.2.2] +synonym: "PDR protein" RELATED [EC:7.6.2.2] +synonym: "pleiotropic-drug-resistance protein" RELATED [EC:7.6.2.2] +synonym: "xenobiotic ABC transporter" NARROW [] +synonym: "xenobiotic transmembrane transporting ATPase activity" EXACT [] +xref: EC:7.6.2.2 +xref: MetaCyc:3.6.3.44-RXN +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0008563 +name: obsolete alpha-factor sex pheromone exporter +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] +comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. +synonym: "alpha-factor sex pheromone exporter" EXACT [] +synonym: "alpha-factor-transporting ATPase" RELATED [] +is_obsolete: true + +[Term] +id: GO:0008564 +name: protein-exporting ATPase activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins." [PMID:30346996] +comment: Represents ATP- hydrolyzing enzymes of the general secretory pathway (Sec or Type II), of the virulence-related secretory pathway (Type III) and of the conjugal DNA-protein transfer pathway (Type IV). Type II enzymes occur in bacteria, archaea and eukaryotes, whereas type III and type IV enzymes occur in bacteria where they form components of a multi-subunit complex. +synonym: "ATPase-coupled protein transporter activity" EXACT [] +xref: EC:7.4.2.8 +xref: MetaCyc:3.6.3.50-RXN +is_a: GO:0015450 ! protein-transporting ATPase activity + +[Term] +id: GO:0008565 +name: obsolete protein transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] +comment: This term was obsoleted because is has been inconsistently used. +synonym: "enzyme transporter activity" NARROW [] +synonym: "holin" RELATED [] +synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] +synonym: "secretin" RELATED [] +is_obsolete: true + +[Term] +id: GO:0008566 +name: mitochondrial protein-transporting ATPase activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:7.4.2.3] +comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. +synonym: "ATPase-coupled mitochondrial protein transporter activity" EXACT [] +xref: EC:7.4.2.3 +xref: MetaCyc:3.6.3.51-RXN +is_a: GO:0015450 ! protein-transporting ATPase activity + +[Term] +id: GO:0008567 +name: obsolete dynein ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +synonym: "dynein ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0003777 +consider: GO:0007018 + +[Term] +id: GO:0008568 +name: microtubule-severing ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:5.6.1.1, PMID:10910766] +comment: See also the cellular component term 'katanin complex ; GO:0008352'. +synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [] +synonym: "katanin activity" NARROW [EC:5.6.1.1] +xref: EC:5.6.1.1 +xref: MetaCyc:3.6.4.3-RXN +xref: Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites" +is_a: GO:0140096 ! catalytic activity, acting on a protein +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0008569 +name: minus-end-directed microtubule motor activity +namespace: molecular_function +def: "A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis." [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864] +synonym: "ATP-dependent microtubule motor activity, minus-end-directed" EXACT [] +synonym: "ATP-dependent minus-end-directed microtubule motor activity" EXACT [] +synonym: "dynein ATPase" NARROW [] +synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" NARROW [] +synonym: "microtubule motor activity, minus-end-directed" EXACT [] +synonym: "minus-end-directed ATP-dependent microtubule motor activity" EXACT [] +synonym: "minus-end-directed kinesin ATPase activity" NARROW [] +xref: MetaCyc:3.6.4.5-RXN +is_a: GO:0003777 ! microtubule motor activity + +[Term] +id: GO:0008570 +name: obsolete myosin ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +synonym: "myosin ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0000146 +consider: GO:0030048 + +[Term] +id: GO:0008571 +name: obsolete non-chaperonin molecular chaperone ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "non-chaperonin molecular chaperone ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016887 +consider: GO:0006457 + +[Term] +id: GO:0008572 +name: obsolete nucleoplasmin ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] +comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. +synonym: "nucleoplasmin ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016887 +consider: GO:0006333 + +[Term] +id: GO:0008573 +name: obsolete peroxisome-assembly ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] +comment: This term was made obsolete because it incorporates process information. +synonym: "peroxisome-assembly ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016887 +consider: GO:0007031 + +[Term] +id: GO:0008574 +name: plus-end-directed microtubule motor activity +namespace: molecular_function +def: "A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis." [GOC:vw, PMID:32842864] +synonym: "ATP-dependent microtubule motor activity, plus-end-directed" EXACT [] +synonym: "ATP-dependent plus-end-directed microtubule motor activity" EXACT [] +synonym: "kinesin activity" RELATED [EC:5.6.1.3] +synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" NARROW [] +synonym: "microtubule motor activity, plus-end-directed" EXACT [] +synonym: "plus-end-directed ATP-dependent microtubule motor activity" EXACT [] +synonym: "plus-end-directed kinesin ATPase activity" NARROW [] +xref: EC:5.6.1.3 +xref: MetaCyc:3.6.4.4-RXN +is_a: GO:0003777 ! microtubule motor activity + +[Term] +id: GO:0008575 +name: obsolete proteasome ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] +comment: This term was made obsolete because it mentions a component term in the term text string. +synonym: "proteasome ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0016887 + +[Term] +id: GO:0008576 +name: obsolete vesicle-fusing ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] +comment: This term was made obsolete because it incorporates process information. +synonym: "vesicle-fusing ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016887 +consider: GO:0016192 +consider: GO:0061025 + +[Term] +id: GO:0008579 +name: JUN kinase phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] +is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity + +[Term] +id: GO:0008580 +name: obsolete cytoskeletal regulator activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. +synonym: "cytoskeletal regulator activity" EXACT [] +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0008581 +name: obsolete ubiquitin-specific protease 5 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] +comment: This term was made obsolete because it represents a gene product. +synonym: "ubiquitin isopeptidase T activity" EXACT [] +synonym: "ubiquitin-specific protease 5 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004843 + +[Term] +id: GO:0008582 +name: regulation of synaptic assembly at neuromuscular junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions." [GOC:go_curators] +synonym: "regulation of synaptic growth at neuromuscular junction" RELATED [] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051963 ! regulation of synapse assembly +is_a: GO:1904396 ! regulation of neuromuscular junction development +relationship: regulates GO:0051124 ! synaptic assembly at neuromuscular junction + +[Term] +id: GO:0008583 +name: mystery cell differentiation +namespace: biological_process +def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0008584 +name: male gonad development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] +synonym: "testicular development" EXACT [GOC:sl] +synonym: "testis development" EXACT [GOC:sl] +is_a: GO:0008406 ! gonad development +relationship: part_of GO:0046546 ! development of primary male sexual characteristics + +[Term] +id: GO:0008585 +name: female gonad development +namespace: biological_process +alt_id: GO:0061039 +def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] +synonym: "ovarian development" RELATED [GOC:sl] +synonym: "ovary development" RELATED [GOC:sl] +is_a: GO:0008406 ! gonad development +relationship: part_of GO:0046545 ! development of primary female sexual characteristics + +[Term] +id: GO:0008586 +name: imaginal disc-derived wing vein morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] +synonym: "wing vein morphogenesis" EXACT [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0008587 +name: imaginal disc-derived wing margin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] +comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. +synonym: "wing margin morphogenesis" EXACT [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0008589 +name: regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0007226 +alt_id: GO:0043109 +def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "regulation of smoothened activity" RELATED [] +synonym: "regulation of smoothened by patched" RELATED [] +synonym: "regulation of smoothened receptor activity by patched" RELATED [] +synonym: "regulation of smoothened signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0008591 +name: regulation of Wnt signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "regulation of frizzled-2 signalling pathway" EXACT [] +synonym: "regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] +synonym: "regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway + +[Term] +id: GO:0008592 +name: regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "regulation of Tl signaling pathway" EXACT [] +synonym: "regulation of Tl signalling pathway" EXACT [] +synonym: "regulation of Toll signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0008593 +name: regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "regulation of N signaling pathway" EXACT [] +synonym: "regulation of N signalling pathway" EXACT [] +synonym: "regulation of Notch signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0008594 +name: photoreceptor cell morphogenesis +namespace: biological_process +def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] +synonym: "photoreceptor development" RELATED [] +is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation +relationship: part_of GO:0042461 ! photoreceptor cell development + +[Term] +id: GO:0008595 +name: anterior/posterior axis specification, embryo +namespace: biological_process +def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] +synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0009948 ! anterior/posterior axis specification +relationship: part_of GO:0007351 ! tripartite regional subdivision + +[Term] +id: GO:0008597 +name: calcium-dependent protein serine/threonine phosphatase regulator activity +namespace: molecular_function +def: "Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [GOC:ai] +synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] +xref: Reactome:R-HSA-139906 "Activation of BAD by calcineurin" +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0008603 +name: cAMP-dependent protein kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] +synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] +synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] +synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] +synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0008605 +name: obsolete protein kinase CK2 regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "casein kinase II, regulator" EXACT [] +synonym: "protein kinase CK2 regulator activity" EXACT [] +synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] +is_obsolete: true +replaced_by: GO:0019887 + +[Term] +id: GO:0008607 +name: phosphorylase kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme phosphorylase kinase." [GOC:curators] +synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0008608 +name: attachment of spindle microtubules to kinetochore +namespace: biological_process +alt_id: GO:0051313 +def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] +comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation). +synonym: "amphotelic attachment" RELATED [] +synonym: "attachment of spindle microtubules to chromosome" EXACT [] +synonym: "bipolar attachment" RELATED [] +synonym: "kinetochore microtubule interaction" BROAD [] +synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "kinetochore-microtubule interaction" BROAD [] +synonym: "microtubule anchoring at kinetochore" EXACT [] +synonym: "microtubule and chromosome interaction" BROAD [] +synonym: "microtubule and kinetochore interaction" RELATED [] +synonym: "microtubule capture" NARROW [] +synonym: "spindle chromosome attachment" EXACT [] +synonym: "spindle kinetochore attachment" EXACT [] +synonym: "spindle-chromosome interaction" BROAD [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0008609 +name: alkylglycerone-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] +synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" RELATED [EC:2.5.1.26] +synonym: "alkyl DHAP synthetase activity" RELATED [EC:2.5.1.26] +synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] +synonym: "alkyl-DHAP synthase activity" RELATED [EC:2.5.1.26] +synonym: "alkyldihydroxyacetone phosphate synthetase activity" RELATED [EC:2.5.1.26] +synonym: "alkyldihydroxyacetonephosphate synthase activity" RELATED [EC:2.5.1.26] +synonym: "DHAP-AT" RELATED [EC:2.5.1.26] +synonym: "dihydroxyacetone-phosphate acyltransferase activity" RELATED [EC:2.5.1.26] +xref: EC:2.5.1.26 +xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN +xref: Reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate" +xref: RHEA:36171 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008610 +name: lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] +synonym: "lipid anabolism" EXACT [] +synonym: "lipid biosynthesis" EXACT [] +synonym: "lipid formation" EXACT [] +synonym: "lipid synthesis" EXACT [] +synonym: "lipogenesis" EXACT [GOC:sl] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0008611 +name: ether lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] +synonym: "ether lipid anabolism" EXACT [] +synonym: "ether lipid biosynthesis" EXACT [] +synonym: "ether lipid formation" EXACT [] +synonym: "ether lipid synthesis" EXACT [] +synonym: "plasmalogen biosynthetic process" NARROW [] +is_a: GO:0046485 ! ether lipid metabolic process +is_a: GO:0046504 ! glycerol ether biosynthetic process +is_a: GO:0097384 ! cellular lipid biosynthetic process + +[Term] +id: GO:0008612 +name: peptidyl-lysine modification to peptidyl-hypusine +namespace: biological_process +alt_id: GO:0046515 +def: "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] +synonym: "hypusine anabolism" EXACT [] +synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] +synonym: "hypusine biosynthesis" EXACT [] +synonym: "hypusine biosynthetic process" EXACT [] +synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] +synonym: "hypusine formation" EXACT [] +synonym: "hypusine formation from peptidyl-lysine" EXACT [] +synonym: "hypusine synthesis" EXACT [] +synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] +synonym: "hypusinylation" EXACT [] +synonym: "protein hypusination" EXACT [] +xref: RESID:AA0116 +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0008613 +name: diuretic hormone activity +namespace: molecular_function +def: "The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0008614 +name: pyridoxine metabolic process +namespace: biological_process +alt_id: GO:0006773 +def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:curators] +synonym: "pyridoxine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0008615 +name: pyridoxine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] +synonym: "pyridoxine anabolism" EXACT [] +synonym: "pyridoxine biosynthesis" EXACT [] +synonym: "pyridoxine formation" EXACT [] +synonym: "pyridoxine synthesis" EXACT [] +is_a: GO:0008614 ! pyridoxine metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0008616 +name: queuosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732] +synonym: "queuosine anabolism" EXACT [] +synonym: "queuosine biosynthesis" EXACT [] +synonym: "queuosine formation" EXACT [] +synonym: "queuosine synthesis" EXACT [] +is_a: GO:0042455 ! ribonucleoside biosynthetic process +is_a: GO:0046116 ! queuosine metabolic process + +[Term] +id: GO:0008617 +name: guanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732] +synonym: "guanosine metabolism" EXACT [] +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:0008618 +name: 7-methylguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] +synonym: "7-methylguanosine metabolism" EXACT [] +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:0008619 +name: obsolete RHEB small monomeric GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] +comment: This term was made obsolete because it represents a gene product. +synonym: "RHEB small monomeric GTPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003924 +consider: GO:0001558 +consider: GO:0051726 + +[Term] +id: GO:0008622 +name: epsilon DNA polymerase complex +namespace: cellular_component +def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] +synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0008623 +name: CHRAC +namespace: cellular_component +alt_id: GO:0016588 +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192] +synonym: "chromatin accessibility complex" EXACT [] +synonym: "ISW2 complex" NARROW [] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0008625 +name: extrinsic apoptotic signaling pathway via death domain receptors +namespace: biological_process +def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] +comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013. +synonym: "death receptor-mediated apoptosis" NARROW [] +synonym: "induction of apoptosis via death domain receptors" RELATED [] +synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah] +is_a: GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:0008626 +name: granzyme-mediated apoptotic signaling pathway +namespace: biological_process +def: "A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [GOC:mtg_apoptosis, PMID:17158907] +synonym: "apoptotic signaling pathway in response to granzyme" RELATED [] +synonym: "induction of apoptosis by granzyme" RELATED [] +is_a: GO:0097190 ! apoptotic signaling pathway +is_a: GO:0140507 ! granzyme-mediated programmed cell death signaling pathway + +[Term] +id: GO:0008627 +name: intrinsic apoptotic signaling pathway in response to osmotic stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738] +synonym: "induction of apoptosis by ionic changes" RELATED [] +is_a: GO:0071470 ! cellular response to osmotic stress +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:0008628 +name: hormone-mediated apoptotic signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:mtg_apoptosis] +comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use. +synonym: "apoptotic signaling pathway in response to hormone" RELATED [] +synonym: "induction of apoptosis by hormones" RELATED [] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0008630 +name: intrinsic apoptotic signaling pathway in response to DNA damage +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [] +is_a: GO:0006974 ! cellular response to DNA damage stimulus +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:0008631 +name: intrinsic apoptotic signaling pathway in response to oxidative stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] +synonym: "induction of apoptosis by oxidative stress" RELATED [] +synonym: "oxidative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway +relationship: part_of GO:0036473 ! cell death in response to oxidative stress + +[Term] +id: GO:0008633 +name: obsolete activation of pro-apoptotic gene products +namespace: biological_process +def: "OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah, GOC:mtg_apoptosis] +comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition). +synonym: "activation of pro-apoptotic gene products" EXACT [] +synonym: "induction of pro-apoptotic gene products" RELATED [] +is_obsolete: true + +[Term] +id: GO:0008634 +name: obsolete negative regulation of survival gene product expression +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] +comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. +synonym: "down regulation of survival gene product activity" BROAD [] +synonym: "down-regulation of survival gene product activity" BROAD [] +synonym: "downregulation of survival gene product activity" BROAD [] +synonym: "inhibition of survival gene product activity" NARROW [] +synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] +synonym: "negative regulation of survival gene product expression" EXACT [] +synonym: "negative regulation of survival gene products" BROAD [] +is_obsolete: true + +[Term] +id: GO:0008635 +name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase] +synonym: "activation of caspase activity by cytochrome c" NARROW [] +synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:0008636 +name: obsolete activation of caspase activity by protein phosphorylation +namespace: biological_process +def: "OBSOLETE. Upregulation of the activity of a caspase, a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] +comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage). +synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf] +synonym: "activation of caspase activity by protein phosphorylation" EXACT [] +synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0008637 +name: apoptotic mitochondrial changes +namespace: biological_process +def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] +comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it. +is_a: GO:0007005 ! mitochondrion organization +relationship: part_of GO:0006915 ! apoptotic process + +[Term] +id: GO:0008638 +name: obsolete protein tagging activity +namespace: molecular_function +def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] +comment: This term was made obsolete because it represents a biological process and a molecular function. +synonym: "protein tagging activity" EXACT [] +is_obsolete: true +consider: GO:0005515 +consider: GO:0006464 +consider: GO:0031386 + +[Term] +id: GO:0008641 +name: ubiquitin-like modifier activating enzyme activity +namespace: molecular_function +alt_id: GO:0008642 +def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "small protein activating enzyme activity" NARROW [] +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008643 +name: carbohydrate transport +namespace: biological_process +alt_id: GO:0006861 +alt_id: GO:0008644 +def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] +subset: goslim_pir +subset: goslim_yeast +synonym: "sugar transport" NARROW [] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0008645 +name: hexose transmembrane transport +namespace: biological_process +alt_id: GO:0008646 +alt_id: GO:0008647 +alt_id: GO:0035428 +def: "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "hexose membrane transport" RELATED [] +synonym: "hexose transport" RELATED [] +synonym: "high-affinity hexose transport" NARROW [] +synonym: "low-affinity hexose transport" NARROW [] +is_a: GO:0015749 ! monosaccharide transmembrane transport + +[Term] +id: GO:0008648 +name: obsolete tachykinin +namespace: molecular_function +def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732, ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +synonym: "tachykinin" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0042311 +consider: GO:0045987 +consider: GO:0046878 + +[Term] +id: GO:0008649 +name: rRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0140102 ! catalytic activity, acting on a rRNA + +[Term] +id: GO:0008650 +name: rRNA (uridine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] +xref: Reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine" +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0008651 +name: obsolete actin polymerizing activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +synonym: "actin polymerizing activity" EXACT [] +is_obsolete: true +consider: GO:0030041 +consider: GO:0042802 + +[Term] +id: GO:0008652 +name: cellular amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] +synonym: "amino acid biosynthetic process" EXACT [] +synonym: "cellular amino acid anabolism" EXACT [] +synonym: "cellular amino acid biosynthesis" EXACT [] +synonym: "cellular amino acid formation" EXACT [] +synonym: "cellular amino acid synthesis" EXACT [] +xref: Wikipedia:Amino_acid_synthesis +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0008653 +name: lipopolysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732] +synonym: "lipopolysaccharide metabolism" EXACT [] +synonym: "LPS metabolic process" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:1903509 ! liposaccharide metabolic process + +[Term] +id: GO:0008654 +name: phospholipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] +synonym: "phospholipid anabolism" EXACT [] +synonym: "phospholipid biosynthesis" EXACT [] +synonym: "phospholipid formation" EXACT [] +synonym: "phospholipid synthesis" EXACT [] +xref: MetaCyc:LIPASYN-PWY +xref: MetaCyc:PHOSLIPSYN-PWY +xref: MetaCyc:PHOSLIPSYN2-PWY +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0008655 +name: pyrimidine-containing compound salvage +namespace: biological_process +def: "Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl] +subset: goslim_pir +synonym: "pyrimidine salvage" RELATED [] +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0008656 +name: cysteine-type endopeptidase activator activity involved in apoptotic process +namespace: molecular_function +def: "Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis] +comment: Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases. +synonym: "caspase activator activity" BROAD [] +xref: Reactome:R-HSA-205117 "p75NTR:NADE promotes caspase2/3 activation" +xref: Reactome:R-HSA-449073 "Caspase-3 cleaves pro-interleukin-16" +is_a: GO:0016505 ! peptidase activator activity involved in apoptotic process +is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process + +[Term] +id: GO:0008657 +name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] +synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0042030 ! ATPase inhibitor activity +is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity + +[Term] +id: GO:0008658 +name: penicillin binding +namespace: molecular_function +def: "Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] +subset: goslim_metagenomics +is_a: GO:0033218 ! amide binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0008659 +name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59, GOC:ai, PMID:12368867, RHEA:41892] +synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] +xref: EC:4.2.1.59 +xref: RHEA:41892 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008660 +name: 1-aminocyclopropane-1-carboxylate deaminase activity +namespace: molecular_function +alt_id: GO:0018806 +def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+)." [EC:3.5.99.7, RHEA:16933] +comment: Note that this function was formerly EC:4.1.99.4. +synonym: "1-aminocyclopropane carboxylic acid deaminase activity" RELATED [EC:3.5.99.7] +synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" RELATED [EC:3.5.99.7] +synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" RELATED [EC:3.5.99.7] +synonym: "ACC deaminase activity" RELATED [EC:3.5.99.7] +xref: EC:3.5.99.7 +xref: KEGG_REACTION:R00997 +xref: MetaCyc:4.1.99.4-RXN +xref: RHEA:16933 +xref: UM-BBD_reactionID:r0357 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008661 +name: 1-deoxy-D-xylulose-5-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)." [EC:2.2.1.7, RHEA:12605] +synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] +synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] +synonym: "DOXP synthase activity" EXACT [] +synonym: "DXP-synthase activity" EXACT [] +synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.7] +xref: EC:2.2.1.7 +xref: KEGG_REACTION:R05636 +xref: MetaCyc:DXS-RXN +xref: RHEA:12605 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0008662 +name: 1-phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] +synonym: "1-phosphofructokinase (phosphorylating)" RELATED [EC:2.7.1.56] +synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.56] +synonym: "D-fructose-1-phosphate kinase activity" RELATED [EC:2.7.1.56] +synonym: "fructose 1-phosphate kinase activity" RELATED [EC:2.7.1.56] +synonym: "fructose-1-phosphate kinase activity" RELATED [EC:2.7.1.56] +synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] +xref: EC:2.7.1.56 +xref: MetaCyc:1PFRUCTPHOSN-RXN +xref: RHEA:14213 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0008663 +name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] +synonym: "2',3 '-cyclic AMP phosphodiesterase activity" RELATED [EC:3.1.4.16] +synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" RELATED [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleotidase activity" RELATED [EC:3.1.4.16] +synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] +synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" RELATED [EC:3.1.4.16] +synonym: "2':3'-cyclic phosphodiesterase activity" RELATED [EC:3.1.4.16] +synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" RELATED [EC:3.1.4.16] +synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] +synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" RELATED [EC:3.1.4.16] +synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" RELATED [EC:3.1.4.16] +synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" RELATED [EC:3.1.4.16] +xref: EC:3.1.4.16 +xref: MetaCyc:CYCPHOSDIESTER-RXN +xref: RHEA:19621 +is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0008664 +name: 2'-5'-RNA ligase activity +namespace: molecular_function +def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112] +synonym: "2'-5' RNA ligase activity" EXACT [] +is_a: GO:0008452 ! RNA ligase activity + +[Term] +id: GO:0008666 +name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17325] +synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" RELATED [EC:2.3.1.117] +synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" RELATED [EC:2.3.1.117] +synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" RELATED [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate N-succinyltransferase activity" RELATED [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate succinylase activity" RELATED [EC:2.3.1.117] +synonym: "tetrahydrodipicolinate succinyltransferase activity" RELATED [EC:2.3.1.117] +synonym: "tetrahydropicolinate succinylase activity" RELATED [EC:2.3.1.117] +synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346] +xref: EC:2.3.1.117 +xref: KEGG_REACTION:R04365 +xref: MetaCyc:TETHYDPICSUCC-RXN +xref: RHEA:17325 +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0008667 +name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH." [EC:1.3.1.28, RHEA:23824] +synonym: "2,3-DHB dehydrogenase activity" RELATED [EC:1.3.1.28] +synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.28] +xref: EC:1.3.1.28 +xref: KEGG_REACTION:R01505 +xref: MetaCyc:DHBDEHYD-RXN +xref: RHEA:23824 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008668 +name: (2,3-dihydroxybenzoyl)adenylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate." [EC:2.7.7.58, RHEA:20229] +synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] +synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" RELATED [EC:2.7.7.58] +xref: EC:2.7.7.58 +xref: KEGG_REACTION:R01504 +xref: MetaCyc:DHBAMPLIG-RXN +xref: RHEA:20229 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0008670 +name: 2,4-dienoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] +synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase (NADPH) activity" RELATED [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase (NADPH2)" RELATED [EC:1.3.1.34] +synonym: "4-enoyl-CoA reductase activity" RELATED [EC:1.3.1.34] +synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" RELATED [EC:1.3.1.34] +xref: EC:1.3.1.34 +xref: MetaCyc:DIENOYLCOAREDUCT-RXN +xref: RHEA:12136 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008671 +name: 2-dehydro-3-deoxygalactonokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+)." [EC:2.7.1.58, RHEA:16525] +synonym: "2-keto-3-deoxy-galactonokinase activity" RELATED [EC:2.7.1.58] +synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" RELATED [EC:2.7.1.58] +synonym: "2-keto-3-deoxygalactonokinase activity" RELATED [EC:2.7.1.58] +synonym: "2-oxo-3-deoxygalactonate kinase activity" RELATED [EC:2.7.1.58] +synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" RELATED [EC:2.7.1.58] +xref: EC:2.7.1.58 +xref: KEGG_REACTION:R03387 +xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN +xref: RHEA:16525 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008672 +name: 2-dehydro-3-deoxyglucarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] +synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.20] +synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" RELATED [EC:4.1.2.20] +synonym: "2-keto-3-deoxyglucarate aldolase activity" RELATED [EC:4.1.2.20] +synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" RELATED [EC:4.1.2.20] +xref: EC:4.1.2.20 +xref: MetaCyc:KDGALDOL-RXN +xref: RHEA:10268 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008673 +name: 2-dehydro-3-deoxygluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.45, RHEA:14797] +synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" RELATED [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconate kinase activity" RELATED [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" RELATED [EC:2.7.1.45] +synonym: "2-keto-3-deoxygluconokinase activity" RELATED [EC:2.7.1.45] +synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" RELATED [EC:2.7.1.45] +synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.45] +synonym: "KDG kinase activity" RELATED [EC:2.7.1.45] +synonym: "ketodeoxygluconokinase activity" RELATED [EC:2.7.1.45] +xref: EC:2.7.1.45 +xref: KEGG_REACTION:R01541 +xref: MetaCyc:DEOXYGLUCONOKIN-RXN +xref: RHEA:14797 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008674 +name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24464] +synonym: "(KDPGal)aldolase activity" RELATED [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" RELATED [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.21] +synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" RELATED [EC:4.1.2.21] +synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" RELATED [EC:4.1.2.21] +synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" RELATED [EC:4.1.2.21] +synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21] +synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21] +synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" RELATED [EC:4.1.2.21] +synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" RELATED [EC:4.1.2.21] +xref: EC:4.1.2.21 +xref: KEGG_REACTION:R01064 +xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN +xref: RHEA:24464 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008675 +name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] +synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" RELATED [EC:4.1.2.14] +synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.14] +synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" RELATED [EC:4.1.2.14] +synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" RELATED [EC:4.1.2.14] +synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "KDPG aldolase activity" RELATED [EC:4.1.2.14] +synonym: "KDPG-aldolase activity" RELATED [EC:4.1.2.14] +synonym: "ODPG aldolase activity" RELATED [EC:4.1.2.14] +synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" RELATED [EC:4.1.2.14] +synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" RELATED [EC:4.1.2.14] +xref: EC:4.1.2.14 +xref: MetaCyc:KDPGALDOL-RXN +xref: RHEA:17089 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008676 +name: 3-deoxy-8-phosphooctulonate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate." [EC:2.5.1.55, RHEA:14053] +comment: Note that this function was formerly EC:4.1.2.16. +synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.55] +synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" RELATED [EC:2.5.1.55] +synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] +synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" RELATED [EC:2.5.1.55] +synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" RELATED [EC:2.5.1.55] +synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" RELATED [EC:2.5.1.55] +synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" RELATED [EC:2.5.1.55] +synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" RELATED [EC:2.5.1.55] +synonym: "KDO-8-P synthase activity" RELATED [EC:2.5.1.55] +synonym: "KDO-8-phosphate synthetase activity" RELATED [EC:2.5.1.55] +synonym: "KDOP synthase activity" RELATED [EC:2.5.1.55] +synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" RELATED [EC:2.5.1.55] +synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.55] +xref: EC:2.5.1.55 +xref: KEGG_REACTION:R03254 +xref: MetaCyc:KDO-8PSYNTH-RXN +xref: RHEA:14053 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008677 +name: 2-dehydropantoate 2-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [EC:1.1.1.169, RHEA:16233] +synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.169] +synonym: "2-ketopantoate reductase activity" RELATED [EC:1.1.1.169] +synonym: "2-ketopantoic acid reductase activity" RELATED [EC:1.1.1.169] +synonym: "2-oxopantoate reductase activity" RELATED [EC:1.1.1.169] +synonym: "ketopantoate reductase activity" RELATED [EC:1.1.1.169] +synonym: "ketopantoic acid reductase activity" RELATED [EC:1.1.1.169] +synonym: "KPA reductase activity" RELATED [EC:1.1.1.169] +xref: EC:1.1.1.169 +xref: KEGG_REACTION:R02472 +xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN +xref: RHEA:16233 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008678 +name: 2-deoxy-D-gluconate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] +synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.125] +synonym: "2-deoxygluconate dehydrogenase activity" RELATED [EC:1.1.1.125] +synonym: "2-keto-3-deoxygluconate oxidoreductase activity" RELATED [EC:1.1.1.125] +xref: EC:1.1.1.125 +xref: MetaCyc:KDUD-RXN +xref: RHEA:12160 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008679 +name: 2-hydroxy-3-oxopropionate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] +synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.60] +synonym: "tartronate semialdehyde reductase (NADPH) activity" RELATED [EC:1.1.1.60] +xref: EC:1.1.1.60 +xref: MetaCyc:TSA-REDUCT-RXN +xref: RHEA:18841 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008681 +name: 2-octaprenyl-6-methoxyphenol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [PMID:27822549, PMID:4572721, RHEA:29407] +xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN +xref: RHEA:29407 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008682 +name: 3-demethoxyubiquinol 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O." [RHEA:50908] +synonym: "2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity" NARROW [] +synonym: "demethoxy-ubiquinone hydroxylase" RELATED [GOC:vw] +synonym: "demethoxyubiquinone monooxygenase" RELATED [GOC:vw] +xref: EC:1.14.99.60 +xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN +xref: RHEA:50908 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0008683 +name: 2-oxoglutarate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde." [EC:4.1.1.71, RHEA:10524] +synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" RELATED [EC:4.1.1.71] +synonym: "2-oxoglutarate carboxy-lyase activity" RELATED [EC:4.1.1.71] +synonym: "alpha-ketoglutarate decarboxylase activity" RELATED [EC:4.1.1.71] +synonym: "alpha-ketoglutaric decarboxylase activity" RELATED [EC:4.1.1.71] +synonym: "pre-2-oxoglutarate decarboxylase activity" RELATED [EC:4.1.1.71] +xref: EC:4.1.1.71 +xref: KEGG_REACTION:R00272 +xref: MetaCyc:RXN-7774 +xref: RHEA:10524 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008684 +name: 2-oxopent-4-enoate hydratase activity +namespace: molecular_function +alt_id: GO:0018821 +def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] +synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" RELATED [EC:4.2.1.80] +synonym: "2-keto-4-pentenoate hydratase activity" RELATED [EC:4.2.1.80] +synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" RELATED [EC:4.2.1.80] +synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" RELATED [EC:4.2.1.80] +synonym: "OEH activity" RELATED [EC:4.2.1.80] +xref: EC:4.2.1.80 +xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN +xref: RHEA:22580 +xref: UM-BBD_enzymeID:e0078 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008685 +name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23864] +synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" RELATED [EC:4.6.1.12] +synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" RELATED [EC:4.6.1.12] +synonym: "MECDP-synthase activity" RELATED [EC:4.6.1.12] +synonym: "MECP synthase activity" EXACT [] +xref: EC:4.6.1.12 +xref: KEGG_REACTION:R05637 +xref: MetaCyc:RXN0-302 +xref: RHEA:23864 +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0008686 +name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)." [EC:4.1.99.12, RHEA:18457] +xref: EC:4.1.99.12 +xref: KEGG_REACTION:R07281 +xref: MetaCyc:DIOHBUTANONEPSYN-RXN +xref: RHEA:18457 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0008687 +name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+)." [EC:1.13.11.15, RHEA:15633] +synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.15] +synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" RELATED [EC:1.13.11.15] +synonym: "homoprotocatechuate 2,3-dioxygenase activity" RELATED [EC:1.13.11.15] +synonym: "HPC dioxygenase activity" RELATED [EC:1.13.11.15] +xref: EC:1.13.11.15 +xref: KEGG_REACTION:R03303 +xref: MetaCyc:1.13.11.15-RXN +xref: RHEA:15633 +xref: UM-BBD_reactionID:r0364 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0008688 +name: 3-(3-hydroxyphenyl)propionate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [RHEA:24785] +xref: EC:1.14.13.127 +xref: KEGG_REACTION:R06786 +xref: MetaCyc:MHPHYDROXY-RXN +xref: RHEA:24785 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008689 +name: 3-demethylubiquinone-9 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] +synonym: "5-demethylubiquinone-9 methyltransferase activity" RELATED [EC:2.1.1.64] +synonym: "OMHMB-methyltransferase activity" RELATED [EC:2.1.1.64] +synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" RELATED [EC:2.1.1.64] +synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" RELATED [EC:2.1.1.64] +xref: EC:2.1.1.64 +xref: MetaCyc:DHHB-METHYLTRANSFER-RXN +xref: RHEA:17049 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity + +[Term] +id: GO:0008690 +name: 3-deoxy-manno-octulosonate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] +synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" RELATED [EC:2.7.7.38] +synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38] +synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" RELATED [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" RELATED [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" RELATED [EC:2.7.7.38] +synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" RELATED [EC:2.7.7.38] +synonym: "CMP-KDO synthetase activity" RELATED [EC:2.7.7.38] +synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38] +synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] +synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" RELATED [EC:2.7.7.38] +synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" RELATED [EC:2.7.7.38] +xref: EC:2.7.7.38 +xref: MetaCyc:CPM-KDOSYNTH-RXN +xref: RHEA:23448 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0008691 +name: 3-hydroxybutyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] +synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.157] +synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.157] +synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157] +synonym: "BHBD activity" RELATED [EC:1.1.1.157] +synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.157] +synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157] +synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.157] +xref: EC:1.1.1.157 +xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN +xref: RHEA:16197 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008692 +name: 3-hydroxybutyryl-CoA epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] +synonym: "3-hydroxyacyl-CoA epimerase activity" RELATED [EC:5.1.2.3] +synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" RELATED [EC:5.1.2.3] +synonym: "3-hydroxybutyryl coenzyme A epimerase activity" RELATED [EC:5.1.2.3] +xref: EC:5.1.2.3 +xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN +xref: RHEA:21760 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0008693 +name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59, PMID:8910376, RHEA:41860] +synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" RELATED [EC:4.2.1.59] +synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxyacyl-ACP dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxydecanoate dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxydecanoyl thioester dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "FabA" RELATED [] +synonym: "HDDase activity" RELATED [EC:4.2.1.59] +xref: EC:4.2.1.59 +xref: RHEA:41860 +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0008694 +name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity +namespace: molecular_function +alt_id: GO:0019167 +def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] +synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] +synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] +synonym: "PPHB decarboxylase activity" EXACT [] +synonym: "UbiD" RELATED [] +synonym: "UbiX" RELATED [] +xref: EC:4.1.1.98 +xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN +xref: RHEA:27778 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008695 +name: 3-phenylpropionate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] +synonym: "3-phenylpropanoate dioxygenase activity" RELATED [EC:1.14.12.19] +synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" RELATED [EC:1.14.12.19] +synonym: "Hca dioxygenase activity" RELATED [EC:1.14.12.19] +synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] +xref: EC:1.14.12.19 +xref: MetaCyc:HCAMULTI-RXN +xref: RHEA:20357 +xref: UM-BBD_enzymeID:e0307 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0008696 +name: 4-amino-4-deoxychorismate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate." [EC:4.1.3.38, RHEA:16201] +comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. +synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" RELATED [EC:4.1.3.38] +synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" RELATED [EC:4.1.3.38] +synonym: "ADC lyase activity" RELATED [EC:4.1.3.38] +synonym: "aminodeoxychorismate lyase activity" EXACT [] +synonym: "enzyme X activity" RELATED [EC:4.1.3.38] +synonym: "p-aminobenzoate synthetase" RELATED [] +synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] +synonym: "para-aminobenzoic acid synthase" RELATED [] +xref: EC:4.1.3.38 +xref: KEGG_REACTION:R05553 +xref: MetaCyc:ADCLY-RXN +xref: RHEA:16201 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008697 +name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23896] +synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.17] +synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" RELATED [EC:5.3.1.17] +synonym: "5-keto-4-deoxyuronate isomerase activity" RELATED [EC:5.3.1.17] +xref: EC:5.3.1.17 +xref: KEGG_REACTION:R04383 +xref: MetaCyc:5.3.1.17-RXN +xref: RHEA:23896 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008700 +name: 4-hydroxy-2-oxoglutarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] +synonym: "2-keto-4-hydroxybutyrate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "2-keto-4-hydroxyglutarate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "2-keto-4-hydroxyglutaric aldolase activity" RELATED [EC:4.1.3.16] +synonym: "2-oxo-4-hydroxyglutarate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "2-oxo-4-hydroxyglutaric aldolase activity" RELATED [EC:4.1.3.16] +synonym: "4-hydroxy-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "4-hydroxy-2-ketoglutaric aldolase activity" RELATED [EC:4.1.3.16] +synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" RELATED [EC:4.1.3.16] +synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" RELATED [EC:4.1.3.16] +synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "hydroxyketoglutarate aldolase activity" RELATED [EC:4.1.3.16] +synonym: "hydroxyketoglutaric aldolase activity" RELATED [EC:4.1.3.16] +synonym: "KHG-aldolase activity" RELATED [EC:4.1.3.16] +xref: EC:4.1.3.16 +xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN +xref: Reactome:R-HSA-6784423 "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate" +xref: RHEA:18169 +is_a: GO:0016832 ! aldehyde-lyase activity +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008701 +name: 4-hydroxy-2-oxovalerate aldolase activity +namespace: molecular_function +alt_id: GO:0018804 +def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22624] +synonym: "4-hydroxy-2-ketovalerate aldolase activity" RELATED [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" RELATED [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" RELATED [EC:4.1.3.39] +synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" RELATED [EC:4.1.3.39] +synonym: "DmpG" RELATED [EC:4.1.3.39] +synonym: "HOA" RELATED [EC:4.1.3.39] +xref: EC:4.1.3.39 +xref: KEGG_REACTION:R00750 +xref: MetaCyc:MHPELY-RXN +xref: RHEA:22624 +xref: UM-BBD_enzymeID:e0077 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008703 +name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH." [EC:1.1.1.193, RHEA:17845] +synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] +synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" RELATED [EC:1.1.1.193] +synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" RELATED [EC:1.1.1.193] +xref: EC:1.1.1.193 +xref: KEGG_REACTION:R03458 +xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN +xref: RHEA:17845 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008704 +name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity +namespace: molecular_function +alt_id: GO:0018843 +def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] +synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] +synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] +synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" RELATED [EC:5.3.3.10] +synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" RELATED [EC:5.3.3.10] +synonym: "CHM isomerase activity" RELATED [EC:5.3.3.10] +synonym: "HHDD isomerase activity" EXACT [] +synonym: "hpaG-1" RELATED [] +synonym: "hpaG1" RELATED [] +xref: EC:5.3.3.10 +xref: MetaCyc:5.3.3.10-RXN +xref: RHEA:18813 +xref: UM-BBD_reactionID:r0366 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0008705 +name: methionine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11172] +synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" RELATED [EC:2.1.1.13] +synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] +synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "cobalamin-dependent methionine synthase activity" RELATED [EC:2.1.1.13] +synonym: "MetH" RELATED [EC:2.1.1.13] +synonym: "methionine synthase (cobalamin-dependent) activity" RELATED [EC:2.1.1.13] +synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" RELATED [EC:2.1.1.13] +synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" RELATED [EC:2.1.1.13] +synonym: "tetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "tetrahydropteroylglutamate methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "tetrahydropteroylglutamic methyltransferase activity" RELATED [EC:2.1.1.13] +synonym: "vitamin B12 methyltransferase activity" RELATED [EC:2.1.1.13] +xref: EC:2.1.1.13 +xref: KEGG_REACTION:R00946 +xref: MetaCyc:HOMOCYSMETB12-RXN +xref: Reactome:R-HSA-174374 "MTR transfers CH3 from MeCbl to HCYS" +xref: Reactome:R-HSA-3149539 "MTR transfers CH3 group from MTHF to cob(I)alamin" +xref: RHEA:11172 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0008706 +name: 6-phospho-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] +synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" RELATED [EC:3.2.1.86] +synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] +synonym: "phospho-beta-glucosidase activity" RELATED [EC:3.2.1.86] +synonym: "phosphocellobiase activity" RELATED [EC:3.2.1.86] +xref: EC:3.2.1.86 +xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN +xref: RHEA:10772 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0008707 +name: 4-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] +synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] +synonym: "6-phytase activity" EXACT [] +synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.26] +synonym: "phytase activity" BROAD [EC:3.1.3.26] +synonym: "phytate 6-phosphatase activity" RELATED [EC:3.1.3.26] +xref: EC:3.1.3.26 +xref: MetaCyc:6-PHYT-RXN +xref: RHEA:20960 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008709 +name: cholate 7-alpha-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.159, RHEA:19409] +synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] +synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] +synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159] +synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] +synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159] +xref: EC:1.1.1.159 +xref: KEGG_REACTION:R02792 +xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN +xref: RHEA:19409 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008710 +name: 8-amino-7-oxononanoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA." [EC:2.3.1.47, RHEA:20712] +synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" RELATED [EC:2.3.1.47] +synonym: "7-KAP synthetase activity" RELATED [EC:2.3.1.47] +synonym: "7-keto-8-amino-pelargonic acid synthetase activity" RELATED [EC:2.3.1.47] +synonym: "7-keto-8-aminopelargonic acid synthetase activity" RELATED [EC:2.3.1.47] +synonym: "7-keto-8-aminopelargonic synthetase activity" RELATED [EC:2.3.1.47] +synonym: "8-amino-7-ketopelargonate synthase activity" RELATED [EC:2.3.1.47] +synonym: "8-amino-7-oxopelargonate synthase activity" RELATED [EC:2.3.1.47] +synonym: "AONS activity" RELATED [EC:2.3.1.47] +xref: EC:2.3.1.47 +xref: KEGG_REACTION:R03210 +xref: MetaCyc:7KAPSYN-RXN +xref: RHEA:20712 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0008711 +name: obsolete ADP-L-glycero-D-manno-heptose synthase activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:curators] +comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). +synonym: "ADP-L-glycero-D-manno-heptose synthase activity" EXACT [] +is_obsolete: true +consider: GO:0033785 +consider: GO:0033786 + +[Term] +id: GO:0008712 +name: ADP-glyceromanno-heptose 6-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17577] +synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" RELATED [EC:5.1.3.20] +synonym: "ADPglyceromanno-heptose 6-epimerase activity" RELATED [EC:5.1.3.20] +xref: EC:5.1.3.20 +xref: KEGG_REACTION:R05176 +xref: MetaCyc:5.1.3.20-RXN +xref: RHEA:17577 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008713 +name: ADP-heptose-lipopolysaccharide heptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061] +synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] +xref: MetaCyc:RXN0-5061 +xref: RHEA:28538 +is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity + +[Term] +id: GO:0008714 +name: AMP nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20129] +synonym: "adenosine monophosphate nucleosidase activity" RELATED [EC:3.2.2.4] +synonym: "adenylate nucleosidase activity" RELATED [EC:3.2.2.4] +synonym: "AMP phosphoribohydrolase activity" RELATED [EC:3.2.2.4] +xref: EC:3.2.2.4 +xref: KEGG_REACTION:R00182 +xref: MetaCyc:AMP-NUCLEOSID-RXN +xref: RHEA:20129 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008715 +name: CDP-diacylglycerol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+)." [EC:3.6.1.26, RHEA:15221] +synonym: "CDP diacylglycerol hydrolase activity" RELATED [EC:3.6.1.26] +synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" RELATED [EC:3.6.1.26] +synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] +synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" RELATED [EC:3.6.1.26] +xref: EC:3.6.1.26 +xref: KEGG_REACTION:R01797 +xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN +xref: RHEA:15221 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008716 +name: D-alanine-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.4, RHEA:11224] +synonym: "alanine:alanine ligase (ADP-forming) activity" RELATED [EC:6.3.2.4] +synonym: "alanylalanine synthetase activity" RELATED [EC:6.3.2.4] +synonym: "D-Ala-D-Ala synthetase activity" RELATED [EC:6.3.2.4] +synonym: "D-alanine:D-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.4] +synonym: "D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.4] +synonym: "D-alanylalanine synthetase activity" RELATED [EC:6.3.2.4] +xref: EC:6.3.2.4 +xref: KEGG_REACTION:R01150 +xref: MetaCyc:DALADALALIG-RXN +xref: RHEA:11224 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008717 +name: obsolete D-alanyl-D-alanine endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT [] +synonym: "penicillin-binding protein 7" NARROW [] +synonym: "penicillin-binding protein 8" NARROW [] +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0008718 +name: D-amino-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [RHEA:18125] +synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [] +synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [] +xref: MetaCyc:DAADEHYDROG-RXN +xref: RHEA:18125 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0008719 +name: dihydroneopterin triphosphate 2'-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] +synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] +xref: EC:5.1.99.7 +xref: MetaCyc:H2NTPEPIM-RXN +xref: RHEA:28346 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0008720 +name: D-lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." [EC:1.1.1.28, RHEA:16369] +synonym: "D-lactic acid dehydrogenase activity" RELATED [EC:1.1.1.28] +synonym: "D-lactic dehydrogenase activity" RELATED [EC:1.1.1.28] +xref: EC:1.1.1.28 +xref: KEGG_REACTION:R00704 +xref: MetaCyc:DLACTDEHYDROGNAD-RXN +xref: RHEA:16369 +is_a: GO:0004457 ! lactate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008721 +name: D-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] +comment: Note that this function was formerly EC:4.3.1.14. +synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] +synonym: "D-hydroxyaminoacid dehydratase activity" RELATED [EC:4.3.1.18] +synonym: "D-serine ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.18] +synonym: "D-serine deaminase activity" RELATED [EC:4.3.1.18] +synonym: "D-serine dehydrase activity" RELATED [EC:4.3.1.18] +synonym: "D-serine dehydratase (deaminating) activity" RELATED [EC:4.3.1.18] +synonym: "D-serine dehydratase activity" RELATED [EC:4.3.1.18] +synonym: "D-serine dehydration activity" RELATED [] +synonym: "D-serine hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.18] +synonym: "D-serine hydrolase activity" RELATED [EC:4.3.1.18] +xref: EC:4.3.1.18 +xref: MetaCyc:DSERDEAM-RXN +xref: Reactome:R-HSA-9014741 "PXLP-K56-SRR dimer deaminates D-Ser" +xref: Reactome:R-HSA-9034539 "PXLP-K56-SRR dimer deaminates L-Ser" +xref: RHEA:13977 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008724 +name: obsolete DNA topoisomerase IV activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] +comment: This term was made obsolete because it represents a gene product. +synonym: "DNA topoisomerase IV activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003918 + +[Term] +id: GO:0008725 +name: DNA-3-methyladenine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] +synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] +synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] +synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] +synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] +synonym: "DNA-3-methyladenine glycosidase I activity" RELATED [EC:3.2.2.20] +synonym: "DNA-3-methyladenine glycosylase I activity" EXACT [] +xref: EC:3.2.2.20 +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.20-RXN +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity + +[Term] +id: GO:0008726 +name: alkanesulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280] +synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" RELATED [EC:1.14.14.5] +synonym: "alkanesulphonate monooxygenase activity" EXACT [] +synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" RELATED [EC:1.14.14.5] +synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] +synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" RELATED [EC:1.14.14.5] +synonym: "SsuD" RELATED [EC:1.14.14.5] +synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] +xref: EC:1.14.14.5 +xref: MetaCyc:RXN0-280 +xref: RHEA:23064 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0008727 +name: GDP-mannose mannosyl hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN] +xref: MetaCyc:GDPMANMANHYDRO-RXN +xref: RHEA:28102 +is_a: GO:0015923 ! mannosidase activity + +[Term] +id: GO:0008728 +name: GTP diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] +synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] +synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] +synonym: "ATP-GTP 3'-diphosphotransferase activity" RELATED [EC:2.7.6.5] +synonym: "ATP:GTP 3'-diphosphotransferase activity" RELATED [EC:2.7.6.5] +synonym: "GPSI" RELATED [EC:2.7.6.5] +synonym: "GPSII" RELATED [EC:2.7.6.5] +synonym: "GTP pyrophosphokinase activity" EXACT [] +synonym: "guanosine 3',5'-polyphosphate synthase activity" RELATED [EC:2.7.6.5] +synonym: "guanosine 5',3'-polyphosphate synthetase activity" RELATED [EC:2.7.6.5] +synonym: "guanosine pentaphosphate synthetase activity" RELATED [EC:2.7.6.5] +synonym: "ppGpp synthetase I activity" RELATED [EC:2.7.6.5] +synonym: "stringent factor activity" RELATED [EC:2.7.6.5] +xref: EC:2.7.6.5 +xref: MetaCyc:GTPPYPHOSKIN-RXN +xref: RHEA:22088 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0008730 +name: L(+)-tartrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.32, RHEA:15413] +synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" RELATED [EC:4.2.1.32] +synonym: "(R,R)-tartrate hydro-lyase activity" RELATED [EC:4.2.1.32] +synonym: "L-(+)-tartaric acid dehydratase activity" RELATED [EC:4.2.1.32] +synonym: "L-tartrate dehydratase activity" RELATED [EC:4.2.1.32] +synonym: "tartaric acid dehydrase activity" RELATED [EC:4.2.1.32] +synonym: "tartrate dehydratase activity" RELATED [EC:4.2.1.32] +xref: EC:4.2.1.32 +xref: KEGG_REACTION:R00339 +xref: MetaCyc:LTARTDEHYDRA-RXN +xref: RHEA:15413 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008732 +name: L-allo-threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [PMID:9228760, RHEA:26209] +synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] +synonym: "LtaA" RELATED [] +xref: EC:4.1.2.49 +xref: MetaCyc:LTAA-RXN +xref: RHEA:26209 +is_a: GO:0004793 ! threonine aldolase activity + +[Term] +id: GO:0008733 +name: L-arabinose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14821] +synonym: "L-arabinose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.4] +synonym: "L-arabinose ketol-isomerase activity" RELATED [EC:5.3.1.4] +xref: EC:5.3.1.4 +xref: KEGG_REACTION:R01761 +xref: MetaCyc:ARABISOM-RXN +xref: RHEA:14821 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008734 +name: L-aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.16] +synonym: "L-aspartate:oxygen oxidoreductase" RELATED [EC:1.4.3.16] +xref: EC:1.4.3.16 +xref: MetaCyc:L-ASPARTATE-OXID-RXN +xref: MetaCyc:RXN-9772 +xref: RHEA:25876 +is_a: GO:0001716 ! L-amino-acid oxidase activity +is_a: GO:0015922 ! aspartate oxidase activity + +[Term] +id: GO:0008735 +name: carnitine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O." [EC:4.2.1.89, RHEA:14577] +synonym: "L-carnitine dehydratase activity" EXACT [] +synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] +synonym: "L-carnitine hydro-lyase activity" RELATED [EC:4.2.1.89] +xref: EC:4.2.1.89 +xref: KEGG_REACTION:R01925 +xref: MetaCyc:CARNDEHYDRA-RXN +xref: RHEA:14577 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008736 +name: L-fucose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] +synonym: "L-fucose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.25] +synonym: "L-fucose ketol-isomerase activity" RELATED [EC:5.3.1.25] +xref: EC:5.3.1.25 +xref: MetaCyc:FUCISOM-RXN +xref: RHEA:17233 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008737 +name: L-fuculokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.51, RHEA:12376] +synonym: "ATP:L-fuculose 1-phosphotransferase activity" RELATED [EC:2.7.1.51] +synonym: "L-fuculokinase (phosphorylating)" RELATED [EC:2.7.1.51] +synonym: "L-fuculose kinase activity" RELATED [EC:2.7.1.51] +xref: EC:2.7.1.51 +xref: KEGG_REACTION:R03241 +xref: MetaCyc:FUCULOKIN-RXN +xref: RHEA:12376 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008738 +name: L-fuculose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12933] +synonym: "fuculose aldolase activity" RELATED [EC:4.1.2.17] +synonym: "L-fuculose 1-phosphate aldolase activity" RELATED [EC:4.1.2.17] +synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" RELATED [EC:4.1.2.17] +synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.17] +xref: EC:4.1.2.17 +xref: KEGG_REACTION:R02262 +xref: MetaCyc:FUCPALDOL-RXN +xref: RHEA:12933 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008740 +name: L-rhamnose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14, RHEA:23160] +synonym: "L-rhamnose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.14] +synonym: "L-rhamnose ketol-isomerase activity" RELATED [EC:5.3.1.14] +synonym: "rhamnose isomerase activity" RELATED [EC:5.3.1.14] +xref: EC:5.3.1.14 +xref: KEGG_REACTION:R02437 +xref: MetaCyc:RHAMNISOM-RXN +xref: RHEA:23160 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008741 +name: ribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] +synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" RELATED [EC:2.7.1.16] +synonym: "L-ribulokinase activity" EXACT [] +synonym: "ribulokinase (phosphorylating)" RELATED [EC:2.7.1.16] +xref: EC:2.7.1.16 +xref: MetaCyc:RIBULOKIN-RXN +xref: RHEA:22072 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008742 +name: L-ribulose-phosphate 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22368] +synonym: "AraD" RELATED [EC:5.1.3.4] +synonym: "L-ribulose 5-phosphate 4-epimerase activity" RELATED [EC:5.1.3.4] +synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] +synonym: "L-Ru5P" RELATED [EC:5.1.3.4] +synonym: "L-ru5P activity" RELATED [EC:5.1.3.4] +synonym: "phosphoribulose isomerase activity" RELATED [EC:5.1.3.4] +synonym: "ribulose phosphate 4-epimerase activity" RELATED [EC:5.1.3.4] +xref: EC:5.1.3.4 +xref: KEGG_REACTION:R05850 +xref: MetaCyc:RIBULPEPIM-RXN +xref: RHEA:22368 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008743 +name: L-threonine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + CO(2) + NADH." [EC:1.1.1.103, RHEA:13161] +synonym: "L-threonine dehydrogenase activity" RELATED [EC:1.1.1.103] +synonym: "L-threonine:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.103] +synonym: "threonine 3-dehydrogenase activity" BROAD [] +synonym: "threonine dehydrogenase activity" RELATED [EC:1.1.1.103] +xref: EC:1.1.1.103 +xref: KEGG_REACTION:R01465 +xref: MetaCyc:THREODEHYD-RXN +xref: Reactome:R-HSA-6798667 "TDH tetramer oxidises L-Thr to 2A-3OB" +xref: RHEA:13161 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008744 +name: L-xylulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] +synonym: "ATP:L-xylulose 5-phosphotransferase activity" RELATED [EC:2.7.1.53] +synonym: "L-xylulokinase (phosphorylating)" RELATED [EC:2.7.1.53] +synonym: "L-xylulose kinase activity" RELATED [EC:2.7.1.53] +xref: EC:2.7.1.53 +xref: MetaCyc:LYXK-RXN +xref: RHEA:18869 +is_a: GO:0004856 ! xylulokinase activity + +[Term] +id: GO:0008745 +name: N-acetylmuramoyl-L-alanine amidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28, PMID:22748813] +synonym: "acetylmuramoyl-alanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "acetylmuramyl-alanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "acetylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramic acid L-alanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "N-acetylmuramylalanine amidase activity" RELATED [EC:3.5.1.28] +synonym: "N-acylmuramyl-L-alanine amidase activity" RELATED [EC:3.5.1.28] +xref: EC:3.5.1.28 +xref: MetaCyc:3.5.1.28-RXN +xref: Reactome:R-HSA-6799977 "PGLYRP2 hydrolyzes bacterial peptidoglycan" +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0061783 ! peptidoglycan muralytic activity + +[Term] +id: GO:0008746 +name: NAD(P)+ transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] +synonym: "energy-linked transhydrogenase" RELATED [EC:1.6.1.1, EC:1.6.1.2] +synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] +xref: EC:1.6.1.1 +xref: KEGG_REACTION:R00112 +xref: Reactome:R-HSA-450971 "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]" +xref: RHEA:11692 +is_a: GO:0016652 ! oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor + +[Term] +id: GO:0008747 +name: N-acetylneuraminate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23296] +synonym: "acetylneuraminate lyase activity" RELATED [EC:4.1.3.3] +synonym: "acetylneuraminate pyruvate-lyase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminate aldolase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminate pyruvate-lyase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminic acid aldolase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminic acid lyase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminic aldolase activity" RELATED [EC:4.1.3.3] +synonym: "N-acetylneuraminic lyase activity" RELATED [EC:4.1.3.3] +synonym: "NALase activity" RELATED [EC:4.1.3.3] +synonym: "NANA lyase activity" RELATED [EC:4.1.3.3] +synonym: "neuraminate aldolase activity" RELATED [EC:4.1.3.3] +synonym: "neuraminic acid aldolase activity" RELATED [EC:4.1.3.3] +synonym: "neuraminic aldolase activity" RELATED [EC:4.1.3.3] +synonym: "NPL" RELATED [EC:4.1.3.3] +synonym: "sialate lyase activity" RELATED [EC:4.1.3.3] +synonym: "sialic acid aldolase activity" RELATED [EC:4.1.3.3] +synonym: "sialic aldolase activity" RELATED [EC:4.1.3.3] +xref: EC:4.1.3.3 +xref: KEGG_REACTION:R01811 +xref: MetaCyc:ACNEULY-RXN +xref: Reactome:R-HSA-4085217 "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate" +xref: RHEA:23296 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008748 +name: N-ethylmaleimide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101] +xref: MetaCyc:RXN0-5101 +xref: RHEA:35523 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008750 +name: NAD(P)+ transhydrogenase (AB-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf] +synonym: "NAD(P) transhydrogenase (AB-specific) activity" RELATED [EC:1.6.1.2] +synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" RELATED [EC:1.6.1.2] +synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] +synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] +xref: EC:1.6.1.2 +xref: MetaCyc:1.6.1.2-RXN +is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity + +[Term] +id: GO:0008751 +name: obsolete NAD(P)H dehydrogenase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it is a redundant grouping term with only one child. +synonym: "NAD(P)H dehydrogenase" EXACT [] +is_obsolete: true +consider: GO:0016651 + +[Term] +id: GO:0008752 +name: FMN reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.39] +synonym: "flavin mononucleotide reductase activity" RELATED [] +synonym: "flavine mononucleotide reductase activity" RELATED [EC:1.5.1.29] +synonym: "FMNH2:NAD(P)+ oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] +synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H(2):FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H-dependent FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H-FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H2 dehydrogenase (FMN)" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H2:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H:flavin oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NAD(P)H:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" RELATED [EC:1.5.1.29] +synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "SsuE" RELATED [EC:1.5.1.29] +xref: EC:1.5.1.39 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008753 +name: NADPH dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol." [EC:1.6.5.10] +synonym: "NADPH oxidase" BROAD [EC:1.6.5.10] +synonym: "NADPH:(quinone-acceptor) oxidoreductase" RELATED [EC:1.6.5.10] +synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" RELATED [EC:1.6.5.10] +xref: EC:1.6.5.10 +xref: KEGG_REACTION:R07359 +xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN +xref: RHEA:46164 +is_a: GO:0003955 ! NAD(P)H dehydrogenase (quinone) activity + +[Term] +id: GO:0008754 +name: O antigen ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294] +xref: MetaCyc:RXN0-5294 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0008755 +name: O antigen polymerase activity +namespace: molecular_function +def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108] +synonym: "O-antigen polymerase activity" EXACT [] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008756 +name: o-succinylbenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] +synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.26] +synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.26] +synonym: "o-succinylbenzoyl-CoA synthetase activity" RELATED [EC:6.2.1.26] +synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.26] +synonym: "OSB-CoA synthetase activity" RELATED [EC:6.2.1.26] +xref: EC:6.2.1.26 +xref: KEGG_REACTION:R04030 +xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN +xref: RHEA:17009 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0008757 +name: S-adenosylmethionine-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] +synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] +synonym: "SAM-dependent methyltransferase activity" EXACT [] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0008758 +name: UDP-2,3-diacylglucosamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] +xref: MetaCyc:LIPIDXSYNTHESIS-RXN +xref: RHEA:25213 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008759 +name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] +xref: EC:3.5.1.108 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008760 +name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18681] +synonym: "enoylpyruvate transferase activity" RELATED [EC:2.5.1.7] +synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] +synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" RELATED [EC:2.5.1.7] +synonym: "pyruvate-UDP-acetylglucosamine transferase activity" RELATED [EC:2.5.1.7] +synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" RELATED [EC:2.5.1.7] +synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" RELATED [EC:2.5.1.7] +synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" RELATED [EC:2.5.1.7] +synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" RELATED [EC:2.5.1.7] +synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" RELATED [EC:2.5.1.7] +xref: EC:2.5.1.7 +xref: KEGG_REACTION:R00660 +xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN +xref: RHEA:18681 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008761 +name: UDP-N-acetylglucosamine 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] +synonym: "UDP-GlcNAc-2-epimerase activity" RELATED [EC:5.1.3.14] +synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.14] +synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14] +synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" RELATED [EC:5.1.3.14] +synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14] +synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" RELATED [EC:5.1.3.14] +xref: EC:5.1.3.14 +xref: MetaCyc:UDPGLCNACEPIM-RXN +xref: Reactome:R-HSA-4085021 "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP" +xref: Reactome:R-HSA-4088338 "Defective GNE does not hydrolyse UDP-GlcNAc" +xref: RHEA:17213 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008762 +name: UDP-N-acetylmuramate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.3.1.98] +synonym: "MurB reductase" RELATED [EC:1.3.1.98] +synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" RELATED [EC:1.3.1.98] +synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" RELATED [EC:1.3.1.98] +synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" RELATED [EC:1.3.1.98] +synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.98] +synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" RELATED [EC:1.3.1.98] +synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" RELATED [EC:1.3.1.98] +synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" RELATED [EC:1.3.1.98] +xref: EC:1.3.1.98 +xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN +xref: RHEA:12248 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008763 +name: UDP-N-acetylmuramate-L-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23372] +synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] +synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] +synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] +synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] +synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "UDP-MurNAc:L-alanine ligase activity" RELATED [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramoylalanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" RELATED [EC:6.3.2.8] +synonym: "UDPMurNAc-L-alanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" RELATED [EC:6.3.2.8] +synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" RELATED [EC:6.3.2.8] +synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" RELATED [EC:6.3.2.8] +xref: EC:6.3.2.8 +xref: KEGG_REACTION:R03193 +xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN +xref: RHEA:23372 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008764 +name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9, RHEA:16429] +synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] +synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] +synonym: "MurD synthetase activity" RELATED [EC:6.3.2.9] +synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" RELATED [EC:6.3.2.9] +synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" RELATED [EC:6.3.2.9] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" RELATED [EC:6.3.2.9] +synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" RELATED [EC:6.3.2.9] +xref: EC:6.3.2.9 +xref: KEGG_REACTION:R02783 +xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN +xref: RHEA:16429 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008765 +name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23676] +synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" RELATED [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" RELATED [EC:6.3.2.13] +synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" RELATED [EC:6.3.2.13] +xref: EC:6.3.2.13 +xref: KEGG_REACTION:R02788 +xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN +xref: RHEA:23676 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008766 +name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [RHEA:28374] +comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). +xref: EC:6.3.2.10 +xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN +xref: RHEA:28374 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008767 +name: UDP-galactopyranose mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] +synonym: "UDP-D-galactopyranose furanomutase activity" RELATED [EC:5.4.99.9] +synonym: "UDPgalactopyranose mutase activity" RELATED [EC:5.4.99.9] +xref: EC:5.4.99.9 +xref: MetaCyc:GALPMUT-RXN +xref: RHEA:24132 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0008768 +name: UDP-sugar diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] +synonym: "nucleosidediphosphate-sugar diphosphatase activity" RELATED [EC:3.6.1.45] +synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" RELATED [EC:3.6.1.45] +synonym: "UDP-sugar hydrolase activity" RELATED [EC:3.6.1.45] +synonym: "UDP-sugar pyrophosphatase activity" RELATED [EC:3.6.1.45] +synonym: "UDP-sugar sugarphosphohydrolase activity" RELATED [EC:3.6.1.45] +xref: EC:3.6.1.45 +xref: MetaCyc:UDPSUGARHYDRO-RXN +xref: Reactome:R-HSA-6810464 "NUDT14 hydrolyses UDP-Glc to G1P and UMP" +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008769 +name: obsolete X-His dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoacyl-histidine dipeptidase activity" RELATED [EC:3.4.13.3] +synonym: "aminoacylhistidine dipeptidase activity" RELATED [EC:3.4.13.3] +synonym: "carnosinase activity" RELATED [EC:3.4.13.3] +synonym: "dipeptidase M" RELATED [EC:3.4.13.3] +synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] +synonym: "X-His dipeptidase activity" EXACT [] +synonym: "Xaa-His dipeptidase activity" EXACT [] +xref: EC:3.4.13.3 +xref: MetaCyc:3.4.13.3-RXN +is_obsolete: true +consider: GO:0008235 +consider: GO:0016805 + +[Term] +id: GO:0008770 +name: [acyl-carrier-protein] phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] +synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] +synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14] +synonym: "ACP hydrolyase activity" RELATED [EC:3.1.4.14] +synonym: "ACP phosphodiesterase activity" EXACT [] +synonym: "AcpH" RELATED [EC:3.1.4.14] +synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14] +synonym: "acyl-carrier-protein phosphodiesterase activity" RELATED [EC:3.1.4.14] +synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" RELATED [EC:3.1.4.14] +xref: EC:3.1.4.14 +xref: MetaCyc:3.1.4.14-RXN +xref: RHEA:20537 +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008771 +name: [citrate (pro-3S)-lyase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] +synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" RELATED [EC:6.2.1.22] +synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] +synonym: "acetate:HS-citrate lyase ligase activity" RELATED [EC:6.2.1.22] +synonym: "citrate (pro-3S)-lyase ligase activity" RELATED [EC:6.2.1.22] +synonym: "citrate lyase ligase activity" RELATED [EC:6.2.1.22] +synonym: "citrate lyase synthetase activity" RELATED [EC:6.2.1.22] +xref: EC:6.2.1.22 +xref: KEGG_REACTION:R04449 +xref: MetaCyc:CITC-RXN +xref: RHEA:23788 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0008772 +name: [isocitrate dehydrogenase (NADP+)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] +synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" RELATED [EC:2.7.11.5] +synonym: "ICDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] +synonym: "IDH kinase activity" RELATED [EC:2.7.11.5] +synonym: "IDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] +synonym: "IDH-K/P" RELATED [EC:2.7.11.5] +synonym: "IDHK/P" BROAD [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase (NADP) kinase activity" RELATED [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase (NADP+) kinase activity" RELATED [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase activity" RELATED [EC:2.7.11.5] +synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] +xref: EC:2.7.11.5 +xref: MetaCyc:PHOSICITDEHASE-RXN +xref: RHEA:43540 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0008773 +name: [protein-PII] uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] +synonym: "PII uridylyl-transferase activity" RELATED [EC:2.7.7.59] +synonym: "protein-PII uridylyltransferase activity" RELATED [EC:2.7.7.59] +synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] +synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] +synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] +synonym: "UTP:protein-PII uridylyltransferase activity" RELATED [EC:2.7.7.59] +xref: EC:2.7.7.59 +xref: MetaCyc:URITRANS-RXN +xref: RHEA:13673 +is_a: GO:0070569 ! uridylyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008774 +name: acetaldehyde dehydrogenase (acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] +synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.1.10] +synonym: "acylating acetaldehyde dehydrogenase activity" RELATED [EC:1.2.1.10] +synonym: "ADA" RELATED [EC:1.2.1.10] +synonym: "aldehyde dehydrogenase (acylating) activity" RELATED [EC:1.2.1.10] +synonym: "DmpF" RELATED [EC:1.2.1.10] +xref: EC:1.2.1.10 +xref: MetaCyc:ACETALD-DEHYDROG-RXN +xref: RHEA:23288 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008775 +name: acetate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] +synonym: "acetate coenzyme A-transferase activity" RELATED [EC:2.8.3.8] +synonym: "acetyl-CoA:acetoacetate CoA transferase activity" RELATED [EC:2.8.3.8] +synonym: "acyl-CoA:acetate CoA-transferase activity" RELATED [EC:2.8.3.8] +synonym: "butyryl CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.8] +synonym: "butyryl coenzyme A transferase activity" RELATED [EC:2.8.3.8] +synonym: "succinyl-CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.8] +xref: EC:2.8.3.8 +xref: MetaCyc:ACECOATRANS-RXN +xref: Reactome:R-HSA-2066788 "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase" +xref: RHEA:13381 +xref: UM-BBD_enzymeID:e0012 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008776 +name: acetate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] +synonym: "acetate kinase (phosphorylating) activity" RELATED [EC:2.7.2.1] +synonym: "acetic kinase activity" RELATED [EC:2.7.2.1] +synonym: "acetokinase activity" RELATED [EC:2.7.2.1] +synonym: "AckA" RELATED [EC:2.7.2.1] +synonym: "AK activity" RELATED [EC:2.7.2.1] +synonym: "ATP:acetate phosphotransferase activity" RELATED [EC:2.7.2.1] +xref: EC:2.7.2.1 +xref: MetaCyc:ACETATEKIN-RXN +xref: RHEA:11352 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008777 +name: acetylornithine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] +synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" RELATED [EC:3.5.1.16] +synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] +synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] +synonym: "N2-acetyl-L-ornithine amidohydrolase activity" RELATED [EC:3.5.1.16] +xref: EC:3.5.1.16 +xref: MetaCyc:ACETYLORNDEACET-RXN +xref: RHEA:15941 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0008779 +name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] +synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] +synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" RELATED [EC:2.3.1.40] +synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" RELATED [EC:2.3.1.40] +xref: EC:2.3.1.40 +xref: MetaCyc:ACYLGPEACYLTRANS-RXN +xref: RHEA:10304 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0008780 +name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] +synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" RELATED [EC:2.3.1.129] +synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] +synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] +synonym: "UDP-N-acetylglucosamine acyltransferase activity" RELATED [EC:2.3.1.129] +synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" RELATED [EC:2.3.1.129] +xref: EC:2.3.1.129 +xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN +xref: RHEA:13925 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0008781 +name: N-acylneuraminate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] +synonym: "acetylneuraminate cytidylyltransferase activity" RELATED [EC:2.7.7.43] +synonym: "acylneuraminate cytidyltransferase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminate synthase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminate synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminic acid synthase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-NANA synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-Neu5Ac synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-NeuAc synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-NeuNAc synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialate diphosphorylase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialate pyrophosphorylase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialate synthase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialate synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialic acid synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CMP-sialic synthetase activity" RELATED [EC:2.7.7.43] +synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] +synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine 5'-monophosphosialic acid synthetase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine monophosphoacetylneuraminic synthetase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine monophosphosialate pyrophosphorylase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine monophosphosialate synthetase activity" RELATED [EC:2.7.7.43] +synonym: "cytidine monophosphosialic acid synthetase activity" RELATED [EC:2.7.7.43] +xref: EC:2.7.7.43 +xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN +xref: Reactome:R-HSA-4084982 "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac" +xref: RHEA:11344 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0008782 +name: adenosylhomocysteine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] +synonym: "5'-methyladenosine nucleosidase activity" RELATED [EC:3.2.2.9] +synonym: "AdoHcy/MTA nucleosidase activity" RELATED [EC:3.2.2.9] +synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" RELATED [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine nucleosidase activity" RELATED [EC:3.2.2.9] +synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" RELATED [EC:3.2.2.9] +xref: EC:3.2.2.9 +xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN +xref: RHEA:17805 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0008783 +name: agmatinase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea." [EC:3.5.3.11, RHEA:13929] +synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] +synonym: "agmatine ureohydrolase activity" RELATED [EC:3.5.3.11] +synonym: "SpeB" RELATED [EC:3.5.3.11] +xref: EC:3.5.3.11 +xref: KEGG_REACTION:R01157 +xref: MetaCyc:AGMATIN-RXN +xref: Reactome:R-HSA-350604 "Agmatine + H2O <=> putrescine + urea" +xref: RHEA:13929 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0008784 +name: alanine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20249] +synonym: "L-alanine racemase activity" RELATED [EC:5.1.1.1] +xref: EC:5.1.1.1 +xref: KEGG_REACTION:R00401 +xref: MetaCyc:ALARACECAT-RXN +xref: RHEA:20249 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0008785 +name: alkyl hydroperoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_reactionID:r0684] +xref: Reactome:R-HSA-1222526 "AhpC reduces peroxidated lipids" +xref: UM-BBD_reactionID:r0684 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0008786 +name: allose 6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] +xref: MetaCyc:RXN0-303 +xref: RHEA:28430 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008787 +name: allose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] +synonym: "allokinase (phosphorylating)" RELATED [EC:2.7.1.55] +synonym: "allokinase activity" RELATED [EC:2.7.1.55] +synonym: "ATP:D-allose 6-phosphotransferase activity" RELATED [EC:2.7.1.55] +synonym: "D-allokinase activity" RELATED [EC:2.7.1.55] +synonym: "D-allose-6-kinase activity" RELATED [EC:2.7.1.55] +xref: EC:2.7.1.55 +xref: MetaCyc:ALLOSE-KINASE-RXN +xref: RHEA:14805 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008788 +name: alpha,alpha-phosphotrehalase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] +synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" RELATED [EC:3.2.1.93] +synonym: "phosphotrehalase activity" RELATED [EC:3.2.1.93] +synonym: "trehalose-6-phosphate hydrolase activity" RELATED [EC:3.2.1.93] +xref: EC:3.2.1.93 +xref: MetaCyc:TRE6PHYDRO-RXN +xref: RHEA:23008 +is_a: GO:0015927 ! trehalase activity + +[Term] +id: GO:0008789 +name: altronate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.7, RHEA:15957] +synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" RELATED [EC:4.2.1.7] +synonym: "D-altronate hydro-lyase activity" RELATED [EC:4.2.1.7] +xref: EC:4.2.1.7 +xref: KEGG_REACTION:R01540 +xref: MetaCyc:ALTRODEHYDRAT-RXN +xref: RHEA:15957 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008790 +name: arabinose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] +synonym: "D-arabinose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.3] +synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] +synonym: "D-arabinose ketol-isomerase activity" RELATED [EC:5.3.1.3] +synonym: "D-arabinose(L-fucose) isomerase activity" RELATED [EC:5.3.1.3] +xref: EC:5.3.1.3 +xref: MetaCyc:DARABISOM-RXN +xref: RHEA:13849 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008791 +name: arginine N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] +synonym: "AOST activity" RELATED [EC:2.3.1.109] +synonym: "arginine and ornithine N(2)-succinyltransferase activity" RELATED [EC:2.3.1.109] +synonym: "arginine and ornithine N2-succinyltransferase activity" RELATED [EC:2.3.1.109] +synonym: "arginine succinyltransferase activity" RELATED [EC:2.3.1.109] +synonym: "AST activity" RELATED [EC:2.3.1.109] +synonym: "AstA" RELATED [EC:2.3.1.109] +synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" RELATED [EC:2.3.1.109] +synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" RELATED [EC:2.3.1.109] +xref: EC:2.3.1.109 +xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN +xref: RHEA:15185 +is_a: GO:0016749 ! N-succinyltransferase activity + +[Term] +id: GO:0008792 +name: arginine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2)." [EC:4.1.1.19, RHEA:17641] +synonym: "L-arginine carboxy-lyase (agmatine-forming)" RELATED [EC:4.1.1.19] +synonym: "L-arginine carboxy-lyase activity" RELATED [EC:4.1.1.19] +synonym: "SpeA" RELATED [EC:4.1.1.19] +xref: EC:4.1.1.19 +xref: KEGG_REACTION:R00566 +xref: MetaCyc:ARGDECARBOX-RXN +xref: Reactome:R-HSA-350598 "Arginine<=>Agmatine+CO2" +xref: RHEA:17641 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008793 +name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] +synonym: "ArAT" RELATED [EC:2.6.1.57] +synonym: "aromatic amino acid aminotransferase activity" RELATED [EC:2.6.1.57] +synonym: "aromatic amino acid transferase activity" EXACT [] +synonym: "aromatic aminotransferase activity" EXACT [] +synonym: "aromatic-amino-acid transaminase activity" RELATED [EC:2.6.1.57] +xref: EC:2.6.1.57 +xref: MetaCyc:2.6.1.57-RXN +xref: RHEA:17533 +xref: UM-BBD_reactionID:r0297 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0008794 +name: arsenate reductase (glutaredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] +synonym: "glutharedoxin:arsenate oxidoreductase activity" RELATED [EC:1.20.4.1] +xref: EC:1.20.4.1 +xref: MetaCyc:RXN-982 +xref: RHEA:22016 +xref: UM-BBD_reactionID:r0635 +is_a: GO:0030611 ! arsenate reductase activity +is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor + +[Term] +id: GO:0008795 +name: NAD+ synthase activity +namespace: molecular_function +alt_id: GO:0008749 +alt_id: GO:0016965 +def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] +synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.5] +synonym: "diphosphopyridine nucleotide synthetase activity" RELATED [EC:6.3.1.5] +synonym: "NAD synthase (AMP-forming)" EXACT [] +synonym: "NAD synthase activity" EXACT [] +synonym: "NAD synthetase activity" RELATED [EC:6.3.1.5] +synonym: "NAD(+) synthetase activity" RELATED [EC:6.3.1.5] +synonym: "NAD+ synthetase activity" RELATED [EC:6.3.1.5] +synonym: "nicotinamide adenine dinucleotide synthetase activity" RELATED [EC:6.3.1.5] +xref: EC:6.3.1.5 +xref: MetaCyc:NAD-SYNTH-NH3-RXN +xref: RHEA:21188 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0008796 +name: bis(5'-nucleosyl)-tetraphosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0008797 +name: aspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] +synonym: "aspartase activity" RELATED [EC:4.3.1.1] +synonym: "fumaric aminase activity" RELATED [EC:4.3.1.1] +synonym: "L-aspartase activity" RELATED [EC:4.3.1.1] +synonym: "L-aspartate ammonia-lyase (fumarate-forming)" RELATED [EC:4.3.1.1] +synonym: "L-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.1] +xref: EC:4.3.1.1 +xref: MetaCyc:ASPARTASE-RXN +xref: RHEA:16601 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008798 +name: beta-aspartyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] +synonym: "beta-aspartyl dipeptidase activity" RELATED [EC:3.4.19.5] +synonym: "beta-aspartyl peptidase activity" RELATED [EC:3.4.19.5] +xref: EC:3.4.19.5 +xref: MetaCyc:3.4.19.5-RXN +xref: Reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)" +xref: Reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe" +is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity + +[Term] +id: GO:0008800 +name: beta-lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] +synonym: "ampicillinase activity" RELATED [EC:3.5.2.6] +synonym: "beta-lactam hydrolase activity" RELATED [EC:3.5.2.6] +synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] +synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] +synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] +synonym: "cephalosporin-beta-lactamase activity" RELATED [EC:3.5.2.6] +synonym: "exopenicillinase activity" RELATED [EC:3.5.2.6] +synonym: "neutrapen" RELATED [EC:3.5.2.6] +synonym: "penicillin amido-beta-lactamhydrolase activity" RELATED [EC:3.5.2.6] +synonym: "penicillin beta-lactamase activity" RELATED [EC:3.5.2.6] +synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] +xref: EC:3.5.2.6 +xref: MetaCyc:BETA-LACTAMASE-RXN +xref: RHEA:20401 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0008801 +name: beta-phosphoglucomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20113] +synonym: "beta-D-glucose 1,6-phosphomutase activity" RELATED [EC:5.4.2.6] +xref: EC:5.4.2.6 +xref: KEGG_REACTION:R02728 +xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN +xref: RHEA:20113 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008802 +name: betaine-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] +synonym: "BADH activity" RELATED [EC:1.2.1.8] +synonym: "betaine aldehyde dehydrogenase activity" RELATED [EC:1.2.1.8] +synonym: "betaine aldehyde oxidase activity" RELATED [EC:1.2.1.8] +synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.8] +synonym: "BetB" RELATED [EC:1.2.1.8] +xref: EC:1.2.1.8 +xref: MetaCyc:BADH-RXN +xref: Reactome:R-HSA-6797955 "ALDH7A1 oxidises BETALD to BET" +xref: RHEA:15305 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0008803 +name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity +namespace: molecular_function +def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+)." [EC:3.6.1.41, RHEA:24252] +synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" RELATED [EC:3.6.1.41] +synonym: "adenosine tetraphosphate phosphodiesterase activity" RELATED [EC:3.6.1.41] +synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] +synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] +synonym: "bis(5'-adenosyl) tetraphosphatase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosine polyphosphate hydrolase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] +synonym: "diadenosine tetraphosphate hydrolase activity" RELATED [EC:3.6.1.41] +synonym: "diadenosinetetraphosphatase (symmetrical) activity" RELATED [EC:3.6.1.41] +synonym: "dinucleosidetetraphosphatase (symmetrical) activity" RELATED [EC:3.6.1.41] +synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] +synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" RELATED [EC:3.6.1.41] +synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" RELATED [EC:3.6.1.41] +xref: EC:3.6.1.41 +xref: KEGG_REACTION:R00125 +xref: MetaCyc:3.6.1.41-RXN +xref: RHEA:24252 +is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity + +[Term] +id: GO:0008804 +name: carbamate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] +synonym: "ATP:carbamate phosphotransferase activity" RELATED [EC:2.7.2.2] +synonym: "carbamoyl phosphokinase activity" RELATED [EC:2.7.2.2] +synonym: "carbamyl phosphokinase activity" RELATED [EC:2.7.2.2] +synonym: "CKase activity" RELATED [EC:2.7.2.2] +xref: EC:2.7.2.2 +xref: MetaCyc:CARBAMATE-KINASE-RXN +xref: RHEA:10152 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008805 +name: carbon-monoxide oxygenase activity +namespace: molecular_function +alt_id: GO:0018999 +alt_id: GO:0047767 +def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [GOC:curators, RHEA:48880] +synonym: "carbon monoxide oxidase activity" RELATED [] +synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [] +synonym: "carbon monoxide oxygenase activity" EXACT [] +synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" RELATED [] +synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [] +synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" RELATED [] +synonym: "cytochrome b561" NARROW [] +xref: EC:1.2.5.3 +xref: MetaCyc:RXN-21452 +xref: RHEA:48880 +xref: UM-BBD_reactionID:r0650 +xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0008806 +name: carboxymethylenebutenolidase activity +namespace: molecular_function +alt_id: GO:0018735 +def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] +synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" RELATED [EC:3.1.1.45] +synonym: "carboxymethylene butenolide hydrolase activity" RELATED [EC:3.1.1.45] +synonym: "dienelactone hydrolase activity" RELATED [EC:3.1.1.45] +synonym: "maleylacetate enol-lactonase activity" RELATED [EC:3.1.1.45] +xref: EC:3.1.1.45 +xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN +xref: RHEA:12372 +xref: UM-BBD_enzymeID:e0066 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0008807 +name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] +synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" RELATED [EC:2.7.8.23] +synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" RELATED [EC:2.7.8.23] +synonym: "CPEP phosphonomutase activity" RELATED [EC:2.7.8.23] +xref: EC:2.7.8.23 +xref: MetaCyc:2.7.8.23-RXN +xref: RHEA:14045 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008808 +name: cardiolipin synthase activity +namespace: molecular_function +alt_id: GO:0043788 +def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl, RHEA:31451] +synonym: "cardiolipin synthase 2 activity" RELATED [] +synonym: "cardiolipin synthetase 2 activity" RELATED [] +synonym: "cardiolipin synthetase activity" BROAD [] +synonym: "diphosphatidylglycerol synthase activity" EXACT [] +xref: MetaCyc:CARDIOLIPSYN-RXN +xref: RHEA:31451 +is_a: GO:0030572 ! phosphatidyltransferase activity + +[Term] +id: GO:0008809 +name: carnitine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] +xref: MetaCyc:CARNRACE-RXN +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0008810 +name: cellulase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] +synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.4] +synonym: "9.5 cellulase activity" RELATED [EC:3.2.1.4] +synonym: "alkali cellulase activity" NARROW [EC:3.2.1.4] +synonym: "avicelase activity" RELATED [EC:3.2.1.4] +synonym: "beta-1,4-endoglucan hydrolase activity" BROAD [EC:3.2.1.4] +synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] +synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] +synonym: "celluase A" RELATED [EC:3.2.1.4] +synonym: "celludextrinase activity" RELATED [EC:3.2.1.4] +synonym: "cellulase A 3" RELATED [EC:3.2.1.4] +synonym: "cellulosin AP" RELATED [EC:3.2.1.4] +synonym: "endo-1,4-beta-D-glucanase activity" BROAD [EC:3.2.1.4] +synonym: "endo-1,4-beta-D-glucanohydrolase activity" BROAD [EC:3.2.1.4] +synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.4] +synonym: "endoglucanase activity" BROAD [EC:3.2.1.4] +synonym: "endoglucanase D" RELATED [EC:3.2.1.4] +synonym: "pancellase SS" RELATED [EC:3.2.1.4] +xref: EC:3.2.1.4 +xref: MetaCyc:RXN-2043 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0008811 +name: chloramphenicol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18421] +synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" RELATED [EC:2.3.1.28] +synonym: "CAT I" RELATED [EC:2.3.1.28] +synonym: "CAT II" RELATED [EC:2.3.1.28] +synonym: "CAT III" RELATED [EC:2.3.1.28] +synonym: "chloramphenicol acetylase activity" RELATED [EC:2.3.1.28] +synonym: "chloramphenicol acetyltransferase activity" RELATED [EC:2.3.1.28] +synonym: "chloramphenicol transacetylase activity" RELATED [EC:2.3.1.28] +xref: EC:2.3.1.28 +xref: KEGG_REACTION:R03065 +xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN +xref: RHEA:18421 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008812 +name: choline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17433] +synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] +synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] +synonym: "choline:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.1] +synonym: "choline:(acceptor) oxidoreductase activity" RELATED [EC:1.1.99.1] +synonym: "choline:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.1] +xref: EC:1.1.99.1 +xref: KEGG_REACTION:R01025 +xref: MetaCyc:CHD-RXN +xref: Reactome:R-HSA-6797961 "CHDH oxidises Cho to BETALD" +xref: RHEA:17433 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0008813 +name: chorismate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16505] +synonym: "4-hydroxybenzoate synthetase activity" EXACT [] +synonym: "chorismate pyruvate lyase activity" EXACT [] +synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" RELATED [EC:4.1.3.40] +synonym: "CL" RELATED [EC:4.1.3.40] +synonym: "CPL" RELATED [EC:4.1.3.40] +synonym: "UbiC" RELATED [EC:4.1.3.40] +xref: EC:4.1.3.40 +xref: KEGG_REACTION:R01302 +xref: MetaCyc:CHORPYRLY-RXN +xref: RHEA:16505 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008814 +name: citrate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] +synonym: "acetyl-CoA:citrate CoA-transferase activity" RELATED [EC:2.8.3.10] +xref: EC:2.8.3.10 +xref: MetaCyc:CITTRANS-RXN +xref: RHEA:19405 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0008815 +name: citrate (pro-3S)-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [RHEA:10760] +synonym: "citrase activity" RELATED [EC:4.1.3.6] +synonym: "citratase activity" RELATED [EC:4.1.3.6] +synonym: "citrate aldolase activity" RELATED [EC:4.1.3.6] +synonym: "citrate lyase" NARROW [] +synonym: "citrate lyase activity" EXACT [] +synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] +synonym: "citrate oxaloacetate-lyase activity" RELATED [EC:4.1.3.6] +synonym: "citric aldolase activity" RELATED [EC:4.1.3.6] +synonym: "citridesmolase activity" RELATED [EC:4.1.3.6] +synonym: "citritase activity" RELATED [EC:4.1.3.6] +xref: EC:4.1.3.6 +xref: KEGG_REACTION:R00362 +xref: MetaCyc:CITLY-RXN +xref: RHEA:10760 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008816 +name: citryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] +synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.34] +synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" RELATED [EC:4.1.3.34] +xref: EC:4.1.3.34 +xref: MetaCyc:CITRYLY-RXN +xref: RHEA:20812 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008817 +name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] +synonym: "aquacob(I)alamin adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "ATP:corrinoid adenosyltransferase activity" RELATED [EC:2.5.1.17] +synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] +synonym: "CobA" RELATED [EC:2.5.1.17] +synonym: "vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] +xref: EC:2.5.1.17 +xref: MetaCyc:COBALADENOSYLTRANS-RXN +xref: Reactome:R-HSA-3159253 "MMAB transfers adenosyl group from ATP to cob(I)alamin" +xref: Reactome:R-HSA-3322125 "Defective MMAB does not transfer adenosyl group from ATP to B12s" +xref: RHEA:14725 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008818 +name: cobalamin 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] +xref: MetaCyc:COBALAMIN5PSYN-RXN +xref: RHEA:23560 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008819 +name: cobinamide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008820 +name: cobinamide phosphate guanylyltransferase activity +namespace: molecular_function +alt_id: GO:0043753 +def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate." [EC:2.7.7.62, RHEA:22712] +synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] +synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] +synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] +synonym: "CobU" RELATED [] +synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] +synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] +xref: EC:2.7.7.62 +xref: KEGG_REACTION:R05222 +xref: MetaCyc:COBINPGUANYLYLTRANS-RXN +xref: RHEA:22712 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0008821 +name: crossover junction endodeoxyribonuclease activity +namespace: molecular_function +alt_id: GO:0008844 +def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] +synonym: "crossover junction endoribonuclease activity" EXACT [] +synonym: "cruciform-cutting endonuclease activity" RELATED [EC:3.1.22.-] +synonym: "endo X3" RELATED [EC:3.1.22.4] +synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] +synonym: "endodeoxyribonuclease RUS activity" EXACT [] +synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] +synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] +synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] +synonym: "Hje endonuclease activity" RELATED [EC:3.1.22.-] +synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] +synonym: "Holliday junction nuclease activity" RELATED [EC:3.1.22.-] +synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +synonym: "Holliday junction-cleaving endonuclease activity" RELATED [EC:3.1.22.-] +synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] +synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] +synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] +synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] +synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] +synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] +synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] +xref: EC:3.1.22.4 +xref: MetaCyc:3.1.22.4-RXN +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0008822 +name: obsolete crotonobetaine/carnitine-CoA ligase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a bifunctional gene product. +synonym: "crotonobetaine/carnitine-CoA ligase activity" EXACT [] +is_obsolete: true +consider: GO:0051108 +consider: GO:0051109 + +[Term] +id: GO:0008823 +name: cupric reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH." [PMID:10510271] +xref: EC:1.16.1.- +xref: MetaCyc:R170-RXN +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0008824 +name: cyanate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104, RHEA:11120] +comment: Note that this function was formerly EC:4.3.99.1. +synonym: "carbamate hydro-lyase activity" RELATED [EC:4.2.1.104] +synonym: "cyanase activity" EXACT [] +synonym: "cyanate aminohydrolase activity" RELATED [EC:4.2.1.104] +synonym: "cyanate C-N-lyase activity" RELATED [EC:4.2.1.104] +synonym: "cyanate hydrolase activity" RELATED [EC:4.2.1.104] +synonym: "cyanate lyase activity" EXACT [] +xref: EC:4.2.1.104 +xref: MetaCyc:R524-RXN +xref: RHEA:11120 +xref: UM-BBD_reactionID:r0608 +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0008825 +name: cyclopropane-fatty-acyl-phospholipid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] +synonym: "CFA synthase activity" RELATED [EC:2.1.1.79] +synonym: "cyclopropane fatty acid synthase activity" RELATED [EC:2.1.1.79] +synonym: "cyclopropane fatty acid synthetase activity" RELATED [EC:2.1.1.79] +synonym: "cyclopropane synthase activity" RELATED [EC:2.1.1.79] +synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] +synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" RELATED [EC:2.1.1.79] +synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] +xref: EC:2.1.1.79 +xref: MetaCyc:2.1.1.79-RXN +xref: RHEA:11988 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008826 +name: cysteine sulfinate desulfinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [RHEA:28278] +synonym: "cysteine sulphinate desulphinase activity" EXACT [] +xref: MetaCyc:RXN0-279 +xref: RHEA:28278 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0008828 +name: dATP pyrophosphohydrolase activity +namespace: molecular_function +alt_id: GO:0044713 +alt_id: GO:0044714 +def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [GOC:pde, PMID:11139615] +synonym: "2-hydroxy-(d)ATP pyrophosphatase activity" EXACT [] +synonym: "2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity" EXACT [] +synonym: "2-hydroxy-adenosine triphosphate pyrophosphatase activity" RELATED [] +synonym: "2-hydroxy-ATP pyrophosphatase activity" RELATED [] +xref: EC:3.6.1.56 +xref: MetaCyc:RXN0-384 +xref: Reactome:R-HSA-2395818 "NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP" +xref: Reactome:R-HSA-2395872 "NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP" +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0008829 +name: dCTP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] +synonym: "5-methyl-dCTP deaminase activity" RELATED [EC:3.5.4.13] +synonym: "dCTP aminohydrolase activity" RELATED [EC:3.5.4.13] +synonym: "deoxycytidine triphosphate deaminase activity" RELATED [EC:3.5.4.13] +xref: EC:3.5.4.13 +xref: MetaCyc:DCTP-DEAM-RXN +xref: Reactome:R-HSA-180632 "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand" +xref: RHEA:22680 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008830 +name: dTDP-4-dehydrorhamnose 3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16969] +synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" RELATED [EC:5.1.3.13] +synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" RELATED [EC:5.1.3.13] +synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" RELATED [EC:5.1.3.13] +synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] +synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] +xref: EC:5.1.3.13 +xref: KEGG_REACTION:R06514 +xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN +xref: RHEA:16969 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0008831 +name: dTDP-4-dehydrorhamnose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21796] +synonym: "dTDP-4-keto-L-rhamnose reductase activity" RELATED [EC:1.1.1.133] +synonym: "dTDP-4-ketorhamnose reductase activity" RELATED [EC:1.1.1.133] +synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" RELATED [EC:1.1.1.133] +synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.133] +synonym: "reductase, thymidine diphospho-4-ketorhamnose" RELATED [EC:1.1.1.133] +synonym: "TDP-4-keto-rhamnose reductase activity" RELATED [EC:1.1.1.133] +synonym: "thymidine diphospho-4-ketorhamnose reductase activity" RELATED [EC:1.1.1.133] +xref: EC:1.1.1.133 +xref: KEGG_REACTION:R02777 +xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN +xref: RHEA:21796 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008832 +name: dGTPase activity +namespace: molecular_function +def: "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate." [EC:3.1.5.1, RHEA:15193] +synonym: "deoxy-GTPase activity" RELATED [EC:3.1.5.1] +synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" RELATED [EC:3.1.5.1] +synonym: "deoxyguanosine triphosphatase activity" RELATED [EC:3.1.5.1] +synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" RELATED [EC:3.1.5.1] +synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] +synonym: "dGTP triphosphohydrolase activity" RELATED [EC:3.1.5.1] +xref: EC:3.1.5.1 +xref: KEGG_REACTION:R01856 +xref: MetaCyc:DGTPTRIPHYDRO-RXN +xref: RHEA:15193 +is_a: GO:0016793 ! triphosphoric monoester hydrolase activity + +[Term] +id: GO:0008833 +name: deoxyribonuclease IV (phage-T4-induced) activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] +synonym: "deoxriboendonuclease activity" RELATED [EC:3.1.21.2] +synonym: "deoxyribonuclease IV (phage T4-induced) activity" RELATED [EC:3.1.21.2] +synonym: "DNA-adenine-transferase activity" RELATED [EC:3.1.21.2] +synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] +synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" RELATED [EC:3.1.21.2] +synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" RELATED [EC:3.1.21.2] +synonym: "endonuclease II" RELATED [EC:3.1.21.2] +synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] +synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] +synonym: "redoxyendonuclease activity" RELATED [EC:3.1.21.2] +xref: EC:3.1.21.2 +xref: MetaCyc:3.1.21.2-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008834 +name: di-trans,poly-cis-decaprenylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] +synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] +synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" RELATED [EC:2.5.1.31] +synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] +synonym: "undecaprenyl diphosphate synthase activity" EXACT [] +synonym: "undecaprenyl diphosphate synthetase activity" RELATED [EC:2.5.1.31] +synonym: "undecaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.31] +synonym: "undecaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.31] +synonym: "undecaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] +synonym: "UPP synthetase activity" RELATED [EC:2.5.1.31] +xref: EC:2.5.1.31 +xref: MetaCyc:RXN-8999 +xref: RHEA:27551 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0008835 +name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity +namespace: molecular_function +alt_id: GO:0008485 +def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [EC:3.5.4.26, RHEA:21868] +synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] +synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" RELATED [EC:3.5.4.26] +synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" RELATED [EC:3.5.4.26] +xref: EC:3.5.4.26 +xref: KEGG_REACTION:R03459 +xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN +xref: RHEA:21868 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008836 +name: diaminopimelate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15101] +synonym: "DAP decarboxylase activity" RELATED [EC:4.1.1.20] +synonym: "DAP-decarboxylase activity" RELATED [EC:4.1.1.20] +synonym: "diaminopimelic acid decarboxylase activity" RELATED [EC:4.1.1.20] +synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" RELATED [EC:4.1.1.20] +synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" RELATED [EC:4.1.1.20] +synonym: "meso-diaminopimelate decarboxylase activity" RELATED [EC:4.1.1.20] +xref: EC:4.1.1.20 +xref: KEGG_REACTION:R00451 +xref: MetaCyc:DIAMINOPIMDECARB-RXN +xref: RHEA:15101 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008837 +name: diaminopimelate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15393] +synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" RELATED [EC:5.1.1.7] +xref: EC:5.1.1.7 +xref: KEGG_REACTION:R02735 +xref: MetaCyc:DIAMINOPIMEPIM-RXN +xref: RHEA:15393 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0008838 +name: diaminopropionate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] +synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" RELATED [EC:4.3.1.15] +synonym: "2,3-diaminopropionate ammonia-lyase activity" RELATED [EC:4.3.1.15] +synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" RELATED [EC:4.3.1.15] +synonym: "diaminopropionatase activity" RELATED [EC:4.3.1.15] +xref: EC:4.3.1.15 +xref: MetaCyc:4.3.1.15-RXN +xref: RHEA:22084 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008839 +name: 4-hydroxy-tetrahydrodipicolinate reductase +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8] +synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.26] +synonym: "dihydrodipicolinate reductase activity" EXACT [] +synonym: "dihydrodipicolinic acid reductase activity" RELATED [EC:1.3.1.26] +xref: EC:1.17.1.8 +xref: MetaCyc:DIHYDROPICRED-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008840 +name: 4-hydroxy-tetrahydrodipicolinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14845] +synonym: "DHDPS activity" RELATED [EC:4.2.1.52] +synonym: "dihydrodipicolinate synthase activity" EXACT [] +synonym: "dihydrodipicolinate synthetase activity" RELATED [EC:4.2.1.52] +synonym: "dihydrodipicolinic acid synthase activity" RELATED [EC:4.2.1.52] +synonym: "dihydropicolinate synthetase activity" RELATED [EC:4.2.1.52] +synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" RELATED [EC:4.2.1.52] +synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] +xref: EC:4.3.3.7 +xref: KEGG_REACTION:R02292 +xref: MetaCyc:DIHYDRODIPICSYN-RXN +xref: RHEA:14845 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008841 +name: dihydrofolate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] +synonym: "7,8-dihydrofolate synthetase activity" RELATED [EC:6.3.2.12] +synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" RELATED [EC:6.3.2.12] +synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" RELATED [EC:6.3.2.12] +synonym: "DHFS activity" RELATED [EC:6.3.2.12] +synonym: "dihydrofolate synthetase activity" RELATED [EC:6.3.2.12] +synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" RELATED [EC:6.3.2.12] +synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" RELATED [EC:6.3.2.12] +synonym: "FHFS activity" RELATED [EC:6.3.2.12] +synonym: "FHFS/FPGS activity" RELATED [EC:6.3.2.12] +synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" RELATED [EC:6.3.2.12] +synonym: "H(2)-folate synthetase activity" RELATED [EC:6.3.2.12] +synonym: "H2-folate synthetase activity" RELATED [EC:6.3.2.12] +xref: EC:6.3.2.12 +xref: MetaCyc:DIHYDROFOLATESYNTH-RXN +xref: RHEA:23584 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0008842 +name: diphosphate-purine nucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] +synonym: "diphosphate-dependent nucleoside kinase activity" RELATED [EC:2.7.1.143] +synonym: "diphosphate:purine nucleoside phosphotransferase activity" RELATED [EC:2.7.1.143] +synonym: "pyrophosphate-dependent nucleoside kinase activity" RELATED [EC:2.7.1.143] +synonym: "pyrophosphate-purine nucleoside kinase activity" RELATED [EC:2.7.1.143] +xref: EC:2.7.1.143 +xref: MetaCyc:2.7.1.143-RXN +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0008843 +name: endochitinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] +is_a: GO:0004568 ! chitinase activity + +[Term] +id: GO:0008845 +name: obsolete endonuclease VIII activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12713806] +comment: This term was made obsolete because it represents a gene product. +synonym: "endonuclease VIII activity" EXACT [] +is_obsolete: true +consider: GO:0000703 +consider: GO:0003684 +consider: GO:0003906 +consider: GO:0004519 +consider: GO:0008081 +consider: GO:0019104 + +[Term] +id: GO:0008846 +name: obsolete endopeptidase La activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP-dependent lon proteinase" NARROW [] +synonym: "ATP-dependent protease La activity" RELATED [] +synonym: "ATP-dependent serine proteinase activity" RELATED [] +synonym: "endopeptidase La activity" EXACT [] +synonym: "Escherichia coli proteinase La" RELATED [] +synonym: "Escherichia coli serine proteinase La" RELATED [] +synonym: "gene lon protease activity" RELATED [] +synonym: "gene lon proteins" RELATED [] +synonym: "lon proteinase" NARROW [] +synonym: "PIM1 protease activity" RELATED [] +synonym: "PIM1 proteinase activity" RELATED [] +synonym: "protease La" RELATED [] +synonym: "proteinase La" RELATED [] +synonym: "serine protease La" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008847 +name: Enterobacter ribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.21] +synonym: "Enterobacter RNase activity" EXACT [] +xref: EC:4.6.1.21 +xref: MetaCyc:3.1.27.6-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0008848 +name: obsolete enterobactin synthetase +namespace: molecular_function +alt_id: GO:0008850 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a process rather than a function. +synonym: "enterobactin synthetase" EXACT [] +synonym: "enterochelin synthetase activity" EXACT [] +synonym: "nonribosomal peptide synthetase" RELATED [] +is_obsolete: true +replaced_by: GO:0009239 + +[Term] +id: GO:0008849 +name: enterochelin esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531] +synonym: "enterobactin esterase activity" EXACT [] +xref: MetaCyc:RXN0-1661 +xref: RHEA:28018 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0008851 +name: ethanolamine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] +synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" RELATED [EC:4.3.1.7] +synonym: "ethanolamine deaminase activity" RELATED [EC:4.3.1.7] +xref: EC:4.3.1.7 +xref: MetaCyc:ETHAMLY-RXN +xref: RHEA:15313 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0008852 +name: exodeoxyribonuclease I activity +namespace: molecular_function +def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] +synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] +synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] +synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] +synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] +xref: EC:3.1.11.1 +xref: MetaCyc:3.1.11.1-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008853 +name: exodeoxyribonuclease III activity +namespace: molecular_function +def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] +synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] +synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] +synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] +synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] +synonym: "exonuclease III activity" RELATED [EC:3.1.11.2] +xref: EC:3.1.11.2 +xref: MetaCyc:3.1.11.2-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008854 +name: exodeoxyribonuclease V activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] +synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] +synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] +synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] +synonym: "exonuclease V activity" RELATED [EC:3.1.11.5] +synonym: "gene recBC DNase activity" RELATED [EC:3.1.11.5] +synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] +synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] +synonym: "RecBC deoxyribonuclease activity" RELATED [EC:3.1.11.5] +xref: EC:3.1.11.5 +xref: MetaCyc:3.1.11.5-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008855 +name: exodeoxyribonuclease VII activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] +synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] +synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] +synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] +synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] +synonym: "exonuclease VII activity" RELATED [EC:3.1.11.6] +xref: EC:3.1.11.6 +xref: MetaCyc:3.1.11.6-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008856 +name: exodeoxyribonuclease X activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] +synonym: "deoxyribonuclease X activity" RELATED [EC:3.1.22.5] +synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] +synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] +xref: EC:3.1.11.- +xref: MetaCyc:3.1.22.5-RXN +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008859 +name: exoribonuclease II activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] +synonym: "5'-exoribonuclease activity" RELATED [EC:3.1.13.1] +synonym: "BN ribonuclease activity" RELATED [EC:3.1.13.1] +synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] +synonym: "ribonuclease II activity" RELATED [EC:3.1.13.1] +synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] +synonym: "RNase II" RELATED [EC:3.1.13.1] +synonym: "RNase II activity" EXACT [] +xref: EC:3.1.13.1 +xref: MetaCyc:3.1.13.1-RXN +is_a: GO:0008408 ! 3'-5' exonuclease activity +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0008860 +name: ferredoxin-NAD+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [RHEA:16521] +synonym: "ferredoxin-linked NAD reductase activity" RELATED [EC:1.18.1.3] +synonym: "ferredoxin-NAD reductase activity" EXACT [] +synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" RELATED [EC:1.18.1.3] +synonym: "ferredoxin:NAD+ oxidoreductase activity" RELATED [EC:1.18.1.3] +synonym: "NAD-ferredoxin reductase activity" RELATED [EC:1.18.1.3] +synonym: "NADH flavodoxin oxidoreductase activity" RELATED [EC:1.18.1.3] +synonym: "NADH-ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.3] +synonym: "NADH-ferredoxin reductase activity" RELATED [EC:1.18.1.3] +synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" RELATED [EC:1.18.1.3] +synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" RELATED [EC:1.18.1.3] +synonym: "NADH2-ferredoxin oxidoreductase activity" RELATED [EC:1.18.1.3] +synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" RELATED [EC:1.18.1.3] +xref: EC:1.18.1.3 +xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN +xref: RHEA:16521 +is_a: GO:0008937 ! ferredoxin-NAD(P) reductase activity + +[Term] +id: GO:0008861 +name: formate C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] +synonym: "acetyl-CoA:formate C-acetyltransferase activity" RELATED [EC:2.3.1.54] +synonym: "formate acetyltransferase activity" RELATED [EC:2.3.1.54] +synonym: "PFL" EXACT [] +synonym: "pyruvate formate-lyase activity" RELATED [EC:2.3.1.54] +synonym: "pyruvate formate:lyase activity" EXACT [] +synonym: "pyruvic formate-lyase activity" RELATED [EC:2.3.1.54] +xref: EC:2.3.1.54 +xref: MetaCyc:PYRUVFORMLY-RXN +xref: RHEA:11844 +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0008863 +name: formate dehydrogenase (NAD+) activity +namespace: molecular_function +alt_id: GO:0018476 +def: "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [EC:1.17.1.9, RHEA:15985] +synonym: "formate dehydrogenase (NAD)" RELATED [EC:1.17.1.9] +synonym: "formate hydrogenlyase" RELATED [EC:1.17.1.9] +synonym: "formate-NAD oxidoreductase" RELATED [] +synonym: "formic acid dehydrogenase" RELATED [EC:1.17.1.9] +synonym: "formic hydrogen-lyase" RELATED [EC:1.17.1.9] +synonym: "NAD-dependent formate dehydrogenase" RELATED [] +synonym: "NAD-formate dehydrogenase" RELATED [EC:1.17.1.9] +xref: EC:1.17.1.9 +xref: KEGG_REACTION:R00519 +xref: MetaCyc:1.2.1.2-RXN +xref: MetaCyc:FORMATEDEHYDROG-RXN +xref: RHEA:15985 +xref: UM-BBD_reactionID:r0103 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008864 +name: formyltetrahydrofolate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)." [EC:3.5.1.10, RHEA:19833] +synonym: "10-formyltetrahydrofolate amidohydrolase activity" RELATED [EC:3.5.1.10] +synonym: "formyl-FH(4) hydrolase activity" RELATED [EC:3.5.1.10] +synonym: "formyltetrahydrofolate hydrolase activity" RELATED [EC:3.5.1.10] +xref: EC:3.5.1.10 +xref: KEGG_REACTION:R00944 +xref: MetaCyc:FORMYLTHFDEFORMYL-RXN +xref: RHEA:19833 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008865 +name: fructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] +synonym: "ATP:D-fructose 6-phosphotransferase activity" RELATED [EC:2.7.1.4] +synonym: "D-fructokinase activity" RELATED [EC:2.7.1.4] +synonym: "D-fructose(D-mannose)kinase activity" RELATED [EC:2.7.1.4] +synonym: "fructokinase (phosphorylating)" RELATED [EC:2.7.1.4] +xref: EC:2.7.1.4 +xref: MetaCyc:FRUCTOKINASE-RXN +xref: RHEA:16125 +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0008866 +name: fructuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH." [EC:1.1.1.57, RHEA:15729] +synonym: "D-mannonate dehydrogenase activity" RELATED [EC:1.1.1.57] +synonym: "D-mannonate oxidoreductase activity" RELATED [EC:1.1.1.57] +synonym: "D-mannonate:NAD oxidoreductase activity" RELATED [EC:1.1.1.57] +synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.57] +synonym: "mannonate oxidoreductase activity" RELATED [EC:1.1.1.57] +synonym: "mannonic dehydrogenase activity" RELATED [EC:1.1.1.57] +xref: EC:1.1.1.57 +xref: KEGG_REACTION:R02454 +xref: MetaCyc:MANNONOXIDOREDUCT-RXN +xref: RHEA:15729 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008867 +name: galactarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [EC:4.2.1.42, RHEA:16005] +synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" RELATED [EC:4.2.1.42] +synonym: "D-galactarate hydro-lyase activity" RELATED [EC:4.2.1.42] +xref: EC:4.2.1.42 +xref: KEGG_REACTION:R05608 +xref: MetaCyc:GALACTARDEHYDRA-RXN +xref: RHEA:16005 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008868 +name: galactitol-1-phosphate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] +synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.251] +xref: EC:1.1.1.251 +xref: MetaCyc:1.1.1.251-RXN +xref: RHEA:15137 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008869 +name: galactonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O." [EC:4.2.1.6, RHEA:18649] +synonym: "D-galactonate dehydrase activity" RELATED [EC:4.2.1.6] +synonym: "D-galactonate dehydratase activity" RELATED [EC:4.2.1.6] +synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" RELATED [EC:4.2.1.6] +synonym: "D-galactonate hydro-lyase activity" RELATED [EC:4.2.1.6] +xref: EC:4.2.1.6 +xref: KEGG_REACTION:R03033 +xref: MetaCyc:GALACTONDEHYDRAT-RXN +xref: RHEA:18649 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008870 +name: galactoside O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] +synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" RELATED [EC:2.3.1.18] +synonym: "galactoside acetyltransferase activity" RELATED [EC:2.3.1.18] +synonym: "thiogalactoside acetyltransferase activity" RELATED [EC:2.3.1.18] +synonym: "thiogalactoside transacetylase activity" RELATED [EC:2.3.1.18] +xref: EC:2.3.1.18 +xref: MetaCyc:GALACTOACETYLTRAN-RXN +xref: RHEA:15713 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008871 +name: aminoglycoside 2''-nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] +synonym: "2''-aminoglycoside nucleotidyltransferase activity" RELATED [EC:2.7.7.46] +synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] +xref: EC:2.7.7.46 +xref: MetaCyc:2.7.7.46-RXN +is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity + +[Term] +id: GO:0008872 +name: glucarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] +synonym: "D-glucarate dehydratase activity" RELATED [EC:4.2.1.40] +synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" RELATED [EC:4.2.1.40] +synonym: "D-glucarate hydro-lyase activity" RELATED [EC:4.2.1.40] +xref: EC:4.2.1.40 +xref: MetaCyc:GLUCARDEHYDRA-RXN +xref: RHEA:14573 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008873 +name: gluconate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] +synonym: "2-keto-D-gluconate reductase activity" RELATED [EC:1.1.1.215] +synonym: "2-ketogluconate reductase activity" RELATED [EC:1.1.1.215] +synonym: "D-gluconate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.215] +xref: EC:1.1.1.215 +xref: MetaCyc:1.1.1.215-RXN +xref: RHEA:16653 +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0008874 +name: gluconate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] +synonym: "5-keto-D-gluconate 5-reductase activity" RELATED [EC:1.1.1.69] +synonym: "5-keto-D-gluconate reductase" RELATED [EC:1.1.1.69] +synonym: "5-ketogluconate 5-reductase activity" RELATED [EC:1.1.1.69] +synonym: "5-ketogluconate reductase activity" RELATED [EC:1.1.1.69] +synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" RELATED [EC:1.1.1.69] +xref: EC:1.1.1.69 +xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0008875 +name: gluconate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008876 +name: quinoprotein glucose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] +comment: Formerly EC:1.1.99.17. +synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" RELATED [EC:1.1.5.2] +synonym: "D-glucose:ubiquinone oxidoreductase activity" RELATED [EC:1.1.5.2] +synonym: "glucose dehydrogenase (PQQ-dependent) activity" RELATED [EC:1.1.5.2] +synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] +synonym: "quinoprotein D-glucose dehydrogenase activity" RELATED [EC:1.1.5.2] +xref: EC:1.1.5.2 +xref: MetaCyc:GLUCDEHYDROG-RXN +xref: RHEA:22152 +is_a: GO:0004344 ! glucose dehydrogenase activity +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0008877 +name: glucose-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] +synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.10] +synonym: "D-glucose-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.10] +xref: EC:3.1.3.10 +xref: KEGG_REACTION:R00304 +xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN +xref: RHEA:19933 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0008878 +name: glucose-1-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12120] +synonym: "adenosine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27] +synonym: "adenosine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.27] +synonym: "ADGase activity" EXACT [] +synonym: "ADP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27] +synonym: "ADP-glucose diphosphorylase activity" RELATED [EC:2.7.7.27] +synonym: "ADP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.27] +synonym: "ADP-glucose synthase activity" RELATED [EC:2.7.7.27] +synonym: "ADP-glucose synthetase activity" RELATED [EC:2.7.7.27] +synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27] +synonym: "ADPG pyrophosphorylase activity" EXACT [] +synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27] +synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] +synonym: "glucose 1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.27] +xref: EC:2.7.7.27 +xref: KEGG_REACTION:R00948 +xref: MetaCyc:GLUC1PADENYLTRANS-RXN +xref: RHEA:12120 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0008879 +name: glucose-1-phosphate thymidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15225] +synonym: "dTDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.24] +synonym: "dTDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24] +synonym: "dTDP-glucose synthase activity" RELATED [EC:2.7.7.24] +synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.24] +synonym: "glucose 1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.24] +synonym: "TDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24] +synonym: "thymidine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.24] +synonym: "thymidine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.24] +xref: EC:2.7.7.24 +xref: KEGG_REACTION:R02328 +xref: MetaCyc:DTDPGLUCOSEPP-RXN +xref: RHEA:15225 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0008880 +name: glucuronate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] +synonym: "D-glucuronate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.12] +synonym: "D-glucuronate isomerase activity" RELATED [EC:5.3.1.12] +synonym: "D-glucuronate ketol-isomerase activity" RELATED [EC:5.3.1.12] +synonym: "uronate isomerase activity" RELATED [EC:5.3.1.12] +synonym: "uronic acid isomerase activity" RELATED [EC:5.3.1.12] +synonym: "uronic isomerase activity" RELATED [EC:5.3.1.12] +xref: EC:5.3.1.12 +xref: MetaCyc:GLUCUROISOM-RXN +xref: RHEA:13049 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008881 +name: glutamate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12813] +xref: EC:5.1.1.3 +xref: KEGG_REACTION:R00260 +xref: MetaCyc:GLUTRACE-RXN +xref: RHEA:12813 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0008882 +name: [glutamate-ammonia-ligase] adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42] +synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42] +synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] +synonym: "ATP:glutamine synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42] +synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" RELATED [EC:2.7.7.42] +synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] +synonym: "glutamine-synthetase adenylyltransferase activity" RELATED [EC:2.7.7.42] +xref: EC:2.7.7.42 +xref: MetaCyc:GSADENYLATION-RXN +xref: RHEA:18589 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0008883 +name: glutamyl-tRNA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH." [EC:1.2.1.70, RHEA:12344] +synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" RELATED [EC:1.2.1.70] +xref: EC:1.2.1.70 +xref: KEGG_REACTION:R04109 +xref: MetaCyc:GLUTRNAREDUCT-RXN +xref: RHEA:12344 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0008884 +name: glutathionylspermidine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" RELATED [EC:3.5.1.78] +synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" RELATED [EC:3.5.1.78] +synonym: "GSP amidase activity" RELATED [EC:3.5.1.78] +xref: EC:3.5.1.78 +xref: MetaCyc:GSPAMID-RXN +xref: RHEA:17173 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008885 +name: glutathionylspermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] +synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" RELATED [EC:6.3.1.8] +synonym: "glutathione:spermidine ligase (ADP-forming) activity" RELATED [EC:6.3.1.8] +synonym: "glutathionylspermidine synthetase activity" RELATED [EC:6.3.1.8] +synonym: "GSP synthetase activity" RELATED [EC:6.3.1.8] +xref: EC:6.3.1.8 +xref: MetaCyc:GSPSYN-RXN +xref: RHEA:21272 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0008886 +name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH." [EC:1.2.1.9, RHEA:14669] +synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] +synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] +synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] +synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] +synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] +synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] +synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] +xref: EC:1.2.1.9 +xref: KEGG_REACTION:R01058 +xref: MetaCyc:1.2.1.9-RXN +xref: RHEA:14669 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008887 +name: glycerate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23516] +synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" RELATED [EC:2.7.1.31] +synonym: "ATP:D-glycerate 2-phosphotransferase activity" RELATED [EC:2.7.1.31] +synonym: "D-glycerate 3-kinase activity" RELATED [EC:2.7.1.31] +synonym: "D-glycerate kinase activity" RELATED [EC:2.7.1.31] +synonym: "D-glyceric acid kinase activity" RELATED [EC:2.7.1.31] +synonym: "GK" RELATED [EC:2.7.1.31] +synonym: "glycerate kinase (phosphorylating)" RELATED [EC:2.7.1.31] +synonym: "glycerate-3-kinase activity" RELATED [EC:2.7.1.31] +xref: EC:2.7.1.31 +xref: KEGG_REACTION:R01514 +xref: MetaCyc:GLY3KIN-RXN +xref: Reactome:R-HSA-6799495 "GLYCTK phosphorylates DGA to 3PDGA" +xref: RHEA:23516 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008888 +name: glycerol dehydrogenase [NAD+] activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13769] +synonym: "glycerol dehydrogenase activity" BROAD [] +synonym: "NAD-linked glycerol dehydrogenase activity" RELATED [EC:1.1.1.6] +xref: EC:1.1.1.6 +xref: KEGG_REACTION:R01034 +xref: MetaCyc:GLYCDEH-RXN +xref: RHEA:13769 +is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0008889 +name: glycerophosphodiester phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] +synonym: "gene hpd protein" RELATED [EC:3.1.4.46] +synonym: "glycerophosphodiester glycerophosphohydrolase activity" RELATED [EC:3.1.4.46] +synonym: "glycerophosphoryl diester phosphodiesterase activity" RELATED [EC:3.1.4.46] +synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] +xref: EC:3.1.4.46 +xref: MetaCyc:GLYCPDIESTER-RXN +xref: Reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1" +xref: Reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1" +xref: RHEA:12969 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0008890 +name: glycine C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20736] +synonym: "2-amino-3-ketobutyrate CoA ligase activity" RELATED [EC:2.3.1.29] +synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" RELATED [EC:2.3.1.29] +synonym: "2-amino-3-ketobutyrate-CoA ligase activity" RELATED [EC:2.3.1.29] +synonym: "acetyl-CoA:glycine C-acetyltransferase activity" RELATED [EC:2.3.1.29] +synonym: "aminoacetone synthase activity" RELATED [EC:2.3.1.29] +synonym: "glycine acetyltransferase activity" RELATED [EC:2.3.1.29] +xref: EC:2.3.1.29 +xref: KEGG_REACTION:R00371 +xref: MetaCyc:AKBLIG-RXN +xref: RHEA:20736 +is_a: GO:0016453 ! C-acetyltransferase activity + +[Term] +id: GO:0008892 +name: guanine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] +synonym: "GAH activity" RELATED [EC:3.5.4.3] +synonym: "guanase activity" RELATED [EC:3.5.4.3] +synonym: "guanine aminase activity" RELATED [EC:3.5.4.3] +synonym: "guanine aminohydrolase activity" RELATED [EC:3.5.4.3] +xref: EC:3.5.4.3 +xref: MetaCyc:GUANINE-DEAMINASE-RXN +xref: Reactome:R-HSA-74255 "Guanine + H2O => Xanthine + NH4+" +xref: RHEA:14665 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0008893 +name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] +synonym: "(ppGpp)ase activity" RELATED [EC:3.1.7.2] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" RELATED [EC:3.1.7.2] +synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] +synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" RELATED [EC:3.1.7.2] +synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" RELATED [EC:3.1.7.2] +synonym: "PpGpp phosphohydrolase activity" RELATED [EC:3.1.7.2] +synonym: "PpGpp-3'-pyrophosphohydrolase activity" RELATED [EC:3.1.7.2] +xref: EC:3.1.7.2 +xref: MetaCyc:PPGPPSYN-RXN +xref: RHEA:14253 +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0008894 +name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] +synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine pentaphosphatase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine pentaphosphate phosphatase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine pentaphosphate phosphohydrolase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40] +synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] +synonym: "pppGpp 5'-phosphohydrolase activity" RELATED [EC:3.6.1.40] +xref: EC:3.6.1.40 +xref: MetaCyc:PPPGPPHYDRO-RXN +xref: RHEA:13073 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0008897 +name: holo-[acyl-carrier-protein] synthase activity +namespace: molecular_function +alt_id: GO:0008958 +def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] +synonym: "4'-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7] +synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] +synonym: "AcpS" RELATED [EC:2.7.8.7] +synonym: "ACPS activity" RELATED [EC:2.7.8.7] +synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" RELATED [EC:2.7.8.7] +synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] +synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] +synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] +synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7] +synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" RELATED [EC:2.7.8.7] +synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" RELATED [EC:2.7.8.7] +synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" RELATED [EC:2.7.8.7] +synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" RELATED [EC:2.7.8.7] +synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] +synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] +synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] +synonym: "holo-acyl-carrier-protein synthase activity" RELATED [EC:2.7.8.7] +synonym: "holosynthase activity" RELATED [EC:2.7.8.7] +synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] +synonym: "P-pant transferase activity" RELATED [EC:2.7.8.7] +synonym: "phosphopantetheinyl transferase" RELATED [] +synonym: "phosphopantetheinyltransferase activity" EXACT [] +synonym: "PPTase activity" RELATED [EC:2.7.8.7] +xref: EC:2.7.8.7 +xref: MetaCyc:HOLO-ACP-SYNTH-RXN +xref: Reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS" +xref: RHEA:12068 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008898 +name: S-adenosylmethionine-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] +synonym: "adenosylmethionine transmethylase activity" RELATED [EC:2.1.1.10] +synonym: "adenosylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10] +synonym: "L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "S-adenosylmethionine homocysteine transmethylase activity" RELATED [EC:2.1.1.10] +synonym: "S-adenosylmethionine-homocysteine transmethylase activity" RELATED [EC:2.1.1.10] +synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN +xref: RHEA:21820 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008899 +name: homoserine O-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22008] +synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] +synonym: "homoserine succinyltransferase activity" RELATED [EC:2.3.1.46] +synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" RELATED [EC:2.3.1.46] +xref: EC:2.3.1.46 +xref: KEGG_REACTION:R01777 +xref: MetaCyc:HOMSUCTRAN-RXN +xref: RHEA:22008 +is_a: GO:0016750 ! O-succinyltransferase activity + +[Term] +id: GO:0008900 +name: P-type potassium:proton transporter activity +namespace: molecular_function +alt_id: GO:0005390 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [RHEA:22044] +synonym: "(K+ + H+)-ATPase activity" RELATED [EC:7.2.2.19] +synonym: "ATP phosphohydrolase (H+/K+-exchanging)" RELATED [EC:7.2.2.19] +synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] +synonym: "gastric H+/K+ ATPase" NARROW [EC:7.2.2.19] +synonym: "H(+)/K(+)-ATPase activity" RELATED [EC:7.2.2.19] +synonym: "H(+)/K(+)-exchanging ATPase activity" RELATED [EC:7.2.2.19] +synonym: "H+-K+-ATPase activity" RELATED [EC:7.2.2.19] +synonym: "H+/K+-ATPase activity" RELATED [EC:7.2.2.19] +synonym: "H+/K+-exchanging ATPase activity" RELATED [EC:7.2.2.19] +synonym: "H,K-ATPase activity" RELATED [EC:7.2.2.19] +synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] +synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] +synonym: "hydrogen:potassium-exchanging ATPase activity" EXACT [] +synonym: "potassium:proton exchanging ATPase activity" RELATED [] +synonym: "proton pump activity" BROAD [EC:3.6.3.10] +xref: EC:7.2.2.19 +xref: Reactome:R-HSA-937311 "ATP4A/12A:ATP4B exchanges K+ for H+" +xref: RHEA:22044 +is_a: GO:0008553 ! P-type proton-exporting transporter activity +is_a: GO:0008556 ! P-type potassium transmembrane transporter activity + +[Term] +id: GO:0008901 +name: ferredoxin hydrogenase activity +namespace: molecular_function +alt_id: GO:0016948 +alt_id: GO:0016949 +alt_id: GO:0016950 +alt_id: GO:0016951 +def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] +comment: Note that this function was formerly EC:1.12.1.1, EC:1.12.7.1, EC:1.98.1.1, EC:1.18.3.1 and EC:1.18.99.1. +synonym: "[Fe] hydrogenase activity" EXACT [] +synonym: "[Fe] hydrogenase gamma" RELATED [] +synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] +synonym: "H2 oxidizing hydrogenase" BROAD [] +synonym: "H2 producing hydrogenase" BROAD [] +synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] +synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] +synonym: "hydrogenase (ferredoxin) activity" RELATED [EC:1.12.7.2] +synonym: "hydrogenase activity" BROAD [] +synonym: "hydrogenase I" RELATED [] +synonym: "hydrogenase II" RELATED [] +synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] +synonym: "iron hydrogenase activity" NARROW [] +synonym: "iron-only hydrogenase activity" NARROW [] +synonym: "Ni-Fe hydrogenase activity" NARROW [] +synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] +synonym: "nickel hydrogenase activity" NARROW [] +synonym: "nickel-iron hydrogenase activity" NARROW [] +synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] +synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] +xref: EC:1.12.7.2 +xref: MetaCyc:HYDROG-RXN +xref: RHEA:17445 +xref: UM-BBD_enzymeID:e0418 +is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor + +[Term] +id: GO:0008902 +name: hydroxymethylpyrimidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+)." [EC:2.7.1.49, RHEA:23096] +synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" RELATED [EC:2.7.1.49] +synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" RELATED [EC:2.7.1.49] +xref: EC:2.7.1.49 +xref: KEGG_REACTION:R03471 +xref: MetaCyc:OHMETPYRKIN-RXN +xref: RHEA:23096 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008903 +name: hydroxypyruvate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11952] +synonym: "hydroxypyruvate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.22] +synonym: "hydroxypyruvate ketol-isomerase activity" RELATED [EC:5.3.1.22] +xref: EC:5.3.1.22 +xref: KEGG_REACTION:R01394 +xref: MetaCyc:RXN0-305 +xref: RHEA:11952 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0008904 +name: hygromycin-B 7''-O-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+)." [EC:2.7.1.119, RHEA:23388] +synonym: "APH(7'') activity" RELATED [EC:2.7.1.119] +synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" RELATED [EC:2.7.1.119] +synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] +synonym: "hygromycin B kinase activity" BROAD [] +synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119] +synonym: "hygromycin-B kinase activity" BROAD [] +xref: EC:2.7.1.119 +xref: KEGG_REACTION:R03770 +xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN +xref: RHEA:23388 +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0008905 +name: mannose-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0008906 +name: inosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] +synonym: "ATP:inosine 5'-phosphotransferase activity" RELATED [EC:2.7.1.73] +synonym: "inosine kinase (phosphorylating)" RELATED [EC:2.7.1.73] +synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] +xref: EC:2.7.1.73 +xref: MetaCyc:INOSINEKIN-RXN +xref: RHEA:21140 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008907 +name: integrase activity +namespace: molecular_function +def: "Catalysis of the integration of one DNA segment into another." [GOC:mah] +subset: goslim_pir +xref: Reactome:R-HSA-164523 "Transesterification to connect viral DNA 3' ends to host DNA 5' ends" +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0008908 +name: isochorismatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11112] +synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" RELATED [EC:3.3.2.1] +synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" RELATED [EC:3.3.2.1] +synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" RELATED [EC:3.3.2.1] +synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" RELATED [EC:3.3.2.1] +synonym: "isochorismate pyruvate-hydrolase activity" RELATED [EC:3.3.2.1] +xref: EC:3.3.2.1 +xref: KEGG_REACTION:R03037 +xref: MetaCyc:ISOCHORMAT-RXN +xref: RHEA:11112 +is_a: GO:0004463 ! leukotriene-A4 hydrolase activity + +[Term] +id: GO:0008909 +name: isochorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18985] +comment: Note that this function was formerly EC:5.4.99.6. +synonym: "isochorismate hydroxymutase activity" RELATED [EC:5.4.4.2] +synonym: "isochorismate mutase activity" EXACT [] +synonym: "isochorismate synthetase activity" RELATED [EC:5.4.4.2] +xref: EC:5.4.4.2 +xref: KEGG_REACTION:R01717 +xref: MetaCyc:ISOCHORSYN-RXN +xref: RHEA:18985 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0008910 +name: kanamycin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256] +synonym: "aminoglycoside 3'-phosphotransferase activity" BROAD [EC:2.7.1.95] +synonym: "APH(3') activity" BROAD [EC:2.7.1.95] +synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" RELATED [EC:2.7.1.95] +synonym: "kanamycin kinase (phosphorylating)" RELATED [EC:2.7.1.95] +synonym: "neomycin phosphotransferase activity" RELATED [EC:2.7.1.95] +synonym: "neomycin-kanamycin phosphotransferase activity" RELATED [EC:2.7.1.95] +xref: EC:2.7.1.95 +xref: KEGG_REACTION:R01888 +xref: MetaCyc:KANAMYCIN-KINASE-RXN +xref: RHEA:24256 +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0008911 +name: lactaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] +synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.22] +synonym: "L-lactaldehyde:NAD oxidoreductase activity" RELATED [EC:1.2.1.22] +synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" RELATED [EC:1.2.1.22] +xref: EC:1.2.1.22 +xref: MetaCyc:LACTALDDEHYDROG-RXN +xref: RHEA:14277 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0008912 +name: lactaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77] +synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77] +synonym: "lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77] +synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77] +synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" RELATED [EC:1.1.1.77] +xref: EC:1.1.1.77 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008913 +name: lauroyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732] +synonym: "lauroyl transferase activity" EXACT [] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0008914 +name: leucyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] +synonym: "L-leucyl-tRNA:protein leucyltransferase activity" RELATED [EC:2.3.2.6] +synonym: "L/F transferase activity" RELATED [EC:2.3.2.6] +synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" RELATED [EC:2.3.2.6] +synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" RELATED [EC:2.3.2.6] +synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" RELATED [EC:2.3.2.6] +synonym: "leucyl-tRNA--protein transferase activity" RELATED [EC:2.3.2.6] +synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" RELATED [EC:2.3.2.6] +xref: EC:2.3.2.6 +xref: MetaCyc:LEUCYLTRANSFERASE-RXN +xref: RHEA:12340 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0008915 +name: lipid-A-disaccharide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP." [EC:2.4.1.182, RHEA:22668] +synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" RELATED [EC:2.4.1.182] +xref: EC:2.4.1.182 +xref: KEGG_REACTION:R04606 +xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN +xref: RHEA:22668 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008917 +name: lipopolysaccharide N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr] +synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.56] +synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.56] +synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.56] +xref: EC:2.4.1.56 +xref: MetaCyc:2.4.1.56-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0008918 +name: lipopolysaccharide 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr] +synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] +synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] +synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" RELATED [EC:2.4.1.44] +synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" RELATED [EC:2.4.1.44] +xref: EC:2.4.1.44 +xref: MetaCyc:2.4.1.44-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008919 +name: lipopolysaccharide glucosyltransferase I activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr] +synonym: "lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58] +synonym: "LPS glucosyltransferase I activity" EXACT [] +synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58] +synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58] +synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] +synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] +synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.58] +xref: EC:2.4.1.58 +xref: MetaCyc:2.4.1.58-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0008920 +name: lipopolysaccharide heptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127] +synonym: "LPS heptosyltransferase activity" EXACT [] +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0008921 +name: lipopolysaccharide-1,6-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] +synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0008922 +name: long-chain fatty acid [acyl-carrier-protein] ligase activity +namespace: molecular_function +alt_id: GO:0010300 +def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22." [EC:6.2.1.20] +synonym: "acyl-[acyl-carrier-protein] synthetase activity" RELATED [EC:6.2.1.20] +synonym: "acyl-ACP synthetase activity" EXACT [] +synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] +synonym: "acyl-acyl-carrier-protein synthetase activity" RELATED [EC:6.2.1.20] +synonym: "acyl-acyl-carrier-proteinsynthetase activity" RELATED [EC:6.2.1.20] +synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] +synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" RELATED [EC:6.2.1.20] +synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" RELATED [EC:6.2.1.20] +synonym: "stearoyl-ACP synthetase activity" RELATED [EC:6.2.1.20] +xref: EC:6.2.1.20 +xref: KEGG_REACTION:R07325 +xref: MetaCyc:ACYLACPSYNTH-RXN +xref: RHEA:45588 +is_a: GO:0015645 ! fatty acid ligase activity + +[Term] +id: GO:0008923 +name: lysine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2)." [EC:4.1.1.18, RHEA:22352] +synonym: "L-lysine carboxy-lyase (cadaverine-forming)" RELATED [EC:4.1.1.18] +synonym: "L-lysine carboxy-lyase activity" RELATED [EC:4.1.1.18] +xref: EC:4.1.1.18 +xref: KEGG_REACTION:R00462 +xref: MetaCyc:LYSDECARBOX-RXN +xref: MetaCyc:PWY0-461 +xref: RHEA:22352 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008924 +name: malate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [PMID:234747, RHEA:46012] +synonym: "(S)-malate:(quinone) oxidoreductase activity" RELATED [EC:1.1.5.4] +synonym: "(S)-malate:quinone oxidoreductase activity" RELATED [EC:1.1.5.4] +synonym: "FAD-dependent malate dehydrogenase activity" RELATED [EC:1.1.5.4] +synonym: "MQO activity" BROAD [EC:1.1.5.4] +xref: EC:1.1.5.4 +xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN +xref: RHEA:46012 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0008925 +name: maltose O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] +synonym: "acetyl-CoA:maltose O-acetyltransferase activity" RELATED [EC:2.3.1.79] +synonym: "maltose transacetylase activity" RELATED [EC:2.3.1.79] +xref: EC:2.3.1.79 +xref: MetaCyc:MALTACETYLTRAN-RXN +xref: RHEA:10456 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0008926 +name: mannitol-1-phosphate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] +xref: EC:1.1.1.17 +xref: MetaCyc:MANNPDEHYDROG-RXN +xref: RHEA:19661 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008927 +name: mannonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20097] +synonym: "altronate hydrolase activity" RELATED [EC:4.2.1.8] +synonym: "altronic hydro-lyase activity" RELATED [EC:4.2.1.8] +synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.2.1.8] +synonym: "D-mannonate hydro-lyase activity" RELATED [EC:4.2.1.8] +synonym: "D-mannonate hydrolyase activity" RELATED [EC:4.2.1.8] +synonym: "mannonate hydrolyase activity" RELATED [EC:4.2.1.8] +synonym: "mannonic hydrolase activity" RELATED [EC:4.2.1.8] +xref: EC:4.2.1.8 +xref: KEGG_REACTION:R05606 +xref: MetaCyc:MANNONDEHYDRAT-RXN +xref: RHEA:20097 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0008928 +name: mannose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate." [EC:2.7.7.22, RHEA:12905] +synonym: "GDP mannose phosphorylase activity" RELATED [EC:2.7.7.22] +synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.22] +synonym: "GDP-mannose phosphorylase activity" RELATED [EC:2.7.7.22] +synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] +synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.22] +synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.22] +synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.22] +synonym: "guanosine diphosphomannose phosphorylase activity" RELATED [EC:2.7.7.22] +synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" RELATED [EC:2.7.7.22] +synonym: "mannose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.22] +xref: EC:2.7.7.22 +xref: KEGG_REACTION:R00883 +xref: MetaCyc:MANNPGUANYLTRANGDP-RXN +xref: RHEA:12905 +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0008929 +name: methylglyoxal synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17937] +synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" RELATED [EC:4.2.3.3] +synonym: "glycerone-phosphate phospho-lyase activity" RELATED [EC:4.2.3.3] +synonym: "methylglyoxal synthetase activity" RELATED [EC:4.2.3.3] +xref: EC:4.2.3.3 +xref: KEGG_REACTION:R01016 +xref: MetaCyc:METHGLYSYN-RXN +xref: RHEA:17937 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0008930 +name: methylthioadenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] +synonym: "5'-methylthioadenosine nucleosidase activity" RELATED [EC:3.2.2.16] +synonym: "MeSAdo nucleosidase activity" RELATED [EC:3.2.2.16] +synonym: "methylthioadenosine methylthioribohydrolase activity" RELATED [EC:3.2.2.16] +synonym: "MTA nucleosidase activity" RELATED [EC:3.2.2.16] +synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" RELATED [EC:3.2.2.16] +xref: EC:3.2.2.16 +xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN +xref: RHEA:13617 +is_a: GO:0008477 ! purine nucleosidase activity + +[Term] +id: GO:0008931 +name: obsolete murein DD-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "murein DD-endopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008932 +name: lytic endotransglycosylase activity +namespace: molecular_function +def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] +synonym: "murein lytic endotransglycosylase E activity" NARROW [] +xref: EC:2.4.99.- +is_a: GO:0008933 ! lytic transglycosylase activity + +[Term] +id: GO:0008933 +name: lytic transglycosylase activity +namespace: molecular_function +def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424, PMID:22748813] +synonym: "murein transglycosylase B activity" NARROW [] +synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] +xref: EC:3.2.1.- +is_a: GO:0016757 ! glycosyltransferase activity +is_a: GO:0061783 ! peptidoglycan muralytic activity + +[Term] +id: GO:0008934 +name: inositol monophosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] +synonym: "inositol 1-phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] +synonym: "L-myo-inositol-1-phosphate phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol 1-phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD [] +synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25] +synonym: "myo-inositol-1-phosphatase activity" RELATED [EC:3.1.3.25] +xref: EC:3.1.3.25 +xref: MetaCyc:RXN0-5408 +xref: Reactome:R-HSA-1855154 "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol" +xref: RHEA:27670 +is_a: GO:0052834 ! inositol monophosphate phosphatase activity + +[Term] +id: GO:0008935 +name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O." [RHEA:26562] +synonym: "DHNA synthetase activity" RELATED [EC:4.1.3.36] +synonym: "dihydroxynaphthoate synthase activity" RELATED [] +synonym: "dihydroxynaphthoic acid synthetase activity" RELATED [EC:4.1.3.36] +synonym: "naphthoate synthase activity" RELATED [EC:4.1.3.36] +synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" RELATED [EC:4.1.3.36] +xref: EC:4.1.3.36 +xref: KEGG_REACTION:R04150 +xref: MetaCyc:NAPHTHOATE-SYN-RXN +xref: RHEA:26562 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0008936 +name: nicotinamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] +synonym: "NAMase activity" RELATED [EC:3.5.1.19] +synonym: "nicotinamide amidase activity" RELATED [EC:3.5.1.19] +synonym: "nicotinamide amidohydrolase activity" RELATED [EC:3.5.1.19] +synonym: "nicotinamide deaminase activity" RELATED [EC:3.5.1.19] +synonym: "nicotine deamidase activity" RELATED [EC:3.5.1.19] +synonym: "YNDase activity" RELATED [EC:3.5.1.19] +xref: EC:3.5.1.19 +xref: MetaCyc:NICOTINAMID-RXN +xref: RHEA:14545 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008937 +name: ferredoxin-NAD(P) reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [GOC:curators] +synonym: "ferredoxin reductase activity" BROAD [] +is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor + +[Term] +id: GO:0008938 +name: nicotinate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20241] +synonym: "furanocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.7] +synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" RELATED [EC:2.1.1.7] +xref: EC:2.1.1.7 +xref: KEGG_REACTION:R01721 +xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN +xref: RHEA:20241 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0008939 +name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate." [EC:2.4.2.21, RHEA:11196] +synonym: "CobT" RELATED [EC:2.4.2.21] +synonym: "N(1)-alpha-phosphoribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "N1-alpha-phosphoribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.21] +synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" RELATED [EC:2.4.2.21] +xref: EC:2.4.2.21 +xref: KEGG_REACTION:R04148 +xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN +xref: RHEA:11196 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0008940 +name: nitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4] +synonym: "nitrate reductase (acceptor)" RELATED [EC:1.7.99.4] +synonym: "nitrite:(acceptor) oxidoreductase" RELATED [EC:1.7.99.4] +synonym: "nitrite:acceptor oxidoreductase" RELATED [EC:1.7.99.4] +synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] +xref: EC:1.7.99.4 +xref: MetaCyc:NITRATREDUCT-RXN +xref: RHEA:21068 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0008941 +name: nitric oxide dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [EC:1.14.12.17] +synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.12.17] +synonym: "NOD activity" RELATED [EC:1.14.12.17] +xref: EC:1.14.12.17 +xref: MetaCyc:R621-RXN +xref: Reactome:R-HSA-1222723 "Nitric oxide is oxidized to nitrate" +xref: Reactome:R-HSA-5340226 "CYGB dioxygenates NO" +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0008942 +name: nitrite reductase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4, PMID:31961593] +comment: Note that this function was formerly EC:1.6.6.4. +synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.4] +synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] +synonym: "NAD(P)H2:nitrite oxidoreductase activity" RELATED [EC:1.7.1.4] +synonym: "NAD(P)H:nitrite oxidoreductase activity" RELATED [EC:1.7.1.4] +synonym: "NADH-nitrite oxidoreductase activity" RELATED [EC:1.7.1.4] +synonym: "NADPH-nitrite reductase activity" RELATED [EC:1.7.1.4] +synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" RELATED [EC:1.7.1.4] +synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] +xref: EC:1.7.1.4 +xref: KEGG_REACTION:R00787 +xref: KEGG_REACTION:R00789 +xref: MetaCyc:NITRITREDUCT-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor +is_a: GO:0098809 ! nitrite reductase activity + +[Term] +id: GO:0008943 +name: obsolete glyceraldehyde-3-phosphate dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] +comment: This term was made obsolete because it is a grouping term based on similar names. +synonym: "glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +is_obsolete: true +consider: GO:0004365 +consider: GO:0008886 +consider: GO:0043878 +consider: GO:0047100 + +[Term] +id: GO:0008944 +name: obsolete oligopeptidase A activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "68000-M signalpeptide hydrolase activity" RELATED [] +synonym: "oligopeptidase A activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008945 +name: obsolete oligopeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "Escherichia coli alkaline proteinase II" RELATED [] +synonym: "oligopeptidase B activity" EXACT [] +synonym: "protease II activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008946 +name: oligonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] +comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. +xref: EC:3.1.13.3 +xref: MetaCyc:3.1.13.3-RXN +is_a: GO:0004518 ! nuclease activity + +[Term] +id: GO:0008947 +name: obsolete omptin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "omptin activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008948 +name: oxaloacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.112] +synonym: "oxalacetic acid decarboxylase activity" EXACT [] +synonym: "oxalate beta-decarboxylase activity" RELATED [EC:4.1.1.112] +synonym: "oxaloacetate beta-decarboxylase activity" RELATED [EC:4.1.1.112] +synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [] +synonym: "oxaloacetate carboxy-lyase activity" RELATED [EC:4.1.1.112] +xref: EC:1.1.1.38 +xref: EC:1.1.1.40 +xref: EC:4.1.1.112 +xref: KEGG_REACTION:R00217 +xref: MetaCyc:OXALODECARB-RXN +xref: Reactome:R-HSA-9012016 "FAHD1:Zn2+ dimer hydrolyses OA to PYR" +xref: RHEA:15641 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008949 +name: oxalyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19333] +synonym: "oxalyl coenzyme A decarboxylase activity" RELATED [EC:4.1.1.8] +synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" RELATED [EC:4.1.1.8] +synonym: "oxalyl-CoA carboxy-lyase activity" RELATED [EC:4.1.1.8] +xref: EC:4.1.1.8 +xref: KEGG_REACTION:R01908 +xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN +xref: RHEA:19333 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0008950 +name: obsolete p-aminobenzoate synthetase +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:krc] +comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. +synonym: "p-aminobenzoate synthetase" EXACT [] +is_obsolete: true +consider: GO:0008696 +consider: GO:0046820 + +[Term] +id: GO:0008951 +name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN] +synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] +xref: MetaCyc:PALMITOTRANS-RXN +xref: RHEA:44012 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0008953 +name: penicillin amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] +synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" RELATED [EC:3.5.1.11] +synonym: "ampicillin acylase activity" RELATED [EC:3.5.1.11] +synonym: "benzylpenicillin acylase activity" RELATED [EC:3.5.1.11] +synonym: "novozym 217" RELATED [EC:3.5.1.11] +synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] +synonym: "penicillin acylase activity" RELATED [EC:3.5.1.11] +synonym: "penicillin amidohydrolase activity" RELATED [EC:3.5.1.11] +synonym: "semacylase activity" RELATED [EC:3.5.1.11] +xref: EC:3.5.1.11 +xref: MetaCyc:PENICILLIN-AMIDASE-RXN +xref: RHEA:18693 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0008954 +name: obsolete peptidoglycan synthetase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities. +synonym: "peptidoglycan synthetase activity" EXACT [] +is_obsolete: true +consider: GO:0008955 +consider: GO:0071972 + +[Term] +id: GO:0008955 +name: peptidoglycan glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] +synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.129] +synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] +synonym: "peptidoglycan TGase activity" RELATED [EC:2.4.1.129] +synonym: "peptidoglycan transglycosylase activity" RELATED [EC:2.4.1.129] +synonym: "PG-II activity" RELATED [EC:2.4.1.129] +synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" RELATED [EC:2.4.1.129] +xref: EC:2.4.1.129 +xref: MetaCyc:RXN0-5405 +xref: RHEA:23708 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0008956 +name: obsolete peptidyl-dipeptidase Dcp activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] +comment: This term was made obsolete because it represents a gene product. +synonym: "dipeptidyl carboxypeptidase (Dcp)" RELATED [EC:3.4.15.5] +synonym: "dipeptidyl carboxypeptidase activity" RELATED [EC:3.4.15.5] +synonym: "peptidyl-dipeptidase Dcp activity" EXACT [] +xref: EC:3.4.15.5 +xref: MetaCyc:3.4.15.5-RXN +is_obsolete: true +consider: GO:0008235 +consider: GO:0008241 + +[Term] +id: GO:0008957 +name: phenylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] +synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.39] +xref: EC:1.2.1.39 +xref: MetaCyc:PHENDEHYD-RXN +xref: RHEA:21392 +xref: UM-BBD_reactionID:r0035 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0008959 +name: phosphate acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] +synonym: "acetyl-CoA:phosphate acetyltransferase activity" RELATED [EC:2.3.1.8] +synonym: "phosphoacylase activity" RELATED [EC:2.3.1.8] +synonym: "phosphotransacetylase activity" RELATED [EC:2.3.1.8] +synonym: "PTA" RELATED [EC:2.3.1.8] +xref: EC:2.3.1.8 +xref: MetaCyc:PHOSACETYLTRANS-RXN +xref: RHEA:19521 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0008960 +name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] +synonym: "oligosaccharide glycerophosphotransferase activity" RELATED [EC:2.7.8.20] +synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" RELATED [EC:2.7.8.20] +synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] +synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] +xref: EC:2.7.8.20 +xref: MetaCyc:PGLYCEROLTRANSI-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008961 +name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048, RHEA:56712] +xref: EC:2.5.1.145 +xref: RHEA:56712 +is_a: GO:0016757 ! glycosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0008962 +name: phosphatidylglycerophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [PMID:4292860] +synonym: "PGP phosphatase activity" RELATED [EC:3.1.3.27] +synonym: "phosphatidylglycerol phosphatase activity" RELATED [EC:3.1.3.27] +synonym: "phosphatidylglycerol phosphate phosphatase activity" RELATED [EC:3.1.3.27] +synonym: "phosphatidylglycerophosphate phosphohydrolase activity" RELATED [EC:3.1.3.27] +xref: EC:3.1.3.27 +xref: MetaCyc:PGPPHOSPHA-RXN +xref: Reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG" +xref: RHEA:16725 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008963 +name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] +comment: Note that EC classifies all three 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under EC:2.7.8.13. +subset: goslim_chembl +synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] +synonym: "phospho-MurNAc-pentapeptide transferase activity" RELATED [EC:2.7.8.13] +synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" RELATED [EC:2.7.8.13] +synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" RELATED [EC:2.7.8.13] +synonym: "phosphoacetylmuramoylpentapeptide translocase activity" RELATED [EC:2.7.8.13] +synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" RELATED [EC:2.7.8.13] +synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" RELATED [EC:2.7.8.13] +xref: EC:2.7.8.13 +xref: MetaCyc:RXN-8975 +xref: RHEA:21920 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0008964 +name: phosphoenolpyruvate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-." [EC:4.1.1.31] +synonym: "PEP carboxylase activity" RELATED [EC:4.1.1.31] +synonym: "PEPC" RELATED [EC:4.1.1.31] +synonym: "PEPCase activity" RELATED [EC:4.1.1.31] +synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.31] +synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" RELATED [EC:4.1.1.31] +synonym: "phosphoenolpyruvic carboxylase activity" RELATED [EC:4.1.1.31] +synonym: "phosphopyruvate (phosphate) carboxylase activity" RELATED [EC:4.1.1.31] +xref: EC:4.1.1.31 +xref: KEGG_REACTION:R00345 +xref: MetaCyc:PEPCARBOX-RXN +xref: RHEA:28370 +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0008965 +name: phosphoenolpyruvate-protein phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] +synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] +synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" RELATED [EC:2.7.3.9] +synonym: "phosphoenolpyruvate--protein phosphatase activity" RELATED [EC:2.7.3.9] +synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" RELATED [EC:2.7.3.9] +synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" RELATED [EC:2.7.3.9] +synonym: "phosphopyruvate--protein factor phosphotransferase activity" RELATED [EC:2.7.3.9] +synonym: "phosphopyruvate--protein phosphotransferase activity" RELATED [EC:2.7.3.9] +synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] +xref: EC:2.7.3.9 +xref: MetaCyc:2.7.3.9-RXN +xref: RHEA:23880 +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0008966 +name: phosphoglucosamine mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23424] +synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.10] +synonym: "D-glucosamine 1,6-phosphomutase activity" RELATED [EC:5.4.2.10] +xref: EC:5.4.2.10 +xref: KEGG_REACTION:R02060 +xref: MetaCyc:5.4.2.10-RXN +xref: RHEA:23424 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008967 +name: phosphoglycolate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14369] +synonym: "2-phosphoglycolate phosphatase activity" RELATED [EC:3.1.3.18] +synonym: "2-phosphoglycolate phosphohydrolase activity" RELATED [EC:3.1.3.18] +synonym: "P-glycolate phosphatase activity" RELATED [EC:3.1.3.18] +synonym: "phosphoglycolate hydrolase activity" RELATED [EC:3.1.3.18] +synonym: "phosphoglycollate phosphatase activity" RELATED [EC:3.1.3.18] +xref: EC:3.1.3.18 +xref: KEGG_REACTION:R01334 +xref: MetaCyc:GPH-RXN +xref: RHEA:14369 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0008968 +name: D-sedoheptulose 7-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] +synonym: "phosphoheptose isomerase activity" EXACT [] +xref: MetaCyc:RXN0-4301 +xref: RHEA:27489 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008970 +name: phospholipase A1 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] +subset: goslim_chembl +synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [] +xref: EC:3.1.1.32 +xref: MetaCyc:PHOSPHOLIPASE-A1-RXN +xref: Reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C" +xref: Reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]" +xref: Reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)" +xref: Reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]" +xref: Reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C" +xref: Reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]" +xref: Reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]" +xref: Reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC" +xref: RHEA:18689 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0008972 +name: phosphomethylpyrimidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] +synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" RELATED [EC:2.7.4.7] +synonym: "hydroxymethylpyrimidine phosphokinase activity" RELATED [EC:2.7.4.7] +xref: EC:2.7.4.7 +xref: MetaCyc:PYRIMSYN3-RXN +xref: RHEA:19893 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0008973 +name: phosphopentomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] +synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" RELATED [EC:5.4.2.7] +synonym: "alpha-D-ribose 1,5-phosphomutase activity" RELATED [EC:5.4.2.7] +synonym: "D-ribose 1,5-phosphomutase activity" RELATED [EC:5.4.2.7] +synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] +synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] +synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] +synonym: "phosphoribomutase activity" RELATED [EC:5.4.2.7] +xref: EC:5.4.2.7 +xref: MetaCyc:PPENTOMUT-RXN +xref: Reactome:R-HSA-6787329 "PGM2:Mg2+ isomerises R1P to R5P" +xref: Reactome:R-HSA-8982667 "PGM2:Mg2+ isomerises dR1P to dR5P" +xref: RHEA:18793 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0008974 +name: phosphoribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19365] +synonym: "5-phosphoribulose kinase activity" RELATED [EC:2.7.1.19] +synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.19] +synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] +synonym: "phosphoribulokinase (phosphorylating)" RELATED [EC:2.7.1.19] +synonym: "PKK" RELATED [EC:2.7.1.19] +synonym: "PRK" RELATED [EC:2.7.1.19] +synonym: "PRuK" RELATED [EC:2.7.1.19] +synonym: "ribulose phosphate kinase activity" RELATED [EC:2.7.1.19] +synonym: "ribulose-5-phosphate kinase activity" RELATED [EC:2.7.1.19] +xref: EC:2.7.1.19 +xref: KEGG_REACTION:R01523 +xref: MetaCyc:PHOSPHORIBULOKINASE-RXN +xref: RHEA:19365 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0008975 +name: obsolete pitrilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "Escherichia coli metalloproteinase Pi" RELATED [] +synonym: "Escherichia coli protease III" RELATED [] +synonym: "pitrilysin activity" EXACT [] +synonym: "protease III activity" RELATED [] +synonym: "protease Pi activity" RELATED [] +synonym: "proteinase Pi" RELATED [] +synonym: "PTR" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0008976 +name: polyphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] +synonym: "ATP-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.1] +synonym: "ATP:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.1] +synonym: "polyphosphate polymerase activity" EXACT [] +synonym: "polyphosphoric acid kinase activity" RELATED [EC:2.7.4.1] +xref: EC:2.7.4.1 +xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN +xref: RHEA:19573 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0008977 +name: prephenate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." [EC:1.3.1.12, RHEA:13869] +synonym: "chorismate mutase--prephenate dehydrogenase activity" RELATED [EC:1.3.1.12] +synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] +synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.12] +xref: EC:1.3.1.12 +xref: KEGG_REACTION:R01728 +xref: MetaCyc:PREPHENATEDEHYDROG-RXN +xref: RHEA:13869 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0008978 +name: obsolete prepilin peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] +comment: This term was made obsolete because it represents a gene product. +synonym: "prepilin peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0008979 +name: prophage integrase activity +namespace: molecular_function +def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA." [GOC:jl] +synonym: "integrase activity involved in establishment of integrated proviral latency" EXACT [] +is_a: GO:0008907 ! integrase activity +is_a: GO:0009009 ! site-specific recombinase activity + +[Term] +id: GO:0008980 +name: propionate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15] +synonym: "ATP:propanoate phosphotransferase activity" EXACT [] +synonym: "PduW" RELATED [] +synonym: "propanoate kinase activity" EXACT [] +synonym: "TdcD" RELATED [] +xref: EC:2.7.2.15 +xref: RHEA:23148 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0008981 +name: obsolete protease IV activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "protease IV activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008982 +name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +namespace: molecular_function +alt_id: GO:0015455 +alt_id: GO:0015456 +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] +synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] +synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] +synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] +synonym: "gene glC proteins" RELATED [EC:2.7.1.69] +synonym: "group translocator activity" RELATED [EC:2.7.1.69] +synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] +synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] +synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] +synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" RELATED [EC:2.7.1.69] +synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" RELATED [EC:2.7.1.69] +synonym: "phosphoprotein factor-hexose phosophotransferase activity" RELATED [EC:2.7.1.69] +synonym: "phosphotransfer-driven group translocator" EXACT [] +synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" RELATED [EC:2.7.1.69] +synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] +synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] +synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" RELATED [EC:2.7.1.69] +synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" RELATED [EC:2.7.1.69] +synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" RELATED [EC:2.7.1.69] +synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" RELATED [EC:2.7.1.69] +synonym: "PTS permease activity" RELATED [EC:2.7.1.69] +synonym: "PTS transporter" RELATED [EC:2.7.1.69] +synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] +synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] +xref: EC:2.7.1.69 +xref: MetaCyc:2.7.1.69-RXN +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0008983 +name: protein-glutamate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] +synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] +synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] +synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] +synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] +synonym: "protein carboxyl-methylase activity" RELATED [EC:2.1.1.80] +synonym: "protein carboxyl-O-methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] +synonym: "protein carboxymethylase activity" RELATED [EC:2.1.1.80] +synonym: "protein carboxymethyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "protein methylase II" RELATED [EC:2.1.1.80] +synonym: "protein O-methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "protein(aspartate)methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "protein(carboxyl)methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" RELATED [EC:2.1.1.80] +synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" RELATED [EC:2.1.1.80] +xref: EC:2.1.1.80 +xref: MetaCyc:CHER-RXN +xref: RESID:AA0072 +xref: RHEA:24452 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity + +[Term] +id: GO:0008984 +name: protein-glutamate methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] +synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] +synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] +synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] +synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] +synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" RELATED [EC:3.1.1.61] +synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" RELATED [EC:3.1.1.61] +xref: EC:3.1.1.61 +xref: MetaCyc:MCPMETEST-RXN +xref: RESID:AA0072 +xref: RHEA:23236 +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0008985 +name: obsolete pyruvate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] +comment: This term was made obsolete because the EC activity it represents, EC:1.2.2.2, has been deleted. +synonym: "pyruvate dehydrogenase (cytochrome) activity" EXACT [] +synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.2] +synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.2.2] +synonym: "pyruvic (cytochrome b1) dehydrogenase activity" RELATED [EC:1.2.2.2] +is_obsolete: true +replaced_by: GO:0052737 + +[Term] +id: GO:0008986 +name: pyruvate, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate." [EC:2.7.9.2, RHEA:11364] +synonym: "ATP:pyruvate, water phosphotransferase activity" RELATED [EC:2.7.9.2] +synonym: "PEP synthase activity" EXACT [] +synonym: "PEP synthetase activity" RELATED [EC:2.7.9.2] +synonym: "phoephoenolpyruvate synthetase activity" RELATED [EC:2.7.9.2] +synonym: "phosphoenolpyruvate synthase activity" RELATED [EC:2.7.9.2] +synonym: "phosphoenolpyruvic synthase activity" RELATED [EC:2.7.9.2] +synonym: "phosphopyruvate synthetase activity" RELATED [EC:2.7.9.2] +synonym: "pyruvate,water dikinase activity" RELATED [EC:2.7.9.2] +synonym: "pyruvate-water dikinase (phosphorylating)" RELATED [EC:2.7.9.2] +synonym: "water pyruvate dikinase activity" EXACT [] +xref: EC:2.7.9.2 +xref: KEGG_REACTION:R00199 +xref: MetaCyc:PEPSYNTH-RXN +xref: RHEA:11364 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0008987 +name: quinolinate synthetase A activity +namespace: molecular_function +def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] +xref: MetaCyc:QUINOLINATE-SYNTHA-RXN +xref: RHEA:25888 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0008988 +name: rRNA (adenine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] +synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] +synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] +synonym: "ribonucleic acid-adenine (N(6)) methylase activity" RELATED [EC:2.1.1.48] +synonym: "ribonucleic acid-adenine (N6) methylase activity" RELATED [EC:2.1.1.48] +synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" RELATED [EC:2.1.1.48] +synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" RELATED [EC:2.1.1.48] +synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" RELATED [EC:2.1.1.48] +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0008989 +name: rRNA (guanine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [GOC:curators] +synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" RELATED [EC:2.1.1.51] +xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008990 +name: rRNA (guanine-N2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] +synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" RELATED [EC:2.1.1.52] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" RELATED [EC:2.1.1.52] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" RELATED [EC:2.1.1.52] +xref: EC:2.1.1.52 +xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0008991 +name: obsolete serine-type signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +synonym: "serine-type signal peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008992 +name: obsolete repressor LexA activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "LexA repressor" RELATED [] +synonym: "repressor lexA" RELATED [] +synonym: "repressor LexA activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0008993 +name: rhamnulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] +synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" RELATED [EC:2.7.1.5] +synonym: "L-rhamnulokinase activity" RELATED [EC:2.7.1.5] +synonym: "L-rhamnulose kinase activity" RELATED [EC:2.7.1.5] +synonym: "rhamnulokinase (phosphorylating)" RELATED [EC:2.7.1.5] +synonym: "rhamnulose kinase activity" RELATED [EC:2.7.1.5] +synonym: "RhuK" RELATED [EC:2.7.1.5] +xref: EC:2.7.1.5 +xref: MetaCyc:RHAMNULOKIN-RXN +xref: RHEA:20117 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0008994 +name: rhamnulose-1-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] +synonym: "L-rhamnulose 1-phosphate aldolase activity" RELATED [EC:4.1.2.19] +synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" RELATED [EC:4.1.2.19] +synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.19] +synonym: "L-rhamnulose-phosphate aldolase activity" RELATED [EC:4.1.2.19] +synonym: "rhamnulose phosphate aldolase activity" RELATED [EC:4.1.2.19] +xref: EC:4.1.2.19 +xref: MetaCyc:RHAMNULPALDOL-RXN +xref: RHEA:19689 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0008995 +name: ribonuclease E activity +namespace: molecular_function +def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] +xref: MetaCyc:3.1.26.12-RXN +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008996 +name: ribonuclease G activity +namespace: molecular_function +def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008997 +name: ribonuclease R activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] +xref: EC:3.1.11.- +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0008998 +name: ribonucleoside-triphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] +synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" RELATED [EC:1.17.4.2] +synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" RELATED [EC:1.17.4.2] +synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] +xref: EC:1.17.4.2 +xref: MetaCyc:1.17.4.2-RXN +xref: RHEA:12701 +is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor + +[Term] +id: GO:0008999 +name: ribosomal protein S5-alanine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-alanyl-[ribosomal protein] = CoA + H+ + N-terminal N-alpha-acetyl-L-alanyl-[ribosomal protein]." [RHEA:43752] +synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" RELATED [] +synonym: "ribosomal protein S18 acetyltransferase activity" RELATED [] +synonym: "ribosomal-protein-alanine N-acetyltransferase activity" BROAD [] +xref: MetaCyc:2.3.1.128-RXN +xref: RHEA:16433 +is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity + +[Term] +id: GO:0009000 +name: selenocysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] +synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" RELATED [EC:4.4.1.16] +synonym: "selenocysteine beta-lyase activity" RELATED [EC:4.4.1.16] +synonym: "selenocysteine reductase activity" RELATED [EC:4.4.1.16] +xref: EC:4.4.1.16 +xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN +xref: Reactome:R-HSA-2408524 "Sec is reduced to H2Se by PXLP-K259-SCLY dimer" +xref: RHEA:11632 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0009001 +name: serine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24560] +synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" RELATED [EC:2.3.1.30] +synonym: "L-serine acetyltransferase activity" RELATED [EC:2.3.1.30] +synonym: "SATase activity" RELATED [EC:2.3.1.30] +synonym: "serine acetyltransferase activity" RELATED [EC:2.3.1.30] +synonym: "serine transacetylase activity" RELATED [EC:2.3.1.30] +xref: EC:2.3.1.30 +xref: KEGG_REACTION:R00586 +xref: MetaCyc:SERINE-O-ACETTRAN-RXN +xref: RHEA:24560 +is_a: GO:0016412 ! serine O-acyltransferase activity +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0009002 +name: serine-type D-Ala-D-Ala carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] +synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] +synonym: "D-alanyl carboxypeptidase activity" RELATED [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine carboxypeptidase activity" RELATED [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-carboxypeptidase activity" RELATED [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-cleaving peptidase activity" RELATED [EC:3.4.16.4] +synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" RELATED [EC:3.4.16.4] +synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] +synonym: "DD-peptidase activity" RELATED [EC:3.4.16.4] +synonym: "DD-transpeptidase activity" RELATED [EC:3.4.16.4] +xref: EC:3.4.16.4 +xref: MetaCyc:3.4.16.4-RXN +is_a: GO:0004185 ! serine-type carboxypeptidase activity + +[Term] +id: GO:0009003 +name: obsolete signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +synonym: "signal peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008233 + +[Term] +id: GO:0009004 +name: obsolete signal peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "bacterial leader peptidase 1" RELATED [] +synonym: "bacterial leader peptidase I activity" NARROW [] +synonym: "Escherichia coli leader peptidase" NARROW [] +synonym: "eukaryotic signal peptidase" NARROW [] +synonym: "eukaryotic signal proteinase" NARROW [] +synonym: "HOSP" RELATED [] +synonym: "leader peptidase activity" RELATED [] +synonym: "leader peptidase I" RELATED [] +synonym: "leader peptide hydrolase activity" RELATED [] +synonym: "leader proteinase activity" RELATED [] +synonym: "phage-procoat-leader peptidase activity" NARROW [] +synonym: "pilin leader peptidase" NARROW [] +synonym: "prokaryotic leader peptidase" NARROW [] +synonym: "prokaryotic signal peptidase" NARROW [] +synonym: "prokaryotic signal proteinase" NARROW [] +synonym: "propeptidase activity" RELATED [] +synonym: "PuIO prepilin peptidase" NARROW [] +synonym: "signal peptidase I activity" EXACT [] +synonym: "signal peptide hydrolase activity" RELATED [] +synonym: "signal proteinase activity" RELATED [] +synonym: "signalase activity" RELATED [] +synonym: "SPase I activity" RELATED [] +synonym: "SPC" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0009005 +name: obsolete signal peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] +comment: This term was made obsolete because it represents a gene product. +synonym: "leader peptidase II" RELATED [EC:3.4.23.36] +synonym: "lipoprotein signal peptidase activity" RELATED [EC:3.4.23.36] +synonym: "premurein leader proteinase activity" RELATED [EC:3.4.23.36] +synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] +synonym: "prolipoprotein signal peptidase activity" RELATED [EC:3.4.23.36] +synonym: "prolipoprotein-signal peptidase activity" RELATED [EC:3.4.23.36] +synonym: "signal peptidase II activity" EXACT [] +synonym: "SPase II activity" RELATED [EC:3.4.23.36] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0009006 +name: obsolete siroheme synthase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents three different molecular functions. +synonym: "sirohaem synthase activity" EXACT [] +synonym: "siroheme synthase activity" EXACT [] +is_obsolete: true +consider: GO:0004851 +consider: GO:0019354 +consider: GO:0043115 +consider: GO:0051266 + +[Term] +id: GO:0009007 +name: site-specific DNA-methyltransferase (adenine-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] +synonym: "DNA adenine methylase" BROAD [] +synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] +synonym: "modification methylase activity" RELATED [EC:2.1.1.72] +synonym: "N-6 adenine-specific DNA methylase activity" RELATED [EC:2.1.1.72] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] +xref: EC:2.1.1.72 +xref: MetaCyc:2.1.1.72-RXN +xref: RHEA:15197 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0009008 +name: DNA-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732, PMID:7862522] +synonym: "deoxyribonucleate methylase activity" EXACT [] +synonym: "deoxyribonucleate methyltransferase activity" EXACT [] +synonym: "deoxyribonucleic acid methylase activity" EXACT [] +synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [] +synonym: "deoxyribonucleic acid modification methylase activity" RELATED [] +synonym: "DNA methylase" BROAD [] +synonym: "DNA methyltransferase activity" EXACT [] +synonym: "DNA transmethylase activity" EXACT [] +synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] +xref: Reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes" +is_a: GO:0008168 ! methyltransferase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0009009 +name: site-specific recombinase activity +namespace: molecular_function +def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences." [GOC:elh, PMID:6286142] +comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. +subset: goslim_pir +synonym: "RecA-family recombinase activity" EXACT [] +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0009010 +name: sorbitol-6-phosphate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] +synonym: "D-glucitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140] +synonym: "D-sorbitol 6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140] +synonym: "D-sorbitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140] +synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.140] +synonym: "glucitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.140] +synonym: "ketosephosphate reductase activity" RELATED [EC:1.1.1.140] +synonym: "sorbitol-6-P-dehydrogenase activity" RELATED [EC:1.1.1.140] +xref: EC:1.1.1.140 +xref: MetaCyc:SORB6PDEHYDROG-RXN +xref: RHEA:19837 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009011 +name: starch synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] +synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [] +synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [] +synonym: "ADP-glucose starch synthase activity" RELATED [EC:2.4.1.21] +synonym: "ADP-glucose transglucosylase activity" EXACT [] +synonym: "ADP-glucose--starch glucosyltransferase activity" RELATED [EC:2.4.1.21] +synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "ADPG starch synthetase activity" EXACT [] +synonym: "ADPG-starch glucosyltransferase activity" EXACT [] +synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [] +synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "glycogen synthase activity" RELATED [EC:2.4.1.21] +synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] +synonym: "starch synthetase activity" EXACT [] +xref: EC:2.4.1.21 +xref: MetaCyc:GLYCOGENSYN-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0009012 +name: aminoglycoside 3''-adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+)." [EC:2.7.7.47, RHEA:20245] +synonym: "AAD (3'')" RELATED [EC:2.7.7.47] +synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] +synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] +xref: EC:2.7.7.47 +xref: KEGG_REACTION:R02226 +xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN +xref: RHEA:20245 +is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity + +[Term] +id: GO:0009013 +name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] +synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" RELATED [EC:1.2.1.16] +synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.16] +xref: EC:1.2.1.16 +xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN +xref: UM-BBD_reactionID:r0371 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009014 +name: succinyl-diaminopimelate desuccinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22608] +synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" RELATED [EC:3.5.1.18] +synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.18] +xref: EC:3.5.1.18 +xref: KEGG_REACTION:R02734 +xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN +xref: RHEA:22608 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009015 +name: N-succinylarginine dihydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+)." [EC:3.5.3.23, RHEA:19533] +synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" RELATED [EC:3.5.3.23] +synonym: "arginine succinylhydrolase activity" EXACT [] +synonym: "AruB" RELATED [] +synonym: "AstB" RELATED [] +synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] +synonym: "N2-succinylarginine dihydrolase activity" EXACT [] +synonym: "SADH" RELATED [] +synonym: "succinylarginine dihydrolase activity" EXACT [] +xref: EC:3.5.3.23 +xref: KEGG_REACTION:R04189 +xref: MetaCyc:SUCCARGDIHYDRO-RXN +xref: RHEA:19533 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0009016 +name: succinyldiaminopimelate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11960] +synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.17] +synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" RELATED [EC:2.6.1.17] +synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] +synonym: "succinyldiaminopimelate transferase activity" RELATED [EC:2.6.1.17] +xref: EC:2.6.1.17 +xref: KEGG_REACTION:R04475 +xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN +xref: RHEA:11960 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0009017 +name: succinylglutamate desuccinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15169] +synonym: "AstE" RELATED [] +synonym: "N-succinyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.96] +synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] +synonym: "SGDS" RELATED [] +xref: EC:3.5.1.96 +xref: KEGG_REACTION:R00411 +xref: MetaCyc:SUCCGLUDESUCC-RXN +xref: RHEA:15169 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009018 +name: sucrose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] +synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] +synonym: "sucrose glucosyltransferase activity" RELATED [EC:2.4.1.7] +synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.7] +xref: EC:2.4.1.7 +xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN +xref: RHEA:24048 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0009019 +name: tRNA (guanine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" RELATED [EC:2.1.1.31] +synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" RELATED [EC:2.1.1.31] +synonym: "transfer ribonucleate guanine 1-methyltransferase activity" RELATED [EC:2.1.1.31] +synonym: "tRNA guanine 1-methyltransferase activity" RELATED [EC:2.1.1.31] +xref: Reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)" +xref: Reactome:R-HSA-6786621 "TRMT10A methylates guanosine-9 in tRNA" +xref: Reactome:R-HSA-6787591 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9" +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity + +[Term] +id: GO:0009020 +name: tRNA (guanosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34, RHEA:20077] +synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA (Gm18) methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA (guanosine 2')-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA guanosine 2'-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA guanosine-2'-O-methyltransferase activity" RELATED [EC:2.1.1.34] +xref: EC:2.1.1.34 +xref: MetaCyc:2.1.1.34-RXN +xref: Reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)" +xref: RHEA:20077 +is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity +is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity + +[Term] +id: GO:0009022 +name: tRNA nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] +comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. +synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] +synonym: "ribonuclease PH activity" RELATED [EC:2.7.7.56] +synonym: "RNase PH activity" RELATED [EC:2.7.7.56] +synonym: "tRNA:phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.56] +xref: EC:2.7.7.56 +xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN +xref: RHEA:10628 +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0009023 +name: obsolete tRNA sulfurtransferase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] +synonym: "tRNA sulfurtransferase" EXACT [] +synonym: "tRNA sulphurtransferase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0034227 +consider: GO:0016783 + +[Term] +id: GO:0009024 +name: tagatose-6-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] +synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.144] +synonym: "phosphotagatokinase activity" RELATED [EC:2.7.1.144] +xref: EC:2.7.1.144 +xref: MetaCyc:TAGAKIN-RXN +xref: RHEA:12420 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009025 +name: tagatose-bisphosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22948] +synonym: "AgaY" RELATED [] +synonym: "AgaZ" RELATED [] +synonym: "D-tagatose-1,6-bisphosphate aldolase activity" RELATED [EC:4.1.2.40] +synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.40] +synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] +synonym: "KbaY" RELATED [] +synonym: "tagatose 1,6-diphosphate aldolase activity" RELATED [EC:4.1.2.40] +synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] +xref: EC:4.1.2.40 +xref: KEGG_REACTION:R01069 +xref: MetaCyc:TAGAALDOL-RXN +xref: RHEA:22948 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0009026 +name: tagaturonate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH." [EC:1.1.1.58, RHEA:17813] +synonym: "altronate dehydrogenase activity" RELATED [EC:1.1.1.58] +synonym: "altronate oxidoreductase activity" RELATED [EC:1.1.1.58] +synonym: "altronic oxidoreductase activity" RELATED [EC:1.1.1.58] +synonym: "D-altronate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.58] +synonym: "D-tagaturonate reductase activity" RELATED [EC:1.1.1.58] +synonym: "tagaturonate dehydrogenase activity" RELATED [EC:1.1.1.58] +synonym: "TagUAR" RELATED [EC:1.1.1.58] +xref: EC:1.1.1.58 +xref: KEGG_REACTION:R02555 +xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN +xref: RHEA:17813 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009027 +name: tartrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] +synonym: "mesotartrate dehydrogenase activity" RELATED [EC:1.1.1.93] +synonym: "tartrate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.93] +xref: EC:1.1.1.93 +xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN +xref: RHEA:15209 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009028 +name: tartronate-semialdehyde synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.47, RHEA:10136] +synonym: "glyoxalate carboligase activity" RELATED [EC:4.1.1.47] +synonym: "glyoxylate carbo-ligase activity" RELATED [EC:4.1.1.47] +synonym: "glyoxylate carboligase activity" RELATED [EC:4.1.1.47] +synonym: "glyoxylate carboxy-lyase (dimerizing)" RELATED [EC:4.1.1.47] +synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" RELATED [EC:4.1.1.47] +synonym: "glyoxylic carbo-ligase activity" RELATED [EC:4.1.1.47] +synonym: "hydroxymalonic semialdehyde carboxylase activity" RELATED [EC:4.1.1.47] +synonym: "tartronate semialdehyde carboxylase activity" RELATED [EC:4.1.1.47] +synonym: "tartronic semialdehyde carboxylase activity" RELATED [EC:4.1.1.47] +xref: EC:4.1.1.47 +xref: KEGG_REACTION:R00013 +xref: MetaCyc:GLYOCARBOLIG-RXN +xref: RHEA:10136 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0009029 +name: tetraacyldisaccharide 4'-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a)." [EC:2.7.1.130, RHEA:20700] +synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" RELATED [EC:2.7.1.130] +synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] +xref: EC:2.7.1.130 +xref: KEGG_REACTION:R04657 +xref: MetaCyc:TETRAACYLDISACC4KIN-RXN +xref: RHEA:20700 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009030 +name: thiamine-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate." [EC:2.7.4.16, RHEA:15913] +synonym: "ATP:thiamine-phosphate phosphotransferase activity" RELATED [EC:2.7.4.16] +synonym: "thiamin monophosphatase activity" RELATED [EC:2.7.4.16] +synonym: "thiamin monophosphokinase activity" RELATED [EC:2.7.4.16] +synonym: "thiamin phosphate kinase activity" EXACT [] +synonym: "thiamin-monophosphate kinase activity" RELATED [EC:2.7.4.16] +synonym: "thiamin-phosphate kinase activity" EXACT [] +synonym: "thiamine-monophosphate kinase activity" RELATED [EC:2.7.4.16] +xref: EC:2.7.4.16 +xref: KEGG_REACTION:R00617 +xref: MetaCyc:THI-P-KIN-RXN +xref: RHEA:15913 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0009032 +name: thymidine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [RHEA:16037] +synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] +synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" RELATED [] +synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" RELATED [] +synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" RELATED [] +xref: EC:2.4.2.4 +xref: MetaCyc:THYM-PHOSPH-RXN +xref: RHEA:16037 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0009033 +name: trimethylamine-N-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [RHEA:22024] +synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [] +synonym: "trimethylamine N-oxide reductase" EXACT [] +synonym: "trimethylamine oxidase activity" EXACT [] +synonym: "trimethylamine oxide reductase" EXACT [] +xref: MetaCyc:TMAOREDUCT-RXN +xref: RHEA:22024 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0009034 +name: tryptophanase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate." [RHEA:19553] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "L-tryptophan indole-lyase (deaminating) activity" RELATED [EC:4.1.99.1] +synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" RELATED [EC:4.1.99.1] +synonym: "L-tryptophan indole-lyase activity" RELATED [EC:4.1.99.1] +synonym: "L-tryptophanase activity" RELATED [EC:4.1.99.1] +synonym: "TNase activity" RELATED [EC:4.1.99.1] +synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] +synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] +xref: EC:4.1.99.1 +xref: KEGG_REACTION:R00673 +xref: MetaCyc:TRYPDEG-PWY +xref: MetaCyc:TRYPTOPHAN-RXN +xref: RHEA:19553 +xref: UniPathway:UPA00332 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0009035 +name: type I site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [PMID:15300241, PMID:15788748] +synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" RELATED [EC:3.1.21.3] +synonym: "ATP-dependent DNase activity" RELATED [EC:3.1.21.3] +synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" RELATED [EC:3.1.21.3] +synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" RELATED [EC:3.1.21.3] +synonym: "type I restriction enzyme activity" EXACT [] +xref: EC:3.1.21.3 +xref: MetaCyc:3.1.21.3-RXN +is_a: GO:0015616 ! DNA translocase activity +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0009036 +name: type II site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] +synonym: "type II restriction enzyme activity" EXACT [] +xref: EC:3.1.21.4 +xref: MetaCyc:3.1.21.4-RXN +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0009037 +name: tyrosine-based site-specific recombinase activity +namespace: molecular_function +def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] +synonym: "site-specific tyrosine recombinase activity" EXACT [] +synonym: "tyrosine recombinase" BROAD [] +is_a: GO:0008907 ! integrase activity +is_a: GO:0009009 ! site-specific recombinase activity + +[Term] +id: GO:0009038 +name: undecaprenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66, RHEA:23752] +synonym: "ATP:undecaprenol phosphotransferase activity" RELATED [EC:2.7.1.66] +synonym: "C55-isoprenoid alcohol kinase activity" RELATED [EC:2.7.1.66] +synonym: "C55-isoprenoid alcohol phosphokinase activity" RELATED [EC:2.7.1.66] +synonym: "C55-isoprenyl alcohol phosphokinase activity" RELATED [EC:2.7.1.66] +synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66] +synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66] +synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66] +synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] +synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66] +xref: EC:2.7.1.66 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0009039 +name: urease activity +namespace: molecular_function +def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5, RHEA:20557] +synonym: "urea amidohydrolase activity" RELATED [EC:3.5.1.5] +xref: EC:3.5.1.5 +xref: MetaCyc:UREASE-RXN +xref: RHEA:20557 +xref: UM-BBD_reactionID:r0120 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0009040 +name: ureidoglycolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+." [EC:1.1.1.154, PMID:23284870] +synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.154] +xref: EC:1.1.1.154 +xref: MetaCyc:R165-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0009041 +name: uridylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] +xref: EC:2.7.4.22 +is_a: GO:0050145 ! nucleoside monophosphate kinase activity + +[Term] +id: GO:0009042 +name: valine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22912] +synonym: "alanine--valine transaminase activity" RELATED [EC:2.6.1.66] +synonym: "alanine-oxoisovalerate aminotransferase activity" RELATED [EC:2.6.1.66] +synonym: "L-valine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.66] +synonym: "transaminase C activity" NARROW [EC:2.6.1.66] +synonym: "valine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.66] +synonym: "valine-pyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.66 +xref: KEGG_REACTION:R01215 +xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN +xref: RHEA:22912 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0009044 +name: xylan 1,4-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] +synonym: "1,4-beta-D-xylan xylohydrolase activity" RELATED [EC:3.2.1.37] +synonym: "beta-D-xylopyranosidase activity" RELATED [EC:3.2.1.37] +synonym: "beta-xylosidase activity" RELATED [EC:3.2.1.37] +synonym: "exo-1,4-beta-D-xylosidase activity" RELATED [EC:3.2.1.37] +synonym: "exo-1,4-beta-xylosidase activity" RELATED [EC:3.2.1.37] +synonym: "exo-1,4-xylosidase activity" RELATED [EC:3.2.1.37] +synonym: "xylobiase activity" RELATED [EC:3.2.1.37] +xref: EC:3.2.1.37 +xref: MetaCyc:3.2.1.37-RXN +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0009045 +name: xylose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] +synonym: "D-xylose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.5] +synonym: "D-xylose isomerase activity" RELATED [EC:5.3.1.5] +synonym: "D-xylose ketoisomerase activity" RELATED [EC:5.3.1.5] +synonym: "D-xylose ketol-isomerase activity" RELATED [EC:5.3.1.5] +xref: EC:5.3.1.5 +xref: MetaCyc:XYLISOM-RXN +xref: RHEA:22816 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0009046 +name: zinc D-Ala-D-Ala carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] +synonym: "D-alanyl-D-alanine hydrolase activity" RELATED [EC:3.4.17.14] +synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" RELATED [EC:3.4.17.14] +synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] +synonym: "DD-carboxypeptidase-transpeptidase activity" RELATED [EC:3.4.17.14] +synonym: "G enzyme" RELATED [EC:3.4.17.14] +synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] +synonym: "Zn2+ G peptidase activity" RELATED [EC:3.4.17.14] +xref: EC:3.4.17.14 +xref: MetaCyc:3.4.17.14-RXN +is_a: GO:0004181 ! metallocarboxypeptidase activity + +[Term] +id: GO:0009047 +name: dosage compensation by hyperactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mr, ISBN:0140512888, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system] +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0009048 +name: dosage compensation by inactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:mr, GOC:pr, ISBN:0140512888, PMID:11498577, PMID:20622855, Wikipedia:XY_sex-determination_system] +synonym: "Barr body formation" RELATED [] +synonym: "chromosome inactivation" BROAD [] +synonym: "X chromosome inactivation" EXACT [] +xref: Wikipedia:X-inactivation +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0009049 +name: obsolete aspartic-type signal peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] +comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. +synonym: "aspartic-type signal peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0009050 +name: glycopeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, a compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732] +synonym: "glycopeptide breakdown" EXACT [] +synonym: "glycopeptide catabolism" EXACT [] +synonym: "glycopeptide degradation" EXACT [] +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0009051 +name: pentose-phosphate shunt, oxidative branch +namespace: biological_process +def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY] +synonym: "oxidative branch, pentose pathway" EXACT [] +synonym: "oxidative pentose phosphate pathway" EXACT [] +synonym: "pentose phosphate pathway, oxidative branch" EXACT [] +synonym: "pentose phosphate shunt, oxidative branch" EXACT [] +synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] +xref: MetaCyc:OXIDATIVEPENT-PWY +is_a: GO:0006740 ! NADPH regeneration +is_a: GO:0051156 ! glucose 6-phosphate metabolic process +relationship: part_of GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0009052 +name: pentose-phosphate shunt, non-oxidative branch +namespace: biological_process +def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY] +synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] +synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] +synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] +xref: MetaCyc:NONOXIPENT-PWY +xref: MetaCyc:P21-PWY +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:1901135 ! carbohydrate derivative metabolic process +relationship: part_of GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0009055 +name: electron transfer activity +namespace: molecular_function +alt_id: GO:0009053 +alt_id: GO:0009054 +def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] +comment: Note that this term should only be be used for electron transfer that generates a transmembrane electrochemical gradient, e.g. components of the respiratory or photosynthetic electron transport chain. +subset: goslim_metagenomics +subset: goslim_pir +synonym: "electron acceptor activity" NARROW [] +synonym: "electron carrier" RELATED [] +synonym: "electron donor activity" NARROW [] +synonym: "electron transporter activity" RELATED [] +xref: Reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF" +xref: Reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0009056 +name: catabolic process +namespace: biological_process +alt_id: GO:0044243 +alt_id: GO:0044712 +def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_plant +synonym: "breakdown" EXACT [] +synonym: "catabolism" EXACT [] +synonym: "degradation" EXACT [] +synonym: "multicellular organismal catabolic process" NARROW [] +synonym: "single-organism catabolic process" RELATED [] +xref: Wikipedia:Catabolism +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0009057 +name: macromolecule catabolic process +namespace: biological_process +alt_id: GO:0043285 +alt_id: GO:0044266 +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] +subset: goslim_pir +synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "macromolecule breakdown" EXACT [] +synonym: "macromolecule catabolism" EXACT [] +synonym: "macromolecule degradation" EXACT [] +synonym: "multicellular organismal macromolecule catabolic process" NARROW [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0009058 +name: biosynthetic process +namespace: biological_process +alt_id: GO:0044274 +alt_id: GO:0044711 +def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_plant +synonym: "anabolism" EXACT [] +synonym: "biosynthesis" EXACT [] +synonym: "formation" BROAD [] +synonym: "multicellular organismal biosynthetic process" NARROW [] +synonym: "single-organism biosynthetic process" RELATED [] +synonym: "synthesis" EXACT [] +xref: Wikipedia:Anabolism +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0009059 +name: macromolecule biosynthetic process +namespace: biological_process +alt_id: GO:0043284 +def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] +subset: goslim_pir +synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "macromolecule anabolism" EXACT [] +synonym: "macromolecule biosynthesis" EXACT [] +synonym: "macromolecule formation" EXACT [] +synonym: "macromolecule synthesis" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0009060 +name: aerobic respiration +namespace: biological_process +def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] +xref: MetaCyc:PWY-3781 +xref: Wikipedia:Cellular_respiration#Aerobic_respiration +is_a: GO:0045333 ! cellular respiration + +[Term] +id: GO:0009061 +name: anaerobic respiration +namespace: biological_process +def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] +xref: MetaCyc:ANARESP1-PWY +xref: Wikipedia:Anaerobic_respiration +xref: Wikipedia:Cellular_respiration#Anaerobic_respiration +is_a: GO:0045333 ! cellular respiration + +[Term] +id: GO:0009062 +name: fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] +synonym: "fatty acid breakdown" EXACT [] +synonym: "fatty acid catabolism" EXACT [] +synonym: "fatty acid degradation" EXACT [] +xref: Wikipedia:Fatty_acid_degradation +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0009063 +name: cellular amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] +synonym: "amino acid catabolic process" EXACT [] +synonym: "cellular amino acid breakdown" EXACT [] +synonym: "cellular amino acid catabolism" EXACT [] +synonym: "cellular amino acid degradation" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0009064 +name: glutamine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +synonym: "glutamine family amino acid metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0009065 +name: glutamine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +synonym: "glutamine family amino acid breakdown" EXACT [] +synonym: "glutamine family amino acid catabolism" EXACT [] +synonym: "glutamine family amino acid degradation" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0009066 +name: aspartate family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +synonym: "aspartate family amino acid metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0009067 +name: aspartate family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +synonym: "aspartate family amino acid anabolism" EXACT [] +synonym: "aspartate family amino acid biosynthesis" EXACT [] +synonym: "aspartate family amino acid formation" EXACT [] +synonym: "aspartate family amino acid synthesis" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009068 +name: aspartate family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] +synonym: "aspartate family amino acid breakdown" EXACT [] +synonym: "aspartate family amino acid catabolism" EXACT [] +synonym: "aspartate family amino acid degradation" EXACT [] +is_a: GO:0009066 ! aspartate family amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0009069 +name: serine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +synonym: "serine family amino acid metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0009070 +name: serine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +synonym: "serine family amino acid anabolism" EXACT [] +synonym: "serine family amino acid biosynthesis" EXACT [] +synonym: "serine family amino acid formation" EXACT [] +synonym: "serine family amino acid synthesis" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009071 +name: serine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] +synonym: "serine family amino acid breakdown" EXACT [] +synonym: "serine family amino acid catabolism" EXACT [] +synonym: "serine family amino acid degradation" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0009072 +name: aromatic amino acid family metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +synonym: "aromatic amino acid family metabolism" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0009073 +name: aromatic amino acid family biosynthetic process +namespace: biological_process +alt_id: GO:0016089 +def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +synonym: "aromatic amino acid family anabolism" EXACT [] +synonym: "aromatic amino acid family biosynthesis" EXACT [] +synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] +synonym: "aromatic amino acid family formation" EXACT [] +synonym: "aromatic amino acid family synthesis" EXACT [] +xref: MetaCyc:COMPLETE-ARO-PWY +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009074 +name: aromatic amino acid family catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] +synonym: "aromatic amino acid family breakdown" EXACT [] +synonym: "aromatic amino acid family catabolism" EXACT [] +synonym: "aromatic amino acid family degradation" EXACT [] +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0009075 +name: obsolete histidine family amino acid metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. +synonym: "histidine family amino acid metabolic process" EXACT [] +synonym: "histidine family amino acid metabolism" EXACT [] +is_obsolete: true +replaced_by: GO:0006547 + +[Term] +id: GO:0009076 +name: obsolete histidine family amino acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. +synonym: "histidine family amino acid anabolism" EXACT [] +synonym: "histidine family amino acid biosynthesis" EXACT [] +synonym: "histidine family amino acid biosynthetic process" EXACT [] +synonym: "histidine family amino acid formation" EXACT [] +synonym: "histidine family amino acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0000105 + +[Term] +id: GO:0009077 +name: obsolete histidine family amino acid catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. +synonym: "histidine family amino acid breakdown" EXACT [] +synonym: "histidine family amino acid catabolic process" EXACT [] +synonym: "histidine family amino acid catabolism" EXACT [] +synonym: "histidine family amino acid degradation" EXACT [] +is_obsolete: true +replaced_by: GO:0006548 + +[Term] +id: GO:0009078 +name: pyruvate family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +synonym: "pyruvate family amino acid metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0009079 +name: pyruvate family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +synonym: "pyruvate family amino acid anabolism" EXACT [] +synonym: "pyruvate family amino acid biosynthesis" EXACT [] +synonym: "pyruvate family amino acid formation" EXACT [] +synonym: "pyruvate family amino acid synthesis" EXACT [] +is_a: GO:0009078 ! pyruvate family amino acid metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009080 +name: pyruvate family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] +synonym: "pyruvate family amino acid breakdown" EXACT [] +synonym: "pyruvate family amino acid catabolism" EXACT [] +synonym: "pyruvate family amino acid degradation" EXACT [] +is_a: GO:0009078 ! pyruvate family amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0009081 +name: branched-chain amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +synonym: "branched chain family amino acid metabolism" EXACT [GOC:ai] +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0009082 +name: branched-chain amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +synonym: "branched chain family amino acid anabolism" EXACT [] +synonym: "branched chain family amino acid biosynthesis" EXACT [] +synonym: "branched chain family amino acid biosynthetic process" EXACT [GOC:ai] +synonym: "branched chain family amino acid formation" EXACT [] +synonym: "branched chain family amino acid synthesis" EXACT [] +is_a: GO:0009081 ! branched-chain amino acid metabolic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009083 +name: branched-chain amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] +synonym: "branched chain family amino acid breakdown" EXACT [] +synonym: "branched chain family amino acid catabolic process" EXACT [GOC:ai] +synonym: "branched chain family amino acid catabolism" EXACT [] +synonym: "branched chain family amino acid degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009081 ! branched-chain amino acid metabolic process + +[Term] +id: GO:0009084 +name: glutamine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] +synonym: "glutamine family amino acid anabolism" EXACT [] +synonym: "glutamine family amino acid biosynthesis" EXACT [] +synonym: "glutamine family amino acid formation" EXACT [] +synonym: "glutamine family amino acid synthesis" EXACT [] +is_a: GO:0009064 ! glutamine family amino acid metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009085 +name: lysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] +synonym: "lysine anabolism" EXACT [] +synonym: "lysine biosynthesis" EXACT [] +synonym: "lysine formation" EXACT [] +synonym: "lysine synthesis" EXACT [] +xref: MetaCyc:PWY-5097 +is_a: GO:0006553 ! lysine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009086 +name: methionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "methionine anabolism" EXACT [] +synonym: "methionine biosynthesis" EXACT [] +synonym: "methionine formation" EXACT [] +synonym: "methionine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009087 +name: methionine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "methionine breakdown" EXACT [] +synonym: "methionine catabolism" EXACT [] +synonym: "methionine degradation" EXACT [] +xref: UM-BBD_pathwayID:met +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0006555 ! methionine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process + +[Term] +id: GO:0009088 +name: threonine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +synonym: "threonine anabolism" EXACT [] +synonym: "threonine biosynthesis" EXACT [] +synonym: "threonine formation" EXACT [] +synonym: "threonine synthesis" EXACT [] +xref: MetaCyc:HOMOSER-THRESYN-PWY +xref: MetaCyc:THRESYN-PWY +is_a: GO:0006566 ! threonine metabolic process +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process + +[Term] +id: GO:0009089 +name: lysine biosynthetic process via diaminopimelate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] +synonym: "diaminopimelate pathway" EXACT [] +synonym: "diaminopimelic acid pathway" EXACT [] +synonym: "lysine anabolism via diaminopimelate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] +synonym: "lysine formation via diaminopimelate" EXACT [] +synonym: "lysine synthesis via diaminopimelate" EXACT [] +is_a: GO:0009085 ! lysine biosynthetic process +is_a: GO:0046451 ! diaminopimelate metabolic process + +[Term] +id: GO:0009090 +name: homoserine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] +synonym: "homoserine anabolism" EXACT [] +synonym: "homoserine biosynthesis" EXACT [] +synonym: "homoserine formation" EXACT [] +synonym: "homoserine synthesis" EXACT [] +xref: MetaCyc:HOMOSERSYN-PWY +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0009091 +name: homoserine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] +synonym: "homoserine breakdown" EXACT [] +synonym: "homoserine catabolism" EXACT [] +synonym: "homoserine degradation" EXACT [] +xref: MetaCyc:HOMOCYSDEGR-PWY +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process +is_a: GO:0009092 ! homoserine metabolic process + +[Term] +id: GO:0009092 +name: homoserine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732] +synonym: "homoserine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0009093 +name: cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +synonym: "cysteine breakdown" EXACT [] +synonym: "cysteine catabolism" EXACT [] +synonym: "cysteine degradation" EXACT [] +xref: Wikipedia:Cysteine +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009071 ! serine family amino acid catabolic process + +[Term] +id: GO:0009094 +name: L-phenylalanine biosynthetic process +namespace: biological_process +alt_id: GO:0019274 +alt_id: GO:0019275 +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [GOC:jsg, GOC:mah] +synonym: "L-phenylalanine anabolism" EXACT [] +synonym: "L-phenylalanine biosynthesis" EXACT [] +synonym: "L-phenylalanine formation" EXACT [] +synonym: "L-phenylalanine synthesis" EXACT [] +synonym: "phenylalanine biosynthesis" BROAD [] +synonym: "phenylalanine biosynthetic process" BROAD [] +synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] +synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] +is_a: GO:0006558 ! L-phenylalanine metabolic process +is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway +is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process + +[Term] +id: GO:0009095 +name: aromatic amino acid family biosynthetic process, prephenate pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309] +synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] +synonym: "aromatic amino acid family biosynthetic process via prephenate" EXACT [GOC:pr] +synonym: "aromatic amino acid family biosynthetic process via prephenate(2-)" EXACT [GOC:pr] +synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] +synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process + +[Term] +id: GO:0009097 +name: isoleucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] +synonym: "isoleucine anabolism" EXACT [] +synonym: "isoleucine biosynthesis" EXACT [] +synonym: "isoleucine formation" EXACT [] +synonym: "isoleucine synthesis" EXACT [] +xref: MetaCyc:ILEUSYN-PWY +is_a: GO:0006549 ! isoleucine metabolic process +is_a: GO:0009082 ! branched-chain amino acid biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009098 +name: leucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] +synonym: "leucine anabolism" EXACT [] +synonym: "leucine biosynthesis" EXACT [] +synonym: "leucine formation" EXACT [] +synonym: "leucine synthesis" EXACT [] +xref: MetaCyc:LEUSYN-PWY +is_a: GO:0006551 ! leucine metabolic process +is_a: GO:0009082 ! branched-chain amino acid biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009099 +name: valine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] +synonym: "valine anabolism" EXACT [] +synonym: "valine biosynthesis" EXACT [] +synonym: "valine formation" EXACT [] +synonym: "valine synthesis" EXACT [] +xref: MetaCyc:VALSYN-PWY +is_a: GO:0006573 ! valine metabolic process +is_a: GO:0009082 ! branched-chain amino acid biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0009100 +name: glycoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +subset: goslim_drosophila +synonym: "glycoprotein metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0009101 +name: glycoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] +synonym: "glycoprotein anabolism" EXACT [] +synonym: "glycoprotein biosynthesis" EXACT [] +synonym: "glycoprotein formation" EXACT [] +synonym: "glycoprotein synthesis" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009102 +name: biotin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] +synonym: "biotin anabolism" EXACT [] +synonym: "biotin biosynthesis" EXACT [] +synonym: "biotin formation" EXACT [] +synonym: "biotin synthesis" EXACT [] +synonym: "vitamin B7 biosynthesis" EXACT [] +synonym: "vitamin B7 biosynthetic process" EXACT [] +synonym: "vitamin H biosynthesis" EXACT [] +synonym: "vitamin H biosynthetic process" EXACT [] +xref: MetaCyc:BIOTIN-SYNTHESIS-PWY +is_a: GO:0006768 ! biotin metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009103 +name: lipopolysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] +synonym: "lipopolysaccharide anabolism" EXACT [] +synonym: "lipopolysaccharide biosynthesis" EXACT [] +synonym: "lipopolysaccharide formation" EXACT [] +synonym: "lipopolysaccharide synthesis" EXACT [] +synonym: "LPS biosynthetic process" EXACT [] +xref: KEGG_PATHWAY:map00540 +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0008653 ! lipopolysaccharide metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009104 +name: lipopolysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] +synonym: "lipopolysaccharide breakdown" EXACT [] +synonym: "lipopolysaccharide catabolism" EXACT [] +synonym: "lipopolysaccharide degradation" EXACT [] +synonym: "LPS catabolic process" EXACT [] +is_a: GO:0008653 ! lipopolysaccharide metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0009106 +name: lipoate metabolic process +namespace: biological_process +alt_id: GO:0000273 +def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] +synonym: "lipoate metabolism" EXACT [] +synonym: "lipoic acid metabolic process" EXACT [] +synonym: "lipoic acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0009107 +name: lipoate biosynthetic process +namespace: biological_process +alt_id: GO:0009105 +def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] +synonym: "lipoate anabolism" EXACT [] +synonym: "lipoate biosynthesis" EXACT [] +synonym: "lipoate formation" EXACT [] +synonym: "lipoate synthesis" EXACT [] +synonym: "lipoic acid anabolism" EXACT [] +synonym: "lipoic acid biosynthesis" EXACT [] +synonym: "lipoic acid biosynthetic process" EXACT [] +synonym: "lipoic acid formation" EXACT [] +synonym: "lipoic acid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0009106 ! lipoate metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0009108 +name: obsolete coenzyme biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group biosynthetic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "coenzyme anabolism" EXACT [] +synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] +synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] +synonym: "coenzyme biosynthesis" EXACT [] +synonym: "coenzyme formation" EXACT [] +synonym: "coenzyme synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009109 +name: obsolete coenzyme catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group catabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "coenzyme and prosthetic group catabolic process" BROAD [] +synonym: "coenzyme and prosthetic group catabolism" BROAD [] +synonym: "coenzyme breakdown" EXACT [] +synonym: "coenzyme catabolism" EXACT [] +synonym: "coenzyme degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009110 +name: vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732] +synonym: "vitamin anabolism" EXACT [] +synonym: "vitamin biosynthesis" EXACT [] +synonym: "vitamin formation" EXACT [] +synonym: "vitamin synthesis" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process + +[Term] +id: GO:0009111 +name: vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +synonym: "vitamin breakdown" EXACT [] +synonym: "vitamin catabolism" EXACT [] +synonym: "vitamin degradation" EXACT [] +is_a: GO:0006766 ! vitamin metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044282 ! small molecule catabolic process + +[Term] +id: GO:0009112 +name: nucleobase metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] +synonym: "nucleobase metabolism" EXACT [] +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0009113 +name: purine nucleobase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [ISBN:0198506732] +synonym: "purine base anabolism" EXACT [] +synonym: "purine base biosynthesis" EXACT [] +synonym: "purine base biosynthetic process" EXACT [GOC:go_curators] +synonym: "purine base formation" EXACT [] +synonym: "purine base synthesis" EXACT [] +xref: MetaCyc:PWY-841 +is_a: GO:0006144 ! purine nucleobase metabolic process +is_a: GO:0046112 ! nucleobase biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0009114 +name: hypoxanthine catabolic process +namespace: biological_process +alt_id: GO:0006150 +def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [PMID:3196295] +synonym: "hypoxanthine breakdown" EXACT [] +synonym: "hypoxanthine catabolism" EXACT [] +synonym: "hypoxanthine degradation" EXACT [] +synonym: "hypoxanthine oxidation" NARROW [] +is_a: GO:0006145 ! purine nucleobase catabolic process +is_a: GO:0046100 ! hypoxanthine metabolic process + +[Term] +id: GO:0009115 +name: xanthine catabolic process +namespace: biological_process +alt_id: GO:0006151 +def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +synonym: "xanthine breakdown" EXACT [] +synonym: "xanthine catabolism" EXACT [] +synonym: "xanthine degradation" EXACT [] +synonym: "xanthine oxidation" NARROW [] +is_a: GO:0006145 ! purine nucleobase catabolic process +is_a: GO:0046110 ! xanthine metabolic process + +[Term] +id: GO:0009116 +name: nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] +subset: goslim_pir +synonym: "nucleoside metabolism" EXACT [] +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:0009117 +name: nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] +subset: goslim_pir +synonym: "nucleotide metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009118 +name: regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +synonym: "regulation of nucleoside metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009119 +name: ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] +synonym: "ribonucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009120 +name: deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +synonym: "deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0009123 +name: nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009124 +name: nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside monophosphate anabolism" EXACT [] +synonym: "nucleoside monophosphate biosynthesis" EXACT [] +synonym: "nucleoside monophosphate formation" EXACT [] +synonym: "nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0009125 +name: nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside monophosphate breakdown" EXACT [] +synonym: "nucleoside monophosphate catabolism" EXACT [] +synonym: "nucleoside monophosphate degradation" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:1901292 ! nucleoside phosphate catabolic process + +[Term] +id: GO:0009126 +name: purine nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009127 +name: purine nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside monophosphate anabolism" EXACT [] +synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine nucleoside monophosphate formation" EXACT [] +synonym: "purine nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009128 +name: purine nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside monophosphate breakdown" EXACT [] +synonym: "purine nucleoside monophosphate catabolism" EXACT [] +synonym: "purine nucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009129 +name: pyrimidine nucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009130 +name: pyrimidine nucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009131 +name: pyrimidine nucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process + +[Term] +id: GO:0009132 +name: nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009133 +name: nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside diphosphate anabolism" EXACT [] +synonym: "nucleoside diphosphate biosynthesis" EXACT [] +synonym: "nucleoside diphosphate formation" EXACT [] +synonym: "nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0009134 +name: nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside diphosphate breakdown" EXACT [] +synonym: "nucleoside diphosphate catabolism" EXACT [] +synonym: "nucleoside diphosphate degradation" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process +is_a: GO:1901292 ! nucleoside phosphate catabolic process + +[Term] +id: GO:0009135 +name: purine nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009136 +name: purine nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside diphosphate anabolism" EXACT [] +synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside diphosphate formation" EXACT [] +synonym: "purine nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009137 +name: purine nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside diphosphate breakdown" EXACT [] +synonym: "purine nucleoside diphosphate catabolism" EXACT [] +synonym: "purine nucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009138 +name: pyrimidine nucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009139 +name: pyrimidine nucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009140 +name: pyrimidine nucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process + +[Term] +id: GO:0009141 +name: nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0009142 +name: nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside triphosphate anabolism" EXACT [] +synonym: "nucleoside triphosphate biosynthesis" EXACT [] +synonym: "nucleoside triphosphate formation" EXACT [] +synonym: "nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0009143 +name: nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "nucleoside triphosphate breakdown" EXACT [] +synonym: "nucleoside triphosphate catabolism" EXACT [] +synonym: "nucleoside triphosphate degradation" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process +is_a: GO:1901292 ! nucleoside phosphate catabolic process + +[Term] +id: GO:0009144 +name: purine nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009145 +name: purine nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside triphosphate anabolism" EXACT [] +synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside triphosphate formation" EXACT [] +synonym: "purine nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009146 +name: purine nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine nucleoside triphosphate breakdown" EXACT [] +synonym: "purine nucleoside triphosphate catabolism" EXACT [] +synonym: "purine nucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009147 +name: pyrimidine nucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009148 +name: pyrimidine nucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009149 +name: pyrimidine nucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process + +[Term] +id: GO:0009150 +name: purine ribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleotide metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009151 +name: purine deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process + +[Term] +id: GO:0009152 +name: purine ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleotide anabolism" EXACT [] +synonym: "purine ribonucleotide biosynthesis" EXACT [] +synonym: "purine ribonucleotide formation" EXACT [] +synonym: "purine ribonucleotide synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009153 +name: purine deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleotide anabolism" EXACT [] +synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] +synonym: "purine deoxyribonucleotide formation" EXACT [] +synonym: "purine deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009154 +name: purine ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleotide breakdown" EXACT [] +synonym: "purine ribonucleotide catabolism" EXACT [] +synonym: "purine ribonucleotide degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009155 +name: purine deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleotide breakdown" EXACT [] +synonym: "purine deoxyribonucleotide catabolism" EXACT [] +synonym: "purine deoxyribonucleotide degradation" EXACT [] +is_a: GO:0006195 ! purine nucleotide catabolic process +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process +is_a: GO:0046386 ! deoxyribose phosphate catabolic process + +[Term] +id: GO:0009156 +name: ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside monophosphate anabolism" EXACT [] +synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "ribonucleoside monophosphate formation" EXACT [] +synonym: "ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009157 +name: deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009158 +name: ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside monophosphate breakdown" EXACT [] +synonym: "ribonucleoside monophosphate catabolism" EXACT [] +synonym: "ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009159 +name: deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009125 ! nucleoside monophosphate catabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009161 +name: ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009162 +name: deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process + +[Term] +id: GO:0009163 +name: nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +synonym: "nucleoside anabolism" EXACT [] +synonym: "nucleoside biosynthesis" EXACT [] +synonym: "nucleoside formation" EXACT [] +synonym: "nucleoside synthesis" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901659 ! glycosyl compound biosynthetic process + +[Term] +id: GO:0009164 +name: nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] +synonym: "nucleoside breakdown" EXACT [] +synonym: "nucleoside catabolism" EXACT [] +synonym: "nucleoside degradation" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901658 ! glycosyl compound catabolic process + +[Term] +id: GO:0009165 +name: nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] +synonym: "nucleotide anabolism" EXACT [] +synonym: "nucleotide biosynthesis" EXACT [] +synonym: "nucleotide formation" EXACT [] +synonym: "nucleotide synthesis" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0009166 +name: nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] +synonym: "nucleotide breakdown" EXACT [] +synonym: "nucleotide catabolism" EXACT [] +synonym: "nucleotide degradation" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:1901292 ! nucleoside phosphate catabolic process + +[Term] +id: GO:0009167 +name: purine ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009168 +name: purine ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] +synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside monophosphate formation" EXACT [] +synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009169 +name: purine ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] +synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] +synonym: "purine ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process +is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009170 +name: purine deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009171 +name: purine deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process +is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009172 +name: purine deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process +is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009173 +name: pyrimidine ribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009174 +name: pyrimidine ribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009175 +name: pyrimidine ribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process +is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009176 +name: pyrimidine deoxyribonucleoside monophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] +is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process +is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009177 +name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] +is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process +is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009178 +name: pyrimidine deoxyribonucleoside monophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] +is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process +is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0009179 +name: purine ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009180 +name: purine ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside diphosphate formation" EXACT [] +synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process +is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process + +[Term] +id: GO:0009181 +name: purine ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process +is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process + +[Term] +id: GO:0009182 +name: purine deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009183 +name: purine deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process + +[Term] +id: GO:0009184 +name: purine deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process + +[Term] +id: GO:0009185 +name: ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009186 +name: deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009132 ! nucleoside diphosphate metabolic process + +[Term] +id: GO:0009187 +name: cyclic nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] +synonym: "cyclic nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0009188 +name: ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside diphosphate anabolism" EXACT [] +synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside diphosphate formation" EXACT [] +synonym: "ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009189 +name: deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009190 +name: cyclic nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] +synonym: "cyclic nucleotide anabolism" EXACT [] +synonym: "cyclic nucleotide biosynthesis" EXACT [] +synonym: "cyclic nucleotide formation" EXACT [] +synonym: "cyclic nucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0009191 +name: ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside diphosphate breakdown" EXACT [] +synonym: "ribonucleoside diphosphate catabolism" EXACT [] +synonym: "ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009192 +name: deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009134 ! nucleoside diphosphate catabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009193 +name: pyrimidine ribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process +is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009194 +name: pyrimidine ribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process +is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009195 +name: pyrimidine ribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process +is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009196 +name: pyrimidine deoxyribonucleoside diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] +is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process +is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009197 +name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] +is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process +is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009198 +name: pyrimidine deoxyribonucleoside diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] +is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process +is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0009199 +name: ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009200 +name: deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009141 ! nucleoside triphosphate metabolic process + +[Term] +id: GO:0009201 +name: ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside triphosphate anabolism" EXACT [] +synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside triphosphate formation" EXACT [] +synonym: "ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009202 +name: deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009203 +name: ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleoside triphosphate breakdown" EXACT [] +synonym: "ribonucleoside triphosphate catabolism" EXACT [] +synonym: "ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009204 +name: deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009143 ! nucleoside triphosphate catabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009205 +name: purine ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009206 +name: purine ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside triphosphate formation" EXACT [] +synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process +is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009207 +name: purine ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process +is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009208 +name: pyrimidine ribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process +is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009209 +name: pyrimidine ribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process +is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009210 +name: pyrimidine ribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process +is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009211 +name: pyrimidine deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009212 +name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process +is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009213 +name: pyrimidine deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process +is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009214 +name: cyclic nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] +synonym: "cyclic nucleotide breakdown" EXACT [] +synonym: "cyclic nucleotide catabolism" EXACT [] +synonym: "cyclic nucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0009215 +name: purine deoxyribonucleoside triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] +is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process +is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009216 +name: purine deoxyribonucleoside triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] +is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process +is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009217 +name: purine deoxyribonucleoside triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] +synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] +is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process +is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0009218 +name: pyrimidine ribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleotide metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process + +[Term] +id: GO:0009219 +name: pyrimidine deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process + +[Term] +id: GO:0009220 +name: pyrimidine ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleotide anabolism" EXACT [] +synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleotide formation" EXACT [] +synonym: "pyrimidine ribonucleotide synthesis" EXACT [] +xref: MetaCyc:PWY0-162 +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process + +[Term] +id: GO:0009221 +name: pyrimidine deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] +synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] +xref: MetaCyc:PWY0-166 +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process + +[Term] +id: GO:0009222 +name: pyrimidine ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine ribonucleotide breakdown" EXACT [] +synonym: "pyrimidine ribonucleotide catabolism" EXACT [] +synonym: "pyrimidine ribonucleotide degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process + +[Term] +id: GO:0009223 +name: pyrimidine deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] +is_a: GO:0006244 ! pyrimidine nucleotide catabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0009264 ! deoxyribonucleotide catabolic process +is_a: GO:0046386 ! deoxyribose phosphate catabolic process + +[Term] +id: GO:0009224 +name: CMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732] +synonym: "CMP anabolism" EXACT [] +synonym: "CMP biosynthesis" EXACT [] +synonym: "CMP formation" EXACT [] +synonym: "CMP synthesis" EXACT [] +is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046035 ! CMP metabolic process + +[Term] +id: GO:0009225 +name: nucleotide-sugar metabolic process +namespace: biological_process +def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] +subset: goslim_pir +synonym: "nucleotide-sugar metabolism" EXACT [] +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0009226 +name: nucleotide-sugar biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] +synonym: "nucleotide-sugar anabolism" EXACT [] +synonym: "nucleotide-sugar biosynthesis" EXACT [] +synonym: "nucleotide-sugar formation" EXACT [] +synonym: "nucleotide-sugar synthesis" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009227 +name: nucleotide-sugar catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] +synonym: "nucleotide-sugar breakdown" EXACT [] +synonym: "nucleotide-sugar catabolism" EXACT [] +synonym: "nucleotide-sugar degradation" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0009228 +name: thiamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] +synonym: "thiamin anabolism" EXACT [] +synonym: "thiamin biosynthetic process" EXACT [] +synonym: "thiamine biosynthesis" EXACT [] +synonym: "thiamine formation" EXACT [] +synonym: "thiamine synthesis" EXACT [] +synonym: "vitamin B1 biosynthesis" EXACT [] +synonym: "vitamin B1 biosynthetic process" EXACT [] +xref: MetaCyc:THISYN-PWY +is_a: GO:0006772 ! thiamine metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042724 ! thiamine-containing compound biosynthetic process + +[Term] +id: GO:0009229 +name: thiamine diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713] +synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators] +synonym: "thiamin pyrophosphate biosynthesis" EXACT [] +synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] +synonym: "thiamine diphosphate anabolism" EXACT [] +synonym: "thiamine diphosphate biosynthesis" EXACT [] +synonym: "thiamine diphosphate formation" EXACT [] +synonym: "thiamine diphosphate synthesis" EXACT [] +synonym: "thiamine pyrophosphate biosynthesis" EXACT [] +synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] +synonym: "TPP biosynthesis" EXACT [] +synonym: "TPP biosynthetic process" EXACT [] +is_a: GO:0042357 ! thiamine diphosphate metabolic process +is_a: GO:0042724 ! thiamine-containing compound biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0009230 +name: thiamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732] +synonym: "thiamin catabolic process" EXACT [] +synonym: "thiamine breakdown" EXACT [] +synonym: "thiamine catabolism" EXACT [] +synonym: "thiamine degradation" EXACT [] +synonym: "vitamin B1 catabolic process" EXACT [] +synonym: "vitamin B1 catabolism" EXACT [] +is_a: GO:0006772 ! thiamine metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0042725 ! thiamine-containing compound catabolic process + +[Term] +id: GO:0009231 +name: riboflavin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "riboflavin anabolism" EXACT [] +synonym: "riboflavin biosynthesis" EXACT [] +synonym: "riboflavin formation" EXACT [] +synonym: "riboflavin synthesis" EXACT [] +synonym: "vitamin B2 biosynthesis" EXACT [] +synonym: "vitamin B2 biosynthetic process" EXACT [] +synonym: "vitamin G biosynthesis" EXACT [] +synonym: "vitamin G biosynthetic process" EXACT [] +xref: MetaCyc:RIBOSYN2-PWY +xref: Wikipedia:Riboflavin +is_a: GO:0006771 ! riboflavin metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042727 ! flavin-containing compound biosynthetic process + +[Term] +id: GO:0009232 +name: riboflavin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "riboflavin breakdown" EXACT [] +synonym: "riboflavin catabolism" EXACT [] +synonym: "riboflavin degradation" EXACT [] +synonym: "vitamin B2 catabolic process" EXACT [] +synonym: "vitamin B2 catabolism" EXACT [] +synonym: "vitamin G catabolic process" EXACT [] +synonym: "vitamin G catabolism" EXACT [] +is_a: GO:0006771 ! riboflavin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042728 ! flavin-containing compound catabolic process + +[Term] +id: GO:0009233 +name: menaquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "menaquinone metabolism" EXACT [] +synonym: "menatetrenone metabolic process" EXACT [] +synonym: "menatetrenone metabolism" EXACT [] +synonym: "multiprenylmenaquinone metabolic process" EXACT [] +synonym: "multiprenylmenaquinone metabolism" EXACT [] +synonym: "vitamin K2 metabolic process" EXACT [] +synonym: "vitamin K2 metabolism" EXACT [] +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:0009234 +name: menaquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "menaquinone anabolism" EXACT [] +synonym: "menaquinone biosynthesis" EXACT [] +synonym: "menaquinone formation" EXACT [] +synonym: "menaquinone synthesis" EXACT [] +synonym: "menatetrenone biosynthesis" EXACT [] +synonym: "menatetrenone biosynthetic process" EXACT [] +synonym: "multiprenylmenaquinone biosynthesis" EXACT [] +synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] +synonym: "vitamin K2 biosynthesis" EXACT [] +synonym: "vitamin K2 biosynthetic process" EXACT [] +xref: MetaCyc:MENAQUINONESYN-PWY +is_a: GO:0009233 ! menaquinone metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0009235 +name: cobalamin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] +synonym: "cobalamin metabolism" EXACT [] +synonym: "vitamin B12 metabolic process" EXACT [] +synonym: "vitamin B12 metabolism" EXACT [] +synonym: "vitamin B12 reduction" NARROW [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0009236 +name: cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732] +synonym: "cobalamin anabolism" EXACT [] +synonym: "cobalamin biosynthesis" EXACT [] +synonym: "cobalamin formation" EXACT [] +synonym: "cobalamin synthesis" EXACT [] +synonym: "vitamin B12 biosynthesis" EXACT [] +synonym: "vitamin B12 biosynthetic process" EXACT [] +is_a: GO:0009235 ! cobalamin metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process + +[Term] +id: GO:0009237 +name: siderophore metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] +synonym: "siderochrome metabolic process" NARROW [] +synonym: "siderochrome metabolism" NARROW [] +synonym: "siderophore metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0009238 +name: enterobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] +synonym: "enterobactin metabolism" EXACT [] +synonym: "enterochelin metabolic process" EXACT [] +synonym: "enterochelin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0033067 ! macrolide metabolic process + +[Term] +id: GO:0009239 +name: enterobactin biosynthetic process +namespace: biological_process +alt_id: GO:0031191 +alt_id: GO:0031192 +def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] +synonym: "enterobactin anabolism" EXACT [] +synonym: "enterobactin biosynthesis" EXACT [] +synonym: "enterobactin biosynthetic process, peptide formation" NARROW [] +synonym: "enterobactin biosynthetic process, peptide modification" NARROW [] +synonym: "enterobactin formation" EXACT [] +synonym: "enterobactin synthesis" EXACT [] +synonym: "enterobactin synthetase" RELATED [] +synonym: "enterochelin biosynthesis" EXACT [] +synonym: "enterochelin biosynthetic process" EXACT [] +xref: MetaCyc:ENTBACSYN-PWY +is_a: GO:0009238 ! enterobactin metabolic process +is_a: GO:0019540 ! catechol-containing siderophore biosynthetic process +is_a: GO:0033068 ! macrolide biosynthetic process + +[Term] +id: GO:0009240 +name: isopentenyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732] +synonym: "IPP biosynthesis" EXACT [] +synonym: "IPP biosynthetic process" EXACT [] +synonym: "isopentenyl diphosphate anabolism" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis" EXACT [] +synonym: "isopentenyl diphosphate formation" EXACT [] +synonym: "isopentenyl diphosphate synthesis" EXACT [] +synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] +synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0046490 ! isopentenyl diphosphate metabolic process +relationship: part_of GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:0009242 +name: colanic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] +synonym: "colanic acid anabolism" EXACT [] +synonym: "colanic acid biosynthesis" EXACT [] +synonym: "colanic acid formation" EXACT [] +synonym: "colanic acid synthesis" EXACT [] +synonym: "M antigen biosynthesis" EXACT [] +synonym: "M antigen biosynthetic process" EXACT [] +xref: MetaCyc:COLANSYN-PWY +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046377 ! colanic acid metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009243 +name: O antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732] +synonym: "O antigen anabolism" EXACT [] +synonym: "O antigen biosynthesis" EXACT [] +synonym: "O antigen formation" EXACT [] +synonym: "O antigen synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046402 ! O antigen metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0009244 +name: lipopolysaccharide core region biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732] +synonym: "lipopolysaccharide core region anabolism" EXACT [] +synonym: "lipopolysaccharide core region biosynthesis" EXACT [] +synonym: "lipopolysaccharide core region formation" EXACT [] +synonym: "lipopolysaccharide core region synthesis" EXACT [] +synonym: "LPS core region biosynthetic process" EXACT [] +is_a: GO:0009312 ! oligosaccharide biosynthetic process +is_a: GO:0046401 ! lipopolysaccharide core region metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0009245 +name: lipid A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004] +synonym: "lipid A anabolism" EXACT [] +synonym: "lipid A biosynthesis" EXACT [] +synonym: "lipid A formation" EXACT [] +synonym: "lipid A synthesis" EXACT [] +xref: MetaCyc:NAGLIPASYN-PWY +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0046493 ! lipid A metabolic process +is_a: GO:1901271 ! lipooligosaccharide biosynthetic process + +[Term] +id: GO:0009246 +name: enterobacterial common antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] +synonym: "enterobacterial common antigen anabolism" EXACT [] +synonym: "enterobacterial common antigen biosynthesis" EXACT [] +synonym: "enterobacterial common antigen formation" EXACT [] +synonym: "enterobacterial common antigen synthesis" EXACT [] +xref: MetaCyc:ECASYN-PWY +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046378 ! enterobacterial common antigen metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009247 +name: glycolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] +synonym: "glycolipid anabolism" EXACT [] +synonym: "glycolipid biosynthesis" EXACT [] +synonym: "glycolipid formation" EXACT [] +synonym: "glycolipid synthesis" EXACT [] +xref: MetaCyc:PWY-401 +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0046467 ! membrane lipid biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009248 +name: K antigen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732] +synonym: "K antigen anabolism" EXACT [] +synonym: "K antigen biosynthesis" EXACT [] +synonym: "K antigen formation" EXACT [] +synonym: "K antigen synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046375 ! K antigen metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009249 +name: protein lipoylation +namespace: biological_process +alt_id: GO:0018055 +def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] +synonym: "peptidyl-lysine lipoylation" EXACT [] +synonym: "protein-lipoic acid cofactor linkage" EXACT [] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0009250 +name: glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] +synonym: "glucan anabolism" EXACT [] +synonym: "glucan biosynthesis" EXACT [] +synonym: "glucan formation" EXACT [] +synonym: "glucan synthesis" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0009251 +name: glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] +synonym: "glucan breakdown" EXACT [] +synonym: "glucan catabolism" EXACT [] +synonym: "glucan degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0044042 ! glucan metabolic process + +[Term] +id: GO:0009252 +name: peptidoglycan biosynthetic process +namespace: biological_process +alt_id: GO:0009285 +def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] +synonym: "murein biosynthesis" EXACT [] +synonym: "murein biosynthetic process" EXACT [] +synonym: "peptidoglycan anabolism" EXACT [] +synonym: "peptidoglycan biosynthesis" EXACT [] +synonym: "peptidoglycan formation" EXACT [] +synonym: "peptidoglycan synthesis" EXACT [] +is_a: GO:0000270 ! peptidoglycan metabolic process +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0009253 +name: peptidoglycan catabolic process +namespace: biological_process +alt_id: GO:0009286 +def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] +synonym: "murein catabolic process" EXACT [] +synonym: "murein catabolism" EXACT [] +synonym: "peptidoglycan breakdown" EXACT [] +synonym: "peptidoglycan catabolism" EXACT [] +synonym: "peptidoglycan degradation" EXACT [] +is_a: GO:0000270 ! peptidoglycan metabolic process +is_a: GO:0006027 ! glycosaminoglycan catabolic process + +[Term] +id: GO:0009254 +name: peptidoglycan turnover +namespace: biological_process +alt_id: GO:0009287 +def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] +synonym: "murein turnover" EXACT [] +is_a: GO:0000270 ! peptidoglycan metabolic process + +[Term] +id: GO:0009255 +name: Entner-Doudoroff pathway through 6-phosphogluconate +namespace: biological_process +def: "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY-I, PMID:12921356, PMID:12981024] +xref: MetaCyc:ENTNER-DOUDOROFF-PWY-I +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0061678 ! Entner-Doudoroff pathway + +[Term] +id: GO:0009256 +name: 10-formyltetrahydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +synonym: "10-formyl-THF metabolic process" EXACT [] +synonym: "10-formyl-THF metabolism" EXACT [] +synonym: "10-formyltetrahydrofolate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046653 ! tetrahydrofolate metabolic process + +[Term] +id: GO:0009257 +name: 10-formyltetrahydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +synonym: "10-formyl-THF biosynthesis" EXACT [] +synonym: "10-formyl-THF biosynthetic process" EXACT [] +synonym: "10-formyltetrahydrofolate anabolism" EXACT [] +synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] +synonym: "10-formyltetrahydrofolate formation" EXACT [] +synonym: "10-formyltetrahydrofolate synthesis" EXACT [] +xref: MetaCyc:1CMET2-PWY +xref: MetaCyc:PWY-3841 +is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046654 ! tetrahydrofolate biosynthetic process + +[Term] +id: GO:0009258 +name: 10-formyltetrahydrofolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] +synonym: "10-formyl-THF catabolic process" EXACT [] +synonym: "10-formyl-THF catabolism" EXACT [] +synonym: "10-formyltetrahydrofolate breakdown" EXACT [] +synonym: "10-formyltetrahydrofolate catabolism" EXACT [] +synonym: "10-formyltetrahydrofolate degradation" EXACT [] +is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process +is_a: GO:0009397 ! folic acid-containing compound catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0009259 +name: ribonucleotide metabolic process +namespace: biological_process +alt_id: GO:0009121 +def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0019693 ! ribose phosphate metabolic process + +[Term] +id: GO:0009260 +name: ribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleotide anabolism" EXACT [] +synonym: "ribonucleotide biosynthesis" EXACT [] +synonym: "ribonucleotide formation" EXACT [] +synonym: "ribonucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009259 ! ribonucleotide metabolic process +is_a: GO:0046390 ! ribose phosphate biosynthetic process + +[Term] +id: GO:0009261 +name: ribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "ribonucleotide breakdown" EXACT [] +synonym: "ribonucleotide catabolism" EXACT [] +synonym: "ribonucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0009262 +name: deoxyribonucleotide metabolic process +namespace: biological_process +alt_id: GO:0009122 +alt_id: GO:0009393 +def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0009263 +name: deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleotide anabolism" EXACT [] +synonym: "deoxyribonucleotide biosynthesis" EXACT [] +synonym: "deoxyribonucleotide formation" EXACT [] +synonym: "deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0009264 +name: deoxyribonucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] +synonym: "deoxyribonucleotide breakdown" EXACT [] +synonym: "deoxyribonucleotide catabolism" EXACT [] +synonym: "deoxyribonucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0009262 ! deoxyribonucleotide metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0009265 +name: 2'-deoxyribonucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] +synonym: "2'-deoxyribonucleotide anabolism" EXACT [] +synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] +synonym: "2'-deoxyribonucleotide formation" EXACT [] +synonym: "2'-deoxyribonucleotide synthesis" EXACT [] +is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process +is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process +is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process + +[Term] +id: GO:0009266 +name: response to temperature stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] +synonym: "response to thermal stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009267 +name: cellular response to starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] +is_a: GO:0031669 ! cellular response to nutrient levels +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0009268 +name: response to pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, Wikipedia:PH] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009269 +name: response to desiccation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] +synonym: "desiccation tolerance" RELATED [] +is_a: GO:0009414 ! response to water deprivation + +[Term] +id: GO:0009270 +name: response to humidity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009271 +name: phage shock +namespace: biological_process +def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] +is_a: GO:0006950 ! response to stress +is_a: GO:0098586 ! cellular response to virus + +[Term] +id: GO:0009272 +name: fungal-type cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] +synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah] +synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah] +synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah] +synonym: "fungal-type cell wall formation" RELATED [GOC:mah] +synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah] +is_a: GO:0042546 ! cell wall biogenesis +is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis + +[Term] +id: GO:0009273 +name: peptidoglycan-based cell wall biogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators] +synonym: "cell envelope biosynthesis" BROAD [] +synonym: "cell envelope biosynthetic process" BROAD [] +synonym: "cell wall anabolism" BROAD [] +synonym: "cell wall assembly" BROAD [] +synonym: "cell wall biosynthetic process" BROAD [] +synonym: "cell wall formation" BROAD [] +synonym: "cell wall synthesis" BROAD [] +is_a: GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0009274 +name: peptidoglycan-based cell wall +namespace: cellular_component +def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893] +synonym: "envelope" BROAD [] +synonym: "murein sacculus" RELATED [] +synonym: "peptidoglycan" NARROW [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009275 +name: Gram-positive-bacterium-type cell wall +namespace: cellular_component +def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0815108893] +synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] +synonym: "cell wall of Gram-positive Bacteria" EXACT [] +is_a: GO:0009274 ! peptidoglycan-based cell wall + +[Term] +id: GO:0009276 +name: Gram-negative-bacterium-type cell wall +namespace: cellular_component +def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] +subset: goslim_metagenomics +synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] +synonym: "cell wall inner membrane" EXACT [] +is_a: GO:0009274 ! peptidoglycan-based cell wall +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0009277 +name: fungal-type cell wall +namespace: cellular_component +def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] +synonym: "beta-glucan-containing cell wall" RELATED [] +synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] +synonym: "chitin-containing cell wall" RELATED [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009278 +name: obsolete murein sacculus +namespace: cellular_component +def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "murein sacculus" EXACT [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0009279 +name: cell outer membrane +namespace: cellular_component +def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254] +comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886. +synonym: "outer membrane of cell" EXACT [] +is_a: GO:0019867 ! outer membrane +relationship: part_of GO:0030312 ! external encapsulating structure +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0009280 +name: obsolete cell wall inner membrane +namespace: cellular_component +def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "cell wall inner membrane" EXACT [] +synonym: "cytoplasmic membrane" BROAD [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0009288 +name: bacterial-type flagellum +namespace: cellular_component +def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "flagellin-based flagellum" EXACT [] +is_a: GO:0042995 ! cell projection +is_a: GO:0043228 ! non-membrane-bounded organelle + +[Term] +id: GO:0009289 +name: pilus +namespace: cellular_component +def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators, PMID:28496159] +subset: goslim_pir +synonym: "fimbria" EXACT [] +synonym: "fimbriae" EXACT [] +synonym: "fimbrium" EXACT [] +synonym: "pili" EXACT [] +xref: Wikipedia:Pilus +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0009290 +name: DNA import into cell involved in transformation +namespace: biological_process +def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] +synonym: "cellular DNA import during transformation" RELATED [] +synonym: "cellular DNA uptake" BROAD [] +synonym: "DNA import into cell" BROAD [] +synonym: "DNA transport into cell during transformation" RELATED [] +is_a: GO:0051027 ! DNA transport +is_a: GO:0098657 ! import into cell +relationship: part_of GO:0009294 ! DNA mediated transformation + +[Term] +id: GO:0009291 +name: unidirectional conjugation +namespace: biological_process +def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in prokaryotes." [ISBN:0387520546] +is_a: GO:0000746 ! conjugation +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009292 +name: genetic transfer +namespace: biological_process +def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] +comment: GO:0009292 should not be used for annotation of phage lysogeny (integration of the bacteriophage nucleic acid into the host bacterium's genome). +subset: goslim_pir +synonym: "genetic exchange" BROAD [] +is_a: GO:0044764 ! multi-organism cellular process + +[Term] +id: GO:0009293 +name: transduction +namespace: biological_process +def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732] +xref: Wikipedia:Transduction_(genetics) +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009294 +name: DNA mediated transformation +namespace: biological_process +def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)] +synonym: "DNA-mediated transformation" EXACT [] +is_a: GO:0009292 ! genetic transfer + +[Term] +id: GO:0009295 +name: nucleoid +namespace: cellular_component +def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] +xref: Wikipedia:Nucleoid +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0009296 +name: obsolete flagellum assembly +namespace: biological_process +def: "OBSOLETE. The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194] +synonym: "flagella assembly" EXACT [GOC:mah] +synonym: "flagella biogenesis" RELATED [] +synonym: "flagellum assembly" EXACT [] +synonym: "flagellum biogenesis" RELATED [GOC:mah] +is_obsolete: true +consider: GO:0044780 +consider: GO:0060271 + +[Term] +id: GO:0009297 +name: pilus assembly +namespace: biological_process +def: "The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb] +synonym: "fimbria assembly" NARROW [] +synonym: "fimbria biogenesis" RELATED [] +synonym: "fimbriae assembly" NARROW [] +synonym: "fimbriae biogenesis" RELATED [] +synonym: "fimbrial assembly" NARROW [] +synonym: "fimbrium assembly" NARROW [] +synonym: "fimbrium biogenesis" RELATED [] +synonym: "pilus biogenesis" RELATED [] +synonym: "pilus formation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0030031 ! cell projection assembly +is_a: GO:0043711 ! pilus organization + +[Term] +id: GO:0009298 +name: GDP-mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-mannose anabolism" EXACT [] +synonym: "GDP-mannose biosynthesis" EXACT [] +synonym: "GDP-mannose formation" EXACT [] +synonym: "GDP-mannose synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019673 ! GDP-mannose metabolic process + +[Term] +id: GO:0009299 +name: mRNA transcription +namespace: biological_process +alt_id: GO:0061023 +def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] +synonym: "cellular mRNA transcription" EXACT [] +synonym: "mRNA biosynthesis" BROAD [] +synonym: "mRNA biosynthetic process" BROAD [] +synonym: "mRNA synthesis" BROAD [] +is_a: GO:0006351 ! transcription, DNA-templated +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0009300 +name: antisense RNA transcription +namespace: biological_process +def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl] +is_a: GO:0042868 ! antisense RNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0009301 +name: snRNA transcription +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] +is_a: GO:0016073 ! snRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0009302 +name: sno(s)RNA transcription +namespace: biological_process +def: "The synthesis of snoRNA class RNA (also referred to as sRNA in Archaea) from a DNA template." [GOC:jl, GOC:krc, PMID:17284456] +synonym: "snoRNA transcription" NARROW [] +synonym: "sRNA transcription" NARROW [] +is_a: GO:0016074 ! sno(s)RNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0009303 +name: rRNA transcription +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] +synonym: "rRNA biosynthesis" BROAD [] +synonym: "rRNA biosynthetic process" BROAD [] +synonym: "rRNA synthesis" BROAD [] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0009304 +name: tRNA transcription +namespace: biological_process +def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] +synonym: "tRNA biosynthesis" BROAD [] +synonym: "tRNA biosynthetic process" BROAD [] +synonym: "tRNA synthesis" BROAD [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0009305 +name: protein biotinylation +namespace: biological_process +def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] +synonym: "protein amino acid biotinylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0009306 +name: protein secretion +namespace: biological_process +alt_id: GO:0045166 +alt_id: GO:0045731 +def: "The controlled release of proteins from a cell." [GOC:ai] +synonym: "glycoprotein secretion" NARROW [] +synonym: "protein secretion during cell fate commitment" NARROW [] +synonym: "protein secretion resulting in cell fate commitment" NARROW [] +is_a: GO:0015031 ! protein transport +is_a: GO:0032940 ! secretion by cell +is_a: GO:0035592 ! establishment of protein localization to extracellular region + +[Term] +id: GO:0009307 +name: DNA restriction-modification system +namespace: biological_process +def: "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680] +synonym: "DNA restriction" BROAD [] +is_a: GO:0006304 ! DNA modification +is_a: GO:0044355 ! clearance of foreign intracellular DNA + +[Term] +id: GO:0009308 +name: amine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_pir +synonym: "amine metabolism" EXACT [] +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0009309 +name: amine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] +synonym: "amine anabolism" EXACT [] +synonym: "amine biosynthesis" EXACT [] +synonym: "amine formation" EXACT [] +synonym: "amine synthesis" EXACT [] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009310 +name: amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] +synonym: "amine breakdown" EXACT [] +synonym: "amine catabolism" EXACT [] +synonym: "amine degradation" EXACT [] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0009311 +name: oligosaccharide metabolic process +namespace: biological_process +alt_id: GO:0051690 +def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] +subset: goslim_yeast +synonym: "multicellular organismal oligosaccharide metabolic process" NARROW [] +synonym: "oligosaccharide metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0009312 +name: oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] +synonym: "oligosaccharide anabolism" EXACT [] +synonym: "oligosaccharide biosynthesis" EXACT [] +synonym: "oligosaccharide formation" EXACT [] +synonym: "oligosaccharide synthesis" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0016051 ! carbohydrate biosynthetic process + +[Term] +id: GO:0009313 +name: oligosaccharide catabolic process +namespace: biological_process +alt_id: GO:0051689 +def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] +synonym: "multicellular organismal oligosaccharide catabolic process" NARROW [] +synonym: "oligosaccharide breakdown" EXACT [] +synonym: "oligosaccharide catabolism" EXACT [] +synonym: "oligosaccharide degradation" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0009314 +name: response to radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] +comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. +synonym: "response to electromagnetic radiation stimulus" EXACT [] +synonym: "response to radiation stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009315 +name: obsolete drug resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "drug resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0009410 + +[Term] +id: GO:0009316 +name: 3-isopropylmalate dehydratase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530] +comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. +synonym: "isopropylmalate isomerase complex" EXACT [] +xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0009317 +name: acetyl-CoA carboxylase complex +namespace: cellular_component +def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "ACCase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009318 +name: exodeoxyribonuclease VII complex +namespace: cellular_component +def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0009319 +name: cytochrome o ubiquinol oxidase complex +namespace: cellular_component +def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268] +comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. +xref: MetaCyc:CYT-O-UBIOX-CPLX +is_a: GO:0070069 ! cytochrome complex +is_a: GO:1902495 ! transmembrane transporter complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009320 +name: phosphoribosylaminoimidazole carboxylase complex +namespace: cellular_component +def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] +comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009321 +name: alkyl hydroperoxide reductase complex +namespace: cellular_component +def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [GOC:jl, PMID:2649484] +comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009322 +name: trimethylamine-N-oxide reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [GOC:curators] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009323 +name: obsolete ribosomal-protein-alanine N-acetyltransferase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] +comment: This term was obsoleted because there is no evidence that this complex exists. Enzymes with that activity, such as E. coli rimJ (UniProt:P0A948), act as monomoers. +is_obsolete: true + +[Term] +id: GO:0009324 +name: D-amino-acid dehydrogenase complex +namespace: cellular_component +def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] +comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009325 +name: nitrate reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009326 +name: formate dehydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [PMID:1504073, PMID:8566699] +xref: EC:1.17.1.9 +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009327 +name: NAD(P)+ transhydrogenase complex (AB-specific) +namespace: cellular_component +def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0009328 +name: phenylalanine-tRNA ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009329 +name: acetate CoA-transferase complex +namespace: cellular_component +def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex + +[Term] +id: GO:0009330 +name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex +namespace: cellular_component +def: "Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:Type_II_topoisomerase] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0009331 +name: glycerol-3-phosphate dehydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009332 +name: glutamate-tRNA ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009333 +name: cysteine synthase complex +namespace: cellular_component +def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009334 +name: 3-phenylpropionate dioxygenase complex +namespace: cellular_component +def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882] +comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. +xref: MetaCyc:HCAMULTI-CPLX +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009335 +name: obsolete holo-[acyl-carrier protein] synthase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] +comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. +synonym: "holo-[acyl-carrier protein] synthase complex" EXACT [] +synonym: "holo-ACP synthase complex" EXACT [] +is_obsolete: true +consider: GO:0005835 + +[Term] +id: GO:0009336 +name: sulfate adenylyltransferase complex (ATP) +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] +synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] +is_a: GO:1902503 ! adenylyltransferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009337 +name: sulfite reductase complex (NADPH) +namespace: cellular_component +def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl] +comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. +synonym: "sulphite reductase complex (NADPH)" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0009338 +name: exodeoxyribonuclease V complex +namespace: cellular_component +def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0009339 +name: glycolate oxidase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009340 +name: DNA topoisomerase IV complex +namespace: cellular_component +def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632] +is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex + +[Term] +id: GO:0009341 +name: beta-galactosidase complex +namespace: cellular_component +def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [PMID:15950161] +subset: goslim_metagenomics +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0009342 +name: glutamate synthase complex (NADPH) +namespace: cellular_component +def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] +is_a: GO:0031026 ! glutamate synthase complex + +[Term] +id: GO:0009343 +name: biotin carboxylase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex + +[Term] +id: GO:0009344 +name: nitrite reductase complex [NAD(P)H] +namespace: cellular_component +def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] +comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0009345 +name: glycine-tRNA ligase complex +namespace: cellular_component +def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854] +synonym: "glycine-tRNA synthetase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009346 +name: ATP-independent citrate lyase complex +namespace: cellular_component +def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria." [PMID:32302313] +comment: Note that this complex has only been found in bacteria. For eukaryotic cytrate lyases, consider GO:0140615 ; ATP-dependent citrate lyase complex. +subset: goslim_metagenomics +synonym: "citrate lyase complex" BROAD [] +synonym: "citrate synthase complex" BROAD [] +xref: MetaCyc:ACECITLY-CPLX +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009347 +name: aspartate carbamoyltransferase complex +namespace: cellular_component +def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] +comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0009348 +name: ornithine carbamoyltransferase complex +namespace: cellular_component +def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009349 +name: riboflavin synthase complex +namespace: cellular_component +def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] +subset: goslim_metagenomics +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0009350 +name: ethanolamine ammonia-lyase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0009351 +name: obsolete dihydrolipoamide S-acyltransferase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] +comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. +synonym: "dihydrolipoamide S-acyltransferase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009352 +name: obsolete dihydrolipoyl dehydrogenase complex +namespace: cellular_component +def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] +comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. +synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] +synonym: "dihydrolipoyl dehydrogenase complex" EXACT [] +is_obsolete: true +consider: GO:0004148 +consider: GO:0045240 +consider: GO:0045254 + +[Term] +id: GO:0009353 +name: mitochondrial oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975] +comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. +is_a: GO:0005947 ! mitochondrial alpha-ketoglutarate dehydrogenase complex +is_a: GO:0045252 ! oxoglutarate dehydrogenase complex + +[Term] +id: GO:0009354 +name: obsolete dihydrolipoamide S-succinyltransferase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] +comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. +synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] +is_obsolete: true +consider: GO:0045252 + +[Term] +id: GO:0009355 +name: DNA polymerase V complex +namespace: cellular_component +def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] +is_a: GO:0042575 ! DNA polymerase complex + +[Term] +id: GO:0009356 +name: aminodeoxychorismate synthase complex +namespace: cellular_component +def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] +synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] +synonym: "ADC synthase complex" EXACT [] +synonym: "p-aminobenzoate synthetase complex" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0009357 +name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +is_a: GO:1902495 ! transmembrane transporter complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009358 +name: polyphosphate kinase complex +namespace: cellular_component +def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] +comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:0009359 +name: type II site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] +synonym: "type II restriction enzyme complex" EXACT [] +is_a: GO:1905347 ! endodeoxyribonuclease complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009360 +name: DNA polymerase III complex +namespace: cellular_component +def: "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710] +synonym: "DNA polymerase III holoenzyme complex" EXACT [] +is_a: GO:0042575 ! DNA polymerase complex + +[Term] +id: GO:0009361 +name: succinate-CoA ligase complex (ADP-forming) +namespace: cellular_component +def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [GOC:jl, PMID:9874242] +synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394] +is_a: GO:0042709 ! succinate-CoA ligase complex + +[Term] +id: GO:0009365 +name: protein histidine kinase complex +namespace: cellular_component +def: "A complex that possesses protein histidine kinase activity." [GOC:mah] +is_a: GO:1902911 ! protein kinase complex + +[Term] +id: GO:0009366 +name: enterobactin synthetase complex +namespace: cellular_component +def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415] +synonym: "enterochelin synthetase complex" EXACT [] +xref: MetaCyc:ENTMULTI-CPLX +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0009367 +name: obsolete prepilin peptidase complex +namespace: cellular_component +def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] +comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer. +synonym: "prepilin peptidase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009368 +name: endopeptidase Clp complex +namespace: cellular_component +def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0009371 +name: positive regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] +synonym: "activation of transcription by pheromones" NARROW [] +synonym: "stimulation of transcription by pheromones" NARROW [] +synonym: "up regulation of transcription by pheromones" EXACT [] +synonym: "up-regulation of transcription by pheromones" EXACT [] +synonym: "upregulation of transcription by pheromones" EXACT [] +is_a: GO:0009373 ! regulation of transcription by pheromones +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated + +[Term] +id: GO:0009372 +name: quorum sensing +namespace: biological_process +alt_id: GO:0010699 +alt_id: GO:0060247 +def: "The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms." [GOC:krc, GOC:mlg, PMID:10607620, PMID:15716452, PMID:16497924, PMID:16630813, PMID:8288518] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "cell-cell signaling involved in quorum sensing" RELATED [] +synonym: "detection of cell density by secreted molecule" RELATED [] +synonym: "quorum sensing system" EXACT [] +xref: Wikipedia:Quorum_sensing +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0044764 ! multi-organism cellular process +is_a: GO:0060245 ! detection of cell density + +[Term] +id: GO:0009373 +name: regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: part_of GO:0071444 ! cellular response to pheromone + +[Term] +id: GO:0009374 +name: biotin binding +namespace: molecular_function +def: "Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732] +synonym: "vitamin B7 binding" EXACT [] +synonym: "vitamin H binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0033218 ! amide binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0009375 +name: ferredoxin hydrogenase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] +synonym: "hydrogenase complex" BROAD [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009376 +name: HslUV protease complex +namespace: cellular_component +def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer." [GOC:bhm, PMID:12670962, UniProt:P0A6H5] +synonym: "ClpYQ protease complex" EXACT [] +is_a: GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0009377 +name: obsolete HslUV protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] +comment: This term was made obsolete because it represents a gene product. +synonym: "HslUV protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008233 + +[Term] +id: GO:0009378 +name: four-way junction helicase activity +namespace: molecular_function +alt_id: GO:1990163 +def: "Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis." [GOC:al, PMID:22723423, PMID:9442895] +synonym: "ATP-dependent four-way junction DNA helicase activity" EXACT [] +synonym: "ATP-dependent four-way junction helicase activity" EXACT [] +synonym: "ATP-dependent Holliday junction helicase activity" NARROW [] +synonym: "Holliday junction helicase activity" NARROW [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0009379 +name: Holliday junction helicase complex +namespace: cellular_component +def: "A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895] +is_a: GO:0033202 ! DNA helicase complex + +[Term] +id: GO:0009380 +name: excinuclease repair complex +namespace: cellular_component +def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705] +synonym: "excinuclease ABC complex" EXACT [] +synonym: "UvrABC excinuclease complex" EXACT [] +is_a: GO:1905347 ! endodeoxyribonuclease complex +is_a: GO:1990391 ! DNA repair complex + +[Term] +id: GO:0009381 +name: excinuclease ABC activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0009382 +name: imidazoleglycerol-phosphate synthase complex +namespace: cellular_component +def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] +comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. +synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009383 +name: rRNA (cytosine-C5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] +synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] +synonym: "rRNA m5C967 methyltransferase activity" NARROW [] +xref: Reactome:R-HSA-6790944 "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447" +xref: Reactome:R-HSA-6793057 "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841" +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0009384 +name: N-acylmannosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] +synonym: "acetylamidodeoxymannokinase activity" RELATED [EC:2.7.1.60] +synonym: "acetylmannosamine kinase activity" RELATED [EC:2.7.1.60] +synonym: "acylaminodeoxymannokinase activity" RELATED [EC:2.7.1.60] +synonym: "acylmannosamine kinase (phosphorylating)" RELATED [EC:2.7.1.60] +synonym: "acylmannosamine kinase activity" RELATED [EC:2.7.1.60] +synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.60] +synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.60] +synonym: "N-acetylmannosamine kinase activity" RELATED [EC:2.7.1.60] +synonym: "N-acyl-D-mannosamine kinase activity" RELATED [EC:2.7.1.60] +xref: EC:2.7.1.60 +xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN +xref: Reactome:R-HSA-4085028 "GNE phosphorylates ManNAc to ManNAc-6-P" +xref: Reactome:R-HSA-4088322 "Defective GNE does not phosphorylate ManNAc to ManNAc-6-P" +xref: RHEA:23832 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0009385 +name: N-acylmannosamine-6-phosphate 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] +synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] +xref: EC:5.1.3.9 +xref: MetaCyc:NANE-RXN +xref: RHEA:25257 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0009386 +name: translational attenuation +namespace: biological_process +def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0009388 +name: obsolete antisense RNA +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "antisense RNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009389 +name: dimethyl sulfoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_reactionID:r0207] +synonym: "dimethyl sulphoxide reductase activity" EXACT [] +xref: EC:1.8.99.- +xref: UM-BBD_reactionID:r0207 +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0009390 +name: dimethyl sulfoxide reductase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] +synonym: "dimethyl sulphoxide reductase complex" EXACT [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0009392 +name: N-acetyl-anhydromuramoyl-L-alanine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225] +xref: MetaCyc:RXN0-5225 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0009394 +name: 2'-deoxyribonucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] +synonym: "2'-deoxyribonucleotide metabolism" EXACT [] +is_a: GO:0009262 ! deoxyribonucleotide metabolic process +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0009395 +name: phospholipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] +synonym: "phospholipid breakdown" EXACT [] +synonym: "phospholipid catabolism" EXACT [] +synonym: "phospholipid degradation" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0009396 +name: folic acid-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] +synonym: "folate and derivative biosynthesis" EXACT [] +synonym: "folate and derivative biosynthetic process" EXACT [] +synonym: "folate-containing compound biosynthesis" EXACT [] +synonym: "folate-containing compound biosynthetic process" EXACT [] +synonym: "folic acid and derivative biosynthesis" EXACT [] +synonym: "folic acid and derivative biosynthetic process" EXACT [] +synonym: "folic acid-containing compound anabolism" EXACT [] +synonym: "folic acid-containing compound biosynthesis" EXACT [] +synonym: "folic acid-containing compound formation" EXACT [] +synonym: "folic acid-containing compound synthesis" EXACT [] +synonym: "vitamin B9 and derivative biosynthesis" EXACT [] +synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] +synonym: "vitamin M and derivative biosynthesis" EXACT [] +synonym: "vitamin M and derivative biosynthetic process" EXACT [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process + +[Term] +id: GO:0009397 +name: folic acid-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] +synonym: "folate and derivative catabolic process" EXACT [] +synonym: "folate and derivative catabolism" EXACT [] +synonym: "folate-containing compound catabolic process" EXACT [] +synonym: "folate-containing compound catabolism" EXACT [] +synonym: "folic acid and derivative catabolic process" EXACT [] +synonym: "folic acid and derivative catabolism" EXACT [] +synonym: "folic acid-containing compound breakdown" EXACT [] +synonym: "folic acid-containing compound catabolism" EXACT [] +synonym: "folic acid-containing compound degradation" EXACT [] +synonym: "vitamin B9 and derivative catabolic process" EXACT [] +synonym: "vitamin B9 and derivative catabolism" EXACT [] +synonym: "vitamin M and derivative catabolic process" EXACT [] +synonym: "vitamin M and derivative catabolism" EXACT [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0042560 ! pteridine-containing compound catabolic process + +[Term] +id: GO:0009398 +name: FMN biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai] +synonym: "FMN anabolism" EXACT [] +synonym: "FMN biosynthesis" EXACT [] +synonym: "FMN formation" EXACT [] +synonym: "FMN synthesis" EXACT [] +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process +is_a: GO:0042727 ! flavin-containing compound biosynthetic process +is_a: GO:0046444 ! FMN metabolic process + +[Term] +id: GO:0009399 +name: nitrogen fixation +namespace: biological_process +def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation] +xref: MetaCyc:N2FIX-PWY +xref: Wikipedia:Nitrogen_fixation +is_a: GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:0009400 +name: obsolete signal transducer, downstream of receptor, with serine/threonine phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah] +comment: This term was obsoleted because it was not clearly defined. +synonym: "receptor signaling protein serine/threonine phosphatase activity" EXACT [] +synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009401 +name: phosphoenolpyruvate-dependent sugar phosphotransferase system +namespace: biological_process +def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] +synonym: "PTS system" NARROW [] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0009402 +name: obsolete toxin resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "toxin resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0009636 + +[Term] +id: GO:0009403 +name: toxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] +subset: goslim_metagenomics +synonym: "toxin anabolism" EXACT [] +synonym: "toxin biosynthesis" EXACT [] +synonym: "toxin formation" EXACT [] +synonym: "toxin synthesis" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0009404 +name: toxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] +subset: goslim_aspergillus +subset: goslim_pir +synonym: "toxin metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0009405 +name: obsolete pathogenesis +namespace: biological_process +def: "OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators] +comment: This term was obsoleted because it does not describe a single, normal biological process; rather it is the effect of an interaction between two organisms, under specific conditions. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_metagenomics +synonym: "virulence" RELATED [] +is_obsolete: true +consider: GO:0044003 +consider: GO:0052031 +consider: GO:0052042 + +[Term] +id: GO:0009406 +name: obsolete virulence +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a phenotype rather than a biological process. +synonym: "virulence" EXACT [] +is_obsolete: true +consider: GO:0016032 +consider: GO:0090729 + +[Term] +id: GO:0009407 +name: toxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] +synonym: "toxin breakdown" EXACT [] +synonym: "toxin catabolism" EXACT [] +synonym: "toxin degradation" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0098754 ! detoxification + +[Term] +id: GO:0009408 +name: response to heat +namespace: biological_process +alt_id: GO:0006951 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] +subset: goslim_yeast +synonym: "response to heat shock" NARROW [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0009409 +name: response to cold +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] +synonym: "freezing tolerance" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0009410 +name: response to xenobiotic stimulus +namespace: biological_process +alt_id: GO:0017035 +alt_id: GO:0017104 +alt_id: GO:0042493 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc] +subset: goslim_candida +synonym: "drug resistance" RELATED [] +synonym: "drug susceptibility/resistance" RELATED [] +synonym: "response to drug" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0009411 +name: response to UV +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] +synonym: "response to ultraviolet light stimulus" EXACT [] +synonym: "response to ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV light stimulus" EXACT [] +synonym: "response to UV radiation stimulus" EXACT [] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009412 +name: obsolete response to heavy metal +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "response to heavy metal" EXACT [] +is_obsolete: true +consider: GO:0010038 + +[Term] +id: GO:0009413 +name: response to flooding +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] +comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009414 +name: response to water deprivation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] +synonym: "drought tolerance" RELATED [] +synonym: "response to dehydration" EXACT [] +synonym: "response to drought" EXACT [] +synonym: "response to thirst" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0009415 +name: response to water +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] +synonym: "response to water stimulus" EXACT [GOC:dos] +is_a: GO:0001101 ! response to acid chemical +is_a: GO:0009628 ! response to abiotic stimulus +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0009416 +name: response to light stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] +subset: goslim_plant +is_a: GO:0009314 ! response to radiation + +[Term] +id: GO:0009417 +name: obsolete fimbrin +namespace: cellular_component +def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "fimbrin" EXACT [] +is_obsolete: true +replaced_by: GO:0009289 + +[Term] +id: GO:0009418 +name: pilus shaft +namespace: cellular_component +def: "The long, slender, mid section of a pilus." [GOC:jl] +synonym: "fimbrial shaft" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009289 ! pilus + +[Term] +id: GO:0009419 +name: pilus tip +namespace: cellular_component +def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl] +synonym: "fimbrial tip" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009289 ! pilus + +[Term] +id: GO:0009420 +name: bacterial-type flagellum filament +namespace: cellular_component +def: "The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar filament" EXACT [] +synonym: "flagellin-based flagellum filament" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009288 ! bacterial-type flagellum + +[Term] +id: GO:0009421 +name: bacterial-type flagellum filament cap +namespace: cellular_component +def: "The proteinaceous structure at the distal tip of the bacterial-type flagellar filament." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar filament cap" EXACT [] +synonym: "flagellin-based flagellum filament cap" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009420 ! bacterial-type flagellum filament + +[Term] +id: GO:0009422 +name: bacterial-type flagellum hook-filament junction +namespace: cellular_component +def: "The region of the bacterial-type flagellum where the hook and filament meet." [GOC:cilia, GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar hook-filament junction" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009288 ! bacterial-type flagellum + +[Term] +id: GO:0009423 +name: chorismate biosynthetic process +namespace: biological_process +alt_id: GO:0033587 +def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] +synonym: "chorismate anabolism" EXACT [] +synonym: "chorismate biosynthesis" EXACT [] +synonym: "chorismate formation" EXACT [] +synonym: "chorismate synthesis" EXACT [] +synonym: "shikimate anabolism" RELATED [] +synonym: "shikimate biosynthesis" RELATED [] +synonym: "shikimate biosynthetic process" RELATED [] +synonym: "shikimate pathway" EXACT [] +synonym: "shikimate synthesis" RELATED [] +xref: MetaCyc:ARO-PWY +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0009424 +name: bacterial-type flagellum hook +namespace: cellular_component +def: "The portion of the bacterial-type flagellum that connects the filament to the basal body." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar hook" EXACT [] +synonym: "flagellin-based flagellum hook" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009288 ! bacterial-type flagellum + +[Term] +id: GO:0009425 +name: bacterial-type flagellum basal body +namespace: cellular_component +def: "One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:24697492] +synonym: "flagellar basal body" BROAD [] +synonym: "flagellin-based flagellum basal body" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009288 ! bacterial-type flagellum + +[Term] +id: GO:0009426 +name: bacterial-type flagellum basal body, distal rod +namespace: cellular_component +def: "The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +synonym: "flagellar basal body, distal rod" EXACT [] +synonym: "flagellin-based flagellum basal body, distal rod" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod + +[Term] +id: GO:0009427 +name: bacterial-type flagellum basal body, distal rod, L ring +namespace: cellular_component +def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar basal body, distal rod, L ring" EXACT [] +synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod + +[Term] +id: GO:0009428 +name: bacterial-type flagellum basal body, distal rod, P ring +namespace: cellular_component +def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar basal body, distal rod, P ring" RELATED [] +synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod + +[Term] +id: GO:0009429 +name: bacterial-type flagellum basal body, proximal rod +namespace: cellular_component +def: "The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +synonym: "flagellar basal body, proximal rod" EXACT [] +synonym: "flagellin-based flagellum basal body, proximal rod" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod + +[Term] +id: GO:0009431 +name: bacterial-type flagellum basal body, MS ring +namespace: cellular_component +alt_id: GO:0009430 +def: "One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar basal body, mounting plate" BROAD [] +synonym: "flagellar basal body, MS ring" EXACT [] +synonym: "flagellin-based flagellum basal body, MS ring" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009425 ! bacterial-type flagellum basal body + +[Term] +id: GO:0009432 +name: SOS response +namespace: biological_process +def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023] +xref: Wikipedia:SOS_response +is_a: GO:0006974 ! cellular response to DNA damage stimulus +is_a: GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0009433 +name: bacterial-type flagellum basal body, C ring +namespace: cellular_component +def: "Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] +synonym: "flagellar basal body, C ring" EXACT [] +synonym: "flagellin-based flagellum basal body, C ring" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009425 ! bacterial-type flagellum basal body + +[Term] +id: GO:0009435 +name: NAD biosynthetic process +namespace: biological_process +alt_id: GO:0006736 +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] +synonym: "NAD (oxidized) biosynthesis" EXACT [] +synonym: "NAD (oxidized) biosynthetic process" EXACT [] +synonym: "NAD (reduced) biosynthesis" EXACT [] +synonym: "NAD (reduced) biosynthetic process" EXACT [] +synonym: "NAD anabolism" EXACT [] +synonym: "NAD biosynthesis" EXACT [] +synonym: "NAD formation" EXACT [] +synonym: "NAD synthesis" EXACT [] +synonym: "NADH biosynthesis" EXACT [] +synonym: "NADH biosynthetic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +synonym: "oxidized NAD biosynthesis" EXACT [] +synonym: "oxidized NAD biosynthetic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +synonym: "reduced NAD biosynthesis" EXACT [] +synonym: "reduced NAD biosynthetic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0009436 +name: glyoxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] +synonym: "glyoxylate breakdown" EXACT [] +synonym: "glyoxylate catabolism" EXACT [] +synonym: "glyoxylate degradation" EXACT [] +xref: MetaCyc:GLYOXDEG-PWY +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046487 ! glyoxylate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0009437 +name: carnitine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] +synonym: "carnitine metabolism" EXACT [] +synonym: "vitamin Bt metabolic process" EXACT [] +synonym: "vitamin Bt metabolism" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process + +[Term] +id: GO:0009438 +name: methylglyoxal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] +synonym: "methylglyoxal bypass" NARROW [] +synonym: "methylglyoxal metabolism" EXACT [] +synonym: "methylglyoxal pathway" NARROW [] +xref: MetaCyc:METHGLYUT-PWY +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0009439 +name: cyanate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] +synonym: "cyanate metabolism" EXACT [] +xref: MetaCyc:CYANCAT-PWY +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0009440 +name: cyanate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] +synonym: "cyanate breakdown" EXACT [] +synonym: "cyanate catabolism" EXACT [] +synonym: "cyanate degradation" EXACT [] +is_a: GO:0009439 ! cyanate metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0009441 +name: glycolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732] +synonym: "glycolate metabolism" EXACT [] +xref: MetaCyc:GLYCOLATEMET-PWY +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process + +[Term] +id: GO:0009442 +name: allantoin assimilation pathway +namespace: biological_process +def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] +synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] +synonym: "allantoin catabolism via ureidoglycolate" EXACT [] +synonym: "allantoin degradation pathway" RELATED [] +xref: MetaCyc:PWY0-41 +is_a: GO:0000256 ! allantoin catabolic process + +[Term] +id: GO:0009443 +name: pyridoxal 5'-phosphate salvage +namespace: biological_process +def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] +synonym: "pyridoxal 5' phosphate salvage" EXACT [] +xref: MetaCyc:PLPSAL-PWY +is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0009444 +name: pyruvate oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY] +xref: MetaCyc:PYRUVOX-PWY +xref: Wikipedia:Pyruvate_decarboxylation +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0009445 +name: putrescine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] +synonym: "putrescine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0009446 +name: putrescine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732] +synonym: "putrescine anabolism" EXACT [] +synonym: "putrescine biosynthesis" EXACT [] +synonym: "putrescine formation" EXACT [] +synonym: "putrescine synthesis" EXACT [] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0009445 ! putrescine metabolic process + +[Term] +id: GO:0009447 +name: putrescine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] +synonym: "putrescine breakdown" EXACT [] +synonym: "putrescine catabolism" EXACT [] +synonym: "putrescine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0009445 ! putrescine metabolic process + +[Term] +id: GO:0009448 +name: gamma-aminobutyric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] +comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. +synonym: "4-aminobutanoate metabolic process" EXACT [] +synonym: "4-aminobutanoate metabolism" EXACT [] +synonym: "4-aminobutyrate metabolic process" EXACT [] +synonym: "4-aminobutyrate metabolism" EXACT [] +synonym: "GABA metabolic process" EXACT [] +synonym: "GABA metabolism" EXACT [] +synonym: "gamma-aminobutyric acid metabolism" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009449 +name: gamma-aminobutyric acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] +comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. +synonym: "4-aminobutanoate biosynthesis" EXACT [] +synonym: "4-aminobutanoate biosynthetic process" EXACT [] +synonym: "4-aminobutyrate biosynthesis" EXACT [] +synonym: "4-aminobutyrate biosynthetic process" EXACT [] +synonym: "GABA biosynthesis" EXACT [] +synonym: "GABA biosynthetic process" EXACT [] +synonym: "gamma-aminobutyric acid anabolism" EXACT [] +synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] +synonym: "gamma-aminobutyric acid formation" EXACT [] +synonym: "gamma-aminobutyric acid synthesis" EXACT [] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process + +[Term] +id: GO:0009450 +name: gamma-aminobutyric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] +comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. +synonym: "4-aminobutanoate catabolic process" EXACT [] +synonym: "4-aminobutanoate catabolism" EXACT [] +synonym: "4-aminobutyrate catabolic process" EXACT [] +synonym: "4-aminobutyrate catabolism" EXACT [] +synonym: "GABA catabolic process" EXACT [] +synonym: "GABA catabolism" EXACT [] +synonym: "gamma-aminobutyric acid breakdown" EXACT [] +synonym: "gamma-aminobutyric acid catabolism" EXACT [] +synonym: "gamma-aminobutyric acid degradation" EXACT [] +xref: MetaCyc:4AMINOBUTMETAB-PWY +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process + +[Term] +id: GO:0009451 +name: RNA modification +namespace: biological_process +alt_id: GO:0016547 +def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. +subset: goslim_yeast +synonym: "RNA editing" NARROW [GOC:hjd] +xref: Wikipedia:RNA_editing +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0043412 ! macromolecule modification + +[Term] +id: GO:0009452 +name: 7-methylguanosine RNA capping +namespace: biological_process +def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript." [GOC:vw, PMID:9266685] +synonym: "m(7)G RNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] +synonym: "RNA capping" BROAD [GOC:krc, GOC:mah] +is_a: GO:0036260 ! RNA capping + +[Term] +id: GO:0009453 +name: energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] +synonym: "energytaxis" EXACT [] +synonym: "taxis in response to energy source" EXACT [] +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0009454 +name: aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] +synonym: "taxis in response to atmospheric oxygen" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0009455 +name: redox taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] +synonym: "redoxtaxis" EXACT [] +synonym: "taxis in response to redox potential" EXACT [] +synonym: "taxis in response to redox stimulus" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0009457 +name: obsolete flavodoxin +namespace: molecular_function +def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "flavodoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009458 +name: obsolete cytochrome +namespace: molecular_function +def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome" EXACT [] +is_obsolete: true +consider: GO:0004129 + +[Term] +id: GO:0009459 +name: obsolete cytochrome a +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome a" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009460 +name: obsolete cytochrome b +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome b" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009461 +name: obsolete cytochrome c +namespace: molecular_function +def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +is_obsolete: true +replaced_by: GO:0008121 + +[Term] +id: GO:0009462 +name: obsolete cytochrome d +namespace: molecular_function +def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome d" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009463 +name: obsolete cytochrome b/b6 +namespace: molecular_function +def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome b/b6" EXACT [] +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0009464 +name: obsolete cytochrome b5 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome b5" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009465 +name: obsolete soluble cytochrome b562 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "soluble cytochrome b562" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009466 +name: obsolete class I cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class I cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009467 +name: obsolete monoheme class I cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "monoheme class I cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009468 +name: obsolete diheme class I cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "diheme class I cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009469 +name: obsolete class II cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class II cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009470 +name: obsolete class IIa cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class IIa cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009471 +name: obsolete class III cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class III cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009472 +name: obsolete cytochrome c3 (tetraheme) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome c3 (tetraheme)" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009473 +name: obsolete cytochrome c7 (triheme) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome c7 (triheme)" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009474 +name: obsolete nonaheme cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "nonaheme cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009475 +name: obsolete high-molecular-weight cytochrome c (hexadecaheme) +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "high-molecular-weight cytochrome c (hexadecaheme)" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009476 +name: obsolete class IV cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class IV cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009477 +name: obsolete cytochrome c1 +namespace: molecular_function +def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome c1" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009478 +name: obsolete cytochrome c554 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome c554" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009479 +name: obsolete cytochrome f +namespace: molecular_function +def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome f" EXACT [] +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0009480 +name: obsolete class IIb cytochrome c +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "class IIb cytochrome c" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0009481 +name: obsolete aa3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +synonym: "aa3-type cytochrome c oxidase" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009482 +name: obsolete ba3-type cytochrome c oxidase +namespace: molecular_function +alt_id: GO:0009484 +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +synonym: "ba3-type cytochrome c oxidase" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009483 +name: obsolete caa3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +synonym: "caa3-type cytochrome c oxidase" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009485 +name: obsolete cbb3-type cytochrome c oxidase +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] +comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. +synonym: "cbb3-type cytochrome c oxidase" EXACT [] +is_obsolete: true +replaced_by: GO:0004129 + +[Term] +id: GO:0009486 +name: cytochrome bo3 ubiquinol oxidase activity +namespace: molecular_function +alt_id: GO:0008827 +def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [RHEA:30251] +synonym: "cytochrome bo oxidase" EXACT [EC:7.1.1.3] +synonym: "cytochrome bo(3) oxidase" EXACT [EC:7.1.1.3] +synonym: "cytochrome o ubiquinol oxidase activity" RELATED [] +xref: EC:7.1.1.3 +xref: MetaCyc:RXN0-5268 +xref: RHEA:30251 +xref: TC:3.D.4.5.1 +is_a: GO:0009055 ! electron transfer activity +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors + +[Term] +id: GO:0009487 +name: obsolete glutaredoxin +namespace: molecular_function +def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] +comment: This term was made obsolete because it represents a gene product. +synonym: "glutaredoxin" EXACT [] +is_obsolete: true +consider: GO:0003756 +consider: GO:0015036 +consider: GO:0015038 + +[Term] +id: GO:0009488 +name: obsolete amicyanin +namespace: molecular_function +def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "amicyanin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009489 +name: obsolete rubredoxin +namespace: molecular_function +def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "rubredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009490 +name: obsolete mononuclear iron electron carrier +namespace: molecular_function +def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "mononuclear iron electron carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009491 +name: obsolete redox-active disulfide bond electron carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "redox-active disulfide bond electron carrier" EXACT [] +synonym: "redox-active disulphide bond electron carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009492 +name: obsolete 2Fe-2S electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "2Fe-2S electron transfer carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009493 +name: obsolete adrenodoxin-type ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "adrenodoxin-type ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009494 +name: obsolete chloroplast-type ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "chloroplast-type ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009495 +name: obsolete thioredoxin-like 2Fe-2S ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "thioredoxin-like 2Fe-2S ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009496 +name: plastoquinol--plastocyanin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane." [RHEA:22148] +synonym: "cytochrome b6f" NARROW [] +synonym: "cytochrome b6f complex activity" RELATED [EC:7.1.1.6] +synonym: "plastoquinol-plastocyanin reductase activity" RELATED [] +synonym: "plastoquinol/plastocyanin oxidoreductase activity" RELATED [] +synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" RELATED [] +xref: EC:7.1.1.6 +xref: KEGG_REACTION:R03817 +xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN +xref: RHEA:22148 +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor + +[Term] +id: GO:0009497 +name: obsolete 3Fe-4S/4Fe-4S electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "3Fe-4S/4Fe-4S electron transfer carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009498 +name: obsolete bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "bacterial-type ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009499 +name: obsolete monocluster bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "monocluster bacterial-type ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009500 +name: obsolete dicluster bacterial-type ferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "dicluster bacterial-type ferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0009501 +name: amyloplast +namespace: cellular_component +def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] +xref: Wikipedia:Amyloplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009502 +name: obsolete photosynthetic electron transport chain +namespace: cellular_component +def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:0140514031] +comment: This term was made obsolete because it represents a process. +synonym: "photosynthetic electron transport chain" EXACT [] +is_obsolete: true +consider: GO:0009767 + +[Term] +id: GO:0009503 +name: thylakoid light-harvesting complex +namespace: cellular_component +def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684] +is_a: GO:0030076 ! light-harvesting complex +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex + +[Term] +id: GO:0009504 +name: cell plate +namespace: cellular_component +def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] +xref: Wikipedia:Cell_plate +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009505 +name: plant-type cell wall +namespace: cellular_component +def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208] +synonym: "cellulose and pectin-containing cell wall" EXACT [] +synonym: "plant cell wall" NARROW [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0009506 +name: plasmodesma +namespace: cellular_component +def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:29880547] +synonym: "plasmodesmata" EXACT [] +xref: Wikipedia:Plasmodesma +is_a: GO:0005911 ! cell-cell junction +relationship: part_of GO:0055044 ! symplast + +[Term] +id: GO:0009507 +name: chloroplast +namespace: cellular_component +def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] +subset: goslim_plant +xref: Wikipedia:Chloroplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009508 +name: plastid chromosome +namespace: cellular_component +def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943088399] +is_a: GO:0005694 ! chromosome +relationship: part_of GO:0042646 ! plastid nucleoid + +[Term] +id: GO:0009509 +name: chromoplast +namespace: cellular_component +def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] +xref: Wikipedia:Chromoplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009510 +name: plasmodesmatal desmotubule +namespace: cellular_component +alt_id: GO:0009572 +def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [PMID:29880547] +synonym: "desmotubule central rod" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005783 ! endoplasmic reticulum +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009511 +name: plasmodesmatal endoplasmic reticulum +namespace: cellular_component +def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai, PMID:29880547] +synonym: "plasmodesmatal ER" EXACT [] +is_a: GO:0005783 ! endoplasmic reticulum +relationship: part_of GO:0009510 ! plasmodesmatal desmotubule + +[Term] +id: GO:0009512 +name: cytochrome b6f complex +namespace: cellular_component +def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943088399, PMID:16228398, PMID:16352458] +synonym: "cyt b(6)f complex" EXACT [] +synonym: "cyt b6-f complex" EXACT [] +synonym: "cyt b6/f complex" EXACT [] +synonym: "cyt b6f complex" EXACT [] +synonym: "cytochrome b(6)f complex" EXACT [] +synonym: "cytochrome b6-f complex" EXACT [] +synonym: "cytochrome b6/f complex" EXACT [] +xref: Wikipedia:Cytochrome_b6f_complex +is_a: GO:0070069 ! cytochrome complex +relationship: part_of GO:0009579 ! thylakoid + +[Term] +id: GO:0009513 +name: etioplast +namespace: cellular_component +def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943088399] +xref: Wikipedia:Etioplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009514 +name: glyoxysome +namespace: cellular_component +def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031] +xref: Wikipedia:Glyoxysome +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0009515 +name: granal stacked thylakoid +namespace: cellular_component +def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] +synonym: "chloroplast stacked thylakoid" EXACT [] +is_a: GO:0009534 ! chloroplast thylakoid +relationship: part_of GO:0009542 ! granum + +[Term] +id: GO:0009516 +name: leucoplast +namespace: cellular_component +def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943088399] +xref: Wikipedia:Leucoplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009517 +name: PSII associated light-harvesting complex II +namespace: cellular_component +def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] +synonym: "LHCII" EXACT [] +is_a: GO:0009503 ! thylakoid light-harvesting complex + +[Term] +id: GO:0009518 +name: PSI associated light-harvesting complex I +namespace: cellular_component +def: "Protein-pigment complex associated with photosystem I." [GOC:lr] +synonym: "LHCI" EXACT [] +is_a: GO:0009503 ! thylakoid light-harvesting complex + +[Term] +id: GO:0009519 +name: middle lamella +namespace: cellular_component +def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] +xref: Wikipedia:Middle_lamella +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0009521 +name: photosystem +namespace: cellular_component +alt_id: GO:0030090 +def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] +subset: goslim_pir +synonym: "reaction center" NARROW [] +synonym: "reaction centre" NARROW [] +xref: Wikipedia:Photosystem +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0034357 ! photosynthetic membrane + +[Term] +id: GO:0009522 +name: photosystem I +namespace: cellular_component +def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] +is_a: GO:0009521 ! photosystem + +[Term] +id: GO:0009523 +name: photosystem II +namespace: cellular_component +def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] +xref: Wikipedia:Photosystem_II +is_a: GO:0009521 ! photosystem + +[Term] +id: GO:0009524 +name: phragmoplast +namespace: cellular_component +def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] +xref: Wikipedia:Phragmoplast +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009525 +name: phragmosome +namespace: cellular_component +def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943088399] +xref: Wikipedia:Phragmosome +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009526 +name: plastid envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] +is_a: GO:0031967 ! organelle envelope +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0009527 +name: plastid outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] +is_a: GO:0031968 ! organelle outer membrane +is_a: GO:0042170 ! plastid membrane + +[Term] +id: GO:0009528 +name: plastid inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] +is_a: GO:0019866 ! organelle inner membrane +is_a: GO:0042170 ! plastid membrane + +[Term] +id: GO:0009529 +name: plastid intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] +synonym: "plastid envelope lumen" EXACT [] +is_a: GO:0031970 ! organelle envelope lumen +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0009530 +name: primary cell wall +namespace: cellular_component +def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872] +is_a: GO:0009505 ! plant-type cell wall + +[Term] +id: GO:0009531 +name: secondary cell wall +namespace: cellular_component +def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399] +xref: Wikipedia:Secondary_cell_wall +is_a: GO:0009505 ! plant-type cell wall + +[Term] +id: GO:0009532 +name: plastid stroma +namespace: cellular_component +def: "The proteinaceous ground substance of plastids." [ISBN:0943088399] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0009533 +name: chloroplast stromal thylakoid +namespace: cellular_component +def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943088399] +is_a: GO:0009534 ! chloroplast thylakoid +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009534 +name: chloroplast thylakoid +namespace: cellular_component +def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399] +is_a: GO:0031976 ! plastid thylakoid +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0009535 +name: chloroplast thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0009534 ! chloroplast thylakoid + +[Term] +id: GO:0009536 +name: plastid +namespace: cellular_component +def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +xref: Wikipedia:Plastid +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0009537 +name: proplastid +namespace: cellular_component +def: "The precursor of other plastids." [ISBN:0943088399] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009538 +name: photosystem I reaction center +namespace: cellular_component +def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] +synonym: "photosystem I reaction centre" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009522 ! photosystem I + +[Term] +id: GO:0009539 +name: photosystem II reaction center +namespace: cellular_component +def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] +synonym: "photosystem II reaction centre" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009523 ! photosystem II + +[Term] +id: GO:0009541 +name: etioplast prolamellar body +namespace: cellular_component +def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0009542 +name: granum +namespace: cellular_component +def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:0140514031] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0009543 +name: chloroplast thylakoid lumen +namespace: cellular_component +def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943088399] +is_a: GO:0031978 ! plastid thylakoid lumen +relationship: part_of GO:0009534 ! chloroplast thylakoid + +[Term] +id: GO:0009544 +name: chloroplast ATP synthase complex +namespace: cellular_component +def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:0198547684] +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex + +[Term] +id: GO:0009545 +name: elaioplast +namespace: cellular_component +def: "A leucoplast in which oil is stored." [ISBN:0140514031] +xref: Wikipedia:Elaioplast +is_a: GO:0009516 ! leucoplast + +[Term] +id: GO:0009546 +name: plasmodesmatal cytoplasmic sleeve +namespace: cellular_component +def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [PMID:29880547] +synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009547 +name: plastid ribosome +namespace: cellular_component +def: "A ribosome contained within a plastid." [GOC:tair_curators] +is_a: GO:0000313 ! organellar ribosome +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0009548 +name: plasmodesmatal plasma membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0009506 ! plasmodesma + +[Term] +id: GO:0009549 +name: cellulose microfibril +namespace: cellular_component +def: "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009505 ! plant-type cell wall + +[Term] +id: GO:0009550 +name: primary plasmodesma +namespace: cellular_component +def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] +synonym: "simple plasmodesma" EXACT [] +is_a: GO:0009506 ! plasmodesma + +[Term] +id: GO:0009551 +name: secondary plasmodesma +namespace: cellular_component +def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] +is_a: GO:0009506 ! plasmodesma + +[Term] +id: GO:0009553 +name: embryo sac development +namespace: biological_process +alt_id: GO:0048230 +def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] +synonym: "female gametophyte development" EXACT [] +is_a: GO:0048229 ! gametophyte development + +[Term] +id: GO:0009554 +name: megasporogenesis +namespace: biological_process +def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] +synonym: "megaspore development" EXACT [] +synonym: "megaspore mother cell meiosis" EXACT [] +synonym: "meiosis of the megasporocyte" EXACT [] +synonym: "meiotic division of the megasporocyte" EXACT [] +is_a: GO:0048236 ! plant-type sporogenesis +relationship: part_of GO:0009553 ! embryo sac development + +[Term] +id: GO:0009555 +name: pollen development +namespace: biological_process +alt_id: GO:0009564 +alt_id: GO:0048231 +def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] +synonym: "formation of generative and vegetative cells" EXACT [] +synonym: "male gametophyte development" EXACT [] +synonym: "male gametophyte formation" EXACT [] +synonym: "microgametophyte development" EXACT [] +synonym: "pollen grain formation" EXACT [] +is_a: GO:0048229 ! gametophyte development + +[Term] +id: GO:0009556 +name: microsporogenesis +namespace: biological_process +def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] +synonym: "microspore development" EXACT systematic_synonym [] +is_a: GO:0048236 ! plant-type sporogenesis +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0009557 +name: antipodal cell differentiation +namespace: biological_process +def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009558 +name: embryo sac cellularization +namespace: biological_process +alt_id: GO:0009797 +def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] +synonym: "cellularization of the embryo sac" EXACT [] +synonym: "female gametophyte cellularization" EXACT [] +synonym: "megagametophyte cellularization" EXACT [] +is_a: GO:0007349 ! cellularization +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009559 +name: embryo sac central cell differentiation +namespace: biological_process +def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant] +synonym: "embryo sac endosperm mother cell differentiation" EXACT [] +synonym: "female gametophyte central cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009560 +name: embryo sac egg cell differentiation +namespace: biological_process +alt_id: GO:0048233 +def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu] +synonym: "female gamete generation" BROAD [] +synonym: "female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007292 ! female gamete generation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009561 +name: megagametogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] +synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] +synonym: "megagametophyte nucleus division" EXACT [] +xref: Wikipedia:Megagametogenesis +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0009553 ! embryo sac development + +[Term] +id: GO:0009562 +name: embryo sac nuclear migration +namespace: biological_process +def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] +synonym: "embryo sac nucleus migration" EXACT [] +synonym: "female gametophyte nuclear migration" EXACT [] +synonym: "female gametophyte nucleus migration" EXACT [] +synonym: "megagametophyte nuclear migration" EXACT [] +synonym: "megagametophyte nucleus migration" EXACT [] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009563 +name: synergid differentiation +namespace: biological_process +def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid] +synonym: "synergid cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0009566 +name: fertilization +namespace: biological_process +def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] +synonym: "syngamy" EXACT [] +xref: Wikipedia:Fertilisation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0019953 ! sexual reproduction + +[Term] +id: GO:0009567 +name: double fertilization forming a zygote and endosperm +namespace: biological_process +def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] +synonym: "double fertilization" EXACT [] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0009568 +name: amyloplast starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] +synonym: "amyloplast starch granule" EXACT [] +is_a: GO:0043036 ! starch grain +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0009569 +name: chloroplast starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732] +synonym: "chloroplast starch granule" EXACT [] +is_a: GO:0043036 ! starch grain +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0009570 +name: chloroplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0009571 +name: proplastid stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009537 ! proplastid + +[Term] +id: GO:0009573 +name: chloroplast ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu] +synonym: "chloroplast RubisCO complex" EXACT [] +is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009574 +name: preprophase band +namespace: cellular_component +def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732] +xref: Wikipedia:Preprophase_band +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0009575 +name: chromoplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009509 ! chromoplast + +[Term] +id: GO:0009576 +name: leucoplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009516 ! leucoplast + +[Term] +id: GO:0009577 +name: elaioplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009545 ! elaioplast + +[Term] +id: GO:0009578 +name: etioplast stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0009579 +name: thylakoid +namespace: cellular_component +def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] +comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "photosynthetic membrane" RELATED [] +xref: Wikipedia:Thylakoid +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0009580 +name: obsolete thylakoid (sensu Bacteria) +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific children exist. +synonym: "thylakoid (sensu Bacteria)" EXACT [] +is_obsolete: true +consider: GO:0030075 +consider: GO:0042716 + +[Term] +id: GO:0009581 +name: detection of external stimulus +namespace: biological_process +def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +synonym: "perception of external stimulus" RELATED [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009582 +name: detection of abiotic stimulus +namespace: biological_process +def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +synonym: "perception of abiotic stimulus" RELATED [] +is_a: GO:0009628 ! response to abiotic stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009583 +name: detection of light stimulus +namespace: biological_process +def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] +synonym: "detection of light" EXACT [] +synonym: "perception of light" RELATED [] +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0009584 +name: detection of visible light +namespace: biological_process +def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] +synonym: "perception of visible light" RELATED [] +is_a: GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0009585 +name: red, far-red light phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] +synonym: "phytochrome signaling pathway" BROAD [] +synonym: "red-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction +relationship: part_of GO:0010017 ! red or far-red light signaling pathway + +[Term] +id: GO:0009587 +name: obsolete phototrophin mediated phototransduction +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +synonym: "phototrophin mediated phototransduction" EXACT [] +is_obsolete: true +replaced_by: GO:0007602 + +[Term] +id: GO:0009588 +name: UV-A, blue light phototransduction +namespace: biological_process +def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah] +synonym: "blue-sensitive opsin" RELATED [] +synonym: "short-wave-sensitive opsin" RELATED [] +synonym: "violet-sensitive opsin" RELATED [] +is_a: GO:0007602 ! phototransduction + +[Term] +id: GO:0009589 +name: detection of UV +namespace: biological_process +def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] +synonym: "detection of ultraviolet light stimulus" EXACT [] +synonym: "detection of ultraviolet radiation stimulus" EXACT [] +synonym: "detection of UV light stimulus" EXACT [] +synonym: "detection of UV radiation stimulus" EXACT [] +synonym: "perception of UV" RELATED [] +is_a: GO:0009411 ! response to UV +is_a: GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0009590 +name: detection of gravity +namespace: biological_process +def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb] +synonym: "perception of gravity" RELATED [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0009629 ! response to gravity + +[Term] +id: GO:0009591 +name: obsolete perception of mechanical stimulus +namespace: biological_process +alt_id: GO:0007609 +def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] +comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. +synonym: "perception of mechanical stimulus" EXACT [] +is_obsolete: true +consider: GO:0050954 + +[Term] +id: GO:0009593 +name: detection of chemical stimulus +namespace: biological_process +def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] +synonym: "chemoperception" EXACT [] +synonym: "chemoreception" RELATED [] +synonym: "detection of chemical substance" EXACT [] +synonym: "perception of chemical stimulus" RELATED [] +synonym: "perception of chemical substance" RELATED [] +is_a: GO:0051606 ! detection of stimulus +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0009594 +name: detection of nutrient +namespace: biological_process +def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] +synonym: "detection of nutrients" EXACT [] +synonym: "nutrient sensing" RELATED [] +synonym: "perception of nutrients" RELATED [] +is_a: GO:0007584 ! response to nutrient +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0009595 +name: detection of biotic stimulus +namespace: biological_process +alt_id: GO:0009596 +def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] +synonym: "perception of biotic stimulus" RELATED [] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009597 +name: detection of virus +namespace: biological_process +def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] +comment: GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus. +synonym: "perception of virus" RELATED [] +is_a: GO:0009615 ! response to virus + +[Term] +id: GO:0009600 +name: detection of nematode +namespace: biological_process +def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] +synonym: "perception of nematode" RELATED [] +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0009601 +name: detection of insect +namespace: biological_process +def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] +synonym: "perception of insect" RELATED [] +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0009602 +name: detection of symbiont +namespace: biological_process +alt_id: GO:0051855 +def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] +synonym: "perception of symbiont" RELATED [] +synonym: "recognition of symbiont" EXACT [] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0051702 ! biological process involved in interaction with symbiont +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0009603 +name: detection of symbiotic fungus +namespace: biological_process +def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] +synonym: "detection of symbiotic fungi" EXACT [] +synonym: "perception of symbiotic fungi" RELATED [] +synonym: "perception of symbiotic fungus" RELATED [] +is_a: GO:0009602 ! detection of symbiont +is_a: GO:0009610 ! response to symbiotic fungus +is_a: GO:0016046 ! detection of fungus + +[Term] +id: GO:0009604 +name: detection of symbiotic bacterium +namespace: biological_process +def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] +synonym: "detection of symbiotic bacteria" EXACT [] +synonym: "perception of symbiotic bacteria" RELATED [] +synonym: "perception of symbiotic bacterium" RELATED [] +is_a: GO:0009602 ! detection of symbiont +is_a: GO:0009609 ! response to symbiotic bacterium +is_a: GO:0016045 ! detection of bacterium + +[Term] +id: GO:0009605 +name: response to external stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_drosophila +subset: goslim_plant +synonym: "response to environmental stimulus" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009606 +name: tropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088] +subset: goslim_plant +xref: Wikipedia:Tropism +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0009607 +name: response to biotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_metagenomics +subset: goslim_plant +synonym: "response to biotic stress" NARROW [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009608 +name: response to symbiont +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] +synonym: "response of host to symbiont" RELATED [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009609 +name: response to symbiotic bacterium +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732] +synonym: "response to symbiotic bacteria" EXACT [] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0009610 +name: response to symbiotic fungus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732] +synonym: "response to symbiotic fungi" EXACT [] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0009620 ! response to fungus + +[Term] +id: GO:0009611 +name: response to wounding +namespace: biological_process +alt_id: GO:0002245 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] +synonym: "physiological response to wounding" EXACT [] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0009612 +name: response to mechanical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] +synonym: "chemi-mechanical coupling" RELATED [] +synonym: "mechanical stimulus response" EXACT [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009614 +name: obsolete disease resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "disease resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0051707 + +[Term] +id: GO:0009615 +name: response to virus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] +synonym: "response to viruses" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009616 +name: RNAi-mediated antiviral immune response +namespace: biological_process +alt_id: GO:0060145 +alt_id: GO:0060150 +def: "RNA-mediated post-transcriptional gene silencing mechanism that protects against foreign organism invasion by restricting viral replication and dissemination." [GOC:jl, PMID:17693253, PMID:21724934, PMID:23686236, PMID:24732439, PMID:31100912] +comment: Virus induced gene silencing (VIGS) is used as a technique to control plant gene expression; when used in that context, this does not represent a normal biological process and is outside the scope of GO. +synonym: "RNAi-mediated antiviral immunity" EXACT [] +synonym: "VIGS" RELATED [] +synonym: "viral gene silencing in virus induced gene silencing" RELATED [] +synonym: "viral triggering of virus induced gene silencing" RELATED [] +synonym: "virus induced gene silencing" RELATED [] +synonym: "virus-induced gene silencing" EXACT [] +is_a: GO:0016441 ! posttranscriptional gene silencing +is_a: GO:0045087 ! innate immune response +is_a: GO:0051607 ! defense response to virus + +[Term] +id: GO:0009617 +name: response to bacterium +namespace: biological_process +alt_id: GO:0009618 +alt_id: GO:0009680 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] +synonym: "response to bacteria" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009619 +name: obsolete resistance to pathogenic bacteria +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "resistance to pathogenic bacteria" EXACT [] +is_obsolete: true +replaced_by: GO:0009617 + +[Term] +id: GO:0009620 +name: response to fungus +namespace: biological_process +alt_id: GO:0009621 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] +synonym: "response to fungi" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009622 +name: obsolete resistance to pathogenic fungi +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "resistance to pathogenic fungi" EXACT [] +is_obsolete: true +replaced_by: GO:0009620 + +[Term] +id: GO:0009624 +name: response to nematode +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] +synonym: "response to nematodes" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009625 +name: response to insect +namespace: biological_process +alt_id: GO:0043019 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] +synonym: "response to insects" EXACT [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0009626 +name: plant-type hypersensitive response +namespace: biological_process +def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] +comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. +synonym: "HR" BROAD [] +synonym: "HR-PCD" EXACT [] +synonym: "plant hypersensitive response" EXACT [] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0034050 ! programmed cell death induced by symbiont +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0009627 +name: systemic acquired resistance +namespace: biological_process +def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:0521436125] +synonym: "salicylic acid-dependent systemic resistance" EXACT [] +xref: Wikipedia:Systemic_acquired_resistance +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0009628 +name: response to abiotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_metagenomics +subset: goslim_plant +synonym: "response to abiotic stress" NARROW [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009629 +name: response to gravity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] +synonym: "response to gravitational stimulus" EXACT [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0009630 +name: gravitropism +namespace: biological_process +def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] +synonym: "geotropism" EXACT [] +xref: Wikipedia:Gravitropism +is_a: GO:0009606 ! tropism +is_a: GO:0009629 ! response to gravity + +[Term] +id: GO:0009631 +name: cold acclimation +namespace: biological_process +def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0009632 +name: obsolete freezing tolerance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. +synonym: "freezing tolerance" EXACT [] +is_obsolete: true +consider: GO:0009409 + +[Term] +id: GO:0009633 +name: obsolete drought tolerance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. +synonym: "drought tolerance" EXACT [] +is_obsolete: true +consider: GO:0009414 +consider: GO:0009819 + +[Term] +id: GO:0009634 +name: obsolete heavy metal sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "heavy metal sensitivity/resistance" EXACT [] +is_obsolete: true +consider: GO:0010038 + +[Term] +id: GO:0009635 +name: response to herbicide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators] +synonym: "herbicide susceptibility/resistance" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009636 ! response to toxic substance + +[Term] +id: GO:0009636 +name: response to toxic substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] +subset: goslim_chembl +synonym: "detoxification response" NARROW [] +synonym: "toxin resistance" RELATED [] +synonym: "toxin susceptibility/resistance" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0009637 +name: response to blue light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] +synonym: "response to blue light stimulus" EXACT [] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009638 +name: phototropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491] +xref: Wikipedia:Phototropism +is_a: GO:0009606 ! tropism +is_a: GO:0009637 ! response to blue light + +[Term] +id: GO:0009639 +name: response to red or far red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009640 +name: photomorphogenesis +namespace: biological_process +def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] +synonym: "plant development in response to light" EXACT systematic_synonym [] +xref: Wikipedia:Photomorphogenesis +is_a: GO:0009639 ! response to red or far red light +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009641 +name: shade avoidance +namespace: biological_process +def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance] +xref: Wikipedia:Shade_avoidance +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0009642 +name: response to light intensity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009643 +name: photosynthetic acclimation +namespace: biological_process +def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694] +synonym: "light acclimatization" EXACT [PMID:11069694] +synonym: "photoacclimation" EXACT [GOC:tb] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009644 +name: response to high light intensity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009645 +name: response to low light intensity stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009646 +name: response to absence of light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] +synonym: "response to darkness" RELATED [] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0009647 +name: skotomorphogenesis +namespace: biological_process +def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] +synonym: "etiolation" RELATED [] +is_a: GO:0009646 ! response to absence of light +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009648 +name: photoperiodism +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "response to day length" EXACT [] +synonym: "response to night length" EXACT [] +synonym: "response to photoperiod" EXACT [] +xref: Wikipedia:Photoperiodism +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0009649 +name: entrainment of circadian clock +namespace: biological_process +def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] +synonym: "regulation of circadian rhythm phase" RELATED [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0042752 ! regulation of circadian rhythm + +[Term] +id: GO:0009650 +name: UV protection +namespace: biological_process +def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] +synonym: "ultraviolet protection" EXACT [] +synonym: "ultraviolet resistance" RELATED [] +synonym: "ultraviolet tolerance" RELATED [] +synonym: "UV resistance" RELATED [] +synonym: "UV tolerance" RELATED [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0009651 +name: response to salt stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +synonym: "response to ionic osmotic stress" EXACT [] +synonym: "salinity response" EXACT [] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0009652 +name: thigmotropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165] +xref: Wikipedia:Thigmotropism +is_a: GO:0009606 ! tropism +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0009653 +name: anatomical structure morphogenesis +namespace: biological_process +def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] +synonym: "anatomical structure organization" EXACT [] +synonym: "embryogenesis and morphogenesis" BROAD [] +synonym: "morphogenesis" EXACT [] +xref: Wikipedia:Morphogenesis +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0048856 ! anatomical structure development + +[Term] +id: GO:0009654 +name: photosystem II oxygen evolving complex +namespace: cellular_component +def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [GOC:cjm, InterPro:IPR002683] +synonym: "OEC (PSII) complex" EXACT [GOC:cjm] +synonym: "oxygen evolving complex" EXACT [GOC:cjm] +xref: Wikipedia:Oxygen_evolving_complex +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0009523 ! photosystem II +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0009655 +name: PSII associated light-harvesting complex II, core complex +namespace: cellular_component +def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] +synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex +relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II + +[Term] +id: GO:0009656 +name: PSII associated light-harvesting complex II, peripheral complex +namespace: cellular_component +def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex +relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II + +[Term] +id: GO:0009657 +name: plastid organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] +subset: goslim_pir +synonym: "plastid organisation" EXACT [] +synonym: "plastid organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0009658 +name: chloroplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] +synonym: "chloroplast organisation" EXACT [] +synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009659 +name: leucoplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid] +synonym: "leucoplast organisation" EXACT [] +synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009660 +name: amyloplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid] +synonym: "amyloplast organisation" EXACT [] +synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009661 +name: chromoplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid] +synonym: "chromoplast organisation" EXACT [] +synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009662 +name: etioplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid] +synonym: "etioplast organisation" EXACT [] +synonym: "etioplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0009663 +name: plasmodesma organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah, PMID:29880547] +synonym: "plasmodesma organisation" EXACT [] +synonym: "plasmodesma organization and biogenesis" RELATED [] +synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0009664 +name: plant-type cell wall organization +namespace: biological_process +def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] +synonym: "cell wall organization and biogenesis" NARROW [] +synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah] +synonym: "plant-type cell wall organisation" EXACT [] +synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071555 ! cell wall organization +is_a: GO:0071669 ! plant-type cell wall organization or biogenesis + +[Term] +id: GO:0009665 +name: plastid inheritance +namespace: biological_process +def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] +is_a: GO:0009657 ! plastid organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0009666 +name: plastid outer membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid outer membrane organisation" EXACT [] +synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0009667 +name: plastid inner membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid inner membrane organisation" EXACT [] +synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0009668 +name: plastid membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "plastid membrane organisation" EXACT [] +synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0009657 ! plastid organization + +[Term] +id: GO:0009669 +name: sucrose:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] +synonym: "sucrose permease activity" RELATED [] +synonym: "sucrose:monovalent cation symporter activity" EXACT [] +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0008515 ! sucrose transmembrane transporter activity + +[Term] +id: GO:0009670 +name: triose-phosphate:phosphate antiporter activity +namespace: molecular_function +alt_id: GO:0015122 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] +synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] +synonym: "TPT" RELATED [] +synonym: "triose phosphate antiporter" EXACT [] +synonym: "triose phosphate translocator" EXACT [] +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity +is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity + +[Term] +id: GO:0009671 +name: nitrate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981] +synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] +synonym: "nitrate(chlorate):proton symporter activity" EXACT [] +synonym: "nitrate:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015296 ! anion:cation symporter activity +is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity + +[Term] +id: GO:0009672 +name: auxin:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] +synonym: "auxin:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0080161 ! auxin transmembrane transporter activity + +[Term] +id: GO:0009673 +name: low-affinity phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] +synonym: "low affinity phosphate transmembrane transporter activity" EXACT [] +is_a: GO:0015114 ! phosphate ion transmembrane transporter activity + +[Term] +id: GO:0009674 +name: potassium:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] +synonym: "high affinity potassium transporter" RELATED [] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0009675 +name: high-affinity sulfate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +synonym: "high affinity sulfate:hydrogen symporter activity" EXACT [] +synonym: "high affinity sulfate:proton symporter activity" EXACT [] +synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008512 ! sulfate:proton symporter activity + +[Term] +id: GO:0009676 +name: low-affinity sulfate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135] +synonym: "low affinity sulfate:hydrogen symporter activity" EXACT [] +synonym: "low affinity sulfate:proton symporter activity" EXACT [] +synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] +is_a: GO:0008512 ! sulfate:proton symporter activity + +[Term] +id: GO:0009677 +name: double fertilization forming two zygotes +namespace: biological_process +def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb] +is_a: GO:0009566 ! fertilization + +[Term] +id: GO:0009678 +name: pyrophosphate hydrolysis-driven proton transmembrane transporter activity +namespace: molecular_function +def: "Enables the transmembrane transport of one proton (H+), driven by the hydrolysis of pyrophosphate, and generating a proton motive force." [GOC:mtg_transport, ISBN:0815340729, Wikipedia:Proton-pumping_pyrophosphatase] +synonym: "diphosphate hydrolysis-driven proton transmembrane transporter activity" EXACT [] +synonym: "H(+)-exporting diphosphatase" RELATED [EC:7.1.3.1] +synonym: "hydrogen-translocating pyrophosphatase activity" RELATED [EC:7.1.3.1] +synonym: "PP(i) hydrolysis-driven proton transmembrane transporter activity" EXACT [] +synonym: "proton-pumping diphosphatase" RELATED [EC:7.1.3.1] +synonym: "proton-pumping pyrophosphatase" RELATED [EC:7.1.3.1] +synonym: "proton-translocating pyrophosphatase activity" EXACT [] +xref: EC:7.1.3.1 +xref: MetaCyc:TRANS-RXN-370 +xref: RHEA:13973 +xref: TC:3.A.10 +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015399 ! primary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0009679 +name: hexose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] +synonym: "hexose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0009682 +name: induced systemic resistance +namespace: biological_process +def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] +is_a: GO:0042742 ! defense response to bacterium +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0009683 +name: indoleacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] +synonym: "IAA metabolic process" EXACT [] +synonym: "indole acetic acid metabolic process" EXACT [] +synonym: "indole acetic acid metabolism" EXACT [] +synonym: "indoleacetic acid metabolism" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:0009684 +name: indoleacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] +synonym: "IAA biosynthetic process" EXACT [] +synonym: "indole acetic acid biosynthesis" EXACT [] +synonym: "indole acetic acid biosynthetic process" EXACT [] +synonym: "indole-3-acetate biosynthesis" EXACT [] +synonym: "indole-3-acetate biosynthetic process" EXACT [] +synonym: "indole-acetic acid biosynthesis" EXACT [] +synonym: "indole-acetic acid biosynthetic process" RELATED [] +synonym: "indoleacetic acid anabolism" EXACT [] +synonym: "indoleacetic acid biosynthesis" EXACT [] +synonym: "indoleacetic acid formation" EXACT [] +synonym: "indoleacetic acid synthesis" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process +is_a: GO:0009851 ! auxin biosynthetic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0009685 +name: gibberellin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] +synonym: "gibberellic acid metabolic process" NARROW [] +synonym: "gibberellic acid metabolism" NARROW [] +synonym: "gibberellin metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0016101 ! diterpenoid metabolic process + +[Term] +id: GO:0009686 +name: gibberellin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] +synonym: "gibberellic acid anabolism" NARROW [] +synonym: "gibberellic acid biosynthesis" NARROW [] +synonym: "gibberellic acid biosynthetic process" NARROW [] +synonym: "gibberellic acid formation" NARROW [] +synonym: "gibberellic acid synthesis" NARROW [] +synonym: "gibberellin biosynthesis" EXACT [] +xref: MetaCyc:PWY-5035 +xref: MetaCyc:PWY-5036 +xref: MetaCyc:PWY-5052 +xref: MetaCyc:PWY-5070 +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0016102 ! diterpenoid biosynthetic process + +[Term] +id: GO:0009687 +name: abscisic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] +synonym: "abscisic acid metabolism" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043288 ! apocarotenoid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:0009688 +name: abscisic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] +synonym: "abscisic acid anabolism" EXACT [] +synonym: "abscisic acid biosynthesis" EXACT [] +synonym: "abscisic acid formation" EXACT [] +synonym: "abscisic acid synthesis" EXACT [] +xref: MetaCyc:PWY-695 +is_a: GO:0009687 ! abscisic acid metabolic process +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0043289 ! apocarotenoid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:0009689 +name: induction of phytoalexin biosynthetic process +namespace: biological_process +def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] +synonym: "induction of phytoalexin anabolism" EXACT [] +synonym: "induction of phytoalexin biosynthesis" EXACT [] +synonym: "induction of phytoalexin formation" EXACT [] +synonym: "induction of phytoalexin synthesis" EXACT [] +is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0009690 +name: cytokinin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] +subset: goslim_chembl +synonym: "cytokinin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0009691 +name: cytokinin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] +synonym: "cytokinin anabolism" EXACT [] +synonym: "cytokinin biosynthesis" EXACT [] +synonym: "cytokinin formation" EXACT [] +synonym: "cytokinin synthesis" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0009692 +name: ethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] +synonym: "ethene metabolic process" EXACT [] +synonym: "ethene metabolism" EXACT [] +synonym: "ethylene metabolism" EXACT [] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0009693 +name: ethylene biosynthetic process +namespace: biological_process +alt_id: GO:0042456 +def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] +synonym: "ethene biosynthesis" EXACT [] +synonym: "ethene biosynthesis from L-methionine" EXACT [] +synonym: "ethene biosynthetic process" EXACT [] +synonym: "ethene biosynthetic process from L-methionine" EXACT [] +synonym: "ethylene anabolism" EXACT [] +synonym: "ethylene biosynthesis" EXACT [] +synonym: "ethylene biosynthesis from L-methionine" EXACT [] +synonym: "ethylene biosynthetic process from L-methionine" EXACT [] +synonym: "ethylene formation" EXACT [] +synonym: "ethylene synthesis" EXACT [] +xref: MetaCyc:ETHYL-PWY +is_a: GO:0009692 ! ethylene metabolic process +is_a: GO:0043450 ! alkene biosynthetic process + +[Term] +id: GO:0009694 +name: jasmonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] +synonym: "jasmonic acid metabolism" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0009695 +name: jasmonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] +synonym: "jasmonic acid anabolism" EXACT [] +synonym: "jasmonic acid biosynthesis" EXACT [] +synonym: "jasmonic acid formation" EXACT [] +synonym: "jasmonic acid synthesis" EXACT [] +xref: MetaCyc:PWY-735 +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0009694 ! jasmonic acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0009696 +name: salicylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] +synonym: "salicylic acid metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0009697 +name: salicylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] +synonym: "salicylate biosynthetic process" EXACT [] +synonym: "salicylic acid anabolism" EXACT [] +synonym: "salicylic acid biosynthesis" EXACT [] +synonym: "salicylic acid formation" EXACT [] +synonym: "salicylic acid synthesis" EXACT [] +xref: MetaCyc:PWY-981 +is_a: GO:0009696 ! salicylic acid metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0009698 +name: phenylpropanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] +synonym: "phenylpropanoid metabolism" EXACT [] +xref: MetaCyc:PWY1F-467 +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0009699 +name: phenylpropanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] +synonym: "phenylpropanoid anabolism" EXACT [] +synonym: "phenylpropanoid biosynthesis" EXACT [] +synonym: "phenylpropanoid formation" EXACT [] +synonym: "phenylpropanoid synthesis" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0009700 +name: indole phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] +synonym: "indole phytoalexin anabolism" EXACT [] +synonym: "indole phytoalexin biosynthesis" EXACT [] +synonym: "indole phytoalexin formation" EXACT [] +synonym: "indole phytoalexin synthesis" EXACT [] +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0046217 ! indole phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0009701 +name: isoflavonoid phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +synonym: "isoflavonoid phytoalexin anabolism" EXACT [] +synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] +synonym: "isoflavonoid phytoalexin formation" EXACT [] +synonym: "isoflavonoid phytoalexin synthesis" EXACT [] +is_a: GO:0009717 ! isoflavonoid biosynthetic process +is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0009702 +name: L-arabinokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.46, RHEA:20153] +synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] +synonym: "L-arabinokinase (phosphorylating)" RELATED [EC:2.7.1.46] +xref: EC:2.7.1.46 +xref: KEGG_REACTION:R01754 +xref: MetaCyc:L-ARABINOKINASE-RXN +xref: RHEA:20153 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0009703 +name: nitrate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1] +comment: Note that this function was formerly EC:1.6.6.1. +synonym: "assimilatory NADH: nitrate reductase activity" RELATED [EC:1.7.1.1] +synonym: "assimilatory NADH:nitrate reductase activity" RELATED [EC:1.7.1.1] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] +synonym: "NADH-dependent nitrate reductase activity" RELATED [EC:1.7.1.1] +synonym: "NADH-nitrate reductase activity" RELATED [EC:1.7.1.1] +synonym: "NADH:nitrate oxidoreductase activity" RELATED [EC:1.7.1.1] +synonym: "NADH:nitrate reductase activity" EXACT [] +synonym: "nitrate reductase (NADH(2)) activity" RELATED [EC:1.7.1.1] +synonym: "nitrate reductase (NADH2)" RELATED [EC:1.7.1.1] +synonym: "nitrite:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.1] +xref: EC:1.7.1.1 +xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN +xref: RHEA:17913 +is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity + +[Term] +id: GO:0009704 +name: de-etiolation +namespace: biological_process +def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] +is_a: GO:0009416 ! response to light stimulus +relationship: part_of GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0009705 +name: plant-type vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208] +synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] +synonym: "tonoplast" EXACT [] +synonym: "vacuolar membrane" BROAD [] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0009706 +name: chloroplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] +synonym: "chloroplast inner envelope" EXACT [] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0031969 ! chloroplast membrane + +[Term] +id: GO:0009707 +name: chloroplast outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] +synonym: "chloroplast outer envelope" EXACT [] +is_a: GO:0009527 ! plastid outer membrane +is_a: GO:0031969 ! chloroplast membrane + +[Term] +id: GO:0009708 +name: benzyl isoquinoline alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732] +synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] +synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] +synonym: "benzyl isoquinoline alkaloid formation" EXACT [] +synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] +is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process +is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process + +[Term] +id: GO:0009709 +name: terpenoid indole alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] +synonym: "terpenoid indole alkaloid anabolism" EXACT [] +synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] +synonym: "terpenoid indole alkaloid formation" EXACT [] +synonym: "terpenoid indole alkaloid synthesis" EXACT [] +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process + +[Term] +id: GO:0009710 +name: tropane alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732] +synonym: "tropane alkaloid anabolism" EXACT [] +synonym: "tropane alkaloid biosynthesis" EXACT [] +synonym: "tropane alkaloid formation" EXACT [] +synonym: "tropane alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046448 ! tropane alkaloid metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0009711 +name: purine alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] +synonym: "purine alkaloid anabolism" EXACT [] +synonym: "purine alkaloid biosynthesis" EXACT [] +synonym: "purine alkaloid formation" EXACT [] +synonym: "purine alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0046446 ! purine alkaloid metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0009712 +name: catechol-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] +synonym: "catechol metabolic process" RELATED [] +synonym: "catechol metabolism" RELATED [] +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0009713 +name: catechol-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +synonym: "catechol anabolism" RELATED [] +synonym: "catechol biosynthesis" RELATED [] +synonym: "catechol biosynthetic process" RELATED [] +synonym: "catechol formation" RELATED [] +synonym: "catechol synthesis" RELATED [] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0009714 +name: chalcone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732] +synonym: "chalcone metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0009715 +name: chalcone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] +synonym: "chalcone anabolism" EXACT [] +synonym: "chalcone biosynthesis" EXACT [] +synonym: "chalcone formation" EXACT [] +synonym: "chalcone synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009714 ! chalcone metabolic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:0009716 +name: flavonoid phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] +synonym: "flavonoid phytoalexin anabolism" EXACT [] +synonym: "flavonoid phytoalexin biosynthesis" EXACT [] +synonym: "flavonoid phytoalexin formation" EXACT [] +synonym: "flavonoid phytoalexin synthesis" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046285 ! flavonoid phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0009717 +name: isoflavonoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] +synonym: "isoflavonoid anabolism" EXACT [] +synonym: "isoflavonoid biosynthesis" EXACT [] +synonym: "isoflavonoid formation" EXACT [] +synonym: "isoflavonoid synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046287 ! isoflavonoid metabolic process + +[Term] +id: GO:0009718 +name: anthocyanin-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] +synonym: "anthocyanin anabolism" EXACT [] +synonym: "anthocyanin biosynthesis" EXACT [] +synonym: "anthocyanin biosynthetic process" EXACT [] +synonym: "anthocyanin formation" EXACT [] +synonym: "anthocyanin synthesis" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0046283 ! anthocyanin-containing compound metabolic process + +[Term] +id: GO:0009719 +name: response to endogenous stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_plant +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0009720 +name: detection of hormone stimulus +namespace: biological_process +def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of hormone stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009725 ! response to hormone +is_a: GO:0009726 ! detection of endogenous stimulus + +[Term] +id: GO:0009721 +name: detection of auxin stimulus +namespace: biological_process +def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of auxin stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009733 ! response to auxin + +[Term] +id: GO:0009722 +name: detection of cytokinin stimulus +namespace: biological_process +def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of cytokinin stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009735 ! response to cytokinin + +[Term] +id: GO:0009723 +name: response to ethylene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] +synonym: "response to ethene stimulus" EXACT [] +synonym: "response to ethylene stimulus" EXACT [] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0009724 +name: detection of abscisic acid stimulus +namespace: biological_process +def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of abscisic acid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009737 ! response to abscisic acid + +[Term] +id: GO:0009725 +name: response to hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] +synonym: "growth regulator" RELATED [] +synonym: "response to hormone stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0009726 +name: detection of endogenous stimulus +namespace: biological_process +def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of endogenous stimulus" RELATED [] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0009727 +name: detection of ethylene stimulus +namespace: biological_process +def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "detection of ethene stimulus" EXACT [] +synonym: "perception of ethene stimulus" RELATED [] +synonym: "perception of ethylene stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009723 ! response to ethylene + +[Term] +id: GO:0009728 +name: detection of gibberellic acid stimulus +namespace: biological_process +def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of gibberellic acid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009739 ! response to gibberellin + +[Term] +id: GO:0009729 +name: detection of brassinosteroid stimulus +namespace: biological_process +def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of brassinosteroid stimulus" RELATED [] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0009741 ! response to brassinosteroid + +[Term] +id: GO:0009730 +name: detection of carbohydrate stimulus +namespace: biological_process +def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of carbohydrate stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0009731 +name: detection of sucrose stimulus +namespace: biological_process +def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of sucrose stimulus" RELATED [] +is_a: GO:0009744 ! response to sucrose +is_a: GO:0034288 ! detection of disaccharide stimulus + +[Term] +id: GO:0009732 +name: detection of hexose stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] +synonym: "perception of hexose stimulus" RELATED [] +is_a: GO:0009746 ! response to hexose +is_a: GO:0034287 ! detection of monosaccharide stimulus + +[Term] +id: GO:0009733 +name: response to auxin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] +synonym: "response to auxin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0009734 +name: auxin-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826] +synonym: "auxin mediated signaling pathway" RELATED [] +synonym: "auxin mediated signalling" EXACT [] +synonym: "auxin signal transduction" EXACT [PMID:16990790] +synonym: "auxin signaling" EXACT [PMID:18647826] +synonym: "auxin-regulated transcription" RELATED [PMID:15917797] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071365 ! cellular response to auxin stimulus + +[Term] +id: GO:0009735 +name: response to cytokinin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] +synonym: "response to cytokinin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0009736 +name: cytokinin-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:sm, PMID:24080474] +synonym: "cytokinin mediated signaling pathway" RELATED [] +synonym: "cytokinin mediated signalling" EXACT [] +synonym: "cytokinin signaling" EXACT [PMID:24080474] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071368 ! cellular response to cytokinin stimulus + +[Term] +id: GO:0009737 +name: response to abscisic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] +synonym: "response to abscisic acid stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0009738 +name: abscisic acid-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription." [GOC:signaling, GOC:sm, PMID:24269821] +synonym: "ABA signal transduction" EXACT [PMID:20713515] +synonym: "ABA signaling" EXACT [PMID:24269821] +synonym: "abscisic acid mediated signalling" EXACT [] +synonym: "abscisic acid signal transduction" RELATED [PMID:20713515] +synonym: "abscisic acid-mediated signaling pathway" RELATED [] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071215 ! cellular response to abscisic acid stimulus + +[Term] +id: GO:0009739 +name: response to gibberellin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] +synonym: "response to gibberellic acid stimulus" NARROW [] +synonym: "response to gibberellin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0009740 +name: gibberellic acid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] +synonym: "GA-signaling" EXACT [] +synonym: "gibberellic acid mediated signalling" EXACT [] +synonym: "gibberellic acid signaling" EXACT [] +is_a: GO:0010476 ! gibberellin mediated signaling pathway + +[Term] +id: GO:0009741 +name: response to brassinosteroid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] +synonym: "response to brassinosteroid stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0009742 +name: brassinosteroid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] +synonym: "brassinosteroid mediated signalling" EXACT [] +is_a: GO:0043401 ! steroid hormone mediated signaling pathway +relationship: part_of GO:0071367 ! cellular response to brassinosteroid stimulus + +[Term] +id: GO:0009743 +name: response to carbohydrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] +synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0009744 +name: response to sucrose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] +synonym: "response to sucrose stimulus" EXACT [GOC:dos] +is_a: GO:0034285 ! response to disaccharide + +[Term] +id: GO:0009745 +name: sucrose mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] +synonym: "sucrose mediated signalling" EXACT [] +is_a: GO:0010182 ! sugar mediated signaling pathway +relationship: part_of GO:0071329 ! cellular response to sucrose stimulus + +[Term] +id: GO:0009746 +name: response to hexose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] +synonym: "response to hexose stimulus" EXACT [GOC:dos] +is_a: GO:0034284 ! response to monosaccharide + +[Term] +id: GO:0009747 +name: hexokinase-dependent signaling +namespace: biological_process +def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] +synonym: "hexokinase-dependent signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling + +[Term] +id: GO:0009748 +name: hexokinase-independent signaling +namespace: biological_process +def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] +synonym: "hexokinase-independent signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling + +[Term] +id: GO:0009749 +name: response to glucose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] +synonym: "response to glucose stimulus" EXACT [GOC:dos] +is_a: GO:0009746 ! response to hexose + +[Term] +id: GO:0009750 +name: response to fructose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] +synonym: "response to fructose stimulus" EXACT [GOC:dos] +is_a: GO:0009746 ! response to hexose + +[Term] +id: GO:0009751 +name: response to salicylic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] +synonym: "response to salicylate" EXACT [GOC:dph] +synonym: "response to salicylic acid stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0009752 +name: detection of salicylic acid stimulus +namespace: biological_process +def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "perception of salicylic acid stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009751 ! response to salicylic acid + +[Term] +id: GO:0009753 +name: response to jasmonic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] +synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:0009754 +name: detection of jasmonic acid stimulus +namespace: biological_process +def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] +synonym: "perception of jasmonic acid stimulus" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0009726 ! detection of endogenous stimulus +is_a: GO:0009753 ! response to jasmonic acid + +[Term] +id: GO:0009755 +name: hormone-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] +synonym: "hormone mediated signalling" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0032870 ! cellular response to hormone stimulus + +[Term] +id: GO:0009756 +name: carbohydrate mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] +synonym: "carbohydrate mediated signalling" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0071322 ! cellular response to carbohydrate stimulus + +[Term] +id: GO:0009757 +name: hexose mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] +synonym: "hexose mediated signalling" EXACT [] +is_a: GO:0010182 ! sugar mediated signaling pathway +relationship: part_of GO:0071331 ! cellular response to hexose stimulus + +[Term] +id: GO:0009758 +name: carbohydrate utilization +namespace: biological_process +alt_id: GO:0007587 +def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg] +synonym: "sugar utilization" NARROW [GOC:mcc2] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0009759 +name: indole glucosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] +synonym: "indole glucosinolate anabolism" EXACT [] +synonym: "indole glucosinolate biosynthesis" EXACT [] +synonym: "indole glucosinolate formation" EXACT [] +synonym: "indole glucosinolate synthesis" EXACT [] +is_a: GO:0019761 ! glucosinolate biosynthetic process +is_a: GO:0042343 ! indole glucosinolate metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process + +[Term] +id: GO:0009760 +name: C4 photosynthesis +namespace: biological_process +def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] +xref: Wikipedia:C4_carbon_fixation +is_a: GO:0015977 ! carbon fixation +is_a: GO:0019685 ! photosynthesis, dark reaction + +[Term] +id: GO:0009761 +name: CAM photosynthesis +namespace: biological_process +def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] +xref: Wikipedia:Crassulacean_acid_metabolism +is_a: GO:0015977 ! carbon fixation +is_a: GO:0019685 ! photosynthesis, dark reaction + +[Term] +id: GO:0009762 +name: NADP-malic enzyme C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] +xref: MetaCyc:PWY-241 +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009763 +name: NAD-malic enzyme C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009764 +name: PEP carboxykinase C4 photosynthesis +namespace: biological_process +def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] +is_a: GO:0009760 ! C4 photosynthesis + +[Term] +id: GO:0009765 +name: photosynthesis, light harvesting +namespace: biological_process +def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] +synonym: "energy dissipation" RELATED [] +is_a: GO:0006091 ! generation of precursor metabolites and energy +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009766 +name: obsolete primary charge separation +namespace: biological_process +def: "OBSOLETE. In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] +comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO. +is_obsolete: true + +[Term] +id: GO:0009767 +name: photosynthetic electron transport chain +namespace: biological_process +alt_id: GO:0009774 +alt_id: GO:0009775 +alt_id: GO:0009776 +def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] +synonym: "electron carrier, chlorophyll electron transport system" EXACT [] +synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW [] +synonym: "photosynthetic electron transport in plastocyanin" NARROW [] +synonym: "photosynthetic electron transport in plastoquinone" NARROW [] +is_a: GO:0022900 ! electron transport chain +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009768 +name: photosynthesis, light harvesting in photosystem I +namespace: biological_process +def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0009769 +name: photosynthesis, light harvesting in photosystem II +namespace: biological_process +def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0009770 +name: obsolete primary charge separation in photosystem I +namespace: biological_process +def: "OBSOLETE. Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO. +is_obsolete: true + +[Term] +id: GO:0009771 +name: obsolete primary charge separation in photosystem II +namespace: biological_process +def: "OBSOLETE. Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +comment: This term was obsoleted because it represents a mechanism, and is outside the scope of GO. +is_obsolete: true + +[Term] +id: GO:0009772 +name: photosynthetic electron transport in photosystem II +namespace: biological_process +def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009773 +name: photosynthetic electron transport in photosystem I +namespace: biological_process +def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360] +is_a: GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0009777 +name: photosynthetic phosphorylation +namespace: biological_process +def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] +synonym: "photosynthetic ATP synthesis" NARROW [] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0046034 ! ATP metabolic process +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009778 +name: cyclic photosynthetic phosphorylation +namespace: biological_process +def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] +is_a: GO:0009777 ! photosynthetic phosphorylation + +[Term] +id: GO:0009779 +name: noncyclic photosynthetic phosphorylation +namespace: biological_process +def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] +is_a: GO:0009777 ! photosynthetic phosphorylation + +[Term] +id: GO:0009780 +name: photosynthetic NADP+ reduction +namespace: biological_process +def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360] +is_a: GO:0006740 ! NADPH regeneration +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0009781 +name: obsolete photosynthetic water oxidation +namespace: biological_process +def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360] +comment: This term was made obsolete because it represents a molecular function. +synonym: "photosynthetic water oxidation" EXACT [] +is_obsolete: true +replaced_by: GO:0010242 + +[Term] +id: GO:0009782 +name: photosystem I antenna complex +namespace: cellular_component +def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009522 ! photosystem I + +[Term] +id: GO:0009783 +name: photosystem II antenna complex +namespace: cellular_component +def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009523 ! photosystem II + +[Term] +id: GO:0009784 +name: transmembrane receptor histidine kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] +is_a: GO:0004673 ! protein histidine kinase activity +is_a: GO:0019199 ! transmembrane receptor protein kinase activity + +[Term] +id: GO:0009785 +name: blue light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] +synonym: "blue light signalling pathway" EXACT [] +is_a: GO:0030522 ! intracellular receptor signaling pathway +is_a: GO:0071483 ! cellular response to blue light + +[Term] +id: GO:0009786 +name: regulation of asymmetric cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0009787 +name: regulation of abscisic acid-activated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] +synonym: "regulation of abscisic acid mediated signaling pathway" RELATED [] +synonym: "regulation of abscisic acid mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:1905957 ! regulation of cellular response to alcohol +relationship: regulates GO:0009738 ! abscisic acid-activated signaling pathway + +[Term] +id: GO:0009788 +name: negative regulation of abscisic acid-activated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] +synonym: "down regulation of abscisic acid mediated signaling" EXACT [] +synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] +synonym: "downregulation of abscisic acid mediated signaling" EXACT [] +synonym: "inhibition of abscisic acid mediated signaling" NARROW [] +synonym: "negative regulation of abscisic acid mediated signaling pathway" RELATED [] +synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] +is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1905958 ! negative regulation of cellular response to alcohol +relationship: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway + +[Term] +id: GO:0009789 +name: positive regulation of abscisic acid-activated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] +synonym: "activation of abscisic acid mediated signaling" NARROW [] +synonym: "positive regulation of abscisic acid mediated signaling pathway" RELATED [] +synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] +synonym: "stimulation of abscisic acid mediated signaling" NARROW [] +synonym: "up regulation of abscisic acid mediated signaling" EXACT [] +synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] +synonym: "upregulation of abscisic acid mediated signaling" EXACT [] +is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway + +[Term] +id: GO:0009790 +name: embryo development +namespace: biological_process +alt_id: GO:0009795 +def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] +subset: gocheck_do_not_manually_annotate +subset: goslim_chembl +subset: goslim_plant +synonym: "embryogenesis" EXACT [] +synonym: "embryogenesis and morphogenesis" BROAD [] +synonym: "embryonal development" EXACT [] +xref: Wikipedia:Embryogenesis +is_a: GO:0007275 ! multicellular organism development + +[Term] +id: GO:0009791 +name: post-embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] +subset: goslim_plant +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0009792 +name: embryo development ending in birth or egg hatching +namespace: biological_process +def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] +synonym: "embryogenesis" BROAD [] +is_a: GO:0009790 ! embryo development + +[Term] +id: GO:0009793 +name: embryo development ending in seed dormancy +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu] +synonym: "embryogenesis" BROAD [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009790 ! embryo development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0009794 +name: regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "embryonic mitotic cell cycle modulation" EXACT [] +synonym: "embryonic mitotic cell cycle regulation" EXACT [] +synonym: "embryonic mitotic cell cycle regulator" RELATED [] +synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0009798 +name: axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "axis determination" RELATED [] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0009799 +name: specification of symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] +synonym: "determination of symmetry" EXACT [GOC:dph] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0009800 +name: cinnamic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] +synonym: "cinnamic acid anabolism" EXACT [] +synonym: "cinnamic acid biosynthesis" EXACT [] +synonym: "cinnamic acid formation" EXACT [] +synonym: "cinnamic acid synthesis" EXACT [] +synonym: "cinnamylic acid biosynthesis" EXACT [] +synonym: "cinnamylic acid biosynthetic process" EXACT [] +synonym: "phenylacrylic acid biosynthesis" EXACT [] +synonym: "phenylacrylic acid biosynthetic process" EXACT [] +synonym: "phenylpropenoic acid biosynthesis" EXACT [] +synonym: "phenylpropenoic acid biosynthetic process" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009803 ! cinnamic acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:0009801 +name: cinnamic acid ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] +synonym: "cinnamic acid ester metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0009802 +name: cinnamic acid ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] +synonym: "cinnamic acid ester anabolism" EXACT [] +synonym: "cinnamic acid ester biosynthesis" EXACT [] +synonym: "cinnamic acid ester formation" EXACT [] +synonym: "cinnamic acid ester synthesis" EXACT [] +synonym: "cinnamylic acid ester biosynthesis" EXACT [] +synonym: "cinnamylic acid ester biosynthetic process" EXACT [] +synonym: "phenylacrylic acid ester biosynthesis" EXACT [] +synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009801 ! cinnamic acid ester metabolic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +relationship: part_of GO:0009803 ! cinnamic acid metabolic process + +[Term] +id: GO:0009803 +name: cinnamic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] +synonym: "cinnamic acid metabolism" EXACT [] +synonym: "cinnamylic acid metabolic process" EXACT [] +synonym: "cinnamylic acid metabolism" EXACT [] +synonym: "phenylacrylic acid metabolic process" EXACT [] +synonym: "phenylacrylic acid metabolism" EXACT [] +synonym: "phenylpropenoic acid metabolic process" EXACT [] +synonym: "phenylpropenoic acid metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0009804 +name: coumarin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] +synonym: "coumarin metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0009805 +name: coumarin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] +synonym: "coumarin anabolism" EXACT [] +synonym: "coumarin biosynthesis" EXACT [] +synonym: "coumarin formation" EXACT [] +synonym: "coumarin synthesis" EXACT [] +xref: MetaCyc:PWY-5176 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process + +[Term] +id: GO:0009806 +name: lignan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +synonym: "lignan metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009807 +name: lignan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +synonym: "lignan anabolism" EXACT [] +synonym: "lignan biosynthesis" EXACT [] +synonym: "lignan formation" EXACT [] +synonym: "lignan synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009806 ! lignan metabolic process + +[Term] +id: GO:0009808 +name: lignin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] +synonym: "lignin metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:0009809 +name: lignin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] +synonym: "lignin anabolism" EXACT [] +synonym: "lignin biosynthesis" EXACT [] +synonym: "lignin formation" EXACT [] +synonym: "lignin synthesis" EXACT [] +xref: MetaCyc:PWY-361 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009808 ! lignin metabolic process + +[Term] +id: GO:0009810 +name: stilbene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:3110116251] +synonym: "stilbene metabolism" EXACT [] +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0009811 +name: stilbene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] +synonym: "stilbene anabolism" EXACT [] +synonym: "stilbene biosynthesis" EXACT [] +synonym: "stilbene formation" EXACT [] +synonym: "stilbene synthesis" EXACT [] +is_a: GO:0009810 ! stilbene metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0009812 +name: flavonoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] +synonym: "flavonoid metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0009813 +name: flavonoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] +synonym: "flavonoid anabolism" EXACT [] +synonym: "flavonoid biosynthesis" EXACT [] +synonym: "flavonoid formation" EXACT [] +synonym: "flavonoid synthesis" EXACT [] +xref: MetaCyc:PWY1F-FLAVSYN +xref: Wikipedia:Flavonoid +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0009815 +name: 1-aminocyclopropane-1-carboxylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene." [EC:1.14.17.4, RHEA:23640] +synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" RELATED [EC:1.14.17.4] +synonym: "ACC oxidase activity" EXACT [] +synonym: "aminocyclopropanecarboxylate oxidase activity" RELATED [EC:1.14.17.4] +synonym: "ethene-forming enzyme" BROAD [] +synonym: "ethylene-forming enzyme" BROAD [] +xref: EC:1.14.17.4 +xref: KEGG_REACTION:R07214 +xref: MetaCyc:ETHYL-RXN +xref: RHEA:23640 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0009819 +name: drought recovery +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] +synonym: "drought tolerance" RELATED [] +is_a: GO:0009414 ! response to water deprivation + +[Term] +id: GO:0009820 +name: alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] +subset: goslim_chembl +synonym: "alkaloid metabolism" EXACT [] +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0009821 +name: alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] +synonym: "alkaloid anabolism" EXACT [] +synonym: "alkaloid biosynthesis" EXACT [] +synonym: "alkaloid formation" EXACT [] +synonym: "alkaloid synthesis" EXACT [] +xref: UM-BBD_enzymeID:e0711 +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0009822 +name: alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] +synonym: "alkaloid breakdown" EXACT [] +synonym: "alkaloid catabolism" EXACT [] +synonym: "alkaloid degradation" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0009823 +name: cytokinin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] +synonym: "cytokinin breakdown" EXACT [] +synonym: "cytokinin catabolism" EXACT [] +synonym: "cytokinin degradation" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0009824 +name: AMP dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [EC:2.5.1.27, RHEA:15285] +synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] +synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R04038] +synonym: "adenylate dimethylallyltransferase activity" RELATED [EC:2.5.1.27] +synonym: "adenylate isopentenyltransferase activity" EXACT [] +synonym: "cytokinin synthase activity" RELATED [] +synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" RELATED [EC:2.5.1.27] +synonym: "isopentenyltransferase activity" BROAD [] +xref: EC:2.5.1.27 +xref: KEGG_REACTION:R04038 +xref: MetaCyc:RXN-4307 +xref: RHEA:15285 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0009825 +name: multidimensional cell growth +namespace: biological_process +def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] +synonym: "cell growth in three dimensions" EXACT [] +synonym: "cell growth in two dimensions" NARROW [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0009826 +name: unidimensional cell growth +namespace: biological_process +def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] +comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. +synonym: "cell elongation" NARROW [] +synonym: "cell growth along one axis" EXACT [] +synonym: "cell growth in one dimension" EXACT [] +synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] +synonym: "polar cell growth" EXACT [] +synonym: "polarized cell growth" EXACT [] +is_a: GO:0000902 ! cell morphogenesis +is_a: GO:0016049 ! cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis + +[Term] +id: GO:0009827 +name: plant-type cell wall modification +namespace: biological_process +def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing cell wall modification" EXACT [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0042545 ! cell wall modification + +[Term] +id: GO:0009828 +name: plant-type cell wall loosening +namespace: biological_process +def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] +is_a: GO:0009827 ! plant-type cell wall modification + +[Term] +id: GO:0009829 +name: cell wall modification involved in fruit ripening +namespace: biological_process +def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening." [GOC:lr] +synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb] +is_a: GO:0009827 ! plant-type cell wall modification +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0009835 ! fruit ripening + +[Term] +id: GO:0009830 +name: cell wall modification involved in abscission +namespace: biological_process +def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb] +synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb] +is_a: GO:0009827 ! plant-type cell wall modification +is_a: GO:0044277 ! cell wall disassembly +relationship: part_of GO:0009838 ! abscission + +[Term] +id: GO:0009831 +name: plant-type cell wall modification involved in multidimensional cell growth +namespace: biological_process +def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +synonym: "cell wall modification during cell expansion" BROAD [] +synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED [] +is_a: GO:0009827 ! plant-type cell wall modification +is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth + +[Term] +id: GO:0009832 +name: plant-type cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] +synonym: "cell wall anabolism" BROAD [] +synonym: "cell wall assembly" BROAD [] +synonym: "cell wall biosynthetic process" BROAD [] +synonym: "cell wall formation" BROAD [] +synonym: "cell wall synthesis" BROAD [] +synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] +is_a: GO:0042546 ! cell wall biogenesis +is_a: GO:0071669 ! plant-type cell wall organization or biogenesis + +[Term] +id: GO:0009833 +name: plant-type primary cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] +synonym: "primary cell wall anabolism" BROAD [] +synonym: "primary cell wall biogenesis" EXACT [] +synonym: "primary cell wall biosynthetic process" BROAD [] +synonym: "primary cell wall formation" BROAD [] +synonym: "primary cell wall synthesis" BROAD [] +is_a: GO:0009832 ! plant-type cell wall biogenesis +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:0009834 +name: plant-type secondary cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] +synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] +synonym: "secondary cell wall anabolism" BROAD [] +synonym: "secondary cell wall biogenesis" EXACT [] +synonym: "secondary cell wall biosynthetic process" BROAD [] +synonym: "secondary cell wall formation" BROAD [] +synonym: "secondary cell wall synthesis" BROAD [] +is_a: GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0009835 +name: fruit ripening +namespace: biological_process +def: "An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal." [GOC:lr] +subset: goslim_plant +synonym: "fruit maturation" RELATED [GOC:PO_curators] +synonym: "fruit senescence" RELATED [GOC:PO_curators] +xref: Wikipedia:Ripening +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0007568 ! aging +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:0009836 +name: fruit ripening, climacteric +namespace: biological_process +def: "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] +is_a: GO:0009835 ! fruit ripening + +[Term] +id: GO:0009837 +name: fruit ripening, non-climacteric +namespace: biological_process +def: "A fruit ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] +is_a: GO:0009835 ! fruit ripening + +[Term] +id: GO:0009838 +name: abscission +namespace: biological_process +def: "The controlled shedding of a body part." [ISBN:0140514031] +subset: goslim_plant +xref: Wikipedia:Abscission +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0009839 +name: obsolete SCF complex substrate recognition subunit +namespace: cellular_component +def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "SCF complex substrate recognition subunit" EXACT [] +is_obsolete: true +replaced_by: GO:0019005 + +[Term] +id: GO:0009840 +name: chloroplastic endopeptidase Clp complex +namespace: cellular_component +def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] +is_a: GO:0009368 ! endopeptidase Clp complex +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0009841 +name: mitochondrial endopeptidase Clp complex +namespace: cellular_component +def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] +is_a: GO:0009368 ! endopeptidase Clp complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0009842 +name: cyanelle +namespace: cellular_component +def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:0521316871, ISBN:1402001894] +synonym: "cyanoplast" EXACT [ISBN:1402001894] +synonym: "muroplast" EXACT [ISBN:1402001894] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0009843 +name: cyanelle thylakoid +namespace: cellular_component +def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] +is_a: GO:0031976 ! plastid thylakoid +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0009844 +name: obsolete germination +namespace: biological_process +alt_id: GO:0009565 +def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] +comment: This term was made obsolete because it is a grouping term without biological significance. +synonym: "germination" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009845 +name: seed germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] +xref: Wikipedia:Germination#Seed_germination +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0090351 ! seedling development + +[Term] +id: GO:0009846 +name: pollen germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] +is_a: GO:0022414 ! reproductive process +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0009847 +name: spore germination +namespace: biological_process +alt_id: GO:0075005 +def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] +synonym: "spore germination on or near host" NARROW [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0009848 +name: indoleacetic acid biosynthetic process via tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] +synonym: "IAA biosynthetic process via tryptophan" EXACT [] +synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] +synonym: "indoleacetic acid formation via tryptophan" EXACT [] +synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] +xref: MetaCyc:PWY-581 +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0009684 ! indoleacetic acid biosynthetic process + +[Term] +id: GO:0009849 +name: tryptophan-independent indoleacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] +synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] +synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] +synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] +synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] +synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] +synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] +synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] +xref: MetaCyc:PWY-581 +is_a: GO:0009684 ! indoleacetic acid biosynthetic process + +[Term] +id: GO:0009850 +name: auxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] +synonym: "auxin metabolism" EXACT [] +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0009851 +name: auxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] +synonym: "auxin anabolism" EXACT [] +synonym: "auxin biosynthesis" EXACT [] +synonym: "auxin formation" EXACT [] +synonym: "auxin synthesis" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0009852 +name: auxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] +synonym: "auxin breakdown" EXACT [] +synonym: "auxin catabolism" EXACT [] +synonym: "auxin degradation" EXACT [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0009853 +name: photorespiration +namespace: biological_process +def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732] +synonym: "photorespiratory pathway" EXACT [GOC:cjm] +xref: MetaCyc:PWY-181 +xref: Wikipedia:Photorespiration +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0009854 +name: oxidative photosynthetic carbon pathway +namespace: biological_process +def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:0943088399] +is_a: GO:0043094 ! cellular metabolic compound salvage +relationship: part_of GO:0009853 ! photorespiration + +[Term] +id: GO:0009855 +name: determination of bilateral symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] +synonym: "determination of bilateral asymmetry" EXACT [GOC:dph] +is_a: GO:0009799 ! specification of symmetry + +[Term] +id: GO:0009856 +name: pollination +namespace: biological_process +def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion." [GOC:tb, PMID:10973091] +subset: goslim_plant +xref: Wikipedia:Pollination +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0044706 ! multi-multicellular organism process + +[Term] +id: GO:0009858 +name: obsolete compatible pollen-pistil interaction +namespace: biological_process +def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +synonym: "compatible pollen-pistil interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009859 +name: pollen hydration +namespace: biological_process +def: "The process in which water is taken up by pollen." [GOC:lr] +is_a: GO:0006833 ! water transport +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0009860 +name: pollen tube growth +namespace: biological_process +def: "Growth of pollen via tip extension of the intine wall." [ISBN:0943088399] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009932 ! cell tip growth +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0009861 +name: jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] +synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] +is_a: GO:0009611 ! response to wounding +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0009862 +name: systemic acquired resistance, salicylic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] +synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] +synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] +is_a: GO:0009863 ! salicylic acid mediated signaling pathway +relationship: part_of GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0009863 +name: salicylic acid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] +synonym: "salicylic acid mediated signal transduction" EXACT [GOC:signaling] +synonym: "salicylic acid mediated signalling pathway" EXACT [] +synonym: "salicylic acid-mediated signaling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0071446 ! cellular response to salicylic acid stimulus + +[Term] +id: GO:0009864 +name: induced systemic resistance, jasmonic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] +synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0002252 ! immune effector process +is_a: GO:0009867 ! jasmonic acid mediated signaling pathway +relationship: part_of GO:0009682 ! induced systemic resistance + +[Term] +id: GO:0009865 +name: pollen tube adhesion +namespace: biological_process +def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0009875 ! pollen-pistil interaction +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0009866 +name: induced systemic resistance, ethylene mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] +synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] +synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] +synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] +synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] +is_a: GO:0002218 ! activation of innate immune response +is_a: GO:0002252 ! immune effector process +is_a: GO:0009873 ! ethylene-activated signaling pathway +relationship: part_of GO:0009682 ! induced systemic resistance + +[Term] +id: GO:0009867 +name: jasmonic acid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850] +synonym: "JA signaling" EXACT [PMID:20159850] +synonym: "jasmonate signaling" RELATED [PMID:16478936] +synonym: "jasmonic acid mediated signalling pathway" EXACT [] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071395 ! cellular response to jasmonic acid stimulus + +[Term] +id: GO:0009868 +name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] +synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] +is_a: GO:0009867 ! jasmonic acid mediated signaling pathway +relationship: part_of GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0009869 +name: obsolete incompatible pollen-pistil interaction +namespace: biological_process +def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] +comment: This term was made obsolete because it represents a phenotype. +synonym: "incompatible pollen-pistil interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009871 +name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] +synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] +synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] +synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] +synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] +is_a: GO:0009873 ! ethylene-activated signaling pathway +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0009872 +name: obsolete gametophytic self-incompatibility +namespace: biological_process +def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +synonym: "gametophytic self-incompatibility" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009873 +name: ethylene-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription." [GOC:jy, PMID:24012247] +synonym: "ethene mediated signaling pathway" RELATED [] +synonym: "ethene mediated signalling pathway" EXACT [] +synonym: "ethylene mediated signaling pathway" RELATED [] +synonym: "ethylene mediated signalling pathway" RELATED [] +synonym: "ethylene signal transduction" RELATED [PMID:24012247] +synonym: "ethylene signaling pathway" RELATED [PMID:24287137] +is_a: GO:0000160 ! phosphorelay signal transduction system +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071369 ! cellular response to ethylene stimulus + +[Term] +id: GO:0009874 +name: obsolete sporophytic self-incompatibility +namespace: biological_process +def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] +comment: This term was made obsolete because it represents a phenotype. +synonym: "sporophytic self-incompatibility" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009875 +name: pollen-pistil interaction +namespace: biological_process +def: "The interaction between a pollen grain and pistil." [PMID:27899537] +synonym: "pollen-gynoecium interaction" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0009876 +name: pollen adhesion +namespace: biological_process +def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] +is_a: GO:0022414 ! reproductive process +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0009877 +name: nodulation +namespace: biological_process +alt_id: GO:0009878 +def: "The formation of nitrogen-fixing root nodules on plant roots." [PMID:21856632, PMID:33317178] +synonym: "nodule development" EXACT [GOC:jl] +synonym: "nodule formation" EXACT [GOC:jl] +synonym: "nodule morphogenesis" RELATED [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0009879 +name: determination of radial symmetry +namespace: biological_process +def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] +synonym: "determination of radial asymmetry" EXACT [GOC:dph] +is_a: GO:0009799 ! specification of symmetry +relationship: part_of GO:0009956 ! radial pattern formation + +[Term] +id: GO:0009880 +name: embryonic pattern specification +namespace: biological_process +def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] +synonym: "embryonic pattern biosynthesis" BROAD [] +synonym: "embryonic pattern formation" BROAD [] +synonym: "ventral/lateral system" RELATED [] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0009881 +name: photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] +synonym: "blue-sensitive opsin" NARROW [] +synonym: "green-sensitive opsin" NARROW [] +synonym: "long-wave-sensitive opsin" NARROW [] +synonym: "opsin" NARROW [] +synonym: "red-sensitive opsin" NARROW [] +synonym: "short-wave-sensitive opsin" NARROW [] +synonym: "UV-sensitive opsin" NARROW [] +synonym: "violet-sensitive opsin" NARROW [] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0009882 +name: blue light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0009883 +name: red or far-red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] +synonym: "red/far-red light photoreceptor activity" EXACT [] +is_a: GO:0009881 ! photoreceptor activity + +[Term] +id: GO:0009884 +name: cytokinin receptor activity +namespace: molecular_function +def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:lr, GOC:signaling] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0009885 +name: transmembrane histidine kinase cytokinin receptor activity +namespace: molecular_function +def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] +is_a: GO:0009784 ! transmembrane receptor histidine kinase activity +is_a: GO:0009884 ! cytokinin receptor activity + +[Term] +id: GO:0009886 +name: post-embryonic animal morphogenesis +namespace: biological_process +def: "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators] +synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009791 ! post-embryonic development + +[Term] +id: GO:0009887 +name: animal organ morphogenesis +namespace: biological_process +def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] +synonym: "histogenesis and organogenesis" BROAD [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0009888 +name: tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] +synonym: "histogenesis" EXACT [] +synonym: "histogenesis and organogenesis" BROAD [] +xref: Wikipedia:Histogenesis +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0009889 +name: regulation of biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +synonym: "regulation of anabolism" EXACT [] +synonym: "regulation of biosynthesis" EXACT [] +synonym: "regulation of formation" EXACT [] +synonym: "regulation of synthesis" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009890 +name: negative regulation of biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +synonym: "down regulation of biosynthetic process" EXACT [] +synonym: "down-regulation of biosynthetic process" EXACT [] +synonym: "downregulation of biosynthetic process" EXACT [] +synonym: "inhibition of biosynthetic process" NARROW [] +synonym: "negative regulation of anabolism" EXACT [] +synonym: "negative regulation of biosynthesis" EXACT [] +synonym: "negative regulation of formation" EXACT [] +synonym: "negative regulation of synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0009892 ! negative regulation of metabolic process +relationship: negatively_regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009891 +name: positive regulation of biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] +synonym: "activation of biosynthetic process" NARROW [] +synonym: "positive regulation of anabolism" EXACT [] +synonym: "positive regulation of biosynthesis" EXACT [] +synonym: "positive regulation of formation" EXACT [] +synonym: "positive regulation of synthesis" EXACT [] +synonym: "stimulation of biosynthetic process" NARROW [] +synonym: "up regulation of biosynthetic process" EXACT [] +synonym: "up-regulation of biosynthetic process" EXACT [] +synonym: "upregulation of biosynthetic process" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0009893 ! positive regulation of metabolic process +relationship: positively_regulates GO:0009058 ! biosynthetic process + +[Term] +id: GO:0009892 +name: negative regulation of metabolic process +namespace: biological_process +alt_id: GO:0044252 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +synonym: "down regulation of metabolic process" EXACT [] +synonym: "down-regulation of metabolic process" EXACT [] +synonym: "downregulation of metabolic process" EXACT [] +synonym: "inhibition of metabolic process" NARROW [] +synonym: "inhibition of organismal metabolic process" NARROW [] +synonym: "negative regulation of metabolism" EXACT [] +synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] +synonym: "negative regulation of organismal metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0009893 +name: positive regulation of metabolic process +namespace: biological_process +alt_id: GO:0044253 +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +synonym: "activation of metabolic process" NARROW [] +synonym: "positive regulation of metabolism" EXACT [] +synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] +synonym: "positive regulation of organismal metabolism" NARROW [] +synonym: "stimulation of metabolic process" NARROW [] +synonym: "stimulation of organismal metabolic process" NARROW [] +synonym: "up regulation of metabolic process" EXACT [] +synonym: "up-regulation of metabolic process" EXACT [] +synonym: "up-regulation of organismal metabolic process" NARROW [] +synonym: "upregulation of metabolic process" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0009894 +name: regulation of catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +synonym: "regulation of breakdown" EXACT [] +synonym: "regulation of catabolism" EXACT [] +synonym: "regulation of degradation" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009895 +name: negative regulation of catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +synonym: "down regulation of catabolic process" EXACT [] +synonym: "down-regulation of catabolic process" EXACT [] +synonym: "downregulation of catabolic process" EXACT [] +synonym: "inhibition of catabolic process" NARROW [] +synonym: "negative regulation of breakdown" EXACT [] +synonym: "negative regulation of catabolism" EXACT [] +synonym: "negative regulation of degradation" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: negatively_regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009896 +name: positive regulation of catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] +synonym: "activation of catabolic process" NARROW [] +synonym: "positive regulation of breakdown" EXACT [] +synonym: "positive regulation of catabolism" EXACT [] +synonym: "positive regulation of degradation" EXACT [] +synonym: "stimulation of catabolic process" NARROW [] +synonym: "up regulation of catabolic process" EXACT [] +synonym: "up-regulation of catabolic process" EXACT [] +synonym: "upregulation of catabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: positively_regulates GO:0009056 ! catabolic process + +[Term] +id: GO:0009897 +name: external side of plasma membrane +namespace: cellular_component +def: "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] +synonym: "external leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "juxtamembrane" BROAD [] +synonym: "outer surface of cytoplasmic membrane" EXACT [] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0009898 +name: cytoplasmic side of plasma membrane +namespace: cellular_component +def: "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] +synonym: "internal leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "internal side of plasma membrane" EXACT [] +synonym: "juxtamembrane" BROAD [] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0009899 +name: ent-kaurene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22220] +synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.19] +synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" RELATED [EC:4.2.3.19] +synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] +synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] +xref: EC:4.2.3.19 +xref: KEGG_REACTION:R05092 +xref: MetaCyc:4.2.3.19-RXN +xref: RHEA:22220 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0009900 +name: dehiscence +namespace: biological_process +def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] +xref: Wikipedia:Dehiscence_(botany) +is_a: GO:0048609 ! multicellular organismal reproductive process + +[Term] +id: GO:0009901 +name: anther dehiscence +namespace: biological_process +def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] +is_a: GO:0009900 ! dehiscence +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0009902 +name: chloroplast relocation +namespace: biological_process +def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] +synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] +is_a: GO:0009658 ! chloroplast organization +is_a: GO:0019750 ! chloroplast localization +is_a: GO:0051667 ! establishment of plastid localization + +[Term] +id: GO:0009903 +name: chloroplast avoidance movement +namespace: biological_process +def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] +synonym: "high-fluence-rate response" RELATED [] +is_a: GO:0009902 ! chloroplast relocation + +[Term] +id: GO:0009904 +name: chloroplast accumulation movement +namespace: biological_process +def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] +synonym: "low-fluence-rate response" RELATED [] +is_a: GO:0009902 ! chloroplast relocation + +[Term] +id: GO:0009905 +name: ent-copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14841] +synonym: "diterpene cyclase activity" BROAD [] +synonym: "ent-copalyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.13] +synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] +synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] +xref: EC:5.5.1.13 +xref: KEGG_REACTION:R02068 +xref: MetaCyc:5.5.1.13-RXN +xref: RHEA:14841 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0009906 +name: response to photoperiod, blue light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0009907 +name: response to photoperiod, red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] +is_a: GO:0009648 ! photoperiodism +is_a: GO:0010114 ! response to red light + +[Term] +id: GO:0009908 +name: flower development +namespace: biological_process +alt_id: GO:0048409 +def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] +subset: goslim_plant +is_a: GO:0090567 ! reproductive shoot system development + +[Term] +id: GO:0009909 +name: regulation of flower development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0048831 ! regulation of shoot system development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009908 ! flower development + +[Term] +id: GO:0009910 +name: negative regulation of flower development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators] +synonym: "down regulation of flower development" EXACT [] +synonym: "down-regulation of flower development" EXACT [] +synonym: "downregulation of flower development" EXACT [] +synonym: "inhibition of flower development" NARROW [] +is_a: GO:0009909 ! regulation of flower development +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0009908 ! flower development + +[Term] +id: GO:0009911 +name: positive regulation of flower development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] +synonym: "activation of flower development" NARROW [] +synonym: "stimulation of flower development" NARROW [] +synonym: "up regulation of flower development" EXACT [] +synonym: "up-regulation of flower development" EXACT [] +synonym: "upregulation of flower development" EXACT [] +is_a: GO:0009909 ! regulation of flower development +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0009908 ! flower development + +[Term] +id: GO:0009912 +name: auditory receptor cell fate commitment +namespace: biological_process +def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] +synonym: "auditory hair cell fate commitment" EXACT [] +is_a: GO:0060120 ! inner ear receptor cell fate commitment +relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation + +[Term] +id: GO:0009913 +name: epidermal cell differentiation +namespace: biological_process +alt_id: GO:0043355 +def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] +synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0008544 ! epidermis development + +[Term] +id: GO:0009914 +name: hormone transport +namespace: biological_process +def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] +subset: goslim_pir +is_a: GO:0006810 ! transport +is_a: GO:0010817 ! regulation of hormone levels + +[Term] +id: GO:0009915 +name: phloem sucrose loading +namespace: biological_process +def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] +is_a: GO:0015770 ! sucrose transport +is_a: GO:0110126 ! phloem loading + +[Term] +id: GO:0009916 +name: alternative oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0009917 +name: sterol 5-alpha reductase activity +namespace: molecular_function +def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0009918 +name: sterol delta7 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] +synonym: "sterol delta-7 reductase activity" EXACT [] +xref: MetaCyc:RXN-707 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0009919 +name: obsolete cytokinesis (sensu Viridiplantae) +namespace: biological_process +def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] +comment: This term was made obsolete because its meaning was changed significantly. +synonym: "cytokinesis (sensu Viridiplantae)" EXACT [] +is_obsolete: true +consider: GO:0000911 + +[Term] +id: GO:0009920 +name: cell plate formation involved in plant-type cell wall biogenesis +namespace: biological_process +def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] +synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] +is_a: GO:0000919 ! cell plate assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0009921 +name: auxin efflux carrier complex +namespace: cellular_component +def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0009922 +name: fatty acid elongase activity +namespace: molecular_function +def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] +xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN +xref: Reactome:R-HSA-2046083 "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA" +xref: Reactome:R-HSA-2046088 "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA" +xref: Reactome:R-HSA-2046090 "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA" +xref: Reactome:R-HSA-2046094 "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA" +xref: Reactome:R-HSA-2046095 "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA" +xref: Reactome:R-HSA-2046100 "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA" +xref: Reactome:R-HSA-548800 "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA" +xref: Reactome:R-HSA-548814 "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA" +xref: Reactome:R-HSA-548815 "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA" +xref: Reactome:R-HSA-548830 "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA" +is_a: GO:0004312 ! fatty acid synthase activity + +[Term] +id: GO:0009923 +name: fatty acid elongase complex +namespace: cellular_component +def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0009924 +name: octadecanal decarbonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] +synonym: "octadecanal alkane-lyase activity" EXACT [] +xref: EC:4.1.99.5 +xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN +xref: RHEA:30415 +is_a: GO:0071771 ! aldehyde decarbonylase activity + +[Term] +id: GO:0009925 +name: basal plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0009926 +name: auxin polar transport +namespace: biological_process +def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] +is_a: GO:0060918 ! auxin transport + +[Term] +id: GO:0009927 +name: histidine phosphotransfer kinase activity +namespace: molecular_function +def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0009930 +name: longitudinal side of cell surface +namespace: cellular_component +def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0009931 +name: calcium-dependent protein serine/threonine kinase activity +namespace: molecular_function +def: "Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate." [GOC:mah] +comment: These reactions are dependent on the presence of calcium ions. +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0010857 ! calcium-dependent protein kinase activity + +[Term] +id: GO:0009932 +name: cell tip growth +namespace: biological_process +def: "Growth that occurs specifically at the tip of a cell." [GOC:jid] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0009933 +name: meristem structural organization +namespace: biological_process +def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] +synonym: "meristem organisation" BROAD [] +synonym: "meristem organization" BROAD [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0009934 +name: regulation of meristem structural organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid] +synonym: "regulation of meristem organisation" EXACT [] +synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0009933 ! meristem structural organization + +[Term] +id: GO:0009935 +name: obsolete nutrient import +namespace: biological_process +def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] +comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. +synonym: "nutrient import" EXACT [] +synonym: "nutrient uptake" EXACT [] +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0009936 +name: obsolete expansin +namespace: molecular_function +def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "expansin" EXACT [] +is_obsolete: true +consider: GO:0009505 +consider: GO:0016049 + +[Term] +id: GO:0009937 +name: regulation of gibberellic acid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] +synonym: "regulation of gibberellic acid mediated signalling" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway + +[Term] +id: GO:0009938 +name: negative regulation of gibberellic acid mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] +synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] +synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] +synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] +is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway + +[Term] +id: GO:0009939 +name: positive regulation of gibberellic acid mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] +synonym: "activation of gibberellic acid mediated signaling" NARROW [] +synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] +synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] +synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] +synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] +is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway + +[Term] +id: GO:0009940 +name: amino-terminal vacuolar sorting propeptide binding +namespace: molecular_function +def: "Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles." [GOC:sm, PMID:10871276] +is_a: GO:0010209 ! vacuolar sorting signal binding + +[Term] +id: GO:0009941 +name: chloroplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0009942 +name: longitudinal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] +synonym: "apical-basal pattern specification" EXACT [] +synonym: "longitudinal axis determination" RELATED [GOC:dph] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0009793 ! embryo development ending in seed dormancy + +[Term] +id: GO:0009943 +name: adaxial/abaxial axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] +synonym: "adaxial/abaxial determination" RELATED [GOC:dph] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009955 ! adaxial/abaxial pattern specification + +[Term] +id: GO:0009944 +name: polarity specification of adaxial/abaxial axis +namespace: biological_process +def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009943 ! adaxial/abaxial axis specification + +[Term] +id: GO:0009945 +name: radial axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009956 ! radial pattern formation + +[Term] +id: GO:0009946 +name: proximal/distal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "proximal/distal axis determination" RELATED [GOC:dph] +synonym: "proximodistal axis specification" EXACT [] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0009947 +name: centrolateral axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:dsz, GOC:tb, ISBN:0865427429] +synonym: "centrolateral axis determination" RELATED [GOC:dph] +synonym: "mediolateral axis specification" EXACT [] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0097353 ! centrolateral pattern formation + +[Term] +id: GO:0009948 +name: anterior/posterior axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "anterior/posterior axis determination" RELATED [GOC:dph] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009952 ! anterior/posterior pattern specification + +[Term] +id: GO:0009949 +name: polarity specification of anterior/posterior axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0009950 +name: dorsal/ventral axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] +synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] +synonym: "dorsoventral axis specification" EXACT [GOC:mah] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0009951 +name: polarity specification of dorsal/ventral axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] +synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah] +synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0009952 +name: anterior/posterior pattern specification +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] +synonym: "anterior/posterior pattern formation" RELATED [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009953 +name: dorsal/ventral pattern formation +namespace: biological_process +def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] +synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] +synonym: "dorsal/ventral pattern specification" NARROW [] +synonym: "dorsoventral pattern formation" EXACT [GOC:mah] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009954 +name: proximal/distal pattern formation +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "proximal/distal pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009955 +name: adaxial/abaxial pattern specification +namespace: biological_process +def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "adaxial/abaxial pattern formation" RELATED [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009956 +name: radial pattern formation +namespace: biological_process +def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] +synonym: "radial pattern specification" NARROW [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0009957 +name: epidermal cell fate specification +namespace: biological_process +alt_id: GO:0043356 +def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] +synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0009958 +name: positive gravitropism +namespace: biological_process +def: "The orientation of plant parts towards gravity." [GOC:sm] +synonym: "root gravitropism" NARROW [] +is_a: GO:0009630 ! gravitropism + +[Term] +id: GO:0009959 +name: negative gravitropism +namespace: biological_process +def: "The orientation of plant parts away from gravity." [GOC:sm] +synonym: "shoot gravitropism" NARROW [] +is_a: GO:0009630 ! gravitropism + +[Term] +id: GO:0009960 +name: endosperm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0009961 +name: response to 1-aminocyclopropane-1-carboxylic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:0009962 +name: regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +synonym: "regulation of flavonoid anabolism" EXACT [] +synonym: "regulation of flavonoid biosynthesis" EXACT [] +synonym: "regulation of flavonoid formation" EXACT [] +synonym: "regulation of flavonoid synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009963 +name: positive regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +synonym: "activation of flavonoid biosynthetic process" NARROW [] +synonym: "positive regulation of flavonoid anabolism" EXACT [] +synonym: "positive regulation of flavonoid biosynthesis" EXACT [] +synonym: "positive regulation of flavonoid formation" EXACT [] +synonym: "positive regulation of flavonoid synthesis" EXACT [] +synonym: "stimulation of flavonoid biosynthetic process" NARROW [] +synonym: "up regulation of flavonoid biosynthetic process" EXACT [] +synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] +synonym: "upregulation of flavonoid biosynthetic process" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009964 +name: negative regulation of flavonoid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] +synonym: "down regulation of flavonoid biosynthetic process" EXACT [] +synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] +synonym: "downregulation of flavonoid biosynthetic process" EXACT [] +synonym: "inhibition of flavonoid biosynthetic process" NARROW [] +synonym: "negative regulation of flavonoid anabolism" EXACT [] +synonym: "negative regulation of flavonoid biosynthesis" EXACT [] +synonym: "negative regulation of flavonoid formation" EXACT [] +synonym: "negative regulation of flavonoid synthesis" EXACT [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process + +[Term] +id: GO:0009965 +name: leaf morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators] +is_a: GO:1905392 ! plant organ morphogenesis +relationship: part_of GO:0010016 ! shoot system morphogenesis +relationship: part_of GO:0048366 ! leaf development + +[Term] +id: GO:0009966 +name: regulation of signal transduction +namespace: biological_process +alt_id: GO:0035466 +def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] +synonym: "regulation of signaling pathway" RELATED [] +synonym: "regulation of signalling pathway" RELATED [GOC:mah] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009967 +name: positive regulation of signal transduction +namespace: biological_process +alt_id: GO:0035468 +def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] +synonym: "activation of signal transduction" NARROW [] +synonym: "positive regulation of signaling pathway" RELATED [] +synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] +synonym: "stimulation of signal transduction" NARROW [] +synonym: "up regulation of signal transduction" EXACT [] +synonym: "up-regulation of signal transduction" EXACT [] +synonym: "upregulation of signal transduction" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009968 +name: negative regulation of signal transduction +namespace: biological_process +alt_id: GO:0035467 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] +synonym: "down regulation of signal transduction" EXACT [] +synonym: "down-regulation of signal transduction" EXACT [] +synonym: "downregulation of signal transduction" EXACT [] +synonym: "inhibition of signal transduction" NARROW [] +synonym: "negative regulation of signaling pathway" RELATED [] +synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0007165 ! signal transduction + +[Term] +id: GO:0009969 +name: xyloglucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:sm] +synonym: "xyloglucan anabolism" EXACT [] +synonym: "xyloglucan biosynthesis" EXACT [] +synonym: "xyloglucan formation" EXACT [] +synonym: "xyloglucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0010411 ! xyloglucan metabolic process +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0009970 +name: cellular response to sulfate starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] +synonym: "cellular response to sulphate starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0009971 +name: anastral spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +is_a: GO:0055048 ! anastral spindle assembly + +[Term] +id: GO:0009972 +name: cytidine deamination +namespace: biological_process +def: "The removal of amino group in the presence of water." [GOC:sm] +is_a: GO:0006216 ! cytidine catabolic process + +[Term] +id: GO:0009973 +name: adenylyl-sulfate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] +synonym: "adenosine 5'-phosphosulfate reductase" RELATED [EC:1.8.99.2] +synonym: "adenosine phosphosulfate reductase activity" RELATED [EC:1.8.99.2] +synonym: "adenylyl-sulphate reductase activity" RELATED [EC:1.8.99.2] +synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.99.2] +synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.99.2] +synonym: "APS reductase activity" RELATED [EC:1.8.99.2] +synonym: "APS-reductase" RELATED [EC:1.8.99.2] +xref: EC:1.8.99.2 +xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN +xref: RHEA:24240 +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0009974 +name: zeinoxanthin epsilon hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [PMID:8837513, RHEA:57352] +xref: EC:1.14.14.158 +xref: MetaCyc:RXN-5962 +xref: RHEA:57352 +is_a: GO:0072374 ! carotene epsilon hydroxylase activity + +[Term] +id: GO:0009975 +name: cyclase activity +namespace: molecular_function +def: "Catalysis of a ring closure reaction." [ISBN:0198547684] +subset: goslim_generic +subset: goslim_pir +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0009976 +name: tocopherol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0009977 +name: proton motive force dependent protein transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015557 +def: "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245, PMID:25494301] +synonym: "arginine targeting transmembrane transporter activity" EXACT [] +synonym: "delta-pH-dependent protein transporter activity" EXACT [] +synonym: "pH-dependent protein transporter activity" EXACT [] +synonym: "twin-arginine targeting transmembrane transporter activity" EXACT [] +is_a: GO:0008320 ! protein transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0009978 +name: allene oxide synthase activity +namespace: molecular_function +alt_id: GO:0047987 +def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] +synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] +synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity" RELATED [EC:4.2.1.92] +synonym: "HPI" RELATED [EC:4.2.1.92] +synonym: "hydroperoxide dehydratase activity" RELATED [] +synonym: "hydroperoxide isomerase activity" RELATED [EC:4.2.1.92] +synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] +synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] +xref: EC:4.2.1.92 +xref: MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN +xref: MetaCyc:RXN1F-19 +xref: RHEA:25074 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0009979 +name: 16:0 monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307] +is_a: GO:0042389 ! omega-3 fatty acid desaturase activity + +[Term] +id: GO:0009980 +name: obsolete glutamate carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] +synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] +synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] +synonym: "glutamate carboxypeptidase activity" EXACT [] +synonym: "glutamyl carboxypeptidase activity" RELATED [EC:3.4.17.11] +synonym: "N-pteroyl-L-glutamate hydrolase activity" RELATED [EC:3.4.17.11] +is_obsolete: true +replaced_by: GO:0004180 + +[Term] +id: GO:0009982 +name: pseudouridine synthase activity +namespace: molecular_function +alt_id: GO:0016439 +def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah] +comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. +xref: Reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs" +xref: Reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs" +xref: Reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)" +xref: Reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA" +xref: Reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA" +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0009983 +name: obsolete tyrosine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +synonym: "tyrosine aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0009984 +name: obsolete adenylate forming enzyme activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] +comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. +synonym: "adenylate forming enzyme activity" EXACT [] +is_obsolete: true +consider: GO:0046033 + +[Term] +id: GO:0009985 +name: obsolete dihydroflavonol(thiole) lyase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:tb] +comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. +synonym: "dihydroflavonol(thiole) lyase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0009986 +name: cell surface +namespace: cellular_component +alt_id: GO:0009928 +alt_id: GO:0009929 +def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] +comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. +subset: goslim_pir +synonym: "cell associated" EXACT [] +synonym: "cell bound" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0009987 +name: cellular process +namespace: biological_process +alt_id: GO:0008151 +alt_id: GO:0044763 +alt_id: GO:0050875 +def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] +subset: gocheck_do_not_annotate +subset: goslim_plant +synonym: "cell growth and/or maintenance" NARROW [] +synonym: "cell physiology" EXACT [] +synonym: "cellular physiological process" EXACT [] +synonym: "single-organism cellular process" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0009988 +name: cell-cell recognition +namespace: biological_process +def: "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] +is_a: GO:0008037 ! cell recognition + +[Term] +id: GO:0009989 +name: cell-matrix recognition +namespace: biological_process +def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] +is_a: GO:0008037 ! cell recognition + +[Term] +id: GO:0009990 +name: contact guidance +namespace: biological_process +def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] +is_a: GO:0009989 ! cell-matrix recognition + +[Term] +id: GO:0009991 +name: response to extracellular stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0009992 +name: cellular water homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of water within a cell." [GOC:dph, GOC:tb] +synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006884 ! cell volume homeostasis +is_a: GO:0030104 ! water homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0009994 +name: oocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] +synonym: "oocyte cell differentiation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0009995 +name: soluble molecule recognition +namespace: biological_process +def: "The recognition of soluble molecules in the environment." [GOC:go_curators] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0009996 +name: negative regulation of cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] +synonym: "down regulation of cell fate specification" EXACT [] +synonym: "down-regulation of cell fate specification" EXACT [] +synonym: "downregulation of cell fate specification" EXACT [] +synonym: "inhibition of cell fate specification" NARROW [] +synonym: "suppression of cell fate" EXACT [] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0042659 ! regulation of cell fate specification +relationship: negatively_regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0009997 +name: negative regulation of cardioblast cell fate specification +namespace: biological_process +alt_id: GO:0042687 +def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +synonym: "down regulation of cardioblast cell fate specification" EXACT [] +synonym: "down-regulation of cardioblast cell fate specification" EXACT [] +synonym: "downregulation of cardioblast cell fate specification" EXACT [] +synonym: "inhibition of cardioblast cell fate specification" NARROW [] +synonym: "suppression of cardioblast cell fate" EXACT [] +is_a: GO:0042686 ! regulation of cardioblast cell fate specification +is_a: GO:0051892 ! negative regulation of cardioblast differentiation +is_a: GO:2000044 ! negative regulation of cardiac cell fate specification +relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification + +[Term] +id: GO:0009998 +name: negative regulation of retinal cone cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] +synonym: "down regulation of retinal cone cell fate specification" EXACT [] +synonym: "down-regulation of retinal cone cell fate specification" EXACT [] +synonym: "downregulation of retinal cone cell fate specification" EXACT [] +synonym: "inhibition of retinal cone cell fate specification" NARROW [] +synonym: "negative regulation of retina cone cell fate specification" EXACT [] +synonym: "suppression of retina cone cell fate" EXACT [] +synonym: "suppression of retinal cone cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042673 ! regulation of retinal cone cell fate specification +is_a: GO:0060226 ! negative regulation of retinal cone cell fate commitment +relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification + +[Term] +id: GO:0009999 +name: negative regulation of auditory receptor cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] +synonym: "down regulation of auditory receptor cell fate specification" EXACT [] +synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] +synonym: "downregulation of auditory receptor cell fate specification" EXACT [] +synonym: "inhibition of auditory receptor cell fate specification" NARROW [] +synonym: "negative regulation of auditory hair cell fate specification" EXACT [] +synonym: "suppression of auditory receptor cell fate" EXACT [] +synonym: "suppression of hair cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042669 ! regulation of inner ear auditory receptor cell fate specification +is_a: GO:0045608 ! negative regulation of inner ear auditory receptor cell differentiation +relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification + +[Term] +id: GO:0010001 +name: glial cell differentiation +namespace: biological_process +alt_id: GO:0007404 +alt_id: GO:0043360 +def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] +synonym: "glia cell differentiation" EXACT [] +synonym: "neuroglia differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0010002 +name: cardioblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] +synonym: "cardioblast cell differentiation" EXACT [] +synonym: "cardiomyocyte generation" RELATED [] +is_a: GO:0035051 ! cardiocyte differentiation +is_a: GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0010004 +name: gastrulation involving germ band extension +namespace: biological_process +def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0001703 ! gastrulation with mouth forming first + +[Term] +id: GO:0010005 +name: cortical microtubule, transverse to long axis +namespace: cellular_component +def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] +is_a: GO:0055028 ! cortical microtubule + +[Term] +id: GO:0010006 +name: Toc complex +namespace: cellular_component +def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0010007 +name: magnesium chelatase complex +namespace: cellular_component +def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0010008 +name: endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an endosome." [GOC:mah] +synonym: "endosomal membrane" EXACT [NIF_Subcellular:sao978443756] +xref: NIF_Subcellular:sao978443756 +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0010009 +name: cytoplasmic side of endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the endosome membrane that faces the cytoplasm." [GOC:lr] +synonym: "external leaflet of endosome membrane" EXACT [GOC:ab] +synonym: "external side of endosome membrane" EXACT [] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0010011 +name: auxin binding +namespace: molecular_function +def: "Binding to auxin, a plant hormone that regulates aspects of plant growth." [GOC:sm] +synonym: "auxin receptor" NARROW [] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0010012 +name: steroid 22-alpha hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0010013 +name: N-1-naphthylphthalamic acid binding +namespace: molecular_function +def: "Binding to N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] +is_a: GO:0033218 ! amide binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0010014 +name: meristem initiation +namespace: biological_process +def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009933 ! meristem structural organization + +[Term] +id: GO:0010015 +name: root morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] +is_a: GO:1905392 ! plant organ morphogenesis +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010016 +name: shoot system morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] +synonym: "shoot morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048367 ! shoot system development + +[Term] +id: GO:0010017 +name: red or far-red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] +synonym: "phytochrome signaling pathway" BROAD [] +synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb] +synonym: "red or far-red light signal transduction" EXACT [GOC:signaling] +synonym: "red or far-red light signalling pathway" EXACT [] +synonym: "red/far red light signaling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction +is_a: GO:0071489 ! cellular response to red or far red light + +[Term] +id: GO:0010018 +name: far-red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] +synonym: "far red light signalling pathway" EXACT [] +synonym: "far red signaling pathway" EXACT [GOC:tb] +synonym: "far-red light signal transduction" EXACT [GOC:signaling] +is_a: GO:0010017 ! red or far-red light signaling pathway +is_a: GO:0071490 ! cellular response to far red light + +[Term] +id: GO:0010019 +name: chloroplast-nucleus signaling pathway +namespace: biological_process +def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] +synonym: "chloroplast-nucleus signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0010020 +name: chloroplast fission +namespace: biological_process +def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] +synonym: "chloroplast division" EXACT [] +is_a: GO:0009658 ! chloroplast organization +is_a: GO:0043572 ! plastid fission + +[Term] +id: GO:0010021 +name: amylopectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages." [ISBN:0943088399] +synonym: "amylopectin anabolism" EXACT [] +synonym: "amylopectin biosynthesis" EXACT [] +synonym: "amylopectin formation" EXACT [] +synonym: "amylopectin synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:2000896 ! amylopectin metabolic process + +[Term] +id: GO:0010022 +name: meristem determinacy +namespace: biological_process +def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0010073 ! meristem maintenance + +[Term] +id: GO:0010023 +name: proanthocyanidin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] +synonym: "proanthocyanidin anabolism" EXACT [] +synonym: "proanthocyanidin biosynthesis" EXACT [] +synonym: "proanthocyanidin formation" EXACT [] +synonym: "proanthocyanidin synthesis" EXACT [] +xref: MetaCyc:PWY-641 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0010024 +name: phytochromobilin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] +synonym: "phytochromobilin anabolism" EXACT [] +synonym: "phytochromobilin biosynthesis" EXACT [] +synonym: "phytochromobilin formation" EXACT [] +synonym: "phytochromobilin synthesis" EXACT [] +is_a: GO:0033014 ! tetrapyrrole biosynthetic process +is_a: GO:0051202 ! phytochromobilin metabolic process + +[Term] +id: GO:0010025 +name: wax biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] +synonym: "wax anabolism" EXACT [] +synonym: "wax biosynthesis" EXACT [] +synonym: "wax formation" EXACT [] +synonym: "wax synthesis" EXACT [] +xref: MetaCyc:PWY-282 +is_a: GO:0010166 ! wax metabolic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process + +[Term] +id: GO:0010026 +name: trichome differentiation +namespace: biological_process +alt_id: GO:0048271 +def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433] +synonym: "trichome cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0090558 ! plant epidermis development + +[Term] +id: GO:0010027 +name: thylakoid membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] +comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. +synonym: "thylakoid membrane organisation" EXACT [] +synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009668 ! plastid membrane organization + +[Term] +id: GO:0010028 +name: xanthophyll cycle +namespace: biological_process +def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] +xref: MetaCyc:PWY-1141 +xref: Wikipedia:Xanthophyll#Xanthophyll_cycle +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0010029 +name: regulation of seed germination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] +is_a: GO:1900140 ! regulation of seedling development +relationship: regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010030 +name: positive regulation of seed germination +namespace: biological_process +def: "Any process that activates or increase the rate of seed germination." [GOC:sm] +synonym: "activation of seed germination" NARROW [] +synonym: "stimulation of seed germination" NARROW [] +synonym: "up regulation of seed germination" EXACT [] +synonym: "up-regulation of seed germination" EXACT [] +synonym: "upregulation of seed germination" EXACT [] +is_a: GO:0010029 ! regulation of seed germination +is_a: GO:0048582 ! positive regulation of post-embryonic development +relationship: positively_regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010031 +name: circumnutation +namespace: biological_process +def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] +is_a: GO:0050879 ! multicellular organismal movement + +[Term] +id: GO:0010032 +name: meiotic chromosome condensation +namespace: biological_process +def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] +synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0030261 ! chromosome condensation +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle + +[Term] +id: GO:0010033 +name: response to organic substance +namespace: biological_process +alt_id: GO:1990367 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm, PMID:23356676] +synonym: "process resulting in tolerance to organic substance" NARROW [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0010034 +name: response to acetate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010035 +name: response to inorganic substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0010036 +name: response to boron-containing substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm] +synonym: "response to boron" EXACT [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0010037 +name: response to carbon dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010038 +name: response to metal ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] +synonym: "heavy metal sensitivity/resistance" RELATED [] +synonym: "response to heavy metal" NARROW [] +synonym: "response to metal" EXACT [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010039 +name: response to iron ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] +synonym: "response to iron" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010040 +name: response to iron(II) ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] +synonym: "response to iron(II)" EXACT [] +is_a: GO:0010039 ! response to iron ion + +[Term] +id: GO:0010041 +name: response to iron(III) ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] +synonym: "response to iron(III)" EXACT [] +is_a: GO:0010039 ! response to iron ion + +[Term] +id: GO:0010042 +name: response to manganese ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] +synonym: "response to manganese" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010043 +name: response to zinc ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] +synonym: "response to zinc" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010044 +name: response to aluminum ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] +synonym: "response to aluminium ion" EXACT [] +synonym: "response to aluminum" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010045 +name: response to nickel cation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus." [GOC:sm] +synonym: "response to nickel" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010046 +name: response to mycotoxin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:sm] +is_a: GO:0009636 ! response to toxic substance + +[Term] +id: GO:0010047 +name: fruit dehiscence +namespace: biological_process +def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] +is_a: GO:0009900 ! dehiscence + +[Term] +id: GO:0010048 +name: vernalization response +namespace: biological_process +def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0010049 +name: acquisition of plant reproductive competence +namespace: biological_process +def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] +synonym: "acquisition of reproductive competence" BROAD [] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0010050 +name: vegetative phase change +namespace: biological_process +def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0010051 +name: xylem and phloem pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] +synonym: "vascular tissue pattern formation" EXACT [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0010052 +name: guard cell differentiation +namespace: biological_process +def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] +synonym: "stomatal cell differentiation" RELATED [] +is_a: GO:0090627 ! plant epidermal cell differentiation +relationship: part_of GO:0010103 ! stomatal complex morphogenesis + +[Term] +id: GO:0010053 +name: root epidermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] +is_a: GO:0090627 ! plant epidermal cell differentiation +relationship: part_of GO:0010015 ! root morphogenesis +relationship: part_of GO:0090558 ! plant epidermis development + +[Term] +id: GO:0010054 +name: trichoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] +synonym: "trichoblast cell differentiation" EXACT [] +is_a: GO:0010053 ! root epidermal cell differentiation + +[Term] +id: GO:0010055 +name: atrichoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] +is_a: GO:0010053 ! root epidermal cell differentiation + +[Term] +id: GO:0010056 +name: atrichoblast fate specification +namespace: biological_process +def: "The process involved in the specification of an atrichoblast." [GOC:tb] +is_a: GO:0090628 ! plant epidermal cell fate specification +relationship: part_of GO:0010055 ! atrichoblast differentiation + +[Term] +id: GO:0010057 +name: trichoblast fate specification +namespace: biological_process +def: "The process involved in the specification of a trichoblast." [GOC:tb] +is_a: GO:0090628 ! plant epidermal cell fate specification +relationship: part_of GO:0010054 ! trichoblast differentiation + +[Term] +id: GO:0010058 +name: regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that modulates atrichoblast fate specification." [GOC:tb] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:1903888 ! regulation of plant epidermal cell differentiation +relationship: regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010059 +name: positive regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] +synonym: "activation of atrichoblast fate" NARROW [] +synonym: "stimulation of atrichoblast fate" NARROW [] +synonym: "up regulation of atrichoblast fate" EXACT [] +synonym: "up-regulation of atrichoblast fate" EXACT [] +synonym: "upregulation of atrichoblast fate" EXACT [] +is_a: GO:0010058 ! regulation of atrichoblast fate specification +is_a: GO:0042660 ! positive regulation of cell fate specification +is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation +relationship: positively_regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010060 +name: negative regulation of atrichoblast fate specification +namespace: biological_process +def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] +synonym: "down regulation of atrichoblast fate" EXACT [] +synonym: "down-regulation of atrichoblast fate" EXACT [] +synonym: "downregulation of atrichoblast fate" EXACT [] +synonym: "inhibition of atrichoblast fate" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0010058 ! regulation of atrichoblast fate specification +is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation +relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification + +[Term] +id: GO:0010061 +name: regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that modulates trichoblast fate specification." [GOC:tb] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:1903888 ! regulation of plant epidermal cell differentiation +is_a: GO:2000067 ! regulation of root morphogenesis +relationship: regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010062 +name: negative regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that suppresses trichoblast fate specification." [GOC:tb] +synonym: "down regulation of trichoblast fate" EXACT [] +synonym: "down-regulation of trichoblast fate" EXACT [] +synonym: "downregulation of trichoblast fate" EXACT [] +synonym: "inhibition of trichoblast fate" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0010061 ! regulation of trichoblast fate specification +is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation +relationship: negatively_regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010063 +name: positive regulation of trichoblast fate specification +namespace: biological_process +def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] +synonym: "activation of trichoblast fate" NARROW [] +synonym: "stimulation of trichoblast fate" NARROW [] +synonym: "up regulation of trichoblast fate" EXACT [] +synonym: "up-regulation of trichoblast fate" EXACT [] +synonym: "upregulation of trichoblast fate" EXACT [] +is_a: GO:0010061 ! regulation of trichoblast fate specification +is_a: GO:0042660 ! positive regulation of cell fate specification +is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation +relationship: positively_regulates GO:0010057 ! trichoblast fate specification + +[Term] +id: GO:0010064 +name: embryonic shoot morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb] +synonym: "primary shoot system morphogenesis" EXACT [] +is_a: GO:0010016 ! shoot system morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010065 +name: primary meristem tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] +synonym: "primary meristem histogenesis" EXACT [] +is_a: GO:0048508 ! embryonic meristem development + +[Term] +id: GO:0010066 +name: ground meristem histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010067 +name: procambium histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010068 +name: protoderm histogenesis +namespace: biological_process +def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] +is_a: GO:0010065 ! primary meristem tissue development + +[Term] +id: GO:0010069 +name: zygote asymmetric cytokinesis in embryo sac +namespace: biological_process +def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] +is_a: GO:0000281 ! mitotic cytokinesis +is_a: GO:0010070 ! zygote asymmetric cell division +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0009793 ! embryo development ending in seed dormancy + +[Term] +id: GO:0010070 +name: zygote asymmetric cell division +namespace: biological_process +def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] +synonym: "zygote asymmetric cytokinesis" RELATED [] +is_a: GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0010071 +name: root meristem specification +namespace: biological_process +def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090421 ! embryonic meristem initiation +relationship: part_of GO:0010015 ! root morphogenesis +relationship: part_of GO:0048508 ! embryonic meristem development + +[Term] +id: GO:0010072 +name: primary shoot apical meristem specification +namespace: biological_process +def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb] +synonym: "embryo shoot apical meristem specification" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090421 ! embryonic meristem initiation +relationship: part_of GO:0010016 ! shoot system morphogenesis +relationship: part_of GO:0048508 ! embryonic meristem development + +[Term] +id: GO:0010073 +name: meristem maintenance +namespace: biological_process +def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0010074 +name: maintenance of meristem identity +namespace: biological_process +alt_id: GO:0032503 +def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] +synonym: "maintenance of meristem cell identity" EXACT [] +synonym: "meristem cell maintenance" EXACT [] +is_a: GO:0019827 ! stem cell population maintenance +relationship: part_of GO:0010073 ! meristem maintenance + +[Term] +id: GO:0010075 +name: regulation of meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] +synonym: "regulation of meristem size" EXACT [GOC:tb] +is_a: GO:0048638 ! regulation of developmental growth +relationship: part_of GO:0010073 ! meristem maintenance +relationship: regulates GO:0035266 ! meristem growth + +[Term] +id: GO:0010076 +name: maintenance of floral meristem identity +namespace: biological_process +def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010077 +name: maintenance of inflorescence meristem identity +namespace: biological_process +def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010078 +name: maintenance of root meristem identity +namespace: biological_process +def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity +relationship: part_of GO:0010015 ! root morphogenesis + +[Term] +id: GO:0010079 +name: maintenance of vegetative meristem identity +namespace: biological_process +def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010080 +name: regulation of floral meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] +synonym: "regulation of floral meristem size" EXACT [] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0010451 ! floral meristem growth + +[Term] +id: GO:0010081 +name: regulation of inflorescence meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] +synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0010450 ! inflorescence meristem growth + +[Term] +id: GO:0010082 +name: regulation of root meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] +synonym: "regulation of root meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +relationship: part_of GO:0010015 ! root morphogenesis +relationship: regulates GO:0010449 ! root meristem growth + +[Term] +id: GO:0010083 +name: regulation of vegetative meristem growth +namespace: biological_process +def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] +synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] +is_a: GO:0010075 ! regulation of meristem growth +is_a: GO:1905613 ! regulation of developmental vegetative growth +relationship: regulates GO:0010448 ! vegetative meristem growth + +[Term] +id: GO:0010084 +name: specification of animal organ axis polarity +namespace: biological_process +def: "The process in which the polarity of an animal organ axis is specified." [GOC:tb] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0010085 +name: polarity specification of proximal/distal axis +namespace: biological_process +def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:0009946 ! proximal/distal axis specification + +[Term] +id: GO:0010086 +name: embryonic root morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb] +is_a: GO:0010015 ! root morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010087 +name: phloem or xylem histogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] +synonym: "vascular tissue development" BROAD [] +synonym: "vascular tissue histogenesis" EXACT [] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0010088 +name: phloem development +namespace: biological_process +def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] +synonym: "phloem histogenesis" EXACT [GOC:tb] +is_a: GO:0010087 ! phloem or xylem histogenesis + +[Term] +id: GO:0010089 +name: xylem development +namespace: biological_process +def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] +synonym: "xylem histogenesis" EXACT [GOC:tb] +is_a: GO:0010087 ! phloem or xylem histogenesis + +[Term] +id: GO:0010090 +name: trichome morphogenesis +namespace: biological_process +alt_id: GO:0048272 +def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] +synonym: "trichome cell morphogenesis during differentiation" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0010026 ! trichome differentiation +relationship: part_of GO:0090626 ! plant epidermis morphogenesis + +[Term] +id: GO:0010091 +name: trichome branching +namespace: biological_process +alt_id: GO:0048274 +def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0010090 ! trichome morphogenesis + +[Term] +id: GO:0010092 +name: specification of animal organ identity +namespace: biological_process +def: "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0048645 ! animal organ formation + +[Term] +id: GO:0010093 +name: specification of floral organ identity +namespace: biological_process +def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090701 ! specification of plant organ identity +relationship: part_of GO:0048449 ! floral organ formation + +[Term] +id: GO:0010094 +name: specification of carpel identity +namespace: biological_process +def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048462 ! carpel formation + +[Term] +id: GO:0010095 +name: specification of petal identity +namespace: biological_process +def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048451 ! petal formation + +[Term] +id: GO:0010096 +name: specification of sepal identity +namespace: biological_process +def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048453 ! sepal formation + +[Term] +id: GO:0010097 +name: specification of stamen identity +namespace: biological_process +def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] +is_a: GO:0010093 ! specification of floral organ identity +relationship: part_of GO:0048455 ! stamen formation + +[Term] +id: GO:0010098 +name: suspensor development +namespace: biological_process +def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0010099 +name: regulation of photomorphogenesis +namespace: biological_process +def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:2000030 ! regulation of response to red or far red light +relationship: regulates GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0010100 +name: negative regulation of photomorphogenesis +namespace: biological_process +def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] +synonym: "down regulation of photomorphogenesis" EXACT [] +synonym: "down-regulation of photomorphogenesis" EXACT [] +synonym: "downregulation of photomorphogenesis" EXACT [] +synonym: "inhibition of photomorphogenesis" NARROW [] +is_a: GO:0010099 ! regulation of photomorphogenesis +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009640 ! photomorphogenesis + +[Term] +id: GO:0010101 +name: post-embryonic root morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] +is_a: GO:0010015 ! root morphogenesis +is_a: GO:0090697 ! post-embryonic plant organ morphogenesis +relationship: part_of GO:0048528 ! post-embryonic root development + +[Term] +id: GO:0010102 +name: lateral root morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] +is_a: GO:0010101 ! post-embryonic root morphogenesis +relationship: part_of GO:0048527 ! lateral root development + +[Term] +id: GO:0010103 +name: stomatal complex morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] +is_a: GO:0090626 ! plant epidermis morphogenesis +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0010016 ! shoot system morphogenesis +relationship: part_of GO:0010374 ! stomatal complex development + +[Term] +id: GO:0010104 +name: regulation of ethylene-activated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction." [GOC:tb] +synonym: "regulation of ethene mediated signaling pathway" EXACT [] +synonym: "regulation of ethene mediated signalling pathway" EXACT [] +synonym: "regulation of ethylene mediated signaling pathway" RELATED [] +synonym: "regulation of ethylene mediated signalling pathway" EXACT [] +is_a: GO:0070297 ! regulation of phosphorelay signal transduction system +relationship: regulates GO:0009873 ! ethylene-activated signaling pathway + +[Term] +id: GO:0010105 +name: negative regulation of ethylene-activated signaling pathway +namespace: biological_process +def: "Any process that stops or prevents ethylene (ethene) signal transduction." [GOC:tb] +synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] +synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] +synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] +synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] +synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] +synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] +synonym: "negative regulation of ethylene mediated signaling pathway" RELATED [] +synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] +is_a: GO:0010104 ! regulation of ethylene-activated signaling pathway +is_a: GO:0070298 ! negative regulation of phosphorelay signal transduction system +relationship: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway + +[Term] +id: GO:0010106 +name: cellular response to iron ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] +is_a: GO:0009267 ! cellular response to starvation +relationship: part_of GO:0006879 ! cellular iron ion homeostasis + +[Term] +id: GO:0010108 +name: detection of glutamine +namespace: biological_process +def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "glutamine detection" EXACT [] +synonym: "glutamine perception" RELATED [] +synonym: "glutamine sensing" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0010109 +name: regulation of photosynthesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0015979 ! photosynthesis + +[Term] +id: GO:0010110 +name: regulation of photosynthesis, dark reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0019685 ! photosynthesis, dark reaction + +[Term] +id: GO:0010111 +name: glyoxysome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] +synonym: "glyoxysome organisation" EXACT [] +synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007031 ! peroxisome organization +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0010112 +name: regulation of systemic acquired resistance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0010113 +name: negative regulation of systemic acquired resistance +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] +synonym: "down regulation of systemic acquired resistance" EXACT [] +synonym: "down-regulation of systemic acquired resistance" EXACT [] +synonym: "downregulation of systemic acquired resistance" EXACT [] +synonym: "inhibition of systemic acquired resistance" NARROW [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0010112 ! regulation of systemic acquired resistance +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +relationship: negatively_regulates GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:0010114 +name: response to red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] +synonym: "response to red light stimulus" EXACT [] +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0010115 +name: regulation of abscisic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] +synonym: "regulation of abscisic acid anabolism" EXACT [] +synonym: "regulation of abscisic acid biosynthesis" EXACT [] +synonym: "regulation of abscisic acid formation" EXACT [] +synonym: "regulation of abscisic acid synthesis" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0009688 ! abscisic acid biosynthetic process + +[Term] +id: GO:0010116 +name: positive regulation of abscisic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] +synonym: "activation of abscisic acid biosynthetic process" NARROW [] +synonym: "positive regulation of abscisic acid anabolism" EXACT [] +synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] +synonym: "positive regulation of abscisic acid formation" EXACT [] +synonym: "positive regulation of abscisic acid synthesis" EXACT [] +synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] +synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] +synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] +synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] +is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process + +[Term] +id: GO:0010117 +name: photoprotection +namespace: biological_process +def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0010118 +name: stomatal movement +namespace: biological_process +def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0010119 +name: regulation of stomatal movement +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0010118 ! stomatal movement + +[Term] +id: GO:0010120 +name: camalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] +synonym: "camalexin anabolism" EXACT [] +synonym: "camalexin biosynthesis" EXACT [] +synonym: "camalexin formation" EXACT [] +synonym: "camalexin synthesis" EXACT [] +xref: MetaCyc:CAMALEXIN-SYN +is_a: GO:0009700 ! indole phytoalexin biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0052317 ! camalexin metabolic process + +[Term] +id: GO:0010121 +name: arginine catabolic process to proline via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] +synonym: "arginine breakdown to proline via ornithine" EXACT [] +synonym: "arginine degradation to proline via ornithine" EXACT [] +xref: MetaCyc:ARGORNPROST-PWY +is_a: GO:0019493 ! arginine catabolic process to proline + +[Term] +id: GO:0010122 +name: arginine catabolic process to alanine via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] +synonym: "arginine breakdown to alanine via ornithine" EXACT [] +synonym: "arginine degradation to alanine via ornithine" EXACT [] +xref: MetaCyc:ARGORNPROST-PWY +is_a: GO:0006522 ! alanine metabolic process +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0010123 +name: acetate catabolic process to butyrate, ethanol, acetone and butanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] +synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] +xref: MetaCyc:CENTFERM-PWY +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0019654 ! acetate fermentation +is_a: GO:0043443 ! acetone metabolic process +is_a: GO:0045733 ! acetate catabolic process +is_a: GO:0071270 ! 1-butanol metabolic process + +[Term] +id: GO:0010124 +name: phenylacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] +synonym: "phenylacetate breakdown" EXACT [] +synonym: "phenylacetate catabolism" EXACT [] +synonym: "phenylacetate degradation" EXACT [] +xref: MetaCyc:PWY0-321 +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0010125 +name: mycothiol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] +synonym: "mycothiol anabolism" EXACT [] +synonym: "mycothiol biosynthesis" EXACT [] +synonym: "mycothiol formation" EXACT [] +synonym: "mycothiol synthesis" EXACT [] +xref: MetaCyc:PWY1G-0 +is_a: GO:0010126 ! mycothiol metabolic process +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0010126 +name: mycothiol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] +synonym: "mycothiol metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0010127 +name: mycothiol-dependent detoxification +namespace: biological_process +def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] +synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] +xref: MetaCyc:PWY1G-1 +xref: MetaCyc:PWY1G-170 +is_a: GO:0098754 ! detoxification + +[Term] +id: GO:0010128 +name: benzoate catabolic process via CoA ligation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] +synonym: "anaerobic benzoate breakdown" EXACT [] +synonym: "anaerobic benzoate catabolic process" EXACT [] +synonym: "anaerobic benzoate catabolism" EXACT [] +synonym: "anaerobic benzoate degradation" EXACT [] +xref: MetaCyc:PWY-283 +is_a: GO:0018875 ! anaerobic benzoate metabolic process +is_a: GO:0043639 ! benzoate catabolic process + +[Term] +id: GO:0010129 +name: anaerobic cyclohexane-1-carboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] +synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] +synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] +synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] +xref: MetaCyc:PWY-301 +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0010130 +name: anaerobic ethylbenzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] +synonym: "anaerobic ethylbenzene breakdown" EXACT [] +synonym: "anaerobic ethylbenzene catabolism" EXACT [] +synonym: "anaerobic ethylbenzene degradation" EXACT [] +xref: MetaCyc:PWY-481 +is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process + +[Term] +id: GO:0010131 +name: obsolete sucrose catabolic process, using invertase or sucrose synthase +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] +comment: This term was made obsolete because it describes two different routes of sucrose catabolism, both of which are represented by molecular functions. +synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] +synonym: "sucrose catabolic process, using invertase or sucrose synthase" EXACT [] +synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] +synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] +xref: MetaCyc:PWY-3801 +xref: MetaCyc:PWY-621 +is_obsolete: true +consider: GO:0004564 +consider: GO:0005987 +consider: GO:0016157 + +[Term] +id: GO:0010132 +name: dhurrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] +synonym: "dhurrin anabolism" EXACT [] +synonym: "dhurrin biosynthesis" EXACT [] +synonym: "dhurrin formation" EXACT [] +synonym: "dhurrin synthesis" EXACT [] +xref: MetaCyc:PWY-861 +is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:0010133 +name: proline catabolic process to glutamate +namespace: biological_process +alt_id: GO:0019494 +def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] +synonym: "proline breakdown to glutamate" EXACT [] +synonym: "proline degradation to glutamate" EXACT [] +synonym: "proline oxidation" RELATED [] +xref: MetaCyc:PROUT-PWY +xref: MetaCyc:PWY-4561 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006562 ! proline catabolic process + +[Term] +id: GO:0010134 +name: sulfate assimilation via adenylyl sulfate reduction +namespace: biological_process +def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] +synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] +xref: MetaCyc:SULFMETII-PWY +is_a: GO:0000103 ! sulfate assimilation +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0010135 +name: ureide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] +synonym: "ureide metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0010136 +name: ureide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] +synonym: "ureide breakdown" EXACT [] +synonym: "ureide catabolism" EXACT [] +synonym: "ureide degradation" EXACT [] +xref: MetaCyc:URDEGR-PWY +is_a: GO:0010135 ! ureide metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process + +[Term] +id: GO:0010137 +name: ureide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] +synonym: "ureide anabolism" EXACT [] +synonym: "ureide biosynthesis" EXACT [] +synonym: "ureide formation" EXACT [] +synonym: "ureide synthesis" EXACT [] +xref: MetaCyc:URSIN-PWY +is_a: GO:0010135 ! ureide metabolic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0010138 +name: pyrimidine ribonucleotide salvage +namespace: biological_process +def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] +xref: MetaCyc:PWY0-163 +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0032262 ! pyrimidine nucleotide salvage + +[Term] +id: GO:0010139 +name: pyrimidine deoxyribonucleotide salvage +namespace: biological_process +def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] +xref: MetaCyc:PWY0-181 +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0032262 ! pyrimidine nucleotide salvage + +[Term] +id: GO:0010140 +name: obsolete adenine, hypoxanthine and their nucleoside salvage +namespace: biological_process +def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] +comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. +synonym: "adenine, hypoxanthine and their nucleoside salvage" EXACT [] +is_obsolete: true +consider: GO:0006168 +consider: GO:0006169 +consider: GO:0006190 +consider: GO:0043103 + +[Term] +id: GO:0010141 +name: obsolete guanine, xanthine and their nucleoside salvage +namespace: biological_process +def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] +comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. +synonym: "guanine, xanthine and their nucleoside salvage" EXACT [] +is_obsolete: true +consider: GO:0006178 +consider: GO:0006179 +consider: GO:0006190 +consider: GO:0043103 + +[Term] +id: GO:0010142 +name: farnesyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] +synonym: "Ac-MVA pathway" NARROW [PMID:14517367] +synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] +synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] +synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] +synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] +synonym: "isoprenoid pathway" EXACT [] +xref: MetaCyc:PWY-922 +is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process +is_a: GO:1902767 ! isoprenoid biosynthetic process via mevalonate +relationship: part_of GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0010143 +name: cutin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] +synonym: "cutin anabolism" EXACT [] +synonym: "cutin biosynthesis" EXACT [] +synonym: "cutin formation" EXACT [] +synonym: "cutin synthesis" EXACT [] +xref: MetaCyc:PWY-321 +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010144 +name: pyridoxal phosphate biosynthetic process from pyridoxamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] +synonym: "pyridoxal 5'-phosphate salvage from pyridoxamine" EXACT [] +synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] +synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] +synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] +synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] +synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] +is_a: GO:0009443 ! pyridoxal 5'-phosphate salvage +is_a: GO:0042818 ! pyridoxamine metabolic process + +[Term] +id: GO:0010145 +name: fructan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] +synonym: "fructan metabolism" EXACT [] +synonym: "levan metabolic process" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0010146 +name: fructan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] +synonym: "fructan anabolism" EXACT [] +synonym: "fructan biosynthesis" EXACT [] +synonym: "fructan formation" EXACT [] +synonym: "fructan synthesis" EXACT [] +synonym: "levan biosynthesis" EXACT [] +synonym: "levan biosynthetic process" EXACT [] +xref: MetaCyc:PWY-822 +is_a: GO:0010145 ! fructan metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0010147 +name: fructan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] +synonym: "fructan breakdown" EXACT [] +synonym: "fructan catabolism" EXACT [] +synonym: "fructan degradation" EXACT [] +synonym: "levan catabolic process" EXACT [] +synonym: "levan catabolism" EXACT [] +xref: MetaCyc:PWY-862 +is_a: GO:0010145 ! fructan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0010148 +name: transpiration +namespace: biological_process +def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] +xref: Wikipedia:Transpiration +is_a: GO:0006833 ! water transport + +[Term] +id: GO:0010149 +name: obsolete senescence +namespace: biological_process +def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819] +comment: This term was made obsolete because its name is ambiguous and it is covered by the two more specific terms: 'organ senescence ; GO:0010260' and 'cell aging ; GO:0007569'. +synonym: "senescence" EXACT [] +xref: Wikipedia:Senescence +is_obsolete: true + +[Term] +id: GO:0010150 +name: leaf senescence +namespace: biological_process +def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] +is_a: GO:0090693 ! plant organ senescence +relationship: part_of GO:0048366 ! leaf development + +[Term] +id: GO:0010151 +name: chloroplast elongation +namespace: biological_process +def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] +is_a: GO:0009658 ! chloroplast organization + +[Term] +id: GO:0010152 +name: pollen maturation +namespace: biological_process +def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0010153 +name: obsolete polar cell elongation +namespace: biological_process +def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] +comment: This term was made obsolete because it did not represent a process discrete from its sibling terms. +synonym: "polar cell elongation" EXACT [] +synonym: "polarity-dependent cell elongation" NARROW [] +is_obsolete: true +consider: GO:0042814 +consider: GO:0042815 + +[Term] +id: GO:0010154 +name: fruit development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0010155 +name: regulation of proton transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1902600 ! proton transmembrane transport + +[Term] +id: GO:0010156 +name: obsolete sporocyte morphogenesis +namespace: biological_process +def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] +comment: This term was made obsolete because it was incorrectly defined. +synonym: "sporocyte morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0048533 + +[Term] +id: GO:0010157 +name: response to chlorate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010158 +name: abaxial cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] +is_a: GO:0001708 ! cell fate specification + +[Term] +id: GO:0010159 +name: specification of animal organ position +namespace: biological_process +def: "The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ." [GOC:curators] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0010160 +name: formation of animal organ boundary +namespace: biological_process +alt_id: GO:0048862 +def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] +synonym: "organ boundary specification" EXACT [] +is_a: GO:0003002 ! regionalization +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0048645 ! animal organ formation + +[Term] +id: GO:0010161 +name: red light signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] +synonym: "red light phototransduction" EXACT [GOC:signaling] +synonym: "red light signal transduction" EXACT [GOC:signaling] +synonym: "red light signalling pathway" EXACT [] +is_a: GO:0010017 ! red or far-red light signaling pathway +is_a: GO:0071491 ! cellular response to red light + +[Term] +id: GO:0010162 +name: seed dormancy process +namespace: biological_process +def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors." [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009] +synonym: "seed dormancy" RELATED [] +xref: Wikipedia:Seed#Seed_dormancy_and_protection +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022611 ! dormancy process +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0010431 ! seed maturation + +[Term] +id: GO:0010164 +name: response to cesium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] +synonym: "response to cesium" EXACT [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010165 +name: response to X-ray +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] +synonym: "response to X-ray radiation stimulus" EXACT [] +is_a: GO:0010212 ! response to ionizing radiation + +[Term] +id: GO:0010166 +name: wax metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] +synonym: "wax metabolism" EXACT [] +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:0010167 +name: response to nitrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010168 +name: ER body +namespace: cellular_component +def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] +synonym: "endoplasmic reticulum body" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0010169 +name: thioglucosidase complex +namespace: cellular_component +def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] +synonym: "myrosinase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0010170 +name: glucose-1-phosphate adenylyltransferase complex +namespace: cellular_component +def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902503 ! adenylyltransferase complex + +[Term] +id: GO:0010171 +name: body morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0010172 +name: embryonic body morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems] +is_a: GO:0010171 ! body morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0010174 +name: nucleoside transmembrane transporter activity, against a concentration gradient +namespace: molecular_function +def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] +synonym: "concentrative nucleoside transporter activity" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0010176 +name: homogentisate phytyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521] +xref: KEGG_REACTION:R07500 +xref: MetaCyc:RXN-2541 +xref: RHEA:37975 +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010177 +name: 2-(2'-methylthio)ethylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+." [MetaCyc:RXN-2202] +synonym: "methylthioalkylmalate synthase activity" BROAD [MetaCyc:RXN-2202] +xref: EC:2.3.3.17 +xref: MetaCyc:RXN-2202 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0010178 +name: IAA-amino acid conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0010179 +name: IAA-Ala conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981] +xref: MetaCyc:RXN-2981 +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010180 +name: thioglucosidase binding +namespace: molecular_function +def: "Binding to a thioglucosidase enzyme." [GOC:tb] +synonym: "myrosinase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0010181 +name: FMN binding +namespace: molecular_function +def: "Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] +synonym: "flavin mononucleotide binding" EXACT [] +is_a: GO:0032553 ! ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0010182 +name: sugar mediated signaling pathway +namespace: biological_process +def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] +synonym: "sugar mediated signalling" EXACT [] +is_a: GO:0009756 ! carbohydrate mediated signaling + +[Term] +id: GO:0010183 +name: pollen tube guidance +namespace: biological_process +def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] +is_a: GO:0022414 ! reproductive process +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0048868 ! pollen tube development + +[Term] +id: GO:0010184 +name: cytokinin transport +namespace: biological_process +def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr] +is_a: GO:0009914 ! hormone transport + +[Term] +id: GO:0010185 +name: regulation of cellular defense response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] +synonym: "regulation of cellular defence response" EXACT [] +is_a: GO:0031347 ! regulation of defense response +relationship: regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0010186 +name: positive regulation of cellular defense response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] +synonym: "activation of cellular defense response" NARROW [] +synonym: "positive regulation of cellular defence response" EXACT [] +synonym: "stimulation of cellular defense response" NARROW [] +synonym: "up regulation of cellular defense response" EXACT [] +synonym: "up-regulation of cellular defense response" EXACT [] +synonym: "upregulation of cellular defense response" EXACT [] +is_a: GO:0010185 ! regulation of cellular defense response +is_a: GO:0031349 ! positive regulation of defense response +relationship: positively_regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0010187 +name: negative regulation of seed germination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb] +synonym: "down regulation of seed germination" EXACT [] +synonym: "down-regulation of seed germination" EXACT [] +synonym: "downregulation of seed germination" EXACT [] +synonym: "inhibition of seed germination" NARROW [] +is_a: GO:0010029 ! regulation of seed germination +is_a: GO:0048581 ! negative regulation of post-embryonic development +relationship: negatively_regulates GO:0009845 ! seed germination + +[Term] +id: GO:0010188 +name: response to microbial phytotoxin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] +is_a: GO:0009636 ! response to toxic substance + +[Term] +id: GO:0010189 +name: vitamin E biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] +synonym: "alpha-tocopherol biosynthesis" NARROW [] +synonym: "alpha-tocopherol biosynthetic process" NARROW [] +synonym: "tocopherol biosynthesis" EXACT [] +synonym: "tocopherol biosynthetic process" EXACT [] +synonym: "vitamin E anabolism" EXACT [] +synonym: "vitamin E biosynthesis" EXACT [] +synonym: "vitamin E formation" EXACT [] +synonym: "vitamin E synthesis" EXACT [] +xref: MetaCyc:PWY-1422 +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042360 ! vitamin E metabolic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0010190 +name: cytochrome b6f complex assembly +namespace: biological_process +def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] +synonym: "cytochrome b6f complex biogenesis" EXACT [] +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0010191 +name: mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] +subset: goslim_pir +synonym: "mucilage metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0010192 +name: mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] +synonym: "mucilage anabolism" EXACT [] +synonym: "mucilage biosynthesis" EXACT [] +synonym: "mucilage formation" EXACT [] +synonym: "mucilage synthesis" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0010193 +name: response to ozone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010194 +name: obsolete microRNA metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] +comment: This term was made obsolete because it implies further processing of an end product rather than its production. +synonym: "microRNA metabolic process" EXACT [] +is_obsolete: true +replaced_by: GO:0035196 + +[Term] +id: GO:0010195 +name: obsolete microRNA biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] +comment: This term was made obsolete because it represents a process that is not known to occur. +synonym: "microRNA anabolism" EXACT [] +synonym: "microRNA biosynthesis" EXACT [] +synonym: "microRNA biosynthetic process" EXACT [] +synonym: "microRNA formation" EXACT [] +synonym: "microRNA synthesis" EXACT [] +synonym: "miRNA biosynthesis" EXACT [] +synonym: "miRNA biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0035196 + +[Term] +id: GO:0010196 +name: nonphotochemical quenching +namespace: biological_process +def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783, PMID:10938857] +is_a: GO:1990066 ! energy quenching + +[Term] +id: GO:0010197 +name: polar nucleus fusion +namespace: biological_process +def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] +is_a: GO:0000741 ! karyogamy +relationship: part_of GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0010198 +name: synergid death +namespace: biological_process +alt_id: GO:0048470 +def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] +synonym: "synergid cell death" EXACT [] +synonym: "synergid degeneration" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010623 ! programmed cell death involved in cell development +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0010199 +name: organ boundary specification between lateral organs and the meristem +namespace: biological_process +def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] +is_a: GO:0090691 ! formation of plant organ boundary + +[Term] +id: GO:0010200 +name: response to chitin +namespace: biological_process +def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010201 +name: response to continuous far red light stimulus by the high-irradiance response system +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0010218 ! response to far red light + +[Term] +id: GO:0010202 +name: response to low fluence red light stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0009645 ! response to low light intensity stimulus +is_a: GO:0010114 ! response to red light + +[Term] +id: GO:0010203 +name: response to very low fluence red light stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] +is_a: GO:0010114 ! response to red light +is_a: GO:0055122 ! response to very low light intensity stimulus + +[Term] +id: GO:0010205 +name: photoinhibition +namespace: biological_process +def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] +synonym: "photosystem II inhibition" BROAD [] +xref: Wikipedia:Photoinhibition +is_a: GO:0009644 ! response to high light intensity +is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction +relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain + +[Term] +id: GO:0010206 +name: photosystem II repair +namespace: biological_process +def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition." [GOC:sm] +is_a: GO:0030091 ! protein repair +relationship: part_of GO:0009765 ! photosynthesis, light harvesting + +[Term] +id: GO:0010207 +name: photosystem II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms." [GOC:aa, GOC:pz] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0010208 +name: pollen wall assembly +namespace: biological_process +def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] +synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0045229 ! external encapsulating structure organization +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0010209 +name: vacuolar sorting signal binding +namespace: molecular_function +def: "Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0010210 +name: IAA-Phe conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr] +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010211 +name: IAA-Leu conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982] +xref: MetaCyc:RXN-2982 +is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity + +[Term] +id: GO:0010212 +name: response to ionizing radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] +synonym: "response to ionising radiation" EXACT [] +synonym: "response to ionizing radiation stimulus" EXACT [] +is_a: GO:0009314 ! response to radiation + +[Term] +id: GO:0010213 +name: non-photoreactive DNA repair +namespace: biological_process +def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] +synonym: "light-independent DNA repair" EXACT [GOC:syr] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0010214 +name: seed coat development +namespace: biological_process +def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010215 +name: cellulose microfibril organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730] +synonym: "cellulose microfibril organisation" EXACT [] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0071668 ! plant-type cell wall assembly + +[Term] +id: GO:0010216 +name: maintenance of DNA methylation +namespace: biological_process +def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0010217 +name: cellular aluminum ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah] +synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0055079 ! aluminum ion homeostasis + +[Term] +id: GO:0010218 +name: response to far red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] +synonym: "response to far red light stimulus" EXACT [] +is_a: GO:0009639 ! response to red or far red light + +[Term] +id: GO:0010219 +name: regulation of vernalization response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010220 +name: positive regulation of vernalization response +namespace: biological_process +def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +synonym: "activation of vernalization response" NARROW [] +synonym: "stimulation of vernalization response" NARROW [] +synonym: "up regulation of vernalization response" EXACT [] +synonym: "up-regulation of vernalization response" EXACT [] +synonym: "upregulation of vernalization response" EXACT [] +is_a: GO:0010219 ! regulation of vernalization response +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010221 +name: negative regulation of vernalization response +namespace: biological_process +def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] +synonym: "down regulation of vernalization response" EXACT [] +synonym: "down-regulation of vernalization response" EXACT [] +synonym: "downregulation of vernalization response" EXACT [] +synonym: "inhibition of vernalization response" NARROW [] +is_a: GO:0010219 ! regulation of vernalization response +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0010048 ! vernalization response + +[Term] +id: GO:0010222 +name: stem vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0010223 +name: secondary shoot formation +namespace: biological_process +def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] +synonym: "auxiliary shoot formation" RELATED [] +synonym: "axillary shoot formation" RELATED [] +synonym: "axillary shoot system formation" EXACT [] +synonym: "shoot branching" RELATED [] +is_a: GO:0001763 ! morphogenesis of a branching structure +is_a: GO:0010346 ! shoot axis formation + +[Term] +id: GO:0010224 +name: response to UV-B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] +synonym: "response to medium wave ultraviolet light stimulus" EXACT [] +synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV-B light stimulus" EXACT [] +synonym: "response to UV-B radiation stimulus" EXACT [] +synonym: "response to UVB light stimulus" EXACT [] +synonym: "response to UVB radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0010225 +name: response to UV-C +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb] +synonym: "response to germicidal ultraviolet light stimulus" EXACT [] +synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] +synonym: "response to shortwave ultraviolet light stimulus" EXACT [] +synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] +synonym: "response to UV-C light stimulus" EXACT [] +synonym: "response to UV-C radiation stimulus" EXACT [] +synonym: "response to UVC light stimulus" EXACT [] +synonym: "response to UVC radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0010226 +name: response to lithium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010227 +name: floral organ abscission +namespace: biological_process +def: "The controlled shedding of floral organs." [GOC:PO_curators, PMID:12972671, PO:0025395] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009838 ! abscission +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0010228 +name: vegetative to reproductive phase transition of meristem +namespace: biological_process +def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] +synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] +synonym: "flowering" RELATED [] +synonym: "transition from vegetative to reproductive phase" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0009791 ! post-embryonic development +relationship: part_of GO:0048608 ! reproductive structure development + +[Term] +id: GO:0010229 +name: inflorescence development +namespace: biological_process +def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0090567 ! reproductive shoot system development + +[Term] +id: GO:0010230 +name: alternative respiration +namespace: biological_process +def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] +is_a: GO:0009060 ! aerobic respiration + +[Term] +id: GO:0010231 +name: maintenance of seed dormancy +namespace: biological_process +def: "Any process that maintains a seed in a dormant state." [ISBN:9781405139830, PMID:9580097] +is_a: GO:0010162 ! seed dormancy process +is_a: GO:0097437 ! maintenance of dormancy + +[Term] +id: GO:0010232 +name: vascular transport +namespace: biological_process +def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0006810 ! transport + +[Term] +id: GO:0010233 +name: phloem transport +namespace: biological_process +def: "The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues." [GOC:sm, PMID:19025382] +is_a: GO:0010232 ! vascular transport + +[Term] +id: GO:0010234 +name: anther wall tapetum cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] +synonym: "tapetal cell fate specification" BROAD [GOC:tb] +is_a: GO:0001708 ! cell fate specification +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0048657 ! anther wall tapetum cell differentiation + +[Term] +id: GO:0010235 +name: guard mother cell cytokinesis +namespace: biological_process +def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] +synonym: "guard mother cell division" EXACT [] +is_a: GO:0000911 ! cytokinesis by cell plate formation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010236 +name: plastoquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] +synonym: "plastoquinone anabolism" EXACT [] +synonym: "plastoquinone biosynthesis" EXACT [] +synonym: "plastoquinone formation" EXACT [] +synonym: "plastoquinone synthesis" EXACT [] +xref: MetaCyc:PWY-1581 +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0010238 +name: response to proline +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:0010239 +name: chloroplast mRNA processing +namespace: biological_process +def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] +is_a: GO:0006397 ! mRNA processing +is_a: GO:0031425 ! chloroplast RNA processing + +[Term] +id: GO:0010240 +name: plastid pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] +synonym: "dehydrogenase complex" BROAD [] +is_a: GO:0045254 ! pyruvate dehydrogenase complex +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0010241 +name: ent-kaurene oxidation to kaurenoic acid +namespace: biological_process +def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [GOC:tb] +comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions. +synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT [] +synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT [] +synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT [] +is_a: GO:0033331 ! ent-kaurene metabolic process + +[Term] +id: GO:0010242 +name: oxygen evolving activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] +synonym: "photosynthetic water oxidation" EXACT [] +xref: EC:1.10.3.9 +xref: MetaCyc:PSII-RXN +xref: MetaCyc:RXN0-5265 +xref: RHEA:36359 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0010243 +name: response to organonitrogen compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [PMID:9869419] +synonym: "response to organic nitrogen" EXACT [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0010244 +name: response to low fluence blue light stimulus by blue low-fluence system +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] +synonym: "response to low fluence blue light" BROAD [] +synonym: "response to low fluence blue light by blf system" EXACT [] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009645 ! response to low light intensity stimulus + +[Term] +id: GO:0010245 +name: radial microtubular system formation +namespace: biological_process +def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0010246 +name: rhamnogalacturonan I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] +synonym: "rhamnogalacturonan I anabolism" EXACT [] +synonym: "rhamnogalacturonan I biosynthesis" EXACT [] +synonym: "rhamnogalacturonan I formation" EXACT [] +synonym: "rhamnogalacturonan I synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0010395 ! rhamnogalacturonan I metabolic process + +[Term] +id: GO:0010247 +name: detection of phosphate ion +namespace: biological_process +def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] +synonym: "phosphate ion detection" EXACT [] +synonym: "phosphate ion perception" RELATED [] +synonym: "phosphate ion sensing" RELATED [] +is_a: GO:0009593 ! detection of chemical stimulus + +[Term] +id: GO:0010248 +name: establishment or maintenance of transmembrane electrochemical gradient +namespace: biological_process +def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm] +is_a: GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0010249 +name: auxin conjugate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] +synonym: "auxin conjugate metabolism" EXACT [] +is_a: GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0010250 +name: S-methylmethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] +synonym: "S-methylmethionine anabolism" EXACT [] +synonym: "S-methylmethionine biosynthesis" EXACT [] +synonym: "S-methylmethionine formation" EXACT [] +synonym: "S-methylmethionine synthesis" EXACT [] +is_a: GO:0033477 ! S-methylmethionine metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0010252 +name: auxin homeostasis +namespace: biological_process +def: "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [PMID:22504182] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0010253 +name: UDP-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] +synonym: "UDP-rhamnose anabolism" EXACT [] +synonym: "UDP-rhamnose biosynthesis" EXACT [] +synonym: "UDP-rhamnose formation" EXACT [] +synonym: "UDP-rhamnose synthesis" EXACT [] +xref: MetaCyc:PWY-3261 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033478 ! UDP-rhamnose metabolic process + +[Term] +id: GO:0010254 +name: nectary development +namespace: biological_process +def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010255 +name: glucose mediated signaling pathway +namespace: biological_process +def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] +synonym: "glucose mediated signalling" EXACT [] +is_a: GO:0009757 ! hexose mediated signaling +relationship: part_of GO:0071333 ! cellular response to glucose stimulus + +[Term] +id: GO:0010256 +name: endomembrane system organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] +subset: goslim_drosophila +synonym: "endomembrane organization" EXACT [] +synonym: "endomembrane system organisation" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0010257 +name: NADH dehydrogenase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0010258 +name: NADH dehydrogenase complex (plastoquinone) assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] +is_a: GO:0010257 ! NADH dehydrogenase complex assembly +is_a: GO:0010275 ! NAD(P)H dehydrogenase complex assembly + +[Term] +id: GO:0010259 +name: multicellular organism aging +namespace: biological_process +def: "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] +is_a: GO:0007275 ! multicellular organism development +is_a: GO:0007568 ! aging + +[Term] +id: GO:0010260 +name: animal organ senescence +namespace: biological_process +alt_id: GO:0010261 +def: "The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb] +is_a: GO:0007568 ! aging +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0010262 +name: somatic embryogenesis +namespace: biological_process +def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] +is_a: GO:0009793 ! embryo development ending in seed dormancy +is_a: GO:0031099 ! regeneration + +[Term] +id: GO:0010263 +name: tricyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] +synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] +synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process +is_a: GO:0016104 ! triterpenoid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0010264 +name: myo-inositol hexakisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538] +synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] +synonym: "myo-inositol hexakisphosphate formation" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] +synonym: "phytate biosynthesis" EXACT [] +synonym: "phytate biosynthetic process" EXACT [] +is_a: GO:0032958 ! inositol phosphate biosynthetic process +is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process + +[Term] +id: GO:0010265 +name: SCF complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0010266 +name: response to vitamin B1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] +synonym: "response to thiamin" EXACT [] +synonym: "response to thiamine" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0010267 +name: primary ta-siRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary ta-siRNA transcript into a mature ta-siRNA molecule. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] +synonym: "production of small RNA involved in gene silencing by RNA" NARROW [] +synonym: "production of ta-siRNAs involved in RNA interference" EXACT [] +synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah] +synonym: "ta-siRNA processing" RELATED [] +is_a: GO:0030422 ! production of siRNA involved in RNA interference + +[Term] +id: GO:0010268 +name: brassinosteroid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0010269 +name: response to selenium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0010270 +name: photosystem II oxygen evolving complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ." [GOC:aa, PMID:16282331] +synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] +is_a: GO:0010207 ! photosystem II assembly + +[Term] +id: GO:0010271 +name: regulation of chlorophyll catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] +is_a: GO:0090056 ! regulation of chlorophyll metabolic process +is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process +relationship: regulates GO:0015996 ! chlorophyll catabolic process + +[Term] +id: GO:0010272 +name: response to silver ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010273 +name: detoxification of copper ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [GOC:kmv, PMID:16367966] +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:1990169 ! stress response to copper ion + +[Term] +id: GO:0010274 +name: hydrotropism +namespace: biological_process +def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] +xref: Wikipedia:Hydrotropism +is_a: GO:0009606 ! tropism + +[Term] +id: GO:0010275 +name: NAD(P)H dehydrogenase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] +synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0010276 +name: phytol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [RHEA:38055] +xref: EC:2.7.1.182 +xref: MetaCyc:RXN-7683 +xref: RHEA:38055 +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0010277 +name: chlorophyllide a oxygenase [overall] activity +namespace: molecular_function +alt_id: GO:0046407 +def: "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] +comment: This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'. +synonym: "CAO activity" BROAD [EC:1.13.12.14] +synonym: "chlorophyll a oxygenation activity" EXACT [] +synonym: "chlorophyll b synthesis activity" EXACT [] +synonym: "chlorophyll-b synthesis activity" RELATED [EC:1.13.12.14] +synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" RELATED [EC:1.13.12.14] +synonym: "chlorophyllide-a oxygenation activity" RELATED [EC:1.13.12.14] +xref: EC:1.14.13.122 +xref: RHEA:30359 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0010278 +name: chloroplast outer membrane translocon +namespace: cellular_component +def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0010279 +name: indole-3-acetic acid amido synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623] +synonym: "IAA amido synthetase activity" EXACT [] +synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad] +synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0010280 +name: UDP-L-rhamnose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918] +synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] +xref: MetaCyc:RXN-5482 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0010282 +name: senescence-associated vacuole +namespace: cellular_component +def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] +synonym: "senescence associated vacuole" EXACT [] +is_a: GO:0000323 ! lytic vacuole +is_a: GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0010283 +name: pinoresinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] +xref: MetaCyc:RXN-8678 +xref: MetaCyc:RXN-8683 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010284 +name: lariciresinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] +xref: MetaCyc:RXN-8679 +xref: MetaCyc:RXN-8684 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010285 +name: L,L-diaminopimelate aminotransferase activity +namespace: molecular_function +alt_id: GO:0043742 +def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+)." [EC:2.6.1.83, RHEA:23988] +synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] +synonym: "LL-DAP aminotransferase activity" RELATED [EC:2.6.1.83] +synonym: "LL-DAP-AT activity" RELATED [EC:2.6.1.83] +synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] +synonym: "LL-diaminopimelate transaminase activity" RELATED [EC:2.6.1.83] +xref: EC:2.6.1.83 +xref: KEGG_REACTION:R07613 +xref: MetaCyc:RXN-7737 +xref: RHEA:23988 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0010286 +name: heat acclimation +namespace: biological_process +def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] +synonym: "thermotolerance" RELATED [GOC:tb] +is_a: GO:0009408 ! response to heat + +[Term] +id: GO:0010287 +name: plastoglobule +namespace: cellular_component +alt_id: GO:0010502 +def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] +synonym: "PG" EXACT [] +synonym: "plastoglobuli" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0010288 +name: response to lead ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0010289 +name: homogalacturonan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] +xref: MetaCyc:PWY-1061 +is_a: GO:0010394 ! homogalacturonan metabolic process +is_a: GO:0052325 ! cell wall pectin biosynthetic process + +[Term] +id: GO:0010290 +name: chlorophyll catabolite transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other." [PMID:9681016] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0010291 +name: carotene beta-ring hydroxylase activity +namespace: molecular_function +alt_id: GO:0042411 +def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736] +synonym: "beta-carotene hydroxylase activity" NARROW [] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0010292 +name: GTP:GDP antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] +is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0010293 +name: abscisic aldehyde oxidase activity +namespace: molecular_function +alt_id: GO:0033725 +def: "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+)." [EC:1.2.3.14, RHEA:20529] +synonym: "AAO3" RELATED [EC:1.2.3.14] +synonym: "abscisic-aldehyde oxidase activity" RELATED [EC:1.2.3.14] +synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.14] +synonym: "AOdelta" RELATED [EC:1.2.3.14] +xref: EC:1.2.3.14 +xref: KEGG_REACTION:R06957 +xref: MetaCyc:1.2.3.14-RXN +xref: RHEA:20529 +is_a: GO:0018488 ! aryl-aldehyde oxidase activity + +[Term] +id: GO:0010294 +name: abscisic acid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] +xref: MetaCyc:RXN-8155 +xref: RHEA:31031 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0010295 +name: (+)-abscisic acid 8'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+)." [EC:1.14.14.137, RHEA:12897] +synonym: "(+)-ABA 8'-hydroxylase activity" RELATED [EC:1.14.14.137] +synonym: "ABA 8'-hydroxylase activity" RELATED [EC:1.14.14.137] +synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] +synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" RELATED [EC:1.14.14.137] +synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] +xref: EC:1.14.14.137 +xref: KEGG_REACTION:R07202 +xref: MetaCyc:1.14.13.93-RXN +xref: RHEA:12897 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0010296 +name: prenylcysteine methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [PMID:16870359, RHEA:48520] +xref: MetaCyc:RXN-8409 +xref: RHEA:48520 +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0010297 +name: heteropolysaccharide binding +namespace: molecular_function +def: "Binding to a heteropolysaccharide, a glycan composed of more than one type of monosaccharide residue." [PMID:16640603] +synonym: "heteroglycan binding" EXACT [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0010298 +name: dihydrocamalexic acid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671] +xref: MetaCyc:RXN-8275 +xref: RHEA:34807 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0010299 +name: detoxification of cobalt ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:0032025 ! response to cobalt ion + +[Term] +id: GO:0010301 +name: xanthoxin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0033710 +def: "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH." [EC:1.1.1.288, RHEA:12548] +synonym: "ABA2" RELATED [EC:1.1.1.288] +synonym: "xanthoxin oxidase activity" RELATED [EC:1.1.1.288] +synonym: "xanthoxin:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.288] +xref: EC:1.1.1.288 +xref: KEGG_REACTION:R06954 +xref: MetaCyc:1.1.1.288-RXN +xref: RHEA:12548 +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0010303 +name: limit dextrinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] +synonym: "amylopectin-1,6-glucosidase activity" RELATED [EC:3.2.1.142] +synonym: "dextrin alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.142] +synonym: "R-enzyme" RELATED [EC:3.2.1.142] +xref: EC:3.2.1.142 +xref: MetaCyc:3.2.1.10-RXN +xref: MetaCyc:3.2.1.142-RXN +xref: MetaCyc:RXN-1824 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0010304 +name: PSII associated light-harvesting complex II catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880] +synonym: "LHCII catabolism" RELATED [] +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0010305 +name: leaf vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0010306 +name: rhamnogalacturonan II biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] +is_a: GO:0010396 ! rhamnogalacturonan II metabolic process +is_a: GO:0052325 ! cell wall pectin biosynthetic process + +[Term] +id: GO:0010307 +name: acetylglutamate kinase regulator activity +namespace: molecular_function +def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0010308 +name: acireductone dioxygenase (Ni2+-requiring) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14161] +synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" RELATED [EC:1.13.11.53] +synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] +synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] +synonym: "ARD activity" RELATED [EC:1.13.11.53] +synonym: "E-2 activity" RELATED [EC:1.13.11.53] +xref: EC:1.13.11.53 +xref: KEGG_REACTION:R07363 +xref: MetaCyc:R146-RXN +xref: RHEA:14161 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010309 +name: acireductone dioxygenase [iron(II)-requiring] activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24504] +synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] +synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" RELATED [EC:1.13.11.54] +synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] +synonym: "aci-reductone dioxygenase" BROAD [] +synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] +synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] +synonym: "ARD'" RELATED [] +synonym: "ARD1" RELATED [] +synonym: "E-2'" RELATED [] +xref: EC:1.13.11.54 +xref: KEGG_REACTION:R07364 +xref: MetaCyc:R147-RXN +xref: Reactome:R-HSA-1237119 "Acireductone is oxidized to MOB" +xref: RHEA:24504 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010310 +name: regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] +synonym: "regulation of hydrogen peroxide metabolism" EXACT [] +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process +relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010311 +name: lateral root formation +namespace: biological_process +alt_id: GO:0010386 +def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators, PMID:17259263] +synonym: "lateral root primordium development" EXACT [] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:1905393 ! plant organ formation +relationship: part_of GO:0010102 ! lateral root morphogenesis + +[Term] +id: GO:0010312 +name: detoxification of zinc ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] +is_a: GO:0098754 ! detoxification +relationship: part_of GO:1990359 ! stress response to zinc ion + +[Term] +id: GO:0010313 +name: phytochrome binding +namespace: molecular_function +def: "Binding to a phytochrome." [PMID:15486102] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0010314 +name: phosphatidylinositol-5-phosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] +is_a: GO:1901981 ! phosphatidylinositol phosphate binding + +[Term] +id: GO:0010315 +name: auxin efflux +namespace: biological_process +def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators, PMID:16990790] +synonym: "auxin export" EXACT [] +is_a: GO:0010928 ! regulation of auxin mediated signaling pathway +is_a: GO:0060918 ! auxin transport + +[Term] +id: GO:0010316 +name: pyrophosphate-dependent phosphofructokinase complex +namespace: cellular_component +def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] +subset: goslim_pir +synonym: "PFK complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0010317 +name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex +namespace: cellular_component +def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] +synonym: "PFK complex, alpha-subunit" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex + +[Term] +id: GO:0010318 +name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex +namespace: cellular_component +def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] +synonym: "PFK complex, beta-subunit" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex + +[Term] +id: GO:0010319 +name: stromule +namespace: cellular_component +def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] +synonym: "Stroma-filled tubule" RELATED [] +xref: Wikipedia:Stromule +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0010320 +name: obsolete arginine/lysine endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] +comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. +synonym: "arginine/lysine endopeptidase activity" EXACT [] +is_obsolete: true +consider: GO:0004175 +consider: GO:0004197 + +[Term] +id: GO:0010321 +name: regulation of vegetative phase change +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0010050 ! vegetative phase change + +[Term] +id: GO:0010322 +name: regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] +synonym: "regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway + +[Term] +id: GO:0010323 +name: negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] +synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] +synonym: "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway + +[Term] +id: GO:0010324 +name: membrane invagination +namespace: biological_process +alt_id: GO:1902534 +def: "The infolding of a membrane." [GOC:tb] +subset: goslim_yeast +synonym: "single-organism membrane invagination" RELATED [] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0010325 +name: raffinose family oligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] +synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] +is_a: GO:0009312 ! oligosaccharide biosynthetic process + +[Term] +id: GO:0010326 +name: methionine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid." [MetaCyc:RXN-2201, PMID:17056707] +xref: MetaCyc:RXN-2201 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0010327 +name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] +synonym: "hexenol acetyltransferase" RELATED [] +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0010328 +name: auxin influx transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] +synonym: "auxin influx facilitator" RELATED [] +is_a: GO:0080161 ! auxin transmembrane transporter activity + +[Term] +id: GO:0010329 +name: auxin efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] +synonym: "auxin efflux carrier" RELATED [] +synonym: "auxin efflux facilitator" RELATED [] +is_a: GO:0080161 ! auxin transmembrane transporter activity + +[Term] +id: GO:0010330 +name: cellulose synthase complex +namespace: cellular_component +def: "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238, PMID:18485800, PMID:21307367] +synonym: "CESA complex" EXACT [] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0010331 +name: gibberellin binding +namespace: molecular_function +def: "Binding to a gibberellin, a plant hormone that regulates aspects of plant growth." [GOC:tair_curators] +synonym: "gibberellic acid receptor" RELATED [] +synonym: "gibberellin receptor" RELATED [] +is_a: GO:0019840 ! isoprenoid binding +is_a: GO:0042562 ! hormone binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0010332 +name: response to gamma radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators] +synonym: "response to gamma ray" RELATED [] +synonym: "response to gamma-ray photon" RELATED [] +is_a: GO:0010212 ! response to ionizing radiation + +[Term] +id: GO:0010333 +name: terpene synthase activity +namespace: molecular_function +def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [EC:4.2.3.-, GOC:tair_curators] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0010334 +name: sesquiterpene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [EC:4.2.3.-, GOC:tair_curators] +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0010335 +name: response to non-ionic osmotic stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] +is_a: GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0010336 +name: gibberellic acid homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] +synonym: "gibberellin homeostasis" BROAD [] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0010337 +name: regulation of salicylic acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] +synonym: "regulation of salicylic acid metabolism" RELATED [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +relationship: regulates GO:0009696 ! salicylic acid metabolic process + +[Term] +id: GO:0010338 +name: leaf formation +namespace: biological_process +def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] +is_a: GO:0099402 ! plant organ development +is_a: GO:1905393 ! plant organ formation +relationship: part_of GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0010339 +name: external side of cell wall +namespace: cellular_component +def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005618 ! cell wall +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0010340 +name: carboxyl-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0010341 +name: gibberellin carboxyl-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester." [PMID:17220201] +is_a: GO:0010340 ! carboxyl-O-methyltransferase activity + +[Term] +id: GO:0010342 +name: endosperm cellularization +namespace: biological_process +def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] +synonym: "cellularization of endosperm" EXACT [] +is_a: GO:0007349 ! cellularization + +[Term] +id: GO:0010343 +name: singlet oxygen-mediated programmed cell death +namespace: biological_process +def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:17075038] +synonym: "light-dependent programmed cell death" BROAD [] +synonym: "programmed cell death in response to singlet oxygen" EXACT [] +is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species +relationship: part_of GO:0071452 ! cellular response to singlet oxygen + +[Term] +id: GO:0010344 +name: seed oilbody biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495] +synonym: "oleosome biogenesis" RELATED [] +synonym: "seed oil body organization" EXACT [] +synonym: "spherosome biogenesis" RELATED [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0044085 ! cellular component biogenesis +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010345 +name: suberin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] +xref: MetaCyc:PWY-1121 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process + +[Term] +id: GO:0010346 +name: shoot axis formation +namespace: biological_process +def: "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] +synonym: "shoot formation" RELATED [] +is_a: GO:1905393 ! plant organ formation +relationship: part_of GO:0010016 ! shoot system morphogenesis + +[Term] +id: GO:0010347 +name: L-galactose-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] +xref: MetaCyc:RXNQT-4142 +xref: RHEA:26349 +is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity + +[Term] +id: GO:0010348 +name: lithium:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] +synonym: "lithium:hydrogen antiporter activity" EXACT [] +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0010349 +name: L-galactose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629, RHEA:31559] +synonym: "L-galactose 1-dehydrogenase activity" RELATED [] +xref: EC:1.1.1.316 +xref: MetaCyc:RXN-1884 +xref: RHEA:31559 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010350 +name: cellular response to magnesium starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0010351 +name: lithium ion transport +namespace: biological_process +def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011] +synonym: "lithium transport" EXACT [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0010352 +name: lithium ion export across the plasma membrane +namespace: biological_process +def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] +synonym: "lithium export" EXACT [] +synonym: "lithium ion efflux" RELATED [] +synonym: "lithium ion export" RELATED [] +is_a: GO:0010351 ! lithium ion transport +is_a: GO:0070839 ! metal ion export +is_a: GO:0098662 ! inorganic cation transmembrane transport +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0010353 +name: response to trehalose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] +synonym: "response to trehalose stimulus" EXACT [GOC:dos] +is_a: GO:0034285 ! response to disaccharide + +[Term] +id: GO:0010354 +name: homogentisate prenyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0010355 +name: homogentisate farnesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010356 +name: homogentisate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010357 +name: homogentisate solanesyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822] +is_a: GO:0010354 ! homogentisate prenyltransferase activity + +[Term] +id: GO:0010358 +name: leaf shaping +namespace: biological_process +def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] +synonym: "leaf structural organization" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0010359 +name: regulation of anion channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1903959 ! regulation of anion transmembrane transport + +[Term] +id: GO:0010360 +name: negative regulation of anion channel activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] +is_a: GO:0010359 ! regulation of anion channel activity +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1903960 ! negative regulation of anion transmembrane transport + +[Term] +id: GO:0010361 +name: regulation of anion channel activity by blue light +namespace: biological_process +def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] +synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010359 ! regulation of anion channel activity + +[Term] +id: GO:0010362 +name: negative regulation of anion channel activity by blue light +namespace: biological_process +def: "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] +synonym: "inhibition by blue light of anion channel activity" NARROW [] +synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010360 ! negative regulation of anion channel activity +is_a: GO:0010361 ! regulation of anion channel activity by blue light + +[Term] +id: GO:0010363 +name: regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] +comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. +synonym: "regulation of HR" EXACT [] +synonym: "regulation of HR-PCD" EXACT [] +synonym: "regulation of plant hypersensitive response" EXACT [] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0010364 +name: regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +relationship: regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010365 +name: positive regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010366 +name: negative regulation of ethylene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] +is_a: GO:0010364 ! regulation of ethylene biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process + +[Term] +id: GO:0010367 +name: extracellular isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] +is_a: GO:0043033 ! isoamylase complex +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0010368 +name: chloroplast isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] +is_a: GO:0043033 ! isoamylase complex +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0010369 +name: chromocenter +namespace: cellular_component +def: "A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0010370 +name: perinucleolar chromocenter +namespace: cellular_component +def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] +is_a: GO:0010369 ! chromocenter + +[Term] +id: GO:0010371 +name: regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010372 +name: positive regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW [] +is_a: GO:0010371 ! regulation of gibberellin biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010373 +name: negative regulation of gibberellin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] +synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] +is_a: GO:0010371 ! regulation of gibberellin biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process + +[Term] +id: GO:0010374 +name: stomatal complex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0090558 ! plant epidermis development + +[Term] +id: GO:0010375 +name: stomatal complex patterning +namespace: biological_process +def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0010376 +name: stomatal complex formation +namespace: biological_process +def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0010103 ! stomatal complex morphogenesis + +[Term] +id: GO:0010377 +name: guard cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] +synonym: "stomatal cell fate commitment" RELATED [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010052 ! guard cell differentiation + +[Term] +id: GO:0010378 +name: temperature compensation of the circadian clock +namespace: biological_process +def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] +synonym: "regulation of the circadian clock by temperature" RELATED [] +is_a: GO:0009266 ! response to temperature stimulus +is_a: GO:0042752 ! regulation of circadian rhythm + +[Term] +id: GO:0010379 +name: phaseic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271] +xref: MetaCyc:PWY-5271 +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0043289 ! apocarotenoid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0010380 +name: regulation of chlorophyll biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] +is_a: GO:0090056 ! regulation of chlorophyll metabolic process +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +relationship: regulates GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:0010381 +name: peroxisome-chloroplast membrane tethering +namespace: biological_process +def: "The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:17215364] +synonym: "attachment of peroxisome to chloroplast" EXACT [] +is_a: GO:0140056 ! organelle localization by membrane tethering + +[Term] +id: GO:0010383 +name: cell wall polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] +is_a: GO:0044036 ! cell wall macromolecule metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0010384 +name: cell wall proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] +synonym: "cell wall proteoglycan metabolism" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0044036 ! cell wall macromolecule metabolic process + +[Term] +id: GO:0010385 +name: double-stranded methylated DNA binding +namespace: molecular_function +def: "Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0010387 +name: COP9 signalosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927] +synonym: "signalosome assembly" BROAD [GOC:krc] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0010389 +name: regulation of G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] +synonym: "regulation of mitotic entry" EXACT [GOC:vw] +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition +relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0010390 +name: histone monoubiquitination +namespace: biological_process +def: "The modification of histones by addition of a single ubiquitin group." [PMID:17329563] +is_a: GO:0006513 ! protein monoubiquitination +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0010391 +name: glucomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] +synonym: "glucomannan metabolism" EXACT [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0010392 +name: galactoglucomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] +synonym: "galactoglucomannan metabolism" RELATED [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0010393 +name: galacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] +synonym: "galacturonan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0010394 +name: homogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] +synonym: "homogalacturonan metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010395 +name: rhamnogalacturonan I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] +synonym: "RGI metabolism" RELATED [] +synonym: "rhamnogalacturonan I metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0052546 ! cell wall pectin metabolic process + +[Term] +id: GO:0010396 +name: rhamnogalacturonan II metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] +synonym: "rhamnogalacturonan II metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010397 +name: apiogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] +synonym: "apiogalacturonan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0010398 +name: xylogalacturonan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] +synonym: "xylogalacturonan metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0010399 +name: rhamnogalacturonan I backbone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] +synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] +is_a: GO:0010395 ! rhamnogalacturonan I metabolic process + +[Term] +id: GO:0010400 +name: rhamnogalacturonan I side chain metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] +synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] +is_a: GO:0010395 ! rhamnogalacturonan I metabolic process + +[Term] +id: GO:0010401 +name: pectic galactan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic galactan metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process + +[Term] +id: GO:0010402 +name: pectic arabinan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic arabinan metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process + +[Term] +id: GO:0010403 +name: pectic arabinogalactan I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] +synonym: "pectic arabinogalactan I metabolism" EXACT [] +is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process + +[Term] +id: GO:0010404 +name: cell wall hydroxyproline-rich glycoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] +synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] +is_a: GO:0010384 ! cell wall proteoglycan metabolic process + +[Term] +id: GO:0010405 +name: arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] +synonym: "arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process + +[Term] +id: GO:0010406 +name: classical arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] +synonym: "classical-arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010407 +name: non-classical arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] +synonym: "non-classical arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010408 +name: fasciclin-like arabinogalactan protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] +synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] +is_a: GO:0010405 ! arabinogalactan protein metabolic process + +[Term] +id: GO:0010409 +name: extensin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] +synonym: "extensin metabolism" EXACT [] +is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process + +[Term] +id: GO:0010410 +name: hemicellulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] +synonym: "hemicellulose metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process + +[Term] +id: GO:0010411 +name: xyloglucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] +synonym: "xyloglucan metabolism" EXACT [GOC:obol] +is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0010410 ! hemicellulose metabolic process + +[Term] +id: GO:0010412 +name: mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] +synonym: "mannan metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process + +[Term] +id: GO:0010413 +name: glucuronoxylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] +synonym: "glucuronoxylan metabolism" EXACT [] +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0010414 +name: glucuronoarabinoxylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] +synonym: "glucuronoarabinoxylan metabolism" EXACT [] +is_a: GO:0010413 ! glucuronoxylan metabolic process +is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process + +[Term] +id: GO:0010415 +name: unsubstituted mannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] +synonym: "unsubstituted mannan metabolism" EXACT [] +is_a: GO:0010412 ! mannan metabolic process + +[Term] +id: GO:0010416 +name: arabinoxylan-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] +synonym: "arabinoxylan metabolic process" RELATED [] +synonym: "arabinoxylan metabolism" RELATED [] +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0010417 +name: glucuronoxylan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] +synonym: "glucuronoxylan anabolism" EXACT [] +synonym: "glucuronoxylan biosynthesis" EXACT [] +synonym: "glucuronoxylan formation" EXACT [] +synonym: "glucuronoxylan synthesis" EXACT [] +is_a: GO:0010413 ! glucuronoxylan metabolic process +is_a: GO:0045492 ! xylan biosynthetic process + +[Term] +id: GO:0010418 +name: rhamnogalacturonan II backbone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] +synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] +is_a: GO:0010394 ! homogalacturonan metabolic process +is_a: GO:0010396 ! rhamnogalacturonan II metabolic process + +[Term] +id: GO:0010419 +name: rhamnogalacturonan II side chain metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] +synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] +is_a: GO:0010396 ! rhamnogalacturonan II metabolic process + +[Term] +id: GO:0010420 +name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity +namespace: molecular_function +alt_id: GO:1990886 +def: "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+." [PMID:10419476, PMID:9628017, RHEA:44452] +synonym: "polyprenyldihydroxybenzoate methyltransferase activity" RELATED [] +xref: EC:2.1.1.114 +xref: MetaCyc:RXN-9281 +xref: RHEA:44452 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0010421 +name: hydrogen peroxide-mediated programmed cell death +namespace: biological_process +def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:16036580] +synonym: "programmed cell death in response to hydrogen peroxide" EXACT [] +is_a: GO:0036474 ! cell death in response to hydrogen peroxide +is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species + +[Term] +id: GO:0010422 +name: regulation of brassinosteroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process +relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process + +[Term] +id: GO:0010423 +name: negative regulation of brassinosteroid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] +is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process +is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process +relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process + +[Term] +id: GO:0010424 +name: DNA methylation on cytosine within a CG sequence +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] +synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010425 +name: DNA methylation on cytosine within a CNG sequence +namespace: biological_process +def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] +synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010426 +name: DNA methylation on cytosine within a CHH sequence +namespace: biological_process +def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600] +synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah] +synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] +synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0010427 +name: abscisic acid binding +namespace: molecular_function +def: "Binding to abscisic acid, a plant hormone that regulates aspects of plant growth." [PMID:17347412] +synonym: "ABA binding" RELATED [] +synonym: "abscisate binding" RELATED [] +is_a: GO:0019840 ! isoprenoid binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0042562 ! hormone binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0010428 +name: methyl-CpNpG binding +namespace: molecular_function +def: "Binding to a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0010429 +name: methyl-CpNpN binding +namespace: molecular_function +def: "Binding to a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0010430 +name: fatty acid omega-oxidation +namespace: biological_process +def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574] +xref: MetaCyc:PWY-2724 +is_a: GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0010431 +name: seed maturation +namespace: biological_process +def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048609 ! multicellular organismal reproductive process +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0010432 +name: bract development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:0048827 ! phyllome development + +[Term] +id: GO:0010433 +name: bract morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:1905392 ! plant organ morphogenesis +relationship: part_of GO:0010432 ! bract development + +[Term] +id: GO:0010434 +name: bract formation +namespace: biological_process +def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] +is_a: GO:1905393 ! plant organ formation +relationship: part_of GO:0010433 ! bract morphogenesis + +[Term] +id: GO:0010435 +name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437] +synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695] +synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT [] +synonym: "OPC-8:0 CoA ligase activity" EXACT [] +xref: EC:6.2.1.- +xref: MetaCyc:RXN-10695 +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0010436 +name: carotenoid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] +synonym: "carotenoid-cleaving dioxygenase" RELATED [] +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0010437 +name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] +is_a: GO:0010436 ! carotenoid dioxygenase activity + +[Term] +id: GO:0010438 +name: cellular response to sulfur starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0010439 +name: regulation of glucosinolate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0019761 ! glucosinolate biosynthetic process + +[Term] +id: GO:0010440 +name: stomatal lineage progression +namespace: biological_process +def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0010374 ! stomatal complex development + +[Term] +id: GO:0010441 +name: guard cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0010052 ! guard cell differentiation + +[Term] +id: GO:0010442 +name: guard cell morphogenesis +namespace: biological_process +def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] +synonym: "guard cell morphogenesis during differentiation" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0010441 ! guard cell development + +[Term] +id: GO:0010443 +name: meristemoid mother cell division +namespace: biological_process +def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] +synonym: "meristemoid division" RELATED [] +is_a: GO:0000911 ! cytokinesis by cell plate formation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010444 +name: guard mother cell differentiation +namespace: biological_process +def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] +is_a: GO:0090627 ! plant epidermal cell differentiation +relationship: part_of GO:0010440 ! stomatal lineage progression + +[Term] +id: GO:0010445 +name: nuclear dicing body +namespace: cellular_component +def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] +synonym: "D body" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0010446 +name: response to alkaline pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, Wikipedia:PH] +synonym: "response to alkalinity" BROAD [] +synonym: "response to basic pH" EXACT [] +is_a: GO:0009268 ! response to pH + +[Term] +id: GO:0010447 +name: response to acidic pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, Wikipedia:PH] +comment: This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'. +synonym: "response to acidity" BROAD [] +is_a: GO:0009268 ! response to pH + +[Term] +id: GO:0010448 +name: vegetative meristem growth +namespace: biological_process +def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] +is_a: GO:0035266 ! meristem growth +is_a: GO:0080186 ! developmental vegetative growth +relationship: part_of GO:0048367 ! shoot system development + +[Term] +id: GO:0010449 +name: root meristem growth +namespace: biological_process +def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010450 +name: inflorescence meristem growth +namespace: biological_process +def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0010229 ! inflorescence development + +[Term] +id: GO:0010451 +name: floral meristem growth +namespace: biological_process +def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0035266 ! meristem growth +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010452 +name: histone H3-K36 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone." [GOC:pr, GOC:tb] +synonym: "histone H3 K36 methylation" EXACT [GOC:tb] +synonym: "histone H3K36me" EXACT [GOC:tb] +synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0010453 +name: regulation of cell fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010454 +name: negative regulation of cell fate commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010455 +name: positive regulation of cell fate commitment +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0045165 ! cell fate commitment + +[Term] +id: GO:0010456 +name: cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] +is_a: GO:0061351 ! neural precursor cell proliferation + +[Term] +id: GO:0010457 +name: centriole-centriole cohesion +namespace: biological_process +def: "The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007098 ! centrosome cycle + +[Term] +id: GO:0010458 +name: exit from mitosis +namespace: biological_process +def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] +synonym: "exit from mitotic division" EXACT [] +synonym: "mitotic exit" EXACT [] +is_a: GO:0044772 ! mitotic cell cycle phase transition +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0010459 +name: negative regulation of heart rate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0045822 ! negative regulation of heart contraction + +[Term] +id: GO:0010460 +name: positive regulation of heart rate +namespace: biological_process +def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0045823 ! positive regulation of heart contraction + +[Term] +id: GO:0010461 +name: light-activated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] +is_a: GO:0005216 ! ion channel activity + +[Term] +id: GO:0010462 +name: regulation of light-activated voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity + +[Term] +id: GO:0010463 +name: mesenchymal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0010464 +name: regulation of mesenchymal cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0010465 +name: nerve growth factor receptor activity +namespace: molecular_function +def: "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] +synonym: "beta-nerve growth factor receptor activity" EXACT [PR:000011194] +synonym: "NGF receptor activity" EXACT [PR:000011194] +is_a: GO:0005030 ! neurotrophin receptor activity + +[Term] +id: GO:0010466 +name: negative regulation of peptidase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:0010467 +name: gene expression +namespace: biological_process +def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] +subset: goslim_flybase_ribbon +xref: Wikipedia:Gene_expression +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010468 +name: regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] +comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. +synonym: "gene regulation" RELATED [GOC:cjm] +synonym: "regulation of gene product expression" RELATED [] +synonym: "regulation of protein expression" NARROW [] +xref: Wikipedia:Regulation_of_gene_expression +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010469 +name: regulation of signaling receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] +synonym: "regulation of receptor activity" BROAD [] +synonym: "regulation of signalling receptor activity" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0010470 +name: regulation of gastrulation +namespace: biological_process +def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0045995 ! regulation of embryonic development +relationship: regulates GO:0007369 ! gastrulation + +[Term] +id: GO:0010471 +name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate." [MetaCyc:RXN4FS-12, PMID:17485667] +synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] +synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12] +xref: MetaCyc:RXN4FS-12 +is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity + +[Term] +id: GO:0010472 +name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose." [MetaCyc:RXN4FS-13, PMID:17485667] +synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] +synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13] +xref: MetaCyc:RXN4FS-13 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0010473 +name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0010474 +name: glucose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] +synonym: "GDP:glucose-1-phosphate guanyltransferase activity" EXACT [] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0010475 +name: galactose-1-phosphate guanylyltransferase (GDP) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] +synonym: "GDP:galactose-1-phosphate guanyltransferase activity" EXACT [] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0010476 +name: gibberellin mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] +synonym: "gibberellin-mediated signalling" EXACT [GOC:mah] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071370 ! cellular response to gibberellin stimulus + +[Term] +id: GO:0010477 +name: response to sulfur dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0010478 +name: chlororespiration +namespace: biological_process +def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] +is_a: GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0010479 +name: stele development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0010480 +name: microsporocyte differentiation +namespace: biological_process +def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248, PMID:16751349] +synonym: "pollen mother cell differentiation" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048533 ! sporocyte differentiation +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0010481 +name: epidermal cell division +namespace: biological_process +def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] +synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0010482 +name: regulation of epidermal cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] +synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0010481 ! epidermal cell division + +[Term] +id: GO:0010483 +name: pollen tube reception +namespace: biological_process +def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0010484 +name: H3 histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0010485 +name: H4 histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0010486 +name: manganese:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] +synonym: "manganese:hydrogen antiporter activity" EXACT [] +is_a: GO:0005384 ! manganese ion transmembrane transporter activity +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0010487 +name: thermospermine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575] +xref: EC:2.5.1.79 +xref: MetaCyc:RXN-11190 +xref: RHEA:30515 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0010488 +name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0010489 +name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0010490 +name: UDP-4-keto-rhamnose-4-keto-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0010491 +name: UTP:arabinose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0010492 +name: maintenance of shoot apical meristem identity +namespace: biological_process +def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] +is_a: GO:0010074 ! maintenance of meristem identity + +[Term] +id: GO:0010493 +name: Lewis a epitope biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] +synonym: "LE A biosynthetic process" RELATED [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0010494 +name: cytoplasmic stress granule +namespace: cellular_component +def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] +synonym: "cytoplasmic mRNP granule" EXACT [] +synonym: "stress granule" EXACT [] +xref: Wikipedia:Stress_granule +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0010495 +name: long-distance posttranscriptional gene silencing +namespace: biological_process +def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] +synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0010496 +name: intercellular transport +namespace: biological_process +alt_id: GO:1902585 +def: "The movement of substances between cells." [GOC:dhl] +synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] +synonym: "single-organism intercellular transport" RELATED [] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0010497 +name: plasmodesmata-mediated intercellular transport +namespace: biological_process +alt_id: GO:1902587 +def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] +synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] +synonym: "plasmodesma-mediated intercellular transport" EXACT [] +synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] +synonym: "single organism plasmodesmata-mediated intercellular transport" RELATED [GOC:TermGenie] +synonym: "single-organism plasmodesmata-mediated intercellular transport" RELATED [] +is_a: GO:0010496 ! intercellular transport + +[Term] +id: GO:0010498 +name: proteasomal protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] +synonym: "proteasome-mediated protein catabolic process" EXACT [] +synonym: "proteasome-mediated protein catabolism" EXACT [] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0010499 +name: proteasomal ubiquitin-independent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] +is_a: GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0010500 +name: transmitting tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] +is_a: GO:0048467 ! gynoecium development + +[Term] +id: GO:0010501 +name: RNA secondary structure unwinding +namespace: biological_process +def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] +synonym: "RNA duplex unwinding" EXACT [GOC:ecd] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0010503 +name: obsolete negative regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. +is_obsolete: true + +[Term] +id: GO:0010504 +name: obsolete regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. +is_obsolete: true + +[Term] +id: GO:0010505 +name: obsolete positive regulation of cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. +is_obsolete: true + +[Term] +id: GO:0010506 +name: regulation of autophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010507 +name: negative regulation of autophagy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0031330 ! negative regulation of cellular catabolic process +relationship: negatively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010508 +name: positive regulation of autophagy +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0031331 ! positive regulation of cellular catabolic process +relationship: positively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0010509 +name: polyamine homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0010510 +name: regulation of acetyl-CoA biosynthetic process from pyruvate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] +is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process +relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate + +[Term] +id: GO:0010511 +name: regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010512 +name: negative regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010513 +name: positive regulation of phosphatidylinositol biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0010514 +name: induction of conjugation with cellular fusion +namespace: biological_process +def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0010515 +name: negative regulation of induction of conjugation with cellular fusion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion +relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion + +[Term] +id: GO:0010516 +name: negative regulation of cellular response to nitrogen starvation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation + +[Term] +id: GO:0010517 +name: regulation of phospholipase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0010518 +name: positive regulation of phospholipase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010517 ! regulation of phospholipase activity +is_a: GO:0060193 ! positive regulation of lipase activity + +[Term] +id: GO:0010519 +name: negative regulation of phospholipase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010517 ! regulation of phospholipase activity +is_a: GO:0060192 ! negative regulation of lipase activity + +[Term] +id: GO:0010520 +name: regulation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010521 +name: telomerase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of telomerase." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0010522 +name: regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0051924 ! regulation of calcium ion transport +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0060402 ! calcium ion transport into cytosol + +[Term] +id: GO:0010523 +name: negative regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051926 ! negative regulation of calcium ion transport +relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol + +[Term] +id: GO:0010524 +name: positive regulation of calcium ion transport into cytosol +namespace: biological_process +def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051928 ! positive regulation of calcium ion transport +relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol + +[Term] +id: GO:0010525 +name: regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +relationship: regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010526 +name: negative regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010525 ! regulation of transposition, RNA-mediated +is_a: GO:0010529 ! negative regulation of transposition +relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010527 +name: positive regulation of transposition, RNA-mediated +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] +is_a: GO:0010525 ! regulation of transposition, RNA-mediated +is_a: GO:0010530 ! positive regulation of transposition +relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0010528 +name: regulation of transposition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0032196 ! transposition + +[Term] +id: GO:0010529 +name: negative regulation of transposition +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0032196 ! transposition + +[Term] +id: GO:0010530 +name: positive regulation of transposition +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] +is_a: GO:0010528 ! regulation of transposition +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0032196 ! transposition + +[Term] +id: GO:0010533 +name: regulation of activation of Janus kinase activity +namespace: biological_process +alt_id: GO:0010532 +alt_id: GO:0010534 +def: "Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582] +synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of activation of JAK1 kinase activity" NARROW [] +synonym: "regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of activation of JAK2 kinase activity" NARROW [] +synonym: "regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] +is_a: GO:0045859 ! regulation of protein kinase activity +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: regulates GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0010536 +name: positive regulation of activation of Janus kinase activity +namespace: biological_process +alt_id: GO:0010535 +alt_id: GO:0010537 +def: "Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] +synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of activation of JAK1 kinase activity" NARROW [] +synonym: "positive regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of activation of JAK2 kinase activity" NARROW [] +synonym: "positive regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010533 ! regulation of activation of Janus kinase activity +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:0010538 +name: obsolete Hsp27 protein regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. +synonym: "Hsp27 protein regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051008 +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0010539 +name: obsolete Hsp27 protein inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. +synonym: "Hsp27 protein inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051008 +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0010540 +name: basipetal auxin transport +namespace: biological_process +def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] +is_a: GO:0009926 ! auxin polar transport + +[Term] +id: GO:0010541 +name: acropetal auxin transport +namespace: biological_process +def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] +is_a: GO:0009926 ! auxin polar transport + +[Term] +id: GO:0010542 +name: nitrate efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] +is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0010543 +name: regulation of platelet activation +namespace: biological_process +def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010544 +name: negative regulation of platelet activation +namespace: biological_process +def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010543 ! regulation of platelet activation +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:0050866 ! negative regulation of cell activation +relationship: negatively_regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010545 +name: obsolete Hsp90 protein regulator activity +namespace: molecular_function +def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. +synonym: "Hsp90 protein regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051879 +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0010546 +name: obsolete Hsp90 protein inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. +synonym: "Hsp90 protein inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051879 +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0010547 +name: thylakoid membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733] +synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010027 ! thylakoid membrane organization +is_a: GO:0030397 ! membrane disassembly + +[Term] +id: GO:0010548 +name: regulation of thylakoid membrane disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733] +synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010549 ! regulation of membrane disassembly +relationship: regulates GO:0010547 ! thylakoid membrane disassembly + +[Term] +id: GO:0010549 +name: regulation of membrane disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0030397 ! membrane disassembly + +[Term] +id: GO:0010550 +name: regulation of PSII associated light-harvesting complex II catabolic process +namespace: biological_process +def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb] +synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733] +synonym: "regulation of LHCII degradation" EXACT [PMID:17416733] +is_a: GO:1903362 ! regulation of cellular protein catabolic process +relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process + +[Term] +id: GO:0010555 +name: response to mannitol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [PMID:17999646] +synonym: "response to mannitol stimulus" EXACT [GOC:dos] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0010556 +name: regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010557 +name: positive regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010558 +name: negative regulation of macromolecule biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0010559 +name: regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +is_a: GO:1903018 ! regulation of glycoprotein metabolic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010560 +name: positive regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process +relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010561 +name: negative regulation of glycoprotein biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0010562 +name: positive regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: positively_regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0010563 +name: negative regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0010564 +name: regulation of cell cycle process +namespace: biological_process +def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +relationship: regulates GO:0022402 ! cell cycle process + +[Term] +id: GO:0010565 +name: regulation of cellular ketone metabolic process +namespace: biological_process +def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0010566 +name: regulation of ketone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0042181 ! ketone biosynthetic process + +[Term] +id: GO:0010567 +name: regulation of ketone catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0042182 ! ketone catabolic process + +[Term] +id: GO:0010568 +name: regulation of budding cell apical bud growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630] +is_a: GO:0040008 ! regulation of growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007118 ! budding cell apical bud growth + +[Term] +id: GO:0010569 +name: regulation of double-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:2000779 ! regulation of double-strand break repair +relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0010570 +name: regulation of filamentous growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0040008 ! regulation of growth +relationship: regulates GO:0030447 ! filamentous growth + +[Term] +id: GO:0010571 +name: positive regulation of nuclear cell cycle DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] +synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of DNA replication involved in S phase" EXACT [] +synonym: "positive regulation of DNA replication involved in S-phase" EXACT [] +is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication +relationship: positively_regulates GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:0010572 +name: positive regulation of platelet activation +namespace: biological_process +def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010543 ! regulation of platelet activation +is_a: GO:0050867 ! positive regulation of cell activation +relationship: positively_regulates GO:0030168 ! platelet activation + +[Term] +id: GO:0010573 +name: vascular endothelial growth factor production +namespace: biological_process +def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl] +synonym: "VEGF production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0010574 +name: regulation of vascular endothelial growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0010573 ! vascular endothelial growth factor production + +[Term] +id: GO:0010575 +name: positive regulation of vascular endothelial growth factor production +namespace: biological_process +def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0010574 ! regulation of vascular endothelial growth factor production +relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production + +[Term] +id: GO:0010578 +name: regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] +synonym: "regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] +synonym: "regulation of adenylate cyclase activity involved in G-protein signaling pathway" EXACT [GOC:signaling] +synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah] +is_a: GO:0045761 ! regulation of adenylate cyclase activity +relationship: part_of GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0010581 +name: regulation of starch biosynthetic process +namespace: biological_process +def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:2000904 ! regulation of starch metabolic process +relationship: regulates GO:0019252 ! starch biosynthetic process + +[Term] +id: GO:0010582 +name: floral meristem determinacy +namespace: biological_process +def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010022 ! meristem determinacy +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0010583 +name: response to cyclopentenone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0010584 +name: pollen exine formation +namespace: biological_process +def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl] +is_a: GO:0010208 ! pollen wall assembly + +[Term] +id: GO:0010585 +name: glutamine secretion +namespace: biological_process +def: "The controlled release of glutamine by a cell." [PMID:15208395] +is_a: GO:0006868 ! glutamine transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0010586 +name: miRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] +subset: goslim_drosophila +synonym: "microRNA metabolic process" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0010587 +name: miRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] +synonym: "microRNA catabolic process" EXACT [] +is_a: GO:0010586 ! miRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0010588 +name: cotyledon vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439] +is_a: GO:0010051 ! xylem and phloem pattern formation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0048826 ! cotyledon morphogenesis + +[Term] +id: GO:0010589 +name: leaf proximal/distal pattern formation +namespace: biological_process +def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054] +is_a: GO:0009954 ! proximal/distal pattern formation + +[Term] +id: GO:0010590 +name: regulation of septum digestion after cytokinesis +namespace: biological_process +alt_id: GO:1902467 +alt_id: GO:2001041 +def: "Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] +synonym: "regulation of cell separation after cytokinesis" RELATED [] +synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of mitotic cytokinetic cell separation" EXACT [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:0010591 +name: regulation of lamellipodium assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902743 ! regulation of lamellipodium organization +relationship: regulates GO:0030032 ! lamellipodium assembly + +[Term] +id: GO:0010592 +name: positive regulation of lamellipodium assembly +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah] +is_a: GO:0010591 ! regulation of lamellipodium assembly +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902745 ! positive regulation of lamellipodium organization +relationship: positively_regulates GO:0030032 ! lamellipodium assembly + +[Term] +id: GO:0010593 +name: negative regulation of lamellipodium assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] +synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah] +is_a: GO:0010591 ! regulation of lamellipodium assembly +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902744 ! negative regulation of lamellipodium organization +relationship: negatively_regulates GO:0030032 ! lamellipodium assembly + +[Term] +id: GO:0010594 +name: regulation of endothelial cell migration +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010632 ! regulation of epithelial cell migration +relationship: regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010595 +name: positive regulation of endothelial cell migration +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010594 ! regulation of endothelial cell migration +is_a: GO:0010634 ! positive regulation of epithelial cell migration +relationship: positively_regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010596 +name: negative regulation of endothelial cell migration +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010594 ! regulation of endothelial cell migration +is_a: GO:0010633 ! negative regulation of epithelial cell migration +relationship: negatively_regulates GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0010597 +name: green leaf volatile biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881] +is_a: GO:0019372 ! lipoxygenase pathway + +[Term] +id: GO:0010598 +name: NAD(P)H dehydrogenase complex (plastoquinone) +namespace: cellular_component +def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0010599 +name: primary lsiRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary lsiRNA transcript into a mature lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861] +synonym: "production of lsiRNA involved in RNA interference" RELATED [] +synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah] +is_a: GO:0070918 ! primary sncRNA processing +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0010600 +name: regulation of auxin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0090354 ! regulation of auxin metabolic process +relationship: regulates GO:0009851 ! auxin biosynthetic process + +[Term] +id: GO:0010601 +name: positive regulation of auxin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] +is_a: GO:0010600 ! regulation of auxin biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0090355 ! positive regulation of auxin metabolic process +relationship: positively_regulates GO:0009851 ! auxin biosynthetic process + +[Term] +id: GO:0010602 +name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process +namespace: biological_process +def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process + +[Term] +id: GO:0010603 +name: regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0033962 ! P-body assembly + +[Term] +id: GO:0010604 +name: positive regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: positively_regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010605 +name: negative regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0010606 +name: positive regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0033962 ! P-body assembly + +[Term] +id: GO:0010607 +name: negative regulation of cytoplasmic mRNA processing body assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0033962 ! P-body assembly + +[Term] +id: GO:0010608 +name: posttranscriptional regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0010609 +name: mRNA localization resulting in posttranscriptional regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb] +synonym: "mRNA localisation resulting in posttranscriptional regulation of gene expression" EXACT [] +synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah] +synonym: "posttranscriptional regulation of gene expression by mRNA localization" EXACT [] +is_a: GO:0008298 ! intracellular mRNA localization +is_a: GO:0010608 ! posttranscriptional regulation of gene expression + +[Term] +id: GO:0010610 +name: regulation of mRNA stability involved in response to stress +namespace: biological_process +def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb] +is_a: GO:0043488 ! regulation of mRNA stability +relationship: part_of GO:0033554 ! cellular response to stress + +[Term] +id: GO:0010611 +name: regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0003300 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010612 +name: regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010613 +name: positive regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy +is_a: GO:0014742 ! positive regulation of muscle hypertrophy +relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010614 +name: negative regulation of cardiac muscle hypertrophy +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy +is_a: GO:0014741 ! negative regulation of muscle hypertrophy +relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy + +[Term] +id: GO:0010615 +name: positive regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010616 +name: negative regulation of cardiac muscle adaptation +namespace: biological_process +def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0010617 +name: circadian regulation of calcium ion oscillation +namespace: biological_process +def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000] +synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED [] +synonym: "circadian regulation of Ca2+ oscillation" RELATED [] +synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb] +synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED [] +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0010618 +name: aerenchyma formation +namespace: biological_process +def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0010619 +name: adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:signaling, GOC:tb] +synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" EXACT [GOC:dph, GOC:tb] +synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway" EXACT [GOC:signaling] +synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" EXACT [GOC:mah] +synonym: "glucose-sensing PKA pathway" EXACT [] +is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway +relationship: part_of GO:0010255 ! glucose mediated signaling pathway + +[Term] +id: GO:0010620 +name: negative regulation of transcription by transcription factor catabolism +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:bf, GOC:dph, GOC:tb] +is_a: GO:0036369 ! transcription factor catabolic process +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0010621 +name: negative regulation of transcription by transcription factor localization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb] +synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0010622 +name: specification of ovule identity +namespace: biological_process +def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0003002 ! regionalization +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0048482 ! plant ovule morphogenesis + +[Term] +id: GO:0010623 +name: programmed cell death involved in cell development +namespace: biological_process +def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. +synonym: "developmental programmed cell death" BROAD [] +synonym: "programmed cell death involved in development" BROAD [] +is_a: GO:0012501 ! programmed cell death +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0010624 +name: regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010625 +name: positive regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010624 ! regulation of Schwann cell proliferation +is_a: GO:0060252 ! positive regulation of glial cell proliferation +relationship: positively_regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010626 +name: negative regulation of Schwann cell proliferation +namespace: biological_process +def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0010624 ! regulation of Schwann cell proliferation +is_a: GO:0060253 ! negative regulation of glial cell proliferation +relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation + +[Term] +id: GO:0010628 +name: positive regulation of gene expression +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +relationship: positively_regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010629 +name: negative regulation of gene expression +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] +comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. +synonym: "gene silencing" RELATED [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +relationship: negatively_regulates GO:0010467 ! gene expression + +[Term] +id: GO:0010630 +name: regulation of transcription, start site selection +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process + +[Term] +id: GO:0010631 +name: epithelial cell migration +namespace: biological_process +def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0090132 ! epithelium migration + +[Term] +id: GO:0010632 +name: regulation of epithelial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010633 +name: negative regulation of epithelial cell migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010632 ! regulation of epithelial cell migration +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010634 +name: positive regulation of epithelial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010632 ! regulation of epithelial cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0010635 +name: regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0010821 ! regulation of mitochondrion organization +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010636 +name: positive regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0010635 ! regulation of mitochondrial fusion +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010637 +name: negative regulation of mitochondrial fusion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] +is_a: GO:0010635 ! regulation of mitochondrial fusion +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0008053 ! mitochondrial fusion + +[Term] +id: GO:0010638 +name: positive regulation of organelle organization +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] +synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] +synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0010639 +name: negative regulation of organelle organization +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] +synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] +synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0010640 +name: regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010641 +name: positive regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010642 +name: negative regulation of platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0010643 +name: cell communication by chemical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0007154 ! cell communication + +[Term] +id: GO:0010644 +name: cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0007154 ! cell communication + +[Term] +id: GO:0010645 +name: regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +relationship: regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010646 +name: regulation of cell communication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010647 +name: positive regulation of cell communication +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010648 +name: negative regulation of cell communication +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0007154 ! cell communication + +[Term] +id: GO:0010649 +name: regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +relationship: regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010650 +name: positive regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0010649 ! regulation of cell communication by electrical coupling +relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010651 +name: negative regulation of cell communication by electrical coupling +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0010649 ! regulation of cell communication by electrical coupling +relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling + +[Term] +id: GO:0010652 +name: positive regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010645 ! regulation of cell communication by chemical coupling +is_a: GO:0010647 ! positive regulation of cell communication +relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010653 +name: negative regulation of cell communication by chemical coupling +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0010645 ! regulation of cell communication by chemical coupling +is_a: GO:0010648 ! negative regulation of cell communication +relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling + +[Term] +id: GO:0010654 +name: apical cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0009793 ! embryo development ending in seed dormancy + +[Term] +id: GO:0010656 +name: negative regulation of muscle cell apoptotic process +namespace: biological_process +def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "negative regulation of muscle cell apoptosis" NARROW [] +is_a: GO:0010660 ! regulation of muscle cell apoptotic process +is_a: GO:0043066 ! negative regulation of apoptotic process +relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process + +[Term] +id: GO:0010657 +name: muscle cell apoptotic process +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "muscle cell apoptosis" NARROW [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0010658 +name: striated muscle cell apoptotic process +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "striated muscle cell apoptosis" NARROW [] +is_a: GO:0010657 ! muscle cell apoptotic process + +[Term] +id: GO:0010659 +name: cardiac muscle cell apoptotic process +namespace: biological_process +def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "cardiac muscle cell apoptosis" NARROW [] +is_a: GO:0010658 ! striated muscle cell apoptotic process + +[Term] +id: GO:0010660 +name: regulation of muscle cell apoptotic process +namespace: biological_process +def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "regulation of muscle cell apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0010657 ! muscle cell apoptotic process + +[Term] +id: GO:0010661 +name: positive regulation of muscle cell apoptotic process +namespace: biological_process +def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "positive regulation of muscle cell apoptosis" NARROW [] +is_a: GO:0010660 ! regulation of muscle cell apoptotic process +is_a: GO:0043065 ! positive regulation of apoptotic process +relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process + +[Term] +id: GO:0010662 +name: regulation of striated muscle cell apoptotic process +namespace: biological_process +def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "regulation of striated muscle cell apoptosis" NARROW [] +is_a: GO:0010660 ! regulation of muscle cell apoptotic process +relationship: regulates GO:0010658 ! striated muscle cell apoptotic process + +[Term] +id: GO:0010663 +name: positive regulation of striated muscle cell apoptotic process +namespace: biological_process +def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] +is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process +is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process +relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process + +[Term] +id: GO:0010664 +name: negative regulation of striated muscle cell apoptotic process +namespace: biological_process +def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] +synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] +synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] +is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process +is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process +relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process + +[Term] +id: GO:0010665 +name: regulation of cardiac muscle cell apoptotic process +namespace: biological_process +def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] +is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process +relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process + +[Term] +id: GO:0010666 +name: positive regulation of cardiac muscle cell apoptotic process +namespace: biological_process +def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] +is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process +is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process +relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process + +[Term] +id: GO:0010667 +name: negative regulation of cardiac muscle cell apoptotic process +namespace: biological_process +def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] +synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] +synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] +is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process +is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process +relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process + +[Term] +id: GO:0010668 +name: ectodermal cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007398 ! ectoderm development + +[Term] +id: GO:0010669 +name: epithelial structure maintenance +namespace: biological_process +def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0010670 +name: obsolete positive regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] +comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. +synonym: "positive regulation of oxygen and reactive oxygen species metabolic process" EXACT [] +is_obsolete: true +consider: GO:2000376 +consider: GO:2000379 + +[Term] +id: GO:0010671 +name: obsolete negative regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] +comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. +synonym: "negative regulation of oxygen and reactive oxygen species metabolic process" EXACT [] +is_obsolete: true +consider: GO:2000375 +consider: GO:2000378 + +[Term] +id: GO:0010672 +name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +namespace: biological_process +alt_id: GO:1900401 +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753] +synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW [] +synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle + +[Term] +id: GO:0010673 +name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +namespace: biological_process +alt_id: GO:1900476 +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] +synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [] +synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] +synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle + +[Term] +id: GO:0010674 +name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +namespace: biological_process +alt_id: GO:1900475 +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] +synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] +synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [] +synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle +is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle + +[Term] +id: GO:0010675 +name: regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010676 +name: positive regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010677 +name: negative regulation of cellular carbohydrate metabolic process +namespace: biological_process +def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0010678 +name: negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated +namespace: biological_process +def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb] +synonym: "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] +synonym: "negative regulation of cellular carbohydrate metabolic process by repression of transcription" EXACT [GOC:bf, GOC:vw] +synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0010679 +name: obsolete cinnamic acid biosynthetic process involved in salicylic acid metabolism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0010680 +name: obsolete cinnamic acid biosynthetic process involved in coumarin metabolism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0010681 +name: obsolete cinnamic acid biosynthetic process involved in stilbene metabolism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0010682 +name: obsolete cinnamic acid biosynthetic process involved in flavonoid metabolism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0010683 +name: tricyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] +synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0010684 +name: tricyclic triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] +synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process +is_a: GO:0016105 ! triterpenoid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0010685 +name: tetracyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] +synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0010686 +name: tetracyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] +synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] +is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process +is_a: GO:0016104 ! triterpenoid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0010688 +name: negative regulation of ribosomal protein gene transcription by RNA polymerase II +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] +synonym: "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II + +[Term] +id: GO:0010689 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0010690 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0010691 +name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II +is_a: GO:0031669 ! cellular response to nutrient levels + +[Term] +id: GO:0010692 +name: regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:0010693 +name: negative regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010692 ! regulation of alkaline phosphatase activity +is_a: GO:0010923 ! negative regulation of phosphatase activity + +[Term] +id: GO:0010694 +name: positive regulation of alkaline phosphatase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] +is_a: GO:0010692 ! regulation of alkaline phosphatase activity +is_a: GO:0010922 ! positive regulation of phosphatase activity + +[Term] +id: GO:0010695 +name: regulation of mitotic spindle pole body separation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0000073 ! initial mitotic spindle pole body separation + +[Term] +id: GO:0010696 +name: positive regulation of mitotic spindle pole body separation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010695 ! regulation of mitotic spindle pole body separation +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0000073 ! initial mitotic spindle pole body separation + +[Term] +id: GO:0010697 +name: negative regulation of mitotic spindle pole body separation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] +synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010695 ! regulation of mitotic spindle pole body separation +is_a: GO:0010948 ! negative regulation of cell cycle process +relationship: negatively_regulates GO:0000073 ! initial mitotic spindle pole body separation + +[Term] +id: GO:0010698 +name: acetyltransferase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:23912279] +synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0010700 +name: negative regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] +is_a: GO:0014061 ! regulation of norepinephrine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +relationship: negatively_regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0010701 +name: positive regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] +is_a: GO:0014061 ! regulation of norepinephrine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +relationship: positively_regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0010702 +name: obsolete regulation of histolysis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. +is_obsolete: true +consider: GO:0008219 +consider: GO:0012501 + +[Term] +id: GO:0010703 +name: obsolete negative regulation of histolysis +namespace: biological_process +def: "OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. +synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb] +is_obsolete: true +consider: GO:0008219 +consider: GO:0012501 + +[Term] +id: GO:0010704 +name: meiotic DNA double-strand break processing involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000706 ! meiotic DNA double-strand break processing +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010705 +name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000706 ! meiotic DNA double-strand break processing +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010706 +name: ganglioside biosynthetic process via lactosylceramide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] +synonym: "biosynthesis of lactosylceramide precursor to ganglioside" RELATED [GOC:bf, GOC:dph, GOC:tb] +synonym: "ganglioside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] +synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001574 ! ganglioside biosynthetic process + +[Term] +id: GO:0010707 +name: globoside biosynthetic process via lactosylceramide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] +synonym: "biosynthesis of lactosylceramide precursor to globoside" RELATED [GOC:bf, GOC:dph, GOC:tb] +synonym: "globoside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] +synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb] +synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001576 ! globoside biosynthetic process + +[Term] +id: GO:0010709 +name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing +namespace: biological_process +def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb] +is_a: GO:0030491 ! heteroduplex formation +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0010710 +name: regulation of collagen catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0010711 +name: negative regulation of collagen catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010710 ! regulation of collagen catabolic process +is_a: GO:0010713 ! negative regulation of collagen metabolic process +relationship: negatively_regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0010712 +name: regulation of collagen metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010713 +name: negative regulation of collagen metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: negatively_regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010714 +name: positive regulation of collagen metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: positively_regulates GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0010715 +name: regulation of extracellular matrix disassembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: regulates GO:0022617 ! extracellular matrix disassembly + +[Term] +id: GO:0010716 +name: negative regulation of extracellular matrix disassembly +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] +synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010715 ! regulation of extracellular matrix disassembly +is_a: GO:1903054 ! negative regulation of extracellular matrix organization +relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly + +[Term] +id: GO:0010717 +name: regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010718 +name: positive regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010719 +name: negative regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition + +[Term] +id: GO:0010720 +name: positive regulation of cell development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: positively_regulates GO:0048468 ! cell development + +[Term] +id: GO:0010721 +name: negative regulation of cell development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: negatively_regulates GO:0048468 ! cell development + +[Term] +id: GO:0010722 +name: regulation of ferrochelatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb] +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0010723 +name: positive regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb] +is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus + +[Term] +id: GO:0010724 +name: regulation of definitive erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232] +synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: regulates GO:0060318 ! definitive erythrocyte differentiation + +[Term] +id: GO:0010725 +name: regulation of primitive erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232] +synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: regulates GO:0060319 ! primitive erythrocyte differentiation + +[Term] +id: GO:0010726 +name: positive regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process +relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010727 +name: negative regulation of hydrogen peroxide metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process +relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process + +[Term] +id: GO:0010728 +name: regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process +relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010729 +name: positive regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process +is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process +relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010730 +name: negative regulation of hydrogen peroxide biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] +synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process +is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process +relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process + +[Term] +id: GO:0010731 +name: protein glutathionylation +namespace: biological_process +def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +synonym: "protein amino acid glutathionylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0010732 +name: regulation of protein glutathionylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0010731 ! protein glutathionylation + +[Term] +id: GO:0010733 +name: positive regulation of protein glutathionylation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf] +is_a: GO:0010732 ! regulation of protein glutathionylation +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0010731 ! protein glutathionylation + +[Term] +id: GO:0010734 +name: negative regulation of protein glutathionylation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf] +is_a: GO:0010732 ! regulation of protein glutathionylation +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0010731 ! protein glutathionylation + +[Term] +id: GO:0010735 +name: positive regulation of transcription via serum response element binding +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0010736 +name: serum response element binding +namespace: molecular_function +def: "Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0010737 +name: protein kinase A signaling +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "PKA signaling cascade" RELATED [GOC:dph, GOC:tb] +synonym: "protein kinase A signal transduction" EXACT [GOC:signaling] +synonym: "protein kinase A signaling cascade" RELATED [GOC:signaling] +synonym: "protein kinase A signalling cascade" RELATED [GOC:mah] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0010738 +name: regulation of protein kinase A signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of protein kinase A signalling cascade" RELATED [GOC:mah] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0010737 ! protein kinase A signaling + +[Term] +id: GO:0010739 +name: positive regulation of protein kinase A signaling +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of protein kinase A signalling cascade" RELATED [GOC:mah] +is_a: GO:0010738 ! regulation of protein kinase A signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0010737 ! protein kinase A signaling + +[Term] +id: GO:0010742 +name: macrophage derived foam cell differentiation +namespace: biological_process +def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0090077 ! foam cell differentiation + +[Term] +id: GO:0010743 +name: regulation of macrophage derived foam cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation + +[Term] +id: GO:0010744 +name: positive regulation of macrophage derived foam cell differentiation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation + +[Term] +id: GO:0010745 +name: negative regulation of macrophage derived foam cell differentiation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation + +[Term] +id: GO:0010746 +name: regulation of long-chain fatty acid import across plasma membrane +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of plasma membrane long-chain fatty acid transport" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell +relationship: regulates GO:0015911 ! long-chain fatty acid import across plasma membrane + +[Term] +id: GO:0010747 +name: positive regulation of long-chain fatty acid import across plasma membrane +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of plasma membrane long-chain fatty acid transport" EXACT [] +is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0140214 ! positive regulation of long-chain fatty acid import into cell +relationship: positively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane + +[Term] +id: GO:0010748 +name: negative regulation of long-chain fatty acid import across plasma membrane +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of plasma membrane long-chain fatty acid transport" EXACT [] +is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0140213 ! negative regulation of long-chain fatty acid import into cell +relationship: negatively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane + +[Term] +id: GO:0010749 +name: regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of nitric oxide-mediated signal transduction" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010750 +name: positive regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT [] +is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010751 +name: negative regulation of nitric oxide mediated signal transduction +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT [] +is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction + +[Term] +id: GO:0010752 +name: regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010753 +name: positive regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah] +is_a: GO:0010752 ! regulation of cGMP-mediated signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010754 +name: negative regulation of cGMP-mediated signaling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah] +is_a: GO:0010752 ! regulation of cGMP-mediated signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0010755 +name: regulation of plasminogen activation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0070613 ! regulation of protein processing +relationship: regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010756 +name: positive regulation of plasminogen activation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010755 ! regulation of plasminogen activation +is_a: GO:0010954 ! positive regulation of protein processing +relationship: positively_regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010757 +name: negative regulation of plasminogen activation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010755 ! regulation of plasminogen activation +is_a: GO:0010955 ! negative regulation of protein processing +relationship: negatively_regulates GO:0031639 ! plasminogen activation + +[Term] +id: GO:0010758 +name: regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:1905521 ! regulation of macrophage migration +relationship: regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010759 +name: positive regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0010758 ! regulation of macrophage chemotaxis +is_a: GO:0071622 ! regulation of granulocyte chemotaxis +is_a: GO:0071675 ! regulation of mononuclear cell migration +is_a: GO:1905523 ! positive regulation of macrophage migration +relationship: positively_regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010760 +name: negative regulation of macrophage chemotaxis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0010758 ! regulation of macrophage chemotaxis +is_a: GO:1905522 ! negative regulation of macrophage migration +relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis + +[Term] +id: GO:0010761 +name: fibroblast migration +namespace: biological_process +def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "fibroblast cell migration" EXACT [GOC:dph] +is_a: GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0010762 +name: regulation of fibroblast migration +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] +synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0010761 ! fibroblast migration + +[Term] +id: GO:0010763 +name: positive regulation of fibroblast migration +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] +is_a: GO:0010762 ! regulation of fibroblast migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0010761 ! fibroblast migration + +[Term] +id: GO:0010764 +name: negative regulation of fibroblast migration +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] +synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] +is_a: GO:0010762 ! regulation of fibroblast migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0010761 ! fibroblast migration + +[Term] +id: GO:0010765 +name: positive regulation of sodium ion transport +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0010766 +name: negative regulation of sodium ion transport +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006814 ! sodium ion transport + +[Term] +id: GO:0010767 +name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] +is_a: GO:0006974 ! cellular response to DNA damage stimulus +is_a: GO:0034644 ! cellular response to UV +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0010768 +name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage + +[Term] +id: GO:0010769 +name: regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0022604 ! regulation of cell morphogenesis +relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010770 +name: positive regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010771 +name: negative regulation of cell morphogenesis involved in differentiation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0010772 +name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000707 ! meiotic DNA recombinase assembly +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010773 +name: meiotic DNA recombinase assembly involved in meiotic gene conversion +namespace: biological_process +def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000707 ! meiotic DNA recombinase assembly +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010774 +name: meiotic strand invasion involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000708 ! meiotic strand invasion +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010775 +name: meiotic strand invasion involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb] +is_a: GO:0000708 ! meiotic strand invasion +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010776 +name: meiotic mismatch repair involved in meiotic gene conversion +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000710 ! meiotic mismatch repair +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010777 +name: meiotic mismatch repair involved in reciprocal meiotic recombination +namespace: biological_process +def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000710 ! meiotic mismatch repair +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010778 +name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination +namespace: biological_process +def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0000711 ! meiotic DNA repair synthesis +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010779 +name: meiotic DNA repair synthesis involved in meiotic gene conversion +namespace: biological_process +def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0000711 ! meiotic DNA repair synthesis +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010780 +name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +is_a: GO:0042138 ! meiotic DNA double-strand break formation +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010781 +name: meiotic DNA double-strand break formation involved in meiotic gene conversion +namespace: biological_process +def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] +is_a: GO:0042138 ! meiotic DNA double-strand break formation +relationship: part_of GO:0006311 ! meiotic gene conversion + +[Term] +id: GO:0010782 +name: proboscis morphogenesis, labial disc-derived +namespace: biological_process +def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007454 ! labial disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010783 +name: proboscis morphogenesis, eye-antennal disc-derived +namespace: biological_process +def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010784 +name: proboscis morphogenesis, clypeo-labral disc-derived +namespace: biological_process +def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048734 ! proboscis morphogenesis + +[Term] +id: GO:0010785 +name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048202 ! clathrin coating of Golgi vesicle +relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome + +[Term] +id: GO:0010786 +name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048202 ! clathrin coating of Golgi vesicle +relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome + +[Term] +id: GO:0010787 +name: COPI coating of Golgi vesicle, inter-Golgi cisterna +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048205 ! COPI coating of Golgi vesicle +relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna + +[Term] +id: GO:0010788 +name: COPI coating of Golgi vesicle, cis-Golgi to rough ER +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] +is_a: GO:0048205 ! COPI coating of Golgi vesicle +relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough endoplasmic reticulum + +[Term] +id: GO:0010789 +name: meiotic sister chromatid cohesion involved in meiosis I +namespace: biological_process +def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0010790 +name: meiotic sister chromatid cohesion involved in meiosis II +namespace: biological_process +def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb] +is_a: GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0010791 +name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb] +is_a: GO:0000729 ! DNA double-strand break processing +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:0010792 +name: DNA double-strand break processing involved in repair via single-strand annealing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb] +is_a: GO:0000729 ! DNA double-strand break processing +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0010793 +name: regulation of mRNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb] +is_a: GO:0046831 ! regulation of RNA export from nucleus +is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization +relationship: regulates GO:0006406 ! mRNA export from nucleus + +[Term] +id: GO:0010794 +name: regulation of dolichol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0019408 ! dolichol biosynthetic process + +[Term] +id: GO:0010795 +name: regulation of ubiquinone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +relationship: regulates GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0010796 +name: regulation of multivesicular body size +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0051036 ! regulation of endosome size + +[Term] +id: GO:0010797 +name: regulation of multivesicular body size involved in endosome transport +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] +is_a: GO:0010796 ! regulation of multivesicular body size +relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway + +[Term] +id: GO:0010798 +name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism +namespace: biological_process +def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb] +is_a: GO:0010796 ! regulation of multivesicular body size +relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0010799 +name: regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010800 +name: positive regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation +relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010801 +name: negative regulation of peptidyl-threonine phosphorylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation +relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0010803 +name: regulation of tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] +synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:0010804 +name: negative regulation of tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] +synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway +relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:0010807 +name: regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] +subset: goslim_synapse +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010808 +name: positive regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] +is_a: GO:0010807 ! regulation of synaptic vesicle priming +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +relationship: positively_regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010809 +name: negative regulation of synaptic vesicle priming +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511] +is_a: GO:0010807 ! regulation of synaptic vesicle priming +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis +relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming + +[Term] +id: GO:0010810 +name: regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010811 +name: positive regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010812 +name: negative regulation of cell-substrate adhesion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0010813 +name: neuropeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010814 +name: substance P catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl] +is_a: GO:0010813 ! neuropeptide catabolic process + +[Term] +id: GO:0010815 +name: bradykinin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl] +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010816 +name: calcitonin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0010817 +name: regulation of hormone levels +namespace: biological_process +def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0010818 +name: T cell chemotaxis +namespace: biological_process +def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] +synonym: "T-cell chemotaxis" EXACT [CL:0000084] +is_a: GO:0048247 ! lymphocyte chemotaxis +is_a: GO:0072678 ! T cell migration + +[Term] +id: GO:0010819 +name: regulation of T cell chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:1901623 ! regulation of lymphocyte chemotaxis +is_a: GO:2000404 ! regulation of T cell migration +relationship: regulates GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0010820 +name: positive regulation of T cell chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010819 ! regulation of T cell chemotaxis +is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis +is_a: GO:2000406 ! positive regulation of T cell migration +relationship: positively_regulates GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0010821 +name: regulation of mitochondrion organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] +synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0010822 +name: positive regulation of mitochondrion organization +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] +synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0010821 ! regulation of mitochondrion organization +relationship: positively_regulates GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0010823 +name: negative regulation of mitochondrion organization +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] +synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0010821 ! regulation of mitochondrion organization +relationship: negatively_regulates GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0010824 +name: regulation of centrosome duplication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] +is_a: GO:0046605 ! regulation of centrosome cycle +relationship: regulates GO:0051298 ! centrosome duplication + +[Term] +id: GO:0010825 +name: positive regulation of centrosome duplication +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] +is_a: GO:0010824 ! regulation of centrosome duplication +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0051298 ! centrosome duplication + +[Term] +id: GO:0010826 +name: negative regulation of centrosome duplication +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] +is_a: GO:0010824 ! regulation of centrosome duplication +is_a: GO:0046606 ! negative regulation of centrosome cycle +relationship: negatively_regulates GO:0051298 ! centrosome duplication + +[Term] +id: GO:0010827 +name: regulation of glucose transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +synonym: "regulation of glucose transport" RELATED [] +is_a: GO:0034762 ! regulation of transmembrane transport +relationship: regulates GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0010828 +name: positive regulation of glucose transmembrane transport +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of glucose transport" RELATED [] +is_a: GO:0010827 ! regulation of glucose transmembrane transport +is_a: GO:0034764 ! positive regulation of transmembrane transport +relationship: positively_regulates GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0010829 +name: negative regulation of glucose transmembrane transport +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of glucose transport" RELATED [] +is_a: GO:0010827 ! regulation of glucose transmembrane transport +is_a: GO:0034763 ! negative regulation of transmembrane transport +relationship: negatively_regulates GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0010830 +name: regulation of myotube differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +relationship: regulates GO:0014902 ! myotube differentiation + +[Term] +id: GO:0010831 +name: positive regulation of myotube differentiation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] +is_a: GO:0010830 ! regulation of myotube differentiation +is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation +relationship: positively_regulates GO:0014902 ! myotube differentiation + +[Term] +id: GO:0010832 +name: negative regulation of myotube differentiation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] +is_a: GO:0010830 ! regulation of myotube differentiation +is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation +relationship: negatively_regulates GO:0014902 ! myotube differentiation + +[Term] +id: GO:0010833 +name: telomere maintenance via telomere lengthening +namespace: biological_process +def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0010834 +name: obsolete telomere maintenance via telomere shortening +namespace: biological_process +def: "OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it represents a phenotype. +synonym: "telomere maintenance via telomere shortening" EXACT [] +is_obsolete: true +consider: GO:1903824 + +[Term] +id: GO:0010835 +name: regulation of protein ADP-ribosylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb] +synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0006471 ! protein ADP-ribosylation + +[Term] +id: GO:0010836 +name: negative regulation of protein ADP-ribosylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] +is_a: GO:0010835 ! regulation of protein ADP-ribosylation +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0006471 ! protein ADP-ribosylation + +[Term] +id: GO:0010837 +name: regulation of keratinocyte proliferation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0043616 ! keratinocyte proliferation + +[Term] +id: GO:0010838 +name: positive regulation of keratinocyte proliferation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] +is_a: GO:0010837 ! regulation of keratinocyte proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: positively_regulates GO:0043616 ! keratinocyte proliferation + +[Term] +id: GO:0010839 +name: negative regulation of keratinocyte proliferation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] +is_a: GO:0010837 ! regulation of keratinocyte proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation + +[Term] +id: GO:0010840 +name: regulation of circadian sleep/wake cycle, wakefulness +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb] +is_a: GO:0042749 ! regulation of circadian sleep/wake cycle +relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness + +[Term] +id: GO:0010841 +name: positive regulation of circadian sleep/wake cycle, wakefulness +namespace: biological_process +def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness +is_a: GO:0042753 ! positive regulation of circadian rhythm +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness + +[Term] +id: GO:0010842 +name: retina layer formation +namespace: biological_process +def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] +synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] +synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003407 ! neural retina development +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0010843 +name: obsolete promoter binding +namespace: molecular_function +def: "OBSOLETE. Binding to a regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167] +comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae. +synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb] +synonym: "promoter binding" EXACT [] +is_obsolete: true +consider: GO:0000976 +consider: GO:0001046 + +[Term] +id: GO:0010844 +name: recombination hotspot binding +namespace: molecular_function +def: "Binding to a genomic region which promotes recombination." [GOC:dph, GOC:tb] +synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0010845 +name: positive regulation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010520 ! regulation of reciprocal meiotic recombination +is_a: GO:0045836 ! positive regulation of meiotic nuclear division +is_a: GO:0045911 ! positive regulation of DNA recombination +relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0010846 +name: activation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] +synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination + +[Term] +id: GO:0010847 +name: regulation of chromatin assembly +namespace: biological_process +def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0031497 ! chromatin assembly + +[Term] +id: GO:0010848 +name: regulation of chromatin disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +relationship: regulates GO:0031498 ! chromatin disassembly + +[Term] +id: GO:0010849 +name: regulation of proton-transporting ATPase activity, rotational mechanism +namespace: biological_process +def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb] +synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0043462 ! regulation of ATP-dependent activity + +[Term] +id: GO:0010850 +name: regulation of blood pressure by chemoreceptor signaling pathway +namespace: biological_process +def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb] +synonym: "regulation of blood pressure by chemoreceptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0007165 ! signal transduction +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0010851 +name: cyclase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0010852 +name: cyclase inhibitor activity +namespace: molecular_function +def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0010851 ! cyclase regulator activity + +[Term] +id: GO:0010853 +name: cyclase activator activity +namespace: molecular_function +def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] +is_a: GO:0010851 ! cyclase regulator activity + +[Term] +id: GO:0010854 +name: adenylate cyclase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] +is_a: GO:0010852 ! cyclase inhibitor activity + +[Term] +id: GO:0010855 +name: adenylate cyclase inhibitor activity +namespace: molecular_function +def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] +is_a: GO:0010854 ! adenylate cyclase regulator activity + +[Term] +id: GO:0010856 +name: adenylate cyclase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0010851 ! cyclase regulator activity + +[Term] +id: GO:0010857 +name: calcium-dependent protein kinase activity +namespace: molecular_function +def: "Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:dph, GOC:tb] +comment: This reaction requires the presence of calcium. +xref: Reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308" +xref: Reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308" +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0010858 +name: calcium-dependent protein kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0010859 +name: calcium-dependent cysteine-type endopeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb] +is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity + +[Term] +id: GO:0010860 +name: obsolete proteasome regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb] +comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. +synonym: "proteasome regulator activity" EXACT [] +is_obsolete: true +consider: GO:0061135 +consider: GO:0061136 + +[Term] +id: GO:0010862 +name: positive regulation of pathway-restricted SMAD protein phosphorylation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation +is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation + +[Term] +id: GO:0010863 +name: positive regulation of phospholipase C activity +namespace: biological_process +def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb] +is_a: GO:0010518 ! positive regulation of phospholipase activity +is_a: GO:1900274 ! regulation of phospholipase C activity + +[Term] +id: GO:0010864 +name: positive regulation of protein histidine kinase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0032110 ! regulation of protein histidine kinase activity +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0010865 +name: stipule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048366 ! leaf development + +[Term] +id: GO:0010866 +name: regulation of triglyceride biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] +synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:0090207 ! regulation of triglyceride metabolic process +relationship: regulates GO:0019432 ! triglyceride biosynthetic process + +[Term] +id: GO:0010867 +name: positive regulation of triglyceride biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] +synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] +is_a: GO:0010866 ! regulation of triglyceride biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0090208 ! positive regulation of triglyceride metabolic process +relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process + +[Term] +id: GO:0010868 +name: negative regulation of triglyceride biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] +synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] +is_a: GO:0010866 ! regulation of triglyceride biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0090209 ! negative regulation of triglyceride metabolic process +relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process + +[Term] +id: GO:0010869 +name: obsolete regulation of receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +is_obsolete: true + +[Term] +id: GO:0010870 +name: obsolete positive regulation of receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +is_obsolete: true + +[Term] +id: GO:0010871 +name: obsolete negative regulation of receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +is_obsolete: true + +[Term] +id: GO:0010872 +name: regulation of cholesterol esterification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0034435 ! cholesterol esterification + +[Term] +id: GO:0010873 +name: positive regulation of cholesterol esterification +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010872 ! regulation of cholesterol esterification +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +relationship: positively_regulates GO:0034435 ! cholesterol esterification + +[Term] +id: GO:0010874 +name: regulation of cholesterol efflux +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: regulates GO:0033344 ! cholesterol efflux + +[Term] +id: GO:0010875 +name: positive regulation of cholesterol efflux +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010874 ! regulation of cholesterol efflux +is_a: GO:0032376 ! positive regulation of cholesterol transport +relationship: positively_regulates GO:0033344 ! cholesterol efflux + +[Term] +id: GO:0010876 +name: lipid localization +namespace: biological_process +def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "lipid localisation" EXACT [GOC:mah] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0010877 +name: lipid transport involved in lipid storage +namespace: biological_process +def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0006869 ! lipid transport +relationship: part_of GO:0019915 ! lipid storage + +[Term] +id: GO:0010878 +name: cholesterol storage +namespace: biological_process +def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb] +synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb] +is_a: GO:0019915 ! lipid storage + +[Term] +id: GO:0010879 +name: cholesterol transport involved in cholesterol storage +namespace: biological_process +def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb] +is_a: GO:0010877 ! lipid transport involved in lipid storage +is_a: GO:0030301 ! cholesterol transport +relationship: part_of GO:0010878 ! cholesterol storage + +[Term] +id: GO:0010880 +name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum + +[Term] +id: GO:0010881 +name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum +is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling + +[Term] +id: GO:0010882 +name: regulation of cardiac muscle contraction by calcium ion signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0055117 ! regulation of cardiac muscle contraction + +[Term] +id: GO:0010883 +name: regulation of lipid storage +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0019915 ! lipid storage + +[Term] +id: GO:0010884 +name: positive regulation of lipid storage +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010883 ! regulation of lipid storage +is_a: GO:1905954 ! positive regulation of lipid localization +relationship: positively_regulates GO:0019915 ! lipid storage + +[Term] +id: GO:0010885 +name: regulation of cholesterol storage +namespace: biological_process +def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010883 ! regulation of lipid storage +relationship: regulates GO:0010878 ! cholesterol storage + +[Term] +id: GO:0010886 +name: positive regulation of cholesterol storage +namespace: biological_process +def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010884 ! positive regulation of lipid storage +is_a: GO:0010885 ! regulation of cholesterol storage +relationship: positively_regulates GO:0010878 ! cholesterol storage + +[Term] +id: GO:0010887 +name: negative regulation of cholesterol storage +namespace: biological_process +def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] +is_a: GO:0010885 ! regulation of cholesterol storage +is_a: GO:0010888 ! negative regulation of lipid storage +relationship: negatively_regulates GO:0010878 ! cholesterol storage + +[Term] +id: GO:0010888 +name: negative regulation of lipid storage +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010883 ! regulation of lipid storage +is_a: GO:1905953 ! negative regulation of lipid localization +relationship: negatively_regulates GO:0019915 ! lipid storage + +[Term] +id: GO:0010889 +name: regulation of sequestering of triglyceride +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah] +synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010883 ! regulation of lipid storage +relationship: regulates GO:0030730 ! sequestering of triglyceride + +[Term] +id: GO:0010890 +name: positive regulation of sequestering of triglyceride +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah] +synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010884 ! positive regulation of lipid storage +is_a: GO:0010889 ! regulation of sequestering of triglyceride +relationship: positively_regulates GO:0030730 ! sequestering of triglyceride + +[Term] +id: GO:0010891 +name: negative regulation of sequestering of triglyceride +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah] +synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010888 ! negative regulation of lipid storage +is_a: GO:0010889 ! regulation of sequestering of triglyceride +relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride + +[Term] +id: GO:0010892 +name: positive regulation of mitochondrial translation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0070131 ! positive regulation of mitochondrial translation + +[Term] +id: GO:0010893 +name: positive regulation of steroid biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: positively_regulates GO:0006694 ! steroid biosynthetic process + +[Term] +id: GO:0010894 +name: negative regulation of steroid biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process + +[Term] +id: GO:0010895 +name: negative regulation of ergosterol biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032443 ! regulation of ergosterol biosynthetic process +is_a: GO:0106119 ! negative regulation of sterol biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process + +[Term] +id: GO:0010896 +name: regulation of triglyceride catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] +synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +is_a: GO:0090207 ! regulation of triglyceride metabolic process +relationship: regulates GO:0019433 ! triglyceride catabolic process + +[Term] +id: GO:0010897 +name: negative regulation of triglyceride catabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] +synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah] +is_a: GO:0010896 ! regulation of triglyceride catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:0090209 ! negative regulation of triglyceride metabolic process +relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process + +[Term] +id: GO:0010898 +name: positive regulation of triglyceride catabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] +synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah] +is_a: GO:0010896 ! regulation of triglyceride catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:0090208 ! positive regulation of triglyceride metabolic process +relationship: positively_regulates GO:0019433 ! triglyceride catabolic process + +[Term] +id: GO:0010899 +name: regulation of phosphatidylcholine catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] +is_a: GO:0060696 ! regulation of phospholipid catabolic process +is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process +relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process + +[Term] +id: GO:0010900 +name: negative regulation of phosphatidylcholine catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] +is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:0150174 ! negative regulation of phosphatidylcholine metabolic process +relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process + +[Term] +id: GO:0010901 +name: regulation of very-low-density lipoprotein particle remodeling +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] +synonym: "regulation of VLDL remodeling" EXACT [GOC:tb] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling + +[Term] +id: GO:0010902 +name: positive regulation of very-low-density lipoprotein particle remodeling +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] +synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb] +is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling + +[Term] +id: GO:0010903 +name: negative regulation of very-low-density lipoprotein particle remodeling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] +synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb] +is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling + +[Term] +id: GO:0010904 +name: regulation of UDP-glucose catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] +synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: regulates GO:0006258 ! UDP-glucose catabolic process + +[Term] +id: GO:0010905 +name: negative regulation of UDP-glucose catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] +synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0010904 ! regulation of UDP-glucose catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process + +[Term] +id: GO:0010906 +name: regulation of glucose metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] +synonym: "regulation of glucose metabolism" EXACT [GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0010907 +name: positive regulation of glucose metabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] +synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0010908 +name: regulation of heparan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0010909 +name: positive regulation of heparan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] +is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process +is_a: GO:1902730 ! positive regulation of proteoglycan biosynthetic process +relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0010910 +name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb] +is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process +is_a: GO:0010912 ! positive regulation of isomerase activity + +[Term] +id: GO:0010911 +name: regulation of isomerase activity +namespace: biological_process +def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0010912 +name: positive regulation of isomerase activity +namespace: biological_process +def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] +is_a: GO:0010911 ! regulation of isomerase activity +is_a: GO:0043085 ! positive regulation of catalytic activity + +[Term] +id: GO:0010913 +name: regulation of sterigmatocystin biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process + +[Term] +id: GO:0010914 +name: positive regulation of sterigmatocystin biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] +is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process + +[Term] +id: GO:0010915 +name: regulation of very-low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance + +[Term] +id: GO:0010916 +name: negative regulation of very-low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance +is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance +relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance + +[Term] +id: GO:0010917 +name: negative regulation of mitochondrial membrane potential +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] +synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph] +is_a: GO:0045837 ! negative regulation of membrane potential +is_a: GO:0051881 ! regulation of mitochondrial membrane potential + +[Term] +id: GO:0010918 +name: positive regulation of mitochondrial membrane potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] +synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph] +is_a: GO:0045838 ! positive regulation of membrane potential +is_a: GO:0051881 ! regulation of mitochondrial membrane potential + +[Term] +id: GO:0010919 +name: regulation of inositol phosphate biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process + +[Term] +id: GO:0010920 +name: negative regulation of inositol phosphate biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] +synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process + +[Term] +id: GO:0010921 +name: regulation of phosphatase activity +namespace: biological_process +def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0010922 +name: positive regulation of phosphatase activity +namespace: biological_process +def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010921 ! regulation of phosphatase activity +is_a: GO:0035306 ! positive regulation of dephosphorylation +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0010923 +name: negative regulation of phosphatase activity +namespace: biological_process +def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010921 ! regulation of phosphatase activity +is_a: GO:0035305 ! negative regulation of dephosphorylation +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0010924 +name: regulation of inositol-polyphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:0010925 +name: positive regulation of inositol-polyphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity + +[Term] +id: GO:0010926 +name: obsolete anatomical structure formation +namespace: biological_process +def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb] +comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful. +synonym: "anatomical structure formation" EXACT [] +is_obsolete: true +consider: GO:0022607 +consider: GO:0048646 + +[Term] +id: GO:0010927 +name: cellular component assembly involved in morphogenesis +namespace: biological_process +def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0032989 ! cellular component morphogenesis + +[Term] +id: GO:0010928 +name: regulation of auxin mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] +synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009734 ! auxin-activated signaling pathway + +[Term] +id: GO:0010929 +name: positive regulation of auxin mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] +synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0010928 ! regulation of auxin mediated signaling pathway +relationship: positively_regulates GO:0009734 ! auxin-activated signaling pathway + +[Term] +id: GO:0010930 +name: negative regulation of auxin mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] +synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010928 ! regulation of auxin mediated signaling pathway +relationship: negatively_regulates GO:0009734 ! auxin-activated signaling pathway + +[Term] +id: GO:0010931 +name: macrophage tolerance induction +namespace: biological_process +def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002507 ! tolerance induction + +[Term] +id: GO:0010932 +name: regulation of macrophage tolerance induction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002643 ! regulation of tolerance induction +relationship: regulates GO:0010931 ! macrophage tolerance induction + +[Term] +id: GO:0010933 +name: positive regulation of macrophage tolerance induction +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0002645 ! positive regulation of tolerance induction +is_a: GO:0010932 ! regulation of macrophage tolerance induction +relationship: positively_regulates GO:0010931 ! macrophage tolerance induction + +[Term] +id: GO:0010934 +name: macrophage cytokine production +namespace: biological_process +def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0061082 ! myeloid leukocyte cytokine production + +[Term] +id: GO:0010935 +name: regulation of macrophage cytokine production +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0010934 ! macrophage cytokine production + +[Term] +id: GO:0010936 +name: negative regulation of macrophage cytokine production +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0010935 ! regulation of macrophage cytokine production +relationship: negatively_regulates GO:0010934 ! macrophage cytokine production + +[Term] +id: GO:0010937 +name: regulation of cytoplasmic microtubule depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] +is_a: GO:0031114 ! regulation of microtubule depolymerization +relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization + +[Term] +id: GO:0010938 +name: cytoplasmic microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] +is_a: GO:0007019 ! microtubule depolymerization +is_a: GO:0031122 ! cytoplasmic microtubule organization + +[Term] +id: GO:0010939 +name: regulation of necrotic cell death +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] +is_a: GO:0010941 ! regulation of cell death +relationship: regulates GO:0070265 ! necrotic cell death + +[Term] +id: GO:0010940 +name: positive regulation of necrotic cell death +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] +is_a: GO:0010939 ! regulation of necrotic cell death +is_a: GO:0010942 ! positive regulation of cell death +relationship: positively_regulates GO:0070265 ! necrotic cell death + +[Term] +id: GO:0010941 +name: regulation of cell death +namespace: biological_process +def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0008219 ! cell death + +[Term] +id: GO:0010942 +name: positive regulation of cell death +namespace: biological_process +def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] +is_a: GO:0010941 ! regulation of cell death +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0008219 ! cell death + +[Term] +id: GO:0010943 +name: NADPH pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb] +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0010944 +name: negative regulation of transcription by competitive promoter binding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0010945 +name: CoA pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb, PMID:10922370, PMID:16185196] +synonym: "conezyme A pyrophosphatase activity" RELATED [] +xref: Reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT" +xref: Reactome:R-HSA-6810474 "NUDT19 hydrolyses acyl-CoA to 3',5'-ADP and acyl-PPANT" +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0010946 +name: regulation of meiotic joint molecule formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0000709 ! meiotic joint molecule formation + +[Term] +id: GO:0010947 +name: negative regulation of meiotic joint molecule formation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] +is_a: GO:0010946 ! regulation of meiotic joint molecule formation +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation + +[Term] +id: GO:0010948 +name: negative regulation of cell cycle process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0045786 ! negative regulation of cell cycle +relationship: negatively_regulates GO:0022402 ! cell cycle process + +[Term] +id: GO:0010949 +name: negative regulation of intestinal phytosterol absorption +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:1904730 ! negative regulation of intestinal lipid absorption +relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption + +[Term] +id: GO:0010950 +name: positive regulation of endopeptidase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:0052548 ! regulation of endopeptidase activity + +[Term] +id: GO:0010951 +name: negative regulation of endopeptidase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] +subset: goslim_chembl +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:0052548 ! regulation of endopeptidase activity + +[Term] +id: GO:0010952 +name: positive regulation of peptidase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:0010954 +name: positive regulation of protein processing +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] +synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0070613 ! regulation of protein processing +is_a: GO:1903319 ! positive regulation of protein maturation +relationship: positively_regulates GO:0016485 ! protein processing + +[Term] +id: GO:0010955 +name: negative regulation of protein processing +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] +synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0070613 ! regulation of protein processing +is_a: GO:1903318 ! negative regulation of protein maturation +relationship: negatively_regulates GO:0016485 ! protein processing + +[Term] +id: GO:0010956 +name: negative regulation of calcidiol 1-monooxygenase activity +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process + +[Term] +id: GO:0010957 +name: negative regulation of vitamin D biosynthetic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:0060556 ! regulation of vitamin D biosynthetic process +relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process + +[Term] +id: GO:0010958 +name: regulation of amino acid import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] +synonym: "regulation of amino acid import" BROAD [] +is_a: GO:1903789 ! regulation of amino acid transmembrane transport +relationship: regulates GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:0010959 +name: regulation of metal ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0030001 ! metal ion transport + +[Term] +id: GO:0010960 +name: magnesium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0010961 +name: cellular magnesium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell." [GOC:dph, GOC:tb] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0010960 ! magnesium ion homeostasis +is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis + +[Term] +id: GO:0010962 +name: regulation of glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0010964 +name: regulation of heterochromatin assembly by small RNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heterochromatin assembly by small RNA." [GOC:dph, GOC:tb] +synonym: "regulation of chromatin silencing by small RNA" RELATED [] +synonym: "regulation of RNAi-mediated heterochromatin assembly" EXACT [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0031048 ! heterochromatin assembly by small RNA + +[Term] +id: GO:0010965 +name: regulation of mitotic sister chromatid separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] +is_a: GO:1905818 ! regulation of chromosome separation +relationship: regulates GO:0051306 ! mitotic sister chromatid separation + +[Term] +id: GO:0010966 +name: regulation of phosphate transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0044070 ! regulation of anion transport +relationship: regulates GO:0006817 ! phosphate ion transport + +[Term] +id: GO:0010967 +name: regulation of polyamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0006596 ! polyamine biosynthetic process + +[Term] +id: GO:0010968 +name: regulation of microtubule nucleation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] +is_a: GO:0031113 ! regulation of microtubule polymerization +relationship: regulates GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0010969 +name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion +relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion + +[Term] +id: GO:0010970 +name: transport along microtubule +namespace: biological_process +def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] +synonym: "microtubule-based transport" BROAD [] +synonym: "movement along microtubule" EXACT [] +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport +is_a: GO:0099111 ! microtubule-based transport + +[Term] +id: GO:0010971 +name: positive regulation of G2/M transition of mitotic cell cycle +namespace: biological_process +alt_id: GO:0031662 +def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] +synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle" RELATED [] +synonym: "positive regulation of mitotic entry" EXACT [GOC:mah] +is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle +is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition +is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition +relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0010972 +name: negative regulation of G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] +synonym: "negative regulation of mitotic entry" EXACT [GOC:vw] +is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle +is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition +is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition +relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle + +[Term] +id: GO:0010973 +name: positive regulation of division septum assembly +namespace: biological_process +alt_id: GO:1901912 +alt_id: GO:1902470 +def: "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] +synonym: "positive regulation of division septum formation" EXACT [] +synonym: "positive regulation of division septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic division septum assembly" EXACT [GOC:TermGenie] +is_a: GO:0032955 ! regulation of division septum assembly +is_a: GO:1901893 ! positive regulation of cell septum assembly +relationship: positively_regulates GO:0000917 ! division septum assembly + +[Term] +id: GO:0010974 +name: negative regulation of division septum assembly +namespace: biological_process +alt_id: GO:1901139 +alt_id: GO:1902469 +def: "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] +synonym: "inhibition of division septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of division septum formation" EXACT [] +is_a: GO:0032955 ! regulation of division septum assembly +is_a: GO:1901892 ! negative regulation of cell septum assembly +relationship: negatively_regulates GO:0000917 ! division septum assembly + +[Term] +id: GO:0010975 +name: regulation of neuron projection development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] +synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] +synonym: "regulation of neurite development" NARROW [GOC:mah] +synonym: "regulation of neurite formation" NARROW [GOC:mah] +synonym: "regulation of neurite growth" NARROW [GOC:mah] +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: regulates GO:0031175 ! neuron projection development + +[Term] +id: GO:0010976 +name: positive regulation of neuron projection development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] +synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] +synonym: "positive regulation of neurite development" NARROW [GOC:mah] +synonym: "positive regulation of neurite formation" NARROW [GOC:mah] +synonym: "positive regulation of neurite growth" NARROW [GOC:mah] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0031346 ! positive regulation of cell projection organization +relationship: positively_regulates GO:0031175 ! neuron projection development + +[Term] +id: GO:0010977 +name: negative regulation of neuron projection development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] +synonym: "growth cone collapse" RELATED [GOC:pr] +synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] +synonym: "negative regulation of neurite development" NARROW [GOC:mah] +synonym: "negative regulation of neurite formation" NARROW [GOC:mah] +synonym: "negative regulation of neurite growth" NARROW [GOC:mah] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0031345 ! negative regulation of cell projection organization +relationship: negatively_regulates GO:0031175 ! neuron projection development + +[Term] +id: GO:0010978 +name: obsolete gene silencing involved in chronological cell aging +namespace: biological_process +def: "OBSOLETE. Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb] +comment: This term was obsoleted because it represent an assay - how long the cell lives -, not a true biological process. +is_obsolete: true +consider: GO:0044838 +consider: GO:0090398 + +[Term] +id: GO:0010979 +name: regulation of vitamin D 24-hydroxylase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0010980 +name: positive regulation of vitamin D 24-hydroxylase activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity +is_a: GO:0032770 ! positive regulation of monooxygenase activity + +[Term] +id: GO:0010981 +name: regulation of cell wall macromolecule metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process + +[Term] +id: GO:0010982 +name: regulation of high-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance + +[Term] +id: GO:0010983 +name: positive regulation of high-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance +is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance +relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance + +[Term] +id: GO:0010984 +name: regulation of lipoprotein particle clearance +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0010985 +name: negative regulation of lipoprotein particle clearance +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0010986 +name: positive regulation of lipoprotein particle clearance +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0010987 +name: negative regulation of high-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance +is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance +relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance + +[Term] +id: GO:0010988 +name: regulation of low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance + +[Term] +id: GO:0010989 +name: negative regulation of low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance +is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance +relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance + +[Term] +id: GO:0010990 +name: regulation of SMAD protein complex assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0007183 ! SMAD protein complex assembly + +[Term] +id: GO:0010991 +name: negative regulation of SMAD protein complex assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010990 ! regulation of SMAD protein complex assembly +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly + +[Term] +id: GO:0010992 +name: ubiquitin recycling +namespace: biological_process +alt_id: GO:0010993 +def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates." [GOC:BHF, GOC:dph, GOC:PG, GOC:tb, PMID:19410548] +synonym: "regulation of ubiquitin homeostasis" NARROW [] +synonym: "ubiquitin homeostasis" RELATED [] +is_a: GO:0019725 ! cellular homeostasis + +[Term] +id: GO:0010994 +name: free ubiquitin chain polymerization +namespace: biological_process +def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051258 ! protein polymerization +relationship: part_of GO:0010992 ! ubiquitin recycling + +[Term] +id: GO:0010995 +name: free ubiquitin chain depolymerization +namespace: biological_process +def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051261 ! protein depolymerization +relationship: part_of GO:0010992 ! ubiquitin recycling + +[Term] +id: GO:0010996 +name: response to auditory stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] +synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb] +synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0010997 +name: anaphase-promoting complex binding +namespace: molecular_function +def: "Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "APC binding" EXACT [GOC:dph, GOC:tb] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0010998 +name: regulation of translational initiation by eIF2 alpha phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] +comment: Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'. +synonym: "eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] +synonym: "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0010999 +name: regulation of eIF2 alpha phosphorylation by heme +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation + +[Term] +id: GO:0011000 +name: replication fork arrest at mating type locus +namespace: biological_process +def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb] +is_a: GO:0043111 ! replication fork arrest + +[Term] +id: GO:0012501 +name: programmed cell death +namespace: biological_process +alt_id: GO:0016244 +def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] +comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. +subset: goslim_generic +synonym: "caspase-independent apoptosis" RELATED [] +synonym: "caspase-independent cell death" NARROW [] +synonym: "non-apoptotic programmed cell death" NARROW [] +synonym: "nonapoptotic programmed cell death" NARROW [] +synonym: "PCD" RELATED [] +synonym: "RCD" RELATED [] +synonym: "regulated cell death" BROAD [] +xref: Wikipedia:Programmed_cell_death +is_a: GO:0008219 ! cell death + +[Term] +id: GO:0012502 +name: induction of programmed cell death +namespace: biological_process +alt_id: GO:0012503 +def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr] +synonym: "induction of non-apoptotic programmed cell death" NARROW [] +synonym: "induction of nonapoptotic programmed cell death" NARROW [] +is_a: GO:0043068 ! positive regulation of programmed cell death + +[Term] +id: GO:0012505 +name: endomembrane system +namespace: cellular_component +def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_flybase_ribbon +subset: goslim_yeast +xref: Wikipedia:Endomembrane_system +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0012506 +name: vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] +xref: NIF_Subcellular:sao1153182838 +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0031982 ! vesicle + +[Term] +id: GO:0012507 +name: ER to Golgi transport vesicle membrane +namespace: cellular_component +alt_id: GO:0030664 +def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "COPII coated vesicle membrane" EXACT [] +synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] +synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] +synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "ER-Golgi transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030134 ! COPII-coated ER to Golgi transport vesicle + +[Term] +id: GO:0012508 +name: Golgi to ER transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] +synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] +synonym: "Golgi to ER constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] +synonym: "Golgi-ER transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030663 ! COPI-coated vesicle membrane +relationship: part_of GO:0030142 ! COPI-coated Golgi to ER transport vesicle + +[Term] +id: GO:0012509 +name: inter-Golgi transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] +synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030663 ! COPI-coated vesicle membrane +relationship: part_of GO:0030143 ! COPI-coated inter-Golgi transport vesicle + +[Term] +id: GO:0012510 +name: trans-Golgi network transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] +synonym: "TGN transport vesicle membrane" EXACT [] +synonym: "trans-Golgi network constitutive secretory pathway transport vesicle membrane" EXACT [] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030660 ! Golgi-associated vesicle membrane +is_a: GO:0030665 ! clathrin-coated vesicle membrane +relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle + +[Term] +id: GO:0012511 +name: monolayer-surrounded lipid storage body +namespace: cellular_component +alt_id: GO:0009520 +def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] +synonym: "oil body" EXACT [] +synonym: "oilbody" EXACT [] +synonym: "oleosome" EXACT [] +synonym: "spherosome" EXACT [] +xref: Wikipedia:Oil_body +is_a: GO:0005811 ! lipid droplet + +[Term] +id: GO:0014001 +name: sclerenchyma cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0014002 +name: astrocyte development +namespace: biological_process +def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] +synonym: "astrocyte cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0014003 +name: oligodendrocyte development +namespace: biological_process +def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] +synonym: "oligodendrocyte cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0014004 +name: microglia differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] +synonym: "microglial cell differentiation" EXACT [] +is_a: GO:0010001 ! glial cell differentiation +is_a: GO:0030225 ! macrophage differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0014005 +name: microglia development +namespace: biological_process +def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] +synonym: "microglial cell development" EXACT [] +is_a: GO:0021782 ! glial cell development +is_a: GO:0061515 ! myeloid cell development +relationship: part_of GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014006 +name: regulation of microglia differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "regulation of microglial cell differentiation" EXACT [] +is_a: GO:0045649 ! regulation of macrophage differentiation +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014007 +name: negative regulation of microglia differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "down regulation of microglia differentiation" EXACT [] +synonym: "down-regulation of microglia differentiation" EXACT [] +synonym: "downregulation of microglia differentiation" EXACT [] +synonym: "inhibition of microglia differentiation" NARROW [] +synonym: "negative regulation of microglial cell differentiation" EXACT [] +is_a: GO:0014006 ! regulation of microglia differentiation +is_a: GO:0045650 ! negative regulation of macrophage differentiation +is_a: GO:0045686 ! negative regulation of glial cell differentiation +relationship: negatively_regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014008 +name: positive regulation of microglia differentiation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] +synonym: "activation of microglia differentiation" NARROW [] +synonym: "positive regulation of microglial cell differentiation" EXACT [] +synonym: "stimulation of microglia differentiation" NARROW [] +synonym: "up regulation of microglia differentiation" EXACT [] +synonym: "up-regulation of microglia differentiation" EXACT [] +synonym: "upregulation of microglia differentiation" EXACT [] +is_a: GO:0014006 ! regulation of microglia differentiation +is_a: GO:0045651 ! positive regulation of macrophage differentiation +is_a: GO:0045687 ! positive regulation of glial cell differentiation +relationship: positively_regulates GO:0014004 ! microglia differentiation + +[Term] +id: GO:0014009 +name: glial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] +synonym: "glia proliferation" EXACT [] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0014010 +name: Schwann cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] +is_a: GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0014011 +name: Schwann cell proliferation involved in axon regeneration +namespace: biological_process +def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] +is_a: GO:0014010 ! Schwann cell proliferation +relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration + +[Term] +id: GO:0014012 +name: peripheral nervous system axon regeneration +namespace: biological_process +def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] +synonym: "axon regeneration in peripheral nervous system" EXACT [] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0014013 +name: regulation of gliogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +is_a: GO:0050767 ! regulation of neurogenesis +relationship: regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014014 +name: negative regulation of gliogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +synonym: "down regulation of gliogenesis" EXACT [] +synonym: "down-regulation of gliogenesis" EXACT [] +synonym: "downregulation of gliogenesis" EXACT [] +synonym: "inhibition of gliogenesis" NARROW [] +is_a: GO:0014013 ! regulation of gliogenesis +is_a: GO:0050768 ! negative regulation of neurogenesis +relationship: negatively_regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014015 +name: positive regulation of gliogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] +synonym: "activation of gliogenesis" NARROW [] +synonym: "stimulation of gliogenesis" NARROW [] +synonym: "up regulation of gliogenesis" EXACT [] +synonym: "up-regulation of gliogenesis" EXACT [] +synonym: "upregulation of gliogenesis" EXACT [] +is_a: GO:0014013 ! regulation of gliogenesis +is_a: GO:0050769 ! positive regulation of neurogenesis +relationship: positively_regulates GO:0042063 ! gliogenesis + +[Term] +id: GO:0014016 +name: neuroblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0014017 +name: neuroblast fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0014016 ! neuroblast differentiation + +[Term] +id: GO:0014018 +name: neuroblast fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0014017 ! neuroblast fate commitment + +[Term] +id: GO:0014019 +name: neuroblast development +namespace: biological_process +def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0014016 ! neuroblast differentiation + +[Term] +id: GO:0014020 +name: primary neural tube formation +namespace: biological_process +def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] +synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] +synonym: "primary neurulation" EXACT [] +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0014021 +name: secondary neural tube formation +namespace: biological_process +alt_id: GO:0014026 +def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585] +synonym: "medullary cord biosynthesis" EXACT [] +synonym: "medullary cord formation" EXACT [] +synonym: "neural rod formation" RELATED [] +synonym: "secondary neurulation" EXACT [] +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0014022 +name: neural plate elongation +namespace: biological_process +def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0014023 +name: neural rod formation +namespace: biological_process +def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0014024 +name: neural rod cavitation +namespace: biological_process +def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] +is_a: GO:0060605 ! tube lumen cavitation +relationship: part_of GO:0014020 ! primary neural tube formation + +[Term] +id: GO:0014025 +name: neural keel formation +namespace: biological_process +def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0014023 ! neural rod formation + +[Term] +id: GO:0014027 +name: secondary neural tube rod cavitation +namespace: biological_process +def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] +synonym: "medullary rod cavitation" EXACT [] +is_a: GO:0060605 ! tube lumen cavitation +relationship: part_of GO:0014021 ! secondary neural tube formation + +[Term] +id: GO:0014028 +name: notochord formation +namespace: biological_process +def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007399 ! nervous system development +relationship: part_of GO:0048570 ! notochord morphogenesis + +[Term] +id: GO:0014029 +name: neural crest formation +namespace: biological_process +def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef] +is_a: GO:0001837 ! epithelial to mesenchymal transition +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0014030 +name: mesenchymal cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0014031 +name: mesenchymal cell development +namespace: biological_process +def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0014032 +name: neural crest cell development +namespace: biological_process +def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] +is_a: GO:0014031 ! mesenchymal cell development +is_a: GO:0048864 ! stem cell development +relationship: part_of GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:0014033 +name: neural crest cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] +is_a: GO:0048762 ! mesenchymal cell differentiation +is_a: GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0014034 +name: neural crest cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef] +is_a: GO:0048865 ! stem cell fate commitment +relationship: part_of GO:0014029 ! neural crest formation +relationship: part_of GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:0014035 +name: neural crest cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef] +is_a: GO:0048867 ! stem cell fate determination +relationship: part_of GO:0014034 ! neural crest cell fate commitment + +[Term] +id: GO:0014036 +name: neural crest cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef] +is_a: GO:0048866 ! stem cell fate specification +relationship: part_of GO:0014034 ! neural crest cell fate commitment + +[Term] +id: GO:0014037 +name: Schwann cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0014038 +name: regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014039 +name: negative regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +synonym: "down regulation of Schwann cell differentiation" EXACT [] +synonym: "down-regulation of Schwann cell differentiation" EXACT [] +synonym: "downregulation of Schwann cell differentiation" EXACT [] +synonym: "inhibition of Schwann cell differentiation" NARROW [] +is_a: GO:0014038 ! regulation of Schwann cell differentiation +is_a: GO:0045686 ! negative regulation of glial cell differentiation +relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014040 +name: positive regulation of Schwann cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] +synonym: "activation of Schwann cell differentiation" NARROW [] +synonym: "stimulation of Schwann cell differentiation" NARROW [] +synonym: "up regulation of Schwann cell differentiation" EXACT [] +synonym: "up-regulation of Schwann cell differentiation" EXACT [] +synonym: "upregulation of Schwann cell differentiation" EXACT [] +is_a: GO:0014038 ! regulation of Schwann cell differentiation +is_a: GO:0045687 ! positive regulation of glial cell differentiation +relationship: positively_regulates GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014041 +name: regulation of neuron maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] +is_a: GO:0045664 ! regulation of neuron differentiation +is_a: GO:1903429 ! regulation of cell maturation +relationship: regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014042 +name: positive regulation of neuron maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] +synonym: "activation of neuron maturation" NARROW [] +synonym: "stimulation of neuron maturation" NARROW [] +synonym: "up regulation of neuron maturation" EXACT [] +synonym: "up-regulation of neuron maturation" EXACT [] +synonym: "upregulation of neuron maturation" EXACT [] +is_a: GO:0014041 ! regulation of neuron maturation +is_a: GO:1903431 ! positive regulation of cell maturation +relationship: positively_regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014043 +name: negative regulation of neuron maturation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] +synonym: "down regulation of neuron maturation" EXACT [] +synonym: "down-regulation of neuron maturation" EXACT [] +synonym: "downregulation of neuron maturation" EXACT [] +synonym: "inhibition of neuron maturation" NARROW [] +is_a: GO:0014041 ! regulation of neuron maturation +is_a: GO:1903430 ! negative regulation of cell maturation +relationship: negatively_regulates GO:0042551 ! neuron maturation + +[Term] +id: GO:0014044 +name: Schwann cell development +namespace: biological_process +def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0014037 ! Schwann cell differentiation + +[Term] +id: GO:0014045 +name: establishment of endothelial blood-brain barrier +namespace: biological_process +def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:aruk, GOC:dgh, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653] +synonym: "establishment of endothelial BBB" EXACT [] +synonym: "establishment of endothelial blood/brain barrier" EXACT [] +is_a: GO:0060856 ! establishment of blood-brain barrier +is_a: GO:0061028 ! establishment of endothelial barrier + +[Term] +id: GO:0014046 +name: dopamine secretion +namespace: biological_process +def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] +is_a: GO:0015872 ! dopamine transport +is_a: GO:0023061 ! signal release +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0014047 +name: glutamate secretion +namespace: biological_process +def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0014048 +name: regulation of glutamate secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051955 ! regulation of amino acid transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014049 +name: positive regulation of glutamate secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] +synonym: "activation of glutamate secretion" NARROW [] +synonym: "stimulation of glutamate secretion" NARROW [] +synonym: "up regulation of glutamate secretion" EXACT [] +synonym: "up-regulation of glutamate secretion" EXACT [] +synonym: "upregulation of glutamate secretion" EXACT [] +is_a: GO:0014048 ! regulation of glutamate secretion +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903532 ! positive regulation of secretion by cell +is_a: GO:1903793 ! positive regulation of anion transport +relationship: positively_regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014050 +name: negative regulation of glutamate secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] +synonym: "down regulation of glutamate secretion" EXACT [] +synonym: "down-regulation of glutamate secretion" EXACT [] +synonym: "downregulation of glutamate secretion" EXACT [] +synonym: "inhibition of glutamate secretion" NARROW [] +is_a: GO:0014048 ! regulation of glutamate secretion +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903531 ! negative regulation of secretion by cell +is_a: GO:1903792 ! negative regulation of anion transport +relationship: negatively_regulates GO:0014047 ! glutamate secretion + +[Term] +id: GO:0014051 +name: gamma-aminobutyric acid secretion +namespace: biological_process +def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] +synonym: "GABA secretion" EXACT [] +is_a: GO:0015812 ! gamma-aminobutyric acid transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0014052 +name: regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "regulation of GABA secretion" EXACT [] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014053 +name: negative regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] +synonym: "negative regulation of GABA secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903792 ! negative regulation of anion transport +relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014054 +name: positive regulation of gamma-aminobutyric acid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] +synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "positive regulation of GABA secretion" EXACT [] +synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] +synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] +synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] +is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903793 ! positive regulation of anion transport +relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion + +[Term] +id: GO:0014055 +name: acetylcholine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0061526 ! acetylcholine secretion +relationship: part_of GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0014056 +name: regulation of acetylcholine secretion, neurotransmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission + +[Term] +id: GO:0014057 +name: positive regulation of acetylcholine secretion, neurotransmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +synonym: "activation of acetylcholine secretion" NARROW [] +synonym: "stimulation of acetylcholine secretion" NARROW [] +synonym: "up regulation of acetylcholine secretion" EXACT [] +synonym: "up-regulation of acetylcholine secretion" EXACT [] +synonym: "upregulation of acetylcholine secretion" EXACT [] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission +is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission + +[Term] +id: GO:0014058 +name: negative regulation of acetylcholine secretion, neurotransmission +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] +synonym: "down regulation of acetylcholine secretion" EXACT [] +synonym: "down-regulation of acetylcholine secretion" EXACT [] +synonym: "downregulation of acetylcholine secretion" EXACT [] +synonym: "inhibition of acetylcholine secretion" NARROW [] +is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission +is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission + +[Term] +id: GO:0014059 +name: regulation of dopamine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0014060 +name: regulation of epinephrine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] +synonym: "regulation of adrenaline secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0014061 +name: regulation of norepinephrine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] +synonym: "regulation of noradrenaline secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +relationship: regulates GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0014062 +name: regulation of serotonin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +synonym: "regulation of serotonin release" RELATED [GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014063 +name: negative regulation of serotonin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +synonym: "down regulation of serotonin secretion" EXACT [] +synonym: "down-regulation of serotonin secretion" EXACT [] +synonym: "downregulation of serotonin secretion" EXACT [] +synonym: "inhibition of serotonin secretion" NARROW [] +synonym: "positive regulation of serotonin release" RELATED [GOC:tb] +is_a: GO:0014062 ! regulation of serotonin secretion +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014064 +name: positive regulation of serotonin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] +synonym: "activation of serotonin secretion" NARROW [] +synonym: "positive regulation of serotonin release" RELATED [GOC:tb] +synonym: "stimulation of serotonin secretion" NARROW [] +synonym: "up regulation of serotonin secretion" EXACT [] +synonym: "up-regulation of serotonin secretion" EXACT [] +synonym: "upregulation of serotonin secretion" EXACT [] +is_a: GO:0014062 ! regulation of serotonin secretion +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0001820 ! serotonin secretion + +[Term] +id: GO:0014065 +name: phosphatidylinositol 3-kinase signaling +namespace: biological_process +def: "A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K] +synonym: "phosphatidylinositol 3-kinase cascade" RELATED [GOC:signaling] +synonym: "phosphatidylinositol 3-kinase signal transduction" EXACT [GOC:signaling] +synonym: "phosphoinositide 3-kinase cascade" EXACT [] +synonym: "PI 3-kinase cascade" EXACT [] +synonym: "PI3K cascade" EXACT [] +synonym: "PI3K signal transduction" EXACT [GOC:signaling] +synonym: "PI3K signaling" EXACT [GOC:signaling] +is_a: GO:0048015 ! phosphatidylinositol-mediated signaling + +[Term] +id: GO:0014066 +name: regulation of phosphatidylinositol 3-kinase signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] +synonym: "regulation of phosphatidylinositol 3-kinase cascade" RELATED [] +synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "regulation of PI 3-kinase cascade" RELATED [] +synonym: "regulation of PI3K cascade" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling + +[Term] +id: GO:0014067 +name: negative regulation of phosphatidylinositol 3-kinase signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] +synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT [] +synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] +synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT [] +synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW [] +synonym: "negative regulation of phosphatidylinositol 3-kinase cascade" RELATED [] +synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "negative regulation of PI 3-kinase cascade" EXACT [] +synonym: "negative regulation of PI3K cascade" EXACT [] +is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling + +[Term] +id: GO:0014068 +name: positive regulation of phosphatidylinositol 3-kinase signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] +synonym: "activation of phosphoinositide 3-kinase cascade" NARROW [] +synonym: "positive regulation of phosphatidylinositol 3-kinase cascade" RELATED [] +synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT [] +synonym: "positive regulation of PI 3-kinase cascade" EXACT [] +synonym: "positive regulation of PI3K cascade" EXACT [] +synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW [] +synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT [] +synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] +synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT [] +is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling + +[Term] +id: GO:0014069 +name: postsynaptic density +namespace: cellular_component +alt_id: GO:0097481 +alt_id: GO:0097483 +def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] +subset: goslim_synapse +synonym: "neuronal postsynaptic density" EXACT [GO:0097481] +synonym: "post synaptic density" EXACT [] +synonym: "post-synaptic density" EXACT [] +synonym: "postsynaptic density of dendrite" NARROW [] +xref: NIF_Subcellular:sao1196688972 +xref: Wikipedia:Postsynaptic_density +is_a: GO:0099572 ! postsynaptic specialization +relationship: part_of GO:0032279 ! asymmetric synapse + +[Term] +id: GO:0014070 +name: response to organic cyclic compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:ef] +synonym: "response to organic cyclic substance" EXACT [GOC:mah] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0014071 +name: response to cycloalkane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:ef] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0014072 +name: response to isoquinoline alkaloid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:ef] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0014073 +name: response to tropane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:ef] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0014074 +name: response to purine-containing compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:ef] +synonym: "response to purine" RELATED [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0014075 +name: response to amine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:ef] +synonym: "response to amine stimulus" EXACT [GOC:dos] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0014076 +name: response to fluoxetine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:ef, GOC:pr] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to selective serotonin reuptake inhibitor" RELATED [] +synonym: "response to SSRI" RELATED [] +is_a: GO:0036276 ! response to antidepressant + +[Term] +id: GO:0014701 +name: junctional sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] +is_a: GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:0014702 +name: free sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] +is_a: GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:0014703 +name: oscillatory muscle contraction +namespace: biological_process +def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014704 +name: intercalated disc +namespace: cellular_component +def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] +synonym: "intercalated disk" EXACT [] +xref: Wikipedia:Intercalated_disc +is_a: GO:0044291 ! cell-cell contact zone + +[Term] +id: GO:0014705 +name: C zone +namespace: cellular_component +def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0014706 +name: striated muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] +is_a: GO:0060537 ! muscle tissue development + +[Term] +id: GO:0014707 +name: branchiomeric skeletal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] +is_a: GO:0007517 ! muscle organ development +is_a: GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0014708 +name: regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle] +is_a: GO:0048634 ! regulation of muscle organ development +relationship: regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014709 +name: positive regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014708 ! regulation of somitomeric trunk muscle development +is_a: GO:0048636 ! positive regulation of muscle organ development +relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014710 +name: negative regulation of somitomeric trunk muscle development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014708 ! regulation of somitomeric trunk muscle development +is_a: GO:0048635 ! negative regulation of muscle organ development +relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development + +[Term] +id: GO:0014711 +name: regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0048641 ! regulation of skeletal muscle tissue development +relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014712 +name: positive regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development +is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development +relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014713 +name: negative regulation of branchiomeric skeletal muscle development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] +is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development +is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development +relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development + +[Term] +id: GO:0014714 +name: myoblast fate commitment in head +namespace: biological_process +def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048625 ! myoblast fate commitment + +[Term] +id: GO:0014715 +name: myoblast fate commitment in trunk +namespace: biological_process +def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048625 ! myoblast fate commitment + +[Term] +id: GO:0014716 +name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration +namespace: biological_process +def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle] +comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class. +synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT [] +is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division +relationship: part_of GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration + +[Term] +id: GO:0014717 +name: regulation of satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] +is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014718 +name: positive regulation of satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] +is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration +is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration +is_a: GO:0050867 ! positive regulation of cell activation +relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014719 +name: skeletal muscle satellite cell activation +namespace: biological_process +def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0014720 +name: tonic skeletal muscle contraction +namespace: biological_process +def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014721 +name: twitch skeletal muscle contraction +namespace: biological_process +def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle] +is_a: GO:0003010 ! voluntary skeletal muscle contraction + +[Term] +id: GO:0014722 +name: regulation of skeletal muscle contraction by calcium ion signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] +synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +is_a: GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0014723 +name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle] +synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT [] +is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling + +[Term] +id: GO:0014724 +name: regulation of twitch skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +relationship: regulates GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0014725 +name: regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0048641 ! regulation of skeletal muscle tissue development +relationship: regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014726 +name: negative regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014725 ! regulation of extraocular skeletal muscle development +is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development +relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014727 +name: positive regulation of extraocular skeletal muscle development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] +is_a: GO:0014725 ! regulation of extraocular skeletal muscle development +is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development +relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development + +[Term] +id: GO:0014728 +name: regulation of the force of skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle] +is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion + +[Term] +id: GO:0014729 +name: regulation of the velocity of shortening of skeletal muscle modulating contraction +namespace: biological_process +def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle] +synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph] +is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0014730 +name: skeletal muscle regeneration at neuromuscular junction +namespace: biological_process +def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle] +is_a: GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014731 +name: spectrin-associated cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0014732 +name: skeletal muscle atrophy +namespace: biological_process +def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014891 ! striated muscle atrophy +is_a: GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014733 +name: regulation of skeletal muscle adaptation +namespace: biological_process +def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "regulation of skeletal muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014734 +name: skeletal muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] +is_a: GO:0014897 ! striated muscle hypertrophy +is_a: GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0014735 +name: regulation of muscle atrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014736 +name: negative regulation of muscle atrophy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0014735 ! regulation of muscle atrophy +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014737 +name: positive regulation of muscle atrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] +is_a: GO:0014735 ! regulation of muscle atrophy +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014738 +name: regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014739 +name: positive regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0014744 ! positive regulation of muscle adaptation +relationship: positively_regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014740 +name: negative regulation of muscle hyperplasia +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0014745 ! negative regulation of muscle adaptation +relationship: negatively_regulates GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014741 +name: negative regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014742 +name: positive regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014743 +name: regulation of muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] +is_a: GO:0090257 ! regulation of muscle system process +relationship: regulates GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014744 +name: positive regulation of muscle adaptation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] +synonym: "positive regulation of muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014745 +name: negative regulation of muscle adaptation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] +synonym: "negative regulation of muscle plasticity" RELATED [] +is_a: GO:0043502 ! regulation of muscle adaptation +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014746 +name: regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +relationship: regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014747 +name: positive regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014748 +name: negative regulation of tonic skeletal muscle contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction + +[Term] +id: GO:0014801 +name: longitudinal sarcoplasmic reticulum +namespace: cellular_component +def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0014802 +name: terminal cisterna +namespace: cellular_component +def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] +xref: Wikipedia:Terminal_cisterna +is_a: GO:0098827 ! endoplasmic reticulum subcompartment +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0014803 +name: longitudinal sarcoplasmic reticulum lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle] +is_a: GO:0033018 ! sarcoplasmic reticulum lumen +relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum + +[Term] +id: GO:0014804 +name: terminal cisterna lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] +is_a: GO:0033018 ! sarcoplasmic reticulum lumen +relationship: part_of GO:0014802 ! terminal cisterna + +[Term] +id: GO:0014805 +name: smooth muscle adaptation +namespace: biological_process +def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "smooth muscle plasticity" RELATED [] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014806 +name: smooth muscle hyperplasia +namespace: biological_process +def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation +is_a: GO:0014900 ! muscle hyperplasia + +[Term] +id: GO:0014807 +name: regulation of somitogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001756 ! somitogenesis + +[Term] +id: GO:0014808 +name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum +namespace: biological_process +def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle] +synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb] +is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport +is_a: GO:1903514 ! release of sequestered calcium ion into cytosol by endoplasmic reticulum + +[Term] +id: GO:0014809 +name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] +is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum +is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling + +[Term] +id: GO:0014810 +name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] +is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion +is_a: GO:0045989 ! positive regulation of striated muscle contraction + +[Term] +id: GO:0014811 +name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] +is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion +is_a: GO:0045988 ! negative regulation of striated muscle contraction + +[Term] +id: GO:0014812 +name: muscle cell migration +namespace: biological_process +def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0014813 +name: skeletal muscle satellite cell commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0014816 ! skeletal muscle satellite cell differentiation + +[Term] +id: GO:0014814 +name: axon regeneration at neuromuscular junction +namespace: biological_process +def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0014815 +name: initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration +namespace: biological_process +def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:0014816 +name: skeletal muscle satellite cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0035914 ! skeletal muscle cell differentiation + +[Term] +id: GO:0014817 +name: skeletal muscle satellite cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment + +[Term] +id: GO:0014818 +name: skeletal muscle satellite cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0048867 ! stem cell fate determination +relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment + +[Term] +id: GO:0014819 +name: regulation of skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0006942 ! regulation of striated muscle contraction +relationship: regulates GO:0003009 ! skeletal muscle contraction + +[Term] +id: GO:0014820 +name: tonic smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014821 +name: phasic smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014822 +name: detection of wounding +namespace: biological_process +def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle] +synonym: "detection of injury" EXACT [] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0014823 +name: response to activity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle] +synonym: "response to exercise" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0014824 +name: artery smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158] +is_a: GO:0014820 ! tonic smooth muscle contraction +is_a: GO:0014829 ! vascular associated smooth muscle contraction + +[Term] +id: GO:0014825 +name: stomach fundus smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612] +is_a: GO:0014847 ! proximal stomach smooth muscle contraction + +[Term] +id: GO:0014826 +name: vein smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014829 ! vascular associated smooth muscle contraction + +[Term] +id: GO:0014827 +name: intestine smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014828 +name: distal stomach smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, PMID:30252381] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0120063 ! stomach smooth muscle contraction + +[Term] +id: GO:0014829 +name: vascular associated smooth muscle contraction +namespace: biological_process +def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] +synonym: "vascular smooth muscle contraction" EXACT [] +is_a: GO:0006939 ! smooth muscle contraction +is_a: GO:0042310 ! vasoconstriction + +[Term] +id: GO:0014830 +name: arteriole smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MSH:D001160] +is_a: GO:0014824 ! artery smooth muscle contraction + +[Term] +id: GO:0014831 +name: gastro-intestinal system smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014832 +name: urinary bladder smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, PMID:11768524, PMID:18276178, PMID:538956] +is_a: GO:0014848 ! urinary tract smooth muscle contraction + +[Term] +id: GO:0014833 +name: skeletal muscle satellite stem cell asymmetric division +namespace: biological_process +def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +synonym: "satellite cell asymmetric division" EXACT [] +is_a: GO:0048103 ! somatic stem cell division +is_a: GO:0098722 ! asymmetric stem cell division +relationship: part_of GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0014834 +name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905] +synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] +synonym: "satellite cell population maintenance" EXACT [] +synonym: "satellite cell self-renewal" BROAD [] +is_a: GO:0098727 ! maintenance of cell number +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014835 +name: myoblast differentiation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0045445 ! myoblast differentiation +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014836 +name: myoblast fate commitment involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0048625 ! myoblast fate commitment +relationship: part_of GO:0014835 ! myoblast differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014837 +name: myoblast fate determination involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0007518 ! myoblast fate determination +relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration + +[Term] +id: GO:0014838 +name: myoblast fate specification involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0048626 ! myoblast fate specification +relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration + +[Term] +id: GO:0014839 +name: myoblast migration involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] +is_a: GO:0051451 ! myoblast migration +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014841 +name: skeletal muscle satellite cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014842 +name: regulation of skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation +relationship: regulates GO:0014841 ! skeletal muscle satellite cell proliferation + +[Term] +id: GO:0014843 +name: growth factor dependent regulation of skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation + +[Term] +id: GO:0014844 +name: myoblast proliferation involved in skeletal muscle regeneration +namespace: biological_process +def: "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] +is_a: GO:0051450 ! myoblast proliferation +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014845 +name: stomach body smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559] +is_a: GO:0014828 ! distal stomach smooth muscle contraction + +[Term] +id: GO:0014846 +name: esophagus smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742] +synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph] +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0014847 +name: proximal stomach smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, PMID:30252381] +is_a: GO:0014820 ! tonic smooth muscle contraction +is_a: GO:0120063 ! stomach smooth muscle contraction + +[Term] +id: GO:0014848 +name: urinary tract smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0014849 +name: ureter smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] +is_a: GO:0014821 ! phasic smooth muscle contraction +is_a: GO:0014848 ! urinary tract smooth muscle contraction + +[Term] +id: GO:0014850 +name: response to muscle activity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle] +is_a: GO:0014823 ! response to activity + +[Term] +id: GO:0014852 +name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014853 +name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction +namespace: biological_process +def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] +synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT [] +is_a: GO:0098815 ! modulation of excitatory postsynaptic potential +relationship: part_of GO:0003009 ! skeletal muscle contraction +relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction + +[Term] +id: GO:0014854 +name: response to inactivity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0014855 +name: striated muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] +is_a: GO:0033002 ! muscle cell proliferation + +[Term] +id: GO:0014856 +name: skeletal muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0014855 ! striated muscle cell proliferation + +[Term] +id: GO:0014857 +name: regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014858 +name: positive regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation +relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014859 +name: negative regulation of skeletal muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation +relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation + +[Term] +id: GO:0014860 +name: neurotransmitter secretion involved in regulation of skeletal muscle contraction +namespace: biological_process +def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] +synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007269 ! neurotransmitter secretion +relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction + +[Term] +id: GO:0014861 +name: regulation of skeletal muscle contraction via regulation of action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] +synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] +is_a: GO:0014819 ! regulation of skeletal muscle contraction +is_a: GO:0098900 ! regulation of action potential +relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential + +[Term] +id: GO:0014862 +name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle] +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0014863 +name: detection of inactivity +namespace: biological_process +def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014854 ! response to inactivity +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0014864 +name: detection of muscle activity +namespace: biological_process +def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014850 ! response to muscle activity +is_a: GO:0014865 ! detection of activity + +[Term] +id: GO:0014865 +name: detection of activity +namespace: biological_process +def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014823 ! response to activity +is_a: GO:0051606 ! detection of stimulus + +[Term] +id: GO:0014866 +name: skeletal myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0030239 ! myofibril assembly + +[Term] +id: GO:0014868 +name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction + +[Term] +id: GO:0014869 +name: detection of muscle inactivity +namespace: biological_process +def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] +is_a: GO:0014863 ! detection of inactivity +is_a: GO:0014870 ! response to muscle inactivity + +[Term] +id: GO:0014870 +name: response to muscle inactivity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle] +is_a: GO:0014854 ! response to inactivity + +[Term] +id: GO:0014871 +name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction + +[Term] +id: GO:0014872 +name: myoblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0014873 +name: response to muscle activity involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to fatigue" EXACT [] +synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014850 ! response to muscle activity +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014874 +name: response to stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0050896 ! response to stimulus +relationship: part_of GO:0043502 ! regulation of muscle adaptation + +[Term] +id: GO:0014875 +name: detection of muscle activity involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "detection of fatigue" EXACT [] +is_a: GO:0014864 ! detection of muscle activity +is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation + +[Term] +id: GO:0014876 +name: response to injury involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to injury involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0009611 ! response to wounding +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014877 +name: response to muscle inactivity involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014870 ! response to muscle inactivity +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation + +[Term] +id: GO:0014878 +name: response to electrical stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation +is_a: GO:0051602 ! response to electrical stimulus + +[Term] +id: GO:0014879 +name: detection of electrical stimulus involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation +is_a: GO:0050981 ! detection of electrical stimulus + +[Term] +id: GO:0014880 +name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] +is_a: GO:0032971 ! regulation of muscle filament sliding +relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction + +[Term] +id: GO:0014881 +name: regulation of myofibril size +namespace: biological_process +def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] +synonym: "change of myofibril size" EXACT [] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0014882 +name: regulation of myofibril number +namespace: biological_process +def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] +synonym: "change of myofibril number" EXACT [] +is_a: GO:0014738 ! regulation of muscle hyperplasia +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0014883 +name: transition between fast and slow fiber +namespace: biological_process +def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] +synonym: "transition between fast and slow fibre" EXACT [] +synonym: "transition fast-slow fiber" EXACT [] +synonym: "transition fast-slow fibre" EXACT [] +is_a: GO:0014733 ! regulation of skeletal muscle adaptation + +[Term] +id: GO:0014884 +name: detection of muscle inactivity involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +is_a: GO:0014869 ! detection of muscle inactivity +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014885 +name: detection of injury involved in regulation of muscle adaptation +namespace: biological_process +def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] +synonym: "detection of injury involved in regulation of muscle plasticity" RELATED [] +is_a: GO:0014822 ! detection of wounding +is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation + +[Term] +id: GO:0014886 +name: transition between slow and fast fiber +namespace: biological_process +def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] +synonym: "transition between slow and fast fibre" EXACT [] +synonym: "transition slow-fast fiber" EXACT [] +synonym: "transition slow-fast fibre" EXACT [] +is_a: GO:0014733 ! regulation of skeletal muscle adaptation + +[Term] +id: GO:0014887 +name: cardiac muscle adaptation +namespace: biological_process +def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] +synonym: "cardiac muscle plasticity" RELATED [] +is_a: GO:0014888 ! striated muscle adaptation + +[Term] +id: GO:0014888 +name: striated muscle adaptation +namespace: biological_process +def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] +synonym: "striated muscle plasticity" RELATED [] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014889 +name: muscle atrophy +namespace: biological_process +def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +comment: GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process. +xref: Wikipedia:Muscle_atrophy +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014890 +name: smooth muscle atrophy +namespace: biological_process +def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation +is_a: GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014891 +name: striated muscle atrophy +namespace: biological_process +def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] +is_a: GO:0014888 ! striated muscle adaptation +is_a: GO:0014889 ! muscle atrophy + +[Term] +id: GO:0014893 +name: response to rest involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014894 +name: response to denervation involved in regulation of muscle adaptation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] +is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation + +[Term] +id: GO:0014895 +name: smooth muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] +is_a: GO:0014805 ! smooth muscle adaptation +is_a: GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014896 +name: muscle hypertrophy +namespace: biological_process +def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] +xref: Wikipedia:Muscle_hypertrophy +is_a: GO:0003012 ! muscle system process + +[Term] +id: GO:0014897 +name: striated muscle hypertrophy +namespace: biological_process +def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] +is_a: GO:0014896 ! muscle hypertrophy + +[Term] +id: GO:0014898 +name: cardiac muscle hypertrophy in response to stress +namespace: biological_process +def: "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] +is_a: GO:0003299 ! muscle hypertrophy in response to stress +is_a: GO:0003300 ! cardiac muscle hypertrophy +is_a: GO:0014887 ! cardiac muscle adaptation + +[Term] +id: GO:0014899 +name: cardiac muscle atrophy +namespace: biological_process +def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] +is_a: GO:0014887 ! cardiac muscle adaptation +is_a: GO:0014891 ! striated muscle atrophy + +[Term] +id: GO:0014900 +name: muscle hyperplasia +namespace: biological_process +def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] +is_a: GO:0043500 ! muscle adaptation + +[Term] +id: GO:0014901 +name: satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] +is_a: GO:0014719 ! skeletal muscle satellite cell activation +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014902 +name: myotube differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0014904 +name: myotube cell development +namespace: biological_process +def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0055001 ! muscle cell development +relationship: part_of GO:0014902 ! myotube differentiation + +[Term] +id: GO:0014905 +name: myoblast fusion involved in skeletal muscle regeneration +namespace: biological_process +def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0007520 ! myoblast fusion +relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014906 +name: myotube cell development involved in skeletal muscle regeneration +namespace: biological_process +def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0014904 ! myotube cell development +relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration + +[Term] +id: GO:0014908 +name: myotube differentiation involved in skeletal muscle regeneration +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] +is_a: GO:0014902 ! myotube differentiation +relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0014909 +name: smooth muscle cell migration +namespace: biological_process +def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014812 ! muscle cell migration + +[Term] +id: GO:0014910 +name: regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014911 +name: positive regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +is_a: GO:0030335 ! positive regulation of cell migration +relationship: positively_regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014912 +name: negative regulation of smooth muscle cell migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +is_a: GO:0030336 ! negative regulation of cell migration +relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:0014914 +name: myoblast maturation involved in muscle regeneration +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] +is_a: GO:0048628 ! myoblast maturation + +[Term] +id: GO:0014915 +name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction +namespace: biological_process +def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] +is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction +is_a: GO:0032972 ! regulation of muscle filament sliding speed + +[Term] +id: GO:0014916 +name: regulation of lung blood pressure +namespace: biological_process +def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] +synonym: "regulation of pulmonary blood pressure" EXACT [] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0014917 +name: obsolete positive regulation of diuresis by pressure natriuresis +namespace: biological_process +def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "positive regulation of diuresis by pressure natriuresis" EXACT [] +is_obsolete: true +replaced_by: GO:0035818 + +[Term] +id: GO:0014918 +name: obsolete positive regulation of natriuresis by pressure natriuresis +namespace: biological_process +def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "positive regulation of natriuresis by pressure natriuresis" EXACT [] +is_obsolete: true +replaced_by: GO:0035819 + +[Term] +id: GO:0015000 +name: obsolete polyferredoxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a function. +synonym: "polyferredoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015001 +name: obsolete high-potential iron-sulfur carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "high-potential iron-sulfur carrier" EXACT [] +synonym: "high-potential iron-sulphur carrier" EXACT [] +synonym: "HiPIP" RELATED [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015002 +name: obsolete heme-copper terminal oxidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] +comment: This term was obsoleted because it groups the last enzymes in the electron transport chain, and is not an appropriate grouping term for molecular function. +synonym: "haem-copper terminal oxidase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015003 +name: obsolete copper electron carrier +namespace: molecular_function +def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "copper electron carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015004 +name: obsolete small blue copper electron carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "small blue copper electron carrier" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015005 +name: obsolete azurin +namespace: molecular_function +def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "azurin" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0015006 +name: obsolete plastocyanin +namespace: molecular_function +def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "plastocyanin" EXACT [] +is_obsolete: true +replaced_by: GO:0046028 + +[Term] +id: GO:0015007 +name: obsolete electron carrier, chlorophyll electron transport system +namespace: molecular_function +def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732] +comment: This term was made obsolete because it contains both process and function information. +synonym: "chlorophyll electron carrier" RELATED [] +synonym: "electron carrier, chlorophyll electron transport system" EXACT [] +is_obsolete: true +consider: GO:0009055 +consider: GO:0009767 + +[Term] +id: GO:0015009 +name: corrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732] +synonym: "corrin metabolism" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0015010 +name: tetrahydrocorphin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [Wikipedia:Morphine] +synonym: "tetrahydrocorphin metabolism" EXACT [] +is_a: GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process + +[Term] +id: GO:0015011 +name: nickel-tetrapyrrole coenzyme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, Wikipedia:Cofactor_F430] +synonym: "coenzyme F430 metabolic process" NARROW [] +synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0015012 +name: heparan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] +synonym: "heparan sulfate proteoglycan anabolism" EXACT [] +synonym: "heparan sulfate proteoglycan biosynthesis" EXACT [] +synonym: "heparan sulfate proteoglycan formation" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT [] +synonym: "heparin proteoglycan biosynthetic process" RELATED [] +xref: RESID:AA0210 +is_a: GO:0030166 ! proteoglycan biosynthetic process +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process + +[Term] +id: GO:0015013 +name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide +namespace: biological_process +def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194] +synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT [] +synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED [] +is_a: GO:0018242 ! protein O-linked glycosylation via serine +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015014 +name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] +synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "heparan sulfate proteoglycan chain elongation" EXACT [] +synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015015 +name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification +namespace: biological_process +def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194] +synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT [] +synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT [] +synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT [] +synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT [] +synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED [] +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process +relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0015016 +name: [heparan sulfate]-glucosamine N-sulfotransferase activity +namespace: molecular_function +alt_id: GO:0004393 +alt_id: GO:0015022 +alt_id: GO:0051910 +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8] +comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] +synonym: "desulfoheparin sulfotransferase activity" EXACT [] +synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "heparan sulfate 2-N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "heparan sulfate N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] +synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] +synonym: "heparin N-sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT [] +synonym: "heparitin N-sulfotransferase activity" EXACT [] +synonym: "heparitin N-sulphotransferase activity" EXACT [] +synonym: "heparitin sulfotransferase activity" EXACT [] +synonym: "N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "N-heparan sulfate sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "N-HSST activity" RELATED [EC:2.8.2.8] +synonym: "PAPS:DSH sulfotransferase activity" RELATED [EC:2.8.2.8] +synonym: "PAPS:N-desulfoheparin sulfotransferase activity" RELATED [EC:2.8.2.8] +xref: EC:2.8.2.8 +xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)" +xref: RHEA:21980 +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0015017 +name: obsolete glypican +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan'). +synonym: "glypican" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015018 +name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] +synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] +synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" RELATED [EC:2.4.1.135] +synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" RELATED [EC:2.4.1.135] +synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" RELATED [EC:2.4.1.135] +xref: EC:2.4.1.135 +xref: MetaCyc:2.4.1.135-RXN +xref: Reactome:R-HSA-1889955 "B3GAT dimers transfer GlcA to tetrasaccharide linker" +xref: Reactome:R-HSA-3560802 "Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker" +xref: Reactome:R-HSA-9638064 "B3GAT3 dimer transfers GlcA to tetrasaccharide linker" +xref: RHEA:24168 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0015019 +name: heparan-alpha-glucosaminide N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] +synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" RELATED [EC:2.3.1.78] +synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" RELATED [EC:2.3.1.78] +synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED [] +xref: EC:2.3.1.78 +xref: MetaCyc:2.3.1.78-RXN +xref: Reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3)" +xref: Reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)" +xref: Reactome:R-HSA-2263492 "Defective HGSNAT does not acetylate Heparan chain(1)" +xref: Reactome:R-HSA-9036056 "Defective HGSNAT does not acetylate Heparan sulfate chain(3)" +xref: RHEA:15125 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0015020 +name: glucuronosyltransferase activity +namespace: molecular_function +alt_id: GO:0003981 +def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [RHEA:21032] +synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "GT activity" RELATED [EC:2.4.1.17] +synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] +synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP glucuronic acid transferase activity" RELATED [EC:2.4.1.17] +synonym: "UDP glucuronosyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "UDP glucuronyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" RELATED [EC:2.4.1.17] +synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "UDP-glucuronosyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "UDP-glucuronyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "UDPGA transferase activity" RELATED [EC:2.4.1.17] +synonym: "UDPGA-glucuronyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [EC:2.4.1.17] +synonym: "UDPGT activity" RELATED [EC:2.4.1.17] +synonym: "uridine 5'-diphosphoglucuronyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "uridine diphosphate glucuronyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronosyltransferase activity" RELATED [EC:2.4.1.17] +synonym: "uridine diphosphoglucuronyltransferase activity" RELATED [EC:2.4.1.17] +xref: EC:2.4.1.17 +xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-159179 "UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG" +xref: Reactome:R-HSA-159194 "UGT1A4 transfers GlcA from UDP-GlcA to BIL to form BMG" +xref: Reactome:R-HSA-174916 "Formation of N-glucuronides" +xref: Reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates" +xref: Reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP" +xref: Reactome:R-HSA-5604954 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BIL" +xref: Reactome:R-HSA-5604975 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BIL" +xref: Reactome:R-HSA-5617143 "B4GAT1:GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA" +xref: Reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN" +xref: Reactome:R-HSA-9036102 "Defective UGT1A1 does not transfer GlcA from UDP-GlcA to BMG" +xref: Reactome:R-HSA-9036104 "Defective UGT1A4 does not transfer GlcA from UDP-GlcA to BMG" +xref: Reactome:R-HSA-9632038 "UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG" +xref: Reactome:R-HSA-9632039 "UGT1A1 transfers GlcA from UDP-GlcA to BIL to form BMG" +xref: Reactome:R-HSA-9638097 "B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA" +xref: RHEA:21032 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0015021 +name: heparin-sulfate lyase activity +namespace: molecular_function +def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] +synonym: "[heparan sulfate]-sulfate lyase activity" RELATED [] +synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] +synonym: "heparin-sulphate lyase activity" EXACT [] +synonym: "heparitin-sulfate lyase activity" EXACT [] +synonym: "heparitinase I" RELATED [EC:4.2.2.8] +synonym: "heparitinase II" RELATED [EC:4.2.2.8] +xref: EC:4.2.2.8 +xref: MetaCyc:4.2.2.8-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0015023 +name: obsolete syndecan +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "syndecan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015024 +name: glucuronate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] +synonym: "chondro-2-sulfatase activity" RELATED [EC:3.1.6.18] +synonym: "glucuronate-2-sulphatase activity" EXACT [] +synonym: "glucurono-2-sulfatase activity" RELATED [EC:3.1.6.18] +synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" RELATED [EC:3.1.6.18] +xref: EC:3.1.6.18 +xref: MetaCyc:3.1.6.18-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0015025 +name: obsolete GPI-anchored membrane-bound receptor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "GPI-anchored membrane-bound receptor" EXACT [] +is_obsolete: true +replaced_by: GO:0031225 + +[Term] +id: GO:0015026 +name: coreceptor activity +namespace: molecular_function +alt_id: GO:0015027 +alt_id: GO:0015028 +def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] +synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah] +synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0015029 +name: obsolete internalization receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind. +synonym: "internalization receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015030 +name: Cajal body +namespace: cellular_component +def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] +synonym: "coiled body" EXACT [] +synonym: "Gemini of coiled bodies" RELATED [] +synonym: "Gems" RELATED [] +xref: NIF_Subcellular:nlx_subcell_090901 +xref: Wikipedia:Cajal_body +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0015031 +name: protein transport +namespace: biological_process +alt_id: GO:0015831 +def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_chembl +subset: goslim_pir +subset: goslim_yeast +synonym: "enzyme transport" NARROW [] +is_a: GO:0045184 ! establishment of protein localization +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015032 +name: obsolete storage protein import into fat body +namespace: biological_process +def: "OBSOLETE. The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363] +comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using 'receptor-mediated endocytosis'. +synonym: "fat body metabolic process" BROAD [] +synonym: "fat body metabolism" BROAD [] +synonym: "fat body storage protein uptake" EXACT [] +synonym: "import of storage protein into fat body" EXACT [] +synonym: "storage protein import by fat body cells" EXACT [] +synonym: "storage protein import into fat body cells" EXACT [] +synonym: "storage protein transport into fat body cells" EXACT [] +synonym: "storage protein uptake into fat body cells" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015034 +name: obsolete cytochrome P450 activity +namespace: molecular_function +def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423] +comment: This term was made obsolete because it is a grouping term representing a set of gene products. +synonym: "cytochrome P450 activity" EXACT [] +is_obsolete: true +consider: GO:0019825 + +[Term] +id: GO:0015035 +name: protein-disulfide reductase activity +namespace: molecular_function +alt_id: GO:0008895 +alt_id: GO:0015037 +def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [PMID:7559385] +synonym: "haem lyase disulphide oxidoreductase activity" NARROW [] +synonym: "heme lyase disulfide oxidoreductase activity" NARROW [] +synonym: "peptide disulfide oxidoreductase activity" EXACT [] +synonym: "peptide disulphide oxidoreductase activity" EXACT [] +synonym: "protein disulfide oxidoreductase activity" EXACT [] +synonym: "protein disulfide-oxidoreductase activity" EXACT [] +synonym: "protein disulphide oxidoreductase activity" EXACT [] +xref: MetaCyc:DISULFOXRED-RXN +xref: Reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds" +xref: Reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1" +is_a: GO:0015036 ! disulfide oxidoreductase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0015036 +name: disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [GOC:curators] +synonym: "disulphide oxidoreductase activity" EXACT [] +xref: Reactome:R-HSA-1222417 "TrxA reactivates AhpC" +xref: Reactome:R-HSA-1222644 "TrxA/B1 reactivates Tpx" +xref: Reactome:R-HSA-1222655 "AhpD reactivates AhpC" +xref: Reactome:R-HSA-1222690 "DlaT reactivates AhpD" +xref: Reactome:R-HSA-264997 "Oxidation of cysteine to cystine in Proinsulin" +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0015038 +name: glutathione disulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] +synonym: "glutaredoxin" RELATED [] +synonym: "glutathione disulphide oxidoreductase activity" EXACT [] +xref: Reactome:R-HSA-111746 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)" +is_a: GO:0015036 ! disulfide oxidoreductase activity + +[Term] +id: GO:0015039 +name: NADPH-adrenodoxin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [GOC:kd, RHEA:42312] +comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. +synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] +synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] +synonym: "NADPH:adrenodoxin oxidoreductase activity" RELATED [EC:1.18.1.2] +xref: EC:1.18.1.6 +xref: MetaCyc:RXN-13685 +xref: RHEA:42312 +is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor + +[Term] +id: GO:0015040 +name: obsolete electron transfer flavoprotein, group I +namespace: molecular_function +def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "electron transfer flavoprotein, group I" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015041 +name: obsolete electron transfer flavoprotein, group II +namespace: molecular_function +def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "electron transfer flavoprotein, group II" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015042 +name: trypanothione-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [RHEA:16757] +comment: Note that this function was formerly EC:1.6.4.8. +synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" RELATED [EC:1.8.1.12] +synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" RELATED [EC:1.8.1.12] +synonym: "NADPH:trypanothione oxidoreductase activity" RELATED [EC:1.8.1.12] +synonym: "trypanothione reductase activity" EXACT [] +synonym: "trypanothione-disulphide reductase activity" EXACT [] +synonym: "trypanothione:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.12] +xref: EC:1.8.1.12 +xref: MetaCyc:1.8.1.12-RXN +xref: RHEA:16757 +is_a: GO:0015036 ! disulfide oxidoreductase activity +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0015043 +name: leghemoglobin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] +synonym: "ferric leghemoglobin reductase activity" RELATED [EC:1.6.2.6] +synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" RELATED [EC:1.6.2.6] +xref: EC:1.6.2.6 +xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN +is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor + +[Term] +id: GO:0015044 +name: rubredoxin-NAD+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [RHEA:18597] +synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" RELATED [EC:1.18.1.1] +synonym: "DPNH-rubredoxin reductase activity" RELATED [EC:1.18.1.1] +synonym: "NADH--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.1] +synonym: "NADH--rubredoxin reductase activity" RELATED [EC:1.18.1.1] +synonym: "NADH:rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.1] +synonym: "NADH:rubredoxin reductase activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" RELATED [EC:1.18.1.1] +synonym: "rubredoxin--NAD reductase activity" RELATED [EC:1.18.1.1] +synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" RELATED [EC:1.18.1.1] +synonym: "rubredoxin:NAD+ oxidoreductase activity" RELATED [EC:1.18.1.1] +xref: EC:1.18.1.1 +xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN +xref: RHEA:18597 +is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity + +[Term] +id: GO:0015045 +name: rubredoxin-NAD(P)+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] +synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] +synonym: "NAD(P)--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.4] +synonym: "NAD(P)H--rubredoxin oxidoreductase activity" RELATED [EC:1.18.1.4] +synonym: "NADPH:rubredoxin reductase activity" EXACT [] +synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] +synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" RELATED [EC:1.18.1.4] +synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" RELATED [EC:1.18.1.4] +xref: EC:1.18.1.4 +xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN +is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor + +[Term] +id: GO:0015046 +name: rubredoxin-NADP+ reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [RHEA:13949] +xref: EC:1.18.1.4 +xref: RHEA:13949 +is_a: GO:0015045 ! rubredoxin-NAD(P)+ reductase activity + +[Term] +id: GO:0015047 +name: NADPH-cytochrome-c2 reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] +synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" RELATED [EC:1.6.2.5] +synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" RELATED [EC:1.6.2.5] +synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.6.2.5] +xref: EC:1.6.2.5 +xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN +xref: RHEA:15237 +is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor + +[Term] +id: GO:0015048 +name: phthalate dioxygenase reductase activity +namespace: molecular_function +def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0015049 +name: methane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25, PMID:10896210] +synonym: "methane hydroxylase activity" RELATED [EC:1.14.13.25] +synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.13.25] +xref: EC:1.14.13.25 +xref: KEGG_REACTION:R01142 +xref: KEGG_REACTION:R01143 +xref: MetaCyc:METHANE-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0007 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0015050 +name: methane monooxygenase complex +namespace: cellular_component +def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0015051 +name: obsolete X-opioid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420] +comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. +synonym: "X-opioid receptor activity" EXACT [] +is_obsolete: true +consider: GO:0001626 + +[Term] +id: GO:0015052 +name: beta3-adrenergic receptor activity +namespace: molecular_function +def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] +synonym: "beta3 adrenoceptor" EXACT [] +is_a: GO:0004939 ! beta-adrenergic receptor activity + +[Term] +id: GO:0015053 +name: obsolete opsin +namespace: molecular_function +def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "opsin" EXACT [] +is_obsolete: true +consider: GO:0007602 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015054 +name: gastrin receptor activity +namespace: molecular_function +def: "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity." [GOC:ai, GOC:signaling] +synonym: "cholecystokinin-B receptor activity" RELATED [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0015055 +name: secretin receptor activity +namespace: molecular_function +def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0015056 +name: corticotrophin-releasing factor receptor activity +namespace: molecular_function +def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0015057 +name: thrombin-activated receptor activity +namespace: molecular_function +alt_id: GO:0010655 +def: "A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it." [GOC:ai, GOC:pg, PMID:20423334] +synonym: "thrombin receptor activity" EXACT [] +synonym: "thrombin receptor activity, G-protein coupled" EXACT [] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0015058 +name: obsolete epidermal growth factor-like module containing hormone receptor activity +namespace: molecular_function +alt_id: GO:0016523 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. +synonym: "EGF-like module containing hormone receptor activity" EXACT [] +synonym: "Egr1 hormone receptor" EXACT [] +synonym: "epidermal growth factor-like module containing hormone receptor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015059 +name: obsolete blue-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "blue-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015060 +name: obsolete green-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "green-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015061 +name: obsolete red-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "red-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009585 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015062 +name: obsolete violet-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "violet-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015063 +name: obsolete long-wave-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "long-wave-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015064 +name: obsolete UV-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "UV-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007604 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0015066 +name: alpha-amylase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0015067 +name: amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] +synonym: "transamidinase activity" EXACT [] +xref: EC:2.1.4.- +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0015068 +name: glycine amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [RHEA:13201] +synonym: "arginine-glycine amidinotransferase activity" RELATED [EC:2.1.4.1] +synonym: "arginine-glycine transamidinase activity" RELATED [EC:2.1.4.1] +synonym: "glycine transamidinase activity" RELATED [EC:2.1.4.1] +synonym: "L-arginine:glycine amidinotransferase activity" RELATED [EC:2.1.4.1] +xref: EC:2.1.4.1 +xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN +xref: Reactome:R-HSA-71275 "arginine + glycine => ornithine + guanidoacetate" +xref: RHEA:13201 +is_a: GO:0015067 ! amidinotransferase activity + +[Term] +id: GO:0015069 +name: scyllo-inosamine-4-phosphate amidinotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [RHEA:13265] +synonym: "inosamine-P amidinotransferase activity" RELATED [EC:2.1.4.2] +synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] +synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" RELATED [EC:2.1.4.2] +synonym: "L-arginine:inosamine phosphate amidinotransferase activity" RELATED [EC:2.1.4.2] +synonym: "L-arginine:inosamine-P-amidinotransferase activity" RELATED [EC:2.1.4.2] +xref: EC:2.1.4.2 +xref: KEGG_REACTION:R03477 +xref: MetaCyc:2.1.4.2-RXN +xref: RHEA:13265 +is_a: GO:0015067 ! amidinotransferase activity + +[Term] +id: GO:0015070 +name: obsolete toxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl] +comment: This term was made obsolete because it represents a classification of molecules and not a molecular function. +synonym: "toxin activity" EXACT [] +is_obsolete: true +consider: GO:0090729 + +[Term] +id: GO:0015072 +name: obsolete phosphatidylinositol 3-kinase, class I, catalyst activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" EXACT [] +is_obsolete: true +consider: GO:0016303 +consider: GO:0035005 +consider: GO:0046934 + +[Term] +id: GO:0015073 +name: obsolete phosphatidylinositol 3-kinase, class I, regulator activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] +comment: This term was made obsolete because it refers to a class of gene products. +synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046935 + +[Term] +id: GO:0015074 +name: DNA integration +namespace: biological_process +def: "The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0015075 +name: ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] +synonym: "ion transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015076 +name: obsolete heavy metal ion transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "heavy metal ion transporter activity" EXACT [] +is_obsolete: true +consider: GO:0046873 + +[Term] +id: GO:0015078 +name: proton transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] +synonym: "hydrogen ion transmembrane transporter activity" EXACT [] +synonym: "proton transporter activity" EXACT [] +xref: Reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase" +xref: Reactome:R-HSA-164834 "Enzyme-bound ATP is released" +xref: Reactome:R-HSA-170026 "Protons are translocated from the intermembrane space to the matrix" +xref: Reactome:R-HSA-74723 "Endosome acidification" +xref: Reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015079 +name: potassium ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015388 +alt_id: GO:0022817 +def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] +synonym: "potassium transporter activity" EXACT [] +synonym: "potassium uptake permease activity" RELATED [] +synonym: "potassium uptake transmembrane transporter activity" RELATED [] +xref: RHEA:29463 +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015080 +name: silver ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] +synonym: "silver transporter activity" EXACT [] +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015081 +name: sodium ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0022816 +def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] +synonym: "sodium transporter activity" EXACT [] +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015083 +name: aluminum ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015084 +def: "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "aluminium ion transporter activity" EXACT [] +synonym: "aluminium resistance permease activity" EXACT [] +synonym: "aluminum resistance permease activity" EXACT [] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0015085 +name: calcium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] +xref: Reactome:R-HSA-2534359 "CatSper Channel Mediated Calcium Transport" +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015086 +name: cadmium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf] +synonym: "zinc, cadmium uptake permease activity" RELATED [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015087 +name: cobalt ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:dgf] +synonym: "cobalt, zinc uptake permease activity" RELATED [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] +xref: RHEA:28578 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015089 +name: high-affinity copper ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1] +synonym: "high affinity copper ion transmembrane transporter activity" EXACT [] +synonym: "high affinity copper transporter activity" EXACT [] +is_a: GO:0005375 ! copper ion transmembrane transporter activity + +[Term] +id: GO:0015090 +name: low-affinity ferric iron ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1] +synonym: "low affinity iron ion transmembrane transporter activity" EXACT [] +synonym: "low affinity iron transporter activity" EXACT [] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity + +[Term] +id: GO:0015091 +name: ferric iron transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732] +comment: Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity. +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015092 +name: high-affinity ferric iron transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:ai, PMID:1447137] +synonym: "high affinity ferric uptake transmembrane transporter activity" RELATED [] +is_a: GO:0015091 ! ferric iron transmembrane transporter activity + +[Term] +id: GO:0015093 +name: ferrous iron transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015639 +def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732] +synonym: "ferrous iron uptake transmembrane transporter activity" RELATED [] +xref: Reactome:R-HSA-1362417 "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix" +xref: Reactome:R-HSA-442368 "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region" +xref: Reactome:R-HSA-5655760 "Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol" +xref: RHEA:28486 +is_a: GO:0005381 ! iron ion transmembrane transporter activity + +[Term] +id: GO:0015094 +name: lead ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0015095 +name: magnesium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf] +xref: Reactome:R-HSA-442661 "SLC41A1,2 transport Mg2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5336453 "NIPAs transport Mg2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5336454 "MMGT1 transports Mg2+ from cytosol to Golgi lumen" +xref: Reactome:R-HSA-5336466 "MRS2 transports Mg2+ from cytosol to mitochondrial matrix" +xref: Reactome:R-HSA-5339528 "TUSC3 transports Mg2+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5339538 "MAGT1 transports Mg2+ from extracellular region to cytosol" +xref: RHEA:29827 +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0015096 +name: obsolete manganese resistance permease activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition. +synonym: "manganese resistance permease activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015097 +name: mercury ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] +xref: RHEA:32815 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015098 +name: molybdate ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732] +synonym: "molybdate transporter activity" EXACT [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015099 +name: nickel cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other." [GOC:ai] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] +xref: RHEA:29831 +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015100 +name: vanadium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0015101 +name: organic cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" +xref: Reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" +xref: Reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" +xref: Reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" +xref: Reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" +xref: Reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" +xref: Reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" +is_a: GO:0008324 ! cation transmembrane transporter activity + +[Term] +id: GO:0015103 +name: inorganic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0015104 +name: antimonite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of antimonite from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015105 +name: arsenite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of arsenite from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015106 +name: bicarbonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] +xref: Reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" +xref: RHEA:28695 +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015107 +name: chlorate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other." [GOC:curators] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015108 +name: chloride transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0008555 +def: "Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] +synonym: "ATP-dependent chloride transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled chloride transmembrane transporter activity" NARROW [] +synonym: "chloride ABC transporter" NARROW [] +synonym: "chloride ion transmembrane transporter activity" EXACT [GOC:pr] +synonym: "chloride transporting ATPase activity" NARROW [] +synonym: "chloride-transporting ATPase activity" NARROW [] +xref: MetaCyc:3.6.3.11-RXN +xref: Reactome:R-HSA-5678822 "Defective CFTR does not transport Cl- from cytosol to extracellular region" +xref: Reactome:R-HSA-5678863 "CFTR transports Cl- from cytosol to extracellular region" +xref: Reactome:R-HSA-5678992 "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region" +xref: RHEA:29823 +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015109 +name: chromate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] +xref: RHEA:32819 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015110 +name: cyanate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:0015111 +name: iodide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] +xref: Reactome:R-HSA-209910 "Iodide is taken up by thyroid epithelial cells" +xref: Reactome:R-HSA-5627802 "SLC26A4 transports I- from cytosol to extracellular region" +xref: Reactome:R-HSA-5627870 "SLC26A4 does not transport I- from cytosol to extracellular region" +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015112 +name: nitrate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai, RHEA:34923] +synonym: "nitrite/nitrate porter activity" RELATED [] +xref: RHEA:34923 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015113 +name: nitrite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai] +synonym: "nitrite/nitrate porter activity" RELATED [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015114 +name: phosphate ion transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901677 +def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] +synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw] +xref: RHEA:32823 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015115 +name: silicate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015116 +name: sulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] +synonym: "sulfate permease activity" RELATED [] +synonym: "sulphate transporter activity" EXACT [] +xref: Reactome:R-HSA-3560789 "Defective SLC26A2 does not cotransport extracellular SO4(2-), H+ to cytosol" +xref: Reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" +xref: RHEA:34983 +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015117 +name: thiosulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai] +synonym: "thiosulfate permease activity" RELATED [] +synonym: "thiosulphate transporter activity" EXACT [] +xref: RHEA:32807 +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015119 +name: hexose phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015120 +name: phosphoglycerate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0015121 +name: phosphoenolpyruvate:phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl] +synonym: "phosphoenolpyruvate/phosphate translocator" EXACT [] +synonym: "PPT" BROAD [PMID:10488230] +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity +is_a: GO:0089721 ! phosphoenolpyruvate transmembrane transporter activity + +[Term] +id: GO:0015123 +name: acetate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015124 +name: allantoate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0015125 +name: bile acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] +xref: Reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" +xref: Reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" +xref: Reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" +xref: Reactome:R-HSA-5661184 "Defective SLCO1B1 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-5661198 "Defective SLCO1B3 does not transport BIL from extracellular region (blood) to cytosol (hepatocyte)" +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015126 +name: canalicular bile acid transmembrane transporter activity +namespace: molecular_function +def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] +is_a: GO:0015125 ! bile acid transmembrane transporter activity + +[Term] +id: GO:0015127 +name: bilirubin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] +xref: Reactome:R-HSA-5679031 "Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region" +xref: Reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" +xref: Reactome:R-HSA-9661417 "ABCG2 tetramer transports BMG,BDG from cytosol to extracellular region" +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015128 +name: gluconate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732] +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0015129 +name: lactate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] +xref: Reactome:R-HSA-373867 "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-373875 "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region" +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015130 +name: mevalonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015131 +name: oxaloacetate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity + +[Term] +id: GO:0015132 +name: prostaglandin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] +synonym: "prostaglandin/thromboxane transporter activity" BROAD [] +xref: Reactome:R-HSA-5661188 "Defective SLCO2A1 does not transport PGT substrates from extracellular region to cytosol" +xref: Reactome:R-HSA-879528 "SLCO2A1 transports PGT substrates from extracellular region to cytosol" +is_a: GO:0071714 ! icosanoid transmembrane transporter activity + +[Term] +id: GO:0015133 +name: uronic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015134 +name: hexuronate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015163 +def: "Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "hexuronide transmembrane transporter activity" EXACT [] +is_a: GO:0015133 ! uronic acid transmembrane transporter activity + +[Term] +id: GO:0015135 +name: glucuronate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015136 +name: sialic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sialic acid from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015137 +name: citrate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai] +synonym: "tricarboxylate transport protein" RELATED [TC:2.A.29.7.2] +xref: Reactome:R-HSA-433104 "NACT co-transports trivalent citrate and a sodium ion" +xref: TC:2.A.29.7.2 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015138 +name: fumarate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity + +[Term] +id: GO:0015139 +name: alpha-ketoglutarate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] +synonym: "2-oxoglutarate transporter activity" EXACT [] +xref: Reactome:R-HSA-372480 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]" +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015140 +name: malate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity + +[Term] +id: GO:0015141 +name: succinate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732] +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity + +[Term] +id: GO:0015142 +name: tricarboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] +synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] +xref: Reactome:R-HSA-372449 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]" +xref: Reactome:R-HSA-75849 "Transport of Citrate from Mitochondrial Matrix to cytosol" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015143 +name: urate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] +synonym: "uric acid transmembrane transporter activity" EXACT [] +xref: Reactome:R-HSA-2872497 "SLC17A3-2 transports cytosolic urate to extracellular region" +xref: Reactome:R-HSA-561253 "SLC22A12 exchanges extracellular urate for cytosolic LACT" +xref: Reactome:R-HSA-5625210 "Defective SLC22A12 does not exchange extracellular urate for cytosolic LACT" +is_a: GO:1901702 ! salt transmembrane transporter activity + +[Term] +id: GO:0015144 +name: carbohydrate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901476 +def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +synonym: "carbohydrate transporter activity" RELATED [] +synonym: "sugar transporter" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015145 +name: monosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0051119 ! sugar transmembrane transporter activity + +[Term] +id: GO:0015146 +name: pentose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015147 +name: L-arabinose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0015148 +name: D-xylose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0015149 +name: hexose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" +xref: Reactome:R-HSA-5638222 "Defective SLC2A2 does not transport Fru, Gal, Glc from cytosol to extracellular region" +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity + +[Term] +id: GO:0015150 +name: fucose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015151 +name: alpha-glucoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0042947 ! glucoside transmembrane transporter activity + +[Term] +id: GO:0015152 +name: glucose-6-phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015153 +name: rhamnose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0033297 +def: "Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, RHEA:34995] +synonym: "ATP-dependent rhamnose transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled rhamnose transmembrane transporter activity" NARROW [] +synonym: "rhamnose-transporting ATPase activity" NARROW [] +xref: RHEA:34995 +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015154 +name: disaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of disaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity + +[Term] +id: GO:0015155 +name: lactose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019189 +def: "Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "lactose permease activity" EXACT [] +synonym: "lactose/glucose efflux transporter activity" NARROW [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015156 +name: melibiose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015157 +name: oligosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oligosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +synonym: "endosomal oligosaccharide transporter" NARROW [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0015158 +name: raffinose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "raffinose permease" RELATED [] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity + +[Term] +id: GO:0015159 +name: polysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity + +[Term] +id: GO:0015160 +name: beta-glucan transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0015161 +name: lipid III floppase activity +namespace: molecular_function +def: "Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, PMID:12621029, PMID:16816184] +synonym: "capsular polysaccharide transmembrane transporter activity" RELATED [] +synonym: "capsule polysaccharide transporter activity" BROAD [] +synonym: "undecaprenol-pyrophosphate O-antigen flippase activity" EXACT [TC:2.A.66.2.3] +xref: TC:2.A.66.2.12 +xref: TC:2.A.66.2.3 +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0015164 +name: glucuronoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "glucuronide transporter activity" EXACT [] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015165 +name: pyrimidine nucleotide-sugar transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0015166 +name: polyol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732] +synonym: "sugar/polyol channel activity" NARROW [] +xref: Reactome:R-HSA-429571 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6" +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015167 +name: arabitol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] +synonym: "arabinitol transporter activity" EXACT [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015168 +name: glycerol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015169 +name: glycerol-3-phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015170 +name: propanediol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015171 +name: amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015359 +def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "amino acid permease activity" EXACT [] +synonym: "amino acid transporter activity" BROAD [] +synonym: "amino acid/choline transmembrane transporter activity" NARROW [] +synonym: "general amino acid permease activity" RELATED [] +synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] +xref: Reactome:R-HSA-210439 "glutamate uptake by astrocytes" +xref: Reactome:R-HSA-212642 "L-Glutamine transport into neurons" +xref: Reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" +xref: Reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" +xref: Reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" +xref: Reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" +xref: Reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" +xref: Reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" +xref: Reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" +xref: Reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" +xref: Reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" +xref: Reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" +xref: Reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" +xref: Reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" +xref: Reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" +xref: Reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" +xref: Reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" +xref: Reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" +xref: Reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" +xref: Reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" +xref: Reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" +xref: Reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" +xref: Reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" +xref: Reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" +xref: Reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" +xref: Reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" +xref: Reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" +xref: Reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5653850 "Defective SLC36A2 does not cotransport Gly, L-Pro with H+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5655702 "Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5659674 "Variant SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5659734 "Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5659755 "Defective SLC6A18 does not transport Gly from extracellular region to cytosol" +xref: Reactome:R-HSA-5660694 "Variant SLC6A20 does not cotransport L-Pro, Na+ from extracellulare region to cytosol" +xref: Reactome:R-HSA-5660890 "Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu" +xref: Reactome:R-HSA-5660910 "Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane" +xref: Reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" +xref: Reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015172 +name: acidic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "acidic amino acid transporter activity" BROAD [] +xref: Reactome:R-HSA-372448 "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp" +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015173 +name: aromatic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "aromatic amino acid transporter activity" BROAD [] +synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015174 +name: basic amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005286 +alt_id: GO:0015326 +def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "basic amino acid permease activity" EXACT [] +synonym: "basic amino acid transporter activity" BROAD [] +synonym: "cationic amino acid transmembrane transporter activity" RELATED [] +xref: Reactome:R-HSA-8932851 "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-8959781 "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015175 +name: neutral amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "neutral amino acid transporter activity" BROAD [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015176 +name: obsolete holin +namespace: molecular_function +def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "holin" EXACT [] +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015179 +name: L-amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-amino acid transporter activity" BROAD [] +xref: Reactome:R-HSA-212614 "Glutamine transport from astrocytes" +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015180 +name: L-alanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "L-alanine transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0022858 ! alanine transmembrane transporter activity + +[Term] +id: GO:0015182 +name: L-asparagine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "asparagine/glutamine permease activity" NARROW [] +synonym: "L-asparagine transporter activity" BROAD [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0015183 +name: L-aspartate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "glutamate/aspartate porter activity" NARROW [] +synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] +synonym: "L-aspartate transporter activity" BROAD [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity + +[Term] +id: GO:0015184 +name: L-cystine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "cystine/diaminopimelate porter activity" NARROW [] +synonym: "L-cystine transporter activity" BROAD [] +xref: Reactome:R-HSA-5340130 "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol" +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015185 +name: gamma-aminobutyric acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "4-aminobutanoate transporter activity" EXACT [] +synonym: "4-aminobutyrate transporter activity" EXACT [] +synonym: "betaine/GABA:sodium symporter activity" NARROW [] +synonym: "GABA transporter activity" EXACT [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015186 +name: L-glutamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "asparagine/glutamine permease activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015187 +name: glycine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "glycine transporter activity" BROAD [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015188 +name: L-isoleucine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "isoleucine/valine:sodium symporter activity" NARROW [] +synonym: "L-isoleucine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity + +[Term] +id: GO:0015189 +name: L-lysine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005293 +def: "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-lysine permease" RELATED [] +synonym: "lysine permease activity" RELATED [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015190 +name: L-leucine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-leucine transporter activity" BROAD [] +synonym: "leucine/isoleucine/valine porter activity" NARROW [] +synonym: "leucine/valine/isoleucine permease activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity + +[Term] +id: GO:0015191 +name: L-methionine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-methionine transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0043865 ! methionine transmembrane transporter activity + +[Term] +id: GO:0015192 +name: L-phenylalanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-phenylalanine permease activity" EXACT [] +synonym: "L-phenylalanine transporter activity" BROAD [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015193 +name: L-proline transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005296 +def: "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "L-proline permease activity" RELATED [] +synonym: "L-proline transporter activity" BROAD [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +xref: Reactome:R-HSA-8870354 "SLC36A4 transports extracellular L-Pro to the cytosol" +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015194 +name: L-serine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015511 +alt_id: GO:1905361 +def: "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-serine permease activity" RELATED [] +synonym: "L-serine transporter activity" BROAD [] +synonym: "serine transporter activity" BROAD [] +synonym: "threonine/serine:sodium symporter activity" RELATED [] +xref: Reactome:R-HSA-8932980 "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0022889 ! serine transmembrane transporter activity + +[Term] +id: GO:0015195 +name: L-threonine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015512 +def: "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-threonine permease activity" RELATED [] +synonym: "L-threonine transporter activity" BROAD [] +synonym: "threonine/serine:sodium symporter activity" RELATED [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015196 +name: L-tryptophan transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005299 +def: "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-tryptophan permease activity" EXACT [] +synonym: "L-tryptophan transporter activity" BROAD [] +synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] +xref: Reactome:R-HSA-8870352 "SLC36A4 transports L-Trp from extracellular region to cytosol" +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015199 +name: amino-acid betaine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid." [GOC:ai] +synonym: "betaine transmembrane transporter activity" EXACT [] +synonym: "betaine/GABA:sodium symporter activity" NARROW [] +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015200 +name: methylammonium transmembrane transporter activity +namespace: molecular_function +def: "Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0008324 ! cation transmembrane transporter activity + +[Term] +id: GO:0015203 +name: polyamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other." [GOC:ai] +synonym: "amine/amide/polyamine channel activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015204 +name: urea transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015287 +def: "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732] +synonym: "urea transporter activity" BROAD [] +xref: Reactome:R-HSA-444126 "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively" +xref: RHEA:32799 +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0015205 +name: nucleobase transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015392 +def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015207 +name: adenine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] +xref: Reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane" +xref: Reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane" +xref: RHEA:34999 +is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity + +[Term] +id: GO:0015208 +name: guanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] +is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity + +[Term] +id: GO:0015209 +name: cytosine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] +is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity + +[Term] +id: GO:0015210 +name: uracil transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] +synonym: "uracil/uridine permease activity" RELATED [] +is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity + +[Term] +id: GO:0015211 +name: purine nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0015212 +name: cytidine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] +is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015213 +name: uridine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] +synonym: "uracil/uridine permease activity" NARROW [] +is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015214 +name: pyrimidine nucleoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0015215 +name: nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732] +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity + +[Term] +id: GO:0015216 +name: purine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0015217 +name: ADP transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015218 +name: pyrimidine nucleotide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0015219 +name: obsolete protein-DNA complex transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai] +comment: This term was obsoleted because there is no experimental evidence that this function exists. +synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0015220 +name: choline transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005306 +def: "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] +synonym: "amino acid/choline transmembrane transporter activity" NARROW [] +synonym: "choline permease activity" EXACT [] +xref: Reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol" +xref: Reactome:R-HSA-5658483 "Defective SLC5A7 does not cotransport Cho, Cl-, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix" +is_a: GO:0015101 ! organic cation transmembrane transporter activity + +[Term] +id: GO:0015221 +name: lipopolysaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "LPS transmembrane transporter activity" EXACT [] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015223 +name: obsolete vitamin or cofactor transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "vitamin or cofactor transporter activity" EXACT [] +synonym: "vitamin/cofactor transporter activity" EXACT [] +is_obsolete: true +consider: GO:0090482 + +[Term] +id: GO:0015224 +name: biopterin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732] +synonym: "biopterin transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015225 +name: biotin transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901603 +def: "Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] +synonym: "biotin transporter activity" RELATED [] +synonym: "vitamin B7 transporter activity" RELATED [] +synonym: "vitamin H transporter activity" RELATED [] +xref: RHEA:28458 +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015226 +name: carnitine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] +synonym: "vitamin Bt transporter activity" EXACT [] +xref: Reactome:R-HSA-164967 "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space" +xref: Reactome:R-HSA-165026 "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol" +xref: Reactome:R-HSA-549297 "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5625674 "Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol" +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015227 +name: acyl carnitine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] +synonym: "acylcarnitine transporter activity" BROAD [] +xref: Reactome:R-HSA-200424 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane" +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity + +[Term] +id: GO:0015228 +name: coenzyme A transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] +synonym: "coenzyme A transporter activity" BROAD [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity + +[Term] +id: GO:0015229 +name: L-ascorbic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [ISBN:0198506732] +synonym: "L-ascorbate transporter activity" EXACT [] +synonym: "vitamin C transporter activity" EXACT [] +xref: Reactome:R-HSA-198870 "SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0015230 +name: FAD transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005472 +def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] +synonym: "FAD carrier activity" RELATED [] +synonym: "FAD transporter activity" BROAD [] +synonym: "flavin adenine dinucleotide carrier activity" RELATED [] +synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "flavin-adenine dinucleotide carrier activity" RELATED [] +synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0015231 +name: 5-formyltetrahydrofolate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other." [GOC:ai] +synonym: "5-formyltetrahydrofolate transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015232 +name: heme transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of heme from one side of a membrane to the other." [PMID:29549126] +synonym: "haem transporter activity" EXACT [] +synonym: "heme transporter activity" BROAD [] +xref: Reactome:R-HSA-917870 "SLC46A1 transports FeHM, heme from extracellular region to cytosol" +xref: Reactome:R-HSA-917892 "FLVCR1-1 transports heme from cytosol to extracellular region" +xref: Reactome:R-HSA-9661408 "FLVCR1-2 transports heme from mitochondrial matrix to cytosol" +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015233 +name: pantothenate transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] +synonym: "pantothenate transporter activity" BROAD [GOC:mah] +synonym: "vitamin B5 transmembrane transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0015234 +name: thiamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015402 +alt_id: GO:0015403 +def: "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "thiamin permease activity" EXACT [] +synonym: "thiamin transmembrane transporter activity" EXACT [] +synonym: "thiamin uptake transporter activity" RELATED [] +synonym: "thiamine permease activity" EXACT [] +synonym: "thiamine uptake transmembrane transporter activity" RELATED [] +synonym: "vitamin B1 transporter activity" EXACT [] +xref: Reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol" +xref: RHEA:34919 +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015240 +name: amiloride transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732] +synonym: "amiloride transporter activity" RELATED [] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0015243 +name: cycloheximide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] +synonym: "cycloheximide transporter activity" RELATED [] +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0015244 +name: fluconazole transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] +synonym: "fluconazole transporter activity" RELATED [] +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:0015245 +name: fatty acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015246 +def: "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] +synonym: "fatty acid transporter activity" RELATED [] +synonym: "fatty acyl transporter activity" EXACT [] +synonym: "fatty-acyl group transporter activity" BROAD [] +synonym: "peroxisomal fatty acyl transporter" NARROW [] +xref: Reactome:R-HSA-5627891 "Defective SLC27A4 does not transport LCFAs from extracellular region to cytosol" +xref: Reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol" +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0015247 +name: aminophospholipid flippase activity +namespace: molecular_function +def: "Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:pg] +synonym: "aminophospholipid transmembrane transporter activity" RELATED [] +synonym: "aminophospholipid transporter activity" RELATED [] +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0140327 ! flippase activity + +[Term] +id: GO:0015248 +name: sterol transporter activity +namespace: molecular_function +def: "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] +xref: Reactome:R-HSA-265783 "ABCG5:ABCG8 transports sterols from cytosol to extracellular region" +xref: Reactome:R-HSA-5250531 "ARV1 transports CHOL from ER membrane to plasma membrane" +xref: Reactome:R-HSA-5679101 "Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region" +xref: Reactome:R-HSA-5679145 "Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region" +xref: Reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane" +xref: Reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane" +xref: RHEA:39747 +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0015250 +name: water channel activity +namespace: molecular_function +def: "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +synonym: "aquaporin" NARROW [] +xref: Reactome:R-HSA-432010 "Aquaporin-1 passively transports water into cell" +xref: Reactome:R-HSA-432054 "Aquaporin-1 passively transports water out of cell" +xref: Reactome:R-HSA-432065 "p-S256-Aquaporin-2 passively transports water into cell" +xref: Reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell" +xref: Reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell" +xref: Reactome:R-HSA-507868 "Aquaporins passively transport water into cells" +xref: Reactome:R-HSA-507870 "Aquaporins passively transport water out of cells" +xref: RHEA:29667 +is_a: GO:0005372 ! water transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015252 +name: proton channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] +synonym: "hydrogen ion channel activity" EXACT [] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0015078 ! proton transmembrane transporter activity + +[Term] +id: GO:0015253 +name: obsolete sugar/polyol channel activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "sugar/polyol channel activity" EXACT [] +is_obsolete: true +consider: GO:0015166 +consider: GO:0051119 + +[Term] +id: GO:0015254 +name: glycerol channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell" +xref: Reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell" +xref: Reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells" +xref: Reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells" +xref: RHEA:29675 +is_a: GO:0015168 ! glycerol transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015255 +name: propanediol channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +is_a: GO:0015170 ! propanediol transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015256 +name: obsolete monocarboxylate channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "monocarboxylate channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015257 +name: obsolete organic anion channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "organic anion channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015258 +name: obsolete gluconate channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "gluconate channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015259 +name: obsolete glutamate channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "glutamate channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015260 +name: obsolete isethionate channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "isethionate channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015261 +name: obsolete lactate channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "lactate channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015262 +name: obsolete taurine channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. +synonym: "taurine channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015263 +name: obsolete amine/amide/polyamine channel activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents three molecular functions. +synonym: "amine/amide/polyamine channel activity" EXACT [] +is_obsolete: true +consider: GO:0005275 +consider: GO:0015203 +consider: GO:0042887 + +[Term] +id: GO:0015264 +name: methylammonium channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport, GOC:pr] +is_a: GO:0015200 ! methylammonium transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015265 +name: urea channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] +xref: Reactome:R-HSA-507873 "Aquaporins passively transport urea out of cells" +xref: Reactome:R-HSA-507875 "Aquaporins passively transport urea into cells" +is_a: GO:0015204 ! urea transmembrane transporter activity +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0015267 +name: channel activity +namespace: molecular_function +alt_id: GO:0015249 +alt_id: GO:0015268 +alt_id: GO:0022838 +def: "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729] +synonym: "alpha-type channel activity" RELATED [] +synonym: "channel-forming toxin activity" RELATED [] +synonym: "channel/pore class transporter activity" EXACT [] +synonym: "nonselective channel activity" EXACT [] +synonym: "pore activity" BROAD [] +synonym: "pore class transporter activity" RELATED [] +synonym: "substrate-specific channel activity" RELATED [] +xref: Reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol" +xref: Reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix" +xref: TC:1 +is_a: GO:0022803 ! passive transmembrane transporter activity + +[Term] +id: GO:0015269 +name: calcium-activated potassium channel activity +namespace: molecular_function +def: "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] +is_a: GO:0005227 ! calcium activated cation channel activity +is_a: GO:0005267 ! potassium channel activity + +[Term] +id: GO:0015271 +name: outward rectifier potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah] +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0015272 +name: ATP-activated inward rectifier potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] +xref: Reactome:R-HSA-5683209 "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)." +is_a: GO:0005242 ! inward rectifier potassium channel activity + +[Term] +id: GO:0015274 +name: organellar voltage-gated chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "organellar voltage gated chloride channel activity" EXACT [] +synonym: "organellar voltage-dependent chloride channel activity" EXACT [] +is_a: GO:0005247 ! voltage-gated chloride channel activity + +[Term] +id: GO:0015275 +name: stretch-activated, cation-selective, calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0140135 ! mechanosensitive cation channel activity + +[Term] +id: GO:0015276 +name: ligand-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart] +xref: Reactome:R-HSA-451310 "Activation of Edited Kainate receptors" +xref: Reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors" +xref: Reactome:R-HSA-622325 "Activation of highly sodium permeable postsynaptic nicotinic acetylcholine receptors" +xref: Reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors" +xref: Reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors" +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022834 ! ligand-gated channel activity + +[Term] +id: GO:0015277 +name: kainate selective glutamate receptor activity +namespace: molecular_function +def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. +is_a: GO:0004970 ! ionotropic glutamate receptor activity +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0005272 ! sodium channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0015278 +name: calcium-release channel activity +namespace: molecular_function +alt_id: GO:0005218 +def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] +synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278] +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0099604 ! ligand-gated calcium channel activity + +[Term] +id: GO:0015279 +name: store-operated calcium channel activity +namespace: molecular_function +def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710] +xref: Reactome:R-HSA-434798 "CRAC translocates calcium from the extracellular region to the cytosol" +is_a: GO:0005262 ! calcium channel activity + +[Term] +id: GO:0015280 +name: ligand-gated sodium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] +synonym: "acid-sensing ion channel activity" NARROW [GOC:fj] +synonym: "amiloride-sensitive sodium channel activity" NARROW [GOC:fj] +synonym: "ASIC activity" NARROW [GOC:fj] +synonym: "epithelial sodium channel" NARROW [GOC:fj] +xref: Reactome:R-HSA-2672334 "SCNN channels transport extracellular Na+ to cytosol" +is_a: GO:0005272 ! sodium channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0015282 +name: obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it describes a gene product rather than a function. +synonym: "NADPH oxidase-associated cytochrome b558 hydrogen channel activity" EXACT [] +synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015283 +name: obsolete apoptogenic cytochrome c release channel activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it represents a gene product. +synonym: "apoptogenic cytochrome c release channel activity" EXACT [] +synonym: "Bcl-2" NARROW [] +is_obsolete: true + +[Term] +id: GO:0015284 +name: fructose uniporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0015288 +name: porin activity +namespace: molecular_function +def: "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] +synonym: "outer membrane exporter porin" NARROW [] +synonym: "porin" EXACT [] +xref: Wikipedia:Porin_(protein) +is_a: GO:0022829 ! wide pore channel activity + +[Term] +id: GO:0015289 +name: obsolete pore-forming toxin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "pore-forming toxin activity" EXACT [] +is_obsolete: true +consider: GO:0005198 +consider: GO:0046930 +consider: GO:0046931 +consider: GO:0090729 + +[Term] +id: GO:0015291 +name: secondary active transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015290 +alt_id: GO:0015353 +alt_id: GO:0015404 +alt_id: GO:0015570 +def: "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820] +synonym: "active transporter" BROAD [] +synonym: "coupled carrier" EXACT [] +synonym: "electrochemical potential-driven transporter activity" EXACT [] +synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] +synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] +synonym: "heavy metal ion porter activity" NARROW [] +synonym: "ion-gradient-driven energizer activity" NARROW [] +synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] +synonym: "nitrite/nitrate porter activity" NARROW [] +synonym: "porter activity" EXACT [] +synonym: "porters" EXACT [] +synonym: "secondary carrier-type facilitators" EXACT [] +xref: Reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix" +xref: TC:2.A +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0015292 +name: uniporter activity +namespace: molecular_function +def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +synonym: "facilitated diffusion carrier" EXACT [] +synonym: "single-species transporter activity" EXACT [] +synonym: "uniport" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015293 +name: symporter activity +namespace: molecular_function +def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +synonym: "cotransporter activity" BROAD [] +synonym: "porter activity" BROAD [] +synonym: "symport" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015294 +name: solute:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] +is_a: GO:0015293 ! symporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0015295 +name: solute:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] +synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] +synonym: "high affinity metal ion uptake transporter activity" NARROW [] +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +synonym: "low affinity metal ion uptake transporter activity" NARROW [] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +synonym: "solute:hydrogen symporter activity" EXACT [] +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015296 +name: anion:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015297 +name: antiporter activity +namespace: molecular_function +alt_id: GO:0015300 +alt_id: GO:0099516 +def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] +synonym: "antiport" RELATED [] +synonym: "countertransporter activity" EXACT [] +synonym: "exchange transporter activity" EXACT [] +synonym: "exchanger" BROAD [] +synonym: "ion antiporter activity" NARROW [] +synonym: "porter" BROAD [] +synonym: "solute:solute antiporter activity" EXACT [] +synonym: "solute:solute exchange" RELATED [] +xref: Reactome:R-HSA-2730692 "CLCN4/5/6 exchange Cl- for H+" +xref: Reactome:R-HSA-2730959 "CLCN7:OSTM1 exchanges Cl- for H+" +xref: Reactome:R-HSA-2731002 "CLCN3 exchanges Cl- for H+" +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015298 +name: solute:cation antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015299 +name: solute:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] +synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] +synonym: "solute:hydrogen antiporter activity" EXACT [] +xref: Reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" +xref: Reactome:R-HSA-5625574 "Defective SLC22A18 does not exchange extracellular organic cations for cytosolic H+" +xref: Reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" +is_a: GO:0015078 ! proton transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0015301 +name: anion:anion antiporter activity +namespace: molecular_function +alt_id: GO:0015380 +alt_id: GO:0015384 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] +synonym: "anion exchanger activity" EXACT [] +synonym: "bicarbonate:chloride antiporter" NARROW [] +xref: Reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids" +is_a: GO:0140323 ! solute:anion antiporter activity + +[Term] +id: GO:0015303 +name: obsolete galactose, glucose uniporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "galactose, glucose uniporter activity" EXACT [] +is_obsolete: true +consider: GO:0015304 +consider: GO:0050782 + +[Term] +id: GO:0015304 +name: glucose uniporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] +synonym: "galactose, glucose uniporter activity" NARROW [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0015305 +name: obsolete lactose, galactose:proton symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "lactose, galactose:hydrogen symporter activity" EXACT [] +synonym: "lactose, galactose:proton symporter activity" EXACT [] +synonym: "lactose,galactose:proton symporter activity" EXACT [] +is_obsolete: true +consider: GO:0015517 +consider: GO:0015528 + +[Term] +id: GO:0015306 +name: sialate:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] +synonym: "cation/sialate symporter activity" EXACT [] +synonym: "cation:sialate symporter activity" EXACT [] +synonym: "sialate transporter activity" BROAD [] +synonym: "sialate/cation symporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015136 ! sialic acid transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0015307 +name: obsolete drug:proton antiporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] +comment: This term was obsoleted because it is not possible to state that every case of transmembrane transport for a specific chemical constitutes a drug transport. +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +synonym: "drug:hydrogen antiporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015308 +name: amiloride:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] +synonym: "amiloride:hydrogen antiporter activity" EXACT [] +is_a: GO:0015240 ! amiloride transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0015309 +name: cycloheximide:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] +synonym: "cycloheximide:hydrogen antiporter activity" EXACT [] +is_a: GO:0015243 ! cycloheximide transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0015310 +name: benomyl:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] +synonym: "benomyl:hydrogen antiporter activity" EXACT [] +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:1901479 ! benomyl transmembrane transporter activity + +[Term] +id: GO:0015311 +name: monoamine:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] +synonym: "monoamine:hydrogen antiporter activity" EXACT [] +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0015312 +name: polyamine:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] +synonym: "polyamine:hydrogen antiporter activity" EXACT [] +is_a: GO:0015203 ! polyamine transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0015313 +name: fluconazole:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] +synonym: "fluconazole:hydrogen antiporter activity" EXACT [] +is_a: GO:0015244 ! fluconazole transmembrane transporter activity +is_a: GO:0045119 ! azole:proton antiporter activity + +[Term] +id: GO:0015314 +name: aminotriazole:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] +synonym: "aminotriazole:hydrogen antiporter activity" EXACT [] +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0045119 ! azole:proton antiporter activity +is_a: GO:1901478 ! aminotriazole transmembrane transporter activity + +[Term] +id: GO:0015315 +name: organophosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] +is_a: GO:0015114 ! phosphate ion transmembrane transporter activity +is_a: GO:0140323 ! solute:anion antiporter activity + +[Term] +id: GO:0015316 +name: obsolete nitrite/nitrate porter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "nitrite/nitrate porter activity" EXACT [] +is_obsolete: true +consider: GO:0015112 +consider: GO:0015113 +consider: GO:0015291 + +[Term] +id: GO:0015317 +name: phosphate:proton symporter activity +namespace: molecular_function +alt_id: GO:0015320 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] +synonym: "phosphate ion carrier activity" EXACT [] +synonym: "phosphate:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015318 +name: inorganic molecular entity transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] +subset: gocheck_do_not_annotate +synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] +synonym: "inorganic uptake permease activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015319 +name: sodium:inorganic phosphate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] +is_a: GO:0005315 ! inorganic phosphate transmembrane transporter activity +is_a: GO:0005436 ! sodium:phosphate symporter activity + +[Term] +id: GO:0015322 +name: secondary active oligopeptide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] +synonym: "oligopeptide porter activity" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:0015323 +name: obsolete type V protein secretor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +synonym: "type V protein secretor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015324 +name: peptide-acetyl-CoA secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "peptide-acetyl-CoA transporter activity" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015325 +name: acetyl-CoA:CoA antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] +is_a: GO:0008521 ! acetyl-CoA transmembrane transporter activity +is_a: GO:0015228 ! coenzyme A transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity + +[Term] +id: GO:0015327 +name: cystine:glutamate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] +is_a: GO:0005313 ! L-glutamate transmembrane transporter activity +is_a: GO:0015328 ! cystine secondary active transmembrane transporter activity +is_a: GO:0140323 ! solute:anion antiporter activity + +[Term] +id: GO:0015328 +name: cystine secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "cystine porter activity" RELATED [] +synonym: "cystinosin" NARROW [] +synonym: "lysosomal cystine transporter" NARROW [] +is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity + +[Term] +id: GO:0015330 +name: high-affinity glutamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity glutamine permease activity" RELATED [] +synonym: "high affinity glutamine transmembrane transporter activity" EXACT [] +is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity +is_a: GO:0015186 ! L-glutamine transmembrane transporter activity + +[Term] +id: GO:0015331 +name: obsolete asparagine/glutamine permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "asparagine/glutamine permease activity" EXACT [] +is_obsolete: true +consider: GO:0015182 +consider: GO:0015186 +consider: GO:0022857 + +[Term] +id: GO:0015332 +name: obsolete leucine/valine/isoleucine permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "leucine/valine/isoleucine permease activity" EXACT [] +is_obsolete: true +consider: GO:0005304 +consider: GO:0015188 +consider: GO:0015190 +consider: GO:0022857 + +[Term] +id: GO:0015333 +name: peptide:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] +synonym: "peptide:hydrogen symporter activity" EXACT [] +xref: Reactome:R-HSA-427998 "Proton-coupled di- and tri-peptide cotransport" +xref: Reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport" +xref: RHEA:37047 +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0015334 +name: high-affinity oligopeptide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] +synonym: "high affinity oligopeptide transporter activity" EXACT [] +synonym: "high-affinity oligopeptide transporter activity" RELATED [] +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:0015335 +name: obsolete heavy metal ion:hydrogen symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "heavy metal ion:hydrogen symporter activity" EXACT [] +synonym: "heavy metal ion:proton symporter activity" EXACT [] +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015336 +name: obsolete high affinity metal ion uptake transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "high affinity metal ion uptake transporter activity" EXACT [] +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015337 +name: obsolete low affinity metal ion uptake transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "low affinity metal ion uptake transporter activity" EXACT [] +is_obsolete: true +consider: GO:0015295 +consider: GO:0046873 + +[Term] +id: GO:0015339 +name: obsolete cobalt, zinc uptake permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1] +comment: This term was made obsolete because it represents more than one molecular function. +synonym: "cobalt, zinc uptake permease activity" EXACT [] +is_obsolete: true +consider: GO:0005385 +consider: GO:0015087 + +[Term] +id: GO:0015340 +name: obsolete zinc, cadmium uptake permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2] +comment: This term was made obsolete because it represents more than one molecular function. +synonym: "zinc, cadmium uptake permease activity" EXACT [] +is_obsolete: true +consider: GO:0005385 +consider: GO:0015086 + +[Term] +id: GO:0015341 +name: zinc efflux active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] +synonym: "zinc efflux permease activity" BROAD [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0022883 ! zinc efflux transmembrane transporter activity + +[Term] +id: GO:0015342 +name: obsolete zinc, iron permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-] +comment: This term was made obsolete because it represents more than one molecular function. +synonym: "zinc, iron permease activity" EXACT [] +is_obsolete: true +consider: GO:0005381 +consider: GO:0005385 + +[Term] +id: GO:0015343 +name: siderophore transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015236 +alt_id: GO:0015237 +alt_id: GO:0042927 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] +synonym: "iron-siderophore transporter activity" EXACT [] +synonym: "siderochrome transporter activity" NARROW [] +synonym: "siderochrome-iron transporter activity" NARROW [] +synonym: "siderophore transporter activity" RELATED [] +synonym: "siderophore-iron transmembrane transporter activity" RELATED [] +synonym: "siderophore-iron transporter activity" RELATED [] +xref: Reactome:R-HSA-1222597 "Loaded mycobactin gets imported" +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015344 +name: siderophore uptake transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] +synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED [] +synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] +synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED [] +is_a: GO:0015343 ! siderophore transmembrane transporter activity + +[Term] +id: GO:0015345 +name: ferric enterobactin:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] +synonym: "ferric enterobactin:hydrogen symporter activity" EXACT [] +synonym: "ferric-enterobactin:proton symporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015346 +name: ferric triacetylfusarinine C:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] +synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015343 ! siderophore transmembrane transporter activity +is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity + +[Term] +id: GO:0015347 +name: sodium-independent organic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] +xref: Reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates" +xref: Reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity" +xref: Reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity" +xref: Reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin" +xref: Reactome:R-HSA-9661397 "SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-9661446 "BMG, BDG translocates from ER lumen to cytosol" +xref: Reactome:R-HSA-9661723 "SLCO2B1-3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" +xref: Reactome:R-HSA-9661799 "SLCO1B3 transports BIL from extracellular region (blood) to cytosol (hepatocyte)" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015348 +name: obsolete prostaglandin/thromboxane transporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "prostaglandin/thromboxane transporter activity" EXACT [] +is_obsolete: true +consider: GO:0008028 +consider: GO:0015132 + +[Term] +id: GO:0015349 +name: thyroid hormone transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] +xref: Reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol" +xref: Reactome:R-HSA-9631987 "SLCO1B1 transports T3,T4 from extracellular region to cytosol" +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015350 +name: methotrexate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] +synonym: "methotrexate transporter activity" RELATED [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0015351 +name: bilirubin secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] +synonym: "bilirubin porter activity" RELATED [] +synonym: "bilitranslocase" NARROW [] +is_a: GO:0015127 ! bilirubin transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015352 +name: obsolete secondary active sterol transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] +comment: This term was obsoleted because there is no evidence that this function exists. +synonym: "sterol porter activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0015355 +name: secondary active monocarboxylate transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] +synonym: "monocarboxylate porter activity" RELATED [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0015356 +name: obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" EXACT [] +is_obsolete: true +consider: GO:0015129 +consider: GO:0015130 +consider: GO:0015562 +consider: GO:0050833 + +[Term] +id: GO:0015358 +name: obsolete amino acid/choline transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "amino acid/choline transmembrane transporter activity" EXACT [] +is_obsolete: true +consider: GO:0015171 +consider: GO:0015220 + +[Term] +id: GO:0015360 +name: acetate:proton symporter activity +namespace: molecular_function +alt_id: GO:0015357 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] +synonym: "acetate:hydrogen symporter activity" EXACT [] +synonym: "hydrogen:acetate symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0043893 ! acetate:cation symporter activity + +[Term] +id: GO:0015361 +name: low-affinity sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] +synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD [] +synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT [] +xref: Reactome:R-HSA-433131 "NaDC1 co-transports dicarboxylic acids and a sodium ion" +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity + +[Term] +id: GO:0015362 +name: high-affinity sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] +synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD [] +synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT [] +xref: Reactome:R-HSA-433101 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion" +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity + +[Term] +id: GO:0015363 +name: obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" EXACT [] +is_obsolete: true +consider: GO:0005310 +consider: GO:0015138 +consider: GO:0015140 +consider: GO:0015141 +consider: GO:0015297 + +[Term] +id: GO:0015364 +name: dicarboxylate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015114 ! phosphate ion transmembrane transporter activity +is_a: GO:0140323 ! solute:anion antiporter activity + +[Term] +id: GO:0015366 +name: malate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] +synonym: "L-malic acid permease" RELATED [GOC:vw] +synonym: "L-malic acid:proton symporter activity" RELATED [GOC:vw] +synonym: "malate permease" RELATED [GOC:vw] +synonym: "malate:hydrogen symporter activity" EXACT [] +is_a: GO:0015140 ! malate transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015367 +name: oxoglutarate:malate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] +synonym: "2-oxoglutarate/malate carrier protein" EXACT [Wikipedia:Mitochondrial_carrier] +xref: Reactome:R-HSA-198440 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]" +xref: Reactome:R-HSA-376851 "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" +is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity +is_a: GO:0015140 ! malate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015368 +name: calcium:cation antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] +xref: Reactome:R-HSA-425822 "K+-independent Li+/Ca2+ exchanger transport" +is_a: GO:0015085 ! calcium ion transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0015369 +name: calcium:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] +synonym: "calcium:hydrogen antiporter activity" EXACT [] +xref: Reactome:R-HSA-8949687 "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" +xref: RHEA:29671 +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0015368 ! calcium:cation antiporter activity +is_a: GO:0051139 ! metal ion:proton antiporter activity + +[Term] +id: GO:0015370 +name: solute:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] +xref: Reactome:R-HSA-8876283 "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol" +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015371 +name: galactose:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015372 +name: obsolete glutamate/aspartate:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "glutamate/aspartate:sodium symporter activity" EXACT [] +is_obsolete: true +consider: GO:0005283 +consider: GO:0005313 +consider: GO:0015183 + +[Term] +id: GO:0015373 +name: anion:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] +synonym: "monovalent anion:sodium symporter activity" EXACT [] +is_a: GO:0015296 ! anion:cation symporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015374 +name: neutral, basic amino acid:sodium:chloride symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] +synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED [] +is_a: GO:0005283 ! amino acid:sodium symporter activity + +[Term] +id: GO:0015375 +name: glycine:sodium symporter activity +namespace: molecular_function +alt_id: GO:0015656 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] +xref: Reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5660840 "Defective SLC6A5 does not cotransport Gly, Cl-, Na+ from extracellular region to cytosol" +is_a: GO:0005295 ! neutral amino acid:sodium symporter activity +is_a: GO:0015187 ! glycine transmembrane transporter activity + +[Term] +id: GO:0015376 +name: obsolete betaine/GABA:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "betaine/GABA:sodium symporter activity" EXACT [] +is_obsolete: true +consider: GO:0005332 +consider: GO:0015185 +consider: GO:0015199 +consider: GO:0015370 + +[Term] +id: GO:0015377 +name: cation:chloride symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] +synonym: "cation:chloride cotransporter activity" BROAD [] +is_a: GO:0015296 ! anion:cation symporter activity + +[Term] +id: GO:0015378 +name: sodium:chloride symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] +xref: Reactome:R-HSA-426130 "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol" +xref: Reactome:R-HSA-5623705 "Defective SLC12A3 does not cotransport Cl-, Na+ from extracellular region to cytosol" +is_a: GO:0015373 ! anion:sodium symporter activity +is_a: GO:0015377 ! cation:chloride symporter activity + +[Term] +id: GO:0015379 +name: potassium:chloride symporter activity +namespace: molecular_function +alt_id: GO:0022820 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] +synonym: "potassium ion symporter activity" BROAD [] +xref: Reactome:R-HSA-426155 "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" +xref: Reactome:R-HSA-5623806 "Defective SLC12A6 does not cotransport K+, Cl- from cytosol to extracellular region" +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015377 ! cation:chloride symporter activity + +[Term] +id: GO:0015381 +name: high-affinity sulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity sulfate permease activity" RELATED [] +synonym: "high affinity sulfate transmembrane transporter activity" EXACT [] +synonym: "high affinity sulphate permease activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity + +[Term] +id: GO:0015382 +name: sodium:sulfate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] +synonym: "sodium:sulfate cotransporter activity" BROAD [] +synonym: "sodium:sulphate symporter activity" EXACT [] +xref: Reactome:R-HSA-433099 "NaS2 co-transports sulphate and two sodium ions" +xref: Reactome:R-HSA-433114 "NaS1 co-transports sulphate and a sodium ion" +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015373 ! anion:sodium symporter activity + +[Term] +id: GO:0015383 +name: sulfate:bicarbonate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] +synonym: "sulphate:bicarbonate antiporter activity" EXACT [] +is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity +is_a: GO:0015106 ! bicarbonate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0015385 +name: sodium:proton antiporter activity +namespace: molecular_function +alt_id: GO:0015502 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] +synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] +synonym: "pH-dependent sodium:proton antiporter activity" NARROW [] +synonym: "sodium/hydrogen antiporter activity" EXACT [] +synonym: "sodium:hydrogen antiporter activity" EXACT [] +synonym: "sodium:hydrogen exchange activity" EXACT [] +synonym: "sodium:hydrogen exchanger" EXACT [] +xref: Reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+" +xref: Reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+" +xref: Reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane" +xref: Reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane" +xref: Reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)" +xref: Reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)" +xref: Reactome:R-HSA-5661039 "Defective SLC9A6 does not exchange Na+ for H+ across the early endosome membrane" +xref: Reactome:R-HSA-5661086 "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane" +xref: RHEA:29251 +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0051139 ! metal ion:proton antiporter activity + +[Term] +id: GO:0015386 +name: potassium:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] +synonym: "potassium:hydrogen antiporter activity" EXACT [] +xref: RHEA:29467 +is_a: GO:0005451 ! monovalent cation:proton antiporter activity +is_a: GO:0022821 ! potassium ion antiporter activity + +[Term] +id: GO:0015387 +name: potassium:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] +synonym: "potassium:hydrogen symporter activity" EXACT [] +xref: RHEA:28490 +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015389 +name: pyrimidine- and adenine-specific:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] +is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity +is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity +is_a: GO:0005415 ! nucleoside:sodium symporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity + +[Term] +id: GO:0015390 +name: purine-specific nucleoside:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015391 +name: nucleobase:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] +is_a: GO:0015205 ! nucleobase transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015393 +name: obsolete uracil/uridine permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "uracil/uridine permease activity" EXACT [] +is_obsolete: true +consider: GO:0015210 +consider: GO:0015213 +consider: GO:0022857 + +[Term] +id: GO:0015394 +name: uridine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] +synonym: "nucleoside (uridine) permease activity" RELATED [] +synonym: "uridine:hydrogen ion symporter activity" EXACT [] +is_a: GO:0015213 ! uridine transmembrane transporter activity +is_a: GO:0015506 ! nucleoside:proton symporter activity + +[Term] +id: GO:0015395 +name: nucleoside transmembrane transporter activity, down a concentration gradient +namespace: molecular_function +alt_id: GO:0015396 +alt_id: GO:0015397 +def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] +synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW [] +synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW [] +synonym: "equilibrative nucleoside transporter activity" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0015398 +name: high-affinity secondary active ammonium transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] +synonym: "high affinity secondary active ammonium transmembrane transporter activity" EXACT [] +is_a: GO:0008519 ! ammonium transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015399 +name: primary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] +synonym: "primary active transporter" RELATED [] +xref: TC:3 +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0015400 +name: low-affinity secondary active ammonium transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] +synonym: "low affinity secondary active ammonium transmembrane transporter activity" EXACT [] +is_a: GO:0008519 ! ammonium transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015401 +name: urea:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] +synonym: "urea active transmembrane transporter activity" EXACT [] +is_a: GO:0015204 ! urea transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity + +[Term] +id: GO:0015406 +name: obsolete ABC-type uptake permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +synonym: "ABC-type uptake permease activity" EXACT [] +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015407 +name: ABC-type monosaccharide transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:7.5.2.-] +synonym: "ATP-dependent monosaccharide transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled monosaccharide transmembrane transporter activity" RELATED [] +synonym: "monosaccharide ABC transporter" NARROW [] +synonym: "monosaccharide-importing ATPase activity" NARROW [] +synonym: "monosaccharide-transporting ATPase activity" EXACT [] +xref: EC:7.5.2.- +xref: MetaCyc:3.6.3.17-RXN +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0043211 ! ABC-type carbohydrate transporter activity + +[Term] +id: GO:0015408 +name: ABC-type ferric iron transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [RHEA:12332] +synonym: "ABC-type Fe3+ transporter" EXACT [] +synonym: "ATPase-coupled ferric iron transmembrane transporter activity" RELATED [] +synonym: "Fe3+-transporting ATPase activity" RELATED [EC:7.2.2.7] +synonym: "ferric ABC transporter" EXACT [] +synonym: "ferric transporting ATPase activity" RELATED [] +synonym: "ferric-transporting ATPase activity" RELATED [] +xref: EC:7.2.2.7 +xref: MetaCyc:3.6.3.30-RXN +xref: RHEA:12332 +is_a: GO:0015091 ! ferric iron transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015410 +name: ABC-type manganese transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [RHEA:17365] +synonym: "ABC-type Mn(2+) transporter" RELATED [EC:7.2.2.5] +synonym: "ATP-dependent manganese transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled manganese transmembrane transporter activity" RELATED [] +synonym: "manganese ABC transporter" NARROW [] +synonym: "manganese transmembrane transporter activity, phosphorylative mechanism" RELATED [] +synonym: "manganese-transporting ATPase activity" RELATED [EC:7.2.2.5] +xref: EC:7.2.2.5 +xref: MetaCyc:3.6.3.35-RXN +xref: Reactome:R-HSA-5692462 "ATP13A1 transports Mn2+ from cytosol to ER lumen" +xref: RHEA:17365 +is_a: GO:0005384 ! manganese ion transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015411 +name: ABC-type taurine transporter transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [RHEA:14613] +synonym: "ATP-dependent taurine transporter activity" RELATED [] +synonym: "ATPase-coupled taurine transporter activity" RELATED [] +synonym: "taurine ABC transporter" EXACT [EC:7.6.2.7] +synonym: "taurine-transporting ATPase activity" RELATED [EC:7.6.2.7] +xref: EC:7.6.2.7 +xref: MetaCyc:3.6.3.36-RXN +xref: MetaCyc:ABC-64-RXN +xref: RHEA:14613 +is_a: GO:0005368 ! taurine transmembrane transporter activity +is_a: GO:0008559 ! ABC-type xenobiotic transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity + +[Term] +id: GO:0015412 +name: ABC-type molybdate transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [RHEA:22020] +synonym: "ATPase-coupled molybdate transmembrane transporter activity" RELATED [] +synonym: "molybdate ABC transporter" EXACT [EC:7.3.2.5] +synonym: "molybdate porter activity" BROAD [] +synonym: "molybdate transmembrane-transporting ATPase activity" RELATED [] +synonym: "molybdate transporting ATPase activity" RELATED [] +synonym: "molybdate-transporting ATPase activity" RELATED [EC:7.3.2.5] +xref: EC:7.3.2.5 +xref: MetaCyc:3.6.3.29-RXN +xref: RHEA:22020 +is_a: GO:0015098 ! molybdate ion transmembrane transporter activity +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015413 +name: ABC-type nickel transporter activity +namespace: molecular_function +alt_id: GO:0102016 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [RHEA:15557] +synonym: "ATP-dependent nickel transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled nickel transmembrane transporter activity" RELATED [] +synonym: "nickel ABC transporter" EXACT [] +synonym: "nickel ABC transporter activity" EXACT [] +synonym: "nickel porter activity" RELATED [] +synonym: "nickel transporting ATPase activity" RELATED [] +synonym: "nickel-transporting ATPase activity" RELATED [] +xref: EC:7.2.2.11 +xref: MetaCyc:3.6.3.24-RXN +xref: MetaCyc:ABC-20-RXN +xref: RHEA:15557 +is_a: GO:0015099 ! nickel cation transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015414 +name: ABC-type nitrate transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [RHEA:13181] +synonym: "ATPase-coupled nitrate transmembrane transporter activity" RELATED [] +synonym: "nitrate ABC transporter" EXACT [] +synonym: "nitrate transmembrane-transporting ATPase activity" RELATED [] +synonym: "nitrate transporting ATPase activity" RELATED [] +synonym: "nitrate-transporting ATPase activity" RELATED [EC:7.3.2.4] +xref: EC:7.3.2.4 +xref: MetaCyc:3.6.3.26-RXN +xref: RHEA:13181 +is_a: GO:0015112 ! nitrate transmembrane transporter activity +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015415 +name: ATPase-coupled phosphate ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:7.3.2.1] +synonym: "ABC phosphate transporter activity" NARROW [EC:7.3.2.1] +synonym: "ATP phosphohydrolase (phosphate-importing)" RELATED [EC:7.3.2.1] +synonym: "phosphate ABC transporter" NARROW [] +synonym: "phosphate ion transmembrane-transporting ATPase activity" RELATED [] +synonym: "phosphate porter activity" EXACT [] +synonym: "phosphate transporting ATPase activity" EXACT [] +synonym: "phosphate-transporting ATPase activity" RELATED [EC:7.3.2.1] +xref: EC:7.3.2.1 +xref: RHEA:24440 +is_a: GO:0015114 ! phosphate ion transmembrane transporter activity +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015416 +name: ABC-type phosphonate transporter activity +namespace: molecular_function +alt_id: GO:0015604 +alt_id: GO:0042917 +alt_id: GO:0102017 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [RHEA:18065] +synonym: "alkylphosphonate ABC transporter activity" NARROW [] +synonym: "alkylphosphonate transmembrane transporter activity" NARROW [] +synonym: "alkylphosphonate transmembrane-transporting ATPase activity" NARROW [] +synonym: "ATP phosphohydrolase (phosphonate-transporting)" RELATED [] +synonym: "ATPase-coupled alkylphosphonate transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled organic phosphonate transmembrane transporter activity" RELATED [] +synonym: "organic phosphonate transmembrane transporter activity" BROAD [] +synonym: "organic phosphonate transmembrane-transporting ATPase activity" RELATED [] +synonym: "phosphonate ABC transporter" EXACT [] +synonym: "phosphonate transporting ATPase activity" RELATED [] +synonym: "phosphonate-transporting ATPase activity" RELATED [] +xref: EC:7.3.2.2 +xref: MetaCyc:3.6.3.28-RXN +xref: MetaCyc:ABC-23-RXN +xref: RHEA:18065 +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015417 +name: ABC-type polyamine transporter activity +namespace: molecular_function +alt_id: GO:0015595 +def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [RHEA:29999] +synonym: "ATP-dependent polyamine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled polyamine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled spermidine transmembrane transporter activity" NARROW [] +synonym: "polyamine ABC transporter" NARROW [EC:7.6.2.11] +synonym: "polyamine porter activity" BROAD [] +synonym: "polyamine-importing ATPase activity" NARROW [] +synonym: "polyamine-transporting ATPase activity" RELATED [EC:7.6.2.11] +synonym: "spermidine porter activity" NARROW [] +synonym: "spermidine-importing ATPase activity" NARROW [] +xref: EC:7.6.2.11 +xref: MetaCyc:3.6.3.31-RXN +xref: MetaCyc:ABC-24-RXN +xref: RHEA:29999 +is_a: GO:0015203 ! polyamine transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015418 +name: ABC-type quaternary ammonium compound transporting activity +namespace: molecular_function +alt_id: GO:0102908 +def: "Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in)." [GOC:pz, RHEA:11036] +synonym: "ATP-dependent quaternary-ammonium compound transmembrane transporting activity" RELATED [] +synonym: "ATPase-coupled quaternary ammonium compound transmembrane transporting activity" RELATED [] +synonym: "glycine betaine/proline porter activity" NARROW [] +synonym: "quarternary amine transporter activity" BROAD [] +synonym: "quaternary amine uptake transporter activity" RELATED [] +synonym: "quaternary-amine-transporting ATPase activity" RELATED [] +synonym: "quaternary-ammonium-compound ABC transporter" EXACT [] +synonym: "quaternary-ammonium-compound-transporting ATPase activity" RELATED [] +xref: EC:7.6.2.9 +xref: MetaCyc:3.6.3.32-RXN +xref: MetaCyc:RXN-8638 +xref: RHEA:11036 +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015419 +name: ABC-type sulfate transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [RHEA:10192] +synonym: "ATPase-coupled sulfate transmembrane transporter activity" RELATED [] +synonym: "sulfate ABC transporter" EXACT [] +synonym: "sulfate transmembrane-transporting ATPase activity" RELATED [] +synonym: "sulfate-transporting ATPase activity" RELATED [EC:7.3.2.3] +synonym: "sulfate/thiosulfate porter activity" BROAD [] +synonym: "sulphate transporting ATPase activity" RELATED [] +xref: EC:7.3.2.3 +xref: MetaCyc:3.6.3.25-RXN +xref: RHEA:10192 +is_a: GO:0015116 ! sulfate transmembrane transporter activity +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015420 +name: ABC-type vitamin B12 transporter activity +namespace: molecular_function +alt_id: GO:0015235 +alt_id: GO:0102023 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin." [GOC:pz, RHEA:17873] +synonym: "ATP-dependent cobalamin transmembrane transporter activity" RELATED [] +synonym: "ATP-dependent vitamin B12 transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled cobalamin transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled vitamin B12 transmembrane transporter activity" RELATED [] +synonym: "cobalamin ABC transporter" EXACT [] +synonym: "cobalamin porter activity" BROAD [] +synonym: "cobalamin transporter activity" BROAD [] +synonym: "cobalamin-transporting ATPase activity" RELATED [] +synonym: "vitamin B12 ABC transporter activity" EXACT [] +synonym: "vitamin B12 porter activity" BROAD [] +synonym: "vitamin B12 transporter activity" BROAD [] +synonym: "vitamin B12-transporting ATPase activity" BROAD [] +xref: EC:7.6.2.8 +xref: MetaCyc:3.6.3.33-RXN +xref: MetaCyc:ABC-5-RXN +xref: Reactome:R-HSA-3000238 "LMBRD1 transports lysosomal Cbl to cytosol" +xref: Reactome:R-HSA-3095901 "ABCC1 transports cytosolic Cbl to extracellular region" +xref: Reactome:R-HSA-3315437 "Defective LMBRD1 does not transport lysosomal Cbl to cytosol" +xref: RHEA:17873 +is_a: GO:0090482 ! vitamin transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015421 +name: ABC-type oligopeptide transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [RHEA:37271] +synonym: "ABC-type oligopeptide transporter" EXACT [EC:7.4.2.6] +synonym: "ATP-dependent oligopeptide transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled oligopeptide transmembrane transporter activity" RELATED [] +synonym: "oligopeptide ABC transporter" NARROW [] +synonym: "oligopeptide permease activity" RELATED [EC:7.4.2.6] +synonym: "oligopeptide-transporting ATPase activity" RELATED [EC:7.4.2.6] +xref: EC:7.4.2.6 +xref: MetaCyc:3.6.3.23-RXN +xref: Reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen" +xref: RHEA:37271 +is_a: GO:0015440 ! ABC-type peptide transporter activity +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:0015422 +name: ABC-type oligosaccharide transporter activity +namespace: molecular_function +alt_id: GO:0015609 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:7.5.2.2] +synonym: "ABC-type oligosaccharide transporter" RELATED [EC:7.5.2.2] +synonym: "ATP-dependent oligosaccharide transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled oligosaccharide transmembrane transporter activity" RELATED [] +synonym: "oligosaccharide ABC transporter" EXACT [] +synonym: "oligosaccharide-transporting ATPase activity" RELATED [EC:7.5.2.2] +xref: EC:7.5.2.2 +xref: MetaCyc:3.6.3.18-RXN +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity +is_a: GO:0043211 ! ABC-type carbohydrate transporter activity + +[Term] +id: GO:0015423 +name: ABC-type maltose transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [RHEA:22132] +synonym: "ABC-type maltose transporter" EXACT [EC:7.5.2.1] +synonym: "ATP-dependent maltose transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled maltose transmembrane transporter activity" RELATED [] +synonym: "maltooligosaccharide-importing ATPase activity" RELATED [] +synonym: "maltose ABC transporter" EXACT [] +synonym: "maltose-transporting ATPase activity" RELATED [EC:7.5.2.1] +xref: EC:7.5.2.1 +xref: MetaCyc:3.6.3.19-RXN +xref: RHEA:22132 +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0015422 ! ABC-type oligosaccharide transporter activity + +[Term] +id: GO:0015424 +name: ABC-type amino acid transporter activity +namespace: molecular_function +alt_id: GO:0032518 +alt_id: GO:0032520 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] +synonym: "amino acid ABC transporter" NARROW [] +synonym: "amino acid-exporting ATPase activity" RELATED [] +synonym: "amino acid-importing ATPase activity" RELATED [] +synonym: "amino acid-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent amino acid transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled amino acid transmembrane transporter activity" RELATED [] +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015425 +name: ATPase-coupled nonpolar-amino acid transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:7.4.2.2] +synonym: "ATP-dependent nonpolar-amino acid transporter activity" EXACT [] +synonym: "leucine/isoleucine/valine porter activity" RELATED [] +synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] +synonym: "nonpolar-amino acid ABC transporter" EXACT [] +synonym: "nonpolar-amino acid-transporting ATPase activity" EXACT [] +synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] +xref: EC:7.4.2.2 +xref: MetaCyc:3.6.3.22-RXN +xref: TC:3.A.1.4.1 +is_a: GO:0015424 ! ABC-type amino acid transporter activity + +[Term] +id: GO:0015426 +name: ATPase-coupled polar amino acid-transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:7.4.2.1] +synonym: "ATP-dependent polar amino acid-transporter activity" EXACT [] +synonym: "cystine/diaminopimelate porter activity" RELATED [] +synonym: "glutamate/aspartate porter activity" RELATED [] +synonym: "histidine permease activity" NARROW [EC:7.4.2.1] +synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] +synonym: "polar amino acid uptake transporter activity" EXACT [] +synonym: "polar amino acid-importing ATPase activity" EXACT [] +synonym: "polar-amino acid ABC transporter" NARROW [] +synonym: "polar-amino acid-importing ATPase activity" EXACT [] +synonym: "polar-amino acid-transporting ATPase activity" EXACT [] +synonym: "polar-amino-acid-transporting ATPase activity" RELATED [EC:7.4.2.1] +xref: EC:7.4.2.1 +xref: MetaCyc:3.6.3.21-RXN +xref: RHEA:14673 +is_a: GO:0015424 ! ABC-type amino acid transporter activity + +[Term] +id: GO:0015427 +name: obsolete ABC-type efflux porter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +synonym: "ABC-type efflux porter activity" EXACT [] +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015428 +name: obsolete type I protein secretor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +synonym: "type I protein secretor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015429 +name: obsolete peroxisomal fatty acyl transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and it contains both component and function information. +synonym: "peroxisomal fatty acyl transporter" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015430 +name: ABC-type glycerol-3-phosphate transporter activity +namespace: molecular_function +alt_id: GO:0015610 +alt_id: GO:0070812 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [RHEA:21668] +synonym: "ABC-type glycerol 3-phosphate transporter" EXACT [EC:7.6.2.10] +synonym: "ATP-dependent glycerol-2-phosphate transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled glycerol-2-phosphate transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled glycerol-3-phosphate transmembrane transporter activity" RELATED [] +synonym: "glycerol phosphate-importing ATPase activity" NARROW [] +synonym: "glycerol-2-phosphate-transporting ATPase activity" NARROW [] +synonym: "glycerol-3-phosphate ABC transporter" EXACT [EC:7.6.2.10] +synonym: "glycerol-3-phosphate-transporting ATPase" RELATED [EC:7.6.2.10] +synonym: "glycerol-phosphate porter activity" NARROW [] +xref: EC:7.6.2.10 +xref: MetaCyc:3.6.3.20-RXN +xref: RHEA:21668 +is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015431 +name: ABC-type glutathione S-conjugate transporter activity +namespace: molecular_function +alt_id: GO:0071997 +def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517, RHEA:19121] +synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] +synonym: "ATPase-coupled glutathione S-conjugate transmembrane transporter activity" RELATED [] +synonym: "conjugate transporter activity" BROAD [] +synonym: "glutathione S-conjugate-exporting ATPase activity" NARROW [] +synonym: "glutathione S-conjugate-transporting ATPase activity" RELATED [EC:7.6.2.3] +synonym: "GS-X pump" EXACT [] +synonym: "MRP1/GS-X pump" EXACT [] +xref: EC:7.6.2.3 +xref: RHEA:19121 +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015432 +name: ABC-type bile acid transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate." [RHEA:50048] +synonym: "ATP-dependent bile acid transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled bile acid transmembrane transporter activity" RELATED [] +synonym: "bile acid porter activity" NARROW [] +synonym: "bile acid-exporting ATPase activity" NARROW [] +xref: Reactome:R-HSA-193362 "ABCB11 transports bile salts from cytosol to extracellular region" +xref: Reactome:R-HSA-194153 "Transport (efflux) of bile salts by ABCC3 (MRP3)" +xref: Reactome:R-HSA-5678517 "Defective ABCB11 does not transport bile salts from cytosol to extracellular region" +xref: RHEA:50048 +xref: TC:3.A.1.207.2 +is_a: GO:0015125 ! bile acid transmembrane transporter activity +is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity +is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015433 +name: ABC-type peptide antigen transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] +synonym: "ATP-dependent peptide antigen transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled peptide antigen transmembrane transporter activity" RELATED [] +synonym: "major histocompatibility peptide transporter activity" EXACT [] +synonym: "peptide antigen ABC transporter" NARROW [] +synonym: "peptide antigen transporter activity" BROAD [] +synonym: "peptide antigen-transporting ATPase activity" EXACT [] +xref: Reactome:R-HSA-1236949 "Translocation of antigenic peptides back to phagosomes via TAP" +xref: Reactome:R-HSA-983144 "Transport of Antigen peptide in to ER" +xref: TC:3.A.1.209.1 +is_a: GO:0015440 ! ABC-type peptide transporter activity + +[Term] +id: GO:0015434 +name: ABC-type cadmium transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [PMID:12455987] +synonym: "ATP-dependent cadmium transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled cadmium transmembrane transporter activity" RELATED [] +synonym: "cadmium ABC transporter" EXACT [] +synonym: "cadmium-transporting ATPase activity" RELATED [EC:7.2.2.2] +xref: EC:7.2.2.2 +xref: MetaCyc:3.6.3.46-RXN +is_a: GO:0015086 ! cadmium ion transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015435 +name: obsolete ABC-type efflux permease activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. +synonym: "ABC-type efflux permease activity" EXACT [] +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0015436 +name: ABC-type capsular-polysaccharide transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:7.6.2.12] +synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" RELATED [EC:7.6.2.12] +synonym: "ATP-dependent capsular-polysaccharide transporter activity" EXACT [] +synonym: "ATPase-coupled capsular-polysaccharide transporter activity" RELATED [] +synonym: "capsular-polysaccharide ABC transporter" NARROW [] +synonym: "capsular-polysaccharide-transporting ATPase activity" EXACT [] +xref: EC:7.6.2.12 +xref: MetaCyc:3.6.3.38-RXN +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015437 +name: lipopolysaccharide floppase activity +namespace: molecular_function +def: "Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [EC:7.5.2.5] +synonym: "ATP-dependent intramembrane lipopolysaccharide transporter activity" EXACT [] +synonym: "ATPase-coupled intramembrane lipopolysaccharide transporter activity" BROAD [] +synonym: "lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "lipopolysaccharide-transporting ATPase activity" EXACT [] +synonym: "LPS-transporting ATPase activity" EXACT [] +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0015438 +name: ABC-type teichoic acid transporter activity +namespace: molecular_function +alt_id: GO:0015162 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [PMID:7565096] +synonym: "ABC-type teichoic-acid transporter" EXACT [EC:7.5.2.4] +synonym: "ATP-dependent teichoic acid transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled teichoic acid transmembrane transporter activity" RELATED [] +synonym: "teichoic acid transmembrane transporter activity" BROAD [] +synonym: "teichoic-acid ABC transporter" EXACT [] +synonym: "teichoic-acid-transporting ATPase activity" RELATED [EC:7.5.2.4] +xref: EC:7.5.2.4 +xref: MetaCyc:3.6.3.40-RXN +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015439 +name: ABC-type heme transporter activity +namespace: molecular_function +alt_id: GO:0103115 +def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [RHEA:19261] +synonym: "ATP-dependent heme transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled heme transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled heme transporter activity" RELATED [] +synonym: "haem-transporting ATPase activity" EXACT [] +synonym: "heme ABC transporter" NARROW [] +synonym: "heme-transporting ATPase activity" EXACT [] +synonym: "protoheme IX ABC transporter activity" RELATED [] +xref: EC:7.6.2.5 +xref: MetaCyc:3.6.3.41-RXN +xref: MetaCyc:TRANS-RXN0-162 +xref: Reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix" +xref: Reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport" +xref: Reactome:R-HSA-5683355 "Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix" +xref: Reactome:R-HSA-917979 "ABCG2 tetramer transports heme from cytosol to extracellular region" +xref: RHEA:19261 +is_a: GO:0015232 ! heme transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015440 +name: ABC-type peptide transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [RHEA:14429] +synonym: "ATP-dependent peptide transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled peptide transmembrane transporter activity" RELATED [] +synonym: "peptide ABC transporter" EXACT [] +synonym: "peptide-transporting ATPase activity" RELATED [] +xref: EC:7.4.2.5 +xref: MetaCyc:3.6.3.43-RXN +xref: RHEA:14429 +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0015441 +name: ABC-type beta-glucan transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [RHEA:18453] +synonym: "ABC-type beta-glucan transporter" RELATED [EC:7.5.2.3] +synonym: "ATP-dependent beta-glucan transporter activity" RELATED [] +synonym: "ATPase-coupled beta-glucan transporter activity" RELATED [] +synonym: "beta-glucan ABC transporter" EXACT [] +synonym: "beta-glucan-transporting ATPase activity" RELATED [EC:7.5.2.3] +xref: EC:7.5.2.3 +xref: MetaCyc:3.6.3.42-RXN +xref: RHEA:18453 +is_a: GO:0015160 ! beta-glucan transmembrane transporter activity +is_a: GO:0043211 ! ABC-type carbohydrate transporter activity + +[Term] +id: GO:0015442 +name: obsolete hydrogen-/sodium-translocating ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-] +comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification. +synonym: "hydrogen-/sodium-translocating ATPase activity" EXACT [] +synonym: "proton-/sodium-translocating ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0008553 +consider: GO:0008554 + +[Term] +id: GO:0015443 +name: obsolete sodium-transporting two-sector ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15] +comment: This term was made obsolete because it refers to a bifunctional gene product. +synonym: "sodium-transporting two-sector ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046932 +consider: GO:0046962 + +[Term] +id: GO:0015444 +name: P-type magnesium transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in)." [RHEA:10260] +synonym: "ATP phosphohydrolase (Mg2+-importing)" RELATED [EC:7.2.2.14] +synonym: "magnesium importing ATPase activity" EXACT [] +synonym: "magnesium transmembrane transporter activity, phosphorylative mechanism" RELATED [] +synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:7.2.2.14] +synonym: "Mg(2+)-importing ATPase activity" RELATED [EC:7.2.2.14] +synonym: "Mg2+-importing ATPase activity" RELATED [EC:7.2.2.14] +xref: EC:7.2.2.14 +xref: MetaCyc:3.6.3.2-RXN +xref: RHEA:10260 +is_a: GO:0015095 ! magnesium ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0015445 +name: P-type silver transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out)." [RHEA:14733] +synonym: "Ag+-exporting ATPase activity" RELATED [EC:7.2.2.15] +synonym: "ATP phosphohydrolase (Ag+-exporting)" RELATED [EC:7.2.2.15] +synonym: "silver exporting ATPase activity" EXACT [] +synonym: "silver transmembrane transporter activity, phosphorylative mechanism" EXACT [] +synonym: "silver-exporting ATPase activity" RELATED [] +xref: EC:7.2.2.15 +xref: MetaCyc:3.6.3.53-RXN +xref: RHEA:14733 +is_a: GO:0015080 ! silver ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0015446 +name: ATPase-coupled arsenite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [PMID:10970874, RHEA:11348] +comment: EC:7.3.2.7 states that this bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. Like ABC transporters, it contains two nucleotide binding sites (PMID:10970874). +synonym: "arsenical pump-driving ATPase activity" RELATED [EC:7.3.2.7] +synonym: "arsenical resistance ATPase activity" RELATED [EC:7.3.2.7] +synonym: "arsenical resistance efflux pump" RELATED [] +synonym: "arsenite ABC transporter" NARROW [] +synonym: "arsenite transporting ATPase activity" EXACT [] +synonym: "arsenite-translocating ATPase activity" RELATED [EC:7.3.2.7] +synonym: "arsenite-transmembrane transporting ATPase activity" RELATED [] +synonym: "arsenite-transporting ATPase activity" RELATED [EC:7.3.2.7, GOC:vw] +xref: EC:7.3.2.7 +xref: MetaCyc:3.6.3.16-RXN +xref: RHEA:11348 +xref: TC:3.A.4.1.1 +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity +is_a: GO:1901683 ! arsenate ion transmembrane transporter activity + +[Term] +id: GO:0015447 +name: obsolete type II protein secretor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +synonym: "type II protein secretor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015448 +name: obsolete type III protein (virulence-related) secretor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +synonym: "type III protein (virulence-related) secretor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015449 +name: obsolete type IV protein (DNA-protein) secretor activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport] +comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. +synonym: "type IV protein (DNA-protein) secretor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015450 +name: protein-transporting ATPase activity +namespace: molecular_function +def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] +synonym: "P-P-bond-hydrolysis-driven protein transmembrane transporter activity" RELATED [] +synonym: "protein translocase activity" EXACT [] +xref: Reactome:R-HSA-1222523 "SodB gets secreted" +is_a: GO:0008320 ! protein transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0015451 +name: decarboxylation-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] +synonym: "decarboxylation-driven transporter" RELATED [] +xref: EC:7.2.4.1 +xref: EC:7.2.4.2 +xref: EC:7.2.4.3 +xref: EC:7.2.4.4 +xref: EC:7.2.4.5 +xref: TC:3.B +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015452 +name: methyl transfer-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] +synonym: "Methyltransfer-driven transporters" EXACT [] +xref: TC:3.C +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015453 +name: oxidoreduction-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] +synonym: "oxidoreduction-driven transporter" EXACT [] +xref: TC:3.D +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015454 +name: light-driven active transmembrane transporter activity +namespace: molecular_function +def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] +synonym: "Light absorption-driven transporters" EXACT [] +synonym: "light-driven pumps" EXACT [] +xref: TC:3.E +is_a: GO:0015399 ! primary active transmembrane transporter activity + +[Term] +id: GO:0015459 +name: potassium channel regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a potassium channel." [GOC:dos, GOC:mah] +synonym: "potassium channel gating activity" EXACT [] +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0015461 +name: obsolete endosomal oligosaccharide transporter +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "endosomal oligosaccharide transporter" EXACT [] +is_obsolete: true +consider: GO:0005768 +consider: GO:0015157 + +[Term] +id: GO:0015462 +name: ABC-type protein transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [GOC:jl] +comment: Enzymes with this activity include bacterial enzymes dedicated to the secretion of one or several closely related proteins belonging to the toxin, protease and lipase families, for example alpha-hemolysin, cyclolysin, colicin V, siderophores, bacteriocin, subtilin, competence factor and pediocin (from EC:7.4.2.5). +synonym: "ABC-type protein transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled protein transmembrane transporter activity" RELATED [] +synonym: "pilin/fimbrilin exporter activity" NARROW [] +synonym: "protein ABC transporter" EXACT [] +synonym: "protein-transmembrane transporting ATPase activity" RELATED [] +synonym: "protein-transporting ATPase activity" BROAD [] +xref: EC:7.4.2.5 +is_a: GO:0015450 ! protein-transporting ATPase activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015464 +name: acetylcholine receptor activity +namespace: molecular_function +def: "Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity + +[Term] +id: GO:0015465 +name: obsolete lysin activity +namespace: molecular_function +def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "lysin activity" EXACT [] +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015466 +name: obsolete autolysin activity +namespace: molecular_function +def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "autolysin activity" EXACT [] +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015467 +name: G-protein activated inward rectifier potassium channel activity +namespace: molecular_function +alt_id: GO:0015273 +def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] +synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] +synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] +synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT [] +synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] +synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] +xref: Reactome:R-HSA-1013020 "Activation of GIRK/Kir3 Channels" +is_a: GO:0005242 ! inward rectifier potassium channel activity + +[Term] +id: GO:0015468 +name: obsolete colicin +namespace: molecular_function +def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "colicin" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005198 +consider: GO:0019835 +consider: GO:0046930 +consider: GO:0046931 +consider: GO:0090729 + +[Term] +id: GO:0015469 +name: obsolete channel-forming toxin activity +namespace: molecular_function +def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "channel-forming toxin activity" EXACT [] +is_obsolete: true +consider: GO:0015267 +consider: GO:0035915 +consider: GO:0046930 +consider: GO:0090729 + +[Term] +id: GO:0015470 +name: obsolete bacteriocin activity +namespace: molecular_function +def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "bacteriocin activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0019835 + +[Term] +id: GO:0015471 +name: nucleoside-specific channel forming porin activity +namespace: molecular_function +def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015472 +name: obsolete fimbrium-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046] +comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function. +synonym: "fimbrium-specific chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0009297 +consider: GO:0030674 +consider: GO:0044183 +consider: GO:0051082 + +[Term] +id: GO:0015473 +name: fimbrial usher porin activity +namespace: molecular_function +def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015474 +name: autotransporter activity +namespace: molecular_function +def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015475 +name: adhesin autotransporter activity +namespace: molecular_function +def: "Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015474 ! autotransporter activity + +[Term] +id: GO:0015476 +name: hemaglutinin autotransporter activity +namespace: molecular_function +def: "Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015474 ! autotransporter activity + +[Term] +id: GO:0015477 +name: obsolete receptor porin activity +namespace: molecular_function +def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-] +comment: This term was made obsolete because it combines two functions that are not linked. +synonym: "receptor porin activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015478 +name: oligosaccharide transporting porin activity +namespace: molecular_function +def: "Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +synonym: "raffinose porin" NARROW [] +is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015479 +name: obsolete outer membrane exporter porin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "outer membrane exporter porin" EXACT [] +is_obsolete: true +consider: GO:0009279 +consider: GO:0015288 + +[Term] +id: GO:0015480 +name: obsolete secretin (sensu Bacteria) +namespace: molecular_function +def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "secretin (sensu Bacteria)" EXACT [] +is_obsolete: true +consider: GO:0008320 +consider: GO:0045203 + +[Term] +id: GO:0015481 +name: maltose transporting porin activity +namespace: molecular_function +def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] +synonym: "maltoporin" EXACT [] +xref: Wikipedia:Maltoporin +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015482 +name: obsolete voltage-gated anion channel porin activity +namespace: molecular_function +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity. +synonym: "voltage-dependent anion channel porin activity" EXACT [] +synonym: "voltage-gated anion channel porin activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015483 +name: long-chain fatty acid transporting porin activity +namespace: molecular_function +def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, TC:1.B.9.1.1] +xref: TC:1.B.9.1.1 +is_a: GO:0005324 ! long-chain fatty acid transporter activity +is_a: GO:0015245 ! fatty acid transmembrane transporter activity +is_a: GO:0015288 ! porin activity + +[Term] +id: GO:0015484 +name: obsolete hemolysin activity +namespace: molecular_function +def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "hemolysin activity" EXACT [] +is_obsolete: true +consider: GO:0019836 + +[Term] +id: GO:0015485 +name: cholesterol binding +namespace: molecular_function +def: "Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732] +is_a: GO:0032934 ! sterol binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0015486 +name: glycoside-pentoside-hexuronide:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] +is_a: GO:0005402 ! carbohydrate:cation symporter activity + +[Term] +id: GO:0015487 +name: melibiose:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] +synonym: "melibiose permease activity" RELATED [] +synonym: "melibiose:monovalent cation symporter activity" EXACT [] +is_a: GO:0005402 ! carbohydrate:cation symporter activity +is_a: GO:0015156 ! melibiose transmembrane transporter activity + +[Term] +id: GO:0015488 +name: glucuronide:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] +synonym: "glucuronide:monovalent cation symporter activity" EXACT [] +synonym: "glucuronoside permease activity" RELATED [] +is_a: GO:0015164 ! glucuronoside transmembrane transporter activity +is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity + +[Term] +id: GO:0015489 +name: putrescine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0015491 +name: cation:cation antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0015492 +name: phenylalanine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] +synonym: "phenylalanine:hydrogen symporter activity" EXACT [] +is_a: GO:0015494 ! aromatic amino acid:proton symporter activity + +[Term] +id: GO:0015493 +name: lysine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] +synonym: "lysine:hydrogen symporter activity" EXACT [] +is_a: GO:0005280 ! amino acid:proton symporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015494 +name: aromatic amino acid:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] +synonym: "aromatic amino acid:hydrogen symporter activity" EXACT [] +is_a: GO:0005280 ! amino acid:proton symporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity + +[Term] +id: GO:0015495 +name: gamma-aminobutyric acid:proton symporter activity +namespace: molecular_function +alt_id: GO:0005331 +alt_id: GO:0015329 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] +comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. +synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] +synonym: "4-aminobutanoate:proton symporter activity" EXACT [] +synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] +synonym: "4-aminobutyrate:proton symporter activity" EXACT [] +synonym: "GABA:hydrogen symporter activity" EXACT [] +synonym: "GABA:proton symporter activity" EXACT [] +synonym: "gamma-aminobutyric acid permease activity" EXACT [] +synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT [] +xref: Reactome:R-HSA-428625 "Vesicular inhibitory amino acid transport" +is_a: GO:0005280 ! amino acid:proton symporter activity +is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0015496 +name: putrescine:ornithine antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] +synonym: "putrescine-ornithine antiporter activity" EXACT [] +synonym: "putrescine/ornithine antiporter activity" EXACT [] +synonym: "putrescine:hydrogen symporter activity" EXACT [] +is_a: GO:0000064 ! L-ornithine transmembrane transporter activity +is_a: GO:0015489 ! putrescine transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity +is_a: GO:0140323 ! solute:anion antiporter activity + +[Term] +id: GO:0015498 +name: pantothenate:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015370 ! solute:sodium symporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015499 +name: formate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015659 +def: "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] +synonym: "formate uptake permease activity" EXACT [] +synonym: "formate uptake transmembrane transporter activity" RELATED [] +xref: RHEA:29679 +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015500 +name: obsolete threonine/serine:sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "threonine/serine:sodium symporter activity" EXACT [] +is_obsolete: true +consider: GO:0005283 +consider: GO:0015194 +consider: GO:0015195 + +[Term] +id: GO:0015501 +name: glutamate:sodium symporter activity +namespace: molecular_function +alt_id: GO:0008027 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] +synonym: "sodium/excitatory glutamate cotransporter activity" BROAD [] +synonym: "sodium/excitatory glutamate symporter activity" EXACT [] +xref: RHEA:29031 +is_a: GO:0005283 ! amino acid:sodium symporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015503 +name: glutathione-regulated potassium exporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015504 +name: cytosine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] +synonym: "cytosine permease activity" RELATED [] +synonym: "cytosine:hydrogen ion symporter activity" EXACT [] +is_a: GO:0015209 ! cytosine transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity + +[Term] +id: GO:0015505 +name: uracil:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] +synonym: "uracil permease activity" RELATED [] +is_a: GO:0015210 ! uracil transmembrane transporter activity +is_a: GO:0015391 ! nucleobase:cation symporter activity + +[Term] +id: GO:0015506 +name: nucleoside:proton symporter activity +namespace: molecular_function +alt_id: GO:0015536 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] +synonym: "nucleoside permease activity" RELATED [] +synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] +synonym: "nucleoside:hydrogen symporter activity" EXACT [] +is_a: GO:0005337 ! nucleoside transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015507 +name: obsolete hydroxy/aromatic amino acid permease activity +namespace: molecular_function +def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +synonym: "hydroxy/aromatic amino acid permease activity" EXACT [] +is_obsolete: true +consider: GO:0015171 +consider: GO:0015173 + +[Term] +id: GO:0015513 +name: high-affinity secondary active nitrite transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] +synonym: "nitrite uptake permease activity" EXACT [] +is_a: GO:0015112 ! nitrate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015514 +name: nitrite efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "nitrite extrusion permease activity" EXACT [] +is_a: GO:0015113 ! nitrite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015515 +name: citrate:succinate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity + +[Term] +id: GO:0015516 +name: tartrate:succinate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015554 ! tartrate transmembrane transporter activity + +[Term] +id: GO:0015517 +name: galactose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] +synonym: "galactose:hydrogen symporter activity" EXACT [] +synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0009679 ! hexose:proton symporter activity + +[Term] +id: GO:0015518 +name: arabinose:proton symporter activity +namespace: molecular_function +alt_id: GO:0015523 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] +synonym: "arabinose efflux permease activity" BROAD [] +synonym: "arabinose efflux transmembrane transporter activity" BROAD [] +synonym: "arabinose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0042900 ! arabinose transmembrane transporter activity + +[Term] +id: GO:0015519 +name: D-xylose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] +synonym: "D-xylose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0015148 ! D-xylose transmembrane transporter activity + +[Term] +id: GO:0015520 +name: tetracycline:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] +synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] +synonym: "tetracyclin:proton antiporter activity" EXACT [] +synonym: "tetracycline:hydrogen antiporter activity" EXACT [] +is_a: GO:0008493 ! tetracycline transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0015521 +name: obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" EXACT [] +synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT [] +synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT [] +is_obsolete: true +consider: GO:0015545 +consider: GO:0015546 +consider: GO:0045119 + +[Term] +id: GO:0015522 +name: obsolete hydrophobic uncoupler:proton antiporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] +comment: The reason for obsoletion is that this term represented a specific protein in TCDB, 2.A.1.2.9, which actually is a sugar transporter that seems to also function as a multidrug efflux protein. +synonym: "hydrophobic uncoupler:hydrogen antiporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015524 +name: obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15] +comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function. +synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" EXACT [] +synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT [] +is_obsolete: true +consider: GO:0015147 +consider: GO:0015299 +consider: GO:0051119 + +[Term] +id: GO:0015525 +name: obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" EXACT [] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT [] +is_obsolete: true +consider: GO:0015547 +consider: GO:0015548 +consider: GO:0015549 + +[Term] +id: GO:0015526 +name: hexose-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] +is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0015527 +name: glycerol-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015528 +name: lactose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] +synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] +synonym: "lactose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0015155 ! lactose transmembrane transporter activity + +[Term] +id: GO:0015529 +name: raffinose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] +synonym: "raffinose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0015158 ! raffinose transmembrane transporter activity + +[Term] +id: GO:0015530 +name: shikimate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015531 +name: citrate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] +synonym: "citrate:hydrogen symporter activity" EXACT [] +xref: RHEA:32123 +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity + +[Term] +id: GO:0015532 +name: alpha-ketoglutarate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] +synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] +synonym: "2-oxoglutarate:proton symporter activity" EXACT [] +synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT [] +is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015533 +name: shikimate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] +synonym: "shikimate:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity +is_a: GO:0015530 ! shikimate transmembrane transporter activity + +[Term] +id: GO:0015534 +name: obsolete proline/glycine/betaine:hydrogen/sodium symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" EXACT [] +synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT [] +is_obsolete: true +consider: GO:0015187 +consider: GO:0015193 +consider: GO:0015199 +consider: GO:0015294 +consider: GO:0015295 +consider: GO:0015370 + +[Term] +id: GO:0015535 +name: fucose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] +synonym: "fucose:hydrogen symporter activity" EXACT [] +xref: RHEA:29023 +is_a: GO:0009679 ! hexose:proton symporter activity +is_a: GO:0015150 ! fucose transmembrane transporter activity + +[Term] +id: GO:0015537 +name: xanthosine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] +synonym: "xanthosine permease activity" RELATED [] +synonym: "xanthosine:hydrogen ion symporter activity" EXACT [] +is_a: GO:0015506 ! nucleoside:proton symporter activity +is_a: GO:0015553 ! xanthosine transmembrane transporter activity + +[Term] +id: GO:0015538 +name: sialic acid:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] +synonym: "sialic acid permease activity" RELATED [] +synonym: "sialic acid:hydrogen symporter activity" EXACT [] +xref: Reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-5624239 "Defective SLC17A5 does not cotransport Neu5Ac, H+ from lysosomal lumen to cytosol" +xref: RHEA:28987 +is_a: GO:0015136 ! sialic acid transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0015539 +name: hexuronate:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] +synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] +synonym: "hexuronate porter activity" RELATED [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity + +[Term] +id: GO:0015540 +name: 3-hydroxyphenyl propionate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] +synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] +synonym: "3-hydroxyphenyl propionate:hydrogen ion symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity + +[Term] +id: GO:0015541 +name: secondary active cyanate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cyanate from one side of a membrane to the other." [TC:2.A.1.17.1] +synonym: "cyanate porter activity" RELATED [] +is_a: GO:0015110 ! cyanate transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015543 +name: obsolete lactose/glucose efflux transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2] +comment: This term was made obsolete because it represents two molecular functions. +synonym: "lactose/glucose efflux transporter activity" EXACT [] +is_obsolete: true +consider: GO:0015155 + +[Term] +id: GO:0015544 +name: phenyl propionate uniporter activity +namespace: molecular_function +def: "Enables the transfer of phenyl propionate from one side of a membrane to the other." [GOC:mtg_transport, TC:2.A.1.27.1] +synonym: "phenyl propionate permease activity" RELATED [] +is_a: GO:0015292 ! uniporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity +is_a: GO:0015552 ! propionate transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015545 +name: bicyclomycin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:091191028X] +synonym: "bicyclomycin transporter activity" RELATED [] +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015546 +name: sulfathiazole transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group." [GOC:curators] +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] +synonym: "sulphathiazole transporter activity" EXACT [] +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015547 +name: nalidixic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] +synonym: "nalidixic acid transporter activity" RELATED [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0015548 +name: organomercurial transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] +synonym: "organomercurial transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015549 +name: carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators] +synonym: "carbonyl cyanide m-chlorophenylhydrazone transporter activity" RELATED [] +synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] +synonym: "CCCP transporter activity" EXACT [] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0015550 +name: galacturonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015551 +name: 3-hydroxyphenyl propanoate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other." [GOC:ai] +synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015552 +name: propionate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015636 ! short-chain fatty acid transmembrane transporter activity + +[Term] +id: GO:0015553 +name: xanthosine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732] +is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity + +[Term] +id: GO:0015554 +name: tartrate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] +is_a: GO:1901702 ! salt transmembrane transporter activity + +[Term] +id: GO:0015556 +name: C4-dicarboxylate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other." [GOC:krc] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0015558 +name: secondary active p-aminobenzoyl-glutamate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015569 +def: "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] +synonym: "p-aminobenzoyl-glutamate transmembrane transporter activity" NARROW [] +synonym: "p-aminobenzoyl-glutamate transporter activity" RELATED [] +synonym: "p-aminobenzoyl-glutamate uptake permease activity" RELATED [] +synonym: "p-aminobenzoyl-glutamate uptake transmembrane transporter activity" RELATED [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0071916 ! dipeptide transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0015560 +name: obsolete L-idonate/D-gluconate:hydrogen symporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" EXACT [] +synonym: "L-idonate/D-gluconate:proton symporter" EXACT [] +is_obsolete: true +consider: GO:0015128 +consider: GO:0015295 +consider: GO:0015568 + +[Term] +id: GO:0015561 +name: rhamnose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6] +synonym: "rhamnose:hydrogen symporter activity" EXACT [] +xref: TC:2.A.7.6 +is_a: GO:0009679 ! hexose:proton symporter activity +is_a: GO:0015153 ! rhamnose transmembrane transporter activity + +[Term] +id: GO:0015562 +name: efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "efflux permease activity" EXACT [] +synonym: "efflux transporter activity" EXACT [GOC:cjm] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015565 +name: threonine efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "threonine efflux permease activity" EXACT [] +synonym: "threonine export protein" RELATED [] +synonym: "threonine export transporter activity" EXACT [] +is_a: GO:0015195 ! L-threonine transmembrane transporter activity +is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity + +[Term] +id: GO:0015566 +name: acriflavine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015555 +def: "Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842] +synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb] +synonym: "acriflavin transporter activity" RELATED [GOC:dph, GOC:tb] +synonym: "acriflavine transporter activity" RELATED [] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity +is_a: GO:1901702 ! salt transmembrane transporter activity + +[Term] +id: GO:0015567 +name: alkane transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015568 +name: L-idonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] +synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0015571 +name: N-acetylgalactosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015590 +def: "Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "N-acetylgalactosamine permease activity" EXACT [] +is_a: GO:0019196 ! galactosamine transmembrane transporter activity + +[Term] +id: GO:0015572 +name: N-acetylglucosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015580 +def: "Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] +synonym: "N-Acetyl-D-glucosamine permease" RELATED [] +synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] +synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] +synonym: "N-acetylglucosamine permease activity" RELATED [] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015573 +name: beta-glucoside transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015582 +def: "Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] +synonym: "beta-glucoside permease activity" EXACT [] +is_a: GO:0042947 ! glucoside transmembrane transporter activity + +[Term] +id: GO:0015574 +name: trehalose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015584 +def: "Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "trehalose permease activity" EXACT [] +xref: RHEA:17629 +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0015575 +name: mannitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015586 +def: "Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "mannitol permease activity" EXACT [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015576 +name: sorbitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015587 +def: "Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] +synonym: "glucitol permease activity" EXACT [] +synonym: "glucitol transporter activity" EXACT [] +synonym: "sorbitol permease activity" EXACT [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0015577 +name: galactitol transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015588 +def: "Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "galactitol permease activity" EXACT [] +xref: RHEA:33143 +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity + +[Term] +id: GO:0015578 +name: mannose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015589 +def: "Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "mannose permease activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015583 +name: obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it arbitrarily groups three substrates. +synonym: "beta-glucoside [arbutin-salicin-cellobiose] permease activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015591 +name: D-ribose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0015592 +name: methylgalactoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:mtg_transport, ISBN:0815340729] +synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015593 +name: allose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0015594 +name: ABC-type putrescine transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)." [EC:7.6.2.11] +synonym: "ATPase-coupled putrescine transmembrane transporter activity" RELATED [] +synonym: "putrescine porter activity" BROAD [] +synonym: "putrescine-importing ATPase activity" NARROW [] +xref: EC:7.6.2.16 +xref: RHEA:29995 +is_a: GO:0015417 ! ABC-type polyamine transporter activity +is_a: GO:0015489 ! putrescine transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015596 +name: obsolete glycine betaine/proline porter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "glycine betaine/proline porter activity" EXACT [] +is_obsolete: true +consider: GO:0015187 +consider: GO:0015193 +consider: GO:0015199 +consider: GO:0015418 + +[Term] +id: GO:0015597 +name: obsolete histidine/arginine/lysine/ornithine porter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "histidine/arginine/lysine/ornithine porter activity" EXACT [] +is_obsolete: true +consider: GO:0000064 +consider: GO:0005290 +consider: GO:0015189 +consider: GO:0015426 +consider: GO:0061459 + +[Term] +id: GO:0015599 +name: ATPase-coupled L-glutamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)." [EC:7.4.2.1] +synonym: "ATPase-coupled glutamine transmembrane transporter activity" BROAD [] +synonym: "glutamine porter activity" BROAD [] +synonym: "glutamine-importing ATPase activity" RELATED [] +xref: EC:7.4.2.1 +xref: MetaCyc:ABC-12-RXN +is_a: GO:0015186 ! L-glutamine transmembrane transporter activity +is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0015600 +name: obsolete glutamate/aspartate porter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "glutamate/aspartate porter activity" EXACT [] +is_obsolete: true +consider: GO:0005313 +consider: GO:0015183 +consider: GO:0015426 + +[Term] +id: GO:0015601 +name: obsolete cystine/diaminopimelate porter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "cystine/diaminopimelate porter activity" EXACT [] +is_obsolete: true +consider: GO:0015184 +consider: GO:0015426 +consider: GO:0015626 + +[Term] +id: GO:0015602 +name: obsolete leucine/isoleucine/valine porter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "leucine/isoleucine/valine porter activity" EXACT [] +is_obsolete: true +consider: GO:0005304 +consider: GO:0015188 +consider: GO:0015190 +consider: GO:0015425 + +[Term] +id: GO:0015603 +name: iron chelate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [PMID:17660286] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015605 +name: organophosphate ester transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015606 +name: spermidine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015203 ! polyamine transmembrane transporter activity + +[Term] +id: GO:0015607 +name: ABC-type fatty-acyl-CoA transporter activity +namespace: molecular_function +def: "Catalysis of the reaction ATP + H(2)O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [RHEA:15181] +synonym: "ABC-type fatty-acyl-CoA transporter" EXACT [] +synonym: "ATPase-coupled fatty-acyl-CoA transmembrane transporter activity" RELATED [] +synonym: "fatty acyl CoA transporter activity" RELATED [] +synonym: "fatty-acyl-CoA transmembrane transporter activity" BROAD [] +synonym: "fatty-acyl-CoA-transporting ATPase" RELATED [EC:7.6.2.4] +xref: EC:7.6.2.4 +xref: RHEA:15181 +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0015608 +name: carbohydrate-importing ABC transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)." [GOC:ai] +synonym: "carbohydrate uptake transporter activity" EXACT [] +synonym: "carbohydrate-importing ATPase activity" BROAD [] +synonym: "sugar transporter" NARROW [] +xref: TC:3.A.1.1.1 +is_a: GO:0043211 ! ABC-type carbohydrate transporter activity + +[Term] +id: GO:0015611 +name: ABC-type D-ribose transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [RHEA:29903] +synonym: "D-ribose porter activity" BROAD [] +synonym: "D-ribose-importing ATPase activity" RELATED [] +xref: EC:7.5.2.8 +xref: MetaCyc:ABC-28-RXN +xref: RHEA:29903 +is_a: GO:0015407 ! ABC-type monosaccharide transporter activity +is_a: GO:0015591 ! D-ribose transmembrane transporter activity + +[Term] +id: GO:0015612 +name: ABC-type L-arabinose transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [RHEA:30007] +synonym: "L-arabinose porter activity" EXACT [] +synonym: "L-arabinose-importing ATPase activity" NARROW [] +xref: EC:7.5.2.12 +xref: EC:7.5.2.13 +xref: MetaCyc:ABC-2-RXN +xref: RHEA:30007 +is_a: GO:0015147 ! L-arabinose transmembrane transporter activity +is_a: GO:0015407 ! ABC-type monosaccharide transporter activity + +[Term] +id: GO:0015613 +name: obsolete galactose/glucose (methylgalactoside) porter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a multifunctional gene product. +synonym: "galactose/glucose (methylgalactoside) porter activity" EXACT [] +is_obsolete: true +consider: GO:0005354 +consider: GO:0005355 +consider: GO:0015291 +consider: GO:0015592 + +[Term] +id: GO:0015614 +name: ABC-type D-xylose transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)." [RHEA:29899] +synonym: "ATPase-coupled D-xylose transmembrane transporter activity" RELATED [] +synonym: "D-xylose porter activity" BROAD [] +synonym: "D-xylose-importing ATPase activity" RELATED [] +xref: EC:7.5.2.10 +xref: RHEA:29899 +is_a: GO:0015148 ! D-xylose transmembrane transporter activity +is_a: GO:0015407 ! ABC-type monosaccharide transporter activity + +[Term] +id: GO:0015615 +name: D-allose-importing ATPase activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)." [GOC:curators] +synonym: "D-allose porter activity" BROAD [] +is_a: GO:0015593 ! allose transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0015616 +name: DNA translocase activity +namespace: molecular_function +def: "Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis." [GOC:mah, PMID:16428451, PMID:17631491] +comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0015617 +name: obsolete pilin/fimbrilin exporter activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "pilin/fimbrilin exporter activity" EXACT [] +is_obsolete: true +consider: GO:0015462 + +[Term] +id: GO:0015620 +name: ferric-enterobactin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015343 ! siderophore transmembrane transporter activity + +[Term] +id: GO:0015621 +name: ferric triacetylfusarinine C transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015624 +name: ABC-type ferric-enterobactin transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [RHEA:58492] +synonym: "ATP-dependent ferric-enterobactin transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled ferric-enterobactin transmembrane transporter activity" RELATED [] +synonym: "ferric-enterobactin ABC transporter" EXACT [] +synonym: "ferric-enterobactin porter activity" BROAD [] +synonym: "ferric-enterobactin-transporting ATPase activity" RELATED [] +xref: EC:7.2.2.17 +xref: MetaCyc:ABC-10-RXN +xref: RHEA:58492 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015625 +name: ABC-type ferric hydroxamate transporter activity +namespace: molecular_function +alt_id: GO:0015409 +alt_id: GO:0015622 +alt_id: GO:0015623 +alt_id: GO:0102026 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [PMID:1551849] +synonym: "ATP-dependent ferric-hydroxamate transmembrane transporter activity" EXACT [] +synonym: "ATP-dependent iron-chelate transporter activity" BROAD [] +synonym: "ATPase-coupled ferric-hydroxamate transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled iron-chelate transporter activity" BROAD [] +synonym: "ferric-hydroxamate ABC transporter" NARROW [] +synonym: "ferric-hydroxamate porter activity" BROAD [] +synonym: "ferric-hydroxamate transmembrane transporter activity" BROAD [] +synonym: "ferric-hydroxamate-transporting ATPase activity" EXACT [] +synonym: "iron-chelate-transporting ATPase activity" BROAD [] +xref: EC:7.2.2.16 +xref: MetaCyc:3.6.3.34-RXN +xref: MetaCyc:ABC-11-RXN +xref: MetaCyc:ABC-9-RXN +is_a: GO:0015603 ! iron chelate transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015626 +name: L-diaminopimelate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "cystine/diaminopimelate porter activity" NARROW [] +synonym: "L-diaminopimelate transporter activity" BROAD [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0015627 +name: type II protein secretion system complex +namespace: cellular_component +def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] +comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. +synonym: "general secretion pathway-associated complex" RELATED [] +synonym: "main terminal branch" EXACT [] +synonym: "MTB" EXACT [] +synonym: "Sec-dependent secretion system-associated complex" RELATED [] +synonym: "T2SS-associated complexes" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0015628 +name: protein secretion by the type II secretion system +namespace: biological_process +def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. +synonym: "protein secretion by the general secretion pathway" RELATED [] +synonym: "protein secretion by the general secretory pathway" RELATED [] +synonym: "protein secretion by the T2S" EXACT [] +synonym: "protein secretion by the T2SS" EXACT [] +synonym: "protein secretion by the type II protein secretion system" EXACT [] +synonym: "type II protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0098776 ! protein transport across the cell outer membrane + +[Term] +id: GO:0015629 +name: actin cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] +subset: goslim_aspergillus +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0015630 +name: microtubule cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] +subset: goslim_aspergillus +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0015631 +name: tubulin binding +namespace: molecular_function +def: "Binding to monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0015633 +name: ABC-type zinc transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [RHEA:29795] +synonym: "ATP-dependent zinc transmembrane transporter activity" BROAD [] +synonym: "ATPase-coupled zinc transmembrane transporter activity" BROAD [] +synonym: "zinc porter activity" RELATED [] +synonym: "zinc transporting ATPase activity" BROAD [] +synonym: "zinc-transporting ATPase activity" BROAD [] +xref: EC:7.2.2.20 +xref: RHEA:29795 +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0015634 +name: obsolete lipopolysaccharide exporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was obsoleted because export is a process, not a function. +synonym: "LPS exporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0015636 +name: short-chain fatty acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015635 +def: "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:mah] +synonym: "short-chain fatty acid transporter activity" RELATED [] +synonym: "short-chain fatty acid uptake transporter activity" RELATED [] +is_a: GO:0015245 ! fatty acid transmembrane transporter activity + +[Term] +id: GO:0015638 +name: microcin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a microcin from one side of a membrane to the other." [GOC:mah] +synonym: "microcin uptake permease activity" EXACT [] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0015640 +name: peptidoglycan peptide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] +synonym: "murein peptide transporter activity" EXACT [] +synonym: "muropeptide transporter activity" EXACT [] +is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity + +[Term] +id: GO:0015641 +name: obsolete lipoprotein toxin +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "lipoprotein toxin" EXACT [] +is_obsolete: true +consider: GO:0090729 + +[Term] +id: GO:0015642 +name: obsolete bacteriolytic toxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl] +comment: This term was made obsolete because it represents a class of gene products and not a molecular function. +synonym: "bacteriolytic toxin activity" EXACT [] +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015643 +name: toxic substance binding +namespace: molecular_function +def: "Binding to a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr] +synonym: "antitoxin activity" RELATED [] +synonym: "lipoprotein antitoxin" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0015644 +name: obsolete lipoprotein antitoxin +namespace: molecular_function +def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl] +comment: This term was made obsolete because it does not represent a function distinct from its parent term. +synonym: "lipoprotein antitoxin" EXACT [] +is_obsolete: true +replaced_by: GO:0015643 + +[Term] +id: GO:0015645 +name: fatty acid ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [GOC:cjk, GOC:mah] +synonym: "fatty acid CoA ligase activity" RELATED [] +synonym: "fatty acyl-coenzyme A synthetase activity" RELATED [] +synonym: "fatty-acid ligase activity" EXACT [] +is_a: GO:0016878 ! acid-thiol ligase activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0015647 +name: peptidoglycan transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other." [GOC:ai] +synonym: "murein transporter activity" EXACT [] +is_a: GO:0022884 ! macromolecule transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015648 +name: lipid-linked peptidoglycan transporter activity +namespace: molecular_function +def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah] +synonym: "lipid-linked murein transporter activity" EXACT [] +is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity + +[Term] +id: GO:0015649 +name: 2-keto-3-deoxygluconate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] +synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015145 ! monosaccharide transmembrane transporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0015650 +name: lactate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] +synonym: "lactate permease" BROAD [] +synonym: "lactate:hydrogen porter activity" EXACT [] +synonym: "lactate:hydrogen symporter activity" EXACT [] +synonym: "lactate:proton porter activity" EXACT [] +is_a: GO:0015129 ! lactate transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0015651 +name: quaternary ammonium group transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015202 +def: "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732] +synonym: "quaternary amine transmembrane transporter activity" EXACT [] +synonym: "quaternary ammonium compound transporter activity" EXACT [] +is_a: GO:0015101 ! organic cation transmembrane transporter activity + +[Term] +id: GO:0015652 +name: quaternary ammonium group:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] +synonym: "quaternary ammonium group:hydrogen symporter activity" EXACT [] +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity + +[Term] +id: GO:0015653 +name: glycine betaine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] +synonym: "glycine betaine:hydrogen symporter activity" EXACT [] +is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity +is_a: GO:0015652 ! quaternary ammonium group:proton symporter activity + +[Term] +id: GO:0015654 +name: tellurite transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015118 +def: "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [GOC:ai] +synonym: "tellurite uptake transmembrane transporter activity" RELATED [] +synonym: "tellurite-resistance uptake permease activity" RELATED [] +synonym: "tellurite-resistance uptake transmembrane transporter activity" RELATED [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0015655 +name: alanine:sodium symporter activity +namespace: molecular_function +alt_id: GO:0044670 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] +synonym: "sodium:alanine symporter activity" EXACT [] +xref: RHEA:29283 +is_a: GO:0005283 ! amino acid:sodium symporter activity +is_a: GO:0022858 ! alanine transmembrane transporter activity + +[Term] +id: GO:0015657 +name: branched-chain amino acid:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] +is_a: GO:0005283 ! amino acid:sodium symporter activity +is_a: GO:0015297 ! antiporter activity +is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity + +[Term] +id: GO:0015658 +name: branched-chain amino acid transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901240 +def: "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729] +synonym: "branched-chain aliphatic amino acid transmembrane transporter activity" EXACT [GOC:bf] +synonym: "branched-chain aliphatic amino acid transporter activity" EXACT [] +synonym: "leucine/valine/isoleucine permease activity" RELATED [] +synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] +xref: Reactome:R-HSA-9672770 "SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix" +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0015660 +name: formate efflux transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015509 +def: "Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "formate efflux permease activity" RELATED [] +is_a: GO:0015499 ! formate transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0015661 +name: L-lysine efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "L-lysine exporter activity" EXACT [] +synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] +is_a: GO:0015189 ! L-lysine transmembrane transporter activity +is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity + +[Term] +id: GO:0015662 +name: P-type ion transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] +synonym: "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" EXACT [] +synonym: "ion transmembrane transporter activity, phosphorylative mechanism" RELATED [] +synonym: "P-type ATPase activity" EXACT [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] +xref: Reactome:R-HSA-429157 "ABCC4 accumulation of dense granule contents" +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140358 ! P-type transmembrane transporter activity + +[Term] +id: GO:0015663 +name: nicotinamide mononucleotide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015664 +def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544] +synonym: "nicotinamide mononucleotide permease activity" RELATED [] +synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0015665 +name: alcohol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732] +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0015666 +name: restriction endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] +synonym: "restriction endonuclease activity" EXACT [] +synonym: "restriction enzyme activity" EXACT [] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0015667 +name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] +synonym: "DNA[cytosine-N4]methyltransferase activity" RELATED [EC:2.1.1.113] +synonym: "m4C-forming MTase activity" RELATED [EC:2.1.1.113] +synonym: "modification methylase activity" RELATED [EC:2.1.1.113] +synonym: "N(4)-cytosine-specific DNA methylase activity" RELATED [EC:2.1.1.113] +synonym: "N4-cytosine-specific DNA methylase activity" RELATED [EC:2.1.1.113] +synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] +synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" RELATED [EC:2.1.1.113] +synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" RELATED [EC:2.1.1.113] +xref: EC:2.1.1.113 +xref: MetaCyc:2.1.1.113-RXN +xref: RHEA:16857 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0009008 ! DNA-methyltransferase activity + +[Term] +id: GO:0015668 +name: type III site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] +synonym: "type III restriction enzyme activity" EXACT [] +xref: EC:3.1.21.5 +xref: MetaCyc:3.1.21.5-RXN +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0015669 +name: gas transport +namespace: biological_process +def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015670 +name: carbon dioxide transport +namespace: biological_process +def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015669 ! gas transport +is_a: GO:0019755 ! one-carbon compound transport + +[Term] +id: GO:0015671 +name: oxygen transport +namespace: biological_process +def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015669 ! gas transport + +[Term] +id: GO:0015673 +name: silver ion transport +namespace: biological_process +def: "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "silver transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015675 +name: nickel cation transport +namespace: biological_process +def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015676 +name: vanadium ion transport +namespace: biological_process +def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015677 +name: copper ion import +namespace: biological_process +def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] +synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006825 ! copper ion transport + +[Term] +id: GO:0015679 +name: plasma membrane copper ion transport +namespace: biological_process +def: "The directed movement of copper ions across the plasma membrane." [GOC:ai] +synonym: "plasma membrane copper transport" EXACT [] +is_a: GO:0035434 ! copper ion transmembrane transport + +[Term] +id: GO:0015680 +name: protein maturation by copper ion transfer +namespace: biological_process +def: "A process that contributes to the delivery of copper ions to a target protein." [GOC:ai] +synonym: "intracellular copper delivery" EXACT [] +synonym: "intracellular copper ion delivery" RELATED [] +synonym: "intracellular copper ion transport" BROAD [] +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0015685 +name: ferric-enterobactin import into cell +namespace: biological_process +def: "A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] +synonym: "ferric-enterobactin transport" BROAD [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0033212 ! iron import into cell +is_a: GO:1901678 ! iron coordination entity transport + +[Term] +id: GO:0015686 +name: ferric triacetylfusarinine C import into cell +namespace: biological_process +def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "ferric triacetylfusarinine C transport" BROAD [] +is_a: GO:0033214 ! siderophore-dependent iron import into cell +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015687 +name: ferric-hydroxamate import into cell +namespace: biological_process +def: "A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] +synonym: "ferric-hydroxamate transport" BROAD [] +is_a: GO:0033214 ! siderophore-dependent iron import into cell + +[Term] +id: GO:0015689 +name: molybdate ion transport +namespace: biological_process +def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015690 +name: aluminum cation transport +namespace: biological_process +def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "aluminium ion transport" EXACT [] +synonym: "aluminium transport" EXACT [] +synonym: "aluminum ion transport" RELATED [] +synonym: "aluminum transport" EXACT [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015691 +name: cadmium ion transport +namespace: biological_process +def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "cadmium transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport + +[Term] +id: GO:0015692 +name: lead ion transport +namespace: biological_process +def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015693 +name: magnesium ion transport +namespace: biological_process +def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "magnesium transport" RELATED [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0015694 +name: mercury ion transport +namespace: biological_process +def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "mercuric ion transport" NARROW [] +synonym: "mercury transport" EXACT [] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport +relationship: part_of GO:0050787 ! detoxification of mercury ion + +[Term] +id: GO:0015695 +name: organic cation transport +namespace: biological_process +def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015697 +name: quaternary ammonium group transport +namespace: biological_process +alt_id: GO:0015845 +def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732] +synonym: "quaternary amine transport" EXACT [] +synonym: "quaternary ammonium compound transport" EXACT [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015698 +name: inorganic anion transport +namespace: biological_process +def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] +is_a: GO:0006820 ! anion transport + +[Term] +id: GO:0015699 +name: antimonite transport +namespace: biological_process +def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015700 +name: arsenite transport +namespace: biological_process +def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015701 +name: bicarbonate transport +namespace: biological_process +def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015702 +name: chlorate transport +namespace: biological_process +def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015703 +name: chromate transport +namespace: biological_process +def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015704 +name: cyanate transport +namespace: biological_process +def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0006820 ! anion transport +is_a: GO:0019755 ! one-carbon compound transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015705 +name: iodide transport +namespace: biological_process +def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015706 +name: nitrate transport +namespace: biological_process +alt_id: GO:0006872 +alt_id: GO:0080055 +def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "low affinity nitrate transport" NARROW [] +synonym: "low-affinity nitrate transport" NARROW [] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015707 +name: nitrite transport +namespace: biological_process +def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015708 +name: silicic acid import across plasma membrane +namespace: biological_process +alt_id: GO:0051207 +alt_id: GO:1902067 +def: "The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, GOC:krc, PMID:16572174] +synonym: "silicate transport" BROAD [] +synonym: "silicic acid import" RELATED [] +synonym: "silicic acid transport" EXACT [] +synonym: "silicon uptake" RELATED [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098661 ! inorganic anion transmembrane transport +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0015709 +name: thiosulfate transport +namespace: biological_process +def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "thiosulphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015710 +name: tellurite transport +namespace: biological_process +def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0015711 +name: organic anion transport +namespace: biological_process +def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] +is_a: GO:0006820 ! anion transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015712 +name: hexose phosphate transport +namespace: biological_process +def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015713 +name: phosphoglycerate transmembrane transport +namespace: biological_process +def: "The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "phosphoglycerate transport" RELATED [] +is_a: GO:0042873 ! aldonate transmembrane transport + +[Term] +id: GO:0015714 +name: phosphoenolpyruvate transport +namespace: biological_process +def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015715 +name: nucleotide-sulfate transport +namespace: biological_process +def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "nucleotide-sulphate transport" EXACT [] +is_a: GO:0006862 ! nucleotide transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015716 +name: organic phosphonate transport +namespace: biological_process +alt_id: GO:0042916 +def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc] +synonym: "alkylphosphonate transport" NARROW [] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015717 +name: triose phosphate transport +namespace: biological_process +def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "aldotriose phosphate transport" EXACT [] +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015718 +name: monocarboxylic acid transport +namespace: biological_process +def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015719 +name: allantoate transport +namespace: biological_process +def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "allantoin/allantoate transport" BROAD [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0015720 +name: allantoin transport +namespace: biological_process +def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "allantoin transmembrane transport" EXACT [GOC:mah] +synonym: "allantoin/allantoate transport" BROAD [] +is_a: GO:0042886 ! amide transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015721 +name: bile acid and bile salt transport +namespace: biological_process +def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] +synonym: "bile acid transport" NARROW [] +synonym: "bile salt transport" NARROW [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015722 +name: canalicular bile acid transport +namespace: biological_process +def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] +is_a: GO:0015721 ! bile acid and bile salt transport +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0015723 +name: bilirubin transport +namespace: biological_process +def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015724 +name: formate transport +namespace: biological_process +def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015726 +name: L-idonate transmembrane transport +namespace: biological_process +def: "The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc] +synonym: "L-idonate transport" RELATED [] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0042873 ! aldonate transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0015727 +name: lactate transport +namespace: biological_process +def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015728 +name: mevalonate transport +namespace: biological_process +def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015729 +name: oxaloacetate transport +namespace: biological_process +def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015730 +name: propanoate transport +namespace: biological_process +def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "propionate transport" EXACT [] +is_a: GO:0015908 ! fatty acid transport +is_a: GO:0015912 ! short-chain fatty acid transport + +[Term] +id: GO:0015731 +name: 3-hydroxyphenyl propanoate transport +namespace: biological_process +def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "3-hydroxyphenyl propionate transport" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015732 +name: prostaglandin transport +namespace: biological_process +def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:0015733 +name: shikimate transmembrane transport +namespace: biological_process +def: "The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "shikimate transport" RELATED [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0015734 +name: taurine transport +namespace: biological_process +def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015849 ! organic acid transport +is_a: GO:0042918 ! alkanesulfonate transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015735 +name: uronic acid transmembrane transport +namespace: biological_process +def: "The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "uronic acid transport" RELATED [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015736 +name: hexuronate transmembrane transport +namespace: biological_process +def: "The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732] +synonym: "hexuronate transport" RELATED [] +is_a: GO:0015735 ! uronic acid transmembrane transport + +[Term] +id: GO:0015737 +name: galacturonate transmembrane transport +namespace: biological_process +def: "The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "galacturonate transport" RELATED [] +is_a: GO:0015736 ! hexuronate transmembrane transport + +[Term] +id: GO:0015738 +name: glucuronate transmembrane transport +namespace: biological_process +def: "The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "glucuronate transport" RELATED [] +is_a: GO:0015736 ! hexuronate transmembrane transport + +[Term] +id: GO:0015739 +name: sialic acid transport +namespace: biological_process +def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015740 +name: C4-dicarboxylate transport +namespace: biological_process +def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah] +is_a: GO:0006835 ! dicarboxylic acid transport + +[Term] +id: GO:0015741 +name: fumarate transport +namespace: biological_process +def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015742 +name: alpha-ketoglutarate transport +namespace: biological_process +def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "2-oxoglutarate transport" EXACT [] +synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015743 +name: malate transport +namespace: biological_process +def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015744 +name: succinate transport +namespace: biological_process +def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015745 +name: tartrate transmembrane transport +namespace: biological_process +def: "The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] +synonym: "tartrate transport" RELATED [] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0042869 ! aldarate transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0015746 +name: citrate transport +namespace: biological_process +def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0006842 ! tricarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015747 +name: urate transport +namespace: biological_process +def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +synonym: "urate transmembrane transport" EXACT [GOC:mah] +synonym: "uric acid transport" EXACT [] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015748 +name: organophosphate ester transport +namespace: biological_process +def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015749 +name: monosaccharide transmembrane transport +namespace: biological_process +alt_id: GO:1905950 +def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] +synonym: "monosaccharide transport" RELATED [] +is_a: GO:0034219 ! carbohydrate transmembrane transport + +[Term] +id: GO:0015750 +name: pentose transmembrane transport +namespace: biological_process +def: "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai] +synonym: "pentose transport" RELATED [] +is_a: GO:0015749 ! monosaccharide transmembrane transport + +[Term] +id: GO:0015751 +name: arabinose transmembrane transport +namespace: biological_process +def: "The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] +synonym: "arabinose transport" RELATED [] +is_a: GO:0015750 ! pentose transmembrane transport + +[Term] +id: GO:0015752 +name: D-ribose transmembrane transport +namespace: biological_process +def: "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai] +synonym: "D-ribose transport" RELATED [] +is_a: GO:0015750 ! pentose transmembrane transport + +[Term] +id: GO:0015753 +name: D-xylose transmembrane transport +namespace: biological_process +def: "The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai] +synonym: "D-xylose transport" RELATED [] +is_a: GO:0015750 ! pentose transmembrane transport + +[Term] +id: GO:0015754 +name: allose transmembrane transport +namespace: biological_process +def: "The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai] +synonym: "allose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015755 +name: fructose transmembrane transport +namespace: biological_process +def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai] +synonym: "fructose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015756 +name: fucose transmembrane transport +namespace: biological_process +def: "The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai] +synonym: "fucose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015757 +name: galactose transmembrane transport +namespace: biological_process +def: "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai] +synonym: "galactose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015759 +name: beta-glucoside transport +namespace: biological_process +def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] +is_a: GO:0042946 ! glucoside transport + +[Term] +id: GO:0015760 +name: glucose-6-phosphate transport +namespace: biological_process +def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] +is_a: GO:0015712 ! hexose phosphate transport + +[Term] +id: GO:0015761 +name: mannose transmembrane transport +namespace: biological_process +def: "The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai] +synonym: "mannose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015762 +name: rhamnose transmembrane transport +namespace: biological_process +def: "The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai] +synonym: "rhamnose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:0015763 +name: N-acetylgalactosamine transport +namespace: biological_process +def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai] +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015764 +name: N-acetylglucosamine transport +namespace: biological_process +def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015765 +name: methylgalactoside transport +namespace: biological_process +def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [GOC:curators] +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0015766 +name: disaccharide transport +namespace: biological_process +def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:0015767 +name: lactose transport +namespace: biological_process +def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015768 +name: maltose transport +namespace: biological_process +def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015769 +name: melibiose transport +namespace: biological_process +def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015770 +name: sucrose transport +namespace: biological_process +def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015771 +name: trehalose transport +namespace: biological_process +def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0015772 +name: oligosaccharide transport +namespace: biological_process +def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015773 +name: raffinose transport +namespace: biological_process +def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:0015774 +name: polysaccharide transport +namespace: biological_process +def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +relationship: part_of GO:0033037 ! polysaccharide localization + +[Term] +id: GO:0015775 +name: beta-glucan transport +namespace: biological_process +def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015776 +name: capsular polysaccharide transport +namespace: biological_process +def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] +synonym: "capsular-polysaccharide transport" EXACT [] +synonym: "capsule polysaccharide transport" EXACT [] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0015777 +name: teichoic acid transport +namespace: biological_process +def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai] +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015778 +name: hexuronide transport +namespace: biological_process +def: "The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0015779 +name: glucuronoside transport +namespace: biological_process +def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai] +synonym: "glucuronide transport" EXACT [] +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0015780 +name: nucleotide-sugar transmembrane transport +namespace: biological_process +def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] +synonym: "nucleotide-sugar transport" RELATED [] +is_a: GO:0015931 ! nucleobase-containing compound transport +is_a: GO:0055085 ! transmembrane transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015782 +name: CMP-N-acetylneuraminate transmembrane transport +namespace: biological_process +def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "CMP-N-acetylneuraminate transport" RELATED [] +synonym: "CMP-sialic acid transport" BROAD [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015783 +name: GDP-fucose transmembrane transport +namespace: biological_process +def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-fucose transport" RELATED [] +is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport + +[Term] +id: GO:0015786 +name: UDP-glucose transmembrane transport +namespace: biological_process +def: "The process in which UDP-glucose is transported across a membrane." [GOC:ai] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015787 +name: UDP-glucuronic acid transmembrane transport +namespace: biological_process +def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-glucuronic acid transport" RELATED [] +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015789 +name: UDP-N-acetylgalactosamine transmembrane transport +namespace: biological_process +def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylgalactosamine transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015790 +name: UDP-xylose transmembrane transport +namespace: biological_process +def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-xylose transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015791 +name: polyol transport +namespace: biological_process +def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015792 +name: arabinitol transmembrane transport +namespace: biological_process +def: "The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] +synonym: "arabinitol transport" RELATED [] +synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb] +is_a: GO:0015791 ! polyol transport +is_a: GO:0034219 ! carbohydrate transmembrane transport + +[Term] +id: GO:0015793 +name: glycerol transport +namespace: biological_process +def: "The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015794 +name: glycerol-3-phosphate transmembrane transport +namespace: biological_process +def: "The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] +synonym: "glycerol-3-phosphate transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015795 +name: sorbitol transport +namespace: biological_process +def: "The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] +synonym: "glucitol transport" EXACT [] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015796 +name: galactitol transport +namespace: biological_process +def: "The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015797 +name: mannitol transport +namespace: biological_process +def: "The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015798 +name: myo-inositol transport +namespace: biological_process +def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] +synonym: "vitamin Bh transport" EXACT [] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015799 +name: propanediol transport +namespace: biological_process +def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com] +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0015800 +name: acidic amino acid transport +namespace: biological_process +def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015801 +name: aromatic amino acid transport +namespace: biological_process +def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015802 +name: basic amino acid transport +namespace: biological_process +def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015803 +name: branched-chain amino acid transport +namespace: biological_process +alt_id: GO:1900755 +def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [GOC:ai, GOC:bf] +synonym: "branched-chain aliphatic amino acid transport" EXACT [] +synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl] +synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015804 +name: neutral amino acid transport +namespace: biological_process +def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015805 +name: S-adenosyl-L-methionine transport +namespace: biological_process +def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "S-adenosyl methionine transport" EXACT [] +synonym: "S-adenosylmethionine transport" EXACT [] +synonym: "SAM transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015806 +name: S-methylmethionine transport +namespace: biological_process +def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015807 +name: L-amino acid transport +namespace: biological_process +def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015808 +name: L-alanine transport +namespace: biological_process +def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032328 ! alanine transport + +[Term] +id: GO:0015810 +name: aspartate transmembrane transport +namespace: biological_process +def: "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators, ISBN:0198506732] +synonym: "aspartate transport" BROAD [] +synonym: "mitochondrial aspartate/glutamate transport" RELATED [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015811 +name: L-cystine transport +namespace: biological_process +def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0000101 ! sulfur amino acid transport +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0015812 +name: gamma-aminobutyric acid transport +namespace: biological_process +def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] +comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. +synonym: "4-aminobutanoate transport" EXACT [] +synonym: "4-aminobutyrate transport" EXACT [] +synonym: "GABA transport" EXACT [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015813 +name: L-glutamate transmembrane transport +namespace: biological_process +alt_id: GO:0089711 +def: "The directed movement of L-glutamate across a membrane." [PMID:21307582] +synonym: "L-glutamate transport" BROAD [] +synonym: "mitochondrial aspartate/glutamate transport" RELATED [] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0015814 +name: p-aminobenzoyl-glutamate transport +namespace: biological_process +def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0042938 ! dipeptide transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0015816 +name: glycine transport +namespace: biological_process +def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015817 +name: histidine transport +namespace: biological_process +def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-histidine transport" NARROW [] +is_a: GO:0015802 ! basic amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015818 +name: isoleucine transport +namespace: biological_process +def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-isoleucine transport" NARROW [] +is_a: GO:0015803 ! branched-chain amino acid transport +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015819 +name: lysine transport +namespace: biological_process +alt_id: GO:0034226 +alt_id: GO:0061461 +def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-lysine import" NARROW [] +synonym: "L-lysine transport" NARROW [] +synonym: "lysine import" NARROW [] +synonym: "lysine uptake" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0015802 ! basic amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015820 +name: leucine transport +namespace: biological_process +def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-leucine transport" NARROW [] +is_a: GO:0015803 ! branched-chain amino acid transport +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015821 +name: methionine transport +namespace: biological_process +def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-methionine transport" NARROW [] +is_a: GO:0000101 ! sulfur amino acid transport +is_a: GO:0006812 ! cation transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015822 +name: ornithine transport +namespace: biological_process +def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-ornithine transport" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0006865 ! amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015823 +name: phenylalanine transport +namespace: biological_process +def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-phenylalanine transport" NARROW [] +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015824 +name: proline transport +namespace: biological_process +def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-proline transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015825 +name: L-serine transport +namespace: biological_process +alt_id: GO:0090479 +def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "L-serine import" NARROW [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032329 ! serine transport + +[Term] +id: GO:0015826 +name: threonine transport +namespace: biological_process +def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-threonine transport" NARROW [] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015827 +name: tryptophan transport +namespace: biological_process +def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-tryptophan transport" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0015801 ! aromatic amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0015828 +name: tyrosine transport +namespace: biological_process +def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-tyrosine transport" NARROW [] +is_a: GO:0015801 ! aromatic amino acid transport + +[Term] +id: GO:0015829 +name: valine transport +namespace: biological_process +def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "L-valine transport" NARROW [] +is_a: GO:0015803 ! branched-chain amino acid transport +is_a: GO:0015804 ! neutral amino acid transport + +[Term] +id: GO:0015830 +name: diaminopimelate transport +namespace: biological_process +def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0015832 +name: obsolete holin +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "holin" EXACT [] +is_obsolete: true +consider: GO:0019835 + +[Term] +id: GO:0015833 +name: peptide transport +namespace: biological_process +def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +is_a: GO:0042886 ! amide transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015834 +name: peptidoglycan-associated peptide transport +namespace: biological_process +def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] +synonym: "murein peptide transport" EXACT [] +synonym: "muropeptide transport" EXACT [] +synonym: "peptidoglycan peptide transport" EXACT [GOC:mah] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0015835 +name: peptidoglycan transport +namespace: biological_process +def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +synonym: "murein transport" EXACT [] +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015836 +name: lipid-linked peptidoglycan transport +namespace: biological_process +def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "lipid-linked murein transport" EXACT [] +is_a: GO:0015835 ! peptidoglycan transport + +[Term] +id: GO:0015837 +name: amine transport +namespace: biological_process +def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] +subset: goslim_pir +synonym: "amine/polyamine transport" RELATED [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015838 +name: amino-acid betaine transport +namespace: biological_process +def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "betaine transport" EXACT [] +is_a: GO:0015697 ! quaternary ammonium group transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0015839 +name: cadaverine transport +namespace: biological_process +def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015840 +name: urea transport +namespace: biological_process +def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732] +is_a: GO:0019755 ! one-carbon compound transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0015841 +name: chromaffin granule amine transport +namespace: biological_process +def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah] +is_a: GO:0015837 ! amine transport + +[Term] +id: GO:0015842 +name: aminergic neurotransmitter loading into synaptic vesicle +namespace: biological_process +def: "The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:ai] +is_a: GO:0015837 ! amine transport +is_a: GO:0098700 ! neurotransmitter loading into synaptic vesicle + +[Term] +id: GO:0015843 +name: methylammonium transport +namespace: biological_process +def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0015837 ! amine transport +is_a: GO:0019755 ! one-carbon compound transport + +[Term] +id: GO:0015844 +name: monoamine transport +namespace: biological_process +alt_id: GO:0015873 +def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015846 +name: polyamine transport +namespace: biological_process +def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015847 +name: putrescine transport +namespace: biological_process +def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0015848 +name: spermidine transport +namespace: biological_process +def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015846 ! polyamine transport + +[Term] +id: GO:0015849 +name: organic acid transport +namespace: biological_process +def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] +subset: goslim_pir +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015850 +name: organic hydroxy compound transport +namespace: biological_process +def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [GOC:ai] +synonym: "organic alcohol transport" EXACT [] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015851 +name: nucleobase transport +namespace: biological_process +def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] +synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015853 +name: adenine transport +namespace: biological_process +def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] +synonym: "adenine transmembrane transport" EXACT [GOC:mah] +is_a: GO:0006863 ! purine nucleobase transport + +[Term] +id: GO:0015854 +name: guanine transport +namespace: biological_process +def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0006863 ! purine nucleobase transport + +[Term] +id: GO:0015855 +name: pyrimidine nucleobase transport +namespace: biological_process +def: "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah] +synonym: "pyrimidine base transport" EXACT [GOC:go_curators] +synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah] +synonym: "pyrimidine transport" RELATED [] +is_a: GO:0015851 ! nucleobase transport + +[Term] +id: GO:0015856 +name: cytosine transport +namespace: biological_process +def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +synonym: "cytosine transmembrane transport" EXACT [GOC:mah] +is_a: GO:0015855 ! pyrimidine nucleobase transport + +[Term] +id: GO:0015857 +name: uracil transport +namespace: biological_process +def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0015855 ! pyrimidine nucleobase transport + +[Term] +id: GO:0015858 +name: nucleoside transport +namespace: biological_process +def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015931 ! nucleobase-containing compound transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015859 +name: intracellular nucleoside transport +namespace: biological_process +def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai] +is_a: GO:0015858 ! nucleoside transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0015860 +name: purine nucleoside transmembrane transport +namespace: biological_process +alt_id: GO:0035427 +def: "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar." [GOC:ai, GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "purine nucleoside membrane transport" EXACT [] +synonym: "purine nucleoside transport" BROAD [GOC:vw] +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:1901642 ! nucleoside transmembrane transport + +[Term] +id: GO:0015861 +name: cytidine transport +namespace: biological_process +def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0015862 +name: uridine transport +namespace: biological_process +def: "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0015863 +name: xanthosine transport +namespace: biological_process +def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0015864 +name: pyrimidine nucleoside transport +namespace: biological_process +def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0015865 +name: purine nucleotide transport +namespace: biological_process +def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0015866 +name: ADP transport +namespace: biological_process +def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0015867 +name: ATP transport +namespace: biological_process +def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0015868 +name: purine ribonucleotide transport +namespace: biological_process +def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] +is_a: GO:0015865 ! purine nucleotide transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015869 +name: protein-DNA complex transport +namespace: biological_process +def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "DNA-protein complex transport" EXACT [GOC:mah] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0015931 ! nucleobase-containing compound transport +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0015870 +name: acetylcholine transport +namespace: biological_process +def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:1901374 ! acetate ester transport + +[Term] +id: GO:0015871 +name: choline transport +namespace: biological_process +def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015872 +name: dopamine transport +namespace: biological_process +def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0015874 +name: norepinephrine transport +namespace: biological_process +def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] +synonym: "levarterenol transport" EXACT [] +synonym: "noradrenaline transport" EXACT [] +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0015875 +name: obsolete vitamin or cofactor transport +namespace: biological_process +def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "vitamin or cofactor transport" EXACT [] +is_obsolete: true +consider: GO:0051180 + +[Term] +id: GO:0015876 +name: acetyl-CoA transport +namespace: biological_process +def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015916 ! fatty-acyl-CoA transport + +[Term] +id: GO:0015877 +name: biopterin transport +namespace: biological_process +def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015878 +name: biotin transport +namespace: biological_process +def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] +synonym: "vitamin B7 transport" EXACT [] +synonym: "vitamin H transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0042886 ! amide transport +is_a: GO:0051180 ! vitamin transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015879 +name: carnitine transport +namespace: biological_process +def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] +synonym: "vitamin Bt transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015838 ! amino-acid betaine transport + +[Term] +id: GO:0015880 +name: coenzyme A transport +namespace: biological_process +def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0015881 +name: creatine transmembrane transport +namespace: biological_process +alt_id: GO:1902598 +def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "creatine transport" BROAD [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015882 +name: L-ascorbic acid transmembrane transport +namespace: biological_process +def: "The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:ai] +synonym: "L-ascorbate transport" EXACT [] +synonym: "L-ascorbic acid transport" RELATED [] +synonym: "vitamin C transport" EXACT [] +is_a: GO:0015749 ! monosaccharide transmembrane transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0015883 +name: FAD transport +namespace: biological_process +def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] +synonym: "flavin adenine dinucleotide transport" EXACT [] +synonym: "flavin-adenine dinucleotide transport" EXACT [] +is_a: GO:0006862 ! nucleotide transport +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0015884 +name: folic acid transport +namespace: biological_process +def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] +synonym: "folate transport" EXACT [] +synonym: "vitamin B9 transport" EXACT [] +synonym: "vitamin M transport" EXACT [] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0042886 ! amide transport +is_a: GO:0051180 ! vitamin transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0015885 +name: 5-formyltetrahydrofolate transport +namespace: biological_process +def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0015886 +name: heme transport +namespace: biological_process +def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "haem transport" EXACT [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:1901678 ! iron coordination entity transport + +[Term] +id: GO:0015887 +name: pantothenate transmembrane transport +namespace: biological_process +def: "The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "pantothenate membrane transport" EXACT [] +synonym: "pantothenate transport" EXACT [GOC:mah] +synonym: "vitamin B5 transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0042886 ! amide transport +is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015888 +name: thiamine transport +namespace: biological_process +def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] +synonym: "thiamin transport" EXACT [] +synonym: "vitamin B1 transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0051180 ! vitamin transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0015889 +name: cobalamin transport +namespace: biological_process +def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "vitamin B12 transport" EXACT [] +is_a: GO:0051180 ! vitamin transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015890 +name: nicotinamide mononucleotide transport +namespace: biological_process +def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [ISBN:0721662544] +synonym: "nicotinamide ribonucleotide transport" EXACT [] +is_a: GO:0006862 ! nucleotide transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015891 +name: siderophore transport +namespace: biological_process +alt_id: GO:0015892 +def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +synonym: "iron-siderochrome transport" NARROW [] +synonym: "iron-siderophore transport" EXACT [] +synonym: "siderochrome transport" NARROW [] +synonym: "siderophore-iron transport" EXACT [] +is_a: GO:1901678 ! iron coordination entity transport + +[Term] +id: GO:0015894 +name: acriflavine transport +namespace: biological_process +def: "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842] +synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb] +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0015895 +name: alkane transport +namespace: biological_process +def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015896 +name: nalidixic acid transport +namespace: biological_process +def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015897 +name: organomercurial transport +namespace: biological_process +def: "The process in which an organomercurial compound is transported across a membrane. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015898 +name: amiloride transport +namespace: biological_process +def: "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015899 +name: aminotriazole transport +namespace: biological_process +def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [GOC:curators] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015900 +name: benomyl transport +namespace: biological_process +def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [GOC:curators] +is_a: GO:0042886 ! amide transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0015901 +name: cycloheximide transport +namespace: biological_process +def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0015902 +name: carbonyl cyanide m-chlorophenylhydrazone transport +namespace: biological_process +def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [GOC:curators] +synonym: "CCCP transport" EXACT [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015903 +name: fluconazole transport +namespace: biological_process +def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [GOC:curators] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015904 +name: tetracycline transmembrane transport +namespace: biological_process +def: "The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:curators] +synonym: "tetracyclin transport" BROAD [] +synonym: "tetracycline transport" BROAD [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0015905 +name: bicyclomycin transmembrane transport +namespace: biological_process +def: "The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [PMID:20067529] +synonym: "bicyclomycin transport" BROAD [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015908 +name: fatty acid transport +namespace: biological_process +def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0015909 +name: long-chain fatty acid transport +namespace: biological_process +def: "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] +is_a: GO:0015908 ! fatty acid transport + +[Term] +id: GO:0015910 +name: long-chain fatty acid import into peroxisome +namespace: biological_process +def: "The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] +synonym: "peroxisomal long-chain fatty acid import" EXACT [] +synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015909 ! long-chain fatty acid transport +is_a: GO:0015919 ! peroxisomal membrane transport +is_a: GO:0032365 ! intracellular lipid transport +is_a: GO:1902001 ! fatty acid transmembrane transport + +[Term] +id: GO:0015911 +name: long-chain fatty acid import across plasma membrane +namespace: biological_process +def: "The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:ai] +synonym: "plasma membrane long-chain fatty acid transport" EXACT [] +is_a: GO:0044539 ! long-chain fatty acid import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1902001 ! fatty acid transmembrane transport + +[Term] +id: GO:0015912 +name: short-chain fatty acid transport +namespace: biological_process +def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport + +[Term] +id: GO:0015913 +name: short-chain fatty acid import +namespace: biological_process +def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6." [GOC:ai] +synonym: "short-chain fatty acid uptake" EXACT [] +is_a: GO:0015908 ! fatty acid transport + +[Term] +id: GO:0015914 +name: phospholipid transport +namespace: biological_process +def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015748 ! organophosphate ester transport + +[Term] +id: GO:0015915 +name: fatty-acyl group transport +namespace: biological_process +def: "The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai] +synonym: "fatty acyl transport" EXACT [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0015916 +name: fatty-acyl-CoA transport +namespace: biological_process +def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732] +synonym: "fatty acyl CoA transport" EXACT [] +synonym: "fatty acyl coenzyme A transport" EXACT [] +synonym: "fatty acyl-CoA transport" EXACT [] +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0042886 ! amide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:1901337 ! thioester transport + +[Term] +id: GO:0015917 +name: aminophospholipid transport +namespace: biological_process +def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] +is_a: GO:0015914 ! phospholipid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015918 +name: sterol transport +namespace: biological_process +def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0015919 +name: peroxisomal membrane transport +namespace: biological_process +def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai] +is_a: GO:0043574 ! peroxisomal transport + +[Term] +id: GO:0015920 +name: lipopolysaccharide transport +namespace: biological_process +def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai] +subset: goslim_pir +synonym: "LPS transport" EXACT [] +is_a: GO:0006869 ! lipid transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0015921 +name: lipopolysaccharide export +namespace: biological_process +def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai] +synonym: "LPS export" EXACT [] +is_a: GO:0015920 ! lipopolysaccharide transport + +[Term] +id: GO:0015922 +name: aspartate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.1, EC:1.4.3.16] +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0015923 +name: mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015924 +name: mannosyl-oligosaccharide mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] +xref: EC:3.2.1.- +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0015925 +name: galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015926 +name: glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015927 +name: trehalase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai, PMID:31925485] +xref: MetaCyc:TREHALA-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015928 +name: fucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015929 +name: hexosaminidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [ISBN:0721662544] +xref: MetaCyc:3.2.1.52-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0015930 +name: glutamate synthase activity +namespace: molecular_function +def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0015931 +name: nucleobase-containing compound transport +namespace: biological_process +def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +subset: goslim_yeast +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0015932 +name: nucleobase-containing compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0015933 +name: obsolete flavin-containing electron transporter +namespace: molecular_function +def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd] +comment: This term was made obsolete because it does not describe a molecular function. +synonym: "flavin-containing electron transporter" EXACT [] +is_obsolete: true +replaced_by: GO:0009055 + +[Term] +id: GO:0015934 +name: large ribosomal subunit +namespace: cellular_component +def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] +synonym: "ribosomal large subunit" EXACT [] +is_a: GO:0044391 ! ribosomal subunit + +[Term] +id: GO:0015935 +name: small ribosomal subunit +namespace: cellular_component +def: "The smaller of the two subunits of a ribosome." [GOC:mah] +subset: goslim_pir +synonym: "ribosomal small subunit" EXACT [] +is_a: GO:0044391 ! ribosomal subunit + +[Term] +id: GO:0015936 +name: coenzyme A metabolic process +namespace: biological_process +alt_id: GO:0006763 +def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +synonym: "CoA metabolism" EXACT [] +synonym: "coenzyme A metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process + +[Term] +id: GO:0015937 +name: coenzyme A biosynthetic process +namespace: biological_process +alt_id: GO:0006764 +def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +synonym: "CoA biosynthesis" EXACT [] +synonym: "coenzyme A anabolism" EXACT [] +synonym: "coenzyme A biosynthesis" EXACT [] +synonym: "coenzyme A formation" EXACT [] +synonym: "coenzyme A synthesis" EXACT [] +xref: MetaCyc:COA-PWY +xref: MetaCyc:PANTOSYN-PWY +xref: MetaCyc:PWY-4221 +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0015936 ! coenzyme A metabolic process +is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process +is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process + +[Term] +id: GO:0015938 +name: coenzyme A catabolic process +namespace: biological_process +alt_id: GO:0006765 +def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] +synonym: "CoA catabolism" EXACT [] +synonym: "coenzyme A breakdown" EXACT [] +synonym: "coenzyme A catabolism" EXACT [] +synonym: "coenzyme A degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0015936 ! coenzyme A metabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process + +[Term] +id: GO:0015939 +name: pantothenate metabolic process +namespace: biological_process +alt_id: GO:0006770 +def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] +synonym: "pantothenate metabolism" EXACT [] +synonym: "vitamin B5 metabolic process" EXACT [] +synonym: "vitamin B5 metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0015940 +name: pantothenate biosynthetic process +namespace: biological_process +alt_id: GO:0033317 +alt_id: GO:0033318 +def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] +synonym: "pantothenate anabolism" EXACT [] +synonym: "pantothenate anabolism from 2-oxypantoyl lactone" NARROW [] +synonym: "pantothenate anabolism from valine" NARROW [] +synonym: "pantothenate biosynthesis" EXACT [] +synonym: "pantothenate biosynthesis from 2-oxypantoyl lactone" NARROW [] +synonym: "pantothenate biosynthesis from valine" NARROW [] +synonym: "pantothenate biosynthetic process from 2-dehydropantolactone" NARROW [] +synonym: "pantothenate biosynthetic process from 2-oxypantoyl lactone" NARROW [] +synonym: "pantothenate biosynthetic process from valine" NARROW [] +synonym: "pantothenate formation" EXACT [] +synonym: "pantothenate formation from 2-oxypantoyl lactone" NARROW [] +synonym: "pantothenate formation from valine" NARROW [] +synonym: "pantothenate synthesis" EXACT [] +synonym: "pantothenate synthesis from 2-oxypantoyl lactone" NARROW [] +synonym: "pantothenate synthesis from valine" NARROW [] +synonym: "vitamin B5 biosynthesis" EXACT [] +synonym: "vitamin B5 biosynthetic process" EXACT [] +xref: MetaCyc:PANTO-PWY +xref: MetaCyc:PANTOSYN-PWY +xref: MetaCyc:PWY-3961 +xref: MetaCyc:PWY-4221 +is_a: GO:0015939 ! pantothenate metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0015941 +name: pantothenate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] +synonym: "pantothenate breakdown" EXACT [] +synonym: "pantothenate catabolism" EXACT [] +synonym: "pantothenate degradation" EXACT [] +synonym: "vitamin B5 catabolic process" EXACT [] +synonym: "vitamin B5 catabolism" EXACT [] +is_a: GO:0015939 ! pantothenate metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0015942 +name: formate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] +synonym: "formate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0015943 +name: formate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] +synonym: "formate anabolism" EXACT [] +synonym: "formate biosynthesis" EXACT [] +synonym: "formate formation" EXACT [] +synonym: "formate synthesis" EXACT [] +synonym: "formic acid biosynthesis" EXACT [] +synonym: "formic acid biosynthetic process" EXACT [] +is_a: GO:0015942 ! formate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0015944 +name: formate oxidation +namespace: biological_process +def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881] +synonym: "formic acid oxidation" EXACT [] +xref: MetaCyc:PWY-1881 +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0015945 +name: methanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732] +synonym: "methanol metabolism" EXACT [] +is_a: GO:0034308 ! primary alcohol metabolic process + +[Term] +id: GO:0015946 +name: methanol oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY] +xref: MetaCyc:CO2FORM-PWY +is_a: GO:0015945 ! methanol metabolic process + +[Term] +id: GO:0015947 +name: methane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732] +synonym: "methane metabolism" EXACT [] +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:0015948 +name: methanogenesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "methane biosynthesis" EXACT [] +synonym: "methane biosynthetic process" EXACT [] +xref: UM-BBD_pathwayID:meth +xref: Wikipedia:Methanogenesis +is_a: GO:0009061 ! anaerobic respiration +is_a: GO:0015947 ! methane metabolic process +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0043447 ! alkane biosynthetic process + +[Term] +id: GO:0015949 +name: nucleobase-containing small molecule interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +subset: goslim_pir +xref: MetaCyc:P1-PWY +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process + +[Term] +id: GO:0015950 +name: purine nucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0006163 ! purine nucleotide metabolic process +is_a: GO:0015949 ! nucleobase-containing small molecule interconversion + +[Term] +id: GO:0015951 +name: purine ribonucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0015950 ! purine nucleotide interconversion + +[Term] +id: GO:0015952 +name: purine deoxyribonucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0015950 ! purine nucleotide interconversion + +[Term] +id: GO:0015953 +name: pyrimidine nucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0006220 ! pyrimidine nucleotide metabolic process +is_a: GO:0015949 ! nucleobase-containing small molecule interconversion + +[Term] +id: GO:0015954 +name: pyrimidine ribonucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process +is_a: GO:0015953 ! pyrimidine nucleotide interconversion + +[Term] +id: GO:0015955 +name: pyrimidine deoxyribonucleotide interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process +is_a: GO:0015953 ! pyrimidine nucleotide interconversion + +[Term] +id: GO:0015956 +name: bis(5'-nucleosidyl) oligophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0015957 +name: bis(5'-nucleosidyl) oligophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process + +[Term] +id: GO:0015958 +name: bis(5'-nucleosidyl) oligophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] +synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT [] +synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process + +[Term] +id: GO:0015959 +name: diadenosine polyphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +synonym: "diadenosine polyphosphate metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0015960 +name: diadenosine polyphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +synonym: "diadenosine polyphosphate anabolism" EXACT [] +synonym: "diadenosine polyphosphate biosynthesis" EXACT [] +synonym: "diadenosine polyphosphate formation" EXACT [] +synonym: "diadenosine polyphosphate synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015961 +name: diadenosine polyphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] +synonym: "diadenosine polyphosphate breakdown" EXACT [] +synonym: "diadenosine polyphosphate catabolism" EXACT [] +synonym: "diadenosine polyphosphate degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015962 +name: diadenosine triphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +synonym: "diadenosine triphosphate metabolism" EXACT [] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015963 +name: diadenosine triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +synonym: "diadenosine triphosphate anabolism" EXACT [] +synonym: "diadenosine triphosphate biosynthesis" EXACT [] +synonym: "diadenosine triphosphate formation" EXACT [] +synonym: "diadenosine triphosphate synthesis" EXACT [] +is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process +is_a: GO:0015962 ! diadenosine triphosphate metabolic process + +[Term] +id: GO:0015964 +name: diadenosine triphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] +synonym: "diadenosine triphosphate breakdown" EXACT [] +synonym: "diadenosine triphosphate catabolism" EXACT [] +synonym: "diadenosine triphosphate degradation" EXACT [] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:0015962 ! diadenosine triphosphate metabolic process + +[Term] +id: GO:0015965 +name: diadenosine tetraphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +synonym: "diadenosine tetraphosphate metabolism" EXACT [] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:0015966 +name: diadenosine tetraphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +synonym: "diadenosine tetraphosphate anabolism" EXACT [] +synonym: "diadenosine tetraphosphate biosynthesis" EXACT [] +synonym: "diadenosine tetraphosphate formation" EXACT [] +synonym: "diadenosine tetraphosphate synthesis" EXACT [] +is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process +is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process + +[Term] +id: GO:0015967 +name: diadenosine tetraphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] +synonym: "diadenosine tetraphosphate breakdown" EXACT [] +synonym: "diadenosine tetraphosphate catabolism" EXACT [] +synonym: "diadenosine tetraphosphate degradation" EXACT [] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process + +[Term] +id: GO:0015968 +name: stringent response +namespace: biological_process +def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471] +xref: Wikipedia:Stringent_response +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0015969 +name: guanosine tetraphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT [] +synonym: "guanosine tetraphosphate metabolism" EXACT [] +xref: MetaCyc:PPGPPMET-PWY +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0015970 +name: guanosine tetraphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT [] +synonym: "guanosine tetraphosphate anabolism" EXACT [] +synonym: "guanosine tetraphosphate biosynthesis" EXACT [] +synonym: "guanosine tetraphosphate formation" EXACT [] +synonym: "guanosine tetraphosphate synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0015969 ! guanosine tetraphosphate metabolic process +is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process + +[Term] +id: GO:0015971 +name: guanosine tetraphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT [] +synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT [] +synonym: "guanosine tetraphosphate breakdown" EXACT [] +synonym: "guanosine tetraphosphate catabolism" EXACT [] +synonym: "guanosine tetraphosphate degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0015969 ! guanosine tetraphosphate metabolic process +is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process + +[Term] +id: GO:0015972 +name: guanosine pentaphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT [] +synonym: "guanosine pentaphosphate metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0015973 +name: guanosine pentaphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT [] +synonym: "guanosine pentaphosphate anabolism" EXACT [] +synonym: "guanosine pentaphosphate biosynthesis" EXACT [] +synonym: "guanosine pentaphosphate formation" EXACT [] +synonym: "guanosine pentaphosphate synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0015972 ! guanosine pentaphosphate metabolic process +is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process + +[Term] +id: GO:0015974 +name: guanosine pentaphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT [] +synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT [] +synonym: "guanosine pentaphosphate breakdown" EXACT [] +synonym: "guanosine pentaphosphate catabolism" EXACT [] +synonym: "guanosine pentaphosphate degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0015972 ! guanosine pentaphosphate metabolic process +is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process + +[Term] +id: GO:0015975 +name: energy derivation by oxidation of reduced inorganic compounds +namespace: biological_process +def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] +synonym: "chemolithotrophie" EXACT [] +synonym: "chemolithotrophy" EXACT [] +synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy] +xref: Wikipedia:Lithotrophy +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0015976 +name: carbon utilization +namespace: biological_process +alt_id: GO:0015978 +def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] +subset: goslim_chembl +subset: goslim_pir +synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] +synonym: "heterotrophy" EXACT [] +xref: Wikipedia:Heterotroph +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0015977 +name: carbon fixation +namespace: biological_process +def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah] +synonym: "autotrophic CO2 fixation" EXACT [] +synonym: "autotrophic CO2 fixation pathway" EXACT [] +synonym: "autotrophy" EXACT [] +synonym: "carbon dioxide fixation" NARROW [] +xref: Wikipedia:Carbon_fixation +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0015979 +name: photosynthesis +namespace: biological_process +def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +xref: Wikipedia:Photosynthesis +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0015980 +name: energy derivation by oxidation of organic compounds +namespace: biological_process +def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] +synonym: "chemoorganotrophy" EXACT [] +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0015981 +name: obsolete passive proton transport, down the electrochemical gradient +namespace: biological_process +def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363] +comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products. +synonym: "passive proton transport, down the electrochemical gradient" EXACT [] +is_obsolete: true +consider: GO:1902600 + +[Term] +id: GO:0015982 +name: obsolete antiport +namespace: biological_process +def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "antiport" EXACT [] +is_obsolete: true +replaced_by: GO:0015297 + +[Term] +id: GO:0015983 +name: obsolete symport +namespace: biological_process +def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "symport" EXACT [] +is_obsolete: true +replaced_by: GO:0015293 + +[Term] +id: GO:0015984 +name: obsolete uniport +namespace: biological_process +def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732] +comment: This term was made obsolete because it represents a molecular function rather than a biological process. +synonym: "uniport" EXACT [] +is_obsolete: true +replaced_by: GO:0015292 + +[Term] +id: GO:0015985 +name: energy coupled proton transport, down electrochemical gradient +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] +is_a: GO:1902600 ! proton transmembrane transport + +[Term] +id: GO:0015986 +name: ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] +synonym: "chemiosmosis" BROAD [GOC:rs] +is_a: GO:0006754 ! ATP biosynthetic process +is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient + +[Term] +id: GO:0015987 +name: GTP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363] +is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient + +[Term] +id: GO:0015988 +name: energy coupled proton transmembrane transport, against electrochemical gradient +namespace: biological_process +def: "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah] +is_a: GO:1902600 ! proton transmembrane transport + +[Term] +id: GO:0015989 +name: light-driven proton transport +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah] +is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient + +[Term] +id: GO:0015990 +name: electron transport coupled proton transport +namespace: biological_process +def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah] +is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient + +[Term] +id: GO:0015993 +name: obsolete molecular hydrogen transport +namespace: biological_process +def: "OBSOLETE. The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +comment: The reason for obsoletion is that there molecular hydrogen (H2) diffuses passively through membranes (see https://www.researchgate.net/post/How_molecular_hydrogen_is_transported_through_the_cytoplasmic_membrane_of_Escherichia_coli). +is_obsolete: true + +[Term] +id: GO:0015994 +name: chlorophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] +synonym: "chlorophyll metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process + +[Term] +id: GO:0015995 +name: chlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] +synonym: "chlorophyll anabolism" EXACT [] +synonym: "chlorophyll biosynthesis" EXACT [] +synonym: "chlorophyll formation" EXACT [] +synonym: "chlorophyll synthesis" EXACT [] +xref: MetaCyc:CHLOROPHYLL-SYN +is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process +is_a: GO:0015994 ! chlorophyll metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0015996 +name: chlorophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl] +synonym: "chlorophyll breakdown" EXACT [] +synonym: "chlorophyll catabolism" EXACT [] +synonym: "chlorophyll degradation" EXACT [] +is_a: GO:0006787 ! porphyrin-containing compound catabolic process +is_a: GO:0015994 ! chlorophyll metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0015997 +name: obsolete ubiquinone biosynthetic process monooxygenase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it incorporates biological process information. +synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT [] +synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT [] +synonym: "ubiquinone anabolism monooxygenase activity" EXACT [] +synonym: "ubiquinone biosynthetic process monooxygenase activity" EXACT [] +synonym: "ubiquinone formation monooxygenase activity" EXACT [] +synonym: "ubiquinone synthesis monooxygenase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016002 +name: sulfite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [GOC:curators] +synonym: "assimilatory sulfite reductase activity" EXACT [] +synonym: "assimilatory-type sulfite reductase activity" EXACT [] +synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [] +synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [] +synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] +synonym: "sulphite reductase activity" EXACT [] +xref: MetaCyc:SULFITE-REDUCTASE-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016004 +name: phospholipase activator activity +namespace: molecular_function +def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] +is_a: GO:0060229 ! lipase activator activity + +[Term] +id: GO:0016005 +name: phospholipase A2 activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] +is_a: GO:0016004 ! phospholipase activator activity + +[Term] +id: GO:0016006 +name: Nebenkern +namespace: cellular_component +def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma, PMID:25265054] +is_a: GO:0016007 ! mitochondrial derivative + +[Term] +id: GO:0016007 +name: mitochondrial derivative +namespace: cellular_component +def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0016008 +name: major mitochondrial derivative +namespace: cellular_component +def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236] +is_a: GO:0016007 ! mitochondrial derivative + +[Term] +id: GO:0016009 +name: minor mitochondrial derivative +namespace: cellular_component +def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504, PMID:24211517, PMID:30802236] +is_a: GO:0016007 ! mitochondrial derivative + +[Term] +id: GO:0016010 +name: dystrophin-associated glycoprotein complex +namespace: cellular_component +def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609] +subset: goslim_pir +synonym: "DGC" EXACT [] +synonym: "dystrophin glycoprotein complex" EXACT [] +is_a: GO:0090665 ! glycoprotein complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0016011 +name: dystroglycan complex +namespace: cellular_component +def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016012 +name: sarcoglycan complex +namespace: cellular_component +def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] +synonym: "sarcoglycan-sarcospan complex" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0016011 ! dystroglycan complex + +[Term] +id: GO:0016013 +name: syntrophin complex +namespace: cellular_component +def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] +synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016014 +name: dystrobrevin complex +namespace: cellular_component +def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex + +[Term] +id: GO:0016015 +name: morphogen activity +namespace: molecular_function +def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0016016 +name: obsolete short-wave-sensitive opsin +namespace: molecular_function +def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055] +comment: This term was made obsolete because it refers to a class of proteins. +synonym: "short-wave-sensitive opsin" EXACT [] +is_obsolete: true +consider: GO:0007603 +consider: GO:0009588 +consider: GO:0009881 +consider: GO:0016021 +consider: GO:0016918 +consider: GO:0046876 + +[Term] +id: GO:0016018 +name: cyclosporin A binding +namespace: molecular_function +def: "Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] +synonym: "cyclophilin" RELATED [] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0016019 +name: peptidoglycan immune receptor activity +namespace: molecular_function +def: "Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response." [PMID:14698226] +comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. +synonym: "peptidoglycan receptor activity" BROAD [] +synonym: "peptidoglycan recognition activity" NARROW [] +is_a: GO:0038187 ! pattern recognition receptor activity + +[Term] +id: GO:0016020 +name: membrane +namespace: cellular_component +alt_id: GO:0098589 +alt_id: GO:0098805 +def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "membrane region" NARROW [] +synonym: "region of membrane" NARROW [] +synonym: "whole membrane" NARROW [] +xref: Wikipedia:Biological_membrane +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0016021 +name: integral component of membrane +namespace: cellular_component +def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] +subset: goslim_chembl +synonym: "integral to membrane" NARROW [] +synonym: "transmembrane" RELATED [GOC:mah] +xref: Wikipedia:Transmembrane_protein +is_a: GO:0031224 ! intrinsic component of membrane + +[Term] +id: GO:0016024 +name: CDP-diacylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:24533860] +synonym: "CDP-diacylglycerol anabolism" EXACT [] +synonym: "CDP-diacylglycerol biosynthesis" EXACT [] +synonym: "CDP-diacylglycerol formation" EXACT [] +synonym: "CDP-diacylglycerol synthesis" EXACT [] +is_a: GO:0046341 ! CDP-diacylglycerol metabolic process +is_a: GO:0046474 ! glycerophospholipid biosynthetic process + +[Term] +id: GO:0016025 +name: obsolete proteasome endopeptidase regulator +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "proteasome endopeptidase regulator" EXACT [] +is_obsolete: true +consider: GO:0004175 + +[Term] +id: GO:0016026 +name: obsolete proteasome endopeptidase core +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "proteasome endopeptidase core" EXACT [] +is_obsolete: true +consider: GO:0004175 + +[Term] +id: GO:0016027 +name: inaD signaling complex +namespace: cellular_component +def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] +synonym: "inaD signalling complex" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0016028 ! rhabdomere +relationship: part_of GO:0019897 ! extrinsic component of plasma membrane + +[Term] +id: GO:0016028 +name: rhabdomere +namespace: cellular_component +def: "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] +subset: goslim_pir +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0016029 +name: subrhabdomeral cisterna +namespace: cellular_component +def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] +synonym: "SMC" RELATED [] +synonym: "submicrovillar cisterna" EXACT [PMID:11707492] +is_a: GO:0098827 ! endoplasmic reticulum subcompartment +is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0016031 +name: tRNA import into mitochondrion +namespace: biological_process +def: "The process in which a tRNA is transported from the cytosol into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736] +synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] +synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf] +synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] +synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] +synonym: "mitochondrial import of cytoplasmic tRNA" NARROW [] +synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf] +is_a: GO:0035927 ! RNA import into mitochondrion +is_a: GO:0051031 ! tRNA transport + +[Term] +id: GO:0016032 +name: viral process +namespace: biological_process +alt_id: GO:0022415 +def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] +comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. +subset: goslim_metagenomics +subset: goslim_pir +synonym: "viral infection" RELATED [] +synonym: "virulence" RELATED [] +synonym: "virus process" EXACT [GOC:bf, GOC:jl] +xref: Wikipedia:Viral_life_cycle +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0016034 +name: maleylacetoacetate isomerase activity +namespace: molecular_function +alt_id: GO:0018841 +def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] +synonym: "4-maleylacetoacetate cis-trans-isomerase activity" RELATED [EC:5.2.1.2] +synonym: "maleylacetoacetic isomerase activity" RELATED [EC:5.2.1.2] +synonym: "maleylacetone cis-trans-isomerase activity" RELATED [EC:5.2.1.2] +synonym: "maleylacetone isomerase activity" RELATED [EC:5.2.1.2] +xref: EC:5.2.1.2 +xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN +xref: Reactome:R-HSA-71173 "maleylacetoacetate => fumarylacetoacetate" +xref: RHEA:14817 +xref: UM-BBD_reactionID:r0106 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0016035 +name: zeta DNA polymerase complex +namespace: cellular_component +def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] +is_a: GO:0042575 ! DNA polymerase complex + +[Term] +id: GO:0016036 +name: cellular response to phosphate starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0016037 +name: light absorption +namespace: biological_process +def: "The reception of a photon by a cell." [GOC:go_curators] +synonym: "absorption of light" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0009583 ! detection of light stimulus + +[Term] +id: GO:0016038 +name: absorption of visible light +namespace: biological_process +def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0016037 ! light absorption + +[Term] +id: GO:0016039 +name: absorption of UV light +namespace: biological_process +def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0016037 ! light absorption + +[Term] +id: GO:0016040 +name: glutamate synthase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13753] +synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" RELATED [EC:1.4.1.14] +synonym: "GOGAT activity" BROAD [] +synonym: "L-glutamate synthase (NADH)" RELATED [EC:1.4.1.14] +synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] +synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] +synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" RELATED [EC:1.4.1.14] +synonym: "NADH-dependent glutamate synthase activity" RELATED [EC:1.4.1.14] +synonym: "NADH-glutamate synthase activity" RELATED [EC:1.4.1.14] +synonym: "NADH: GOGAT" RELATED [EC:1.4.1.14] +xref: EC:1.4.1.14 +xref: KEGG_REACTION:R00093 +xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN +xref: RHEA:13753 +is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor + +[Term] +id: GO:0016041 +name: glutamate synthase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "ferredoxin-dependent glutamate synthase activity" RELATED [EC:1.4.7.1] +synonym: "ferredoxin-glutamate synthase activity" RELATED [EC:1.4.7.1] +synonym: "glutamate synthase (ferredoxin-dependent)" RELATED [EC:1.4.7.1] +synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" RELATED [EC:1.4.7.1] +xref: EC:1.4.7.1 +xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN +xref: MetaCyc:PWY-4341 +xref: RHEA:12128 +is_a: GO:0015930 ! glutamate synthase activity +is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0016042 +name: lipid catabolic process +namespace: biological_process +alt_id: GO:0006724 +alt_id: GO:0044240 +def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] +synonym: "lipid breakdown" EXACT [] +synonym: "lipid catabolism" EXACT [] +synonym: "lipid degradation" EXACT [] +synonym: "lipolysis" EXACT [] +synonym: "multicellular organism lipid catabolic process" NARROW [] +synonym: "multicellular organismal lipid catabolic process" NARROW [] +xref: Wikipedia:Lipid_catabolism +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0016043 +name: cellular component organization +namespace: biological_process +alt_id: GO:0044235 +alt_id: GO:0071842 +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] +subset: goslim_agr +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +synonym: "cell organisation" EXACT [] +synonym: "cell organization and biogenesis" RELATED [GOC:mah] +synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] +synonym: "cellular component organisation in other organism" EXACT [GOC:mah] +synonym: "cellular component organization at cellular level" EXACT [] +synonym: "cellular component organization in other organism" EXACT [] +is_a: GO:0071840 ! cellular component organization or biogenesis + +[Term] +id: GO:0016045 +name: detection of bacterium +namespace: biological_process +alt_id: GO:0009598 +alt_id: GO:0009681 +def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of bacteria" EXACT [] +synonym: "perception of bacteria" RELATED [] +synonym: "perception of bacterium" RELATED [] +is_a: GO:0009617 ! response to bacterium +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0016046 +name: detection of fungus +namespace: biological_process +alt_id: GO:0009599 +alt_id: GO:0016047 +def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of fungi" EXACT [] +synonym: "detection of parasitic fungi" NARROW [] +synonym: "detection of parasitic fungus" NARROW [] +synonym: "perception of fungi" RELATED [] +synonym: "perception of fungus" RELATED [] +synonym: "perception of parasitic fungi" NARROW [] +synonym: "perception of parasitic fungus" RELATED [] +is_a: GO:0009620 ! response to fungus +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0016048 +name: detection of temperature stimulus +namespace: biological_process +def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] +synonym: "detection of temperature" EXACT [] +synonym: "detection of thermal stimulus" EXACT [] +synonym: "perception of temperature" RELATED [] +is_a: GO:0009266 ! response to temperature stimulus +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0016049 +name: cell growth +namespace: biological_process +alt_id: GO:0048591 +def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] +subset: gocheck_do_not_annotate +subset: goslim_drosophila +subset: goslim_pir +subset: goslim_plant +synonym: "cell expansion" RELATED [] +synonym: "cellular growth" EXACT [] +synonym: "growth of cell" EXACT [] +synonym: "metabolic process resulting in cell growth" RELATED [] +synonym: "metabolism resulting in cell growth" RELATED [] +synonym: "non-developmental cell growth" RELATED [GOC:mah] +synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] +is_a: GO:0009987 ! cellular process +is_a: GO:0040007 ! growth + +[Term] +id: GO:0016050 +name: vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] +subset: goslim_pir +subset: goslim_yeast +synonym: "vesicle organisation" EXACT [] +synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0016051 +name: carbohydrate biosynthetic process +namespace: biological_process +alt_id: GO:0006093 +def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] +synonym: "anabolic carbohydrate metabolic process" EXACT [] +synonym: "anabolic carbohydrate metabolism" EXACT [] +synonym: "carbohydrate anabolism" EXACT [] +synonym: "carbohydrate biosynthesis" EXACT [] +synonym: "carbohydrate formation" EXACT [] +synonym: "carbohydrate synthesis" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0016052 +name: carbohydrate catabolic process +namespace: biological_process +alt_id: GO:0006095 +alt_id: GO:0044276 +alt_id: GO:0044724 +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] +synonym: "carbohydrate breakdown" EXACT [] +synonym: "carbohydrate catabolism" EXACT [] +synonym: "carbohydrate degradation" EXACT [] +synonym: "catabolic carbohydrate metabolic process" EXACT [] +synonym: "catabolic carbohydrate metabolism" EXACT [] +synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] +synonym: "single-organism carbohydrate catabolic process" RELATED [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0016053 +name: organic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +synonym: "organic acid anabolism" EXACT [] +synonym: "organic acid biosynthesis" EXACT [] +synonym: "organic acid formation" EXACT [] +synonym: "organic acid synthesis" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0016054 +name: organic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] +synonym: "organic acid breakdown" EXACT [] +synonym: "organic acid catabolism" EXACT [] +synonym: "organic acid degradation" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0016055 +name: Wnt signaling pathway +namespace: biological_process +alt_id: GO:0007222 +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] +synonym: "frizzled signaling pathway" EXACT [] +synonym: "frizzled signalling pathway" EXACT [] +synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429] +synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429] +synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429] +synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429] +synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling] +synonym: "Wnt receptor signalling pathway" EXACT [] +synonym: "Wnt-activated signaling pathway" RELATED [] +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0198738 ! cell-cell signaling by wnt + +[Term] +id: GO:0016056 +name: rhodopsin mediated signaling pathway +namespace: biological_process +alt_id: GO:0009586 +def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] +synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf] +synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] +synonym: "rhodopsin signaling" EXACT [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0007602 ! phototransduction +is_a: GO:0071482 ! cellular response to light stimulus +relationship: part_of GO:0007603 ! phototransduction, visible light + +[Term] +id: GO:0016057 +name: regulation of membrane potential in photoreceptor cell +namespace: biological_process +def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] +synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0016058 +name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling +namespace: biological_process +def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] +synonym: "maintenance of rhodopsin mediated signaling" RELATED [] +synonym: "maintenance of rhodopsin mediated signalling" EXACT [] +is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell + +[Term] +id: GO:0016059 +name: deactivation of rhodopsin mediated signaling +namespace: biological_process +def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] +synonym: "deactivation of rhodopsin mediated signalling" EXACT [] +synonym: "rod response recovery" BROAD [GOC:bf] +is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway + +[Term] +id: GO:0016060 +name: metarhodopsin inactivation +namespace: biological_process +def: "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling + +[Term] +id: GO:0016061 +name: regulation of light-activated channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:0016062 +name: adaptation of rhodopsin mediated signaling +namespace: biological_process +def: "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] +synonym: "adaptation of rhodopsin mediated signalling" EXACT [] +is_a: GO:0023058 ! adaptation of signaling pathway +relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway +relationship: part_of GO:0036367 ! light adaption + +[Term] +id: GO:0016063 +name: rhodopsin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] +synonym: "rhodopsin anabolism" EXACT [] +synonym: "rhodopsin biosynthesis" EXACT [] +synonym: "rhodopsin formation" EXACT [] +synonym: "rhodopsin synthesis" EXACT [] +is_a: GO:0006726 ! eye pigment biosynthetic process +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046154 ! rhodopsin metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0016064 +name: immunoglobulin mediated immune response +namespace: biological_process +def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "antibody-mediated immune response" EXACT [] +is_a: GO:0019724 ! B cell mediated immunity + +[Term] +id: GO:0016065 +name: obsolete humoral defense mechanism (sensu Protostomia) +namespace: biological_process +def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid] +comment: This term was made obsolete because antibodies are not found in the taxon Protostomia. +synonym: "humoral defence mechanism (sensu Protostomia)" EXACT [] +synonym: "humoral defense mechanism (sensu Protostomia)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016068 +name: type I hypersensitivity +namespace: biological_process +def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] +comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. +synonym: "immediate hypersensitivity response" EXACT [] +xref: Wikipedia:Type_I_hypersensitivity +is_a: GO:0002524 ! hypersensitivity +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0016070 +name: RNA metabolic process +namespace: biological_process +def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_metagenomics +subset: goslim_pir +synonym: "RNA metabolism" EXACT [] +is_a: GO:0090304 ! nucleic acid metabolic process + +[Term] +id: GO:0016071 +name: mRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "mRNA metabolism" EXACT [] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0016072 +name: rRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] +subset: goslim_drosophila +synonym: "rRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016073 +name: snRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "snRNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016074 +name: sno(s)RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] +subset: goslim_drosophila +subset: goslim_pombe +synonym: "box C/D sRNA metabolic process" NARROW [] +synonym: "snoRNA metabolism" NARROW [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0016075 +name: rRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] +synonym: "rRNA breakdown" EXACT [] +synonym: "rRNA catabolism" EXACT [] +synonym: "rRNA degradation" EXACT [] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016076 +name: snRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] +synonym: "snRNA breakdown" EXACT [] +synonym: "snRNA catabolism" EXACT [] +synonym: "snRNA degradation" EXACT [] +is_a: GO:0016073 ! snRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016077 +name: sno(s)RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [GOC:krc, ISBN:0198506732] +synonym: "sno(s)RNA breakdown" EXACT [] +synonym: "sno(s)RNA catabolism" EXACT [] +synonym: "sno(s)RNA degradation" EXACT [] +synonym: "snoRNA catabolic process" NARROW [] +synonym: "sRNA catabolic process" NARROW [] +is_a: GO:0016074 ! sno(s)RNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016078 +name: tRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai] +synonym: "tRNA breakdown" EXACT [] +synonym: "tRNA catabolism" EXACT [] +synonym: "tRNA degradation" EXACT [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0016079 +name: synaptic vesicle exocytosis +namespace: biological_process +def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] +subset: goslim_synapse +is_a: GO:0045055 ! regulated exocytosis +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099003 ! vesicle-mediated transport in synapse +is_a: GO:0099643 ! signal release from synapse +relationship: part_of GO:0007269 ! neurotransmitter secretion +relationship: part_of GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0016080 +name: synaptic vesicle targeting +namespace: biological_process +def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] +is_a: GO:0006903 ! vesicle targeting +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016081 +name: synaptic vesicle docking +namespace: biological_process +def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process." [PMID:15217342] +comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015). +subset: goslim_synapse +synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] +synonym: "synaptic vesicle docking involved in exocytosis" EXACT [] +is_a: GO:0006904 ! vesicle docking involved in exocytosis +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016082 +name: synaptic vesicle priming +namespace: biological_process +def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190] +comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015) +subset: goslim_synapse +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0016083 +name: obsolete synaptic vesicle fusion +namespace: biological_process +def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators] +comment: This term was made obsolete because it was wrongly defined. +synonym: "synaptic vesicle fusion" EXACT [] +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016084 +name: myostimulatory hormone activity +namespace: molecular_function +def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016085 +name: myoinhibitory hormone activity +namespace: molecular_function +def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016086 +name: obsolete allatostatin +namespace: molecular_function +def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383] +comment: This term was made obsolete because it refers to a gene product. +synonym: "allatostatin" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0045968 + +[Term] +id: GO:0016087 +name: ecdysiostatic hormone activity +namespace: molecular_function +def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah] +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0016088 +name: obsolete insulin +namespace: molecular_function +def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "insulin" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0045722 +consider: GO:0045727 +consider: GO:0045935 +consider: GO:0046326 +consider: GO:0046889 + +[Term] +id: GO:0016090 +name: prenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684] +synonym: "prenol metabolism" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0016091 +name: prenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] +synonym: "prenol anabolism" EXACT [] +synonym: "prenol biosynthesis" EXACT [] +synonym: "prenol formation" EXACT [] +synonym: "prenol synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0016090 ! prenol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:0016092 +name: prenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] +synonym: "prenol breakdown" EXACT [] +synonym: "prenol catabolism" EXACT [] +synonym: "prenol degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0016090 ! prenol metabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0016093 +name: polyprenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [PMID:11108713] +synonym: "polyprenol metabolism" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0016094 +name: polyprenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, PMID:11108713] +synonym: "polyprenol anabolism" EXACT [] +synonym: "polyprenol biosynthesis" EXACT [] +synonym: "polyprenol formation" EXACT [] +synonym: "polyprenol synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0016093 ! polyprenol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0016095 +name: polyprenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, Wikipedia:Polyprenol] +synonym: "polyprenol breakdown" EXACT [] +synonym: "polyprenol catabolism" EXACT [] +synonym: "polyprenol degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0016093 ! polyprenol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0016098 +name: monoterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [ISBN:0198547684] +synonym: "monoterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016099 +name: monoterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators] +synonym: "monoterpenoid anabolism" EXACT [] +synonym: "monoterpenoid biosynthesis" EXACT [] +synonym: "monoterpenoid formation" EXACT [] +synonym: "monoterpenoid synthesis" EXACT [] +xref: MetaCyc:PWY-3041 +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016100 +name: monoterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [GOC:go_curators] +synonym: "monoterpenoid breakdown" EXACT [] +synonym: "monoterpenoid catabolism" EXACT [] +synonym: "monoterpenoid degradation" EXACT [] +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016101 +name: diterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] +synonym: "diterpene metabolic process" NARROW [] +synonym: "diterpene metabolism" NARROW [] +synonym: "diterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016102 +name: diterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] +synonym: "diterpene biosynthesis" NARROW [] +synonym: "diterpene biosynthetic process" NARROW [] +synonym: "diterpenoid anabolism" EXACT [] +synonym: "diterpenoid biosynthesis" EXACT [] +synonym: "diterpenoid formation" EXACT [] +synonym: "diterpenoid synthesis" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016103 +name: diterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] +synonym: "diterpene catabolic process" NARROW [] +synonym: "diterpene catabolism" NARROW [] +synonym: "diterpenoid breakdown" EXACT [] +synonym: "diterpenoid catabolism" EXACT [] +synonym: "diterpenoid degradation" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016104 +name: triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] +synonym: "triterpene biosynthesis" NARROW [] +synonym: "triterpene biosynthetic process" NARROW [] +synonym: "triterpenoid anabolism" EXACT [] +synonym: "triterpenoid biosynthesis" EXACT [] +synonym: "triterpenoid formation" EXACT [] +synonym: "triterpenoid synthesis" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016105 +name: triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] +synonym: "triterpene catabolic process" NARROW [] +synonym: "triterpene catabolism" NARROW [] +synonym: "triterpenoid breakdown" EXACT [] +synonym: "triterpenoid catabolism" EXACT [] +synonym: "triterpenoid degradation" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016106 +name: sesquiterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] +synonym: "sesquiterpenoid anabolism" EXACT [] +synonym: "sesquiterpenoid biosynthesis" EXACT [] +synonym: "sesquiterpenoid formation" EXACT [] +synonym: "sesquiterpenoid synthesis" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016107 +name: sesquiterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] +synonym: "sesquiterpenoid breakdown" EXACT [] +synonym: "sesquiterpenoid catabolism" EXACT [] +synonym: "sesquiterpenoid degradation" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016108 +name: tetraterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684] +synonym: "tetraterpene metabolic process" NARROW [] +synonym: "tetraterpene metabolism" NARROW [] +synonym: "tetraterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016109 +name: tetraterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] +synonym: "tetraterpene biosynthesis" NARROW [] +synonym: "tetraterpene biosynthetic process" NARROW [] +synonym: "tetraterpenoid anabolism" EXACT [] +synonym: "tetraterpenoid biosynthesis" EXACT [] +synonym: "tetraterpenoid formation" EXACT [] +synonym: "tetraterpenoid synthesis" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016110 +name: tetraterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] +synonym: "tetraterpene catabolic process" NARROW [] +synonym: "tetraterpene catabolism" NARROW [] +synonym: "tetraterpenoid breakdown" EXACT [] +synonym: "tetraterpenoid catabolism" EXACT [] +synonym: "tetraterpenoid degradation" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016111 +name: polyterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684] +synonym: "polyterpene metabolic process" NARROW [] +synonym: "polyterpene metabolism" NARROW [] +synonym: "polyterpenoid metabolism" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0016112 +name: polyterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] +synonym: "polyterpene biosynthesis" NARROW [] +synonym: "polyterpene biosynthetic process" NARROW [] +synonym: "polyterpenoid anabolism" EXACT [] +synonym: "polyterpenoid biosynthesis" EXACT [] +synonym: "polyterpenoid formation" EXACT [] +synonym: "polyterpenoid synthesis" EXACT [] +is_a: GO:0016111 ! polyterpenoid metabolic process +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0016113 +name: polyterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] +synonym: "polyterpene catabolic process" NARROW [] +synonym: "polyterpene catabolism" NARROW [] +synonym: "polyterpenoid breakdown" EXACT [] +synonym: "polyterpenoid catabolism" EXACT [] +synonym: "polyterpenoid degradation" EXACT [] +is_a: GO:0016111 ! polyterpenoid metabolic process +is_a: GO:0016115 ! terpenoid catabolic process + +[Term] +id: GO:0016114 +name: terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] +synonym: "terpenoid anabolism" EXACT [] +synonym: "terpenoid biosynthesis" EXACT [] +synonym: "terpenoid formation" EXACT [] +synonym: "terpenoid synthesis" EXACT [] +xref: Wikipedia:Terpenoid +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:0016115 +name: terpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] +synonym: "terpenoid breakdown" EXACT [] +synonym: "terpenoid catabolism" EXACT [] +synonym: "terpenoid degradation" EXACT [] +is_a: GO:0006721 ! terpenoid metabolic process +is_a: GO:0008300 ! isoprenoid catabolic process + +[Term] +id: GO:0016116 +name: carotenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] +synonym: "carotenoid metabolism" EXACT [] +is_a: GO:0016108 ! tetraterpenoid metabolic process + +[Term] +id: GO:0016117 +name: carotenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] +synonym: "carotenoid anabolism" EXACT [] +synonym: "carotenoid biosynthesis" EXACT [] +synonym: "carotenoid formation" EXACT [] +synonym: "carotenoid synthesis" EXACT [] +xref: MetaCyc:CAROTENOID-PWY +is_a: GO:0016109 ! tetraterpenoid biosynthetic process +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0016118 +name: carotenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] +synonym: "carotenoid breakdown" EXACT [] +synonym: "carotenoid catabolism" EXACT [] +synonym: "carotenoid degradation" EXACT [] +is_a: GO:0016110 ! tetraterpenoid catabolic process +is_a: GO:0016116 ! carotenoid metabolic process + +[Term] +id: GO:0016119 +name: carotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] +synonym: "carotene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0016120 +name: carotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators] +synonym: "carotene anabolism" EXACT [] +synonym: "carotene biosynthesis" EXACT [] +synonym: "carotene formation" EXACT [] +synonym: "carotene synthesis" EXACT [] +is_a: GO:0016119 ! carotene metabolic process +is_a: GO:0046246 ! terpene biosynthetic process + +[Term] +id: GO:0016121 +name: carotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators] +synonym: "carotene breakdown" EXACT [] +synonym: "carotene catabolism" EXACT [] +synonym: "carotene degradation" EXACT [] +is_a: GO:0016119 ! carotene metabolic process +is_a: GO:0046247 ! terpene catabolic process + +[Term] +id: GO:0016122 +name: xanthophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] +synonym: "xanthophyll metabolism" EXACT [] +is_a: GO:0016116 ! carotenoid metabolic process + +[Term] +id: GO:0016123 +name: xanthophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] +synonym: "xanthophyll anabolism" EXACT [] +synonym: "xanthophyll biosynthesis" EXACT [] +synonym: "xanthophyll formation" EXACT [] +synonym: "xanthophyll synthesis" EXACT [] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0016124 +name: xanthophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] +synonym: "xanthophyll breakdown" EXACT [] +synonym: "xanthophyll catabolism" EXACT [] +synonym: "xanthophyll degradation" EXACT [] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0016125 +name: sterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] +synonym: "sterol metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0016126 +name: sterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] +synonym: "sterol anabolism" EXACT [] +synonym: "sterol biosynthesis" EXACT [] +synonym: "sterol formation" EXACT [] +synonym: "sterol synthesis" EXACT [] +xref: MetaCyc:PWY-2541 +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0016127 +name: sterol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] +synonym: "sterol breakdown" EXACT [] +synonym: "sterol catabolism" EXACT [] +synonym: "sterol degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0016128 +name: phytosteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684] +synonym: "phytosteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0016129 +name: phytosteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309] +synonym: "phytosteroid anabolism" EXACT [] +synonym: "phytosteroid biosynthesis" EXACT [] +synonym: "phytosteroid formation" EXACT [] +synonym: "phytosteroid synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0016128 ! phytosteroid metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0016130 +name: phytosteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah] +synonym: "phytosteroid breakdown" EXACT [] +synonym: "phytosteroid catabolism" EXACT [] +synonym: "phytosteroid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016128 ! phytosteroid metabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0016131 +name: brassinosteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +synonym: "brassinosteroid metabolism" EXACT [] +is_a: GO:0016128 ! phytosteroid metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0016132 +name: brassinosteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +synonym: "brassinosteroid anabolism" EXACT [] +synonym: "brassinosteroid biosynthesis" EXACT [] +synonym: "brassinosteroid formation" EXACT [] +synonym: "brassinosteroid synthesis" EXACT [] +xref: MetaCyc:PWY-2582 +xref: MetaCyc:PWY-699 +is_a: GO:0016129 ! phytosteroid biosynthetic process +is_a: GO:0016131 ! brassinosteroid metabolic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0016133 +name: brassinosteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] +synonym: "brassinosteroid breakdown" EXACT [] +synonym: "brassinosteroid catabolism" EXACT [] +synonym: "brassinosteroid degradation" EXACT [] +is_a: GO:0016130 ! phytosteroid catabolic process +is_a: GO:0016131 ! brassinosteroid metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0016134 +name: saponin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684] +synonym: "saponin metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0016135 +name: saponin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] +synonym: "saponin anabolism" EXACT [] +synonym: "saponin biosynthesis" EXACT [] +synonym: "saponin formation" EXACT [] +synonym: "saponin synthesis" EXACT [] +is_a: GO:0016134 ! saponin metabolic process +is_a: GO:0016138 ! glycoside biosynthetic process + +[Term] +id: GO:0016136 +name: saponin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] +synonym: "saponin breakdown" EXACT [] +synonym: "saponin catabolism" EXACT [] +synonym: "saponin degradation" EXACT [] +is_a: GO:0016134 ! saponin metabolic process +is_a: GO:0016139 ! glycoside catabolic process + +[Term] +id: GO:0016137 +name: glycoside metabolic process +namespace: biological_process +alt_id: GO:0016140 +def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684] +synonym: "glycoside metabolism" EXACT [] +synonym: "O-glycoside metabolic process" EXACT [] +synonym: "O-glycoside metabolism" EXACT [] +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:0016138 +name: glycoside biosynthetic process +namespace: biological_process +alt_id: GO:0016141 +def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] +synonym: "glycoside anabolism" EXACT [] +synonym: "glycoside biosynthesis" EXACT [] +synonym: "glycoside formation" EXACT [] +synonym: "glycoside synthesis" EXACT [] +synonym: "O-glycoside anabolism" EXACT [] +synonym: "O-glycoside biosynthesis" EXACT [] +synonym: "O-glycoside biosynthetic process" EXACT [] +synonym: "O-glycoside formation" EXACT [] +synonym: "O-glycoside synthesis" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:1901659 ! glycosyl compound biosynthetic process + +[Term] +id: GO:0016139 +name: glycoside catabolic process +namespace: biological_process +alt_id: GO:0016142 +def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] +synonym: "glycoside breakdown" EXACT [] +synonym: "glycoside catabolism" EXACT [] +synonym: "glycoside degradation" EXACT [] +synonym: "O-glycoside breakdown" EXACT [] +synonym: "O-glycoside catabolic process" EXACT [] +synonym: "O-glycoside catabolism" EXACT [] +synonym: "O-glycoside degradation" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:1901658 ! glycosyl compound catabolic process + +[Term] +id: GO:0016143 +name: S-glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] +synonym: "S-glycoside metabolism" EXACT [] +synonym: "thioglycoside metabolic process" EXACT [] +synonym: "thioglycoside metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:0016144 +name: S-glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] +synonym: "S-glycoside anabolism" EXACT [] +synonym: "S-glycoside biosynthesis" EXACT [] +synonym: "S-glycoside formation" EXACT [] +synonym: "S-glycoside synthesis" EXACT [] +synonym: "thioglycoside biosynthesis" EXACT [] +synonym: "thioglycoside biosynthetic process" EXACT [] +is_a: GO:0016143 ! S-glycoside metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901659 ! glycosyl compound biosynthetic process + +[Term] +id: GO:0016145 +name: S-glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] +synonym: "S-glycoside breakdown" EXACT [] +synonym: "S-glycoside catabolism" EXACT [] +synonym: "S-glycoside degradation" EXACT [] +synonym: "thioglycoside catabolic process" EXACT [] +synonym: "thioglycoside catabolism" EXACT [] +is_a: GO:0016143 ! S-glycoside metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901658 ! glycosyl compound catabolic process + +[Term] +id: GO:0016146 +name: obsolete protein-synthesizing GTPase activity, initiation +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +synonym: "protein-synthesizing GTPase activity, initiation" EXACT [] +is_obsolete: true +consider: GO:0003743 +consider: GO:0003924 +consider: GO:0006412 +consider: GO:0006413 + +[Term] +id: GO:0016147 +name: obsolete protein-synthesizing GTPase activity, elongation +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +synonym: "protein-synthesizing GTPase activity, elongation" EXACT [] +is_obsolete: true +consider: GO:0003746 +consider: GO:0003924 +consider: GO:0006412 +consider: GO:0006414 + +[Term] +id: GO:0016148 +name: obsolete protein-synthesizing GTPase activity, termination +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] +comment: This term was made obsolete because it contains both process and function information. +synonym: "protein-synthesizing GTPase activity, termination" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0006412 +consider: GO:0006415 +consider: GO:0008079 + +[Term] +id: GO:0016149 +name: translation release factor activity, codon specific +namespace: molecular_function +def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] +is_a: GO:0003747 ! translation release factor activity + +[Term] +id: GO:0016150 +name: translation release factor activity, codon nonspecific +namespace: molecular_function +def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] +is_a: GO:0003747 ! translation release factor activity + +[Term] +id: GO:0016151 +name: nickel cation binding +namespace: molecular_function +def: "Binding to a nickel (Ni) cation." [GOC:ai] +synonym: "Ni binding" EXACT [] +synonym: "nickel binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0016152 +name: mercury (II) reductase activity +namespace: molecular_function +alt_id: GO:0018692 +def: "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [RHEA:23856] +synonym: "Hg:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.1] +synonym: "mer A" RELATED [EC:1.16.1.1] +synonym: "mercurate(II) reductase activity" RELATED [EC:1.16.1.1] +synonym: "mercuric ion reductase activity" RELATED [EC:1.16.1.1] +synonym: "mercuric reductase activity" RELATED [EC:1.16.1.1] +synonym: "mercury reductase activity" RELATED [EC:1.16.1.1] +synonym: "mercury(II) reductase activity" RELATED [EC:1.16.1.1] +synonym: "reduced NADP:mercuric ion oxidoreductase activity" RELATED [EC:1.16.1.1] +xref: EC:1.16.1.1 +xref: KEGG_REACTION:R02807 +xref: MetaCyc:MERCURY-II-REDUCTASE-RXN +xref: RHEA:23856 +xref: UM-BBD_reactionID:r0406 +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0016153 +name: urocanate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13101] +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" RELATED [EC:4.2.1.49] +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" RELATED [EC:4.2.1.49] +synonym: "imidazolonepropionate hydrolase activity" RELATED [EC:4.2.1.49] +synonym: "urocanase activity" RELATED [EC:4.2.1.49] +xref: EC:4.2.1.49 +xref: KEGG_REACTION:R02914 +xref: MetaCyc:UROCANATE-HYDRATASE-RXN +xref: Reactome:R-HSA-70903 "urocanate + H2O => 4-imidazolone-5-propionate" +xref: RHEA:13101 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0016154 +name: pyrimidine-nucleoside phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] +synonym: "Py-NPase activity" RELATED [EC:2.4.2.2] +synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.2] +xref: EC:2.4.2.2 +xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0016155 +name: formyltetrahydrofolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10180] +synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" RELATED [EC:1.5.1.6] +synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" RELATED [EC:1.5.1.6] +synonym: "10-formyl-H4folate dehydrogenase activity" RELATED [EC:1.5.1.6] +synonym: "10-formyltetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.6] +synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.6] +synonym: "N10-formyltetrahydrofolate dehydrogenase activity" RELATED [EC:1.5.1.6] +xref: EC:1.5.1.6 +xref: KEGG_REACTION:R00941 +xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN +xref: RHEA:10180 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016156 +name: fumarate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [EC:1.3.1.6, RHEA:18281] +synonym: "NADH-dependent fumarate reductase activity" RELATED [EC:1.3.1.6] +synonym: "NADH-fumarate reductase activity" RELATED [EC:1.3.1.6] +synonym: "succinate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.6] +xref: EC:1.3.1.6 +xref: KEGG_REACTION:R00402 +xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN +xref: RHEA:18281 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016157 +name: sucrose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] +synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.13] +synonym: "sucrose synthetase activity" RELATED [EC:2.4.1.13] +synonym: "sucrose-UDP glucosyltransferase activity" RELATED [EC:2.4.1.13] +synonym: "sucrose-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.13] +synonym: "UDP-glucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13] +synonym: "UDPglucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13] +synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" RELATED [EC:2.4.1.13] +xref: EC:2.4.1.13 +xref: MetaCyc:SUCROSE-SYNTHASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016158 +name: 3-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] +synonym: "1-phytase activity" RELATED [EC:3.1.3.8] +synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.8] +synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] +synonym: "phytase activity" BROAD [] +synonym: "phytate 1-phosphatase activity" RELATED [EC:3.1.3.8] +synonym: "phytate 3-phosphatase activity" EXACT [] +xref: EC:3.1.3.8 +xref: MetaCyc:RXN0-1001 +xref: RHEA:16989 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0016159 +name: muconolactone delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] +synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" RELATED [EC:5.3.3.4] +synonym: "muconolactone D-isomerase activity" EXACT [] +synonym: "muconolactone isomerase activity" RELATED [EC:5.3.3.4] +xref: EC:5.3.3.4 +xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN +xref: RHEA:12348 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0016160 +name: amylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016161 +name: beta-amylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [PMID:18390594] +synonym: "4-alpha-D-glucan maltohydrolase activity" RELATED [EC:3.2.1.2] +synonym: "beta amylase activity" RELATED [] +synonym: "glycogenase activity" BROAD [EC:3.2.1.2] +synonym: "saccharogen amylase activity" RELATED [EC:3.2.1.2] +xref: EC:3.2.1.2 +xref: MetaCyc:RXN-12279 +xref: MetaCyc:RXN-1827 +is_a: GO:0016160 ! amylase activity + +[Term] +id: GO:0016162 +name: cellulose 1,4-beta-cellobiosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] +synonym: "1,4-beta-cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "1,4-beta-D-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "1,4-beta-glucan cellobiosidase activity" RELATED [EC:3.2.1.91] +synonym: "avicelase activity" BROAD [EC:3.2.1.91] +synonym: "beta-1,4-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "beta-1,4-glucan cellobiosylhydrolase activity" RELATED [EC:3.2.1.91] +synonym: "C1 cellulase activity" RELATED [EC:3.2.1.91] +synonym: "CBH 1" RELATED [EC:3.2.1.91] +synonym: "cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] +synonym: "cellobiosidase activity" RELATED [EC:3.2.1.91] +synonym: "exo-1,4-beta-D-glucanase activity" RELATED [EC:3.2.1.91] +synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "exo-cellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "exocellobiohydrolase activity" RELATED [EC:3.2.1.91] +synonym: "exoglucanase activity" RELATED [EC:3.2.1.91] +xref: EC:3.2.1.91 +xref: MetaCyc:3.2.1.91-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016163 +name: nitrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [PMID:15382920, RHEA:21448] +synonym: "iron-iron nitrogenase activity" NARROW [] +synonym: "molybdenum-iron nitrogenase activity" NARROW [] +synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" RELATED [EC:1.18.6.1] +synonym: "vanadium-iron nitrogenase activity" NARROW [] +xref: EC:1.18.6.1 +xref: MetaCyc:NITROGENASE-RXN +xref: RHEA:21448 +xref: UM-BBD_enzymeID:e0395 +is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor + +[Term] +id: GO:0016164 +name: obsolete Mo-molybdopterin oxidoreductase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined. +synonym: "Mo-molybdopterin oxidoreductase activity" EXACT [] +synonym: "molybdopterin oxidoreductase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016491 + +[Term] +id: GO:0016165 +name: linoleate 13S-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb] +synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] +synonym: "fat oxidase activity" RELATED [EC:1.13.11.12] +synonym: "linoleate:oxygen 13-oxidoreductase activity" RELATED [EC:1.13.11.12] +synonym: "lionoleate:O2 oxidoreductase activity" RELATED [EC:1.13.11.12] +synonym: "lipoperoxidase activity" RELATED [EC:1.13.11.12] +synonym: "lipoxidase activity" RELATED [EC:1.13.11.12] +synonym: "lipoxydase activity" RELATED [EC:1.13.11.12] +synonym: "lipoxygenase activity" BROAD [] +xref: EC:1.13.11.12 +xref: MetaCyc:LIPOXYGENASE-RXN +xref: RHEA:22780 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0016166 +name: phytoene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [PMID:29176862] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016167 +name: glial cell-derived neurotrophic factor receptor activity +namespace: molecular_function +def: "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] +synonym: "GDNF receptor activity" EXACT [GOC:mah] +synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0016168 +name: chlorophyll binding +namespace: molecular_function +def: "Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] +is_a: GO:0046906 ! tetrapyrrole binding + +[Term] +id: GO:0016169 +name: bacteriochlorophyll c binding +namespace: molecular_function +def: "Binding to bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] +is_a: GO:0042314 ! bacteriochlorophyll binding + +[Term] +id: GO:0016170 +name: interleukin-15 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-15 receptor." [GOC:ai] +synonym: "IL-15" NARROW [] +synonym: "interleukin-15 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0016171 +name: obsolete cell surface antigen +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "cell surface antigen" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016172 +name: obsolete antifreeze activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] +comment: This term was made obsolete because it refers to a biological process. +synonym: "antifreeze activity" EXACT [] +is_obsolete: true +consider: GO:0042309 +consider: GO:0050825 +consider: GO:0050826 + +[Term] +id: GO:0016173 +name: obsolete ice nucleation inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai] +comment: This term was made obsolete because it refers to a biological process. +synonym: "ice nucleation inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0042309 +consider: GO:0050825 +consider: GO:0050826 + +[Term] +id: GO:0016174 +name: NAD(P)H oxidase H2O2-forming activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874, RHEA:11260] +synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] +synonym: "NAD(P)H oxidase activity" BROAD [] +synonym: "NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.6.3.1] +synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] +synonym: "p138tox" RELATED [EC:1.6.3.1] +synonym: "ThOX activity" NARROW [EC:1.6.3.1] +synonym: "THOX2 activity" NARROW [EC:1.6.3.1] +synonym: "thyroid NADPH oxidase activity" NARROW [] +synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] +synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] +xref: EC:1.6.3.1 +xref: Reactome:R-HSA-5693681 "DUOX1,2 reduce O2 to H2O2" +xref: Reactome:R-HSA-9698758 "FLT3 ITD- and NOX4-dependent H2O2 production" +is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor + +[Term] +id: GO:0016175 +name: superoxide-generating NAD(P)H oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] +synonym: "cytochrome B-245" RELATED [] +xref: EC:1.6.3.- +xref: Reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen" +xref: Reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2" +xref: Reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide" +xref: Reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen" +xref: Reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP" +xref: Reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen" +xref: Reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen" +xref: Reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen" +xref: Reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-" +xref: Reactome:R-HSA-9673797 "NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen" +is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor + +[Term] +id: GO:0016176 +name: superoxide-generating NADPH oxidase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] +synonym: "neutrophil cytosol factor 2" NARROW [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016180 +name: snRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] +is_a: GO:0016073 ! snRNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0016182 +name: synaptic vesicle budding from endosome +namespace: biological_process +def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709, PMID:24596248] +subset: goslim_synapse +synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] +synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0070142 ! synaptic vesicle budding +is_a: GO:0099003 ! vesicle-mediated transport in synapse +relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome + +[Term] +id: GO:0016183 +name: synaptic vesicle coating +namespace: biological_process +def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150] +subset: goslim_synapse +is_a: GO:0006901 ! vesicle coating +relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane + +[Term] +id: GO:0016184 +name: obsolete synaptic vesicle retrieval +namespace: biological_process +def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators] +comment: This term was made obsolete because it was wrongly defined. +synonym: "synaptic vesicle retrieval" EXACT [] +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016185 +name: synaptic vesicle budding from presynaptic endocytic zone membrane +namespace: biological_process +def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150] +subset: goslim_synapse +synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT [] +synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah] +is_a: GO:0070142 ! synaptic vesicle budding +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016186 +name: obsolete synaptic vesicle fission +namespace: biological_process +def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators] +comment: This term was made obsolete because it was wrongly defined. +synonym: "synaptic vesicle fission" EXACT [] +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016187 +name: obsolete synaptic vesicle internalization +namespace: biological_process +def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators] +comment: This term was made obsolete because it was wrongly defined. +synonym: "synaptic vesicle internalization" EXACT [] +is_obsolete: true +consider: GO:0016192 + +[Term] +id: GO:0016188 +name: synaptic vesicle maturation +namespace: biological_process +def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0021700 ! developmental maturation + +[Term] +id: GO:0016189 +name: synaptic vesicle to endosome fusion +namespace: biological_process +def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709] +comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. +subset: goslim_synapse +is_a: GO:0007032 ! endosome organization +is_a: GO:0048284 ! organelle fusion +relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing + +[Term] +id: GO:0016191 +name: synaptic vesicle uncoating +namespace: biological_process +def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248] +subset: goslim_synapse +synonym: "synaptic vesicle coat depolymerization" EXACT [] +synonym: "synaptic vesicle coat protein depolymerization" EXACT [] +is_a: GO:0072318 ! clathrin coat disassembly +relationship: part_of GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0016192 +name: vesicle-mediated transport +namespace: biological_process +alt_id: GO:0006899 +def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +synonym: "nonselective vesicle transport" NARROW [] +synonym: "protein sorting along secretory pathway" RELATED [] +synonym: "vesicle trafficking" RELATED [] +synonym: "vesicle transport" EXACT [] +synonym: "vesicular transport" EXACT [GOC:mah] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0016197 +name: endosomal transport +namespace: biological_process +alt_id: GO:0032439 +def: "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732] +subset: goslim_yeast +synonym: "endosome localisation" EXACT [GOC:mah] +synonym: "endosome localization" RELATED [] +synonym: "endosome transport" RELATED [GOC:bf] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0016198 +name: axon choice point recognition +namespace: biological_process +def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] +is_a: GO:0008038 ! neuron recognition +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:0016199 +name: axon midline choice point recognition +namespace: biological_process +def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] +is_a: GO:0016198 ! axon choice point recognition + +[Term] +id: GO:0016200 +name: synaptic target attraction +namespace: biological_process +def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0008039 ! synaptic target recognition + +[Term] +id: GO:0016201 +name: synaptic target inhibition +namespace: biological_process +def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0008039 ! synaptic target recognition + +[Term] +id: GO:0016202 +name: regulation of striated muscle tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] +is_a: GO:0048634 ! regulation of muscle organ development +is_a: GO:1901861 ! regulation of muscle tissue development +relationship: regulates GO:0014706 ! striated muscle tissue development + +[Term] +id: GO:0016203 +name: muscle attachment +namespace: biological_process +def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0060538 ! skeletal muscle organ development + +[Term] +id: GO:0016204 +name: determination of muscle attachment site +namespace: biological_process +def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0016203 ! muscle attachment + +[Term] +id: GO:0016205 +name: selenocysteine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.280, PMID:10026151] +xref: EC:2.1.1.280 +xref: MetaCyc:RXN-11061 +xref: RHEA:26341 +is_a: GO:0051995 ! Se-methyltransferase activity + +[Term] +id: GO:0016206 +name: catechol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] +synonym: "catechol methyltransferase activity" RELATED [EC:2.1.1.6] +synonym: "catecholamine O-methyltransferase activity" RELATED [EC:2.1.1.6] +synonym: "COMT I" RELATED [EC:2.1.1.6] +synonym: "COMT II" RELATED [EC:2.1.1.6] +synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] +synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" RELATED [EC:2.1.1.6] +synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] +xref: EC:2.1.1.6 +xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ" +xref: Reactome:R-HSA-8955010 "LRTOMT transfers Met to DA, forming 3MT" +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016207 +name: 4-coumarate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] +synonym: "4-coumarate-CoA synthetase activity" EXACT [] +synonym: "4-coumarate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.12] +synonym: "4-coumarate:CoA ligase activity" EXACT [] +synonym: "4-coumarate:coenzyme A ligase activity" RELATED [EC:6.2.1.12] +synonym: "4-coumaroyl-CoA synthase activity" RELATED [EC:6.2.1.12] +synonym: "4-coumaroyl-CoA synthetase activity" RELATED [EC:6.2.1.12] +synonym: "4-coumaryl-CoA synthetase activity" RELATED [EC:6.2.1.12] +synonym: "4CL" RELATED [EC:6.2.1.12] +synonym: "caffeolyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12] +synonym: "feruloyl CoA ligase activity" RELATED [EC:6.2.1.12] +synonym: "feruloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12] +synonym: "hydroxycinnamate:CoA ligase activity" RELATED [EC:6.2.1.12] +synonym: "hydroxycinnamoyl CoA synthetase activity" RELATED [EC:6.2.1.12] +synonym: "p-coumaroyl CoA ligase activity" RELATED [EC:6.2.1.12] +synonym: "p-coumaryl coenzyme A synthetase activity" RELATED [EC:6.2.1.12] +synonym: "p-coumaryl-CoA ligase activity" RELATED [EC:6.2.1.12] +synonym: "p-coumaryl-CoA synthetase activity" RELATED [EC:6.2.1.12] +synonym: "p-hydroxycinnamic acid:CoA ligase activity" RELATED [EC:6.2.1.12] +synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12] +synonym: "sinapoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.12] +xref: EC:6.2.1.12 +xref: KEGG_REACTION:R01616 +xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN +xref: RHEA:19641 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0016208 +name: AMP binding +namespace: molecular_function +def: "Binding to AMP, adenosine monophosphate." [GOC:go_curators] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0016209 +name: antioxidant activity +namespace: molecular_function +def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0016210 +name: naringenin-chalcone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] +synonym: "DOCS" NARROW [] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] +xref: EC:2.3.1.74 +xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN +xref: RHEA:11128 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016211 +name: ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] +xref: EC:6.3.1.- +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0016212 +name: kynurenine-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] +synonym: "kynurenine 2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.7] +synonym: "kynurenine aminotransferase activity" BROAD [EC:2.6.1.7] +synonym: "kynurenine transaminase (cyclizing)" RELATED [EC:2.6.1.7] +synonym: "kynurenine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.7] +synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] +synonym: "L-kynurenine aminotransferase activity" RELATED [EC:2.6.1.7] +synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.7] +xref: EC:2.6.1.7 +xref: MetaCyc:2.6.1.7-RXN +xref: Reactome:R-HSA-893583 "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate" +xref: Reactome:R-HSA-893596 "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu" +xref: Reactome:R-HSA-901097 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]" +xref: RHEA:20964 +is_a: GO:0036137 ! kynurenine aminotransferase activity + +[Term] +id: GO:0016213 +name: linoleoyl-CoA desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [PMID:12713571, PMID:7212717, RHEA:47140] +comment: Note that this function was formerly EC:1.14.99.25. +synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] +synonym: "delta(6)-desaturase activity" BROAD [] +synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] +synonym: "delta6-acyl CoA desaturase activity" RELATED [EC:1.14.19.3] +synonym: "delta6-desaturase activity" RELATED [EC:1.14.19.3] +synonym: "delta6-fatty acyl-CoA desaturase activity" RELATED [EC:1.14.19.3] +synonym: "fatty acid 6-desaturase activity" BROAD [] +synonym: "fatty acid delta(6)-desaturase activity" BROAD [] +synonym: "fatty acid delta6-desaturase activity" RELATED [EC:1.14.19.3] +synonym: "linoleate desaturase activity" RELATED [] +synonym: "linoleic acid desaturase activity" RELATED [] +synonym: "linoleic desaturase activity" RELATED [] +synonym: "linoleoyl CoA desaturase activity" EXACT [] +synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] +synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] +synonym: "long-chain fatty acid delta6-desaturase activity" RELATED [EC:1.14.19.3] +xref: EC:1.14.19.3 +xref: MetaCyc:1.14.19.3-RXN +xref: Reactome:R-HSA-2046084 "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA" +xref: Reactome:R-HSA-2046096 "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA" +xref: Reactome:R-HSA-2046097 "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA" +xref: Reactome:R-HSA-2046099 "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA" +xref: RHEA:47140 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0016215 +name: acyl-CoA desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [GOC:mah] +synonym: "CoA desaturase activity" BROAD [] +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0016216 +name: isopenicillin-N synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22428] +synonym: "isopenicillin N synthase activity" RELATED [EC:1.21.3.1] +synonym: "isopenicillin-N synthetase activity" EXACT [] +synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.21.3.1] +xref: EC:1.21.3.1 +xref: KEGG_REACTION:R04872 +xref: MetaCyc:1.21.3.1-RXN +xref: RHEA:22428 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0016217 +name: N-ethylammeline chlorohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN] +xref: MetaCyc:R465-RXN +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0016218 +name: obsolete polyketide synthase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] +comment: This term was made obsolete because the activity it describes does not exist, and the gene product with the name 'polyketide synthase' has multiple functional domains, so using the name to describe a single function would be misleading. +synonym: "polyketide synthase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030639 +consider: GO:0034081 + +[Term] +id: GO:0016222 +name: procollagen-proline 4-dioxygenase complex +namespace: cellular_component +def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] +synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" RELATED [EC:1.14.11.2] +synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0016223 +name: beta-alanine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] +synonym: "beta-alanine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.18] +synonym: "beta-alanine-alpha-alanine transaminase activity" RELATED [EC:2.6.1.18] +synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] +synonym: "L-alanine:3-oxopropanoate aminotransferase activity" RELATED [EC:2.6.1.18] +synonym: "omega-amino acid--pyruvate aminotransferase activity" RELATED [EC:2.6.1.18] +xref: EC:2.6.1.18 +xref: MetaCyc:2.6.1.18-RXN +xref: Reactome:R-HSA-909776 "beta-alanine + pyruvate => 3-oxopropanoate + alanine" +xref: RHEA:14077 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0016226 +name: iron-sulfur cluster assembly +namespace: biological_process +def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] +subset: goslim_metagenomics +subset: goslim_pombe +synonym: "iron-sulfur cluster biosynthesis" RELATED [] +synonym: "iron-sulphur cluster assembly" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0016227 +name: obsolete tRNA sulfurtransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] +comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly +synonym: "L-cysteine:tRNA sulfurtransferase activity" RELATED [EC:2.8.1.4] +synonym: "ribonucleate sulfurtransferase activity" RELATED [EC:2.8.1.4] +synonym: "RNA sulfurtransferase activity" RELATED [EC:2.8.1.4] +synonym: "transfer ribonucleate sulfurtransferase activity" RELATED [EC:2.8.1.4] +synonym: "transfer RNA sulfurtransferase activity" RELATED [EC:2.8.1.4] +synonym: "transfer RNA thiolase activity" RELATED [EC:2.8.1.4] +synonym: "tRNA sulfurtransferase activity" EXACT [] +synonym: "tRNA sulphurtransferase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0034227 +consider: GO:0016783 + +[Term] +id: GO:0016229 +name: steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016230 +name: sphingomyelin phosphodiesterase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] +synonym: "neutral sphingomyelinase activator" EXACT [] +is_a: GO:0016004 ! phospholipase activator activity + +[Term] +id: GO:0016231 +name: beta-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] +is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity + +[Term] +id: GO:0016232 +name: HNK-1 sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973] +synonym: "HNK-1 sulphotransferase activity" EXACT [] +xref: Reactome:R-HSA-6786048 "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0016233 +name: telomere capping +namespace: biological_process +def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] +synonym: "telomere end protection" EXACT [] +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0016234 +name: inclusion body +namespace: cellular_component +def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] +synonym: "cellular inclusion" RELATED [NIF_Subcellular:sao120573470] +synonym: "neuronal cytoplasmic inclusion" NARROW [] +xref: NIF_Subcellular:sao120573470 +xref: Wikipedia:Inclusion_bodies +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0016235 +name: aggresome +namespace: cellular_component +def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] +xref: Wikipedia:Aggresome +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0016236 +name: macroautophagy +namespace: biological_process +alt_id: GO:0034262 +def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] +comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. +synonym: "autophagy" BROAD [] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0016237 +name: lysosomal microautophagy +namespace: biological_process +def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0016239 +name: positive regulation of macroautophagy +namespace: biological_process +def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] +synonym: "activation of macroautophagy" NARROW [] +synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "stimulation of macroautophagy" NARROW [] +synonym: "up regulation of macroautophagy" EXACT [] +synonym: "up-regulation of macroautophagy" EXACT [] +synonym: "upregulation of macroautophagy" EXACT [] +is_a: GO:0010508 ! positive regulation of autophagy +is_a: GO:0016241 ! regulation of macroautophagy +relationship: positively_regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016240 +name: autophagosome membrane docking +namespace: biological_process +def: "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah] +synonym: "autophagic vacuole docking" EXACT [GOC:autophagy] +is_a: GO:0140056 ! organelle localization by membrane tethering +relationship: part_of GO:0097352 ! autophagosome maturation + +[Term] +id: GO:0016241 +name: regulation of macroautophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] +synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010506 ! regulation of autophagy +relationship: regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016242 +name: negative regulation of macroautophagy +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] +synonym: "down regulation of macroautophagy" EXACT [] +synonym: "down-regulation of macroautophagy" EXACT [] +synonym: "downregulation of macroautophagy" EXACT [] +synonym: "inhibition of macroautophagy" NARROW [] +synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010507 ! negative regulation of autophagy +is_a: GO:0016241 ! regulation of macroautophagy +relationship: negatively_regulates GO:0016236 ! macroautophagy + +[Term] +id: GO:0016243 +name: regulation of autophagosome size +namespace: biological_process +def: "Any process that modulates the size of the autophagosome." [GOC:autophagy, GOC:krc] +synonym: "regulation of autophagic vacuole size" EXACT [GOC:autophagy] +is_a: GO:0032535 ! regulation of cellular component size +is_a: GO:1905037 ! autophagosome organization + +[Term] +id: GO:0016246 +name: RNA interference +namespace: biological_process +def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] +comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. +synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] +synonym: "RNAi" EXACT [] +xref: Wikipedia:RNA_interference +is_a: GO:0035194 ! post-transcriptional gene silencing by RNA + +[Term] +id: GO:0016247 +name: channel regulator activity +namespace: molecular_function +def: "Bonds to and modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0016248 +name: channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a channel." [GOC:mah] +is_a: GO:0016247 ! channel regulator activity +is_a: GO:0140678 ! molecular function inhibitor activity + +[Term] +id: GO:0016250 +name: N-sulfoglucosamine sulfohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1] +synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" RELATED [EC:3.10.1.1] +synonym: "heparin sulfamidase activity" RELATED [EC:3.10.1.1] +synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" RELATED [EC:3.10.1.1] +synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] +synonym: "sulfoglucosamine sulfamidase activity" RELATED [EC:3.10.1.1] +synonym: "sulphamidase activity" RELATED [EC:3.10.1.1] +xref: EC:3.10.1.1 +xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN +xref: Reactome:R-HSA-1678708 "SGSH hydrolyses Heparan sulfate chain(2)" +xref: Reactome:R-HSA-2090043 "SGSH hydrolyses Heparan sulfate chain(7)" +xref: Reactome:R-HSA-2263444 "Defective SGSH does not hydrolyse Heparan sulfate chain(7)" +xref: Reactome:R-HSA-9036050 "Defective SGSH does not hydrolyse Heparan sulfate chain(2)" +xref: RHEA:17881 +is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds + +[Term] +id: GO:0016251 +name: RNA polymerase II general transcription initiation factor activity +namespace: molecular_function +alt_id: GO:0000983 +alt_id: GO:0001075 +alt_id: GO:0003703 +def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126] +comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur. +synonym: "basal RNA polymerase II transcription factor activity" EXACT [] +synonym: "general RNA polymerase II transcription factor activity" EXACT [] +synonym: "GTF2 activity" EXACT [] +synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED [] +synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED [] +synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED [] +synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED [] +synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED [] +is_a: GO:0140223 ! general transcription initiation factor activity + +[Term] +id: GO:0016252 +name: obsolete nonspecific RNA polymerase II transcription factor activity +namespace: molecular_function +def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] +comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "nonspecific RNA polymerase II transcription factor activity" EXACT [] +is_obsolete: true +consider: GO:0006366 +consider: GO:0016251 + +[Term] +id: GO:0016254 +name: preassembly of GPI anchor in ER membrane +namespace: biological_process +def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595] +synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +relationship: part_of GO:0006506 ! GPI anchor biosynthetic process + +[Term] +id: GO:0016255 +name: attachment of GPI anchor to protein +namespace: biological_process +def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] +is_a: GO:0006464 ! cellular protein modification process +relationship: part_of GO:0006506 ! GPI anchor biosynthetic process + +[Term] +id: GO:0016256 +name: N-glycan processing to lysosome +namespace: biological_process +def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595] +is_a: GO:0006491 ! N-glycan processing +relationship: part_of GO:0006622 ! protein targeting to lysosome + +[Term] +id: GO:0016257 +name: N-glycan processing to secreted and cell-surface N-glycans +namespace: biological_process +def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595] +is_a: GO:0006491 ! N-glycan processing + +[Term] +id: GO:0016258 +name: N-glycan diversification +namespace: biological_process +def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595] +is_a: GO:0006491 ! N-glycan processing + +[Term] +id: GO:0016259 +name: selenocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] +synonym: "selenocysteine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process + +[Term] +id: GO:0016260 +name: selenocysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] +synonym: "selenocysteine anabolism" EXACT [] +synonym: "selenocysteine biosynthesis" EXACT [] +synonym: "selenocysteine formation" EXACT [] +synonym: "selenocysteine synthesis" EXACT [] +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:0016261 +name: selenocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] +synonym: "selenocysteine breakdown" EXACT [] +synonym: "selenocysteine catabolism" EXACT [] +synonym: "selenocysteine degradation" EXACT [] +is_a: GO:0009071 ! serine family amino acid catabolic process +is_a: GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:0016262 +name: protein N-acetylglucosaminyltransferase activity +namespace: molecular_function +alt_id: GO:0016253 +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] +synonym: "N-GlcNAc transferase activity" RELATED [EC:2.4.1.94] +synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] +synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] +xref: EC:2.4.1.94 +xref: MetaCyc:2.4.1.94-RXN +xref: RHEA:16533 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0016263 +name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] +synonym: "Core 1 GalT" RELATED [] +synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.122] +synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.122] +synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" RELATED [EC:2.4.1.122] +xref: EC:2.4.1.122 +xref: MetaCyc:2.4.1.122-RXN +xref: Reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)" +xref: Reactome:R-HSA-6785524 "Defective C1GALT1C1 does not bind C1GALT1" +xref: RHEA:15621 +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0016264 +name: gap junction assembly +namespace: biological_process +def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363] +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0016265 +name: obsolete death +namespace: biological_process +def: "OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099] +comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. +xref: Wikipedia:Death +is_obsolete: true +consider: GO:0008219 +consider: GO:0012501 + +[Term] +id: GO:0016266 +name: O-glycan processing +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0006493 ! protein O-linked glycosylation + +[Term] +id: GO:0016267 +name: O-glycan processing, core 1 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016268 +name: O-glycan processing, core 2 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016269 +name: O-glycan processing, core 3 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016270 +name: O-glycan processing, core 4 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0016271 +name: obsolete tissue death +namespace: biological_process +def: "OBSOLETE. A permanent cessation of all vital functions of a tissue." [GOC:dph, GOC:mtg_apoptosis] +comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. +is_obsolete: true +consider: GO:0008219 +consider: GO:0012501 + +[Term] +id: GO:0016272 +name: prefoldin complex +namespace: cellular_component +def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] +synonym: "GIM complex" NARROW [] +xref: Wikipedia:Prefoldin +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0016273 +name: arginine N-methyltransferase activity +namespace: molecular_function +def: "Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016274 +name: protein-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636, PMID:31284549] +synonym: "PRMT activity" EXACT [] +xref: Reactome:R-HSA-191790 "Loading and methylation of Sm proteins onto SMN Complexes" +xref: Reactome:R-HSA-5205798 "PRMT1,PRMT6 methylate arginine-4 of histone H4" +xref: Reactome:R-HSA-5205820 "PRMT6 methylates arginine-4 of histone H2A (H2AR3)" +xref: Reactome:R-HSA-5205822 "CARM1 methylates arginine-18 (H3R17) of histone H3" +xref: Reactome:R-HSA-5205824 "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)" +xref: Reactome:R-HSA-5205867 "PRMT1 methylates arginine-12 of histone H2A (H2AR11)" +xref: Reactome:R-HSA-5218952 "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)" +xref: Reactome:R-HSA-5229010 "CARM1 methylates arginine-27 of histone H3 (H3R26)" +xref: Reactome:R-HSA-5229203 "PRMT6 methylates histone H2A arginine-30 (H2AR29)" +xref: Reactome:R-HSA-5661126 "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4" +xref: Reactome:R-HSA-8879123 "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2" +xref: Reactome:R-HSA-8934735 "PRMT1 arginine-methylates RUNX1" +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0016273 ! arginine N-methyltransferase activity + +[Term] +id: GO:0016275 +name: [cytochrome c]-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] +synonym: "cytochrome c-arginine N-methyltransferase activity" RELATED [EC:2.1.1.124] +synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] +synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] +xref: EC:2.1.1.124 +xref: MetaCyc:2.1.1.124-RXN +xref: RHEA:21872 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0016277 +name: [myelin basic protein]-arginine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [PMID:6177833] +synonym: "myelin basic protein methylase activity" RELATED [EC:2.1.1.126] +synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] +synonym: "myelin basic protein-arginine N-methyltransferase activity" RELATED [EC:2.1.1.126] +synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] +synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" RELATED [EC:2.1.1.126] +synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" RELATED [EC:2.1.1.126] +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0016278 +name: lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] +xref: Reactome:R-HSA-3222237 "SMYD2 methylates TP53" +xref: Reactome:R-HSA-6805730 "SETD9 methylates TP53" +xref: Reactome:R-HSA-6805740 "SETD8 methylates TP53" +xref: Reactome:R-HSA-6805755 "EHMT1:EHMT2 dimethylates TP53" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016279 +name: protein-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] +xref: Reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27" +xref: Reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex" +xref: Reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB" +xref: Reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A" +xref: Reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8" +xref: Reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2" +xref: Reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN" +xref: Reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP" +xref: Reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1" +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0016278 ! lysine N-methyltransferase activity + +[Term] +id: GO:0016281 +name: eukaryotic translation initiation factor 4F complex +namespace: cellular_component +def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919] +synonym: "eIF-4F" EXACT [] +synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0016282 +name: eukaryotic 43S preinitiation complex +namespace: cellular_component +def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] +synonym: "eukaryotic 43S pre-initiation complex" EXACT [] +is_a: GO:0070993 ! translation preinitiation complex + +[Term] +id: GO:0016284 +name: obsolete alanine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +synonym: "alanine aminopeptidase activity" EXACT [] +xref: EC:3.4.11.- +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0016285 +name: obsolete cytosol alanyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] +comment: This term was made obsolete because it represents a gene product and refers to cellular component information. +synonym: "aminopolypeptidase activity" RELATED [EC:3.4.11.14] +synonym: "arylamidase activity" NARROW [EC:3.4.11.14] +synonym: "cytosol alanyl aminopeptidase activity" EXACT [] +synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] +synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] +synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] +synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] +synonym: "soluble alanyl aminopeptidase activity" RELATED [EC:3.4.11.14] +synonym: "thiol-activated aminopeptidase activity" RELATED [EC:3.4.11.14] +xref: EC:3.4.11.14 +xref: MetaCyc:3.4.11.14-RXN +is_obsolete: true +consider: GO:0004177 +consider: GO:0008235 + +[Term] +id: GO:0016286 +name: small conductance calcium-activated potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] +synonym: "SK calcium-activated potassium channel activity" EXACT [] +synonym: "SK KCa channels" EXACT [] +synonym: "small conductance KCa channels" EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0016287 +name: glycerone-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17657] +synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" RELATED [EC:2.3.1.42] +synonym: "dihydroxyacetone phosphate acyltransferase activity" RELATED [EC:2.3.1.42] +xref: EC:2.3.1.42 +xref: KEGG_REACTION:R01013 +xref: MetaCyc:2.3.1.42-RXN +xref: Reactome:R-HSA-1483002 "DHAP is converted to 1-acyl GO3P by GNPAT" +xref: Reactome:R-HSA-75879 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH" +xref: RHEA:17657 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0016289 +name: CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] +xref: Reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH" +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0016290 +name: palmitoyl-CoA hydrolase activity +namespace: molecular_function +alt_id: GO:0016293 +def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +subset: goslim_chembl +synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] +synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD [] +synonym: "palmitoyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.2] +synonym: "palmitoyl thioesterase activity" RELATED [EC:3.1.2.2] +synonym: "palmitoyl-CoA deacylase activity" RELATED [EC:3.1.2.2] +synonym: "palmityl thioesterase activity" RELATED [EC:3.1.2.2] +synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] +synonym: "palmityl-CoA deacylase activity" RELATED [EC:3.1.2.2] +xref: EC:3.1.2.2 +xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN +xref: MetaCyc:PWY-5148 +xref: RHEA:16645 +is_a: GO:0047617 ! acyl-CoA hydrolase activity + +[Term] +id: GO:0016295 +name: myristoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727] +synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "myristoyl-ACP hydrolase activity" EXACT [] +synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] +synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] +xref: EC:3.1.2.14 +xref: KEGG_REACTION:R08159 +xref: MetaCyc:RXN-10727 +xref: RHEA:30123 +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0016296 +name: palmitoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549] +synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "palmitoyl-ACP hydrolase activity" EXACT [] +xref: EC:3.1.2.14 +xref: KEGG_REACTION:R08162 +xref: MetaCyc:RXN-9549 +xref: RHEA:41932 +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0016297 +name: acyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +alt_id: GO:0010281 +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902] +synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "acyl-ACP hydrolase activity" EXACT [] +synonym: "acyl-ACP thioesterase activity" EXACT [] +synonym: "acyl-ACP-hydrolase activity" RELATED [EC:3.1.2.14] +synonym: "acyl-acyl carrier protein hydrolase activity" RELATED [EC:3.1.2.14] +synonym: "acyl-acyl-carrier-protein hydrolase activity" RELATED [EC:3.1.2.14] +synonym: "S-acyl fatty acid synthase thioesterase activity" RELATED [EC:3.1.2.14] +xref: EC:3.1.2.14 +xref: MetaCyc:RXN-7902 +xref: Reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer" +xref: RHEA:30131 +is_a: GO:0004312 ! fatty acid synthase activity +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0016298 +name: lipase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] +subset: goslim_aspergillus +subset: goslim_chembl +subset: goslim_drosophila +xref: EC:3.1.1.- +xref: Reactome:R-HSA-163402 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid" +xref: Reactome:R-HSA-163432 "cholesterol ester + H2O -> cholesterol + fatty acid" +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0016299 +name: obsolete regulator of G-protein signaling activity +namespace: molecular_function +def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators] +comment: This term was made obsolete because it refers to a combination of a function and a process. +synonym: "regulator of G protein signaling activity" EXACT [] +synonym: "regulator of G protein signalling activity" EXACT [] +synonym: "regulator of G-protein signaling activity" EXACT [] +synonym: "regulator of G-protein signalling activity" EXACT [] +synonym: "RGS" EXACT [] +is_obsolete: true +consider: GO:0005095 +consider: GO:0034260 +consider: GO:0045744 + +[Term] +id: GO:0016300 +name: tRNA (uracil) methyltransferase activity +namespace: molecular_function +alt_id: GO:0016431 +def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] +comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). +synonym: "tRNA (uridine) methyltransferase activity" EXACT [] +is_a: GO:0008175 ! tRNA methyltransferase activity + +[Term] +id: GO:0016301 +name: kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] +comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_plant +subset: goslim_yeast +synonym: "phosphokinase activity" EXACT [] +xref: Reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" +xref: Reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016303 +name: 1-phosphatidylinositol-3-kinase activity +namespace: molecular_function +alt_id: GO:0004429 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12709] +synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" RELATED [EC:2.7.1.137] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "PI3-kinase activity" RELATED [EC:2.7.1.137] +synonym: "PI3K" EXACT [] +synonym: "PtdIns-3-kinase activity" RELATED [EC:2.7.1.137] +synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] +synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] +synonym: "Vps34p" RELATED [EC:2.7.1.137] +xref: EC:2.7.1.137 +xref: KEGG_REACTION:R03362 +xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN +xref: Reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3" +xref: Reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane" +xref: Reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane" +xref: Reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane" +xref: Reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns" +xref: Reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P" +xref: RHEA:12709 +is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity +is_a: GO:0052742 ! phosphatidylinositol kinase activity + +[Term] +id: GO:0016304 +name: obsolete phosphatidylinositol 3-kinase activity, class I +namespace: molecular_function +def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "phosphatidylinositol 3-kinase activity, class I" EXACT [] +is_obsolete: true +consider: GO:0016303 +consider: GO:0035005 +consider: GO:0046934 + +[Term] +id: GO:0016305 +name: obsolete phosphatidylinositol 3-kinase activity, class II +namespace: molecular_function +def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "phosphatidylinositol 3-kinase activity, class II" EXACT [] +synonym: "PI3KC2" EXACT [] +is_obsolete: true +consider: GO:0016303 +consider: GO:0035005 +consider: GO:0046934 + +[Term] +id: GO:0016306 +name: obsolete phosphatidylinositol 3-kinase activity, class III +namespace: molecular_function +def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "phosphatidylinositol 3-kinase activity, class III" EXACT [] +is_obsolete: true +replaced_by: GO:0016303 + +[Term] +id: GO:0016307 +name: phosphatidylinositol phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] +synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0016308 +name: 1-phosphatidylinositol-4-phosphate 5-kinase activity +namespace: molecular_function +alt_id: GO:0004431 +alt_id: GO:0045215 +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14425] +synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] +synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.68] +synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] +synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] +synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" RELATED [EC:2.7.1.68] +synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] +synonym: "PIP5K" EXACT [] +synonym: "PtdIns(4)P-5-kinase activity" RELATED [EC:2.7.1.68] +synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] +xref: EC:2.7.1.68 +xref: KEGG_REACTION:R03469 +xref: MetaCyc:2.7.1.68-RXN +xref: Reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane" +xref: Reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2" +xref: Reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2" +xref: RHEA:14425 +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0016309 +name: 1-phosphatidylinositol-5-phosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] +synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" RELATED [EC:2.7.1.149] +synonym: "PIP4K" EXACT [] +synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] +xref: EC:2.7.1.149 +xref: MetaCyc:2.7.1.149-RXN +xref: Reactome:R-HSA-1675776 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane" +xref: Reactome:R-HSA-6811522 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus" +xref: RHEA:12280 +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0016310 +name: phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] +subset: goslim_chembl +subset: goslim_metagenomics +xref: Wikipedia:Phosphorylation +is_a: GO:0006796 ! phosphate-containing compound metabolic process + +[Term] +id: GO:0016311 +name: dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] +xref: Wikipedia:Dephosphorylation +is_a: GO:0006796 ! phosphate-containing compound metabolic process + +[Term] +id: GO:0016312 +name: inositol bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb] +xref: Reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7" +xref: Reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9" +xref: RHEA:57840 +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0016313 +name: obsolete inositol-1,4,5-trisphosphate phosphatase +namespace: molecular_function +def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb] +comment: This term was made obsolete because it is a redundant grouping term with only one child. +synonym: "inositol-1,4,5-trisphosphate phosphatase" EXACT [] +is_obsolete: true +consider: GO:0046030 + +[Term] +id: GO:0016314 +name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] +synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.67] +synonym: "MMAC1" RELATED [EC:3.1.3.67] +synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" RELATED [EC:3.1.3.67] +synonym: "PI(3)P 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] +synonym: "PI(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] +synonym: "PtdIns(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] +xref: EC:3.1.3.67 +xref: MetaCyc:3.1.3.67-RXN +xref: Reactome:R-HSA-199456 "PTEN dephosphorylates PIP3" +xref: Reactome:R-HSA-202237 "Hydrolysis of PIP3 to PI(3,4)P2" +xref: Reactome:R-HSA-2317387 "PTEN cancer mutants do not dephosphorylate PIP3" +xref: RHEA:25017 +is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity + +[Term] +id: GO:0016316 +name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity +namespace: molecular_function +alt_id: GO:0004440 +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] +synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" RELATED [EC:3.1.3.66] +synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] +xref: EC:3.1.3.66 +xref: MetaCyc:3.1.3.66-RXN +xref: Reactome:R-HSA-1676162 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane" +xref: Reactome:R-HSA-1676164 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane" +is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity +is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity + +[Term] +id: GO:0016318 +name: ommatidial rotation +namespace: biological_process +def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity + +[Term] +id: GO:0016319 +name: mushroom body development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0016320 +name: endoplasmic reticulum membrane fusion +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid] +synonym: "ER membrane fusion" EXACT [] +is_a: GO:0007029 ! endoplasmic reticulum organization +is_a: GO:0090158 ! endoplasmic reticulum membrane organization +is_a: GO:0090174 ! organelle membrane fusion + +[Term] +id: GO:0016321 +name: female meiosis chromosome segregation +namespace: biological_process +def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045132 ! meiotic chromosome segregation +relationship: part_of GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0016322 +name: neuron remodeling +namespace: biological_process +def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] +synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091] +synonym: "neuronal remodeling" EXACT [] +is_a: GO:0042551 ! neuron maturation + +[Term] +id: GO:0016323 +name: basolateral plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0009925 ! basal plasma membrane + +[Term] +id: GO:0016324 +name: apical plasma membrane +namespace: cellular_component +def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0016325 +name: oocyte microtubule cytoskeleton organization +namespace: biological_process +alt_id: GO:0048130 +def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] +synonym: "oocyte microtubule cytoskeleton organisation" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity +relationship: part_of GO:0007308 ! oocyte construction + +[Term] +id: GO:0016326 +name: obsolete kinesin motor activity +namespace: molecular_function +def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb] +comment: This term was made obsolete because it represents a gene product. +synonym: "kinesin motor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0003777 + +[Term] +id: GO:0016327 +name: apicolateral plasma membrane +namespace: cellular_component +def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] +synonym: "apical lateral plasma membrane" EXACT [PMID:24496625] +is_a: GO:0098590 ! plasma membrane region + +[Term] +id: GO:0016328 +name: lateral plasma membrane +namespace: cellular_component +def: "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0016329 +name: obsolete apoptosis regulator activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl] +comment: This term was made obsolete because it represents involvement in a biological process. +synonym: "apoptosis regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0042981 + +[Term] +id: GO:0016330 +name: second mitotic wave involved in compound eye morphogenesis +namespace: biological_process +def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] +synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000278 ! mitotic cell cycle +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0016331 +name: morphogenesis of embryonic epithelium +namespace: biological_process +def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0016332 +name: establishment or maintenance of polarity of embryonic epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium + +[Term] +id: GO:0016333 +name: morphogenesis of follicular epithelium +namespace: biological_process +def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0016334 +name: establishment or maintenance of polarity of follicular epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium + +[Term] +id: GO:0016335 +name: morphogenesis of larval imaginal disc epithelium +namespace: biological_process +def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0002168 ! instar larval development +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0016336 +name: establishment or maintenance of polarity of larval imaginal disc epithelium +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium + +[Term] +id: GO:0016338 +name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-independent cell adhesion molecule activity" RELATED [] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules + +[Term] +id: GO:0016339 +name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] +synonym: "calcium-dependent cell adhesion molecule activity" RELATED [] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules + +[Term] +id: GO:0016340 +name: calcium-dependent cell-matrix adhesion +namespace: biological_process +def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0016341 +name: obsolete other collagen +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a redundant grouping term. +synonym: "other collagen" EXACT [] +is_obsolete: true +replaced_by: GO:0005581 + +[Term] +id: GO:0016342 +name: catenin complex +namespace: cellular_component +def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0019897 ! extrinsic component of plasma membrane + +[Term] +id: GO:0016343 +name: obsolete cytoskeletal anchoring activity +namespace: molecular_function +def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] +comment: This term was made obsolete because it represents a biological process. +synonym: "cytoskeletal anchoring activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016344 +name: meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] +synonym: "chromosome migration to spindle pole during meiosis" EXACT [] +synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] +synonym: "meiotic chromosome movement" BROAD [] +synonym: "meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0051305 ! chromosome movement towards spindle pole +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0016345 +name: female meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] +synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] +synonym: "female meiotic chromosome movement" BROAD [] +synonym: "female meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0016321 ! female meiosis chromosome segregation + +[Term] +id: GO:0016346 +name: male meiotic chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] +synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] +synonym: "male meiotic chromosome movement" BROAD [] +synonym: "male meiotic chromosome movement to spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007060 ! male meiosis chromosome segregation + +[Term] +id: GO:0016347 +name: obsolete calcium-independent cell adhesion molecule activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "calcium-independent cell adhesion molecule activity" EXACT [] +is_obsolete: true +consider: GO:0005515 +consider: GO:0007161 +consider: GO:0016021 +consider: GO:0016338 + +[Term] +id: GO:0016348 +name: imaginal disc-derived leg joint morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0036011 ! imaginal disc-derived leg segmentation + +[Term] +id: GO:0016351 +name: obsolete drug susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "drug susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0009410 + +[Term] +id: GO:0016352 +name: obsolete insecticide susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "insecticide susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0017085 + +[Term] +id: GO:0016353 +name: obsolete carbamate susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "carbamate susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046681 + +[Term] +id: GO:0016354 +name: obsolete cyclodiene susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "cyclodiene susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046682 + +[Term] +id: GO:0016355 +name: obsolete DDT susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. +synonym: "DDT susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046680 + +[Term] +id: GO:0016356 +name: obsolete organophosphorus susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "organophosphorus susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046683 + +[Term] +id: GO:0016357 +name: obsolete pyrethroid susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "pyrethroid susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046684 + +[Term] +id: GO:0016358 +name: dendrite development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] +is_a: GO:0031175 ! neuron projection development +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0016360 +name: sensory organ precursor cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph] +is_a: GO:0060582 ! cell fate determination involved in pattern specification +relationship: part_of GO:0008052 ! sensory organ boundary specification + +[Term] +id: GO:0016361 +name: activin receptor activity, type I +namespace: molecular_function +def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] +synonym: "type I activin receptor activity" EXACT [] +is_a: GO:0017002 ! activin-activated receptor activity + +[Term] +id: GO:0016362 +name: activin receptor activity, type II +namespace: molecular_function +def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651] +synonym: "type II activin receptor activity" EXACT [] +xref: Reactome:R-HSA-201443 "Type II receptor phosphorylates type I receptor" +is_a: GO:0017002 ! activin-activated receptor activity + +[Term] +id: GO:0016363 +name: nuclear matrix +namespace: cellular_component +def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] +synonym: "nucleoskeleton" EXACT [] +xref: Wikipedia:Nuclear_matrix +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0034399 ! nuclear periphery + +[Term] +id: GO:0016401 +name: palmitoyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg] +xref: EC:1.3.3.- +is_a: GO:0003997 ! acyl-CoA oxidase activity + +[Term] +id: GO:0016402 +name: pristanoyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg, RHEA:40459] +xref: Reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA" +xref: Reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)" +xref: RHEA:40459 +is_a: GO:0003997 ! acyl-CoA oxidase activity + +[Term] +id: GO:0016403 +name: dimethylargininase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] +synonym: "dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18] +synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18] +synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" RELATED [EC:3.5.3.18] +synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" RELATED [EC:3.5.3.18] +xref: EC:3.5.3.18 +xref: MetaCyc:DIMETHYLARGININASE-RXN +xref: Reactome:R-HSA-5693373 "DDAH1,2 hydrolyses ADMA to DMA and L-Cit" +xref: RHEA:17305 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016404 +name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] +synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" RELATED [EC:1.1.1.141] +synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" RELATED [EC:1.1.1.141] +synonym: "15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141] +synonym: "15-hydroxyprostanoic dehydrogenase activity" RELATED [EC:1.1.1.141] +synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] +synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" RELATED [EC:1.1.1.141] +synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141] +synonym: "prostaglandin dehydrogenase activity" RELATED [EC:1.1.1.141] +xref: EC:1.1.1.141 +xref: MetaCyc:1.1.1.141-RXN +xref: Reactome:R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD" +xref: Reactome:R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD" +xref: Reactome:R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1" +xref: Reactome:R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1" +xref: RHEA:11876 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016405 +name: CoA-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] +xref: Reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate" +xref: Reactome:R-HSA-159567 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate" +xref: Reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate" +xref: Reactome:R-HSA-6798345 "PXLP-GCAT dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA" +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0016406 +name: carnitine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016407 +name: acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] +synonym: "acetylase activity" EXACT [] +xref: Reactome:R-HSA-5628871 "BRD7 promotes EP300-mediated acetylation of TP53" +xref: Reactome:R-HSA-5660660 "p300 acetylates RELA subunit" +xref: Reactome:R-HSA-5682044 "KAT5 acetylates ATM at DNA DSBs" +xref: Reactome:R-HSA-6792712 "KAT5 acetylates ATM at shortened telomeres" +xref: Reactome:R-HSA-6805638 "KAT6A acetylates TP53" +xref: Reactome:R-HSA-73736 "Acetylation of SL1" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016408 +name: C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016409 +name: palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-203567 "palmitoylation of eNOS" +xref: Reactome:R-HSA-5686304 "ZDHHC2 transfers PALM from PALM-CoA to CKAP4" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016410 +name: N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-177160 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016411 +name: acylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] +xref: Reactome:R-HSA-1482647 "2-MAG and DAG are transacylated to TAG by PNPLA2/3" +xref: Reactome:R-HSA-1482654 "2-MAG is transacylated to DAG by PNPLA2/3" +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016412 +name: serine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] +xref: EC:2.3.1.30 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0016413 +name: O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0016414 +name: O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016415 ! octanoyltransferase activity + +[Term] +id: GO:0016415 +name: octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] +xref: EC:2.3.1.181 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016416 +name: O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-2404137 "LRAT esterifies RBP1:atROL and FACYLs to atREs" +xref: Reactome:R-HSA-2453855 "LRAT esterifies RBP1:atROL and FACYLs to atREs" +xref: Reactome:R-HSA-2466710 "Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs" +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016409 ! palmitoyltransferase activity + +[Term] +id: GO:0016417 +name: S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016418 +name: S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.38 +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016417 ! S-acyltransferase activity + +[Term] +id: GO:0016419 +name: S-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +xref: EC:2.3.1.39 +is_a: GO:0016417 ! S-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0016420 +name: malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016421 +name: CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0016422 +name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] +synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" RELATED [EC:2.1.1.62] +synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" RELATED [EC:2.1.1.62] +synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" RELATED [EC:2.1.1.62] +xref: EC:2.1.1.62 +xref: MetaCyc:2.1.1.62-RXN +xref: RHEA:22744 +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0016423 +name: tRNA (guanine) methyltransferase activity +namespace: molecular_function +alt_id: GO:0016424 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [GOC:go-curators] +synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016426 +name: tRNA (adenine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [GOC:go-curators] +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016427 +name: tRNA (cytosine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [GOC:go-curators] +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0016428 +name: tRNA (cytosine-5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] +synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" RELATED [EC:2.1.1.29] +synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" RELATED [EC:2.1.1.29] +synonym: "transfer RNA cytosine 5-methyltransferase activity" RELATED [EC:2.1.1.29] +xref: Reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)" +xref: Reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)" +xref: Reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)" +xref: Reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)" +xref: Reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)" +is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0016429 +name: tRNA (adenine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] +synonym: "1-methyladenine transfer RNA methyltransferase activity" RELATED [EC:2.1.1.36] +synonym: "adenine-1-methylase activity" RELATED [EC:2.1.1.36] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" RELATED [EC:2.1.1.36] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" RELATED [EC:2.1.1.36] +synonym: "transfer ribonucleate adenine 1-methyltransferase activity" RELATED [EC:2.1.1.36] +synonym: "transfer RNA (adenine-1) methyltransferase activity" RELATED [EC:2.1.1.36] +xref: Reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)" +xref: Reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58" +xref: Reactome:R-HSA-6787594 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9" +is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity + +[Term] +id: GO:0016430 +name: tRNA (adenine-N6-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" RELATED [EC:2.1.1.55] +synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" RELATED [EC:2.1.1.55] +xref: EC:2.1.1.55 +xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN +xref: RHEA:16785 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity + +[Term] +id: GO:0016432 +name: tRNA-uridine aminocarboxypropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] +synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" RELATED [EC:2.5.1.25] +xref: EC:2.5.1.25 +xref: MetaCyc:2.5.1.25-RXN +xref: RHEA:12300 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0016433 +name: rRNA (adenine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [GOC:go-curators] +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016434 +name: rRNA (cytosine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [GOC:go-curators] +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016435 +name: rRNA (guanine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [EC:2.1.1.-] +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016436 +name: rRNA (uridine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [GOC:go-curators] +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0016437 +name: tRNA cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] +synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] +synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [] +synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [] +synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [] +synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [] +synonym: "CTP:tRNA cytidylyltransferase activity" BROAD [] +synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [] +synonym: "ribonucleic cytidylyltransferase" BROAD [] +synonym: "transfer ribonucleate adenylyltransferase" BROAD [] +synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] +synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [] +synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [] +synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [] +synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [] +synonym: "transfer RNA adenylyltransferase" BROAD [] +synonym: "transfer-RNA nucleotidyltransferase" BROAD [] +synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [] +synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] +synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] +xref: EC:2.7.7.72 +xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN +is_a: GO:0070567 ! cytidylyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0016438 +name: tRNA-queuosine beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] +synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" RELATED [EC:2.4.1.110] +xref: EC:2.4.1.110 +xref: MetaCyc:2.4.1.110-RXN +xref: RHEA:12885 +is_a: GO:0000030 ! mannosyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0016441 +name: posttranscriptional gene silencing +namespace: biological_process +def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] +synonym: "cosuppression" RELATED [] +synonym: "post-transcriptional gene silencing" EXACT [GOC:vw] +synonym: "PTGS" EXACT [] +synonym: "quelling" EXACT [] +xref: Wikipedia:Post_transcriptional_gene_silencing +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0010629 ! negative regulation of gene expression + +[Term] +id: GO:0016442 +name: RISC complex +namespace: cellular_component +alt_id: GO:0035068 +def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] +synonym: "micro-ribonucleoprotein complex" RELATED [] +synonym: "miRNP complex" RELATED [] +synonym: "RNA-induced silencing complex" EXACT [] +xref: Wikipedia:RNA-induced_silencing_complex +is_a: GO:0031332 ! RNAi effector complex + +[Term] +id: GO:0016443 +name: bidentate ribonuclease III activity +namespace: molecular_function +def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] +synonym: "bidentate RNase III activity" EXACT [] +xref: EC:3.1.26.- +is_a: GO:0004525 ! ribonuclease III activity + +[Term] +id: GO:0016444 +name: somatic cell DNA recombination +namespace: biological_process +def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0016445 +name: somatic diversification of immunoglobulins +namespace: biological_process +def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] +synonym: "somatic diversification of antibodies" EXACT [] +is_a: GO:0002200 ! somatic diversification of immune receptors +relationship: part_of GO:0002377 ! immunoglobulin production + +[Term] +id: GO:0016446 +name: somatic hypermutation of immunoglobulin genes +namespace: biological_process +def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] +synonym: "somatic hypermutation of antibody genes" EXACT [] +is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0016447 +name: somatic recombination of immunoglobulin gene segments +namespace: biological_process +def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] +synonym: "somatic recombination of antibody gene segments" EXACT [] +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus +is_a: GO:0016445 ! somatic diversification of immunoglobulins + +[Term] +id: GO:0016453 +name: C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016407 ! acetyltransferase activity +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0016454 +name: C-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016408 ! C-acyltransferase activity +is_a: GO:0016409 ! palmitoyltransferase activity + +[Term] +id: GO:0016456 +name: X chromosome located dosage compensation complex, transcription activating +namespace: cellular_component +def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mr, GOC:mtg_sensu, PMID:20622855, Wikipedia:XY_sex-determination_system] +synonym: "dosage compensation complex" BROAD [] +is_a: GO:0046536 ! dosage compensation complex +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0000805 ! X chromosome + +[Term] +id: GO:0016457 +name: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl] +synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb] +is_a: GO:0042714 ! dosage compensation complex assembly +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome + +[Term] +id: GO:0016458 +name: obsolete gene silencing +namespace: biological_process +def: "OBSOLETE. Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] +comment: This term was obsoleted because its definition was too broad, and not distinct from 'GO:0045814 negative regulation of gene expression, epigenetic'. +xref: Wikipedia:Gene_silencing +is_obsolete: true +consider: GO:0010629 +consider: GO:0031507 + +[Term] +id: GO:0016459 +name: myosin complex +namespace: cellular_component +def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, Wikipedia:Myosin] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0016460 +name: myosin II complex +namespace: cellular_component +def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [Wikipedia:Myosin] +synonym: "conventional myosin" RELATED [] +is_a: GO:0016459 ! myosin complex + +[Term] +id: GO:0016461 +name: unconventional myosin complex +namespace: cellular_component +alt_id: GO:0005860 +def: "A portmanteau term for myosins other than myosin II." [GOC:ma] +comment: Note that this term is retained because it is widely used by biologists. +synonym: "non-muscle myosin" RELATED [] +is_a: GO:0016459 ! myosin complex + +[Term] +id: GO:0016462 +name: pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] +xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0016463 +name: P-type zinc transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)." [RHEA:20621] +synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [] +synonym: "P(1B)-type ATPase activity" NARROW [EC:7.2.2.12] +synonym: "P1B-type ATPase activity" RELATED [EC:7.2.2.12] +synonym: "zinc exporting ATPase activity" BROAD [] +synonym: "zinc transmembrane transporter activity, phosphorylative mechanism" RELATED [] +synonym: "zinc-exporting ATPase activity" RELATED [] +synonym: "zinc-translocating P-type ATPase activity" EXACT [EC:7.2.2.12] +synonym: "Zn(2+)-exporting ATPase activity" RELATED [EC:7.2.2.12] +synonym: "Zn2+-exporting ATPase activity" RELATED [EC:7.2.2.12] +xref: EC:7.2.2.12 +xref: MetaCyc:3.6.3.5-RXN +xref: RHEA:20621 +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0016464 +name: chloroplast protein-transporting ATPase activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:7.4.2.4] +synonym: "AAA chloroplast protein-transporting ATPase" EXACT [] +synonym: "ATPase-coupled chloroplast protein transporter activity" EXACT [] +xref: EC:7.4.2.4 +xref: MetaCyc:3.6.3.52-RXN +is_a: GO:0015450 ! protein-transporting ATPase activity + +[Term] +id: GO:0016465 +name: chaperonin ATPase complex +namespace: cellular_component +def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] +is_a: GO:0101031 ! chaperone complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0016466 +name: obsolete hydrogen-translocating A-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1] +comment: This term was made obsolete because it represents a gene product. +synonym: "hydrogen-translocating A-type ATPase activity" EXACT [] +synonym: "proton-translocating A-type ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0046961 + +[Term] +id: GO:0016467 +name: obsolete hydrogen-translocating F-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP synthase" BROAD [] +synonym: "F1-ATPase activity" EXACT [] +synonym: "hydrogen-translocating F-type ATPase activity" EXACT [] +synonym: "proton-translocating F-type ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046933 +consider: GO:0046961 + +[Term] +id: GO:0016468 +name: obsolete sodium-translocating F-type ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2] +comment: This term was made obsolete because it represents a gene product. +synonym: "ATP synthase" BROAD [] +synonym: "sodium-translocating F-type ATPase activity" EXACT [] +is_obsolete: true +consider: GO:0046932 +consider: GO:0046962 + +[Term] +id: GO:0016469 +name: proton-transporting two-sector ATPase complex +namespace: cellular_component +def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] +synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] +is_a: GO:0098796 ! membrane protein complex + +[Term] +id: GO:0016471 +name: vacuolar proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] +comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. +synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] +is_a: GO:0033176 ! proton-transporting V-type ATPase complex +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0016472 +name: sodium ion-transporting two-sector ATPase complex +namespace: cellular_component +def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] +subset: goslim_pir +synonym: "sodium-transporting two-sector ATPase complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016021 ! integral component of membrane + +[Term] +id: GO:0016473 +name: sodium ion-transporting F-type ATPase complex +namespace: cellular_component +def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] +synonym: "sodium-translocating F-type ATPase complex" EXACT [] +is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex + +[Term] +id: GO:0016474 +name: sodium ion-transporting V-type ATPase complex +namespace: cellular_component +def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] +synonym: "sodium-translocating V-type ATPase complex" EXACT [] +is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex + +[Term] +id: GO:0016475 +name: detection of nuclear:cytoplasmic ratio +namespace: biological_process +def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl] +synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT [] +synonym: "sensing of nuclear:cytoplasmic ratio" EXACT [] +is_a: GO:0009726 ! detection of endogenous stimulus +relationship: part_of GO:0016049 ! cell growth + +[Term] +id: GO:0016476 +name: regulation of embryonic cell shape +namespace: biological_process +def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] +synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb] +is_a: GO:0008360 ! regulation of cell shape +is_a: GO:0045995 ! regulation of embryonic development + +[Term] +id: GO:0016477 +name: cell migration +namespace: biological_process +def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration] +xref: Wikipedia:Cell_migration +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0016479 +name: negative regulation of transcription by RNA polymerase I +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW [] +synonym: "negative regulation of transcription from Pol I promoter" EXACT [] +synonym: "negative regulation of transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0006356 ! regulation of transcription by RNA polymerase I +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +relationship: negatively_regulates GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0016480 +name: negative regulation of transcription by RNA polymerase III +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW [] +synonym: "negative regulation of transcription from Pol III promoter" EXACT [] +synonym: "negative regulation of transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006359 ! regulation of transcription by RNA polymerase III +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +relationship: negatively_regulates GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0016482 +name: cytosolic transport +namespace: biological_process +def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0016483 +name: tryptophan hydroxylase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0016484 +name: obsolete proprotein convertase 2 activator activity +namespace: molecular_function +def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "proprotein convertase 2 activator activity" EXACT [] +is_obsolete: true +consider: GO:0016504 + +[Term] +id: GO:0016485 +name: protein processing +namespace: biological_process +alt_id: GO:0051605 +def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] +subset: goslim_chembl +synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] +synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] +synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] +synonym: "protein maturation by proteolysis" RELATED [GOC:mah] +is_a: GO:0006508 ! proteolysis +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0016486 +name: peptide hormone processing +namespace: biological_process +def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0140448 ! signaling receptor ligand precursor processing + +[Term] +id: GO:0016487 +name: farnesol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] +synonym: "farnesol metabolism" EXACT [] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0016093 ! polyprenol metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process + +[Term] +id: GO:0016488 +name: farnesol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] +synonym: "farnesol breakdown" EXACT [] +synonym: "farnesol catabolism" EXACT [] +synonym: "farnesol degradation" EXACT [] +is_a: GO:0016095 ! polyprenol catabolic process +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0016487 ! farnesol metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process + +[Term] +id: GO:0016490 +name: structural constituent of peritrophic membrane +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "structural constituent of peritrophic matrix" RELATED [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0016491 +name: oxidoreductase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_yeast +synonym: "oxidoreductase activity, acting on other substrates" NARROW [] +synonym: "redox activity" EXACT [] +xref: EC:1.-.-.- +xref: Reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" +xref: Reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated" +xref: Reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated" +xref: Reactome:R-HSA-3095889 "MMACHC reduces Cbl" +xref: Reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL" +xref: Reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL" +xref: Reactome:R-HSA-5662660 "Dopachrome is transformed to DHICA by DCT" +xref: Reactome:R-HSA-8878581 "TYRP1 oxidises DHICA to IQCA" +xref: Reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds" +xref: Reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" +xref: Reactome:R-HSA-9020260 "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5" +xref: Reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" +xref: Reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" +xref: Reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" +xref: Reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" +xref: Reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" +xref: Reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" +xref: Reactome:R-HSA-9693722 "Unknown sepiapterin synthase transforms PTHP to sepiapterin" +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016492 +name: G protein-coupled neurotensin receptor activity +namespace: molecular_function +def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649] +synonym: "G protein coupled neurotensin receptor activity" EXACT [] +synonym: "G-protein coupled neurotensin receptor activity" EXACT [] +synonym: "neurotensin receptor activity, G protein coupled" EXACT [] +synonym: "neurotensin receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0016493 +name: C-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823] +is_a: GO:0004950 ! chemokine receptor activity + +[Term] +id: GO:0016494 +name: C-X-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823] +is_a: GO:0004950 ! chemokine receptor activity + +[Term] +id: GO:0016495 +name: C-X3-C chemokine receptor activity +namespace: molecular_function +def: "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling] +is_a: GO:0004950 ! chemokine receptor activity + +[Term] +id: GO:0016496 +name: substance P receptor activity +namespace: molecular_function +def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016497 +name: substance K receptor activity +namespace: molecular_function +def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] +synonym: "neurokinin A receptor activity" EXACT [] +synonym: "neuromedin L receptor activity" EXACT [] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016498 +name: neuromedin K receptor activity +namespace: molecular_function +def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] +synonym: "neurokinin B receptor activity" EXACT [] +is_a: GO:0004995 ! tachykinin receptor activity + +[Term] +id: GO:0016499 +name: orexin receptor activity +namespace: molecular_function +def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0016500 +name: protein-hormone receptor activity +namespace: molecular_function +def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0016501 +name: prostacyclin receptor activity +namespace: molecular_function +alt_id: GO:0004959 +def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732] +synonym: "PGI receptor activity" RELATED [] +synonym: "PGI(2) receptor activity" EXACT [] +synonym: "prostaglandin I receptor activity" EXACT [] +is_a: GO:0004955 ! prostaglandin receptor activity + +[Term] +id: GO:0016502 +name: nucleotide receptor activity +namespace: molecular_function +def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0016503 +name: pheromone receptor activity +namespace: molecular_function +def: "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [GOC:hjd, ISBN:0198506732] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0016504 +name: peptidase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai] +synonym: "protease activator activity" NARROW [GOC:mah] +xref: Reactome:R-HSA-168865 "NA activation of TGF-beta" +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0061134 ! peptidase regulator activity + +[Term] +id: GO:0016505 +name: peptidase activator activity involved in apoptotic process +namespace: molecular_function +def: "Binds to and increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] +synonym: "apoptotic protease activator activity" NARROW [] +is_a: GO:0016504 ! peptidase activator activity + +[Term] +id: GO:0016506 +name: obsolete apoptosis activator activity +namespace: molecular_function +def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb] +comment: This term was made obsolete because it represents involvement in a biological process. +synonym: "apoptosis activator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0006915 + +[Term] +id: GO:0016507 +name: mitochondrial fatty acid beta-oxidation multienzyme complex +namespace: cellular_component +def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] +synonym: "fatty acid beta-oxidation multienzyme complex" BROAD [GOC:imk] +synonym: "trifunctional enzyme" RELATED [] +is_a: GO:0036125 ! fatty acid beta-oxidation multienzyme complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0016508 +name: long-chain-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [EC:4.2.1.74] +synonym: "long-chain enoyl coenzyme A hydratase activity" RELATED [EC:4.2.1.74] +synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.74] +xref: EC:4.2.1.74 +xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN +xref: Reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA" +xref: Reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA" +xref: Reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA" +xref: Reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA" +xref: Reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA" +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0016509 +name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [EC:1.1.1.211, GOC:pde] +comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. +synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" RELATED [EC:1.1.1.211] +synonym: "LCHAD" RELATED [EC:1.1.1.211] +synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.211] +synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.211] +xref: EC:1.1.1.211 +xref: MetaCyc:1.1.1.211-RXN +xref: Reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA" +is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity + +[Term] +id: GO:0016511 +name: obsolete endothelin-converting enzyme activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "endothelin-converting enzyme activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016512 +name: obsolete endothelin-converting enzyme 1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "ECE-1 activity" RELATED [] +synonym: "endothelin-converting enzyme 1 activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016513 +name: core-binding factor complex +namespace: cellular_component +def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254] +synonym: "AML1 complex" NARROW [] +synonym: "CBF complex" EXACT [] +synonym: "PEPB2 complex" NARROW [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0016514 +name: SWI/SNF complex +namespace: cellular_component +def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof." [GOC:bhm, PMID:12672490] +synonym: "SWI-SNF complex" EXACT [GOC:mah] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0016515 +name: interleukin-13 receptor activity +namespace: molecular_function +def: "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-13 receptor activity" EXACT [GOC:mah] +synonym: "IL-13R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0016516 +name: interleukin-4 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772] +synonym: "IL-4 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0016517 +name: interleukin-12 receptor activity +namespace: molecular_function +def: "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-12 receptor activity" EXACT [GOC:mah] +synonym: "IL-12R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0016518 +name: obsolete interleukin-14 receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "IL-14 receptor activity" EXACT [GOC:mah] +synonym: "IL-14R" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016519 +name: gastric inhibitory peptide receptor activity +namespace: molecular_function +def: "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312] +synonym: "GIP receptor activity" EXACT [PMID:19251046] +synonym: "glucose-dependent insulinotropic polypeptide receptor activity" EXACT [PMID:19251046] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0016520 +name: growth hormone-releasing hormone receptor activity +namespace: molecular_function +def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0016521 +name: pituitary adenylate cyclase activating polypeptide activity +namespace: molecular_function +def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477] +synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016524 +name: latrotoxin receptor activity +namespace: molecular_function +def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961] +synonym: "latrophilin" NARROW [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0016525 +name: negative regulation of angiogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] +synonym: "down regulation of angiogenesis" EXACT [] +synonym: "down-regulation of angiogenesis" EXACT [] +synonym: "downregulation of angiogenesis" EXACT [] +synonym: "inhibition of angiogenesis" NARROW [] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis +relationship: negatively_regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0016527 +name: obsolete brain-specific angiogenesis inhibitor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined. +synonym: "brain-specific angiogenesis inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0004930 + +[Term] +id: GO:0016528 +name: sarcoplasm +namespace: cellular_component +def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] +xref: Wikipedia:Sarcoplasm +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:0016529 +name: sarcoplasmic reticulum +namespace: cellular_component +alt_id: GO:0008221 +def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] +comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. +xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum +is_a: GO:0005783 ! endoplasmic reticulum +relationship: part_of GO:0016528 ! sarcoplasm + +[Term] +id: GO:0016530 +name: metallochaperone activity +namespace: molecular_function +def: "Binding to and delivering metal ions to a target protein." [PMID:11739376] +subset: goslim_pir +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0016531 +name: copper chaperone activity +namespace: molecular_function +def: "Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376] +is_a: GO:0016530 ! metallochaperone activity + +[Term] +id: GO:0016532 +name: superoxide dismutase copper chaperone activity +namespace: molecular_function +def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278] +comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'. +is_a: GO:0016531 ! copper chaperone activity + +[Term] +id: GO:0016533 +name: protein kinase 5 complex +namespace: cellular_component +def: "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152] +synonym: "cyclin-dependent protein kinase 5 holoenzyme complex" RELATED [] +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0016536 +name: obsolete cyclin-dependent protein kinase 5 activator regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] +comment: This term was made obsolete because it refers to a specific gene product. +synonym: "cyclin-dependent protein kinase 5 activator regulator activity" EXACT [] +synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] +is_obsolete: true + +[Term] +id: GO:0016538 +name: cyclin-dependent protein serine/threonine kinase regulator activity +namespace: molecular_function +alt_id: GO:0003751 +alt_id: GO:0003752 +alt_id: GO:0003753 +def: "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] +synonym: "cyclin" BROAD [] +synonym: "cyclin-dependent protein kinase regulator activity" BROAD [] +synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] +synonym: "G1/S-specific cyclin" NARROW [] +synonym: "G2/M-specific cyclin" NARROW [] +xref: Reactome:R-HSA-3215385 "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77" +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0016539 +name: intein-mediated protein splicing +namespace: biological_process +def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] +synonym: "intein" RELATED [] +is_a: GO:0030908 ! protein splicing + +[Term] +id: GO:0016540 +name: protein autoprocessing +namespace: biological_process +def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] +subset: goslim_chembl +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0016541 +name: obsolete intein +namespace: molecular_function +def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123] +comment: This term was made obsolete because it refers to a protein sequence feature. +synonym: "intein" EXACT [] +is_obsolete: true +consider: GO:0004519 +consider: GO:0016539 + +[Term] +id: GO:0016543 +name: male courtship behavior, orientation prior to leg tapping and wing vibration +namespace: biological_process +def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827] +synonym: "male courtship behavior, orientation" RELATED [] +synonym: "male courtship behaviour, orientation" RELATED [] +synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016544 +name: male courtship behavior, tapping to detect pheromone +namespace: biological_process +def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior, tapping" RELATED [] +synonym: "male courtship behaviour, tapping" EXACT [] +synonym: "male courtship behaviour, tapping to detect pheromone" RELATED [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016545 +name: male courtship behavior, veined wing vibration +namespace: biological_process +def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior, wing vibration" RELATED [] +synonym: "male courtship behaviour, veined wing vibration" EXACT [] +synonym: "male courtship behaviour, wing vibration" RELATED [] +is_a: GO:0048065 ! male courtship behavior, veined wing extension + +[Term] +id: GO:0016546 +name: male courtship behavior, proboscis-mediated licking +namespace: biological_process +def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior, licking" RELATED [] +synonym: "male courtship behaviour, licking" RELATED [] +synonym: "male courtship behaviour, proboscis-mediated licking" EXACT [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0016550 +name: obsolete insertion or deletion editing +namespace: biological_process +def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837] +comment: This term was made obsolete because it represents two separate processes (insertion and deletion). +synonym: "insertion or deletion editing" EXACT [] +synonym: "insertion/deletion editing" EXACT [] +is_obsolete: true +consider: GO:0070705 +consider: GO:0070706 + +[Term] +id: GO:0016551 +name: obsolete posttranscriptional insertion or deletion editing +namespace: biological_process +def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837] +comment: This term was made obsolete because it represents two separate processes (insertion and deletion). +synonym: "posttranscriptional insertion or deletion editing" EXACT [] +synonym: "posttranscriptional insertion/deletion editing" EXACT [] +is_obsolete: true +consider: GO:0070705 +consider: GO:0070706 + +[Term] +id: GO:0016552 +name: obsolete cotranscriptional insertion or deletion editing +namespace: biological_process +def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837] +comment: This term was made obsolete because it represents two separate processes (insertion and deletion). +synonym: "cotranscriptional insertion or deletion editing" EXACT [] +synonym: "cotranscriptional insertion/deletion editing" EXACT [] +is_obsolete: true +consider: GO:0070705 +consider: GO:0070706 + +[Term] +id: GO:0016553 +name: base conversion or substitution editing +namespace: biological_process +def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837] +synonym: "base conversion/substitution editing" EXACT [] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0016554 +name: cytidine to uridine editing +namespace: biological_process +def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837] +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0016555 +name: uridine to cytidine editing +namespace: biological_process +def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837] +is_a: GO:0016553 ! base conversion or substitution editing + +[Term] +id: GO:0016556 +name: mRNA modification +namespace: biological_process +alt_id: GO:0006381 +def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] +comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. +synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0009451 ! RNA modification +is_a: GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:0016557 +name: peroxisome membrane biogenesis +namespace: biological_process +def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah] +is_a: GO:0044091 ! membrane biogenesis +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0016558 +name: protein import into peroxisome matrix +namespace: biological_process +def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772] +synonym: "peroxisome matrix protein import" EXACT [] +synonym: "protein transport to peroxisome matrix" EXACT [] +is_a: GO:0006625 ! protein targeting to peroxisome +is_a: GO:0015919 ! peroxisomal membrane transport +is_a: GO:0044743 ! protein transmembrane import into intracellular organelle +is_a: GO:0065002 ! intracellular protein transmembrane transport + +[Term] +id: GO:0016559 +name: peroxisome fission +namespace: biological_process +def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] +synonym: "peroxisome division" EXACT [] +synonym: "peroxisome proliferation" EXACT [] +is_a: GO:0048285 ! organelle fission +relationship: part_of GO:0007031 ! peroxisome organization + +[Term] +id: GO:0016560 +name: protein import into peroxisome matrix, docking +namespace: biological_process +def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507] +synonym: "peroxisome matrix protein import, docking" EXACT [] +synonym: "peroxisome receptor docking" RELATED [] +synonym: "protein docking during peroxisome matrix protein import" EXACT [] +synonym: "protein docking during protein import into peroxisome matrix" EXACT [] +synonym: "protein docking during protein transport into peroxisome matrix" EXACT [] +synonym: "protein transport into peroxisome matrix, docking" EXACT [] +is_a: GO:0008104 ! protein localization +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016561 +name: protein import into peroxisome matrix, translocation +namespace: biological_process +def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502] +synonym: "peroxisome matrix protein import, translocation" EXACT [] +synonym: "peroxisome receptor translocation" RELATED [] +synonym: "protein translocation during peroxisome matrix protein import" EXACT [] +synonym: "protein translocation during protein import into peroxisome matrix" EXACT [] +synonym: "protein translocation during protein transport into peroxisome matrix" EXACT [] +synonym: "protein transport into peroxisome matrix, translocation" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016562 +name: protein import into peroxisome matrix, receptor recycling +namespace: biological_process +def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502] +synonym: "peroxisome matrix protein import, receptor recycling" EXACT [] +synonym: "peroxisome receptor recycling" RELATED [] +synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT [] +synonym: "PTS receptor recycling" RELATED [] +synonym: "receptor recycling during peroxisome matrix protein import" EXACT [] +synonym: "receptor recycling during protein import into peroxisome matrix" EXACT [] +synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT [] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0016563 +name: obsolete transcription activator activity +namespace: molecular_function +alt_id: GO:0003710 +def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "transcription activating factor" NARROW [] +synonym: "transcription activator activity" EXACT [] +synonym: "transcriptional activator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0001228 + +[Term] +id: GO:0016564 +name: obsolete transcription repressor activity +namespace: molecular_function +def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "negative transcriptional regulator activity" EXACT [] +synonym: "transcription repressor activity" EXACT [] +synonym: "transcriptional repressor activity" EXACT [] +is_obsolete: true +consider: GO:0001227 + +[Term] +id: GO:0016565 +name: obsolete general transcriptional repressor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] +comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "general transcriptional repressor activity" EXACT [] +is_obsolete: true +consider: GO:0001217 +consider: GO:0001227 +consider: GO:0045892 + +[Term] +id: GO:0016566 +name: obsolete specific transcriptional repressor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] +comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "specific transcriptional repressor activity" EXACT [] +is_obsolete: true +consider: GO:0001217 +consider: GO:0001227 +consider: GO:0045892 + +[Term] +id: GO:0016567 +name: protein ubiquitination +namespace: biological_process +def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] +synonym: "protein ubiquitinylation" EXACT [] +synonym: "protein ubiquitylation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0016569 +name: obsolete covalent chromatin modification +namespace: biological_process +def: "OBSOLETE. The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "chromatin modification" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016570 +name: histone modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] +subset: goslim_yeast +xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0016571 +name: histone methylation +namespace: biological_process +def: "The modification of histones by addition of methyl groups." [GOC:ai] +xref: Wikipedia:Histone_methylation +is_a: GO:0006479 ! protein methylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016572 +name: histone phosphorylation +namespace: biological_process +def: "The modification of histones by addition of phosphate groups." [GOC:ai] +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016573 +name: histone acetylation +namespace: biological_process +def: "The modification of a histone by the addition of an acetyl group." [GOC:ai] +is_a: GO:0016570 ! histone modification +is_a: GO:0018393 ! internal peptidyl-lysine acetylation + +[Term] +id: GO:0016574 +name: histone ubiquitination +namespace: biological_process +def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] +synonym: "histone ubiquitinylation" EXACT [] +synonym: "histone ubiquitylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016575 +name: histone deacetylation +namespace: biological_process +def: "The modification of histones by removal of acetyl groups." [GOC:ai] +is_a: GO:0006476 ! protein deacetylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016576 +name: histone dephosphorylation +namespace: biological_process +def: "The modification of histones by removal of phosphate groups." [GOC:ai] +is_a: GO:0006470 ! protein dephosphorylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016577 +name: histone demethylation +namespace: biological_process +def: "The modification of histones by removal of methyl groups." [GOC:ai] +is_a: GO:0006482 ! protein demethylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0016578 +name: histone deubiquitination +namespace: biological_process +def: "The modification of histones by removal of ubiquitin groups." [GOC:ai] +synonym: "histone deubiquitinylation" EXACT [] +synonym: "histone deubiquitylation" EXACT [] +is_a: GO:0016570 ! histone modification +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0016579 +name: protein deubiquitination +namespace: biological_process +alt_id: GO:0006514 +def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai] +synonym: "deubiquitination" EXACT [] +synonym: "protein deubiquitinylation" EXACT [] +synonym: "protein deubiquitylation" EXACT [] +is_a: GO:0070646 ! protein modification by small protein removal + +[Term] +id: GO:0016580 +name: Sin3 complex +namespace: cellular_component +def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] +is_a: GO:0070822 ! Sin3-type complex + +[Term] +id: GO:0016581 +name: NuRD complex +namespace: cellular_component +def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] +synonym: "Mi-2 complex" EXACT [] +synonym: "NRD complex" EXACT [] +synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex +is_a: GO:0005667 ! transcription regulator complex +is_a: GO:0090545 ! CHD-type complex + +[Term] +id: GO:0016582 +name: obsolete non-covalent chromatin modification +namespace: biological_process +def: "OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl, GOC:vw] +comment: This term was made obsolete because it was added in error; its usefulness is unclear. +is_obsolete: true + +[Term] +id: GO:0016583 +name: obsolete nucleosome modeling +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it has been replaced by more specific terms. +synonym: "nucleosome modeling" EXACT [] +is_obsolete: true +consider: GO:0006334 + +[Term] +id: GO:0016584 +name: nucleosome positioning +namespace: biological_process +def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] +synonym: "nucleosome spacing" EXACT [] +is_a: GO:0031497 ! chromatin assembly +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0016585 +name: obsolete chromatin remodeling complex +namespace: cellular_component +alt_id: GO:0005679 +def: "OBSOLETE. Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] +comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. +synonym: "chromatin remodeling complex" EXACT [] +synonym: "chromatin remodelling complex" EXACT [] +synonym: "nucleosome remodeling complex" EXACT [] +is_obsolete: true +consider: GO:0006338 + +[Term] +id: GO:0016586 +name: RSC-type complex +namespace: cellular_component +alt_id: GO:0070604 +def: "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231] +synonym: "PBAF complex" EXACT [] +synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565] +synonym: "SWI/SNF complex B" EXACT [CORUM:565] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0016587 +name: Isw1 complex +namespace: cellular_component +def: "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0016589 +name: NURF complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179] +synonym: "nucleosome remodeling factor complex" EXACT [] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0016590 +name: ACF complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179] +synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0016591 +name: RNA polymerase II, holoenzyme +namespace: cellular_component +def: "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] +subset: goslim_pir +synonym: "DNA-directed RNA polymerase II, holoenzyme" EXACT [] +is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0016592 +name: mediator complex +namespace: cellular_component +alt_id: GO:0000119 +def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] +synonym: "CDK8-containing TRAP/mediator complex" RELATED [] +synonym: "L mediator complex" EXACT [] +synonym: "Srb-mediator complex" EXACT [GOC:mah] +synonym: "TRAP complex" NARROW [] +xref: Wikipedia:Mediator_(coactivator) +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0016593 +name: Cdc73/Paf1 complex +namespace: cellular_component +def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] +synonym: "Paf1 complex" EXACT [GOC:cjk] +synonym: "Paf1p complex" EXACT [GOC:cjk] +is_a: GO:0008023 ! transcription elongation factor complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0016594 +name: glycine binding +namespace: molecular_function +def: "Binding to glycine, aminoethanoic acid." [GOC:ai] +synonym: "aminoacetic acid binding" EXACT [] +synonym: "aminoethanoic acid binding" EXACT [] +synonym: "Gly binding" EXACT [] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0016595 +name: glutamate binding +namespace: molecular_function +def: "Binding to glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] +synonym: "glutamic acid binding" EXACT [] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0016596 +name: thienylcyclohexylpiperidine binding +namespace: molecular_function +def: "Binding to thienylcyclohexylpiperidine." [GOC:jl] +synonym: "TCP binding" BROAD [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0016597 +name: amino acid binding +namespace: molecular_function +def: "Binding to an amino acid, organic acids containing one or more amino substituents." [GOC:ai] +subset: goslim_metagenomics +subset: goslim_pir +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0016598 +name: protein arginylation +namespace: biological_process +alt_id: GO:0019130 +def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865] +synonym: "protein amino acid arginylation" EXACT [] +is_a: GO:0006464 ! cellular protein modification process +relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0016600 +name: flotillin complex +namespace: cellular_component +def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] +comment: See also the cellular component term 'caveola ; GO:0005901'. +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005901 ! caveola + +[Term] +id: GO:0016601 +name: Rac protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] +synonym: "Rac mediated signal transduction" EXACT [] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0016602 +name: CCAAT-binding factor complex +namespace: cellular_component +def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] +synonym: "CBF complex" RELATED [GOC:bhm] +synonym: "NF-Y transcription factor complex" RELATED [GOC:bhm] +synonym: "nuclear transcription factor Y complex" RELATED [GOC:bhm] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0016603 +name: glutaminyl-peptide cyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] +synonym: "glutaminyl cyclase activity" RELATED [EC:2.3.2.5] +synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" RELATED [EC:2.3.2.5] +synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] +synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" RELATED [EC:2.3.2.5] +xref: EC:2.3.2.5 +xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN +xref: RHEA:23652 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0016604 +name: nuclear body +namespace: cellular_component +def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] +xref: NIF_Subcellular:sao505137457 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0016605 +name: PML body +namespace: cellular_component +def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] +synonym: "ND10" EXACT [] +synonym: "nuclear dot" RELATED [] +synonym: "PML NB" EXACT [] +synonym: "PML nuclear body" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016606 +name: LYSP100-associated nuclear domain +namespace: cellular_component +def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863] +synonym: "LANDs" EXACT [PMID:8695863] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016607 +name: nuclear speck +namespace: cellular_component +def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] +synonym: "nuclear speckle" EXACT [] +synonym: "nuclear speckles" EXACT [] +synonym: "speckle domain" NARROW [] +synonym: "speckle focus" RELATED [] +synonym: "splicing speckle" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0016608 +name: growth hormone-releasing hormone activity +namespace: molecular_function +def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732] +synonym: "GHRF activity" EXACT [ISBN:0198506732] +synonym: "GHRH activity" EXACT [ISBN:0198506732] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016610 +name: nitrogenase complex +namespace: cellular_component +def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0016611 +name: iron-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] +comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016612 +name: molybdenum-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] +synonym: "molybdenum-iron nitrogenase activity" RELATED [] +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016613 +name: vanadium-iron nitrogenase complex +namespace: cellular_component +def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] +synonym: "vanadium-iron nitrogenase activity" RELATED [] +is_a: GO:0016610 ! nitrogenase complex + +[Term] +id: GO:0016614 +name: oxidoreductase activity, acting on CH-OH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] +xref: EC:1.1.-.- +xref: Reactome:R-HSA-1500781 "Fgd1 reactivates F420" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016615 +name: malate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016616 +name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] +synonym: "glycolate reductase" RELATED [EC:1.1.1.26] +synonym: "glyoxylic acid reductase" RELATED [] +synonym: "NADH-dependent glyoxylate reductase" RELATED [] +xref: EC:1.1.1.- +xref: Reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL" +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016617 +name: 4-oxoproline reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] +synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.104] +synonym: "hydroxy-L-proline oxidase activity" EXACT [] +synonym: "hydroxyproline oxidase activity" RELATED [EC:1.1.1.104] +xref: EC:1.1.1.104 +xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN +xref: RHEA:13601 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016618 +name: hydroxypyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] +synonym: "beta-hydroxypyruvate reductase activity" RELATED [EC:1.1.1.81] +synonym: "D-glycerate dehydrogenase activity" RELATED [EC:1.1.1.81] +synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.81] +synonym: "NADH:hydroxypyruvate reductase activity" RELATED [EC:1.1.1.81] +xref: EC:1.1.1.81 +xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN +xref: MetaCyc:RXN0-300 +xref: RHEA:18657 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016620 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.2.1.- +xref: Reactome:R-HSA-1222583 "MscR reduces nitrosomycothiol to ammonia" +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016621 +name: cinnamoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] +synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" RELATED [EC:1.2.1.44] +synonym: "cinnamoyl CoA reductase activity" EXACT [] +synonym: "cinnamoyl-CoA:NADPH reductase activity" RELATED [EC:1.2.1.44] +synonym: "cinnamoyl-coenzyme A reductase activity" RELATED [EC:1.2.1.44] +synonym: "feruloyl coenzyme A reductase activity" RELATED [EC:1.2.1.44] +synonym: "feruloyl-CoA reductase activity" RELATED [EC:1.2.1.44] +synonym: "ferulyl-CoA reductase activity" RELATED [EC:1.2.1.44] +synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" RELATED [EC:1.2.1.44] +xref: EC:1.2.1.44 +xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN +xref: RHEA:10620 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016622 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +xref: EC:1.2.2.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016623 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +xref: EC:1.2.3.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016624 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.2.4.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016625 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.2.7.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0016626 +name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016903 + +[Term] +id: GO:0016627 +name: oxidoreductase activity, acting on the CH-CH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] +xref: EC:1.3.-.- +xref: Reactome:R-HSA-2995334 "COX15 transforms heme O to heme A" +xref: Reactome:R-HSA-9661710 "An unknown oxidase oxidises D-UBGN to UBN" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016628 +name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.3.1.- +xref: Reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL" +xref: Reactome:R-HSA-4755572 "Defective SRD5A3 does not reduce pPNOL to DCHOL" +xref: Reactome:R-HSA-9661726 "An unknown reductase reduces D-UBGN to STBN" +xref: Reactome:R-HSA-9661745 "An unknown BILR reduces BIL to D-UBGN" +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016629 +name: 12-oxophytodienoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21888] +synonym: "12-oxo-phytodienoate reductase activity" EXACT [] +synonym: "12-oxo-phytodienoic acid reductase activity" RELATED [EC:1.3.1.42] +synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" RELATED [EC:1.3.1.42] +xref: EC:1.3.1.42 +xref: KEGG_REACTION:R03401 +xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN +xref: RHEA:21888 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016630 +name: protochlorophyllide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] +synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" RELATED [EC:1.3.1.33] +synonym: "NADPH-protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33] +synonym: "NADPH-protochlorophyllide reductase activity" RELATED [EC:1.3.1.33] +synonym: "NADPH2-protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33] +synonym: "protochlorophyllide oxidoreductase activity" RELATED [EC:1.3.1.33] +synonym: "protochlorophyllide photooxidoreductase activity" RELATED [EC:1.3.1.33] +xref: EC:1.3.1.33 +xref: MetaCyc:RXN1F-10 +xref: RHEA:11132 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016631 +name: enoyl-[acyl-carrier-protein] reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] +synonym: "acyl-ACP dehydrogenase activity" RELATED [EC:1.3.1.9] +synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] +synonym: "enoyl-ACP reductase activity" EXACT [] +synonym: "enoyl-acyl carrier protein reductase" EXACT [] +xref: EC:1.3.1.9 +xref: MetaCyc:1.3.1.10-RXN +xref: MetaCyc:1.3.1.39-RXN +xref: MetaCyc:RXN1G-2527 +xref: MetaCyc:RXN1G-2544 +xref: MetaCyc:RXN1G-3232 +xref: MetaCyc:RXN1G-3256 +xref: MetaCyc:RXN1G-3613 +xref: MetaCyc:RXN1G-3641 +xref: MetaCyc:RXN1G-3667 +xref: MetaCyc:RXN1G-3993 +xref: MetaCyc:RXN1G-4140 +xref: MetaCyc:RXN1G-45 +xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016632 +name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +xref: EC:1.3.2.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016633 +name: galactonolactone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] +synonym: "GLDase activity" RELATED [EC:1.3.2.3] +synonym: "GLDHase activity" RELATED [EC:1.3.2.3] +synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] +synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.3.2.3] +synonym: "L-galactono-gamma-lactone dehydrogenase activity" RELATED [EC:1.3.2.3] +synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.3.2.3] +synonym: "L-galactonolactone dehydrogenase activity" RELATED [EC:1.3.2.3] +xref: EC:1.3.2.3 +xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN +xref: RHEA:32367 +is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor + +[Term] +id: GO:0016634 +name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +xref: EC:1.3.3.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016635 +name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] +xref: EC:1.3.5.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016636 +name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.3.7.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0016637 +name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016627 + +[Term] +id: GO:0016638 +name: oxidoreductase activity, acting on the CH-NH2 group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] +xref: EC:1.4.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016639 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +xref: EC:1.4.1.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016640 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] +xref: EC:1.4.2.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016641 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +xref: EC:1.4.3.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016642 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.4.4.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016643 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.4.7.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0016644 +name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016638 + +[Term] +id: GO:0016645 +name: oxidoreductase activity, acting on the CH-NH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] +xref: EC:1.5.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016646 +name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.5.1.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016647 +name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +xref: EC:1.5.3.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016648 +name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] +synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.5.4.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016649 +name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] +xref: EC:1.5.5.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0016650 +name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016645 + +[Term] +id: GO:0016651 +name: oxidoreductase activity, acting on NAD(P)H +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "NAD(P)H dehydrogenase" NARROW [] +synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED [] +synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] +xref: EC:1.6.-.- +xref: Reactome:R-HSA-109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" +xref: Reactome:R-HSA-8956458 "RNLS:FAD oxidises dh-beta-NAD to NAD+" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016652 +name: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +synonym: "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor" RELATED [] +xref: EC:1.6.1.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0016653 +name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] +synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] +synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED [] +xref: EC:1.6.2.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0016655 +name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] +synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED [] +xref: EC:1.6.5.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0016656 +name: monodehydroascorbate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] +synonym: "AFR" RELATED [EC:1.6.5.4] +synonym: "AFR-reductase activity" RELATED [EC:1.6.5.4] +synonym: "ascorbate free radical reductase activity" RELATED [EC:1.6.5.4] +synonym: "ascorbate free-radical reductase activity" RELATED [EC:1.6.5.4] +synonym: "ascorbic free radical reductase activity" RELATED [EC:1.6.5.4] +synonym: "MDAsA reductase (NADPH)" RELATED [EC:1.6.5.4] +synonym: "MDHA" RELATED [EC:1.6.5.4] +synonym: "monodehydroascorbate reductase activity" EXACT [] +synonym: "NADH-semidehydroascorbate oxidoreductase activity" RELATED [EC:1.6.5.4] +synonym: "NADH:AFR oxidoreductase activity" RELATED [EC:1.6.5.4] +synonym: "NADH:ascorbate radical oxidoreductase activity" RELATED [EC:1.6.5.4] +synonym: "NADH:monodehydroascorbate oxidoreductase activity" RELATED [EC:1.6.5.4] +synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" RELATED [EC:1.6.5.4] +synonym: "SDA reductase activity" RELATED [EC:1.6.5.4] +synonym: "semidehydroascorbate reductase activity" RELATED [EC:1.6.5.4] +xref: EC:1.6.5.4 +xref: MetaCyc:1.6.5.4-RXN +xref: RHEA:14581 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0016657 +name: oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] +synonym: "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" RELATED [] +xref: EC:1.6.6.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0016658 +name: obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it. +synonym: "oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor" EXACT [] +is_obsolete: true +consider: GO:0008752 +consider: GO:0042602 + +[Term] +id: GO:0016659 +name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" EXACT [] +is_obsolete: true +consider: GO:0016651 + +[Term] +id: GO:0016661 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] +xref: EC:1.7.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016662 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +xref: EC:1.7.2.- +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016663 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +xref: EC:1.7.3.- +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016664 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.7.7.- +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0016665 +name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016661 + +[Term] +id: GO:0016667 +name: oxidoreductase activity, acting on a sulfur group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] +synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] +xref: EC:1.8.-.- +xref: Reactome:R-HSA-2213240 "Reduction of disulphide bonds in MHC II antigens" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016668 +name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor +namespace: molecular_function +alt_id: GO:0016654 +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED [] +synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT [] +synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] +synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] +xref: EC:1.8.1.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016669 +name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] +xref: EC:1.8.2.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016670 +name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] +xref: EC:1.8.3.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016671 +name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] +synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.8.4.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016672 +name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] +synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] +xref: EC:1.8.5.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016673 +name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.8.7.- +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0016674 +name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" EXACT [] +synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016667 + +[Term] +id: GO:0016675 +name: oxidoreductase activity, acting on a heme group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] +synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] +xref: EC:1.9.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016676 +name: obsolete oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +comment: This term was obsoleted because Enzyme Commission (EC) has rehoused all its descendant classes, and this is now a grouping term with not children. +synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] +xref: EC:1.9.3.- +is_obsolete: true + +[Term] +id: GO:0016677 +name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] +synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] +xref: EC:1.9.6.- +is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors + +[Term] +id: GO:0016678 +name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT [] +synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016675 + +[Term] +id: GO:0016679 +name: oxidoreductase activity, acting on diphenols and related substances as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] +xref: EC:1.10.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016680 +name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.10.1.- +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0016681 +name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] +comment: This term was obsoleted because the EC it represented was obsoleted. +xref: EC:1.10.2.- +is_obsolete: true + +[Term] +id: GO:0016682 +name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] +synonym: "laccase activity" RELATED [GOC:jh] +xref: EC:1.10.3.- +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0016683 +name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016679 + +[Term] +id: GO:0016684 +name: oxidoreductase activity, acting on peroxide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] +xref: EC:1.11.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016688 +name: L-ascorbate peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11] +synonym: "ascorbate peroxidase activity" RELATED [EC:1.11.1.11] +synonym: "ascorbic acid peroxidase activity" RELATED [EC:1.11.1.11] +synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.11] +synonym: "L-ascorbic acid peroxidase activity" RELATED [EC:1.11.1.11] +synonym: "L-ascorbic acid-specific peroxidase activity" RELATED [EC:1.11.1.11] +xref: EC:1.11.1.11 +xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN +xref: RHEA:22996 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016689 +name: manganese peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] +synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.13] +synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" RELATED [EC:1.11.1.13] +synonym: "Mn-dependent peroxidase activity" RELATED [EC:1.11.1.13] +synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] +xref: EC:1.11.1.13 +xref: MetaCyc:MANGANESE-PEROXIDASE-RXN +xref: RHEA:22776 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016690 +name: diarylpropane peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14] +synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.14] +synonym: "diarylpropane oxygenase activity" RELATED [EC:1.11.1.14] +synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" RELATED [EC:1.11.1.14] +synonym: "lignin peroxidase activity" RELATED [EC:1.11.1.14] +synonym: "ligninase activity" RELATED [EC:1.11.1.14] +synonym: "ligninase I activity" NARROW [EC:1.11.1.14] +synonym: "LiP activity" NARROW [EC:1.11.1.14] +xref: EC:1.11.1.14 +xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN +xref: RHEA:30271 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016691 +name: chloride peroxidase activity +namespace: molecular_function +alt_id: GO:0016955 +alt_id: GO:0016956 +alt_id: GO:0016957 +alt_id: GO:0016958 +def: "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10] +synonym: "chloride:hydrogen-peroxide oxidoreductase" RELATED [EC:1.11.1.10] +synonym: "chloroperoxidase activity" RELATED [EC:1.11.1.10] +synonym: "cofactor-free chloroperoxidase activity" NARROW [] +synonym: "flavin-haem chloroperoxidase activity" NARROW [] +synonym: "flavin-heme chloroperoxidase activity" NARROW [] +synonym: "haem chloroperoxidase activity" NARROW [] +synonym: "heme chloroperoxidase activity" NARROW [] +synonym: "vanadium chloroperoxidase activity" NARROW [] +xref: EC:1.11.1.10 +xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016692 +name: NADH peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+)." [EC:1.11.1.1, RHEA:18509] +synonym: "diphosphopyridine nucleotide peroxidase activity" RELATED [EC:1.11.1.1] +synonym: "DPNH peroxidase activity" RELATED [EC:1.11.1.1] +synonym: "NAD peroxidase activity" RELATED [EC:1.11.1.1] +synonym: "NADH-peroxidase activity" RELATED [EC:1.11.1.1] +synonym: "NADH:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.1] +synonym: "nicotinamide adenine dinucleotide peroxidase activity" RELATED [EC:1.11.1.1] +xref: EC:1.11.1.1 +xref: KEGG_REACTION:R00090 +xref: MetaCyc:NADH-PEROXIDASE-RXN +xref: RHEA:18509 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0016694 +name: obsolete bacterial catalase-peroxidase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it represents a bifunctional gene product. +synonym: "bacterial catalase-peroxidase activity" EXACT [] +is_obsolete: true +consider: GO:0004096 +consider: GO:0004601 + +[Term] +id: GO:0016695 +name: oxidoreductase activity, acting on hydrogen as donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] +synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] +xref: EC:1.12.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016696 +name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.12.1.- +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016697 +name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor +namespace: molecular_function +alt_id: GO:0016698 +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] +xref: EC:1.12.2.- +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016699 +name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor +namespace: molecular_function +alt_id: GO:0016736 +alt_id: GO:0019110 +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] +synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.12.7.- +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0016700 +name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016695 + +[Term] +id: GO:0016701 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] +synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] +synonym: "oxygenase" BROAD [] +xref: EC:1.13.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016702 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] +xref: EC:1.13.11.- +xref: Reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4" +xref: Reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4" +xref: Reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4" +xref: Reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION" +xref: Reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE" +xref: Reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA" +xref: Reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3" +xref: Reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA" +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0016703 +name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] +xref: EC:1.13.12.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0016704 +name: obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" EXACT [] +is_obsolete: true +consider: GO:0016701 + +[Term] +id: GO:0016705 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] +xref: EC:1.14.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016706 +name: 2-oxoglutarate-dependent dioxygenase activity +namespace: molecular_function +alt_id: GO:0010302 +def: "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] +synonym: "2-oxoglutarate dioxygenase activity" EXACT [] +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" EXACT [] +xref: EC:1.14.11.- +xref: Reactome:R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)" +xref: Reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)" +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0016707 +name: gibberellin 3-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad] +synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] +synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] +synonym: "gibberellin 3-beta-hydroxylase activity" RELATED [EC:1.14.11.15] +synonym: "gibberellin 3beta-dioxygenase activity" RELATED [EC:1.14.11.15] +synonym: "gibberellin 3beta-hydroxylase activity" RELATED [EC:1.14.11.15] +xref: EC:1.14.11.15 +xref: MetaCyc:RXN1F-170 +xref: RHEA:10104 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0016708 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [GOC:mah] +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor" RELATED [] +xref: EC:1.14.12.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0016709 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen" RELATED [] +xref: EC:1.14.13.- +xref: Reactome:R-HSA-2162187 "DHB is hydroxylated to DHDB by COQ6" +xref: Reactome:R-HSA-2162194 "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2" +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016710 +name: trans-cinnamate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.14.91] +synonym: "CA4H activity" NARROW [EC:1.14.14.91] +synonym: "cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamate 4-monooxygenase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamate hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamic 4-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamic acid 4-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamic acid 4-monooxygenase activity" RELATED [EC:1.14.14.91] +synonym: "cinnamic acid p-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "hydroxylase, cinnamate 4-" RELATED [EC:1.14.14.91] +synonym: "oxygenase, cinnamate 4-mono-" RELATED [EC:1.14.14.91] +synonym: "t-cinnamic acid hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "trans-cinnamate 4-hydroxylase activity" RELATED [EC:1.14.14.91] +synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.14.91] +synonym: "trans-cinnamic acid 4-hydroxylase activity" RELATED [EC:1.14.14.91] +xref: EC:1.14.14.91 +xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN +xref: RHEA:10608 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0016711 +name: flavonoid 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.14.82] +synonym: "flavonoid 3'-hydroxylase activity" RELATED [EC:1.14.14.82] +synonym: "flavonoid 3-hydroxylase" RELATED [] +synonym: "flavonoid 3-monooxygenase" RELATED [] +synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.82] +synonym: "NADPH:flavonoid-3'-hydroxylase activity" RELATED [EC:1.14.14.82] +xref: EC:1.14.14.82 +xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN +xref: RHEA:16337 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0016712 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +alt_id: GO:0008402 +alt_id: GO:0050381 +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1] +synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1] +synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] +synonym: "cytochrome P450 CYP19" NARROW [] +synonym: "flavoprotein monooxygenase activity" RELATED [EC:1.14.14.1] +synonym: "flavoprotein-linked monooxygenase activity" RELATED [EC:1.14.14.1] +synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] +synonym: "microsomal P-450" RELATED [EC:1.14.14.1] +synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] +synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" RELATED [EC:1.14.14.1] +synonym: "unspecific monooxygenase activity" RELATED [] +synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] +xref: EC:1.14.14.- +xref: Reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine" +xref: UM-BBD_enzymeID:e0551 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016713 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] +xref: EC:1.14.15.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016714 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +xref: EC:1.14.16.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016715 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] +xref: EC:1.14.17.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016716 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] +xref: EC:1.14.18.- +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016717 +name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] +xref: EC:1.14.19.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016718 +name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" EXACT [] +is_obsolete: true +consider: GO:0016705 + +[Term] +id: GO:0016719 +name: carotene 7,8-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [RHEA:15701] +synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" RELATED [] +synonym: "zeta-carotene desaturase activity" RELATED [EC:1.3.5.6] +xref: EC:1.3.5.6 +xref: MetaCyc:1.14.99.30-RXN +xref: RHEA:15701 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016720 +name: delta12-fatty acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23456] +synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] +synonym: "D12-fatty acid dehydrogenase activity" EXACT [] +synonym: "delta-12 fatty acid acetylenase activity" RELATED [EC:1.14.99.33] +synonym: "delta12 fatty acid acetylenase activity" RELATED [EC:1.14.99.33] +synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] +synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" RELATED [EC:1.14.99.33] +synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" RELATED [EC:1.14.99.33] +xref: EC:1.14.99.33 +xref: KEGG_REACTION:R05740 +xref: MetaCyc:1.14.99.33-RXN +xref: RHEA:23456 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0016721 +name: oxidoreductase activity, acting on superoxide radicals as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] +xref: EC:1.15.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016722 +name: oxidoreductase activity, acting on metal ions +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] +synonym: "oxidoreductase activity, oxidizing metal ions" RELATED [] +synonym: "oxidoreductase activity, reducing metal ions" RELATED [] +xref: EC:1.16.-.- +xref: Reactome:R-HSA-917805 "CYBRD1:Heme reduces Fe3+ to Fe2+" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016723 +name: oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] +synonym: "oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor" RELATED [] +synonym: "oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor" RELATED [] +xref: EC:1.16.1.- +xref: Reactome:R-HSA-917811 "STEAP3-like proteins reduce Fe3+ to Fe2+" +is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions + +[Term] +id: GO:0016724 +name: oxidoreductase activity, acting on metal ions, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] +synonym: "oxidoreductase activity, oxidizing metal ions, oxygen as acceptor" RELATED [] +xref: EC:1.16.3.- +is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions + +[Term] +id: GO:0016725 +name: oxidoreductase activity, acting on CH or CH2 groups +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] +xref: EC:1.17.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016726 +name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] +xref: EC:1.17.1.- +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016727 +name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +xref: EC:1.17.3.- +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016728 +name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] +synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] +xref: EC:1.17.4.- +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0016729 +name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on CH2 groups, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016725 + +[Term] +id: GO:0016730 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] +xref: EC:1.18.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016731 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.18.1.- +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0016732 +name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] +xref: EC:1.18.6.- +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0016733 +name: obsolete iron-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +synonym: "iron-iron nitrogenase activity" EXACT [] +is_obsolete: true +consider: GO:0016163 +consider: GO:0016611 + +[Term] +id: GO:0016734 +name: obsolete molybdenum-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +synonym: "molybdenum-iron nitrogenase activity" EXACT [] +is_obsolete: true +consider: GO:0016163 +consider: GO:0016612 + +[Term] +id: GO:0016735 +name: obsolete vanadium-iron nitrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] +comment: This term was made obsolete because it represents a cellular component. +synonym: "vanadium-iron nitrogenase activity" EXACT [] +is_obsolete: true +consider: GO:0016163 +consider: GO:0016613 + +[Term] +id: GO:0016737 +name: oxidoreductase activity, acting on reduced flavodoxin as donor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +xref: EC:1.19.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016738 +name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] +xref: EC:1.19.6.- +is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor + +[Term] +id: GO:0016739 +name: obsolete oxidoreductase activity, acting on other substrates +namespace: molecular_function +def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on other substrates" EXACT [] +is_obsolete: true +consider: GO:0016491 + +[Term] +id: GO:0016740 +name: transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: EC:2.-.-.- +xref: Reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" +xref: Reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" +xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" +xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016741 +name: transferase activity, transferring one-carbon groups +namespace: molecular_function +def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +synonym: "methyltransferase activity" NARROW [] +xref: EC:2.1.-.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016742 +name: hydroxymethyl-, formyl- and related transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2.-, GOC:mah] +xref: EC:2.1.2.- +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0016743 +name: carboxyl- or carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] +synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] +xref: EC:2.1.3.- +is_a: GO:0016741 ! transferase activity, transferring one-carbon groups + +[Term] +id: GO:0016744 +name: transketolase or transaldolase activity +namespace: molecular_function +alt_id: GO:0016745 +def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +synonym: "transferase activity, transferring aldehyde or ketonic groups" EXACT [] +xref: EC:2.2.1.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016746 +name: acyltransferase activity +namespace: molecular_function +alt_id: GO:0008415 +def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_drosophila +synonym: "transferase activity, transferring acyl groups" EXACT [] +xref: EC:2.3.-.- +xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" +xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" +xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" +xref: Reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" +xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016747 +name: acyltransferase activity, transferring groups other than amino-acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] +synonym: "transferase activity, transferring acyl groups other than amino-acyl groups" EXACT [] +synonym: "transferase activity, transferring groups other than amino-acyl groups" RELATED [EC:2.3.1.-] +xref: EC:2.3.1.- +is_a: GO:0016746 ! acyltransferase activity + +[Term] +id: GO:0016748 +name: succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016749 +name: N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016750 +name: O-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016751 +name: S-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016417 ! S-acyltransferase activity +is_a: GO:0016748 ! succinyltransferase activity + +[Term] +id: GO:0016752 +name: sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0016753 +name: O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016752 ! sinapoyltransferase activity + +[Term] +id: GO:0016754 +name: sinapoylglucose-malate O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12625] +synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" RELATED [EC:2.3.1.92] +synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" RELATED [EC:2.3.1.92] +synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] +xref: EC:2.3.1.92 +xref: KEGG_REACTION:R03323 +xref: MetaCyc:2.3.1.92-RXN +xref: RHEA:12625 +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0016755 +name: aminoacyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] +synonym: "transferase activity, transferring amino-acyl groups" EXACT [] +xref: EC:2.3.2.- +is_a: GO:0016746 ! acyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0016756 +name: glutathione gamma-glutamylcysteinyltransferase activity +namespace: molecular_function +alt_id: GO:0042143 +def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] +synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" RELATED [EC:2.3.2.15] +synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" RELATED [EC:2.3.2.15] +synonym: "phytochelatin synthase activity" RELATED [EC:2.3.2.15] +xref: EC:2.3.2.15 +xref: MetaCyc:2.3.2.15-RXN +xref: RHEA:17917 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0016757 +name: glycosyltransferase activity +namespace: molecular_function +alt_id: GO:0016932 +def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "transferase activity, transferring glycosyl groups" EXACT [] +synonym: "transferase activity, transferring other glycosyl groups" NARROW [] +synonym: "transglycosidase activity" EXACT [] +synonym: "transglycosylase activity" EXACT [] +xref: EC:2.4.-.- +xref: Reactome:R-HSA-5173005 "B3GALTL transfers glucose to O-fucosyl-proteins" +xref: Reactome:R-HSA-6785565 "Defective B3GALTL does not transfer glucose to O-fucosyl-proteins" +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016758 +name: hexosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] +synonym: "transferase activity, transferring hexosyl groups" EXACT [] +xref: EC:2.4.1.- +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0016759 +name: cellulose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] +synonym: "cellulose synthetase activity" RELATED [EC:2.4.1.29] +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0016760 +name: cellulose synthase (UDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] +synonym: "1,4-beta-D-glucan synthase activity" RELATED [EC:2.4.1.12] +synonym: "1,4-beta-glucan synthase activity" RELATED [EC:2.4.1.12] +synonym: "beta-1,4-glucan synthase activity" RELATED [EC:2.4.1.12] +synonym: "beta-1,4-glucan synthetase activity" RELATED [EC:2.4.1.12] +synonym: "beta-1,4-glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "beta-glucan synthase activity" RELATED [EC:2.4.1.12] +synonym: "glucan synthase activity" RELATED [EC:2.4.1.12] +synonym: "GS-I" RELATED [EC:2.4.1.12] +synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDP-glucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDPglucose-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDPglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.12] +synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.12] +xref: EC:2.4.1.12 +xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN +xref: RHEA:19929 +is_a: GO:0016759 ! cellulose synthase activity +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016761 +name: cellulose synthase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] +synonym: "cellulose synthase (guanosine diphosphate-forming) activity" RELATED [EC:2.4.1.29] +synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" RELATED [EC:2.4.1.29] +synonym: "GDP-glucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.29] +synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.29] +synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.29] +synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" RELATED [EC:2.4.1.29] +synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" RELATED [EC:2.4.1.29] +xref: EC:2.4.1.29 +xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN +xref: RHEA:17797 +is_a: GO:0016759 ! cellulose synthase activity + +[Term] +id: GO:0016762 +name: xyloglucan:xyloglucosyl transferase activity +namespace: molecular_function +alt_id: GO:0080039 +def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366] +synonym: "endo-xyloglucan transferase activity" RELATED [EC:2.4.1.207] +synonym: "endoxyloglucan transferase activity" EXACT [] +synonym: "xyloglucan endotransglucosylase activity" RELATED [EC:2.4.1.207] +synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" RELATED [EC:2.4.1.207] +xref: EC:2.4.1.207 +xref: MetaCyc:2.4.1.207-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0016763 +name: pentosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] +synonym: "transferase activity, transferring pentosyl groups" EXACT [] +xref: EC:2.4.2.- +xref: Reactome:R-HSA-112265 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]" +xref: Reactome:R-HSA-112266 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]" +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0016764 +name: obsolete transferase activity, transferring other glycosyl groups +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "transferase activity, transferring other glycosyl groups" EXACT [] +is_obsolete: true +consider: GO:0016757 + +[Term] +id: GO:0016765 +name: transferase activity, transferring alkyl or aryl (other than methyl) groups +namespace: molecular_function +alt_id: GO:0016766 +def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_drosophila +synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] +xref: EC:2.5.1.- +xref: Reactome:R-HSA-4419978 "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP" +xref: Reactome:R-HSA-4755545 "Defective DHDDS does not elongate E,E-FPP" +xref: Reactome:R-HSA-6782893 "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)" +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016767 +name: geranylgeranyl-diphosphate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] +synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.32] +synonym: "phytoene synthetase activity" RELATED [EC:2.5.1.32] +synonym: "prephytoene-diphosphate synthase activity" RELATED [EC:2.5.1.32] +synonym: "PSase activity" RELATED [EC:2.5.1.32] +xref: EC:2.5.1.32 +xref: MetaCyc:2.5.1.32-RXN +xref: RHEA:22296 +is_a: GO:0004337 ! geranyltranstransferase activity + +[Term] +id: GO:0016768 +name: spermine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] +synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.22] +synonym: "spermidine aminopropyltransferase activity" RELATED [EC:2.5.1.22] +synonym: "spermine synthetase activity" RELATED [EC:2.5.1.22] +xref: EC:2.5.1.22 +xref: MetaCyc:SPERMINE-SYNTHASE-RXN +xref: Reactome:R-HSA-351210 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine" +xref: RHEA:19973 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0016769 +name: transferase activity, transferring nitrogenous groups +namespace: molecular_function +def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] +xref: EC:2.6.-.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016771 +name: obsolete transferase activity, transferring other nitrogenous groups +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "transferase activity, transferring other nitrogenous groups" EXACT [] +is_obsolete: true +consider: GO:0016769 + +[Term] +id: GO:0016772 +name: transferase activity, transferring phosphorus-containing groups +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. +subset: goslim_chembl +xref: EC:2.7.-.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016773 +name: phosphotransferase activity, alcohol group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] +subset: goslim_drosophila +xref: EC:2.7.1.- +xref: Reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine" +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016774 +name: phosphotransferase activity, carboxyl group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] +xref: EC:2.7.2.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016775 +name: phosphotransferase activity, nitrogenous group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] +xref: EC:2.7.3.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016776 +name: phosphotransferase activity, phosphate group as acceptor +namespace: molecular_function +def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] +xref: EC:2.7.4.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016778 +name: diphosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, PMID:1651917] +xref: EC:2.7.6.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016779 +name: nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_yeast +xref: EC:2.7.7.- +xref: Reactome:R-HSA-6782434 "THG1L transfers GMP to 5' end of tRNA(His)" +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016780 +name: phosphotransferase activity, for other substituted phosphate groups +namespace: molecular_function +def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl] +xref: EC:2.7.8.- +xref: Reactome:R-HSA-162742 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" +xref: Reactome:R-HSA-163069 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol" +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016781 +name: phosphotransferase activity, paired acceptors +namespace: molecular_function +def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl] +xref: EC:2.7.9.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0016782 +name: transferase activity, transferring sulphur-containing groups +namespace: molecular_function +def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +xref: EC:2.8.-.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016783 +name: sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] +synonym: "sulphurtransferase activity" EXACT [] +synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah] +xref: EC:2.8.1.- +xref: Reactome:R-HSA-1614618 "Persulfide sulfur is transferred onto sulfite" +xref: Reactome:R-HSA-6782264 "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs" +xref: Reactome:R-HSA-947538 "Transfer of sulfur from MOCS3-S-S onto MOCS2A" +is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups + +[Term] +id: GO:0016784 +name: 3-mercaptopyruvate sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] +synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] +synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" RELATED [EC:2.8.1.2] +synonym: "beta-mercaptopyruvate sulfurtransferase activity" RELATED [EC:2.8.1.2] +synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] +xref: EC:2.8.1.2 +xref: MetaCyc:MERCAPYSTRANS-RXN +xref: Reactome:R-HSA-9012721 "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR" +xref: Reactome:R-HSA-9013471 "MPST transfers sulfur from 3MPYR to HCN to form HSCN" +xref: Reactome:R-HSA-9013533 "MPST transfers sulfur from sulfanegen to HCN to form HSCN" +xref: Reactome:R-HSA-9034756 "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST" +xref: RHEA:21740 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0016785 +name: selenotransferase activity +namespace: molecular_function +alt_id: GO:0016786 +def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] +synonym: "transferase activity, transferring selenium-containing groups" EXACT [] +xref: EC:2.9.1.- +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0016787 +name: hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +xref: EC:3.-.-.- +xref: Reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" +xref: Reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" +xref: Reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" +xref: Reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" +xref: Reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" +xref: Reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" +xref: Reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" +xref: Reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016788 +name: hydrolase activity, acting on ester bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] +subset: goslim_chembl +synonym: "esterase activity" EXACT [] +xref: EC:3.1.-.- +xref: Reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid" +xref: Reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" +xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016790 +name: thiolester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [EC:3.1.2.-] +synonym: "thiolesterase activity" EXACT [] +xref: EC:3.1.2.- +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0016791 +name: phosphatase activity +namespace: molecular_function +alt_id: GO:0003869 +alt_id: GO:0016302 +def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:curators, GOC:pg] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_yeast +synonym: "4-nitrophenylphosphatase activity" NARROW [] +synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [] +synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [] +synonym: "K-pNPPase activity" NARROW [] +synonym: "nitrophenyl phosphatase activity" NARROW [] +synonym: "NPPase activity" NARROW [] +synonym: "p-nitrophenylphosphatase activity" NARROW [] +synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [] +synonym: "para-nitrophenyl phosphatase activity" NARROW [] +synonym: "phosphatase" RELATED [] +synonym: "phosphoric monoester hydrolase activity" EXACT [] +synonym: "PNPPase activity" NARROW [] +xref: EC:3.1.3.- +xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN +xref: Reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" +xref: Reactome:R-HSA-9636457 "SapM dephosphorylates PI3P" +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016793 +name: triphosphoric monoester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] +xref: EC:3.1.5.- +xref: Reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate" +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016794 +name: diphosphoric monoester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] +xref: EC:3.1.7.- +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016795 +name: phosphoric triester hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8.-, GOC:curators] +xref: EC:3.1.8.- +is_a: GO:0042578 ! phosphoric ester hydrolase activity + +[Term] +id: GO:0016796 +name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.15.- +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0016797 +name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +xref: EC:3.1.16.- +is_a: GO:0004527 ! exonuclease activity + +[Term] +id: GO:0016798 +name: hydrolase activity, acting on glycosyl bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "glycosidase activity" EXACT [] +synonym: "glycosylase" NARROW [] +synonym: "N-glycosylase" NARROW [] +xref: EC:3.2.-.- +xref: Reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" +xref: Reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016799 +name: hydrolase activity, hydrolyzing N-glycosyl compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] +xref: EC:3.2.2.- +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:0016801 +name: hydrolase activity, acting on ether bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] +xref: EC:3.3.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016802 +name: trialkylsulfonium hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] +synonym: "thioether hydrolase activity" EXACT [] +synonym: "trialkylsulphonium hydrolase activity" EXACT [] +xref: EC:3.3.1.- +is_a: GO:0016801 ! hydrolase activity, acting on ether bonds + +[Term] +id: GO:0016803 +name: ether hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] +xref: EC:3.3.2.- +xref: Reactome:R-HSA-8874435 "THEM86B hydrolyses PMCHO, PMETAM" +is_a: GO:0016801 ! hydrolase activity, acting on ether bonds + +[Term] +id: GO:0016804 +name: obsolete prolyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] +comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. +synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] +synonym: "Pro-X aminopeptidase activity" RELATED [EC:3.4.11.5] +synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] +synonym: "proline iminopeptidase activity" EXACT [] +synonym: "prolyl aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0016805 +name: dipeptidase activity +namespace: molecular_function +alt_id: GO:0102008 +def: "Catalysis of the hydrolysis of a dipeptide." [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002] +synonym: "cytosolic dipeptidase activity" NARROW [] +xref: EC:3.4.13.- +xref: Reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2" +xref: Reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG" +xref: Reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG" +xref: Reactome:R-HSA-9026771 "DPEP hydrolyses MCTR2 to MCTR3" +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0016806 +name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] +comment: This term was made obsolete because it represents two activities. +synonym: "dipeptidyl-peptidase and tripeptidyl-peptidase activity" EXACT [] +xref: EC:3.4.14.- +is_obsolete: true + +[Term] +id: GO:0016807 +name: cysteine-type carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE] +xref: EC:3.4.18.- +xref: MetaCyc:3.4.18.1-RXN +is_a: GO:0004180 ! carboxypeptidase activity +is_a: GO:0070004 ! cysteine-type exopeptidase activity + +[Term] +id: GO:0016808 +name: obsolete proprotein convertase activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "proprotein convertase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0016810 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] +subset: goslim_chembl +subset: goslim_drosophila +synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] +xref: EC:3.5.-.- +xref: Reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016811 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] +xref: EC:3.5.1.- +xref: Reactome:R-HSA-9673053 "PM20D1 transforms oleoyl-phe from oleate and phe" +xref: Reactome:R-HSA-9673054 "PM20D1 hydrolyzes oleoyl-phe" +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016812 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] +xref: EC:3.5.2.- +xref: Reactome:R-HSA-70906 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+" +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016813 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] +xref: EC:3.5.3.- +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016814 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] +xref: EC:3.5.4.- +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016815 +name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [GOC:curators] +xref: EC:3.5.5.- +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0016816 +name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" EXACT [] +is_obsolete: true +consider: GO:0016810 + +[Term] +id: GO:0016817 +name: hydrolase activity, acting on acid anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] +synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] +xref: EC:3.6.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016818 +name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] +xref: EC:3.6.1.- +is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides + +[Term] +id: GO:0016819 +name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] +synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] +xref: EC:3.6.2.- +is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides + +[Term] +id: GO:0016821 +name: obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it incorporates process information. +synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" EXACT [] +is_obsolete: true +replaced_by: GO:0016817 + +[Term] +id: GO:0016822 +name: hydrolase activity, acting on acid carbon-carbon bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] +xref: EC:3.7.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016823 +name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] +xref: EC:3.7.1.- +is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds + +[Term] +id: GO:0016824 +name: hydrolase activity, acting on acid halide bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] +xref: EC:3.8.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016825 +name: hydrolase activity, acting on acid phosphorus-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] +xref: EC:3.9.1.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016826 +name: hydrolase activity, acting on acid sulfur-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] +synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] +xref: EC:3.10.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016827 +name: hydrolase activity, acting on acid carbon-phosphorus bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] +xref: EC:3.11.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016828 +name: hydrolase activity, acting on acid sulfur-sulfur bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] +synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] +xref: EC:3.12.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0016829 +name: lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [ISBN:0198547684] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_yeast +synonym: "other lyase activity" NARROW [] +xref: EC:4.-.-.- +xref: Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL" +xref: Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016830 +name: carbon-carbon lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] +synonym: "other carbon-carbon lyase activity" NARROW [] +xref: EC:4.1.-.- +xref: Reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA" +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016831 +name: carboxy-lyase activity +namespace: molecular_function +def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [GOC:curators] +synonym: "decarboxylase activity" EXACT [] +xref: EC:4.1.1.- +xref: Reactome:R-HSA-6787757 "PXLP-K333-GADL1 decarboxylates acidic AAs" +xref: Reactome:R-HSA-6814165 "PXLP-K333-GADL1 decarboxylates CSA to HTAU" +xref: Reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2" +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016832 +name: aldehyde-lyase activity +namespace: molecular_function +alt_id: GO:0016228 +def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [GOC:curators] +synonym: "aldolase activity" BROAD [] +xref: EC:4.1.2.- +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016833 +name: oxo-acid-lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3.-, GOC:jl] +synonym: "oxo-acid lyase activity" EXACT [] +synonym: "oxoacid lyase activity" EXACT [] +xref: EC:4.1.3.- +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0016834 +name: obsolete other carbon-carbon lyase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other carbon-carbon lyase activity" EXACT [] +is_obsolete: true +consider: GO:0016830 + +[Term] +id: GO:0016835 +name: carbon-oxygen lyase activity +namespace: molecular_function +def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] +synonym: "other carbon-oxygen lyase activity" NARROW [] +xref: EC:4.2.-.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016836 +name: hydro-lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1.-] +xref: EC:4.2.1.- +xref: Reactome:R-HSA-9014627 "SDS dimers:PXLP dehydrate L-Thr to 2AA" +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016837 +name: carbon-oxygen lyase activity, acting on polysaccharides +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] +xref: EC:4.2.2.- +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016838 +name: carbon-oxygen lyase activity, acting on phosphates +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.3.-] +xref: EC:4.2.3.- +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0016839 +name: obsolete other carbon-oxygen lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other carbon-oxygen lyase activity" EXACT [] +is_obsolete: true +consider: GO:0016835 + +[Term] +id: GO:0016840 +name: carbon-nitrogen lyase activity +namespace: molecular_function +def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] +synonym: "other carbon-nitrogen lyase activity" NARROW [] +xref: EC:4.3.-.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016841 +name: ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] +xref: EC:4.3.1.- +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016842 +name: amidine-lyase activity +namespace: molecular_function +def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] +xref: EC:4.3.2.- +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016843 +name: amine-lyase activity +namespace: molecular_function +def: "Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] +xref: EC:4.3.3.- +is_a: GO:0016840 ! carbon-nitrogen lyase activity + +[Term] +id: GO:0016844 +name: strictosidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15013] +synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" RELATED [EC:4.3.3.2] +synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" RELATED [EC:4.3.3.2] +synonym: "STR activity" RELATED [EC:4.3.3.2] +synonym: "strictosidine synthetase activity" RELATED [EC:4.3.3.2] +xref: EC:4.3.3.2 +xref: KEGG_REACTION:R03738 +xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN +xref: RHEA:15013 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0016845 +name: obsolete other carbon-nitrogen lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other carbon-nitrogen lyase activity" EXACT [] +is_obsolete: true +consider: GO:0016840 + +[Term] +id: GO:0016846 +name: carbon-sulfur lyase activity +namespace: molecular_function +def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-] +synonym: "carbon-sulphur lyase activity" EXACT [] +xref: EC:4.4.-.- +xref: Reactome:R-HSA-1614567 "Excess homocysteine yields homolanthionine and H2S" +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016847 +name: 1-aminocyclopropane-1-carboxylate synthase activity +namespace: molecular_function +alt_id: GO:0034100 +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21744] +comment: Note that this function was formerly EC:4.1.99.4. +synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" RELATED [EC:4.4.1.14] +synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" RELATED [EC:4.4.1.14] +synonym: "1-aminocyclopropanecarboxylate synthase activity" RELATED [EC:4.4.1.14] +synonym: "ACC synthase activity" RELATED [EC:4.4.1.14] +synonym: "aminocyclopropanecarboxylate synthase activity" RELATED [EC:4.4.1.14] +synonym: "aminocyclopropanecarboxylic acid synthase activity" RELATED [EC:4.4.1.14] +synonym: "L-VG deaminase activity" RELATED [PMID:11470512] +synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512] +synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" RELATED [EC:4.4.1.14] +synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" RELATED [EC:4.4.1.14] +xref: EC:4.4.1.14 +xref: KEGG_REACTION:R00179 +xref: MetaCyc:4.4.1.14-RXN +xref: RHEA:21744 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0016848 +name: carbon-halide lyase activity +namespace: molecular_function +def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] +xref: EC:4.5.-.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016849 +name: phosphorus-oxygen lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] +xref: EC:4.6.-.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016850 +name: obsolete other lyase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other lyase activity" EXACT [] +is_obsolete: true +consider: GO:0016829 + +[Term] +id: GO:0016851 +name: magnesium chelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13961] +comment: Note that this was EC:4.99.1.1. +synonym: "magnesium-chelatase activity" RELATED [EC:6.6.1.1] +synonym: "magnesium-protoporphyrin chelatase activity" RELATED [EC:6.6.1.1] +synonym: "magnesium-protoporphyrin IX chelatase activity" RELATED [EC:6.6.1.1] +synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX chelatase activity" RELATED [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX magnesio-lyase activity" RELATED [EC:6.6.1.1] +synonym: "Mg-protoporphyrin IX magnesium-lyase activity" RELATED [EC:6.6.1.1] +synonym: "protoporphyrin IX magnesium-chelatase activity" RELATED [EC:6.6.1.1] +synonym: "protoporphyrin IX Mg-chelatase activity" RELATED [EC:6.6.1.1] +xref: EC:6.6.1.1 +xref: KEGG_REACTION:R03877 +xref: MetaCyc:RXN1F-20 +xref: RHEA:13961 +is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes + +[Term] +id: GO:0016852 +name: sirohydrochlorin cobaltochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [RHEA:15893] +synonym: "anaerobic cobalt chelatase activity" EXACT [EC:4.99.1.3] +synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" RELATED [] +synonym: "cobaltochelatase" EXACT [EC:4.99.1.3] +synonym: "sirohydrochlorin cobalt-lyase activity" RELATED [] +xref: EC:4.99.1.3 +xref: MetaCyc:4.99.1.3-RXN +xref: RHEA:15893 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0016853 +name: isomerase activity +namespace: molecular_function +def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_yeast +synonym: "other isomerase activity" NARROW [] +xref: EC:5.-.-.- +xref: Reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016854 +name: racemase and epimerase activity +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732] +comment: Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. +synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] +xref: EC:5.1.-.- +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016855 +name: racemase and epimerase activity, acting on amino acids and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] +xref: EC:5.1.1.- +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016856 +name: racemase and epimerase activity, acting on hydroxy acids and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] +xref: EC:5.1.2.- +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016857 +name: racemase and epimerase activity, acting on carbohydrates and derivatives +namespace: molecular_function +def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] +xref: EC:5.1.3.- +xref: Reactome:R-HSA-6787677 "FUOM isomerises alpha-Fuc to beta-Fuc" +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0016858 +name: obsolete racemase and epimerase activity, acting on other compounds +namespace: molecular_function +def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "racemase and epimerase activity, acting on other compounds" EXACT [] +is_obsolete: true +consider: GO:0016854 + +[Term] +id: GO:0016859 +name: cis-trans isomerase activity +namespace: molecular_function +def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732] +xref: EC:5.2.-.- +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016860 +name: intramolecular oxidoreductase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-, GOC:curators] +synonym: "intramolecular isomerase activity" EXACT [] +synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] +xref: EC:5.3.-.- +xref: Reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016861 +name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl] +synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] +xref: EC:5.3.1.- +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016862 +name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl] +synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] +xref: EC:5.3.2.- +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016863 +name: intramolecular oxidoreductase activity, transposing C=C bonds +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3.-, GOC:mah] +synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] +xref: EC:5.3.3.- +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016864 +name: intramolecular oxidoreductase activity, transposing S-S bonds +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4.-, GOC:mah] +synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] +xref: EC:5.3.4.- +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0016865 +name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases +namespace: molecular_function +def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT [] +synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" EXACT [] +is_obsolete: true +consider: GO:0016860 + +[Term] +id: GO:0016866 +name: intramolecular transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] +synonym: "intramolecular transferase activity, transferring other groups" NARROW [] +synonym: "mutase activity" EXACT [] +xref: EC:5.4.-.- +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016867 +name: intramolecular transferase activity, transferring acyl groups +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] +xref: EC:5.4.1.- +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016868 +name: intramolecular transferase activity, phosphotransferases +namespace: molecular_function +alt_id: GO:0016777 +def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] +synonym: "phosphomutase activity" EXACT [] +synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT [] +xref: EC:5.4.2.- +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016869 +name: intramolecular transferase activity, transferring amino groups +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] +xref: EC:5.4.3.- +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0016870 +name: obsolete intramolecular transferase activity, transferring other groups +namespace: molecular_function +def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "intramolecular transferase activity, transferring other groups" EXACT [] +is_obsolete: true +consider: GO:0016866 + +[Term] +id: GO:0016871 +name: cycloartenol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21308] +synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" RELATED [EC:5.4.99.8] +synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" RELATED [EC:5.4.99.8] +synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" RELATED [EC:5.4.99.8] +synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" RELATED [EC:5.4.99.8] +synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] +synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" RELATED [EC:5.4.99.8] +xref: EC:5.4.99.8 +xref: KEGG_REACTION:R03200 +xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN +xref: RHEA:21308 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0016872 +name: intramolecular lyase activity +namespace: molecular_function +def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl] +xref: EC:5.5.1.- +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0016873 +name: obsolete other isomerase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other isomerase activity" EXACT [] +is_obsolete: true +consider: GO:0016853 + +[Term] +id: GO:0016874 +name: ligase activity +namespace: molecular_function +def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [EC:6.-.-.-, GOC:mah] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_yeast +synonym: "synthetase activity" EXACT [GOC:jh2] +xref: EC:6.-.-.- +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0016875 +name: ligase activity, forming carbon-oxygen bonds +namespace: molecular_function +def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1.-.-, GOC:mah] +xref: EC:6.1.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016877 +name: ligase activity, forming carbon-sulfur bonds +namespace: molecular_function +def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-, GOC:mah] +synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] +xref: EC:6.2.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016878 +name: acid-thiol ligase activity +namespace: molecular_function +def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1.-, GOC:mah] +xref: EC:6.2.1.- +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0016879 +name: ligase activity, forming carbon-nitrogen bonds +namespace: molecular_function +def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] +synonym: "other carbon-nitrogen ligase activity" NARROW [] +xref: EC:6.3.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016880 +name: acid-ammonia (or amide) ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] +synonym: "amide synthase activity" EXACT [] +xref: EC:6.3.1.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016881 +name: acid-amino acid ligase activity +namespace: molecular_function +def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] +synonym: "peptide synthase activity" EXACT [] +xref: EC:6.3.2.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016882 +name: cyclo-ligase activity +namespace: molecular_function +def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah] +xref: EC:6.3.3.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016883 +name: obsolete other carbon-nitrogen ligase activity +namespace: molecular_function +def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "other carbon-nitrogen ligase activity" EXACT [] +is_obsolete: true +consider: GO:0016879 + +[Term] +id: GO:0016884 +name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor +namespace: molecular_function +alt_id: GO:0016003 +def: "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532] +xref: EC:6.3.5.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0016885 +name: ligase activity, forming carbon-carbon bonds +namespace: molecular_function +def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4.-.-, GOC:jl, GOC:mah] +xref: EC:6.4.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016886 +name: ligase activity, forming phosphoric ester bonds +namespace: molecular_function +def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5.-.-, GOC:mah] +xref: EC:6.5.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0016887 +name: ATP hydrolysis activity +namespace: molecular_function +alt_id: GO:0004002 +alt_id: GO:0042623 +def: "Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] +comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATPase as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. +synonym: "adenosine 5'-triphosphatase activity" EXACT [] +synonym: "adenosine triphosphatase activity" EXACT [] +synonym: "adenosinetriphosphatase activity" EXACT [] +synonym: "ATP hydrolase activity" EXACT [] +synonym: "ATP monophosphatase activity" RELATED [] +synonym: "ATP phosphohydrolase activity" EXACT [] +xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" +xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" +xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" +xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" +xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" +xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" +xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" +xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" +xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" +xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" +xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" +xref: Reactome:R-HSA-72139 "Formation of the active Spliceosomal C (B*) complex" +xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" +xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" +xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" +xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" +xref: Reactome:R-HSA-917693 "ESCRT Disassembly" +xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" +xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" +xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP" +xref: RHEA:13065 +is_a: GO:0017111 ! nucleoside-triphosphatase activity +relationship: part_of GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0016888 +name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] +synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.21.- +xref: Reactome:R-HSA-912368 "SPO11 hydrolyzes DNA forming double-strand breaks" +is_a: GO:0004520 ! endodeoxyribonuclease activity +is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016889 +name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] +synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] +xref: EC:3.1.22.- +is_a: GO:0004520 ! endodeoxyribonuclease activity +is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016890 +name: site-specific endodeoxyribonuclease activity, specific for altered base +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] +xref: EC:3.1.25.- +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0016891 +name: endoribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] +xref: EC:3.1.26.- +is_a: GO:0004521 ! endoribonuclease activity +is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016892 +name: endoribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] +synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] +xref: EC:3.1.27.- +is_a: GO:0004521 ! endoribonuclease activity +is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016893 +name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +synonym: "5'-endonuclease activity" EXACT [] +synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] +xref: EC:3.1.30.- +is_a: GO:0004519 ! endonuclease activity + +[Term] +id: GO:0016894 +name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] +comment: Note that this activity can catalyze cleavage of DNA or RNA. +synonym: "3'-endonuclease activity" EXACT [] +synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] +xref: EC:3.1.31.- +is_a: GO:0004519 ! endonuclease activity + +[Term] +id: GO:0016895 +name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +alt_id: GO:0008858 +def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] +synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] +synonym: "exonuclease VIII activity" NARROW [] +xref: EC:3.1.11.- +is_a: GO:0004529 ! exodeoxyribonuclease activity +is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016896 +name: exoribonuclease activity, producing 5'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] +synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] +xref: EC:3.1.13.- +xref: Reactome:R-HSA-429860 "DCP1-DCP2 complex decaps mRNA" +is_a: GO:0004532 ! exoribonuclease activity +is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + +[Term] +id: GO:0016897 +name: exoribonuclease activity, producing 3'-phosphomonoesters +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] +xref: EC:3.1.14.- +is_a: GO:0004532 ! exoribonuclease activity +is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + +[Term] +id: GO:0016898 +name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] +xref: EC:1.1.2.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016899 +name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] +xref: EC:1.1.3.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016900 +name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] +synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] +xref: EC:1.1.4.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016901 +name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] +xref: EC:1.1.5.- +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0016902 +name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" EXACT [] +is_obsolete: true +consider: GO:0016614 + +[Term] +id: GO:0016903 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] +synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] +xref: EC:1.2.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0016905 +name: myosin heavy chain kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] +synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" RELATED [EC:2.7.11.7] +synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" RELATED [EC:2.7.11.7] +synonym: "calmodulin-dependent myosin heavy chain kinase activity" RELATED [EC:2.7.11.7] +synonym: "MHCK" RELATED [EC:2.7.11.7] +synonym: "MIHC kinase activity" RELATED [EC:2.7.11.7] +synonym: "myosin heavy chain kinase A activity" RELATED [EC:2.7.11.7] +synonym: "myosin heavy-chain kinase activity" RELATED [EC:2.7.11.7] +synonym: "myosin I heavy chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin II heavy chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] +synonym: "myosin-heavy-chain kinase activity" RELATED [EC:2.7.11.7] +synonym: "STK6" RELATED [EC:2.7.11.7] +xref: EC:2.7.11.7 +xref: RHEA:11424 +is_a: GO:0004683 ! calmodulin-dependent protein kinase activity + +[Term] +id: GO:0016906 +name: sterol 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173, RHEA:22724] +synonym: "sterol 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "sterol glucosyltransferase activity" EXACT [] +synonym: "sterol-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "UDP-glucose-sterol glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] +synonym: "UDPG-SGTase activity" RELATED [EC:2.4.1.173] +synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] +synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" RELATED [EC:2.4.1.173] +synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" RELATED [EC:2.4.1.173] +xref: EC:2.4.1.173 +xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:22724 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0016907 +name: G protein-coupled acetylcholine receptor activity +namespace: molecular_function +alt_id: GO:0004981 +def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] +synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf] +synonym: "G protein coupled acetylcholine receptor activity" EXACT [] +synonym: "G-protein coupled acetylcholine receptor activity" EXACT [] +synonym: "metabotropic acetylcholine receptor activity" EXACT [] +synonym: "muscarinic acetylcholine receptor activity" EXACT [] +is_a: GO:0008227 ! G protein-coupled amine receptor activity +is_a: GO:0015464 ! acetylcholine receptor activity +is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity + +[Term] +id: GO:0016910 +name: obsolete SAP kinase 3 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a gene product. +synonym: "SAP kinase 3 activity" EXACT [] +synonym: "SAPK3" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0007254 + +[Term] +id: GO:0016911 +name: obsolete SAP kinase 4 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a gene product. +synonym: "SAP kinase 4 activity" EXACT [] +synonym: "SAPK4" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0007254 + +[Term] +id: GO:0016912 +name: obsolete SAP kinase 5 activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product. +synonym: "SAP kinase 5 activity" EXACT [] +synonym: "SAPK5" EXACT [] +is_obsolete: true +consider: GO:0004674 +consider: GO:0007254 + +[Term] +id: GO:0016913 +name: follicle-stimulating hormone activity +namespace: molecular_function +def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684] +synonym: "follicle stimulating hormone activity" EXACT [] +synonym: "follitropin activity" EXACT [ISBN:0198506732] +synonym: "FSH activity" EXACT [GOC:mah] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0016914 +name: follicle-stimulating hormone complex +namespace: cellular_component +def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] +synonym: "follicle stimulating hormone complex" EXACT [] +synonym: "FSH complex" EXACT [] +is_a: GO:0061696 ! pituitary gonadotropin complex + +[Term] +id: GO:0016915 +name: obsolete activin +namespace: molecular_function +def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +synonym: "activin" EXACT [] +is_obsolete: true +consider: GO:0005160 +consider: GO:0046881 + +[Term] +id: GO:0016916 +name: obsolete inhibin +namespace: molecular_function +def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] +comment: This term was made obsolete because it represents a gene product. +synonym: "inhibin" EXACT [] +is_obsolete: true +consider: GO:0005160 +consider: GO:0046882 + +[Term] +id: GO:0016917 +name: GABA receptor activity +namespace: molecular_function +def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650] +comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. +synonym: "4-aminobutanoate receptor activity" EXACT [] +synonym: "4-aminobutyrate receptor activity" EXACT [] +synonym: "GABA binding" EXACT [] +synonym: "gamma-aminobutyrate binding" EXACT [] +synonym: "gamma-aminobutyric acid binding" EXACT [] +synonym: "gamma-aminobutyric acid receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0016918 +name: retinal binding +namespace: molecular_function +def: "Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [ISBN:0198506732] +synonym: "blue-sensitive opsin" RELATED [] +synonym: "green-sensitive opsin" RELATED [] +synonym: "long-wave-sensitive opsin" RELATED [] +synonym: "opsin" RELATED [] +synonym: "red-sensitive opsin" RELATED [] +synonym: "retinaldehyde binding" EXACT [] +synonym: "short-wave-sensitive opsin" RELATED [] +synonym: "UV-sensitive opsin" RELATED [] +synonym: "violet-sensitive opsin" RELATED [] +synonym: "vitamin A binding" BROAD [] +is_a: GO:0005501 ! retinoid binding +is_a: GO:0019842 ! vitamin binding + +[Term] +id: GO:0016919 +name: obsolete nardilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "N-arginine dibasic convertase activity" RELATED [] +synonym: "nardilysin activity" EXACT [] +synonym: "NRD convertase activity" RELATED [] +synonym: "NRD-convertase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0016920 +name: pyroglutamyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] +xref: EC:3.4.19.- +is_a: GO:0008234 ! cysteine-type peptidase activity +is_a: GO:0008242 ! omega peptidase activity + +[Term] +id: GO:0016921 +name: obsolete pyroglutamyl-peptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "PAP-II activity" RELATED [EC:3.4.19.6] +synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] +synonym: "pyroglutamyl aminopeptidase II activity" RELATED [EC:3.4.19.6] +synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] +synonym: "pyroglutamyl-peptidase II activity" EXACT [] +synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" RELATED [EC:3.4.19.6] +synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] +synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" RELATED [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone-degrading peptidase activity" RELATED [EC:3.4.19.6] +synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" RELATED [EC:3.4.19.6] +synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] +synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] +synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] +xref: EC:3.4.19.6 +xref: MetaCyc:3.4.19.6-RXN +is_obsolete: true +consider: GO:0008237 +consider: GO:0016920 + +[Term] +id: GO:0016922 +name: nuclear receptor binding +namespace: molecular_function +alt_id: GO:0035257 +alt_id: GO:0035258 +def: "Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand." [PMID:7776974] +synonym: "ligand-dependent nuclear receptor binding" EXACT [] +synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] +synonym: "nuclear hormone receptor binding" EXACT [] +synonym: "steroid hormone receptor binding" BROAD [] +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0016923 +name: obsolete ligand-dependent thyroid hormone receptor interactor activity +namespace: molecular_function +def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "ligand-dependent thyroid hormone receptor interactor activity" EXACT [] +synonym: "TRIP4" RELATED [] +is_obsolete: true +consider: GO:0046966 + +[Term] +id: GO:0016925 +name: protein sumoylation +namespace: biological_process +alt_id: GO:0006485 +alt_id: GO:0016927 +alt_id: GO:0019947 +alt_id: GO:0019951 +def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] +synonym: "protein sumolation" EXACT [] +synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] +synonym: "Smt3-protein conjugation" RELATED [] +synonym: "Smt3p-protein conjugation" RELATED [] +synonym: "SUMO-protein conjugation" EXACT [] +synonym: "sumoylation" EXACT [] +xref: Wikipedia:SUMO_protein +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0016926 +name: protein desumoylation +namespace: biological_process +alt_id: GO:0016928 +def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] +synonym: "desumoylation" EXACT [] +synonym: "protein desumolation" EXACT [] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0070646 ! protein modification by small protein removal + +[Term] +id: GO:0016929 +name: SUMO-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within SUMO, or between the SUMO and a larger protein to which it has been conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] +comment: This term should not be used for direct manual annotation because the supporting experiments should always distinguish whether the activity is part of maturation or SUMO removal. +subset: gocheck_do_not_manually_annotate +synonym: "SUSP" NARROW [] +synonym: "ULP" NARROW [] +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0016933 +name: extracellularly glycine-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "extracellular-glycine-gated ion channel activity" EXACT [] +synonym: "glycine receptor" BROAD [] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity + +[Term] +id: GO:0016934 +name: extracellularly glycine-gated chloride channel activity +namespace: molecular_function +alt_id: GO:0004891 +def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "extracellular-glycine-gated chloride channel activity" EXACT [] +synonym: "glycine receptor" BROAD [] +synonym: "glycine-inhibited chloride channel activity" RELATED [] +xref: Reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol" +is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0016933 ! extracellularly glycine-gated ion channel activity +is_a: GO:0099095 ! ligand-gated anion channel activity + +[Term] +id: GO:0016935 +name: glycine-gated chloride channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034707 ! chloride channel complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0016936 +name: galactoside binding +namespace: molecular_function +def: "Binding to a glycoside in which the sugar group is galactose." [GOC:jl, ISBN:0198506732] +subset: goslim_chembl +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0016937 +name: short-branched-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah] +xref: EC:1.3.99.- +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0016938 +name: kinesin I complex +namespace: cellular_component +def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0016939 +name: kinesin II complex +namespace: cellular_component +def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] +is_a: GO:0005871 ! kinesin complex + +[Term] +id: GO:0016941 +name: natriuretic peptide receptor activity +namespace: molecular_function +def: "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling] +is_a: GO:0001653 ! peptide receptor activity + +[Term] +id: GO:0016942 +name: insulin-like growth factor binding protein complex +namespace: cellular_component +def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] +subset: goslim_pir +synonym: "IGF binding protein complex" EXACT [] +is_a: GO:0036454 ! growth factor complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0016943 +name: obsolete RNA polymerase I transcription elongation factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol I transcription elongation factor activity" EXACT [] +synonym: "RNA polymerase I transcription elongation factor activity" EXACT [] +is_obsolete: true +consider: GO:0006362 + +[Term] +id: GO:0016944 +name: obsolete RNA polymerase II transcription elongation factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol II transcription elongation factor activity" EXACT [] +synonym: "RNA polymerase II transcription elongation factor activity" EXACT [] +is_obsolete: true +consider: GO:0006368 + +[Term] +id: GO:0016945 +name: obsolete RNA polymerase III transcription elongation factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "Pol III transcription elongation factor activity" EXACT [] +synonym: "RNA polymerase III transcription elongation factor activity" EXACT [] +is_obsolete: true +consider: GO:0006385 + +[Term] +id: GO:0016946 +name: obsolete cathepsin F activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] +comment: This term was made obsolete because it represents a gene product. +synonym: "cathepsin F activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0016962 +name: obsolete receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes a gene product and not a molecular function. +synonym: "receptor-associated protein activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0016963 +name: obsolete alpha-2 macroglobulin receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "alpha-2 macroglobulin receptor-associated protein activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0016964 +name: alpha-2 macroglobulin receptor activity +namespace: molecular_function +def: "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0016966 +name: nitric oxide reductase activity +namespace: molecular_function +alt_id: GO:0016967 +alt_id: GO:0016968 +def: "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5] +synonym: "CYP55" NARROW [] +synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] +synonym: "nitric-oxide reductase activity" RELATED [EC:1.7.2.5] +synonym: "nitrogen oxide reductase activity" RELATED [EC:1.7.2.5] +synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" RELATED [EC:1.7.2.5] +synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" RELATED [EC:1.7.2.5] +synonym: "P450 nitric oxide reductase activity" NARROW [] +synonym: "P450nor" NARROW [] +xref: EC:1.7.2.5 +xref: KEGG_REACTION:R00294 +xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN +xref: RHEA:30211 +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0016969 +name: obsolete hemerythrin +namespace: molecular_function +def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "hemerythrin" EXACT [] +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0016970 +name: obsolete hemocyanin +namespace: molecular_function +def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "hemocyanin" EXACT [] +is_obsolete: true +replaced_by: GO:0005344 + +[Term] +id: GO:0016971 +name: flavin-linked sulfhydryl oxidase activity +namespace: molecular_function +def: "Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor." [PMID:10899311] +is_a: GO:0015035 ! protein-disulfide reductase activity +is_a: GO:0016972 ! thiol oxidase activity + +[Term] +id: GO:0016972 +name: thiol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2." [RHEA:17357] +synonym: "sulfhydryl oxidase activity" RELATED [EC:1.8.3.2] +synonym: "thiol:oxygen oxidoreductase activity" RELATED [EC:1.8.3.2] +xref: EC:1.8.3.2 +xref: MetaCyc:THIOL-OXIDASE-RXN +xref: RHEA:17357 +xref: UM-BBD_reactionID:r1293 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0016973 +name: poly(A)+ mRNA export from nucleus +namespace: biological_process +def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] +synonym: "poly(A) mRNA export from nucleus" EXACT [] +synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] +synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] +synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "poly(A)+ mRNA-nucleus export" EXACT [] +synonym: "polyadenylated mRNA export from nucleus" RELATED [] +is_a: GO:0006406 ! mRNA export from nucleus + +[Term] +id: GO:0016975 +name: obsolete alpha-2 macroglobulin +namespace: molecular_function +def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-2 macroglobulin" EXACT [] +is_obsolete: true +replaced_by: GO:0004866 + +[Term] +id: GO:0016977 +name: chitosanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] +synonym: "chitosan N-acetylglucosaminohydrolase activity" RELATED [EC:3.2.1.132] +xref: EC:3.2.1.132 +xref: MetaCyc:3.2.1.132-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016979 +name: lipoate-protein ligase activity +namespace: molecular_function +alt_id: GO:0008916 +alt_id: GO:0016978 +alt_id: GO:0102315 +def: "Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP." [RHEA:49288] +synonym: "lipoate-protein ligase A activity" NARROW [] +synonym: "lipoate-protein ligase activity (lipoylation of glycine cleavage complex)" NARROW [] +synonym: "lipoate-protein ligase B activity" NARROW [] +xref: EC:6.3.1.20 +xref: MetaCyc:RXN-13039 +xref: MetaCyc:RXN-8654 +xref: MetaCyc:RXN-8655 +xref: MetaCyc:RXN0-1141 +xref: RHEA:49288 +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0016980 +name: creatinase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea." [EC:3.5.3.3, RHEA:22456] +synonym: "creatine amidinohydrolase activity" RELATED [EC:3.5.3.3] +xref: EC:3.5.3.3 +xref: KEGG_REACTION:R01566 +xref: MetaCyc:CREATINASE-RXN +xref: RHEA:22456 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016984 +name: ribulose-bisphosphate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O." [RHEA:23124] +synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] +synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] +synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] +synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] +synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] +synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] +xref: EC:4.1.1.39 +xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN +xref: RHEA:23124 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0016985 +name: mannan endo-1,4-beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] +synonym: "1,4-beta-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.78] +synonym: "beta-1,4-mannan 4-mannanohydrolase activity" RELATED [EC:3.2.1.78] +synonym: "beta-D-mannanase activity" RELATED [EC:3.2.1.78] +synonym: "beta-mannanase activity" BROAD [EC:3.2.1.78] +synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] +synonym: "endo-1,4-beta-mannanase activity" RELATED [EC:3.2.1.78] +synonym: "endo-1,4-mannanase activity" BROAD [EC:3.2.1.78] +synonym: "endo-beta-1,4-mannase activity" RELATED [EC:3.2.1.78] +synonym: "endo-beta-mannanase activity" BROAD [EC:3.2.1.78] +xref: EC:3.2.1.78 +xref: MetaCyc:3.2.1.78-RXN +is_a: GO:0004567 ! beta-mannosidase activity + +[Term] +id: GO:0016986 +name: obsolete transcription initiation factor activity +namespace: molecular_function +def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "transcription initiation factor activity" EXACT [] +synonym: "transcriptional initiation factor activity" EXACT [] +is_obsolete: true +consider: GO:0140223 + +[Term] +id: GO:0016987 +name: sigma factor activity +namespace: molecular_function +alt_id: GO:0000996 +alt_id: GO:0001053 +def: "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins." [GOC:txnOH-2018] +synonym: "bacterial sigma factor activity" NARROW [] +synonym: "core DNA-dependent RNA polymerase binding promoter specificity activity" EXACT [] +synonym: "DNA-dependent RNA polymerase promoter selection factor" EXACT [] +synonym: "plastid sigma factor activity" NARROW [] +synonym: "promoter selection factor activity" NARROW [] +synonym: "sigma transcription factor" EXACT [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0016988 +name: obsolete transcription initiation factor antagonist activity +namespace: molecular_function +def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] +comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be. +synonym: "transcription initiation factor antagonist activity" EXACT [] +synonym: "transcriptional initiation factor antagonist activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0016989 +name: sigma factor antagonist activity +namespace: molecular_function +def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors] +synonym: "anti-sigma factor activity" EXACT [] +is_a: GO:0003714 ! transcription corepressor activity + +[Term] +id: GO:0016990 +name: arginine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] +synonym: "arginine dihydrolase activity" RELATED [EC:3.5.3.6] +synonym: "citrulline iminase activity" RELATED [EC:3.5.3.6] +synonym: "L-arginine deiminase activity" RELATED [EC:3.5.3.6] +synonym: "L-arginine iminohydrolase activity" RELATED [EC:3.5.3.6] +xref: EC:3.5.3.6 +xref: MetaCyc:ARGININE-DEIMINASE-RXN +xref: RHEA:19597 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0016992 +name: lipoate synthase activity +namespace: molecular_function +alt_id: GO:0017140 +def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109] +synonym: "LipA" RELATED [EC:2.8.1.8] +synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb] +synonym: "lipoyl synthase activity" RELATED [EC:2.8.1.8] +synonym: "LS" RELATED [EC:2.8.1.8] +synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.8] +synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" RELATED [EC:2.8.1.8] +xref: EC:2.8.1.8 +xref: MetaCyc:RXN0-949 +xref: Reactome:R-HSA-6793591 "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH" +xref: RHEA:16585 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0016993 +name: precorrin-8X methylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.99.61] +synonym: "HBA synthase activity" RELATED [EC:5.4.99.61] +synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.99.61] +synonym: "precorrin isomerase activity" RELATED [EC:5.4.99.61] +synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [] +xref: EC:5.4.99.61 +xref: MetaCyc:5.4.1.2-RXN +xref: RHEA:22512 +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0016994 +name: precorrin-6A reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] +synonym: "precorrin-6B:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.54] +synonym: "precorrin-6X reductase activity" EXACT [] +synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" RELATED [EC:1.3.1.54] +synonym: "precorrin-6Y:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.54] +xref: EC:1.3.1.54 +xref: MetaCyc:1.3.1.54-RXN +xref: RHEA:23408 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0016995 +name: cholesterol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2." [RHEA:32183] +synonym: "3beta-hydroxy steroid oxidoreductase activity" RELATED [EC:1.1.3.6] +synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" RELATED [EC:1.1.3.6] +synonym: "cholesterol- O2 oxidoreductase activity" RELATED [EC:1.1.3.6] +synonym: "cholesterol-O(2) oxidoreductase activity" RELATED [EC:1.1.3.6] +synonym: "cholesterol-O2 oxidoreductase activity" RELATED [EC:1.1.3.6] +synonym: "cholesterol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.6] +xref: EC:1.1.3.6 +xref: KEGG_REACTION:R01459 +xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN +xref: RHEA:32183 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0016996 +name: endo-alpha-(2,8)-sialidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] +synonym: "alpha-2,8-sialosylhydrolase activity" RELATED [EC:3.2.1.129] +synonym: "endo-N-acetylneuraminidase activity" RELATED [EC:3.2.1.129] +synonym: "endo-N-acylneuraminidase activity" RELATED [EC:3.2.1.129] +synonym: "endoneuraminidase activity" RELATED [EC:3.2.1.129] +synonym: "endosialidase activity" RELATED [EC:3.2.1.129] +synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" RELATED [EC:3.2.1.129] +synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" RELATED [EC:3.2.1.129] +synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" RELATED [EC:3.2.1.129] +xref: EC:3.2.1.129 +xref: MetaCyc:3.2.1.129-RXN +is_a: GO:0016997 ! alpha-sialidase activity + +[Term] +id: GO:0016997 +name: alpha-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0016998 +name: cell wall macromolecule catabolic process +namespace: biological_process +alt_id: GO:0044039 +def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] +synonym: "cell wall breakdown" RELATED [GOC:mah] +synonym: "cell wall catabolism" RELATED [GOC:mah] +synonym: "cell wall degradation" RELATED [GOC:mah] +synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah] +synonym: "cellular cell wall macromolecule catabolic process" EXACT [] +synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah] +synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah] +is_a: GO:0044036 ! cell wall macromolecule metabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0016999 +name: antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] +synonym: "antibiotic metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0017000 +name: antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] +subset: goslim_metagenomics +synonym: "antibiotic anabolism" EXACT [] +synonym: "antibiotic biosynthesis" EXACT [] +synonym: "antibiotic formation" EXACT [] +synonym: "antibiotic synthesis" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0017001 +name: antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] +synonym: "antibiotic breakdown" EXACT [] +synonym: "antibiotic catabolism" EXACT [] +synonym: "antibiotic degradation" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017002 +name: activin-activated receptor activity +namespace: molecular_function +def: "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "activin receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity + +[Term] +id: GO:0017003 +name: protein-heme linkage +namespace: biological_process +def: "The covalent linkage of heme and a protein." [GOC:ma] +synonym: "protein-haem linkage" EXACT [] +is_a: GO:0017006 ! protein-tetrapyrrole linkage + +[Term] +id: GO:0017004 +name: cytochrome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] +subset: goslim_metagenomics +synonym: "cytochrome biogenesis" BROAD [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0017005 +name: 3'-tyrosyl-DNA phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265] +comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. +is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity + +[Term] +id: GO:0017006 +name: protein-tetrapyrrole linkage +namespace: biological_process +def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0017007 +name: protein-bilin linkage +namespace: biological_process +def: "The covalent linkage of bilin and a protein." [GOC:ai] +is_a: GO:0017006 ! protein-tetrapyrrole linkage + +[Term] +id: GO:0017008 +name: protein-phycobiliviolin linkage +namespace: biological_process +def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258] +xref: RESID:AA0258 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017009 +name: protein-phycocyanobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131] +xref: RESID:AA0131 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017010 +name: protein-phycourobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260] +xref: RESID:AA0260 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017011 +name: protein-phycoerythrobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259] +xref: RESID:AA0132 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017012 +name: protein-phytochromobilin linkage +namespace: biological_process +def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133] +xref: RESID:AA0133 +is_a: GO:0017007 ! protein-bilin linkage + +[Term] +id: GO:0017013 +name: protein flavinylation +namespace: biological_process +def: "The addition of a flavin group to a protein amino acid." [GOC:ai] +synonym: "protein amino acid flavinylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0017014 +name: protein nitrosylation +namespace: biological_process +def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426] +synonym: "protein amino acid nitrosylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0017015 +name: regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] +synonym: "regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus +relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0017017 +name: MAP kinase tyrosine/serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] +synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] +is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity +is_a: GO:0033549 ! MAP kinase phosphatase activity + +[Term] +id: GO:0017018 +name: myosin phosphatase activity +namespace: molecular_function +alt_id: GO:0017019 +def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] +synonym: "myosin phosphatase myosin binding" RELATED [] +synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] +xref: Reactome:R-HSA-390593 "ATP Hydrolysis By Myosin" +xref: Reactome:R-HSA-445699 "ATP Hydrolysis By Myosin" +is_a: GO:0004722 ! protein serine/threonine phosphatase activity + +[Term] +id: GO:0017020 +name: myosin phosphatase regulator activity +namespace: molecular_function +def: "Binds to and modulates of the activity of myosin phosphatase." [GOC:ai, PMID:10491107] +synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0017021 +name: obsolete myosin phosphatase myosin binding +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function. +synonym: "myosin phosphatase myosin binding" EXACT [] +is_obsolete: true +consider: GO:0017018 +consider: GO:0017022 + +[Term] +id: GO:0017022 +name: myosin binding +namespace: molecular_function +def: "Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah] +synonym: "myosin phosphatase myosin binding" NARROW [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0017023 +name: myosin phosphatase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. Composed of a PP1 catalytic subunit (PP1c/PPP1CB) and a myosin phosphatase targeting subunit (MYPT1/PPP1R12A)." [PMID:30076859] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex + +[Term] +id: GO:0017024 +name: myosin I binding +namespace: molecular_function +def: "Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0017025 +name: TBP-class protein binding +namespace: molecular_function +def: "Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867] +synonym: "TATA-binding protein binding" NARROW [] +synonym: "TBP binding" NARROW [] +synonym: "TBP-related factor (TRF) protein binding" NARROW [] +is_a: GO:0140296 ! general transcription initiation factor binding + +[Term] +id: GO:0017026 +name: obsolete procollagen C-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "BMP1" NARROW [] +synonym: "carboxyprocollagen peptidase activity" RELATED [] +synonym: "procollagen C-endopeptidase activity" EXACT [] +synonym: "procollagen C-proteinase activity" RELATED [] +synonym: "procollagen C-terminal peptidase activity" RELATED [] +synonym: "procollagen C-terminal proteinase activity" RELATED [] +synonym: "procollagen carboxy-terminal proteinase activity" RELATED [] +synonym: "procollagen carboxypeptidase activity" RELATED [] +synonym: "procollagen peptidase activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0017027 +name: obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "transmembrane receptor protein serine/threonine kinase receptor-associated protein activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0017028 +name: obsolete protein stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid] +comment: This term was made obsolete because it represents a biological process. +synonym: "protein stabilization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0050821 + +[Term] +id: GO:0017029 +name: obsolete lysosomal protein stabilization +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it contains both component and function information. +synonym: "lysosomal protein stabilization" EXACT [] +is_obsolete: true +consider: GO:0005764 +consider: GO:0050821 + +[Term] +id: GO:0017030 +name: obsolete beta-galactosidase stabilization activity +namespace: molecular_function +def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai] +comment: This term was made obsolete because it represents a biological process. +synonym: "beta-galactosidase stabilization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0050821 + +[Term] +id: GO:0017032 +name: amino acid:potassium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] +synonym: "potassium:amino acid symporter activity" EXACT [] +is_a: GO:0005416 ! amino acid:cation symporter activity +is_a: GO:0015079 ! potassium ion transmembrane transporter activity + +[Term] +id: GO:0017038 +name: protein import +namespace: biological_process +def: "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] +synonym: "protein uptake" EXACT [] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0017039 +name: obsolete dipeptidyl-peptidase III activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] +comment: This term was made obsolete because it represents a gene product. +synonym: "dipeptidyl aminopeptidase III activity" RELATED [EC:3.4.14.4] +synonym: "dipeptidyl arylamidase III activity" RELATED [EC:3.4.14.4] +synonym: "dipeptidyl-peptidase III activity" EXACT [] +synonym: "DPP III activity" RELATED [EC:3.4.14.4] +synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] +synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] +is_obsolete: true +replaced_by: GO:0008239 + +[Term] +id: GO:0017040 +name: N-acylsphingosine amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] +synonym: "acylsphingosine deacylase activity" RELATED [EC:3.5.1.23] +synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] +xref: EC:3.5.1.23 +xref: MetaCyc:CERAMIDASE-RXN +xref: Reactome:R-HSA-1606583 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)" +xref: Reactome:R-HSA-1606602 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)" +xref: Reactome:R-HSA-428205 "ceramide + H2O => stearate + sphingosine [Golgi]" +xref: Reactome:R-HSA-428231 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]" +xref: RHEA:20856 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017041 +name: galactosylgalactosylglucosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] +synonym: "ceramide trihexosidase activity" RELATED [EC:3.2.1.47] +synonym: "ceramidetrihexosidase activity" RELATED [EC:3.2.1.47] +synonym: "ceramidetrihexoside alpha-galactosidase activity" RELATED [EC:3.2.1.47] +synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" RELATED [EC:3.2.1.47] +synonym: "trihexosyl ceramide galactosidase activity" RELATED [EC:3.2.1.47] +synonym: "trihexosylceramide alpha-galactosidase activity" RELATED [EC:3.2.1.47] +xref: EC:3.2.1.47 +xref: MetaCyc:3.2.1.47-RXN +xref: RHEA:21112 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0017042 +name: glycosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [PMID:10692580, PMID:9762914] +synonym: "cerebrosidase activity" RELATED [EC:3.2.1.62] +synonym: "glycosyl ceramide glycosylhydrolase activity" RELATED [EC:3.2.1.62] +synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" RELATED [EC:3.2.1.62] +xref: EC:3.2.1.62 +xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0017043 +name: obsolete adrenocorticotropin +namespace: molecular_function +def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "adrenocorticotropin" EXACT [] +synonym: "corticotropin" BROAD [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0046886 +consider: GO:0046887 + +[Term] +id: GO:0017044 +name: melanocyte-stimulating hormone activity +namespace: molecular_function +def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732] +synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732] +synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732] +synonym: "melanocyte stimulating hormone activity" EXACT [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0017045 +name: corticotropin-releasing hormone activity +namespace: molecular_function +def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732] +synonym: "adrenocorticotropin-releasing hormone" EXACT [] +xref: Wikipedia:Corticotropin-releasing_hormone +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0017046 +name: peptide hormone binding +namespace: molecular_function +def: "Binding to a peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732] +synonym: "polypeptide hormone binding" EXACT [] +is_a: GO:0042277 ! peptide binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0017050 +name: D-erythro-sphingosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] +synonym: "sphingosine kinase activity" EXACT [] +xref: MetaCyc:RXN3DJ-11417 +xref: Reactome:R-HSA-428273 "SPHK1 phosphorylates SPG to S1P" +xref: Reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate" +xref: Reactome:R-HSA-9625814 "SPHK1 phosphorylates sphingosine in response to E2 stimulation" +xref: Reactome:R-HSA-9695949 "SPHK2 phosphorylates SPG to S1P" +xref: RHEA:35847 +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0017051 +name: retinol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0017052 +name: obsolete insulin-like growth factor binding protein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "insulin-like growth factor binding protein" EXACT [] +is_obsolete: true +consider: GO:0016942 + +[Term] +id: GO:0017053 +name: transcription repressor complex +namespace: cellular_component +alt_id: GO:0090568 +alt_id: GO:0090569 +def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] +subset: goslim_pir +synonym: "cytoplasmic transcriptional repressor complex" RELATED [] +synonym: "nuclear transcriptional repressor complex" RELATED [] +synonym: "transcription factor inhibitor complex" EXACT [GOC:bhm] +synonym: "transcriptional repressor complex" EXACT [] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0017054 +name: negative cofactor 2 complex +namespace: cellular_component +def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0017055 +name: negative regulation of RNA polymerase II transcription preinitiation complex assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] +synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] +synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0045898 ! regulation of RNA polymerase II transcription preinitiation complex assembly +is_a: GO:0060633 ! negative regulation of transcription initiation from RNA polymerase II promoter +relationship: negatively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly + +[Term] +id: GO:0017056 +name: structural constituent of nuclear pore +namespace: molecular_function +alt_id: GO:0005487 +def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992] +comment: Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively. +synonym: "nuclear pore activity" RELATED [] +synonym: "nucleocytoplasmic transporter activity" EXACT [] +xref: Reactome:R-HSA-1176059 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus" +xref: Reactome:R-HSA-170796 "NPC transports GCK1:GKRP from cytosol to nucleoplasm" +xref: Reactome:R-HSA-192627 "Viral mRNA Export" +xref: Reactome:R-HSA-192925 "Export of Spliced Viral mRNA" +xref: Reactome:R-HSA-5252041 "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm" +xref: Reactome:R-HSA-5578744 "Importin-8 imports AGO2:miRNA into the nucleus" +xref: Reactome:R-HSA-5661474 "Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm" +xref: Reactome:R-HSA-6783483 "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol" +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0017057 +name: 6-phosphogluconolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12556] +synonym: "6-PGL" RELATED [EC:3.1.1.31] +synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" RELATED [EC:3.1.1.31] +synonym: "phosphogluconolactonase activity" RELATED [EC:3.1.1.31] +xref: EC:3.1.1.31 +xref: KEGG_REACTION:R02035 +xref: MetaCyc:6PGLUCONOLACT-RXN +xref: Reactome:R-HSA-71296 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate" +xref: RHEA:12556 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0017058 +name: FH1 domain binding +namespace: molecular_function +def: "Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0017059 +name: serine C-palmitoyltransferase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] +is_a: GO:0031211 ! endoplasmic reticulum palmitoyltransferase complex + +[Term] +id: GO:0017060 +name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] +synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "alpha(1,4)-L-fucosyltransferase activity" BROAD [] +synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" BROAD [EC:2.4.1.65] +synonym: "alpha-(1,4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "alpha-(1->4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "alpha-4-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "blood group Lewis alpha-4-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "blood-group substance Lea-dependent fucosyltransferase" BROAD [EC:2.4.1.65] +synonym: "fuca(1,3)-glycosidic linkage formation" RELATED [] +synonym: "FucT-II activity" BROAD [EC:2.4.1.65] +synonym: "galactoside 3(4)-L-fucosyltransferase activity" BROAD [] +synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.65] +synonym: "Lewis alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "Lewis blood group alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] +synonym: "Lewis FT activity" BROAD [EC:2.4.1.65] +synonym: "Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity" BROAD [] +synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] +xref: EC:2.4.1.65 +xref: MetaCyc:2.4.1.65-RXN +xref: Reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc" +xref: Reactome:R-HSA-9603986 "FUT3 transfers Fuc to Type 1 chains to form LeA" +xref: RHEA:23628 +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0017061 +name: S-methyl-5-thioadenosine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] +synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] +synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" RELATED [EC:2.4.2.28] +synonym: "MeSAdo phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "MeSAdo/Ado phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "methylthioadenosine nucleoside phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "methylthioadenosine phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "MTA phosphorylase activity" RELATED [EC:2.4.2.28] +synonym: "MTAPase activity" RELATED [EC:2.4.2.28] +synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" RELATED [EC:2.4.2.28] +xref: EC:2.4.2.28 +xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN +xref: Reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated" +xref: RHEA:11852 +is_a: GO:0004731 ! purine-nucleoside phosphorylase activity + +[Term] +id: GO:0017062 +name: respiratory chain complex III assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/] +synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT [] +synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT [] +synonym: "complex III assembly" EXACT [] +synonym: "complex III biogenesis" EXACT [] +synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc] +synonym: "cytochrome bc(1) complex biogenesis" EXACT [] +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0017063 +name: obsolete phosphatidylserine-specific phospholipase A1 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] +comment: This term was made obsolete because the definition does not match the term name. +synonym: "phosphatidylserine-specific phospholipase A1 activity" EXACT [] +is_obsolete: true +consider: GO:0052739 +consider: GO:0052740 + +[Term] +id: GO:0017064 +name: fatty acid amide hydrolase activity +namespace: molecular_function +alt_id: GO:0017073 +def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893] +xref: Reactome:R-HSA-5693742 "FAAH hydrolyses AEA to AA and ETA" +xref: Reactome:R-HSA-5693751 "FAAH2 hydrolyses AEA to AA and ETA" +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017065 +name: single-strand selective uracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] +synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] +xref: Reactome:R-HSA-110221 "Cleavage of uracil by SMUG1 glycosylase" +is_a: GO:0004844 ! uracil DNA N-glycosylase activity + +[Term] +id: GO:0017067 +name: tyrosine-ester sulfotransferase activity +namespace: molecular_function +alt_id: GO:0008128 +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19977] +synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" RELATED [EC:2.8.2.9] +synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] +synonym: "L-tyrosine methyl ester sulfotransferase activity" RELATED [EC:2.8.2.9] +synonym: "tyrosine-ester sulphotransferase activity" EXACT [] +xref: EC:2.8.2.9 +xref: KEGG_REACTION:R04213 +xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN +xref: RHEA:19977 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0017069 +name: snRNA binding +namespace: molecular_function +alt_id: GO:0000945 +def: "Binding to a small nuclear RNA (snRNA)." [GOC:mah] +synonym: "base pairing with snRNA" NARROW [] +synonym: "small nuclear RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0017070 +name: U6 snRNA binding +namespace: molecular_function +def: "Binding to a U6 small nuclear RNA (U6 snRNA)." [GOC:mah] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0017071 +name: intracellular cyclic nucleotide activated cation channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0017072 +name: obsolete tubulin-specific chaperone activity +namespace: molecular_function +def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227] +comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. +synonym: "tubulin-specific chaperone activity" EXACT [] +is_obsolete: true +consider: GO:0007021 + +[Term] +id: GO:0017074 +name: obsolete procollagen N-endopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminoprocollagen peptidase activity" RELATED [] +synonym: "aminoterminal procollagen peptidase activity" RELATED [] +synonym: "procollagen aminopeptidase activity" RELATED [] +synonym: "procollagen aminoterminal protease activity" RELATED [] +synonym: "procollagen N-endopeptidase activity" EXACT [] +synonym: "procollagen N-proteinase activity" RELATED [] +synonym: "procollagen N-terminal peptidase activity" RELATED [] +synonym: "procollagen N-terminal proteinase activity" RELATED [] +synonym: "type I/II procollagen N-proteinase activity" RELATED [] +synonym: "type III procollagen" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0017075 +name: syntaxin-1 binding +namespace: molecular_function +def: "Binding to a syntaxin-1 SNAP receptor." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0017076 +name: purine nucleotide binding +namespace: molecular_function +def: "Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0017077 +name: oxidative phosphorylation uncoupler activity +namespace: molecular_function +alt_id: GO:0015302 +def: "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] +synonym: "mitochondrial uncoupling protein activity" NARROW [] +synonym: "uncoupling protein activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0017078 +name: obsolete Hsc70 protein regulator activity +namespace: molecular_function +def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'. +synonym: "Hsc70 interacting protein" BROAD [] +synonym: "Hsc70 protein regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0031072 +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0017080 +name: sodium channel regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a sodium channel." [GOC:mah] +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0017081 +name: chloride channel regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a chloride channel." [GOC:mah] +xref: Reactome:R-HSA-383190 "HCO3- transport through ion channel" +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0017082 +name: obsolete mineralocorticoid receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by binding to a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876] +synonym: "aldosterone receptor" NARROW [] +is_obsolete: true + +[Term] +id: GO:0017083 +name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152, RHEA:14257] +synonym: "galactoside 3-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] +synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.152] +synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] +synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] +xref: EC:2.4.1.152 +xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN +xref: RHEA:14257 +is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity + +[Term] +id: GO:0017084 +name: delta1-pyrroline-5-carboxylate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] +synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] +xref: Reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]" +xref: RHEA:33207 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0017085 +name: response to insecticide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] +synonym: "insecticide resistance" RELATED [] +synonym: "insecticide susceptibility/resistance" RELATED [] +is_a: GO:0009636 ! response to toxic substance + +[Term] +id: GO:0017086 +name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex +namespace: cellular_component +alt_id: GO:0031212 +def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] +synonym: "BCADH" EXACT [] +synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0017087 +name: mitochondrial processing peptidase complex +namespace: cellular_component +def: "A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [GOC:mah] +comment: Note that monomeric mitochondrial processing peptidases have been observed. +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0017088 +name: obsolete X-Pro dipeptidyl-peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] +comment: This term was made obsolete because it represents a gene product. +synonym: "PepX" RELATED [EC:3.4.14.11] +synonym: "X-Pro dipeptidyl-peptidase activity" EXACT [] +synonym: "X-prolyl dipeptidyl aminopeptidase activity" RELATED [EC:3.4.14.11] +synonym: "X-prolyl dipeptidyl peptidase activity" RELATED [EC:3.4.14.11] +synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008239 + +[Term] +id: GO:0017089 +name: glycolipid transfer activity +namespace: molecular_function +def: "Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid." [PMID:30337668] +synonym: "glycolipid carrier activity" EXACT [] +synonym: "glycolipid transporter activity" BROAD [] +synonym: "intermembrane glycolipid transfer activity" NARROW [] +synonym: "intermembrane glycolipid transporter activity" NARROW [] +xref: Reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane" +xref: Reactome:R-HSA-9697077 "Rv1410c transports lprG:LM,LAM from cytosol to the cell wall" +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0017090 +name: meprin A complex +namespace: cellular_component +def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [GOC:mah, MEROPS_fam:M12] +synonym: "PABA peptide hydrolase complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016021 ! integral component of membrane + +[Term] +id: GO:0017092 +name: obsolete sterol regulatory element-binding protein site 2 protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP site 2 protease activity" EXACT [] +synonym: "sterol regulatory element-binding protein site 2 protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008237 + +[Term] +id: GO:0017093 +name: obsolete sterol regulatory element-binding protein protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP protease activity" EXACT [] +synonym: "sterol regulatory element-binding protein protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008233 + +[Term] +id: GO:0017094 +name: obsolete sterol regulatory element-binding protein site 1 protease activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] +comment: This term was made obsolete because it represents a gene product. +synonym: "SREBP site 1 protease activity" EXACT [] +synonym: "sterol regulatory element-binding protein site 1 protease activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008236 + +[Term] +id: GO:0017095 +name: heparan sulfate 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] +synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] +synonym: "heparin 6-O-sulfotransferase activity" RELATED [] +xref: EC:2.8.2.- +xref: Reactome:R-HSA-2076419 "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin" +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0017096 +name: acetylserotonin O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0017097 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4] +synonym: "acetylserotonin methyltransferase activity" RELATED [EC:2.1.1.4] +synonym: "hydroxyindole methyltransferase activity" RELATED [EC:2.1.1.4] +synonym: "hydroxyindole O-methyltransferase activity" RELATED [EC:2.1.1.4] +synonym: "N-acetylserotonin O-methyltransferase activity" RELATED [EC:2.1.1.4] +synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" RELATED [EC:2.1.1.4] +xref: EC:2.1.1.4 +xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN +xref: RHEA:15573 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0017098 +name: sulfonylurea receptor binding +namespace: molecular_function +def: "Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] +synonym: "sulfonylurea receptor ligand" NARROW [] +synonym: "sulphonylurea receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0017099 +name: very-long-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:mah] +synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT [] +xref: Reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA" +is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity + +[Term] +id: GO:0017101 +name: aminoacyl-tRNA synthetase multienzyme complex +namespace: cellular_component +def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] +synonym: "aminoacyl-tRNA synthetase complex" EXACT [] +synonym: "multisynthetase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0017102 +name: methionyl glutamyl tRNA synthetase complex +namespace: cellular_component +def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0017103 +name: UTP:galactose-1-phosphate uridylyltransferase activity +namespace: molecular_function +alt_id: GO:0003982 +def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14209] +synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10] +synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] +synonym: "galactose 1-phosphate uridyltransferase activity" RELATED [EC:2.7.7.10] +synonym: "galactose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10] +synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] +synonym: "UDPgalactose pyrophosphorylase activity" RELATED [EC:2.7.7.10] +synonym: "uridine diphosphate galactose pyrophosphorylase activity" RELATED [EC:2.7.7.10] +synonym: "uridine diphosphogalactose pyrophosphorylase activity" RELATED [EC:2.7.7.10] +synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10] +synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.10] +synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] +xref: EC:2.7.7.10 +xref: KEGG_REACTION:R00502 +xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN +xref: RHEA:14209 +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0017105 +name: acyl-CoA delta11-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O. The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs." [EC:1.14.19.5] +synonym: "acyl-CoA D11-desaturase activity" EXACT [] +synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] +xref: EC:1.14.19.5 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0017106 +name: obsolete activin inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] +comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'. +synonym: "activin inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0098772 + +[Term] +id: GO:0017107 +name: obsolete anion exchanger adaptor activity +namespace: molecular_function +def: "OBSOLETE. The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] +comment: The term was made obsolete because it referred to an interaction of an anion transporter with the AP1 adaptor by which it is probably transported, see: PMID:22744004; PMID:20833140; ie the adaptor does not specifically target an anion adaptor. +is_obsolete: true + +[Term] +id: GO:0017108 +name: 5'-flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] +synonym: "5' flap endonuclease activity" EXACT [] +xref: Reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" +xref: Reactome:R-HSA-174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" +xref: Reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" +xref: Reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" +xref: Reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" +xref: Reactome:R-HSA-69152 "Removal of remaining Flap" +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters +is_a: GO:0048256 ! flap endonuclease activity + +[Term] +id: GO:0017109 +name: glutamate-cysteine ligase complex +namespace: cellular_component +def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] +synonym: "gamma-glutamylcysteine synthetase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0017110 +name: nucleoside-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate." [EC:3.6.1.6] +synonym: "apyrase activity" BROAD [] +synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] +synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] +synonym: "NDPase activity" RELATED [EC:3.6.1.6] +synonym: "nucleoside 5'-diphosphatase activity" RELATED [EC:3.6.1.6] +synonym: "nucleoside diphosphatase activity" EXACT [] +synonym: "nucleoside diphosphate phosphatase activity" RELATED [EC:3.6.1.6] +synonym: "nucleoside diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.6] +synonym: "nucleoside-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.6] +synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] +synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] +xref: EC:3.6.1.6 +xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN +xref: Reactome:R-HSA-2395876 "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP" +xref: Reactome:R-HSA-8850854 "NTPDase1 hydrolyzes nucleoside diphosphates" +xref: Reactome:R-HSA-8851129 "NTPDase3 hydrolyzes nucleoside diphosphates" +xref: Reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates" +xref: Reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates" +xref: Reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates" +xref: Reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates" +xref: RHEA:36799 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0017111 +name: nucleoside-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [RHEA:23680] +subset: goslim_chembl +subset: goslim_metagenomics +synonym: "apyrase activity" BROAD [] +synonym: "NTPase activity" RELATED [] +synonym: "nucleoside 5-triphosphatase activity" RELATED [] +synonym: "nucleoside triphosphatase activity" EXACT [] +synonym: "nucleoside triphosphate hydrolase activity" RELATED [] +synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] +synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] +synonym: "unspecific diphosphate phosphohydrolase activity" RELATED [] +xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN +xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" +xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" +xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" +xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" +xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" +xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" +xref: RHEA:23680 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0017113 +name: dihydropyrimidine dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] +synonym: "4,5-dihydrothymine: oxidoreductase activity" RELATED [EC:1.3.1.2] +synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" RELATED [EC:1.3.1.2] +synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.2] +synonym: "DHPDH" RELATED [EC:1.3.1.2] +synonym: "DHU dehydrogenase activity" RELATED [EC:1.3.1.2] +synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] +synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] +synonym: "dihydrouracil dehydrogenase (NADP)" RELATED [EC:1.3.1.2] +synonym: "dihydrouracil dehydrogenase (NADP+) activity" RELATED [EC:1.3.1.2] +synonym: "DPD" RELATED [EC:1.3.1.2] +synonym: "hydropyrimidine dehydrogenase activity" RELATED [EC:1.3.1.2] +xref: EC:1.3.1.2 +xref: MetaCyc:1.3.1.2-RXN +xref: Reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+" +xref: Reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+" +xref: RHEA:18093 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0017114 +name: obsolete wide-spectrum protease inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it represents a regulator of non-existent molecular function. +synonym: "wide-spectrum protease inhibitor activity" EXACT [] +synonym: "wide-spectrum proteinase inhibitor" EXACT [] +is_obsolete: true +replaced_by: GO:0030414 + +[Term] +id: GO:0017116 +name: single-stranded DNA helicase activity +namespace: molecular_function +alt_id: GO:0043142 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [GOC:jl] +synonym: "single-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT [] +synonym: "single-stranded DNA-dependent ATPase activity" EXACT [] +synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah] +synonym: "ssDNA-dependent ATPase activity" EXACT [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0017117 +name: single-stranded DNA-dependent ATP-dependent DNA helicase complex +namespace: cellular_component +def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] +synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah] +is_a: GO:0033202 ! DNA helicase complex + +[Term] +id: GO:0017118 +name: lipoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005, RHEA:20473] +xref: RHEA:20473 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0017119 +name: Golgi transport complex +namespace: cellular_component +def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665] +synonym: "COG complex" EXACT [] +synonym: "conserved oligomeric Golgi complex" EXACT [] +synonym: "Sec34/35 complex" NARROW [] +is_a: GO:0099023 ! vesicle tethering complex +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0017120 +name: obsolete polyphosphatidylinositol phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] +comment: This term was made obsolete because it represents a gene product. +synonym: "polyphosphatidylinositol phosphatase activity" EXACT [] +synonym: "polyphosphoinositide phosphatase activity" EXACT [] +is_obsolete: true +consider: GO:0004438 +consider: GO:0034593 +consider: GO:0043812 + +[Term] +id: GO:0017121 +name: plasma membrane phospholipid scrambling +namespace: biological_process +def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864] +comment: Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'. +synonym: "phospholipid scrambling" RELATED [] +synonym: "PL scrambling" EXACT [] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0045332 ! phospholipid translocation + +[Term] +id: GO:0017122 +name: protein N-acetylglucosaminyltransferase complex +namespace: cellular_component +def: "A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits." [PMID:15247246] +synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah] +synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0017124 +name: SH3 domain binding +namespace: molecular_function +def: "Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0017125 +name: deoxycytidyl transferase activity +namespace: molecular_function +alt_id: GO:0019986 +def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] +synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] +xref: Reactome:R-HSA-110308 "REV1 inserts dCMP opposite to AP sites in DNA" +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0017126 +name: nucleologenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] +synonym: "nucleolus assembly" NARROW [GOC:mah] +synonym: "nucleolus biogenesis" EXACT [] +is_a: GO:0007000 ! nucleolus organization +is_a: GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0017128 +name: phospholipid scramblase activity +namespace: molecular_function +def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864] +comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0140303 ! intramembrane lipid transporter activity + +[Term] +id: GO:0017129 +name: triglyceride binding +namespace: molecular_function +def: "Binding to a triester of glycerol." [GOC:jl, ISBN:0198506732] +synonym: "triacylglycerol binding" EXACT [GOC:mah] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0017130 +name: poly(C) RNA binding +namespace: molecular_function +def: "Binding to a sequence of cytosine residues in an RNA molecule." [GOC:mah] +synonym: "poly(C) binding" BROAD [GOC:mah] +synonym: "poly(rC) binding" EXACT [GOC:mah] +is_a: GO:0008187 ! poly-pyrimidine tract binding + +[Term] +id: GO:0017131 +name: uridine-rich cytoplasmic polyadenylylation element binding +namespace: molecular_function +def: "Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828] +synonym: "U-rich CPE binding" EXACT [PMID:7954828] +synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] +is_a: GO:0008187 ! poly-pyrimidine tract binding + +[Term] +id: GO:0017133 +name: mitochondrial electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732] +is_a: GO:0045251 ! electron transfer flavoprotein complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0017134 +name: fibroblast growth factor binding +namespace: molecular_function +alt_id: GO:0048602 +alt_id: GO:0048603 +alt_id: GO:0048604 +alt_id: GO:0048605 +alt_id: GO:0048606 +alt_id: GO:0048607 +def: "Binding to a fibroblast growth factor." [PMID:9806903] +synonym: "FGF 1 binding" NARROW [] +synonym: "FGF 2 binding" NARROW [] +synonym: "FGF 3 binding" NARROW [] +synonym: "FGF 4 binding" NARROW [] +synonym: "FGF 5 binding" NARROW [] +synonym: "FGF 6 binding" NARROW [] +synonym: "FGF binding" EXACT [] +synonym: "fibroblast growth factor 1 binding" NARROW [] +synonym: "fibroblast growth factor 2 binding" NARROW [] +synonym: "fibroblast growth factor 3 binding" NARROW [] +synonym: "fibroblast growth factor 4 binding" NARROW [] +synonym: "fibroblast growth factor 5 binding" NARROW [] +synonym: "fibroblast growth factor 6 binding" NARROW [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0017135 +name: obsolete membrane-associated protein with guanylate kinase activity interacting +namespace: molecular_function +def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005] +comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense. +synonym: "membrane-associated protein with guanylate kinase activity interacting" EXACT [] +is_obsolete: true +consider: GO:0019899 + +[Term] +id: GO:0017136 +name: NAD-dependent histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737] +synonym: "SIR2" RELATED [] +is_a: GO:0004407 ! histone deacetylase activity +is_a: GO:0034979 ! NAD-dependent protein deacetylase activity + +[Term] +id: GO:0017139 +name: obsolete arsenate sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "arsenate sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046685 + +[Term] +id: GO:0017141 +name: obsolete antibiotic susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "antibiotic susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046677 + +[Term] +id: GO:0017142 +name: obsolete toxin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "toxin susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0009636 + +[Term] +id: GO:0017143 +name: insecticide metabolic process +namespace: biological_process +alt_id: GO:0017138 +def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] +synonym: "insecticide metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0009404 ! toxin metabolic process +relationship: part_of GO:0017085 ! response to insecticide + +[Term] +id: GO:0017145 +name: stem cell division +namespace: biological_process +def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] +synonym: "stem cell renewal" EXACT [] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0017146 +name: NMDA selective glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] +synonym: "N-methyl-D-aspartate selective glutamate receptor complex" EXACT [] +synonym: "NMDA-selective glutamate receptor" EXACT [] +is_a: GO:0008328 ! ionotropic glutamate receptor complex +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0017147 +name: Wnt-protein binding +namespace: molecular_function +def: "Binding to a Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] +subset: goslim_chembl +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0017148 +name: negative regulation of translation +namespace: biological_process +alt_id: GO:0016478 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] +synonym: "down regulation of protein biosynthetic process" EXACT [] +synonym: "down-regulation of protein biosynthetic process" EXACT [] +synonym: "downregulation of protein biosynthetic process" EXACT [] +synonym: "inhibition of protein biosynthetic process" NARROW [] +synonym: "negative regulation of protein anabolism" EXACT [] +synonym: "negative regulation of protein biosynthesis" EXACT [] +synonym: "negative regulation of protein biosynthetic process" EXACT [] +synonym: "negative regulation of protein formation" EXACT [] +synonym: "negative regulation of protein synthesis" EXACT [] +synonym: "protein biosynthesis inhibitor activity" RELATED [] +synonym: "protein biosynthetic process inhibitor activity" RELATED [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0006412 ! translation + +[Term] +id: GO:0017149 +name: obsolete protein biosynthetic process inhibitor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents involvement in a biological process. +synonym: "protein anabolism inhibitor activity" EXACT [] +synonym: "protein biosynthetic process inhibitor activity" EXACT [] +synonym: "protein formation inhibitor activity" EXACT [] +synonym: "protein synthesis inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0017148 + +[Term] +id: GO:0017150 +name: tRNA dihydrouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] +xref: MetaCyc:RXN0-1281 +xref: Reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs" +xref: RHEA:23624 +is_a: GO:0106413 ! dihydrouridine synthase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0017151 +name: DEAD/H-box RNA helicase binding +namespace: molecular_function +def: "Binding to a DEAD/H-box RNA helicase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0017153 +name: sodium:dicarboxylate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] +synonym: "sodium:dicarboxylate cotransporter activity" BROAD [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0005343 ! organic acid:sodium symporter activity + +[Term] +id: GO:0017154 +name: semaphorin receptor activity +namespace: molecular_function +def: "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0017155 +name: obsolete sodium:hydrogen antiporter regulator activity +namespace: molecular_function +alt_id: GO:0030040 +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because it represents a biological process. +synonym: "sodium:hydrogen antiporter regulator activity" EXACT [] +synonym: "sodium:proton antiporter regulator" EXACT [] +is_obsolete: true + +[Term] +id: GO:0017156 +name: calcium-ion regulated exocytosis +namespace: biological_process +def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators] +comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway. +synonym: "calcium ion-dependent exocytosis" EXACT [] +is_a: GO:0045055 ! regulated exocytosis + +[Term] +id: GO:0017157 +name: regulation of exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0017158 +name: regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +is_a: GO:1903305 ! regulation of regulated secretory pathway +relationship: regulates GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:0017159 +name: pantetheine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13445] +synonym: "(R)-pantetheine amidohydrolase activity" RELATED [EC:3.5.1.92] +synonym: "pantetheinase activity" RELATED [EC:3.5.1.92] +synonym: "vanin" RELATED [EC:3.5.1.92] +synonym: "vanin-1" RELATED [EC:3.5.1.92] +xref: EC:3.5.1.92 +xref: KEGG_REACTION:R02973 +xref: MetaCyc:3.5.1.92-RXN +xref: Reactome:R-HSA-8938300 "Vanin hydrolyses pantetheine to PanK, 2AET" +xref: RHEA:13445 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0017161 +name: inositol-1,3,4-trisphosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol" +xref: RHEA:43392 +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0017162 +name: aryl hydrocarbon receptor binding +namespace: molecular_function +def: "Binding to an aryl hydrocarbon receptor." [GOC:ai] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0017163 +name: obsolete basal transcription repressor activity +namespace: molecular_function +def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html] +comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "basal transcription repressor activity" EXACT [] +is_obsolete: true +consider: GO:0001217 +consider: GO:0001227 +consider: GO:0045892 + +[Term] +id: GO:0017164 +name: obsolete nicotinic acetylcholine receptor-associated protein activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product and not a molecular function. +synonym: "nicotinic acetylcholine receptor-associated protein activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0005515 + +[Term] +id: GO:0017165 +name: obsolete dipeptidase E activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-aspartyl dipeptidase activity" EXACT [] +synonym: "aspartyl dipeptidase activity" RELATED [EC:3.4.13.21] +synonym: "dipeptidase E activity" EXACT [] +synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] +synonym: "peptidase E activity" BROAD [EC:3.4.13.21] +is_obsolete: true +replaced_by: GO:0016805 + +[Term] +id: GO:0017166 +name: vinculin binding +namespace: molecular_function +def: "Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0017168 +name: 5-oxoprolinase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10348] +synonym: "5-OPase activity" RELATED [EC:3.5.2.9] +synonym: "5-oxo-L-prolinase activity" RELATED [EC:3.5.2.9] +synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" RELATED [EC:3.5.2.9] +synonym: "5-oxoprolinase (ATP-hydrolysing)" RELATED [EC:3.5.2.9] +synonym: "5-oxoprolinase activity" RELATED [EC:3.5.2.9] +synonym: "L-pyroglutamate hydrolase activity" RELATED [EC:3.5.2.9] +synonym: "oxoprolinase activity" RELATED [EC:3.5.2.9] +synonym: "pyroglutamase (ATP-hydrolysing)" RELATED [EC:3.5.2.9] +synonym: "pyroglutamase (ATP-hydrolyzing) activity" RELATED [EC:3.5.2.9] +synonym: "pyroglutamase activity" RELATED [EC:3.5.2.9] +synonym: "pyroglutamate hydrolase activity" RELATED [EC:3.5.2.9] +synonym: "pyroglutamic hydrolase activity" RELATED [EC:3.5.2.9] +xref: EC:3.5.2.9 +xref: KEGG_REACTION:R00251 +xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN +xref: Reactome:R-HSA-1247935 "OPLAH hydrolyses OPRO to L-Glu" +xref: Reactome:R-HSA-5603208 "Defective OPLAH does not hydrolyse OPRO" +xref: RHEA:10348 +xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing) +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0017169 +name: CDP-alcohol phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0017170 +name: obsolete KU70 binding +namespace: molecular_function +def: "OBSOLETE. Binding to Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "KU70 binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0017171 +name: serine hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0017172 +name: cysteine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20441] +xref: EC:1.13.11.20 +xref: KEGG_REACTION:R00893 +xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN +xref: Reactome:R-HSA-1614645 "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine" +xref: RHEA:20441 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0017174 +name: glycine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] +synonym: "glycine methyltransferase activity" RELATED [EC:2.1.1.20] +synonym: "GNMT" RELATED [EC:2.1.1.20] +synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" RELATED [EC:2.1.1.20] +synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" RELATED [EC:2.1.1.20] +xref: EC:2.1.1.156 +xref: EC:2.1.1.162 +xref: EC:2.1.1.20 +xref: KEGG_REACTION:R00367 +xref: MetaCyc:2.1.1.162-RXN +xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-6798317 "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC" +xref: RHEA:19937 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0017175 +name: obsolete IMP-GMP specific 5'-nucleotidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc] +comment: This term was made obsolete because it represents a gene product with two different activities. +synonym: "IMP-GMP specific 5'-nucleotidase activity" EXACT [] +is_obsolete: true +consider: GO:0050484 + +[Term] +id: GO:0017176 +name: phosphatidylinositol N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] +synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" RELATED [EC:2.4.1.198] +synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198] +synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198] +synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.198] +xref: EC:2.4.1.198 +xref: MetaCyc:2.4.1.198-RXN +xref: RHEA:14789 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0017177 +name: glucosidase II complex +namespace: cellular_component +def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] +comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. +synonym: "alpha-glucosidase II complex" RELATED [GOC:19605557, GOC:vw] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0017178 +name: diphthine-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate." [EC:6.3.1.14, RHEA:19753] +synonym: "diphthamide synthase activity" RELATED [EC:6.3.1.14] +synonym: "diphthamide synthetase activity" RELATED [EC:6.3.1.14] +synonym: "diphthine:ammonia ligase (ADP-forming)" RELATED [EC:6.3.1.14] +xref: EC:6.3.1.14 +xref: KEGG_REACTION:R03613 +xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN +xref: Reactome:R-HSA-5358475 "DPH6 ligates ammonium to diphthine-EEF2" +xref: RHEA:19753 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0017179 +name: peptidyl-diphthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] +synonym: "peptidyl-diphthine metabolism" EXACT [] +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0017180 +name: peptidyl-diphthine biosynthetic process from peptidyl-histidine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators] +synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT [] +is_a: GO:0017179 ! peptidyl-diphthine metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0017181 +name: peptidyl-diphthine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] +synonym: "peptidyl-diphthine breakdown" EXACT [] +synonym: "peptidyl-diphthine catabolism" EXACT [] +synonym: "peptidyl-diphthine degradation" EXACT [] +is_a: GO:0017179 ! peptidyl-diphthine metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017182 +name: peptidyl-diphthamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] +synonym: "peptidyl-diphthamide metabolism" EXACT [] +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0017183 +name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine +namespace: biological_process +def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] +synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT [] +synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT [] +xref: RESID:AA0040 +is_a: GO:0017182 ! peptidyl-diphthamide metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation + +[Term] +id: GO:0017184 +name: peptidyl-diphthamide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] +synonym: "peptidyl-diphthamide breakdown" EXACT [] +synonym: "peptidyl-diphthamide catabolism" EXACT [] +synonym: "peptidyl-diphthamide degradation" EXACT [] +is_a: GO:0017182 ! peptidyl-diphthamide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0017185 +name: peptidyl-lysine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai] +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0017186 +name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] +comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. +synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT [] +synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT [] +synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT [] +synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT [] +synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT [] +xref: RESID:AA0031 +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0017187 +name: peptidyl-glutamic acid carboxylation +namespace: biological_process +def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] +comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. +xref: RESID:AA0032 +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018214 ! protein carboxylation + +[Term] +id: GO:0017188 +name: aspartate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14165] +synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" RELATED [EC:2.3.1.17] +synonym: "aspartate acetyltransferase activity" RELATED [EC:2.3.1.17] +synonym: "L-aspartate N-acetyltransferase activity" RELATED [EC:2.3.1.17] +xref: EC:2.3.1.17 +xref: KEGG_REACTION:R00487 +xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN +xref: Reactome:R-HSA-8954468 "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA" +xref: RHEA:14165 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0017189 +name: N-terminal peptidyl-alanine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041] +comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. +xref: RESID:AA0041 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0017190 +name: N-terminal peptidyl-aspartic acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042] +comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. +xref: RESID:AA0042 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0017192 +name: N-terminal peptidyl-glutamine acetylation +namespace: biological_process +def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045] +xref: RESID:AA0045 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0017193 +name: N-terminal peptidyl-glycine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046] +xref: RESID:AA0046 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0017194 +name: N-terminal peptidyl-isoleucine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047] +xref: RESID:AA0047 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0017195 +name: N-terminal peptidyl-lysine N2-acetylation +namespace: biological_process +def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048] +xref: RESID:AA0048 +is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation + +[Term] +id: GO:0017196 +name: N-terminal peptidyl-methionine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049] +xref: RESID:AA0049 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0017197 +name: N-terminal peptidyl-proline acetylation +namespace: biological_process +def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050] +xref: RESID:AA0050 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0017198 +name: N-terminal peptidyl-serine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051] +xref: RESID:AA0051 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030920 ! peptidyl-serine acetylation + +[Term] +id: GO:0017199 +name: N-terminal peptidyl-threonine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052] +comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. +xref: RESID:AA0052 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0120257 ! peptidyl-threonine acetylation + +[Term] +id: GO:0018000 +name: N-terminal peptidyl-tyrosine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053] +xref: RESID:AA0053 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018001 +name: N-terminal peptidyl-valine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054] +xref: RESID:AA0054 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018213 ! peptidyl-valine modification + +[Term] +id: GO:0018002 +name: N-terminal peptidyl-glutamic acid acetylation +namespace: biological_process +def: "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044] +comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. +xref: RESID:AA0044 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018003 +name: peptidyl-lysine N6-acetylation +namespace: biological_process +def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055] +comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. +xref: RESID:AA0055 +is_a: GO:0018393 ! internal peptidyl-lysine acetylation + +[Term] +id: GO:0018004 +name: N-terminal protein formylation +namespace: biological_process +def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai] +is_a: GO:0018256 ! protein formylation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018005 +name: N-terminal peptidyl-glycine N-formylation +namespace: biological_process +def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057] +xref: RESID:AA0057 +is_a: GO:0018004 ! N-terminal protein formylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018006 +name: N-terminal protein amino acid glucuronylation +namespace: biological_process +def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai] +is_a: GO:0018321 ! protein glucuronylation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018007 +name: N-terminal peptidyl-glycine N-glucuronylation +namespace: biological_process +def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058] +xref: RESID:AA0058 +is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018008 +name: N-terminal peptidyl-glycine N-myristoylation +namespace: biological_process +def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059] +synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT [] +xref: RESID:AA0059 +is_a: GO:0006499 ! N-terminal protein myristoylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018009 +name: N-terminal peptidyl-L-cysteine N-palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060] +xref: RESID:AA0060 +is_a: GO:0006500 ! N-terminal protein palmitoylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018010 +name: glycoprotein N-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] +synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] +synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" RELATED [EC:2.3.1.96] +xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN +is_a: GO:0019105 ! N-palmitoyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0018011 +name: N-terminal peptidyl-alanine methylation +namespace: biological_process +def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062] +xref: RESID:AA0061 +xref: RESID:AA0062 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018012 +name: N-terminal peptidyl-alanine trimethylation +namespace: biological_process +def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062] +xref: RESID:AA0062 +is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation + +[Term] +id: GO:0018013 +name: N-terminal peptidyl-glycine methylation +namespace: biological_process +def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063] +xref: RESID:AA0063 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018014 +name: N-terminal peptidyl-methionine methylation +namespace: biological_process +def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064] +xref: RESID:AA0064 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018015 +name: N-terminal peptidyl-phenylalanine methylation +namespace: biological_process +def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065] +xref: RESID:AA0065 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018016 +name: N-terminal peptidyl-proline dimethylation +namespace: biological_process +def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066] +xref: RESID:AA0066 +is_a: GO:0035568 ! N-terminal peptidyl-proline methylation + +[Term] +id: GO:0018019 +name: N-terminal peptidyl-glutamine methylation +namespace: biological_process +def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071] +xref: RESID:AA0071 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018020 +name: peptidyl-glutamic acid methylation +namespace: biological_process +def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah] +is_a: GO:0006479 ! protein methylation + +[Term] +id: GO:0018021 +name: peptidyl-histidine methylation +namespace: biological_process +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317] +xref: RESID:AA0073 +xref: RESID:AA0317 +is_a: GO:0006479 ! protein methylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018022 +name: peptidyl-lysine methylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] +is_a: GO:0006479 ! protein methylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018023 +name: peptidyl-lysine trimethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] +xref: RESID:AA0074 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018024 +name: histone-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [RESID:AA0074, RESID:AA0075, RESID:AA0076] +synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" RELATED [] +synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah] +synonym: "protein (lysine) methyltransferase activity" RELATED [] +synonym: "protein methylase 3 activity" NARROW [] +synonym: "protein methylase III activity" NARROW [] +synonym: "protein methyltransferase II activity" NARROW [] +synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" RELATED [] +synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" RELATED [] +xref: EC:2.1.1.354 +xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-3788745 "EHMT1:EHMT2 methylates IL8 promoter" +xref: Reactome:R-HSA-3788748 "EHMT1:EHMT2 methylates IL6 promoter" +xref: Reactome:R-HSA-4827382 "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)" +xref: Reactome:R-HSA-4827383 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)" +xref: Reactome:R-HSA-5159245 "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)" +xref: Reactome:R-HSA-5244692 "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)" +xref: Reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)" +xref: Reactome:R-HSA-5634729 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)" +xref: Reactome:R-HSA-5634750 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)" +xref: Reactome:R-HSA-5634802 "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)" +xref: Reactome:R-HSA-5637686 "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)" +xref: Reactome:R-HSA-5638141 "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)" +xref: Reactome:R-HSA-5638157 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)" +xref: Reactome:R-HSA-5638332 "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)" +xref: Reactome:R-HSA-5638333 "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)" +xref: Reactome:R-HSA-5649764 "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)" +xref: Reactome:R-HSA-5649799 "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)" +xref: Reactome:R-HSA-5649800 "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)" +xref: Reactome:R-HSA-5649801 "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)" +xref: Reactome:R-HSA-5649802 "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)" +xref: Reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)" +xref: Reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)" +xref: RESID:AA0074 +xref: RESID:AA0075 +xref: RESID:AA0076 +xref: RHEA:10024 +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity +is_a: GO:0042054 ! histone methyltransferase activity + +[Term] +id: GO:0018025 +name: calmodulin-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] +synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.60] +synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.60] +synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" RELATED [EC:2.1.1.60] +xref: EC:2.1.1.60 +xref: MetaCyc:2.1.1.60-RXN +xref: Reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1" +xref: RHEA:21556 +is_a: GO:0016279 ! protein-lysine N-methyltransferase activity + +[Term] +id: GO:0018026 +name: peptidyl-lysine monomethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] +xref: RESID:AA0076 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018027 +name: peptidyl-lysine dimethylation +namespace: biological_process +def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] +xref: RESID:AA0075 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0018028 +name: peptidyl-lysine myristoylation +namespace: biological_process +def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078] +synonym: "peptidyl-lysine myristylation" EXACT [] +xref: RESID:AA0078 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018377 ! protein myristoylation + +[Term] +id: GO:0018029 +name: peptidyl-lysine palmitoylation +namespace: biological_process +def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077] +xref: RESID:AA0077 +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018030 +name: peptidyl-lysine N6-myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] +is_a: GO:0019107 ! myristoyltransferase activity + +[Term] +id: GO:0018031 +name: peptidyl-lysine N6-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] +xref: EC:2.3.1.- +is_a: GO:0019105 ! N-palmitoyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0018032 +name: protein amidation +namespace: biological_process +def: "Addition of an amide group from a glycine to a protein amino acid." [UniProtKB-KW:KW-0027] +synonym: "protein amino acid amidation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018033 +name: protein C-terminal amidation +namespace: biological_process +def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai] +is_a: GO:0018032 ! protein amidation +is_a: GO:0018410 ! C-terminal protein amino acid modification + +[Term] +id: GO:0018034 +name: C-terminal peptidyl-alanine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081] +xref: RESID:AA0081 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018035 +name: C-terminal peptidyl-arginine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082] +xref: RESID:AA0082 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018036 +name: C-terminal peptidyl-asparagine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083] +xref: RESID:AA0083 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018037 +name: C-terminal peptidyl-aspartic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084] +xref: RESID:AA0084 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018038 +name: C-terminal peptidyl-cysteine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085] +xref: RESID:AA0085 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018039 +name: C-terminal peptidyl-glutamine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086] +xref: RESID:AA0086 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018040 +name: C-terminal peptidyl-glutamic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087] +xref: RESID:AA0087 +is_a: GO:0018033 ! protein C-terminal amidation + +[Term] +id: GO:0018041 +name: C-terminal peptidyl-glycine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088] +xref: RESID:AA0088 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018042 +name: C-terminal peptidyl-histidine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089] +xref: RESID:AA0089 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018043 +name: C-terminal peptidyl-isoleucine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090] +xref: RESID:AA0090 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0018044 +name: C-terminal peptidyl-leucine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091] +xref: RESID:AA0091 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018204 ! peptidyl-leucine modification + +[Term] +id: GO:0018045 +name: C-terminal peptidyl-lysine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092] +xref: RESID:AA0092 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018046 +name: C-terminal peptidyl-methionine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093] +xref: RESID:AA0093 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018047 +name: C-terminal peptidyl-phenylalanine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094] +xref: RESID:AA0094 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018048 +name: C-terminal peptidyl-proline amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095] +xref: RESID:AA0095 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0018049 +name: C-terminal peptidyl-serine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096] +xref: RESID:AA0096 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018050 +name: C-terminal peptidyl-threonine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097] +xref: RESID:AA0097 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018051 +name: C-terminal peptidyl-tryptophan amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098] +xref: RESID:AA0098 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018052 +name: C-terminal peptidyl-tyrosine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099] +xref: RESID:AA0099 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018053 +name: C-terminal peptidyl-valine amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100] +xref: RESID:AA0100 +is_a: GO:0018033 ! protein C-terminal amidation +is_a: GO:0018213 ! peptidyl-valine modification + +[Term] +id: GO:0018054 +name: peptidyl-lysine biotinylation +namespace: biological_process +def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] +xref: RESID:AA0117 +is_a: GO:0009305 ! protein biotinylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018057 +name: peptidyl-lysine oxidation +namespace: biological_process +def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121] +xref: RESID:AA0121 +is_a: GO:0018158 ! protein oxidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018058 +name: N-terminal protein amino acid deamination, from amino carbon +namespace: biological_process +def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129] +xref: RESID:AA0127 +xref: RESID:AA0128 +xref: RESID:AA0129 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018277 ! protein deamination +is_a: GO:0031363 ! N-terminal protein amino acid deamination + +[Term] +id: GO:0018059 +name: N-terminal peptidyl-serine deamination +namespace: biological_process +def: "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018060 +name: N-terminal peptidyl-cysteine deamination +namespace: biological_process +def: "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018061 +name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine +namespace: biological_process +def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128] +synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT [] +synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT [] +synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT [] +xref: RESID:AA0128 +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018062 +name: peptidyl-tryptophan succinylation +namespace: biological_process +def: "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130] +xref: RESID:AA0130 +is_a: GO:0018211 ! peptidyl-tryptophan modification +is_a: GO:0018335 ! protein succinylation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018063 +name: cytochrome c-heme linkage +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135] +synonym: "cytochrome c-haem linkage" EXACT [] +xref: RESID:AA0134 +xref: RESID:AA0135 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018064 +name: protein-L-histidine N-tele-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [RHEA:19369] +synonym: "actin-specific histidine methyltransferase activity" RELATED [EC:2.1.1.85] +synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] +synonym: "protein (histidine) methyltransferase activity" RELATED [EC:2.1.1.85] +synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] +synonym: "protein-histidine N-methyltransferase activity" BROAD [] +synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" RELATED [EC:2.1.1.85] +synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" RELATED [EC:2.1.1.85] +xref: EC:2.1.1.85 +xref: MetaCyc:2.1.1.85-RXN +xref: RHEA:19369 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018065 +name: obsolete protein-cofactor linkage +namespace: biological_process +def: "OBSOLETE. The covalent attachment of a cofactor to a protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group protein modification processes that are not all chemically related by the fact that they may be used as a cofactor. +is_obsolete: true + +[Term] +id: GO:0018067 +name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146] +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0146 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation + +[Term] +id: GO:0018068 +name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147] +synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0147 +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018069 +name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone +namespace: biological_process +def: "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149] +xref: RESID:AA0149 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018070 +name: peptidyl-serine phosphopantetheinylation +namespace: biological_process +def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150] +xref: RESID:AA0150 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018215 ! protein phosphopantetheinylation + +[Term] +id: GO:0018071 +name: NAD(P)-cysteine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0018072 +name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid +namespace: biological_process +def: "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170] +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT [] +xref: RESID:AA0170 +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018073 +name: protein bromination +namespace: biological_process +def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah] +synonym: "protein amino acid bromination" EXACT [GOC:bf] +is_a: GO:0018079 ! protein halogenation + +[Term] +id: GO:0018074 +name: peptidyl-histidine bromination +namespace: biological_process +def: "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173] +xref: RESID:AA0173 +is_a: GO:0018073 ! protein bromination +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018075 +name: peptidyl-phenylalanine bromination +namespace: biological_process +def: "The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176] +xref: RESID:AA0174 +xref: RESID:AA0175 +xref: RESID:AA0176 +is_a: GO:0018073 ! protein bromination +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018076 +name: N-terminal peptidyl-lysine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai] +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:0018077 +name: protein iodination +namespace: biological_process +def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah] +synonym: "protein amino acid iodination" EXACT [GOC:bf] +is_a: GO:0018079 ! protein halogenation + +[Term] +id: GO:0018078 +name: peptidyl-thyronine iodination +namespace: biological_process +def: "The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178] +xref: RESID:AA0177 +xref: RESID:AA0178 +is_a: GO:0018077 ! protein iodination +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018079 +name: protein halogenation +namespace: biological_process +def: "The addition of a halogen to a protein amino acid." [GOC:ai] +synonym: "protein amino acid halogenation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0070276 ! halogen metabolic process + +[Term] +id: GO:0018080 +name: peptidyl-tryptophan bromination +namespace: biological_process +def: "The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179] +xref: RESID:AA0179 +is_a: GO:0018073 ! protein bromination +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018081 +name: peptide cross-linking via lanthionine or 3-methyl-lanthionine +namespace: biological_process +def: "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112] +synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT [] +synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT [] +xref: RESID:AA0110 +xref: RESID:AA0111 +xref: RESID:AA0112 +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018082 +name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine +namespace: biological_process +def: "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182] +synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT [] +synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT [] +synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT [] +xref: RESID:AA0182 +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018083 +name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine +namespace: biological_process +def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185] +synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT [] +synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT [] +synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT [] +xref: RESID:AA0185 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018084 +name: peptidyl-lactic acid biosynthetic process from peptidyl-serine +namespace: biological_process +def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186] +synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT [] +synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT [] +synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT [] +xref: RESID:AA0186 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018085 +name: peptidyl-L-amino acid racemization +namespace: biological_process +def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma] +is_a: GO:0018193 ! peptidyl-amino acid modification +is_a: GO:0018366 ! chiral amino acid racemization + +[Term] +id: GO:0018086 +name: obsolete alanine racemization +namespace: biological_process +alt_id: GO:0018368 +def: "OBSOLETE. (Was not defined before being made obsolete)." [RESID:AA0191] +comment: This term was made obsolete because it was replaced with more appropriate terms. +synonym: "alanine racemization" EXACT [] +is_obsolete: true +consider: GO:0019122 + +[Term] +id: GO:0018091 +name: peptidyl-asparagine racemization +namespace: biological_process +alt_id: GO:0018373 +alt_id: GO:0019127 +def: "The racemization of peptidyl-asparagine." [RESID:AA0196] +xref: RESID:AA0196 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018094 +name: protein polyglycylation +namespace: biological_process +def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] +xref: RESID:AA0201 +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018095 +name: protein polyglutamylation +namespace: biological_process +def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] +xref: RESID:AA0202 +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018096 +name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine +namespace: biological_process +def: "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204] +xref: RESID:AA0204 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018097 +name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine +namespace: biological_process +def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207] +synonym: "protein amino acid cinnamylation" BROAD [] +xref: RESID:AA0207 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018101 +name: protein citrullination +namespace: biological_process +def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [PMID:23175390, RESID:AA0214] +comment: Citrullination is distinct from the formation of the free amino acid citrulline (e.g. as part of the urea cycle). +synonym: "deimination" EXACT [Wikipedia:Citrullination] +synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT [] +synonym: "peptidyl-citrulline biosynthetic process from peptidyl-arginine" EXACT [RESID:AA0214] +synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT [] +synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT [] +xref: RESID:AA0214 +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018102 +name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine +namespace: biological_process +def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215] +xref: RESID:AA0215 +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0030961 ! peptidyl-arginine hydroxylation + +[Term] +id: GO:0018103 +name: protein C-linked glycosylation +namespace: biological_process +def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217] +synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf] +xref: RESID:AA0217 +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0018104 +name: peptidoglycan-protein cross-linking +namespace: biological_process +def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg] +is_a: GO:0009252 ! peptidoglycan biosynthetic process + +[Term] +id: GO:0018105 +name: peptidyl-serine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] +xref: RESID:AA0037 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018106 +name: peptidyl-histidine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036] +xref: RESID:AA0035 +xref: RESID:AA0036 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018107 +name: peptidyl-threonine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] +xref: RESID:AA0038 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018108 +name: peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] +xref: RESID:AA0039 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018109 +name: peptidyl-arginine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222] +xref: RESID:AA0222 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018110 +name: histone arginine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah] +synonym: "histone-arginine kinase activity" EXACT [] +xref: EC:2.7.3.- +is_a: GO:0004054 ! arginine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0018111 +name: methionine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12492] +xref: EC:5.1.1.2 +xref: KEGG_REACTION:R00655 +xref: MetaCyc:METHIONINE-RACEMASE-RXN +xref: RHEA:12492 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0018112 +name: proline racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10680] +xref: EC:5.1.1.4 +xref: KEGG_REACTION:R01255 +xref: MetaCyc:PROLINE-RACEMASE-RXN +xref: RHEA:10680 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0018113 +name: lysine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] +xref: EC:5.1.1.5 +xref: MetaCyc:LYSINE-RACEMASE-RXN +xref: RHEA:22864 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0018114 +name: threonine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13913] +xref: EC:5.1.1.6 +xref: KEGG_REACTION:R01467 +xref: MetaCyc:THREONINE-RACEMASE-RXN +xref: RHEA:13913 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0018115 +name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223] +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0223 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018116 +name: peptidyl-lysine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227] +synonym: "peptidyl-lysine adenylation" EXACT [] +xref: RESID:AA0227 +is_a: GO:0018117 ! protein adenylylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018117 +name: protein adenylylation +namespace: biological_process +alt_id: GO:0018176 +def: "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083] +synonym: "protein adenylation" EXACT [] +synonym: "protein amino acid adenylylation" EXACT [GOC:bf] +synonym: "protein AMPylation" EXACT [GOC:jsg, GOC:sart, PMID:21607083] +is_a: GO:0018175 ! protein nucleotidylation + +[Term] +id: GO:0018118 +name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229] +synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT [] +xref: RESID:AA0229 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018119 +name: peptidyl-cysteine S-nitrosylation +namespace: biological_process +def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230] +synonym: "protein S-nitrosylation" EXACT [PMID:20972426] +synonym: "S-nitrosylation" EXACT [PMID:20972426] +xref: RESID:AA0230 +is_a: GO:0017014 ! protein nitrosylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018120 +name: peptidyl-arginine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168] +xref: RESID:AA0168 +is_a: GO:0006471 ! protein ADP-ribosylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018121 +name: NAD(P)-asparagine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0018122 +name: peptidyl-asparagine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231] +xref: RESID:AA0231 +is_a: GO:0006471 ! protein ADP-ribosylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018123 +name: peptidyl-cysteine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169] +xref: RESID:AA0169 +is_a: GO:0006471 ! protein ADP-ribosylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018124 +name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone +namespace: biological_process +def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233] +xref: RESID:AA0233 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018125 +name: peptidyl-cysteine methylation +namespace: biological_process +def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234] +xref: RESID:AA0234 +is_a: GO:0006479 ! protein methylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018126 +name: protein hydroxylation +namespace: biological_process +def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] +synonym: "protein amino acid hydroxylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018127 +name: NAD(P)-serine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0018128 +name: obsolete peptidyl-serine cyclase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. +synonym: "peptidyl-serine cyclase activity" EXACT [] +xref: EC:4.2.1.- +is_obsolete: true + +[Term] +id: GO:0018129 +name: peptidyl-oxazoline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018130 +name: heterocycle biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] +synonym: "heterocycle anabolism" EXACT [] +synonym: "heterocycle biosynthesis" EXACT [] +synonym: "heterocycle formation" EXACT [] +synonym: "heterocycle synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0018131 +name: oxazole or thiazole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators] +synonym: "oxazole or thiazole anabolism" EXACT [] +synonym: "oxazole or thiazole biosynthesis" EXACT [] +synonym: "oxazole or thiazole formation" EXACT [] +synonym: "oxazole or thiazole synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046484 ! oxazole or thiazole metabolic process + +[Term] +id: GO:0018132 +name: peptide cross-linking via L-cysteine oxazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238] +xref: RESID:AA0238 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018133 +name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239] +xref: RESID:AA0239 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018134 +name: peptide cross-linking via glycine oxazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240] +xref: RESID:AA0240 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018135 +name: obsolete peptidyl-cysteine cyclase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. +synonym: "peptidyl-cysteine cyclase activity" EXACT [] +xref: EC:4.2.1.- +is_obsolete: true + +[Term] +id: GO:0018136 +name: peptidyl-thiazoline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018137 +name: peptide cross-linking via glycine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241] +xref: RESID:AA0241 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018138 +name: peptide cross-linking via L-serine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242] +xref: RESID:AA0242 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018139 +name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243] +xref: RESID:AA0243 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0018140 +name: peptide cross-linking via L-cysteine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244] +xref: RESID:AA0244 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018141 +name: peptide cross-linking via L-lysine thiazolecarboxylic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245] +xref: RESID:AA0245 +is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018142 +name: protein-DNA covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma] +synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah] +is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking + +[Term] +id: GO:0018143 +name: nucleic acid-protein covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018144 +name: RNA-protein covalent cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma] +is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking + +[Term] +id: GO:0018145 +name: protein-DNA covalent cross-linking via peptidyl-serine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246] +synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah] +xref: RESID:AA0246 +is_a: GO:0018142 ! protein-DNA covalent cross-linking +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018146 +name: keratan sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247] +synonym: "keratan sulfate anabolism" EXACT [] +synonym: "keratan sulfate biosynthesis" EXACT [] +synonym: "keratan sulfate formation" EXACT [] +synonym: "keratan sulfate synthesis" EXACT [] +synonym: "keratan sulphate biosynthesis" EXACT [] +synonym: "keratan sulphate biosynthetic process" EXACT [] +xref: RESID:AA0247 +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0042339 ! keratan sulfate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0018147 +name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248] +xref: RESID:AA0248 +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0018148 +name: RNA-protein covalent cross-linking via peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249] +xref: RESID:AA0249 +is_a: GO:0018144 ! RNA-protein covalent cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018149 +name: peptide cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018150 +name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine +namespace: biological_process +def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250] +xref: RESID:AA0250 +is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine + +[Term] +id: GO:0018151 +name: peptide cross-linking via L-histidyl-L-tyrosine +namespace: biological_process +def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai] +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018152 +name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine +namespace: biological_process +def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270] +xref: RESID:AA0270 +is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine + +[Term] +id: GO:0018153 +name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124] +xref: RESID:AA0124 +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018154 +name: peptide cross-linking via (2R,6R)-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110] +xref: RESID:AA0110 +is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018155 +name: peptide cross-linking via sn-(2S,6R)-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111] +xref: RESID:AA0111 +is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018156 +name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112] +xref: RESID:AA0112 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018157 +name: peptide cross-linking via an oxazole or thiazole +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg] +synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah] +synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah] +synonym: "peptide heterocycle formation" RELATED [GOC:mah] +synonym: "peptide heterocycle synthesis" RELATED [GOC:mah] +is_a: GO:0018131 ! oxazole or thiazole biosynthetic process +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018158 +name: protein oxidation +namespace: biological_process +def: "The modification of a protein amino acid by oxidation." [GOC:ai] +synonym: "protein amino acid oxidation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018159 +name: peptidyl-methionine oxidation +namespace: biological_process +def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251] +xref: RESID:AA0251 +is_a: GO:0018158 ! protein oxidation +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018160 +name: peptidyl-pyrromethane cofactor linkage +namespace: biological_process +alt_id: GO:0018354 +alt_id: GO:0033035 +def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [RESID:AA0252] +synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg] +synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg] +xref: RESID:AA0252 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018161 +name: dipyrrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] +synonym: "dipyrrin anabolism" EXACT [] +synonym: "dipyrrin biosynthesis" EXACT [] +synonym: "dipyrrin formation" EXACT [] +synonym: "dipyrrin synthesis" EXACT [] +synonym: "dipyrromethane biosynthesis" EXACT [] +synonym: "dipyrromethane biosynthetic process" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0046453 ! dipyrrin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0018162 +name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine +namespace: biological_process +def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253] +xref: RESID:AA0253 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018163 +name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254] +synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah] +xref: RESID:AA0254 +is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine + +[Term] +id: GO:0018164 +name: protein-DNA covalent cross-linking via peptidyl-threonine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255] +synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah] +xref: RESID:AA0255 +is_a: GO:0018142 ! protein-DNA covalent cross-linking +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018165 +name: peptidyl-tyrosine uridylylation +namespace: biological_process +def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256] +xref: RESID:AA0256 +is_a: GO:0018177 ! protein uridylylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018166 +name: C-terminal protein-tyrosinylation +namespace: biological_process +def: "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257] +comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. +xref: RESID:AA0257 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018322 ! protein tyrosinylation +is_a: GO:0018410 ! C-terminal protein amino acid modification + +[Term] +id: GO:0018167 +name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259] +xref: RESID:AA0259 +is_a: GO:0017011 ! protein-phycoerythrobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018168 +name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine +namespace: biological_process +def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132] +xref: RESID:AA0132 +is_a: GO:0017011 ! protein-phycoerythrobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018169 +name: ribosomal S6-glutamic acid ligase activity +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347] +is_a: GO:0070739 ! protein-glutamic acid ligase activity + +[Term] +id: GO:0018170 +name: C-terminal peptidyl-polyglutamic acid amidation +namespace: biological_process +def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261] +xref: RESID:AA0261 +is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018171 +name: peptidyl-cysteine oxidation +namespace: biological_process +def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262] +xref: RESID:AA0205 +xref: RESID:AA0262 +is_a: GO:0018158 ! protein oxidation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018172 +name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263] +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] +xref: RESID:AA0263 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation + +[Term] +id: GO:0018173 +name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process + +[Term] +id: GO:0018174 +name: protein-heme P460 linkage +namespace: biological_process +def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271] +synonym: "protein-haem P460 linkage" EXACT [] +xref: RESID:AA0266 +xref: RESID:AA0271 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018175 +name: protein nucleotidylation +namespace: biological_process +def: "The addition of a nucleotide to a protein amino acid." [GOC:ai] +synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018177 +name: protein uridylylation +namespace: biological_process +def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg] +synonym: "protein amino acid uridylylation" EXACT [GOC:bf] +is_a: GO:0018175 ! protein nucleotidylation + +[Term] +id: GO:0018178 +name: peptidyl-threonine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267] +synonym: "peptidyl-threonine adenylation" EXACT [] +xref: RESID:AA0267 +is_a: GO:0018117 ! protein adenylylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018179 +name: obsolete peptidyl-cysteine desulfurization +namespace: biological_process +def: "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269] +comment: This term was made obsolete because to does not correspond to a real process. +synonym: "peptidyl-cysteine desulfurization" EXACT [] +synonym: "peptidyl-cysteine desulphurization" EXACT [] +xref: RESID:AA0269 +is_obsolete: true + +[Term] +id: GO:0018180 +name: protein desulfurization +namespace: biological_process +def: "The removal of a sulfur group from a protein amino acid." [GOC:ai] +synonym: "protein amino acid desulfurisation" EXACT [] +synonym: "protein amino acid desulfurization" EXACT [GOC:bf] +synonym: "protein amino acid desulphurisation" EXACT [] +synonym: "protein amino acid desulphurization" EXACT [] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018181 +name: peptidyl-arginine C5-methylation +namespace: biological_process +def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272] +synonym: "peptidyl-arginine 5-methylation" EXACT [] +xref: RESID:AA0272 +is_a: GO:0035245 ! peptidyl-arginine C-methylation + +[Term] +id: GO:0018182 +name: protein-heme linkage via 3'-L-histidine +namespace: biological_process +def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276] +synonym: "protein-haem linkage via 3'-L-histidine" EXACT [] +xref: RESID:AA0276 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018183 +name: obsolete enzyme active site formation via S-selenyl-L-cysteine +namespace: biological_process +def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277] +comment: This term was made obsolete because this structure does not exist. +synonym: "enzyme active site formation via S-selenyl-L-cysteine" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018184 +name: protein polyamination +namespace: biological_process +def: "The modification of a protein amino acid by polyamination." [GOC:ai] +synonym: "protein amino acid polyamination" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018185 +name: poly-N-methyl-propylamination +namespace: biological_process +def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278] +xref: RESID:AA0278 +is_a: GO:0018184 ! protein polyamination +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018186 +name: peroxidase-heme linkage +namespace: biological_process +def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280] +synonym: "peroxidase-haem linkage" EXACT [] +xref: RESID:AA0279 +xref: RESID:AA0280 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0018187 +name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281] +xref: RESID:AA0281 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0018188 +name: peptidyl-proline di-hydroxylation +namespace: biological_process +def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282] +xref: RESID:AA0282 +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018189 +name: pyrroloquinoline quinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283] +synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT [] +synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT [] +synonym: "PQQ biosynthesis" EXACT [] +synonym: "PQQ biosynthetic process" EXACT [] +synonym: "pyrroloquinoline quinone anabolism" EXACT [] +synonym: "pyrroloquinoline quinone biosynthesis" EXACT [] +synonym: "pyrroloquinoline quinone formation" EXACT [] +synonym: "pyrroloquinoline quinone synthesis" EXACT [] +synonym: "pyrroloquinoline-quinone biosynthesis" EXACT [] +synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] +xref: RESID:AA0283 +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0018190 +name: protein octanoylation +namespace: biological_process +def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg] +synonym: "protein amino acid octanoylation" EXACT [GOC:bf] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0018191 +name: peptidyl-serine octanoylation +namespace: biological_process +def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290] +xref: RESID:AA0290 +is_a: GO:0018190 ! protein octanoylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018192 +name: obsolete enzyme active site formation via cysteine modification to L-cysteine persulfide +namespace: biological_process +def: "OBSOLETE. The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [RESID:AA0269] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11592406. +synonym: "enzyme active site formation via L-cysteine persulphide" EXACT [] +is_obsolete: true +consider: GO:0004792 + +[Term] +id: GO:0018193 +name: peptidyl-amino acid modification +namespace: biological_process +def: "The alteration of an amino acid residue in a peptide." [GOC:mah] +subset: goslim_yeast +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018194 +name: peptidyl-alanine modification +namespace: biological_process +def: "The modification of peptidyl-alanine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018195 +name: peptidyl-arginine modification +namespace: biological_process +def: "The modification of peptidyl-arginine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018196 +name: peptidyl-asparagine modification +namespace: biological_process +def: "The modification of peptidyl-asparagine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018197 +name: peptidyl-aspartic acid modification +namespace: biological_process +def: "The modification of peptidyl-aspartic acid." [GOC:ma] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018198 +name: peptidyl-cysteine modification +namespace: biological_process +def: "The modification of peptidyl-cysteine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018199 +name: peptidyl-glutamine modification +namespace: biological_process +def: "The modification of peptidyl-glutamine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018200 +name: peptidyl-glutamic acid modification +namespace: biological_process +def: "The modification of peptidyl-glutamic acid." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018201 +name: peptidyl-glycine modification +namespace: biological_process +def: "The modification of peptidyl-glycine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018202 +name: peptidyl-histidine modification +namespace: biological_process +def: "The modification of peptidyl-histidine." [GOC:ma] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018203 +name: peptidyl-isoleucine modification +namespace: biological_process +def: "The modification of peptidyl-isoleucine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018204 +name: peptidyl-leucine modification +namespace: biological_process +def: "The modification of peptidyl-leucine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018205 +name: peptidyl-lysine modification +namespace: biological_process +def: "The modification of peptidyl-lysine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018206 +name: peptidyl-methionine modification +namespace: biological_process +def: "The modification of peptidyl-methionine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018207 +name: peptidyl-phenylalanine modification +namespace: biological_process +def: "The modification of peptidyl-phenylalanine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018208 +name: peptidyl-proline modification +namespace: biological_process +def: "The modification of peptidyl-proline." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018209 +name: peptidyl-serine modification +namespace: biological_process +def: "The modification of peptidyl-serine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018210 +name: peptidyl-threonine modification +namespace: biological_process +def: "The modification of peptidyl-threonine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018211 +name: peptidyl-tryptophan modification +namespace: biological_process +def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018212 +name: peptidyl-tyrosine modification +namespace: biological_process +def: "The modification of peptidyl-tyrosine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018213 +name: peptidyl-valine modification +namespace: biological_process +def: "The modification of peptidyl-valine." [GOC:go_curators] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0018214 +name: protein carboxylation +namespace: biological_process +def: "The addition of a carboxy group to a protein amino acid." [GOC:ai] +synonym: "protein amino acid carboxylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018215 +name: protein phosphopantetheinylation +namespace: biological_process +def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] +synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018216 +name: peptidyl-arginine methylation +namespace: biological_process +alt_id: GO:0018017 +def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah] +is_a: GO:0006479 ! protein methylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0018217 +name: peptidyl-aspartic acid phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl] +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018218 +name: peptidyl-cysteine phosphorylation +namespace: biological_process +def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034] +xref: RESID:AA0034 +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018219 +name: peptidyl-cysteine S-acetylation +namespace: biological_process +def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056] +xref: RESID:AA0056 +is_a: GO:0018533 ! peptidyl-cysteine acetylation + +[Term] +id: GO:0018220 +name: peptidyl-threonine palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079] +comment: Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. +synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg] +xref: RESID:AA0079 +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0018345 ! protein palmitoylation + +[Term] +id: GO:0018221 +name: peptidyl-serine palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080] +comment: Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom. +synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg] +xref: RESID:AA0080 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018345 ! protein palmitoylation + +[Term] +id: GO:0018222 +name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101] +synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT [] +xref: RESID:AA0101 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018226 +name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102] +synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0102 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018343 ! protein farnesylation + +[Term] +id: GO:0018227 +name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103] +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0103 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018343 ! protein farnesylation + +[Term] +id: GO:0018228 +name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104] +synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0104 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018344 ! protein geranylgeranylation + +[Term] +id: GO:0018229 +name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105] +synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0105 +is_a: GO:0006481 ! C-terminal protein methylation +is_a: GO:0018351 ! peptidyl-cysteine esterification + +[Term] +id: GO:0018230 +name: peptidyl-L-cysteine S-palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106] +comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom. +synonym: "peptidyl-cysteine S-palmitoylation" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0106 +is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine +is_a: GO:0018345 ! protein palmitoylation + +[Term] +id: GO:0018231 +name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107] +synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0107 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018232 +name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine +namespace: biological_process +def: "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108] +xref: RESID:AA0108 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0018233 +name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine +namespace: biological_process +def: "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109] +xref: RESID:AA0109 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0018234 +name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine +namespace: biological_process +def: "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113] +xref: RESID:AA0113 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018235 +name: peptidyl-lysine carboxylation +namespace: biological_process +def: "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114] +xref: RESID:AA0114 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018214 ! protein carboxylation + +[Term] +id: GO:0018237 +name: urease activator activity +namespace: molecular_function +def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137] +synonym: "urease activase activity" EXACT [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0018238 +name: peptidyl-lysine carboxyethylation +namespace: biological_process +alt_id: GO:0018239 +def: "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115] +synonym: "protein amino acid carboxyethylation" EXACT [] +xref: RESID:AA0115 +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018240 +name: protein S-linked glycosylation via cysteine +namespace: biological_process +def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152] +synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf] +xref: RESID:AA0152 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018280 ! protein S-linked glycosylation + +[Term] +id: GO:0018241 +name: protein O-linked glycosylation via hydroxylysine +namespace: biological_process +def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153] +synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf] +xref: RESID:AA0153 +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018242 +name: protein O-linked glycosylation via serine +namespace: biological_process +def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154] +synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf] +xref: RESID:AA0154 +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018243 +name: protein O-linked glycosylation via threonine +namespace: biological_process +def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155] +synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf] +xref: RESID:AA0155 +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018244 +name: protein N-linked glycosylation via tryptophan +namespace: biological_process +def: "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156] +synonym: "protein amino acid N-linked glycosylation via tryptophan" EXACT [GOC:bf] +xref: RESID:AA0156 +is_a: GO:0006487 ! protein N-linked glycosylation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018245 +name: protein O-linked glycosylation via tyrosine +namespace: biological_process +def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157] +synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf] +xref: RESID:AA0157 +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018246 +name: protein-coenzyme A linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018247 +name: protein-phosphoribosyl dephospho-coenzyme A linkage +namespace: biological_process +def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167] +xref: RESID:AA0167 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018246 ! protein-coenzyme A linkage + +[Term] +id: GO:0018248 +name: obsolete enzyme active site formation via peptidyl cysteine sulfation +namespace: biological_process +def: "OBSOLETE. The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] +comment: This term was obsoleted because it was created by error: cysteine sulfation is a post-translational modification, see PMID:12876326. +synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018249 +name: protein dehydration +namespace: biological_process +def: "The removal of a water group from a protein amino acid." [GOC:ai] +synonym: "protein amino acid dehydration" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018250 +name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine +namespace: biological_process +def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181] +synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT [] +synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT [] +synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT [] +xref: RESID:AA0181 +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018249 ! protein dehydration +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0018251 +name: peptidyl-tyrosine dehydrogenation +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183] +comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. +xref: RESID:AA0183 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018249 ! protein dehydration + +[Term] +id: GO:0018252 +name: peptide cross-linking via L-seryl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0184 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018253 +name: peptide cross-linking via 5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188] +synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0184 +xref: RESID:AA0187 +xref: RESID:AA0188 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018254 +name: peptidyl-tyrosine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203] +synonym: "peptidyl-tyrosine adenylation" EXACT [] +xref: RESID:AA0203 +is_a: GO:0018117 ! protein adenylylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018255 +name: peptide cross-linking via S-glycyl-L-cysteine +namespace: biological_process +def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206] +xref: RESID:AA0206 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018256 +name: protein formylation +namespace: biological_process +def: "The addition of a formyl group to a protein amino acid." [GOC:ai] +synonym: "protein amino acid formylation" EXACT [GOC:bf] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0018257 +name: peptidyl-lysine formylation +namespace: biological_process +def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211] +xref: RESID:AA0211 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018256 ! protein formylation + +[Term] +id: GO:0018258 +name: protein O-linked glycosylation via hydroxyproline +namespace: biological_process +def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212] +synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf] +xref: RESID:AA0212 +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0018259 +name: RNA-protein covalent cross-linking via peptidyl-serine +namespace: biological_process +def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213] +xref: RESID:AA0213 +is_a: GO:0018144 ! RNA-protein covalent cross-linking +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018260 +name: protein guanylylation +namespace: biological_process +def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai] +synonym: "protein amino acid guanylylation" EXACT [GOC:bf] +is_a: GO:0018175 ! protein nucleotidylation + +[Term] +id: GO:0018261 +name: peptidyl-lysine guanylylation +namespace: biological_process +def: "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228] +xref: RESID:AA0228 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018260 ! protein guanylylation + +[Term] +id: GO:0018262 +name: isopeptide cross-linking +namespace: biological_process +def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg] +is_a: GO:0018149 ! peptide cross-linking + +[Term] +id: GO:0018263 +name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216] +xref: RESID:AA0216 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018264 +name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126] +xref: RESID:AA0126 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0018265 +name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158] +synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0158 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018266 +name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159] +synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0159 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0018267 +name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160] +synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0160 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018268 +name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161] +synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0161 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0018269 +name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162] +synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0162 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018270 +name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163] +synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0163 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0018271 +name: biotin-protein ligase activity +namespace: molecular_function +alt_id: GO:0000106 +def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] +synonym: "biotin-apoprotein ligase activity" EXACT [] +xref: EC:6.3.4.- +xref: MetaCyc:BIOTINLIG-RXN +xref: Reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)" +xref: Reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2" +xref: Reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+" +xref: Reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+" +xref: Reactome:R-HSA-3323184 "Defective HLCS does not biotinylate ACACA:Mn2+" +xref: Reactome:R-HSA-4167511 "HLCS biotinylates ACACB" +xref: Reactome:R-HSA-9035987 "Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2" +xref: Reactome:R-HSA-9035988 "Defective HLCS does not biotinylate PC:Mn2+" +xref: Reactome:R-HSA-9035990 "Defective HLCS does not biotinylate 6x(PCCA:PCCB)" +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0018272 +name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine +namespace: biological_process +def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119] +xref: RESID:AA0119 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage + +[Term] +id: GO:0018273 +name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine +namespace: biological_process +def: "The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120] +xref: RESID:AA0120 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0018274 +name: peptide cross-linking via L-lysinoalanine +namespace: biological_process +def: "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123] +xref: RESID:AA0123 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018275 +name: N-terminal peptidyl-cysteine acetylation +namespace: biological_process +alt_id: GO:0017191 +def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043] +synonym: "peptidyl-cysteine N-acetylation" EXACT [] +xref: RESID:AA0043 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018533 ! peptidyl-cysteine acetylation + +[Term] +id: GO:0018276 +name: isopeptide cross-linking via N6-glycyl-L-lysine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125] +comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. +xref: RESID:AA0125 +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018262 ! isopeptide cross-linking +relationship: part_of GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0018277 +name: protein deamination +namespace: biological_process +def: "The removal of an amino group from a protein amino acid." [GOC:ai] +synonym: "protein amino acid deamination" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018278 +name: N-terminal peptidyl-threonine deamination +namespace: biological_process +def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129] +xref: RESID:AA0129 +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018279 +name: protein N-linked glycosylation via asparagine +namespace: biological_process +def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421] +synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf] +is_a: GO:0006487 ! protein N-linked glycosylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018280 +name: protein S-linked glycosylation +namespace: biological_process +def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr] +synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0018281 +name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine +namespace: biological_process +def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166] +synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] +xref: RESID:AA0166 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0042082 ! GSI anchor biosynthetic process + +[Term] +id: GO:0018282 +name: metal incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg] +synonym: "metal incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0006464 ! cellular protein modification process +relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0018283 +name: iron incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai] +synonym: "iron incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018284 +name: iron incorporation into protein via tetrakis-L-cysteinyl iron +namespace: biological_process +def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136] +xref: RESID:AA0136 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018285 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137] +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT [] +xref: RESID:AA0137 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018286 +name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide +namespace: biological_process +def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138] +comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form. +synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide" EXACT [] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT [] +is_obsolete: true +consider: GO:0018198 +consider: GO:0018283 + +[Term] +id: GO:0018287 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT [] +xref: RESID:AA0139 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018288 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140] +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0140 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018289 +name: molybdenum incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai] +synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018290 +name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide +namespace: biological_process +def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141] +synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT [] +xref: RESID:AA0141 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster + +[Term] +id: GO:0018291 +name: molybdenum incorporation into iron-sulfur cluster +namespace: biological_process +def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai] +synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018292 +name: molybdenum incorporation via L-cysteinyl molybdopterin +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142] +xref: RESID:AA0142 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0018293 +name: protein-FAD linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018294 +name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143] +xref: RESID:AA0143 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018295 +name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine +namespace: biological_process +def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144] +xref: RESID:AA0144 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018296 +name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine +namespace: biological_process +def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145] +xref: RESID:AA0145 +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018297 +name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine +namespace: biological_process +def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221] +xref: RESID:AA0221 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018293 ! protein-FAD linkage + +[Term] +id: GO:0018298 +name: protein-chromophore linkage +namespace: biological_process +def: "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018299 +name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225] +synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT [] +xref: RESID:AA0225 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018300 +name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide +namespace: biological_process +def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226] +comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist. +synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide" EXACT [] +synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT [] +is_obsolete: true +consider: GO:0018198 +consider: GO:0018283 + +[Term] +id: GO:0018301 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon +namespace: biological_process +def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT [] +xref: RESID:AA0268 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018302 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0284 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018303 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0285 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018304 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0286 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018305 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0288 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018306 +name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289] +synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT [] +xref: RESID:AA0289 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018307 +name: obsolete enzyme active site formation +namespace: biological_process +def: "OBSOLETE. The modification of part of an enzyme to form the active site." [GOC:ai] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see https://en.wikipedia.org/wiki/Active_site#Mechanisms_involved_in_Catalytic_process. +is_obsolete: true + +[Term] +id: GO:0018308 +name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine +namespace: biological_process +def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287] +comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. +synonym: "enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018309 +name: protein-FMN linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018310 +name: protein-FMN linkage via S-(6-FMN)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220] +xref: RESID:AA0220 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0018311 +name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236] +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT [] +xref: RESID:AA0236 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0018312 +name: peptidyl-serine ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237] +xref: RESID:AA0237 +is_a: GO:0006471 ! protein ADP-ribosylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018313 +name: peptide cross-linking via L-alanyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187] +xref: RESID:AA0187 +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine + +[Term] +id: GO:0018314 +name: obsolete protein-pyrroloquinoline-quinone linkage +namespace: biological_process +def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283] +synonym: "protein-pyrroloquinoline-quinone linkage" EXACT [] +is_obsolete: true +replaced_by: GO:0006464 + +[Term] +id: GO:0018315 +name: molybdenum incorporation into molybdenum-molybdopterin complex +namespace: biological_process +alt_id: GO:0042041 +def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai] +synonym: "molybdenum incorporation into metallo-pterin complex" EXACT [] +is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex + +[Term] +id: GO:0018316 +name: peptide cross-linking via L-cystine +namespace: biological_process +def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025] +xref: RESID:AA0025 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018317 +name: protein C-linked glycosylation via tryptophan +namespace: biological_process +def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai] +synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf] +is_a: GO:0018103 ! protein C-linked glycosylation +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0018320 +name: obsolete enzyme active site formation via S-methyl-L-cysteine +namespace: biological_process +def: "OBSOLETE. The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:21527678. +xref: RESID:AA0234 +is_obsolete: true +consider: GO:0008757 + +[Term] +id: GO:0018321 +name: protein glucuronylation +namespace: biological_process +def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr] +synonym: "protein amino acid glucuronylation" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0018322 +name: protein tyrosinylation +namespace: biological_process +def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai] +synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018323 +name: obsolete enzyme active site formation via L-cysteine sulfinic acid +namespace: biological_process +def: "OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:9586994. +synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT [] +xref: RESID:AA0262 +is_obsolete: true +consider: GO:0018822 + +[Term] +id: GO:0018324 +name: obsolete enzyme active site formation via L-cysteine sulfenic acid +namespace: biological_process +def: "OBSOLETE. The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:10964927 and PMID:9587003. +synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT [] +xref: RESID:AA0205 +is_obsolete: true + +[Term] +id: GO:0018325 +name: obsolete enzyme active site formation via S-phospho-L-cysteine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:3142516 and PMID:22927394. +xref: RESID:AA0034 +is_obsolete: true + +[Term] +id: GO:0018326 +name: obsolete enzyme active site formation via S-acetyl-L-cysteine +namespace: biological_process +def: "OBSOLETE. The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:1310545. +xref: RESID:AA0056 +is_obsolete: true + +[Term] +id: GO:0018327 +name: obsolete enzyme active site formation via 1'-phospho-L-histidine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11038361. +xref: RESID:AA0035 +is_obsolete: true +consider: GO:0008257 + +[Term] +id: GO:0018328 +name: obsolete enzyme active site formation via 3'-phospho-L-histidine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:11168390. +xref: RESID:AA0036 +is_obsolete: true +consider: GO:0008256 + +[Term] +id: GO:0018329 +name: obsolete enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine +namespace: biological_process +def: "OBSOLETE. The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:4944632 and and PMID:3882425. +xref: RESID:AA0227 +is_obsolete: true +consider: GO:0003910 + +[Term] +id: GO:0018330 +name: obsolete enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine +namespace: biological_process +def: "OBSOLETE. The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:6092377. +xref: RESID:AA0228 +is_obsolete: true +consider: GO:0070568 + +[Term] +id: GO:0018331 +name: obsolete enzyme active site formation via O-phospho-L-serine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:8061611 and PMID:12923550. +xref: RESID:AA0037 +is_obsolete: true + +[Term] +id: GO:0018332 +name: obsolete enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine +namespace: biological_process +def: "OBSOLETE. The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:19039103 and PMID:19503829. +xref: RESID:AA0267 +is_obsolete: true + +[Term] +id: GO:0018333 +name: obsolete enzyme active site formation via O-phospho-L-threonine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038] +comment: This term was obsoleted because it was created by error: tyrosine phosphorylation does not generate an active site. +xref: RESID:AA0038 +is_obsolete: true + +[Term] +id: GO:0018334 +name: obsolete enzyme active site formation via O4'-phospho-L-tyrosine +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039] +comment: This term was obsoleted because it was created by error: O4'-phospho-L-tyrosine is a post-translational modification, see PMID:1725475. +xref: RESID:AA0039 +is_obsolete: true + +[Term] +id: GO:0018335 +name: protein succinylation +namespace: biological_process +def: "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [GOC:bf] +synonym: "protein amino acid succinylation" EXACT [GOC:bf] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0018336 +name: peptidyl-tyrosine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai] +is_a: GO:0018126 ! protein hydroxylation + +[Term] +id: GO:0018337 +name: obsolete enzyme active site formation via L-2',4',5'-topaquinone +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. +synonym: "enzyme active site formation via L-2',4',5'-topaquinone" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018338 +name: obsolete protein amino acid cinnamylation +namespace: biological_process +def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "protein amino acid cinnamylation" EXACT [] +is_obsolete: true +consider: GO:0018097 + +[Term] +id: GO:0018339 +name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232] +synonym: "peptidyl-aspartic acid methylthiolation" EXACT [] +synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] +xref: RESID:AA0232 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018340 +name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine +namespace: biological_process +def: "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264] +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT [] +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT [] +synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT [] +xref: RESID:AA0264 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018341 +name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine +namespace: biological_process +def: "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT [] +synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT [] +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018342 +name: protein prenylation +namespace: biological_process +alt_id: GO:0018346 +def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732] +synonym: "C-terminal protein prenylation" NARROW [] +synonym: "protein amino acid prenylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0097354 ! prenylation + +[Term] +id: GO:0018343 +name: protein farnesylation +namespace: biological_process +alt_id: GO:0018347 +def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl] +synonym: "C-terminal protein farnesylation" NARROW [] +synonym: "protein amino acid farnesylation" EXACT [GOC:bf] +is_a: GO:0018342 ! protein prenylation + +[Term] +id: GO:0018344 +name: protein geranylgeranylation +namespace: biological_process +alt_id: GO:0018348 +def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl] +synonym: "C-terminal protein geranylgeranylation" NARROW [] +synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf] +is_a: GO:0018342 ! protein prenylation + +[Term] +id: GO:0018345 +name: protein palmitoylation +namespace: biological_process +alt_id: GO:0018318 +alt_id: GO:0018349 +def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] +synonym: "protein amino acid palmitoylation" EXACT [GOC:bf] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0018350 +name: protein esterification +namespace: biological_process +def: "The addition of an ester group to a protein amino acid." [GOC:ai] +synonym: "protein amino acid esterification" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018351 +name: peptidyl-cysteine esterification +namespace: biological_process +def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah] +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0018352 +name: protein-pyridoxal-5-phosphate linkage +namespace: biological_process +def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018353 +name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine +namespace: biological_process +alt_id: GO:0018380 +def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131] +xref: RESID:AA0131 +is_a: GO:0017009 ! protein-phycocyanobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018355 +name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine +namespace: biological_process +def: "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167] +is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage + +[Term] +id: GO:0018356 +name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine +namespace: biological_process +alt_id: GO:0018382 +def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258] +xref: RESID:AA0258 +is_a: GO:0017008 ! protein-phycobiliviolin linkage + +[Term] +id: GO:0018357 +name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine +namespace: biological_process +alt_id: GO:0018383 +def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260] +xref: RESID:AA0260 +is_a: GO:0017010 ! protein-phycourobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018358 +name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine +namespace: biological_process +alt_id: GO:0018381 +def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133] +xref: RESID:AA0133 +is_a: GO:0017012 ! protein-phytochromobilin linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018359 +name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine +namespace: biological_process +alt_id: GO:0018385 +def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266] +synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT [] +xref: RESID:AA0266 +is_a: GO:0018174 ! protein-heme P460 linkage +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0018360 +name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine +namespace: biological_process +alt_id: GO:0018384 +def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271] +synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT [] +xref: RESID:AA0271 +is_a: GO:0018174 ! protein-heme P460 linkage +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018361 +name: peptidyl-glutamine 2-methylation +namespace: biological_process +def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273] +xref: RESID:AA0273 +is_a: GO:0018364 ! peptidyl-glutamine methylation + +[Term] +id: GO:0018362 +name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester +namespace: biological_process +alt_id: GO:0019924 +def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279] +synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT [] +xref: RESID:AA0279 +is_a: GO:0018186 ! peroxidase-heme linkage +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018363 +name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium +namespace: biological_process +alt_id: GO:0019925 +def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280] +synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT [] +synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT [] +xref: RESID:AA0280 +is_a: GO:0018186 ! peroxidase-heme linkage +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018206 ! peptidyl-methionine modification + +[Term] +id: GO:0018364 +name: peptidyl-glutamine methylation +namespace: biological_process +def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah] +is_a: GO:0006479 ! protein methylation + +[Term] +id: GO:0018365 +name: protein-serine epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] +synonym: "protein-serine racemase activity" RELATED [EC:5.1.1.16] +xref: EC:5.1.1.16 +xref: MetaCyc:5.1.1.16-RXN +xref: RHEA:10660 +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0018366 +name: chiral amino acid racemization +namespace: biological_process +def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732] +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0018367 +name: obsolete free L-amino acid racemization +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is not clear that this process occurs. +synonym: "free L-amino acid racemization" EXACT [] +is_obsolete: true +consider: GO:0006520 + +[Term] +id: GO:0018376 +name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine +namespace: biological_process +def: "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026] +comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. +xref: RESID:AA0026 +is_a: GO:0042265 ! peptidyl-asparagine hydroxylation + +[Term] +id: GO:0018377 +name: protein myristoylation +namespace: biological_process +alt_id: GO:0018319 +def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai] +synonym: "protein amino acid myristoylation" EXACT [GOC:bf] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0018378 +name: cytochrome c-heme linkage via heme-L-cysteine +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135] +synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT [] +xref: RESID:AA0135 +is_a: GO:0018063 ! cytochrome c-heme linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018379 +name: cytochrome c-heme linkage via heme-bis-L-cysteine +namespace: biological_process +def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134] +synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT [] +xref: RESID:AA0134 +is_a: GO:0018063 ! cytochrome c-heme linkage +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018386 +name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine +namespace: biological_process +def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274] +xref: RESID:AA0274 +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018387 +name: N-terminal peptidyl-amino acid deamination to pyruvic acid +namespace: biological_process +def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] +xref: RESID:AA0127 +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018388 +name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine +namespace: biological_process +def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275] +xref: RESID:AA0275 +is_a: GO:0018213 ! peptidyl-valine modification +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0018389 +name: N-terminal peptidyl-valine deamination +namespace: biological_process +def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah] +is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon + +[Term] +id: GO:0018390 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine +namespace: biological_process +def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072] +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] +xref: RESID:AA0072 +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018442 ! peptidyl-glutamic acid esterification + +[Term] +id: GO:0018391 +name: C-terminal peptidyl-glutamic acid tyrosinylation +namespace: biological_process +def: "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah] +is_a: GO:0018166 ! C-terminal protein-tyrosinylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018392 +name: glycoprotein 3-alpha-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24444] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] +synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" RELATED [EC:2.4.1.214] +synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" RELATED [EC:2.4.1.214] +xref: EC:2.4.1.214 +xref: KEGG_REACTION:R06015 +xref: MetaCyc:2.4.1.214-RXN +xref: RHEA:24444 +is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0018393 +name: internal peptidyl-lysine acetylation +namespace: biological_process +def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] +is_a: GO:0006475 ! internal protein amino acid acetylation +is_a: GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:0018394 +name: peptidyl-lysine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-lysine." [GOC:mah] +is_a: GO:0006473 ! protein acetylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018395 +name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028] +xref: RESID:AA0028 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0018396 +name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235] +xref: RESID:AA0235 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0018397 +name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine +namespace: biological_process +def: "The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174] +xref: RESID:AA0174 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018398 +name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine +namespace: biological_process +def: "The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175] +xref: RESID:AA0175 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018399 +name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine +namespace: biological_process +def: "The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176] +xref: RESID:AA0176 +is_a: GO:0018075 ! peptidyl-phenylalanine bromination + +[Term] +id: GO:0018400 +name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline +namespace: biological_process +def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029] +comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. +xref: RESID:AA0029 +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018401 +name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline +namespace: biological_process +def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030] +comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. +xref: RESID:AA0030 +is_a: GO:0019511 ! peptidyl-proline hydroxylation + +[Term] +id: GO:0018402 +name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208] +synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0208 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030204 ! chondroitin sulfate metabolic process + +[Term] +id: GO:0018403 +name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209] +synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0209 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018404 +name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine +namespace: biological_process +def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210] +synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] +xref: RESID:AA0210 +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0018405 +name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine +namespace: biological_process +def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247] +synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT [] +xref: RESID:AA0247 +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0018406 +name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan +namespace: biological_process +alt_id: GO:0032004 +def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217] +synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf] +synonym: "protein amino acid C-linked mannosylation" EXACT [] +xref: RESID:AA0217 +is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan +is_a: GO:0035268 ! protein mannosylation + +[Term] +id: GO:0018407 +name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine +namespace: biological_process +def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177] +synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD [] +xref: RESID:AA0177 +is_a: GO:0018078 ! peptidyl-thyronine iodination + +[Term] +id: GO:0018408 +name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine +namespace: biological_process +def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178] +xref: RESID:AA0178 +is_a: GO:0018078 ! peptidyl-thyronine iodination + +[Term] +id: GO:0018410 +name: C-terminal protein amino acid modification +namespace: biological_process +def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah] +synonym: "peptide or protein carboxyl-terminal blocking" RELATED [] +synonym: "peptide/protein carboxyl-terminal blocking" RELATED [] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0018411 +name: protein glucuronidation +namespace: biological_process +def: "The modification of a protein by amino acid glucuronidation." [GOC:ai] +synonym: "protein amino acid glucuronidation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0018412 +name: protein O-glucuronidation +namespace: biological_process +def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah] +synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf] +is_a: GO:0018411 ! protein glucuronidation + +[Term] +id: GO:0018413 +name: peptidyl-serine O-glucuronidation +namespace: biological_process +def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291] +xref: RESID:AA0291 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018412 ! protein O-glucuronidation + +[Term] +id: GO:0018414 +name: nickel incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai] +synonym: "nickel incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018415 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0292 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018416 +name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] +synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0292 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018417 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0293 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018418 +name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide +namespace: biological_process +def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] +synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] +xref: RESID:AA0 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018419 +name: protein catenane formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0018420 +name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine +namespace: biological_process +def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294] +xref: RESID:AA0294 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0018421 +name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0018422 +name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0018423 +name: protein C-terminal leucine carboxyl O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774] +synonym: "protein phosphatase methyltransferase activity" NARROW [] +synonym: "protein-leucine O-methyltransferase activity" EXACT [] +xref: Reactome:R-HSA-8856945 "PP2A methylation by LCMT1" +is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018424 +name: peptidyl-glutamic acid poly-ADP-ribosylation +namespace: biological_process +def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295] +xref: RESID:AA0295 +is_a: GO:0006471 ! protein ADP-ribosylation +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0018425 +name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT [] +synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT [] +xref: RESID:AA0296 +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0046349 ! amino sugar biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0018426 +name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT [] +synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT [] +xref: RESID:AA0297 +is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine + +[Term] +id: GO:0018427 +name: copper incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai] +synonym: "copper incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018428 +name: copper incorporation into copper-sulfur cluster +namespace: biological_process +def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai] +synonym: "copper incorporation into copper-sulphur cluster" EXACT [] +is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster + +[Term] +id: GO:0018429 +name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide +namespace: biological_process +def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298] +synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT [] +xref: RESID:AA0298 +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster + +[Term] +id: GO:0018439 +name: peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine +namespace: biological_process +alt_id: GO:0018440 +def: "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299] +synonym: "peptidyl-leucine esterification" EXACT [] +xref: RESID:AA0299 +is_a: GO:0006481 ! C-terminal protein methylation +is_a: GO:0018203 ! peptidyl-isoleucine modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0018441 +name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide +namespace: biological_process +def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300] +synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT [] +xref: RESID:AA0300 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide + +[Term] +id: GO:0018442 +name: peptidyl-glutamic acid esterification +namespace: biological_process +def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah] +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0018443 +name: obsolete enzyme active site formation via L-aspartic 4-phosphoric anhydride +namespace: biological_process +def: "OBSOLETE. The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:4357737. +xref: RESID:AA0033 +is_obsolete: true + +[Term] +id: GO:0018444 +name: translation release factor complex +namespace: cellular_component +def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] +synonym: "eukaryotic peptide chain release factor" EXACT [] +synonym: "peptide chain release factor" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0018445 +name: prothoracicotrophic hormone activity +namespace: molecular_function +def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403] +is_a: GO:0005184 ! neuropeptide hormone activity + +[Term] +id: GO:0018446 +name: pinocarveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0717] +xref: UM-BBD_reactionID:r0717 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018447 +name: chloral hydrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] +xref: UM-BBD_enzymeID:e0229 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018448 +name: hydroxymethylmethylsilanediol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638] +xref: UM-BBD_reactionID:r0638 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018449 +name: 1-phenylethanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_reactionID:r0032] +xref: UM-BBD_reactionID:r0032 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018450 +name: myrtenol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710] +xref: UM-BBD_reactionID:r0710 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018451 +name: epoxide dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595] +xref: UM-BBD_reactionID:r0595 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018452 +name: 5-exo-hydroxycamphor dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427] +xref: EC:1.1.1.327 +xref: MetaCyc:R542-RXN +xref: RHEA:32879 +xref: UM-BBD_reactionID:r0427 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018453 +name: 2-hydroxytetrahydrofuran dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018] +xref: UM-BBD_reactionID:r0018 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018454 +name: acetoacetyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] +synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" RELATED [EC:1.1.1.36] +synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.36] +synonym: "acetoacetyl coenzyme A reductase activity" RELATED [EC:1.1.1.36] +synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] +synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" RELATED [EC:1.1.1.36] +synonym: "D-3-hydroxyacyl-CoA reductase activity" RELATED [EC:1.1.1.36] +synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" RELATED [EC:1.1.1.36] +synonym: "NADP-linked acetoacetyl CoA reductase activity" RELATED [EC:1.1.1.36] +synonym: "NADPH:acetoacetyl-CoA reductase activity" RELATED [EC:1.1.1.36] +synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" RELATED [EC:1.1.1.36] +xref: EC:1.1.1.36 +xref: MetaCyc:RXN-7698 +xref: RHEA:22256 +xref: UM-BBD_reactionID:r0202 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018455 +name: alcohol dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] +synonym: "alcohol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.71] +synonym: "aldehyde reductase (NADPH/NADH)" RELATED [EC:1.1.1.71] +xref: EC:1.1.1.71 +xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:10736 +xref: UM-BBD_reactionID:r0172 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018456 +name: aryl-alcohol dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] +synonym: "aryl-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.90] +synonym: "benzyl alcohol dehydrogenase activity" NARROW [] +synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] +xref: EC:1.1.1.90 +xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:12076 +xref: UM-BBD_enzymeID:e0019 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018457 +name: perillyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10664] +synonym: "perillyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.144] +synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.144] +xref: EC:1.1.1.144 +xref: KEGG_REACTION:R03945 +xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:10664 +xref: UM-BBD_reactionID:r0729 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018458 +name: isopiperitenol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20860] +synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.223] +xref: EC:1.1.1.223 +xref: KEGG_REACTION:R03261 +xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN +xref: RHEA:20860 +xref: UM-BBD_reactionID:r0740 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018459 +name: carveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13629] +synonym: "(-)-trans-carveol dehydrogenase activity" RELATED [EC:1.1.1.243] +synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.243] +xref: EC:1.1.1.243 +xref: KEGG_REACTION:R03114 +xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN +xref: RHEA:13629 +xref: UM-BBD_reactionID:r0714 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018460 +name: cyclohexanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] +synonym: "cyclohexanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.245] +xref: EC:1.1.1.245 +xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN +xref: RHEA:10044 +xref: UM-BBD_reactionID:r0165 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018461 +name: fluoren-9-ol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] +synonym: "9-fluorenol dehydrogenase activity" EXACT [] +synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.256] +xref: EC:1.1.1.256 +xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN +xref: UM-BBD_reactionID:r0408 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018462 +name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24412] +synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.257] +synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] +synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] +xref: EC:1.1.1.257 +xref: KEGG_REACTION:R05271 +xref: MetaCyc:1.1.1.257-RXN +xref: RHEA:24412 +xref: UM-BBD_reactionID:r0291 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018463 +name: 6-hydroxyhexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14225] +synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.258] +xref: EC:1.1.1.258 +xref: KEGG_REACTION:R05283 +xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN +xref: RHEA:14225 +xref: UM-BBD_reactionID:r0174 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018464 +name: 3-hydroxypimeloyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11168] +synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.259] +xref: EC:1.1.1.259 +xref: KEGG_REACTION:R05305 +xref: MetaCyc:1.1.1.259-RXN +xref: RHEA:11168 +xref: UM-BBD_reactionID:r0196 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018465 +name: vanillyl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10036] +synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" RELATED [EC:1.1.3.38] +synonym: "vanillyl alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.38] +xref: EC:1.1.3.38 +xref: KEGG_REACTION:R02877 +xref: MetaCyc:1.1.3.38-RXN +xref: RHEA:10036 +xref: UM-BBD_reactionID:r0651 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0018466 +name: limonene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735] +xref: EC:1.1.99.- +xref: UM-BBD_reactionID:r0735 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0018467 +name: formaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16425] +synonym: "formaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.46] +synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] +xref: EC:1.2.1.46 +xref: KEGG_REACTION:R00604 +xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:16425 +xref: UM-BBD_reactionID:r0240 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0018469 +name: myrtenal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711] +xref: UM-BBD_reactionID:r0711 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018470 +name: 4-hydroxybutaraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014] +xref: UM-BBD_reactionID:r0014 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018471 +name: 4-chlorobenzaldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0447 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018472 +name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485] +xref: UM-BBD_reactionID:r0485 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018473 +name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744] +xref: UM-BBD_reactionID:r0744 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018474 +name: 2-carboxybenzaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490] +xref: EC:1.2.1.- +xref: UM-BBD_reactionID:r0490 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0018475 +name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745] +xref: UM-BBD_reactionID:r0745 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018477 +name: benzaldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] +synonym: "benzaldehyde:NADP+ oxidoreductase" RELATED [EC:1.2.1.7] +synonym: "NADP-linked benzaldehyde dehydrogenase" RELATED [EC:1.2.1.7] +xref: EC:1.2.1.7 +xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:21660 +xref: UM-BBD_enzymeID:e0079 +is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity +is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity + +[Term] +id: GO:0018478 +name: malonate-semialdehyde dehydrogenase (acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] +synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" RELATED [EC:1.2.1.18] +synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] +xref: EC:1.2.1.18 +xref: MetaCyc:1.2.1.18-RXN +xref: RHEA:22988 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018479 +name: benzaldehyde dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] +synonym: "benzaldehyde (NAD) dehydrogenase activity" RELATED [EC:1.2.1.28] +synonym: "benzaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.28] +xref: EC:1.2.1.28 +xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN +xref: RHEA:11840 +xref: UM-BBD_reactionID:r0269 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity +is_a: GO:0019115 ! benzaldehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0018480 +name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] +synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.60] +synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.60] +xref: EC:1.2.1.60 +xref: MetaCyc:CHMS-DEHYDROGENASE-RXN +xref: RHEA:15681 +xref: UM-BBD_reactionID:r0365 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018481 +name: 4-hydroxymuconic-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22420] +synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.61] +xref: EC:1.2.1.61 +xref: KEGG_REACTION:R05236 +xref: MetaCyc:1.2.1.61-RXN +xref: RHEA:22420 +xref: UM-BBD_reactionID:r0229 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018482 +name: 4-formylbenzenesulfonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18833] +synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.62] +synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] +synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] +xref: EC:1.2.1.62 +xref: KEGG_REACTION:R05272 +xref: MetaCyc:1.2.1.62-RXN +xref: RHEA:18833 +xref: UM-BBD_reactionID:r0292 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018483 +name: 6-oxohexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] +synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.63] +xref: EC:1.2.1.63 +xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN +xref: RHEA:13397 +xref: UM-BBD_reactionID:r0175 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018484 +name: 4-hydroxybenzaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] +synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.64] +synonym: "p-hydroxybenzaldehyde dehydrogenase activity" RELATED [EC:1.2.1.64] +xref: EC:1.2.1.64 +xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN +xref: RHEA:20305 +xref: UM-BBD_reactionID:r0273 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0018485 +name: salicylaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] +synonym: "salicylaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.65] +xref: EC:1.2.1.65 +xref: MetaCyc:1.2.1.65-RXN +xref: RHEA:18537 +xref: UM-BBD_enzymeID:e0256 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0018486 +name: 2-butanone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169] +xref: UM-BBD_reactionID:r0169 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0018487 +name: vanillate O-demethylase (anaerobic) activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758] +xref: UM-BBD_reactionID:r0758 +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0018488 +name: aryl-aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9] +synonym: "aryl-aldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.9] +xref: EC:1.2.3.9 +xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN +xref: RHEA:18569 +xref: UM-BBD_reactionID:r0145 +is_a: GO:0004031 ! aldehyde oxidase activity + +[Term] +id: GO:0018489 +name: vanillate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13021] +comment: Note that this was EC:1.2.3.12. +synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" RELATED [EC:1.14.13.82] +synonym: "vanillate demethylase (aerobic) activity" EXACT [] +synonym: "vanillate demethylase activity" EXACT [] +synonym: "vanillate:oxygen oxidoreductase (demethylating)" RELATED [EC:1.14.13.82] +xref: EC:1.14.13.82 +xref: KEGG_REACTION:R05274 +xref: MetaCyc:RXN-10891 +xref: MetaCyc:RXN-2 +xref: RHEA:13021 +xref: UM-BBD_reactionID:r0146 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0018490 +name: 4-hydroxyphenylpyruvate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17197] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] +xref: EC:1.2.3.13 +xref: KEGG_REACTION:R00042 +xref: MetaCyc:1.2.3.13-RXN +xref: RHEA:17197 +xref: UM-BBD_reactionID:r0299 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0018491 +name: 2-oxobutyrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [GOC:curators] +synonym: "2-ketobutyrate synthase activity" EXACT [] +synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [] +synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [] +synonym: "alpha-ketobutyrate synthase activity" EXACT [] +synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [] +xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN +xref: RHEA:32135 +xref: UM-BBD_reactionID:r0358 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018492 +name: carbon-monoxide dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.7.4] +synonym: "anaerobic carbon monoxide dehydrogenase activity" RELATED [EC:1.2.7.4] +synonym: "carbon monoxide dehydrogenase activity" BROAD [] +synonym: "carbon-monoxide:acceptor oxidoreductase activity" RELATED [EC:1.2.7.4] +xref: EC:1.2.7.4 +xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN +xref: RHEA:21040 +xref: UM-BBD_enzymeID:e0415 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018493 +name: formylmethanofuran dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.7.12, RHEA:19841] +synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" RELATED [EC:1.2.7.12] +synonym: "formylmethanofuran:acceptor oxidoreductase activity" RELATED [EC:1.2.7.12] +xref: EC:1.2.7.12 +xref: KEGG_REACTION:R03015 +xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN +xref: RHEA:19841 +xref: UM-BBD_reactionID:r0345 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0018494 +name: carvone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_reactionID:r0732] +xref: EC:1.3.99.25 +xref: MetaCyc:RXN-9403 +xref: MetaCyc:RXN-9419 +xref: UM-BBD_reactionID:r0732 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018495 +name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192] +xref: UM-BBD_reactionID:r0192 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018496 +name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205] +xref: UM-BBD_reactionID:r0205 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018497 +name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514] +synonym: "DDMS dehydrogenase activity" EXACT [] +xref: UM-BBD_reactionID:r0514 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018498 +name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] +xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN +xref: RHEA:25062 +xref: UM-BBD_enzymeID:e0308 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018499 +name: cis-2,3-dihydrodiol DDT dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451] +xref: UM-BBD_reactionID:r0451 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018500 +name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575] +xref: UM-BBD_reactionID:r0575 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018501 +name: cis-chlorobenzene dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411] +xref: UM-BBD_enzymeID:e0411 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018502 +name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553] +xref: MetaCyc:LINC-RXN +xref: RHEA:15741 +xref: UM-BBD_reactionID:r0553 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018503 +name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574] +xref: UM-BBD_reactionID:r0574 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018504 +name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] +synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.19] +synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" RELATED [EC:1.3.1.19] +synonym: "cis-benzene glycol dehydrogenase activity" RELATED [EC:1.3.1.19] +xref: EC:1.3.1.19 +xref: MetaCyc:1.3.1.19-RXN +xref: RHEA:15457 +xref: UM-BBD_enzymeID:e0060 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018505 +name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] +synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29] +synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] +synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" RELATED [EC:1.3.1.29] +synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" RELATED [EC:1.3.1.29] +synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29] +synonym: "naphthalene dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.29] +xref: EC:1.3.1.29 +xref: MetaCyc:1.3.1.29-RXN +xref: RHEA:11832 +xref: UM-BBD_enzymeID:e0122 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018506 +name: maleylacetate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] +synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.32] +synonym: "maleolylacetate reductase activity" RELATED [EC:1.3.1.32] +xref: EC:1.3.1.32 +xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN +xref: UM-BBD_enzymeID:e0063 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018507 +name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16253] +synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" RELATED [EC:1.3.1.49] +synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] +xref: EC:1.3.1.49 +xref: KEGG_REACTION:R04151 +xref: MetaCyc:1.3.1.49-RXN +xref: RHEA:16253 +xref: UM-BBD_reactionID:r0488 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018508 +name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] +synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] +xref: UM-BBD_enzymeID:e0219 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018509 +name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] +synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] +synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" RELATED [EC:1.3.1.56] +synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.56] +xref: EC:1.3.1.56 +xref: MetaCyc:1.3.1.56-RXN +xref: RHEA:17033 +xref: UM-BBD_enzymeID:e0134 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018510 +name: phloroglucinol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10080] +synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.57] +xref: EC:1.3.1.57 +xref: KEGG_REACTION:R05308 +xref: MetaCyc:R5-RXN +xref: RHEA:10080 +xref: UM-BBD_reactionID:r0007 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018511 +name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23772] +synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.58] +xref: EC:1.3.1.58 +xref: KEGG_REACTION:R05240 +xref: MetaCyc:RXN-665 +xref: RHEA:23772 +xref: UM-BBD_reactionID:r0396 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018512 +name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59] +comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists. +synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT [] +synonym: "1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity" EXACT [] +xref: UM-BBD_reactionID:r0216 +is_obsolete: true + +[Term] +id: GO:0018513 +name: dibenzothiophene dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24188] +synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.60] +xref: EC:1.3.1.60 +xref: KEGG_REACTION:R05310 +xref: MetaCyc:1.3.1.60-RXN +xref: RHEA:24188 +xref: UM-BBD_reactionID:r0161 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018515 +name: pimeloyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19665] +synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.62] +xref: EC:1.3.1.62 +xref: KEGG_REACTION:R05311 +xref: MetaCyc:1.3.1.62-RXN +xref: RHEA:19665 +xref: UM-BBD_reactionID:r0194 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018516 +name: 2,4-dichlorobenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23076] +synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" RELATED [EC:1.21.1.2] +xref: EC:1.21.1.2 +xref: KEGG_REACTION:R05276 +xref: MetaCyc:1.3.1.63-RXN +xref: RHEA:23076 +xref: UM-BBD_reactionID:r0138 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018517 +name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13837] +synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.64] +xref: EC:1.3.1.64 +xref: KEGG_REACTION:R05275 +xref: MetaCyc:1.3.1.64-RXN +xref: RHEA:13837 +xref: UM-BBD_reactionID:r0142 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018518 +name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24556] +synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] +synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.65] +xref: EC:1.3.1.65 +xref: KEGG_REACTION:R05312 +xref: MetaCyc:RXN-643 +xref: RHEA:24556 +xref: UM-BBD_reactionID:r0053 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018519 +name: cis-dihydroethylcatechol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18101] +synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.66] +synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] +xref: EC:1.3.1.66 +xref: KEGG_REACTION:R05313 +xref: MetaCyc:1.3.1.66-RXN +xref: RHEA:18101 +xref: UM-BBD_reactionID:r0309 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018520 +name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] +synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] +synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.67] +xref: EC:1.3.1.67 +xref: MetaCyc:1.3.1.67-RXN +xref: UM-BBD_reactionID:r0179 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018521 +name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15657] +synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.68] +xref: EC:1.3.1.68 +xref: KEGG_REACTION:R05314 +xref: MetaCyc:1.3.1.68-RXN +xref: RHEA:15657 +xref: UM-BBD_reactionID:r0224 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018522 +name: benzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8] +synonym: "benzoyl-CoA reductase (dearomatizing) activity" RELATED [EC:1.3.7.8] +synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity" EXACT [KEGG_REACTION:R02451] +xref: EC:1.3.7.8 +xref: KEGG_REACTION:R02451 +xref: MetaCyc:1.3.99.15-RXN +xref: RHEA:30199 +xref: UM-BBD_reactionID:r0190 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0018523 +name: quinoline 2-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] +synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.17] +xref: EC:1.3.99.17 +xref: MetaCyc:1.3.99.17-RXN +xref: RHEA:17749 +xref: UM-BBD_reactionID:r0045 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0018524 +name: acetophenone carboxylase activity +namespace: molecular_function +alt_id: GO:0018797 +def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033] +xref: EC:6.4.1.- +xref: UM-BBD_reactionID:r0033 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018525 +name: 4-hydroxybenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [RHEA:29603] +synonym: "4-hydroxybenzoyl-coA reductase (dehydroxylating) activity" RELATED [] +synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" RELATED [] +xref: EC:1.1.7.1 +xref: KEGG_REACTION:R05316 +xref: MetaCyc:OHBENZCOARED-RXN +xref: RHEA:29603 +xref: UM-BBD_reactionID:r0158 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0018526 +name: 2-aminobenzoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342] +xref: UM-BBD_reactionID:r0342 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0018527 +name: cyclohexylamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12] +synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.12] +xref: EC:1.4.3.12 +xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN +xref: RHEA:18433 +xref: UM-BBD_reactionID:r0754 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0018528 +name: iminodiacetate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589] +xref: UM-BBD_reactionID:r0589 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018529 +name: nitrilotriacetate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587] +xref: EC:1.14.14.10 +xref: UM-BBD_reactionID:r0587 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0018530 +name: (R)-6-hydroxynicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10012] +synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.6] +synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] +synonym: "D-6-hydroxynicotine oxidase activity" RELATED [EC:1.5.3.6] +xref: EC:1.5.3.6 +xref: KEGG_REACTION:R07170 +xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN +xref: RHEA:10012 +xref: UM-BBD_reactionID:r0477 +is_a: GO:0019116 ! hydroxy-nicotine oxidase activity + +[Term] +id: GO:0018531 +name: (S)-6-hydroxynicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11880] +synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.5] +synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] +synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.5] +synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] +xref: EC:1.5.3.5 +xref: KEGG_REACTION:R03202 +xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN +xref: RHEA:11880 +xref: UM-BBD_reactionID:r0478 +is_a: GO:0019116 ! hydroxy-nicotine oxidase activity + +[Term] +id: GO:0018532 +name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353] +synonym: "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] +synonym: "coenzyme F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] +synonym: "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] +synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] +xref: EC:1.5.99.- +xref: UM-BBD_reactionID:r0353 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018533 +name: peptidyl-cysteine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-cysteine." [GOC:mah] +is_a: GO:0006473 ! protein acetylation +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0018534 +name: nitrilotriacetate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588] +xref: EC:1.5.99.- +xref: UM-BBD_reactionID:r0588 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018535 +name: nicotine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] +synonym: "D-nicotine oxidase activity" RELATED [EC:1.5.99.4] +synonym: "nicotine oxidase activity" RELATED [EC:1.5.99.4] +synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" RELATED [EC:1.5.99.4] +synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" RELATED [EC:1.5.99.4] +xref: EC:1.5.99.4 +xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN +xref: RHEA:14769 +xref: UM-BBD_enzymeID:e0337 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018537 +name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.2, RHEA:21144] +synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" RELATED [EC:1.5.98.2] +synonym: "5,10-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2] +synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2] +synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2] +synonym: "methylene-H(4)MPT reductase activity" RELATED [EC:1.5.98.2] +synonym: "methylene-H4MPT reductase activity" RELATED [EC:1.5.98.2] +synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2] +synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" RELATED [EC:1.5.98.2] +synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.2] +xref: EC:1.5.98.2 +xref: KEGG_REACTION:R04464 +xref: MetaCyc:METHELENE-THMPT-OXI-RXN +xref: RHEA:21144 +xref: UM-BBD_reactionID:r0354 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0018538 +name: epoxide carboxylase activity +namespace: molecular_function +def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0018541 +name: p-benzoquinone reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23488] +synonym: "NADPH:p-benzoquinone oxidoreductase activity" RELATED [EC:1.6.5.6] +xref: EC:1.6.5.6 +xref: KEGG_REACTION:R05244 +xref: MetaCyc:1.6.5.6-RXN +xref: RHEA:23488 +xref: UM-BBD_enzymeID:e0422 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0018542 +name: 2,3-dihydroxy DDT 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0452 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018543 +name: 4-amino-2-nitroso-6-nitrotoluene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464] +xref: UM-BBD_reactionID:r0464 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0018544 +name: 4-carboxy-4'-sulfoazobenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543] +synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] +xref: UM-BBD_reactionID:r0543 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0018545 +name: NAD(P)H nitroreductase activity +namespace: molecular_function +def: "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346] +xref: UM-BBD_enzymeID:e0346 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0018546 +name: nitrobenzene nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815] +xref: MetaCyc:RXN-8815 +xref: RHEA:52884 +xref: UM-BBD_enzymeID:e0245 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0018547 +name: nitroglycerin reductase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] +synonym: "NG reductase activity" EXACT [] +xref: UM-BBD_enzymeID:e0038 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0018548 +name: pentaerythritol trinitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025] +synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] +xref: EC:1.6.99.1 +xref: UM-BBD_reactionID:r0025 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0018549 +name: methanethiol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4] +synonym: "(MM)-oxidase activity" RELATED [EC:1.8.3.4] +synonym: "methanethiol:oxygen oxidoreductase activity" RELATED [EC:1.8.3.4] +synonym: "methyl mercaptan oxidase activity" RELATED [EC:1.8.3.4] +synonym: "methylmercaptan oxidase activity" RELATED [EC:1.8.3.4] +synonym: "MT-oxidase activity" RELATED [EC:1.8.3.4] +xref: EC:1.8.3.4 +xref: MetaCyc:METHANETHIOL-OXIDASE-RXN +xref: RHEA:11812 +xref: UM-BBD_reactionID:r0209 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0018550 +name: tetrachloro-p-hydroquinone reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314] +synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT [] +xref: EC:1.8.99.- +xref: UM-BBD_reactionID:r0314 +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0018551 +name: hydrogensulfite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3] +synonym: "bisulfite reductase activity" RELATED [EC:1.8.99.3] +synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] +synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] +synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] +synonym: "dissimilatory sulfite reductase activity" EXACT [] +synonym: "dissimilatory-type sulfite reductase activity" RELATED [EC:1.8.99.3] +synonym: "hydrogensulphite reductase activity" EXACT [] +synonym: "trithionate:(acceptor) oxidoreductase activity" RELATED [EC:1.8.99.3] +synonym: "trithionate:acceptor oxidoreductase activity" RELATED [EC:1.8.99.3] +xref: EC:1.8.99.3 +xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN +xref: RHEA:13209 +xref: UM-BBD_reactionID:r0627 +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0018553 +name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] +xref: UM-BBD_enzymeID:e0309 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018554 +name: 1,2-dihydroxynaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] +xref: EC:1.13.11.56 +xref: RHEA:27310 +xref: UM-BBD_enzymeID:e0255 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018555 +name: phenanthrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0455 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018556 +name: 2,2',3-trihydroxybiphenyl dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0032 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018557 +name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0422 +is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity + +[Term] +id: GO:0018558 +name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0049 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018559 +name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442] +synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0442 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018560 +name: protocatechuate 3,4-dioxygenase type II activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0581 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018561 +name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0457 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018562 +name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0415 +is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity + +[Term] +id: GO:0018563 +name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0310 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018564 +name: carbazole 1,9a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456] +synonym: "carbazole 1,9alpha-dioxygenase activity" EXACT [] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0456 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018565 +name: dihydroxydibenzothiophene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0162 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018566 +name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324] +synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0324 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018567 +name: styrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0256 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018568 +name: 3,4-dihydroxyphenanthrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0501 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018569 +name: hydroquinone 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0228 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018570 +name: p-cumate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [RHEA:42344] +xref: EC:1.14.12.25 +xref: MetaCyc:RXN-664 +xref: RHEA:42344 +xref: UM-BBD_reactionID:r0395 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018571 +name: 2,3-dihydroxy-p-cumate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [RHEA:42568] +synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] +synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] +xref: MetaCyc:RXN-666 +xref: RHEA:42568 +xref: UM-BBD_reactionID:r0397 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018572 +name: 3,5-dichlorocatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0276 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018573 +name: 2-aminophenol 1,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0305 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018574 +name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] +xref: EC:1.13.11.- +xref: UM-BBD_enzymeID:e0422 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018575 +name: chlorocatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0655 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018576 +name: catechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] +synonym: "1,2-pyrocatechase activity" RELATED [EC:1.13.11.1] +synonym: "catechase activity" RELATED [EC:1.13.11.1] +synonym: "catechol 1,2-oxygenase activity" RELATED [EC:1.13.11.1] +synonym: "catechol-oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.1] +synonym: "catechol:oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.1] +synonym: "CD I" RELATED [EC:1.13.11.1] +synonym: "CD II" RELATED [EC:1.13.11.1] +synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] +synonym: "pyrocatechol 1,2-dioxygenase activity" RELATED [EC:1.13.11.1] +xref: EC:1.13.11.1 +xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN +xref: RHEA:23852 +xref: UM-BBD_enzymeID:e0064 +is_a: GO:0019114 ! catechol dioxygenase activity + +[Term] +id: GO:0018577 +name: catechol 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] +synonym: "2,3-pyrocatechase activity" RELATED [EC:1.13.11.2] +synonym: "catechol 2,3-oxygenase" RELATED [EC:1.13.11.2] +synonym: "catechol oxygenase" RELATED [EC:1.13.11.2] +synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.2] +synonym: "cato2ase activity" RELATED [EC:1.13.11.2] +synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] +synonym: "pyrocatechol 2,3-dioxygenase" RELATED [EC:1.13.11.2] +xref: EC:1.13.11.2 +xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN +xref: RHEA:17337 +xref: UM-BBD_enzymeID:e0156 +is_a: GO:0019114 ! catechol dioxygenase activity + +[Term] +id: GO:0018578 +name: protocatechuate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] +synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] +synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.3] +synonym: "protocatechuic 3,4-dioxygenase activity" RELATED [EC:1.13.11.3] +synonym: "protocatechuic 3,4-oxygenase activity" RELATED [EC:1.13.11.3] +synonym: "protocatechuic acid oxidase activity" RELATED [EC:1.13.11.3] +xref: EC:1.13.11.3 +xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN +xref: RHEA:10084 +xref: UM-BBD_reactionID:r0143 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018579 +name: protocatechuate 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] +synonym: "protocatechuate 4,5-oxygenase activity" RELATED [EC:1.13.11.8] +synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.8] +synonym: "protocatechuic 4,5-dioxygenase activity" RELATED [EC:1.13.11.8] +synonym: "protocatechuic 4,5-oxygenase activity" RELATED [EC:1.13.11.8] +xref: EC:1.13.11.8 +xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN +xref: RHEA:24044 +xref: UM-BBD_reactionID:r0144 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018580 +name: nitronate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28767] +comment: Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'. +synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.11.32] +synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16] +xref: EC:1.13.12.16 +xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN +xref: RHEA:28767 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0018581 +name: hydroxyquinol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] +synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.37] +synonym: "hydroxyquinol dioxygenase activity" RELATED [EC:1.13.11.37] +xref: EC:1.13.11.37 +xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN +xref: RHEA:19441 +xref: UM-BBD_reactionID:r0232 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018582 +name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] +synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.38] +synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" RELATED [EC:1.13.11.38] +xref: EC:1.13.11.38 +xref: MetaCyc:1.13.11.38-RXN +xref: RHEA:14749 +xref: UM-BBD_reactionID:r0486 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018583 +name: biphenyl-2,3-diol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] +synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] +synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] +synonym: "biphenyl-2,3-diol dioxygenase activity" RELATED [EC:1.13.11.39] +synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.39] +xref: EC:1.13.11.39 +xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN +xref: RHEA:14413 +xref: UM-BBD_enzymeID:e0127 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0018584 +name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359] +xref: EC:1.13.99.- +xref: UM-BBD_reactionID:r0359 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0018585 +name: fluorene oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407] +xref: UM-BBD_reactionID:r0407 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018586 +name: mono-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647] +synonym: "MBT dioxygenase activity" EXACT [] +xref: UM-BBD_reactionID:r0647 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018587 +name: obsolete limonene 8-monooxygenase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "limonene 8-monooxygenase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0019113 + +[Term] +id: GO:0018588 +name: tri-n-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643] +synonym: "TBT dioxygenase activity" EXACT [] +xref: UM-BBD_reactionID:r0643 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018589 +name: di-n-butyltin dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645] +synonym: "DBT dioxygenase activity" EXACT [] +xref: UM-BBD_reactionID:r0645 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018590 +name: methylsilanetriol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640] +xref: UM-BBD_reactionID:r0640 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018591 +name: methyl tertiary butyl ether 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] +synonym: "MTBE 3-monooxygenase activity" EXACT [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018592 +name: 4-nitrocatechol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231] +xref: EC:1.14.13.166 +xref: UM-BBD_reactionID:r0231 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018593 +name: 4-chlorophenoxyacetate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281] +xref: UM-BBD_reactionID:r0281 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018594 +name: tert-butanol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] +synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT [] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018595 +name: alpha-pinene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716] +xref: EC:1.14.13.155 +xref: RHEA:32891 +xref: UM-BBD_reactionID:r0716 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018596 +name: dimethylsilanediol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637] +synonym: "DMSD hydroxylase activity" EXACT [] +xref: UM-BBD_reactionID:r0637 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018597 +name: ammonia monooxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810] +xref: EC:1.14.99.39 +xref: RHEA:27341 +xref: UM-BBD_enzymeID:e0061 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018598 +name: hydroxymethylsilanetriol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641] +xref: UM-BBD_reactionID:r0641 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018599 +name: 2-hydroxyisobutyrate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619] +xref: UM-BBD_reactionID:r0619 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018600 +name: alpha-pinene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709] +xref: EC:1.14.-.- +xref: UM-BBD_reactionID:r0709 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018601 +name: 4-nitrophenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12568] +synonym: "4-nitrophenol hydroxylase activity" RELATED [EC:1.14.13.29] +synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.29] +synonym: "4-nitrophenol-2-hydroxylase activity" RELATED [EC:1.14.13.29] +xref: EC:1.14.13.29 +xref: KEGG_REACTION:R03023 +xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN +xref: RHEA:12568 +xref: UM-BBD_reactionID:r0230 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018602 +name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274] +xref: MetaCyc:RXN-9863 +xref: RHEA:48984 +xref: UM-BBD_reactionID:r0274 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0018603 +name: nitrobenzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0306 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018604 +name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0566 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018606 +name: benzenesulfonate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295] +synonym: "benzenesulphonate dioxygenase activity" EXACT [] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0295 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018607 +name: 1-indanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0417 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018608 +name: 1-indanone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0416 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018609 +name: chlorobenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0062 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018610 +name: dibenzofuran 4,4a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN, RHEA:42460] +xref: MetaCyc:R606-RXN +xref: RHEA:42460 +xref: UM-BBD_enzymeID:e0030 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018611 +name: toluate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] +xref: EC:1.14.12.- +xref: UM-BBD_enzymeID:e0190 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018612 +name: dibenzothiophene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0160 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018613 +name: 9-fluorenone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0409 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018614 +name: ethylbenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0247 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018615 +name: 2-indanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0424 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018616 +name: trihydroxytoluene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [PMID:1254564, UM-BBD_reactionID:r0093] +xref: MetaCyc:R305-RXN +xref: UM-BBD_reactionID:r0093 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018617 +name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580] +synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0580 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018618 +name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] +synonym: "AntA" RELATED [] +synonym: "AntB" RELATED [] +synonym: "AntC" RELATED [] +synonym: "anthranilate 1,2-dioxygenase" RELATED [] +synonym: "anthranilate dioxygenase activity" EXACT [] +synonym: "anthranilate dioxygenase reductase" NARROW [] +synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] +synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" RELATED [EC:1.14.12.1] +synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] +synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] +xref: EC:1.14.12.1 +xref: MetaCyc:1.14.12.1-RXN +xref: UM-BBD_reactionID:r0577 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018619 +name: benzene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13813] +synonym: "benzene dioxygenase activity" RELATED [EC:1.14.12.3] +synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] +synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.3] +xref: EC:1.14.12.3 +xref: KEGG_REACTION:R03543 +xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN +xref: RHEA:13813 +xref: UM-BBD_reactionID:r0079 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018620 +name: phthalate 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17489] +synonym: "PDO activity" RELATED [EC:1.14.12.7] +synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] +synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" RELATED [EC:1.14.12.7] +xref: EC:1.14.12.7 +xref: KEGG_REACTION:R03630 +xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN +xref: RHEA:17489 +xref: UM-BBD_reactionID:r0102 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018621 +name: 4-sulfobenzoate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13937] +synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] +synonym: "4-sulfobenzoate dioxygenase activity" RELATED [EC:1.14.12.8] +synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" RELATED [EC:1.14.12.8] +synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] +xref: EC:1.14.12.8 +xref: KEGG_REACTION:R01636 +xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN +xref: RHEA:13937 +xref: UM-BBD_reactionID:r0293 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018622 +name: 4-chlorophenylacetate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14689] +synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" RELATED [EC:1.14.12.9] +xref: EC:1.14.12.9 +xref: KEGG_REACTION:R03306 +xref: MetaCyc:1.14.12.9-RXN +xref: RHEA:14689 +xref: UM-BBD_reactionID:r0308 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018623 +name: benzoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] +synonym: "benzoate dioxygenase activity" RELATED [EC:1.14.12.10] +synonym: "benzoate hydroxylase activity" RELATED [EC:1.14.12.10] +synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.10] +synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" RELATED [EC:1.14.12.10] +synonym: "benzoic hydroxylase activity" RELATED [EC:1.14.12.10] +xref: EC:1.14.12.10 +xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN +xref: RHEA:12633 +xref: UM-BBD_enzymeID:e0154 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018624 +name: toluene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16737] +synonym: "toluene 1,2-dioxygenase activity" RELATED [EC:1.14.12.11] +synonym: "toluene 2,3-dioxygenase activity" RELATED [EC:1.14.12.11] +synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.11] +xref: EC:1.14.12.11 +xref: KEGG_REACTION:R03559 +xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN +xref: RHEA:16737 +xref: UM-BBD_enzymeID:e0155 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018625 +name: naphthalene 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] +synonym: "naphthalene dioxygenase activity" RELATED [EC:1.14.12.12] +synonym: "naphthalene oxygenase activity" RELATED [EC:1.14.12.12] +synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.12] +xref: EC:1.14.12.12 +xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN +xref: RHEA:19173 +xref: UM-BBD_enzymeID:e0002 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018626 +name: 2-chlorobenzoate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] +synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" RELATED [EC:1.14.12.13] +synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] +xref: EC:1.14.12.13 +xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN +xref: RHEA:21652 +xref: UM-BBD_reactionID:r0632 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018627 +name: 2-aminobenzenesulfonate 2,3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0018605 +def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23468] +synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT [] +synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" RELATED [EC:1.14.12.14] +synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] +synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] +synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" RELATED [EC:1.14.12.14] +xref: EC:1.14.12.14 +xref: KEGG_REACTION:R05156 +xref: MetaCyc:2ASDOSALCAL-RXN +xref: RHEA:23468 +xref: UM-BBD_reactionID:r0218 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018628 +name: terephthalate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10312] +synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" RELATED [EC:1.14.12.15] +synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" RELATED [EC:1.14.12.15] +synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" RELATED [EC:1.14.12.15] +xref: EC:1.14.12.15 +xref: KEGG_REACTION:R05148 +xref: MetaCyc:1.14.12.15-RXN +xref: RHEA:10312 +xref: UM-BBD_reactionID:r0150 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018629 +name: 2-hydroxyquinoline 5,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] +synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] +synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" RELATED [EC:1.14.12.16] +synonym: "quinolin-2-ol 5,6-dioxygenase activity" RELATED [EC:1.14.12.16] +synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" RELATED [EC:1.14.12.16] +xref: EC:1.14.12.16 +xref: MetaCyc:1.14.12.16-RXN +xref: RHEA:10976 +xref: UM-BBD_reactionID:r0052 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018630 +name: 3,5-xylenol methylhydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081] +xref: EC:1.14.13.- +xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN +xref: UM-BBD_reactionID:r0081 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018631 +name: phenylacetate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0036 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018632 +name: 4-nitrophenol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [RHEA:34327] +xref: EC:1.14.13.167 +xref: MetaCyc:RXN-8739 +xref: RHEA:34327 +xref: UM-BBD_reactionID:r0226 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018633 +name: dimethyl sulfide monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208] +synonym: "dimethyl sulphide monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0208 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018634 +name: alpha-pinene monooxygenase [NADH] activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0742 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018635 +name: (R)-limonene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] +synonym: "(+)-limonene 1,2-monooxygenase activity" RELATED [EC:1.14.13.107] +synonym: "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] +synonym: "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] +xref: EC:1.14.13.107 +xref: KEGG_REACTION:R06398 "limonene,NADH:oxygen oxidoreductase" +xref: KEGG_REACTION:R09393 "limonene,NADPH:oxygen oxidoreductase" +xref: MetaCyc:RXN-9407 +xref: UM-BBD_reactionID:r0733 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018636 +name: phenanthrene 9,10-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0495 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018637 +name: 1-hydroxy-2-naphthoate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0491 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018638 +name: toluene 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0225 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018639 +name: xylene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0172 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018640 +name: dibenzothiophene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [RHEA:49076] +xref: MetaCyc:RXN-621 +xref: RHEA:49076 +xref: UM-BBD_enzymeID:e0214 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018641 +name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0048 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018642 +name: chlorophenol 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0252 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018643 +name: carbon disulfide oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599] +synonym: "carbon disulphide oxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0599 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018644 +name: toluene 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [RHEA:20349] +xref: EC:1.14.13.243 +xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN +xref: RHEA:20349 +xref: UM-BBD_enzymeID:e0222 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018645 +name: alkene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] +synonym: "alkene epoxygenase activity" RELATED [EC:1.14.13.69] +synonym: "alkene,NADH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.69] +xref: EC:1.14.13.69 +xref: MetaCyc:1.14.13.69-RXN +xref: RHEA:11792 +xref: UM-BBD_enzymeID:e0039 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018646 +name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0736 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018647 +name: phenanthrene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] +xref: EC:1.14.13.- +xref: UM-BBD_enzymeID:e0333 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018648 +name: methanesulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111] +synonym: "mesylate monooxygenase activity" RELATED [EC:1.14.13.111] +synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" RELATED [EC:1.14.13.111] +synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111] +synonym: "methanesulfonic acid monooxygenase activity" RELATED [EC:1.14.13.111] +synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah] +synonym: "MSA monooxygenase activity" RELATED [EC:1.14.13.111] +synonym: "MSAMO activity" RELATED [EC:1.14.13.111] +xref: EC:1.14.13.111 +xref: MetaCyc:RXN-9770 +xref: RHEA:26077 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018649 +name: tetrahydrofuran hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0017 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018650 +name: styrene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0225 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018651 +name: toluene-4-sulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296] +synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0296 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018652 +name: toluene-sulfonate methyl-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [RHEA:51024] +synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] +xref: MetaCyc:TSMOS-RXN +xref: RHEA:51024 +xref: UM-BBD_reactionID:r0290 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018653 +name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0046 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018654 +name: 2-hydroxy-phenylacetate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0252 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018655 +name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0430 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018656 +name: phenanthrene 3,4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0508 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018657 +name: toluene 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] +xref: EC:1.14.13.- +xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN +xref: UM-BBD_enzymeID:e0224 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018658 +name: salicylate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] +synonym: "salicylate 1-hydroxylase activity" RELATED [EC:1.14.13.1] +synonym: "salicylate hydroxylase (decarboxylating)" RELATED [EC:1.14.13.1] +synonym: "salicylate hydroxylase activity" EXACT [] +synonym: "salicylate monooxygenase activity" RELATED [EC:1.14.13.1] +synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.1] +synonym: "salicylic hydroxylase activity" RELATED [EC:1.14.13.1] +xref: EC:1.14.13.1 +xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN +xref: RHEA:11004 +xref: UM-BBD_enzymeID:e0149 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018659 +name: 4-hydroxybenzoate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] +synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "4-hydroxybenzoate monooxygenase activity" RELATED [EC:1.14.13.2] +synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.2] +synonym: "p-hydroxybenzoate hydrolyase activity" RELATED [EC:1.14.13.2] +synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "p-hydroxybenzoate-3-hydroxylase activity" RELATED [EC:1.14.13.2] +synonym: "p-hydroxybenzoic acid hydrolase activity" RELATED [EC:1.14.13.2] +synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] +synonym: "p-hydroxybenzoic hydroxylase activity" RELATED [EC:1.14.13.2] +synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] +xref: EC:1.14.13.2 +xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN +xref: UM-BBD_reactionID:r0109 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018660 +name: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [RHEA:16681] +synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.14.9] +synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" BROAD [] +synonym: "4-hydroxyphenylacetate 3-monooxygenase activity" BROAD [] +synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.14.9] +synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.14.9] +xref: EC:1.14.14.9 +xref: KEGG_REACTION:R02698 +xref: RHEA:16681 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018661 +name: orcinol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19601] +synonym: "orcinol hydroxylase activity" EXACT [] +synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.6] +xref: EC:1.14.13.6 +xref: KEGG_REACTION:R02830 +xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN +xref: RHEA:19601 +xref: UM-BBD_reactionID:r0092 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018662 +name: phenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] +synonym: "phenol hydroxylase activity" RELATED [EC:1.14.13.7] +synonym: "phenol o-hydroxylase activity" RELATED [EC:1.14.13.7] +synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.7] +xref: EC:1.14.13.7 +xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN +xref: RHEA:17061 +xref: UM-BBD_enzymeID:e0208 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018663 +name: 2,6-dihydroxypyridine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16917] +synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] +synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.10] +xref: EC:1.14.13.10 +xref: KEGG_REACTION:R04130 +xref: MetaCyc:1.14.13.10-RXN +xref: RHEA:16917 +xref: UM-BBD_reactionID:r0479 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018664 +name: benzoate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.14.92, RHEA:18033] +synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] +synonym: "benzoate 4-hydroxylase activity" RELATED [EC:1.14.14.92] +synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.14.92] +synonym: "benzoate-p-hydroxylase activity" RELATED [EC:1.14.14.92] +synonym: "benzoate-para-hydroxylase activity" RELATED [EC:1.14.14.92] +synonym: "benzoic 4-hydroxylase activity" RELATED [EC:1.14.14.92] +synonym: "benzoic acid 4-hydroxylase activity" RELATED [EC:1.14.14.92] +synonym: "p-hydroxybenzoate hydroxylase activity" RELATED [EC:1.14.14.92] +xref: EC:1.14.14.92 +xref: KEGG_REACTION:R01295 +xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN +xref: RHEA:18033 +xref: UM-BBD_reactionID:r0623 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018665 +name: 4-hydroxyphenylacetate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] +synonym: "4-HPA 1-hydroxylase activity" RELATED [EC:1.14.13.18] +synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] +synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" RELATED [EC:1.14.13.18] +synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" RELATED [EC:1.14.13.18] +synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" RELATED [EC:1.14.13.18] +xref: EC:1.14.13.18 +xref: MetaCyc:1.14.13.18-RXN +xref: UM-BBD_reactionID:r0300 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018666 +name: 2,4-dichlorophenol 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] +synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] +synonym: "2,4-dichlorophenol monooxygenase activity" RELATED [EC:1.14.13.20] +synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.20] +xref: EC:1.14.13.20 +xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN +xref: RHEA:20920 +xref: UM-BBD_enzymeID:e0152 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018667 +name: cyclohexanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] +synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] +synonym: "cyclohexanone oxygenase activity" RELATED [EC:1.14.13.22] +synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" RELATED [EC:1.14.13.22] +synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" RELATED [EC:1.14.13.22] +xref: EC:1.14.13.22 +xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN +xref: RHEA:24068 +xref: UM-BBD_reactionID:r0166 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018668 +name: 3-hydroxybenzoate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11480] +synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.13.23] +xref: EC:1.14.13.23 +xref: KEGG_REACTION:R01628 +xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN +xref: RHEA:11480 +xref: UM-BBD_reactionID:r0153 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018669 +name: 3-hydroxybenzoate 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22692] +synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.24] +synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" RELATED [EC:1.14.13.24] +synonym: "m-hydroxybenzoate 6-hydroxylase activity" RELATED [EC:1.14.13.24] +xref: EC:1.14.13.24 +xref: KEGG_REACTION:R02589 +xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN +xref: RHEA:22692 +xref: UM-BBD_reactionID:r0402 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018670 +name: 4-aminobenzoate 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] +synonym: "4-aminobenzoate dehydrogenase activity" RELATED [EC:1.14.13.27] +synonym: "4-aminobenzoate hydroxylase activity" EXACT [] +synonym: "4-aminobenzoate monooxygenase activity" RELATED [EC:1.14.13.27] +synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.27] +xref: EC:1.14.13.27 +xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN +xref: UM-BBD_reactionID:r0597 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018671 +name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] +synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] +synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] +synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.33] +synonym: "4-hydroxybenzoate-3-hydroxylase activity" RELATED [EC:1.14.13.33] +xref: EC:1.14.13.33 +xref: MetaCyc:1.14.13.33-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018672 +name: anthranilate 3-monooxygenase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21236] +synonym: "anthranilate 2,3-dioxygenase (deaminating)" RELATED [EC:1.14.13.35] +synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" RELATED [EC:1.14.13.35] +synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] +synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] +synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" RELATED [EC:1.14.13.35] +xref: EC:1.14.13.35 +xref: KEGG_REACTION:R00980 +xref: MetaCyc:1.14.13.35-RXN +xref: RHEA:21236 +xref: UM-BBD_reactionID:r0578 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018673 +name: anthraniloyl-CoA monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] +synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" RELATED [EC:1.14.13.40] +synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" RELATED [EC:1.14.13.40] +synonym: "anthraniloyl coenzyme A reductase activity" RELATED [EC:1.14.13.40] +xref: EC:1.14.13.40 +xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN +xref: UM-BBD_reactionID:r0568 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018674 +name: (S)-limonene 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.14.99, RHEA:15129] +synonym: "(-)-limonene 3-hydroxylase activity" RELATED [EC:1.14.14.99] +synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] +synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.14.99] +synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.14.99] +synonym: "limonene 3-hydroxylase activity" EXACT [] +xref: EC:1.14.14.99 +xref: KEGG_REACTION:R02469 +xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN +xref: RHEA:15129 +xref: UM-BBD_reactionID:r0739 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018675 +name: (S)-limonene 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.14.51] +synonym: "(-)-limonene 6-hydroxylase activity" RELATED [EC:1.14.14.51] +synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] +synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" RELATED [EC:1.14.14.51] +synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.14.51] +synonym: "limonene 6-hydroxylase activity" EXACT [] +xref: EC:1.14.14.51 +xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN +xref: RHEA:17945 +xref: UM-BBD_reactionID:r0713 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018676 +name: (S)-limonene 7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.14.52, RHEA:23432] +synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] +xref: EC:1.14.14.52 +xref: KEGG_REACTION:R02470 +xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN +xref: RHEA:23432 +xref: UM-BBD_reactionID:r0728 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0018677 +name: pentachlorophenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] +synonym: "PCB 4-monooxygenase activity" RELATED [EC:1.14.13.50] +synonym: "PCB4MO activity" RELATED [EC:1.14.13.50] +synonym: "PCP hydroxylase activity" RELATED [EC:1.14.13.50] +synonym: "PcpB" RELATED [EC:1.14.13.50] +synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] +synonym: "pentachlorophenol dechlorinase activity" RELATED [EC:1.14.13.50] +synonym: "pentachlorophenol dehalogenase activity" RELATED [EC:1.14.13.50] +synonym: "pentachlorophenol hydroxylase activity" EXACT [] +synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" RELATED [EC:1.14.13.50] +xref: EC:1.14.13.50 +xref: MetaCyc:PCP4MONO-RXN +xref: RHEA:18685 +xref: UM-BBD_enzymeID:e0148 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018678 +name: 4-hydroxybenzoate 1-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] +synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] +synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" RELATED [EC:1.14.13.64] +xref: EC:1.14.13.64 +xref: MetaCyc:1.14.13.64-RXN +xref: UM-BBD_reactionID:r0752 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018679 +name: dibenzothiophene-5,5-dioxide monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235] +xref: EC:1.14.14.- +xref: MetaCyc:RXN-623 +xref: UM-BBD_reactionID:r0235 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018680 +name: deethylatrazine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128] +xref: EC:1.14.15.- +xref: UM-BBD_reactionID:r0128 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018681 +name: deisopropylatrazine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG_REACTION:R05567] +xref: EC:1.14.15.- +xref: KEGG_REACTION:R05567 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018682 +name: atrazine N-dealkylase activity +namespace: molecular_function +def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127] +synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090] +xref: EC:1.14.15.- +xref: MetaCyc:R461-RXN +xref: UM-BBD_reactionID:r0127 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018683 +name: camphor 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] +synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.15.1] +synonym: "2-bornanone 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "bornanone 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "camphor 5-exo-hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] +synonym: "camphor 5-exohydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "camphor hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "camphor methylene hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "cytochrome p450-cam activity" RELATED [EC:1.14.15.1] +synonym: "d-camphor monooxygenase activity" RELATED [EC:1.14.15.1] +synonym: "D-camphor-exo-hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "methylene hydroxylase activity" RELATED [EC:1.14.15.1] +synonym: "methylene monooxygenase activity" RELATED [EC:1.14.15.1] +xref: EC:1.14.15.1 +xref: MetaCyc:R541-RXN +xref: RHEA:13525 +xref: UM-BBD_enzymeID:e0300 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018684 +name: 2,5-diketocamphane 1,2-monooxygenase +namespace: molecular_function +def: "Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O." [PMID:3944058, PMID:8515237, RHEA:34415] +comment: Formerly EC:1.14.15.2. +synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" RELATED [] +synonym: "2,5-diketocamphane lactonizing enzyme activity" RELATED [EC:1.14.14.108] +synonym: "camphor 1,2-monooxygenase activity" EXACT [] +synonym: "camphor ketolactonase I activity" RELATED [EC:1.14.14.108] +xref: EC:1.14.14.108 +xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN +xref: RHEA:34415 +xref: UM-BBD_enzymeID:e0302 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018685 +name: alkane 1-monooxygenase activity +namespace: molecular_function +alt_id: GO:0008393 +def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] +synonym: "1-hydroxylase activity" RELATED [EC:1.14.15.3] +synonym: "alkane 1-hydroxylase activity" EXACT [] +synonym: "alkane hydroxylase activity" RELATED [EC:1.14.15.3] +synonym: "alkane monooxygenase activity" RELATED [EC:1.14.15.3] +synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" RELATED [EC:1.14.15.3] +synonym: "fatty acid (omega-1)-hydroxylase activity" EXACT [] +synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] +synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] +synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] +xref: EC:1.14.15.3 +xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN +xref: RHEA:19341 +xref: UM-BBD_enzymeID:e0022 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018686 +name: 6-hydroxy pseudo-oxynicotine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480] +xref: EC:1.14.18.- +xref: UM-BBD_reactionID:r0480 +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0018687 +name: biphenyl 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18] +synonym: "biphenyl dioxygenase activity" RELATED [EC:1.14.12.18] +synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" RELATED [EC:1.14.12.18] +xref: EC:1.14.12.18 +xref: MetaCyc:1.14.12.18-RXN +xref: RHEA:18165 +xref: UM-BBD_enzymeID:e0089 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0018688 +name: DDT 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450] +xref: UM-BBD_reactionID:r0450 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0018689 +name: naphthalene disulfonate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] +synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] +xref: UM-BBD_enzymeID:e0249 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018690 +name: 4-methoxybenzoate monooxygenase (O-demethylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18613] +synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" RELATED [EC:1.14.99.15] +synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] +synonym: "4-methoxybenzoate O-demethylase activity" RELATED [EC:1.14.99.15] +synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" RELATED [EC:1.14.99.15] +synonym: "p-anisic O-demethylase activity" RELATED [EC:1.14.99.15] +synonym: "piperonylate-4-O-demethylase activity" RELATED [EC:1.14.99.15] +xref: EC:1.14.99.15 +xref: KEGG_REACTION:R01306 +xref: MetaCyc:1.14.99.15-RXN +xref: RHEA:18613 +xref: UM-BBD_reactionID:r0154 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0018693 +name: ethylbenzene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17897] +synonym: "ethylbenzene dehydrogenase activity" RELATED [EC:1.17.99.2] +synonym: "ethylbenzene:(acceptor) oxidoreductase activity" RELATED [EC:1.17.99.2] +xref: EC:1.17.99.2 +xref: KEGG_REACTION:R05745 +xref: MetaCyc:RXN-1301 +xref: RHEA:17897 +xref: UM-BBD_reactionID:r0234 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018694 +name: p-cymene methyl hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [RHEA:51604] +xref: EC:1.14.15.25 +xref: MetaCyc:RXN-661 +xref: RHEA:51604 +xref: UM-BBD_reactionID:r0392 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018695 +name: 4-cresol dehydrogenase (hydroxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.9.1] +synonym: "4-cresol dehydrogenase activity" EXACT [] +synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" RELATED [EC:1.17.9.1] +synonym: "p-cresol methylhydroxylase activity" RELATED [EC:1.17.9.1] +synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" RELATED [EC:1.17.9.1] +xref: EC:1.17.9.1 +xref: MetaCyc:1.17.99.1-RXN +xref: RHEA:15141 +xref: UM-BBD_reactionID:r0272 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0018697 +name: carbonyl sulfide nitrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600] +synonym: "carbonyl sulphide nitrogenase activity" EXACT [] +xref: EC:1.18.6.1 +xref: UM-BBD_reactionID:r0600 +is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor + +[Term] +id: GO:0018698 +name: vinyl chloride reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene." [UM-BBD_reactionID:r0352] +xref: EC:1.97.1.- +xref: MetaCyc:VCREDCHLOR-RXN +xref: UM-BBD_reactionID:r0352 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018699 +name: 1,1,1-trichloroethane reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r1007 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018700 +name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0719 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018701 +name: 2,5-dichlorohydroquinone reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] +xref: EC:1.97.1.- +xref: UM-BBD_enzymeID:e0366 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018702 +name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440] +synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] +synonym: "DDE dehalogenase activity" EXACT [] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0440 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018703 +name: 2,4-dichlorophenoxyacetate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280] +xref: UM-BBD_reactionID:r0280 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018704 +name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018705 +name: 1,2-dichloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] +synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] +xref: UM-BBD_enzymeID:e0272 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018706 +name: pyrogallol hydroxytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" RELATED [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" RELATED [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" RELATED [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" RELATED [EC:1.97.1.2] +synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" RELATED [EC:1.97.1.2] +synonym: "pyrogallol hydroxyltransferase activity" EXACT [] +synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] +xref: EC:1.97.1.2 +xref: MetaCyc:1.97.1.2-RXN +xref: RHEA:21000 +xref: UM-BBD_reactionID:r0006 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0018707 +name: 1-phenanthrol methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493] +xref: UM-BBD_reactionID:r0493 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0018708 +name: thiol S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] +synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" RELATED [EC:2.1.1.9] +synonym: "thiol methyltransferase activity" RELATED [EC:2.1.1.9] +synonym: "TMT" RELATED [EC:2.1.1.9] +xref: EC:2.1.1.9 +xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME" +xref: RHEA:18277 +xref: UM-BBD_enzymeID:e0146 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0018710 +name: acetone carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18385] +synonym: "acetone:carbon-dioxide ligase (AMP-forming)" RELATED [EC:6.4.1.6] +xref: EC:6.4.1.6 +xref: KEGG_REACTION:R05735 +xref: MetaCyc:6.4.1.6-RXN +xref: RHEA:18385 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018711 +name: benzoyl acetate-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243] +xref: MetaCyc:RXN-1305 +xref: UM-BBD_reactionID:r0243 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0018712 +name: 3-hydroxybutyryl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010] +xref: MetaCyc:R7-RXN +xref: UM-BBD_reactionID:r0010 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0018713 +name: 3-ketopimelyl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197] +xref: MetaCyc:RXN-8032 +xref: UM-BBD_reactionID:r0197 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0018715 +name: 9-phenanthrol UDP-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567] +xref: UM-BBD_reactionID:r0567 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0018716 +name: 1-phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525] +xref: UM-BBD_reactionID:r0525 +is_a: GO:0019112 ! phenanthrol glycosyltransferase activity + +[Term] +id: GO:0018717 +name: 9-phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511] +xref: UM-BBD_reactionID:r0511 +is_a: GO:0019112 ! phenanthrol glycosyltransferase activity + +[Term] +id: GO:0018718 +name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569] +xref: UM-BBD_reactionID:r0569 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0018719 +name: 6-aminohexanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449] +xref: MetaCyc:R562-RXN +xref: UM-BBD_reactionID:r0449 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0018720 +name: phenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_reactionID:r0155] +xref: MetaCyc:PHENOLPHOS-RXN +xref: UM-BBD_reactionID:r0155 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0018721 +name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559] +synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0559 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0018722 +name: 1-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565] +synonym: "1-phenanthrol sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0565 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018723 +name: 3-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561] +synonym: "3-phenanthrol sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0561 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018724 +name: 4-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562] +synonym: "4-phenanthrol sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0562 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018725 +name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558] +synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0558 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0018726 +name: 9-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564] +synonym: "9-phenanthrol sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0564 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018727 +name: 2-phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563] +synonym: "2-phenanthrol sulphotransferase activity" EXACT [] +xref: UM-BBD_reactionID:r0563 +is_a: GO:0019111 ! phenanthrol sulfotransferase activity + +[Term] +id: GO:0018729 +name: propionate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] +synonym: "acetyl-CoA:propanoate CoA-transferase activity" RELATED [EC:2.8.3.1] +synonym: "propionate coenzyme A-transferase activity" RELATED [EC:2.8.3.1] +synonym: "propionate-CoA:lactoyl-CoA transferase activity" RELATED [EC:2.8.3.1] +synonym: "propionyl CoA:acetate CoA transferase activity" RELATED [EC:2.8.3.1] +synonym: "propionyl-CoA transferase activity" RELATED [EC:2.8.3.1] +xref: EC:2.8.3.1 +xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN +xref: RHEA:23520 +xref: UM-BBD_reactionID:r0087 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0018730 +name: glutaconate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] +synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" RELATED [EC:2.8.3.12] +xref: EC:2.8.3.12 +xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN +xref: RHEA:23208 +xref: UM-BBD_reactionID:r0085 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0018731 +name: 1-oxa-2-oxocycloheptane lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167] +xref: UM-BBD_reactionID:r0167 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0018732 +name: sulfolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583] +synonym: "sulpholactone hydrolase activity" EXACT [] +xref: EC:3.1.1.92 +xref: UM-BBD_reactionID:r0583 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0018733 +name: 3,4-dihydrocoumarin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419] +xref: EC:3.1.1.35 +xref: UM-BBD_reactionID:r0419 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0018734 +name: butyrolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_reactionID:r0016] +xref: UM-BBD_reactionID:r0016 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0018736 +name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206] +xref: UM-BBD_reactionID:r0206 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018737 +name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193] +xref: UM-BBD_reactionID:r0193 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018738 +name: S-formylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14961] +subset: goslim_chembl +xref: EC:3.1.2.12 +xref: KEGG_REACTION:R00527 +xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN +xref: Reactome:R-HSA-5693724 "ESD dimer hydrolyses S-FGSH to GSH" +xref: RHEA:14961 +xref: UM-BBD_reactionID:r0241 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0018739 +name: 4-hydroxybenzoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11948] +synonym: "4-hydroxybenzoyl-CoA hydrolase activity" RELATED [EC:3.1.2.23] +synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] +xref: EC:3.1.2.23 +xref: KEGG_REACTION:R01301 +xref: MetaCyc:3.1.2.23-RXN +xref: RHEA:11948 +xref: UM-BBD_reactionID:r0141 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0018740 +name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12945] +synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] +synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" RELATED [EC:3.13.1.3] +synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] +synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] +synonym: "DszB" RELATED [EC:3.13.1.3] +synonym: "gene dszB-encoded hydrolase activity" RELATED [EC:3.13.1.3] +synonym: "HBPSi desulfinase activity" RELATED [EC:3.13.1.3] +synonym: "HPBS desulfinase activity" RELATED [EC:3.13.1.3] +xref: EC:3.13.1.3 +xref: KEGG_REACTION:R07311 +xref: MetaCyc:RXN-624 +xref: RHEA:12945 +xref: UM-BBD_enzymeID:e0216 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0018741 +name: alkyl sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602] +synonym: "alkyl sulphatase activity" EXACT [] +xref: EC:3.1.6.- +xref: UM-BBD_reactionID:r0602 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0018742 +name: epoxide hydrolase B activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0051 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018743 +name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560] +xref: EC:3.3.2.- +xref: UM-BBD_reactionID:r0560 +is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity + +[Term] +id: GO:0018744 +name: limonene-1,2-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] +synonym: "limonene oxide hydrolase activity" RELATED [EC:3.3.2.8] +xref: EC:3.3.2.8 +xref: MetaCyc:3.3.2.8-RXN +xref: RHEA:10700 +xref: UM-BBD_reactionID:r0734 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018745 +name: epoxide hydrolase A activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] +xref: EC:3.3.2.- +xref: UM-BBD_enzymeID:e0049 +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0018746 +name: phenanthrene-3,4-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535] +xref: UM-BBD_reactionID:r0535 +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0018747 +name: phenanthrene-1,2-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536] +xref: UM-BBD_reactionID:r0536 +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0018748 +name: iprodione amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706] +xref: UM-BBD_reactionID:r0706 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018749 +name: (3,5-dichlorophenylurea)acetate amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708] +xref: UM-BBD_reactionID:r0708 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018750 +name: biuret amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] +xref: EC:3.5.1.84 +xref: RHEA:17525 +xref: UM-BBD_reactionID:r0846 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0018751 +name: 3,5-dichlorophenylcarboximide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707] +xref: UM-BBD_reactionID:r0707 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018752 +name: epsilon-caprolactam lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448] +xref: MetaCyc:R561-RXN +xref: UM-BBD_reactionID:r0448 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018753 +name: cyanuric acid amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] +xref: EC:3.5.2.15 +xref: MetaCyc:R468-RXN +xref: RHEA:14641 +xref: UM-BBD_reactionID:r0116 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0018754 +name: ammelide aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] +xref: MetaCyc:RXN-8017 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018755 +name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018756 +name: ammeline aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] +xref: MetaCyc:RXN-8016 +xref: RHEA:26201 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018757 +name: deisopropylhydroxyatrazine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121] +xref: KEGG_REACTION:R05574 +xref: UM-BBD_reactionID:r0121 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018758 +name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122] +xref: UM-BBD_reactionID:r0122 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0018759 +name: methenyltetrahydromethanopterin cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19053] +synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" RELATED [EC:3.5.4.27] +synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" RELATED [EC:3.5.4.27] +synonym: "methenyl-H(4)MPT cyclohydrolase activity" RELATED [EC:3.5.4.27] +synonym: "methenyl-H4MPT cyclohydrolase activity" RELATED [EC:3.5.4.27] +synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" RELATED [EC:3.5.4.27] +xref: EC:3.5.4.27 +xref: KEGG_REACTION:R03464 +xref: MetaCyc:3.5.4.27-RXN +xref: RHEA:19053 +xref: UM-BBD_reactionID:r0347 +is_a: GO:0019238 ! cyclohydrolase activity + +[Term] +id: GO:0018760 +name: thiocyanate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21464] +synonym: "thiocyanate aminohydrolase activity" RELATED [EC:3.5.5.8] +xref: EC:3.5.5.8 +xref: KEGG_REACTION:R05780 +xref: MetaCyc:RXN-1761 +xref: RHEA:21464 +xref: UM-BBD_reactionID:r0598 +is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles + +[Term] +id: GO:0018761 +name: bromoxynil nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22100] +synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] +synonym: "bromoxynil-specific nitrilase activity" EXACT [] +xref: EC:3.5.5.6 +xref: KEGG_REACTION:R04349 +xref: MetaCyc:3.5.5.6-RXN +xref: RHEA:22100 +xref: UM-BBD_enzymeID:e0357 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0018762 +name: aliphatic nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] +synonym: "aliphatic nitrile aminohydrolase activity" RELATED [EC:3.5.5.7] +xref: EC:3.5.5.7 +xref: MetaCyc:3.5.5.7-RXN +xref: RHEA:46188 +xref: UM-BBD_reactionID:r0622 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0018763 +name: hydroxydechloroatrazine ethylaminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.4.43] +synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" RELATED [EC:3.5.4.43] +synonym: "AtzB" RELATED [] +synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] +synonym: "hydroxyatrazine hydrolase activity" RELATED [EC:3.5.4.43] +xref: EC:3.5.4.43 +xref: MetaCyc:R122-RXN +xref: RHEA:23092 +xref: UM-BBD_enzymeID:e0085 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0018764 +name: N-isopropylammelide isopropylaminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.4.42] +synonym: "AtzC" RELATED [] +xref: EC:3.5.4.42 +xref: MetaCyc:R123-RXN +xref: RHEA:23608 +xref: UM-BBD_enzymeID:e0086 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0018765 +name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263] +xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN +xref: RHEA:59220 +xref: UM-BBD_reactionID:r0263 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018766 +name: dihydrophloroglucinol hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008] +xref: KEGG_REACTION:R07831 +xref: MetaCyc:R6-RXN +xref: UM-BBD_reactionID:r0008 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018767 +name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399] +xref: UM-BBD_reactionID:r0399 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018768 +name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458] +xref: EC:3.7.1.13 +xref: UM-BBD_reactionID:r0458 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018769 +name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311] +xref: UM-BBD_reactionID:r0311 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018770 +name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444] +xref: UM-BBD_reactionID:r0444 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018771 +name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity +namespace: molecular_function +alt_id: GO:0008680 +def: "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:24789] +synonym: "(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14] +synonym: "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r0438] +xref: EC:3.7.1.14 +xref: MetaCyc:MHPCHYDROL-RXN +xref: RHEA:24789 +xref: UM-BBD_reactionID:r0438 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018772 +name: trioxoheptanoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094] +xref: MetaCyc:R306-RXN +xref: UM-BBD_reactionID:r0094 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018773 +name: acetylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16097] +synonym: "2,4-dioxopentanoate acetylhydrolase activity" RELATED [EC:3.7.1.6] +xref: EC:3.7.1.6 +xref: KEGG_REACTION:R00324 +xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN +xref: RHEA:16097 +xref: UM-BBD_reactionID:r0095 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018774 +name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] +synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" RELATED [EC:3.7.1.8] +synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] +synonym: "HOHPDA hydrolase activity" RELATED [EC:3.7.1.8] +xref: EC:3.7.1.8 +xref: MetaCyc:3.7.1.8-RXN +xref: RHEA:17161 +xref: UM-BBD_enzymeID:e0033 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018775 +name: 2-hydroxymuconate-semialdehyde hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] +synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" RELATED [EC:3.7.1.9] +synonym: "2-hydroxymuconic semialdehyde hydrolase activity" RELATED [EC:3.7.1.9] +synonym: "HMSH" RELATED [EC:3.7.1.9] +synonym: "HOD hydrolase activity" RELATED [EC:3.7.1.9] +xref: EC:3.7.1.9 +xref: MetaCyc:3.7.1.9-RXN +xref: RHEA:14549 +xref: UM-BBD_enzymeID:e0139 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0018776 +name: trans-chloroacrylic acid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689] +xref: UM-BBD_reactionID:r0689 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018777 +name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018778 +name: DL-2 haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382] +xref: EC:3.8.1.10 +xref: MetaCyc:RXN-9150 +xref: UM-BBD_reactionID:r0382 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018779 +name: obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0018780 +name: dichloroacetate halidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_reactionID:r0383] +xref: UM-BBD_reactionID:r0383 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018781 +name: S-triazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] +xref: UM-BBD_enzymeID:e0091 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018782 +name: cis-chloroacrylic acid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688] +xref: UM-BBD_reactionID:r0688 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018783 +name: deisopropyldeethylatrazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018784 +name: (S)-2-haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] +synonym: "(S)-2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.2] +synonym: "2-haloacid dehalogenase activity" EXACT [] +synonym: "2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.2] +synonym: "2-haloalkanoic acid dehalogenase activity" RELATED [EC:3.8.1.2] +synonym: "2-haloalkanoid acid halidohydrolase activity" RELATED [EC:3.8.1.2] +synonym: "2-halocarboxylic acid dehalogenase II activity" RELATED [EC:3.8.1.2] +synonym: "DL-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.2] +synonym: "halocarboxylic acid halidohydrolase activity" RELATED [EC:3.8.1.2] +synonym: "L-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.2] +synonym: "L-DEX activity" RELATED [EC:3.8.1.2] +xref: EC:3.8.1.2 +xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN +xref: RHEA:11192 +xref: UM-BBD_reactionID:r0090 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018785 +name: haloacetate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] +synonym: "haloacetate halidohydrolase activity" RELATED [EC:3.8.1.3] +synonym: "monohaloacetate dehalogenase activity" RELATED [EC:3.8.1.3] +xref: EC:3.8.1.3 +xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN +xref: RHEA:11044 +xref: UM-BBD_enzymeID:e0006 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018786 +name: haloalkane dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [RHEA:19081] +synonym: "1-chlorohexane halidohydrolase activity" RELATED [EC:3.8.1.5] +synonym: "1-haloalkane dehalogenase activity" RELATED [EC:3.8.1.5] +synonym: "1-haloalkane halidohydrolase activity" RELATED [EC:3.8.1.5] +xref: EC:3.8.1.5 +xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN +xref: RHEA:19081 +xref: UM-BBD_enzymeID:e0003 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018787 +name: 4-chlorobenzoyl-CoA dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] +synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" RELATED [EC:3.8.1.7] +xref: EC:3.8.1.7 +xref: MetaCyc:3.8.1.7-RXN +xref: RHEA:14853 +xref: UM-BBD_enzymeID:e0113 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018788 +name: atrazine chlorohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11312] +synonym: "AtzA" RELATED [EC:3.8.1.8] +xref: EC:3.8.1.8 +xref: KEGG_REACTION:R05558 +xref: MetaCyc:3.8.1.8-RXN +xref: RHEA:11312 +xref: UM-BBD_reactionID:r0113 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0018789 +name: cyclamate sulfohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18481] +synonym: "cyclamate sulfamatase activity" EXACT [] +synonym: "cyclamate sulfamidase activity" RELATED [EC:3.10.1.2] +synonym: "cyclamate sulphohydrolase activity" EXACT [] +synonym: "cyclohexylsulfamate sulfamidase activity" RELATED [EC:3.10.1.2] +synonym: "cyclohexylsulfamate sulfohydrolase activity" RELATED [EC:3.10.1.2] +xref: EC:3.10.1.2 +xref: KEGG_REACTION:R02564 +xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN +xref: RHEA:18481 +xref: UM-BBD_reactionID:r0755 +is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds + +[Term] +id: GO:0018791 +name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398] +xref: UM-BBD_reactionID:r0398 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018792 +name: bis(4-chlorophenyl)acetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520] +synonym: "DDA decarboxylase activity" EXACT [] +xref: UM-BBD_reactionID:r0520 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018793 +name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546] +xref: UM-BBD_reactionID:r0546 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018794 +name: 2-hydroxyisobutyrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617] +xref: UM-BBD_reactionID:r0617 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018795 +name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621] +xref: UM-BBD_reactionID:r0621 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018796 +name: 4,5-dihydroxyphthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] +synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" RELATED [EC:4.1.1.55] +synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" RELATED [EC:4.1.1.55] +xref: EC:4.1.1.55 +xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN +xref: RHEA:24184 +xref: UM-BBD_enzymeID:e0106 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018798 +name: gallate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol." [EC:4.1.1.59, RHEA:12749] +synonym: "gallate carboxy-lyase (pyrogallol-forming)" RELATED [EC:4.1.1.59] +synonym: "gallate carboxy-lyase activity" RELATED [EC:4.1.1.59] +synonym: "gallic acid decarboxylase activity" EXACT [] +xref: EC:4.1.1.59 +xref: KEGG_REACTION:R03247 +xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN +xref: RHEA:12749 +xref: UM-BBD_reactionID:r0005 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018799 +name: 4-hydroxybenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol." [EC:4.1.1.61, RHEA:10876] +synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" RELATED [EC:4.1.1.61] +synonym: "4-hydroxybenzoate carboxy-lyase activity" RELATED [EC:4.1.1.61] +synonym: "p-hydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.61] +xref: EC:4.1.1.61 +xref: KEGG_REACTION:R01238 +xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN +xref: RHEA:10876 +xref: UM-BBD_reactionID:r0159 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018800 +name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68] +synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" RELATED [EC:4.1.1.68] +synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] +synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" RELATED [EC:4.1.1.68] +synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.68] +synonym: "HpaG-2" RELATED [] +synonym: "HpaG2" RELATED [] +synonym: "OPET decarboxylase activity" EXACT [] +xref: EC:4.1.1.68 +xref: MetaCyc:4.1.1.68-RXN +xref: RHEA:14397 +xref: UM-BBD_reactionID:r0367 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018801 +name: glutaconyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [PMID:11248185, RHEA:23972] +synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [] +synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.5] +synonym: "glutaconyl coenzyme A decarboxylase activity" RELATED [EC:7.2.4.5] +synonym: "pent-2-enoyl-CoA carboxy-lyase activity" RELATED [EC:7.2.4.5] +xref: EC:7.2.4.5 +xref: KEGG_REACTION:R03028 +xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN +xref: RHEA:23972 +xref: UM-BBD_reactionID:r0199 +is_a: GO:0015451 ! decarboxylation-driven active transmembrane transporter activity +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018802 +name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [PMID:8529896] +xref: UM-BBD_reactionID:r0370 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018803 +name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] +synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] +synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.34] +synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] +synonym: "2'-carboxybenzalpyruvate aldolase activity" RELATED [EC:4.1.2.34] +synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] +xref: EC:4.1.2.34 +xref: MetaCyc:4.1.2.34-RXN +xref: RHEA:16453 +xref: UM-BBD_reactionID:r0487 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0018805 +name: benzylsuccinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10416] +synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" RELATED [EC:4.1.99.11] +synonym: "benzylsuccinate fumarate-lyase activity" RELATED [EC:4.1.99.11] +xref: EC:4.1.99.11 +xref: KEGG_REACTION:R05598 +xref: MetaCyc:RXN-863 +xref: RHEA:10416 +xref: UM-BBD_enzymeID:e0259 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0018807 +name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204] +xref: EC:3.7.1.21 +xref: RHEA:39651 +xref: UM-BBD_reactionID:r0204 +is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds + +[Term] +id: GO:0018808 +name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484] +xref: UM-BBD_reactionID:r0484 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018809 +name: E-phenylitaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331] +xref: UM-BBD_reactionID:r0331 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018810 +name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164] +xref: UM-BBD_reactionID:r0164 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018811 +name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191] +xref: MetaCyc:R266-RXN +xref: UM-BBD_reactionID:r0191 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018812 +name: 3-hydroxyacyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] +xref: Reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA" +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018813 +name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] +xref: EC:4.1.2.45 +xref: RHEA:27389 +xref: UM-BBD_enzymeID:e0257 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018814 +name: phenylacetaldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20069] +synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" RELATED [EC:4.99.1.7] +synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.7] +synonym: "arylacetaldoxime dehydratase activity" RELATED [EC:4.99.1.7] +synonym: "OxdB" RELATED [EC:4.99.1.7] +synonym: "PAOx dehydratase activity" RELATED [EC:4.99.1.7] +xref: EC:4.99.1.7 +xref: KEGG_REACTION:R07638 +xref: MetaCyc:4.99.1.7-RXN +xref: RHEA:20069 +xref: UM-BBD_reactionID:r0697 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0018815 +name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051] +xref: MetaCyc:RXN-645 +xref: UM-BBD_reactionID:r0051 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018816 +name: 2-hydroxyisobutyrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_reactionID:r0618] +xref: UM-BBD_reactionID:r0618 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018817 +name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369] +synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] +synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] +synonym: "HpaH" RELATED [] +xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN +xref: RHEA:42072 +xref: UM-BBD_reactionID:r0369 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018818 +name: acetylene hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O." [EC:4.2.1.112, RHEA:17885] +synonym: "acetaldehyde hydro-lyase activity" RELATED [EC:4.2.1.112] +synonym: "AH" RELATED [EC:4.2.1.112] +synonym: "AHy" RELATED [EC:4.2.1.112] +xref: EC:4.2.1.112 +xref: KEGG_REACTION:R05380 +xref: MetaCyc:R141-RXN +xref: RHEA:17885 +xref: UM-BBD_reactionID:r0591 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018819 +name: lactoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] +synonym: "acrylyl coenzyme A hydratase activity" RELATED [EC:4.2.1.54] +synonym: "lactoyl coenzyme A dehydratase activity" RELATED [EC:4.2.1.54] +synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" RELATED [EC:4.2.1.54] +synonym: "lactoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.54] +synonym: "lactyl CoA dehydratase activity" RELATED [EC:4.2.1.54] +synonym: "lactyl-coenzyme A dehydrase activity" RELATED [EC:4.2.1.54] +xref: EC:4.2.1.54 +xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN +xref: MetaCyc:RXN-781 +xref: RHEA:21056 +xref: UM-BBD_reactionID:r0086 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018820 +name: cyanamide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: urea = cyanamide + H(2)O." [EC:4.2.1.69, RHEA:23056] +synonym: "urea hydro-lyase (cyanamide-forming)" RELATED [EC:4.2.1.69] +synonym: "urea hydro-lyase activity" RELATED [EC:4.2.1.69] +xref: EC:4.2.1.69 +xref: KEGG_REACTION:R00778 +xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN +xref: RHEA:23056 +xref: UM-BBD_reactionID:r0668 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018822 +name: nitrile hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [RHEA:12673] +synonym: "3-cyanopyridine hydratase activity" NARROW [] +synonym: "acrylonitrile hydratase activity" RELATED [] +synonym: "aliphatic nitrile hydratase activity" RELATED [] +synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" RELATED [] +synonym: "H-NHase activity" RELATED [] +synonym: "L-NHase activity" RELATED [] +synonym: "NHase activity" RELATED [] +synonym: "nitrile hydro-lyase activity" RELATED [EC:4.2.1.84] +xref: EC:4.2.1.84 +xref: MetaCyc:NITRILE-HYDRATASE-RXN +xref: RHEA:12673 +xref: UM-BBD_enzymeID:e0067 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018823 +name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21856] +synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] +synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] +synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" RELATED [EC:4.2.1.100] +synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" RELATED [EC:4.2.1.100] +synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.100] +synonym: "dienoyl-CoA hydratase activity" RELATED [EC:4.2.1.100] +xref: EC:4.2.1.100 +xref: KEGG_REACTION:R05597 +xref: MetaCyc:4.2.1.100-RXN +xref: RHEA:21856 +xref: UM-BBD_reactionID:r0203 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0018824 +name: (hydroxyamino)benzene mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304] +synonym: "(hydroxyamino)benzene hydroxymutase activity" RELATED [EC:5.4.4.1] +synonym: "HAB mutase activity" RELATED [EC:5.4.4.1] +synonym: "hydroxylaminobenzene hydroxymutase activity" RELATED [EC:5.4.4.1] +synonym: "hydroxylaminobenzene mutase activity" RELATED [EC:5.4.4.1] +xref: MetaCyc:5.4.4.1-RXN +xref: RHEA:19245 +xref: UM-BBD_reactionID:r0304 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0018825 +name: triethanolamine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] +xref: UM-BBD_enzymeID:e0421 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0018826 +name: methionine gamma-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11, RHEA:23800] +synonym: "L-methioninase activity" RELATED [EC:4.4.1.11] +synonym: "L-methionine gamma-lyase activity" RELATED [EC:4.4.1.11] +synonym: "L-methionine methanethiol-lyase (deaminating)" RELATED [EC:4.4.1.11] +synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.11] +synonym: "methioninase activity" RELATED [EC:4.4.1.11] +synonym: "methionine dethiomethylase activity" RELATED [EC:4.4.1.11] +synonym: "methionine lyase activity" RELATED [EC:4.4.1.11] +xref: EC:4.4.1.11 +xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN +xref: RHEA:23800 +xref: UM-BBD_reactionID:r0432 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0018827 +name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515] +synonym: "DDMS dehydrochlorinase activity" EXACT [] +xref: EC:4.5.1.- +xref: UM-BBD_reactionID:r0515 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018828 +name: halohydrin hydrogen-halide-lyase A activity +namespace: molecular_function +def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] +xref: UM-BBD_enzymeID:e0048 +is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity + +[Term] +id: GO:0018829 +name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513] +synonym: "DDD dehydrochlorinase activity" EXACT [] +xref: EC:4.5.1.- +xref: UM-BBD_reactionID:r0513 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018830 +name: gamma-hexachlorocyclohexane dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] +xref: EC:4.5.1.- +xref: UM-BBD_enzymeID:e0359 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018831 +name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666] +xref: EC:4.5.1.- +xref: UM-BBD_reactionID:r0666 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018832 +name: halohydrin hydrogen-halide-lyase B activity +namespace: molecular_function +def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] +xref: UM-BBD_enzymeID:e0050 +is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity + +[Term] +id: GO:0018833 +name: DDT-dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19217] +synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] +synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" RELATED [EC:4.5.1.1] +synonym: "DDT dehydrochlorinase activity" EXACT [] +synonym: "DDT-as" RELATED [EC:4.5.1.1] +synonym: "DDT-ase activity" RELATED [EC:4.5.1.1] +synonym: "DDTase activity" RELATED [EC:4.5.1.1] +xref: EC:4.5.1.1 +xref: KEGG_REACTION:R04522 +xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN +xref: RHEA:19217 +xref: UM-BBD_reactionID:r0439 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018834 +name: dichloromethane dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15397] +synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" RELATED [EC:4.5.1.3] +synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" RELATED [EC:4.5.1.3] +xref: EC:4.5.1.3 +xref: KEGG_REACTION:R00603 +xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN +xref: RHEA:15397 +xref: UM-BBD_reactionID:r0188 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0018835 +name: carbon phosphorus lyase activity +namespace: molecular_function +alt_id: GO:0009456 +def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975] +xref: EC:4.7.1.- +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0018836 +name: alkylmercury lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alkylmercury + H+ = an alkane + Hg2+." [RHEA:18777] +synonym: "alkylmercury mercuric-lyase (alkane-forming)" RELATED [EC:4.99.1.2] +synonym: "alkylmercury mercuric-lyase activity" RELATED [EC:4.99.1.2] +synonym: "organomercurial lyase activity" RELATED [EC:4.99.1.2] +synonym: "organomercury lyase activity" RELATED [EC:4.99.1.2] +xref: EC:4.99.1.2 +xref: MetaCyc:ALKYLMERCURY-LYASE-RXN +xref: RHEA:18777 +xref: UM-BBD_enzymeID:e0055 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0018837 +name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502] +xref: UM-BBD_reactionID:r0502 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0018838 +name: mandelate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] +xref: EC:5.1.2.2 +xref: MetaCyc:MANDELATE-RACEMASE-RXN +xref: RHEA:13945 +xref: UM-BBD_reactionID:r0091 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0018839 +name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163] +xref: EC:5.2.1.- +xref: UM-BBD_reactionID:r0163 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0018844 +name: 2-hydroxytetrahydrofuran isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019] +xref: EC:5.3.99.- +xref: UM-BBD_reactionID:r0019 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018845 +name: 2-hydroxychromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27401] +xref: EC:5.99.1.4 +xref: KEGG_REACTION:R05137 +xref: MetaCyc:RXNN-386 +xref: RHEA:27401 +xref: UM-BBD_reactionID:r0337 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018846 +name: styrene-oxide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21604] +synonym: "SOI activity" RELATED [EC:5.3.99.7] +synonym: "styrene oxide isomerase activity" EXACT [] +synonym: "styrene-oxide isomerase (epoxide-cleaving)" RELATED [EC:5.3.99.7] +xref: EC:5.3.99.7 +xref: KEGG_REACTION:R02615 +xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN +xref: RHEA:21604 +xref: UM-BBD_reactionID:r0034 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0018847 +name: alpha-pinene lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712] +xref: EC:5.5.1.- +xref: UM-BBD_reactionID:r0712 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018848 +name: pinocarveol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715] +xref: EC:5.5.1.- +xref: UM-BBD_reactionID:r0715 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018849 +name: muconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [RHEA:30031] +synonym: "cis,cis-muconate cycloisomerase activity" RELATED [EC:5.5.1.1] +synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] +synonym: "muconate cycloisomerase I activity" RELATED [EC:5.5.1.1] +synonym: "muconate lactonizing enzyme activity" RELATED [EC:5.5.1.1] +synonym: "muconate lactonizing enzyme I activity" RELATED [EC:5.5.1.1] +xref: EC:5.5.1.1 +xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN +xref: RHEA:30031 +xref: UM-BBD_enzymeID:e0133 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018850 +name: chloromuconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] +synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.7] +synonym: "muconate cycloisomerase II activity" RELATED [EC:5.5.1.7] +xref: EC:5.5.1.7 +xref: RHEA:11032 +xref: UM-BBD_enzymeID:e0065 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018851 +name: alpha-pinene-oxide decyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16693] +synonym: "alpha-pinene oxide lyase activity" EXACT [] +synonym: "alpha-pinene-oxide lyase (decyclizing)" RELATED [EC:5.5.1.10] +xref: EC:5.5.1.10 +xref: KEGG_REACTION:R04040 +xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN +xref: RHEA:16693 +xref: UM-BBD_reactionID:r0743 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018852 +name: dichloromuconate cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] +synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.11] +xref: EC:5.5.1.11 +xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN +xref: RHEA:17437 +xref: UM-BBD_reactionID:r0277 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0018853 +name: obsolete perillyl-CoA synthetase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731] +comment: This term was made obsolete because it represents two reactions. +synonym: "perillyl-CoA synthetase activity" EXACT [] +xref: EC:6.2.1.- +xref: UM-BBD_reactionID:r0731 +is_obsolete: true +consider: GO:0052685 +consider: GO:0052686 + +[Term] +id: GO:0018854 +name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737] +xref: UM-BBD_reactionID:r0737 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018855 +name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429] +xref: EC:6.2.1.38 +xref: RHEA:33419 +xref: UM-BBD_reactionID:r0429 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018856 +name: benzoyl acetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242] +xref: KEGG_REACTION:R05452 +xref: SABIO-RK:5058 +xref: UM-BBD_reactionID:r0242 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018857 +name: 2,4-dichlorobenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137] +xref: UM-BBD_reactionID:r0137 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018858 +name: benzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate." [EC:6.2.1.25, RHEA:10132] +synonym: "benzoate-coenzyme A ligase activity" RELATED [EC:6.2.1.25] +synonym: "benzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.25] +synonym: "benzoyl CoA synthetase (AMP forming)" RELATED [EC:6.2.1.25] +synonym: "benzoyl-coenzyme A synthetase activity" RELATED [EC:6.2.1.25] +xref: EC:6.2.1.25 +xref: KEGG_REACTION:R01422 +xref: MetaCyc:BENZOATE--COA-LIGASE-RXN +xref: RHEA:10132 +xref: UM-BBD_reactionID:r0189 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018859 +name: 4-hydroxybenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] +synonym: "4-hydroxybenzoate-CoA synthetase activity" RELATED [EC:6.2.1.27] +synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" RELATED [EC:6.2.1.27] +synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.27] +synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.27] +synonym: "4-hydroxybenzoyl-CoA ligase activity" RELATED [EC:6.2.1.27] +xref: EC:6.2.1.27 +xref: KEGG_REACTION:R01300 +xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN +xref: RHEA:23116 +xref: UM-BBD_reactionID:r0156 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018860 +name: anthranilate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] +synonym: "2-aminobenzoate coenzyme A ligase activity" RELATED [EC:6.2.1.32] +synonym: "2-aminobenzoate-CoA ligase activity" RELATED [EC:6.2.1.32] +synonym: "2-aminobenzoate-coenzyme A ligase activity" RELATED [EC:6.2.1.32] +synonym: "anthranilate--CoA ligase activity" EXACT [] +synonym: "anthranilate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.32] +synonym: "anthraniloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.32] +xref: EC:6.2.1.32 +xref: KEGG_REACTION:R00982 +xref: MetaCyc:AMINOBENZCOALIG-RXN +xref: RHEA:10828 +xref: UM-BBD_reactionID:r0341 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018861 +name: 4-chlorobenzoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] +synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] +xref: EC:6.2.1.33 +xref: KEGG_REACTION:R03932 +xref: MetaCyc:6.2.1.33-RXN +xref: RHEA:23220 +xref: UM-BBD_reactionID:r0139 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0018862 +name: phenylphosphate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157] +xref: EC:6.4.1.- +xref: MetaCyc:PHENYLPCARB-RXN +xref: UM-BBD_reactionID:r0157 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0018863 +name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496] +xref: EC:3.3.2.- +xref: UM-BBD_reactionID:r0496 +is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity + +[Term] +id: GO:0018864 +name: acetylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544] +synonym: "acetylene metabolism" EXACT [] +synonym: "ethyne metabolic process" EXACT [] +synonym: "ethyne metabolism" EXACT [] +xref: UM-BBD_pathwayID:atl +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043452 ! cellular alkyne metabolic process +is_a: GO:0120244 ! terminal acetylenic compound metabolic process + +[Term] +id: GO:0018865 +name: acrylonitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm] +synonym: "acrylonitrile metabolism" EXACT [] +xref: UM-BBD_pathwayID:acr +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0018866 +name: adamantanone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] +synonym: "adamantanone metabolism" EXACT [] +xref: UM-BBD_pathwayID:ada +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018867 +name: alpha-pinene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn] +synonym: "alpha-pinene metabolism" EXACT [] +xref: UM-BBD_pathwayID:apn +is_a: GO:0033073 ! pinene metabolic process + +[Term] +id: GO:0018868 +name: 2-aminobenzenesulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] +synonym: "2-aminobenzenesulfonate metabolism" EXACT [] +synonym: "2-aminobenzenesulphonate metabolic process" EXACT [] +synonym: "2-aminobenzenesulphonate metabolism" EXACT [] +xref: UM-BBD_pathwayID:abs +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018870 +name: anaerobic 2-aminobenzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai] +synonym: "anaerobic 2-aminobenzoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:abz +is_a: GO:0018875 ! anaerobic benzoate metabolic process +is_a: GO:0043420 ! anthranilate metabolic process + +[Term] +id: GO:0018871 +name: 1-aminocyclopropane-1-carboxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp] +synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT [] +synonym: "ACP metabolic process" EXACT [] +synonym: "ACP metabolism" EXACT [] +xref: UM-BBD_pathwayID:acp +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0018872 +name: arsonoacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara] +synonym: "arsonoacetate metabolism" EXACT [] +xref: UM-BBD_pathwayID:ara +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018873 +name: atrazine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr] +synonym: "atrazine metabolism" EXACT [] +xref: UM-BBD_pathwayID:atr +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0018965 ! s-triazine compound metabolic process + +[Term] +id: GO:0018874 +name: benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544] +synonym: "benzoate metabolism" EXACT [] +xref: MetaCyc:P321-PWY +xref: UM-BBD_pathwayID:benz2 +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018875 +name: anaerobic benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic benzoate metabolism" EXACT [] +xref: MetaCyc:CENTBENZCOA-PWY +xref: UM-BBD_pathwayID:benz +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0018876 +name: benzonitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn] +synonym: "benzonitrile metabolism" EXACT [] +xref: UM-BBD_pathwayID:bzn +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0018877 +name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch] +synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +xref: UM-BBD_pathwayID:hch +is_a: GO:0019497 ! hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018878 +name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai] +synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018879 +name: biphenyl metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl] +synonym: "biphenyl metabolism" EXACT [] +synonym: "xenene metabolic process" EXACT [] +synonym: "xenene metabolism" EXACT [] +xref: UM-BBD_pathwayID:bph +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018880 +name: 4-chlorobiphenyl metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl] +synonym: "4-chlorobiphenyl metabolism" EXACT [] +xref: UM-BBD_pathwayID:cbp +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018881 +name: bromoxynil metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] +synonym: "bromoxynil metabolism" EXACT [] +xref: UM-BBD_pathwayID:box +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0018882 +name: (+)-camphor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam] +synonym: "(+)-camphor metabolism" EXACT [] +synonym: "camphor metabolic process" EXACT [] +synonym: "camphor metabolism" EXACT [] +xref: UM-BBD_pathwayID:cam +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0018883 +name: caprolactam metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [GOC:curators] +synonym: "caprolactam metabolism" EXACT [] +xref: UM-BBD_pathwayID:cap +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0072338 ! cellular lactam metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018884 +name: carbazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl] +synonym: "CAR metabolic process" EXACT [] +synonym: "CAR metabolism" EXACT [] +synonym: "carbazole metabolism" EXACT [] +xref: UM-BBD_pathwayID:car +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018885 +name: carbon tetrachloride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc] +synonym: "carbon tetrachloride metabolism" EXACT [] +xref: UM-BBD_pathwayID:ctc +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018886 +name: anaerobic carbon tetrachloride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic carbon tetrachloride metabolism" EXACT [] +xref: UM-BBD_pathwayID:ctc +is_a: GO:0018885 ! carbon tetrachloride metabolic process + +[Term] +id: GO:0018887 +name: 4-carboxy-4'-sulfoazobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860] +synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT [] +synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT [] +synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:csab +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018888 +name: 3-chloroacrylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai] +synonym: "3-chloroacrylic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:caa +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0018889 +name: 2-chloro-N-isopropylacetanilide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc] +synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] +synonym: "propachlor metabolic process" EXACT [] +synonym: "propachlor metabolism" EXACT [] +xref: UM-BBD_pathwayID:ppc +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018890 +name: cyanamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [GOC:curators] +synonym: "cyanamide metabolism" EXACT [] +xref: UM-BBD_pathwayID:cnm +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0018891 +name: cyclohexanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544] +synonym: "cyclohexanol metabolism" EXACT [] +xref: UM-BBD_pathwayID:chx +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0018892 +name: cyclohexylsulfamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs] +synonym: "cyclohexylsulfamate metabolism" EXACT [] +synonym: "cyclohexylsulphamate metabolic process" EXACT [] +synonym: "cyclohexylsulphamate metabolism" EXACT [] +xref: UM-BBD_pathwayID:chs +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0018893 +name: dibenzofuran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf] +synonym: "dibenzofuran metabolism" EXACT [] +xref: UM-BBD_pathwayID:dbf +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018894 +name: dibenzo-p-dioxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd] +synonym: "dibenzo-p-dioxin metabolism" EXACT [] +synonym: "oxanthrene metabolic process" EXACT [] +synonym: "oxanthrene metabolism" EXACT [] +synonym: "phenodioxin metabolic process" EXACT [] +synonym: "phenodioxin metabolism" EXACT [] +xref: UM-BBD_pathwayID:dpd +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018895 +name: dibenzothiophene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483] +synonym: "dibenzothiophene metabolism" EXACT [] +synonym: "diphenylene sulfide metabolic process" EXACT [] +synonym: "diphenylene sulfide metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018896 +name: dibenzothiophene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] +synonym: "dibenzothiophene breakdown" EXACT [] +synonym: "dibenzothiophene catabolism" EXACT [] +synonym: "dibenzothiophene degradation" EXACT [] +xref: UM-BBD_pathwayID:dbt2 +is_a: GO:0018895 ! dibenzothiophene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0018897 +name: dibenzothiophene desulfurization +namespace: biological_process +def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] +synonym: "dibenzothiophene desulphurization" EXACT [] +xref: MetaCyc:PWY-681 +xref: UM-BBD_pathwayID:dbt +is_a: GO:0018895 ! dibenzothiophene metabolic process + +[Term] +id: GO:0018898 +name: 2,4-dichlorobenzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb] +synonym: "2,4-dichlorobenzoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcb +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018899 +name: 1,2-dichloroethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl] +synonym: "1,2-dichloroethane metabolism" EXACT [] +xref: UM-BBD_pathwayID:dce +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018900 +name: dichloromethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm] +synonym: "dichloromethane metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcm +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018901 +name: 2,4-dichlorophenoxyacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] +synonym: "2,4-D metabolic process" EXACT [] +synonym: "2,4-D metabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:2\,4-d +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018902 +name: 1,3-dichloro-2-propanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp] +synonym: "1,3-dichloro-2-propanol metabolism" EXACT [] +synonym: "DCP metabolic process" EXACT [] +synonym: "DCP metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcp +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0044107 ! cellular alcohol metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0018903 +name: 1,3-dichloropropene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr] +synonym: "1,3-dichloropropene metabolism" EXACT [] +synonym: "1,3-dichloropropylene metabolic process" EXACT [] +synonym: "1,3-dichloropropylene metabolism" EXACT [] +synonym: "gamma-chloroallylchloride metabolic process" EXACT [] +synonym: "gamma-chloroallylchloride metabolism" EXACT [] +xref: UM-BBD_pathwayID:cpr +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018904 +name: ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732] +subset: goslim_pir +synonym: "ether metabolism" EXACT [] +synonym: "organic ether metabolic process" EXACT [] +synonym: "organic ether metabolism" EXACT [] +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018905 +name: dimethyl ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme] +synonym: "dimethyl ether metabolism" EXACT [] +synonym: "methyl ether metabolic process" EXACT [] +synonym: "methyl ether metabolism" EXACT [] +xref: UM-BBD_pathwayID:dme +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0018904 ! ether metabolic process + +[Term] +id: GO:0018906 +name: methyl tert-butyl ether metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb] +synonym: "methyl tert-butyl ether metabolism" EXACT [] +xref: UM-BBD_pathwayID:mtb +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0018904 ! ether metabolic process + +[Term] +id: GO:0018907 +name: dimethyl sulfoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [GOC:curators] +synonym: "dimethyl sulfoxide metabolism" EXACT [] +synonym: "dimethyl sulphoxide metabolic process" EXACT [] +synonym: "dimethyl sulphoxide metabolism" EXACT [] +synonym: "DMSO metabolic process" EXACT [] +synonym: "DMSO metabolism" EXACT [] +xref: UM-BBD_pathwayID:sulf +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018908 +name: organosulfide cycle +namespace: biological_process +def: "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf] +synonym: "organosulphide cycle" EXACT [] +xref: UM-BBD_pathwayID:sulf +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0018909 +name: dodecyl sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds] +synonym: "dodecyl sulfate metabolism" EXACT [] +synonym: "dodecyl sulphate metabolic process" EXACT [] +synonym: "dodecyl sulphate metabolism" EXACT [] +xref: UM-BBD_pathwayID:dds +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0018910 +name: benzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [GOC:ai] +synonym: "benzene metabolism" EXACT [] +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0018911 +name: 1,2,4-trichlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm] +synonym: "1,2,4-trichlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbz +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018912 +name: 1,4-dichlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] +synonym: "1,4-dichlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:dcz +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018913 +name: anaerobic ethylbenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic ethylbenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:ethb +is_a: GO:0018915 ! ethylbenzene metabolic process + +[Term] +id: GO:0018914 +name: chlorobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/] +synonym: "chlorobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:cb +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018915 +name: ethylbenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm] +synonym: "ethylbenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:ethb2 +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0018916 +name: nitrobenzene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [GOC:curators] +synonym: "nitrobenzene metabolism" EXACT [] +xref: UM-BBD_pathwayID:nb +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018919 +name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch] +synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] +xref: MetaCyc:GAMMAHEXCHLORDEG-PWY +xref: UM-BBD_pathwayID:ghch +is_a: GO:0019497 ! hexachlorocyclohexane metabolic process + +[Term] +id: GO:0018920 +name: glyphosate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly] +synonym: "glyphosate metabolism" EXACT [] +synonym: "Roundup metabolic process" EXACT [] +synonym: "Roundup metabolism" EXACT [] +xref: UM-BBD_pathwayID:gly +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0018921 +name: 3-hydroxybenzyl alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr] +synonym: "3-hydroxybenzyl alcohol metabolism" EXACT [] +xref: UM-BBD_pathwayID:mcr +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0018922 +name: iprodione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd] +synonym: "iprodione metabolism" EXACT [] +xref: UM-BBD_pathwayID:ipd +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0052803 ! imidazole-containing compound metabolic process + +[Term] +id: GO:0018923 +name: limonene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim] +synonym: "limonene metabolism" EXACT [] +xref: UM-BBD_pathwayID:lim +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:1900673 ! olefin metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018924 +name: mandelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl] +synonym: "mandelate metabolism" EXACT [] +synonym: "mandelic acid metabolic process" EXACT [] +synonym: "mandelic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:mca +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0018925 +name: m-cresol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl] +synonym: "3-hydroxytoluene metabolic process" EXACT [] +synonym: "3-hydroxytoluene metabolism" EXACT [] +synonym: "m-cresol metabolism" EXACT [] +synonym: "meta-cresol metabolic process" EXACT [] +synonym: "meta-cresol metabolism" EXACT [] +xref: MetaCyc:M-CRESOL-DEGRADATION-PWY +xref: UM-BBD_pathwayID:mcr +is_a: GO:0042212 ! cresol metabolic process + +[Term] +id: GO:0018926 +name: methanesulfonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa] +synonym: "methanesulfonic acid metabolism" EXACT [] +synonym: "methanesulphonic acid metabolic process" EXACT [] +synonym: "methanesulphonic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:msa +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0019694 ! alkanesulfonate metabolic process + +[Term] +id: GO:0018927 +name: obsolete methionine and threonine metabolic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule. +synonym: "methionine and threonine metabolic process" EXACT [] +is_obsolete: true +consider: GO:0006555 +consider: GO:0006566 + +[Term] +id: GO:0018928 +name: methyl ethyl ketone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [UM-BBD_pathwayID:mek] +synonym: "2-butanone metabolic process" EXACT [] +synonym: "2-butanone metabolism" EXACT [] +synonym: "MEK metabolic process" EXACT [] +synonym: "MEK metabolism" EXACT [] +synonym: "methyl ethyl ketone metabolism" EXACT [] +xref: UM-BBD_pathwayID:mek +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:0018929 +name: methyl fluoride metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf] +synonym: "methyl fluoride metabolism" EXACT [] +xref: UM-BBD_pathwayID:mf +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018930 +name: 3-methylquinoline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] +synonym: "3-methylquinoline metabolism" EXACT [] +xref: UM-BBD_pathwayID:mqn +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018933 +name: nicotine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +synonym: "nicotine metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0018934 +name: nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta] +synonym: "nitrilotriacetate metabolism" EXACT [] +xref: UM-BBD_pathwayID:nta +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018935 +name: aerobic nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai] +synonym: "aerobic nitrilotriacetate metabolism" EXACT [] +is_a: GO:0018934 ! nitrilotriacetate metabolic process + +[Term] +id: GO:0018936 +name: anaerobic nitrilotriacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic nitrilotriacetate metabolism" EXACT [] +is_a: GO:0018934 ! nitrilotriacetate metabolic process + +[Term] +id: GO:0018937 +name: nitroglycerin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [UM-BBD_pathwayID:ng] +synonym: "NG metabolic process" EXACT [] +synonym: "NG metabolism" EXACT [] +synonym: "nitroglycerin metabolism" EXACT [] +xref: MetaCyc:P201-PWY +xref: UM-BBD_pathwayID:ng +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018938 +name: 2-nitropropane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [UM-BBD_pathwayID:npp] +synonym: "2-nitropropane metabolism" EXACT [] +xref: MetaCyc:PWY-723 +xref: UM-BBD_pathwayID:npp +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018939 +name: n-octane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct] +synonym: "n-octane metabolism" EXACT [] +xref: UM-BBD_pathwayID:oct +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:0018940 +name: orcinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl] +synonym: "orcin metabolic process" EXACT [] +synonym: "orcin metabolism" EXACT [] +synonym: "orcinol metabolism" EXACT [] +xref: MetaCyc:P342-PWY +xref: UM-BBD_pathwayID:orc +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process + +[Term] +id: GO:0018941 +name: organomercury metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732] +synonym: "organomercury metabolism" EXACT [] +xref: UM-BBD_pathwayID:ogm +is_a: GO:0018942 ! organometal metabolic process + +[Term] +id: GO:0018942 +name: organometal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732] +subset: goslim_pir +synonym: "organometal metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018943 +name: organotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732] +synonym: "organotin metabolism" EXACT [] +is_a: GO:0018942 ! organometal metabolic process + +[Term] +id: GO:0018944 +name: tri-n-butyltin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt] +synonym: "tri-n-butyltin metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbt +is_a: GO:0018943 ! organotin metabolic process + +[Term] +id: GO:0018945 +name: organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl] +synonym: "organosilicon metabolism" EXACT [] +synonym: "organosilicone metabolic process" EXACT [] +synonym: "organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018946 +name: aerobic organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl] +synonym: "aerobic organosilicon metabolism" EXACT [] +synonym: "aerobic organosilicone metabolic process" EXACT [] +synonym: "aerobic organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018945 ! organosilicon metabolic process + +[Term] +id: GO:0018947 +name: anaerobic organosilicon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl] +synonym: "anaerobic organosilicon metabolism" EXACT [] +synonym: "anaerobic organosilicone metabolic process" EXACT [] +synonym: "anaerobic organosilicone metabolism" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018945 ! organosilicon metabolic process + +[Term] +id: GO:0018948 +name: xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl] +synonym: "xylene metabolism" EXACT [] +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0018949 +name: m-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +synonym: "m-xylene metabolism" EXACT [] +synonym: "meta-xylene metabolic process" EXACT [] +synonym: "meta-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:mxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018950 +name: o-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +synonym: "o-xylene metabolism" EXACT [] +synonym: "ortho-xylene metabolic process" EXACT [] +synonym: "ortho-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:oxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018951 +name: p-xylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +synonym: "p-xylene metabolism" EXACT [] +synonym: "para-xylene metabolic process" EXACT [] +synonym: "para-xylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pxy +is_a: GO:0018948 ! xylene metabolic process + +[Term] +id: GO:0018952 +name: parathion metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] +synonym: "parathion metabolism" EXACT [] +xref: UM-BBD_pathwayID:pthn +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process + +[Term] +id: GO:0018953 +name: p-cymene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy] +synonym: "p-cymene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pcy +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process + +[Term] +id: GO:0018954 +name: pentaerythritol tetranitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn] +synonym: "pentaerythritol tetranitrate metabolism" EXACT [] +xref: UM-BBD_pathwayID:petn +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018955 +name: phenanthrene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, UM-BBD_pathwayID:pha] +synonym: "phenanthrene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pha +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0018956 +name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha3] +synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] +synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] +xref: UM-BBD_pathwayID:pha3 +is_a: GO:0042216 ! phenanthrene catabolic process + +[Term] +id: GO:0018957 +name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha2] +synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] +synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] +xref: UM-BBD_pathwayID:pha2 +is_a: GO:0042216 ! phenanthrene catabolic process + +[Term] +id: GO:0018958 +name: phenol-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. +synonym: "carbolic acid metabolic process" EXACT [] +synonym: "carbolic acid metabolism" EXACT [] +synonym: "hydroxybenzene metabolic process" EXACT [] +synonym: "hydroxybenzene metabolism" EXACT [] +synonym: "phenol-containing compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0018959 +name: aerobic phenol-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [ISBN:0198506732] +synonym: "aerobic phenol-containing compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:pba +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0018960 +name: 4-nitrophenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl] +synonym: "4-nitrophenol metabolism" EXACT [] +synonym: "p-nitrophenol metabolic process" EXACT [] +synonym: "p-nitrophenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:nphe +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0018961 +name: pentachlorophenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [UM-BBD_pathwayID:pcp] +synonym: "PCP metabolic process" EXACT [] +synonym: "PCP metabolism" EXACT [] +synonym: "pentachlorophenol metabolism" EXACT [] +xref: UM-BBD_pathwayID:pcp +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018962 +name: 3-phenylpropionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa] +synonym: "3-phenylpropionate metabolism" EXACT [] +synonym: "hydrocinnamic acid metabolic process" EXACT [] +synonym: "hydrocinnamic acid metabolism" EXACT [] +synonym: "phenylpropanoate metabolic process" EXACT [] +synonym: "phenylpropanoate metabolism" EXACT [] +xref: UM-BBD_pathwayID:ppa +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018963 +name: phthalate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [UM-BBD_pathwayID:pth] +synonym: "phthalate metabolism" EXACT [] +synonym: "phthalic acid metabolic process" EXACT [] +synonym: "phthalic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:pth +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018964 +name: propylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl] +synonym: "propylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:pro +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:0018965 +name: s-triazine compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria] +synonym: "s-triazine compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:tria +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0018966 +name: styrene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, UM-BBD_pathwayID:sty] +synonym: "styrene metabolism" EXACT [] +xref: UM-BBD_pathwayID:sty +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0018967 +name: tetrachloroethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm] +synonym: "tetrachloroethene metabolic process" EXACT [] +synonym: "tetrachloroethene metabolism" EXACT [] +synonym: "tetrachloroethylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tce2 +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018968 +name: tetrahydrofuran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf] +synonym: "tetrahydrofuran metabolism" EXACT [] +synonym: "THF metabolic process" EXACT [] +synonym: "THF metabolism" EXACT [] +xref: UM-BBD_pathwayID:thf +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0097176 ! epoxide metabolic process + +[Term] +id: GO:0018969 +name: thiocyanate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl] +synonym: "thiocyanate metabolism" EXACT [] +synonym: "thiocyanic acid metabolic process" EXACT [] +synonym: "thiocyanic acid metabolism" EXACT [] +xref: MetaCyc:P581-PWY +xref: UM-BBD_pathwayID:thc +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0018970 +name: toluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [UM-BBD_pathwayID:tol] +synonym: "methylbenzene metabolic process" EXACT [] +synonym: "methylbenzene metabolism" EXACT [] +synonym: "toluene metabolism" EXACT [] +is_a: GO:0072490 ! toluene-containing compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0018971 +name: anaerobic toluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic toluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tol2 +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0018972 +name: toluene-4-sulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai] +synonym: "4-methylbenzenesulfonate metabolic process" EXACT [] +synonym: "4-methylbenzenesulfonate metabolism" EXACT [] +synonym: "4-toluenesulfonate metabolic process" EXACT [] +synonym: "4-toluenesulfonate metabolism" EXACT [] +synonym: "toluene-4-sulfonate metabolism" EXACT [] +synonym: "toluene-4-sulphonate metabolic process" EXACT [] +synonym: "toluene-4-sulphonate metabolism" EXACT [] +xref: MetaCyc:TOLSULFDEG-PWY +xref: UM-BBD_pathwayID:tsa +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process + +[Term] +id: GO:0018973 +name: trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +synonym: "trinitrotoluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tnt +is_a: GO:0019326 ! nitrotoluene metabolic process + +[Term] +id: GO:0018974 +name: 2,4,6-trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767] +synonym: "2,4,6-trinitrotoluene metabolism" EXACT [] +synonym: "TNT metabolic process" EXACT [] +synonym: "TNT metabolism" EXACT [] +is_a: GO:0018973 ! trinitrotoluene metabolic process + +[Term] +id: GO:0018975 +name: anaerobic 2,4,6-trinitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai] +synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tnt2 +is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process + +[Term] +id: GO:0018976 +name: 1,2,3-tribromopropane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl] +synonym: "1,2,3-tribromopropane metabolism" EXACT [] +xref: UM-BBD_pathwayID:tbp +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0018977 +name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] +synonym: "DDT metabolic process" EXACT [] +synonym: "DDT metabolism" EXACT [] +xref: UM-BBD_pathwayID:ddt +is_a: GO:0017143 ! insecticide metabolic process +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018978 +name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl] +synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] +synonym: "anaerobic DDT metabolic process" EXACT [] +synonym: "anaerobic DDT metabolism" EXACT [] +xref: UM-BBD_pathwayID:ddt2 +is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process + +[Term] +id: GO:0018979 +name: trichloroethylene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl] +synonym: "TCE metabolic process" EXACT [] +synonym: "TCE metabolism" EXACT [] +synonym: "trichloroethene metabolic process" EXACT [] +synonym: "trichloroethene metabolism" EXACT [] +synonym: "trichloroethylene metabolism" EXACT [] +xref: UM-BBD_pathwayID:tce +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0018980 +name: 2,4,5-trichlorophenoxyacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t] +synonym: "2,4,5-T metabolic process" EXACT [] +synonym: "2,4,5-T metabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] +xref: UM-BBD_pathwayID:2\,4\,5-t +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018981 +name: triethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl] +synonym: "triethanolamine metabolism" EXACT [] +xref: UM-BBD_pathwayID:tea +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0044106 ! cellular amine metabolic process +is_a: GO:0044107 ! cellular alcohol metabolic process + +[Term] +id: GO:0018982 +name: vanillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl] +synonym: "vanillic aldehyde metabolic process" EXACT [] +synonym: "vanillic aldehyde metabolism" EXACT [] +synonym: "vanillin metabolism" EXACT [] +xref: UM-BBD_pathwayID:van +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0018983 +name: Z-phenylacetaldoxime metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car] +synonym: "Z-phenylacetaldoxime metabolism" EXACT [] +xref: UM-BBD_pathwayID:pao +is_a: GO:0019330 ! aldoxime metabolic process + +[Term] +id: GO:0018984 +name: naphthalenesulfonate metabolic process +namespace: biological_process +alt_id: GO:0018932 +def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai] +synonym: "naphthalenesulfonate metabolism" EXACT [] +synonym: "naphthalenesulphonate metabolic process" EXACT [] +synonym: "naphthalenesulphonate metabolism" EXACT [] +xref: UM-BBD_pathwayID:nphs +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0018985 +name: pronuclear envelope synthesis +namespace: biological_process +def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems] +is_a: GO:0006998 ! nuclear envelope organization +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0018988 +name: obsolete molting cycle, protein-based cuticle +namespace: biological_process +def: "OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu] +comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. +synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0007591 +consider: GO:0018996 + +[Term] +id: GO:0018989 +name: apolysis +namespace: biological_process +def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl] +xref: Wikipedia:Apolysis +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0018990 +name: ecdysis, chitin-based cuticle +namespace: biological_process +def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0018991 +name: oviposition +namespace: biological_process +alt_id: GO:0060403 +def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] +synonym: "egg laying" BROAD [] +synonym: "egg-laying" BROAD [] +synonym: "post-mating oviposition" NARROW [] +xref: Wikipedia:Oviposition +is_a: GO:0019098 ! reproductive behavior + +[Term] +id: GO:0018992 +name: germ-line sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0018993 +name: somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0018995 +name: host cellular component +namespace: cellular_component +def: "Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] +synonym: "host organism" EXACT [] +xref: Wikipedia:Host_(biology) +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0018996 +name: molting cycle, collagen and cuticulin-based cuticle +namespace: biological_process +def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] +synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0018997 +name: obsolete electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because the parent terms cover its function. +synonym: "electron transfer carrier" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0018998 +name: obsolete metaxin +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a single gene product and not a complex. +synonym: "metaxin" EXACT [] +is_obsolete: true +consider: GO:0005741 + +[Term] +id: GO:0019000 +name: obsolete endonuclease G activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691] +comment: This term was made obsolete because it represents a gene product. +synonym: "endonuclease G activity" EXACT [] +is_obsolete: true +consider: GO:0004520 +consider: GO:0004521 + +[Term] +id: GO:0019001 +name: guanyl nucleotide binding +namespace: molecular_function +def: "Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] +xref: Reactome:R-HSA-156909 "eEF1A complexes with GTP" +is_a: GO:0017076 ! purine nucleotide binding + +[Term] +id: GO:0019002 +name: GMP binding +namespace: molecular_function +def: "Binding to GMP, guanosine monophosphate." [GOC:ai] +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0019003 +name: GDP binding +namespace: molecular_function +def: "Binding to GDP, guanosine 5'-diphosphate." [GOC:ai] +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0019005 +name: SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "CDL1 complex" EXACT [] +synonym: "CRL1 complex" EXACT [] +synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] +synonym: "cullin-RING ligase 1" EXACT [] +synonym: "SCF complex" EXACT [] +synonym: "SCF complex substrate recognition subunit" NARROW [] +synonym: "Skp1/Cul1/F-box protein complex" EXACT [] +xref: Wikipedia:SCF_complex +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0019008 +name: molybdopterin synthase complex +namespace: cellular_component +alt_id: GO:0019009 +def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] +subset: goslim_metagenomics +synonym: "molybdopterin converting factor complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0019010 +name: farnesoic acid O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] +synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0019011 +name: obsolete DNA replication accessory factor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +synonym: "DNA replication accessory factor" EXACT [] +is_obsolete: true +consider: GO:0006260 + +[Term] +id: GO:0019013 +name: viral nucleocapsid +namespace: cellular_component +alt_id: GO:0019014 +def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] +subset: goslim_chembl +synonym: "core" BROAD [] +synonym: "nucleocapsid" EXACT [] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0019015 +name: obsolete viral genome +namespace: cellular_component +def: "OBSOLETE. The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019016 +name: obsolete non-segmented viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019017 +name: obsolete segmented viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019018 +name: obsolete bipartite viral genome +namespace: cellular_component +def: "OBSOLETE. A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019019 +name: obsolete tripartite viral genome +namespace: cellular_component +def: "OBSOLETE. A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019020 +name: obsolete multipartite viral genome +namespace: cellular_component +def: "OBSOLETE. A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019021 +name: obsolete DNA viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019022 +name: obsolete RNA viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019023 +name: obsolete dsRNA viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome composed of double stranded RNA." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019024 +name: obsolete ssRNA viral genome +namespace: cellular_component +def: "OBSOLETE. A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019025 +name: obsolete positive sense viral genome +namespace: cellular_component +def: "OBSOLETE. A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019026 +name: obsolete negative sense viral genome +namespace: cellular_component +def: "OBSOLETE. A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019027 +name: obsolete ambisense viral genome +namespace: cellular_component +def: "OBSOLETE. A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +is_obsolete: true + +[Term] +id: GO:0019028 +name: viral capsid +namespace: cellular_component +alt_id: GO:0046728 +def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] +subset: goslim_chembl +xref: Wikipedia:Capsid +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0019029 +name: helical viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885] +is_a: GO:0019028 ! viral capsid + +[Term] +id: GO:0019030 +name: icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure." [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid] +synonym: "quasispherical viral capsid" EXACT [] +is_a: GO:0019028 ! viral capsid + +[Term] +id: GO:0019031 +name: viral envelope +namespace: cellular_component +def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] +subset: goslim_chembl +synonym: "viral glycoprotein" RELATED [] +synonym: "viral outside membrane" EXACT [] +xref: Wikipedia:Viral_envelope +is_a: GO:0036338 ! viral membrane + +[Term] +id: GO:0019032 +name: obsolete viral glycoprotein +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a type of gene product and not a location or complex. +synonym: "viral glycoprotein" EXACT [] +is_obsolete: true +consider: GO:0019031 + +[Term] +id: GO:0019033 +name: viral tegument +namespace: cellular_component +def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544] +xref: Wikipedia:Viral_tegument +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0019034 +name: viral replication complex +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] +is_a: GO:0044094 ! host cell nuclear part + +[Term] +id: GO:0019035 +name: viral integration complex +namespace: cellular_component +def: "A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins." [PMID:21037296, PMID:2721960, PMID:29900498] +synonym: "PIC" BROAD [] +synonym: "pre-integration complex" EXACT [] +xref: Wikipedia:Pre-integration_complex +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0043657 ! host cell + +[Term] +id: GO:0019036 +name: viral transcriptional complex +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0019037 +name: viral assembly intermediate +namespace: cellular_component +def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0019038 +name: obsolete provirus +namespace: cellular_component +def: "OBSOLETE. The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] +comment: This term was obsoleted because it does not represent a GO cellular component. +xref: Wikipedia:Provirus +is_obsolete: true + +[Term] +id: GO:0019039 +name: obsolete viral-cell fusion molecule activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "viral-cell fusion molecule activity" EXACT [] +is_obsolete: true +consider: GO:0019064 +consider: GO:0050839 + +[Term] +id: GO:0019040 +name: obsolete viral host shutoff protein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "viral host shutoff protein" EXACT [] +is_obsolete: true +consider: GO:0004534 +consider: GO:0019057 + +[Term] +id: GO:0019042 +name: viral latency +namespace: biological_process +alt_id: GO:0030069 +alt_id: GO:0075710 +def: "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl] +synonym: "latent virus infection" EXACT [] +synonym: "phage lysogeny" EXACT [] +synonym: "viral dormancy" EXACT [] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0019043 +name: establishment of viral latency +namespace: biological_process +alt_id: GO:0075601 +def: "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects." [GOC:jl] +synonym: "lysogenic commitment" EXACT [] +synonym: "phage lysogeny" NARROW [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019042 ! viral latency + +[Term] +id: GO:0019044 +name: maintenance of viral latency +namespace: biological_process +alt_id: GO:0032360 +alt_id: GO:0075716 +def: "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms." [GOC:jl] +synonym: "latent virus maintenance" EXACT [] +synonym: "prophage maintenance" EXACT [] +synonym: "provirus maintenance" EXACT [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019042 ! viral latency + +[Term] +id: GO:0019045 +name: latent virus replication +namespace: biological_process +def: "Any process required for latent viral replication in a cell." [ISBN:0781702534] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019042 ! viral latency + +[Term] +id: GO:0019046 +name: release from viral latency +namespace: biological_process +alt_id: GO:0075717 +def: "The process by which a virus begins to replicate following a latency replication decision (switch)." [GOC:dos, GOC:jl] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019045 ! latent virus replication + +[Term] +id: GO:0019048 +name: modulation by virus of host process +namespace: biological_process +alt_id: GO:0044661 +alt_id: GO:0044792 +def: "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945] +synonym: "disruption by virus of host cell" RELATED [] +synonym: "host-virus interaction" EXACT [GOC:bf, GOC:jl] +synonym: "modulation by virus of host anatomical structure or process" RELATED [GOC:bf, GOC:jl] +synonym: "modulation by virus of host anatomy or process" EXACT [GOC:bf, GOC:jl] +synonym: "modulation by virus of host morphology or physiology" RELATED [] +synonym: "viral interaction with host" EXACT [] +synonym: "viral-host process" EXACT [GOC:bf, GOC:jl] +synonym: "virus-host interaction" BROAD [GOC:bf, GOC:jl] +synonym: "virus-host process" EXACT [GOC:bf, GOC:jl] +xref: VZ:886 "Vertebrate host-virus interactions" +is_a: GO:0016032 ! viral process +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0019049 +name: mitigation of host defenses by virus +namespace: biological_process +def: "A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272] +synonym: "evasion of host defenses by virus" NARROW [GOC:bf, GOC:bm, GOC:jl] +synonym: "evasion or tolerance of host defenses by virus" RELATED [] +synonym: "viral host defence evasion" NARROW [] +synonym: "viral host defense evasion" NARROW [] +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0030682 ! mitigation of host defenses by symbiont + +[Term] +id: GO:0019050 +name: suppression by virus of host apoptotic process +namespace: biological_process +def: "Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication." [GOC:mtg_apoptosis, ISBN:0781718325] +synonym: "negative regulation by virus of host apoptosis" EXACT [] +synonym: "negative regulation of apoptosis by virus" EXACT [] +synonym: "suppression by virus of host apoptosis" EXACT [] +synonym: "suppression of apoptosis in host by virus" EXACT [] +is_a: GO:0033668 ! negative regulation by symbiont of host apoptotic process +is_a: GO:0039526 ! modulation by virus of host apoptotic process + +[Term] +id: GO:0019051 +name: induction by virus of host apoptotic process +namespace: biological_process +def: "The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions." [GOC:mtg_apoptosis, ISBN:0781718325] +synonym: "activation by virus of host apoptosis" EXACT [] +synonym: "activation by virus of host apoptotic programmed cell death" EXACT [] +synonym: "activation of apoptosis in host by virus" EXACT [] +synonym: "induction by virus of host apoptosis" NARROW [] +synonym: "induction by virus of host apoptotic programmed cell death" EXACT [] +synonym: "induction of apoptosis in host by virus" EXACT [] +is_a: GO:0060139 ! positive regulation of apoptotic process by virus + +[Term] +id: GO:0019054 +name: modulation by virus of host cellular process +namespace: biological_process +def: "The process in which a virus effects a change in the processes and activities of its host organism." [GOC:jl] +synonym: "modification by virus of host cellular process" EXACT [] +synonym: "modulation by virus of host process" BROAD [] +synonym: "modulation of cellular process in host by virus" RELATED [] +synonym: "regulation by virus of host cellular process" EXACT [] +synonym: "regulation of cellular process in host by virus" EXACT [] +synonym: "regulation of host cellular process by virus" EXACT [] +synonym: "viral host cell process manipulation" EXACT [] +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0044068 ! modulation by symbiont of host cellular process + +[Term] +id: GO:0019055 +name: modification by virus of host cell cycle regulation +namespace: biological_process +def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325] +synonym: "viral perturbation of cell cycle regulation" EXACT [] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0044071 ! modulation by symbiont of host cell cycle + +[Term] +id: GO:0019056 +name: modulation by virus of host transcription +namespace: biological_process +def: "Any process in which a virus modulates the frequency, rate or extent of its host's transcription." [ISBN:0781718325] +synonym: "modification by virus of host transcription" EXACT [] +synonym: "viral perturbation of host cell transcription" EXACT [] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0039656 ! modulation by virus of host gene expression +is_a: GO:0052026 ! modulation by symbiont of host transcription + +[Term] +id: GO:0019057 +name: modulation by virus of host translation +namespace: biological_process +def: "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325] +synonym: "host cell protein synthesis shutoff" BROAD [] +synonym: "host cell shutoff" BROAD [] +synonym: "modification by virus of host cell mRNA translation" EXACT [] +synonym: "modulation of host translation by virus" EXACT [GOC:bf] +synonym: "regulation of host mRNA translation by virus" EXACT [] +synonym: "regulation of host translation by virus" EXACT [] +synonym: "regulation of translation in host by virus" EXACT [] +synonym: "viral host shutoff protein" RELATED [] +synonym: "viral perturbation of host cell mRNA translation" EXACT [] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0039656 ! modulation by virus of host gene expression +is_a: GO:0044073 ! modulation by symbiont of host translation + +[Term] +id: GO:0019058 +name: viral life cycle +namespace: biological_process +alt_id: GO:0019067 +def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] +synonym: "lytic viral life cycle" RELATED [] +synonym: "viral assembly, maturation, egress, and release" NARROW [GOC:bf, GOC:jl] +synonym: "viral infectious cycle" RELATED [GOC:bf, GOC:jl] +synonym: "viral replication" RELATED [GOC:bf, GOC:jl] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0019059 +name: obsolete initiation of viral infection +namespace: biological_process +def: "OBSOLETE. The set of processes involved in the start of virus infection of cells." [ISBN:0781702534] +comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. +synonym: "initiation of viral infection" EXACT [] +is_obsolete: true +consider: GO:0046718 + +[Term] +id: GO:0019060 +name: intracellular transport of viral protein in host cell +namespace: biological_process +alt_id: GO:0046742 +alt_id: GO:0046743 +alt_id: GO:0046801 +def: "The directed movement of a viral protein within the host cell." [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566] +comment: This term is for annotation of proteins responsible for the movement of individual viral proteins, rather than the whole viral particle. +synonym: "cytoplasmic viral capsid transport" NARROW [] +synonym: "intracellular transport of viral capsid in host cell" NARROW [] +synonym: "intracellular transport of viral capsid protein in host cell" NARROW [] +synonym: "intracellular transport of viral proteins in host cell" EXACT [] +synonym: "intracellular viral capsid transport" NARROW [] +synonym: "intracellular viral protein transport" EXACT [] +synonym: "nuclear viral capsid transport" NARROW [] +synonym: "viral capsid transport in host cell cytoplasm" NARROW [] +synonym: "viral capsid transport in host cell nucleus" NARROW [] +is_a: GO:0030581 ! symbiont intracellular protein transport in host +relationship: part_of GO:0046719 ! regulation by virus of viral protein levels in host cell + +[Term] +id: GO:0019061 +name: uncoating of virus +namespace: biological_process +def: "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome." [GOC:plm, ISBN:0781702534, PMID:8162442] +synonym: "viral uncoating" EXACT [PMID:8162442] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0019062 +name: virion attachment to host cell +namespace: biological_process +def: "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956] +synonym: "viral absorption" EXACT [] +synonym: "viral attachment to host cell" RELATED [GOC:bf, GOC:jl] +synonym: "virion attachment to host cell surface receptor" NARROW [] +xref: VZ:956 "Viral attachment to host cell" +is_a: GO:0044650 ! adhesion of symbiont to host cell +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0019064 +name: fusion of virus membrane with host plasma membrane +namespace: biological_process +alt_id: GO:0075706 +def: "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm." [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:bf, GOC:jl] +synonym: "viral envelope fusion" BROAD [] +synonym: "viral envelope fusion with host cell membrane" EXACT [] +synonym: "viral envelope fusion with host membrane" EXACT [] +synonym: "viral envelope fusion with host plasma membrane" EXACT [] +synonym: "viral penetration via membrane fusion" BROAD [] +synonym: "viral-cell fusion molecule activity" RELATED [] +xref: VZ:987 "Fusion of virus membrane with host cell membrane" +is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell +is_a: GO:0061025 ! membrane fusion + +[Term] +id: GO:0019065 +name: receptor-mediated endocytosis of virus by host cell +namespace: biological_process +def: "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:bf, GOC:jl, ISBN:0781702534] +synonym: "receptor mediated endocytosis by host of virus particle" EXACT [] +synonym: "receptor mediated endocytosis of virus by host" EXACT [] +synonym: "receptor mediated endocytosis of virus particle by host" EXACT [] +synonym: "receptor-mediated endocytosis of virus by host" EXACT [] +synonym: "viral entry into host cell via receptor-mediated endocytosis" RELATED [GOC:bf, GOC:jl] +synonym: "viral receptor mediated endocytosis" EXACT [] +synonym: "virus receptor-mediated endocytosis by host" EXACT [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0075509 ! endocytosis involved in viral entry into host cell + +[Term] +id: GO:0019066 +name: obsolete translocation of virus into host cell +namespace: biological_process +def: "OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534] +comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. +synonym: "translocation of virus into host cell" EXACT [] +synonym: "viral translocation" EXACT [] +is_obsolete: true +replaced_by: GO:0046718 + +[Term] +id: GO:0019068 +name: virion assembly +namespace: biological_process +alt_id: GO:0042963 +def: "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336] +synonym: "bacteriophage assembly" NARROW [GOC:bm] +synonym: "phage assembly" NARROW [GOC:bm] +synonym: "viral assembly" EXACT [] +synonym: "viral particle assembly" EXACT [] +synonym: "virion assembly and maintenance" EXACT [GOC:bf, GOC:jl] +synonym: "virion organization" EXACT [GOC:bf, GOC:jl] +synonym: "virus assembly" EXACT [GOC:dph, GOC:tb] +synonym: "virus particle assembly" EXACT [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0019069 +name: viral capsid assembly +namespace: biological_process +def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, UniProtKB-KW:KW-0118] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0019070 +name: viral genome maturation +namespace: biological_process +def: "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes." [GOC:pk, PMID:21490093] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0019071 +name: viral DNA cleavage involved in viral genome maturation +namespace: biological_process +def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336] +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis +relationship: part_of GO:0019070 ! viral genome maturation + +[Term] +id: GO:0019072 +name: viral genome packaging +namespace: biological_process +def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0019073 +name: viral DNA genome packaging +namespace: biological_process +def: "The packing of viral DNA into a capsid." [ISBN:0781702534] +is_a: GO:0019072 ! viral genome packaging + +[Term] +id: GO:0019074 +name: viral RNA genome packaging +namespace: biological_process +def: "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid." [ISBN:0781718325] +is_a: GO:0019072 ! viral genome packaging + +[Term] +id: GO:0019075 +name: virus maturation +namespace: biological_process +def: "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release." [ISBN:0781718325] +synonym: "bacteriophage maturation" NARROW [PMID:22308333] +synonym: "viral maturation" EXACT [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0019076 +name: viral release from host cell +namespace: biological_process +def: "The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl] +synonym: "release of virus from host" EXACT [] +synonym: "viral exit" EXACT [] +synonym: "viral release" EXACT [] +synonym: "viral shedding" EXACT [] +synonym: "virus exit from host cell" EXACT [GOC:bf, GOC:jl] +xref: VZ:1076 "Virus exit from host cell" +is_a: GO:0016032 ! viral process +is_a: GO:0035891 ! exit from host cell +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0019078 +name: obsolete lytic viral budding +namespace: biological_process +def: "OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534] +comment: This term was made obsolete because it does not appear to correspond to a real biological process. +synonym: "lytic viral budding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019079 +name: viral genome replication +namespace: biological_process +def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] +synonym: "sigma virus replication" NARROW [] +synonym: "viral replication" BROAD [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0019080 +name: viral gene expression +namespace: biological_process +def: "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation." [GOC:bf, GOC:jl, ISBN:0121585336] +synonym: "viral genome expression" EXACT [GOC:jl] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0019081 +name: viral translation +namespace: biological_process +def: "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534] +synonym: "viral protein anabolism" EXACT [] +synonym: "viral protein biosynthesis" EXACT [] +synonym: "viral protein biosynthetic process" EXACT [ISBN:0781702534] +synonym: "viral protein formation" EXACT [] +synonym: "viral protein synthesis" EXACT [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019080 ! viral gene expression + +[Term] +id: GO:0019082 +name: viral protein processing +namespace: biological_process +def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein." [GOC:bf, GOC:jl, ISBN:0781702534] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019080 ! viral gene expression + +[Term] +id: GO:0019083 +name: viral transcription +namespace: biological_process +def: "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell." [GOC:jl, ISBN:0781702534] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019080 ! viral gene expression + +[Term] +id: GO:0019084 +name: middle viral transcription +namespace: biological_process +def: "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication." [GOC:bf, GOC:jl] +synonym: "(delayed) early viral mRNA transcription" RELATED [GOC:jh2] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019085 +name: early viral transcription +namespace: biological_process +def: "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." [GOC:bf, GOC:jh2, GOC:jl] +synonym: "immediate early viral mRNA transcription" RELATED [] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019086 +name: late viral transcription +namespace: biological_process +def: "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins." [GOC:bf, GOC:jh2, GOC:jl] +synonym: "late viral mRNA transcription" RELATED [] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0019087 +name: transformation of host cell by virus +namespace: biological_process +alt_id: GO:0019088 +alt_id: GO:0020021 +def: "A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication." [ISBN:0781702534, PMID:11119620, PMID:18366075, PMID:24373315] +synonym: "host cell immortalization" EXACT [] +synonym: "host cell transformation" EXACT [] +synonym: "immortalization of host cell" EXACT [] +synonym: "immortalization of host cell by virus" RELATED [] +synonym: "transformation of host cell" EXACT [] +synonym: "viral immortalization" EXACT [] +synonym: "viral transformation" EXACT [] +synonym: "viral transformation of host cell" EXACT [] +xref: Wikipedia:Viral_transformation +is_a: GO:0019048 ! modulation by virus of host process + +[Term] +id: GO:0019089 +name: obsolete transmission of virus +namespace: biological_process +def: "OBSOLETE. The transfer of virions in order to create new infection." [ISBN:0781702534] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a virus. +synonym: "viral transmission" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019090 +name: mitochondrial rRNA export from mitochondrion +namespace: biological_process +def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai, PMID:28115039] +synonym: "export of mitochondrial rRNA" BROAD [] +synonym: "mitochondrial rRNA export" EXACT [] +synonym: "mitochondrial rRNA export from mitochondria" EXACT [] +synonym: "mitochondrial rRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial rRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial rRNA, mitochondrial export" EXACT [] +is_a: GO:0051029 ! rRNA transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0019091 +name: mitochondrial lrRNA export from mitochondrion +namespace: biological_process +def: "The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] +synonym: "export of mitochondrial lrRNA" BROAD [] +synonym: "mitochondrial lrRNA export" EXACT [] +synonym: "mitochondrial lrRNA export from mitochondria" EXACT [] +synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial lrRNA, mitochondrial export" EXACT [] +is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion + +[Term] +id: GO:0019092 +name: mitochondrial srRNA export from mitochondrion +namespace: biological_process +def: "The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] +synonym: "export of mitochondrial srRNA" BROAD [] +synonym: "mitochondrial srRNA export" EXACT [] +synonym: "mitochondrial srRNA export from mitochondria" EXACT [] +synonym: "mitochondrial srRNA export out of mitochondrion" EXACT [] +synonym: "mitochondrial srRNA transport from mitochondrion" EXACT [] +synonym: "mitochondrial srRNA, mitochondrial export" EXACT [] +is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion + +[Term] +id: GO:0019093 +name: mitochondrial RNA localization +namespace: biological_process +def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] +synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] +synonym: "mtRNA localization" EXACT [] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0019094 +name: pole plasm mRNA localization +namespace: biological_process +alt_id: GO:0048120 +def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] +synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT [] +synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT [] +synonym: "oocyte pole plasm mRNA localization" EXACT [] +synonym: "pole granule RNA localization" BROAD [] +synonym: "pole plasm mRNA localisation" EXACT [GOC:mah] +is_a: GO:0007316 ! pole plasm RNA localization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification + +[Term] +id: GO:0019095 +name: pole plasm mitochondrial rRNA localization +namespace: biological_process +alt_id: GO:0048117 +def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT [] +synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah] +is_a: GO:0007316 ! pole plasm RNA localization +is_a: GO:0019093 ! mitochondrial RNA localization + +[Term] +id: GO:0019096 +name: pole plasm mitochondrial lrRNA localization +namespace: biological_process +alt_id: GO:0048118 +def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT [] +synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah] +is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization + +[Term] +id: GO:0019097 +name: pole plasm mitochondrial srRNA localization +namespace: biological_process +alt_id: GO:0048119 +def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] +synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT [] +synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT [] +synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah] +is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization + +[Term] +id: GO:0019098 +name: reproductive behavior +namespace: biological_process +alt_id: GO:0033057 +alt_id: GO:0044704 +alt_id: GO:0044705 +def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] +synonym: "multi-organism reproductive behavior" NARROW [] +synonym: "multicellular organism reproductive behavior" NARROW [] +synonym: "reproductive behavior in a multicellular organism" EXACT [] +synonym: "reproductive behaviour" EXACT [] +synonym: "single-organism reproductive behavior" RELATED [] +is_a: GO:0007610 ! behavior +is_a: GO:0048609 ! multicellular organismal reproductive process + +[Term] +id: GO:0019099 +name: female germ-line sex determination +namespace: biological_process +alt_id: GO:0007544 +def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] +synonym: "sex determination, female germ-line determination" EXACT [] +is_a: GO:0007542 ! primary sex determination, germ-line +is_a: GO:0018992 ! germ-line sex determination +is_a: GO:0030237 ! female sex determination + +[Term] +id: GO:0019100 +name: male germ-line sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] +is_a: GO:0007542 ! primary sex determination, germ-line +is_a: GO:0018992 ! germ-line sex determination +is_a: GO:0030238 ! male sex determination + +[Term] +id: GO:0019101 +name: female somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] +is_a: GO:0018993 ! somatic sex determination +is_a: GO:0030237 ! female sex determination + +[Term] +id: GO:0019102 +name: male somatic sex determination +namespace: biological_process +def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] +is_a: GO:0018993 ! somatic sex determination +is_a: GO:0030238 ! male sex determination + +[Term] +id: GO:0019103 +name: pyrimidine nucleotide binding +namespace: molecular_function +def: "Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0019104 +name: DNA N-glycosylase activity +namespace: molecular_function +alt_id: GO:0008578 +def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] +synonym: "DNA glycosylase activity" EXACT [] +synonym: "endonuclease VIII activity" RELATED [] +xref: Reactome:R-HSA-110218 "Cleavage of uracil by TDG glycosylase" +xref: Reactome:R-HSA-110219 "Cleavage of thymine by TDG glycosylase" +xref: Reactome:R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase" +xref: Reactome:R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase" +xref: Reactome:R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase" +xref: Reactome:R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH" +xref: Reactome:R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase" +xref: Reactome:R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase" +xref: Reactome:R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase" +xref: Reactome:R-HSA-5220959 "TDG excises 5-formylcytosine" +xref: Reactome:R-HSA-5221061 "TDG excises 5-carboxylcytosine" +xref: Reactome:R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA" +xref: Reactome:R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA" +xref: Reactome:R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA" +xref: Reactome:R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA" +xref: Reactome:R-HSA-9629149 "NEIL1 cleaves thymine glycol from damaged DNA" +xref: Reactome:R-HSA-9629216 "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA" +xref: Reactome:R-HSA-9629470 "NEIL3 cleaves 5-guanidinohydantoin" +xref: Reactome:R-HSA-9629483 "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA" +xref: Reactome:R-HSA-9629492 "NEIL3 cleaves spiroiminodihydantoin" +xref: Reactome:R-HSA-9629497 "NEIL3 cleaves thymine glycol from telomeric DNA" +xref: Reactome:R-HSA-9629499 "NEIL3 cleaves thymine glycol" +xref: Reactome:R-HSA-9635996 "NEIL3 resolves psoralen-induced ICLs" +xref: Reactome:R-HSA-9636008 "NEIL3 resolves abasic site-induced ICLs" +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0019105 +name: N-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016409 ! palmitoyltransferase activity +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0019107 +name: myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] +xref: Reactome:R-HSA-141367 "Myristoylation of tBID by NMT1" +xref: Reactome:R-HSA-162914 "Myristoylation of Nef" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0019108 +name: aryl-aldehyde dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] +synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.29] +xref: EC:1.2.1.29 +xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:11804 +xref: UM-BBD_reactionID:r0394 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0019111 +name: phenanthrol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] +synonym: "phenanthrol sulphotransferase activity" EXACT [] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0019112 +name: phenanthrol glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0019113 +name: limonene monooxygenase activity +namespace: molecular_function +def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah, PMID:820855] +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0019114 +name: catechol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN] +xref: EC:1.13.11.- +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0019115 +name: benzaldehyde dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] +xref: EC:1.2.1.- +is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0019116 +name: hydroxy-nicotine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, http://umbbd.ahc.umn.edu/] +xref: EC:1.5.3.6 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0019117 +name: dihydroxyfluorene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422] +xref: EC:1.13.11.- +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0019118 +name: phenanthrene-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] +xref: EC:3.3.2.- +is_a: GO:0004301 ! epoxide hydrolase activity + +[Term] +id: GO:0019119 +name: phenanthrene-9,10-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] +is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity + +[Term] +id: GO:0019120 +name: hydrolase activity, acting on acid halide bonds, in C-halide compounds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732] +xref: EC:3.8.1.- +xref: Reactome:R-HSA-9011595 "GSTZ1 dimer dehalogenates DCA to glyoxylate" +is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds + +[Term] +id: GO:0019121 +name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218] +xref: RESID:AA0218 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0019122 +name: peptidyl-D-alanine racemization +namespace: biological_process +def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191] +comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. +synonym: "alanine racemization" BROAD [] +xref: RESID:AA0191 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0019123 +name: peptidyl-methionine racemization +namespace: biological_process +alt_id: GO:0018087 +alt_id: GO:0018369 +def: "The racemization of peptidyl-methionine." [RESID:AA0193] +xref: RESID:AA0193 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019124 +name: peptidyl-isoleucine racemization +namespace: biological_process +alt_id: GO:0018088 +alt_id: GO:0018370 +def: "The racemization of peptidyl-isoleucine." [RESID:AA0192] +xref: RESID:AA0192 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019125 +name: peptidyl-phenylalanine racemization +namespace: biological_process +alt_id: GO:0018089 +alt_id: GO:0018371 +def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194] +xref: RESID:AA0194 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019126 +name: peptidyl-serine racemization +namespace: biological_process +alt_id: GO:0018090 +alt_id: GO:0018372 +def: "The racemization of peptidyl-serine." [RESID:AA0195] +xref: RESID:AA0195 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019128 +name: peptidyl-tryptophan racemization +namespace: biological_process +alt_id: GO:0018092 +alt_id: GO:0018374 +def: "The racemization of peptidyl-tryptophan." [RESID:AA0198] +xref: RESID:AA0198 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019129 +name: peptidyl-leucine racemization +namespace: biological_process +alt_id: GO:0018093 +alt_id: GO:0018375 +def: "The racemization of peptidyl-leucine." [RESID:AA0197] +xref: RESID:AA0197 +is_a: GO:0018085 ! peptidyl-L-amino acid racemization + +[Term] +id: GO:0019131 +name: obsolete tripeptidyl-peptidase I activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] +comment: This term was made obsolete because it represents a gene product. +synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] +synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] +synonym: "tripeptidyl-peptidase I activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008240 + +[Term] +id: GO:0019132 +name: obsolete C-terminal processing peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "C-terminal processing peptidase activity" EXACT [] +synonym: "CtpA gene product (Synechocystis sp.)" RELATED [] +synonym: "photosystem II D1 protein processing peptidase" NARROW [] +synonym: "protease Re" RELATED [] +synonym: "tail-specific protease activity" RELATED [] +synonym: "Tsp protease" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0019133 +name: choline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] +synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" RELATED [EC:1.14.15.7] +xref: EC:1.14.15.7 +xref: MetaCyc:RXN1F-357 +xref: RHEA:17769 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0019134 +name: glucosamine-1-phosphate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13725] +synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.157] +synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" RELATED [EC:2.3.1.157] +xref: EC:2.3.1.157 +xref: KEGG_REACTION:R05332 +xref: MetaCyc:2.3.1.157-RXN +xref: RHEA:13725 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0019135 +name: deoxyhypusine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] +synonym: "deoxyhypusine dioxygenase activity" RELATED [EC:1.14.99.29] +synonym: "deoxyhypusine hydroxylase activity" EXACT [] +synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.99.29] +synonym: "DOHH activity" RELATED [EC:1.14.99.29] +xref: EC:1.14.99.29 +xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A" +xref: RHEA:14101 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0019136 +name: deoxynucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] +synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.145] +synonym: "D. melanogaster deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] +synonym: "Dm-dNK" RELATED [EC:2.7.1.145] +synonym: "ms-dNK" RELATED [EC:2.7.1.145] +synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] +synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] +synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] +synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] +xref: EC:2.7.1.145 +xref: MetaCyc:2.7.1.145-RXN +xref: RHEA:12140 +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0019137 +name: thioglucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] +synonym: "myrosinase activity" EXACT [] +synonym: "sinigrase activity" EXACT [] +synonym: "sinigrinase activity" EXACT [] +synonym: "thioglucoside glucohydrolase activity" EXACT [] +xref: EC:3.2.1.147 +xref: MetaCyc:RXN-9946 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0019139 +name: cytokinin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0046420 +def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.12] +synonym: "cytokinin oxidase activity" RELATED [] +synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" RELATED [EC:1.5.99.12] +synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.12] +xref: EC:1.5.99.12 +xref: MetaCyc:1.5.99.12-RXN +xref: MetaCyc:PWY-2841 +xref: RHEA:13625 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0019140 +name: inositol 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] +synonym: "ATP:myo-inositol 1-phosphotransferase activity" RELATED [EC:2.7.1.64] +synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] +synonym: "inositol-1-kinase (phosphorylating)" RELATED [EC:2.7.1.64] +synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] +synonym: "myo-inositol 3-kinase activity" EXACT [] +synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] +xref: EC:2.7.1.64 +xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN +xref: RHEA:21804 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0019141 +name: 2-dehydropantolactone reductase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] +synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" RELATED [EC:1.1.1.214] +synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] +synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] +synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] +synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] +xref: EC:1.1.1.214 +xref: MetaCyc:DEHYDROPANTLACRED-RXN +is_a: GO:0036441 ! 2-dehydropantolactone reductase activity + +[Term] +id: GO:0019142 +name: 2-hydroxyglutarate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)." [EC:2.3.3.11, RHEA:19185] +comment: Note that this function was formerly EC:4.1.3.9. +synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" RELATED [EC:2.3.3.11] +synonym: "2-hydroxyglutaratic synthetase activity" RELATED [EC:2.3.3.11] +synonym: "2-hydroxyglutaric synthetase activity" RELATED [EC:2.3.3.11] +synonym: "alpha-hydroxyglutarate synthase activity" RELATED [EC:2.3.3.11] +synonym: "hydroxyglutarate synthase activity" RELATED [EC:2.3.3.11] +synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" RELATED [EC:2.3.3.11] +xref: EC:2.3.3.11 +xref: KEGG_REACTION:R00932 +xref: MetaCyc:HYDGLUTSYN-RXN +xref: RHEA:19185 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0019143 +name: 3-deoxy-manno-octulosonate-8-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11500] +synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" RELATED [EC:3.1.3.45] +xref: EC:3.1.3.45 +xref: KEGG_REACTION:R03350 +xref: MetaCyc:KDO-8PPHOSPHAT-RXN +xref: RHEA:11500 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019144 +name: ADP-sugar diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] +synonym: "adenosine diphosphosugar pyrophosphatase activity" RELATED [EC:3.6.1.21] +synonym: "ADP-sugar pyrophosphatase activity" RELATED [EC:3.6.1.21] +synonym: "ADP-sugar sugarphosphohydrolase activity" RELATED [EC:3.6.1.21] +synonym: "ADPsugar pyrophosphatase activity" RELATED [EC:3.6.1.21] +synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw] +xref: EC:3.6.1.21 +xref: MetaCyc:ADPSUGPPHOSPHAT-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0019145 +name: aminobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] +synonym: "4-aminobutanal dehydrogenase activity" RELATED [EC:1.2.1.19] +synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.19] +synonym: "4-aminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.19] +synonym: "ABAL dehydrogenase activity" RELATED [EC:1.2.1.19] +synonym: "gamma-aminobutyraldehyde dehydroganase activity" RELATED [EC:1.2.1.19] +xref: EC:1.2.1.19 +xref: MetaCyc:AMINOBUTDEHYDROG-RXN +xref: RHEA:19105 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0019146 +name: arabinose-5-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+)." [EC:5.3.1.13, RHEA:23104] +synonym: "arabinose phosphate isomerase activity" RELATED [EC:5.3.1.13] +synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.13] +synonym: "D-arabinose-5-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.13] +synonym: "phosphoarabinoisomerase activity" RELATED [EC:5.3.1.13] +xref: EC:5.3.1.13 +xref: KEGG_REACTION:R01530 +xref: MetaCyc:DARAB5PISOM-RXN +xref: RHEA:23104 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0019147 +name: (R)-aminopropanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH." [EC:1.1.1.75, RHEA:16517] +synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.75] +synonym: "1-aminopropan-2-ol-dehydrogenase activity" RELATED [EC:1.1.1.75] +synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" RELATED [EC:1.1.1.75] +synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" RELATED [EC:1.1.1.75] +synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" RELATED [EC:1.1.1.75] +synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.75] +synonym: "L-aminopropanol dehydrogenase activity" EXACT [] +xref: EC:1.1.1.75 +xref: KEGG_REACTION:R03759 +xref: MetaCyc:AMINOPROPDEHYDROG-RXN +xref: RHEA:16517 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019148 +name: D-cysteine desulfhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] +synonym: "D-cysteine lyase activity" RELATED [EC:4.4.1.15] +synonym: "D-cysteine sulfide-lyase (deaminating)" RELATED [EC:4.4.1.15] +synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.15] +xref: EC:4.4.1.15 +xref: MetaCyc:DCYSDESULF-RXN +xref: RHEA:11268 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0019149 +name: 3-chloro-D-alanine dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] +synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" RELATED [EC:4.5.1.2] +synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.5.1.2] +synonym: "beta-chloro-D-alanine dehydrochlorinase activity" RELATED [EC:4.5.1.2] +xref: EC:4.5.1.2 +xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN +xref: RHEA:18873 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0019150 +name: D-ribulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] +synonym: "ATP:D-ribulose 5-phosphotransferase activity" RELATED [EC:2.7.1.47] +synonym: "D-ribulokinase (phosphorylating)" RELATED [EC:2.7.1.47] +xref: EC:2.7.1.47 +xref: MetaCyc:D-RIBULOKIN-RXN +xref: RHEA:17601 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0019151 +name: galactose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] +synonym: "beta-galactose dehydrogenase activity" RELATED [EC:1.1.1.48] +synonym: "D-galactose 1-dehydrogenase activity" EXACT [] +synonym: "D-galactose dehydrogenase activity" RELATED [EC:1.1.1.48] +synonym: "D-galactose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.48] +synonym: "NAD-dependent D-galactose dehydrogenase activity" RELATED [EC:1.1.1.48] +xref: EC:1.1.1.48 +xref: MetaCyc:GALACTODEHYDROG-RXN +xref: RHEA:21296 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019152 +name: acetoin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.303, EC:1.1.1.304, MetaCyc:ACETOINDEHYDROG-RXN] +synonym: "diacetyl reductase activity" EXACT [] +xref: EC:1.1.1.303 +xref: EC:1.1.1.304 +xref: KEGG_REACTION:R02343 +xref: MetaCyc:ACETOINDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019153 +name: protein-disulfide reductase (glutathione) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [RHEA:21064] +synonym: "glutaredoxin reductase" RELATED [] +synonym: "glutathione--insulin transhydrogenase activity" RELATED [EC:1.8.4.2] +synonym: "glutathione-insulin transhydrogenase activity" EXACT [] +synonym: "glutathione-protein disulfide oxidoreductase activity" RELATED [EC:1.8.4.2] +synonym: "glutathione:protein-disulfide oxidoreductase activity" RELATED [EC:1.8.4.2] +synonym: "GSH-insulin transhydrogenase activity" RELATED [EC:1.8.4.2] +synonym: "insulin reductase activity" RELATED [EC:1.8.4.2] +synonym: "protein disulfide reductase (glutathione)" RELATED [EC:1.8.4.2] +synonym: "protein disulfide transhydrogenase activity" RELATED [EC:1.8.4.2] +synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] +synonym: "protein-disulfide isomerase/oxidoreductase activity" RELATED [EC:1.8.4.2] +synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] +synonym: "reductase, protein disulfide (glutathione)" RELATED [EC:1.8.4.2] +synonym: "thiol-protein disulphide oxidoreductase activity" RELATED [EC:1.8.4.2] +synonym: "thiol:protein-disulfide oxidoreductase activity" RELATED [EC:1.8.4.2] +xref: EC:1.8.4.2 +xref: MetaCyc:PRODISULFREDUCT-RXN +xref: RHEA:21064 +is_a: GO:0015035 ! protein-disulfide reductase activity +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0019154 +name: glycolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21264] +synonym: "glycolate oxidoreductase activity" RELATED [EC:1.1.99.14] +synonym: "glycolate:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.14] +synonym: "glycolate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.14] +synonym: "glycolic acid dehydrogenase activity" RELATED [EC:1.1.99.14] +xref: EC:1.1.99.14 +xref: KEGG_REACTION:R00476 +xref: MetaCyc:GLYCOLATEDEHYDRO-RXN +xref: RHEA:21264 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0019155 +name: 3-(imidazol-5-yl)lactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] +synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.111] +synonym: "imidazol-5-yl lactate dehydrogenase activity" RELATED [EC:1.1.1.111] +xref: EC:1.1.1.111 +xref: MetaCyc:IMILACTDEHYDROG-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019156 +name: isoamylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] +synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] +synonym: "glycogen alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.68] +xref: EC:3.2.1.68 +xref: MetaCyc:3.2.1.68-RXN +xref: MetaCyc:RXN-12280 +xref: MetaCyc:RXN-14380 +is_a: GO:0004133 ! glycogen debranching enzyme activity +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0019157 +name: obsolete malate oxidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate." [GOC:curators] +comment: This term is slated for obsoletion because RHEA indicates there is not enough experimental evidence. +synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [] +synonym: "FAD-dependent malate oxidase activity" EXACT [] +synonym: "malic dehydrogenase II" RELATED [] +synonym: "malic oxidase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019158 +name: mannokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] +synonym: "ATP:D-mannose 6-phosphotransferase activity" RELATED [EC:2.7.1.7] +synonym: "D-fructose (D-mannose) kinase activity" RELATED [EC:2.7.1.7] +synonym: "mannokinase (phosphorylating)" RELATED [EC:2.7.1.7] +xref: EC:2.7.1.7 +xref: MetaCyc:MANNKIN-RXN +xref: RHEA:11028 +is_a: GO:0004396 ! hexokinase activity + +[Term] +id: GO:0019159 +name: nicotinamide-nucleotide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] +synonym: "nicotinamide mononucleotide amidohydrolase activity" RELATED [EC:3.5.1.42] +synonym: "nicotinamide mononucleotide deamidase activity" RELATED [EC:3.5.1.42] +synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" RELATED [EC:3.5.1.42] +synonym: "NMN amidohydrolase" NARROW [] +synonym: "NMN deamidase activity" RELATED [EC:3.5.1.42] +xref: EC:3.5.1.42 +xref: MetaCyc:NMNAMIDOHYDRO-RXN +xref: RHEA:12400 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019160 +name: NMN nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide." [EC:3.2.2.14, RHEA:23140] +synonym: "nicotinamide mononucleotidase activity" RELATED [EC:3.2.2.14] +synonym: "nicotinamide mononucleotide nucleosidase activity" RELATED [EC:3.2.2.14] +synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" RELATED [EC:3.2.2.14] +synonym: "NMN glycohydrolase activity" RELATED [EC:3.2.2.14] +synonym: "NMNase activity" RELATED [EC:3.2.2.14] +synonym: "NMNGhase activity" RELATED [EC:3.2.2.14] +xref: EC:3.2.2.14 +xref: KEGG_REACTION:R01270 +xref: MetaCyc:NMNNUCLEOSID-RXN +xref: RHEA:23140 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0019161 +name: diamine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] +synonym: "amine transaminase activity" RELATED [EC:2.6.1.29] +synonym: "amine-ketoacid transaminase activity" RELATED [EC:2.6.1.29] +synonym: "diamine aminotransferase activity" EXACT [] +synonym: "diamine-ketoglutaric transaminase activity" RELATED [EC:2.6.1.29] +synonym: "diamine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.29] +xref: EC:2.6.1.29 +xref: MetaCyc:DIAMTRANSAM-RXN +xref: RHEA:18217 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019162 +name: pyridoxamine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10844] +synonym: "pyridoxamine--oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.31] +synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] +synonym: "pyridoxamine:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.31] +xref: EC:2.6.1.31 +xref: KEGG_REACTION:R01713 +xref: MetaCyc:PYROXALTRANSAM-RXN +xref: RHEA:10844 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019163 +name: pyridoxamine-phosphate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] +synonym: "pyridoxamine 5'-phosphate transaminase activity" RELATED [EC:2.6.1.54] +synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.54] +synonym: "pyridoxamine phosphate aminotransferase activity" RELATED [EC:2.6.1.54] +synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" RELATED [EC:2.6.1.54] +synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] +xref: EC:2.6.1.54 +xref: MetaCyc:PYRDAMPTRANS-RXN +xref: RHEA:15877 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019164 +name: pyruvate synthase activity +namespace: molecular_function +alt_id: GO:0018696 +def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG_REACTION:R01196] +synonym: "PFOR" EXACT [] +synonym: "pyruvate oxidoreductase activity" RELATED [EC:1.2.7.1] +synonym: "pyruvate synthetase activity" RELATED [EC:1.2.7.1] +synonym: "pyruvate-ferredoxin reductase activity" EXACT [] +synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.7.1] +synonym: "pyruvate:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.1] +synonym: "pyruvic-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.1] +xref: EC:1.2.7.1 +xref: KEGG_REACTION:R01196 +xref: MetaCyc:PYRUFLAVREDUCT-RXN +xref: RHEA:12765 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0019165 +name: thiamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate." [EC:2.7.1.89, RHEA:12012] +synonym: "ATP:thiamin phosphotransferase activity" RELATED [EC:2.7.1.89] +synonym: "ATP:thiamine phosphotransferase activity" RELATED [EC:2.7.1.89] +synonym: "thiamin kinase (phosphorylating)" RELATED [EC:2.7.1.89] +synonym: "thiamin kinase activity" RELATED [EC:2.7.1.89] +synonym: "thiamin phosphokinase activity" RELATED [EC:2.7.1.89] +xref: EC:2.7.1.89 +xref: KEGG_REACTION:R02134 +xref: MetaCyc:THIKIN-RXN +xref: RHEA:12012 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0019166 +name: trans-2-enoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] +synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" RELATED [EC:1.3.1.38] +synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" RELATED [EC:1.3.1.38] +synonym: "reductase, trans-enoyl coenzyme A" RELATED [EC:1.3.1.38] +xref: EC:1.3.1.38 +xref: MetaCyc:TRANSENOYLCOARED-RXN +xref: Reactome:R-HSA-6786720 "DECR2 reduces LCtE-CoA to t3enoyl-CoA" +xref: Reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA" +xref: Reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA" +xref: RHEA:33763 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019168 +name: 2-octaprenylphenol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] +xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN +xref: RHEA:27790 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0019170 +name: methylglyoxal reductase (NADH-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] +synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.78] +synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] +synonym: "methylglyoxal reductase activity" EXACT [] +xref: EC:1.1.1.78 +xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:24528 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0019171 +name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]." [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN] +synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] +xref: EC:4.2.1.59 +xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN +xref: RHEA:13097 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0019172 +name: glyoxalase III activity +namespace: molecular_function +def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [GOC:mcc, PMID:21696459, PMID:7848303, RHEA:27754] +comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase). +synonym: "(R)-lactate hydro-lyase" EXACT [] +synonym: "D-lactate dehydratase" EXACT [] +synonym: "glutathione-independent glyoxalase activity" RELATED [] +xref: EC:4.2.1.130 +xref: MetaCyc:GLYOXIII-RXN +xref: RHEA:27754 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0019174 +name: tetrahydrothiophene 1-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] +xref: MetaCyc:THTOREDUCT-RXN +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0019176 +name: dihydroneopterin monophosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] +synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] +xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN +xref: RHEA:25306 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0019177 +name: dihydroneopterin triphosphate pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] +xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN +xref: RHEA:25302 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0019178 +name: NADP phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] +xref: MetaCyc:NADPPHOSPHAT-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019179 +name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] +synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] +synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.33] +synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33] +synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33] +synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" RELATED [EC:2.6.1.33] +synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" RELATED [EC:2.6.1.33] +synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.33] +synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" RELATED [EC:2.6.1.33] +xref: EC:2.6.1.33 +xref: MetaCyc:2.6.1.33-RXN +xref: RHEA:19085 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019180 +name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10368] +synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.59] +synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" RELATED [EC:2.6.1.59] +synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] +synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" RELATED [EC:2.6.1.59] +synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" RELATED [EC:2.6.1.59] +xref: EC:2.6.1.59 +xref: KEGG_REACTION:R04438 +xref: MetaCyc:2.6.1.59-RXN +xref: RHEA:10368 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0019181 +name: halohydrin hydrogen-halide-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917] +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0019182 +name: histamine-gated chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0019183 +name: histamine-gated chloride channel complex +namespace: cellular_component +def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] +is_a: GO:0034707 ! chloride channel complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0019184 +name: nonribosomal peptide biosynthetic process +namespace: biological_process +def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732] +synonym: "non-ribosomal peptide biosynthesis" EXACT [] +synonym: "non-ribosomal peptide biosynthetic process" EXACT [] +synonym: "non-ribosomal peptide formation" EXACT [] +synonym: "non-ribosomal peptide synthesis" EXACT [] +synonym: "nonribosomal peptide anabolism" EXACT [] +synonym: "nonribosomal peptide biosynthesis" EXACT [] +synonym: "nonribosomal peptide formation" EXACT [] +synonym: "nonribosomal peptide synthesis" EXACT [] +synonym: "nonribosomal peptide synthetase" RELATED [] +is_a: GO:0043043 ! peptide biosynthetic process + +[Term] +id: GO:0019185 +name: snRNA-activating protein complex +namespace: cellular_component +def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] +synonym: "SNAPc" EXACT [] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0019186 +name: acyl-CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0019187 +name: beta-1,4-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646] +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0019191 +name: cellobiose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019190 +def: "Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "cellobiose permease activity" EXACT [] +is_a: GO:0015154 ! disaccharide transmembrane transporter activity + +[Term] +id: GO:0019194 +name: sorbose transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019193 +def: "Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "sorbose porter activity" EXACT [] +is_a: GO:0015149 ! hexose transmembrane transporter activity + +[Term] +id: GO:0019196 +name: galactosamine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0019195 +def: "Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +synonym: "galactosamine porter activity" EXACT [] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0019197 +name: phosphoenolpyruvate-dependent sugar phosphotransferase complex +namespace: cellular_component +def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0019198 +name: transmembrane receptor protein phosphatase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd] +is_a: GO:0004721 ! phosphoprotein phosphatase activity +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0019199 +name: transmembrane receptor protein kinase activity +namespace: molecular_function +def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] +xref: Reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex" +xref: Reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated" +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0019200 +name: carbohydrate kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] +xref: Reactome:R-HSA-8931653 "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1" +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019202 +name: amino acid kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019203 +name: carbohydrate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] +xref: Reactome:R-HSA-3781011 "EPM2A dimer dephosphorylates phosphoglycogen-GYG2" +xref: Reactome:R-HSA-3781018 "EPM2A dimer dephosphorylates phosphoglycogen-GYG1" +xref: Reactome:R-HSA-3791349 "Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)" +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0019204 +name: obsolete nucleotide phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] +comment: This term was defined to cover phosphatase activity against polynucleotides, but had subclasses and annotations for phosphatase activity against free nucleotides. It has therefore been split. Use GO:0098519 (nucleotide phosphatase activity, acting against free nucleotides) or GO:0098518 (polynucleotide phosphatase activity). +synonym: "nucleotide phosphatase activity" EXACT [] +is_obsolete: true +consider: GO:0098518 +consider: GO:0098519 + +[Term] +id: GO:0019205 +name: nucleobase-containing compound kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] +synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0019206 +name: nucleoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] +xref: Reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)" +xref: Reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]" +xref: Reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]" +xref: Reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP" +xref: Reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs" +xref: Reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)" +xref: Reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]" +xref: Reactome:R-HSA-73632 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]" +xref: Reactome:R-HSA-74207 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)" +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0019207 +name: kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0019208 +name: phosphatase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0019209 +name: kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019210 +name: kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a kinase." [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019211 +name: phosphatase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0019208 ! phosphatase regulator activity + +[Term] +id: GO:0019212 +name: phosphatase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0019208 ! phosphatase regulator activity + +[Term] +id: GO:0019213 +name: deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] +subset: goslim_pir +xref: Reactome:R-HSA-5689000 "AADAC deacetylates PHEN" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0019214 +name: obsolete surfactant activity +namespace: molecular_function +def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it represents involvement in a process. +synonym: "surfactant activity" EXACT [] +is_obsolete: true +consider: GO:0050828 + +[Term] +id: GO:0019215 +name: intermediate filament binding +namespace: molecular_function +def: "Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0019216 +name: regulation of lipid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +synonym: "regulation of lipid metabolism" EXACT [] +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0019217 +name: regulation of fatty acid metabolic process +namespace: biological_process +alt_id: GO:0006632 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +synonym: "regulation of fatty acid metabolism" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0019218 +name: regulation of steroid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +synonym: "regulation of steroid metabolism" EXACT [] +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0019219 +name: regulation of nucleobase-containing compound metabolic process +namespace: biological_process +def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process + +[Term] +id: GO:0019220 +name: regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +synonym: "regulation of phosphate metabolism" EXACT [] +is_a: GO:0051174 ! regulation of phosphorus metabolic process +relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process + +[Term] +id: GO:0019221 +name: cytokine-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] +synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] +synonym: "cytokine mediated signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway +relationship: part_of GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0019222 +name: regulation of metabolic process +namespace: biological_process +alt_id: GO:0044246 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] +subset: goslim_metagenomics +synonym: "regulation of metabolism" EXACT [] +synonym: "regulation of multicellular organismal metabolic process" NARROW [] +synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0019226 +name: transmission of nerve impulse +namespace: biological_process +def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] +synonym: "conduction of nerve impulse" EXACT [GOC:dph] +synonym: "signal transmission along a neuron" EXACT [] +is_a: GO:0035637 ! multicellular organismal signaling +is_a: GO:0050877 ! nervous system process +relationship: part_of GO:0007154 ! cell communication + +[Term] +id: GO:0019227 +name: neuronal action potential propagation +namespace: biological_process +def: "The propagation of an action potential along an axon, away from the soma." [GOC:isa_complete] +is_a: GO:0050877 ! nervous system process +is_a: GO:0098870 ! action potential propagation +relationship: part_of GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0019228 +name: neuronal action potential +namespace: biological_process +def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001508 ! action potential +relationship: part_of GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0019229 +name: regulation of vasoconstriction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] +is_a: GO:0097746 ! blood vessel diameter maintenance +is_a: GO:1903522 ! regulation of blood circulation +relationship: regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0019230 +name: proprioception +namespace: biological_process +def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [ISBN:072168677X] +xref: Wikipedia:Proprioception +is_a: GO:0007600 ! sensory perception +relationship: part_of GO:0050884 ! neuromuscular process controlling posture + +[Term] +id: GO:0019231 +name: perception of static position +namespace: biological_process +def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X] +is_a: GO:0019230 ! proprioception + +[Term] +id: GO:0019232 +name: perception of rate of movement +namespace: biological_process +def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah] +synonym: "kinesthesia" EXACT [] +is_a: GO:0019230 ! proprioception + +[Term] +id: GO:0019233 +name: sensory perception of pain +namespace: biological_process +def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [GOC:curators] +synonym: "nociception" EXACT [] +synonym: "perception of physiological pain" NARROW [] +xref: Wikipedia:Nociception +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0019234 +name: sensory perception of fast pain +namespace: biological_process +def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/] +is_a: GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0019235 +name: sensory perception of slow pain +namespace: biological_process +def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/] +is_a: GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0019236 +name: response to pheromone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] +synonym: "pheromone response" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0019237 +name: centromeric DNA binding +namespace: molecular_function +def: "Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577] +synonym: "centromere binding" EXACT [] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0019238 +name: cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah] +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0019239 +name: deaminase activity +namespace: molecular_function +def: "Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R)." [GOC:jl] +subset: goslim_pir +xref: Reactome:R-HSA-9014641 "HRSP12 deaminates 2AA to 2OBUTA" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0019240 +name: citrulline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] +synonym: "citrulline anabolism" EXACT [] +synonym: "citrulline biosynthesis" EXACT [] +synonym: "citrulline formation" EXACT [] +synonym: "citrulline synthesis" EXACT [] +xref: MetaCyc:CITRULBIO-PWY +is_a: GO:0000052 ! citrulline metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0019241 +name: citrulline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] +synonym: "citrulline breakdown" EXACT [] +synonym: "citrulline catabolism" EXACT [] +synonym: "citrulline degradation" EXACT [] +xref: MetaCyc:CITRULLINE-DEG-PWY +is_a: GO:0000052 ! citrulline metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0019242 +name: methylglyoxal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] +synonym: "methylglyoxal anabolism" EXACT [] +synonym: "methylglyoxal biosynthesis" EXACT [] +synonym: "methylglyoxal formation" EXACT [] +synonym: "methylglyoxal synthesis" EXACT [] +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process + +[Term] +id: GO:0019243 +name: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020] +synonym: "D-lactate biosynthesis from methylglyoxal" BROAD [] +synonym: "D-lactate biosynthetic process from methylglyoxal" BROAD [] +synonym: "glyoxalase system" RELATED [] +synonym: "methylglyoxal breakdown to D-lactate" BROAD [] +synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT [] +synonym: "methylglyoxal degradation to D-lactate" BROAD [] +synonym: "methylglyoxal detoxification" RELATED [] +xref: MetaCyc:PWY-5386 +is_a: GO:0061727 ! methylglyoxal catabolic process to lactate + +[Term] +id: GO:0019244 +name: lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators] +synonym: "lactate anabolism from pyruvate" EXACT [] +synonym: "lactate formation from pyruvate" EXACT [] +synonym: "lactate synthesis from pyruvate" EXACT [] +synonym: "pyruvate fermentation to lactate" EXACT [] +xref: Reactome:R-HSA-71849.1 +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0019249 ! lactate biosynthetic process + +[Term] +id: GO:0019245 +name: D(-)-lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators] +synonym: "D(-)-lactate anabolism from pyruvate" EXACT [] +synonym: "D(-)-lactate formation from pyruvate" EXACT [] +synonym: "D(-)-lactate synthesis from pyruvate" EXACT [] +is_a: GO:0019244 ! lactate biosynthetic process from pyruvate + +[Term] +id: GO:0019246 +name: L(+)-lactate biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate." [GOC:go_curators] +synonym: "L(+)-lactate anabolism from pyruvate" EXACT [] +synonym: "L(+)-lactate formation from pyruvate" EXACT [] +synonym: "L(+)-lactate synthesis from pyruvate" EXACT [] +synonym: "S-lactate biosynthetic process from pyruvate" EXACT [] +xref: MetaCyc:PWY-5481 +is_a: GO:0019244 ! lactate biosynthetic process from pyruvate + +[Term] +id: GO:0019247 +name: lactate racemization +namespace: biological_process +def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538] +is_a: GO:0006089 ! lactate metabolic process + +[Term] +id: GO:0019248 +name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY] +synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT [] +synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT [] +synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT [] +xref: MetaCyc:MGLDLCTANA-PWY +is_a: GO:0019249 ! lactate biosynthetic process +is_a: GO:0061727 ! methylglyoxal catabolic process to lactate + +[Term] +id: GO:0019249 +name: lactate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] +synonym: "lactate anabolism" EXACT [] +synonym: "lactate biosynthesis" EXACT [] +synonym: "lactate formation" EXACT [] +synonym: "lactate synthesis" EXACT [] +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0019250 +name: aerobic cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators] +synonym: "aerobic cobalamin anabolism" EXACT [] +synonym: "aerobic cobalamin biosynthesis" EXACT [] +synonym: "aerobic cobalamin formation" EXACT [] +synonym: "aerobic cobalamin synthesis" EXACT [] +synonym: "aerobic vitamin B12 biosynthesis" EXACT [] +synonym: "aerobic vitamin B12 biosynthetic process" EXACT [] +synonym: "cobalamin biosynthesis, aerobic" EXACT [] +synonym: "cobalamin biosynthetic process, aerobic" EXACT [] +synonym: "vitamin B12 biosynthesis, aerobic" EXACT [] +synonym: "vitamin B12 biosynthetic process, aerobic" EXACT [] +xref: MetaCyc:P381-PWY +is_a: GO:0009236 ! cobalamin biosynthetic process + +[Term] +id: GO:0019251 +name: anaerobic cobalamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators] +synonym: "anaerobic cobalamin anabolism" EXACT [] +synonym: "anaerobic cobalamin biosynthesis" EXACT [] +synonym: "anaerobic cobalamin formation" EXACT [] +synonym: "anaerobic cobalamin synthesis" EXACT [] +synonym: "anaerobic vitamin B12 biosynthesis" EXACT [] +synonym: "anaerobic vitamin B12 biosynthetic process" EXACT [] +synonym: "cobalamin biosynthesis, anaerobic" EXACT [] +synonym: "cobalamin biosynthetic process, anaerobic" EXACT [] +synonym: "vitamin B12 biosynthesis, anaerobic" EXACT [] +synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT [] +xref: MetaCyc:COBALSYN-PWY +is_a: GO:0009236 ! cobalamin biosynthetic process + +[Term] +id: GO:0019252 +name: starch biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] +synonym: "starch anabolism" EXACT [] +synonym: "starch biosynthesis" EXACT [] +synonym: "starch formation" EXACT [] +synonym: "starch synthesis" EXACT [] +xref: MetaCyc:PWY-622 +is_a: GO:0005982 ! starch metabolic process +is_a: GO:0009250 ! glucan biosynthetic process + +[Term] +id: GO:0019253 +name: reductive pentose-phosphate cycle +namespace: biological_process +def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684] +comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. +synonym: "C3 photosynthesis" NARROW [] +synonym: "Calvin cycle" NARROW [] +xref: MetaCyc:CALVIN-PWY +is_a: GO:0019685 ! photosynthesis, dark reaction +relationship: part_of GO:0015977 ! carbon fixation + +[Term] +id: GO:0019254 +name: carnitine metabolic process, CoA-linked +namespace: biological_process +def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] +synonym: "carnitine metabolism, CoA-linked" EXACT [] +xref: MetaCyc:CARNMET-PWY +is_a: GO:0009437 ! carnitine metabolic process + +[Term] +id: GO:0019255 +name: glucose 1-phosphate metabolic process +namespace: biological_process +alt_id: GO:0006008 +def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] +synonym: "glucose 1-phosphate metabolism" EXACT [] +synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah] +xref: MetaCyc:GLUCOSE1PMETAB-PWY +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0019256 +name: acrylonitrile catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai] +synonym: "acrylonitrile breakdown" EXACT [] +synonym: "acrylonitrile catabolism" EXACT [] +synonym: "acrylonitrile degradation" EXACT [] +xref: MetaCyc:P344-PWY +is_a: GO:0018865 ! acrylonitrile metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0050899 ! nitrile catabolic process + +[Term] +id: GO:0019257 +name: 4-nitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai] +synonym: "4-nitrotoluene metabolism" EXACT [] +synonym: "4NT metabolic process" EXACT [] +synonym: "4NT metabolism" EXACT [] +is_a: GO:0019326 ! nitrotoluene metabolic process + +[Term] +id: GO:0019258 +name: 4-nitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] +synonym: "4-nitrotoluene breakdown" EXACT [] +synonym: "4-nitrotoluene catabolism" EXACT [] +synonym: "4-nitrotoluene degradation" EXACT [] +synonym: "4NT catabolic process" EXACT [] +synonym: "4NT catabolism" EXACT [] +xref: MetaCyc:P421-PWY +is_a: GO:0019257 ! 4-nitrotoluene metabolic process +is_a: GO:0046263 ! nitrotoluene catabolic process + +[Term] +id: GO:0019260 +name: 1,2-dichloroethane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators] +synonym: "1,2-dichloroethane breakdown" EXACT [] +synonym: "1,2-dichloroethane catabolism" EXACT [] +synonym: "1,2-dichloroethane degradation" EXACT [] +xref: MetaCyc:12DICHLORETHDEG-PWY +is_a: GO:0018899 ! 1,2-dichloroethane metabolic process +is_a: GO:0042206 ! halogenated hydrocarbon catabolic process + +[Term] +id: GO:0019261 +name: 1,4-dichlorobenzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai] +synonym: "1,4-dichlorobenzene breakdown" EXACT [] +synonym: "1,4-dichlorobenzene catabolism" EXACT [] +synonym: "1,4-dichlorobenzene degradation" EXACT [] +xref: MetaCyc:14DICHLORBENZDEG-PWY +is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019262 +name: N-acetylneuraminate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] +synonym: "N-acetylneuraminate breakdown" EXACT [] +synonym: "N-acetylneuraminate catabolism" EXACT [] +synonym: "N-acetylneuraminate degradation" EXACT [] +xref: MetaCyc:P441-PWY +is_a: GO:0006054 ! N-acetylneuraminate metabolic process +is_a: GO:0046348 ! amino sugar catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0019263 +name: adamantanone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] +synonym: "adamantanone breakdown" EXACT [] +synonym: "adamantanone catabolism" EXACT [] +synonym: "adamantanone degradation" EXACT [] +xref: MetaCyc:P481-PWY +is_a: GO:0018866 ! adamantanone metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019264 +name: glycine biosynthetic process from serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators] +synonym: "glycine anabolism from serine" EXACT [] +synonym: "glycine formation from serine" EXACT [] +synonym: "glycine synthesis from serine" EXACT [] +xref: MetaCyc:GLYSYN-PWY +is_a: GO:0006545 ! glycine biosynthetic process +is_a: GO:0006563 ! L-serine metabolic process + +[Term] +id: GO:0019265 +name: glycine biosynthetic process, by transamination of glyoxylate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators] +synonym: "glycine anabolism, by transamination of glyoxylate" EXACT [] +synonym: "glycine formation, by transamination of glyoxylate" EXACT [] +synonym: "glycine synthesis, by transamination of glyoxylate" EXACT [] +is_a: GO:0006545 ! glycine biosynthetic process + +[Term] +id: GO:0019266 +name: asparagine biosynthetic process from oxaloacetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators] +synonym: "asparagine anabolism from oxaloacetate" EXACT [] +synonym: "asparagine formation from oxaloacetate" EXACT [] +synonym: "asparagine synthesis from oxaloacetate" EXACT [] +xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS +is_a: GO:0006107 ! oxaloacetate metabolic process +is_a: GO:0006529 ! asparagine biosynthetic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0019267 +name: asparagine biosynthetic process from cysteine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators] +synonym: "asparagine anabolism from cysteine" EXACT [] +synonym: "asparagine formation from cysteine" EXACT [] +synonym: "asparagine synthesis from cysteine" EXACT [] +xref: MetaCyc:ASPSYNII-PWY +is_a: GO:0006529 ! asparagine biosynthetic process +is_a: GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:0019268 +name: obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators] +comment: This term was made obsolete because it represents a molecular function. +synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT [] +is_obsolete: true +consider: GO:0004353 +consider: GO:0006537 + +[Term] +id: GO:0019269 +name: obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators] +comment: This term was made obsolete because it refers to a molecular function. +synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT [] +is_obsolete: true +consider: GO:0004355 +consider: GO:0006537 + +[Term] +id: GO:0019270 +name: aerobactin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] +synonym: "aerobactin anabolism" EXACT [] +synonym: "aerobactin biosynthesis" EXACT [] +synonym: "aerobactin formation" EXACT [] +synonym: "aerobactin synthesis" EXACT [] +xref: MetaCyc:AEROBACTINSYN-PWY +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0046442 ! aerobactin metabolic process +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process + +[Term] +id: GO:0019271 +name: aerobactin transport +namespace: biological_process +def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658] +is_a: GO:0006842 ! tricarboxylic acid transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0019272 +name: L-alanine biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators] +synonym: "L-alanine anabolism from pyruvate" EXACT [] +synonym: "L-alanine formation from pyruvate" EXACT [] +synonym: "L-alanine synthesis from pyruvate" EXACT [] +xref: MetaCyc:ALANINE-SYN2-PWY +xref: MetaCyc:ALANINE-VALINESYN-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0042852 ! L-alanine biosynthetic process + +[Term] +id: GO:0019273 +name: L-alanine biosynthetic process via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators] +synonym: "L-alanine anabolism via ornithine" EXACT [] +synonym: "L-alanine formation via ornithine" EXACT [] +synonym: "L-alanine synthesis via ornithine" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0042852 ! L-alanine biosynthetic process + +[Term] +id: GO:0019276 +name: UDP-N-acetylgalactosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylgalactosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0019277 +name: UDP-N-acetylgalactosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylgalactosamine anabolism" EXACT [] +synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT [] +synonym: "UDP-N-acetylgalactosamine formation" EXACT [] +synonym: "UDP-N-acetylgalactosamine synthesis" EXACT [] +xref: MetaCyc:UDPNACETYLGALSYN-PWY +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0019278 +name: UDP-N-acetylgalactosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-N-acetylgalactosamine breakdown" EXACT [] +synonym: "UDP-N-acetylgalactosamine catabolism" EXACT [] +synonym: "UDP-N-acetylgalactosamine degradation" EXACT [] +is_a: GO:0009227 ! nucleotide-sugar catabolic process +is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0019279 +name: L-methionine biosynthetic process from L-homoserine via cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators] +synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah] +synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah] +xref: MetaCyc:HOMOSER-METSYN-PWY +is_a: GO:0009092 ! homoserine metabolic process +is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process + +[Term] +id: GO:0019280 +name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators] +synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] +xref: MetaCyc:HSERMETANA-PWY +is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0019281 +name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators] +synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] +xref: MetaCyc:MET-SAM-PWY +is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0019283 +name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators] +synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process + +[Term] +id: GO:0019284 +name: L-methionine salvage from S-adenosylmethionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine." [GOC:go_curators, GOC:vw] +synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah] +is_a: GO:0071267 ! L-methionine salvage +relationship: part_of GO:0033353 ! S-adenosylmethionine cycle + +[Term] +id: GO:0019285 +name: glycine betaine biosynthetic process from choline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl] +synonym: "choline oxidation" EXACT [GOC:dph, PMID:23563483] +synonym: "glycine betaine anabolism from choline" EXACT [] +synonym: "glycine betaine formation from choline" EXACT [] +synonym: "glycine betaine synthesis from choline" EXACT [] +synonym: "N-trimethylglycine biosynthesis from choline" EXACT [] +synonym: "N-trimethylglycine biosynthetic process from choline" EXACT [] +xref: MetaCyc:BETSYN-PWY +xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY +xref: MetaCyc:P542-PWY +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0031456 ! glycine betaine biosynthetic process + +[Term] +id: GO:0019286 +name: glycine betaine biosynthetic process from glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators] +synonym: "glycine betaine anabolism from glycine" EXACT [] +synonym: "glycine betaine formation from glycine" EXACT [] +synonym: "glycine betaine synthesis from glycine" EXACT [] +synonym: "N-trimethylglycine biosynthesis from glycine" EXACT [] +synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT [] +xref: MetaCyc:P541-PWY +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0031456 ! glycine betaine biosynthetic process + +[Term] +id: GO:0019287 +name: isopentenyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922] +synonym: "Ac-MVA pathway" EXACT [PMID:14517367] +synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367] +synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr] +synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process + +[Term] +id: GO:0019288 +name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055] +synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT [] +synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:pr] +synonym: "isopentenyl diphosphate biosynthetic process, MEP pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] +synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT [] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT [] +synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT [] +synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT [] +synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT [] +synonym: "non-MVA pathway" EXACT [] +xref: MetaCyc:NONMEVIPP-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process + +[Term] +id: GO:0019289 +name: rhizobactin 1021 biosynthetic process +namespace: biological_process +alt_id: GO:0031193 +alt_id: GO:0031194 +def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] +synonym: "rhizobactin 1021 anabolism" EXACT [] +synonym: "rhizobactin 1021 biosynthesis" EXACT [] +synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW [] +synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW [] +synonym: "rhizobactin 1021 formation" EXACT [] +synonym: "rhizobactin 1021 synthesis" EXACT [] +xref: MetaCyc:PWY-761 +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019540 ! catechol-containing siderophore biosynthetic process +is_a: GO:0046494 ! rhizobactin 1021 metabolic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:0019290 +name: siderophore biosynthetic process +namespace: biological_process +alt_id: GO:0031178 +alt_id: GO:0031180 +def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [PMID:20376388] +synonym: "siderochrome biosynthesis" NARROW [] +synonym: "siderochrome biosynthetic process" NARROW [] +synonym: "siderophore anabolism" EXACT [] +synonym: "siderophore biosynthesis" EXACT [] +synonym: "siderophore biosynthetic process, peptide formation" NARROW [] +synonym: "siderophore biosynthetic process, peptide modification" NARROW [] +synonym: "siderophore formation" EXACT [] +synonym: "siderophore synthesis" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0019184 ! nonribosomal peptide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0019292 +name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators] +synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT [] +xref: MetaCyc:TYRSYN +is_a: GO:0006571 ! tyrosine biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0019293 +name: tyrosine biosynthetic process, by oxidation of phenylalanine +namespace: biological_process +alt_id: GO:0019291 +def: "The conversion of phenylalanine to tyrosine." [PMID:4004813] +synonym: "L-tyrosine biosynthesis IV" EXACT [] +synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT [] +synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT [] +synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT [] +xref: MetaCyc:PWY-6134 +is_a: GO:0006571 ! tyrosine biosynthetic process + +[Term] +id: GO:0019294 +name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [ISBN:0198506732] +synonym: "KDO biosynthesis" EXACT [] +synonym: "KDO biosynthetic process" EXACT [] +synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] +synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] +synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] +synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] +synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] +xref: MetaCyc:KDOSYN-PWY +is_a: GO:0046364 ! monosaccharide biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process +relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process + +[Term] +id: GO:0019295 +name: coenzyme M biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684] +synonym: "coenzyme M anabolism" EXACT [] +synonym: "coenzyme M biosynthesis" EXACT [] +synonym: "coenzyme M formation" EXACT [] +synonym: "coenzyme M synthesis" EXACT [] +xref: MetaCyc:P261-PWY +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019296 ! coenzyme M metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0019296 +name: coenzyme M metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] +synonym: "coenzyme M metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019297 +name: coenzyme B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] +synonym: "coenzyme B metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019298 +name: coenzyme B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051] +synonym: "coenzyme B anabolism" EXACT [] +synonym: "coenzyme B biosynthesis" EXACT [] +synonym: "coenzyme B formation" EXACT [] +synonym: "coenzyme B synthesis" EXACT [] +xref: MetaCyc:P241-PWY +is_a: GO:0019297 ! coenzyme B metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0019299 +name: rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732] +synonym: "rhamnose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019300 +name: rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] +synonym: "rhamnose anabolism" EXACT [] +synonym: "rhamnose biosynthesis" EXACT [] +synonym: "rhamnose formation" EXACT [] +synonym: "rhamnose synthesis" EXACT [] +is_a: GO:0019299 ! rhamnose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0019301 +name: rhamnose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] +synonym: "rhamnose breakdown" EXACT [] +synonym: "rhamnose catabolism" EXACT [] +synonym: "rhamnose degradation" EXACT [] +xref: MetaCyc:RHAMCAT-PWY +is_a: GO:0019299 ! rhamnose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019302 +name: D-ribose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732] +synonym: "D-ribose anabolism" EXACT [] +synonym: "D-ribose biosynthesis" EXACT [] +synonym: "D-ribose formation" EXACT [] +synonym: "D-ribose synthesis" EXACT [] +is_a: GO:0006014 ! D-ribose metabolic process +is_a: GO:0019322 ! pentose biosynthetic process + +[Term] +id: GO:0019303 +name: D-ribose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732] +synonym: "D-ribose breakdown" EXACT [] +synonym: "D-ribose catabolism" EXACT [] +synonym: "D-ribose degradation" EXACT [] +xref: MetaCyc:RIBOKIN-PWY +is_a: GO:0006014 ! D-ribose metabolic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:0019304 +name: anaerobic rhamnose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai] +synonym: "anaerobic rhamnose breakdown" EXACT [] +synonym: "anaerobic rhamnose catabolism" EXACT [] +synonym: "anaerobic rhamnose degradation" EXACT [] +is_a: GO:0019301 ! rhamnose catabolic process + +[Term] +id: GO:0019305 +name: dTDP-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +synonym: "dTDP-rhamnose anabolism" EXACT [] +synonym: "dTDP-rhamnose biosynthesis" EXACT [] +synonym: "dTDP-rhamnose formation" EXACT [] +synonym: "dTDP-rhamnose synthesis" EXACT [] +xref: MetaCyc:DTDPRHAMSYN-PWY +xref: MetaCyc:PWY-3221 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046383 ! dTDP-rhamnose metabolic process + +[Term] +id: GO:0019306 +name: GDP-D-rhamnose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-D-rhamnose anabolism" EXACT [] +synonym: "GDP-D-rhamnose biosynthesis" EXACT [] +synonym: "GDP-D-rhamnose formation" EXACT [] +synonym: "GDP-D-rhamnose synthesis" EXACT [] +xref: MetaCyc:GDPRHAMSYN-PWY +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046382 ! GDP-D-rhamnose metabolic process + +[Term] +id: GO:0019307 +name: mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] +synonym: "mannose anabolism" EXACT [] +synonym: "mannose biosynthesis" EXACT [] +synonym: "mannose formation" EXACT [] +synonym: "mannose synthesis" EXACT [] +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0019308 +name: dTDP-mannose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +synonym: "dTDP-mannose anabolism" EXACT [] +synonym: "dTDP-mannose biosynthesis" EXACT [] +synonym: "dTDP-mannose formation" EXACT [] +synonym: "dTDP-mannose synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046371 ! dTDP-mannose metabolic process + +[Term] +id: GO:0019309 +name: mannose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] +synonym: "mannose breakdown" EXACT [] +synonym: "mannose catabolism" EXACT [] +synonym: "mannose degradation" EXACT [] +xref: MetaCyc:MANNCAT-PWY +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019310 +name: inositol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:go_curators] +synonym: "inositol breakdown" EXACT [] +synonym: "inositol catabolism" EXACT [] +synonym: "inositol degradation" EXACT [] +synonym: "myo-inositol catabolic process" NARROW [] +synonym: "myo-inositol catabolism" NARROW [] +synonym: "vitamin Bh catabolic process" EXACT [] +synonym: "vitamin Bh catabolism" EXACT [] +xref: MetaCyc:P562-PWY +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0019311 +name: sorbose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] +synonym: "sorbose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019312 +name: L-sorbose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-sorbose metabolism" EXACT [] +xref: MetaCyc:P302-PWY +is_a: GO:0019311 ! sorbose metabolic process + +[Term] +id: GO:0019313 +name: allose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] +synonym: "allose metabolism" EXACT [] +is_a: GO:0019318 ! hexose metabolic process + +[Term] +id: GO:0019314 +name: D-allose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-allose metabolism" EXACT [] +is_a: GO:0019313 ! allose metabolic process + +[Term] +id: GO:0019315 +name: D-allose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-allose anabolism" EXACT [] +synonym: "D-allose biosynthesis" EXACT [] +synonym: "D-allose formation" EXACT [] +synonym: "D-allose synthesis" EXACT [] +is_a: GO:0019314 ! D-allose metabolic process +is_a: GO:0046366 ! allose biosynthetic process + +[Term] +id: GO:0019316 +name: D-allose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-allose breakdown" EXACT [] +synonym: "D-allose catabolism" EXACT [] +synonym: "D-allose degradation" EXACT [] +xref: MetaCyc:PWY0-44 +is_a: GO:0019314 ! D-allose metabolic process +is_a: GO:0046367 ! allose catabolic process + +[Term] +id: GO:0019317 +name: fucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl] +synonym: "fucose breakdown" EXACT [] +synonym: "fucose catabolism" EXACT [] +synonym: "fucose degradation" EXACT [] +xref: MetaCyc:FUCCAT-PWY +is_a: GO:0006004 ! fucose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019318 +name: hexose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0019319 +name: hexose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexose anabolism" EXACT [] +synonym: "hexose biosynthesis" EXACT [] +synonym: "hexose formation" EXACT [] +synonym: "hexose synthesis" EXACT [] +is_a: GO:0019318 ! hexose metabolic process +is_a: GO:0046364 ! monosaccharide biosynthetic process + +[Term] +id: GO:0019320 +name: hexose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexose breakdown" EXACT [] +synonym: "hexose catabolism" EXACT [] +synonym: "hexose degradation" EXACT [] +is_a: GO:0019318 ! hexose metabolic process +is_a: GO:0046365 ! monosaccharide catabolic process + +[Term] +id: GO:0019321 +name: pentose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0019322 +name: pentose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentose anabolism" EXACT [] +synonym: "pentose biosynthesis" EXACT [] +synonym: "pentose formation" EXACT [] +synonym: "pentose synthesis" EXACT [] +is_a: GO:0019321 ! pentose metabolic process +is_a: GO:0046364 ! monosaccharide biosynthetic process + +[Term] +id: GO:0019323 +name: pentose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentose breakdown" EXACT [] +synonym: "pentose catabolism" EXACT [] +synonym: "pentose degradation" EXACT [] +is_a: GO:0019321 ! pentose metabolic process +is_a: GO:0046365 ! monosaccharide catabolic process + +[Term] +id: GO:0019324 +name: L-lyxose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-lyxose metabolism" EXACT [] +xref: MetaCyc:LYXMET-PWY +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0019325 +name: anaerobic fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai] +synonym: "anaerobic fructose breakdown" EXACT [] +synonym: "anaerobic fructose catabolism" EXACT [] +synonym: "anaerobic fructose degradation" EXACT [] +xref: MetaCyc:ANAEROFRUCAT-PWY +is_a: GO:0006001 ! fructose catabolic process +is_a: GO:0019317 ! fucose catabolic process + +[Term] +id: GO:0019326 +name: nitrotoluene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +synonym: "nitrotoluene metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process + +[Term] +id: GO:0019327 +name: lead sulfide oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY] +synonym: "lead sulphide oxidation" EXACT [GOC:mah] +synonym: "oxidation of galena" EXACT [] +synonym: "oxidation of lead sulfide" EXACT [] +xref: MetaCyc:P301-PWY +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019328 +name: anaerobic gallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl] +synonym: "anaerobic gallate breakdown" EXACT [] +synonym: "anaerobic gallate catabolism" EXACT [] +synonym: "anaerobic gallate degradation" EXACT [] +synonym: "anaerobic gallic acid catabolic process" EXACT [] +synonym: "anaerobic gallic acid catabolism" EXACT [] +synonym: "gallate fermentation" EXACT [] +xref: MetaCyc:P3-PWY +is_a: GO:0019396 ! gallate catabolic process + +[Term] +id: GO:0019329 +name: ammonia oxidation +namespace: biological_process +def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0019330 +name: aldoxime metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [GOC:curators] +synonym: "aldoxime metabolism" EXACT [] +xref: MetaCyc:P345-PWY +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0019331 +name: anaerobic respiration, using ammonium as electron donor +namespace: biological_process +def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY] +synonym: "anaerobic ammonium oxidation" BROAD [] +synonym: "anammox" EXACT [] +xref: MetaCyc:P303-PWY +xref: Wikipedia:Anammox +is_a: GO:0009061 ! anaerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0019329 ! ammonia oxidation +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0019332 +name: aerobic respiration, using nitrite as electron donor +namespace: biological_process +def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY] +synonym: "nitrite oxidation" BROAD [] +xref: MetaCyc:P282-PWY +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0019333 +name: denitrification pathway +namespace: biological_process +def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY] +xref: MetaCyc:DENITRIFICATION-PWY +is_a: GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:0019334 +name: p-cymene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai] +synonym: "p-cymene breakdown" EXACT [] +synonym: "p-cymene catabolism" EXACT [] +synonym: "p-cymene degradation" EXACT [] +xref: MetaCyc:PWY-741 +is_a: GO:0018953 ! p-cymene metabolic process +is_a: GO:0043694 ! monoterpene catabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process + +[Term] +id: GO:0019335 +name: 3-methylquinoline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] +synonym: "3-methylquinoline breakdown" EXACT [] +synonym: "3-methylquinoline catabolism" EXACT [] +synonym: "3-methylquinoline degradation" EXACT [] +xref: MetaCyc:PWY-721 +is_a: GO:0018930 ! 3-methylquinoline metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0019336 +name: phenol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [ISBN:0198506732] +synonym: "phenol-containing compound breakdown" EXACT [] +synonym: "phenol-containing compound catabolism" EXACT [] +synonym: "phenol-containing compound degradation" EXACT [] +xref: MetaCyc:PHENOLDEG-PWY +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0019337 +name: tetrachloroethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai] +synonym: "tetrachloroethene catabolic process" EXACT [] +synonym: "tetrachloroethene catabolism" EXACT [] +synonym: "tetrachloroethylene breakdown" EXACT [] +synonym: "tetrachloroethylene catabolism" EXACT [] +synonym: "tetrachloroethylene degradation" EXACT [] +xref: MetaCyc:PCEDEG-PWY +is_a: GO:0018967 ! tetrachloroethylene metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0019338 +name: pentachlorophenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators] +synonym: "pentachlorophenol breakdown" EXACT [] +synonym: "pentachlorophenol catabolism" EXACT [] +synonym: "pentachlorophenol degradation" EXACT [] +xref: MetaCyc:PCPDEG-PWY +is_a: GO:0018961 ! pentachlorophenol metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process + +[Term] +id: GO:0019339 +name: parathion catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] +synonym: "parathion breakdown" EXACT [] +synonym: "parathion catabolism" EXACT [] +synonym: "parathion degradation" EXACT [] +xref: MetaCyc:PARATHION-DEGRADATION-PWY +is_a: GO:0018952 ! parathion metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0019340 +name: dibenzofuran catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai] +synonym: "dibenzofuran breakdown" EXACT [] +synonym: "dibenzofuran catabolism" EXACT [] +synonym: "dibenzofuran degradation" EXACT [] +xref: MetaCyc:P662-PWY +is_a: GO:0018893 ! dibenzofuran metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019341 +name: dibenzo-p-dioxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai] +synonym: "dibenzo-p-dioxin breakdown" EXACT [] +synonym: "dibenzo-p-dioxin catabolism" EXACT [] +synonym: "dibenzo-p-dioxin degradation" EXACT [] +xref: MetaCyc:P661-PWY +is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019342 +name: trypanothione biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355] +synonym: "trypanothione anabolism" EXACT [] +synonym: "trypanothione biosynthesis" EXACT [] +synonym: "trypanothione formation" EXACT [] +synonym: "trypanothione synthesis" EXACT [] +xref: MetaCyc:TRYPANOSYN-PWY +is_a: GO:0046206 ! trypanothione metabolic process +is_a: GO:1901687 ! glutathione derivative biosynthetic process + +[Term] +id: GO:0019343 +name: cysteine biosynthetic process via cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] +synonym: "cysteine anabolism via cystathionine" EXACT [] +synonym: "cysteine formation via cystathionine" EXACT [] +synonym: "cysteine synthesis via cystathionine" EXACT [] +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0019344 +name: cysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] +synonym: "cysteine anabolism" EXACT [] +synonym: "cysteine biosynthesis" EXACT [] +synonym: "cysteine formation" EXACT [] +synonym: "cysteine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009070 ! serine family amino acid biosynthetic process + +[Term] +id: GO:0019345 +name: cysteine biosynthetic process via S-sulfo-L-cysteine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators] +synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT [] +synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT [] +synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT [] +synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT [] +synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT [] +is_a: GO:0019344 ! cysteine biosynthetic process + +[Term] +id: GO:0019346 +name: transsulfuration +namespace: biological_process +def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801] +synonym: "homocysteine-cysteine interconversion" NARROW [] +synonym: "transsulphuration" EXACT [] +xref: MetaCyc:PWY-801 +xref: Wikipedia:Transsulfuration_pathway +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0009092 ! homoserine metabolic process +is_a: GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0019347 +name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT [] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT [] +xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process + +[Term] +id: GO:0019348 +name: dolichol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] +synonym: "dolichol metabolism" EXACT [] +is_a: GO:0016093 ! polyprenol metabolic process + +[Term] +id: GO:0019349 +name: ribitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732] +synonym: "ribitol metabolism" EXACT [] +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019350 +name: teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732] +synonym: "teichoic acid anabolism" EXACT [] +synonym: "teichoic acid biosynthesis" EXACT [] +synonym: "teichoic acid formation" EXACT [] +synonym: "teichoic acid synthesis" EXACT [] +xref: MetaCyc:TEICHOICACID-PWY +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process +is_a: GO:0046374 ! teichoic acid metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0019351 +name: dethiobiotin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732] +synonym: "desthiobiotin biosynthesis" EXACT [] +synonym: "desthiobiotin biosynthetic process" EXACT [] +synonym: "dethiobiotin anabolism" EXACT [] +synonym: "dethiobiotin biosynthesis" EXACT [] +synonym: "dethiobiotin formation" EXACT [] +synonym: "dethiobiotin synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0046450 ! dethiobiotin metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0019352 +name: protoporphyrinogen IX biosynthetic process from glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators] +synonym: "protoporphyrinogen IX anabolism from glycine" EXACT [] +synonym: "protoporphyrinogen IX formation from glycine" EXACT [] +synonym: "protoporphyrinogen IX synthesis from glycine" EXACT [] +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process + +[Term] +id: GO:0019353 +name: protoporphyrinogen IX biosynthetic process from glutamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators] +synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT [] +synonym: "protoporphyrinogen IX formation from glutamate" EXACT [] +synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT [] +is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process +is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate + +[Term] +id: GO:0019354 +name: siroheme biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] +synonym: "sirohaem biosynthesis" EXACT [] +synonym: "sirohaem biosynthetic process" EXACT [] +synonym: "siroheme anabolism" EXACT [] +synonym: "siroheme biosynthesis" EXACT [] +synonym: "siroheme formation" EXACT [] +synonym: "siroheme synthase activity" RELATED [] +synonym: "siroheme synthesis" EXACT [] +xref: MetaCyc:PWY-5194 +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0046156 ! siroheme metabolic process + +[Term] +id: GO:0019355 +name: nicotinamide nucleotide biosynthetic process from aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators] +synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT [] +synonym: "nicotinamide nucleotide formation from aspartate" EXACT [] +synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT [] +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0019356 +name: nicotinate nucleotide biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators] +synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT [] +synonym: "nicotinate nucleotide formation from tryptophan" EXACT [] +synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process + +[Term] +id: GO:0019357 +name: nicotinate nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators] +synonym: "nicotinate nucleotide anabolism" EXACT [] +synonym: "nicotinate nucleotide biosynthesis" EXACT [] +synonym: "nicotinate nucleotide formation" EXACT [] +synonym: "nicotinate nucleotide synthesis" EXACT [] +is_a: GO:0019363 ! pyridine nucleotide biosynthetic process +is_a: GO:0046497 ! nicotinate nucleotide metabolic process + +[Term] +id: GO:0019358 +name: nicotinate nucleotide salvage +namespace: biological_process +def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] +synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT [] +synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT [] +xref: MetaCyc:PWY-5381 +xref: MetaCyc:PYRIDNUCSAL-PWY +is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process +is_a: GO:0019365 ! pyridine nucleotide salvage + +[Term] +id: GO:0019359 +name: nicotinamide nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators] +synonym: "nicotinamide nucleotide anabolism" EXACT [] +synonym: "nicotinamide nucleotide biosynthesis" EXACT [] +synonym: "nicotinamide nucleotide formation" EXACT [] +synonym: "nicotinamide nucleotide synthesis" EXACT [] +is_a: GO:0019363 ! pyridine nucleotide biosynthetic process +is_a: GO:0046496 ! nicotinamide nucleotide metabolic process + +[Term] +id: GO:0019360 +name: nicotinamide nucleotide biosynthetic process from niacinamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators] +synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT [] +synonym: "nicotinamide nucleotide formation from niacinamide" EXACT [] +synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT [] +is_a: GO:0006769 ! nicotinamide metabolic process +is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process + +[Term] +id: GO:0019361 +name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] +xref: MetaCyc:P2-PWY +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process + +[Term] +id: GO:0019362 +name: pyridine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] +synonym: "pyridine nucleotide metabolism" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0019363 +name: pyridine nucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] +synonym: "pyridine nucleotide anabolism" EXACT [] +synonym: "pyridine nucleotide biosynthesis" EXACT [] +synonym: "pyridine nucleotide formation" EXACT [] +synonym: "pyridine nucleotide synthesis" EXACT [] +xref: MetaCyc:PYRIDNUCSYN-PWY +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0019362 ! pyridine nucleotide metabolic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process + +[Term] +id: GO:0019364 +name: pyridine nucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] +synonym: "pyridine nucleotide breakdown" EXACT [] +synonym: "pyridine nucleotide catabolism" EXACT [] +synonym: "pyridine nucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0019362 ! pyridine nucleotide metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process + +[Term] +id: GO:0019365 +name: pyridine nucleotide salvage +namespace: biological_process +def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl] +synonym: "pyridine nucleotide cycling" EXACT [] +is_a: GO:0019363 ! pyridine nucleotide biosynthetic process +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0019367 +name: fatty acid elongation, saturated fatty acid +namespace: biological_process +def: "Elongation of a saturated fatty acid chain." [GOC:mah] +xref: MetaCyc:FASYN-ELONG-PWY +is_a: GO:0030497 ! fatty acid elongation + +[Term] +id: GO:0019368 +name: fatty acid elongation, unsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] +xref: MetaCyc:PWY0-862 +is_a: GO:0030497 ! fatty acid elongation + +[Term] +id: GO:0019369 +name: arachidonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732] +synonym: "arachidonic acid metabolism" EXACT [] +xref: Wikipedia:Arachidonic_acid +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0006690 ! icosanoid metabolic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0019370 +name: leukotriene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators] +synonym: "leukotriene anabolism" EXACT [] +synonym: "leukotriene biosynthesis" EXACT [] +synonym: "leukotriene formation" EXACT [] +synonym: "leukotriene synthesis" EXACT [] +xref: Wikipedia:Leukotriene#Leukotriene_synthesis +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0046456 ! icosanoid biosynthetic process + +[Term] +id: GO:0019371 +name: cyclooxygenase pathway +namespace: biological_process +def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273] +is_a: GO:0019369 ! arachidonic acid metabolic process +relationship: part_of GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0019372 +name: lipoxygenase pathway +namespace: biological_process +def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881] +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0006690 ! icosanoid metabolic process + +[Term] +id: GO:0019373 +name: epoxygenase P450 pathway +namespace: biological_process +def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511] +is_a: GO:0019369 ! arachidonic acid metabolic process + +[Term] +id: GO:0019374 +name: galactolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] +synonym: "galactolipid metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process + +[Term] +id: GO:0019375 +name: galactolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] +synonym: "galactolipid anabolism" EXACT [] +synonym: "galactolipid biosynthesis" EXACT [] +synonym: "galactolipid formation" EXACT [] +synonym: "galactolipid synthesis" EXACT [] +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0019374 ! galactolipid metabolic process + +[Term] +id: GO:0019376 +name: galactolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] +synonym: "galactolipid breakdown" EXACT [] +synonym: "galactolipid catabolism" EXACT [] +synonym: "galactolipid degradation" EXACT [] +is_a: GO:0019374 ! galactolipid metabolic process +is_a: GO:0019377 ! glycolipid catabolic process + +[Term] +id: GO:0019377 +name: glycolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [GOC:go_curators] +synonym: "glycolipid breakdown" EXACT [] +synonym: "glycolipid catabolism" EXACT [] +synonym: "glycolipid degradation" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0046466 ! membrane lipid catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0019379 +name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) +namespace: biological_process +def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl] +synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT [] +xref: MetaCyc:SO4ASSIM-PWY +is_a: GO:0000103 ! sulfate assimilation +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0019380 +name: 3-phenylpropionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai] +synonym: "3-phenylpropionate breakdown" EXACT [] +synonym: "3-phenylpropionate catabolism" EXACT [] +synonym: "3-phenylpropionate degradation" EXACT [] +xref: MetaCyc:HCAMHPDEG-PWY +xref: MetaCyc:P281-PWY +is_a: GO:0018962 ! 3-phenylpropionate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019381 +name: atrazine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, UM-BBD_pathwayID:atr] +synonym: "atrazine breakdown" EXACT [] +synonym: "atrazine catabolism" EXACT [] +synonym: "atrazine degradation" EXACT [] +xref: MetaCyc:P141-PWY +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0018873 ! atrazine metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process + +[Term] +id: GO:0019382 +name: carbon tetrachloride catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators] +synonym: "carbon tetrachloride breakdown" EXACT [] +synonym: "carbon tetrachloride catabolism" EXACT [] +synonym: "carbon tetrachloride degradation" EXACT [] +is_a: GO:0018885 ! carbon tetrachloride metabolic process +is_a: GO:0042206 ! halogenated hydrocarbon catabolic process + +[Term] +id: GO:0019383 +name: (+)-camphor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [UM-BBD_pathwayID:cam] +synonym: "(+)-camphor breakdown" EXACT [] +synonym: "(+)-camphor catabolism" EXACT [] +synonym: "(+)-camphor degradation" EXACT [] +xref: MetaCyc:P601-PWY +is_a: GO:0016100 ! monoterpenoid catabolic process +is_a: GO:0018882 ! (+)-camphor metabolic process +is_a: GO:0042182 ! ketone catabolic process + +[Term] +id: GO:0019384 +name: caprolactam catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [GOC:curators] +synonym: "caprolactam breakdown" EXACT [] +synonym: "caprolactam catabolism" EXACT [] +synonym: "caprolactam degradation" EXACT [] +xref: MetaCyc:P621-PWY +is_a: GO:0018883 ! caprolactam metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0072340 ! cellular lactam catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0019385 +name: methanogenesis, from acetate +namespace: biological_process +def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai] +synonym: "methane biosynthesis from acetate" EXACT [] +synonym: "methane biosynthetic process from acetate" EXACT [] +xref: MetaCyc:METH-ACETATE-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019386 +name: methanogenesis, from carbon dioxide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai] +synonym: "methane biosynthesis from carbon dioxide" EXACT [] +synonym: "methane biosynthetic process from carbon dioxide" EXACT [] +xref: MetaCyc:METHANOGENESIS-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019387 +name: methanogenesis, from methanol +namespace: biological_process +def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai] +synonym: "methane biosynthesis from methanol" EXACT [] +synonym: "methane biosynthetic process from methanol" EXACT [] +xref: MetaCyc:METHFORM-PWY +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:0019388 +name: galactose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732] +synonym: "galactose breakdown" EXACT [] +synonym: "galactose catabolism" EXACT [] +synonym: "galactose degradation" EXACT [] +xref: MetaCyc:GALDEG-PWY +is_a: GO:0006012 ! galactose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0019389 +name: glucuronoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732] +synonym: "glucuronide metabolic process" EXACT [] +synonym: "glucuronide metabolism" EXACT [] +synonym: "glucuronoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019390 +name: glucuronoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] +synonym: "glucuronide biosynthesis" EXACT [] +synonym: "glucuronide biosynthetic process" EXACT [] +synonym: "glucuronoside anabolism" EXACT [] +synonym: "glucuronoside biosynthesis" EXACT [] +synonym: "glucuronoside formation" EXACT [] +synonym: "glucuronoside synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0019389 ! glucuronoside metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0019391 +name: glucuronoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] +synonym: "glucuronide catabolic process" EXACT [] +synonym: "glucuronide catabolism" EXACT [] +synonym: "glucuronoside breakdown" EXACT [] +synonym: "glucuronoside catabolism" EXACT [] +synonym: "glucuronoside degradation" EXACT [] +xref: MetaCyc:GLUCUROCAT-PWY +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0019389 ! glucuronoside metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0019392 +name: glucarate metabolic process +namespace: biological_process +alt_id: GO:0019581 +def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732] +synonym: "glucarate metabolism" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process + +[Term] +id: GO:0019393 +name: glucarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732] +synonym: "glucarate anabolism" EXACT [] +synonym: "glucarate biosynthesis" EXACT [] +synonym: "glucarate formation" EXACT [] +synonym: "glucarate synthesis" EXACT [] +is_a: GO:0019392 ! glucarate metabolic process +is_a: GO:0019578 ! aldaric acid biosynthetic process + +[Term] +id: GO:0019394 +name: glucarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732] +synonym: "glucarate breakdown" EXACT [] +synonym: "glucarate catabolism" EXACT [] +synonym: "glucarate degradation" EXACT [] +xref: MetaCyc:GLUCARDEG-PWY +is_a: GO:0019392 ! glucarate metabolic process +is_a: GO:0019579 ! aldaric acid catabolic process + +[Term] +id: GO:0019395 +name: fatty acid oxidation +namespace: biological_process +def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY] +xref: MetaCyc:FAO-PWY +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0034440 ! lipid oxidation + +[Term] +id: GO:0019396 +name: gallate catabolic process +namespace: biological_process +alt_id: GO:0018918 +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl] +synonym: "gallate breakdown" EXACT [] +synonym: "gallate catabolism" EXACT [] +synonym: "gallate degradation" EXACT [] +synonym: "gallate metabolic process" RELATED [] +synonym: "gallate metabolism" RELATED [] +synonym: "gallic acid catabolic process" EXACT [] +synonym: "gallic acid catabolism" EXACT [] +synonym: "gallic acid metabolic process" RELATED [] +synonym: "gallic acid metabolism" RELATED [] +xref: UM-BBD_pathwayID:gal +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0019397 +name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl] +synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT [] +synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT [] +xref: MetaCyc:GALLATE-DEGRADATION-I-PWY +is_a: GO:0042195 ! aerobic gallate catabolic process + +[Term] +id: GO:0019398 +name: gallate catabolic process via gallate dioxygenase activity +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase." [GOC:bf, GOC:jl] +synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" BROAD [GOC:bf] +synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] +xref: MetaCyc:GALLATE-DEGRADATION-II-PWY +is_a: GO:0042195 ! aerobic gallate catabolic process + +[Term] +id: GO:0019399 +name: cyclohexanol oxidation +namespace: biological_process +def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY] +xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY +is_a: GO:0018891 ! cyclohexanol metabolic process + +[Term] +id: GO:0019400 +name: alditol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] +synonym: "alditol metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019401 +name: alditol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] +synonym: "alditol anabolism" EXACT [] +synonym: "alditol biosynthesis" EXACT [] +synonym: "alditol formation" EXACT [] +synonym: "alditol synthesis" EXACT [] +is_a: GO:0019400 ! alditol metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process + +[Term] +id: GO:0019402 +name: galactitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] +synonym: "galactitol metabolism" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0019403 +name: galactitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] +synonym: "galactitol anabolism" EXACT [] +synonym: "galactitol biosynthesis" EXACT [] +synonym: "galactitol formation" EXACT [] +synonym: "galactitol synthesis" EXACT [] +is_a: GO:0019402 ! galactitol metabolic process +is_a: GO:0019406 ! hexitol biosynthetic process + +[Term] +id: GO:0019404 +name: galactitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] +synonym: "galactitol breakdown" EXACT [] +synonym: "galactitol catabolism" EXACT [] +synonym: "galactitol degradation" EXACT [] +xref: MetaCyc:GALACTITOLCAT-PWY +is_a: GO:0019402 ! galactitol metabolic process +is_a: GO:0019407 ! hexitol catabolic process + +[Term] +id: GO:0019405 +name: alditol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] +synonym: "alditol breakdown" EXACT [] +synonym: "alditol catabolism" EXACT [] +synonym: "alditol degradation" EXACT [] +is_a: GO:0019400 ! alditol metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0019406 +name: hexitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexitol anabolism" EXACT [] +synonym: "hexitol biosynthesis" EXACT [] +synonym: "hexitol formation" EXACT [] +synonym: "hexitol synthesis" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process +is_a: GO:0019401 ! alditol biosynthetic process + +[Term] +id: GO:0019407 +name: hexitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] +synonym: "hexitol breakdown" EXACT [] +synonym: "hexitol catabolism" EXACT [] +synonym: "hexitol degradation" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process +is_a: GO:0019405 ! alditol catabolic process + +[Term] +id: GO:0019408 +name: dolichol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] +synonym: "dolichol anabolism" EXACT [] +synonym: "dolichol biosynthesis" EXACT [] +synonym: "dolichol formation" EXACT [] +synonym: "dolichol synthesis" EXACT [] +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0019348 ! dolichol metabolic process + +[Term] +id: GO:0019409 +name: aerobic respiration, using ammonia as electron donor +namespace: biological_process +def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY] +synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah] +xref: MetaCyc:AMMOXID-PWY +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds +is_a: GO:0019329 ! ammonia oxidation +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0019410 +name: aerobic respiration, using carbon monoxide as electron donor +namespace: biological_process +def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019411 +name: aerobic respiration, using ferrous ions as electron donor +namespace: biological_process +def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019412 +name: aerobic respiration, using hydrogen as electron donor +namespace: biological_process +def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY] +synonym: "hydrogen oxidation" BROAD [] +xref: MetaCyc:P283-PWY +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019413 +name: acetate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "acetate anabolism" EXACT [] +synonym: "acetate biosynthesis" EXACT [] +synonym: "acetate formation" EXACT [] +synonym: "acetate synthesis" EXACT [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0019414 +name: aerobic respiration, using sulfur or sulfate as electron donor +namespace: biological_process +def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697] +synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT [] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0019415 +name: acetate biosynthetic process from carbon monoxide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators] +synonym: "acetate anabolism from carbon monoxide" EXACT [] +synonym: "acetate formation from carbon monoxide" EXACT [] +synonym: "acetate synthesis from carbon monoxide" EXACT [] +synonym: "carbon monoxide dehydrogenase pathway" EXACT [] +is_a: GO:0019413 ! acetate biosynthetic process + +[Term] +id: GO:0019416 +name: polythionate oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY] +xref: MetaCyc:THIOSULFOX-PWY +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019417 +name: sulfur oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] +synonym: "sulphur oxidation" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019418 +name: sulfide oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] +synonym: "sulphide oxidation" EXACT [] +xref: MetaCyc:P222-PWY +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019419 +name: sulfate reduction +namespace: biological_process +alt_id: GO:0019421 +def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY] +synonym: "assimilatory sulfate reduction" NARROW [] +synonym: "assimilatory sulphate reduction" NARROW [] +synonym: "sulfate reduction, APS pathway" NARROW [] +synonym: "sulphate reduction" EXACT [] +synonym: "sulphate reduction, APS pathway" NARROW [] +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019420 +name: dissimilatory sulfate reduction +namespace: biological_process +def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] +synonym: "dissimilatory sulphate reduction" EXACT [] +xref: MetaCyc:DISSULFRED-PWY +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0019422 +name: disproportionation of elemental sulfur +namespace: biological_process +def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY] +synonym: "disproportionation of elemental sulphur" EXACT [] +xref: MetaCyc:P203-PWY +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0019423 +name: sulfur oxidation, ferric ion-dependent +namespace: biological_process +def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY] +synonym: "sulphur oxidation, ferric ion-dependent" EXACT [] +xref: MetaCyc:FESULFOX-PWY +is_a: GO:0019417 ! sulfur oxidation + +[Term] +id: GO:0019424 +name: sulfide oxidation, using siroheme sulfite reductase +namespace: biological_process +alt_id: GO:0019425 +def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY] +synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT [] +synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED [] +synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED [] +synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT [] +synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED [] +xref: MetaCyc:P223-PWY +is_a: GO:0019418 ! sulfide oxidation + +[Term] +id: GO:0019426 +name: bisulfite reduction +namespace: biological_process +def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY] +synonym: "bisulphite reduction" EXACT [] +xref: MetaCyc:P224-PWY +is_a: GO:0019419 ! sulfate reduction + +[Term] +id: GO:0019427 +name: acetyl-CoA biosynthetic process from acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY] +synonym: "acetate utilization" RELATED [] +synonym: "acetyl-CoA anabolism from acetate" EXACT [] +synonym: "acetyl-CoA formation from acetate" EXACT [] +synonym: "acetyl-CoA synthesis from acetate" EXACT [] +xref: MetaCyc:ACETATEUTIL-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0006085 ! acetyl-CoA biosynthetic process + +[Term] +id: GO:0019428 +name: allantoin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators] +synonym: "allantoin anabolism" EXACT [] +synonym: "allantoin biosynthesis" EXACT [] +synonym: "allantoin formation" EXACT [] +synonym: "allantoin synthesis" EXACT [] +xref: MetaCyc:URSIN-PWY +is_a: GO:0000255 ! allantoin metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0019429 +name: fluorene catabolic process +namespace: biological_process +alt_id: GO:0018917 +def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [PMID:15317800] +synonym: "fluorene breakdown" EXACT [] +synonym: "fluorene catabolism" EXACT [] +synonym: "fluorene degradation" EXACT [] +synonym: "fluorene metabolic process" NARROW [] +synonym: "fluorene metabolism" EXACT [] +xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY +xref: UM-BBD_pathwayID:flu +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019430 +name: removal of superoxide radicals +namespace: biological_process +def: "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [GOC:jl] +synonym: "cellular detoxification of superoxide radicals" EXACT [GOC:dos] +synonym: "removal of O2-" EXACT [] +synonym: "removal of oxygen free radicals" EXACT [] +xref: MetaCyc:DETOX1-PWY +is_a: GO:0006801 ! superoxide metabolic process +is_a: GO:0098869 ! cellular oxidant detoxification +relationship: part_of GO:0071451 ! cellular response to superoxide + +[Term] +id: GO:0019431 +name: acetyl-CoA biosynthetic process from ethanol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators] +synonym: "acetyl-CoA anabolism from ethanol" EXACT [] +synonym: "acetyl-CoA formation from ethanol" EXACT [] +synonym: "acetyl-CoA synthesis from ethanol" EXACT [] +xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0006085 ! acetyl-CoA biosynthetic process + +[Term] +id: GO:0019432 +name: triglyceride biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732] +synonym: "triacylglycerol biosynthesis" EXACT [] +synonym: "triacylglycerol biosynthetic process" EXACT [] +synonym: "triglyceride anabolism" EXACT [] +synonym: "triglyceride biosynthesis" EXACT [] +synonym: "triglyceride formation" EXACT [] +synonym: "triglyceride synthesis" EXACT [] +xref: MetaCyc:TRIGLSYN-PWY +is_a: GO:0006641 ! triglyceride metabolic process +is_a: GO:0046463 ! acylglycerol biosynthetic process + +[Term] +id: GO:0019433 +name: triglyceride catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] +synonym: "triacylglycerol catabolic process" EXACT [] +synonym: "triacylglycerol catabolism" EXACT [] +synonym: "triglyceride breakdown" EXACT [] +synonym: "triglyceride catabolism" EXACT [] +synonym: "triglyceride degradation" EXACT [] +xref: MetaCyc:LIPAS-PWY +is_a: GO:0006641 ! triglyceride metabolic process +is_a: GO:0046464 ! acylglycerol catabolic process + +[Term] +id: GO:0019434 +name: sophorosyloxydocosanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] +synonym: "sophorosyloxydocosanoate metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process + +[Term] +id: GO:0019435 +name: sophorosyloxydocosanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] +synonym: "sophorosyloxydocosanoate anabolism" EXACT [] +synonym: "sophorosyloxydocosanoate biosynthesis" EXACT [] +synonym: "sophorosyloxydocosanoate formation" EXACT [] +synonym: "sophorosyloxydocosanoate synthesis" EXACT [] +xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process + +[Term] +id: GO:0019436 +name: sophorosyloxydocosanoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] +synonym: "sophorosyloxydocosanoate breakdown" EXACT [] +synonym: "sophorosyloxydocosanoate catabolism" EXACT [] +synonym: "sophorosyloxydocosanoate degradation" EXACT [] +xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY +is_a: GO:0019377 ! glycolipid catabolic process +is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process + +[Term] +id: GO:0019438 +name: aromatic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] +synonym: "aromatic compound anabolism" EXACT [] +synonym: "aromatic compound biosynthesis" EXACT [] +synonym: "aromatic compound formation" EXACT [] +synonym: "aromatic compound synthesis" EXACT [] +synonym: "aromatic hydrocarbon biosynthesis" NARROW [] +synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0019439 +name: aromatic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] +synonym: "aromatic compound breakdown" EXACT [] +synonym: "aromatic compound catabolism" EXACT [] +synonym: "aromatic compound degradation" EXACT [] +synonym: "aromatic hydrocarbon catabolic process" NARROW [] +synonym: "aromatic hydrocarbon catabolism" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0019440 +name: tryptophan catabolic process to indole-3-acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators] +synonym: "tryptophan breakdown to indole-3-acetate" EXACT [] +synonym: "tryptophan catabolic process to IAA" EXACT [] +synonym: "tryptophan catabolic process to indoleacetic acid" EXACT [] +synonym: "tryptophan catabolism to indoleacetic acid" EXACT [] +synonym: "tryptophan degradation to indole-3-acetate" EXACT [] +xref: MetaCyc:TRPIAACAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process +is_a: GO:0009683 ! indoleacetic acid metabolic process + +[Term] +id: GO:0019441 +name: tryptophan catabolic process to kynurenine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] +synonym: "tryptophan breakdown to kynurenine" EXACT [] +synonym: "tryptophan degradation to kynurenine" EXACT [] +xref: MetaCyc:TRPKYNCAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process +is_a: GO:0070189 ! kynurenine metabolic process + +[Term] +id: GO:0019442 +name: tryptophan catabolic process to acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators] +synonym: "tryptophan breakdown to acetyl-CoA" EXACT [] +synonym: "tryptophan degradation to acetyl-CoA" EXACT [] +xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1 +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0006569 ! tryptophan catabolic process + +[Term] +id: GO:0019443 +name: obsolete tryptophan catabolic process, using tryptophanase +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl] +comment: This term was made obsolete because it refers to a one-step pathway. +synonym: "tryptophan breakdown, using tryptophanase" EXACT [] +synonym: "tryptophan catabolic process, using tryptophanase" EXACT [] +synonym: "tryptophan degradation, using tryptophanase" EXACT [] +is_obsolete: true +consider: GO:0006569 +consider: GO:0009034 + +[Term] +id: GO:0019444 +name: tryptophan catabolic process to catechol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators] +synonym: "tryptophan breakdown to catechol" EXACT [] +synonym: "tryptophan degradation to catechol" EXACT [] +xref: MetaCyc:TRPCAT-PWY +is_a: GO:0006569 ! tryptophan catabolic process +is_a: GO:0009712 ! catechol-containing compound metabolic process + +[Term] +id: GO:0019445 +name: tyrosine catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators] +synonym: "tyrosine breakdown to fumarate" EXACT [] +synonym: "tyrosine degradation to fumarate" EXACT [] +xref: MetaCyc:TYRFUMCAT-PWY +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006572 ! tyrosine catabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019446 +name: obsolete tyrosine catabolic process to phosphoenolpyruvate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] +comment: The reason for obsoletion is that there is no evidence that this is a real process. +synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT [] +synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019447 +name: D-cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [PMID:11527960] +synonym: "D-cysteine breakdown" EXACT [] +synonym: "D-cysteine catabolism" EXACT [] +synonym: "D-cysteine degradation" EXACT [] +is_a: GO:0009093 ! cysteine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0046438 ! D-cysteine metabolic process + +[Term] +id: GO:0019448 +name: L-cysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:jsg, GOC:mah] +synonym: "L-cysteine breakdown" EXACT [] +synonym: "L-cysteine catabolism" EXACT [] +synonym: "L-cysteine degradation" EXACT [] +is_a: GO:0009093 ! cysteine catabolic process +is_a: GO:0046439 ! L-cysteine metabolic process + +[Term] +id: GO:0019449 +name: L-cysteine catabolic process to hypotaurine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] +synonym: "L-cysteine breakdown to hypotaurine" EXACT [] +synonym: "L-cysteine degradation to hypotaurine" EXACT [] +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019450 +name: L-cysteine catabolic process to pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators] +synonym: "L-cysteine breakdown to pyruvate" EXACT [] +synonym: "L-cysteine degradation to pyruvate" EXACT [] +xref: MetaCyc:LCYSDEG-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019451 +name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl] +synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT [] +synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT [] +xref: MetaCyc:CYSTEINE-DEG-PWY +is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate + +[Term] +id: GO:0019452 +name: L-cysteine catabolic process to taurine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] +synonym: "L-cysteine breakdown to taurine" EXACT [] +synonym: "L-cysteine degradation to taurine" EXACT [] +is_a: GO:0019448 ! L-cysteine catabolic process +is_a: GO:0019530 ! taurine metabolic process + +[Term] +id: GO:0019453 +name: L-cysteine catabolic process via cystine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators] +synonym: "L-cysteine breakdown via cystine" EXACT [] +synonym: "L-cysteine degradation via cystine" EXACT [] +is_a: GO:0019448 ! L-cysteine catabolic process + +[Term] +id: GO:0019454 +name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase." [GOC:jl] +synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT [] +synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT [] +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019455 +name: L-cysteine catabolic process via cystine, using cystine reductase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase." [GOC:jl] +synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT [] +synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT [] +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019456 +name: L-cysteine catabolic process via cystine, using cysteine transaminase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase." [GOC:jl] +synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT [] +synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT [] +is_a: GO:0019453 ! L-cysteine catabolic process via cystine + +[Term] +id: GO:0019457 +name: methionine catabolic process to succinyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators] +synonym: "methionine breakdown to succinyl-CoA" EXACT [] +synonym: "methionine degradation to succinyl-CoA" EXACT [] +xref: MetaCyc:METHIONINE-DEG1-PWY +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0019458 +name: methionine catabolic process via 2-oxobutanoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators] +synonym: "methionine breakdown via 2-oxobutanoate" EXACT [] +synonym: "methionine degradation via 2-oxobutanoate" EXACT [] +xref: MetaCyc:PWY-701 +is_a: GO:0009087 ! methionine catabolic process + +[Term] +id: GO:0019460 +name: glutamine catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators] +synonym: "glutamate catabolic process to fumarate" NARROW [GOC:bf, GOC:jl] +synonym: "glutamine breakdown to fumarate" EXACT [] +synonym: "glutamine degradation to fumarate" EXACT [] +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0006543 ! glutamine catabolic process + +[Term] +id: GO:0019461 +name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH) +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl] +synonym: "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)" RELATED [GOC:bf, GOC:jl] +synonym: "glutamine breakdown to fumarate, using glutamate synthase (NADPH)" EXACT [] +synonym: "glutamine degradation to fumarate, using glutamate synthase (NADPH)" EXACT [] +xref: MetaCyc:GLUTAMINEFUM-PWY +is_a: GO:0019460 ! glutamine catabolic process to fumarate + +[Term] +id: GO:0019462 +name: glutamine catabolic process to fumarate, using glutaminase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl] +synonym: "glutamate catabolic process to fumarate, using glutaminase" RELATED [GOC:bf, GOC:jl] +synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT [] +synonym: "glutamine degradation to fumarate, using glutaminase" NARROW [] +xref: MetaCyc:GLUTAMINDEG-PWY +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019463 +name: glycine catabolic process to creatine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators] +synonym: "glycine breakdown to creatine" EXACT [] +synonym: "glycine degradation to creatine" EXACT [] +xref: MetaCyc:GLYCGREAT-PWY +is_a: GO:0006546 ! glycine catabolic process +is_a: GO:0006600 ! creatine metabolic process + +[Term] +id: GO:0019464 +name: glycine decarboxylation via glycine cleavage system +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] +synonym: "glycine cleavage system" BROAD [] +xref: MetaCyc:GLYCLEAV-PWY +is_a: GO:0006546 ! glycine catabolic process + +[Term] +id: GO:0019465 +name: aspartate transamidation +namespace: biological_process +def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732] +xref: MetaCyc:ASPARTATE-DEG1-PWY +xref: MetaCyc:ASPARTATESYN-PWY +is_a: GO:0006533 ! aspartate catabolic process + +[Term] +id: GO:0019466 +name: ornithine catabolic process via proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators] +synonym: "ornithine breakdown via proline" EXACT [] +synonym: "ornithine degradation via proline" EXACT [] +xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:0019467 +name: ornithine catabolic process, by decarboxylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators] +synonym: "ornithine breakdown, by decarboxylation" EXACT [] +synonym: "ornithine degradation, by decarboxylation" EXACT [] +xref: MetaCyc:ORNDEG-PWY +is_a: GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:0019468 +name: nopaline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732] +synonym: "nopaline breakdown" EXACT [] +synonym: "nopaline catabolism" EXACT [] +synonym: "nopaline degradation" EXACT [] +xref: MetaCyc:NOPALINEDEG-PWY +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046418 ! nopaline metabolic process + +[Term] +id: GO:0019469 +name: octopine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732] +synonym: "octopine breakdown" EXACT [] +synonym: "octopine catabolism" EXACT [] +synonym: "octopine degradation" EXACT [] +xref: MetaCyc:OCTOPINEDEG-PWY +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046419 ! octopine metabolic process + +[Term] +id: GO:0019470 +name: 4-hydroxyproline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] +synonym: "4-hydroxyproline breakdown" EXACT [] +synonym: "4-hydroxyproline catabolism" EXACT [] +synonym: "4-hydroxyproline degradation" EXACT [] +xref: MetaCyc:HYDROXYPRODEG-PWY +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0019471 ! 4-hydroxyproline metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0019471 +name: 4-hydroxyproline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [GOC:ai] +synonym: "4-hydroxyproline metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0019472 +name: 4-hydroxyproline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] +synonym: "4-hydroxyproline anabolism" EXACT [] +synonym: "4-hydroxyproline biosynthesis" EXACT [] +synonym: "4-hydroxyproline formation" EXACT [] +synonym: "4-hydroxyproline synthesis" EXACT [] +is_a: GO:0019471 ! 4-hydroxyproline metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0019473 +name: L-lysine catabolic process to glutarate, by acetylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators] +synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT [] +synonym: "L-lysine degradation to glutarate, by acetylation" EXACT [] +xref: MetaCyc:LYSDEGII-PWY +is_a: GO:0019477 ! L-lysine catabolic process + +[Term] +id: GO:0019474 +name: L-lysine catabolic process to acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators] +synonym: "L-lysine breakdown to acetyl-CoA" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0019477 ! L-lysine catabolic process + +[Term] +id: GO:0019475 +name: L-lysine catabolic process to acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators] +synonym: "L-lysine breakdown to acetate" EXACT [] +synonym: "L-lysine degradation to acetate" EXACT [] +synonym: "lysine fermentation" EXACT [] +xref: MetaCyc:P163-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0019477 ! L-lysine catabolic process +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019476 +name: D-lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-lysine breakdown" EXACT [] +synonym: "D-lysine catabolism" EXACT [] +synonym: "D-lysine degradation" EXACT [] +is_a: GO:0006554 ! lysine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0046441 ! D-lysine metabolic process + +[Term] +id: GO:0019477 +name: L-lysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah] +synonym: "L-lysine breakdown" EXACT [] +synonym: "L-lysine catabolism" EXACT [] +synonym: "L-lysine degradation" EXACT [] +is_a: GO:0006554 ! lysine catabolic process +is_a: GO:0046440 ! L-lysine metabolic process + +[Term] +id: GO:0019478 +name: D-amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] +synonym: "D-amino acid breakdown" EXACT [] +synonym: "D-amino acid catabolism" EXACT [] +synonym: "D-amino acid degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0046416 ! D-amino acid metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0019479 +name: L-alanine oxidation to D-lactate and ammonia +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY] +xref: MetaCyc:ALACAT2-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019480 +name: L-alanine oxidation to pyruvate via D-alanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY] +xref: MetaCyc:ALADEG-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019481 +name: L-alanine catabolic process, by transamination +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators] +synonym: "L-alanine breakdown, by transamination" EXACT [] +synonym: "L-alanine degradation, by transamination" EXACT [] +xref: MetaCyc:ALANINE-DEG3-PWY +is_a: GO:0042853 ! L-alanine catabolic process + +[Term] +id: GO:0019482 +name: beta-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] +synonym: "beta-alanine metabolism" EXACT [] +xref: Wikipedia:Beta-alanine +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0019483 +name: beta-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] +synonym: "beta-alanine anabolism" EXACT [] +synonym: "beta-alanine biosynthesis" EXACT [] +synonym: "beta-alanine formation" EXACT [] +synonym: "beta-alanine synthesis" EXACT [] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0019482 ! beta-alanine metabolic process + +[Term] +id: GO:0019484 +name: beta-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] +synonym: "beta-alanine breakdown" EXACT [] +synonym: "beta-alanine catabolism" EXACT [] +synonym: "beta-alanine degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0019482 ! beta-alanine metabolic process + +[Term] +id: GO:0019485 +name: beta-alanine catabolic process to L-alanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators] +synonym: "beta-alanine breakdown to L-alanine" EXACT [] +synonym: "beta-alanine degradation to L-alanine" EXACT [] +is_a: GO:0019484 ! beta-alanine catabolic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0019486 +name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators] +synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT [] +synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT [] +xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY +is_a: GO:0019484 ! beta-alanine catabolic process + +[Term] +id: GO:0019487 +name: anaerobic acetylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544] +synonym: "anaerobic acetylene breakdown" EXACT [] +synonym: "anaerobic acetylene catabolism" EXACT [] +synonym: "anaerobic acetylene degradation" EXACT [] +synonym: "anaerobic ethyne catabolic process" EXACT [] +synonym: "anaerobic ethyne catabolism" EXACT [] +xref: MetaCyc:P161-PWY +is_a: GO:0018864 ! acetylene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043454 ! alkyne catabolic process +is_a: GO:0120245 ! terminal acetylenic compound catabolic process + +[Term] +id: GO:0019488 +name: ribitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY] +synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "ribitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "ribitol utilization" RELATED [] +xref: MetaCyc:RIBITOLUTIL-PWY +is_a: GO:0046363 ! ribitol catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019489 +name: methylgallate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +synonym: "methylgallate metabolism" EXACT [] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0019490 +name: 2-aminobenzenesulfonate desulfonation +namespace: biological_process +def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] +synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] +xref: MetaCyc:2ASDEG-PWY +is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process + +[Term] +id: GO:0019491 +name: ectoine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +synonym: "ectoine anabolism" EXACT [] +synonym: "ectoine biosynthesis" EXACT [] +synonym: "ectoine formation" EXACT [] +synonym: "ectoine synthesis" EXACT [] +xref: MetaCyc:P101-PWY +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042399 ! ectoine metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0019492 +name: proline salvage +namespace: biological_process +def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl] +synonym: "proline cycling" EXACT [] +is_a: GO:0006561 ! proline biosynthetic process +is_a: GO:0043102 ! amino acid salvage + +[Term] +id: GO:0019493 +name: arginine catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] +synonym: "arginine breakdown to proline" EXACT [] +synonym: "arginine degradation to proline" EXACT [] +xref: MetaCyc:ARG-PRO-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006560 ! proline metabolic process + +[Term] +id: GO:0019495 +name: proline catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators] +synonym: "proline breakdown to 2-oxoglutarate" EXACT [] +synonym: "proline catabolic process to 2-ketoglutarate" EXACT [] +synonym: "proline catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "proline catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "proline catabolism to 2-ketoglutarate" EXACT [] +synonym: "proline catabolism to alpha-ketoglutarate" EXACT [] +synonym: "proline catabolism to alpha-oxoglutarate" EXACT [] +synonym: "proline degradation to 2-oxoglutarate" EXACT [] +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006562 ! proline catabolic process + +[Term] +id: GO:0019496 +name: serine-isocitrate lyase pathway +namespace: biological_process +def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534] +is_a: GO:0006730 ! one-carbon metabolic process + +[Term] +id: GO:0019497 +name: hexachlorocyclohexane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] +synonym: "hexachlorocyclohexane metabolism" EXACT [] +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process + +[Term] +id: GO:0019498 +name: n-octane oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY] +xref: MetaCyc:P221-PWY +is_a: GO:0018939 ! n-octane metabolic process + +[Term] +id: GO:0019499 +name: cyanide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732] +synonym: "cyanide metabolism" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0019500 +name: cyanide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732] +synonym: "cyanide breakdown" EXACT [] +synonym: "cyanide catabolism" EXACT [] +synonym: "cyanide degradation" EXACT [] +xref: MetaCyc:P401-PWY +is_a: GO:0019499 ! cyanide metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0019501 +name: arsonoacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl] +synonym: "arsonoacetate breakdown" EXACT [] +synonym: "arsonoacetate catabolism" EXACT [] +synonym: "arsonoacetate degradation" EXACT [] +xref: MetaCyc:P482-PWY +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0018872 ! arsonoacetate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0019502 +name: stachydrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators, MetaCyc:CPD-821] +synonym: "stachydrine metabolism" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0019503 +name: stachydrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] +synonym: "stachydrine anabolism" EXACT [] +synonym: "stachydrine biosynthesis" EXACT [] +synonym: "stachydrine formation" EXACT [] +synonym: "stachydrine synthesis" EXACT [] +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0019502 ! stachydrine metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0019504 +name: stachydrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] +synonym: "stachydrine breakdown" EXACT [] +synonym: "stachydrine catabolism" EXACT [] +synonym: "stachydrine degradation" EXACT [] +xref: MetaCyc:P561-PWY +is_a: GO:0006579 ! amino-acid betaine catabolic process +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0019502 ! stachydrine metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0019505 +name: resorcinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm] +synonym: "1,3-benzenediol metabolic process" EXACT [] +synonym: "1,3-benzenediol metabolism" EXACT [] +synonym: "1,3-dihydroxybenzene metabolic process" EXACT [] +synonym: "1,3-dihydroxybenzene metabolism" EXACT [] +synonym: "resorcinol metabolism" EXACT [] +xref: MetaCyc:P343-PWY +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0019506 +name: phenylmercury acetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] +synonym: "phenylmercury acetate breakdown" EXACT [] +synonym: "phenylmercury acetate catabolism" EXACT [] +synonym: "phenylmercury acetate degradation" EXACT [] +xref: MetaCyc:P641-PWY +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046412 ! phenylmercury acetate metabolic process +is_a: GO:0046413 ! organomercury catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019507 +name: pyridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:curators] +synonym: "pyridine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0019508 +name: 2,5-dihydroxypyridine catabolic process to fumarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722] +synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT [] +synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT [] +synonym: "2,5-dihydroxypyridine utilization" RELATED [] +synonym: "maleamate pathway" EXACT [] +synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT [] +xref: MetaCyc:PWY-722 +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process + +[Term] +id: GO:0019509 +name: L-methionine salvage from methylthioadenosine +namespace: biological_process +def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361] +synonym: "methionine recycling" NARROW [] +synonym: "methionine regeneration" NARROW [] +synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah] +synonym: "methionine salvage pathway" EXACT [] +xref: MetaCyc:PWY-4361 +is_a: GO:0071267 ! L-methionine salvage + +[Term] +id: GO:0019510 +name: S-adenosylhomocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732] +synonym: "S-adenosylhomocysteine breakdown" EXACT [] +synonym: "S-adenosylhomocysteine catabolism" EXACT [] +synonym: "S-adenosylhomocysteine degradation" EXACT [] +xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046130 ! purine ribonucleoside catabolic process +is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0019511 +name: peptidyl-proline hydroxylation +namespace: biological_process +alt_id: GO:0006472 +def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0019512 +name: lactose catabolic process via tagatose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators] +synonym: "lactose breakdown via tagatose-6-phosphate" EXACT [] +synonym: "lactose degradation via tagatose-6-phosphate" EXACT [] +xref: MetaCyc:LACTOSECAT-PWY +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019513 +name: lactose catabolic process, using glucoside 3-dehydrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase." [GOC:jl] +synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT [] +synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT [] +xref: MetaCyc:LACTOSEUTIL-PWY +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019514 +name: obsolete lactose hydrolysis +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because hydrolysis is a reaction. +synonym: "lactose hydrolysis" EXACT [] +is_obsolete: true +consider: GO:0004565 + +[Term] +id: GO:0019515 +name: lactose catabolic process via UDP-galactose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators] +synonym: "lactose breakdown via UDP-galactose" EXACT [] +synonym: "lactose degradation via UDP-galactose" EXACT [] +is_a: GO:0005990 ! lactose catabolic process + +[Term] +id: GO:0019516 +name: lactate oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah] +is_a: GO:0006089 ! lactate metabolic process + +[Term] +id: GO:0019517 +name: L-threonine catabolic process to D-lactate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY] +synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf] +synonym: "L-threonine catabolic process to (R)-lactate" BROAD [GOC:bf] +synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] +synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] +synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf] +synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] +xref: MetaCyc:THRDLCTCAT-PWY +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0006567 ! threonine catabolic process + +[Term] +id: GO:0019518 +name: L-threonine catabolic process to glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine." [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY] +synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] +synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah] +synonym: "threonine catabolic process to glycine" BROAD [GOC:bf] +xref: MetaCyc:THREONINE-DEG2-PWY +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0006567 ! threonine catabolic process + +[Term] +id: GO:0019519 +name: pentitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentitol metabolism" EXACT [] +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0019520 +name: aldonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] +synonym: "aldonic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0019521 +name: D-gluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "D-gluconate metabolism" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019522 +name: ketogluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] +synonym: "ketogluconate metabolism" EXACT [] +xref: MetaCyc:KETOGLUCONMET-PWY +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019523 +name: L-idonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] +synonym: "L-idonate metabolism" EXACT [] +xref: MetaCyc:IDNCAT-PWY +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019524 +name: keto-D-gluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "keto-D-gluconate breakdown" EXACT [] +synonym: "keto-D-gluconate catabolism" EXACT [] +synonym: "keto-D-gluconate degradation" EXACT [] +xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY +is_a: GO:0019525 ! keto-D-gluconate metabolic process +is_a: GO:0046181 ! ketogluconate catabolic process + +[Term] +id: GO:0019525 +name: keto-D-gluconate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "keto-D-gluconate metabolism" EXACT [] +is_a: GO:0019522 ! ketogluconate metabolic process + +[Term] +id: GO:0019526 +name: pentitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentitol anabolism" EXACT [] +synonym: "pentitol biosynthesis" EXACT [] +synonym: "pentitol formation" EXACT [] +synonym: "pentitol synthesis" EXACT [] +is_a: GO:0019401 ! alditol biosynthetic process +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019527 +name: pentitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentitol breakdown" EXACT [] +synonym: "pentitol catabolism" EXACT [] +synonym: "pentitol degradation" EXACT [] +is_a: GO:0019405 ! alditol catabolic process +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0019528 +name: D-arabitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY] +synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "D-arabitol degradation" RELATED [] +synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "D-arabitol utilization" RELATED [] +xref: MetaCyc:DARABITOLUTIL-PWY +is_a: GO:0051159 ! D-arabitol catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019529 +name: taurine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +synonym: "taurine breakdown" EXACT [] +synonym: "taurine catabolism" EXACT [] +synonym: "taurine degradation" EXACT [] +xref: MetaCyc:TAURINEDEG-PWY +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019530 ! taurine metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046306 ! alkanesulfonate catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0019530 +name: taurine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +synonym: "taurine metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0019531 +name: oxalate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] +synonym: "oxalic acid transporter activity" EXACT [] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0019532 +name: oxalate transport +namespace: biological_process +def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] +synonym: "ethanedioate transport" EXACT [] +synonym: "ethanedioic acid transport" EXACT [] +synonym: "oxalic acid transport" EXACT [] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0019533 +name: cellobiose transport +namespace: biological_process +def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:0019534 +name: toxin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0019535 +name: ferric-vibriobactin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] +is_a: GO:0015603 ! iron chelate transmembrane transporter activity + +[Term] +id: GO:0019536 +name: vibriobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] +synonym: "vibriobactin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0019537 +name: vibriobactin biosynthetic process +namespace: biological_process +alt_id: GO:0031195 +alt_id: GO:0031196 +def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] +synonym: "vibriobactin anabolism" EXACT [] +synonym: "vibriobactin biosynthesis" EXACT [] +synonym: "vibriobactin biosynthetic process, peptide formation" NARROW [] +synonym: "vibriobactin biosynthetic process, peptide modification" NARROW [] +synonym: "vibriobactin formation" EXACT [] +synonym: "vibriobactin synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019536 ! vibriobactin metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0019538 +name: protein metabolic process +namespace: biological_process +alt_id: GO:0006411 +alt_id: GO:0044268 +def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] +subset: goslim_agr +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +synonym: "multicellular organismal protein metabolic process" NARROW [] +synonym: "protein metabolic process and modification" EXACT [] +synonym: "protein metabolism" EXACT [] +synonym: "protein metabolism and modification" EXACT [] +xref: Wikipedia:Protein_metabolism +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044238 ! primary metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0019539 +name: hydroxymate-containing siderophore biosynthetic process +namespace: biological_process +alt_id: GO:0031197 +alt_id: GO:0031198 +def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. Hydroxamate is one of the three major chemical groups incorporated into siderophore structures with catechol and a-hydroxycarboxylate, each having a high selectivity for iron(3+)." [PMID:20376388] +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0019540 +name: catechol-containing siderophore biosynthetic process +namespace: biological_process +alt_id: GO:0031189 +alt_id: GO:0031190 +def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. Catechol is one of the three major chemical groups incorporated into siderophore structures with hydroxamate and a-hydroxycarboxylate, each having a high selectivity for iron(3+)." [PMID:20376388] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:0019541 +name: propionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732] +synonym: "propanoate metabolic process" EXACT [] +synonym: "propanoate metabolism" EXACT [] +synonym: "propionate metabolism" EXACT [] +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0019542 +name: propionate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators] +synonym: "propionate anabolism" EXACT [] +synonym: "propionate biosynthesis" EXACT [] +synonym: "propionate formation" EXACT [] +synonym: "propionate synthesis" EXACT [] +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0051790 ! short-chain fatty acid biosynthetic process + +[Term] +id: GO:0019543 +name: propionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators] +synonym: "propionate breakdown" EXACT [] +synonym: "propionate catabolism" EXACT [] +synonym: "propionate degradation" EXACT [] +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0019626 ! short-chain fatty acid catabolic process + +[Term] +id: GO:0019544 +name: arginine catabolic process to glutamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators] +synonym: "arginine breakdown to glutamate" EXACT [] +synonym: "arginine degradation to glutamate" EXACT [] +xref: MetaCyc:ARG-GLU-PWY +xref: MetaCyc:ARGASEDEG-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006536 ! glutamate metabolic process + +[Term] +id: GO:0019545 +name: arginine catabolic process to succinate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators] +synonym: "arginine breakdown to succinate" EXACT [] +synonym: "arginine degradation to succinate" EXACT [] +xref: MetaCyc:ARGDEG-III-PWY +xref: MetaCyc:ARGDEG-IV-PWY +xref: MetaCyc:ARGDEG-V-PWY +xref: MetaCyc:AST-PWY +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0019546 +name: arginine deiminase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY] +xref: MetaCyc:ARGDEGRAD-PWY +is_a: GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0019547 +name: arginine catabolic process to ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators] +synonym: "arginine breakdown to ornithine" EXACT [] +synonym: "arginine degradation to ornithine" EXACT [] +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0019548 +name: arginine catabolic process to spermine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators] +synonym: "arginine breakdown to spermine" EXACT [] +synonym: "arginine degradation to spermine" EXACT [] +xref: MetaCyc:ARGSPECAT-PWY +is_a: GO:0006527 ! arginine catabolic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0019549 +name: glutamate catabolic process to succinate via succinate semialdehyde +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321] +comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. +synonym: "glutamate breakdown to succinate" BROAD [] +synonym: "glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity" EXACT [] +synonym: "glutamate degradation to succinate" BROAD [] +xref: MetaCyc:PWY-4321 +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0006540 ! glutamate decarboxylation to succinate + +[Term] +id: GO:0019550 +name: glutamate catabolic process to aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators] +synonym: "glutamate breakdown to aspartate" EXACT [] +synonym: "glutamate degradation to aspartate" EXACT [] +xref: MetaCyc:GLUTDEG-PWY +is_a: GO:0006531 ! aspartate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019551 +name: glutamate catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators] +synonym: "glutamate breakdown to 2-oxoglutarate" EXACT [] +synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "glutamate catabolism to 2-ketoglutarate" EXACT [] +synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT [] +synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT [] +synonym: "glutamate degradation to 2-oxoglutarate" EXACT [] +xref: MetaCyc:GLUTAMATE-DEG1-PWY +xref: MetaCyc:PWY-5766 +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006106 ! fumarate metabolic process +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019552 +name: glutamate catabolic process via 2-hydroxyglutarate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY] +synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT [] +xref: MetaCyc:P162-PWY +is_a: GO:0019670 ! anaerobic glutamate catabolic process + +[Term] +id: GO:0019553 +name: glutamate catabolic process via L-citramalate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators] +synonym: "glutamate breakdown via L-citramalate" EXACT [] +synonym: "glutamate degradation via L-citramalate" EXACT [] +xref: MetaCyc:GLUDEG-II-PWY +is_a: GO:0006538 ! glutamate catabolic process + +[Term] +id: GO:0019554 +name: glutamate catabolic process to oxaloacetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators] +synonym: "glutamate breakdown to oxaloacetate" EXACT [] +synonym: "glutamate degradation to oxaloacetate" EXACT [] +is_a: GO:0006107 ! oxaloacetate metabolic process +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019555 +name: glutamate catabolic process to ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators] +synonym: "glutamate breakdown to ornithine" EXACT [] +synonym: "glutamate degradation to ornithine" EXACT [] +xref: MetaCyc:GLUTORN-PWY +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0019556 +name: histidine catabolic process to glutamate and formamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators] +synonym: "histidine breakdown to glutamate and formamide" EXACT [] +synonym: "histidine degradation to glutamate and formamide" EXACT [] +xref: MetaCyc:HISDEG-PWY +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006548 ! histidine catabolic process +is_a: GO:0043606 ! formamide metabolic process + +[Term] +id: GO:0019557 +name: histidine catabolic process to glutamate and formate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators] +synonym: "histidine breakdown to glutamate and formate" EXACT [] +synonym: "histidine degradation to glutamate and formate" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006548 ! histidine catabolic process +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0019558 +name: histidine catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators] +synonym: "histidine breakdown to 2-oxoglutarate" EXACT [] +synonym: "histidine catabolic process to 2-ketoglutarate" EXACT [] +synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "histidine catabolism to 2-ketoglutarate" EXACT [] +synonym: "histidine catabolism to alpha-ketoglutarate" EXACT [] +synonym: "histidine catabolism to alpha-oxoglutarate" EXACT [] +synonym: "histidine degradation to 2-oxoglutarate" EXACT [] +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019559 +name: histidine catabolic process to imidazol-5-yl-lactate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators] +synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT [] +synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT [] +xref: MetaCyc:HISTDEG-PWY +is_a: GO:0006548 ! histidine catabolic process + +[Term] +id: GO:0019560 +name: histidine catabolic process to hydantoin-5-propionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators] +synonym: "histidine breakdown to hydantoin-5-propionate" EXACT [] +synonym: "histidine degradation to hydantoin-5-propionate" EXACT [] +xref: MetaCyc:HISHP-PWY +is_a: GO:0006548 ! histidine catabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0019561 +name: anaerobic phenylalanine oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY] +xref: MetaCyc:ANAPHENOXI-PWY +is_a: GO:0006559 ! L-phenylalanine catabolic process + +[Term] +id: GO:0019562 +name: obsolete L-phenylalanine catabolic process to phosphoenolpyruvate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] +comment: The reason for obsoletion is that there is no evidence that this is a real process. +synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT [] +synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT [] +xref: MetaCyc:PHENYLALANINE-DEG1-PWY +is_obsolete: true + +[Term] +id: GO:0019563 +name: glycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732] +synonym: "glycerol breakdown" EXACT [] +synonym: "glycerol catabolism" EXACT [] +synonym: "glycerol degradation" EXACT [] +xref: MetaCyc:PWY-4261 +xref: MetaCyc:PWY0-381 +is_a: GO:0006071 ! glycerol metabolic process +is_a: GO:0019405 ! alditol catabolic process + +[Term] +id: GO:0019564 +name: aerobic glycerol catabolic process +namespace: biological_process +alt_id: GO:0019565 +def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732] +synonym: "aerobic glycerol breakdown" EXACT [] +synonym: "aerobic glycerol catabolism" EXACT [] +synonym: "aerobic glycerol degradation" EXACT [] +synonym: "aerobic glycerol fermentation" RELATED [] +xref: MetaCyc:PWY0-381 +is_a: GO:0019563 ! glycerol catabolic process + +[Term] +id: GO:0019566 +name: arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732] +synonym: "arabinose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0019567 +name: arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai] +synonym: "arabinose anabolism" EXACT [] +synonym: "arabinose biosynthesis" EXACT [] +synonym: "arabinose formation" EXACT [] +synonym: "arabinose synthesis" EXACT [] +is_a: GO:0019322 ! pentose biosynthetic process +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0019568 +name: arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai] +synonym: "arabinose breakdown" EXACT [] +synonym: "arabinose catabolism" EXACT [] +synonym: "arabinose degradation" EXACT [] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0019569 +name: L-arabinose catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators] +synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT [] +xref: MetaCyc:ARABCAT-PWY +is_a: GO:0019572 ! L-arabinose catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019570 +name: L-arabinose catabolic process to 2-oxoglutarate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators] +synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT [] +synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT [] +synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT [] +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0019572 ! L-arabinose catabolic process + +[Term] +id: GO:0019571 +name: D-arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah] +synonym: "D-arabinose breakdown" EXACT [] +synonym: "D-arabinose catabolism" EXACT [] +synonym: "D-arabinose degradation" EXACT [] +is_a: GO:0019568 ! arabinose catabolic process +is_a: GO:0046372 ! D-arabinose metabolic process + +[Term] +id: GO:0019572 +name: L-arabinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [GOC:jsg, GOC:mah] +synonym: "L-arabinose breakdown" EXACT [] +synonym: "L-arabinose catabolism" EXACT [] +synonym: "L-arabinose degradation" EXACT [] +is_a: GO:0019568 ! arabinose catabolic process +is_a: GO:0046373 ! L-arabinose metabolic process + +[Term] +id: GO:0019573 +name: D-arabinose catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators] +synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT [] +synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT [] +xref: MetaCyc:DARABCAT-PWY +is_a: GO:0019571 ! D-arabinose catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019574 +name: sucrose catabolic process via 3'-ketosucrose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose." [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY] +synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT [] +synonym: "sucrose catabolic process to D-glucose" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] +synonym: "sucrose catabolic process, using glucoside 3-dehydrogenase" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] +synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT [] +synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT [] +xref: MetaCyc:SUCROSEUTIL2-PWY +is_a: GO:0005987 ! sucrose catabolic process +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0019575 +name: obsolete sucrose catabolic process, using beta-fructofuranosidase +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl] +comment: This term was made obsolete because beta-fructofuranosidase (also known as invertase) catalyzes the first step in multiple routes of sucrose catabolism. +synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT [] +synonym: "sucrose catabolic process, using beta-fructofuranosidase" EXACT [] +synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT [] +synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT [] +xref: MetaCyc:SUCUTIL-PWY +is_obsolete: true +consider: GO:0004564 +consider: GO:0036008 + +[Term] +id: GO:0019576 +name: aerobic fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai] +synonym: "aerobic fructose breakdown" EXACT [] +synonym: "aerobic fructose catabolism" EXACT [] +synonym: "aerobic fructose degradation" EXACT [] +is_a: GO:0006001 ! fructose catabolic process + +[Term] +id: GO:0019577 +name: aldaric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] +synonym: "aldaric acid metabolism" EXACT [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0019578 +name: aldaric acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] +synonym: "aldaric acid anabolism" EXACT [] +synonym: "aldaric acid biosynthesis" EXACT [] +synonym: "aldaric acid formation" EXACT [] +synonym: "aldaric acid synthesis" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0019579 +name: aldaric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] +synonym: "aldaric acid breakdown" EXACT [] +synonym: "aldaric acid catabolism" EXACT [] +synonym: "aldaric acid degradation" EXACT [] +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0019577 ! aldaric acid metabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0019580 +name: galactarate metabolic process +namespace: biological_process +alt_id: GO:0046393 +def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [GOC:pr, ISBN:0198506732] +synonym: "D-galactarate metabolic process" RELATED [] +synonym: "D-galactarate metabolism" RELATED [] +synonym: "galactarate metabolism" EXACT [] +synonym: "mucic acid metabolic process" EXACT [] +synonym: "mucic acid metabolism" EXACT [] +is_a: GO:0019577 ! aldaric acid metabolic process + +[Term] +id: GO:0019583 +name: galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai] +synonym: "galactonate metabolism" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process + +[Term] +id: GO:0019584 +name: galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai] +synonym: "galactonate breakdown" EXACT [] +synonym: "galactonate catabolism" EXACT [] +synonym: "galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019583 ! galactonate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0019585 +name: glucuronate metabolic process +namespace: biological_process +alt_id: GO:0019699 +def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732] +synonym: "glucuronate metabolism" EXACT [] +xref: Wikipedia:Glucuronic_acid +is_a: GO:0006063 ! uronic acid metabolic process + +[Term] +id: GO:0019586 +name: galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732] +synonym: "galacturonate metabolism" EXACT [] +is_a: GO:0006063 ! uronic acid metabolic process + +[Term] +id: GO:0019588 +name: anaerobic glycerol catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah] +synonym: "glycerol fermentation" EXACT [] +is_a: GO:0019563 ! glycerol catabolic process +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019589 +name: anaerobic glycerol catabolic process to propane-1,3-diol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY] +synonym: "glycerol fermentation to 1,3-propanediol" EXACT [] +synonym: "glycerol fermentation to propane-1,3-diol" EXACT [] +xref: MetaCyc:GOLPDLCAT-PWY +is_a: GO:0019588 ! anaerobic glycerol catabolic process +is_a: GO:0051143 ! propanediol metabolic process + +[Term] +id: GO:0019590 +name: L-arabitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] +synonym: "L-arabitol and xylitol degradation" BROAD [] +synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "L-arabitol utilization" RELATED [] +xref: MetaCyc:LARABITOLUTIL-PWY +is_a: GO:0051158 ! L-arabitol catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019592 +name: mannitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "mannitol breakdown" EXACT [] +synonym: "mannitol catabolism" EXACT [] +synonym: "mannitol degradation" EXACT [] +xref: MetaCyc:MANNIDEG-PWY +xref: MetaCyc:PWY-3861 +is_a: GO:0019407 ! hexitol catabolic process +is_a: GO:0019594 ! mannitol metabolic process + +[Term] +id: GO:0019593 +name: mannitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "mannitol anabolism" EXACT [] +synonym: "mannitol biosynthesis" EXACT [] +synonym: "mannitol formation" EXACT [] +synonym: "mannitol synthesis" EXACT [] +xref: MetaCyc:PWY-3881 +is_a: GO:0019406 ! hexitol biosynthetic process +is_a: GO:0019594 ! mannitol metabolic process + +[Term] +id: GO:0019594 +name: mannitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "mannitol metabolism" EXACT [] +is_a: GO:0006059 ! hexitol metabolic process + +[Term] +id: GO:0019595 +name: non-phosphorylated glucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai] +synonym: "non-phosphorylated glucose breakdown" EXACT [] +synonym: "non-phosphorylated glucose catabolism" EXACT [] +synonym: "non-phosphorylated glucose degradation" EXACT [] +xref: MetaCyc:NPGLUCAT-PWY +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0046430 ! non-phosphorylated glucose metabolic process + +[Term] +id: GO:0019596 +name: mandelate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators] +synonym: "mandelate breakdown" EXACT [] +synonym: "mandelate catabolism" EXACT [] +synonym: "mandelate degradation" EXACT [] +is_a: GO:0018924 ! mandelate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0019597 +name: (R)-mandelate catabolic process to benzoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] +synonym: "(R)-mandelate breakdown to benzoate" EXACT [] +synonym: "(R)-mandelate degradation to benzoate" EXACT [] +is_a: GO:0018874 ! benzoate metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019596 ! mandelate catabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0019598 +name: (R)-mandelate catabolic process to catechol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators] +synonym: "(R)-mandelate breakdown to catechol" EXACT [] +synonym: "(R)-mandelate degradation to catechol" EXACT [] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0019596 ! mandelate catabolic process + +[Term] +id: GO:0019599 +name: (R)-4-hydroxymandelate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai] +synonym: "(R)-4-hydroxymandelate breakdown" EXACT [] +synonym: "(R)-4-hydroxymandelate catabolism" EXACT [] +synonym: "(R)-4-hydroxymandelate degradation" EXACT [] +xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0019600 +name: toluene oxidation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah] +is_a: GO:0018970 ! toluene metabolic process + +[Term] +id: GO:0019601 +name: toluene oxidation via 2-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY] +xref: MetaCyc:TOLUENE-DEG-2-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019602 +name: toluene oxidation via 3-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY] +xref: MetaCyc:TOLUENE-DEG-3-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019603 +name: toluene oxidation via 4-hydroxytoluene +namespace: biological_process +def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY] +xref: MetaCyc:TOLUENE-DEG-4-OH-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019604 +name: toluene oxidation to catechol +namespace: biological_process +def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY] +xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY +xref: UM-BBD_pathwayID:tol +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019605 +name: butyrate metabolic process +namespace: biological_process +alt_id: GO:0043437 +def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732] +synonym: "butanoic acid metabolic process" EXACT [] +synonym: "butanoic acid metabolism" EXACT [] +synonym: "butyrate metabolism" EXACT [] +synonym: "butyric acid metabolic process" EXACT [] +synonym: "butyric acid metabolism" EXACT [] +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0019606 +name: 2-oxobutyrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732] +synonym: "2-oxobutyrate breakdown" EXACT [] +synonym: "2-oxobutyrate catabolism" EXACT [] +synonym: "2-oxobutyrate degradation" EXACT [] +synonym: "alpha-ketobutyrate catabolic process" EXACT [] +synonym: "alpha-ketobutyrate catabolism" EXACT [] +xref: MetaCyc:2OXOBUTYRATECAT-PWY +is_a: GO:0019626 ! short-chain fatty acid catabolic process +is_a: GO:0046361 ! 2-oxobutyrate metabolic process + +[Term] +id: GO:0019607 +name: phenylethylamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine breakdown" EXACT [] +synonym: "phenylethylamine catabolism" EXACT [] +synonym: "phenylethylamine degradation" EXACT [] +xref: MetaCyc:2PHENDEG-PWY +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:0042443 ! phenylethylamine metabolic process +is_a: GO:1901161 ! primary amino compound catabolic process + +[Term] +id: GO:0019608 +name: nicotine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +synonym: "nicotine breakdown" EXACT [] +synonym: "nicotine catabolism" EXACT [] +synonym: "nicotine degradation" EXACT [] +xref: MetaCyc:P181-PWY +xref: UM-BBD_pathwayID:nic +is_a: GO:0009056 ! catabolic process +is_a: GO:0018933 ! nicotine metabolic process + +[Term] +id: GO:0019609 +name: 3-hydroxyphenylacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] +synonym: "3-hydroxyphenylacetate metabolism" EXACT [] +synonym: "3HPA metabolic process" EXACT [] +synonym: "3HPA metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019610 +name: 3-hydroxyphenylacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] +synonym: "3-hydroxyphenylacetate breakdown" EXACT [] +synonym: "3-hydroxyphenylacetate catabolism" EXACT [] +synonym: "3-hydroxyphenylacetate degradation" EXACT [] +xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0019611 +name: 4-toluenecarboxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +synonym: "4-toluenecarboxylate metabolism" EXACT [] +synonym: "p-toluate metabolic process" EXACT [] +synonym: "p-toluate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0019612 +name: 4-toluenecarboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +synonym: "4-toluenecarboxylate breakdown" EXACT [] +synonym: "4-toluenecarboxylate catabolism" EXACT [] +synonym: "4-toluenecarboxylate degradation" EXACT [] +synonym: "p-toluate catabolic process" EXACT [] +synonym: "p-toluate catabolism" EXACT [] +xref: MetaCyc:4TOLCARBDEG-PWY +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019614 +name: catechol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] +synonym: "catechol breakdown" RELATED [] +synonym: "catechol catabolic process" RELATED [] +synonym: "catechol catabolism" RELATED [] +synonym: "catechol degradation" RELATED [] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process + +[Term] +id: GO:0019615 +name: catechol catabolic process, ortho-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/] +synonym: "catechol breakdown, ortho-cleavage" EXACT [] +synonym: "catechol degradation, ortho-cleavage" EXACT [] +xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0042952 ! beta-ketoadipate pathway + +[Term] +id: GO:0019616 +name: catechol catabolic process, meta-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/] +synonym: "catechol breakdown, meta-cleavage" EXACT [] +synonym: "catechol degradation, meta-cleavage" EXACT [] +xref: MetaCyc:P183-PWY +is_a: GO:0019614 ! catechol-containing compound catabolic process + +[Term] +id: GO:0019617 +name: protocatechuate catabolic process, meta-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY] +synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED [] +synonym: "protocatechuate breakdown, meta-cleavage" EXACT [] +synonym: "protocatechuate catabolic process to oxaloacetate and pyruvate" EXACT [] +synonym: "protocatechuate degradation, meta-cleavage" EXACT [] +xref: MetaCyc:P184-PWY +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0006107 ! oxaloacetate metabolic process +is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process + +[Term] +id: GO:0019618 +name: protocatechuate catabolic process, ortho-cleavage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY] +synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT [] +synonym: "protocatechuate breakdown, ortho-cleavage" EXACT [] +synonym: "protocatechuate catabolic process to beta-ketoadipate" EXACT [] +synonym: "protocatechuate degradation, ortho-cleavage" EXACT [] +xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY +is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0019619 +name: 3,4-dihydroxybenzoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." [GOC:ai] +synonym: "protocatechuate breakdown" EXACT [] +synonym: "protocatechuate catabolic process" EXACT [] +synonym: "protocatechuate catabolism" EXACT [] +synonym: "protocatechuate degradation" EXACT [] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0019620 +name: aerobic benzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai] +synonym: "aerobic benzoate metabolism" EXACT [] +is_a: GO:0018874 ! benzoate metabolic process + +[Term] +id: GO:0019621 +name: creatinine catabolic process to formate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators] +synonym: "creatinine breakdown to formate" EXACT [] +synonym: "creatinine degradation to formate" EXACT [] +xref: MetaCyc:CRNFORCAT-PWY +is_a: GO:0006602 ! creatinine catabolic process +is_a: GO:0015942 ! formate metabolic process + +[Term] +id: GO:0019622 +name: 3-(3-hydroxy)phenylpropionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] +synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT [] +synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT [] +synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT [] +xref: MetaCyc:HCAMHPDEG-PWY +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019623 +name: atrazine catabolic process to urea +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl] +synonym: "atrazine breakdown to urea" EXACT [] +synonym: "atrazine degradation to urea" EXACT [] +is_a: GO:0019381 ! atrazine catabolic process +is_a: GO:0019627 ! urea metabolic process + +[Term] +id: GO:0019624 +name: atrazine catabolic process to isopropylamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl] +synonym: "atrazine breakdown to isopropylamine" EXACT [] +synonym: "atrazine degradation to isopropylamine" EXACT [] +is_a: GO:0019381 ! atrazine catabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0019625 +name: atrazine catabolic process to cyanuric acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl] +synonym: "atrazine breakdown to cyanuric acid" EXACT [] +synonym: "atrazine degradation to cyanuric acid" EXACT [] +xref: MetaCyc:P141-PWY +is_a: GO:0019381 ! atrazine catabolic process +is_a: GO:0042199 ! cyanuric acid metabolic process + +[Term] +id: GO:0019626 +name: short-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6." [ISBN:0198506732] +synonym: "short-chain fatty acid breakdown" EXACT [] +synonym: "short-chain fatty acid catabolism" EXACT [] +synonym: "short-chain fatty acid degradation" EXACT [] +xref: MetaCyc:ACETOACETATE-DEG-PWY +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0019627 +name: urea metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732] +synonym: "urea metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0071941 ! nitrogen cycle metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0019628 +name: urate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732] +synonym: "urate breakdown" EXACT [] +synonym: "urate catabolism" EXACT [] +synonym: "urate degradation" EXACT [] +synonym: "uric acid catabolic process" EXACT [] +xref: MetaCyc:P165-PWY +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:0046415 ! urate metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0019629 +name: propionate catabolic process, 2-methylcitrate cycle +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators] +synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT [] +synonym: "propionate degradation, 2-methylcitrate cycle" EXACT [] +is_a: GO:0019543 ! propionate catabolic process + +[Term] +id: GO:0019630 +name: quinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732] +synonym: "quinate metabolism" EXACT [] +synonym: "quinic acid metabolic process" EXACT [] +synonym: "quinic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019631 +name: quinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl] +synonym: "quinate breakdown" EXACT [] +synonym: "quinate catabolism" EXACT [] +synonym: "quinate degradation" EXACT [] +synonym: "quinic acid catabolic process" EXACT [] +synonym: "quinic acid catabolism" EXACT [] +xref: MetaCyc:QUINATEDEG-PWY +is_a: GO:0019630 ! quinate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0019632 +name: shikimate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:sm, ISBN:0198547684] +synonym: "shikimate metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0019633 +name: shikimate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [GOC:go_curators] +synonym: "shikimate breakdown" EXACT [] +synonym: "shikimate catabolism" EXACT [] +synonym: "shikimate degradation" EXACT [] +xref: MetaCyc:SHIKIMATEDEG-PWY +is_a: GO:0019632 ! shikimate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0019634 +name: organic phosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544] +synonym: "organophosphonate metabolic process" RELATED [] +synonym: "phosphonate metabolism" EXACT [] +is_a: GO:0019637 ! organophosphate metabolic process + +[Term] +id: GO:0019635 +name: 2-aminoethylphosphonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai] +synonym: "2-aminoethylphosphonate breakdown" EXACT [] +synonym: "2-aminoethylphosphonate catabolism" EXACT [] +synonym: "2-aminoethylphosphonate degradation" EXACT [] +synonym: "2-phosphonoethylamine catabolic process" EXACT [] +synonym: "2-phosphonoethylamine catabolism" EXACT [] +synonym: "ciliatine catabolic process" EXACT [] +synonym: "ciliatine catabolism" EXACT [] +xref: MetaCyc:PHOSPHONOTASE-PWY +is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process +is_a: GO:1901161 ! primary amino compound catabolic process + +[Term] +id: GO:0019636 +name: phosphonoacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY] +synonym: "phosphonoacetate metabolism" EXACT [] +xref: MetaCyc:P483-PWY +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0019637 +name: organophosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] +synonym: "organophosphate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0019638 +name: 6-hydroxycineole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +synonym: "6-endo-hydroxycineole metabolic process" EXACT [] +synonym: "6-endo-hydroxycineole metabolism" EXACT [] +synonym: "6-hydroxycineole metabolism" EXACT [] +synonym: "hydroxycineol metabolic process" EXACT [] +synonym: "hydroxycineol metabolism" EXACT [] +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0097176 ! epoxide metabolic process + +[Term] +id: GO:0019639 +name: 6-hydroxycineole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +synonym: "6-endo-hydroxycineole catabolic process" EXACT [] +synonym: "6-endo-hydroxycineole catabolism" EXACT [] +synonym: "6-hydroxycineole breakdown" EXACT [] +synonym: "6-hydroxycineole catabolism" EXACT [] +synonym: "6-hydroxycineole degradation" EXACT [] +synonym: "hydroxycineol catabolic process" EXACT [] +synonym: "hydroxycineol catabolism" EXACT [] +xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY +is_a: GO:0016100 ! monoterpenoid catabolic process +is_a: GO:0019638 ! 6-hydroxycineole metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0019640 +name: glucuronate catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators] +synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT [] +synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT [] +is_a: GO:0006064 ! glucuronate catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019643 +name: reductive tricarboxylic acid cycle +namespace: biological_process +alt_id: GO:0019644 +def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028] +synonym: "reductive carboxylate cycle" EXACT [] +synonym: "reductive carboxylic acid cycle" EXACT [] +synonym: "reductive citric acid pathway" EXACT [] +synonym: "reductive Kreb's cycle" EXACT [] +synonym: "reductive TCA cycle" EXACT [] +xref: MetaCyc:P23-PWY +xref: MetaCyc:REDCITCYC +is_a: GO:0006099 ! tricarboxylic acid cycle +is_a: GO:0015977 ! carbon fixation + +[Term] +id: GO:0019645 +name: anaerobic electron transport chain +namespace: biological_process +def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0009061 ! anaerobic respiration + +[Term] +id: GO:0019646 +name: aerobic electron transport chain +namespace: biological_process +alt_id: GO:0006136 +alt_id: GO:0006137 +alt_id: GO:0006138 +def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] +synonym: "NADH-O2 electron transport" NARROW [] +synonym: "succinate-O2 electron transport" NARROW [] +synonym: "ubiquinone-8-O2 electron transport" NARROW [] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0019647 +name: formaldehyde assimilation via ribulose monophosphate cycle +namespace: biological_process +def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861] +synonym: "formaldehyde assimilation via RuMP cycle" EXACT [] +synonym: "ribulose monophosphate cycle" BROAD [] +xref: MetaCyc:PWY-1861 +is_a: GO:0019649 ! formaldehyde assimilation + +[Term] +id: GO:0019648 +name: formaldehyde assimilation via xylulose monophosphate cycle +namespace: biological_process +def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY] +synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT [] +synonym: "formaldehyde fixation cycle" EXACT [] +xref: MetaCyc:P185-PWY +is_a: GO:0019649 ! formaldehyde assimilation +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process + +[Term] +id: GO:0019649 +name: formaldehyde assimilation +namespace: biological_process +def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai] +is_a: GO:0046292 ! formaldehyde metabolic process + +[Term] +id: GO:0019650 +name: glycolytic fermentation to butanediol +namespace: biological_process +alt_id: GO:0030646 +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [GOC:dph, GOC:nr, ISBN:0198506732] +synonym: "butanediol fermentation" EXACT [] +synonym: "glucose catabolic process to butanediol" EXACT [GOC:dph] +synonym: "glucose fermentation to butanediol" EXACT [] +xref: MetaCyc:P125-PWY +xref: Wikipedia:Butanediol_fermentation +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019651 +name: citrate catabolic process to diacetyl +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] +synonym: "citrate fermentation to diacetyl" EXACT [] +synonym: "diacetyl fermentation" EXACT [] +is_a: GO:0006101 ! citrate metabolic process +is_a: GO:0019662 ! non-glycolytic fermentation +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0072352 ! tricarboxylic acid catabolic process + +[Term] +id: GO:0019652 +name: lactate fermentation to propionate and acetate +namespace: biological_process +def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY] +synonym: "acrylate pathway" EXACT [] +synonym: "nonrandomizing pathway" EXACT [] +synonym: "propionate fermentation" EXACT [] +xref: MetaCyc:PROPFERM-PWY +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019653 +name: anaerobic purine nucleobase catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP." [GOC:mah] +synonym: "anaerobic purine base catabolic process" EXACT [GOC:go_curators] +synonym: "anaerobic purine base catabolism" EXACT [] +synonym: "anaerobic purine catabolic process" RELATED [] +synonym: "purine base fermentation" EXACT [] +synonym: "purine fermentation" RELATED [] +xref: MetaCyc:P164-PWY +xref: MetaCyc:PWY-5044 +xref: MetaCyc:PWY-5497 +is_a: GO:0006145 ! purine nucleobase catabolic process +is_a: GO:0019666 ! nitrogenous compound fermentation + +[Term] +id: GO:0019654 +name: acetate fermentation +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [GOC:jl, MetaCyc:P142-PWY] +xref: MetaCyc:P142-PWY +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019655 +name: glycolytic fermentation to ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [GOC:dph, GOC:nr, ISBN:0716720094] +synonym: "alcoholic fermentation" RELATED [ISBN:0716720094] +synonym: "ethanol fermentation" EXACT [] +synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph] +synonym: "glucose fermentation to ethanol" EXACT [] +xref: Wikipedia:Ethanol_fermentation +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019656 +name: glucose catabolic process to D-lactate and ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY] +synonym: "glucose fermentation to D-lactate and ethanol" EXACT [] +synonym: "heterofermentation" EXACT [] +synonym: "heterofermentative lactate fermentation" EXACT [] +synonym: "heterofermentative pathway" EXACT [] +synonym: "heterolactate fermentation" EXACT [] +synonym: "heterolactic fermentation" EXACT [] +xref: MetaCyc:P122-PWY +is_a: GO:0019659 ! glucose catabolic process to lactate +is_a: GO:0019662 ! non-glycolytic fermentation +is_a: GO:1902707 ! hexose catabolic process to ethanol + +[Term] +id: GO:0019657 +name: glycolytic fermentation to propionate +namespace: biological_process +def: "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [GOC:dph, GOC:nr, MetaCyc:P108-PWY] +synonym: "succinate-propionate fermentation" EXACT [] +xref: MetaCyc:P108-PWY +is_a: GO:0006105 ! succinate metabolic process +is_a: GO:0019541 ! propionate metabolic process +is_a: GO:0019660 ! glycolytic fermentation +is_a: GO:0042867 ! pyruvate catabolic process + +[Term] +id: GO:0019658 +name: glucose fermentation to lactate and acetate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY] +synonym: "bifidum pathway" EXACT [] +synonym: "glucose catabolic process to lactate and acetate" BROAD [] +xref: MetaCyc:P124-PWY +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019659 +name: glucose catabolic process to lactate +namespace: biological_process +def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] +synonym: "glucose fermentation to lactate" EXACT [] +synonym: "lactate fermentation" EXACT [] +xref: Wikipedia:Lactic_acid_fermentation +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019660 +name: glycolytic fermentation +namespace: biological_process +def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators] +xref: MetaCyc:Pyruvate-Degredation +is_a: GO:0006113 ! fermentation +is_a: GO:0046034 ! ATP metabolic process + +[Term] +id: GO:0019661 +name: glucose catabolic process to lactate via pyruvate +namespace: biological_process +def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] +synonym: "glucose fermentation to lactate via pyruvate" EXACT [] +synonym: "homofermentation" EXACT [] +synonym: "homofermentative lactate fermentation" EXACT [] +synonym: "homofermentative pathway" EXACT [] +synonym: "homolactate fermentation" EXACT [] +synonym: "homolactic fermentation" EXACT [ISBN:0716720094] +xref: MetaCyc:ANAEROFRUCAT-PWY +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019659 ! glucose catabolic process to lactate +is_a: GO:0019660 ! glycolytic fermentation +is_a: GO:0019674 ! NAD metabolic process + +[Term] +id: GO:0019662 +name: non-glycolytic fermentation +namespace: biological_process +def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0019664 +name: mixed acid fermentation +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [ISBN:0716720094, MetaCyc:FERMENTATION-PWY] +synonym: "glucose catabolic process to mixed acids" BROAD [] +synonym: "glucose fermentation to mixed acids" EXACT [] +xref: Wikipedia:Mixed_acid_fermentation +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0019665 +name: anaerobic amino acid catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] +synonym: "amino acid fermentation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0019666 ! nitrogenous compound fermentation + +[Term] +id: GO:0019666 +name: nitrogenous compound fermentation +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah] +synonym: "nitrogenous compound catabolic process" BROAD [] +is_a: GO:0006113 ! fermentation +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0019667 +name: anaerobic L-alanine catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl] +synonym: "L-alanine fermentation" EXACT [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019668 +name: anaerobic catabolism of pairs of amino acids +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081] +synonym: "cofermentation of pairs of amino acids" EXACT [] +synonym: "Stickland reaction" NARROW [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019669 +name: anaerobic glycine catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl] +synonym: "glycine fermentation" EXACT [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019670 +name: anaerobic glutamate catabolic process +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl] +synonym: "glutamate fermentation" EXACT [] +is_a: GO:0019665 ! anaerobic amino acid catabolic process + +[Term] +id: GO:0019671 +name: glutamate catabolic process via mesaconate and citramalate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY] +synonym: "glutamate fermentation via mesaconate and citramalate" EXACT [] +xref: MetaCyc:GLUDEG-II-PWY +xref: MetaCyc:PWY-5087 +xref: MetaCyc:PWY-5088 +is_a: GO:0019670 ! anaerobic glutamate catabolic process + +[Term] +id: GO:0019672 +name: ethanol-acetate fermentation to butyrate and caproate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] +is_a: GO:0019662 ! non-glycolytic fermentation + +[Term] +id: GO:0019673 +name: GDP-mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-mannose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0019674 +name: NAD metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +synonym: "NAD (oxidized) metabolic process" EXACT [] +synonym: "NAD (oxidized) metabolism" EXACT [] +synonym: "NAD metabolism" EXACT [] +synonym: "NAD phosphorylation and dephosphorylation" NARROW [] +synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide metabolism" EXACT [] +synonym: "oxidized NAD metabolic process" EXACT [] +synonym: "oxidized NAD metabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0019675 +name: obsolete NAD phosphorylation and dephosphorylation +namespace: biological_process +def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] +comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist. +synonym: "NAD phosphorylation and dephosphorylation" EXACT [] +synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT [] +is_obsolete: true +consider: GO:0006739 +consider: GO:0019674 + +[Term] +id: GO:0019676 +name: ammonia assimilation cycle +namespace: biological_process +def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY] +synonym: "glutamate metabolic process via glutamine and ammonia" EXACT [] +synonym: "glutamate metabolism via glutamine and ammonia" EXACT [] +xref: MetaCyc:AMMASSIM-PWY +xref: MetaCyc:PWY-3282 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0019677 +name: NAD catabolic process +namespace: biological_process +alt_id: GO:0006737 +def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] +synonym: "NAD (oxidized) catabolic process" EXACT [] +synonym: "NAD (oxidized) catabolism" EXACT [] +synonym: "NAD (reduced) catabolic process" EXACT [] +synonym: "NAD (reduced) catabolism" EXACT [] +synonym: "NAD breakdown" EXACT [] +synonym: "NAD catabolism" EXACT [] +synonym: "NAD degradation" EXACT [] +synonym: "NADH catabolic process" EXACT [] +synonym: "NADH catabolism" EXACT [] +synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "nicotinamide adenine dinucleotide catabolism" EXACT [] +synonym: "oxidized NAD catabolic process" EXACT [] +synonym: "oxidized NAD catabolism" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT [] +synonym: "reduced NAD catabolic process" EXACT [] +synonym: "reduced NAD catabolism" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT [] +is_a: GO:0019364 ! pyridine nucleotide catabolic process +is_a: GO:0046496 ! nicotinamide nucleotide metabolic process + +[Term] +id: GO:0019678 +name: propionate metabolic process, methylmalonyl pathway +namespace: biological_process +def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators] +synonym: "propionate metabolism, methylmalonyl pathway" EXACT [] +xref: MetaCyc:PROPIONMET-PWY +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0019679 +name: propionate metabolic process, methylcitrate cycle +namespace: biological_process +def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators] +synonym: "propionate metabolism, methylcitrate cycle" EXACT [] +xref: MetaCyc:PWY0-42 +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0019680 +name: L-methylmalonyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "L-methylmalonyl-CoA anabolism" EXACT [] +synonym: "L-methylmalonyl-CoA biosynthesis" EXACT [] +synonym: "L-methylmalonyl-CoA formation" EXACT [] +synonym: "L-methylmalonyl-CoA synthesis" EXACT [] +xref: MetaCyc:PWY0-43 +is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process + +[Term] +id: GO:0019681 +name: acetyl-CoA assimilation pathway +namespace: biological_process +def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY] +synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] +synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] +is_a: GO:0006103 ! 2-oxoglutarate metabolic process +is_a: GO:0046356 ! acetyl-CoA catabolic process + +[Term] +id: GO:0019682 +name: glyceraldehyde-3-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732] +synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT [] +synonym: "glyceraldehyde 3-phosphate metabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0019683 +name: glyceraldehyde-3-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732] +synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT [] +synonym: "glyceraldehyde 3-phosphate catabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate breakdown" EXACT [] +synonym: "glyceraldehyde-3-phosphate catabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate degradation" EXACT [] +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0019684 +name: photosynthesis, light reaction +namespace: biological_process +def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org] +synonym: "photolysis" RELATED [] +xref: MetaCyc:PWY-101 +xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis +is_a: GO:0006091 ! generation of precursor metabolites and energy +relationship: part_of GO:0015979 ! photosynthesis + +[Term] +id: GO:0019685 +name: photosynthesis, dark reaction +namespace: biological_process +def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952] +is_a: GO:0016051 ! carbohydrate biosynthetic process +relationship: part_of GO:0015979 ! photosynthesis + +[Term] +id: GO:0019686 +name: purine nucleoside interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0015949 ! nucleobase-containing small molecule interconversion +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0019687 +name: pyruvate biosynthetic process from acetate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators] +synonym: "pyruvate anabolism from acetate" EXACT [] +synonym: "pyruvate formation from acetate" EXACT [] +synonym: "pyruvate synthesis from acetate" EXACT [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0042866 ! pyruvate biosynthetic process + +[Term] +id: GO:0019688 +name: purine deoxyribonucleoside interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0019686 ! purine nucleoside interconversion +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0019689 +name: pyrimidine nucleoside interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0015949 ! nucleobase-containing small molecule interconversion + +[Term] +id: GO:0019690 +name: pyrimidine deoxyribonucleoside interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] +is_a: GO:0019689 ! pyrimidine nucleoside interconversion +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0019692 +name: deoxyribose phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] +synonym: "deoxyribose phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0019693 +name: ribose phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] +synonym: "ribose phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0019694 +name: alkanesulfonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] +synonym: "alkanesulfonate metabolism" EXACT [] +synonym: "alkanesulphonate metabolic process" EXACT [] +synonym: "alkanesulphonate metabolism" EXACT [] +xref: MetaCyc:ALKANEMONOX-PWY +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0019695 +name: choline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +synonym: "choline metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process +is_a: GO:0097164 ! ammonium ion metabolic process + +[Term] +id: GO:0019696 +name: toluene oxidation via toluene-cis-1,2-dihydrodiol +namespace: biological_process +def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY] +xref: MetaCyc:TOLUENE-DEG-DIOL-PWY +is_a: GO:0019600 ! toluene oxidation + +[Term] +id: GO:0019697 +name: L-xylitol catabolic process to xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] +synonym: "L-arabitol and xylitol degradation" BROAD [] +synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT [] +synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT [] +synonym: "L-xylitol utilization" RELATED [] +xref: MetaCyc:LARABITOLUTIL-PWY +is_a: GO:0051160 ! L-xylitol catabolic process +is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process + +[Term] +id: GO:0019698 +name: D-galacturonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-galacturonate breakdown" EXACT [] +synonym: "D-galacturonate catabolism" EXACT [] +synonym: "D-galacturonate degradation" EXACT [] +xref: MetaCyc:GALACTUROCAT-PWY +is_a: GO:0046365 ! monosaccharide catabolic process +is_a: GO:0046396 ! D-galacturonate metabolic process +is_a: GO:0046397 ! galacturonate catabolic process + +[Term] +id: GO:0019700 +name: organic phosphonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] +synonym: "organophosphonate catabolic process" RELATED [] +synonym: "phosphonate breakdown" EXACT [] +synonym: "phosphonate catabolism" EXACT [] +synonym: "phosphonate degradation" EXACT [] +is_a: GO:0019634 ! organic phosphonate metabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0019701 +name: peptidyl-arginine N5-methylation +namespace: biological_process +def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305] +synonym: "peptidyl-arginine delta-N-methylation" EXACT [] +xref: RESID:AA0305 +is_a: GO:0035246 ! peptidyl-arginine N-methylation + +[Term] +id: GO:0019702 +name: protein-arginine N5-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine." [EC:2.1.1.322, PMID:9873020] +comment: This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. +synonym: "protein-arginine delta-N-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)" RELATED [EC:2.1.1.322] +synonym: "type IV PRMT activity" EXACT [] +synonym: "type IV protein arginine methyltransferase activity" EXACT [] +xref: EC:2.1.1.322 +xref: RHEA:48116 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0019703 +name: coenzyme A-peptidyl-cysteine covalent linking +namespace: biological_process +def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306] +xref: RESID:AA0306 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019704 +name: peptidyl-L-cysteine S-myristoylation +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307] +synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0307 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018377 ! protein myristoylation + +[Term] +id: GO:0019705 +name: protein-cysteine S-myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]." [GOC:ai, PMID:22247542, RHEA:59736] +xref: RHEA:59736 +is_a: GO:0019107 ! myristoyltransferase activity +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0019706 +name: protein-cysteine S-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]." [GOC:ai, GOC:pr, RHEA:36683] +synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED [] +xref: EC:2.3.1.225 +xref: Reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer" +xref: Reactome:R-HSA-9021072 "ZDHHC7, ZDHHC21 palmitoylate ESR1" +xref: Reactome:R-HSA-9647982 "S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated" +xref: RHEA:36683 +is_a: GO:0016409 ! palmitoyltransferase activity +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0019707 +name: protein-cysteine S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai, RHEA:63372] +xref: RHEA:63372 +is_a: GO:0016417 ! S-acyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0019708 +name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine +namespace: biological_process +def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309] +synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0309 +is_a: GO:0006501 ! C-terminal protein lipidation +is_a: GO:0008203 ! cholesterol metabolic process +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process + +[Term] +id: GO:0019709 +name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide +namespace: biological_process +def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] +synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] +xref: RESID:AA0310 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0019710 +name: peptidyl-asparagine methylation +namespace: biological_process +alt_id: GO:0018018 +def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311] +xref: RESID:AA0070 +xref: RESID:AA0311 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0019711 +name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators] +synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT [] +synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0019712 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid +namespace: biological_process +def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072] +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT [] +xref: RESID:AA0072 +is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine + +[Term] +id: GO:0019713 +name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine +namespace: biological_process +def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072] +synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT [] +synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT [] +xref: RESID:AA0072 +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine +is_a: GO:0019714 ! peptidyl-glutamine esterification + +[Term] +id: GO:0019714 +name: peptidyl-glutamine esterification +namespace: biological_process +def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah] +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0019715 +name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid +namespace: biological_process +def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027] +comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. +xref: RESID:AA0027 +is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation + +[Term] +id: GO:0019716 +name: N-terminal peptidyl-alanine monomethylation +namespace: biological_process +def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061] +xref: RESID:AA0061 +is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation + +[Term] +id: GO:0019717 +name: obsolete synaptosome +namespace: cellular_component +def: "OBSOLETE. Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732] +comment: This term was made obsolete because it refers to a result of cell homogenization and not a bona fide cellular component. +synonym: "synaptosome" EXACT [] +xref: Wikipedia:Synaptosome +is_obsolete: true +consider: GO:0043005 + +[Term] +id: GO:0019718 +name: obsolete rough microsome +namespace: cellular_component +def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "rough microsome" EXACT [] +is_obsolete: true +consider: GO:0005791 + +[Term] +id: GO:0019719 +name: obsolete smooth microsome +namespace: cellular_component +def: "OBSOLETE. Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "smooth microsome" EXACT [] +is_obsolete: true +consider: GO:0005790 + +[Term] +id: GO:0019720 +name: Mo-molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] +synonym: "Mo-molybdopterin cofactor metabolism" EXACT [] +synonym: "Moco metabolic process" BROAD [] +synonym: "Moco metabolism" BROAD [] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0019722 +name: calcium-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] +synonym: "calcium ion signaling" EXACT [] +synonym: "calcium signaling" EXACT [] +synonym: "calcium signalling" EXACT [] +synonym: "calcium-mediated signalling" EXACT [] +xref: Wikipedia:Calcium_signaling +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0019724 +name: B cell mediated immunity +namespace: biological_process +def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "B lymphocyte mediated immune effector process" EXACT [] +synonym: "B lymphocyte mediated immunity" EXACT [] +synonym: "B-cell mediated immune effector process" EXACT [] +synonym: "B-cell mediated immunity" EXACT [] +synonym: "B-lymphocyte mediated immune effector process" EXACT [] +synonym: "B-lymphocyte mediated immunity" EXACT [] +is_a: GO:0002449 ! lymphocyte mediated immunity +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0019725 +name: cellular homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_plant +is_a: GO:0009987 ! cellular process +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0019726 +name: mevaldate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20193] +synonym: "(R)-mevalonate:NADP+ oxidoreductase" RELATED [EC:1.1.1.33] +synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" RELATED [EC:1.1.1.33] +xref: EC:1.1.1.33 +xref: KEGG_REACTION:R02247 +xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN +xref: RHEA:20193 +is_a: GO:0004495 ! mevaldate reductase activity + +[Term] +id: GO:0019727 +name: mevaldate reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH." [EC:1.1.1.32, RHEA:13221] +xref: EC:1.1.1.32 +xref: KEGG_REACTION:R02246 +xref: MetaCyc:MEVALDATE-REDUCTASE-RXN +xref: RHEA:13221 +is_a: GO:0004495 ! mevaldate reductase activity + +[Term] +id: GO:0019728 +name: peptidyl-allysine oxidation to 2-aminoadipic acid +namespace: biological_process +def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122] +xref: RESID:AA0370 +is_a: GO:0018158 ! protein oxidation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0019729 +name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0189 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018199 ! peptidyl-glutamine modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019730 +name: antimicrobial humoral response +namespace: biological_process +alt_id: GO:0006960 +alt_id: GO:0019735 +def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0019731 +name: antibacterial humoral response +namespace: biological_process +alt_id: GO:0006961 +alt_id: GO:0019733 +def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0019730 ! antimicrobial humoral response +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0019732 +name: antifungal humoral response +namespace: biological_process +alt_id: GO:0006966 +alt_id: GO:0019734 +def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0019730 ! antimicrobial humoral response +is_a: GO:0050832 ! defense response to fungus + +[Term] +id: GO:0019736 +name: peptidyl-sarcosine incorporation +namespace: biological_process +def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063] +xref: RESID:AA0063 +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0019740 +name: nitrogen utilization +namespace: biological_process +def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0019741 +name: pentacyclic triterpenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] +synonym: "pentacyclic triterpenoid breakdown" EXACT [] +synonym: "pentacyclic triterpenoid catabolism" EXACT [] +synonym: "pentacyclic triterpenoid degradation" EXACT [] +is_a: GO:0016105 ! triterpenoid catabolic process +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0019742 +name: pentacyclic triterpenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] +synonym: "pentacyclic triterpenoid metabolism" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0019743 +name: hopanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +synonym: "hopanoid breakdown" EXACT [] +synonym: "hopanoid catabolism" EXACT [] +synonym: "hopanoid degradation" EXACT [] +is_a: GO:0016105 ! triterpenoid catabolic process +is_a: GO:0019744 ! hopanoid metabolic process + +[Term] +id: GO:0019744 +name: hopanoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +synonym: "hopanoid metabolism" EXACT [] +is_a: GO:0006722 ! triterpenoid metabolic process + +[Term] +id: GO:0019745 +name: pentacyclic triterpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] +synonym: "pentacyclic triterpenoid anabolism" EXACT [] +synonym: "pentacyclic triterpenoid biosynthesis" EXACT [] +synonym: "pentacyclic triterpenoid formation" EXACT [] +synonym: "pentacyclic triterpenoid synthesis" EXACT [] +is_a: GO:0016104 ! triterpenoid biosynthetic process +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0019746 +name: hopanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] +synonym: "hopanoid anabolism" EXACT [] +synonym: "hopanoid biosynthesis" EXACT [] +synonym: "hopanoid formation" EXACT [] +synonym: "hopanoid synthesis" EXACT [] +is_a: GO:0016104 ! triterpenoid biosynthetic process +is_a: GO:0019744 ! hopanoid metabolic process + +[Term] +id: GO:0019747 +name: regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] +synonym: "regulation of isoprenoid metabolism" EXACT [] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0019748 +name: secondary metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] +subset: goslim_aspergillus +subset: goslim_chembl +subset: goslim_pir +subset: goslim_plant +subset: goslim_pombe +synonym: "secondary metabolism" EXACT [] +synonym: "secondary metabolite metabolic process" EXACT [] +synonym: "secondary metabolite metabolism" EXACT [] +xref: Wikipedia:Secondary_metabolism +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0019749 +name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] +is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport + +[Term] +id: GO:0019750 +name: chloroplast localization +namespace: biological_process +def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732] +synonym: "chloroplast localisation" EXACT [GOC:mah] +is_a: GO:0051644 ! plastid localization + +[Term] +id: GO:0019751 +name: polyol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [PMID:30240188] +synonym: "polyhydric alcohol metabolic process" EXACT [] +synonym: "polyol metabolism" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process + +[Term] +id: GO:0019752 +name: carboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] +synonym: "carboxylic acid metabolism" EXACT [] +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0019755 +name: one-carbon compound transport +namespace: biological_process +def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "one carbon compound transport" EXACT [] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0019756 +name: cyanogenic glycoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] +synonym: "cyanogenic glycoside anabolism" EXACT [] +synonym: "cyanogenic glycoside biosynthesis" EXACT [] +synonym: "cyanogenic glycoside formation" EXACT [] +synonym: "cyanogenic glycoside synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0042341 ! cyanogenic glycoside metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0080028 ! nitrile biosynthetic process + +[Term] +id: GO:0019757 +name: glycosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +synonym: "glycosinolate metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0019758 +name: glycosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +synonym: "glycosinolate anabolism" EXACT [] +synonym: "glycosinolate biosynthesis" EXACT [] +synonym: "glycosinolate formation" EXACT [] +synonym: "glycosinolate synthesis" EXACT [] +is_a: GO:0019757 ! glycosinolate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0019759 +name: glycosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] +synonym: "glycosinolate breakdown" EXACT [] +synonym: "glycosinolate catabolism" EXACT [] +synonym: "glycosinolate degradation" EXACT [] +is_a: GO:0019757 ! glycosinolate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0019760 +name: glucosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [GOC:curators] +synonym: "glucosinolate metabolism" EXACT [] +is_a: GO:0016143 ! S-glycoside metabolic process +is_a: GO:0019757 ! glycosinolate metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0019761 +name: glucosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] +synonym: "glucosinolate anabolism" EXACT [] +synonym: "glucosinolate biosynthesis" EXACT [] +synonym: "glucosinolate formation" EXACT [] +synonym: "glucosinolate synthesis" EXACT [] +is_a: GO:0016144 ! S-glycoside biosynthetic process +is_a: GO:0019758 ! glycosinolate biosynthetic process +is_a: GO:0019760 ! glucosinolate metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0019762 +name: glucosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] +synonym: "glucosinolate breakdown" EXACT [] +synonym: "glucosinolate catabolism" EXACT [] +synonym: "glucosinolate degradation" EXACT [] +xref: MetaCyc:PWY-5267 +is_a: GO:0016145 ! S-glycoside catabolic process +is_a: GO:0019759 ! glycosinolate catabolic process +is_a: GO:0019760 ! glucosinolate metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0019763 +name: immunoglobulin receptor activity +namespace: molecular_function +alt_id: GO:0016489 +def: "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, ISBN:0198547684] +synonym: "FC receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0019764 +name: obsolete high affinity Fc receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it is an unnecessary grouping term. +synonym: "high affinity Fc receptor activity" EXACT [] +is_obsolete: true +consider: GO:0019768 +consider: GO:0019771 + +[Term] +id: GO:0019765 +name: obsolete low affinity Fc receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:add] +comment: This term was made obsolete because it is undefined and is an unnecessary grouping term. +synonym: "low affinity Fc receptor activity" EXACT [] +is_obsolete: true +consider: GO:0019769 +consider: GO:0019772 + +[Term] +id: GO:0019766 +name: IgA receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0019767 +name: IgE receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0019768 +name: high-affinity IgE receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +synonym: "high affinity Fc receptor activity" RELATED [] +synonym: "high affinity IgE receptor activity" EXACT [] +is_a: GO:0019767 ! IgE receptor activity + +[Term] +id: GO:0019769 +name: low-affinity IgE receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +synonym: "low affinity Fc receptor activity" RELATED [] +synonym: "low affinity IgE receptor activity" EXACT [] +is_a: GO:0019767 ! IgE receptor activity + +[Term] +id: GO:0019770 +name: IgG receptor activity +namespace: molecular_function +def: "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +is_a: GO:0019763 ! immunoglobulin receptor activity + +[Term] +id: GO:0019771 +name: high-affinity IgG receptor activity +namespace: molecular_function +def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +synonym: "high affinity Fc receptor activity" RELATED [] +synonym: "high affinity IgG receptor activity" EXACT [] +is_a: GO:0019770 ! IgG receptor activity + +[Term] +id: GO:0019772 +name: low-affinity IgG receptor activity +namespace: molecular_function +def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +synonym: "low affinity Fc receptor activity" RELATED [] +synonym: "low affinity IgG receptor activity" EXACT [] +is_a: GO:0019770 ! IgG receptor activity + +[Term] +id: GO:0019773 +name: proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005839 ! proteasome core complex + +[Term] +id: GO:0019774 +name: proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005839 ! proteasome core complex + +[Term] +id: GO:0019775 +name: FAT10 transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages." [GOC:dph, GOC:mah, PMID:12826404] +synonym: "FAT10 conjugating enzyme activity" NARROW [] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0019776 +name: Atg8 ligase activity +namespace: molecular_function +def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] +synonym: "APG8 conjugating enzyme activity" EXACT [] +synonym: "APG8 ligase activity" EXACT [] +synonym: "Atg8 conjugating enzyme activity" EXACT [] +xref: Reactome:R-HSA-5681981 "ATG3 transfers LC3 from ATG7 to ATG3" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0019777 +name: Atg12 transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] +synonym: "APG12 conjugating enzyme activity" NARROW [] +synonym: "APG12 ligase activity" NARROW [] +synonym: "Atg12 conjugating enzyme activity" NARROW [] +synonym: "Atg12 ligase activity" NARROW [] +xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0019778 +name: Atg12 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019779 +name: Atg8 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +synonym: "APG7" EXACT [] +synonym: "APG8 activating enzyme activity" RELATED [GOC:vw] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019780 +name: FAT10 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019781 +name: NEDD8 activating enzyme activity +namespace: molecular_function +alt_id: GO:0019944 +def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] +synonym: "RUB1 activating enzyme activity" EXACT [] +xref: EC:6.2.1.64 +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019782 +name: ISG15 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +synonym: "UBE1L" NARROW [] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019783 +name: ubiquitin-like protein-specific protease activity +namespace: molecular_function +alt_id: GO:1904454 +alt_id: GO:1904455 +def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] +synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph] +synonym: "ubiquitin-like specific protease activity" NARROW [] +synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] +synonym: "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway" NARROW [] +synonym: "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway" NARROW [] +is_a: GO:0008234 ! cysteine-type peptidase activity + +[Term] +id: GO:0019784 +name: NEDD8-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] +synonym: "deneddylase activity" EXACT [GOC:dph] +xref: Reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8" +xref: Reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2" +xref: Reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes" +xref: Reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex" +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0019785 +name: ISG15-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] +xref: Reactome:R-HSA-1678841 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18" +xref: Reactome:R-HSA-5653786 "USP43 deISGylates ISG:K164,ISG:K168-PCNA" +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0019786 +name: Atg8-specific protease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] +synonym: "APG8-PE hydrolase" RELATED [] +synonym: "APG8-specific protease activity" RELATED [GOC:vw] +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0019787 +name: ubiquitin-like protein transferase activity +namespace: molecular_function +alt_id: GO:0008639 +alt_id: GO:0008640 +def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] +subset: goslim_drosophila +subset: goslim_pir +synonym: "E2" RELATED [] +synonym: "E3" RELATED [GOC:dph] +synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] +synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] +synonym: "small protein conjugating enzyme activity" NARROW [] +synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] +synonym: "ubiquitin-like-protein ligase activity" NARROW [] +xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" +xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" +is_a: GO:0016740 ! transferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0019788 +name: NEDD8 transferase activity +namespace: molecular_function +alt_id: GO:0016976 +alt_id: GO:0019945 +alt_id: GO:0042295 +def: "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] +synonym: "Hub1 conjugating enzyme activity" RELATED [] +synonym: "NEDD8 conjugating enzyme activity" RELATED [] +synonym: "RUB1 conjugating enzyme activity" RELATED [] +xref: Reactome:R-HSA-8951648 "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1" +xref: Reactome:R-HSA-8951661 "Transfer of NEDD8 to AcM-UBE2M" +xref: Reactome:R-HSA-8951764 "Transfer of NEDD8 to AcM-UBE2F" +xref: Reactome:R-HSA-8952044 "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex" +xref: Reactome:R-HSA-8952618 "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex" +xref: Reactome:R-HSA-8952638 "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex" +xref: Reactome:R-HSA-8956025 "AcM-UBE2M transfers NEDD8 to CUL9:RBX1" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0019789 +name: SUMO transferase activity +namespace: molecular_function +alt_id: GO:0016930 +alt_id: GO:0019949 +def: "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] +synonym: "SMT3 conjugating enzyme" RELATED [] +synonym: "SUMO conjugating enzyme activity" RELATED [] +xref: Reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)" +xref: Reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)" +xref: Reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)" +xref: Reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3" +xref: Reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3" +xref: Reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1" +xref: Reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1" +xref: Reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2" +xref: Reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1" +xref: Reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1" +xref: Reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2" +xref: Reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3" +xref: Reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1" +xref: Reactome:R-HSA-3000449 "UBC9 (UBE2I) SUMOylates RANGAP1 with SUMO, which targets RANGAP1 to RANBP2" +xref: Reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3" +xref: Reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1" +xref: Reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1" +xref: Reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1" +xref: Reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1" +xref: Reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1" +xref: Reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1" +xref: Reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1" +xref: Reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1" +xref: Reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3" +xref: Reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1" +xref: Reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1" +xref: Reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1" +xref: Reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1" +xref: Reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1" +xref: Reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2" +xref: Reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1" +xref: Reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1" +xref: Reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1" +xref: Reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1" +xref: Reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1" +xref: Reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1" +xref: Reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1" +xref: Reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1" +xref: Reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1" +xref: Reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1" +xref: Reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1" +xref: Reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3" +xref: Reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1" +xref: Reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1" +xref: Reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1" +xref: Reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3" +xref: Reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1" +xref: Reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1" +xref: Reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1" +xref: Reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1" +xref: Reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1" +xref: Reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1" +xref: Reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1" +xref: Reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1" +xref: Reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1" +xref: Reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1" +xref: Reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1" +xref: Reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2" +xref: Reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1" +xref: Reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2" +xref: Reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1" +xref: Reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2" +xref: Reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1" +xref: Reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3" +xref: Reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1" +xref: Reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1" +xref: Reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1" +xref: Reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1" +xref: Reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2" +xref: Reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1" +xref: Reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1" +xref: Reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1" +xref: Reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1" +xref: Reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3" +xref: Reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3" +xref: Reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1" +xref: Reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1" +xref: Reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1" +xref: Reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3" +xref: Reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3" +xref: Reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1" +xref: Reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3" +xref: Reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2" +xref: Reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1" +xref: Reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1" +xref: Reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2" +xref: Reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1" +xref: Reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3" +xref: Reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1" +xref: Reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3" +xref: Reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1" +xref: Reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1" +xref: Reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1" +xref: Reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3" +xref: Reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1" +xref: Reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1" +xref: Reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1" +xref: Reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3" +xref: Reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1" +xref: Reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1" +xref: Reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1" +xref: Reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3" +xref: Reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1" +xref: Reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)" +xref: Reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1" +xref: Reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1" +xref: Reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1" +xref: Reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1" +xref: Reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1" +xref: Reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)" +xref: Reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2" +xref: Reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3" +xref: Reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1." +xref: Reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1" +xref: Reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1" +xref: Reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3" +xref: Reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3" +xref: Reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3" +xref: Reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1" +xref: Reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1" +xref: Reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1" +xref: Reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1" +xref: Reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3" +xref: Reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3" +xref: Reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1" +xref: Reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1" +xref: Reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1" +xref: Reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1" +xref: Reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs" +xref: Reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1" +xref: Reactome:R-HSA-6790454 "SUMOylation of XPC" +xref: Reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2" +xref: Reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2" +xref: Reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0019790 +name: obsolete ubiquitin-like hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +synonym: "ubiquitin-like hydrolase activity" EXACT [] +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019791 +name: obsolete FAT10 hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +synonym: "FAT10 hydrolase activity" EXACT [] +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019792 +name: obsolete APG12 hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +synonym: "APG12 hydrolase activity" EXACT [] +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0019793 +name: obsolete ISG15 carrier activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] +comment: This term was made obsolete because it is gene product-specific. +synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] +synonym: "ISG15 carrier activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019794 +name: obsolete nonprotein amino acid metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. +synonym: "nonprotein amino acid metabolic process" EXACT [] +synonym: "nonprotein amino acid metabolism" EXACT [] +is_obsolete: true +replaced_by: GO:0006520 + +[Term] +id: GO:0019795 +name: obsolete nonprotein amino acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma] +comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. +synonym: "nonprotein amino acid anabolism" EXACT [] +synonym: "nonprotein amino acid biosynthesis" EXACT [] +synonym: "nonprotein amino acid biosynthetic process" EXACT [] +synonym: "nonprotein amino acid formation" EXACT [] +synonym: "nonprotein amino acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0008652 + +[Term] +id: GO:0019796 +name: obsolete nonprotein amino acid catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. +synonym: "nonprotein amino acid breakdown" EXACT [] +synonym: "nonprotein amino acid catabolic process" EXACT [] +synonym: "nonprotein amino acid catabolism" EXACT [] +synonym: "nonprotein amino acid degradation" EXACT [] +is_obsolete: true +replaced_by: GO:0009063 + +[Term] +id: GO:0019797 +name: procollagen-proline 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7, RHEA:22872] +synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.7] +synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" RELATED [EC:1.14.11.7] +synonym: "proline,2-oxoglutarate 3-dioxygenase activity" RELATED [EC:1.14.11.7] +synonym: "prolyl 3-hydroxylase activity" BROAD [EC:1.14.11.7] +synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" RELATED [EC:1.14.11.7] +synonym: "protocollagen proline 3-hydroxylase activity" RELATED [EC:1.14.11.7] +xref: EC:1.14.11.7 +xref: KEGG_REACTION:R03218 +xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN +xref: Reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen" +xref: RHEA:22872 +is_a: GO:0019798 ! procollagen-proline dioxygenase activity +is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity + +[Term] +id: GO:0019798 +name: procollagen-proline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [GOC:mah, PMID:4371784] +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0019799 +name: tubulin N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" RELATED [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" RELATED [EC:2.3.1.108] +synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" RELATED [EC:2.3.1.108] +synonym: "alpha-tubulin acetylase activity" RELATED [EC:2.3.1.108] +synonym: "alpha-tubulin acetyltransferase activity" RELATED [EC:2.3.1.108] +synonym: "alpha-tubulin N-acetyltransferase activity" RELATED [EC:2.3.1.108] +synonym: "TAT activity" RELATED [EC:2.3.1.108] +synonym: "tubulin acetyltransferase activity" RELATED [EC:2.3.1.108] +xref: EC:2.3.1.108 +xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN +xref: RHEA:15277 +is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity + +[Term] +id: GO:0019800 +name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan +namespace: biological_process +def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219] +synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT [] +xref: RESID:AA0219 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030204 ! chondroitin sulfate metabolic process + +[Term] +id: GO:0019801 +name: cyclization of asparagine involved in intein-mediated protein splicing +namespace: biological_process +def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302] +comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. +synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb] +xref: RESID:AA0302 +is_a: GO:0006528 ! asparagine metabolic process +relationship: part_of GO:0016539 ! intein-mediated protein splicing + +[Term] +id: GO:0019802 +name: cyclization of glutamine involved in intein-mediated protein splicing +namespace: biological_process +def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303] +comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. +synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb] +xref: RESID:AA0303 +is_a: GO:0006541 ! glutamine metabolic process +relationship: part_of GO:0016539 ! intein-mediated protein splicing + +[Term] +id: GO:0019803 +name: peptidyl-aspartic acid carboxylation +namespace: biological_process +def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304] +xref: RESID:AA0304 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018214 ! protein carboxylation + +[Term] +id: GO:0019804 +name: obsolete quinolinate synthetase complex +namespace: cellular_component +def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] +comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers. +synonym: "quinolinate synthetase complex" EXACT [] +is_obsolete: true +consider: GO:0008743 +consider: GO:0008987 + +[Term] +id: GO:0019805 +name: quinolinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] +synonym: "quinolinate anabolism" EXACT [] +synonym: "quinolinate biosynthesis" EXACT [] +synonym: "quinolinate formation" EXACT [] +synonym: "quinolinate synthesis" EXACT [] +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046874 ! quinolinate metabolic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process + +[Term] +id: GO:0019806 +name: bromide peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.18] +synonym: "bromoperoxidase activity" EXACT [] +xref: EC:1.11.1.18 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0019807 +name: aspartoacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] +synonym: "acetyl-aspartic deaminase activity" RELATED [EC:3.5.1.15] +synonym: "acylase II" RELATED [EC:3.5.1.15] +synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] +synonym: "N-acetylaspartate amidohydrolase activity" RELATED [EC:3.5.1.15] +synonym: "N-acyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.15] +xref: EC:3.5.1.15 +xref: MetaCyc:ASPARTOACYLASE-RXN +xref: Reactome:R-HSA-5691507 "ASPA deacetylates NAA to acetate and L-aspartate" +xref: RHEA:10872 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019808 +name: polyamine binding +namespace: molecular_function +def: "Binding to a polyamine, an organic compound containing two or more amino groups." [GOC:ai] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0019809 +name: spermidine binding +namespace: molecular_function +def: "Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +is_a: GO:0019808 ! polyamine binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0019810 +name: putrescine binding +namespace: molecular_function +def: "Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] +is_a: GO:0019808 ! polyamine binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0019811 +name: cocaine binding +namespace: molecular_function +def: "Binding to cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732] +is_a: GO:0043169 ! cation binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0019812 +name: type I site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] +synonym: "type I restriction enzyme complex" EXACT [] +is_a: GO:1905347 ! endodeoxyribonuclease complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0019813 +name: type III site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] +synonym: "type III restriction enzyme complex" EXACT [] +is_a: GO:1905347 ! endodeoxyribonuclease complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0019814 +name: immunoglobulin complex +namespace: cellular_component +def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196] +comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +subset: goslim_pir +synonym: "antibody" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0019815 +name: B cell receptor complex +namespace: cellular_component +alt_id: GO:0042570 +def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149] +comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "antibody" RELATED [GOC:mah] +synonym: "B cell receptor accessory molecule complex" RELATED [] +synonym: "B lymphocyte receptor complex" EXACT [] +synonym: "B-cell receptor complex" EXACT [] +synonym: "B-lymphocyte receptor complex" EXACT [] +synonym: "BCR complex" EXACT [] +synonym: "immunoglobulin complex, membrane bound" EXACT [] +is_a: GO:0019814 ! immunoglobulin complex +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0019816 +name: obsolete B cell receptor accessory molecule complex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it represents a molecule and not a location or complex. +synonym: "B cell receptor accessory molecule complex" EXACT [] +is_obsolete: true +consider: GO:0019815 + +[Term] +id: GO:0019817 +name: vesicle fusion with peroxisome +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0007031 ! peroxisome organization + +[Term] +id: GO:0019819 +name: P1 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019820 +name: P2 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019821 +name: P3 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019822 +name: P4 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019823 +name: P5 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019824 +name: P6 peroxisome +namespace: cellular_component +def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] +comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. +synonym: "peroxisome vesicle" BROAD [] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0019825 +name: oxygen binding +namespace: molecular_function +def: "Binding to oxygen (O2)." [GOC:jl] +subset: goslim_pir +subset: goslim_plant +synonym: "cytochrome P450" NARROW [] +synonym: "cytochrome P450 activity" RELATED [] +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0019826 +name: oxygen sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah] +is_a: GO:0019825 ! oxygen binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0019827 +name: stem cell population maintenance +namespace: biological_process +def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] +synonym: "maintenance of pluripotency" RELATED [GOC:vk] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0098727 ! maintenance of cell number + +[Term] +id: GO:0019828 +name: aspartic-type endopeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] +synonym: "aspartic protease inhibitor activity" NARROW [] +is_a: GO:0004866 ! endopeptidase inhibitor activity + +[Term] +id: GO:0019829 +name: ATPase-coupled cation transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] +synonym: "ATP-dependent cation transmembrane transporter activity" EXACT [] +synonym: "cation ABC transporter" NARROW [] +synonym: "cation-transporting ATPase activity" EXACT [] +synonym: "plasma membrane cation-transporting ATPase" NARROW [] +xref: Reactome:R-HSA-5251989 "ATP13A4,5 transport divalent ions from extracellular region to cytosol" +xref: Reactome:R-HSA-5692480 "ATP13A2 transports cations from cytosol to lysosomal lumen" +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0019830 +name: obsolete cadmium sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "cadmium sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046686 + +[Term] +id: GO:0019831 +name: obsolete chromate sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "chromate sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046687 + +[Term] +id: GO:0019832 +name: obsolete mercuric sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "mercuric sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046689 + +[Term] +id: GO:0019833 +name: obsolete ice nucleation activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl] +comment: This term was made obsolete because it represents a biological process. +synonym: "ice nucleation activity" EXACT [] +is_obsolete: true +consider: GO:0042309 +consider: GO:0050825 + +[Term] +id: GO:0019834 +name: phospholipase A2 inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of phospholipase A2." [GOC:ai] +is_a: GO:0004859 ! phospholipase inhibitor activity + +[Term] +id: GO:0019835 +name: cytolysis +namespace: biological_process +def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] +subset: goslim_chembl +synonym: "autolysin activity" RELATED [] +synonym: "bacteriocin activity" RELATED [] +synonym: "bacteriolytic toxin activity" RELATED [] +synonym: "holin" RELATED [] +synonym: "lysin activity" RELATED [] +synonym: "lysis" BROAD [] +synonym: "necrosis" RELATED [] +xref: Wikipedia:Cytolysis +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0019836 +name: hemolysis by symbiont of host erythrocytes +namespace: biological_process +def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354] +synonym: "haemolysis in host" EXACT [] +synonym: "hemolysin activity" RELATED [] +synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232] +synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232] +synonym: "pathogenesis" RELATED [] +synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001897 ! cytolysis by symbiont of host cells + +[Term] +id: GO:0019837 +name: obsolete herbicide susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "herbicide susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0009635 + +[Term] +id: GO:0019838 +name: growth factor binding +namespace: molecular_function +def: "Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] +subset: goslim_chembl +synonym: "neurotrophin TRK receptor activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019840 +name: isoprenoid binding +namespace: molecular_function +def: "Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] +subset: goslim_pir +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0019841 +name: retinol binding +namespace: molecular_function +def: "Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [GOC:curators] +synonym: "vitamin A1 alcohol binding" EXACT [] +synonym: "vitamin A1 binding" EXACT [] +is_a: GO:0005501 ! retinoid binding +is_a: GO:0019842 ! vitamin binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0019842 +name: vitamin binding +namespace: molecular_function +def: "Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: goslim_metagenomics +subset: goslim_pir +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0019843 +name: rRNA binding +namespace: molecular_function +alt_id: GO:0000944 +def: "Binding to a ribosomal RNA." [GOC:jl] +subset: goslim_chembl +subset: goslim_yeast +synonym: "base pairing with rRNA" NARROW [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0019844 +name: obsolete endotoxin activity +namespace: molecular_function +def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "endotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0005622 +consider: GO:0090729 + +[Term] +id: GO:0019845 +name: obsolete exotoxin activity +namespace: molecular_function +def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "exotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0005576 +consider: GO:0090729 + +[Term] +id: GO:0019846 +name: obsolete enterotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "enterotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0090729 + +[Term] +id: GO:0019847 +name: obsolete neurotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "neurotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0090729 + +[Term] +id: GO:0019848 +name: obsolete conotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "conotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0019855 +consider: GO:0046929 + +[Term] +id: GO:0019849 +name: obsolete cytotoxin activity +namespace: molecular_function +def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl] +comment: This term was made obsolete because it represents a class of gene products. +synonym: "cytotoxin activity" EXACT [] +is_obsolete: true +consider: GO:0090729 + +[Term] +id: GO:0019852 +name: L-ascorbic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:jl, ISBN:0198506732] +synonym: "ascorbate metabolic process" EXACT [] +synonym: "ascorbate metabolism" EXACT [] +synonym: "L-ascorbic acid metabolism" EXACT [] +synonym: "vitamin C metabolic process" EXACT [] +synonym: "vitamin C metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:0019853 +name: L-ascorbic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:ma, ISBN:0198547684] +synonym: "ascorbate biosynthesis" EXACT [] +synonym: "ascorbate biosynthetic process" EXACT [] +synonym: "L-ascorbic acid anabolism" EXACT [] +synonym: "L-ascorbic acid biosynthesis" EXACT [] +synonym: "L-ascorbic acid formation" EXACT [] +synonym: "L-ascorbic acid synthesis" EXACT [] +synonym: "vitamin C biosynthesis" EXACT [] +synonym: "vitamin C biosynthetic process" EXACT [] +xref: MetaCyc:PWY-882 +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0046364 ! monosaccharide biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0019854 +name: L-ascorbic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [GOC:go_curators] +synonym: "ascorbate catabolic process" EXACT [] +synonym: "ascorbate catabolism" EXACT [] +synonym: "L-ascorbic acid breakdown" EXACT [] +synonym: "L-ascorbic acid catabolism" EXACT [] +synonym: "L-ascorbic acid degradation" EXACT [] +synonym: "vitamin C catabolic process" EXACT [] +synonym: "vitamin C catabolism" EXACT [] +xref: MetaCyc:PWY0-301 +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0046365 ! monosaccharide catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901335 ! lactone catabolic process + +[Term] +id: GO:0019855 +name: calcium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a calcium channel." [GOC:mah] +is_a: GO:0005246 ! calcium channel regulator activity +is_a: GO:0008200 ! ion channel inhibitor activity + +[Term] +id: GO:0019856 +name: pyrimidine nucleobase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] +synonym: "pyrimidine base anabolism" EXACT [] +synonym: "pyrimidine base biosynthesis" EXACT [] +synonym: "pyrimidine base biosynthetic process" EXACT [GOC:go_curators] +synonym: "pyrimidine base formation" EXACT [] +synonym: "pyrimidine base synthesis" EXACT [] +is_a: GO:0006206 ! pyrimidine nucleobase metabolic process +is_a: GO:0046112 ! nucleobase biosynthetic process +is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process + +[Term] +id: GO:0019857 +name: 5-methylcytosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai] +synonym: "5-methylcytosine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:0019858 +name: cytosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai] +synonym: "cytosine metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0019859 +name: thymine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +synonym: "thymine metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0019860 +name: uracil metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +synonym: "uracil metabolism" EXACT [] +is_a: GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0019861 +name: obsolete flagellum +namespace: cellular_component +alt_id: GO:0008223 +def: "OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [UniProtKB-KW:KW-0282] +comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum ; GO:0009288'. +synonym: "flagellum" EXACT [] +xref: Wikipedia:Flagellum +is_obsolete: true +consider: GO:0005929 +consider: GO:0009288 + +[Term] +id: GO:0019862 +name: IgA binding +namespace: molecular_function +def: "Binding to an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019863 +name: IgE binding +namespace: molecular_function +def: "Binding to an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019864 +name: IgG binding +namespace: molecular_function +def: "Binding to an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149] +subset: goslim_chembl +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0019865 +name: immunoglobulin binding +namespace: molecular_function +def: "Binding to an immunoglobulin." [GOC:ma] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0019866 +name: organelle inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] +comment: See also the cellular component term 'outer membrane ; GO:0019867'. +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0019867 +name: outer membrane +namespace: cellular_component +def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] +subset: goslim_metagenomics +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0019869 +name: chloride channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a chloride channel." [GOC:mah] +is_a: GO:0017081 ! chloride channel regulator activity + +[Term] +id: GO:0019870 +name: potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a potassium channel." [GOC:mah] +is_a: GO:0008200 ! ion channel inhibitor activity +is_a: GO:0015459 ! potassium channel regulator activity + +[Term] +id: GO:0019871 +name: sodium channel inhibitor activity +namespace: molecular_function +alt_id: GO:0019868 +def: "Binds to and stops, prevents, or reduces the activity of a sodium channel." [GOC:mah] +is_a: GO:0008200 ! ion channel inhibitor activity +is_a: GO:0017080 ! sodium channel regulator activity + +[Term] +id: GO:0019872 +name: streptomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators] +synonym: "streptomycin anabolism" EXACT [] +synonym: "streptomycin biosynthesis" EXACT [] +synonym: "streptomycin formation" EXACT [] +synonym: "streptomycin synthesis" EXACT [] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0046343 ! streptomycin metabolic process + +[Term] +id: GO:0019873 +name: obsolete tellurium sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "tellurium sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046690 + +[Term] +id: GO:0019874 +name: 6-aminohexanoate-cyclic-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16225] +synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" RELATED [EC:3.5.2.12] +xref: EC:3.5.2.12 +xref: KEGG_REACTION:R03448 +xref: MetaCyc:3.5.2.12-RXN +xref: RHEA:16225 +xref: UM-BBD_reactionID:r1097 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0019875 +name: 6-aminohexanoate-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] +synonym: "6-aminohexanoic acid oligomer hydrolase activity" RELATED [EC:3.5.1.46] +synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" RELATED [EC:3.5.1.46] +xref: EC:3.5.1.46 +xref: MetaCyc:RXN-3962 +xref: RHEA:21364 +xref: UM-BBD_enzymeID:e0673 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0019876 +name: nylon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549] +synonym: "nylon breakdown" EXACT [] +synonym: "nylon catabolism" EXACT [] +synonym: "nylon degradation" EXACT [] +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042198 ! nylon metabolic process + +[Term] +id: GO:0019877 +name: diaminopimelate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684] +synonym: "diaminopimelate anabolism" EXACT [] +synonym: "diaminopimelate biosynthesis" EXACT [] +synonym: "diaminopimelate formation" EXACT [] +synonym: "diaminopimelate synthesis" EXACT [] +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046451 ! diaminopimelate metabolic process + +[Term] +id: GO:0019878 +name: lysine biosynthetic process via aminoadipic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators] +synonym: "lysine anabolism via aminoadipic acid" EXACT [] +synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT [] +synonym: "lysine biosynthesis, aminoadipic pathway" EXACT [] +synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT [] +synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT [] +synonym: "lysine formation via aminoadipic acid" EXACT [] +synonym: "lysine synthesis via aminoadipic acid" EXACT [] +is_a: GO:0009085 ! lysine biosynthetic process + +[Term] +id: GO:0019879 +name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine +namespace: biological_process +def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg] +comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. +synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT [] +synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT [] +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0019880 +name: obsolete bacteriocin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "bacteriocin susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046678 + +[Term] +id: GO:0019881 +name: obsolete streptomycin susceptibility/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. +synonym: "streptomycin susceptibility/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046679 + +[Term] +id: GO:0019882 +name: antigen processing and presentation +namespace: biological_process +alt_id: GO:0030333 +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +synonym: "antigen presentation" EXACT [] +synonym: "antigen processing" EXACT [] +xref: Wikipedia:Antigen_presentation +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0019883 +name: antigen processing and presentation of endogenous antigen +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +synonym: "antigen presentation, endogenous antigen" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0019884 +name: antigen processing and presentation of exogenous antigen +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] +synonym: "antigen presentation, exogenous antigen" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0019885 +name: antigen processing and presentation of endogenous peptide antigen via MHC class I +namespace: biological_process +alt_id: GO:0048004 +def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "antigen presentation, endogenous peptide antigen" BROAD [] +synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [] +synonym: "antigen processing, endogenous antigen via MHC class I" BROAD [] +synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen + +[Term] +id: GO:0019886 +name: antigen processing and presentation of exogenous peptide antigen via MHC class II +namespace: biological_process +alt_id: GO:0042591 +alt_id: GO:0048005 +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD [] +synonym: "antigen presentation, exogenous peptide antigen" BROAD [] +synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT [] +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen +is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II + +[Term] +id: GO:0019887 +name: protein kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0019888 +name: protein phosphatase regulator activity +namespace: molecular_function +alt_id: GO:0008599 +alt_id: GO:0008601 +alt_id: GO:0030359 +alt_id: GO:0030362 +def: "Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:ai] +synonym: "calcineurin regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "calcineurin, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase 2 regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase 2, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase 3 regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase 3, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase type 1 regulator activity" NARROW [] +synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] +synonym: "protein phosphatase type 2A regulator activity" NARROW [] +synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] +synonym: "protein phosphatase type 2B regulator activity" NARROW [] +synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] +synonym: "protein phosphatase type 4 regulator activity" NARROW [] +synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] +xref: Reactome:R-HSA-180038 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function" +is_a: GO:0019208 ! phosphatase regulator activity + +[Term] +id: GO:0019889 +name: pteridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732] +synonym: "pteridine metabolism" EXACT [] +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:0019893 +name: obsolete DNA replication inhibitor +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +synonym: "DNA replication inhibitor" EXACT [] +is_obsolete: true +replaced_by: GO:0008156 + +[Term] +id: GO:0019894 +name: kinesin binding +namespace: molecular_function +def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0019895 +name: obsolete kinesin-associated mitochondrial adaptor activity +namespace: molecular_function +def: "OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622] +comment: This term was obsoleted because it represents the function of a specific protein. +is_obsolete: true + +[Term] +id: GO:0019896 +name: axonal transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] +subset: goslim_synapse +synonym: "axon transport of mitochondria" EXACT [] +is_a: GO:0047497 ! mitochondrion transport along microtubule +is_a: GO:0098930 ! axonal transport + +[Term] +id: GO:0019897 +name: extrinsic component of plasma membrane +namespace: cellular_component +alt_id: GO:0000157 +def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] +synonym: "extrinsic to plasma membrane" EXACT [] +synonym: "juxtamembrane" BROAD [] +synonym: "peripheral plasma membrane protein" EXACT [] +is_a: GO:0019898 ! extrinsic component of membrane +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0019898 +name: extrinsic component of membrane +namespace: cellular_component +alt_id: GO:0030396 +def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] +comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. +subset: goslim_metagenomics +synonym: "extrinsic to membrane" EXACT [] +synonym: "peripheral membrane protein" EXACT [] +xref: Wikipedia:Peripheral_membrane_protein +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0019899 +name: enzyme binding +namespace: molecular_function +def: "Binding to an enzyme, a protein with catalytic activity." [GOC:jl] +subset: goslim_chembl +subset: goslim_yeast +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019900 +name: kinase binding +namespace: molecular_function +def: "Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0019901 +name: protein kinase binding +namespace: molecular_function +def: "Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] +is_a: GO:0019900 ! kinase binding + +[Term] +id: GO:0019902 +name: phosphatase binding +namespace: molecular_function +def: "Binding to a phosphatase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0019903 +name: protein phosphatase binding +namespace: molecular_function +def: "Binding to a protein phosphatase." [GOC:jl] +is_a: GO:0019902 ! phosphatase binding + +[Term] +id: GO:0019904 +name: protein domain specific binding +namespace: molecular_function +def: "Binding to a specific domain of a protein." [GOC:go_curators] +subset: goslim_chembl +synonym: "protein domain-specific binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019905 +name: syntaxin binding +namespace: molecular_function +alt_id: GO:0030347 +alt_id: GO:0030349 +alt_id: GO:0050430 +alt_id: GO:0051535 +def: "Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732] +synonym: "syntaxin-13 binding" NARROW [] +synonym: "syntaxin-2 binding" NARROW [] +synonym: "syntaxin-5 binding" NARROW [] +synonym: "syntaxin-6 binding" NARROW [] +is_a: GO:0000149 ! SNARE binding + +[Term] +id: GO:0019907 +name: cyclin-dependent protein kinase activating kinase holoenzyme complex +namespace: cellular_component +def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210] +synonym: "CAK complex" EXACT [] +synonym: "CDK-activating kinase complex" EXACT [] +is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex +is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex +is_a: GO:0150005 ! enzyme activator complex + +[Term] +id: GO:0019908 +name: nuclear cyclin-dependent protein kinase holoenzyme complex +namespace: cellular_component +def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] +synonym: "CDK holoenzyme" BROAD [] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0019909 +name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity +namespace: molecular_function +def: "Binds to and modulates of the activity of [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] +synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0019910 +name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502] +comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. +is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0019911 +name: structural constituent of myelin sheath +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0019912 +name: cyclin-dependent protein kinase activating kinase activity +namespace: molecular_function +alt_id: GO:0019913 +def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] +synonym: "CAK" EXACT [] +synonym: "cdk-activating kinase activity" EXACT [] +synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] +is_a: GO:0004672 ! protein kinase activity +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0019914 +name: cyclin-dependent protein kinase activating kinase regulator activity +namespace: molecular_function +def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] +synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0019915 +name: lipid storage +namespace: biological_process +def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] +synonym: "lipid retention" EXACT [GOC:dph, GOC:tb] +synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb] +synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb] +synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb] +synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb] +synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb] +synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb] +synonym: "storage of lipids" EXACT [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0010876 ! lipid localization + +[Term] +id: GO:0019916 +name: peptidyl-D-alanine racemization, direct +namespace: biological_process +def: "The racemization of peptidyl-alanine." [RESID:AA0191] +xref: RESID:AA0191 +is_a: GO:0019122 ! peptidyl-D-alanine racemization + +[Term] +id: GO:0019917 +name: peptidyl-D-alanine racemization via peptidyl-L-serine +namespace: biological_process +def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191] +xref: RESID:AA0191 +is_a: GO:0019122 ! peptidyl-D-alanine racemization + +[Term] +id: GO:0019918 +name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine +namespace: biological_process +def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] +xref: RESID:AA0067 +xref: RESID:AA0069 +is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation + +[Term] +id: GO:0019919 +name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine +namespace: biological_process +def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] +synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT [] +xref: RESID:AA0068 +xref: RESID:AA0069 +is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation + +[Term] +id: GO:0019920 +name: peptidyl-1-thioglycine biosynthetic process, internal +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT [] +synonym: "peptidyl-1-thioglycine formation, internal" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine + +[Term] +id: GO:0019921 +name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] +synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT [] +synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT [] +synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT [] +xref: RESID:AA0265 +is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine + +[Term] +id: GO:0019922 +name: protein-chromophore linkage via peptidyl-cysteine +namespace: biological_process +def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma] +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019923 +name: alpha-1-microglobulin-chromophore linkage +namespace: biological_process +def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224] +xref: RESID:AA0224 +is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine + +[Term] +id: GO:0019926 +name: peptidyl-tryptophan oxidation to tryptophyl quinone +namespace: biological_process +def: "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148] +comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. +is_a: GO:0018158 ! protein oxidation +is_a: GO:0018211 ! peptidyl-tryptophan modification +relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone + +[Term] +id: GO:0019927 +name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone +namespace: biological_process +def: "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313] +xref: RESID:AA0313 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019928 +name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid +namespace: biological_process +def: "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314] +xref: RESID:AA0314 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0019929 +name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid +namespace: biological_process +def: "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315] +xref: RESID:AA0315 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0019930 +name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid +namespace: biological_process +def: "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT [] +synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT [] +xref: RESID:AA0316 +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0019931 +name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine +namespace: biological_process +def: "The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312] +xref: RESID:AA0312 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0019932 +name: second-messenger-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell." [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system] +synonym: "second messenger mediated signaling" EXACT [] +synonym: "second messenger mediated signalling" EXACT [] +synonym: "second messenger-mediated signaling" EXACT [] +synonym: "second messenger-mediated signalling" EXACT [] +synonym: "second-messenger-mediated signal transduction" EXACT [GOC:signaling] +synonym: "second-messenger-mediated signalling" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0019933 +name: cAMP-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] +synonym: "3',5' cAMP-mediated signaling" EXACT [] +synonym: "3',5' cAMP-mediated signalling" EXACT [] +synonym: "3',5'-cAMP-mediated signaling" EXACT [] +synonym: "3',5'-cAMP-mediated signalling" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT [] +synonym: "cAMP signaling" EXACT [] +synonym: "cAMP signalling" EXACT [] +synonym: "cAMP-mediated signal transduction" EXACT [] +synonym: "cAMP-mediated signalling" EXACT [] +synonym: "cyclic AMP-mediated signaling" EXACT [] +synonym: "cyclic AMP-mediated signalling" EXACT [] +is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling + +[Term] +id: GO:0019934 +name: cGMP-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] +synonym: "cGMP-mediated signalling" EXACT [] +is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling + +[Term] +id: GO:0019935 +name: cyclic-nucleotide-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] +synonym: "cyclic-nucleotide-mediated signalling" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0019936 +name: obsolete inositol phospholipid-mediated signaling +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ceb] +comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling. +synonym: "inositol phospholipid-mediated signaling" EXACT [] +synonym: "inositol phospholipid-mediated signalling" EXACT [] +is_obsolete: true +consider: GO:0048016 +consider: GO:0048017 + +[Term] +id: GO:0019937 +name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic +namespace: biological_process +def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294] +xref: RESID:AA0294 +is_a: GO:0018419 ! protein catenane formation +is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine + +[Term] +id: GO:0019938 +name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic +namespace: biological_process +alt_id: GO:0042266 +def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294] +xref: RESID:AA0294 +is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine + +[Term] +id: GO:0019939 +name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308] +synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT [] +synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] +xref: RESID:AA0308 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0045234 ! protein palmitoleylation + +[Term] +id: GO:0019940 +name: obsolete SUMO-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein. +synonym: "SUMO-dependent protein breakdown" EXACT [] +synonym: "SUMO-dependent protein catabolic process" EXACT [] +synonym: "SUMO-dependent protein catabolism" EXACT [] +synonym: "SUMO-dependent protein degradation" EXACT [] +is_obsolete: true +consider: GO:0016925 +consider: GO:0016926 + +[Term] +id: GO:0019941 +name: modification-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] +synonym: "modification-dependent protein breakdown" EXACT [] +synonym: "modification-dependent protein catabolism" EXACT [] +synonym: "modification-dependent protein degradation" EXACT [] +synonym: "modification-dependent proteolysis" EXACT [GOC:rl] +synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl] +synonym: "modification-initiated protein catabolism" EXACT [GOC:rl] +synonym: "modification-initiated proteolysis" EXACT [GOC:rl] +synonym: "protein degradation tagging activity" RELATED [] +synonym: "protein-ligand-dependent protein catabolic process" NARROW [] +synonym: "protein-ligand-dependent protein catabolism" NARROW [] +is_a: GO:0043632 ! modification-dependent macromolecule catabolic process +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0019942 +name: obsolete NEDD8 class-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl] +comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. +synonym: "NEDD8 class-dependent protein breakdown" EXACT [] +synonym: "NEDD8 class-dependent protein catabolic process" EXACT [] +synonym: "NEDD8 class-dependent protein catabolism" EXACT [] +synonym: "NEDD8 class-dependent protein degradation" EXACT [] +synonym: "RUB1-dependent protein catabolic process" EXACT [] +synonym: "RUB1-dependent protein catabolism" EXACT [] +synonym: "RUB1-dependent protein degradation" EXACT [] +is_obsolete: true +consider: GO:0045116 + +[Term] +id: GO:0019948 +name: SUMO activating enzyme activity +namespace: molecular_function +alt_id: GO:0017115 +def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] +synonym: "SMT3 activating enzyme" EXACT [] +synonym: "SUMO E1 activator enzyme" EXACT [] +xref: Reactome:R-HSA-2990833 "Conjugation of SUMO1 to UBA2:SAE1" +xref: Reactome:R-HSA-2993781 "Conjugation of SUMO3 to UBA2:SAE1" +xref: Reactome:R-HSA-2993784 "Conjugation of SUMO2 to UBA2:SAE1" +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0019950 +name: obsolete SMT3-dependent protein catabolic process +namespace: biological_process +alt_id: GO:0019946 +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231] +comment: See issue #21890. SMT3 protein mod is sumoylation and does not always lead to degradation. +synonym: "SMT3-dependent protein breakdown" EXACT [] +synonym: "SMT3-dependent protein catabolism" EXACT [] +synonym: "SMT3-dependent protein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019953 +name: sexual reproduction +namespace: biological_process +def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, ISBN:0387520546, Wikipedia:Sexual_reproduction] +comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. +xref: Wikipedia:Sexual_reproduction +is_a: GO:0000003 ! reproduction +is_a: GO:0044703 ! multi-organism reproductive process + +[Term] +id: GO:0019954 +name: asexual reproduction +namespace: biological_process +def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] +synonym: "parthenogenesis" RELATED [Wikipedia:Parthenogenesis] +xref: Wikipedia:Asexual_reproduction +is_a: GO:0000003 ! reproduction + +[Term] +id: GO:0019955 +name: cytokine binding +namespace: molecular_function +alt_id: GO:0019965 +def: "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] +synonym: "IL binding" NARROW [] +synonym: "interleukin binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0019956 +name: chemokine binding +namespace: molecular_function +def: "Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019957 +name: C-C chemokine binding +namespace: molecular_function +def: "Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019958 +name: C-X-C chemokine binding +namespace: molecular_function +def: "Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019959 +name: interleukin-8 binding +namespace: molecular_function +def: "Binding to interleukin-8." [GOC:jl] +synonym: "IL-8 binding" EXACT [] +is_a: GO:0019958 ! C-X-C chemokine binding + +[Term] +id: GO:0019960 +name: C-X3-C chemokine binding +namespace: molecular_function +def: "Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] +is_a: GO:0019956 ! chemokine binding + +[Term] +id: GO:0019961 +name: interferon binding +namespace: molecular_function +def: "Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [PMID:9607096, Wikipedia:Interferon] +synonym: "IFN binding" EXACT [GOC:mah] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019962 +name: type I interferon binding +namespace: molecular_function +def: "Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "interferon-alpha binding" NARROW [] +synonym: "interferon-alpha/beta binding" NARROW [] +synonym: "interferon-beta binding" NARROW [] +synonym: "interferon-delta binding" NARROW [] +synonym: "interferon-epsilon binding" NARROW [] +synonym: "interferon-kappa binding" NARROW [] +synonym: "interferon-omega binding" NARROW [] +synonym: "interferon-tau binding" NARROW [] +synonym: "interferon-zeta binding" NARROW [] +synonym: "type I IFN binding" EXACT [GOC:mah] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0019964 +name: interferon-gamma binding +namespace: molecular_function +def: "Binding to interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] +synonym: "IFN-gamma binding" EXACT [GOC:mah] +synonym: "IFNG binding" EXACT [GOC:mah] +synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0019966 +name: interleukin-1 binding +namespace: molecular_function +def: "Binding to interleukin-1." [GOC:jl, ISBN:0198506732] +synonym: "IL-1 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019969 +name: interleukin-10 binding +namespace: molecular_function +def: "Binding to interleukin-10." [GOC:jl] +synonym: "IL-10 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019970 +name: interleukin-11 binding +namespace: molecular_function +def: "Binding to interleukin-11." [GOC:jl] +synonym: "IL-11 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019972 +name: interleukin-12 binding +namespace: molecular_function +def: "Binding to interleukin-12." [GOC:jl] +synonym: "IL-12 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019973 +name: interleukin-13 binding +namespace: molecular_function +def: "Binding to interleukin-13." [GOC:jl] +synonym: "IL-13 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019974 +name: obsolete interleukin-14 binding +namespace: molecular_function +def: "OBSOLETE. Binding to interleukin-14." [GOC:jl] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "IL-14 binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019975 +name: interleukin-17 binding +namespace: molecular_function +def: "Binding to a member of the interleukin-17 family of cytokines." [GOC:add, GOC:jl] +synonym: "IL-17 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019976 +name: interleukin-2 binding +namespace: molecular_function +def: "Binding to interleukin-2." [GOC:jl] +synonym: "IL-2 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019977 +name: interleukin-21 binding +namespace: molecular_function +def: "Binding to interleukin-21." [GOC:jl] +synonym: "IL-21 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019978 +name: interleukin-3 binding +namespace: molecular_function +def: "Binding to interleukin-3." [GOC:jl] +synonym: "IL-3 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019979 +name: interleukin-4 binding +namespace: molecular_function +def: "Binding to interleukin-4." [GOC:jl] +synonym: "IL-4 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019980 +name: interleukin-5 binding +namespace: molecular_function +def: "Binding to interleukin-5." [GOC:jl] +synonym: "IL-5 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019981 +name: interleukin-6 binding +namespace: molecular_function +def: "Binding to interleukin-6." [GOC:jl] +synonym: "IL-6 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019982 +name: interleukin-7 binding +namespace: molecular_function +def: "Binding to interleukin-7." [GOC:jl] +synonym: "IL-7 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019983 +name: interleukin-9 binding +namespace: molecular_function +def: "Binding to interleukin-9." [GOC:jl] +synonym: "IL-9 binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0019985 +name: translesion synthesis +namespace: biological_process +def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] +synonym: "bypass DNA synthesis" EXACT [GOC:elh] +is_a: GO:0000731 ! DNA synthesis involved in DNA repair +is_a: GO:0006301 ! postreplication repair + +[Term] +id: GO:0019987 +name: obsolete negative regulation of anti-apoptosis +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] +comment: This term was made obsolete because it was ill-defined. +synonym: "down regulation of anti-apoptosis" EXACT [] +synonym: "down-regulation of anti-apoptosis" EXACT [] +synonym: "downregulation of anti-apoptosis" EXACT [] +synonym: "inhibition of anti-apoptosis" NARROW [] +synonym: "negative regulation of anti-apoptosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0019988 +name: charged-tRNA amino acid modification +namespace: biological_process +alt_id: GO:0030630 +def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg] +synonym: "charged tRNA amino acid modification" EXACT [] +synonym: "charged tRNA modification" EXACT [] +synonym: "charged-tRNA modification" RELATED [] +synonym: "pre-translational amino acid modification" EXACT [] +synonym: "pre-translational protein modification" EXACT [] +synonym: "pretranslation protein modification" EXACT [] +synonym: "pretranslational amino acid modification" EXACT [] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0019990 +name: pteridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] +synonym: "pteridine breakdown" EXACT [] +synonym: "pteridine catabolism" EXACT [] +synonym: "pteridine degradation" EXACT [] +is_a: GO:0019889 ! pteridine metabolic process +is_a: GO:0042560 ! pteridine-containing compound catabolic process + +[Term] +id: GO:0019991 +name: septate junction assembly +namespace: biological_process +def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] +is_a: GO:0120192 ! tight junction assembly +relationship: part_of GO:0043297 ! apical junction assembly + +[Term] +id: GO:0019992 +name: diacylglycerol binding +namespace: molecular_function +def: "Binding to a diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0020002 +name: host cell plasma membrane +namespace: cellular_component +def: "The plasma membrane surrounding a host cell." [GOC:mb] +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0020003 +name: symbiont-containing vacuole +namespace: cellular_component +def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb] +comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. +synonym: "bacterium-containing vacuole" NARROW [PMID:22042847] +synonym: "parasitophorous vacuole" EXACT [] +synonym: "pathogen-occupied vacuole" NARROW [PMID:24034612] +synonym: "Salmonella-containing vacuole" NARROW [PMID:10449405, PMID:15121880] +synonym: "SCV" EXACT [PMID:10449405, PMID:15121880] +is_a: GO:0033655 ! host cell cytoplasm part +is_a: GO:0065010 ! extracellular membrane-bounded organelle + +[Term] +id: GO:0020004 +name: symbiont-containing vacuolar space +namespace: cellular_component +def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb] +synonym: "parasitophorous vacuolar space" EXACT [] +synonym: "symbiont-containing vacuole space" RELATED [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0020003 ! symbiont-containing vacuole + +[Term] +id: GO:0020005 +name: symbiont-containing vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb] +synonym: "parasitophorous vacuolar membrane" EXACT [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0020003 ! symbiont-containing vacuole + +[Term] +id: GO:0020006 +name: symbiont-containing vacuolar membrane network +namespace: cellular_component +def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173] +synonym: "parasitophorous vacuolar membrane network" EXACT [] +synonym: "symbiont-containing vacuole membrane network" EXACT [] +synonym: "tubulovesicular network" NARROW [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane + +[Term] +id: GO:0020007 +name: apical complex +namespace: cellular_component +def: "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation." [GOC:giardia, GOC:mb, PMID:16518471] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0020008 +name: rhoptry +namespace: cellular_component +def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398] +synonym: "paired organelles" RELATED [] +synonym: "toxoneme" RELATED [] +xref: Wikipedia:Rhoptry +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020009 +name: microneme +namespace: cellular_component +def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218] +synonym: "sarconeme" RELATED [] +xref: Wikipedia:Microneme +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020010 +name: conoid +namespace: cellular_component +def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020011 +name: apicoplast +namespace: cellular_component +def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] +xref: Wikipedia:Apicoplast +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0020013 +name: modulation by symbiont of host erythrocyte aggregation +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024] +comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting. +synonym: "rosetting" EXACT [] +xref: Wikipedia:Rosetting +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0020014 +name: schizogony +namespace: biological_process +def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb] +xref: Wikipedia:Protozoal_merogony +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0020015 +name: glycosome +namespace: cellular_component +def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] +subset: goslim_pir +xref: Wikipedia:Glycosome +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0020016 +name: ciliary pocket +namespace: cellular_component +def: "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes." [GOC:cilia, GOC:mb] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. +synonym: "cilial pocket" EXACT [] +synonym: "cilium pocket" EXACT [] +synonym: "flagellar pocket" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0020018 +name: ciliary pocket membrane +namespace: cellular_component +def: "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket)." [GOC:cilia, GOC:mb] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. +synonym: "cilial pocket membrane" EXACT [] +synonym: "cilium pocket membrane" EXACT [] +synonym: "flagellar pocket membrane" EXACT [] +is_a: GO:0060170 ! ciliary membrane +relationship: part_of GO:0020016 ! ciliary pocket + +[Term] +id: GO:0020020 +name: food vacuole +namespace: cellular_component +alt_id: GO:0005772 +def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb] +synonym: "digestive vacuole" EXACT [] +is_a: GO:0032010 ! phagolysosome + +[Term] +id: GO:0020022 +name: acidocalcisome +namespace: cellular_component +def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] +subset: goslim_pir +synonym: "metachromatic granule" EXACT [PMID:15738951] +synonym: "polyphosphate vacuole" RELATED [PMID:15738951] +synonym: "volutin granule" EXACT [PMID:15738951] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0020023 +name: kinetoplast +namespace: cellular_component +def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] +xref: Wikipedia:Kinetoplast +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0020025 +name: subpellicular microtubule +namespace: cellular_component +def: "Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid." [GOC:mb, PMID:24800253] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020026 +name: merozoite dense granule +namespace: cellular_component +def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] +synonym: "dense body" RELATED [] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0020027 +name: hemoglobin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl] +synonym: "haemoglobin metabolic process" EXACT [] +synonym: "haemoglobin metabolism" EXACT [] +synonym: "hemoglobin metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0020028 +name: endocytic hemoglobin import into cell +namespace: biological_process +def: "The directed movement of hemoglobin into a cell by receptor-mediated endocytosis." [GOC:mb] +synonym: "endocytic hemoglobin import" RELATED [] +synonym: "haemoglobin uptake" EXACT [] +synonym: "hemoglobin uptake" EXACT [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0017038 ! protein import +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0020030 +name: infected host cell surface knob +namespace: cellular_component +def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0020031 +name: polar ring of apical complex +namespace: cellular_component +def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] +synonym: "anterior polar ring of apical complex" EXACT [] +synonym: "upper polar ring of apical complex" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020032 +name: basal ring of apical complex +namespace: cellular_component +def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] +synonym: "lower polar ring of apical complex" EXACT [] +synonym: "posterior polar ring of apical complex" EXACT [] +synonym: "preconoidal ring of apical complex" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0020033 +name: antigenic variation +namespace: biological_process +alt_id: GO:0020034 +def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb] +synonym: "surface antigen variation" NARROW [] +xref: Wikipedia:Antigenic_variation +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0020035 +name: cytoadherence to microvasculature, mediated by symbiont protein +namespace: biological_process +alt_id: GO:0043706 +def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb, PMID:10362584] +synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW [] +synonym: "heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein" NARROW [] +synonym: "parasite-protein-mediated cytoadherence to microvasculature" NARROW [] +synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD [] +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0020036 +name: Maurer's cleft +namespace: cellular_component +def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] +synonym: "Maurers cleft" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0020037 +name: heme binding +namespace: molecular_function +def: "Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:ai] +synonym: "haem binding" EXACT [] +is_a: GO:0046906 ! tetrapyrrole binding + +[Term] +id: GO:0020038 +name: subpellicular network +namespace: cellular_component +def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0020039 ! pellicle + +[Term] +id: GO:0020039 +name: pellicle +namespace: cellular_component +def: "The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0021501 +name: prechordal plate formation +namespace: biological_process +def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0021502 +name: neural fold elevation formation +namespace: biological_process +def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0001842 ! neural fold formation + +[Term] +id: GO:0021503 +name: neural fold bending +namespace: biological_process +def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0001842 ! neural fold formation + +[Term] +id: GO:0021504 +name: neural fold hinge point formation +namespace: biological_process +def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586] +synonym: "neural fold furrowing" NARROW [GOC:cls] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021503 ! neural fold bending + +[Term] +id: GO:0021505 +name: neural fold folding +namespace: biological_process +def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0021503 ! neural fold bending + +[Term] +id: GO:0021506 +name: anterior neuropore closure +namespace: biological_process +def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0021995 ! neuropore closure + +[Term] +id: GO:0021507 +name: posterior neuropore closure +namespace: biological_process +def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure +relationship: part_of GO:0021995 ! neuropore closure + +[Term] +id: GO:0021508 +name: floor plate formation +namespace: biological_process +def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007418 ! ventral midline development +relationship: part_of GO:0033505 ! floor plate morphogenesis + +[Term] +id: GO:0021509 +name: roof plate formation +namespace: biological_process +def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0001841 ! neural tube formation + +[Term] +id: GO:0021510 +name: spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021511 +name: spinal cord patterning +namespace: biological_process +def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021512 +name: spinal cord anterior/posterior patterning +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "spinal cord anterior-posterior patterning" EXACT [] +synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0021511 ! spinal cord patterning + +[Term] +id: GO:0021513 +name: spinal cord dorsal/ventral patterning +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "spinal cord dorsal-ventral patterning" EXACT [] +synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021511 ! spinal cord patterning + +[Term] +id: GO:0021514 +name: ventral spinal cord interneuron differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021517 ! ventral spinal cord development + +[Term] +id: GO:0021515 +name: cell differentiation in spinal cord +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021516 +name: dorsal spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11179871] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021517 +name: ventral spinal cord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021518 +name: spinal cord commissural neuron specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord + +[Term] +id: GO:0021519 +name: spinal cord association neuron specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021527 ! spinal cord association neuron differentiation + +[Term] +id: GO:0021520 +name: spinal cord motor neuron cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021521 +name: ventral spinal cord interneuron specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048665 ! neuron fate specification +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment + +[Term] +id: GO:0021522 +name: spinal cord motor neuron differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021517 ! ventral spinal cord development + +[Term] +id: GO:0021523 +name: somatic motor neuron differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021524 +name: visceral motor neuron differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021522 ! spinal cord motor neuron differentiation + +[Term] +id: GO:0021525 +name: lateral motor column neuron differentiation +namespace: biological_process +def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021522 ! spinal cord motor neuron differentiation +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021526 +name: medial motor column neuron differentiation +namespace: biological_process +def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021527 +name: spinal cord association neuron differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021516 ! dorsal spinal cord development + +[Term] +id: GO:0021528 +name: commissural neuron differentiation in spinal cord +namespace: biological_process +def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0021953 ! central nervous system neuron differentiation + +[Term] +id: GO:0021529 +name: spinal cord oligodendrocyte cell differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0021530 +name: spinal cord oligodendrocyte cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021778 ! oligodendrocyte cell fate specification +relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation + +[Term] +id: GO:0021531 +name: spinal cord radial glial cell differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16185248] +synonym: "radial glial cell differentiation in spinal cord" EXACT [] +is_a: GO:0021515 ! cell differentiation in spinal cord +is_a: GO:0060019 ! radial glial cell differentiation + +[Term] +id: GO:0021532 +name: neural tube patterning +namespace: biological_process +def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0021533 +name: cell differentiation in hindbrain +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021534 +name: cell proliferation in hindbrain +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021535 +name: cell migration in hindbrain +namespace: biological_process +def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021536 +name: diencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021537 +name: telencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021538 +name: epithalamus development +namespace: biological_process +def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021539 +name: subthalamus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "ventral thalamus development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021540 +name: corpus callosum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis +relationship: part_of GO:0022038 ! corpus callosum development + +[Term] +id: GO:0021541 +name: ammon gyrus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "Ammon's horn development" RELATED [GOC:cls] +synonym: "cornu ammonis development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021766 ! hippocampus development + +[Term] +id: GO:0021542 +name: dentate gyrus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021766 ! hippocampus development + +[Term] +id: GO:0021543 +name: pallium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021544 +name: subpallium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021545 +name: cranial nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0021675 ! nerve development + +[Term] +id: GO:0021546 +name: rhombomere development +namespace: biological_process +def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021547 +name: midbrain-hindbrain boundary initiation +namespace: biological_process +def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:15541513] +synonym: "isthmus biosynthesis" RELATED [GOC:cls] +synonym: "isthmus formation" RELATED [GOC:cls] +synonym: "MHB biosynthesis" EXACT [GOC:cls] +synonym: "MHB formation" EXACT [GOC:cls] +synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] +synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] +is_a: GO:0003002 ! regionalization +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021548 +name: pons development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0022037 ! metencephalon development + +[Term] +id: GO:0021549 +name: cerebellum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0022037 ! metencephalon development + +[Term] +id: GO:0021550 +name: medulla oblongata development +namespace: biological_process +def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla development" RELATED [GOC:cls] +synonym: "myelencephalon development" RELATED [GOC:cls] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021551 +name: central nervous system morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021552 +name: midbrain-hindbrain boundary structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +synonym: "isthmus structural organization" RELATED [GOC:cls] +synonym: "MHB structural organization" EXACT [GOC:cls] +synonym: "midbrain-hindbrain boundary structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis + +[Term] +id: GO:0021553 +name: olfactory nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN 1 development" RELATED [GOC:cls] +synonym: "cranial nerve 1 development" EXACT [GOC:cls] +synonym: "cranial nerve I development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021554 +name: optic nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN II development" RELATED [GOC:cls] +synonym: "cranial nerve 2 development" EXACT [GOC:cls] +synonym: "cranial nerve II development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021555 +name: midbrain-hindbrain boundary morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +synonym: "isthmus morphogenesis" EXACT [GOC:cls] +synonym: "MHB morphogenesis" EXACT [GOC:cls] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021556 +name: central nervous system formation +namespace: biological_process +def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021551 ! central nervous system morphogenesis + +[Term] +id: GO:0021557 +name: oculomotor nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN III development" RELATED [GOC:cls] +synonym: "cranial nerve 3 development" EXACT [GOC:cls] +synonym: "cranial nerve III development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development + +[Term] +id: GO:0021558 +name: trochlear nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IV development" RELATED [GOC:cls] +synonym: "cranial nerve 4 development" EXACT [GOC:cls] +synonym: "cranial nerve IV development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021559 +name: trigeminal nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V development" RELATED [GOC:cls] +synonym: "cranial nerve 5 development" EXACT [GOC:cls] +synonym: "cranial nerve V development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021560 +name: abducens nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VI development" RELATED [GOC:cls] +synonym: "cranial nerve 6 development" EXACT [GOC:cls] +synonym: "cranial nerve VI development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021561 +name: facial nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII development" RELATED [GOC:cls] +synonym: "cranial nerve 7 development" EXACT [GOC:cls] +synonym: "cranial nerve VII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development + +[Term] +id: GO:0021562 +name: vestibulocochlear nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "acoustic nerve development" EXACT [PMID:11533729] +synonym: "CN VIII development" EXACT [GOC:cls] +synonym: "cranial nerve 8 development" EXACT [GOC:cls] +synonym: "cranial nerve VIII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021563 +name: glossopharyngeal nerve development +namespace: biological_process +def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX development" RELATED [GOC:cls] +synonym: "cranial nerve 9 development" EXACT [GOC:cls] +synonym: "cranial nerve IX development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021564 +name: vagus nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X development" RELATED [GOC:cls] +synonym: "cranial nerve 10 development" RELATED [GOC:cls] +synonym: "cranial nerve X development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development + +[Term] +id: GO:0021565 +name: accessory nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XI development" RELATED [GOC:cls] +synonym: "cranial nerve 11 development" RELATED [GOC:cls] +synonym: "cranial nerve XI development" EXACT [GOC:cls] +synonym: "spinal accessory nerve development" EXACT [PMID:11533729] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021566 +name: hypoglossal nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII development" RELATED [GOC:cls] +synonym: "cranial nerve 12 development" RELATED [GOC:cls] +synonym: "cranial nerve XII development" EXACT [GOC:cls] +is_a: GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021567 +name: rhombomere 1 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021568 +name: rhombomere 2 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021569 +name: rhombomere 3 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021570 +name: rhombomere 4 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021571 +name: rhombomere 5 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021572 +name: rhombomere 6 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021573 +name: rhombomere 7 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021574 +name: rhombomere 8 development +namespace: biological_process +def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021546 ! rhombomere development + +[Term] +id: GO:0021575 +name: hindbrain morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "rhombencephalon morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021576 +name: hindbrain formation +namespace: biological_process +def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021577 +name: hindbrain structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "hindbrain structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021578 +name: hindbrain maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021626 ! central nervous system maturation +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021579 +name: medulla oblongata morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla morphogenesis" RELATED [] +synonym: "myelencephalon morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021550 ! medulla oblongata development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021580 +name: medulla oblongata formation +namespace: biological_process +def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla biosynthesis" RELATED [] +synonym: "medulla formation" RELATED [] +synonym: "myelencephalon biosynthesis" RELATED [] +synonym: "myelencephalon formation" RELATED [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis + +[Term] +id: GO:0021581 +name: medulla oblongata structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla oblongata structural organisation" EXACT [GOC:mah] +synonym: "medulla structural maturation" RELATED [] +synonym: "myelencephalon structural maturation" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis + +[Term] +id: GO:0021582 +name: medulla oblongata maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "medulla maturation" RELATED [] +synonym: "myelencephalon maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021550 ! medulla oblongata development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021583 +name: pons morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021584 +name: pons formation +namespace: biological_process +def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021583 ! pons morphogenesis + +[Term] +id: GO:0021585 +name: pons structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "pons structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021583 ! pons morphogenesis + +[Term] +id: GO:0021586 +name: pons maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021587 +name: cerebellum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021549 ! cerebellum development +relationship: part_of GO:0021575 ! hindbrain morphogenesis + +[Term] +id: GO:0021588 +name: cerebellum formation +namespace: biological_process +def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021576 ! hindbrain formation +relationship: part_of GO:0021587 ! cerebellum morphogenesis + +[Term] +id: GO:0021589 +name: cerebellum structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cerebellum structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021577 ! hindbrain structural organization +relationship: part_of GO:0021587 ! cerebellum morphogenesis + +[Term] +id: GO:0021590 +name: cerebellum maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021549 ! cerebellum development +relationship: part_of GO:0021578 ! hindbrain maturation + +[Term] +id: GO:0021591 +name: ventricular system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0021592 +name: fourth ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021591 ! ventricular system development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0021593 +name: rhombomere morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0021594 +name: rhombomere formation +namespace: biological_process +def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021593 ! rhombomere morphogenesis + +[Term] +id: GO:0021595 +name: rhombomere structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "rhombomere structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021593 ! rhombomere morphogenesis + +[Term] +id: GO:0021597 +name: central nervous system structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] +synonym: "central nervous system structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021551 ! central nervous system morphogenesis + +[Term] +id: GO:0021598 +name: abducens nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VI development" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021560 ! abducens nerve development + +[Term] +id: GO:0021599 +name: abducens nerve formation +namespace: biological_process +def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VI biosynthesis" RELATED [] +synonym: "CN VI formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021598 ! abducens nerve morphogenesis + +[Term] +id: GO:0021600 +name: abducens nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "abducens nerve structural organisation" EXACT [GOC:mah] +synonym: "CN VI structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021598 ! abducens nerve morphogenesis + +[Term] +id: GO:0021601 +name: abducens nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VI maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021560 ! abducens nerve development + +[Term] +id: GO:0021602 +name: cranial nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021603 +name: cranial nerve formation +namespace: biological_process +def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021602 ! cranial nerve morphogenesis + +[Term] +id: GO:0021604 +name: cranial nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cranial nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021602 ! cranial nerve morphogenesis + +[Term] +id: GO:0021605 +name: cranial nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0021682 ! nerve maturation +relationship: part_of GO:0021545 ! cranial nerve development + +[Term] +id: GO:0021606 +name: accessory nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XI maturation" RELATED [] +synonym: "spinal accessory nerve maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021565 ! accessory nerve development + +[Term] +id: GO:0021607 +name: accessory nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XI morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021565 ! accessory nerve development + +[Term] +id: GO:0021608 +name: accessory nerve formation +namespace: biological_process +def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XI biosynthesis" RELATED [] +synonym: "CN XI formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021607 ! accessory nerve morphogenesis + +[Term] +id: GO:0021609 +name: accessory nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "accessory nerve structural organisation" EXACT [GOC:mah] +synonym: "CN XI structural organization" RELATED [] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021607 ! accessory nerve morphogenesis + +[Term] +id: GO:0021610 +name: facial nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021561 ! facial nerve development + +[Term] +id: GO:0021611 +name: facial nerve formation +namespace: biological_process +def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII biosynthesis" RELATED [] +synonym: "CN VII formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021610 ! facial nerve morphogenesis + +[Term] +id: GO:0021612 +name: facial nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII structural organization" RELATED [] +synonym: "facial nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021610 ! facial nerve morphogenesis + +[Term] +id: GO:0021613 +name: facial nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021561 ! facial nerve development + +[Term] +id: GO:0021614 +name: glossopharyngeal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021563 ! glossopharyngeal nerve development + +[Term] +id: GO:0021615 +name: glossopharyngeal nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021563 ! glossopharyngeal nerve development + +[Term] +id: GO:0021616 +name: glossopharyngeal nerve formation +namespace: biological_process +def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX biosynthesis" RELATED [] +synonym: "CN IX formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis + +[Term] +id: GO:0021617 +name: glossopharyngeal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IX structural organization" RELATED [] +synonym: "glossopharyngeal nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis + +[Term] +id: GO:0021618 +name: hypoglossal nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021566 ! hypoglossal nerve development + +[Term] +id: GO:0021619 +name: hypoglossal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021566 ! hypoglossal nerve development + +[Term] +id: GO:0021620 +name: hypoglossal nerve formation +namespace: biological_process +def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII biosynthesis" RELATED [] +synonym: "CN XII formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis + +[Term] +id: GO:0021621 +name: hypoglossal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN XII structural organization" RELATED [] +synonym: "hypoglossal nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis + +[Term] +id: GO:0021622 +name: oculomotor nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN III morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021557 ! oculomotor nerve development + +[Term] +id: GO:0021623 +name: oculomotor nerve formation +namespace: biological_process +def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN III biosynthesis" RELATED [] +synonym: "CN III formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis + +[Term] +id: GO:0021624 +name: oculomotor nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN III structural organization" RELATED [] +synonym: "oculomotor nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis + +[Term] +id: GO:0021625 +name: oculomotor nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN III maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021557 ! oculomotor nerve development + +[Term] +id: GO:0021626 +name: central nervous system maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0582227089] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021627 +name: olfactory nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN I morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021553 ! olfactory nerve development + +[Term] +id: GO:0021628 +name: olfactory nerve formation +namespace: biological_process +def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN I biosynthesis" RELATED [] +synonym: "CN I formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021627 ! olfactory nerve morphogenesis + +[Term] +id: GO:0021629 +name: olfactory nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN I structural organization" RELATED [] +synonym: "olfactory nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021627 ! olfactory nerve morphogenesis + +[Term] +id: GO:0021630 +name: olfactory nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "CN I maturation" EXACT [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021553 ! olfactory nerve development + +[Term] +id: GO:0021631 +name: optic nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN II morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021554 ! optic nerve development + +[Term] +id: GO:0021632 +name: optic nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN II maturation" EXACT [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021554 ! optic nerve development + +[Term] +id: GO:0021633 +name: optic nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN II structural organization" RELATED [] +synonym: "optic nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021631 ! optic nerve morphogenesis + +[Term] +id: GO:0021634 +name: optic nerve formation +namespace: biological_process +def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN II biosynthesis" RELATED [] +synonym: "CN II formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021631 ! optic nerve morphogenesis + +[Term] +id: GO:0021635 +name: trigeminal nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021559 ! trigeminal nerve development + +[Term] +id: GO:0021636 +name: trigeminal nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021559 ! trigeminal nerve development + +[Term] +id: GO:0021637 +name: trigeminal nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V structural organization" RELATED [] +synonym: "trigeminal nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis + +[Term] +id: GO:0021638 +name: trigeminal nerve formation +namespace: biological_process +def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN V biosynthesis" RELATED [] +synonym: "CN V formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis + +[Term] +id: GO:0021639 +name: trochlear nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CH IV morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021558 ! trochlear nerve development + +[Term] +id: GO:0021640 +name: trochlear nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IV maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021558 ! trochlear nerve development + +[Term] +id: GO:0021641 +name: trochlear nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IV structural organization" RELATED [] +synonym: "trochlear nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021639 ! trochlear nerve morphogenesis + +[Term] +id: GO:0021642 +name: trochlear nerve formation +namespace: biological_process +def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN IV biosynthesis" RELATED [] +synonym: "CN IV formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021639 ! trochlear nerve morphogenesis + +[Term] +id: GO:0021643 +name: vagus nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021564 ! vagus nerve development + +[Term] +id: GO:0021644 +name: vagus nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021564 ! vagus nerve development + +[Term] +id: GO:0021645 +name: vagus nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X structural organization" RELATED [] +synonym: "vagus nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021644 ! vagus nerve morphogenesis + +[Term] +id: GO:0021646 +name: vagus nerve formation +namespace: biological_process +def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN X biosynthesis" RELATED [] +synonym: "CN X formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021644 ! vagus nerve morphogenesis + +[Term] +id: GO:0021647 +name: vestibulocochlear nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "auditory nerve maturation" RELATED [] +synonym: "CN VIII maturation" RELATED [] +is_a: GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0021562 ! vestibulocochlear nerve development + +[Term] +id: GO:0021648 +name: vestibulocochlear nerve morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VIII morphogenesis" RELATED [] +is_a: GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0021562 ! vestibulocochlear nerve development + +[Term] +id: GO:0021649 +name: vestibulocochlear nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII structural organization" RELATED [] +synonym: "vestibulocochlear nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis + +[Term] +id: GO:0021650 +name: vestibulocochlear nerve formation +namespace: biological_process +def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "CN VII formation" RELATED [] +is_a: GO:0021603 ! cranial nerve formation +relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis + +[Term] +id: GO:0021651 +name: rhombomere 1 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021567 ! rhombomere 1 development + +[Term] +id: GO:0021652 +name: rhombomere 1 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis + +[Term] +id: GO:0021653 +name: rhombomere 1 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 1 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis + +[Term] +id: GO:0021654 +name: rhombomere boundary formation +namespace: biological_process +def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0021594 ! rhombomere formation + +[Term] +id: GO:0021655 +name: rhombomere 2 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021568 ! rhombomere 2 development + +[Term] +id: GO:0021656 +name: rhombomere 2 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 2 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis + +[Term] +id: GO:0021657 +name: rhombomere 2 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis + +[Term] +id: GO:0021658 +name: rhombomere 3 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021569 ! rhombomere 3 development + +[Term] +id: GO:0021659 +name: rhombomere 3 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 3 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis + +[Term] +id: GO:0021660 +name: rhombomere 3 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis + +[Term] +id: GO:0021661 +name: rhombomere 4 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021570 ! rhombomere 4 development + +[Term] +id: GO:0021662 +name: rhombomere 4 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 4 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis + +[Term] +id: GO:0021663 +name: rhombomere 4 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis + +[Term] +id: GO:0021664 +name: rhombomere 5 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021571 ! rhombomere 5 development + +[Term] +id: GO:0021665 +name: rhombomere 5 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 5 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis + +[Term] +id: GO:0021666 +name: rhombomere 5 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis + +[Term] +id: GO:0021667 +name: rhombomere 6 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021572 ! rhombomere 6 development + +[Term] +id: GO:0021668 +name: rhombomere 6 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 6 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis + +[Term] +id: GO:0021669 +name: rhombomere 6 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis + +[Term] +id: GO:0021670 +name: lateral ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development +relationship: part_of GO:0021591 ! ventricular system development + +[Term] +id: GO:0021671 +name: rhombomere 7 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021573 ! rhombomere 7 development + +[Term] +id: GO:0021672 +name: rhombomere 7 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 7 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis + +[Term] +id: GO:0021673 +name: rhombomere 7 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis + +[Term] +id: GO:0021674 +name: rhombomere 8 morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021593 ! rhombomere morphogenesis +relationship: part_of GO:0021574 ! rhombomere 8 development + +[Term] +id: GO:0021675 +name: nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0021676 +name: rhombomere 8 structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rhombomere 8 structural organisation" EXACT [GOC:mah] +is_a: GO:0021595 ! rhombomere structural organization +relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis + +[Term] +id: GO:0021677 +name: rhombomere 8 formation +namespace: biological_process +def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021594 ! rhombomere formation +relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis + +[Term] +id: GO:0021678 +name: third ventricle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021591 ! ventricular system development + +[Term] +id: GO:0021679 +name: cerebellar molecular layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021680 +name: cerebellar Purkinje cell layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021681 +name: cerebellar granular layer development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021682 +name: nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021675 ! nerve development + +[Term] +id: GO:0021683 +name: cerebellar granular layer morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021681 ! cerebellar granular layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021684 +name: cerebellar granular layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021685 +name: cerebellar granular layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cerebellar granular layer structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021686 +name: cerebellar granular layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021681 ! cerebellar granular layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021687 +name: cerebellar molecular layer morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021679 ! cerebellar molecular layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021688 +name: cerebellar molecular layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021689 +name: cerebellar molecular layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cerebellar molecular layer structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021690 +name: cerebellar molecular layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021679 ! cerebellar molecular layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021691 +name: cerebellar Purkinje cell layer maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development +relationship: part_of GO:0021699 ! cerebellar cortex maturation + +[Term] +id: GO:0021692 +name: cerebellar Purkinje cell layer morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021693 +name: cerebellar Purkinje cell layer structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cerebellar Purkinje cell layer structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis +relationship: part_of GO:0021698 ! cerebellar cortex structural organization + +[Term] +id: GO:0021694 +name: cerebellar Purkinje cell layer formation +namespace: biological_process +def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021695 +name: cerebellar cortex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021696 +name: cerebellar cortex morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021587 ! cerebellum morphogenesis +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021697 +name: cerebellar cortex formation +namespace: biological_process +def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021698 +name: cerebellar cortex structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "cerebellar cortex structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis + +[Term] +id: GO:0021699 +name: cerebellar cortex maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021590 ! cerebellum maturation +relationship: part_of GO:0021695 ! cerebellar cortex development + +[Term] +id: GO:0021700 +name: developmental maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +subset: goslim_chembl +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0021701 +name: cerebellar Golgi cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +is_a: GO:0097154 ! GABAergic neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021702 +name: cerebellar Purkinje cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation + +[Term] +id: GO:0021703 +name: locus ceruleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "locus caeruleus development" EXACT [] +synonym: "locus coeruleus development" EXACT [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021704 +name: locus ceruleus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021583 ! pons morphogenesis +relationship: part_of GO:0021703 ! locus ceruleus development + +[Term] +id: GO:0021705 +name: locus ceruleus formation +namespace: biological_process +def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021584 ! pons formation +relationship: part_of GO:0021704 ! locus ceruleus morphogenesis + +[Term] +id: GO:0021706 +name: locus ceruleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021703 ! locus ceruleus development + +[Term] +id: GO:0021707 +name: cerebellar granule cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021708 +name: Lugaro cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +is_a: GO:0097154 ! GABAergic neuron differentiation +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021709 +name: cerebellar basket cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021688 ! cerebellar molecular layer formation + +[Term] +id: GO:0021710 +name: cerebellar stellate cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021688 ! cerebellar molecular layer formation + +[Term] +id: GO:0021711 +name: cerebellar unipolar brush cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021684 ! cerebellar granular layer formation + +[Term] +id: GO:0021712 +name: candelabrum cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation + +[Term] +id: GO:0021713 +name: inferior olivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "inferior olive development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021714 +name: inferior olivary nucleus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "inferior olive morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021579 ! medulla oblongata morphogenesis +relationship: part_of GO:0021713 ! inferior olivary nucleus development + +[Term] +id: GO:0021715 +name: inferior olivary nucleus formation +namespace: biological_process +def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "inferior olive biosynthesis" RELATED [] +synonym: "inferior olive formation" RELATED [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021580 ! medulla oblongata formation +relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis + +[Term] +id: GO:0021716 +name: inferior olivary nucleus structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "inferior olivary nucleus structural organisation" EXACT [GOC:mah] +synonym: "inferior olive structural organization" RELATED [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021581 ! medulla oblongata structural organization +relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis + +[Term] +id: GO:0021717 +name: inferior olivary nucleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "inferior olive maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021582 ! medulla oblongata maturation +relationship: part_of GO:0021713 ! inferior olivary nucleus development + +[Term] +id: GO:0021718 +name: superior olivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "superior olive development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021719 +name: superior olivary nucleus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "superior olive morphogenesis" RELATED [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021583 ! pons morphogenesis +relationship: part_of GO:0021718 ! superior olivary nucleus development + +[Term] +id: GO:0021720 +name: superior olivary nucleus formation +namespace: biological_process +def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021584 ! pons formation +relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis + +[Term] +id: GO:0021721 +name: superior olivary nucleus structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "superior olivary nucleus structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0021585 ! pons structural organization +relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis + +[Term] +id: GO:0021722 +name: superior olivary nucleus maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +synonym: "superior olive maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021586 ! pons maturation +relationship: part_of GO:0021718 ! superior olivary nucleus development + +[Term] +id: GO:0021723 +name: medullary reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, http://www.brainspan.org, Wikipedia:Rhombencephalon] +synonym: "rhombencephalic reticular formation development" BROAD [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021724 +name: inferior raphe nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000366] +synonym: "inferior central nucleus development" BROAD [] +synonym: "posterior raphe nucleus development" BROAD [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021725 +name: superior raphe nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, PMID:19003874, ZFA:0000440] +synonym: "anterior raphe nucleus development" BROAD [] +synonym: "superior central nucleus development" BROAD [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021726 +name: lateral reticular nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021727 +name: intermediate reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +synonym: "intermediate reticular nucleus development" EXACT [http://www.brainspan.org] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021728 +name: inferior reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021729 +name: superior reticular formation development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021723 ! medullary reticular formation development + +[Term] +id: GO:0021730 +name: trigeminal sensory nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +comment: Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0021731 +name: trigeminal motor nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021732 +name: midbrain-hindbrain boundary maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +synonym: "isthmus maturation" RELATED [] +synonym: "MHB maturation" RELATED [] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development + +[Term] +id: GO:0021735 +name: dentate nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021736 +name: globose nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021737 +name: emboliform nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021738 +name: fastigial nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0021739 +name: mesencephalic trigeminal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021740 +name: principal sensory nucleus of trigeminal nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +comment: Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. +synonym: "pontine nucleus development" BROAD [GOC:dph] +is_a: GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021741 +name: spinal trigeminal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021730 ! trigeminal sensory nucleus development + +[Term] +id: GO:0021742 +name: abducens nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021743 +name: hypoglossal nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021744 +name: dorsal motor nucleus of vagus nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021745 +name: nucleus ambiguus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021746 +name: solitary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021747 +name: cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021748 +name: dorsal cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021747 ! cochlear nucleus development + +[Term] +id: GO:0021749 +name: ventral cochlear nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021747 ! cochlear nucleus development + +[Term] +id: GO:0021750 +name: vestibular nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, PMID:16221589] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0021751 +name: salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021752 +name: inferior salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021751 ! salivary nucleus development + +[Term] +id: GO:0021753 +name: superior salivary nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021751 ! salivary nucleus development + +[Term] +id: GO:0021754 +name: facial nucleus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021548 ! pons development + +[Term] +id: GO:0021755 +name: eurydendroid cell differentiation +namespace: biological_process +def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15892096] +is_a: GO:0021533 ! cell differentiation in hindbrain +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021697 ! cerebellar cortex formation + +[Term] +id: GO:0021756 +name: striatum development +namespace: biological_process +def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "neostriatum development" EXACT [] +synonym: "striate nucleus development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0021757 +name: caudate nucleus development +namespace: biological_process +def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021758 +name: putamen development +namespace: biological_process +def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021759 +name: globus pallidus development +namespace: biological_process +def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "pallidum development" EXACT [PMID:16271465] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021761 +name: limbic system development +namespace: biological_process +def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048731 ! system development +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021762 +name: substantia nigra development +namespace: biological_process +def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343, ISBN:0878937420] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:0021763 +name: subthalamic nucleus development +namespace: biological_process +def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "corpus luysi development" RELATED [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021539 ! subthalamus development + +[Term] +id: GO:0021764 +name: amygdala development +namespace: biological_process +def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021765 +name: cingulate gyrus development +namespace: biological_process +def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021766 +name: hippocampus development +namespace: biological_process +def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421] +synonym: "hippocampal formation development" EXACT [ABA:HPF] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021543 ! pallium development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021767 +name: mammillary body development +namespace: biological_process +def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021768 +name: nucleus accumbens development +namespace: biological_process +def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "accumbens nucleus development" EXACT [GOC:dgh] +synonym: "ventral striatum development" BROAD [] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021756 ! striatum development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021769 +name: orbitofrontal cortex development +namespace: biological_process +def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021770 +name: parahippocampal gyrus development +namespace: biological_process +def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "hippocampal gyrus development" EXACT [GOC:dgh] +xref: Wikipedia:parahippocampal_gyrus +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021771 +name: lateral geniculate nucleus development +namespace: biological_process +def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "LGN development" EXACT [GOC:dgh] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021794 ! thalamus development + +[Term] +id: GO:0021772 +name: olfactory bulb development +namespace: biological_process +def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021988 ! olfactory lobe development + +[Term] +id: GO:0021773 +name: striatal medium spiny neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741] +synonym: "striatal MSN differentiation" EXACT [PMID:25804741] +is_a: GO:0021879 ! forebrain neuron differentiation +relationship: part_of GO:0021756 ! striatum development + +[Term] +id: GO:0021774 +name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:sdb_2009, GOC:tb, PMID:11262869] +synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] +is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning +relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification + +[Term] +id: GO:0021775 +name: smoothened signaling pathway involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] +is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification + +[Term] +id: GO:0021776 +name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15936325] +synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT [] +is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification + +[Term] +id: GO:0021777 +name: obsolete BMP signaling pathway involved in spinal cord association neuron specification +namespace: biological_process +def: "OBSOLETE. A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT [] +synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [] +synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [] +is_obsolete: true + +[Term] +id: GO:0021778 +name: oligodendrocyte cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021780 ! glial cell fate specification +relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment + +[Term] +id: GO:0021779 +name: oligodendrocyte cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021781 ! glial cell fate commitment +is_a: GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0021780 +name: glial cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0021781 ! glial cell fate commitment + +[Term] +id: GO:0021781 +name: glial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0021782 +name: glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0021783 +name: preganglionic parasympathetic fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007417 ! central nervous system development +relationship: part_of GO:0048486 ! parasympathetic nervous system development + +[Term] +id: GO:0021784 +name: postganglionic parasympathetic fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048483 ! autonomic nervous system development +relationship: part_of GO:0007422 ! peripheral nervous system development +relationship: part_of GO:0048486 ! parasympathetic nervous system development + +[Term] +id: GO:0021785 +name: branchiomotor neuron axon guidance +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "BMN axon guidance" EXACT [PMID:14699587] +synonym: "branchial motor axon guidance" EXACT [PMID:14699587] +synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587] +is_a: GO:0008045 ! motor neuron axon guidance + +[Term] +id: GO:0021786 +name: branchiomotor neuron axon guidance in neural tube +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +is_a: GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021787 +name: chemorepulsion of branchiomotor neuron axon in neural tube +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] +is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube +is_a: GO:0021793 ! chemorepulsion of branchiomotor axon + +[Term] +id: GO:0021788 +name: chemoattraction of branchiomotor neuron axon in neural tube +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] +is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube +is_a: GO:0021792 ! chemoattraction of branchiomotor axon + +[Term] +id: GO:0021789 +name: branchiomotor neuron axon guidance in branchial arch mesenchyme +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +is_a: GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021790 +name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] +is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme +is_a: GO:0021793 ! chemorepulsion of branchiomotor axon + +[Term] +id: GO:0021791 +name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] +is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme +is_a: GO:0021792 ! chemoattraction of branchiomotor axon + +[Term] +id: GO:0021792 +name: chemoattraction of branchiomotor axon +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah] +is_a: GO:0061642 ! chemoattraction of axon +relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021793 +name: chemorepulsion of branchiomotor axon +namespace: biological_process +def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:14699587] +synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah] +is_a: GO:0061643 ! chemorepulsion of axon +relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance + +[Term] +id: GO:0021794 +name: thalamus development +namespace: biological_process +def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0021795 +name: cerebral cortex cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021987 ! cerebral cortex development + +[Term] +id: GO:0021796 +name: cerebral cortex regionalization +namespace: biological_process +def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "cerebral cortex arealization" EXACT [] +synonym: "cerebral cortex pattern biosynthesis" EXACT [] +synonym: "cerebral cortex pattern formation" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021978 ! telencephalon regionalization +relationship: part_of GO:0021987 ! cerebral cortex development + +[Term] +id: GO:0021797 +name: forebrain anterior/posterior pattern specification +namespace: biological_process +def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "forebrain anterior-posterior pattern specification" EXACT [] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021798 +name: forebrain dorsal/ventral pattern formation +namespace: biological_process +def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah] +synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021799 +name: cerebral cortex radially oriented cell migration +namespace: biological_process +def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021795 ! cerebral cortex cell migration + +[Term] +id: GO:0021800 +name: cerebral cortex tangential migration +namespace: biological_process +def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021795 ! cerebral cortex cell migration + +[Term] +id: GO:0021801 +name: cerebral cortex radial glia-guided migration +namespace: biological_process +def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cerebral cortex radial glia guided migration" EXACT [] +synonym: "cerebral cortex radial glia-dependent cell migration" EXACT [] +synonym: "glial-guided locomotion" RELATED [PMID:12626695] +is_a: GO:0021799 ! cerebral cortex radially oriented cell migration +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0021802 +name: somal translocation +namespace: biological_process +def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695] +is_a: GO:0021799 ! cerebral cortex radially oriented cell migration + +[Term] +id: GO:0021803 +name: extension of leading cell process to pial surface +namespace: biological_process +def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021804 +name: negative regulation of cell adhesion in ventricular zone +namespace: biological_process +def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "down regulation of cell adhesion in ventricular zone" EXACT [] +synonym: "down-regulation of cell adhesion in ventricular zone" EXACT [] +synonym: "downregulation of cell adhesion in ventricular zone" EXACT [] +synonym: "inhibition of cell adhesion in ventricular zone" NARROW [] +is_a: GO:0007162 ! negative regulation of cell adhesion +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021805 +name: cell movement involved in somal translocation +namespace: biological_process +def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048870 ! cell motility +relationship: part_of GO:0021802 ! somal translocation + +[Term] +id: GO:0021806 +name: initiation of movement involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021807 +name: motogenic signaling initiating cell movement in cerebral cortex +namespace: biological_process +def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0023052 ! signaling +relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021808 +name: cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration +namespace: biological_process +def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021809 +name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex + +[Term] +id: GO:0021810 +name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex + +[Term] +id: GO:0021811 +name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio] +synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [] +is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex + +[Term] +id: GO:0021812 +name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration + +[Term] +id: GO:0021813 +name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021814 +name: cell motility involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] +is_a: GO:0048870 ! cell motility +relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration + +[Term] +id: GO:0021815 +name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021816 +name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration +is_a: GO:0031269 ! pseudopodium assembly + +[Term] +id: GO:0021817 +name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695] +synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] +is_a: GO:0030473 ! nuclear migration along microtubule +relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021818 +name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0030036 ! actin cytoskeleton organization +relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration + +[Term] +id: GO:0021819 +name: layer formation in cerebral cortex +namespace: biological_process +def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "cerebral cortex lamination" RELATED [PMID:12626695] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021801 ! cerebral cortex radial glia-guided migration + +[Term] +id: GO:0021820 +name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration" EXACT [GOC:mah] +synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0021819 ! layer formation in cerebral cortex + +[Term] +id: GO:0021821 +name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination +namespace: biological_process +def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] +synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +relationship: part_of GO:0021819 ! layer formation in cerebral cortex + +[Term] +id: GO:0021822 +name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration +namespace: biological_process +def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695] +synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] +synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] +synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] +synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] +is_a: GO:1903976 ! negative regulation of glial cell migration +relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration +relationship: part_of GO:0021819 ! layer formation in cerebral cortex + +[Term] +id: GO:0021823 +name: cerebral cortex tangential migration using cell-cell interactions +namespace: biological_process +def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "chain migration" RELATED [PMID:12626695] +is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration + +[Term] +id: GO:0021824 +name: cerebral cortex tangential migration using cell-axon interactions +namespace: biological_process +def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration + +[Term] +id: GO:0021825 +name: substrate-dependent cerebral cortex tangential migration +namespace: biological_process +def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0006929 ! substrate-dependent cell migration +is_a: GO:0021800 ! cerebral cortex tangential migration + +[Term] +id: GO:0021826 +name: substrate-independent telencephalic tangential migration +namespace: biological_process +def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0022029 ! telencephalon cell migration + +[Term] +id: GO:0021827 +name: postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions +is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb +relationship: part_of GO:0021891 ! olfactory bulb interneuron development + +[Term] +id: GO:0021828 +name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus +namespace: biological_process +alt_id: GO:0021857 +def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "gonadotropin-releasing hormone neuronal migration to the hypothalamus" EXACT [GOC:dph] +is_a: GO:0001764 ! neuron migration +is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions +relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development + +[Term] +id: GO:0021829 +name: oligodendrocyte cell migration from the subpallium to the cortex +namespace: biological_process +def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021826 ! substrate-independent telencephalic tangential migration +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0021830 +name: interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021831 +name: embryonic olfactory bulb interneuron precursor migration +namespace: biological_process +def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration +is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb +relationship: part_of GO:0021891 ! olfactory bulb interneuron development + +[Term] +id: GO:0021832 +name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions +namespace: biological_process +def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions + +[Term] +id: GO:0021833 +name: cell-matrix adhesion involved in tangential migration using cell-cell interactions +namespace: biological_process +def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:12626695] +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions + +[Term] +id: GO:0021834 +name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration +namespace: biological_process +def: "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration + +[Term] +id: GO:0021835 +name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration +namespace: biological_process +def: "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration + +[Term] +id: GO:0021836 +name: chemorepulsion involved in postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration + +[Term] +id: GO:0021837 +name: motogenic signaling involved in postnatal olfactory bulb interneuron migration +namespace: biological_process +def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0023052 ! signaling +relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration + +[Term] +id: GO:0021838 +name: motogenic signaling involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0023052 ! signaling +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021839 +name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021840 +name: directional guidance of interneurons involved in migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0030334 ! regulation of cell migration +relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex + +[Term] +id: GO:0021841 +name: chemoattraction involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex + +[Term] +id: GO:0021842 +name: chemorepulsion involved in interneuron migration from the subpallium to the cortex +namespace: biological_process +def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex + +[Term] +id: GO:0021843 +name: substrate-independent telencephalic tangential interneuron migration +namespace: biological_process +def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021826 ! substrate-independent telencephalic tangential migration + +[Term] +id: GO:0021844 +name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration +namespace: biological_process +def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0042330 ! taxis +relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021845 +name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration +namespace: biological_process +def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0030334 ! regulation of cell migration +relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration + +[Term] +id: GO:0021846 +name: cell proliferation in forebrain +namespace: biological_process +def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021847 +name: ventricular zone neuroblast division +namespace: biological_process +def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "neuroblast division in ventricular zone" EXACT [] +is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division +is_a: GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021848 +name: neuroblast division in subpallium +namespace: biological_process +def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] +is_a: GO:0055057 ! neuroblast division +relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0021849 +name: neuroblast division in subventricular zone +namespace: biological_process +def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0055057 ! neuroblast division +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0021850 +name: subpallium glioblast cell division +namespace: biological_process +def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "glioblast cell division in subpallium" EXACT [] +synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447] +is_a: GO:0048860 ! glioblast division +relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0021851 +name: neuroblast division in dorsal lateral ganglionic eminence +namespace: biological_process +def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021848 ! neuroblast division in subpallium + +[Term] +id: GO:0021852 +name: pyramidal neuron migration to cerebral cortex +namespace: biological_process +def: "The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695, PMID:22192824] +synonym: "projection neuron migration" RELATED [PMID:12626695] +synonym: "pyramidal neuron migration" BROAD [] +is_a: GO:0021801 ! cerebral cortex radial glia-guided migration +is_a: GO:0140650 ! radial glia-guided pyramidal neuron migration +relationship: part_of GO:0021860 ! pyramidal neuron development + +[Term] +id: GO:0021853 +name: cerebral cortex GABAergic interneuron migration +namespace: biological_process +def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex +is_a: GO:1904936 ! interneuron migration +relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development + +[Term] +id: GO:0021854 +name: hypothalamus development +namespace: biological_process +def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0021761 ! limbic system development + +[Term] +id: GO:0021855 +name: hypothalamus cell migration +namespace: biological_process +def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0021854 ! hypothalamus development + +[Term] +id: GO:0021856 +name: hypothalamic tangential migration using cell-axon interactions +namespace: biological_process +def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021855 ! hypothalamus cell migration + +[Term] +id: GO:0021858 +name: GABAergic neuron differentiation in basal ganglia +namespace: biological_process +def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0097154 ! GABAergic neuron differentiation + +[Term] +id: GO:0021859 +name: pyramidal neuron differentiation +namespace: biological_process +def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "projection neuron differentiation" BROAD [PMID:16226447] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0021860 +name: pyramidal neuron development +namespace: biological_process +def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "projection neuron development" BROAD [PMID:16226447] +is_a: GO:0021884 ! forebrain neuron development +relationship: part_of GO:0021859 ! pyramidal neuron differentiation + +[Term] +id: GO:0021861 +name: forebrain radial glial cell differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "radial glial cell differentiation in forebrain" EXACT [] +is_a: GO:0060019 ! radial glial cell differentiation +relationship: part_of GO:0021872 ! forebrain generation of neurons + +[Term] +id: GO:0021862 +name: early neuron differentiation in forebrain +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021863 +name: forebrain neuroblast differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] +synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] +synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] +is_a: GO:0014016 ! neuroblast differentiation +relationship: part_of GO:0021872 ! forebrain generation of neurons + +[Term] +id: GO:0021864 +name: obsolete radial glial cell division in forebrain +namespace: biological_process +def: "OBSOLETE. The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021865 +name: obsolete symmetric radial glial cell division in forebrain +namespace: biological_process +def: "OBSOLETE. The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021866 +name: obsolete asymmetric radial glial cell division in forebrain +namespace: biological_process +def: "OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021867 +name: obsolete neuron-producing asymmetric radial glial cell division in forebrain +namespace: biological_process +def: "OBSOLETE. The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021868 +name: obsolete ventricular zone cell-producing asymmetric radial glial cell division in forebrain +namespace: biological_process +def: "OBSOLETE. The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021869 +name: forebrain ventricular zone progenitor cell division +namespace: biological_process +def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0021870 +name: Cajal-Retzius cell differentiation +namespace: biological_process +def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021895 ! cerebral cortex neuron differentiation + +[Term] +id: GO:0021871 +name: forebrain regionalization +namespace: biological_process +def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, PMID:16226447] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021872 +name: forebrain generation of neurons +namespace: biological_process +def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "generation of neurons in forebrain" EXACT [] +is_a: GO:0048699 ! generation of neurons +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021873 +name: forebrain neuroblast division +namespace: biological_process +def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0055057 ! neuroblast division +relationship: part_of GO:0021872 ! forebrain generation of neurons + +[Term] +id: GO:0021874 +name: Wnt signaling pathway involved in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "Wnt receptor signaling pathway involved in forebrain neuroblast division" EXACT [] +synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT [] +synonym: "Wnt-activated signaling pathway involved in forebrain neuroblast division" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021875 +name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021876 +name: Notch signaling pathway involved in forebrain neuroblast division +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT [] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0021873 ! forebrain neuroblast division + +[Term] +id: GO:0021877 +name: forebrain neuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021878 +name: forebrain astrocyte fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0060018 ! astrocyte fate commitment +relationship: part_of GO:0021896 ! forebrain astrocyte differentiation + +[Term] +id: GO:0021879 +name: forebrain neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0021872 ! forebrain generation of neurons + +[Term] +id: GO:0021880 +name: Notch signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0021881 +name: Wnt-activated signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "Wnt receptor signaling pathway involved in forebrain neuron fate commitment" EXACT [] +synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0021882 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021877 + +[Term] +id: GO:0021883 +name: obsolete cell cycle arrest of committed forebrain neuronal progenitor cell +namespace: biological_process +def: "OBSOLETE. The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:16226447] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0021884 +name: forebrain neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021954 ! central nervous system neuron development +relationship: part_of GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:0021885 +name: forebrain cell migration +namespace: biological_process +def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021886 +name: hypothalamus gonadotrophin-releasing hormone neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "hypothalamus gonadotropin-releasing hormone neuron differentiation" EXACT [GOC:dph] +is_a: GO:0021979 ! hypothalamus cell differentiation + +[Term] +id: GO:0021887 +name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "hypothalamus gonadotropin-releasing hormone neuron fate commitment" RELATED [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation + +[Term] +id: GO:0021888 +name: hypothalamus gonadotrophin-releasing hormone neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +synonym: "hypothalamus gonadotropin-releasing hormone neuron development" RELATED [GOC:dph] +is_a: GO:0021884 ! forebrain neuron development +relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation + +[Term] +id: GO:0021889 +name: olfactory bulb interneuron differentiation +namespace: biological_process +def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0021890 +name: olfactory bulb interneuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation + +[Term] +id: GO:0021891 +name: olfactory bulb interneuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation + +[Term] +id: GO:0021892 +name: cerebral cortex GABAergic interneuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021895 ! cerebral cortex neuron differentiation +is_a: GO:0097154 ! GABAergic neuron differentiation + +[Term] +id: GO:0021893 +name: cerebral cortex GABAergic interneuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation + +[Term] +id: GO:0021894 +name: cerebral cortex GABAergic interneuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021954 ! central nervous system neuron development +relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation + +[Term] +id: GO:0021895 +name: cerebral cortex neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021896 +name: forebrain astrocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0048708 ! astrocyte differentiation +relationship: part_of GO:0030900 ! forebrain development + +[Term] +id: GO:0021897 +name: forebrain astrocyte development +namespace: biological_process +def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0014002 ! astrocyte development +relationship: part_of GO:0021896 ! forebrain astrocyte differentiation + +[Term] +id: GO:0021898 +name: commitment of multipotent stem cells to neuronal lineage in forebrain +namespace: biological_process +def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695] +is_a: GO:0021877 ! forebrain neuron fate commitment + +[Term] +id: GO:0021899 +name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0021900 +name: ventricular zone cell fate commitment +namespace: biological_process +def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain +relationship: part_of GO:0021863 ! forebrain neuroblast differentiation + +[Term] +id: GO:0021901 +name: early neuron fate commitment in forebrain +namespace: biological_process +def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain +relationship: part_of GO:0021862 ! early neuron differentiation in forebrain + +[Term] +id: GO:0021902 +name: commitment of neuronal cell to specific neuron type in forebrain +namespace: biological_process +def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447] +is_a: GO:0021877 ! forebrain neuron fate commitment + +[Term] +id: GO:0021903 +name: rostrocaudal neural tube patterning +namespace: biological_process +def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0021532 ! neural tube patterning + +[Term] +id: GO:0021904 +name: dorsal/ventral neural tube patterning +namespace: biological_process +def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph] +synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0021532 ! neural tube patterning + +[Term] +id: GO:0021905 +name: forebrain-midbrain boundary formation +namespace: biological_process +def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0021906 +name: hindbrain-spinal cord boundary formation +namespace: biological_process +def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0021907 +name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021908 +name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021909 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021512 + +[Term] +id: GO:0021910 +name: smoothened signaling pathway involved in ventral spinal cord patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869] +synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT [] +is_a: GO:0007224 ! smoothened signaling pathway +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0021911 +name: retinoic acid metabolic process in spinal cord anterior-posterior patterning +namespace: biological_process +def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT [] +is_a: GO:0042573 ! retinoic acid metabolic process +relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning + +[Term] +id: GO:0021912 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021520 + +[Term] +id: GO:0021913 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021521 + +[Term] +id: GO:0021914 +name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:11262869] +synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] +synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW [] +synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT [] +is_a: GO:0045879 ! negative regulation of smoothened signaling pathway +relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0021915 +name: neural tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0035295 ! tube development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0007399 ! nervous system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0021916 +name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors +namespace: biological_process +def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT [] +is_a: GO:0031129 ! inductive cell-cell signaling +relationship: part_of GO:0021917 ! somatic motor neuron fate commitment + +[Term] +id: GO:0021917 +name: somatic motor neuron fate commitment +namespace: biological_process +def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021523 ! somatic motor neuron differentiation + +[Term] +id: GO:0021918 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021917 + +[Term] +id: GO:0021919 +name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981] +synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah] +synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah] +synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] +synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT [] +synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0021920 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0021519 + +[Term] +id: GO:0021921 +name: regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: part_of GO:0021516 ! dorsal spinal cord development +relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord + +[Term] +id: GO:0021922 +name: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981] +synonym: "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] +synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] +synonym: "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord + +[Term] +id: GO:0021923 +name: cell proliferation in hindbrain ventricular zone +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12593981, PMID:15157725] +is_a: GO:0021534 ! cell proliferation in hindbrain + +[Term] +id: GO:0021924 +name: cell proliferation in external granule layer +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021534 ! cell proliferation in hindbrain + +[Term] +id: GO:0021925 +name: cerebellar Purkinje cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone + +[Term] +id: GO:0021926 +name: Golgi cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone + +[Term] +id: GO:0021927 +name: deep nuclear neuron precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone + +[Term] +id: GO:0021928 +name: basket cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone + +[Term] +id: GO:0021929 +name: stellate cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone + +[Term] +id: GO:0021930 +name: cerebellar granule cell precursor proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021924 ! cell proliferation in external granule layer + +[Term] +id: GO:0021931 +name: rostral hindbrain neuronal precursor cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021924 ! cell proliferation in external granule layer + +[Term] +id: GO:0021932 +name: hindbrain radial glia guided cell migration +namespace: biological_process +def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021933 +name: radial glia guided migration of cerebellar granule cell +namespace: biological_process +def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021934 +name: hindbrain tangential cell migration +namespace: biological_process +def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725] +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021935 +name: cerebellar granule cell precursor tangential migration +namespace: biological_process +def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021934 ! hindbrain tangential cell migration + +[Term] +id: GO:0021936 +name: regulation of cerebellar granule cell precursor proliferation +namespace: biological_process +def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation + +[Term] +id: GO:0021937 +name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation +namespace: biological_process +def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0021940 ! positive regulation of cerebellar granule cell precursor proliferation + +[Term] +id: GO:0021938 +name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725] +synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT [] +is_a: GO:0007224 ! smoothened signaling pathway +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation + +[Term] +id: GO:0021939 +name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation +namespace: biological_process +def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT [] +is_a: GO:0035426 ! extracellular matrix-cell signaling +relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation + +[Term] +id: GO:0021940 +name: positive regulation of cerebellar granule cell precursor proliferation +namespace: biological_process +def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "activation of granule cell precursor proliferation" NARROW [] +synonym: "stimulation of granule cell precursor proliferation" NARROW [] +synonym: "up regulation of granule cell precursor proliferation" EXACT [] +synonym: "up-regulation of granule cell precursor proliferation" EXACT [] +synonym: "upregulation of granule cell precursor proliferation" EXACT [] +is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation +is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation + +[Term] +id: GO:0021941 +name: negative regulation of cerebellar granule cell precursor proliferation +namespace: biological_process +def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "down regulation of granule cell precursor proliferation" EXACT [] +synonym: "down-regulation of granule cell precursor proliferation" EXACT [] +synonym: "downregulation of granule cell precursor proliferation" EXACT [] +synonym: "inhibition of granule cell precursor proliferation" NARROW [] +is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation +is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation + +[Term] +id: GO:0021942 +name: radial glia guided migration of Purkinje cell +namespace: biological_process +def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021943 +name: formation of radial glial scaffolds +namespace: biological_process +def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725] +synonym: "Bergmann fiber formation" RELATED [PMID:15157725] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021944 +name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration +namespace: biological_process +def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration + +[Term] +id: GO:0021945 +name: positive regulation of cerebellar granule cell migration by calcium +namespace: biological_process +def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb, PMID:15157725] +synonym: "calcium-mediated activation of granule cell migration" NARROW [] +synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb] +synonym: "calcium-mediated stimulation of granule cell migration" NARROW [] +synonym: "calcium-mediated up regulation of granule cell migration" EXACT [] +synonym: "calcium-mediated up-regulation of granule cell migration" EXACT [] +synonym: "calcium-mediated upregulation of granule cell migration" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0030335 ! positive regulation of cell migration +relationship: part_of GO:0021933 ! radial glia guided migration of cerebellar granule cell + +[Term] +id: GO:0021946 +name: deep nuclear neuron cell migration +namespace: biological_process +def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021535 ! cell migration in hindbrain + +[Term] +id: GO:0021947 +name: outward migration of deep nuclear neurons +namespace: biological_process +def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0001764 ! neuron migration +is_a: GO:0021535 ! cell migration in hindbrain +relationship: part_of GO:0021946 ! deep nuclear neuron cell migration + +[Term] +id: GO:0021948 +name: inward migration of deep nuclear neurons +namespace: biological_process +def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0001764 ! neuron migration +is_a: GO:0021535 ! cell migration in hindbrain +relationship: part_of GO:0021946 ! deep nuclear neuron cell migration + +[Term] +id: GO:0021949 +name: brainstem precerebellar neuron precursor migration +namespace: biological_process +def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +is_a: GO:0021934 ! hindbrain tangential cell migration + +[Term] +id: GO:0021950 +name: chemorepulsion involved in precerebellar neuron migration +namespace: biological_process +def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration + +[Term] +id: GO:0021951 +name: chemoattraction involved in precerebellar neuron migration +namespace: biological_process +def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725] +synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration + +[Term] +id: GO:0021952 +name: central nervous system projection neuron axonogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "central nervous system axon tract development" NARROW [GOC:dph] +is_a: GO:0021955 ! central nervous system neuron axonogenesis + +[Term] +id: GO:0021953 +name: central nervous system neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0021954 +name: central nervous system neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021953 ! central nervous system neuron differentiation + +[Term] +id: GO:0021955 +name: central nervous system neuron axonogenesis +namespace: biological_process +def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0007409 ! axonogenesis +relationship: part_of GO:0021954 ! central nervous system neuron development + +[Term] +id: GO:0021956 +name: central nervous system interneuron axonogenesis +namespace: biological_process +def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021955 ! central nervous system neuron axonogenesis + +[Term] +id: GO:0021957 +name: corticospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] +synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021958 +name: gracilis tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698] +synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021959 +name: cuneatus tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12867698] +synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021960 +name: anterior commissure morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021961 +name: posterior commissure morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021962 +name: vestibulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021963 +name: spinothalamic tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT [] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021964 +name: rubrospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021965 +name: spinal cord ventral commissure morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0021966 +name: corticospinal neuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021957 ! corticospinal tract morphogenesis + +[Term] +id: GO:0021967 +name: corticospinal neuron axon guidance through the cerebral cortex +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021968 +name: corticospinal neuron axon guidance through the internal capsule +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021969 +name: corticospinal neuron axon guidance through the cerebral peduncle +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021970 +name: corticospinal neuron axon guidance through the basilar pons +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021971 +name: corticospinal neuron axon guidance through the medullary pyramid +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021972 +name: corticospinal neuron axon guidance through spinal cord +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021973 +name: corticospinal neuron axon decussation +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:9878731] +is_a: GO:0016199 ! axon midline choice point recognition +relationship: part_of GO:0021966 ! corticospinal neuron axon guidance + +[Term] +id: GO:0021974 +name: trigeminothalamic tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021975 +name: pons reticulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021976 +name: medulla reticulospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021977 +name: tectospinal tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0021978 +name: telencephalon regionalization +namespace: biological_process +def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0021537 ! telencephalon development +relationship: part_of GO:0021871 ! forebrain regionalization + +[Term] +id: GO:0021979 +name: hypothalamus cell differentiation +namespace: biological_process +def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021854 ! hypothalamus development + +[Term] +id: GO:0021980 +name: subpallium cell migration +namespace: biological_process +def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0021981 +name: subpallium radially oriented migration +namespace: biological_process +def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021980 ! subpallium cell migration + +[Term] +id: GO:0021982 +name: pineal gland development +namespace: biological_process +def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "epiphysis development" EXACT [GOC:dph] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0021983 +name: pituitary gland development +namespace: biological_process +def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "hypophysis development" RELATED [GOC:dph] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0021984 +name: adenohypophysis development +namespace: biological_process +def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "adenophysis development" EXACT [] +synonym: "anterior pituitary development" EXACT [] +synonym: "anterior pituitary gland development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021983 ! pituitary gland development + +[Term] +id: GO:0021985 +name: neurohypophysis development +namespace: biological_process +def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neurophysis development" EXACT [] +synonym: "posterior pituitary development" EXACT [] +synonym: "posterior pituitary gland development" EXACT [] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0021983 ! pituitary gland development + +[Term] +id: GO:0021986 +name: habenula development +namespace: biological_process +def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:9780721601465] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021538 ! epithalamus development + +[Term] +id: GO:0021987 +name: cerebral cortex development +namespace: biological_process +def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839] +synonym: "neocortex development" RELATED [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021543 ! pallium development + +[Term] +id: GO:0021988 +name: olfactory lobe development +namespace: biological_process +def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0021989 +name: olfactory cortex development +namespace: biological_process +def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021988 ! olfactory lobe development + +[Term] +id: GO:0021990 +name: neural plate formation +namespace: biological_process +def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878932437, ISBN:0878932585, PMID:15806586] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0021991 +name: neural plate thickening +namespace: biological_process +def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001839 ! neural plate morphogenesis + +[Term] +id: GO:0021992 +name: cell proliferation involved in neural plate elongation +namespace: biological_process +def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15806586] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0014022 ! neural plate elongation + +[Term] +id: GO:0021993 +name: initiation of neural tube closure +namespace: biological_process +def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021994 +name: progression of neural tube closure +namespace: biological_process +def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021995 +name: neuropore closure +namespace: biological_process +def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0021996 +name: lamina terminalis formation +namespace: biological_process +def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021506 ! anterior neuropore closure + +[Term] +id: GO:0021997 +name: neural plate axis specification +namespace: biological_process +def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neural plate axis determination" RELATED [GOC:dph] +is_a: GO:0000578 ! embryonic axis specification +relationship: part_of GO:0001840 ! neural plate development +relationship: part_of GO:0060896 ! neural plate pattern specification + +[Term] +id: GO:0021998 +name: neural plate mediolateral regionalization +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph] +is_a: GO:0060897 ! neural plate regionalization + +[Term] +id: GO:0021999 +name: neural plate anterior/posterior regionalization +namespace: biological_process +def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] +is_a: GO:0009952 ! anterior/posterior pattern specification +is_a: GO:0060897 ! neural plate regionalization + +[Term] +id: GO:0022000 +name: forebrain induction by the anterior neural ridge +namespace: biological_process +def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0031128 ! developmental induction +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0022001 +name: negative regulation of anterior neural cell fate commitment of the neural plate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb] +synonym: "caudalization of neural plate" EXACT [] +synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "posteriorization" BROAD [] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0051961 ! negative regulation of nervous system development +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0022002 +name: negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway +namespace: biological_process +def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb] +synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway" EXACT [] +synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] +is_a: GO:0016055 ! Wnt signaling pathway +is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate + +[Term] +id: GO:0022003 +name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:tb] +synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] +synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] +synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] +synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] +is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate +is_a: GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:0022004 +name: midbrain-hindbrain boundary maturation during brain development +namespace: biological_process +def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation + +[Term] +id: GO:0022005 +name: midbrain-hindbrain boundary maturation during neural plate development +namespace: biological_process +def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15541513] +synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation + +[Term] +id: GO:0022006 +name: zona limitans intrathalamica formation +namespace: biological_process +def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11425897, PMID:16452095] +synonym: "zli biosynthesis" EXACT [] +synonym: "zli formation" EXACT [] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0022007 +name: convergent extension involved in neural plate elongation +namespace: biological_process +def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:13679871, PMID:15806586] +is_a: GO:0060027 ! convergent extension involved in gastrulation +is_a: GO:0060029 ! convergent extension involved in organogenesis +relationship: part_of GO:0014022 ! neural plate elongation + +[Term] +id: GO:0022008 +name: neurogenesis +namespace: biological_process +def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +synonym: "nervous system cell generation" EXACT systematic_synonym [] +synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] +xref: Wikipedia:Neurogenesis +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0022009 +name: central nervous system vasculogenesis +namespace: biological_process +def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0001570 ! vasculogenesis + +[Term] +id: GO:0022010 +name: central nervous system myelination +namespace: biological_process +def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "myelination in central nervous system" EXACT [] +is_a: GO:0032291 ! axon ensheathment in central nervous system +is_a: GO:0042552 ! myelination +relationship: part_of GO:0014003 ! oligodendrocyte development + +[Term] +id: GO:0022011 +name: myelination in peripheral nervous system +namespace: biological_process +def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "peripheral nervous system myelination" EXACT [] +is_a: GO:0032292 ! peripheral nervous system axon ensheathment +is_a: GO:0042552 ! myelination +relationship: part_of GO:0014044 ! Schwann cell development + +[Term] +id: GO:0022012 +name: subpallium cell proliferation in forebrain +namespace: biological_process +def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021846 ! cell proliferation in forebrain +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0022013 +name: pallium cell proliferation in forebrain +namespace: biological_process +def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021846 ! cell proliferation in forebrain +relationship: part_of GO:0021543 ! pallium development + +[Term] +id: GO:0022014 +name: obsolete radial glial cell division in subpallium +namespace: biological_process +def: "OBSOLETE. The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0022015 +name: radial glial cell division in pallium +namespace: biological_process +def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain + +[Term] +id: GO:0022016 +name: pallium glioblast division +namespace: biological_process +def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "glioblast cell division in pallium" EXACT [] +is_a: GO:0048860 ! glioblast division +relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain + +[Term] +id: GO:0022017 +name: neuroblast division in pallium +namespace: biological_process +def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021873 ! forebrain neuroblast division +relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain + +[Term] +id: GO:0022018 +name: lateral ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0022019 +name: dorsal lateral ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022012 ! subpallium cell proliferation in forebrain +relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation + +[Term] +id: GO:0022020 +name: medial ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0022021 +name: caudal ganglionic eminence cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0022022 +name: septal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "septum cell proliferation" EXACT [] +is_a: GO:0022012 ! subpallium cell proliferation in forebrain + +[Term] +id: GO:0022023 +name: radial glial cell fate commitment in forebrain +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021781 ! glial cell fate commitment +is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain +relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation + +[Term] +id: GO:0022024 +name: BMP signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT [] +synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT [] +synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0022025 +name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:signaling] +synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0022026 +name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain + +[Term] +id: GO:0022027 +name: interkinetic nuclear migration +namespace: biological_process +def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0021846 ! cell proliferation in forebrain + +[Term] +id: GO:0022028 +name: tangential migration from the subventricular zone to the olfactory bulb +namespace: biological_process +def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "rostral migratory stream migration" EXACT [] +is_a: GO:0022029 ! telencephalon cell migration +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0022029 +name: telencephalon cell migration +namespace: biological_process +def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0021885 ! forebrain cell migration +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0022030 +name: telencephalon glial cell migration +namespace: biological_process +def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0008347 ! glial cell migration +is_a: GO:0022029 ! telencephalon cell migration + +[Term] +id: GO:0022031 +name: telencephalon astrocyte cell migration +namespace: biological_process +def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022030 ! telencephalon glial cell migration +is_a: GO:0043615 ! astrocyte cell migration + +[Term] +id: GO:0022032 +name: telencephalon oligodendrocyte cell migration +namespace: biological_process +def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0022033 +name: telencephalon microglial cell migration +namespace: biological_process +def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0022030 ! telencephalon glial cell migration + +[Term] +id: GO:0022034 +name: rhombomere cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022035 +name: rhombomere cell migration +namespace: biological_process +def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15629700] +is_a: GO:0021535 ! cell migration in hindbrain +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022036 +name: rhombomere cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021546 ! rhombomere development + +[Term] +id: GO:0022037 +name: metencephalon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030902 ! hindbrain development + +[Term] +id: GO:0022038 +name: corpus callosum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021537 ! telencephalon development + +[Term] +id: GO:0022400 +name: regulation of rhodopsin mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] +synonym: "regulation of rhodopsin mediated signalling" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0022401 +name: negative adaptation of signaling pathway +namespace: biological_process +def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete] +synonym: "negative adaptation of signal transduction pathway" EXACT [] +synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0023058 ! adaptation of signaling pathway + +[Term] +id: GO:0022402 +name: cell cycle process +namespace: biological_process +def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] +subset: gocheck_do_not_annotate +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0007049 ! cell cycle + +[Term] +id: GO:0022403 +name: cell cycle phase +namespace: biological_process +def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0044848 ! biological phase + +[Term] +id: GO:0022404 +name: molting cycle process +namespace: biological_process +def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0042303 ! molting cycle + +[Term] +id: GO:0022405 +name: hair cycle process +namespace: biological_process +def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0042633 ! hair cycle + +[Term] +id: GO:0022406 +name: membrane docking +namespace: biological_process +def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] +subset: goslim_pir +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0022407 +name: regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0022408 +name: negative regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] +synonym: "down regulation of cell-cell adhesion" EXACT [] +synonym: "down-regulation of cell-cell adhesion" EXACT [] +synonym: "downregulation of cell-cell adhesion" EXACT [] +synonym: "inhibition of cell-cell adhesion" NARROW [] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: negatively_regulates GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0022409 +name: positive regulation of cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] +synonym: "activation of cell-cell adhesion" NARROW [] +synonym: "stimulation of cell-cell adhesion" NARROW [] +synonym: "up regulation of cell-cell adhesion" EXACT [] +synonym: "up-regulation of cell-cell adhesion" EXACT [] +synonym: "upregulation of cell-cell adhesion" EXACT [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0022410 +name: circadian sleep/wake cycle process +namespace: biological_process +def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] +is_a: GO:0048512 ! circadian behavior +relationship: part_of GO:0042745 ! circadian sleep/wake cycle + +[Term] +id: GO:0022411 +name: cellular component disassembly +namespace: biological_process +alt_id: GO:0071845 +def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] +subset: goslim_pir +synonym: "cell structure disassembly" EXACT [] +synonym: "cellular component disassembly at cellular level" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0022412 +name: cellular process involved in reproduction in multicellular organism +namespace: biological_process +def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] +synonym: "reproductive cellular process in multicellular organism" EXACT [] +is_a: GO:0009987 ! cellular process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0032504 ! multicellular organism reproduction + +[Term] +id: GO:0022413 +name: reproductive process in single-celled organism +namespace: biological_process +def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0032505 ! reproduction of a single-celled organism + +[Term] +id: GO:0022414 +name: reproductive process +namespace: biological_process +alt_id: GO:0044702 +def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] +subset: goslim_generic +synonym: "single organism reproductive process" RELATED [] +is_a: GO:0008150 ! biological_process +relationship: part_of GO:0000003 ! reproduction + +[Term] +id: GO:0022416 +name: chaeta development +namespace: biological_process +def: "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] +synonym: "bristle development" NARROW [GOC:bf, GOC:dos] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0022417 +name: protein maturation by protein folding +namespace: biological_process +def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete] +is_a: GO:0006457 ! protein folding +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0022600 +name: digestive system process +namespace: biological_process +def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] +subset: goslim_generic +is_a: GO:0003008 ! system process +relationship: part_of GO:0007586 ! digestion + +[Term] +id: GO:0022601 +name: menstrual cycle phase +namespace: biological_process +def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0044848 ! biological phase + +[Term] +id: GO:0022602 +name: ovulation cycle process +namespace: biological_process +def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] +synonym: "estrous cycle process" RELATED [] +synonym: "menstrual cycle process" RELATED [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0048511 ! rhythmic process +relationship: part_of GO:0042698 ! ovulation cycle + +[Term] +id: GO:0022603 +name: regulation of anatomical structure morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] +synonym: "regulation of morphogenesis" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0022604 +name: regulation of cell morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] +synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0022605 +name: mammalian oogenesis stage +namespace: biological_process +def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] +synonym: "mammalian oogenesis process" EXACT [] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0022606 +name: establishment of proximal/distal cell polarity +namespace: biological_process +def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete] +is_a: GO:0061162 ! establishment of monopolar cell polarity + +[Term] +id: GO:0022607 +name: cellular component assembly +namespace: biological_process +alt_id: GO:0071844 +def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] +subset: goslim_chembl +subset: goslim_pir +synonym: "cell structure assembly" EXACT [] +synonym: "cellular component assembly at cellular level" EXACT [] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0022608 +name: multicellular organism adhesion +namespace: biological_process +def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete] +is_a: GO:0022610 ! biological adhesion +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0022609 +name: multicellular organism adhesion to substrate +namespace: biological_process +def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete] +is_a: GO:0022608 ! multicellular organism adhesion + +[Term] +id: GO:0022610 +name: biological adhesion +namespace: biological_process +def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] +subset: goslim_pir +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0022611 +name: dormancy process +namespace: biological_process +def: "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009] +comment: In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium. +synonym: "multicellular organism dormancy process" NARROW [] +synonym: "spore dormancy process" NARROW [GOC:PO_curators] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0022612 +name: gland morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048732 ! gland development + +[Term] +id: GO:0022613 +name: ribonucleoprotein complex biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] +synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] +synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] +is_a: GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0022614 +name: membrane to membrane docking +namespace: biological_process +def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete] +synonym: "membrane-membrane docking" EXACT [] +is_a: GO:0022406 ! membrane docking + +[Term] +id: GO:0022615 +name: protein to membrane docking +namespace: biological_process +def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] +synonym: "protein-membrane docking" EXACT [] +is_a: GO:0022406 ! membrane docking + +[Term] +id: GO:0022616 +name: DNA strand elongation +namespace: biological_process +def: "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0022617 +name: extracellular matrix disassembly +namespace: biological_process +def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0022618 +name: ribonucleoprotein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] +subset: goslim_chembl +synonym: "protein-RNA complex assembly" EXACT [] +synonym: "RNA-protein complex assembly" EXACT [] +synonym: "RNP complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0071826 ! ribonucleoprotein complex subunit organization +relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis + +[Term] +id: GO:0022619 +name: generative cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0055046 ! microgametogenesis + +[Term] +id: GO:0022620 +name: vegetative cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete] +synonym: "tube cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0055046 ! microgametogenesis + +[Term] +id: GO:0022622 +name: root system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0022623 +name: proteasome-activating nucleotidase complex +namespace: cellular_component +def: "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528] +synonym: "PAN" EXACT [PMID:19363223, PMID:19481528] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0022624 ! proteasome accessory complex + +[Term] +id: GO:0022624 +name: proteasome accessory complex +namespace: cellular_component +def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000502 ! proteasome complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0022625 +name: cytosolic large ribosomal subunit +namespace: cellular_component +alt_id: GO:0005842 +alt_id: GO:0009282 +alt_id: GO:0030498 +alt_id: GO:0030872 +def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] +synonym: "50S ribosomal subunit" NARROW [] +synonym: "60S ribosomal subunit" NARROW [] +synonym: "eukaryotic ribosomal LSU" NARROW [] +synonym: "prokaryotic large ribosomal subunit" NARROW [] +is_a: GO:0015934 ! large ribosomal subunit +relationship: part_of GO:0022626 ! cytosolic ribosome + +[Term] +id: GO:0022626 +name: cytosolic ribosome +namespace: cellular_component +alt_id: GO:0005830 +alt_id: GO:0009281 +alt_id: GO:0030871 +def: "A ribosome located in the cytosol." [GOC:mtg_sensu] +synonym: "70S ribosome" NARROW [] +synonym: "80S ribosome" NARROW [] +is_a: GO:0005840 ! ribosome +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0022627 +name: cytosolic small ribosomal subunit +namespace: cellular_component +alt_id: GO:0005843 +alt_id: GO:0009283 +alt_id: GO:0030499 +alt_id: GO:0030873 +def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] +synonym: "30S ribosomal subunit" NARROW [] +synonym: "40S ribosomal subunit" NARROW [] +synonym: "eukaryotic ribosomal SSU" NARROW [] +synonym: "prokaryotic small ribosomal subunit" NARROW [] +is_a: GO:0015935 ! small ribosomal subunit +relationship: part_of GO:0022626 ! cytosolic ribosome + +[Term] +id: GO:0022628 +name: chloroplast large ribosomal subunit +namespace: cellular_component +def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] +synonym: "chloroplast ribosomal large subunit complex" EXACT [] +synonym: "chloroplast ribosomal LSU complex" EXACT [] +is_a: GO:0000311 ! plastid large ribosomal subunit +relationship: part_of GO:0043253 ! chloroplast ribosome + +[Term] +id: GO:0022629 +name: chloroplast small ribosomal subunit +namespace: cellular_component +def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] +synonym: "chloroplast ribosomal small subunit complex" EXACT [] +synonym: "chloroplast ribosomal SSU complex" EXACT [] +is_a: GO:0000312 ! plastid small ribosomal subunit +relationship: part_of GO:0043253 ! chloroplast ribosome + +[Term] +id: GO:0022803 +name: passive transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0022814 +def: "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +synonym: "facilitated diffusion" RELATED [] +synonym: "porters" BROAD [] +synonym: "uniporter activity z" NARROW [] +xref: Reactome:R-HSA-429767 "Passive I- efflux mediated by SMCT1" +xref: Wikipedia:Facilitated_diffusion +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022804 +name: active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +synonym: "active carrier activity" EXACT [] +synonym: "carrier activity" EXACT [] +synonym: "permease activity" EXACT [] +synonym: "pump activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022809 +name: mobile ion carrier activity +namespace: molecular_function +def: "Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] +synonym: "ionophore" BROAD [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022810 +name: membrane potential driven uniporter activity +namespace: molecular_function +def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +synonym: "porter" BROAD [] +is_a: GO:0015292 ! uniporter activity + +[Term] +id: GO:0022815 +name: obsolete large uncharged polar molecule transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. +synonym: "large uncharged polar molecule transmembrane transporter activity" EXACT [] +is_obsolete: true +replaced_by: GO:0022857 + +[Term] +id: GO:0022818 +name: sodium ion uniporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0022810 ! membrane potential driven uniporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0022819 +name: potassium ion uniporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0022810 ! membrane potential driven uniporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0022821 +name: potassium ion antiporter activity +namespace: molecular_function +def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015079 ! potassium ion transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity + +[Term] +id: GO:0022824 +name: transmitter-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart] +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity +is_a: GO:0022835 ! transmitter-gated channel activity + +[Term] +id: GO:0022825 +name: obsolete copper-exporting ATPase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined. +synonym: "copper-exporting ATPase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0043682 + +[Term] +id: GO:0022828 +name: phosphorylation-gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022829 +name: wide pore channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "gap junction activity" NARROW [] +synonym: "non-gated, wide pore channel activity" EXACT [] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022831 +name: narrow pore, gated channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ion channels" RELATED [] +xref: Wikipedia:Ion_channels +is_a: GO:0022842 ! narrow pore channel activity + +[Term] +id: GO:0022832 +name: voltage-gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022834 +name: ligand-gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022835 +name: transmitter-gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "extracellular substance gated channel activity" EXACT [] +synonym: "neurotransmitter-gated channel activity" EXACT [] +is_a: GO:0022834 ! ligand-gated channel activity +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0022836 +name: gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022839 +name: ion gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022840 +name: leak channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022842 ! narrow pore channel activity + +[Term] +id: GO:0022841 +name: potassium ion leak channel activity +namespace: molecular_function +def: "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022840 ! leak channel activity + +[Term] +id: GO:0022842 +name: narrow pore channel activity +namespace: molecular_function +def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022843 +name: voltage-gated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] +xref: Reactome:R-HSA-2534378 "Hv1 Mediated H+ Permeability" +xref: Reactome:R-HSA-6788999 "HV1-mediated H+ transfer" +is_a: GO:0005244 ! voltage-gated ion channel activity +is_a: GO:0005261 ! cation channel activity + +[Term] +id: GO:0022848 +name: acetylcholine-gated cation-selective channel activity +namespace: molecular_function +alt_id: GO:0004889 +alt_id: GO:0016904 +def: "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] +synonym: "acetylcholine-activated cation-selective channel activity" EXACT [] +synonym: "acetylcholine-gated cation channel activity" EXACT [] +synonym: "ionotropic acetylcholine receptor activity" EXACT [] +synonym: "nAChR" EXACT [] +synonym: "nicotinergic acetylcholine receptor activity" EXACT [] +synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf] +is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity +is_a: GO:1904315 ! transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential + +[Term] +id: GO:0022849 +name: glutamate-gated calcium ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0004970 ! ionotropic glutamate receptor activity +is_a: GO:0099604 ! ligand-gated calcium channel activity + +[Term] +id: GO:0022850 +name: serotonin-gated cation-selective channel activity +namespace: molecular_function +alt_id: GO:0005232 +def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'. +synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW [] +synonym: "serotonin-activated cation-selective channel activity" EXACT [] +synonym: "serotonin-gated cation channel activity" NARROW [] +xref: Reactome:R-HSA-9648983 "HTR3A pentamer:5HT transports Na+,K+,Ca2+" +xref: Reactome:R-HSA-975311 "HTR3 pentamers:5HT transport Na+,K+,Ca2+" +is_a: GO:0022824 ! transmitter-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0022851 +name: GABA-gated chloride ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0016917 ! GABA receptor activity +is_a: GO:0022824 ! transmitter-gated ion channel activity +is_a: GO:0099095 ! ligand-gated anion channel activity + +[Term] +id: GO:0022852 +name: glycine-gated chloride ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0022824 ! transmitter-gated ion channel activity +is_a: GO:0099095 ! ligand-gated anion channel activity + +[Term] +id: GO:0022853 +name: active ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0022854 +name: obsolete active large uncharged polar molecule transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. +synonym: "active large uncharged polar molecule transmembrane transporter activity" EXACT [] +is_obsolete: true +replaced_by: GO:0022804 + +[Term] +id: GO:0022855 +name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "glucose PTS transporter activity" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022856 +name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "sorbitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015576 ! sorbitol transmembrane transporter activity + +[Term] +id: GO:0022857 +name: transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005386 +alt_id: GO:0015563 +alt_id: GO:0015646 +alt_id: GO:0022891 +alt_id: GO:0022892 +def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "substrate-specific transmembrane transporter activity" RELATED [] +synonym: "substrate-specific transporter activity" RELATED [] +synonym: "uptake permease activity" RELATED [] +synonym: "uptake transmembrane transporter activity" RELATED [] +xref: Reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" +xref: Reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" +xref: Reactome:R-HSA-5638209 "Defective SLC2A9 does not transport Fru, Glc, urate" +xref: Reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" +xref: Reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" +xref: Reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0022858 +name: alanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0022859 +name: dephosphorylation-gated channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0022865 +name: obsolete transmembrane electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] +comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. +xref: TC:5 +is_obsolete: true + +[Term] +id: GO:0022866 +name: obsolete transmembrane 1-electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] +comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. +synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0022867 +name: obsolete transmembrane 2-electron transfer carrier +namespace: molecular_function +def: "OBSOLETE. Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] +comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. +synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0022869 +name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "lactose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015155 ! lactose transmembrane transporter activity + +[Term] +id: GO:0022870 +name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "mannose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015578 ! mannose transmembrane transporter activity + +[Term] +id: GO:0022871 +name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, PMID:10613875, RHEA:49296] +synonym: "sorbose PTS transporter activity" EXACT [] +xref: EC:2.7.1.206 +xref: RHEA:49296 +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019194 ! sorbose transmembrane transporter activity + +[Term] +id: GO:0022872 +name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "mannitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015575 ! mannitol transmembrane transporter activity + +[Term] +id: GO:0022873 +name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "maltose PTS transporter activity" EXACT [] +is_a: GO:0005363 ! maltose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022874 +name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "cellobiose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019191 ! cellobiose transmembrane transporter activity + +[Term] +id: GO:0022875 +name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "galactitol PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015577 ! galactitol transmembrane transporter activity + +[Term] +id: GO:0022876 +name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "galactosamine PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0019196 ! galactosamine transmembrane transporter activity + +[Term] +id: GO:0022877 +name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "fructose PTS transporter activity" EXACT [] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022878 +name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "sucrose PTS transporter activity" EXACT [] +xref: MetaCyc:SUCROSEPHOSPHO-RXN +xref: RHEA:49236 +is_a: GO:0008515 ! sucrose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0022879 +name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "trehalose PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015574 ! trehalose transmembrane transporter activity + +[Term] +id: GO:0022880 +name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity +is_a: GO:0015574 ! trehalose transmembrane transporter activity + +[Term] +id: GO:0022881 +name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] +is_a: GO:0005355 ! glucose transmembrane transporter activity +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity + +[Term] +id: GO:0022882 +name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] +synonym: "beta-glucoside PTS transporter activity" EXACT [] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity + +[Term] +id: GO:0022883 +name: zinc efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] +synonym: "zinc efflux permease activity" EXACT [] +is_a: GO:0005385 ! zinc ion transmembrane transporter activity +is_a: GO:0046583 ! cation efflux transmembrane transporter activity + +[Term] +id: GO:0022884 +name: macromolecule transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0022885 +name: bacteriocin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a bacteriocin from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0022886 +name: channel-forming ionophore activity +namespace: molecular_function +def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ionophore activity" BROAD [] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0022889 +name: serine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0022890 +name: inorganic cation transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015077 +alt_id: GO:0015082 +alt_id: GO:0072509 +alt_id: GO:0072510 +def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] +synonym: "divalent inorganic cation transmembrane transporter activity" NARROW [] +synonym: "monovalent inorganic cation transmembrane transporter activity" NARROW [] +synonym: "trivalent inorganic cation transmembrane transporter activity" NARROW [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0022893 +name: low-affinity tryptophan transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015510 +def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] +synonym: "low-affinity tryptophan permease activity" RELATED [] +is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity + +[Term] +id: GO:0022894 +name: Intermediate conductance calcium-activated potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] +synonym: "IK calcium-activated potassium channel activity" EXACT [] +synonym: "IK KCa channels" EXACT [] +synonym: "intermdiate conductance KCa channels" EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0022897 +name: proton-dependent peptide secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] +synonym: "hydrogen/oligopeptide symporter" RELATED [] +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:0022898 +name: regulation of transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0034762 ! regulation of transmembrane transport + +[Term] +id: GO:0022900 +name: electron transport chain +namespace: biological_process +def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors." [GOC:mtg_electron_transport] +subset: goslim_pir +xref: Wikipedia:Electron_transport_chain +is_a: GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0022904 +name: respiratory electron transport chain +namespace: biological_process +def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] +synonym: "6-phosphofructokinase reduction" RELATED [] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "dihydrolipoamide reduction" RELATED [] +synonym: "dihydrolipoylprotein reduction" RELATED [] +synonym: "dihydropteridine reduction" RELATED [] +synonym: "electron transfer" EXACT [] +synonym: "other pathways of electron transport" RELATED [] +synonym: "oxidized glutathione reduction" RELATED [] +synonym: "protein-disulfide reduction" RELATED [] +xref: Wikipedia:Electron_transfer +is_a: GO:0022900 ! electron transport chain +relationship: part_of GO:0045333 ! cellular respiration + +[Term] +id: GO:0023002 +name: nuclear migration to embryo sac poles +namespace: biological_process +def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] +synonym: "nuclear migration to female gametophyte poles" EXACT [] +synonym: "nuclear migration to megagametophyte poles" EXACT [] +synonym: "nucleus migration to embryo sac poles" EXACT [] +synonym: "nucleus migration to female gametophyte poles" EXACT [] +synonym: "nucleus migration to megagametophyte poles" EXACT [] +is_a: GO:0009562 ! embryo sac nuclear migration + +[Term] +id: GO:0023003 +name: nuclear migration to the embryo sac center +namespace: biological_process +def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] +synonym: "nuclear migration to the embryo sac centre" EXACT [] +synonym: "nuclear migration to the female gametophyte center" EXACT [] +synonym: "nuclear migration to the female gametophyte centre" EXACT [] +synonym: "nuclear migration to the megagametophyte center" EXACT [] +synonym: "nuclear migration to the megagametophyte centre" EXACT [] +synonym: "nucleus migration to the female gametophyte center" EXACT [] +synonym: "nucleus migration to the female gametophyte centre" EXACT [] +is_a: GO:0009562 ! embryo sac nuclear migration + +[Term] +id: GO:0023004 +name: obsolete activation of dopamine receptor signaling pathway +namespace: biological_process +def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "activation of dopamine receptor signaling pathway" EXACT [] +synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah] +synonym: "initiation of dopamine receptor signaling pathway" RELATED [] +synonym: "stimulation of dopamine receptor signaling pathway" EXACT [] +is_obsolete: true +consider: GO:0060161 + +[Term] +id: GO:0023005 +name: obsolete signal initiation by neurotransmitter +namespace: biological_process +def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by neurotransmitter" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0030594 + +[Term] +id: GO:0023006 +name: obsolete signal initiation by amino acid +namespace: biological_process +def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by amino acid" EXACT [] +is_obsolete: true +consider: GO:0007215 +consider: GO:0008066 +consider: GO:0071230 + +[Term] +id: GO:0023007 +name: obsolete ligand binding to T cell receptor +namespace: biological_process +def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal] +comment: This term was made obsolete because it is describing a binding molecular function. +synonym: "ligand binding to T cell receptor" EXACT [] +is_obsolete: true +consider: GO:0042101 +consider: GO:0042608 +consider: GO:0050852 + +[Term] +id: GO:0023009 +name: obsolete initiation of T cell receptor signaling +namespace: biological_process +def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "initiation of T cell receptor signaling" EXACT [] +synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0038023 +consider: GO:0042101 +consider: GO:0048018 +consider: GO:0050852 + +[Term] +id: GO:0023010 +name: obsolete regulation of initiation of T cell receptor signaling +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "regulation of initiation of T cell receptor signaling" EXACT [] +synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0050856 + +[Term] +id: GO:0023011 +name: obsolete positive regulation of initiation of T cell receptor signaling +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "positive regulation of initiation of T cell receptor signaling" EXACT [] +synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0050862 + +[Term] +id: GO:0023012 +name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor +namespace: biological_process +def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal] +comment: This term was made obsolete because it is describing a binding molecular function. +synonym: "initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor" EXACT [] +synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0042101 +consider: GO:0050852 + +[Term] +id: GO:0023017 +name: obsolete signal transmission via diffusible molecule +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via diffusible molecule" EXACT [] +synonym: "signaling via diffusible mediator" EXACT [] +is_obsolete: true +consider: GO:0007267 + +[Term] +id: GO:0023018 +name: obsolete T cell activation of signal transmission via diffusible molecule +namespace: biological_process +def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "T cell activation of signal transmission via diffusible molecule" EXACT [] +is_obsolete: true + +[Term] +id: GO:0023019 +name: signal transduction involved in regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] +synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0010468 ! regulation of gene expression + +[Term] +id: GO:0023020 +name: obsolete regulation of gene expression as a consequence of T cell signal transmission +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "regulation of gene expression as a consequence of T cell signal transmission" EXACT [] +is_obsolete: true +consider: GO:0023019 + +[Term] +id: GO:0023021 +name: termination of signal transduction +namespace: biological_process +def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] +comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. +is_a: GO:0009968 ! negative regulation of signal transduction + +[Term] +id: GO:0023022 +name: termination of T cell signal transduction +namespace: biological_process +def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] +is_a: GO:0023021 ! termination of signal transduction +is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway +relationship: part_of GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0023023 +name: MHC protein complex binding +namespace: molecular_function +def: "Binding to a major histocompatibility complex." [GOC:mtg_signal, GOC:vw] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0023024 +name: MHC class I protein complex binding +namespace: molecular_function +def: "Binding to a class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw] +is_a: GO:0023023 ! MHC protein complex binding + +[Term] +id: GO:0023025 +name: MHC class Ib protein complex binding +namespace: molecular_function +def: "Binding to a class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw] +is_a: GO:0023023 ! MHC protein complex binding + +[Term] +id: GO:0023026 +name: MHC class II protein complex binding +namespace: molecular_function +def: "Binding to a class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] +is_a: GO:0023023 ! MHC protein complex binding + +[Term] +id: GO:0023027 +name: MHC class I protein binding, via antigen binding groove +namespace: molecular_function +def: "Binding to a major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] +is_a: GO:0042288 ! MHC class I protein binding +relationship: part_of GO:0023024 ! MHC class I protein complex binding + +[Term] +id: GO:0023028 +name: MHC class I protein binding, via lateral surface +namespace: molecular_function +def: "Binding to a major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] +is_a: GO:0042288 ! MHC class I protein binding + +[Term] +id: GO:0023029 +name: MHC class Ib protein binding +namespace: molecular_function +def: "Binding to a major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw] +is_a: GO:0042287 ! MHC protein binding + +[Term] +id: GO:0023030 +name: MHC class Ib protein binding, via antigen binding groove +namespace: molecular_function +def: "Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] +is_a: GO:0023029 ! MHC class Ib protein binding +relationship: part_of GO:0023025 ! MHC class Ib protein complex binding + +[Term] +id: GO:0023031 +name: MHC class Ib protein binding, via lateral surface +namespace: molecular_function +def: "Binding to a major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] +is_a: GO:0023029 ! MHC class Ib protein binding + +[Term] +id: GO:0023035 +name: CD40 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017] +synonym: "CD40 signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0023036 +name: obsolete initiation of signal transduction +namespace: biological_process +def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors. +synonym: "initiation of signal transduction" EXACT [] +synonym: "signal reception" RELATED [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038023 +consider: GO:0048018 + +[Term] +id: GO:0023037 +name: obsolete signal initiation by light +namespace: biological_process +def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by light" EXACT [] +is_obsolete: true +consider: GO:0009785 +consider: GO:0009881 +consider: GO:0010017 +consider: GO:0010018 +consider: GO:0010161 + +[Term] +id: GO:0023038 +name: obsolete signal initiation by diffusible mediator +namespace: biological_process +def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by diffusible mediator" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038001 +consider: GO:0038023 +consider: GO:0048018 + +[Term] +id: GO:0023039 +name: obsolete signal initiation by physical damage +namespace: biological_process +def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by physical damage" EXACT [] +is_obsolete: true +consider: GO:0033554 +consider: GO:0038023 + +[Term] +id: GO:0023040 +name: obsolete signaling via ionic flux +namespace: biological_process +def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signaling via ionic flux" EXACT [] +synonym: "signalling via ionic flux" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0023052 + +[Term] +id: GO:0023041 +name: neuronal signal transduction +namespace: biological_process +def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0023042 +name: obsolete signaling via protein/peptide mediator +namespace: biological_process +def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signaling via protein/peptide mediator" EXACT [] +synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0023052 + +[Term] +id: GO:0023043 +name: obsolete signaling via lipid mediator +namespace: biological_process +def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signaling via lipid mediator" EXACT [] +synonym: "signalling via lipid mediator" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0014065 +consider: GO:0023052 + +[Term] +id: GO:0023044 +name: obsolete signaling via chemical mediator +namespace: biological_process +def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signaling via chemical mediator" EXACT [] +synonym: "signalling via chemical mediator" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0023052 + +[Term] +id: GO:0023047 +name: obsolete signal initiation by chemical mediator +namespace: biological_process +def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by chemical mediator" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038023 +consider: GO:0070887 + +[Term] +id: GO:0023048 +name: obsolete signal initiation by lipid mediator +namespace: biological_process +def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by lipid mediator" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0045125 + +[Term] +id: GO:0023049 +name: obsolete signal initiation by protein/peptide mediator +namespace: biological_process +def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by protein/peptide mediator" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038023 +consider: GO:0048018 + +[Term] +id: GO:0023050 +name: obsolete consequence of signal transmission +namespace: biological_process +def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal] +comment: This term was made obsolete because the term is no longer needed. +synonym: "consequence of signal transmission" EXACT [] +synonym: "signal termination" EXACT [] +is_obsolete: true + +[Term] +id: GO:0023051 +name: regulation of signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] +synonym: "regulation of signaling process" RELATED [GOC:bf] +synonym: "regulation of signalling process" RELATED [GOC:mah] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0023052 ! signaling + +[Term] +id: GO:0023052 +name: signaling +namespace: biological_process +alt_id: GO:0023046 +alt_id: GO:0044700 +def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] +comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. +subset: goslim_agr +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_pombe +subset: goslim_yeast +synonym: "biological signaling" EXACT [] +synonym: "signaling process" EXACT [] +synonym: "signalling" EXACT [] +synonym: "signalling process" RELATED [GOC:mah] +synonym: "single organism signaling" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0023053 +name: obsolete signal initiation by mechanical effect +namespace: biological_process +def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by mechanical effect" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038023 +consider: GO:0071260 + +[Term] +id: GO:0023054 +name: obsolete signal initiation by stretch effect +namespace: biological_process +def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by stretch effect" EXACT [] +is_obsolete: true +consider: GO:0007165 +consider: GO:0038023 + +[Term] +id: GO:0023055 +name: obsolete signal initiation by peptide hormone +namespace: biological_process +def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal initiation by peptide hormone" EXACT [] +is_obsolete: true +consider: GO:0004879 +consider: GO:0005179 +consider: GO:0009755 + +[Term] +id: GO:0023056 +name: positive regulation of signaling +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] +synonym: "positive regulation of signaling process" RELATED [GOC:bf] +synonym: "positive regulation of signalling process" EXACT [GOC:mah] +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0023052 ! signaling + +[Term] +id: GO:0023057 +name: negative regulation of signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] +synonym: "negative regulation of signaling process" RELATED [GOC:bf] +synonym: "negative regulation of signalling process" RELATED [GOC:mah] +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0023052 ! signaling + +[Term] +id: GO:0023058 +name: adaptation of signaling pathway +namespace: biological_process +def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] +synonym: "adaptation of signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction + +[Term] +id: GO:0023059 +name: positive adaptation of signaling pathway +namespace: biological_process +def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] +synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0023058 ! adaptation of signaling pathway + +[Term] +id: GO:0023060 +name: obsolete signal transmission +namespace: biological_process +def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "signal transmission" EXACT [] +is_obsolete: true +consider: GO:0023052 + +[Term] +id: GO:0023061 +name: signal release +namespace: biological_process +def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] +synonym: "signal secretion" EXACT [GOC:bf] +is_a: GO:0032940 ! secretion by cell +relationship: part_of GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0023062 +name: obsolete signal transmission via transcytosis +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via transcytosis" EXACT [] +is_obsolete: true +consider: GO:0023052 +consider: GO:0045056 + +[Term] +id: GO:0023065 +name: obsolete signal transmission via blood +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via blood" EXACT [] +is_obsolete: true +consider: GO:0010232 +consider: GO:0023052 + +[Term] +id: GO:0023066 +name: obsolete signal transmission via vascular system +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via vascular system" EXACT [] +is_obsolete: true +consider: GO:0010232 +consider: GO:0023052 + +[Term] +id: GO:0023067 +name: obsolete signal transmission via lymphatic system +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via lymphatic system" EXACT [] +is_obsolete: true +consider: GO:0023052 + +[Term] +id: GO:0023068 +name: obsolete signal transmission via phloem +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via phloem" EXACT [] +is_obsolete: true +consider: GO:0010233 +consider: GO:0023052 + +[Term] +id: GO:0023069 +name: obsolete signal transmission via xylem +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via xylem" EXACT [] +is_obsolete: true +consider: GO:0010232 +consider: GO:0023052 + +[Term] +id: GO:0023070 +name: obsolete signal transmission via air +namespace: biological_process +def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "signal transmission via air" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030001 +name: metal ion transport +namespace: biological_process +alt_id: GO:0070838 +def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "divalent metal ion transport" NARROW [] +synonym: "heavy metal ion transport" NARROW [] +is_a: GO:0006812 ! cation transport + +[Term] +id: GO:0030002 +name: cellular anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah] +is_a: GO:0006873 ! cellular ion homeostasis +is_a: GO:0055081 ! anion homeostasis + +[Term] +id: GO:0030003 +name: cellular cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah] +is_a: GO:0006873 ! cellular ion homeostasis +is_a: GO:0055080 ! cation homeostasis + +[Term] +id: GO:0030004 +name: cellular monovalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah] +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0030005 +name: obsolete cellular di-, tri-valent inorganic cation homeostasis +namespace: biological_process +def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah] +synonym: "cellular di-, tri-valent inorganic cation homeostasis" EXACT [] +is_obsolete: true +consider: GO:0072503 +consider: GO:0072504 + +[Term] +id: GO:0030006 +name: obsolete heavy cellular metal ion homeostasis +namespace: biological_process +def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] +comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). +synonym: "heavy cellular metal ion homeostasis" EXACT [] +is_obsolete: true +consider: GO:0006875 + +[Term] +id: GO:0030007 +name: cellular potassium ion homeostasis +namespace: biological_process +alt_id: GO:0017079 +def: "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0055075 ! potassium ion homeostasis + +[Term] +id: GO:0030008 +name: TRAPP complex +namespace: cellular_component +def: "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257] +synonym: "transport protein particle" EXACT [] +synonym: "transport protein particle complex" EXACT [GOC:bhm] +synonym: "TRAPP1" NARROW [GOC:vw] +synonym: "TRAPP2" NARROW [GOC:vw] +xref: Wikipedia:TRAPP_complex +is_a: GO:0099023 ! vesicle tethering complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0030009 +name: obsolete complement factor H activity +namespace: molecular_function +def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684] +comment: This term was made obsolete because it represents a gene product. +synonym: "complement factor H activity" EXACT [] +is_obsolete: true +consider: GO:0006956 + +[Term] +id: GO:0030010 +name: establishment of cell polarity +namespace: biological_process +alt_id: GO:0000283 +alt_id: GO:0030468 +def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +synonym: "bud site selection/establishment of cell polarity" NARROW [] +synonym: "cell polarization" EXACT [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0030011 +name: maintenance of cell polarity +namespace: biological_process +alt_id: GO:0030013 +alt_id: GO:0030469 +def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0030014 +name: CCR4-NOT complex +namespace: cellular_component +def: "The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." [GOC:sart, PMID:11113136, PMID:11239395, PMID:22785621, PMID:30601114] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0030015 +name: CCR4-NOT core complex +namespace: cellular_component +def: "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030014 ! CCR4-NOT complex + +[Term] +id: GO:0030016 +name: myofibril +namespace: cellular_component +def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] +xref: Wikipedia:Myofibril +is_a: GO:0043292 ! contractile fiber + +[Term] +id: GO:0030017 +name: sarcomere +namespace: cellular_component +def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] +xref: Wikipedia:Sarcomere +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030016 ! myofibril + +[Term] +id: GO:0030018 +name: Z disc +namespace: cellular_component +def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] +synonym: "Z band" EXACT [] +synonym: "Z disk" EXACT [] +synonym: "Z line" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031674 ! I band + +[Term] +id: GO:0030019 +name: obsolete tryptase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "lung tryptase activity" NARROW [] +synonym: "mast cell neutral proteinase activity" RELATED [] +synonym: "mast cell protease II activity" NARROW [] +synonym: "mast cell proteinase II" RELATED [] +synonym: "mast cell serine proteinase II" RELATED [] +synonym: "mast cell serine proteinase tryptase activity" RELATED [] +synonym: "mast cell tryptase activity" NARROW [] +synonym: "pituitary tryptase activity" NARROW [] +synonym: "rat mast cell protease II" RELATED [] +synonym: "skin tryptase activity" NARROW [] +synonym: "tryptase activity" EXACT [] +synonym: "tryptase M" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030020 +name: extracellular matrix structural constituent conferring tensile strength +namespace: molecular_function +def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] +comment: Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019 +synonym: "core extracellular matrix" BROAD [] +synonym: "core matrisome" BROAD [] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030021 +name: extracellular matrix structural constituent conferring compression resistance +namespace: molecular_function +def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] +comment: Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704 +synonym: "core extracellular matrix" BROAD [] +synonym: "core matrisome" BROAD [] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030022 +name: obsolete adhesive extracellular matrix constituent +namespace: molecular_function +def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "adhesive extracellular matrix constituent" EXACT [] +is_obsolete: true +consider: GO:0030674 +consider: GO:0031012 +consider: GO:0050839 +consider: GO:0050840 + +[Term] +id: GO:0030023 +name: extracellular matrix constituent conferring elasticity +namespace: molecular_function +def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] +comment: Extracellular matrix elastin proteins may be annotated to this term. PMID:27009176, PMID:24443019 +synonym: "core extracellular matrix" BROAD [] +synonym: "core matrisome" BROAD [] +synonym: "elastin" RELATED [] +is_a: GO:0005201 ! extracellular matrix structural constituent +is_a: GO:0097493 ! structural molecule activity conferring elasticity + +[Term] +id: GO:0030026 +name: cellular manganese ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah] +synonym: "manganese homeostasis" BROAD [] +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0055071 ! manganese ion homeostasis + +[Term] +id: GO:0030027 +name: lamellipodium +namespace: cellular_component +def: "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] +xref: Wikipedia:Lamellipodia +is_a: GO:0120025 ! plasma membrane bounded cell projection +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0030029 +name: actin filament-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] +synonym: "microfilament-based process" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0030030 +name: cell projection organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] +synonym: "cell projection organisation" EXACT [] +synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] +synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0030031 +name: cell projection assembly +namespace: biological_process +def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] +synonym: "cell projection biogenesis" RELATED [GOC:mah] +synonym: "formation of a cell surface projection" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0030032 +name: lamellipodium assembly +namespace: biological_process +def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] +synonym: "lamellipodium biogenesis" RELATED [GOC:mah] +synonym: "lamellipodium biosynthesis" EXACT [] +synonym: "lamellipodium formation" EXACT [] +is_a: GO:0097581 ! lamellipodium organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0030033 +name: microvillus assembly +namespace: biological_process +def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] +synonym: "microvillus biogenesis" RELATED [GOC:mah] +is_a: GO:0032528 ! microvillus organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0030034 +name: microvillar actin bundle assembly +namespace: biological_process +def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah] +is_a: GO:0030046 ! parallel actin filament bundle assembly +relationship: part_of GO:0030033 ! microvillus assembly + +[Term] +id: GO:0030035 +name: microspike assembly +namespace: biological_process +def: "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735] +comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. For the assembly of filopodia, use 'filopodium assembly ; GO:0046847'. +synonym: "microspike biogenesis" RELATED [GOC:mah] +synonym: "microspike biosynthesis" EXACT [] +synonym: "microspike formation" EXACT [] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0030036 +name: actin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pombe +synonym: "actin cytoskeleton organisation" EXACT [] +synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] +synonym: "actin modulating activity" RELATED [] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0030029 ! actin filament-based process + +[Term] +id: GO:0030037 +name: actin filament reorganization involved in cell cycle +namespace: biological_process +def: "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] +synonym: "actin filament reorganisation involved in cell cycle" EXACT [GOC:mah] +synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0090527 ! actin filament reorganization + +[Term] +id: GO:0030038 +name: contractile actin filament bundle assembly +namespace: biological_process +def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194] +is_a: GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0030039 +name: obsolete DNA unwinding factor +namespace: molecular_function +alt_id: GO:0017152 +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it does not represent a true molecular function. +synonym: "DNA unwinding factor" EXACT [] +is_obsolete: true +replaced_by: GO:0006268 + +[Term] +id: GO:0030041 +name: actin filament polymerization +namespace: biological_process +def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] +synonym: "actin polymerization" EXACT [] +synonym: "actin polymerizing activity" RELATED [] +is_a: GO:0008154 ! actin polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization + +[Term] +id: GO:0030042 +name: actin filament depolymerization +namespace: biological_process +def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] +synonym: "actin depolymerization" EXACT [] +synonym: "actin depolymerizing activity" RELATED [] +is_a: GO:0008154 ! actin polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization + +[Term] +id: GO:0030043 +name: actin filament fragmentation +namespace: biological_process +def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] +is_a: GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030046 +name: parallel actin filament bundle assembly +namespace: biological_process +def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] +is_a: GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0030047 +name: actin modification +namespace: biological_process +alt_id: GO:0007013 +def: "Covalent modification of an actin molecule." [GOC:mah] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0030048 +name: actin filament-based movement +namespace: biological_process +def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] +is_a: GO:0006928 ! movement of cell or subcellular component +is_a: GO:0030029 ! actin filament-based process + +[Term] +id: GO:0030049 +name: muscle filament sliding +namespace: biological_process +def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194] +is_a: GO:0033275 ! actin-myosin filament sliding +relationship: part_of GO:0006936 ! muscle contraction + +[Term] +id: GO:0030050 +name: vesicle transport along actin filament +namespace: biological_process +def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0099515 ! actin filament-based transport +is_a: GO:0099518 ! vesicle cytoskeletal trafficking + +[Term] +id: GO:0030051 +name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase +namespace: molecular_function +def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product and not a function. +synonym: "FK506 binding protein" RELATED [] +synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" EXACT [] +synonym: "FKBP" RELATED [] +is_obsolete: true +consider: GO:0003755 +consider: GO:0005528 + +[Term] +id: GO:0030052 +name: obsolete parvulin +namespace: molecular_function +def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732] +comment: This term was made obsolete because it describes a gene product. +synonym: "parvulin" EXACT [] +is_obsolete: true +replaced_by: GO:0003755 + +[Term] +id: GO:0030053 +name: obsolete immunophilin +namespace: molecular_function +def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732] +comment: This term was made obsolete because it does not represent a molecular function. +synonym: "immunophilin" EXACT [] +is_obsolete: true +consider: GO:0003755 + +[Term] +id: GO:0030054 +name: cell junction +namespace: cellular_component +def: "A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella." [GOC:aruk, GOC:bc, GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732, PMID:26820516, PMID:28096264] +subset: goslim_agr +subset: goslim_drosophila +subset: goslim_flybase_ribbon +xref: Wikipedia:Cell_junction +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0030055 +name: cell-substrate junction +namespace: cellular_component +def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, GOC:hb, GOC:mah, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] +synonym: "cell-matrix junction" EXACT [] +is_a: GO:0070161 ! anchoring junction + +[Term] +id: GO:0030056 +name: hemidesmosome +namespace: cellular_component +def: "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] +synonym: "epidermal attachment structure" NARROW [GOC:kmv] +synonym: "fibrous organelle" NARROW [GOC:kmv, PMID:20205195] +synonym: "hemi-adherens junction" RELATED [] +synonym: "trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195] +xref: Wikipedia:Hemidesmosome +is_a: GO:0030055 ! cell-substrate junction + +[Term] +id: GO:0030057 +name: desmosome +namespace: cellular_component +def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] +synonym: "macula adherens" EXACT [] +synonym: "spot desmosome" EXACT [] +xref: Wikipedia:Desmosome +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0030058 +name: amine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+." [PMID:6246962, RHEA:51128] +synonym: "amine: (acceptor) oxidoreductase (deaminating)" RELATED [] +synonym: "MADH activity" RELATED [] +synonym: "methylamine dehydrogenase activity" RELATED [] +synonym: "primary-amine dehydrogenase activity" BROAD [] +synonym: "primary-amine:acceptor oxidoreductase (deaminating)" RELATED [] +xref: RHEA:51128 +xref: UM-BBD_enzymeID:e0058 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0030059 +name: aralkylamine dehydrogenase (azurin) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]." [PMID:10506161, RHEA:47796] +synonym: "aralkylamine:(azurin) oxidoreductase (deaminating) activity" EXACT [EC:1.4.9.2] +synonym: "aromatic amine dehydrogenase (azurin) activity" EXACT [EC:1.4.9.2] +xref: EC:1.4.9.2 +xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN +xref: RHEA:47796 +is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor + +[Term] +id: GO:0030060 +name: L-malate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] +synonym: "(S)-malate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.37] +synonym: "L-malate-NAD+ oxidoreductase activity" RELATED [EC:1.1.1.37] +synonym: "malate (NAD) dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "malic acid dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "malic dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "MDH" RELATED [EC:1.1.1.37] +synonym: "NAD-dependent malate dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "NAD-dependent malic dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "NAD-L-malate dehydrogenase activity" EXACT [] +synonym: "NAD-linked malate dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "NAD-malate dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "NAD-malic dehydrogenase activity" RELATED [EC:1.1.1.37] +synonym: "NAD-specific malate dehydrogenase activity" RELATED [EC:1.1.1.37] +xref: EC:1.1.1.37 +xref: MetaCyc:MALATE-DEH-RXN +xref: Reactome:R-HSA-198508 "malate + NAD+ <=> oxaloacetate + NADH + H+" +xref: Reactome:R-HSA-70979 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+" +xref: Reactome:R-HSA-71783 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+" +xref: RHEA:21432 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030061 +name: mitochondrial crista +namespace: cellular_component +def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732] +comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. +synonym: "cristae" BROAD [NIF_Subcellular:sao333328131] +synonym: "mitochondrial cristae" EXACT [] +xref: NIF_Subcellular:sao333328131 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0030062 +name: mitochondrial tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] +synonym: "TCA cycle enzyme complex" BROAD [] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0030063 +name: obsolete murein sacculus +namespace: cellular_component +def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "murein sacculus" EXACT [] +synonym: "peptidoglycan layer" EXACT [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0030064 +name: obsolete cell wall inner membrane +namespace: cellular_component +def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254] +comment: This term was made obsolete because it was defined inaccurately. +synonym: "cell wall inner membrane" EXACT [] +is_obsolete: true +consider: GO:0009276 + +[Term] +id: GO:0030066 +name: obsolete cytochrome b6 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytochrome b-563" RELATED [] +synonym: "cytochrome b6" EXACT [] +is_obsolete: true +replaced_by: GO:0045158 + +[Term] +id: GO:0030067 +name: obsolete respiratory chain cytochrome b6 +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "respiratory chain cytochrome b6" EXACT [] +is_obsolete: true +consider: GO:0009055 + +[Term] +id: GO:0030068 +name: obsolete lytic viral life cycle +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because more specific terms were created. +synonym: "lytic viral life cycle" EXACT [] +is_obsolete: true +consider: GO:0019058 +consider: GO:0044659 + +[Term] +id: GO:0030070 +name: insulin processing +namespace: biological_process +def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732] +is_a: GO:0016486 ! peptide hormone processing +is_a: GO:1901142 ! insulin metabolic process + +[Term] +id: GO:0030071 +name: regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah] +is_a: GO:0010965 ! regulation of mitotic sister chromatid separation +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle +relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle + +[Term] +id: GO:0030072 +name: peptide hormone secretion +namespace: biological_process +def: "The regulated release of a peptide hormone from a cell." [GOC:mah] +is_a: GO:0002790 ! peptide secretion +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0030073 +name: insulin secretion +namespace: biological_process +def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] +is_a: GO:0009306 ! protein secretion +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030074 +name: obsolete thylakoid (sensu Proteobacteria) +namespace: cellular_component +def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah] +comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. +synonym: "thylakoid (sensu Proteobacteria)" EXACT [] +is_obsolete: true +consider: GO:0042716 + +[Term] +id: GO:0030075 +name: bacterial thylakoid +namespace: cellular_component +def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] +synonym: "plasma membrane-derived thylakoid" EXACT [] +is_a: GO:0009579 ! thylakoid +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0030076 +name: light-harvesting complex +namespace: cellular_component +def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] +subset: goslim_pir +synonym: "antenna complex" RELATED [] +xref: Wikipedia:Light-harvesting_complex +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0030077 +name: plasma membrane light-harvesting complex +namespace: cellular_component +def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0030076 ! light-harvesting complex +relationship: part_of GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0030078 +name: light-harvesting complex, core complex +namespace: cellular_component +def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] +is_a: GO:0030077 ! plasma membrane light-harvesting complex + +[Term] +id: GO:0030079 +name: light-harvesting complex, peripheral complex +namespace: cellular_component +def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] +is_a: GO:0030077 ! plasma membrane light-harvesting complex + +[Term] +id: GO:0030080 +name: B875 antenna complex +namespace: cellular_component +def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] +synonym: "LH1 complex" EXACT [] +synonym: "light harvesting complex I" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030078 ! light-harvesting complex, core complex + +[Term] +id: GO:0030081 +name: B800-820 antenna complex +namespace: cellular_component +def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] +synonym: "LH3 complex" EXACT [] +synonym: "light harvesting complex III" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex + +[Term] +id: GO:0030082 +name: B800-850 antenna complex +namespace: cellular_component +def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] +synonym: "LH2 complex" EXACT [] +synonym: "light harvesting complex II" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex + +[Term] +id: GO:0030083 +name: PSI associated light-harvesting complex I, LHCIa subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] +is_a: GO:0009518 ! PSI associated light-harvesting complex I + +[Term] +id: GO:0030084 +name: PSI associated light-harvesting complex I, LHCIb subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] +is_a: GO:0009518 ! PSI associated light-harvesting complex I + +[Term] +id: GO:0030085 +name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex +namespace: cellular_component +def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex +relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex + +[Term] +id: GO:0030086 +name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" EXACT [] +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030087 +name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" EXACT [] +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030088 +name: obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex +namespace: cellular_component +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. +synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" EXACT [] +is_obsolete: true +replaced_by: GO:0009655 + +[Term] +id: GO:0030089 +name: phycobilisome +namespace: cellular_component +def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome] +xref: Wikipedia:Phycobilisome +is_a: GO:0030076 ! light-harvesting complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0030091 +name: protein repair +namespace: biological_process +def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0030092 +name: obsolete regulation of flagellum assembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "regulation of flagella assembly" RELATED [GOC:mah] +synonym: "regulation of flagella biogenesis" RELATED [] +synonym: "regulation of flagellum assembly" EXACT [] +synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah] +is_obsolete: true +consider: GO:1902017 +consider: GO:1902208 + +[Term] +id: GO:0030093 +name: chloroplast photosystem I +namespace: cellular_component +def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] +is_a: GO:0009522 ! photosystem I +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex + +[Term] +id: GO:0030094 +name: plasma membrane-derived photosystem I +namespace: cellular_component +def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu] +synonym: "plasma membrane photosystem I" EXACT [] +is_a: GO:0009522 ! photosystem I +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0030075 ! bacterial thylakoid + +[Term] +id: GO:0030095 +name: chloroplast photosystem II +namespace: cellular_component +def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] +is_a: GO:0009523 ! photosystem II +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex + +[Term] +id: GO:0030096 +name: plasma membrane-derived thylakoid photosystem II +namespace: cellular_component +def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] +synonym: "plasma membrane photosystem II" EXACT [] +is_a: GO:0009523 ! photosystem II +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0030075 ! bacterial thylakoid + +[Term] +id: GO:0030097 +name: hemopoiesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] +synonym: "blood cell biosynthesis" EXACT [] +synonym: "blood cell formation" EXACT [] +synonym: "haemopoiesis" EXACT [] +synonym: "hematopoiesis" EXACT [] +xref: Wikipedia:Haematopoiesis +is_a: GO:0048534 ! hematopoietic or lymphoid organ development + +[Term] +id: GO:0030098 +name: lymphocyte differentiation +namespace: biological_process +alt_id: GO:0046650 +def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "lymphocyte cell differentiation" EXACT [] +synonym: "lymphocyte development" RELATED [GOC:add] +synonym: "lymphocytic blood cell differentiation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation +is_a: GO:1903131 ! mononuclear cell differentiation + +[Term] +id: GO:0030099 +name: myeloid cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0030100 +name: regulation of endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0030101 +name: natural killer cell activation +namespace: biological_process +def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] +synonym: "NK cell activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0030103 +name: vasopressin secretion +namespace: biological_process +def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030104 +name: water homeostasis +namespace: biological_process +alt_id: GO:0018987 +def: "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] +synonym: "osmoregulation" RELATED [] +synonym: "regulation of osmotic pressure" EXACT [] +xref: Wikipedia:Osmoregulation +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0030105 +name: obsolete anaphylaxis +namespace: biological_process +def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732] +comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism. +synonym: "anaphylaxis" EXACT [] +is_obsolete: true +consider: GO:0006955 + +[Term] +id: GO:0030106 +name: obsolete MHC class I receptor activity +namespace: molecular_function +def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971] +comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'. +synonym: "class I major histocompatibility complex antigen" RELATED [] +synonym: "major histocompatibility complex class I receptor" EXACT [] +synonym: "MHC class I receptor activity" EXACT [] +is_obsolete: true +consider: GO:0032393 +consider: GO:0042612 + +[Term] +id: GO:0030107 +name: HLA-A specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030108 +name: HLA-A specific activating MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032397 ! activating MHC class I receptor activity + +[Term] +id: GO:0030109 +name: HLA-B specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030110 +name: HLA-C specific inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] +is_a: GO:0032396 ! inhibitory MHC class I receptor activity + +[Term] +id: GO:0030111 +name: regulation of Wnt signaling pathway +namespace: biological_process +alt_id: GO:0008590 +def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of frizzled signaling pathway" EXACT [] +synonym: "regulation of frizzled signalling pathway" EXACT [] +synonym: "regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway" EXACT [] +synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0016055 ! Wnt signaling pathway + +[Term] +id: GO:0030112 +name: glycocalyx +namespace: cellular_component +def: "A carbohydrate rich layer at the outermost periphery of a cell." [GOC:krc, GOC:mlg, ISBN:0815316208, PMID:28876829] +subset: goslim_pir +xref: Wikipedia:Glycocalyx +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0030114 +name: slime layer +namespace: cellular_component +def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer] +xref: Wikipedia:Slime_layer +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0030115 +name: S-layer +namespace: cellular_component +def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] +subset: goslim_pir +xref: Wikipedia:S-layer +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0030116 +name: glial cell-derived neurotrophic factor receptor binding +namespace: molecular_function +def: "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867] +synonym: "glial cell line-derived neurotrophic factor receptor binding" RELATED [] +synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0030117 +name: membrane coat +namespace: cellular_component +def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0048475 ! coated membrane + +[Term] +id: GO:0030118 +name: clathrin coat +namespace: cellular_component +alt_id: GO:0016190 +def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] +synonym: "clathrin cage" EXACT [] +xref: NIF_Subcellular:sao879919129 +xref: Wikipedia:Clathrin +is_a: GO:0030117 ! membrane coat + +[Term] +id: GO:0030119 +name: AP-type membrane coat adaptor complex +namespace: cellular_component +def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] +subset: goslim_pir +synonym: "clathrin adaptor" RELATED [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0030117 ! membrane coat + +[Term] +id: GO:0030120 +name: vesicle coat +namespace: cellular_component +def: "A membrane coat found on a coated vesicle." [GOC:mah] +xref: NIF_Subcellular:sao1177708494 +is_a: GO:0030117 ! membrane coat +relationship: part_of GO:0030662 ! coated vesicle membrane + +[Term] +id: GO:0030121 +name: AP-1 adaptor complex +namespace: cellular_component +def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] +synonym: "AP-1 related adapter complex" RELATED [] +synonym: "HA1" EXACT [] +synonym: "HA1 clathrin adaptor" EXACT [] +is_a: GO:0030131 ! clathrin adaptor complex +relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle + +[Term] +id: GO:0030122 +name: AP-2 adaptor complex +namespace: cellular_component +def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426] +synonym: "HA2" EXACT [] +synonym: "HA2 clathrin adaptor" EXACT [] +is_a: GO:0030131 ! clathrin adaptor complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle +relationship: part_of GO:0030132 ! clathrin coat of coated pit + +[Term] +id: GO:0030123 +name: AP-3 adaptor complex +namespace: cellular_component +def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex + +[Term] +id: GO:0030124 +name: AP-4 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex + +[Term] +id: GO:0030125 +name: clathrin vesicle coat +namespace: cellular_component +def: "A clathrin coat found on a vesicle." [GOC:mah] +is_a: GO:0030118 ! clathrin coat +is_a: GO:0030120 ! vesicle coat +relationship: part_of GO:0030665 ! clathrin-coated vesicle membrane + +[Term] +id: GO:0030126 +name: COPI vesicle coat +namespace: cellular_component +alt_id: GO:0017167 +def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] +synonym: "coatomer" EXACT [] +is_a: GO:0030120 ! vesicle coat +relationship: part_of GO:0005794 ! Golgi apparatus +relationship: part_of GO:0030663 ! COPI-coated vesicle membrane + +[Term] +id: GO:0030127 +name: COPII vesicle coat +namespace: cellular_component +def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] +is_a: GO:0030120 ! vesicle coat +relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane + +[Term] +id: GO:0030128 +name: clathrin coat of endocytic vesicle +namespace: cellular_component +def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] +synonym: "clathrin coat of endocytotic vesicle" EXACT [] +is_a: GO:0030125 ! clathrin vesicle coat +relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane + +[Term] +id: GO:0030129 +name: clathrin coat of synaptic vesicle +namespace: cellular_component +def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] +is_a: GO:0030125 ! clathrin vesicle coat +relationship: part_of GO:0030672 ! synaptic vesicle membrane + +[Term] +id: GO:0030130 +name: clathrin coat of trans-Golgi network vesicle +namespace: cellular_component +def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] +synonym: "clathrin coat of TGN vesicle" EXACT [] +is_a: GO:0030125 ! clathrin vesicle coat +relationship: part_of GO:0005794 ! Golgi apparatus +relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane + +[Term] +id: GO:0030131 +name: clathrin adaptor complex +namespace: cellular_component +def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex +relationship: part_of GO:0030118 ! clathrin coat + +[Term] +id: GO:0030132 +name: clathrin coat of coated pit +namespace: cellular_component +def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] +is_a: GO:0030118 ! clathrin coat +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005905 ! clathrin-coated pit + +[Term] +id: GO:0030133 +name: transport vesicle +namespace: cellular_component +def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] +comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. +synonym: "constitutive secretory pathway transport vesicle" EXACT [] +synonym: "Golgi to vacuole transport vesicle" NARROW [] +synonym: "Golgi-vacuole transport vesicle" NARROW [] +synonym: "secretory vesicle" RELATED [] +xref: NIF_Subcellular:sao885490876 +is_a: GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0030134 +name: COPII-coated ER to Golgi transport vesicle +namespace: cellular_component +alt_id: GO:0030138 +alt_id: GO:0140045 +def: "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII] +synonym: "COPII vesicle" RELATED [] +synonym: "COPII-associated ER to Golgi transport vesicle" EXACT [] +synonym: "COPII-associated vesicle" EXACT [] +synonym: "COPII-coated vesicle" EXACT [] +synonym: "endoplasmic reticulum to Golgi transport vesicle" RELATED [] +synonym: "endoplasmic reticulum-Golgi transport vesicle" RELATED [] +synonym: "ER to Golgi constitutive secretory pathway transport vesicle" RELATED [] +synonym: "ER to Golgi transport vesicle" RELATED [] +synonym: "ER-Golgi transport vesicle" RELATED [] +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030135 +name: coated vesicle +namespace: cellular_component +alt_id: GO:0005909 +def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] +subset: goslim_drosophila +xref: NIF_Subcellular:sao1985096626 +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0030136 +name: clathrin-coated vesicle +namespace: cellular_component +def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] +xref: NIF_Subcellular:sao148845161 +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030137 +name: COPI-coated vesicle +namespace: cellular_component +def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] +synonym: "coatomer" RELATED [] +is_a: GO:0005798 ! Golgi-associated vesicle +is_a: GO:0030135 ! coated vesicle + +[Term] +id: GO:0030139 +name: endocytic vesicle +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] +synonym: "endocytotic transport vesicle" EXACT [] +synonym: "endocytotic vesicle" EXACT [] +xref: NIF_Subcellular:sao1362520468 +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0030140 +name: trans-Golgi network transport vesicle +namespace: cellular_component +def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] +synonym: "TGN transport vesicle" EXACT [] +synonym: "trans-Golgi network constitutive secretory pathway transport vesicle" EXACT [] +is_a: GO:0005798 ! Golgi-associated vesicle +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0030141 +name: secretory granule +namespace: cellular_component +def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198506732] +comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. +synonym: "secretory vesicle" BROAD [] +is_a: GO:0099503 ! secretory vesicle +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0030142 +name: COPI-coated Golgi to ER transport vesicle +namespace: cellular_component +def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157] +synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] +synonym: "Golgi to ER constitutive secretory pathway transport vesicle" EXACT [] +synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] +synonym: "Golgi-ER transport vesicle" EXACT [] +synonym: "retrograde transport vesicle" EXACT [PMID:22160157] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030143 +name: COPI-coated inter-Golgi transport vesicle +namespace: cellular_component +alt_id: GO:0005807 +def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] +synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle" EXACT [] +xref: NIF_Subcellular:sao1382918459 +is_a: GO:0030133 ! transport vesicle +is_a: GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030144 +name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] +synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155] +synonym: "GnTV activity" RELATED [EC:2.4.1.155] +synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] +synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.155] +synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155] +synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155] +synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155] +synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.155] +xref: EC:2.4.1.155 +xref: MetaCyc:2.4.1.155-RXN +xref: Reactome:R-HSA-9696980 "Spike trimer glycoside chains get additional branches" +xref: Reactome:R-HSA-975916 "Addition of GlcNAc to position 5 by MGAT5" +xref: RHEA:16921 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0030145 +name: manganese ion binding +namespace: molecular_function +def: "Binding to a manganese ion (Mn)." [GOC:ai] +synonym: "manganese binding" EXACT [] +synonym: "Mn binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0030146 +name: obsolete diuresis +namespace: biological_process +alt_id: GO:0003076 +def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "diuresis" EXACT [] +synonym: "positive regulation of renal water excretion" EXACT [] +synonym: "renal water excretion" BROAD [] +xref: Wikipedia:Diuresis +is_obsolete: true +consider: GO:0035810 + +[Term] +id: GO:0030147 +name: obsolete natriuresis +namespace: biological_process +def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732] +comment: This term was made obsolete because its definition was inaccurate. +synonym: "natriuresis" EXACT [] +xref: Wikipedia:Natriuresis +is_obsolete: true +consider: GO:0035815 + +[Term] +id: GO:0030148 +name: sphingolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] +synonym: "sphingolipid anabolism" EXACT [] +synonym: "sphingolipid biosynthesis" EXACT [] +synonym: "sphingolipid formation" EXACT [] +synonym: "sphingolipid synthesis" EXACT [] +xref: MetaCyc:PWY-5129 +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0046467 ! membrane lipid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0030149 +name: sphingolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] +synonym: "sphingolipid breakdown" EXACT [] +synonym: "sphingolipid catabolism" EXACT [] +synonym: "sphingolipid degradation" EXACT [] +is_a: GO:0006665 ! sphingolipid metabolic process +is_a: GO:0046466 ! membrane lipid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0030150 +name: protein import into mitochondrial matrix +namespace: biological_process +def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] +synonym: "mitochondrial matrix protein import" EXACT [] +synonym: "mitochondrial translocation" BROAD [] +synonym: "protein transport into mitochondrial matrix" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0044743 ! protein transmembrane import into intracellular organelle +is_a: GO:0065002 ! intracellular protein transmembrane transport +is_a: GO:0072655 ! establishment of protein localization to mitochondrion +is_a: GO:1990542 ! mitochondrial transmembrane transport +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0030151 +name: molybdenum ion binding +namespace: molecular_function +def: "Binding to a molybdenum ion (Mo)." [GOC:ai] +synonym: "Mo ion binding" EXACT [] +synonym: "molybdenum binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0030152 +name: bacteriocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] +synonym: "bacteriocin anabolism" EXACT [] +synonym: "bacteriocin biosynthesis" EXACT [] +synonym: "bacteriocin formation" EXACT [] +synonym: "bacteriocin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0030651 ! peptide antibiotic biosynthetic process +is_a: GO:0046224 ! bacteriocin metabolic process + +[Term] +id: GO:0030153 +name: bacteriocin immunity +namespace: biological_process +def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] +is_a: GO:0009404 ! toxin metabolic process + +[Term] +id: GO:0030154 +name: cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_mouse +subset: goslim_plant +xref: Wikipedia:Cellular_differentiation +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0030155 +name: regulation of cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] +synonym: "cell adhesion receptor regulator activity" RELATED [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0030156 +name: benzodiazepine receptor binding +namespace: molecular_function +def: "Binding to a peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] +synonym: "benzodiazepine receptor ligand" NARROW [] +synonym: "diazepam binding inhibitor activity" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0030157 +name: pancreatic juice secretion +namespace: biological_process +def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0022600 ! digestive system process +is_a: GO:0032941 ! secretion by tissue + +[Term] +id: GO:0030158 +name: protein xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] +synonym: "peptide O-xylosyltransferase activity" EXACT [] +synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "UDP-D-xylose:core protein xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" RELATED [EC:2.4.2.26] +synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" RELATED [EC:2.4.2.26] +xref: EC:2.4.2.26 +xref: MetaCyc:2.4.2.26-RXN +xref: Reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein" +xref: RHEA:50192 +is_a: GO:0035252 ! UDP-xylosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0030159 +name: signaling receptor complex adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] +synonym: "receptor signaling complex adaptor activity" EXACT [] +synonym: "receptor signaling complex scaffold activity" EXACT [] +synonym: "receptor signaling complex scaffold protein activity" EXACT [] +synonym: "receptor signalling complex adaptor activity" EXACT [] +synonym: "receptor signalling complex scaffold activity" EXACT [] +is_a: GO:0035591 ! signaling adaptor activity + +[Term] +id: GO:0030160 +name: synaptic receptor adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule." [PMID:10506216] +synonym: "GKAP/Homer scaffold activity" NARROW [] +synonym: "GKAP/Homer scaffold protein" NARROW [] +synonym: "postsynaptic density scaffold protein" NARROW [] +is_a: GO:0030159 ! signaling receptor complex adaptor activity + +[Term] +id: GO:0030161 +name: obsolete calpain inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] +comment: This term was made obsolete because it represents a regulator of a non-existent molecular function. +synonym: "calpain inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0010859 + +[Term] +id: GO:0030162 +name: regulation of proteolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] +synonym: "regulation of peptidolysis" EXACT [] +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0030163 +name: protein catabolic process +namespace: biological_process +alt_id: GO:0044254 +def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] +comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +synonym: "multicellular organismal protein catabolic process" NARROW [] +synonym: "pheromone catabolic process" RELATED [] +synonym: "pheromone catabolism" RELATED [] +synonym: "protein breakdown" EXACT [] +synonym: "protein catabolism" EXACT [] +synonym: "protein degradation" EXACT [] +xref: Wikipedia:Protein_catabolism +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0019538 ! protein metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0030164 +name: protein denaturation +namespace: biological_process +def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359] +xref: Wikipedia:Denaturation#Protein_denaturation +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0030165 +name: PDZ domain binding +namespace: molecular_function +def: "Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] +synonym: "DHR-domain binding" EXACT [] +synonym: "GLGF-domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030166 +name: proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] +synonym: "proteoglycan anabolism" EXACT [] +synonym: "proteoglycan biosynthesis" EXACT [] +synonym: "proteoglycan formation" EXACT [] +synonym: "proteoglycan synthesis" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0030167 +name: proteoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] +synonym: "proteoglycan breakdown" EXACT [] +synonym: "proteoglycan catabolism" EXACT [] +synonym: "proteoglycan degradation" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process +is_a: GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0030168 +name: platelet activation +namespace: biological_process +def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] +synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0007596 ! blood coagulation + +[Term] +id: GO:0030169 +name: low-density lipoprotein particle binding +namespace: molecular_function +def: "Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] +subset: goslim_chembl +synonym: "LDL binding" EXACT [] +is_a: GO:0071813 ! lipoprotein particle binding + +[Term] +id: GO:0030170 +name: pyridoxal phosphate binding +namespace: molecular_function +def: "Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] +subset: goslim_metagenomics +is_a: GO:0043168 ! anion binding +is_a: GO:0070279 ! vitamin B6 binding + +[Term] +id: GO:0030171 +name: voltage-gated proton channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:28774948] +synonym: "voltage gated proton channel activity" EXACT [] +synonym: "voltage-dependent proton channel activity" EXACT [] +is_a: GO:0015252 ! proton channel activity +is_a: GO:0022843 ! voltage-gated cation channel activity + +[Term] +id: GO:0030172 +name: troponin C binding +namespace: molecular_function +def: "Binding to troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0030173 +name: integral component of Golgi membrane +namespace: cellular_component +def: "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] +synonym: "Golgi integral membrane protein" RELATED [] +synonym: "integral to Golgi membrane" NARROW [] +is_a: GO:0031228 ! intrinsic component of Golgi membrane +is_a: GO:0031301 ! integral component of organelle membrane + +[Term] +id: GO:0030174 +name: regulation of DNA-dependent DNA replication initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] +synonym: "DNA replication licencing" EXACT [] +synonym: "DNA replication licensing" EXACT [] +synonym: "regulation of DNA replication initiation" BROAD [GOC:vw] +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0030175 +name: filopodium +namespace: cellular_component +alt_id: GO:0030028 +def: "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] +comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. +subset: goslim_pir +xref: NIF_Subcellular:sao1046371754 +xref: Wikipedia:Filopodia +is_a: GO:0098858 ! actin-based cell projection + +[Term] +id: GO:0030176 +name: integral component of endoplasmic reticulum membrane +namespace: cellular_component +def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "ER integral membrane protein" EXACT [] +synonym: "integral to endoplasmic reticulum membrane" NARROW [] +synonym: "integral to ER membrane" EXACT [] +is_a: GO:0031227 ! intrinsic component of endoplasmic reticulum membrane +is_a: GO:0031301 ! integral component of organelle membrane + +[Term] +id: GO:0030177 +name: positive regulation of Wnt signaling pathway +namespace: biological_process +alt_id: GO:0045811 +def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of frizzled signaling pathway" NARROW [] +synonym: "activation of Wnt receptor signaling pathway" NARROW [] +synonym: "positive regulation of frizzled signaling pathway" EXACT [] +synonym: "positive regulation of frizzled signalling pathway" EXACT [] +synonym: "positive regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] +synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "stimulation of frizzled signaling pathway" NARROW [] +synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] +synonym: "up regulation of frizzled signaling pathway" EXACT [] +synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "up-regulation of frizzled signaling pathway" EXACT [] +synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "upregulation of frizzled signaling pathway" EXACT [] +synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: positively_regulates GO:0016055 ! Wnt signaling pathway + +[Term] +id: GO:0030178 +name: negative regulation of Wnt signaling pathway +namespace: biological_process +alt_id: GO:0045810 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of frizzled signaling pathway" EXACT [] +synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "down-regulation of frizzled signaling pathway" EXACT [] +synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "downregulation of frizzled signaling pathway" EXACT [] +synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] +synonym: "inhibition of frizzled signaling pathway" NARROW [] +synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] +synonym: "negative regulation of frizzled signaling pathway" EXACT [] +synonym: "negative regulation of frizzled signalling pathway" EXACT [] +synonym: "negative regulation of Wnt receptor signaling pathway" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] +synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway + +[Term] +id: GO:0030180 +name: obsolete solute:solute exchange +namespace: biological_process +def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah] +comment: This term was made obsolete because it represents a molecular function. +synonym: "solute:solute exchange" EXACT [] +is_obsolete: true +consider: GO:0006810 +consider: GO:0015297 + +[Term] +id: GO:0030181 +name: obsolete sodium:calcium exchange +namespace: biological_process +def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732] +comment: This term was made obsolete because it represents a function rather than a process. +synonym: "sodium:calcium exchange" EXACT [] +is_obsolete: true +consider: GO:0005432 +consider: GO:0006814 +consider: GO:0006816 + +[Term] +id: GO:0030182 +name: neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048699 ! generation of neurons + +[Term] +id: GO:0030183 +name: B cell differentiation +namespace: biological_process +alt_id: GO:0042115 +def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "B cell development" RELATED [GOC:add] +synonym: "B lymphocyte differentiation" EXACT [] +synonym: "B-cell differentiation" EXACT [] +synonym: "B-lymphocyte differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0042113 ! B cell activation + +[Term] +id: GO:0030184 +name: nitric oxide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0030185 +name: nitric oxide transport +namespace: biological_process +def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0030186 +name: melatonin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] +synonym: "melatonin metabolism" EXACT [] +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0030187 +name: melatonin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] +synonym: "melatonin anabolism" EXACT [] +synonym: "melatonin biosynthesis" EXACT [] +synonym: "melatonin formation" EXACT [] +synonym: "melatonin synthesis" EXACT [] +is_a: GO:0030186 ! melatonin metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0030188 +name: obsolete chaperone regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah] +comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. +synonym: "chaperone regulator activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0030189 +name: obsolete chaperone activator activity +namespace: molecular_function +def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah] +comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. +synonym: "chaperone activator activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0030190 +name: obsolete chaperone inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] +comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. +synonym: "chaperone inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0030191 +name: obsolete Hsp70/Hsc70 protein inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. +synonym: "Hsp70/Hsc70 protein inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0030192 +name: obsolete Hsp70/Hsc70 protein regulator activity +namespace: molecular_function +def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. +synonym: "Hsp70/Hsc70 protein regulator activity" EXACT [] +is_obsolete: true +consider: GO:0006457 +consider: GO:0051082 +consider: GO:0051787 + +[Term] +id: GO:0030193 +name: regulation of blood coagulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0050818 ! regulation of coagulation +is_a: GO:0061041 ! regulation of wound healing +is_a: GO:1900046 ! regulation of hemostasis +relationship: regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030194 +name: positive regulation of blood coagulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] +synonym: "activation of blood coagulation" NARROW [] +synonym: "stimulation of blood coagulation" NARROW [] +synonym: "up regulation of blood coagulation" EXACT [] +synonym: "up-regulation of blood coagulation" EXACT [] +synonym: "upregulation of blood coagulation" EXACT [] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0050820 ! positive regulation of coagulation +is_a: GO:0090303 ! positive regulation of wound healing +is_a: GO:1900048 ! positive regulation of hemostasis +relationship: positively_regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030195 +name: negative regulation of blood coagulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] +synonym: "down regulation of blood coagulation" EXACT [] +synonym: "down-regulation of blood coagulation" EXACT [] +synonym: "downregulation of blood coagulation" EXACT [] +synonym: "inhibition of blood coagulation" NARROW [] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0050819 ! negative regulation of coagulation +is_a: GO:0061045 ! negative regulation of wound healing +is_a: GO:1900047 ! negative regulation of hemostasis +relationship: negatively_regulates GO:0007596 ! blood coagulation + +[Term] +id: GO:0030196 +name: cyanide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21720] +synonym: "formamide dehydratase activity" RELATED [EC:4.2.1.66] +synonym: "formamide hydro-lyase (cyanide-forming)" RELATED [EC:4.2.1.66] +synonym: "formamide hydro-lyase activity" RELATED [EC:4.2.1.66] +xref: EC:4.2.1.66 +xref: KEGG_REACTION:R01408 +xref: MetaCyc:CYANIDE-HYDRATASE-RXN +xref: RHEA:21720 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0030197 +name: extracellular matrix constituent, lubricant activity +namespace: molecular_function +def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] +comment: Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586 +synonym: "core extracellular matrix" BROAD [] +synonym: "core matrisome" BROAD [] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0030198 +name: extracellular matrix organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +synonym: "extracellular matrix organisation" EXACT [] +synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0043062 ! extracellular structure organization +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0030199 +name: collagen fibril organization +namespace: biological_process +def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] +synonym: "collagen fibril organisation" EXACT [] +synonym: "fibrillar collagen organization" EXACT [GOC:mah] +is_a: GO:0030198 ! extracellular matrix organization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0030200 +name: heparan sulfate proteoglycan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] +synonym: "heparan sulfate proteoglycan breakdown" EXACT [] +synonym: "heparan sulfate proteoglycan catabolism" EXACT [] +synonym: "heparan sulfate proteoglycan degradation" EXACT [] +synonym: "heparan sulphate proteoglycan catabolic process" EXACT [] +synonym: "heparan sulphate proteoglycan catabolism" EXACT [] +synonym: "heparin proteoglycan catabolic process" RELATED [] +is_a: GO:0030167 ! proteoglycan catabolic process +is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process + +[Term] +id: GO:0030201 +name: heparan sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] +synonym: "heparan sulfate proteoglycan metabolism" EXACT [] +synonym: "heparan sulphate proteoglycan metabolic process" EXACT [] +synonym: "heparan sulphate proteoglycan metabolism" EXACT [] +synonym: "heparin proteoglycan metabolic process" RELATED [] +is_a: GO:0006029 ! proteoglycan metabolic process + +[Term] +id: GO:0030202 +name: heparin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] +synonym: "heparan sulfate metabolic process" RELATED [] +synonym: "heparin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1903510 ! mucopolysaccharide metabolic process + +[Term] +id: GO:0030203 +name: glycosaminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] +synonym: "glycosaminoglycan metabolism" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process + +[Term] +id: GO:0030204 +name: chondroitin sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate metabolism" EXACT [] +synonym: "chondroitin sulphate metabolic process" EXACT [] +synonym: "chondroitin sulphate metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1903510 ! mucopolysaccharide metabolic process +relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process + +[Term] +id: GO:0030205 +name: dermatan sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate B metabolic process" EXACT [] +synonym: "chondroitin sulfate B metabolism" EXACT [] +synonym: "dermatan sulfate metabolism" EXACT [] +synonym: "dermatan sulphate metabolic process" EXACT [] +synonym: "dermatan sulphate metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1903510 ! mucopolysaccharide metabolic process +relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process + +[Term] +id: GO:0030206 +name: chondroitin sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate anabolism" EXACT [] +synonym: "chondroitin sulfate biosynthesis" EXACT [] +synonym: "chondroitin sulfate formation" EXACT [] +synonym: "chondroitin sulfate synthesis" EXACT [] +synonym: "chondroitin sulphate biosynthesis" EXACT [] +synonym: "chondroitin sulphate biosynthetic process" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030204 ! chondroitin sulfate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0030207 +name: chondroitin sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate breakdown" EXACT [] +synonym: "chondroitin sulfate catabolism" EXACT [] +synonym: "chondroitin sulfate degradation" EXACT [] +synonym: "chondroitin sulphate catabolic process" EXACT [] +synonym: "chondroitin sulphate catabolism" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030204 ! chondroitin sulfate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0030208 +name: dermatan sulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate B biosynthesis" EXACT [] +synonym: "chondroitin sulfate B biosynthetic process" EXACT [] +synonym: "dermatan sulfate anabolism" EXACT [] +synonym: "dermatan sulfate biosynthesis" EXACT [] +synonym: "dermatan sulfate formation" EXACT [] +synonym: "dermatan sulfate synthesis" EXACT [] +synonym: "dermatan sulphate biosynthesis" EXACT [] +synonym: "dermatan sulphate biosynthetic process" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030205 ! dermatan sulfate metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0030209 +name: dermatan sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] +synonym: "chondroitin sulfate B catabolic process" EXACT [] +synonym: "chondroitin sulfate B catabolism" EXACT [] +synonym: "dermatan sulfate breakdown" EXACT [] +synonym: "dermatan sulfate catabolism" EXACT [] +synonym: "dermatan sulfate degradation" EXACT [] +synonym: "dermatan sulphate catabolic process" EXACT [] +synonym: "dermatan sulphate catabolism" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030205 ! dermatan sulfate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0030210 +name: heparin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] +synonym: "heparan sulfate biosynthetic process" RELATED [] +synonym: "heparin anabolism" EXACT [] +synonym: "heparin biosynthesis" EXACT [] +synonym: "heparin formation" EXACT [] +synonym: "heparin synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030202 ! heparin metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0030211 +name: heparin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] +synonym: "heparan sulfate catabolic process" RELATED [] +synonym: "heparin breakdown" EXACT [] +synonym: "heparin catabolism" EXACT [] +synonym: "heparin degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030202 ! heparin metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0030212 +name: hyaluronan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] +synonym: "hyaluronan metabolism" EXACT [] +is_a: GO:1903510 ! mucopolysaccharide metabolic process + +[Term] +id: GO:0030213 +name: hyaluronan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] +synonym: "hyaluronan anabolism" EXACT [] +synonym: "hyaluronan biosynthesis" EXACT [] +synonym: "hyaluronan formation" EXACT [] +synonym: "hyaluronan synthesis" EXACT [] +is_a: GO:0006024 ! glycosaminoglycan biosynthetic process +is_a: GO:0030212 ! hyaluronan metabolic process + +[Term] +id: GO:0030214 +name: hyaluronan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] +synonym: "hyaluronan breakdown" EXACT [] +synonym: "hyaluronan catabolism" EXACT [] +synonym: "hyaluronan degradation" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0030212 ! hyaluronan metabolic process + +[Term] +id: GO:0030215 +name: semaphorin receptor binding +namespace: molecular_function +def: "Binding to a semaphorin receptor." [GOC:ceb, PMID:12001990] +synonym: "plexin binding" NARROW [] +synonym: "plexin ligand" NARROW [] +synonym: "semaphorin receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0030216 +name: keratinocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] +synonym: "keratinocyte cell differentiation" EXACT [] +is_a: GO:0009913 ! epidermal cell differentiation +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0030217 +name: T cell differentiation +namespace: biological_process +alt_id: GO:0042112 +alt_id: GO:0046652 +def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah] +comment: Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T cell development" RELATED [GOC:add] +synonym: "T lymphocyte differentiation" EXACT [] +synonym: "T-cell differentiation" EXACT [] +synonym: "T-lymphocyte differentiation" EXACT [] +is_a: GO:0030098 ! lymphocyte differentiation +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0030218 +name: erythrocyte differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] +synonym: "erythrocyte cell differentiation" EXACT [] +synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] +synonym: "RBC differentiation" EXACT [CL:0000232] +synonym: "red blood cell differentiation" EXACT [CL:0000232] +xref: Wikipedia:Erythropoiesis +is_a: GO:0030099 ! myeloid cell differentiation +relationship: part_of GO:0034101 ! erythrocyte homeostasis + +[Term] +id: GO:0030219 +name: megakaryocyte differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] +synonym: "megakaryocyte cell differentiation" EXACT [] +is_a: GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0030220 +name: platelet formation +namespace: biological_process +def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] +synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators] +is_a: GO:0030099 ! myeloid cell differentiation +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0036344 ! platelet morphogenesis + +[Term] +id: GO:0030221 +name: basophil differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah] +synonym: "basophil cell differentiation" EXACT [] +is_a: GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030222 +name: eosinophil differentiation +namespace: biological_process +alt_id: GO:0035856 +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah] +synonym: "eosinophil cell development" RELATED [GOC:bf] +synonym: "eosinophil cell differentiation" EXACT [] +synonym: "eosinophil development" RELATED [] +is_a: GO:0030851 ! granulocyte differentiation +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0030223 +name: neutrophil differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] +synonym: "neutrophil cell differentiation" EXACT [] +synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf] +synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf] +is_a: GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030224 +name: monocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] +synonym: "monocyte cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation +is_a: GO:1903131 ! mononuclear cell differentiation + +[Term] +id: GO:0030225 +name: macrophage differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] +synonym: "macrophage cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030226 +name: apolipoprotein receptor activity +namespace: molecular_function +def: "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0030227 +name: obsolete apolipoprotein E receptor activity +namespace: molecular_function +def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] +comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). +synonym: "ApoE receptor" EXACT [] +synonym: "apolipoprotein E receptor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030229 + +[Term] +id: GO:0030228 +name: lipoprotein particle receptor activity +namespace: molecular_function +def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:bf, GOC:mah, PMID:12827279] +comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'. +synonym: "lipoprotein receptor activity" EXACT [GOC:dph] +synonym: "plasma lipoprotein particle receptor activity" NARROW [GOC:BHF] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0030229 +name: very-low-density lipoprotein particle receptor activity +namespace: molecular_function +def: "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732] +synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl] +synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph] +synonym: "VLDL receptor" EXACT [] +xref: Wikipedia:VLDL_receptor +is_a: GO:0030228 ! lipoprotein particle receptor activity + +[Term] +id: GO:0030232 +name: insulin control element activator complex +namespace: cellular_component +def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] +synonym: "ICE activator complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0030233 +name: deoxynucleotide transmembrane transporter activity +namespace: molecular_function +def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0030234 +name: enzyme regulator activity +namespace: molecular_function +alt_id: GO:0010576 +def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] +comment: This term should only be used in cases when the regulator directly interacts with the enzyme. +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +subset: goslim_yeast +synonym: "catalytic regulator activity" EXACT [GOC:dph] +synonym: "enzyme modulator" EXACT [] +synonym: "metalloenzyme regulator activity" NARROW [] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0030235 +name: nitric-oxide synthase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of nitric oxide synthase." [GOC:mah] +comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. +synonym: "nitric oxide synthase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0030237 +name: female sex determination +namespace: biological_process +def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0030238 +name: male sex determination +namespace: biological_process +def: "The specification of male sex of an individual organism." [GOC:mah] +is_a: GO:0007530 ! sex determination +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0030239 +name: myofibril assembly +namespace: biological_process +def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0031032 ! actomyosin structure organization +is_a: GO:0097435 ! supramolecular fiber organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly +relationship: part_of GO:0055002 ! striated muscle cell development + +[Term] +id: GO:0030240 +name: skeletal muscle thin filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] +is_a: GO:0007015 ! actin filament organization +relationship: part_of GO:0014866 ! skeletal myofibril assembly + +[Term] +id: GO:0030241 +name: skeletal muscle myosin thick filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] +is_a: GO:0071688 ! striated muscle myosin thick filament assembly +relationship: part_of GO:0014866 ! skeletal myofibril assembly + +[Term] +id: GO:0030242 +name: autophagy of peroxisome +namespace: biological_process +def: "The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] +synonym: "peroxisome degradation" BROAD [] +synonym: "pexophagy" RELATED [] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0030243 +name: cellulose metabolic process +namespace: biological_process +alt_id: GO:0016177 +def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] +synonym: "cellulose metabolism" EXACT [] +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0030244 +name: cellulose biosynthetic process +namespace: biological_process +alt_id: GO:0016178 +def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] +synonym: "cellulose anabolism" EXACT [] +synonym: "cellulose biosynthesis" EXACT [] +synonym: "cellulose formation" EXACT [] +synonym: "cellulose synthesis" EXACT [] +xref: MetaCyc:PWY-1001 +is_a: GO:0030243 ! cellulose metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0030245 +name: cellulose catabolic process +namespace: biological_process +alt_id: GO:0016179 +def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] +synonym: "cellulose breakdown" EXACT [] +synonym: "cellulose catabolism" EXACT [] +synonym: "cellulose degradation" EXACT [] +is_a: GO:0030243 ! cellulose metabolic process +is_a: GO:0051275 ! beta-glucan catabolic process + +[Term] +id: GO:0030246 +name: carbohydrate binding +namespace: molecular_function +alt_id: GO:0005529 +def: "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [GOC:mah] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_plant +synonym: "selectin" RELATED [] +synonym: "sugar binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0030247 +name: polysaccharide binding +namespace: molecular_function +alt_id: GO:0002506 +def: "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [GOC:mah] +synonym: "polysaccharide assembly with MHC class II protein complex" NARROW [] +is_a: GO:0030246 ! carbohydrate binding + +[Term] +id: GO:0030248 +name: cellulose binding +namespace: molecular_function +def: "Binding to cellulose." [GOC:mah] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0030249 +name: guanylate cyclase regulator activity +namespace: molecular_function +def: "Modulates the activity of guanylate cyclase." [GOC:mah] +is_a: GO:0010851 ! cyclase regulator activity + +[Term] +id: GO:0030250 +name: guanylate cyclase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of guanylate cyclase." [GOC:mah] +synonym: "guanylin" NARROW [] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0010853 ! cyclase activator activity +is_a: GO:0030249 ! guanylate cyclase regulator activity + +[Term] +id: GO:0030251 +name: guanylate cyclase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] +is_a: GO:0010852 ! cyclase inhibitor activity +is_a: GO:0030249 ! guanylate cyclase regulator activity + +[Term] +id: GO:0030252 +name: growth hormone secretion +namespace: biological_process +def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] +synonym: "somatotropin secretion" EXACT [GOC:mah] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0030253 +name: protein secretion by the type I secretion system +namespace: biological_process +def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. +synonym: "protein secretion by the TOSS" EXACT [] +synonym: "protein secretion by the type I protein secretion system" EXACT [] +synonym: "type I protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0030254 +name: protein secretion by the type III secretion system +namespace: biological_process +def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. +synonym: "protein secretion by the T3S" EXACT [] +synonym: "protein secretion by the T3SS" EXACT [] +synonym: "protein secretion by the TTSS" EXACT [] +synonym: "protein secretion by the type III protein secretion system" EXACT [] +synonym: "type III protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0030255 +name: protein secretion by the type IV secretion system +namespace: biological_process +def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. +synonym: "protein secretion by the T4SS" EXACT [] +synonym: "protein secretion by the type IV protein secretion system" EXACT [] +synonym: "type IV protein secretion system" NARROW [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0044097 ! secretion by the type IV secretion system +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0030256 +name: type I protein secretion system complex +namespace: cellular_component +def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] +synonym: "ABC translocator complex" BROAD [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0030257 +name: type III protein secretion system complex +namespace: cellular_component +def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] +synonym: "T3SS complex" EXACT [] +synonym: "TTSS complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0030258 +name: lipid modification +namespace: biological_process +def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0030259 +name: lipid glycosylation +namespace: biological_process +def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] +is_a: GO:0030258 ! lipid modification +is_a: GO:0070085 ! glycosylation + +[Term] +id: GO:0030261 +name: chromosome condensation +namespace: biological_process +alt_id: GO:0000068 +def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] +synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] +synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] +synonym: "nuclear chromosome condensation" EXACT [GOC:bf] +is_a: GO:0006323 ! DNA packaging + +[Term] +id: GO:0030262 +name: apoptotic nuclear changes +namespace: biological_process +def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] +synonym: "apoptotic nuclear change" NARROW [] +is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis + +[Term] +id: GO:0030263 +name: apoptotic chromosome condensation +namespace: biological_process +def: "The compaction of chromatin during apoptosis." [GOC:mah] +synonym: "pyknosis" EXACT [] +xref: Wikipedia:Pyknosis +is_a: GO:0030261 ! chromosome condensation +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0030264 +name: nuclear fragmentation involved in apoptotic nuclear change +namespace: biological_process +def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] +synonym: "apoptotic nuclear fragmentation" EXACT [] +synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] +synonym: "nucleus fragmentation" EXACT [] +is_a: GO:0071763 ! nuclear membrane organization +relationship: part_of GO:0030262 ! apoptotic nuclear changes + +[Term] +id: GO:0030265 +name: phospholipase C-activating rhodopsin mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931] +synonym: "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] +synonym: "PLC-activating rhodopsin mediated signaling pathway" EXACT [GOC:bf] +synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT [] +synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT [] +synonym: "rhodopsin mediated G-protein signaling, coupled to IP3 second messenger" EXACT [GOC:signaling] +synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT [] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0016056 ! rhodopsin mediated signaling pathway + +[Term] +id: GO:0030266 +name: quinate 3-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+." [EC:1.1.1.24] +synonym: "quinate:NAD 3-oxidoreductase activity" EXACT [] +synonym: "quinate:NAD 5-oxidoreductase activity" RELATED [EC:1.1.1.24] +synonym: "quinate:NAD(+) 3-oxidoreductase activity" EXACT [] +synonym: "quinate:NAD(+) 5-oxidoreductase activity" RELATED [EC:1.1.1.24] +synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24] +xref: EC:1.1.1.24 +xref: EC:1.1.1.282 +xref: KEGG_REACTION:R01872 +xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN +xref: RHEA:22364 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030267 +name: glyoxylate reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [RHEA:10992] +synonym: "glycolate:NADP+ oxidoreductase activity" RELATED [] +synonym: "glyoxylate reductase (NADP+)" RELATED [EC:1.1.1.79] +synonym: "NADPH-glyoxylate reductase activity" RELATED [] +xref: EC:1.1.1.79 +xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN +xref: Reactome:R-HSA-389826 "glyoxylate + NADPH + H+ => glycolate + NADP+" +xref: RHEA:10992 +xref: Wikipedia:Glyoxylate_reductase_(NADP+) +is_a: GO:0106345 ! glyoxylate reductase activity + +[Term] +id: GO:0030268 +name: methylenetetrahydromethanopterin dehydrogenase activity +namespace: molecular_function +alt_id: GO:0018536 +def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.98.1, RHEA:16721] +synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.5.98.1] +synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" RELATED [EC:1.5.98.1] +synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.5.98.1] +xref: EC:1.5.98.1 +xref: KEGG_REACTION:R04456 +xref: MetaCyc:1.5.99.9-RXN +xref: RHEA:16721 +xref: UM-BBD_reactionID:r0348 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0030269 +name: tetrahydromethanopterin S-methyltransferase activity +namespace: molecular_function +alt_id: GO:0018709 +def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:53492] +synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" RELATED [EC:2.1.1.86] +synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" RELATED [EC:2.1.1.86] +synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" RELATED [EC:2.1.1.86] +synonym: "tetrahydromethanopterin methyltransferase activity" RELATED [EC:2.1.1.86] +xref: EC:2.1.1.86 +xref: KEGG_REACTION:R04347 +xref: MetaCyc:2.1.1.86-RXN +xref: RHEA:53492 +xref: UM-BBD_reactionID:r0355 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity + +[Term] +id: GO:0030270 +name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity +namespace: molecular_function +alt_id: GO:0018714 +def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18061] +synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" RELATED [EC:2.3.1.101] +synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" RELATED [EC:2.3.1.101] +synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" RELATED [EC:2.3.1.101] +synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" RELATED [EC:2.3.1.101] +synonym: "FTR" RELATED [EC:2.3.1.101] +synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" RELATED [EC:2.3.1.101] +xref: EC:2.3.1.101 +xref: KEGG_REACTION:R03390 +xref: MetaCyc:2.3.1.101-RXN +xref: RHEA:18061 +xref: UM-BBD_reactionID:r0346 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0030271 +name: obsolete chymase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "chymase activity" EXACT [] +synonym: "mast cell protease I activity" NARROW [] +synonym: "mast cell serine proteinase" NARROW [] +synonym: "SK protease activity" RELATED [] +synonym: "skeletal muscle (SK) protease activity" NARROW [] +synonym: "skeletal muscle protease" NARROW [] +synonym: "skin chymotryptic proteinase" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030272 +name: 5-formyltetrahydrofolate cyclo-ligase activity +namespace: molecular_function +alt_id: GO:0019006 +def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10488] +synonym: "5,10-methenyltetrahydrofolate synthetase activity" RELATED [EC:6.3.3.2] +synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" RELATED [EC:6.3.3.2] +synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] +synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" RELATED [EC:6.3.3.2] +synonym: "formyltetrahydrofolic cyclodehydrase activity" RELATED [EC:6.3.3.2] +synonym: "methenyl-THF synthetase activity" RELATED [EC:6.3.3.2] +xref: EC:6.3.3.2 +xref: KEGG_REACTION:R02301 +xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN +xref: Reactome:R-HSA-6801342 "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG" +xref: RHEA:10488 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0030273 +name: melanin-concentrating hormone receptor activity +namespace: molecular_function +def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] +synonym: "MCH receptor" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0030274 +name: LIM domain binding +namespace: molecular_function +def: "Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030275 +name: LRR domain binding +namespace: molecular_function +def: "Binding to a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030276 +name: clathrin binding +namespace: molecular_function +def: "Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030277 +name: maintenance of gastrointestinal epithelium +namespace: biological_process +def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah] +is_a: GO:0010669 ! epithelial structure maintenance +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0030278 +name: regulation of ossification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] +synonym: "regulation of bone biosynthesis" EXACT [] +synonym: "regulation of bone formation" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001503 ! ossification + +[Term] +id: GO:0030279 +name: negative regulation of ossification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] +synonym: "down regulation of ossification" EXACT [] +synonym: "down-regulation of ossification" EXACT [] +synonym: "downregulation of ossification" EXACT [] +synonym: "inhibition of ossification" NARROW [] +synonym: "negative regulation of bone biosynthesis" EXACT [] +synonym: "negative regulation of bone formation" EXACT [] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0001503 ! ossification + +[Term] +id: GO:0030280 +name: structural constituent of skin epidermis +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] +synonym: "structural constituent of epidermis" BROAD [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0030281 +name: structural constituent of cutaneous appendage +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0030282 +name: bone mineralization +namespace: biological_process +def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354] +synonym: "bone calcification" NARROW [] +is_a: GO:0031214 ! biomineral tissue development +relationship: part_of GO:0001503 ! ossification + +[Term] +id: GO:0030283 +name: testosterone dehydrogenase [NAD(P)] activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] +synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] +synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51] +synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51] +synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] +synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51] +synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] +xref: EC:1.1.1.51 +xref: MetaCyc:1.1.1.51-RXN +xref: Reactome:R-HSA-193064 "HSD17B3-like proteins reducde ANDST to TEST" +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030284 +name: estrogen receptor activity +namespace: molecular_function +def: "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392] +comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'. +is_a: GO:0003707 ! steroid hormone receptor activity + +[Term] +id: GO:0030285 +name: integral component of synaptic vesicle membrane +namespace: cellular_component +def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] +subset: goslim_synapse +synonym: "integral to synaptic vesicle membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane + +[Term] +id: GO:0030286 +name: dynein complex +namespace: cellular_component +def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] +is_a: GO:0005875 ! microtubule associated complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0030287 +name: cell wall-bounded periplasmic space +namespace: cellular_component +def: "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu] +synonym: "cell wall bounded periplasmic space" EXACT [] +synonym: "cell wall-enclosed periplasmic space" EXACT [] +synonym: "inner wall zone" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] +synonym: "IWZ" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] +is_a: GO:0042597 ! periplasmic space + +[Term] +id: GO:0030288 +name: outer membrane-bounded periplasmic space +namespace: cellular_component +def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu] +synonym: "outer membrane bounded periplasmic space" EXACT [] +synonym: "outer membrane-enclosed periplasmic space" EXACT [] +xref: Wikipedia:Periplasmic_space +is_a: GO:0042597 ! periplasmic space +relationship: part_of GO:0030313 ! cell envelope + +[Term] +id: GO:0030289 +name: protein phosphatase 4 complex +namespace: cellular_component +def: "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142] +is_a: GO:0005963 ! magnesium-dependent protein serine/threonine phosphatase complex + +[Term] +id: GO:0030290 +name: sphingolipid activator protein activity +namespace: molecular_function +def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732] +synonym: "saposin" NARROW [] +xref: Reactome:R-HSA-1605717 "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage" +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0030291 +name: protein serine/threonine kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity + +[Term] +id: GO:0030292 +name: protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] +is_a: GO:0004860 ! protein kinase inhibitor activity + +[Term] +id: GO:0030293 +name: transmembrane receptor protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] +is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity +is_a: GO:0030547 ! signaling receptor inhibitor activity + +[Term] +id: GO:0030294 +name: receptor signaling protein tyrosine kinase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] +synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] +is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity + +[Term] +id: GO:0030295 +name: protein kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] +is_a: GO:0019209 ! kinase activator activity +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0030296 +name: protein tyrosine kinase activator activity +namespace: molecular_function +def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732] +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0030297 +name: transmembrane receptor protein tyrosine kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] +is_a: GO:0030296 ! protein tyrosine kinase activator activity +is_a: GO:0030546 ! signaling receptor activator activity + +[Term] +id: GO:0030298 +name: receptor signaling protein tyrosine kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] +synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] +is_a: GO:0030296 ! protein tyrosine kinase activator activity + +[Term] +id: GO:0030299 +name: intestinal cholesterol absorption +namespace: biological_process +def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah] +is_a: GO:0030301 ! cholesterol transport +is_a: GO:0098856 ! intestinal lipid absorption +relationship: part_of GO:0044241 ! lipid digestion + +[Term] +id: GO:0030300 +name: regulation of intestinal cholesterol absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417] +is_a: GO:0032374 ! regulation of cholesterol transport +is_a: GO:1904729 ! regulation of intestinal lipid absorption +relationship: regulates GO:0030299 ! intestinal cholesterol absorption + +[Term] +id: GO:0030301 +name: cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732] +is_a: GO:0015918 ! sterol transport + +[Term] +id: GO:0030302 +name: deoxynucleotide transport +namespace: biological_process +def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732] +is_a: GO:0006862 ! nucleotide transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0030303 +name: obsolete stromelysin 2 activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 10 activity" RELATED [] +synonym: "MMP-10" EXACT [] +synonym: "proteoglycanase 2" RELATED [] +synonym: "stromelysin 2 activity" EXACT [] +synonym: "transin 2 activity" RELATED [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030304 +name: obsolete trypsin inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "trypsin inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004867 + +[Term] +id: GO:0030305 +name: heparanase activity +namespace: molecular_function +def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] +synonym: "heparinase activity" RELATED [] +xref: Reactome:R-HSA-1667005 "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)" +xref: Reactome:R-HSA-1678694 "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0030307 +name: positive regulation of cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] +synonym: "activation of cell growth" NARROW [] +synonym: "stimulation of cell growth" NARROW [] +synonym: "up regulation of cell growth" EXACT [] +synonym: "up-regulation of cell growth" EXACT [] +synonym: "upregulation of cell growth" EXACT [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0016049 ! cell growth + +[Term] +id: GO:0030308 +name: negative regulation of cell growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] +synonym: "down regulation of cell growth" EXACT [] +synonym: "down-regulation of cell growth" EXACT [] +synonym: "downregulation of cell growth" EXACT [] +synonym: "inhibition of cell growth" NARROW [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0016049 ! cell growth + +[Term] +id: GO:0030309 +name: poly-N-acetyllactosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +synonym: "poly-N-acetyllactosamine metabolism" EXACT [] +is_a: GO:0006022 ! aminoglycan metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0030310 +name: poly-N-acetyllactosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +synonym: "poly-N-acetyllactosamine breakdown" EXACT [] +synonym: "poly-N-acetyllactosamine catabolism" EXACT [] +synonym: "poly-N-acetyllactosamine degradation" EXACT [] +is_a: GO:0006026 ! aminoglycan catabolic process +is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0030311 +name: poly-N-acetyllactosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] +synonym: "poly-N-acetyllactosamine anabolism" EXACT [] +synonym: "poly-N-acetyllactosamine biosynthesis" EXACT [] +synonym: "poly-N-acetyllactosamine formation" EXACT [] +synonym: "poly-N-acetyllactosamine synthesis" EXACT [] +is_a: GO:0006023 ! aminoglycan biosynthetic process +is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0030312 +name: external encapsulating structure +namespace: cellular_component +def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] +comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0071944 ! cell periphery + +[Term] +id: GO:0030313 +name: cell envelope +namespace: cellular_component +def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] +subset: goslim_pir +xref: Wikipedia:Cell_envelope +is_a: GO:0031975 ! envelope + +[Term] +id: GO:0030314 +name: junctional membrane complex +namespace: cellular_component +def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] +synonym: "triad junction" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0016528 ! sarcoplasm + +[Term] +id: GO:0030315 +name: T-tubule +namespace: cellular_component +def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] +synonym: "transverse tubule" EXACT [] +synonym: "triad" RELATED [] +xref: Wikipedia:T-tubule +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042383 ! sarcolemma + +[Term] +id: GO:0030316 +name: osteoclast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] +synonym: "osteoclast cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030317 +name: flagellated sperm motility +namespace: biological_process +alt_id: GO:0097724 +alt_id: GO:1905419 +def: "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm." [GO_REF:0000060, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:26680031] +synonym: "flagellated sperm movement" EXACT [] +synonym: "sperm flagellum movement" EXACT [GOC:cilia, GOC:krc] +synonym: "sperm flagellum movement involved in flagellated sperm motility" EXACT [] +synonym: "sperm flagellum movement involved in flagellated sperm movement" EXACT [GOC:TermGenie] +synonym: "sperm motility" BROAD [] +synonym: "sperm movement" BROAD [] +xref: Wikipedia:Sperm_motility +is_a: GO:0060285 ! cilium-dependent cell motility +is_a: GO:0060294 ! cilium movement involved in cell motility +is_a: GO:0097722 ! sperm motility + +[Term] +id: GO:0030318 +name: melanocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] +synonym: "melanocyte cell differentiation" EXACT [] +synonym: "melanophore differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0030319 +name: obsolete cellular di-, tri-valent inorganic anion homeostasis +namespace: biological_process +def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] +comment: This term was made obsolete because it has been split. +synonym: "cellular di-, tri-valent inorganic anion homeostasis" EXACT [] +is_obsolete: true +consider: GO:0072501 +consider: GO:0072502 + +[Term] +id: GO:0030320 +name: cellular monovalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:0055083 ! monovalent inorganic anion homeostasis + +[Term] +id: GO:0030321 +name: transepithelial chloride transport +namespace: biological_process +def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah] +is_a: GO:0006821 ! chloride transport +is_a: GO:0070633 ! transepithelial transport + +[Term] +id: GO:0030322 +name: stabilization of membrane potential +namespace: biological_process +def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0030323 +name: respiratory tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] +is_a: GO:0035295 ! tube development +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0030324 +name: lung development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0030323 ! respiratory tube development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0030325 +name: adrenal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] +synonym: "interrenal gland" RELATED [] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0030326 +name: embryonic limb morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172] +is_a: GO:0035108 ! limb morphogenesis +is_a: GO:0035113 ! embryonic appendage morphogenesis + +[Term] +id: GO:0030327 +name: prenylated protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah] +synonym: "prenylated protein breakdown" EXACT [] +synonym: "prenylated protein catabolism" EXACT [] +synonym: "prenylated protein degradation" EXACT [] +is_a: GO:0019941 ! modification-dependent protein catabolic process + +[Term] +id: GO:0030328 +name: prenylcysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] +synonym: "prenylcysteine breakdown" EXACT [] +synonym: "prenylcysteine catabolism" EXACT [] +synonym: "prenylcysteine degradation" EXACT [] +is_a: GO:0030329 ! prenylcysteine metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process + +[Term] +id: GO:0030329 +name: prenylcysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894] +synonym: "prenylcysteine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process + +[Term] +id: GO:0030330 +name: DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +alt_id: GO:0006976 +def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] +synonym: "DNA damage response, activation of p53" RELATED [] +synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk] +synonym: "p53-mediated DNA damage response" BROAD [] +synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk] +is_a: GO:0042770 ! signal transduction in response to DNA damage +is_a: GO:0072331 ! signal transduction by p53 class mediator + +[Term] +id: GO:0030331 +name: estrogen receptor binding +namespace: molecular_function +def: "Binding to an estrogen receptor." [GOC:ai] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0030332 +name: cyclin binding +namespace: molecular_function +def: "Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030334 +name: regulation of cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] +is_a: GO:2000145 ! regulation of cell motility +relationship: regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030335 +name: positive regulation of cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] +synonym: "activation of cell migration" NARROW [] +synonym: "stimulation of cell migration" NARROW [] +synonym: "up regulation of cell migration" EXACT [] +synonym: "up-regulation of cell migration" EXACT [] +synonym: "upregulation of cell migration" EXACT [] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:2000147 ! positive regulation of cell motility +relationship: positively_regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030336 +name: negative regulation of cell migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] +synonym: "down regulation of cell migration" EXACT [] +synonym: "down-regulation of cell migration" EXACT [] +synonym: "downregulation of cell migration" EXACT [] +synonym: "inhibition of cell migration" NARROW [] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:2000146 ! negative regulation of cell motility +relationship: negatively_regulates GO:0016477 ! cell migration + +[Term] +id: GO:0030337 +name: DNA polymerase processivity factor activity +namespace: molecular_function +def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839] +synonym: "processivity clamp" EXACT [] +synonym: "sliding clamp" NARROW [GOC:jh2, PMID:23012374] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0030338 +name: CMP-N-acetylneuraminate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] +comment: Note that this was EC:1.14.13.45. +synonym: "CMP-N-acetylneuraminate hydroxylase activity" RELATED [EC:1.14.18.2] +synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" RELATED [EC:1.14.18.2] +synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] +synonym: "CMP-Neu5Ac hydroxylase activity" RELATED [EC:1.14.18.2] +synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" RELATED [EC:1.14.18.2] +synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" RELATED [EC:1.14.18.2] +synonym: "N-acetylneuraminic monooxygenase activity" RELATED [EC:1.14.18.2] +xref: EC:1.14.18.2 +xref: MetaCyc:1.14.13.45-RXN +xref: RHEA:16145 +is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0030339 +name: fatty-acyl-ethyl-ester synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] +synonym: "FAEE synthase activity" RELATED [EC:3.1.1.67] +synonym: "FAEES activity" RELATED [EC:3.1.1.67] +synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah] +synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" RELATED [EC:3.1.1.67] +xref: EC:3.1.1.67 +xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN +xref: RHEA:16641 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0030340 +name: hyaluronate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] +synonym: "glucuronoglycosaminoglycan lyase activity" RELATED [EC:4.2.2.1] +synonym: "hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] +synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] +synonym: "mucinase activity" RELATED [EC:4.2.2.1] +synonym: "spreading factor activity" RELATED [EC:4.2.2.1] +xref: EC:4.2.2.1 +xref: MetaCyc:HYALURONATE-LYASE-RXN +xref: RHEA:50240 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030341 +name: chondroitin AC lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] +synonym: "ChnAC" RELATED [] +synonym: "chondroitin AC eliminase activity" RELATED [EC:4.2.2.5] +synonym: "chondroitin lyase activity" EXACT [] +synonym: "chondroitin sulfate lyase activity" RELATED [EC:4.2.2.5] +synonym: "chondroitinase AC" RELATED [] +synonym: "chondroitinase activity" BROAD [] +xref: EC:4.2.2.5 +xref: MetaCyc:4.2.2.5-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030342 +name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] +synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296] +synonym: "calcitriol 24-hydroxylase activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-209765 "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it" +xref: Reactome:R-HSA-211950 "CYP24A1 24-hydroxylates CTL" +xref: Reactome:R-HSA-5602004 "Defective CYP24A1 does not 24-hydroxylate CALTOL" +is_a: GO:0070576 ! vitamin D 24-hydroxylase activity + +[Term] +id: GO:0030343 +name: vitamin D3 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309, MetaCyc:RXN-9829] +synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] +xref: MetaCyc:RXN-9829 +xref: Reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D" +xref: Reactome:R-HSA-5602147 "Defective CYP2R1 does not 25-hydroxylate vitamin D" +xref: RHEA:32903 +is_a: GO:0070643 ! vitamin D 25-hydroxylase activity + +[Term] +id: GO:0030345 +name: structural constituent of tooth enamel +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] +is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance + +[Term] +id: GO:0030346 +name: protein phosphatase 2B binding +namespace: molecular_function +def: "Binding to a protein phosphatase 2B." [GOC:jl] +synonym: "calcineurin binding" EXACT [] +synonym: "protein phosphatase 3 binding" RELATED [GOC:dph, GOC:rl] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0030348 +name: syntaxin-3 binding +namespace: molecular_function +def: "Binding to a syntaxin-3 SNAP receptor." [GOC:ai] +is_a: GO:0019905 ! syntaxin binding + +[Term] +id: GO:0030350 +name: iron-responsive element binding +namespace: molecular_function +def: "Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] +synonym: "IRE binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0030351 +name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen" +is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity + +[Term] +id: GO:0030352 +name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:0030353 +name: fibroblast growth factor receptor antagonist activity +namespace: molecular_function +def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] +synonym: "FGF receptor antagonist activity" EXACT [] +synonym: "FGFR antagonist activity" EXACT [] +is_a: GO:0005104 ! fibroblast growth factor receptor binding +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0030354 +name: melanin-concentrating hormone activity +namespace: molecular_function +def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0030355 +name: obsolete small nucleolar ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "small nucleolar ribonucleoprotein" EXACT [] +synonym: "snoRNP" EXACT [] +is_obsolete: true +replaced_by: GO:0005732 + +[Term] +id: GO:0030356 +name: obsolete small cytoplasmic ribonucleoprotein +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it describes a cellular component rather than a molecular function. +synonym: "scRNP" EXACT [] +synonym: "small cytoplasmic ribonucleoprotein" EXACT [] +is_obsolete: true +replaced_by: GO:1990904 + +[Term] +id: GO:0030363 +name: obsolete pre-mRNA cleavage factor activity +namespace: molecular_function +def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856] +comment: This term was made obsolete because it describes a biological process. +synonym: "pre-mRNA cleavage factor activity" EXACT [] +is_obsolete: true +consider: GO:0006379 + +[Term] +id: GO:0030364 +name: obsolete cleavage and polyadenylylation specificity factor activity +namespace: molecular_function +def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856] +comment: This term was made obsolete because it describes a cellular component. +synonym: "cleavage and polyadenylation specificity factor activity" EXACT [] +synonym: "cleavage and polyadenylylation specificity factor activity" EXACT [] +synonym: "cleavage/polyadenylation specificity factor activity" EXACT [] +synonym: "CPSF" EXACT [] +is_obsolete: true +replaced_by: GO:0005847 +consider: GO:0006378 +consider: GO:0006379 + +[Term] +id: GO:0030365 +name: obsolete cleavage stimulation factor activity +namespace: molecular_function +def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856] +comment: This term was made obsolete because it describes a cellular component. +synonym: "cleavage stimulation factor activity" EXACT [] +synonym: "CstF" EXACT [] +is_obsolete: true +replaced_by: GO:0005848 +consider: GO:0006379 + +[Term] +id: GO:0030366 +name: molybdopterin synthase activity +namespace: molecular_function +def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] +xref: EC:2.8.1.12 +xref: Reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z" +xref: RHEA:26333 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0030367 +name: interleukin-17 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-17 receptor." [GOC:ai] +synonym: "IL-17" NARROW [] +synonym: "interleukin-17 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0030368 +name: interleukin-17 receptor activity +namespace: molecular_function +def: "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling] +synonym: "IL-17 receptor activity" EXACT [GOC:mah] +synonym: "IL-17R" EXACT [] +xref: Wikipedia:Interleukin-17_receptor +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0030369 +name: ICAM-3 receptor activity +namespace: molecular_function +def: "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813] +comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0030370 +name: intercellular adhesion molecule-3 receptor binding +namespace: molecular_function +def: "Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] +synonym: "ICAM-3 receptor binding" EXACT [] +synonym: "ICAM-3 receptor ligand" NARROW [] +synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0030371 +name: translation repressor activity +namespace: molecular_function +def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0030372 +name: high molecular weight B cell growth factor receptor binding +namespace: molecular_function +def: "Binding to a high molecular weight B cell growth factor receptor." [GOC:ai] +synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] +synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] +synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] +synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] +is_a: GO:0070851 ! growth factor receptor binding + +[Term] +id: GO:0030373 +name: high molecular weight B cell growth factor receptor activity +namespace: molecular_function +def: "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271] +synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] +synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] +synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] +synonym: "HMW-BCGF receptor" EXACT [PMID:2681271] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0030374 +name: nuclear receptor coactivator activity +namespace: molecular_function +alt_id: GO:0038049 +def: "A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:dph, GOC:tb] +comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. +synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT [] +synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] +synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] +synonym: "nuclear receptor transcription coactivator activity" EXACT [] +synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT [] +is_a: GO:0003713 ! transcription coactivator activity + +[Term] +id: GO:0030375 +name: obsolete thyroid hormone receptor coactivator activity +namespace: molecular_function +alt_id: GO:0010861 +def: "OBSOLETE. The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it represented a gene product. +synonym: "thyroid hormone receptor activator activity" NARROW [] +synonym: "thyroid hormone receptor co-activator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030377 +name: urokinase plasminogen activator receptor activity +namespace: molecular_function +def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079] +synonym: "U-plasminogen activator receptor activity" EXACT [GOC:bf] +synonym: "uPAR" EXACT [] +synonym: "urokinase plasminogen activator receptor" EXACT [] +xref: Wikipedia:Urokinase_receptor +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0030378 +name: serine racemase activity +namespace: molecular_function +def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] +xref: EC:5.1.1.18 +xref: MetaCyc:5.1.1.18-RXN +xref: Reactome:R-HSA-9014766 "PXLP-K56-SRR dimer isomerises L-Ser to D-Ser" +xref: RHEA:10980 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0030379 +name: neurotensin receptor activity, non-G protein-coupled +namespace: molecular_function +def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851] +synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] +synonym: "neurotensin receptor activity, non-G-protein coupled" EXACT [] +synonym: "non G protein coupled neurotensin receptor activity" EXACT [] +synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] +synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0030380 +name: interleukin-17E receptor binding +namespace: molecular_function +def: "Binding to an interleukin-17E receptor." [GOC:ai] +synonym: "IL-17E" NARROW [] +synonym: "interleukin-17E receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0030381 +name: chorion-containing eggshell pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0003002 ! regionalization +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0007304 ! chorion-containing eggshell formation + +[Term] +id: GO:0030382 +name: sperm mitochondrion organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] +synonym: "sperm mitochondria organisation" EXACT [] +synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah] +synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0030383 +name: obsolete host-pathogen interaction +namespace: biological_process +def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "host-pathogen interaction" EXACT [] +is_obsolete: true +consider: GO:0044403 + +[Term] +id: GO:0030386 +name: ferredoxin-thioredoxin reductase complex +namespace: cellular_component +def: "A protein complex that possesses ferredoxin-thioredoxin reductase activity." [GOC:mah] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin-thioredoxin reductase activity ; GO:0103012'. +synonym: "ferredoxin:thioredoxin reductase complex" EXACT [] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0030388 +name: fructose 1,6-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732] +synonym: "fructose 1,6-bisphosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0030389 +name: fructosamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +synonym: "fructosamine metabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:0030391 +name: fructosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +synonym: "fructosamine anabolism" EXACT [] +synonym: "fructosamine biosynthesis" EXACT [] +synonym: "fructosamine formation" EXACT [] +synonym: "fructosamine synthesis" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0030392 +name: fructosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] +synonym: "fructosamine breakdown" EXACT [] +synonym: "fructosamine catabolism" EXACT [] +synonym: "fructosamine degradation" EXACT [] +is_a: GO:0030389 ! fructosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0030393 +name: fructoselysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai] +synonym: "fructoselysine metabolism" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0030389 ! fructosamine metabolic process + +[Term] +id: GO:0030394 +name: fructoseglycine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai] +synonym: "fructoseglycine metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0030389 ! fructosamine metabolic process + +[Term] +id: GO:0030395 +name: lactose binding +namespace: molecular_function +def: "Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:0192800981] +is_a: GO:0048030 ! disaccharide binding + +[Term] +id: GO:0030397 +name: membrane disassembly +namespace: biological_process +def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] +synonym: "membrane breakdown" EXACT [] +synonym: "membrane catabolism" EXACT [] +synonym: "membrane degradation" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0030398 +name: peroxisomal membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760] +synonym: "peroxisomal membrane breakdown" EXACT [] +synonym: "peroxisomal membrane catabolism" EXACT [] +synonym: "peroxisomal membrane degradation" EXACT [] +is_a: GO:0030397 ! membrane disassembly +is_a: GO:1903008 ! organelle disassembly +relationship: part_of GO:0030242 ! autophagy of peroxisome + +[Term] +id: GO:0030399 +name: autophagosome membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah] +synonym: "autophagic membrane breakdown" EXACT [] +synonym: "autophagic membrane catabolism" NARROW [GOC:autophagy] +synonym: "autophagic membrane degradation" NARROW [GOC:autophagy] +synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy] +is_a: GO:0030397 ! membrane disassembly +is_a: GO:1905037 ! autophagosome organization + +[Term] +id: GO:0030400 +name: obsolete protease substrate recruitment factor activity +namespace: molecular_function +def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370] +comment: This term was made obsolete because it represents a gene product. +synonym: "protease substrate recruitment factor activity" EXACT [] +is_obsolete: true +consider: GO:0030674 + +[Term] +id: GO:0030401 +name: obsolete transcription antiterminator activity +namespace: molecular_function +def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "transcription antiterminator activity" EXACT [] +synonym: "transcriptional antiterminator activity" EXACT [] +is_obsolete: true +consider: GO:0001072 +consider: GO:0001073 +consider: GO:0006353 + +[Term] +id: GO:0030402 +name: obsolete matrilysin-2 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrilysin-2 activity" EXACT [] +synonym: "matrix metalloproteinase 26" EXACT [] +synonym: "MMP-26" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030403 +name: obsolete collagenase 4 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "collagenase 4 activity" EXACT [] +synonym: "matrix metalloproteinase 18" EXACT [] +synonym: "MMP-18" NARROW [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030404 +name: obsolete collagenase 3 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "collagenase 3 activity" EXACT [] +synonym: "matrix metalloproteinase 13" EXACT [] +synonym: "MMP-13" EXACT [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0030405 +name: obsolete matrix metalloproteinase 19 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 19 activity" EXACT [] +synonym: "MMP-19" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030406 +name: obsolete matrix metalloproteinase 25 activity +namespace: molecular_function +def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "matrix metalloproteinase 25 activity" EXACT [] +synonym: "MMP-25" EXACT [] +synonym: "MT6-MMP" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0030408 +name: glycine formimidoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [RHEA:24288] +synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" RELATED [EC:2.1.2.4] +synonym: "FIG formiminotransferase activity" RELATED [EC:2.1.2.4] +synonym: "formimidoyltransferase activity" BROAD [] +synonym: "formiminoglycine formiminotransferase activity" RELATED [EC:2.1.2.4] +synonym: "formiminotransferase activity" BROAD [] +synonym: "glycine formiminotransferase activity" EXACT [] +xref: EC:2.1.2.4 +xref: KEGG_REACTION:R02729 +xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN +xref: RHEA:24288 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0030409 +name: glutamate formimidoyltransferase activity +namespace: molecular_function +alt_id: GO:0030407 +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [RHEA:15097] +synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" RELATED [EC:2.1.2.5] +synonym: "formimidoyltransferase activity" BROAD [] +synonym: "formiminoglutamic acid transferase activity" RELATED [EC:2.1.2.5] +synonym: "formiminoglutamic formiminotransferase activity" RELATED [EC:2.1.2.5] +synonym: "formiminotransferase activity" BROAD [] +synonym: "glutamate formiminotransferase activity" EXACT [] +synonym: "glutamate formyltransferase activity" RELATED [EC:2.1.2.5] +xref: EC:2.1.2.5 +xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN +xref: RHEA:15097 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0030410 +name: nicotianamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16481] +synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.43] +xref: EC:2.5.1.43 +xref: KEGG_REACTION:R00075 +xref: MetaCyc:2.5.1.43-RXN +xref: RHEA:16481 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0030411 +name: scytalone dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24396] +synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" RELATED [EC:4.2.1.94] +synonym: "scytalone 7,8-hydro-lyase activity" RELATED [EC:4.2.1.94] +xref: EC:4.2.1.94 +xref: KEGG_REACTION:R02907 +xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN +xref: RHEA:24396 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0030412 +name: formimidoyltetrahydrofolate cyclodeaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22736] +comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. +synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" RELATED [EC:4.3.1.4] +synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" RELATED [EC:4.3.1.4] +synonym: "formiminotetrahydrofolate cyclodeaminase activity" RELATED [EC:4.3.1.4] +xref: EC:4.3.1.4 +xref: KEGG_REACTION:R02302 +xref: MetaCyc:4.3.1.4-RXN +xref: Reactome:R-HSA-70920 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate" +xref: RHEA:22736 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0030413 +name: competence pheromone activity +namespace: molecular_function +def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] +is_a: GO:0005186 ! pheromone activity + +[Term] +id: GO:0030414 +name: peptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] +synonym: "protease inhibitor activity" NARROW [GOC:mah] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0061134 ! peptidase regulator activity + +[Term] +id: GO:0030415 +name: obsolete carboxypeptidase A inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "carboxypeptidase A inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0030414 + +[Term] +id: GO:0030416 +name: methylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylamine (CH3NH2)." [ISBN:0721662544] +synonym: "methylamine metabolism" EXACT [] +synonym: "methylammonium metabolic process" EXACT [] +synonym: "methylammonium metabolism" EXACT [] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0030417 +name: nicotianamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +synonym: "nicotianamine metabolism" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0030418 +name: nicotianamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +synonym: "nicotianamine anabolism" EXACT [] +synonym: "nicotianamine biosynthesis" EXACT [] +synonym: "nicotianamine formation" EXACT [] +synonym: "nicotianamine synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0030417 ! nicotianamine metabolic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0030419 +name: nicotianamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] +synonym: "nicotianamine breakdown" EXACT [] +synonym: "nicotianamine catabolism" EXACT [] +synonym: "nicotianamine degradation" EXACT [] +is_a: GO:0030417 ! nicotianamine metabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072352 ! tricarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0030420 +name: establishment of competence for transformation +namespace: biological_process +def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027] +is_a: GO:0031668 ! cellular response to extracellular stimulus +relationship: part_of GO:0009294 ! DNA mediated transformation + +[Term] +id: GO:0030421 +name: defecation +namespace: biological_process +def: "The expulsion of feces from the rectum." [GOC:mah] +xref: Wikipedia:Defecation +is_a: GO:0007588 ! excretion +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0030422 +name: production of siRNA involved in RNA interference +namespace: biological_process +def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] +synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah] +synonym: "RNA interference, production of guide RNAs" EXACT [] +synonym: "RNA interference, production of siRNA" EXACT [GOC:mah] +is_a: GO:0070918 ! primary sncRNA processing +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0030423 +name: targeting of mRNA for destruction involved in RNA interference +namespace: biological_process +def: "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] +synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0030424 +name: axon +namespace: cellular_component +def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] +xref: NIF_Subcellular:sao1770195789 +xref: Wikipedia:Axon +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0030425 +name: dendrite +namespace: cellular_component +def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] +xref: NIF_Subcellular:sao1211023249 +xref: Wikipedia:Dendrite +is_a: GO:0043005 ! neuron projection +relationship: part_of GO:0097447 ! dendritic tree + +[Term] +id: GO:0030426 +name: growth cone +namespace: cellular_component +def: "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] +xref: Wikipedia:Growth_cone +is_a: GO:0030427 ! site of polarized growth +relationship: part_of GO:0150034 ! distal axon + +[Term] +id: GO:0030427 +name: site of polarized growth +namespace: cellular_component +alt_id: GO:0000134 +alt_id: GO:0030483 +def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0030428 +name: cell septum +namespace: cellular_component +def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] +subset: goslim_pir +synonym: "cross wall" EXACT [] +synonym: "septum" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0030429 +name: kynureninase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] +synonym: "kynurenine hydrolase activity" RELATED [EC:3.7.1.3] +synonym: "L-kynurenine hydrolase activity" RELATED [EC:3.7.1.3] +xref: EC:3.7.1.3 +xref: MetaCyc:KYNURENINASE-RXN +xref: Reactome:R-HSA-71217 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine" +xref: RHEA:16813 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0030430 +name: host cell cytoplasm +namespace: cellular_component +alt_id: GO:0097679 +def: "The cytoplasm of a host cell." [GOC:mah] +synonym: "other organism cytoplasm" RELATED [] +is_a: GO:0033646 ! host intracellular part + +[Term] +id: GO:0030431 +name: sleep +namespace: biological_process +def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] +subset: goslim_pir +synonym: "diapause" RELATED [] +synonym: "dormancy" RELATED [] +synonym: "lethargus" RELATED [] +xref: Wikipedia:Sleep +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030432 +name: peristalsis +namespace: biological_process +def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732] +xref: Wikipedia:Peristalsis +is_a: GO:0014821 ! phasic smooth muscle contraction + +[Term] +id: GO:0030433 +name: ubiquitin-dependent ERAD pathway +namespace: biological_process +def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] +comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. +synonym: "endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "endoplasmic reticulum-associated ubiqutin-dependent protein catabolism" EXACT [] +synonym: "ER-associated ubiquitin-dependent protein breakdown" EXACT [] +synonym: "ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] +synonym: "ER-associated ubiquitin-dependent protein catabolism" EXACT [] +synonym: "ER-associated ubiquitin-dependent protein degradation" EXACT [] +synonym: "ERAD" BROAD [] +synonym: "ubiquitin-dependent proteasomal protein catabolism of ER proteins" EXACT [GOC:bf] +is_a: GO:0036503 ! ERAD pathway +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0030435 +name: sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] +comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. +synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] +synonym: "spore biosynthesis" EXACT [] +synonym: "spore differentiation" EXACT [] +synonym: "spore formation" EXACT [] +xref: Wikipedia:Sporogenesis +is_a: GO:0030154 ! cell differentiation +is_a: GO:0043934 ! sporulation +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0030436 +name: asexual sporulation +namespace: biological_process +def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886] +subset: goslim_aspergillus +synonym: "asexual reproductive sporulation" EXACT [] +synonym: "asexual spore formation" EXACT [] +synonym: "mitotic spore formation" EXACT [] +synonym: "mitotic sporulation" EXACT [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0043934 ! sporulation + +[Term] +id: GO:0030437 +name: ascospore formation +namespace: biological_process +alt_id: GO:0007151 +def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736] +comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. +subset: goslim_pombe +synonym: "ascospore biosynthesis" EXACT [] +synonym: "spore formation" BROAD [] +synonym: "sporulation" BROAD [] +is_a: GO:0022413 ! reproductive process in single-celled organism +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0030438 +name: obsolete MAPKKK cascade during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "MAPKKK cascade during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030439 +name: obsolete activation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPK during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030440 +name: obsolete activation of MAPKK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKK during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030441 +name: obsolete activation of MAPKKK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKKK during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030442 +name: obsolete inactivation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "inactivation of MAPK during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030443 +name: obsolete nuclear translocation of MAPK during sporulation (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mcc] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "nuclear translocation of MAPK during sporulation (sensu Fungi)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030444 +name: obsolete microtubule depolymerization during nuclear congression +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because the entire branch of the ontology was changed. +synonym: "microtubule depolymerization during nuclear congression" EXACT [] +is_obsolete: true +replaced_by: GO:0007019 + +[Term] +id: GO:0030445 +name: yeast-form cell wall +namespace: cellular_component +def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] +comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. +is_a: GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0030446 +name: hyphal cell wall +namespace: cellular_component +def: "The cell wall surrounding a fungal hypha." [GOC:mah] +comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. +is_a: GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0030447 +name: filamentous growth +namespace: biological_process +def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] +subset: goslim_aspergillus +subset: goslim_candida +is_a: GO:0040007 ! growth + +[Term] +id: GO:0030448 +name: hyphal growth +namespace: biological_process +alt_id: GO:0075061 +def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] +subset: goslim_candida +synonym: "formation of symbiont invasive hypha in host" EXACT [] +synonym: "formation of symbiont invasive hypha within host" EXACT [] +synonym: "formation of symbiont invasive hypha within host during symbiotic interaction" EXACT [] +synonym: "invasive hyphal growth" EXACT [] +synonym: "symbiont invasive hypha formation within host" EXACT [] +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0030449 +name: regulation of complement activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators] +synonym: "regulation of complement cascade" EXACT [GOC:add] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0002920 ! regulation of humoral immune response +relationship: regulates GO:0006956 ! complement activation + +[Term] +id: GO:0030450 +name: regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators] +synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add] +is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin +is_a: GO:0030449 ! regulation of complement activation +relationship: regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0030451 +name: regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators] +synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add] +is_a: GO:0030449 ! regulation of complement activation +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0030455 +name: obsolete MAPKKK cascade (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "MAPKKK cascade (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030456 +name: obsolete activation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPK (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030457 +name: obsolete activation of MAPKK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKK (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030458 +name: obsolete activation of MAPKKK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "activation of MAPKKK (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030459 +name: obsolete inactivation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "inactivation of MAPK (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030460 +name: obsolete nuclear translocation of MAPK (mating sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:elh] +comment: This term was made obsolete because it is a gene product specific term. +synonym: "nuclear translocation of MAPK (mating sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0000750 + +[Term] +id: GO:0030463 +name: obsolete cell aging (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. +synonym: "cell aging (sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0007569 + +[Term] +id: GO:0030464 +name: obsolete aging dependent sterility (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:sgd_curators] +comment: This term was made obsolete because it reflected a trait or phenotype. +synonym: "aging dependent sterility (sensu Fungi)" EXACT [] +is_obsolete: true +consider: GO:0030466 + +[Term] +id: GO:0030465 +name: obsolete autophagic death (sensu Fungi) +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because a more correct term has been created. +synonym: "autophagic death (sensu Fungi)" EXACT [] +is_obsolete: true +consider: GO:0048102 + +[Term] +id: GO:0030466 +name: silent mating-type cassette heterochromatin assembly +namespace: biological_process +alt_id: GO:0006347 +alt_id: GO:0035389 +def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc] +synonym: "aging-dependent sterility" NARROW [] +synonym: "chromatin silencing at HML and HMR" NARROW [] +synonym: "chromatin silencing at silent mating-type cassette" EXACT [] +synonym: "establishment of chromatin silencing at silent mating-type cassette" RELATED [] +synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] +synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah] +is_a: GO:0140719 ! constitutive heterochromatin assembly + +[Term] +id: GO:0030470 +name: obsolete spore germination (sensu Fungi) +namespace: biological_process +alt_id: GO:0007153 +def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc] +comment: This term was made obsolete because a sensu term was not needed. +synonym: "germination (sensu Saccharomyces)" NARROW [] +synonym: "spore germination (sensu Fungi)" EXACT [] +is_obsolete: true +replaced_by: GO:0009847 + +[Term] +id: GO:0030471 +name: obsolete spindle pole body and microtubule cycle (sensu Fungi) +namespace: biological_process +alt_id: GO:0007102 +def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649] +comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. +synonym: "spindle pole body and microtubule cycle (sensu Fungi)" EXACT [] +synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW [] +is_obsolete: true +consider: GO:0007051 +consider: GO:0051300 + +[Term] +id: GO:0030473 +name: nuclear migration along microtubule +namespace: biological_process +alt_id: GO:0000065 +def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] +synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] +synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] +synonym: "microtubule-dependent nuclear positioning" EXACT [] +synonym: "microtubule-dependent nucleus positioning" EXACT [] +synonym: "microtubule-mediated nuclear migration" EXACT [] +synonym: "nuclear migration, microtubule-mediated" EXACT [] +synonym: "nuclear movement, microtubule-mediated" BROAD [] +synonym: "nucleus migration" BROAD [] +synonym: "transport of nucleus by microtubules" EXACT [] +synonym: "transport of nucleus, microtubule-mediated" EXACT [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0030474 +name: spindle pole body duplication +namespace: biological_process +alt_id: GO:0007103 +alt_id: GO:0031046 +def: "Construction of a new spindle pole body." [GOC:clt] +synonym: "spindle pole body assembly" EXACT [] +synonym: "spindle pole body biogenesis" EXACT [] +synonym: "spindle pole body biosynthesis" EXACT [] +synonym: "spindle pole body duplication associated with nuclear envelope" EXACT [] +synonym: "spindle pole body duplication in cytoplasm" EXACT [] +synonym: "spindle pole body formation" EXACT [] +synonym: "spindle pole body replication" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0051300 ! spindle pole body organization + +[Term] +id: GO:0030476 +name: ascospore wall assembly +namespace: biological_process +alt_id: GO:0007152 +def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385] +synonym: "spore wall assembly" BROAD [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0042244 ! spore wall assembly +is_a: GO:0071940 ! fungal-type cell wall assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0070591 ! ascospore wall biogenesis + +[Term] +id: GO:0030478 +name: actin cap +namespace: cellular_component +alt_id: GO:0000143 +def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, PMID:21494665] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0030479 +name: actin cortical patch +namespace: cellular_component +alt_id: GO:0005857 +def: "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] +synonym: "actin patch" EXACT [] +is_a: GO:0061645 ! endocytic patch +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0030484 +name: obsolete muscle fiber +namespace: cellular_component +def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194] +comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'. +synonym: "muscle fiber" EXACT [] +synonym: "muscle fibre" EXACT [] +is_obsolete: true +consider: GO:0043292 + +[Term] +id: GO:0030485 +name: smooth muscle contractile fiber +namespace: cellular_component +def: "The contractile fiber of smooth muscle cells." [GOC:mah] +is_a: GO:0043292 ! contractile fiber + +[Term] +id: GO:0030486 +name: smooth muscle dense body +namespace: cellular_component +def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030485 ! smooth muscle contractile fiber + +[Term] +id: GO:0030487 +name: inositol-4,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah] +is_a: GO:0016312 ! inositol bisphosphate phosphatase activity + +[Term] +id: GO:0030488 +name: tRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0030489 +name: obsolete processing of 27S pre-rRNA +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:curators] +comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product. +synonym: "processing of 27S pre-rRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030490 +name: maturation of SSU-rRNA +namespace: biological_process +def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] +synonym: "processing of 20S pre-rRNA" NARROW [] +synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006364 ! rRNA processing +relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis + +[Term] +id: GO:0030491 +name: heteroduplex formation +namespace: biological_process +def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0030492 +name: hemoglobin binding +namespace: molecular_function +def: "Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl] +synonym: "globin binding" BROAD [] +synonym: "haemoglobin binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030493 +name: bacteriochlorophyll metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] +synonym: "bacteriochlorophyll metabolism" EXACT [] +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0030494 +name: bacteriochlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] +synonym: "bacteriochlorophyll anabolism" EXACT [] +synonym: "bacteriochlorophyll biosynthesis" EXACT [] +synonym: "bacteriochlorophyll formation" EXACT [] +synonym: "bacteriochlorophyll synthesis" EXACT [] +is_a: GO:0015995 ! chlorophyll biosynthetic process +is_a: GO:0030493 ! bacteriochlorophyll metabolic process + +[Term] +id: GO:0030495 +name: bacteriochlorophyll catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators] +synonym: "bacteriochlorophyll breakdown" EXACT [] +synonym: "bacteriochlorophyll catabolism" EXACT [] +synonym: "bacteriochlorophyll degradation" EXACT [] +is_a: GO:0015996 ! chlorophyll catabolic process +is_a: GO:0030493 ! bacteriochlorophyll metabolic process + +[Term] +id: GO:0030496 +name: midbody +namespace: cellular_component +def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] +subset: goslim_pir +xref: Wikipedia:Midbody_(cell_biology) +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0030497 +name: fatty acid elongation +namespace: biological_process +def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0030500 +name: regulation of bone mineralization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0070167 ! regulation of biomineral tissue development +relationship: regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030501 +name: positive regulation of bone mineralization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] +synonym: "activation of bone mineralization" NARROW [] +synonym: "stimulation of bone mineralization" NARROW [] +synonym: "up regulation of bone mineralization" EXACT [] +synonym: "up-regulation of bone mineralization" EXACT [] +synonym: "upregulation of bone mineralization" EXACT [] +is_a: GO:0030500 ! regulation of bone mineralization +is_a: GO:0045778 ! positive regulation of ossification +is_a: GO:0070169 ! positive regulation of biomineral tissue development +relationship: positively_regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030502 +name: negative regulation of bone mineralization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] +synonym: "down regulation of bone mineralization" EXACT [] +synonym: "down-regulation of bone mineralization" EXACT [] +synonym: "downregulation of bone mineralization" EXACT [] +synonym: "inhibition of bone mineralization" NARROW [] +is_a: GO:0030279 ! negative regulation of ossification +is_a: GO:0030500 ! regulation of bone mineralization +is_a: GO:0070168 ! negative regulation of biomineral tissue development +relationship: negatively_regulates GO:0030282 ! bone mineralization + +[Term] +id: GO:0030504 +name: inorganic diphosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of inorganic diphosphate across a membrane." [PMID:11326272] +synonym: "inorganic pyrophosphate transporter activity" EXACT [] +xref: Reactome:R-HSA-5226964 "ANKH transports PPi from cytosol to extracellular region" +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:0030505 +name: inorganic diphosphate transport +namespace: biological_process +def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "inorganic pyrophosphate transport" EXACT [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0030506 +name: ankyrin binding +namespace: molecular_function +def: "Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0030507 +name: spectrin binding +namespace: molecular_function +def: "Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] +is_a: GO:0008092 ! cytoskeletal protein binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0030508 +name: obsolete thiol-disulfide exchange intermediate activity +namespace: molecular_function +def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] +comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process. +synonym: "glutaredoxin" NARROW [] +synonym: "thiol-disulfide exchange intermediate activity" EXACT [] +synonym: "thiol-disulphide exchange intermediate activity" EXACT [] +synonym: "thioredoxin" NARROW [] +is_obsolete: true +consider: GO:0003756 +consider: GO:0015036 + +[Term] +id: GO:0030509 +name: BMP signaling pathway +namespace: biological_process +alt_id: GO:0008101 +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PMID:17428827] +synonym: "BMP receptor signaling pathway" RELATED [] +synonym: "BMP signalling pathway" EXACT [] +synonym: "bone morphogenetic protein signaling pathway" EXACT [] +synonym: "bone morphogenetic protein signalling pathway" EXACT [] +synonym: "decapentaplegic receptor signaling pathway" NARROW [GOC:bf, GOC:sart, GOC:signaling] +synonym: "decapentaplegic receptor signalling pathway" NARROW [] +synonym: "decapentaplegic signaling pathway" NARROW [] +synonym: "dpp receptor signaling pathway" NARROW [] +synonym: "dpp receptor signalling pathway" NARROW [] +synonym: "dpp signaling pathway" NARROW [GOC:bf] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: part_of GO:0071773 ! cellular response to BMP stimulus + +[Term] +id: GO:0030510 +name: regulation of BMP signaling pathway +namespace: biological_process +alt_id: GO:0090097 +def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] +synonym: "regulation of BMP receptor signaling pathway" RELATED [] +synonym: "regulation of BMP signalling pathway" EXACT [] +synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] +synonym: "regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] +synonym: "regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] +synonym: "regulation of decapentaplegic signaling pathway" NARROW [] +is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030511 +name: positive regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT [] +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:1903846 ! positive regulation of cellular response to transforming growth factor beta stimulus +relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0030512 +name: negative regulation of transforming growth factor beta receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] +synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT [] +synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW [] +synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT [] +synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT [] +synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT [] +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway + +[Term] +id: GO:0030513 +name: positive regulation of BMP signaling pathway +namespace: biological_process +alt_id: GO:0090098 +def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] +synonym: "activation of BMP signaling pathway" NARROW [] +synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] +synonym: "positive regulation of BMP signalling pathway" EXACT [] +synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] +synonym: "positive regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] +synonym: "positive regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] +synonym: "positive regulation of decapentaplegic signaling pathway" NARROW [] +synonym: "stimulation of BMP signaling pathway" NARROW [] +synonym: "up regulation of BMP signaling pathway" EXACT [] +synonym: "up-regulation of BMP signaling pathway" EXACT [] +synonym: "upregulation of BMP signaling pathway" EXACT [] +is_a: GO:0030510 ! regulation of BMP signaling pathway +is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: positively_regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030514 +name: negative regulation of BMP signaling pathway +namespace: biological_process +alt_id: GO:0090099 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] +synonym: "down regulation of BMP signaling pathway" EXACT [] +synonym: "down-regulation of BMP signaling pathway" EXACT [] +synonym: "downregulation of BMP signaling pathway" EXACT [] +synonym: "inhibition of BMP signaling pathway" NARROW [] +synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] +synonym: "negative regulation of BMP signalling pathway" EXACT [] +synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] +synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] +synonym: "negative regulation of decapentaplegic receptor signaling pathway" NARROW [GOC:bf] +synonym: "negative regulation of decapentaplegic receptor signalling pathway" NARROW [GOC:mah] +synonym: "negative regulation of decapentaplegic signaling pathway" NARROW [] +is_a: GO:0030510 ! regulation of BMP signaling pathway +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +relationship: negatively_regulates GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0030515 +name: snoRNA binding +namespace: molecular_function +def: "Binding to a small nucleolar RNA." [GOC:mah] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0030516 +name: regulation of axon extension +namespace: biological_process +def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0061387 ! regulation of extent of cell growth +relationship: regulates GO:0048675 ! axon extension + +[Term] +id: GO:0030517 +name: negative regulation of axon extension +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] +synonym: "down regulation of axon extension" EXACT [] +synonym: "down-regulation of axon extension" EXACT [] +synonym: "downregulation of axon extension" EXACT [] +synonym: "inhibition of axon extension" NARROW [] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0050771 ! negative regulation of axonogenesis +relationship: negatively_regulates GO:0048675 ! axon extension + +[Term] +id: GO:0030518 +name: intracellular steroid hormone receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling] +synonym: "steroid hormone receptor signaling pathway" BROAD [GOC:bf] +synonym: "steroid hormone receptor signalling pathway" BROAD [GOC:bf] +is_a: GO:0030522 ! intracellular receptor signaling pathway +is_a: GO:0043401 ! steroid hormone mediated signaling pathway + +[Term] +id: GO:0030519 +name: snoRNP binding +namespace: molecular_function +def: "Binding to a small nucleolar ribonucleoprotein particle." [GOC:mah] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0030520 +name: intracellular estrogen receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)." [GOC:mah, GOC:signaling] +synonym: "estrogen receptor signaling pathway" BROAD [GOC:bf] +synonym: "estrogen receptor signalling pathway" BROAD [GOC:bf] +is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0030521 +name: androgen receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] +synonym: "androgen receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0030522 +name: intracellular receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] +synonym: "intracellular receptor mediated signaling pathway" EXACT [] +synonym: "intracellular receptor-mediated signaling pathway" EXACT [] +synonym: "intracellular receptor-mediated signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0030523 +name: dihydrolipoamide S-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] +xref: EC:2.3.1.12 +is_a: GO:0016417 ! S-acyltransferase activity + +[Term] +id: GO:0030526 +name: granulocyte macrophage colony-stimulating factor receptor complex +namespace: cellular_component +def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] +synonym: "GM-CSF receptor complex" EXACT [GOC:vk] +synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0030527 +name: structural constituent of chromatin +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0030528 +name: obsolete transcription regulator activity +namespace: molecular_function +def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] +comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "transcription regulator activity" EXACT [] +synonym: "transcriptional regulator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0140110 + +[Term] +id: GO:0030530 +name: obsolete heterogeneous nuclear ribonucleoprotein complex +namespace: cellular_component +def: "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732] +comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity. +synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] +synonym: "heterogeneous nuclear ribonucleoprotein complex" EXACT [] +synonym: "hnRNP" EXACT [] +xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle +is_obsolete: true +consider: GO:0005681 +consider: GO:1990904 + +[Term] +id: GO:0030531 +name: obsolete small cytoplasmic ribonucleoprotein complex +namespace: cellular_component +def: "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] +comment: This term was made obsolete because it was not clearly defined. +synonym: "scRNP" EXACT [] +synonym: "small cytoplasmic ribonucleoprotein" EXACT [] +synonym: "small cytoplasmic ribonucleoprotein complex" EXACT [] +is_obsolete: true +replaced_by: GO:1990904 + +[Term] +id: GO:0030532 +name: small nuclear ribonucleoprotein complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] +subset: goslim_pir +synonym: "small nuclear ribonucleoprotein" EXACT [] +synonym: "snRNP" EXACT [] +xref: Wikipedia:SnRNP +is_a: GO:0120114 ! Sm-like protein family complex +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0030533 +name: triplet codon-amino acid adaptor activity +namespace: molecular_function +def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] +comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_yeast +synonym: "transfer RNA" RELATED [] +synonym: "tRNA" RELATED [] +is_a: GO:0003729 ! mRNA binding +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0030534 +name: adult behavior +namespace: biological_process +def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "adult behavioral response to stimulus" EXACT [] +synonym: "adult behaviour" EXACT [] +synonym: "adult behavioural response to stimulus" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030535 +name: obsolete adult feeding behavior (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "adult feeding behavior (sensu Insecta)" EXACT [] +is_obsolete: true +replaced_by: GO:0008343 + +[Term] +id: GO:0030536 +name: larval feeding behavior +namespace: biological_process +def: "Feeding behavior in a larval (immature) organism." [GOC:mah] +comment: See also the biological process term 'feeding behavior ; GO:0007631'. +synonym: "larval feeding behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior +is_a: GO:0030537 ! larval behavior + +[Term] +id: GO:0030537 +name: larval behavior +namespace: biological_process +alt_id: GO:0017037 +def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099] +comment: See also the biological process term 'behavior ; GO:0007610'. +synonym: "larval behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0030538 +name: embryonic genitalia morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] +synonym: "embryonic genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0048562 ! embryonic organ morphogenesis + +[Term] +id: GO:0030539 +name: male genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] +synonym: "male genital development" EXACT [] +is_a: GO:0048806 ! genitalia development +is_a: GO:0061458 ! reproductive system development +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0030540 +name: female genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] +synonym: "female genital development" EXACT [] +is_a: GO:0048806 ! genitalia development +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0030541 +name: plasmid partitioning +namespace: biological_process +alt_id: GO:0030542 +def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah] +is_a: GO:0006276 ! plasmid maintenance + +[Term] +id: GO:0030543 +name: 2-micrometer plasmid partitioning +namespace: biological_process +def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah] +is_a: GO:0030541 ! plasmid partitioning + +[Term] +id: GO:0030544 +name: Hsp70 protein binding +namespace: molecular_function +def: "Binding to a Hsp70 protein, heat shock proteins around 70kDa in size." [ISBN:0198506732] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0030545 +name: signaling receptor regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a receptor." [GOC:ceb] +synonym: "receptor regulator activity" BROAD [] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0030546 +name: signaling receptor activator activity +namespace: molecular_function +def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] +synonym: "receptor activator activity" BROAD [] +synonym: "signalling receptor activator activity" EXACT [] +is_a: GO:0030545 ! signaling receptor regulator activity + +[Term] +id: GO:0030547 +name: signaling receptor inhibitor activity +namespace: molecular_function +def: "Binds to and modulates the activity of a signaling receptor." [GOC:ceb] +synonym: "receptor inhibitor activity" BROAD [] +is_a: GO:0030545 ! signaling receptor regulator activity + +[Term] +id: GO:0030548 +name: acetylcholine receptor regulator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] +is_a: GO:0099602 ! neurotransmitter receptor regulator activity + +[Term] +id: GO:0030549 +name: acetylcholine receptor activator activity +namespace: molecular_function +def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] +is_a: GO:0030546 ! signaling receptor activator activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity + +[Term] +id: GO:0030550 +name: acetylcholine receptor inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of an acetylcholine receptor." [GOC:mah] +is_a: GO:0030547 ! signaling receptor inhibitor activity +is_a: GO:0030548 ! acetylcholine receptor regulator activity + +[Term] +id: GO:0030551 +name: cyclic nucleotide binding +namespace: molecular_function +def: "Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0030552 +name: cAMP binding +namespace: molecular_function +def: "Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] +synonym: "3',5' cAMP binding" EXACT [] +synonym: "3',5'-cAMP binding" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] +synonym: "cyclic AMP binding" EXACT [] +is_a: GO:0030551 ! cyclic nucleotide binding +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0030553 +name: cGMP binding +namespace: molecular_function +def: "Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] +synonym: "3',5' cGMP binding" EXACT [] +synonym: "3',5'-cGMP binding" EXACT [] +synonym: "cyclic GMP binding" EXACT [] +is_a: GO:0030551 ! cyclic nucleotide binding +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0030554 +name: adenyl nucleotide binding +namespace: molecular_function +def: "Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate." [ISBN:0198506732] +subset: goslim_chembl +is_a: GO:0017076 ! purine nucleotide binding + +[Term] +id: GO:0030555 +name: RNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +subset: goslim_yeast +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0030556 +name: rRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0019843 ! rRNA binding +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030557 +name: tRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0000049 ! tRNA binding +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030558 +name: RNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030559 +name: rRNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030556 ! rRNA modification guide activity +is_a: GO:0030558 ! RNA pseudouridylation guide activity + +[Term] +id: GO:0030560 +name: tRNA pseudouridylation guide activity +namespace: molecular_function +def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030557 ! tRNA modification guide activity +is_a: GO:0030558 ! RNA pseudouridylation guide activity + +[Term] +id: GO:0030561 +name: RNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030562 +name: rRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030556 ! rRNA modification guide activity +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity + +[Term] +id: GO:0030563 +name: snRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity +is_a: GO:0030566 ! snRNA modification guide activity + +[Term] +id: GO:0030564 +name: tRNA 2'-O-ribose methylation guide activity +namespace: molecular_function +def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0030557 ! tRNA modification guide activity +is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity + +[Term] +id: GO:0030565 +name: snRNA pseudouridylation guide activity +namespace: molecular_function +def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. +is_a: GO:0030558 ! RNA pseudouridylation guide activity +is_a: GO:0030566 ! snRNA modification guide activity + +[Term] +id: GO:0030566 +name: snRNA modification guide activity +namespace: molecular_function +def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] +comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. +is_a: GO:0017069 ! snRNA binding +is_a: GO:0030555 ! RNA modification guide activity + +[Term] +id: GO:0030567 +name: obsolete thrombin activator activity +namespace: molecular_function +def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb] +synonym: "thrombin activator activity" EXACT [] +is_obsolete: true +replaced_by: GO:0016504 + +[Term] +id: GO:0030568 +name: obsolete plasmin inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. +synonym: "plasmin inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004867 + +[Term] +id: GO:0030569 +name: obsolete chymotrypsin inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] +comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term. +synonym: "chymotrypsin inhibitor activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004867 + +[Term] +id: GO:0030570 +name: pectate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] +synonym: "(1->4)-alpha-D-galacturonan lyase activity" RELATED [EC:4.2.2.2] +synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" RELATED [EC:4.2.2.2] +synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" RELATED [EC:4.2.2.2] +synonym: "endogalacturonate transeliminase activity" RELATED [EC:4.2.2.2] +synonym: "endopectin methyltranseliminase activity" RELATED [EC:4.2.2.2] +synonym: "pectate transeliminase activity" RELATED [EC:4.2.2.2] +synonym: "pectic acid lyase activity" RELATED [EC:4.2.2.2] +synonym: "pectic acid transeliminase activity" RELATED [EC:4.2.2.2] +synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] +synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] +synonym: "PGA lyase activity" RELATED [EC:4.2.2.2] +synonym: "polygalacturonate lyase activity" RELATED [EC:4.2.2.2] +synonym: "polygalacturonic acid lyase activity" RELATED [EC:4.2.2.2] +synonym: "polygalacturonic acid trans-eliminase activity" RELATED [EC:4.2.2.2] +synonym: "polygalacturonic transeliminase activity" RELATED [EC:4.2.2.2] +synonym: "PPase-N activity" RELATED [EC:4.2.2.2] +xref: EC:4.2.2.2 +xref: MetaCyc:4.2.2.2-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0030572 +name: phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0030573 +name: bile acid catabolic process +namespace: biological_process +alt_id: GO:0019613 +def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] +synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] +synonym: "bile acid breakdown" EXACT [] +synonym: "bile acid catabolism" EXACT [] +synonym: "bile acid degradation" EXACT [] +synonym: "cholate catabolic process" NARROW [] +xref: MetaCyc:7ALPHADEHYDROX-PWY +is_a: GO:0008206 ! bile acid metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0030574 +name: collagen catabolic process +namespace: biological_process +def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] +synonym: "collagen breakdown" EXACT [] +synonym: "collagen catabolism" EXACT [] +synonym: "collagen degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0030575 +name: nuclear body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah] +synonym: "nuclear body organisation" EXACT [] +synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0030576 +name: Cajal body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] +comment: See also the cellular component term 'Cajal body ; GO:0015030'. +synonym: "Cajal body organisation" EXACT [] +synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030577 +name: Lands organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863] +comment: See also the cellular component term 'Lands ; GO:0016606'. +synonym: "Lands organisation" EXACT [] +synonym: "Lands organization and biogenesis" RELATED [GOC:mah] +synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030578 +name: PML body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078] +comment: See also the cellular component term 'PML body ; GO:0016605'. +synonym: "PML body organisation" EXACT [] +synonym: "PML body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0030579 +name: ubiquitin-dependent SMAD protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators] +synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT [] +synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT [] +synonym: "ubiquitin-dependent SMAD protein degradation" EXACT [] +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process +relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0030580 +name: quinone cofactor methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030581 +name: symbiont intracellular protein transport in host +namespace: biological_process +alt_id: GO:0051708 +def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] +synonym: "host cell protein transport" EXACT [] +synonym: "intracellular protein transport in host" EXACT [] +synonym: "intracellular protein transport in other organism during symbiotic interaction" BROAD [GOC:dph] +synonym: "intracellular protein transport in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0015031 ! protein transport +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0030582 +name: reproductive fruiting body development +namespace: biological_process +def: "The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores." [GOC:mah, GOC:mtg_sensu] +comment: This term describes the development of a fruiting body that is a spore-bearing organ. It is not intended to describe the development of myxococcal fruiting bodies. +synonym: "fruiting body formation" EXACT [] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0030583 +name: myxococcal fruiting body development +namespace: biological_process +alt_id: GO:0055084 +def: "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786] +comment: For example, as seen in myxobacterium. It is not intended to describe fruiting body development as is Dictyostelium. +synonym: "fruiting body development in cellular response to starvation" BROAD [] +synonym: "fruiting body development in response to starvation" BROAD [] +is_a: GO:0042594 ! response to starvation +is_a: GO:0044764 ! multi-organism cellular process + +[Term] +id: GO:0030584 +name: sporocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu] +synonym: "fruiting body development" BROAD [] +is_a: GO:0030582 ! reproductive fruiting body development + +[Term] +id: GO:0030585 +name: phosphoenolpyruvate carboxykinase (diphosphate) activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22356] +synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" RELATED [EC:4.1.1.38] +synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" RELATED [EC:4.1.1.38] +synonym: "PEP carboxyphosphotransferase activity" RELATED [EC:4.1.1.38] +synonym: "PEPCTrP" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38] +synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" RELATED [EC:4.1.1.38] +synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] +synonym: "phosphopyruvate carboxykinase (pyrophosphate)" RELATED [EC:4.1.1.38] +synonym: "phosphopyruvate carboxylase (pyrophosphate)" RELATED [EC:4.1.1.38] +xref: EC:4.1.1.38 +xref: KEGG_REACTION:R00346 +xref: MetaCyc:4.1.1.38-RXN +xref: RHEA:22356 +is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity + +[Term] +id: GO:0030586 +name: [methionine synthase] reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [RHEA:23908] +comment: Formerly EC:2.1.1.135. +synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] +synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] +synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" RELATED [EC:1.16.1.8] +synonym: "methionine synthase reductase activity" RELATED [EC:1.16.1.8] +synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" RELATED [EC:1.16.1.8] +synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.8] +xref: EC:1.16.1.8 +xref: MetaCyc:2.1.1.135-RXN +xref: Reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl" +xref: RHEA:23908 +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0030587 +name: sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4332228] +synonym: "fruiting body development" BROAD [] +synonym: "fruiting body formation" BROAD [] +synonym: "sorocarp biosynthesis" EXACT [] +synonym: "sorocarp formation" EXACT [] +is_a: GO:0099120 ! socially cooperative development + +[Term] +id: GO:0030588 +name: pseudocleavage +namespace: biological_process +def: "Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:30990821, PMID:7729583] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0030589 +name: pseudocleavage involved in syncytial blastoderm formation +namespace: biological_process +def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] +synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph] +is_a: GO:0030588 ! pseudocleavage +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0030590 +name: first cell cycle pseudocleavage +namespace: biological_process +def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583] +is_a: GO:0030588 ! pseudocleavage + +[Term] +id: GO:0030591 +name: 2'-deoxyguanosine DNA ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] +synonym: "NAD DNA ADP-ribosyltransferase activity" BROAD [] +is_a: GO:0140294 ! NAD DNA ADP-ribosyltransferase activity + +[Term] +id: GO:0030592 +name: DNA ADP-ribosylation +namespace: biological_process +def: "The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA." [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0030593 +name: neutrophil chemotaxis +namespace: biological_process +def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732] +is_a: GO:0071621 ! granulocyte chemotaxis +is_a: GO:1990266 ! neutrophil migration + +[Term] +id: GO:0030594 +name: neurotransmitter receptor activity +namespace: molecular_function +def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] +comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0030595 +name: leukocyte chemotaxis +namespace: biological_process +def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] +synonym: "immune cell chemotaxis" EXACT [] +synonym: "leucocyte chemotaxis" EXACT [] +is_a: GO:0050900 ! leukocyte migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0030596 +name: alpha-L-rhamnosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] +synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] +synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] +synonym: "alpha-L-rhamnoside rhamnohydrolase activity" RELATED [EC:3.2.1.40] +xref: EC:3.2.1.40 +xref: MetaCyc:3.2.1.40-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0030597 +name: RNA glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0030598 +name: rRNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] +synonym: "gelonin" RELATED [EC:3.2.2.22] +synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] +synonym: "momorcochin-S" RELATED [EC:3.2.2.22] +synonym: "nigrin b" RELATED [EC:3.2.2.22] +synonym: "ribosomal ribonucleate N-glycosidase activity" RELATED [EC:3.2.2.22] +synonym: "ricin" RELATED [EC:3.2.2.22] +synonym: "RNA N-glycosidase activity" RELATED [EC:3.2.2.22] +synonym: "rRNA N-glycohydrolase activity" RELATED [EC:3.2.2.22] +synonym: "rRNA N-glycosidase activity" EXACT [] +synonym: "saporins" RELATED [EC:3.2.2.22] +xref: EC:3.2.2.22 +xref: MetaCyc:3.2.2.22-RXN +is_a: GO:0030597 ! RNA glycosylase activity +is_a: GO:0140102 ! catalytic activity, acting on a rRNA + +[Term] +id: GO:0030599 +name: pectinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] +synonym: "pectase activity" RELATED [EC:3.1.1.11] +synonym: "pectin demethoxylase activity" RELATED [EC:3.1.1.11] +synonym: "pectin methoxylase activity" RELATED [EC:3.1.1.11] +synonym: "pectin methyl esterase activity" RELATED [EC:3.1.1.11] +synonym: "pectin methylesterase activity" EXACT [] +synonym: "pectin pectylhydrolase activity" RELATED [EC:3.1.1.11] +synonym: "pectinoesterase activity" RELATED [EC:3.1.1.11] +xref: EC:3.1.1.11 +xref: MetaCyc:PECTINESTERASE-RXN +xref: RHEA:22380 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0030600 +name: feruloyl esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] +synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" RELATED [EC:3.1.1.73] +synonym: "cinnAE" RELATED [EC:3.1.1.73] +synonym: "cinnamoyl ester hydrolase activity" EXACT [] +synonym: "FAE-I" RELATED [EC:3.1.1.73] +synonym: "FAE-II" RELATED [EC:3.1.1.73] +synonym: "FAE-III" RELATED [EC:3.1.1.73] +synonym: "FAEA" RELATED [EC:3.1.1.73] +synonym: "ferulic acid esterase activity" RELATED [EC:3.1.1.73] +synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] +synonym: "hydroxycinnamoyl esterase activity" RELATED [EC:3.1.1.73] +xref: EC:3.1.1.73 +xref: MetaCyc:3.1.1.73-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0030601 +name: obsolete aminopeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] +comment: This term was made obsolete because it represents a gene product. +synonym: "aminopeptidase B activity" EXACT [] +synonym: "arginyl aminopeptidase activity" EXACT [] +synonym: "arylamidase II" RELATED [EC:3.4.11.6] +synonym: "Cl--activated arginine aminopeptidase activity" RELATED [EC:3.4.11.6] +synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] +synonym: "L-arginine aminopeptidase activity" RELATED [EC:3.4.11.6] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0030602 +name: obsolete chymosin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] +comment: This term was made obsolete because it represents a gene product. +synonym: "chymosin activity" EXACT [] +synonym: "rennin" RELATED [EC:3.4.23.4] +synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0030603 +name: oxaloacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24432] +synonym: "oxalacetic hydrolase activity" RELATED [EC:3.7.1.1] +synonym: "oxaloacetate acetylhydrolase activity" RELATED [EC:3.7.1.1] +xref: EC:3.7.1.1 +xref: KEGG_REACTION:R00338 +xref: MetaCyc:OXALOACETASE-RXN +xref: RHEA:24432 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0030604 +name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13717] +synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" RELATED [EC:1.1.1.267] +synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" RELATED [EC:1.1.1.267] +synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" RELATED [EC:1.1.1.267] +synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" RELATED [EC:1.1.1.267] +synonym: "DOXP reductoisomerase activity" EXACT [] +synonym: "DXP-reductoisomerase activity" RELATED [EC:1.1.1.267] +xref: EC:1.1.1.267 +xref: KEGG_REACTION:R05688 +xref: MetaCyc:DXPREDISOM-RXN +xref: RHEA:13717 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0030611 +name: arsenate reductase activity +namespace: molecular_function +def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030612 +name: arsenate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737] +xref: MetaCyc:RXN-10737 +is_a: GO:0030611 ! arsenate reductase activity + +[Term] +id: GO:0030613 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] +synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] +xref: EC:1.20.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0030614 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] +synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] +xref: EC:1.20.4.- +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0030616 +name: obsolete transforming growth factor beta receptor, common-partner cytoplasmic mediator activity +namespace: molecular_function +def: "OBSOLETE. A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] +comment: This term was obsoleted because it is redundant with other terms. +synonym: "co-SMAD protein" RELATED [GOC:rl] +synonym: "common mediator SMAD protein" RELATED [GOC:rl] +synonym: "common partner SMAD protein" RELATED [GOC:rl] +synonym: "common-mediator SMAD protein" RELATED [GOC:rl] +synonym: "common-partner SMAD protein" RELATED [] +synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] +is_obsolete: true +consider: GO:0000981 +consider: GO:0003712 + +[Term] +id: GO:0030617 +name: obsolete transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity +namespace: molecular_function +def: "OBSOLETE. A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] +comment: This term was obsoleted because it represents the same activity as GO:0140416 ; DNA-binding transcription factor inhibitor activity', occurs_in cytosol. +synonym: "inhibitory SMAD protein" RELATED [] +synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] +is_obsolete: true +consider: GO:0140416 + +[Term] +id: GO:0030618 +name: obsolete transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity +namespace: molecular_function +def: "OBSOLETE. A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] +comment: This term was obsoleted because it is redundant with other terms. +synonym: "pathway restricted SMAD protein" RELATED [GOC:rl] +synonym: "pathway-restricted SMAD protein" RELATED [GOC:rl] +synonym: "pathway-specific SMAD protein" RELATED [] +synonym: "receptor regulated SMAD protein" RELATED [GOC:rl] +synonym: "receptor-regulated SMAD protein" RELATED [GOC:rl] +synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] +synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] +is_obsolete: true +consider: GO:0000981 +consider: GO:0003712 + +[Term] +id: GO:0030619 +name: U1 snRNA binding +namespace: molecular_function +def: "Binding to a U1 small nuclear RNA (U1 snRNA)." [GOC:mah] +comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030620 +name: U2 snRNA binding +namespace: molecular_function +def: "Binding to a U2 small nuclear RNA (U2 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030621 +name: U4 snRNA binding +namespace: molecular_function +def: "Binding to a U4 small nuclear RNA (U4 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030622 +name: U4atac snRNA binding +namespace: molecular_function +def: "Binding to a U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030623 +name: U5 snRNA binding +namespace: molecular_function +def: "Binding to a U5 small nuclear RNA (U5 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030624 +name: U6atac snRNA binding +namespace: molecular_function +def: "Binding to a U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030625 +name: U11 snRNA binding +namespace: molecular_function +def: "Binding to a U11 small nuclear RNA (U11 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030626 +name: U12 snRNA binding +namespace: molecular_function +def: "Binding to a U12 small nuclear RNA (U12 snRNA)." [GOC:jl] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0030627 +name: pre-mRNA 5'-splice site binding +namespace: molecular_function +def: "Binding to a pre-mRNA 5' splice site sequence." [GOC:jl] +synonym: "pre-mRNA 5' splice site binding" EXACT [] +is_a: GO:0036002 ! pre-mRNA binding + +[Term] +id: GO:0030628 +name: pre-mRNA 3'-splice site binding +namespace: molecular_function +def: "Binding to a pre-mRNA 3' splice site sequence." [GOC:jl] +synonym: "pre-mRNA 3' splice site binding" EXACT [] +is_a: GO:0036002 ! pre-mRNA binding + +[Term] +id: GO:0030629 +name: U6 snRNA 3'-end binding +namespace: molecular_function +def: "Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end." [GOC:mah] +comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). +synonym: "U6 snRNA 3' end binding" EXACT [] +is_a: GO:0017070 ! U6 snRNA binding + +[Term] +id: GO:0030631 +name: pyrrolysine incorporation +namespace: biological_process +def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321] +synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321] +synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [] +xref: RESID:AA0321 +is_a: GO:0006451 ! translational readthrough + +[Term] +id: GO:0030632 +name: D-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [GOC:jsg, GOC:mah] +synonym: "D-alanine anabolism" EXACT [] +synonym: "D-alanine biosynthesis" EXACT [] +synonym: "D-alanine formation" EXACT [] +synonym: "D-alanine synthesis" EXACT [] +is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process +is_a: GO:0046436 ! D-alanine metabolic process +is_a: GO:0046437 ! D-amino acid biosynthetic process + +[Term] +id: GO:0030633 +name: D-alanine family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah] +synonym: "D-alanine family amino acid breakdown" EXACT [] +synonym: "D-alanine family amino acid catabolism" EXACT [] +synonym: "D-alanine family amino acid degradation" EXACT [] +is_a: GO:0006524 ! alanine catabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process + +[Term] +id: GO:0030634 +name: carbon fixation by acetyl-CoA pathway +namespace: biological_process +def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093] +synonym: "acetyl CoA pathway" RELATED [GOC:cjm, PMID:14602585] +synonym: "Ljungdahl-Wood pathway" EXACT [] +synonym: "reductive acetyl CoA pathway" EXACT [GOC:cjm, PMID:18801467] +xref: MetaCyc:CODH-PWY +xref: Wikipedia:Wood-Ljungdahl_pathway +is_a: GO:0006085 ! acetyl-CoA biosynthetic process +is_a: GO:0015977 ! carbon fixation + +[Term] +id: GO:0030635 +name: obsolete acetate derivative metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah] +comment: This term was made obsolete because it is an unnecessary grouping term, and has been replaced by terms to describe metabolism of specific compounds. +synonym: "acetate derivative metabolic process" EXACT [] +synonym: "acetate derivative metabolism" EXACT [] +is_obsolete: true +consider: GO:1900619 + +[Term] +id: GO:0030636 +name: obsolete acetate derivative biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah] +comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. +synonym: "acetate derivative anabolism" EXACT [] +synonym: "acetate derivative biosynthesis" EXACT [] +synonym: "acetate derivative biosynthetic process" EXACT [] +synonym: "acetate derivative formation" EXACT [] +synonym: "acetate derivative synthesis" EXACT [] +is_obsolete: true +consider: GO:1900620 + +[Term] +id: GO:0030637 +name: obsolete acetate derivative catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai] +comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. +synonym: "acetate derivative breakdown" EXACT [] +synonym: "acetate derivative catabolic process" EXACT [] +synonym: "acetate derivative catabolism" EXACT [] +synonym: "acetate derivative degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030638 +name: polyketide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] +synonym: "polyketide metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0030639 +name: polyketide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] +synonym: "polyketide anabolism" EXACT [] +synonym: "polyketide biosynthesis" EXACT [] +synonym: "polyketide formation" EXACT [] +synonym: "polyketide synthesis" EXACT [] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0030640 +name: polyketide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] +synonym: "polyketide breakdown" EXACT [] +synonym: "polyketide catabolism" EXACT [] +synonym: "polyketide degradation" EXACT [] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0030641 +name: regulation of cellular pH +namespace: biological_process +def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] +synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] +synonym: "proton homeostasis" EXACT [] +is_a: GO:0006885 ! regulation of pH +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis + +[Term] +id: GO:0030642 +name: cellular sulfate ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah] +synonym: "sulphate ion homeostasis" BROAD [] +is_a: GO:0055063 ! sulfate ion homeostasis +is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis + +[Term] +id: GO:0030643 +name: cellular phosphate ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah] +is_a: GO:0055062 ! phosphate ion homeostasis +is_a: GO:0072502 ! cellular trivalent inorganic anion homeostasis + +[Term] +id: GO:0030644 +name: cellular chloride ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah] +is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis +is_a: GO:0055064 ! chloride ion homeostasis + +[Term] +id: GO:0030645 +name: glucose catabolic process to butyrate +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732] +synonym: "butyrate fermentation" EXACT [] +synonym: "glucose fermentation to butyrate" EXACT [] +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0006113 ! fermentation +is_a: GO:1902705 ! hexose catabolic process to butyrate + +[Term] +id: GO:0030647 +name: aminoglycoside antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] +synonym: "aminoglycoside antibiotic metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:0030648 +name: aminoglycoside antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] +synonym: "aminoglycoside antibiotic anabolism" EXACT [] +synonym: "aminoglycoside antibiotic biosynthesis" EXACT [] +synonym: "aminoglycoside antibiotic formation" EXACT [] +synonym: "aminoglycoside antibiotic synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0030649 +name: aminoglycoside antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] +synonym: "aminoglycoside antibiotic breakdown" EXACT [] +synonym: "aminoglycoside antibiotic catabolism" EXACT [] +synonym: "aminoglycoside antibiotic degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0030650 +name: peptide antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah] +synonym: "peptide antibiotic metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0016999 ! antibiotic metabolic process + +[Term] +id: GO:0030651 +name: peptide antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah] +synonym: "peptide antibiotic anabolism" EXACT [] +synonym: "peptide antibiotic biosynthesis" EXACT [] +synonym: "peptide antibiotic formation" EXACT [] +synonym: "peptide antibiotic synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030650 ! peptide antibiotic metabolic process +is_a: GO:0043043 ! peptide biosynthetic process + +[Term] +id: GO:0030652 +name: peptide antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah] +synonym: "peptide antibiotic breakdown" EXACT [] +synonym: "peptide antibiotic catabolism" EXACT [] +synonym: "peptide antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030650 ! peptide antibiotic metabolic process +is_a: GO:0043171 ! peptide catabolic process + +[Term] +id: GO:0030653 +name: beta-lactam antibiotic metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] +synonym: "beta-lactam antibiotic metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0044106 ! cellular amine metabolic process +is_a: GO:0072338 ! cellular lactam metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0030654 +name: beta-lactam antibiotic biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] +synonym: "beta-lactam antibiotic anabolism" EXACT [] +synonym: "beta-lactam antibiotic biosynthesis" EXACT [] +synonym: "beta-lactam antibiotic formation" EXACT [] +synonym: "beta-lactam antibiotic synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process +is_a: GO:0072339 ! cellular lactam biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0030655 +name: beta-lactam antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] +synonym: "beta-lactam antibiotic breakdown" EXACT [] +synonym: "beta-lactam antibiotic catabolism" EXACT [] +synonym: "beta-lactam antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process +is_a: GO:0072340 ! cellular lactam catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0030656 +name: regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] +synonym: "regulation of vitamin metabolism" EXACT [] +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0030657 +name: obsolete regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT [] +is_obsolete: true +consider: GO:0051199 + +[Term] +id: GO:0030658 +name: transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] +synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "secretory vesicle membrane" BROAD [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0030133 ! transport vesicle + +[Term] +id: GO:0030659 +name: cytoplasmic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] +is_a: GO:0012506 ! vesicle membrane +relationship: part_of GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0030660 +name: Golgi-associated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] +synonym: "Golgi vesicle membrane" RELATED [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005798 ! Golgi-associated vesicle + +[Term] +id: GO:0030661 +name: chitosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a chitosome." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0045009 ! chitosome + +[Term] +id: GO:0030662 +name: coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0030135 ! coated vesicle + +[Term] +id: GO:0030663 +name: COPI-coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] +synonym: "COPI coated vesicle membrane" EXACT [GOC:sl] +is_a: GO:0030660 ! Golgi-associated vesicle membrane +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0030665 +name: clathrin-coated vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] +synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl] +is_a: GO:0030662 ! coated vesicle membrane +relationship: part_of GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0030666 +name: endocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0030667 +name: secretory granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] +synonym: "secretory vesicle membrane" BROAD [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0030141 ! secretory granule + +[Term] +id: GO:0030668 +name: merozoite dense granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0020026 ! merozoite dense granule + +[Term] +id: GO:0030669 +name: clathrin-coated endocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] +is_a: GO:0030665 ! clathrin-coated vesicle membrane +is_a: GO:0030666 ! endocytic vesicle membrane +relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle + +[Term] +id: GO:0030670 +name: phagocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] +synonym: "phagosome membrane" EXACT [GOC:mah] +is_a: GO:0030666 ! endocytic vesicle membrane +relationship: part_of GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0030671 +name: clathrin-coated phagocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] +is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane +is_a: GO:0030670 ! phagocytic vesicle membrane +relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle + +[Term] +id: GO:0030672 +name: synaptic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] +subset: goslim_synapse +is_a: GO:0099501 ! exocytic vesicle membrane +relationship: part_of GO:0008021 ! synaptic vesicle + +[Term] +id: GO:0030673 +name: axolemma +namespace: cellular_component +def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] +synonym: "axonal membrane" EXACT [GOC:vk] +xref: NIF_Subcellular:sao250772229 +xref: Wikipedia:Axolemma +is_a: GO:0032589 ! neuron projection membrane +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0030674 +name: protein-macromolecule adaptor activity +namespace: molecular_function +def: "The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid." [GOC:bf, GOC:mah, GOC:vw] +subset: goslim_chembl +subset: goslim_yeast +synonym: "protein binding, bridging" EXACT [] +synonym: "protein-protein adaptor" NARROW [] +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0030677 +name: ribonuclease P complex +namespace: cellular_component +def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] +comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. +subset: goslim_pir +synonym: "RNase P complex" EXACT [] +is_a: GO:1902555 ! endoribonuclease complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0030678 +name: mitochondrial ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans." [GOC:mah, PMID:12045094, PMID:27187488] +synonym: "mitochondrial RNase P complex" EXACT [] +is_a: GO:0030677 ! ribonuclease P complex +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0030679 +name: cyanelle ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] +synonym: "cyanelle RNase P complex" EXACT [] +is_a: GO:0030681 ! multimeric ribonuclease P complex +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0030680 +name: dimeric ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094] +synonym: "dimeric RNase P complex" EXACT [] +is_a: GO:0030677 ! ribonuclease P complex + +[Term] +id: GO:0030681 +name: multimeric ribonuclease P complex +namespace: cellular_component +def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094] +synonym: "multimeric RNase P complex" EXACT [] +is_a: GO:0030677 ! ribonuclease P complex + +[Term] +id: GO:0030682 +name: mitigation of host defenses by symbiont +namespace: biological_process +alt_id: GO:0044413 +alt_id: GO:0044415 +alt_id: GO:0051807 +alt_id: GO:0051832 +alt_id: GO:0051834 +def: "A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "avoidance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "avoidance of defenses of other organism involved in symbiotic interaction" NARROW [] +synonym: "avoidance of host defences" NARROW [] +synonym: "avoidance of host defenses" NARROW [] +synonym: "evasion of host defence response" NARROW [] +synonym: "evasion of other organism defence response" NARROW [] +synonym: "evasion or tolerance of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "evasion or tolerance of defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "evasion or tolerance of defenses of other organism" RELATED [] +synonym: "evasion or tolerance of defenses of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "evasion or tolerance of defenses of other organism involved in symbiotic interaction" RELATED [] +synonym: "evasion or tolerance of host defense response" NARROW [] +synonym: "evasion or tolerance of host defenses" RELATED [] +is_a: GO:0052200 ! response to host defenses + +[Term] +id: GO:0030683 +name: mitigation of host immune response by virus +namespace: biological_process +alt_id: GO:0019052 +alt_id: GO:0019053 +def: "A process by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah, GOC:pk] +synonym: "evasion by virus of host immune response" NARROW [GOC:bf, GOC:bm, GOC:jl] +synonym: "evasion or tolerance by virus of host immune response" RELATED [] +synonym: "inhibition of extracellular antiviral response" EXACT [] +synonym: "mitigation by virus of host immune response" EXACT [] +synonym: "negative regulation by virus of extracellular antiviral response" EXACT [] +synonym: "negative regulation by virus of intracellular antiviral response" EXACT [] +synonym: "negative regulation of host extracellular antiviral response by virus" EXACT [] +synonym: "negative regulation of host intracellular antiviral response by virus" EXACT [] +synonym: "suppression by virus of host extracellular antiviral response" EXACT [] +synonym: "suppression by virus of host immune response" NARROW [GOC:bf] +synonym: "suppression by virus of host intracellular antiviral response" EXACT [] +synonym: "suppression of host extracellular antiviral response by virus" EXACT [] +synonym: "suppression of host intracellular antiviral response by virus" EXACT [] +synonym: "viral inhibition of intracellular antiviral response" EXACT [] +is_a: GO:0019049 ! mitigation of host defenses by virus +is_a: GO:0050690 ! regulation of defense response to virus by virus + +[Term] +id: GO:0030684 +name: preribosome +namespace: cellular_component +def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] +subset: goslim_pir +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0030685 +name: nucleolar preribosome +namespace: cellular_component +def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] +is_a: GO:0030684 ! preribosome +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0030686 +name: 90S preribosome +namespace: cellular_component +def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030687 +name: preribosome, large subunit precursor +namespace: cellular_component +def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] +comment: Note that this complex is 66S in Saccharomyces. +synonym: "66S preribosome" NARROW [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030688 +name: preribosome, small subunit precursor +namespace: cellular_component +def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] +comment: Note that this complex is 43S in Saccharomyces. +synonym: "43S preribosome" NARROW [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0030689 +name: Noc complex +namespace: cellular_component +def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] +comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0030690 +name: Noc1p-Noc2p complex +namespace: cellular_component +def: "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671] +comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0030689 ! Noc complex +relationship: part_of GO:0030686 ! 90S preribosome +relationship: part_of GO:0030687 ! preribosome, large subunit precursor + +[Term] +id: GO:0030691 +name: Noc2p-Noc3p complex +namespace: cellular_component +def: "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] +comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0030689 ! Noc complex +relationship: part_of GO:0030687 ! preribosome, large subunit precursor + +[Term] +id: GO:0030692 +name: Noc4p-Nop14p complex +namespace: cellular_component +def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] +comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah] +synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671] +is_a: GO:0030689 ! Noc complex +relationship: part_of GO:0030686 ! 90S preribosome +relationship: part_of GO:0030688 ! preribosome, small subunit precursor + +[Term] +id: GO:0030693 +name: obsolete caspase activity +namespace: molecular_function +alt_id: GO:0004199 +def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] +comment: This term was made obsolete because it represents a gene product. +synonym: "caspase activity" EXACT [] +synonym: "caspase-1 activity" NARROW [] +synonym: "caspase-10 activity" NARROW [] +synonym: "caspase-2 activity" NARROW [] +synonym: "caspase-3 activity" NARROW [] +synonym: "caspase-4 activity" NARROW [] +synonym: "caspase-5 activity" NARROW [] +synonym: "caspase-6 activity" NARROW [] +synonym: "caspase-7 activity" NARROW [] +synonym: "caspase-8 activity" NARROW [] +synonym: "caspase-9 activity" NARROW [] +synonym: "effector caspase activity" NARROW [] +synonym: "signaling (initiator) caspase activity" NARROW [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0030694 +name: bacterial-type flagellum basal body, rod +namespace: cellular_component +def: "The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] +synonym: "flagellar basal body, rod" EXACT [] +synonym: "flagellin-based flagellum basal body, rod" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009425 ! bacterial-type flagellum basal body + +[Term] +id: GO:0030695 +name: GTPase regulator activity +namespace: molecular_function +alt_id: GO:0005083 +def: "Binds to and modulates the activity of a GTPase." [GOC:mah] +synonym: "small GTPase regulator activity" RELATED [] +synonym: "small GTPase regulatory/interacting protein activity" RELATED [] +is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity + +[Term] +id: GO:0030696 +name: tRNA (m5U54) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337] +comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. +synonym: "RUMT" EXACT [] +is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity + +[Term] +id: GO:0030697 +name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity +namespace: molecular_function +alt_id: GO:0009021 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337] +synonym: "M5U-methyltransferase activity" RELATED [EC:2.1.1.35] +synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] +synonym: "RUMT" BROAD [] +synonym: "RUMT activity" RELATED [EC:2.1.1.35] +synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" RELATED [EC:2.1.1.35] +synonym: "transfer RNA uracil 5-methyltransferase activity" RELATED [EC:2.1.1.35] +synonym: "transfer RNA uracil methylase activity" RELATED [EC:2.1.1.35] +synonym: "tRNA (uracil-5-)-methyltransferase activity" EXACT [] +synonym: "tRNA uracil 5-methyltransferase activity" RELATED [EC:2.1.1.35] +synonym: "tRNA:m(5)U54-methyltransferase activity" RELATED [EC:2.1.1.35] +synonym: "tRNA:m5U54-methyltransferase activity" RELATED [EC:2.1.1.35] +xref: EC:2.1.1.35 +xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN +xref: RHEA:42712 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity + +[Term] +id: GO:0030698 +name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337] +synonym: "RUMT" BROAD [] +is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0030699 +name: glycine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12232] +synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" RELATED [EC:1.21.4.2] +xref: EC:1.21.4.2 +xref: KEGG_REACTION:R07226 +xref: MetaCyc:RXN-7566 +xref: RHEA:12232 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0030700 +name: glycine reductase complex +namespace: cellular_component +def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0030701 +name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] +synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" RELATED [EC:2.4.2.37] +synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" RELATED [EC:2.4.2.37] +synonym: "NAD-azoferredoxin (ADPribose)transferase activity" RELATED [EC:2.4.2.37] +synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.37 +xref: MetaCyc:2.4.2.37-RXN +xref: RHEA:18077 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0030703 +name: eggshell formation +namespace: biological_process +def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030704 +name: vitelline membrane formation +namespace: biological_process +def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0035803 ! egg coat formation +is_a: GO:0085029 ! extracellular matrix assembly + +[Term] +id: GO:0030705 +name: cytoskeleton-dependent intracellular transport +namespace: biological_process +def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] +subset: goslim_chembl +subset: goslim_drosophila +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0030706 +name: germarium-derived oocyte differentiation +namespace: biological_process +def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "oocyte cell differentiation" RELATED [] +is_a: GO:0009994 ! oocyte differentiation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030707 +name: ovarian follicle cell development +namespace: biological_process +def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] +is_a: GO:0002064 ! epithelial cell development +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030708 +name: germarium-derived female germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] +is_a: GO:0048139 ! female germ-line cyst encapsulation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030709 +name: border follicle cell delamination +namespace: biological_process +def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] +synonym: "border cell delamination" BROAD [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0060232 ! delamination +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030710 +name: regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "regulation of border cell delamination" BROAD [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030711 +name: positive regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "activation of border follicle cell delamination" NARROW [] +synonym: "positive regulation of border cell delamination" BROAD [] +synonym: "stimulation of border follicle cell delamination" NARROW [] +synonym: "up regulation of border follicle cell delamination" EXACT [] +synonym: "up-regulation of border follicle cell delamination" EXACT [] +synonym: "upregulation of border follicle cell delamination" EXACT [] +is_a: GO:0030710 ! regulation of border follicle cell delamination +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030712 +name: negative regulation of border follicle cell delamination +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261] +synonym: "down regulation of border follicle cell delamination" EXACT [] +synonym: "down-regulation of border follicle cell delamination" EXACT [] +synonym: "downregulation of border follicle cell delamination" EXACT [] +synonym: "inhibition of border follicle cell delamination" NARROW [] +synonym: "negative regulation of border cell delamination" BROAD [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0030710 ! regulation of border follicle cell delamination +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0030709 ! border follicle cell delamination + +[Term] +id: GO:0030713 +name: ovarian follicle cell stalk formation +namespace: biological_process +def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030714 +name: anterior/posterior axis specification, follicular epithelium +namespace: biological_process +def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] +synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009798 ! axis specification +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0030707 ! ovarian follicle cell development + +[Term] +id: GO:0030715 +name: oocyte growth in germarium-derived egg chamber +namespace: biological_process +def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +is_a: GO:0001555 ! oocyte growth +relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber + +[Term] +id: GO:0030716 +name: oocyte fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "oocyte cell fate determination" EXACT [] +is_a: GO:0001709 ! cell fate determination + +[Term] +id: GO:0030717 +name: oocyte karyosome formation +namespace: biological_process +def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] +is_a: GO:0061988 ! karyosome formation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0030718 +name: germ-line stem cell population maintenance +namespace: biological_process +def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] +is_a: GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:0030719 +name: P granule organization +namespace: biological_process +alt_id: GO:0048114 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] +synonym: "P granule organization and biogenesis" RELATED [] +synonym: "polar granule organisation" EXACT [] +synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006996 ! organelle organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007315 ! pole plasm assembly + +[Term] +id: GO:0030720 +name: oocyte localization involved in germarium-derived egg chamber formation +namespace: biological_process +def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] +synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] +synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] +synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] +synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte localization during oogenesis" RELATED [] +synonym: "oocyte positioning during oogenesis" NARROW [] +synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] +synonym: "oogenesis, oocyte localization" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051674 ! localization of cell +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030721 +name: spectrosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] +synonym: "spectrosome organisation" EXACT [] +synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0030723 +name: ovarian fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "ovarian fusome organisation" EXACT [] +synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045478 ! fusome organization +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030724 +name: testicular fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] +synonym: "testicular fusome organisation" EXACT [] +synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045478 ! fusome organization +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0030725 +name: germline ring canal formation +namespace: biological_process +def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] +synonym: "ring canal formation" BROAD [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0043063 ! intercellular bridge organization + +[Term] +id: GO:0030726 +name: male germline ring canal formation +namespace: biological_process +def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] +synonym: "spermatocyte ring canal formation" NARROW [] +synonym: "testicular ring canal formation" NARROW [] +is_a: GO:0030725 ! germline ring canal formation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0030727 +name: germarium-derived female germ-line cyst formation +namespace: biological_process +def: "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] +synonym: "germarium-derived female germline cyst formation" EXACT [] +is_a: GO:0048135 ! female germ-line cyst formation +relationship: part_of GO:0007293 ! germarium-derived egg chamber formation + +[Term] +id: GO:0030728 +name: ovulation +namespace: biological_process +def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] +xref: Wikipedia:Ovulation +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0030729 +name: acetoacetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16117] +synonym: "acetoacetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.16] +synonym: "acetoacetyl-CoA synthetase activity" EXACT [] +xref: EC:6.2.1.16 +xref: KEGG_REACTION:R01357 +xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN +xref: Reactome:R-HSA-5694494 "AACS ligates CoA-SH to ACA, forming ACA-CoA" +xref: RHEA:16117 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0030730 +name: sequestering of triglyceride +namespace: biological_process +def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] +synonym: "retention of triacylglycerol" EXACT [] +synonym: "retention of triglyceride" EXACT [] +synonym: "sequestering of triacylglycerol" EXACT [] +synonym: "sequestration of triacylglycerol" EXACT [] +synonym: "sequestration of triglyceride" EXACT [] +synonym: "storage of triacylglycerol" EXACT [] +synonym: "storage of triglyceride" EXACT [] +synonym: "triacylglycerol retention" EXACT [] +synonym: "triacylglycerol sequestering" EXACT [] +synonym: "triacylglycerol sequestration" EXACT [] +synonym: "triacylglycerol storage" EXACT [] +synonym: "triglyceride retention" EXACT [] +synonym: "triglyceride sequestering" EXACT [] +synonym: "triglyceride sequestration" EXACT [] +synonym: "triglyceride storage" EXACT [] +is_a: GO:0019915 ! lipid storage + +[Term] +id: GO:0030731 +name: guanidinoacetate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10656] +synonym: "GA methylpherase activity" RELATED [EC:2.1.1.2] +synonym: "guanidinoacetate methyltransferase activity" RELATED [EC:2.1.1.2] +synonym: "guanidinoacetate transmethylase activity" RELATED [EC:2.1.1.2] +synonym: "guanidoacetate methyltransferase activity" RELATED [EC:2.1.1.2] +synonym: "methionine-guanidinoacetic transmethylase activity" RELATED [EC:2.1.1.2] +synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" RELATED [EC:2.1.1.2] +xref: EC:2.1.1.2 +xref: KEGG_REACTION:R01883 +xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN +xref: RHEA:10656 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030732 +name: methionine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] +synonym: "methionine methyltransferase activity" RELATED [EC:2.1.1.12] +synonym: "S-adenosyl methionine:methionine methyl transferase activity" RELATED [EC:2.1.1.12] +synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" RELATED [EC:2.1.1.12] +synonym: "S-adenosylmethionine transmethylase activity" RELATED [EC:2.1.1.12] +synonym: "S-adenosylmethionine-methionine methyltransferase activity" RELATED [EC:2.1.1.12] +xref: EC:2.1.1.12 +xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN +xref: RHEA:13761 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030733 +name: fatty acid O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] +synonym: "fatty acid methyltransferase activity" RELATED [EC:2.1.1.15] +synonym: "fatty-acid O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" RELATED [EC:2.1.1.15] +xref: EC:2.1.1.15 +xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN +xref: RHEA:23012 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030734 +name: polysaccharide O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] +synonym: "acylpolysacharide 6-methyltransferase activity" RELATED [EC:2.1.1.18] +synonym: "polysaccharide methyltransferase activity" RELATED [EC:2.1.1.18] +synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" RELATED [EC:2.1.1.18] +xref: EC:2.1.1.18 +xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030735 +name: carnosine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14205] +synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" RELATED [EC:2.1.1.22] +xref: EC:2.1.1.22 +xref: KEGG_REACTION:R02144 +xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-8876789 "CARNMT1 methylates CARN to Anserine" +xref: RHEA:14205 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030736 +name: phenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14809] +synonym: "PMT" RELATED [EC:2.1.1.25] +synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" RELATED [EC:2.1.1.25] +xref: EC:2.1.1.25 +xref: KEGG_REACTION:R01239 +xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN +xref: RHEA:14809 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030737 +name: iodophenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14313] +synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" RELATED [EC:2.1.1.26] +xref: EC:2.1.1.26 +xref: KEGG_REACTION:R03746 +xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN +xref: RHEA:14313 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030738 +name: tyramine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14865] +synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" RELATED [EC:2.1.1.27] +synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" RELATED [EC:2.1.1.27] +synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" RELATED [EC:2.1.1.27] +synonym: "tyramine methylpherase activity" RELATED [EC:2.1.1.27] +xref: EC:2.1.1.27 +xref: KEGG_REACTION:R02384 +xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN +xref: RHEA:14865 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030739 +name: O-demethylpuromycin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] +synonym: "O-demethylpuromycin methyltransferase activity" RELATED [EC:2.1.1.38] +synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" RELATED [EC:2.1.1.38] +xref: EC:2.1.1.38 +xref: MetaCyc:2.1.1.38-RXN +xref: RHEA:22280 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030740 +name: inositol 3-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18877] +synonym: "inositol L-1-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" RELATED [EC:2.1.1.39] +synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] +synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] +xref: EC:2.1.1.39 +xref: KEGG_REACTION:R01189 +xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN +xref: RHEA:18877 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030741 +name: inositol 1-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17565] +synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" RELATED [EC:2.1.1.40] +synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "inositol D-1-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] +synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] +xref: EC:2.1.1.40 +xref: KEGG_REACTION:R01188 +xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN +xref: RHEA:17565 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030742 +name: GTP-dependent protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc] +comment: This term may be used to annotate both partners in a GTP-dependent binding interaction, both the GTP-bound protein and the protein(s) which interact with it. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030743 +name: rRNA (adenosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.230] +synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" RELATED [EC:2.1.1.230] +synonym: "RNA-pentose methylase activity" RELATED [] +synonym: "rRNA adenosine 2'-methylase activity" RELATED [EC:2.1.1.230] +synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" RELATED [EC:2.1.1.230] +synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.230] +xref: EC:2.1.1.230 +xref: MetaCyc:2.1.1.66-RXN +xref: RHEA:43212 +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0030744 +name: luteolin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14589] +synonym: "luteolin 3'-O-methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "luteolin methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "o-dihydric phenol meta-O-methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "o-dihydric phenol methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "o-diphenol m-O-methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" RELATED [EC:2.1.1.42] +synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" RELATED [EC:2.1.1.42] +xref: EC:2.1.1.42 +xref: KEGG_REACTION:R03587 +xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN +xref: RHEA:14589 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030745 +name: dimethylhistidine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44] +synonym: "dimethylhistidine methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" RELATED [EC:2.1.1.44] +xref: EC:2.1.1.44 +xref: KEGG_REACTION:R04436 +xref: MetaCyc:2.1.1.44-RXN +xref: RHEA:11104 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030746 +name: isoflavone 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] +synonym: "4'-hydroxyisoflavone methyltransferase activity" RELATED [EC:2.1.1.46] +synonym: "isoflavone methyltransferase activity" RELATED [EC:2.1.1.46] +synonym: "isoflavone O-methyltransferase activity" RELATED [EC:2.1.1.46] +synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.46] +xref: EC:2.1.1.46 +xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN +xref: RHEA:31739 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030747 +name: indolepyruvate C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] +synonym: "indolepyruvate 3-methyltransferase activity" RELATED [EC:2.1.1.47] +synonym: "indolepyruvate methyltransferase activity" RELATED [EC:2.1.1.47] +synonym: "indolepyruvic acid methyltransferase activity" RELATED [EC:2.1.1.47] +synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" RELATED [EC:2.1.1.47] +synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" RELATED [EC:2.1.1.47] +xref: EC:2.1.1.47 +xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN +xref: RHEA:12112 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030748 +name: amine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] +synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] +synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] +synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" RELATED [EC:2.1.1.49] +synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] +synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] +xref: EC:2.1.1.49 +xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030749 +name: loganate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] +synonym: "loganate methyltransferase activity" RELATED [EC:2.1.1.50] +synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" RELATED [EC:2.1.1.50] +synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" RELATED [EC:2.1.1.50] +xref: EC:2.1.1.50 +xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN +xref: RHEA:12508 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030750 +name: putrescine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15037] +synonym: "putrescine methyltransferase activity" RELATED [EC:2.1.1.53] +synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" RELATED [EC:2.1.1.53] +xref: EC:2.1.1.53 +xref: KEGG_REACTION:R01153 +xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN +xref: RHEA:15037 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030751 +name: licodione 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18521] +synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" RELATED [EC:2.1.1.65] +xref: EC:2.1.1.65 +xref: KEGG_REACTION:R03623 +xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN +xref: RHEA:18521 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030752 +name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0030764 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] +synonym: "bergaptol 5-O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "bergaptol methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "bergaptol O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "BMT activity" RELATED [EC:2.1.1.69] +synonym: "furanocoumarin 5-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "furanocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" RELATED [EC:2.1.1.69] +synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" RELATED [EC:2.1.1.69] +xref: EC:2.1.1.69 +xref: MetaCyc:2.1.1.69-RXN +xref: RHEA:11808 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030753 +name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0030765 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70] +synonym: "furanocoumarin 8-methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "furanocoumarin 8-O-methyl-transferase activity" RELATED [EC:2.1.1.70] +synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "xanthotoxol 8-O-methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "xanthotoxol methyltransferase activity" RELATED [EC:2.1.1.70] +synonym: "xanthotoxol O-methyltransferase activity" EXACT [] +synonym: "XMT activity" RELATED [EC:2.1.1.70] +xref: EC:2.1.1.70 +xref: KEGG_REACTION:R02982 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030754 +name: apigenin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] +synonym: "flavonoid methyltransferase activity" RELATED [EC:2.1.1.75] +synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] +synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.75] +xref: EC:2.1.1.75 +xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN +xref: RHEA:20429 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030755 +name: quercetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] +synonym: "flavonoid 3-methyltransferase activity" RELATED [EC:2.1.1.76] +synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] +synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] +xref: EC:2.1.1.76 +xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN +xref: RHEA:17673 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030756 +name: isoorientin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24096] +synonym: "isoorientin 3'-methyltransferase activity" RELATED [EC:2.1.1.78] +synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" RELATED [EC:2.1.1.78] +xref: EC:2.1.1.78 +xref: KEGG_REACTION:R03731 +xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN +xref: RHEA:24096 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030757 +name: 3-methylquercitin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16181] +synonym: "3-methylquercetin 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "7-OMT activity" RELATED [EC:2.1.1.82] +synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] +synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] +xref: EC:2.1.1.82 +xref: KEGG_REACTION:R05323 +xref: MetaCyc:2.1.1.82-RXN +xref: RHEA:16181 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030758 +name: 3,7-dimethylquercitin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21832] +synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] +synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] +synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] +xref: EC:2.1.1.83 +xref: KEGG_REACTION:R03456 +xref: MetaCyc:2.1.1.83-RXN +xref: RHEA:21832 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030759 +name: methylquercetagetin 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18717] +synonym: "6-OMT" RELATED [EC:2.1.1.84] +synonym: "flavonol 6-methyltransferase activity" RELATED [EC:2.1.1.84] +synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] +synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] +xref: EC:2.1.1.84 +xref: KEGG_REACTION:R04505 +xref: MetaCyc:2.1.1.84-RXN +xref: RHEA:18717 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030760 +name: pyridine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16893] +synonym: "pyridine methyltransferase activity" RELATED [EC:2.1.1.87] +synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" RELATED [EC:2.1.1.87] +xref: EC:2.1.1.87 +xref: KEGG_REACTION:R02862 +xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-175987 "NNMT transfers CH3 from AdoMet to PY" +xref: RHEA:16893 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030761 +name: 8-hydroxyquercitin 8-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16593] +synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] +synonym: "flavonol 8-methyltransferase activity" RELATED [EC:2.1.1.88] +synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] +synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] +xref: EC:2.1.1.88 +xref: KEGG_REACTION:R04398 +xref: MetaCyc:2.1.1.88-RXN +xref: RHEA:16593 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030762 +name: tetrahydrocolumbamine 2-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22536] +synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" RELATED [EC:2.1.1.89] +synonym: "tetrahydrocolumbamine methyltransferase activity" RELATED [EC:2.1.1.89] +xref: EC:2.1.1.89 +xref: KEGG_REACTION:R04077 +xref: MetaCyc:2.1.1.89-RXN +xref: RHEA:22536 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030763 +name: isobutyraldoxime O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10996] +synonym: "aldoxime methyltransferase activity" RELATED [EC:2.1.1.91] +synonym: "aldoxime O-methyltransferase activity" RELATED [EC:2.1.1.91] +synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" RELATED [EC:2.1.1.91] +synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" RELATED [EC:2.1.1.91] +xref: EC:2.1.1.91 +xref: KEGG_REACTION:R04169 +xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN +xref: RHEA:10996 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030766 +name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] +synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" RELATED [EC:2.1.1.94] +synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" RELATED [EC:2.1.1.94] +synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" RELATED [EC:2.1.1.94] +synonym: "tabersonine 16-O-methyltransferase activity" RELATED [EC:2.1.1.94] +xref: EC:2.1.1.94 +xref: MetaCyc:2.1.1.94-RXN +xref: RHEA:20992 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030767 +name: 3-hydroxyanthranilate 4-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17833] +synonym: "3-hydroxyanthranilate 4-methyltransferase activity" RELATED [EC:2.1.1.97] +synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" RELATED [EC:2.1.1.97] +xref: EC:2.1.1.97 +xref: KEGG_REACTION:R02667 +xref: MetaCyc:2.1.1.97-RXN +xref: RHEA:17833 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030768 +name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11336] +synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" RELATED [EC:2.1.1.99] +synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99] +synonym: "NMT activity" RELATED [EC:2.1.1.99] +synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99] +synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" RELATED [EC:2.1.1.99] +xref: EC:2.1.1.99 +xref: KEGG_REACTION:R04013 +xref: MetaCyc:2.1.1.99-RXN +xref: RHEA:11336 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030769 +name: macrocin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17269] +synonym: "macrocin methyltransferase activity" RELATED [EC:2.1.1.101] +synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" RELATED [EC:2.1.1.101] +synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" RELATED [EC:2.1.1.101] +xref: EC:2.1.1.101 +xref: KEGG_REACTION:R02858 +xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN +xref: RHEA:17269 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030770 +name: demethylmacrocin O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17573] +synonym: "demethylmacrocin methyltransferase activity" RELATED [EC:2.1.1.102] +synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" RELATED [EC:2.1.1.102] +xref: EC:2.1.1.102 +xref: KEGG_REACTION:R02859 +xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN +xref: RHEA:17573 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030771 +name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17405] +synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] +synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" RELATED [EC:2.1.1.105] +synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" RELATED [EC:2.1.1.105] +xref: EC:2.1.1.105 +xref: KEGG_REACTION:R04421 +xref: MetaCyc:2.1.1.105-RXN +xref: RHEA:17405 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030772 +name: tryptophan 2-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17321] +synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" RELATED [EC:2.1.1.106] +synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" RELATED [EC:2.1.1.106] +synonym: "tryptophan 2-methyltransferase activity" RELATED [EC:2.1.1.106] +xref: EC:2.1.1.106 +xref: KEGG_REACTION:R08547 +xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN +xref: RHEA:17321 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030773 +name: 6-hydroxymellein O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15201] +synonym: "6-hydroxymellein methyltransferase activity" RELATED [EC:2.1.1.108] +synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" RELATED [EC:2.1.1.108] +xref: EC:2.1.1.108 +xref: KEGG_REACTION:R03934 +xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN +xref: RHEA:15201 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030774 +name: anthranilate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12180] +synonym: "anthranilic acid N-methyltransferase activity" RELATED [EC:2.1.1.111] +synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" RELATED [EC:2.1.1.111] +xref: EC:2.1.1.111 +xref: KEGG_REACTION:R00984 +xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN +xref: RHEA:12180 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030775 +name: glucuronoxylan 4-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] +synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" RELATED [EC:2.1.1.112] +xref: EC:2.1.1.112 +xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN +xref: RHEA:20413 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030776 +name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] +synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" RELATED [EC:2.1.1.115] +synonym: "norreticuline N-methyltransferase activity" RELATED [EC:2.1.1.115] +synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" RELATED [EC:2.1.1.115] +xref: EC:2.1.1.115 +xref: MetaCyc:2.1.1.115-RXN +xref: RHEA:13005 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030777 +name: (S)-scoulerine 9-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23808] +synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" RELATED [EC:2.1.1.117] +synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" RELATED [EC:2.1.1.117] +xref: EC:2.1.1.117 +xref: KEGG_REACTION:R03835 +xref: MetaCyc:2.1.1.117-RXN +xref: RHEA:23808 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030778 +name: columbamine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15373] +synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" RELATED [EC:2.1.1.118] +xref: EC:2.1.1.118 +xref: KEGG_REACTION:R03721 +xref: MetaCyc:2.1.1.118-RXN +xref: RHEA:15373 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030779 +name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18541] +synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" RELATED [EC:2.1.1.119] +xref: EC:2.1.1.119 +xref: KEGG_REACTION:R04707 +xref: MetaCyc:2.1.1.119-RXN +xref: RHEA:18541 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030780 +name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21092] +synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" RELATED [EC:2.1.1.120] +xref: EC:2.1.1.120 +xref: KEGG_REACTION:R04705 +xref: MetaCyc:2.1.1.120-RXN +xref: RHEA:21092 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030781 +name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] +synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" RELATED [EC:2.1.1.121] +xref: EC:2.1.1.121 +xref: MetaCyc:2.1.1.121-RXN +xref: RHEA:11892 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030782 +name: (S)-tetrahydroprotoberberine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] +synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" RELATED [EC:2.1.1.122] +synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" RELATED [EC:2.1.1.122] +xref: EC:2.1.1.122 +xref: MetaCyc:2.1.1.122-RXN +xref: RHEA:12805 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030783 +name: [cytochrome c]-methionine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] +synonym: "cytochrome c-methionine S-methyltransferase activity" RELATED [EC:2.1.1.123] +synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" RELATED [EC:2.1.1.123] +xref: EC:2.1.1.123 +xref: MetaCyc:2.1.1.123-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030784 +name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] +synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" RELATED [EC:2.1.1.116] +xref: EC:2.1.1.116 +xref: MetaCyc:2.1.1.116-RXN +xref: RHEA:17789 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030785 +name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] +synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" RELATED [EC:2.1.1.127] +synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" RELATED [EC:2.1.1.127] +synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" RELATED [EC:2.1.1.127] +synonym: "RuBisCO LSMT activity" RELATED [EC:2.1.1.127] +synonym: "RuBisCO methyltransferase activity" RELATED [EC:2.1.1.127] +synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" RELATED [EC:2.1.1.127] +synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" RELATED [EC:2.1.1.127] +xref: EC:2.1.1.127 +xref: MetaCyc:2.1.1.127-RXN +xref: RHEA:50996 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030786 +name: (RS)-norcoclaurine 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] +synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" RELATED [EC:2.1.1.128] +xref: EC:2.1.1.128 +xref: MetaCyc:2.1.1.128-RXN +xref: RHEA:19941 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030787 +name: inositol 4-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23248] +synonym: "myo-inositol 4-O-methyltransferase activity" RELATED [EC:2.1.1.129] +synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] +synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" RELATED [EC:2.1.1.129] +synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" RELATED [EC:2.1.1.129] +xref: EC:2.1.1.129 +xref: KEGG_REACTION:R01190 +xref: MetaCyc:2.1.1.129-RXN +xref: RHEA:23248 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030788 +name: precorrin-2 C20-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16841] +synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" RELATED [EC:2.1.1.130] +synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" RELATED [EC:2.1.1.130] +xref: EC:2.1.1.130 +xref: KEGG_REACTION:R03948 +xref: MetaCyc:2.1.1.130-RXN +xref: RHEA:16841 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030789 +name: precorrin-3B C17-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] +synonym: "CobJ" RELATED [EC:2.1.1.131] +synonym: "precorrin-3 methylase activity" RELATED [EC:2.1.1.131] +synonym: "precorrin-3 methyltransferase activity" RELATED [EC:2.1.1.131] +synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" RELATED [EC:2.1.1.131] +xref: EC:2.1.1.131 +xref: MetaCyc:2.1.1.131-RXN +xref: RHEA:12761 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030790 +name: chlorophenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] +synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] +synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" RELATED [EC:2.1.1.136] +synonym: "trichlorophenol O-methyltransferase activity" RELATED [EC:2.1.1.136] +xref: EC:2.1.1.136 +xref: MetaCyc:2.1.1.136-RXN +xref: RHEA:18909 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030791 +name: arsenite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] +comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). +synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" RELATED [EC:2.1.1.137] +synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" RELATED [EC:2.1.1.137] +synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" RELATED [EC:2.1.1.137] +xref: EC:2.1.1.137 +xref: MetaCyc:2.1.1.137-RXN +xref: Reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite" +xref: Reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)" +xref: RHEA:15293 +xref: UM-BBD_reactionID:r0805 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030792 +name: methylarsonite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] +comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). +xref: EC:2.1.1.- +xref: MetaCyc:2.1.1.138-RXN +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030793 +name: 3'-demethylstaurosporine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11696] +synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" RELATED [EC:2.1.1.139] +synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" RELATED [EC:2.1.1.139] +synonym: "staurosporine synthase activity" RELATED [EC:2.1.1.139] +xref: EC:2.1.1.139 +xref: KEGG_REACTION:R05757 +xref: MetaCyc:2.1.1.139-RXN +xref: RHEA:11696 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030794 +name: (S)-coclaurine-N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] +synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" RELATED [EC:2.1.1.140] +xref: EC:2.1.1.140 +xref: MetaCyc:2.1.1.140-RXN +xref: RHEA:17409 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030795 +name: methyl jasmonate methylesterase activity +namespace: molecular_function +alt_id: GO:0045546 +alt_id: GO:0102078 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate." [RHEA:13349] +synonym: "jasmonic acid carboxyl methyltransferase activity" RELATED [EC:2.1.1.141] +synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" RELATED [EC:2.1.1.141] +synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] +xref: EC:2.1.1.141 +xref: MetaCyc:RXN-10768 +xref: RHEA:13349 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030796 +name: cycloartenol 24-C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13137] +synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" RELATED [EC:2.1.1.142] +synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] +xref: EC:2.1.1.142 +xref: KEGG_REACTION:R05760 +xref: MetaCyc:2.1.1.142-RXN +xref: RHEA:13137 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030797 +name: 24-methylenesterol C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21044] +synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" RELATED [EC:2.1.1.143] +synonym: "24-methylenelophenol C-241-methyltransferase activity" RELATED [EC:2.1.1.143] +synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" RELATED [EC:2.1.1.143] +synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] +synonym: "SMT2" RELATED [EC:2.1.1.143] +xref: EC:2.1.1.143 +xref: KEGG_REACTION:R05776 +xref: MetaCyc:2.1.1.143-RXN +xref: RHEA:21044 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030798 +name: trans-aconitate 2-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14969] +synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" RELATED [EC:2.1.1.144] +xref: EC:2.1.1.144 +xref: KEGG_REACTION:R05763 +xref: MetaCyc:RXN0-2441 +xref: RHEA:14969 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0030799 +name: obsolete regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of cyclic nucleotide metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030800 +name: obsolete negative regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "down regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "downregulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "inhibition of cyclic nucleotide metabolic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030801 +name: obsolete positive regulation of cyclic nucleotide metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cyclic nucleotide metabolic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide metabolism" EXACT [] +synonym: "stimulation of cyclic nucleotide metabolic process" NARROW [] +synonym: "up regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT [] +synonym: "upregulation of cyclic nucleotide metabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030802 +name: obsolete regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "regulation of cyclic nucleotide formation" EXACT [] +synonym: "regulation of cyclic nucleotide synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030803 +name: obsolete negative regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of cyclic nucleotide formation" EXACT [] +synonym: "negative regulation of cyclic nucleotide synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030804 +name: obsolete positive regulation of cyclic nucleotide biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide anabolism" EXACT [] +synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of cyclic nucleotide formation" EXACT [] +synonym: "positive regulation of cyclic nucleotide synthesis" EXACT [] +synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW [] +synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030805 +name: regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +synonym: "regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "regulation of cyclic nucleotide degradation" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process + +[Term] +id: GO:0030806 +name: obsolete negative regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "down regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "downregulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "inhibition of cyclic nucleotide catabolic process" NARROW [] +synonym: "negative regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "negative regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "negative regulation of cyclic nucleotide degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030807 +name: obsolete positive regulation of cyclic nucleotide catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cyclic nucleotide catabolic process" NARROW [] +synonym: "positive regulation of cyclic nucleotide breakdown" EXACT [] +synonym: "positive regulation of cyclic nucleotide catabolism" EXACT [] +synonym: "positive regulation of cyclic nucleotide degradation" EXACT [] +synonym: "stimulation of cyclic nucleotide catabolic process" NARROW [] +synonym: "up regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT [] +synonym: "upregulation of cyclic nucleotide catabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030808 +name: regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +synonym: "regulation of nucleotide anabolism" EXACT [] +synonym: "regulation of nucleotide biosynthesis" EXACT [] +synonym: "regulation of nucleotide formation" EXACT [] +synonym: "regulation of nucleotide synthesis" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030809 +name: negative regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +synonym: "down regulation of nucleotide biosynthetic process" EXACT [] +synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "downregulation of nucleotide biosynthetic process" EXACT [] +synonym: "inhibition of nucleotide biosynthetic process" NARROW [] +synonym: "negative regulation of nucleotide anabolism" EXACT [] +synonym: "negative regulation of nucleotide biosynthesis" EXACT [] +synonym: "negative regulation of nucleotide formation" EXACT [] +synonym: "negative regulation of nucleotide synthesis" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030810 +name: positive regulation of nucleotide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] +synonym: "activation of nucleotide biosynthetic process" NARROW [] +synonym: "positive regulation of nucleotide anabolism" EXACT [] +synonym: "positive regulation of nucleotide biosynthesis" EXACT [] +synonym: "positive regulation of nucleotide formation" EXACT [] +synonym: "positive regulation of nucleotide synthesis" EXACT [] +synonym: "stimulation of nucleotide biosynthetic process" NARROW [] +synonym: "up regulation of nucleotide biosynthetic process" EXACT [] +synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] +synonym: "upregulation of nucleotide biosynthetic process" EXACT [] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0030811 +name: regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +synonym: "regulation of nucleotide breakdown" EXACT [] +synonym: "regulation of nucleotide catabolism" EXACT [] +synonym: "regulation of nucleotide degradation" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030812 +name: negative regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +synonym: "down regulation of nucleotide catabolic process" EXACT [] +synonym: "down-regulation of nucleotide catabolic process" EXACT [] +synonym: "downregulation of nucleotide catabolic process" EXACT [] +synonym: "inhibition of nucleotide catabolic process" NARROW [] +synonym: "negative regulation of nucleotide breakdown" EXACT [] +synonym: "negative regulation of nucleotide catabolism" EXACT [] +synonym: "negative regulation of nucleotide degradation" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030813 +name: positive regulation of nucleotide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] +synonym: "activation of nucleotide catabolic process" NARROW [] +synonym: "positive regulation of nucleotide breakdown" EXACT [] +synonym: "positive regulation of nucleotide catabolism" EXACT [] +synonym: "positive regulation of nucleotide degradation" EXACT [] +synonym: "stimulation of nucleotide catabolic process" NARROW [] +synonym: "up regulation of nucleotide catabolic process" EXACT [] +synonym: "up-regulation of nucleotide catabolic process" EXACT [] +synonym: "upregulation of nucleotide catabolic process" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +relationship: positively_regulates GO:0009166 ! nucleotide catabolic process + +[Term] +id: GO:0030814 +name: obsolete regulation of cAMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "regulation of cAMP metabolism" EXACT [] +synonym: "regulation of cyclic AMP metabolic process" EXACT [] +synonym: "regulation of cyclic AMP metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030815 +name: obsolete negative regulation of cAMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "down regulation of cAMP metabolic process" EXACT [] +synonym: "down-regulation of cAMP metabolic process" EXACT [] +synonym: "downregulation of cAMP metabolic process" EXACT [] +synonym: "inhibition of cAMP metabolic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "negative regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "negative regulation of cAMP metabolism" EXACT [] +synonym: "negative regulation of cyclic AMP metabolic process" EXACT [] +synonym: "negative regulation of cyclic AMP metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030816 +name: obsolete positive regulation of cAMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cAMP metabolic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT [] +synonym: "positive regulation of 3',5' cAMP metabolism" EXACT [] +synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "positive regulation of cAMP metabolism" EXACT [] +synonym: "positive regulation of cyclic AMP metabolic process" EXACT [] +synonym: "positive regulation of cyclic AMP metabolism" EXACT [] +synonym: "stimulation of cAMP metabolic process" NARROW [] +synonym: "up regulation of cAMP metabolic process" EXACT [] +synonym: "up-regulation of cAMP metabolic process" EXACT [] +synonym: "upregulation of cAMP metabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030817 +name: obsolete regulation of cAMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "regulation of cAMP anabolism" EXACT [] +synonym: "regulation of cAMP biosynthesis" EXACT [] +synonym: "regulation of cAMP formation" EXACT [] +synonym: "regulation of cAMP synthesis" EXACT [] +synonym: "regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "regulation of cyclic AMP biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030818 +name: obsolete negative regulation of cAMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that the term represents a molecular function. +synonym: "down regulation of cAMP biosynthetic process" EXACT [] +synonym: "down-regulation of cAMP biosynthetic process" EXACT [] +synonym: "downregulation of cAMP biosynthetic process" EXACT [] +synonym: "inhibition of cAMP biosynthetic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "negative regulation of cAMP anabolism" EXACT [] +synonym: "negative regulation of cAMP biosynthesis" EXACT [] +synonym: "negative regulation of cAMP formation" EXACT [] +synonym: "negative regulation of cAMP synthesis" EXACT [] +synonym: "negative regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030819 +name: obsolete positive regulation of cAMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +synonym: "activation of cAMP biosynthetic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT [] +synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT [] +synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] +synonym: "positive regulation of cAMP anabolism" EXACT [] +synonym: "positive regulation of cAMP biosynthesis" EXACT [] +synonym: "positive regulation of cAMP formation" EXACT [] +synonym: "positive regulation of cAMP synthesis" EXACT [] +synonym: "positive regulation of cyclic AMP biosynthesis" EXACT [] +synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT [] +synonym: "stimulation of cAMP biosynthetic process" NARROW [] +synonym: "up regulation of cAMP biosynthetic process" EXACT [] +synonym: "up-regulation of cAMP biosynthetic process" EXACT [] +synonym: "upregulation of cAMP biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030820 +name: obsolete regulation of cAMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "regulation of cAMP breakdown" EXACT [] +synonym: "regulation of cAMP catabolism" EXACT [] +synonym: "regulation of cAMP degradation" EXACT [] +synonym: "regulation of cyclic AMP catabolic process" EXACT [] +synonym: "regulation of cyclic AMP catabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030821 +name: obsolete negative regulation of cAMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "down regulation of cAMP catabolic process" EXACT [] +synonym: "down-regulation of cAMP catabolic process" EXACT [] +synonym: "downregulation of cAMP catabolic process" EXACT [] +synonym: "inhibition of cAMP catabolic process" NARROW [] +synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "negative regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "negative regulation of cAMP breakdown" EXACT [] +synonym: "negative regulation of cAMP catabolism" EXACT [] +synonym: "negative regulation of cAMP degradation" EXACT [] +synonym: "negative regulation of cyclic AMP catabolic process" EXACT [] +synonym: "negative regulation of cyclic AMP catabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030822 +name: obsolete positive regulation of cAMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cAMP catabolic process" NARROW [] +synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT [] +synonym: "positive regulation of 3',5' cAMP catabolism" EXACT [] +synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT [] +synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] +synonym: "positive regulation of cAMP breakdown" EXACT [] +synonym: "positive regulation of cAMP catabolism" EXACT [] +synonym: "positive regulation of cAMP degradation" EXACT [] +synonym: "positive regulation of cyclic AMP catabolic process" EXACT [] +synonym: "positive regulation of cyclic AMP catabolism" EXACT [] +synonym: "stimulation of cAMP catabolic process" NARROW [] +synonym: "up regulation of cAMP catabolic process" EXACT [] +synonym: "up-regulation of cAMP catabolic process" EXACT [] +synonym: "upregulation of cAMP catabolic process" EXACT [] +is_obsolete: true +consider: GO:0071878 + +[Term] +id: GO:0030823 +name: obsolete regulation of cGMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of cGMP metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030824 +name: obsolete negative regulation of cGMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. +synonym: "down regulation of cGMP metabolic process" EXACT [] +synonym: "down-regulation of cGMP metabolic process" EXACT [] +synonym: "downregulation of cGMP metabolic process" EXACT [] +synonym: "inhibition of cGMP metabolic process" NARROW [] +synonym: "negative regulation of cGMP metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030825 +name: obsolete positive regulation of cGMP metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cGMP metabolic process" NARROW [] +synonym: "positive regulation of cGMP metabolism" EXACT [] +synonym: "stimulation of cGMP metabolic process" NARROW [] +synonym: "up regulation of cGMP metabolic process" EXACT [] +synonym: "up-regulation of cGMP metabolic process" EXACT [] +synonym: "upregulation of cGMP metabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030826 +name: obsolete regulation of cGMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of cGMP anabolism" EXACT [] +synonym: "regulation of cGMP biosynthesis" EXACT [] +synonym: "regulation of cGMP formation" EXACT [] +synonym: "regulation of cGMP synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030827 +name: obsolete negative regulation of cGMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. +synonym: "down regulation of cGMP biosynthetic process" EXACT [] +synonym: "down-regulation of cGMP biosynthetic process" EXACT [] +synonym: "downregulation of cGMP biosynthetic process" EXACT [] +synonym: "inhibition of cGMP biosynthetic process" NARROW [] +synonym: "negative regulation of cGMP anabolism" EXACT [] +synonym: "negative regulation of cGMP biosynthesis" EXACT [] +synonym: "negative regulation of cGMP formation" EXACT [] +synonym: "negative regulation of cGMP synthesis" EXACT [] +is_obsolete: true +consider: GO:0030251 + +[Term] +id: GO:0030828 +name: obsolete positive regulation of cGMP biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cGMP biosynthetic process" NARROW [] +synonym: "positive regulation of cGMP anabolism" EXACT [] +synonym: "positive regulation of cGMP biosynthesis" EXACT [] +synonym: "positive regulation of cGMP formation" EXACT [] +synonym: "positive regulation of cGMP synthesis" EXACT [] +synonym: "stimulation of cGMP biosynthetic process" NARROW [] +synonym: "up regulation of cGMP biosynthetic process" EXACT [] +synonym: "up-regulation of cGMP biosynthetic process" EXACT [] +synonym: "upregulation of cGMP biosynthetic process" EXACT [] +is_obsolete: true +consider: GO:0004383 + +[Term] +id: GO:0030829 +name: obsolete regulation of cGMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. +synonym: "regulation of cGMP breakdown" EXACT [] +synonym: "regulation of cGMP catabolism" EXACT [] +synonym: "regulation of cGMP degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030830 +name: obsolete negative regulation of cGMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. +synonym: "down regulation of cGMP catabolic process" EXACT [] +synonym: "down-regulation of cGMP catabolic process" EXACT [] +synonym: "downregulation of cGMP catabolic process" EXACT [] +synonym: "inhibition of cGMP catabolic process" NARROW [] +synonym: "negative regulation of cGMP breakdown" EXACT [] +synonym: "negative regulation of cGMP catabolism" EXACT [] +synonym: "negative regulation of cGMP degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030831 +name: obsolete positive regulation of cGMP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] +comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. +synonym: "activation of cGMP catabolic process" NARROW [] +synonym: "positive regulation of cGMP breakdown" EXACT [] +synonym: "positive regulation of cGMP catabolism" EXACT [] +synonym: "positive regulation of cGMP degradation" EXACT [] +synonym: "stimulation of cGMP catabolic process" NARROW [] +synonym: "up regulation of cGMP catabolic process" EXACT [] +synonym: "up-regulation of cGMP catabolic process" EXACT [] +synonym: "upregulation of cGMP catabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0030832 +name: regulation of actin filament length +namespace: biological_process +def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0032535 ! regulation of cellular component size +is_a: GO:0032956 ! regulation of actin cytoskeleton organization + +[Term] +id: GO:0030833 +name: regulation of actin filament polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] +synonym: "regulation of actin polymerization" EXACT [] +is_a: GO:0008064 ! regulation of actin polymerization or depolymerization +is_a: GO:0032271 ! regulation of protein polymerization +relationship: regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030834 +name: regulation of actin filament depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] +synonym: "regulation of actin depolymerization" EXACT [] +is_a: GO:0008064 ! regulation of actin polymerization or depolymerization +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030835 +name: negative regulation of actin filament depolymerization +namespace: biological_process +alt_id: GO:0030044 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] +comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). +synonym: "actin filament stabilization" EXACT [] +synonym: "down regulation of actin filament depolymerization" EXACT [] +synonym: "down-regulation of actin filament depolymerization" EXACT [] +synonym: "downregulation of actin filament depolymerization" EXACT [] +synonym: "inhibition of actin filament depolymerization" NARROW [] +synonym: "negative regulation of actin depolymerization" EXACT [] +synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] +is_a: GO:0030834 ! regulation of actin filament depolymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1901880 ! negative regulation of protein depolymerization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030836 +name: positive regulation of actin filament depolymerization +namespace: biological_process +alt_id: GO:0030045 +def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah] +comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). +synonym: "actin filament destabilization" EXACT [] +synonym: "activation of actin filament depolymerization" NARROW [] +synonym: "positive regulation of actin depolymerization" EXACT [] +synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of actin filament depolymerization" NARROW [] +synonym: "up regulation of actin filament depolymerization" EXACT [] +synonym: "up-regulation of actin filament depolymerization" EXACT [] +synonym: "upregulation of actin filament depolymerization" EXACT [] +is_a: GO:0030834 ! regulation of actin filament depolymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1901881 ! positive regulation of protein depolymerization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0030042 ! actin filament depolymerization + +[Term] +id: GO:0030837 +name: negative regulation of actin filament polymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] +comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). +synonym: "down regulation of actin filament polymerization" EXACT [] +synonym: "down-regulation of actin filament polymerization" EXACT [] +synonym: "downregulation of actin filament polymerization" EXACT [] +synonym: "inhibition of actin filament polymerization" NARROW [] +synonym: "negative regulation of actin polymerization" EXACT [] +synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] +is_a: GO:0030833 ! regulation of actin filament polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030838 +name: positive regulation of actin filament polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah] +comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). +synonym: "activation of actin filament polymerization" NARROW [] +synonym: "positive regulation of actin polymerization" EXACT [] +synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of actin filament polymerization" NARROW [] +synonym: "up regulation of actin filament polymerization" EXACT [] +synonym: "up-regulation of actin filament polymerization" EXACT [] +synonym: "upregulation of actin filament polymerization" EXACT [] +is_a: GO:0030833 ! regulation of actin filament polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0030041 ! actin filament polymerization + +[Term] +id: GO:0030839 +name: regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah] +is_a: GO:0032271 ! regulation of protein polymerization +is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization +relationship: regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030840 +name: negative regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] +comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). +synonym: "down regulation of intermediate filament polymerization" EXACT [] +synonym: "down-regulation of intermediate filament polymerization" EXACT [] +synonym: "downregulation of intermediate filament polymerization" EXACT [] +synonym: "inhibition of intermediate filament polymerization" NARROW [] +synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +is_a: GO:0030839 ! regulation of intermediate filament polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030841 +name: positive regulation of intermediate filament polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] +comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). +synonym: "activation of intermediate filament polymerization" NARROW [] +synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of intermediate filament polymerization" NARROW [] +synonym: "up regulation of intermediate filament polymerization" EXACT [] +synonym: "up-regulation of intermediate filament polymerization" EXACT [] +synonym: "upregulation of intermediate filament polymerization" EXACT [] +is_a: GO:0030839 ! regulation of intermediate filament polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0045107 ! intermediate filament polymerization + +[Term] +id: GO:0030842 +name: regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah] +is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030843 +name: negative regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] +comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). +synonym: "down regulation of intermediate filament depolymerization" EXACT [] +synonym: "down-regulation of intermediate filament depolymerization" EXACT [] +synonym: "downregulation of intermediate filament depolymerization" EXACT [] +synonym: "inhibition of intermediate filament depolymerization" NARROW [] +synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +is_a: GO:0030842 ! regulation of intermediate filament depolymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1901880 ! negative regulation of protein depolymerization +relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030844 +name: positive regulation of intermediate filament depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] +comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). +synonym: "activation of intermediate filament depolymerization" NARROW [] +synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] +synonym: "stimulation of intermediate filament depolymerization" NARROW [] +synonym: "up regulation of intermediate filament depolymerization" EXACT [] +synonym: "up-regulation of intermediate filament depolymerization" EXACT [] +synonym: "upregulation of intermediate filament depolymerization" EXACT [] +is_a: GO:0030842 ! regulation of intermediate filament depolymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1901881 ! positive regulation of protein depolymerization +relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization + +[Term] +id: GO:0030845 +name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway +namespace: biological_process +def: "A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098] +comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition. +synonym: "G-protein-coupled inhibitory pathway of phospholipase C" EXACT [PMID:8280098] +synonym: "GPCR signaling pathway coupled to inhibition of phospholipase C activity" EXACT [GOC:signaling] +synonym: "GPCR signaling pathway via inhibition of PLC" EXACT [GOC:signaling] +synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" NARROW [GOC:mah] +synonym: "phospholipase C inhibition" RELATED [GOC:dph, GOC:tb] +synonym: "phospholipase C-inhibiting G-protein coupled receptor signaling pathway" EXACT [] +synonym: "PLC-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0030846 +name: termination of RNA polymerase II transcription, poly(A)-coupled +namespace: biological_process +def: "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429] +synonym: "termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] +synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED [] +synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [] +is_a: GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:0030847 +name: termination of RNA polymerase II transcription, exosome-dependent +namespace: biological_process +def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429] +synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT [] +synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT [] +synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT [] +is_a: GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:0030848 +name: threo-3-hydroxyaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12424] +synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] +synonym: "L-threo-3-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.16] +synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" RELATED [EC:4.3.1.16] +synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.16] +synonym: "threo-3-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.16] +xref: EC:4.3.1.16 +xref: KEGG_REACTION:R05758 +xref: MetaCyc:4.3.1.16-RXN +xref: RHEA:12424 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0030849 +name: autosome +namespace: cellular_component +def: "Any chromosome other than a sex chromosome." [GOC:mah] +comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. +xref: Wikipedia:Autosome +is_a: GO:0005694 ! chromosome + +[Term] +id: GO:0030850 +name: prostate gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] +synonym: "prostate development" EXACT [] +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0048732 ! gland development +relationship: part_of GO:0001655 ! urogenital system development + +[Term] +id: GO:0030851 +name: granulocyte differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] +synonym: "granulocyte cell differentiation" EXACT [] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0030852 +name: regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030853 +name: negative regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +synonym: "down regulation of granulocyte differentiation" EXACT [] +synonym: "down-regulation of granulocyte differentiation" EXACT [] +synonym: "downregulation of granulocyte differentiation" EXACT [] +synonym: "inhibition of granulocyte differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: negatively_regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030854 +name: positive regulation of granulocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] +synonym: "activation of granulocyte differentiation" NARROW [] +synonym: "stimulation of granulocyte differentiation" NARROW [] +synonym: "up regulation of granulocyte differentiation" EXACT [] +synonym: "up-regulation of granulocyte differentiation" EXACT [] +synonym: "upregulation of granulocyte differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: positively_regulates GO:0030851 ! granulocyte differentiation + +[Term] +id: GO:0030855 +name: epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0060429 ! epithelium development + +[Term] +id: GO:0030856 +name: regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030857 +name: negative regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +synonym: "down regulation of epithelial cell differentiation" EXACT [] +synonym: "down-regulation of epithelial cell differentiation" EXACT [] +synonym: "downregulation of epithelial cell differentiation" EXACT [] +synonym: "inhibition of epithelial cell differentiation" NARROW [] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030858 +name: positive regulation of epithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] +synonym: "activation of epithelial cell differentiation" NARROW [] +synonym: "stimulation of epithelial cell differentiation" NARROW [] +synonym: "up regulation of epithelial cell differentiation" EXACT [] +synonym: "up-regulation of epithelial cell differentiation" EXACT [] +synonym: "upregulation of epithelial cell differentiation" EXACT [] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0030859 +name: polarized epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium + +[Term] +id: GO:0030860 +name: regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030861 +name: negative regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] +synonym: "down regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "down-regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "downregulation of polarized epithelial cell differentiation" EXACT [] +synonym: "inhibition of polarized epithelial cell differentiation" NARROW [] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation +relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030862 +name: positive regulation of polarized epithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah] +synonym: "activation of polarized epithelial cell differentiation" NARROW [] +synonym: "stimulation of polarized epithelial cell differentiation" NARROW [] +synonym: "up regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "up-regulation of polarized epithelial cell differentiation" EXACT [] +synonym: "upregulation of polarized epithelial cell differentiation" EXACT [] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation +relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation + +[Term] +id: GO:0030863 +name: cortical cytoskeleton +namespace: cellular_component +def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0005856 ! cytoskeleton +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0030864 +name: cortical actin cytoskeleton +namespace: cellular_component +def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0030863 ! cortical cytoskeleton +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0030865 +name: cortical cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] +synonym: "cortical cytoskeleton organisation" EXACT [] +synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0030866 +name: cortical actin cytoskeleton organization +namespace: biological_process +alt_id: GO:0033109 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf] +synonym: "actin cortex stabilization" EXACT [] +synonym: "cortical actin cytoskeleton organisation" EXACT [] +synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] +synonym: "cortical actin cytoskeleton stabilization" EXACT [] +synonym: "cortical resistance" RELATED [] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0030865 ! cortical cytoskeleton organization + +[Term] +id: GO:0030867 +name: rough endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] +synonym: "RER membrane" EXACT [NIF_Subcellular:sao3089754107] +synonym: "rough ER membrane" EXACT [] +xref: NIF_Subcellular:sao3089754107 +is_a: GO:0005789 ! endoplasmic reticulum membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005791 ! rough endoplasmic reticulum + +[Term] +id: GO:0030868 +name: smooth endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] +synonym: "SER membrane" EXACT [] +synonym: "smooth ER membrane" EXACT [] +xref: NIF_Subcellular:sao1596955044 +is_a: GO:0005789 ! endoplasmic reticulum membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum + +[Term] +id: GO:0030869 +name: RENT complex +namespace: cellular_component +def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] +is_a: GO:0005677 ! chromatin silencing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0030870 +name: Mre11 complex +namespace: cellular_component +def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] +synonym: "MRN complex" EXACT [] +synonym: "MRX complex" EXACT [] +synonym: "Rad50 complex" EXACT [] +synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767] +synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] +synonym: "RMX complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0030874 +name: nucleolar chromatin +namespace: cellular_component +def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0030875 +name: rDNA protrusion +namespace: cellular_component +def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] +comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. +synonym: "ribosomal DNA protrusion" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030874 ! nucleolar chromatin + +[Term] +id: GO:0030876 +name: interleukin-20 receptor complex +namespace: cellular_component +def: "A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits." [PMID:12351624] +synonym: "IL-20 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0030877 +name: beta-catenin destruction complex +namespace: cellular_component +alt_id: GO:0034742 +alt_id: GO:0034747 +def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "23S APC complex" NARROW [] +synonym: "APC-Axin-1-beta-catenin complex" EXACT [] +synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT [] +synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650] +synonym: "beta-catenin degradation complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0030878 +name: thyroid gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0030879 +name: mammary gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] +synonym: "mammogenesis" NARROW [GOC:dph] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0030880 +name: RNA polymerase complex +namespace: cellular_component +def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] +subset: goslim_pir +synonym: "multisubunit RNA polymerase" EXACT [] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0030881 +name: beta-2-microglobulin binding +namespace: molecular_function +def: "Binding to beta-2-microglobulin." [GOC:mah] +subset: goslim_chembl +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030882 +name: lipid antigen binding +namespace: molecular_function +def: "Binding to a lipid antigen." [PMID:14500461] +is_a: GO:0003823 ! antigen binding +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0030883 +name: endogenous lipid antigen binding +namespace: molecular_function +def: "Binding to an endogenous cellular lipid antigen." [PMID:14500461] +is_a: GO:0030882 ! lipid antigen binding + +[Term] +id: GO:0030884 +name: exogenous lipid antigen binding +namespace: molecular_function +def: "Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] +is_a: GO:0030882 ! lipid antigen binding + +[Term] +id: GO:0030885 +name: regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030886 +name: negative regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] +synonym: "down regulation of myeloid dendritic cell activation" EXACT [] +synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] +synonym: "downregulation of myeloid dendritic cell activation" EXACT [] +synonym: "inhibition of myeloid dendritic cell activation" NARROW [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0030885 ! regulation of myeloid dendritic cell activation +relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030887 +name: positive regulation of myeloid dendritic cell activation +namespace: biological_process +def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] +synonym: "activation of myeloid dendritic cell activation" NARROW [] +synonym: "stimulation of myeloid dendritic cell activation" NARROW [] +synonym: "up regulation of myeloid dendritic cell activation" EXACT [] +synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] +synonym: "upregulation of myeloid dendritic cell activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0030885 ! regulation of myeloid dendritic cell activation +relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation + +[Term] +id: GO:0030888 +name: regulation of B cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] +synonym: "regulation of B lymphocyte proliferation" EXACT [] +synonym: "regulation of B-cell proliferation" EXACT [] +synonym: "regulation of B-lymphocyte proliferation" EXACT [] +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0050864 ! regulation of B cell activation +relationship: regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030889 +name: negative regulation of B cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] +synonym: "down regulation of B cell proliferation" EXACT [] +synonym: "down-regulation of B cell proliferation" EXACT [] +synonym: "downregulation of B cell proliferation" EXACT [] +synonym: "inhibition of B cell proliferation" NARROW [] +synonym: "negative regulation of B lymphocyte proliferation" EXACT [] +synonym: "negative regulation of B-cell proliferation" EXACT [] +synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] +is_a: GO:0030888 ! regulation of B cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +is_a: GO:0050869 ! negative regulation of B cell activation +relationship: negatively_regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030890 +name: positive regulation of B cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] +synonym: "activation of B cell proliferation" NARROW [] +synonym: "positive regulation of B lymphocyte proliferation" EXACT [] +synonym: "positive regulation of B-cell proliferation" EXACT [] +synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] +synonym: "stimulation of B cell proliferation" NARROW [] +synonym: "up regulation of B cell proliferation" EXACT [] +synonym: "up-regulation of B cell proliferation" EXACT [] +synonym: "upregulation of B cell proliferation" EXACT [] +is_a: GO:0030888 ! regulation of B cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +is_a: GO:0050871 ! positive regulation of B cell activation +relationship: positively_regulates GO:0042100 ! B cell proliferation + +[Term] +id: GO:0030891 +name: VCB complex +namespace: cellular_component +def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] +synonym: "pVHL-elongin C-elongin B complex" EXACT [] +synonym: "VHL complex" EXACT [] +synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex + +[Term] +id: GO:0030892 +name: mitotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] +is_a: GO:0008278 ! cohesin complex + +[Term] +id: GO:0030893 +name: meiotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] +is_a: GO:0008278 ! cohesin complex + +[Term] +id: GO:0030894 +name: replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] +subset: goslim_pir +synonym: "DNA synthesome complex" RELATED [CORUM:1001] +synonym: "RC complex" RELATED [CORUM:309, PMID:12006500] +synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500] +xref: Wikipedia:Replisome +is_a: GO:0032993 ! protein-DNA complex +relationship: part_of GO:0005657 ! replication fork + +[Term] +id: GO:0030895 +name: apolipoprotein B mRNA editing enzyme complex +namespace: cellular_component +def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] +synonym: "apoB mRNA editing enzyme complex" EXACT [] +synonym: "APOBEC" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0030896 +name: checkpoint clamp complex +namespace: cellular_component +def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] +comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. +synonym: "CCC" EXACT [] +synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0030897 +name: HOPS complex +namespace: cellular_component +def: "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0099023 ! vesicle tethering complex + +[Term] +id: GO:0030899 +name: calcium-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah] +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0030900 +name: forebrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] +synonym: "prosencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030901 +name: midbrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain] +synonym: "mesencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030902 +name: hindbrain development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain] +synonym: "rhombencephalon development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0030903 +name: notochord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0030904 +name: retromer complex +namespace: cellular_component +def: "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157] +subset: goslim_pir +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0030905 +name: retromer, tubulation complex +namespace: cellular_component +def: "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157] +synonym: "heterodimeric membrane-deforming retromer subcomplex" EXACT [GOC:bf, GOC:PARL, PMID:22193161] +synonym: "retromer complex, outer shell" EXACT [] +synonym: "SNX-BAR dimer" EXACT [PMID:26220253] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0030904 ! retromer complex + +[Term] +id: GO:0030906 +name: retromer, cargo-selective complex +namespace: cellular_component +def: "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157] +synonym: "cargo-selective retromer subcomplex" EXACT [PMID:19531583, PMID:20923837] +synonym: "retromer complex, inner shell" EXACT [] +synonym: "retromer CSC" EXACT [GOC:bf, GOC:PARL] +synonym: "retromer, cargo recognition complex" EXACT [PMID:26220253] +synonym: "retromer, CRC" EXACT [GOC:bf, GOC:PARL, PMID:26220253] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0030904 ! retromer complex + +[Term] +id: GO:0030907 +name: MBF transcription complex +namespace: cellular_component +def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385] +synonym: "DSC1 transcription factor complex" EXACT [] +synonym: "MBF" EXACT [] +synonym: "Mlu1-box binding factor" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0030908 +name: protein splicing +namespace: biological_process +def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah] +xref: Wikipedia:Protein_splicing +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0030909 +name: non-intein-mediated protein splicing +namespace: biological_process +def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah] +is_a: GO:0030908 ! protein splicing + +[Term] +id: GO:0030910 +name: olfactory placode formation +namespace: biological_process +def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0043584 ! nose development +relationship: part_of GO:0071699 ! olfactory placode morphogenesis + +[Term] +id: GO:0030911 +name: TPR domain binding +namespace: molecular_function +def: "Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] +synonym: "tetratricopeptide repeat domain binding" EXACT [GOC:sl] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0030912 +name: response to deep water +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah] +comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0030913 +name: paranodal junction assembly +namespace: biological_process +def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942] +synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321] +synonym: "paranodal junction biosynthesis" EXACT [] +synonym: "paranodal junction formation" EXACT [] +is_a: GO:0007043 ! cell-cell junction assembly +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +relationship: part_of GO:0032288 ! myelin assembly + +[Term] +id: GO:0030915 +name: Smc5-Smc6 complex +namespace: cellular_component +def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152] +is_a: GO:0106068 ! SUMO ligase complex +relationship: part_of GO:0000793 ! condensed chromosome + +[Term] +id: GO:0030916 +name: otic vesicle formation +namespace: biological_process +def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] +synonym: "otocyst biosynthesis" EXACT [] +synonym: "otocyst formation" EXACT [] +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0071600 ! otic vesicle morphogenesis + +[Term] +id: GO:0030917 +name: midbrain-hindbrain boundary development +namespace: biological_process +def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] +synonym: "isthmic organizer development" EXACT [] +synonym: "isthmomesencephalic boundary development" EXACT [] +synonym: "isthmus development" EXACT [] +synonym: "MHB development" EXACT [] +synonym: "midbrain-hindbrain orgainizer development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development +relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning + +[Term] +id: GO:0030919 +name: peptidyl-serine O-acetylation +namespace: biological_process +def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364] +xref: RESID:AA0364 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0030920 ! peptidyl-serine acetylation + +[Term] +id: GO:0030920 +name: peptidyl-serine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-serine." [GOC:mah] +is_a: GO:0006473 ! protein acetylation + +[Term] +id: GO:0030921 +name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183] +xref: RESID:AA0183 +is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation + +[Term] +id: GO:0030922 +name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine +namespace: biological_process +def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365] +xref: RESID:AA0365 +is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation + +[Term] +id: GO:0030923 +name: metal incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0030924 +name: manganese incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg] +is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030925 +name: calcium incorporation into metallo-oxygen cluster +namespace: biological_process +def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg] +is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030926 +name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide +namespace: biological_process +def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] +xref: RESID:AA0366 +is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030927 +name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide +namespace: biological_process +def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] +xref: RESID:AA0366 +is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster + +[Term] +id: GO:0030929 +name: ADPG pyrophosphorylase complex +namespace: cellular_component +def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0030930 +name: homotetrameric ADPG pyrophosphorylase complex +namespace: cellular_component +def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0030929 ! ADPG pyrophosphorylase complex + +[Term] +id: GO:0030931 +name: heterotetrameric ADPG pyrophosphorylase complex +namespace: cellular_component +def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0030929 ! ADPG pyrophosphorylase complex + +[Term] +id: GO:0030932 +name: amyloplast ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] +is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0030933 +name: chloroplast ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] +is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0030934 +name: anchoring collagen complex +namespace: cellular_component +def: "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] +synonym: "connecting collagen" EXACT [ISBN:0721639976] +synonym: "linking collagen" EXACT [ISBN:0721639976] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0030935 +name: sheet-forming collagen trimer +namespace: cellular_component +def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet." [PMID:7188361] +synonym: "hexagonal network-forming collagen" EXACT [ISBN:0815316194] +is_a: GO:0098642 ! network-forming collagen trimer +relationship: part_of GO:0098646 ! collagen sheet + +[Term] +id: GO:0030936 +name: transmembrane collagen trimer +namespace: cellular_component +def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] +synonym: "MACIT" EXACT [ISBN:0198599587] +is_a: GO:0005581 ! collagen trimer +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0030937 +name: collagen type XVII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911] +is_a: GO:0030936 ! transmembrane collagen trimer +is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion +is_a: GO:0098733 ! hemidesmosome associated protein complex + +[Term] +id: GO:0030938 +name: collagen type XVIII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976, PMID:21421911] +is_a: GO:0098651 ! basement membrane collagen trimer + +[Term] +id: GO:0030939 +name: obsolete response to long-day photoperiod +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj] +comment: This term was made obsolete because it was wrongly defined. +synonym: "response to long-day photoperiod" EXACT [] +is_obsolete: true +consider: GO:0048571 + +[Term] +id: GO:0030940 +name: obsolete response to short-day photoperiod +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj] +comment: This term was made obsolete because it was wrongly defined. +synonym: "response to short-day photoperiod" EXACT [] +is_obsolete: true +consider: GO:0048572 + +[Term] +id: GO:0030941 +name: chloroplast targeting sequence binding +namespace: molecular_function +def: "Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030942 +name: endoplasmic reticulum signal peptide binding +namespace: molecular_function +def: "Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] +synonym: "ER signal peptide binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030943 +name: mitochondrion targeting sequence binding +namespace: molecular_function +def: "Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] +synonym: "mitochondrial targeting sequence binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0030944 +name: DDEL sequence binding +namespace: molecular_function +def: "Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0030945 +name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate +namespace: molecular_function +def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0030946 +name: protein tyrosine phosphatase activity, metal-dependent +namespace: molecular_function +def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah] +is_a: GO:0004725 ! protein tyrosine phosphatase activity + +[Term] +id: GO:0030947 +name: regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "regulation of VEGF receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030948 +name: negative regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "negative regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of VEGF receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030949 +name: positive regulation of vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] +synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] +synonym: "positive regulation of VEGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of VEGF receptor signalling pathway" EXACT [] +synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway +relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0030950 +name: establishment or maintenance of actin cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity + +[Term] +id: GO:0030951 +name: establishment or maintenance of microtubule cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity + +[Term] +id: GO:0030952 +name: establishment or maintenance of cytoskeleton polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] +synonym: "cytoskeleton polarization" RELATED [] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0030953 +name: astral microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] +synonym: "astral microtubule organisation" EXACT [] +synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007051 ! spindle organization +is_a: GO:0031122 ! cytoplasmic microtubule organization + +[Term] +id: GO:0030954 +name: astral microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah] +is_a: GO:0030953 ! astral microtubule organization +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center + +[Term] +id: GO:0030955 +name: potassium ion binding +namespace: molecular_function +def: "Binding to a potassium ion (K+)." [GOC:mah] +synonym: "K ion binding" EXACT [] +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0030956 +name: glutamyl-tRNA(Gln) amidotransferase complex +namespace: cellular_component +def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. +synonym: "AdT" RELATED [GOC:rb] +synonym: "GatCAB" NARROW [GOC:rb] +synonym: "GatFAB" NARROW [GOC:rb] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0030957 +name: Tat protein binding +namespace: molecular_function +def: "Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0030958 +name: RITS complex +namespace: cellular_component +def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] +is_a: GO:0031332 ! RNAi effector complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000792 ! heterochromatin + +[Term] +id: GO:0030959 +name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine +namespace: biological_process +def: "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367] +xref: RESID:AA0367 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0030960 +name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine +namespace: biological_process +def: "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368] +xref: RESID:AA0368 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0030961 +name: peptidyl-arginine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah] +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0030962 +name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine +namespace: biological_process +def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369] +xref: RESID:AA0369 +is_a: GO:0030961 ! peptidyl-arginine hydroxylation + +[Term] +id: GO:0030963 +name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine +namespace: biological_process +def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370] +xref: RESID:AA0370 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0030964 +name: NADH dehydrogenase complex +namespace: cellular_component +alt_id: GO:0030025 +alt_id: GO:0030966 +alt_id: GO:0031675 +alt_id: GO:0031677 +alt_id: GO:0031678 +alt_id: GO:0045280 +def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. +subset: goslim_pir +synonym: "Complex I" EXACT [] +synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] +synonym: "NADH dehydrogenase complex (quinone)" NARROW [] +synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW [] +synonym: "NADH:plastoquinone reductase complex" NARROW [] +synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] +xref: Wikipedia:NADH_dehydrogenase +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0030965 +name: plasma membrane electron transport, NADH to quinone +namespace: biological_process +def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd] +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport + +[Term] +id: GO:0030968 +name: endoplasmic reticulum unfolded protein response +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763] +comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. +synonym: "ER unfolded protein response" EXACT [] +synonym: "erUPR" EXACT [] +synonym: "SREBP-mediated signalling pathway" RELATED [] +is_a: GO:0007165 ! signal transduction +is_a: GO:0034976 ! response to endoplasmic reticulum stress +relationship: part_of GO:0034620 ! cellular response to unfolded protein + +[Term] +id: GO:0030969 +name: obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241] +comment: The reason for obsoletion is that this process represent a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). +synonym: "HAC1 mRNA splicing" NARROW [PMID:21924241] +synonym: "IRE1-mediated XBP-1 mRNA splicing" NARROW [GOC:bf] +synonym: "Ire1p-mediated HAC-1 mRNA splicing" NARROW [GOC:bf] +synonym: "non-spliceosomal mRNA splicing in the unfolded protein response pathway" EXACT [PMID:10357823] +synonym: "spliceosome-independent UFP-specific transcription factor mRNA processing" EXACT [GOC:dph] +synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb] +synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response" EXACT [GOC:bf] +synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR" EXACT [GOC:bf] +synonym: "UFP-specific transcription factor mRNA processing involved in ER unfolded protein response" EXACT [GOC:bf] +synonym: "UFP-specific transcription factor mRNA processing involved in ER UPR" EXACT [GOC:bf] +synonym: "unconventional mRNA splicing involved in UPR" EXACT [GOC:bf] +synonym: "unconventional splicing of XBP1 mRNA" EXACT [PMID:11779464, PMID:26068456] +synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED [] +synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED [] +synonym: "XBP1 mRNA splicing" EXACT [PMID:11779464, PMID:25968568] +synonym: "XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress" NARROW [PMID:21924241] +synonym: "XBP1 mRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GOC:bf] +is_obsolete: true +consider: GO:0036498 + +[Term] +id: GO:0030970 +name: retrograde protein transport, ER to cytosol +namespace: biological_process +def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744] +synonym: "protein dislocation from ER" EXACT [GOC:dph, GOC:krc] +synonym: "protein retrotranslocation, ER to cytosol" EXACT [GOC:bf] +synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [] +is_a: GO:0032527 ! protein exit from endoplasmic reticulum +is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport +relationship: part_of GO:0036503 ! ERAD pathway + +[Term] +id: GO:0030971 +name: receptor tyrosine kinase binding +namespace: molecular_function +def: "Binding to a receptor that possesses protein tyrosine kinase activity." [GOC:mah] +synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:1990782 ! protein tyrosine kinase binding + +[Term] +id: GO:0030972 +name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis +namespace: biological_process +def: "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] +comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. +synonym: "apoptotic cleavage of cytosolic proteins" EXACT [] +synonym: "cleavage of cytosolic proteins involved in apoptosis" BROAD [] +synonym: "cleavage of cytosolic proteins involved in execution phase of apoptosis" EXACT [] +is_obsolete: true +consider: GO:0097200 + +[Term] +id: GO:0030973 +name: molybdate ion binding +namespace: molecular_function +def: "Binding to a molybdate ion (MoO4 2-)." [GOC:mlg] +synonym: "MoO4 ion binding" EXACT [] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0030974 +name: thiamine pyrophosphate transmembrane transport +namespace: biological_process +def: "The process in which thiamine pyrophosphate is transported across a membrane." [GOC:mlg] +synonym: "thiamin diphosphate transport" EXACT [] +synonym: "thiamin pyrophosphate transport" EXACT [] +synonym: "thiamine diphosphate transport" EXACT [] +synonym: "thiamine pyrophosphate transport" NARROW [] +synonym: "TPP transport" EXACT [] +is_a: GO:0015697 ! quaternary ammonium group transport +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0071934 ! thiamine transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0030975 +name: thiamine binding +namespace: molecular_function +def: "Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] +synonym: "thiamin binding" EXACT [] +synonym: "vitamin B1 binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0043169 ! cation binding +is_a: GO:0043178 ! alcohol binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0030976 +name: thiamine pyrophosphate binding +namespace: molecular_function +def: "Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [GOC:mlg] +synonym: "aneurine pyrophosphate binding" EXACT [] +synonym: "cocarboxylase binding" EXACT [] +synonym: "diphosphothiamin binding" EXACT [] +synonym: "thiamin pyrophosphate binding" EXACT [] +synonym: "TPP binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0043168 ! anion binding +is_a: GO:0043169 ! cation binding +is_a: GO:0050997 ! quaternary ammonium group binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0030977 +name: taurine binding +namespace: molecular_function +def: "Binding to taurine." [GOC:mlg] +is_a: GO:0043177 ! organic acid binding +is_a: GO:0043210 ! alkanesulfonate binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0030978 +name: alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] +synonym: "alpha-glucan metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process + +[Term] +id: GO:0030979 +name: alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] +synonym: "alpha-glucan anabolism" EXACT [] +synonym: "alpha-glucan biosynthesis" EXACT [] +synonym: "alpha-glucan formation" EXACT [] +synonym: "alpha-glucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0030980 +name: alpha-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah] +synonym: "alpha-glucan breakdown" EXACT [] +synonym: "alpha-glucan catabolism" EXACT [] +synonym: "alpha-glucan degradation" EXACT [] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0030978 ! alpha-glucan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process + +[Term] +id: GO:0030981 +name: cortical microtubule cytoskeleton +namespace: cellular_component +def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] +is_a: GO:0030863 ! cortical cytoskeleton +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:0030982 +name: adventurous gliding motility +namespace: biological_process +def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173] +synonym: "adventurous gliding movement" EXACT [] +is_a: GO:0071976 ! cell gliding + +[Term] +id: GO:0030983 +name: mismatched DNA binding +namespace: molecular_function +alt_id: GO:0032134 +def: "Binding to a double-stranded DNA region containing one or more mismatches." [GOC:mah] +synonym: "mispair binding" EXACT [] +synonym: "mispaired DNA binding" EXACT [] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0030984 +name: kininogen binding +namespace: molecular_function +def: "Binding to a kininogen, a kinin precursor." [GOC:mah, PMID:9520414] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0030985 +name: high molecular weight kininogen binding +namespace: molecular_function +def: "Binding to a kininogen of high molecular mass." [GOC:mah, PMID:9520414] +synonym: "HK binding" EXACT [] +synonym: "HMW kininogen binding" EXACT [] +is_a: GO:0030984 ! kininogen binding + +[Term] +id: GO:0030986 +name: low molecular weight kininogen binding +namespace: molecular_function +def: "Binding to a kininogen of low molecular mass." [GOC:mah, PMID:9520414] +synonym: "LK binding" EXACT [] +synonym: "LMW kininogen binding" EXACT [] +is_a: GO:0030984 ! kininogen binding + +[Term] +id: GO:0030987 +name: high molecular weight kininogen receptor binding +namespace: molecular_function +def: "Binding to a high molecular weight kininogen receptor." [GOC:mah] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0030988 +name: high molecular weight kininogen receptor complex +namespace: cellular_component +def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0030989 +name: dynein-driven meiotic oscillatory nuclear movement +namespace: biological_process +def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142] +comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination. +synonym: "HNM" EXACT [] +synonym: "horsetail movement" EXACT [] +synonym: "horsetail nuclear movement" EXACT [GOC:vw] +is_a: GO:0030473 ! nuclear migration along microtubule +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0030990 +name: intraciliary transport particle +namespace: cellular_component +def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] +comment: Note that we deem cilia and microtubule-based flagella to be equivalent. +subset: goslim_pir +synonym: "IFT complex" RELATED [] +synonym: "intraflagellar transport complex" EXACT [] +synonym: "intraflagellar transport particle" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0030991 +name: intraciliary transport particle A +namespace: cellular_component +def: "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576] +comment: Note that we deem cilia and microtubule-based flagella to be equivalent. +synonym: "IFT A complex" RELATED [] +synonym: "IFT complex A" RELATED [] +synonym: "intraflagellar transport complex A" EXACT [] +synonym: "intraflagellar transport particle A" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030990 ! intraciliary transport particle + +[Term] +id: GO:0030992 +name: intraciliary transport particle B +namespace: cellular_component +def: "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336] +comment: Note that we deem cilia and microtubule-based flagella to be equivalent. +synonym: "IFT B complex" RELATED [] +synonym: "IFT complex B" RELATED [] +synonym: "intraflagellar transport complex B" EXACT [] +synonym: "intraflagellar transport particle B" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030990 ! intraciliary transport particle + +[Term] +id: GO:0030993 +name: axonemal heterotrimeric kinesin-II complex +namespace: cellular_component +def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0030994 +name: primary cell septum disassembly +namespace: biological_process +def: "Dissolution of the primary septum during cell separation." [PMID:12665550] +synonym: "hydrolysis of primary cell septum" EXACT [] +synonym: "primary cell septum hydrolysis" EXACT [] +synonym: "primary septum hydrolysis" BROAD [] +is_a: GO:0022411 ! cellular component disassembly +relationship: part_of GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:0030995 +name: cell septum edging catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814] +synonym: "cell septum edging hydrolysis" EXACT [] +synonym: "hydrolysis of cell septum edging" EXACT [] +synonym: "hydrolysis of edging of cell septum" EXACT [] +synonym: "septum edging hydrolysis" BROAD [] +is_a: GO:0071999 ! extracellular polysaccharide catabolic process +relationship: part_of GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:0030996 +name: obsolete mitotic cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] +comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. +synonym: "cell cycle arrest in response to nitrogen starvation" BROAD [] +is_obsolete: true + +[Term] +id: GO:0030997 +name: regulation of centriole-centriole cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: part_of GO:0007098 ! centrosome cycle +relationship: regulates GO:0010457 ! centriole-centriole cohesion + +[Term] +id: GO:0030998 +name: linear element +namespace: cellular_component +def: "A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex." [DOI:10.2323/jgam.28.263, GOC:jb, PMID:12665553, PMID:30640914] +is_a: GO:0099086 ! synaptonemal structure + +[Term] +id: GO:0030999 +name: linear element assembly +namespace: biological_process +def: "The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex." [GOC:jb, GOC:mah, PMID:30640914] +synonym: "linear element formation" RELATED [GOC:dph] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis + +[Term] +id: GO:0031000 +name: response to caffeine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:ef, GOC:mah] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0031001 +name: response to brefeldin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0046677 ! response to antibiotic +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0031002 +name: actin rod +namespace: cellular_component +def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions." [GOC:kp, GOC:krc, PMID:11858703, PMID:19459188, PMID:22623727, PMID:24813767, PMID:27535426, PMID:7820870] +is_a: GO:0032432 ! actin filament bundle + +[Term] +id: GO:0031003 +name: actin tubule +namespace: cellular_component +def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] +is_a: GO:0032432 ! actin filament bundle +relationship: part_of GO:0031002 ! actin rod + +[Term] +id: GO:0031004 +name: potassium ion-transporting ATPase complex +namespace: cellular_component +def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692] +synonym: "Kdp system complex" EXACT [] +is_a: GO:0090533 ! cation-transporting ATPase complex + +[Term] +id: GO:0031005 +name: filamin binding +namespace: molecular_function +alt_id: GO:0031006 +alt_id: GO:0031007 +alt_id: GO:0031008 +def: "Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] +synonym: "ABP-278/276 binding" NARROW [] +synonym: "ABP-280 binding" NARROW [] +synonym: "ABPL binding" NARROW [] +synonym: "alpha-filamin binding" NARROW [] +synonym: "beta-filamin binding" NARROW [] +synonym: "filamin A binding" NARROW [] +synonym: "filamin B binding" NARROW [] +synonym: "filamin C binding" EXACT [] +synonym: "filamin-1 binding" NARROW [] +synonym: "filamin-2 binding" NARROW [] +synonym: "filamin-3 binding" NARROW [] +synonym: "filamin-A binding" NARROW [] +synonym: "filamin-B binding" EXACT [] +synonym: "filamin-C binding" NARROW [] +synonym: "gamma-filamin binding" NARROW [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031009 +name: plastid ADPG pyrophosphorylase complex +namespace: cellular_component +def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] +is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0031010 +name: ISWI-type complex +namespace: cellular_component +def: "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0031011 +name: Ino80 complex +namespace: cellular_component +def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity." [GOC:jh, GOC:rb, PMID:19355820] +synonym: "INO80 chromatin remodeling complex" EXACT [] +is_a: GO:0097346 ! INO80-type complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0031012 +name: extracellular matrix +namespace: cellular_component +alt_id: GO:0005578 +def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +synonym: "matrisome" NARROW [] +synonym: "proteinaceous extracellular matrix" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090513 +xref: Wikipedia:Extracellular_matrix +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0031013 +name: troponin I binding +namespace: molecular_function +def: "Binding to troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031014 +name: troponin T binding +namespace: molecular_function +def: "Binding to troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031015 +name: obsolete karyopherin docking complex +namespace: cellular_component +def: "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] +synonym: "Asm4p-containing complex" NARROW [] +synonym: "karyopherin docking complex" EXACT [] +synonym: "nuclear pore subcomplex" BROAD [] +is_obsolete: true +consider: GO:0017056 +consider: GO:0044613 + +[Term] +id: GO:0031016 +name: pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] +xref: Wikipedia:Pancreas +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0031017 +name: exocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035272 ! exocrine system development +relationship: part_of GO:0055123 ! digestive system development + +[Term] +id: GO:0031018 +name: endocrine pancreas development +namespace: biological_process +def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0031016 ! pancreas development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0031019 +name: mitochondrial mRNA editing complex +namespace: cellular_component +def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] +synonym: "mitochondrial editosome" EXACT [] +is_a: GO:0045293 ! mRNA editing complex +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0031020 +name: plastid mRNA editing complex +namespace: cellular_component +def: "An mRNA editing complex found in a plastid." [GOC:mah] +synonym: "plastid editosome" EXACT [] +is_a: GO:0045293 ! mRNA editing complex +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0031021 +name: interphase microtubule organizing center +namespace: cellular_component +def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] +synonym: "iMTOC" EXACT [] +synonym: "interphase microtubule organising center" EXACT [] +synonym: "interphase MTOC" EXACT [] +is_a: GO:0005815 ! microtubule organizing center + +[Term] +id: GO:0031022 +name: nuclear migration along microfilament +namespace: biological_process +def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] +synonym: "nuclear migration, microfilament-mediated" EXACT [] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0099515 ! actin filament-based transport + +[Term] +id: GO:0031023 +name: microtubule organizing center organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "microtubule organising center organisation" EXACT [] +synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031024 +name: interphase microtubule organizing center assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790] +synonym: "interphase microtubule organising center biosynthesis" EXACT [] +synonym: "interphase microtubule organising center formation" EXACT [] +synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah] +synonym: "interphase microtubule organizing centre assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0031025 +name: equatorial microtubule organizing center disassembly +namespace: biological_process +def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790] +synonym: "equatorial microtubule organising center disassembly" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0031023 ! microtubule organizing center organization +is_a: GO:0031121 ! equatorial microtubule organization + +[Term] +id: GO:0031026 +name: glutamate synthase complex +namespace: cellular_component +def: "A complex that possesses glutamate synthase activity." [GOC:mah] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0031027 +name: glutamate synthase complex (NADH) +namespace: cellular_component +def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] +is_a: GO:0031026 ! glutamate synthase complex + +[Term] +id: GO:0031028 +name: septation initiation signaling +namespace: biological_process +def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] +synonym: "septation initiation network" EXACT [] +synonym: "septation initiation signaling cascade" RELATED [GOC:signaling] +synonym: "septation initiation signalling" EXACT [] +synonym: "SIN" EXACT [] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0031029 +name: regulation of septation initiation signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "regulation of septation initiation network" EXACT [] +synonym: "regulation of septation initiation signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of septation initiation signalling" EXACT [] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031030 +name: negative regulation of septation initiation signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "down regulation of septation initiation signaling" EXACT [] +synonym: "down-regulation of septation initiation signaling" EXACT [] +synonym: "downregulation of septation initiation signaling" EXACT [] +synonym: "inhibition of septation initiation signaling" NARROW [] +synonym: "negative regulation of septation initiation network" EXACT [] +synonym: "negative regulation of septation initiation signaling cascade" RELATED [GOC:signaling] +synonym: "negative regulation of septation initiation signalling" EXACT [] +is_a: GO:0010974 ! negative regulation of division septum assembly +is_a: GO:0031029 ! regulation of septation initiation signaling +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031031 +name: positive regulation of septation initiation signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] +synonym: "activation of septation initiation signaling" NARROW [] +synonym: "positive regulation of septation initiation network" EXACT [] +synonym: "positive regulation of septation initiation signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of septation initiation signalling" EXACT [] +synonym: "stimulation of septation initiation signaling" NARROW [] +synonym: "up regulation of septation initiation signaling" EXACT [] +synonym: "up-regulation of septation initiation signaling" EXACT [] +synonym: "upregulation of septation initiation signaling" EXACT [] +is_a: GO:0010973 ! positive regulation of division septum assembly +is_a: GO:0031029 ! regulation of septation initiation signaling +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0031028 ! septation initiation signaling + +[Term] +id: GO:0031032 +name: actomyosin structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] +comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. +synonym: "actomyosin organization" EXACT [] +synonym: "actomyosin structure organisation" EXACT [] +synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0031033 +name: myosin filament organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] +comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. +synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah] +synonym: "myosin filament organisation" EXACT [GOC:mah] +synonym: "myosin polymerization or depolymerization" RELATED [] +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0031034 +name: myosin filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah] +synonym: "myosin polymerization" RELATED [] +is_a: GO:0031033 ! myosin filament organization +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0031035 +name: myosin filament disassembly +namespace: biological_process +def: "The disassembly of a filament composed of myosin molecules." [GOC:mah] +synonym: "myosin depolymerization" RELATED [] +is_a: GO:0031033 ! myosin filament organization +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0031036 +name: myosin II filament assembly +namespace: biological_process +def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II polymerization" RELATED [] +is_a: GO:0031034 ! myosin filament assembly +is_a: GO:0031038 ! myosin II filament organization + +[Term] +id: GO:0031037 +name: myosin II filament disassembly +namespace: biological_process +def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II depolymerization" RELATED [] +is_a: GO:0031035 ! myosin filament disassembly +is_a: GO:0031038 ! myosin II filament organization + +[Term] +id: GO:0031038 +name: myosin II filament organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] +synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah] +synonym: "myosin II filament organisation" EXACT [GOC:mah] +synonym: "myosin II polymerization or depolymerization" RELATED [] +is_a: GO:0031033 ! myosin filament organization + +[Term] +id: GO:0031039 +name: macronucleus +namespace: cellular_component +def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] +xref: Wikipedia:Macronucleus +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0031040 +name: micronucleus +namespace: cellular_component +def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] +xref: Wikipedia:Micronucleus +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0031041 +name: O-glycan processing, core 5 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031042 +name: O-glycan processing, core 6 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031043 +name: O-glycan processing, core 7 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031044 +name: O-glycan processing, core 8 +namespace: biological_process +def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] +is_a: GO:0016266 ! O-glycan processing + +[Term] +id: GO:0031045 +name: dense core granule +namespace: cellular_component +def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] +synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] +xref: NIF_Subcellular:sao772007592 +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0031047 +name: gene silencing by RNA +namespace: biological_process +def: "A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation." [PMID:15020054] +subset: goslim_drosophila +subset: goslim_generic +synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010629 ! negative regulation of gene expression + +[Term] +id: GO:0031048 +name: heterochromatin assembly by small RNA +namespace: biological_process +alt_id: GO:0070924 +def: "Assembly of heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns, PMID:19239886] +synonym: "chromatin silencing by small RNA" RELATED [] +synonym: "heterochromatin assembly involved in chromatin silencing by small RNA" RELATED [] +synonym: "heterochromatin formation involved in chromatin silencing by small RNA" RELATED [] +synonym: "RNA interference-like chromatin silencing" EXACT [] +synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] +synonym: "RNA-mediated TGS" BROAD [] +synonym: "RNA-mediated transcriptional silencing" EXACT [] +synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw] +synonym: "RNAi-like chromatin silencing" EXACT [] +synonym: "small RNA-mediated heterochromatic silencing" EXACT [] +synonym: "small RNA-mediated heterochromatin formation" RELATED [GOC:mah] +is_a: GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0031049 +name: programmed DNA elimination +namespace: biological_process +def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] +subset: goslim_pir +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0031051 +name: scnRNA processing +namespace: biological_process +def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465] +synonym: "scnRNA production" BROAD [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0031049 ! programmed DNA elimination + +[Term] +id: GO:0031052 +name: chromosome breakage +namespace: biological_process +def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] +comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. +synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] +is_a: GO:0051276 ! chromosome organization +relationship: part_of GO:0031049 ! programmed DNA elimination + +[Term] +id: GO:0031053 +name: primary miRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354] +synonym: "pri-miRNA processing" EXACT [] +synonym: "primary microRNA processing" EXACT [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:0031054 +name: pre-miRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354] +synonym: "pre-microRNA processing" EXACT [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:0031055 +name: chromatin remodeling at centromere +namespace: biological_process +def: "Dynamic structural changes in centromeric DNA." [GOC:mah] +is_a: GO:0006338 ! chromatin remodeling + +[Term] +id: GO:0031056 +name: regulation of histone modification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031057 +name: negative regulation of histone modification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +synonym: "down regulation of histone modification" EXACT [] +synonym: "down-regulation of histone modification" EXACT [] +synonym: "downregulation of histone modification" EXACT [] +synonym: "inhibition of histone modification" NARROW [] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031400 ! negative regulation of protein modification process +relationship: negatively_regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031058 +name: positive regulation of histone modification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] +synonym: "activation of histone modification" NARROW [] +synonym: "stimulation of histone modification" NARROW [] +synonym: "up regulation of histone modification" EXACT [] +synonym: "up-regulation of histone modification" EXACT [] +synonym: "upregulation of histone modification" EXACT [] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031401 ! positive regulation of protein modification process +relationship: positively_regulates GO:0016570 ! histone modification + +[Term] +id: GO:0031059 +name: histone deacetylation at centromere +namespace: biological_process +def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +is_a: GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031060 +name: regulation of histone methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031061 +name: negative regulation of histone methylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +synonym: "down regulation of histone methylation" EXACT [] +synonym: "down-regulation of histone methylation" EXACT [] +synonym: "downregulation of histone methylation" EXACT [] +synonym: "inhibition of histone methylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031060 ! regulation of histone methylation +relationship: negatively_regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031062 +name: positive regulation of histone methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] +synonym: "activation of histone methylation" NARROW [] +synonym: "stimulation of histone methylation" NARROW [] +synonym: "up regulation of histone methylation" EXACT [] +synonym: "up-regulation of histone methylation" EXACT [] +synonym: "upregulation of histone methylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031060 ! regulation of histone methylation +relationship: positively_regulates GO:0016571 ! histone methylation + +[Term] +id: GO:0031063 +name: regulation of histone deacetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0090311 ! regulation of protein deacetylation +relationship: regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031064 +name: negative regulation of histone deacetylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +synonym: "down regulation of histone deacetylation" EXACT [] +synonym: "down-regulation of histone deacetylation" EXACT [] +synonym: "downregulation of histone deacetylation" EXACT [] +synonym: "inhibition of histone deacetylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031063 ! regulation of histone deacetylation +relationship: negatively_regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031065 +name: positive regulation of histone deacetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] +synonym: "activation of histone deacetylation" NARROW [] +synonym: "stimulation of histone deacetylation" NARROW [] +synonym: "up regulation of histone deacetylation" EXACT [] +synonym: "up-regulation of histone deacetylation" EXACT [] +synonym: "upregulation of histone deacetylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031063 ! regulation of histone deacetylation +is_a: GO:0090312 ! positive regulation of protein deacetylation +relationship: positively_regulates GO:0016575 ! histone deacetylation + +[Term] +id: GO:0031066 +name: regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +is_a: GO:0031063 ! regulation of histone deacetylation +relationship: regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031067 +name: negative regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah] +synonym: "down regulation of histone deacetylation at centromere" EXACT [] +synonym: "down-regulation of histone deacetylation at centromere" EXACT [] +synonym: "downregulation of histone deacetylation at centromere" EXACT [] +synonym: "inhibition of histone deacetylation at centromere" NARROW [] +is_a: GO:0031064 ! negative regulation of histone deacetylation +is_a: GO:0031066 ! regulation of histone deacetylation at centromere +relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031068 +name: positive regulation of histone deacetylation at centromere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] +synonym: "activation of histone deacetylation at centromere" NARROW [] +synonym: "stimulation of histone deacetylation at centromere" NARROW [] +synonym: "up regulation of histone deacetylation at centromere" EXACT [] +synonym: "up-regulation of histone deacetylation at centromere" EXACT [] +synonym: "upregulation of histone deacetylation at centromere" EXACT [] +is_a: GO:0031065 ! positive regulation of histone deacetylation +is_a: GO:0031066 ! regulation of histone deacetylation at centromere +relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere + +[Term] +id: GO:0031069 +name: hair follicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0022405 ! hair cycle process +relationship: part_of GO:0001942 ! hair follicle development +relationship: part_of GO:0048730 ! epidermis morphogenesis + +[Term] +id: GO:0031070 +name: intronic snoRNA processing +namespace: biological_process +def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw] +is_a: GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:0031071 +name: cysteine desulfurase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] +synonym: "cysteine desulfurylase activity" RELATED [EC:2.8.1.7] +synonym: "IscS" RELATED [EC:2.8.1.7] +synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" RELATED [EC:2.8.1.7] +synonym: "NIFS" RELATED [EC:2.8.1.7] +synonym: "SufS" RELATED [EC:2.8.1.7] +xref: EC:2.8.1.7 +xref: Reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" +xref: Reactome:R-HSA-947514 "PXLP-K258-NFS1 transfers sulfur from cysteine onto MOCS3" +xref: RHEA:43892 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0031072 +name: heat shock protein binding +namespace: molecular_function +def: "Binding to a heat shock protein, a protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031073 +name: cholesterol 26-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0031074 +name: nucleocytoplasmic transport complex +namespace: cellular_component +def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "nucleocytoplasmic shuttling complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0031076 +name: embryonic camera-type eye development +namespace: biological_process +def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] +synonym: "embryonic eye development" EXACT [] +is_a: GO:0043010 ! camera-type eye development +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0031077 +name: post-embryonic camera-type eye development +namespace: biological_process +def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] +synonym: "post-embryonic camera-style eye development" EXACT [] +is_a: GO:0043010 ! camera-type eye development +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0009791 ! post-embryonic development + +[Term] +id: GO:0031078 +name: histone deacetylase activity (H3-K14 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [PMID:28450737] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0031079 +name: obsolete picornain 3C activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] +comment: This term was made obsolete because it represents a gene product. +synonym: "3C protease activity" RELATED [EC:3.4.22.28] +synonym: "3C proteinase activity" RELATED [EC:3.4.22.28] +synonym: "coxsackievirus 3C proteinase activity" RELATED [EC:3.4.22.28] +synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "hepatitis A virus 3C proteinase activity" RELATED [EC:3.4.22.28] +synonym: "picornain 3C activity" EXACT [] +synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] +synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "protease 3C" RELATED [EC:3.4.22.28] +synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] +synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] +synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0031080 +name: nuclear pore outer ring +namespace: cellular_component +def: "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "Nup107-120 complex" EXACT [] +synonym: "Nup107-160 complex" EXACT [] +synonym: "Nup84 complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0031082 +name: BLOC complex +namespace: cellular_component +def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] +subset: goslim_pir +synonym: "BLOC-1 related complex" EXACT [PMID:25898167] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0031083 +name: BLOC-1 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031084 +name: BLOC-2 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031085 +name: BLOC-3 complex +namespace: cellular_component +def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] +is_a: GO:0031082 ! BLOC complex + +[Term] +id: GO:0031086 +name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay +namespace: biological_process +def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] +synonym: "deadenylation-independent mRNA decay" EXACT [] +synonym: "deadenylylation-independent mRNA decay" EXACT [] +synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] +synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] +synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] +synonym: "mRNA catabolism, deadenylation-independent" EXACT [] +synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] +synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] +synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] +synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0031087 +name: deadenylation-independent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] +synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] +synonym: "deadenylylation-independent decapping" EXACT [] +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis +is_a: GO:0110156 ! methylguanosine-cap decapping +relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay + +[Term] +id: GO:0031088 +name: platelet dense granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042827 ! platelet dense granule + +[Term] +id: GO:0031089 +name: platelet dense granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0042827 ! platelet dense granule + +[Term] +id: GO:0031090 +name: organelle membrane +namespace: cellular_component +def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] +synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] +xref: NIF_Subcellular:sao830981606 +is_a: GO:0016020 ! membrane +relationship: part_of GO:0043227 ! membrane-bounded organelle + +[Term] +id: GO:0031091 +name: platelet alpha granule +namespace: cellular_component +def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] +synonym: "platelet alpha-granule" EXACT [] +xref: Wikipedia:Platelet_alpha-granule +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0031092 +name: platelet alpha granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] +synonym: "platelet alpha-granule membrane" EXACT [] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0031091 ! platelet alpha granule + +[Term] +id: GO:0031093 +name: platelet alpha granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] +synonym: "platelet alpha-granule lumen" EXACT [] +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0031091 ! platelet alpha granule + +[Term] +id: GO:0031094 +name: platelet dense tubular network +namespace: cellular_component +def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0031095 +name: platelet dense tubular network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0031094 ! platelet dense tubular network + +[Term] +id: GO:0031096 +name: platelet dense tubular network lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0031094 ! platelet dense tubular network + +[Term] +id: GO:0031097 +name: medial cortex +namespace: cellular_component +def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789] +synonym: "medial ring" EXACT [GOC:vw] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0031098 +name: stress-activated protein kinase signaling cascade +namespace: biological_process +def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] +synonym: "JNK signaling pathway" NARROW [] +synonym: "JNK signalling pathway" NARROW [] +synonym: "SAPK signaling pathway" EXACT [] +synonym: "SAPK signalling pathway" EXACT [] +synonym: "stress-activated protein kinase signaling pathway" EXACT [] +synonym: "stress-activated protein kinase signalling pathway" EXACT [] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0031099 +name: regeneration +namespace: biological_process +def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] +xref: Wikipedia:Regeneration_(biology) +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0031100 +name: animal organ regeneration +namespace: biological_process +def: "The regrowth of a lost or destroyed animal organ." [GOC:mah] +is_a: GO:0031099 ! regeneration +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0031101 +name: fin regeneration +namespace: biological_process +def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0031102 +name: neuron projection regeneration +namespace: biological_process +def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] +synonym: "neurite regeneration" NARROW [GOC:mah] +is_a: GO:0031099 ! regeneration +is_a: GO:0031175 ! neuron projection development +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0031103 +name: axon regeneration +namespace: biological_process +def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] +is_a: GO:0031102 ! neuron projection regeneration +is_a: GO:0048678 ! response to axon injury +is_a: GO:0061564 ! axon development + +[Term] +id: GO:0031104 +name: dendrite regeneration +namespace: biological_process +def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] +is_a: GO:0016358 ! dendrite development +is_a: GO:0031102 ! neuron projection regeneration + +[Term] +id: GO:0031105 +name: septin complex +namespace: cellular_component +def: "A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005938 ! cell cortex +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0031106 +name: septin ring organization +namespace: biological_process +def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] +synonym: "septin ring organisation" EXACT [] +is_a: GO:0032185 ! septin cytoskeleton organization + +[Term] +id: GO:0031107 +name: septin ring disassembly +namespace: biological_process +def: "The controlled breakdown of a septin ring." [GOC:mah] +is_a: GO:0031106 ! septin ring organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0031108 +name: holo-[acyl-carrier-protein] biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg] +synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT [] +synonym: "holo-[acyl-carrier-protein] anabolism" EXACT [] +synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT [] +synonym: "holo-[acyl-carrier-protein] formation" EXACT [] +synonym: "holo-[acyl-carrier-protein] synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0019538 ! protein metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0031109 +name: microtubule polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031110 +name: regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] +is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization +relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031111 +name: negative regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] +synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031112 +name: positive regulation of microtubule polymerization or depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] +synonym: "activation of microtubule polymerization or depolymerization" NARROW [] +synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] +synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] +synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization + +[Term] +id: GO:0031113 +name: regulation of microtubule polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:0032271 ! regulation of protein polymerization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031114 +name: regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] +synonym: "regulation of microtubule disassembly" EXACT [] +is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization +is_a: GO:1901879 ! regulation of protein depolymerization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0031115 +name: negative regulation of microtubule polymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] +synonym: "down regulation of microtubule polymerization" EXACT [] +synonym: "down-regulation of microtubule polymerization" EXACT [] +synonym: "downregulation of microtubule polymerization" EXACT [] +synonym: "inhibition of microtubule polymerization" NARROW [] +is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization +is_a: GO:0031113 ! regulation of microtubule polymerization +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031116 +name: positive regulation of microtubule polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] +synonym: "activation of microtubule polymerization" NARROW [] +synonym: "stimulation of microtubule polymerization" NARROW [] +synonym: "up regulation of microtubule polymerization" EXACT [] +synonym: "up-regulation of microtubule polymerization" EXACT [] +synonym: "upregulation of microtubule polymerization" EXACT [] +is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization +is_a: GO:0031113 ! regulation of microtubule polymerization +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0046785 ! microtubule polymerization + +[Term] +id: GO:0031117 +name: positive regulation of microtubule depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] +synonym: "activation of microtubule depolymerization" NARROW [] +synonym: "microtubule destabilization" EXACT [] +synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of microtubule disassembly" EXACT [] +synonym: "stimulation of microtubule depolymerization" NARROW [] +synonym: "up regulation of microtubule depolymerization" EXACT [] +synonym: "up-regulation of microtubule depolymerization" EXACT [] +synonym: "upregulation of microtubule depolymerization" EXACT [] +is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization +is_a: GO:0031114 ! regulation of microtubule depolymerization +is_a: GO:1901881 ! positive regulation of protein depolymerization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0031118 +name: rRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0001522 ! pseudouridine synthesis + +[Term] +id: GO:0031119 +name: tRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah] +is_a: GO:0001522 ! pseudouridine synthesis +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0031120 +name: snRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah] +is_a: GO:0001522 ! pseudouridine synthesis +is_a: GO:0040031 ! snRNA modification + +[Term] +id: GO:0031121 +name: equatorial microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw] +synonym: "equatorial microtubule organisation" EXACT [] +synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0031122 +name: cytoplasmic microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] +synonym: "cytoplasmic microtubule organisation" EXACT [] +synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0031123 +name: RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] +synonym: "RNA 3' end processing" EXACT [] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0031124 +name: mRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] +synonym: "mRNA 3' end processing" EXACT [] +is_a: GO:0006397 ! mRNA processing +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0031125 +name: rRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah] +synonym: "rRNA 3' end processing" EXACT [] +is_a: GO:0006364 ! rRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0031126 +name: sno(s)RNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea." [GOC:krc, GOC:mah, PMID:17284456] +synonym: "sno(s)RNA 3' end processing" EXACT [] +synonym: "snoRNA 3'-end processing" NARROW [] +synonym: "sRNA 3'-end processing" NARROW [] +is_a: GO:0043144 ! sno(s)RNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0031127 +name: alpha-(1,2)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage." [GOC:mah] +synonym: "alpha-(1->2)-fucosyltransferase activity" EXACT [] +synonym: "alpha-1,2-fucosyltransferase activity" EXACT [] +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0031128 +name: developmental induction +namespace: biological_process +def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0031129 +name: inductive cell-cell signaling +namespace: biological_process +def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah] +synonym: "inductive cell-cell signalling" EXACT [] +is_a: GO:0031128 ! developmental induction + +[Term] +id: GO:0031130 +name: creation of an inductive signal +namespace: biological_process +def: "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah] +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0031131 +name: reception of an inductive signal +namespace: biological_process +def: "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah] +is_a: GO:0031668 ! cellular response to extracellular stimulus +relationship: part_of GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0031132 +name: serine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH." [EC:1.1.1.276, RHEA:21596] +synonym: "L-serine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.276] +xref: EC:1.1.1.276 +xref: KEGG_REACTION:R06126 +xref: MetaCyc:RXN0-2201 +xref: RHEA:21596 +xref: Wikipedia:Serine_3-dehydrogenase +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0031133 +name: regulation of axon diameter +namespace: biological_process +def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0032536 ! regulation of cell projection size +is_a: GO:0050770 ! regulation of axonogenesis + +[Term] +id: GO:0031134 +name: sister chromatid biorientation +namespace: biological_process +def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] +synonym: "chromosome biorientation" EXACT [] +synonym: "sister kinetochore biorientation" EXACT [] +is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore +relationship: part_of GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0031135 +name: negative regulation of conjugation +namespace: biological_process +def: "Any process that decreases the rate of conjugation." [GOC:mah] +synonym: "down regulation of conjugation" EXACT [] +synonym: "down-regulation of conjugation" EXACT [] +synonym: "downregulation of conjugation" EXACT [] +synonym: "inhibition of conjugation" NARROW [] +is_a: GO:0046999 ! regulation of conjugation +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0000746 ! conjugation + +[Term] +id: GO:0031136 +name: positive regulation of conjugation +namespace: biological_process +def: "Any process that increases the rate or frequency of conjugation." [GOC:mah] +synonym: "activation of conjugation" NARROW [] +synonym: "stimulation of conjugation" NARROW [] +synonym: "up regulation of conjugation" EXACT [] +synonym: "up-regulation of conjugation" EXACT [] +synonym: "upregulation of conjugation" EXACT [] +is_a: GO:0046999 ! regulation of conjugation +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0000746 ! conjugation + +[Term] +id: GO:0031137 +name: regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] +is_a: GO:0046999 ! regulation of conjugation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031138 +name: negative regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah] +synonym: "down regulation of conjugation with cellular fusion" EXACT [] +synonym: "down-regulation of conjugation with cellular fusion" EXACT [] +synonym: "downregulation of conjugation with cellular fusion" EXACT [] +synonym: "inhibition of conjugation with cellular fusion" NARROW [] +is_a: GO:0031135 ! negative regulation of conjugation +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031139 +name: positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah] +synonym: "activation of conjugation with cellular fusion" NARROW [] +synonym: "stimulation of conjugation with cellular fusion" NARROW [] +synonym: "up regulation of conjugation with cellular fusion" EXACT [] +synonym: "up-regulation of conjugation with cellular fusion" EXACT [] +synonym: "upregulation of conjugation with cellular fusion" EXACT [] +is_a: GO:0031136 ! positive regulation of conjugation +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0031140 +name: induction of conjugation upon nutrient starvation +namespace: biological_process +def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah] +is_a: GO:0010514 ! induction of conjugation with cellular fusion + +[Term] +id: GO:0031141 +name: induction of conjugation upon carbon starvation +namespace: biological_process +def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah] +is_a: GO:0031140 ! induction of conjugation upon nutrient starvation + +[Term] +id: GO:0031142 +name: induction of conjugation upon nitrogen starvation +namespace: biological_process +def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah] +is_a: GO:0006995 ! cellular response to nitrogen starvation +is_a: GO:0031140 ! induction of conjugation upon nutrient starvation + +[Term] +id: GO:0031143 +name: pseudopodium +namespace: cellular_component +def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732] +subset: goslim_pir +synonym: "axopodium" NARROW [] +synonym: "lobopodium" NARROW [] +synonym: "pseudopod" EXACT [] +synonym: "pseudopodial protrusion" EXACT [] +synonym: "reticulopodium" NARROW [] +xref: Wikipedia:Pseudopod +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0031144 +name: proteasome localization +namespace: biological_process +def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of proteasome localization" EXACT [] +synonym: "proteasome localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0031145 +name: anaphase-promoting complex-dependent catabolic process +namespace: biological_process +alt_id: GO:0008054 +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] +synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "cyclin breakdown" NARROW [] +synonym: "cyclin catabolic process" NARROW [] +synonym: "cyclin catabolism" NARROW [] +synonym: "cyclin degradation" NARROW [] +synonym: "degradation of cyclin" NARROW [] +synonym: "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW [] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0031146 +name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0031147 +name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT [] +synonym: "DIF-1 metabolic process" EXACT [] +synonym: "DIF-1 metabolism" EXACT [] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0031148 +name: DIF-1 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT [] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT [] +synonym: "DIF-1 biosynthesis" EXACT [] +is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0031149 +name: sorocarp stalk cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640, PMID:4338436] +synonym: "stalk cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0031150 ! sorocarp stalk development + +[Term] +id: GO:0031150 +name: sorocarp stalk development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [GOC:mtg_sensu, ISBN:0521583640, PMID:4338436] +synonym: "sorophore development" EXACT [] +synonym: "stalk development" BROAD [] +synonym: "stalk formation" BROAD [] +is_a: GO:0099120 ! socially cooperative development +relationship: part_of GO:0031154 ! culmination involved in sorocarp development + +[Term] +id: GO:0031151 +name: histone methyltransferase activity (H3-K79 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] +synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT [] +synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0031152 +name: aggregation involved in sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "aggregate development involved in sorocarp development" EXACT [] +synonym: "aggregation during fruiting body development" EXACT [] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0099120 ! socially cooperative development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031153 +name: slug development involved in sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "migratory slug development during sorocarp development" NARROW [] +synonym: "pseudoplasmodium biosynthesis" EXACT [] +synonym: "pseudoplasmodium formation" EXACT [] +synonym: "slug development during fruiting body development" EXACT [] +synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb] +synonym: "standing slug development during sorocarp development" NARROW [] +is_a: GO:0099120 ! socially cooperative development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031154 +name: culmination involved in sorocarp development +namespace: biological_process +def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] +synonym: "culminant development" EXACT [] +synonym: "culmination during fruiting body development" EXACT [] +synonym: "culmination during sorocarp development" RELATED [] +is_a: GO:0099120 ! socially cooperative development +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031155 +name: regulation of reproductive fruiting body development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reproductive fruiting body development." [GOC:mah] +synonym: "regulation of fruiting body formation" EXACT [] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0030582 ! reproductive fruiting body development + +[Term] +id: GO:0031156 +name: regulation of sorocarp development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [GOC:mah, GOC:mtg_sensu, PMID:4332228] +synonym: "regulation of fruiting body development" BROAD [] +synonym: "regulation of fruiting body formation" BROAD [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0030587 ! sorocarp development + +[Term] +id: GO:0031157 +name: regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:4338436] +synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED [] +synonym: "regulation of aggregation during fruiting body formation" RELATED [] +is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0031158 +name: negative regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:mtg_sensu, GOC:pg, PMID:5002049] +synonym: "down regulation of aggregate size" EXACT [] +synonym: "down-regulation of aggregate size" EXACT [] +synonym: "downregulation of aggregate size" EXACT [] +synonym: "inhibition of aggregate size" NARROW [] +is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development + +[Term] +id: GO:0031159 +name: positive regulation of aggregate size involved in sorocarp development +namespace: biological_process +def: "Any process that increases the size of the aggregate formed during sorocarp formation." [GOC:mah, GOC:pg, PMID:5002049] +synonym: "activation of aggregate size" NARROW [] +synonym: "stimulation of aggregate size" NARROW [] +synonym: "up regulation of aggregate size" EXACT [] +synonym: "up-regulation of aggregate size" EXACT [] +synonym: "upregulation of aggregate size" EXACT [] +is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development + +[Term] +id: GO:0031160 +name: spore wall +namespace: cellular_component +def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] +synonym: "spore coat" EXACT [] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0031161 +name: phosphatidylinositol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah] +synonym: "phosphatidylinositol breakdown" EXACT [] +synonym: "phosphatidylinositol catabolism" EXACT [] +synonym: "phosphatidylinositol degradation" EXACT [] +synonym: "PtdIns catabolic process" EXACT [] +synonym: "PtdIns catabolism" EXACT [] +is_a: GO:0046475 ! glycerophospholipid catabolic process +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:0031162 +name: sulfur incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] +synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0006790 ! sulfur compound metabolic process +relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly + +[Term] +id: GO:0031163 +name: metallo-sulfur cluster assembly +namespace: biological_process +def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] +synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr] +synonym: "metallo-sulfur cluster biosynthesis" RELATED [] +synonym: "metallo-sulphur cluster assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0031164 +name: contractile vacuolar membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] +synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf] +is_a: GO:0005774 ! vacuolar membrane +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0000331 ! contractile vacuole + +[Term] +id: GO:0031165 +name: integral component of contractile vacuolar membrane +namespace: cellular_component +def: "The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:pg] +synonym: "integral to contractile vacuolar membrane" EXACT [] +is_a: GO:0031166 ! integral component of vacuolar membrane +is_a: GO:0031311 ! intrinsic component of contractile vacuolar membrane + +[Term] +id: GO:0031166 +name: integral component of vacuolar membrane +namespace: cellular_component +def: "The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:mah] +synonym: "integral to vacuolar membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0031310 ! intrinsic component of vacuolar membrane + +[Term] +id: GO:0031167 +name: rRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] +is_a: GO:0000154 ! rRNA modification +is_a: GO:0001510 ! RNA methylation + +[Term] +id: GO:0031168 +name: ferrichrome metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] +synonym: "ferrichrome metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0009237 ! siderophore metabolic process + +[Term] +id: GO:0031169 +name: ferrichrome biosynthetic process +namespace: biological_process +alt_id: GO:0031199 +alt_id: GO:0031200 +def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] +synonym: "ferrichrome anabolism" EXACT [] +synonym: "ferrichrome biosynthesis" EXACT [] +synonym: "ferrichrome biosynthetic process, peptide formation" NARROW [] +synonym: "ferrichrome biosynthetic process, peptide modification" NARROW [] +synonym: "ferrichrome formation" EXACT [] +synonym: "ferrichrome synthesis" EXACT [] +is_a: GO:0019539 ! hydroxymate-containing siderophore biosynthetic process +is_a: GO:0031168 ! ferrichrome metabolic process + +[Term] +id: GO:0031170 +name: ferricrocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] +synonym: "ferricrocin metabolism" EXACT [] +is_a: GO:0031168 ! ferrichrome metabolic process + +[Term] +id: GO:0031171 +name: ferricrocin biosynthetic process +namespace: biological_process +alt_id: GO:0031185 +alt_id: GO:0031186 +def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] +synonym: "ferricrocin anabolism" EXACT [] +synonym: "ferricrocin biosynthesis" EXACT [] +synonym: "ferricrocin biosynthetic process, peptide formation" NARROW [] +synonym: "ferricrocin biosynthetic process, peptide modification" NARROW [] +synonym: "ferricrocin formation" EXACT [] +synonym: "ferricrocin synthesis" EXACT [] +is_a: GO:0031169 ! ferrichrome biosynthetic process +is_a: GO:0031170 ! ferricrocin metabolic process + +[Term] +id: GO:0031172 +name: ornithine N5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635] +synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128] +xref: MetaCyc:RXN-11128 +xref: RHEA:41508 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0031173 +name: otolith mineralization completed early in development +namespace: biological_process +def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] +synonym: "otoconia mineralization" EXACT [] +synonym: "otoconium mineralization" EXACT [] +is_a: GO:0045299 ! otolith mineralization + +[Term] +id: GO:0031174 +name: lifelong otolith mineralization +namespace: biological_process +def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873] +is_a: GO:0045299 ! otolith mineralization + +[Term] +id: GO:0031175 +name: neuron projection development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] +synonym: "neurite biosynthesis" NARROW [] +synonym: "neurite development" NARROW [GOC:dph] +synonym: "neurite formation" NARROW [] +synonym: "neurite growth" NARROW [] +synonym: "neurite outgrowth" NARROW [] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0031176 +name: endo-1,4-beta-xylanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] +synonym: "1,4-beta-D-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8] +synonym: "1,4-beta-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8] +synonym: "beta-1,4-xylan xylanohydrolase activity" RELATED [EC:3.2.1.8] +synonym: "beta-1,4-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "beta-D-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "beta-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity" RELATED [EC:3.2.1.8] +synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" RELATED [EC:3.2.1.8] +synonym: "endo-1,4-beta-D-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "endo-1,4-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "endo-beta-1,4-xylanase activity" RELATED [EC:3.2.1.8] +synonym: "xylanase" BROAD [EC:3.2.1.8] +xref: EC:3.2.1.8 +xref: MetaCyc:3.2.1.8-RXN +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0031177 +name: phosphopantetheine binding +namespace: molecular_function +def: "Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [GOC:mah, GOC:vw] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0033218 ! amide binding +is_a: GO:0072341 ! modified amino acid binding + +[Term] +id: GO:0031179 +name: peptide modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:0031201 +name: SNARE complex +namespace: cellular_component +def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031203 +name: posttranslational protein targeting to membrane, docking +namespace: biological_process +def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814] +synonym: "posttranslational protein membrane targeting, docking" EXACT [] +synonym: "protein docking during posttranslational protein targeting to membrane" EXACT [] +synonym: "Sec-translated protein complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane + +[Term] +id: GO:0031204 +name: posttranslational protein targeting to membrane, translocation +namespace: biological_process +def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] +synonym: "posttranslational protein membrane targeting, translocation" EXACT [] +synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT [] +is_a: GO:0065002 ! intracellular protein transmembrane transport +relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane + +[Term] +id: GO:0031205 +name: endoplasmic reticulum Sec complex +namespace: cellular_component +def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:14617809] +subset: goslim_pir +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0031207 +name: Sec62/Sec63 complex +namespace: cellular_component +def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] +synonym: "ER protein translocation subcomplex" EXACT [] +synonym: "Sec62/63 complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex + +[Term] +id: GO:0031208 +name: POZ domain binding +namespace: molecular_function +def: "Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] +synonym: "broad-complex, tramtrack, and bric-a-brac domain binding" EXACT [] +synonym: "BTB domain" EXACT [PMID:22621901] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0031209 +name: SCAR complex +namespace: cellular_component +def: "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101] +synonym: "WAVE complex" EXACT [] +synonym: "WAVE regulatory complex" EXACT [] +synonym: "WRC" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031210 +name: phosphatidylcholine binding +namespace: molecular_function +def: "Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0043169 ! cation binding +is_a: GO:0050997 ! quaternary ammonium group binding + +[Term] +id: GO:0031211 +name: endoplasmic reticulum palmitoyltransferase complex +namespace: cellular_component +def: "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1905961 ! protein-cysteine S-palmitoyltransferase complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031213 +name: RSF complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] +synonym: "remodeling and spacing factor complex" EXACT [] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0031214 +name: biomineral tissue development +namespace: biological_process +def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] +xref: Wikipedia:Biomineralization +is_a: GO:0009888 ! tissue development +is_a: GO:0110148 ! biomineralization +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0031215 +name: shell calcification +namespace: biological_process +def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736] +is_a: GO:0031214 ! biomineral tissue development + +[Term] +id: GO:0031216 +name: neopullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] +synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" RELATED [EC:3.2.1.135] +synonym: "pullulanase II activity" EXACT [] +xref: EC:3.2.1.135 +xref: MetaCyc:3.2.1.135-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0031217 +name: glucan 1,4-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] +synonym: "1,4-beta-D-glucan glucohydrolase activity" BROAD [EC:3.2.1.74] +synonym: "beta-1,4-beta-glucanase activity" BROAD [EC:3.2.1.74] +synonym: "beta-1,4-glucanase activity" BROAD [] +synonym: "exo-1,4-beta-D-glucosidase activity" RELATED [EC:3.2.1.74] +synonym: "exo-1,4-beta-glucanase activity" EXACT [] +synonym: "exo-1,4-beta-glucosidase activity" EXACT [] +synonym: "exo-beta-1,4-glucanase activity" EXACT [] +synonym: "exo-beta-1,4-glucosidase activity" EXACT [] +synonym: "exocellulase activity" EXACT [] +xref: EC:3.2.1.74 +xref: MetaCyc:3.2.1.74-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0031218 +name: arabinogalactan endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] +synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.89] +synonym: "arabinogalactanase activity" EXACT [] +synonym: "endo-1,4-beta-galactanase activity" EXACT [] +synonym: "galactanase activity" EXACT [] +xref: EC:3.2.1.89 +xref: MetaCyc:3.2.1.89-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0031219 +name: levanase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] +synonym: "2,6-beta-D-fructan fructanohydrolase activity" RELATED [EC:3.2.1.65] +synonym: "levan hydrolase activity" EXACT [] +xref: EC:3.2.1.65 +xref: MetaCyc:3.2.1.65-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0031220 +name: maltodextrin phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] +xref: MetaCyc:RXN-9025 +xref: MetaCyc:RXN0-5182 +xref: RHEA:29691 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0031221 +name: arabinan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] +synonym: "arabinan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0031222 +name: arabinan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] +synonym: "arabinan breakdown" EXACT [] +synonym: "arabinan catabolism" EXACT [] +synonym: "arabinan degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0031221 ! arabinan metabolic process + +[Term] +id: GO:0031223 +name: auditory behavior +namespace: biological_process +def: "The behavior of an organism in response to a sound." [GOC:pr, GOC:rc] +synonym: "auditory behaviour" EXACT [] +synonym: "behavioral response to sound" EXACT [] +synonym: "behavioural response to sound" EXACT [] +is_a: GO:0007638 ! mechanosensory behavior +relationship: part_of GO:0010996 ! response to auditory stimulus + +[Term] +id: GO:0031224 +name: intrinsic component of membrane +namespace: cellular_component +def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah] +comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. +subset: goslim_metagenomics +synonym: "intrinsic to membrane" NARROW [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0031225 +name: anchored component of membrane +namespace: cellular_component +def: "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] +synonym: "anchored to membrane" EXACT [] +is_a: GO:0031224 ! intrinsic component of membrane + +[Term] +id: GO:0031226 +name: intrinsic component of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to plasma membrane" NARROW [] +is_a: GO:0031224 ! intrinsic component of membrane +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0031227 +name: intrinsic component of endoplasmic reticulum membrane +namespace: cellular_component +def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to endoplasmic reticulum membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031228 +name: intrinsic component of Golgi membrane +namespace: cellular_component +def: "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to Golgi membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0000139 ! Golgi membrane + +[Term] +id: GO:0031229 +name: intrinsic component of nuclear inner membrane +namespace: cellular_component +def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to nuclear inner membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0005637 ! nuclear inner membrane + +[Term] +id: GO:0031230 +name: intrinsic component of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "intrinsic to cell outer membrane" NARROW [] +is_a: GO:0031224 ! intrinsic component of membrane +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031231 +name: intrinsic component of peroxisomal membrane +namespace: cellular_component +def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to peroxisomal membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0005778 ! peroxisomal membrane + +[Term] +id: GO:0031232 +name: extrinsic component of external side of plasma membrane +namespace: cellular_component +def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "extrinsic to external side of plasma membrane" NARROW [] +is_a: GO:0019897 ! extrinsic component of plasma membrane +relationship: part_of GO:0009897 ! external side of plasma membrane + +[Term] +id: GO:0031233 +name: intrinsic component of external side of plasma membrane +namespace: cellular_component +def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] +synonym: "intrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "intrinsic to external side of plasma membrane" NARROW [] +is_a: GO:0031226 ! intrinsic component of plasma membrane +relationship: part_of GO:0009897 ! external side of plasma membrane + +[Term] +id: GO:0031234 +name: extrinsic component of cytoplasmic side of plasma membrane +namespace: cellular_component +def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] +comment: Consider also annotating to 'cell cortex ; GO:0005938'. +synonym: "extrinsic to cytoplasmic side of plasma membrane" NARROW [] +synonym: "extrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "extrinsic to internal side of plasma membrane" EXACT [] +is_a: GO:0019897 ! extrinsic component of plasma membrane +relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane + +[Term] +id: GO:0031235 +name: intrinsic component of the cytoplasmic side of the plasma membrane +namespace: cellular_component +def: "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah] +synonym: "intrinsic to cytoplasmic side of plasma membrane" NARROW [] +synonym: "intrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "intrinsic to internal side of plasma membrane" EXACT [] +is_a: GO:0031226 ! intrinsic component of plasma membrane +relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane + +[Term] +id: GO:0031236 +name: extrinsic component of periplasmic side of plasma membrane +namespace: cellular_component +alt_id: GO:0031238 +def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "extrinsic to external leaflet of plasma membrane, in periplasmic space" NARROW [GOC:ab] +synonym: "extrinsic to external side of plasma membrane, in periplasmic space" NARROW [] +is_a: GO:0031232 ! extrinsic component of external side of plasma membrane +relationship: part_of GO:0098567 ! periplasmic side of plasma membrane + +[Term] +id: GO:0031237 +name: intrinsic component of periplasmic side of plasma membrane +namespace: cellular_component +alt_id: GO:0031239 +def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:mah, GOC:mtg_sensu] +synonym: "intrinsic to external leaflet of plasma membrane, in periplasmic space" EXACT [GOC:ab] +synonym: "intrinsic to periplasmic side of plasma membrane" EXACT [] +is_a: GO:0031233 ! intrinsic component of external side of plasma membrane +relationship: part_of GO:0098567 ! periplasmic side of plasma membrane + +[Term] +id: GO:0031240 +name: external side of cell outer membrane +namespace: cellular_component +def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] +comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. +synonym: "external leaflet of cell outer membrane" EXACT [GOC:ab] +synonym: "external side of outer membrane" RELATED [] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031241 +name: periplasmic side of cell outer membrane +namespace: cellular_component +def: "The side (leaflet) of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] +comment: In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane. +synonym: "internal leaflet of cell outer membrane" EXACT [GOC:ab] +synonym: "internal side of cell outer membrane" EXACT [] +synonym: "internal side of outer membrane" EXACT [] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031242 +name: extrinsic component of external side of cell outer membrane +namespace: cellular_component +def: "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "extrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] +synonym: "extrinsic to external side of cell outer membrane" NARROW [] +synonym: "extrinsic to external side of outer membrane" EXACT [] +is_a: GO:0031244 ! extrinsic component of cell outer membrane +relationship: part_of GO:0031240 ! external side of cell outer membrane + +[Term] +id: GO:0031243 +name: intrinsic component of external side of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "intrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] +synonym: "intrinsic to external side of cell outer membrane" NARROW [] +synonym: "intrinsic to external side of outer membrane" EXACT [] +is_a: GO:0031230 ! intrinsic component of cell outer membrane +relationship: part_of GO:0031240 ! external side of cell outer membrane + +[Term] +id: GO:0031244 +name: extrinsic component of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "extrinsic to cell outer membrane" NARROW [] +is_a: GO:0019898 ! extrinsic component of membrane +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0031245 +name: extrinsic component of periplasmic side of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "extrinsic to internal leaflet of cell outer membrane" NARROW [GOC:ab] +synonym: "extrinsic to internal side of cell outer membrane" EXACT [] +synonym: "extrinsic to internal side of outer membrane" EXACT [] +synonym: "extrinsic to periplasmic side of cell outer membrane" EXACT [] +is_a: GO:0031244 ! extrinsic component of cell outer membrane +relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane + +[Term] +id: GO:0031246 +name: intrinsic component of periplasmic side of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] +synonym: "intrinsic to external side of cell outer membrane" NARROW [] +synonym: "intrinsic to internal leaflet of cell outer membrane" EXACT [GOC:ab] +synonym: "intrinsic to internal side of cell outer membrane" EXACT [] +synonym: "intrinsic to internal side of outer membrane" EXACT [] +is_a: GO:0031230 ! intrinsic component of cell outer membrane +relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane + +[Term] +id: GO:0031247 +name: actin rod assembly +namespace: biological_process +def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699] +synonym: "actin rod formation" RELATED [GOC:mah] +is_a: GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0031248 +name: protein acetyltransferase complex +namespace: cellular_component +def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902493 ! acetyltransferase complex + +[Term] +id: GO:0031249 +name: denatured protein binding +namespace: molecular_function +def: "Binding to a denatured protein." [GOC:mlg] +comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031250 +name: anaerobic ribonucleoside-triphosphate reductase complex +namespace: cellular_component +def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031251 +name: PAN complex +namespace: cellular_component +def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] +synonym: "poly(A) nuclease complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031252 +name: cell leading edge +namespace: cellular_component +def: "The area of a motile cell closest to the direction of movement." [GOC:pg] +subset: goslim_pir +synonym: "front of cell" EXACT [] +synonym: "leading edge of cell" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0031253 +name: cell projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:krc, GOC:mah] +synonym: "membrane extension" RELATED [] +synonym: "membrane projection" RELATED [] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0031254 +name: cell trailing edge +namespace: cellular_component +def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] +subset: goslim_pir +synonym: "back of cell" EXACT [] +synonym: "trailing edge" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0031255 +name: lateral part of motile cell +namespace: cellular_component +def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg, GOC:pr] +is_a: GO:0097574 ! lateral part of cell + +[Term] +id: GO:0031256 +name: leading edge membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0031257 +name: cell trailing edge membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] +synonym: "trailing edge membrane" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0031254 ! cell trailing edge + +[Term] +id: GO:0031258 +name: lamellipodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0030027 ! lamellipodium + +[Term] +id: GO:0031259 +name: uropod membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] +synonym: "uropodium membrane" EXACT [] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031257 ! cell trailing edge membrane +relationship: part_of GO:0001931 ! uropod + +[Term] +id: GO:0031260 +name: pseudopodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0031143 ! pseudopodium + +[Term] +id: GO:0031261 +name: DNA replication preinitiation complex +namespace: cellular_component +def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] +synonym: "pre-IC" EXACT [] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0031262 +name: Ndc80 complex +namespace: cellular_component +def: "An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25." [GOC:krc, GOC:vw, PMID:15509863, PMID:15661517, PMID:28502666] +synonym: "Nuf2-Ndc80 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0031617 ! NMS complex + +[Term] +id: GO:0031263 +name: obsolete ATPase-coupled amine transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] +comment: This term was obsoleted because it corresponds to a wide range of substrates not necessarily transported by the same transporter. See https://en.wikipedia.org/wiki/Amine. +synonym: "amine ABC transporter" NARROW [] +synonym: "amine-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent amine transporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031264 +name: death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815] +comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. +subset: goslim_pir +synonym: "death receptor-induced signaling complex" EXACT [] +synonym: "death receptor-induced signalling complex" EXACT [] +synonym: "death-inducing signalling complex" EXACT [] +synonym: "DISC" EXACT [] +synonym: "DISC protein complex" EXACT [] +xref: Wikipedia:Death-inducing_signaling_complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0031265 +name: CD95 death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] +synonym: "CD95 death-inducing signalling complex" EXACT [] +synonym: "CD95 DISC" EXACT [] +synonym: "Fas death-inducing signaling complex" EXACT [] +is_a: GO:0031264 ! death-inducing signaling complex + +[Term] +id: GO:0031266 +name: TRAIL death-inducing signaling complex +namespace: cellular_component +def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] +synonym: "TRAIL death-inducing signalling complex" EXACT [] +synonym: "TRAIL DISC" EXACT [] +is_a: GO:0031264 ! death-inducing signaling complex + +[Term] +id: GO:0031267 +name: small GTPase binding +namespace: molecular_function +alt_id: GO:0005084 +alt_id: GO:0008536 +alt_id: GO:0017016 +alt_id: GO:0017031 +alt_id: GO:0017048 +alt_id: GO:0017049 +alt_id: GO:0017137 +alt_id: GO:0017160 +alt_id: GO:0030306 +alt_id: GO:0034989 +alt_id: GO:0048365 +def: "Binding to a small monomeric GTPase." [GOC:mah, PMID:27218782] +synonym: "ADP-ribosylation factor binding" NARROW [] +synonym: "ARF binding" NARROW [] +synonym: "GTP-Ral binding" NARROW [] +synonym: "GTP-Rho binding" NARROW [] +synonym: "Rab escort protein activity" NARROW [] +synonym: "Rab GTPase binding" NARROW [] +synonym: "Rab interactor activity" NARROW [] +synonym: "Rac GTPase binding" NARROW [] +synonym: "Ral GTPase binding" NARROW [] +synonym: "Ran GTPase binding" NARROW [] +synonym: "Ran protein binding" NARROW [] +synonym: "Ran-binding protein" NARROW [] +synonym: "Ras GTPase binding" NARROW [] +synonym: "Ras interactor activity" NARROW [] +synonym: "REP" NARROW [] +synonym: "Rho GTPase binding" NARROW [] +is_a: GO:0051020 ! GTPase binding + +[Term] +id: GO:0031268 +name: pseudopodium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] +synonym: "pseudopodium organisation" EXACT [] +synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0031269 +name: pseudopodium assembly +namespace: biological_process +def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] +synonym: "pseudopodium extension" EXACT [] +synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0031268 ! pseudopodium organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0031270 +name: pseudopodium retraction +namespace: biological_process +def: "The myosin-based contraction and retraction of a pseudopodium." [GOC:pg] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0031268 ! pseudopodium organization + +[Term] +id: GO:0031271 +name: lateral pseudopodium assembly +namespace: biological_process +def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] +synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0031269 ! pseudopodium assembly + +[Term] +id: GO:0031272 +name: regulation of pseudopodium assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +synonym: "regulation of pseudopodium formation" RELATED [] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0031269 ! pseudopodium assembly + +[Term] +id: GO:0031273 +name: negative regulation of pseudopodium assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +synonym: "down regulation of pseudopodium formation" RELATED [] +synonym: "down-regulation of pseudopodium formation" RELATED [] +synonym: "downregulation of pseudopodium formation" RELATED [] +synonym: "inhibition of pseudopodium formation" NARROW [] +synonym: "negative regulation of pseudopodium formation" RELATED [] +is_a: GO:0031272 ! regulation of pseudopodium assembly +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +relationship: negatively_regulates GO:0031269 ! pseudopodium assembly + +[Term] +id: GO:0031274 +name: positive regulation of pseudopodium assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] +synonym: "activation of pseudopodium formation" NARROW [] +synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] +synonym: "stimulation of pseudopodium formation" NARROW [] +synonym: "up regulation of pseudopodium formation" RELATED [] +synonym: "up-regulation of pseudopodium formation" RELATED [] +synonym: "upregulation of pseudopodium formation" RELATED [] +is_a: GO:0031272 ! regulation of pseudopodium assembly +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +relationship: positively_regulates GO:0031269 ! pseudopodium assembly + +[Term] +id: GO:0031275 +name: obsolete regulation of lateral pseudopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] +comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction. +synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0031276 +name: obsolete negative regulation of lateral pseudopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] +comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction. +synonym: "down regulation of lateral pseudopodium formation" RELATED [] +synonym: "down-regulation of lateral pseudopodium formation" RELATED [] +synonym: "downregulation of lateral pseudopodium formation" RELATED [] +synonym: "inhibition of lateral pseudopodium formation" NARROW [] +synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph] +is_obsolete: true +replaced_by: GO:0120320 + +[Term] +id: GO:0031277 +name: obsolete positive regulation of lateral pseudopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] +comment: The regulation of lateral pseudopodium assembly terms were not used consistently. The negative regulation term has been replaced by GO:0120320 lateral pseudopodium retraction. +synonym: "activation of lateral pseudopodium formation" NARROW [] +synonym: "positive regulation of lateral pseudopodium formation" RELATED [] +synonym: "stimulation of lateral pseudopodium formation" NARROW [] +synonym: "up regulation of lateral pseudopodium formation" RELATED [] +synonym: "up-regulation of lateral pseudopodium formation" RELATED [] +synonym: "upregulation of lateral pseudopodium formation" RELATED [] +is_obsolete: true + +[Term] +id: GO:0031278 +name: alpha-1,2-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0031279 +name: regulation of cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0031280 +name: negative regulation of cyclase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah] +synonym: "down regulation of cyclase activity" EXACT [] +synonym: "down-regulation of cyclase activity" EXACT [] +synonym: "downregulation of cyclase activity" EXACT [] +synonym: "inhibition of cyclase activity" NARROW [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0031281 +name: positive regulation of cyclase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a cyclase." [GOC:mah] +synonym: "activation of cyclase activity" NARROW [] +synonym: "stimulation of cyclase activity" NARROW [] +synonym: "up regulation of cyclase activity" EXACT [] +synonym: "up-regulation of cyclase activity" EXACT [] +synonym: "upregulation of cyclase activity" EXACT [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0043085 ! positive regulation of catalytic activity + +[Term] +id: GO:0031282 +name: regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0051339 ! regulation of lyase activity +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process + +[Term] +id: GO:0031283 +name: negative regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +synonym: "down regulation of guanylate cyclase activity" EXACT [] +synonym: "down-regulation of guanylate cyclase activity" EXACT [] +synonym: "downregulation of guanylate cyclase activity" EXACT [] +synonym: "inhibition of guanylate cyclase activity" NARROW [] +is_a: GO:0031280 ! negative regulation of cyclase activity +is_a: GO:0031282 ! regulation of guanylate cyclase activity +is_a: GO:0051350 ! negative regulation of lyase activity +is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process + +[Term] +id: GO:0031284 +name: positive regulation of guanylate cyclase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] +synonym: "activation of guanylate cyclase activity" NARROW [] +synonym: "stimulation of guanylate cyclase activity" NARROW [] +synonym: "up regulation of guanylate cyclase activity" EXACT [] +synonym: "up-regulation of guanylate cyclase activity" EXACT [] +synonym: "upregulation of guanylate cyclase activity" EXACT [] +is_a: GO:0031281 ! positive regulation of cyclase activity +is_a: GO:0031282 ! regulation of guanylate cyclase activity +is_a: GO:0051349 ! positive regulation of lyase activity +is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process + +[Term] +id: GO:0031285 +name: regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] +synonym: "regulation of stalk cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031286 +name: negative regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] +synonym: "down regulation of stalk cell differentiation" EXACT [] +synonym: "down-regulation of stalk cell differentiation" EXACT [] +synonym: "downregulation of stalk cell differentiation" EXACT [] +synonym: "inhibition of stalk cell differentiation" NARROW [] +synonym: "negative regulation of stalk cell differentiation" EXACT [] +is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031287 +name: positive regulation of sorocarp stalk cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4338436] +synonym: "activation of stalk cell differentiation" NARROW [] +synonym: "positive regulation of stalk cell differentiation" EXACT [] +synonym: "stimulation of stalk cell differentiation" NARROW [] +synonym: "up regulation of stalk cell differentiation" EXACT [] +synonym: "up-regulation of stalk cell differentiation" EXACT [] +synonym: "upregulation of stalk cell differentiation" EXACT [] +is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation + +[Term] +id: GO:0031288 +name: sorocarp morphogenesis +namespace: biological_process +def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [GOC:kp, GOC:mtg_sensu, PMID:4332228] +synonym: "fruiting body morphogenesis" BROAD [DDANAT:0000012] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030587 ! sorocarp development + +[Term] +id: GO:0031289 +name: actin phosphorylation +namespace: biological_process +def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah] +is_a: GO:0006468 ! protein phosphorylation +is_a: GO:0030047 ! actin modification + +[Term] +id: GO:0031290 +name: retinal ganglion cell axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] +synonym: "retinal ganglion cell axon pathfinding" EXACT [] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0031291 +name: Ran protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0031293 +name: membrane protein intracellular domain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018] +synonym: "membrane protein solubilization" RELATED [] +is_a: GO:0033619 ! membrane protein proteolysis + +[Term] +id: GO:0031294 +name: lymphocyte costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149] +synonym: "lymphocyte co-stimulation" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0051251 ! positive regulation of lymphocyte activation + +[Term] +id: GO:0031295 +name: T cell costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149] +synonym: "T cell co-stimulation" EXACT [] +synonym: "T lymphocyte costimulation" EXACT [] +synonym: "T-cell co-stimulation" EXACT [] +synonym: "T-cell costimulation" EXACT [] +synonym: "T-lymphocyte costimulation" EXACT [] +is_a: GO:0031294 ! lymphocyte costimulation +is_a: GO:0050870 ! positive regulation of T cell activation + +[Term] +id: GO:0031296 +name: B cell costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149] +synonym: "B cell co-stimulation" EXACT [] +synonym: "B lymphocyte co-stimulation" EXACT [] +synonym: "B lymphocyte costimulation" EXACT [] +synonym: "B-cell co-stimulation" EXACT [] +synonym: "B-cell costimulation" EXACT [] +synonym: "B-lymphocyte co-stimulation" EXACT [] +synonym: "B-lymphocyte costimulation" EXACT [] +is_a: GO:0031294 ! lymphocyte costimulation +is_a: GO:0050871 ! positive regulation of B cell activation + +[Term] +id: GO:0031297 +name: replication fork processing +namespace: biological_process +alt_id: GO:0034065 +def: "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] +synonym: "collapsed replication fork processing" EXACT [] +synonym: "recovery from replication fork arrest" EXACT [] +synonym: "recovery from replication fork arrest at rDNA locus" NARROW [] +synonym: "recovery from replication fork stalling" EXACT [] +synonym: "recovery from replication fork stalling at rDNA locus" NARROW [] +synonym: "replication fork processing at rDNA locus" NARROW [] +synonym: "replication fork processing at ribosomal DNA locus" NARROW [] +synonym: "replication fork restart" RELATED [PMID:20842177] +synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929] +is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity + +[Term] +id: GO:0031298 +name: replication fork protection complex +namespace: cellular_component +def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] +synonym: "replisome progression complex" EXACT [GOC:vw] +synonym: "Swi1-Swi3 complex" NARROW [] +synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043596 ! nuclear replication fork + +[Term] +id: GO:0031299 +name: taurine-pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [EC:2.6.1.77, RHEA:10420] +synonym: "taurine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.77] +synonym: "Tpa" RELATED [EC:2.6.1.77] +xref: EC:2.6.1.77 +xref: KEGG_REACTION:R05652 +xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN +xref: RHEA:10420 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0031300 +name: intrinsic component of organelle membrane +namespace: cellular_component +def: "The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to organelle membrane" NARROW [] +is_a: GO:0031224 ! intrinsic component of membrane +relationship: part_of GO:0031090 ! organelle membrane + +[Term] +id: GO:0031301 +name: integral component of organelle membrane +namespace: cellular_component +def: "The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to organelle membrane" EXACT [] +is_a: GO:0016021 ! integral component of membrane +is_a: GO:0031300 ! intrinsic component of organelle membrane + +[Term] +id: GO:0031302 +name: intrinsic component of endosome membrane +namespace: cellular_component +def: "The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to endosome membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0031303 +name: integral component of endosome membrane +namespace: cellular_component +def: "The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to endosome membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0031302 ! intrinsic component of endosome membrane + +[Term] +id: GO:0031304 +name: intrinsic component of mitochondrial inner membrane +namespace: cellular_component +def: "The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to mitochondrial inner membrane" NARROW [] +is_a: GO:0098573 ! intrinsic component of mitochondrial membrane +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0031305 +name: integral component of mitochondrial inner membrane +namespace: cellular_component +def: "The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to mitochondrial inner membrane" EXACT [] +is_a: GO:0031304 ! intrinsic component of mitochondrial inner membrane +is_a: GO:0032592 ! integral component of mitochondrial membrane + +[Term] +id: GO:0031306 +name: intrinsic component of mitochondrial outer membrane +namespace: cellular_component +def: "The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to mitochondrial outer membrane" NARROW [] +is_a: GO:0098573 ! intrinsic component of mitochondrial membrane +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0031307 +name: integral component of mitochondrial outer membrane +namespace: cellular_component +def: "The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to mitochondrial outer membrane" NARROW [] +is_a: GO:0031306 ! intrinsic component of mitochondrial outer membrane +is_a: GO:0032592 ! integral component of mitochondrial membrane + +[Term] +id: GO:0031308 +name: intrinsic component of nuclear outer membrane +namespace: cellular_component +def: "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to nuclear outer membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0005640 ! nuclear outer membrane + +[Term] +id: GO:0031309 +name: integral component of nuclear outer membrane +namespace: cellular_component +def: "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to nuclear outer membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0031308 ! intrinsic component of nuclear outer membrane + +[Term] +id: GO:0031310 +name: intrinsic component of vacuolar membrane +namespace: cellular_component +def: "The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to vacuolar membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0031311 +name: intrinsic component of contractile vacuolar membrane +namespace: cellular_component +def: "The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to contractile vacuolar membrane" NARROW [] +is_a: GO:0031310 ! intrinsic component of vacuolar membrane +relationship: part_of GO:0031164 ! contractile vacuolar membrane + +[Term] +id: GO:0031312 +name: extrinsic component of organelle membrane +namespace: cellular_component +def: "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to organelle membrane" NARROW [] +is_a: GO:0019898 ! extrinsic component of membrane +relationship: part_of GO:0031090 ! organelle membrane +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0031313 +name: extrinsic component of endosome membrane +namespace: cellular_component +def: "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to endosome membrane" NARROW [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0031314 +name: extrinsic component of mitochondrial inner membrane +namespace: cellular_component +def: "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to mitochondrial inner membrane" NARROW [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0031315 +name: extrinsic component of mitochondrial outer membrane +namespace: cellular_component +def: "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to mitochondrial outer membrane" NARROW [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0031316 +name: extrinsic component of nuclear outer membrane +namespace: cellular_component +def: "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to nuclear outer membrane" NARROW [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005640 ! nuclear outer membrane + +[Term] +id: GO:0031317 +name: tripartite ATP-independent periplasmic transporter complex +namespace: cellular_component +def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg] +synonym: "TRAP transporter complex" EXACT [] +synonym: "TRAP-T transporter complex" EXACT [] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:0031318 +name: detection of folic acid +namespace: biological_process +def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg] +synonym: "detection of folate" EXACT [] +synonym: "folate detection" EXACT [] +synonym: "folate sensing" EXACT [] +synonym: "folic acid detection" EXACT [] +synonym: "folic acid sensing" EXACT [] +is_a: GO:0009594 ! detection of nutrient +is_a: GO:0051593 ! response to folic acid + +[Term] +id: GO:0031319 +name: detection of cAMP +namespace: biological_process +def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg] +synonym: "3',5'-cAMP detection" EXACT [] +synonym: "3',5'-cAMP sensing" EXACT [] +synonym: "cAMP detection" EXACT [] +synonym: "cAMP sensing" EXACT [] +synonym: "cyclic AMP detection" EXACT [] +synonym: "detection of 3',5' cAMP" EXACT [] +synonym: "detection of 3',5'-cAMP" EXACT [] +synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "detection of cyclic AMP" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051591 ! response to cAMP + +[Term] +id: GO:0031320 +name: hexitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0031321 +name: ascospore-type prospore assembly +namespace: biological_process +def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] +synonym: "ascospore-type prospore formation" EXACT [] +synonym: "forespore formation" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0030437 ! ascospore formation + +[Term] +id: GO:0031322 +name: ascospore-type prospore-specific spindle pole body remodeling +namespace: biological_process +def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] +synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw] +synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah] +synonym: "forespore specific spindle pole body remodeling" EXACT [] +synonym: "forespore-specific spindle pole body remodeling" EXACT [] +synonym: "prospore-specific spindle pole body remodeling" EXACT [] +synonym: "sporulation-specific spindle pole body remodeling" EXACT [] +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0031321 ! ascospore-type prospore assembly + +[Term] +id: GO:0031323 +name: regulation of cellular metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "regulation of cellular metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031324 +name: negative regulation of cellular metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "down regulation of cellular metabolic process" EXACT [] +synonym: "down-regulation of cellular metabolic process" EXACT [] +synonym: "downregulation of cellular metabolic process" EXACT [] +synonym: "inhibition of cellular metabolic process" NARROW [] +synonym: "negative regulation of cellular metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031325 +name: positive regulation of cellular metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "activation of cellular metabolic process" NARROW [] +synonym: "positive regulation of cellular metabolism" EXACT [] +synonym: "stimulation of cellular metabolic process" NARROW [] +synonym: "up regulation of cellular metabolic process" EXACT [] +synonym: "up-regulation of cellular metabolic process" EXACT [] +synonym: "upregulation of cellular metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0031326 +name: regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +synonym: "regulation of cellular anabolism" EXACT [] +synonym: "regulation of cellular biosynthesis" EXACT [] +synonym: "regulation of cellular formation" EXACT [] +synonym: "regulation of cellular synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031327 +name: negative regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +synonym: "down regulation of cellular biosynthetic process" EXACT [] +synonym: "down-regulation of cellular biosynthetic process" EXACT [] +synonym: "downregulation of cellular biosynthetic process" EXACT [] +synonym: "inhibition of cellular biosynthetic process" NARROW [] +synonym: "negative regulation of cellular anabolism" EXACT [] +synonym: "negative regulation of cellular biosynthesis" EXACT [] +synonym: "negative regulation of cellular formation" EXACT [] +synonym: "negative regulation of cellular synthesis" EXACT [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031328 +name: positive regulation of cellular biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] +synonym: "activation of cellular biosynthetic process" NARROW [] +synonym: "positive regulation of cellular anabolism" EXACT [] +synonym: "positive regulation of cellular biosynthesis" EXACT [] +synonym: "positive regulation of cellular formation" EXACT [] +synonym: "positive regulation of cellular synthesis" EXACT [] +synonym: "stimulation of cellular biosynthetic process" NARROW [] +synonym: "up regulation of cellular biosynthetic process" EXACT [] +synonym: "up-regulation of cellular biosynthetic process" EXACT [] +synonym: "upregulation of cellular biosynthetic process" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: positively_regulates GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0031329 +name: regulation of cellular catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +synonym: "regulation of cellular breakdown" EXACT [] +synonym: "regulation of cellular catabolism" EXACT [] +synonym: "regulation of cellular degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031330 +name: negative regulation of cellular catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +synonym: "down regulation of cellular catabolic process" EXACT [] +synonym: "down-regulation of cellular catabolic process" EXACT [] +synonym: "downregulation of cellular catabolic process" EXACT [] +synonym: "inhibition of cellular catabolic process" NARROW [] +synonym: "negative regulation of cellular breakdown" EXACT [] +synonym: "negative regulation of cellular catabolism" EXACT [] +synonym: "negative regulation of cellular degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: negatively_regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031331 +name: positive regulation of cellular catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] +synonym: "activation of cellular catabolic process" NARROW [] +synonym: "positive regulation of cellular breakdown" EXACT [] +synonym: "positive regulation of cellular catabolism" EXACT [] +synonym: "positive regulation of cellular degradation" EXACT [] +synonym: "stimulation of cellular catabolic process" NARROW [] +synonym: "up regulation of cellular catabolic process" EXACT [] +synonym: "up-regulation of cellular catabolic process" EXACT [] +synonym: "upregulation of cellular catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: positively_regulates GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0031332 +name: RNAi effector complex +namespace: cellular_component +def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] +subset: goslim_pir +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0031333 +name: negative regulation of protein-containing complex assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] +synonym: "down regulation of protein complex assembly" EXACT [] +synonym: "down-regulation of protein complex assembly" EXACT [] +synonym: "downregulation of protein complex assembly" EXACT [] +synonym: "inhibition of protein complex assembly" NARROW [] +synonym: "negative regulation of protein complex assembly" RELATED [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0031334 +name: positive regulation of protein-containing complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] +synonym: "activation of protein complex assembly" NARROW [] +synonym: "positive regulation of protein complex assembly" RELATED [] +synonym: "stimulation of protein complex assembly" NARROW [] +synonym: "up regulation of protein complex assembly" EXACT [] +synonym: "up-regulation of protein complex assembly" EXACT [] +synonym: "upregulation of protein complex assembly" EXACT [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0031335 +name: regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +synonym: "regulation of sulfur amino acid metabolism" EXACT [] +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031336 +name: negative regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +synonym: "down regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "down-regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "downregulation of sulfur amino acid metabolic process" EXACT [] +synonym: "inhibition of sulfur amino acid metabolic process" NARROW [] +synonym: "negative regulation of sulfur amino acid metabolism" EXACT [] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031337 +name: positive regulation of sulfur amino acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] +synonym: "activation of sulfur amino acid metabolic process" NARROW [] +synonym: "positive regulation of sulfur amino acid metabolism" EXACT [] +synonym: "stimulation of sulfur amino acid metabolic process" NARROW [] +synonym: "up regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "up-regulation of sulfur amino acid metabolic process" EXACT [] +synonym: "upregulation of sulfur amino acid metabolic process" EXACT [] +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process + +[Term] +id: GO:0031338 +name: regulation of vesicle fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031339 +name: negative regulation of vesicle fusion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] +synonym: "down regulation of vesicle fusion" EXACT [] +synonym: "down-regulation of vesicle fusion" EXACT [] +synonym: "downregulation of vesicle fusion" EXACT [] +synonym: "inhibition of vesicle fusion" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031340 +name: positive regulation of vesicle fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] +synonym: "activation of vesicle fusion" NARROW [] +synonym: "stimulation of vesicle fusion" NARROW [] +synonym: "up regulation of vesicle fusion" EXACT [] +synonym: "up-regulation of vesicle fusion" EXACT [] +synonym: "upregulation of vesicle fusion" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006906 ! vesicle fusion + +[Term] +id: GO:0031341 +name: regulation of cell killing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031342 +name: negative regulation of cell killing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] +synonym: "down regulation of cell killing" EXACT [] +synonym: "down-regulation of cell killing" EXACT [] +synonym: "downregulation of cell killing" EXACT [] +synonym: "inhibition of cell killing" NARROW [] +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031343 +name: positive regulation of cell killing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] +synonym: "activation of cell killing" NARROW [] +synonym: "stimulation of cell killing" NARROW [] +synonym: "up regulation of cell killing" EXACT [] +synonym: "up-regulation of cell killing" EXACT [] +synonym: "upregulation of cell killing" EXACT [] +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0001906 ! cell killing + +[Term] +id: GO:0031344 +name: regulation of cell projection organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +synonym: "regulation of cell projection organisation" EXACT [] +synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031345 +name: negative regulation of cell projection organization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +synonym: "down regulation of cell projection organization" EXACT [GOC:mah] +synonym: "down-regulation of cell projection organization" EXACT [] +synonym: "downregulation of cell projection organization" EXACT [] +synonym: "inhibition of cell projection organization" NARROW [] +synonym: "negative regulation of cell projection organisation" EXACT [] +synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031346 +name: positive regulation of cell projection organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] +synonym: "activation of cell projection organization" NARROW [] +synonym: "positive regulation of cell projection organisation" EXACT [] +synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] +synonym: "stimulation of cell projection organization" NARROW [] +synonym: "up regulation of cell projection organization" EXACT [] +synonym: "up-regulation of cell projection organization" EXACT [] +synonym: "upregulation of cell projection organization" EXACT [] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0030030 ! cell projection organization + +[Term] +id: GO:0031347 +name: regulation of defense response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0006952 ! defense response + +[Term] +id: GO:0031348 +name: negative regulation of defense response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] +synonym: "down regulation of defense response" EXACT [] +synonym: "down-regulation of defense response" EXACT [] +synonym: "downregulation of defense response" EXACT [] +synonym: "inhibition of defense response" NARROW [] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0006952 ! defense response + +[Term] +id: GO:0031349 +name: positive regulation of defense response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] +synonym: "activation of defense response" NARROW [] +synonym: "stimulation of defense response" NARROW [] +synonym: "up regulation of defense response" EXACT [] +synonym: "up-regulation of defense response" EXACT [] +synonym: "upregulation of defense response" EXACT [] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0006952 ! defense response + +[Term] +id: GO:0031350 +name: intrinsic component of plastid membrane +namespace: cellular_component +def: "The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to plastid membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0042170 ! plastid membrane + +[Term] +id: GO:0031351 +name: integral component of plastid membrane +namespace: cellular_component +def: "The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to plastid membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0031350 ! intrinsic component of plastid membrane + +[Term] +id: GO:0031352 +name: intrinsic component of plastid inner membrane +namespace: cellular_component +def: "The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to plastid inner membrane" NARROW [] +is_a: GO:0031350 ! intrinsic component of plastid membrane +relationship: part_of GO:0009528 ! plastid inner membrane + +[Term] +id: GO:0031353 +name: integral component of plastid inner membrane +namespace: cellular_component +def: "The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to plastid inner membrane" NARROW [] +is_a: GO:0031351 ! integral component of plastid membrane +is_a: GO:0031352 ! intrinsic component of plastid inner membrane + +[Term] +id: GO:0031354 +name: intrinsic component of plastid outer membrane +namespace: cellular_component +def: "The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to plastid outer membrane" NARROW [] +is_a: GO:0031350 ! intrinsic component of plastid membrane +relationship: part_of GO:0009527 ! plastid outer membrane + +[Term] +id: GO:0031355 +name: integral component of plastid outer membrane +namespace: cellular_component +def: "The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to plastid outer membrane" NARROW [] +is_a: GO:0031351 ! integral component of plastid membrane +is_a: GO:0031354 ! intrinsic component of plastid outer membrane + +[Term] +id: GO:0031356 +name: intrinsic component of chloroplast inner membrane +namespace: cellular_component +def: "The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to chloroplast inner membrane" NARROW [] +is_a: GO:0031352 ! intrinsic component of plastid inner membrane +relationship: part_of GO:0009706 ! chloroplast inner membrane + +[Term] +id: GO:0031357 +name: integral component of chloroplast inner membrane +namespace: cellular_component +def: "The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to chloroplast inner membrane" NARROW [] +is_a: GO:0031353 ! integral component of plastid inner membrane +is_a: GO:0031356 ! intrinsic component of chloroplast inner membrane + +[Term] +id: GO:0031358 +name: intrinsic component of chloroplast outer membrane +namespace: cellular_component +def: "The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to chloroplast outer membrane" NARROW [] +is_a: GO:0031354 ! intrinsic component of plastid outer membrane +relationship: part_of GO:0009707 ! chloroplast outer membrane + +[Term] +id: GO:0031359 +name: integral component of chloroplast outer membrane +namespace: cellular_component +def: "The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to chloroplast outer membrane" NARROW [] +is_a: GO:0031355 ! integral component of plastid outer membrane +is_a: GO:0031358 ! intrinsic component of chloroplast outer membrane + +[Term] +id: GO:0031360 +name: intrinsic component of thylakoid membrane +namespace: cellular_component +def: "The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to thylakoid membrane" NARROW [] +is_a: GO:0031224 ! intrinsic component of membrane +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0031361 +name: integral component of thylakoid membrane +namespace: cellular_component +def: "The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to thylakoid membrane" NARROW [] +is_a: GO:0016021 ! integral component of membrane +is_a: GO:0031360 ! intrinsic component of thylakoid membrane + +[Term] +id: GO:0031362 +name: anchored component of external side of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] +synonym: "anchored to external leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "anchored to external side of plasma membrane" EXACT [] +is_a: GO:0031233 ! intrinsic component of external side of plasma membrane +is_a: GO:0046658 ! anchored component of plasma membrane + +[Term] +id: GO:0031363 +name: N-terminal protein amino acid deamination +namespace: biological_process +def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah] +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0031364 +name: N-terminal protein amino acid deamination, from side chain +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah] +is_a: GO:0031363 ! N-terminal protein amino acid deamination + +[Term] +id: GO:0031365 +name: N-terminal protein amino acid modification +namespace: biological_process +alt_id: GO:0018409 +def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah] +synonym: "peptide or protein amino-terminal blocking" RELATED [] +synonym: "peptide/protein amino-terminal blocking" RELATED [] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0031366 +name: N-terminal peptidyl-asparagine deamination +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah] +is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain + +[Term] +id: GO:0031367 +name: N-terminal peptidyl-glutamine deamination +namespace: biological_process +def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah] +is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain + +[Term] +id: GO:0031368 +name: obsolete Pro-X metallocarboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] +synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] +synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] +synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] +synonym: "Pro-X metallocarboxypeptidase activity" EXACT [] +xref: EC:3.4.17.16 +is_obsolete: true +consider: GO:0004181 +consider: GO:0008233 + +[Term] +id: GO:0031369 +name: translation initiation factor binding +namespace: molecular_function +def: "Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031370 +name: eukaryotic initiation factor 4G binding +namespace: molecular_function +def: "Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] +synonym: "eIF4G binding" EXACT [] +is_a: GO:0031369 ! translation initiation factor binding + +[Term] +id: GO:0031371 +name: ubiquitin conjugating enzyme complex +namespace: cellular_component +def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] +subset: goslim_pir +synonym: "E2 complex" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0031372 +name: UBC13-MMS2 complex +namespace: cellular_component +def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex + +[Term] +id: GO:0031375 +name: obsolete type II fatty acid synthase complex +namespace: cellular_component +def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] +comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not. +synonym: "type II FAS" EXACT [] +synonym: "type II FAS complex" EXACT [] +synonym: "type II fatty acid synthase" EXACT [] +synonym: "type II fatty acid synthase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031376 +name: obsolete cytosolic type II fatty acid synthase complex +namespace: cellular_component +def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] +synonym: "cytosolic type II FAS complex" EXACT [] +synonym: "cytosolic type II fatty acid synthase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031377 +name: obsolete mitochondrial type II fatty acid synthase complex +namespace: cellular_component +def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] +comment: Obsoleted because type II fatty acid synthases are not complexes +synonym: "mitochondrial type II FAS complex" EXACT [] +synonym: "mitochondrial type II fatty acid synthase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031378 +name: obsolete plastid type II fatty acid synthase complex +namespace: cellular_component +def: "OBSOLETE. A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] +comment: Obsoleted because type II fatty acid synthase is not a complex. +synonym: "plastid type II FAS complex" EXACT [] +synonym: "plastid type II fatty acid synthase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031379 +name: RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] +is_a: GO:0030880 ! RNA polymerase complex + +[Term] +id: GO:0031380 +name: nuclear RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] +synonym: "Rdr1 complex" NARROW [] +synonym: "RDRC" EXACT [] +is_a: GO:0031379 ! RNA-directed RNA polymerase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0031381 +name: viral RNA-directed RNA polymerase complex +namespace: cellular_component +def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] +is_a: GO:0031379 ! RNA-directed RNA polymerase complex + +[Term] +id: GO:0031382 +name: mating projection formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532] +synonym: "mating projection assembly" EXACT [] +synonym: "mating projection biogenesis" RELATED [GOC:mah] +synonym: "shmooing" NARROW [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly +relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion + +[Term] +id: GO:0031383 +name: regulation of mating projection assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532] +synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0031382 ! mating projection formation + +[Term] +id: GO:0031384 +name: regulation of initiation of mating projection growth +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532] +is_a: GO:0031383 ! regulation of mating projection assembly + +[Term] +id: GO:0031385 +name: regulation of termination of mating projection growth +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532] +is_a: GO:0031383 ! regulation of mating projection assembly + +[Term] +id: GO:0031386 +name: protein tag +namespace: molecular_function +def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, GOC:go_curators, PMID:19028679, PMID:20054389, PMID:6305978] +comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures. +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +synonym: "covalent modifier" RELATED [GOC:vw] +synonym: "protein tagging activity" RELATED [] +synonym: "ubiquitin" RELATED [] +synonym: "ubiquitin-like protein modifier" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0031387 +name: MPF complex +namespace: cellular_component +def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0031388 +name: organic acid phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0031389 +name: Rad17 RFC-like complex +namespace: cellular_component +def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] +synonym: "Rad17-RFC" EXACT [] +synonym: "Rad17-RLC" EXACT [] +synonym: "Rad24p RFC-like complex" EXACT [] +synonym: "RFC (Rad17)" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0031390 +name: Ctf18 RFC-like complex +namespace: cellular_component +def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] +synonym: "Ctf18-RFC" EXACT [] +synonym: "Ctf18-RLC" EXACT [] +synonym: "RFC (Ctf18)" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0031391 +name: Elg1 RFC-like complex +namespace: cellular_component +def: "A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980] +synonym: "Elg1-RFC" EXACT [] +synonym: "Elg1-RLC" EXACT [] +synonym: "RFC (Elg1)" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0031392 +name: regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "regulation of prostaglandin anabolism" EXACT [] +synonym: "regulation of prostaglandin biosynthesis" EXACT [] +synonym: "regulation of prostaglandin formation" EXACT [] +synonym: "regulation of prostaglandin synthesis" EXACT [] +is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process +relationship: regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031393 +name: negative regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "down regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "down-regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "downregulation of prostaglandin biosynthetic process" EXACT [] +synonym: "inhibition of prostaglandin biosynthetic process" NARROW [] +synonym: "negative regulation of prostaglandin anabolism" EXACT [] +synonym: "negative regulation of prostaglandin biosynthesis" EXACT [] +synonym: "negative regulation of prostaglandin formation" EXACT [] +synonym: "negative regulation of prostaglandin synthesis" EXACT [] +is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process +is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process +relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031394 +name: positive regulation of prostaglandin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] +synonym: "activation of prostaglandin biosynthetic process" NARROW [] +synonym: "positive regulation of prostaglandin anabolism" EXACT [] +synonym: "positive regulation of prostaglandin biosynthesis" EXACT [] +synonym: "positive regulation of prostaglandin formation" EXACT [] +synonym: "positive regulation of prostaglandin synthesis" EXACT [] +synonym: "stimulation of prostaglandin biosynthetic process" NARROW [] +synonym: "up regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "up-regulation of prostaglandin biosynthetic process" EXACT [] +synonym: "upregulation of prostaglandin biosynthetic process" EXACT [] +is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process +is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process +relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process + +[Term] +id: GO:0031395 +name: bursicon neuropeptide hormone complex +namespace: cellular_component +def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0031396 +name: regulation of protein ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031397 +name: negative regulation of protein ubiquitination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] +synonym: "down regulation of protein ubiquitination" EXACT [] +synonym: "down-regulation of protein ubiquitination" EXACT [] +synonym: "downregulation of protein ubiquitination" EXACT [] +synonym: "inhibition of protein ubiquitination" NARROW [] +is_a: GO:0031396 ! regulation of protein ubiquitination +is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal +relationship: negatively_regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031398 +name: positive regulation of protein ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] +synonym: "activation of protein ubiquitination" NARROW [] +synonym: "stimulation of protein ubiquitination" NARROW [] +synonym: "up regulation of protein ubiquitination" EXACT [] +synonym: "up-regulation of protein ubiquitination" EXACT [] +synonym: "upregulation of protein ubiquitination" EXACT [] +is_a: GO:0031396 ! regulation of protein ubiquitination +is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal +relationship: positively_regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0031399 +name: regulation of protein modification process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +subset: goslim_yeast +is_a: GO:0032268 ! regulation of cellular protein metabolic process +relationship: regulates GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0031400 +name: negative regulation of protein modification process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +synonym: "down regulation of protein modification" EXACT [] +synonym: "down-regulation of protein modification" EXACT [] +synonym: "downregulation of protein modification" EXACT [] +synonym: "inhibition of protein modification" NARROW [] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0031401 +name: positive regulation of protein modification process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] +synonym: "activation of protein modification" NARROW [] +synonym: "stimulation of protein modification" NARROW [] +synonym: "up regulation of protein modification" EXACT [] +synonym: "up-regulation of protein modification" EXACT [] +synonym: "upregulation of protein modification" EXACT [] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0031402 +name: sodium ion binding +namespace: molecular_function +def: "Binding to a sodium ion (Na+)." [GOC:mah] +synonym: "Na+ ion binding" EXACT [] +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0031403 +name: lithium ion binding +namespace: molecular_function +def: "Binding to a lithium ion (Li+)." [GOC:mah] +synonym: "Li+ ion binding" EXACT [] +is_a: GO:0031420 ! alkali metal ion binding + +[Term] +id: GO:0031404 +name: chloride ion binding +namespace: molecular_function +def: "Binding to a chloride ion (Cl-)." [GOC:mah] +synonym: "chloride binding" EXACT [] +synonym: "Cl- ion binding" EXACT [] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0031405 +name: lipoic acid binding +namespace: molecular_function +def: "Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732] +is_a: GO:0005504 ! fatty acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0031406 +name: carboxylic acid binding +namespace: molecular_function +def: "Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] +subset: goslim_pir +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0031407 +name: oxylipin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] +synonym: "oxylipin metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0031408 +name: oxylipin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] +synonym: "oxylipin anabolism" EXACT [] +synonym: "oxylipin biosynthesis" EXACT [] +synonym: "oxylipin formation" EXACT [] +synonym: "oxylipin synthesis" EXACT [] +is_a: GO:0031407 ! oxylipin metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0031409 +name: pigment binding +namespace: molecular_function +def: "Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0031410 +name: cytoplasmic vesicle +namespace: cellular_component +alt_id: GO:0016023 +def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_generic +subset: goslim_mouse +subset: goslim_yeast +synonym: "cytoplasmic membrane bounded vesicle" RELATED [] +synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] +synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] +xref: NIF_Subcellular:sao180601769 +is_a: GO:0097708 ! intracellular vesicle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031411 +name: gas vesicle +namespace: cellular_component +def: "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations." [PMID:22147705, PMID:8177173] +comment: Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane. +synonym: "gas vacuole" RELATED [GOC:pr] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0031412 +name: gas vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah] +comment: Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane. +synonym: "gas vesicle biosynthesis" NARROW [GOC:mah] +synonym: "gas vesicle formation" NARROW [GOC:mah] +synonym: "gas vesicle organisation" EXACT [] +synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0031413 +name: regulation of buoyancy +namespace: biological_process +def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420] +synonym: "buoyancy regulation" EXACT [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0031414 +name: N-terminal protein acetyltransferase complex +namespace: cellular_component +def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] +synonym: "NAT complex" EXACT [] +is_a: GO:0031248 ! protein acetyltransferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031415 +name: NatA complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] +synonym: "N-terminal acetyltransferase A complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031416 +name: NatB complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] +synonym: "N-terminal acetyltransferase B complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031417 +name: NatC complex +namespace: cellular_component +def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] +synonym: "N-terminal acetyltransferase C complex" EXACT [] +is_a: GO:0031414 ! N-terminal protein acetyltransferase complex + +[Term] +id: GO:0031418 +name: L-ascorbic acid binding +namespace: molecular_function +def: "Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [GOC:mah] +synonym: "L-ascorbate binding" EXACT [] +synonym: "vitamin C binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0048029 ! monosaccharide binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0031419 +name: cobalamin binding +namespace: molecular_function +def: "Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] +synonym: "vitamin B12 binding" EXACT [] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0046906 ! tetrapyrrole binding + +[Term] +id: GO:0031420 +name: alkali metal ion binding +namespace: molecular_function +def: "Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0031421 +name: invertasome +namespace: cellular_component +def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0031422 +name: RecQ family helicase-topoisomerase III complex +namespace: cellular_component +def: "A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human." [GOC:bhm, GOC:krc, PMID:15889139] +synonym: "RecQ helicase-Topo III complex" EXACT [PMID:15889139] +synonym: "Sgs1-Top3 complex" NARROW [PMID:15889139] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0031423 +name: hexon binding +namespace: molecular_function +def: "Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031424 +name: keratinization +namespace: biological_process +def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0031425 +name: chloroplast RNA processing +namespace: biological_process +def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0031426 +name: polycistronic mRNA processing +namespace: biological_process +def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah] +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0031427 +name: response to methotrexate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:ef, GOC:mah, ISBN:0198506732] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0031428 +name: box C/D RNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya." [ISBN:0879695897, PMID:11842104, PMID:17284456] +synonym: "box C/D small nucleolar ribonucleoprotein complex" NARROW [GOC:cjm] +synonym: "box C/D snoRNP complex" NARROW [ISBN:0879695897] +synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456] +synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" NARROW [PMID:17284456] +synonym: "box C/D sRNP complex" NARROW [PMID:11842104] +is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex + +[Term] +id: GO:0031429 +name: box H/ACA snoRNP complex +namespace: cellular_component +def: "A box H/ACA RNP complex that is located in the nucleolus." [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365] +synonym: "box H/ACA small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm] +synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456] +is_a: GO:0072588 ! box H/ACA RNP complex +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0031430 +name: M band +namespace: cellular_component +def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] +synonym: "M disc" EXACT [] +synonym: "M line" NARROW [] +synonym: "mesophragma" EXACT [] +synonym: "midline" BROAD [] +xref: Wikipedia:Sarcomere#bands +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0031431 +name: Dbf4-dependent protein kinase complex +namespace: cellular_component +def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] +synonym: "Cdc7-Dbf4 complex" NARROW [] +synonym: "DDK" EXACT [] +synonym: "Hsk1-Dfp1 kinase complex" NARROW [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0031432 +name: titin binding +namespace: molecular_function +def: "Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031433 +name: telethonin binding +namespace: molecular_function +def: "Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0031434 +name: mitogen-activated protein kinase kinase binding +namespace: molecular_function +def: "Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase." [GOC:mah] +synonym: "MAPKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0031435 +name: mitogen-activated protein kinase kinase kinase binding +namespace: molecular_function +def: "Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase." [GOC:bf] +synonym: "MAPKKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0031436 +name: BRCA1-BARD1 complex +namespace: cellular_component +def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0031437 +name: regulation of mRNA cleavage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031438 +name: negative regulation of mRNA cleavage +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah] +synonym: "down regulation of mRNA cleavage" EXACT [] +synonym: "down-regulation of mRNA cleavage" EXACT [] +synonym: "downregulation of mRNA cleavage" EXACT [] +synonym: "inhibition of mRNA cleavage" NARROW [] +is_a: GO:0031437 ! regulation of mRNA cleavage +is_a: GO:1903312 ! negative regulation of mRNA metabolic process +relationship: negatively_regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031439 +name: positive regulation of mRNA cleavage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah] +synonym: "activation of mRNA cleavage" NARROW [] +synonym: "stimulation of mRNA cleavage" NARROW [] +synonym: "up regulation of mRNA cleavage" EXACT [] +synonym: "up-regulation of mRNA cleavage" EXACT [] +synonym: "upregulation of mRNA cleavage" EXACT [] +is_a: GO:0031437 ! regulation of mRNA cleavage +is_a: GO:1903313 ! positive regulation of mRNA metabolic process +relationship: positively_regulates GO:0006379 ! mRNA cleavage + +[Term] +id: GO:0031440 +name: regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] +is_a: GO:0050684 ! regulation of mRNA processing +relationship: regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031441 +name: negative regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] +synonym: "down regulation of mRNA 3'-end processing" EXACT [] +synonym: "down-regulation of mRNA 3'-end processing" EXACT [] +synonym: "downregulation of mRNA 3'-end processing" EXACT [] +synonym: "inhibition of mRNA 3'-end processing" NARROW [] +is_a: GO:0031440 ! regulation of mRNA 3'-end processing +is_a: GO:0050686 ! negative regulation of mRNA processing +relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031442 +name: positive regulation of mRNA 3'-end processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] +synonym: "activation of mRNA 3'-end processing" NARROW [] +synonym: "stimulation of mRNA 3'-end processing" NARROW [] +synonym: "up regulation of mRNA 3'-end processing" EXACT [] +synonym: "up-regulation of mRNA 3'-end processing" EXACT [] +synonym: "upregulation of mRNA 3'-end processing" EXACT [] +is_a: GO:0031440 ! regulation of mRNA 3'-end processing +is_a: GO:0050685 ! positive regulation of mRNA processing +relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0031443 +name: fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle] +synonym: "fast-twitch skeletal fiber contraction" EXACT [] +synonym: "fast-twitch skeletal fibre contraction" EXACT [] +synonym: "fast-twitch skeletal muscle fibre contraction" EXACT [] +synonym: "fast-twitch skeletal myofiber contraction" EXACT [] +synonym: "fast-twitch skeletal myofibre contraction" EXACT [] +is_a: GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0031444 +name: slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle] +synonym: "slow-twitch skeletal muscle fibre contraction" EXACT [] +is_a: GO:0014721 ! twitch skeletal muscle contraction + +[Term] +id: GO:0031445 +name: regulation of heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] +synonym: "regulation of heterochromatin formation" EXACT [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0010847 ! regulation of chromatin assembly +is_a: GO:0120261 ! regulation of heterochromatin organization +relationship: regulates GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0031446 +name: regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction +relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031447 +name: negative regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031448 +name: positive regulation of fast-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "activation of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW [] +synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT [] +synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT [] +is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031449 +name: regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction +relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031450 +name: negative regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031451 +name: positive regulation of slow-twitch skeletal muscle fiber contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] +synonym: "activation of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW [] +synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT [] +synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT [] +is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction + +[Term] +id: GO:0031452 +name: negative regulation of heterochromatin assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] +synonym: "down regulation of heterochromatin formation" EXACT [] +synonym: "down-regulation of heterochromatin formation" EXACT [] +synonym: "downregulation of heterochromatin formation" EXACT [] +synonym: "inhibition of heterochromatin formation" NARROW [] +synonym: "negative regulation of heterochromatin formation" EXACT [] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0031445 ! regulation of heterochromatin assembly +is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly +is_a: GO:0120262 ! negative regulation of heterochromatin organization +relationship: negatively_regulates GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0031453 +name: positive regulation of heterochromatin assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] +synonym: "activation of heterochromatin formation" NARROW [] +synonym: "positive regulation of heterochromatin formation" EXACT [] +synonym: "stimulation of heterochromatin formation" NARROW [] +synonym: "up regulation of heterochromatin formation" EXACT [] +synonym: "up-regulation of heterochromatin formation" EXACT [] +synonym: "upregulation of heterochromatin formation" EXACT [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly +is_a: GO:0120263 ! positive regulation of heterochromatin organization +relationship: positively_regulates GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0031455 +name: glycine betaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah] +synonym: "glycine betaine metabolism" EXACT [] +synonym: "N-trimethylglycine metabolic process" EXACT [] +synonym: "N-trimethylglycine metabolism" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process + +[Term] +id: GO:0031456 +name: glycine betaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah] +synonym: "glycine betaine anabolism" EXACT [] +synonym: "glycine betaine biosynthesis" EXACT [] +synonym: "glycine betaine formation" EXACT [] +synonym: "glycine betaine synthesis" EXACT [] +synonym: "N-trimethylglycine biosynthesis" EXACT [] +synonym: "N-trimethylglycine biosynthetic process" EXACT [] +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0031455 ! glycine betaine metabolic process + +[Term] +id: GO:0031457 +name: glycine betaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah] +synonym: "glycine betaine breakdown" EXACT [] +synonym: "glycine betaine catabolism" EXACT [] +synonym: "glycine betaine degradation" EXACT [] +synonym: "N-trimethylglycine catabolic process" EXACT [] +synonym: "N-trimethylglycine catabolism" EXACT [] +is_a: GO:0006579 ! amino-acid betaine catabolic process +is_a: GO:0031455 ! glycine betaine metabolic process + +[Term] +id: GO:0031458 +name: ABC-type betaine transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] +synonym: "ABC-type betaine transmembrane transporter activity" EXACT [] +synonym: "ATP-dependent betaine transporter activity" EXACT [] +synonym: "ATPase-coupled betaine transporter activity" RELATED [] +synonym: "betaine ABC transporter" NARROW [] +synonym: "betaine-transporting ATPase activity" EXACT [] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0031459 +name: ABC-type glycine betaine transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg, RHEA:32783] +synonym: "ATP-dependent glycine betaine transporter activity" EXACT [] +synonym: "ATPase-coupled glycine betaine transporter activity" RELATED [] +synonym: "glycine betaine ABC transporter" NARROW [] +synonym: "glycine betaine-transporting ATPase activity" RELATED [] +synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] +xref: RHEA:32783 +is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity +is_a: GO:0015418 ! ABC-type quaternary ammonium compound transporting activity + +[Term] +id: GO:0031460 +name: glycine betaine transport +namespace: biological_process +def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "N-trimethylglycine transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015838 ! amino-acid betaine transport + +[Term] +id: GO:0031461 +name: cullin-RING ubiquitin ligase complex +namespace: cellular_component +def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] +synonym: "CRL complex" EXACT [] +synonym: "cullin complex" EXACT [] +synonym: "cullin-RING ligase" RELATED [] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:0031462 +name: Cul2-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] +synonym: "CBC complex" BROAD [] +synonym: "CDL2 complex" EXACT [] +synonym: "CRL2 complex" EXACT [] +synonym: "cullin-RING ligase 2" EXACT [] +synonym: "EC2S complex" BROAD [] +synonym: "ECS complex" BROAD [] +synonym: "SCF2 complex" RELATED [] +synonym: "VBC complex" NARROW [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031463 +name: Cul3-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] +synonym: "BC3B complex" EXACT [] +synonym: "BCR3 complex" EXACT [] +synonym: "CDL3 complex" EXACT [] +synonym: "CRL3 complex" EXACT [] +synonym: "cullin-RING ligase 3" EXACT [] +synonym: "SCF3 complex" RELATED [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031464 +name: Cul4A-RING E3 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] +synonym: "CDL4 complex" EXACT [] +synonym: "CRL4 complex" EXACT [] +synonym: "cullin-RING ligase 4A" EXACT [] +synonym: "DCX complex" EXACT [] +synonym: "SCF4 complex" RELATED [] +synonym: "VDC complex" NARROW [] +is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex + +[Term] +id: GO:0031465 +name: Cul4B-RING E3 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] +synonym: "cullin-RING ligase 4B" EXACT [] +is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex + +[Term] +id: GO:0031466 +name: Cul5-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] +synonym: "CDL5 complex" EXACT [] +synonym: "CRL5 complex" EXACT [] +synonym: "cullin-RING ligase 5" EXACT [] +synonym: "EC2S complex" BROAD [] +synonym: "SCF5 complex" RELATED [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031467 +name: Cul7-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] +synonym: "CDL7 complex" EXACT [] +synonym: "CRL7 complex" EXACT [] +synonym: "cullin-RING ligase 7" EXACT [] +synonym: "SCF7 complex" EXACT [] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0031468 +name: nuclear membrane reassembly +namespace: biological_process +def: "The reformation of the nuclear membranes following their breakdown in the context of a normal process." [GOC:mah] +synonym: "nuclear envelope reassembly" RELATED [] +is_a: GO:0071709 ! membrane assembly +is_a: GO:0071763 ! nuclear membrane organization + +[Term] +id: GO:0031469 +name: bacterial microcompartment +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081, PMID:34058518, PMID:34340100] +subset: goslim_pir +synonym: "BAC" BROAD [] +synonym: "BMC" BROAD [] +synonym: "MCP" BROAD [] +synonym: "polyhedral organelle" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0031470 +name: carboxysome +namespace: cellular_component +def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions." [GOC:js, PMID:28934381, PMID:8157606, PMID:8491708] +xref: Wikipedia:Carboxysome +is_a: GO:0031469 ! bacterial microcompartment + +[Term] +id: GO:0031471 +name: ethanolamine degradation polyhedral organelle +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] +synonym: "ethanolamine metabolosome" RELATED [] +is_a: GO:0031469 ! bacterial microcompartment + +[Term] +id: GO:0031472 +name: propanediol degradation polyhedral organelle +namespace: cellular_component +def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] +is_a: GO:0031469 ! bacterial microcompartment + +[Term] +id: GO:0031473 +name: myosin III binding +namespace: molecular_function +def: "Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0031474 +name: myosin IV complex +namespace: cellular_component +def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [Wikipedia:Myosin] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031475 +name: myosin V complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [Wikipedia:Myosin] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031476 +name: myosin VI complex +namespace: cellular_component +def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031477 +name: myosin VII complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031478 +name: myosin VIII complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031479 +name: myosin IX complex +namespace: cellular_component +def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031480 +name: myosin X complex +namespace: cellular_component +def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031481 +name: myosin XI complex +namespace: cellular_component +def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031482 +name: myosin XII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031483 +name: myosin XIII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031484 +name: myosin XIV complex +namespace: cellular_component +def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031485 +name: myosin XV complex +namespace: cellular_component +def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031486 +name: myosin XVI complex +namespace: cellular_component +def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031487 +name: myosin XVII complex +namespace: cellular_component +def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031488 +name: myosin XVIII complex +namespace: cellular_component +def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0031489 +name: myosin V binding +namespace: molecular_function +def: "Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0031490 +name: chromatin DNA binding +namespace: molecular_function +def: "Binding to DNA that is assembled into chromatin." [GOC:mah] +is_a: GO:0003677 ! DNA binding +is_a: GO:0003682 ! chromatin binding + +[Term] +id: GO:0031491 +name: nucleosome binding +namespace: molecular_function +def: "Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] +is_a: GO:0003682 ! chromatin binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0031492 +name: nucleosomal DNA binding +namespace: molecular_function +def: "Binding to the DNA portion of a nucleosome." [GOC:mah] +is_a: GO:0031490 ! chromatin DNA binding +is_a: GO:0031491 ! nucleosome binding + +[Term] +id: GO:0031493 +name: obsolete nucleosomal histone binding +namespace: molecular_function +def: "OBSOLETE. Binding to a histone that is assembled into a nucleosome." [GOC:mah] +comment: This term was obsoleted because it represents both an activity and a cellular component. +is_obsolete: true +consider: GO:0000786 +consider: GO:0042393 + +[Term] +id: GO:0031494 +name: regulation of mating type switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031495 +name: negative regulation of mating type switching +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah] +synonym: "down regulation of mating type switching" EXACT [] +synonym: "down-regulation of mating type switching" EXACT [] +synonym: "downregulation of mating type switching" EXACT [] +synonym: "inhibition of mating type switching" NARROW [] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0031494 ! regulation of mating type switching +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031496 +name: positive regulation of mating type switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah] +synonym: "activation of mating type switching" NARROW [] +synonym: "stimulation of mating type switching" NARROW [] +synonym: "up regulation of mating type switching" EXACT [] +synonym: "up-regulation of mating type switching" EXACT [] +synonym: "upregulation of mating type switching" EXACT [] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0031494 ! regulation of mating type switching +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0007533 ! mating type switching + +[Term] +id: GO:0031497 +name: chromatin assembly +namespace: biological_process +def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] +synonym: "chromatin maintenance" BROAD [] +synonym: "establishment of chromatin architecture" EXACT [GOC:mah] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0006323 ! DNA packaging + +[Term] +id: GO:0031498 +name: chromatin disassembly +namespace: biological_process +def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] +synonym: "chromatin maintenance" BROAD [] +is_a: GO:0006333 ! chromatin assembly or disassembly +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:0031499 +name: TRAMP complex +namespace: cellular_component +def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137] +synonym: "TRAMP4 complex" NARROW [] +synonym: "TRAMP5 complex" NARROW [] +synonym: "Trf4 complex" NARROW [] +synonym: "Trf4 poly(A) polymerase complex" NARROW [] +synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW [] +xref: Wikipedia:TRAMP_complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0031500 +name: Tea1 cell-end complex +namespace: cellular_component +def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] +is_a: GO:0005875 ! microtubule associated complex +relationship: part_of GO:0000133 ! polarisome + +[Term] +id: GO:0031501 +name: mannosyltransferase complex +namespace: cellular_component +def: "A complex that posseses mannosyltransferase activity." [GOC:mah] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0031502 +name: dolichyl-phosphate-mannose-protein mannosyltransferase complex +namespace: cellular_component +def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, GOC:pr, PMID:15948957] +comment: Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. +synonym: "PMT family mannosyltransferase complex" RELATED [] +synonym: "protein O-mannosyltransferase complex" EXACT [] +is_a: GO:0031501 ! mannosyltransferase complex +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0031503 +name: protein-containing complex localization +namespace: biological_process +alt_id: GO:0034629 +def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "cellular protein complex localisation" RELATED [GOC:mah] +synonym: "cellular protein complex localization" RELATED [] +synonym: "cellular protein-containing complex localization" RELATED [] +synonym: "establishment and maintenance of cellular protein complex localization" RELATED [] +synonym: "establishment and maintenance of protein complex localization" EXACT [] +synonym: "protein complex localisation" EXACT [GOC:mah] +synonym: "protein complex localization" RELATED [] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0031504 +name: peptidoglycan-based cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] +synonym: "peptidoglycan-based cell wall organisation" EXACT [GOC:mah] +synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071555 ! cell wall organization + +[Term] +id: GO:0031505 +name: fungal-type cell wall organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] +synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] +synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW [] +synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] +synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] +synonym: "fungal-type cell wall organization and biogenesis" RELATED [] +is_a: GO:0071555 ! cell wall organization +is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis + +[Term] +id: GO:0031506 +name: cell wall glycoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah] +synonym: "cell wall glycoprotein anabolism" EXACT [] +synonym: "cell wall glycoprotein biosynthesis" EXACT [] +synonym: "cell wall glycoprotein formation" EXACT [] +synonym: "cell wall glycoprotein synthesis" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process + +[Term] +id: GO:0031507 +name: heterochromatin assembly +namespace: biological_process +alt_id: GO:0006342 +alt_id: GO:0006343 +alt_id: GO:0016440 +alt_id: GO:0070869 +alt_id: GO:1904497 +def: "An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation." [GOC:mah, PMID:25192661, PMID:33827924] +synonym: "chromatin silencing" EXACT [] +synonym: "chromatin-mediated silencing" EXACT [] +synonym: "establishment of chromatin silencing" RELATED [] +synonym: "establishment of heterochromatic silencing" RELATED [] +synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] +synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] +synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] +synonym: "heterochromatic silencing" RELATED [] +synonym: "heterochromatin assembly involved in chromatin silencing" RELATED [] +synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" NARROW [] +synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] +synonym: "heterochromatin formation" EXACT [] +synonym: "heterochromatin formation involved in chromatin silencing" RELATED [] +synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" NARROW [GOC:TermGenie] +synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" NARROW [GOC:TermGenie] +synonym: "heterochromatin maintenance" BROAD [] +synonym: "TGS" BROAD [] +synonym: "transcriptional gene silencing" EXACT [] +is_a: GO:0031497 ! chromatin assembly +is_a: GO:0045814 ! negative regulation of gene expression, epigenetic +is_a: GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0031508 +name: pericentric heterochromatin assembly +namespace: biological_process +alt_id: GO:0030702 +alt_id: GO:1990141 +def: "The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA." [GOC:mah, PMID:20206496, PMID:22729156] +synonym: "centric heterochromatin formation" RELATED [] +synonym: "centromere chromatin silencing" EXACT [GOC:mah] +synonym: "centromeric heterochromatin biosynthesis" EXACT [] +synonym: "centromeric heterochromatin formation" EXACT [] +synonym: "centromeric silencing" EXACT [GOC:vw] +synonym: "chromatin silencing at centromere" EXACT [] +synonym: "chromatin silencing at centromere outer repeat region" NARROW [] +synonym: "chromatin silencing at pericentric region" RELATED [GOC:mah] +synonym: "heterochromatic silencing at centromere" EXACT [] +is_a: GO:0031055 ! chromatin remodeling at centromere +is_a: GO:0140462 ! pericentric heterochromatin organization +is_a: GO:0140719 ! constitutive heterochromatin assembly +relationship: part_of GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0031509 +name: subtelomeric heterochromatin assembly +namespace: biological_process +alt_id: GO:0006348 +alt_id: GO:0035390 +alt_id: GO:0099114 +def: "The assembly of chromatin into heterochromatin at the subtelomeric region, resulting in a chromatin conformation refractory to transcription." [GOC:mah, PMID:10219245, PMID:26205977] +synonym: "chromatin silencing at subtelomere" RELATED [] +synonym: "chromatin silencing at telomere" EXACT [] +synonym: "establishment of chromatin silencing at telomere" RELATED [] +synonym: "heterochromatic silencing at subtelomere" RELATED [] +synonym: "heterochromatic silencing at telomere" EXACT [] +synonym: "regulation of chromatin silencing at telomere" RELATED [] +synonym: "regulation of subtelomeric heterochromatin assembly" RELATED [] +synonym: "subtelomere chromatin silencing" RELATED [GOC:mah] +synonym: "subtelomeric silencing" EXACT [GOC:mah] +synonym: "telomere chromatin silencing" EXACT [GOC:mah] +synonym: "Telomere Position Effect" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:21847107] +synonym: "telomeric heterochromatin assembly" RELATED [] +synonym: "telomeric heterochromatin formation" RELATED [] +synonym: "telomeric silencing" EXACT [GOC:bf] +is_a: GO:0140719 ! constitutive heterochromatin assembly +relationship: part_of GO:0032200 ! telomere organization + +[Term] +id: GO:0031510 +name: SUMO activating enzyme complex +namespace: cellular_component +def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] +synonym: "SAE" EXACT [] +synonym: "SUMO E1 activator enzyme complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0031511 +name: Mis6-Sim4 complex +namespace: cellular_component +def: "A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] +synonym: "Mis6 centromere subcomplex" NARROW [] +synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296] +synonym: "Sim4 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000939 ! inner kinetochore + +[Term] +id: GO:0031514 +name: motile cilium +namespace: cellular_component +alt_id: GO:0009434 +alt_id: GO:0031512 +def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] +synonym: "microtubule-based flagellum" RELATED [] +synonym: "motile cilia" EXACT [] +synonym: "motile primary cilia" RELATED [] +synonym: "motile primary cilium" RELATED [] +synonym: "motile secondary cilium" RELATED [] +synonym: "nodal cilium" RELATED [] +is_a: GO:0005929 ! cilium + +[Term] +id: GO:0031515 +name: tRNA (m1A) methyltransferase complex +namespace: cellular_component +def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] +is_a: GO:0043527 ! tRNA methyltransferase complex + +[Term] +id: GO:0031516 +name: far-red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] +is_a: GO:0009883 ! red or far-red light photoreceptor activity + +[Term] +id: GO:0031517 +name: red light photoreceptor activity +namespace: molecular_function +def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] +is_a: GO:0009883 ! red or far-red light photoreceptor activity + +[Term] +id: GO:0031518 +name: CBF3 complex +namespace: cellular_component +def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0031519 +name: PcG protein complex +namespace: cellular_component +def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] +subset: goslim_pir +synonym: "Polycomb Group protein complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0031520 +name: plasma membrane of cell tip +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] +synonym: "'plasma membrane, cell tip'" EXACT [] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0051286 ! cell tip + +[Term] +id: GO:0031521 +name: spitzenkorper +namespace: cellular_component +def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0001411 ! hyphal tip +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0031522 +name: cell envelope Sec protein transport complex +namespace: cellular_component +def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] +comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. +synonym: "plasma membrane Sec complex" RELATED [] +synonym: "Sec complex" BROAD [] +synonym: "Sec secretion complex" NARROW [] +synonym: "Sec translocation complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0031523 +name: Myb complex +namespace: cellular_component +def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] +synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0031524 +name: menthol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] +synonym: "menthol metabolism" EXACT [] +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0031525 +name: menthol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] +synonym: "menthol anabolism" EXACT [] +synonym: "menthol biosynthesis" EXACT [] +synonym: "menthol formation" EXACT [] +synonym: "menthol synthesis" EXACT [] +is_a: GO:0016099 ! monoterpenoid biosynthetic process +is_a: GO:0031524 ! menthol metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0031526 +name: brush border membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0005903 ! brush border + +[Term] +id: GO:0031527 +name: filopodium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0030175 ! filopodium + +[Term] +id: GO:0031528 +name: microvillus membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0005902 ! microvillus + +[Term] +id: GO:0031529 +name: ruffle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] +synonym: "ruffle organisation" EXACT [GOC:mah] +synonym: "ruffle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0031530 +name: gonadotropin-releasing hormone receptor binding +namespace: molecular_function +def: "Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [GOC:pr, PMID:15196882] +synonym: "GnRH receptor binding" EXACT [] +synonym: "gonadotrophin-releasing hormone receptor binding" EXACT [GOC:dph] +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0031531 +name: thyrotropin-releasing hormone receptor binding +namespace: molecular_function +alt_id: GO:0031888 +def: "Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] +synonym: "thyrotropin releasing hormone receptor binding" EXACT [] +synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0031532 +name: actin cytoskeleton reorganization +namespace: biological_process +alt_id: GO:0007012 +def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] +synonym: "actin cytoskeleton remodeling" EXACT [] +synonym: "actin cytoskeleton reorganisation" EXACT [] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0031533 +name: mRNA cap methyltransferase complex +namespace: cellular_component +def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] +synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] +synonym: "mRNA capping enzyme complex" EXACT [GOC:vw] +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0031534 +name: minus-end directed microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] +is_a: GO:0051012 ! microtubule sliding + +[Term] +id: GO:0031535 +name: plus-end directed microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw] +is_a: GO:0051012 ! microtubule sliding + +[Term] +id: GO:0031536 +name: positive regulation of exit from mitosis +namespace: biological_process +def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] +synonym: "activation of exit from mitosis" NARROW [] +synonym: "stimulation of exit from mitosis" NARROW [] +synonym: "up regulation of exit from mitosis" EXACT [] +synonym: "up-regulation of exit from mitosis" EXACT [] +synonym: "upregulation of exit from mitosis" EXACT [] +is_a: GO:0007096 ! regulation of exit from mitosis +is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition +relationship: positively_regulates GO:0010458 ! exit from mitosis + +[Term] +id: GO:0031537 +name: regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "regulation of anthocyanin metabolism" EXACT [] +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0046283 ! anthocyanin-containing compound metabolic process + +[Term] +id: GO:0031538 +name: negative regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "down regulation of anthocyanin metabolic process" EXACT [] +synonym: "down-regulation of anthocyanin metabolic process" EXACT [] +synonym: "downregulation of anthocyanin metabolic process" EXACT [] +synonym: "inhibition of anthocyanin metabolic process" NARROW [] +synonym: "negative regulation of anthocyanin metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process + +[Term] +id: GO:0031539 +name: positive regulation of anthocyanin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] +synonym: "activation of anthocyanin metabolic process" NARROW [] +synonym: "positive regulation of anthocyanin metabolism" EXACT [] +synonym: "stimulation of anthocyanin metabolic process" NARROW [] +synonym: "up regulation of anthocyanin metabolic process" EXACT [] +synonym: "up-regulation of anthocyanin metabolic process" EXACT [] +synonym: "upregulation of anthocyanin metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process + +[Term] +id: GO:0031540 +name: regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "regulation of anthocyanin anabolism" EXACT [] +synonym: "regulation of anthocyanin biosynthesis" EXACT [] +synonym: "regulation of anthocyanin formation" EXACT [] +synonym: "regulation of anthocyanin synthesis" EXACT [] +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process + +[Term] +id: GO:0031541 +name: negative regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "down regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "down-regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "downregulation of anthocyanin biosynthetic process" EXACT [] +synonym: "inhibition of anthocyanin biosynthetic process" NARROW [] +synonym: "negative regulation of anthocyanin anabolism" EXACT [] +synonym: "negative regulation of anthocyanin biosynthesis" EXACT [] +synonym: "negative regulation of anthocyanin formation" EXACT [] +synonym: "negative regulation of anthocyanin synthesis" EXACT [] +is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process +is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process +is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process +relationship: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process + +[Term] +id: GO:0031542 +name: positive regulation of anthocyanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] +synonym: "activation of anthocyanin biosynthetic process" NARROW [] +synonym: "positive regulation of anthocyanin anabolism" EXACT [] +synonym: "positive regulation of anthocyanin biosynthesis" EXACT [] +synonym: "positive regulation of anthocyanin formation" EXACT [] +synonym: "positive regulation of anthocyanin synthesis" EXACT [] +synonym: "stimulation of anthocyanin biosynthetic process" NARROW [] +synonym: "up regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "up-regulation of anthocyanin biosynthetic process" EXACT [] +synonym: "upregulation of anthocyanin biosynthetic process" EXACT [] +is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process +is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process +is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process +relationship: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process + +[Term] +id: GO:0031543 +name: peptidyl-proline dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462] +synonym: "proline hydroxylase activity" BROAD [GOC:krc, GOC:pr] +synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [GOC:krc, GOC:pr] +synonym: "prolyl 4-hydroxylase activity" BROAD [GOC:krc, GOC:pr] +synonym: "prolyl hydroxylase activity" BROAD [GOC:krc, GOC:pr] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0031544 +name: peptidyl-proline 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0031545 +name: peptidyl-proline 4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] +synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] +synonym: "prolyl 4-hydroxylase" BROAD [] +xref: Reactome:R-HSA-1234165 "Nuclear PHD1,3 hydroxylates proline residues on HIF3A" +xref: Reactome:R-HSA-1234166 "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)" +xref: Reactome:R-HSA-1234173 "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A" +xref: Reactome:R-HSA-1234177 "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A" +xref: Reactome:R-HSA-1234179 "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)" +xref: Reactome:R-HSA-1234181 "Nuclear PHD1,3 hydroxylates proline residues on HIF1A" +is_a: GO:0031543 ! peptidyl-proline dioxygenase activity + +[Term] +id: GO:0031546 +name: brain-derived neurotrophic factor receptor binding +namespace: molecular_function +def: "Binding to a brain-derived neurotrophic factor receptor." [GOC:mah] +synonym: "BDNF receptor binding" EXACT [] +synonym: "brain-derived neurotrophic factor ligand" NARROW [] +is_a: GO:0005165 ! neurotrophin receptor binding + +[Term] +id: GO:0031547 +name: brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "BDNF receptor signaling pathway" EXACT [] +synonym: "BDNF signalling pathway" EXACT [] +synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0031548 +name: regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031549 +name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "negative regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway +relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031550 +name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] +synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of BDNF receptor signaling pathway" EXACT [] +synonym: "positive regulation of BDNF receptor signalling pathway" EXACT [] +synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] +synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] +synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway +relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway + +[Term] +id: GO:0031551 +name: regulation of brain-derived neurotrophic factor-activated receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] +synonym: "regulation of BDNF receptor activity" EXACT [] +synonym: "regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity + +[Term] +id: GO:0031552 +name: negative regulation of brain-derived neurotrophic factor-activated receptor activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] +synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "negative regulation of BDNF receptor activity" EXACT [] +synonym: "negative regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway +is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity +is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0031553 +name: positive regulation of brain-derived neurotrophic factor-activated receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] +synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "positive regulation of BDNF receptor activity" EXACT [] +synonym: "positive regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW [] +synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] +synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT [] +is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway +is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity +is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0031554 +name: regulation of DNA-templated transcription, termination +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH] +synonym: "regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] +synonym: "regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] +synonym: "transcription antiterminator activity" RELATED [] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +is_a: GO:2001141 ! regulation of RNA biosynthetic process +relationship: regulates GO:0006353 ! DNA-templated transcription, termination + +[Term] +id: GO:0031555 +name: transcriptional attenuation +namespace: biological_process +def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682] +xref: Wikipedia:Attenuator_(genetics) +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination + +[Term] +id: GO:0031556 +name: transcriptional attenuation by ribosome +namespace: biological_process +def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682] +synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031555 ! transcriptional attenuation + +[Term] +id: GO:0031557 +name: obsolete induction of programmed cell death in response to chemical stimulus +namespace: biological_process +def: "OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] +comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0012501 programmed cell death. +synonym: "induction of programmed cell death in response to chemical stimulus" EXACT [] +synonym: "induction of programmed cell death in response to chemical substance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031558 +name: obsolete induction of apoptosis in response to chemical stimulus +namespace: biological_process +def: "OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] +comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0006915 apoptotic process. +synonym: "induction of apoptosis in response to chemical stimulus" EXACT [] +synonym: "induction of apoptosis in response to chemical substance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031559 +name: oxidosqualene cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct] +comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. +synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah] +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0031560 +name: cellular bud neck polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0031561 +name: cellular bud tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0005934 ! cellular bud tip + +[Term] +id: GO:0031562 +name: hyphal tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0001411 ! hyphal tip + +[Term] +id: GO:0031563 +name: mating projection tip polarisome +namespace: cellular_component +def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] +is_a: GO:0000133 ! polarisome +relationship: part_of GO:0043332 ! mating projection tip + +[Term] +id: GO:0031564 +name: transcription antitermination +namespace: biological_process +def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s)." [ISBN:0198577788, PMID:12456320] +synonym: "transcriptional readthrough" EXACT [] +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination + +[Term] +id: GO:0031565 +name: obsolete cytokinesis checkpoint +namespace: biological_process +alt_id: GO:0000135 +def: "OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition." [GOC:mtg_cell_cycle] +comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. +synonym: "contractile ring checkpoint" EXACT [] +synonym: "septin checkpoint" EXACT [] +is_obsolete: true +consider: GO:0044878 +consider: GO:0044879 + +[Term] +id: GO:0031566 +name: actomyosin contractile ring maintenance +namespace: biological_process +def: "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] +synonym: "contractile ring maintenance involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0036212 ! contractile ring maintenance +is_a: GO:0044837 ! actomyosin contractile ring organization + +[Term] +id: GO:0031567 +name: mitotic cell size control checkpoint signaling +namespace: biological_process +alt_id: GO:0072471 +def: "A signal transduction process that contributes to a cell size control checkpoint during mitosis." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle cell size control checkpoint" RELATED [GOC:mah] +synonym: "mitotic cell size control checkpoint" RELATED [] +synonym: "signal transduction involved in cell size control checkpoint" RELATED [] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition + +[Term] +id: GO:0031568 +name: mitotic G1 cell size control checkpoint signaling +namespace: biological_process +alt_id: GO:0072450 +def: "A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle] +synonym: "G1 cell size control checkpoint" RELATED [] +synonym: "G1 cell size control checkpoint signalling" RELATED [] +synonym: "mitotic cell cycle G1/S transition size control checkpoint" EXACT [] +synonym: "mitotic G1 cell size control checkpoint" EXACT [] +synonym: "signal transduction involved in G1 cell size control checkpoint" RELATED [] +synonym: "signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [] +is_a: GO:0031567 ! mitotic cell size control checkpoint signaling +is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle + +[Term] +id: GO:0031569 +name: mitotic G2 cell size control checkpoint signaling +namespace: biological_process +alt_id: GO:0072453 +def: "A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis." [GOC:mtg_cell_cycle] +synonym: "G2 cell size control checkpoint" EXACT [] +synonym: "G2/M transition size control checkpoint" EXACT [] +synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] +synonym: "mitotic G2 cell size control checkpoint" RELATED [] +synonym: "signal transduction involved in G2 cell size control checkpoint" RELATED [] +synonym: "signal transduction involved in G2/M transition size control checkpoint" RELATED [] +synonym: "signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah] +is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle +is_a: GO:0031567 ! mitotic cell size control checkpoint signaling + +[Term] +id: GO:0031570 +name: DNA integrity checkpoint signaling +namespace: biological_process +alt_id: GO:0072401 +def: "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] +synonym: "DNA integrity checkpoint" EXACT [] +synonym: "signal transduction involved in DNA integrity checkpoint" EXACT [] +is_a: GO:0000075 ! cell cycle checkpoint signaling + +[Term] +id: GO:0031571 +name: mitotic G1 DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:0044783 +alt_id: GO:0072431 +alt_id: GO:1902400 +def: "A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] +synonym: "G1 DNA damage checkpoint" RELATED [] +synonym: "G1/S DNA damage checkpoint" RELATED [] +synonym: "intracellular signal transduction involved in G1 DNA damage checkpoint" EXACT [] +synonym: "intracellular signal transduction involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] +synonym: "mitotic G1 DNA damage checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [] +synonym: "signal transduction involved in mitotic G1 DNA damage checkpoint" RELATED [] +synonym: "signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling +is_a: GO:0044819 ! mitotic G1/S transition checkpoint signaling + +[Term] +id: GO:0031573 +name: mitotic intra-S DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:0072428 +def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw] +synonym: "intra-S DNA damage checkpoint" EXACT [] +synonym: "mitotic intra-S DNA damage checkpoint" EXACT [] +synonym: "S-phase checkpoint" BROAD [] +synonym: "signal transduction involved in intra-S DNA damage checkpoint" EXACT [] +is_a: GO:0044773 ! mitotic DNA damage checkpoint signaling + +[Term] +id: GO:0031577 +name: spindle checkpoint signaling +namespace: biological_process +alt_id: GO:0072416 +def: "A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term. +subset: gocheck_do_not_manually_annotate +synonym: "signal transduction involved in spindle checkpoint" EXACT [] +synonym: "spindle checkpoint" EXACT [] +xref: Wikipedia:Spindle_checkpoint +is_a: GO:0000075 ! cell cycle checkpoint signaling + +[Term] +id: GO:0031578 +name: mitotic spindle orientation checkpoint signaling +namespace: biological_process +alt_id: GO:0072483 +def: "A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected." [GOC:mtg_cell_cycle, PMID:14616062] +synonym: "mitotic cell cycle spindle orientation checkpoint" EXACT [] +synonym: "mitotic spindle orientation checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic cell cycle spindle orientation checkpoint" EXACT [] +synonym: "SOC" EXACT [] +synonym: "spindle position checkpoint" EXACT [] +synonym: "SPOC" EXACT [] +is_a: GO:0001100 ! negative regulation of exit from mitosis +is_a: GO:0071174 ! mitotic spindle checkpoint signaling + +[Term] +id: GO:0031579 +name: membrane raft organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah] +synonym: "lipid raft organization" EXACT [GOC:mah] +synonym: "membrane raft organisation" EXACT [GOC:mah] +synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0031580 +name: membrane raft distribution +namespace: biological_process +def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah] +synonym: "lipid raft distribution" EXACT [] +is_a: GO:0031579 ! membrane raft organization +is_a: GO:0051665 ! membrane raft localization + +[Term] +id: GO:0031581 +name: hemidesmosome assembly +namespace: biological_process +def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403] +is_a: GO:0007044 ! cell-substrate junction assembly + +[Term] +id: GO:0031582 +name: replication fork arrest at rDNA repeats +namespace: biological_process +def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] +synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] +synonym: "replication fork blocking at rDNA repeats" EXACT [] +is_a: GO:0043007 ! maintenance of rDNA +is_a: GO:0043111 ! replication fork arrest + +[Term] +id: GO:0031583 +name: phospholipase D-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA)." [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269] +comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation. +synonym: "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] +synonym: "G-protein signalling, phospholipase D activating pathway" EXACT [] +synonym: "phospholipase D-activating G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0031584 +name: activation of phospholipase D activity +namespace: biological_process +def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0010518 ! positive regulation of phospholipase activity + +[Term] +id: GO:0031585 +name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] +synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling] +synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:0031586 +name: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] +synonym: "down regulation of IP3 receptor activity" EXACT [] +synonym: "down-regulation of IP3 receptor activity" EXACT [] +synonym: "downregulation of IP3 receptor activity" EXACT [] +synonym: "inhibition of IP3 receptor activity" NARROW [] +synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling] +synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph] +is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +is_a: GO:0050849 ! negative regulation of calcium-mediated signaling +is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:0031587 +name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] +synonym: "activation of IP3 receptor activity" NARROW [] +synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf] +synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph] +synonym: "stimulation of IP3 receptor activity" NARROW [] +synonym: "up regulation of IP3 receptor activity" EXACT [] +synonym: "up-regulation of IP3 receptor activity" EXACT [] +synonym: "upregulation of IP3 receptor activity" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity +is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:0031588 +name: nucleotide-activated protein kinase complex +namespace: cellular_component +def: "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw] +synonym: "5'-AMP-activated protein kinase complex" NARROW [] +synonym: "ADP-activated protein kinase complex" NARROW [] +synonym: "AMP-activated protein kinase complex" NARROW [] +synonym: "AMPK complex" RELATED [] +synonym: "Snf1 kinase complex" NARROW [] +synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] +synonym: "SNF1/AMPK protein kinase complex" NARROW [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902911 ! protein kinase complex + +[Term] +id: GO:0031589 +name: cell-substrate adhesion +namespace: biological_process +def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0031590 +name: wybutosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037] +synonym: "wybutosine metabolism" EXACT [] +synonym: "yW metabolic process" EXACT [] +synonym: "yW metabolism" EXACT [] +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:0031591 +name: wybutosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037] +comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. +synonym: "yW biosynthesis" EXACT [] +synonym: "yW biosynthetic process" EXACT [] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0031590 ! wybutosine metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901659 ! glycosyl compound biosynthetic process + +[Term] +id: GO:0031592 +name: centrosomal corona +namespace: cellular_component +def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] +comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0031593 +name: polyubiquitin modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ubiquitination of the target protein." [GOC:pg] +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0031594 +name: neuromuscular junction +namespace: cellular_component +def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] +comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. +synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] +synonym: "NMJ" RELATED [GOC:ha] +xref: NIF_Subcellular:sao1124888485 +xref: Wikipedia:Neuromuscular_junction +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0031595 +name: nuclear proteasome complex +namespace: cellular_component +def: "A proteasome found in the nucleus of a cell." [GOC:mah] +is_a: GO:0000502 ! proteasome complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0031596 +name: obsolete ER proteasome complex +namespace: cellular_component +def: "OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031597 +name: cytosolic proteasome complex +namespace: cellular_component +def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0000502 ! proteasome complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0031598 +name: nuclear proteasome regulatory particle +namespace: cellular_component +def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0005838 ! proteasome regulatory particle +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031595 ! nuclear proteasome complex + +[Term] +id: GO:0031599 +name: obsolete ER proteasome regulatory particle +namespace: cellular_component +def: "OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031600 +name: cytosolic proteasome regulatory particle +namespace: cellular_component +def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0005838 ! proteasome regulatory particle +relationship: part_of GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0031601 +name: nuclear proteasome core complex +namespace: cellular_component +def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0005839 ! proteasome core complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031595 ! nuclear proteasome complex + +[Term] +id: GO:0031602 +name: obsolete ER proteasome core complex +namespace: cellular_component +def: "OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031603 +name: cytosolic proteasome core complex +namespace: cellular_component +def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0005839 ! proteasome core complex +relationship: part_of GO:0031597 ! cytosolic proteasome complex + +[Term] +id: GO:0031604 +name: nuclear proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031601 ! nuclear proteasome core complex + +[Term] +id: GO:0031605 +name: obsolete ER proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031606 +name: cytosolic proteasome core complex, alpha-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex +relationship: part_of GO:0031603 ! cytosolic proteasome core complex + +[Term] +id: GO:0031607 +name: nuclear proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0019774 ! proteasome core complex, beta-subunit complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031601 ! nuclear proteasome core complex + +[Term] +id: GO:0031608 +name: obsolete ER proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031609 +name: cytosolic proteasome core complex, beta-subunit complex +namespace: cellular_component +def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0019774 ! proteasome core complex, beta-subunit complex +relationship: part_of GO:0031603 ! cytosolic proteasome core complex + +[Term] +id: GO:0031610 +name: nuclear proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle + +[Term] +id: GO:0031611 +name: obsolete ER proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031612 +name: cytosolic proteasome regulatory particle, base subcomplex +namespace: cellular_component +def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex +relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle + +[Term] +id: GO:0031613 +name: nuclear proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] +is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle + +[Term] +id: GO:0031614 +name: obsolete ER proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] +comment: This term was made obsolete because there is no evidence in the literature of its existence. +is_obsolete: true + +[Term] +id: GO:0031615 +name: cytosolic proteasome regulatory particle, lid subcomplex +namespace: cellular_component +def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu] +is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex +relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle + +[Term] +id: GO:0031616 +name: spindle pole centrosome +namespace: cellular_component +def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] +is_a: GO:0005813 ! centrosome +relationship: part_of GO:0000922 ! spindle pole + +[Term] +id: GO:0031617 +name: NMS complex +namespace: cellular_component +def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] +synonym: "KMN kinetochore network" EXACT [] +synonym: "KNL-1-Mis12-Ndc80" EXACT [] +synonym: "Ndc80-MIND-Spc7 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0031619 +name: homologous chromosome orientation involved in meiotic metaphase I plate congression +namespace: biological_process +def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] +synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb] +synonym: "homologous chromosome orientation during meiosis I" RELATED [] +is_a: GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore +relationship: part_of GO:0043060 ! meiotic metaphase I plate congression + +[Term] +id: GO:0031620 +name: regulation of fever generation +namespace: biological_process +def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] +synonym: "regulation of pyrexia" EXACT [] +is_a: GO:0002673 ! regulation of acute inflammatory response +is_a: GO:0031650 ! regulation of heat generation +relationship: regulates GO:0001660 ! fever generation + +[Term] +id: GO:0031621 +name: negative regulation of fever generation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] +synonym: "down regulation of fever" EXACT [] +synonym: "down-regulation of fever" EXACT [] +synonym: "downregulation of fever" EXACT [] +synonym: "inhibition of fever" NARROW [] +synonym: "negative regulation of pyrexia" EXACT [] +is_a: GO:0002674 ! negative regulation of acute inflammatory response +is_a: GO:0031620 ! regulation of fever generation +is_a: GO:0031651 ! negative regulation of heat generation +relationship: negatively_regulates GO:0001660 ! fever generation + +[Term] +id: GO:0031622 +name: positive regulation of fever generation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add] +synonym: "activation of fever" NARROW [] +synonym: "positive regulation of pyrexia" EXACT [] +synonym: "stimulation of fever" NARROW [] +synonym: "up regulation of fever" EXACT [] +synonym: "up-regulation of fever" EXACT [] +synonym: "upregulation of fever" EXACT [] +is_a: GO:0002675 ! positive regulation of acute inflammatory response +is_a: GO:0031620 ! regulation of fever generation +is_a: GO:0031652 ! positive regulation of heat generation +relationship: positively_regulates GO:0001660 ! fever generation + +[Term] +id: GO:0031623 +name: receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0031624 +name: ubiquitin conjugating enzyme binding +namespace: molecular_function +def: "Binding to a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] +is_a: GO:0044390 ! ubiquitin-like protein conjugating enzyme binding + +[Term] +id: GO:0031625 +name: ubiquitin protein ligase binding +namespace: molecular_function +def: "Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] +synonym: "ubiquitin ligase binding" EXACT [] +is_a: GO:0044389 ! ubiquitin-like protein ligase binding + +[Term] +id: GO:0031626 +name: beta-endorphin binding +namespace: molecular_function +def: "Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] +is_a: GO:0042165 ! neurotransmitter binding +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0031627 +name: telomeric loop formation +namespace: biological_process +def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214] +synonym: "T loop biosynthesis" EXACT [] +synonym: "T loop formation" EXACT [] +synonym: "t-loop biosynthesis" EXACT [] +synonym: "t-loop formation" EXACT [] +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0031628 +name: opioid receptor binding +namespace: molecular_function +def: "Binding to an opioid receptor." [GOC:nln] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031629 +name: synaptic vesicle fusion to presynaptic active zone membrane +namespace: biological_process +def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] +subset: goslim_synapse +synonym: "synaptic vesicle fusion" BROAD [] +synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT [] +synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT [] +is_a: GO:0048499 ! synaptic vesicle membrane organization +is_a: GO:0099500 ! vesicle fusion to plasma membrane +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0031630 +name: regulation of synaptic vesicle fusion to presynaptic active zone membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +subset: goslim_synapse +synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] +synonym: "regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization +relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane + +[Term] +id: GO:0031631 +name: negative regulation of synaptic vesicle fusion to presynaptic active zone membrane +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +synonym: "down regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] +synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] +synonym: "down-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] +synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] +synonym: "downregulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] +synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] +synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" BROAD [] +synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane" EXACT [] +synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic membrane" BROAD [] +synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane +is_a: GO:1901633 ! negative regulation of synaptic vesicle membrane organization +is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis +relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane + +[Term] +id: GO:0031632 +name: positive regulation of synaptic vesicle fusion to presynaptic active zone membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] +synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW [] +synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "positive regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] +synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW [] +synonym: "up regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] +synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "up-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] +synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane +is_a: GO:1901634 ! positive regulation of synaptic vesicle membrane organization +relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane + +[Term] +id: GO:0031633 +name: xanthophore +namespace: cellular_component +def: "A chromatophore containing yellow pigment." [ISBN:0395825172] +comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. +is_a: GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0031634 +name: replication fork barrier binding +namespace: molecular_function +def: "Binding to replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0031635 +name: adenylate cyclase-inhibiting opioid receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] +synonym: "inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:mah] +synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0038003 ! G protein-coupled opioid receptor signaling pathway + +[Term] +id: GO:0031637 +name: regulation of neuronal synaptic plasticity in response to neurotrophin +namespace: biological_process +def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078] +synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT [] +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0031638 +name: zymogen activation +namespace: biological_process +def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] +subset: goslim_chembl +synonym: "zymogen activation by proteolytic cleavage" EXACT [] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0031639 +name: plasminogen activation +namespace: biological_process +def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] +subset: goslim_chembl +synonym: "cleavage of plasminogen to plasmin" EXACT [] +is_a: GO:0031638 ! zymogen activation + +[Term] +id: GO:0031640 +name: killing of cells of another organism +namespace: biological_process +alt_id: GO:0001908 +def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] +subset: goslim_pir +synonym: "killing of cells of other organism" EXACT [] +is_a: GO:0001906 ! cell killing +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0031641 +name: regulation of myelination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051960 ! regulation of nervous system development +relationship: regulates GO:0042552 ! myelination + +[Term] +id: GO:0031642 +name: negative regulation of myelination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +synonym: "down regulation of myelination" EXACT [] +synonym: "down-regulation of myelination" EXACT [] +synonym: "downregulation of myelination" EXACT [] +synonym: "inhibition of myelination" NARROW [] +is_a: GO:0031641 ! regulation of myelination +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0042552 ! myelination + +[Term] +id: GO:0031643 +name: positive regulation of myelination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] +synonym: "activation of myelination" NARROW [] +synonym: "stimulation of myelination" NARROW [] +synonym: "up regulation of myelination" EXACT [] +synonym: "up-regulation of myelination" EXACT [] +synonym: "upregulation of myelination" EXACT [] +is_a: GO:0031641 ! regulation of myelination +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0042552 ! myelination + +[Term] +id: GO:0031644 +name: regulation of nervous system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of neurological system process" EXACT [] +synonym: "regulation of neurophysiological process" EXACT [] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0050877 ! nervous system process + +[Term] +id: GO:0031645 +name: negative regulation of nervous system process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of neurological process" EXACT [] +synonym: "down-regulation of neurological process" EXACT [] +synonym: "downregulation of neurological process" EXACT [] +synonym: "inhibition of neurological process" NARROW [] +synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of neurological system process" EXACT [] +synonym: "negative regulation of neurophysiological process" EXACT [] +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050877 ! nervous system process + +[Term] +id: GO:0031646 +name: positive regulation of nervous system process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of neurological process" NARROW [] +synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of neurological system process" EXACT [] +synonym: "positive regulation of neurophysiological process" EXACT [] +synonym: "stimulation of neurological process" NARROW [] +synonym: "up regulation of neurological process" EXACT [] +synonym: "up-regulation of neurological process" EXACT [] +synonym: "upregulation of neurological process" EXACT [] +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050877 ! nervous system process + +[Term] +id: GO:0031647 +name: regulation of protein stability +namespace: biological_process +def: "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] +subset: goslim_pir +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0031648 +name: protein destabilization +namespace: biological_process +def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] +synonym: "negative regulation of protein stability" EXACT [] +synonym: "protein destabilisation" EXACT [GOC:ah] +is_a: GO:0031647 ! regulation of protein stability + +[Term] +id: GO:0031649 +name: heat generation +namespace: biological_process +def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0031650 +name: regulation of heat generation +namespace: biological_process +def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031651 +name: negative regulation of heat generation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of heat generation" EXACT [] +synonym: "down-regulation of heat generation" EXACT [] +synonym: "downregulation of heat generation" EXACT [] +synonym: "inhibition of heat generation" NARROW [] +is_a: GO:0031650 ! regulation of heat generation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031652 +name: positive regulation of heat generation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of heat generation" NARROW [] +synonym: "stimulation of heat generation" NARROW [] +synonym: "up regulation of heat generation" EXACT [] +synonym: "up-regulation of heat generation" EXACT [] +synonym: "upregulation of heat generation" EXACT [] +is_a: GO:0031650 ! regulation of heat generation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0031649 ! heat generation + +[Term] +id: GO:0031653 +name: heat dissipation +namespace: biological_process +def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0031654 +name: regulation of heat dissipation +namespace: biological_process +def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031655 +name: negative regulation of heat dissipation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of heat dissipation" EXACT [] +synonym: "down-regulation of heat dissipation" EXACT [] +synonym: "downregulation of heat dissipation" EXACT [] +synonym: "inhibition of heat dissipation" NARROW [] +is_a: GO:0031654 ! regulation of heat dissipation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031656 +name: positive regulation of heat dissipation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of heat dissipation" NARROW [] +synonym: "stimulation of heat dissipation" NARROW [] +synonym: "up regulation of heat dissipation" EXACT [] +synonym: "up-regulation of heat dissipation" EXACT [] +synonym: "upregulation of heat dissipation" EXACT [] +is_a: GO:0031654 ! regulation of heat dissipation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0031653 ! heat dissipation + +[Term] +id: GO:0031657 +name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle, GOC:pr] +comment: The term has been obsoleted because it represents a GO-CAM model. +synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] +is_obsolete: true + +[Term] +id: GO:0031658 +name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] +comment: The term has been obsoleted because it represents a GO-CAM model. +synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] +is_obsolete: true + +[Term] +id: GO:0031659 +name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] +comment: The term has been obsoleted because it represents a GO-CAM model. +synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] +synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] +is_obsolete: true + +[Term] +id: GO:0031660 +name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] +comment: This term was obsoleted because it is a MF represented as a BP. +synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] +is_obsolete: true +consider: GO:0010389 + +[Term] +id: GO:0031661 +name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] +comment: This term was obsoleted because it is a MF represented as a BP. +synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] +synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] +synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] +is_obsolete: true +consider: GO:0010389 + +[Term] +id: GO:0031663 +name: lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975] +synonym: "lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "LPS-mediated signaling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway +relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide + +[Term] +id: GO:0031664 +name: regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "regulation of LPS-mediated signaling pathway" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031665 +name: negative regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "negative regulation of LPS-mediated signaling pathway" EXACT [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway +is_a: GO:0032102 ! negative regulation of response to external stimulus +relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031666 +name: positive regulation of lipopolysaccharide-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] +synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] +synonym: "positive regulation of LPS-mediated signaling pathway" EXACT [] +synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW [] +synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway +is_a: GO:0032103 ! positive regulation of response to external stimulus +relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway + +[Term] +id: GO:0031667 +name: response to nutrient levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] +is_a: GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0031668 +name: cellular response to extracellular stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] +is_a: GO:0007154 ! cell communication +is_a: GO:0009991 ! response to extracellular stimulus +is_a: GO:0051716 ! cellular response to stimulus +is_a: GO:0071496 ! cellular response to external stimulus + +[Term] +id: GO:0031669 +name: cellular response to nutrient levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0031670 +name: cellular response to nutrient +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] +is_a: GO:0007584 ! response to nutrient +is_a: GO:0031669 ! cellular response to nutrient levels +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0031671 +name: primary cell septum biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] +is_a: GO:0044085 ! cellular component biogenesis +is_a: GO:1902410 ! mitotic cytokinetic process +relationship: part_of GO:0140278 ! mitotic division septum assembly + +[Term] +id: GO:0031672 +name: A band +namespace: cellular_component +def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] +synonym: "A disc" EXACT [] +synonym: "anisotropic disc" EXACT [] +synonym: "Q disc" EXACT [] +synonym: "transverse disc" EXACT [] +xref: Wikipedia:Sarcomere#bands +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0031673 +name: H zone +namespace: cellular_component +def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] +synonym: "H band" EXACT [] +synonym: "H disc" EXACT [] +xref: Wikipedia:Sarcomere#bands +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031672 ! A band + +[Term] +id: GO:0031674 +name: I band +namespace: cellular_component +def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] +synonym: "I disc" EXACT [] +synonym: "isotropic disc" EXACT [] +synonym: "J disc" EXACT [] +xref: Wikipedia:Sarcomere#bands +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030017 ! sarcomere + +[Term] +id: GO:0031676 +name: plasma membrane-derived thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] +synonym: "plasma membrane thylakoid membrane" EXACT [] +is_a: GO:0042651 ! thylakoid membrane +is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0030075 ! bacterial thylakoid + +[Term] +id: GO:0031679 +name: NADH dehydrogenase (plastoquinone) activity +namespace: molecular_function +alt_id: GO:0030024 +def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] +synonym: "NADH:plastoquinone reductase activity" EXACT [] +is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity + +[Term] +id: GO:0031680 +name: G-protein beta/gamma-subunit complex +namespace: cellular_component +def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] +comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. +synonym: "G-beta/G-gamma complex" EXACT [] +synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0031681 +name: G-protein beta-subunit binding +namespace: molecular_function +def: "Binding to a G-protein beta subunit." [GOC:mah] +synonym: "G-beta protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031682 +name: G-protein gamma-subunit binding +namespace: molecular_function +def: "Binding to a G-protein gamma subunit." [GOC:mah] +synonym: "G-gamma protein subunit binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031683 +name: G-protein beta/gamma-subunit complex binding +namespace: molecular_function +def: "Binding to a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0031684 +name: obsolete heterotrimeric G-protein complex cycle +namespace: biological_process +def: "OBSOLETE. The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln] +comment: The reason for obsoleting is that it is an arbitrary grouping term that groups the molecular functions required for the G-protein complex cycle, and this is not a bona fide biological process. +is_obsolete: true + +[Term] +id: GO:0031685 +name: adenosine receptor binding +namespace: molecular_function +def: "Binding to an adenosine receptor." [GOC:mah, GOC:nln] +synonym: "adenosine receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031686 +name: A1 adenosine receptor binding +namespace: molecular_function +def: "Binding to an A1 adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A1 adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031687 +name: A2A adenosine receptor binding +namespace: molecular_function +def: "Binding to an A2A adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A2A adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031688 +name: A2B adenosine receptor binding +namespace: molecular_function +def: "Binding to an A2B adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A2B adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031689 +name: A3 adenosine receptor binding +namespace: molecular_function +def: "Binding to an A3 adenosine receptor." [GOC:mah, GOC:nln] +synonym: "A3 adenosine receptor ligand" NARROW [] +is_a: GO:0031685 ! adenosine receptor binding + +[Term] +id: GO:0031690 +name: adrenergic receptor binding +namespace: molecular_function +def: "Binding to an adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "adrenergic receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031691 +name: alpha-1A adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1A adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031692 +name: alpha-1B adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1B adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031693 +name: alpha-1D adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-1D adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031694 +name: alpha-2A adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2A adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031695 +name: alpha-2B adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2B adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031696 +name: alpha-2C adrenergic receptor binding +namespace: molecular_function +def: "Binding to an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "alpha-2C adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031697 +name: beta-1 adrenergic receptor binding +namespace: molecular_function +def: "Binding to a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-1 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031698 +name: beta-2 adrenergic receptor binding +namespace: molecular_function +def: "Binding to a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-2 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031699 +name: beta-3 adrenergic receptor binding +namespace: molecular_function +def: "Binding to a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] +synonym: "beta-3 adrenergic receptor ligand" NARROW [] +is_a: GO:0031690 ! adrenergic receptor binding + +[Term] +id: GO:0031700 +name: adrenomedullin receptor binding +namespace: molecular_function +def: "Binding to an adrenomedullin receptor." [GOC:mah, GOC:nln] +synonym: "adrenomedullin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031701 +name: angiotensin receptor binding +namespace: molecular_function +def: "Binding to an angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "angiotensin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031702 +name: type 1 angiotensin receptor binding +namespace: molecular_function +def: "Binding to a type 1 angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "AT1 receptor binding" EXACT [] +synonym: "type 1 angiotensin receptor ligand" NARROW [] +is_a: GO:0031701 ! angiotensin receptor binding + +[Term] +id: GO:0031703 +name: type 2 angiotensin receptor binding +namespace: molecular_function +def: "Binding to a type 2 angiotensin receptor." [GOC:mah, GOC:nln] +synonym: "AT2 receptor binding" EXACT [] +synonym: "type 2 angiotensin receptor ligand" NARROW [] +is_a: GO:0031701 ! angiotensin receptor binding + +[Term] +id: GO:0031704 +name: apelin receptor binding +namespace: molecular_function +alt_id: GO:0042569 +def: "Binding to an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] +synonym: "apelin receptor ligand" NARROW [] +synonym: "APJ receptor binding" EXACT [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031705 +name: bombesin receptor binding +namespace: molecular_function +def: "Binding to a bombesin receptor." [GOC:mah, GOC:nln] +synonym: "bombesin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031706 +name: subtype 3 bombesin receptor binding +namespace: molecular_function +def: "Binding to a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] +synonym: "subtype 3 bombesin receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031707 +name: endothelin A receptor binding +namespace: molecular_function +def: "Binding to an endothelin A receptor." [GOC:mah, GOC:nln] +synonym: "endothelin A receptor ligand" NARROW [] +synonym: "endothelin-1 receptor binding" EXACT [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031708 +name: endothelin B receptor binding +namespace: molecular_function +def: "Binding to an endothelin B receptor." [GOC:mah, GOC:nln] +synonym: "endothelin B receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031709 +name: gastrin-releasing peptide receptor binding +namespace: molecular_function +def: "Binding to a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] +synonym: "gastrin-releasing peptide receptor ligand" NARROW [] +synonym: "GRP receptor binding" EXACT [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031710 +name: neuromedin B receptor binding +namespace: molecular_function +def: "Binding to a neuromedin B receptor." [GOC:mah, GOC:nln] +synonym: "neuromedin B receptor ligand" NARROW [] +is_a: GO:0031705 ! bombesin receptor binding + +[Term] +id: GO:0031711 +name: bradykinin receptor binding +namespace: molecular_function +def: "Binding to a bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "bradykinin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031712 +name: B1 bradykinin receptor binding +namespace: molecular_function +def: "Binding to a B1 bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "B1 bradykinin receptor ligand" NARROW [] +is_a: GO:0031711 ! bradykinin receptor binding + +[Term] +id: GO:0031713 +name: B2 bradykinin receptor binding +namespace: molecular_function +def: "Binding to a B2 bradykinin receptor." [GOC:mah, GOC:nln] +synonym: "B2 bradykinin receptor ligand" NARROW [] +is_a: GO:0031711 ! bradykinin receptor binding + +[Term] +id: GO:0031714 +name: C5a anaphylatoxin chemotactic receptor binding +namespace: molecular_function +def: "Binding to a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] +synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031715 +name: C5L2 anaphylatoxin chemotactic receptor binding +namespace: molecular_function +def: "Binding to a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] +synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] +is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding + +[Term] +id: GO:0031716 +name: calcitonin receptor binding +namespace: molecular_function +def: "Binding to a calcitonin receptor." [GOC:mah, GOC:nln] +synonym: "calcitonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031717 +name: cannabinoid receptor binding +namespace: molecular_function +def: "Binding to a cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "cannabinoid receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031718 +name: type 1 cannabinoid receptor binding +namespace: molecular_function +def: "Binding to a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "type 1 cannabinoid receptor ligand" NARROW [] +is_a: GO:0031717 ! cannabinoid receptor binding + +[Term] +id: GO:0031719 +name: type 2 cannabinoid receptor binding +namespace: molecular_function +def: "Binding to a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] +synonym: "type 2 cannabinoid receptor ligand" NARROW [] +is_a: GO:0031717 ! cannabinoid receptor binding + +[Term] +id: GO:0031720 +name: haptoglobin binding +namespace: molecular_function +def: "Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0031721 +name: hemoglobin alpha binding +namespace: molecular_function +def: "Binding to a hemoglobin alpha chain." [GOC:mah] +is_a: GO:0030492 ! hemoglobin binding + +[Term] +id: GO:0031722 +name: hemoglobin beta binding +namespace: molecular_function +def: "Binding to a hemoglobin beta chain." [GOC:mah] +is_a: GO:0030492 ! hemoglobin binding + +[Term] +id: GO:0031723 +name: CXCR4 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CXCR4 chemokine receptor ligand" NARROW [] +synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031724 +name: CXCR5 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CXCR5 chemokine receptor ligand" NARROW [] +synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031725 +name: CXCR6 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "bonzo receptor binding" EXACT [] +synonym: "CXCR6 chemokine receptor ligand" NARROW [] +synonym: "STRL33 receptor binding" EXACT [] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0031726 +name: CCR1 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR1 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR1 chemokine receptor ligand" NARROW [] +synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031727 +name: CCR2 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR2 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR2 chemokine receptor ligand" NARROW [] +synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031728 +name: CCR3 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR3 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR3 chemokine receptor ligand" NARROW [] +synonym: "eosinophil eotaxin receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031729 +name: CCR4 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR4 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR4 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031730 +name: CCR5 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR5 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR5 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031731 +name: CCR6 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR6 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR6 chemokine receptor ligand" NARROW [] +synonym: "LARC receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031732 +name: CCR7 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR7 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR7 chemokine receptor ligand" NARROW [] +synonym: "MIP-3 beta receptor binding" EXACT [] +synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031733 +name: CCR8 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR8 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR8 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031734 +name: CCR9 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR9 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR9 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031735 +name: CCR10 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR10 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR10 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031736 +name: CCR11 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR11 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CCR11 chemokine receptor ligand" NARROW [] +is_a: GO:0048020 ! CCR chemokine receptor binding + +[Term] +id: GO:0031737 +name: CX3C chemokine receptor binding +namespace: molecular_function +def: "Binding to a CX3C chemokine receptor." [GOC:mah, GOC:nln] +synonym: "CX3C chemokine receptor ligand" NARROW [] +synonym: "fractalkine receptor binding" EXACT [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0031738 +name: XCR1 chemokine receptor binding +namespace: molecular_function +def: "Binding to a XCR1 chemokine receptor." [GOC:mah, GOC:nln] +synonym: "lymphotactin receptor binding" EXACT [] +synonym: "XCR1 chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0031739 +name: cholecystokinin receptor binding +namespace: molecular_function +def: "Binding to a cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "cholecystokinin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031740 +name: type A cholecystokinin receptor binding +namespace: molecular_function +def: "Binding to a type A cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "type A cholecystokinin receptor ligand" NARROW [] +is_a: GO:0031739 ! cholecystokinin receptor binding + +[Term] +id: GO:0031741 +name: type B gastrin/cholecystokinin receptor binding +namespace: molecular_function +def: "Binding to a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] +synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] +is_a: GO:0031739 ! cholecystokinin receptor binding + +[Term] +id: GO:0031745 +name: cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Binding to a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031746 +name: type 1 cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Binding to a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0031745 ! cysteinyl leukotriene receptor binding + +[Term] +id: GO:0031747 +name: type 2 cysteinyl leukotriene receptor binding +namespace: molecular_function +def: "Binding to a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] +is_a: GO:0031745 ! cysteinyl leukotriene receptor binding + +[Term] +id: GO:0031748 +name: D1 dopamine receptor binding +namespace: molecular_function +def: "Binding to a D1 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D1 dopamine receptor ligand" NARROW [] +synonym: "D1A dopamine receptor binding" EXACT [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031749 +name: D2 dopamine receptor binding +namespace: molecular_function +def: "Binding to a D2 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D2 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031750 +name: D3 dopamine receptor binding +namespace: molecular_function +def: "Binding to a D3 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D3 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031751 +name: D4 dopamine receptor binding +namespace: molecular_function +def: "Binding to a D4 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D4 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031752 +name: D5 dopamine receptor binding +namespace: molecular_function +def: "Binding to a D5 dopamine receptor." [GOC:mah, GOC:nln] +synonym: "D1B dopamine receptor binding" EXACT [] +synonym: "D5 dopamine receptor ligand" NARROW [] +is_a: GO:0050780 ! dopamine receptor binding + +[Term] +id: GO:0031753 +name: endothelial differentiation G protein-coupled receptor binding +namespace: molecular_function +def: "Binding to an endothelial differentiation G protein-coupled receptor." [GOC:mah, GOC:nln] +synonym: "endothelial differentiation G-protein coupled receptor binding" EXACT [] +synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031754 +name: Edg-1 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Binding to an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031755 +name: Edg-2 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Binding to an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA1 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031756 +name: Edg-3 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Binding to an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031757 +name: Edg-4 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Binding to an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA2 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031758 +name: Edg-5 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Binding to an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031759 +name: Edg-6 sphingosine 1-phosphate receptor binding +namespace: molecular_function +def: "Binding to an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] +synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031760 +name: Edg-7 lysophosphatidic acid receptor binding +namespace: molecular_function +def: "Binding to an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] +synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] +synonym: "LPA3 receptor binding" EXACT [] +is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding + +[Term] +id: GO:0031761 +name: fMet-Leu-Phe receptor binding +namespace: molecular_function +def: "Binding to a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] +synonym: "fMet-Leu-Phe receptor ligand" NARROW [] +synonym: "N-formyl peptide receptor binding" EXACT [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031762 +name: follicle-stimulating hormone receptor binding +namespace: molecular_function +def: "Binding to a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln] +synonym: "follicle stimulating hormone receptor binding" EXACT [] +synonym: "follicle stimulating hormone receptor ligand" NARROW [] +synonym: "FSH receptor binding" EXACT [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031763 +name: galanin receptor binding +namespace: molecular_function +def: "Binding to a galanin receptor." [GOC:mah, GOC:nln] +synonym: "galanin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031764 +name: type 1 galanin receptor binding +namespace: molecular_function +def: "Binding to a type 1 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031765 +name: type 2 galanin receptor binding +namespace: molecular_function +def: "Binding to a type 2 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031766 +name: type 3 galanin receptor binding +namespace: molecular_function +def: "Binding to a type 3 galanin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 galanin receptor ligand" NARROW [] +is_a: GO:0031763 ! galanin receptor binding + +[Term] +id: GO:0031767 +name: gastric inhibitory polypeptide receptor binding +namespace: molecular_function +def: "Binding to a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031768 +name: ghrelin receptor binding +namespace: molecular_function +def: "Binding to a ghrelin receptor." [GOC:mah, GOC:nln] +synonym: "ghrelin receptor ligand" NARROW [] +synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031769 +name: glucagon receptor binding +namespace: molecular_function +def: "Binding to a glucagon receptor." [GOC:mah, GOC:nln] +synonym: "glucagon receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031770 +name: growth hormone-releasing hormone receptor binding +namespace: molecular_function +def: "Binding to a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] +synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031771 +name: type 1 hypocretin receptor binding +namespace: molecular_function +def: "Binding to a type 1 hypocretin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 hypocretin receptor ligand" NARROW [] +synonym: "type 1 orexin receptor binding" EXACT [] +is_a: GO:0042324 ! hypocretin receptor binding + +[Term] +id: GO:0031772 +name: type 2 hypocretin receptor binding +namespace: molecular_function +def: "Binding to a type 2 hypocretin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 hypocretin receptor ligand" NARROW [] +synonym: "type 2 orexin receptor binding" EXACT [] +is_a: GO:0042324 ! hypocretin receptor binding + +[Term] +id: GO:0031773 +name: kisspeptin receptor binding +namespace: molecular_function +def: "Binding to a kisspeptin receptor." [GOC:mah, GOC:nln] +synonym: "G-protein coupled receptor 54 binding" EXACT [] +synonym: "hOT7T175 receptor binding" EXACT [] +synonym: "hypogonadotropin-1 receptor binding" EXACT [] +synonym: "KiSS-1 receptor binding" EXACT [] +synonym: "kisspeptin receptor ligand" NARROW [] +synonym: "metastin receptor binding" EXACT [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031774 +name: leukotriene receptor binding +namespace: molecular_function +def: "Binding to a leukotriene receptor." [GOC:mah, GOC:nln] +synonym: "leukotriene receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031775 +name: lutropin-choriogonadotropic hormone receptor binding +namespace: molecular_function +def: "Binding to a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] +synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031776 +name: melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Binding to a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031777 +name: type 1 melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Binding to a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0031776 ! melanin-concentrating hormone receptor binding + +[Term] +id: GO:0031778 +name: type 2 melanin-concentrating hormone receptor binding +namespace: molecular_function +def: "Binding to a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] +is_a: GO:0031776 ! melanin-concentrating hormone receptor binding + +[Term] +id: GO:0031779 +name: melanocortin receptor binding +namespace: molecular_function +def: "Binding to a melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "melanocortin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031780 +name: corticotropin hormone receptor binding +namespace: molecular_function +alt_id: GO:0071856 +def: "Binding to a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] +synonym: "ACTH receptor binding" EXACT [] +synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] +synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb] +synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph] +synonym: "corticotropin receptor binding" EXACT [GOC:bf] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031781 +name: type 3 melanocortin receptor binding +namespace: molecular_function +def: "Binding to a type 3 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031782 +name: type 4 melanocortin receptor binding +namespace: molecular_function +def: "Binding to a type 4 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 4 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031783 +name: type 5 melanocortin receptor binding +namespace: molecular_function +def: "Binding to a type 5 melanocortin receptor." [GOC:mah, GOC:nln] +synonym: "type 5 melanocortin receptor ligand" NARROW [] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0031784 +name: melatonin receptor binding +namespace: molecular_function +def: "Binding to a melatonin receptor." [GOC:mah, GOC:nln] +synonym: "melatonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031785 +name: type 1A melatonin receptor binding +namespace: molecular_function +def: "Binding to a type 1A melatonin receptor." [GOC:mah, GOC:nln] +synonym: "type 1A melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031786 +name: type 1B melatonin receptor binding +namespace: molecular_function +def: "Binding to a type 1B melatonin receptor." [GOC:mah, GOC:nln] +synonym: "type 1B melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031787 +name: H9 melatonin receptor binding +namespace: molecular_function +def: "Binding to a H9 melatonin receptor." [GOC:mah, GOC:nln] +synonym: "H9 melatonin receptor ligand" NARROW [] +is_a: GO:0031784 ! melatonin receptor binding + +[Term] +id: GO:0031788 +name: motilin receptor binding +namespace: molecular_function +def: "Binding to a motilin receptor." [GOC:mah, GOC:nln] +synonym: "motilin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031789 +name: G protein-coupled acetylcholine receptor binding +namespace: molecular_function +alt_id: GO:0031790 +alt_id: GO:0031791 +alt_id: GO:0031792 +alt_id: GO:0031793 +alt_id: GO:0031794 +def: "Binding to a G protein-coupled acetylcholine receptor." [GOC:bf, GOC:mah, GOC:nln] +synonym: "G-protein coupled acetylcholine receptor binding" EXACT [] +synonym: "M1 muscarinic acetylcholine receptor binding" NARROW [] +synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] +synonym: "M2 muscarinic acetylcholine receptor binding" NARROW [] +synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] +synonym: "M3 muscarinic acetylcholine receptor binding" NARROW [] +synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] +synonym: "M4 muscarinic acetylcholine receptor binding" NARROW [] +synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] +synonym: "M5 muscarinic acetylcholine receptor binding" NARROW [] +synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] +synonym: "muscarinic acetylcholine receptor binding" EXACT [GOC:bf] +synonym: "muscarinic acetylcholine receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031795 +name: G protein-coupled GABA receptor binding +namespace: molecular_function +def: "Binding to a G protein-coupled (metabotropic) GABA receptor." [GOC:mah, GOC:nln] +synonym: "G-protein coupled GABA receptor binding" EXACT [] +synonym: "GABAB receptor binding" EXACT [] +synonym: "metabotropic GABA receptor binding" EXACT [GOC:bf] +synonym: "metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding +is_a: GO:0050811 ! GABA receptor binding + +[Term] +id: GO:0031796 +name: type 1 metabotropic GABA receptor binding +namespace: molecular_function +def: "Binding to a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] +synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0031795 ! G protein-coupled GABA receptor binding + +[Term] +id: GO:0031797 +name: type 2 metabotropic GABA receptor binding +namespace: molecular_function +def: "Binding to a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] +synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] +is_a: GO:0031795 ! G protein-coupled GABA receptor binding + +[Term] +id: GO:0031798 +name: type 1 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031799 +name: type 2 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031800 +name: type 3 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031801 +name: type 4 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031802 +name: type 5 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031803 +name: type 6 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031804 +name: type 7 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031805 +name: type 8 metabotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] +synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] +is_a: GO:0035256 ! G protein-coupled glutamate receptor binding + +[Term] +id: GO:0031806 +name: G protein-coupled histamine receptor binding +namespace: molecular_function +def: "Binding to a G protein-coupled (metabotropic) histamine receptor." [GOC:mah, GOC:nln, PMID:12679144] +synonym: "G-protein coupled histamine receptor binding" EXACT [] +synonym: "metabotropic histamine receptor binding" EXACT [GOC:bf] +synonym: "metabotropic histamine receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031807 +name: H1 histamine receptor binding +namespace: molecular_function +def: "Binding to a H1 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H1 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! G protein-coupled histamine receptor binding + +[Term] +id: GO:0031808 +name: H2 histamine receptor binding +namespace: molecular_function +def: "Binding to a H2 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H2 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! G protein-coupled histamine receptor binding + +[Term] +id: GO:0031809 +name: H3 histamine receptor binding +namespace: molecular_function +def: "Binding to a H3 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H3 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! G protein-coupled histamine receptor binding + +[Term] +id: GO:0031810 +name: H4 histamine receptor binding +namespace: molecular_function +def: "Binding to a H4 histamine receptor." [GOC:mah, GOC:nln] +synonym: "H4 histamine receptor ligand" NARROW [] +is_a: GO:0031806 ! G protein-coupled histamine receptor binding + +[Term] +id: GO:0031811 +name: G protein-coupled nucleotide receptor binding +namespace: molecular_function +def: "Binding to a G protein-coupled (metabotropic) nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "G-protein coupled nucleotide receptor binding" EXACT [] +synonym: "metabotropic nucleotide receptor binding" EXACT [GOC:bf] +synonym: "metabotropic nucleotide receptor ligand" NARROW [] +synonym: "P2Y receptor binding" EXACT [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031812 +name: P2Y1 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y1 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031813 +name: P2Y2 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y2 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031814 +name: P2Y4 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y4 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031815 +name: P2Y5 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y5 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031816 +name: P2Y6 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y6 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031817 +name: P2Y8 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y8 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031818 +name: P2Y9 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y9 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031819 +name: P2Y10 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y10 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031820 +name: P2Y11 nucleotide receptor binding +namespace: molecular_function +def: "Binding to a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] +synonym: "P2Y11 nucleotide receptor ligand" NARROW [] +is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding + +[Term] +id: GO:0031821 +name: G protein-coupled serotonin receptor binding +namespace: molecular_function +def: "Binding to a metabotropic serotonin receptor." [GOC:mah, GOC:nln] +synonym: "G-protein coupled serotonin receptor binding" EXACT [] +synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] +synonym: "metabotropic serotonin receptor binding" EXACT [GOC:bf] +synonym: "metabotropic serotonin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031822 +name: type 1B serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 1B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] +synonym: "type 1B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031823 +name: type 1D serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 1D serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] +synonym: "type 1D serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031824 +name: type 1E serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 1E serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] +synonym: "type 1E serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031825 +name: type 1F serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 1F serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] +synonym: "type 1F serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031826 +name: type 2A serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 2A serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] +synonym: "type 2A serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031827 +name: type 2B serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 2B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] +synonym: "type 2B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031828 +name: type 2C serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 2C serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] +synonym: "type 2C serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031829 +name: type 4 serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 4 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] +synonym: "type 4 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031830 +name: type 5A serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 5A serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] +synonym: "type 5A serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031831 +name: type 5B serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 5B serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] +synonym: "type 5B serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031832 +name: type 6 serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 6 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] +synonym: "type 6 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031833 +name: type 7 serotonin receptor binding +namespace: molecular_function +def: "Binding to a type 7 serotonin receptor." [GOC:mah, GOC:nln] +synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] +synonym: "type 7 serotonin receptor ligand" NARROW [] +is_a: GO:0031821 ! G protein-coupled serotonin receptor binding + +[Term] +id: GO:0031834 +name: neurokinin receptor binding +namespace: molecular_function +def: "Binding to a neurokinin receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031835 +name: substance P receptor binding +namespace: molecular_function +def: "Binding to a substance P receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-1 receptor binding" EXACT [] +synonym: "substance P receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031836 +name: neuromedin K receptor binding +namespace: molecular_function +def: "Binding to a neuromedin K receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-B receptor binding" EXACT [] +synonym: "neuromedin K receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031837 +name: substance K receptor binding +namespace: molecular_function +def: "Binding to a substance K receptor." [GOC:mah, GOC:nln] +synonym: "neurokinin-A receptor binding" EXACT [] +synonym: "substance K receptor ligand" NARROW [] +is_a: GO:0031834 ! neurokinin receptor binding + +[Term] +id: GO:0031838 +name: haptoglobin-hemoglobin complex +namespace: cellular_component +def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0031839 +name: type 1 neuromedin U receptor binding +namespace: molecular_function +def: "Binding to a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neuromedin U receptor ligand" NARROW [] +is_a: GO:0042922 ! neuromedin U receptor binding + +[Term] +id: GO:0031840 +name: type 2 neuromedin U receptor binding +namespace: molecular_function +def: "Binding to a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] +synonym: "type 2 neuromedin U receptor ligand" NARROW [] +is_a: GO:0042922 ! neuromedin U receptor binding + +[Term] +id: GO:0031841 +name: neuropeptide Y receptor binding +namespace: molecular_function +def: "Binding to a neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "neuropeptide Y receptor ligand" NARROW [] +synonym: "NPY receptor binding" EXACT [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031842 +name: type 1 neuropeptide Y receptor binding +namespace: molecular_function +def: "Binding to a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031843 +name: type 2 neuropeptide Y receptor binding +namespace: molecular_function +def: "Binding to a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031844 +name: type 4 neuropeptide Y receptor binding +namespace: molecular_function +def: "Binding to a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "pancreatic polypeptide receptor binding" EXACT [] +synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031845 +name: type 5 neuropeptide Y receptor binding +namespace: molecular_function +def: "Binding to a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] +synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] +is_a: GO:0031841 ! neuropeptide Y receptor binding + +[Term] +id: GO:0031846 +name: neurotensin receptor binding +namespace: molecular_function +def: "Binding to a neurotensin receptor." [GOC:mah, GOC:nln] +synonym: "neurotensin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031847 +name: type 1 neurotensin receptor binding +namespace: molecular_function +def: "Binding to a type 1 neurotensin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 neurotensin receptor ligand" NARROW [] +is_a: GO:0031846 ! neurotensin receptor binding + +[Term] +id: GO:0031848 +name: protection from non-homologous end joining at telomere +namespace: biological_process +def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah] +synonym: "protection from NHEJ-mediated telomere fusion" EXACT [] +is_a: GO:0043247 ! telomere maintenance in response to DNA damage +relationship: part_of GO:0016233 ! telomere capping + +[Term] +id: GO:0031849 +name: olfactory receptor binding +namespace: molecular_function +def: "Binding to an olfactory receptor." [GOC:mah, GOC:nln] +synonym: "olfactory receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031850 +name: delta-type opioid receptor binding +namespace: molecular_function +def: "Binding to a delta-type opioid receptor." [GOC:mah, GOC:nln] +synonym: "delta-type opioid receptor ligand" NARROW [] +synonym: "enkephalin receptor binding" RELATED [GOC:sl] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031851 +name: kappa-type opioid receptor binding +namespace: molecular_function +def: "Binding to a kappa-type opioid receptor." [GOC:mah, GOC:nln] +synonym: "dynorphin receptor binding" RELATED [] +synonym: "kappa-type opioid receptor ligand" NARROW [GOC:sl] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031852 +name: mu-type opioid receptor binding +namespace: molecular_function +def: "Binding to a mu-type opioid receptor." [GOC:mah, GOC:nln, GOC:sl] +synonym: "morphine receptor binding" RELATED [GOC:sl] +synonym: "mu-type opioid receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031853 +name: nociceptin receptor binding +namespace: molecular_function +def: "Binding to a nociceptin receptor." [GOC:mah, GOC:nln] +synonym: "nociceptin receptor ligand" NARROW [] +is_a: GO:0031628 ! opioid receptor binding + +[Term] +id: GO:0031854 +name: orexigenic neuropeptide QRFP receptor binding +namespace: molecular_function +def: "Binding to an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] +synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031855 +name: oxytocin receptor binding +namespace: molecular_function +def: "Binding to an oxytocin receptor." [GOC:mah, GOC:nln] +synonym: "oxytocin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031856 +name: parathyroid hormone receptor binding +namespace: molecular_function +def: "Binding to a parathyroid hormone receptor." [GOC:mah, GOC:nln] +synonym: "parathyroid hormone receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031857 +name: type 1 parathyroid hormone receptor binding +namespace: molecular_function +def: "Binding to a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] +synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] +is_a: GO:0031856 ! parathyroid hormone receptor binding + +[Term] +id: GO:0031858 +name: pituitary adenylate cyclase-activating polypeptide receptor binding +namespace: molecular_function +def: "Binding to a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "PACAP receptor binding" EXACT [] +synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb] +synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031859 +name: platelet activating factor receptor binding +namespace: molecular_function +def: "Binding to a platelet activating factor receptor." [GOC:mah, GOC:nln] +synonym: "platelet activating factor receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031860 +name: telomeric 3' overhang formation +namespace: biological_process +def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] +synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw] +synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw] +is_a: GO:0022616 ! DNA strand elongation +relationship: part_of GO:0016233 ! telomere capping + +[Term] +id: GO:0031861 +name: prolactin-releasing peptide receptor binding +namespace: molecular_function +def: "Binding to a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] +synonym: "prolactin-releasing peptide receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031862 +name: prostanoid receptor binding +namespace: molecular_function +def: "Binding to a prostanoid receptor." [GOC:mah, GOC:nln] +synonym: "prostanoid receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031863 +name: prostaglandin D2 receptor binding +namespace: molecular_function +def: "Binding to a prostaglandin D2 receptor." [GOC:mah, GOC:nln] +synonym: "prostaglandin D2 receptor ligand" NARROW [] +synonym: "prostanoid DP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031864 +name: EP1 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Binding to an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP1 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031865 +name: EP2 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Binding to an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP2 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031866 +name: EP3 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Binding to an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP3 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031867 +name: EP4 subtype prostaglandin E2 receptor binding +namespace: molecular_function +def: "Binding to an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] +synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] +synonym: "prostanoid EP4 receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031868 +name: prostaglandin F2-alpha receptor binding +namespace: molecular_function +def: "Binding to a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] +synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] +synonym: "prostanoid FP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031869 +name: prostacyclin receptor binding +namespace: molecular_function +def: "Binding to a prostacyclin receptor." [GOC:mah, GOC:nln] +synonym: "prostacyclin receptor ligand" NARROW [] +synonym: "prostanoid IP receptor binding" EXACT [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031870 +name: thromboxane A2 receptor binding +namespace: molecular_function +def: "Binding to a thromboxane A2 receptor." [GOC:mah, GOC:nln] +synonym: "prostanoid TP receptor binding" EXACT [] +synonym: "thromboxane A2 receptor ligand" NARROW [] +is_a: GO:0031862 ! prostanoid receptor binding + +[Term] +id: GO:0031871 +name: proteinase activated receptor binding +namespace: molecular_function +def: "Binding to a proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "proteinase activated receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031872 +name: type 1 proteinase activated receptor binding +namespace: molecular_function +def: "Binding to a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "thrombin receptor binding" EXACT [] +synonym: "type 1 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031873 +name: type 2 proteinase activated receptor binding +namespace: molecular_function +def: "Binding to a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 2 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031874 +name: type 3 proteinase activated receptor binding +namespace: molecular_function +def: "Binding to a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 3 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031875 +name: type 4 proteinase activated receptor binding +namespace: molecular_function +def: "Binding to a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] +synonym: "type 4 proteinase activated receptor ligand" NARROW [] +is_a: GO:0031871 ! proteinase activated receptor binding + +[Term] +id: GO:0031876 +name: secretin receptor binding +namespace: molecular_function +def: "Binding to a secretin receptor." [GOC:mah, GOC:nln] +synonym: "secretin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031877 +name: somatostatin receptor binding +namespace: molecular_function +def: "Binding to a somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "somatostatin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031878 +name: type 1 somatostatin receptor binding +namespace: molecular_function +def: "Binding to a type 1 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 1 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031879 +name: type 2 somatostatin receptor binding +namespace: molecular_function +def: "Binding to a type 2 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 2 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031880 +name: type 3 somatostatin receptor binding +namespace: molecular_function +def: "Binding to a type 3 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 3 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031881 +name: type 4 somatostatin receptor binding +namespace: molecular_function +def: "Binding to a type 4 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 4 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031882 +name: type 5 somatostatin receptor binding +namespace: molecular_function +def: "Binding to a type 5 somatostatin receptor." [GOC:mah, GOC:nln] +synonym: "type 5 somatostatin receptor ligand" NARROW [] +is_a: GO:0031877 ! somatostatin receptor binding + +[Term] +id: GO:0031883 +name: taste receptor binding +namespace: molecular_function +def: "Binding to a taste receptor." [GOC:mah, GOC:nln] +synonym: "taste receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031884 +name: type 1 member 1 taste receptor binding +namespace: molecular_function +def: "Binding to a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] +synonym: "type 1 member 1 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031885 +name: type 1 member 2 taste receptor binding +namespace: molecular_function +def: "Binding to a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] +synonym: "type 1 member 2 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031886 +name: type 1 member 3 taste receptor binding +namespace: molecular_function +def: "Binding to a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] +synonym: "sweet taste receptor binding" EXACT [] +synonym: "type 1 member 3 taste receptor ligand" NARROW [] +is_a: GO:0031883 ! taste receptor binding + +[Term] +id: GO:0031887 +name: lipid droplet transport along microtubule +namespace: biological_process +def: "The directed movement of a lipid droplet along a microtubule, mediated by motor proteins." [PMID:9491895] +synonym: "adiposome transport along microtubule" EXACT [] +synonym: "lipid body transport along microtubule" EXACT [] +synonym: "lipid particle transport along microtubule" EXACT [] +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0031889 +name: urotensin receptor binding +namespace: molecular_function +def: "Binding to a urotensin receptor." [GOC:mah, GOC:nln] +synonym: "urotensin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031890 +name: vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Binding to a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "VIP receptor binding" EXACT [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0031891 +name: type 1 vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Binding to a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "type 2 PACAP receptor binding" EXACT [] +is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding + +[Term] +id: GO:0031892 +name: type 2 vasoactive intestinal polypeptide receptor binding +namespace: molecular_function +def: "Binding to a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] +synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] +synonym: "type 3 PACAP receptor binding" EXACT [] +is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding + +[Term] +id: GO:0031893 +name: vasopressin receptor binding +namespace: molecular_function +def: "Binding to a vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "vasopressin receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0031894 +name: V1A vasopressin receptor binding +namespace: molecular_function +def: "Binding to a V1A vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V1A vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031895 +name: V1B vasopressin receptor binding +namespace: molecular_function +def: "Binding to a V1B vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V1B vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031896 +name: V2 vasopressin receptor binding +namespace: molecular_function +def: "Binding to a V2 vasopressin receptor." [GOC:mah, GOC:nln] +synonym: "V2 vasopressin receptor ligand" NARROW [] +is_a: GO:0031893 ! vasopressin receptor binding + +[Term] +id: GO:0031897 +name: Tic complex +namespace: cellular_component +def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] +synonym: "chloroplast inner membrane translocase complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009706 ! chloroplast inner membrane + +[Term] +id: GO:0031898 +name: chromoplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009509 ! chromoplast + +[Term] +id: GO:0031899 +name: chromoplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0046862 ! chromoplast membrane + +[Term] +id: GO:0031900 +name: chromoplast outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] +is_a: GO:0009527 ! plastid outer membrane +is_a: GO:0046862 ! chromoplast membrane + +[Term] +id: GO:0031901 +name: early endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an early endosome." [GOC:pz] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0005769 ! early endosome + +[Term] +id: GO:0031902 +name: late endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a late endosome." [GOC:pz] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0005770 ! late endosome + +[Term] +id: GO:0031903 +name: microbody membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a microbody." [GOC:mah] +is_a: GO:0042579 ! microbody +is_a: GO:0098588 ! bounding membrane of organelle + +[Term] +id: GO:0031904 +name: endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an endosome." [GOC:mah] +xref: NIF_Subcellular:sao1547508851 +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0031905 +name: early endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an early endosome." [GOC:mah] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0005769 ! early endosome + +[Term] +id: GO:0031906 +name: late endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a late endosome." [GOC:mah] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0005770 ! late endosome + +[Term] +id: GO:0031907 +name: microbody lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a microbody." [GOC:mah] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0042579 ! microbody + +[Term] +id: GO:0031908 +name: glyoxysomal lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] +is_a: GO:0005782 ! peroxisomal matrix + +[Term] +id: GO:0031910 +name: cytostome +namespace: cellular_component +def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] +xref: Wikipedia:Cytostome +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0031911 +name: cytoproct +namespace: cellular_component +def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189, PMID:23317460, PMID:27889663] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0031912 +name: oral apparatus +namespace: cellular_component +def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] +comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0031913 +name: contractile vacuole pore +namespace: cellular_component +def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0031164 ! contractile vacuolar membrane + +[Term] +id: GO:0031914 +name: negative regulation of synaptic plasticity +namespace: biological_process +def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] +synonym: "down regulation of synaptic plasticity" EXACT [] +synonym: "down-regulation of synaptic plasticity" EXACT [] +synonym: "downregulation of synaptic plasticity" EXACT [] +synonym: "inhibition of synaptic plasticity" NARROW [] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031915 +name: positive regulation of synaptic plasticity +namespace: biological_process +def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] +synonym: "activation of synaptic plasticity" NARROW [] +synonym: "stimulation of synaptic plasticity" NARROW [] +synonym: "up regulation of synaptic plasticity" EXACT [] +synonym: "up-regulation of synaptic plasticity" EXACT [] +synonym: "upregulation of synaptic plasticity" EXACT [] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031916 +name: regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0031917 +name: negative regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +synonym: "down regulation of synaptic metaplasticity" EXACT [] +synonym: "down-regulation of synaptic metaplasticity" EXACT [] +synonym: "downregulation of synaptic metaplasticity" EXACT [] +synonym: "inhibition of synaptic metaplasticity" NARROW [] +is_a: GO:0031914 ! negative regulation of synaptic plasticity +is_a: GO:0031916 ! regulation of synaptic metaplasticity + +[Term] +id: GO:0031918 +name: positive regulation of synaptic metaplasticity +namespace: biological_process +def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] +synonym: "activation of synaptic metaplasticity" NARROW [] +synonym: "stimulation of synaptic metaplasticity" NARROW [] +synonym: "up regulation of synaptic metaplasticity" EXACT [] +synonym: "up-regulation of synaptic metaplasticity" EXACT [] +synonym: "upregulation of synaptic metaplasticity" EXACT [] +is_a: GO:0031915 ! positive regulation of synaptic plasticity +is_a: GO:0031916 ! regulation of synaptic metaplasticity + +[Term] +id: GO:0031919 +name: vitamin B6 transport +namespace: biological_process +def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0051180 ! vitamin transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0031920 +name: pyridoxal transport +namespace: biological_process +def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031921 +name: pyridoxal phosphate transport +namespace: biological_process +def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031922 +name: pyridoxamine transport +namespace: biological_process +def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031923 +name: pyridoxine transport +namespace: biological_process +def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0031919 ! vitamin B6 transport + +[Term] +id: GO:0031924 +name: vitamin B6 transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other." [GOC:mah] +synonym: "vitamin B6 transporter activity" RELATED [] +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0031925 +name: pyridoxal transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +synonym: "pyridoxal transporter activity" BROAD [] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0031926 +name: pyridoxal phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0031927 +name: pyridoxamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0031928 +name: pyridoxine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] +synonym: "pyridoxine transporter activity" BROAD [] +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0031929 +name: TOR signaling +namespace: biological_process +def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] +comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. +synonym: "target of rapamycin signaling pathway" EXACT [] +synonym: "target of rapamycin signalling pathway" EXACT [] +synonym: "TOR signal transduction" EXACT [GOC:signaling] +synonym: "TOR signaling cascade" RELATED [GOC:signaling] +synonym: "TOR signaling pathway" EXACT [] +synonym: "TOR signalling pathway" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0031930 +name: mitochondria-nucleus signaling pathway +namespace: biological_process +def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799] +synonym: "mitochondria-nucleus signal transduction" EXACT [GOC:signaling] +synonym: "mitochondrial signaling pathway" EXACT [] +synonym: "mitochondrial signalling pathway" EXACT [] +synonym: "retrograde response" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0031931 +name: TORC1 complex +namespace: cellular_component +def: "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787] +synonym: "dTOR/dRaptor complex" NARROW [PMID:17183368] +synonym: "dTORC1" NARROW [PMID:17183368] +synonym: "mTORC1" NARROW [PMID:18765678, PMID:21548787] +synonym: "nutrient sensitive complex" EXACT [] +synonym: "rapamycin and nutrient-sensitive TOR complex" EXACT [PMID:21548787] +synonym: "TOR complex 1" EXACT [] +synonym: "TORC 1 complex" EXACT [] +synonym: "TORC1" EXACT [PMID:21548787] +xref: Wikipedia:MTORC1 +is_a: GO:0038201 ! TOR complex + +[Term] +id: GO:0031932 +name: TORC2 complex +namespace: cellular_component +def: "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787] +synonym: "mTORC2" NARROW [PMID:20496258, PMID:21548787] +synonym: "rapamycin and nutrient-insensitive TOR complex" EXACT [PMID:21548787] +synonym: "TOR complex 2" EXACT [] +synonym: "TORC 2 complex" EXACT [] +synonym: "TORC2" EXACT [PMID:21548787] +xref: Wikipedia:MTORC1 +is_a: GO:0038201 ! TOR complex + +[Term] +id: GO:0031933 +name: obsolete telomeric heterochromatin +namespace: cellular_component +def: "OBSOLETE. Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] +comment: This term was obsoleted because there is no heterochromatin at the telomere and the term had been used inconsistently. +synonym: "telomeric chromatin" BROAD [GOC:pr] +is_obsolete: true + +[Term] +id: GO:0031934 +name: mating-type region heterochromatin +namespace: cellular_component +def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0031935 +name: obsolete regulation of chromatin silencing +namespace: biological_process +def: "OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] +comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways. +synonym: "regulation of heterochromatic silencing" RELATED [] +is_obsolete: true + +[Term] +id: GO:0031936 +name: obsolete negative regulation of chromatin silencing +namespace: biological_process +alt_id: GO:0006345 +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] +comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways. +synonym: "down regulation of chromatin silencing" EXACT [] +synonym: "down-regulation of chromatin silencing" EXACT [] +synonym: "downregulation of chromatin silencing" EXACT [] +synonym: "inhibition of chromatin silencing" NARROW [] +synonym: "loss of chromatin silencing" EXACT [] +synonym: "negative regulation of heterochromatic silencing" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031937 +name: obsolete positive regulation of chromatin silencing +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah] +comment: This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways. +synonym: "activation of chromatin silencing" NARROW [] +synonym: "positive regulation of heterochromatic silencing" EXACT [] +synonym: "stimulation of chromatin silencing" NARROW [] +synonym: "up regulation of chromatin silencing" EXACT [] +synonym: "up-regulation of chromatin silencing" EXACT [] +synonym: "upregulation of chromatin silencing" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031938 +name: obsolete regulation of chromatin silencing at telomere +namespace: biological_process +def: "OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "regulation of heterochromatic silencing at telomere" EXACT [] +is_obsolete: true +consider: GO:0031509 + +[Term] +id: GO:0031939 +name: obsolete negative regulation of chromatin silencing at telomere +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "down regulation of chromatin silencing at telomere" EXACT [] +synonym: "down-regulation of chromatin silencing at telomere" EXACT [] +synonym: "downregulation of chromatin silencing at telomere" EXACT [] +synonym: "inhibition of chromatin silencing at telomere" NARROW [] +synonym: "negative regulation of heterochromatic silencing at telomere" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031940 +name: obsolete positive regulation of chromatin silencing at telomere +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "activation of chromatin silencing at telomere" NARROW [] +synonym: "positive regulation of heterochromatic silencing at telomere" EXACT [] +synonym: "stimulation of chromatin silencing at telomere" NARROW [] +synonym: "up regulation of chromatin silencing at telomere" EXACT [] +synonym: "up-regulation of chromatin silencing at telomere" EXACT [] +synonym: "upregulation of chromatin silencing at telomere" EXACT [] +is_obsolete: true + +[Term] +id: GO:0031941 +name: filamentous actin +namespace: cellular_component +def: "A two-stranded helical polymer of the protein actin." [GOC:mah] +comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. +synonym: "F-actin" EXACT [] +xref: Wikipedia:Actin +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005884 ! actin filament + +[Term] +id: GO:0031942 +name: i-AAA complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0031943 +name: regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031944 +name: negative regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid metabolic process" EXACT [] +synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "downregulation of glucocorticoid metabolic process" EXACT [] +synonym: "inhibition of glucocorticoid metabolic process" NARROW [] +synonym: "negative regulation of glucocorticoid metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031945 +name: positive regulation of glucocorticoid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid metabolic process" NARROW [] +synonym: "positive regulation of glucocorticoid metabolism" EXACT [] +synonym: "stimulation of glucocorticoid metabolic process" NARROW [] +synonym: "up regulation of glucocorticoid metabolic process" EXACT [] +synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] +synonym: "upregulation of glucocorticoid metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process + +[Term] +id: GO:0031946 +name: regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process +relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031947 +name: negative regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] +is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process +relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031948 +name: positive regulation of glucocorticoid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid biosynthetic process" NARROW [] +synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] +synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] +synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] +is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process +relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process + +[Term] +id: GO:0031949 +name: regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0031943 ! regulation of glucocorticoid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031950 +name: negative regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +synonym: "down regulation of glucocorticoid catabolic process" EXACT [] +synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] +synonym: "downregulation of glucocorticoid catabolic process" EXACT [] +synonym: "inhibition of glucocorticoid catabolic process" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process +is_a: GO:0031949 ! regulation of glucocorticoid catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031951 +name: positive regulation of glucocorticoid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] +synonym: "activation of glucocorticoid catabolic process" NARROW [] +synonym: "stimulation of glucocorticoid catabolic process" NARROW [] +synonym: "up regulation of glucocorticoid catabolic process" EXACT [] +synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] +synonym: "upregulation of glucocorticoid catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process +is_a: GO:0031949 ! regulation of glucocorticoid catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process + +[Term] +id: GO:0031952 +name: regulation of protein autophosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0031953 +name: negative regulation of protein autophosphorylation +namespace: biological_process +def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +synonym: "down regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "downregulation of protein amino acid autophosphorylation" EXACT [] +synonym: "inhibition of protein amino acid autophosphorylation" NARROW [] +synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0031952 ! regulation of protein autophosphorylation +relationship: negatively_regulates GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0031954 +name: positive regulation of protein autophosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] +synonym: "activation of protein amino acid autophosphorylation" NARROW [] +synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] +synonym: "stimulation of protein amino acid autophosphorylation" NARROW [] +synonym: "up regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid autophosphorylation" EXACT [] +synonym: "upregulation of protein amino acid autophosphorylation" EXACT [] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0031952 ! regulation of protein autophosphorylation +relationship: positively_regulates GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0031955 +name: short-chain fatty acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6." [EC:6.2.1.3, GOC:mah] +synonym: "short-chain fatty acid activation" RELATED [] +synonym: "short-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] +synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT [] +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0031956 +name: medium-chain fatty acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12." [GOC:mah, RHEA:48340] +synonym: "medium-chain fatty acid activation" RELATED [] +synonym: "medium-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] +synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT [] +xref: EC:6.2.1.2 +xref: RHEA:48340 +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0031957 +name: very long-chain fatty acid-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [EC:6.2.1.3, GOC:mah] +synonym: "very-long-chain fatty acid activation" RELATED [] +synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] +synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT [] +xref: Reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA" +xref: Reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA" +xref: Reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA" +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0031958 +name: corticosteroid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] +synonym: "corticosteroid receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0031959 +name: mineralocorticoid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] +synonym: "mineralocorticoid receptor signalling pathway" EXACT [] +is_a: GO:0031958 ! corticosteroid receptor signaling pathway + +[Term] +id: GO:0031960 +name: response to corticosteroid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] +synonym: "response to corticosteroid stimulus" EXACT [GOC:dos] +is_a: GO:0048545 ! response to steroid hormone + +[Term] +id: GO:0031961 +name: cortisol receptor binding +namespace: molecular_function +def: "Binding to a cortisol receptor." [GOC:mah, PMID:12511169] +is_a: GO:0035259 ! glucocorticoid receptor binding + +[Term] +id: GO:0031962 +name: mineralocorticoid receptor binding +namespace: molecular_function +def: "Binding to a mineralocorticoid receptor." [GOC:mah, PMID:12511169] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0031963 +name: cortisol receptor activity +namespace: molecular_function +def: "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:mah, PMID:12511169] +comment: For cortisol receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. +is_a: GO:0004883 ! glucocorticoid receptor activity + +[Term] +id: GO:0031964 +name: beta-alanyl-histamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine." [GOC:rc, PMID:16299587] +synonym: "carcinine hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0031965 +name: nuclear membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] +xref: NIF_Subcellular:sao1687101204 +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0031966 +name: mitochondrial membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] +xref: NIF_Subcellular:sao1045389829 +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0005740 ! mitochondrial envelope + +[Term] +id: GO:0031967 +name: organelle envelope +namespace: cellular_component +def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] +subset: goslim_mouse +is_a: GO:0031975 ! envelope +relationship: part_of GO:0043227 ! membrane-bounded organelle +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0031968 +name: organelle outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] +is_a: GO:0019867 ! outer membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0031969 +name: chloroplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] +xref: Wikipedia:Chloroplast_membrane +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0009941 ! chloroplast envelope + +[Term] +id: GO:0031970 +name: organelle envelope lumen +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] +synonym: "organelle intermembrane space" EXACT [] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0031967 ! organelle envelope + +[Term] +id: GO:0031972 +name: chloroplast intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] +synonym: "chloroplast envelope lumen" EXACT [] +is_a: GO:0009529 ! plastid intermembrane space +relationship: part_of GO:0009941 ! chloroplast envelope + +[Term] +id: GO:0031973 +name: chromoplast intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] +synonym: "chromoplast envelope lumen" EXACT [] +is_a: GO:0009529 ! plastid intermembrane space +relationship: part_of GO:0031898 ! chromoplast envelope + +[Term] +id: GO:0031974 +name: membrane-enclosed lumen +namespace: cellular_component +def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0031975 +name: envelope +namespace: cellular_component +def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0031976 +name: plastid thylakoid +namespace: cellular_component +def: "Any thylakoid within a plastid." [GOC:pz] +is_a: GO:0009579 ! thylakoid +is_a: GO:0031984 ! organelle subcompartment +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0031977 +name: thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009579 ! thylakoid + +[Term] +id: GO:0031978 +name: plastid thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] +is_a: GO:0031977 ! thylakoid lumen +relationship: part_of GO:0031976 ! plastid thylakoid + +[Term] +id: GO:0031979 +name: plasma membrane-derived thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] +synonym: "plasma membrane thylakoid lumen" EXACT [] +is_a: GO:0031977 ! thylakoid lumen +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0030075 ! bacterial thylakoid + +[Term] +id: GO:0031981 +name: nuclear lumen +namespace: cellular_component +def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0031982 +name: vesicle +namespace: cellular_component +alt_id: GO:0031988 +def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] +subset: goslim_pir +synonym: "membrane-bounded vesicle" RELATED [] +synonym: "membrane-enclosed vesicle" RELATED [] +xref: NIF_Subcellular:sao221389602 +xref: Wikipedia:Vesicle_(biology) +is_a: GO:0043227 ! membrane-bounded organelle + +[Term] +id: GO:0031983 +name: vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] +xref: NIF_Subcellular:sao797538226 +is_a: GO:0043233 ! organelle lumen +relationship: part_of GO:0031982 ! vesicle + +[Term] +id: GO:0031984 +name: organelle subcompartment +namespace: cellular_component +def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] +comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. +synonym: "suborganelle compartment" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043227 ! membrane-bounded organelle +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0031985 +name: Golgi cisterna +namespace: cellular_component +def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] +synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532] +xref: NIF_Subcellular:sao561419532 +is_a: GO:0098791 ! Golgi apparatus subcompartment +relationship: part_of GO:0005795 ! Golgi stack + +[Term] +id: GO:0031986 +name: proteinoplast +namespace: cellular_component +def: "A leucoplast in which protein is stored." [GOC:pz] +xref: Wikipedia:Proteinoplast +is_a: GO:0009516 ! leucoplast + +[Term] +id: GO:0031987 +name: locomotion involved in locomotory behavior +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] +synonym: "locomotion during locomotory behaviour" EXACT [] +is_a: GO:0040011 ! locomotion +relationship: part_of GO:0007626 ! locomotory behavior + +[Term] +id: GO:0031989 +name: bombesin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "bombesin receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0031990 +name: mRNA export from nucleus in response to heat stress +namespace: biological_process +def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw] +synonym: "mRNA export from cell nucleus during heat stress" EXACT [] +synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006406 ! mRNA export from nucleus +is_a: GO:0034605 ! cellular response to heat + +[Term] +id: GO:0031991 +name: regulation of actomyosin contractile ring contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of actomyosin contractile ring constriction" EXACT [GOC:vw] +synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0000916 ! actomyosin contractile ring contraction + +[Term] +id: GO:0031992 +name: energy transducer activity +namespace: molecular_function +def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] +subset: goslim_pir +synonym: "light harvesting activity" RELATED [] +synonym: "photon capture" RELATED [] +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0031993 +name: light transducer activity +namespace: molecular_function +def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] +is_a: GO:0031992 ! energy transducer activity + +[Term] +id: GO:0031994 +name: insulin-like growth factor I binding +namespace: molecular_function +def: "Binding to insulin-like growth factor I." [GOC:mah] +subset: goslim_chembl +synonym: "IGF-I binding" EXACT [] +is_a: GO:0005520 ! insulin-like growth factor binding + +[Term] +id: GO:0031995 +name: insulin-like growth factor II binding +namespace: molecular_function +def: "Binding to insulin-like growth factor II." [GOC:mah] +subset: goslim_chembl +synonym: "IGF-II binding" EXACT [] +is_a: GO:0005520 ! insulin-like growth factor binding + +[Term] +id: GO:0031996 +name: thioesterase binding +namespace: molecular_function +def: "Binding to a thioesterase." [GOC:dl] +synonym: "thiolesterase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0031997 +name: N-terminal myristoylation domain binding +namespace: molecular_function +def: "Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] +is_a: GO:0047485 ! protein N-terminus binding + +[Term] +id: GO:0031998 +name: regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0031999 +name: negative regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] +synonym: "down regulation of fatty acid beta-oxidation" EXACT [] +synonym: "down-regulation of fatty acid beta-oxidation" EXACT [] +synonym: "downregulation of fatty acid beta-oxidation" EXACT [] +synonym: "inhibition of fatty acid beta-oxidation" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0031998 ! regulation of fatty acid beta-oxidation +is_a: GO:0046322 ! negative regulation of fatty acid oxidation +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0032000 +name: positive regulation of fatty acid beta-oxidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] +synonym: "activation of fatty acid beta-oxidation" NARROW [] +synonym: "stimulation of fatty acid beta-oxidation" NARROW [] +synonym: "up regulation of fatty acid beta-oxidation" EXACT [] +synonym: "up-regulation of fatty acid beta-oxidation" EXACT [] +synonym: "upregulation of fatty acid beta-oxidation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0031998 ! regulation of fatty acid beta-oxidation +is_a: GO:0046321 ! positive regulation of fatty acid oxidation +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0032001 +name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." [EC:2.4.1.24] +synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] +synonym: "D-glucosyltransferase" BROAD [] +synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] +synonym: "T-enzyme" NARROW [] +xref: EC:2.4.1.24 +xref: MetaCyc:2.4.1.24-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0032002 +name: interleukin-28 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1)." [GOC:rph] +synonym: "IL-28 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0032003 +name: interleukin-28 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-28 receptor." [GOC:rph] +synonym: "IL-28" NARROW [] +synonym: "interleukin-28 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0032005 +name: signal transduction involved in positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah] +is_a: GO:0007165 ! signal transduction +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0032006 +name: regulation of TOR signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] +synonym: "regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "regulation of TOR signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of TOR signaling pathway" EXACT [] +synonym: "regulation of TOR signalling pathway" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0031929 ! TOR signaling + +[Term] +id: GO:0032007 +name: negative regulation of TOR signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] +synonym: "down regulation of TOR signaling pathway" EXACT [] +synonym: "down-regulation of TOR signaling pathway" EXACT [] +synonym: "downregulation of TOR signaling pathway" EXACT [] +synonym: "inhibition of TOR signaling pathway" NARROW [] +synonym: "negative regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "negative regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "negative regulation of TOR signaling cascade" RELATED [GOC:signaling] +synonym: "negative regulation of TOR signaling pathway" EXACT [] +synonym: "negative regulation of TOR signalling pathway" EXACT [] +is_a: GO:0032006 ! regulation of TOR signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0031929 ! TOR signaling + +[Term] +id: GO:0032008 +name: positive regulation of TOR signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] +synonym: "activation of TOR signaling pathway" NARROW [] +synonym: "positive regulation of target of rapamycin signaling pathway" EXACT [] +synonym: "positive regulation of target of rapamycin signalling pathway" EXACT [] +synonym: "positive regulation of TOR signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of TOR signaling pathway" EXACT [] +synonym: "positive regulation of TOR signalling pathway" EXACT [] +synonym: "stimulation of TOR signaling pathway" NARROW [] +synonym: "up regulation of TOR signaling pathway" EXACT [] +synonym: "up-regulation of TOR signaling pathway" EXACT [] +synonym: "upregulation of TOR signaling pathway" EXACT [] +is_a: GO:0032006 ! regulation of TOR signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0031929 ! TOR signaling + +[Term] +id: GO:0032009 +name: early phagosome +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] +synonym: "early phagocytic vesicle" EXACT [] +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0032010 +name: phagolysosome +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753, PMID:14733906] +synonym: "late phagocytic vesicle" RELATED [] +synonym: "late phagosome" RELATED [] +xref: Wikipedia:Phagolysosome +is_a: GO:0005767 ! secondary lysosome +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0032011 +name: ARF protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032012 +name: regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032013 +name: negative regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +synonym: "down regulation of ARF protein signal transduction" EXACT [] +synonym: "down-regulation of ARF protein signal transduction" EXACT [] +synonym: "downregulation of ARF protein signal transduction" EXACT [] +synonym: "inhibition of ARF protein signal transduction" NARROW [] +is_a: GO:0032012 ! regulation of ARF protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032014 +name: positive regulation of ARF protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] +synonym: "activation of ARF protein signal transduction" NARROW [] +synonym: "stimulation of ARF protein signal transduction" NARROW [] +synonym: "up regulation of ARF protein signal transduction" EXACT [] +synonym: "up-regulation of ARF protein signal transduction" EXACT [] +synonym: "upregulation of ARF protein signal transduction" EXACT [] +is_a: GO:0032012 ! regulation of ARF protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0032011 ! ARF protein signal transduction + +[Term] +id: GO:0032015 +name: regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032016 +name: negative regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +synonym: "down regulation of Ran protein signal transduction" EXACT [] +synonym: "down-regulation of Ran protein signal transduction" EXACT [] +synonym: "downregulation of Ran protein signal transduction" EXACT [] +synonym: "inhibition of Ran protein signal transduction" NARROW [] +is_a: GO:0032015 ! regulation of Ran protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032017 +name: positive regulation of Ran protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] +synonym: "activation of Ran protein signal transduction" NARROW [] +synonym: "stimulation of Ran protein signal transduction" NARROW [] +synonym: "up regulation of Ran protein signal transduction" EXACT [] +synonym: "up-regulation of Ran protein signal transduction" EXACT [] +synonym: "upregulation of Ran protein signal transduction" EXACT [] +is_a: GO:0032015 ! regulation of Ran protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0032018 +name: 2-methylbutanol:NADP oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] +synonym: "2-methylbutanal reductase (NADP) activity" EXACT [] +synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT [] +is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity + +[Term] +id: GO:0032019 +name: mitochondrial cloud +namespace: cellular_component +def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] +synonym: "Balbiani body" EXACT [] +synonym: "mitochondrial aggregate" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032020 +name: ISG15-protein conjugation +namespace: biological_process +def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah] +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0032021 +name: NELF complex +namespace: cellular_component +def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] +synonym: "negative elongation factor complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032023 +name: trypsinogen activation +namespace: biological_process +def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah] +synonym: "cleavage of trypsinogen to trypsin" EXACT [] +is_a: GO:0031638 ! zymogen activation + +[Term] +id: GO:0032024 +name: positive regulation of insulin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] +synonym: "activation of insulin secretion" NARROW [] +synonym: "stimulation of insulin secretion" NARROW [] +synonym: "up regulation of insulin secretion" EXACT [] +synonym: "up-regulation of insulin secretion" EXACT [] +synonym: "upregulation of insulin secretion" EXACT [] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0050796 ! regulation of insulin secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0032025 +name: response to cobalt ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0032026 +name: response to magnesium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0032027 +name: myosin light chain binding +namespace: molecular_function +def: "Binding to a light chain of a myosin complex." [GOC:mah] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0032028 +name: myosin head/neck binding +namespace: molecular_function +def: "Binding to the head/neck region of a myosin heavy chain." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032029 +name: myosin tail binding +namespace: molecular_function +def: "Binding to the tail region of a myosin heavy chain." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032030 +name: myosin I light chain binding +namespace: molecular_function +def: "Binding to a light chain of a myosin I complex." [GOC:mah] +is_a: GO:0017024 ! myosin I binding +is_a: GO:0032027 ! myosin light chain binding + +[Term] +id: GO:0032031 +name: myosin I head/neck binding +namespace: molecular_function +def: "Binding to the head/neck region of a myosin I heavy chain." [GOC:mah] +is_a: GO:0032028 ! myosin head/neck binding +is_a: GO:0032037 ! myosin I heavy chain binding + +[Term] +id: GO:0032032 +name: myosin I tail binding +namespace: molecular_function +def: "Binding to the tail region of a myosin I heavy chain." [GOC:mah] +is_a: GO:0032029 ! myosin tail binding +is_a: GO:0032037 ! myosin I heavy chain binding + +[Term] +id: GO:0032033 +name: myosin II light chain binding +namespace: molecular_function +def: "Binding to a light chain of a myosin II complex." [GOC:mah] +is_a: GO:0032027 ! myosin light chain binding +is_a: GO:0045159 ! myosin II binding + +[Term] +id: GO:0032034 +name: myosin II head/neck binding +namespace: molecular_function +def: "Binding to the head/neck region of a myosin II heavy chain." [GOC:mah] +is_a: GO:0032028 ! myosin head/neck binding +is_a: GO:0032038 ! myosin II heavy chain binding + +[Term] +id: GO:0032035 +name: myosin II tail binding +namespace: molecular_function +def: "Binding to the tail region of a myosin II heavy chain." [GOC:mah] +is_a: GO:0032029 ! myosin tail binding +is_a: GO:0032038 ! myosin II heavy chain binding + +[Term] +id: GO:0032036 +name: myosin heavy chain binding +namespace: molecular_function +def: "Binding to a heavy chain of a myosin complex." [GOC:mah] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0032037 +name: myosin I heavy chain binding +namespace: molecular_function +def: "Binding to a heavy chain of a myosin I complex." [GOC:mah] +is_a: GO:0017024 ! myosin I binding +is_a: GO:0032036 ! myosin heavy chain binding + +[Term] +id: GO:0032038 +name: myosin II heavy chain binding +namespace: molecular_function +def: "Binding to a heavy chain of a myosin II complex." [GOC:mah] +is_a: GO:0032036 ! myosin heavy chain binding +is_a: GO:0045159 ! myosin II binding + +[Term] +id: GO:0032039 +name: integrator complex +namespace: cellular_component +def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032040 +name: small-subunit processome +namespace: cellular_component +def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] +synonym: "small subunit processome" EXACT [] +synonym: "SSU processome" EXACT [] +is_a: GO:0030684 ! preribosome + +[Term] +id: GO:0032041 +name: NAD-dependent histone deacetylase activity (H3-K14 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [PMID:28450737] +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity +is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific) + +[Term] +id: GO:0032042 +name: mitochondrial DNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] +synonym: "mitochondrial DNA metabolism" EXACT [] +synonym: "mtDNA metabolic process" EXACT [] +synonym: "mtDNA metabolism" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0000002 ! mitochondrial genome maintenance + +[Term] +id: GO:0032043 +name: mitochondrial DNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] +synonym: "mitochondrial DNA breakdown" EXACT [] +synonym: "mitochondrial DNA catabolism" EXACT [] +synonym: "mitochondrial DNA degradation" EXACT [] +synonym: "mtDNA breakdown" EXACT [] +synonym: "mtDNA catabolic process" EXACT [] +synonym: "mtDNA catabolism" EXACT [] +synonym: "mtDNA degradation" EXACT [] +is_a: GO:0006308 ! DNA catabolic process +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:0032044 +name: DSIF complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865] +synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] +synonym: "DRB sensitivity inducing factor complex" EXACT [] +synonym: "Spt4-Spt5 complex" EXACT [] +synonym: "Spt5-Spt4 complex" EXACT [GOC:vw] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032045 +name: guanyl-nucleotide exchange factor complex +namespace: cellular_component +def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0032046 +name: micropexophagy-specific membrane apparatus +namespace: cellular_component +def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] +synonym: "micropexophagic apparatus" EXACT [] +synonym: "MIPA" EXACT [] +is_a: GO:0031984 ! organelle subcompartment +relationship: part_of GO:0005773 ! vacuole + +[Term] +id: GO:0032047 +name: mitosome +namespace: cellular_component +def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria." [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280] +comment: In Giardia species, mitosomes are sometimes present between the two nuclei. +synonym: "crypton" EXACT [] +xref: Wikipedia:Mitosome +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032048 +name: cardiolipin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah] +synonym: "cardiolipin metabolism" EXACT [] +synonym: "diphosphatidylglycerol metabolic process" RELATED [] +synonym: "diphosphatidylglycerol metabolism" RELATED [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process + +[Term] +id: GO:0032049 +name: cardiolipin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [GOC:mah] +synonym: "diphosphatidylglycerol biosynthesis" RELATED [] +synonym: "diphosphatidylglycerol biosynthetic process" RELATED [] +xref: MetaCyc:PWY-5269 +is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process +is_a: GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:0032050 +name: clathrin heavy chain binding +namespace: molecular_function +def: "Binding to a clathrin heavy chain." [GOC:mah] +is_a: GO:0030276 ! clathrin binding + +[Term] +id: GO:0032051 +name: clathrin light chain binding +namespace: molecular_function +def: "Binding to a clathrin light chain." [GOC:mah] +is_a: GO:0030276 ! clathrin binding + +[Term] +id: GO:0032052 +name: bile acid binding +namespace: molecular_function +def: "Binding to a bile acid, a steroid carboxylic acids occurring in bile." [GOC:rph] +is_a: GO:0033293 ! monocarboxylic acid binding + +[Term] +id: GO:0032053 +name: ciliary basal body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124] +synonym: "microtubule basal body organisation" BROAD [GOC:mah] +synonym: "microtubule basal body organization" BROAD [] +synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0031023 ! microtubule organizing center organization +is_a: GO:0044782 ! cilium organization + +[Term] +id: GO:0032055 +name: negative regulation of translation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "down regulation of translation in response to stress" EXACT [] +synonym: "down-regulation of translation in response to stress" EXACT [] +synonym: "downregulation of translation in response to stress" EXACT [] +synonym: "inhibition of translation in response to stress" NARROW [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0032056 +name: positive regulation of translation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "activation of translation in response to stress" NARROW [] +synonym: "stimulation of translation in response to stress" NARROW [] +synonym: "up regulation of translation in response to stress" EXACT [] +synonym: "up-regulation of translation in response to stress" EXACT [] +synonym: "upregulation of translation in response to stress" EXACT [] +is_a: GO:0043555 ! regulation of translation in response to stress +is_a: GO:0045727 ! positive regulation of translation + +[Term] +id: GO:0032057 +name: negative regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "down regulation of translation initiation in response to stress" EXACT [] +synonym: "down-regulation of translation initiation in response to stress" EXACT [] +synonym: "downregulation of translation initiation in response to stress" EXACT [] +synonym: "inhibition of translation initiation in response to stress" NARROW [] +is_a: GO:0045947 ! negative regulation of translational initiation +relationship: part_of GO:0006950 ! response to stress + +[Term] +id: GO:0032058 +name: positive regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] +synonym: "activation of translation initiation in response to stress" NARROW [] +synonym: "stimulation of translation initiation in response to stress" NARROW [] +synonym: "up regulation of translation initiation in response to stress" EXACT [] +synonym: "up-regulation of translation initiation in response to stress" EXACT [] +synonym: "upregulation of translation initiation in response to stress" EXACT [] +is_a: GO:0045948 ! positive regulation of translational initiation +relationship: part_of GO:0006950 ! response to stress + +[Term] +id: GO:0032059 +name: bleb +namespace: cellular_component +def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] +subset: goslim_pir +synonym: "plasma membrane bleb" EXACT [GOC:pr] +xref: Wikipedia:Bleb_(cell_biology) +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0032060 +name: bleb assembly +namespace: biological_process +def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)] +synonym: "blebbing" BROAD [GOC:pr] +synonym: "cell blebbing" EXACT [] +synonym: "membrane blebbing" BROAD [GOC:pr] +synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] +synonym: "plasma membrane blebbing" EXACT [GOC:pr] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0032061 +name: negative regulation of translation in response to osmotic stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "down regulation of translation in response to osmotic stress" EXACT [] +synonym: "down-regulation of translation in response to osmotic stress" EXACT [] +synonym: "downregulation of translation in response to osmotic stress" EXACT [] +synonym: "inhibition of translation in response to osmotic stress" NARROW [] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0043557 ! regulation of translation in response to osmotic stress + +[Term] +id: GO:0032062 +name: positive regulation of translation in response to osmotic stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "activation of translation in response to osmotic stress" NARROW [] +synonym: "stimulation of translation in response to osmotic stress" NARROW [] +synonym: "up regulation of translation in response to osmotic stress" EXACT [] +synonym: "up-regulation of translation in response to osmotic stress" EXACT [] +synonym: "upregulation of translation in response to osmotic stress" EXACT [] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0043557 ! regulation of translation in response to osmotic stress + +[Term] +id: GO:0032063 +name: negative regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "down regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "downregulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "inhibition of translation initiation in response to osmotic stress" NARROW [] +is_a: GO:0032057 ! negative regulation of translational initiation in response to stress +is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress +is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress + +[Term] +id: GO:0032064 +name: positive regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "activation of translation initiation in response to osmotic stress" NARROW [] +synonym: "stimulation of translation initiation in response to osmotic stress" NARROW [] +synonym: "up regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT [] +synonym: "upregulation of translation initiation in response to osmotic stress" EXACT [] +is_a: GO:0032058 ! positive regulation of translational initiation in response to stress +is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress +is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress + +[Term] +id: GO:0032065 +name: maintenance of protein location in cell cortex +namespace: biological_process +def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] +synonym: "cortical protein anchoring" RELATED [] +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0032067 +name: type IV site-specific deoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] +synonym: "type IV restriction enzyme activity" EXACT [] +is_a: GO:0015666 ! restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032068 +name: type IV site-specific deoxyribonuclease complex +namespace: cellular_component +def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] +synonym: "type IV restriction enzyme complex" EXACT [] +is_a: GO:1905347 ! endodeoxyribonuclease complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032069 +name: regulation of nuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "nuclease regulator activity" RELATED [] +is_a: GO:0051336 ! regulation of hydrolase activity +is_a: GO:0060255 ! regulation of macromolecule metabolic process + +[Term] +id: GO:0032070 +name: regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "deoxyribonuclease regulator" RELATED [] +synonym: "DNase regulator" RELATED [] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0051052 ! regulation of DNA metabolic process + +[Term] +id: GO:0032071 +name: regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "endodeoxyribonuclease regulator" RELATED [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity + +[Term] +id: GO:0032072 +name: regulation of restriction endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity + +[Term] +id: GO:0032073 +name: negative regulation of restriction endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] +synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW [] +synonym: "restriction alleviation" NARROW [] +synonym: "restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "restriction enzyme inhibitor" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity + +[Term] +id: GO:0032074 +name: negative regulation of nuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "down regulation of nuclease activity" EXACT [] +synonym: "down-regulation of nuclease activity" EXACT [] +synonym: "downregulation of nuclease activity" EXACT [] +synonym: "inhibition of nuclease activity" NARROW [] +synonym: "nuclease inhibitor" RELATED [] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0032075 +name: positive regulation of nuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] +synonym: "activation of nuclease activity" NARROW [] +synonym: "nuclease activator" RELATED [] +synonym: "stimulation of nuclease activity" NARROW [] +synonym: "up regulation of nuclease activity" EXACT [] +synonym: "up-regulation of nuclease activity" EXACT [] +synonym: "upregulation of nuclease activity" EXACT [] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0032076 +name: negative regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "deoxyribonuclease inhibitor" RELATED [] +synonym: "DNase inhibitor" RELATED [] +synonym: "down regulation of deoxyribonuclease activity" EXACT [] +synonym: "down-regulation of deoxyribonuclease activity" EXACT [] +synonym: "downregulation of deoxyribonuclease activity" EXACT [] +synonym: "inhibition of deoxyribonuclease activity" NARROW [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity +is_a: GO:0032074 ! negative regulation of nuclease activity +is_a: GO:0051053 ! negative regulation of DNA metabolic process + +[Term] +id: GO:0032077 +name: positive regulation of deoxyribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] +synonym: "activation of deoxyribonuclease activity" NARROW [] +synonym: "deoxyribonuclease activator" RELATED [] +synonym: "DNase activator" RELATED [] +synonym: "stimulation of deoxyribonuclease activity" NARROW [] +synonym: "up regulation of deoxyribonuclease activity" EXACT [] +synonym: "up-regulation of deoxyribonuclease activity" EXACT [] +synonym: "upregulation of deoxyribonuclease activity" EXACT [] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity +is_a: GO:0032075 ! positive regulation of nuclease activity +is_a: GO:0051054 ! positive regulation of DNA metabolic process + +[Term] +id: GO:0032078 +name: negative regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "down regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of endodeoxyribonuclease activity" EXACT [] +synonym: "endodeoxyribonuclease inhibitor" RELATED [] +synonym: "inhibition of endodeoxyribonuclease activity" NARROW [] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity +is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity + +[Term] +id: GO:0032079 +name: positive regulation of endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] +synonym: "activation of endodeoxyribonuclease activity" NARROW [] +synonym: "endodeoxyribonuclease activator" RELATED [] +synonym: "stimulation of endodeoxyribonuclease activity" NARROW [] +synonym: "up regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "up-regulation of endodeoxyribonuclease activity" EXACT [] +synonym: "upregulation of endodeoxyribonuclease activity" EXACT [] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity +is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity + +[Term] +id: GO:0032080 +name: negative regulation of type I site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of type I restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of type I restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "type I restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "type I restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032084 ! regulation of type I site-specific deoxyribonuclease activity +is_a: GO:0032780 ! negative regulation of ATP-dependent activity + +[Term] +id: GO:0032081 +name: negative regulation of type II site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of type II restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of type II restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "type II restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "type II restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032085 ! regulation of type II site-specific deoxyribonuclease activity + +[Term] +id: GO:0032082 +name: negative regulation of type III site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of type III restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of type III restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "type III restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "type III restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032086 ! regulation of type III site-specific deoxyribonuclease activity + +[Term] +id: GO:0032083 +name: negative regulation of type IV site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "down-regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "downregulation of type IV restriction endodeoxyribonuclease activity" EXACT [] +synonym: "inhibition of type IV restriction endodeoxyribonuclease activity" NARROW [] +synonym: "negative regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] +synonym: "type IV restriction endodeoxyribonuclease inhibitor" RELATED [] +synonym: "type IV restriction enzyme inhibitor" RELATED [] +is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity +is_a: GO:0032087 ! regulation of type IV site-specific deoxyribonuclease activity + +[Term] +id: GO:0032084 +name: regulation of type I site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "type I restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "type I restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity +is_a: GO:0043462 ! regulation of ATP-dependent activity + +[Term] +id: GO:0032085 +name: regulation of type II site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "type II restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "type II restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032086 +name: regulation of type III site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] +synonym: "regulation of type III restriction endoribonuclease activity" EXACT [GOC:dph] +synonym: "type III restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "type III restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032087 +name: regulation of type IV site-specific deoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity." [GOC:mah] +synonym: "regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph] +synonym: "type IV restriction endodeoxyribonuclease regulator" RELATED [] +synonym: "type IV restriction enzyme regulator" RELATED [] +is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity + +[Term] +id: GO:0032088 +name: negative regulation of NF-kappaB transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] +synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "NF-kappaB inhibitor" RELATED [] +is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0032089 +name: NACHT domain binding +namespace: molecular_function +def: "Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032090 +name: Pyrin domain binding +namespace: molecular_function +def: "Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] +synonym: "DAPIN domain binding" EXACT [] +synonym: "PAAD domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032091 +name: negative regulation of protein binding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] +synonym: "down regulation of protein binding" EXACT [] +synonym: "down-regulation of protein binding" EXACT [] +synonym: "downregulation of protein binding" EXACT [] +synonym: "inhibition of protein binding" NARROW [] +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0051100 ! negative regulation of binding + +[Term] +id: GO:0032092 +name: positive regulation of protein binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] +synonym: "activation of protein binding" NARROW [] +synonym: "stimulation of protein binding" NARROW [] +synonym: "up regulation of protein binding" EXACT [] +synonym: "up-regulation of protein binding" EXACT [] +synonym: "upregulation of protein binding" EXACT [] +is_a: GO:0043393 ! regulation of protein binding +is_a: GO:0051099 ! positive regulation of binding + +[Term] +id: GO:0032093 +name: SAM domain binding +namespace: molecular_function +def: "Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] +synonym: "Sterile Alpha Motif domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032094 +name: response to food +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0032095 +name: regulation of response to food +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0032094 ! response to food + +[Term] +id: GO:0032096 +name: negative regulation of response to food +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add] +synonym: "down regulation of response to food" EXACT [] +synonym: "down-regulation of response to food" EXACT [] +synonym: "downregulation of response to food" EXACT [] +synonym: "inhibition of response to food" NARROW [] +is_a: GO:0032095 ! regulation of response to food +is_a: GO:0032108 ! negative regulation of response to nutrient levels +relationship: negatively_regulates GO:0032094 ! response to food + +[Term] +id: GO:0032097 +name: positive regulation of response to food +namespace: biological_process +def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add] +synonym: "activation of response to food" NARROW [] +synonym: "stimulation of response to food" NARROW [] +synonym: "up regulation of response to food" EXACT [] +synonym: "up-regulation of response to food" EXACT [] +synonym: "upregulation of response to food" EXACT [] +is_a: GO:0032095 ! regulation of response to food +is_a: GO:0032109 ! positive regulation of response to nutrient levels +relationship: positively_regulates GO:0032094 ! response to food + +[Term] +id: GO:0032098 +name: regulation of appetite +namespace: biological_process +def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] +synonym: "regulation of hunger" RELATED [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032099 +name: negative regulation of appetite +namespace: biological_process +def: "Any process that reduces appetite." [GOC:add] +synonym: "appetite suppression" RELATED [] +synonym: "down regulation of appetite" EXACT [] +synonym: "down-regulation of appetite" EXACT [] +synonym: "downregulation of appetite" EXACT [] +synonym: "inhibition of appetite" NARROW [] +synonym: "negative regulation of hunger" RELATED [] +is_a: GO:0032096 ! negative regulation of response to food +is_a: GO:0032098 ! regulation of appetite + +[Term] +id: GO:0032100 +name: positive regulation of appetite +namespace: biological_process +def: "Any process that increases appetite." [GOC:add] +synonym: "activation of appetite" NARROW [] +synonym: "appetite stimulation" RELATED [] +synonym: "positive regulation of hunger" RELATED [] +synonym: "stimulation of appetite" NARROW [] +synonym: "up regulation of appetite" EXACT [] +synonym: "up-regulation of appetite" EXACT [] +synonym: "upregulation of appetite" EXACT [] +is_a: GO:0032097 ! positive regulation of response to food +is_a: GO:0032098 ! regulation of appetite + +[Term] +id: GO:0032101 +name: regulation of response to external stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032102 +name: negative regulation of response to external stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "down regulation of response to external stimulus" EXACT [] +synonym: "down-regulation of response to external stimulus" EXACT [] +synonym: "downregulation of response to external stimulus" EXACT [] +synonym: "inhibition of response to external stimulus" NARROW [] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032103 +name: positive regulation of response to external stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "activation of response to external stimulus" NARROW [] +synonym: "stimulation of response to external stimulus" NARROW [] +synonym: "up regulation of response to external stimulus" EXACT [] +synonym: "up-regulation of response to external stimulus" EXACT [] +synonym: "upregulation of response to external stimulus" EXACT [] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009605 ! response to external stimulus + +[Term] +id: GO:0032104 +name: regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032105 +name: negative regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] +synonym: "down regulation of response to extracellular stimulus" EXACT [] +synonym: "down-regulation of response to extracellular stimulus" EXACT [] +synonym: "downregulation of response to extracellular stimulus" EXACT [] +synonym: "inhibition of response to extracellular stimulus" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032106 +name: positive regulation of response to extracellular stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] +synonym: "activation of response to extracellular stimulus" NARROW [] +synonym: "stimulation of response to extracellular stimulus" NARROW [] +synonym: "up regulation of response to extracellular stimulus" EXACT [] +synonym: "up-regulation of response to extracellular stimulus" EXACT [] +synonym: "upregulation of response to extracellular stimulus" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: positively_regulates GO:0009991 ! response to extracellular stimulus + +[Term] +id: GO:0032107 +name: regulation of response to nutrient levels +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032108 +name: negative regulation of response to nutrient levels +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +synonym: "down regulation of response to nutrient levels" EXACT [] +synonym: "down-regulation of response to nutrient levels" EXACT [] +synonym: "downregulation of response to nutrient levels" EXACT [] +synonym: "inhibition of response to nutrient levels" NARROW [] +is_a: GO:0032105 ! negative regulation of response to extracellular stimulus +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: negatively_regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032109 +name: positive regulation of response to nutrient levels +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] +synonym: "activation of response to nutrient levels" NARROW [] +synonym: "stimulation of response to nutrient levels" NARROW [] +synonym: "up regulation of response to nutrient levels" EXACT [] +synonym: "up-regulation of response to nutrient levels" EXACT [] +synonym: "upregulation of response to nutrient levels" EXACT [] +is_a: GO:0032106 ! positive regulation of response to extracellular stimulus +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: positively_regulates GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0032110 +name: regulation of protein histidine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0032111 +name: activation of protein histidine kinase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah] +synonym: "protein histidine kinase activator" RELATED [] +is_a: GO:0010864 ! positive regulation of protein histidine kinase activity +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0032112 +name: negative regulation of protein histidine kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] +synonym: "down regulation of protein histidine kinase activity" EXACT [] +synonym: "down-regulation of protein histidine kinase activity" EXACT [] +synonym: "downregulation of protein histidine kinase activity" EXACT [] +synonym: "inhibition of protein histidine kinase activity" NARROW [] +synonym: "protein histidine kinase inhibitor" RELATED [] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0032110 ! regulation of protein histidine kinase activity + +[Term] +id: GO:0032113 +name: regulation of carbohydrate phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:0032114 +name: regulation of glucose-6-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp] +is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity + +[Term] +id: GO:0032115 +name: sorbose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14609] +synonym: "D-glucitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.289] +synonym: "Sou1p" RELATED [EC:1.1.1.289] +xref: EC:1.1.1.289 +xref: KEGG_REACTION:R07346 +xref: MetaCyc:1.1.1.289-RXN +xref: RHEA:14609 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032116 +name: SMC loading complex +namespace: cellular_component +def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] +synonym: "chromatin loading complex" RELATED [] +synonym: "cohesin loading complex" NARROW [] +synonym: "SCC2/SCC4 loading complex" NARROW [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032117 +name: horsetail-astral microtubule array +namespace: cellular_component +def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] +synonym: "HAA" EXACT [] +is_a: GO:0005818 ! aster +relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton + +[Term] +id: GO:0032118 +name: horsetail-astral microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah] +synonym: "horsetail-astral microtubule array organization" EXACT [] +synonym: "horsetail-astral microtubule organisation" EXACT [GOC:mah] +synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement + +[Term] +id: GO:0032119 +name: sequestering of zinc ion +namespace: biological_process +def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah] +is_a: GO:0051238 ! sequestering of metal ion +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0006882 ! cellular zinc ion homeostasis + +[Term] +id: GO:0032120 +name: ascospore-type prospore membrane formation +namespace: biological_process +alt_id: GO:0099097 +def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt, PMID:27630265] +synonym: "ascospore-type prospore membrane assembly" RELATED [] +synonym: "forespore membrane biosynthesis" EXACT [] +synonym: "forespore membrane formation" EXACT [] +synonym: "FSM assembly" EXACT [] +synonym: "FSM biosynthesis" EXACT [] +synonym: "FSM formation" EXACT [] +synonym: "prospore membrane biogenesis" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0071709 ! membrane assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0031321 ! ascospore-type prospore assembly + +[Term] +id: GO:0032121 +name: meiotic attachment of telomeric heterochromatin to spindle pole body +namespace: biological_process +def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890] +synonym: "attachment of telomeres to spindle pole body" BROAD [] +synonym: "attachment of telomeric chromatin to spindle pole body" BROAD [] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045141 ! meiotic telomere clustering + +[Term] +id: GO:0032122 +name: oral apparatus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830] +synonym: "oral apparatus morphogenesis" RELATED [] +synonym: "oral apparatus organisation" EXACT [GOC:mah] +synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah] +synonym: "stomatogenesis" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0032123 +name: deep fiber +namespace: cellular_component +def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] +synonym: "deep fibre" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0031912 ! oral apparatus + +[Term] +id: GO:0032124 +name: macronucleus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] +synonym: "macronuclear organization" EXACT [] +synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah] +synonym: "macronucleus organisation" EXACT [GOC:mah] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0032125 +name: micronucleus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] +synonym: "micronuclear organization" EXACT [] +synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah] +synonym: "micronucleus organisation" EXACT [GOC:mah] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0032126 +name: eisosome +namespace: cellular_component +def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779] +xref: Wikipedia:Eisosome +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0032127 +name: dense core granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] +synonym: "dense core vesicle membrane" EXACT [GOC:kmv] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0031045 ! dense core granule + +[Term] +id: GO:0032129 +name: histone deacetylase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [PMID:28450737] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0032130 +name: medial membrane band assembly +namespace: biological_process +def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003] +synonym: "medial membrane band formation" RELATED [GOC:dph] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:0032131 +name: alkylated DNA binding +namespace: molecular_function +def: "Binding to an alkylated residue in DNA." [GOC:mah] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:0032132 +name: O6-alkylguanine-DNA binding +namespace: molecular_function +def: "Binding to an O6-alkylguanine adduct in DNA." [GOC:mah, PMID:16679453] +is_a: GO:0032131 ! alkylated DNA binding + +[Term] +id: GO:0032133 +name: chromosome passenger complex +namespace: cellular_component +def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910] +synonym: "chromosomal passenger complex" EXACT [GOC:mcc] +synonym: "CPC" BROAD [GOC:mah] +synonym: "CPC complex" EXACT [GOC:vw] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0032135 +name: DNA insertion or deletion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing an insertion or a deletion." [GOC:vk] +synonym: "DNA insertion binding" NARROW [] +synonym: "insertion binding" EXACT [] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0032136 +name: adenine/cytosine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing an A/C mispair." [GOC:vk] +synonym: "A/C mispair binding" EXACT [GOC:bf] +synonym: "C/A mispair binding" EXACT [GOC:bf] +synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0032137 +name: guanine/thymine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a G/T mispair." [GOC:vk] +synonym: "G/T mispair binding" EXACT [GOC:bf] +synonym: "T/G mispair binding" EXACT [GOC:bf] +synonym: "thymine/guanine mispair binding" EXACT [GOC:bf] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0032138 +name: single base insertion or deletion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a single base insertion or deletion." [GOC:vk] +synonym: "single base insertion binding" NARROW [] +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0032139 +name: dinucleotide insertion or deletion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion." [GOC:vk] +synonym: "dinucleotide insertion binding" NARROW [] +is_a: GO:0032135 ! DNA insertion or deletion binding + +[Term] +id: GO:0032140 +name: single adenine insertion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032141 +name: single cytosine insertion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032142 +name: single guanine insertion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032143 +name: single thymine insertion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] +is_a: GO:0032138 ! single base insertion or deletion binding + +[Term] +id: GO:0032144 +name: 4-aminobutyrate transaminase complex +namespace: cellular_component +def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] +synonym: "ABAT complex" EXACT [] +synonym: "GABA transaminase complex" EXACT [] +synonym: "GABA-T complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0032145 +name: succinate-semialdehyde dehydrogenase binding +namespace: molecular_function +def: "Binding to succinate-semialdehyde dehydrogenase." [GOC:mah] +synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0032147 +name: activation of protein kinase activity +namespace: biological_process +def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] +synonym: "protein kinase activation" RELATED [] +is_a: GO:0045860 ! positive regulation of protein kinase activity + +[Term] +id: GO:0032148 +name: activation of protein kinase B activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg] +synonym: "protein kinase B activation" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0032149 +name: response to rhamnose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg] +synonym: "response to L-rhamnose stimulus" NARROW [] +synonym: "response to rhamnose stimulus" EXACT [GOC:dos] +is_a: GO:0009746 ! response to hexose + +[Term] +id: GO:0032150 +name: ubiquinone biosynthetic process from chorismate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0032151 +name: mitotic septin complex +namespace: cellular_component +def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] +is_a: GO:0031105 ! septin complex + +[Term] +id: GO:0032152 +name: meiotic septin complex +namespace: cellular_component +def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] +is_a: GO:0031105 ! septin complex + +[Term] +id: GO:0032153 +name: cell division site +namespace: cellular_component +def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] +comment: Note that this term refers to the future site of division in a cell that has not yet divided. +subset: goslim_pir +synonym: "cell division plane" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0032154 +name: cleavage furrow +namespace: cellular_component +def: "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] +comment: While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. +xref: Wikipedia:Cleavage_furrow +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0032155 +name: obsolete cell division site part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "cell division plane part" EXACT [] +is_obsolete: true +consider: GO:0032153 + +[Term] +id: GO:0032156 +name: septin cytoskeleton +namespace: cellular_component +def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032157 +name: prospore contractile ring +namespace: cellular_component +def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] +synonym: "actomyosin ring" RELATED [] +synonym: "cytokinetic ring" RELATED [] +synonym: "meiotic contractile ring" RELATED [] +is_a: GO:0110086 ! meiotic actomyosin contractile ring +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0032158 +name: septin band +namespace: cellular_component +def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0032159 +name: septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032156 ! septin cytoskeleton +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032160 +name: septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] +synonym: "septin bar" RELATED [] +is_a: GO:0032156 ! septin cytoskeleton +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032161 +name: cleavage apparatus septin structure +namespace: cellular_component +def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005938 ! cell cortex +relationship: part_of GO:0032153 ! cell division site +relationship: part_of GO:0032156 ! septin cytoskeleton + +[Term] +id: GO:0032162 +name: mating projection septin band +namespace: cellular_component +def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0032158 ! septin band +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0032163 +name: hyphal septin band +namespace: cellular_component +def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0032158 ! septin band + +[Term] +id: GO:0032164 +name: hyphal septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032159 ! septin cap + +[Term] +id: GO:0032165 +name: prospore septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] +is_a: GO:0032160 ! septin filament array + +[Term] +id: GO:0032166 +name: chlamydospore septin filament array +namespace: cellular_component +def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] +is_a: GO:0032160 ! septin filament array + +[Term] +id: GO:0032167 +name: obsolete septin patch +namespace: cellular_component +def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555] +comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure. +synonym: "septin patch" EXACT [] +is_obsolete: true + +[Term] +id: GO:0032168 +name: hyphal septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring + +[Term] +id: GO:0032169 +name: prospore septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring +is_a: GO:0032161 ! cleavage apparatus septin structure +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:0032170 +name: pseudohyphal septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring + +[Term] +id: GO:0032171 +name: germ tube septin cap +namespace: cellular_component +def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] +is_a: GO:0032159 ! septin cap +relationship: part_of GO:0032179 ! germ tube + +[Term] +id: GO:0032172 +name: germ tube septin ring +namespace: cellular_component +def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] +is_a: GO:0005940 ! septin ring +relationship: part_of GO:0032179 ! germ tube + +[Term] +id: GO:0032173 +name: septin collar +namespace: cellular_component +def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] +synonym: "septin hourglass" EXACT [PMID:32386534] +is_a: GO:0032156 ! septin cytoskeleton +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032174 +name: cellular bud neck septin collar +namespace: cellular_component +def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0032161 ! cleavage apparatus septin structure +is_a: GO:0032173 ! septin collar + +[Term] +id: GO:0032175 +name: mating projection septin ring +namespace: cellular_component +def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] +is_a: GO:0005940 ! septin ring +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0032176 +name: split septin rings +namespace: cellular_component +def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] +is_a: GO:0032156 ! septin cytoskeleton +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0032177 +name: cellular bud neck split septin rings +namespace: cellular_component +def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] +is_a: GO:0000399 ! cellular bud neck septin structure +is_a: GO:0032161 ! cleavage apparatus septin structure +is_a: GO:0032176 ! split septin rings + +[Term] +id: GO:0032178 +name: medial membrane band +namespace: cellular_component +def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] +synonym: "sterol-rich membrane band" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:0032179 +name: germ tube +namespace: cellular_component +def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] +subset: goslim_pir +xref: Wikipedia:Germ_tube +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0032180 +name: ubiquinone biosynthetic process from tyrosine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032181 +name: dinucleotide repeat insertion binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] +is_a: GO:0032139 ! dinucleotide insertion or deletion binding + +[Term] +id: GO:0032182 +name: ubiquitin-like protein binding +namespace: molecular_function +def: "Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] +subset: goslim_chembl +subset: goslim_yeast +synonym: "small conjugating protein binding" EXACT [GOC:dph] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032183 +name: SUMO binding +namespace: molecular_function +def: "Binding to the small ubiquitin-like protein SUMO." [GOC:mah] +synonym: "Smt3 binding" RELATED [] +synonym: "Smt3 monomer binding" NARROW [] +is_a: GO:0032182 ! ubiquitin-like protein binding + +[Term] +id: GO:0032184 +name: SUMO polymer binding +namespace: molecular_function +def: "Binding to a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] +synonym: "Smt3 polymer binding" EXACT [] +is_a: GO:0032183 ! SUMO binding + +[Term] +id: GO:0032185 +name: septin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] +synonym: "septin cytoskeleton organisation" EXACT [GOC:mah] +synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0032186 +name: cellular bud neck septin ring organization +namespace: biological_process +def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] +synonym: "cellular bud neck septin ring organisation" EXACT [GOC:mah] +is_a: GO:0031106 ! septin ring organization +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000281 ! mitotic cytokinesis +relationship: part_of GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:0032187 +name: actomyosin contractile ring localization +namespace: biological_process +def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] +synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] +synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +is_a: GO:0036214 ! contractile ring localization + +[Term] +id: GO:0032188 +name: establishment of actomyosin contractile ring localization +namespace: biological_process +def: "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah] +synonym: "actomyosin ring positioning" RELATED [GOC:mah] +synonym: "contractile ring positioning" BROAD [GOC:mah] +synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw] +synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] +synonym: "establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032187 ! actomyosin contractile ring localization +relationship: part_of GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:0032189 +name: maintenance of actomyosin contractile ring localization +namespace: biological_process +def: "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] +synonym: "cytokinetic ring anchoring" RELATED [] +synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] +synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032187 ! actomyosin contractile ring localization +relationship: part_of GO:0031566 ! actomyosin contractile ring maintenance + +[Term] +id: GO:0032190 +name: acrosin binding +namespace: molecular_function +alt_id: GO:0032191 +alt_id: GO:0032192 +def: "Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] +synonym: "acrosin heavy chain binding" NARROW [] +synonym: "acrosin light chain binding" NARROW [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0032193 +name: ubiquinone biosynthetic process via 2-polyprenylphenol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032194 +name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838] +is_a: GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:0032195 +name: post-lysosomal vacuole +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:23494323, PMID:9276759, PMID:9394012] +synonym: "post-lysosome" EXACT [GOC:dph] +synonym: "postlysosome" EXACT [] +is_a: GO:0005773 ! vacuole +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0032196 +name: transposition +namespace: biological_process +def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_pir +subset: goslim_yeast +xref: Wikipedia:Transposon +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0032197 +name: transposition, RNA-mediated +namespace: biological_process +alt_id: GO:0006319 +alt_id: GO:0006320 +alt_id: GO:0006321 +alt_id: GO:0006322 +def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090] +synonym: "Class I transposition" EXACT [] +synonym: "retrotransposition" EXACT [] +synonym: "retrotransposon transposition" EXACT [] +synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb] +synonym: "Tf transposition" NARROW [] +synonym: "Ty element transposition" NARROW [] +synonym: "Ty1 element transposition" NARROW [] +synonym: "Ty2 element transposition" NARROW [] +synonym: "Ty3 element transposition" NARROW [] +xref: Wikipedia:Transposon##Class_I\:_Retrotransposons +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0032198 +name: MITE transposition +namespace: biological_process +def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090] +synonym: "Class III transposition" EXACT [] +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0032199 +name: reverse transcription involved in RNA-mediated transposition +namespace: biological_process +def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090] +synonym: "reverse transcription during retrotransposition" EXACT [] +is_a: GO:0001171 ! reverse transcription +relationship: part_of GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0032200 +name: telomere organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "chromosome organization, telomeric" EXACT [] +synonym: "organization of chromosome, telomeric region" EXACT [] +synonym: "telomere organisation" EXACT [GOC:mah] +synonym: "telomere organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0032201 +name: telomere maintenance via semi-conservative replication +namespace: biological_process +def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication." [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261] +synonym: "equal telomere replication" RELATED [] +synonym: "telomeric fork progression" NARROW [] +synonym: "telomeric replication fork progression" NARROW [] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:0032202 +name: telomere assembly +namespace: biological_process +def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671] +synonym: "telomere formation" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0032200 ! telomere organization + +[Term] +id: GO:0032203 +name: telomere formation via telomerase +namespace: biological_process +def: "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme." [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671] +is_a: GO:0032202 ! telomere assembly + +[Term] +id: GO:0032204 +name: regulation of telomere maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032205 +name: negative regulation of telomere maintenance +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +synonym: "down regulation of telomere maintenance" EXACT [] +synonym: "down-regulation of telomere maintenance" EXACT [] +synonym: "downregulation of telomere maintenance" EXACT [] +synonym: "inhibition of telomere maintenance" NARROW [] +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032206 +name: positive regulation of telomere maintenance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] +synonym: "activation of telomere maintenance" NARROW [] +synonym: "stimulation of telomere maintenance" NARROW [] +synonym: "up regulation of telomere maintenance" EXACT [] +synonym: "up-regulation of telomere maintenance" EXACT [] +synonym: "upregulation of telomere maintenance" EXACT [] +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0000723 ! telomere maintenance + +[Term] +id: GO:0032207 +name: regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0072695 ! regulation of DNA recombination at telomere +relationship: regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032208 +name: negative regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +synonym: "down regulation of telomere maintenance via recombination" EXACT [] +synonym: "down-regulation of telomere maintenance via recombination" EXACT [] +synonym: "downregulation of telomere maintenance via recombination" EXACT [] +synonym: "inhibition of telomere maintenance via recombination" NARROW [] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:0032207 ! regulation of telomere maintenance via recombination +is_a: GO:0045950 ! negative regulation of mitotic recombination +is_a: GO:0048239 ! negative regulation of DNA recombination at telomere +relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032209 +name: positive regulation of telomere maintenance via recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] +synonym: "activation of telomere maintenance via recombination" NARROW [] +synonym: "stimulation of telomere maintenance via recombination" NARROW [] +synonym: "up regulation of telomere maintenance via recombination" EXACT [] +synonym: "up-regulation of telomere maintenance via recombination" EXACT [] +synonym: "upregulation of telomere maintenance via recombination" EXACT [] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0032207 ! regulation of telomere maintenance via recombination +is_a: GO:0045951 ! positive regulation of mitotic recombination +is_a: GO:0072696 ! positive regulation of DNA recombination at telomere +relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0032210 +name: regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032211 +name: negative regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +synonym: "down regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "downregulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "inhibition of telomere maintenance via telomerase" NARROW [] +is_a: GO:0032210 ! regulation of telomere maintenance via telomerase +is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process +relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032212 +name: positive regulation of telomere maintenance via telomerase +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] +synonym: "activation of telomere maintenance via telomerase" NARROW [] +synonym: "stimulation of telomere maintenance via telomerase" NARROW [] +synonym: "up regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT [] +synonym: "upregulation of telomere maintenance via telomerase activity" EXACT [] +is_a: GO:0032210 ! regulation of telomere maintenance via telomerase +is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process +relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase + +[Term] +id: GO:0032213 +name: regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032214 +name: negative regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication +relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032215 +name: positive regulation of telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] +synonym: "activation of telomere maintenance via semi-conservative replication" NARROW [] +synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW [] +synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT [] +synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT [] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication + +[Term] +id: GO:0032216 +name: glucosaminyl-phosphatidylinositol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA." [Reactome:R-HSA-162683] +synonym: "glucosaminyl-phosphotidylinositol O-acyltransferase activity" EXACT [] +synonym: "GPI-inositol acyltransferase" RELATED [] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0032217 +name: riboflavin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] +synonym: "riboflavin transporter activity" RELATED [] +xref: Reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol" +xref: RHEA:35015 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0032218 +name: riboflavin transport +namespace: biological_process +def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0051180 ! vitamin transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0032219 +name: cell wall macromolecule catabolic process involved in cytogamy +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah] +synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb] +is_a: GO:0016998 ! cell wall macromolecule catabolic process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0000755 ! cytogamy + +[Term] +id: GO:0032220 +name: plasma membrane fusion involved in cytogamy +namespace: biological_process +alt_id: GO:0070872 +def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah, PMID:29134248] +synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb] +synonym: "plasma membrane organization involved in conjugation with cellular fusion" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0000755 ! cytogamy + +[Term] +id: GO:0032221 +name: Rpd3S/Clr6-CII complex +namespace: cellular_component +alt_id: GO:0000509 +def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] +synonym: "Clr6 histone deacetylase complex II" EXACT [] +synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw] +synonym: "Clr6-CII" EXACT [] +synonym: "Clr6S complex" EXACT [PMID:19040720] +synonym: "Rpd3C(S)" EXACT [] +synonym: "Rpd3S complex" EXACT [] +is_a: GO:0070822 ! Sin3-type complex + +[Term] +id: GO:0032222 +name: regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032223 +name: negative regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] +synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032224 +name: positive regulation of synaptic transmission, cholinergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] +synonym: "activation of synaptic transmission, cholinergic" NARROW [] +synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] +synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] +synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic + +[Term] +id: GO:0032225 +name: regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032226 +name: positive regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +synonym: "activation of synaptic transmission, dopaminergic" NARROW [] +synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] +synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] +is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032227 +name: negative regulation of synaptic transmission, dopaminergic +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] +synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] +synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] +is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0032228 +name: regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032229 +name: negative regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] +synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050805 ! negative regulation of synaptic transmission +relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032230 +name: positive regulation of synaptic transmission, GABAergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] +synonym: "activation of synaptic transmission, GABAergic" NARROW [] +synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] +synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] +synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] +is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0032231 +name: regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0110053 ! regulation of actin filament organization +relationship: regulates GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0032232 +name: negative regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "down regulation of actin filament bundle formation" EXACT [] +synonym: "down-regulation of actin filament bundle formation" EXACT [] +synonym: "downregulation of actin filament bundle formation" EXACT [] +synonym: "inhibition of actin filament bundle formation" NARROW [] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0032233 +name: positive regulation of actin filament bundle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] +synonym: "activation of actin filament bundle formation" NARROW [] +synonym: "stimulation of actin filament bundle formation" NARROW [] +synonym: "up regulation of actin filament bundle formation" EXACT [] +synonym: "up-regulation of actin filament bundle formation" EXACT [] +synonym: "upregulation of actin filament bundle formation" EXACT [] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0051017 ! actin filament bundle assembly + +[Term] +id: GO:0032234 +name: obsolete regulation of calcium ion transport via store-operated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] +synonym: "regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "regulation of store-operated calcium channel activity" EXACT [] +is_obsolete: true +consider: GO:0015279 + +[Term] +id: GO:0032235 +name: obsolete negative regulation of calcium ion transport via store-operated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "negative regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] +synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "negative regulation of store-operated calcium channel activity" EXACT [] +is_obsolete: true +consider: GO:0015279 + +[Term] +id: GO:0032236 +name: obsolete positive regulation of calcium ion transport via store-operated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "positive regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] +synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT [] +synonym: "positive regulation of store-operated calcium channel activity" EXACT [] +synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW [] +synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT [] +synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT [] +is_obsolete: true +consider: GO:0015279 + +[Term] +id: GO:0032237 +name: activation of store-operated calcium channel activity +namespace: biological_process +def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah] +is_a: GO:1901341 ! positive regulation of store-operated calcium channel activity + +[Term] +id: GO:0032238 +name: adenosine transport +namespace: biological_process +def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032239 +name: regulation of nucleobase-containing compound transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015931 ! nucleobase-containing compound transport + +[Term] +id: GO:0032240 +name: negative regulation of nucleobase-containing compound transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport + +[Term] +id: GO:0032241 +name: positive regulation of nucleobase-containing compound transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] +synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] +synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport + +[Term] +id: GO:0032242 +name: regulation of nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +relationship: regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032243 +name: negative regulation of nucleoside transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of nucleoside transport" EXACT [] +synonym: "down-regulation of nucleoside transport" EXACT [] +synonym: "downregulation of nucleoside transport" EXACT [] +synonym: "inhibition of nucleoside transport" NARROW [] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: negatively_regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032244 +name: positive regulation of nucleoside transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of nucleoside transport" NARROW [] +synonym: "stimulation of nucleoside transport" NARROW [] +synonym: "up regulation of nucleoside transport" EXACT [] +synonym: "up-regulation of nucleoside transport" EXACT [] +synonym: "upregulation of nucleoside transport" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: positively_regulates GO:0015858 ! nucleoside transport + +[Term] +id: GO:0032245 +name: regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032242 ! regulation of nucleoside transport + +[Term] +id: GO:0032246 +name: regulation of pyrimidine nucleoside transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032242 ! regulation of nucleoside transport +relationship: regulates GO:0015864 ! pyrimidine nucleoside transport + +[Term] +id: GO:0032247 +name: negative regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of purine nucleoside transport" EXACT [] +synonym: "down-regulation of purine nucleoside transport" EXACT [] +synonym: "downregulation of purine nucleoside transport" EXACT [] +synonym: "inhibition of purine nucleoside transport" NARROW [] +is_a: GO:0032243 ! negative regulation of nucleoside transport +is_a: GO:0032245 ! regulation of purine nucleoside transport + +[Term] +id: GO:0032248 +name: positive regulation of purine nucleoside transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of purine nucleoside transport" NARROW [] +synonym: "stimulation of purine nucleoside transport" NARROW [] +synonym: "up regulation of purine nucleoside transport" EXACT [] +synonym: "up-regulation of purine nucleoside transport" EXACT [] +synonym: "upregulation of purine nucleoside transport" EXACT [] +is_a: GO:0032244 ! positive regulation of nucleoside transport +is_a: GO:0032245 ! regulation of purine nucleoside transport + +[Term] +id: GO:0032249 +name: regulation of adenosine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032245 ! regulation of purine nucleoside transport +relationship: regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032250 +name: negative regulation of adenosine transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of adenosine transport" EXACT [] +synonym: "down-regulation of adenosine transport" EXACT [] +synonym: "downregulation of adenosine transport" EXACT [] +synonym: "inhibition of adenosine transport" NARROW [] +is_a: GO:0032247 ! negative regulation of purine nucleoside transport +is_a: GO:0032249 ! regulation of adenosine transport +relationship: negatively_regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032251 +name: positive regulation of adenosine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of adenosine transport" NARROW [] +synonym: "stimulation of adenosine transport" NARROW [] +synonym: "up regulation of adenosine transport" EXACT [] +synonym: "up-regulation of adenosine transport" EXACT [] +synonym: "upregulation of adenosine transport" EXACT [] +is_a: GO:0032248 ! positive regulation of purine nucleoside transport +is_a: GO:0032249 ! regulation of adenosine transport +relationship: positively_regulates GO:0032238 ! adenosine transport + +[Term] +id: GO:0032252 +name: secretory granule localization +namespace: biological_process +def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] +synonym: "secretory granule clustering" RELATED [] +synonym: "secretory granule localisation" EXACT [GOC:mah] +is_a: GO:0051648 ! vesicle localization + +[Term] +id: GO:0032253 +name: dense core granule localization +namespace: biological_process +def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] +synonym: "dense core granule clustering" RELATED [] +synonym: "dense core granule localisation" EXACT [GOC:mah] +synonym: "dense core vesicle localization" EXACT [GOC:kmv] +is_a: GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032254 +name: establishment of secretory granule localization +namespace: biological_process +def: "The directed movement of a secretory granule to a specific location." [GOC:mah] +synonym: "establishment of secretory granule localisation" EXACT [GOC:mah] +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032255 +name: maintenance of secretory granule location +namespace: biological_process +def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051655 ! maintenance of vesicle location +relationship: part_of GO:0032252 ! secretory granule localization + +[Term] +id: GO:0032256 +name: establishment of dense core granule localization +namespace: biological_process +def: "The directed movement of a dense core granule to a specific location." [GOC:mah] +synonym: "establishment of dense core granule localisation" EXACT [GOC:mah] +synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv] +is_a: GO:0032254 ! establishment of secretory granule localization +relationship: part_of GO:0032253 ! dense core granule localization + +[Term] +id: GO:0032257 +name: maintenance of dense core granule location +namespace: biological_process +def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv] +is_a: GO:0032255 ! maintenance of secretory granule location +relationship: part_of GO:0032253 ! dense core granule localization + +[Term] +id: GO:0032258 +name: cytoplasm to vacuole transport by the Cvt pathway +namespace: biological_process +def: "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] +synonym: "cytoplasm to vacuole targeting" BROAD [] +synonym: "cytoplasm-to-vacuole targeting" BROAD [] +synonym: "protein localization by the Cvt pathway" EXACT [] +is_a: GO:0006623 ! protein targeting to vacuole +is_a: GO:0061919 ! process utilizing autophagic mechanism + +[Term] +id: GO:0032259 +name: methylation +namespace: biological_process +def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] +subset: goslim_chembl +xref: Wikipedia:Methylation +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0032260 +name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah] +synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] +is_a: GO:0009753 ! response to jasmonic acid +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0032261 +name: purine nucleotide salvage +namespace: biological_process +def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0043101 ! purine-containing compound salvage +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0032262 +name: pyrimidine nucleotide salvage +namespace: biological_process +def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process +is_a: GO:0008655 ! pyrimidine-containing compound salvage +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0032263 +name: GMP salvage +namespace: biological_process +def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0006177 ! GMP biosynthetic process +is_a: GO:0106380 ! purine ribonucleotide salvage + +[Term] +id: GO:0032264 +name: IMP salvage +namespace: biological_process +def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0006188 ! IMP biosynthetic process +is_a: GO:0106380 ! purine ribonucleotide salvage + +[Term] +id: GO:0032265 +name: XMP salvage +namespace: biological_process +def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] +is_a: GO:0097293 ! XMP biosynthetic process +is_a: GO:0106380 ! purine ribonucleotide salvage + +[Term] +id: GO:0032266 +name: phosphatidylinositol-3-phosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] +synonym: "phosphatidylinositol 3-phosphate binding" EXACT [] +synonym: "PtdIns-3-P binding" EXACT [] +is_a: GO:1901981 ! phosphatidylinositol phosphate binding + +[Term] +id: GO:0032267 +name: tRNA(Ile)-lysidine synthase activity +namespace: molecular_function +def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] +synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] +synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] +xref: EC:6.3.4.- +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0032268 +name: regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +synonym: "regulation of cellular protein metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032269 +name: negative regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +synonym: "down regulation of cellular protein metabolic process" EXACT [] +synonym: "down-regulation of cellular protein metabolic process" EXACT [] +synonym: "downregulation of cellular protein metabolic process" EXACT [] +synonym: "inhibition of cellular protein metabolic process" NARROW [] +synonym: "negative regulation of cellular protein metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032270 +name: positive regulation of cellular protein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] +synonym: "activation of cellular protein metabolic process" NARROW [] +synonym: "positive regulation of cellular protein metabolism" EXACT [] +synonym: "stimulation of cellular protein metabolic process" NARROW [] +synonym: "up regulation of cellular protein metabolic process" EXACT [] +synonym: "up-regulation of cellular protein metabolic process" EXACT [] +synonym: "upregulation of cellular protein metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0032271 +name: regulation of protein polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "regulation of protein polymerisation" EXACT [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032272 +name: negative regulation of protein polymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "down regulation of protein polymerization" EXACT [] +synonym: "down-regulation of protein polymerization" EXACT [] +synonym: "downregulation of protein polymerization" EXACT [] +synonym: "inhibition of protein polymerization" NARROW [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0032271 ! regulation of protein polymerization +relationship: negatively_regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032273 +name: positive regulation of protein polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] +synonym: "activation of protein polymerization" NARROW [] +synonym: "stimulation of protein polymerization" NARROW [] +synonym: "up regulation of protein polymerization" EXACT [] +synonym: "up-regulation of protein polymerization" EXACT [] +synonym: "upregulation of protein polymerization" EXACT [] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0032271 ! regulation of protein polymerization +relationship: positively_regulates GO:0051258 ! protein polymerization + +[Term] +id: GO:0032274 +name: gonadotropin secretion +namespace: biological_process +def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544] +synonym: "gonadotrophin secretion" EXACT [] +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0032275 +name: luteinizing hormone secretion +namespace: biological_process +def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] +is_a: GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032276 +name: regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "regulation of gonadotrophin secretion" EXACT [] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032277 +name: negative regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "down regulation of gonadotropin secretion" EXACT [] +synonym: "down-regulation of gonadotropin secretion" EXACT [] +synonym: "downregulation of gonadotropin secretion" EXACT [] +synonym: "inhibition of gonadotropin secretion" NARROW [] +synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph] +is_a: GO:0032276 ! regulation of gonadotropin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032278 +name: positive regulation of gonadotropin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] +synonym: "activation of gonadotropin secretion" NARROW [] +synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph] +synonym: "stimulation of gonadotropin secretion" NARROW [] +synonym: "up regulation of gonadotropin secretion" EXACT [] +synonym: "up-regulation of gonadotropin secretion" EXACT [] +synonym: "upregulation of gonadotropin secretion" EXACT [] +is_a: GO:0032276 ! regulation of gonadotropin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0032279 +name: asymmetric synapse +namespace: cellular_component +def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] +synonym: "Gray's type I synapse" EXACT [] +is_a: GO:0098984 ! neuron to neuron synapse + +[Term] +id: GO:0032280 +name: symmetric synapse +namespace: cellular_component +def: "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory." [GOC:dgh, GOC:ef] +comment: The term 'symmetric' in this name refers only to gross morphology. There is no implication of functional symmetry. +synonym: "Gray's type II synapse" EXACT [] +is_a: GO:0098984 ! neuron to neuron synapse + +[Term] +id: GO:0032281 +name: AMPA glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] +synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex" EXACT [] +synonym: "AMPA receptor" RELATED [] +synonym: "AMPA-selective glutamate receptor complex" EXACT [] +is_a: GO:0008328 ! ionotropic glutamate receptor complex +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0032282 +name: plastid acetyl-CoA carboxylase complex +namespace: cellular_component +def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] +synonym: "plastid ACCase complex" EXACT [] +is_a: GO:0009317 ! acetyl-CoA carboxylase complex +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0032283 +name: plastid acetate CoA-transferase complex +namespace: cellular_component +def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] +is_a: GO:0009329 ! acetate CoA-transferase complex +relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex + +[Term] +id: GO:0032284 +name: plastid biotin carboxylase complex +namespace: cellular_component +def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] +is_a: GO:0009343 ! biotin carboxylase complex +relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex + +[Term] +id: GO:0032285 +name: non-myelinated axon ensheathment +namespace: biological_process +def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh] +synonym: "ensheathment of non-myelinated axons" EXACT [] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032286 +name: central nervous system myelin maintenance +namespace: biological_process +def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh] +synonym: "myelin maintenance in central nervous system" EXACT [] +is_a: GO:0043217 ! myelin maintenance +relationship: part_of GO:0022010 ! central nervous system myelination + +[Term] +id: GO:0032287 +name: peripheral nervous system myelin maintenance +namespace: biological_process +def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh] +synonym: "myelin maintenance in peripheral nervous system" EXACT [] +is_a: GO:0043217 ! myelin maintenance +relationship: part_of GO:0022011 ! myelination in peripheral nervous system + +[Term] +id: GO:0032288 +name: myelin assembly +namespace: biological_process +def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] +synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +relationship: part_of GO:0042552 ! myelination + +[Term] +id: GO:0032289 +name: central nervous system myelin formation +namespace: biological_process +def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] +synonym: "myelin formation in central nervous system" EXACT [] +is_a: GO:0032288 ! myelin assembly +relationship: part_of GO:0022010 ! central nervous system myelination + +[Term] +id: GO:0032290 +name: peripheral nervous system myelin formation +namespace: biological_process +def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system." [GOC:dgh] +synonym: "myelin formation in peripheral nervous system" EXACT [] +is_a: GO:0032288 ! myelin assembly +relationship: part_of GO:0022011 ! myelination in peripheral nervous system + +[Term] +id: GO:0032291 +name: axon ensheathment in central nervous system +namespace: biological_process +def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] +synonym: "ensheathment of axons in central nervous system" EXACT [] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032292 +name: peripheral nervous system axon ensheathment +namespace: biological_process +def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] +synonym: "ensheathment of axons in peripheral nervous system" EXACT [] +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0032293 +name: non-myelinated axon ensheathment in central nervous system +namespace: biological_process +def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh] +synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT [] +is_a: GO:0032285 ! non-myelinated axon ensheathment +is_a: GO:0032291 ! axon ensheathment in central nervous system + +[Term] +id: GO:0032294 +name: peripheral nervous system non-myelinated axon ensheathment +namespace: biological_process +def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh] +synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT [] +is_a: GO:0032285 ! non-myelinated axon ensheathment +is_a: GO:0032292 ! peripheral nervous system axon ensheathment + +[Term] +id: GO:0032295 +name: ensheathment of neuronal cell bodies +namespace: biological_process +def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh] +is_a: GO:0007272 ! ensheathment of neurons + +[Term] +id: GO:0032296 +name: double-stranded RNA-specific ribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] +synonym: "double-stranded RNA-specific RNase activity" EXACT [] +synonym: "dsRNA-specific ribonuclease activity" EXACT [] +synonym: "dsRNA-specific RNase activity" EXACT [] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0032297 +name: negative regulation of DNA-dependent DNA replication initiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] +synonym: "down regulation of DNA replication initiation" EXACT [] +synonym: "down-regulation of DNA replication initiation" EXACT [] +synonym: "downregulation of DNA replication initiation" EXACT [] +synonym: "inhibition of DNA replication initiation" NARROW [] +synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] +is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0032298 +name: positive regulation of DNA-dependent DNA replication initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] +synonym: "activation of DNA replication initiation" NARROW [] +synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] +synonym: "stimulation of DNA replication initiation" NARROW [] +synonym: "up regulation of DNA replication initiation" EXACT [] +synonym: "up-regulation of DNA replication initiation" EXACT [] +synonym: "upregulation of DNA replication initiation" EXACT [] +is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication +relationship: positively_regulates GO:0006270 ! DNA replication initiation + +[Term] +id: GO:0032299 +name: ribonuclease H2 complex +namespace: cellular_component +def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] +synonym: "RNase H2 complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0032300 +name: mismatch repair complex +namespace: cellular_component +def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] +subset: goslim_pir +is_a: GO:1990391 ! DNA repair complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0032301 +name: MutSalpha complex +namespace: cellular_component +def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] +synonym: "MMR complex" BROAD [] +synonym: "MSH2/MSH6 complex" EXACT [] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032302 +name: MutSbeta complex +namespace: cellular_component +def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] +synonym: "MMR complex" BROAD [] +synonym: "MSH2/MSH3 complex" EXACT [] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032303 +name: regulation of icosanoid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] +synonym: "regulation of eicosanoid secretion" EXACT [] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051046 ! regulation of secretion +is_a: GO:2000191 ! regulation of fatty acid transport +relationship: regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032304 +name: negative regulation of icosanoid secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] +synonym: "down regulation of icosanoid secretion" EXACT [] +synonym: "down-regulation of icosanoid secretion" EXACT [] +synonym: "downregulation of icosanoid secretion" EXACT [] +synonym: "inhibition of icosanoid secretion" NARROW [] +synonym: "negative regulation of eicosanoid secretion" EXACT [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:2000192 ! negative regulation of fatty acid transport +relationship: negatively_regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032305 +name: positive regulation of icosanoid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] +synonym: "activation of icosanoid secretion" NARROW [] +synonym: "positive regulation of eicosanoid secretion" EXACT [] +synonym: "stimulation of icosanoid secretion" NARROW [] +synonym: "up regulation of icosanoid secretion" EXACT [] +synonym: "up-regulation of icosanoid secretion" EXACT [] +synonym: "upregulation of icosanoid secretion" EXACT [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:2000193 ! positive regulation of fatty acid transport +relationship: positively_regulates GO:0032309 ! icosanoid secretion + +[Term] +id: GO:0032306 +name: regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] +synonym: "regulation of prostacyclin secretion" NARROW [] +is_a: GO:0032303 ! regulation of icosanoid secretion +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032307 +name: negative regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] +synonym: "down regulation of prostaglandin secretion" EXACT [] +synonym: "down-regulation of prostaglandin secretion" EXACT [] +synonym: "downregulation of prostaglandin secretion" EXACT [] +synonym: "inhibition of prostaglandin secretion" NARROW [] +synonym: "negative regulation of prostacyclin secretion" NARROW [] +is_a: GO:0032304 ! negative regulation of icosanoid secretion +is_a: GO:0032306 ! regulation of prostaglandin secretion +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032308 +name: positive regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] +synonym: "activation of prostaglandin secretion" NARROW [] +synonym: "positive regulation of prostacyclin secretion" NARROW [] +synonym: "stimulation of prostaglandin secretion" NARROW [] +synonym: "up regulation of prostaglandin secretion" EXACT [] +synonym: "up-regulation of prostaglandin secretion" EXACT [] +synonym: "upregulation of prostaglandin secretion" EXACT [] +is_a: GO:0032305 ! positive regulation of icosanoid secretion +is_a: GO:0032306 ! regulation of prostaglandin secretion +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0032310 ! prostaglandin secretion + +[Term] +id: GO:0032309 +name: icosanoid secretion +namespace: biological_process +def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah] +synonym: "eicosanoid secretion" EXACT [] +is_a: GO:0046903 ! secretion +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:0032310 +name: prostaglandin secretion +namespace: biological_process +def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue." [GOC:mah] +synonym: "prostacyclin secretion" NARROW [] +is_a: GO:0015732 ! prostaglandin transport +is_a: GO:0023061 ! signal release +is_a: GO:0032309 ! icosanoid secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0032311 +name: angiogenin-PRI complex +namespace: cellular_component +def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] +synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0032322 +name: ubiquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] +synonym: "ubiquinone breakdown" EXACT [] +synonym: "ubiquinone catabolism" EXACT [] +synonym: "ubiquinone degradation" EXACT [] +is_a: GO:0006743 ! ubiquinone metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:0032323 +name: lipoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah] +synonym: "lipoic acid breakdown" EXACT [] +synonym: "lipoic acid catabolism" EXACT [] +synonym: "lipoic acid degradation" EXACT [] +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0009106 ! lipoate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0032324 +name: molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] +synonym: "molybdopterin cofactor anabolism" EXACT [] +synonym: "molybdopterin cofactor biosynthesis" RELATED [] +synonym: "molybdopterin cofactor formation" RELATED [] +synonym: "molybdopterin cofactor synthesis" EXACT [] +xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043545 ! molybdopterin cofactor metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0032325 +name: molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0032326 +name: Mo-molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah] +synonym: "Mo-molybdopterin cofactor breakdown" EXACT [] +synonym: "Mo-molybdopterin cofactor catabolism" EXACT [] +synonym: "Mo-molybdopterin cofactor degradation" EXACT [] +synonym: "Moco catabolic process" BROAD [] +synonym: "Moco catabolism" BROAD [] +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process +is_a: GO:0032325 ! molybdopterin cofactor catabolic process + +[Term] +id: GO:0032327 +name: W-molybdopterin cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah] +synonym: "Moco catabolic process" BROAD [] +synonym: "Moco catabolism" BROAD [] +synonym: "W-molybdopterin cofactor breakdown" EXACT [] +synonym: "W-molybdopterin cofactor catabolism" EXACT [] +synonym: "W-molybdopterin cofactor degradation" EXACT [] +is_a: GO:0032325 ! molybdopterin cofactor catabolic process +is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process + +[Term] +id: GO:0032328 +name: alanine transport +namespace: biological_process +def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0006812 ! cation transport +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0032329 +name: serine transport +namespace: biological_process +alt_id: GO:0090478 +def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "serine import" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0032330 +name: regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0061035 ! regulation of cartilage development +relationship: regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032331 +name: negative regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +synonym: "down regulation of chondrocyte differentiation" EXACT [] +synonym: "down-regulation of chondrocyte differentiation" EXACT [] +synonym: "downregulation of chondrocyte differentiation" EXACT [] +synonym: "inhibition of chondrocyte differentiation" NARROW [] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0061037 ! negative regulation of cartilage development +relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032332 +name: positive regulation of chondrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] +synonym: "activation of chondrocyte differentiation" NARROW [] +synonym: "stimulation of chondrocyte differentiation" NARROW [] +synonym: "up regulation of chondrocyte differentiation" EXACT [] +synonym: "up-regulation of chondrocyte differentiation" EXACT [] +synonym: "upregulation of chondrocyte differentiation" EXACT [] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0061036 ! positive regulation of cartilage development +relationship: positively_regulates GO:0002062 ! chondrocyte differentiation + +[Term] +id: GO:0032333 +name: activin secretion +namespace: biological_process +def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah] +is_a: GO:0046879 ! hormone secretion + +[Term] +id: GO:0032334 +name: inhibin secretion +namespace: biological_process +def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah] +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0032335 +name: regulation of activin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032336 +name: negative regulation of activin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] +synonym: "down regulation of activin secretion" EXACT [] +synonym: "down-regulation of activin secretion" EXACT [] +synonym: "downregulation of activin secretion" EXACT [] +synonym: "inhibition of activin secretion" NARROW [] +is_a: GO:0032335 ! regulation of activin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +relationship: negatively_regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032337 +name: positive regulation of activin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] +synonym: "activation of activin secretion" NARROW [] +synonym: "stimulation of activin secretion" NARROW [] +synonym: "up regulation of activin secretion" EXACT [] +synonym: "up-regulation of activin secretion" EXACT [] +synonym: "upregulation of activin secretion" EXACT [] +is_a: GO:0032335 ! regulation of activin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0032333 ! activin secretion + +[Term] +id: GO:0032338 +name: regulation of inhibin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032339 +name: negative regulation of inhibin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] +synonym: "down regulation of inhibin secretion" EXACT [] +synonym: "down-regulation of inhibin secretion" EXACT [] +synonym: "downregulation of inhibin secretion" EXACT [] +synonym: "inhibition of inhibin secretion" NARROW [] +is_a: GO:0032338 ! regulation of inhibin secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032340 +name: positive regulation of inhibin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] +synonym: "activation of inhibin secretion" NARROW [] +synonym: "stimulation of inhibin secretion" NARROW [] +synonym: "up regulation of inhibin secretion" EXACT [] +synonym: "up-regulation of inhibin secretion" EXACT [] +synonym: "upregulation of inhibin secretion" EXACT [] +is_a: GO:0032338 ! regulation of inhibin secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0032334 ! inhibin secretion + +[Term] +id: GO:0032341 +name: aldosterone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +synonym: "aldosterone metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0008212 ! mineralocorticoid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0032342 +name: aldosterone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +is_a: GO:0006700 ! C21-steroid hormone biosynthetic process +is_a: GO:0006705 ! mineralocorticoid biosynthetic process +is_a: GO:0032341 ! aldosterone metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:0032343 +name: aldosterone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] +is_a: GO:0006712 ! mineralocorticoid catabolic process +is_a: GO:0008208 ! C21-steroid hormone catabolic process +is_a: GO:0032341 ! aldosterone metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0032344 +name: regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "regulation of aldosterone metabolism" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032345 +name: negative regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "down regulation of aldosterone metabolic process" EXACT [] +synonym: "down-regulation of aldosterone metabolic process" EXACT [] +synonym: "downregulation of aldosterone metabolic process" EXACT [] +synonym: "inhibition of aldosterone metabolic process" NARROW [] +synonym: "negative regulation of aldosterone metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032346 +name: positive regulation of aldosterone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] +synonym: "activation of aldosterone metabolic process" NARROW [] +synonym: "positive regulation of aldosterone metabolism" EXACT [] +synonym: "stimulation of aldosterone metabolic process" NARROW [] +synonym: "up regulation of aldosterone metabolic process" EXACT [] +synonym: "up-regulation of aldosterone metabolic process" EXACT [] +synonym: "upregulation of aldosterone metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0032341 ! aldosterone metabolic process + +[Term] +id: GO:0032347 +name: regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0032344 ! regulation of aldosterone metabolic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032348 +name: negative regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +synonym: "down regulation of aldosterone biosynthetic process" EXACT [] +synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] +synonym: "downregulation of aldosterone biosynthetic process" EXACT [] +synonym: "inhibition of aldosterone biosynthetic process" NARROW [] +is_a: GO:0032345 ! negative regulation of aldosterone metabolic process +is_a: GO:0032347 ! regulation of aldosterone biosynthetic process +is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032349 +name: positive regulation of aldosterone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] +synonym: "activation of aldosterone biosynthetic process" NARROW [] +synonym: "stimulation of aldosterone biosynthetic process" NARROW [] +synonym: "up regulation of aldosterone biosynthetic process" EXACT [] +synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] +synonym: "upregulation of aldosterone biosynthetic process" EXACT [] +is_a: GO:0032346 ! positive regulation of aldosterone metabolic process +is_a: GO:0032347 ! regulation of aldosterone biosynthetic process +is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process + +[Term] +id: GO:0032350 +name: regulation of hormone metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "regulation of hormone metabolism" EXACT [] +is_a: GO:0010817 ! regulation of hormone levels +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032351 +name: negative regulation of hormone metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "down regulation of hormone metabolic process" EXACT [] +synonym: "down-regulation of hormone metabolic process" EXACT [] +synonym: "downregulation of hormone metabolic process" EXACT [] +synonym: "inhibition of hormone metabolic process" NARROW [] +synonym: "negative regulation of hormone metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: negatively_regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032352 +name: positive regulation of hormone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] +synonym: "activation of hormone metabolic process" NARROW [] +synonym: "positive regulation of hormone metabolism" EXACT [] +synonym: "stimulation of hormone metabolic process" NARROW [] +synonym: "up regulation of hormone metabolic process" EXACT [] +synonym: "up-regulation of hormone metabolic process" EXACT [] +synonym: "upregulation of hormone metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: positively_regulates GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0032353 +name: negative regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "down regulation of hormone biosynthetic process" EXACT [] +synonym: "down-regulation of hormone biosynthetic process" EXACT [] +synonym: "downregulation of hormone biosynthetic process" EXACT [] +synonym: "inhibition of hormone biosynthetic process" NARROW [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0032354 +name: response to follicle-stimulating hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] +synonym: "response to follicle stimulating hormone stimulus" EXACT [] +synonym: "response to follicle-stimulating hormone stimulus" EXACT [GOC:dos] +synonym: "response to FSH stimulus" EXACT [] +is_a: GO:0034698 ! response to gonadotropin + +[Term] +id: GO:0032355 +name: response to estradiol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] +synonym: "response to E2 stimulus" EXACT [] +synonym: "response to estradiol stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0032356 +name: oxidized DNA binding +namespace: molecular_function +def: "Binding to a DNA region containing an oxidized residue." [GOC:vk] +synonym: "oxidised DNA binding" EXACT [] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:0032357 +name: oxidized purine DNA binding +namespace: molecular_function +def: "Binding to a DNA region containing an oxidized purine residue." [GOC:vk] +synonym: "oxidised purine DNA binding" EXACT [] +synonym: "oxidized purine base DNA binding" EXACT [] +synonym: "oxidized purine nucleobase DNA binding" EXACT [] +is_a: GO:0032356 ! oxidized DNA binding + +[Term] +id: GO:0032358 +name: oxidized pyrimidine DNA binding +namespace: molecular_function +def: "Binding to a DNA region containing an oxidized pyrimidine residue." [GOC:vk] +synonym: "oxidised pyrimidine DNA binding" EXACT [] +synonym: "oxidized pyrimidine base DNA binding" EXACT [] +synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT [] +is_a: GO:0032356 ! oxidized DNA binding + +[Term] +id: GO:0032359 +name: provirus excision +namespace: biological_process +def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] +synonym: "prophage excision" EXACT [] +is_a: GO:0019046 ! release from viral latency + +[Term] +id: GO:0032361 +name: pyridoxal phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042820 ! vitamin B6 catabolic process +is_a: GO:0042822 ! pyridoxal phosphate metabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0032362 +name: obsolete FAD catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [GOC:mah] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "FAD breakdown" EXACT [GOC:mah] +synonym: "FAD catabolism" EXACT [GOC:mah] +synonym: "FAD degradation" EXACT [GOC:mah] +synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0032363 +name: FMN catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] +is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process +is_a: GO:0009261 ! ribonucleotide catabolic process +is_a: GO:0042728 ! flavin-containing compound catabolic process +is_a: GO:0046444 ! FMN metabolic process + +[Term] +id: GO:0032364 +name: oxygen homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell." [GOC:rph] +is_a: GO:0033483 ! gas homeostasis + +[Term] +id: GO:0032365 +name: intracellular lipid transport +namespace: biological_process +def: "The directed movement of lipids within cells." [GOC:mah] +is_a: GO:0006869 ! lipid transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0032366 +name: intracellular sterol transport +namespace: biological_process +def: "The directed movement of sterols within cells." [GOC:mah] +is_a: GO:0015918 ! sterol transport +is_a: GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032367 +name: intracellular cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah] +is_a: GO:0030301 ! cholesterol transport +is_a: GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032368 +name: regulation of lipid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +is_a: GO:1905952 ! regulation of lipid localization +relationship: regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032369 +name: negative regulation of lipid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of lipid transport" EXACT [] +synonym: "down-regulation of lipid transport" EXACT [] +synonym: "downregulation of lipid transport" EXACT [] +synonym: "inhibition of lipid transport" NARROW [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1905953 ! negative regulation of lipid localization +relationship: negatively_regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032370 +name: positive regulation of lipid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of lipid transport" NARROW [] +synonym: "stimulation of lipid transport" NARROW [] +synonym: "up regulation of lipid transport" EXACT [] +synonym: "up-regulation of lipid transport" EXACT [] +synonym: "upregulation of lipid transport" EXACT [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1905954 ! positive regulation of lipid localization +relationship: positively_regulates GO:0006869 ! lipid transport + +[Term] +id: GO:0032371 +name: regulation of sterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032368 ! regulation of lipid transport +relationship: regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032372 +name: negative regulation of sterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of sterol transport" EXACT [] +synonym: "down-regulation of sterol transport" EXACT [] +synonym: "downregulation of sterol transport" EXACT [] +synonym: "inhibition of sterol transport" NARROW [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032371 ! regulation of sterol transport +relationship: negatively_regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032373 +name: positive regulation of sterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of sterol transport" NARROW [] +synonym: "stimulation of sterol transport" NARROW [] +synonym: "up regulation of sterol transport" EXACT [] +synonym: "up-regulation of sterol transport" EXACT [] +synonym: "upregulation of sterol transport" EXACT [] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032371 ! regulation of sterol transport +relationship: positively_regulates GO:0015918 ! sterol transport + +[Term] +id: GO:0032374 +name: regulation of cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0032371 ! regulation of sterol transport +relationship: regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032375 +name: negative regulation of cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of cholesterol transport" EXACT [] +synonym: "down-regulation of cholesterol transport" EXACT [] +synonym: "downregulation of cholesterol transport" EXACT [] +synonym: "inhibition of cholesterol transport" NARROW [] +is_a: GO:0032372 ! negative regulation of sterol transport +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: negatively_regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032376 +name: positive regulation of cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of cholesterol transport" NARROW [] +synonym: "stimulation of cholesterol transport" NARROW [] +synonym: "up regulation of cholesterol transport" EXACT [] +synonym: "up-regulation of cholesterol transport" EXACT [] +synonym: "upregulation of cholesterol transport" EXACT [] +is_a: GO:0032373 ! positive regulation of sterol transport +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: positively_regulates GO:0030301 ! cholesterol transport + +[Term] +id: GO:0032377 +name: regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032378 +name: negative regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +synonym: "down regulation of intracellular lipid transport" EXACT [] +synonym: "down-regulation of intracellular lipid transport" EXACT [] +synonym: "downregulation of intracellular lipid transport" EXACT [] +synonym: "inhibition of intracellular lipid transport" NARROW [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +is_a: GO:0032387 ! negative regulation of intracellular transport +relationship: negatively_regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032379 +name: positive regulation of intracellular lipid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] +synonym: "activation of intracellular lipid transport" NARROW [] +synonym: "stimulation of intracellular lipid transport" NARROW [] +synonym: "up regulation of intracellular lipid transport" EXACT [] +synonym: "up-regulation of intracellular lipid transport" EXACT [] +synonym: "upregulation of intracellular lipid transport" EXACT [] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +is_a: GO:0032388 ! positive regulation of intracellular transport +relationship: positively_regulates GO:0032365 ! intracellular lipid transport + +[Term] +id: GO:0032380 +name: regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +is_a: GO:0032371 ! regulation of sterol transport +is_a: GO:0032377 ! regulation of intracellular lipid transport +relationship: regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032381 +name: negative regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +synonym: "down regulation of intracellular sterol transport" EXACT [] +synonym: "down-regulation of intracellular sterol transport" EXACT [] +synonym: "downregulation of intracellular sterol transport" EXACT [] +synonym: "inhibition of intracellular sterol transport" NARROW [] +is_a: GO:0032372 ! negative regulation of sterol transport +is_a: GO:0032378 ! negative regulation of intracellular lipid transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: negatively_regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032382 +name: positive regulation of intracellular sterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] +synonym: "activation of intracellular sterol transport" NARROW [] +synonym: "stimulation of intracellular sterol transport" NARROW [] +synonym: "up regulation of intracellular sterol transport" EXACT [] +synonym: "up-regulation of intracellular sterol transport" EXACT [] +synonym: "upregulation of intracellular sterol transport" EXACT [] +is_a: GO:0032373 ! positive regulation of sterol transport +is_a: GO:0032379 ! positive regulation of intracellular lipid transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: positively_regulates GO:0032366 ! intracellular sterol transport + +[Term] +id: GO:0032383 +name: regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +is_a: GO:0032374 ! regulation of cholesterol transport +is_a: GO:0032380 ! regulation of intracellular sterol transport +relationship: regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032384 +name: negative regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +synonym: "down regulation of intracellular cholesterol transport" EXACT [] +synonym: "down-regulation of intracellular cholesterol transport" EXACT [] +synonym: "downregulation of intracellular cholesterol transport" EXACT [] +synonym: "inhibition of intracellular cholesterol transport" NARROW [] +is_a: GO:0032375 ! negative regulation of cholesterol transport +is_a: GO:0032381 ! negative regulation of intracellular sterol transport +is_a: GO:0032383 ! regulation of intracellular cholesterol transport +relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032385 +name: positive regulation of intracellular cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] +synonym: "activation of intracellular cholesterol transport" NARROW [] +synonym: "stimulation of intracellular cholesterol transport" NARROW [] +synonym: "up regulation of intracellular cholesterol transport" EXACT [] +synonym: "up-regulation of intracellular cholesterol transport" EXACT [] +synonym: "upregulation of intracellular cholesterol transport" EXACT [] +is_a: GO:0032376 ! positive regulation of cholesterol transport +is_a: GO:0032382 ! positive regulation of intracellular sterol transport +is_a: GO:0032383 ! regulation of intracellular cholesterol transport +relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0032386 +name: regulation of intracellular transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032387 +name: negative regulation of intracellular transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +synonym: "down regulation of intracellular transport" EXACT [] +synonym: "down-regulation of intracellular transport" EXACT [] +synonym: "downregulation of intracellular transport" EXACT [] +synonym: "inhibition of intracellular transport" NARROW [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032388 +name: positive regulation of intracellular transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] +synonym: "activation of intracellular transport" NARROW [] +synonym: "stimulation of intracellular transport" NARROW [] +synonym: "up regulation of intracellular transport" EXACT [] +synonym: "up-regulation of intracellular transport" EXACT [] +synonym: "upregulation of intracellular transport" EXACT [] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0032389 +name: MutLalpha complex +namespace: cellular_component +def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] +synonym: "MLH1/PMS2 complex" EXACT [] +synonym: "MMR complex" BROAD [] +synonym: "MutL-alpha complex" EXACT [CORUM:292] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032390 +name: MutLbeta complex +namespace: cellular_component +def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] +synonym: "MLH1/PMS1 complex" EXACT [] +synonym: "MMR complex" BROAD [] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032391 +name: photoreceptor connecting cilium +namespace: cellular_component +def: "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680] +synonym: "photoreceptor cilium" RELATED [] +is_a: GO:0035869 ! ciliary transition zone +relationship: part_of GO:0097733 ! photoreceptor cell cilium + +[Term] +id: GO:0032392 +name: DNA geometric change +namespace: biological_process +def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] +comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. +subset: goslim_pir +is_a: GO:0071103 ! DNA conformation change + +[Term] +id: GO:0032393 +name: MHC class I receptor activity +namespace: molecular_function +def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0032394 +name: MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0032395 +name: MHC class II receptor activity +namespace: molecular_function +def: "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] +comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0032396 +name: inhibitory MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] +is_a: GO:0032393 ! MHC class I receptor activity + +[Term] +id: GO:0032397 +name: activating MHC class I receptor activity +namespace: molecular_function +def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] +is_a: GO:0032393 ! MHC class I receptor activity + +[Term] +id: GO:0032398 +name: MHC class Ib protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678] +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0032399 +name: HECT domain binding +namespace: molecular_function +def: "Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032400 +name: melanosome localization +namespace: biological_process +def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] +synonym: "melanosome localisation" EXACT [GOC:mah] +is_a: GO:0051875 ! pigment granule localization + +[Term] +id: GO:0032401 +name: establishment of melanosome localization +namespace: biological_process +def: "The directed movement of a melanosome to a specific location." [GOC:mah] +synonym: "establishment of melanosome localisation" EXACT [GOC:mah] +is_a: GO:0051905 ! establishment of pigment granule localization +relationship: part_of GO:0032400 ! melanosome localization + +[Term] +id: GO:0032402 +name: melanosome transport +namespace: biological_process +def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] +is_a: GO:0032400 ! melanosome localization +is_a: GO:0032401 ! establishment of melanosome localization +is_a: GO:0051904 ! pigment granule transport + +[Term] +id: GO:0032404 +name: mismatch repair complex binding +namespace: molecular_function +def: "Binding to a mismatch repair complex." [GOC:vk] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0032405 +name: MutLalpha complex binding +namespace: molecular_function +def: "Binding to a MutLalpha mismatch repair complex." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032406 +name: MutLbeta complex binding +namespace: molecular_function +def: "Binding to a MutLbeta mismatch repair complex." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032407 +name: MutSalpha complex binding +namespace: molecular_function +def: "Binding to a MutSalpha mismatch repair complex." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032408 +name: MutSbeta complex binding +namespace: molecular_function +def: "Binding to a MutSbeta mismatch repair complex." [GOC:vk] +is_a: GO:0032404 ! mismatch repair complex binding + +[Term] +id: GO:0032409 +name: regulation of transporter activity +namespace: biological_process +def: "Any process that modulates the activity of a transporter." [GOC:mah] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0032410 +name: negative regulation of transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] +synonym: "down regulation of transporter activity" EXACT [] +synonym: "down-regulation of transporter activity" EXACT [] +synonym: "downregulation of transporter activity" EXACT [] +synonym: "inhibition of transporter activity" NARROW [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0051051 ! negative regulation of transport + +[Term] +id: GO:0032411 +name: positive regulation of transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of a transporter." [GOC:mah] +synonym: "activation of transporter activity" NARROW [] +synonym: "stimulation of transporter activity" NARROW [] +synonym: "up regulation of transporter activity" EXACT [] +synonym: "up-regulation of transporter activity" EXACT [] +synonym: "upregulation of transporter activity" EXACT [] +is_a: GO:0032409 ! regulation of transporter activity +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0051050 ! positive regulation of transport + +[Term] +id: GO:0032412 +name: regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0022898 ! regulation of transmembrane transporter activity +is_a: GO:0034765 ! regulation of ion transmembrane transport + +[Term] +id: GO:0032413 +name: negative regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "down regulation of ion transporter activity" EXACT [] +synonym: "down-regulation of ion transporter activity" EXACT [] +synonym: "downregulation of ion transporter activity" EXACT [] +synonym: "inhibition of ion transporter activity" NARROW [] +synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034766 ! negative regulation of ion transmembrane transport + +[Term] +id: GO:0032414 +name: positive regulation of ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] +synonym: "activation of ion transporter activity" NARROW [] +synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] +synonym: "stimulation of ion transporter activity" NARROW [] +synonym: "up regulation of ion transporter activity" EXACT [] +synonym: "up-regulation of ion transporter activity" EXACT [] +synonym: "upregulation of ion transporter activity" EXACT [] +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034767 ! positive regulation of ion transmembrane transport + +[Term] +id: GO:0032415 +name: regulation of sodium:proton antiporter activity +namespace: biological_process +def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport] +synonym: "regulation of sodium:hydrogen antiporter activity" EXACT [] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:0032416 +name: negative regulation of sodium:proton antiporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] +synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW [] +synonym: "negative regulation of sodium:hydrogen antiporter activity" EXACT [] +is_a: GO:0032415 ! regulation of sodium:proton antiporter activity +is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:0032417 +name: positive regulation of sodium:proton antiporter activity +namespace: biological_process +def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] +synonym: "activation of sodium:hydrogen antiporter activity" NARROW [] +synonym: "positive regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW [] +synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT [] +synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT [] +is_a: GO:0032415 ! regulation of sodium:proton antiporter activity +is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:0032418 +name: lysosome localization +namespace: biological_process +def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] +synonym: "lysosome localisation" EXACT [GOC:mah] +is_a: GO:1990849 ! vacuolar localization + +[Term] +id: GO:0032419 +name: extrinsic component of lysosome membrane +namespace: cellular_component +def: "The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] +synonym: "extrinsic to lysosomal membrane" EXACT [] +synonym: "extrinsic to lysosome membrane" EXACT [] +is_a: GO:0000306 ! extrinsic component of vacuolar membrane +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0032420 +name: stereocilium +namespace: cellular_component +def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] +is_a: GO:0043005 ! neuron projection +is_a: GO:0098858 ! actin-based cell projection +relationship: part_of GO:0032421 ! stereocilium bundle +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0032421 +name: stereocilium bundle +namespace: cellular_component +def: "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] +subset: goslim_pir +synonym: "stereocilia bundle" EXACT [] +is_a: GO:0098862 ! cluster of actin-based cell projections + +[Term] +id: GO:0032422 +name: purine-rich negative regulatory element binding +namespace: molecular_function +def: "Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] +synonym: "PNR element binding" BROAD [] +is_a: GO:0000976 ! transcription cis-regulatory region binding + +[Term] +id: GO:0032423 +name: regulation of mismatch repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk] +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032424 +name: negative regulation of mismatch repair +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk] +synonym: "down regulation of mismatch repair" EXACT [] +synonym: "down-regulation of mismatch repair" EXACT [] +synonym: "downregulation of mismatch repair" EXACT [] +synonym: "inhibition of mismatch repair" NARROW [] +is_a: GO:0032423 ! regulation of mismatch repair +is_a: GO:0045738 ! negative regulation of DNA repair +relationship: negatively_regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032425 +name: positive regulation of mismatch repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk] +synonym: "activation of mismatch repair" NARROW [] +synonym: "stimulation of mismatch repair" NARROW [] +synonym: "up regulation of mismatch repair" EXACT [] +synonym: "up-regulation of mismatch repair" EXACT [] +synonym: "upregulation of mismatch repair" EXACT [] +is_a: GO:0032423 ! regulation of mismatch repair +is_a: GO:0045739 ! positive regulation of DNA repair +relationship: positively_regulates GO:0006298 ! mismatch repair + +[Term] +id: GO:0032426 +name: stereocilium tip +namespace: cellular_component +def: "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0032427 +name: GBD domain binding +namespace: molecular_function +def: "Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069] +synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069] +synonym: "CRIB motif binding" EXACT [PMID:9119069] +synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl] +synonym: "PMD binding" EXACT [GOC:rl] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0032428 +name: beta-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] +xref: EC:3.2.1.53 +xref: MetaCyc:3.2.1.53-RXN +is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity + +[Term] +id: GO:0032429 +name: regulation of phospholipase A2 activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah] +is_a: GO:0010517 ! regulation of phospholipase activity + +[Term] +id: GO:0032430 +name: positive regulation of phospholipase A2 activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah] +synonym: "activation of phospholipase A2 activity" NARROW [] +synonym: "stimulation of phospholipase A2 activity" NARROW [] +synonym: "up regulation of phospholipase A2 activity" EXACT [] +synonym: "up-regulation of phospholipase A2 activity" EXACT [] +synonym: "upregulation of phospholipase A2 activity" EXACT [] +is_a: GO:0010518 ! positive regulation of phospholipase activity +is_a: GO:0032429 ! regulation of phospholipase A2 activity + +[Term] +id: GO:0032431 +name: activation of phospholipase A2 activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah] +synonym: "phospholipase A2 activation" EXACT [] +is_a: GO:0032430 ! positive regulation of phospholipase A2 activity + +[Term] +id: GO:0032432 +name: actin filament bundle +namespace: cellular_component +alt_id: GO:0000141 +alt_id: GO:0030482 +def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] +synonym: "actin cable" RELATED [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0032433 +name: filopodium tip +namespace: cellular_component +def: "The end of a filopodium distal to the body of the cell." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030175 ! filopodium + +[Term] +id: GO:0032434 +name: regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +is_a: GO:0061136 ! regulation of proteasomal protein catabolic process +is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process +relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032435 +name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process +is_a: GO:2000059 ! negative regulation of ubiquitin-dependent protein catabolic process +relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032436 +name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] +synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process +is_a: GO:2000060 ! positive regulation of ubiquitin-dependent protein catabolic process +relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0032437 +name: cuticular plate +namespace: cellular_component +def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:0032438 +name: melanosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] +synonym: "melanosome organisation" EXACT [GOC:mah] +synonym: "melanosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0048753 ! pigment granule organization + +[Term] +id: GO:0032440 +name: 2-alkenal reductase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] +synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.3.1.74] +synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" RELATED [EC:1.3.1.74] +xref: EC:1.3.1.74 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032441 +name: pheophorbide a oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372] +xref: EC:1.14.15.17 +xref: MetaCyc:RXN-7740 +xref: RHEA:48140 +is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors + +[Term] +id: GO:0032442 +name: phenylcoumaran benzylic ether reductase activity +namespace: molecular_function +def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+." [PMID:11030549, PMID:13129921] +synonym: "PCBER activity" EXACT [] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0032443 +name: regulation of ergosterol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0106118 ! regulation of sterol biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0006696 ! ergosterol biosynthetic process + +[Term] +id: GO:0032444 +name: activin responsive factor complex +namespace: cellular_component +def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] +comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). +synonym: "ARF complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0032445 +name: fructose import +namespace: biological_process +def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah] +synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015755 ! fructose transmembrane transport + +[Term] +id: GO:0032446 +name: protein modification by small protein conjugation +namespace: biological_process +def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] +is_a: GO:0070647 ! protein modification by small protein conjugation or removal + +[Term] +id: GO:0032447 +name: protein urmylation +namespace: biological_process +def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0032448 +name: DNA hairpin binding +namespace: molecular_function +def: "Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0032449 +name: CBM complex +namespace: cellular_component +def: "A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation." [PMID:12909454, PMID:30467369] +synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032450 +name: maltose alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] +synonym: "maltase activity" EXACT [] +xref: EC:3.2.1.20 +xref: MetaCyc:RXN-2141 +is_a: GO:0004558 ! alpha-1,4-glucosidase activity + +[Term] +id: GO:0032451 +name: demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] +subset: goslim_pir +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0032452 +name: histone demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] +xref: Reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3" +xref: Reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3" +xref: Reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3" +xref: Reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3" +xref: Reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3" +xref: Reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3" +xref: Reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3" +xref: Reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4" +xref: Reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters" +xref: Reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters" +xref: Reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters" +xref: Reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A demethylate Me2K37-histone H3" +xref: Reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3" +xref: Reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3" +xref: Reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3" +xref: Reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3" +xref: Reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3" +xref: Reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3" +xref: Reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4" +xref: Reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4" +is_a: GO:0140457 ! protein demethylase activity + +[Term] +id: GO:0032453 +name: histone H3-methyl-lysine-4 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein." [GOC:mah] +synonym: "histone demethylase activity (H3-K4 specific)" EXACT [] +synonym: "histone H3K4 demethylase activity" EXACT [] +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0032454 +name: histone H3-methyl-lysine-9 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein." [PMID:16362057] +synonym: "H3K49 demethylase activity" EXACT [] +synonym: "histone demethylase activity (H3-K9 specific)" EXACT [] +xref: Reactome:R-HSA-9011949 "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers" +xref: Reactome:R-HSA-9011985 "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen" +xref: Reactome:R-HSA-997263 "JMJD1C demethylates H3K9 mono- and di-methylation" +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0032455 +name: nerve growth factor processing +namespace: biological_process +def: "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor." [GOC:mah, PMID:8615794] +synonym: "beta-nerve growth factor processing" EXACT [PR:000011194] +synonym: "NGF processing" EXACT [PR:000011194] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0032456 +name: endocytic recycling +namespace: biological_process +alt_id: GO:1990126 +def: "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:16473635, PMID:23563491] +synonym: "retrograde transport of endocytic vesicles" RELATED [] +synonym: "retrograde transport, endosome to plasma membrane" EXACT [] +is_a: GO:0016197 ! endosomal transport +is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane + +[Term] +id: GO:0032457 +name: fast endocytic recycling +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] +synonym: "direct endocytic recycling" EXACT [] +is_a: GO:0032456 ! endocytic recycling + +[Term] +id: GO:0032458 +name: slow endocytic recycling +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] +is_a: GO:0032456 ! endocytic recycling + +[Term] +id: GO:0032459 +name: regulation of protein oligomerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0032460 +name: negative regulation of protein oligomerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah] +synonym: "down regulation of protein oligomerization" EXACT [] +synonym: "down-regulation of protein oligomerization" EXACT [] +synonym: "downregulation of protein oligomerization" EXACT [] +synonym: "inhibition of protein oligomerization" NARROW [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: negatively_regulates GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0032461 +name: positive regulation of protein oligomerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah] +synonym: "activation of protein oligomerization" NARROW [] +synonym: "induction of protein oligomerization" RELATED [] +synonym: "stimulation of protein oligomerization" NARROW [] +synonym: "up regulation of protein oligomerization" EXACT [] +synonym: "up-regulation of protein oligomerization" EXACT [] +synonym: "upregulation of protein oligomerization" EXACT [] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: positively_regulates GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0032462 +name: regulation of protein homooligomerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah] +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032463 +name: negative regulation of protein homooligomerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah] +synonym: "down regulation of protein homooligomerization" EXACT [] +synonym: "down-regulation of protein homooligomerization" EXACT [] +synonym: "downregulation of protein homooligomerization" EXACT [] +synonym: "inhibition of protein homooligomerization" NARROW [] +is_a: GO:0032460 ! negative regulation of protein oligomerization +is_a: GO:0032462 ! regulation of protein homooligomerization +relationship: negatively_regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032464 +name: positive regulation of protein homooligomerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah] +synonym: "activation of protein homooligomerization" NARROW [] +synonym: "induction of protein homooligomerization" RELATED [] +synonym: "stimulation of protein homooligomerization" NARROW [] +synonym: "up regulation of protein homooligomerization" EXACT [] +synonym: "up-regulation of protein homooligomerization" EXACT [] +synonym: "upregulation of protein homooligomerization" EXACT [] +is_a: GO:0032461 ! positive regulation of protein oligomerization +is_a: GO:0032462 ! regulation of protein homooligomerization +relationship: positively_regulates GO:0051260 ! protein homooligomerization + +[Term] +id: GO:0032465 +name: regulation of cytokinesis +namespace: biological_process +alt_id: GO:0071775 +def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] +synonym: "regulation of cell cycle cytokinesis" EXACT [] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032466 +name: negative regulation of cytokinesis +namespace: biological_process +alt_id: GO:0071776 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] +synonym: "down regulation of cytokinesis" EXACT [] +synonym: "down-regulation of cytokinesis" EXACT [] +synonym: "downregulation of cytokinesis" EXACT [] +synonym: "inhibition of cytokinesis" NARROW [] +synonym: "negative regulation of cell cycle cytokinesis" RELATED [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0032465 ! regulation of cytokinesis +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032467 +name: positive regulation of cytokinesis +namespace: biological_process +alt_id: GO:0071777 +def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] +synonym: "activation of cytokinesis" NARROW [] +synonym: "positive regulation of cell cycle cytokinesis" RELATED [] +synonym: "stimulation of cytokinesis" NARROW [] +synonym: "up regulation of cytokinesis" EXACT [] +synonym: "up-regulation of cytokinesis" EXACT [] +synonym: "upregulation of cytokinesis" EXACT [] +is_a: GO:0032465 ! regulation of cytokinesis +is_a: GO:0051781 ! positive regulation of cell division +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0000910 ! cytokinesis + +[Term] +id: GO:0032468 +name: Golgi calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] +synonym: "calcium ion homeostasis in Golgi" EXACT [] +synonym: "Golgi calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in Golgi" EXACT [] +synonym: "regulation of Golgi calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0032469 +name: endoplasmic reticulum calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] +synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] +synonym: "calcium ion homeostasis in ER" EXACT [] +synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] +synonym: "ER calcium ion concentration regulation" EXACT [] +synonym: "ER calcium ion homeostasis" EXACT [] +synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "regulation of calcium ion concentration in ER" EXACT [] +synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "regulation of ER calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0032470 +name: positive regulation of endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] +synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "elevation of endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "elevation of ER calcium ion concentration" EXACT [] +synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0032471 +name: negative regulation of endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] +synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT [] +synonym: "ER calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT [] +synonym: "reduction of calcium ion concentration in ER" EXACT [] +synonym: "reduction of endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "reduction of ER calcium ion concentration" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0032472 +name: Golgi calcium ion transport +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] +synonym: "Golgi calcium transport" EXACT [] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0032473 +name: cytoplasmic side of mitochondrial outer membrane +namespace: cellular_component +def: "The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah] +comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. +synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] +synonym: "external leaflet of mitochondrial outer membrane" EXACT [GOC:ab] +synonym: "external side of mitochondrial envelope" RELATED [] +synonym: "external side of mitochondrial outer membrane" EXACT [] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0032474 +name: otolith morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0048840 ! otolith development + +[Term] +id: GO:0032475 +name: otolith formation +namespace: biological_process +def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0032474 ! otolith morphogenesis + +[Term] +id: GO:0032476 +name: decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] +subset: goslim_pir +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0032477 +name: homodimeric decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] +is_a: GO:0032476 ! decaprenyl diphosphate synthase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032478 +name: heterotetrameric decaprenyl diphosphate synthase complex +namespace: cellular_component +def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] +is_a: GO:0032476 ! decaprenyl diphosphate synthase complex +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0032479 +name: regulation of type I interferon production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "regulation of type I IFN production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032480 +name: negative regulation of type I interferon production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "down regulation of type I interferon production" EXACT [] +synonym: "down-regulation of type I interferon production" EXACT [] +synonym: "downregulation of type I interferon production" EXACT [] +synonym: "inhibition of type I interferon production" NARROW [] +synonym: "negative regulation of type I IFN production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032479 ! regulation of type I interferon production +relationship: negatively_regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032481 +name: positive regulation of type I interferon production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] +synonym: "activation of type I interferon production" NARROW [] +synonym: "positive regulation of type I IFN production" EXACT [] +synonym: "stimulation of type I interferon production" NARROW [] +synonym: "up regulation of type I interferon production" EXACT [] +synonym: "up-regulation of type I interferon production" EXACT [] +synonym: "upregulation of type I interferon production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032479 ! regulation of type I interferon production +relationship: positively_regulates GO:0032606 ! type I interferon production + +[Term] +id: GO:0032482 +name: Rab protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032483 +name: regulation of Rab protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032482 ! Rab protein signal transduction + +[Term] +id: GO:0032484 +name: Ral protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032485 +name: regulation of Ral protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032484 ! Ral protein signal transduction + +[Term] +id: GO:0032486 +name: Rap protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] +is_a: GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0032487 +name: regulation of Rap protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0032486 ! Rap protein signal transduction + +[Term] +id: GO:0032488 +name: Cdc42 protein signal transduction +namespace: biological_process +def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah, PMID:18558478] +synonym: "Cdc42 signaling" RELATED [GOC:vw] +synonym: "Cdc42 signaling pathway" RELATED [GOC:vw] +synonym: "cdc42 signalling pathway" RELATED [GOC:vw] +is_a: GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0032489 +name: regulation of Cdc42 protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +relationship: regulates GO:0032488 ! Cdc42 protein signal transduction + +[Term] +id: GO:0032490 +name: detection of molecule of bacterial origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl] +synonym: "detection of bacteria associated molecule" EXACT [] +synonym: "detection of bacterial associated molecule" EXACT [] +synonym: "detection of bacterium associated molecule" EXACT [] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0098581 ! detection of external biotic stimulus + +[Term] +id: GO:0032491 +name: detection of molecule of fungal origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] +synonym: "detection of fungal associated molecule" EXACT [] +synonym: "detection of fungus associated molecule" EXACT [] +is_a: GO:0002238 ! response to molecule of fungal origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0098581 ! detection of external biotic stimulus + +[Term] +id: GO:0032492 +name: detection of molecule of oomycetes origin +namespace: biological_process +def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] +synonym: "detection of oomycetes associated molecule" EXACT [] +is_a: GO:0002240 ! response to molecule of oomycetes origin +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0098581 ! detection of external biotic stimulus + +[Term] +id: GO:0032493 +name: response to bacterial lipoprotein +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222] +is_a: GO:0002237 ! response to molecule of bacterial origin + +[Term] +id: GO:0032494 +name: response to peptidoglycan +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0032495 +name: response to muramyl dipeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:0032496 +name: response to lipopolysaccharide +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] +synonym: "response to endotoxin" BROAD [GOC:sl] +synonym: "response to LPS" EXACT [] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0032497 +name: detection of lipopolysaccharide +namespace: biological_process +def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797] +synonym: "detection of LPS" EXACT [] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032496 ! response to lipopolysaccharide + +[Term] +id: GO:0032498 +name: detection of muramyl dipeptide +namespace: biological_process +def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797] +is_a: GO:0032495 ! response to muramyl dipeptide +is_a: GO:0032499 ! detection of peptidoglycan + +[Term] +id: GO:0032499 +name: detection of peptidoglycan +namespace: biological_process +def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032494 ! response to peptidoglycan + +[Term] +id: GO:0032500 +name: muramyl dipeptide binding +namespace: molecular_function +def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] +is_a: GO:0042277 ! peptide binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0032501 +name: multicellular organismal process +namespace: biological_process +alt_id: GO:0044707 +alt_id: GO:0050874 +def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "organismal physiological process" EXACT [] +synonym: "single-multicellular organism process" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0032502 +name: developmental process +namespace: biological_process +alt_id: GO:0044767 +def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] +subset: goslim_agr +subset: goslim_aspergillus +subset: goslim_flybase_ribbon +subset: goslim_pir +synonym: "development" NARROW [] +synonym: "single-organism developmental process" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0032504 +name: multicellular organism reproduction +namespace: biological_process +def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] +subset: goslim_drosophila +is_a: GO:0000003 ! reproduction +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0032505 +name: reproduction of a single-celled organism +namespace: biological_process +def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] +is_a: GO:0000003 ! reproduction + +[Term] +id: GO:0032506 +name: cytokinetic process +namespace: biological_process +def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000910 ! cytokinesis + +[Term] +id: GO:0032507 +name: maintenance of protein location in cell +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] +synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] +is_a: GO:0045185 ! maintenance of protein location +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0034613 ! cellular protein localization + +[Term] +id: GO:0032508 +name: DNA duplex unwinding +namespace: biological_process +def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] +comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. +synonym: "DNA unwinding" EXACT [] +synonym: "duplex DNA melting" EXACT [] +is_a: GO:0032392 ! DNA geometric change + +[Term] +id: GO:0032509 +name: endosome transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome transport via MVB sorting pathway" EXACT [] +is_a: GO:0016197 ! endosomal transport +is_a: GO:0071985 ! multivesicular body sorting pathway + +[Term] +id: GO:0032510 +name: endosome to lysosome transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT [] +is_a: GO:0008333 ! endosome to lysosome transport +is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway + +[Term] +id: GO:0032511 +name: late endosome to vacuole transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] +synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] +is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway +is_a: GO:0045324 ! late endosome to vacuole transport + +[Term] +id: GO:0032515 +name: negative regulation of phosphoprotein phosphatase activity +namespace: biological_process +alt_id: GO:0032513 +alt_id: GO:0034048 +def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah] +synonym: "down regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] +synonym: "down regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "down regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "down regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "down regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "down regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "down-regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "down-regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "downregulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] +synonym: "downregulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "downregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "downregulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "downregulation of protein phosphatase type 2A activity" NARROW [] +synonym: "downregulation of protein phosphatase type 2B activity" NARROW [] +synonym: "inhibition of calcineurin activity" NARROW [GOC:dph, GOC:rl] +synonym: "inhibition of phosphoprotein phosphatase activity" NARROW [] +synonym: "inhibition of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "inhibition of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "inhibition of protein phosphatase type 2A activity" NARROW [] +synonym: "inhibition of protein phosphatase type 2B activity" NARROW [] +synonym: "negative regulation of calcineurin activity" NARROW [] +synonym: "negative regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "negative regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "negative regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +is_a: GO:0010923 ! negative regulation of phosphatase activity +is_a: GO:0035308 ! negative regulation of protein dephosphorylation +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0032516 +name: positive regulation of phosphoprotein phosphatase activity +namespace: biological_process +alt_id: GO:0032514 +alt_id: GO:0034049 +def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah] +synonym: "activation of calcineurin activity" NARROW [GOC:dph, GOC:rl] +synonym: "activation of phosphoprotein phosphatase activity" NARROW [] +synonym: "activation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "activation of protein phosphatase type 2A activity" NARROW [] +synonym: "activation of protein phosphatase type 2B activity" NARROW [] +synonym: "calcineurin activation" NARROW [] +synonym: "positive regulation of calcineurin activity" NARROW [] +synonym: "positive regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "positive regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "positive regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "positive regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "stimulation of phosphoprotein phosphatase activity" NARROW [] +synonym: "stimulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "stimulation of protein phosphatase type 2A activity" NARROW [] +synonym: "stimulation of protein phosphatase type 2B activity" NARROW [] +synonym: "up regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] +synonym: "up regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "up regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "up regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "up regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "up regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "up-regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "up-regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "up-regulation of protein phosphatase type 2B activity" NARROW [] +synonym: "upregulation of phosphoprotein phosphatase activity" EXACT [] +synonym: "upregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "upregulation of protein phosphatase type 2A activity" NARROW [] +synonym: "upregulation of protein phosphatase type 2B activity" NARROW [] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:0035307 ! positive regulation of protein dephosphorylation +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0032517 +name: SOD1-calcineurin complex +namespace: cellular_component +def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0032523 +name: silicon efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] +synonym: "silicon efflux transporter activity" EXACT [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0032524 +name: obsolete nutrient export +namespace: biological_process +def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah] +comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. +synonym: "nutrient export" EXACT [] +is_obsolete: true +consider: GO:0006810 + +[Term] +id: GO:0032525 +name: somite rostral/caudal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776] +synonym: "somite rostrocaudal axis specification" EXACT [] +synonym: "somite rostrocaudal polarity" RELATED [] +is_a: GO:0000578 ! embryonic axis specification +is_a: GO:0009948 ! anterior/posterior axis specification +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0032526 +name: response to retinoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] +synonym: "response to vitamin A acid" EXACT [] +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0032527 +name: protein exit from endoplasmic reticulum +namespace: biological_process +def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb] +synonym: "protein exit from ER" EXACT [] +synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "protein export from ER" EXACT [GOC:mah] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0032528 +name: microvillus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] +synonym: "microvillus organisation" EXACT [GOC:mah] +synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0032529 +name: follicle cell microvillus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] +synonym: "follicle cell microvillus organisation" EXACT [GOC:mah] +synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0032528 ! microvillus organization + +[Term] +id: GO:0032530 +name: regulation of microvillus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] +synonym: "regulation of microvillus organisation" EXACT [GOC:mah] +synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: regulates GO:0032528 ! microvillus organization + +[Term] +id: GO:0032531 +name: regulation of follicle cell microvillus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] +synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah] +synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +relationship: regulates GO:0032529 ! follicle cell microvillus organization + +[Term] +id: GO:0032532 +name: regulation of microvillus length +namespace: biological_process +def: "A process that modulates the length of a microvillus." [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +is_a: GO:0032536 ! regulation of cell projection size + +[Term] +id: GO:0032533 +name: regulation of follicle cell microvillus length +namespace: biological_process +def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500] +is_a: GO:0008361 ! regulation of cell size +is_a: GO:0032531 ! regulation of follicle cell microvillus organization +is_a: GO:0032532 ! regulation of microvillus length + +[Term] +id: GO:0032534 +name: regulation of microvillus assembly +namespace: biological_process +def: "A process that modulates the formation of a microvillus." [GOC:mah] +synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] +is_a: GO:0032530 ! regulation of microvillus organization +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0030033 ! microvillus assembly + +[Term] +id: GO:0032535 +name: regulation of cellular component size +namespace: biological_process +def: "A process that modulates the size of a cellular component." [GOC:mah] +is_a: GO:0016043 ! cellular component organization +is_a: GO:0090066 ! regulation of anatomical structure size + +[Term] +id: GO:0032536 +name: regulation of cell projection size +namespace: biological_process +def: "A process that modulates the size of a cell projection." [GOC:mah] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0032537 +name: host-seeking behavior +namespace: biological_process +def: "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, GOC:pr, PMID:11931033] +synonym: "host-seeking behaviour" EXACT [] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0032538 +name: regulation of host-seeking behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "regulation of host-seeking behaviour" EXACT [] +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032539 +name: negative regulation of host-seeking behavior +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "down regulation of host-seeking behavior" EXACT [] +synonym: "down-regulation of host-seeking behavior" EXACT [] +synonym: "downregulation of host-seeking behavior" EXACT [] +synonym: "inhibition of host-seeking behavior" NARROW [] +synonym: "negative regulation of host-seeking behaviour" EXACT [] +is_a: GO:0032538 ! regulation of host-seeking behavior +is_a: GO:0048521 ! negative regulation of behavior +relationship: negatively_regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032540 +name: positive regulation of host-seeking behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] +synonym: "activation of host-seeking behavior" NARROW [] +synonym: "positive regulation of host-seeking behaviour" EXACT [] +synonym: "stimulation of host-seeking behavior" NARROW [] +synonym: "up regulation of host-seeking behavior" EXACT [] +synonym: "up-regulation of host-seeking behavior" EXACT [] +synonym: "upregulation of host-seeking behavior" EXACT [] +is_a: GO:0032538 ! regulation of host-seeking behavior +is_a: GO:0048520 ! positive regulation of behavior +relationship: positively_regulates GO:0032537 ! host-seeking behavior + +[Term] +id: GO:0032541 +name: cortical endoplasmic reticulum +namespace: cellular_component +def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] +comment: The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860) +synonym: "cortical ER" EXACT [] +synonym: "ER-PM peripheral junction" BROAD [GOC:ans, PMID:21062895] +synonym: "peripheral endoplasmic reticulum" RELATED [] +synonym: "peripheral ER" RELATED [] +is_a: GO:0071782 ! endoplasmic reticulum tubular network +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0032542 +name: sulfiredoxin activity +namespace: molecular_function +def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934] +synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] +synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] +synonym: "Srx1" RELATED [EC:1.8.98.2] +synonym: "sulphiredoxin activity" EXACT [] +xref: EC:1.8.98.2 +xref: MetaCyc:1.8.98.2-RXN +xref: RHEA:17545 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0032543 +name: mitochondrial translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] +subset: goslim_yeast +synonym: "mitochondrial protein anabolism" EXACT [] +synonym: "mitochondrial protein biosynthesis" EXACT [] +synonym: "mitochondrial protein formation" EXACT [] +synonym: "mitochondrial protein synthesis" EXACT [] +synonym: "mitochondrial protein translation" EXACT [] +is_a: GO:0006412 ! translation +relationship: part_of GO:0140053 ! mitochondrial gene expression + +[Term] +id: GO:0032544 +name: plastid translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] +synonym: "plastid protein anabolism" EXACT [] +synonym: "plastid protein biosynthesis" EXACT [] +synonym: "plastid protein formation" EXACT [] +synonym: "plastid protein synthesis" EXACT [] +synonym: "plastid protein translation" EXACT [] +is_a: GO:0006412 ! translation +is_a: GO:0009657 ! plastid organization + +[Term] +id: GO:0032545 +name: CURI complex +namespace: cellular_component +def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p." [PMID:17452446] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032546 +name: deoxyribonucleoside binding +namespace: molecular_function +def: "Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0032547 +name: purine deoxyribonucleoside binding +namespace: molecular_function +def: "Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] +is_a: GO:0001883 ! purine nucleoside binding +is_a: GO:0032546 ! deoxyribonucleoside binding + +[Term] +id: GO:0032548 +name: pyrimidine deoxyribonucleoside binding +namespace: molecular_function +def: "Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] +is_a: GO:0001884 ! pyrimidine nucleoside binding +is_a: GO:0032546 ! deoxyribonucleoside binding + +[Term] +id: GO:0032549 +name: ribonucleoside binding +namespace: molecular_function +def: "Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] +is_a: GO:0001882 ! nucleoside binding + +[Term] +id: GO:0032550 +name: purine ribonucleoside binding +namespace: molecular_function +def: "Binding to a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] +is_a: GO:0001883 ! purine nucleoside binding +is_a: GO:0032549 ! ribonucleoside binding + +[Term] +id: GO:0032551 +name: pyrimidine ribonucleoside binding +namespace: molecular_function +def: "Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] +is_a: GO:0001884 ! pyrimidine nucleoside binding +is_a: GO:0032549 ! ribonucleoside binding + +[Term] +id: GO:0032552 +name: deoxyribonucleotide binding +namespace: molecular_function +def: "Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0032553 +name: ribonucleotide binding +namespace: molecular_function +def: "Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0032554 +name: purine deoxyribonucleotide binding +namespace: molecular_function +def: "Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +is_a: GO:0017076 ! purine nucleotide binding +is_a: GO:0032552 ! deoxyribonucleotide binding + +[Term] +id: GO:0032555 +name: purine ribonucleotide binding +namespace: molecular_function +def: "Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +is_a: GO:0017076 ! purine nucleotide binding +is_a: GO:0032553 ! ribonucleotide binding + +[Term] +id: GO:0032556 +name: pyrimidine deoxyribonucleotide binding +namespace: molecular_function +def: "Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +is_a: GO:0019103 ! pyrimidine nucleotide binding +is_a: GO:0032552 ! deoxyribonucleotide binding + +[Term] +id: GO:0032557 +name: pyrimidine ribonucleotide binding +namespace: molecular_function +def: "Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +is_a: GO:0019103 ! pyrimidine nucleotide binding +is_a: GO:0032553 ! ribonucleotide binding + +[Term] +id: GO:0032558 +name: adenyl deoxyribonucleotide binding +namespace: molecular_function +def: "Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0032554 ! purine deoxyribonucleotide binding + +[Term] +id: GO:0032559 +name: adenyl ribonucleotide binding +namespace: molecular_function +def: "Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +is_a: GO:0030554 ! adenyl nucleotide binding +is_a: GO:0032555 ! purine ribonucleotide binding + +[Term] +id: GO:0032560 +name: guanyl deoxyribonucleotide binding +namespace: molecular_function +def: "Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] +is_a: GO:0019001 ! guanyl nucleotide binding +is_a: GO:0032554 ! purine deoxyribonucleotide binding + +[Term] +id: GO:0032561 +name: guanyl ribonucleotide binding +namespace: molecular_function +def: "Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] +is_a: GO:0019001 ! guanyl nucleotide binding +is_a: GO:0032555 ! purine ribonucleotide binding + +[Term] +id: GO:0032562 +name: dAMP binding +namespace: molecular_function +def: "Binding to dAMP, deoxyadenosine monophosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032563 +name: dADP binding +namespace: molecular_function +def: "Binding to dADP, deoxyadenosine diphosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032564 +name: dATP binding +namespace: molecular_function +def: "Binding to dATP, deoxyadenosine triphosphate." [GOC:mah] +is_a: GO:0032558 ! adenyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032565 +name: dGMP binding +namespace: molecular_function +def: "Binding to dGMP, deoxyguanosine monophosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032566 +name: dGDP binding +namespace: molecular_function +def: "Binding to dGDP, deoxyguanosine diphosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032567 +name: dGTP binding +namespace: molecular_function +def: "Binding to dGTP, deoxyguanosine triphosphate." [GOC:mah] +is_a: GO:0032560 ! guanyl deoxyribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0032570 +name: response to progesterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] +synonym: "response to progesterone stimulus" EXACT [GOC:dos] +is_a: GO:0048545 ! response to steroid hormone +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0032571 +name: response to vitamin K +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl] +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0032572 +name: response to menaquinone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl] +synonym: "response to menatetrenone" EXACT [] +synonym: "response to vitamin K2" EXACT [] +is_a: GO:0032571 ! response to vitamin K + +[Term] +id: GO:0032573 +name: response to phylloquinone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] +synonym: "response to vitamin K1" EXACT [] +is_a: GO:0032571 ! response to vitamin K + +[Term] +id: GO:0032574 +name: 5'-3' RNA helicase activity +namespace: molecular_function +alt_id: GO:0032575 +def: "Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:jp] +synonym: "5' to 3' RNA helicase activity" EXACT [] +synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] +synonym: "ATP-dependent 5'-3' RNA helicase activity" EXACT [] +xref: Reactome:R-HSA-9682695 "nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template" +xref: Reactome:R-HSA-9694265 "nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template" +is_a: GO:0003724 ! RNA helicase activity + +[Term] +id: GO:0032576 +name: O-linoleoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0032577 +name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] +synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] +is_a: GO:0032576 ! O-linoleoyltransferase activity + +[Term] +id: GO:0032578 +name: aleurone grain membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0033095 ! aleurone grain + +[Term] +id: GO:0032579 +name: apical lamina of hyaline layer +namespace: cellular_component +def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0033166 ! hyaline layer + +[Term] +id: GO:0032580 +name: Golgi cisterna membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] +synonym: "Golgi stack membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0031985 ! Golgi cisterna + +[Term] +id: GO:0032581 +name: ER-dependent peroxisome organization +namespace: biological_process +def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399] +synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah] +synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah] +synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah] +is_a: GO:0007031 ! peroxisome organization + +[Term] +id: GO:0032584 +name: growth cone membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:0032585 +name: multivesicular body membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] +synonym: "multivesicular endosome membrane" EXACT [] +synonym: "MVB membrane" EXACT [] +synonym: "MVE membrane" EXACT [] +is_a: GO:0031902 ! late endosome membrane +relationship: part_of GO:0005771 ! multivesicular body + +[Term] +id: GO:0032586 +name: protein storage vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] +is_a: GO:0009705 ! plant-type vacuole membrane +relationship: part_of GO:0000326 ! protein storage vacuole + +[Term] +id: GO:0032587 +name: ruffle membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] +synonym: "membrane ruffle" RELATED [] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0001726 ! ruffle + +[Term] +id: GO:0032588 +name: trans-Golgi network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] +synonym: "Golgi trans face membrane" RELATED [] +synonym: "trans Golgi network membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0005802 ! trans-Golgi network + +[Term] +id: GO:0032589 +name: neuron projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0031256 ! leading edge membrane +relationship: part_of GO:0043005 ! neuron projection + +[Term] +id: GO:0032590 +name: dendrite membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] +is_a: GO:0032589 ! neuron projection membrane +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0032591 +name: dendritic spine membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] +is_a: GO:0032589 ! neuron projection membrane +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0032590 ! dendrite membrane +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0032592 +name: integral component of mitochondrial membrane +namespace: cellular_component +def: "The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to mitochondrial membrane" NARROW [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0098573 ! intrinsic component of mitochondrial membrane + +[Term] +id: GO:0032593 +name: insulin-responsive compartment +namespace: cellular_component +def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] +synonym: "GLUT4 storage compartment" EXACT [] +synonym: "GSC" RELATED [] +synonym: "IRC" RELATED [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0032594 +name: protein transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] +synonym: "protein translocation within membrane" EXACT [] +synonym: "receptor translocation within membrane" NARROW [] +synonym: "receptor transport within lipid bilayer" NARROW [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0032595 +name: B cell receptor transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah] +synonym: "B cell receptor translocation within membrane" EXACT [] +synonym: "BCR translocation within membrane" EXACT [] +synonym: "BCR transport within lipid bilayer" EXACT [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0032596 +name: protein transport into membrane raft +namespace: biological_process +def: "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] +synonym: "protein translocation into membrane raft" EXACT [] +synonym: "protein transport into lipid raft" EXACT [] +synonym: "receptor translocation into membrane raft" NARROW [] +synonym: "receptor transport into membrane raft" NARROW [] +is_a: GO:0032594 ! protein transport within lipid bilayer +is_a: GO:0090150 ! establishment of protein localization to membrane +is_a: GO:1903044 ! protein localization to membrane raft + +[Term] +id: GO:0032597 +name: B cell receptor transport into membrane raft +namespace: biological_process +def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah] +synonym: "B cell receptor translocation into membrane raft" EXACT [] +synonym: "B cell receptor transport into lipid raft" EXACT [] +synonym: "BCR translocation into membrane raft" EXACT [] +synonym: "BCR transport into membrane raft" EXACT [] +is_a: GO:0032595 ! B cell receptor transport within lipid bilayer +is_a: GO:0032596 ! protein transport into membrane raft + +[Term] +id: GO:0032598 +name: B cell receptor transport into immunological synapse +namespace: biological_process +def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah] +synonym: "B cell receptor translocation into immunological synapse" EXACT [] +synonym: "BCR translocation into immunological synapse" EXACT [] +synonym: "BCR transport into immunological synapse" EXACT [] +is_a: GO:0032597 ! B cell receptor transport into membrane raft + +[Term] +id: GO:0032599 +name: protein transport out of membrane raft +namespace: biological_process +def: "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] +synonym: "protein translocation out of membrane raft" EXACT [] +synonym: "protein transport out of lipid raft" EXACT [] +synonym: "receptor translocation out of membrane raft" NARROW [] +synonym: "receptor transport out of membrane raft" NARROW [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0032600 +name: chemokine receptor transport out of membrane raft +namespace: biological_process +def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah] +synonym: "chemokine receptor translocation out of membrane raft" EXACT [] +synonym: "chemokine receptor transport out of lipid raft" EXACT [] +is_a: GO:0032599 ! protein transport out of membrane raft +is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer + +[Term] +id: GO:0032601 +name: connective tissue growth factor production +namespace: biological_process +def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "CCN2 production" EXACT [] +synonym: "CTGF production" EXACT [] +synonym: "Fisp12 production" EXACT [] +synonym: "Hcs24 production" EXACT [] +synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "IGFBP8 production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032602 +name: chemokine production +namespace: biological_process +alt_id: GO:0042033 +alt_id: GO:0050755 +alt_id: GO:0090195 +def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, ISBN:0198506732, PMID:12183377, Wikipedia:Chemokine] +subset: gocheck_do_not_annotate +synonym: "chemokine anabolism" EXACT [] +synonym: "chemokine biosynthesis" EXACT [] +synonym: "chemokine biosynthetic process" NARROW [] +synonym: "chemokine formation" EXACT [] +synonym: "chemokine metabolic process" NARROW [] +synonym: "chemokine secretion" NARROW [] +synonym: "chemokine synthesis" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032603 +name: fractalkine production +namespace: biological_process +alt_id: GO:0050751 +alt_id: GO:0050754 +alt_id: GO:0050756 +def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:12729461] +subset: gocheck_do_not_annotate +synonym: "ABCD-3 production" EXACT [] +synonym: "CX3CL1 production" EXACT [] +synonym: "fractalkine biosynthetic process" NARROW [] +synonym: "fractalkine metabolic process" NARROW [] +synonym: "neurotactin production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0032604 +name: granulocyte macrophage colony-stimulating factor production +namespace: biological_process +alt_id: GO:0042253 +def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, ISBN:0198506732] +subset: gocheck_do_not_annotate +synonym: "GM-CSF production" EXACT [GOC:vk] +synonym: "granulocyte macrophage colony stimulating factor production" EXACT [] +synonym: "granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +is_a: GO:0001816 ! cytokine production +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:0032605 +name: hepatocyte growth factor production +namespace: biological_process +alt_id: GO:0048175 +def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:1838014] +subset: gocheck_do_not_annotate +synonym: "hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "HGF production" EXACT [] +synonym: "scatter factor production" EXACT [] +is_a: GO:0001816 ! cytokine production +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:0032606 +name: type I interferon production +namespace: biological_process +alt_id: GO:0045351 +alt_id: GO:0072641 +def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "interferon type I production" EXACT [] +synonym: "type I IFN production" EXACT [GOC:mah] +synonym: "type I interferon biosynthetic process" NARROW [] +synonym: "type I interferon secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032607 +name: interferon-alpha production +namespace: biological_process +alt_id: GO:0045349 +alt_id: GO:0072642 +def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-alpha production" EXACT [GOC:mah] +synonym: "IFNA production" EXACT [GOC:mah] +synonym: "interferon-alpha biosynthetic process" NARROW [] +synonym: "interferon-alpha secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0032608 +name: interferon-beta production +namespace: biological_process +alt_id: GO:0035546 +alt_id: GO:0045350 +def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-beta production" EXACT [] +synonym: "IFNB production" EXACT [GOC:mah] +synonym: "interferon-beta biosynthetic process" NARROW [] +synonym: "interferon-beta secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0032609 +name: interferon-gamma production +namespace: biological_process +alt_id: GO:0042095 +alt_id: GO:0072643 +def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] +subset: gocheck_do_not_annotate +synonym: "IFNG production" EXACT [GOC:mah] +synonym: "interferon-gamma biosynthetic process" NARROW [] +synonym: "interferon-gamma secretion" NARROW [] +synonym: "type II IFN production" BROAD [GOC:mah] +synonym: "type II interferon production" BROAD [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032610 +name: interleukin-1 alpha production +namespace: biological_process +alt_id: GO:0050703 +alt_id: GO:0050719 +def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-1 alpha production" EXACT [] +synonym: "interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "interleukin-1 alpha secretion" NARROW [] +is_a: GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032611 +name: interleukin-1 beta production +namespace: biological_process +alt_id: GO:0050702 +alt_id: GO:0050720 +def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-1 beta production" EXACT [] +synonym: "interleukin-1 beta biosynthetic process" NARROW [] +synonym: "interleukin-1 beta secretion" NARROW [] +is_a: GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032612 +name: interleukin-1 production +namespace: biological_process +alt_id: GO:0042222 +alt_id: GO:0050701 +def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-1 production" EXACT [] +synonym: "interleukin-1 biosynthetic process" NARROW [] +synonym: "interleukin-1 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032613 +name: interleukin-10 production +namespace: biological_process +alt_id: GO:0042091 +alt_id: GO:0072608 +def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-10 production" EXACT [] +synonym: "interleukin-10 biosynthetic process" NARROW [] +synonym: "interleukin-10 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032614 +name: interleukin-11 production +namespace: biological_process +alt_id: GO:0042230 +alt_id: GO:0072609 +def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-11 production" EXACT [] +synonym: "interleukin-11 biosynthetic process" NARROW [] +synonym: "interleukin-11 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032615 +name: interleukin-12 production +namespace: biological_process +alt_id: GO:0042090 +alt_id: GO:0072610 +def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "CLMF production" NARROW [GOC:BHF] +synonym: "IL-12 production" EXACT [] +synonym: "interleukin-12 biosynthetic process" NARROW [] +synonym: "interleukin-12 secretion" NARROW [] +synonym: "NKSF production" NARROW [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032616 +name: interleukin-13 production +namespace: biological_process +alt_id: GO:0042231 +alt_id: GO:0072611 +def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-13 production" EXACT [] +synonym: "interleukin-13 biosynthetic process" NARROW [] +synonym: "interleukin-13 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032617 +name: obsolete interleukin-14 production +namespace: biological_process +alt_id: GO:0042232 +alt_id: GO:0072612 +def: "OBSOLETE. The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +subset: gocheck_do_not_annotate +synonym: "IL-14 production" EXACT [] +synonym: "interleukin-14 biosynthetic process" NARROW [] +synonym: "interleukin-14 secretion" NARROW [] +is_obsolete: true + +[Term] +id: GO:0032618 +name: interleukin-15 production +namespace: biological_process +alt_id: GO:0042233 +alt_id: GO:0072613 +def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-15 production" EXACT [] +synonym: "interleukin-15 biosynthetic process" NARROW [] +synonym: "interleukin-15 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032619 +name: interleukin-16 production +namespace: biological_process +alt_id: GO:0042234 +alt_id: GO:0072614 +def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-16 production" EXACT [] +synonym: "interleukin-16 biosynthetic process" NARROW [] +synonym: "interleukin-16 secretion" NARROW [] +synonym: "LCF production" NARROW [GOC:BHF] +synonym: "pro-interleukin-16 production" EXACT [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032620 +name: interleukin-17 production +namespace: biological_process +alt_id: GO:0042235 +alt_id: GO:0072615 +def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, Wikipedia:Interleukin_17] +subset: gocheck_do_not_annotate +synonym: "CTLA-8 production" EXACT [GOC:BHF] +synonym: "Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:BHF] +synonym: "IL-17 production" EXACT [] +synonym: "interleukin-17 biosynthetic process" NARROW [] +synonym: "interleukin-17 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032621 +name: interleukin-18 production +namespace: biological_process +alt_id: GO:0042241 +alt_id: GO:0072616 +def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IGIF production" EXACT [GOC:BHF] +synonym: "IL-18 production" EXACT [] +synonym: "IL1F4 production" NARROW [GOC:BHF] +synonym: "interleukin-18 biosynthetic process" NARROW [] +synonym: "interleukin-18 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032622 +name: interleukin-19 production +namespace: biological_process +alt_id: GO:0042236 +alt_id: GO:0072617 +def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-19 production" EXACT [] +synonym: "IL-19 secretion" NARROW [GOC:BHF] +synonym: "interleukin-19 biosynthetic process" NARROW [] +synonym: "interleukin-19 secretion" NARROW [] +synonym: "ZMDA1 secretion" NARROW [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032623 +name: interleukin-2 production +namespace: biological_process +alt_id: GO:0042094 +alt_id: GO:0070970 +def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-2 production" EXACT [] +synonym: "interleukin-2 biosynthetic process" NARROW [] +synonym: "interleukin-2 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032624 +name: interleukin-20 production +namespace: biological_process +alt_id: GO:0042237 +alt_id: GO:0072618 +def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-20 production" EXACT [] +synonym: "interleukin-20 biosynthetic process" NARROW [] +synonym: "interleukin-20 secretion" NARROW [] +synonym: "ZCYTO10 production" EXACT [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032625 +name: interleukin-21 production +namespace: biological_process +alt_id: GO:0042238 +alt_id: GO:0072619 +def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-21 production" EXACT [] +synonym: "interleukin-21 biosynthetic process" NARROW [] +synonym: "interleukin-21 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032626 +name: interleukin-22 production +namespace: biological_process +alt_id: GO:0042239 +alt_id: GO:0072620 +def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-22 production" EXACT [] +synonym: "IL22 production" EXACT [GOC:BHF] +synonym: "ILTIF production" EXACT [GOC:BHF] +synonym: "interleukin-22 biosynthetic process" NARROW [] +synonym: "interleukin-22 secretion" NARROW [] +synonym: "ZCYTO18 production" NARROW [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032627 +name: interleukin-23 production +namespace: biological_process +alt_id: GO:0042240 +alt_id: GO:0072621 +def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-23 production" EXACT [] +synonym: "interleukin-23 biosynthetic process" NARROW [] +synonym: "interleukin-23 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032628 +name: interleukin-24 production +namespace: biological_process +alt_id: GO:0045524 +alt_id: GO:0072622 +def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-24 production" EXACT [] +synonym: "interleukin-24 biosynthetic process" NARROW [] +synonym: "interleukin-24 secretion" NARROW [] +synonym: "MDA7 production" NARROW [GOC:BHF] +synonym: "ST16 production" NARROW [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032629 +name: interleukin-25 production +namespace: biological_process +alt_id: GO:0045525 +alt_id: GO:0072623 +def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-25 production" EXACT [] +synonym: "IL-25 secretion" NARROW [GOC:BHF] +synonym: "IL17E secretion" NARROW [GOC:BHF] +synonym: "interleukin-25 anabolism" NARROW [] +synonym: "interleukin-25 biosynthesis" NARROW [] +synonym: "interleukin-25 biosynthetic process" NARROW [] +synonym: "interleukin-25 formation" NARROW [] +synonym: "interleukin-25 secretion" NARROW [] +synonym: "interleukin-25 synthesis" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032630 +name: interleukin-26 production +namespace: biological_process +alt_id: GO:0045526 +alt_id: GO:0072624 +def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "AK155 secretion" NARROW [GOC:BHF] +synonym: "IL-26 production" EXACT [] +synonym: "interleukin-26 anabolism" NARROW [] +synonym: "interleukin-26 biosynthesis" NARROW [] +synonym: "interleukin-26 biosynthetic process" NARROW [] +synonym: "interleukin-26 formation" NARROW [] +synonym: "interleukin-26 secretion" NARROW [] +synonym: "interleukin-26 synthesis" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032631 +name: interleukin-27 production +namespace: biological_process +alt_id: GO:0045527 +alt_id: GO:0072625 +def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-27 production" EXACT [] +synonym: "interleukin-27 biosynthetic process" NARROW [] +synonym: "interleukin-27 formation" NARROW [] +synonym: "interleukin-27 secretion" NARROW [] +synonym: "interleukin-27 synthesis" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032632 +name: interleukin-3 production +namespace: biological_process +alt_id: GO:0042223 +alt_id: GO:0072601 +def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-3 production" EXACT [] +synonym: "interleukin-3 biosynthetic process" NARROW [] +synonym: "interleukin-3 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032633 +name: interleukin-4 production +namespace: biological_process +alt_id: GO:0042097 +alt_id: GO:0042224 +alt_id: GO:0072602 +def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-4 production" EXACT [] +synonym: "interleukin-4 biosynthetic process" NARROW [] +synonym: "interleukin-4 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032634 +name: interleukin-5 production +namespace: biological_process +alt_id: GO:0042225 +alt_id: GO:0072603 +def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-5 production" EXACT [] +synonym: "interleukin-5 biosynthetic process" NARROW [] +synonym: "interleukin-5 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032635 +name: interleukin-6 production +namespace: biological_process +alt_id: GO:0042226 +alt_id: GO:0072604 +def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-6 production" EXACT [] +synonym: "interleukin-6 biosynthetic process" NARROW [] +synonym: "interleukin-6 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032636 +name: interleukin-7 production +namespace: biological_process +alt_id: GO:0042227 +alt_id: GO:0072605 +def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-7 production" EXACT [] +synonym: "interleukin-7 biosynthetic process" NARROW [] +synonym: "interleukin-7 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032637 +name: interleukin-8 production +namespace: biological_process +alt_id: GO:0042228 +alt_id: GO:0072606 +def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-8 production" EXACT [] +synonym: "interleukin-8 biosynthetic process" NARROW [] +synonym: "interleukin-8 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032638 +name: interleukin-9 production +namespace: biological_process +alt_id: GO:0042229 +alt_id: GO:0072607 +def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-9 production" EXACT [] +synonym: "interleukin-9 biosynthetic process" NARROW [] +synonym: "interleukin-9 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0032639 +name: TRAIL production +namespace: biological_process +alt_id: GO:0045553 +def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9311998] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "TRAIL biosynthetic process" NARROW [] +is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:0032640 +name: tumor necrosis factor production +namespace: biological_process +alt_id: GO:0042533 +alt_id: GO:1990774 +def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:mah, PMID:10891884, PMID:15560120] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "cachectin production" EXACT [] +synonym: "TNF alpha biosynthesis" NARROW [] +synonym: "TNF biosynthesis" NARROW [] +synonym: "TNF biosynthetic process" NARROW [] +synonym: "TNF production" EXACT [] +synonym: "TNF-alpha biosynthesis" NARROW [] +synonym: "TNF-alpha biosynthetic process" NARROW [] +synonym: "TNF-alpha production" RELATED [] +synonym: "Tnfa production" RELATED [] +synonym: "tumor necrosis factor anabolism" NARROW [] +synonym: "tumor necrosis factor biosynthesis" NARROW [] +synonym: "tumor necrosis factor biosynthetic process" NARROW [] +synonym: "tumor necrosis factor formation" NARROW [] +synonym: "tumor necrosis factor secretion" NARROW [] +synonym: "tumor necrosis factor synthesis" NARROW [] +synonym: "tumor necrosis factor-alpha production" RELATED [] +is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:0032641 +name: lymphotoxin A production +namespace: biological_process +alt_id: GO:0042109 +def: "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "LTA production" EXACT [] +synonym: "lymphotoxin A biosynthetic process" NARROW [] +synonym: "lymphotoxin A formation" RELATED [] +synonym: "lymphotoxin A synthesis" NARROW [] +synonym: "lymphotoxin-alpha production" EXACT [] +synonym: "TNF-B production" EXACT [] +synonym: "TNF-beta production" EXACT [] +synonym: "tumor necrosis factor-beta production" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:0032642 +name: regulation of chemokine production +namespace: biological_process +alt_id: GO:0045073 +alt_id: GO:0090196 +def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] +synonym: "regulation of chemokine biosynthetic process" NARROW [] +synonym: "regulation of chemokine secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032643 +name: regulation of connective tissue growth factor production +namespace: biological_process +alt_id: GO:0045420 +def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "regulation of CCN2 production" EXACT [] +synonym: "regulation of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "regulation of CTGF production" EXACT [] +synonym: "regulation of Fisp12 production" EXACT [] +synonym: "regulation of Hcs24 production" EXACT [] +synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "regulation of IGFBP8 production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032644 +name: regulation of fractalkine production +namespace: biological_process +alt_id: GO:0050752 +def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "regulation of CX3CL1 biosynthesis" NARROW [] +synonym: "regulation of CX3CL1 production" NARROW [] +synonym: "regulation of fractalkine biosynthetic process" NARROW [] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032645 +name: regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +alt_id: GO:0045423 +def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +synonym: "regulation of GM-CSF production" EXACT [GOC:vk] +synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT [] +synonym: "regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032646 +name: regulation of hepatocyte growth factor production +namespace: biological_process +alt_id: GO:0048176 +def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014] +synonym: "regulation of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "regulation of HGF production" EXACT [] +synonym: "regulation of scatter factor production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032647 +name: regulation of interferon-alpha production +namespace: biological_process +alt_id: GO:0045354 +alt_id: GO:1902739 +def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] +synonym: "regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "regulation of interferon-alpha secretion" NARROW [] +is_a: GO:0032479 ! regulation of type I interferon production +relationship: regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032648 +name: regulation of interferon-beta production +namespace: biological_process +alt_id: GO:0035547 +alt_id: GO:0045357 +def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] +synonym: "regulation of IFN-beta production" EXACT [] +synonym: "regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "regulation of interferon-beta secretion" NARROW [] +is_a: GO:0032479 ! regulation of type I interferon production +relationship: regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032649 +name: regulation of interferon-gamma production +namespace: biological_process +alt_id: GO:0045072 +alt_id: GO:1902713 +def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] +synonym: "regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "regulation of interferon-gamma secretion" NARROW [] +synonym: "regulation of type II interferon production" BROAD [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032650 +name: regulation of interleukin-1 alpha production +namespace: biological_process +alt_id: GO:0050705 +alt_id: GO:0050721 +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "regulation of IL-1 alpha production" EXACT [] +synonym: "regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 alpha secretion" NARROW [] +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032651 +name: regulation of interleukin-1 beta production +namespace: biological_process +alt_id: GO:0050706 +alt_id: GO:0050722 +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "regulation of IL-1 beta production" EXACT [] +synonym: "regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 beta secretion" NARROW [] +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032652 +name: regulation of interleukin-1 production +namespace: biological_process +alt_id: GO:0045360 +alt_id: GO:0050704 +def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "regulation of IL-1 production" EXACT [] +synonym: "regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-1 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032653 +name: regulation of interleukin-10 production +namespace: biological_process +alt_id: GO:0045074 +alt_id: GO:2001179 +def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "regulation of IL-10 production" EXACT [] +synonym: "regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-10 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032654 +name: regulation of interleukin-11 production +namespace: biological_process +alt_id: GO:0045363 +alt_id: GO:0150169 +def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137] +synonym: "regulation of IL-11 production" EXACT [] +synonym: "regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-11 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032655 +name: regulation of interleukin-12 production +namespace: biological_process +alt_id: GO:0045075 +alt_id: GO:2001182 +def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "regulation of CLMF production" RELATED [GOC:obol] +synonym: "regulation of IL-12 production" EXACT [] +synonym: "regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-12 secretion" NARROW [] +synonym: "regulation of NKSF production" RELATED [GOC:obol] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032656 +name: regulation of interleukin-13 production +namespace: biological_process +alt_id: GO:0045366 +alt_id: GO:2000665 +def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "regulation of IL-13 production" EXACT [] +synonym: "regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-13 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032657 +name: obsolete regulation of interleukin-14 production +namespace: biological_process +alt_id: GO:0045369 +def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "regulation of IL-14 production" EXACT [] +synonym: "regulation of interleukin-14 biosynthetic process" NARROW [] +is_obsolete: true + +[Term] +id: GO:0032658 +name: regulation of interleukin-15 production +namespace: biological_process +alt_id: GO:0045372 +def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "regulation of IL-15 production" EXACT [] +synonym: "regulation of interleukin-15 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032659 +name: regulation of interleukin-16 production +namespace: biological_process +alt_id: GO:0045375 +def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "regulation of IL-16 production" EXACT [] +synonym: "regulation of interleukin-16 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032660 +name: regulation of interleukin-17 production +namespace: biological_process +alt_id: GO:0045378 +alt_id: GO:1905076 +def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] +synonym: "regulation of CTLA-8 production" EXACT [GOC:TermGenie] +synonym: "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [] +synonym: "regulation of IL-17 production" EXACT [] +synonym: "regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-17 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032661 +name: regulation of interleukin-18 production +namespace: biological_process +alt_id: GO:0045381 +alt_id: GO:0150120 +def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316] +synonym: "regulation of IL-18 production" EXACT [] +synonym: "regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-18 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032662 +name: regulation of interleukin-19 production +namespace: biological_process +alt_id: GO:0045384 +def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "regulation of IL-19 production" EXACT [] +synonym: "regulation of interleukin-19 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032663 +name: regulation of interleukin-2 production +namespace: biological_process +alt_id: GO:0045076 +alt_id: GO:1900040 +def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "regulation of IL-2 production" EXACT [] +synonym: "regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-2 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032664 +name: regulation of interleukin-20 production +namespace: biological_process +alt_id: GO:0045387 +def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "regulation of IL-20 production" EXACT [] +synonym: "regulation of interleukin-20 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032665 +name: regulation of interleukin-21 production +namespace: biological_process +alt_id: GO:0045390 +def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "regulation of IL-21 production" EXACT [] +synonym: "regulation of interleukin-21 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032666 +name: regulation of interleukin-22 production +namespace: biological_process +alt_id: GO:0045393 +def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "regulation of IL-22 production" EXACT [] +synonym: "regulation of interleukin-22 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032667 +name: regulation of interleukin-23 production +namespace: biological_process +alt_id: GO:0045396 +def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "regulation of IL-23 biosynthetic process" EXACT [] +synonym: "regulation of IL-23 production" EXACT [] +synonym: "regulation of interleukin-23 anabolism" NARROW [] +synonym: "regulation of interleukin-23 biosynthesis" NARROW [] +synonym: "regulation of interleukin-23 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-23 formation" NARROW [] +synonym: "regulation of interleukin-23 synthesis" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032668 +name: regulation of interleukin-24 production +namespace: biological_process +alt_id: GO:0045528 +def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "regulation of IL-24 production" EXACT [] +synonym: "regulation of interleukin-24 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032669 +name: regulation of interleukin-25 production +namespace: biological_process +alt_id: GO:0045529 +alt_id: GO:0150148 +def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah, PMID:27901018] +synonym: "regulation of IL-25 production" EXACT [] +synonym: "regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-25 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032670 +name: regulation of interleukin-26 production +namespace: biological_process +alt_id: GO:0045530 +def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "regulation of IL-26 production" EXACT [] +synonym: "regulation of interleukin-26 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032671 +name: regulation of interleukin-27 production +namespace: biological_process +alt_id: GO:0045531 +def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "regulation of IL-27 production" EXACT [] +synonym: "regulation of interleukin-27 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-27 formation" NARROW [] +synonym: "regulation of interleukin-27 synthesis" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032672 +name: regulation of interleukin-3 production +namespace: biological_process +alt_id: GO:0045399 +def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "regulation of IL-3 production" EXACT [] +synonym: "regulation of interleukin-3 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032673 +name: regulation of interleukin-4 production +namespace: biological_process +alt_id: GO:0045402 +alt_id: GO:0150133 +def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] +synonym: "regulation of IL-4 production" EXACT [] +synonym: "regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-4 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032674 +name: regulation of interleukin-5 production +namespace: biological_process +alt_id: GO:0045405 +alt_id: GO:2000662 +def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "regulation of IL-5 production" EXACT [] +synonym: "regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-5 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032675 +name: regulation of interleukin-6 production +namespace: biological_process +alt_id: GO:0045408 +def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "regulation of IL-6 production" EXACT [] +synonym: "regulation of interleukin-6 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032676 +name: regulation of interleukin-7 production +namespace: biological_process +alt_id: GO:0045411 +alt_id: GO:0150112 +def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782] +synonym: "regulation of IL-7 production" EXACT [] +synonym: "regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-7 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032677 +name: regulation of interleukin-8 production +namespace: biological_process +alt_id: GO:0045414 +alt_id: GO:2000482 +def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "regulation of IL-8 production" EXACT [] +synonym: "regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-8 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032678 +name: regulation of interleukin-9 production +namespace: biological_process +alt_id: GO:0045417 +def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "regulation of IL-9 production" EXACT [] +synonym: "regulation of interleukin-9 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032679 +name: regulation of TRAIL production +namespace: biological_process +alt_id: GO:0045554 +def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah] +synonym: "regulation of TRAIL biosynthetic process" NARROW [] +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032680 +name: regulation of tumor necrosis factor production +namespace: biological_process +alt_id: GO:0042534 +alt_id: GO:1904467 +def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "regulation of cachectin production" EXACT [GOC:TermGenie] +synonym: "regulation of TNF production" EXACT [] +synonym: "regulation of TNF-alpha production" EXACT [] +synonym: "regulation of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "regulation of tumor necrosis factor secretion" NARROW [] +synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032681 +name: regulation of lymphotoxin A production +namespace: biological_process +alt_id: GO:0043016 +def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "regulation of LTA production" EXACT [] +synonym: "regulation of lymphotoxin A biosynthetic process" NARROW [] +synonym: "regulation of lymphotoxin-alpha production" EXACT [] +synonym: "regulation of TNF-beta production" EXACT [] +synonym: "regulation of tumor necrosis factor-beta production" EXACT [] +is_a: GO:0051246 ! regulation of protein metabolic process +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032682 +name: negative regulation of chemokine production +namespace: biological_process +alt_id: GO:0045079 +alt_id: GO:0090198 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah] +synonym: "down regulation of chemokine production" EXACT [] +synonym: "down-regulation of chemokine production" EXACT [] +synonym: "downregulation of chemokine production" EXACT [] +synonym: "inhibition of chemokine production" NARROW [] +synonym: "negative regulation of chemokine biosynthetic process" NARROW [] +synonym: "negative regulation of chemokine secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032642 ! regulation of chemokine production +relationship: negatively_regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032683 +name: negative regulation of connective tissue growth factor production +namespace: biological_process +alt_id: GO:0045421 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "down regulation of connective tissue growth factor production" EXACT [] +synonym: "down-regulation of connective tissue growth factor production" EXACT [] +synonym: "downregulation of connective tissue growth factor production" EXACT [] +synonym: "inhibition of connective tissue growth factor production" NARROW [] +synonym: "negative regulation of CCN2 production" EXACT [] +synonym: "negative regulation of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "negative regulation of CTGF production" EXACT [] +synonym: "negative regulation of Fisp12 production" EXACT [] +synonym: "negative regulation of Hcs24 production" EXACT [] +synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "negative regulation of IGFBP8 production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032643 ! regulation of connective tissue growth factor production +relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032684 +name: negative regulation of fractalkine production +namespace: biological_process +alt_id: GO:0050753 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "down regulation of fractalkine production" EXACT [] +synonym: "down-regulation of fractalkine production" EXACT [] +synonym: "downregulation of fractalkine production" EXACT [] +synonym: "inhibition of fractalkine production" NARROW [] +synonym: "negative regulation of CX3CL1 biosynthesis" NARROW [] +synonym: "negative regulation of CX3CL1 production" EXACT [] +synonym: "negative regulation of fractalkine biosynthetic process" NARROW [] +is_a: GO:0032644 ! regulation of fractalkine production +is_a: GO:0032682 ! negative regulation of chemokine production +relationship: negatively_regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032685 +name: negative regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +alt_id: GO:0045424 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW [] +synonym: "negative regulation of GM-CSF production" EXACT [GOC:vk] +synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT [] +synonym: "negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032686 +name: negative regulation of hepatocyte growth factor production +namespace: biological_process +alt_id: GO:0048178 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014] +synonym: "down regulation of hepatocyte growth factor production" EXACT [] +synonym: "down-regulation of hepatocyte growth factor production" EXACT [] +synonym: "downregulation of hepatocyte growth factor production" EXACT [] +synonym: "inhibition of hepatocyte growth factor production" NARROW [] +synonym: "negative regulation of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "negative regulation of HGF production" EXACT [] +synonym: "negative regulation of scatter factor production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032646 ! regulation of hepatocyte growth factor production +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032687 +name: negative regulation of interferon-alpha production +namespace: biological_process +alt_id: GO:0045355 +alt_id: GO:1902740 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] +synonym: "down regulation of interferon-alpha production" EXACT [] +synonym: "down-regulation of interferon-alpha production" EXACT [] +synonym: "downregulation of interferon-alpha production" EXACT [] +synonym: "inhibition of interferon-alpha production" NARROW [] +synonym: "negative regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-alpha secretion" NARROW [] +is_a: GO:0032480 ! negative regulation of type I interferon production +is_a: GO:0032647 ! regulation of interferon-alpha production +relationship: negatively_regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032688 +name: negative regulation of interferon-beta production +namespace: biological_process +alt_id: GO:0035548 +alt_id: GO:0045358 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] +synonym: "down regulation of interferon-beta production" EXACT [] +synonym: "down-regulation of interferon-beta production" EXACT [] +synonym: "downregulation of interferon-beta production" EXACT [] +synonym: "inhibition of interferon-beta production" NARROW [] +synonym: "negative regulation of IFN-beta production" EXACT [] +synonym: "negative regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-beta secretion" NARROW [] +is_a: GO:0032480 ! negative regulation of type I interferon production +is_a: GO:0032648 ! regulation of interferon-beta production +relationship: negatively_regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032689 +name: negative regulation of interferon-gamma production +namespace: biological_process +alt_id: GO:0045077 +alt_id: GO:1902714 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] +synonym: "down regulation of interferon-gamma production" EXACT [] +synonym: "down-regulation of interferon-gamma production" EXACT [] +synonym: "downregulation of interferon-gamma production" EXACT [] +synonym: "inhibition of interferon-gamma production" NARROW [] +synonym: "negative regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "negative regulation of interferon-gamma secretion" NARROW [] +synonym: "negative regulation of type II interferon production" BROAD [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032649 ! regulation of interferon-gamma production +relationship: negatively_regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032690 +name: negative regulation of interleukin-1 alpha production +namespace: biological_process +alt_id: GO:0050712 +alt_id: GO:0050723 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "down regulation of interleukin-1 alpha production" EXACT [] +synonym: "down-regulation of interleukin-1 alpha production" EXACT [] +synonym: "downregulation of interleukin-1 alpha production" EXACT [] +synonym: "inhibition of interleukin-1 alpha production" NARROW [] +synonym: "negative regulation of IL-1 alpha production" EXACT [] +synonym: "negative regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 alpha secretion" NARROW [] +is_a: GO:0032650 ! regulation of interleukin-1 alpha production +is_a: GO:0032692 ! negative regulation of interleukin-1 production +relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032691 +name: negative regulation of interleukin-1 beta production +namespace: biological_process +alt_id: GO:0050713 +alt_id: GO:0050724 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "down regulation of interleukin-1 beta production" EXACT [] +synonym: "down-regulation of interleukin-1 beta production" EXACT [] +synonym: "downregulation of interleukin-1 beta production" EXACT [] +synonym: "inhibition of interleukin-1 beta production" NARROW [] +synonym: "negative regulation of IL-1 beta production" EXACT [] +synonym: "negative regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 beta secretion" NARROW [] +is_a: GO:0032651 ! regulation of interleukin-1 beta production +is_a: GO:0032692 ! negative regulation of interleukin-1 production +relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032692 +name: negative regulation of interleukin-1 production +namespace: biological_process +alt_id: GO:0045361 +alt_id: GO:0050711 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "down regulation of interleukin-1 production" EXACT [] +synonym: "down-regulation of interleukin-1 production" EXACT [] +synonym: "downregulation of interleukin-1 production" EXACT [] +synonym: "inhibition of interleukin-1 production" NARROW [] +synonym: "negative regulation of IL-1 production" EXACT [] +synonym: "negative regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-1 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: negatively_regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032693 +name: negative regulation of interleukin-10 production +namespace: biological_process +alt_id: GO:0045081 +alt_id: GO:2001180 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "down regulation of interleukin-10 production" EXACT [] +synonym: "down-regulation of interleukin-10 production" EXACT [] +synonym: "downregulation of interleukin-10 production" EXACT [] +synonym: "inhibition of interleukin-10 production" NARROW [] +synonym: "negative regulation of IL-10 production" EXACT [] +synonym: "negative regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-10 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032653 ! regulation of interleukin-10 production +relationship: negatively_regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032694 +name: negative regulation of interleukin-11 production +namespace: biological_process +alt_id: GO:0045364 +alt_id: GO:0150170 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah, PMID:29286137] +synonym: "down regulation of interleukin-11 production" EXACT [] +synonym: "down-regulation of interleukin-11 production" EXACT [] +synonym: "downregulation of interleukin-11 production" EXACT [] +synonym: "inhibition of interleukin-11 production" NARROW [] +synonym: "negative regulation of IL-11 production" EXACT [] +synonym: "negative regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-11 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032654 ! regulation of interleukin-11 production +relationship: negatively_regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032695 +name: negative regulation of interleukin-12 production +namespace: biological_process +alt_id: GO:0045083 +alt_id: GO:2001183 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "down regulation of interleukin-12 production" EXACT [] +synonym: "down-regulation of interleukin-12 production" EXACT [] +synonym: "downregulation of interleukin-12 production" EXACT [] +synonym: "inhibition of interleukin-12 production" NARROW [] +synonym: "negative regulation of CLMF production" RELATED [GOC:obol] +synonym: "negative regulation of IL-12 production" EXACT [] +synonym: "negative regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-12 secretion" NARROW [] +synonym: "negative regulation of NKSF production" RELATED [GOC:obol] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032655 ! regulation of interleukin-12 production +relationship: negatively_regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032696 +name: negative regulation of interleukin-13 production +namespace: biological_process +alt_id: GO:0045367 +alt_id: GO:2000666 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "down regulation of interleukin-13 production" EXACT [] +synonym: "down-regulation of interleukin-13 production" EXACT [] +synonym: "downregulation of interleukin-13 production" EXACT [] +synonym: "inhibition of interleukin-13 production" NARROW [] +synonym: "negative regulation of IL-13 production" EXACT [] +synonym: "negative regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-13 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032656 ! regulation of interleukin-13 production +relationship: negatively_regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032697 +name: obsolete negative regulation of interleukin-14 production +namespace: biological_process +alt_id: GO:0045370 +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "down regulation of interleukin-14 production" EXACT [] +synonym: "down-regulation of interleukin-14 production" EXACT [] +synonym: "downregulation of interleukin-14 production" EXACT [] +synonym: "inhibition of interleukin-14 production" NARROW [] +synonym: "negative regulation of IL-14 production" EXACT [] +synonym: "negative regulation of interleukin-14 biosynthetic process" NARROW [] +is_obsolete: true + +[Term] +id: GO:0032698 +name: negative regulation of interleukin-15 production +namespace: biological_process +alt_id: GO:0045373 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "down regulation of interleukin-15 production" EXACT [] +synonym: "down-regulation of interleukin-15 production" EXACT [] +synonym: "downregulation of interleukin-15 production" EXACT [] +synonym: "inhibition of interleukin-15 production" NARROW [] +synonym: "negative regulation of IL-15 production" EXACT [] +synonym: "negative regulation of interleukin-15 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032658 ! regulation of interleukin-15 production +relationship: negatively_regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032699 +name: negative regulation of interleukin-16 production +namespace: biological_process +alt_id: GO:0045376 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "down regulation of interleukin-16 production" EXACT [] +synonym: "down-regulation of interleukin-16 production" EXACT [] +synonym: "downregulation of interleukin-16 production" EXACT [] +synonym: "inhibition of interleukin-16 production" NARROW [] +synonym: "negative regulation of IL-16 production" EXACT [] +synonym: "negative regulation of interleukin-16 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032659 ! regulation of interleukin-16 production +relationship: negatively_regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032700 +name: negative regulation of interleukin-17 production +namespace: biological_process +alt_id: GO:0045379 +alt_id: GO:1905077 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] +synonym: "down regulation of interleukin-17 production" EXACT [] +synonym: "downregulation of interleukin-17 production" EXACT [] +synonym: "inhibition of interleukin-17 production" NARROW [] +synonym: "negative regulation of CTLA-8 production" NARROW [GOC:TermGenie] +synonym: "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion" EXACT [GOC:TermGenie] +synonym: "negative regulation of IL-17 production" EXACT [] +synonym: "negative regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-17 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032660 ! regulation of interleukin-17 production +relationship: negatively_regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032701 +name: negative regulation of interleukin-18 production +namespace: biological_process +alt_id: GO:0045382 +alt_id: GO:0150121 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah, PMID:23710316] +synonym: "down regulation of interleukin-18 production" EXACT [] +synonym: "down-regulation of interleukin-18 production" EXACT [] +synonym: "downregulation of interleukin-18 production" EXACT [] +synonym: "inhibition of interleukin-18 production" NARROW [] +synonym: "negative regulation of IL-18 production" EXACT [] +synonym: "negative regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-18 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032661 ! regulation of interleukin-18 production +relationship: negatively_regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032702 +name: negative regulation of interleukin-19 production +namespace: biological_process +alt_id: GO:0045385 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "down regulation of interleukin-19 production" EXACT [] +synonym: "down-regulation of interleukin-19 production" EXACT [] +synonym: "downregulation of interleukin-19 production" EXACT [] +synonym: "inhibition of interleukin-19 production" NARROW [] +synonym: "negative regulation of IL-19 production" EXACT [] +synonym: "negative regulation of interleukin-19 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032662 ! regulation of interleukin-19 production +relationship: negatively_regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032703 +name: negative regulation of interleukin-2 production +namespace: biological_process +alt_id: GO:0045085 +alt_id: GO:1900041 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "down regulation of interleukin-2 production" EXACT [] +synonym: "down-regulation of interleukin-2 production" EXACT [] +synonym: "downregulation of interleukin-2 production" EXACT [] +synonym: "inhibition of interleukin-2 production" NARROW [] +synonym: "negative regulation of IL-2 production" EXACT [] +synonym: "negative regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-2 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032663 ! regulation of interleukin-2 production +relationship: negatively_regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032704 +name: negative regulation of interleukin-20 production +namespace: biological_process +alt_id: GO:0045388 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "down regulation of interleukin-20 production" EXACT [] +synonym: "down-regulation of interleukin-20 production" EXACT [] +synonym: "downregulation of interleukin-20 production" EXACT [] +synonym: "inhibition of interleukin-20 production" NARROW [] +synonym: "negative regulation of IL-20 production" EXACT [] +synonym: "negative regulation of interleukin-20 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032664 ! regulation of interleukin-20 production +relationship: negatively_regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032705 +name: negative regulation of interleukin-21 production +namespace: biological_process +alt_id: GO:0045391 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "down regulation of interleukin-21 production" EXACT [] +synonym: "down-regulation of interleukin-21 production" EXACT [] +synonym: "downregulation of interleukin-21 production" EXACT [] +synonym: "negative regulation of interleukin-21 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032665 ! regulation of interleukin-21 production +relationship: negatively_regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032706 +name: negative regulation of interleukin-22 production +namespace: biological_process +alt_id: GO:0045394 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "down regulation of interleukin-22 production" EXACT [] +synonym: "down-regulation of interleukin-22 production" EXACT [] +synonym: "downregulation of interleukin-22 production" EXACT [] +synonym: "inhibition of interleukin-22 production" NARROW [] +synonym: "negative regulation of IL-22 production" EXACT [] +synonym: "negative regulation of interleukin-22 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032666 ! regulation of interleukin-22 production +relationship: negatively_regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032707 +name: negative regulation of interleukin-23 production +namespace: biological_process +alt_id: GO:0045397 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "down regulation of interleukin-23 production" EXACT [] +synonym: "down-regulation of interleukin-23 production" EXACT [] +synonym: "downregulation of interleukin-23 production" EXACT [] +synonym: "inhibition of interleukin-23 production" NARROW [] +synonym: "negative regulation of IL-23 production" EXACT [] +synonym: "negative regulation of interleukin-23 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032667 ! regulation of interleukin-23 production +relationship: negatively_regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032708 +name: negative regulation of interleukin-24 production +namespace: biological_process +alt_id: GO:0045532 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "down regulation of interleukin-24 production" EXACT [] +synonym: "down-regulation of interleukin-24 production" EXACT [] +synonym: "downregulation of interleukin-24 production" EXACT [] +synonym: "inhibition of interleukin-24 production" NARROW [] +synonym: "negative regulation of IL-24 production" EXACT [] +synonym: "negative regulation of interleukin-24 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032668 ! regulation of interleukin-24 production +relationship: negatively_regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032709 +name: negative regulation of interleukin-25 production +namespace: biological_process +alt_id: GO:0045533 +alt_id: GO:0150149 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +synonym: "down regulation of interleukin-25 production" EXACT [] +synonym: "down-regulation of interleukin-25 production" EXACT [] +synonym: "downregulation of interleukin-25 production" EXACT [] +synonym: "inhibition of interleukin-25 production" NARROW [] +synonym: "negative regulation of IL-25 production" EXACT [] +synonym: "negative regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-25 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032669 ! regulation of interleukin-25 production +relationship: negatively_regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032710 +name: negative regulation of interleukin-26 production +namespace: biological_process +alt_id: GO:0045534 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "down regulation of interleukin-26 production" EXACT [] +synonym: "down-regulation of interleukin-26 production" EXACT [] +synonym: "downregulation of interleukin-26 production" EXACT [] +synonym: "inhibition of interleukin-26 production" NARROW [] +synonym: "negative regulation of IL-26 production" EXACT [] +synonym: "negative regulation of interleukin-26 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032670 ! regulation of interleukin-26 production +relationship: negatively_regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032711 +name: negative regulation of interleukin-27 production +namespace: biological_process +alt_id: GO:0045535 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "down regulation of interleukin-27 production" EXACT [] +synonym: "down-regulation of interleukin-27 production" EXACT [] +synonym: "downregulation of interleukin-27 production" EXACT [] +synonym: "inhibition of interleukin-27 production" NARROW [] +synonym: "negative regulation of IL-27 production" EXACT [] +synonym: "negative regulation of interleukin-27 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032671 ! regulation of interleukin-27 production +relationship: negatively_regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032712 +name: negative regulation of interleukin-3 production +namespace: biological_process +alt_id: GO:0045400 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "down regulation of interleukin-3 production" EXACT [] +synonym: "down-regulation of interleukin-3 production" EXACT [] +synonym: "downregulation of interleukin-3 production" EXACT [] +synonym: "inhibition of interleukin-3 production" NARROW [] +synonym: "negative regulation of IL-3 production" EXACT [] +synonym: "negative regulation of interleukin-3 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032672 ! regulation of interleukin-3 production +relationship: negatively_regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032713 +name: negative regulation of interleukin-4 production +namespace: biological_process +alt_id: GO:0045403 +alt_id: GO:0150134 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah, PMID:29778524] +synonym: "down regulation of interleukin-4 production" EXACT [] +synonym: "down-regulation of interleukin-4 production" EXACT [] +synonym: "downregulation of interleukin-4 production" EXACT [] +synonym: "inhibition of interleukin-4 production" NARROW [] +synonym: "negative regulation of IL-4 production" EXACT [] +synonym: "negative regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-4 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032673 ! regulation of interleukin-4 production +relationship: negatively_regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032714 +name: negative regulation of interleukin-5 production +namespace: biological_process +alt_id: GO:0045406 +alt_id: GO:2000663 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "down regulation of interleukin-5 production" EXACT [] +synonym: "down-regulation of interleukin-5 production" EXACT [] +synonym: "downregulation of interleukin-5 production" EXACT [] +synonym: "inhibition of interleukin-5 production" NARROW [] +synonym: "negative regulation of IL-5 production" EXACT [] +synonym: "negative regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-5 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032674 ! regulation of interleukin-5 production +relationship: negatively_regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032715 +name: negative regulation of interleukin-6 production +namespace: biological_process +alt_id: GO:0045409 +alt_id: GO:1900165 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "down regulation of interleukin-6 production" EXACT [] +synonym: "down-regulation of interleukin-6 production" EXACT [] +synonym: "downregulation of interleukin-6 production" EXACT [] +synonym: "inhibition of interleukin-6 production" NARROW [] +synonym: "negative regulation of IL-6 production" EXACT [] +synonym: "negative regulation of interleukin-6 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-6 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032675 ! regulation of interleukin-6 production +relationship: negatively_regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032716 +name: negative regulation of interleukin-7 production +namespace: biological_process +alt_id: GO:0045412 +alt_id: GO:0150113 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah, PMID:25962782] +synonym: "down regulation of interleukin-7 production" EXACT [] +synonym: "down-regulation of interleukin-7 production" EXACT [] +synonym: "downregulation of interleukin-7 production" EXACT [] +synonym: "inhibition of interleukin-7 production" NARROW [] +synonym: "negative regulation of IL-7 production" EXACT [] +synonym: "negative regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-7 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032676 ! regulation of interleukin-7 production +relationship: negatively_regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032717 +name: negative regulation of interleukin-8 production +namespace: biological_process +alt_id: GO:0045415 +alt_id: GO:2000483 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "down regulation of interleukin-8 production" EXACT [] +synonym: "down-regulation of interleukin-8 production" EXACT [] +synonym: "downregulation of interleukin-8 production" EXACT [] +synonym: "inhibition of interleukin-8 production" NARROW [] +synonym: "negative regulation of IL-8 production" EXACT [] +synonym: "negative regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-8 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032677 ! regulation of interleukin-8 production +relationship: negatively_regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032718 +name: negative regulation of interleukin-9 production +namespace: biological_process +alt_id: GO:0045418 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "down regulation of interleukin-9 production" EXACT [] +synonym: "down-regulation of interleukin-9 production" EXACT [] +synonym: "downregulation of interleukin-9 production" EXACT [] +synonym: "inhibition of interleukin-9 production" NARROW [] +synonym: "negative regulation of IL-9 production" EXACT [] +synonym: "negative regulation of interleukin-9 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0032678 ! regulation of interleukin-9 production +relationship: negatively_regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032719 +name: negative regulation of TRAIL production +namespace: biological_process +alt_id: GO:0045555 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah] +synonym: "down regulation of TRAIL production" EXACT [] +synonym: "down-regulation of TRAIL production" EXACT [] +synonym: "downregulation of TRAIL production" EXACT [] +synonym: "inhibition of TRAIL production" NARROW [] +synonym: "negative regulation of TRAIL biosynthetic process" NARROW [] +is_a: GO:0032679 ! regulation of TRAIL production +is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production +relationship: negatively_regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032720 +name: negative regulation of tumor necrosis factor production +namespace: biological_process +alt_id: GO:0042536 +alt_id: GO:1904468 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah, PMID:10891884, PMID:15560120] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "down regulation of tumor necrosis factor production" EXACT [] +synonym: "down-regulation of tumor necrosis factor production" EXACT [] +synonym: "downregulation of tumor necrosis factor production" EXACT [] +synonym: "inhibition of cachectin production" NARROW [GOC:TermGenie] +synonym: "inhibition of tumor necrosis factor production" NARROW [] +synonym: "negative regulation of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "negative regulation of tumor necrosis factor secretion" NARROW [] +synonym: "negative regulation TNF production" EXACT [] +synonym: "negative regulation TNF-alpha production" EXACT [] +synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] +is_a: GO:0032680 ! regulation of tumor necrosis factor production +is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production +relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032721 +name: negative regulation of lymphotoxin A production +namespace: biological_process +alt_id: GO:0043018 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "down regulation of lymphotoxin A production" EXACT [] +synonym: "down-regulation of lymphotoxin A production" EXACT [] +synonym: "downregulation of lymphotoxin A production" EXACT [] +synonym: "inhibition of lymphotoxin A production" NARROW [] +synonym: "negative regulation of LTA production" EXACT [] +synonym: "negative regulation of lymphotoxin A biosynthetic process" NARROW [] +synonym: "negative regulation of lymphotoxin-alpha production" EXACT [] +synonym: "negative regulation of TNF-beta production" EXACT [] +synonym: "negative regulation of tumor necrosis factor-beta production" EXACT [] +is_a: GO:0032681 ! regulation of lymphotoxin A production +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production +relationship: negatively_regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032722 +name: positive regulation of chemokine production +namespace: biological_process +alt_id: GO:0045080 +alt_id: GO:0090197 +def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah] +synonym: "activation of chemokine production" NARROW [] +synonym: "positive regulation of chemokine biosynthetic process" NARROW [] +synonym: "positive regulation of chemokine secretion" NARROW [] +synonym: "stimulation of chemokine production" NARROW [] +synonym: "up regulation of chemokine production" EXACT [] +synonym: "up-regulation of chemokine production" EXACT [] +synonym: "upregulation of chemokine production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032642 ! regulation of chemokine production +relationship: positively_regulates GO:0032602 ! chemokine production + +[Term] +id: GO:0032723 +name: positive regulation of connective tissue growth factor production +namespace: biological_process +alt_id: GO:0045422 +def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] +synonym: "activation of connective tissue growth factor production" NARROW [] +synonym: "positive regulation of CCN2 production" EXACT [] +synonym: "positive regulation of connective tissue growth factor biosynthetic process" NARROW [] +synonym: "positive regulation of CTGF production" EXACT [] +synonym: "positive regulation of Fisp12 production" EXACT [] +synonym: "positive regulation of Hcs24 production" EXACT [] +synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] +synonym: "positive regulation of IGFBP8 production" EXACT [] +synonym: "stimulation of connective tissue growth factor production" NARROW [] +synonym: "up regulation of connective tissue growth factor production" EXACT [] +synonym: "up-regulation of connective tissue growth factor production" EXACT [] +synonym: "upregulation of connective tissue growth factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032643 ! regulation of connective tissue growth factor production +relationship: positively_regulates GO:0032601 ! connective tissue growth factor production + +[Term] +id: GO:0032724 +name: positive regulation of fractalkine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah] +synonym: "activation of fractalkine production" NARROW [] +synonym: "stimulation of fractalkine production" NARROW [] +synonym: "up regulation of fractalkine production" EXACT [] +synonym: "up-regulation of fractalkine production" EXACT [] +synonym: "upregulation of fractalkine production" EXACT [] +is_a: GO:0032644 ! regulation of fractalkine production +is_a: GO:0032722 ! positive regulation of chemokine production +relationship: positively_regulates GO:0032603 ! fractalkine production + +[Term] +id: GO:0032725 +name: positive regulation of granulocyte macrophage colony-stimulating factor production +namespace: biological_process +alt_id: GO:0045425 +def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] +synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW [] +synonym: "positive regulation of GM-CSF production" EXACT [GOC:vk] +synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT [] +synonym: "positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process" NARROW [] +synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW [] +synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production + +[Term] +id: GO:0032726 +name: positive regulation of hepatocyte growth factor production +namespace: biological_process +alt_id: GO:0048177 +def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah, PMID:1838014] +synonym: "activation of hepatocyte growth factor production" NARROW [] +synonym: "positive regulation of hepatocyte growth factor biosynthetic process" NARROW [] +synonym: "positive regulation of HGF production" EXACT [] +synonym: "positive regulation of scatter factor production" EXACT [] +synonym: "stimulation of hepatocyte growth factor production" NARROW [] +synonym: "up regulation of hepatocyte growth factor production" EXACT [] +synonym: "up-regulation of hepatocyte growth factor production" EXACT [] +synonym: "upregulation of hepatocyte growth factor production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032646 ! regulation of hepatocyte growth factor production +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production + +[Term] +id: GO:0032727 +name: positive regulation of interferon-alpha production +namespace: biological_process +alt_id: GO:0045356 +alt_id: GO:1902741 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah, PMID:15546383] +synonym: "activation of interferon-alpha production" NARROW [] +synonym: "positive regulation of interferon-alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-alpha secretion" NARROW [] +synonym: "stimulation of interferon-alpha production" NARROW [] +synonym: "up regulation of interferon-alpha production" EXACT [] +synonym: "up-regulation of interferon-alpha production" EXACT [] +synonym: "upregulation of interferon-alpha production" EXACT [] +is_a: GO:0032481 ! positive regulation of type I interferon production +is_a: GO:0032647 ! regulation of interferon-alpha production +relationship: positively_regulates GO:0032607 ! interferon-alpha production + +[Term] +id: GO:0032728 +name: positive regulation of interferon-beta production +namespace: biological_process +alt_id: GO:0035549 +alt_id: GO:0045359 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah, PMID:15546383] +synonym: "activation of interferon-beta production" NARROW [] +synonym: "positive regulation of IFN-beta production" EXACT [] +synonym: "positive regulation of interferon-beta biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-beta secretion" NARROW [] +synonym: "stimulation of interferon-beta production" NARROW [] +synonym: "up regulation of interferon-beta production" EXACT [] +synonym: "up-regulation of interferon-beta production" EXACT [] +synonym: "upregulation of interferon-beta production" EXACT [] +is_a: GO:0032481 ! positive regulation of type I interferon production +is_a: GO:0032648 ! regulation of interferon-beta production +relationship: positively_regulates GO:0032608 ! interferon-beta production + +[Term] +id: GO:0032729 +name: positive regulation of interferon-gamma production +namespace: biological_process +alt_id: GO:0045078 +alt_id: GO:1902715 +def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah, PMID:15546383] +synonym: "activation of interferon-gamma production" NARROW [] +synonym: "positive regulation of interferon-gamma biosynthetic process" NARROW [] +synonym: "positive regulation of interferon-gamma secretion" NARROW [] +synonym: "positive regulation of type II interferon production" BROAD [] +synonym: "stimulation of interferon-gamma production" NARROW [] +synonym: "up regulation of interferon-gamma production" EXACT [] +synonym: "up-regulation of interferon-gamma production" EXACT [] +synonym: "upregulation of interferon-gamma production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032649 ! regulation of interferon-gamma production +relationship: positively_regulates GO:0032609 ! interferon-gamma production + +[Term] +id: GO:0032730 +name: positive regulation of interleukin-1 alpha production +namespace: biological_process +alt_id: GO:0050717 +alt_id: GO:0050726 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] +synonym: "activation of interleukin-1 alpha production" NARROW [] +synonym: "positive regulation of IL-1 alpha production" EXACT [] +synonym: "positive regulation of interleukin-1 alpha biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 alpha secretion" NARROW [] +synonym: "stimulation of interleukin-1 alpha production" NARROW [] +synonym: "up regulation of interleukin-1 alpha production" EXACT [] +synonym: "up-regulation of interleukin-1 alpha production" EXACT [] +synonym: "upregulation of interleukin-1 alpha production" EXACT [] +is_a: GO:0032650 ! regulation of interleukin-1 alpha production +is_a: GO:0032732 ! positive regulation of interleukin-1 production +relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production + +[Term] +id: GO:0032731 +name: positive regulation of interleukin-1 beta production +namespace: biological_process +alt_id: GO:0050718 +alt_id: GO:0050725 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] +synonym: "activation of interleukin-1 beta production" NARROW [] +synonym: "positive regulation of IL-1 beta production" EXACT [] +synonym: "positive regulation of interleukin-1 beta biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 beta secretion" NARROW [] +synonym: "stimulation of interleukin-1 beta production" NARROW [] +synonym: "up regulation of interleukin-1 beta production" EXACT [] +synonym: "up-regulation of interleukin-1 beta production" EXACT [] +synonym: "upregulation of interleukin-1 beta production" EXACT [] +is_a: GO:0032651 ! regulation of interleukin-1 beta production +is_a: GO:0032732 ! positive regulation of interleukin-1 production +relationship: positively_regulates GO:0032611 ! interleukin-1 beta production + +[Term] +id: GO:0032732 +name: positive regulation of interleukin-1 production +namespace: biological_process +alt_id: GO:0045362 +alt_id: GO:0050716 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] +synonym: "activation of interleukin-1 production" NARROW [] +synonym: "positive regulation of IL-1 production" EXACT [] +synonym: "positive regulation of interleukin-1 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-1 secretion" NARROW [] +synonym: "stimulation of interleukin-1 production" NARROW [] +synonym: "up regulation of interleukin-1 production" EXACT [] +synonym: "up-regulation of interleukin-1 production" EXACT [] +synonym: "upregulation of interleukin-1 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032652 ! regulation of interleukin-1 production +relationship: positively_regulates GO:0032612 ! interleukin-1 production + +[Term] +id: GO:0032733 +name: positive regulation of interleukin-10 production +namespace: biological_process +alt_id: GO:0045082 +alt_id: GO:2001181 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] +synonym: "activation of interleukin-10 production" NARROW [] +synonym: "positive regulation of IL-10 production" EXACT [] +synonym: "positive regulation of interleukin-10 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-10 secretion" NARROW [] +synonym: "stimulation of interleukin-10 production" NARROW [] +synonym: "up regulation of interleukin-10 production" EXACT [] +synonym: "up-regulation of interleukin-10 production" EXACT [] +synonym: "upregulation of interleukin-10 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032653 ! regulation of interleukin-10 production +relationship: positively_regulates GO:0032613 ! interleukin-10 production + +[Term] +id: GO:0032734 +name: positive regulation of interleukin-11 production +namespace: biological_process +alt_id: GO:0045365 +alt_id: GO:0150171 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] +synonym: "activation of interleukin-11 production" NARROW [] +synonym: "positive regulation of IL-11 production" EXACT [] +synonym: "positive regulation of interleukin-11 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-11 secretion" NARROW [] +synonym: "stimulation of interleukin-11 production" NARROW [] +synonym: "up regulation of interleukin-11 production" EXACT [] +synonym: "up-regulation of interleukin-11 production" EXACT [] +synonym: "upregulation of interleukin-11 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032654 ! regulation of interleukin-11 production +relationship: positively_regulates GO:0032614 ! interleukin-11 production + +[Term] +id: GO:0032735 +name: positive regulation of interleukin-12 production +namespace: biological_process +alt_id: GO:0045084 +alt_id: GO:2001184 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] +synonym: "activation of interleukin-12 production" NARROW [] +synonym: "positive regulation of CLMF production" RELATED [GOC:obol] +synonym: "positive regulation of IL-12 production" EXACT [] +synonym: "positive regulation of interleukin-12 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-12 secretion" NARROW [] +synonym: "positive regulation of NKSF production" RELATED [GOC:obol] +synonym: "stimulation of interleukin-12 production" NARROW [] +synonym: "up regulation of interleukin-12 production" EXACT [] +synonym: "up-regulation of interleukin-12 production" EXACT [] +synonym: "upregulation of interleukin-12 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032655 ! regulation of interleukin-12 production +relationship: positively_regulates GO:0032615 ! interleukin-12 production + +[Term] +id: GO:0032736 +name: positive regulation of interleukin-13 production +namespace: biological_process +alt_id: GO:0045368 +alt_id: GO:2000667 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] +synonym: "activation of interleukin-13 production" NARROW [] +synonym: "positive regulation of IL-13 production" EXACT [] +synonym: "positive regulation of interleukin-13 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-13 secretion" NARROW [] +synonym: "stimulation of interleukin-13 production" NARROW [] +synonym: "up regulation of interleukin-13 production" EXACT [] +synonym: "up-regulation of interleukin-13 production" EXACT [] +synonym: "upregulation of interleukin-13 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032656 ! regulation of interleukin-13 production +relationship: positively_regulates GO:0032616 ! interleukin-13 production + +[Term] +id: GO:0032737 +name: obsolete positive regulation of interleukin-14 production +namespace: biological_process +alt_id: GO:0045371 +def: "OBSOLETE. Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] +comment: This term was obsoleted because the gene was shown not to exist, see PMID:8755619. +synonym: "activation of interleukin-14 production" NARROW [] +synonym: "positive regulation of IL-14 production" EXACT [] +synonym: "positive regulation of interleukin-14 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-14 production" NARROW [] +synonym: "up regulation of interleukin-14 production" EXACT [] +synonym: "up-regulation of interleukin-14 production" EXACT [] +synonym: "upregulation of interleukin-14 production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0032738 +name: positive regulation of interleukin-15 production +namespace: biological_process +alt_id: GO:0045374 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] +synonym: "activation of interleukin-15 production" NARROW [] +synonym: "positive regulation of IL-15 production" EXACT [] +synonym: "positive regulation of interleukin-15 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-15 production" NARROW [] +synonym: "up regulation of interleukin-15 production" EXACT [] +synonym: "up-regulation of interleukin-15 production" EXACT [] +synonym: "upregulation of interleukin-15 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032658 ! regulation of interleukin-15 production +relationship: positively_regulates GO:0032618 ! interleukin-15 production + +[Term] +id: GO:0032739 +name: positive regulation of interleukin-16 production +namespace: biological_process +alt_id: GO:0045377 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] +synonym: "activation of interleukin-16 production" NARROW [] +synonym: "positive regulation of IL-16 production" EXACT [] +synonym: "positive regulation of interleukin-16 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-16 production" NARROW [] +synonym: "up regulation of interleukin-16 production" EXACT [] +synonym: "up-regulation of interleukin-16 production" EXACT [] +synonym: "upregulation of interleukin-16 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032659 ! regulation of interleukin-16 production +relationship: positively_regulates GO:0032619 ! interleukin-16 production + +[Term] +id: GO:0032740 +name: positive regulation of interleukin-17 production +namespace: biological_process +alt_id: GO:0045380 +alt_id: GO:1905078 +def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah, PMID:16482511] +synonym: "activation of interleukin-17 production" NARROW [] +synonym: "positive regulation of CTLA-8 production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production" EXACT [GOC:TermGenie] +synonym: "positive regulation of IL-17 production" EXACT [] +synonym: "positive regulation of interleukin-17 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-17 secretion" NARROW [] +synonym: "stimulation of interleukin-17 production" NARROW [] +synonym: "up regulation of interleukin-17 production" EXACT [] +synonym: "up-regulation of interleukin-17 production" EXACT [] +synonym: "upregulation of interleukin-17 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032660 ! regulation of interleukin-17 production +relationship: positively_regulates GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0032741 +name: positive regulation of interleukin-18 production +namespace: biological_process +alt_id: GO:0045383 +alt_id: GO:0150122 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] +synonym: "activation of interleukin-18 production" NARROW [] +synonym: "positive regulation of IL-18 production" EXACT [] +synonym: "positive regulation of interleukin-18 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-18 secretion" NARROW [] +synonym: "stimulation of interleukin-18 production" NARROW [] +synonym: "up regulation of interleukin-18 production" EXACT [] +synonym: "up-regulation of interleukin-18 production" EXACT [] +synonym: "upregulation of interleukin-18 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032661 ! regulation of interleukin-18 production +relationship: positively_regulates GO:0032621 ! interleukin-18 production + +[Term] +id: GO:0032742 +name: positive regulation of interleukin-19 production +namespace: biological_process +alt_id: GO:0045386 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] +synonym: "activation of interleukin-19 production" NARROW [] +synonym: "positive regulation of IL-19 production" EXACT [] +synonym: "positive regulation of interleukin-19 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-19 production" NARROW [] +synonym: "up regulation of interleukin-19 production" EXACT [] +synonym: "up-regulation of interleukin-19 production" EXACT [] +synonym: "upregulation of interleukin-19 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032662 ! regulation of interleukin-19 production +relationship: positively_regulates GO:0032622 ! interleukin-19 production + +[Term] +id: GO:0032743 +name: positive regulation of interleukin-2 production +namespace: biological_process +alt_id: GO:0045086 +alt_id: GO:1900042 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] +synonym: "activation of interleukin-2 production" NARROW [] +synonym: "positive regulation of IL-2 production" EXACT [] +synonym: "positive regulation of interleukin-2 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-2 secretion" NARROW [] +synonym: "stimulation of interleukin-2 production" NARROW [] +synonym: "up regulation of interleukin-2 production" EXACT [] +synonym: "up-regulation of interleukin-2 production" EXACT [] +synonym: "upregulation of interleukin-2 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032663 ! regulation of interleukin-2 production +relationship: positively_regulates GO:0032623 ! interleukin-2 production + +[Term] +id: GO:0032744 +name: positive regulation of interleukin-20 production +namespace: biological_process +alt_id: GO:0045389 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] +synonym: "activation of interleukin-20 production" NARROW [] +synonym: "positive regulation of IL-20 production" EXACT [] +synonym: "positive regulation of interleukin-20 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-20 production" NARROW [] +synonym: "up regulation of interleukin-20 production" EXACT [] +synonym: "up-regulation of interleukin-20 production" EXACT [] +synonym: "upregulation of interleukin-20 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032664 ! regulation of interleukin-20 production +relationship: positively_regulates GO:0032624 ! interleukin-20 production + +[Term] +id: GO:0032745 +name: positive regulation of interleukin-21 production +namespace: biological_process +alt_id: GO:0045392 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] +synonym: "activation of interleukin-21 production" NARROW [] +synonym: "positive regulation of IL-21 production" EXACT [] +synonym: "positive regulation of interleukin-21 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-21 production" NARROW [] +synonym: "up regulation of interleukin-21 production" EXACT [] +synonym: "up-regulation of interleukin-21 production" EXACT [] +synonym: "upregulation of interleukin-21 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032665 ! regulation of interleukin-21 production +relationship: positively_regulates GO:0032625 ! interleukin-21 production + +[Term] +id: GO:0032746 +name: positive regulation of interleukin-22 production +namespace: biological_process +alt_id: GO:0045395 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] +synonym: "activation of interleukin-22 production" NARROW [] +synonym: "positive regulation of IL-22 production" EXACT [] +synonym: "positive regulation of interleukin-22 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-22 production" NARROW [] +synonym: "up regulation of interleukin-22 production" EXACT [] +synonym: "up-regulation of interleukin-22 production" EXACT [] +synonym: "upregulation of interleukin-22 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032666 ! regulation of interleukin-22 production +relationship: positively_regulates GO:0032626 ! interleukin-22 production + +[Term] +id: GO:0032747 +name: positive regulation of interleukin-23 production +namespace: biological_process +alt_id: GO:0045398 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] +synonym: "activation of interleukin-23 production" NARROW [] +synonym: "positive regulation of IL-23 production" EXACT [] +synonym: "positive regulation of interleukin-23 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-23 production" NARROW [] +synonym: "up regulation of interleukin-23 production" EXACT [] +synonym: "up-regulation of interleukin-23 production" EXACT [] +synonym: "upregulation of interleukin-23 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032667 ! regulation of interleukin-23 production +relationship: positively_regulates GO:0032627 ! interleukin-23 production + +[Term] +id: GO:0032748 +name: positive regulation of interleukin-24 production +namespace: biological_process +alt_id: GO:0045536 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] +synonym: "activation of interleukin-24 production" NARROW [] +synonym: "positive regulation of IL-24 production" EXACT [] +synonym: "positive regulation of interleukin-24 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-24 production" NARROW [] +synonym: "up regulation of interleukin-24 production" EXACT [] +synonym: "up-regulation of interleukin-24 production" EXACT [] +synonym: "upregulation of interleukin-24 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032668 ! regulation of interleukin-24 production +relationship: positively_regulates GO:0032628 ! interleukin-24 production + +[Term] +id: GO:0032749 +name: positive regulation of interleukin-25 production +namespace: biological_process +alt_id: GO:0045537 +alt_id: GO:0150150 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] +synonym: "activation of interleukin-25 production" NARROW [] +synonym: "positive regulation of IL-25 production" EXACT [] +synonym: "positive regulation of interleukin-25 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-25 secretion" NARROW [] +synonym: "stimulation of interleukin-25 production" NARROW [] +synonym: "up regulation of interleukin-25 production" EXACT [] +synonym: "up-regulation of interleukin-25 production" EXACT [] +synonym: "upregulation of interleukin-25 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032669 ! regulation of interleukin-25 production +relationship: positively_regulates GO:0032629 ! interleukin-25 production + +[Term] +id: GO:0032750 +name: positive regulation of interleukin-26 production +namespace: biological_process +alt_id: GO:0045538 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] +synonym: "activation of interleukin-26 production" NARROW [] +synonym: "positive regulation of IL-26 production" EXACT [] +synonym: "positive regulation of interleukin-26 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-26 production" NARROW [] +synonym: "up regulation of interleukin-26 production" EXACT [] +synonym: "up-regulation of interleukin-26 production" EXACT [] +synonym: "upregulation of interleukin-26 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032670 ! regulation of interleukin-26 production +relationship: positively_regulates GO:0032630 ! interleukin-26 production + +[Term] +id: GO:0032751 +name: positive regulation of interleukin-27 production +namespace: biological_process +alt_id: GO:0045539 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] +synonym: "activation of interleukin-27 production" NARROW [] +synonym: "positive regulation of IL-27 production" EXACT [] +synonym: "positive regulation of interleukin-27 anabolism" NARROW [] +synonym: "positive regulation of interleukin-27 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-27 production" NARROW [] +synonym: "up regulation of interleukin-27 production" EXACT [] +synonym: "up-regulation of interleukin-27 production" EXACT [] +synonym: "upregulation of interleukin-27 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032671 ! regulation of interleukin-27 production +relationship: positively_regulates GO:0032631 ! interleukin-27 production + +[Term] +id: GO:0032752 +name: positive regulation of interleukin-3 production +namespace: biological_process +alt_id: GO:0045401 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] +synonym: "activation of interleukin-3 production" NARROW [] +synonym: "positive regulation of IL-3 production" EXACT [] +synonym: "positive regulation of interleukin-3 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-3 production" NARROW [] +synonym: "up regulation of interleukin-3 production" EXACT [] +synonym: "up-regulation of interleukin-3 production" EXACT [] +synonym: "upregulation of interleukin-3 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032672 ! regulation of interleukin-3 production +relationship: positively_regulates GO:0032632 ! interleukin-3 production + +[Term] +id: GO:0032753 +name: positive regulation of interleukin-4 production +namespace: biological_process +alt_id: GO:0045404 +alt_id: GO:0150135 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] +synonym: "activation of interleukin-4 production" NARROW [] +synonym: "positive regulation of IL-4 production" EXACT [] +synonym: "positive regulation of interleukin-4 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-4 secretion" NARROW [] +synonym: "stimulation of interleukin-4 production" NARROW [] +synonym: "up regulation of interleukin-4 production" EXACT [] +synonym: "up-regulation of interleukin-4 production" EXACT [] +synonym: "upregulation of interleukin-4 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032673 ! regulation of interleukin-4 production +relationship: positively_regulates GO:0032633 ! interleukin-4 production + +[Term] +id: GO:0032754 +name: positive regulation of interleukin-5 production +namespace: biological_process +alt_id: GO:0045407 +alt_id: GO:2000664 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] +synonym: "activation of interleukin-5 production" NARROW [] +synonym: "positive regulation of IL-5 production" EXACT [] +synonym: "positive regulation of interleukin-5 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-5 secretion" NARROW [] +synonym: "stimulation of interleukin-5 production" NARROW [] +synonym: "up regulation of interleukin-5 production" EXACT [] +synonym: "up-regulation of interleukin-5 production" EXACT [] +synonym: "upregulation of interleukin-5 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032674 ! regulation of interleukin-5 production +relationship: positively_regulates GO:0032634 ! interleukin-5 production + +[Term] +id: GO:0032755 +name: positive regulation of interleukin-6 production +namespace: biological_process +alt_id: GO:0045410 +alt_id: GO:2000778 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] +synonym: "activation of interleukin-6 production" NARROW [] +synonym: "positive regulation of IL-6 production" EXACT [] +synonym: "positive regulation of interleukin-6 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-6 secretion" NARROW [] +synonym: "stimulation of interleukin-6 production" NARROW [] +synonym: "up regulation of interleukin-6 production" EXACT [] +synonym: "up-regulation of interleukin-6 production" EXACT [] +synonym: "upregulation of interleukin-6 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032675 ! regulation of interleukin-6 production +relationship: positively_regulates GO:0032635 ! interleukin-6 production + +[Term] +id: GO:0032756 +name: positive regulation of interleukin-7 production +namespace: biological_process +alt_id: GO:0045413 +alt_id: GO:0150114 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] +synonym: "activation of interleukin-7 production" NARROW [] +synonym: "positive regulation of IL-7 production" EXACT [] +synonym: "positive regulation of interleukin-7 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-7 secretion" NARROW [] +synonym: "stimulation of interleukin-7 production" NARROW [] +synonym: "up regulation of interleukin-7 production" EXACT [] +synonym: "up-regulation of interleukin-7 production" EXACT [] +synonym: "upregulation of interleukin-7 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032676 ! regulation of interleukin-7 production +relationship: positively_regulates GO:0032636 ! interleukin-7 production + +[Term] +id: GO:0032757 +name: positive regulation of interleukin-8 production +namespace: biological_process +alt_id: GO:0045416 +alt_id: GO:2000484 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] +synonym: "activation of interleukin-8 production" NARROW [] +synonym: "positive regulation of IL-8 production" EXACT [] +synonym: "positive regulation of interleukin-8 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-8 secretion" NARROW [] +synonym: "stimulation of interleukin-8 production" NARROW [] +synonym: "up regulation of interleukin-8 production" EXACT [] +synonym: "up-regulation of interleukin-8 production" EXACT [] +synonym: "upregulation of interleukin-8 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032677 ! regulation of interleukin-8 production +relationship: positively_regulates GO:0032637 ! interleukin-8 production + +[Term] +id: GO:0032758 +name: positive regulation of interleukin-9 production +namespace: biological_process +alt_id: GO:0045419 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] +synonym: "activation of interleukin-9 production" NARROW [] +synonym: "positive regulation of IL-9 production" EXACT [] +synonym: "positive regulation of interleukin-9 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-9 production" NARROW [] +synonym: "up regulation of interleukin-9 production" EXACT [] +synonym: "up-regulation of interleukin-9 production" EXACT [] +synonym: "upregulation of interleukin-9 production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0032678 ! regulation of interleukin-9 production +relationship: positively_regulates GO:0032638 ! interleukin-9 production + +[Term] +id: GO:0032759 +name: positive regulation of TRAIL production +namespace: biological_process +alt_id: GO:0045556 +def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah] +synonym: "activation of TRAIL production" NARROW [] +synonym: "positive regulation of TRAIL biosynthetic process" NARROW [] +synonym: "stimulation of TRAIL production" NARROW [] +synonym: "up regulation of TRAIL production" EXACT [] +synonym: "up-regulation of TRAIL production" EXACT [] +synonym: "upregulation of TRAIL production" EXACT [] +is_a: GO:0032679 ! regulation of TRAIL production +is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production +relationship: positively_regulates GO:0032639 ! TRAIL production + +[Term] +id: GO:0032760 +name: positive regulation of tumor necrosis factor production +namespace: biological_process +alt_id: GO:0042535 +alt_id: GO:1904469 +def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production." [GO_REF:0000058, GOC:TermGenie, PMID:10891884, PMID:15560120] +comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). +synonym: "activation of tumor necrosis factor production" NARROW [] +synonym: "positive regulation of cachectin secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of TNF production" EXACT [] +synonym: "positive regulation of TNF secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of TNF-alpha production" EXACT [] +synonym: "positive regulation of tumor necrosis factor biosynthesis" NARROW [] +synonym: "positive regulation of tumor necrosis factor biosynthetic process" NARROW [] +synonym: "positive regulation of tumor necrosis factor formation" NARROW [] +synonym: "positive regulation of tumor necrosis factor secretion" NARROW [] +synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] +synonym: "stimulation of tumor necrosis factor production" NARROW [] +synonym: "up regulation of tumor necrosis factor production" EXACT [] +synonym: "up-regulation of tumor necrosis factor production" EXACT [] +synonym: "upregulation of tumor necrosis factor production" EXACT [] +is_a: GO:0032680 ! regulation of tumor necrosis factor production +is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production +relationship: positively_regulates GO:0032640 ! tumor necrosis factor production + +[Term] +id: GO:0032761 +name: positive regulation of lymphotoxin A production +namespace: biological_process +alt_id: GO:0043017 +def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] +synonym: "activation of lymphotoxin A production" NARROW [] +synonym: "positive regulation of LTA production" EXACT [] +synonym: "positive regulation of lymphotoxin A biosynthetic process" NARROW [] +synonym: "positive regulation of lymphotoxin-alpha production" EXACT [] +synonym: "positive regulation of TNF-beta production" EXACT [] +synonym: "positive regulation of tumor necrosis factor-beta production" EXACT [] +synonym: "stimulation of lymphotoxin A production" NARROW [] +synonym: "up regulation of lymphotoxin A production" EXACT [] +synonym: "up-regulation of lymphotoxin A production" EXACT [] +synonym: "upregulation of lymphotoxin A production" EXACT [] +is_a: GO:0032681 ! regulation of lymphotoxin A production +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production +relationship: positively_regulates GO:0032641 ! lymphotoxin A production + +[Term] +id: GO:0032762 +name: mast cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0061082 ! myeloid leukocyte cytokine production + +[Term] +id: GO:0032763 +name: regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +is_a: GO:0002718 ! regulation of cytokine production involved in immune response +relationship: regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032764 +name: negative regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +synonym: "down regulation of mast cell cytokine production" EXACT [] +synonym: "down-regulation of mast cell cytokine production" EXACT [] +synonym: "downregulation of mast cell cytokine production" EXACT [] +synonym: "inhibition of mast cell cytokine production" NARROW [] +is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response +is_a: GO:0032763 ! regulation of mast cell cytokine production +relationship: negatively_regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032765 +name: positive regulation of mast cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] +synonym: "activation of mast cell cytokine production" NARROW [] +synonym: "stimulation of mast cell cytokine production" NARROW [] +synonym: "up regulation of mast cell cytokine production" EXACT [] +synonym: "up-regulation of mast cell cytokine production" EXACT [] +synonym: "upregulation of mast cell cytokine production" EXACT [] +is_a: GO:0032763 ! regulation of mast cell cytokine production +is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response +relationship: positively_regulates GO:0032762 ! mast cell cytokine production + +[Term] +id: GO:0032766 +name: NHE3/E3KARP/ACTN4 complex +namespace: cellular_component +def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] +synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0032767 +name: copper-dependent protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex, in the presence of copper." [GOC:ecd, PMID:16884690] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032768 +name: regulation of monooxygenase activity +namespace: biological_process +def: "Any process that modulates the activity of a monooxygenase." [GOC:mah] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0032769 +name: negative regulation of monooxygenase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah] +synonym: "down regulation of monooxygenase activity" EXACT [] +synonym: "down-regulation of monooxygenase activity" EXACT [] +synonym: "downregulation of monooxygenase activity" EXACT [] +synonym: "inhibition of monooxygenase activity" NARROW [] +is_a: GO:0032768 ! regulation of monooxygenase activity +is_a: GO:0051354 ! negative regulation of oxidoreductase activity + +[Term] +id: GO:0032770 +name: positive regulation of monooxygenase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah] +synonym: "activation of monooxygenase activity" NARROW [] +synonym: "stimulation of monooxygenase activity" NARROW [] +synonym: "up regulation of monooxygenase activity" EXACT [] +synonym: "up-regulation of monooxygenase activity" EXACT [] +synonym: "upregulation of monooxygenase activity" EXACT [] +is_a: GO:0032768 ! regulation of monooxygenase activity +is_a: GO:0051353 ! positive regulation of oxidoreductase activity + +[Term] +id: GO:0032771 +name: regulation of tyrosinase activity +namespace: biological_process +def: "Any process that modulates the activity of a tyrosinase enzyme." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] +synonym: "regulation of monophenol monooxygenase activity" RELATED [] +synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0032772 +name: negative regulation of tyrosinase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a tyrosinase enzyme." [GOC:dph, GOC:mah, GOC:tb] +synonym: "down regulation of monophenol oxygenase activity" EXACT [] +synonym: "down-regulation of monophenol oxygenase activity" EXACT [] +synonym: "downregulation of monophenol oxygenase activity" EXACT [] +synonym: "inhibition of monophenol oxygenase activity" NARROW [] +synonym: "negative regulation of monophenol monooxygenase activity" RELATED [] +synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0032771 ! regulation of tyrosinase activity + +[Term] +id: GO:0032773 +name: positive regulation of tyrosinase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a tyrosinase enzyme monophenol oxygenase." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] +synonym: "activation of monophenol oxygenase activity" NARROW [] +synonym: "positive regulation of monophenol monooxygenase activity" RELATED [] +synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] +synonym: "stimulation of monophenol oxygenase activity" NARROW [] +synonym: "up regulation of monophenol oxygenase activity" EXACT [] +synonym: "up-regulation of monophenol oxygenase activity" EXACT [] +synonym: "upregulation of monophenol oxygenase activity" EXACT [] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0032771 ! regulation of tyrosinase activity + +[Term] +id: GO:0032774 +name: RNA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] +comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. +synonym: "RNA anabolism" EXACT [] +synonym: "RNA biosynthesis" EXACT [] +synonym: "RNA formation" EXACT [] +synonym: "RNA synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process + +[Term] +id: GO:0032775 +name: DNA methylation on adenine +namespace: biological_process +def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf] +synonym: "adenine methylation" RELATED [] +is_a: GO:0006306 ! DNA methylation + +[Term] +id: GO:0032776 +name: DNA methylation on cytosine +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf] +synonym: "cytosine methylation" BROAD [] +is_a: GO:0006306 ! DNA methylation + +[Term] +id: GO:0032777 +name: Piccolo NuA4 histone acetyltransferase complex +namespace: cellular_component +def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809] +is_a: GO:0035267 ! NuA4 histone acetyltransferase complex + +[Term] +id: GO:0032778 +name: P-type cobalt transporter activity +namespace: molecular_function +alt_id: GO:0015632 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] +synonym: "ATP-dependent cobalt transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled cobalt transmembrane transporter activity" RELATED [] +synonym: "cobalt porter activity" RELATED [] +synonym: "cobalt transporting ATPase activity" RELATED [] +synonym: "cobalt-transporting ATPase activity" RELATED [] +xref: RHEA:32779 +is_a: GO:0015087 ! cobalt ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0032780 +name: negative regulation of ATP-dependent activity +namespace: biological_process +def: "Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah] +synonym: "down regulation of ATPase activity" EXACT [] +synonym: "down-regulation of ATPase activity" EXACT [] +synonym: "downregulation of ATPase activity" EXACT [] +synonym: "inhibition of ATPase activity" NARROW [] +synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] +synonym: "negative regulation of ATPase activity" EXACT [] +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:0044092 ! negative regulation of molecular function + +[Term] +id: GO:0032781 +name: positive regulation of ATP-dependent activity +namespace: biological_process +def: "Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah] +synonym: "activation of ATPase activity" NARROW [] +synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] +synonym: "positive regulation of ATPase activity" EXACT [] +synonym: "stimulation of ATPase activity" NARROW [] +synonym: "up regulation of ATPase activity" EXACT [] +synonym: "up-regulation of ATPase activity" EXACT [] +synonym: "upregulation of ATPase activity" EXACT [] +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:0044093 ! positive regulation of molecular function + +[Term] +id: GO:0032782 +name: bile acid secretion +namespace: biological_process +def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0032783 +name: super elongation complex +namespace: cellular_component +def: "A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae." [PMID:17150956, PMID:30102332] +synonym: "ELL-EAF complex" NARROW [] +synonym: "ELL-EAF-EBP complex" NARROW [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0032784 +name: regulation of DNA-templated transcription, elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] +synonym: "regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] +synonym: "regulation of RNA elongation" BROAD [] +synonym: "regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] +synonym: "regulation of transcriptional elongation" BROAD [] +synonym: "transcription elongation regulator activity" RELATED [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0006354 ! DNA-templated transcription, elongation + +[Term] +id: GO:0032785 +name: negative regulation of DNA-templated transcription, elongation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] +synonym: "down regulation of RNA elongation" BROAD [] +synonym: "down-regulation of RNA elongation" BROAD [] +synonym: "downregulation of RNA elongation" BROAD [] +synonym: "inhibition of RNA elongation" BROAD [] +synonym: "negative regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] +synonym: "negative regulation of transcription elongation" BROAD [] +synonym: "negative regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] +synonym: "negative regulation of transcriptional elongation" BROAD [] +synonym: "negative transcription elongation regulator activity" RELATED [] +is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +relationship: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation + +[Term] +id: GO:0032786 +name: positive regulation of DNA-templated transcription, elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] +synonym: "activation of RNA elongation" BROAD [] +synonym: "positive regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] +synonym: "positive regulation of transcription elongation" BROAD [] +synonym: "positive regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] +synonym: "positive regulation of transcriptional elongation" BROAD [] +synonym: "positive transcription elongation regulator activity" RELATED [] +synonym: "stimulation of RNA elongation" BROAD [] +synonym: "up regulation of RNA elongation" BROAD [] +synonym: "up-regulation of RNA elongation" BROAD [] +synonym: "upregulation of RNA elongation" BROAD [] +is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: positively_regulates GO:0006354 ! DNA-templated transcription, elongation + +[Term] +id: GO:0032787 +name: monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] +subset: goslim_yeast +synonym: "monocarboxylate metabolic process" EXACT [] +synonym: "monocarboxylic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0032788 +name: saturated monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk] +synonym: "saturated monocarboxylate metabolic process" EXACT [] +synonym: "saturated monocarboxylic acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0032789 +name: unsaturated monocarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk] +synonym: "unsaturated monocarboxylate metabolic process" EXACT [] +synonym: "unsaturated monocarboxylic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0032790 +name: ribosome disassembly +namespace: biological_process +def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] +synonym: "ribosome dissociation factor" RELATED [] +synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0032791 +name: lead ion binding +namespace: molecular_function +def: "Binding to lead (Pb) ions." [GOC:mah] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0032792 +name: negative regulation of CREB transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] +synonym: "CREB inhibitor" RELATED [] +synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0032793 +name: positive regulation of CREB transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] +synonym: "activation of CREB" EXACT [] +synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "CREB activator" RELATED [] +is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0032794 +name: GTPase activating protein binding +namespace: molecular_function +def: "Binding to a GTPase activating protein." [GOC:nln] +synonym: "GAP binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0032795 +name: heterotrimeric G-protein binding +namespace: molecular_function +def: "Binding to a heterotrimeric G-protein." [GOC:nln] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0032796 +name: uropod organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] +synonym: "uropod organisation" EXACT [GOC:mah] +synonym: "uropod organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0032797 +name: SMN complex +namespace: cellular_component +def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] +comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. +synonym: "SMN core complex" EXACT [] +synonym: "survival motor neuron complex" EXACT [] +is_a: GO:0120114 ! Sm-like protein family complex +relationship: part_of GO:0034719 ! SMN-Sm protein complex + +[Term] +id: GO:0032798 +name: Swi5-Sfr1 complex +namespace: cellular_component +def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] +comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. +synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw] +synonym: "Swi5 complex" BROAD [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0032799 +name: low-density lipoprotein receptor particle metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk] +synonym: "LDL receptor metabolic process" EXACT [] +synonym: "low-density lipoprotein receptor metabolic process" EXACT [GOC:bf, GOC:dph] +synonym: "low-density lipoprotein receptor metabolism" EXACT [] +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0032800 +name: obsolete receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +comment: The reason for obsoletion is that this represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "receptor anabolism" EXACT [] +synonym: "receptor biosynthesis" EXACT [] +synonym: "receptor formation" EXACT [] +synonym: "receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0032801 +name: receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +synonym: "receptor breakdown" EXACT [] +synonym: "receptor catabolism" EXACT [] +synonym: "receptor degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0043112 ! receptor metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0032802 +name: low-density lipoprotein particle receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] +synonym: "LDL receptor breakdown" EXACT [] +synonym: "LDL receptor catabolic process" EXACT [] +synonym: "LDL receptor catabolism" RELATED [] +synonym: "LDL receptor degradation" EXACT [] +synonym: "low-density lipoprotein receptor breakdown" EXACT [] +synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] +synonym: "low-density lipoprotein receptor catabolism" EXACT [] +synonym: "low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process +is_a: GO:0032801 ! receptor catabolic process +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0032803 +name: regulation of low-density lipoprotein particle receptor catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] +synonym: "regulation of LDLr catabolic process" EXACT [] +synonym: "regulation of LDLr catabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] +synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:1903362 ! regulation of cellular protein catabolic process +is_a: GO:2000644 ! regulation of receptor catabolic process +relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process + +[Term] +id: GO:0032804 +name: negative regulation of low-density lipoprotein particle receptor catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] +synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] +synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT [] +is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process +is_a: GO:1903363 ! negative regulation of cellular protein catabolic process +is_a: GO:2000645 ! negative regulation of receptor catabolic process +relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process + +[Term] +id: GO:0032805 +name: positive regulation of low-density lipoprotein particle receptor catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] +synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] +synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT [] +synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW [] +synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT [] +synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT [] +is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process +is_a: GO:1903364 ! positive regulation of cellular protein catabolic process +is_a: GO:2000646 ! positive regulation of receptor catabolic process +relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process + +[Term] +id: GO:0032806 +name: carboxy-terminal domain protein kinase complex +namespace: cellular_component +def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] +synonym: "CTDK complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0032807 +name: DNA ligase IV complex +namespace: cellular_component +def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] +synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0032808 +name: lacrimal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035272 ! exocrine system development + +[Term] +id: GO:0032809 +name: neuronal cell body membrane +namespace: cellular_component +def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl] +synonym: "neuron cell body membrane" EXACT [] +synonym: "neuronal cell soma membrane" EXACT [] +is_a: GO:0044298 ! cell body membrane +relationship: part_of GO:0043025 ! neuronal cell body + +[Term] +id: GO:0032810 +name: sterol response element binding +namespace: molecular_function +def: "Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] +synonym: "SRE binding" EXACT [] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0032811 +name: negative regulation of epinephrine secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] +synonym: "down regulation of epinephrine secretion" EXACT [] +synonym: "down-regulation of epinephrine secretion" EXACT [] +synonym: "downregulation of epinephrine secretion" EXACT [] +synonym: "inhibition of epinephrine secretion" NARROW [] +synonym: "negative regulation of adrenaline secretion" EXACT [] +is_a: GO:0014060 ! regulation of epinephrine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +relationship: negatively_regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0032812 +name: positive regulation of epinephrine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] +synonym: "activation of epinephrine secretion" NARROW [] +synonym: "positive regulation of adrenaline secretion" EXACT [] +synonym: "stimulation of epinephrine secretion" NARROW [] +synonym: "up regulation of epinephrine secretion" EXACT [] +synonym: "up-regulation of epinephrine secretion" EXACT [] +synonym: "upregulation of epinephrine secretion" EXACT [] +is_a: GO:0014060 ! regulation of epinephrine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +relationship: positively_regulates GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0032813 +name: tumor necrosis factor receptor superfamily binding +namespace: molecular_function +def: "Binding to a member of the tumor necrosis factor receptor superfamily." [GOC:add] +synonym: "TNF receptor superfamily binding" EXACT [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0032814 +name: regulation of natural killer cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "regulation of NK cell activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032815 +name: negative regulation of natural killer cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "down regulation of natural killer cell activation" EXACT [] +synonym: "down-regulation of natural killer cell activation" EXACT [] +synonym: "downregulation of natural killer cell activation" EXACT [] +synonym: "inhibition of natural killer cell activation" NARROW [] +synonym: "negative regulation of NK cell activation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032816 +name: positive regulation of natural killer cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] +synonym: "activation of natural killer cell activation" NARROW [] +synonym: "positive regulation of NK cell activation" EXACT [] +synonym: "stimulation of natural killer cell activation" NARROW [] +synonym: "up regulation of natural killer cell activation" EXACT [] +synonym: "up-regulation of natural killer cell activation" EXACT [] +synonym: "upregulation of natural killer cell activation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0030101 ! natural killer cell activation + +[Term] +id: GO:0032817 +name: regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "regulation of NK cell proliferation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +relationship: regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032818 +name: negative regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "down regulation of natural killer cell proliferation" EXACT [] +synonym: "down-regulation of natural killer cell proliferation" EXACT [] +synonym: "downregulation of natural killer cell proliferation" EXACT [] +synonym: "inhibition of natural killer cell proliferation" NARROW [] +synonym: "negative regulation of NK cell proliferation" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032819 +name: positive regulation of natural killer cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] +synonym: "activation of natural killer cell proliferation" NARROW [] +synonym: "positive regulation of NK cell proliferation" EXACT [] +synonym: "stimulation of natural killer cell proliferation" NARROW [] +synonym: "up regulation of natural killer cell proliferation" EXACT [] +synonym: "up-regulation of natural killer cell proliferation" EXACT [] +synonym: "upregulation of natural killer cell proliferation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +relationship: positively_regulates GO:0001787 ! natural killer cell proliferation + +[Term] +id: GO:0032820 +name: regulation of natural killer cell proliferation involved in immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] +synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] +synonym: "regulation of NK cell proliferation during immune response" RELATED [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0032817 ! regulation of natural killer cell proliferation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response + +[Term] +id: GO:0032821 +name: negative regulation of natural killer cell proliferation involved in immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] +synonym: "down regulation of natural killer cell proliferation during immune response" RELATED [] +synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED [] +synonym: "downregulation of natural killer cell proliferation during immune response" RELATED [] +synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] +synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] +synonym: "negative regulation of NK cell proliferation during immune response" RELATED [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0032818 ! negative regulation of natural killer cell proliferation +is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response + +[Term] +id: GO:0032822 +name: positive regulation of natural killer cell proliferation involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] +synonym: "activation of natural killer cell proliferation during immune response" NARROW [] +synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] +synonym: "positive regulation of NK cell proliferation during immune response" RELATED [] +synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] +synonym: "up regulation of natural killer cell proliferation during immune response" RELATED [] +synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED [] +synonym: "upregulation of natural killer cell proliferation during immune response" RELATED [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0032819 ! positive regulation of natural killer cell proliferation +is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response +relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response + +[Term] +id: GO:0032823 +name: regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of natural killer cell development" RELATED [GOC:add] +synonym: "regulation of NK cell differentiation" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0045619 ! regulation of lymphocyte differentiation +relationship: regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032824 +name: negative regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of natural killer cell differentiation" EXACT [] +synonym: "down-regulation of natural killer cell differentiation" EXACT [] +synonym: "downregulation of natural killer cell differentiation" EXACT [] +synonym: "inhibition of natural killer cell differentiation" NARROW [] +synonym: "negative regulation of natural killer cell development" RELATED [GOC:add] +synonym: "negative regulation of NK cell differentiation" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0032823 ! regulation of natural killer cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032825 +name: positive regulation of natural killer cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of natural killer cell differentiation" NARROW [] +synonym: "positive regulation of natural killer cell development" RELATED [GOC:add] +synonym: "positive regulation of NK cell differentiation" EXACT [] +synonym: "stimulation of natural killer cell differentiation" NARROW [] +synonym: "up regulation of natural killer cell differentiation" EXACT [] +synonym: "up-regulation of natural killer cell differentiation" EXACT [] +synonym: "upregulation of natural killer cell differentiation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0032823 ! regulation of natural killer cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +relationship: positively_regulates GO:0001779 ! natural killer cell differentiation + +[Term] +id: GO:0032826 +name: regulation of natural killer cell differentiation involved in immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add] +synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] +synonym: "regulation of NK cell differentiation during immune response" RELATED [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0032823 ! regulation of natural killer cell differentiation +relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response + +[Term] +id: GO:0032827 +name: negative regulation of natural killer cell differentiation involved in immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of natural killer cell differentiation during immune response" RELATED [] +synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED [] +synonym: "downregulation of natural killer cell differentiation during immune response" RELATED [] +synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] +synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add] +synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] +synonym: "negative regulation of NK cell differentiation during immune response" RELATED [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0032824 ! negative regulation of natural killer cell differentiation +is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response + +[Term] +id: GO:0032828 +name: positive regulation of natural killer cell differentiation involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of natural killer cell differentiation during immune response" NARROW [] +synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add] +synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] +synonym: "positive regulation of NK cell differentiation during immune response" RELATED [] +synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] +synonym: "up regulation of natural killer cell differentiation during immune response" RELATED [] +synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED [] +synonym: "upregulation of natural killer cell differentiation during immune response" RELATED [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0032825 ! positive regulation of natural killer cell differentiation +is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response + +[Term] +id: GO:0032829 +name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032830 +name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation +relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032831 +name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] +synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation +relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + +[Term] +id: GO:0032832 +name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] +synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response + +[Term] +id: GO:0032833 +name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] +synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response + +[Term] +id: GO:0032834 +name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] +synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] +synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] +synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation +is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response + +[Term] +id: GO:0032835 +name: glomerulus development +namespace: biological_process +def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10] +synonym: "glomerular development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0032836 +name: glomerular basement membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] +is_a: GO:0030198 ! extracellular matrix organization +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0032835 ! glomerulus development + +[Term] +id: GO:0032837 +name: distributive segregation +namespace: biological_process +def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] +is_a: GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0032838 +name: plasma membrane bounded cell projection cytoplasm +namespace: cellular_component +def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] +is_a: GO:0099568 ! cytoplasmic region +relationship: part_of GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0032839 +name: dendrite cytoplasm +namespace: cellular_component +def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] +synonym: "dendritic cytoplasm" EXACT [] +is_a: GO:0120111 ! neuron projection cytoplasm +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0032840 +name: intramolecular proline-rich ligand binding +namespace: molecular_function +def: "Binding to a proline-rich region within the same polypeptide." [GOC:pf] +synonym: "intramolecular proline-rich region binding" EXACT [] +is_a: GO:0043621 ! protein self-association +is_a: GO:0070064 ! proline-rich region binding + +[Term] +id: GO:0032841 +name: calcitonin binding +namespace: molecular_function +def: "Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] +is_a: GO:0097644 ! calcitonin family binding + +[Term] +id: GO:0032843 +name: hydroperoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833] +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0032847 +name: regulation of cellular pH reduction +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "regulation of cell pH reduction" EXACT [] +synonym: "regulation of cellular acidification" EXACT [] +synonym: "regulation of intracellular acidification" RELATED [] +synonym: "regulation of intracellular pH reduction" EXACT [] +synonym: "regulation of reduction of cellular pH" EXACT [] +synonym: "regulation of reduction of pH in cell" EXACT [] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051453 ! regulation of intracellular pH +relationship: regulates GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0032848 +name: negative regulation of cellular pH reduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "down regulation of cellular pH reduction" EXACT [] +synonym: "down-regulation of cellular pH reduction" EXACT [] +synonym: "downregulation of cellular pH reduction" EXACT [] +synonym: "inhibition of cellular pH reduction" NARROW [] +synonym: "negative regulation of cell pH reduction" EXACT [] +synonym: "negative regulation of cellular acidification" EXACT [] +synonym: "negative regulation of intracellular acidification" RELATED [] +synonym: "negative regulation of intracellular pH reduction" EXACT [] +synonym: "negative regulation of reduction of cellular pH" EXACT [] +synonym: "negative regulation of reduction of pH in cell" EXACT [] +is_a: GO:0032847 ! regulation of cellular pH reduction +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051454 ! intracellular pH elevation +relationship: negatively_regulates GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0032849 +name: positive regulation of cellular pH reduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] +synonym: "activation of cellular pH reduction" NARROW [] +synonym: "positive regulation of cell pH reduction" EXACT [] +synonym: "positive regulation of cellular acidification" EXACT [] +synonym: "positive regulation of intracellular acidification" RELATED [] +synonym: "positive regulation of intracellular pH reduction" EXACT [] +synonym: "positive regulation of reduction of cellular pH" EXACT [] +synonym: "positive regulation of reduction of pH in cell" EXACT [] +synonym: "stimulation of cellular pH reduction" NARROW [] +synonym: "up regulation of cellular pH reduction" EXACT [] +synonym: "up-regulation of cellular pH reduction" EXACT [] +synonym: "upregulation of cellular pH reduction" EXACT [] +is_a: GO:0032847 ! regulation of cellular pH reduction +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0032865 +name: ERMES complex +namespace: cellular_component +def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles." [GOC:mcc, PMID:19556461, PMID:29279306] +synonym: "ER-mitochondria encounter structure" EXACT [] +synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT [] +synonym: "mitochore" EXACT [GOC:mcc] +synonym: "MMM1 complex" EXACT [GOC:mcc] +is_a: GO:0098799 ! outer mitochondrial membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0044233 ! mitochondria-associated endoplasmic reticulum membrane + +[Term] +id: GO:0032866 +name: D-xylose:NADP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173, RHEA:27445] +synonym: "D-xylose reductase activity" BROAD [] +synonym: "xylose reductase activity" BROAD [] +xref: MetaCyc:RXN-8773 +xref: RHEA:27445 +is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity + +[Term] +id: GO:0032867 +name: L-arabinose:NADP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173, RHEA:25229] +synonym: "arabinose reductase activity" BROAD [] +synonym: "arabinose:NADP reductase activity" BROAD [] +xref: KEGG_REACTION:R01759 +xref: MetaCyc:RXN-8772 +xref: RHEA:25229 +xref: SABIO-RK:1858 +is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity + +[Term] +id: GO:0032868 +name: response to insulin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] +synonym: "response to insulin stimulus" EXACT [GOC:dos] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0032869 +name: cellular response to insulin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] +is_a: GO:0032868 ! response to insulin +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0032870 +name: cellular response to hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] +is_a: GO:0009725 ! response to hormone +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0071495 ! cellular response to endogenous stimulus + +[Term] +id: GO:0032871 +name: regulation of karyogamy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] +is_a: GO:1903353 ! regulation of nucleus organization +relationship: regulates GO:0000741 ! karyogamy + +[Term] +id: GO:0032872 +name: regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "regulation of p38 MAPK signaling" EXACT [] +synonym: "regulation of p38 MAPK signalling" EXACT [] +synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0043408 ! regulation of MAPK cascade +is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade +relationship: regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032873 +name: negative regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "down regulation of stress-activated MAPK cascade" EXACT [] +synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] +synonym: "downregulation of stress-activated MAPK cascade" EXACT [] +synonym: "inhibition of stress-activated MAPK cascade" NARROW [] +synonym: "negative regulation of p38 MAPK signaling" EXACT [] +synonym: "negative regulation of p38 MAPK signalling" EXACT [] +synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +is_a: GO:0043409 ! negative regulation of MAPK cascade +is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade +relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032874 +name: positive regulation of stress-activated MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] +synonym: "activation of stress-activated MAPK cascade" NARROW [] +synonym: "positive regulation of p38 MAPK signaling" EXACT [] +synonym: "positive regulation of p38 MAPK signalling" EXACT [] +synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] +synonym: "stimulation of stress-activated MAPK cascade" NARROW [] +synonym: "up regulation of stress-activated MAPK cascade" EXACT [] +synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] +synonym: "upregulation of stress-activated MAPK cascade" EXACT [] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +is_a: GO:0043410 ! positive regulation of MAPK cascade +is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade +relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0032875 +name: regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "regulation of DNA endoreplication" EXACT [] +synonym: "regulation of DNA re-duplication" EXACT [] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032876 +name: negative regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "down regulation of DNA endoreduplication" EXACT [] +synonym: "down-regulation of DNA endoreduplication" EXACT [] +synonym: "downregulation of DNA endoreduplication" EXACT [] +synonym: "inhibition of DNA endoreduplication" NARROW [] +synonym: "negative regulation of DNA endoreplication" EXACT [] +synonym: "negative regulation of DNA re-duplication" EXACT [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0032875 ! regulation of DNA endoreduplication +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032877 +name: positive regulation of DNA endoreduplication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] +synonym: "activation of DNA endoreduplication" NARROW [] +synonym: "positive regulation of DNA endoreplication" EXACT [] +synonym: "positive regulation of DNA re-duplication" EXACT [] +synonym: "stimulation of DNA endoreduplication" NARROW [] +synonym: "up regulation of DNA endoreduplication" EXACT [] +synonym: "up-regulation of DNA endoreduplication" EXACT [] +synonym: "upregulation of DNA endoreduplication" EXACT [] +is_a: GO:0032875 ! regulation of DNA endoreduplication +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication +relationship: positively_regulates GO:0042023 ! DNA endoreduplication + +[Term] +id: GO:0032878 +name: regulation of establishment or maintenance of cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0032879 +name: regulation of localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "regulation of localisation" EXACT [GOC:mah] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0051179 ! localization + +[Term] +id: GO:0032880 +name: regulation of protein localization +namespace: biological_process +alt_id: GO:1903827 +def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] +subset: goslim_chembl +synonym: "regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein localization" EXACT [] +synonym: "regulation of protein localisation" EXACT [GOC:mah] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0008104 ! protein localization + +[Term] +id: GO:0032881 +name: regulation of polysaccharide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0032882 +name: regulation of chitin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] +synonym: "regulation of chitin metabolism" EXACT [] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0006030 ! chitin metabolic process + +[Term] +id: GO:0032883 +name: regulation of chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah] +synonym: "regulation of chitin anabolism" EXACT [] +synonym: "regulation of chitin biosynthesis" RELATED [] +synonym: "regulation of chitin formation" EXACT [] +synonym: "regulation of chitin synthesis" EXACT [] +is_a: GO:0032882 ! regulation of chitin metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +relationship: regulates GO:0006031 ! chitin biosynthetic process + +[Term] +id: GO:0032884 +name: regulation of cell wall chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah] +synonym: "regulation of cell wall chitin anabolism" EXACT [] +synonym: "regulation of cell wall chitin biosynthesis" EXACT [] +synonym: "regulation of cell wall chitin formation" EXACT [] +synonym: "regulation of cell wall chitin synthesis" EXACT [] +is_a: GO:0032883 ! regulation of chitin biosynthetic process +is_a: GO:0034222 ! regulation of cell wall chitin metabolic process +relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process + +[Term] +id: GO:0032885 +name: regulation of polysaccharide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0000271 ! polysaccharide biosynthetic process + +[Term] +id: GO:0032886 +name: regulation of microtubule-based process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007017 ! microtubule-based process + +[Term] +id: GO:0032887 +name: regulation of spindle elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +relationship: regulates GO:0051231 ! spindle elongation + +[Term] +id: GO:0032888 +name: regulation of mitotic spindle elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] +is_a: GO:0032887 ! regulation of spindle elongation +relationship: part_of GO:0033047 ! regulation of mitotic sister chromatid segregation +relationship: regulates GO:0000022 ! mitotic spindle elongation + +[Term] +id: GO:0032889 +name: regulation of vacuole fusion, non-autophagic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah] +is_a: GO:0044088 ! regulation of vacuole organization +relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic + +[Term] +id: GO:0032890 +name: regulation of organic acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032891 +name: negative regulation of organic acid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of organic acid transport" EXACT [] +synonym: "down-regulation of organic acid transport" EXACT [] +synonym: "downregulation of organic acid transport" EXACT [] +synonym: "inhibition of organic acid transport" NARROW [] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032892 +name: positive regulation of organic acid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of organic acid transport" NARROW [] +synonym: "stimulation of organic acid transport" NARROW [] +synonym: "up regulation of organic acid transport" EXACT [] +synonym: "up-regulation of organic acid transport" EXACT [] +synonym: "upregulation of organic acid transport" EXACT [] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0015849 ! organic acid transport + +[Term] +id: GO:0032896 +name: palmitoyl-CoA 9-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv, PMID:16443825] +synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0032897 +name: negative regulation of viral transcription +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah] +synonym: "down regulation of viral transcription" EXACT [] +synonym: "down-regulation of viral transcription" EXACT [] +synonym: "downregulation of viral transcription" EXACT [] +synonym: "inhibition of viral transcription" NARROW [] +is_a: GO:0046782 ! regulation of viral transcription +is_a: GO:0048525 ! negative regulation of viral process +relationship: negatively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0032898 +name: neurotrophin production +namespace: biological_process +def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0032899 +name: regulation of neurotrophin production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032900 +name: negative regulation of neurotrophin production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +synonym: "down regulation of neurotrophin production" EXACT [] +synonym: "down-regulation of neurotrophin production" EXACT [] +synonym: "downregulation of neurotrophin production" EXACT [] +synonym: "inhibition of neurotrophin production" NARROW [] +is_a: GO:0032899 ! regulation of neurotrophin production +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032901 +name: positive regulation of neurotrophin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] +synonym: "activation of neurotrophin production" NARROW [] +synonym: "stimulation of neurotrophin production" NARROW [] +synonym: "up regulation of neurotrophin production" EXACT [] +synonym: "up-regulation of neurotrophin production" EXACT [] +synonym: "upregulation of neurotrophin production" EXACT [] +is_a: GO:0032899 ! regulation of neurotrophin production +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032902 +name: nerve growth factor production +namespace: biological_process +def: "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah] +synonym: "beta-nerve growth factor production" EXACT [PR:000011194] +synonym: "NGF production" EXACT [] +is_a: GO:0032898 ! neurotrophin production + +[Term] +id: GO:0032903 +name: regulation of nerve growth factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] +synonym: "regulation of beta-nerve growth factor production" EXACT [PR:000011194] +synonym: "regulation of NGF production" EXACT [] +is_a: GO:0032899 ! regulation of neurotrophin production +relationship: regulates GO:0032902 ! nerve growth factor production + +[Term] +id: GO:0032904 +name: negative regulation of nerve growth factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] +synonym: "down regulation of nerve growth factor production" EXACT [] +synonym: "down-regulation of nerve growth factor production" EXACT [] +synonym: "downregulation of nerve growth factor production" EXACT [] +synonym: "inhibition of nerve growth factor production" NARROW [] +synonym: "negative regulation of NGF production" EXACT [] +is_a: GO:0032900 ! negative regulation of neurotrophin production +is_a: GO:0032903 ! regulation of nerve growth factor production +relationship: negatively_regulates GO:0032902 ! nerve growth factor production + +[Term] +id: GO:0032905 +name: transforming growth factor beta1 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B1 production" EXACT [] +synonym: "TGFB1 production" EXACT [] +synonym: "transforming growth factor-beta1 production" EXACT [GOC:bf] +is_a: GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0032906 +name: transforming growth factor beta2 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B2 production" EXACT [] +synonym: "TGFB2 production" EXACT [] +synonym: "transforming growth factor-beta2 production" EXACT [GOC:bf] +is_a: GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0032907 +name: transforming growth factor beta3 production +namespace: biological_process +def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +synonym: "TGF-B3 production" EXACT [] +synonym: "TGFB3 production" EXACT [] +synonym: "transforming growth factor-beta3 production" EXACT [GOC:bf] +is_a: GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0032908 +name: regulation of transforming growth factor beta1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "regulation of TGF-B1 production" EXACT [] +synonym: "regulation of TGFB1 production" EXACT [] +synonym: "regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: regulates GO:0032905 ! transforming growth factor beta1 production + +[Term] +id: GO:0032909 +name: regulation of transforming growth factor beta2 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "regulation of TGF-B2 production" EXACT [] +synonym: "regulation of TGFB2 production" EXACT [] +synonym: "regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: regulates GO:0032906 ! transforming growth factor beta2 production + +[Term] +id: GO:0032910 +name: regulation of transforming growth factor beta3 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "regulation of TGF-B3 production" EXACT [] +synonym: "regulation of TGFB3 production" EXACT [] +synonym: "regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: regulates GO:0032907 ! transforming growth factor beta3 production + +[Term] +id: GO:0032911 +name: negative regulation of transforming growth factor beta1 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta1 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta1 production" NARROW [] +synonym: "negative regulation of TGF-B1 production" EXACT [] +synonym: "negative regulation of TGFB1 production" EXACT [] +synonym: "negative regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] +is_a: GO:0032908 ! regulation of transforming growth factor beta1 production +is_a: GO:0071635 ! negative regulation of transforming growth factor beta production +relationship: negatively_regulates GO:0032905 ! transforming growth factor beta1 production + +[Term] +id: GO:0032912 +name: negative regulation of transforming growth factor beta2 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta2 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta2 production" NARROW [] +synonym: "negative regulation of TGF-B2 production" EXACT [] +synonym: "negative regulation of TGFB2 production" EXACT [] +synonym: "negative regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] +is_a: GO:0032909 ! regulation of transforming growth factor beta2 production +is_a: GO:0071635 ! negative regulation of transforming growth factor beta production +relationship: negatively_regulates GO:0032906 ! transforming growth factor beta2 production + +[Term] +id: GO:0032913 +name: negative regulation of transforming growth factor beta3 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "down regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "down-regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "downregulation of transforming growth factor-beta3 production" EXACT [] +synonym: "inhibition of transforming growth factor-beta3 production" NARROW [] +synonym: "negative regulation of TGF-B3 production" EXACT [] +synonym: "negative regulation of TGFB3 production" EXACT [] +synonym: "negative regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] +is_a: GO:0032910 ! regulation of transforming growth factor beta3 production +is_a: GO:0071635 ! negative regulation of transforming growth factor beta production +relationship: negatively_regulates GO:0032907 ! transforming growth factor beta3 production + +[Term] +id: GO:0032914 +name: positive regulation of transforming growth factor beta1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] +synonym: "activation of transforming growth factor-beta1 production" NARROW [GOC:bf] +synonym: "positive regulation of TGF-B1 production" EXACT [] +synonym: "positive regulation of TGFB1 production" EXACT [] +synonym: "stimulation of transforming growth factor-beta1 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta1 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta1 production" EXACT [] +is_a: GO:0032908 ! regulation of transforming growth factor beta1 production +is_a: GO:0071636 ! positive regulation of transforming growth factor beta production +relationship: positively_regulates GO:0032905 ! transforming growth factor beta1 production + +[Term] +id: GO:0032915 +name: positive regulation of transforming growth factor beta2 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] +synonym: "activation of transforming growth factor-beta2 production" NARROW [] +synonym: "positive regulation of TGF-B2 production" EXACT [] +synonym: "positive regulation of TGFB2 production" EXACT [] +synonym: "positive regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] +synonym: "stimulation of transforming growth factor-beta2 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta2 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta2 production" EXACT [] +is_a: GO:0032909 ! regulation of transforming growth factor beta2 production +is_a: GO:0071636 ! positive regulation of transforming growth factor beta production +relationship: positively_regulates GO:0032906 ! transforming growth factor beta2 production + +[Term] +id: GO:0032916 +name: positive regulation of transforming growth factor beta3 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] +synonym: "activation of transforming growth factor-beta3 production" NARROW [] +synonym: "positive regulation of TGF-B3 production" EXACT [] +synonym: "positive regulation of TGFB3 production" EXACT [] +synonym: "positive regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] +synonym: "stimulation of transforming growth factor-beta3 production" NARROW [] +synonym: "up regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "up-regulation of transforming growth factor-beta3 production" EXACT [] +synonym: "upregulation of transforming growth factor-beta3 production" EXACT [] +is_a: GO:0032910 ! regulation of transforming growth factor beta3 production +is_a: GO:0071636 ! positive regulation of transforming growth factor beta production +relationship: positively_regulates GO:0032907 ! transforming growth factor beta3 production + +[Term] +id: GO:0032917 +name: polyamine acetylation +namespace: biological_process +def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0032918 +name: spermidine acetylation +namespace: biological_process +def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0008216 ! spermidine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032919 +name: spermine acetylation +namespace: biological_process +def: "The modification of spermine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0008215 ! spermine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032920 +name: putrescine acetylation +namespace: biological_process +def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg] +is_a: GO:0009445 ! putrescine metabolic process +is_a: GO:0032917 ! polyamine acetylation + +[Term] +id: GO:0032921 +name: sarcosine oxidase complex +namespace: cellular_component +def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0032922 +name: circadian regulation of gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] +synonym: "circadian regulation of protein expression" RELATED [] +synonym: "diurnal variation of gene expression" RELATED [] +synonym: "diurnal variation of protein expression" RELATED [] +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0032923 +name: organic phosphonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] +synonym: "organophosphonate biosynthetic process" RELATED [] +is_a: GO:0019634 ! organic phosphonate metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0032924 +name: activin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] +synonym: "activin receptor signalling pathway" EXACT [] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0032925 +name: regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] +synonym: "regulation of activin receptor signalling pathway" EXACT [] +synonym: "regulation of activin signaling pathway" RELATED [] +synonym: "regulation of activin signalling pathway" RELATED [] +is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032926 +name: negative regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] +synonym: "down regulation of activin receptor signaling pathway" EXACT [] +synonym: "down-regulation of activin receptor signaling pathway" EXACT [] +synonym: "downregulation of activin receptor signaling pathway" EXACT [] +synonym: "inhibition of activin receptor signaling pathway" NARROW [] +synonym: "negative regulation of activin receptor signalling pathway" EXACT [] +synonym: "negative regulation of activin signaling pathway" RELATED [] +synonym: "negative regulation of activin signalling pathway" RELATED [] +is_a: GO:0032925 ! regulation of activin receptor signaling pathway +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032927 +name: positive regulation of activin receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] +synonym: "activation of activin receptor signaling pathway" NARROW [] +synonym: "positive regulation of activin receptor signalling pathway" EXACT [] +synonym: "positive regulation of activin signaling pathway" RELATED [] +synonym: "positive regulation of activin signalling pathway" RELATED [] +synonym: "stimulation of activin receptor signaling pathway" NARROW [] +synonym: "up regulation of activin receptor signaling pathway" EXACT [] +synonym: "up-regulation of activin receptor signaling pathway" EXACT [] +synonym: "upregulation of activin receptor signaling pathway" EXACT [] +is_a: GO:0032925 ! regulation of activin receptor signaling pathway +is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0032928 +name: regulation of superoxide anion generation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb] +is_a: GO:0090322 ! regulation of superoxide metabolic process +relationship: regulates GO:0042554 ! superoxide anion generation + +[Term] +id: GO:0032929 +name: negative regulation of superoxide anion generation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +synonym: "down regulation of superoxide release" EXACT [] +synonym: "down-regulation of superoxide release" EXACT [] +synonym: "downregulation of superoxide release" EXACT [] +synonym: "inhibition of superoxide release" NARROW [] +synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032928 ! regulation of superoxide anion generation +is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process +relationship: negatively_regulates GO:0042554 ! superoxide anion generation + +[Term] +id: GO:0032930 +name: positive regulation of superoxide anion generation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] +synonym: "activation of superoxide release" NARROW [] +synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of superoxide release" NARROW [] +synonym: "up regulation of superoxide release" EXACT [] +synonym: "up-regulation of superoxide release" EXACT [] +synonym: "upregulation of superoxide release" EXACT [] +is_a: GO:0032928 ! regulation of superoxide anion generation +is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process +relationship: positively_regulates GO:0042554 ! superoxide anion generation + +[Term] +id: GO:0032931 +name: histone acetyltransferase activity (H3-K56 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0032932 +name: negative regulation of astral microtubule depolymerization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah] +synonym: "astral microtubule stabilization" EXACT [] +is_a: GO:0007026 ! negative regulation of microtubule depolymerization +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0090224 ! regulation of spindle organization +relationship: negatively_regulates GO:0060172 ! astral microtubule depolymerization + +[Term] +id: GO:0032933 +name: SREBP signaling pathway +namespace: biological_process +alt_id: GO:0006994 +alt_id: GO:0030967 +alt_id: GO:0035104 +def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871] +synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW [] +synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT [] +synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT [] +synonym: "ER to nucleus sterol response pathway" EXACT [] +synonym: "ER-nuclear sterol response pathway" EXACT [] +synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of transcription via sterol regulatory element binding" NARROW [GOC:vw] +synonym: "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW [GOC:vw] +synonym: "SREBP signalling" EXACT [GOC:bf] +synonym: "SREBP target gene transcriptional activation" EXACT [] +synonym: "SREBP-mediated signaling pathway" RELATED [] +synonym: "SREBP-mediated signalling pathway" EXACT [] +synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] +synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD [] +synonym: "sterol response element binding protein signaling pathway" EXACT [GOC:bf] +synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW [] +synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT [] +synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT [] +synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT [] +is_a: GO:0006984 ! ER-nucleus signaling pathway +is_a: GO:0071501 ! cellular response to sterol depletion + +[Term] +id: GO:0032934 +name: sterol binding +namespace: molecular_function +alt_id: GO:0005498 +def: "Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [GOC:mah] +synonym: "sterol carrier activity" RELATED [GOC:mah] +is_a: GO:0005496 ! steroid binding + +[Term] +id: GO:0032935 +name: sterol sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah] +synonym: "sterol-sensing domain" NARROW [] +is_a: GO:0032934 ! sterol binding +is_a: GO:0106254 ! lipid sensor activity + +[Term] +id: GO:0032936 +name: SREBP-SCAP complex +namespace: cellular_component +def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] +synonym: "Sre1-Scp1 complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex + +[Term] +id: GO:0032937 +name: SREBP-SCAP-Insig complex +namespace: cellular_component +def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane." [PMID:12923525] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane + +[Term] +id: GO:0032938 +name: negative regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +is_a: GO:0032057 ! negative regulation of translational initiation in response to stress +is_a: GO:0043556 ! regulation of translation in response to oxidative stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0032939 +name: positive regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +synonym: "activation of translation in response to oxidative stress" NARROW [] +synonym: "stimulation of translation in response to oxidative stress" NARROW [] +synonym: "up regulation of translation in response to oxidative stress" EXACT [] +synonym: "up-regulation of translation in response to oxidative stress" EXACT [] +synonym: "upregulation of translation in response to oxidative stress" EXACT [] +is_a: GO:0032056 ! positive regulation of translation in response to stress +relationship: part_of GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0032940 +name: secretion by cell +namespace: biological_process +def: "The controlled release of a substance by a cell." [GOC:mah] +synonym: "cellular secretion" EXACT [] +xref: Wikipedia:Secretion +is_a: GO:0046903 ! secretion +is_a: GO:0140352 ! export from cell + +[Term] +id: GO:0032941 +name: secretion by tissue +namespace: biological_process +def: "The controlled release of a substance by a tissue." [GOC:mah] +synonym: "expulsion of gland contents" RELATED [GOC:mah] +synonym: "tissue secretion" EXACT [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0032942 +name: inositol tetrakisphosphate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] +synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] +synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0032943 +name: mononuclear cell proliferation +namespace: biological_process +def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] +synonym: "PBMC proliferation" NARROW [] +synonym: "peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0032944 +name: regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "regulation of PBMC proliferation" NARROW [] +synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032945 +name: negative regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "negative regulation of PBMC proliferation" NARROW [] +synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +is_a: GO:0070664 ! negative regulation of leukocyte proliferation +relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032946 +name: positive regulation of mononuclear cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] +synonym: "activation of mononuclear cell proliferation" NARROW [] +synonym: "positive regulation of PBMC proliferation" NARROW [] +synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] +synonym: "stimulation of mononuclear cell proliferation" NARROW [] +synonym: "up regulation of mononuclear cell proliferation" EXACT [] +synonym: "up-regulation of mononuclear cell proliferation" EXACT [] +synonym: "upregulation of mononuclear cell proliferation" EXACT [] +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +is_a: GO:0070665 ! positive regulation of leukocyte proliferation +relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation + +[Term] +id: GO:0032948 +name: regulation of alpha-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah] +synonym: "regulation of alpha-glucan metabolism" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0032949 +name: regulation of alpha-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah] +synonym: "regulation of alpha-glucan anabolism" EXACT [] +synonym: "regulation of alpha-glucan biosynthesis" EXACT [] +synonym: "regulation of alpha-glucan formation" EXACT [] +synonym: "regulation of alpha-glucan synthesis" EXACT [] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0032948 ! regulation of alpha-glucan metabolic process +relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process + +[Term] +id: GO:0032950 +name: regulation of beta-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah] +synonym: "regulation of beta-glucan metabolism" EXACT [] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0032951 +name: regulation of beta-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah] +synonym: "regulation of beta-glucan anabolism" EXACT [] +synonym: "regulation of beta-glucan biosynthesis" EXACT [] +synonym: "regulation of beta-glucan formation" EXACT [] +synonym: "regulation of beta-glucan synthesis" EXACT [] +is_a: GO:0010962 ! regulation of glucan biosynthetic process +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +relationship: regulates GO:0051274 ! beta-glucan biosynthetic process + +[Term] +id: GO:0032952 +name: regulation of (1->3)-beta-D-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans." [GOC:mah] +synonym: "regulation of (1->3)-beta-D-glucan metabolism" EXACT [] +synonym: "regulation of 1,3-beta-D-glucan metabolic process" EXACT [] +synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD [] +synonym: "regulation of 1,3-beta-glucan metabolism" EXACT [] +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +relationship: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process + +[Term] +id: GO:0032953 +name: regulation of (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:mah] +synonym: "regulation of 1,3-beta-glucan anabolism" EXACT [] +synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD [] +synonym: "regulation of 1,3-beta-glucan formation" EXACT [] +synonym: "regulation of 1,3-beta-glucan synthesis" EXACT [] +is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process +is_a: GO:0032952 ! regulation of (1->3)-beta-D-glucan metabolic process +relationship: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0032954 +name: regulation of cytokinetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0032506 ! cytokinetic process + +[Term] +id: GO:0032955 +name: regulation of division septum assembly +namespace: biological_process +alt_id: GO:1901138 +alt_id: GO:1902468 +def: "Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] +synonym: "regulation of division septum formation" EXACT [] +is_a: GO:1901891 ! regulation of cell septum assembly +relationship: regulates GO:0000917 ! division septum assembly + +[Term] +id: GO:0032956 +name: regulation of actin cytoskeleton organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] +synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] +synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0032970 ! regulation of actin filament-based process +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: regulates GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0032957 +name: inositol trisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah] +synonym: "inositol trisphosphate metabolism" EXACT [] +synonym: "IP3 metabolic process" EXACT [] +synonym: "IP3 metabolism" EXACT [] +synonym: "myo-inositol trisphosphate metabolic process" NARROW [] +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0032958 +name: inositol phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah] +synonym: "inositol phosphate anabolism" EXACT [] +synonym: "inositol phosphate biosynthesis" EXACT [] +synonym: "inositol phosphate formation" EXACT [] +synonym: "inositol phosphate synthesis" EXACT [] +synonym: "myo-inositol phosphate biosynthetic process" NARROW [] +is_a: GO:0043647 ! inositol phosphate metabolic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0032959 +name: inositol trisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [GOC:mah] +synonym: "inositol trisphosphate anabolism" EXACT [] +synonym: "inositol trisphosphate biosynthesis" EXACT [] +synonym: "inositol trisphosphate formation" EXACT [] +synonym: "inositol trisphosphate synthesis" EXACT [] +synonym: "IP3 biosynthesis" EXACT [] +synonym: "IP3 biosynthetic process" EXACT [] +synonym: "myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0032957 ! inositol trisphosphate metabolic process +is_a: GO:0032958 ! inositol phosphate biosynthetic process + +[Term] +id: GO:0032960 +name: regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "regulation of inositol trisphosphate formation" EXACT [] +synonym: "regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "regulation of IP3 biosynthesis" EXACT [] +synonym: "regulation of IP3 biosynthetic process" EXACT [] +synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process +relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032961 +name: negative regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "negative regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "negative regulation of inositol trisphosphate formation" EXACT [] +synonym: "negative regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "negative regulation of IP3 biosynthesis" EXACT [] +synonym: "negative regulation of IP3 biosynthetic process" EXACT [] +synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process +is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process +relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032962 +name: positive regulation of inositol trisphosphate biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] +synonym: "positive regulation of inositol trisphosphate anabolism" EXACT [] +synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT [] +synonym: "positive regulation of inositol trisphosphate formation" EXACT [] +synonym: "positive regulation of inositol trisphosphate synthesis" EXACT [] +synonym: "positive regulation of IP3 biosynthesis" EXACT [] +synonym: "positive regulation of IP3 biosynthetic process" EXACT [] +synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW [] +synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] +is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process +is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process +relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process + +[Term] +id: GO:0032963 +name: collagen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] +synonym: "collagen metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0032964 +name: collagen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] +synonym: "collagen anabolism" EXACT [] +synonym: "collagen biosynthesis" EXACT [] +synonym: "collagen formation" EXACT [] +synonym: "collagen synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0032963 ! collagen metabolic process + +[Term] +id: GO:0032965 +name: regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "regulation of collagen anabolism" EXACT [] +synonym: "regulation of collagen biosynthesis" EXACT [] +synonym: "regulation of collagen formation" EXACT [] +synonym: "regulation of collagen synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0010712 ! regulation of collagen metabolic process +relationship: regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032966 +name: negative regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "negative regulation of collagen anabolism" EXACT [] +synonym: "negative regulation of collagen biosynthesis" EXACT [] +synonym: "negative regulation of collagen formation" EXACT [] +synonym: "negative regulation of collagen synthesis" EXACT [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0010713 ! negative regulation of collagen metabolic process +is_a: GO:0032965 ! regulation of collagen biosynthetic process +relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032967 +name: positive regulation of collagen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] +synonym: "positive regulation of collagen anabolism" EXACT [] +synonym: "positive regulation of collagen biosynthesis" EXACT [] +synonym: "positive regulation of collagen formation" EXACT [] +synonym: "positive regulation of collagen synthesis" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0010714 ! positive regulation of collagen metabolic process +is_a: GO:0032965 ! regulation of collagen biosynthetic process +relationship: positively_regulates GO:0032964 ! collagen biosynthetic process + +[Term] +id: GO:0032968 +name: positive regulation of transcription elongation from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:0090040 +def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] +synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] +synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT [] +is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation +is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:0032969 +name: endosomal scaffold complex +namespace: cellular_component +def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910] +synonym: "endosomal adaptor complex" EXACT [GOC:hjd] +synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0031902 ! late endosome membrane + +[Term] +id: GO:0032970 +name: regulation of actin filament-based process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0030029 ! actin filament-based process + +[Term] +id: GO:0032971 +name: regulation of muscle filament sliding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: regulates GO:0030049 ! muscle filament sliding + +[Term] +id: GO:0032972 +name: regulation of muscle filament sliding speed +namespace: biological_process +def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb] +is_a: GO:0032971 ! regulation of muscle filament sliding +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0032973 +name: amino acid export across plasma membrane +namespace: biological_process +alt_id: GO:0044746 +def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] +synonym: "amino acid efflux" EXACT [] +synonym: "amino acid export" BROAD [] +synonym: "amino acid transmembrane export" BROAD [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0032974 +name: amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +synonym: "amino acid efflux from vacuole" EXACT [] +synonym: "vacuolar amino acid export" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0034486 ! vacuolar transmembrane transport + +[Term] +id: GO:0032975 +name: amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +synonym: "vacuolar amino acid import" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0032976 +name: release of matrix enzymes from mitochondria +namespace: biological_process +def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process." [GOC:mah, GOC:mtg_apoptosis, PMID:9843949] +comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified. +synonym: "mAST release from mitochondria" NARROW [] +synonym: "release of aspartate aminotransferase from mitochondria" NARROW [] +is_a: GO:0008637 ! apoptotic mitochondrial changes + +[Term] +id: GO:0032977 +name: membrane insertase activity +namespace: molecular_function +def: "Binds transmembrane domain-containing proteins and mediates their integration into a membrane." [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176] +xref: Reactome:R-HSA-1268025 "SAM50 complex inserts proteins into mitochondrial outer membrane" +xref: Reactome:R-HSA-1299482 "TIMM23 SORT inserts proteins into inner membrane" +xref: Reactome:R-HSA-1307803 "TIMM22 inserts proteins into inner membrane" +is_a: GO:0140597 ! protein carrier chaperone + +[Term] +id: GO:0032978 +name: protein insertion into membrane from inner side +namespace: biological_process +def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843] +synonym: "insertion of proteins into membrane from the inner side" EXACT [] +is_a: GO:0051205 ! protein insertion into membrane + +[Term] +id: GO:0032979 +name: protein insertion into mitochondrial inner membrane from matrix +namespace: biological_process +def: "The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843] +synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT [] +synonym: "protein insertion into mitochondrial inner membrane from matrix side" EXACT [] +synonym: "protein insertion into mitochondrial membrane from inner side" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0032978 ! protein insertion into membrane from inner side +is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane + +[Term] +id: GO:0032980 +name: keratinocyte activation +namespace: biological_process +def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0032981 +name: mitochondrial respiratory chain complex I assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] +synonym: "mitochondrial complex I assembly" EXACT [] +synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT [] +is_a: GO:0010257 ! NADH dehydrogenase complex assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0032982 +name: myosin filament +namespace: cellular_component +def: "A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] +synonym: "myosin thick filament" RELATED [] +synonym: "thick filament" RELATED [] +is_a: GO:0099512 ! supramolecular fiber + +[Term] +id: GO:0032983 +name: kainate selective glutamate receptor complex +namespace: cellular_component +def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795] +is_a: GO:0008328 ! ionotropic glutamate receptor complex +is_a: GO:0034705 ! potassium channel complex +is_a: GO:0034706 ! sodium channel complex + +[Term] +id: GO:0032984 +name: protein-containing complex disassembly +namespace: biological_process +alt_id: GO:0034623 +alt_id: GO:0043241 +alt_id: GO:0043624 +def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] +synonym: "cellular macromolecule complex disassembly" RELATED [] +synonym: "cellular protein complex disassembly" RELATED [] +synonym: "macromolecule complex disassembly" RELATED [] +synonym: "protein complex disassembly" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0032985 +name: protein-carbohydrate complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah] +is_a: GO:0032984 ! protein-containing complex disassembly +is_a: GO:0071823 ! protein-carbohydrate complex subunit organization + +[Term] +id: GO:0032986 +name: protein-DNA complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] +synonym: "DNA-protein complex disassembly" EXACT [GOC:mah] +is_a: GO:0032984 ! protein-containing complex disassembly +is_a: GO:0071824 ! protein-DNA complex subunit organization + +[Term] +id: GO:0032987 +name: protein-lipid complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] +is_a: GO:0032984 ! protein-containing complex disassembly +is_a: GO:0071825 ! protein-lipid complex subunit organization + +[Term] +id: GO:0032988 +name: ribonucleoprotein complex disassembly +namespace: biological_process +def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] +synonym: "protein-RNA complex disassembly" EXACT [] +synonym: "RNA-protein complex disassembly" EXACT [] +synonym: "RNP complex disassembly" EXACT [] +is_a: GO:0032984 ! protein-containing complex disassembly +is_a: GO:0071826 ! ribonucleoprotein complex subunit organization + +[Term] +id: GO:0032989 +name: cellular component morphogenesis +namespace: biological_process +def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] +subset: goslim_pir +synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +is_a: GO:0016043 ! cellular component organization +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0032990 +name: cell part morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah] +is_a: GO:0032989 ! cellular component morphogenesis + +[Term] +id: GO:0032991 +name: protein-containing complex +namespace: cellular_component +alt_id: GO:0043234 +def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] +comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_pir +synonym: "macromolecular complex" EXACT [] +synonym: "macromolecule complex" EXACT [] +synonym: "protein complex" NARROW [] +synonym: "protein containing complex" EXACT [] +synonym: "protein-protein complex" NARROW [] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0032992 +name: protein-carbohydrate complex +namespace: cellular_component +def: "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other." [GOC:mah] +comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0032993 +name: protein-DNA complex +namespace: cellular_component +def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] +comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. +subset: goslim_pir +synonym: "DNA-protein complex" EXACT [GOC:mah] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0032994 +name: protein-lipid complex +namespace: cellular_component +def: "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah] +comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0032995 +name: regulation of fungal-type cell wall biogenesis +namespace: biological_process +def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0032996 +name: Bcl3-Bcl10 complex +namespace: cellular_component +def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0032997 +name: Fc receptor complex +namespace: cellular_component +def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149] +subset: goslim_pir +synonym: "Fc-receptor complex" EXACT [] +synonym: "FcR complex" EXACT [] +synonym: "immunoglobulin receptor complex" BROAD [] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0032998 +name: Fc-epsilon receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149] +synonym: "FceRI complex" EXACT [] +synonym: "IgE receptor complex" BROAD [] +synonym: "immunoglobulin E receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0032999 +name: Fc-alpha receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149, PMID:12524384] +synonym: "FcaRI complex" EXACT [] +synonym: "IgA receptor complex" BROAD [] +synonym: "immunoglobulin A receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033000 +name: Fc-gamma receptor I complex +namespace: cellular_component +def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] +synonym: "FcgRI complex" EXACT [] +synonym: "IgG receptor complex" BROAD [] +synonym: "immunoglobulin G receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033001 +name: Fc-gamma receptor III complex +namespace: cellular_component +def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] +synonym: "FcgRIII complex" EXACT [] +synonym: "IgG receptor complex" BROAD [] +synonym: "immunoglobulin G receptor complex" BROAD [] +is_a: GO:0032997 ! Fc receptor complex + +[Term] +id: GO:0033002 +name: muscle cell proliferation +namespace: biological_process +def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] +synonym: "myocyte proliferation" EXACT [] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0033003 +name: regulation of mast cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033004 +name: negative regulation of mast cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0033003 ! regulation of mast cell activation +relationship: negatively_regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033005 +name: positive regulation of mast cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0033003 ! regulation of mast cell activation +relationship: positively_regulates GO:0045576 ! mast cell activation + +[Term] +id: GO:0033006 +name: regulation of mast cell activation involved in immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] +synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0033003 ! regulation of mast cell activation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002279 ! mast cell activation involved in immune response + +[Term] +id: GO:0033007 +name: negative regulation of mast cell activation involved in immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] +synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0033004 ! negative regulation of mast cell activation +is_a: GO:0033006 ! regulation of mast cell activation involved in immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response + +[Term] +id: GO:0033008 +name: positive regulation of mast cell activation involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] +synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb] +is_a: GO:0033005 ! positive regulation of mast cell activation +is_a: GO:0033006 ! regulation of mast cell activation involved in immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response + +[Term] +id: GO:0033009 +name: nucleomorph +namespace: cellular_component +def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] +xref: Wikipedia:Nucleomorph +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0033010 +name: paranodal junction +namespace: cellular_component +def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] +synonym: "axoglial septate junction" EXACT [MP:0010735] +synonym: "paranodal axoglial junction" EXACT [PMID:18803321] +synonym: "paranodal septate junction" EXACT [MP:0010735] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0033011 +name: perinuclear theca +namespace: cellular_component +def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] +is_a: GO:0005856 ! cytoskeleton +relationship: part_of GO:0048471 ! perinuclear region of cytoplasm + +[Term] +id: GO:0033012 +name: porosome +namespace: cellular_component +def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] +xref: Wikipedia:Porosome +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0033013 +name: tetrapyrrole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] +subset: goslim_pombe +synonym: "tetrapyrrole metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0033014 +name: tetrapyrrole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] +synonym: "tetrapyrrole anabolism" EXACT [] +synonym: "tetrapyrrole biosynthesis" EXACT [] +synonym: "tetrapyrrole formation" EXACT [] +synonym: "tetrapyrrole synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0033015 +name: tetrapyrrole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [GOC:mah] +synonym: "tetrapyrrole breakdown" EXACT [] +synonym: "tetrapyrrole catabolism" EXACT [] +synonym: "tetrapyrrole degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0033013 ! tetrapyrrole metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0033016 +name: rhoptry membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0020008 ! rhoptry + +[Term] +id: GO:0033017 +name: sarcoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] +is_a: GO:0005789 ! endoplasmic reticulum membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0033018 +name: sarcoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0016529 ! sarcoplasmic reticulum + +[Term] +id: GO:0033019 +name: 5-hydroxyvalerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033020 +name: cyclopentanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764] +synonym: "cyclopentanol metabolism" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0033021 +name: cyclopentanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764] +synonym: "cyclopentanol anabolism" EXACT [] +synonym: "cyclopentanol biosynthesis" EXACT [] +synonym: "cyclopentanol formation" EXACT [] +synonym: "cyclopentanol synthesis" EXACT [] +is_a: GO:0033020 ! cyclopentanol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0033022 +name: cyclopentanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764] +synonym: "cyclopentanol breakdown" EXACT [] +synonym: "cyclopentanol catabolism" EXACT [] +synonym: "cyclopentanol degradation" EXACT [] +is_a: GO:0033020 ! cyclopentanol metabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0033023 +name: mast cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] +comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0033024 +name: mast cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130] +synonym: "apoptosis of mast cells" EXACT [] +synonym: "mast cell apoptosis" NARROW [] +is_a: GO:0033028 ! myeloid cell apoptotic process +is_a: GO:0071887 ! leukocyte apoptotic process +relationship: part_of GO:0033023 ! mast cell homeostasis + +[Term] +id: GO:0033025 +name: regulation of mast cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "regulation of mast cell apoptosis" NARROW [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: regulates GO:0033024 ! mast cell apoptotic process + +[Term] +id: GO:0033026 +name: negative regulation of mast cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "down regulation of mast cell apoptosis" EXACT [] +synonym: "down-regulation of mast cell apoptosis" EXACT [] +synonym: "downregulation of mast cell apoptosis" EXACT [] +synonym: "inhibition of mast cell apoptosis" NARROW [] +synonym: "negative regulation of mast cell apoptosis" NARROW [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0033025 ! regulation of mast cell apoptotic process +is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process +is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process +relationship: negatively_regulates GO:0033024 ! mast cell apoptotic process + +[Term] +id: GO:0033027 +name: positive regulation of mast cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "activation of mast cell apoptosis" NARROW [] +synonym: "positive regulation of mast cell apoptosis" NARROW [] +synonym: "stimulation of mast cell apoptosis" NARROW [] +synonym: "up regulation of mast cell apoptosis" EXACT [] +synonym: "up-regulation of mast cell apoptosis" EXACT [] +synonym: "upregulation of mast cell apoptosis" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0033025 ! regulation of mast cell apoptotic process +is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process +is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process +relationship: positively_regulates GO:0033024 ! mast cell apoptotic process + +[Term] +id: GO:0033028 +name: myeloid cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] +synonym: "apoptosis of myeloid cells" EXACT [] +synonym: "myeloid cell apoptosis" NARROW [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0033029 +name: regulation of neutrophil apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "regulation of neutrophil apoptosis" NARROW [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: regulates GO:0001781 ! neutrophil apoptotic process + +[Term] +id: GO:0033030 +name: negative regulation of neutrophil apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "down regulation of neutrophil apoptosis" EXACT [] +synonym: "down-regulation of neutrophil apoptosis" EXACT [] +synonym: "downregulation of neutrophil apoptosis" EXACT [] +synonym: "inhibition of neutrophil apoptosis" NARROW [] +synonym: "negative regulation of neutrophil apoptosis" NARROW [] +is_a: GO:0033029 ! regulation of neutrophil apoptotic process +is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process +is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process +relationship: negatively_regulates GO:0001781 ! neutrophil apoptotic process + +[Term] +id: GO:0033031 +name: positive regulation of neutrophil apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "activation of neutrophil apoptosis" NARROW [] +synonym: "positive regulation of neutrophil apoptosis" NARROW [] +synonym: "stimulation of neutrophil apoptosis" NARROW [] +synonym: "up regulation of neutrophil apoptosis" EXACT [] +synonym: "up-regulation of neutrophil apoptosis" EXACT [] +synonym: "upregulation of neutrophil apoptosis" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0033029 ! regulation of neutrophil apoptotic process +is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process +is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process +relationship: positively_regulates GO:0001781 ! neutrophil apoptotic process + +[Term] +id: GO:0033032 +name: regulation of myeloid cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "regulation of myeloid cell apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0033028 ! myeloid cell apoptotic process + +[Term] +id: GO:0033033 +name: negative regulation of myeloid cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "down regulation of myeloid cell apoptosis" EXACT [] +synonym: "down-regulation of myeloid cell apoptosis" EXACT [] +synonym: "downregulation of myeloid cell apoptosis" EXACT [] +synonym: "inhibition of myeloid cell apoptosis" NARROW [] +synonym: "negative regulation of myeloid cell apoptosis" NARROW [] +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +is_a: GO:0043066 ! negative regulation of apoptotic process +relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process + +[Term] +id: GO:0033034 +name: positive regulation of myeloid cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] +synonym: "activation of myeloid cell apoptosis" NARROW [] +synonym: "positive regulation of myeloid cell apoptosis" NARROW [] +synonym: "stimulation of myeloid cell apoptosis" NARROW [] +synonym: "up regulation of myeloid cell apoptosis" EXACT [] +synonym: "up-regulation of myeloid cell apoptosis" EXACT [] +synonym: "upregulation of myeloid cell apoptosis" EXACT [] +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +is_a: GO:0043065 ! positive regulation of apoptotic process +relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process + +[Term] +id: GO:0033036 +name: macromolecule localization +namespace: biological_process +def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] +subset: goslim_flybase_ribbon +synonym: "macromolecule localisation" EXACT [GOC:mah] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0033037 +name: polysaccharide localization +namespace: biological_process +def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "polysaccharide localisation" EXACT [GOC:mah] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0033038 +name: bitter taste receptor activity +namespace: molecular_function +def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033039 +name: salty taste receptor activity +namespace: molecular_function +def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033040 +name: sour taste receptor activity +namespace: molecular_function +def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033041 +name: sweet taste receptor activity +namespace: molecular_function +def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0033042 +name: umami taste receptor activity +namespace: molecular_function +def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] +is_a: GO:0090681 ! GPCR taste receptor activity + +[Term] +id: GO:0033043 +name: regulation of organelle organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] +subset: goslim_yeast +synonym: "regulation of organelle organisation" EXACT [GOC:mah] +synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006996 ! organelle organization + +[Term] +id: GO:0033044 +name: regulation of chromosome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] +synonym: "regulation of chromosome organisation" EXACT [GOC:mah] +synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0051276 ! chromosome organization + +[Term] +id: GO:0033045 +name: regulation of sister chromatid segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: regulates GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0033046 +name: negative regulation of sister chromatid segregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0033045 ! regulation of sister chromatid segregation +is_a: GO:0051985 ! negative regulation of chromosome segregation +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0000819 ! sister chromatid segregation + +[Term] +id: GO:0033047 +name: regulation of mitotic sister chromatid segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] +is_a: GO:0033045 ! regulation of sister chromatid segregation +relationship: regulates GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0033048 +name: negative regulation of mitotic sister chromatid segregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] +is_a: GO:0033046 ! negative regulation of sister chromatid segregation +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0033049 +name: clavulanic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah] +synonym: "clavulanic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0033050 +name: clavulanic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [GOC:mah] +synonym: "clavulanic acid anabolism" EXACT [] +synonym: "clavulanic acid biosynthesis" EXACT [] +synonym: "clavulanic acid formation" EXACT [] +synonym: "clavulanic acid synthesis" EXACT [] +xref: Wikipedia:Clavulanic_acid +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0033049 ! clavulanic acid metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0033051 +name: aminophosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah] +synonym: "aminophosphonate metabolism" EXACT [] +xref: KEGG_PATHWAY:map00440 +is_a: GO:0019634 ! organic phosphonate metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0033052 +name: cyanoamino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729] +synonym: "cyanoamino acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0033053 +name: D-glutamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [GOC:jsg, GOC:mah] +synonym: "D-glutamine metabolism" EXACT [] +is_a: GO:0006541 ! glutamine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033054 +name: D-glutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [GOC:jsg, GOC:mah] +synonym: "D-glutamate metabolism" EXACT [] +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033055 +name: D-arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [GOC:jsg, GOC:mah] +synonym: "D-arginine metabolism" EXACT [] +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033056 +name: D-ornithine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [GOC:jsg, GOC:mah] +synonym: "D-ornithine metabolism" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0033058 +name: directional locomotion +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07] +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0033059 +name: cellular pigmentation +namespace: biological_process +def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] +is_a: GO:0009987 ! cellular process +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0033060 +name: ocellus pigmentation +namespace: biological_process +def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07] +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0033061 +name: DNA recombinase mediator complex +namespace: cellular_component +def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992, PMID:32414915] +comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly. +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0033062 +name: Rhp55-Rhp57 complex +namespace: cellular_component +def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] +synonym: "Rad55-Rad57 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033063 +name: Rad51B-Rad51C-Rad51D-XRCC2 complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "BCDX2 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033064 +name: XRCC2-RAD51D complex +namespace: cellular_component +def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] +synonym: "DX2 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033065 +name: Rad51C-XRCC3 complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "CX3 complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033066 +name: Rad51B-Rad51C complex +namespace: cellular_component +def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] +synonym: "BC complex" EXACT [] +is_a: GO:0033061 ! DNA recombinase mediator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033067 +name: macrolide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] +synonym: "macrolide metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:0033068 +name: macrolide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] +synonym: "macrolide anabolism" EXACT [] +synonym: "macrolide biosynthesis" EXACT [] +synonym: "macrolide formation" EXACT [] +synonym: "macrolide synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0033067 ! macrolide metabolic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0033069 +name: ansamycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] +synonym: "ansamycin metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0033070 +name: ansamycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] +synonym: "ansamycin anabolism" EXACT [] +synonym: "ansamycin biosynthesis" EXACT [] +synonym: "ansamycin formation" EXACT [] +synonym: "ansamycin synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0033069 ! ansamycin metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0033071 +name: vancomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah] +synonym: "vancomycin metabolism" EXACT [] +is_a: GO:0030650 ! peptide antibiotic metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0033072 +name: vancomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [GOC:mah] +synonym: "vancomycin anabolism" EXACT [] +synonym: "vancomycin biosynthesis" EXACT [] +synonym: "vancomycin formation" EXACT [] +synonym: "vancomycin synthesis" EXACT [] +is_a: GO:0019184 ! nonribosomal peptide biosynthetic process +is_a: GO:0030651 ! peptide antibiotic biosynthetic process +is_a: GO:0033071 ! vancomycin metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0033073 +name: pinene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, PMID:12623076] +synonym: "pinene metabolism" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process + +[Term] +id: GO:0033074 +name: pinene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, PMID:11452597] +synonym: "pinene breakdown" EXACT [] +synonym: "pinene catabolism" EXACT [] +synonym: "pinene degradation" EXACT [] +is_a: GO:0033073 ! pinene metabolic process +is_a: GO:0043694 ! monoterpene catabolic process + +[Term] +id: GO:0033075 +name: isoquinoline alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] +synonym: "ipecac alkaloid biosynthesis" RELATED [] +synonym: "isoquinoline alkaloid anabolism" EXACT [] +synonym: "isoquinoline alkaloid biosynthesis" EXACT [] +synonym: "isoquinoline alkaloid formation" EXACT [] +synonym: "isoquinoline alkaloid synthesis" EXACT [] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0033076 +name: isoquinoline alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] +synonym: "ipecac alkaloid metabolism" RELATED [] +synonym: "isoquinoline alkaloid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0033077 +name: T cell differentiation in thymus +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T cell development in thymus" RELATED [GOC:add] +synonym: "thymic T cell differentiation" EXACT [] +synonym: "thymocyte cell differentiation" EXACT [] +synonym: "thymocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0033078 +name: extrathymic T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "extrathymic T cell development" RELATED [GOC:add] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0033079 +name: immature T cell proliferation +namespace: biological_process +def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149] +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0033080 +name: immature T cell proliferation in thymus +namespace: biological_process +def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149] +synonym: "thymic T cell proliferation" EXACT [] +synonym: "thymocyte cell proliferation" EXACT [] +synonym: "thymocyte proliferation" EXACT [] +is_a: GO:0033079 ! immature T cell proliferation +relationship: part_of GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:0033081 +name: regulation of T cell differentiation in thymus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of T cell development in thymus" RELATED [GOC:add] +synonym: "regulation of thymic T cell differentiation" EXACT [] +synonym: "regulation of thymocyte cell differentiation" EXACT [] +synonym: "regulation of thymocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:0033082 +name: regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of extrathymic T cell development" RELATED [GOC:add] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033083 +name: regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033084 +name: regulation of immature T cell proliferation in thymus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of thymic T cell proliferation" EXACT [] +synonym: "regulation of thymocyte cell proliferation" EXACT [] +synonym: "regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033083 ! regulation of immature T cell proliferation +relationship: regulates GO:0033080 ! immature T cell proliferation in thymus + +[Term] +id: GO:0033085 +name: negative regulation of T cell differentiation in thymus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add] +synonym: "negative regulation of thymic T cell differentiation" EXACT [] +synonym: "negative regulation of thymocyte cell differentiation" EXACT [] +synonym: "negative regulation of thymocyte differentiation" EXACT [] +is_a: GO:0033081 ! regulation of T cell differentiation in thymus +is_a: GO:0045581 ! negative regulation of T cell differentiation +relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:0033086 +name: negative regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add] +is_a: GO:0033082 ! regulation of extrathymic T cell differentiation +is_a: GO:0045581 ! negative regulation of T cell differentiation +relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033087 +name: negative regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0033083 ! regulation of immature T cell proliferation +is_a: GO:0042130 ! negative regulation of T cell proliferation +relationship: negatively_regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033088 +name: negative regulation of immature T cell proliferation in thymus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +synonym: "negative regulation of thymic T cell proliferation" EXACT [] +synonym: "negative regulation of thymocyte cell proliferation" EXACT [] +synonym: "negative regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus +is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus +is_a: GO:0033087 ! negative regulation of immature T cell proliferation +relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus + +[Term] +id: GO:0033089 +name: positive regulation of T cell differentiation in thymus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add] +synonym: "positive regulation of thymic T cell differentiation" EXACT [] +synonym: "positive regulation of thymocyte cell differentiation" EXACT [] +synonym: "positive regulation of thymocyte differentiation" EXACT [] +is_a: GO:0033081 ! regulation of T cell differentiation in thymus +is_a: GO:0045582 ! positive regulation of T cell differentiation +relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:0033090 +name: positive regulation of extrathymic T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add] +is_a: GO:0033082 ! regulation of extrathymic T cell differentiation +is_a: GO:0045582 ! positive regulation of T cell differentiation +relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0033091 +name: positive regulation of immature T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0033083 ! regulation of immature T cell proliferation +is_a: GO:0042102 ! positive regulation of T cell proliferation +relationship: positively_regulates GO:0033079 ! immature T cell proliferation + +[Term] +id: GO:0033092 +name: positive regulation of immature T cell proliferation in thymus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] +synonym: "positive regulation of thymic T cell proliferation" EXACT [] +synonym: "positive regulation of thymocyte cell proliferation" EXACT [] +synonym: "positive regulation of thymocyte proliferation" EXACT [] +is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus +is_a: GO:0033091 ! positive regulation of immature T cell proliferation +relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus + +[Term] +id: GO:0033093 +name: Weibel-Palade body +namespace: cellular_component +def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] +xref: Wikipedia:Weibel-Palade_body +is_a: GO:0030136 ! clathrin-coated vesicle +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0033094 +name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg, RHEA:12268] +synonym: "PAT activity" RELATED [] +synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82] +synonym: "putrescine transaminase activity" BROAD [] +synonym: "putrescine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.82] +synonym: "putrescine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.82] +synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.82] +synonym: "YgjG" RELATED [EC:2.6.1.82] +xref: EC:2.6.1.82 +xref: MetaCyc:2.6.1.82-RXN +xref: RHEA:12268 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033095 +name: aleurone grain +namespace: cellular_component +def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [PMID:22452734, Wikipedia:Aleurone] +synonym: "aleurone body" EXACT [] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0033096 +name: amyloplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009501 ! amyloplast + +[Term] +id: GO:0033097 +name: amyloplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0033096 ! amyloplast envelope + +[Term] +id: GO:0033098 +name: amyloplast inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0033097 ! amyloplast membrane + +[Term] +id: GO:0033099 +name: attachment organelle +namespace: cellular_component +def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [PMID:11325545, PMID:12003948] +subset: goslim_pir +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0033100 +name: NuA3 histone acetyltransferase complex +namespace: cellular_component +def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] +is_a: GO:0070775 ! H3 histone acetyltransferase complex + +[Term] +id: GO:0033101 +name: cellular bud membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] +synonym: "cellular bud plasma membrane" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0005933 ! cellular bud + +[Term] +id: GO:0033102 +name: acidocalcisome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0020022 ! acidocalcisome + +[Term] +id: GO:0033103 +name: protein secretion by the type VI secretion system +namespace: biological_process +def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. +synonym: "protein secretion by the T6SS" EXACT [] +synonym: "protein secretion by the type VI protein secretion system" EXACT [] +synonym: "type VI protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0033104 +name: type VI protein secretion system complex +namespace: cellular_component +def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] +synonym: "T6SS complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0033105 +name: chlorosome envelope +namespace: cellular_component +def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128] +comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. +synonym: "chlorosome membrane" EXACT [] +is_a: GO:0034646 ! organelle-enclosing lipid monolayer +relationship: part_of GO:0046858 ! chlorosome + +[Term] +id: GO:0033106 +name: cis-Golgi network membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] +synonym: "cis Golgi network membrane" EXACT [] +synonym: "Golgi cis face membrane" RELATED [] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005801 ! cis-Golgi network + +[Term] +id: GO:0033107 +name: Cvt vesicle +namespace: cellular_component +def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] +synonym: "cytoplasm to vacuole targeting vesicle" EXACT [] +synonym: "cytoplasm-to-vacuole targeting vesicle" EXACT [] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0033108 +name: mitochondrial respiratory chain complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0033110 +name: Cvt vesicle membrane +namespace: cellular_component +def: "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway." [GOC:ecd, PMID:20065092] +synonym: "cytoplasm to vacuole targeting vesicle membrane" EXACT [] +synonym: "cytoplasm-to-vacuole targeting vesicle membrane" EXACT [] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0033107 ! Cvt vesicle + +[Term] +id: GO:0033111 +name: attachment organelle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane." [GOC:ecd] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0033099 ! attachment organelle + +[Term] +id: GO:0033112 +name: cyanelle envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0033113 +name: cyanelle membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0033112 ! cyanelle envelope + +[Term] +id: GO:0033114 +name: cyanelle thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] +is_a: GO:0031978 ! plastid thylakoid lumen +relationship: part_of GO:0009843 ! cyanelle thylakoid + +[Term] +id: GO:0033115 +name: cyanelle thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0009843 ! cyanelle thylakoid + +[Term] +id: GO:0033116 +name: endoplasmic reticulum-Golgi intermediate compartment membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730] +synonym: "ER-Golgi intermediate compartment membrane" EXACT [] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment + +[Term] +id: GO:0033117 +name: esterosome +namespace: cellular_component +def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0033118 +name: esterosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0033117 ! esterosome + +[Term] +id: GO:0033119 +name: negative regulation of RNA splicing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0033120 +name: positive regulation of RNA splicing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0033121 +name: regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "regulation of purine nucleotide breakdown" EXACT [] +synonym: "regulation of purine nucleotide catabolism" EXACT [] +synonym: "regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030811 ! regulation of nucleotide catabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +relationship: regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033122 +name: negative regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "negative regulation of purine nucleotide breakdown" EXACT [] +synonym: "negative regulation of purine nucleotide catabolism" EXACT [] +synonym: "negative regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030812 ! negative regulation of nucleotide catabolic process +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033123 +name: positive regulation of purine nucleotide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] +synonym: "positive regulation of purine nucleotide breakdown" EXACT [] +synonym: "positive regulation of purine nucleotide catabolism" EXACT [] +synonym: "positive regulation of purine nucleotide degradation" EXACT [] +is_a: GO:0030813 ! positive regulation of nucleotide catabolic process +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process + +[Term] +id: GO:0033124 +name: obsolete regulation of GTP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "regulation of GTP breakdown" EXACT [] +synonym: "regulation of GTP catabolism" EXACT [] +synonym: "regulation of GTP degradation" EXACT [] +is_obsolete: true +consider: GO:0043087 + +[Term] +id: GO:0033125 +name: obsolete negative regulation of GTP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "negative regulation of GTP breakdown" EXACT [] +synonym: "negative regulation of GTP catabolism" EXACT [] +synonym: "negative regulation of GTP degradation" EXACT [] +is_obsolete: true +consider: GO:0034260 + +[Term] +id: GO:0033126 +name: obsolete positive regulation of GTP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "positive regulation of GTP breakdown" EXACT [] +synonym: "positive regulation of GTP catabolism" EXACT [] +synonym: "positive regulation of GTP degradation" EXACT [] +is_obsolete: true +consider: GO:0043547 + +[Term] +id: GO:0033127 +name: regulation of histone phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0031056 ! regulation of histone modification +relationship: regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033128 +name: negative regulation of histone phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0033127 ! regulation of histone phosphorylation +relationship: negatively_regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033129 +name: positive regulation of histone phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein." [GOC:mah] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0033127 ! regulation of histone phosphorylation +relationship: positively_regulates GO:0016572 ! histone phosphorylation + +[Term] +id: GO:0033130 +name: acetylcholine receptor binding +namespace: molecular_function +def: "Binding to an acetylcholine receptor." [GOC:mah] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0033131 +name: regulation of glucokinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "glucokinase regulator" NARROW [] +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:1903299 ! regulation of hexokinase activity + +[Term] +id: GO:0033132 +name: negative regulation of glucokinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "down regulation of glucokinase activity" EXACT [] +synonym: "down-regulation of glucokinase activity" EXACT [] +synonym: "downregulation of glucokinase activity" EXACT [] +synonym: "glucokinase inhibitor" NARROW [] +synonym: "inhibition of glucokinase activity" NARROW [] +is_a: GO:0033131 ! regulation of glucokinase activity +is_a: GO:1903300 ! negative regulation of hexokinase activity + +[Term] +id: GO:0033133 +name: positive regulation of glucokinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule." [GOC:mah] +synonym: "glucokinase activator" NARROW [] +synonym: "stimulation of glucokinase activity" NARROW [] +synonym: "up regulation of glucokinase activity" EXACT [] +synonym: "up-regulation of glucokinase activity" EXACT [] +synonym: "upregulation of glucokinase activity" EXACT [] +is_a: GO:0033131 ! regulation of glucokinase activity +is_a: GO:1903301 ! positive regulation of hexokinase activity + +[Term] +id: GO:0033134 +name: ubiquitin activating enzyme binding +namespace: molecular_function +def: "Binding to a ubiquitin activating enzyme, any of the E1 proteins." [GOC:mah] +is_a: GO:0044388 ! small protein activating enzyme binding + +[Term] +id: GO:0033135 +name: regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033137 +name: negative regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: negatively_regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033138 +name: positive regulation of peptidyl-serine phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine." [GOC:mah] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: positively_regulates GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0033139 +name: regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:1903261 +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +synonym: "regulation of serine phosphorylation of STAT3 protein" NARROW [] +is_a: GO:0033135 ! regulation of peptidyl-serine phosphorylation +relationship: regulates GO:0042501 ! serine phosphorylation of STAT protein + +[Term] +id: GO:0033140 +name: negative regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:1903262 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +synonym: "down regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "down-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "downregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "inhibition of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "negative regulation of serine phosphorylation of STAT3 protein" NARROW [] +is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation +is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein +relationship: negatively_regulates GO:0042501 ! serine phosphorylation of STAT protein + +[Term] +id: GO:0033141 +name: positive regulation of peptidyl-serine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:1903263 +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:mah] +synonym: "activation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "positive regulation of serine phosphorylation of STAT3 protein" NARROW [] +synonym: "up regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "up-regulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +synonym: "upregulation of serine phosphorylation of STAT3 protein" NARROW [GOC:TermGenie] +is_a: GO:0033138 ! positive regulation of peptidyl-serine phosphorylation +is_a: GO:0033139 ! regulation of peptidyl-serine phosphorylation of STAT protein +relationship: positively_regulates GO:0042501 ! serine phosphorylation of STAT protein + +[Term] +id: GO:0033142 +name: progesterone receptor binding +namespace: molecular_function +def: "Binding to a progesterone receptor." [GOC:mah] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0033143 +name: regulation of intracellular steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] +synonym: "regulation of steroid hormone receptor signalling pathway" BROAD [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0033144 +name: negative regulation of intracellular steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "negative regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] +synonym: "negative regulation of steroid hormone receptor signalling pathway" BROAD [GOC:bf] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +relationship: negatively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0033145 +name: positive regulation of intracellular steroid hormone receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway." [GOC:mah] +synonym: "positive regulation of steroid hormone receptor signaling pathway" BROAD [GOC:bf] +synonym: "positive regulation of steroid hormone receptor signalling pathway" BROAD [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +relationship: positively_regulates GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0033146 +name: regulation of intracellular estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] +synonym: "regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] +synonym: "regulation of estrogen receptor signalling pathway" EXACT [] +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +relationship: regulates GO:0030520 ! intracellular estrogen receptor signaling pathway + +[Term] +id: GO:0033147 +name: negative regulation of intracellular estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] +synonym: "negative regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] +synonym: "negative regulation of estrogen receptor signalling pathway" EXACT [] +is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway +relationship: negatively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway + +[Term] +id: GO:0033148 +name: positive regulation of intracellular estrogen receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway." [GOC:mah] +synonym: "positive regulation of estrogen receptor signaling pathway" BROAD [GOC:bf] +synonym: "positive regulation of estrogen receptor signalling pathway" BROAD [] +is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:0033146 ! regulation of intracellular estrogen receptor signaling pathway +relationship: positively_regulates GO:0030520 ! intracellular estrogen receptor signaling pathway + +[Term] +id: GO:0033149 +name: FFAT motif binding +namespace: molecular_function +def: "Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family." [PMID:12727870, PMID:15455074, PMID:16004875] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0033150 +name: cytoskeletal calyx +namespace: cellular_component +def: "A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins." [PMID:12243744, PMID:9184090] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0033011 ! perinuclear theca + +[Term] +id: GO:0033151 +name: V(D)J recombination +namespace: biological_process +def: "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221, ISBN:0781735149] +synonym: "V(D)J joining" EXACT [] +synonym: "V-D-J joining" EXACT [] +synonym: "V-D-J recombination" EXACT [] +synonym: "V-J joining" EXACT [] +synonym: "V-J recombination" EXACT [] +xref: Wikipedia:V(D)J_recombination +is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus + +[Term] +id: GO:0033152 +name: immunoglobulin V(D)J recombination +namespace: biological_process +def: "The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined." [GOC:add, ISBN:0781735149] +synonym: "immunoglobulin V(D)J joining" EXACT [GOC:add] +synonym: "immunoglobulin V-D-J joining" NARROW [GOC:add] +synonym: "immunoglobulin V-D-J recombination" NARROW [GOC:add] +synonym: "immunoglobulin V-J joining" NARROW [GOC:add] +synonym: "immunoglobulin V-J recombination" NARROW [GOC:add] +is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments +is_a: GO:0033151 ! V(D)J recombination + +[Term] +id: GO:0033153 +name: T cell receptor V(D)J recombination +namespace: biological_process +def: "The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781700221] +synonym: "T cell receptor V(D)J joining" EXACT [GOC:add] +synonym: "T cell receptor V-D-J joining" NARROW [GOC:add] +synonym: "T cell receptor V-D-J recombination" NARROW [GOC:add] +synonym: "T cell receptor V-J joining" NARROW [GOC:add] +synonym: "T cell receptor V-J recombination" NARROW [GOC:add] +synonym: "T-cell receptor V(D)J recombination" EXACT [GOC:add] +synonym: "TCR V(D)J recombination" EXACT [GOC:add] +is_a: GO:0002681 ! somatic recombination of T cell receptor gene segments +is_a: GO:0033151 ! V(D)J recombination + +[Term] +id: GO:0033154 +name: ABC-type oligogalacturonide transporter activity +namespace: molecular_function +alt_id: GO:0033155 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." [GOC:mlg, PMID:11555291, PMID:17451747] +synonym: "ATP-dependent oligogalacturonide transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled oligogalacturonide transmembrane transporter activity" RELATED [] +synonym: "oligogalacturonide transmembrane transporter activity" NARROW [] +synonym: "oligogalacturonide transporting ATPase activity" RELATED [] +synonym: "oligogalacturonide-transporting ATPase activity" EXACT [] +xref: TC:3.A.1.1.11 +is_a: GO:0015422 ! ABC-type oligosaccharide transporter activity + +[Term] +id: GO:0033156 +name: oligogalacturonide transport +namespace: biological_process +def: "The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:0033157 +name: regulation of intracellular protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells." [GOC:mah] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0051223 ! regulation of protein transport +relationship: regulates GO:0006886 ! intracellular protein transport +relationship: regulates GO:0034613 ! cellular protein localization + +[Term] +id: GO:0033158 +name: obsolete regulation of protein import into nucleus, translocation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. +synonym: "regulation of protein import into cell nucleus, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0033159 +name: obsolete negative regulation of protein import into nucleus, translocation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. +synonym: "negative regulation of protein import into cell nucleus, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0033160 +name: obsolete positive regulation of protein import into nucleus, translocation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] +comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. +synonym: "positive regulation of protein import into cell nucleus, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0033161 +name: mitogen-activated protein kinase kinase kinase kinase binding +namespace: molecular_function +def: "Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase." [GOC:mah] +synonym: "MAPKKKK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0033162 +name: melanosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a melanosome." [GOC:mah] +is_a: GO:0090741 ! pigment granule membrane +relationship: part_of GO:0042470 ! melanosome +relationship: part_of GO:0045009 ! chitosome + +[Term] +id: GO:0033163 +name: microneme membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a microneme." [GOC:mah] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0020009 ! microneme + +[Term] +id: GO:0033164 +name: glycolipid 1,6-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage." [GOC:mcc, PMID:16878994] +synonym: "GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232] +synonym: "GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232] +synonym: "GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.232] +synonym: "glycolipid 6-alpha-mannosyltransferase activity" EXACT [] +synonym: "initiation-specific alpha-1,6-mannosyltransferase activity" RELATED [EC:2.4.1.232] +xref: EC:2.4.1.232 +xref: MetaCyc:2.4.1.232-RXN +is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity +is_a: GO:0004376 ! glycolipid mannosyltransferase activity + +[Term] +id: GO:0033165 +name: interphotoreceptor matrix +namespace: cellular_component +def: "A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance." [http://www.glycoforum.gr.jp/science/hyaluronan/HA17/HA17E.html, PMID:1862095, PMID:2194288] +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0033166 +name: hyaline layer +namespace: cellular_component +def: "A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms." [http://worms.zoology.wisc.edu/urchins/SUgast_ECM3.html, PMID:1721506, PMID:9473317] +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0033167 +name: ARC complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA." [GOC:vw, PMID:17310250] +synonym: "argonaute siRNA chaperone complex" EXACT [] +is_a: GO:0031332 ! RNAi effector complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033168 +name: obsolete conversion of ds siRNA to ss siRNA involved in RNA interference +namespace: biological_process +def: "OBSOLETE. The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference." [GOC:mah, PMID:17310250] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "RNA interference, conversion of ds siRNA to ss siRNA" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0004521 +consider: GO:0016246 + +[Term] +id: GO:0033169 +name: histone H3-K9 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone." [GOC:mah] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0033171 +name: obsolete nucleoprotein filament-forming ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the assembly of proteins such as Rad51p onto single-stranded (ss) DNA to form a helical nucleoprotein filament." [GOC:mah, GOC:vw] +comment: This term was made obsolete because nucleoprotein filament formation does not require ATP hydrolysis, so the term is misleading. +synonym: "nucleoprotein filament-forming ATPase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0033172 +name: gas vesicle shell +namespace: cellular_component +def: "The proteinaceous structure surrounding a gas vesicle." [GOC:ecd] +synonym: "gas vesicle membrane" RELATED [] +synonym: "gas vesicle wall" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031411 ! gas vesicle + +[Term] +id: GO:0033173 +name: calcineurin-NFAT signaling cascade +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+)." [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679] +synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf] +synonym: "calcineurin-NFAT signalling pathway" RELATED [] +is_a: GO:0048016 ! inositol phosphate-mediated signaling +is_a: GO:0097720 ! calcineurin-mediated signaling + +[Term] +id: GO:0033174 +name: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) +namespace: cellular_component +def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits." [GOC:mah, GOC:pj, PMID:11032839] +synonym: "chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1)" EXACT [] +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex +relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex + +[Term] +id: GO:0033175 +name: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) +namespace: cellular_component +def: "All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins." [GOC:mah] +synonym: "chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)" EXACT [] +synonym: "chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o)" EXACT [] +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex +relationship: part_of GO:0045320 ! chloroplast proton-transporting ATP synthase complex + +[Term] +id: GO:0033176 +name: proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane." [GOC:mah, ISBN:0716743663, PMID:16449553] +synonym: "hydrogen-translocating V-type ATPase complex" EXACT [] +is_a: GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033177 +name: proton-transporting two-sector ATPase complex, proton-transporting domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins." [GOC:mah, PMID:10838056] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033178 +name: proton-transporting two-sector ATPase complex, catalytic domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled." [GOC:mah, PMID:10838056] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0033179 +name: proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring." [GOC:mah, ISBN:0716743663, PMID:16449553] +is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain +relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex + +[Term] +id: GO:0033180 +name: proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A." [GOC:mah, ISBN:0716743663, PMID:16449553] +is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain +relationship: part_of GO:0033176 ! proton-transporting V-type ATPase complex + +[Term] +id: GO:0033181 +name: plasma membrane proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the plasma membrane." [GOC:mah] +synonym: "plasma membrane hydrogen ion-transporting ATPase" EXACT [] +is_a: GO:0033176 ! proton-transporting V-type ATPase complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0033182 +name: regulation of histone ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0031396 ! regulation of protein ubiquitination +relationship: regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033183 +name: negative regulation of histone ubiquitination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:0033182 ! regulation of histone ubiquitination +relationship: negatively_regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033184 +name: positive regulation of histone ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein." [GOC:mah] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:0033182 ! regulation of histone ubiquitination +relationship: positively_regulates GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033185 +name: dolichol-phosphate-mannose synthase complex +namespace: cellular_component +def: "A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively." [PMID:10835346] +synonym: "dolichyl-phosphate beta-D-mannosyltransferase complex" EXACT [] +synonym: "DPM synthase complex" EXACT [] +is_a: GO:0031501 ! mannosyltransferase complex + +[Term] +id: GO:0033186 +name: CAF-1 complex +namespace: cellular_component +def: "A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48." [PMID:17065558, PMID:17083276] +comment: In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90. +synonym: "chromatin assembly factor 1 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0033187 +name: obsolete inositol hexakisphosphate 4-kinase or 6-kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [PMID:17412958, PMID:17412959] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "inositol hexakisphosphate 4-kinase or 6-kinase activity" EXACT [] +is_obsolete: true +consider: GO:0000830 +consider: GO:0000831 + +[Term] +id: GO:0033188 +name: sphingomyelin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin." [EC:2.7.8.27, RHEA:18765] +synonym: "ceramide:phosphatidylcholine cholinephosphotransferase activity" RELATED [EC:2.7.8.27] +synonym: "phosphatidylcholine:ceramide cholinephosphotransferase activity" RELATED [EC:2.7.8.27] +synonym: "SM synthase activity" RELATED [EC:2.7.8.27] +synonym: "SMS1" RELATED [EC:2.7.8.27] +synonym: "SMS2" RELATED [EC:2.7.8.27] +xref: EC:2.7.8.27 +xref: KEGG_REACTION:R08969 +xref: MetaCyc:2.7.8.27-RXN +xref: Reactome:R-HSA-429786 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]" +xref: Reactome:R-HSA-429798 "phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]" +xref: RHEA:18765 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0033189 +name: response to vitamin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:sl] +synonym: "response to retinol" NARROW [] +is_a: GO:0033273 ! response to vitamin +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0033190 +name: solanapyrone synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A." [GOC:cb, PMID:9659400] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0033191 +name: macrophomate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate." [GOC:cb, PMID:10984474] +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0033192 +name: calmodulin-dependent protein phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:15359118] +synonym: "Ca2+/CaM-dependent protein phosphatase activity" RELATED [] +synonym: "calcineurin activity" NARROW [] +synonym: "calcium- and calmodulin-dependent protein phosphatase activity" EXACT [] +synonym: "calcium/calmodulin-dependent protein phosphatase activity" EXACT [] +xref: Reactome:R-HSA-2730849 "Calcineurin binds and dephosphorylates NFAT" +xref: Reactome:R-HSA-4551451 "Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling" +is_a: GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity + +[Term] +id: GO:0033193 +name: Lsd1/2 complex +namespace: cellular_component +def: "A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast." [GOC:vw, PMID:17371846, PMID:17434129, PMID:17440621] +synonym: "SAPHIRE complex" EXACT [PMID:17371846] +synonym: "Swm complex" EXACT [PMID:17440621] +synonym: "Swm1/2 complex" RELATED [PMID:17440621] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0033194 +name: response to hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033195 +name: response to alkyl hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0033194 ! response to hydroperoxide + +[Term] +id: GO:0033196 +name: tryparedoxin peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O." [GOC:mah] +synonym: "TXNPx activity" EXACT [] +xref: MetaCyc:1.11.1.15-RXN +is_a: GO:0004601 ! peroxidase activity +is_a: GO:0051920 ! peroxiredoxin activity + +[Term] +id: GO:0033197 +name: response to vitamin E +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:sl] +synonym: "response to DL-alpha-tocopherol acetate" NARROW [] +synonym: "response to DL-alpha-tocopheryl acetate" NARROW [] +synonym: "response to O-Acetyl-alpha-tocopherol" NARROW [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033198 +name: response to ATP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:sl] +synonym: "response to adenosine 5'-triphosphate" EXACT [] +synonym: "response to adenosine triphosphate" EXACT [] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033199 +name: obsolete inositol heptakisphosphate 4-kinase or 6-kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "inositol heptakisphosphate 4-kinase or 6-kinase activity" EXACT [] +is_obsolete: true +consider: GO:0000833 +consider: GO:0000834 + +[Term] +id: GO:0033200 +name: inositol heptakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [PMID:17412958] +synonym: "diphosphoinositol-pentakisphosphate 5-kinase activity" EXACT [] +synonym: "IP7 5-kinase activity" EXACT [] +is_a: GO:0000829 ! inositol heptakisphosphate kinase activity + +[Term] +id: GO:0033201 +name: alpha-1,4-glucan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP." [PMID:17472966] +synonym: "1,4-alpha-glucan synthase activity" EXACT [] +xref: EC:2.4.1.21 +xref: RHEA:18189 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0033202 +name: DNA helicase complex +namespace: cellular_component +def: "A protein complex that possesses DNA helicase activity." [GOC:mah] +subset: goslim_metagenomics +subset: goslim_pir +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0033203 +name: DNA helicase A complex +namespace: cellular_component +def: "A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction." [PMID:9341218] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033204 +name: ribonuclease P RNA binding +namespace: molecular_function +def: "Binding to RNA subunit of ribonuclease P." [GOC:pg, PMID:11455963] +synonym: "RNase P RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0033206 +name: meiotic cytokinesis +namespace: biological_process +def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] +synonym: "cytokinesis after meiosis" EXACT [] +is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0033207 +name: beta-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage." [GOC:mah] +synonym: "beta-1,4-GalNAc transferase activity" EXACT [] +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0033208 +name: UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide." [GOC:mah, PMID:12678917, PMID:16024623] +synonym: "Sda beta 1,4GalNAc transferase" RELATED [] +synonym: "UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +is_a: GO:0033207 ! beta-1,4-N-acetylgalactosaminyltransferase activity + +[Term] +id: GO:0033209 +name: tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] +synonym: "adipocytokine signaling pathway" RELATED [] +synonym: "TNF-alpha-mediated signaling pathway" NARROW [] +synonym: "tumor necrosis factor alpha-mediated signaling pathway" NARROW [] +synonym: "tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071356 ! cellular response to tumor necrosis factor + +[Term] +id: GO:0033210 +name: leptin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body." [GOC:mah, GOC:signaling, GOC:yaf] +synonym: "adipocytokine signaling pathway" RELATED [] +synonym: "leptin-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0044320 ! cellular response to leptin stimulus + +[Term] +id: GO:0033211 +name: adiponectin-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:20536390] +synonym: "adipocytokine signaling pathway" RELATED [] +synonym: "adiponectin-mediated signaling pathway" RELATED [] +synonym: "adiponectin-mediated signalling pathway" EXACT [] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0033212 +name: iron import into cell +namespace: biological_process +alt_id: GO:0070627 +def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [PMID:18622392, PMID:23192658, Wikipedia:Human_iron_metabolism] +synonym: "ferrous ion import" NARROW [] +synonym: "ferrous iron import" NARROW [] +synonym: "ferrous iron uptake" NARROW [] +synonym: "iron assimilation" RELATED [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0006879 ! cellular iron ion homeostasis +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0033214 +name: siderophore-dependent iron import into cell +namespace: biological_process +alt_id: GO:0015688 +alt_id: GO:0033213 +def: "A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors." [GOC:mah, PMID:16963626] +synonym: "iron assimilation by capture and transport" RELATED [] +synonym: "iron assimilation by chelation and transport" EXACT [] +synonym: "iron chelate transport" BROAD [] +is_a: GO:0033212 ! iron import into cell +is_a: GO:1901678 ! iron coordination entity transport + +[Term] +id: GO:0033215 +name: reductive iron assimilation +namespace: biological_process +def: "A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins." [GOC:cjm, GOC:mah, PMID:16963626] +synonym: "iron assimilation by reduction and transport" EXACT [] +is_a: GO:0033212 ! iron import into cell + +[Term] +id: GO:0033217 +name: regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:mah] +synonym: "regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [] +is_a: GO:0010106 ! cellular response to iron ion starvation +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0033218 +name: amide binding +namespace: molecular_function +def: "Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:mah] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0033219 +name: urea binding +namespace: molecular_function +def: "Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2." [GOC:mah, ISBN:0198506732] +is_a: GO:0033218 ! amide binding +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0033220 +name: obsolete ATPase-coupled amide-transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + amide(out) = ADP + phosphate + amide(in)." [GOC:mah] +comment: This term was obsoleted because it is an unnecessary grouping class. +synonym: "amide-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent amide-transporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0033221 +name: ATPase-coupled urea transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in)." [GOC:mlg] +synonym: "ATP-dependent urea transmembrane transporter activity" EXACT [] +synonym: "carbamide-transporting ATPase activity" EXACT [] +synonym: "urea-transporting ATPase activity" EXACT [] +xref: RHEA:32803 +is_a: GO:0015204 ! urea transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0033222 +name: xylose binding +namespace: molecular_function +def: "Binding to the D- or L-enantiomer of xylose." [GOC:mah] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0033223 +name: 2-aminoethylphosphonate transport +namespace: biological_process +def: "The directed movement of 2-aminoethylphosphonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] +synonym: "2-phosphonoethylamine transport" EXACT [] +synonym: "ciliatine transport" EXACT [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0033225 +name: ATPase-coupled 2-aminoethylphosphonate transporter activity +namespace: molecular_function +alt_id: GO:0033224 +def: "Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in)." [GOC:mlg] +comment: There is no annotated example of this MF; therefore we cannot classify it more precisely. +synonym: "2-aminoethylphosphonate transmembrane transporter activity" RELATED [] +synonym: "2-aminoethylphosphonate transporting ATPase activity" RELATED [] +synonym: "2-aminoethylphosphonate-transporting ATPase activity" EXACT [] +synonym: "2-phosphonoethylamine transmembrane transporter activity" RELATED [] +synonym: "2-phosphonoethylamine transporting ATPase activity" EXACT [] +synonym: "ATP-dependent 2-aminoethylphosphonate transporter activity" EXACT [] +synonym: "ciliatine transporter activity" RELATED [] +synonym: "ciliatine transportingATPase activity" EXACT [] +xref: RHEA:32775 +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0033226 +name: 2-aminoethylphosphonate binding +namespace: molecular_function +def: "Binding to 2-aminoethylphosphonate." [GOC:mlg] +synonym: "2-phosphonoethylamine binding" EXACT [] +synonym: "ciliatine binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0033227 +name: dsRNA transport +namespace: biological_process +def: "The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0033228 +name: cysteine export across plasma membrane +namespace: biological_process +def: "The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mlg] +synonym: "cysteine export" BROAD [] +is_a: GO:0032973 ! amino acid export across plasma membrane +is_a: GO:1903712 ! cysteine transmembrane transport + +[Term] +id: GO:0033229 +name: cysteine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cysteine from one side of a membrane to the other." [GOC:mah, RHEA:32795] +xref: RHEA:32795 +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity + +[Term] +id: GO:0033230 +name: ABC-type cysteine transporter activity +namespace: molecular_function +alt_id: GO:0032519 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out)." [GOC:mlg, PMID:25837721, PMID:32144203] +synonym: "ATP-dependent cysteine transporter activity" EXACT [] +synonym: "ATPase-coupled cysteine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled cysteine transporter activity" RELATED [] +synonym: "cysteine exporter" RELATED [] +synonym: "cysteine-exporting ATPase activity" RELATED [] +synonym: "cysteine-transporting ATPase activity" EXACT [] +is_a: GO:0015424 ! ABC-type amino acid transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0033229 ! cysteine transmembrane transporter activity + +[Term] +id: GO:0033231 +name: carbohydrate export +namespace: biological_process +def: "The directed movement of carbohydrates out of a cell or organelle." [GOC:mlg] +is_a: GO:0008643 ! carbohydrate transport + +[Term] +id: GO:0033232 +name: ABC-type D-methionine transporter activity +namespace: molecular_function +alt_id: GO:0032521 +alt_id: GO:0032522 +alt_id: GO:0048474 +alt_id: GO:1901243 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out)." [GOC:mlg, PMID:12169620, PMID:12819857, PMID:18621668, RHEA:29779] +synonym: "ATP-dependent D-methionine transporter activity" RELATED [] +synonym: "ATP-dependent methionine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled D-methionine transporter activity" RELATED [] +synonym: "ATPase-coupled methionine transmembrane transporter activity" RELATED [] +synonym: "D-methionine exporter" RELATED [] +synonym: "D-methionine importer" RELATED [] +synonym: "D-methionine transmembrane transporter activity" RELATED [] +synonym: "D-methionine transporter activity" RELATED [] +synonym: "D-methionine-exporting ATPase activity" RELATED [] +synonym: "D-methionine-importing ATPase activity" RELATED [] +synonym: "D-methionine-transporting ATPase activity" RELATED [] +synonym: "methionine transmembrane-transporting ATPase activity" RELATED [] +xref: EC:7.4.2.11 +xref: RHEA:29779 +is_a: GO:0015424 ! ABC-type amino acid transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity +is_a: GO:0043865 ! methionine transmembrane transporter activity + +[Term] +id: GO:0033233 +name: regulation of protein sumoylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] +synonym: "regulation of sumoylation" EXACT [] +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033234 +name: negative regulation of protein sumoylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] +synonym: "negative regulation of sumoylation" EXACT [] +is_a: GO:0033233 ! regulation of protein sumoylation +is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal +relationship: negatively_regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033235 +name: positive regulation of protein sumoylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of SUMO groups to a protein." [GOC:mah] +synonym: "positive regulation of sumoylation" EXACT [] +is_a: GO:0033233 ! regulation of protein sumoylation +is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal +relationship: positively_regulates GO:0016925 ! protein sumoylation + +[Term] +id: GO:0033236 +name: obsolete 11-beta-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036] +synonym: "11-beta-hydroxysteroid dehydrogenase (NAD+) activity" EXACT [] +is_obsolete: true +replaced_by: GO:0070523 + +[Term] +id: GO:0033237 +name: obsolete 11-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [EC:1.1.1.146] +synonym: "11-beta-hydroxysteroid dehydrogenase (NADP+) activity" EXACT [] +synonym: "11beta-hydroxysteroid:NADP+ 11-oxidoreductase" RELATED [EC:1.1.1.146] +synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] +synonym: "corticosteroid 11-beta-dehydrogenase activity" RELATED [EC:1.1.1.146] +is_obsolete: true +replaced_by: GO:0070524 + +[Term] +id: GO:0033238 +name: regulation of cellular amine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines." [GOC:mah] +synonym: "regulation of amine metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0044106 ! cellular amine metabolic process + +[Term] +id: GO:0033239 +name: negative regulation of cellular amine metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] +synonym: "negative regulation of amine metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0044106 ! cellular amine metabolic process + +[Term] +id: GO:0033240 +name: positive regulation of cellular amine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines." [GOC:mah] +synonym: "positive regulation of amine metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0044106 ! cellular amine metabolic process + +[Term] +id: GO:0033241 +name: regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "regulation of amine breakdown" EXACT [] +synonym: "regulation of amine catabolism" EXACT [] +synonym: "regulation of amine degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +relationship: regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033242 +name: negative regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "negative regulation of amine breakdown" EXACT [] +synonym: "negative regulation of amine catabolism" EXACT [] +synonym: "negative regulation of amine degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0033241 ! regulation of cellular amine catabolic process +relationship: negatively_regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033243 +name: positive regulation of cellular amine catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." [GOC:mah] +synonym: "positive regulation of amine breakdown" EXACT [] +synonym: "positive regulation of amine catabolism" EXACT [] +synonym: "positive regulation of amine degradation" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0033241 ! regulation of cellular amine catabolic process +relationship: positively_regulates GO:0009310 ! amine catabolic process + +[Term] +id: GO:0033244 +name: regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "regulation of penicillin metabolism" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033245 +name: negative regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "negative regulation of penicillin metabolism" EXACT [] +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033246 +name: positive regulation of penicillin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "positive regulation of penicillin metabolism" EXACT [] +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:0033247 +name: regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "regulation of penicillin breakdown" EXACT [] +synonym: "regulation of penicillin catabolism" EXACT [] +synonym: "regulation of penicillin degradation" EXACT [] +is_a: GO:0033244 ! regulation of penicillin metabolic process +is_a: GO:0034251 ! regulation of cellular amide catabolic process +relationship: regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033248 +name: negative regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "negative regulation of penicillin breakdown" EXACT [] +synonym: "negative regulation of penicillin catabolism" EXACT [] +synonym: "negative regulation of penicillin degradation" EXACT [] +is_a: GO:0033245 ! negative regulation of penicillin metabolic process +is_a: GO:0033247 ! regulation of penicillin catabolic process +is_a: GO:0034252 ! negative regulation of cellular amide catabolic process +relationship: negatively_regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033249 +name: positive regulation of penicillin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:mah] +synonym: "positive regulation of penicillin breakdown" EXACT [] +synonym: "positive regulation of penicillin catabolism" EXACT [] +synonym: "positive regulation of penicillin degradation" EXACT [] +is_a: GO:0033246 ! positive regulation of penicillin metabolic process +is_a: GO:0033247 ! regulation of penicillin catabolic process +is_a: GO:0034253 ! positive regulation of cellular amide catabolic process +relationship: positively_regulates GO:0042317 ! penicillin catabolic process + +[Term] +id: GO:0033250 +name: penicillinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin." [GOC:mlg] +xref: MetaCyc:BETA-LACTAMASE-RXN +is_a: GO:0008800 ! beta-lactamase activity + +[Term] +id: GO:0033251 +name: cephalosporinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin." [GOC:mlg] +xref: MetaCyc:BETA-LACTAMASE-RXN +is_a: GO:0008800 ! beta-lactamase activity + +[Term] +id: GO:0033252 +name: regulation of beta-lactamase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid." [GOC:mah] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0033253 +name: regulation of penicillinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of a penicillin to yield a substituted beta-amino acid derivative." [GOC:mah] +is_a: GO:0033252 ! regulation of beta-lactamase activity + +[Term] +id: GO:0033254 +name: vacuolar transporter chaperone complex +namespace: cellular_component +def: "A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p." [PMID:11823419, PMID:17079729] +synonym: "VTC complex" EXACT [] +is_a: GO:0101031 ! chaperone complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0033255 +name: SAS acetyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p." [PMID:11731480, PMID:12626510, PMID:15788653] +synonym: "SAS-I complex" EXACT [] +is_a: GO:0032777 ! Piccolo NuA4 histone acetyltransferase complex + +[Term] +id: GO:0033256 +name: I-kappaB/NF-kappaB complex +namespace: cellular_component +def: "A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm." [GOC:bf, GOC:mah, PMID:9407099] +subset: goslim_pir +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0033257 +name: Bcl3/NF-kappaB2 complex +namespace: cellular_component +def: "A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription." [GOC:mah, PMID:9407099] +synonym: "Bcl3-NFKB2 complex" RELATED [] +synonym: "Bcl3-p52 complex" EXACT [] +is_a: GO:0033256 ! I-kappaB/NF-kappaB complex + +[Term] +id: GO:0033258 +name: plastid DNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving plastid DNA." [GOC:mah] +synonym: "plastid DNA metabolism" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0009657 ! plastid organization + +[Term] +id: GO:0033259 +name: plastid DNA replication +namespace: biological_process +def: "The process in which new strands of DNA are synthesized in a plastid." [GOC:mah] +synonym: "plastid DNA synthesis" RELATED [] +synonym: "replication of plastid DNA" EXACT [] +is_a: GO:0006261 ! DNA-dependent DNA replication +is_a: GO:0033258 ! plastid DNA metabolic process + +[Term] +id: GO:0033260 +name: nuclear DNA replication +namespace: biological_process +def: "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] +synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb] +synonym: "DNA replication involved in S phase" EXACT [] +synonym: "DNA replication involved in S-phase" EXACT [] +synonym: "nuclear cell cycle DNA replication" EXACT [] +is_a: GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:0033261 +name: obsolete regulation of S phase +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the rate or extent of the progression through the S phase of the cell cycle." [GOC:dph, GOC:mah, GOC:tb] +comment: This term was made obsolete because cell cycle phases are intervals and so cannot be regulated as such, rather it is the transitions between the phases that are regulated. This term was often also used to annotate genes which should have been annotated to 'regulation of DNA replication', or one of its children. +synonym: "regulation of progression through S phase" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of S phase" EXACT [] +synonym: "regulation of S-phase" EXACT [] +xref: MetaCyc:PWY-5043 +xref: MetaCyc:SALVADEHYPOX-PWY +xref: MetaCyc:SALVPURINE2-PWY +is_obsolete: true +consider: GO:0044770 + +[Term] +id: GO:0033262 +name: regulation of nuclear cell cycle DNA replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] +synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of DNA replication involved in S phase" EXACT [] +synonym: "regulation of DNA replication involved in S-phase" EXACT [] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:0033263 +name: CORVET complex +namespace: cellular_component +def: "A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p." [PMID:17488625] +is_a: GO:0099023 ! vesicle tethering complex +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0033264 +name: obsolete bontoxilysin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "BoNT" RELATED [] +synonym: "bontoxilysin activity" EXACT [] +synonym: "botulinum neurotoxin activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0033265 +name: choline binding +namespace: molecular_function +def: "Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium." [GOC:mlg] +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0033266 +name: ABC-type choline transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane." [GOC:mlg] +synonym: "ABC-type choline transmembrane transporter activity" EXACT [] +synonym: "ATP-dependent choline transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled choline transmembrane transporter activity" RELATED [] +synonym: "choline-transporting ATPase activity" RELATED [] +is_a: GO:0015220 ! choline transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0033267 +name: obsolete axon part +namespace: cellular_component +def: "OBSOLETE. A part of an axon, a cell projection of a neuron." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +xref: NIF_Subcellular:sao280355188 +is_obsolete: true +consider: GO:0030424 + +[Term] +id: GO:0033268 +name: node of Ranvier +namespace: cellular_component +def: "An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed." [GOC:mh] +synonym: "node of Ranvier axon" RELATED [NIF_Subcellular:sao188049490] +xref: NIF_Subcellular:birnlex_1152_2 +xref: Wikipedia:Nodes_of_Ranvier +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0033269 +name: internode region of axon +namespace: cellular_component +def: "An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath." [GOC:mah, GOC:mh] +synonym: "internode" EXACT [] +xref: NIF_Subcellular:sao206157942 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0033270 +name: paranode region of axon +namespace: cellular_component +def: "An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath." [GOC:mah, GOC:mh, NIF_Subcellular:sao936144858] +synonym: "paranode" EXACT [] +xref: NIF_Subcellular:sao234066064 +xref: NIF_Subcellular:sao936144858 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0033271 +name: myo-inositol phosphate transport +namespace: biological_process +def: "The directed movement of any phosphorylated myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:0033272 +name: myo-inositol hexakisphosphate transport +namespace: biological_process +def: "The directed movement of myo-inositol hexakisphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "phytate transport" EXACT [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0033271 ! myo-inositol phosphate transport + +[Term] +id: GO:0033273 +name: response to vitamin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] +is_a: GO:0007584 ! response to nutrient + +[Term] +id: GO:0033274 +name: response to vitamin B2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:sl] +synonym: "response to riboflavin" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033275 +name: actin-myosin filament sliding +namespace: biological_process +def: "The sliding movement of actin thin filaments and myosin thick filaments past each other." [GOC:pf] +synonym: "actin filament sliding" RELATED [] +is_a: GO:0070252 ! actin-mediated cell contraction + +[Term] +id: GO:0033276 +name: transcription factor TFTC complex +namespace: cellular_component +def: "A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity." [PMID:10373431, PMID:9603525] +is_a: GO:0070461 ! SAGA-type complex +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme + +[Term] +id: GO:0033277 +name: abortive mitotic cell cycle +namespace: biological_process +def: "A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy." [GOC:mah, PMID:9573008] +comment: Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms. +synonym: "abortive mitosis" RELATED [] +is_a: GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0033278 +name: cell proliferation in midbrain +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain." [GO_REF:0000021, GOC:dgf] +synonym: "cell proliferation in mesencephalon" EXACT [] +synonym: "mesencepahalic cell proliferation" RELATED [] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:0033280 +name: response to vitamin D +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:sl] +synonym: "response to calciferol" EXACT [] +synonym: "response to cholecalciferol" NARROW [] +synonym: "response to ergocalciferol" NARROW [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033281 +name: TAT protein transport complex +namespace: cellular_component +def: "A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins." [GOC:pamgo_curators] +synonym: "TAT protein secretion complex" NARROW [] +synonym: "TAT protein translocation system complex" NARROW [] +synonym: "Twin-arginine translocation complex" NARROW [] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0033282 +name: protein C inhibitor-acrosin complex +namespace: cellular_component +def: "A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin." [GOC:pr, PMID:11120760, PMID:7521127] +synonym: "PCI-ACR complex" EXACT [PR:000003652, PR:000014685] +synonym: "PCI-acrosin complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-acrosin complex" EXACT [PR:000014685] +synonym: "serpin A5-acrosin complex" EXACT [PR:000014685] +synonym: "SERPINA5-acrosin complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0002080 ! acrosomal membrane + +[Term] +id: GO:0033283 +name: ATPase-coupled organic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." [GOC:mlg] +synonym: "ATP-dependent organic acid transmembrane transporter activity" EXACT [] +synonym: "organic acid-transporting ATPase activity" EXACT [] +is_a: GO:0005342 ! organic acid transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0033284 +name: ATPase-coupled carboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out)." [GOC:mlg] +synonym: "ATP-dependent carboxylic acid transporter activity" EXACT [] +synonym: "carboxylic acid-transporting ATPase activity" EXACT [] +is_a: GO:0033283 ! ATPase-coupled organic acid transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033285 +name: ATPase-coupled monocarboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out)." [GOC:mlg] +synonym: "ATP-dependent monocarboxylic acid transmembrane transporter activity" EXACT [] +synonym: "monocarboxylic acid-transporting ATPase activity" EXACT [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0033284 ! ATPase-coupled carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033286 +name: ATPase-coupled ectoine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0051471 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out)." [GOC:mlg, RHEA:32787] +synonym: "ATP-dependent ectoine transmembrane transporter activity" EXACT [] +synonym: "ectoine transmembrane transporter activity" BROAD [] +synonym: "ectoine-transporting ATPase activity" EXACT [] +xref: RHEA:32787 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033288 +name: ATPase-coupled hydroxyectoine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0033287 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out)." [GOC:mlg] +synonym: "ATP-dependent hydroxyectoine transmembrane transporter activity" EXACT [] +synonym: "hydroxyectoine transmembrane transporter activity" BROAD [] +synonym: "hydroxyectoine-transporting ATPase activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0033285 ! ATPase-coupled monocarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0033289 +name: intraconoid microtubule +namespace: cellular_component +def: "A microtubule located such that it threads through the conoid and projects through the polar ring." [GOC:mah, PMID:11901169, PMID:16518471] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0033290 +name: eukaryotic 48S preinitiation complex +namespace: cellular_component +alt_id: GO:0016283 +def: "A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA." [GOC:hjd, PMID:15145049] +synonym: "eukaryotic 48S initiation complex" RELATED [] +synonym: "eukaryotic 48S pre-initiation complex" EXACT [] +is_a: GO:0070993 ! translation preinitiation complex + +[Term] +id: GO:0033291 +name: eukaryotic 80S initiation complex +namespace: cellular_component +def: "A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region." [GOC:hjd, PMID:15145049] +is_a: GO:0070992 ! translation initiation complex + +[Term] +id: GO:0033292 +name: T-tubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:dph, GOC:jl, GOC:mah] +synonym: "T-tubule organisation" EXACT [GOC:mah] +synonym: "T-tubule organization and biogenesis" RELATED [GOC:mah] +synonym: "transverse tubule organization" EXACT [GOC:rl] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0007009 ! plasma membrane organization +relationship: part_of GO:0055001 ! muscle cell development + +[Term] +id: GO:0033293 +name: monocarboxylic acid binding +namespace: molecular_function +def: "Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0033294 +name: ectoine binding +namespace: molecular_function +def: "Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid." [GOC:mah] +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0033295 +name: hydroxyectoine binding +namespace: molecular_function +def: "Binding to hydroxyectoine." [GOC:mlg] +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0043178 ! alcohol binding +is_a: GO:0050997 ! quaternary ammonium group binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0033296 +name: rhamnose binding +namespace: molecular_function +def: "Binding to the D- or L-enantiomer of rhamnose." [GOC:mah] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0033298 +name: contractile vacuole organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a contractile vacuole. A specialized vacuole that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores." [GOC:mah] +synonym: "contractile vacuole organisation" EXACT [GOC:mah] +synonym: "contractile vacuole organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007033 ! vacuole organization +is_a: GO:0016050 ! vesicle organization + +[Term] +id: GO:0033299 +name: secretion of lysosomal enzymes +namespace: biological_process +def: "The controlled release of lysosomal enzymes by a cell." [GOC:mah] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0033300 +name: dehydroascorbic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other." [GOC:go_curators] +synonym: "dehydroascorbate transporter activity" EXACT [] +synonym: "dehydroascorbic acid transporter activity" RELATED [] +xref: Reactome:R-HSA-198818 "SLC2A1,3 transports DeHA from extracellular region to cytosol" +xref: RHEA:60380 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0033301 +name: cell cycle comprising mitosis without cytokinesis +namespace: biological_process +def: "A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N)." [GOC:expert_vm, GOC:mah] +comment: Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. +is_a: GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0033302 +name: quercetin O-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] +synonym: "quercetin O-glucoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0051552 ! flavone metabolic process + +[Term] +id: GO:0033303 +name: quercetin O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin." [GOC:mah, MetaCyc:PWY-5321] +synonym: "quercetin O-glucoside anabolism" EXACT [] +synonym: "quercetin O-glucoside biosynthesis" EXACT [] +synonym: "quercetin O-glucoside formation" EXACT [] +synonym: "quercetin O-glucoside synthesit" EXACT [] +xref: MetaCyc:PWY-5321 +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0033302 ! quercetin O-glucoside metabolic process +is_a: GO:0051553 ! flavone biosynthetic process + +[Term] +id: GO:0033304 +name: chlorophyll a metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyll a." [GOC:mah] +synonym: "chlorophyll a metabolism" EXACT [] +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0033305 +name: chlorophyll a biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a." [GOC:mah] +synonym: "chlorophyll a anabolism" EXACT [] +synonym: "chlorophyll a biosynthesis" EXACT [] +synonym: "chlorophyll a formation" EXACT [] +synonym: "chlorophyll a synthesis" EXACT [] +is_a: GO:0015995 ! chlorophyll biosynthetic process +is_a: GO:0033304 ! chlorophyll a metabolic process + +[Term] +id: GO:0033306 +name: phytol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah] +synonym: "phytol metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:0033307 +name: phytol salvage +namespace: biological_process +def: "A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis." [GOC:mah, MetaCyc:PWY-5107] +synonym: "phytol salvage pathway" EXACT [] +xref: MetaCyc:PWY-5107 +is_a: GO:0033520 ! phytol biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0033308 +name: hydroxyectoine transport +namespace: biological_process +def: "The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] +is_a: GO:0015697 ! quaternary ammonium group transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0033309 +name: SBF transcription complex +namespace: cellular_component +def: "A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:19150335, PMID:7917338] +synonym: "SBF complex" EXACT [GOC:mah] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0033310 +name: chlorophyll a catabolic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the breakdown of chlorophyll a." [GOC:mah] +synonym: "chlorophyll a breakdown" EXACT [] +synonym: "chlorophyll a catabolism" EXACT [] +synonym: "chlorophyll a degradation" EXACT [] +xref: MetaCyc:PWY-5086 +xref: MetaCyc:PWY-5098 +is_a: GO:0015996 ! chlorophyll catabolic process +is_a: GO:0033304 ! chlorophyll a metabolic process + +[Term] +id: GO:0033311 +name: chlorophyll a biosynthetic process via phytyl diphosphate +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate phytyl diphosphate." [GOC:mah, MetaCyc:PWY-5086] +synonym: "chlorophyll a anabolism via phytyl diphosphate" EXACT [] +synonym: "chlorophyll a biosynthesis via phytyl diphosphate" EXACT [] +synonym: "chlorophyll a biosynthetic process via phytyl-PP" EXACT [] +synonym: "chlorophyll a formation via phytyl chlorophyll a formation via phytyl-PP" EXACT [] +synonym: "chlorophyll a synthesis via phytyl diphosphate" EXACT [] +xref: MetaCyc:PWY-5086 +is_a: GO:0033305 ! chlorophyll a biosynthetic process + +[Term] +id: GO:0033312 +name: chlorophyll a biosynthetic process via geranylgeranyl-chlorophyll a +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of chlorophyll a, via the intermediate geranylgeranyl-chlorophyll a." [GOC:mah, MetaCyc:PWY-5064] +synonym: "chlorophyll a anabolism via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a biosynthesis via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a formation via geranylgeranyl-chlorophyll a" EXACT [] +synonym: "chlorophyll a synthesis via geranylgeranyl-chlorophyll a" EXACT [] +xref: MetaCyc:PWY-5064 +is_a: GO:0033305 ! chlorophyll a biosynthetic process + +[Term] +id: GO:0033313 +name: meiotic cell cycle checkpoint signaling +namespace: biological_process +alt_id: GO:0072411 +def: "A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] +synonym: "meiotic cell cycle checkpoint" EXACT [] +synonym: "signal transduction involved in meiotic cell cycle checkpoint" EXACT [] +is_a: GO:0000075 ! cell cycle checkpoint signaling +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0033314 +name: mitotic DNA replication checkpoint signaling +namespace: biological_process +alt_id: GO:0031574 +alt_id: GO:0072443 +alt_id: GO:0072446 +alt_id: GO:0072459 +def: "A signal transduction process that contributes to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle DNA replication checkpoint" EXACT [] +synonym: "mitotic DNA replication checkpoint" EXACT [] +synonym: "S-M checkpoint" EXACT [] +synonym: "S-M DNA replication checkpoint" EXACT [] +synonym: "S-phase checkpoint" BROAD [] +synonym: "signal transduction involved in mitotic DNA replication checkpoint" NARROW [] +synonym: "signal transduction involved in mitotic G2/M transition decatenation checkpoint" RELATED [] +synonym: "signal transduction involved in S-M checkpoint" EXACT [] +is_a: GO:0000076 ! DNA replication checkpoint signaling +is_a: GO:0044774 ! mitotic DNA integrity checkpoint signaling +is_a: GO:0044818 ! mitotic G2/M transition checkpoint + +[Term] +id: GO:0033315 +name: meiotic G2/MI DNA replication checkpoint signaling +namespace: biological_process +alt_id: GO:0072440 +def: "A signal transduction process that controls the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete." [GOC:mtg_cell_cycle] +synonym: "meiotic cell cycle DNA replication checkpoint" EXACT [] +synonym: "meiotic G2/MI DNA replication checkpoint" EXACT [] +synonym: "signal transduction involved in meiotic DNA replication checkpoint" EXACT [] +is_a: GO:0000076 ! DNA replication checkpoint signaling +is_a: GO:0044778 ! meiotic DNA integrity checkpoint signaling +is_a: GO:0110031 ! negative regulation of G2/MI transition of meiotic cell cycle + +[Term] +id: GO:0033316 +name: meiotic spindle assembly checkpoint signaling +namespace: biological_process +alt_id: GO:0072465 +def: "A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] +synonym: "meiotic spindle assembly checkpoint" EXACT [] +synonym: "signal transduction involved in meiotic spindle assembly checkpoint" EXACT [] +is_a: GO:0044779 ! meiotic spindle checkpoint signaling +is_a: GO:0071173 ! spindle assembly checkpoint signaling + +[Term] +id: GO:0033319 +name: UDP-D-xylose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-xylose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033320 +name: UDP-D-xylose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-xylose, uridinediphosphoxylose, a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-4821] +synonym: "UDP-D-xylose anabolism" EXACT [] +synonym: "UDP-D-xylose biosynthesis" EXACT [] +synonym: "UDP-D-xylose formation" EXACT [] +synonym: "UDP-D-xylose synthesis" EXACT [] +xref: MetaCyc:PWY-4821 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033319 ! UDP-D-xylose metabolic process + +[Term] +id: GO:0033321 +name: homomethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] +synonym: "homomethionine metabolism" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0033322 +name: homomethionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of homomethionine, a non-protein amino acid synthesized from methionine via chain elongation." [GOC:mah, MetaCyc:PWY-1186] +synonym: "homomethionine anabolism" EXACT [] +synonym: "homomethionine biosynthesis" EXACT [] +synonym: "homomethionine formation" EXACT [] +synonym: "homomethionine synthesis" EXACT [] +xref: MetaCyc:PWY-1186 +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0033321 ! homomethionine metabolic process + +[Term] +id: GO:0033323 +name: choline biosynthetic process via CDP-choline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate CDP-choline." [GOC:mah, MetaCyc:PWY-3561] +synonym: "choline anabolism via CDP-choline" EXACT [] +synonym: "choline biosynthesis via CDP-choline" EXACT [] +synonym: "choline formation via CDP-choline" EXACT [] +synonym: "choline synthesis via CDP-choline" EXACT [] +xref: MetaCyc:PWY-3561 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033324 +name: choline biosynthetic process via N-monomethylethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate N-monomethylethanolamine." [GOC:mah, MetaCyc:PWY-3542] +synonym: "choline anabolism via N-monomethylethanolamine" EXACT [] +synonym: "choline biosynthesis via N-monomethylethanolamine" EXACT [] +synonym: "choline formation via N-monomethylethanolamine" EXACT [] +synonym: "choline synthesis via N-monomethylethanolamine" EXACT [] +xref: MetaCyc:PWY-3542 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033325 +name: choline biosynthetic process via phosphoryl-ethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), via the intermediate phosphoryl-ethanolamine." [GOC:mah, MetaCyc:PWY-3385] +synonym: "choline anabolism via phosphoryl-ethanolamine" EXACT [] +synonym: "choline biosynthesis via phosphoryl-ethanolamine" EXACT [] +synonym: "choline formation via phosphoryl-ethanolamine" EXACT [] +synonym: "choline synthesis via phosphoryl-ethanolamine" EXACT [] +xref: MetaCyc:PWY-3385 +xref: MetaCyc:PWY-4762 +is_a: GO:0042425 ! choline biosynthetic process + +[Term] +id: GO:0033326 +name: cerebrospinal fluid secretion +namespace: biological_process +def: "The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces." [GOC:ln, http://users.ahsc.arizona.edu/davis/csf.htm, PMID:10716451] +synonym: "CSF secretion" EXACT [] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0032941 ! secretion by tissue + +[Term] +id: GO:0033327 +name: Leydig cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis." [GOC:ln, PMID:12050120] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0033328 +name: peroxisome membrane targeting sequence binding +namespace: molecular_function +def: "Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane." [GOC:rb, PMID:15133130, PMID:17020786] +synonym: "mPTS binding" EXACT [] +synonym: "peroxisomal membrane protein (PMP) targeting signal (mPTS) binding" EXACT [PMID:14709540] +synonym: "PMP targeting signal (mPTS) binding" EXACT [PMID:14709540] +synonym: "PMP targeting signal binding" EXACT [PMID:14709540] +is_a: GO:0000268 ! peroxisome targeting sequence binding + +[Term] +id: GO:0033329 +name: kaempferol O-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] +synonym: "kaempferol O-glucoside metabolism" EXACT [] +is_a: GO:0051552 ! flavone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:0033330 +name: kaempferol O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol." [GOC:mah, MetaCyc:PWY-5320] +synonym: "kaempferol O-glucoside anabolism" EXACT [] +synonym: "kaempferol O-glucoside biosynthesis" EXACT [] +synonym: "kaempferol O-glucoside formation" EXACT [] +synonym: "kaempferol O-glucoside synthesit" EXACT [] +xref: MetaCyc:PWY-5320 +is_a: GO:0033329 ! kaempferol O-glucoside metabolic process +is_a: GO:0051553 ! flavone biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:0033331 +name: ent-kaurene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] +synonym: "ent-kaurene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0033332 +name: ent-kaurene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ent-kaurene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins." [GOC:mah, MetaCyc:PWY-5032, PMID:17064690] +synonym: "ent-kaurene anabolism" EXACT [] +synonym: "ent-kaurene biosynthesis" EXACT [] +synonym: "ent-kaurene formation" EXACT [] +synonym: "ent-kaurene synthesis" EXACT [] +xref: MetaCyc:PWY-5032 +xref: MetaCyc:PWY-5035 +is_a: GO:0033331 ! ent-kaurene metabolic process +is_a: GO:0046246 ! terpene biosynthetic process + +[Term] +id: GO:0033333 +name: fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0033334 +name: fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a fin are generated and organized." [GOC:dgh] +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0033333 ! fin development + +[Term] +id: GO:0033335 +name: anal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033336 +name: caudal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033337 +name: dorsal fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033338 ! medial fin development + +[Term] +id: GO:0033338 +name: medial fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure." [GOC:dgh] +synonym: "median fin development" EXACT [] +is_a: GO:0033333 ! fin development + +[Term] +id: GO:0033339 +name: pectoral fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033333 ! fin development +is_a: GO:0060173 ! limb development + +[Term] +id: GO:0033340 +name: pelvic fin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0033333 ! fin development +is_a: GO:0060173 ! limb development + +[Term] +id: GO:0033341 +name: regulation of collagen binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collagen binding." [GOC:mah] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0033342 +name: negative regulation of collagen binding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding." [GOC:mah] +synonym: "down regulation of collagen binding" EXACT [] +synonym: "down-regulation of collagen binding" EXACT [] +synonym: "downregulation of collagen binding" EXACT [] +synonym: "inhibition of collagen binding" NARROW [] +is_a: GO:0033341 ! regulation of collagen binding +is_a: GO:0051100 ! negative regulation of binding + +[Term] +id: GO:0033343 +name: positive regulation of collagen binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collagen binding." [GOC:mah] +synonym: "activation of collagen binding" NARROW [] +synonym: "stimulation of collagen binding" NARROW [] +synonym: "up regulation of collagen binding" EXACT [] +synonym: "up-regulation of collagen binding" EXACT [] +synonym: "upregulation of collagen binding" EXACT [] +is_a: GO:0033341 ! regulation of collagen binding +is_a: GO:0051099 ! positive regulation of binding + +[Term] +id: GO:0033344 +name: cholesterol efflux +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:sart] +synonym: "cholesterol export" EXACT [] +is_a: GO:0030301 ! cholesterol transport + +[Term] +id: GO:0033345 +name: asparagine catabolic process via L-aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate." [GOC:mah] +xref: MetaCyc:ASPARAGINE-DEG1-PWY +is_a: GO:0006530 ! asparagine catabolic process + +[Term] +id: GO:0033346 +name: asparagine catabolic process via 2-oxosuccinamate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate." [GOC:mah, MetaCyc:PWY-4002] +xref: MetaCyc:PWY-4002 +is_a: GO:0006530 ! asparagine catabolic process + +[Term] +id: GO:0033347 +name: tetrose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] +synonym: "tetrose metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process + +[Term] +id: GO:0033348 +name: tetrose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a tetrose, any monosaccharide with a chain of four carbon atoms in the molecule." [GOC:mah] +synonym: "tetrose anabolism" EXACT [] +synonym: "tetrose biosynthesis" EXACT [] +synonym: "tetrose formation" EXACT [] +synonym: "tetrose synthesis" EXACT [] +is_a: GO:0033347 ! tetrose metabolic process +is_a: GO:0046364 ! monosaccharide biosynthetic process + +[Term] +id: GO:0033349 +name: apiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah] +synonym: "apiose metabolism" EXACT [] +is_a: GO:0033347 ! tetrose metabolic process + +[Term] +id: GO:0033350 +name: apiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of apiose, the branched tetrose 3-C-(hydroxymethyl)-D-glycero-tetrose." [GOC:mah] +synonym: "apiose anabolism" EXACT [] +synonym: "apiose biosynthesis" EXACT [] +synonym: "apiose formation" EXACT [] +synonym: "apiose synthesis" EXACT [] +is_a: GO:0033348 ! tetrose biosynthetic process +is_a: GO:0033349 ! apiose metabolic process + +[Term] +id: GO:0033351 +name: UDP-D-apiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-apiose, uridinediphosphoapiose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-apiose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033352 +name: UDP-D-apiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-5113] +synonym: "UDP-D-apiose anabolism" EXACT [] +synonym: "UDP-D-apiose biosynthesis" EXACT [] +synonym: "UDP-D-apiose formation" EXACT [] +synonym: "UDP-D-apiose synthesis" EXACT [] +xref: MetaCyc:PWY-4821 +xref: MetaCyc:PWY-5113 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033351 ! UDP-D-apiose metabolic process + +[Term] +id: GO:0033353 +name: S-adenosylmethionine cycle +namespace: biological_process +def: "A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine." [GOC:mah, MetaCyc:PWY-5041] +synonym: "activated methyl cycle" EXACT [] +synonym: "SAM cycle" EXACT [] +xref: MetaCyc:PWY-5041 +is_a: GO:0046500 ! S-adenosylmethionine metabolic process + +[Term] +id: GO:0033354 +name: chlorophyll cycle +namespace: biological_process +def: "A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates." [GOC:mah, MetaCyc:PWY-5068] +xref: MetaCyc:PWY-5068 +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0033355 +name: ascorbate glutathione cycle +namespace: biological_process +def: "A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH." [GOC:mah, MetaCyc:PWY-2261] +synonym: "hydrogen peroxide detoxification" RELATED [] +xref: MetaCyc:PWY-2261 +is_a: GO:0006749 ! glutathione metabolic process +is_a: GO:0019852 ! L-ascorbic acid metabolic process +is_a: GO:0042744 ! hydrogen peroxide catabolic process + +[Term] +id: GO:0033356 +name: UDP-L-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-L-arabinose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033357 +name: L-arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-arabinose, arabino-pentose." [GOC:mah] +synonym: "L-arabinose anabolism" EXACT [] +synonym: "L-arabinose biosynthesis" EXACT [] +synonym: "L-arabinose formation" EXACT [] +synonym: "L-arabinose synthesis" EXACT [] +is_a: GO:0019567 ! arabinose biosynthetic process +is_a: GO:0046373 ! L-arabinose metabolic process + +[Term] +id: GO:0033358 +name: UDP-L-arabinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-L-arabinose, uridinediphosphoarabinose, a substance composed of arabinose in glycosidic linkage with uridine diphosphate." [GOC:mah, MetaCyc:PWY-82] +synonym: "UDP-L-arabinose anabolism" EXACT [] +synonym: "UDP-L-arabinose biosynthesis" EXACT [] +synonym: "UDP-L-arabinose formation" EXACT [] +synonym: "UDP-L-arabinose synthesis" EXACT [] +xref: MetaCyc:PWY-63 +xref: MetaCyc:PWY-82 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033356 ! UDP-L-arabinose metabolic process + +[Term] +id: GO:0033359 +name: lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and N-succinyl-2-amino-6-ketopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:DAPLYSINESYN-PWY-] +synonym: "lysine anabolism via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine formation via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +synonym: "lysine synthesis via diaminopimelate and N-succinyl-2-amino-6-ketopimelate" EXACT [] +xref: MetaCyc:DAPLYSINESYN-PWY +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033360 +name: lysine biosynthetic process via diaminopimelate and L-2-acetamido-6-oxoheptanedioate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediates diaminopimelate and L-2-acetamido-6-oxoheptanedioate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in four enzymatic steps." [GOC:mah, MetaCyc:PWY-2941] +synonym: "lysine anabolism via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine biosynthetic process via diaminopimelic acid and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine formation via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +synonym: "lysine synthesis via diaminopimelate and L-2-acetamido-6-oxoheptanedioate" EXACT [] +xref: MetaCyc:PWY-2941 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033361 +name: lysine biosynthetic process via diaminopimelate, dehydrogenase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step." [GOC:mah, GOC:pr, MetaCyc:PWY-2942] +synonym: "lysine anabolism via diaminopimelate, dehydrogenase pathway" EXACT [] +synonym: "lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway" EXACT [] +synonym: "lysine formation via diaminopimelate, dehydrogenase pathway" EXACT [] +synonym: "lysine synthesis via diaminopimelate, dehydrogenase pathway" EXACT [] +xref: MetaCyc:PWY-2942 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033362 +name: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps." [GOC:mah, GOC:pr, MetaCyc:PWY-5097] +synonym: "lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +synonym: "lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway" EXACT [] +xref: MetaCyc:PWY-5097 +is_a: GO:0009089 ! lysine biosynthetic process via diaminopimelate + +[Term] +id: GO:0033363 +name: secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "secretory granule organisation" EXACT [GOC:mah] +synonym: "secretory granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0033364 +name: mast cell secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "mast cell secretory granule maturation" RELATED [] +synonym: "mast cell secretory granule organisation" EXACT [GOC:mah] +synonym: "mast cell secretory granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0033365 +name: protein localization to organelle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] +synonym: "protein localisation to organelle" EXACT [GOC:mah] +synonym: "protein localization in organelle" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0033366 +name: protein localization to secretory granule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule." [GOC:mah] +synonym: "protein localisation in secretory granule" EXACT [GOC:mah] +synonym: "protein localization in secretory granule" EXACT [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0033367 +name: protein localization to mast cell secretory granule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] +synonym: "protein localisation in mast cell secretory granule" EXACT [GOC:mah] +synonym: "protein localization in mast cell secretory granule" EXACT [] +is_a: GO:0033366 ! protein localization to secretory granule +relationship: part_of GO:0033364 ! mast cell secretory granule organization + +[Term] +id: GO:0033368 +name: protease localization to mast cell secretory granule +namespace: biological_process +def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell." [GOC:mah] +synonym: "protease localisation in mast cell secretory granule" EXACT [GOC:mah] +synonym: "protease localization in mast cell secretory granule" EXACT [] +is_a: GO:0033367 ! protein localization to mast cell secretory granule + +[Term] +id: GO:0033369 +name: establishment of protein localization to mast cell secretory granule +namespace: biological_process +def: "The directed movement of a protein to a location within a secretory granule in a mast cell." [GOC:mah] +synonym: "establishment of protein localisation in mast cell secretory granule" EXACT [GOC:mah] +synonym: "establishment of protein localization in mast cell secretory granule" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule + +[Term] +id: GO:0033370 +name: maintenance of protein location in mast cell secretory granule +namespace: biological_process +def: "A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protein localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "mast cell protein retention" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0033367 ! protein localization to mast cell secretory granule + +[Term] +id: GO:0033371 +name: T cell secretory granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [GOC:mah] +synonym: "T cell secretory granule organisation" EXACT [GOC:mah] +synonym: "T cell secretory granule organization and biogenesis" RELATED [GOC:mah] +synonym: "T lymphocyte secretory granule organization" EXACT [] +synonym: "T-cell secretory granule organization" EXACT [] +synonym: "T-lymphocyte secretory granule maturation" RELATED [] +synonym: "T-lymphocyte secretory granule organization" EXACT [] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0033372 +name: establishment of protease localization to mast cell secretory granule +namespace: biological_process +def: "The directed movement of a protease to a location within a secretory granule in a mast cell." [GOC:mah] +synonym: "establishment of protease localisation in mast cell secretory granule" EXACT [GOC:mah] +synonym: "establishment of protease localization in mast cell secretory granule" EXACT [] +is_a: GO:0033369 ! establishment of protein localization to mast cell secretory granule +relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule + +[Term] +id: GO:0033373 +name: maintenance of protease location in mast cell secretory granule +namespace: biological_process +def: "A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protease localization in mast cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "mast cell protease retention" EXACT [] +is_a: GO:0033370 ! maintenance of protein location in mast cell secretory granule +relationship: part_of GO:0033368 ! protease localization to mast cell secretory granule + +[Term] +id: GO:0033374 +name: protein localization to T cell secretory granule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "protein localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "protein localization in T cell secretory granule" EXACT [] +synonym: "protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "protein localization in T-cell secretory granule" EXACT [] +synonym: "protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033366 ! protein localization to secretory granule +relationship: part_of GO:0033371 ! T cell secretory granule organization + +[Term] +id: GO:0033375 +name: protease localization to T cell secretory granule +namespace: biological_process +def: "Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "protease localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "protease localization in T cell secretory granule" EXACT [] +synonym: "protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "protease localization in T-cell secretory granule" EXACT [] +synonym: "protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033374 ! protein localization to T cell secretory granule + +[Term] +id: GO:0033376 +name: establishment of protein localization to T cell secretory granule +namespace: biological_process +def: "The directed movement of a protein to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of protein localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "establishment of protein localization in T cell secretory granule" EXACT [] +synonym: "establishment of protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of protein localization in T-cell secretory granule" EXACT [] +synonym: "establishment of protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +relationship: part_of GO:0033374 ! protein localization to T cell secretory granule + +[Term] +id: GO:0033377 +name: maintenance of protein location in T cell secretory granule +namespace: biological_process +def: "A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protein localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protein localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of protein localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of protein localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0033374 ! protein localization to T cell secretory granule + +[Term] +id: GO:0033378 +name: establishment of protease localization to T cell secretory granule +namespace: biological_process +def: "The directed movement of a protease to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of protease localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "establishment of protease localization in T cell secretory granule" EXACT [] +synonym: "establishment of protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of protease localization in T-cell secretory granule" EXACT [] +synonym: "establishment of protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033376 ! establishment of protein localization to T cell secretory granule +relationship: part_of GO:0033375 ! protease localization to T cell secretory granule + +[Term] +id: GO:0033379 +name: maintenance of protease location in T cell secretory granule +namespace: biological_process +def: "A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] +synonym: "maintenance of protease localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protease localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of protease localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of protease localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033377 ! maintenance of protein location in T cell secretory granule +relationship: part_of GO:0033375 ! protease localization to T cell secretory granule + +[Term] +id: GO:0033380 +name: granzyme B localization to T cell secretory granule +namespace: biological_process +def: "Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell." [GOC:mah] +synonym: "granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "granzyme B localization in T cell secretory granule" EXACT [] +synonym: "granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "granzyme B localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033375 ! protease localization to T cell secretory granule + +[Term] +id: GO:0033381 +name: establishment of granzyme B localization to T cell secretory granule +namespace: biological_process +def: "The directed movement of the protease granzyme B to a location within a secretory granule in a T cell." [GOC:mah] +synonym: "establishment of granzyme B localisation in T cell secretory granule" EXACT [GOC:mah] +synonym: "establishment of granzyme B localization in T cell secretory granule" EXACT [] +synonym: "establishment of granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "establishment of granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "establishment of granzyme B localization in T-lymphocyte secretory granule" EXACT [] +synonym: "T-lymphocyte secretory granule storage of granzyme B" RELATED [] +is_a: GO:0033378 ! establishment of protease localization to T cell secretory granule +relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule + +[Term] +id: GO:0033382 +name: maintenance of granzyme B location in T cell secretory granule +namespace: biological_process +def: "A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere." [GOC:mah] +synonym: "maintenance of granzyme B localization in T cell secretory granule" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of granzyme B localization in T lymphocyte secretory granule" EXACT [] +synonym: "maintenance of granzyme B localization in T-cell secretory granule" EXACT [] +synonym: "maintenance of granzyme B localization in T-lymphocyte secretory granule" EXACT [] +is_a: GO:0033379 ! maintenance of protease location in T cell secretory granule +relationship: part_of GO:0033380 ! granzyme B localization to T cell secretory granule + +[Term] +id: GO:0033383 +name: geranyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving geranyl diphosphate, the universal precursor of the monoterpenes." [GOC:mah, MetaCyc:PWY-5122] +synonym: "geranyl diphosphate metabolism" EXACT [] +synonym: "geranyldiphosphate metabolic process" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0033384 +name: geranyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of geranyl diphosphate." [GOC:mah, MetaCyc:PWY-5122] +synonym: "geranyl diphosphate anabolism" EXACT [] +synonym: "geranyl diphosphate biosynthesis" EXACT [] +synonym: "geranyl diphosphate formation" EXACT [] +synonym: "geranyl diphosphate synthesis" EXACT [] +synonym: "geranyldiphosphate biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5122 +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0033383 ! geranyl diphosphate metabolic process + +[Term] +id: GO:0033385 +name: geranylgeranyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving geranylgeranyl diphosphate, a polyprenol compound involved in the biosynthesis of a variety of terpenoids including chlorophylls, carotenoids, tocopherols, plastoquinones, and the plant hormones gibberellins." [GOC:mah, MetaCyc:PWY-5120] +synonym: "geranylgeranyl diphosphate metabolism" EXACT [] +synonym: "geranylgeranyldiphosphate metabolic process" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0033386 +name: geranylgeranyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of geranylgeranyl diphosphate." [GOC:mah, MetaCyc:PWY-5120] +synonym: "geranylgeranyl diphosphate anabolism" EXACT [] +synonym: "geranylgeranyl diphosphate biosynthesis" EXACT [] +synonym: "geranylgeranyl diphosphate formation" EXACT [] +synonym: "geranylgeranyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5120 +xref: MetaCyc:PWY-5121 +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process + +[Term] +id: GO:0033387 +name: putrescine biosynthetic process from ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine." [GOC:mah, MetaCyc:PWY-46] +synonym: "putrescine anabolism from ornithine" EXACT [] +synonym: "putrescine biosynthesis from ornithine" EXACT [] +synonym: "putrescine formation from ornithine" EXACT [] +synonym: "putrescine synthesis from ornithine" EXACT [] +is_a: GO:0006591 ! ornithine metabolic process +is_a: GO:0009446 ! putrescine biosynthetic process + +[Term] +id: GO:0033388 +name: putrescine biosynthetic process from arginine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine." [GOC:mah, MetaCyc:PWY-46] +synonym: "putrescine anabolism from arginine" EXACT [] +synonym: "putrescine biosynthesis from arginine" EXACT [] +synonym: "putrescine formation from arginine" EXACT [] +synonym: "putrescine synthesis from arginine" EXACT [] +is_a: GO:0006525 ! arginine metabolic process +is_a: GO:0009446 ! putrescine biosynthetic process + +[Term] +id: GO:0033389 +name: putrescine biosynthetic process from arginine, using agmatinase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in a single enzymatic step." [GOC:mah, MetaCyc:PWY-40] +synonym: "putrescine anabolism from arginine, using agmatinase" EXACT [] +synonym: "putrescine biosynthesis from arginine, using agmatinase" EXACT [] +synonym: "putrescine formation from arginine, using agmatinase" EXACT [] +synonym: "putrescine synthesis from arginine, using agmatinase" EXACT [] +is_a: GO:0033388 ! putrescine biosynthetic process from arginine + +[Term] +id: GO:0033390 +name: putrescine biosynthetic process from arginine via N-carbamoylputrescine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane, from other compounds, including arginine, via the intermediate N-carbamoylputrescine; in this pathway, arginine is converted to agmatine, and agmatine is converted to putrescine in two single enzymatic steps." [GOC:mah, MetaCyc:PWY-43] +synonym: "putrescine anabolism from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine biosynthesis from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine formation from arginine via N-carbamoylputrescine" EXACT [] +synonym: "putrescine synthesis from arginine via N-carbamoylputrescine" EXACT [] +is_a: GO:0033388 ! putrescine biosynthetic process from arginine + +[Term] +id: GO:0033391 +name: chromatoid body +namespace: cellular_component +def: "A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182)." [PMID:17183363] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0033392 +name: obsolete actin homodimerization activity +namespace: molecular_function +def: "OBSOLETE. Binding to an identical actin monomer to form a homodimer." [GOC:mah] +comment: This term was made obsolete because it was added in error; formation of an actin dimer is simply a transient step in the polymerization of actin. Also, this term may not represent a real molecular function in GO, but rather that a gene product (actin itself) is part of an actin homodimer transient protein complex. +synonym: "actin dimerization activity" BROAD [] +synonym: "actin homodimerization activity" EXACT [] +synonym: "actin polymerizing activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0033393 +name: homogalacturonan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homogalacturonan, a pectidic polymer, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:mah] +synonym: "homogalacturonan breakdown" EXACT [] +synonym: "homogalacturonan catabolism" EXACT [] +synonym: "homogalacturonan degradation" EXACT [] +xref: MetaCyc:PWY-1081 +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0010394 ! homogalacturonan metabolic process + +[Term] +id: GO:0033394 +name: beta-alanine biosynthetic process via 1,3 diaminopropane +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 1,3 diaminopropane." [GOC:mah, MetaCyc:PWY-3981] +synonym: "beta-alanine anabolism via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine biosynthesis via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine formation via 1,3 diaminopropane" EXACT [] +synonym: "beta-alanine synthesis via 1,3 diaminopropane" EXACT [] +xref: MetaCyc:PWY-3981 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033395 +name: beta-alanine biosynthetic process via 3-hydroxypropionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-hydroxypropionate." [GOC:mah, MetaCyc:PWY-3941] +synonym: "beta-alanine anabolism via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine biosynthesis via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine formation via 3-hydroxypropionate" EXACT [] +synonym: "beta-alanine synthesis via 3-hydroxypropionate" EXACT [] +xref: MetaCyc:PWY-3941 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033396 +name: beta-alanine biosynthetic process via 3-ureidopropionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-alanine via the intermediate 3-ureidopropionate." [GOC:mah, MetaCyc:PWY-3982] +synonym: "beta-alanine anabolism via 3-ureidopropionate" EXACT [] +synonym: "beta-alanine formation via 3-ureidopropionate" EXACT [] +synonym: "beta-alanine synthesis via 3-ureidopropionate" EXACT [] +xref: MetaCyc:PWY-3982 +is_a: GO:0019483 ! beta-alanine biosynthetic process + +[Term] +id: GO:0033397 +name: zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "zeatin metabolism" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0033398 +name: zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "zeatin anabolism" EXACT [] +synonym: "zeatin biosynthesis" EXACT [] +synonym: "zeatin formation" EXACT [] +synonym: "zeatin synthesis" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0033397 ! zeatin metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0033399 +name: cis-zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "cis-zeatin metabolism" EXACT [] +is_a: GO:0033397 ! zeatin metabolic process + +[Term] +id: GO:0033400 +name: trans-zeatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "trans-zeatin metabolism" EXACT [] +is_a: GO:0033397 ! zeatin metabolic process + +[Term] +id: GO:0033401 +name: UUU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UUU codon." [GOC:mah] +comment: Note that in the standard genetic code, TTT codes for phenylalanine. +synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TTT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033402 +name: UUC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UUC codon." [GOC:mah] +comment: Note that in the standard genetic code, TTC codes for phenylalanine. +synonym: "phenylalanine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TTC codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033403 +name: UUA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UUA codon." [GOC:mah] +comment: Note that in the standard genetic code, TTA codes for leucine. +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TTA codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033404 +name: UUG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UUG codon." [GOC:mah] +comment: Note that in the standard genetic code, TTG codes for leucine. +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TTG codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033405 +name: UCU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UCU codon." [GOC:mah] +comment: Note that in the standard genetic code, TCT codes for serine. +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TCT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033406 +name: UCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UCC codon." [GOC:mah] +comment: Note that in the standard genetic code, TCC codes for serine. +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TCC codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033407 +name: UCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UCA codon." [GOC:mah] +comment: Note that in the standard genetic code, TCA codes for serine. +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TCA codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033408 +name: UCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UCG codon." [GOC:mah] +comment: Note that in the standard genetic code, TCG codes for serine. +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TCG codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033409 +name: UAU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UAU codon." [GOC:mah] +comment: Note that in the standard genetic code, TAT codes for tyrosine. +synonym: "TAT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033410 +name: UAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UAC codon." [GOC:mah] +comment: Note that in the standard genetic code, TAC codes for tyrosine. +synonym: "TAC codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "tyrosine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033411 +name: UAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UAA codon." [GOC:mah] +comment: Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. +synonym: "TAA codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033412 +name: UAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UAG codon." [GOC:mah] +comment: Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. +synonym: "TAG codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033413 +name: UGU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UGU codon." [GOC:mah] +comment: Note that in the standard genetic code, TGT codes for cysteine. +synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TGT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033414 +name: UGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UGC codon." [GOC:mah] +comment: Note that in the standard genetic code, TGC codes for cysteine. +synonym: "cysteine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "TGC codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033415 +name: UGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UGA codon." [GOC:mah] +comment: Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. +synonym: "TGA codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033416 +name: UGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a UGG codon." [GOC:mah] +comment: Note that in the standard genetic code, TGG codes for tryptophan. +synonym: "TGG codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "tryptophan tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033417 +name: CUU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CUU codon." [GOC:mah] +comment: Note that in the standard genetic code, CTT codes for leucine. +synonym: "CTT codon-amino acid adaptor activity" EXACT [GOC:mah] +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033418 +name: CUC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CUC codon." [GOC:mah] +comment: Note that in the standard genetic code, CTC codes for leucine. +synonym: "CTC codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033419 +name: CUA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CUA codon." [GOC:mah] +comment: Note that in the standard genetic code, CTA codes for leucine. +synonym: "CTA codon-amino acid adaptor activity" EXACT [GOC:mah] +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033420 +name: CUG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CUG codon." [GOC:mah] +comment: Note that in the standard genetic code, CTG codes for leucine. +synonym: "CTG codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "leucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033421 +name: CCU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCU codon." [GOC:mah] +comment: Note that in the standard genetic code, CCT codes for proline. +synonym: "CCT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033422 +name: CCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCC codon." [GOC:mah] +comment: Note that in the standard genetic code, CCC codes for proline. +synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033423 +name: CCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCA codon." [GOC:mah] +comment: Note that in the standard genetic code, CCA codes for proline. +synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033424 +name: CCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CCG codon." [GOC:mah] +comment: Note that in the standard genetic code, CCG codes for proline. +synonym: "proline tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033425 +name: CAU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAU codon." [GOC:mah] +comment: Note that in the standard genetic code, CAT codes for histidine. +synonym: "CAT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033426 +name: CAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAC codon." [GOC:mah] +comment: Note that in the standard genetic code, CAC codes for histidine. +synonym: "histidine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033427 +name: CAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAA codon." [GOC:mah] +comment: Note that in the standard genetic code, CAA codes for glutamine. +synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033428 +name: CAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CAG codon." [GOC:mah] +comment: Note that in the standard genetic code, CAG codes for glutamine. +synonym: "glutamine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033429 +name: CGU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGU codon." [GOC:mah] +comment: Note that in the standard genetic code, CGT codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "CGT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033430 +name: CGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGC codon." [GOC:mah] +comment: Note that in the standard genetic code, CGC codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033431 +name: CGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGA codon." [GOC:mah] +comment: Note that in the standard genetic code, CGA codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033432 +name: CGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a CGG codon." [GOC:mah] +comment: Note that in the standard genetic code, CGG codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033433 +name: AUU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AUU codon." [GOC:mah] +comment: Note that in the standard genetic code, ATT codes for isoleucine. +synonym: "ATT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033434 +name: AUC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AUC codon." [GOC:mah] +comment: Note that in the standard genetic code, ATC codes for isoleucine. +synonym: "ATC codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033435 +name: AUA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AUA codon." [GOC:mah] +comment: Note that in the standard genetic code, ATA codes for isoleucine. +synonym: "ATA codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "isoleucine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033436 +name: AUG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AUG codon." [GOC:mah] +comment: Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. +synonym: "ATG codon-amino acid adaptor activity" EXACT [GOC:mah] +synonym: "initiator methionine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "methionine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033437 +name: ACU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACU codon." [GOC:mah] +comment: Note that in the standard genetic code, ACT codes for threonine. +synonym: "ACT codon-amino acid adaptor activity" EXACT [GOC:mah] +synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033438 +name: ACC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACC codon." [GOC:mah] +comment: Note that in the standard genetic code, ACC codes for threonine. +synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033439 +name: ACA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACA codon." [GOC:mah] +comment: Note that in the standard genetic code, ACA codes for threonine. +synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033440 +name: ACG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an ACG codon." [GOC:mah] +comment: Note that in the standard genetic code, ACG codes for threonine. +synonym: "threonine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033441 +name: AAU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAU codon." [GOC:mah] +comment: Note that in the standard genetic code, AAT codes for asparagine. +synonym: "AAT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033442 +name: AAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAC codon." [GOC:mah] +comment: Note that in the standard genetic code, AAC codes for asparagine. +synonym: "asparagine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033443 +name: AAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAA codon." [GOC:mah] +comment: Note that in the standard genetic code, AAA codes for lysine. +synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033444 +name: AAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AAG codon." [GOC:mah] +comment: Note that in the standard genetic code, AAG codes for lysine. +synonym: "lysine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033445 +name: AGU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGU codon." [GOC:mah] +comment: Note that in the standard genetic code, AGT codes for serine. +synonym: "AGT codon-amino acid adaptor activity" EXACT [GOC:mah] +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033446 +name: AGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGC codon." [GOC:mah] +comment: Note that in the standard genetic code, AGC codes for serine. +synonym: "serine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033447 +name: AGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGA codon." [GOC:mah] +comment: Note that in the standard genetic code, AGA codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033448 +name: AGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes an AGG codon." [GOC:mah] +comment: Note that in the standard genetic code, AGG codes for arginine. +synonym: "arginine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033449 +name: GUU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GUU codon." [GOC:mah] +comment: Note that in the standard genetic code, GTT codes for valine. +synonym: "GTT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033450 +name: GUC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GUC codon." [GOC:mah] +comment: Note that in the standard genetic code, GTC codes for valine. +synonym: "GTC codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033451 +name: GUA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GUA codon." [GOC:mah] +comment: Note that in the standard genetic code, GTA codes for valine. +synonym: "GTA codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033452 +name: GUG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GUG codon." [GOC:mah] +comment: Note that in the standard genetic code, GTG codes for valine. +synonym: "GTG codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "valine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033453 +name: GCU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCU codon." [GOC:mah] +comment: Note that in the standard genetic code, GCT codes for alanine. +synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "GCT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033454 +name: GCC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCC codon." [GOC:mah] +comment: Note that in the standard genetic code, GCC codes for alanine. +synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033455 +name: GCA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCA codon." [GOC:mah] +comment: Note that in the standard genetic code, GCA codes for alanine. +synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033456 +name: GCG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GCG codon." [GOC:mah] +comment: Note that in the standard genetic code, GCG codes for alanine. +synonym: "alanine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033457 +name: GAU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAU codon." [GOC:mah] +comment: Note that in the standard genetic code, GAT codes for aspartic acid. +synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] +synonym: "GAT codon-amino acid adaptor activity" EXACT [GOC:hjd] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033458 +name: GAC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAC codon." [GOC:mah] +comment: Note that in the standard genetic code, GAC codes for aspartic acid. +synonym: "aspartic acid tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033459 +name: GAA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAA codon." [GOC:mah] +comment: Note that in the standard genetic code, GAA codes for glutamic acid. +synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033460 +name: GAG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GAG codon." [GOC:mah] +comment: Note that in the standard genetic code, GAG codes for glutamic acid. +synonym: "glutamic acid tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033461 +name: GGU codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGU codon." [GOC:mah] +comment: Note that in the standard genetic code, GGT codes for glycine. +synonym: "GGT codon-amino acid adaptor activity" EXACT [GOC:hjd] +synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033462 +name: GGC codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGC codon." [GOC:mah] +comment: Note that in the standard genetic code, GGC codes for glycine. +synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033463 +name: GGA codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGA codon." [GOC:mah] +comment: Note that in the standard genetic code, GGA codes for glycine. +synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033464 +name: GGG codon-amino acid adaptor activity +namespace: molecular_function +def: "A triplet codon-amino acid adaptor activity that recognizes a GGG codon." [GOC:mah] +comment: Note that in the standard genetic code, GGG codes for glycine. +synonym: "glycine tRNA" RELATED [GOC:hjd, GOC:mah] +is_a: GO:0030533 ! triplet codon-amino acid adaptor activity + +[Term] +id: GO:0033465 +name: cis-zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cis-zeatin, (2Z)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "cis-zeatin anabolism" EXACT [] +synonym: "cis-zeatin biosynthesis" EXACT [] +synonym: "cis-zeatin formation" EXACT [] +synonym: "cis-zeatin synthesis" EXACT [] +xref: MetaCyc:PWY-2781 +is_a: GO:0033398 ! zeatin biosynthetic process +is_a: GO:0033399 ! cis-zeatin metabolic process + +[Term] +id: GO:0033466 +name: trans-zeatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trans-zeatin, (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol." [GOC:mah] +synonym: "trans-zeatin anabolism" EXACT [] +synonym: "trans-zeatin biosynthesis" EXACT [] +synonym: "trans-zeatin formation" EXACT [] +synonym: "trans-zeatin synthesis" EXACT [] +xref: MetaCyc:PWY-2681 +is_a: GO:0033398 ! zeatin biosynthetic process +is_a: GO:0033400 ! trans-zeatin metabolic process + +[Term] +id: GO:0033467 +name: CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] +synonym: "CMP-KDO metabolic process" EXACT [] +synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] +synonym: "CMP-ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033468 +name: CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CMP-keto-3-deoxy-D-manno-octulosonic acid, a substance composed of the acidic sugar 3-deoxy-D-manno-octulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:mah, MetaCyc:PWY-5111] +synonym: "CMP-KDO biosynthesis" EXACT [] +synonym: "CMP-KDO biosynthetic process" EXACT [] +synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] +synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] +synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] +synonym: "CMP-keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] +synonym: "CMP-ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] +xref: MetaCyc:KDOSYN-PWY +xref: MetaCyc:PWY-1269 +xref: MetaCyc:PWY-5111 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033467 ! CMP-keto-3-deoxy-D-manno-octulosonic acid metabolic process + +[Term] +id: GO:0033469 +name: gibberellin 12 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah] +synonym: "GA12 metabolic process" EXACT [] +synonym: "gibberellin 12 metabolism" EXACT [] +synonym: "gibberellin A12 metabolic process" EXACT [] +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0033470 +name: gibberellin 12 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gibberellin 12, (1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid 1meta,4a-dimethyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid." [GOC:mah] +synonym: "GA12 biosynthetic process" EXACT [] +synonym: "gibberellin 12 anabolism" EXACT [] +synonym: "gibberellin 12 biosynthesis" EXACT [] +synonym: "gibberellin 12 formation" EXACT [] +synonym: "gibberellin 12 synthesis" EXACT [] +synonym: "gibberellin A12 biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5034 +is_a: GO:0009686 ! gibberellin biosynthetic process +is_a: GO:0033469 ! gibberellin 12 metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0033471 +name: GDP-L-galactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] +synonym: "GDP-L-galactose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033472 +name: GDP-L-galactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-galactose, a substance composed of L-galactose in glycosidic linkage with guanosine diphosphate." [GOC:mah] +synonym: "GDP-L-galactose anabolism" EXACT [] +synonym: "GDP-L-galactose biosynthesis" EXACT [] +synonym: "GDP-L-galactose formation" EXACT [] +synonym: "GDP-L-galactose synthesis" EXACT [] +xref: MetaCyc:PWY-5115 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033471 ! GDP-L-galactose metabolic process + +[Term] +id: GO:0033473 +name: indoleacetic acid conjugate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] +synonym: "IAA conjugate metabolic process" EXACT [] +synonym: "indole acetic acid conjugate metabolic process" EXACT [] +synonym: "indole acetic acid conjugate metabolism" EXACT [] +synonym: "indoleacetic acid conjugate metabolism" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process + +[Term] +id: GO:0033474 +name: indoleacetic acid conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule." [GOC:mah] +synonym: "IAA conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid conjugate anabolism" EXACT [] +synonym: "indoleacetic acid conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid conjugate formation" EXACT [] +synonym: "indoleacetic acid conjugate synthesis" EXACT [] +is_a: GO:0009851 ! auxin biosynthetic process +is_a: GO:0033473 ! indoleacetic acid conjugate metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process + +[Term] +id: GO:0033475 +name: indoleacetic acid amide conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond." [GOC:mah, MetaCyc:PWY-1782] +synonym: "IAA amide conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid amide conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid amide conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid amide conjugate anabolism" EXACT [] +synonym: "indoleacetic acid amide conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid amide conjugate formation" EXACT [] +synonym: "indoleacetic acid amide conjugate synthesis" EXACT [] +xref: MetaCyc:PWY-1782 +is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0033476 +name: indoleacetic acid ester conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond." [GOC:mah, MetaCyc:PWY-1741] +synonym: "IAA ester conjugate biosynthetic process" EXACT [] +synonym: "indole acetic acid ester conjugate biosynthesis" EXACT [] +synonym: "indole acetic acid ester conjugate biosynthetic process" EXACT [] +synonym: "indoleacetic acid ester conjugate anabolism" EXACT [] +synonym: "indoleacetic acid ester conjugate biosynthesis" EXACT [] +synonym: "indoleacetic acid ester conjugate formation" EXACT [] +synonym: "indoleacetic acid ester conjugate synthesis" EXACT [] +xref: MetaCyc:PWY-1741 +is_a: GO:0033474 ! indoleacetic acid conjugate biosynthetic process + +[Term] +id: GO:0033477 +name: S-methylmethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [GOC:mah, PMID:12692340] +synonym: "S-methylmethionine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0033478 +name: UDP-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [GOC:mah, PMID:15134748] +synonym: "UDP-rhamnose metabolism" EXACT [] +xref: MetaCyc:PWY-3261 +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033479 +name: UDP-D-galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-galacturonate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0033480 +name: UDP-D-galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-galacturonate, a substance composed of galacturonic acid in glycosidic linkage with uridine diphosphate." [GOC:mah] +synonym: "UDP-D-galacturonate anabolism" EXACT [] +synonym: "UDP-D-galacturonate biosynthesis" EXACT [] +synonym: "UDP-D-galacturonate formation" EXACT [] +synonym: "UDP-D-galacturonate synthesis" EXACT [] +xref: MetaCyc:PWY-4 +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0033479 ! UDP-D-galacturonate metabolic process + +[Term] +id: GO:0033481 +name: galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galacturonate, the anion of galacturonic acid." [GOC:mah] +synonym: "galacturonate anabolism" EXACT [] +synonym: "galacturonate biosynthesis" EXACT [] +synonym: "galacturonate formation" EXACT [] +synonym: "galacturonate synthesis" EXACT [] +is_a: GO:0019586 ! galacturonate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0033482 +name: D-galacturonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:jsg, GOC:mah] +synonym: "D-galacturonate anabolism" EXACT [] +synonym: "D-galacturonate biosynthesis" EXACT [] +synonym: "D-galacturonate formation" EXACT [] +synonym: "D-galacturonate synthesis" EXACT [] +is_a: GO:0033481 ! galacturonate biosynthetic process +is_a: GO:0046364 ! monosaccharide biosynthetic process +is_a: GO:0046396 ! D-galacturonate metabolic process + +[Term] +id: GO:0033483 +name: gas homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell." [GOC:mah] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0033484 +name: nitric oxide homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell." [GOC:mah] +synonym: "NO homeostasis" EXACT [] +is_a: GO:0033483 ! gas homeostasis + +[Term] +id: GO:0033485 +name: cyanidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] +synonym: "cyanidin 3-O-glucoside anabolism" EXACT [] +synonym: "cyanidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "cyanidin 3-O-glucoside formation" EXACT [] +synonym: "cyanidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5125 +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:1901038 ! cyanidin 3-O-glucoside metabolic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:0033486 +name: delphinidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5153] +synonym: "delphinidin 3-O-glucoside anabolism" EXACT [] +synonym: "delphinidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "delphinidin 3-O-glucoside formation" EXACT [] +synonym: "delphinidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5153 +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:0033487 +name: pelargonidin 3-O-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pelargonidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits." [GOC:mah, MetaCyc:PWY-5125] +synonym: "pelargonidin 3-O-glucoside anabolism" EXACT [] +synonym: "pelargonidin 3-O-glucoside biosynthesis" EXACT [] +synonym: "pelargonidin 3-O-glucoside formation" EXACT [] +synonym: "pelargonidin 3-O-glucoside synthesis" EXACT [] +xref: MetaCyc:PWY-5125 +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:0033488 +name: cholesterol biosynthetic process via 24,25-dihydrolanosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate 24,25-dihydrolanosterol." [GOC:mah, MetaCyc:PWY66-3] +synonym: "cholesterol anabolism via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol biosynthesis via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol formation via 24,25-dihydrolanosterol" EXACT [] +synonym: "cholesterol synthesis via 24,25-dihydrolanosterol" EXACT [] +xref: MetaCyc:PWY66-3 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033489 +name: cholesterol biosynthetic process via desmosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate desmosterol." [GOC:mah, MetaCyc:PWY66-4] +synonym: "cholesterol anabolism via desmosterol" EXACT [] +synonym: "cholesterol biosynthesis via desmosterol" EXACT [] +synonym: "cholesterol formation via desmosterol" EXACT [] +synonym: "cholesterol synthesis via desmosterol" EXACT [] +xref: MetaCyc:PWY66-4 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033490 +name: cholesterol biosynthetic process via lathosterol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, via the intermediate lathosterol." [GOC:mah, MetaCyc:PWY66-341] +synonym: "cholesterol anabolism via lathosterol" EXACT [] +synonym: "cholesterol biosynthesis via lathosterol" EXACT [] +synonym: "cholesterol formation via lathosterol" EXACT [] +synonym: "cholesterol synthesis via lathosterol" EXACT [] +xref: MetaCyc:PWY66-341 +is_a: GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0033491 +name: coniferin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coniferin, 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside." [GOC:mah, MetaCyc:PWY-116] +synonym: "coniferin metabolism" EXACT [] +xref: MetaCyc:PWY-116 +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:0033492 +name: esculetin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving esculetin, 6,7-dihydroxycoumarin." [GOC:mah] +synonym: "esculetin metabolism" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process + +[Term] +id: GO:0033493 +name: esculetin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of esculetin, 6,7-dihydroxycoumarin." [GOC:mah] +synonym: "esculetin anabolism" EXACT [] +synonym: "esculetin biosynthesis" EXACT [] +synonym: "esculetin formation" EXACT [] +synonym: "esculetin synthesis" EXACT [] +xref: MetaCyc:PWY-5349 +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:0033492 ! esculetin metabolic process + +[Term] +id: GO:0033494 +name: ferulate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "ferulate metabolism" EXACT [] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0033495 +name: ferulate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ferulate, (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "ferulate anabolism" EXACT [] +synonym: "ferulate biosynthesis" EXACT [] +synonym: "ferulate formation" EXACT [] +synonym: "ferulate synthesis" EXACT [] +xref: MetaCyc:PWY-5168 +is_a: GO:0033494 ! ferulate metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0033496 +name: sinapate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "sinapate metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0033497 +name: sinapate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "sinapate anabolism" EXACT [] +synonym: "sinapate biosynthesis" EXACT [] +synonym: "sinapate formation" EXACT [] +synonym: "sinapate synthesis" EXACT [] +xref: MetaCyc:PWY-5168 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0033496 ! sinapate metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0033498 +name: galactose catabolic process via D-galactonate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate D-galactonate." [GOC:mah, MetaCyc:GALDEG-PWY] +synonym: "galactose breakdown via D-galactonate" EXACT [] +synonym: "galactose catabolism via D-galactonate" EXACT [] +synonym: "galactose degradation via D-galactonate" EXACT [] +xref: MetaCyc:GALDEG-PWY +is_a: GO:0019388 ! galactose catabolic process + +[Term] +id: GO:0033499 +name: galactose catabolic process via UDP-galactose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose." [GOC:mah, MetaCyc:PWY-3821] +synonym: "galactose breakdown via UDP-galactose" EXACT [] +synonym: "galactose catabolism via UDP-galactose" EXACT [] +synonym: "galactose degradation via UDP-galactose" EXACT [] +synonym: "Leloir Pathway" RELATED [PMID:14741191] +xref: MetaCyc:PWY-3821 +is_a: GO:0019388 ! galactose catabolic process + +[Term] +id: GO:0033500 +name: carbohydrate homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0033501 +name: galactose homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state of galactose within an organism or cell." [GOC:mah] +is_a: GO:0033500 ! carbohydrate homeostasis + +[Term] +id: GO:0033502 +name: cellular galactose homeostasis +namespace: biological_process +def: "A cellular homeostatic process involved in the maintenance of an internal steady state of galactose within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] +synonym: "cell galactose homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0033501 ! galactose homeostasis +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0033503 +name: HULC complex +namespace: cellular_component +def: "A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2." [GOC:mah, PMID:17363370, PMID:17374714] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0033504 +name: floor plate development +namespace: biological_process +def: "The progression of the floor plate over time from its initial formation until its mature state." [GOC:dh] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021915 ! neural tube development + +[Term] +id: GO:0033505 +name: floor plate morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the floor plate is generated and organized." [GOC:dh] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0033504 ! floor plate development + +[Term] +id: GO:0033506 +name: glucosinolate biosynthetic process from homomethionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including homomethionine." [GOC:mah, MetaCyc:PWY-1187] +synonym: "glucosinolate anabolism from homomethionine" EXACT [] +synonym: "glucosinolate biosynthesis from homomethionine" EXACT [] +synonym: "glucosinolate formation from homomethionine" EXACT [] +synonym: "glucosinolate synthesis from homomethionine" EXACT [] +xref: MetaCyc:PWY-1187 +is_a: GO:0019761 ! glucosinolate biosynthetic process +is_a: GO:0033321 ! homomethionine metabolic process + +[Term] +id: GO:0033507 +name: glucosinolate biosynthetic process from phenylalanine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosinolates from other compounds including phenylalanine." [GOC:mah, MetaCyc:PWY-2821] +synonym: "glucosinolate anabolism from phenylalanine" EXACT [] +synonym: "glucosinolate biosynthesis from phenylalanine" EXACT [] +synonym: "glucosinolate formation from phenylalanine" EXACT [] +synonym: "glucosinolate synthesis from phenylalanine" EXACT [] +xref: MetaCyc:PWY-2821 +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0019761 ! glucosinolate biosynthetic process + +[Term] +id: GO:0033508 +name: glutamate catabolic process to butyrate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including butyrate." [GOC:mah, MetaCyc:PWY-5087] +synonym: "glutamate breakdown to butyrate" EXACT [] +synonym: "glutamate degradation to butyrate" EXACT [] +xref: MetaCyc:PWY-5087 +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:0033509 +name: glutamate catabolic process to propionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including propionate." [GOC:mah, MetaCyc:PWY-5088] +synonym: "glutamate breakdown to propionate" EXACT [] +synonym: "glutamate degradation to propionate" EXACT [] +xref: MetaCyc:PWY-5088 +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0033510 +name: luteolin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah] +synonym: "luteolin metabolism" EXACT [] +is_a: GO:0051552 ! flavone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0033511 +name: luteolin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." [GOC:mah] +synonym: "luteolin anabolism" EXACT [] +synonym: "luteolin biosynthesis" EXACT [] +synonym: "luteolin formation" EXACT [] +synonym: "luteolin synthesis" EXACT [] +xref: MetaCyc:PWY-5060 +is_a: GO:0033510 ! luteolin metabolic process +is_a: GO:0051553 ! flavone biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0033512 +name: L-lysine catabolic process to acetyl-CoA via saccharopine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine." [GOC:mah, MetaCyc:LYSINE-DEG1-PWY] +synonym: "L-lysine breakdown to acetyl-CoA via saccharopine" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via saccharopine" EXACT [] +xref: MetaCyc:LYSINE-DEG1-PWY +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033513 +name: L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide." [GOC:mah, MetaCyc:PWY-5280] +synonym: "L-lysine breakdown to acetyl-CoA via 5-aminopentanamide" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via 5-aminopentanamide" EXACT [] +xref: MetaCyc:PWY-5280 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033514 +name: L-lysine catabolic process to acetyl-CoA via L-pipecolate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate." [GOC:mah, MetaCyc:PWY-5283] +synonym: "L-lysine breakdown to acetyl-CoA via L-pipecolate" EXACT [] +synonym: "L-lysine degradation to acetyl-CoA via L-pipecolate" EXACT [] +xref: MetaCyc:PWY-5283 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033515 +name: L-lysine catabolic process using lysine 6-aminotransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase." [GOC:mah, MetaCyc:PWY-5298] +synonym: "L-lysine breakdown using lysine 6-aminotransferase" EXACT [GOC:mah] +synonym: "L-lysine degradation using lysine 6-aminotransferase" EXACT [GOC:mah] +xref: MetaCyc:PWY-5298 +is_a: GO:0019474 ! L-lysine catabolic process to acetyl-CoA + +[Term] +id: GO:0033516 +name: L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine." [GOC:mah, MetaCyc:PWY-702] +synonym: "L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +synonym: "methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] +xref: MetaCyc:PWY-702 +is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine + +[Term] +id: GO:0033517 +name: myo-inositol hexakisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [PMID:16107538] +synonym: "myo-inositol hexakisphosphate metabolism" EXACT [] +synonym: "phytate metabolic process" EXACT [] +synonym: "phytate metabolism" EXACT [] +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0033518 +name: myo-inositol hexakisphosphate dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate group from myo-inositol hexakisphosphate." [GOC:mah] +synonym: "phytate dephosphorylation" EXACT [] +xref: MetaCyc:PWY-4702 +xref: MetaCyc:PWY-4781 +is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process +is_a: GO:0046855 ! inositol phosphate dephosphorylation + +[Term] +id: GO:0033519 +name: phytyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah] +synonym: "phytyl diphosphate metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0033520 +name: phytol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." [GOC:mah] +synonym: "phytol anabolism" EXACT [] +synonym: "phytol biosynthesis" EXACT [] +synonym: "phytol formation" EXACT [] +synonym: "phytol synthesis" EXACT [] +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0033306 ! phytol metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:1903175 ! fatty alcohol biosynthetic process + +[Term] +id: GO:0033521 +name: phytyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytyl diphosphate, (2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl trihydrogen diphosphate." [GOC:mah] +synonym: "phytyl diphosphate anabolism" EXACT [] +synonym: "phytyl diphosphate biosynthesis" EXACT [] +synonym: "phytyl diphosphate formation" EXACT [] +synonym: "phytyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5063 +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0033519 ! phytyl diphosphate metabolic process + +[Term] +id: GO:0033522 +name: histone H2A ubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of one or more ubiquitin groups." [GOC:bf, GOC:mah, PMID:15509584, PMID:16473935, PMID:18430235] +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033523 +name: histone H2B ubiquitination +namespace: biological_process +def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah] +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0033524 +name: sinapate ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ester derivatives of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "sinapate ester metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0033525 +name: sinapate ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ester derivates of sinapate, (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-enoate." [GOC:mah] +synonym: "sinapate ester anabolism" EXACT [] +synonym: "sinapate ester biosynthesis" EXACT [] +synonym: "sinapate ester formation" EXACT [] +synonym: "sinapate ester synthesis" EXACT [] +xref: MetaCyc:PWY-3301 +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0033524 ! sinapate ester metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0033526 +name: tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including L-glutamate." [GOC:mah, MetaCyc:PWY-5188] +synonym: "tetrapyrrole anabolism from glutamate" EXACT [] +synonym: "tetrapyrrole biosynthesis from glutamate" EXACT [] +synonym: "tetrapyrrole formation from glutamate" EXACT [] +synonym: "tetrapyrrole synthesis from glutamate" EXACT [] +xref: MetaCyc:PWY-5188 +is_a: GO:0006536 ! glutamate metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0033527 +name: tetrapyrrole biosynthetic process from glycine and succinyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA." [GOC:mah, MetaCyc:PWY-5189] +synonym: "tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole formation from glycine and succinyl-CoA" EXACT [] +synonym: "tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [] +xref: MetaCyc:PWY-5189 +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0006544 ! glycine metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0033528 +name: S-methylmethionine cycle +namespace: biological_process +def: "A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." [GOC:mah, MetaCyc:PWY-5441] +xref: MetaCyc:PWY-5441 +is_a: GO:0033477 ! S-methylmethionine metabolic process + +[Term] +id: GO:0033529 +name: raffinose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] +synonym: "raffinose anabolism" EXACT [] +synonym: "raffinose biosynthesis" EXACT [] +synonym: "raffinose formation" EXACT [] +synonym: "raffinose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033530 ! raffinose metabolic process + +[Term] +id: GO:0033530 +name: raffinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] +synonym: "raffinose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033531 +name: stachyose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] +synonym: "stachyose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033532 +name: stachyose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] +synonym: "stachyose anabolism" EXACT [] +synonym: "stachyose biosynthesis" EXACT [] +synonym: "stachyose formation" EXACT [] +synonym: "stachyose synthesis" EXACT [] +xref: MetaCyc:PWY-5337 +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033531 ! stachyose metabolic process + +[Term] +id: GO:0033533 +name: verbascose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] +synonym: "verbascose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033534 +name: verbascose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8065] +synonym: "verbascose anabolism" EXACT [] +synonym: "verbascose biosynthesis" EXACT [] +synonym: "verbascose formation" EXACT [] +synonym: "verbascose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033533 ! verbascose metabolic process + +[Term] +id: GO:0033535 +name: ajugose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] +synonym: "ajugose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:0033536 +name: ajugose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah, MetaCyc:CPD-8066] +synonym: "ajugose anabolism" EXACT [] +synonym: "ajugose biosynthesis" EXACT [] +synonym: "ajugose formation" EXACT [] +synonym: "ajugose synthesis" EXACT [] +is_a: GO:0010325 ! raffinose family oligosaccharide biosynthetic process +is_a: GO:0033535 ! ajugose metabolic process + +[Term] +id: GO:0033537 +name: ajugose biosynthetic process using galactinol:raffinose galactosyltransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide." [GOC:mah, MetaCyc:PWY-5342] +synonym: "ajugose anabolism using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose biosynthesis using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose formation using galactinol:raffinose galactosyltransferase" EXACT [] +synonym: "ajugose synthesis using galactinol:raffinose galactosyltransferase" EXACT [] +xref: MetaCyc:PWY-5342 +is_a: GO:0033536 ! ajugose biosynthetic process + +[Term] +id: GO:0033538 +name: ajugose biosynthetic process using galactan:galactan galactosyltransferase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another." [GOC:mah, MetaCyc:PWY-5343] +synonym: "ajugose anabolism using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose biosynthesis using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose formation using galactan:galactan galactosyltransferase" EXACT [] +synonym: "ajugose synthesis using galactan:galactan galactosyltransferase" EXACT [] +xref: MetaCyc:PWY-5343 +is_a: GO:0033536 ! ajugose biosynthetic process + +[Term] +id: GO:0033539 +name: fatty acid beta-oxidation using acyl-CoA dehydrogenase +namespace: biological_process +def: "A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:FAO-PWY, MetaCyc:PWY-5136] +xref: MetaCyc:FAO-PWY +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033540 +name: fatty acid beta-oxidation using acyl-CoA oxidase +namespace: biological_process +def: "A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5136] +xref: MetaCyc:PWY-5136 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033541 +name: fatty acid beta-oxidation, unsaturated, odd number +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5137] +xref: MetaCyc:PWY-5137 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033542 +name: fatty acid beta-oxidation, unsaturated, even number +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] +xref: MetaCyc:PWY-5138 +is_a: GO:0006635 ! fatty acid beta-oxidation + +[Term] +id: GO:0033543 +name: fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] +is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number + +[Term] +id: GO:0033544 +name: fatty acid beta-oxidation, unsaturated, even number, epimerase pathway +namespace: biological_process +def: "A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, MetaCyc:PWY-5138] +is_a: GO:0033542 ! fatty acid beta-oxidation, unsaturated, even number + +[Term] +id: GO:0033545 +name: myo-inositol hexakisphosphate biosynthetic process, lipid-dependent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C." [GOC:mah, MetaCyc:PWY-6555] +synonym: "myo-inositol hexakisphosphate anabolism, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, lipid-dependent" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, lipid-dependent" EXACT [] +synonym: "phytate biosynthesis, lipid-dependent" EXACT [] +synonym: "phytate biosynthetic process, lipid-dependent" EXACT [] +xref: MetaCyc:PWY-6555 +is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process + +[Term] +id: GO:0033546 +name: myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further." [GOC:mah, MetaCyc:PWY-6554] +synonym: "myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "phytate biosynthesis, via inositol 1,3,4-trisphosphate" EXACT [] +synonym: "phytate biosynthetic process, via inositol 1,3,4-trisphosphate" EXACT [] +xref: MetaCyc:PWY-6554 +is_a: GO:0033545 ! myo-inositol hexakisphosphate biosynthetic process, lipid-dependent + +[Term] +id: GO:0033547 +name: obsolete myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 1D myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is successively phosphorylated to yield inositol hexakisphosphate." [GOC:mah, MetaCyc:PWY-4541] +comment: This term was made obsolete because its only cross-reference points to a MetaCyc entry (PWY-4541) that was deleted from the MetaCyc database. +synonym: "myo-inositol hexakisphosphate anabolism, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "phytate biosynthesis, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +synonym: "phytate biosynthetic process, via direct phosphorylation of inositol 1,4,5-trisphosphate" EXACT [] +xref: MetaCyc:PWY-4541 +is_obsolete: true + +[Term] +id: GO:0033548 +name: myo-inositol hexakisphosphate biosynthetic process, lipid-independent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate." [GOC:mah, MetaCyc:PWY-4661] +synonym: "myo-inositol hexakisphosphate anabolism, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate biosynthesis, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate formation, lipid-independent" EXACT [] +synonym: "myo-inositol hexakisphosphate synthesis, lipid-independent" EXACT [] +synonym: "phytate biosynthesis, lipid-independent" EXACT [] +synonym: "phytate biosynthetic process, lipid-independent" EXACT [] +xref: MetaCyc:PWY-4661 +is_a: GO:0010264 ! myo-inositol hexakisphosphate biosynthetic process + +[Term] +id: GO:0033549 +name: MAP kinase phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate." [GOC:mah, PMID:12184814, PMID:17208316] +synonym: "MAPK phosphatase activity" EXACT [PMID:12184814] +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0033550 +name: MAP kinase tyrosine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate." [GOC:mah] +synonym: "tyrosine-specific MAP kinase phosphatase activity" EXACT [] +is_a: GO:0004725 ! protein tyrosine phosphatase activity +is_a: GO:0033549 ! MAP kinase phosphatase activity + +[Term] +id: GO:0033551 +name: monopolin complex +namespace: cellular_component +def: "A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits." [GOC:mah, GOC:rb, PMID:17627824] +synonym: "monopolin subcomplex Csm1/Lrs4" NARROW [] +synonym: "Pcs1/Mde4 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:0033552 +name: response to vitamin B3 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:sl] +synonym: "response to niacin" NARROW [] +synonym: "response to nicotinamide" NARROW [] +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0033553 +name: rDNA heterochromatin +namespace: cellular_component +alt_id: GO:1902377 +def: "A region of heterochromatin located at the rDNA repeats in a chromosome." [GOC:mah, PMID:20661445] +synonym: "nuclear rDNA heterochromatin" NARROW [] +synonym: "ribosomal DNA heterochromatin" EXACT [] +synonym: "ribosomal DNA heterochromatin of cell nucleus" NARROW [GOC:TermGenie] +synonym: "ribosomal DNA heterochromatin of nucleus" NARROW [GOC:TermGenie] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0033554 +name: cellular response to stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0006950 ! response to stress +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0033555 +name: multicellular organismal response to stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] +is_a: GO:0006950 ! response to stress +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0033556 +name: dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol." [GOC:mah, PMID:10336995] +synonym: "dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033557 +name: Slx1-Slx4 complex +namespace: cellular_component +def: "A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes." [PMID:14528010, PMID:16467377] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0033558 +name: protein deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] +xref: Reactome:R-HSA-5693092 "Unknown deacetylase deacetylates 7K-BACE1(46-501)" +xref: Reactome:R-HSA-8952069 "HDAC4 deacetylates RUNX3" +xref: Reactome:R-HSA-9626962 "SIRT1 deacetylates FOXO1" +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0033559 +name: unsaturated fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah] +synonym: "unsaturated fatty acid metabolism" EXACT [] +xref: MetaCyc:PWY-762 +xref: MetaCyc:PWY-782 +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0033560 +name: folate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+." [GOC:pde] +xref: Reactome:R-HSA-197963 "Folate is reduced to dihydrofolate (DHF)" +xref: Reactome:R-HSA-197972 "DHF is reduced to tetrahydrofolate (THF)" +xref: RHEA:31103 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033561 +name: regulation of water loss via skin +namespace: biological_process +def: "A process that modulates the rate or extent of water loss from an organism via the skin." [GOC:mah] +synonym: "skin barrier function" RELATED [] +is_a: GO:0050891 ! multicellular organismal water homeostasis + +[Term] +id: GO:0033562 +name: co-transcriptional gene silencing by RNA interference machinery +namespace: biological_process +def: "A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin." [GOC:mah, GOC:vw, PMID:17512405, PMID:21151114, PMID:22431512] +synonym: "co-transcriptional gene silencing by small RNA" EXACT [GOC:vw] +synonym: "cotranscriptional gene silencing by RNA interference machinery" RELATED [] +synonym: "cotranscriptional gene silencing by small RNA" RELATED [] +synonym: "RNAi-mediated CTGS" EXACT [GOC:vw] +synonym: "small RNA-mediated cotranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0033563 +name: dorsal/ventral axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:kmv, GOC:tb] +synonym: "dorsal-ventral axon guidance" EXACT [GOC:mah] +synonym: "dorsal/ventral axon pathfinding" EXACT [GOC:mah] +synonym: "dorsoventral axon guidance" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0033564 +name: anterior/posterior axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:kmv, GOC:tb] +synonym: "anterior-posterior axon guidance" EXACT [] +synonym: "anterior/posterior axon pathfinding" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0033565 +name: ESCRT-0 complex +namespace: cellular_component +def: "A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals." [GOC:rb, PMID:12055639, PMID:17543868] +synonym: "Hrs/STAM complex" EXACT [] +synonym: "Vps27p-Hse1p complex" EXACT [] +is_a: GO:0036452 ! ESCRT complex + +[Term] +id: GO:0033566 +name: gamma-tubulin complex localization +namespace: biological_process +def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT [] +synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0033567 +name: DNA replication, Okazaki fragment processing +namespace: biological_process +def: "The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand." [GOC:mah, ISBN:0716720094] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006273 ! lagging strand elongation + +[Term] +id: GO:0033568 +name: lactoferrin receptor activity +namespace: molecular_function +def: "Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH." [GOC:bf, GOC:mlg, PMID:16261254] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0033569 +name: lactoferrin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lactoferrin from one side of a membrane to the other." [GOC:mlg] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0033570 +name: obsolete transferrin transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of transferrin from one side of a membrane to the other." [GOC:mlg] +comment: This term was obsoleted because there is no evidence that this function exists. +is_obsolete: true + +[Term] +id: GO:0033571 +name: lactoferrin transport +namespace: biological_process +def: "The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0033572 +name: transferrin transport +namespace: biological_process +def: "The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg] +synonym: "melanotransferrin transport" EXACT [PR:000001887] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0033573 +name: high-affinity iron permease complex +namespace: cellular_component +def: "A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jp, PMID:16522632, PMID:8599111] +synonym: "high affinity iron permease complex" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1902495 ! transmembrane transporter complex +is_a: GO:1905862 ! ferroxidase complex + +[Term] +id: GO:0033574 +name: response to testosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:sl] +synonym: "response to testosterone stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0033575 +name: protein glycosylation at cell surface +namespace: biological_process +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell." [GOC:mah, GOC:pr, PMID:12042244] +synonym: "protein amino acid glycosylation at cell surface" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0033576 +name: protein glycosylation in cytosol +namespace: biological_process +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the cytosol." [GOC:mah, GOC:pr, PMID:12042244] +synonym: "protein amino acid glycosylation in cytosol" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0033577 +name: protein glycosylation in endoplasmic reticulum +namespace: biological_process +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah, GOC:pr, PMID:12042244] +synonym: "core glycosylation" RELATED [PMID:6345657] +synonym: "protein amino acid glycosylation in endoplasmic reticulum" EXACT [GOC:bf] +synonym: "protein amino acid glycosylation in ER" EXACT [] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0033578 +name: protein glycosylation in Golgi +namespace: biological_process +def: "The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah, GOC:pr, PMID:12042244] +synonym: "protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +synonym: "terminal glycosylation" NARROW [PMID:6345657] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0033579 +name: protein galactosylation in endoplasmic reticulum +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum." [GOC:mah] +synonym: "protein amino acid galactosylation in endoplasmic reticulum" EXACT [GOC:bf] +synonym: "protein amino acid galactosylation in ER" EXACT [] +is_a: GO:0033577 ! protein glycosylation in endoplasmic reticulum +is_a: GO:0042125 ! protein galactosylation + +[Term] +id: GO:0033580 +name: protein galactosylation at cell surface +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid at the surface of a cell." [GOC:mah] +synonym: "protein amino acid galactosylation at cell surface" EXACT [GOC:bf] +is_a: GO:0033575 ! protein glycosylation at cell surface +is_a: GO:0042125 ! protein galactosylation + +[Term] +id: GO:0033581 +name: protein galactosylation in Golgi +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:mah] +synonym: "protein amino acid galactosylation in Golgi" EXACT [GOC:bf] +is_a: GO:0033578 ! protein glycosylation in Golgi +is_a: GO:0042125 ! protein galactosylation + +[Term] +id: GO:0033582 +name: protein galactosylation in cytosol +namespace: biological_process +def: "The addition of a galactose unit to a protein amino acid in the cytosol." [GOC:mah] +synonym: "protein amino acid galactosylation in cytosol" EXACT [GOC:bf] +is_a: GO:0033576 ! protein glycosylation in cytosol +is_a: GO:0042125 ! protein galactosylation + +[Term] +id: GO:0033583 +name: rhabdomere membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the rhabdomere." [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0033584 +name: tyrosine biosynthetic process from chorismate via L-arogenate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:mah] +synonym: "tyrosine anabolism from chorismate via L-arogenate" EXACT [] +synonym: "tyrosine formation from chorismate via L-arogenate" EXACT [] +synonym: "tyrosine synthesis from chorismate via L-arogenate" EXACT [] +xref: MetaCyc:PWY-3461 +is_a: GO:0006571 ! tyrosine biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0033585 +name: L-phenylalanine biosynthetic process from chorismate via phenylpyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate phenylpyruvate." [GOC:go_curators] +synonym: "L-phenylalanine anabolism from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine biosynthesis from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine formation from chorismate via phenylpyruvate" EXACT [] +synonym: "L-phenylalanine synthesis from chorismate via phenylpyruvate" EXACT [] +xref: MetaCyc:PHESYN +is_a: GO:0009094 ! L-phenylalanine biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0033586 +name: L-phenylalanine biosynthetic process from chorismate via L-arogenate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine from other compounds, including chorismate, via the intermediate L-arogenate." [GOC:go_curators] +synonym: "L-phenylalanine anabolism from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine biosynthesis from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine formation from chorismate via L-arogenate" EXACT [] +synonym: "L-phenylalanine synthesis from chorismate via L-arogenate" EXACT [] +xref: MetaCyc:PWY-3462 +is_a: GO:0009094 ! L-phenylalanine biosynthetic process +is_a: GO:0046417 ! chorismate metabolic process + +[Term] +id: GO:0033588 +name: elongator holoenzyme complex +namespace: cellular_component +alt_id: GO:0033589 +def: "A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA." [GOC:bhm, GOC:jh, GOC:mah, GOC:vw, PMID:11435442, PMID:11689709, PMID:15769872, PMID:17018299, PMID:18755837, PMID:23165209] +comment: Despite its name, this complex is not directly involved in transcriptional elongation (PMID:23165209). +synonym: "Elongator core complex" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0033590 +name: response to cobalamin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:sl] +synonym: "response to vitamin B12" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0033591 +name: response to L-ascorbic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:sl] +synonym: "response to ascorbic acid" BROAD [] +synonym: "response to L-ascorbate" EXACT [] +synonym: "response to vitamin C" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:0034284 ! response to monosaccharide + +[Term] +id: GO:0033592 +name: RNA strand annealing activity +namespace: molecular_function +def: "An activity that facilitates the formation of a complementary double-stranded RNA molecule." [GOC:mah, PMID:7543843] +is_a: GO:0003727 ! single-stranded RNA binding +is_a: GO:0140666 ! annealing activity + +[Term] +id: GO:0033593 +name: BRCA2-MAGE-D1 complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth." [PMID:15930293] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0033594 +name: response to hydroxyisoflavone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah] +is_a: GO:0080184 ! response to phenylpropanoid +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0033595 +name: response to genistein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] +is_a: GO:0033594 ! response to hydroxyisoflavone + +[Term] +id: GO:0033596 +name: TSC1-TSC2 complex +namespace: cellular_component +def: "A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway." [PMID:10585443, PMID:17121544, PMID:9580671] +synonym: "tuberin-hamartin complex" EXACT [] +synonym: "tuberous sclerosis complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0033597 +name: mitotic checkpoint complex +namespace: cellular_component +def: "A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20." [PMID:10704439, PMID:11535616, PMID:11726501, PMID:17650307] +synonym: "MCC" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0033598 +name: mammary gland epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:mah] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0061180 ! mammary gland epithelium development + +[Term] +id: GO:0033599 +name: regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033600 +name: negative regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +synonym: "down regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "down-regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "downregulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "inhibition of mammary gland epithelial cell proliferation" NARROW [] +is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033601 +name: positive regulation of mammary gland epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation." [GOC:mah] +synonym: "activation of mammary gland epithelial cell proliferation" NARROW [] +synonym: "stimulation of mammary gland epithelial cell proliferation" NARROW [] +synonym: "up regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "up-regulation of mammary gland epithelial cell proliferation" EXACT [] +synonym: "upregulation of mammary gland epithelial cell proliferation" EXACT [] +is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0033598 ! mammary gland epithelial cell proliferation + +[Term] +id: GO:0033602 +name: negative regulation of dopamine secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] +synonym: "down regulation of dopamine secretion" EXACT [] +synonym: "down-regulation of dopamine secretion" EXACT [] +synonym: "downregulation of dopamine secretion" EXACT [] +synonym: "inhibition of dopamine secretion" NARROW [] +is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033604 ! negative regulation of catecholamine secretion +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0033603 +name: positive regulation of dopamine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine." [GOC:sl] +synonym: "activation of dopamine secretion" NARROW [] +synonym: "stimulation of dopamine secretion" NARROW [] +synonym: "up regulation of dopamine secretion" EXACT [] +synonym: "up-regulation of dopamine secretion" EXACT [] +synonym: "upregulation of dopamine secretion" EXACT [] +is_a: GO:0014059 ! regulation of dopamine secretion +is_a: GO:0033605 ! positive regulation of catecholamine secretion +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0014046 ! dopamine secretion + +[Term] +id: GO:0033604 +name: negative regulation of catecholamine secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] +synonym: "down regulation of catecholamine secretion" EXACT [] +synonym: "down-regulation of catecholamine secretion" EXACT [] +synonym: "downregulation of catecholamine secretion" EXACT [] +synonym: "inhibition of catecholamine secretion" NARROW [] +is_a: GO:0050433 ! regulation of catecholamine secretion +is_a: GO:0051953 ! negative regulation of amine transport +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0033605 +name: positive regulation of catecholamine secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine." [GOC:mah] +synonym: "activation of catecholamine secretion" NARROW [] +synonym: "stimulation of catecholamine secretion" NARROW [] +synonym: "up regulation of catecholamine secretion" EXACT [] +synonym: "up-regulation of catecholamine secretion" EXACT [] +synonym: "upregulation of catecholamine secretion" EXACT [] +is_a: GO:0050433 ! regulation of catecholamine secretion +is_a: GO:0051954 ! positive regulation of amine transport +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0033606 +name: chemokine receptor transport within lipid bilayer +namespace: biological_process +def: "The directed movement of a chemokine receptor within a lipid bilayer." [GOC:mah] +synonym: "chemokine receptor translocation within membrane" EXACT [] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0033607 +name: SOD1-Bcl-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway." [PMID:15233914, PMID:16790527] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0033608 +name: formyl-CoA transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA." [EC:2.8.3.16, RHEA:16545] +synonym: "formyl-CoA oxalate CoA-transferase activity" RELATED [EC:2.8.3.16] +synonym: "formyl-CoA:oxalate CoA-transferase activity" RELATED [EC:2.8.3.16] +synonym: "formyl-coenzyme A transferase activity" RELATED [EC:2.8.3.16] +xref: EC:2.8.3.16 +xref: KEGG_REACTION:R07290 +xref: MetaCyc:RXN0-1382 +xref: RHEA:16545 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0033609 +name: oxalate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxalate, the organic acid ethanedioate." [GOC:mlg] +synonym: "ethanedioate metabolic process" EXACT [] +synonym: "ethanedioic acid metabolic process" EXACT [] +synonym: "oxalate metabolism" EXACT [] +synonym: "oxalic acid metabolic process" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0033610 +name: oxalate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oxalate, the organic acid ethanedioate." [GOC:mlg] +synonym: "ethanedioate biosynthetic process" EXACT [] +synonym: "ethanedioic acid biosynthetic process" EXACT [] +synonym: "oxalate anabolism" EXACT [] +synonym: "oxalate biosynthesis" EXACT [] +synonym: "oxalate formation" EXACT [] +synonym: "oxalate synthesis" EXACT [] +synonym: "oxalic acid biosynthetic process" EXACT [] +is_a: GO:0033609 ! oxalate metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process + +[Term] +id: GO:0033611 +name: oxalate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oxalate, the organic acid ethanedioate." [GOC:mlg] +synonym: "ethanedioate catabolic process" EXACT [] +synonym: "ethanedioic acid catabolic process" EXACT [] +synonym: "oxalate breakdown" EXACT [] +synonym: "oxalate catabolism" EXACT [] +synonym: "oxalate degradation" EXACT [] +synonym: "oxalic acid catabolic process" EXACT [] +is_a: GO:0033609 ! oxalate metabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0033612 +name: receptor serine/threonine kinase binding +namespace: molecular_function +def: "Binding to a receptor that possesses protein serine/threonine kinase activity." [GOC:mah] +synonym: "transmembrane receptor protein serine/threonine kinase ligand binding" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0033614 +name: chloroplast proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0009658 ! chloroplast organization + +[Term] +id: GO:0033615 +name: mitochondrial proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0033616 +name: plasma membrane proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane." [GOC:mah] +is_a: GO:0043461 ! proton-transporting ATP synthase complex assembly +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0033617 +name: mitochondrial cytochrome c oxidase assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane." [GOC:mah] +synonym: "mitochondrial cytochrome c oxidase biogenesis" BROAD [] +synonym: "mitochondrial cytochrome c oxidase complex assembly" EXACT [] +synonym: "mitochondrial respiratory chain complex IV assembly" EXACT [] +is_a: GO:0008535 ! respiratory chain complex IV assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0033618 +name: plasma membrane respiratory chain complex IV assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane." [GOC:mah] +synonym: "plasma membrane cytochrome c oxidase biogenesis" BROAD [] +synonym: "plasma membrane cytochrome c oxidase complex assembly" EXACT [] +is_a: GO:0008535 ! respiratory chain complex IV assembly +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0033619 +name: membrane protein proteolysis +namespace: biological_process +def: "The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains." [GOC:pde] +is_a: GO:0006508 ! proteolysis + +[Term] +id: GO:0033620 +name: Mei2 nuclear dot complex +namespace: cellular_component +def: "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [GOC:vw, PMID:12808043] +synonym: "Mei2 dot" EXACT [] +synonym: "Mei2 nuclear dot" BROAD [] +synonym: "nuclear body" RELATED [] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0033621 +name: nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +namespace: biological_process +def: "The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [PMID:16823445] +comment: Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing. +synonym: "degradation of meiosis-specific transcripts" EXACT [] +synonym: "mRNA breakdown, meiosis-specific transcripts" EXACT [] +synonym: "mRNA catabolism, meiosis-specific transcripts" EXACT [] +synonym: "mRNA degradation, meiosis-specific transcripts" EXACT [] +synonym: "nuclear mRNA catabolic process, meiosis-specific transcripts" EXACT [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0033622 +name: integrin activation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "integrin complex activation" EXACT [] +synonym: "integrin complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0033623 +name: regulation of integrin activation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "regulation of integrin complex activation" EXACT [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033624 +name: negative regulation of integrin activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "negative regulation of integrin complex activation" EXACT [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0033623 ! regulation of integrin activation +relationship: negatively_regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033625 +name: positive regulation of integrin activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of integrin activation." [GOC:add] +synonym: "positive regulation of integrin complex activation" EXACT [] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0033623 ! regulation of integrin activation +relationship: positively_regulates GO:0033622 ! integrin activation + +[Term] +id: GO:0033626 +name: positive regulation of integrin activation by cell surface receptor linked signal transduction +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell that lead to the increased affinity of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, for its extracellular ligands." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell surface receptor linked signal transduction leading to integrin activation" EXACT [GOC:bf, GOC:signaling] +synonym: "cell surface receptor linked signal transduction leading to integrin complex activation" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway +is_a: GO:0033625 ! positive regulation of integrin activation + +[Term] +id: GO:0033627 +name: cell adhesion mediated by integrin +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0033628 +name: regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033629 +name: negative regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "negative regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +relationship: negatively_regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033630 +name: positive regulation of cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cell adhesion mediated by integrin." [GOC:add] +synonym: "positive regulation of cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +is_a: GO:0045785 ! positive regulation of cell adhesion +relationship: positively_regulates GO:0033627 ! cell adhesion mediated by integrin + +[Term] +id: GO:0033631 +name: cell-cell adhesion mediated by integrin +namespace: biological_process +def: "The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits." [GOC:add, PMID:12213832, PMID:14754902] +synonym: "cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0033627 ! cell adhesion mediated by integrin +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0033632 +name: regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0033628 ! regulation of cell adhesion mediated by integrin +relationship: regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033633 +name: negative regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "negative regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0033629 ! negative regulation of cell adhesion mediated by integrin +is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin +relationship: negatively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033634 +name: positive regulation of cell-cell adhesion mediated by integrin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of cell-cell adhesion mediated by integrin." [GOC:add] +synonym: "positive regulation of cell-cell adhesion mediated by integrin complex" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0033630 ! positive regulation of cell adhesion mediated by integrin +is_a: GO:0033632 ! regulation of cell-cell adhesion mediated by integrin +relationship: positively_regulates GO:0033631 ! cell-cell adhesion mediated by integrin + +[Term] +id: GO:0033635 +name: modulation by symbiont of host response to abiotic stimulus +namespace: biological_process +def: "Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: regulates GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0033636 +name: modulation by symbiont of host response to temperature stimulus +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "modulation by symbiont of host response to thermal stimulus" EXACT [] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus +relationship: regulates GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0033637 +name: modulation by symbiont of host response to cold +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "freezing tolerance" RELATED [] +is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus + +[Term] +id: GO:0033638 +name: modulation by symbiont of host response to heat +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response to heat shock" RELATED [] +is_a: GO:0033636 ! modulation by symbiont of host response to temperature stimulus + +[Term] +id: GO:0033639 +name: modulation by symbiont of host response to water +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus + +[Term] +id: GO:0033640 +name: modulation by symbiont of host response to osmotic stress +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus +relationship: regulates GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0033641 +name: modulation by symbiont of host response to pH +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus +relationship: regulates GO:0009268 ! response to pH + +[Term] +id: GO:0033642 +name: modulation by symbiont of host response to gravitational stimulus +namespace: biological_process +def: "Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response to gravitational stimulus" BROAD [] +is_a: GO:0033635 ! modulation by symbiont of host response to abiotic stimulus +relationship: regulates GO:0009629 ! response to gravity + +[Term] +id: GO:0033643 +name: host cell part +namespace: cellular_component +def: "Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_a: GO:0018995 ! host cellular component +relationship: part_of GO:0043657 ! host cell + +[Term] +id: GO:0033644 +name: host cell membrane +namespace: cellular_component +def: "Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0033645 +name: host cell endomembrane system +namespace: cellular_component +def: "A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0033646 +name: host intracellular part +namespace: cellular_component +def: "Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "host cell intracellular part" EXACT [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0043656 ! host intracellular region + +[Term] +id: GO:0033647 +name: host intracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033646 ! host intracellular part + +[Term] +id: GO:0033648 +name: host intracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "host intracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0033647 ! host intracellular organelle + +[Term] +id: GO:0033650 +name: host cell mitochondrion +namespace: cellular_component +def: "A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "host mitochondria" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0033651 +name: host cell plastid +namespace: cellular_component +def: "Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0033652 +name: host cell chloroplast +namespace: cellular_component +def: "A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033651 ! host cell plastid + +[Term] +id: GO:0033653 +name: host cell chloroplast part +namespace: cellular_component +def: "Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "host chloroplast component" EXACT [] +is_a: GO:0033652 ! host cell chloroplast + +[Term] +id: GO:0033654 +name: host cell chloroplast thylakoid membrane +namespace: cellular_component +def: "Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033653 ! host cell chloroplast part +is_a: GO:0044160 ! host thylakoid membrane + +[Term] +id: GO:0033655 +name: host cell cytoplasm part +namespace: cellular_component +def: "Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "cytoplasm component" BROAD [] +is_a: GO:0033646 ! host intracellular part +relationship: part_of GO:0030430 ! host cell cytoplasm + +[Term] +id: GO:0033656 +name: modification by symbiont of host chloroplast +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0033657 +name: modification by symbiont of host chloroplast part +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033656 ! modification by symbiont of host chloroplast + +[Term] +id: GO:0033658 +name: modification by symbiont of host chloroplast thylakoid +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033657 ! modification by symbiont of host chloroplast part + +[Term] +id: GO:0033659 +name: modification by symbiont of host mitochondrion +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0033660 +name: suppression by symbiont of host resistance gene-dependent defense response +namespace: biological_process +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "down regulation by symbiont of defense response in host by specific elicitors" EXACT [] +synonym: "down-regulation by symbiont of host gene-for-gene resistance" EXACT [] +synonym: "downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "inhibition by symbiont of host resistance gene-dependent defense response" NARROW [] +synonym: "negative regulation by symbiont of host resistance gene-dependent defense response" EXACT [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response + +[Term] +id: GO:0033661 +name: effector-mediated defense to host-produced reactive oxygen species +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "down regulation by organism of defense-related host metabolic burst" EXACT [] +synonym: "down-regulation by organism of defense-related host oxidative burst" EXACT [] +synonym: "downregulation by organism of defense-related host AOS production" EXACT [] +synonym: "inhibition by organism of defense-related host active oxygen species production" NARROW [] +synonym: "negative regulation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "negative regulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "negative regulation by organism of defense-related host respiratory burst" EXACT [] +synonym: "negative regulation by organism of defense-related host ROI production" EXACT [] +synonym: "negative regulation by organism of defense-related host ROS production" EXACT [] +synonym: "negative regulation by symbiont of defense-related host reactive oxygen species production" EXACT [] +synonym: "suppression by symbiont of defense-related host reactive oxygen species production" RELATED [] +is_a: GO:0052164 ! symbiont defense to host-produced reactive oxygen species + +[Term] +id: GO:0033662 +name: obsolete modulation by symbiont of host defense-related protein level +namespace: biological_process +def: "OBSOLETE. The alternation by a symbiont of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:0033663 +name: obsolete negative regulation by symbiont of host defense-related protein level +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont reduces of the levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:0033664 +name: obsolete positive regulation by symbiont of host defense-related protein level +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases levels of defense-related proteins in its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:0033665 +name: obsolete regulation of growth or development of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:dph, GOC:pamgo_curators, GOC:tb] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "modulation of growth or development of organism within host" EXACT [] +synonym: "modulation of growth or development of symbiont within host" EXACT [GOC:dph, GOC:tb] +synonym: "modulation of invasive growth" BROAD [] +synonym: "regulation of growth or development of symbiont in host" EXACT [] +synonym: "regulation of growth or development of symbiont within host" EXACT [] +is_obsolete: true +consider: GO:0044127 + +[Term] +id: GO:0033666 +name: obsolete positive regulation of growth or development of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process by which the symbiont activates, maintains or increases its size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "positive regulation of growth or development of symbiont in host" EXACT [] +synonym: "positive regulation of growth or development of symbiont within host" EXACT [] +synonym: "positive regulation of invasive growth" BROAD [] +synonym: "up regulation of growth or development of organism within host" EXACT [] +synonym: "up-regulation of growth or development of organism within host" EXACT [] +synonym: "upregulation of growth or development of organism within host" EXACT [] +is_obsolete: true +consider: GO:0044129 + +[Term] +id: GO:0033667 +name: obsolete negative regulation of growth or development of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process by which the symbiont stops, prevents or reduces its increase in size or mass or its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "down regulation of growth or development of organism within host" EXACT [] +synonym: "down-regulation of growth or development of organism within host" EXACT [] +synonym: "downregulation of growth or development of organism within host" EXACT [] +synonym: "inhibition of growth of development of organism within host" NARROW [] +synonym: "negative regulation of growth or development of symbiont in host" EXACT [] +synonym: "negative regulation of growth or development of symbiont within host" EXACT [] +synonym: "negative regulation of invasive growth" BROAD [] +is_obsolete: true +consider: GO:0044131 + +[Term] +id: GO:0033668 +name: negative regulation by symbiont of host apoptotic process +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. +synonym: "down regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "down-regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "downregulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "inhibition by organism of host apoptotic programmed cell death" NARROW [] +synonym: "negative regulation by symbiont of host apoptosis" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death +is_a: GO:0052150 ! modulation by symbiont of host apoptotic process + +[Term] +id: GO:0033670 +name: regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "NAD kinase regulator" NARROW [] +synonym: "regulation of NAD kinase activity" EXACT [] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0033671 +name: negative regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "down regulation of NAD+ kinase activity" EXACT [] +synonym: "down-regulation of NAD+ kinase activity" EXACT [] +synonym: "downregulation of NAD+ kinase activity" EXACT [] +synonym: "inhibition of NAD+ kinase activity" NARROW [] +synonym: "NAD+ kinase inhibitor" NARROW [] +is_a: GO:0033670 ! regulation of NAD+ kinase activity +is_a: GO:0033673 ! negative regulation of kinase activity + +[Term] +id: GO:0033672 +name: positive regulation of NAD+ kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NAD kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an NAD molecule." [GOC:mah] +synonym: "NAD+ kinase activator" NARROW [] +synonym: "stimulation of NAD+ kinase activity" NARROW [] +synonym: "up regulation of NAD+ kinase activity" EXACT [] +synonym: "up-regulation of NAD+ kinase activity" EXACT [] +synonym: "upregulation of NAD+ kinase activity" EXACT [] +is_a: GO:0033670 ! regulation of NAD+ kinase activity +is_a: GO:0033674 ! positive regulation of kinase activity + +[Term] +id: GO:0033673 +name: negative regulation of kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] +synonym: "down regulation of kinase activity" EXACT [] +synonym: "down-regulation of kinase activity" EXACT [] +synonym: "downregulation of kinase activity" EXACT [] +synonym: "inhibition of kinase activity" NARROW [] +synonym: "kinase inhibitor" NARROW [] +is_a: GO:0042326 ! negative regulation of phosphorylation +is_a: GO:0043549 ! regulation of kinase activity +is_a: GO:0051348 ! negative regulation of transferase activity + +[Term] +id: GO:0033674 +name: positive regulation of kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] +synonym: "kinase activator" NARROW [] +synonym: "stimulation of kinase activity" NARROW [] +synonym: "up regulation of kinase activity" EXACT [] +synonym: "up-regulation of kinase activity" EXACT [] +synonym: "upregulation of kinase activity" EXACT [] +is_a: GO:0042327 ! positive regulation of phosphorylation +is_a: GO:0043549 ! regulation of kinase activity +is_a: GO:0051347 ! positive regulation of transferase activity + +[Term] +id: GO:0033675 +name: pericanalicular vesicle +namespace: cellular_component +def: "A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." [PMID:15763347, PMID:9790571] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0033677 +name: DNA/RNA helicase activity +namespace: molecular_function +alt_id: GO:0033680 +def: "Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis." [GOC:mah] +synonym: "ATP-dependent DNA/RNA helicase activity" EXACT [] +is_a: GO:0004386 ! helicase activity +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA +is_a: GO:0008186 ! ATP-dependent activity, acting on RNA +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0033678 +name: 5'-3' DNA/RNA helicase activity +namespace: molecular_function +alt_id: GO:0033682 +def: "Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:mah] +synonym: "5' to 3' DNA/RNA helicase activity" EXACT [] +synonym: "ATP-dependent 5' to 3' DNA/RNA helicase activity" EXACT [] +synonym: "ATP-dependent 5'-3' DNA/RNA helicase activity" EXACT [] +xref: Reactome:R-HSA-163120 "Disassociation of Telomerase RNP and the Chromosome End" +is_a: GO:0033677 ! DNA/RNA helicase activity + +[Term] +id: GO:0033679 +name: 3'-5' DNA/RNA helicase activity +namespace: molecular_function +alt_id: GO:0033681 +def: "Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:mah] +synonym: "3' to 5' DNA/RNA helicase activity" EXACT [] +synonym: "ATP-dependent 3' to 5' DNA/RNA helicase activity" EXACT [] +synonym: "ATP-dependent 3'-5' DNA/RNA helicase activity" EXACT [] +is_a: GO:0033677 ! DNA/RNA helicase activity + +[Term] +id: GO:0033683 +name: nucleotide-excision repair, DNA incision +namespace: biological_process +def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound." [GOC:elh, PMID:8631896] +synonym: "DNA incision involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] +synonym: "nucleic acid cleavage involved in nucleotide-excision repair" EXACT [GOC:dph, GOC:tb] +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis +relationship: part_of GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0033684 +name: regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +is_a: GO:0032276 ! regulation of gonadotropin secretion +relationship: regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033685 +name: negative regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +synonym: "down regulation of luteinizing hormone secretion" EXACT [] +synonym: "down-regulation of luteinizing hormone secretion" EXACT [] +synonym: "downregulation of luteinizing hormone secretion" EXACT [] +synonym: "inhibition of luteinizing hormone secretion" NARROW [] +is_a: GO:0032277 ! negative regulation of gonadotropin secretion +is_a: GO:0033684 ! regulation of luteinizing hormone secretion +relationship: negatively_regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033686 +name: positive regulation of luteinizing hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of luteinizing hormone." [GOC:mah] +synonym: "activation of luteinizing hormone secretion" NARROW [] +synonym: "stimulation of luteinizing hormone secretion" NARROW [] +synonym: "up regulation of luteinizing hormone secretion" EXACT [] +synonym: "up-regulation of luteinizing hormone secretion" EXACT [] +synonym: "upregulation of luteinizing hormone secretion" EXACT [] +is_a: GO:0032278 ! positive regulation of gonadotropin secretion +is_a: GO:0033684 ! regulation of luteinizing hormone secretion +relationship: positively_regulates GO:0032275 ! luteinizing hormone secretion + +[Term] +id: GO:0033687 +name: osteoblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:mah] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0033688 +name: regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoblast proliferation." [GOC:mah] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033689 +name: negative regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation." [GOC:mah] +synonym: "down regulation of osteoblast proliferation" EXACT [] +synonym: "down-regulation of osteoblast proliferation" EXACT [] +synonym: "downregulation of osteoblast proliferation" EXACT [] +synonym: "inhibition of osteoblast proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0033688 ! regulation of osteoblast proliferation +relationship: negatively_regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033690 +name: positive regulation of osteoblast proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of osteoblast proliferation." [GOC:mah] +synonym: "activation of osteoblast proliferation" NARROW [] +synonym: "stimulation of osteoblast proliferation" NARROW [] +synonym: "up regulation of osteoblast proliferation" EXACT [] +synonym: "up-regulation of osteoblast proliferation" EXACT [] +synonym: "upregulation of osteoblast proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0033688 ! regulation of osteoblast proliferation +relationship: positively_regulates GO:0033687 ! osteoblast proliferation + +[Term] +id: GO:0033691 +name: sialic acid binding +namespace: molecular_function +def: "Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria." [GOC:add, ISBN:9780721601465] +synonym: "N-acetylneuraminic acid binding" NARROW [] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0033692 +name: cellular polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [GOC:go_curators] +synonym: "cellular glycan biosynthesis" EXACT [] +synonym: "cellular glycan biosynthetic process" EXACT [] +synonym: "cellular polysaccharide anabolism" EXACT [] +synonym: "cellular polysaccharide biosynthesis" EXACT [] +synonym: "cellular polysaccharide formation" EXACT [] +synonym: "cellular polysaccharide synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0033693 +name: neurofilament bundle assembly +namespace: biological_process +def: "The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules." [PMID:11034913, PMID:11264295] +synonym: "NF bundle assembly" EXACT [] +is_a: GO:0045110 ! intermediate filament bundle assembly + +[Term] +id: GO:0033694 +name: oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] +xref: EC:1.5.7.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0033695 +name: oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule." [EC:1.17.5.-, GOC:mah] +xref: EC:1.17.5.- +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033696 +name: heterochromatin boundary formation +namespace: biological_process +alt_id: GO:0031454 +def: "A process that forms a boundary that limits the spreading of heterochromatin along a chromosome." [GOC:mah] +synonym: "maintenance of heterochromatin boundaries" RELATED [] +synonym: "negative regulation of extent of heterochromatin assembly" RELATED [] +synonym: "negative regulation of extent of heterochromatin formation" RELATED [] +synonym: "negative regulation of heterochromatin spreading" RELATED [] +synonym: "regulation of extent of heterochromatin assembly" RELATED [] +synonym: "regulation of extent of heterochromatin formation" EXACT [] +synonym: "regulation of heterochromatin spreading" RELATED [] +is_a: GO:0070828 ! heterochromatin organization +relationship: part_of GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0033697 +name: obsolete positive regulation of extent of heterochromatin assembly +namespace: biological_process +def: "OBSOLETE. Any process that increases the extent of heterochromatin formation; increases the size of a chromosomal region converted to heterochromatin." [GOC:mah] +comment: This term has been obsoleted because there is no evidence it exists. +synonym: "positive regulation of extent of heterochromatin formation" EXACT [] +synonym: "positive regulation of heterochromatin spreading" RELATED [] +is_obsolete: true +consider: GO:0031507 + +[Term] +id: GO:0033698 +name: Rpd3L complex +namespace: cellular_component +alt_id: GO:0000508 +def: "A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae)." [GOC:vw, PMID:17450151] +synonym: "Clr6 histone deacetylase complex I/I'" EXACT [GOC:rb, GOC:vw] +synonym: "Clr6L complex" EXACT [PMID:19040720] +synonym: "Rpd3C(L)" EXACT [] +is_a: GO:0070822 ! Sin3-type complex + +[Term] +id: GO:0033699 +name: DNA 5'-adenosine monophosphate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] +synonym: "AMP-removal activity" RELATED [] +synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] +synonym: "DNA adenylate hydrolysis activity" BROAD [] +synonym: "DNA de-adenylation" RELATED [] +synonym: "DNA deadenylation" RELATED [] +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0033700 +name: phospholipid efflux +namespace: biological_process +def: "The directed movement of a phospholipid out of a cell or organelle." [GOC:mah] +synonym: "phospholipid export" EXACT [] +is_a: GO:0015914 ! phospholipid transport + +[Term] +id: GO:0033701 +name: dTDP-galactose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+." [EC:1.1.1.186] +synonym: "dTDP-D-galactose:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.186] +synonym: "dTDPgalactose 6-dehydrogenase activity" RELATED [EC:1.1.1.186] +synonym: "thymidine-diphosphate-galactose dehydrogenase activity" RELATED [EC:1.1.1.186] +xref: EC:1.1.1.186 +xref: MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN +xref: RHEA:12396 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033702 +name: (+)-trans-carveol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH." [EC:1.1.1.275, RHEA:14825] +synonym: "(+)-trans-carveol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.275] +xref: EC:1.1.1.275 +xref: KEGG_REACTION:R06117 +xref: MetaCyc:RXN-9397 +xref: RHEA:14825 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033703 +name: 3beta-hydroxy-5beta-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH." [EC:1.1.1.277, RHEA:22944] +synonym: "3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.277] +synonym: "3beta-hydroxysteroid 5beta-oxidoreductase activity" RELATED [EC:1.1.1.277] +synonym: "3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity" RELATED [EC:1.1.1.277] +xref: EC:1.1.1.277 +xref: KEGG_REACTION:R06166 +xref: MetaCyc:1.1.1.277-RXN +xref: RHEA:22944 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033704 +name: 3beta-hydroxy-5alpha-steroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH." [EC:1.1.1.278, RHEA:18137] +synonym: "3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.278] +xref: EC:1.1.1.278 +xref: KEGG_REACTION:R07138 +xref: MetaCyc:1.1.1.278-RXN +xref: RHEA:18137 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033705 +name: GDP-4-dehydro-6-deoxy-D-mannose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+." [EC:1.1.1.281] +comment: Note that this enzyme differs from EC:1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). +synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" BROAD [EC:1.1.1.281] +synonym: "GDP-6-deoxy-D-lyxo-4-hexulose reductase activity" RELATED [EC:1.1.1.281] +synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity" RELATED [EC:1.1.1.281] +synonym: "Rmd" RELATED [EC:1.1.1.281] +xref: EC:1.1.1.281 +xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033706 +name: obsolete quinate/shikimate dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+, and shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+." [EC:1.1.1.282] +comment: This term was made obsolete because it represents four reactions, and should be four separate terms. +synonym: "L-quinate:NAD(P)+ 3-oxidoreductase activity" RELATED [EC:1.1.1.282] +synonym: "quinate/shikimate dehydrogenase activity" EXACT [] +synonym: "YdiB" RELATED [EC:1.1.1.282] +is_obsolete: true +consider: GO:0004764 +consider: GO:0030266 +consider: GO:0052733 +consider: GO:0052734 + +[Term] +id: GO:0033707 +name: 3''-deamino-3''-oxonicotianamine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+." [EC:1.1.1.285] +synonym: "2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity" RELATED [EC:1.1.1.285] +xref: EC:1.1.1.285 +xref: MetaCyc:1.1.1.285-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033708 +name: isocitrate-homoisocitrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+." [EC:1.1.1.286] +synonym: "homoisocitrate-isocitrate dehydrogenase activity" RELATED [EC:1.1.1.286] +synonym: "isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.286] +synonym: "PH1722" RELATED [EC:1.1.1.286] +xref: EC:1.1.1.286 +xref: MetaCyc:RXN-7969 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033709 +name: D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+." [EC:1.1.1.287] +synonym: "ARD1p" RELATED [EC:1.1.1.287] +synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] +synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] +synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] +xref: KEGG_REACTION:R07144 +xref: MetaCyc:RXN-7972 +xref: RHEA:11868 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033711 +name: 4-phosphoerythronate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH." [EC:1.1.1.290, RHEA:18829] +synonym: "4-O-phosphoerythronate dehydrogenase activity" RELATED [EC:1.1.1.290] +synonym: "4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.290] +synonym: "4PE dehydrogenase activity" RELATED [EC:1.1.1.290] +synonym: "erythronate-4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.290] +synonym: "PdxB" RELATED [EC:1.1.1.290] +synonym: "PdxB 4PE dehydrogenase activity" RELATED [EC:1.1.1.290] +xref: EC:1.1.1.290 +xref: KEGG_REACTION:R04210 +xref: MetaCyc:ERYTHRON4PDEHYDROG-RXN +xref: RHEA:18829 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033712 +name: 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.292, RHEA:24208] +synonym: "1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.292] +synonym: "AFR" RELATED [EC:1.1.1.292] +xref: EC:1.1.1.292 +xref: KEGG_REACTION:R08194 +xref: MetaCyc:1.1.1.292-RXN +xref: RHEA:24208 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033713 +name: choline:oxygen 1-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide." [EC:1.1.3.17, RHEA:13505] +synonym: "choline oxidase activity" BROAD [EC:1.1.3.17] +xref: EC:1.1.3.17 +xref: MetaCyc:CHOLINE-OXIDASE-RXN +xref: RHEA:13505 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033714 +name: secondary-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + secondary alcohol = H(2)O(2) + ketone." [EC:1.1.3.18, RHEA:23180] +synonym: "polyvinyl alcohol oxidase activity" RELATED [EC:1.1.3.18] +synonym: "secondary alcohol oxidase activity" RELATED [EC:1.1.3.18] +synonym: "secondary-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.18] +xref: EC:1.1.3.18 +xref: KEGG_REACTION:R02277 +xref: MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN +xref: RHEA:23180 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033715 +name: nucleoside oxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O." [EC:1.1.3.28, RHEA:28651] +synonym: "nucleoside:oxygen 5'-oxidoreductase activity" RELATED [EC:1.1.3.28] +xref: EC:1.1.3.28 +xref: MetaCyc:NUCLEOSIDE-OXIDASE-RXN +xref: RHEA:28651 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033716 +name: nucleoside oxidase (hydrogen peroxide-forming) activity +namespace: molecular_function +def: "Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide." [EC:1.1.3.39, RHEA:15489] +comment: Two other reactions might be associated with this activity: (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide. +synonym: "nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity" RELATED [EC:1.1.3.39] +xref: EC:1.1.3.39 +xref: MetaCyc:1.1.3.39-RXN +xref: RHEA:15489 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0033717 +name: gluconate 2-dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor." [EC:1.1.99.3] +synonym: "2-ketogluconate reductase activity" BROAD [EC:1.1.99.3] +synonym: "D-gluconate dehydrogenase activity" RELATED [EC:1.1.99.3] +synonym: "D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity" RELATED [EC:1.1.99.3] +synonym: "D-gluconate:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.3] +synonym: "D-gluconate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.3] +synonym: "gluconate oxidase activity" RELATED [EC:1.1.99.3] +synonym: "gluconic acid dehydrogenase activity" RELATED [EC:1.1.99.3] +synonym: "gluconic dehydrogenase activity" RELATED [EC:1.1.99.3] +xref: EC:1.1.99.3 +xref: MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN +xref: RHEA:12769 +is_a: GO:0008875 ! gluconate dehydrogenase activity + +[Term] +id: GO:0033718 +name: pyranose dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor." [EC:1.1.99.29] +synonym: "PDH" RELATED [EC:1.1.99.29] +synonym: "pyranose dehydrogenase activity" RELATED [EC:1.1.99.29] +synonym: "pyranose-quinone oxidoreductase activity" RELATED [EC:1.1.99.29] +synonym: "pyranose:acceptor oxidoreductase activity" RELATED [EC:1.1.99.29] +synonym: "quinone-dependent pyranose dehydrogenase activity" RELATED [EC:1.1.99.29] +xref: EC:1.1.99.29 +xref: MetaCyc:RXN-7961 +xref: MetaCyc:RXN-7962 +xref: MetaCyc:RXN-7963 +xref: MetaCyc:RXN-7965 +xref: MetaCyc:RXN-7966 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033719 +name: 2-oxo-acid reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor." [EC:1.1.99.30] +synonym: "(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity" RELATED [EC:1.1.99.30] +synonym: "(2R)-hydroxycarboxylate-viologen-oxidoreductase activity" RELATED [EC:1.1.99.30] +synonym: "2-oxoacid reductase activity" RELATED [EC:1.1.99.30] +synonym: "HVOR" RELATED [EC:1.1.99.30] +xref: EC:1.1.99.30 +xref: MetaCyc:1.1.99.30-RXN +xref: RHEA:23664 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033720 +name: (S)-mandelate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor." [EC:1.1.99.31] +synonym: "(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.31] +synonym: "L(+)-mandelate dehydrogenase activity" RELATED [EC:1.1.99.31] +synonym: "MDH" RELATED [EC:1.1.99.31] +xref: EC:1.1.99.31 +xref: MetaCyc:MANDELATE-DEHYDROGENASE-RXN +xref: MetaCyc:MANDELATE-OXY-RXN +xref: RHEA:15749 +xref: UM-BBD_reactionID:r1048 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033721 +name: aldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+." [EC:1.2.1.4] +synonym: "aldehyde:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.4] +synonym: "NADP-acetaldehyde dehydrogenase activity" RELATED [EC:1.2.1.4] +synonym: "NADP-dependent aldehyde dehydrogenase activity" RELATED [EC:1.2.1.4] +xref: EC:1.2.1.4 +xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:11888 +is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0033722 +name: malonate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." [EC:1.2.1.15] +synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.15] +synonym: "malonic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.15] +xref: EC:1.2.1.15 +xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033723 +name: fluoroacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+." [EC:1.2.1.69] +synonym: "fluoroacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.69] +xref: EC:1.2.1.69 +xref: RHEA:16677 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0033726 +name: aldehyde ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.5] +synonym: "aldehyde:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.5] +synonym: "AOR" RELATED [EC:1.2.7.5] +synonym: "tungsten-containing aldehyde ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.5] +xref: EC:1.2.7.5 +xref: MetaCyc:1.2.7.5-RXN +xref: RHEA:16421 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0033727 +name: aldehyde dehydrogenase (FAD-independent) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor." [EC:1.2.99.7] +synonym: "aldehyde oxidoreductase activity" RELATED [EC:1.2.99.7] +synonym: "aldehyde:acceptor oxidoreductase (FAD-independent) activity" RELATED [EC:1.2.99.7] +synonym: "AORDd" RELATED [EC:1.2.99.7] +synonym: "Mop" RELATED [EC:1.2.99.7] +xref: EC:1.2.99.7 +xref: MetaCyc:1.2.99.3-RXN +xref: MetaCyc:1.2.99.7-RXN +xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0033728 +name: divinyl chlorophyllide a 8-vinyl-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+." [EC:1.3.1.75] +synonym: "4VCR" RELATED [EC:1.3.1.75] +synonym: "[4-vinyl]chlorophyllide a reductase activity" RELATED [EC:1.3.1.75] +synonym: "chlorophyllide-a:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.75] +xref: EC:1.3.1.75 +xref: MetaCyc:RXN-5286 +xref: RHEA:14449 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033729 +name: anthocyanidin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+." [EC:1.3.1.77] +synonym: "ANR" RELATED [EC:1.3.1.77] +synonym: "AtANR" RELATED [EC:1.3.1.77] +synonym: "flavan-3-ol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.3.1.77] +synonym: "MtANR" RELATED [EC:1.3.1.77] +xref: EC:1.3.1.77 +xref: MetaCyc:1.3.1.77-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033730 +name: arogenate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2." [EC:1.3.1.78] +synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.78] +synonym: "L-arogenate:NADP+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.3.1.78] +synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.78] +synonym: "TyrAa" RELATED [EC:1.3.1.78] +synonym: "TyrAAT1" RELATED [EC:1.3.1.78] +synonym: "TyrAAT2" RELATED [EC:1.3.1.78] +xref: EC:1.3.1.78 +xref: MetaCyc:1.3.1.78-RXN +xref: RHEA:15417 +is_a: GO:0033731 ! arogenate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0033731 +name: arogenate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2." [EC:1.3.1.79] +synonym: "arogenic dehydrogenase activity" BROAD [EC:1.3.1.79] +synonym: "L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity" RELATED [EC:1.3.1.79] +synonym: "pretyrosine dehydrogenase activity" BROAD [EC:1.3.1.79] +xref: EC:1.3.1.79 +xref: MetaCyc:1.3.1.79-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033732 +name: pyrroloquinoline-quinone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone." [EC:1.3.3.11, RHEA:10692] +synonym: "6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity" RELATED [EC:1.3.3.11] +synonym: "PqqC" RELATED [EC:1.3.3.11] +xref: EC:1.3.3.11 +xref: KEGG_REACTION:R07353 +xref: MetaCyc:1.3.3.11-RXN +xref: RHEA:10692 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0033734 +name: (R)-benzylsuccinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein." [EC:1.3.8.3] +synonym: "(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity" RELATED [EC:1.3.8.3] +synonym: "(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.3.8.3] +synonym: "BbsG" RELATED [EC:1.3.8.3] +xref: EC:1.3.8.3 +xref: RHEA:20876 +xref: UM-BBD_reactionID:r0330 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0033735 +name: aspartate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+." [EC:1.4.1.21] +synonym: "L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity" RELATED [EC:1.4.1.21] +synonym: "NAD-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21] +synonym: "NADH2-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21] +synonym: "NADP+-dependent aspartate dehydrogenase activity" RELATED [EC:1.4.1.21] +xref: EC:1.4.1.21 +xref: KEGG_REACTION:R07164 +xref: KEGG_REACTION:R07165 +xref: MetaCyc:1.4.1.21-RXN +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0033736 +name: L-lysine 6-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+)." [EC:1.4.3.20, RHEA:22548] +synonym: "L-lysine-epsilon-oxidase activity" RELATED [EC:1.4.3.20] +synonym: "L-lysine:oxygen 6-oxidoreductase (deaminating) activity" RELATED [EC:1.4.3.20] +synonym: "Lod" RELATED [EC:1.4.3.20] +synonym: "LodA" RELATED [EC:1.4.3.20] +synonym: "marinocine" RELATED [EC:1.4.3.20] +xref: EC:1.4.3.20 +xref: KEGG_REACTION:R07598 +xref: MetaCyc:1.4.3.20-RXN +xref: RHEA:22548 +is_a: GO:0001716 ! L-amino-acid oxidase activity + +[Term] +id: GO:0033737 +name: 1-pyrroline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+." [MetaCyc:1.5.1.35-RXN] +synonym: "1-pyrroline:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.35] +synonym: "ABALDH" RELATED [EC:1.5.1.35] +synonym: "gamma-aminobutyraldehyde dehydrogenase activity" RELATED [EC:1.5.1.35] +synonym: "YdcW" RELATED [EC:1.5.1.35] +xref: EC:1.2.1.19 +xref: MetaCyc:1.5.1.35-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0033738 +name: methylenetetrahydrofolate reductase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin." [EC:1.5.7.1] +synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.7.1] +synonym: "5-methyltetrahydrofolate:ferredoxin oxidoreductase activity" RELATED [EC:1.5.7.1] +xref: EC:1.5.7.1 +xref: MetaCyc:RXN-5061 +xref: RHEA:14229 +is_a: GO:0033694 ! oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0033739 +name: preQ1 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH." [EC:1.7.1.13, RHEA:13409] +synonym: "7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.7.1.13] +synonym: "7-cyano-7-deazaguanine reductase activity" RELATED [EC:1.7.1.13] +synonym: "preQ0 oxidoreductase activity" RELATED [EC:1.7.1.13] +synonym: "preQ0 reductase activity" RELATED [EC:1.7.1.13] +synonym: "QueF" RELATED [EC:1.7.1.13] +synonym: "queuine synthase activity" RELATED [] +synonym: "queuine:NADP+ oxidoreductase activity" RELATED [] +synonym: "YkvM" RELATED [EC:1.7.1.13] +xref: EC:1.7.1.13 +xref: KEGG_REACTION:R07605 +xref: MetaCyc:RXN0-4022 +xref: RHEA:13409 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0033740 +name: hydroxylamine oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor." [EC:1.7.2.8] +synonym: "hydroxylamine:acceptor oxidoreductase activity" RELATED [EC:1.7.2.8] +xref: EC:1.7.2.8 +xref: MetaCyc:1.7.99.8-RXN +xref: RHEA:23232 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033741 +name: adenylyl-sulfate reductase (glutathione) activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione." [EC:1.8.4.9, RHEA:14141] +synonym: "5'-adenylylsulfate reductase activity" RELATED [EC:1.8.4.9] +synonym: "AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" RELATED [EC:1.8.4.9] +synonym: "AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity" RELATED [EC:1.8.4.9] +synonym: "plant-type 5'-adenylylsulfate reductase activity" NARROW [EC:1.8.4.9] +xref: EC:1.8.4.9 +xref: KEGG_REACTION:R05717 +xref: MetaCyc:1.8.4.9-RXN +xref: RHEA:14141 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033743 +name: peptide-methionine (R)-S-oxide reductase activity +namespace: molecular_function +alt_id: GO:0000318 +def: "Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.12, GOC:mah, GOC:vw, RHEA:24164] +synonym: "methionine S-oxide reductase (R-form oxidizing) activity" RELATED [EC:1.8.4.12] +synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.12] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.12] +synonym: "methionine sulfoxide reductase B activity" NARROW [EC:1.8.4.12] +synonym: "MsrB" RELATED [EC:1.8.4.12] +synonym: "peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity" RELATED [EC:1.8.4.12] +synonym: "PilB" RELATED [EC:1.8.4.12] +synonym: "pMRsr" RELATED [EC:1.8.4.12] +synonym: "pMSR" RELATED [EC:1.8.4.12] +synonym: "protein-methionine-R-oxide reductase activity" EXACT [] +synonym: "selenoprotein R" RELATED [EC:1.8.4.12] +synonym: "SelR" RELATED [EC:1.8.4.12] +synonym: "SelX" RELATED [EC:1.8.4.12] +xref: EC:1.8.4.12 +xref: KEGG_REACTION:R07607 +xref: MetaCyc:1.8.4.12-RXN +xref: Reactome:R-HSA-5676917 "MRSBs reduce L-methyl-(R)-S-oxide to L-methionine" +xref: RHEA:24164 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033744 +name: L-methionine:thioredoxin-disulfide S-oxidoreductase activity +namespace: molecular_function +alt_id: GO:0000317 +def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.13] +synonym: "acetylmethionine sulfoxide reductase activity" RELATED [EC:1.8.4.13] +synonym: "free-methionine (S)-S-oxide reductase activity" RELATED [EC:1.8.4.13] +synonym: "fSMsr" RELATED [EC:1.8.4.13] +synonym: "L-methionine-(S)-S-oxide reductase activity" NARROW [GOC:bf, GOC:vw] +synonym: "L-methionine:oxidized-thioredoxin S-oxidoreductase activity" RELATED [EC:1.8.4.13] +synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.13] +synonym: "methionine-S-oxide reductase activity" EXACT [PMID:11169920] +synonym: "methyl sulfoxide reductase I and II activity" RELATED [EC:1.8.4.13] +xref: EC:1.8.4.13 +xref: KEGG_REACTION:R07606 +xref: MetaCyc:1.8.4.13-RXN +xref: RHEA:19993 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033745 +name: L-methionine-(R)-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin." [EC:1.8.4.14] +synonym: "free met-R-(o) reductase activity" RELATED [EC:1.8.4.14] +synonym: "free-methionine (R)-S-oxide reductase activity" RELATED [EC:1.8.4.14] +synonym: "FRMsr" RELATED [EC:1.8.4.14] +synonym: "L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity" RELATED [EC:1.8.4.14] +xref: EC:1.8.4.14 +xref: MetaCyc:1.8.4.14-RXN +xref: RHEA:21260 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0033746 +name: histone H3-methyl-arginine-2 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579, PMID:22483719, PMID:29233856] +synonym: "histone demethylase activity (H3-R2 specific)" EXACT [] +synonym: "histone H3R2me demethylase activity" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0033747 +name: obsolete versatile peroxidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: Reactive Black 5 + hydrogen peroxide = oxidized Reactive Black 5 + 2 H2O, and donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.16] +synonym: "hybrid peroxidase activity" RELATED [EC:1.11.1.16] +synonym: "polyvalent peroxidase activity" RELATED [EC:1.11.1.16] +synonym: "reactive-black-5:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.16] +synonym: "versatile peroxidase activity" EXACT [] +synonym: "VP" RELATED [EC:1.11.1.16] +is_obsolete: true +replaced_by: GO:0004601 +consider: GO:0052750 + +[Term] +id: GO:0033748 +name: hydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + A = AH2." [EC:1.12.99.6] +synonym: "H2 producing hydrogenase activity" BROAD [EC:1.12.99.6] +synonym: "hydrogen-lyase activity" BROAD [EC:1.12.99.6] +synonym: "hydrogen:(acceptor) oxidoreductase activity" RELATED [EC:1.12.99.6] +synonym: "hydrogen:acceptor oxidoreductase activity" RELATED [EC:1.12.99.6] +synonym: "hydrogenlyase activity" BROAD [EC:1.12.99.6] +synonym: "uptake hydrogenase activity" BROAD [EC:1.12.99.6] +xref: EC:1.12.99.6 +xref: MetaCyc:RXN0-4141 +xref: MetaCyc:RXN0-5256 +xref: RHEA:12116 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0033749 +name: histone H3-methyl-arginine-3 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17947579] +synonym: "histone demethylase activity (H4-R3 specific)" EXACT [] +synonym: "histone H3R3me demethylase activity" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0033750 +name: ribosome localization +namespace: biological_process +alt_id: GO:0033753 +def: "A process in which a ribosome is transported to, and/or maintained in, a specific location." [GOC:mah] +synonym: "establishment of ribosome localisation" RELATED [] +synonym: "establishment of ribosome localization" RELATED [] +synonym: "ribosome localisation" RELATED [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0033751 +name: obsolete linoleate 8R-lipoxygenase +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate." [GOC:curators] +comment: The reason for obsoletion is because there is no support for the reaction. EC and RHEA mappings have been obsoleted at their source. +synonym: "5,8-linoleate diol synthase (bifunctional enzyme)" RELATED [] +synonym: "7,8-linoleate diol synthase (bifunctional enzyme)" RELATED [] +synonym: "linoleate diol synthase activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0033752 +name: acetylacetone-cleaving enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal." [EC:1.13.11.50] +synonym: "acetylacetone dioxygenase activity" RELATED [EC:1.13.11.50] +synonym: "acetylacetone-cleaving enzyme" RELATED [EC:1.13.11.50] +synonym: "acetylacetone:oxygen oxidoreductase activity" RELATED [EC:1.13.11.50] +synonym: "diketone cleaving dioxygenase activity" RELATED [EC:1.13.11.50] +synonym: "diketone cleaving enzyme" RELATED [EC:1.13.11.50] +synonym: "Dke1" RELATED [EC:1.13.11.50] +xref: EC:1.13.11.50 +xref: RHEA:12877 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033754 +name: indoleamine 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine." [EC:1.13.11.52] +synonym: "D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity" NARROW [EC:1.13.11.52] +synonym: "IDO" RELATED [EC:1.13.11.52] +synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.52] +xref: EC:1.13.11.52 +xref: MetaCyc:RXN-8664 +xref: MetaCyc:RXN-8665 +xref: RHEA:14189 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033755 +name: sulfur oxygenase/reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." [EC:1.13.11.55] +synonym: "SOR" RELATED [EC:1.13.11.55] +synonym: "sulfur oxygenase activity" BROAD [EC:1.13.11.55] +synonym: "sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity" RELATED [EC:1.13.11.55] +synonym: "sulphur oxygenase/reductase activity" EXACT [] +xref: EC:1.13.11.55 +xref: MetaCyc:1.13.11.55-RXN +xref: RHEA:13957 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0033756 +name: Oplophorus-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu." [EC:1.13.12.13] +synonym: "Oplophorus luciferase activity" RELATED [EC:1.13.12.13] +synonym: "Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity" RELATED [EC:1.13.12.13] +xref: EC:1.13.12.13 +xref: MetaCyc:RXN-3361 +xref: RHEA:20417 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0033757 +name: glucoside 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor." [EC:1.1.99.13] +synonym: "D-aldohexopyranoside dehydrogenase" RELATED [EC:1.1.99.13] +synonym: "D-aldohexoside:(acceptor) 3-oxidoreductase" RELATED [EC:1.1.99.13] +synonym: "D-aldohexoside:acceptor 3-oxidoreductase" RELATED [EC:1.1.99.13] +synonym: "D-aldohexoside:cytochrome c oxidoreductase" RELATED [EC:1.1.99.13] +synonym: "hexopyranoside-cytochrome c oxidoreductase" RELATED [EC:1.1.99.13] +xref: EC:1.1.99.13 +xref: MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN +xref: RHEA:16589 +xref: Wikipedia:Glucoside_3-dehydrogenase +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0033758 +name: clavaminate synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O." [EC:1.14.11.21] +synonym: "clavaminate synthase 2 activity" NARROW [EC:1.14.11.21] +synonym: "clavaminic acid synthase activity" RELATED [EC:1.14.11.21] +synonym: "deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.21] +xref: EC:1.14.11.21 +xref: MetaCyc:1.14.11.21-RXN +xref: RHEA:20021 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0033759 +name: flavone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O." [EC:1.14.20.5] +synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity" RELATED [EC:1.14.20.5] +synonym: "flavone synthase I activity" RELATED [EC:1.14.20.5] +synonym: "FNS I" RELATED [EC:1.14.20.5] +xref: EC:1.14.20.5 +xref: MetaCyc:RXN-8000 +xref: RHEA:10448 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0033760 +name: 2'-deoxymugineic-acid 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate." [EC:1.14.11.24, RHEA:12200] +synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity" RELATED [EC:1.14.11.24] +synonym: "IDS3" RELATED [EC:1.14.11.24] +xref: EC:1.14.11.24 +xref: KEGG_REACTION:R07185 +xref: MetaCyc:1.14.11.24-RXN +xref: RHEA:12200 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0033761 +name: mugineic-acid 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2." [EC:1.14.11.25] +synonym: "IDS2" RELATED [EC:1.14.11.25] +synonym: "mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.25] +xref: EC:1.14.11.25 +xref: KEGG_REACTION:R07186 +xref: MetaCyc:RXN-7982 +xref: RHEA:14509 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0033762 +name: response to glucagon +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:sl] +synonym: "response to glucagon stimulus" EXACT [GOC:dos] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0033763 +name: proline 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.28] +synonym: "L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.28] +synonym: "P-3-H" RELATED [EC:1.14.11.28] +xref: EC:1.14.11.28 +xref: MetaCyc:1.14.11.28-RXN +xref: RHEA:20265 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0033764 +name: steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative." [GOC:mah] +is_a: GO:0016229 ! steroid dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033765 +name: steroid dehydrogenase activity, acting on the CH-CH group of donors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative." [GOC:mah] +is_a: GO:0016229 ! steroid dehydrogenase activity +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0033766 +name: 2-hydroxyquinoline 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol." [EC:1.14.13.61, RHEA:22080] +synonym: "2-oxo-1,2-dihydroquinoline 8-monooxygenase activity" RELATED [EC:1.14.13.61] +synonym: "quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity" RELATED [EC:1.14.13.61] +xref: EC:1.14.13.61 +xref: KEGG_REACTION:R05158 +xref: MetaCyc:1.14.13.61-RXN +xref: RHEA:22080 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033767 +name: 4-hydroxyacetophenone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4'-hydroxyacetophenone + H(+) + NADPH + O(2) = 4-hydroxyphenyl acetate + H(2)O + NADP(+)." [EC:1.14.13.84, RHEA:22916] +synonym: "(4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity" EXACT systematic_synonym [EC:1.14.13.84] +synonym: "HAPMO" RELATED [EC:1.14.13.84] +xref: EC:1.14.13.84 +xref: KEGG_REACTION:R06892 +xref: MetaCyc:1.14.13.84-RXN +xref: RHEA:22916 +xref: UM-BBD_reactionID:r0756 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033768 +name: SUMO-targeted ubiquitin ligase complex +namespace: cellular_component +def: "A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes." [GOC:vw, PMID:17762864, PMID:17762865] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0033769 +name: glyceollin synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O." [EC:1.14.13.85] +synonym: "2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity" RELATED [EC:1.14.13.85] +synonym: "dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity" RELATED [EC:1.14.13.85] +xref: EC:1.14.13.85 +xref: MetaCyc:2.5.1.36-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033770 +name: 2-hydroxyisoflavanone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O." [EC:1.14.13.86] +synonym: "2-HIS" RELATED [EC:1.14.13.86] +synonym: "apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity" RELATED [EC:1.14.13.86] +xref: EC:1.14.13.86 +xref: MetaCyc:RXN-7750 +xref: RHEA:14897 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033771 +name: licodione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+)." [EC:1.14.14.140, RHEA:15697] +synonym: "(2S)-flavanone 2-hydroxylase activity" RELATED [EC:1.14.14.140] +synonym: "liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity" RELATED [EC:1.14.14.140] +xref: EC:1.14.14.140 +xref: KEGG_REACTION:R07198 +xref: MetaCyc:1.14.13.87-RXN +xref: RHEA:15697 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033772 +name: flavonoid 3',5'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O." [EC:1.14.14.81] +synonym: "F3',5'H" RELATED [EC:1.14.14.81] +synonym: "F3'5'H" RELATED [EC:1.14.14.81] +synonym: "flavanone,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.81] +xref: EC:1.14.14.81 +xref: MetaCyc:RXN-7783 +xref: MetaCyc:RXN-8671 +xref: RHEA:55448 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033773 +name: isoflavone 2'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [RHEA:18849] +comment: Formerly EC:1.14.13.89. +synonym: "CYP Ge-3" RELATED [EC:1.14.14.90] +synonym: "CYP81E1" RELATED [EC:1.14.14.90] +synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.14.90] +xref: EC:1.14.14.90 +xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN +xref: RHEA:18849 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033774 +name: basal labyrinth +namespace: cellular_component +def: "A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane." [GOC:mah, GOC:sart, PMID:11640882] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0033775 +name: deoxysarpagine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine." [EC:1.14.14.136, RHEA:14237] +synonym: "10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity" RELATED [EC:1.14.14.136] +synonym: "DOSH" RELATED [EC:1.14.14.136] +xref: EC:1.14.14.136 +xref: KEGG_REACTION:R05828 +xref: MetaCyc:1.14.13.91-RXN +xref: RHEA:14237 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033776 +name: phenylacetone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+)." [EC:1.14.13.92, RHEA:10124] +synonym: "PAMO" RELATED [EC:1.14.13.92] +synonym: "phenylacetone,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.92] +xref: EC:1.14.13.92 +xref: KEGG_REACTION:R07201 +xref: MetaCyc:1.14.13.92-RXN +xref: RHEA:10124 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033777 +name: lithocholate 6beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+)." [EC:1.14.14.138, RHEA:18857] +synonym: "6beta-hydroxylase activity" BROAD [EC:1.14.14.138] +synonym: "CYP3A10" RELATED [EC:1.14.14.138] +synonym: "cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity" RELATED [EC:1.14.14.138] +synonym: "lithocholate 6beta-monooxygenase activity" RELATED [EC:1.14.14.138] +synonym: "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity" RELATED [EC:1.14.14.138] +xref: EC:1.14.14.138 +xref: KEGG_REACTION:R07203 +xref: MetaCyc:1.14.13.94-RXN +xref: RHEA:18857 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033778 +name: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+)." [PMID:10051404, PMID:1400444, RHEA:46752] +synonym: "7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity" RELATED [EC:1.14.13.95] +synonym: "7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" RELATED [EC:1.14.13.95] +synonym: "CYP12" RELATED [EC:1.14.13.95] +synonym: "HCO 12alpha-hydroxylase activity" RELATED [EC:1.14.13.95] +synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.13.95] +xref: EC:1.14.14.139 +xref: KEGG_REACTION:R04826 +xref: MetaCyc:1.14.13.95-RXN +xref: Reactome:R-HSA-192157 "CYP8B1 12-hydroxylates 4CHOL7aOLONE" +xref: Reactome:R-HSA-193709 "CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL" +xref: Reactome:R-HSA-193845 "CYP8B1 12-hydroxylates 4CHOL7a,27DONE" +xref: RHEA:10504 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033779 +name: 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+)." [EC:1.14.14.139, RHEA:15261] +synonym: "5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity" RELATED [EC:1.14.14.139] +synonym: "5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity" RELATED [EC:1.14.14.139] +synonym: "CYP8B1" RELATED [EC:1.14.14.139] +synonym: "cytochrome P450 8B1" RELATED [EC:1.14.14.139] +synonym: "sterol 12alpha-hydroxylase activity" BROAD [EC:1.14.14.139] +xref: EC:1.14.14.139 +xref: KEGG_REACTION:R07204 +xref: MetaCyc:1.14.13.96-RXN +xref: RHEA:15261 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033780 +name: taurochenodeoxycholate 6alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." [EC:1.14.13.97] +synonym: "CYP3A4" RELATED [EC:1.14.13.97] +synonym: "CYP4A21" RELATED [EC:1.14.13.97] +synonym: "taurochenodeoxycholate 6alpha-monooxygenase activity" RELATED [EC:1.14.13.97] +synonym: "taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity" RELATED [EC:1.14.13.97] +xref: EC:1.14.13.97 +xref: MetaCyc:RXN-7977 +xref: RHEA:23644 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033781 +name: cholesterol 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+)." [EC:1.14.14.25, RHEA:22716] +synonym: "cholesterol 24-monooxygenase activity" RELATED [EC:1.14.14.25] +synonym: "cholesterol 24S-hydroxylase activity" RELATED [EC:1.14.14.25] +synonym: "cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity" RELATED [EC:1.14.14.25] +synonym: "CYP46" RELATED [EC:1.14.14.25] +synonym: "CYP46A1" RELATED [EC:1.14.14.25] +synonym: "cytochrome P450 46A1" RELATED [EC:1.14.14.25] +xref: EC:1.14.14.25 +xref: KEGG_REACTION:R07207 +xref: MetaCyc:1.14.13.98-RXN +xref: Reactome:R-HSA-192061 "CYP46A1 24-hydroxylates CHOL" +xref: RHEA:22716 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033782 +name: 24-hydroxycholesterol 7alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:10748047, PMID:11013305, RHEA:46124] +comment: Formerly EC:1.14.13.99. +synonym: "24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [] +synonym: "24-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.26] +xref: EC:1.14.14.26 +xref: KEGG_REACTION:R07208 +xref: MetaCyc:1.14.13.99-RXN +xref: RHEA:46124 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033783 +name: 25-hydroxycholesterol 7alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O." [EC:1.14.14.29] +synonym: "25-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.29] +synonym: "cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity" RELATED [EC:1.14.14.29] +synonym: "CYP7B1" RELATED [EC:1.14.14.29] +synonym: "CYP7B1 oxysterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.29] +xref: EC:1.14.14.29 +xref: MetaCyc:RXN-7980 +xref: MetaCyc:RXN-7981 +xref: RHEA:19041 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033784 +name: senecionine N-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide." [EC:1.14.13.101, RHEA:11420] +synonym: "senecionine monooxygenase (N-oxide-forming) activity" RELATED [EC:1.14.13.101] +synonym: "senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity" RELATED [EC:1.14.13.101] +synonym: "SNO" RELATED [EC:1.14.13.101] +xref: EC:1.14.13.101 +xref: KEGG_REACTION:R07373 +xref: MetaCyc:1.14.13.101-RXN +xref: RHEA:11420 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0033785 +name: heptose 7-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP." [RHEA:27473] +synonym: "D-alpha,beta-D-heptose 7-phosphate 1-kinase activity" EXACT [] +xref: EC:2.7.1.167 +xref: MetaCyc:RXN0-4341 +xref: RHEA:27473 +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033786 +name: heptose-1-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose." [MetaCyc:RXN0-4342] +synonym: "D-beta-D-heptose 1-phosphate adenylyltransferase activity" EXACT [] +synonym: "heptose 1-phosphate adenyltransferase activity" EXACT [] +xref: MetaCyc:RXN0-4342 +xref: RHEA:27465 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0033787 +name: cyanocobalamin reductase (cyanide-eliminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH." [RHEA:16113] +comment: Formerly EC:1.6.99.12. +synonym: "cob(I)alamin, cyanide:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.6] +synonym: "cyanocobalamin reductase (NADPH, cyanide-eliminating) activity" RELATED [EC:1.16.1.6] +synonym: "cyanocobalamin reductase (NADPH; CN-eliminating) activity" RELATED [EC:1.16.1.6] +synonym: "cyanocobalamin reductase activity" RELATED [EC:1.16.1.6] +synonym: "NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" RELATED [EC:1.16.1.6] +synonym: "NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity" RELATED [EC:1.16.1.6] +xref: EC:1.16.1.6 +xref: KEGG_REACTION:R02999 +xref: MetaCyc:1.6.99.12-RXN +xref: Reactome:R-HSA-3149519 "MMACHC decyanates CNCbl" +xref: RHEA:16113 +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0033788 +name: leucoanthocyanidin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+." [EC:1.17.1.3] +synonym: "(2R,3S)-catechin:NADP+ 4-oxidoreductase activity" RELATED [EC:1.17.1.3] +synonym: "leucocyanidin reductase activity" RELATED [EC:1.17.1.3] +xref: EC:1.17.1.3 +xref: MetaCyc:RXN-1484 +xref: RHEA:10616 +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0033789 +name: phenylacetyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA." [RHEA:15705] +synonym: "phenylacetyl-CoA:acceptor oxidoreductase activity" RELATED [EC:1.17.5.1] +synonym: "phenylacetyl-CoA:quinone oxidoreductase activity" RELATED [EC:1.17.5.1] +xref: EC:1.17.5.1 +xref: KEGG_REACTION:R07222 +xref: MetaCyc:1.17.5.1-RXN +xref: RHEA:15705 +is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor + +[Term] +id: GO:0033790 +name: hydroxymethylfurfural reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033791 +name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor." [EC:1.17.99.3] +synonym: "(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity" RELATED [EC:1.17.99.3] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity" RELATED [EC:1.17.99.3] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity" RELATED [EC:1.17.99.3] +synonym: "THC-CoA oxidase activity" RELATED [EC:1.17.99.3] +synonym: "THCA-CoA oxidase activity" RELATED [EC:1.17.99.3] +synonym: "trihydroxycoprostanoyl-CoA oxidase activity" RELATED [EC:1.17.99.3] +xref: EC:1.17.99.3 +xref: MetaCyc:1.17.99.3-RXN +xref: RHEA:15733 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033792 +name: bile-acid 7alpha-dehydroxylase activity +namespace: molecular_function +def: "Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2, and lithocholate + FAD + H2O = chenodeoxycholate + FADH2." [EC:1.17.99.5] +synonym: "7alpha-dehydroxylase activity" RELATED [EC:1.17.99.5] +synonym: "bile acid 7-dehydroxylase activity" RELATED [EC:1.17.99.5] +synonym: "cholate 7alpha-dehydroxylase activity" RELATED [EC:1.17.99.5] +synonym: "deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity" RELATED [EC:1.17.99.5] +synonym: "deoxycholate:NAD+ oxidoreductase activity" RELATED [EC:1.17.99.5] +xref: EC:1.17.99.5 +xref: MetaCyc:RXN-8658 +xref: MetaCyc:RXN-8659 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0033793 +name: aureusidin synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O." [EC:1.21.3.6] +synonym: "2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity" RELATED [EC:1.21.3.6] +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0033794 +name: sarcosine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin." [EC:1.21.4.3] +synonym: "acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity" RELATED [EC:1.21.4.3] +xref: EC:1.21.4.3 +xref: RHEA:12825 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0033795 +name: betaine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin." [EC:1.21.4.4] +synonym: "acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity" RELATED [EC:1.21.4.4] +xref: EC:1.21.4.4 +xref: RHEA:11848 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0033796 +name: sulfur reductase activity +namespace: molecular_function +def: "Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide." [EC:1.12.98.4] +synonym: "(donor):sulfur oxidoreductase activity" RELATED [EC:1.12.98.4] +synonym: "sulphur reductase activity" EXACT [] +xref: EC:1.12.98.4 +xref: MetaCyc:1.97.1.3-RXN +xref: MetaCyc:RXN-8269 +xref: RHEA:35591 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033797 +name: selenate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite." [EC:1.97.1.9, RHEA:14029] +synonym: "selenite:reduced acceptor oxidoreductase activity" RELATED [EC:1.97.1.9] +xref: EC:1.97.1.9 +xref: KEGG_REACTION:R07229 +xref: MetaCyc:RXN0-2101 +xref: RHEA:14029 +xref: UM-BBD_reactionID:r0828 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033798 +name: thyroxine 5-deiodinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2." [EC:1.21.99.3] +synonym: "acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity" RELATED [EC:1.21.99.3] +synonym: "diiodothyronine 5'-deiodinase activity" BROAD [EC:1.21.99.3] +synonym: "inner ring-deiodinating pathway" EXACT [PMID:20403357] +synonym: "iodothyronine 5-deiodinase activity" RELATED [EC:1.21.99.3] +synonym: "iodothyronine inner ring monodeiodinase activity" RELATED [EC:1.21.99.3] +synonym: "type III iodothyronine deiodinase activity" NARROW [EC:1.21.99.3] +xref: EC:1.21.99.3 +xref: MetaCyc:1.97.1.11-RXN +xref: RHEA:18897 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0033799 +name: myricetin 3'-O-methyltransferase activity +namespace: molecular_function +alt_id: GO:0102437 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin." [RHEA:25629] +comment: Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267 +synonym: "CrCOMT2" RELATED [] +synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [] +synonym: "myricetin 3-O-methyltransferase activity" RELATED [] +synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [] +xref: EC:2.1.1.267; +xref: KEGG_REACTION:R06815 +xref: MetaCyc:RXN-13912 +xref: MetaCyc:RXN-8451 +xref: RHEA:25629 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033800 +name: isoflavone 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone." [EC:2.1.1.150] +synonym: "S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity" RELATED [EC:2.1.1.150] +xref: EC:2.1.1.150 +xref: MetaCyc:RXN-6241 +xref: RHEA:17933 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033801 +name: vitexin 2''-O-rhamnoside 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside." [EC:2.1.1.153] +synonym: "S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity" RELATED [EC:2.1.1.153] +xref: EC:2.1.1.153 +xref: MetaCyc:RXN-4981 +xref: RHEA:11432 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033802 +name: isoliquiritigenin 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.154, RHEA:21608] +synonym: "chalcone OMT" RELATED [EC:2.1.1.154] +synonym: "CHMT" RELATED [EC:2.1.1.154] +synonym: "S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity" RELATED [EC:2.1.1.154] +xref: EC:2.1.1.154 +xref: KEGG_REACTION:R07242 +xref: MetaCyc:RXN-3501 +xref: RHEA:21608 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033803 +name: kaempferol 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide." [EC:2.1.1.155, RHEA:15105] +synonym: "F 4'-OMT" RELATED [EC:2.1.1.155] +synonym: "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity" RELATED [EC:2.1.1.155] +synonym: "S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.155] +xref: EC:2.1.1.155 +xref: KEGG_REACTION:R06807 +xref: MetaCyc:2.1.1.155-RXN +xref: RHEA:15105 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0033804 +name: obsolete glycine/sarcosine N-methyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine, and S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.156] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "ApGSMT" RELATED [EC:2.1.1.156] +synonym: "glycine sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.156] +synonym: "glycine-sarcosine methyltransferase activity" RELATED [EC:2.1.1.156] +synonym: "glycine/sarcosine N-methyltransferase activity" EXACT [] +synonym: "GMT" RELATED [EC:2.1.1.156] +synonym: "GSMT" RELATED [EC:2.1.1.156] +synonym: "S-adenosyl-L-methionine:sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.156] +is_obsolete: true +consider: GO:0017174 +consider: GO:0052730 + +[Term] +id: GO:0033805 +name: obsolete sarcosine/dimethylglycine N-methyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine, and S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "ApDMT" RELATED [EC:2.1.1.157] +synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157] +synonym: "sarcosine dimethylglycine methyltransferase activity" NARROW [EC:2.1.1.157] +synonym: "sarcosine dimethylglycine N-methyltransferase activity" NARROW [EC:2.1.1.157] +synonym: "sarcosine/dimethylglycine N-methyltransferase activity" EXACT [] +synonym: "SDMT" RELATED [EC:2.1.1.157] +is_obsolete: true +consider: GO:0052729 +consider: GO:0052730 + +[Term] +id: GO:0033806 +name: fluorothreonine transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine." [RHEA:11748] +synonym: "fluoroacetaldehyde:L-threonine aldehydetransferase activity" RELATED [EC:2.2.1.8] +xref: EC:2.2.1.8 +xref: RHEA:11748 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0033807 +name: icosanoyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+." [EC:2.3.1.119] +synonym: "acyl-CoA elongase activity" RELATED [EC:2.3.1.119] +synonym: "C18-CoA elongase activity" RELATED [EC:2.3.1.119] +synonym: "stearoyl-CoA elongase activity" RELATED [EC:2.3.1.119] +synonym: "stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity" RELATED [EC:2.3.1.119] +xref: EC:2.3.1.119 +xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033808 +name: 6'-deoxychalcone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O." [EC:2.3.1.170] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity" RELATED [EC:2.3.1.170] +xref: EC:2.3.1.170 +xref: MetaCyc:RXN-3142 +xref: RHEA:10584 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033809 +name: anthocyanin 6''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside)." [EC:2.3.1.171] +synonym: "3MaT" RELATED [EC:2.3.1.171] +synonym: "Dv3MaT" RELATED [EC:2.3.1.171] +synonym: "malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.171] +synonym: "malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.171] +xref: EC:2.3.1.171 +xref: MetaCyc:2.3.1.171-RXN +xref: RHEA:16025 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033810 +name: anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin." [EC:2.3.1.172] +synonym: "malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity" RELATED [EC:2.3.1.172] +synonym: "Ss5MaT1" RELATED [EC:2.3.1.172] +xref: EC:2.3.1.172 +xref: MetaCyc:2.3.1.172-RXN +xref: RHEA:21988 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033811 +name: flavonol-3-O-triglucoside O-coumaroyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]." [EC:2.3.1.173] +synonym: "4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity" RELATED [EC:2.3.1.173] +xref: EC:2.3.1.173 +xref: MetaCyc:2.3.1.173-RXN +xref: RHEA:22160 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033812 +name: 3-oxoadipyl-CoA thiolase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA." [EC:2.3.1.174] +synonym: "succinyl-CoA:acetyl-CoA C-succinyltransferase activity" RELATED [EC:2.3.1.174] +xref: EC:2.3.1.174 +xref: MetaCyc:RXN-3641 +xref: RHEA:19481 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033813 +name: deacetylcephalosporin-C acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA." [EC:2.3.1.175, RHEA:23860] +synonym: "acetyl coenzyme A:DAC acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "acetyl-CoA:DAC acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "acetyl-CoA:DAC O-acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "cefG" RELATED [EC:2.3.1.175] +synonym: "CPC acetylhydrolase activity" RELATED [EC:2.3.1.175] +synonym: "DAC acetyltransferase activity" RELATED [EC:2.3.1.175] +synonym: "DAC-AT" RELATED [EC:2.3.1.175] +synonym: "deacetylcephalosporin C acetyltransferase activity" RELATED [EC:2.3.1.175] +xref: EC:2.3.1.175 +xref: KEGG_REACTION:R03064 +xref: MetaCyc:2.3.1.175-RXN +xref: RHEA:23860 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0033814 +name: propanoyl-CoA C-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA." [EC:2.3.1.176] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity" RELATED [EC:2.3.1.176] +synonym: "peroxisomal thiolase 2 activity" NARROW [EC:2.3.1.176] +synonym: "PTE-2" RELATED [EC:2.3.1.176] +synonym: "SCP-X" RELATED [EC:2.3.1.176] +synonym: "SCPchi" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein-chi" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein-X" RELATED [EC:2.3.1.176] +xref: EC:2.3.1.176 +xref: MetaCyc:2.3.1.176-RXN +xref: RHEA:16865 +is_a: GO:0016408 ! C-acyltransferase activity + +[Term] +id: GO:0033815 +name: biphenyl synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2." [EC:2.3.1.177] +synonym: "BIS" RELATED [EC:2.3.1.177] +synonym: "malonyl-CoA:benzoyl-CoA malonyltransferase activity" RELATED [EC:2.3.1.177] +xref: EC:2.3.1.177 +xref: MetaCyc:2.3.1.177-RXN +xref: RHEA:22292 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033816 +name: diaminobutyrate acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+)." [EC:2.3.1.178, RHEA:16901] +synonym: "2,4-diaminobutanoate acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "DAB acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "DABA acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "DABAcT" RELATED [EC:2.3.1.178] +synonym: "diaminobutyric acid acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "EctA" RELATED [EC:2.3.1.178] +synonym: "L-2,4-diaminobutanoate acetyltransferase activity" RELATED [EC:2.3.1.178] +synonym: "L-2,4-diaminobutyrate acetyltransferase activity" RELATED [EC:2.3.1.178] +xref: EC:2.3.1.178 +xref: KEGG_REACTION:R06978 +xref: MetaCyc:R102-RXN +xref: RHEA:16901 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0033818 +name: beta-ketoacyl-acyl-carrier-protein synthase III activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.180] +synonym: "3-ketoacyl-acyl carrier protein synthase III activity" RELATED [EC:2.3.1.180] +synonym: "3-oxoacyl:ACP synthase III activity" RELATED [EC:2.3.1.180] +synonym: "acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity" RELATED [EC:2.3.1.180] +synonym: "beta-ketoacyl (acyl carrier protein) synthase III activity" RELATED [EC:2.3.1.180] +synonym: "beta-ketoacyl-ACP synthase III activity" RELATED [EC:2.3.1.180] +synonym: "beta-ketoacyl-acyl carrier protein synthase III activity" RELATED [EC:2.3.1.180] +synonym: "FabH" RELATED [EC:2.3.1.180] +synonym: "KAS III" RELATED [EC:2.3.1.180] +synonym: "KASIII" RELATED [EC:2.3.1.180] +xref: EC:2.3.1.180 +xref: MetaCyc:2.3.1.180-RXN +xref: RHEA:12080 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0033819 +name: lipoyl(octanoyl) transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein." [EC:2.3.1.181] +synonym: "LipB" RELATED [EC:2.3.1.181] +synonym: "lipoate/octanoate transferase activity" RELATED [EC:2.3.1.181] +synonym: "lipoyl (octanoyl)-acyl carrier protein:protein transferase activity" RELATED [EC:2.3.1.181] +synonym: "lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity" RELATED [EC:2.3.1.181] +synonym: "octanoyl-acyl carrier protein-protein N-octanoyltransferase activity" RELATED [EC:2.3.1.181] +synonym: "octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity" RELATED [EC:2.3.1.181] +synonym: "octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity" RELATED [EC:2.3.1.181] +xref: EC:2.3.1.181 +xref: MetaCyc:RXN0-947 +xref: Reactome:R-HSA-6793590 "LIPT2 transfers octanoyl group to GCSH" +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0033820 +name: DNA alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.26] +synonym: "T2-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26] +synonym: "T4-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26] +synonym: "T6-HMC-alpha-glucosyl transferase activity" RELATED [EC:2.4.1.26] +synonym: "UDP-glucose:DNA alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.26] +synonym: "UDPglucose-DNA alpha-glucosyltransferase activity" RELATED [EC:2.4.1.26] +synonym: "uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity" RELATED [EC:2.4.1.26] +xref: EC:2.4.1.26 +xref: MetaCyc:2.4.1.26-RXN +is_a: GO:0046527 ! glucosyltransferase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0033821 +name: DNA beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." [EC:2.4.1.27] +synonym: "T4 phage beta-glucosyltransferase activity" RELATED [EC:2.4.1.27] +synonym: "T4-beta-glucosyl transferase activity" RELATED [EC:2.4.1.27] +synonym: "T4-HMC-beta-glucosyl transferase activity" RELATED [EC:2.4.1.27] +synonym: "UDP glucose-DNA beta-glucosyltransferase activity" RELATED [EC:2.4.1.27] +synonym: "UDP-glucose:DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.27] +synonym: "UDPglucose:DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.27] +synonym: "uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity" RELATED [EC:2.4.1.27] +xref: EC:2.4.1.27 +xref: MetaCyc:2.4.1.27-RXN +is_a: GO:0046527 ! glucosyltransferase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0033822 +name: glucosyl-DNA beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA." [EC:2.4.1.28] +synonym: "T6-beta-glucosyl transferase activity" RELATED [EC:2.4.1.28] +synonym: "T6-glucosyl-HMC-beta-glucosyl transferase activity" RELATED [EC:2.4.1.28] +synonym: "UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.28] +synonym: "UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.28] +synonym: "uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity" RELATED [EC:2.4.1.28] +xref: EC:2.4.1.28 +xref: MetaCyc:2.4.1.28-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033823 +name: procollagen glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen." [EC:2.4.1.66] +synonym: "collagen glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "collagen hydroxylysyl glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "galactosylhydroxylysine glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "galactosylhydroxylysine-glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "galactosylhydroxylysyl glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "UDP-glucose-collagenglucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity" RELATED [EC:2.4.1.66] +synonym: "uridine diphosphoglucose-collagen glucosyltransferase activity" RELATED [EC:2.4.1.66] +xref: EC:2.4.1.66 +xref: MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-1981157 "Glucosylation of collagen propeptide hydroxylysines" +xref: RHEA:12576 +is_a: GO:0046527 ! glucosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0033824 +name: alternansucrase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages." [EC:2.4.1.140] +synonym: "sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity" RELATED [EC:2.4.1.140] +synonym: "sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.140] +synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity" BROAD [EC:2.4.1.140] +xref: EC:2.4.1.140 +xref: MetaCyc:2.4.1.140-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033825 +name: oligosaccharide 4-alpha-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides." [EC:2.4.1.161] +synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.161] +synonym: "1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity" RELATED [EC:2.4.1.161] +synonym: "amylase III activity" RELATED [EC:2.4.1.161] +xref: EC:2.4.1.161 +xref: MetaCyc:2.4.1.161-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033826 +name: xyloglucan 4-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage." [EC:2.4.1.168] +synonym: "UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168] +synonym: "UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168] +synonym: "uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity" RELATED [EC:2.4.1.168] +synonym: "xyloglucan 4beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.168] +synonym: "xyloglucan glucosyltransferase activity" RELATED [EC:2.4.1.168] +xref: EC:2.4.1.168 +xref: MetaCyc:2.4.1.168-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033827 +name: high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum." [EC:2.4.1.197] +synonym: "acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197] +synonym: "UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197] +synonym: "UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197] +synonym: "uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.197] +xref: EC:2.4.1.197 +xref: MetaCyc:2.4.1.197-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0033828 +name: glucosylglycerol-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+)." [EC:2.4.1.213, RHEA:12881] +synonym: "ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.213] +synonym: "ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.213] +synonym: "GG-phosphate synthase activity" RELATED [EC:2.4.1.213] +synonym: "GGPS" RELATED [EC:2.4.1.213] +synonym: "glucosyl-glycerol-phosphate synthase activity" RELATED [EC:2.4.1.213] +xref: EC:2.4.1.213 +xref: KEGG_REACTION:R05328 +xref: MetaCyc:2.4.1.213-RXN +xref: RHEA:12881 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033829 +name: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor." [EC:2.4.1.222] +synonym: "O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.222] +synonym: "UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.222] +xref: EC:2.4.1.222 +xref: MetaCyc:2.4.1.222-RXN +xref: Reactome:R-HSA-1912355 "Glycosylation of Pre-NOTCH by FRINGE" +xref: Reactome:R-HSA-5096538 "Defective LFNG does not transfer GlcNAc to Pre-NOTCH" +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0033830 +name: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." [EC:2.4.1.229] +synonym: "Skp1-HyPro GlcNAc-transferase activity" RELATED [EC:2.4.1.229] +synonym: "UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity" RELATED [EC:2.4.1.229] +synonym: "UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity" RELATED [EC:2.4.1.229] +synonym: "UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity" RELATED [EC:2.4.1.229] +synonym: "UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity" RELATED [EC:2.4.1.229] +xref: EC:2.4.1.229 +xref: RHEA:17841 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0033831 +name: kojibiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.230, RHEA:11176] +synonym: "2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.230] +xref: EC:2.4.1.230 +xref: KEGG_REACTION:R07264 +xref: MetaCyc:2.4.1.230-RXN +xref: RHEA:11176 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033832 +name: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.231] +synonym: "alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.231] +synonym: "trehalose phosphorylase activity" BROAD [EC:2.4.1.231] +xref: MetaCyc:RXN-4441 +xref: RHEA:16257 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033833 +name: hydroxymethylfurfural reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +xref: MetaCyc:RXN-10738 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033834 +name: kaempferol 3-O-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside." [EC:2.4.1.234] +synonym: "F3GalTase activity" RELATED [EC:2.4.1.234] +synonym: "UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.234] +xref: EC:2.4.1.234 +xref: MetaCyc:2.4.1.234-RXN +xref: RHEA:15709 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0033835 +name: flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]." [EC:2.4.1.236] +synonym: "1->2 UDP-rhamnosyltransferase activity" RELATED [EC:2.4.1.236] +synonym: "UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity" RELATED [EC:2.4.1.236] +synonym: "UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity" RELATED [EC:2.4.1.236] +xref: EC:2.4.1.236 +xref: MetaCyc:RXN-5001 +xref: MetaCyc:RXN-5002 +xref: MetaCyc:RXN-5004 +xref: MetaCyc:RXN-7759 +xref: MetaCyc:RXN-9699 +xref: RHEA:15473 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0033836 +name: flavonol 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside." [EC:2.4.1.237] +synonym: "UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.237] +synonym: "UDP-glucose:flavonol 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.237] +xref: EC:2.4.1.237 +xref: MetaCyc:2.4.1.237-RXN +xref: RHEA:23164 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033837 +name: anthocyanin 3'-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside." [EC:2.4.1.238] +synonym: "3'GT" RELATED [EC:2.4.1.238] +synonym: "UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.238] +synonym: "UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity" RELATED [EC:2.4.1.238] +xref: EC:2.4.1.238 +xref: MetaCyc:2.4.1.238-RXN +xref: RHEA:35627 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033838 +name: flavonol-3-O-glucoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.239] +synonym: "UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.239] +xref: EC:2.4.1.239 +xref: MetaCyc:2.4.1.239-RXN +xref: RHEA:18893 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033839 +name: flavonol-3-O-glycoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside." [EC:2.4.1.240] +synonym: "UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.240] +xref: EC:2.4.1.240 +xref: MetaCyc:2.4.1.240-RXN +xref: RHEA:23544 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033840 +name: NDP-glucose-starch glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1." [EC:2.4.1.242] +synonym: "GBSS" RELATED [EC:2.4.1.242] +synonym: "GBSSI" RELATED [EC:2.4.1.242] +synonym: "GBSSII" RELATED [EC:2.4.1.242] +synonym: "granule-bound starch synthase activity" RELATED [EC:2.4.1.242] +synonym: "granule-bound starch synthase I activity" RELATED [EC:2.4.1.242] +synonym: "granule-bound starch synthase II activity" RELATED [EC:2.4.1.242] +synonym: "NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.242] +synonym: "NDPglucose-starch glucosyltransferase activity" RELATED [EC:2.4.1.242] +synonym: "starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity" RELATED [EC:2.4.1.242] +synonym: "starch synthase II activity" RELATED [EC:2.4.1.242] +synonym: "waxy protein" RELATED [EC:2.4.1.242] +xref: EC:2.4.1.242 +xref: MetaCyc:2.4.1.242-RXN +xref: RHEA:15873 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0033841 +name: 6G-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0)." [EC:2.4.1.243] +synonym: "1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity" RELATED [EC:2.4.1.243] +synonym: "6G-FFT" RELATED [EC:2.4.1.243] +synonym: "6G-fructotransferase activity" RELATED [EC:2.4.1.243] +synonym: "6G-FT" RELATED [EC:2.4.1.243] +synonym: "fructan:fructan 6G-fructosyltransferase activity" RELATED [EC:2.4.1.243] +xref: EC:2.4.1.243 +xref: MetaCyc:2.4.1.243-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0033842 +name: N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group." [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase III activity" RELATED [EC:2.4.1.244] +synonym: "beta1,4-N-acetylgalactosaminyltransferase IV activity" RELATED [EC:2.4.1.244] +synonym: "beta4GalNAc-T3" RELATED [EC:2.4.1.244] +synonym: "beta4GalNAc-T4" RELATED [EC:2.4.1.244] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.244] +xref: EC:2.4.1.244 +xref: MetaCyc:2.4.1.244-RXN +xref: RHEA:20493 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0033843 +name: xyloglucan 6-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage." [EC:2.4.2.39] +synonym: "UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity" RELATED [EC:2.4.2.39] +synonym: "uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity" RELATED [EC:2.4.2.39] +synonym: "xyloglucan 6-alpha-D-xylosyltransferase activity" RELATED [EC:2.4.2.39] +xref: EC:2.4.2.39 +xref: MetaCyc:2.4.2.39-RXN +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0033844 +name: galactose-6-sulfurylase activity +namespace: molecular_function +def: "Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues." [EC:2.5.1.5] +synonym: "D-galactose-6-sulfate:alkyltransferase (cyclizing) activity" RELATED [EC:2.5.1.5] +synonym: "galactose 6-sulfatase activity" RELATED [EC:2.5.1.5] +synonym: "galactose-6-sulfatase activity" RELATED [EC:2.5.1.5] +synonym: "porphyran sulfatase activity" RELATED [EC:2.5.1.5] +xref: EC:2.5.1.5 +xref: MetaCyc:2.5.1.5-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033845 +name: hydroxymethylfurfural reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+." [GOC:jp, GOC:mah, PMID:15338422, PMID:16652391] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0033846 +name: adenosyl-fluoride synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine." [EC:2.5.1.63] +synonym: "fluorinase activity" RELATED [EC:2.5.1.63] +synonym: "S-adenosyl-L-methionine:fluoride adenosyltransferase activity" RELATED [EC:2.5.1.63] +xref: EC:2.5.1.63 +xref: MetaCyc:2.5.1.63-RXN +xref: RHEA:16661 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033847 +name: O-phosphoserine sulfhydrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate." [EC:2.5.1.65] +synonym: "O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.65] +synonym: "O-phosphoserine(thiol)-lyase activity" RELATED [EC:2.5.1.65] +xref: EC:2.5.1.65 +xref: MetaCyc:2.5.1.65-RXN +xref: RHEA:10252 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033848 +name: N2-(2-carboxyethyl)arginine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate." [EC:2.5.1.66, RHEA:10556] +synonym: "CEA synthetase activity" RELATED [EC:2.5.1.66] +synonym: "CEAS" RELATED [EC:2.5.1.66] +synonym: "glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" RELATED [EC:2.5.1.66] +synonym: "glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity" RELATED [EC:2.5.1.66] +synonym: "N2-(2-carboxyethyl)arginine synthetase activity" RELATED [EC:2.5.1.66] +xref: EC:2.5.1.66 +xref: KEGG_REACTION:R05465 +xref: MetaCyc:2.5.1.66-RXN +xref: RHEA:10556 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033849 +name: chrysanthemyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate." [EC:2.5.1.67, RHEA:14009] +synonym: "CPPase activity" RELATED [EC:2.5.1.67] +synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity" RELATED [EC:2.5.1.67] +xref: EC:2.5.1.67 +xref: KEGG_REACTION:R08948 +xref: MetaCyc:2.5.1.67-RXN +xref: RHEA:14009 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033850 +name: Z-farnesyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.68, RHEA:23300] +synonym: "(Z)-farnesyl diphosphate synthase activity" RELATED [EC:2.5.1.68] +synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity" RELATED [EC:2.5.1.68] +xref: EC:2.5.1.68 +xref: KEGG_REACTION:R08528 +xref: MetaCyc:2.5.1.68-RXN +xref: RHEA:23300 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033851 +name: lavandulyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate." [EC:2.5.1.69, RHEA:21676] +synonym: "dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity" RELATED [EC:2.5.1.69] +synonym: "FDS-5" RELATED [EC:2.5.1.69] +xref: EC:2.5.1.69 +xref: KEGG_REACTION:R08950 +xref: MetaCyc:2.5.1.69-RXN +xref: RHEA:21676 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0033852 +name: thyroid-hormone transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate." [EC:2.6.1.26, RHEA:19133] +synonym: "3,5-dinitrotyrosine aminotransferase activity" RELATED [EC:2.6.1.26] +synonym: "3,5-dinitrotyrosine transaminase activity" RELATED [EC:2.6.1.26] +synonym: "L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.26] +synonym: "thyroid hormone aminotransferase activity" RELATED [EC:2.6.1.26] +synonym: "thyroid-hormone aminotransferase activity" RELATED [EC:2.6.1.26] +xref: EC:2.6.1.26 +xref: KEGG_REACTION:R03952 +xref: MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN +xref: RHEA:19133 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033853 +name: aspartate-prephenate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate." [EC:2.6.1.78] +synonym: "L-arogenate:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.78] +synonym: "L-aspartate:prephenate aminotransferase activity" RELATED [EC:2.6.1.78] +synonym: "PAT" RELATED [EC:2.6.1.78] +synonym: "prephenate aspartate aminotransferase activity" RELATED [EC:2.6.1.78] +synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.78] +xref: EC:2.6.1.78 +xref: MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN +xref: RHEA:20445 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033854 +name: glutamate-prephenate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate." [EC:2.6.1.79, RHEA:22880] +synonym: "L-arogenate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.79] +synonym: "L-glutamate:prephenate aminotransferase activity" RELATED [EC:2.6.1.79] +synonym: "PAT" RELATED [EC:2.6.1.79] +synonym: "prephenate transaminase activity" BROAD [EC:2.6.1.79] +xref: EC:2.6.1.79 +xref: KEGG_REACTION:R07276 +xref: MetaCyc:PREPHENATE-TRANSAMINE-RXN +xref: RHEA:22880 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033855 +name: nicotianamine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate." [EC:2.6.1.80, RHEA:22104] +synonym: "NAAT" RELATED [EC:2.6.1.80] +synonym: "NAAT-I" RELATED [EC:2.6.1.80] +synonym: "NAAT-II" RELATED [EC:2.6.1.80] +synonym: "NAAT-III" RELATED [EC:2.6.1.80] +synonym: "nicotianamine transaminase activity" RELATED [EC:2.6.1.80] +synonym: "nicotianamine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.80] +xref: EC:2.6.1.80 +xref: KEGG_REACTION:R07277 +xref: MetaCyc:2.6.1.80-RXN +xref: RHEA:22104 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0033856 +name: pyridoxine 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate." [RHEA:15265] +synonym: "1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity" RELATED [EC:2.6.99.2] +synonym: "PNP synthase activity" RELATED [EC:2.6.99.2] +synonym: "pyridoxine 5-phosphate phospho lyase activity" RELATED [EC:2.6.99.2] +xref: EC:2.6.99.2 +xref: KEGG_REACTION:R05838 +xref: MetaCyc:PDXJ-RXN +xref: RHEA:15265 +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0033857 +name: diphosphoinositol-pentakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate." [EC:2.7.4.24] +synonym: "ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity" RELATED [EC:2.7.4.24] +synonym: "PP-InsP5 kinase activity" RELATED [EC:2.7.4.24] +synonym: "PP-IP5 kinase activity" RELATED [EC:2.7.4.24] +synonym: "PPIP5K" RELATED [EC:2.7.4.24] +synonym: "PPIP5K1" RELATED [EC:2.7.4.24] +synonym: "PPIP5K2" RELATED [EC:2.7.4.24] +synonym: "VIP1" NARROW [EC:2.7.4.24] +synonym: "VIP2" NARROW [EC:2.7.4.24] +xref: EC:2.7.4.24 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0033858 +name: N-acetylgalactosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate." [EC:2.7.1.157] +synonym: "ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity" RELATED [EC:2.7.1.157] +synonym: "GALK2" RELATED [EC:2.7.1.157] +synonym: "GalNAc kinase activity" RELATED [EC:2.7.1.157] +synonym: "GK2" RELATED [EC:2.7.1.157] +synonym: "N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity" RELATED [EC:2.7.1.157] +xref: EC:2.7.1.157 +xref: MetaCyc:2.7.1.157-RXN +xref: RHEA:12617 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033859 +name: furaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass." [GOC:jp, PMID:15338422, PMID:16652391] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0033860 +name: regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0033861 +name: negative regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +synonym: "down regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "down-regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "downregulation of NAD(P)H oxidase activity" EXACT [] +synonym: "inhibition of NAD(P)H oxidase activity" NARROW [] +is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity +is_a: GO:0051354 ! negative regulation of oxidoreductase activity + +[Term] +id: GO:0033862 +name: UMP kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + UMP = ADP + UDP." [EC:2.7.4.22] +synonym: "ATP:UMP phosphotransferase activity" RELATED [EC:2.7.4.22] +synonym: "PyrH" RELATED [EC:2.7.4.22] +synonym: "SmbA" RELATED [EC:2.7.4.22] +synonym: "UMP-kinase activity" RELATED [EC:2.7.4.22] +synonym: "UMPK" RELATED [EC:2.7.4.22] +synonym: "uridine monophosphate kinase activity" RELATED [EC:2.7.4.22] +xref: EC:2.7.4.22 +xref: MetaCyc:2.7.4.22-RXN +xref: RHEA:24400 +is_a: GO:0009041 ! uridylate kinase activity + +[Term] +id: GO:0033863 +name: ribose 1,5-bisphosphate phosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+)." [EC:2.7.4.23, RHEA:20109] +synonym: "ATP:ribose-1,5-bisphosphate phosphotransferase activity" RELATED [EC:2.7.4.23] +synonym: "PhnN" RELATED [EC:2.7.4.23] +synonym: "ribose 1,5-bisphosphokinase activity" RELATED [EC:2.7.4.23] +xref: EC:2.7.4.23 +xref: KEGG_REACTION:R06836 +xref: MetaCyc:2.7.4.23-RXN +xref: RHEA:20109 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0033864 +name: positive regulation of NAD(P)H oxidase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme NAD(P)H oxidase." [GOC:mah] +synonym: "activation of NAD(P)H oxidase activity" NARROW [] +synonym: "stimulation of NAD(P)H oxidase activity" NARROW [] +synonym: "up regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "up-regulation of NAD(P)H oxidase activity" EXACT [] +synonym: "upregulation of NAD(P)H oxidase activity" EXACT [] +is_a: GO:0033860 ! regulation of NAD(P)H oxidase activity +is_a: GO:0051353 ! positive regulation of oxidoreductase activity + +[Term] +id: GO:0033865 +name: nucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "nucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0006753 ! nucleoside phosphate metabolic process + +[Term] +id: GO:0033866 +name: nucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "nucleoside bisphosphate anabolism" EXACT [] +synonym: "nucleoside bisphosphate biosynthesis" EXACT [] +synonym: "nucleoside bisphosphate formation" EXACT [] +synonym: "nucleoside bisphosphatehate synthesis" EXACT [] +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process +is_a: GO:1901293 ! nucleoside phosphate biosynthetic process + +[Term] +id: GO:0033867 +name: Fas-activated serine/threonine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein." [EC:2.7.11.8] +synonym: "ATP:Fas-activated serine/threonine protein phosphotransferase activity" RELATED [EC:2.7.11.8] +synonym: "FAST" RELATED [EC:2.7.11.8] +synonym: "FASTK" RELATED [EC:2.7.11.8] +synonym: "STK10" RELATED [EC:2.7.11.8] +xref: EC:2.7.11.8 +xref: MetaCyc:2.7.11.8-RXN +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0033868 +name: obsolete Goodpasture-antigen-binding protein kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + Goodpasture antigen-binding protein = ADP + Goodpasture antigen-binding phosphoprotein." [EC:2.7.11.9] +comment: This term was made obsolete because it represents a specific gene product. +synonym: "ATP:Goodpasture antigen-binding protein phosphotransferase activity" RELATED [EC:2.7.11.9] +synonym: "Goodpasture antigen-binding protein kinase activity" RELATED [EC:2.7.11.9] +synonym: "GPBP kinase activity" RELATED [EC:2.7.11.9] +synonym: "GPBPK" RELATED [EC:2.7.11.9] +synonym: "STK11" RELATED [EC:2.7.11.9] +xref: EC:2.7.11.9 +xref: MetaCyc:2.7.11.9-RXN +is_obsolete: true + +[Term] +id: GO:0033869 +name: nucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside bisphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "nucleoside bisphosphate breakdown" EXACT [] +synonym: "nucleoside bisphosphate catabolism" EXACT [] +synonym: "nucleoside bisphosphate degradation" EXACT [] +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process +is_a: GO:1901292 ! nucleoside phosphate catabolic process + +[Term] +id: GO:0033870 +name: thiol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate." [EC:2.8.2.16] +synonym: "3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity" RELATED [EC:2.8.2.16] +synonym: "adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity" RELATED [EC:2.8.2.16] +synonym: "PAPS sulfotransferase activity" BROAD [EC:2.8.2.16] +xref: EC:2.8.2.16 +xref: MetaCyc:THIOL-SULFOTRANSFERASE-RXN +xref: RHEA:14637 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033871 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "3-OST-2" RELATED [EC:2.8.2.29] +synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29] +synonym: "glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" BROAD [EC:2.8.2.29] +synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED [] +synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] +xref: EC:2.8.2.29 +xref: MetaCyc:2.8.2.29-RXN +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0033872 +name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] +synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] +synonym: "3-OST-3" RELATED [EC:2.8.2.30] +synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30] +synonym: "glucosaminyl 3-O-sulfotransferase 3a, 3b activity" RELATED [EC:2.8.2.30] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30] +synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity" RELATED [EC:2.8.2.30] +synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED [] +synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] +xref: EC:2.8.2.30 +xref: MetaCyc:2.8.2.30-RXN +is_a: GO:0034483 ! heparan sulfate sulfotransferase activity + +[Term] +id: GO:0033873 +name: petromyzonol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.31, RHEA:16997] +synonym: "3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity" RELATED [EC:2.8.2.31] +synonym: "PZ-SULT" RELATED [EC:2.8.2.31] +xref: EC:2.8.2.31 +xref: KEGG_REACTION:R07797 +xref: MetaCyc:2.8.2.31-RXN +xref: RHEA:16997 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033874 +name: scymnol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.32, RHEA:15477] +xref: EC:2.8.2.32 +xref: KEGG_REACTION:R07798 +xref: MetaCyc:2.8.2.32-RXN +xref: RHEA:15477 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033875 +name: ribonucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "ribonucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process + +[Term] +id: GO:0033876 +name: glycochenodeoxycholate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+)." [EC:2.8.2.34, RHEA:17689] +synonym: "3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity" RELATED [EC:2.8.2.34] +synonym: "BAST" RELATED [EC:2.8.2.34] +synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" BROAD [EC:2.8.2.34] +synonym: "bile acid:PAPS:sulfotransferase activity" RELATED [EC:2.8.2.34] +xref: EC:2.8.2.34 +xref: KEGG_REACTION:R07289 +xref: MetaCyc:2.8.2.34-RXN +xref: RHEA:17689 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0033877 +name: succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity +namespace: molecular_function +alt_id: GO:0018728 +def: "Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate." [EC:2.8.3.15, RHEA:16469] +synonym: "benzylsuccinate CoA-transferase activity" RELATED [EC:2.8.3.15] +synonym: "succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity" RELATED [EC:2.8.3.15] +synonym: "succinyl-CoA:benzylsuccinate CoA-transferase activity" EXACT [] +xref: EC:2.8.3.15 +xref: KEGG_REACTION:R05588 +xref: MetaCyc:RXN-864 +xref: RHEA:16469 +xref: UM-BBD_reactionID:r0329 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0033878 +name: hormone-sensitive lipase activity +namespace: molecular_function +def: "Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate." [EC:3.1.1.79] +synonym: "diacylglycerol acylhydrolase activity" RELATED [EC:3.1.1.79] +synonym: "HSL" RELATED [EC:3.1.1.79] +xref: EC:3.1.1.79 +xref: MetaCyc:STEROL-ESTERASE-RXN +xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0033879 +name: acetylajmaline esterase activity +namespace: molecular_function +def: "Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate." [EC:3.1.1.80] +synonym: "17-O-acetylajmaline O-acetylhydrolase activity" RELATED [EC:3.1.1.80] +synonym: "2beta(R)-17-O-acetylajmalan:acetylesterase activity" RELATED [EC:3.1.1.80] +synonym: "AAE" RELATED [EC:3.1.1.80] +synonym: "acetylajmalan esterase activity" RELATED [EC:3.1.1.80] +xref: EC:3.1.1.80 +xref: MetaCyc:RXN-8652 +xref: MetaCyc:RXN-8653 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0033880 +name: phenylacetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate." [EC:3.1.2.25, RHEA:15337] +synonym: "phenylglyoxylyl-CoA hydrolase activity" RELATED [EC:3.1.2.25] +xref: EC:3.1.2.25 +xref: KEGG_REACTION:R07294 +xref: MetaCyc:3.1.2.25-RXN +xref: RHEA:15337 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033881 +name: bile-acid-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxycholoyl-CoA + H(2)O = CoA + deoxycholate + H(+)." [EC:3.1.2.26, RHEA:17693] +synonym: "bile acid-coenzyme A hydrolase activity" RELATED [EC:3.1.2.26] +synonym: "deoxycholoyl-CoA hydrolase activity" RELATED [EC:3.1.2.26] +xref: EC:3.1.2.26 +xref: KEGG_REACTION:R07295 +xref: MetaCyc:BACOAHYDRO-RXN +xref: RHEA:17693 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033882 +name: choloyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA." [EC:3.1.2.27] +synonym: "chenodeoxycholoyl-coenzyme A thioesterase activity" RELATED [EC:3.1.2.27] +synonym: "choloyl-coenzyme A thioesterase activity" RELATED [EC:3.1.2.27] +synonym: "peroxisomal acyl-CoA thioesterase 2 activity" NARROW [EC:3.1.2.27] +synonym: "PTE-2" RELATED [EC:3.1.2.27] +xref: EC:3.1.2.27 +xref: MetaCyc:3.1.2.27-RXN +xref: RHEA:14541 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0033883 +name: pyridoxal phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate." [EC:3.1.3.74] +synonym: "PLP phosphatase activity" RELATED [EC:3.1.3.74] +synonym: "PNP phosphatase activity" RELATED [EC:3.1.3.74] +synonym: "pyridoxal-5'-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.74] +synonym: "vitamin B6 (pyridoxine) phosphatase activity" BROAD [EC:3.1.3.74] +synonym: "vitamin B6-phosphate phosphatase activity" BROAD [EC:3.1.3.74] +xref: EC:3.1.3.74 +xref: MetaCyc:3.1.3.74-RXN +xref: RHEA:20533 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0033884 +name: obsolete phosphoethanolamine/phosphocholine phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: O-phosphoethanolamine + H2O = ethanolamine + phosphate, and phosphocholine + H2O = choline + phosphate." [EC:3.1.3.75] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "3X11A" RELATED [EC:3.1.3.75] +synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] +synonym: "phosphoethanolamine phosphohydrolase activity" NARROW [EC:3.1.3.75] +synonym: "phosphoethanolamine/phosphocholine phosphatase activity" EXACT [] +is_obsolete: true +consider: GO:0052731 +consider: GO:0052732 + +[Term] +id: GO:0033885 +name: 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate." [EC:3.1.3.76, RHEA:16537] +synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity" RELATED [EC:3.1.3.76] +synonym: "(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.76] +synonym: "dihydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76] +synonym: "hydroxy fatty acid phosphatase activity" BROAD [EC:3.1.3.76] +synonym: "hydroxy lipid phosphatase activity" BROAD [EC:3.1.3.76] +synonym: "lipid-phosphate phosphatase activity" BROAD [EC:3.1.3.76] +synonym: "sEH" RELATED [EC:3.1.3.76] +synonym: "soluble epoxide hydrolase activity" RELATED [EC:3.1.3.76] +xref: EC:3.1.3.76 +xref: KEGG_REACTION:R07582 +xref: MetaCyc:3.1.3.76-RXN +xref: RHEA:16537 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0033886 +name: cellulose-polysulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin." [EC:3.1.6.7] +synonym: "cellulose-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.7] +xref: EC:3.1.6.7 +xref: MetaCyc:3.1.6.7-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033887 +name: chondro-4-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.9, RHEA:11444] +synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" RELATED [EC:3.1.6.9] +xref: EC:3.1.6.9 +xref: KEGG_REACTION:R03517 +xref: MetaCyc:CHONDRO-4-SULFATASE-RXN +xref: RHEA:11444 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033888 +name: chondro-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate." [EC:3.1.6.10, RHEA:10536] +synonym: "4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" RELATED [EC:3.1.6.10] +xref: EC:3.1.6.10 +xref: KEGG_REACTION:R03518 +xref: MetaCyc:CHONDRO-6-SULFATASE-RXN +xref: RHEA:10536 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033889 +name: N-sulfoglucosamine-3-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin." [EC:3.1.6.15] +synonym: "chondroitinsulfatase activity" BROAD [EC:3.1.6.15] +synonym: "N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity" RELATED [EC:3.1.6.15] +xref: EC:3.1.6.15 +xref: MetaCyc:3.1.6.15-RXN +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0033890 +name: ribonuclease D activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides." [EC:3.1.13.5] +synonym: "RNase D activity" RELATED [EC:3.1.13.5] +xref: EC:3.1.13.5 +xref: MetaCyc:3.1.13.5-RXN +is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033891 +name: CC-preferring endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC." [EC:3.1.21.6] +synonym: "5'-CC-3'-preferring endodeoxyribonuclease activity" RELATED [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity" RELATED [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity" RELATED [EC:3.1.21.6] +synonym: "Streptomyces glaucescens exocytoplasmic endonuclease activity" RELATED [EC:3.1.21.6] +xref: EC:3.1.21.6 +xref: MetaCyc:3.1.21.6-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033892 +name: deoxyribonuclease (pyrimidine dimer) activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] +synonym: "bacteriophage T4 endodeoxyribonuclease V activity" RELATED [EC:3.1.25.1] +synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" RELATED [EC:3.1.25.1] +synonym: "T4 endonuclease V activity" RELATED [EC:3.1.25.1] +xref: EC:3.1.25.1 +xref: MetaCyc:3.1.25.1-RXN +is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base + +[Term] +id: GO:0033893 +name: ribonuclease IV activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.6] +synonym: "endoribonuclease IV activity" RELATED [EC:3.1.26.6] +xref: EC:3.1.26.6 +xref: MetaCyc:3.1.26.6-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033894 +name: ribonuclease P4 activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor." [EC:3.1.26.7] +xref: EC:3.1.26.7 +xref: MetaCyc:3.1.26.7-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033895 +name: ribonuclease [poly-(U)-specific] activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.9] +synonym: "ribonuclease (uracil-specific) activity" RELATED [EC:3.1.26.9] +synonym: "uracil-specific endoribonuclease activity" RELATED [EC:3.1.26.9] +synonym: "uracil-specific RNase activity" RELATED [EC:3.1.26.9] +xref: EC:3.1.26.9 +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033896 +name: ribonuclease IX activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups." [EC:3.1.26.10] +synonym: "poly(U)- and poly(C)-specific endoribonuclease activity" RELATED [EC:3.1.26.10] +xref: EC:3.1.26.10 +xref: MetaCyc:3.1.26.10-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0033897 +name: ribonuclease T2 activity +namespace: molecular_function +def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.19] +synonym: "acid ribonuclease activity" EXACT [] +synonym: "acid RNase activity" EXACT [] +synonym: "base-non-specific ribonuclease activity" EXACT [] +synonym: "Escherichia coli ribonuclease I' ribonuclease PP2 activity" EXACT [] +synonym: "Escherichia coli ribonuclease II activity" RELATED [EC:4.6.1.19] +synonym: "non-base specific ribonuclease activity" EXACT [] +synonym: "nonbase-specific RNase activity" EXACT [] +synonym: "nonspecific RNase activity" EXACT [] +synonym: "ribonnuclease (non-base specific) activity" EXACT [] +synonym: "ribonuclease (non-base specific) activity" RELATED [] +synonym: "ribonuclease II activity" BROAD [EC:4.6.1.19] +synonym: "ribonuclease M activity" EXACT [] +synonym: "ribonuclease N2 activity" EXACT [] +synonym: "ribonuclease PP3 activity" RELATED [] +synonym: "ribonuclease U4 activity" EXACT [] +synonym: "ribonucleate 3'-oligonucleotide hydrolase activity" EXACT [] +synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [] +synonym: "RNAase CL activity" EXACT [] +synonym: "RNase (non-base specific) activity" EXACT [] +synonym: "RNase II activity" BROAD [EC:4.6.1.19] +synonym: "RNase M activity" RELATED [] +synonym: "RNase Ms activity" EXACT [] +synonym: "RNase T2 activity" RELATED [EC:4.6.1.19] +xref: EC:4.6.1.19 +xref: MetaCyc:3.1.27.1-RXN +is_a: GO:0004521 ! endoribonuclease activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0033898 +name: Bacillus subtilis ribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides." [EC:4.6.1.22] +synonym: "proteus mirabilis RNase activity" EXACT [] +synonym: "ribonucleate nucleotido-2'-transferase (cyclizing) activity" BROAD [] +xref: EC:4.6.1.22 +xref: MetaCyc:3.1.27.2-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033899 +name: ribonuclease U2 activity +namespace: molecular_function +def: "Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates." [EC:4.6.1.20] +synonym: "pleospora RNase activity" EXACT [] +synonym: "purine specific endoribonuclease activity" EXACT [] +synonym: "purine-specific ribonuclease activity" EXACT [] +synonym: "purine-specific RNase activity" EXACT [] +synonym: "ribonuclease (purine) activity" EXACT [] +synonym: "RNase U2 activity" RELATED [EC:4.6.1.20] +synonym: "trichoderma koningi RNase III activity" EXACT [] +xref: EC:4.6.1.20 +xref: MetaCyc:3.1.27.4-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033900 +name: ribonuclease F activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups." [EC:3.1.27.7] +synonym: "ribonuclease F (E. coli) activity" RELATED [EC:3.1.27.7] +synonym: "RNase F activity" RELATED [EC:3.1.27.7] +xref: EC:3.1.27.7 +xref: MetaCyc:3.1.27.7-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033901 +name: ribonuclease V activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP." [EC:3.1.27.8] +synonym: "endoribonuclease V activity" RELATED [EC:3.1.27.8] +xref: EC:3.1.27.8 +xref: MetaCyc:3.1.27.8-RXN +is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters + +[Term] +id: GO:0033902 +name: rRNA endonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes." [GOC:curators] +synonym: "alpha-sarcin" RELATED [] +xref: EC:4.6.1.23 +xref: MetaCyc:3.1.27.10-RXN +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0033903 +name: obsolete endo-1,3(4)-beta-glucanase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] +comment: This term was made obsolete because it was representing two different activities, for which new GO terms have now been created: GO:0052861 glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group and GO:0052862 glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group. +synonym: "1,3-(1,3;1,4)-beta-D-glucan 3(4)-glucanohydrolase activity" RELATED [EC:3.2.1.6] +synonym: "beta-1,3-1,4-glucanase activity" RELATED [EC:3.2.1.6] +synonym: "beta-1,3-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,3(4)-beta-glucanase activity" EXACT [] +synonym: "endo-1,3-1,4-beta-D-glucanase activity" RELATED [EC:3.2.1.6] +synonym: "endo-1,3-beta-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,3-beta-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-(1,3)-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-(1->3)-D-glucanase activity" BROAD [EC:3.2.1.6] +synonym: "endo-beta-1,3(4)-glucanase activity" RELATED [EC:3.2.1.6] +synonym: "endo-beta-1,3-1,4-glucanase activity" RELATED [EC:3.2.1.6] +synonym: "endo-beta-1,3-glucanase IV activity" RELATED [EC:3.2.1.6] +synonym: "laminaranase activity" BROAD [EC:3.2.1.6] +synonym: "laminarinase activity" BROAD [EC:3.2.1.6] +xref: EC:3.2.1.6 +xref: MetaCyc:3.2.1.6-RXN +is_obsolete: true +consider: GO:0052861 +consider: GO:0052862 + +[Term] +id: GO:0033904 +name: dextranase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran." [EC:3.2.1.11] +synonym: "1,6-alpha-D-glucan 6-glucanohydrolase activity" RELATED [EC:3.2.1.11] +synonym: "alpha-1,6-glucan-6-glucanohydrolase activity" RELATED [EC:3.2.1.11] +synonym: "alpha-D-1,6-glucan-6-glucanohydrolase activity" RELATED [EC:3.2.1.11] +synonym: "dextran hydrolase activity" RELATED [EC:3.2.1.11] +synonym: "dextranase DL 2 activity" NARROW [EC:3.2.1.11] +synonym: "DL 2" RELATED [EC:3.2.1.11] +synonym: "endo-dextranase activity" RELATED [EC:3.2.1.11] +synonym: "endodextranase activity" RELATED [EC:3.2.1.11] +xref: EC:3.2.1.11 +xref: MetaCyc:3.2.1.11-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033905 +name: xylan endo-1,3-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans." [EC:3.2.1.32] +synonym: "1,3-beta-D-xylan xylanohydrolase activity" RELATED [EC:3.2.1.32] +synonym: "1,3-beta-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "1,3-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "beta-1,3-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "endo-1,3-beta-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "endo-1,3-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "endo-beta-1,3-xylanase activity" RELATED [EC:3.2.1.32] +synonym: "xylanase activity" BROAD [EC:3.2.1.32] +xref: EC:3.2.1.32 +xref: MetaCyc:3.2.1.32-RXN +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0033906 +name: hyaluronoglucuronidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate." [EC:3.2.1.36] +synonym: "glucuronoglucosaminoglycan hyaluronate lyase activity" RELATED [EC:3.2.1.36] +synonym: "hyaluronate 3-glycanohydrolase activity" RELATED [EC:3.2.1.36] +synonym: "hyaluronidase activity" BROAD [EC:3.2.1.36] +synonym: "orgelase activity" RELATED [EC:3.2.1.36] +xref: EC:3.2.1.36 +xref: MetaCyc:3.2.1.36-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033907 +name: beta-D-fucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides." [EC:3.2.1.38] +synonym: "beta-D-fucoside fucohydrolase activity" RELATED [EC:3.2.1.38] +synonym: "beta-fucosidase activity" RELATED [EC:3.2.1.38] +xref: EC:3.2.1.38 +xref: MetaCyc:3.2.1.38-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033908 +name: beta-L-rhamnosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides." [EC:3.2.1.43] +synonym: "beta-L-rhamnoside rhamnohydrolase activity" RELATED [EC:3.2.1.43] +xref: EC:3.2.1.43 +xref: MetaCyc:3.2.1.43-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033909 +name: fucoidanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate." [PMID:11910806, PMID:6417453] +synonym: "poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity" RELATED [EC:3.2.1.211] +xref: EC:3.2.1.211 +xref: MetaCyc:RXN-20949 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033910 +name: glucan 1,4-alpha-maltotetraohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends." [EC:3.2.1.60] +synonym: "1,4-alpha-D-glucan maltotetraohydrolase activity" RELATED [EC:3.2.1.60] +synonym: "exo-maltotetraohydrolase activity" RELATED [EC:3.2.1.60] +synonym: "G4-amylase activity" RELATED [EC:3.2.1.60] +synonym: "glucan 1,4-alpha-maltotetrahydrolase activity" RELATED [EC:3.2.1.60] +synonym: "maltotetraose-forming amylase activity" RELATED [EC:3.2.1.60] +xref: EC:3.2.1.60 +xref: MetaCyc:3.2.1.60-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033911 +name: mycodextranase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds." [EC:3.2.1.61] +synonym: "1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.61] +xref: EC:3.2.1.61 +xref: MetaCyc:3.2.1.61-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033912 +name: 2,6-beta-fructan 6-levanbiohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." [EC:3.2.1.64] +synonym: "2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity" RELATED [EC:3.2.1.64] +synonym: "2,6-beta-D-fructan 6-levanbiohydrolase activity" RELATED [EC:3.2.1.64] +synonym: "2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity" RELATED [EC:3.2.1.64] +synonym: "beta-2,6-fructan-6-levanbiohydrolase activity" RELATED [EC:3.2.1.64] +synonym: "levanbiose-producing levanase activity" RELATED [EC:3.2.1.64] +xref: EC:3.2.1.64 +xref: MetaCyc:3.2.1.64-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033913 +name: glucan endo-1,2-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans." [EC:3.2.1.71] +synonym: "1,2-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.71] +synonym: "beta-D-1,2-glucanase activity" RELATED [EC:3.2.1.71] +synonym: "endo-(1->2)-beta-D-glucanase activity" RELATED [EC:3.2.1.71] +synonym: "endo-1,2-beta-glucanase activity" RELATED [EC:3.2.1.71] +xref: EC:3.2.1.71 +xref: MetaCyc:3.2.1.71-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0033914 +name: xylan 1,3-beta-xylosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans." [EC:3.2.1.72] +synonym: "1,3-beta-D-xylan xylohydrolase activity" RELATED [EC:3.2.1.72] +synonym: "1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity" RELATED [EC:3.2.1.72] +synonym: "beta-1,3'-xylanase activity" RELATED [EC:3.2.1.72] +synonym: "exo-1,3-beta-xylosidase activity" RELATED [EC:3.2.1.72] +synonym: "exo-beta-1,3'-xylanase activity" RELATED [EC:3.2.1.72] +xref: EC:3.2.1.72 +xref: MetaCyc:3.2.1.72-RXN +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0033915 +name: mannan 1,2-(1,3)-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose." [EC:3.2.1.77] +synonym: "1,2-1,3-alpha-D-mannan mannohydrolase activity" RELATED [EC:3.2.1.77] +synonym: "exo-1,2-1,3-alpha-mannosidase activity" RELATED [EC:3.2.1.77] +xref: EC:3.2.1.77 +xref: MetaCyc:3.2.1.77-RXN +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0033916 +name: beta-agarase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product." [EC:3.2.1.81] +synonym: "AgaA" RELATED [EC:3.2.1.81] +synonym: "AgaB" RELATED [EC:3.2.1.81] +synonym: "agarase activity" BROAD [EC:3.2.1.81] +synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.81] +synonym: "agarose 4-glycanohydrolase activity" RELATED [EC:3.2.1.81] +xref: EC:3.2.1.81 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033917 +name: exo-poly-alpha-galacturonosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate." [EC:3.2.1.82] +synonym: "exopolygalacturanosidase activity" RELATED [EC:3.2.1.82] +synonym: "exopolygalacturonosidase activity" RELATED [EC:3.2.1.82] +xref: EC:3.2.1.82 +xref: MetaCyc:3.2.1.82-RXN +xref: RHEA:56232 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033918 +name: kappa-carrageenase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans." [EC:3.2.1.83] +synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity" RELATED [EC:3.2.1.83] +synonym: "kappa-carrageenan 4-beta-D-glycanohydrolase activity" RELATED [EC:3.2.1.83] +xref: EC:3.2.1.83 +xref: MetaCyc:3.2.1.83-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033919 +name: glucan 1,3-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans." [EC:3.2.1.84] +synonym: "1,3-alpha-D-glucan 3-glucohydrolase activity" RELATED [EC:3.2.1.84] +synonym: "exo-1,3-alpha-glucanase activity" RELATED [EC:3.2.1.84] +xref: EC:3.2.1.84 +xref: MetaCyc:3.2.1.84-RXN +xref: Reactome:R-HSA-532667 "Removal of the second glucose by glucosidase II" +xref: Reactome:R-HSA-548890 "Removal of the third glucose by glucosidase II and release from the chaperone" +xref: Reactome:R-HSA-9683663 "N-glycan trimming of Spike" +xref: Reactome:R-HSA-9694364 "N-glycan glucose trimming of Spike" +is_a: GO:0090600 ! alpha-1,3-glucosidase activity + +[Term] +id: GO:0033920 +name: 6-phospho-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol." [EC:3.2.1.85] +synonym: "6-phospho-beta-D-galactosidase activity" RELATED [EC:3.2.1.85] +synonym: "6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity" RELATED [EC:3.2.1.85] +synonym: "beta-D-phosphogalactoside galactohydrolase activity" RELATED [EC:3.2.1.85] +synonym: "phospho-beta-D-galactosidase activity" RELATED [EC:3.2.1.85] +synonym: "phospho-beta-galactosidase activity" RELATED [EC:3.2.1.85] +xref: EC:3.2.1.85 +xref: MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN +xref: RHEA:24568 +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0033921 +name: capsular-polysaccharide endo-1,3-alpha-galactosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide." [EC:3.2.1.87] +synonym: "aerobacter-capsular-polysaccharide galactohydrolase activity" RELATED [EC:3.2.1.87] +synonym: "capsular polysaccharide galactohydrolase activity" RELATED [EC:3.2.1.87] +synonym: "polysaccharide depolymerase activity" RELATED [EC:3.2.1.87] +xref: EC:3.2.1.87 +xref: MetaCyc:3.2.1.87-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0033922 +name: peptidoglycan beta-N-acetylmuramidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues." [EC:3.2.1.92] +synonym: "beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity" RELATED [EC:3.2.1.92] +synonym: "exo-beta-acetylmuramidase activity" RELATED [EC:3.2.1.92] +synonym: "exo-beta-N-acetylmuramidase activity" RELATED [EC:3.2.1.92] +synonym: "peptidoglycan beta-N-acetylmuramoylexohydrolase activity" RELATED [EC:3.2.1.92] +xref: EC:3.2.1.92 +xref: MetaCyc:3.2.1.92-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033923 +name: glucan 1,6-alpha-isomaltosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains." [EC:3.2.1.94] +synonym: "1,6-alpha-D-glucan isomaltohydrolase activity" RELATED [EC:3.2.1.94] +synonym: "exo-isomaltohydrolase activity" RELATED [EC:3.2.1.94] +synonym: "G2-dextranase activity" RELATED [EC:3.2.1.94] +synonym: "isomalto-dextranase activity" RELATED [EC:3.2.1.94] +synonym: "isomaltodextranase activity" RELATED [EC:3.2.1.94] +xref: EC:3.2.1.94 +xref: MetaCyc:3.2.1.94-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033924 +name: dextran 1,6-alpha-isomaltotriosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains." [EC:3.2.1.95] +synonym: "1,6-alpha-D-glucan isomaltotriohydrolase activity" RELATED [EC:3.2.1.95] +synonym: "exo-isomaltotriohydrolase activity" RELATED [EC:3.2.1.95] +xref: EC:3.2.1.95 +xref: MetaCyc:3.2.1.95-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033925 +name: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact." [EC:3.2.1.96] +synonym: "di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-(1->4)-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-acetylglucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase D activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase F activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase H activity" RELATED [EC:3.2.1.96] +synonym: "endo-beta-N-acetylglucosaminidase L activity" RELATED [EC:3.2.1.96] +synonym: "endo-N-acetyl-beta-D-glucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endo-N-acetyl-beta-glucosaminidase activity" RELATED [EC:3.2.1.96] +synonym: "endoglycosidase H activity" RELATED [EC:3.2.1.96] +synonym: "endoglycosidase S activity" RELATED [EC:3.2.1.96] +synonym: "glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED [EC:3.2.1.96] +synonym: "glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity" RELATED [EC:3.2.1.96] +synonym: "mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity" RELATED [EC:3.2.1.96] +synonym: "mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity" RELATED [EC:3.2.1.96] +synonym: "N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity" RELATED [EC:3.2.1.96] +xref: EC:3.2.1.96 +xref: MetaCyc:3.2.1.96-RXN +xref: Reactome:R-HSA-8853379 "ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033926 +name: glycopeptide alpha-N-acetylgalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins." [EC:3.2.1.97, MetaCyc:3.2.1.97-RXN] +synonym: "D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity" RELATED [EC:3.2.1.97] +synonym: "endo-alpha-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] +synonym: "endo-alpha-N-acetylgalactosaminidase activity" BROAD [EC:3.2.1.97] +xref: EC:3.2.1.97 +xref: MetaCyc:3.2.1.97-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0033927 +name: glucan 1,4-alpha-maltohexaosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends." [EC:3.2.1.98] +synonym: "1,4-alpha-D-glucan maltohexaohydrolase activity" RELATED [EC:3.2.1.98] +synonym: "exo-maltohexaohydrolase activity" RELATED [EC:3.2.1.98] +synonym: "G6-amylase activity" RELATED [EC:3.2.1.98] +synonym: "maltohexaose-producing amylase activity" RELATED [EC:3.2.1.98] +xref: EC:3.2.1.98 +xref: MetaCyc:3.2.1.98-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033928 +name: mannan 1,4-mannobiosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends." [EC:3.2.1.100] +synonym: "1,4-beta-D-mannan mannobiohydrolase activity" BROAD [EC:3.2.1.100] +synonym: "exo-1,4-beta-mannobiohydrolase activity" RELATED [EC:3.2.1.100] +synonym: "exo-beta-mannanase activity" RELATED [EC:3.2.1.100] +synonym: "mannan 1,4-beta-mannobiosidase activity" RELATED [EC:3.2.1.100] +xref: EC:3.2.1.100 +xref: MetaCyc:3.2.1.100-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033929 +name: blood-group-substance endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances." [EC:3.2.1.102] +synonym: "blood-group-substance 1,4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.102] +synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.102] +xref: EC:3.2.1.102 +xref: MetaCyc:3.2.1.102-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0033930 +name: keratan-sulfate endo-1,4-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate." [EC:3.2.1.103] +synonym: "endo-beta-galactosidase activity" BROAD [EC:3.2.1.103] +synonym: "keratan sulfate endogalactosidase activity" RELATED [EC:3.2.1.103] +synonym: "keratan-sulfate 1,4-beta-D-galactanohydrolase activity" RELATED [EC:3.2.1.103] +synonym: "keratanase activity" RELATED [EC:3.2.1.103] +xref: EC:3.2.1.103 +xref: MetaCyc:3.2.1.103-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0033931 +name: endogalactosaminidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine)." [EC:3.2.1.109] +synonym: "galactosaminoglycan glycanohydrolase activity" RELATED [EC:3.2.1.109] +xref: EC:3.2.1.109 +xref: MetaCyc:3.2.1.109-RXN +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0033932 +name: 1,3-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins." [EC:3.2.1.111] +synonym: "3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity" RELATED [EC:3.2.1.111] +synonym: "almond emulsin fucosidase I activity" RELATED [EC:3.2.1.111] +xref: EC:3.2.1.111 +xref: MetaCyc:3.2.1.111-RXN +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0033933 +name: branched-dextran exo-1,2-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose." [EC:3.2.1.115] +synonym: "1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity" RELATED [EC:3.2.1.115] +synonym: "dextran 1,2-alpha-glucosidase activity" RELATED [EC:3.2.1.115] +synonym: "dextran alpha-1,2 debranching enzyme" RELATED [EC:3.2.1.115] +xref: EC:3.2.1.115 +xref: MetaCyc:3.2.1.115-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0033934 +name: glucan 1,4-alpha-maltotriohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends." [EC:3.2.1.116] +synonym: "1,4-alpha-D-glucan maltotriohydrolase activity" RELATED [EC:3.2.1.116] +synonym: "exo-maltotriohydrolase activity" RELATED [EC:3.2.1.116] +synonym: "maltotriohydrolase activity" RELATED [EC:3.2.1.116] +xref: EC:3.2.1.116 +xref: MetaCyc:3.2.1.116-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033935 +name: oligoxyloglucan beta-glycosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends." [EC:3.2.1.120] +synonym: "isoprimeverose-producing oligoxyloglucan hydrolase activity" RELATED [EC:3.2.1.120] +synonym: "oligoxyloglucan hydrolase activity" RELATED [EC:3.2.1.120] +synonym: "oligoxyloglucan xyloglucohydrolase activity" RELATED [EC:3.2.1.120] +xref: EC:3.2.1.120 +xref: MetaCyc:3.2.1.120-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0033936 +name: polymannuronate hydrolase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate." [EC:3.2.1.121] +synonym: "poly(mannuronide) mannuronohydrolase activity" RELATED [EC:3.2.1.121] +synonym: "polymannuronic acid polymerase activity" RELATED [EC:3.2.1.121] +xref: EC:3.2.1.121 +xref: MetaCyc:3.2.1.121-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033937 +name: 3-deoxy-2-octulosonidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides." [EC:3.2.1.124] +synonym: "2-keto-3-deoxyoctonate hydrolase activity" RELATED [EC:3.2.1.124] +synonym: "capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity" RELATED [EC:3.2.1.124] +synonym: "octulofuranosylono hydrolase activity" RELATED [EC:3.2.1.124] +synonym: "octulopyranosylonohydrolase activity" RELATED [EC:3.2.1.124] +synonym: "octulosylono hydrolase activity" RELATED [EC:3.2.1.124] +xref: EC:3.2.1.124 +xref: MetaCyc:3.2.1.124-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033938 +name: 1,6-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin." [EC:3.2.1.127] +synonym: "1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity" RELATED [EC:3.2.1.127] +xref: EC:3.2.1.127 +xref: MetaCyc:3.2.1.127-RXN +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0033939 +name: xylan alpha-1,2-glucuronosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans." [EC:3.2.1.131] +synonym: "1,2-alpha-glucuronidase activity" RELATED [EC:3.2.1.131] +synonym: "alpha-(1->2)-glucuronidase activity" RELATED [EC:3.2.1.131] +synonym: "xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity" RELATED [EC:3.2.1.131] +xref: EC:3.2.1.131 +xref: MetaCyc:3.2.1.131-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033940 +name: glucuronoarabinoxylan endo-1,4-beta-xylanase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans." [EC:3.2.1.136] +synonym: "endoarabinoxylanase activity" RELATED [EC:3.2.1.136] +synonym: "feraxan endoxylanase activity" RELATED [EC:3.2.1.136] +synonym: "feraxanase activity" RELATED [EC:3.2.1.136] +synonym: "glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity" RELATED [EC:3.2.1.136] +synonym: "glucuronoxylan xylanohydrolase activity" RELATED [EC:3.2.1.136] +synonym: "glucuronoxylan xylohydrolase activity" RELATED [EC:3.2.1.136] +synonym: "glucuronoxylanase activity" RELATED [EC:3.2.1.136] +xref: EC:3.2.1.136 +xref: MetaCyc:3.2.1.136-RXN +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0033941 +name: mannan exo-1,2-1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose." [EC:3.2.1.137] +synonym: "1,2-1,6-alpha-D-mannan D-mannohydrolase activity" RELATED [EC:3.2.1.137] +synonym: "exo-1,2-1,6-alpha-mannosidase activity" RELATED [EC:3.2.1.137] +xref: EC:3.2.1.137 +xref: MetaCyc:3.2.1.137-RXN +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0033942 +name: 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan." [EC:3.2.1.141] +synonym: "4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" RELATED [EC:3.2.1.141] +synonym: "4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity" RELATED [EC:3.2.1.141] +synonym: "malto-oligosyltrehalose trehalohydrolase activity" RELATED [EC:3.2.1.141] +synonym: "maltooligosyl trehalose trehalohydrolase activity" RELATED [EC:3.2.1.141] +xref: EC:3.2.1.141 +xref: MetaCyc:3.2.1.141-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033943 +name: galactan 1,3-beta-galactosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans." [EC:3.2.1.145] +synonym: "galactan (1,3)-beta-D-galactosidase activity" RELATED [EC:3.2.1.145] +synonym: "galactan (1->3)-beta-D-galactosidase activity" RELATED [EC:3.2.1.145] +xref: EC:3.2.1.145 +xref: MetaCyc:3.2.1.145-RXN +is_a: GO:0015925 ! galactosidase activity + +[Term] +id: GO:0033944 +name: beta-galactofuranosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose." [EC:3.2.1.146] +synonym: "beta-D-galactofuranosidase activity" RELATED [EC:3.2.1.146] +synonym: "beta-D-galactofuranoside hydrolase activity" RELATED [EC:3.2.1.146] +synonym: "exo-beta-D-galactofuranosidase activity" RELATED [EC:3.2.1.146] +synonym: "exo-beta-galactofuranosidase activity" RELATED [EC:3.2.1.146] +xref: EC:3.2.1.146 +xref: MetaCyc:3.2.1.146-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033945 +name: oligoxyloglucan reducing-end-specific cellobiohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted." [EC:3.2.1.150] +synonym: "oligoxyloglucan reducing end-specific cellobiohydrolase activity" RELATED [EC:3.2.1.150] +synonym: "oligoxyloglucan reducing-end cellobiohydrolase activity" RELATED [EC:3.2.1.150] +xref: EC:3.2.1.150 +xref: MetaCyc:3.2.1.150-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033946 +name: xyloglucan-specific endo-beta-1,4-glucanase activity +namespace: molecular_function +def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.151] +synonym: "1,4-beta-D-glucan glucanohydrolase activity" BROAD [EC:3.2.1.151] +synonym: "[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.151] +synonym: "XEG" RELATED [EC:3.2.1.151] +synonym: "XH" RELATED [EC:3.2.1.151] +synonym: "xyloglucan endo-beta-1,4-glucanase activity" RELATED [EC:3.2.1.151] +synonym: "xyloglucanase activity" RELATED [EC:3.2.1.151] +synonym: "xyloglucanendohydrolase activity" RELATED [EC:3.2.1.151] +xref: EC:3.2.1.151 +xref: MetaCyc:3.2.1.151-RXN +is_a: GO:0052736 ! beta-glucanase activity + +[Term] +id: GO:0033947 +name: mannosylglycoprotein endo-beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences." [EC:3.2.1.152] +synonym: "endo-beta-mannosidase activity" RELATED [EC:3.2.1.152] +xref: EC:3.2.1.152 +xref: MetaCyc:3.2.1.152-RXN +is_a: GO:0004567 ! beta-mannosidase activity + +[Term] +id: GO:0033948 +name: fructan beta-(2,1)-fructosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.153] +synonym: "1-FEH II" RELATED [EC:3.2.1.153] +synonym: "1-FEH w1" RELATED [EC:3.2.1.153] +synonym: "1-FEH w2" RELATED [EC:3.2.1.153] +synonym: "1-fructan exohydrolase activity" RELATED [EC:3.2.1.153] +synonym: "beta-(2,1)-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.153] +synonym: "beta-(2,1)-fructan exohydrolase activity" RELATED [EC:3.2.1.153] +synonym: "beta-(2,1)-linkage-specific fructan-beta-fructosidase activity" RELATED [EC:3.2.1.153] +xref: EC:3.2.1.153 +xref: MetaCyc:3.2.1.153-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033949 +name: fructan beta-(2,6)-fructosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.154] +synonym: "6-FEH" RELATED [EC:3.2.1.154] +synonym: "beta-(2,6)-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.154] +synonym: "beta-(2,6)-fructan exohydrolase activity" RELATED [EC:3.2.1.154] +xref: EC:3.2.1.154 +xref: MetaCyc:3.2.1.154-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033950 +name: xyloglucan-specific exo-beta-1,4-glucanase activity +namespace: molecular_function +def: "Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan." [EC:3.2.1.155] +synonym: "[(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity" RELATED [EC:3.2.1.155] +synonym: "Cel74A" RELATED [EC:3.2.1.155] +xref: EC:3.2.1.155 +xref: MetaCyc:3.2.1.155-RXN +is_a: GO:0052736 ! beta-glucanase activity + +[Term] +id: GO:0033951 +name: oligosaccharide reducing-end xylanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides." [EC:3.2.1.156] +synonym: "beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity" RELATED [EC:3.2.1.156] +synonym: "reducing end xylose-releasing exo-oligoxylanase activity" RELATED [EC:3.2.1.156] +synonym: "Rex" RELATED [EC:3.2.1.156] +xref: EC:3.2.1.156 +xref: MetaCyc:3.2.1.156-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033952 +name: iota-carrageenase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." [EC:3.2.1.157] +synonym: "iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity" RELATED [EC:3.2.1.157] +xref: EC:3.2.1.157 +xref: MetaCyc:3.2.1.157-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033953 +name: alpha-agarase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product." [EC:3.2.1.158] +synonym: "agarase A33 activity" NARROW [EC:3.2.1.158] +synonym: "agarase activity" BROAD [EC:3.2.1.158] +synonym: "agarose 3-glycanohydrolase activity" BROAD [EC:3.2.1.158] +xref: EC:3.2.1.158 +xref: MetaCyc:3.2.1.158-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033954 +name: alpha-neoagaro-oligosaccharide hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose." [EC:3.2.1.159] +synonym: "alpha-NAOS hydrolase activity" RELATED [EC:3.2.1.159] +synonym: "alpha-neoagaro-oligosaccharide 3-glycohydrolase activity" RELATED [EC:3.2.1.159] +synonym: "alpha-neoagarooligosaccharide hydrolase activity" RELATED [EC:3.2.1.159] +xref: EC:3.2.1.159 +xref: MetaCyc:3.2.1.159-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033955 +name: obsolete mitochondrial DNA inheritance +namespace: biological_process +alt_id: GO:0090142 +def: "OBSOLETE. The process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission." [GOC:mah] +comment: This term was obsoleted because it represented a phenotype. +synonym: "mitochondrial chromosome segregation" RELATED [] +synonym: "mitochondrial DNA segregation" RELATED [] +is_obsolete: true +consider: GO:0000002 +consider: GO:0000266 + +[Term] +id: GO:0033956 +name: beta-apiosyl-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose." [EC:3.2.1.161] +synonym: "7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity" RELATED [EC:3.2.1.161] +synonym: "furcatin hydrolase activity" RELATED [EC:3.2.1.161] +synonym: "isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity" RELATED [EC:3.2.1.161] +synonym: "isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity" RELATED [EC:3.2.1.161] +xref: EC:3.2.1.161 +xref: MetaCyc:3.2.1.161-RXN +xref: MetaCyc:RXN-9156 +xref: RHEA:21488 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0033957 +name: lambda-carrageenase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S." [EC:3.2.1.162] +synonym: "endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity" RELATED [EC:3.2.1.162] +xref: EC:3.2.1.162 +xref: MetaCyc:3.2.1.162-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0033958 +name: DNA-deoxyinosine glycosylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine." [EC:3.2.2.15] +synonym: "deoxyribonucleic acid glycosylase activity" RELATED [EC:3.2.2.15] +synonym: "DNA(hypoxanthine) glycohydrolase activity" RELATED [EC:3.2.2.15] +synonym: "DNA-deoxyinosine deoxyribohydrolase activity" RELATED [EC:3.2.2.15] +synonym: "DNA-deoxyinosine glycosidase activity" RELATED [EC:3.2.2.15] +synonym: "hypoxanthine-DNA glycosylase activity" RELATED [EC:3.2.2.15] +xref: EC:3.2.2.15 +xref: MetaCyc:3.2.2.15-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0033959 +name: deoxyribodipyrimidine endonucleosidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue." [EC:3.2.2.17] +synonym: "deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity" RELATED [EC:3.2.2.17] +synonym: "deoxyribonucleate pyrimidine dimer glycosidase activity" RELATED [EC:3.2.2.17] +synonym: "endonuclease V activity" BROAD [EC:3.2.2.17] +synonym: "PD-DNA glycosylase activity" RELATED [EC:3.2.2.17] +synonym: "pyrimidine dimer DNA glycosylase activity" RELATED [EC:3.2.2.17] +synonym: "pyrimidine dimer DNA-glycosylase activity" RELATED [EC:3.2.2.17] +synonym: "T4-induced UV endonuclease activity" RELATED [EC:3.2.2.17] +xref: EC:3.2.2.17 +xref: MetaCyc:3.2.2.17-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0033960 +name: N-methyl nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose." [EC:3.2.2.25, RHEA:10880] +synonym: "7-methylxanthosine nucleosidase activity" RELATED [EC:3.2.2.25] +synonym: "7-methylxanthosine ribohydrolase activity" RELATED [EC:3.2.2.25] +synonym: "methylpurine nucleosidase activity" RELATED [EC:3.2.2.25] +synonym: "N-MeNase activity" RELATED [EC:3.2.2.25] +synonym: "N-methyl nucleoside hydrolase activity" RELATED [EC:3.2.2.25] +xref: EC:3.2.2.25 +xref: KEGG_REACTION:R07918 +xref: MetaCyc:RXN-7597 +xref: RHEA:10880 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0033961 +name: cis-stilbene-oxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] +subset: goslim_chembl +synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] +synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] +synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "cis-epoxide hydrolase activity" RELATED [EC:3.3.2.9] +synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] +synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] +synonym: "mEH" RELATED [EC:3.3.2.9] +synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] +synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] +synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] +xref: EC:3.3.2.9 +xref: MetaCyc:3.3.2.9-RXN +xref: Reactome:R-HSA-5694077 "EPHX1 hydrates BaP4,5O to BaP4,5-DHD" +xref: RHEA:23900 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0033962 +name: P-body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:mah, PMID:17429074] +synonym: "cytoplasmic mRNA processing body assembly" EXACT [] +synonym: "P body assembly" EXACT [] +synonym: "P body biogenesis" RELATED [] +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0033963 +name: cholesterol-5,6-oxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol." [EC:3.3.2.11] +synonym: "5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity" RELATED [EC:3.3.2.11] +synonym: "ChEH" RELATED [EC:3.3.2.11] +synonym: "cholesterol-epoxide hydrolase activity" RELATED [EC:3.3.2.11] +xref: EC:3.3.2.11 +xref: MetaCyc:RXN-8650 +xref: MetaCyc:RXN-8651 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0033964 +name: glycosphingolipid deacylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives." [EC:3.5.1.69] +synonym: "glycosphingolipid amidohydrolase activity" RELATED [EC:3.5.1.69] +synonym: "glycosphingolipid ceramide deacylase activity" BROAD [EC:3.5.1.69] +xref: EC:3.5.1.69 +xref: MetaCyc:3.5.1.69-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033965 +name: aculeacin-A deacylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain." [EC:3.5.1.70] +synonym: "aculeacin A acylase activity" RELATED [EC:3.5.1.70] +synonym: "aculeacin-A amidohydrolase activity" RELATED [EC:3.5.1.70] +xref: EC:3.5.1.70 +xref: MetaCyc:3.5.1.70-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033966 +name: N-substituted formamide deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine." [EC:3.5.1.91] +synonym: "N-benzylformamide amidohydrolase activity" RELATED [EC:3.5.1.91] +synonym: "NfdA" RELATED [EC:3.5.1.91] +xref: MetaCyc:3.5.1.91-RXN +xref: RHEA:12096 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033967 +name: box C/D RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving box C/D type small nucleolar RNA." [GOC:krc, GOC:mah] +synonym: "box C/D snoRNA metabolic process" NARROW [] +synonym: "box C/D sRNA metabolic process" NARROW [] +is_a: GO:0016074 ! sno(s)RNA metabolic process + +[Term] +id: GO:0033968 +name: glutaryl-7-aminocephalosporanic-acid acylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate." [EC:3.5.1.93] +synonym: "(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity" RELATED [EC:3.5.1.93] +synonym: "7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity" RELATED [EC:3.5.1.93] +synonym: "CA" RELATED [EC:3.5.1.93] +synonym: "cephalosporin acylase activity" RELATED [EC:3.5.1.93] +synonym: "cephalosporin C acylase activity" RELATED [EC:3.5.1.93] +synonym: "GA" RELATED [EC:3.5.1.93] +synonym: "GCA" RELATED [EC:3.5.1.93] +synonym: "GL-7-ACA acylase activity" RELATED [EC:3.5.1.93] +synonym: "glutaryl-7-ACA acylase activity" RELATED [EC:3.5.1.93] +synonym: "glutaryl-7-aminocephalosporanic acid acylase activity" RELATED [EC:3.5.1.93] +xref: EC:3.5.1.93 +xref: MetaCyc:3.5.1.93-RXN +xref: RHEA:23508 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033969 +name: gamma-glutamyl-gamma-aminobutyrate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate." [EC:3.5.1.94, RHEA:19737] +synonym: "4-(glutamylamino)butanoate amidohydrolase activity" RELATED [EC:3.5.1.94] +synonym: "gamma-glutamyl-GABA hydrolase activity" RELATED [EC:3.5.1.94] +synonym: "PuuD" RELATED [EC:3.5.1.94] +synonym: "YcjL" RELATED [EC:3.5.1.94] +xref: EC:3.5.1.94 +xref: KEGG_REACTION:R07419 +xref: MetaCyc:RXN0-3942 +xref: RHEA:19737 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033970 +name: N-malonylurea hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea." [EC:3.5.1.95, RHEA:17361] +synonym: "3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity" RELATED [EC:3.5.1.95] +synonym: "ureidomalonase activity" RELATED [EC:3.5.1.95] +xref: EC:3.5.1.95 +xref: KEGG_REACTION:R07629 +xref: MetaCyc:3.5.1.95-RXN +xref: RHEA:17361 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0033971 +name: hydroxyisourate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)." [EC:3.5.2.17, RHEA:23736] +synonym: "5-hydroxyisourate amidohydrolase activity" RELATED [EC:3.5.2.17] +synonym: "5-hydroxyisourate hydrolase activity" RELATED [EC:3.5.2.17] +synonym: "HIUHase activity" RELATED [EC:3.5.2.17] +xref: EC:3.5.2.17 +xref: KEGG_REACTION:R06601 +xref: MetaCyc:3.5.2.17-RXN +xref: RHEA:23736 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0033972 +name: proclavaminate amidinohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea." [EC:3.5.3.22, RHEA:17001] +synonym: "PAH" RELATED [EC:3.5.3.22] +synonym: "proclavaminate amidino hydrolase activity" RELATED [EC:3.5.3.22] +synonym: "proclavaminic acid amidino hydrolase activity" RELATED [EC:3.5.3.22] +xref: EC:3.5.3.22 +xref: KEGG_REACTION:R05357 +xref: MetaCyc:3.5.3.22-RXN +xref: RHEA:17001 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0033973 +name: dCTP deaminase (dUMP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+)." [EC:3.5.4.30, RHEA:19205] +synonym: "dCTP aminohydrolase (dUMP-forming) activity" RELATED [EC:3.5.4.30] +xref: EC:3.5.4.30 +xref: KEGG_REACTION:R07307 +xref: MetaCyc:3.5.4.30-RXN +xref: RHEA:19205 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0033974 +name: nucleoside phosphoacylhydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of mixed phospho-anhydride bonds." [EC:3.6.1.24] +synonym: "nucleoside-5'-phosphoacylate acylhydrolase activity" RELATED [EC:3.6.1.24] +xref: EC:3.6.1.24 +xref: MetaCyc:3.6.1.24-RXN +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0033975 +name: (R)-2-haloacid dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [EC:3.8.1.9] +synonym: "(R)-2-haloacid halidohydrolase activity" RELATED [EC:3.8.1.9] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.9] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [EC:3.8.1.9] +synonym: "D-2-haloacid dehalogenase activity" RELATED [EC:3.8.1.9] +synonym: "D-DEX" RELATED [EC:3.8.1.9] +xref: EC:3.8.1.9 +xref: MetaCyc:3.8.1.9-RXN +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033976 +name: 2-haloacid dehalogenase (configuration-inverting) activity +namespace: molecular_function +def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide." [GOC:curators] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [EC:3.8.1.10] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [] +synonym: "DL-2-haloacid dehalogenase (inversion of configuration) activity" RELATED [] +synonym: "DL-2-haloacid dehalogenase activity" BROAD [] +synonym: "DL-2-haloacid halidohydrolase (inversion of configuration) activity" RELATED [] +synonym: "DL-DEXi" RELATED [] +xref: MetaCyc:3.8.1.10-RXN +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033977 +name: 2-haloacid dehalogenase (configuration-retaining) activity +namespace: molecular_function +def: "Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [RHEA:12072] +synonym: "2-haloalkanoic acid dehalogenase activity" BROAD [] +synonym: "2-haloalkanoid acid halidohydrolase activity" BROAD [] +synonym: "DL-2-haloacid dehalogenase activity" BROAD [] +synonym: "DL-DEXr" RELATED [] +xref: EC:3.8.1.11 +xref: MetaCyc:3.8.1.11-RXN +xref: RHEA:12072 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0033978 +name: phosphonopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate." [EC:3.11.1.3, RHEA:16673] +synonym: "PPH" RELATED [EC:3.11.1.3] +xref: EC:3.11.1.3 +xref: KEGG_REACTION:R08200 +xref: MetaCyc:3.11.1.3-RXN +xref: RHEA:16673 +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0033979 +name: box H/ACA RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:krc, GOC:mah] +synonym: "box H/ACA snoRNA metabolic process" NARROW [] +synonym: "box H/ACA sRNA metabolic process" NARROW [] +is_a: GO:0016074 ! sno(s)RNA metabolic process + +[Term] +id: GO:0033980 +name: phosphonopyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde." [EC:4.1.1.82, RHEA:20768] +synonym: "3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity" RELATED [EC:4.1.1.82] +synonym: "3-phosphonopyruvate carboxy-lyase activity" RELATED [EC:4.1.1.82] +xref: EC:4.1.1.82 +xref: KEGG_REACTION:R04053 +xref: MetaCyc:4.1.1.82-RXN +xref: RHEA:20768 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033981 +name: D-dopachrome decarboxylase activity +namespace: molecular_function +alt_id: GO:0030928 +def: "Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2)." [EC:4.1.1.84, RHEA:18441] +synonym: "D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity" RELATED [EC:4.1.1.84] +synonym: "D-dopachrome carboxy-lyase activity" RELATED [EC:4.1.1.84] +synonym: "D-dopachrome tautomerase activity" RELATED [EC:4.1.1.84] +synonym: "D-tautomerase activity" RELATED [EC:4.1.1.84] +synonym: "dopachrome conversion activity" BROAD [] +synonym: "dopachrome decarboxylase activity" EXACT [] +synonym: "phenylpyruvate tautomerase II activity" RELATED [EC:4.1.1.84] +xref: EC:4.1.1.84 +xref: KEGG_REACTION:R07313 +xref: MetaCyc:4.1.1.84-RXN +xref: RHEA:18441 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033982 +name: 3-dehydro-L-gulonate-6-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2)." [EC:4.1.1.85, RHEA:14353] +synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity" RELATED [EC:4.1.1.85] +synonym: "3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.85] +synonym: "3-keto-L-gulonate 6-phosphate decarboxylase activity" RELATED [EC:4.1.1.85] +synonym: "KGPDC" RELATED [EC:4.1.1.85] +synonym: "SgaH" RELATED [EC:4.1.1.85] +synonym: "SgbH" RELATED [EC:4.1.1.85] +synonym: "UlaD" RELATED [EC:4.1.1.85] +xref: EC:4.1.1.85 +xref: KEGG_REACTION:R07125 +xref: MetaCyc:RXN0-705 +xref: RHEA:14353 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033983 +name: diaminobutyrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2)." [EC:4.1.1.86, RHEA:15689] +synonym: "DABA DC" RELATED [EC:4.1.1.86] +synonym: "L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity" RELATED [EC:4.1.1.86] +synonym: "L-2,4-diaminobutanoate carboxy-lyase activity" RELATED [EC:4.1.1.86] +synonym: "L-2,4-diaminobutyrate decarboxylase activity" RELATED [EC:4.1.1.86] +xref: EC:4.1.1.86 +xref: KEGG_REACTION:R07650 +xref: MetaCyc:4.1.1.86-RXN +xref: RHEA:15689 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0033984 +name: indole-3-glycerol-phosphate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate." [EC:4.1.2.8] +synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity" RELATED [EC:4.1.2.8] +synonym: "(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.8] +synonym: "BX1" RELATED [EC:4.1.2.8] +synonym: "IGL" RELATED [EC:4.1.2.8] +synonym: "indole glycerol phosphate hydrolase activity" RELATED [EC:4.1.2.8] +synonym: "indole synthase activity" RELATED [EC:4.1.2.8] +synonym: "indole-3-glycerol phosphate lyase activity" RELATED [EC:4.1.2.8] +synonym: "indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity" RELATED [EC:4.1.2.8] +synonym: "indoleglycerolphosphate aldolase activity" RELATED [EC:4.1.2.8] +synonym: "tryptophan synthase alpha activity" NARROW [EC:4.1.2.8] +synonym: "tryptophan synthase alpha subunit activity" NARROW [EC:4.1.2.8] +synonym: "TSA" RELATED [EC:4.1.2.8] +xref: EC:4.1.2.8 +xref: KEGG_REACTION:R02340 +xref: MetaCyc:4.1.2.8-RXN +xref: MetaCyc:RXN0-2381 +xref: RHEA:14081 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0033985 +name: acidocalcisome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of an acidocalcisome." [GOC:mah] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0020022 ! acidocalcisome + +[Term] +id: GO:0033986 +name: response to methanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:sl] +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0033987 +name: 2-hydroxyisoflavanone dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O." [EC:4.2.1.105] +synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity" RELATED [EC:4.2.1.105] +synonym: "2,7,4'-trihydroxyisoflavanone hydro-lyase activity" RELATED [EC:4.2.1.105] +xref: EC:4.2.1.105 +xref: MetaCyc:RXN-3284 +xref: RHEA:16445 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033988 +name: bile-acid 7alpha-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O." [EC:4.2.1.106, RHEA:10436] +synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity" RELATED [EC:4.2.1.106] +synonym: "7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity" RELATED [EC:4.2.1.106] +synonym: "BA7 alpha dehydratase activity" RELATED [EC:4.2.1.106] +xref: EC:4.2.1.106 +xref: KEGG_REACTION:R07318 +xref: MetaCyc:4.2.1.106-RXN +xref: RHEA:10436 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033989 +name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O." [EC:4.2.1.107] +synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity" RELATED [EC:4.2.1.107] +synonym: "(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.107] +synonym: "46 kDa hydratase 2 activity" RELATED [EC:4.2.1.107] +synonym: "D-3-hydroxyacyl-CoA dehydratase activity" BROAD [EC:4.2.1.107] +xref: EC:4.2.1.107 +xref: MetaCyc:4.2.1.107-RXN +xref: Reactome:R-HSA-192331 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" +xref: Reactome:R-HSA-193535 "25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" +xref: RHEA:18933 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033990 +name: ectoine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O." [EC:4.2.1.108, RHEA:17281] +synonym: "4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" RELATED [EC:4.2.1.108] +synonym: "EctC" RELATED [EC:4.2.1.108] +synonym: "L-ectoine synthase activity" RELATED [EC:4.2.1.108] +synonym: "N-acetyldiaminobutanoate dehydratase activity" RELATED [EC:4.2.1.108] +synonym: "N-acetyldiaminobutyrate dehydratase activity" RELATED [EC:4.2.1.108] +synonym: "N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity" RELATED [EC:4.2.1.108] +xref: EC:4.2.1.108 +xref: KEGG_REACTION:R06979 +xref: MetaCyc:R103-RXN +xref: RHEA:17281 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033991 +name: aldos-2-ulose dehydratase activity +namespace: molecular_function +def: "Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one." [EC:4.2.1.110] +synonym: "1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity" RELATED [EC:4.2.1.110] +synonym: "1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity" RELATED [EC:4.2.1.110] +synonym: "AUDH" RELATED [EC:4.2.1.110] +synonym: "pyranosone dehydratase activity" RELATED [EC:4.2.1.110] +xref: EC:4.2.1.110 +xref: MetaCyc:4.2.1.110-RXN +xref: RHEA:12100 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033992 +name: 1,5-anhydro-D-fructose dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O." [EC:4.2.1.111] +synonym: "1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity" RELATED [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose 4-dehydratase activity" RELATED [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity" RELATED [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydro-lyase activity" RELATED [EC:4.2.1.111] +synonym: "1,5-anhydro-D-fructose hydrolyase activity" RELATED [EC:4.2.1.111] +synonym: "AF dehydratase activity" RELATED [EC:4.2.1.111] +synonym: "AFDH" RELATED [EC:4.2.1.111] +xref: EC:4.2.1.111 +xref: MetaCyc:4.2.1.111-RXN +xref: RHEA:15725 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0033993 +name: response to lipid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:sl] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0033994 +name: glucuronan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides." [EC:4.2.2.14] +synonym: "(1,4)-beta-D-glucuronan lyase activity" RELATED [EC:4.2.2.14] +xref: EC:4.2.2.14 +xref: MetaCyc:4.2.2.14-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033995 +name: anhydrosialidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate." [EC:4.2.2.15] +synonym: "anhydroneuraminidase activity" RELATED [EC:4.2.2.15] +synonym: "glycoconjugate sialyl-lyase (2,7-cyclizing) activity" RELATED [EC:4.2.2.15] +synonym: "sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity" RELATED [EC:4.2.2.15] +synonym: "sialidase L activity" RELATED [EC:4.2.2.15] +xref: EC:4.2.2.15 +xref: MetaCyc:4.2.2.15-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033996 +name: levan fructotransferase (DFA-IV-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.16] +synonym: "2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity" RELATED [EC:4.2.2.16] +synonym: "2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity" RELATED [EC:4.2.2.16] +synonym: "levan fructotransferase activity" RELATED [EC:4.2.2.16] +xref: EC:4.2.2.16 +xref: MetaCyc:4.2.2.16-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033997 +name: inulin fructotransferase (DFA-I-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.17] +synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity" RELATED [EC:4.2.2.17] +synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity" RELATED [EC:4.2.2.17] +synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity" RELATED [EC:4.2.2.17] +synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity" RELATED [EC:4.2.2.17] +synonym: "inulin fructotransferase (DFA-I-producing) activity" RELATED [EC:4.2.2.17] +xref: EC:4.2.2.17 +xref: MetaCyc:4.2.2.17-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033998 +name: inulin fructotransferase (DFA-III-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide." [EC:4.2.2.18] +synonym: "2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18] +synonym: "inulase II activity" RELATED [EC:4.2.2.18] +synonym: "inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18] +synonym: "inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity" RELATED [EC:4.2.2.18] +synonym: "inulin fructotransferase (depolymerizing) activity" RELATED [EC:4.2.2.18] +synonym: "inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity" RELATED [EC:4.2.2.18] +synonym: "inulin fructotransferase (DFA-III-producing) activity" RELATED [EC:4.2.2.18] +synonym: "inulinase II activity" RELATED [EC:4.2.2.18] +xref: EC:4.2.2.18 +xref: MetaCyc:4.2.2.18-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0033999 +name: chondroitin B lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate." [EC:4.2.2.19] +synonym: "ChnB" RELATED [EC:4.2.2.19] +synonym: "chonB" RELATED [EC:4.2.2.19] +synonym: "chondroitinase B activity" RELATED [EC:4.2.2.19] +synonym: "dermatan sulfate lyase activity" EXACT [] +xref: EC:4.2.2.19 +xref: MetaCyc:4.2.2.19-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0034000 +name: chondroitin-sulfate-ABC endolyase activity +namespace: molecular_function +def: "Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides." [EC:4.2.2.20] +synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC endoeliminase activity" RELATED [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC endolyase activity" RELATED [EC:4.2.2.20] +synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.20] +synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.20] +synonym: "chondroitinase activity" BROAD [EC:4.2.2.20] +synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.20] +synonym: "ChS ABC lyase I activity" RELATED [EC:4.2.2.20] +xref: EC:4.2.2.20 +xref: MetaCyc:4.2.2.20-RXN +is_a: GO:0047486 ! chondroitin ABC lyase activity + +[Term] +id: GO:0034001 +name: chondroitin-sulfate-ABC exolyase activity +namespace: molecular_function +def: "Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments." [EC:4.2.2.21] +synonym: "chondroitin ABC eliminase activity" BROAD [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC exoeliminase activity" RELATED [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC exolyase activity" RELATED [EC:4.2.2.21] +synonym: "chondroitin sulfate ABC lyase activity" BROAD [EC:4.2.2.21] +synonym: "chondroitinase ABC activity" BROAD [EC:4.2.2.21] +synonym: "chondroitinase activity" BROAD [EC:4.2.2.21] +synonym: "ChS ABC lyase activity" BROAD [EC:4.2.2.21] +synonym: "ChS ABC lyase II activity" RELATED [EC:4.2.2.21] +xref: EC:4.2.2.21 +xref: MetaCyc:4.2.2.21-RXN +is_a: GO:0047486 ! chondroitin ABC lyase activity + +[Term] +id: GO:0034002 +name: (R)-limonene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate." [EC:4.2.3.20, RHEA:10940] +synonym: "(+)-limonene synthase activity" RELATED [EC:4.2.3.20] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity" RELATED [EC:4.2.3.20] +synonym: "geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity" RELATED [EC:4.2.3.20] +xref: EC:4.2.3.20 +xref: KEGG_REACTION:R06120 +xref: MetaCyc:4.2.3.20-RXN +xref: RHEA:10940 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0034003 +name: vetispiradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene." [EC:4.2.3.21, RHEA:10340] +synonym: "HVS" RELATED [EC:4.2.3.21] +synonym: "pemnaspirodiene synthase activity" RELATED [EC:4.2.3.21] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity" RELATED [EC:4.2.3.21] +synonym: "vetispiradiene cyclase activity" RELATED [EC:4.2.3.21] +synonym: "vetispiradiene-forming farnesyl pyrophosphate cyclase activity" RELATED [EC:4.2.3.21] +xref: EC:4.2.3.21 +xref: KEGG_REACTION:R06523 +xref: MetaCyc:RXN-4823 +xref: RHEA:10340 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0034004 +name: germacradienol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate." [EC:4.2.3.22] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity" RELATED [EC:4.2.3.22] +xref: EC:4.2.3.22 +xref: KEGG_REACTION:R07647 +xref: MetaCyc:RXN-8648 +xref: RHEA:22436 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034005 +name: germacrene-A synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate." [EC:4.2.3.23, RHEA:12516] +synonym: "(+)-(10R)-germacrene A synthase activity" RELATED [EC:4.2.3.23] +synonym: "(+)-germacrene A synthase activity" RELATED [EC:4.2.3.23] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity" RELATED [EC:4.2.3.23] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity" RELATED [EC:4.2.3.23] +synonym: "GAS" RELATED [EC:4.2.3.23] +synonym: "germacrene A synthase activity" RELATED [EC:4.2.3.23] +xref: EC:4.2.3.23 +xref: KEGG_REACTION:R07649 +xref: MetaCyc:4.2.3.23-RXN +xref: RHEA:12516 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0034006 +name: amorpha-4,11-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate." [EC:4.2.3.24, RHEA:18325] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity" RELATED [EC:4.2.3.24] +synonym: "amorphadiene synthase activity" RELATED [EC:4.2.3.24] +xref: EC:4.2.3.24 +xref: KEGG_REACTION:R07630 +xref: MetaCyc:4.2.3.24-RXN +xref: MetaCyc:RXN-8046 +xref: RHEA:18325 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0034007 +name: S-linalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate." [EC:4.2.3.25, RHEA:24116] +synonym: "3S-linalool synthase activity" RELATED [EC:4.2.3.25] +synonym: "geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity" RELATED [EC:4.2.3.25] +synonym: "LIS" RELATED [EC:4.2.3.25] +xref: EC:4.2.3.25 +xref: KEGG_REACTION:R07631 +xref: MetaCyc:4.2.3.25-RXN +xref: RHEA:24116 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034008 +name: R-linalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate." [EC:4.2.3.26, RHEA:15809] +synonym: "(-)-3R-linalool synthase activity" RELATED [EC:4.2.3.26] +synonym: "(3R)-linalool synthase activity" RELATED [EC:4.2.3.26] +synonym: "geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity" RELATED [EC:4.2.3.26] +xref: EC:4.2.3.26 +xref: KEGG_REACTION:R07632 +xref: MetaCyc:4.2.3.26-RXN +xref: RHEA:15809 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034009 +name: isoprene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene." [EC:4.2.3.27, RHEA:13369] +synonym: "dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity" RELATED [EC:4.2.3.27] +synonym: "ISPC" RELATED [EC:4.2.3.27] +synonym: "ISPS" RELATED [EC:4.2.3.27] +xref: EC:4.2.3.27 +xref: KEGG_REACTION:R08199 +xref: MetaCyc:4.2.3.27-RXN +xref: RHEA:13369 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0034010 +name: sulfolactate sulfo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite." [EC:4.4.1.24, RHEA:21428] +synonym: "3-sulfolactate bisulfite-lyase (pyruvate-forming) activity" RELATED [EC:4.4.1.24] +synonym: "3-sulfolactate bisulfite-lyase activity" RELATED [EC:4.4.1.24] +synonym: "Suy" RELATED [EC:4.4.1.24] +synonym: "SuyAB" RELATED [EC:4.4.1.24] +xref: EC:4.4.1.24 +xref: KEGG_REACTION:R07633 +xref: MetaCyc:4.4.1.24-RXN +xref: RHEA:21428 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034011 +name: L-cysteate sulfo-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite." [EC:4.4.1.25, RHEA:13441] +synonym: "CuyA" RELATED [EC:4.4.1.25] +synonym: "L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity" RELATED [EC:4.4.1.25] +synonym: "L-cysteate sulfo-lyase (deaminating) activity" RELATED [EC:4.4.1.25] +xref: EC:4.4.1.25 +xref: KEGG_REACTION:R07634 +xref: MetaCyc:4.4.1.25-RXN +xref: RHEA:13441 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034012 +name: FAD-AMP lyase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate." [EC:4.6.1.15] +synonym: "FAD AMP-lyase (cyclic-FMN-forming) activity" RELATED [EC:4.6.1.15] +synonym: "FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity" RELATED [EC:4.6.1.15] +synonym: "FMN cyclase activity" RELATED [EC:4.6.1.15] +xref: EC:4.6.1.15 +xref: RHEA:13729 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0034013 +name: aliphatic aldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O." [EC:4.99.1.5] +synonym: "aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity" RELATED [EC:4.99.1.5] +synonym: "aliphatic aldoxime hydro-lyase activity" RELATED [EC:4.99.1.5] +synonym: "OxdA" RELATED [EC:4.99.1.5] +xref: EC:4.99.1.5 +xref: MetaCyc:4.99.1.5-RXN +xref: RHEA:11316 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0034014 +name: response to triglyceride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:sl] +synonym: "response to triacylglyceride" EXACT [] +synonym: "response to triacylglycerol" EXACT [] +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0034015 +name: L-ribulose-5-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate." [EC:5.1.3.22, RHEA:18497] +synonym: "L-xylulose 5-phosphate 3-epimerase activity" RELATED [EC:5.1.3.22] +synonym: "SgaU" RELATED [EC:5.1.3.22] +synonym: "UlaE" RELATED [EC:5.1.3.22] +xref: EC:5.1.3.22 +xref: MetaCyc:LXULRU5P-RXN +xref: RHEA:18497 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0034016 +name: polyenoic fatty acid isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate." [EC:5.3.3.13, RHEA:14889] +synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity" RELATED [EC:5.3.3.13] +synonym: "(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" RELATED [EC:5.3.3.13] +synonym: "(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity" RELATED [EC:5.3.3.13] +synonym: "eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity" RELATED [EC:5.3.3.13] +synonym: "PFI" RELATED [EC:5.3.3.13] +xref: EC:5.3.3.13 +xref: KEGG_REACTION:R06502 +xref: MetaCyc:5.3.3.13-RXN +xref: RHEA:14889 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034017 +name: trans-2-decenoyl-acyl-carrier-protein isomerase activity +namespace: molecular_function +alt_id: GO:0043832 +def: "Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]." [EC:5.3.3.14] +synonym: "beta-hydroxydecanoyl thioester dehydrase activity" BROAD [EC:5.3.3.14] +synonym: "decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity" RELATED [EC:5.3.3.14] +synonym: "FabM" RELATED [EC:5.3.3.14] +synonym: "trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity" EXACT [] +synonym: "trans-2, cis-3 decenoyl-ACP isomerase activity" EXACT [] +synonym: "trans-2,cis-3-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14] +synonym: "trans-2-cis-3-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14] +synonym: "trans-2-decenoyl-ACP isomerase activity" RELATED [EC:5.3.3.14] +xref: EC:5.3.3.14 +xref: MetaCyc:5.3.3.14-RXN +xref: RHEA:23568 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034018 +name: ascopyrone tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose." [EC:5.3.2.7] +synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity" RELATED [EC:5.3.2.7] +synonym: "1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity" RELATED [EC:5.3.2.7] +synonym: "APM tautomerase activity" RELATED [EC:5.3.2.7] +synonym: "APTM" RELATED [EC:5.3.2.7] +synonym: "ascopyrone intramolecular oxidoreductase activity" RELATED [EC:5.3.2.7] +synonym: "ascopyrone isomerase activity" RELATED [EC:5.3.2.7] +synonym: "ascopyrone P tautomerase activity" RELATED [EC:5.3.2.7] +xref: EC:5.3.2.7 +xref: MetaCyc:5.3.3.15-RXN +xref: RHEA:22568 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0034019 +name: obsolete capsanthin/capsorubin synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: violaxanthin = capsorubin, and antheraxanthin = capsanthin." [EC:5.3.99.8] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "capsanthin-capsorubin synthase activity" RELATED [EC:5.3.99.8] +synonym: "capsanthin/capsorubin synthase activity" EXACT [] +synonym: "CCS" RELATED [EC:5.3.99.8] +synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] +synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" NARROW [EC:5.3.99.8] +is_obsolete: true +consider: GO:0052727 +consider: GO:0052728 + +[Term] +id: GO:0034020 +name: neoxanthin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin." [EC:5.3.99.9, RHEA:10128] +synonym: "NSY" RELATED [EC:5.3.99.9] +synonym: "violaxanthin-neoxanthin isomerase (epoxide-opening) activity" RELATED [EC:5.3.99.9] +xref: EC:5.3.99.9 +xref: KEGG_REACTION:R06948 +xref: MetaCyc:RXN1F-155 +xref: RHEA:10128 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034021 +name: response to silicon dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:sl] +synonym: "response to silica" EXACT [] +synonym: "response to silox" EXACT [] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0034022 +name: 3-(hydroxyamino)phenol mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone." [EC:5.4.4.3, RHEA:20577] +synonym: "3-(hydroxyamino)phenol hydroxymutase activity" RELATED [EC:5.4.4.3] +synonym: "3-hydroxylaminophenol mutase activity" RELATED [EC:5.4.4.3] +synonym: "3HAP mutase activity" RELATED [EC:5.4.4.3] +xref: EC:5.4.4.3 +xref: KEGG_REACTION:R06988 +xref: MetaCyc:5.4.4.3-RXN +xref: RHEA:20577 +xref: UM-BBD_enzymeID:e0953 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0034023 +name: 5-(carboxyamino)imidazole ribonucleotide mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate." [EC:5.4.99.18] +synonym: "5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity" RELATED [EC:5.4.99.18] +synonym: "class I PurE" RELATED [EC:5.4.99.18] +synonym: "N5-CAIR mutase activity" RELATED [EC:5.4.99.18] +synonym: "N5-carboxyaminoimidazole ribonucleotide mutase activity" RELATED [EC:5.4.99.18] +synonym: "PurE" RELATED [EC:5.4.99.18] +xref: EC:5.4.99.18 +xref: MetaCyc:5.4.99.18-RXN +xref: RHEA:13193 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034024 +name: glutamate-putrescine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate." [EC:6.3.1.11, RHEA:13633] +synonym: "gamma-glutamylputrescine synthetase activity" RELATED [EC:6.3.1.11] +synonym: "L-glutamate:putrescine ligase (ADP-forming) activity" RELATED [EC:6.3.1.11] +synonym: "YcjK" RELATED [EC:6.3.1.11] +xref: EC:6.3.1.11 +xref: KEGG_REACTION:R07414 +xref: MetaCyc:RXN0-3901 +xref: RHEA:13633 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0034025 +name: D-aspartate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate." [EC:6.3.1.12] +synonym: "aslfm" RELATED [EC:6.3.1.12] +synonym: "D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity" RELATED [EC:6.3.1.12] +synonym: "D-aspartic acid-activating enzyme" RELATED [EC:6.3.1.12] +synonym: "UDP-MurNAc-pentapeptide:D-aspartate ligase activity" RELATED [EC:6.3.1.12] +xref: EC:6.3.1.12 +xref: MetaCyc:6.3.1.12-RXN +xref: RHEA:10752 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0034026 +name: L-amino-acid alpha-ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid." [EC:6.3.2.49] +synonym: "bacilysin synthetase activity" EXACT [] +synonym: "L-amino acid alpha-ligase activity" EXACT [] +synonym: "L-amino acid ligase activity" EXACT [] +synonym: "YwfE" RELATED [] +xref: EC:6.3.2.49 +xref: MetaCyc:6.3.2.28-RXN +xref: RHEA:44332 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0034027 +name: (carboxyethyl)arginine beta-lactam-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+)." [EC:6.3.3.4, RHEA:23620] +synonym: "beta-lactam synthetase activity" RELATED [EC:6.3.3.4] +synonym: "L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" RELATED [EC:6.3.3.4] +synonym: "L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity" RELATED [EC:6.3.3.4] +xref: EC:6.3.3.4 +xref: KEGG_REACTION:R05467 +xref: MetaCyc:6.3.3.4-RXN +xref: RHEA:23620 +is_a: GO:0016882 ! cyclo-ligase activity + +[Term] +id: GO:0034028 +name: 5-(carboxyamino)imidazole ribonucleotide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate." [EC:6.3.4.18, RHEA:19317] +synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity" RELATED [EC:6.3.4.18] +synonym: "N5-CAIR synthetase activity" RELATED [EC:6.3.4.18] +synonym: "N5-carboxyaminoimidazole ribonucleotide synthetase activity" RELATED [EC:6.3.4.18] +synonym: "PurK" RELATED [EC:6.3.4.18] +xref: EC:6.3.4.18 +xref: KEGG_REACTION:R07404 +xref: MetaCyc:RXN0-742 +xref: RHEA:19317 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0034029 +name: 2-oxoglutarate carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate." [EC:6.4.1.7, RHEA:20425] +synonym: "carboxylating factor for ICDH" RELATED [EC:6.4.1.7] +synonym: "CFI" RELATED [EC:6.4.1.7] +synonym: "OGC" RELATED [EC:6.4.1.7] +synonym: "oxalosuccinate synthetase activity" RELATED [EC:6.4.1.7] +xref: EC:6.4.1.7 +xref: KEGG_REACTION:R08201 +xref: MetaCyc:RXN-8457 +xref: RHEA:20425 +is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds + +[Term] +id: GO:0034030 +name: ribonucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "ribonucleoside bisphosphate anabolism" EXACT [] +synonym: "ribonucleoside bisphosphate biosynthesis" EXACT [] +synonym: "ribonucleoside bisphosphate formation" EXACT [] +synonym: "ribonucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034031 +name: ribonucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside bisphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "ribonucleoside bisphosphate breakdown" EXACT [] +synonym: "ribonucleoside bisphosphate catabolism" EXACT [] +synonym: "ribonucleoside bisphosphate degradation" EXACT [] +is_a: GO:0033869 ! nucleoside bisphosphate catabolic process +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034032 +name: purine nucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine nucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0033865 ! nucleoside bisphosphate metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0034033 +name: purine nucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine nucleoside bisphosphate anabolism" EXACT [] +synonym: "purine nucleoside bisphosphate biosynthesis" EXACT [] +synonym: "purine nucleoside bisphosphate formation" EXACT [] +synonym: "purine nucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0033866 ! nucleoside bisphosphate biosynthetic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0034034 +name: purine nucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleoside bisphosphate, a compound consisting of a purine base linked to a deoxyribose or ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine nucleoside bisphosphate breakdown" EXACT [] +synonym: "purine nucleoside bisphosphate catabolism" EXACT [] +synonym: "purine nucleoside bisphosphate degradation" EXACT [] +is_a: GO:0033869 ! nucleoside bisphosphate catabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process + +[Term] +id: GO:0034035 +name: purine ribonucleoside bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine ribonucleoside bisphosphate metabolism" EXACT [] +is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process +is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process + +[Term] +id: GO:0034036 +name: purine ribonucleoside bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine ribonucleoside bisphosphate anabolism" EXACT [] +synonym: "purine ribonucleoside bisphosphate biosynthesis" EXACT [] +synonym: "purine ribonucleoside bisphosphate formation" EXACT [] +synonym: "purine ribonucleoside bisphosphate synthesis" EXACT [] +is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process +is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034037 +name: purine ribonucleoside bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." [GOC:mah, GOC:pde] +synonym: "purine ribonucleoside bisphosphate breakdown" EXACT [] +synonym: "purine ribonucleoside bisphosphate catabolism" EXACT [] +synonym: "purine ribonucleoside bisphosphate degradation" EXACT [] +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process + +[Term] +id: GO:0034038 +name: deoxyhypusine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [GOC:pde, RHEA:33299] +comment: Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'. +synonym: "(4-aminobutyl)lysine synthase" BROAD [EC:2.5.1.46] +synonym: "eIF-5A-deoxyhypusine synthase activity" RELATED [EC:2.5.1.46] +synonym: "spermidine dehydrogenase" BROAD [EC:2.5.1.46] +xref: EC:2.5.1.46 +xref: MetaCyc:2.5.1.46-RXN +xref: Reactome:R-HSA-204617 "DHPS tetramer synthesizes EIF5A and spermidine from Dhp-K50-EIF5A" +xref: Reactome:R-HSA-204647 "DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine" +xref: RHEA:33299 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0034039 +name: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "8-oxoG DNA N-glycosylase activity" EXACT [] +is_a: GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity + +[Term] +id: GO:0034040 +name: ATPase-coupled lipid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out)." [GOC:BHF, GOC:rl] +synonym: "ATP-dependent lipid transmembrane transporter activity" EXACT [] +synonym: "lipid-transporting ATPase activity" BROAD [] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0034041 +name: ABC-type sterol transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sterol(in) = ADP + phosphate + sterol(out)." [GOC:BHF, GOC:rl] +synonym: "ATP-coupled sterol transmembrane transporter activity" RELATED [] +synonym: "ATP-dependent sterol transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled sterol transmembrane transporter activity" RELATED [] +synonym: "sterol-transporting ATPase activity" RELATED [] +is_a: GO:0015248 ! sterol transporter activity +is_a: GO:0034040 ! ATPase-coupled lipid transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0034042 +name: 5-formyluracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "5-foU DNA N-glycosylase activity" EXACT [] +is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity + +[Term] +id: GO:0034043 +name: 5-hydroxymethyluracil DNA N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar." [GOC:mah, PMID:17641464] +synonym: "5-hmU DNA N-glycosylase activity" EXACT [] +is_a: GO:0000703 ! oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity + +[Term] +id: GO:0034044 +name: exomer complex +namespace: cellular_component +def: "A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues." [PMID:16498409, PMID:17000877] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005794 ! Golgi apparatus +relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle + +[Term] +id: GO:0034045 +name: phagophore assembly site membrane +namespace: cellular_component +def: "A cellular membrane associated with the phagophore assembly site." [GOC:mah, GOC:rph, PMID:16874040, PMID:17382324] +synonym: "isolation membrane" RELATED [] +synonym: "PAS membrane" EXACT [] +synonym: "phagophore" RELATED [PMID:20811355] +synonym: "pre-autophagosomal structure membrane" NARROW [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0000407 ! phagophore assembly site + +[Term] +id: GO:0034046 +name: poly(G) binding +namespace: molecular_function +def: "Binding to a sequence of guanine residues in an RNA molecule." [GOC:mah] +synonym: "poly(G) binding, within an RNA molecule" EXACT [] +synonym: "poly(rG) binding" EXACT [GOC:mah] +is_a: GO:0070717 ! poly-purine tract binding + +[Term] +id: GO:0034050 +name: programmed cell death induced by symbiont +namespace: biological_process +def: "Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules." [GOC:pamgo_curators] +comment: Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'positive regulation by symbiont of host programmed cell death ; GO:0052042'. +synonym: "'host programmed cell death induced by symbiont'" EXACT [] +is_a: GO:0012501 ! programmed cell death +is_a: GO:0051702 ! biological process involved in interaction with symbiont +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0034051 +name: negative regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] +synonym: "down regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "down-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "downregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "inhibition of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "negative regulation of HR" EXACT [GOC:pamgo_curators] +synonym: "negative regulation of HR-PCD" EXACT [GOC:pamgo_curators] +synonym: "negative regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] +is_a: GO:0010363 ! regulation of plant-type hypersensitive response +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0034052 +name: positive regulation of plant-type hypersensitive response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the hypersensitive response in a plant." [GOC:pamgo_curators] +synonym: "activation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "positive regulation of HR" EXACT [GOC:pamgo_curators] +synonym: "positive regulation of HR-PCD" RELATED [GOC:pamgo_curators] +synonym: "positive regulation of plant hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "stimulation of plant-type hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "up regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "up-regulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +synonym: "upregulation of plant-type hypersensitive response" EXACT [GOC:pamgo_curators] +is_a: GO:0010363 ! regulation of plant-type hypersensitive response +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0009626 ! plant-type hypersensitive response + +[Term] +id: GO:0034053 +name: modulation by symbiont of host defense-related programmed cell death +namespace: biological_process +def: "Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'. +synonym: "modulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "modulation by symbiont of host HR" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of host hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] +synonym: "modulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death + +[Term] +id: GO:0034054 +name: suppression by symbiont of host defense-related programmed cell death +namespace: biological_process +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'. +synonym: "down regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "down-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "downregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "inhibition by symbiont of host defense-related PCD" NARROW [GOC:pamgo_curators] +synonym: "inhibition by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "inhibition of host defense-related PCD" NARROW [GOC:pamgo_curators] +synonym: "inhibition of HR" NARROW [GOC:pamgo_curators] +synonym: "inhibition of hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of host defense-related programmed cell death" EXACT [] +synonym: "negative regulation by symbiont of plant HR" NARROW [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of plant hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "suppression of HR" NARROW [GOC:pamgo_curators] +is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052041 ! negative regulation by symbiont of host programmed cell death + +[Term] +id: GO:0034055 +name: effector-mediated induction of programmed cell death in host +namespace: biological_process +def: "A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "activation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "enhancement by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of host defense-related PCD" EXACT [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of host defense-related programmed cell death" RELATED [] +synonym: "stimulation by symbiont of host defense-related programmed cell death" NARROW [GOC:pamgo_curators] +synonym: "up regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "up-regulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +synonym: "upregulation by symbiont of host defense-related programmed cell death" EXACT [GOC:pamgo_curators] +is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052170 ! suppression by symbiont of host innate immune response +is_a: GO:0140418 ! effector-mediated modulation of host process by symbiont + +[Term] +id: GO:0034056 +name: estrogen response element binding +namespace: molecular_function +def: "Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen." [GOC:ecd, PMID:15036253, PMID:17975005] +synonym: "ERE binding" EXACT [] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0034057 +name: RNA strand-exchange activity +namespace: molecular_function +def: "Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity." [GOC:mcc, PMID:9769100] +is_a: GO:0003725 ! double-stranded RNA binding +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0034058 +name: endosomal vesicle fusion +namespace: biological_process +def: "The homotypic fusion of endocytic vesicles to form or add to an early endosome." [PMID:11964142, PMID:9422733] +synonym: "endosome vesicle fusion" EXACT [] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:0034059 +name: response to anoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:kmv] +comment: Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. +synonym: "response to anoxic stress" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0036293 ! response to decreased oxygen levels + +[Term] +id: GO:0034060 +name: cyanelle stroma +namespace: cellular_component +def: "The space enclosed by the double membrane of a cyanelle." [GOC:rph] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0009842 ! cyanelle + +[Term] +id: GO:0034061 +name: DNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:mah] +synonym: "deoxynucleate polymerase activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleic acid polymerase activity" RELATED [EC:2.7.7.7] +synonym: "deoxyribonucleic polymerase activity" RELATED [EC:2.7.7.7] +synonym: "DNA nucleotidyltransferase activity" RELATED [EC:2.7.7.7] +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0034062 +name: 5'-3' RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end." [EC:2.7.7.6, GOC:mah, GOC:pf] +synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] +synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] +synonym: "ribonucleate nucleotidyltransferase activity" RELATED [EC:2.7.7.6] +synonym: "ribonucleate polymerase activity" RELATED [EC:2.7.7.6] +synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] +synonym: "ribonucleic acid polymerase activity" RELATED [EC:2.7.7.6] +synonym: "ribonucleic acid transcriptase activity" RELATED [EC:2.7.7.6] +synonym: "ribonucleic polymerase activity" RELATED [EC:2.7.7.6] +synonym: "ribonucleic transcriptase activity" RELATED [EC:2.7.7.6] +synonym: "RNA nucleotidyltransferase activity" RELATED [EC:2.7.7.6] +synonym: "RNA polymerase activity" BROAD [] +synonym: "RNA transcriptase activity" RELATED [EC:2.7.7.6] +synonym: "transcriptase" BROAD [EC:2.7.7.6] +xref: Reactome:R-HSA-5696807 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" +xref: Reactome:R-HSA-6786881 "TRNT1 polymerizes CCA at the 3' end of pre-tRNA" +is_a: GO:0097747 ! RNA polymerase activity + +[Term] +id: GO:0034063 +name: stress granule assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] +synonym: "SG assembly" EXACT [PMID:19825938] +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0034064 +name: Tor2-Mei2-Ste11 complex +namespace: cellular_component +def: "A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast." [GOC:vw, PMID:17046992] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034066 +name: Ric1-Rgp1 guanyl-nucleotide exchange factor complex +namespace: cellular_component +def: "A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi." [GOC:jh, GOC:mah, PMID:10990452] +synonym: "Ric1p-Rgp1p complex" RELATED [] +is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0034067 +name: protein localization to Golgi apparatus +namespace: biological_process +alt_id: GO:0000042 +alt_id: GO:0072600 +def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] +synonym: "establishment of protein localisation to Golgi" NARROW [GOC:mah] +synonym: "establishment of protein localization in Golgi" NARROW [] +synonym: "establishment of protein localization to Golgi" NARROW [] +synonym: "establishment of protein localization to Golgi apparatus" NARROW [GOC:mah] +synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] +synonym: "protein localization in Golgi apparatus" EXACT [] +synonym: "protein targeting to Golgi" RELATED [] +synonym: "protein-Golgi targeting" RELATED [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0034068 +name: aminoglycoside nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside." [GOC:cb] +synonym: "aminoglycoside adenylyltransferase activity" NARROW [] +synonym: "streptomycin adenylate synthetase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenyltransferase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenylylase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] +synonym: "streptomycin-spectinomycin adenylyltransferase activity" NARROW [EC:2.7.7.47] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0034069 +name: aminoglycoside N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside." [GOC:cb] +synonym: "kanamycin acetyltransferase activity" NARROW [] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0034070 +name: aminoglycoside 1-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring." [GOC:cb] +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0034071 +name: aminoglycoside phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside." [GOC:cb, GOC:mah] +synonym: "aminoglycoside kinase activity" EXACT [] +xref: EC:2.7.1.190 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0034072 +name: squalene cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = triterpene." [GOC:cb, PMID:18033581] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0034073 +name: tetrahymanol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = tetrahymanol." [GOC:cb, PMID:18033581] +is_a: GO:0034072 ! squalene cyclase activity + +[Term] +id: GO:0034074 +name: marneral synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene = marneral." [GOC:cb, http://www.wiley-vch.de/contents/jc_2002/2006/z503420_s.pdf, PMID:16425307, PMID:18033581] +xref: MetaCyc:RXN-9664 +xref: RHEA:31875 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034075 +name: arabidiol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol)." [GOC:cb, PMID:16774269, PMID:17474751] +xref: EC:4.2.1.124 +xref: MetaCyc:RXN-9684 +xref: RHEA:31035 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034076 +name: cucurbitadienol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidosqualene = cucurbitadienol." [GOC:cb, PMID:18033581] +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0034077 +name: butanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [ISBN:0911910123, MetaCyc:BUTANEDIOL, MetaCyc:P125-PWY] +synonym: "butanediol metabolism" EXACT [] +synonym: "butylene glycol metabolic process" EXACT [] +synonym: "butylene glycol metabolism" EXACT [] +is_a: GO:0042844 ! glycol metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0034078 +name: butanediol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] +synonym: "butanediol breakdown" EXACT [] +synonym: "butanediol catabolism" EXACT [] +synonym: "butanediol degradation" EXACT [] +synonym: "butanediol utilization" RELATED [] +synonym: "butylene glycol catabolic process" EXACT [] +synonym: "butylene glycol catabolism" EXACT [] +is_a: GO:0034077 ! butanediol metabolic process +is_a: GO:0042846 ! glycol catabolic process + +[Term] +id: GO:0034079 +name: butanediol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of butanediol; the biologically relevant isomer is 2,3-butanediol, CH3CH(OH)CH(OH)CH3." [GOC:mah, ISBN:0911910123, MetaCyc:125-PWY, MetaCyc:BUTANEDIOL] +synonym: "butanediol anabolism" EXACT [] +synonym: "butanediol biosynthesis" EXACT [] +synonym: "butanediol formation" EXACT [] +synonym: "butanediol synthesis" EXACT [] +synonym: "butylene glycol biosynthesis" EXACT [] +synonym: "butylene glycol biosynthetic process" EXACT [] +xref: MetaCyc:P125-PWY +is_a: GO:0034077 ! butanediol metabolic process +is_a: GO:0042845 ! glycol biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0034080 +name: CENP-A containing chromatin assembly +namespace: biological_process +alt_id: GO:0034509 +def: "The formation of chromatin containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403] +synonym: "CenH3-containing nucleosome assembly at centromere" RELATED [] +synonym: "CENP-A containing nucleosome assembly" RELATED [] +synonym: "CENP-A containing nucleosome assembly at centromere" EXACT [GOC:vw] +synonym: "CENP-A deposition" RELATED [GOC:vw] +synonym: "CENP-A loading" RELATED [GOC:vw] +synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah] +synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw] +synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah] +synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah] +is_a: GO:0006334 ! nucleosome assembly +is_a: GO:0006336 ! DNA replication-independent chromatin assembly +is_a: GO:0031055 ! chromatin remodeling at centromere +is_a: GO:0043486 ! histone exchange +relationship: part_of GO:0034508 ! centromere complex assembly +relationship: part_of GO:0061641 ! CENP-A containing chromatin organization + +[Term] +id: GO:0034081 +name: polyketide synthase complex +namespace: cellular_component +def: "A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones." [GOC:mah, PMID:12636085] +synonym: "PKS" RELATED [] +synonym: "PKS complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034082 +name: type II polyketide synthase complex +namespace: cellular_component +def: "A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction." [GOC:cb, GOC:mah, PMID:12636085] +synonym: "type II PKS" EXACT [] +synonym: "type II PKS complex" EXACT [] +synonym: "type II polyketide synthase" EXACT [] +is_a: GO:0034081 ! polyketide synthase complex + +[Term] +id: GO:0034083 +name: type III polyketide synthase complex +namespace: cellular_component +def: "A polyketide synthase complex that consists of two identical ketosynthase polypeptides." [GOC:cb, PMID:12636085] +synonym: "type III PKS" EXACT [] +synonym: "type III PKS complex" EXACT [] +synonym: "type III polyketide synthase" EXACT [] +is_a: GO:0034081 ! polyketide synthase complex + +[Term] +id: GO:0034084 +name: steryl deacetylase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol." [GOC:rb, PMID:18034159] +synonym: "sterol deacetylase activity" EXACT [] +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0034085 +name: establishment of sister chromatid cohesion +namespace: biological_process +def: "The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase." [GOC:jh, GOC:mah, PMID:14623866] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0034086 +name: maintenance of sister chromatid cohesion +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate." [GOC:mah, PMID:14623866] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0034087 +name: establishment of mitotic sister chromatid cohesion +namespace: biological_process +def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle." [GOC:mah] +is_a: GO:0034085 ! establishment of sister chromatid cohesion +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0034088 +name: maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah] +synonym: "mitotic cohesion stability" RELATED [] +is_a: GO:0034086 ! maintenance of sister chromatid cohesion +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0034089 +name: establishment of meiotic sister chromatid cohesion +namespace: biological_process +def: "The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle." [GOC:mah] +is_a: GO:0034085 ! establishment of sister chromatid cohesion +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0034090 +name: maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:mah] +is_a: GO:0034086 ! maintenance of sister chromatid cohesion +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0034091 +name: regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +relationship: regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034092 +name: negative regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:0045875 ! negative regulation of sister chromatid cohesion +relationship: negatively_regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034093 +name: positive regulation of maintenance of sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:0045876 ! positive regulation of sister chromatid cohesion +relationship: positively_regulates GO:0034086 ! maintenance of sister chromatid cohesion + +[Term] +id: GO:0034094 +name: regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034095 +name: negative regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034096 +name: positive regulation of maintenance of meiotic sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0034090 ! maintenance of meiotic sister chromatid cohesion + +[Term] +id: GO:0034097 +name: response to cytokine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:sl] +synonym: "response to cytokine stimulus" EXACT [GOC:dos] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0034098 +name: VCP-NPL4-UFD1 AAA ATPase complex +namespace: cellular_component +def: "A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry)." [PMID:11813000, PMID:16179952] +synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW [] +synonym: "p97-Ufd1-Npl4 complex" EXACT [PMID:12847084] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0034099 +name: luminal surveillance complex +namespace: cellular_component +def: "A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins." [PMID:16873065] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005788 ! endoplasmic reticulum lumen + +[Term] +id: GO:0034101 +name: erythrocyte homeostasis +namespace: biological_process +def: "Any process of regulating the production and elimination of erythrocytes within an organism." [GOC:add, PMID:10694114, PMID:14754397] +synonym: "RBC homeostasis" EXACT [CL:0000232] +synonym: "red blood cell homeostasis" EXACT [CL:0000232] +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0034102 +name: erythrocyte clearance +namespace: biological_process +def: "The selective elimination of erythrocytes from the body by autoregulatory mechanisms." [GOC:add, PMID:12905029, PMID:14754397] +comment: Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. +synonym: "neocytolysis" NARROW [PMID:14754397] +synonym: "RBC clearance" EXACT [CL:0000232] +synonym: "red blood cell clearance" EXACT [CL:0000232] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0034101 ! erythrocyte homeostasis + +[Term] +id: GO:0034103 +name: regulation of tissue remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034104 +name: negative regulation of tissue remodeling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0034103 ! regulation of tissue remodeling +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034105 +name: positive regulation of tissue remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of tissue remodeling." [GOC:add] +is_a: GO:0034103 ! regulation of tissue remodeling +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0048771 ! tissue remodeling + +[Term] +id: GO:0034106 +name: regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "regulation of neocytolysis" NARROW [PMID:14754397] +synonym: "regulation of RBC clearance" EXACT [CL:0000232] +synonym: "regulation of red blood cell clearance" EXACT [CL:0000232] +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034107 +name: negative regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "negative regulation of neocytolysis" NARROW [PMID:14754397] +synonym: "negative regulation of RBC clearance" EXACT [CL:0000232] +synonym: "negative regulation of red blood cell clearance" EXACT [CL:0000232] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0034106 ! regulation of erythrocyte clearance +relationship: negatively_regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034108 +name: positive regulation of erythrocyte clearance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance." [GOC:add, PMID:12905029, PMID:14754397] +synonym: "positive regulation of neocytolysis" NARROW [PMID:14754397] +synonym: "positive regulation of RBC clearance" EXACT [CL:0000232] +synonym: "positive regulation of red blood cell clearance" EXACT [CL:0000232] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0034106 ! regulation of erythrocyte clearance +relationship: positively_regulates GO:0034102 ! erythrocyte clearance + +[Term] +id: GO:0034109 +name: homotypic cell-cell adhesion +namespace: biological_process +def: "The attachment of a cell to a second cell of the identical type via adhesion molecules." [GOC:add] +comment: Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0034110 +name: regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034111 +name: negative regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: negatively_regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034112 +name: positive regulation of homotypic cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: positively_regulates GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034113 +name: heterotypic cell-cell adhesion +namespace: biological_process +def: "The attachment of a cell to a cell of a different type via adhesion molecules." [GOC:add] +comment: Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0034114 +name: regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034115 +name: negative regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion +is_a: GO:0070587 ! regulation of cell-cell adhesion involved in gastrulation +relationship: negatively_regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034116 +name: positive regulation of heterotypic cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion." [GOC:add] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion +relationship: positively_regulates GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0034117 +name: erythrocyte aggregation +namespace: biological_process +def: "The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules." [GOC:add, PMID:14631543] +synonym: "RBC aggregation" EXACT [CL:0000232] +synonym: "red blood cell aggregation" EXACT [CL:0000232] +is_a: GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0034118 +name: regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +synonym: "regulation of RBC aggregation" EXACT [CL:0000232] +synonym: "regulation of red blood cell aggregation" EXACT [CL:0000232] +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034119 +name: negative regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +synonym: "negative regulation of RBC aggregation" EXACT [CL:0000232] +synonym: "negative regulation of red blood cell aggregation" EXACT [CL:0000232] +is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion +is_a: GO:0034118 ! regulation of erythrocyte aggregation +relationship: negatively_regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034120 +name: positive regulation of erythrocyte aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of erythrocyte aggregation." [GOC:add] +synonym: "positive regulation of RBC aggregation" EXACT [CL:0000232] +synonym: "positive regulation of red blood cell aggregation" EXACT [CL:0000232] +is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion +is_a: GO:0034118 ! regulation of erythrocyte aggregation +relationship: positively_regulates GO:0034117 ! erythrocyte aggregation + +[Term] +id: GO:0034121 +name: regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway +relationship: regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034122 +name: negative regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034123 +name: positive regulation of toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway +relationship: positively_regulates GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034124 +name: regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation ofMyD88-dependent TLR signaling pathway" EXACT [] +synonym: "regulation ofMyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034125 +name: negative regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "negative regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034126 +name: positive regulation of MyD88-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of MyD88-dependent TLR signaling pathway" EXACT [] +synonym: "positive regulation of MyD88-dependent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034124 ! regulation of MyD88-dependent toll-like receptor signaling pathway +relationship: positively_regulates GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0034127 +name: regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation ofMyD88-independent TLR signaling pathway" EXACT [] +synonym: "regulation ofMyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034128 +name: negative regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of MyD88-independent TLR signaling pathway" EXACT [] +synonym: "negative regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway +relationship: negatively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034129 +name: positive regulation of MyD88-independent toll-like receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of MyD88-independent TLR signaling pathway" EXACT [] +synonym: "positive regulation of MyD88-independent toll-like receptor" EXACT [] +synonym: "positive regulation of MyD88-independent toll-like receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034127 ! regulation of MyD88-independent toll-like receptor signaling pathway +relationship: positively_regulates GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0034130 +name: toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 1." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR1 signaling pathway" EXACT [] +synonym: "toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034131 +name: regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR1 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034132 +name: negative regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR1 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway +relationship: negatively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034133 +name: positive regulation of toll-like receptor 1 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 1 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR1 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 1 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034131 ! regulation of toll-like receptor 1 signaling pathway +relationship: positively_regulates GO:0034130 ! toll-like receptor 1 signaling pathway + +[Term] +id: GO:0034134 +name: toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 2." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR2 signaling pathway" EXACT [] +synonym: "toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034135 +name: regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR2 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034136 +name: negative regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR2 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway +relationship: negatively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034137 +name: positive regulation of toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR2 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 2 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034135 ! regulation of toll-like receptor 2 signaling pathway +relationship: positively_regulates GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0034138 +name: toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 3." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR3 signaling pathway" EXACT [] +synonym: "toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034139 +name: regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR3 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034140 +name: negative regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR3 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway +relationship: negatively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034141 +name: positive regulation of toll-like receptor 3 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR3 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 3 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034139 ! regulation of toll-like receptor 3 signaling pathway +relationship: positively_regulates GO:0034138 ! toll-like receptor 3 signaling pathway + +[Term] +id: GO:0034142 +name: toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 4." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR4 signaling pathway" EXACT [] +synonym: "toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034143 +name: regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR4 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034144 +name: negative regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR4 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway +relationship: negatively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034145 +name: positive regulation of toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR4 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 4 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034143 ! regulation of toll-like receptor 4 signaling pathway +relationship: positively_regulates GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0034146 +name: toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 5." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR5 signaling pathway" EXACT [] +synonym: "toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034147 +name: regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR5 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034148 +name: negative regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR5 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway +relationship: negatively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034149 +name: positive regulation of toll-like receptor 5 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 5 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR5 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 5 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034147 ! regulation of toll-like receptor 5 signaling pathway +relationship: positively_regulates GO:0034146 ! toll-like receptor 5 signaling pathway + +[Term] +id: GO:0034150 +name: toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 6." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR6 signaling pathway" EXACT [] +synonym: "toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034151 +name: regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR6 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034152 +name: negative regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR6 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway +relationship: negatively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034153 +name: positive regulation of toll-like receptor 6 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 6 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR6 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 6 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034151 ! regulation of toll-like receptor 6 signaling pathway +relationship: positively_regulates GO:0034150 ! toll-like receptor 6 signaling pathway + +[Term] +id: GO:0034154 +name: toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 7." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR7 signaling pathway" EXACT [] +synonym: "toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034155 +name: regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR7 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034156 +name: negative regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR7 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway +relationship: negatively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034157 +name: positive regulation of toll-like receptor 7 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 7 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR7 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 7 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034155 ! regulation of toll-like receptor 7 signaling pathway +relationship: positively_regulates GO:0034154 ! toll-like receptor 7 signaling pathway + +[Term] +id: GO:0034158 +name: toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 8." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR8 signaling pathway" EXACT [] +synonym: "toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034159 +name: regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR8 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034160 +name: negative regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR8 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway +relationship: negatively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034161 +name: positive regulation of toll-like receptor 8 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 8 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR8 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 8 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034159 ! regulation of toll-like receptor 8 signaling pathway +relationship: positively_regulates GO:0034158 ! toll-like receptor 8 signaling pathway + +[Term] +id: GO:0034162 +name: toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 9." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR9 signaling pathway" EXACT [] +synonym: "toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034163 +name: regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR9 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034164 +name: negative regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR9 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway +relationship: negatively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034165 +name: positive regulation of toll-like receptor 9 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR9 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 9 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034163 ! regulation of toll-like receptor 9 signaling pathway +relationship: positively_regulates GO:0034162 ! toll-like receptor 9 signaling pathway + +[Term] +id: GO:0034166 +name: toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 10." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR10 signaling pathway" EXACT [] +synonym: "toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034167 +name: regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR10 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034168 +name: negative regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR10 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway +relationship: negatively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034169 +name: positive regulation of toll-like receptor 10 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 10 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR10 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 10 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034167 ! regulation of toll-like receptor 10 signaling pathway +relationship: positively_regulates GO:0034166 ! toll-like receptor 10 signaling pathway + +[Term] +id: GO:0034170 +name: toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 11." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR11 signaling pathway" EXACT [] +synonym: "toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034171 +name: regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR11 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034172 +name: negative regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR11 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway +relationship: negatively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034173 +name: positive regulation of toll-like receptor 11 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 11 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR11 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 11 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034171 ! regulation of toll-like receptor 11 signaling pathway +relationship: positively_regulates GO:0034170 ! toll-like receptor 11 signaling pathway + +[Term] +id: GO:0034174 +name: toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 12." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR12 signaling pathway" EXACT [] +synonym: "toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034175 +name: regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR12 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034176 +name: negative regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR12 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway +relationship: negatively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034177 +name: positive regulation of toll-like receptor 12 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 12 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR12 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 12 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034175 ! regulation of toll-like receptor 12 signaling pathway +relationship: positively_regulates GO:0034174 ! toll-like receptor 12 signaling pathway + +[Term] +id: GO:0034178 +name: toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 13." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "TLR13 signaling pathway" EXACT [] +synonym: "toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0034179 +name: regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "regulation of TLR13 signaling pathway" EXACT [] +synonym: "regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034180 +name: negative regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "negative regulation of TLR13 signaling pathway" EXACT [] +synonym: "negative regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway +relationship: negatively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034181 +name: positive regulation of toll-like receptor 13 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of toll-like receptor 13 signaling pathway." [GOC:add, PMID:16551253, PMID:17328678] +synonym: "positive regulation of TLR13 signaling pathway" EXACT [] +synonym: "positive regulation of toll-like receptor 13 signalling pathway" EXACT [] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:0034179 ! regulation of toll-like receptor 13 signaling pathway +relationship: positively_regulates GO:0034178 ! toll-like receptor 13 signaling pathway + +[Term] +id: GO:0034182 +name: regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034091 ! regulation of maintenance of sister chromatid cohesion +relationship: regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034183 +name: negative regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034092 ! negative regulation of maintenance of sister chromatid cohesion +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: negatively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034184 +name: positive regulation of maintenance of mitotic sister chromatid cohesion +namespace: biological_process +def: "Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a mitotic cell cycle." [GOC:mah, GOC:vw] +is_a: GO:0034093 ! positive regulation of maintenance of sister chromatid cohesion +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: positively_regulates GO:0034088 ! maintenance of mitotic sister chromatid cohesion + +[Term] +id: GO:0034185 +name: apolipoprotein binding +namespace: molecular_function +def: "Binding to an apolipoprotein, the protein component of a lipoprotein complex." [GOC:BHF, GOC:rl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0034186 +name: apolipoprotein A-I binding +namespace: molecular_function +def: "Binding to apolipoprotein A-I." [GOC:BHF, GOC:rl] +is_a: GO:0034185 ! apolipoprotein binding + +[Term] +id: GO:0034187 +name: obsolete apolipoprotein E binding +namespace: molecular_function +def: "OBSOLETE. Binding to apolipoprotein E." [GOC:BHF, GOC:rl] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "apolipoprotein E binding" EXACT [] +is_obsolete: true +replaced_by: GO:0034185 + +[Term] +id: GO:0034188 +name: apolipoprotein A-I receptor activity +namespace: molecular_function +def: "Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:BHF, GOC:rl, GOC:signaling, PMID:16443932] +is_a: GO:0004888 ! transmembrane signaling receptor activity +is_a: GO:0030226 ! apolipoprotein receptor activity + +[Term] +id: GO:0034189 +name: very-low-density lipoprotein particle binding +namespace: molecular_function +def: "Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm." [GOC:BHF, GOC:mah] +synonym: "very-low-density lipoprotein binding" EXACT [GOC:bf, GOC:dph] +synonym: "VLDL binding" EXACT [] +is_a: GO:0005515 ! protein binding +is_a: GO:0071813 ! lipoprotein particle binding + +[Term] +id: GO:0034190 +name: apolipoprotein receptor binding +namespace: molecular_function +def: "Binding to an apolipoprotein receptor." [GOC:BHF, GOC:rl] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0034191 +name: apolipoprotein A-I receptor binding +namespace: molecular_function +def: "Binding to an apolipoprotein A-I receptor." [GOC:BHF, GOC:rl] +comment: Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms. +is_a: GO:0034190 ! apolipoprotein receptor binding + +[Term] +id: GO:0034192 +name: D-galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-galactonate, the anion of D-galactonic acid." [GOC:mah] +synonym: "D-galactonate metabolism" EXACT [] +is_a: GO:0019583 ! galactonate metabolic process + +[Term] +id: GO:0034193 +name: L-galactonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-galactonate, the anion of L-galactonic acid." [GOC:mah] +synonym: "L-galactonate metabolism" EXACT [] +is_a: GO:0019583 ! galactonate metabolic process + +[Term] +id: GO:0034194 +name: D-galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid." [GOC:ai, GOC:mah] +synonym: "D-galactonate breakdown" EXACT [] +synonym: "D-galactonate catabolism" EXACT [] +synonym: "D-galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019584 ! galactonate catabolic process +is_a: GO:0034192 ! D-galactonate metabolic process + +[Term] +id: GO:0034195 +name: L-galactonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-galactonate, the anion of L-galactonic acid." [GOC:ai, GOC:mah] +synonym: "L-galactonate breakdown" EXACT [] +synonym: "L-galactonate catabolism" EXACT [] +synonym: "L-galactonate degradation" EXACT [] +xref: MetaCyc:GALACTCAT-PWY +is_a: GO:0019584 ! galactonate catabolic process +is_a: GO:0034193 ! L-galactonate metabolic process + +[Term] +id: GO:0034196 +name: acylglycerol transport +namespace: biological_process +def: "The directed movement of an acylglycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An acylglycerol is any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:BHF, GOC:rl] +synonym: "glyceride transport" EXACT [] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0034197 +name: triglyceride transport +namespace: biological_process +def: "The directed movement of triglyceride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [GOC:BHF, GOC:rl] +synonym: "triacylglycerol transport" EXACT [] +is_a: GO:0034196 ! acylglycerol transport + +[Term] +id: GO:0034198 +name: cellular response to amino acid starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [GOC:ecd] +synonym: "GAAC response" NARROW [PMID:29596413] +synonym: "general amino acid control response" NARROW [PMID:29596413] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:1990928 ! response to amino acid starvation + +[Term] +id: GO:0034199 +name: activation of protein kinase A activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme protein kinase A." [GOC:pde] +synonym: "protein kinase A activation" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:0034200 +name: D,D-heptose 1,7-bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate." [MetaCyc:RXN0-4361, PMID:11279237] +xref: MetaCyc:RXN0-4361 +xref: RHEA:28518 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0034201 +name: response to oleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:lp] +synonym: "response to oleate" EXACT [GOC:mah] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:0034202 +name: glycolipid floppase activity +namespace: molecular_function +def: "Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:krc, PMID:11807558] +synonym: "ATP-dependent intramembrane glycolipid transporter activity" BROAD [] +synonym: "ATPase-coupled intramembrane glycolipid transporter activity" BROAD [] +synonym: "glycolipid floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "glycolipid-translocating activity" BROAD [] +xref: Reactome:R-HSA-446212 "Flipping of the N-glycan precursor to inside the ER" +xref: Reactome:R-HSA-4570573 "Defective RFT1 does not flip the N-glycan precursor" +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0034203 +name: glycolipid translocation +namespace: biological_process +def: "The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:go_curators, PMID:11807558] +is_a: GO:0034204 ! lipid translocation +is_a: GO:0046836 ! glycolipid transport + +[Term] +id: GO:0034204 +name: lipid translocation +namespace: biological_process +def: "The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:mah] +synonym: "intramembrane lipid transfer" EXACT [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0097035 ! regulation of membrane lipid distribution + +[Term] +id: GO:0034205 +name: amyloid-beta formation +namespace: biological_process +def: "The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP)." [GOC:mah] +comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000). +synonym: "beta-amyloid formation" EXACT [] +synonym: "beta-amyloid polypeptide formation from amyloid precursor protein" EXACT [] +synonym: "beta-amyloid polypeptide formation from APP" EXACT [] +is_a: GO:0042987 ! amyloid precursor protein catabolic process +is_a: GO:0050435 ! amyloid-beta metabolic process + +[Term] +id: GO:0034206 +name: enhanceosome +namespace: cellular_component +def: "A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation." [PMID:11250145, PMID:17574024] +xref: Wikipedia:Enhanceosome +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0034207 +name: steroid acetylation +namespace: biological_process +def: "The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034208 +name: steroid deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:mah] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034209 +name: sterol acetylation +namespace: biological_process +def: "The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:0034207 ! steroid acetylation + +[Term] +id: GO:0034210 +name: sterol deacetylation +namespace: biological_process +def: "The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:rb, PMID:18034159] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:0034208 ! steroid deacetylation + +[Term] +id: GO:0034211 +name: GTP-dependent protein kinase activity +namespace: molecular_function +def: "GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:ecd, PMID:17200152] +comment: The reaction requires the presence of GTP. +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0034212 +name: peptide N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] +xref: Reactome:R-HSA-3371554 "HSF1 acetylation at Lys80" +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0034213 +name: quinolinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:mah] +synonym: "quinolinate breakdown" EXACT [] +synonym: "quinolinate catabolism" EXACT [] +synonym: "quinolinate degradation" EXACT [] +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:0046874 ! quinolinate metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process + +[Term] +id: GO:0034214 +name: protein hexamerization +namespace: biological_process +def: "The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits." [GOC:ecd] +synonym: "protein hexamer assembly" EXACT [] +synonym: "protein hexamer biosynthesis" EXACT [] +synonym: "protein hexamer biosynthetic process" EXACT [] +synonym: "protein hexamer formation" EXACT [] +is_a: GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0034215 +name: thiamine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in)." [GOC:mah] +synonym: "thiamin:hydrogen symporter activity" EXACT [] +synonym: "thiamin:proton symporter activity" EXACT [] +synonym: "thiamine:hydrogen symporter activity" EXACT [] +is_a: GO:0015234 ! thiamine transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0034216 +name: high-affinity thiamine:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] +synonym: "high affinity thiamin:hydrogen symporter activity" EXACT [] +synonym: "high-affinity thiamin:hydrogen symporter activity" EXACT [] +synonym: "high-affinity thiamin:proton symporter activity" EXACT [] +synonym: "high-affinity thiamine:hydrogen symporter activity" EXACT [] +is_a: GO:0034215 ! thiamine:proton symporter activity + +[Term] +id: GO:0034217 +name: ascospore wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] +synonym: "ascospore wall chitin anabolism" EXACT [] +synonym: "ascospore wall chitin biosynthesis" EXACT [] +synonym: "ascospore wall chitin formation" EXACT [] +synonym: "ascospore wall chitin synthesis" EXACT [] +is_a: GO:0034218 ! ascospore wall chitin metabolic process +is_a: GO:0034221 ! fungal-type cell wall chitin biosynthetic process +is_a: GO:0044106 ! cellular amine metabolic process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0070591 ! ascospore wall biogenesis + +[Term] +id: GO:0034218 +name: ascospore wall chitin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah, GOC:vw] +synonym: "ascospore wall chitin metabolism" EXACT [] +is_a: GO:0006037 ! cell wall chitin metabolic process +is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process + +[Term] +id: GO:0034219 +name: carbohydrate transmembrane transport +namespace: biological_process +def: "The process in which a carbohydrate is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "carbohydrate membrane transport" EXACT [] +synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034220 +name: ion transmembrane transport +namespace: biological_process +alt_id: GO:0099131 +def: "A process in which an ion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ATP hydrolysis coupled ion transmembrane transport" NARROW [] +synonym: "ion membrane transport" EXACT [] +synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006811 ! ion transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034221 +name: fungal-type cell wall chitin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells." [GOC:mah] +synonym: "fungal-type cell wall chitin anabolism" EXACT [] +synonym: "fungal-type cell wall chitin biosynthesis" EXACT [] +synonym: "fungal-type cell wall chitin formation" EXACT [] +synonym: "fungal-type cell wall chitin synthesis" EXACT [] +is_a: GO:0006038 ! cell wall chitin biosynthetic process +relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0034222 +name: regulation of cell wall chitin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall." [GOC:mah] +synonym: "regulation of cell wall chitin metabolism" EXACT [] +is_a: GO:0032882 ! regulation of chitin metabolic process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006037 ! cell wall chitin metabolic process + +[Term] +id: GO:0034223 +name: regulation of ascospore wall chitin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin." [GOC:mah] +synonym: "regulation of ascospore wall chitin anabolism" EXACT [] +synonym: "regulation of ascospore wall chitin biosynthesis" EXACT [] +synonym: "regulation of ascospore wall chitin formation" EXACT [] +synonym: "regulation of ascospore wall chitin synthesis" EXACT [] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0032884 ! regulation of cell wall chitin biosynthetic process +is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0034217 ! ascospore wall chitin biosynthetic process + +[Term] +id: GO:0034224 +name: cellular response to zinc ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah] +synonym: "cellular response to zinc ion limitation" EXACT [] +synonym: "cellular response to zinc starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0120127 ! response to zinc ion starvation + +[Term] +id: GO:0034225 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation +namespace: biological_process +def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of zinc ions." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc deficiency" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter in response to zinc ion limitation" EXACT [] +is_obsolete: true +consider: GO:0006357 +consider: GO:0034224 + +[Term] +id: GO:0034227 +name: tRNA thio-modification +namespace: biological_process +def: "The addition a sulfur atom to a nucleotide in a tRNA molecule." [GOC:mcc, PMID:12549933, PMID:14722066] +synonym: "tRNA thiolation" EXACT [PMID:24774365] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0034228 +name: ethanolamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] +synonym: "2-aminoethanol transmembrane transporter activity" EXACT [] +synonym: "ethanolamine permease activity" EXACT [] +synonym: "monoethanolamine transmembrane transporter activity" EXACT [] +xref: RHEA:32747 +is_a: GO:0005275 ! amine transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0034229 +name: ethanolamine transport +namespace: biological_process +def: "The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine." [GOC:rn, PMID:3514579] +synonym: "2-aminoethanol transport" EXACT [] +synonym: "monoethanolamine transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015837 ! amine transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0034230 +name: enkephalin processing +namespace: biological_process +def: "The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide." [GOC:BHF, GOC:mah, GOC:rl, PMID:8262946] +synonym: "enkephalin formation" EXACT [] +synonym: "peptide enkephalin formation" EXACT [] +synonym: "peptide enkephalin processing" EXACT [] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0034231 +name: islet amyloid polypeptide processing +namespace: biological_process +def: "The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP)." [GOC:BHF, GOC:rl, PMID:15983213, PMID:8262946] +synonym: "IAPP formation" EXACT [] +synonym: "IAPP processing" EXACT [] +synonym: "islet amyloid peptide formation" EXACT [] +synonym: "islet amyloid peptide processing" EXACT [] +synonym: "islet amyloid polypeptide formation" RELATED [] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0034232 +name: ascospore wall chitin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall chitin breakdown" EXACT [] +synonym: "ascospore wall chitin catabolism" EXACT [] +synonym: "ascospore wall chitin degradation" EXACT [] +is_a: GO:0006039 ! cell wall chitin catabolic process +is_a: GO:0034218 ! ascospore wall chitin metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0044347 ! cell wall polysaccharide catabolic process +is_a: GO:0071854 ! cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly + +[Term] +id: GO:0034233 +name: regulation of cell wall chitin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin." [GOC:mah] +synonym: "regulation of cell wall chitin breakdown" EXACT [] +synonym: "regulation of cell wall chitin catabolism" EXACT [] +synonym: "regulation of cell wall chitin degradation" EXACT [] +is_a: GO:0034222 ! regulation of cell wall chitin metabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +relationship: regulates GO:0006039 ! cell wall chitin catabolic process + +[Term] +id: GO:0034234 +name: regulation of ascospore wall chitin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of ascospore wall chitin." [GOC:mah] +synonym: "regulation of ascospore wall chitin breakdown" EXACT [] +synonym: "regulation of ascospore wall chitin catabolism" EXACT [] +synonym: "regulation of ascospore wall chitin degradation" EXACT [] +is_a: GO:0034233 ! regulation of cell wall chitin catabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: regulates GO:0034232 ! ascospore wall chitin catabolic process + +[Term] +id: GO:0034235 +name: GPI anchor binding +namespace: molecular_function +def: "Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] +comment: Note that this term should be used to annotate gene products that interact non-covalently with GPI anchors, and not proteins that have GPI anchors covalently attached. +synonym: "glycosylphosphatidylinositol binding" EXACT [] +is_a: GO:0035091 ! phosphatidylinositol binding +is_a: GO:0051861 ! glycolipid binding + +[Term] +id: GO:0034236 +name: protein kinase A catalytic subunit binding +namespace: molecular_function +def: "Binding to one or both of the catalytic subunits of protein kinase A." [GOC:mah] +synonym: "PKA catalytic subunit binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding +is_a: GO:0051018 ! protein kinase A binding + +[Term] +id: GO:0034237 +name: protein kinase A regulatory subunit binding +namespace: molecular_function +def: "Binding to one or both of the regulatory subunits of protein kinase A." [GOC:mah] +synonym: "PKA regulatory subunit binding" EXACT [] +synonym: "protein kinase A anchoring activity" RELATED [] +is_a: GO:0051018 ! protein kinase A binding + +[Term] +id: GO:0034238 +name: macrophage fusion +namespace: biological_process +def: "The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell." [GOC:sl] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0034239 +name: regulation of macrophage fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034240 +name: negative regulation of macrophage fusion +namespace: biological_process +def: "Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0034239 ! regulation of macrophage fusion +is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion +relationship: negatively_regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034241 +name: positive regulation of macrophage fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage fusion." [GOC:mah] +is_a: GO:0034239 ! regulation of macrophage fusion +is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion +relationship: positively_regulates GO:0034238 ! macrophage fusion + +[Term] +id: GO:0034242 +name: negative regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mah] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: negatively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0034243 +name: regulation of transcription elongation from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:0090039 +def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] +synonym: "regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] +synonym: "regulation of RNA elongation from RNA polymerase II promoter" EXACT [] +is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation +relationship: regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:0034244 +name: negative regulation of transcription elongation from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:0090041 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] +synonym: "negative regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] +synonym: "negative regulation of RNA elongation from RNA polymerase II promoter" EXACT [] +is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation +is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter +relationship: negatively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:0034245 +name: mitochondrial DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form." [GOC:krc, GOC:mah, PMID:7929382] +synonym: "mitochondrial RNA polymerase complex" BROAD [] +synonym: "mitochondrial RNA polymerase holoenzyme complex" EXACT [] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0034246 +name: mitochondrial transcription factor activity +namespace: molecular_function +alt_id: GO:0000998 +alt_id: GO:0001142 +alt_id: GO:0001143 +alt_id: GO:0001144 +def: "Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase." [GOC:txnOH-2018, PMID:18391175] +synonym: "mitochondrial DNA-binding transcription factor activity" NARROW [] +synonym: "mitochondrial polymerase transcription factor activity" EXACT [] +synonym: "mitochondrial RNA polymerase binding promoter specificity activity" EXACT [] +synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "mitochondrial RNA polymerase promoter specificity activity" RELATED [] +synonym: "mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding" EXACT [] +synonym: "mitochondrial sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "mitochondrial sequence-specific DNA-binding transcription factor activity" NARROW [] +synonym: "mitochondrial transcription initiation factor activity" EXACT [] +synonym: "sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity" EXACT [] +synonym: "transcription factor activity, mitochondrial proximal promoter sequence-specific binding" EXACT [] +synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding" EXACT [] +synonym: "transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding" EXACT [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0034247 +name: snoRNA splicing +namespace: biological_process +def: "The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." [GOC:mah] +is_a: GO:0008380 ! RNA splicing +is_a: GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:0034248 +name: regulation of cellular amide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "regulation of amide metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034249 +name: negative regulation of cellular amide metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "negative regulation of amide metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034250 +name: positive regulation of cellular amide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] +synonym: "positive regulation of amide metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0034251 +name: regulation of cellular amide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "regulation of amide breakdown" EXACT [] +synonym: "regulation of amide catabolism" EXACT [] +synonym: "regulation of amide degradation" EXACT [] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +relationship: regulates GO:0043605 ! cellular amide catabolic process + +[Term] +id: GO:0034252 +name: negative regulation of cellular amide catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "negative regulation of amide breakdown" EXACT [] +synonym: "negative regulation of amide catabolism" EXACT [] +synonym: "negative regulation of amide degradation" RELATED [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0034251 ! regulation of cellular amide catabolic process +relationship: negatively_regulates GO:0043605 ! cellular amide catabolic process + +[Term] +id: GO:0034253 +name: positive regulation of cellular amide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides." [GOC:mah] +synonym: "positive regulation of amide breakdown" EXACT [] +synonym: "positive regulation of amide catabolism" EXACT [] +synonym: "positive regulation of amide degradation" RELATED [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0034251 ! regulation of cellular amide catabolic process +relationship: positively_regulates GO:0043605 ! cellular amide catabolic process + +[Term] +id: GO:0034254 +name: regulation of urea catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of urea." [GOC:mah] +synonym: "regulation of urea breakdown" EXACT [] +synonym: "regulation of urea catabolism" EXACT [] +synonym: "regulation of urea degradation" EXACT [] +is_a: GO:0034251 ! regulation of cellular amide catabolic process +is_a: GO:0034255 ! regulation of urea metabolic process +relationship: regulates GO:0043419 ! urea catabolic process + +[Term] +id: GO:0034255 +name: regulation of urea metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving urea." [GOC:mah] +synonym: "regulation of urea metabolism" EXACT [] +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process +relationship: regulates GO:0019627 ! urea metabolic process + +[Term] +id: GO:0034256 +name: chlorophyll(ide) b reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+." [EC:1.1.1.294, MetaCyc:RXN-7678] +synonym: "Chl b reductase activity" EXACT [] +synonym: "chlorophyll b reductase activity" EXACT [] +synonym: "chlorophyllide b reductase activity" EXACT [] +xref: EC:1.1.1.294 +xref: MetaCyc:RXN-7678 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034257 +name: nicotinamide riboside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other." [GOC:se] +xref: RHEA:33163 +is_a: GO:0005337 ! nucleoside transmembrane transporter activity + +[Term] +id: GO:0034258 +name: nicotinamide riboside transport +namespace: biological_process +def: "The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:se] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0034260 +name: negative regulation of GTPase activity +namespace: biological_process +alt_id: GO:0034259 +alt_id: GO:0034261 +alt_id: GO:1902264 +alt_id: GO:1902881 +def: "Any process that stops or reduces the rate of GTP hydrolysis by a GTPase." [GO_REF:0000058, GOC:mah, GOC:rb, GOC:TermGenie, PMID:16143306, PMID:24335649] +comment: An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649. +synonym: "down regulation of GTPase activity" EXACT [] +synonym: "down regulation of Rab GTPase activity" NARROW [GOC:pf] +synonym: "down regulation of Ras GTPase activity" NARROW [] +synonym: "down regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of Rho GTPase activity" NARROW [] +synonym: "down-regulation of GTPase activity" EXACT [] +synonym: "down-regulation of Rab GTPase activity" NARROW [GOC:pf] +synonym: "down-regulation of Ras GTPase activity" NARROW [] +synonym: "down-regulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of Rho GTPase activity" NARROW [] +synonym: "downregulation of GTPase activity" EXACT [] +synonym: "downregulation of Rab GTPase activity" NARROW [GOC:pf] +synonym: "downregulation of Ras GTPase activity" NARROW [] +synonym: "downregulation of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of Rho GTPase activity" NARROW [] +synonym: "inhibition of GTPase activity" NARROW [] +synonym: "inhibition of Rab GTPase activity" NARROW [GOC:pf] +synonym: "inhibition of Ras GTPase activity" NARROW [] +synonym: "inhibition of regulation of Ran GTPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Rho GTPase activity" NARROW [] +synonym: "negative regulation of guanosinetriphosphatase activity" EXACT [] +synonym: "negative regulation of Rab GTPase activity" NARROW [] +synonym: "negative regulation of Ran GTPase activity" NARROW [] +synonym: "negative regulation of Ras GTPase activity" NARROW [] +synonym: "negative regulation of Rho GTPase activity" NARROW [] +is_a: GO:0043087 ! regulation of GTPase activity +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0034263 +name: positive regulation of autophagy in response to ER overload +namespace: biological_process +def: "The process in which the accumulation of misfolded proteins in the endoplasmic reticulum triggers a response that positively regulates autophagy." [GOC:mah] +synonym: "autophagy in response to endoplasmic reticulum overload" EXACT [] +synonym: "autophagy in response to ER stress" EXACT [] +is_a: GO:0006983 ! ER overload response +is_a: GO:0010508 ! positive regulation of autophagy + +[Term] +id: GO:0034264 +name: isopentenyl adenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +synonym: "isopentenyl adenine metabolism" EXACT [] +synonym: "isopentenyladenine metabolic process" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0034265 +name: isopentenyl adenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +synonym: "isopentenyl adenine anabolism" EXACT [] +synonym: "isopentenyl adenine biosynthesis" EXACT [] +synonym: "isopentenyl adenine formation" EXACT [] +synonym: "isopentenyl adenine synthesis" EXACT [] +synonym: "isopentenyladenine biosynthetic process" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0034264 ! isopentenyl adenine metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0034266 +name: isopentenyl adenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine." [GOC:mah, PMID:18216168] +synonym: "isopentenyl adenine breakdown" EXACT [] +synonym: "isopentenyl adenine catabolism" EXACT [] +synonym: "isopentenyl adenine degradation" EXACT [] +synonym: "isopentenyladenine catabolic process" EXACT [] +is_a: GO:0009823 ! cytokinin catabolic process +is_a: GO:0034264 ! isopentenyl adenine metabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process + +[Term] +id: GO:0034267 +name: discadenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] +synonym: "discadenine metabolism" EXACT [] +is_a: GO:0009690 ! cytokinin metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0034268 +name: discadenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] +synonym: "discadenine anabolism" EXACT [] +synonym: "discadenine biosynthesis" EXACT [] +synonym: "discadenine formation" EXACT [] +synonym: "discadenine synthesis" EXACT [] +is_a: GO:0009691 ! cytokinin biosynthetic process +is_a: GO:0034267 ! discadenine metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0034269 +name: discadenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid." [GOC:mah] +synonym: "discadenine breakdown" EXACT [] +synonym: "discadenine catabolism" EXACT [] +synonym: "discadenine degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009823 ! cytokinin catabolic process +is_a: GO:0034267 ! discadenine metabolic process +is_a: GO:0072523 ! purine-containing compound catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0034270 +name: Cvt complex +namespace: cellular_component +def: "A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p." [GOC:rb, PMID:15659643] +synonym: "cytoplasm to vacuole targeting complex" EXACT [] +synonym: "cytoplasm-to-vacuole targeting complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034271 +name: phosphatidylinositol 3-kinase complex, class III, type I +namespace: cellular_component +def: "A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251] +comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. +synonym: "autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex" EXACT [] +synonym: "phosphatidylinositol 3-kinase complex I" RELATED [] +synonym: "PtdIns-3-kinase complex I" RELATED [] +is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III + +[Term] +id: GO:0034272 +name: phosphatidylinositol 3-kinase complex, class III, type II +namespace: cellular_component +def: "A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p." [GOC:ha, GOC:rb, PMID:11157979, PMID:16421251] +comment: Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. +synonym: "phosphatidylinositol 3-kinase complex II" RELATED [] +synonym: "PtdIns-3-kinase complex II" RELATED [] +is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III + +[Term] +id: GO:0034274 +name: Atg12-Atg5-Atg16 complex +namespace: cellular_component +def: "A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p." [GOC:rb, PMID:17986448] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034275 +name: kynurenic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah] +synonym: "4-hydroxyquinoline-2-carboxylic acid metabolic process" EXACT [] +synonym: "kynurenic acid metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0034276 +name: kynurenic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of kynurenic acid, 4-hydroxyquinoline-2-carboxylic acid." [GOC:mah] +synonym: "4-hydroxyquinoline-2-carboxylic acid biosynthetic process" EXACT [] +synonym: "kynurenic acid anabolism" EXACT [] +synonym: "kynurenic acid biosynthesis" EXACT [] +synonym: "kynurenic acid formation" RELATED [] +synonym: "kynurenic acid synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0034275 ! kynurenic acid metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0034277 +name: ent-cassa-12,15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate." [EC:4.2.3.28, RHEA:25532] +synonym: "ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity" EXACT systematic_synonym [EC:4.2.3.28, KEGG_REACTION:R09119] +xref: EC:4.2.3.28 +xref: KEGG_REACTION:R09119 +xref: MetaCyc:RXN-4881 +xref: RHEA:25532 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034278 +name: stemar-13-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." [RHEA:25552] +synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09115] +xref: EC:4.2.3.33 +xref: KEGG_REACTION:R09115 +xref: MetaCyc:RXN-4882 +xref: RHEA:25552 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034279 +name: syn-pimara-7,15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate." [RHEA:25560] +synonym: "9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity" EXACT systematic_synonym [KEGG_REACTION:R09117] +xref: EC:4.2.3.35 +xref: KEGG_REACTION:R09117 +xref: MetaCyc:RXN-4883 +xref: RHEA:25560 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034280 +name: ent-sandaracopimaradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate." [RHEA:25536] +synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09120] +synonym: "ent-pimaradiene synthase activity" BROAD [] +xref: EC:4.2.3.29 +xref: KEGG_REACTION:R09120 +xref: MetaCyc:RXN-4884 +xref: RHEA:25536 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034281 +name: ent-isokaurene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate." [PMID:17141283] +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0034282 +name: ent-pimara-8(14),15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate." [RHEA:25540] +synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09121] +synonym: "ent-pimaradiene synthase activity" BROAD [] +xref: EC:4.2.3.30 +xref: KEGG_REACTION:R09121 +xref: MetaCyc:RXN-7788 +xref: RHEA:25540 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034283 +name: syn-stemod-13(17)-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate." [RHEA:25556] +synonym: "9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity" EXACT systematic_synonym [KEGG_REACTION:R09116] +synonym: "exo-stemodene synthase activity" EXACT [] +synonym: "stemod-13(17)-ene synthase activity" EXACT [] +synonym: "stemodene synthase activity" EXACT [] +synonym: "syn-stemodene synthase activity" EXACT [] +xref: EC:4.2.3.34 +xref: KEGG_REACTION:R09116 +xref: MetaCyc:RXN-9291 +xref: RHEA:25556 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034284 +name: response to monosaccharide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] +synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0034285 +name: response to disaccharide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:sart] +synonym: "response to disaccharide stimulus" EXACT [GOC:dos] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0034286 +name: response to maltose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:sart] +synonym: "response to maltose stimulus" EXACT [GOC:dos] +is_a: GO:0034285 ! response to disaccharide + +[Term] +id: GO:0034287 +name: detection of monosaccharide stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal." [GOC:mah] +synonym: "perception of monosaccharide stimulus" RELATED [] +is_a: GO:0009730 ! detection of carbohydrate stimulus +is_a: GO:0034284 ! response to monosaccharide + +[Term] +id: GO:0034288 +name: detection of disaccharide stimulus +namespace: biological_process +def: "The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal." [GOC:sart] +synonym: "perception of disaccharide stimulus" RELATED [] +is_a: GO:0009730 ! detection of carbohydrate stimulus +is_a: GO:0034285 ! response to disaccharide + +[Term] +id: GO:0034289 +name: detection of maltose stimulus +namespace: biological_process +def: "The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal." [GOC:sart] +synonym: "perception of maltose stimulus" RELATED [] +is_a: GO:0034286 ! response to maltose +is_a: GO:0034288 ! detection of disaccharide stimulus + +[Term] +id: GO:0034290 +name: holin activity +namespace: molecular_function +def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate." [GOC:jh2, PMID:1406491, PMID:25157079] +is_a: GO:0015267 ! channel activity + +[Term] +id: GO:0034291 +name: canonical holin activity +namespace: molecular_function +def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079] +is_a: GO:0034290 ! holin activity + +[Term] +id: GO:0034292 +name: pinholin activity +namespace: molecular_function +def: "A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting ion channel activity indirectly allows endolysin (murein hydrolyases) to access their cell wall substrate by collapsing the proton motive force (PMF) across the membrane, allowing the endolysin to fold to an active form and hydrolyze bonds in the peptidoglycan cell wall." [GOC:jh2, GOC:mah, PMID:1406491, PMID:25157079] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0034290 ! holin activity + +[Term] +id: GO:0034293 +name: sexual sporulation +namespace: biological_process +def: "The formation of spores derived from the products of meiosis." [GOC:mah] +subset: goslim_aspergillus +synonym: "meiotic spore formation" EXACT [] +synonym: "meiotic sporulation" EXACT [] +synonym: "sexual spore formation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0043934 ! sporulation +relationship: part_of GO:0019953 ! sexual reproduction +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0034294 +name: sexual spore wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:mah] +synonym: "sexual spore wall formation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0042244 ! spore wall assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0034293 ! sexual sporulation + +[Term] +id: GO:0034295 +name: basidiospore formation +namespace: biological_process +def: "The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." [GOC:di, GOC:ds, GOC:mah, GOC:mcc, http://www.gsbs.utmb.edu/microbook/ch073.htm, http://www.ilmyco.gen.chicago.il.us/Terms/basid133.html] +comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034296 +name: zygospore formation +namespace: biological_process +def: "The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away." [GOC:ds, GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/zygos581.html] +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034297 +name: oidium formation +namespace: biological_process +def: "The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus." [GOC:mah, http://www.ilmyco.gen.chicago.il.us/Terms/oidiu163.html] +is_a: GO:0030436 ! asexual sporulation + +[Term] +id: GO:0034298 +name: arthrospore formation +namespace: biological_process +def: "The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation." [GOC:mah] +synonym: "arthroconidium formation" EXACT [] +is_a: GO:0048315 ! conidium formation +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0034299 +name: reproductive blastospore formation +namespace: biological_process +def: "The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota." [GOC:mah, https://en.wikipedia.org/wiki/Blastospore] +comment: Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species. +synonym: "blastoconidium formation" EXACT [] +is_a: GO:0048315 ! conidium formation +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0034300 +name: sporangiospore formation +namespace: biological_process +def: "The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:ds, GOC:mah, http://bugs.bio.usyd.edu.au/Mycology/Glossary/glossary_n_z.shtml] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034301 +name: endospore formation +namespace: biological_process +def: "The process in which a cell gives rise to an endospore, a dormant, highly resistant spore with a thick wall that forms within the mother cell. Endospores are produced by some low G+C Gram-positive bacteria in response to harsh conditions." [GOC:ds, GOC:mah, ISBN:0470090278] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034302 +name: akinete formation +namespace: biological_process +def: "The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria." [GOC:ds, GOC:mah, http://www.msu.edu/course/bot/423/algalglossary.htm#Reproductive, PMID:11948167] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034303 +name: myxospore formation +namespace: biological_process +def: "The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria." [GOC:ds, ISBN:0122268008] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034304 +name: actinomycete-type spore formation +namespace: biological_process +def: "The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales." [GOC:ds, ISBN:0122268008] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022413 ! reproductive process in single-celled organism +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0034305 +name: regulation of asexual sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation from the products of mitosis." [GOC:mah] +synonym: "regulation of asexual spore formation" EXACT [] +synonym: "regulation of mitotic spore formation" EXACT [] +synonym: "regulation of mitotic sporulation" EXACT [] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:1903664 ! regulation of asexual reproduction +relationship: regulates GO:0030436 ! asexual sporulation + +[Term] +id: GO:0034306 +name: regulation of sexual sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae." [GOC:mah] +synonym: "MAPKKK cascade during sporulation" RELATED [] +synonym: "regulation of meiotic spore formation" EXACT [] +synonym: "regulation of meiotic sporulation" EXACT [] +synonym: "regulation of sexual spore formation" EXACT [] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: regulates GO:0034293 ! sexual sporulation + +[Term] +id: GO:0034307 +name: regulation of ascospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ascospore formation. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] +synonym: "MAPKKK cascade during sporulation" RELATED [] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0034308 +name: primary alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] +synonym: "monohydric alcohol metabolic process" EXACT [] +synonym: "primary alcohol metabolism" EXACT [GOC:mah] +is_a: GO:0006066 ! alcohol metabolic process + +[Term] +id: GO:0034309 +name: primary alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] +synonym: "monohydric alcohol biosynthetic process" EXACT [] +synonym: "primary alcohol anabolism" EXACT [GOC:mah] +synonym: "primary alcohol biosynthesis" EXACT [GOC:mah] +synonym: "primary alcohol formation" EXACT [GOC:mah] +synonym: "primary alcohol synthesis" EXACT [GOC:mah] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0034310 +name: primary alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of primary alcohols. A primary alcohol is any alcohol in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [GOC:mah] +synonym: "monohydric alcohol catabolic process" EXACT [] +synonym: "primary alcohol breakdown" EXACT [GOC:mah] +synonym: "primary alcohol catabolism" EXACT [GOC:mah] +synonym: "primary alcohol degradation" EXACT [GOC:mah] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0034311 +name: diol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic." [GOC:curators] +synonym: "dihydric alcohol metabolic process" RELATED [] +synonym: "diol metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:0034312 +name: diol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah] +synonym: "dihydric alcohol biosynthetic process" EXACT [] +synonym: "diol anabolism" EXACT [] +synonym: "diol biosynthesis" EXACT [] +synonym: "diol formation" EXACT [] +synonym: "diol synthesis" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046173 ! polyol biosynthetic process + +[Term] +id: GO:0034313 +name: diol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms." [GOC:mah] +synonym: "dihydric alcohol catabolic process" EXACT [] +synonym: "diol breakdown" EXACT [] +synonym: "diol catabolism" EXACT [] +synonym: "diol degradation" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0046174 ! polyol catabolic process + +[Term] +id: GO:0034314 +name: Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins." [GOC:mah, PMID:16959963, PMID:18640983] +synonym: "actin filament branch nucleation" EXACT [] +synonym: "branched actin filament nucleation" EXACT [] +is_a: GO:0045010 ! actin nucleation + +[Term] +id: GO:0034315 +name: regulation of Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah] +is_a: GO:0051125 ! regulation of actin nucleation +relationship: regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation + +[Term] +id: GO:0034316 +name: negative regulation of Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins." [GOC:mah, PMID:16959963] +is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation +is_a: GO:0051126 ! negative regulation of actin nucleation +relationship: negatively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation + +[Term] +id: GO:0034317 +name: nicotinic acid riboside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide." [PMID:17914902] +xref: MetaCyc:RXN-8443 +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0034318 +name: alcohol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule." [GOC:mah] +synonym: "acyl-CoA:alcohol O-acyltransferase activity" EXACT [] +synonym: "acyl-CoA:ethanol O-acyltransferase" NARROW [] +synonym: "acyl-coenzymeA:alcohol O-acyltransferase activity" EXACT [] +synonym: "acyl-coenzymeA:ethanol O-acyltransferase activity" NARROW [] +synonym: "AEATase activity" NARROW [] +synonym: "alcohol acyltransferase activity" EXACT [] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0034319 +name: alcohol O-butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034323 ! O-butanoyltransferase activity + +[Term] +id: GO:0034320 +name: alcohol O-hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034324 ! O-hexanoyltransferase activity + +[Term] +id: GO:0034321 +name: alcohol O-octanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0016414 ! O-octanoyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity + +[Term] +id: GO:0034322 +name: alcohol O-decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester." [GOC:mah, PMID:16361250] +is_a: GO:0016413 ! O-acetyltransferase activity +is_a: GO:0034318 ! alcohol O-acyltransferase activity +is_a: GO:0034325 ! O-decanoyltransferase activity + +[Term] +id: GO:0034323 +name: O-butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034326 ! butanoyltransferase activity + +[Term] +id: GO:0034324 +name: O-hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034327 ! hexanoyltransferase activity + +[Term] +id: GO:0034325 +name: O-decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule." [GOC:mah] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0034328 ! decanoyltransferase activity + +[Term] +id: GO:0034326 +name: butanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034327 +name: hexanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034328 +name: decanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule." [GOC:mah] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034329 +name: cell junction assembly +namespace: biological_process +def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0034330 +name: cell junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] +subset: goslim_chembl +subset: goslim_generic +synonym: "cell junction assembly and maintenance" EXACT [] +synonym: "cell junction biogenesis" RELATED [] +synonym: "cell junction organisation" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0034331 +name: cell junction maintenance +namespace: biological_process +def: "The organization process that preserves a cell junction in a stable functional or structural state. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0034330 ! cell junction organization +is_a: GO:0043954 ! cellular component maintenance + +[Term] +id: GO:0034332 +name: adherens junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:dph, GOC:jl, GOC:mah] +synonym: "adherens junction organisation" EXACT [] +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0034333 +name: adherens junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah] +synonym: "adherens junction formation" EXACT [] +is_a: GO:0007043 ! cell-cell junction assembly +is_a: GO:0034332 ! adherens junction organization + +[Term] +id: GO:0034334 +name: adherens junction maintenance +namespace: biological_process +def: "The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, GOC:mah] +is_a: GO:0034332 ! adherens junction organization +is_a: GO:0045217 ! cell-cell junction maintenance + +[Term] +id: GO:0034335 +name: DNA negative supercoiling activity +namespace: molecular_function +def: "Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria." [GOC:bhm, GOC:krc, GOC:mah, WikiPedia:DNA_gyrase] +comment: Note that this term was reinstated from obsolete. +synonym: "DNA gyrase activity" RELATED [] +synonym: "DNA-gyrase activity" RELATED [] +is_a: GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + +[Term] +id: GO:0034336 +name: misfolded RNA binding +namespace: molecular_function +def: "Binding to an RNA molecule that has assumed an incorrect conformation." [GOC:mah, PMID:10393192] +synonym: "RNA chaperone" RELATED [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0034337 +name: RNA folding +namespace: biological_process +def: "The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure." [GOC:mah, PMID:10393192] +synonym: "RNA chaperone" RELATED [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0034338 +name: short-chain carboxylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms." [GOC:jp] +synonym: "butyrate esterase activity" NARROW [] +synonym: "butyryl esterase activity" NARROW [] +synonym: "methylbutyrase activity" NARROW [] +synonym: "methylbutyrate esterase activity" NARROW [] +synonym: "monobutyrase activity" NARROW [] +synonym: "propionyl esterase activity" NARROW [] +synonym: "short-chain esterase activity" BROAD [] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0034339 +name: obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor +namespace: biological_process +def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to modulate the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GO_REF:0000021, GOC:mah, GOC:mh] +comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand. +synonym: "regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] +is_obsolete: true +consider: GO:0004879 +consider: GO:0006357 +consider: GO:0030374 +consider: GO:0030522 + +[Term] +id: GO:0034340 +name: response to type I interferon +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] +synonym: "response to type I IFN" EXACT [] +is_a: GO:0034097 ! response to cytokine +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034341 +name: response to interferon-gamma +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon." [GOC:add, ISBN:0126896631, PMID:15546383] +synonym: "response to gamma-interferon" RELATED [] +synonym: "response to immune interferon" EXACT [] +synonym: "response to type II IFN" BROAD [] +synonym: "response to type II interferon" BROAD [] +is_a: GO:0034097 ! response to cytokine +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034342 +name: response to type III interferon +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +synonym: "response to interferon-lambda" NARROW [] +synonym: "response to type III IFN" EXACT [] +is_a: GO:0034097 ! response to cytokine +relationship: part_of GO:0045087 ! innate immune response + +[Term] +id: GO:0034343 +name: type III interferon production +namespace: biological_process +alt_id: GO:0072644 +def: "The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. This term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +synonym: "type III IFN production" EXACT [] +synonym: "type III interferon secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0034344 +name: regulation of type III interferon production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "regulation of type III IFN production" EXACT [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034345 +name: negative regulation of type III interferon production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "down regulation of type III interferon production" EXACT [] +synonym: "down-regulation of type III interferon production" EXACT [] +synonym: "downregulation of type III interferon production" EXACT [] +synonym: "inhibition of type III interferon production" NARROW [] +synonym: "negative regulation of type III IFN production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0034344 ! regulation of type III interferon production +relationship: negatively_regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034346 +name: positive regulation of type III interferon production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of type III interferon production. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "activation of type III interferon production" NARROW [] +synonym: "positive regulation of type III IFN production" EXACT [] +synonym: "stimulation of type III interferon production" NARROW [] +synonym: "up regulation of type III interferon production" EXACT [] +synonym: "up-regulation of type III interferon production" EXACT [] +synonym: "upregulation of type III interferon production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0034344 ! regulation of type III interferon production +relationship: positively_regulates GO:0034343 ! type III interferon production + +[Term] +id: GO:0034347 +name: type III interferon binding +namespace: molecular_function +def: "Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "interferon-lambda binding" NARROW [] +is_a: GO:0019961 ! interferon binding + +[Term] +id: GO:0034348 +name: type III interferon receptor activity +namespace: molecular_function +def: "Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16734557] +comment: Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. +synonym: "interferon-lambda receptor activity" NARROW [PR:000001362] +is_a: GO:0004904 ! interferon receptor activity + +[Term] +id: GO:0034349 +name: glial cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system." [CL:0000125, GOC:mtg_apoptosis, GOC:sart] +synonym: "apoptosis of glia" EXACT [] +synonym: "apoptosis of glial cells" EXACT [] +synonym: "glia apoptosis" EXACT [] +synonym: "glia programmed cell death by apoptosis" EXACT [] +synonym: "glial cell apoptosis" NARROW [] +synonym: "glial cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of glia by apoptosis" EXACT [] +synonym: "programmed cell death of glial cells by apoptosis" EXACT [] +synonym: "programmed cell death, glia" EXACT [] +synonym: "programmed cell death, glial cells" EXACT [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0034350 +name: regulation of glial cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] +synonym: "regulation of glial cell apoptosis" RELATED [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0034349 ! glial cell apoptotic process + +[Term] +id: GO:0034351 +name: negative regulation of glial cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] +synonym: "down regulation of glial cell apoptosis" EXACT [] +synonym: "down-regulation of glial cell apoptosis" EXACT [] +synonym: "downregulation of glial cell apoptosis" EXACT [] +synonym: "inhibition of glial cell apoptosis" NARROW [] +synonym: "negative regulation of glial cell apoptosis" NARROW [] +is_a: GO:0034350 ! regulation of glial cell apoptotic process +is_a: GO:0043066 ! negative regulation of apoptotic process +relationship: negatively_regulates GO:0034349 ! glial cell apoptotic process + +[Term] +id: GO:0034352 +name: positive regulation of glial cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] +synonym: "activation of glial cell apoptosis" NARROW [] +synonym: "positive regulation of glial cell apoptosis" NARROW [] +synonym: "stimulation of glial cell apoptosis" NARROW [] +synonym: "up regulation of glial cell apoptosis" EXACT [] +synonym: "up-regulation of glial cell apoptosis" EXACT [] +synonym: "upregulation of glial cell apoptosis" EXACT [] +is_a: GO:0034350 ! regulation of glial cell apoptotic process +is_a: GO:0043065 ! positive regulation of apoptotic process +relationship: positively_regulates GO:0034349 ! glial cell apoptotic process + +[Term] +id: GO:0034353 +name: RNA pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] +is_a: GO:0016462 ! pyrophosphatase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0034354 +name: 'de novo' NAD biosynthetic process from tryptophan +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [PMID:17161604] +synonym: "de novo NAD biosynthetic process from tryptophan" RELATED [] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0034627 ! 'de novo' NAD biosynthetic process + +[Term] +id: GO:0034355 +name: NAD salvage +namespace: biological_process +def: "Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam)." [GOC:mah, PMID:12648681] +synonym: "NAD salvage pathway" EXACT [] +is_a: GO:0009435 ! NAD biosynthetic process +is_a: GO:0019365 ! pyridine nucleotide salvage + +[Term] +id: GO:0034356 +name: NAD biosynthesis via nicotinamide riboside salvage pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside." [PMID:17482543] +synonym: "nicotinamide riboside salvage pathway" EXACT [] +synonym: "NR salvage pathway" EXACT [] +is_a: GO:0009435 ! NAD biosynthetic process + +[Term] +id: GO:0034357 +name: photosynthetic membrane +namespace: cellular_component +def: "A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place." [GOC:ds, GOC:mah] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0009579 ! thylakoid + +[Term] +id: GO:0034358 +name: plasma lipoprotein particle +namespace: cellular_component +def: "A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph." [GOC:BHF, GOC:expert_pt, GOC:rl] +is_a: GO:1990777 ! lipoprotein particle +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0034359 +name: mature chylomicron +namespace: cellular_component +def: "A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0042627 ! chylomicron + +[Term] +id: GO:0034360 +name: chylomicron remnant +namespace: cellular_component +def: "A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0042627 ! chylomicron + +[Term] +id: GO:0034361 +name: very-low-density lipoprotein particle +namespace: cellular_component +def: "A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "very-low-density lipoprotein complex" EXACT [] +synonym: "VLDL complex" EXACT [] +synonym: "VLDL particle" EXACT [] +is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle + +[Term] +id: GO:0034362 +name: low-density lipoprotein particle +namespace: cellular_component +def: "A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "LDL complex" EXACT [] +synonym: "LDL particle" EXACT [] +synonym: "low-density lipoprotein complex" EXACT [] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034363 +name: intermediate-density lipoprotein particle +namespace: cellular_component +def: "A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL complex" EXACT [] +synonym: "IDL particle" EXACT [] +synonym: "intermediate-density lipoprotein complex" EXACT [] +is_a: GO:0034385 ! triglyceride-rich plasma lipoprotein particle + +[Term] +id: GO:0034364 +name: high-density lipoprotein particle +namespace: cellular_component +def: "A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:pde, GOC:rl] +synonym: "HDL complex" EXACT [] +synonym: "HDL particle" EXACT [] +synonym: "HDL2" RELATED [] +synonym: "HDL3" RELATED [] +synonym: "high-density lipoprotein class complex" EXACT [] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034365 +name: discoidal high-density lipoprotein particle +namespace: cellular_component +def: "A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "discoidal HDL" EXACT [] +synonym: "nascent HDL" EXACT [] +synonym: "nascent high-density lipoprotein particle" EXACT [] +is_a: GO:0034364 ! high-density lipoprotein particle + +[Term] +id: GO:0034366 +name: spherical high-density lipoprotein particle +namespace: cellular_component +def: "A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "mature HDL" EXACT [] +synonym: "mature high-density lipoprotein particle" EXACT [] +synonym: "spherical HDL" EXACT [] +is_a: GO:0034364 ! high-density lipoprotein particle + +[Term] +id: GO:0034367 +name: protein-containing complex remodeling +namespace: biological_process +def: "The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." [GOC:BHF, GOC:mah, GOC:mtg_mpo, GOC:rl] +synonym: "macromolecular complex remodeling" RELATED [] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0034368 +name: protein-lipid complex remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a protein-lipid complex." [GOC:BHF, GOC:mah, GOC:rl] +is_a: GO:0034367 ! protein-containing complex remodeling +is_a: GO:0071825 ! protein-lipid complex subunit organization + +[Term] +id: GO:0034369 +name: plasma lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT)." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +is_a: GO:0034368 ! protein-lipid complex remodeling +is_a: GO:0071827 ! plasma lipoprotein particle organization +relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels + +[Term] +id: GO:0034370 +name: triglyceride-rich lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "triacylglycerol-rich lipoprotein particle remodeling" EXACT [GOC:mah] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034371 +name: chylomicron remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "chylomicron remnant formation" RELATED [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034372 +name: very-low-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL formation" RELATED [] +synonym: "intermediate-density lipoprotein particle formation" RELATED [] +synonym: "VLDL remodeling" EXACT [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034373 +name: intermediate-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within an intermediate-density lipoprotein particle." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "IDL remodeling" EXACT [] +synonym: "LDL formation" RELATED [] +synonym: "low-density lipoprotein particle formation" RELATED [] +is_a: GO:0034370 ! triglyceride-rich lipoprotein particle remodeling + +[Term] +id: GO:0034374 +name: low-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "LDL remodeling" EXACT [] +synonym: "small dense LDL formation" RELATED [GOC:BHF] +synonym: "small dense low-density lipoprotein particle formation" RELATED [GOC:BHF] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034375 +name: high-density lipoprotein particle remodeling +namespace: biological_process +def: "The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL." [GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl] +synonym: "HDL remodeling" EXACT [] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034376 +name: conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle +namespace: biological_process +def: "The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle." [GOC:BHF, GOC:mah, GOC:pde] +synonym: "conversion of discoidal HDL to spherical HDL" EXACT [] +synonym: "discoidal HDL remodeling" RELATED [] +synonym: "discoidal high-density lipoprotein remodeling" RELATED [] +is_a: GO:0034375 ! high-density lipoprotein particle remodeling + +[Term] +id: GO:0034377 +name: plasma lipoprotein particle assembly +namespace: biological_process +def: "The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle." [GOC:BHF, GOC:mah] +is_a: GO:0065005 ! protein-lipid complex assembly +is_a: GO:0071827 ! plasma lipoprotein particle organization +relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels + +[Term] +id: GO:0034378 +name: chylomicron assembly +namespace: biological_process +def: "The non-covalent aggregation and arrangement of proteins and lipids in the intestine to form a chylomicron." [GOC:BHF, GOC:mah] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034379 +name: very-low-density lipoprotein particle assembly +namespace: biological_process +def: "The non-covalent aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle." [GOC:BHF, GOC:mah] +synonym: "VLDL assembly" EXACT [] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034380 +name: high-density lipoprotein particle assembly +namespace: biological_process +def: "The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:mah] +synonym: "HDL assembly" EXACT [] +is_a: GO:0034377 ! plasma lipoprotein particle assembly + +[Term] +id: GO:0034381 +name: plasma lipoprotein particle clearance +namespace: biological_process +def: "The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:mah, GOC:tb] +synonym: "lipoprotein particle clearance" EXACT [GOC:mah] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels + +[Term] +id: GO:0034382 +name: chylomicron remnant clearance +namespace: biological_process +def: "The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF, GOC:mah, GOC:pde] +is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance + +[Term] +id: GO:0034383 +name: low-density lipoprotein particle clearance +namespace: biological_process +def: "The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] +synonym: "LDL clearance" EXACT [] +is_a: GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0034384 +name: high-density lipoprotein particle clearance +namespace: biological_process +def: "The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:mah] +synonym: "HDL clearance" EXACT [] +is_a: GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0034385 +name: triglyceride-rich plasma lipoprotein particle +namespace: cellular_component +def: "A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood." [GOC:BHF, GOC:mah, GOC:rl] +synonym: "triacylglycerol-rich lipoprotein particle" NARROW [GOC:mah] +synonym: "triglyceride-rich lipoprotein particle" BROAD [GOC:mah] +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0034386 +name: 4-aminobutyrate:2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate." [EC:2.6.1.19, GOC:mah] +synonym: "4-aminobutanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "4-aminobutyrate-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-alpha-ketoglutaric acid transaminase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-alpha-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "GABA-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyrate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.19] +synonym: "gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity" RELATED [EC:2.6.1.19] +xref: EC:2.6.1.19 +xref: MetaCyc:GABATRANSAM-RXN +is_a: GO:0003867 ! 4-aminobutyrate transaminase activity + +[Term] +id: GO:0034387 +name: 4-aminobutyrate:pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine." [EC:2.6.1.96, GOC:mah] +synonym: "gamma-aminobutyric acid pyruvate transaminase activity" RELATED [EC:2.6.1.96] +xref: EC:2.6.1.96 +xref: MetaCyc:RXN-6902 +xref: RHEA:32263 +is_a: GO:0003867 ! 4-aminobutyrate transaminase activity + +[Term] +id: GO:0034388 +name: Pwp2p-containing subcomplex of 90S preribosome +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p." [GOC:krc, PMID:15231838] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "25-30 S subcomplex of 90S preribosome" EXACT [] +synonym: "UTP-B complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034389 +name: lipid droplet organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] +synonym: "adiposome organization" EXACT [] +synonym: "lipid body organization" EXACT [] +synonym: "lipid particle organisation" EXACT [] +synonym: "lipid particle organization" EXACT [] +synonym: "lipid particle organization and biogenesis" BROAD [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0034390 +name: smooth muscle cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels." [CL:0000192, GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] +synonym: "apoptosis of smooth muscle cells" EXACT [] +synonym: "programmed cell death of smooth muscle cells by apoptosis" EXACT [] +synonym: "programmed cell death, smooth muscle cells" EXACT [] +synonym: "SMC apoptosis" EXACT [] +synonym: "smooth muscle cell apoptosis" NARROW [] +synonym: "smooth muscle cell programmed cell death by apoptosis" EXACT [] +is_a: GO:0010657 ! muscle cell apoptotic process + +[Term] +id: GO:0034391 +name: regulation of smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] +synonym: "regulation of SMC apoptosis" EXACT [] +synonym: "regulation of smooth muscle cell apoptosis" NARROW [] +is_a: GO:0010660 ! regulation of muscle cell apoptotic process +relationship: regulates GO:0034390 ! smooth muscle cell apoptotic process + +[Term] +id: GO:0034392 +name: negative regulation of smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] +synonym: "down regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "down-regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "downregulation of smooth muscle cell apoptosis" EXACT [] +synonym: "inhibition of smooth muscle cell apoptosis" NARROW [] +synonym: "negative regulation of SMC apoptosis" EXACT [] +synonym: "negative regulation of smooth muscle cell apoptosis" NARROW [] +is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process +is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process +relationship: negatively_regulates GO:0034390 ! smooth muscle cell apoptotic process + +[Term] +id: GO:0034393 +name: positive regulation of smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl] +synonym: "activation of smooth muscle cell apoptosis" NARROW [] +synonym: "positive regulation of SMC apoptosis" EXACT [] +synonym: "positive regulation of smooth muscle cell apoptosis" NARROW [] +synonym: "stimulation of smooth muscle cell apoptosis" NARROW [] +synonym: "up regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "up-regulation of smooth muscle cell apoptosis" EXACT [] +synonym: "upregulation of smooth muscle cell apoptosis" EXACT [] +is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process +is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process +relationship: positively_regulates GO:0034390 ! smooth muscle cell apoptotic process + +[Term] +id: GO:0034394 +name: protein localization to cell surface +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah] +synonym: "protein localisation at cell surface" EXACT [GOC:mah] +synonym: "protein localization at cell surface" EXACT [] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0034395 +name: regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GO_REF:0000021, GOC:mah] +synonym: "regulation of specific transcription from RNA polymerase II promoter in response to iron" EXACT [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: part_of GO:0071281 ! cellular response to iron ion + +[Term] +id: GO:0034396 +name: negative regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:mah] +synonym: "down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [] +synonym: "negative regulation of transcription from Pol II promoter in response to iron" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron + +[Term] +id: GO:0034397 +name: telomere localization +namespace: biological_process +def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah, GOC:vw] +synonym: "telomere localisation" EXACT [GOC:mah] +is_a: GO:0050000 ! chromosome localization + +[Term] +id: GO:0034398 +name: telomere tethering at nuclear periphery +namespace: biological_process +def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah] +is_a: GO:0034397 ! telomere localization + +[Term] +id: GO:0034399 +name: nuclear periphery +namespace: cellular_component +def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0034400 +name: gerontoplast +namespace: cellular_component +def: "A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence." [PMID:12654863, PMID:24668747] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0034401 +name: obsolete chromatin organization involved in regulation of transcription +namespace: biological_process +alt_id: GO:1903756 +alt_id: GO:1903757 +def: "OBSOLETE. Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators, PMID:21102443] +comment: This term was obsoleted because these it was redundant with other terms: heterochromatin assembly and regulation of gene expression, epigenetic. +synonym: "activation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah] +synonym: "regulation of transcription by chromatin organization" EXACT [] +synonym: "regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] +synonym: "regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:0034402 +name: recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex +namespace: biological_process +def: "The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript." [PMID:18195044] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0034403 +name: alignment of 3' and 5' splice sites of mRNA +namespace: biological_process +def: "Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur." [GOC:krc, PMID:9430647] +synonym: "alignment of 3' and 5' splice sites of nuclear mRNA" EXACT [GOC:vw] +is_a: GO:0000389 ! mRNA 3'-splice site recognition +is_a: GO:0000395 ! mRNA 5'-splice site recognition +relationship: part_of GO:0000350 ! generation of catalytic spliceosome for second transesterification step + +[Term] +id: GO:0034404 +name: nucleobase-containing small molecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah] +synonym: "nucleobase, nucleoside and nucleotide anabolism" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide biosynthesis" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide formation" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide synthesis" EXACT [] +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process + +[Term] +id: GO:0034405 +name: response to fluid shear stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:sl] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0034406 +name: cell wall beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall beta-glucan metabolism" EXACT [] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0034407 +name: cell wall (1->3)-beta-D-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall 1,3-beta-D-glucan metabolic process" EXACT [] +synonym: "cell wall 1,3-beta-glucan metabolic process" BROAD [] +synonym: "cell wall 1,3-beta-glucan metabolism" EXACT [] +synonym: "cell wall beta-1,3 glucan metabolic process" EXACT [] +synonym: "cell wall beta-1,3 glucan metabolism" EXACT [] +is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process +is_a: GO:0034406 ! cell wall beta-glucan metabolic process + +[Term] +id: GO:0034408 +name: ascospore wall beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall beta-glucan metabolism" EXACT [] +is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0070591 ! ascospore wall biogenesis + +[Term] +id: GO:0034409 +name: ascospore wall (1->3)-beta-D-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall 1,3-beta-D-glucan metabolic process" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan metabolic process" BROAD [] +synonym: "ascospore wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] +synonym: "ascospore wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "ascospore wall beta-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process +is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process + +[Term] +id: GO:0034410 +name: cell wall beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall beta-glucan anabolism" EXACT [] +synonym: "cell wall beta-glucan biosynthesis" EXACT [] +synonym: "cell wall beta-glucan formation" EXACT [] +synonym: "cell wall beta-glucan synthesis" EXACT [] +is_a: GO:0034406 ! cell wall beta-glucan metabolic process +is_a: GO:0051274 ! beta-glucan biosynthetic process +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0034411 +name: cell wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall 1,3-beta-D-glucan biosynthetic process" BROAD [] +synonym: "cell wall 1,3-beta-glucan anabolism" EXACT [] +synonym: "cell wall 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "cell wall 1,3-beta-glucan biosynthetic process" BROAD [] +synonym: "cell wall 1,3-beta-glucan formation" EXACT [] +synonym: "cell wall 1,3-beta-glucan synthesis" EXACT [] +synonym: "cell wall beta-1,3-glucan anabolism" EXACT [] +synonym: "cell wall beta-1,3-glucan biosynthesis" EXACT [] +synonym: "cell wall beta-1,3-glucan biosynthetic process" EXACT [] +synonym: "cell wall beta-1,3-glucan formation" EXACT [] +synonym: "cell wall beta-1,3-glucan synthesis" EXACT [] +is_a: GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process +is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process +is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process + +[Term] +id: GO:0034412 +name: ascospore wall beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall beta-glucan anabolism" EXACT [] +synonym: "ascospore wall beta-glucan biosynthesis" EXACT [] +synonym: "ascospore wall beta-glucan formation" EXACT [] +synonym: "ascospore wall beta-glucan synthesis" EXACT [] +is_a: GO:0034408 ! ascospore wall beta-glucan metabolic process +is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process + +[Term] +id: GO:0034413 +name: ascospore wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD [] +synonym: "ascospore wall 1,3-beta-glucan anabolism" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan biosynthesis" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] +synonym: "ascospore wall 1,3-beta-glucan formation" EXACT [] +synonym: "ascospore wall 1,3-beta-glucan synthesis" EXACT [] +synonym: "ascospore wall beta-1,3-glucan anabolism" EXACT [] +synonym: "ascospore wall beta-1,3-glucan biosynthesis" EXACT [] +synonym: "ascospore wall beta-1,3-glucan biosynthetic process" EXACT [] +synonym: "ascospore wall beta-1,3-glucan formation" EXACT [] +synonym: "ascospore wall beta-1,3-glucan synthesis" EXACT [] +is_a: GO:0034409 ! ascospore wall (1->3)-beta-D-glucan metabolic process +is_a: GO:0034412 ! ascospore wall beta-glucan biosynthetic process +is_a: GO:0071970 ! fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0034414 +name: tRNA 3'-trailer cleavage, endonucleolytic +namespace: biological_process +def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] +synonym: "endonucleolytic tRNA 3'-end cleavage" EXACT [] +synonym: "endonucleolytic tRNA 3'-trailer cleavage" RELATED [] +synonym: "tRNA 3'-end cleavage, endonucleolytic" EXACT [] +is_a: GO:0042779 ! tRNA 3'-trailer cleavage +is_a: GO:1905267 ! endonucleolytic cleavage involved in tRNA processing + +[Term] +id: GO:0034415 +name: tRNA 3'-trailer cleavage, exonucleolytic +namespace: biological_process +def: "Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA." [GOC:mah] +synonym: "exonucleolytic tRNA 3'-end cleavage" EXACT [] +synonym: "exonucleolytic tRNA 3'-trailer cleavage" EXACT [] +synonym: "tRNA 3'-end cleavage, exonucleolytic" EXACT [] +is_a: GO:0042779 ! tRNA 3'-trailer cleavage +is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic + +[Term] +id: GO:0034416 +name: bisphosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate." [EC:3.1.3.80, GOC:mah, PMID:18413611] +synonym: "2,3-bisphosphoglycerate phosphatase activity" EXACT [] +synonym: "2,3-diphosphoglycerate phosphatase activity" EXACT [] +synonym: "2,3-diphosphoglyceric acid phosphatase activity" EXACT [] +synonym: "diphosphoglycerate phosphatase activity" EXACT [] +synonym: "glycerate-2,3-diphosphate phosphatase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0034417 +name: bisphosphoglycerate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate." [EC:3.1.3.80, GOC:mah, PMID:18413611] +synonym: "2,3-bisphospho-D-glycerate 3-phosphohydrolase activity" RELATED [EC:3.1.3.80] +xref: EC:3.1.3.80 +xref: KEGG_REACTION:R09532 +xref: MetaCyc:RXN-11102 +xref: RHEA:27381 +is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity + +[Term] +id: GO:0034418 +name: urate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine." [GOC:mah] +synonym: "urate anabolism" RELATED [] +synonym: "urate biosynthesis" EXACT [] +synonym: "urate formation" EXACT [] +synonym: "urate synthesis" EXACT [] +synonym: "uric acid biosynthetic process" EXACT [] +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:0046415 ! urate metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0034419 +name: obsolete L-2-hydroxyglutarate oxidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-2-hydroxyglutarate + O2 = 2-oxoglutarate + hydrogen peroxide." [PMID:18390652] +comment: This term was obsoleted because this activity is not believed to exist. +is_obsolete: true +consider: GO:0140696 + +[Term] +id: GO:0034420 +name: co-translational protein acetylation +namespace: biological_process +def: "The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome." [GOC:mah] +synonym: "co-translational protein amino acid acetylation" EXACT [GOC:bf] +synonym: "cotranslational protein amino acid acetylation" EXACT [] +is_a: GO:0006473 ! protein acetylation +is_a: GO:0043686 ! co-translational protein modification + +[Term] +id: GO:0034421 +name: post-translational protein acetylation +namespace: biological_process +def: "The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome." [GOC:mah] +synonym: "post-translational protein amino acid acetylation" EXACT [GOC:bf] +synonym: "posttranslational protein amino acid acetylation" EXACT [] +is_a: GO:0006473 ! protein acetylation +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0034422 +name: aleurone grain lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an aleurone grain." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0033095 ! aleurone grain + +[Term] +id: GO:0034423 +name: autophagosome lumen +namespace: cellular_component +def: "The volume enclosed within the autophagosome double-membrane." [GOC:autophagy, GOC:rph] +comment: Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. +synonym: "autophagic vacuole lumen" EXACT [GOC:autophagy] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0005776 ! autophagosome + +[Term] +id: GO:0034424 +name: Vps55/Vps68 complex +namespace: cellular_component +def: "A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins." [PMID:18216282] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0034425 +name: etioplast envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] +is_a: GO:0009526 ! plastid envelope +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0034426 +name: etioplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a etioplast and form the etioplast envelope." [GOC:rph] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0034425 ! etioplast envelope + +[Term] +id: GO:0034427 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [GOC:krc, GOC:mah] +synonym: "3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic + +[Term] +id: GO:0034428 +name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah] +synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic + +[Term] +id: GO:0034429 +name: tectobulbar tract morphogenesis +namespace: biological_process +def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain." [GOC:dsf, PMID:15065115, PMID:17507550, PMID:8038988] +is_a: GO:0021952 ! central nervous system projection neuron axonogenesis + +[Term] +id: GO:0034430 +name: monolayer-surrounded lipid storage body outer lipid monolayer +namespace: cellular_component +def: "The single layer of phopholipids surrounding a lipid storage body." [GOC:rph] +synonym: "lipid droplet outer lipid monolayer" RELATED [] +synonym: "lipid storage body surface lipid monolayer" EXACT [] +synonym: "oil body outer lipid monolayer" EXACT [] +synonym: "oleosome outer lipid monolayer" EXACT [] +synonym: "spherosome outer lipid monolayer" EXACT [] +is_a: GO:0034646 ! organelle-enclosing lipid monolayer +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0012511 ! monolayer-surrounded lipid storage body + +[Term] +id: GO:0034431 +name: bis(5'-adenosyl)-hexaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008, RHEA:32047] +synonym: "AP(6)A hydrolase activity" EXACT [] +synonym: "AP-6-A hydrolase activity" EXACT [] +synonym: "AP6A hydrolase activity" EXACT [] +synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] +xref: RHEA:32047 +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0034432 +name: bis(5'-adenosyl)-pentaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate." [PMID:10085096, PMID:9450008] +synonym: "AP(5)A hydrolase activity" EXACT [] +synonym: "AP-5-A hydrolase activity" EXACT [] +synonym: "AP5A hydrolase activity" EXACT [] +synonym: "Ap5a pyrophosphohydrolase activity" EXACT [GOC:tb] +synonym: "diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity" EXACT [] +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0034433 +name: steroid esterification +namespace: biological_process +def: "A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034434 +name: sterol esterification +namespace: biological_process +def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol)." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] +is_a: GO:0034433 ! steroid esterification + +[Term] +id: GO:0034435 +name: cholesterol esterification +namespace: biological_process +def: "A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:mah, GOC:pde, GOC:rl] +is_a: GO:0034434 ! sterol esterification + +[Term] +id: GO:0034436 +name: glycoprotein transport +namespace: biological_process +def: "The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah, GOC:rl] +is_a: GO:0015031 ! protein transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0034437 +name: obsolete glycoprotein transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a glycoprotein from one side of a membrane to the other." [GOC:BHF, GOC:mah, GOC:rl] +comment: This term was obsoleted because there is no transmembrane transporter specific for glycoproteins. +synonym: "glycoprotein transporter activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0034438 +name: lipoprotein amino acid oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of one or more amino acids in the protein." [GOC:BHF, GOC:mah] +is_a: GO:0018158 ! protein oxidation +is_a: GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034439 +name: lipoprotein lipid oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:mah] +is_a: GO:0034440 ! lipid oxidation +is_a: GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034440 +name: lipid oxidation +namespace: biological_process +def: "The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GOC:BHF, GOC:mah] +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0034441 +name: plasma lipoprotein particle oxidation +namespace: biological_process +def: "The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids." [GOC:BHF, GOC:mah] +synonym: "plasma lipoprotein oxidation" RELATED [GOC:dph] +is_a: GO:0034369 ! plasma lipoprotein particle remodeling + +[Term] +id: GO:0034442 +name: regulation of lipoprotein oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +relationship: regulates GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034443 +name: negative regulation of lipoprotein oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein oxidation." [GOC:BHF, GOC:mah] +synonym: "inhibition of lipoprotein oxidation" NARROW [] +is_a: GO:0034442 ! regulation of lipoprotein oxidation +is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process +relationship: negatively_regulates GO:0042161 ! lipoprotein oxidation + +[Term] +id: GO:0034444 +name: regulation of plasma lipoprotein oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipoprotein oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] +synonym: "regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0034441 ! plasma lipoprotein particle oxidation + +[Term] +id: GO:0034445 +name: negative regulation of plasma lipoprotein oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lipoprotein particle oxidation, occurring in the blood plasma." [GOC:BHF, GOC:mah] +synonym: "inhibition of plasma lipoprotein oxidation" NARROW [] +synonym: "negative regulation of plasma lipoprotein particle oxidation" RELATED [GOC:dph] +is_a: GO:0034444 ! regulation of plasma lipoprotein oxidation +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0034441 ! plasma lipoprotein particle oxidation + +[Term] +id: GO:0034446 +name: substrate adhesion-dependent cell spreading +namespace: biological_process +def: "The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate." [GOC:mah, GOC:pf, PMID:17050732] +synonym: "cell spreading during cell substrate adhesion" EXACT [] +synonym: "substrate adhesion dependent cell spreading" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0034447 +name: very-low-density lipoprotein particle clearance +namespace: biological_process +def: "The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:rl] +synonym: "VLDL clearance" EXACT [] +is_a: GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0034450 +name: ubiquitin-ubiquitin ligase activity +namespace: molecular_function +def: "Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603] +synonym: "E4" EXACT [] +xref: Reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1" +xref: Reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
" +is_a: GO:0061630 ! ubiquitin protein ligase activity + +[Term] +id: GO:0034451 +name: centriolar satellite +namespace: cellular_component +def: "A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome." [GOC:BHF, PMID:10579718, PMID:12403812] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005813 ! centrosome + +[Term] +id: GO:0034452 +name: dynactin binding +namespace: molecular_function +def: "Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity." [GOC:BHF, GOC:mah] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0034453 +name: microtubule anchoring +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0034454 +name: microtubule anchoring at centrosome +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." [GOC:BHF, GOC:mah] +is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center + +[Term] +id: GO:0034455 +name: t-UTP complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p." [GOC:krc, GOC:mah, GOC:vw, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "Nan1p-containing subcomplex of 90S preribosome" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0034456 +name: UTP-C complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p." [GOC:mah, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +synonym: "Rrp7p-containing subcomplex of 90S preribosome" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034457 +name: Mpp10 complex +namespace: cellular_component +def: "A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p." [GOC:mah, PMID:17515605] +comment: Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0034458 +name: 3'-5' RNA helicase activity +namespace: molecular_function +alt_id: GO:0034459 +def: "Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis." [GOC:jp] +synonym: "3' to 5' RNA helicase activity" EXACT [] +synonym: "ATP-dependent 3' to 5' RNA helicase activity" EXACT [] +synonym: "ATP-dependent 3'-5' RNA helicase activity" EXACT [] +is_a: GO:0003724 ! RNA helicase activity + +[Term] +id: GO:0034460 +name: uropod assembly +namespace: biological_process +def: "The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane." [GOC:mah] +synonym: "uropod formation" EXACT [GOC:mah] +is_a: GO:0032796 ! uropod organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0034461 +name: uropod retraction +namespace: biological_process +def: "The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell." [GOC:mah, PMID:10704379] +is_a: GO:0032796 ! uropod organization + +[Term] +id: GO:0034462 +name: small-subunit processome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome." [GOC:mah] +synonym: "small subunit processome assembly" EXACT [] +synonym: "SSU processome assembly" EXACT [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000028 ! ribosomal small subunit assembly + +[Term] +id: GO:0034463 +name: 90S preribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions." [GOC:krc, GOC:mah, GOC:tb] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0000027 ! ribosomal large subunit assembly +relationship: part_of GO:0000028 ! ribosomal small subunit assembly + +[Term] +id: GO:0034464 +name: BBSome +namespace: cellular_component +def: "A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B." [GOC:BHF, GOC:cilia, PMID:15231740, PMID:17574030, PMID:26498262] +synonym: "Bardet-Biedl syndrome complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0034465 +name: response to carbon monoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:ecd] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0034466 +name: chromaffin granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a chromaffin granule." [GOC:rph] +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0042583 ! chromaffin granule + +[Term] +id: GO:0034467 +name: esterosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an esterosome." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0033117 ! esterosome + +[Term] +id: GO:0034468 +name: glycosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a glycosome." [GOC:rph] +is_a: GO:0005782 ! peroxisomal matrix +relationship: part_of GO:0020015 ! glycosome + +[Term] +id: GO:0034469 +name: Golgi stack lumen +namespace: cellular_component +def: "The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex." [GOC:mah] +is_a: GO:0005796 ! Golgi lumen +relationship: part_of GO:0005795 ! Golgi stack + +[Term] +id: GO:0034470 +name: ncRNA processing +namespace: biological_process +alt_id: GO:0031050 +def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah] +synonym: "double-stranded RNA fragmentation" RELATED [] +synonym: "dsRNA fragmentation" RELATED [] +synonym: "dsRNA processing" RELATED [] +is_a: GO:0006396 ! RNA processing +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034471 +name: ncRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah] +synonym: "ncRNA 5' end processing" EXACT [] +is_a: GO:0000966 ! RNA 5'-end processing +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0034472 +name: snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] +synonym: "snRNA 3' end processing" EXACT [] +is_a: GO:0016180 ! snRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0034473 +name: U1 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U1 snRNA molecule." [GOC:mah] +synonym: "U1 snRNA 3' end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034474 +name: U2 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U2 snRNA molecule." [GOC:mah] +synonym: "U2 snRNA 3' end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034475 +name: U4 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U4 snRNA molecule." [GOC:mah] +synonym: "U4 snRNA 3' end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034476 +name: U5 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U5 snRNA molecule." [GOC:mah] +synonym: "U5 snRNA 3' end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034477 +name: U6 snRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a U6 snRNA molecule." [GOC:mah] +synonym: "U6 snRNA 3' end processing" EXACT [] +is_a: GO:0034472 ! snRNA 3'-end processing + +[Term] +id: GO:0034478 +name: phosphatidylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylglycerols, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [GOC:mah] +synonym: "phosphatidylglycerol breakdown" EXACT [] +synonym: "phosphatidylglycerol catabolism" EXACT [] +synonym: "phosphatidylglycerol degradation" EXACT [] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0034479 +name: phosphatidylglycerol phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate." [GOC:mah, PMID:18434318] +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0034480 +name: phosphatidylcholine phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate." [EC:3.1.4.3, GOC:mah] +synonym: "alpha-toxin" NARROW [EC:3.1.4.3] +synonym: "Clostridium oedematiens beta- and gamma-toxins activity" NARROW [EC:3.1.4.3] +synonym: "Clostridium welchii alpha-toxin activity" NARROW [EC:3.1.4.3] +synonym: "heat-labile hemolysin" NARROW [EC:3.1.4.3] +synonym: "lipophosphodiesterase I activity" RELATED [EC:3.1.4.3] +synonym: "phosphatidylcholine cholinephosphohydrolase activity" RELATED [EC:3.1.4.3] +synonym: "phospholipase C, acting on phosphatidylcholine" EXACT [] +xref: EC:3.1.4.3 +xref: MetaCyc:PHOSPHOLIPASE-C-RXN +xref: RHEA:10604 +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0034481 +name: chondroitin sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate." [EC:2.8.2.17, EC:2.8.2.5, GOC:mah] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034482 +name: chondroitin 2-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues." [PMID:17227754] +synonym: "chondroitin 2-O-sulphotransferase activity" EXACT [] +synonym: "chondroitin 2-sulfotransferase activity" EXACT [] +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0034483 +name: heparan sulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate." [GOC:mah] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034484 +name: raffinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside." [GOC:mah] +synonym: "raffinose breakdown" EXACT [] +synonym: "raffinose catabolism" EXACT [] +synonym: "raffinose degradation" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0033530 ! raffinose metabolic process + +[Term] +id: GO:0034485 +name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate." [GOC:pf] +xref: MetaCyc:RXN-10036 +xref: Reactome:R-HSA-1675949 "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane" +xref: RHEA:25528 +is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity +is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity + +[Term] +id: GO:0034486 +name: vacuolar transmembrane transport +namespace: biological_process +def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "vacuolar membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034487 +name: vacuolar amino acid transmembrane transport +namespace: biological_process +def: "The process in which an amino acid is transported from one side of the vacuolar membrane to the other." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "vacuolar amino acid membrane transport" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport + +[Term] +id: GO:0034488 +name: basic amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0034487 ! vacuolar amino acid transmembrane transport +is_a: GO:1990822 ! basic amino acid transmembrane transport + +[Term] +id: GO:0034489 +name: neutral amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032974 ! amino acid transmembrane export from vacuole + +[Term] +id: GO:0034490 +name: basic amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +is_a: GO:1990822 ! basic amino acid transmembrane transport + +[Term] +id: GO:0034491 +name: neutral amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole + +[Term] +id: GO:0034492 +name: hydrogenosome lumen +namespace: cellular_component +def: "The volume enclosed by the hydrogenosome membrane." [GOC:rph] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0042566 ! hydrogenosome + +[Term] +id: GO:0034493 +name: melanosome lumen +namespace: cellular_component +def: "The volume enclosed by the melanosome membrane." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0042470 ! melanosome + +[Term] +id: GO:0034494 +name: microneme lumen +namespace: cellular_component +def: "The volume enclosed by the microneme membrane." [GOC:rph] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0020009 ! microneme + +[Term] +id: GO:0034495 +name: protein storage vacuole lumen +namespace: cellular_component +def: "The volume enclosed by the protein storage vacuole membrane." [GOC:rph] +is_a: GO:0000330 ! plant-type vacuole lumen +relationship: part_of GO:0000326 ! protein storage vacuole + +[Term] +id: GO:0034496 +name: multivesicular body membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the membranes of multivesicular bodies." [GOC:rb] +synonym: "MVB membrane disassembly" EXACT [] +is_a: GO:0030397 ! membrane disassembly +relationship: part_of GO:0036257 ! multivesicular body organization + +[Term] +id: GO:0034497 +name: protein localization to phagophore assembly site +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS)." [GOC:rb] +synonym: "protein localisation to phagophore assembly site" EXACT [GOC:mah] +synonym: "protein localization to PAS" EXACT [] +synonym: "protein localization to pre-autophagosomal structure" NARROW [] +is_a: GO:0034613 ! cellular protein localization +relationship: part_of GO:0000045 ! autophagosome assembly + +[Term] +id: GO:0034498 +name: early endosome to Golgi transport +namespace: biological_process +def: "The directed movement of substances from early endosomes to the Golgi." [GOC:rb] +synonym: "PGE to Golgi transport" EXACT [] +synonym: "post-Golgi endosome to Golgi transport" EXACT [] +is_a: GO:0042147 ! retrograde transport, endosome to Golgi +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0034499 +name: late endosome to Golgi transport +namespace: biological_process +def: "The directed movement of substances from late endosomes to the Golgi." [GOC:rb] +synonym: "prevacuolar endosome to Golgi transport" EXACT [] +synonym: "PVE to Golgi transport" EXACT [] +is_a: GO:0042147 ! retrograde transport, endosome to Golgi +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0034501 +name: protein localization to kinetochore +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] +synonym: "condensin localization to kinetochore" NARROW [] +synonym: "protein localisation to kinetochore" EXACT [GOC:mah] +is_a: GO:0071459 ! protein localization to chromosome, centromeric region +is_a: GO:1903083 ! protein localization to condensed chromosome + +[Term] +id: GO:0034502 +name: protein localization to chromosome +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] +synonym: "condensin localization to chromosome" NARROW [] +synonym: "protein localisation to chromosome" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0034503 +name: protein localization to nucleolar rDNA repeats +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus." [GOC:mah] +synonym: "condensin localization to nucleolar rDNA repeats" NARROW [] +synonym: "protein localisation to nucleolar rDNA repeats" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome +relationship: part_of GO:0007000 ! nucleolus organization + +[Term] +id: GO:0034504 +name: protein localization to nucleus +namespace: biological_process +alt_id: GO:0044744 +def: "A process in which a protein transports or maintains the localization of another protein to the nucleus." [GOC:ecd] +synonym: "protein localisation to nucleus" EXACT [GOC:mah] +synonym: "protein localization in cell nucleus" EXACT [] +synonym: "protein localization in nucleus" EXACT [GOC:mah] +synonym: "protein targeting to nucleus" RELATED [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0034505 +name: tooth mineralization +namespace: biological_process +def: "The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum." [GOC:mah, MP:0002817, MSH:D014074] +synonym: "tooth calcification" EXACT [] +is_a: GO:0031214 ! biomineral tissue development +relationship: part_of GO:0042476 ! odontogenesis + +[Term] +id: GO:0034506 +name: chromosome, centromeric core domain +namespace: cellular_component +def: "The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] +synonym: "chromosome, centric core region" RELATED [] +synonym: "chromosome, centromeric core region" EXACT [GOC:vw] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0034507 +name: chromosome, centromeric outer repeat region +namespace: cellular_component +def: "The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it." [GOC:mah, GOC:vw] +synonym: "chromosome, centric outer repeat region" RELATED [] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0034508 +name: centromere complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] +synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "centromere organization" EXACT [GOC:dph, PMID:18923422] +synonym: "chromosome, centromeric region assembly" EXACT [GOC:pr] +is_a: GO:0051276 ! chromosome organization +is_a: GO:0065004 ! protein-DNA complex assembly + +[Term] +id: GO:0034510 +name: centromere separation +namespace: biological_process +def: "The cell cycle process in which centromeres are physically detached from each other during chromosome separation." [GOC:mah] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051304 ! chromosome separation +relationship: part_of GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0034511 +name: U3 snoRNA binding +namespace: molecular_function +def: "Binding to a U3 small nucleolar RNA." [GOC:mah] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034512 +name: box C/D RNA binding +namespace: molecular_function +def: "Binding to a box C/D small nucleolar RNA." [GOC:mah] +synonym: "box C/D snoRNA binding" NARROW [] +synonym: "box C/D sRNA binding" NARROW [] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034513 +name: box H/ACA snoRNA binding +namespace: molecular_function +def: "Binding to a box H/ACA small nucleolar RNA." [GOC:mah] +is_a: GO:0030515 ! snoRNA binding + +[Term] +id: GO:0034514 +name: mitochondrial unfolded protein response +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins." [GOC:mah, PMID:17849004] +synonym: "mtUPR" EXACT [] +is_a: GO:0034620 ! cellular response to unfolded protein + +[Term] +id: GO:0034515 +name: proteasome storage granule +namespace: cellular_component +def: "An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state." [GOC:krc, GOC:rb, PMID:18504300, PMID:30204036] +synonym: "PSG" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034516 +name: response to vitamin B6 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah, GOC:rph] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0034517 +name: ribophagy +namespace: biological_process +def: "The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation." [GOC:autophagy, PMID:18391941] +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0034518 +name: RNA cap binding complex +namespace: cellular_component +def: "Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA." [GOC:mah] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0034519 +name: cytoplasmic RNA cap binding complex +namespace: cellular_component +def: "A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA." [PMID:16405910] +is_a: GO:0034518 ! RNA cap binding complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0034520 +name: 2-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+." [UM-BBD_reactionID:r0772] +xref: EC:1.2.1.- +xref: UM-BBD_reactionID:r0772 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0034521 +name: 1-naphthoic acid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+." [UM-BBD_reactionID:r0773] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0773 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034522 +name: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0774] +xref: UM-BBD_reactionID:r0774 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034523 +name: 3-formylsalicylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide." [UM-BBD_reactionID:r0777] +xref: UM-BBD_reactionID:r0777 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0034524 +name: 2-hydroxyisophthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2." [UM-BBD_reactionID:r0776] +xref: UM-BBD_reactionID:r0776 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034525 +name: 1-naphthaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+." [UM-BBD_reactionID:r0787] +xref: UM-BBD_reactionID:r0787 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034526 +name: 2-methylnaphthalene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0788] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0788 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034527 +name: 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene." [UM-BBD_reactionID:r0790] +xref: UM-BBD_reactionID:r0790 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034528 +name: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." [UM-BBD_reactionID:r0791] +xref: EC:5.3.99.- +xref: UM-BBD_reactionID:r0791 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034529 +name: 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate." [PMID:7710320] +xref: UM-BBD_reactionID:r0792 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034530 +name: 4-hydroxymethylsalicyaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+." [UM-BBD_reactionID:r0767] +xref: EC:1.2.1.- +xref: UM-BBD_reactionID:r0767 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0034531 +name: 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde." [PMID:8042906] +xref: UM-BBD_reactionID:r0766 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034532 +name: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate." [UM-BBD_reactionID:r0765] +xref: EC:5.3.99.- +xref: UM-BBD_reactionID:r0765 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034533 +name: 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate." [UM-BBD_reactionID:r0764] +xref: UM-BBD_reactionID:r0764 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034534 +name: 1-methylnaphthalene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O." [UM-BBD_reactionID:r0795] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0795 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034535 +name: 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+." [UM-BBD_reactionID:r0781] +xref: UM-BBD_reactionID:r0781 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034536 +name: 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate." [UM-BBD_reactionID:r0782] +xref: EC:5.3.99.- +xref: UM-BBD_reactionID:r0782 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0034537 +name: 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde." [PMID:8042906] +xref: UM-BBD_reactionID:r0783 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0034538 +name: 3-methylsalicylaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+." [UM-BBD_reactionID:r0784] +xref: UM-BBD_reactionID:r0784 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034539 +name: 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr." [UM-BBD_reactionID:r0821] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0821 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034540 +name: 3-monobromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr." [UM-BBD_reactionID:r0824] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0824 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034541 +name: dimethylarsinite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH." [UM-BBD_reactionID:r0806] +xref: UM-BBD_reactionID:r0806 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034542 +name: trimethylarsine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O." [UM-BBD_reactionID:r0807] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0807 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034543 +name: 5-aminosalicylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate." [UM-BBD_reactionID:r0809] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0809 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034544 +name: trans-ACOHDA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3." [UM-BBD_reactionID:r0810] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r0810 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034545 +name: fumarylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+." [UM-BBD_reactionID:r0811] +xref: EC:3.7.1.20 +xref: RHEA:26168 +xref: UM-BBD_reactionID:r0811 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034546 +name: 2,4-dichloroaniline reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl." [UM-BBD_reactionID:r0819] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0819 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034547 +name: N-cyclopropylmelamine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3." [UM-BBD_reactionID:r0825] +xref: MetaCyc:RXN-8018 +xref: UM-BBD_reactionID:r0825 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034548 +name: N-cyclopropylammeline deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3." [UM-BBD_reactionID:r0826] +xref: MetaCyc:RXN-8019 +xref: UM-BBD_reactionID:r0826 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034549 +name: N-cyclopropylammelide alkylamino hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid." [UM-BBD_reactionID:r0827] +xref: KEGG_REACTION:R06972 +xref: MetaCyc:RXN-8020 +xref: UM-BBD_reactionID:r0827 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0034550 +name: dimethylarsinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O." [UM-BBD_reactionID:r0838] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0838 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034551 +name: mitochondrial respiratory chain complex III assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane." [GOC:dgf, GOC:mcc] +synonym: "mitochondrial cytochrome bc(1) complex assembly" EXACT [GOC:mcc] +is_a: GO:0017062 ! respiratory chain complex III assembly +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly + +[Term] +id: GO:0034552 +name: respiratory chain complex II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." [GOC:dgf] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0034553 +name: mitochondrial respiratory chain complex II assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane." [GOC:dgf] +is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly +is_a: GO:0034552 ! respiratory chain complex II assembly + +[Term] +id: GO:0034554 +name: 3,3',5-tribromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr." [UM-BBD_reactionID:r0842] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0842 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034555 +name: 3,3'-dibromobisphenol A reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr." [UM-BBD_reactionID:r0844] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0844 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034556 +name: nitrobenzoate nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+." [UM-BBD_reactionID:r0849] +xref: EC:1.7.1.- +xref: UM-BBD_reactionID:r0849 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0034557 +name: 2-hydroxylaminobenzoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O." [MetaCyc:RXN-8848] +synonym: "o-hydroxylaminobenzoate nitroreductase activity" RELATED [UM-BBD_reactionID:r0850] +xref: MetaCyc:RXN-8848 +xref: UM-BBD_reactionID:r0850 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0034558 +name: technetium (VII) reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-." [UM-BBD_reactionID:r0859] +xref: UM-BBD_reactionID:r0859 +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0034559 +name: bisphenol A hydroxylase B activity +namespace: molecular_function +def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0860] +xref: UM-BBD_reactionID:r0860 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034560 +name: bisphenol A hydroxylase A activity +namespace: molecular_function +def: "Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O." [UM-BBD_reactionID:r0861] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r0861 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034561 +name: 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O." [UM-BBD_reactionID:r0862] +xref: UM-BBD_reactionID:r0862 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034562 +name: 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O." [UM-BBD_reactionID:r0864] +xref: UM-BBD_reactionID:r0864 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034563 +name: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0867] +xref: UM-BBD_reactionID:r0867 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034564 +name: 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0866] +xref: UM-BBD_reactionID:r0866 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034565 +name: 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol." [UM-BBD_reactionID:r0872] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r0872 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034567 +name: chromate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chromate = chromium (III)." [UM-BBD_reactionID:r0884] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0884 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034568 +name: isoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0892] +xref: EC:1.5.99.- +xref: UM-BBD_reactionID:r0892 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034569 +name: monodemethylisoproturon dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-." [UM-BBD_reactionID:r0893] +xref: EC:1.17.99.- +xref: UM-BBD_reactionID:r0893 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034570 +name: hydroxymonomethylisoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0894] +xref: EC:1.5.99.- +xref: UM-BBD_reactionID:r0894 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034571 +name: 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid." [UM-BBD_reactionID:r0895] +xref: UM-BBD_reactionID:r0895 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034572 +name: monodemethylisoproturon dimethylaminedehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." [UM-BBD_reactionID:r0897] +xref: EC:1.5.99.- +xref: UM-BBD_reactionID:r0897 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034573 +name: didemethylisoproturon amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." [UM-BBD_reactionID:r0898] +xref: UM-BBD_reactionID:r0898 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034574 +name: didemethylisoproturon dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-." [UM-BBD_reactionID:r0899] +xref: EC:1.17.99.- +xref: UM-BBD_reactionID:r0899 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034575 +name: 4-isopropylaniline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-." [UM-BBD_reactionID:r0901] +xref: EC:1.17.99.- +xref: UM-BBD_reactionID:r0901 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0034576 +name: N-isopropylacetanilide amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate." [UM-BBD_reactionID:r0913] +xref: UM-BBD_reactionID:r0913 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034577 +name: N-isopropylacetaniline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone." [UM-BBD_reactionID:r0914] +xref: EC:1.14.15.- +xref: UM-BBD_reactionID:r0914 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034578 +name: limonene 8-hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonene + H2O = alpha-terpineol." [UM-BBD_reactionID:r0916] +xref: UM-BBD_reactionID:r0916 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034579 +name: (1-methylpentyl)succinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate." [UM-BBD_reactionID:r0920] +xref: UM-BBD_reactionID:r0920 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0034580 +name: 4-methyloctanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0924] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r0924 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034581 +name: 4-methyloct-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA." [UM-BBD_reactionID:r0925] +xref: UM-BBD_reactionID:r0925 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034582 +name: 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0926] +xref: UM-BBD_reactionID:r0926 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034583 +name: 21U-RNA binding +namespace: molecular_function +def: "Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0034584 +name: piRNA binding +namespace: molecular_function +def: "Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +synonym: "Piwi-associated RNA binding" EXACT [] +is_a: GO:0061980 ! regulatory RNA binding + +[Term] +id: GO:0034585 +name: 21U-RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +synonym: "21U-RNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034586 +name: 21U-RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome." [GOC:kmv] +synonym: "21U-RNA breakdown" EXACT [] +synonym: "21U-RNA catabolism" EXACT [] +synonym: "21U-RNA degradation" EXACT [] +is_a: GO:0034585 ! 21U-RNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0034587 +name: piRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +subset: goslim_drosophila +synonym: "piRNA metabolism" EXACT [] +synonym: "Piwi-associated RNA metabolic process" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034588 +name: piRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv] +synonym: "piRNA breakdown" EXACT [] +synonym: "piRNA catabolism" EXACT [] +synonym: "piRNA degradation" EXACT [] +synonym: "Piwi-associated RNA catabolic process" EXACT [] +is_a: GO:0034587 ! piRNA metabolic process +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0034589 +name: hydroxyproline transport +namespace: biological_process +def: "The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, PMID:14502423] +synonym: "4-hydroxyproline transport" EXACT [] +synonym: "L-hydroxyproline transport" NARROW [] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0072337 ! modified amino acid transport + +[Term] +id: GO:0034590 +name: L-hydroxyproline transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-hydroxyproline from one side of a membrane to the other." [GOC:mah, PMID:14502423] +synonym: "4-hydroxyproline transmembrane transporter activity" BROAD [] +xref: Reactome:R-HSA-6784213 "Unknown hydroxyproline carrier transports cytosolic HPRO into the mitochondrial matrix" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:0034591 +name: rhoptry lumen +namespace: cellular_component +def: "The volume enclosed by the rhoptry membrane." [GOC:rph, PMID:17997128] +is_a: GO:0043233 ! organelle lumen +relationship: part_of GO:0020008 ! rhoptry + +[Term] +id: GO:0034592 +name: synaptic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the synaptic vesicle membrane." [GOC:rph] +subset: goslim_synapse +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0008021 ! synaptic vesicle + +[Term] +id: GO:0034593 +name: phosphatidylinositol bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate." [GOC:mah] +synonym: "diphosphoinositide phosphatase activity" RELATED [] +synonym: "phosphatidyl-inositol-bisphosphate phosphatase activity" EXACT [] +synonym: "phosphatidylinositol-bisphosphatase activity" RELATED [] +synonym: "triphosphoinositide phosphatase activity" RELATED [] +synonym: "triphosphoinositide phosphomonoesterase activity" RELATED [] +is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity + +[Term] +id: GO:0034594 +name: phosphatidylinositol trisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate." [GOC:mah] +is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity + +[Term] +id: GO:0034595 +name: phosphatidylinositol phosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate." [GOC:elh] +synonym: "phosphoinositide 5-phosphatase activity" EXACT [] +synonym: "polyphosphoinositol lipid 5-phosphatase activity" EXACT [] +is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity + +[Term] +id: GO:0034596 +name: phosphatidylinositol phosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate." [GOC:mah] +synonym: "inositol 4-phosphatase" NARROW [GOC:rl] +synonym: "phosphoinositide 4-phosphatase activity" EXACT [] +synonym: "PI(4)P-phosphatase activity" EXACT [GOC:rl] +synonym: "PI4P-phosphatase activity" EXACT [GOC:rl] +synonym: "PtdIns4P-phosphatase activity" EXACT [GOC:rl] +xref: Reactome:R-HSA-1675988 "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane" +xref: Reactome:R-HSA-1676124 "PI4P is dephosphorylated to PI by SACM1L at the ER membrane" +xref: Reactome:R-HSA-1676133 "PI4P is dephosphorylated to PI by SACM1L at the Golgi membrane" +xref: Reactome:R-HSA-8849969 "PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane" +is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity + +[Term] +id: GO:0034597 +name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] +synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] +synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] +synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity" EXACT [] +xref: EC:3.1.3.66 +xref: MetaCyc:3.1.3.66-RXN +xref: Reactome:R-HSA-6810410 "PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus" +is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity +is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity + +[Term] +id: GO:0034598 +name: phosphothreonine lyase activity +namespace: molecular_function +def: "Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product." [PMID:17303758, PMID:18084305] +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034599 +name: cellular response to oxidative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] +synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] +is_a: GO:0006979 ! response to oxidative stress +is_a: GO:0062197 ! cellular response to chemical stress + +[Term] +id: GO:0034601 +name: oxoglutarate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H." [EC:1.2.1.52, GOC:mah] +xref: EC:1.2.1.52 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034602 +name: oxoglutarate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH." [GOC:mah, RHEA:27786] +xref: EC:1.2.1.105 +xref: KEGG_REACTION:R08549 +xref: MetaCyc:2OXOGLUTARATEDEH-RXN +xref: Reactome:R-HSA-71037 "alpha-ketoadipate + CoASH + NAD+ => glutaryl-CoA + CO2 + NADH + H+" +xref: Reactome:R-HSA-71401 "alpha-ketoglutarate + CoASH + NAD+ => succinyl-CoA + CO2 + NADH + H+" +xref: RHEA:27786 +is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0034603 +name: pyruvate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H." [GOC:mah] +is_a: GO:0004738 ! pyruvate dehydrogenase activity +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034604 +name: pyruvate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH." [GOC:mah, ISBN:0201090910] +xref: KEGG_REACTION:R00209 +xref: MetaCyc:PYRUVDEH-RXN +xref: RHEA:28042 +is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0034605 +name: cellular response to heat +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] +synonym: "cellular response to heat stress" EXACT [] +is_a: GO:0009408 ! response to heat +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034606 +name: response to hermaphrodite contact +namespace: biological_process +def: "The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate." [PMID:18050467, WB_REF:WBPaper00002109] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034607 +name: turning behavior involved in mating +namespace: biological_process +def: "The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [PMID:18050467, WB_REF:WBPaper00002109] +synonym: "turning behavior during mating" EXACT [] +is_a: GO:0035178 ! turning behavior +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034608 +name: vulval location +namespace: biological_process +def: "Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate." [PMID:18050467] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034609 +name: spicule insertion +namespace: biological_process +def: "Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva." [PMID:18050467] +is_a: GO:0060179 ! male mating behavior + +[Term] +id: GO:0034610 +name: oligodeoxyribonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates." [GOC:mah] +synonym: "DNA oligonucleotidase activity" EXACT [] +is_a: GO:0004536 ! deoxyribonuclease activity +is_a: GO:0008946 ! oligonucleotidase activity + +[Term] +id: GO:0034611 +name: oligoribonucleotidase activity +namespace: molecular_function +def: "Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates." [GOC:mah] +synonym: "RNA oligonucleotidase activity" EXACT [] +xref: Reactome:R-HSA-9009950 "PDE12 cleaves 2'-5' oligoadenylates" +xref: Reactome:R-HSA-9615042 "Viral 2',5'-PDE cleaves 2'-5' oligoadenylates" +is_a: GO:0004540 ! ribonuclease activity +is_a: GO:0008946 ! oligonucleotidase activity + +[Term] +id: GO:0034612 +name: response to tumor necrosis factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] +synonym: "response to TNF" EXACT [] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0034613 +name: cellular protein localization +namespace: biological_process +alt_id: GO:0016249 +def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] +synonym: "cellular protein localisation" EXACT [GOC:mah] +synonym: "channel localizer activity" NARROW [GOC:mah] +is_a: GO:0008104 ! protein localization +is_a: GO:0070727 ! cellular macromolecule localization + +[Term] +id: GO:0034614 +name: cellular response to reactive oxygen species +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] +synonym: "cellular response to active oxygen species" EXACT [] +synonym: "cellular response to AOS" EXACT [] +synonym: "cellular response to reactive oxidative species" EXACT [] +synonym: "cellular response to reactive oxygen intermediate" EXACT [] +synonym: "cellular response to ROI" EXACT [] +synonym: "cellular response to ROS" EXACT [] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0034599 ! cellular response to oxidative stress +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0034615 +name: GCH1 complex +namespace: cellular_component +def: "A protein complex that possesses GTP cyclohydrolase I activity. In E. coli and human, the complex is a homodecamer, and monomers are catalytically inactive." [PMID:16696853] +synonym: "GTP cyclohydrolase I complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0034616 +name: response to laminar fluid shear stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." [GOC:ecd] +is_a: GO:0034405 ! response to fluid shear stress + +[Term] +id: GO:0034617 +name: tetrahydrobiopterin binding +namespace: molecular_function +def: "Binding to a tetrahydrobiopterin, 5,6,7,8-tetrahydrobiopterin or a derivative thereof; tetrahydrobiopterins are enzyme cofactors that carry electrons in redox reactions." [GOC:BHF, GOC:mah, GOC:rl] +synonym: "BH4 binding" EXACT [] +synonym: "H4biopterin binding" EXACT [] +synonym: "sapropterin binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0034618 +name: arginine binding +namespace: molecular_function +def: "Binding to 2-amino-5-(carbamimidamido)pentanoic acid." [GOC:BHF, GOC:rl] +synonym: "aminopentanoic acid binding" RELATED [] +synonym: "Arg binding" EXACT [] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0034620 +name: cellular response to unfolded protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:mah] +comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER. +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0006986 ! response to unfolded protein +is_a: GO:0035967 ! cellular response to topologically incorrect protein + +[Term] +id: GO:0034624 +name: obsolete DNA recombinase assembly involved in gene conversion at mating-type locus +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA, involved in the conversion of the mating-type locus from one allele to another." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0034625 +name: fatty acid elongation, monounsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which one C-C double bond has been introduced." [GOC:mah] +is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid + +[Term] +id: GO:0034626 +name: fatty acid elongation, polyunsaturated fatty acid +namespace: biological_process +def: "Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced." [GOC:mah] +is_a: GO:0019368 ! fatty acid elongation, unsaturated fatty acid + +[Term] +id: GO:0034627 +name: 'de novo' NAD biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk, PMID:17161604] +synonym: "de novo NAD biosynthetic process" RELATED [] +is_a: GO:0009435 ! NAD biosynthetic process + +[Term] +id: GO:0034628 +name: 'de novo' NAD biosynthetic process from aspartate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:imk] +synonym: "de novo NAD biosynthetic process from aspartate" RELATED [] +is_a: GO:0019355 ! nicotinamide nucleotide biosynthetic process from aspartate +is_a: GO:0034627 ! 'de novo' NAD biosynthetic process + +[Term] +id: GO:0034630 +name: RITS complex localization +namespace: biological_process +def: "Any process in which a RITS complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of RITS complex localization" EXACT [] +synonym: "RITS complex localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0034631 +name: microtubule anchoring at spindle pole body +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116] +synonym: "attachment of spindle microtubules to SPB" EXACT [] +synonym: "attachment of spindle microtubules to spindle pole body" EXACT [] +synonym: "microtubule anchoring at SPB" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center +relationship: part_of GO:0007051 ! spindle organization + +[Term] +id: GO:0034632 +name: retinol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] +synonym: "retinol transporter activity" RELATED [] +synonym: "vitamin A1 transporter activity" EXACT [] +xref: Reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport" +xref: Reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol" +xref: Reactome:R-HSA-2466802 "Defective ABCA4 does not transport NRPE from disc membranes" +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:0090482 ! vitamin transmembrane transporter activity + +[Term] +id: GO:0034633 +name: retinol transport +namespace: biological_process +def: "The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah, GOC:vk] +synonym: "vitamin A1 transport" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046865 ! terpenoid transport + +[Term] +id: GO:0034634 +name: glutathione transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other." [GOC:mah] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042937 ! tripeptide transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0034635 +name: glutathione transport +namespace: biological_process +def: "The directed movement of glutathione, the tripeptide glutamylcysteinylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0042939 ! tripeptide transport +is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0034637 +name: cellular carbohydrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0034638 +name: phosphatidylcholine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:jp] +synonym: "phosphatidylcholine breakdown" EXACT [] +synonym: "phosphatidylcholine catabolism" EXACT [] +synonym: "phosphatidylcholine degradation" EXACT [] +is_a: GO:0046470 ! phosphatidylcholine metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0034639 +name: L-amino acid efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] +synonym: "L-amino acid efflux permease activity" EXACT [] +synonym: "L-amino acid export transporter activity" EXACT [] +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0034640 +name: establishment of mitochondrion localization by microtubule attachment +namespace: biological_process +def: "The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization." [GOC:mah, PMID:12972644] +synonym: "establishment of mitochondrion localisation by microtubule attachment" EXACT [GOC:mah] +synonym: "mitochondrial localization by microtubule attachment" EXACT [] +synonym: "mitochondrial migration by microtubule attachment" EXACT [] +synonym: "mitochondrion migration by microtubule attachment" EXACT [] +is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated +is_a: GO:0099098 ! microtubule polymerization based movement + +[Term] +id: GO:0034641 +name: cellular nitrogen compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] +subset: goslim_chembl +synonym: "cellular nitrogen compound metabolism" EXACT [] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0034642 +name: mitochondrion migration along actin filament +namespace: biological_process +def: "The directed movement of a mitochondrion along a microfilament, mediated by motor proteins." [GOC:mah, PMID:15979253, PMID:16306220] +synonym: "mitochondrial migration along actin filament" EXACT [GOC:dph, GOC:tb] +synonym: "mitochondrial migration along microfilament" EXACT [] +synonym: "mitochondrial migration, actin-mediated" EXACT [] +synonym: "mitochondrion migration along microfilament" EXACT [] +synonym: "mitochondrion transport along actin filament" EXACT [] +is_a: GO:0030048 ! actin filament-based movement +is_a: GO:0051654 ! establishment of mitochondrion localization +is_a: GO:0099515 ! actin filament-based transport + +[Term] +id: GO:0034643 +name: establishment of mitochondrion localization, microtubule-mediated +namespace: biological_process +def: "The directed movement of the mitochondrion to a specific location, by a process involving microtubules." [GOC:mah, PMID:12972644, PMID:15979253, PMID:16306220] +synonym: "establishment of mitochondrion localisation, microtubule-mediated" EXACT [GOC:mah] +synonym: "microtubule-mediated mitochondrion localization" EXACT [] +synonym: "mitochondrial localization, microtubule-mediated" EXACT [] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0051654 ! establishment of mitochondrion localization + +[Term] +id: GO:0034644 +name: cellular response to UV +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] +synonym: "cellular response to ultraviolet light stimulus" EXACT [] +synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] +synonym: "cellular response to UV light stimulus" EXACT [] +synonym: "cellular response to UV radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV +is_a: GO:0071482 ! cellular response to light stimulus + +[Term] +id: GO:0034645 +name: cellular macromolecule biosynthetic process +namespace: biological_process +alt_id: GO:0034961 +def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [GOC:mah] +synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] +synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] +synonym: "cellular macromolecule formation" EXACT [GOC:mah] +synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0034646 +name: organelle-enclosing lipid monolayer +namespace: cellular_component +def: "A lipid monolayer that surrounds and encloses an organelle." [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0034647 +name: histone H3-tri/di/monomethyl-lysine-4 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:17550896, PMID:22473470] +synonym: "H3K4me3 demethylase activity" RELATED [] +synonym: "histone demethylase activity (H3-K4-me3 specific)" EXACT [] +synonym: "histone demethylase activity (H3-trimethyl-K4 specific)" EXACT [] +synonym: "histone H3-K4me2 demethylase activity" BROAD [] +synonym: "histone H3-K4me3 demethylase activity" RELATED [] +synonym: "histone H3K4me2 demethylase activity" BROAD [] +xref: EC:1.14.11.67 +xref: RHEA:60208 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032453 ! histone H3-methyl-lysine-4 demethylase activity + +[Term] +id: GO:0034648 +name: obsolete histone demethylase activity (H3-dimethyl-K4 specific) +namespace: molecular_function +def: "OBSOLETE. Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:17550896] +comment: This term was obsoleted to align with RHEA and EC: this is a sub-reaction both in RHEA:60208 and EC:1.14.11.67. +synonym: "histone demethylase activity (H3-K4-me2 specific)" EXACT [] +is_obsolete: true +consider: GO:0034647 +consider: GO:0140682 + +[Term] +id: GO:0034649 +name: obsolete histone demethylase activity (H3-monomethyl-K4 specific) +namespace: molecular_function +def: "OBSOLETE. Catalysis of the removal of a methyl group from monomethylated lysine at position 4 of the histone H3 protein." [GOC:mah, PMID:16223729] +comment: This term was obsoleted to align with RHEA and EC: this is a sub-reaction both in RHEA:60208 and EC:1.14.11.67. +synonym: "histone demethylase activity (H3-K4-me1 specific)" EXACT [] +is_obsolete: true +consider: GO:0034647 +consider: GO:0140682 + +[Term] +id: GO:0034650 +name: cortisol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl] +synonym: "cortisol metabolism" EXACT [] +is_a: GO:0008211 ! glucocorticoid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:0034651 +name: cortisol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties." [GOC:BHF, GOC:mah, GOC:rl] +synonym: "cortisol anabolism" NARROW [] +synonym: "cortisol biosynthesis" EXACT [] +synonym: "cortisol formation" EXACT [] +synonym: "cortisol synthesis" EXACT [] +is_a: GO:0006704 ! glucocorticoid biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0034650 ! cortisol metabolic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:0034652 +name: extrachromosomal circular DNA localization involved in cell aging +namespace: biological_process +def: "A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging." [GOC:dph, GOC:jp, GOC:tb, PMID:18660802] +comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. +synonym: "extrachromosomal circular DNA localisation involved in cell aging" EXACT [GOC:mah] +synonym: "extrachromosomal circular DNA localization during cell ageing" EXACT [] +synonym: "extrachromosomal circular DNA localization during cell aging" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging + +[Term] +id: GO:0034653 +name: retinoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A." [GOC:BHF, GOC:mah] +synonym: "retinoic acid breakdown" EXACT [] +synonym: "retinoic acid catabolism" EXACT [] +synonym: "retinoic acid degradation" EXACT [] +synonym: "vitamin A1 acid catabolic process" EXACT [] +is_a: GO:0016103 ! diterpenoid catabolic process +is_a: GO:0042363 ! fat-soluble vitamin catabolic process +is_a: GO:0042573 ! retinoic acid metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0034654 +name: nucleobase-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0034655 +name: nucleobase-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] +subset: goslim_chembl +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] +synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0034656 +name: nucleobase-containing small molecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:mah] +synonym: "nucleobase, nucleoside and nucleotide breakdown" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide catabolism" EXACT [] +synonym: "nucleobase, nucleoside and nucleotide degradation" EXACT [] +is_a: GO:0034655 ! nucleobase-containing compound catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process + +[Term] +id: GO:0034657 +name: GID complex +namespace: cellular_component +def: "A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p." [PMID:12686616, PMID:18508925] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0034658 +name: isopropylmalate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of isopropylmalate from one side of a membrane to the other." [GOC:mah] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity + +[Term] +id: GO:0034659 +name: isopropylmalate transport +namespace: biological_process +def: "The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0034660 +name: ncRNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah] +synonym: "ncRNA metabolism" EXACT [] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0034661 +name: ncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs)." [GOC:rb, PMID:18591258] +synonym: "ncRNA breakdown" EXACT [] +synonym: "ncRNA catabolism" EXACT [] +synonym: "ncRNA degradation" EXACT [] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0034662 +name: CFTR-NHERF-ezrin complex +namespace: cellular_component +def: "A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity." [PMID:16129695, PMID:16798722, PMID:16926444] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0034663 +name: endoplasmic reticulum chaperone complex +namespace: cellular_component +def: "A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] +synonym: "endoplasmic reticulum network complex" RELATED [] +synonym: "ER chaperone complex" EXACT [] +synonym: "ER network complex" RELATED [] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0034664 +name: Ig heavy chain-bound endoplasmic reticulum chaperone complex +namespace: cellular_component +def: "A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1." [PMID:12475965] +synonym: "Ig heavy chain-bound ER chaperone complex" EXACT [] +synonym: "immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex" EXACT [] +is_a: GO:0101031 ! chaperone complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0034665 +name: integrin alpha1-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha1 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha1-beta1 integrin complex" EXACT [] +synonym: "ITGA1-ITGB1 complex" NARROW [] +synonym: "VLA-1 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034666 +name: integrin alpha2-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha2 subunit and one beta1 subunit." [PMID:12297042] +synonym: "ITGA2-ITGB1 complex" NARROW [CORUM:2432] +synonym: "VLA-2 complex" EXACT [PMID:3546305] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034667 +name: integrin alpha3-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha3 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha3-beta1 integrin complex" EXACT [] +synonym: "ITGA3-ITGB1 complex" NARROW [CORUM:2406] +synonym: "VLA-3 complex" EXACT [PMID:3546305] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034668 +name: integrin alpha4-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha4 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha4-beta1 integrin complex" EXACT [] +synonym: "ITGA4-ITGB1 complex" NARROW [] +synonym: "VLA-4 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034669 +name: integrin alpha4-beta7 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha4 subunit and one beta7 subunit." [PMID:12297042] +synonym: "alpha4-beta7 integrin complex" EXACT [] +synonym: "ITGA4-ITGB7 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034670 +name: chemotaxis to arachidonic acid +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of arachidonic acid." [GOC:go_curators, PMID:18202452] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0034671 +name: retinoic acid receptor signaling pathway involved in pronephros anterior/posterior pattern specification +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the pronephros." [GOC:mh] +synonym: "retinoic acid receptor signaling pathway involved in pronephric kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] +synonym: "retinoic acid receptor signalling pathway involved in pronephros anterior-posterior patterning" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0034672 ! anterior/posterior pattern specification involved in pronephros development + +[Term] +id: GO:0034672 +name: anterior/posterior pattern specification involved in pronephros development +namespace: biological_process +def: "The developmental process that results in the creation of defined areas or spaces within the pronephros along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mah] +synonym: "anterior/posterior pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0039017 ! pattern specification involved in pronephros development +is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development + +[Term] +id: GO:0034673 +name: inhibin-betaglycan-ActRII complex +namespace: cellular_component +def: "A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B." [GOC:BHF, PMID:10746731] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0034674 +name: integrin alpha5-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha5 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha5-beta1 integrin complex" EXACT [] +synonym: "ITGA5-ITGB1 complex" NARROW [] +synonym: "VLA-5 complex" EXACT [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034675 +name: integrin alpha6-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha6 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha6-beta1 integrin complex" EXACT [] +synonym: "ITGA6-ITGB1 complex" NARROW [CORUM:2413] +synonym: "VLA-6 complex" EXACT [PMID:2649503] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034676 +name: integrin alpha6-beta4 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha6 subunit and one beta4 subunit." [PMID:12297042] +synonym: "alpha6-beta4 integrin complex" EXACT [] +synonym: "ITGA6-ITGB4 complex" NARROW [CORUM:2323] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034677 +name: integrin alpha7-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha7 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha7-beta1 integrin complex" EXACT [] +synonym: "ITGA7-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034678 +name: integrin alpha8-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha8 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha8-beta1 integrin complex" EXACT [] +synonym: "ITGA8-ITGB1 complex" NARROW [CORUM:2439] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034679 +name: integrin alpha9-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha9 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha9-beta1 integrin complex" EXACT [] +synonym: "ITGA9-ITGB1 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034680 +name: integrin alpha10-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha10 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha10-beta1 integrin complex" EXACT [] +synonym: "ITGA10-ITGB1 complex" NARROW [CORUM:3057] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034681 +name: integrin alpha11-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alpha11 subunit and one beta1 subunit." [PMID:12297042] +synonym: "alpha11-beta1 integrin complex" EXACT [] +synonym: "ITGA11-ITGB1 complex" NARROW [CORUM:3058] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034682 +name: integrin alphav-beta1 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta1 subunit." [PMID:12297042] +synonym: "alphav-beta1 integrin complex" EXACT [] +synonym: "ITGAV-ITGB1 complex" NARROW [CORUM:2436] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034683 +name: integrin alphav-beta3 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta3 subunit." [PMID:12297042] +synonym: "alphav-beta3 integrin complex" EXACT [] +synonym: "ITGAV-ITGB3 complex" NARROW [CORUM:2816] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034684 +name: integrin alphav-beta5 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta5 subunit." [PMID:12297042] +synonym: "alphav-beta5 integrin complex" EXACT [] +synonym: "ITGAV-ITGB5 complex" NARROW [CORUM:2350] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034685 +name: integrin alphav-beta6 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta6 subunit." [PMID:12297042] +synonym: "alphav-beta6 integrin complex" EXACT [] +synonym: "ITGAV-ITGB6 complex" NARROW [CORUM:2354] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034686 +name: integrin alphav-beta8 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphav subunit and one beta8 subunit." [PMID:12297042] +synonym: "alphav-beta8 integrin complex" EXACT [] +synonym: "ITGAV-ITGB8 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034687 +name: integrin alphaL-beta2 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaL subunit and one beta2 subunit." [PMID:12297042] +synonym: "alphaL-beta2 integrin complex" EXACT [] +synonym: "Itgal-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034688 +name: integrin alphaM-beta2 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaM subunit and one beta2 subunit." [PMID:12297042] +synonym: "alphaM-beta2 integrin complex" EXACT [] +synonym: "Itgam-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034689 +name: integrin alphaX-beta2 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaX subunit and one beta2 subunit." [PMID:12297042] +synonym: "alphaX-beta2 integrin complex" EXACT [] +synonym: "Itgax-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034690 +name: integrin alphaD-beta2 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaD subunit and one beta2 subunit." [PMID:12297042] +synonym: "alphaD-beta2 integrin complex" EXACT [] +synonym: "Itgad-Itgb2 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034691 +name: integrin alphaE-beta7 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaE subunit and one beta7 subunit." [PMID:12297042] +synonym: "Itgae-Itgb7 complex" NARROW [] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0034692 +name: E.F.G complex +namespace: cellular_component +def: "A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex." [PMID:8641291] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034693 +name: U11/U12 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins." [GOC:mah, PMID:15146077] +synonym: "18S U11/U12 snRNP" NARROW [] +synonym: "snRNP U11/U12" EXACT [GOC:mah] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0034694 +name: response to prostaglandin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:BHF, GOC:vk] +synonym: "response to prostaglandin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0034695 +name: response to prostaglandin E +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:BHF, GOC:vk] +synonym: "response to prostaglandin E stimulus" EXACT [GOC:dos] +is_a: GO:0034694 ! response to prostaglandin +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0034696 +name: response to prostaglandin F +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:BHF, GOC:vk] +synonym: "response to prostaglandin F stimulus" EXACT [GOC:dos] +is_a: GO:0034694 ! response to prostaglandin + +[Term] +id: GO:0034697 +name: response to prostaglandin I +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:BHF, GOC:vk] +synonym: "response to prostaglandin I stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0034694 ! response to prostaglandin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0034698 +name: response to gonadotropin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:BHF, GOC:vk] +synonym: "response to gonadotropin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0034699 +name: response to luteinizing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:BHF, GOC:vk] +synonym: "response to luteinizing hormone stimulus" EXACT [GOC:dos] +is_a: GO:0034698 ! response to gonadotropin +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0034700 +name: allulose 6-phosphate 3-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate." [GOC:imk] +xref: MetaCyc:RXN0-304 +xref: RHEA:28426 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0034701 +name: tripeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a tripeptide." [GOC:mah] +xref: EC:3.4.13.- +xref: MetaCyc:3.4.11.4-RXN +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0034702 +name: ion channel complex +namespace: cellular_component +def: "A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:mah, ISBN:071673706X] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:0034703 +name: cation channel complex +namespace: cellular_component +def: "An ion channel complex through which cations pass." [GOC:mah] +is_a: GO:0034702 ! ion channel complex + +[Term] +id: GO:0034704 +name: calcium channel complex +namespace: cellular_component +def: "An ion channel complex through which calcium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034705 +name: potassium channel complex +namespace: cellular_component +def: "An ion channel complex through which potassium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034706 +name: sodium channel complex +namespace: cellular_component +def: "An ion channel complex through which sodium ions pass." [GOC:mah] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0034707 +name: chloride channel complex +namespace: cellular_component +def: "An ion channel complex through which chloride ions pass." [GOC:mah] +is_a: GO:0034702 ! ion channel complex + +[Term] +id: GO:0034708 +name: methyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses methyltransferase activity." [GOC:mah] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0034709 +name: methylosome +namespace: cellular_component +def: "A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains." [PMID:11713266, PMID:11756452] +synonym: "20S methylosome" EXACT [] +synonym: "20S methyltransferase complex" EXACT [] +is_a: GO:0034708 ! methyltransferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034710 +name: inhibin complex binding +namespace: molecular_function +def: "Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit." [GOC:BHF, GOC:mah] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0034711 +name: inhibin binding +namespace: molecular_function +alt_id: GO:0034712 +alt_id: GO:0048186 +alt_id: GO:0048187 +def: "Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers." [GOC:BHF, GOC:mah] +synonym: "inhibin alpha binding" NARROW [] +synonym: "inhibin beta-A binding" NARROW [] +synonym: "inhibin beta-B binding" NARROW [] +synonym: "inhibin monomer binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0034713 +name: type I transforming growth factor beta receptor binding +namespace: molecular_function +alt_id: GO:0005103 +alt_id: GO:0005116 +alt_id: GO:0005120 +def: "Binding to a type I transforming growth factor beta receptor." [GOC:BHF, GOC:mah] +synonym: "babo binding" NARROW [] +synonym: "babo ligand" NARROW [] +synonym: "baboon binding" NARROW [] +synonym: "baboon ligand" NARROW [] +synonym: "baboon receptor ligand" NARROW [] +synonym: "sax binding" NARROW [] +synonym: "sax ligand" NARROW [] +synonym: "saxophone binding" NARROW [] +synonym: "saxophone ligand" NARROW [] +synonym: "TGF-beta type I binding" EXACT [] +synonym: "thickveins binding" NARROW [] +synonym: "thickveins ligand" NARROW [] +synonym: "tkv binding" NARROW [] +synonym: "tkv ligand" NARROW [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta receptor type I binding" EXACT [] +synonym: "type I TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0034714 +name: type III transforming growth factor beta receptor binding +namespace: molecular_function +def: "Binding to a type III transforming growth factor beta receptor." [GOC:BHF, GOC:mah] +synonym: "betaglycan binding" RELATED [] +synonym: "TGF-beta type III binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] +synonym: "transforming growth factor beta receptor type III binding" EXACT [] +synonym: "type IIII TGF-beta binding" EXACT [] +is_a: GO:0005160 ! transforming growth factor beta receptor binding + +[Term] +id: GO:0034715 +name: pICln-Sm protein complex +namespace: cellular_component +def: "A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG." [GOC:mah, PMID:11713266] +synonym: "6S pICln complex" EXACT [] +is_a: GO:0120114 ! Sm-like protein family complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034716 +name: Gemin3-Gemin4-Gemin5 complex +namespace: cellular_component +def: "A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly." [GOC:mah, PMID:17640873] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0034717 +name: Gemin6-Gemin7-unrip complex +namespace: cellular_component +def: "A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly." [GOC:mah, PMID:17640873] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0034718 +name: SMN-Gemin2 complex +namespace: cellular_component +def: "A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex." [GOC:mah, PMID:17640873] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +is_a: GO:0120114 ! Sm-like protein family complex + +[Term] +id: GO:0034719 +name: SMN-Sm protein complex +namespace: cellular_component +def: "A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm." [GOC:vw, PMID:11522829, PMID:17401408] +comment: Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797. +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0120114 ! Sm-like protein family complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034720 +name: histone H3-K4 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone." [GOC:mah] +synonym: "H3K4 demethylation (me1 me2 and me3)" RELATED [] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0034721 +name: histone H3-K4 demethylation, trimethyl-H3-K4-specific +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone." [GOC:mah] +synonym: "H3K4 demethylation (me3)" EXACT [] +synonym: "histone H3-K4 tridemethylation" RELATED [] +is_a: GO:0034720 ! histone H3-K4 demethylation + +[Term] +id: GO:0034722 +name: gamma-glutamyl-peptidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a gamma-linked glutamate bond." [EC:3.4.19.9, MEROPS_fam:C26] +synonym: "gamma-glutamyl hydrolase activity" RELATED [EC:3.4.19.9] +xref: EC:3.4.19.9 +xref: MetaCyc:3.4.19.9-RXN +xref: RHEA:56784 +is_a: GO:0008234 ! cysteine-type peptidase activity +is_a: GO:0008242 ! omega peptidase activity + +[Term] +id: GO:0034723 +name: DNA replication-dependent chromatin organization +namespace: biological_process +def: "The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] +synonym: "DNA replication-dependent nucleosome organisation" EXACT [] +synonym: "DNA replication-dependent nucleosome organization" EXACT [] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0034724 +name: DNA replication-independent chromatin organization +namespace: biological_process +def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629] +synonym: "DNA replication-independent nucleosome organisation" EXACT [] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0034725 +name: obsolete DNA replication-dependent nucleosome disassembly +namespace: biological_process +def: "OBSOLETE. The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah, PMID:17510629] +comment: This term was obsoleted because it did not describe a different process from that described by its parent. +synonym: "DNA replication-dependent chromatin disassembly" EXACT [] +is_obsolete: true +consider: GO:0006337 + +[Term] +id: GO:0034726 +name: obsolete DNA replication-independent nucleosome disassembly +namespace: biological_process +def: "OBSOLETE. The controlled disassembly of chromatin outside the context of DNA replication." [GOC:mah, PMID:17510629] +comment: This term was obsoleted because it did not describe a different process from that described by its parent. +synonym: "DNA replication-independent chromatin disassembly" RELATED [] +is_obsolete: true + +[Term] +id: GO:0034727 +name: piecemeal microautophagy of the nucleus +namespace: biological_process +def: "Degradation of a cell nucleus by lysosomal microautophagy." [GOC:autophagy, GOC:jp, PMID:18701704] +synonym: "PMN" EXACT [] +is_a: GO:0016237 ! lysosomal microautophagy +is_a: GO:0044804 ! autophagy of nucleus + +[Term] +id: GO:0034728 +name: nucleosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah] +synonym: "nucleosome organisation" EXACT [] +is_a: GO:0006338 ! chromatin remodeling +is_a: GO:0071824 ! protein-DNA complex subunit organization + +[Term] +id: GO:0034729 +name: histone H3-K79 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone." [GOC:se] +synonym: "histone H3 K79 methylation" EXACT [] +synonym: "histone H3K79me" EXACT [] +synonym: "histone lysine H3 K79 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0034730 +name: SmD-containing SMN-Sm protein complex +namespace: cellular_component +def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex." [PMID:12975319, PMID:17401408] +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0034719 ! SMN-Sm protein complex + +[Term] +id: GO:0034731 +name: Lsm-containing SMN-Sm protein complex +namespace: cellular_component +def: "An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA." [PMID:12975319, PMID:17401408] +synonym: "SMN-containing protein complex" BROAD [] +is_a: GO:0034719 ! SMN-Sm protein complex + +[Term] +id: GO:0034732 +name: transcription factor TFIIIB-alpha complex +namespace: cellular_component +def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." [PMID:11433012] +is_a: GO:0000126 ! transcription factor TFIIIB complex + +[Term] +id: GO:0034733 +name: transcription factor TFIIIB-beta complex +namespace: cellular_component +def: "A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters." [PMID:11433012] +comment: Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans. +is_a: GO:0000126 ! transcription factor TFIIIB complex + +[Term] +id: GO:0034734 +name: transcription factor TFIIIC1 complex +namespace: cellular_component +def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity." [GOC:mah, PMID:11433012, PMID:15096501] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex +relationship: part_of GO:0000127 ! transcription factor TFIIIC complex + +[Term] +id: GO:0034735 +name: transcription factor TFIIIC2 complex +namespace: cellular_component +def: "A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter." [GOC:mah, PMID:11433012] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex +relationship: part_of GO:0000127 ! transcription factor TFIIIC complex + +[Term] +id: GO:0034736 +name: cholesterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA." [EC:2.3.1.26, RHEA:17729] +synonym: "ACAT activity" BROAD [EC:2.3.1.26] +synonym: "acyl coenzyme A-cholesterol-O-acyltransferase activity" RELATED [EC:2.3.1.26] +synonym: "acyl-CoA:cholesterol acyltransferase activity" RELATED [EC:2.3.1.26] +synonym: "acyl-CoA:cholesterol O-acyltransferase activity" RELATED [EC:2.3.1.26] +synonym: "acylcoenzyme A:cholesterol O-acyltransferase activity" EXACT [] +synonym: "cholesterol acyltransferase activity" BROAD [EC:2.3.1.26] +synonym: "cholesterol ester synthetase activity" RELATED [EC:2.3.1.26] +synonym: "cholesteryl ester synthetase activity" RELATED [EC:2.3.1.26] +xref: EC:2.3.1.26 +xref: KEGG_REACTION:R01461 +xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-8876696 "SOAT1,2 transfer acyl group to CHOL forming CHEST" +xref: RHEA:17729 +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034737 +name: ergosterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester." [GOC:mah] +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034738 +name: lanosterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester." [GOC:mah] +is_a: GO:0004772 ! sterol O-acyltransferase activity + +[Term] +id: GO:0034739 +name: histone deacetylase activity (H4-K16 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:vw, PMID:28450737] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0034740 +name: TFIIIC-TOP1-SUB1 complex +namespace: cellular_component +def: "A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III." [PMID:9660958] +synonym: "TFIIIC-Topoisomerase 1-PC4 complex" EXACT [] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex + +[Term] +id: GO:0034741 +name: APC-tubulin-IQGAP1 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization." [PMID:17126424] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "60S APC complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034743 +name: APC-IQGAP complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034744 +name: APC-IQGAP1-Cdc42 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034745 +name: APC-IQGAP1-Rac1 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034746 +name: APC-IQGAP1-CLIP-170 complex +namespace: cellular_component +def: "A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration." [PMID:15572129] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0034748 +name: Par3-APC-KIF3A complex +namespace: cellular_component +def: "A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity." [PMID:15556865] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034749 +name: Scrib-APC complex +namespace: cellular_component +def: "A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation." [PMID:16611247] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "hScrib-APC complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034750 +name: Scrib-APC-beta-catenin complex +namespace: cellular_component +def: "A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation." [PMID:16611247] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "hScrib-APC-beta-catenin complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034751 +name: aryl hydrocarbon receptor complex +namespace: cellular_component +def: "A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR." [GOC:mah, PMID:7598497] +synonym: "AhR complex" EXACT [] +synonym: "AHRC" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0034752 +name: cytosolic aryl hydrocarbon receptor complex +namespace: cellular_component +def: "An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." [PMID:7598497, PMID:8937476, PMID:9447995] +synonym: "9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex" RELATED [] +synonym: "cytosolic AhR complex" EXACT [] +synonym: "cytosolic AHRC" EXACT [] +is_a: GO:0034751 ! aryl hydrocarbon receptor complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0034753 +name: nuclear aryl hydrocarbon receptor complex +namespace: cellular_component +def: "An aryl hydrocarbon receptor (AhR) complex found in the nucleus; ; consists of ligand-bound AhR and the aryl hydrocarbon receptor nuclear translocator (ARNT)." [PMID:7598497] +synonym: "6S-nuclear aryl hydrocarbon (Ah) receptor ligand-activated complex" RELATED [] +synonym: "nuclear AhR complex" EXACT [] +synonym: "nuclear AHRC" EXACT [] +is_a: GO:0034751 ! aryl hydrocarbon receptor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034754 +name: cellular hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells." [GOC:mah] +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0034755 +name: iron ion transmembrane transport +namespace: biological_process +alt_id: GO:0000040 +alt_id: GO:0006827 +alt_id: GO:0061839 +alt_id: GO:1903874 +def: "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah, PMID:11390404] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ferrous ion transmembrane transport" NARROW [] +synonym: "ferrous iron transmembrane transport" NARROW [] +synonym: "high affinity ferrous ion transmembrane transport" NARROW [] +synonym: "high affinity iron ion transport" NARROW [] +synonym: "high-affinity ferrous ion transmembrane transport" NARROW [] +synonym: "high-affinity iron ion transmembrane transport" NARROW [] +synonym: "high-affinity iron ion transport" NARROW [] +synonym: "iron ion membrane transport" EXACT [] +synonym: "iron(2+) transmembrane transport" NARROW [] +synonym: "low affinity iron ion transport" NARROW [] +synonym: "low-affinity iron ion transmembrane transport" NARROW [] +synonym: "low-affinity iron ion transport" NARROW [] +synonym: "transmembrane iron transport" EXACT [] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0034756 +name: regulation of iron ion transport +namespace: biological_process +alt_id: GO:1900390 +def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "regulation of Fe transport" EXACT [] +synonym: "regulation of iron import" NARROW [GOC:TermGenie] +synonym: "regulation of iron ion import" NARROW [] +synonym: "regulation of iron transport" EXACT [] +is_a: GO:0010959 ! regulation of metal ion transport +relationship: regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034757 +name: negative regulation of iron ion transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of iron ion transport" EXACT [] +synonym: "down-regulation of iron ion transport" EXACT [] +synonym: "downregulation of iron ion transport" EXACT [] +synonym: "inhibition of iron ion transport" NARROW [] +synonym: "negative regulation of iron transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034758 +name: positive regulation of iron ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of iron ion transport" NARROW [] +synonym: "positive regulation of iron transport" EXACT [] +synonym: "stimulation of iron ion transport" NARROW [] +synonym: "up regulation of iron ion transport" EXACT [] +synonym: "up-regulation of iron ion transport" EXACT [] +synonym: "upregulation of iron ion transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006826 ! iron ion transport + +[Term] +id: GO:0034759 +name: regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "regulation of iron ion membrane transport" EXACT [] +synonym: "regulation of transmembrane Fe transport" EXACT [] +synonym: "regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0034760 +name: negative regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "down regulation of transmembrane iron ion transport" EXACT [] +synonym: "down-regulation of transmembrane iron ion transport" EXACT [] +synonym: "downregulation of transmembrane iron ion transport" EXACT [] +synonym: "inhibition of transmembrane iron ion transport" NARROW [] +synonym: "negative regulation of iron ion membrane transport" EXACT [] +synonym: "negative regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of transmembrane iron transport" EXACT [] +is_a: GO:0034757 ! negative regulation of iron ion transport +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0034761 +name: positive regulation of iron ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "activation of transmembrane iron ion transport" NARROW [] +synonym: "positive regulation of iron ion membrane transport" EXACT [] +synonym: "positive regulation of transmembrane iron ion transport" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of transmembrane iron transport" EXACT [] +synonym: "stimulation of transmembrane iron ion transport" NARROW [] +synonym: "up regulation of transmembrane iron ion transport" EXACT [] +synonym: "up-regulation of transmembrane iron ion transport" EXACT [] +synonym: "upregulation of transmembrane iron ion transport" EXACT [] +is_a: GO:0034758 ! positive regulation of iron ion transport +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0034762 +name: regulation of transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +synonym: "regulation of membrane transport" EXACT [] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034763 +name: negative regulation of transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane transport" EXACT [] +synonym: "down-regulation of transmembrane transport" EXACT [] +synonym: "downregulation of transmembrane transport" EXACT [] +synonym: "inhibition of transmembrane transport" NARROW [] +synonym: "negative regulation of membrane transport" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034764 +name: positive regulation of transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane transport" NARROW [] +synonym: "positive regulation of membrane transport" EXACT [] +synonym: "stimulation of transmembrane transport" NARROW [] +synonym: "up regulation of transmembrane transport" EXACT [] +synonym: "up-regulation of transmembrane transport" EXACT [] +synonym: "upregulation of transmembrane transport" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0055085 ! transmembrane transport + +[Term] +id: GO:0034765 +name: regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "regulation of ion membrane transport" EXACT [] +synonym: "regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0034766 +name: negative regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "down regulation of transmembrane ion transport" EXACT [] +synonym: "down-regulation of transmembrane ion transport" EXACT [] +synonym: "downregulation of transmembrane ion transport" EXACT [] +synonym: "inhibition of transmembrane ion transport" NARROW [] +synonym: "negative regulation of ion membrane transport" EXACT [] +synonym: "negative regulation of transmembrane ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0034767 +name: positive regulation of ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other." [GOC:mah] +synonym: "activation of transmembrane ion transport" NARROW [] +synonym: "positive regulation of ion membrane transport" EXACT [] +synonym: "positive regulation of transmembrane ion transport" EXACT [] +synonym: "stimulation of transmembrane ion transport" NARROW [] +synonym: "up regulation of transmembrane ion transport" EXACT [] +synonym: "up-regulation of transmembrane ion transport" EXACT [] +synonym: "upregulation of transmembrane ion transport" EXACT [] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0034768 +name: (E)-beta-ocimene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate." [EC:4.2.3.106, PMID:12624761] +xref: EC:4.2.3.106 +xref: MetaCyc:RXN-5109 +xref: RHEA:32691 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0034769 +name: basement membrane disassembly +namespace: biological_process +alt_id: GO:0060881 +def: "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion." [GOC:sart, PMID:17301221] +comment: Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. +synonym: "basal lamina disassembly" RELATED [] +is_a: GO:0022617 ! extracellular matrix disassembly +is_a: GO:0071711 ! basement membrane organization + +[Term] +id: GO:0034770 +name: histone H4-K20 methylation +namespace: biological_process +def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H4 K20 methylation" EXACT [] +synonym: "histone H4K20me" EXACT [] +synonym: "histone lysine H4 K20 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0034771 +name: histone H4-K20 monomethylation +namespace: biological_process +def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H4 K20 monomethylation" EXACT [] +synonym: "histone lysine H4 K20 monomethylation" EXACT [] +is_a: GO:0018026 ! peptidyl-lysine monomethylation +is_a: GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0034772 +name: histone H4-K20 dimethylation +namespace: biological_process +def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H4 K20 dimethylation" EXACT [] +synonym: "histone lysine H4 K20 dimethylation" EXACT [] +is_a: GO:0018027 ! peptidyl-lysine dimethylation +is_a: GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0034773 +name: histone H4-K20 trimethylation +namespace: biological_process +def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah] +synonym: "histone H4 K20 trimethylation" EXACT [] +synonym: "histone lysine H4 K20 trimethylation" EXACT [] +is_a: GO:0018023 ! peptidyl-lysine trimethylation +is_a: GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0034774 +name: secretory granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a secretory granule." [GOC:rph] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0030141 ! secretory granule + +[Term] +id: GO:0034775 +name: glutathione transmembrane transport +namespace: biological_process +def: "A process in which glutathione is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "glutathione membrane transport" EXACT [] +synonym: "transmembrane glutathione transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034635 ! glutathione transport +is_a: GO:0035443 ! tripeptide transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0034776 +name: response to histamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:BHF, GOC:mah, GOC:vk] +synonym: "response to histamine stimulus" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0034777 +name: recycling endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a recycling endosome." [GOC:rph] +is_a: GO:0031904 ! endosome lumen +relationship: part_of GO:0055037 ! recycling endosome + +[Term] +id: GO:0034778 +name: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1003] +xref: UM-BBD_reactionID:r1003 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034779 +name: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA." [UM-BBD_reactionID:r1004] +xref: UM-BBD_reactionID:r1004 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034780 +name: glyphosate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-." [UM-BBD_reactionID:r0073] +xref: UM-BBD_reactionID:r0073 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034781 +name: N-cyclohexylformamide amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate." [UM-BBD_reactionID:r1030] +xref: UM-BBD_reactionID:r1030 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034782 +name: dimethylmalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2." [UM-BBD_reactionID:r1031] +xref: UM-BBD_reactionID:r1031 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034783 +name: pivalate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP." [UM-BBD_reactionID:r1032] +xref: UM-BBD_reactionID:r1032 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034784 +name: pivalyl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA." [UM-BBD_reactionID:r1033] +xref: EC:5.4.99.- +xref: UM-BBD_reactionID:r1033 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034785 +name: salicylate 5-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+." [UM-BBD_reactionID:r1034] +xref: EC:1.14.13.172 +xref: MetaCyc:RXN-10446 +xref: RHEA:35307 +xref: UM-BBD_reactionID:r1034 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034786 +name: 9-fluorenone-3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone." [UM-BBD_reactionID:r1039] +xref: UM-BBD_reactionID:r1039 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034787 +name: 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-." [UM-BBD_reactionID:r1040] +xref: UM-BBD_reactionID:r1040 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034788 +name: 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+." [UM-BBD_reactionID:r1041] +xref: UM-BBD_reactionID:r1041 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0034789 +name: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+." [UM-BBD_reactionID:r1042] +xref: UM-BBD_reactionID:r1042 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034790 +name: 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1043] +xref: UM-BBD_reactionID:r1043 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034791 +name: isobutylamine N-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O." [UM-BBD_reactionID:r1053] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r1053 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034792 +name: hypophosphite dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2." [UM-BBD_reactionID:r1058] +xref: UM-BBD_reactionID:r1058 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0034793 +name: cyclopropanecarboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-." [UM-BBD_reactionID:r1056] +xref: UM-BBD_reactionID:r1056 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034794 +name: cyclopropanecarboxyl-CoA decyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA." [UM-BBD_reactionID:r1057] +xref: EC:5.5.1.- +xref: UM-BBD_reactionID:r1057 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0034795 +name: cyclohexane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O." [UM-BBD_reactionID:r1059] +synonym: "butane monooxygenase activity" RELATED [] +synonym: "cyclohexane hydroxylase activity" EXACT [MetaCyc:RXN-8697] +xref: EC:1.14.15.- +xref: KEGG_REACTION:R06945 +xref: MetaCyc:RXN-8697 +xref: UM-BBD_reactionID:r1059 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034796 +name: adipate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-." [UM-BBD_reactionID:r1060] +xref: UM-BBD_reactionID:r1060 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034797 +name: fosfomycin 2-glutathione ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1073] +xref: UM-BBD_reactionID:r1073 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0034798 +name: fosfomycin 2-L-cysteine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid." [UM-BBD_reactionID:r1074] +xref: UM-BBD_reactionID:r1074 +is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds + +[Term] +id: GO:0034799 +name: dihydride TNP tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form)." [UM-BBD_reactionID:r1070] +xref: UM-BBD_reactionID:r1070 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0034800 +name: trinitrophenol dihydride denitratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP." [UM-BBD_reactionID:r1067] +synonym: "2,4,6-trinitrophenol dihydride denitratase activity" EXACT [] +synonym: "TNP dihydride denitratase activity" EXACT [] +xref: EC:1.7.99.- +xref: UM-BBD_reactionID:r1067 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0034801 +name: 2,4-dinitrocyclohexanone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate." [UM-BBD_reactionID:r1069] +xref: UM-BBD_reactionID:r1069 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034802 +name: branched-chain dodecylbenzene sulfonate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite." [UM-BBD_reactionID:r1079] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r1079 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034803 +name: 3-hydroxy-2-naphthoate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate." [UM-BBD_reactionID:r1104] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1104 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034804 +name: benzo(a)pyrene 11,12-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide." [UM-BBD_reactionID:r1119] +xref: UM-BBD_reactionID:r1119 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034805 +name: benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r1121] +xref: UM-BBD_reactionID:r1121 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034806 +name: benzo(a)pyrene 11,12-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol." [UM-BBD_reactionID:r1124] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1124 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034807 +name: 4,5-dihydroxybenzo(a)pyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene." [UM-BBD_reactionID:r1131] +xref: UM-BBD_reactionID:r1131 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034808 +name: benzo(a)pyrene 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol." [UM-BBD_reactionID:r1126] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1126 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034809 +name: benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2." [UM-BBD_reactionID:r1127] +xref: UM-BBD_reactionID:r1127 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034810 +name: 4,5-dihydroxybenzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate." [UM-BBD_reactionID:r1128] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1128 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034811 +name: benzo(a)pyrene 9,10-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." [UM-BBD_reactionID:r1132] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1132 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034812 +name: 9,10-dihydroxybenzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1134] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1134 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034813 +name: benzo(a)pyrene 7,8-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol." [UM-BBD_reactionID:1137] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1137 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034814 +name: 7,8-dihydroxy benzo(a)pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r1138] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1138 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034815 +name: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+." [UM-BBD_reactionID:r1135] +xref: EC:4.1.3.- +xref: UM-BBD_reactionID:r1135 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034816 +name: anthracene 9,10-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol." [UM-BBD_reactionID:r1141] +xref: UM-BBD_reactionID:r1141 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034817 +name: cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-." [UM-BBD_reactionID:r1144] +xref: UM-BBD_reactionID:r1144 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034818 +name: ADD 9alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin." [UM-BBD_reactionID:r1149] +xref: EC:1.14.15.- +xref: UM-BBD_reactionID:r1149 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034819 +name: 3-HSA hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O." [UM-BBD_reactionID:r1150] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r1150 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034820 +name: 4,9-DSHA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+." [UM-BBD_reactionID:r1152] +xref: UM-BBD_reactionID:r1152 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034821 +name: citronellol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+." [UM-BBD_reactionID:r1155] +xref: UM-BBD_reactionID:r1155 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034822 +name: citronellal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+." [UM-BBD_reactionID:r1156] +xref: UM-BBD_reactionID:r1156 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034823 +name: citronellyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1157] +xref: KEGG_REACTION:R08088 +xref: UM-BBD_reactionID:r1157 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034824 +name: citronellyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+." [UM-BBD_reactionID:r1159] +xref: UM-BBD_reactionID:r1159 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034825 +name: tetralin ring-hydroxylating dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+." [UM-BBD_reactionID:r1169] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r1169 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034826 +name: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." [UM-BBD_reactionID:r1170] +xref: UM-BBD_reactionID:r1170 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034827 +name: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+." [UM-BBD_reactionID:r1171] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1171 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034828 +name: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+." [UM-BBD_reactionID:r1172] +xref: UM-BBD_reactionID:r1172 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034829 +name: 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate." [UM-BBD_reactionID:r1172] +xref: UM-BBD_reactionID:r1172 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034830 +name: (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate." [UM-BBD_reactionID:r1174] +xref: EC:4.1.3.- +xref: UM-BBD_reactionID:r1174 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034831 +name: (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1176] +xref: UM-BBD_reactionID:r1176 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034832 +name: geranial dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+." [UM-BBD_reactionID:r1164] +xref: UM-BBD_reactionID:r1164 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034833 +name: geranylate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-." [UM-BBD_reactionID:r1165] +xref: UM-BBD_reactionID:r1165 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034834 +name: 2-mercaptobenzothiazole dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol." [UM-BBD_reactionID:r1177] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1177 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034835 +name: 2-mercaptobenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1178] +xref: EC:1.13.12.- +xref: UM-BBD_reactionID:r1178 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034836 +name: 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole." [UM-BBD_reactionID:r1181] +xref: EC:1.13.12.- +xref: UM-BBD_reactionID:r1181 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034837 +name: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-." [UM-BBD_reactionID:r1179] +xref: UM-BBD_reactionID:r1179 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034838 +name: menthone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+." [UM-BBD_reactionID:r1183] +xref: UM-BBD_reactionID:r1183 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034839 +name: menth-2-enone hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone." [UM-BBD_reactionID:r1184] +xref: UM-BBD_reactionID:r1184 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034840 +name: 3-hydroxymenthone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+." [UM-BBD_reactionID:r1185] +xref: UM-BBD_reactionID:r1185 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034841 +name: mentha-1,3-dione-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA." [UM-BBD_reactionID:r1186] +xref: UM-BBD_reactionID:r1186 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034842 +name: thiophene-2-carboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi." [UM-BBD_reactionID:r1234] +xref: UM-BBD_reactionID:r1234 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034843 +name: 2-oxoglutaryl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH." [UM-BBD_reactionID:r1238] +xref: UM-BBD_reactionID:r1238 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034844 +name: naphthyl-2-methyl-succinate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate." [UM-BBD_reactionID:r1256] +xref: UM-BBD_reactionID:r1256 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034845 +name: naphthyl-2-methyl-succinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1258] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r1258 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034846 +name: naphthyl-2-methylene-succinyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA." [UM-BBD_reactionID:r1259] +xref: UM-BBD_reactionID:r1259 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034847 +name: naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1260] +xref: UM-BBD_reactionID:r1260 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034848 +name: naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA." [UM-BBD_reactionID:r1261] +xref: UM-BBD_reactionID:r1261 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034849 +name: 2-naphthoate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH." [UM-BBD_reactionID:r1262] +xref: UM-BBD_reactionID:r1262 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0034850 +name: isooctane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol." [UM-BBD_reactionID:r1269] +xref: EC:1.13.12.- +xref: UM-BBD_reactionID:r1269 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034851 +name: 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r1274] +xref: UM-BBD_reactionID:r1274 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034852 +name: 4,4-dimethyl-3-oxopentanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1309] +xref: UM-BBD_reactionID:r1309 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0034853 +name: 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2." [UM-BBD_reactionID:r1278] +xref: UM-BBD_reactionID:r1278 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034854 +name: 4,4-dimethyl-3-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2." [UM-BBD_reactionID:r1280] +xref: UM-BBD_reactionID:r1280 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034855 +name: 4-AD 9alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O." [UM-BBD_reactionID:r1153] +xref: EC:1.14.15.- +xref: UM-BBD_reactionID:r1153 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034856 +name: 2-hydroxyhexa-2,4-dienoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate." [UM-BBD_reactionID:r1281] +xref: EC:4.2.1.132 +xref: RHEA:32535 +xref: UM-BBD_reactionID:r1281 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034857 +name: 2-(methylthio)benzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole." [UM-BBD_reactionID:r1287] +xref: UM-BBD_reactionID:r1287 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034858 +name: 2-hydroxybenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole." [UM-BBD_reactionID:r1291] +xref: UM-BBD_reactionID:r1291 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034859 +name: benzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole." [UM-BBD_reactionID:r1292] +xref: UM-BBD_reactionID:r1292 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034860 +name: 2-mercaptobenzothiazole desulfurase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor." [UM-BBD_reactionID:r1288] +xref: EC:4.4.1.- +xref: UM-BBD_reactionID:r1288 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0034861 +name: benzothiazole-2-sulfonate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-." [UM-BBD_reactionID:r1290] +xref: EC:3.13.1.- +xref: UM-BBD_reactionID:r1290 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0034862 +name: 2,6-dihydroxybenzothiazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole." [UM-BBD_reactionID:r1294] +xref: UM-BBD_reactionID:r1294 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034863 +name: 2,4,4-trimethyl-1-pentanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1270] +xref: UM-BBD_reactionID:r1270 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034864 +name: 2,4,4-trimethylpentanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-." [UM-BBD_reactionID:r1275] +xref: UM-BBD_reactionID:r1275 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0034865 +name: 2,4,4-trimethylpentanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." [UM-BBD_reactionID:r1271] +xref: UM-BBD_reactionID:r1271 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034866 +name: 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1276] +xref: UM-BBD_reactionID:r1276 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034867 +name: 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA." [UM-BBD_reactionID:r1277] +xref: UM-BBD_reactionID:r1277 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034868 +name: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r1273] +xref: UM-BBD_reactionID:r1273 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034869 +name: 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH." [UM-BBD_reactionID:r1307] +xref: UM-BBD_reactionID:r1307 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034870 +name: pinacolone 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one." [UM-BBD_reactionID:r12979] +xref: UM-BBD_reactionID:r12979 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034871 +name: 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-." [UM-BBD_reactionID:r1308] +xref: UM-BBD_reactionID:r1308 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034872 +name: trans-geranyl-CoA isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA." [UM-BBD_reactionID:r1310] +xref: EC:5.2.1.- +xref: UM-BBD_reactionID:r1310 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0034873 +name: thioacetamide S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O." [UM-BBD_reactionID:r1312] +xref: UM-BBD_reactionID:r1312 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034874 +name: thioacetamide S-oxide S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O." [UM-BBD_reactionID:r1313] +xref: UM-BBD_reactionID:r1313 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034875 +name: caffeine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O." [RHEA:47148] +xref: EC:1.17.5.2 +xref: RHEA:47148 +xref: UM-BBD_reactionID:r1321 +is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor + +[Term] +id: GO:0034876 +name: isonicotinic acid hydrazide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine." [UM-BBD_reactionID:r1336] +xref: UM-BBD_reactionID:r1336 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034877 +name: isonicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor." [UM-BBD_reactionID:r1337] +xref: UM-BBD_reactionID:r1337 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034878 +name: 2-hydroxyisonicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor." [UM-BBD_reactionID:r1338] +xref: UM-BBD_reactionID:r1338 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034879 +name: 2,3,6-trihydroxyisonicotinate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2." [UM-BBD_reactionID:r1340] +xref: UM-BBD_reactionID:r1340 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034880 +name: citrazinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1339] +xref: UM-BBD_reactionID:r1339 +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0034881 +name: citrazinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: citrazinate + H2O = cis-aconitamide." [UM-BBD_reactionID:r1343] +xref: UM-BBD_reactionID:r1343 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0034882 +name: cis-aconitamide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3." [UM-BBD_reactionID:r1344] +xref: UM-BBD_reactionID:r1344 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034883 +name: obsolete isonicotinate reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate." [UM-BBD_reactionID:r1347] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "isonicotinate reductase activity" EXACT [] +is_obsolete: true +consider: GO:0016627 + +[Term] +id: GO:0034884 +name: obsolete gamma-N-formylaminovinylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-." [UM-BBD_reactionID:r1349] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "gamma-N-formylaminovinylacetaldehyde dehydrogenase activity" EXACT [] +is_obsolete: true +consider: GO:0016903 + +[Term] +id: GO:0034885 +name: gamma-N-formylaminovinylacetate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH." [UM-BBD_reactionID:r1350] +xref: UM-BBD_reactionID:r1350 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0034886 +name: gamma-aminovinylacetate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3." [UM-BBD_reactionID:r1351] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r1351 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034887 +name: obsolete 1,4-dihydroisonicotinate 2,3-dioxygenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2." [UM-BBD_reactionID:r1348] +comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. +synonym: "1,4-dihydroisonicotinate 2,3-dioxygenase activity" EXACT [] +is_obsolete: true +consider: GO:0016702 + +[Term] +id: GO:0034888 +name: endosulfan monooxygenase I activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O." [UM-BBD_reactionID:r1382] +xref: UM-BBD_reactionID:r1382 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034889 +name: endosulfan hemisulfate sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate." [UM-BBD_reactionID:r1384] +xref: UM-BBD_reactionID:r1384 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0034890 +name: endosulfan diol hydrolyase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O." [UM-BBD_reactionID:r1386] +xref: UM-BBD_reactionID:r1386 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034891 +name: endosulfan diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-." [UM-BBD_reactionID:r1388] +xref: UM-BBD_reactionID:r1388 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034892 +name: endosulfan lactone lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+." [UM-BBD_reactionID:r1389] +xref: UM-BBD_reactionID:r1389 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0034893 +name: N-nitrodimethylamine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O." [UM-BBD_reactionID:r1395] +xref: UM-BBD_reactionID:r1395 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034894 +name: 4-hydroxypyridine-3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+." [UM-BBD_reactionID:r1397] +xref: EC:1.14.13.- +xref: UM-BBD_reactionID:r1397 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034895 +name: pyridine-3,4-diol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate." [UM-BBD_reactionID:r1398] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1398 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034896 +name: 3-formiminopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3." [UM-BBD_reactionID:r1400] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r1400 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034897 +name: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol." [UM-BBD_reactionID:r1358] +xref: UM-BBD_reactionID:r1358 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034898 +name: hexadecyltrimethylammonium chloride monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O." [UM-BBD_reactionID:r1373] +xref: EC:1.13.12.- +xref: UM-BBD_reactionID:r1373 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0034899 +name: trimethylamine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O." [EC:1.14.13.148, UM-BBD_reactionID:r1407] +xref: EC:1.14.13.148 +xref: KEGG_REACTION:R05623 +xref: RHEA:31979 +xref: UM-BBD_reactionID:r1407 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034900 +name: 3-(N-formyl)-formiminopyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate." [UM-BBD_reactionID:r1399] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r1399 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034901 +name: endosulfan hydroxyether dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-." [UM-BBD_reactionID:r1411] +xref: UM-BBD_reactionID:r1411 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034902 +name: endosulfan sulfate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite." [UM-BBD_reactionID:r1387] +xref: UM-BBD_reactionID:r1387 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0034903 +name: endosulfan ether monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O." [UM-BBD_reactionID:r1413] +xref: UM-BBD_reactionID:r1413 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034904 +name: 5-chloro-2-oxopent-4-enoate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate." [UM-BBD_reactionID:r1436] +xref: UM-BBD_reactionID:r1436 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034905 +name: 5-chloro-4-hydroxy-2-oxopentanate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde." [UM-BBD_reactionID:r1437] +xref: EC:4.1.3.- +xref: UM-BBD_reactionID:r1437 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0034906 +name: N-isopropylaniline 1,2-dixoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine." [UM-BBD_reactionID:r0721] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0721 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034907 +name: acetanilide 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide." [UM-BBD_reactionID:r0723] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0723 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034908 +name: 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+." [UM-BBD_reactionID:r0724] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r0724 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034909 +name: 6-hydroxypseudooxynicotine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine." [UM-BBD_reactionID:r1441] +xref: EC:1.5.99.14 +xref: RHEA:34223 +xref: UM-BBD_reactionID:r1441 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0034910 +name: 6-hydroxy-3-succinoylpyridine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine." [UM-BBD_reactionID:r1442] +xref: UM-BBD_reactionID:r1442 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034911 +name: phthalate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+." [UM-BBD_reactionID:r1444] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r1444 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034912 +name: phthalate 3,4-cis-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+." [UM-BBD_reactionID:r1445] +xref: MetaCyc:RXN5F9-56 +xref: UM-BBD_reactionID:r1445 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0034914 +name: trinitrophenol hydride denitratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP." [UM-BBD_reactionID:r1448] +synonym: "2,4,6-trinitrophenol hydride denitratase activity" EXACT [] +synonym: "TNP hydride denitratase activity" EXACT [] +xref: EC:1.7.99.- +xref: UM-BBD_reactionID:r1448 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0034915 +name: 2-methylhexanoyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0927] +xref: EC:2.3.1.- +xref: UM-BBD_reactionID:r0927 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034916 +name: 2-methylhexanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-." [UM-BBD_reactionID:r0928] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r0928 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034917 +name: 2-methylhex-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA." [UM-BBD_reactionID:r0929] +xref: UM-BBD_reactionID:r0929 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034918 +name: 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-." [UM-BBD_reactionID:r0930] +xref: UM-BBD_reactionID:r0930 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034919 +name: butyryl-CoA 2-C-propionyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA." [UM-BBD_reactionID:r0931] +xref: UM-BBD_reactionID:r0931 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034920 +name: pyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0934] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0934 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034921 +name: cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-." [UM-BBD_reactionID:r0935] +xref: UM-BBD_reactionID:r0935 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034922 +name: 4,5-dihydroxypyrene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+." [UM-BBD_reactionID:r0936] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0936 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034923 +name: phenanthrene-4,5-dicarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2." [UM-BBD_reactionID:r0937] +xref: UM-BBD_reactionID:r0937 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034924 +name: cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2." [UM-BBD_reactionID:r0940] +xref: UM-BBD_reactionID:r0940 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0034925 +name: pyrene 4,5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O." [UM-BBD_reactionID:r0941] +xref: UM-BBD_reactionID:r0941 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034926 +name: pyrene-4,5-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene." [UM-BBD_reactionID:r0942] +xref: UM-BBD_reactionID:r0942 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0034927 +name: pyrene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O." [UM-BBD_reactionID:r0943] +xref: UM-BBD_reactionID:r0943 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034928 +name: 1-hydroxypyrene 6,7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0946] +xref: UM-BBD_reactionID:r0946 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034929 +name: 1-hydroxypyrene 7,8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O." [UM-BBD_reactionID:r0949] +xref: UM-BBD_reactionID:r0949 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034930 +name: 1-hydroxypyrene sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX." [UM-BBD_reactionID:r0952] +xref: UM-BBD_reactionID:r0952 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0034931 +name: 1-hydroxypyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX." [UM-BBD_reactionID:r0953] +xref: UM-BBD_reactionID:r0953 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034932 +name: 1-methoxypyrene 6,7-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O." [UM-BBD_reactionID:r0954] +xref: UM-BBD_reactionID:r0954 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034933 +name: 1-hydroxy-6-methoxypyrene methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX." [UM-BBD_reactionID:r0956] +xref: UM-BBD_reactionID:r0956 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0034934 +name: phenanthrene-4-carboxylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate." [UM-BBD_reactionID:r0939] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0939 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034935 +name: tetrachlorobenzene dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+." [UM-BBD_reactionID:r0957] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0957 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034936 +name: 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+." [UM-BBD_reactionID:r0959] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r0959 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034937 +name: perchlorate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O." [UM-BBD_reactionID:r0980] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r0980 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034938 +name: pyrrole-2-carboxylate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O." [UM-BBD_reactionID:r0968] +xref: EC:1.14.14.- +xref: UM-BBD_reactionID:r0968 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0034939 +name: 5-hydroxypyrrole-2-carboxylate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate." [UM-BBD_reactionID:r0969] +xref: UM-BBD_reactionID:r0969 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0034940 +name: 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3." [UM-BBD_reactionID:r0984] +xref: UM-BBD_reactionID:r0984 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0034941 +name: pyrrole-2-carboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2." [UM-BBD_reactionID:r0970] +xref: EC:4.1.1.93 +xref: UM-BBD_reactionID:r0970 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034942 +name: cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0988] +xref: UM-BBD_reactionID:r0988 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034943 +name: trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi." [UM-BBD_reactionID:r0989] +xref: UM-BBD_reactionID:r0989 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0034944 +name: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+." [UM-BBD_reactionID:r0986] +xref: UM-BBD_reactionID:r0986 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0034945 +name: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA." [UM-BBD_reactionID:r0987] +xref: EC:2.3.1.- +xref: UM-BBD_reactionID:r0987 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0034946 +name: 3-isopropylbut-3-enoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH." [UM-BBD_reactionID:r0994] +xref: UM-BBD_reactionID:r0994 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0034947 +name: terephthalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-." [UM-BBD_reactionID:r0321] +xref: UM-BBD_reactionID:r0321 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034948 +name: 2,6-dihydroxypseudooxynicotine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate." [UM-BBD_reactionID:r0482] +xref: EC:3.7.1.- +xref: UM-BBD_reactionID:r0482 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0034949 +name: 1,1-dichloroethane reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl." [UM-BBD_reactionID:r1008] +xref: EC:1.97.1.- +xref: UM-BBD_reactionID:r1008 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0034950 +name: phenylboronic acid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3." [UM-BBD_reactionID:r1020] +xref: UM-BBD_reactionID:r1020 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0034951 +name: o-hydroxylaminobenzoate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate." [UM-BBD_reactionID:r1026] +xref: EC:5.4.99.- +xref: MetaCyc:RXN-8846 +xref: UM-BBD_reactionID:r1026 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0034952 +name: malonate semialdehyde decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2." [UM-BBD_reactionID:r0266] +xref: UM-BBD_reactionID:r0266 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0034953 +name: perillyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r1002] +xref: UM-BBD_reactionID:r1002 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0034954 +name: diphenyl ether 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether." [UM-BBD_reactionID:r1450] +xref: EC:1.14.12.- +xref: UM-BBD_reactionID:r1450 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0034955 +name: 2,3-dihydroxydiphenyl ether dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol." [UM-BBD_reactionID:r1451] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1451 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034956 +name: diphenyl ether 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+." [UM-BBD_reactionID:r1453] +xref: EC:1.13.11.- +xref: UM-BBD_reactionID:r1453 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0034957 +name: 3-nitrophenol nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O." [UM-BBD_reactionID:r1495] +xref: UM-BBD_reactionID:r1495 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0034958 +name: aminohydroquinone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3." [UM-BBD_reactionID:r1497] +xref: EC:3.5.99.- +xref: UM-BBD_reactionID:r1497 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0034959 +name: endothelin maturation +namespace: biological_process +def: "The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin." [GOC:BHF, GOC:rl] +is_a: GO:0016486 ! peptide hormone processing +relationship: part_of GO:0003100 ! regulation of systemic arterial blood pressure by endothelin + +[Term] +id: GO:0034963 +name: box C/D RNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA." [GOC:krc, GOC:mah] +synonym: "box C/D snoRNA processing" NARROW [] +synonym: "box C/D sRNA processing" NARROW [] +is_a: GO:0033967 ! box C/D RNA metabolic process +is_a: GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:0034964 +name: box H/ACA RNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA." [GOC:krc, GOC:mah] +synonym: "box H/ACA snoRNA processing" NARROW [] +synonym: "box H/ACA sRNA processing" NARROW [] +is_a: GO:0033979 ! box H/ACA RNA metabolic process +is_a: GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:0034965 +name: intronic box C/D RNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA." [GOC:krc, GOC:mah] +synonym: "intronic box C/D snoRNA processing" NARROW [] +synonym: "intronic box C/D sRNA processing" NARROW [] +is_a: GO:0031070 ! intronic snoRNA processing +is_a: GO:0034963 ! box C/D RNA processing + +[Term] +id: GO:0034966 +name: intronic box H/ACA snoRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA." [GOC:mah] +is_a: GO:0031070 ! intronic snoRNA processing +is_a: GO:0034964 ! box H/ACA RNA processing + +[Term] +id: GO:0034967 +name: Set3 complex +namespace: cellular_component +def: "A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p." [GOC:ds, PMID:11711434] +synonym: "HDAC3 complex" EXACT [] +synonym: "SET3C" EXACT [] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0034968 +name: histone lysine methylation +namespace: biological_process +def: "The modification of a histone by addition of one or more methyl groups to a lysine residue." [GOC:mah, GOC:pr] +is_a: GO:0016571 ! histone methylation +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0034969 +name: histone arginine methylation +namespace: biological_process +def: "The modification of a histone by addition of a methyl group to an arginine residue." [GOC:mah] +is_a: GO:0016571 ! histone methylation +is_a: GO:0018216 ! peptidyl-arginine methylation + +[Term] +id: GO:0034970 +name: histone H3-R2 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone." [GOC:mah] +synonym: "histone H3 R2 methylation" EXACT [] +synonym: "histone H3R2me" EXACT [] +synonym: "histone lysine H3 R2 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034971 +name: histone H3-R17 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone." [GOC:mah] +synonym: "histone H3 R17 methylation" EXACT [] +synonym: "histone H3R17me" EXACT [] +synonym: "histone lysine H3 R17 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034972 +name: histone H3-R26 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone." [GOC:mah] +synonym: "histone H3 R26 methylation" EXACT [] +synonym: "histone H3R26me" EXACT [] +synonym: "histone lysine H3 R26 methylation" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0034973 +name: Sid2-Mob1 complex +namespace: cellular_component +def: "A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex." [GOC:vw, PMID:10837231, PMID:15060149] +synonym: "Dbf2p-Mob1p complex" EXACT [] +synonym: "Sid2-Mob1 kinase complex" EXACT [] +synonym: "Sid2p-Mob1p complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034974 +name: Swi5-Swi2 complex +namespace: cellular_component +def: "A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching." [PMID:14663140] +comment: Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p. +synonym: "Swi5 complex" BROAD [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0034975 +name: protein folding in endoplasmic reticulum +namespace: biological_process +def: "A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:mah, GOC:vw] +synonym: "oxidative protein folding" EXACT [PMID:25091901] +synonym: "protein folding in ER" EXACT [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0034976 +name: response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] +synonym: "cellular response to endoplasmic reticulum stress" EXACT [] +synonym: "ER stress response" EXACT [] +synonym: "response to ER stress" EXACT [] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0034977 +name: ABIN2-NFKB1-MAP3K8 complex +namespace: cellular_component +def: "A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." [PMID:15169888] +synonym: "ABIN2-NFKB1-TPL-1 complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0034978 +name: PDX1-PBX1b-MRG1 complex +namespace: cellular_component +def: "A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes." [PMID:11279116, PMID:9710595] +synonym: "acinar cell-specific C complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034979 +name: NAD-dependent protein deacetylase activity +namespace: molecular_function +def: "Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD." [GOC:BHF, GOC:mah, PMID:28450737] +xref: Reactome:R-HSA-3371467 "SIRT1 deacetylates HSF1" +xref: Reactome:R-HSA-5211239 "SIRT1 deacetylates TAF1B in SL1 complex" +xref: Reactome:R-HSA-5685953 "SIRT6 deacetylates RBBP8" +xref: Reactome:R-HSA-5688289 "SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2" +xref: Reactome:R-HSA-5688294 "SIRT5 deacetylates Cytochrome C" +xref: Reactome:R-HSA-9620532 "SIRT1,SIRT3 deacetylate FOXO3" +xref: Reactome:R-HSA-9667952 "ANKLE2 is deacetylated by SIRT2" +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0034980 +name: FHL2-CREB complex +namespace: cellular_component +def: "A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation." [PMID:11046156] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034981 +name: FHL3-CREB complex +namespace: cellular_component +def: "A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation." [PMID:11046156] +is_a: GO:0033202 ! DNA helicase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0034982 +name: mitochondrial protein processing +namespace: biological_process +def: "The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." [GOC:curators] +synonym: "mitochondrial protein modification" RELATED [] +is_a: GO:0016485 ! protein processing +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0034983 +name: peptidyl-lysine deacetylation +namespace: biological_process +def: "The removal of an acetyl group from an acetylated lysine residue in a peptide or protein." [GOC:BHF, GOC:mah] +synonym: "protein lysine acetylation" RELATED [] +is_a: GO:0006476 ! protein deacetylation +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0034985 +name: Ecsit-NDUFAF1 complex +namespace: cellular_component +def: "Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed." [PMID:17344420] +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0034986 +name: iron chaperone activity +namespace: molecular_function +def: "Directly binding to and delivering iron ions to a target protein." [GOC:BHF, GOC:vk] +is_a: GO:0016530 ! metallochaperone activity + +[Term] +id: GO:0034987 +name: immunoglobulin receptor binding +namespace: molecular_function +def: "Binding to one or more specific sites on an immunoglobulin receptor molecule." [GOC:BHF, GOC:vk] +synonym: "Fc receptor binding" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0034988 +name: Fc-gamma receptor I complex binding +namespace: molecular_function +def: "Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG." [GOC:BHF, GOC:vk] +is_a: GO:0034987 ! immunoglobulin receptor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0034990 +name: nuclear mitotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah] +comment: Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. +is_a: GO:0000798 ! nuclear cohesin complex +is_a: GO:0030892 ! mitotic cohesin complex + +[Term] +id: GO:0034991 +name: nuclear meiotic cohesin complex +namespace: cellular_component +def: "A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah] +is_a: GO:0000798 ! nuclear cohesin complex +is_a: GO:0030893 ! meiotic cohesin complex + +[Term] +id: GO:0034992 +name: microtubule organizing center attachment site +namespace: cellular_component +def: "A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope." [GOC:mah, PMID:18692466] +comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. +synonym: "MAS" EXACT [] +synonym: "microtubule organising centre attachment site" EXACT [] +synonym: "MTOC attachment site" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0034993 +name: meiotic nuclear membrane microtubule tethering complex +namespace: cellular_component +def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis." [GOC:mah, PMID:18692466] +synonym: "LINC complex" EXACT [] +synonym: "LInker of Nucleoskeleton and Cytoskeleton complex" EXACT [] +synonym: "SUN-KASH complex" EXACT [] +is_a: GO:0106094 ! nuclear membrane microtubule tethering complex +relationship: part_of GO:0034992 ! microtubule organizing center attachment site + +[Term] +id: GO:0034994 +name: microtubule organizing center attachment site organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches." [GOC:mah, PMID:18692466] +synonym: "MAS organization" EXACT [] +synonym: "microtubule organising centre attachment site organisation" RELATED [] +synonym: "MTOC attachment site organization" EXACT [] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0006998 ! nuclear envelope organization + +[Term] +id: GO:0034995 +name: SC5b-7 complex +namespace: cellular_component +def: "A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly." [PMID:10090939] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0034996 +name: RasGAP-Fyn-Lyn-Yes complex +namespace: cellular_component +def: "A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." [PMID:1544885] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +synonym: "p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0034997 +name: alphav-beta5 integrin-vitronectin complex +namespace: cellular_component +def: "A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin." [PMID:1694173] +synonym: "ITGAV-ITGB5-VTN complex" NARROW [CORUM:3117] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0034998 +name: oligosaccharyltransferase I complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes." [PMID:15835887] +synonym: "OSTCI" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0034999 +name: oligosaccharyltransferase II complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes." [GOC:BHF, PMID:15835887] +synonym: "OSTCII" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0035000 +name: oligosaccharyltransferase III complex +namespace: cellular_component +def: "An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes." [PMID:15835887] +synonym: "OSTCIII" EXACT [] +is_a: GO:0008250 ! oligosaccharyltransferase complex + +[Term] +id: GO:0035001 +name: dorsal trunk growth, open tracheal system +namespace: biological_process +def: "Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "dorsal trunk growth" RELATED [] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035002 +name: liquid clearance, open tracheal system +namespace: biological_process +def: "The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system." [GOC:mtg_sensu, PMID:12571352] +synonym: "tracheal liquid clearance" EXACT [] +is_a: GO:0042045 ! epithelial fluid transport +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035003 +name: subapical complex +namespace: cellular_component +def: "The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells." [PMID:11752566, PMID:12500938] +synonym: "SAC" BROAD [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0043296 ! apical junction complex + +[Term] +id: GO:0035004 +name: phosphatidylinositol 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring." [GOC:bf, PMID:10209156, PMID:9255069] +synonym: "phosphoinositide 3-kinase activity" EXACT [] +xref: Reactome:R-HSA-1433514 "Synthesis of PIP3 from PIP2 by PI3K" +xref: Reactome:R-HSA-2045911 "BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3" +xref: Reactome:R-HSA-9028519 "NTRK2-activated PI3K generates PIP3" +xref: Reactome:R-HSA-9670433 "KIT mutants:PI3K catalyze synthesis of PIP3" +xref: Wikipedia:Phosphoinositide_3-kinase +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0035005 +name: 1-phosphatidylinositol-4-phosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.154, RHEA:18373] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity" RELATED [EC:2.7.1.154] +synonym: "C2-domain-containing phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.154] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "phosphatidylinositol-4-phosphate 3-kinase activity" EXACT [] +synonym: "type II phosphoinositide 3-kinase activity" RELATED [EC:2.7.1.154] +xref: EC:2.7.1.154 +xref: KEGG_REACTION:R05795 +xref: MetaCyc:2.7.1.154-RXN +xref: Reactome:R-HSA-1675928 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A/G at the Golgi membrane" +xref: Reactome:R-HSA-1676109 "PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane" +xref: Reactome:R-HSA-1676206 "PI4P is phosphorylated to PI(3,4)P2 by PIK3C2A at the early endosome membrane" +xref: Reactome:R-HSA-8868072 "Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2" +xref: RHEA:18373 +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity +is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity + +[Term] +id: GO:0035006 +name: melanization defense response +namespace: biological_process +def: "The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin." [GOC:bf, PMID:12408809] +synonym: "melanization defence response" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0035007 +name: regulation of melanization defense response +namespace: biological_process +def: "Any process that affects the rate, extent or location of the melanization defense response during injury or invasion." [GOC:bf] +synonym: "regulation of melanization defence response" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035008 +name: positive regulation of melanization defense response +namespace: biological_process +def: "Any process that increases the rate or extent of the melanization defense response during injury or invasion." [GOC:bf] +synonym: "activation of melanization defense response" NARROW [] +synonym: "positive regulation of melanization defence response" EXACT [] +synonym: "stimulation of melanization defense response" NARROW [] +synonym: "up regulation of melanization defense response" EXACT [] +synonym: "up-regulation of melanization defense response" EXACT [] +synonym: "upregulation of melanization defense response" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0035007 ! regulation of melanization defense response +is_a: GO:0045089 ! positive regulation of innate immune response +relationship: positively_regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035009 +name: negative regulation of melanization defense response +namespace: biological_process +def: "Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection." [GOC:bf, PMID:12408809] +synonym: "down regulation of melanization defense response" EXACT [] +synonym: "down-regulation of melanization defense response" EXACT [] +synonym: "downregulation of melanization defense response" EXACT [] +synonym: "inhibition of melanization defense response" NARROW [] +synonym: "negative regulation of melanization defence response" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0035007 ! regulation of melanization defense response +is_a: GO:0045824 ! negative regulation of innate immune response +relationship: negatively_regulates GO:0035006 ! melanization defense response + +[Term] +id: GO:0035010 +name: encapsulation of foreign target +namespace: biological_process +def: "Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." [GO_REF:0000022, GOC:bf, PMID:11846478, PMID:12225920] +is_a: GO:0002252 ! immune effector process + +[Term] +id: GO:0035011 +name: melanotic encapsulation of foreign target +namespace: biological_process +def: "Formation of a multilayered, melanized sheath of cells around a foreign invader." [GOC:bf] +is_a: GO:0035006 ! melanization defense response +is_a: GO:0035010 ! encapsulation of foreign target + +[Term] +id: GO:0035012 +name: obsolete polytene chromosome, telomeric region +namespace: cellular_component +def: "OBSOLETE. The terminal region of a polytene chromosome." [GOC:bf] +comment: This term was obsoleted because it likely represents an assay for GO:0099115 chromosome, subtelomeric region. +is_obsolete: true + +[Term] +id: GO:0035013 +name: myosuppressin receptor activity +namespace: molecular_function +def: "Combining with the peptide myosuppressin to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0035014 +name: phosphatidylinositol 3-kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates." [GOC:bf, PMID:9255069] +comment: See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. +synonym: "phosphoinositide 3-kinase regulator activity" EXACT [] +synonym: "PI3K regulator activity" EXACT [] +is_a: GO:0019207 ! kinase regulator activity + +[Term] +id: GO:0035015 +name: elongation of arista core +namespace: biological_process +def: "The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0035016 +name: elongation of arista lateral +namespace: biological_process +def: "The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions." [GOC:bf, PMID:11404081] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0035017 +name: cuticle pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the patterns of cell differentiation in the cuticle." [GOC:bf] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0035018 +name: adult chitin-based cuticle pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "adult cuticle pattern formation" BROAD [] +is_a: GO:0035017 ! cuticle pattern formation +relationship: part_of GO:0008365 ! adult chitin-based cuticle development + +[Term] +id: GO:0035019 +name: somatic stem cell population maintenance +namespace: biological_process +def: "Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line." [GOC:bf, ISBN:0582227089] +is_a: GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:0035020 +name: regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035021 +name: negative regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +synonym: "down regulation of Rac protein signal transduction" EXACT [] +synonym: "down-regulation of Rac protein signal transduction" EXACT [] +synonym: "downregulation of Rac protein signal transduction" EXACT [] +synonym: "inhibition of Rac protein signal transduction" NARROW [] +is_a: GO:0035020 ! regulation of Rac protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035022 +name: positive regulation of Rac protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction." [GOC:bf] +synonym: "activation of Rac protein signal transduction" NARROW [] +synonym: "stimulation of Rac protein signal transduction" NARROW [] +synonym: "up regulation of Rac protein signal transduction" EXACT [] +synonym: "up-regulation of Rac protein signal transduction" EXACT [] +synonym: "upregulation of Rac protein signal transduction" EXACT [] +is_a: GO:0035020 ! regulation of Rac protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0016601 ! Rac protein signal transduction + +[Term] +id: GO:0035023 +name: regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +relationship: regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035024 +name: negative regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +synonym: "down regulation of Rho protein signal transduction" EXACT [] +synonym: "down-regulation of Rho protein signal transduction" EXACT [] +synonym: "downregulation of Rho protein signal transduction" EXACT [] +synonym: "inhibition of Rho protein signal transduction" NARROW [] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +is_a: GO:0046580 ! negative regulation of Ras protein signal transduction +relationship: negatively_regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035025 +name: positive regulation of Rho protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction." [GOC:bf] +synonym: "activation of Rho protein signal transduction" NARROW [] +synonym: "stimulation of Rho protein signal transduction" NARROW [] +synonym: "up regulation of Rho protein signal transduction" EXACT [] +synonym: "up-regulation of Rho protein signal transduction" EXACT [] +synonym: "upregulation of Rho protein signal transduction" EXACT [] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +is_a: GO:0046579 ! positive regulation of Ras protein signal transduction +relationship: positively_regulates GO:0007266 ! Rho protein signal transduction + +[Term] +id: GO:0035026 +name: leading edge cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet." [GOC:bf] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0035027 +name: leading edge cell fate commitment +namespace: biological_process +def: "The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet." [GOC:bf] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0035026 ! leading edge cell differentiation + +[Term] +id: GO:0035028 +name: leading edge cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0035027 ! leading edge cell fate commitment + +[Term] +id: GO:0035029 +name: dorsal closure, leading edge cell fate commitment +namespace: biological_process +def: "The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis." [GOC:bf] +is_a: GO:0035027 ! leading edge cell fate commitment +relationship: part_of GO:0046663 ! dorsal closure, leading edge cell differentiation + +[Term] +id: GO:0035032 +name: phosphatidylinositol 3-kinase complex, class III +namespace: cellular_component +def: "A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI)." [GOC:bf, PMID:9255069] +synonym: "class III PI3K complex" EXACT [] +synonym: "phosphoinositide 3-kinase complex, class III" EXACT [] +is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex + +[Term] +id: GO:0035033 +name: histone deacetylase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of histone deacetylase." [GOC:bf] +comment: See also the molecular function term 'histone deacetylase activity ; GO:0004407'. +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0035034 +name: histone acetyltransferase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of histone acetyltransferase." [GOC:bf] +comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. +synonym: "histone acetylase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0035035 +name: histone acetyltransferase binding +namespace: molecular_function +def: "Binding to an histone acetyltransferase." [GOC:bf] +synonym: "histone acetylase binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035036 +name: sperm-egg recognition +namespace: biological_process +def: "The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization." [GOC:bf] +is_a: GO:0009988 ! cell-cell recognition +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035037 +name: sperm entry +namespace: biological_process +def: "An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur." [GOC:bf, PMID:9630751] +is_a: GO:0006897 ! endocytosis +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035038 +name: female pronucleus assembly +namespace: biological_process +def: "Assembly of the haploid nucleus of the unfertilized egg." [GOC:bf, ISBN:0582227089] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0022414 ! reproductive process +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035039 +name: male pronucleus assembly +namespace: biological_process +def: "The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division." [GOC:bf, PMID:11735001] +synonym: "male pronucleus formation" RELATED [GOC:dph] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0022414 ! reproductive process +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035040 +name: sperm nuclear envelope removal +namespace: biological_process +def: "Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus." [GOC:bf, PMID:11735001] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051081 ! nuclear membrane disassembly +relationship: part_of GO:0035039 ! male pronucleus assembly + +[Term] +id: GO:0035041 +name: sperm DNA decondensation +namespace: biological_process +def: "Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus." [GOC:bf, PMID:11735001] +synonym: "sperm chromatin decondensation" EXACT [] +is_a: GO:0006325 ! chromatin organization +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0035039 ! male pronucleus assembly + +[Term] +id: GO:0035042 +name: fertilization, exchange of chromosomal proteins +namespace: biological_process +def: "Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity." [GOC:bf, PMID:11735001] +synonym: "sperm-specific histone exchange" EXACT [] +synonym: "sperm-specific histone replacement" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0043486 ! histone exchange +relationship: part_of GO:0035041 ! sperm DNA decondensation + +[Term] +id: GO:0035043 +name: male pronuclear envelope synthesis +namespace: biological_process +def: "Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation." [GOC:bf, PMID:11735001] +is_a: GO:0018985 ! pronuclear envelope synthesis +relationship: part_of GO:0035039 ! male pronucleus assembly + +[Term] +id: GO:0035044 +name: sperm aster formation +namespace: biological_process +def: "Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei." [GOC:bf, ISBN:0879694238] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035045 +name: sperm plasma membrane disassembly +namespace: biological_process +def: "The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg." [GOC:bf, ISBN:0879694238] +synonym: "sperm plasma membrane breakdown" EXACT [] +synonym: "sperm plasma membrane catabolism" EXACT [] +synonym: "sperm plasma membrane degradation" EXACT [] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030397 ! membrane disassembly +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035046 +name: pronuclear migration +namespace: biological_process +def: "The directed movement of the male and female pronuclei towards each other prior to their fusion." [GOC:bf, PMID:9199363] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035047 +name: centrosomal and pronuclear rotation +namespace: biological_process +def: "The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion." [GOC:bf, ISBN:087969307X, PMID:10085292] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0035048 +name: obsolete splicing factor protein import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:bf] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "splicing factor protein transport from cytoplasm to nucleus" EXACT [] +synonym: "splicing factor protein-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0035049 +name: juvenile hormone acid methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to juvenile hormone acid." [GOC:bf] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0035050 +name: embryonic heart tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field." [GOC:go_curators] +is_a: GO:0035295 ! tube development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0007507 ! heart development +relationship: part_of GO:0048568 ! embryonic organ development + +[Term] +id: GO:0035051 +name: cardiocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual." [GOC:bf] +synonym: "cardiac cell differentiation" EXACT [] +synonym: "heart cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0035052 +name: dorsal vessel aortic cell fate commitment +namespace: biological_process +def: "The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] +is_a: GO:0060581 ! cell fate commitment involved in pattern specification +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification + +[Term] +id: GO:0035053 +name: dorsal vessel heart proper cell fate commitment +namespace: biological_process +def: "The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12397110] +is_a: GO:0060581 ! cell fate commitment involved in pattern specification +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0035054 ! embryonic heart tube anterior/posterior pattern specification + +[Term] +id: GO:0035054 +name: embryonic heart tube anterior/posterior pattern specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta." [GOC:bf, PMID:12435360] +is_a: GO:0009952 ! anterior/posterior pattern specification +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0035059 +name: RCAF complex +namespace: cellular_component +def: "A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4." [GOC:bf, PMID:10591219] +synonym: "replication-coupling assembly factor complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0035060 +name: brahma complex +namespace: cellular_component +def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof." [GOC:bhm, PMID:10809665, PMID:12482982] +synonym: "BRM complex" EXACT [] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0035061 +name: interchromatin granule +namespace: cellular_component +def: "A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] +synonym: "ICG" EXACT [] +xref: NIF_Subcellular:sao1049471211 +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0035062 +name: omega speckle +namespace: cellular_component +def: "A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs)." [GOC:bf, PMID:10984439] +is_a: GO:0016607 ! nuclear speck + +[Term] +id: GO:0035063 +name: nuclear speck organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized." [GOC:bf, GOC:curators] +comment: See also the cellular component term 'nuclear speck ; GO:0016607'. +synonym: "nuclear speck organisation" EXACT [] +synonym: "nuclear speck organization and biogenesis" RELATED [GOC:mah] +synonym: "nuclear speckle assembly" NARROW [GOC:mah] +synonym: "nuclear speckle organization" EXACT [] +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:0035064 +name: methylated histone binding +namespace: molecular_function +def: "Binding to a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf, PMID:14585615] +is_a: GO:0042393 ! histone binding +is_a: GO:0140034 ! methylation-dependent protein binding + +[Term] +id: GO:0035065 +name: regulation of histone acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation +relationship: regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035066 +name: positive regulation of histone acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +synonym: "activation of histone acetylation" NARROW [] +synonym: "stimulation of histone acetylation" NARROW [] +synonym: "up regulation of histone acetylation" EXACT [] +synonym: "up-regulation of histone acetylation" EXACT [] +synonym: "upregulation of histone acetylation" EXACT [] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0035065 ! regulation of histone acetylation +is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation +relationship: positively_regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035067 +name: negative regulation of histone acetylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein." [GOC:bf] +synonym: "down regulation of histone acetylation" EXACT [] +synonym: "down-regulation of histone acetylation" EXACT [] +synonym: "downregulation of histone acetylation" EXACT [] +synonym: "inhibition of histone acetylation" NARROW [] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0035065 ! regulation of histone acetylation +is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation +relationship: negatively_regulates GO:0016573 ! histone acetylation + +[Term] +id: GO:0035069 +name: larval midgut histolysis +namespace: biological_process +def: "The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683] +synonym: "larval midgut regression" EXACT [] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0035070 +name: salivary gland histolysis +namespace: biological_process +def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683] +synonym: "salivary gland regression" EXACT [] +is_a: GO:0007435 ! salivary gland morphogenesis +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0007552 ! metamorphosis +relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis + +[Term] +id: GO:0035071 +name: salivary gland cell autophagic cell death +namespace: biological_process +def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] +synonym: "autophagic cell death of salivary gland cells" EXACT [] +synonym: "programmed cell death of salivary gland cells by autophagy" EXACT [] +synonym: "salivary gland cell death" EXACT [] +synonym: "salivary gland cell programmed cell death by autophagy" EXACT [] +is_a: GO:0010623 ! programmed cell death involved in cell development +is_a: GO:0048102 ! autophagic cell death +relationship: part_of GO:0035070 ! salivary gland histolysis + +[Term] +id: GO:0035072 +name: ecdysone-mediated induction of salivary gland cell autophagic cell death +namespace: biological_process +def: "Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis." [GOC:bf] +synonym: "ecdysone-mediated induction of autophagic cell death of salivary gland cells" EXACT [] +synonym: "ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy" EXACT [] +synonym: "ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy" EXACT [] +is_a: GO:0035078 ! induction of programmed cell death by ecdysone +relationship: part_of GO:0035071 ! salivary gland cell autophagic cell death + +[Term] +id: GO:0035073 +name: pupariation +namespace: biological_process +def: "The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis." [GOC:bf, ISBN:0879694238, PMID:9409683] +synonym: "puparium biosynthesis" EXACT [] +synonym: "puparium formation" EXACT [] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0035210 ! prepupal development + +[Term] +id: GO:0035074 +name: pupation +namespace: biological_process +def: "The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period." [GOC:bf, ISBN:0582227089, ISBN:0879694238] +synonym: "head eversion" EXACT [] +synonym: "prepupal-pupal transition" EXACT [] +xref: Wikipedia:Pupa +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0035209 ! pupal development + +[Term] +id: GO:0035075 +name: response to ecdysone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:bf] +is_a: GO:0036314 ! response to sterol +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0035076 +name: ecdysone receptor-mediated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex." [GOC:bf] +synonym: "ecdysone receptor-mediated signalling pathway" EXACT [] +is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway +relationship: part_of GO:0071390 ! cellular response to ecdysone + +[Term] +id: GO:0035077 +name: ecdysone-mediated polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation." [GOC:bf, PMID:12543962] +is_a: GO:0035079 ! polytene chromosome puffing +relationship: part_of GO:0071390 ! cellular response to ecdysone + +[Term] +id: GO:0035078 +name: induction of programmed cell death by ecdysone +namespace: biological_process +def: "Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death." [GOC:bf] +is_a: GO:0035081 ! induction of programmed cell death by hormones +relationship: part_of GO:0035075 ! response to ecdysone + +[Term] +id: GO:0035079 +name: polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals." [GOC:bf, PMID:12543962] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0035080 +name: heat shock-mediated polytene chromosome puffing +namespace: biological_process +def: "The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus." [GOC:bf, PMID:12543962] +is_a: GO:0034605 ! cellular response to heat +is_a: GO:0035079 ! polytene chromosome puffing + +[Term] +id: GO:0035081 +name: induction of programmed cell death by hormones +namespace: biological_process +def: "Any process induced by hormones that directly activates any of the steps required for programmed cell death." [GOC:bf] +is_a: GO:0012502 ! induction of programmed cell death + +[Term] +id: GO:0035082 +name: axoneme assembly +namespace: biological_process +alt_id: GO:0035083 +alt_id: GO:0035084 +def: "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, GOC:jl, ISBN:0815316194] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "axoneme biogenesis" RELATED [GOC:mah] +synonym: "ciliary axoneme assembly" EXACT [] +synonym: "cilium axoneme assembly" EXACT [] +synonym: "cilium axoneme biogenesis" RELATED [GOC:mah] +synonym: "flagellar axoneme assembly" EXACT [] +synonym: "flagellum axoneme assembly" EXACT [] +is_a: GO:0001578 ! microtubule bundle formation +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:0035087 +name: siRNA loading onto RISC involved in RNA interference +namespace: biological_process +def: "The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference." [GOC:bf, GOC:mah, PMID:14512631] +synonym: "RNA interference, siRNA loading onto RISC" EXACT [GOC:mah] +is_a: GO:0070922 ! small RNA loading onto RISC +relationship: part_of GO:0016246 ! RNA interference + +[Term] +id: GO:0035088 +name: establishment or maintenance of apical/basal cell polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components." [GOC:bf, GOC:mah, PMID:10934483] +is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity + +[Term] +id: GO:0035089 +name: establishment of apical/basal cell polarity +namespace: biological_process +def: "The specification and formation of the polarity of a cell along its apical/basal axis." [GOC:bf] +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity +is_a: GO:0061162 ! establishment of monopolar cell polarity + +[Term] +id: GO:0035090 +name: maintenance of apical/basal cell polarity +namespace: biological_process +def: "Retaining the established polarization of a cell along its apical/basal axis." [GOC:bf] +is_a: GO:0030011 ! maintenance of cell polarity +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity + +[Term] +id: GO:0035091 +name: phosphatidylinositol binding +namespace: molecular_function +def: "Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, ISBN:0198506732, PMID:11395417] +synonym: "phosphoinositide binding" EXACT [] +is_a: GO:0005543 ! phospholipid binding + +[Term] +id: GO:0035092 +name: sperm DNA condensation +namespace: biological_process +def: "The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication." [GOC:bf, PMID:11735001] +synonym: "sperm chromatin condensation" EXACT [] +is_a: GO:0006323 ! DNA packaging +is_a: GO:0006325 ! chromatin organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0035093 +name: spermatogenesis, exchange of chromosomal proteins +namespace: biological_process +def: "The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin." [GOC:bf, PMID:11735001] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0043486 ! histone exchange +relationship: part_of GO:0035092 ! sperm DNA condensation + +[Term] +id: GO:0035094 +name: response to nicotine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:bf, GOC:ef, ISBN:0198506732, ISBN:0582227089] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0035095 +name: behavioral response to nicotine +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus." [GOC:bf, ISBN:0198506732] +synonym: "behavioural response to nicotine" EXACT [] +is_a: GO:0030534 ! adult behavior +relationship: part_of GO:0035094 ! response to nicotine + +[Term] +id: GO:0035096 +name: larval midgut cell programmed cell death +namespace: biological_process +def: "The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ." [GOC:bf, GOC:mtg_apoptosis] +synonym: "larval midgut cell death" EXACT [] +synonym: "programmed cell death of larval midgut cells" EXACT [] +is_a: GO:0010623 ! programmed cell death involved in cell development +relationship: part_of GO:0035069 ! larval midgut histolysis + +[Term] +id: GO:0035097 +name: histone methyltransferase complex +namespace: cellular_component +def: "A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." [GOC:bf] +subset: goslim_pir +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:0035098 +name: ESC/E(Z) complex +namespace: cellular_component +def: "A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4." [GOC:bf, GOC:sp, PMID:12408863, PMID:12408864, PMID:20064375] +synonym: "Extra Sex Combs/Enhancer of Zeste complex" EXACT [] +synonym: "PRC2 complex" EXACT [GOC:sp, PMID:20064375] +is_a: GO:0031519 ! PcG protein complex +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0035099 +name: hemocyte migration +namespace: biological_process +def: "The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo." [GOC:bf, GOC:mtg_sensu, PMID:12885551] +synonym: "arthropod blood cell migration" EXACT [] +synonym: "hemocyte cell migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0035100 +name: ecdysone binding +namespace: molecular_function +def: "Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting." [GOC:bf, ISBN:0198506732, ISBN:0582227089] +is_a: GO:0032934 ! sterol binding +is_a: GO:0042562 ! hormone binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0035101 +name: FACT complex +namespace: cellular_component +def: "A histone chaperone complex that facilitates nucleosome disassembly and reassembly upon DNA or RNA polymerase passage." [PMID:12934006, PMID:12934007, PMID:16678108, PMID:34731638] +synonym: "Facilitates chromatin transcription complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0035102 +name: PRC1 complex +namespace: cellular_component +def: "A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling." [GOC:bf, PMID:10412979] +comment: In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner. +synonym: "Polycomb repressive complex 1" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0031519 ! PcG protein complex + +[Term] +id: GO:0035103 +name: sterol regulatory element binding protein cleavage +namespace: biological_process +alt_id: GO:0006992 +def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids." [GOC:bf, GOC:vw, PMID:12923525] +synonym: "SREBP cleavage" EXACT [] +synonym: "sterol depletion response, SREBP cleavage" EXACT [] +synonym: "sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway" NARROW [GOC:vw] +is_a: GO:0016485 ! protein processing +is_a: GO:0044267 ! cellular protein metabolic process +relationship: part_of GO:0032933 ! SREBP signaling pathway + +[Term] +id: GO:0035105 +name: obsolete sterol regulatory element binding protein import into nucleus +namespace: biological_process +alt_id: GO:0006993 +def: "OBSOLETE. The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, GOC:vw, PMID:12923525] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "SREBP import into nucleus" EXACT [GOC:mah] +synonym: "SREBP import into nucleus involved in sterol depletion response" EXACT [GOC:mah] +synonym: "SREBP nuclear translocation" NARROW [GOC:mah] +synonym: "sterol depletion response, SREBP import into nucleus" EXACT [GOC:mah] +synonym: "sterol depletion response, SREBP nuclear translocation" NARROW [GOC:mah] +synonym: "sterol depletion response, sterol regulatory element binding protein import into nucleus" EXACT [] +synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" NARROW [GOC:dph, GOC:mah, GOC:tb] +synonym: "sterol regulatory element binding protein import into nucleus involved in sterol depletion response" NARROW [GOC:vw] +synonym: "sterol regulatory element binding protein nuclear translocation" NARROW [GOC:mah] +synonym: "sterol regulatory element binding protein nuclear translocation involved in sterol depletion response" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0006606 +consider: GO:0042306 + +[Term] +id: GO:0035106 +name: operant conditioning +namespace: biological_process +def: "Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." [PMID:14662373] +synonym: "instrumental conditioning" EXACT [] +xref: Wikipedia:Operant_conditioning +is_a: GO:0007612 ! learning + +[Term] +id: GO:0035107 +name: appendage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048736 ! appendage development + +[Term] +id: GO:0035108 +name: limb morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping." [UBERON:0002101] +synonym: "limb bud morphogenesis" NARROW [GOC:dph] +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0060173 ! limb development + +[Term] +id: GO:0035109 +name: obsolete imaginal disc-derived limb morphogenesis +namespace: biological_process +def: "OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +comment: This term was made obsolete because the term 'limb' is not widely used in the insect community. In GO, 'limb' is used to describe the vertebrate hindlimbs and forelimbs. +synonym: "imaginal disc-derived limb morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0035114 + +[Term] +id: GO:0035110 +name: obsolete leg morphogenesis +namespace: biological_process +def: "OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf, ISBN:0198612001] +comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. +synonym: "leg morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0007480 +consider: GO:0035108 +consider: GO:0035137 + +[Term] +id: GO:0035111 +name: obsolete leg joint morphogenesis +namespace: biological_process +def: "OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur." [GOC:bf, ISBN:0582227089, PMID:12051824] +comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. +synonym: "leg joint morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0016348 +consider: GO:0036023 + +[Term] +id: GO:0035112 +name: genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal." [GOC:bf] +synonym: "genital morphogenesis" RELATED [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048806 ! genitalia development + +[Term] +id: GO:0035113 +name: embryonic appendage morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] +is_a: GO:0035107 ! appendage morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0035114 +name: imaginal disc-derived appendage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:mtg_sensu, ISBN:0582227089] +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0048737 ! imaginal disc-derived appendage development + +[Term] +id: GO:0035115 +name: embryonic forelimb morphogenesis +namespace: biological_process +alt_id: GO:0035117 +def: "The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [ISBN:0198612001] +synonym: "embryonic arm morphogenesis" NARROW [GOC:bf, GOC:cjm] +is_a: GO:0030326 ! embryonic limb morphogenesis +is_a: GO:0035136 ! forelimb morphogenesis + +[Term] +id: GO:0035116 +name: embryonic hindlimb morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal." [ISBN:0198612001] +is_a: GO:0030326 ! embryonic limb morphogenesis +is_a: GO:0035137 ! hindlimb morphogenesis + +[Term] +id: GO:0035118 +name: embryonic pectoral fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035113 ! embryonic appendage morphogenesis +is_a: GO:0035138 ! pectoral fin morphogenesis + +[Term] +id: GO:0035119 +name: embryonic pelvic fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035113 ! embryonic appendage morphogenesis +is_a: GO:0035139 ! pelvic fin morphogenesis + +[Term] +id: GO:0035120 +name: post-embryonic appendage morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [ISBN:0582227089] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0035107 ! appendage morphogenesis + +[Term] +id: GO:0035121 +name: obsolete tail morphogenesis +namespace: biological_process +def: "OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals." [ISBN:0198612001] +comment: This term was made obsolete because 'tail' has different meanings in different organisms, and is therefore not a useful grouping term. +synonym: "tail morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0003002 +consider: GO:0036342 +consider: GO:0048809 + +[Term] +id: GO:0035122 +name: embryonic medial fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "embryonic unpaired fin morphogenesis" EXACT [] +is_a: GO:0035113 ! embryonic appendage morphogenesis +is_a: GO:0035141 ! medial fin morphogenesis + +[Term] +id: GO:0035123 +name: embryonic dorsal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035142 ! dorsal fin morphogenesis + +[Term] +id: GO:0035124 +name: embryonic caudal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035143 ! caudal fin morphogenesis + +[Term] +id: GO:0035125 +name: embryonic anal fin morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035122 ! embryonic medial fin morphogenesis +is_a: GO:0035144 ! anal fin morphogenesis + +[Term] +id: GO:0035126 +name: post-embryonic genitalia morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] +synonym: "post-embryonic genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0048563 ! post-embryonic animal organ morphogenesis + +[Term] +id: GO:0035127 +name: post-embryonic limb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [ISBN:0395825172] +is_a: GO:0035108 ! limb morphogenesis +is_a: GO:0035120 ! post-embryonic appendage morphogenesis + +[Term] +id: GO:0035128 +name: post-embryonic forelimb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism." [GOC:bf] +is_a: GO:0035127 ! post-embryonic limb morphogenesis +is_a: GO:0035136 ! forelimb morphogenesis + +[Term] +id: GO:0035129 +name: post-embryonic hindlimb morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized." [GOC:bf] +is_a: GO:0035127 ! post-embryonic limb morphogenesis +is_a: GO:0035137 ! hindlimb morphogenesis + +[Term] +id: GO:0035130 +name: post-embryonic pectoral fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +is_a: GO:0035138 ! pectoral fin morphogenesis + +[Term] +id: GO:0035131 +name: post-embryonic pelvic fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +is_a: GO:0035139 ! pelvic fin morphogenesis + +[Term] +id: GO:0035132 +name: post-embryonic medial fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "post-embryonic unpaired fin morphogenesis" EXACT [] +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +is_a: GO:0035141 ! medial fin morphogenesis + +[Term] +id: GO:0035133 +name: post-embryonic caudal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035143 ! caudal fin morphogenesis + +[Term] +id: GO:0035134 +name: post-embryonic dorsal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035142 ! dorsal fin morphogenesis + +[Term] +id: GO:0035135 +name: post-embryonic anal fin morphogenesis +namespace: biological_process +def: "The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035132 ! post-embryonic medial fin morphogenesis +is_a: GO:0035144 ! anal fin morphogenesis + +[Term] +id: GO:0035136 +name: forelimb morphogenesis +namespace: biological_process +alt_id: GO:0035140 +def: "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human." [GOC:go_curators] +synonym: "arm morphogenesis" NARROW [GOC:bf, GOC:cjm] +is_a: GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0035137 +name: hindlimb morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hindlimb are generated and organized." [GOC:go_curators] +is_a: GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0035138 +name: pectoral fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0033334 ! fin morphogenesis +relationship: part_of GO:0033339 ! pectoral fin development + +[Term] +id: GO:0035139 +name: pelvic fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion." [GOC:dgh] +is_a: GO:0033334 ! fin morphogenesis +relationship: part_of GO:0033340 ! pelvic fin development + +[Term] +id: GO:0035141 +name: medial fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming." [GOC:dgh] +synonym: "median fin morphogenesis" EXACT [] +synonym: "unpaired fin morphogenesis" EXACT [] +is_a: GO:0033334 ! fin morphogenesis +relationship: part_of GO:0033338 ! medial fin development + +[Term] +id: GO:0035142 +name: dorsal fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033337 ! dorsal fin development + +[Term] +id: GO:0035143 +name: caudal fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033336 ! caudal fin development + +[Term] +id: GO:0035144 +name: anal fin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming." [GOC:dgh] +is_a: GO:0035141 ! medial fin morphogenesis +relationship: part_of GO:0033335 ! anal fin development + +[Term] +id: GO:0035145 +name: exon-exon junction complex +namespace: cellular_component +def: "A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [PMID:11532962, PMID:11743026] +synonym: "EJC" EXACT [] +synonym: "exon junction complex" EXACT [GOC:dph] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0035146 +name: tube fusion +namespace: biological_process +def: "The joining of specific branches of a tubular system to form a continuous network." [GOC:bf] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0048754 ! branching morphogenesis of an epithelial tube + +[Term] +id: GO:0035147 +name: branch fusion, open tracheal system +namespace: biological_process +def: "Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint." [GOC:mtg_sensu, PMID:14570584] +synonym: "tracheal branch fusion" EXACT [] +is_a: GO:0035146 ! tube fusion +relationship: part_of GO:0060446 ! branching involved in open tracheal system development + +[Term] +id: GO:0035148 +name: tube formation +namespace: biological_process +def: "Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow." [GOC:bf] +synonym: "lumen formation in an anatomical structure" RELATED [GOC:dph, GOC:mah] +synonym: "tube lumen formation" EXACT [GOC:dph, GOC:mah] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035239 ! tube morphogenesis + +[Term] +id: GO:0035149 +name: lumen formation, open tracheal system +namespace: biological_process +def: "Creation of the central hole of a tube in an open tracheal system through which gases flow." [GOC:bf, GOC:mtg_sensu] +synonym: "tracheal lumen formation" EXACT [] +is_a: GO:0035148 ! tube formation +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035150 +name: regulation of tube size +namespace: biological_process +def: "Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes." [PMID:10887083] +is_a: GO:0090066 ! regulation of anatomical structure size + +[Term] +id: GO:0035151 +name: regulation of tube size, open tracheal system +namespace: biological_process +def: "Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape." [GOC:mtg_sensu, PMID:10887083, PMID:12930776, PMID:12973360] +synonym: "regulation of tracheal tube size" EXACT [] +is_a: GO:0035150 ! regulation of tube size +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035152 +name: regulation of tube architecture, open tracheal system +namespace: biological_process +def: "Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network." [GOC:mtg_sensu, PMID:14570584] +synonym: "regulation of tracheal tube architecture" EXACT [] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035153 +name: epithelial cell type specification, open tracheal system +namespace: biological_process +def: "Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] +synonym: "tracheal cell type specification" BROAD [] +synonym: "tracheal epithelial cell type specification" EXACT [] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035154 +name: terminal cell fate specification, open tracheal system +namespace: biological_process +def: "The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange." [GOC:mtg_sensu, PMID:10684581, PMID:11063940] +synonym: "terminal cell fate specification" EXACT [] +is_a: GO:0035153 ! epithelial cell type specification, open tracheal system + +[Term] +id: GO:0035155 +name: negative regulation of terminal cell fate specification, open tracheal system +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [GOC:mtg_sensu, PMID:10684581] +synonym: "down regulation of terminal cell fate specification" EXACT [] +synonym: "down-regulation of terminal cell fate specification" EXACT [] +synonym: "downregulation of terminal cell fate specification" EXACT [] +synonym: "inhibition of terminal cell fate specification" NARROW [] +synonym: "negative regulation of terminal cell fate specification" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035154 ! terminal cell fate specification, open tracheal system + +[Term] +id: GO:0035156 +name: fusion cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion." [PMID:11063940] +is_a: GO:0035153 ! epithelial cell type specification, open tracheal system + +[Term] +id: GO:0035157 +name: negative regulation of fusion cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates." [PMID:10684581] +synonym: "down regulation of fusion cell fate specification" EXACT [] +synonym: "down-regulation of fusion cell fate specification" EXACT [] +synonym: "downregulation of fusion cell fate specification" EXACT [] +synonym: "inhibition of fusion cell fate specification" NARROW [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035156 ! fusion cell fate specification + +[Term] +id: GO:0035158 +name: regulation of tube diameter, open tracheal system +namespace: biological_process +def: "Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size." [GOC:mtg_sensu, PMID:14570584] +synonym: "regulation of tracheal tube diameter" EXACT [] +synonym: "tracheal tube dilation" NARROW [] +synonym: "tracheal tube expansion" NARROW [] +is_a: GO:0035159 ! regulation of tube length, open tracheal system +is_a: GO:0035296 ! regulation of tube diameter + +[Term] +id: GO:0035159 +name: regulation of tube length, open tracheal system +namespace: biological_process +def: "Ensuring that a tube in an open tracheal system is of the correct length." [GOC:bf, GOC:mtg_sensu] +synonym: "regulation of tracheal tube length" EXACT [] +synonym: "tracheal tube elongation" NARROW [] +is_a: GO:0035151 ! regulation of tube size, open tracheal system + +[Term] +id: GO:0035160 +name: maintenance of epithelial integrity, open tracheal system +namespace: biological_process +def: "Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process." [GOC:mtg_sensu, PMID:10694415, PMID:14681183] +synonym: "maintenance of tracheal epithelial integrity" EXACT [] +is_a: GO:0010669 ! epithelial structure maintenance +is_a: GO:0035152 ! regulation of tube architecture, open tracheal system + +[Term] +id: GO:0035161 +name: imaginal disc lineage restriction +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0007447 ! imaginal disc pattern formation + +[Term] +id: GO:0035162 +name: embryonic hemopoiesis +namespace: biological_process +def: "The stages of blood cell formation that take place within the embryo." [GOC:bf] +synonym: "embryonic haematopoiesis" EXACT [] +synonym: "embryonic haemopoiesis" EXACT [] +synonym: "embryonic hematopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0035163 +name: embryonic hemocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu, PMID:14602069] +synonym: "embryonic arthropod blood cell differentiation" EXACT [] +synonym: "embryonic hemocyte cell differentiation" EXACT [] +is_a: GO:0042386 ! hemocyte differentiation +relationship: part_of GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0035164 +name: embryonic plasmatocyte differentiation +namespace: biological_process +def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] +synonym: "embryonic plasmatocyte cell differentiation" EXACT [] +is_a: GO:0035163 ! embryonic hemocyte differentiation +is_a: GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0035165 +name: embryonic crystal cell differentiation +namespace: biological_process +def: "The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0035163 ! embryonic hemocyte differentiation +is_a: GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0035166 +name: post-embryonic hemopoiesis +namespace: biological_process +def: "The stages of blood cell formation that take place after completion of embryonic development." [GOC:bf] +synonym: "post-embryonic haemopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0009791 ! post-embryonic development + +[Term] +id: GO:0035167 +name: larval lymph gland hemopoiesis +namespace: biological_process +def: "The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:bf, GOC:mtg_sensu, PMID:12445385] +synonym: "larval lymph gland haematopoiesis" EXACT [] +synonym: "larval lymph gland haemopoiesis" EXACT [] +synonym: "larval lymph gland hematopoiesis" EXACT [] +is_a: GO:0035166 ! post-embryonic hemopoiesis +relationship: part_of GO:0002164 ! larval development +relationship: part_of GO:0048542 ! lymph gland development + +[Term] +id: GO:0035168 +name: larval lymph gland hemocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:14602069] +synonym: "larval lymph gland arthropod blood cell differentiation" EXACT [] +is_a: GO:0042386 ! hemocyte differentiation +relationship: part_of GO:0035167 ! larval lymph gland hemopoiesis + +[Term] +id: GO:0035169 +name: lymph gland plasmatocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte." [GOC:bf, PMID:11921077, PMID:8174791] +synonym: "lymph gland plasmatocyte cell differentiation" EXACT [] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation +is_a: GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0035170 +name: lymph gland crystal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation +is_a: GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0035171 +name: lamellocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [GOC:bf, PMID:14734104] +synonym: "lamellocyte cell differentiation" EXACT [] +is_a: GO:0035168 ! larval lymph gland hemocyte differentiation +is_a: GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0035172 +name: hemocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] +synonym: "arthropod blood cell proliferation" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0035173 +name: histone kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0035174 +name: histone serine kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] +synonym: "histone-serine kinase activity" EXACT [] +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0035175 +name: histone kinase activity (H3-S10 specific) +namespace: molecular_function +alt_id: GO:0044021 +def: "Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3." [GOC:bf, PMID:15041176] +synonym: "histone kinase activity (H3-S3 specific)" EXACT [] +synonym: "histone serine kinase activity (H3-S10 specific)" EXACT [] +synonym: "histone-serine kinase activity (H3-S10 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0035176 +name: social behavior +namespace: biological_process +def: "Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group." [GOC:jh2, PMID:12848939, Wikipedia:Social_behavior] +comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. +synonym: "cooperative behavior" RELATED [] +synonym: "social behaviour" EXACT [] +xref: Wikipedia:Social_behavior +is_a: GO:0007610 ! behavior +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms + +[Term] +id: GO:0035177 +name: larval foraging behavior +namespace: biological_process +def: "The movement of a larva through a feeding substrate whilst feeding on food." [PMID:12848927] +synonym: "larval foraging behaviour" EXACT [] +is_a: GO:0030537 ! larval behavior +is_a: GO:0060756 ! foraging behavior + +[Term] +id: GO:0035178 +name: turning behavior +namespace: biological_process +def: "Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source." [PMID:10880478] +synonym: "turning behaviour" EXACT [] +is_a: GO:0007626 ! locomotory behavior + +[Term] +id: GO:0035179 +name: larval turning behavior +namespace: biological_process +def: "Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source." [PMID:10880478] +synonym: "larval turning behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior +is_a: GO:0035178 ! turning behavior + +[Term] +id: GO:0035180 +name: larval wandering behavior +namespace: biological_process +def: "The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction." [PMID:12848927, PMID:12956960] +synonym: "larval wandering behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior + +[Term] +id: GO:0035181 +name: larval burrowing behavior +namespace: biological_process +def: "Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation." [PMID:12848927, PMID:12848939] +synonym: "larval burrowing behaviour" EXACT [] +is_a: GO:0008345 ! larval locomotory behavior + +[Term] +id: GO:0035182 +name: female germline ring canal outer rim +namespace: cellular_component +def: "An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues." [PMID:12435357, PMID:7925006] +comment: See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. +synonym: "germline ring canal outer rim" BROAD [] +synonym: "nurse cell ring canal outer rim" NARROW [] +synonym: "ovarian ring canal outer rim" NARROW [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0035324 ! female germline ring canal + +[Term] +id: GO:0035183 +name: female germline ring canal inner rim +namespace: cellular_component +def: "A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins." [PMID:10556087, PMID:7925006, PMID:9093858] +comment: See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. +synonym: "germline ring canal inner rim" BROAD [] +synonym: "nurse cell ring canal inner rim" NARROW [] +synonym: "ovarian ring canal inner rim" NARROW [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0035324 ! female germline ring canal + +[Term] +id: GO:0035184 +name: histone threonine kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] +synonym: "histone-threonine kinase activity" EXACT [] +is_a: GO:0004674 ! protein serine/threonine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0035185 +name: preblastoderm mitotic cell cycle +namespace: biological_process +def: "The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis." [ISBN:0879694238] +is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis +is_a: GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0035186 +name: syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively." [ISBN:0879694238] +is_a: GO:0033301 ! cell cycle comprising mitosis without cytokinesis +is_a: GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0035187 +name: hatching behavior +namespace: biological_process +def: "The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell." [GOC:pr, PMID:10436051] +synonym: "hatching behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0035188 ! hatching + +[Term] +id: GO:0035188 +name: hatching +namespace: biological_process +def: "The emergence of an immature organism from a protective structure." [GOC:dgh, GOC:isa_complete, ISBN:0198612001] +is_a: GO:0071684 ! organism emergence from protective structure +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0035189 +name: Rb-E2F complex +namespace: cellular_component +def: "A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression." [PMID:14616073] +synonym: "retinoblastoma-E2F complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0035190 +name: syncytial nuclear migration +namespace: biological_process +def: "The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex." [GOC:bf, ISBN:0879694238, PMID:8314839] +is_a: GO:0007097 ! nuclear migration +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0035191 +name: nuclear axial expansion +namespace: biological_process +def: "The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex." [PMID:8314839] +synonym: "nuclear distribution along anterior-posterior axis" EXACT [] +synonym: "nucleus distribution along anterior-posterior axis" EXACT [] +is_a: GO:0035190 ! syncytial nuclear migration + +[Term] +id: GO:0035192 +name: nuclear cortical migration +namespace: biological_process +def: "The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo." [PMID:8314839] +is_a: GO:0035190 ! syncytial nuclear migration + +[Term] +id: GO:0035193 +name: larval central nervous system remodeling +namespace: biological_process +def: "Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster." [GOC:sensu, PMID:9647692] +synonym: "central nervous system metamorphosis" EXACT [] +synonym: "CNS metamorphosis" EXACT [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0002165 ! instar larval or pupal development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0035194 +name: post-transcriptional gene silencing by RNA +namespace: biological_process +def: "Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation." [GOC:aruk, GOC:bc, GOC:mah, GOC:rl, PMID:15020054, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604] +synonym: "posttranscriptional gene silencing by RNA" EXACT [] +synonym: "RNA-mediated posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] +synonym: "sense-PTGS" RELATED [] +is_a: GO:0016441 ! posttranscriptional gene silencing +is_a: GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0035195 +name: gene silencing by miRNA +namespace: biological_process +def: "Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604] +synonym: "gene silencing by microRNA" EXACT [GOC:pr] +synonym: "microRNA-mediated gene silencing" EXACT [] +synonym: "miRNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] +is_a: GO:0035194 ! post-transcriptional gene silencing by RNA + +[Term] +id: GO:0035196 +name: production of miRNAs involved in gene silencing by miRNA +namespace: biological_process +alt_id: GO:0030918 +def: "Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:15066275, PMID:15066283, PMID:23985560, PMID:28379604] +synonym: "gene silencing by miRNA, production of miRNAs" EXACT [GOC:mah] +synonym: "microRNA biogenesis" RELATED [GOC:tb] +synonym: "microRNA biosynthesis" RELATED [] +synonym: "microRNA biosynthetic process" RELATED [] +synonym: "microRNA metabolic process" RELATED [] +synonym: "microRNA metabolism" RELATED [] +synonym: "microRNA processing" BROAD [] +synonym: "microRNA-mediated gene silencing, production of microRNAs" EXACT [] +synonym: "miRNA biogenesis" RELATED [GOC:tb] +synonym: "miRNA biosynthetic process" EXACT [] +synonym: "miRNA processing" EXACT [] +synonym: "miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:dph, GOC:tb] +synonym: "production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:pr] +is_a: GO:0070918 ! primary sncRNA processing +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035197 +name: siRNA binding +namespace: molecular_function +def: "Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." [PMID:15066275, PMID:15066283] +synonym: "small interfering RNA binding" EXACT [] +is_a: GO:0061980 ! regulatory RNA binding + +[Term] +id: GO:0035198 +name: miRNA binding +namespace: molecular_function +def: "Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes." [PMID:15066283] +synonym: "microRNA binding" EXACT [] +is_a: GO:0061980 ! regulatory RNA binding + +[Term] +id: GO:0035199 +name: salt aversion +namespace: biological_process +def: "The specific avoidance actions or reactions of an organism in response to the perception of salt." [GOC:bf] +synonym: "behavioral response to salt" BROAD [] +is_a: GO:0007631 ! feeding behavior +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0035200 +name: leg disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc." [GOC:bf] +is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc +is_a: GO:0035223 ! leg disc pattern formation + +[Term] +id: GO:0035201 +name: leg disc anterior/posterior lineage restriction +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf] +is_a: GO:0048099 ! anterior/posterior lineage restriction, imaginal disc +relationship: part_of GO:0035200 ! leg disc anterior/posterior pattern formation + +[Term] +id: GO:0035202 +name: tracheal pit formation in open tracheal system +namespace: biological_process +def: "Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940, PMID:11992723, PMID:14570584] +synonym: "tracheal placode invagination" RELATED [] +synonym: "tracheal sac formation" BROAD [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035203 +name: regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +is_a: GO:0045613 ! regulation of plasmatocyte differentiation +is_a: GO:1903706 ! regulation of hemopoiesis +relationship: regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035204 +name: negative regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +synonym: "down regulation of lamellocyte differentiation" EXACT [] +synonym: "down-regulation of lamellocyte differentiation" EXACT [] +synonym: "downregulation of lamellocyte differentiation" EXACT [] +synonym: "inhibition of lamellocyte differentiation" NARROW [] +is_a: GO:0035203 ! regulation of lamellocyte differentiation +is_a: GO:0045614 ! negative regulation of plasmatocyte differentiation +relationship: negatively_regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035205 +name: positive regulation of lamellocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes." [PMID:14734104] +synonym: "activation of lamellocyte differentiation" NARROW [] +synonym: "stimulation of lamellocyte differentiation" NARROW [] +synonym: "up regulation of lamellocyte differentiation" EXACT [] +synonym: "up-regulation of lamellocyte differentiation" EXACT [] +synonym: "upregulation of lamellocyte differentiation" EXACT [] +is_a: GO:0035203 ! regulation of lamellocyte differentiation +is_a: GO:0045615 ! positive regulation of plasmatocyte differentiation +relationship: positively_regulates GO:0035171 ! lamellocyte differentiation + +[Term] +id: GO:0035206 +name: regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "regulation of arthropod blood cell proliferation" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035207 +name: negative regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "down regulation of hemocyte proliferation" EXACT [] +synonym: "down-regulation of hemocyte proliferation" EXACT [] +synonym: "downregulation of hemocyte proliferation" EXACT [] +synonym: "inhibition of hemocyte proliferation" NARROW [] +synonym: "negative regulation of arthropod blood cell proliferation" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0035206 ! regulation of hemocyte proliferation +relationship: negatively_regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035208 +name: positive regulation of hemocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "activation of hemocyte proliferation" NARROW [] +synonym: "positive regulation of arthropod blood cell proliferation" EXACT [] +synonym: "stimulation of hemocyte proliferation" NARROW [] +synonym: "up regulation of hemocyte proliferation" EXACT [] +synonym: "up-regulation of hemocyte proliferation" EXACT [] +synonym: "upregulation of hemocyte proliferation" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0035206 ! regulation of hemocyte proliferation +relationship: positively_regulates GO:0035172 ! hemocyte proliferation + +[Term] +id: GO:0035209 +name: pupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0035210 +name: prepupal development +namespace: biological_process +def: "The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation." [GOC:mtg_sensu, http://sdb.bio.purdue.edu/fly/aimain/1adult.htm] +comment: See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'. +is_a: GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0035211 +name: spermathecum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk." [PMID:12679097] +comment: See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'. +is_a: GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0035212 +name: cell competition in a multicellular organism +namespace: biological_process +def: "Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells." [GOC:bf, PMID:1116643, PMID:15066286] +is_a: GO:0009987 ! cellular process +is_a: GO:0040008 ! regulation of growth +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0035213 +name: clypeo-labral disc development +namespace: biological_process +def: "The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite." [GOC:bf, ISBN:0879694238] +synonym: "development of structures derived from the clypeo-labral disc" EXACT [] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035214 +name: eye-antennal disc development +namespace: biological_process +def: "Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035215 +name: genital disc development +namespace: biological_process +def: "Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia." [GOC:bf, ISBN:0879694238, PMID:11494318] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035216 +name: haltere disc development +namespace: biological_process +def: "Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035217 +name: labial disc development +namespace: biological_process +def: "Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035218 +name: leg disc development +namespace: biological_process +def: "Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035219 +name: prothoracic disc development +namespace: biological_process +def: "Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035220 +name: wing disc development +namespace: biological_process +def: "Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] +is_a: GO:0007444 ! imaginal disc development + +[Term] +id: GO:0035221 +name: genital disc pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035222 +name: wing disc pattern formation +namespace: biological_process +def: "The process giving rise to the pattern of cell differentiation in the wing imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0035223 +name: leg disc pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation in the leg imaginal disc." [GOC:bf] +is_a: GO:0007447 ! imaginal disc pattern formation +relationship: part_of GO:0035218 ! leg disc development + +[Term] +id: GO:0035224 +name: genital disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium)." [PMID:11494318] +is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc +is_a: GO:0035221 ! genital disc pattern formation + +[Term] +id: GO:0035225 +name: determination of genital disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two." [GOC:bf, PMID:11494318] +is_a: GO:0007445 ! determination of imaginal disc primordium +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035226 +name: glutamate-cysteine ligase catalytic subunit binding +namespace: molecular_function +def: "Binding to the catalytic subunit of glutamate-cysteine ligase." [PMID:12954617] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035227 +name: regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that modulates the activity of glutamate-cysteine ligase." [GOC:bf] +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0035228 +name: negative regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase." [GOC:bf] +synonym: "down regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "down-regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "downregulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "inhibition of glutamate-cysteine ligase activity" NARROW [] +is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity +is_a: GO:0051352 ! negative regulation of ligase activity + +[Term] +id: GO:0035229 +name: positive regulation of glutamate-cysteine ligase activity +namespace: biological_process +def: "Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate." [PMID:12954617] +synonym: "activation of glutamate-cysteine ligase activity" NARROW [] +synonym: "stimulation of glutamate-cysteine ligase activity" NARROW [] +synonym: "up regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "up-regulation of glutamate-cysteine ligase activity" EXACT [] +synonym: "upregulation of glutamate-cysteine ligase activity" EXACT [] +is_a: GO:0035227 ! regulation of glutamate-cysteine ligase activity +is_a: GO:0051351 ! positive regulation of ligase activity + +[Term] +id: GO:0035230 +name: cytoneme +namespace: cellular_component +def: "A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um." [PMID:10367889, PMID:10675901] +subset: goslim_pir +synonym: "membrane nanotube" EXACT [Wikipedia:Membrane_nanotube] +xref: Wikipedia:Membrane_nanotube +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0035231 +name: cytoneme assembly +namespace: biological_process +def: "Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [PMID:10367889, PMID:10675901] +synonym: "cytoneme biogenesis" RELATED [GOC:mah] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly +relationship: part_of GO:0003399 ! cytoneme morphogenesis + +[Term] +id: GO:0035232 +name: germ cell attraction +namespace: biological_process +def: "The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target." [PMID:12885551] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0050918 ! positive chemotaxis +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0008354 ! germ cell migration + +[Term] +id: GO:0035233 +name: germ cell repulsion +namespace: biological_process +def: "The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue." [PMID:12885551] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0050919 ! negative chemotaxis +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0008354 ! germ cell migration + +[Term] +id: GO:0035234 +name: ectopic germ cell programmed cell death +namespace: biological_process +def: "Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo." [PMID:12814944] +synonym: "programmed cell death of ectopic germ cells" EXACT [] +synonym: "programmed cell death, ectopic germ cells" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010623 ! programmed cell death involved in cell development + +[Term] +id: GO:0035235 +name: ionotropic glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0198506732] +synonym: "ionotropic glutamate receptor signalling pathway" EXACT [] +is_a: GO:0007215 ! glutamate receptor signaling pathway +is_a: GO:1990806 ! ligand-gated ion channel signaling pathway + +[Term] +id: GO:0035236 +name: proctolin receptor activity +namespace: molecular_function +def: "Combining with the neuropeptide proctolin, to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0035237 +name: corazonin receptor activity +namespace: molecular_function +def: "Combining with the neuropeptide corazonin to initiate a change in cell activity." [GOC:bf] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0035238 +name: vitamin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids." [PMID:11158606] +synonym: "vitamin A anabolism" EXACT [] +synonym: "vitamin A biosynthesis" EXACT [] +synonym: "vitamin A formation" EXACT [] +synonym: "vitamin A synthesis" EXACT [] +is_a: GO:0006776 ! vitamin A metabolic process +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process + +[Term] +id: GO:0035239 +name: tube morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:bf, PMID:14624839] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035295 ! tube development + +[Term] +id: GO:0035240 +name: dopamine binding +namespace: molecular_function +def: "Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine." [ISBN:0198506732] +is_a: GO:0043169 ! cation binding +is_a: GO:1901338 ! catecholamine binding + +[Term] +id: GO:0035241 +name: protein-arginine omega-N monomethyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine." [EC:2.1.1.321, PMID:14705965, RESID:AA0069] +comment: Type III protein arginine methyltransferases catalyze the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyze this reaction, type III enzymes do not methylate the substrate any further. +synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)" RELATED [EC:2.1.1.321] +synonym: "type III protein arginine methyltransferase activity" RELATED [EC:2.1.1.321] +xref: EC:2.1.1.321 +xref: RESID:AA0069 +xref: RHEA:48100 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035242 +name: protein-arginine omega-N asymmetric methyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues." [PMID:14705965, RESID:AA0068, RESID:AA0069, RHEA:48096] +comment: Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. +synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.319] +synonym: "type I PRMT activity" RELATED [] +synonym: "type I protein arginine methyltransferase activity" RELATED [EC:2.1.1.319] +xref: EC:2.1.1.319 +xref: RESID:AA0068 +xref: RESID:AA0069 +xref: RHEA:48096 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035243 +name: protein-arginine omega-N symmetric methyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues." [EC:2.1.1.320, PMID:14705965, RESID:AA0067, RESID:AA0069] +comment: Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. +synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming)" RELATED [EC:2.1.1.320] +synonym: "type II PRMT activity" RELATED [] +synonym: "type II protein arginine methyltransferase activity" RELATED [] +xref: EC:2.1.1.320 +xref: Reactome:R-HSA-6804383 "PRMT5 methylates TP53" +xref: RESID:AA0067 +xref: RESID:AA0069 +xref: RHEA:48108 +is_a: GO:0016274 ! protein-arginine N-methyltransferase activity + +[Term] +id: GO:0035244 +name: peptidyl-arginine C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein." [GOC:bf] +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0035245 +name: peptidyl-arginine C-methylation +namespace: biological_process +def: "The addition of a methyl group onto a carbon atom of an arginine residue in a protein." [GOC:bf] +is_a: GO:0018216 ! peptidyl-arginine methylation + +[Term] +id: GO:0035246 +name: peptidyl-arginine N-methylation +namespace: biological_process +def: "The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein." [GOC:bf] +is_a: GO:0018216 ! peptidyl-arginine methylation + +[Term] +id: GO:0035247 +name: peptidyl-arginine omega-N-methylation +namespace: biological_process +def: "The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein." [PMID:14705965, RESID:AA0067, RESID:AA0068, RESID:AA0069] +xref: RESID:AA0067 +xref: RESID:AA0068 +xref: RESID:AA0069 +is_a: GO:0035246 ! peptidyl-arginine N-methylation + +[Term] +id: GO:0035248 +name: alpha-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage." [PMID:15130086] +synonym: "alpha-1,4-GalNAc transferase activity" EXACT [] +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0035249 +name: synaptic transmission, glutamatergic +namespace: biological_process +def: "The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] +synonym: "glutamatergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0035250 +name: UDP-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule." [PMID:19858195] +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0035251 +name: UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [PMID:19858195] +xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-1912353 "Glucosylation of Pre-NOTCH by POGLUT1" +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0035252 +name: UDP-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule." [PMID:30127001] +xref: Reactome:R-HSA-5617138 "B4GAT1:GYLTL1B transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA" +xref: Reactome:R-HSA-6785668 "Defective LARGE does not transfer Xyl from UDP-Xyl to GlcA" +xref: Reactome:R-HSA-9638090 "B4GAT1:LARGE transfers Xyl from UDP-Xyl to GlcA-Xyl-GlcA" +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0035253 +name: ciliary rootlet +namespace: cellular_component +def: "A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm." [GOC:cilia, PMID:12427867] +synonym: "cilial rootlet" EXACT [] +synonym: "cilium rootlet" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0035254 +name: glutamate receptor binding +namespace: molecular_function +def: "Binding to a glutamate receptor." [GOC:bf] +subset: goslim_chembl +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0035255 +name: ionotropic glutamate receptor binding +namespace: molecular_function +def: "Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels." [GOC:bf, ISBN:0198506732] +is_a: GO:0035254 ! glutamate receptor binding + +[Term] +id: GO:0035256 +name: G protein-coupled glutamate receptor binding +namespace: molecular_function +def: "Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor)." [GOC:bf, ISBN:0198506732, PMID:9069287] +synonym: "G-protein coupled glutamate receptor binding" EXACT [] +synonym: "metabotropic glutamate receptor binding" EXACT [GOC:bf] +is_a: GO:0001664 ! G protein-coupled receptor binding +is_a: GO:0035254 ! glutamate receptor binding + +[Term] +id: GO:0035259 +name: glucocorticoid receptor binding +namespace: molecular_function +def: "Binding to a glucocorticoid receptor." [GOC:bf] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0035260 +name: internal genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals." [http://www.ndif.org/Terms/genitalia.html] +is_a: GO:0035112 ! genitalia morphogenesis + +[Term] +id: GO:0035261 +name: external genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals." [http://www.ndif.org/Terms/genitalia.html] +is_a: GO:0035112 ! genitalia morphogenesis + +[Term] +id: GO:0035262 +name: gonad morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals." [ISBN:0198612001] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0008406 ! gonad development + +[Term] +id: GO:0035263 +name: genital disc sexually dimorphic development +namespace: biological_process +def: "The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed." [PMID:11290302, PMID:11494318, PMID:11702781] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007548 ! sex differentiation +relationship: part_of GO:0035215 ! genital disc development + +[Term] +id: GO:0035264 +name: multicellular organism growth +namespace: biological_process +def: "The increase in size or mass of an entire multicellular organism, as opposed to cell growth." [GOC:bf, GOC:curators, GOC:dph, GOC:tb] +synonym: "body growth" RELATED [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0035265 +name: organ growth +namespace: biological_process +def: "The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function." [GOC:bf, ISBN:0471245208, ISBN:0721662544] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0035266 +name: meristem growth +namespace: biological_process +def: "The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:bf, ISBN:0198547684] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048507 ! meristem development + +[Term] +id: GO:0035267 +name: NuA4 histone acetyltransferase complex +namespace: cellular_component +def: "A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60)." [GOC:ecd, PMID:10966108, PMID:14966270] +synonym: "TIP60 histone acetylase complex" EXACT [] +synonym: "TIP60 histone acetyltransferase complex" EXACT [] +is_a: GO:0043189 ! H4/H2A histone acetyltransferase complex + +[Term] +id: GO:0035268 +name: protein mannosylation +namespace: biological_process +def: "The addition of a mannose residue to a protein acceptor molecule." [GOC:bf, GOC:pr] +synonym: "protein amino acid mannosylation" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation +is_a: GO:0097502 ! mannosylation + +[Term] +id: GO:0035269 +name: protein O-linked mannosylation +namespace: biological_process +def: "The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:bf, PMID:9878797] +synonym: "protein amino acid O-linked mannosylation" EXACT [GOC:bf] +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0035268 ! protein mannosylation + +[Term] +id: GO:0035270 +name: endocrine system development +namespace: biological_process +def: "Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes." [GOC:bf, Wikipedia:Development_of_the_endocrine_system] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0035271 +name: ring gland development +namespace: biological_process +def: "Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones." [GOC:bf, PMID:11223816, PMID:9584098] +comment: See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799. +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0035272 +name: exocrine system development +namespace: biological_process +def: "Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system." [GOC:bf, Wikipedia:Exocrine_gland] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0035273 +name: phthalate binding +namespace: molecular_function +def: "Binding to a phthalate, any ester or salt of phthalic acid." [http://umbbd.ahc.umn.edu/pth/pth_map.html] +subset: goslim_pir +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0035274 +name: diphenyl phthalate binding +namespace: molecular_function +def: "Binding to diphenyl phthalate, C(20)H(14)O(4)." [http://www.sigmaaldrich.com] +synonym: "DPP binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0035275 +name: dibutyl phthalate binding +namespace: molecular_function +def: "Binding to dibutyl phthalate, C(16)H(22)O(4)." [http://www.sigmaaldrich.com] +synonym: "DBP binding" EXACT [] +synonym: "phthalic acid dibutyl ester binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0035276 +name: ethanol binding +namespace: molecular_function +def: "Binding to ethanol, CH(3)-CH(2)-OH." [ISBN:0198506732] +is_a: GO:0043168 ! anion binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0035277 +name: spiracle morphogenesis, open tracheal system +namespace: biological_process +def: "The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk." [GOC:mtg_sensu, PMID:10491268] +synonym: "spiracle morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0035278 +name: miRNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs." [PMID:14744438, PMID:15196554] +synonym: "down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] +synonym: "down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] +synonym: "downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:mah] +synonym: "gene silencing by miRNA, negative regulation of translation" EXACT [GOC:mah] +synonym: "inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:mah] +synonym: "miRNA mediated inhibition of translation" EXACT [] +synonym: "miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:pr] +is_a: GO:0035195 ! gene silencing by miRNA +is_a: GO:0040033 ! RNA-mediated gene silencing by inhibition of translation + +[Term] +id: GO:0035279 +name: miRNA-mediated gene silencing by mRNA destabilization +namespace: biological_process +def: "The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554] +synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah] +synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb] +synonym: "mRNA cleavage involved in gene silencing by microRNA" EXACT [GOC:pr] +synonym: "mRNA cleavage involved in gene silencing by miRNA" EXACT [] +synonym: "mRNA destabilization-mediated gene silencing by miRNA" EXACT [] +is_a: GO:0035195 ! gene silencing by miRNA +is_a: GO:0098795 ! mRNA destabilization-mediated gene silencing + +[Term] +id: GO:0035280 +name: miRNA loading onto RISC +namespace: biological_process +def: "The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC)." [PMID:14744438] +synonym: "gene silencing by miRNA, miRNA loading onto RISC" EXACT [GOC:mah] +synonym: "microRNA loading onto RISC involved in gene silencing by microRNA" EXACT [GOC:pr] +synonym: "miRISC assembly" BROAD [] +synonym: "miRNA loading onto RISC involved in gene silencing by miRNA" EXACT [] +synonym: "miRNA-mediated gene silencing, miRNA loading onto RISC" EXACT [GOC:dph, GOC:tb] +is_a: GO:0070922 ! small RNA loading onto RISC +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035281 +name: pre-miRNA export from nucleus +namespace: biological_process +def: "Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product." [GOC:sl, PMID:14744438] +synonym: "pre-microRNA export from cell nucleus" EXACT [] +synonym: "pre-microRNA export from nucleus" RELATED [] +synonym: "pre-microRNA export out of nucleus" EXACT [] +synonym: "pre-microRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "pre-microRNA-nucleus export" EXACT [] +is_a: GO:0006405 ! RNA export from nucleus +relationship: part_of GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0035282 +name: segmentation +namespace: biological_process +def: "The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis." [PMID:10611687, PMID:9706689] +xref: Wikipedia:Segmentation_(biology) +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0035283 +name: central nervous system segmentation +namespace: biological_process +def: "Division of the central nervous system into a series of semi-repetitive parts or segments." [GOC:bf] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0035284 +name: brain segmentation +namespace: biological_process +def: "Division of the brain into a series of semi-repetitive parts or segments." [GOC:bf] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007420 ! brain development +relationship: part_of GO:0035283 ! central nervous system segmentation + +[Term] +id: GO:0035285 +name: appendage segmentation +namespace: biological_process +def: "Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented." [PMID:10357895] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0035107 ! appendage morphogenesis + +[Term] +id: GO:0035286 +name: obsolete leg segmentation +namespace: biological_process +def: "OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint." [PMID:10357895] +comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. +synonym: "leg segmentation" EXACT [] +is_obsolete: true +consider: GO:0035285 +consider: GO:0036011 + +[Term] +id: GO:0035287 +name: head segmentation +namespace: biological_process +def: "Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial)." [PMID:10477305, PMID:7915837] +comment: See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children. +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0007350 ! blastoderm segmentation +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0035288 +name: anterior head segmentation +namespace: biological_process +def: "Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments." [PMID:15382136] +comment: See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children. +synonym: "procephalic segmentation" RELATED [] +is_a: GO:0035287 ! head segmentation +relationship: part_of GO:0097065 ! anterior head development + +[Term] +id: GO:0035289 +name: posterior head segmentation +namespace: biological_process +def: "Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains." [PMID:15382136] +comment: See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children. +synonym: "gnathal segmentation" RELATED [] +is_a: GO:0035287 ! head segmentation + +[Term] +id: GO:0035290 +name: trunk segmentation +namespace: biological_process +def: "Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8." [PMID:1360402] +is_a: GO:0035282 ! segmentation +relationship: part_of GO:0007350 ! blastoderm segmentation + +[Term] +id: GO:0035291 +name: specification of segmental identity, intercalary segment +namespace: biological_process +def: "The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437, PMID:10477305] +comment: See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035288 ! anterior head segmentation + +[Term] +id: GO:0035292 +name: specification of segmental identity, trunk +namespace: biological_process +def: "The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [PMID:1360402] +is_a: GO:0007379 ! segment specification +relationship: part_of GO:0035290 ! trunk segmentation + +[Term] +id: GO:0035293 +name: chitin-based larval cuticle pattern formation +namespace: biological_process +def: "The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +is_a: GO:0035017 ! cuticle pattern formation +relationship: part_of GO:0008363 ! larval chitin-based cuticle development + +[Term] +id: GO:0035294 +name: determination of wing disc primordium +namespace: biological_process +def: "Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc." [ISBN:0879694238] +is_a: GO:0007445 ! determination of imaginal disc primordium +is_a: GO:0035220 ! wing disc development + +[Term] +id: GO:0035295 +name: tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts." [PMID:12526790] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0035296 +name: regulation of tube diameter +namespace: biological_process +def: "Any process that modulates the diameter of a tube." [GOC:bf] +is_a: GO:0035150 ! regulation of tube size + +[Term] +id: GO:0035297 +name: regulation of Malpighian tubule diameter +namespace: biological_process +def: "Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells." [PMID:9286684] +is_a: GO:0035296 ! regulation of tube diameter +is_a: GO:0035298 ! regulation of Malpighian tubule size + +[Term] +id: GO:0035298 +name: regulation of Malpighian tubule size +namespace: biological_process +def: "Ensuring that a Malpighian tubule is the correct length and diameter." [GOC:bf] +is_a: GO:0035150 ! regulation of tube size +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0035299 +name: inositol pentakisphosphate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+)." [RHEA:20313] +synonym: "ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity" RELATED [EC:2.7.1.158] +synonym: "Gsl1p" RELATED [EC:2.7.1.158] +synonym: "inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity" RELATED [EC:2.7.1.158] +synonym: "inositol hexakisphosphate synthase" RELATED [] +synonym: "inositol polyphosphate kinase activity" RELATED [EC:2.7.1.158] +synonym: "inositol-pentakisphosphate 2-kinase activity" RELATED [EC:2.7.1.158] +synonym: "Ins(1,3,4,5,6)P5 2-kinase activity" RELATED [EC:2.7.1.158] +synonym: "IP5 2-kinase activity" RELATED [EC:2.7.1.158] +synonym: "Ipk1p" RELATED [EC:2.7.1.158] +xref: EC:2.7.1.158 +xref: KEGG_REACTION:R05202 +xref: MetaCyc:RXN-7163 +xref: Reactome:R-HSA-1855176 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus" +xref: Reactome:R-HSA-1855179 "I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol" +xref: RHEA:20313 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0035300 +name: obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate." [EC:2.7.1.159, PMID:9126335] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.159] +synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" NARROW [] +synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" NARROW [] +synonym: "inositol trisphosphate 5/6-kinase activity" RELATED [EC:2.7.1.159] +synonym: "inositol-1,3,4-trisphosphate 5/6-kinase activity" EXACT [] +synonym: "Ins(1,3,4)P3 5/6-kinase activity" RELATED [EC:2.7.1.159] +synonym: "IP56K" RELATED [EC:2.7.1.159] +is_obsolete: true +consider: GO:0052725 +consider: GO:0052726 + +[Term] +id: GO:0035301 +name: Hedgehog signaling complex +namespace: cellular_component +def: "A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila)." [PMID:10825151, PMID:15057936] +synonym: "Hedgehog signalling complex" EXACT [] +synonym: "HSC" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0035302 +name: ecdysteroid 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods." [ISBN:0198506732, PMID:15350618] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0035303 +name: regulation of dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035304 +name: regulation of protein dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +synonym: "regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0035303 ! regulation of dephosphorylation +relationship: regulates GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035305 +name: negative regulation of dephosphorylation +namespace: biological_process +def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +synonym: "down regulation of dephosphorylation" EXACT [] +synonym: "down-regulation of dephosphorylation" EXACT [] +synonym: "downregulation of dephosphorylation" EXACT [] +synonym: "inhibition of dephosphorylation" NARROW [] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +relationship: negatively_regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035306 +name: positive regulation of dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule." [GOC:bf] +synonym: "activation of dephosphorylation" NARROW [] +synonym: "stimulation of dephosphorylation" NARROW [] +synonym: "up regulation of dephosphorylation" EXACT [] +synonym: "up-regulation of dephosphorylation" EXACT [] +synonym: "upregulation of dephosphorylation" EXACT [] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +relationship: positively_regulates GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035307 +name: positive regulation of protein dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +synonym: "activation of protein amino acid dephosphorylation" NARROW [] +synonym: "positive regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] +synonym: "stimulation of protein amino acid dephosphorylation" NARROW [] +synonym: "up regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "up-regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "upregulation of protein amino acid dephosphorylation" EXACT [] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0035304 ! regulation of protein dephosphorylation +is_a: GO:0035306 ! positive regulation of dephosphorylation +relationship: positively_regulates GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035308 +name: negative regulation of protein dephosphorylation +namespace: biological_process +def: "Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein." [GOC:bf] +synonym: "down regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "down-regulation of protein amino acid dephosphorylation" EXACT [] +synonym: "downregulation of protein amino acid dephosphorylation" EXACT [] +synonym: "inhibition of protein amino acid dephosphorylation" NARROW [] +synonym: "negative regulation of protein amino acid dephosphorylation" EXACT [GOC:bf] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0035304 ! regulation of protein dephosphorylation +is_a: GO:0035305 ! negative regulation of dephosphorylation +relationship: negatively_regulates GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035309 +name: wing and notum subfield formation +namespace: biological_process +def: "The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures." [PMID:10860999] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0035220 ! wing disc development + +[Term] +id: GO:0035310 +name: notum cell fate specification +namespace: biological_process +def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment." [PMID:10860999] +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0035309 ! wing and notum subfield formation + +[Term] +id: GO:0035311 +name: wing cell fate specification +namespace: biological_process +def: "The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment." [PMID:10860999] +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0035309 ! wing and notum subfield formation + +[Term] +id: GO:0035312 +name: 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] +is_a: GO:0008409 ! 5'-3' exonuclease activity +is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0035313 +name: wound healing, spreading of epidermal cells +namespace: biological_process +def: "The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis." [GOC:bf, PMID:15269788] +is_a: GO:0044319 ! wound healing, spreading of cells + +[Term] +id: GO:0035314 +name: scab formation +namespace: biological_process +def: "Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection." [GOC:bf, PMID:15269788] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0035315 +name: hair cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hair cell." [GOC:bf] +is_a: GO:0009913 ! epidermal cell differentiation +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0035316 +name: non-sensory hair organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis." [GOC:mtg_sensu, PMID:11064425] +comment: See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. +synonym: "non-sensory hair organization and biogenesis" RELATED [GOC:mah] +synonym: "trichome organisation" BROAD [] +synonym: "trichome organization and biogenesis" BROAD [] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization +relationship: part_of GO:0035315 ! hair cell differentiation + +[Term] +id: GO:0035317 +name: imaginal disc-derived wing hair organization +namespace: biological_process +def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11064425, PMID:12540853] +comment: See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'. +synonym: "imaginal disc-derived wing hair organization and biogenesis" RELATED [GOC:mah] +synonym: "wing hair organisation" EXACT [] +synonym: "wing hair organization and biogenesis" RELATED [GOC:mah] +synonym: "wing trichome organization and biogenesis" EXACT [] +is_a: GO:0035316 ! non-sensory hair organization +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0035318 +name: imaginal disc-derived wing hair outgrowth +namespace: biological_process +def: "Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair." [GOC:mtg_sensu, PMID:11064425, PMID:8947551] +synonym: "wing hair outgrowth" EXACT [] +synonym: "wing prehair outgrowth" RELATED [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0048858 ! cell projection morphogenesis +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0035319 +name: imaginal disc-derived wing hair elongation +namespace: biological_process +def: "Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles." [GOC:mtg_sensu, PMID:11832234] +synonym: "wing hair elongation" EXACT [] +synonym: "wing prehair extension" RELATED [] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0048858 ! cell projection morphogenesis +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0035320 +name: imaginal disc-derived wing hair site selection +namespace: biological_process +def: "Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally." [GOC:mtg_transport, ISBN:0815340729, PMID:8947551] +synonym: "prehair localization" RELATED [] +synonym: "wing hair site selection" EXACT [] +is_a: GO:0022606 ! establishment of proximal/distal cell polarity +relationship: part_of GO:0001737 ! establishment of imaginal disc-derived wing hair orientation + +[Term] +id: GO:0035321 +name: maintenance of imaginal disc-derived wing hair orientation +namespace: biological_process +def: "Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity." [GOC:mtg_sensu, PMID:15501220] +synonym: "maintenance of wing hair orientation" EXACT [] +is_a: GO:0009954 ! proximal/distal pattern formation +relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization + +[Term] +id: GO:0035322 +name: mesenchymal cell migration involved in limb bud formation +namespace: biological_process +def: "The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud." [GOC:dgh] +is_a: GO:0090497 ! mesenchymal cell migration +relationship: part_of GO:0090496 ! mesenchyme migration involved in limb bud formation + +[Term] +id: GO:0035323 +name: male germline ring canal +namespace: cellular_component +def: "An intercellular bridge that connects the germline cells of a male cyst." [PMID:9635420] +synonym: "spermatocyte ring canal" NARROW [] +synonym: "testicular ring canal" NARROW [] +is_a: GO:0045172 ! germline ring canal + +[Term] +id: GO:0035324 +name: female germline ring canal +namespace: cellular_component +def: "An intercellular bridge that connects the germline cells of a female cyst." [PMID:9635420] +synonym: "nurse cell ring canal" NARROW [] +synonym: "ovarian ring canal" NARROW [] +is_a: GO:0045172 ! germline ring canal + +[Term] +id: GO:0035325 +name: Toll-like receptor binding +namespace: molecular_function +def: "Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response." [PMID:19076341] +synonym: "TLR binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0035329 +name: hippo signaling +namespace: biological_process +def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423] +synonym: "hippo signal transduction" EXACT [GOC:signaling] +synonym: "hippo signaling cascade" RELATED [GOC:signaling] +synonym: "hippo signaling pathway" EXACT [] +synonym: "hippo signalling cascade" RELATED [GOC:mah] +synonym: "Salvador-Warts-Hippo signaling pathway" NARROW [] +synonym: "SWH pathway" NARROW [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0035330 +name: regulation of hippo signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hippo signaling." [GOC:bf] +synonym: "regulation of hippo signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of hippo signaling pathway" EXACT [] +synonym: "regulation of hippo signalling cascade" RELATED [GOC:mah] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0035329 ! hippo signaling + +[Term] +id: GO:0035331 +name: negative regulation of hippo signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling." [GOC:bf] +synonym: "negative regulation of hippo signaling cascade" RELATED [GOC:signaling] +synonym: "negative regulation of hippo signaling pathway" EXACT [] +synonym: "negative regulation of hippo signalling cascade" RELATED [GOC:mah] +is_a: GO:0035330 ! regulation of hippo signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0035329 ! hippo signaling + +[Term] +id: GO:0035332 +name: positive regulation of hippo signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hippo signaling." [GOC:bf] +synonym: "positive regulation of hippo signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of hippo signaling pathway" EXACT [] +synonym: "positive regulation of hippo signalling cascade" RELATED [GOC:mah] +is_a: GO:0035330 ! regulation of hippo signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0035329 ! hippo signaling + +[Term] +id: GO:0035333 +name: Notch receptor processing, ligand-dependent +namespace: biological_process +def: "The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD)." [GOC:bf, PMID:12651094] +synonym: "Notch S2 cleavage" NARROW [PMID:12651094] +synonym: "Notch S3 cleavage" NARROW [PMID:12651094] +is_a: GO:0031293 ! membrane protein intracellular domain proteolysis +relationship: part_of GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0007220 ! Notch receptor processing + +[Term] +id: GO:0035334 +name: Notch receptor processing, ligand-independent +namespace: biological_process +def: "The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface." [GOC:bf, PMID:12651094] +synonym: "Notch S1 cleavage" NARROW [PMID:12651094] +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0007220 ! Notch receptor processing + +[Term] +id: GO:0035335 +name: peptidyl-tyrosine dephosphorylation +namespace: biological_process +def: "The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." [GOC:bf] +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035336 +name: long-chain fatty-acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] +synonym: "long-chain fatty acyl CoA metabolic process" EXACT [] +synonym: "long-chain fatty acyl-CoA metabolism" EXACT [] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:0035337 +name: fatty-acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] +synonym: "fatty acyl CoA metabolic process" EXACT [] +synonym: "fatty-acyl-CoA metabolism" EXACT [] +is_a: GO:0006637 ! acyl-CoA metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:0035338 +name: long-chain fatty-acyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [ISBN:0198506732] +synonym: "long-chain fatty acyl CoA biosynthetic process" EXACT [] +synonym: "long-chain fatty-acyl-CoA anabolism" EXACT [] +synonym: "long-chain fatty-acyl-CoA biosynthesis" EXACT [] +synonym: "long-chain fatty-acyl-CoA formation" EXACT [] +synonym: "long-chain fatty-acyl-CoA synthesis" EXACT [] +is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process + +[Term] +id: GO:0035339 +name: SPOTS complex +namespace: cellular_component +def: "A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis." [PMID:20182505] +synonym: "serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex" NARROW [] +is_a: GO:0017059 ! serine C-palmitoyltransferase complex + +[Term] +id: GO:0035340 +name: inosine transport +namespace: biological_process +def: "The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:19135251] +synonym: "hypoxanthine riboside transport" EXACT [] +is_a: GO:0015858 ! nucleoside transport + +[Term] +id: GO:0035341 +name: regulation of inosine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "regulation of hypoxanthine riboside transport" EXACT [] +is_a: GO:0032245 ! regulation of purine nucleoside transport +relationship: regulates GO:0035340 ! inosine transport + +[Term] +id: GO:0035342 +name: positive regulation of inosine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "positive regulation of hypoxanthine riboside transport" EXACT [] +is_a: GO:0032248 ! positive regulation of purine nucleoside transport +is_a: GO:0035341 ! regulation of inosine transport +relationship: positively_regulates GO:0035340 ! inosine transport + +[Term] +id: GO:0035343 +name: negative regulation of inosine transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "negative regulation of hypoxanthine riboside transport" EXACT [] +is_a: GO:0032247 ! negative regulation of purine nucleoside transport +is_a: GO:0035341 ! regulation of inosine transport +relationship: negatively_regulates GO:0035340 ! inosine transport + +[Term] +id: GO:0035344 +name: hypoxanthine transport +namespace: biological_process +def: "The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sl] +synonym: "6-hydroxypurine transport" EXACT [] +synonym: "hypoxanthine transmembrane transport" EXACT [GOC:mah] +is_a: GO:0006863 ! purine nucleobase transport + +[Term] +id: GO:0035345 +name: regulation of hypoxanthine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "regulation of 6-hydroxypurine transport" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +relationship: regulates GO:0035344 ! hypoxanthine transport + +[Term] +id: GO:0035346 +name: positive regulation of hypoxanthine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "positive regulation of 6-hydroxypurine transport" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport +is_a: GO:0035345 ! regulation of hypoxanthine transport +relationship: positively_regulates GO:0035344 ! hypoxanthine transport + +[Term] +id: GO:0035347 +name: negative regulation of hypoxanthine transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf] +synonym: "negative regulation of 6-hydroxypurine transport" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0035345 ! regulation of hypoxanthine transport +relationship: negatively_regulates GO:0035344 ! hypoxanthine transport + +[Term] +id: GO:0035348 +name: acetyl-CoA transmembrane transport +namespace: biological_process +def: "The process in which acetyl-CoA is transported across a membrane. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GO:bf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "acetyl-CoA membrane transport" EXACT [] +is_a: GO:0015876 ! acetyl-CoA transport +is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0035349 +name: coenzyme A transmembrane transport +namespace: biological_process +def: "The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:bf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "coenzyme A membrane transport" EXACT [] +is_a: GO:0015880 ! coenzyme A transport +is_a: GO:0071106 ! adenosine 3',5'-bisphosphate transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0035350 +name: FAD transmembrane transport +namespace: biological_process +def: "The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [GOC:bf, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "FAD membrane transport" EXACT [] +is_a: GO:0015883 ! FAD transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:0035351 +name: heme transmembrane transport +namespace: biological_process +def: "The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:bf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "heme membrane transport" EXACT [] +is_a: GO:0015886 ! heme transport +is_a: GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0035352 +name: NAD transmembrane transport +namespace: biological_process +def: "The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:bf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "NAD membrane transport" EXACT [] +is_a: GO:0043132 ! NAD transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:0035353 +name: nicotinamide mononucleotide transmembrane transport +namespace: biological_process +def: "The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [GOC:bf, ISBN:0721662544] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "nicotinamide mononucleotide membrane transport" EXACT [] +is_a: GO:0015890 ! nicotinamide mononucleotide transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:0035354 +name: Toll-like receptor 1-Toll-like receptor 2 protein complex +namespace: cellular_component +alt_id: GO:0038125 +def: "A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2)." [GOC:add, GOC:signaling, PMID:17889651, PMID:21481769] +synonym: "TLR1-TLR2 protein complex" EXACT [] +synonym: "TLR1:TLR2 complex" EXACT [] +synonym: "TLR2:TLR1 heterodimer" EXACT [GOC:bf] +synonym: "toll-like receptor TLR1:TLR2 heterodimeric complex" EXACT [GOC:bf] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0035355 +name: Toll-like receptor 2-Toll-like receptor 6 protein complex +namespace: cellular_component +alt_id: GO:0038126 +def: "A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6)." [GOC:add, GOC:signaling, PMID:19931471, PMID:21481769] +synonym: "TLR2-TLR6 protein complex" EXACT [] +synonym: "TLR2:TLR6 heterodimer" EXACT [GOC:bf] +synonym: "TLR6:TLR2 complex" EXACT [] +synonym: "toll-like receptor TLR6:TLR2 heterodimeric complex" EXACT [GOC:bf] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0035356 +name: cellular triglyceride homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment." [GOC:BHF] +is_a: GO:0055082 ! cellular chemical homeostasis +is_a: GO:0070328 ! triglyceride homeostasis + +[Term] +id: GO:0035357 +name: peroxisome proliferator activated receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes." [GOC:BHF, PMID:18221086] +synonym: "peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] +synonym: "peroxisome proliferator-activated receptor signaling pathway" EXACT [] +synonym: "PPAR signaling pathway" EXACT [] +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0035358 +name: regulation of peroxisome proliferator activated receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] +synonym: "regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] +synonym: "regulation of PPAR signaling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway + +[Term] +id: GO:0035359 +name: negative regulation of peroxisome proliferator activated receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] +synonym: "negative regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] +synonym: "negative regulation of PPAR signaling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway +relationship: negatively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway + +[Term] +id: GO:0035360 +name: positive regulation of peroxisome proliferator activated receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." [GOC:bf] +synonym: "positive regulation of peroxisome proliferator activated receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of peroxisome proliferator-activated receptor signaling pathway" EXACT [] +synonym: "positive regulation of PPAR signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0035358 ! regulation of peroxisome proliferator activated receptor signaling pathway +relationship: positively_regulates GO:0035357 ! peroxisome proliferator activated receptor signaling pathway + +[Term] +id: GO:0035361 +name: Cul8-RING ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins." [GOC:krc, PMID:20139071] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0035362 +name: protein-DNA ISRE complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, PMID:11747630] +synonym: "protein-DNA interferon-stimulated response element complex assembly" EXACT [] +is_a: GO:0065004 ! protein-DNA complex assembly + +[Term] +id: GO:0035363 +name: histone locus body +namespace: cellular_component +def: "A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body." [GOC:sart, PMID:16533947, PMID:18927579, PMID:19620235] +synonym: "HLB" EXACT [PMID:16533947, PMID:18927579, PMID:19620235] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0035364 +name: thymine transport +namespace: biological_process +def: "The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO:sl] +synonym: "5-methyluracil transport" EXACT [] +synonym: "thymine transmembrane transport" EXACT [GOC:mah] +is_a: GO:0015855 ! pyrimidine nucleobase transport + +[Term] +id: GO:0035365 +name: regulation of thymine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] +synonym: "regulation of 5-methyluracil transport" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +relationship: regulates GO:0035364 ! thymine transport + +[Term] +id: GO:0035366 +name: negative regulation of thymine transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] +synonym: "negative regulation of 5-methyluracil transport" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0035365 ! regulation of thymine transport +relationship: negatively_regulates GO:0035364 ! thymine transport + +[Term] +id: GO:0035367 +name: positive regulation of thymine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:sl] +synonym: "positive regulation of 5-methyluracil transport" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport +is_a: GO:0035365 ! regulation of thymine transport +relationship: positively_regulates GO:0035364 ! thymine transport + +[Term] +id: GO:0035368 +name: selenocysteine insertion sequence binding +namespace: molecular_function +def: "Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation." [GOC:imk, PMID:10760958] +synonym: "SECIS binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0035369 +name: pre-B cell receptor complex +namespace: cellular_component +def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522] +comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome. +synonym: "pre-BCR" EXACT [] +is_a: GO:0098796 ! membrane protein complex + +[Term] +id: GO:0035370 +name: UBC13-UEV1A complex +namespace: cellular_component +def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A)." [GOC:amm, PMID:16129784] +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex + +[Term] +id: GO:0035371 +name: microtubule plus-end +namespace: cellular_component +def: "The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability." [GOC:bf, GOC:lb, PMID:12700769, PMID:16643273] +synonym: "growing microtubule plus end" EXACT [] +synonym: "microtubule plus end" EXACT [] +is_a: GO:1990752 ! microtubule end + +[Term] +id: GO:0035372 +name: protein localization to microtubule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] +synonym: "protein localisation to microtubule" EXACT [GOC:mah] +is_a: GO:0072698 ! protein localization to microtubule cytoskeleton + +[Term] +id: GO:0035373 +name: chondroitin sulfate proteoglycan binding +namespace: molecular_function +def: "Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit." [GOC:kmv, ISBN:0198506732] +is_a: GO:0005539 ! glycosaminoglycan binding +is_a: GO:0043394 ! proteoglycan binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0035374 +name: chondroitin sulfate binding +namespace: molecular_function +def: "Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc)." [GOC:kmv, ISBN:0198506732] +is_a: GO:0005539 ! glycosaminoglycan binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0035375 +name: zymogen binding +namespace: molecular_function +def: "Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." [ISBN:0198506732] +synonym: "proenzyme binding" NARROW [ISBN:0198506732] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035376 +name: sterol import +namespace: biological_process +def: "The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, PMID:19793923] +synonym: "sterol influx" EXACT [PMID:12077145] +synonym: "sterol uptake" EXACT [PMID:12077145] +is_a: GO:0015918 ! sterol transport + +[Term] +id: GO:0035377 +name: transepithelial water transport +namespace: biological_process +def: "The directed movement of water (H2O) from one side of an epithelium to the other." [GOC:yaf] +is_a: GO:0006833 ! water transport +is_a: GO:0042045 ! epithelial fluid transport + +[Term] +id: GO:0035378 +name: carbon dioxide transmembrane transport +namespace: biological_process +def: "The process in which carbon dioxide (CO2) is transported across a membrane." [GOC:yaf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "carbon dioxide membrane transport" EXACT [] +is_a: GO:0015670 ! carbon dioxide transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0035379 +name: carbon dioxide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other." [GOC:yaf] +xref: Reactome:R-HSA-1237042 "AQP1 passively tranlocates carbon dioxide from the extracellular region to the cytosol" +xref: Reactome:R-HSA-1237069 "RhAG passively translocates carbon dioxide from the extracellular region to the cytosol" +xref: Reactome:R-HSA-1247645 "RhAG passively translocates carbon dioxide from the cytosol to the extracellular region" +xref: Reactome:R-HSA-1247649 "AQP1 passively translocates carbon dioxide from the cytosol to the extracellular region" +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0035380 +name: very long-chain-3-hydroxyacyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pde] +synonym: "very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0035381 +name: ATP-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022834 ! ligand-gated channel activity + +[Term] +id: GO:0035382 +name: sterol transmembrane transport +namespace: biological_process +def: "The process in which a sterol is transported across a membrane. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "sterol membrane transport" EXACT [] +is_a: GO:0015918 ! sterol transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0035383 +name: thioester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, Wikipedia:Thioester] +synonym: "thioester metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0035384 +name: thioester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol." [GOC:bf, http://encyclopedia.thefreedictionary.com/Thioester] +synonym: "thioester anabolism" EXACT [] +synonym: "thioester biosynthesis" EXACT [] +synonym: "thioester formation" EXACT [] +synonym: "thioester synthesis" EXACT [] +is_a: GO:0035383 ! thioester metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0035385 +name: Roundabout signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] +synonym: "ROBO signaling pathway" EXACT [] +synonym: "ROBO/SLIT signaling pathway" EXACT [] +synonym: "Roundabout signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0035386 +name: regulation of Roundabout signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] +synonym: "regulation of Roundabout signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0035385 ! Roundabout signaling pathway + +[Term] +id: GO:0035387 +name: negative regulation of Roundabout signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] +synonym: "negative regulation of Roundabout signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0035386 ! regulation of Roundabout signaling pathway +relationship: negatively_regulates GO:0035385 ! Roundabout signaling pathway + +[Term] +id: GO:0035388 +name: positive regulation of Roundabout signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway." [GOC:BHF] +synonym: "positive regulation of Roundabout signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0035386 ! regulation of Roundabout signaling pathway +relationship: positively_regulates GO:0035385 ! Roundabout signaling pathway + +[Term] +id: GO:0035391 +name: obsolete maintenance of chromatin silencing at silent mating-type cassette +namespace: biological_process +def: "OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci." [GOC:vw] +comment: This term was obsoleted because it represents a phenotype. +is_obsolete: true + +[Term] +id: GO:0035392 +name: obsolete maintenance of chromatin silencing at telomere +namespace: biological_process +def: "OBSOLETE. The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere." [GOC:vw] +comment: This term was obsoleted because it represented a phenotype. +is_obsolete: true + +[Term] +id: GO:0035393 +name: chemokine (C-X-C motif) ligand 9 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] +subset: gocheck_do_not_annotate +synonym: "CXCL9 production" EXACT [] +synonym: "MIG production" EXACT [] +synonym: "Monokine induced by gamma interferon production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0035394 +name: regulation of chemokine (C-X-C motif) ligand 9 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] +synonym: "regulation of CXCL9 production" EXACT [] +synonym: "regulation of MIG production" EXACT [] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production + +[Term] +id: GO:0035395 +name: negative regulation of chemokine (C-X-C motif) ligand 9 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] +synonym: "negative regulation of CXCL9 production" EXACT [] +synonym: "negative regulation of MIG production" EXACT [] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production +relationship: negatively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production + +[Term] +id: GO:0035396 +name: positive regulation of chemokine (C-X-C motif) ligand 9 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9." [GOC:bf] +synonym: "positive regulation of CXCL9 production" EXACT [] +synonym: "positive regulation of MIG production" EXACT [] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0035394 ! regulation of chemokine (C-X-C motif) ligand 9 production +relationship: positively_regulates GO:0035393 ! chemokine (C-X-C motif) ligand 9 production + +[Term] +id: GO:0035397 +name: helper T cell enhancement of adaptive immune response +namespace: biological_process +def: "Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell." [GOC:add] +synonym: "provision of T cell help" EXACT [] +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0035398 +name: helper T cell enhancement of T cell mediated immune response +namespace: biological_process +def: "Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] +synonym: "helper T cell enhancement of T cell mediated immunity" EXACT [] +synonym: "provision of T cell help to T cell" EXACT [] +is_a: GO:0002711 ! positive regulation of T cell mediated immunity +is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response + +[Term] +id: GO:0035399 +name: helper T cell enhancement of B cell mediated immune response +namespace: biological_process +def: "Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell." [GOC:add] +synonym: "helper T cell enhancement of B cell mediated immunity" EXACT [] +synonym: "provision of T cell help to B cell" EXACT [] +is_a: GO:0002714 ! positive regulation of B cell mediated immunity +is_a: GO:0035397 ! helper T cell enhancement of adaptive immune response + +[Term] +id: GO:0035400 +name: histone tyrosine kinase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:bf] +synonym: "histone-tyrosine kinase activity" EXACT [] +is_a: GO:0004715 ! non-membrane spanning protein tyrosine kinase activity +is_a: GO:0035173 ! histone kinase activity + +[Term] +id: GO:0035401 +name: histone kinase activity (H3-Y41 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3." [GOC:bf] +synonym: "histone tyrosine kinase activity (H3-Y41 specific)" EXACT [] +synonym: "histone-tyrosine kinase activity (H3-Y41 specific)" EXACT [] +is_a: GO:0035400 ! histone tyrosine kinase activity + +[Term] +id: GO:0035402 +name: histone kinase activity (H3-T11 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3." [GOC:bf] +synonym: "histone threonine kinase activity (H3-T11 specific)" EXACT [] +synonym: "histone-threonine kinase activity (H3-T11 specific)" EXACT [] +is_a: GO:0035184 ! histone threonine kinase activity + +[Term] +id: GO:0035403 +name: histone kinase activity (H3-T6 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3." [GOC:bf] +synonym: "histone threonine kinase activity (H3-T6 specific)" EXACT [] +synonym: "histone-threonine kinase activity (H3-T6 specific)" EXACT [] +is_a: GO:0035184 ! histone threonine kinase activity + +[Term] +id: GO:0035404 +name: histone-serine phosphorylation +namespace: biological_process +def: "The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf] +synonym: "histone serine phosphorylation" EXACT [] +is_a: GO:0016572 ! histone phosphorylation +is_a: GO:0018105 ! peptidyl-serine phosphorylation + +[Term] +id: GO:0035405 +name: histone-threonine phosphorylation +namespace: biological_process +def: "The modification of histones by addition of a phosphate group to a threonine residue." [GOC:bf] +synonym: "histone threonine phosphorylation" EXACT [] +is_a: GO:0016572 ! histone phosphorylation +is_a: GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:0035406 +name: histone-tyrosine phosphorylation +namespace: biological_process +def: "The modification of histones by addition of a phosphate group to a tyrosine residue." [GOC:bf] +synonym: "histone tyrosine phosphorylation" EXACT [] +is_a: GO:0016572 ! histone phosphorylation +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0035407 +name: histone H3-T11 phosphorylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." [GOC:bf] +is_a: GO:0035405 ! histone-threonine phosphorylation + +[Term] +id: GO:0035408 +name: histone H3-T6 phosphorylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone." [GOC:bf] +is_a: GO:0035405 ! histone-threonine phosphorylation + +[Term] +id: GO:0035409 +name: histone H3-Y41 phosphorylation +namespace: biological_process +def: "The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone." [GOC:bf] +is_a: GO:0035406 ! histone-tyrosine phosphorylation + +[Term] +id: GO:0035410 +name: dihydrotestosterone 17-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH." [GOC:ecd, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=1.1.1.63, PMID:4152755] +xref: EC:1.1.1.51 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0035415 +name: obsolete regulation of mitotic prometaphase +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "regulation of mitotic prometaphase" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035416 +name: obsolete positive regulation of mitotic prometaphase +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "positive regulation of mitotic prometaphase" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035417 +name: obsolete negative regulation of mitotic prometaphase +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region." [GOC:bf] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "negative regulation of mitotic prometaphase" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035418 +name: protein localization to synapse +namespace: biological_process +def: "Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:bf] +synonym: "protein localisation to synapse" EXACT [GOC:mah] +is_a: GO:1902414 ! protein localization to cell junction + +[Term] +id: GO:0035419 +name: obsolete activation of MAPK activity involved in innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +comment: This term was obsoleted because it should be represented as a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0035420 +name: obsolete MAPK cascade involved in innate immune response +namespace: biological_process +def: "OBSOLETE. A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "MAPKKK cascade involved in innate immune response" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0035421 +name: obsolete activation of MAPKK activity involved in innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0035422 +name: obsolete activation of MAPKKK activity involved in innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +comment: This term was obsoleted because it should be represented as a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0035423 +name: obsolete inactivation of MAPK activity involved in innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0035424 +name: obsolete MAPK import into nucleus involved in innate immune response +namespace: biological_process +def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:bf] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "nuclear translocation of MAPK involved in innate immune response" NARROW [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0035425 +name: autocrine signaling +namespace: biological_process +def: "Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type." [GOC:bf, ISBN:3527303782] +synonym: "autocrine signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0035426 +name: extracellular matrix-cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information between the extracellular matrix and a cell." [GOC:bf] +synonym: "cell-extracellular matrix signalling" EXACT [] +synonym: "extracellular matrix-cell signalling" EXACT [] +is_a: GO:0007154 ! cell communication +is_a: GO:0023052 ! signaling + +[Term] +id: GO:0035429 +name: gluconate transmembrane transport +namespace: biological_process +alt_id: GO:0015725 +def: "The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose." [GOC:vw, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "gluconate membrane transport" EXACT [] +synonym: "gluconate transport" RELATED [] +is_a: GO:0042873 ! aldonate transmembrane transport + +[Term] +id: GO:0035430 +name: regulation of gluconate transmembrane transport +namespace: biological_process +alt_id: GO:0032893 +def: "Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] +synonym: "regulation of gluconate membrane transport" EXACT [] +synonym: "regulation of gluconate transport" RELATED [] +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: regulates GO:0035429 ! gluconate transmembrane transport + +[Term] +id: GO:0035431 +name: negative regulation of gluconate transmembrane transport +namespace: biological_process +alt_id: GO:0032894 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] +synonym: "down regulation of gluconate transport" EXACT [] +synonym: "down-regulation of gluconate transport" EXACT [] +synonym: "downregulation of gluconate transport" EXACT [] +synonym: "inhibition of gluconate transport" NARROW [] +synonym: "negative regulation of gluconate membrane transport" EXACT [] +synonym: "negative regulation of gluconate transport" RELATED [] +is_a: GO:0035430 ! regulation of gluconate transmembrane transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +relationship: negatively_regulates GO:0035429 ! gluconate transmembrane transport + +[Term] +id: GO:0035432 +name: positive regulation of gluconate transmembrane transport +namespace: biological_process +alt_id: GO:0032895 +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore." [GOC:vw] +synonym: "activation of gluconate transport" NARROW [] +synonym: "induction of gluconate transport" NARROW [] +synonym: "positive regulation of gluconate membrane transport" EXACT [] +synonym: "positive regulation of gluconate transport" RELATED [] +synonym: "stimulation of gluconate transport" NARROW [] +synonym: "up regulation of gluconate transport" EXACT [] +synonym: "up-regulation of gluconate transport" EXACT [] +synonym: "upregulation of gluconate transport" EXACT [] +is_a: GO:0035430 ! regulation of gluconate transmembrane transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +relationship: positively_regulates GO:0035429 ! gluconate transmembrane transport + +[Term] +id: GO:0035433 +name: acetate transmembrane transport +namespace: biological_process +def: "The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "acetate membrane transport" EXACT [] +is_a: GO:0006846 ! acetate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0035434 +name: copper ion transmembrane transport +namespace: biological_process +alt_id: GO:1901473 +def: "The directed movement of copper cation across a membrane." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "copper cation transmembrane transport" EXACT [] +synonym: "copper ion membrane transport" EXACT [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0035435 +name: phosphate ion transmembrane transport +namespace: biological_process +def: "The process in which a phosphate is transported across a membrane." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "phosphate ion membrane transport" EXACT [] +is_a: GO:0006817 ! phosphate ion transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:0035436 +name: triose phosphate transmembrane transport +namespace: biological_process +def: "The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester." [GOC:bf, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "triose phosphate membrane transport" EXACT [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015717 ! triose phosphate transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0035437 +name: maintenance of protein localization in endoplasmic reticulum +namespace: biological_process +def: "Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum." [GOC:bf, GOC:vw] +synonym: "maintenance of protein localisation in endoplasmic reticulum" EXACT [GOC:mah] +synonym: "maintenance of protein localization in ER" EXACT [] +synonym: "maintenance of protein location in endoplasmic reticulum" EXACT [] +synonym: "maintenance of protein location in ER" EXACT [] +synonym: "protein-endoplasmic reticulum retention" EXACT [] +synonym: "protein-ER retention" EXACT [] +synonym: "retention of protein in endoplasmic reticulum" EXACT [] +synonym: "retention of protein in ER" EXACT [] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:0035438 +name: cyclic-di-GMP binding +namespace: molecular_function +def: "Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate." [GOC:bf] +synonym: "3',5'-cyclic di-GMP binding" EXACT [] +synonym: "c-di-GMP binding" EXACT [] +synonym: "cyclic dinucleotide di-GMP binding" EXACT [] +is_a: GO:0030551 ! cyclic nucleotide binding +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0035439 +name: halimadienyl-diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate." [EC:5.5.1.16] +synonym: "halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)" RELATED [EC:5.5.1.16] +synonym: "halimadienyl diphosphate synthase activity" RELATED [EC:5.5.1.16] +xref: EC:5.5.1.16 +xref: RHEA:25621 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0035440 +name: tuberculosinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria." [MetaCyc:PWY-5935] +synonym: "halima-5,6,dien-15-ol biosynthesis" EXACT [] +synonym: "halima-5,6,dien-15-ol biosynthetic process" EXACT [] +synonym: "tuberculosinol biosynthesis" EXACT [] +xref: MetaCyc:PWY-5935 +is_a: GO:0016102 ! diterpenoid biosynthetic process + +[Term] +id: GO:0035441 +name: cell migration involved in vasculogenesis +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes." [GOC:dgh] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0001570 ! vasculogenesis + +[Term] +id: GO:0035442 +name: dipeptide transmembrane transport +namespace: biological_process +def: "The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "dipeptide membrane transport" EXACT [] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0042938 ! dipeptide transport + +[Term] +id: GO:0035443 +name: tripeptide transmembrane transport +namespace: biological_process +def: "The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "tripeptide membrane transport" EXACT [] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0042939 ! tripeptide transport + +[Term] +id: GO:0035444 +name: nickel cation transmembrane transport +namespace: biological_process +def: "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "nickel cation membrane transport" EXACT [] +is_a: GO:0015675 ! nickel cation transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0035445 +name: borate transmembrane transport +namespace: biological_process +def: "The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [GOC:curators] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "borate membrane transport" EXACT [] +synonym: "boron transmembrane transport" RELATED [] +is_a: GO:0046713 ! borate transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:0035446 +name: cysteine-glucosaminylinositol ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins." [EC:6.3.1.13, MetaCyc:RXN1G-4, PMID:12033919] +synonym: "desacetylmycothiol synthase" RELATED [PMID:12033919] +synonym: "L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase" RELATED [EC:6.3.1.13] +synonym: "MshC ligase" RELATED [EC:6.3.1.13] +xref: EC:6.3.1.13 +xref: MetaCyc:RXN1G-4 +xref: RHEA:26176 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0035447 +name: mycothiol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol." [MetaCyc:MONOMER-9684, PMID:12033919] +synonym: "acetyl-CoA:Cys-GlcN-Ins acetyltransferase" EXACT [] +xref: MetaCyc:MONOMER-9684 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0035448 +name: extrinsic component of thylakoid membrane +namespace: cellular_component +def: "The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to thylakoid membrane" NARROW [] +synonym: "peripheral to thylakoid membrane" EXACT [] +is_a: GO:0019898 ! extrinsic component of membrane +relationship: part_of GO:0042651 ! thylakoid membrane + +[Term] +id: GO:0035449 +name: extrinsic component of plastid thylakoid membrane +namespace: cellular_component +def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to plastid thylakoid membrane" NARROW [] +synonym: "peripheral to plastid thylakoid membrane" EXACT [] +is_a: GO:0035448 ! extrinsic component of thylakoid membrane +is_a: GO:0035452 ! extrinsic component of plastid membrane +relationship: part_of GO:0055035 ! plastid thylakoid membrane + +[Term] +id: GO:0035450 +name: extrinsic component of lumenal side of plastid thylakoid membrane +namespace: cellular_component +def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to lumenal leaflet of plastid thylakoid membrane" EXACT [GOC:ab] +synonym: "extrinsic to lumenal side of plastid thylakoid membrane" NARROW [] +synonym: "peripheral to lumenal side of plastid thylakoid membrane" EXACT [] +is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane +is_a: GO:0035453 ! extrinsic component of plastid inner membrane +relationship: part_of GO:0098570 ! stromal side of plastid inner membrane + +[Term] +id: GO:0035451 +name: extrinsic component of stromal side of plastid thylakoid membrane +namespace: cellular_component +def: "The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to stromal leaflet of plastid thylakoid membrane" EXACT [GOC:ab] +synonym: "extrinsic to stromal side of plastid thylakoid membrane" NARROW [] +synonym: "peripheral to stromal side of plastid thylakoid membrane" EXACT [] +is_a: GO:0035449 ! extrinsic component of plastid thylakoid membrane +relationship: part_of GO:0098572 ! stromal side of plastid thylakoid membrane + +[Term] +id: GO:0035452 +name: extrinsic component of plastid membrane +namespace: cellular_component +def: "The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to plastid membrane" NARROW [] +synonym: "peripheral to plastid membrane" EXACT [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0042170 ! plastid membrane + +[Term] +id: GO:0035453 +name: extrinsic component of plastid inner membrane +namespace: cellular_component +def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to plastid inner membrane" NARROW [] +synonym: "peripheral to plastid inner membrane" EXACT [] +is_a: GO:0035452 ! extrinsic component of plastid membrane +relationship: part_of GO:0009528 ! plastid inner membrane + +[Term] +id: GO:0035454 +name: extrinsic component of stromal side of plastid inner membrane +namespace: cellular_component +def: "The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region." [GOC:bf, GOC:dos] +synonym: "extrinsic to stromal leaflet of plastid inner membrane" EXACT [GOC:ab] +synonym: "extrinsic to stromal side of plastid inner membrane" NARROW [] +synonym: "peripheral to stromal side of plastid inner membrane" EXACT [] +is_a: GO:0035450 ! extrinsic component of lumenal side of plastid thylakoid membrane + +[Term] +id: GO:0035455 +name: response to interferon-alpha +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl, PMID:11356686] +synonym: "response to interferon alfa-n1" RELATED [GOC:sl] +synonym: "response to interferon alfa-n3" RELATED [GOC:sl] +synonym: "response to leukocyte interferon" EXACT [GOC:sl] +synonym: "response to lymphoblast interferon" EXACT [GOC:sl] +synonym: "response to lymphoblastoid interferon" EXACT [GOC:sl] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0035456 +name: response to interferon-beta +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl, PMID:9561374] +synonym: "response to beta-1 interferon" RELATED [GOC:sl] +synonym: "response to fiblaferon" EXACT [GOC:sl] +synonym: "response to fibroblast interferon" EXACT [GOC:sl] +synonym: "response to interferon beta" EXACT [GOC:hp, PR:000008924] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0035457 +name: cellular response to interferon-alpha +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon." [GOC:sl] +synonym: "cellular response to interferon alfa-n1" RELATED [GOC:sl] +synonym: "cellular response to interferon alfa-n3" RELATED [GOC:sl] +synonym: "cellular response to leukocyte interferon" EXACT [GOC:sl] +synonym: "cellular response to lymphoblast interferon" EXACT [GOC:sl] +synonym: "cellular response to lymphoblastoid interferon" EXACT [GOC:sl] +is_a: GO:0035455 ! response to interferon-alpha +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0035458 +name: cellular response to interferon-beta +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon." [GOC:sl] +synonym: "cellular response to beta-1 interferon" RELATED [GOC:sl] +synonym: "cellular response to fiblaferon" EXACT [GOC:sl] +synonym: "cellular response to fibroblast interferon" EXACT [GOC:sl] +is_a: GO:0035456 ! response to interferon-beta +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0035459 +name: vesicle cargo loading +namespace: biological_process +def: "The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:bf, GOC:lb] +synonym: "cargo loading into vesicle" EXACT [] +synonym: "cargo selection" EXACT [GOC:vw] +is_a: GO:0006810 ! transport +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0035460 +name: L-ascorbate 6-phosphate lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." [PMID:18097099, PMID:20359483] +xref: RHEA:28803 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0035461 +name: vitamin transmembrane transport +namespace: biological_process +def: "The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:bf] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "vitamin membrane transport" EXACT [] +is_a: GO:0051180 ! vitamin transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0035462 +name: determination of left/right asymmetry in diencephalon +namespace: biological_process +def: "The establishment of the diencephalon with respect to the left and right halves." [GOC:dgh, PMID:15084459] +is_a: GO:0035545 ! determination of left/right asymmetry in nervous system +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0035463 +name: transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves." [GOC:dgh, GOC:signaling] +synonym: "TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0035464 +name: regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves." [GOC:dgh] +synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of left/right asymmetry" EXACT [] +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +relationship: regulates GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry + +[Term] +id: GO:0035465 +name: obsolete regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves." [GOC:dgh, PMID:15084459] +comment: This term was made obsolete because it describes regulation of the nodal signaling pathway. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. +synonym: "regulation of TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "regulation of TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "regulation of TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "regulation of TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] +is_obsolete: true +replaced_by: GO:1900175 + +[Term] +id: GO:0035469 +name: determination of pancreatic left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism." [GOC:dgh, PMID:12702646] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0031016 ! pancreas development + +[Term] +id: GO:0035470 +name: positive regulation of vascular wound healing +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:rph] +is_a: GO:0045766 ! positive regulation of angiogenesis +is_a: GO:0061043 ! regulation of vascular wound healing +is_a: GO:0090303 ! positive regulation of wound healing +relationship: positively_regulates GO:0061042 ! vascular wound healing + +[Term] +id: GO:0035471 +name: luteinizing hormone signaling pathway involved in ovarian follicle development +namespace: biological_process +def: "The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:bf] +synonym: "luteinizing hormone signalling pathway involved in ovarian follicle development" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0042700 ! luteinizing hormone signaling pathway +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0035472 +name: choriogonadotropin hormone receptor activity +namespace: molecular_function +def: "Combining with the choriogonadotropin hormone to initiate a change in cell activity." [GOC:bf, ISBN:0198506732, PMID:1922095] +synonym: "CG receptor activity" EXACT [ISBN:0198506732] +synonym: "chorio-gonadotrophin receptor activity" EXACT [ISBN:0198506732] +synonym: "chorionic gonadotropin hormone receptor" EXACT [ISBN:0198506732] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0035473 +name: lipase binding +namespace: molecular_function +def: "Binding to a lipase." [GOC:BHF] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0035474 +name: selective angioblast sprouting +namespace: biological_process +def: "The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel." [GOC:dgh, PMID:19815777] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0035475 +name: angioblast cell migration involved in selective angioblast sprouting +namespace: biological_process +def: "The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations." [GOC:dgh, PMID:19815777] +is_a: GO:0035476 ! angioblast cell migration +relationship: part_of GO:0035474 ! selective angioblast sprouting + +[Term] +id: GO:0035476 +name: angioblast cell migration +namespace: biological_process +def: "The orderly movement of angioblasts, cells involved in blood vessel morphogenesis." [GOC:dgh, PMID:19815777] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0035477 +name: regulation of angioblast cell migration involved in selective angioblast sprouting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting." [GOC:dgh, PMID:19815777] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:1901342 ! regulation of vasculature development +relationship: regulates GO:0035475 ! angioblast cell migration involved in selective angioblast sprouting + +[Term] +id: GO:0035478 +name: chylomicron binding +namespace: molecular_function +def: "Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE." [GOC:BHF, PMID:17403372] +is_a: GO:0071813 ! lipoprotein particle binding + +[Term] +id: GO:0035479 +name: angioblast cell migration from lateral mesoderm to midline +namespace: biological_process +def: "The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature." [GOC:dgh, PMID:11861480] +is_a: GO:0035476 ! angioblast cell migration + +[Term] +id: GO:0035480 +name: regulation of Notch signaling pathway involved in heart induction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] +synonym: "regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] +is_a: GO:0008593 ! regulation of Notch signaling pathway +relationship: regulates GO:0003137 ! Notch signaling pathway involved in heart induction + +[Term] +id: GO:0035481 +name: positive regulation of Notch signaling pathway involved in heart induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:BHF] +synonym: "positive regulation of Notch signalling pathway involved in heart induction" EXACT [GOC:mah] +is_a: GO:0035480 ! regulation of Notch signaling pathway involved in heart induction +is_a: GO:0045747 ! positive regulation of Notch signaling pathway +relationship: positively_regulates GO:0003137 ! Notch signaling pathway involved in heart induction + +[Term] +id: GO:0035482 +name: gastric motility +namespace: biological_process +def: "The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum." [GOC:cy, ISBN:9781416032458, PMID:16139031] +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0035483 +name: gastric emptying +namespace: biological_process +def: "The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:cy, ISBN:9781416032458] +is_a: GO:0035482 ! gastric motility + +[Term] +id: GO:0035484 +name: adenine/adenine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing an A/A mispair." [GOC:bf, GOC:jh] +synonym: "A/A mispair binding" EXACT [GOC:jh] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035485 +name: adenine/guanine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing an A/G mispair." [GOC:bf, GOC:jh] +synonym: "A/G mispair binding" EXACT [GOC:jh] +synonym: "G/A mispair binding" RELATED [GOC:bf] +synonym: "guanine-adenine mispair binding" EXACT [GOC:bf] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035486 +name: cytosine/cytosine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a C/C mispair." [GOC:bf, GOC:jh] +synonym: "C/C mispair binding" EXACT [GOC:jh] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035487 +name: thymine/thymine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a T/T mispair." [GOC:bf, GOC:jh] +synonym: "T/T mispair binding" EXACT [] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035488 +name: cytosine/thymine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a C/T mispair." [GOC:bf, GOC:jh] +synonym: "C/T mispair binding" EXACT [GOC:jh] +synonym: "T/C mispair binding" EXACT [GOC:bf] +synonym: "thymine/cytosine mispair binding" EXACT [GOC:bf] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035489 +name: guanine/guanine mispair binding +namespace: molecular_function +def: "Binding to a double-stranded DNA region containing a G/G mispair." [GOC:bf, GOC:jh] +synonym: "G/G mispair binding" EXACT [GOC:jh] +is_a: GO:0030983 ! mismatched DNA binding + +[Term] +id: GO:0035490 +name: regulation of leukotriene production involved in inflammatory response +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0002540 ! leukotriene production involved in inflammatory response + +[Term] +id: GO:0035491 +name: positive regulation of leukotriene production involved in inflammatory response +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] +is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0002540 ! leukotriene production involved in inflammatory response + +[Term] +id: GO:0035492 +name: negative regulation of leukotriene production involved in inflammatory response +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response." [GOC:bf] +is_a: GO:0035490 ! regulation of leukotriene production involved in inflammatory response +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0002540 ! leukotriene production involved in inflammatory response + +[Term] +id: GO:0035493 +name: SNARE complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:10872468] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0006906 ! vesicle fusion + +[Term] +id: GO:0035494 +name: SNARE complex disassembly +namespace: biological_process +def: "The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb, PMID:11697877] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0035495 +name: regulation of SNARE complex disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +relationship: regulates GO:0035494 ! SNARE complex disassembly + +[Term] +id: GO:0035496 +name: lipopolysaccharide-1,5-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide." [PMID:11304545] +synonym: "LPS-1,5-galactosyltransferase activity" EXACT [PMID:11304545] +synonym: "UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase" EXACT [PMID:11304545] +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0035497 +name: cAMP response element binding +namespace: molecular_function +def: "Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP." [PMID:2875459, PMID:2900470] +synonym: "cAMP-responsive element binding" EXACT [PMID:2875459] +synonym: "CRE binding" EXACT [PMID:2900470] +synonym: "cyclic AMP response element binding" EXACT [PMID:2900470] +synonym: "cyclic-AMP response element binding" EXACT [PMID:2900470] +synonym: "cyclic-AMP-responsive element binding" EXACT [PMID:2875459] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0035498 +name: carnosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine)." [PMID:20097752] +synonym: "carnosine metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0035499 +name: carnosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine)." [EC:6.3.2.11, PMID:20097752] +synonym: "carnosine anabolism" EXACT [] +synonym: "carnosine biosynthesis" EXACT [] +synonym: "carnosine formation" EXACT [] +synonym: "carnosine synthesis" EXACT [] +is_a: GO:0035498 ! carnosine metabolic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0035500 +name: MH2 domain binding +namespace: molecular_function +def: "Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers." [GOC:curators] +synonym: "MAD homology 2 domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0035501 +name: MH1 domain binding +namespace: molecular_function +def: "Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors." [Pfam:PF03165] +synonym: "MAD homology 1 domain binding" EXACT [Pfam:PF03165] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0035502 +name: metanephric part of ureteric bud development +namespace: biological_process +def: "The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0001657 ! ureteric bud development +relationship: part_of GO:0003338 ! metanephros morphogenesis + +[Term] +id: GO:0035503 +name: ureter part of ureteric bud development +namespace: biological_process +def: "The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0001657 ! ureteric bud development +relationship: part_of GO:0072197 ! ureter morphogenesis + +[Term] +id: GO:0035504 +name: regulation of myosin light chain kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0035505 +name: positive regulation of myosin light chain kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0035504 ! regulation of myosin light chain kinase activity +is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0035506 +name: negative regulation of myosin light chain kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0035504 ! regulation of myosin light chain kinase activity +is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0035507 +name: regulation of myosin-light-chain-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0035508 +name: positive regulation of myosin-light-chain-phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity +is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity + +[Term] +id: GO:0035509 +name: negative regulation of myosin-light-chain-phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity." [GOC:bf, GOC:go_curators] +is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity +is_a: GO:0035507 ! regulation of myosin-light-chain-phosphatase activity + +[Term] +id: GO:0035510 +name: DNA dealkylation +namespace: biological_process +def: "The removal of an alkyl group from one or more nucleotides within an DNA molecule." [GOC:bf] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0035511 +name: oxidative DNA demethylation +namespace: biological_process +def: "Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] +is_a: GO:0070989 ! oxidative demethylation +is_a: GO:0080111 ! DNA demethylation + +[Term] +id: GO:0035512 +name: hydrolytic DNA demethylation +namespace: biological_process +def: "The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule." [GOC:bf] +is_a: GO:0080111 ! DNA demethylation + +[Term] +id: GO:0035513 +name: oxidative RNA demethylation +namespace: biological_process +def: "The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] +is_a: GO:0009451 ! RNA modification +is_a: GO:0070989 ! oxidative demethylation + +[Term] +id: GO:0035514 +name: DNA demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule." [GOC:bf] +is_a: GO:0032451 ! demethylase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0035515 +name: oxidative RNA demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [PMID:12594517, PMID:16482161, PMID:18775698] +synonym: "2-oxoglutarate-dependent RNA demethylase" EXACT [PMID:17991826] +xref: Reactome:R-HSA-8857692 "RNA demethylases demethylate N6-methyladenosine RNA" +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032451 ! demethylase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0035516 +name: oxidative DNA demethylase activity +namespace: molecular_function +alt_id: GO:0103051 +alt_id: GO:0103052 +alt_id: GO:0103053 +def: "Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O(2) = a nucleobase within DNA + formaldehyde + succinate + CO(2)." [PMID:12594517, PMID:16482161, PMID:18775698, RHEA:30299] +synonym: "1-ethyladenine demethylase activity" NARROW [] +synonym: "2-oxoglutarate-dependent DNA demethylase" EXACT [PMID:17991826] +synonym: "N1-methyladenine demethylase activity" NARROW [] +synonym: "N3-methylcytosine demethylase activity" NARROW [] +xref: EC:1.14.11.33 +xref: MetaCyc:RXN0-984 +xref: MetaCyc:RXN0-985 +xref: MetaCyc:RXN0-986 +xref: RHEA:30299 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0035514 ! DNA demethylase activity + +[Term] +id: GO:0035517 +name: PR-DUB complex +namespace: cellular_component +def: "A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively." [PMID:20436459] +synonym: "Polycomb repressive deubiquitinase complex" EXACT [PMID:20436459] +is_a: GO:0031519 ! PcG protein complex + +[Term] +id: GO:0035518 +name: histone H2A monoubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of a single ubiquitin group." [PMID:18206970] +is_a: GO:0010390 ! histone monoubiquitination +is_a: GO:0033522 ! histone H2A ubiquitination + +[Term] +id: GO:0035519 +name: protein K29-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation." [PMID:17028573] +synonym: "protein K29-linked polyubiquitination" EXACT [GOC:mah] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0035520 +name: monoubiquitinated protein deubiquitination +namespace: biological_process +def: "The removal of the ubiquitin group from a monoubiquitinated protein." [GOC:bf] +synonym: "monoubiquitinated protein deubiquitinylation" EXACT [] +synonym: "monoubiquitinated protein deubiquitylation" EXACT [] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0035521 +name: monoubiquitinated histone deubiquitination +namespace: biological_process +def: "The removal of the ubiquitin group from a monoubiquitinated histone protein." [GOC:bf, PMID:20436459] +synonym: "monoubiquitinated histone deubiquitinylation" EXACT [] +synonym: "monoubiquitinated histone deubiquitylation" EXACT [] +is_a: GO:0016578 ! histone deubiquitination +is_a: GO:0035520 ! monoubiquitinated protein deubiquitination + +[Term] +id: GO:0035522 +name: monoubiquitinated histone H2A deubiquitination +namespace: biological_process +def: "The removal of the ubiquitin group from a monoubiquitinated histone H2A protein." [GOC:bf, PMID:18226187, PMID:20436459] +synonym: "monoubiquitinated histone H2A deubiquitinylation" EXACT [] +synonym: "monoubiquitinated histone H2A deubiquitylation" EXACT [] +is_a: GO:0035521 ! monoubiquitinated histone deubiquitination + +[Term] +id: GO:0035523 +name: protein K29-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein." [GOC:bf] +synonym: "protein K29-linked deubiquitinylation" EXACT [] +synonym: "protein K29-linked deubiquitylation" EXACT [] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0035524 +name: proline transmembrane transport +namespace: biological_process +def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "proline membrane transport" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport + +[Term] +id: GO:0035525 +name: NF-kappaB p50/p65 complex +namespace: cellular_component +def: "A heterodimer of NF-kappa B p50 and p65 subunits." [GO:add, PMID:20393192, PMID:9299584] +comment: Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications. +synonym: "NF-kappa B1/p65 complex" EXACT [PMID:9299584] +synonym: "NF-kappa B1/RelA complex" EXACT [PMID:9299584] +synonym: "NF-kappa p105/p65 complex" RELATED [PMID:9299584] +synonym: "NF-kappa p105/RelA complex" RELATED [PMID:9299584] +synonym: "NF-kappa p50/RelA complex" EXACT [PMID:9299584] +is_a: GO:0071159 ! NF-kappaB complex + +[Term] +id: GO:0035526 +name: retrograde transport, plasma membrane to Golgi +namespace: biological_process +def: "The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles." [GOC:lb, PMID:17488291] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0035527 +name: 3-hydroxypropionate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH." [RHEA:26438] +synonym: "3-hydroxypropanoate dehydrogenase (NADP+) activity" EXACT [] +synonym: "3-hydroxypropanoate:NADP+ oxidoreductase" RELATED [EC:1.1.1.298] +synonym: "3-hydroxypropionate:NADP+ oxidoreductase" RELATED [EC:1.1.1.298] +xref: EC:1.1.1.298 +xref: KEGG_REACTION:R09289 +xref: MetaCyc:RXN-8974 +xref: RHEA:26438 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0035528 +name: obsolete UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin." [GOC:bf] +comment: This term was obsoleted because it does not represent a specific pathway. +synonym: "UDP-GlcNAc biosynthesis involved in chitin biosynthesis" EXACT [] +synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthesis" EXACT [] +synonym: "UDP-GlcNAc biosynthetic process involved in chitin biosynthetic process" EXACT [] +synonym: "UDP-N-acetylglucosamine anabolism involved in chitin biosynthesis" EXACT [] +synonym: "UDP-N-acetylglucosamine biosynthetic process involved in chitin biosynthetic process" EXACT [] +synonym: "UDP-N-acetylglucosamine formation involved in chitin biosynthesis" EXACT [] +synonym: "UDP-N-acetylglucosamine synthesis involved in chitin biosynthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035529 +name: NADH pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+." [MetaCyc:RXN0-4401, PMID:12399474, PMID:20181750] +synonym: "NADH diphosphatase activity" EXACT [] +synonym: "NADH pyrophosphohydrolase activity" EXACT [] +xref: EC:3.6.1.9 +xref: KEGG_REACTION:R00103 +xref: MetaCyc:RXN0-4401 +xref: Reactome:R-HSA-6809287 "NUDT12 hydrolyses NADH to NMNH" +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0035530 +name: chemokine (C-C motif) ligand 6 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, PMID:19812544] +subset: gocheck_do_not_annotate +synonym: "CCL6 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0035531 +name: regulation of chemokine (C-C motif) ligand 6 production +namespace: biological_process +alt_id: GO:0035534 +alt_id: GO:0035535 +def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] +synonym: "chemokine (C-C motif) ligand 6 secretion" NARROW [] +synonym: "regulation of CCL6 production" EXACT [] +synonym: "regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production + +[Term] +id: GO:0035532 +name: negative regulation of chemokine (C-C motif) ligand 6 production +namespace: biological_process +alt_id: GO:0035536 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] +synonym: "negative regulation of CCL6 production" EXACT [] +synonym: "negative regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production +relationship: negatively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production + +[Term] +id: GO:0035533 +name: positive regulation of chemokine (C-C motif) ligand 6 production +namespace: biological_process +alt_id: GO:0035537 +def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6)." [GOC:add, GOC:bf] +synonym: "positive regulation of CCL6 production" EXACT [] +synonym: "positive regulation of chemokine (C-C motif) ligand 6 secretion" NARROW [] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0035531 ! regulation of chemokine (C-C motif) ligand 6 production +relationship: positively_regulates GO:0035530 ! chemokine (C-C motif) ligand 6 production + +[Term] +id: GO:0035538 +name: carbohydrate response element binding +namespace: molecular_function +def: "Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes." [GOC:BHF, PMID:20001964] +synonym: "ChoRE binding" EXACT [PMID:20001964] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0035539 +name: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA." [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575] +synonym: "8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity" EXACT [PMID:17804481] +synonym: "8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity" EXACT [PMID:17804481] +synonym: "8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity" EXACT [PMID:7782328] +synonym: "8-oxo-dGTP pyrophosphohydrolase activity" EXACT [PMID:17804481] +synonym: "8-oxo-dGTPase activity" EXACT [PMID:7782328] +xref: EC:3.6.1.55 +xref: Reactome:R-HSA-2395849 "NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP" +xref: Reactome:R-HSA-2395869 "NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP" +xref: RHEA:31575 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0035540 +name: positive regulation of SNARE complex disassembly +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0035495 ! regulation of SNARE complex disassembly +is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0035494 ! SNARE complex disassembly + +[Term] +id: GO:0035541 +name: negative regulation of SNARE complex disassembly +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0035495 ! regulation of SNARE complex disassembly +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0035494 ! SNARE complex disassembly + +[Term] +id: GO:0035542 +name: regulation of SNARE complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0035493 ! SNARE complex assembly + +[Term] +id: GO:0035543 +name: positive regulation of SNARE complex assembly +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0035542 ! regulation of SNARE complex assembly +relationship: positively_regulates GO:0035493 ! SNARE complex assembly + +[Term] +id: GO:0035544 +name: negative regulation of SNARE complex assembly +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." [GOC:rb] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0035542 ! regulation of SNARE complex assembly +relationship: negatively_regulates GO:0035493 ! SNARE complex assembly + +[Term] +id: GO:0035545 +name: determination of left/right asymmetry in nervous system +namespace: biological_process +def: "The establishment of the nervous system with respect to the left and right halves." [GOC:kmv, PMID:17717195, PMID:19641012] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0035550 +name: urease complex +namespace: cellular_component +def: "A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide)." [InterPro:IPR008221, PMID:2651866] +comment: Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes. +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0035551 +name: protein initiator methionine removal involved in protein maturation +namespace: biological_process +def: "Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein." [GOC:bf, GOC:hjd, GOC:vw] +is_a: GO:0016485 ! protein processing +is_a: GO:0070084 ! protein initiator methionine removal +relationship: part_of GO:0051604 ! protein maturation + +[Term] +id: GO:0035552 +name: oxidative single-stranded DNA demethylation +namespace: biological_process +def: "Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698] +synonym: "oxidative ssDNA demethylation" EXACT [] +is_a: GO:0035511 ! oxidative DNA demethylation + +[Term] +id: GO:0035553 +name: oxidative single-stranded RNA demethylation +namespace: biological_process +def: "Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." [GOC:BHF, GOC:rl, PMID:18775698] +synonym: "oxidative ssRNA demethylation" EXACT [] +is_a: GO:0035513 ! oxidative RNA demethylation + +[Term] +id: GO:0035554 +name: termination of Roundabout signal transduction +namespace: biological_process +def: "The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated." [GOC:BHF, GOC:vk] +is_a: GO:0023021 ! termination of signal transduction +is_a: GO:0035387 ! negative regulation of Roundabout signaling pathway +relationship: part_of GO:0035385 ! Roundabout signaling pathway + +[Term] +id: GO:0035555 +name: obsolete initiation of Roundabout signal transduction +namespace: biological_process +def: "OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO)." [GOC:vk] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "initiation of Roundabout signal transduction" EXACT [] +is_obsolete: true +consider: GO:0035385 +consider: GO:0038023 +consider: GO:0048495 + +[Term] +id: GO:0035556 +name: intracellular signal transduction +namespace: biological_process +alt_id: GO:0007242 +alt_id: GO:0007243 +alt_id: GO:0023013 +alt_id: GO:0023034 +def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] +subset: goslim_drosophila +synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling] +synonym: "intracellular signal transduction pathway" NARROW [] +synonym: "intracellular signaling cascade" RELATED [GOC:signaling] +synonym: "intracellular signaling chain" EXACT [ISBN:3527303782] +synonym: "intracellular signaling pathway" RELATED [] +synonym: "protein kinase cascade" NARROW [GOC:signaling] +synonym: "signal transduction via intracellular signaling cascade" RELATED [] +synonym: "signal transmission via intracellular cascade" NARROW [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0035557 +name: obsolete intracellular signal transduction involved in cell surface receptor linked signaling +namespace: biological_process +def: "OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling, ISBN:3527303782] +comment: This term was made obsolete because the syntax of the term is incorrect. +synonym: "intracellular signal transduction involved in cell surface receptor linked signaling" EXACT [] +synonym: "intracellular signal transduction involved in cell surface receptor linked signalling" EXACT [GOC:mah] +synonym: "intracellular signaling cascade involved in cell surface receptor linked signaling" EXACT [] +synonym: "intracellular signaling chain involved in cell surface receptor signaling" EXACT [ISBN:3527303782] +is_obsolete: true + +[Term] +id: GO:0035558 +name: obsolete phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling +namespace: biological_process +def: "OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:signaling] +comment: This term was made obsolete because the syntax of the term is incorrect. +synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling" EXACT [] +synonym: "phosphatidylinositol 3-kinase cascade involved in insulin receptor signalling" EXACT [] +synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signaling" EXACT [] +synonym: "phosphoinositide 3-kinase cascade involved in insulin receptor signalling" EXACT [GOC:mah] +synonym: "PI3K cascade involved in signaling from the insulin receptor" EXACT [] +is_obsolete: true +consider: GO:0038028 + +[Term] +id: GO:0035559 +name: obsolete MAPKKK cascade involved in epidermal growth factor receptor signaling +namespace: biological_process +def: "OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:signaling] +comment: This term was made obsolete because the syntax of the term is incorrect. +synonym: "MAPKKK cascade involved in epidermal growth factor receptor signaling" EXACT [] +synonym: "MAPKKK cascade involved in epidermal growth factor receptor signalling" EXACT [GOC:mah] +synonym: "MAPKKK cascade involved in signaling from the EGFR" EXACT [] +is_obsolete: true +consider: GO:0038029 + +[Term] +id: GO:0035560 +name: pheophorbidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a." [PMID:16228561, RHEA:32483] +synonym: "phedase activity" RELATED [EC:3.1.1.82] +synonym: "pheophoridase activity" RELATED [] +synonym: "PPD activity" RELATED [EC:3.1.1.82] +xref: EC:3.1.1.82 +xref: RHEA:32483 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0035561 +name: regulation of chromatin binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0035562 +name: negative regulation of chromatin binding +namespace: biological_process +def: "Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] +is_a: GO:0035561 ! regulation of chromatin binding +is_a: GO:0051100 ! negative regulation of binding + +[Term] +id: GO:0035563 +name: positive regulation of chromatin binding +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:bf, PMID:20404130] +is_a: GO:0035561 ! regulation of chromatin binding +is_a: GO:0051099 ! positive regulation of binding + +[Term] +id: GO:0035564 +name: regulation of kidney size +namespace: biological_process +def: "Any process that modulates the size of a kidney." [GOC:bf] +is_a: GO:0090066 ! regulation of anatomical structure size +relationship: part_of GO:0060993 ! kidney morphogenesis + +[Term] +id: GO:0035565 +name: regulation of pronephros size +namespace: biological_process +def: "Any process that modulates the size of a pronephric kidney." [GOC:bf] +synonym: "regulation of pronephric kidney size" EXACT [GOC:bf] +is_a: GO:0035564 ! regulation of kidney size +relationship: part_of GO:0072114 ! pronephros morphogenesis + +[Term] +id: GO:0035566 +name: regulation of metanephros size +namespace: biological_process +def: "Any process that modulates the size of a metanephric kidney." [GOC:bf] +synonym: "regulation of metanephric kidney size" EXACT [GOC:bf] +is_a: GO:0035564 ! regulation of kidney size +relationship: part_of GO:0003338 ! metanephros morphogenesis + +[Term] +id: GO:0035567 +name: non-canonical Wnt signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin." [GOC:signaling] +comment: This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term. +synonym: "beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:signaling] +synonym: "non-canonical Wnt receptor signaling pathway" EXACT [] +synonym: "non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway + +[Term] +id: GO:0035568 +name: N-terminal peptidyl-proline methylation +namespace: biological_process +def: "The methylation of the N-terminal proline of proteins." [PMID:20668449, RESID:AA0419] +xref: RESID:AA0419 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0035569 +name: obsolete N-terminal peptidyl-proline trimethylation +namespace: biological_process +def: "OBSOLETE. The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline." [PMID:20668449] +comment: This term was made obsolete because N-terminal proline residues cannot be trimethylated. +synonym: "N-terminal peptidyl-proline trimethylation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035570 +name: N-terminal peptidyl-serine methylation +namespace: biological_process +def: "The methylation of the N-terminal serine of proteins." [PMID:20668449] +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0035571 +name: N-terminal peptidyl-serine monomethylation +namespace: biological_process +def: "The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." [PMID:20668449] +is_a: GO:0035570 ! N-terminal peptidyl-serine methylation + +[Term] +id: GO:0035572 +name: N-terminal peptidyl-serine dimethylation +namespace: biological_process +def: "The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine." [PMID:20668449] +is_a: GO:0035570 ! N-terminal peptidyl-serine methylation + +[Term] +id: GO:0035573 +name: N-terminal peptidyl-serine trimethylation +namespace: biological_process +def: "The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine." [PMID:20668449] +is_a: GO:0035570 ! N-terminal peptidyl-serine methylation + +[Term] +id: GO:0035574 +name: histone H4-K20 demethylation +namespace: biological_process +def: "The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone." [GOC:sp, PMID:20622853] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0035575 +name: histone H4-methyl-lysine-20 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20622853, PMID:26214369, PMID:32209475] +synonym: "histone demethylase activity (H4-K20 specific)" EXACT [] +synonym: "histone H4K20me demethylase activity" EXACT [] +xref: Reactome:R-HSA-2172678 "PHF8 demethylates histone H4K20me1" +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0035576 +name: retinoic acid receptor signaling pathway involved in pronephric field specification +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop." [GOC:bf, PMID:16979153, PMID:19909807] +synonym: "retinoic acid receptor signalling pathway involved in pronephric field specification" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0039003 ! pronephric field specification + +[Term] +id: GO:0035577 +name: azurophil granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] +synonym: "primary granule membrane" EXACT [] +is_a: GO:0005765 ! lysosomal membrane +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042582 ! azurophil granule + +[Term] +id: GO:0035578 +name: azurophil granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:bf, PMID:17152095] +synonym: "primary granule lumen" EXACT [] +is_a: GO:0005775 ! vacuolar lumen +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0042582 ! azurophil granule + +[Term] +id: GO:0035579 +name: specific granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] +synonym: "secondary granule membrane" EXACT [] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042581 ! specific granule + +[Term] +id: GO:0035580 +name: specific granule lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:bf, PMID:7334549] +synonym: "secondary granule lumen" EXACT [] +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0042581 ! specific granule + +[Term] +id: GO:0035581 +name: sequestering of extracellular ligand from receptor +namespace: biological_process +def: "The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor." [GOC:BHF, GOC:signaling] +comment: Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex. +synonym: "extracellular sequestering of receptor ligand" EXACT [GOC:bf] +synonym: "negative regulation of protein bioavailability" RELATED [GOC:BHF] +is_a: GO:1900116 ! extracellular negative regulation of signal transduction + +[Term] +id: GO:0035582 +name: sequestering of BMP in extracellular matrix +namespace: biological_process +def: "Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins." [GOC:BHF, PMID:20855508] +comment: Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex. +synonym: "BMP sequestration in the ECM" EXACT [PMID:20855508] +synonym: "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT [GOC:bf] +synonym: "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT [GOC:mah] +synonym: "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT [] +is_a: GO:0030514 ! negative regulation of BMP signaling pathway +is_a: GO:0035581 ! sequestering of extracellular ligand from receptor +is_a: GO:0071694 ! maintenance of protein location in extracellular region + +[Term] +id: GO:0035583 +name: sequestering of TGFbeta in extracellular matrix +namespace: biological_process +def: "Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins." [GOC:bf, GOC:BHF, GOC:signaling, PMID:12482908, PMID:20855508] +synonym: "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:bf] +synonym: "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" EXACT [GOC:mah] +synonym: "sequestering of TGFbeta large latency complex in extracellular matrix" EXACT [PMID:12482908] +synonym: "sequestering of TGFbeta LLC in extracellular matrix" EXACT [PMID:12482908] +is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway +is_a: GO:0035581 ! sequestering of extracellular ligand from receptor +is_a: GO:0071694 ! maintenance of protein location in extracellular region + +[Term] +id: GO:0035584 +name: calcium-mediated signaling using intracellular calcium source +namespace: biological_process +def: "A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] +synonym: "calcium signaling using intracellular calcium source" EXACT [] +synonym: "calcium signalling using intracellular calcium source" EXACT [] +synonym: "calcium-mediated signalling using intracellular calcium source" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0035585 +name: calcium-mediated signaling using extracellular calcium source +namespace: biological_process +def: "A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] +synonym: "calcium signaling using extracellular calcium source" EXACT [] +synonym: "calcium signalling using extracellular calcium source" EXACT [] +synonym: "calcium-mediated signalling using extracellular calcium source" EXACT [] +synonym: "extracellular calcium influx" NARROW [GOC:BHF] +is_a: GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0035588 +name: G protein-coupled purinergic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] +synonym: "G-protein coupled purinergic receptor signaling pathway" EXACT [] +synonym: "G-protein coupled purinergic receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway + +[Term] +id: GO:0035589 +name: G protein-coupled purinergic nucleotide receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:BHF, PMID:9755289] +synonym: "G-protein coupled purinergic nucleotide receptor signaling pathway" EXACT [] +synonym: "G-protein coupled purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] +synonym: "P2Y receptor signaling pathway" EXACT [PMID:9755289] +is_a: GO:0035590 ! purinergic nucleotide receptor signaling pathway + +[Term] +id: GO:0035590 +name: purinergic nucleotide receptor signaling pathway +namespace: biological_process +alt_id: GO:0035587 +def: "The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity." [GOC:BHF, PMID:9755289] +synonym: "P2 receptor signaling pathway" RELATED [PMID:9755289] +synonym: "purinergic nucleotide receptor signalling pathway" EXACT [GOC:mah] +synonym: "purinergic receptor signaling pathway" RELATED [] +synonym: "purinergic receptor signalling pathway" RELATED [GOC:mah] +synonym: "purinoceptor signaling pathway" RELATED [PMID:9755289] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0035591 +name: signaling adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity." [GOC:bf, PMID:19104498] +comment: A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498). +synonym: "signaling scaffold activity" RELATED [] +synonym: "signalling adaptor activity" EXACT [GOC:mah] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0035592 +name: establishment of protein localization to extracellular region +namespace: biological_process +def: "The directed movement of a protein to a specific location within the extracellular region." [GOC:bf, GOC:BHF] +synonym: "establishment of protein localisation in extracellular region" EXACT [GOC:mah] +synonym: "establishment of protein localization in extracellular region" EXACT [] +is_a: GO:0045184 ! establishment of protein localization +is_a: GO:0071692 ! protein localization to extracellular region + +[Term] +id: GO:0035593 +name: positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region." [GOC:BHF, PMID:19906850] +synonym: "positive regulation of Wnt diffusion" NARROW [PMID:19906850] +synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region" EXACT [GOC:mah] +synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region" EXACT [] +synonym: "positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region" EXACT [GOC:mah] +synonym: "positive regulation of Wnt signaling range" RELATED [PMID:19906850] +synonym: "positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region" EXACT [GOC:signaling] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:0035592 ! establishment of protein localization to extracellular region + +[Term] +id: GO:0035594 +name: ganglioside binding +namespace: molecular_function +def: "Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues." [GOC:yaf] +is_a: GO:0043208 ! glycosphingolipid binding +is_a: GO:0097001 ! ceramide binding + +[Term] +id: GO:0035595 +name: N-acetylglucosaminylinositol deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol." [EC:3.5.1.103, GOC:rs] +synonym: "1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity" RELATED [EC:3.5.1.103] +synonym: "1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity" RELATED [EC:3.5.1.103] +synonym: "GlcNAc-Ins deacetylase activity" EXACT [GOC:rs] +synonym: "N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity" RELATED [EC:3.5.1.103] +xref: EC:3.5.1.103 +xref: KEGG_REACTION:R09651 +xref: MetaCyc:RXN1G-2 +xref: RHEA:26180 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0035596 +name: methylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor." [GOC:jh2, PMID:20472640] +synonym: "MTTase" EXACT [PMID:20472640] +is_a: GO:0050497 ! alkylthioltransferase activity + +[Term] +id: GO:0035597 +name: N6-isopentenyladenosine methylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A)." [PMID:20472640] +synonym: "i6A methylthiotransferase activity" EXACT [PMID:20472640] +is_a: GO:0035596 ! methylthiotransferase activity + +[Term] +id: GO:0035598 +name: N6-threonylcarbomyladenosine methylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A)." [PMID:20472640, PMID:20584901] +synonym: "t6A methylthiotransferase activity" EXACT [PMID:20472640] +xref: Reactome:R-HSA-6786571 "CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37" +is_a: GO:0035596 ! methylthiotransferase activity + +[Term] +id: GO:0035599 +name: aspartic acid methylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid." [PMID:18252828, PMID:8844851, RESID:AA0232] +comment: Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12. +xref: RESID:AA0232 +is_a: GO:0035596 ! methylthiotransferase activity + +[Term] +id: GO:0035600 +name: tRNA methylthiolation +namespace: biological_process +def: "The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule." [PMID:20472640] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0035601 +name: protein deacylation +namespace: biological_process +def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] +synonym: "protein amino acid deacylation" EXACT [GOC:se] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0098732 ! macromolecule deacylation + +[Term] +id: GO:0035602 +name: fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mtg_apoptosis, GOC:yaf] +synonym: "FGF receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] +synonym: "FGFR signaling pathway involved in negative regulation of apoptosis in bone marrow" EXACT [GOC:bf] +synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow" NARROW [] +synonym: "fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [] +synonym: "fibroblast growth factor receptor signalling pathway involved in negative regulation of apoptotic process in bone marrow" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0071866 ! negative regulation of apoptotic process in bone marrow cell + +[Term] +id: GO:0035603 +name: fibroblast growth factor receptor signaling pathway involved in hemopoiesis +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis." [GOC:yaf] +synonym: "FGF receptor signaling pathway involved in hematopoiesis" EXACT [GOC:bf] +synonym: "FGFR signaling pathway involved in hematopoiesis" EXACT [GOC:bf] +synonym: "fibroblast growth factor receptor signaling pathway involved in hematopoiesis" EXACT [GOC:yaf] +synonym: "fibroblast growth factor receptor signalling pathway involved in hemopoiesis" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0035604 +name: fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:yaf] +synonym: "FGF receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] +synonym: "FGFR signaling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:bf] +synonym: "fibroblast growth factor receptor signalling pathway involved in positive regulation of cell proliferation in bone marrow" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0071864 ! positive regulation of cell proliferation in bone marrow + +[Term] +id: GO:0035605 +name: peptidyl-cysteine S-nitrosylase activity +namespace: molecular_function +def: "Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein." [EC:2.6.99.-, GOC:sp, PMID:20972425, PMID:20972426] +comment: This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate. +synonym: "protein nitrosylase activity" RELATED [GOC:sp] +synonym: "S-nitrosylase activity" EXACT [PMID:20972426] +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0035606 +name: peptidyl-cysteine S-trans-nitrosylation +namespace: biological_process +def: "Transfer of a nitric oxide (NO) group from one cysteine residue to another." [PMID:19854201, PMID:20972425, PMID:20972426] +synonym: "cysteine to cysteine nitrosylation" EXACT [PMID:20972426] +synonym: "cysteine-to-cysteine transnitrosylation" EXACT [PMID:20972426] +synonym: "protein-to-protein transnitrosylation" BROAD [PMID:20972426] +synonym: "S-transnitrosylation" EXACT [PMID:20972426] +is_a: GO:0018119 ! peptidyl-cysteine S-nitrosylation + +[Term] +id: GO:0035607 +name: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state." [GOC:yaf] +synonym: "FGF receptor signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] +synonym: "FGFR signaling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] +synonym: "fibroblast growth factor receptor signalling pathway involved in orbitofrontal cortex development" EXACT [GOC:bf] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021769 ! orbitofrontal cortex development + +[Term] +id: GO:0035608 +name: protein deglutamylation +namespace: biological_process +def: "The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." [GOC:sp, PMID:21074048] +synonym: "protein amino acid deglutamylation" EXACT [GOC:bf] +is_a: GO:0018200 ! peptidyl-glutamic acid modification + +[Term] +id: GO:0035609 +name: C-terminal protein deglutamylation +namespace: biological_process +def: "The removal of a C-terminal, gene-encoded glutamate residue from a protein." [GOC:sp, PMID:21074048] +synonym: "protein primary sequence deglutamylation" EXACT [PMID:21074048] +is_a: GO:0018410 ! C-terminal protein amino acid modification +is_a: GO:0035608 ! protein deglutamylation + +[Term] +id: GO:0035610 +name: protein side chain deglutamylation +namespace: biological_process +def: "The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation." [GOC:sp, PMID:21074048] +synonym: "removal of posttranslational polyglutamylation" EXACT [PMID:21074048] +synonym: "shortening of glutamate side chain" RELATED [PMID:21074048] +is_a: GO:0035608 ! protein deglutamylation + +[Term] +id: GO:0035611 +name: protein branching point deglutamylation +namespace: biological_process +def: "The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue." [GOC:sp, PMID:21074048] +is_a: GO:0035608 ! protein deglutamylation + +[Term] +id: GO:0035612 +name: AP-2 adaptor complex binding +namespace: molecular_function +def: "Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499] +synonym: "AP-2 clathrin adaptor complex binding" RELATED [GOC:bf] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0035613 +name: RNA stem-loop binding +namespace: molecular_function +def: "Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] +synonym: "RNA hairpin binding" EXACT [PMID:16568238] +synonym: "RNA hairpin loop binding" EXACT [PMID:16568238] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0035614 +name: snRNA stem-loop binding +namespace: molecular_function +def: "Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop." [GOC:sart, PMID:16568238, PMID:20455544] +synonym: "small nuclear RNA stem-loop binding" EXACT [] +synonym: "snRNA hairpin binding" EXACT [PMID:16568238] +synonym: "snRNA hairpin loop binding" EXACT [PMID:16568238] +is_a: GO:0017069 ! snRNA binding +is_a: GO:0035613 ! RNA stem-loop binding + +[Term] +id: GO:0035615 +name: clathrin adaptor activity +namespace: molecular_function +def: "Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles." [GOC:BHF, PMID:15728179] +synonym: "clathrin-associated adaptor activity" EXACT [PMID:15728179] +is_a: GO:0030276 ! clathrin binding +is_a: GO:0140312 ! cargo adaptor activity + +[Term] +id: GO:0035616 +name: histone H2B conserved C-terminal lysine deubiquitination +namespace: biological_process +def: "A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:bf, GOC:vw, PMID:15657442] +synonym: "budding yeast H2B K123 deubiquitination" NARROW [GOC:vw] +synonym: "fission yeast H2B K119 deubiquitination" NARROW [GOC:vw] +synonym: "mammalian H2B K120 deubiquitination" NARROW [GOC:vw] +is_a: GO:0016578 ! histone deubiquitination + +[Term] +id: GO:0035617 +name: stress granule disassembly +namespace: biological_process +def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938] +synonym: "SG disassembly" EXACT [PMID:19825938] +is_a: GO:0032988 ! ribonucleoprotein complex disassembly +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0035618 +name: root hair +namespace: cellular_component +def: "A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall." [http://www.jstor.org/stable/4354264, PO:0000256] +comment: This term is a child of 'cell projection' and not 'cell hair' to distinguish it from animal cell hairs, which are morphologically distinct. +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0035619 +name: root hair tip +namespace: cellular_component +def: "The tip portion of an outgrowth of a root epidermal cell." [PMID:16567499] +synonym: "root hair cell tip" EXACT [] +is_a: GO:0051286 ! cell tip +relationship: part_of GO:0035618 ! root hair + +[Term] +id: GO:0035621 +name: ER to Golgi ceramide transport +namespace: biological_process +def: "The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:sart, PMID:14685229] +synonym: "endoplasmic reticulum to Golgi ceramide transport" EXACT [GOC:bf] +synonym: "ER to Golgi ceramide translocation" EXACT [PMID:14685229] +synonym: "non-vesicular ceramide trafficking" EXACT [PMID:14685229] +is_a: GO:0032365 ! intracellular lipid transport +is_a: GO:0035627 ! ceramide transport + +[Term] +id: GO:0035622 +name: intrahepatic bile duct development +namespace: biological_process +def: "The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver)." [GOC:bf, PMID:20614624] +synonym: "IHBD development" EXACT [PMID:20614624] +synonym: "intrahepatic biliary duct development" EXACT [PMID:20614624] +is_a: GO:0061009 ! common bile duct development +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0035623 +name: renal glucose absorption +namespace: biological_process +def: "A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf, PMID:11269503] +synonym: "glucose reabsorption" EXACT [GOC:yaf] +synonym: "nephron glucose absorption" EXACT [GOC:yaf] +is_a: GO:0070293 ! renal absorption +is_a: GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0035624 +name: receptor transactivation +namespace: biological_process +def: "The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer." [GOC:al, GOC:bf, GOC:BHF, PMID:16870826, PMID:21063387] +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0035625 +name: obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway +namespace: biological_process +def: "OBSOLETE. The process in which an epidermal growth factor-activated receptor is activated via signaling events from a consequence of a G protein-coupled . This is an example of cross-talk between the EGF and GPCR signaling pathways." [GOC:bf, GOC:BHF, PMID:10622253, PMID:17655843] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "EGFR transactivation by GPCR" EXACT [GOC:bf] +synonym: "EGFR transactivation upon GPCR stimulation" EXACT [PMID:10622253] +synonym: "epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway" EXACT [GOC:bf, GOC:signaling] +synonym: "epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signalling pathway" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0035626 +name: juvenile hormone mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity." [GOC:bf, GOC:sart] +synonym: "juvenile hormone mediated signalling pathway" EXACT [GOC:bf] +synonym: "juvenile hormone-mediated signaling pathway" EXACT [GOC:bf] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0035627 +name: ceramide transport +namespace: biological_process +def: "The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." [GOC:bf, GOC:sart] +is_a: GO:0006869 ! lipid transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0035628 +name: cystic duct development +namespace: biological_process +def: "The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct." [PMID:20614624] +is_a: GO:0061009 ! common bile duct development + +[Term] +id: GO:0035629 +name: N-terminal protein amino acid N-linked glycosylation +namespace: biological_process +def: "Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein." [GOC:bf, GOC:pr] +comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. +is_a: GO:0006487 ! protein N-linked glycosylation +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0035630 +name: bone mineralization involved in bone maturation +namespace: biological_process +def: "The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state." [GOC:bf, GOC:BHF] +comment: Bone mineralization can also occur after a fracture and as a response to stress; in these cases, consider using the term 'bone mineralization ; GO:0030282'. +is_a: GO:0030282 ! bone mineralization +relationship: part_of GO:0043931 ! ossification involved in bone maturation + +[Term] +id: GO:0035631 +name: CD40 receptor complex +namespace: cellular_component +def: "A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules." [GOC:BHF, PMID:20614026, PMID:9221764] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0035632 +name: mitochondrial prohibitin complex +namespace: cellular_component +def: "A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." [GOC:kmv, PMID:12237468, PMID:21164222] +synonym: "mitochondrial inner membrane prohibitin complex" EXACT [GOC:bf] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0035633 +name: maintenance of blood-brain barrier +namespace: biological_process +def: "Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation." [GOC:aruk, GOC:bc, GOC:bf, GOC:sl, PMID:20080302, PMID:30280653] +comment: Homeostasis and maintenance processes are regulatory processes, therefore, regulation child terms, such as: regulation of maintenance of blood-brain barrier, should not exist for these terms. \nInstead, for capturing regulation at the blood-brain barrier, consider using the part_of child term: regulation of blood-brain barrier permeability. +synonym: "maintenance of BBB" EXACT [] +synonym: "maintenance of blood/brain barrier" EXACT [] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0035634 +name: response to stilbenoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [GOC:yaf, Wikipedia:Stilbenoid] +subset: goslim_chembl +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0035635 +name: entry of bacterium into host cell +namespace: biological_process +def: "The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:21187937] +synonym: "bacterial entry into host cell" EXACT [GOC:bf] +synonym: "invasion of bacteria into host cell" EXACT [GOC:bf] +is_a: GO:0044409 ! entry into host + +[Term] +id: GO:0035636 +name: obsolete multi-organism signaling +namespace: biological_process +def: "OBSOLETE. The transfer of information between living organisms." [GOC:go_curators] +comment: This term was obsoleted because it was a grouping term but had no subclasses. +synonym: "multi-organism signalling" EXACT [GOC:bf] +synonym: "pheromone signaling" NARROW [GOC:bf] +synonym: "signaling between organisms" EXACT [GOC:bf] +synonym: "signaling with other organism" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0035637 +name: multicellular organismal signaling +namespace: biological_process +def: "The transfer of information occurring at the level of a multicellular organism." [GOC:go_curators] +synonym: "multicellular organismal signalling" EXACT [GOC:bf] +is_a: GO:0023052 ! signaling +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0035639 +name: purine ribonucleoside triphosphate binding +namespace: molecular_function +def: "Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:BHF, GOC:ebc, ISBN:0198506732] +synonym: "purine NTP binding" BROAD [GOC:ebc] +is_a: GO:0043168 ! anion binding +is_a: GO:1901265 ! nucleoside phosphate binding + +[Term] +id: GO:0035640 +name: exploration behavior +namespace: biological_process +def: "The specific behavior of an organism in response to a novel environment or stimulus." [GOC:BHF, GOC:pr, PMID:11682103, PMID:9767169] +comment: For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641. +synonym: "exploration behaviour" EXACT [GOC:bf] +synonym: "exploratory behavior" EXACT [PMID:20869398] +synonym: "exploratory behaviour" EXACT [PMID:11682103] +synonym: "open-field behavior" NARROW [PMID:11682103] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0035641 +name: locomotory exploration behavior +namespace: biological_process +def: "The specific movement from place to place of an organism in response to a novel environment." [GOC:sart, PMID:17151232] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0035640 ! exploration behavior + +[Term] +id: GO:0035642 +name: histone methyltransferase activity (H3-R17 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3." [GOC:sp, PMID:11341840] +synonym: "histone methylase activity (H3-R17 specific)" EXACT [GOC:bf] +synonym: "histone-arginine N-methyltransferase activity (H3-R17 specific)" EXACT [GOC:bf] +is_a: GO:0008469 ! histone-arginine N-methyltransferase activity + +[Term] +id: GO:0035643 +name: L-DOPA receptor activity +namespace: molecular_function +def: "Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine." [PMID:18828673, Wikipedia:L-DOPA] +synonym: "L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity" EXACT [] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0035644 +name: phosphoanandamide dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate groups from a phosphorylated anandamide." [GOC:BHF, PMID:16938887] +is_a: GO:0016311 ! dephosphorylation + +[Term] +id: GO:0035645 +name: enteric smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine." [CL:0002504, GOC:BHF] +synonym: "intestinal smooth muscle cell differentiation" EXACT [CL:0002504] +is_a: GO:0051145 ! smooth muscle cell differentiation +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0035646 +name: endosome to melanosome transport +namespace: biological_process +def: "The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle." [PMID:16162817] +is_a: GO:0043485 ! endosome to pigment granule transport + +[Term] +id: GO:0035647 +name: 3-oxo-delta(4,5)-steroid 5-beta-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+)." [GOC:kad, MetaCyc:RXN-9726, PMID:19166903] +synonym: "3-oxo-delta4,5-steroid 5beta-reductase" EXACT [GOC:kad] +is_a: GO:0035671 ! enone reductase activity + +[Term] +id: GO:0035648 +name: circadian mating behavior +namespace: biological_process +def: "The fluctuation in mating behavior that occurs over an approximately 24 hour cycle." [GOC:bf, GOC:dos, PMID:11470898, PMID:17276917] +synonym: "circadian mating behaviour" EXACT [GOC:bf] +synonym: "circadian mating rhythm" EXACT [GOC:dos] +is_a: GO:0007617 ! mating behavior +is_a: GO:0048512 ! circadian behavior + +[Term] +id: GO:0035649 +name: Nrd1 complex +namespace: cellular_component +def: "A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p." [GOC:jh, PMID:10655211, PMID:16427013, PMID:21084293] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0035650 +name: AP-1 adaptor complex binding +namespace: molecular_function +def: "Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [PMID:21097499] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0035651 +name: AP-3 adaptor complex binding +namespace: molecular_function +def: "Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [PMID:21097499] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0035652 +name: clathrin-coated vesicle cargo loading +namespace: biological_process +def: "Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle." [GOC:lb, PMID:16162817] +synonym: "cargo loading into clathrin-coated vesicle" EXACT [] +is_a: GO:0035459 ! vesicle cargo loading + +[Term] +id: GO:0035653 +name: clathrin-coated vesicle cargo loading, AP-1-mediated +namespace: biological_process +def: "Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking." [GOC:lb, PMID:12802059, PMID:16162817] +synonym: "cargo loading into clathrin-coated vesicle, AP-1-mediated" EXACT [] +is_a: GO:0035652 ! clathrin-coated vesicle cargo loading + +[Term] +id: GO:0035654 +name: clathrin-coated vesicle cargo loading, AP-3-mediated +namespace: biological_process +def: "Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle." [GOC:lb, PMID:12802059, PMID:16162817] +synonym: "cargo loading into clathrin-coated vesicle, AP-3-mediated" EXACT [] +is_a: GO:0035652 ! clathrin-coated vesicle cargo loading + +[Term] +id: GO:0035655 +name: interleukin-18-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:signaling] +synonym: "interleukin-18-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071351 ! cellular response to interleukin-18 + +[Term] +id: GO:0035656 +name: obsolete kinesin-associated melanosomal adaptor activity +namespace: molecular_function +def: "OBSOLETE. The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes." [PMID:19841138] +comment: This term was obsoleted because it represents the function of a specific protein. +synonym: "kinesin-melanosome adaptor activity" EXACT [GOC:bf] +is_obsolete: true +consider: GO:0008093 +consider: GO:0030674 + +[Term] +id: GO:0035657 +name: eRF1 methyltransferase complex +namespace: cellular_component +def: "A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p." [GOC:rb, PMID:17008308, PMID:20400505] +synonym: "eRF1 MTase complex" EXACT [PMID:17008308] +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0035658 +name: Mon1-Ccz1 complex +namespace: cellular_component +def: "A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p." [GOC:rb, PMID:20797862] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005770 ! late endosome + +[Term] +id: GO:0035659 +name: Wnt signaling pathway involved in wound healing, spreading of epidermal cells +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis." [GOC:BHF] +synonym: "Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [] +synonym: "Wnt receptor signalling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in wound healing, spreading of epidermal cells" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0035313 ! wound healing, spreading of epidermal cells + +[Term] +id: GO:0035660 +name: MyD88-dependent toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834, PMID:20385024] +synonym: "MyD88-dependent TLR4 signaling pathway" EXACT [GOC:bf] +synonym: "MyD88-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] +is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway +is_a: GO:0034142 ! toll-like receptor 4 signaling pathway + +[Term] +id: GO:0035661 +name: MyD88-dependent toll-like receptor 2 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response." [GOC:BHF, PMID:20385024] +synonym: "MyD88-dependent TLR2 signaling pathway" EXACT [GOC:bf] +synonym: "MyD88-dependent toll-like receptor 2 signalling pathway" EXACT [GOC:bf] +is_a: GO:0002755 ! MyD88-dependent toll-like receptor signaling pathway +is_a: GO:0034134 ! toll-like receptor 2 signaling pathway + +[Term] +id: GO:0035662 +name: Toll-like receptor 4 binding +namespace: molecular_function +def: "Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18304834] +synonym: "TLR4 binding" EXACT [GOC:bf] +is_a: GO:0035325 ! Toll-like receptor binding + +[Term] +id: GO:0035663 +name: Toll-like receptor 2 binding +namespace: molecular_function +def: "Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." [GOC:BHF] +synonym: "TLR2 binding" EXACT [GOC:bf] +is_a: GO:0035325 ! Toll-like receptor binding + +[Term] +id: GO:0035664 +name: TIRAP-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:11526399, PMID:11544529, PMID:12447442] +synonym: "MAL-dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] +synonym: "MyD88 adapter-like dependent toll-like receptor signaling pathway" EXACT [PMID:11544529] +synonym: "TIRAP-dependent TLR signaling pathway" EXACT [GOC:bf] +synonym: "TIRAP-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0035665 +name: TIRAP-dependent toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:12447441] +synonym: "MAL-dependent toll-like receptor 4 signaling pathway" EXACT [PMID:11544529] +synonym: "MyD88 adapter-like dependent toll-like receptor 4 signaling pathway" EXACT [GOC:11544529] +synonym: "TIRAP-dependent TLR4 signaling pathway" EXACT [GOC:bf] +synonym: "TIRAP-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] +is_a: GO:0034142 ! toll-like receptor 4 signaling pathway +is_a: GO:0035664 ! TIRAP-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0035666 +name: TRIF-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:12855817] +synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway" EXACT [PMID:12855817] +synonym: "TRIF-dependent TLR signaling pathway" EXACT [GOC:bf] +synonym: "TRIF-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0035667 +name: TRIF-dependent toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:18641322, PMID:20511708] +synonym: "Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway" EXACT [PMID:12855817] +synonym: "TRIF-dependent TLR4 signaling pathway" EXACT [GOC:bf] +synonym: "TRIF-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] +is_a: GO:0034142 ! toll-like receptor 4 signaling pathway +is_a: GO:0035666 ! TRIF-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0035668 +name: TRAM-dependent toll-like receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:BHF, PMID:14556004] +synonym: "TRAM-dependent TLR signaling pathway" EXACT [GOC:bf] +synonym: "TRAM-dependent toll-like receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0002756 ! MyD88-independent toll-like receptor signaling pathway + +[Term] +id: GO:0035669 +name: TRAM-dependent toll-like receptor 4 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response." [GOC:BHF, PMID:14556004, PMID:18297073] +synonym: "TRAM-dependent TLR4 signaling pathway" EXACT [GOC:bf] +synonym: "TRAM-dependent toll-like receptor 4 signalling pathway" EXACT [GOC:bf] +is_a: GO:0034142 ! toll-like receptor 4 signaling pathway +is_a: GO:0035668 ! TRAM-dependent toll-like receptor signaling pathway + +[Term] +id: GO:0035670 +name: plant-type ovary development +namespace: biological_process +def: "The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed." [GOC:bf, GOC:tb, ISBN:0879015322] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0035671 +name: enone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+." [EC:1.3.1.-, GOC:kad, PMID:17945329, PMID:19166903] +xref: MetaCyc:RXN-12267 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0035672 +name: oligopeptide transmembrane transport +namespace: biological_process +def: "The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "oligopeptide membrane transport" EXACT [] +is_a: GO:0006857 ! oligopeptide transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0035673 +name: oligopeptide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015198 +def: "Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:vw, ISBN:0198506732] +synonym: "oligopeptide transporter activity" RELATED [] +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0035674 +name: tricarboxylic acid transmembrane transport +namespace: biological_process +def: "The process in which a tricarboxylic acid is transported across a membrane." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "tricarboxylic acid membrane transport" EXACT [] +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0035675 +name: neuromast hair cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0000856] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0048886 ! neuromast hair cell differentiation + +[Term] +id: GO:0035676 +name: anterior lateral line neuromast hair cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509, ISBN:0387968377] +is_a: GO:0035675 ! neuromast hair cell development +relationship: part_of GO:0048903 ! anterior lateral line neuromast hair cell differentiation + +[Term] +id: GO:0035677 +name: posterior lateral line neuromast hair cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate." [ISBN:0125296509] +is_a: GO:0035675 ! neuromast hair cell development +relationship: part_of GO:0048923 ! posterior lateral line neuromast hair cell differentiation + +[Term] +id: GO:0035678 +name: neuromast hair cell morphogenesis +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [CL:0000856] +is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation +relationship: part_of GO:0035675 ! neuromast hair cell development + +[Term] +id: GO:0035679 +name: anterior lateral line neuromast hair cell morphogenesis +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509, ISBN:0387968377] +is_a: GO:0035678 ! neuromast hair cell morphogenesis +relationship: part_of GO:0035676 ! anterior lateral line neuromast hair cell development + +[Term] +id: GO:0035680 +name: posterior lateral line neuromast hair cell morphogenesis +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [ISBN:0125296509] +is_a: GO:0035678 ! neuromast hair cell morphogenesis +relationship: part_of GO:0035677 ! posterior lateral line neuromast hair cell development + +[Term] +id: GO:0035681 +name: toll-like receptor 15 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 15." [GOC:pde] +synonym: "TLR15 signaling pathway" EXACT [GOC:bf] +synonym: "toll-like receptor 15 signalling pathway" EXACT [GOC:mah] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0035682 +name: toll-like receptor 21 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to toll-like receptor 21." [GOC:pde] +synonym: "TLR21 signaling pathway" EXACT [GOC:bf] +synonym: "toll-like receptor 21 signalling pathway" EXACT [GOC:mah] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0035683 +name: memory T cell extravasation +namespace: biological_process +def: "The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive." [CL:0000813, GOC:BHF] +synonym: "memory T-cell extravasation" EXACT [GOC:ebc] +is_a: GO:0072683 ! T cell extravasation + +[Term] +id: GO:0035684 +name: helper T cell extravasation +namespace: biological_process +def: "The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells." [CL:0000912, GOC:BHF] +synonym: "helper T-cell extravasation" EXACT [GOC:ebc] +synonym: "T-helper cell extravasation" EXACT [CL:0000912] +is_a: GO:0072683 ! T cell extravasation + +[Term] +id: GO:0035685 +name: helper T cell diapedesis +namespace: biological_process +def: "The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [CL:0000912, GOC:BHF] +synonym: "helper T-cell diapedesis" EXACT [CL:0000912] +synonym: "T-helper cell diapedesis" EXACT [CL:0000912] +is_a: GO:0050904 ! diapedesis +is_a: GO:0072678 ! T cell migration +relationship: part_of GO:0035684 ! helper T cell extravasation + +[Term] +id: GO:0035686 +name: sperm fibrous sheath +namespace: cellular_component +def: "A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat." [GOC:BHF, GOC:cilia, GOC:krc, PMID:20731842, PMID:3282552] +synonym: "flagellar fibrous sheath" EXACT [] +synonym: "flagellum fibrous sheath" EXACT [GOC:bf] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0035687 +name: T-helper 1 cell extravasation +namespace: biological_process +def: "The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF] +synonym: "Th1 cell extravasation" EXACT [CL:0000545] +is_a: GO:0035684 ! helper T cell extravasation +is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:0035688 +name: T-helper 1 cell diapedesis +namespace: biological_process +def: "The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:BHF, PMID:10477596] +synonym: "Th1 cell diapedesis" EXACT [CL:0000545] +is_a: GO:0035685 ! helper T cell diapedesis +relationship: part_of GO:0035687 ! T-helper 1 cell extravasation + +[Term] +id: GO:0035689 +name: chemokine (C-C motif) ligand 5 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:18337562] +synonym: "CCL5-mediated signaling pathway" EXACT [PMID:18337562] +synonym: "chemokine (C-C motif) ligand 5 signalling pathway" EXACT [GOC:mah] +synonym: "RANTES-mediated signaling pathway" EXACT [PMID:19122644] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0035691 +name: macrophage migration inhibitory factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:12782713, PMID:19413900] +synonym: "macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] +synonym: "MIF signaling pathway" EXACT [GOC:ebc] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0035692 +name: macrophage migration inhibitory factor receptor complex +namespace: cellular_component +def: "A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins." [GOC:BHF, PMID:12782713, PMID:17045821] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0035693 +name: NOS2-CD74 complex +namespace: cellular_component +def: "A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases." [GOC:BHF, PMID:18003616] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0035694 +name: mitochondrial protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure." [GOC:sp, PMID:21264221, PMID:21264228] +synonym: "catabolism of mitochondrial protein" EXACT [GOC:bf] +synonym: "degradation of damaged mitochondrial protein" EXACT [GOC:bf] +is_a: GO:0044257 ! cellular protein catabolic process +relationship: part_of GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0035695 +name: mitophagy by induced vacuole formation +namespace: biological_process +def: "The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes." [GOC:autophagy, GOC:bf, GOC:sp, PMID:21264228] +comment: In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome. +synonym: "MIV-mediated mitophagy" NARROW [PMID:21264228] +is_a: GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:0035696 +name: monocyte extravasation +namespace: biological_process +def: "The migration of a monocyte from the blood vessels into the surrounding tissue." [CL:0000576, GOC:BHF, PMID:10657654] +is_a: GO:0045123 ! cellular extravasation +is_a: GO:0071674 ! mononuclear cell migration +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:0035697 +name: CD8-positive, alpha-beta T cell extravasation +namespace: biological_process +def: "The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue." [CL:0000625, GOC:BHF] +is_a: GO:0072683 ! T cell extravasation + +[Term] +id: GO:0035698 +name: CD8-positive, alpha-beta cytotoxic T cell extravasation +namespace: biological_process +def: "The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue." [CL:0000794, GOC:BHF] +is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:0035699 +name: T-helper 17 cell extravasation +namespace: biological_process +def: "The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue." [CL:0000899, GOC:BHF] +is_a: GO:0035684 ! helper T cell extravasation +is_a: GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:0035700 +name: astrocyte chemotaxis +namespace: biological_process +def: "The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000127, GOC:BHF, PMID:12271471] +is_a: GO:0043615 ! astrocyte cell migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0035701 +name: hematopoietic stem cell migration +namespace: biological_process +def: "The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:BHF, PMID:20234092] +synonym: "hemopoietic stem cell migration" EXACT [CL:0000037] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0035702 +name: monocyte homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000576, GOC:BHF, PMID:18832716] +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0035703 +name: monocyte migration into blood stream +namespace: biological_process +def: "The movement of a monocyte from the bone marrow to the blood stream." [CL:0000576, GOC:BHF] +synonym: "release of monocytes into circulation" EXACT [GOC:bf] +is_a: GO:0071674 ! mononuclear cell migration +is_a: GO:0097529 ! myeloid leukocyte migration +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0035704 +name: helper T cell chemotaxis +namespace: biological_process +def: "The directed movement of a helper T cell in response to an external stimulus." [CL:0000912, GOC:BHF] +synonym: "T-helper cell chemotaxis" EXACT [CL:0000912] +is_a: GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0035705 +name: T-helper 17 cell chemotaxis +namespace: biological_process +def: "The directed movement of a T-helper 17 cell in response to an external stimulus." [CL:0000899, GOC:BHF] +synonym: "Th17 cell chemotaxis" EXACT [CL:0000899] +is_a: GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0035706 +name: T-helper 1 cell chemotaxis +namespace: biological_process +def: "The directed movement of a T-helper 1 cell in response to an external stimulus." [CL:0000545, GOC:BHF] +synonym: "Th1 cell chemotaxis" EXACT [CL:0000545] +is_a: GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0035707 +name: T-helper 2 cell chemotaxis +namespace: biological_process +def: "The directed movement of a T-helper 2 cell in response to an external stimulus." [CL:0000546, GOC:BHF] +synonym: "Th2 cell chemotaxis" EXACT [CL:0000546] +is_a: GO:0010818 ! T cell chemotaxis + +[Term] +id: GO:0035708 +name: interleukin-4-dependent isotype switching to IgE isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4)." [GOC:BHF, PMID:12496423] +synonym: "IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:add, GOC:bf] +is_a: GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0035709 +name: memory T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000813, GOC:BHF] +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0035710 +name: CD4-positive, alpha-beta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000624, GOC:BHF] +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0035711 +name: T-helper 1 cell activation +namespace: biological_process +def: "The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000545, GOC:BHF] +synonym: "Th1 cell activation" EXACT [CL:0000545] +is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:0035712 +name: T-helper 2 cell activation +namespace: biological_process +def: "The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000546, GOC:BHF] +synonym: "Th2 cell activation" EXACT [CL:0000546] +is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:0035713 +name: response to nitrogen dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF] +synonym: "response to NO2" EXACT [] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0035714 +name: cellular response to nitrogen dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus." [GOC:BHF] +synonym: "cellular response to NO2" EXACT [] +is_a: GO:0035713 ! response to nitrogen dioxide +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0035715 +name: chemokine (C-C motif) ligand 2 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 2." [GOC:BHF] +synonym: "CCL2 binding" EXACT [GOC:ebc] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0035716 +name: chemokine (C-C motif) ligand 12 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 12." [GOC:BHF] +synonym: "CCL12 binding" EXACT [GOC:ebc] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0035717 +name: chemokine (C-C motif) ligand 7 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 7." [GOC:BHF] +synonym: "CCL7 binding" EXACT [GOC:ebc] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0035718 +name: macrophage migration inhibitory factor binding +namespace: molecular_function +def: "Binding to the cytokine, macrophage migration inhibitory factor." [GOC:BHF, PMID:19601712] +synonym: "MIF binding" EXACT [PMID:19601712] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0035719 +name: tRNA import into nucleus +namespace: biological_process +def: "The directed movement of tRNA from the cytoplasm to the nucleus." [GOC:vw, PMID:20032305] +synonym: "retrograde tRNA transport into nucleus" EXACT [GOC:vw, PMID:20032305] +synonym: "tRNA nuclear import" EXACT [GOC:vw] +is_a: GO:0006404 ! RNA import into nucleus +is_a: GO:0051031 ! tRNA transport + +[Term] +id: GO:0035720 +name: intraciliary anterograde transport +namespace: biological_process +def: "The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins." [GOC:BHF, GOC:cilia, PMID:17895364] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "intraflagellar anterograde transport" EXACT [] +is_a: GO:0042073 ! intraciliary transport + +[Term] +id: GO:0035721 +name: intraciliary retrograde transport +namespace: biological_process +def: "The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins." [GOC:BHF, GOC:cilia] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "intraflagellar retrograde transport" EXACT [] +is_a: GO:0042073 ! intraciliary transport + +[Term] +id: GO:0035722 +name: interleukin-12-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] +synonym: "IL-12-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-12-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071349 ! cellular response to interleukin-12 + +[Term] +id: GO:0035723 +name: interleukin-15-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] +synonym: "IL-15-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-15-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071350 ! cellular response to interleukin-15 + +[Term] +id: GO:0035724 +name: CD24 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation." [GOC:BHF] +synonym: "CD24 anabolism" EXACT [GOC:bf] +synonym: "CD24 biosynthesis" EXACT [GOC:bf] +synonym: "CD24 formation" EXACT [GOC:bf] +synonym: "CD24 synthesis" EXACT [GOC:bf] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0035725 +name: sodium ion transmembrane transport +namespace: biological_process +def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "sodium ion membrane transport" EXACT [] +is_a: GO:0006814 ! sodium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0035726 +name: common myeloid progenitor cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage." [CL:0000049, GOC:BHF] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0035727 +name: lysophosphatidic acid binding +namespace: molecular_function +def: "Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors." [GOC:curators] +synonym: "LPA binding" EXACT [] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0043168 ! anion binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0035728 +name: response to hepatocyte growth factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] +synonym: "response to hepatocyte growth factor stimulus" EXACT [GOC:dos] +synonym: "response to HGF stimulus" EXACT [GOC:bf] +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0035729 +name: cellular response to hepatocyte growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." [GOC:bf] +synonym: "cellular response to HGF stimulus" EXACT [GOC:bf] +is_a: GO:0035728 ! response to hepatocyte growth factor +is_a: GO:0071363 ! cellular response to growth factor stimulus + +[Term] +id: GO:0035730 +name: S-nitrosoglutathione binding +namespace: molecular_function +def: "Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems." [GOC:BHF] +synonym: "GSNO binding" EXACT [] +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0035731 +name: dinitrosyl-iron complex binding +namespace: molecular_function +def: "Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO." [GOC:BHF, PMID:10534443] +synonym: "dinitrosyl-diglutathionyl-iron complex binding" EXACT [PMID:12871931] +synonym: "DNDGIC binding" EXACT [PMID:12871931] +synonym: "DNIC binding" EXACT [PMID:10534443] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0035732 +name: nitric oxide storage +namespace: biological_process +def: "The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins." [GOC:BHF, PMID:12871945] +synonym: "NO storage" EXACT [GOC:bf] +is_a: GO:0051179 ! localization +relationship: part_of GO:0033484 ! nitric oxide homeostasis + +[Term] +id: GO:0035733 +name: hepatic stellate cell activation +namespace: biological_process +def: "A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor." [CL:0000632, GOC:bf] +is_a: GO:0072537 ! fibroblast activation + +[Term] +id: GO:0035735 +name: intraciliary transport involved in cilium assembly +namespace: biological_process +def: "The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." [GOC:bf, GOC:cilia, Reactome:R-HSA-5620924.2] +synonym: "intraciliary transport involved in cilium morphogenesis" RELATED [] +synonym: "intraflagellar transport" BROAD [] +synonym: "intraflagellar transport involved in cilium morphogenesis" RELATED [] +xref: Reactome:R-HSA-5620924.2 +is_a: GO:0042073 ! intraciliary transport +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:0035736 +name: cell proliferation involved in compound eye morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." [GOC:bf, GOC:sart] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0035737 +name: injection of substance in to other organism +namespace: biological_process +def: "The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes." [GOC:pamgo_curators] +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0035738 +name: envenomation resulting in modulation of process in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism." [GOC:pamgo_curators] +synonym: "envenomation resulting in modification of morphology or physiology of other organism" EXACT [] +synonym: "envenomation resulting in modulation of process in other organism" EXACT [] +is_a: GO:0035737 ! injection of substance in to other organism + +[Term] +id: GO:0035739 +name: CD4-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of a CD4-positive, alpha-beta T cell population by cell division." [CL:0000624, GOC:BHF] +is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation +is_a: GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0035740 +name: CD8-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of a CD8-positive, alpha-beta T cell population by cell division." [CL:0000625, GOC:BHF] +is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation +is_a: GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0035741 +name: activated CD4-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of an activated CD4-positive, alpha-beta T cell population by cell division." [CL:0000896, GOC:BHF] +is_a: GO:0035739 ! CD4-positive, alpha-beta T cell proliferation + +[Term] +id: GO:0035742 +name: activated CD8-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of an activated CD8-positive, alpha-beta T cell population by cell division." [CL:0000906, GOC:BHF] +is_a: GO:0035740 ! CD8-positive, alpha-beta T cell proliferation + +[Term] +id: GO:0035743 +name: CD4-positive, alpha-beta T cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell." [CL:0000624, GOC:BHF] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002369 ! T cell cytokine production + +[Term] +id: GO:0035744 +name: T-helper 1 cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a T-helper 1 cell." [CL:0000545, GOC:BHF] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "Th1 cell cytokine production" EXACT [CL:0000545] +is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production +relationship: part_of GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0035745 +name: T-helper 2 cell cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a T-helper 2 cell." [CL:0000546, GOC:BHF] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "Th2 cell cytokine production" EXACT [CL:0000546] +is_a: GO:0035743 ! CD4-positive, alpha-beta T cell cytokine production +relationship: part_of GO:0042092 ! type 2 immune response + +[Term] +id: GO:0035746 +name: granzyme A production +namespace: biological_process +def: "The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0035747 +name: natural killer cell chemotaxis +namespace: biological_process +def: "The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000623, GOC:BHF] +is_a: GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0035748 +name: myelin sheath abaxonal region +namespace: cellular_component +def: "The region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0035749 +name: myelin sheath adaxonal region +namespace: cellular_component +def: "The region of the myelin sheath nearest to the axon." [GOC:BHF, PMID:20237282] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0035750 +name: protein localization to myelin sheath abaxonal region +namespace: biological_process +def: "Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon." [GOC:BHF, PMID:20237282] +synonym: "protein localisation to myelin sheath abaxonal region" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0035751 +name: regulation of lysosomal lumen pH +namespace: biological_process +def: "Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:rph] +is_a: GO:0051453 ! regulation of intracellular pH +relationship: part_of GO:0007040 ! lysosome organization + +[Term] +id: GO:0035752 +name: lysosomal lumen pH elevation +namespace: biological_process +def: "Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:bf, GOC:rph] +synonym: "lysosome pH elevation" EXACT [GOC:bf, GOC:rph] +is_a: GO:0035751 ! regulation of lysosomal lumen pH +is_a: GO:0051454 ! intracellular pH elevation + +[Term] +id: GO:0035753 +name: maintenance of DNA trinucleotide repeats +namespace: biological_process +def: "Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs." [GOC:rb, PMID:21347277, SO:0000291] +is_a: GO:0043570 ! maintenance of DNA repeat elements + +[Term] +id: GO:0035754 +name: B cell chemotaxis +namespace: biological_process +def: "The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000236, GOC:BHF] +is_a: GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0035755 +name: cardiolipin hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA)." [GOC:sp, PMID:17028579, PMID:21397848] +xref: Reactome:R-HSA-8954398 "PLD6 dimer hydrolyses cardiolipin to PA and PG" +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0035756 +name: transepithelial migration of symbiont in host +namespace: biological_process +def: "The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, PMID:10639460] +synonym: "migration in host through an epithelial cell layer" EXACT [GOC:bf] +synonym: "migration of symbiont within host by transepithelial trafficking" EXACT [GOC:bf] +synonym: "transmigration of symbiont in host" RELATED [] +is_a: GO:0044001 ! migration in host + +[Term] +id: GO:0035757 +name: chemokine (C-C motif) ligand 19 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 19." [GOC:BHF] +synonym: "CCL19 binding" EXACT [GOC:bf] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0035758 +name: chemokine (C-C motif) ligand 21 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 21." [GOC:BHF] +synonym: "CCL21 binding" EXACT [GOC:bf] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0035759 +name: mesangial cell-matrix adhesion +namespace: biological_process +def: "The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney." [CL:0000650, GOC:BHF, PMID:15569314] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0035760 +name: cytoplasmic polyadenylation-dependent rRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate." [PMID:20368444] +synonym: "cytoplasmic poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0016075 ! rRNA catabolic process +is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0035761 +name: dorsal motor nucleus of vagus nerve maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state." [GOC:dgh] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development + +[Term] +id: GO:0035762 +name: dorsal motor nucleus of vagus nerve morphogenesis +namespace: biological_process +def: "The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dgh] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021744 ! dorsal motor nucleus of vagus nerve development + +[Term] +id: GO:0035763 +name: dorsal motor nucleus of vagus nerve structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "dorsal motor nucleus of vagus nerve structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis + +[Term] +id: GO:0035764 +name: dorsal motor nucleus of vagus nerve formation +namespace: biological_process +def: "The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035762 ! dorsal motor nucleus of vagus nerve morphogenesis + +[Term] +id: GO:0035765 +name: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation +namespace: biological_process +def: "The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve." [GOC:dgh, PMID:21262462] +is_a: GO:0021535 ! cell migration in hindbrain +relationship: part_of GO:0035764 ! dorsal motor nucleus of vagus nerve formation + +[Term] +id: GO:0035766 +name: cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF)." [GOC:BHF] +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus + +[Term] +id: GO:0035767 +name: endothelial cell chemotaxis +namespace: biological_process +def: "The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [CL:0000115, GOC:BHF] +is_a: GO:0043542 ! endothelial cell migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0035768 +name: endothelial cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF)." [CL:0000115, GOC:BHF] +is_a: GO:0035766 ! cell chemotaxis to fibroblast growth factor +is_a: GO:0035767 ! endothelial cell chemotaxis + +[Term] +id: GO:0035769 +name: B cell chemotaxis across high endothelial venule +namespace: biological_process +def: "The movement of a B cell to cross a high endothelial venule in response to an external stimulus." [CL:0000236, GOC:BHF] +synonym: "B-cell chemotaxis across high endothelial venule" EXACT [GOC:ebc] +is_a: GO:0002518 ! lymphocyte chemotaxis across high endothelial venule +is_a: GO:0035754 ! B cell chemotaxis + +[Term] +id: GO:0035770 +name: ribonucleoprotein granule +namespace: cellular_component +def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] +synonym: "mRNP granule" EXACT [] +synonym: "RNA granule" NARROW [] +synonym: "RNP granule" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0099080 ! supramolecular complex + +[Term] +id: GO:0035771 +name: interleukin-4-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] +synonym: "IL-4-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-4-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071353 ! cellular response to interleukin-4 + +[Term] +id: GO:0035772 +name: interleukin-13-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling] +synonym: "IL-13-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-13-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0035963 ! cellular response to interleukin-13 + +[Term] +id: GO:0035773 +name: insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus." [GOC:bf, GOC:yaf, PMID:8492079] +synonym: "insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] +is_a: GO:0030073 ! insulin secretion +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0071333 ! cellular response to glucose stimulus + +[Term] +id: GO:0035774 +name: positive regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:bf, GOC:yaf] +synonym: "positive regulation of insulin secretion in response to glucose" EXACT [GOC:bf] +is_a: GO:0032024 ! positive regulation of insulin secretion +is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus +relationship: positively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus + +[Term] +id: GO:0035775 +name: pronephric glomerulus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] +comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. +is_a: GO:0072102 ! glomerulus morphogenesis +relationship: part_of GO:0039021 ! pronephric glomerulus development + +[Term] +id: GO:0035776 +name: pronephric proximal tubule development +namespace: biological_process +def: "The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] +is_a: GO:0039020 ! pronephric nephron tubule development +is_a: GO:0072014 ! proximal tubule development + +[Term] +id: GO:0035777 +name: pronephric distal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] +is_a: GO:0039020 ! pronephric nephron tubule development +is_a: GO:0072017 ! distal tubule development + +[Term] +id: GO:0035778 +name: pronephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:18787069] +is_a: GO:0039014 ! cell differentiation involved in pronephros development +is_a: GO:0072160 ! nephron tubule epithelial cell differentiation +relationship: part_of GO:0039020 ! pronephric nephron tubule development + +[Term] +id: GO:0035779 +name: angioblast cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells)." [CL:0000566, GOC:yaf] +synonym: "angioblastic mesenchymal cell differentiation" EXACT [CL:0000566] +is_a: GO:0048863 ! stem cell differentiation +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0035780 +name: CD80 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] +synonym: "CD80 anabolism" EXACT [GOC:bf] +synonym: "CD80 biosynthesis" EXACT [GOC:bf] +synonym: "CD80 formation" EXACT [GOC:bf] +synonym: "CD80 synthesis" EXACT [GOC:bf] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0035781 +name: CD86 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival." [GOC:BHF, GOC:ebc] +synonym: "CD86 anabolism" EXACT [GOC:bf] +synonym: "CD86 biosynthesis" EXACT [GOC:bf] +synonym: "CD86 formation" EXACT [GOC:bf] +synonym: "CD86 synthesis" EXACT [GOC:bf] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0035782 +name: mature natural killer cell chemotaxis +namespace: biological_process +def: "The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules." [CL:0000824, GOC:BHF] +synonym: "activated natural killer cell chemotaxis" EXACT [GOC:ebc] +is_a: GO:0035747 ! natural killer cell chemotaxis + +[Term] +id: GO:0035783 +name: CD4-positive, alpha-beta T cell costimulation +namespace: biological_process +def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation." [CL:0000624, GOC:BHF, GOC:pr] +synonym: "CD4-positive, alpha beta T cell costimulation" EXACT [] +is_a: GO:0031295 ! T cell costimulation +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:0035784 +name: nickel cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell." [GOC:kmv] +synonym: "nickel homeostasis" EXACT [GOC:bf] +is_a: GO:0055076 ! transition metal ion homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0035785 +name: cellular nickel ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell." [GOC:kmv] +synonym: "cellular nickel homeostasis" EXACT [GOC:bf] +is_a: GO:0035784 ! nickel cation homeostasis +is_a: GO:0046916 ! cellular transition metal ion homeostasis +is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis + +[Term] +id: GO:0035787 +name: cell migration involved in kidney development +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0035788 +name: cell migration involved in metanephros development +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf] +synonym: "cell migration involved in metanephric kidney development" EXACT [GOC:bf] +is_a: GO:0035787 ! cell migration involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0035789 +name: metanephric mesenchymal cell migration +namespace: biological_process +def: "The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101, PMID:19019919] +synonym: "metanephric mesenchyme chemotaxis" NARROW [PMID:19019919] +is_a: GO:0035788 ! cell migration involved in metanephros development + +[Term] +id: GO:0035790 +name: platelet-derived growth factor receptor-alpha signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:yaf, PMID:10372961] +synonym: "alphaPDGF receptor signaling pathway" EXACT [PMID:10372961] +synonym: "PDGF receptor-alpha signaling pathway" EXACT [GOC:bf] +synonym: "PDGFR-alpha signaling pathway" RELATED [GOC:bf] +synonym: "platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] +is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0035791 +name: platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, GOC:yaf, PMID:10372961] +synonym: "betaPDGF receptor signaling pathway" EXACT [PMID:10372961] +synonym: "PDGF receptor-beta signaling pathway" EXACT [GOC:bf] +synonym: "PDGFR-beta signaling pathway" EXACT [GOC:bf] +synonym: "platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0035792 +name: host cell postsynaptic membrane +namespace: cellular_component +def: "A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane." [GOC:ecd] +synonym: "other organism post-synaptic membrane" EXACT [] +synonym: "other organism postsynaptic membrane" RELATED [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0033644 ! host cell membrane + +[Term] +id: GO:0035793 +name: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:10734101] +synonym: "positive regulation of metanephric mesenchymal cell migration by betaPDGF receptor signaling pathway" EXACT [PMID:10734101] +synonym: "positive regulation of metanephric mesenchymal cell migration by PDGF receptor-beta signaling pathway" EXACT [GOC:bf] +synonym: "positive regulation of metanephric mesenchymal cell migration by PDGFR-beta signaling pathway" EXACT [GOC:bf] +synonym: "positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +is_a: GO:1900238 ! regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway +is_a: GO:2000591 ! positive regulation of metanephric mesenchymal cell migration + +[Term] +id: GO:0035794 +name: positive regulation of mitochondrial membrane permeability +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf, PMID:12546810] +synonym: "mitochondrial membrane permeability transition" NARROW [PMID:17136322] +synonym: "mitochondrial membrane permeabilization" NARROW [PMID:12546810] +synonym: "mitochondrial permeability transition" NARROW [PMID:21424245] +synonym: "MPT" NARROW [] +synonym: "positive regulation of transport across mitochondrial membrane" EXACT [GOC:bf] +is_a: GO:0046902 ! regulation of mitochondrial membrane permeability +is_a: GO:1905710 ! positive regulation of membrane permeability + +[Term] +id: GO:0035795 +name: negative regulation of mitochondrial membrane permeability +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [PMID:10781072] +synonym: "mitochondrial membrane impermeability" RELATED [PMID:10781072] +synonym: "mitochondrial membrane impermeabilization" NARROW [GOC:bf] +synonym: "negative regulation of transport across mitochondrial membrane" EXACT [GOC:bf] +is_a: GO:0046902 ! regulation of mitochondrial membrane permeability +is_a: GO:1905709 ! negative regulation of membrane permeability + +[Term] +id: GO:0035796 +name: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing +namespace: cellular_component +def: "A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [PMID:18931129, PMID:20972419, PMID:21135102] +comment: The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane. +synonym: "ATP-binding cassette (ABC) transporter complex, ECF-type" EXACT [GOC:bf] +synonym: "energy coupling factor (ECF)-type ABC transporter" EXACT [PMID:21135102] +synonym: "energy-coupling factor transporter" EXACT [PMID:18931129] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:0035797 +name: tellurite methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride)." [GOC:bf, GOC:kad, PMID:11053398, PMID:21244361] +synonym: "S-adenosyl-L-methionine-dependent tellurite methyltransferase activity" EXACT [GOC:bf] +synonym: "SAM-dependent tellurite methyltransferase activity" EXACT [GOC:bf] +synonym: "tellurite methylase activity" BROAD [GOC:bf] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0035798 +name: 2-alkenal reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+." [GOC:bf, GOC:kad, PMID:16299173] +synonym: "NADPH:2-alkenal alpha,beta-hydrogenase activity" EXACT [GOC:bf, GOC:kad] +is_a: GO:0032440 ! 2-alkenal reductase [NAD(P)+] activity + +[Term] +id: GO:0035799 +name: ureter maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:17881463] +is_a: GO:0048799 ! animal organ maturation +relationship: part_of GO:0072189 ! ureter development + +[Term] +id: GO:0035800 +name: deubiquitinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences." [GOC:sart, ISBN:0120793709] +is_a: GO:0016504 ! peptidase activator activity + +[Term] +id: GO:0035801 +name: adrenal cortex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens)." [PMID:12185666, PMID:21115154, Wikipedia:Adrenal_cortex] +synonym: "adrenal gland cortex development" EXACT [MA:0000118] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030325 ! adrenal gland development + +[Term] +id: GO:0035802 +name: adrenal cortex formation +namespace: biological_process +def: "The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate)." [PMID:12185666, PMID:21115154] +synonym: "adrenal gland cortex formation" EXACT [MA:0000118] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035801 ! adrenal cortex development + +[Term] +id: GO:0035803 +name: egg coat formation +namespace: biological_process +def: "Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [GOC:bf, GOC:sart, GOC:yaf, PMID:16944418, PMID:17163408] +synonym: "VE formation" NARROW [PMID:16944418, PMID:17163408] +synonym: "vitelline envelope formation" NARROW [PMID:16944418] +synonym: "zona pellucida assembly" NARROW [GOC:yaf, PMID:18420282] +synonym: "ZP assembly" NARROW [PMID:18420282] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0035804 +name: structural constituent of egg coat +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] +synonym: "structural constituent of vitelline envelope" NARROW [PMID:16944418, PMID:17163408] +synonym: "structural constituent of zona pellucida" NARROW [PMID:16944418, PMID:17163408] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0035805 +name: egg coat +namespace: cellular_component +def: "A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development." [PMID:16944418, PMID:17163408] +synonym: "vitelline membrane" NARROW [PMID:16944418, PMID:17163408] +synonym: "zona pellucida" NARROW [PMID:16944418, PMID:17163408] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0035806 +name: modulation of blood coagulation in another organism +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj] +synonym: "modulation by organism of blood clotting in other organism" EXACT [GOC:bf] +synonym: "modulation by organism of blood coagulation in other organism" EXACT [GOC:bf] +synonym: "modulation of blood coagulation in other organism" EXACT [GOC:bf] +synonym: "regulation by organism of blood clotting in other organism" EXACT [GOC:bf] +synonym: "regulation of blood clotting in other organism" EXACT [GOC:bf] +synonym: "regulation of blood coagulation in other organism" EXACT [GOC:bf] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0035807 +name: positive regulation of blood coagulation in another organism +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:bf, GOC:fj, PMID:12362232] +synonym: "positive regulation by organism of blood clotting in other organism" EXACT [GOC:bf] +synonym: "positive regulation by organism of blood coagulation in other organism" EXACT [GOC:bf] +synonym: "positive regulation of blood clotting in other organism" EXACT [GOC:bf] +synonym: "positive regulation of blood coagulation in other organism" EXACT [] +is_a: GO:0030194 ! positive regulation of blood coagulation +is_a: GO:0035806 ! modulation of blood coagulation in another organism + +[Term] +id: GO:0035808 +name: meiotic recombination initiation complex +namespace: cellular_component +def: "A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins." [GOC:vw, PMID:12897161, PMID:20364342, PMID:21429938] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0035809 +name: regulation of urine volume +namespace: biological_process +def: "Any process that modulates the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] +synonym: "regulation of urinary volume" EXACT [] +synonym: "regulation of urine flow" EXACT [] +is_a: GO:0003014 ! renal system process +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0035810 +name: positive regulation of urine volume +namespace: biological_process +def: "Any process that increases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] +synonym: "diuresis" BROAD [GOC:mtg_25march11] +synonym: "elevation of urinary volume" EXACT [GOC:mtg_25march11] +synonym: "increase in urine flow" EXACT [GOC:mtg_25march11] +is_a: GO:0035809 ! regulation of urine volume + +[Term] +id: GO:0035811 +name: negative regulation of urine volume +namespace: biological_process +def: "Any process that decreases the amount of urine excreted from the body over a unit of time." [GOC:mtg_25march11, GOC:yaf] +synonym: "antidiuresis" BROAD [GOC:mtg_25march11] +synonym: "decrease in urine flow" EXACT [GOC:mtg_25march11] +synonym: "reduction of urinary volume" EXACT [GOC:mtg_25march11] +is_a: GO:0035809 ! regulation of urine volume + +[Term] +id: GO:0035812 +name: renal sodium excretion +namespace: biological_process +def: "The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:mtg_25march11, GOC:yaf, PMID:25287933] +is_a: GO:0097254 ! renal tubular secretion +relationship: part_of GO:0055078 ! sodium ion homeostasis + +[Term] +id: GO:0035813 +name: regulation of renal sodium excretion +namespace: biological_process +def: "Any process that modulates the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] +is_a: GO:0044062 ! regulation of excretion +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0035812 ! renal sodium excretion + +[Term] +id: GO:0035814 +name: negative regulation of renal sodium excretion +namespace: biological_process +def: "Any process that decreases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] +comment: The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine. +is_a: GO:0035813 ! regulation of renal sodium excretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035812 ! renal sodium excretion + +[Term] +id: GO:0035815 +name: positive regulation of renal sodium excretion +namespace: biological_process +def: "Any process that increases the amount of sodium excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] +comment: The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine. +synonym: "natriuresis" BROAD [GOC:mtg_25march11] +is_a: GO:0035813 ! regulation of renal sodium excretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0035812 ! renal sodium excretion + +[Term] +id: GO:0035816 +name: renal water absorption involved in negative regulation of urine volume +namespace: biological_process +def: "Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time." [GOC:mtg_25march11, GOC:yaf] +is_a: GO:0070295 ! renal water absorption +relationship: part_of GO:0035811 ! negative regulation of urine volume + +[Term] +id: GO:0035817 +name: renal sodium ion absorption involved in negative regulation of renal sodium excretion +namespace: biological_process +def: "Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time." [GOC:mtg_25march11, GOC:yaf] +is_a: GO:0070294 ! renal sodium ion absorption +relationship: part_of GO:0035814 ! negative regulation of renal sodium excretion + +[Term] +id: GO:0035818 +name: positive regulation of urine volume by pressure natriuresis +namespace: biological_process +def: "An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf] +synonym: "diuresis resulting from pressure natriuresis" RELATED [GOC:mtg_25march11] +is_a: GO:0003095 ! pressure natriuresis +is_a: GO:0035810 ! positive regulation of urine volume + +[Term] +id: GO:0035819 +name: positive regulation of renal sodium excretion by pressure natriuresis +namespace: biological_process +def: "An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis." [GOC:mtg_25march11, GOC:yaf] +synonym: "natriuresis resulting from pressure natriuresis" RELATED [] +is_a: GO:0003095 ! pressure natriuresis +is_a: GO:0035815 ! positive regulation of renal sodium excretion + +[Term] +id: GO:0035820 +name: negative regulation of renal sodium excretion by angiotensin +namespace: biological_process +def: "The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time." [GOC:mtg_25march11, GOC:yaf] +is_a: GO:0003083 ! negative regulation of renal output by angiotensin +is_a: GO:0035814 ! negative regulation of renal sodium excretion + +[Term] +id: GO:0035821 +name: modulation of process of another organism +namespace: biological_process +def: "The process in which an organism effects a change in the structure or processes of another organism." [GOC:bf] +synonym: "modification of morphology or physiology of other organism" EXACT [] +synonym: "modulation of process of other organism" EXACT [] +synonym: "regulation of morphology of other organism" NARROW [GOC:bf] +synonym: "regulation of morphology or physiology of other organism" RELATED [GOC:bf] +synonym: "regulation of physiological process of other organism" NARROW [GOC:bf] +synonym: "regulation of physiology of other organism" NARROW [GOC:bf] +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0035822 +name: gene conversion +namespace: biological_process +def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor." [GOC:mah, PMID:17846636] +is_a: GO:0035825 ! homologous recombination + +[Term] +id: GO:0035823 +name: short tract gene conversion +namespace: biological_process +def: "A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] +is_a: GO:0035822 ! gene conversion + +[Term] +id: GO:0035824 +name: long tract gene conversion +namespace: biological_process +def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] +is_a: GO:0035822 ! gene conversion + +[Term] +id: GO:0035825 +name: homologous recombination +namespace: biological_process +def: "A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] +synonym: "chromosomal crossover" RELATED [GOC:mah, Wikipedia:Chromosomal_crossover] +synonym: "interchromosomal DNA recombination" EXACT [] +synonym: "interstrand DNA recombination" EXACT [] +synonym: "reciprocal DNA recombination" NARROW [] +xref: Wikipedia:Chromosomal_crossover +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0035826 +name: obsolete rubidium ion transport +namespace: biological_process +def: "OBSOLETE. The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "Rb+ transport" EXACT [] +synonym: "rubidium cation transport" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035827 +name: obsolete rubidium ion transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of rubidium ions (Rb+) from one side of a membrane to the other." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "Rb+ transmembrane transporter activity" EXACT [] +synonym: "rubidium cation transmembrane transporter activity" EXACT [] +synonym: "rubidium transmembrane transporter activity" RELATED [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0035828 +name: obsolete renal rubidium ion transport +namespace: biological_process +def: "OBSOLETE. The directed movement of rubidium ions (Rb+) by the kidney." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "renal Rb+ transport" EXACT [] +synonym: "renal rubidium cation transport" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035829 +name: obsolete renal rubidium ion absorption +namespace: biological_process +def: "OBSOLETE. A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "renal Rb+ absorption" EXACT [] +synonym: "renal rubidium cation absorption" EXACT [] +is_obsolete: true + +[Term] +id: GO:0035830 +name: palmatine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants." [GOC:yaf] +synonym: "palmatine metabolism" EXACT [GOC:bf] +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process + +[Term] +id: GO:0035831 +name: palmatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants." [GOC:yaf] +synonym: "palmatine anabolism" EXACT [GOC:bf] +synonym: "palmatine biosynthesis" EXACT [GOC:bf] +synonym: "palmatine formation" EXACT [GOC:bf] +synonym: "palmatine synthesis" EXACT [GOC:bf] +is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process +is_a: GO:0035830 ! palmatine metabolic process + +[Term] +id: GO:0035832 +name: berbamunine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid." [GOC:yaf] +synonym: "berbamunine metabolism" EXACT [GOC:bf] +is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process + +[Term] +id: GO:0035833 +name: berbamunine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid." [GOC:yaf] +synonym: "berbamunine anabolism" EXACT [GOC:bf] +synonym: "berbamunine biosynthesis" EXACT [GOC:bf] +synonym: "berbamunine formation" EXACT [GOC:bf] +synonym: "berbamunine synthesis" EXACT [GOC:bf] +is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process +is_a: GO:0035832 ! berbamunine metabolic process + +[Term] +id: GO:0035834 +name: indole alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] +synonym: "indole alkaloid metabolism" EXACT [GOC:bf] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:0035835 +name: indole alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton." [GOC:yaf] +synonym: "indole alkaloid anabolism" EXACT [GOC:bf] +synonym: "indole alkaloid biosynthesis" EXACT [GOC:bf] +synonym: "indole alkaloid formation" EXACT [GOC:bf] +synonym: "indole alkaloid synthesis" EXACT [GOC:bf] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0035834 ! indole alkaloid metabolic process + +[Term] +id: GO:0035836 +name: ergot alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid." [GOC:yaf] +synonym: "ergot alkaloid metabolism" EXACT [GOC:bf] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process + +[Term] +id: GO:0035837 +name: ergot alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an ergot alkaloid." [GOC:yaf] +synonym: "ergot alkaloid anabolism" EXACT [GOC:bf] +synonym: "ergot alkaloid biosynthesis" EXACT [GOC:bf] +synonym: "ergot alkaloid formation" EXACT [GOC:bf] +synonym: "ergot alkaloid synthesis" EXACT [GOC:bf] +is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process +is_a: GO:0035836 ! ergot alkaloid metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0035838 +name: growing cell tip +namespace: cellular_component +def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah] +synonym: "growing cell end" EXACT [GOC:mah] +is_a: GO:0030427 ! site of polarized growth +is_a: GO:0051286 ! cell tip + +[Term] +id: GO:0035839 +name: non-growing cell tip +namespace: cellular_component +def: "A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] +synonym: "new cell end" RELATED [GOC:mah] +synonym: "non-growing cell end" EXACT [GOC:mah] +is_a: GO:0051286 ! cell tip + +[Term] +id: GO:0035840 +name: old growing cell tip +namespace: cellular_component +def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] +synonym: "old growing cell end" EXACT [GOC:mah] +is_a: GO:0035838 ! growing cell tip + +[Term] +id: GO:0035841 +name: new growing cell tip +namespace: cellular_component +def: "A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth." [GOC:expert_jd, GOC:mah, PMID:19431238] +synonym: "new cell tip after activation of bipolar cell growth" EXACT [GOC:bf] +synonym: "post-NETO new cell end" EXACT [GOC:mah] +synonym: "post-NETO new cell tip" EXACT [GOC:mah] +synonym: "post-new end take-off new cell tip" EXACT [GOC:mah] +is_a: GO:0035838 ! growing cell tip + +[Term] +id: GO:0035842 +name: old cell tip after activation of bipolar cell growth +namespace: cellular_component +def: "A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures." [GOC:expert_jd, GOC:mah] +synonym: "post-NETO old cell end" EXACT [GOC:mah] +synonym: "post-NETO old cell tip" EXACT [GOC:mah] +synonym: "post-new end take-off old cell tip" EXACT [GOC:mah] +is_a: GO:0035840 ! old growing cell tip + +[Term] +id: GO:0035843 +name: endonuclear canal +namespace: cellular_component +def: "A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope." [GOC:bf, PMID:18359585] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0001673 ! male germ cell nucleus + +[Term] +id: GO:0035844 +name: cloaca development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates." [GOC:dgh, ISBN:0582227089] +synonym: "cloacal development" EXACT [GOC:bf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001655 ! urogenital system development +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0035845 +name: photoreceptor cell outer segment organization +namespace: biological_process +def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials." [ISBN:0824072820, PMID:14507858] +synonym: "photoreceptor cell outer segment organisation" EXACT [GOC:mah] +synonym: "photoreceptor outer segment organization" EXACT [GOC:bf] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0042461 ! photoreceptor cell development + +[Term] +id: GO:0035846 +name: oviduct epithelium development +namespace: biological_process +def: "The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct." [GOC:yaf, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube epithelium development" NARROW [GOC:yaf] +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0060066 ! oviduct development + +[Term] +id: GO:0035847 +name: uterine epithelium development +namespace: biological_process +def: "The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:bf, GOC:yaf] +synonym: "uterus epithelial development" EXACT [GOC:yaf] +is_a: GO:0035846 ! oviduct epithelium development +relationship: part_of GO:0060065 ! uterus development + +[Term] +id: GO:0035848 +name: oviduct morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:yaf, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube morphogenesis" NARROW [GOC:yaf] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0060066 ! oviduct development + +[Term] +id: GO:0035849 +name: nephric duct elongation +namespace: biological_process +def: "The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0072178 ! nephric duct morphogenesis + +[Term] +id: GO:0035850 +name: epithelial cell differentiation involved in kidney development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10, GOC:yaf, PMID:16216236] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0061005 ! cell differentiation involved in kidney development + +[Term] +id: GO:0035851 +name: Krueppel-associated box domain binding +namespace: molecular_function +def: "Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors." [InterPro:IPR001909] +synonym: "KRAB domain binding" EXACT [InterPro:IPR001909] +synonym: "Krueppel-associated box binding" EXACT [InterPro:IPR001909] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0035852 +name: horizontal cell localization +namespace: biological_process +def: "Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina." [CL:0000745, GOC:bf, GOC:yaf, PMID:18094249] +synonym: "horizontal cell localisation" EXACT [GOC:mah] +synonym: "horizontal cell positioning" EXACT [PMID:18094249] +synonym: "laminar positioning of retinal horizontal cell" EXACT [PMID:18094249] +synonym: "retinal horizontal cell positioning" EXACT [PMID:18094249] +is_a: GO:0051674 ! localization of cell +relationship: part_of GO:0010842 ! retina layer formation + +[Term] +id: GO:0035853 +name: chromosome passenger complex localization to spindle midzone +namespace: biological_process +def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:mah, GOC:vw, PMID:15296749] +synonym: "chromosomal passenger complex localization to spindle midzone" EXACT [GOC:bf] +synonym: "chromosome passenger complex localisation to spindle midzone" EXACT [GOC:bf] +synonym: "chromosome passenger complex localization to central spindle" EXACT [PMID:14528012] +synonym: "chromosome passenger complex localization to spindle equator" EXACT [GOC:bf] +synonym: "CPC complex localization to spindle midzone" EXACT [GOC:bf] +synonym: "CPC localization to spindle midzone" EXACT [GOC:bf] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0044380 ! protein localization to cytoskeleton + +[Term] +id: GO:0035854 +name: eosinophil fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin." [CL:0000771, GOC:BHF, GOC:vk] +synonym: "eosinophil cell fate commitment" EXACT [GOC:bf] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0035855 +name: megakaryocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow." [CL:0000556, GOC:BHF, GOC:vk] +synonym: "megakaryocyte cell development" EXACT [GOC:bf] +is_a: GO:0061515 ! myeloid cell development +is_a: GO:0098751 ! bone cell development +relationship: part_of GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0035857 +name: eosinophil fate specification +namespace: biological_process +def: "The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [CL:0000771, GOC:BHF, GOC:vk] +synonym: "eosinophil cell fate specification" EXACT [GOC:bf] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0035854 ! eosinophil fate commitment + +[Term] +id: GO:0035858 +name: eosinophil fate determination +namespace: biological_process +def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000771, GOC:BHF, GOC:vk] +synonym: "eosinophil cell fate determination" EXACT [GOC:bf] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0035854 ! eosinophil fate commitment + +[Term] +id: GO:0035859 +name: Seh1-associated complex +namespace: cellular_component +def: "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p." [GOC:jh, PMID:21454883, PMID:23974112] +comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. +synonym: "GATOR complex" EXACT [GOC:rb, PMID:23723238] +synonym: "SEA complex" EXACT [GOC:jh, PMID:21454883] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0035860 +name: glial cell-derived neurotrophic factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:yaf, PMID:12953054] +synonym: "GDNF receptor signaling pathway" EXACT [GOC:yaf] +synonym: "glial cell derived neurotrophic factor receptor signaling pathway" EXACT [GOC:bf] +synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:yaf] +synonym: "glial cell-derived neurotrophic factor receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0035861 +name: site of double-strand break +namespace: cellular_component +def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] +synonym: "DNA damage foci" RELATED [GOC:vw] +synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408] +synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408] +synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408] +synonym: "site of DSB" EXACT [PMID:21035408] +is_a: GO:0090734 ! site of DNA damage + +[Term] +id: GO:0035862 +name: dITP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:bf] +synonym: "2'-Deoxyinosine 5'-triphosphate metabolic process" EXACT [] +synonym: "2'-Deoxyinosine-5'-triphosphate metabolic process" EXACT [] +synonym: "deoxyinosine 5'-triphosphate metabolic process" EXACT [] +synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) metabolic process" EXACT [GOC:dgf] +synonym: "dITP metabolism" EXACT [GOC:bf] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0035863 +name: dITP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position." [GOC:dgf] +synonym: "2'-Deoxyinosine 5'-triphosphate catabolic process" EXACT [] +synonym: "2'-Deoxyinosine-5'-triphosphate catabolic process" EXACT [] +synonym: "deoxyinosine 5'-triphosphate catabolic process" EXACT [] +synonym: "deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate) catabolic process" EXACT [GOC:dgf] +synonym: "dITP breakdown" EXACT [GOC:bf] +synonym: "dITP catabolism" EXACT [GOC:bf] +synonym: "dITP degradation" EXACT [GOC:bf] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0035862 ! dITP metabolic process + +[Term] +id: GO:0035864 +name: response to potassium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] +synonym: "response to K+ ion" EXACT [GOC:bf] +synonym: "response to potassium" EXACT [GOC:bf] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0035865 +name: cellular response to potassium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:yaf] +synonym: "cellular response to K+ ion" EXACT [GOC:bf] +synonym: "cellular response to potassium" EXACT [GOC:bf] +is_a: GO:0035864 ! response to potassium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0035866 +name: alphav-beta3 integrin-PKCalpha complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha." [GOC:BHF, GOC:ebc, PMID:16014375] +synonym: "alphav-beta3 integrin-PKCa complex" EXACT [GOC:ebc] +synonym: "alphav-beta3 integrin-protein kinase C alpha complex" EXACT [GOC:bf] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0035867 +name: alphav-beta3 integrin-IGF-1-IGF1R complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits." [GOC:BHF, GOC:ebc, PMID:19578119] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0035868 +name: alphav-beta3 integrin-HMGB1 complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein." [GOC:BHF, GOC:ebc, PMID:20826760] +synonym: "alphav-beta3 integrin-high mobility group box 1 complex" EXACT [GOC:bf] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0035869 +name: ciliary transition zone +namespace: cellular_component +def: "A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm." [GOC:cilia, GOC:kmv, PMID:21422230] +comment: Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. +synonym: "cilial transition zone" EXACT [] +synonym: "cilium transition zone" EXACT [] +synonym: "connecting cilium" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0035870 +name: dITP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dITP + H2O = dIMP + diphosphate." [GOC:dgf, PMID:21548881, RHEA:28342] +synonym: "2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R03531] +synonym: "deoxyinosine triphosphate pyrophosphatase activity" EXACT [GOC:bf] +synonym: "dITP pyrophosphatase activity" EXACT [GOC:bf] +xref: EC:3.6.1.66 +xref: KEGG_REACTION:R03531 +xref: MetaCyc:RXN0-1602 +xref: Reactome:R-HSA-2509838 "ITPA hydrolyses dITP to dIMP" +xref: RHEA:28342 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0035871 +name: protein K11-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein." [GOC:sp, PMID:21596315] +synonym: "protein K11-linked deubiquitinylation" EXACT [GOC:bf] +synonym: "protein K11-linked deubiquitylation" EXACT [GOC:bf] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0035872 +name: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process." [GOC:sj, PMID:18280719, Reactome:168643] +synonym: "NLR signaling pathway" EXACT [PMID:18280719] +synonym: "NOD-like receptor signaling pathway" RELATED [Wikipedia:NOD-like_receptor] +synonym: "nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway" EXACT [PMID:18280719] +synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction" EXACT [GOC:bf] +synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway" EXACT [GOC:bf] +synonym: "nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0035873 +name: lactate transmembrane transport +namespace: biological_process +def: "The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:mcc, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "lactate membrane transport" EXACT [] +is_a: GO:0015727 ! lactate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0035874 +name: cellular response to copper ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469] +synonym: "cellular response to copper starvation" EXACT [GOC:bf] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0120126 ! response to copper ion starvation + +[Term] +id: GO:0035875 +name: maintenance of meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] +synonym: "maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] +synonym: "maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:bf] +synonym: "maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:bf] +is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion +relationship: part_of GO:0051754 ! meiotic sister chromatid cohesion, centromeric + +[Term] +id: GO:0035876 +name: maintenance of meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle." [GOC:vw, PMID:1708436] +synonym: "maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:bf] +synonym: "maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:bf] +is_a: GO:0034090 ! maintenance of meiotic sister chromatid cohesion +relationship: part_of GO:0051760 ! meiotic sister chromatid cohesion, arms + +[Term] +id: GO:0035877 +name: death effector domain binding +namespace: molecular_function +def: "Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD)." [GOC:ecd, InterPro:IPR001875] +comment: For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'. +synonym: "DED binding" EXACT [InterPro:IPR001875] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0035878 +name: nail development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it." [GOC:bf, ISBN:0323025781, UBERON:0001705, Wikipedia:Nail_(anatomy)] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060173 ! limb development + +[Term] +id: GO:0035879 +name: plasma membrane lactate transport +namespace: biological_process +def: "The directed movement of lactate across a plasma membrane." [GOC:mcc] +synonym: "lactate plasma membrane transport" EXACT [GOC:bf] +is_a: GO:0035873 ! lactate transmembrane transport + +[Term] +id: GO:0035880 +name: embryonic nail plate morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits." [GOC:BHF, GOC:vk, ISBN:0323025781, PMID:11369996, UBERON:0008198, Wikipedia:Nail_(anatomy)] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0035878 ! nail development +relationship: part_of GO:0042733 ! embryonic digit morphogenesis + +[Term] +id: GO:0035881 +name: amacrine cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons." [CL:0000561, GOC:bf] +synonym: "amacrine neuron differentiation" EXACT [CL:0000561] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0003407 ! neural retina development + +[Term] +id: GO:0035882 +name: defecation rhythm +namespace: biological_process +def: "The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated." [GOC:bf, GOC:kmv, PMID:7479775, PMID:8158250, PMID:9066270] +synonym: "defecation behavior" RELATED [PMID:7479775, PMID:9066270] +synonym: "defecation cycle" EXACT [PMID:8158250] +synonym: "defecation motor program" EXACT [GOC:kmv, PMID:9066270] +synonym: "DMP" EXACT [PMID:9066270] +is_a: GO:0007624 ! ultradian rhythm +relationship: part_of GO:0030421 ! defecation + +[Term] +id: GO:0035883 +name: enteroendocrine cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." [CL:0000164, GOC:bf] +is_a: GO:0002067 ! glandular epithelial cell differentiation + +[Term] +id: GO:0035884 +name: arabinan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues." [GOC:rs, ISBN:0198506732] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0031221 ! arabinan metabolic process + +[Term] +id: GO:0035885 +name: exochitinase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293, PMID:16298970, PMID:21390509] +xref: MetaCyc:RXN-12309 +xref: RHEA:50672 +is_a: GO:0004568 ! chitinase activity + +[Term] +id: GO:0035886 +name: vascular associated smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell." [GOC:sl, PMID:16151017, PMID:18267954] +synonym: "vascular smooth muscle cell differentiation" EXACT [] +synonym: "VSMC differentiation" EXACT [PMID:16151017] +is_a: GO:0051145 ! smooth muscle cell differentiation +relationship: part_of GO:0001944 ! vasculature development + +[Term] +id: GO:0035887 +name: aortic smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta." [GOC:sl] +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:0035888 +name: isoguanine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoguanine + H2O = xanthine + NH3." [EC:3.5.4.-, GOC:imk, PMID:21604715] +synonym: "2-hydroxyadenine deaminase activity" EXACT [PMID:14709079, PMID:8841637] +synonym: "2-oxoadenine deaminase activity" EXACT [PMID:14709079] +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0035889 +name: otolith tethering +namespace: biological_process +def: "The attachment of a developing otolith to the kinocilia of tether cells in the inner ear." [GOC:dgh, PMID:14499652] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0048840 ! otolith development + +[Term] +id: GO:0035890 +name: exit from host +namespace: biological_process +def: "The directed movement of an organism out of the body, tissues or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf] +synonym: "ejection from host" RELATED [GOC:bf] +is_a: GO:0052126 ! movement in host environment + +[Term] +id: GO:0035891 +name: exit from host cell +namespace: biological_process +def: "The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:rs, PMID:19325115] +synonym: "ejection from host cell" RELATED [PMID:19325115] +synonym: "host cell exit" EXACT [PMID:19325115] +is_a: GO:0035890 ! exit from host + +[Term] +id: GO:0035892 +name: modulation of platelet aggregation in another organism +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:bf, GOC:fj, PMID:15922770] +synonym: "modulation by organism of platelet aggregation in other organism" EXACT [GOC:bf] +synonym: "modulation of platelet aggregation in other organism" EXACT [] +synonym: "regulation of platelet aggregation in other organism" RELATED [GOC:bf] +is_a: GO:0035806 ! modulation of blood coagulation in another organism +is_a: GO:0044364 ! disruption of cells of another organism +is_a: GO:0090330 ! regulation of platelet aggregation + +[Term] +id: GO:0035893 +name: negative regulation of platelet aggregation in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism." [GOC:bf, GOC:fj, PMID:15922770] +synonym: "down-regulation of platelet aggregation in other organism" EXACT [GOC:bf] +synonym: "downregulation of platelet aggregation in other organism" EXACT [GOC:bf] +synonym: "inhibition of platelet aggregation in other organism" EXACT [GOC:bf] +synonym: "negative regulation of platelet aggregation in other organism" EXACT [] +synonym: "suppression of platelet aggregation in other organism" EXACT [GOC:bf] +is_a: GO:0035892 ! modulation of platelet aggregation in another organism +is_a: GO:0035899 ! negative regulation of blood coagulation in another organism +is_a: GO:0090331 ! negative regulation of platelet aggregation + +[Term] +id: GO:0035894 +name: positive regulation of platelet aggregation in another organism +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism." [GOC:bf, GOC:fj, PMID:11453648, PMID:18804547] +synonym: "positive regulation of platelet aggregation in other organism" EXACT [] +synonym: "up-regulation of platelet aggregation in other organism" RELATED [GOC:bf] +synonym: "upregulation of platelet aggregation in other organism" EXACT [GOC:bf] +is_a: GO:0035807 ! positive regulation of blood coagulation in another organism +is_a: GO:0035892 ! modulation of platelet aggregation in another organism +is_a: GO:1901731 ! positive regulation of platelet aggregation + +[Term] +id: GO:0035895 +name: modulation of mast cell degranulation in another organism +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [GOC:bf, GOC:fj, PMID:21549739] +synonym: "modulation of mast cell degranulation in other organism" EXACT [] +synonym: "regulation of mast cell degranulation in other organism" EXACT [GOC:bf] +is_a: GO:0035821 ! modulation of process of another organism +is_a: GO:0043304 ! regulation of mast cell degranulation + +[Term] +id: GO:0035896 +name: positive regulation of mast cell degranulation in another organism +namespace: biological_process +def: "Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism." [GOC:bf, GOC:fj] +synonym: "positive regulation of mast cell degranulation in other organism" EXACT [] +synonym: "up-regulation of mast cell degranulation in other organism" RELATED [GOC:bf] +synonym: "upregulation of mast cell degranulation in other organism" EXACT [GOC:bf] +is_a: GO:0035895 ! modulation of mast cell degranulation in another organism +is_a: GO:0043306 ! positive regulation of mast cell degranulation + +[Term] +id: GO:0035897 +name: obsolete proteolysis in other organism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds." [GOC:bf, GOC:fj, PMID:15922779] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0035898 +name: parathyroid hormone secretion +namespace: biological_process +def: "The regulated release of parathyroid hormone into the circulatory system." [GOC:cjm, PMID:12171519, PMID:21164021] +synonym: "parathormone secretion" EXACT [PR:000013429] +synonym: "parathyrin secretion" EXACT [PR:000013429] +synonym: "PTH secretion" EXACT [PMID:12171519, PR:000013429] +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0035899 +name: negative regulation of blood coagulation in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot." [GOC:fj] +synonym: "down-regulation of blood coagulation in other organism" EXACT [GOC:bf] +synonym: "downregulation of blood coagulation in other organism" EXACT [GOC:bf] +synonym: "inhibition of blood coagulation in other organism" NARROW [GOC:bf] +synonym: "negative regulation of blood clotting in other organism" EXACT [GOC:bf] +synonym: "negative regulation of blood coagulation in other organism" EXACT [] +synonym: "suppression of blood coagulation in other organism" EXACT [GOC:bf] +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:0035806 ! modulation of blood coagulation in another organism + +[Term] +id: GO:0035900 +name: response to isolation stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532] +synonym: "response to social isolation" EXACT [PMID:20203532] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0035901 +name: cellular response to isolation stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species." [GOC:bf, PMID:20203532] +synonym: "cellular response to social isolation" EXACT [PMID:20203532] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0035900 ! response to isolation stress + +[Term] +id: GO:0035902 +name: response to immobilization stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991] +synonym: "response to immobilisation stress" EXACT [GOC:bf] +synonym: "response to restraint stress" RELATED [GOC:sl] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0035903 +name: cellular response to immobilization stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile." [GOC:bf, PMID:17683801, PMID:19893991] +synonym: "cellular response to immobilisation stress" EXACT [GOC:bf] +synonym: "cellular response to restraint stress" RELATED [GOC:sl] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0035902 ! response to immobilization stress + +[Term] +id: GO:0035904 +name: aorta development +namespace: biological_process +def: "The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] +is_a: GO:0060840 ! artery development + +[Term] +id: GO:0035905 +name: ascending aorta development +namespace: biological_process +def: "The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035904 ! aorta development + +[Term] +id: GO:0035906 +name: descending aorta development +namespace: biological_process +def: "The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035904 ! aorta development + +[Term] +id: GO:0035907 +name: dorsal aorta development +namespace: biological_process +def: "The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] +is_a: GO:0035904 ! aorta development + +[Term] +id: GO:0035908 +name: ventral aorta development +namespace: biological_process +def: "The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604] +is_a: GO:0035904 ! aorta development + +[Term] +id: GO:0035909 +name: aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, MA:0000062, UBERON:0000947, Wikipedia:Aorta] +is_a: GO:0048844 ! artery morphogenesis +relationship: part_of GO:0035904 ! aorta development + +[Term] +id: GO:0035910 +name: ascending aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002570, UBERON:0001496, Wikipedia:Ascending_aorta] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035905 ! ascending aorta development +relationship: part_of GO:0035909 ! aorta morphogenesis + +[Term] +id: GO:0035911 +name: descending aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once." [GOC:bf, GOC:dgh, MA:0002571, UBERON:0001514, Wikipedia:Descending_aorta] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035906 ! descending aorta development +relationship: part_of GO:0035909 ! aorta morphogenesis + +[Term] +id: GO:0035912 +name: dorsal aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0005805, Wikipedia:Aorta, ZFA:0000014] +is_a: GO:0035909 ! aorta morphogenesis +relationship: part_of GO:0035907 ! dorsal aorta development + +[Term] +id: GO:0035913 +name: ventral aorta morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once." [GOC:bf, GOC:dgh, UBERON:0003085, Wikipedia:Aorta, ZFA:0000604] +is_a: GO:0035909 ! aorta morphogenesis +relationship: part_of GO:0035908 ! ventral aorta development + +[Term] +id: GO:0035914 +name: skeletal muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle." [CL:0000188, GOC:BHF, GOC:vk] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0035915 +name: pore formation in membrane of another organism +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism." [GOC:bf, GOC:fj, PMID:21549739] +synonym: "pore complex assembly in other organism" EXACT [] +synonym: "pore complex biogenesis in other organism" EXACT [GOC:bf] +synonym: "pore formation in membrane of other organism" EXACT [] +synonym: "pore formation in other organism" EXACT [GOC:bf] +synonym: "pore-forming toxin activity" RELATED [GOC:bf] +is_a: GO:0051673 ! membrane disruption in another organism + +[Term] +id: GO:0035916 +name: modulation of calcium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515] +synonym: "modulation of calcium channel activity in other organism" EXACT [] +is_a: GO:0044561 ! modulation of ion channel activity in another organism + +[Term] +id: GO:0035917 +name: negative regulation of calcium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism." [GOC:bf, GOC:fj, PMID:20920515] +synonym: "down-regulation of calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "downregulation of calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "inhibition of calcium channel activity in other organism" NARROW [GOC:bf] +synonym: "negative regulation of calcium channel activity in other organism" EXACT [GOC:bf] +is_a: GO:0035916 ! modulation of calcium channel activity in another organism + +[Term] +id: GO:0035918 +name: negative regulation of voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] +synonym: "down-regulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "downregulation of voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "inhibition of voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] +synonym: "negative regulation of voltage gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of voltage-gated calcium channel activity in other organism" EXACT [] +synonym: "negative regulation of voltage-sensitive calcium channel activity in other organism" EXACT [GOC:bf] +is_a: GO:0035917 ! negative regulation of calcium channel activity in another organism + +[Term] +id: GO:0035919 +name: negative regulation of low voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] +synonym: "down-regulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "downregulation of low voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "inhibition of low voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] +synonym: "negative regulation of low voltage gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of low voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of low voltage-gated calcium channel activity in other organism" EXACT [] +is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in another organism + +[Term] +id: GO:0035920 +name: negative regulation of high voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:bf, GOC:fj, ISBN:0815340729, PMID:20920515] +synonym: "down-regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "downregulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "inhibition of high voltage-gated calcium channel activity in other organism" NARROW [GOC:bf] +synonym: "negative regulation of high voltage gated calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of high voltage-dependent calcium channel activity in other organism" EXACT [GOC:bf] +synonym: "negative regulation of high voltage-gated calcium channel activity in other organism" EXACT [GOC:bf] +is_a: GO:0035918 ! negative regulation of voltage-gated calcium channel activity in another organism + +[Term] +id: GO:0035921 +name: desmosome disassembly +namespace: biological_process +def: "The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:BHF, GOC:vk, ISBN:0198506732, PMID:9182671] +synonym: "desmosome dissociation" EXACT [PMID:9182671] +is_a: GO:0002934 ! desmosome organization +is_a: GO:0150147 ! cell-cell junction disassembly + +[Term] +id: GO:0035922 +name: foramen ovale closure +namespace: biological_process +def: "The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow." [GOC:BHF, GOC:vk, PMID:19762328, UBERON:0004754, Wikipedia:Foramen_ovale_(heart)] +synonym: "foramen ovale of heart closure" EXACT [UBERON:0004754] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060411 ! cardiac septum morphogenesis + +[Term] +id: GO:0035923 +name: flurbiprofen binding +namespace: molecular_function +def: "Binding to flurbiprofen." [GOC:BHF, GOC:rl] +synonym: "2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid binding" EXACT [] +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0035924 +name: cellular response to vascular endothelial growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, PMID:18440775] +synonym: "cellular response to vascular endothelial growth factor" EXACT [GOC:rl] +synonym: "cellular response to VEGF" EXACT [GOC:rl] +synonym: "cellular response to VEGFA" NARROW [GOC:rl] +synonym: "cellular response to VEGFB" NARROW [GOC:rl] +is_a: GO:0071363 ! cellular response to growth factor stimulus + +[Term] +id: GO:0035925 +name: mRNA 3'-UTR AU-rich region binding +namespace: molecular_function +alt_id: GO:0017091 +def: "Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs." [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590] +synonym: "adenylate/uridylate-rich element binding" EXACT [] +synonym: "ARE binding" RELATED [] +synonym: "AU-rich element binding" RELATED [] +synonym: "mRNA 3'-UTR adenylate/uridylate-rich element binding" EXACT [PMID:8578590] +is_a: GO:0003730 ! mRNA 3'-UTR binding + +[Term] +id: GO:0035927 +name: RNA import into mitochondrion +namespace: biological_process +def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904] +synonym: "cytoplasmic RNA import into mitochondrion" NARROW [GOC:ans] +synonym: "nuclear-encoded RNA import into mitochondrion" NARROW [GOC:bf] +is_a: GO:0050658 ! RNA transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0035928 +name: rRNA import into mitochondrion +namespace: biological_process +def: "The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix." [GOC:ans, PMID:20691904] +synonym: "cytoplasmic rRNA import into mitochondrion" NARROW [GOC:ans] +synonym: "nuclear-encoded rRNA import into mitochondrion" NARROW [GOC:bf] +is_a: GO:0035927 ! RNA import into mitochondrion +is_a: GO:0051029 ! rRNA transport + +[Term] +id: GO:0035929 +name: steroid hormone secretion +namespace: biological_process +def: "The regulated release of any steroid that acts as a hormone into the circulatory system." [GOC:sl] +is_a: GO:0060986 ! endocrine hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035930 +name: corticosteroid hormone secretion +namespace: biological_process +def: "The regulated release of any corticosteroid hormone into the circulatory system." [GOC:sl] +synonym: "corticosteroid secretion" BROAD [GOC:bf] +is_a: GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:0035931 +name: mineralocorticoid secretion +namespace: biological_process +def: "The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism." [GOC:sl] +is_a: GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:0035932 +name: aldosterone secretion +namespace: biological_process +def: "The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney." [GOC:sl] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:0035933 +name: glucocorticoid secretion +namespace: biological_process +def: "The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood." [GOC:sl] +is_a: GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:0035934 +name: corticosterone secretion +namespace: biological_process +def: "The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands." [GOC:sl] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0035933 ! glucocorticoid secretion + +[Term] +id: GO:0035935 +name: androgen secretion +namespace: biological_process +def: "The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates." [GOC:sl] +is_a: GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:0035936 +name: testosterone secretion +namespace: biological_process +def: "The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5." [GOC:sl, PMID:12606499] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035937 +name: estrogen secretion +namespace: biological_process +def: "The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals." [GOC:sl] +synonym: "oestrogen secretion" RELATED [] +is_a: GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:0035938 +name: estradiol secretion +namespace: biological_process +def: "The regulated release of estradiol into the circulatory system." [GOC:sl, PMID:21632818] +synonym: "oestradiol secretion" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035939 +name: microsatellite binding +namespace: molecular_function +def: "Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem." [GOC:yaf, PMID:21290414, SO:0000289] +synonym: "microsatellite DNA binding" EXACT [GOC:bf] +synonym: "variable number tandem repeat binding" EXACT [PMID:21290414] +synonym: "VNTR binding" EXACT [SO:0000289] +is_a: GO:0003696 ! satellite DNA binding + +[Term] +id: GO:0035940 +name: obsolete negative regulation of peptidase activity in other organism +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism." [GOC:klp, PMID:10595640] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of peptidase activity in other organism" EXACT [GOC:bf] +synonym: "down-regulation of protease activity in other organism" NARROW [GOC:bf] +synonym: "downregulation of peptidase activity in other organism" EXACT [GOC:bf] +synonym: "inhibition of protease activity in other organism" NARROW [GOC:bf] +synonym: "negative regulation of protease activity in other organism" NARROW [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0035941 +name: androstenedione secretion +namespace: biological_process +def: "The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system." [GOC:sl] +synonym: "androst-4-ene-3,17-dione secretion" EXACT [] +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035942 +name: dehydroepiandrosterone secretion +namespace: biological_process +def: "The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system." [GOC:sl] +synonym: "3beta-hydroxyandrost-5-en-17-one secretion" EXACT [] +synonym: "dehydroisoandrosterone secretion" EXACT [] +synonym: "DHEA secretion" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035943 +name: estrone secretion +namespace: biological_process +def: "The regulated release of estrone into the circulatory system." [GOC:sl, PMID:8395854] +synonym: "3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [] +synonym: "folliculin secretion" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046879 ! hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0035944 +name: perforin production +namespace: biological_process +def: "The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0035945 +name: mitochondrial ncRNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion." [GOC:ans, PMID:19864255] +synonym: "mitochondrial aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "mitochondrial ncRNA quality control" EXACT [GOC:dgf, GOC:krc] +synonym: "mitochondrial non-coding RNA surveillance" EXACT [GOC:bf] +is_a: GO:2000827 ! mitochondrial RNA surveillance + +[Term] +id: GO:0035946 +name: mitochondrial mRNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion." [GOC:ans, PMID:19864255] +synonym: "mitochondrial aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "mitochondrial messenger RNA surveillance" EXACT [GOC:bf] +synonym: "mitochondrial mRNA quality control" EXACT [GOC:dgf, GOC:krc] +is_a: GO:2000827 ! mitochondrial RNA surveillance + +[Term] +id: GO:0035947 +name: obsolete regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of gluconeogenesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035948 +name: obsolete positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of gluconeogenesis by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of gluconeogenesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of gluconeogenesis by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of gluconeogenesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of gluconeogenesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of gluconeogenesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "regulation of glucose biosynthetic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glucose biosynthetic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035949 +name: obsolete positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17875938] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of gluconeogenesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of gluconeogenesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of gluconeogenesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of gluconeogenesis by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] +synonym: "positive regulation of gluconeogenesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthesis by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthesis by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthesis by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthesis by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of glucose biosynthetic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthetic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthetic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glucose biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035950 +name: obsolete regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of oligopeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035951 +name: obsolete positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of oligopeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of oligopeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of oligopeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of oligopeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of oligopeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of oligopeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035952 +name: obsolete negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of oligopeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of oligopeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of oligopeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of oligopeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] +synonym: "negative regulation of oligopeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035953 +name: obsolete regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:17005992] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of dipeptide transport by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035954 +name: obsolete positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of dipeptide transport by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of dipeptide transport by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of dipeptide transport by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of dipeptide transport by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of dipeptide transport by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of dipeptide transport by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035955 +name: obsolete negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:10850718, PMID:17005992, PMID:9427760] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of dipeptide transport by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of dipeptide transport by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of dipeptide transport by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of dipeptide transport by inhibition of transcription from RNA polymerase II promoter" NARROW [GOC:obol] +synonym: "negative regulation of dipeptide transport by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035956 +name: obsolete regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9342405] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GGOC:obol] +synonym: "regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035957 +name: obsolete positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of starch breakdown by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch breakdown by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch catabolic process by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch catabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch degradation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of starch degradation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035958 +name: obsolete regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of glyoxylate bypass by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of glyoxylate bypass by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "regulation of glyoxylate cycle by regulation of transcription from Pol II promoter" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035959 +name: obsolete positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11024040, PMID:17875938, PMID:19686338] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate bypass by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate bypass by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate bypass by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate bypass by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of glyoxylate cycle by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035960 +name: obsolete regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229, PMID:16055745] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of ergosterol anabolism by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of ergosterol anabolism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "regulation of ergosterol biosynthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of ergosterol biosynthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "regulation of ergosterol biosynthetic process by regulation of transcription from Pol II promoter" RELATED [GOC:obol] +synonym: "regulation of ergosterol formation by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of ergosterol formation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "regulation of ergosterol synthesis by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of ergosterol synthesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035961 +name: obsolete positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol anabolism by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol anabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol anabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol anabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol biosynthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol biosynthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by activation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by positive regulation of transcription from Pol II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by stimulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by up regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by up-regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol biosynthetic process by upregulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol formation by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol formation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol formation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol formation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol formation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol synthesis by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:obol] +synonym: "positive regulation of ergosterol synthesis by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol synthesis by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of ergosterol synthesis by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035962 +name: response to interleukin-13 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461] +synonym: "response to IL-13" EXACT [GOC:bf] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0035963 +name: cellular response to interleukin-13 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus." [GOC:sjw, PMID:20100461] +synonym: "cellular response to IL-13" EXACT [GOC:bf] +is_a: GO:0035962 ! response to interleukin-13 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0035964 +name: COPI-coated vesicle budding +namespace: biological_process +def: "The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle." [GOC:br, PMID:10052452, PMID:17041781] +synonym: "COPI vesicle budding" EXACT [PMID:17041781] +is_a: GO:0006900 ! vesicle budding from membrane +relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi + +[Term] +id: GO:0035965 +name: cardiolipin acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids." [GOC:bf, GOC:rb, PMID:19244244] +synonym: "cardiolipin acyl-chain remodelling" EXACT [GOC:bf] +synonym: "cardiolipin maturation" BROAD [GOC:rb] +synonym: "diphosphatidylglycerol remodeling" RELATED [] +is_a: GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:0035966 +name: response to topologically incorrect protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] +synonym: "response to misfolded or unfolded protein" RELATED [GOC:bf] +is_a: GO:0006950 ! response to stress +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0035967 +name: cellular response to topologically incorrect protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure." [GOC:bf] +synonym: "cellular response to misfolded or unfolded protein" RELATED [GOC:bf] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0035966 ! response to topologically incorrect protein +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0035968 +name: obsolete regulation of sterol import by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:12077145] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of sterol import by regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "regulation of sterol influx by regulation of transcription from Pol II promoter" EXACT [GOC:bf] +synonym: "regulation of sterol influx by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] +synonym: "regulation of sterol uptake by regulation of transcription from Pol II promoter" EXACT [GOC:bf] +synonym: "regulation of sterol uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0035969 +name: obsolete positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:11533229] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol import by positive regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:0035970 +name: peptidyl-threonine dephosphorylation +namespace: biological_process +def: "The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine." [GOC:bf] +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035971 +name: peptidyl-histidine dephosphorylation +namespace: biological_process +def: "The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine." [GOC:BHF, GOC:vk, PMID:12383260] +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0035973 +name: aggrephagy +namespace: biological_process +alt_id: GO:0035972 +def: "Selective degradation of protein aggregates by macroautophagy." [GOC:autophagy, GOC:kmv, PMID:18508269, PMID:25062811] +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0035974 +name: meiotic spindle pole body +namespace: cellular_component +def: "The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:vw, PMID:21775631] +is_a: GO:0005816 ! spindle pole body + +[Term] +id: GO:0035975 +name: carbamoyl phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [GOC:yaf, UniPathway:UPA00996] +synonym: "carbamoyl phosphate breakdown" EXACT [GOC:bf] +synonym: "carbamoyl phosphate catabolism" EXACT [GOC:bf] +synonym: "carbamoyl phosphate degradation" EXACT [GOC:bf] +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:0070408 ! carbamoyl phosphate metabolic process + +[Term] +id: GO:0035976 +name: transcription factor AP-1 complex +namespace: cellular_component +def: "A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes." [GOC:bf, GOC:BHF, GOC:rl, PMID:20060892, PMID:9069263, Wikipedia:AP-1_transcription_factor] +synonym: "Activating protein 1 complex" EXACT [GOC:rl] +synonym: "AP-1 complex" EXACT [GOC:rl] +synonym: "AP1 complex" EXACT [GOC:rl] +synonym: "transcription factor AP1 complex" EXACT [GOC:rl] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0035977 +name: protein deglycosylation involved in glycoprotein catabolic process +namespace: biological_process +def: "The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein." [GOC:bf, GOC:vw] +is_a: GO:0006517 ! protein deglycosylation +relationship: part_of GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0035978 +name: histone H2A-S139 phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone." [GOC:yaf, PMID:16061642] +comment: Residue 1 of histone H2AX is taken as the first residue following removal of the initiating Methionine (Met). +synonym: "histone H2A.x phosphorylation at S139" NARROW [GOC:bf, PMID:16061642] +is_a: GO:0035404 ! histone-serine phosphorylation +is_a: GO:1990164 ! histone H2A phosphorylation + +[Term] +id: GO:0035979 +name: histone kinase activity (H2A-S139 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A." [GOC:yaf, PMID:16061642] +comment: Residue 1 of histone H2A is taken as the first residue following removal of the initiating Methionine (Met). +synonym: "histone kinase activity (H2A.x-S139 specific)" NARROW [GOC:bf, PMID:16061642] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0035980 +name: obsolete invasive growth in response to nitrogen limitation +namespace: biological_process +def: "OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen." [GOC:vw] +comment: This term was made obsolete because the GO term 'pseudohyphal growth ; GO:0007124' describes growth under nitrogen-limiting conditions. +synonym: "invasive growth in response to nitrogen limitation" EXACT [] +is_obsolete: true +consider: GO:0007124 + +[Term] +id: GO:0035981 +name: tongue muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell." [CL:0002673, GOC:yaf, PMID:3393851] +is_a: GO:0098528 ! skeletal muscle fiber differentiation + +[Term] +id: GO:0035982 +name: obsolete age-dependent behavioral decline +namespace: biological_process +def: "OBSOLETE. A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:kmv, PMID:20523893] +comment: This term was made obsolete because it describes a phenotype. +synonym: "age-dependent behavioural decline" EXACT [GOC:bf] +synonym: "age-related behavioral decline" EXACT [GOC:kmv] +synonym: "behavioral aging" EXACT [GOC:kmv] +is_obsolete: true +replaced_by: GO:0090647 + +[Term] +id: GO:0035983 +name: response to trichostatin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0046677 ! response to antibiotic +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0035984 +name: cellular response to trichostatin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [GOC:yaf, PMID:20181743] +is_a: GO:0035983 ! response to trichostatin A +is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0035985 +name: senescence-associated heterochromatin focus +namespace: cellular_component +def: "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468] +synonym: "SAHF" EXACT [GOC:yaf] +synonym: "senescence-associated heterochromatin foci" EXACT [PMID:15621527, PMID:21248468] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:0035986 +name: obsolete senescence-associated heterochromatin focus assembly +namespace: biological_process +def: "OBSOLETE. The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468] +comment: This term was obsoleted because there is no evidence that this is a distinct process; this should be captured as an extension +synonym: "SAHF formation" EXACT [GOC:yaf] +synonym: "senescence-associated heterochromatin foci formation" EXACT [GOC:yaf] +synonym: "senescence-associated heterochromatin focus formation" EXACT [] +is_obsolete: true +consider: GO:0031507 + +[Term] +id: GO:0035987 +name: endodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332] +synonym: "endoderm cell differentiation" EXACT [CL:0000223] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001706 ! endoderm formation + +[Term] +id: GO:0035988 +name: chondrocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:yaf, PMID:21484705] +synonym: "cartilage cell proliferation" EXACT [CL:0000138] +synonym: "chondrocyte cell proliferation" EXACT [GOC:bf] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0035989 +name: tendon development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043] +synonym: "sinew development" RELATED [UBERON:0000043] +is_a: GO:0061448 ! connective tissue development + +[Term] +id: GO:0035990 +name: tendon cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429] +synonym: "muscle attachment cell differentiation" EXACT [CL:0000388] +synonym: "tenocyte differentiation" RELATED [CL:0000388] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0035992 ! tendon formation + +[Term] +id: GO:0035991 +name: nitric oxide sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957] +synonym: "NO sensor activity" EXACT [] +is_a: GO:0070026 ! nitric oxide binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0035992 +name: tendon formation +namespace: biological_process +def: "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035989 ! tendon development + +[Term] +id: GO:0035993 +name: deltoid tuberosity development +namespace: biological_process +def: "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060173 ! limb development +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0035994 +name: response to muscle stretch +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length." [GOC:BHF, GOC:vk, PMID:14583192] +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0035995 +name: detection of muscle stretch +namespace: biological_process +def: "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal." [PMID:14583192] +is_a: GO:0035994 ! response to muscle stretch +is_a: GO:0050982 ! detection of mechanical stimulus + +[Term] +id: GO:0035996 +name: rhabdomere microvillus +namespace: cellular_component +def: "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] +is_a: GO:0005902 ! microvillus +relationship: part_of GO:0016028 ! rhabdomere + +[Term] +id: GO:0035997 +name: rhabdomere microvillus membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998] +is_a: GO:0031528 ! microvillus membrane +relationship: part_of GO:0033583 ! rhabdomere membrane +relationship: part_of GO:0035996 ! rhabdomere microvillus + +[Term] +id: GO:0035998 +name: 7,8-dihydroneopterin 3'-triphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [GOC:yaf, UniPathway:UPA00848] +synonym: "7,8-dihydroneopterin 3'-triphosphate anabolism" EXACT [GOC:bf] +synonym: "7,8-dihydroneopterin 3'-triphosphate biosynthesis" EXACT [GOC:bf] +synonym: "7,8-dihydroneopterin 3'-triphosphate formation" EXACT [GOC:bf] +synonym: "7,8-dihydroneopterin 3'-triphosphate synthesis" EXACT [GOC:bf] +xref: UniPathway:UPA00848 +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process +is_a: GO:0051066 ! dihydrobiopterin metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0035999 +name: tetrahydrofolate interconversion +namespace: biological_process +def: "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193] +xref: MetaCyc:PWY-2201 +xref: UniPathway:UPA00193 +is_a: GO:0006730 ! one-carbon metabolic process +is_a: GO:0046653 ! tetrahydrofolate metabolic process + +[Term] +id: GO:0036000 +name: mucocyst +namespace: cellular_component +def: "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion." [GOC:mag, PMID:10723937, PMID:4629881] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0036001 +name: 'de novo' pyridoxal 5'-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components." [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY] +synonym: "'de novo' PLP biosynthesis" EXACT [MetaCyc:PYRIDOXSYN-PWY] +synonym: "'de novo' pyridoxal 5'-phosphate anabolism" EXACT [GOC:bf] +synonym: "'de novo' pyridoxal 5'-phosphate biosynthesis" EXACT [GOC:bf] +synonym: "'de novo' pyridoxal 5'-phosphate formation" EXACT [GOC:bf] +synonym: "'de novo' pyridoxal 5'-phosphate synthesis" EXACT [GOC:bf] +synonym: "'de novo' pyridoxal phosphate biosynthetic process" BROAD [GOC:bf] +xref: MetaCyc:PYRIDOXSYN-PWY +is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process + +[Term] +id: GO:0036002 +name: pre-mRNA binding +namespace: molecular_function +def: "Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120] +synonym: "protein-coding primary transcript binding" RELATED [SO:0000120] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0036003 +name: positive regulation of transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc] +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0036004 +name: GAF domain binding +namespace: molecular_function +def: "Binding to a GAF protein domain." [GOC:yaf, InterPro:IPR003018] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0036005 +name: response to macrophage colony-stimulating factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666] +synonym: "response to M-CSF" EXACT [GOC:bf, PMID:14687666] +synonym: "response to macrophage colony-stimulating factor stimulus" EXACT [GOC:dos] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0036006 +name: cellular response to macrophage colony-stimulating factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666] +synonym: "cellular response to M-CSF stimulus" EXACT [GOC:bf, PMID:14687666] +synonym: "cellular response to macrophage colony-stimulating factor" EXACT [GOC:bf] +is_a: GO:0036005 ! response to macrophage colony-stimulating factor +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0036007 +name: scintillon +namespace: cellular_component +def: "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen." [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0036008 +name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate." [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY] +xref: MetaCyc:SUCUTIL-PWY +is_a: GO:0005987 ! sucrose catabolic process +is_a: GO:0006002 ! fructose 6-phosphate metabolic process +is_a: GO:0051156 ! glucose 6-phosphate metabolic process + +[Term] +id: GO:0036009 +name: protein-glutamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine." [GOC:imk, PMID:11847124] +xref: Reactome:R-HSA-6800138 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0036010 +name: protein localization to endosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an endosome." [GOC:yaf] +synonym: "protein localisation in endosome" EXACT [GOC:bf] +synonym: "protein localization in endosome" EXACT [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0036011 +name: imaginal disc-derived leg segmentation +namespace: biological_process +def: "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf] +is_a: GO:0035285 ! appendage segmentation +relationship: part_of GO:0007480 ! imaginal disc-derived leg morphogenesis + +[Term] +id: GO:0036012 +name: cyanelle inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma." [GOC:aa, PMID:18976493] +synonym: "cyanelle inner envelope membrane" EXACT [PMID:18976493] +is_a: GO:0009528 ! plastid inner membrane +is_a: GO:0033113 ! cyanelle membrane + +[Term] +id: GO:0036013 +name: cyanelle outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope." [GOC:aa] +is_a: GO:0009527 ! plastid outer membrane +is_a: GO:0033113 ! cyanelle membrane + +[Term] +id: GO:0036014 +name: cyanelle intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer." [GOC:aa] +synonym: "cyanelle envelope lumen" EXACT [GOC:bf] +synonym: "cyanelle periplasm" EXACT [PMID:18976493] +is_a: GO:0009529 ! plastid intermembrane space +relationship: part_of GO:0033112 ! cyanelle envelope + +[Term] +id: GO:0036015 +name: response to interleukin-3 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf] +synonym: "response to IL-3" EXACT [GOC:bf] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0036016 +name: cellular response to interleukin-3 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf] +synonym: "cellular response to IL-3" EXACT [GOC:bf] +is_a: GO:0036015 ! response to interleukin-3 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0036017 +name: response to erythropoietin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0036018 +name: cellular response to erythropoietin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf] +is_a: GO:0036017 ! response to erythropoietin +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0036019 +name: endolysosome +namespace: cellular_component +def: "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991] +is_a: GO:0005764 ! lysosome +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0036020 +name: endolysosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde] +synonym: "endolysosomal membrane" EXACT [GOC:bf] +is_a: GO:0005765 ! lysosomal membrane +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0036019 ! endolysosome + +[Term] +id: GO:0036021 +name: endolysosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde] +synonym: "endolysosomal lumen" EXACT [GOC:bf] +is_a: GO:0031904 ! endosome lumen +is_a: GO:0043202 ! lysosomal lumen +relationship: part_of GO:0036019 ! endolysosome + +[Term] +id: GO:0036022 +name: limb joint morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf] +synonym: "knee morphogenesis" NARROW [GOC:bf] +synonym: "leg joint morphogenesis" NARROW [GOC:bf] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0036023 +name: embryonic skeletal limb joint morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb." [GOC:bf, Wikipedia:Joint] +is_a: GO:0036022 ! limb joint morphogenesis +is_a: GO:0060272 ! embryonic skeletal joint morphogenesis +relationship: part_of GO:0030326 ! embryonic limb morphogenesis + +[Term] +id: GO:0036024 +name: protein C inhibitor-TMPRSS7 complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7." [GOC:ans, PMID:15853774] +synonym: "PCI-TMPRSS7 complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-TMPRSS7 complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-matriptase-3 complex" EXACT [PMID:15853774, PR:000016461] +synonym: "protein C inhibitor-transmembrane protease serine 7 complex" EXACT [PR:000016461] +synonym: "serpin A5-TMPRSS7 complex" EXACT [PR:000014685] +synonym: "SERPINA5-TMPRSS7 complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036025 +name: protein C inhibitor-TMPRSS11E complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E." [GOC:ans, PMID:15328353] +synonym: "PCI-TMPRSS11E complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-TMPRSS11E complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-transmembrane protease serine 11E complex" EXACT [PR:000016451] +synonym: "serpin A5-TMPRSS11E complex" EXACT [PR:000014685] +synonym: "SERPINA5-TMPRSS11E complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036026 +name: protein C inhibitor-PLAT complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator." [GOC:ans, PMID:10340997] +synonym: "PCI-PLAT complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-PLAT complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-tissue-type plasminogen activator complex" EXACT [PMID:10340997, PR:000012825] +synonym: "protein C inhibitor-tPA complex" EXACT [PMID:10340997, PR:000012825] +synonym: "serpin A5-PLAT complex" EXACT [PR:000014685] +synonym: "SERPINA5-PLAT complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036027 +name: protein C inhibitor-PLAU complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator." [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714] +synonym: "PCI-PLAU complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-PLAU complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-U-plasminogen activator complex" EXACT [PR:000012826] +synonym: "protein C inhibitor-uPA complex" EXACT [PR:000012826] +synonym: "protein C inhibitor-urokinase-type plasminogen activator complex" EXACT [PR:000012826] +synonym: "serpin A5-PLAU complex" EXACT [PR:000014685] +synonym: "SERPINA5-PLAU complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036028 +name: protein C inhibitor-thrombin complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin." [GOC:ans, PMID:6323392] +synonym: "PCI-thrombin complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-thrombin complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-coagulation factor II complex" EXACT [PR:000007299] +synonym: "protein C inhibitor-F2 complex" EXACT [PR:000007299] +synonym: "serpin A5-thrombin complex" EXACT [PR:000014685] +synonym: "SERPINA5-thrombin complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036029 +name: protein C inhibitor-KLK3 complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen." [GOC:ans, PMID:1725227] +synonym: "PCI-KLK3 complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-KLK3 complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-kallikrein-3 complex" EXACT [PR:000003015] +synonym: "protein C inhibitor-prostate-specific antigen complex" EXACT [PR:000003015] +synonym: "serpin A5-KLK3 complex" EXACT [PR:000014685] +synonym: "SERPINA5-KLK3 complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036030 +name: protein C inhibitor-plasma kallikrein complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein." [GOC:ans, PMID:2844223, PMID:8536714] +synonym: "PCI-plasma kallikrein complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-plasma kallikrein complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-KLKB1 complex" EXACT [PR:000009420] +synonym: "serpin A5-plasma kallikrein complex" EXACT [PR:000014685] +synonym: "SERPINA5-plasma kallikrein complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0036031 +name: recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex +namespace: biological_process +def: "The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript." [GOC:bf, GOC:rb, PMID:10594013] +synonym: "capping enzyme targeting to RNA polymerase II" EXACT [PMID:10594013] +synonym: "recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex" EXACT [GOC:bf] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0006370 ! 7-methylguanosine mRNA capping + +[Term] +id: GO:0036032 +name: neural crest cell delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube." [CL:0000333, PMID:17076275] +synonym: "neural crest cell emigration" EXACT [PMID:17076275] +synonym: "neural crest cell individualization" EXACT [PMID:17076275] +synonym: "neural crest cell segregation" RELATED [PMID:17076275] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0036033 +name: mediator complex binding +namespace: molecular_function +def: "Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:18391015] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0036034 +name: mediator complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:17641689] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0036035 +name: osteoclast development +namespace: biological_process +def: "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf] +synonym: "osteoclast cell development" EXACT [GOC:bf] +is_a: GO:0061515 ! myeloid cell development +is_a: GO:0098751 ! bone cell development +relationship: part_of GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0036036 +name: cardiac neural crest cell delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube." [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374] +is_a: GO:0036032 ! neural crest cell delamination + +[Term] +id: GO:0036037 +name: CD8-positive, alpha-beta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf] +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0036038 +name: MKS complex +namespace: cellular_component +def: "A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane." [GOC:cilia, GOC:sp, PMID:21422230, PMID:21565611, PMID:21725307, PMID:22179047, PMID:25869670, PMID:26595381, PMID:26982032] +comment: Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme. +synonym: "B9 complex" NARROW [] +synonym: "MKS module" EXACT [] +synonym: "TCTN-B9D complex" BROAD [] +synonym: "tectonic complex" NARROW [] +synonym: "tectonic-like complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0035869 ! ciliary transition zone + +[Term] +id: GO:0036039 +name: curcumin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the polyphenol, curcumin." [PMID:21467222] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolic process" EXACT [GOC:obol] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione metabolism" EXACT [GOC:obol] +synonym: "curcumin metabolism" EXACT [GOC:obol] +synonym: "diferuloylmethane metabolic process" EXACT [GOC:obol] +synonym: "diferuloylmethane metabolism" EXACT [GOC:obol] +synonym: "turmeric yellow metabolic process" EXACT [GOC:obol] +synonym: "turmeric yellow metabolism" EXACT [GOC:obol] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0036040 +name: curcumin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin." [PMID:21467222] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione breakdown" EXACT [GOC:obol] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolic process" EXACT [GOC:obol] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione catabolism" EXACT [GOC:obol] +synonym: "(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione degradation" EXACT [GOC:obol] +synonym: "curcumin breakdown" EXACT [GOC:obol] +synonym: "curcumin catabolism" EXACT [GOC:obol] +synonym: "curcumin degradation" EXACT [GOC:obol] +synonym: "diferuloylmethane breakdown" EXACT [GOC:obol] +synonym: "diferuloylmethane catabolic process" EXACT [GOC:obol] +synonym: "diferuloylmethane catabolism" EXACT [GOC:obol] +synonym: "diferuloylmethane degradation" EXACT [GOC:obol] +synonym: "turmeric yellow breakdown" EXACT [GOC:obol] +synonym: "turmeric yellow catabolic process" EXACT [GOC:obol] +synonym: "turmeric yellow catabolism" EXACT [GOC:obol] +synonym: "turmeric yellow degradation" EXACT [GOC:obol] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0036039 ! curcumin metabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0036041 +name: long-chain fatty acid binding +namespace: molecular_function +def: "Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:pm, PMID:12641450] +synonym: "long chain fatty acid binding" EXACT [PMID:12641450] +is_a: GO:0005504 ! fatty acid binding + +[Term] +id: GO:0036042 +name: long-chain fatty acyl-CoA binding +namespace: molecular_function +def: "Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [GOC:krc, GOC:pm] +synonym: "long-chain fatty acyl-coenyme A binding" EXACT [] +is_a: GO:0000062 ! fatty-acyl-CoA binding + +[Term] +id: GO:0036043 +name: obsolete microspike +namespace: cellular_component +def: "OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735] +comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044393. +synonym: "microspike" EXACT [] +is_obsolete: true +replaced_by: GO:0044393 + +[Term] +id: GO:0036044 +name: obsolete protein malonylation +namespace: biological_process +def: "OBSOLETE. The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp] +comment: This term was made obsolete because it accidentally shared the same ID as negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway by negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity. New id is GO:0044394. +synonym: "protein malonylation" EXACT [] +is_obsolete: true +replaced_by: GO:0044394 + +[Term] +id: GO:0036045 +name: obsolete peptidyl-lysine malonylation +namespace: biological_process +def: "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568] +comment: This term was made obsolete because it accidentally reused an exisiting id. See replacement term GO:0044392. +synonym: "lysine malonylation" EXACT [PMID:21908771] +synonym: "peptidyl-lysine malonylation" EXACT [] +is_obsolete: true +replaced_by: GO:0044392 + +[Term] +id: GO:0036046 +name: protein demalonylation +namespace: biological_process +def: "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide." [GOC:sp, PMID:22076378] +is_a: GO:0035601 ! protein deacylation + +[Term] +id: GO:0036047 +name: peptidyl-lysine demalonylation +namespace: biological_process +def: "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0036046 ! protein demalonylation + +[Term] +id: GO:0036048 +name: protein desuccinylation +namespace: biological_process +def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:sp, PMID:22076378] +is_a: GO:0035601 ! protein deacylation + +[Term] +id: GO:0036049 +name: peptidyl-lysine desuccinylation +namespace: biological_process +def: "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0036048 ! protein desuccinylation + +[Term] +id: GO:0036050 +name: peptidyl-lysine succinylation +namespace: biological_process +def: "The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545] +xref: RESID:AA0545 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018335 ! protein succinylation + +[Term] +id: GO:0036051 +name: protein localization to trailing edge +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement." [GOC:pf, GOC:pg] +synonym: "protein localisation to trailing edge" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0036052 +name: protein localization to uropod +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell." [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750] +synonym: "protein localisation to uropod" EXACT [GOC:mah] +is_a: GO:0036051 ! protein localization to trailing edge + +[Term] +id: GO:0036053 +name: glomerular endothelium fenestra +namespace: cellular_component +def: "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259] +synonym: "GEnC fenestration" EXACT [PMID:19129259] +synonym: "glomerular endothelial cell fenestration" EXACT [PMID:19129259] +is_a: GO:0046930 ! pore complex + +[Term] +id: GO:0036054 +name: protein-malonyllysine demalonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378] +synonym: "peptidyl-malonyllysine demalonylase activity" EXACT [] +synonym: "protein lysine demalonylation activity" EXACT [PMID:21908771] +synonym: "protein malonyl lysine demalonylation activity" EXACT [GOC:bf] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0036055 +name: protein-succinyllysine desuccinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:22076378] +comment: This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. +synonym: "peptidyl-succinyllysine desuccinylase activity" EXACT [] +synonym: "succinyl lysine desuccinylase activity" BROAD [GOC:bf] +synonym: "succinyllysine desuccinylase activity" BROAD [] +xref: RHEA:47668 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0036056 +name: filtration diaphragm +namespace: cellular_component +def: "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0036057 +name: slit diaphragm +namespace: cellular_component +def: "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094] +is_a: GO:0036056 ! filtration diaphragm + +[Term] +id: GO:0036058 +name: filtration diaphragm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929] +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0036059 +name: nephrocyte diaphragm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] +is_a: GO:0034333 ! adherens junction assembly +is_a: GO:0036058 ! filtration diaphragm assembly + +[Term] +id: GO:0036060 +name: slit diaphragm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639] +is_a: GO:0036058 ! filtration diaphragm assembly + +[Term] +id: GO:0036061 +name: muscle cell chemotaxis toward tendon cell +namespace: biological_process +def: "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells." [GOC:sart, PMID:19793885] +synonym: "muscle cell attraction" RELATED [GOC:bf] +synonym: "muscle cell chemotaxis towards tendon cell" EXACT [GOC:bf, GOC:sart] +is_a: GO:0014812 ! muscle cell migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0036062 +name: presynaptic periactive zone +namespace: cellular_component +def: "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406] +synonym: "periactive zone" EXACT [PMID:10976048, PMID:18439406] +synonym: "pre-synaptic periactive zone" EXACT [] +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0042734 ! presynaptic membrane + +[Term] +id: GO:0036063 +name: acroblast +namespace: cellular_component +def: "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220] +comment: See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'. +synonym: "spermatid acroblast" EXACT [GOC:bf] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0036064 +name: ciliary basal body +namespace: cellular_component +alt_id: GO:0005932 +def: "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193] +comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. +synonym: "basal body" BROAD [] +synonym: "cilial basal body" EXACT [] +synonym: "cilium basal body" EXACT [GOC:bf] +synonym: "kinetosome" EXACT [PMID:11125699] +synonym: "microtubule basal body" EXACT [] +xref: NIF_Subcellular:sao11978067 +is_a: GO:0005815 ! microtubule organizing center +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0036065 +name: fucosylation +namespace: biological_process +def: "The covalent attachment of a fucosyl group to an acceptor molecule." [GOC:sart, PMID:19948734] +is_a: GO:0070085 ! glycosylation + +[Term] +id: GO:0036066 +name: protein O-linked fucosylation +namespace: biological_process +def: "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734] +is_a: GO:0006493 ! protein O-linked glycosylation +is_a: GO:0036065 ! fucosylation + +[Term] +id: GO:0036067 +name: light-dependent chlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light." [GOC:yaf, PMID:12242396] +synonym: "light dependent chlorophyll biosynthetic process" EXACT [GOC:yaf] +synonym: "light-dependent chlorophyll anabolism" EXACT [GOC:bf] +synonym: "light-dependent chlorophyll biosynthesis" EXACT [GOC:bf] +synonym: "light-dependent chlorophyll formation" EXACT [GOC:bf] +synonym: "light-dependent chlorophyll synthesis" EXACT [GOC:bf] +is_a: GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:0036068 +name: light-independent chlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light." [GOC:yaf, PMID:12242396, UniPathway:UPA00670] +synonym: "light independent chlorophyll biosynthetic process" EXACT [GOC:yaf] +synonym: "light-independent chlorophyll anabolism" EXACT [GOC:bf] +synonym: "light-independent chlorophyll biosynthesis" EXACT [GOC:bf] +synonym: "light-independent chlorophyll formation" EXACT [GOC:bf] +synonym: "light-independent chlorophyll synthesis" EXACT [GOC:bf] +is_a: GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:0036069 +name: light-dependent bacteriochlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396] +synonym: "light dependent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf] +synonym: "light-dependent bacteriochlorophyll anabolism" EXACT [GOC:bf] +synonym: "light-dependent bacteriochlorophyll biosynthesis" EXACT [GOC:bf] +synonym: "light-dependent bacteriochlorophyll formation" EXACT [GOC:bf] +synonym: "light-dependent bacteriochlorophyll synthesis" EXACT [GOC:bf] +is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process +is_a: GO:0036067 ! light-dependent chlorophyll biosynthetic process + +[Term] +id: GO:0036070 +name: light-independent bacteriochlorophyll biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396, UniPathway:UPA00671] +synonym: "light independent bacteriochlorophyll biosynthetic process" EXACT [GOC:bf] +synonym: "light-independent bacteriochlorophyll anabolism" EXACT [GOC:bf] +synonym: "light-independent bacteriochlorophyll biosynthesis" EXACT [GOC:bf] +synonym: "light-independent bacteriochlorophyll formation" EXACT [GOC:bf] +synonym: "light-independent bacteriochlorophyll synthesis" EXACT [GOC:bf] +is_a: GO:0030494 ! bacteriochlorophyll biosynthetic process +is_a: GO:0036068 ! light-independent chlorophyll biosynthetic process + +[Term] +id: GO:0036071 +name: N-glycan fucosylation +namespace: biological_process +def: "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [GOC:sart, PMID:19948734] +synonym: "glycoprotein fucosylation" RELATED [GOC:bf] +is_a: GO:0036065 ! fucosylation + +[Term] +id: GO:0036072 +name: direct ossification +namespace: biological_process +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034] +is_a: GO:0001503 ! ossification + +[Term] +id: GO:0036073 +name: perichondral ossification +namespace: biological_process +def: "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [GO_REF:0000034] +is_a: GO:0001957 ! intramembranous ossification + +[Term] +id: GO:0036074 +name: metaplastic ossification +namespace: biological_process +def: "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division." [GO_REF:0000034] +comment: Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. +synonym: "metaplasia" RELATED [GO_REF:0000034] +is_a: GO:0036072 ! direct ossification + +[Term] +id: GO:0036075 +name: replacement ossification +namespace: biological_process +def: "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034] +synonym: "indirect ossification" EXACT [GO_REF:0000034] +is_a: GO:0001503 ! ossification + +[Term] +id: GO:0036076 +name: ligamentous ossification +namespace: biological_process +def: "Ossification wherein bone tissue forms within ligamentous tissue." [GO_REF:0000034] +comment: Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. +is_a: GO:0001503 ! ossification + +[Term] +id: GO:0036077 +name: intratendonous ossification +namespace: biological_process +def: "Ossification wherein bone tissue forms within tendonous tissue." [GO_REF:0000034] +comment: Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. +is_a: GO:0001503 ! ossification + +[Term] +id: GO:0036078 +name: minus-end specific microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528] +is_a: GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0036080 +name: purine nucleotide-sugar transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734] +is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity + +[Term] +id: GO:0036081 +name: extracellular ammonia-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] +synonym: "ionotropic ammonia receptor activity" RELATED [PMID:19135896] +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0036082 +name: extracellular phenylacetaldehyde-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896] +synonym: "ionotropic phenylacetaldehyde receptor activity" RELATED [PMID:19135896] +is_a: GO:0005230 ! extracellular ligand-gated ion channel activity + +[Term] +id: GO:0036083 +name: obsolete positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9927444] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0036084 +name: GDP-fucose import into endoplasmic reticulum lumen +namespace: biological_process +def: "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] +synonym: "GDP-fucose import into endoplasmic reticulum" EXACT [GOC:bf] +synonym: "GDP-fucose transport across endoplasmic reticulum membrane" EXACT [GOC:bf] +synonym: "GDP-fucose transport into endoplasmic reticulum lumen" EXACT [GOC:sart] +is_a: GO:0015783 ! GDP-fucose transmembrane transport +is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport + +[Term] +id: GO:0036085 +name: GDP-fucose import into Golgi lumen +namespace: biological_process +def: "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237] +synonym: "GDP-fucose import into Golgi" EXACT [GOC:bf] +synonym: "GDP-fucose transport across Golgi membrane" EXACT [GOC:bf] +synonym: "GDP-fucose transport into Golgi lumen" EXACT [GOC:sart] +is_a: GO:0015783 ! GDP-fucose transmembrane transport + +[Term] +id: GO:0036086 +name: positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:cjk] +synonym: "positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:bf] +is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0036087 +name: glutathione synthase complex +namespace: cellular_component +def: "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer." [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212] +synonym: "glutathione synthetase complex" EXACT [PMID:12734194, PMID:14990577, PMID:1958212] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0036088 +name: D-serine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [GOC:imk] +synonym: "D-serine breakdown" EXACT [GOC:bf] +synonym: "D-serine catabolism" EXACT [GOC:bf] +synonym: "D-serine degradation" EXACT [GOC:bf] +is_a: GO:0009071 ! serine family amino acid catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0070178 ! D-serine metabolic process + +[Term] +id: GO:0036089 +name: cleavage furrow formation +namespace: biological_process +def: "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590] +comment: Consider also annotating to 'establishment of contractile ring localization involved in cell cycle cytokinesis ; GO:0032188'. +synonym: "cleavage furrow positioning" NARROW [PMID:14757750] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0099024 ! plasma membrane invagination +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0036090 +name: cleavage furrow ingression +namespace: biological_process +def: "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468] +comment: Consider also annotating to 'contractile ring contraction involved in cell cycle cytokinesis ; GO:0000916'. +synonym: "cleavage furrow contraction" EXACT [PMID:3413069] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0099024 ! plasma membrane invagination +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0036091 +name: positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:rn, PMID:14978214, PMID:18439143] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus + +[Term] +id: GO:0036092 +name: phosphatidylinositol-3-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [GOC:al, GOC:vw] +synonym: "phosphatidylinositol-3-phosphate anabolism" EXACT [GOC:bf] +synonym: "phosphatidylinositol-3-phosphate biosynthesis" EXACT [GOC:bf] +synonym: "phosphatidylinositol-3-phosphate formation" EXACT [GOC:bf] +synonym: "phosphatidylinositol-3-phosphate synthesis" EXACT [GOC:bf] +synonym: "PI(3)P biosynthesis" EXACT [] +synonym: "PtdIns3P biosynthesis" EXACT [] +is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process + +[Term] +id: GO:0036093 +name: germ cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv] +is_a: GO:0008283 ! cell population proliferation +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0036094 +name: small molecule binding +namespace: molecular_function +def: "Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] +comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. +subset: goslim_agr +subset: goslim_flybase_ribbon +is_a: GO:0005488 ! binding + +[Term] +id: GO:0036095 +name: obsolete positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:jh, PMID:14668363] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "transcriptional activation of genes involved in invasive growth" RELATED [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0036096 +name: obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing +namespace: molecular_function +def: "OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292] +comment: This term was made obsolete because it is not real a process, and was created accidentally. +synonym: "3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing" EXACT [] +synonym: "exonucleolytic trimming to generate 3' end of miRNA from pre-miRNA" RELATED [GOC:sart] +is_obsolete: true + +[Term] +id: GO:0036097 +name: obsolete pre-miRNA 3'-end processing +namespace: biological_process +def: "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292] +comment: This term was made obsolete because it is not real a process, and was created accidentally. +synonym: "microRNA 3'-end processing" BROAD [PMID:22055292] +synonym: "miRNA 3'-end processing" BROAD [PMID:22055292] +synonym: "pre-miRNA 3'-end processing" EXACT [] +is_obsolete: true + +[Term] +id: GO:0036098 +name: male germ-line stem cell population maintenance +namespace: biological_process +def: "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937] +is_a: GO:0030718 ! germ-line stem cell population maintenance + +[Term] +id: GO:0036099 +name: female germ-line stem cell population maintenance +namespace: biological_process +def: "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart] +is_a: GO:0030718 ! germ-line stem cell population maintenance + +[Term] +id: GO:0036100 +name: leukotriene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:yaf] +synonym: "leukotriene breakdown" EXACT [GOC:bf] +synonym: "leukotriene catabolism" EXACT [GOC:bf] +synonym: "leukotriene degradation" EXACT [GOC:bf] +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0036101 +name: leukotriene B4 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:yaf, PMID:9799565, UniPathway:UPA00883] +synonym: "leukotriene B4 breakdown" EXACT [GOC:bf] +synonym: "leukotriene B4 catabolism" EXACT [GOC:bf] +synonym: "leukotriene B4 degradation" EXACT [GOC:bf] +synonym: "LTB4 catabolism" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0036100 ! leukotriene catabolic process +is_a: GO:0036102 ! leukotriene B4 metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901523 ! icosanoid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0036102 +name: leukotriene B4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:bf] +synonym: "LTB4 metabolism" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0036103 +name: Kdo2-lipid A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:bf] +synonym: "Kdo2-lipid A metabolism" EXACT [GOC:bf] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:1901269 ! lipooligosaccharide metabolic process + +[Term] +id: GO:0036104 +name: Kdo2-lipid A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:yaf, UniPathway:UPA00360] +synonym: "di[3-deoxy-D-manno-octulosonyl]-lipid A biosynthesis" EXACT [UniPathway:UPA00360] +synonym: "KDO(2)-lipid A biosynthesis" EXACT [UniPathway:UPA00360] +synonym: "Kdo2-lipid A anabolism" EXACT [GOC:bf] +synonym: "Kdo2-lipid A biosynthesis" EXACT [GOC:bf] +synonym: "Kdo2-lipid A formation" EXACT [GOC:bf] +synonym: "Kdo2-lipid A synthesis" EXACT [GOC:bf] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0036103 ! Kdo2-lipid A metabolic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:1901271 ! lipooligosaccharide biosynthetic process + +[Term] +id: GO:0036105 +name: peroxisome membrane class-1 targeting sequence binding +namespace: molecular_function +def: "Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner." [GOC:pm, PMID:14709540, PMID:17020786] +comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. +synonym: "class 1 mPTS binding" EXACT [PMID:14709540] +synonym: "PEX19-dependent mPTS binding" RELATED [PMID:14709540] +is_a: GO:0033328 ! peroxisome membrane targeting sequence binding + +[Term] +id: GO:0036106 +name: peroxisome membrane class-2 targeting sequence binding +namespace: molecular_function +def: "Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner." [GOC:pm, PMID:14709540, PMID:17020786] +comment: Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. +synonym: "class 2 mPTS binding" EXACT [PMID:14709540] +synonym: "PEX19-independent mPTS binding" RELATED [PMID:14709540] +is_a: GO:0033328 ! peroxisome membrane targeting sequence binding + +[Term] +id: GO:0036107 +name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [PMID:15695810] +synonym: "4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate metabolic process" EXACT [] +synonym: "undecaprenyl phosphate alpha-L-Ara4N metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0036108 +name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [GOC:yaf, PMID:15695810, UniPathway:UPA00036] +synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate anabolism" EXACT [GOC:bf] +synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthesis" EXACT [GOC:bf] +synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate formation" EXACT [GOC:bf] +synonym: "4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate synthesis" EXACT [GOC:bf] +synonym: "undecaprenyl phosphate alpha-L-Ara4N biosynthesis" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0036107 ! 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process + +[Term] +id: GO:0036109 +name: alpha-linolenic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [PMID:15538555] +synonym: "ALA metabolism" EXACT [CHEBI:27432] +synonym: "alpha-linolenic acid metabolism" EXACT [GOC:bf] +xref: Wikipedia:Linoleic_acid +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0036110 +name: cellular response to inositol starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol." [GOC:al, PMID:19606215] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0036111 +name: very long-chain fatty-acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] +synonym: "very long-chain fatty acyl CoA metabolic process" EXACT [GOC:bf] +synonym: "very long-chain fatty acyl-CoA metabolism" EXACT [GOC:bf] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:0036112 +name: medium-chain fatty-acyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:pm] +synonym: "medium-chain fatty acyl CoA metabolic process" EXACT [GOC:bf] +synonym: "medium-chain fatty acyl-CoA metabolism" EXACT [GOC:bf] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:0036113 +name: very long-chain fatty-acyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [GOC:pm] +synonym: "very long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] +synonym: "very long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] +synonym: "very long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] +is_a: GO:0036111 ! very long-chain fatty-acyl-CoA metabolic process +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process + +[Term] +id: GO:0036114 +name: medium-chain fatty-acyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [GOC:pm] +synonym: "medium-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] +synonym: "medium-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] +synonym: "medium-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] +is_a: GO:0036112 ! medium-chain fatty-acyl-CoA metabolic process +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process + +[Term] +id: GO:0036115 +name: fatty-acyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [PMID:10578051] +synonym: "fatty-acyl-CoA breakdown" EXACT [GOC:bf] +synonym: "fatty-acyl-CoA catabolism" EXACT [GOC:bf] +synonym: "fatty-acyl-CoA degradation" EXACT [GOC:bf] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901569 ! fatty acid derivative catabolic process + +[Term] +id: GO:0036116 +name: long-chain fatty-acyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:pm] +synonym: "long-chain fatty-acyl-CoA breakdown" EXACT [GOC:bf] +synonym: "long-chain fatty-acyl-CoA catabolism" EXACT [GOC:bf] +synonym: "long-chain fatty-acyl-CoA degradation" EXACT [GOC:bf] +is_a: GO:0035336 ! long-chain fatty-acyl-CoA metabolic process +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process + +[Term] +id: GO:0036117 +name: hyaluranon cable +namespace: cellular_component +def: "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089] +synonym: "HA cable" EXACT [PMID:16900089] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0036118 +name: hyaluranon cable assembly +namespace: biological_process +def: "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089] +synonym: "HA cable assembly" EXACT [PMID:16900089] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0036119 +name: response to platelet-derived growth factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf] +synonym: "response to PDGF stimulus" EXACT [GOC:bf] +synonym: "response to platelet-derived growth factor stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0036120 +name: cellular response to platelet-derived growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf] +synonym: "cellular response to PDGF stimulus" EXACT [GOC:bf] +is_a: GO:0036119 ! response to platelet-derived growth factor +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus + +[Term] +id: GO:0036121 +name: double-stranded DNA helicase activity +namespace: molecular_function +alt_id: GO:0033676 +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix." [GOC:kmv] +synonym: "double-stranded DNA-dependent ATP-dependent DNA helicase activity" EXACT [] +synonym: "double-stranded DNA-dependent ATPase activity" EXACT [] +synonym: "dsDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:kmv] +synonym: "dsDNA-dependent ATPase activity" EXACT [] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0036122 +name: BMP binding +namespace: molecular_function +def: "Binding to a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951] +synonym: "bone morphogenetic protein binding" EXACT [GOC:bf] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0036123 +name: histone H3-K9 dimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw] +synonym: "histone H3 K9 dimethylation" EXACT [] +synonym: "histone lysine H3 K9 dimethylation" EXACT [] +is_a: GO:0018027 ! peptidyl-lysine dimethylation +is_a: GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0036124 +name: histone H3-K9 trimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw] +is_a: GO:0018023 ! peptidyl-lysine trimethylation +is_a: GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0036125 +name: fatty acid beta-oxidation multienzyme complex +namespace: cellular_component +def: "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743] +comment: For fatty acid beta-oxidation multienzyme complexes located in the mitochondrial matrix, consider instead the term 'mitochondrial fatty acid beta-oxidation multienzyme complex ; GO:0016507'. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0036126 +name: sperm flagellum +namespace: cellular_component +def: "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is always 'flagellum', hence the primary term name, but the cilium parentage is deliberate. +synonym: "sperm cilium" EXACT [] +synonym: "sperm tail" EXACT [GOC:sart] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0036127 +name: 3-sulfino-L-alanine binding +namespace: molecular_function +def: "Binding to 3-sulfino-L-alanine (cysteine sulfinate)." [GOC:al, PMID:8346915] +synonym: "cysteine sulfinate binding" EXACT [GOC:al] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0072341 ! modified amino acid binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0036128 +name: CatSper complex +namespace: cellular_component +def: "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039] +synonym: "CATSPER channel" EXACT [PMID:21224844] +synonym: "CatSper channel complex" EXACT [PMID:17478420] +is_a: GO:0005891 ! voltage-gated calcium channel complex + +[Term] +id: GO:0036129 +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:al] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0000122 + +[Term] +id: GO:0036130 +name: prostaglandin H2 endoperoxidase reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)." [GOC:mw, KEGG_REACTION:R02264, PMID:10622721, PMID:14979715, PMID:16475787] +synonym: "PGH2 9,11-endoperoxidase" EXACT [PMID:12664595] +synonym: "PGH2 9-,11-endoperoxide reductase" EXACT [PMID:12432932] +xref: KEGG_REACTION:R02264 +xref: Reactome:R-HSA-2161549 "PGH2 is reduced to PGF2a by AKR1C3" +xref: RHEA:45312 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036131 +name: prostaglandin D2 11-ketoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+." [EC:1.1.1.188, GOC:mw, KEGG_REACTION:R02799, PMID:1504718, PMID:3862115] +synonym: "PGD2 11-ketoreductase" EXACT [PMID:14996743] +synonym: "prostaglandin 11-keto reductase" EXACT [PMID:7248318] +xref: EC:1.1.1.188 +xref: KEGG_REACTION:R02799 +xref: Reactome:R-HSA-2161614 "PGD2 is reduced to 11-epi-PGF2a by AKRIC3" +xref: RHEA:45316 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036132 +name: 13-prostaglandin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG_REACTION:R04556, KEGG_REACTION:R04557, PMID:17449869] +comment: Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'. +synonym: "15-ketoprostaglandin delta13-reductase activity" RELATED [EC:1.3.1.48] +synonym: "15-oxo-delta13-prostaglandin reductase activity" RELATED [EC:1.3.1.48] +synonym: "15-oxoprostaglandin 13-reductase activity" EXACT [] +synonym: "delta13-15-ketoprostaglandin reductase activity" RELATED [EC:1.3.1.48] +synonym: "prostaglandin 13-reductase activity" RELATED [EC:1.3.1.48] +synonym: "prostaglandin delta13-reductase activity" RELATED [EC:1.3.1.48] +xref: EC:1.3.1.48 +xref: KEGG_REACTION:R04556 +xref: KEGG_REACTION:R04557 +xref: Reactome:R-HSA-2161692 "15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036133 +name: 11-hydroxythromboxane B2 dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+." [GOC:mw, KEGG_REACTION:R05060, PMID:3461463, PMID:3823488, PMID:8200461] +comment: Note that the KEGG_REACTION:R05060 reaction does not stipulate the acceptor group, and is therefore slightly more general than the activity described by GO:0036133. +synonym: "NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity" EXACT [PMID:1632314] +xref: KEGG_REACTION:R05060 +xref: Reactome:R-HSA-2161732 "TXB2 is converted to 11dh-TXB2 by TXDH" +xref: RHEA:52312 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036134 +name: 12-hydroxyheptadecatrienoic acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515] +synonym: "prostaglandin H2 degradation activity" RELATED [GOC:mw] +xref: Reactome:R-HSA-2161613 "PGH2 is degraded to 12S-HHT and MDA by TBXAS1" +xref: RHEA:48644 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036135 +name: Schwann cell migration +namespace: biological_process +def: "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function." [CL:0002573, PMID:20335460] +is_a: GO:0008347 ! glial cell migration + +[Term] +id: GO:0036136 +name: kynurenine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate." [EC:2.6.1.-, GOC:pde, PMID:15606768, PMID:4149765] +synonym: "L-kynurenine-oxaloacetate transaminase activity" EXACT [GOC:bf] +is_a: GO:0036137 ! kynurenine aminotransferase activity + +[Term] +id: GO:0036137 +name: kynurenine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid." [EC:2.6.1.-, GOC:pde] +synonym: "kynurenine-oxo-acid transaminase activity" NARROW [GOC:bf] +synonym: "L-kynurenine transaminase activity" EXACT [GOC:bf] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0036138 +name: peptidyl-histidine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine." [GOC:reh, PMID:21251231] +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0036139 +name: peptidyl-histidine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2." [GOC:reh, PMID:21251231] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0036140 +name: peptidyl-asparagine 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0036141 +name: L-phenylalanine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate." [GOC:pde, PMID:15606768] +synonym: "L-phenylalanine:oxaloacetate transaminase activity" EXACT [GOC:bf] +is_a: GO:0070546 ! L-phenylalanine aminotransferase activity + +[Term] +id: GO:0036143 +name: kringle domain binding +namespace: molecular_function +def: "Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, Wikipedia:Kringle_domain] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0036145 +name: dendritic cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316] +synonym: "DC homeostasis" RELATED [PMID:19176316] +is_a: GO:0001776 ! leukocyte homeostasis + +[Term] +id: GO:0036146 +name: cellular response to mycotoxin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:di, PMID:20548963] +is_a: GO:0010046 ! response to mycotoxin +is_a: GO:0097237 ! cellular response to toxic substance + +[Term] +id: GO:0036147 +name: rumination +namespace: biological_process +def: "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again." [GOC:maf, Wikipedia:Rumination] +synonym: "digestive rumination" EXACT [Wikipedia:Rumination] +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0036148 +name: phosphatidylglycerol acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15485873, PMID:18458083] +is_a: GO:0046471 ! phosphatidylglycerol metabolic process + +[Term] +id: GO:0036149 +name: phosphatidylinositol acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [GOC:mw, PMID:18094042, PMID:18772128] +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:0036150 +name: phosphatidylserine acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083] +synonym: "phosphatidyl-L-serine acyl-chain remodeling" NARROW [] +is_a: GO:0006658 ! phosphatidylserine metabolic process + +[Term] +id: GO:0036151 +name: phosphatidylcholine acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18195019, PMID:18458083] +is_a: GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0036152 +name: phosphatidylethanolamine acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains." [GOC:mw, PMID:18287005, PMID:18458083] +is_a: GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0036153 +name: triglyceride acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] +synonym: "triacylglycerol acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00422] +is_a: GO:0006641 ! triglyceride metabolic process +is_a: GO:0036155 ! acylglycerol acyl-chain remodeling + +[Term] +id: GO:0036154 +name: diacylglycerol acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] +synonym: "diglyceride acyl-chain remodeling" EXACT [GOC:mw, KEGG:C00165] +is_a: GO:0036155 ! acylglycerol acyl-chain remodeling +is_a: GO:0046339 ! diacylglycerol metabolic process + +[Term] +id: GO:0036155 +name: acylglycerol acyl-chain remodeling +namespace: biological_process +def: "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains." [GOC:mw, PMID:15364929] +synonym: "glyceride acyl-chain remodeling" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0036156 +name: inner dynein arm +namespace: cellular_component +def: "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092] +synonym: "inner dynein arm complex" EXACT [] +is_a: GO:0005858 ! axonemal dynein complex + +[Term] +id: GO:0036157 +name: outer dynein arm +namespace: cellular_component +def: "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174] +synonym: "outer dynein arm complex" EXACT [] +is_a: GO:0005858 ! axonemal dynein complex + +[Term] +id: GO:0036158 +name: outer dynein arm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] +synonym: "ODA assembly" EXACT [PMID:19944400] +is_a: GO:0070286 ! axonemal dynein complex assembly + +[Term] +id: GO:0036159 +name: inner dynein arm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400] +synonym: "IDA assembly" EXACT [PMID:19944400] +is_a: GO:0070286 ! axonemal dynein complex assembly + +[Term] +id: GO:0036160 +name: melanocyte-stimulating hormone secretion +namespace: biological_process +def: "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone] +synonym: "MSH secretion" EXACT [GOC:cjm] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036161 +name: calcitonin secretion +namespace: biological_process +def: "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036162 +name: oxytocin production +namespace: biological_process +def: "The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain." [GOC:cjm, Wikipedia:Oxytocin] +comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular oxytocin levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting oxytocin molecules, or increased conversion from precursor molecules. +synonym: "oxytocin biosynthesis" NARROW [] +synonym: "oxytocin secretion" NARROW [] +is_a: GO:0010467 ! gene expression + +[Term] +id: GO:0036163 +name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG_REACTION:R06866, PMID:620805, PMID:7028108] +xref: KEGG_REACTION:R06866 +xref: RHEA:44768 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0036164 +name: cell-abiotic substrate adhesion +namespace: biological_process +def: "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules." [GOC:di] +synonym: "cell-abiotic surface adhesion" RELATED [GOC:di] +is_a: GO:0031589 ! cell-substrate adhesion + +[Term] +id: GO:0036165 +name: invasive growth in response to heat +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells as a result of an increase in temperature." [GOC:di, PMID:22365851] +synonym: "invasive growth in response to elevated temperature" EXACT [PMID:22365851] +synonym: "invasive growth in response to high temperature" EXACT [PMID:22365851] +synonym: "invasive growth in response to temperature stimulus" BROAD [GOC:di] +is_a: GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat +is_a: GO:0036267 ! invasive filamentous growth + +[Term] +id: GO:0036166 +name: phenotypic switching +namespace: biological_process +def: "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues." [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching] +comment: Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'. +synonym: "phenotypic dimorphism" RELATED [Wikipedia:Phenotypic_switching] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0036167 +name: phenotypic switching in response to host +namespace: biological_process +def: "A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching] +is_a: GO:0036166 ! phenotypic switching +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0036168 +name: filamentous growth of a population of unicellular organisms in response to heat +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature." [GOC:di, PMID:17554048] +is_a: GO:0009408 ! response to heat +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:0036169 +name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2." [GOC:mw, PMID:620805, PMID:7028108] +xref: Reactome:R-HSA-2162195 "MHDB is decarboxylated to DMPhOH by MHDB decarboxylase" +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0036170 +name: filamentous growth of a population of unicellular organisms in response to starvation +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment." [GOC:di, PMID:17554048] +is_a: GO:0042594 ! response to starvation +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:0036171 +name: filamentous growth of a population of unicellular organisms in response to chemical stimulus +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus." [GOC:di, PMID:17554048] +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0036172 +name: thiamine salvage +namespace: biological_process +def: "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis." [PMID:15150256, PMID:16952958] +xref: MetaCyc:PWY-6896 +xref: MetaCyc:PWY-6897 +xref: MetaCyc:PWY-6898 +is_a: GO:0008655 ! pyrimidine-containing compound salvage +is_a: GO:0009228 ! thiamine biosynthetic process + +[Term] +id: GO:0036173 +name: thiosulfate binding +namespace: molecular_function +def: "Binding to a thiosulfate, a sulfur oxide that has formula O3S2." [GOC:db, PMID:2188959] +is_a: GO:0043168 ! anion binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0036174 +name: butane monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O." [GOC:dh, PMID:17526838, PMID:19383682] +synonym: "sBMO" RELATED [PMID:19383682] +synonym: "soluble butane monooxygenase" RELATED [PMID:19383682] +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036175 +name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." [EC:1.17.4.1, GOC:bf, GOC:pde, PMID:7476363] +xref: Reactome:R-HSA-111742 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)" +xref: Reactome:R-HSA-8866405 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)" +is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:0036176 +name: response to neutral pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH] +is_a: GO:0009268 ! response to pH + +[Term] +id: GO:0036177 +name: filamentous growth of a population of unicellular organisms in response to pH +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH] +is_a: GO:0009268 ! response to pH +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:0036178 +name: filamentous growth of a population of unicellular organisms in response to neutral pH +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus." [GOC:di, PMID:6374461] +is_a: GO:0036176 ! response to neutral pH +is_a: GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH + +[Term] +id: GO:0036179 +name: osteoclast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg] +synonym: "chondroclast maturation" RELATED [CL:0000092] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0036035 ! osteoclast development + +[Term] +id: GO:0036180 +name: filamentous growth of a population of unicellular organisms in response to biotic stimulus +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus." [GOC:di] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:0036181 +name: protein localization to linear element +namespace: biological_process +def: "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689] +synonym: "protein localisation to linear element" EXACT [GOC:mah] +is_a: GO:1903084 ! protein localization to condensed nuclear chromosome + +[Term] +id: GO:0036182 +name: asperthecin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] +synonym: "asperthecin metabolism" EXACT [GOC:bf] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:0036183 +name: asperthecin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] +synonym: "asperthecin breakdown" EXACT [GOC:bf] +synonym: "asperthecin catabolism" EXACT [GOC:bf] +synonym: "asperthecin degradation" EXACT [GOC:bf] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0036182 ! asperthecin metabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:0036184 +name: asperthecin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [GOC:di] +synonym: "asperthecin biosynthesis" EXACT [GOC:bf] +synonym: "asperthecin formation" EXACT [GOC:bf] +synonym: "asperthecin synthesis" EXACT [GOC:bf] +is_a: GO:0036182 ! asperthecin metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0036185 +name: 13-lipoxin reductase activity +namespace: molecular_function +def: "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." [GOC:mw, PMID:10837478] +xref: Reactome:R-HSA-2161844 "15k-LXA4 is reduced to dhk-LXA4 by PTGR1" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036186 +name: early phagosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an early phagosome." [GOC:phg] +synonym: "early phagocytic vesicle membrane" EXACT [GOC:bf] +is_a: GO:0030670 ! phagocytic vesicle membrane +relationship: part_of GO:0032009 ! early phagosome + +[Term] +id: GO:0036187 +name: cell growth mode switching, budding to filamentous +namespace: biological_process +def: "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di] +synonym: "yeast to hyphal transition" RELATED [GOC:di] +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0036188 +name: abieta-7,13-dien-18-al dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+." [EC:1.2.1.74] +synonym: "abietadienal dehydrogenase" BROAD [EC:1.2.1.74] +xref: EC:1.2.1.74 +xref: KEGG_REACTION:R06357 +xref: MetaCyc:1.2.1.74-RXN +xref: RHEA:26225 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036189 +name: abieta-7,13-diene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O." [EC:1.14.14.144] +synonym: "abietadiene hydroxylase" BROAD [EC:1.14.14.144] +xref: EC:1.14.14.144 +xref: KEGG_REACTION:R06351 +xref: MetaCyc:RXN-8507 +xref: RHEA:26217 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036190 +name: indole-2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.137, RHEA:31899] +xref: EC:1.14.14.153 +xref: KEGG_REACTION:R07403 +xref: RHEA:31899 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036191 +name: indolin-2-one monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O." [EC:1.14.14.157, RHEA:31919] +synonym: "indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.14.157] +xref: EC:1.14.14.157 +xref: KEGG_REACTION:R07421 +xref: RHEA:31919 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036192 +name: 3-hydroxyindolin-2-one monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.139, RHEA:31927] +synonym: "3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming)" RELATED [EC:1.14.14.109] +xref: EC:1.14.14.109 +xref: KEGG_REACTION:R07422 +xref: RHEA:31927 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036193 +name: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.140] +xref: EC:1.14.14.110 +xref: KEGG_REACTION:R07423 +xref: RHEA:31939 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036194 +name: muscle cell projection +namespace: cellular_component +def: "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] +synonym: "muscle arm" NARROW [GOC:kmv] +synonym: "myocyte projection" EXACT [CL:0000187] +synonym: "myopodia" NARROW [GOC:kmv] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0036195 +name: muscle cell projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0036194 ! muscle cell projection + +[Term] +id: GO:0036196 +name: zymosterol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf] +is_a: GO:0016125 ! sterol metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0036197 +name: zymosterol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [GOC:yaf, MetaCyc:PWY-6074] +synonym: "zymosterol anabolism" EXACT [GOC:bf] +synonym: "zymosterol biosynthesis" EXACT [GOC:bf] +synonym: "zymosterol formation" EXACT [GOC:bf] +synonym: "zymosterol synthesis" EXACT [GOC:bf] +xref: MetaCyc:PWY-6074 +xref: UniPathway:UPA00770 +is_a: GO:0016126 ! sterol biosynthetic process +is_a: GO:0036196 ! zymosterol metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0036198 +name: dTMP salvage +namespace: biological_process +def: "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis." [GOC:yaf, UniPathway:UPA00578] +synonym: "deoxythymidine monophosphate biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578] +synonym: "dTMP biosynthesis via salvage pathway" RELATED [GOC:yaf, PMID:5387459, UniPathway:UPA00578] +xref: UniPathway:UPA00578 +is_a: GO:0006231 ! dTMP biosynthetic process +is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage + +[Term] +id: GO:0036199 +name: cholest-4-en-3-one 26-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate." [EC:1.14.15.29] +xref: EC:1.14.15.29 +xref: KEGG_REACTION:R09859 +xref: RHEA:51564 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036200 +name: 3-ketosteroid 9-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O." [EC:1.14.15.30] +synonym: "3-ketosteroid 9alpha-hydroxylase activity" RELATED [EC:1.14.13.142] +synonym: "KshAB activity" RELATED [EC:1.14.13.142] +xref: EC:1.14.15.30 +xref: KEGG_REACTION:R09860 +xref: RHEA:32199 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036201 +name: ent-isokaurene C2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+." [EC:1.14.14.76] +xref: EC:1.14.14.76 +xref: KEGG_REACTION:R09861 +xref: RHEA:56336 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036202 +name: ent-cassa-12,15-diene 11-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." [EC:1.14.14.112] +synonym: "ent-cassadiene C11alpha-hydroxylase activity" RELATED [EC:1.14.14.112] +xref: EC:1.14.14.112 +xref: KEGG_REACTION:R09866 +xref: RHEA:31967 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036203 +name: taxoid 14-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O." [EC:1.14.13.146] +xref: EC:1.14.13.146 +xref: KEGG_REACTION:R09867 +xref: RHEA:31971 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036204 +name: abieta-7,13-dien-18-ol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O." [EC:1.14.14.145] +xref: EC:1.14.14.145 +xref: KEGG_REACTION:R06354 +xref: MetaCyc:RXN-12799 +xref: RHEA:26221 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036205 +name: histone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells." [GOC:krc] +comment: This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. +synonym: "histone protein catabolic process" EXACT [GOC:bf, GOC:jl] +is_a: GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0036206 +name: obsolete regulation of histone gene expression +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] +comment: This term was obsoleted because it referes to a specific gene product. The gene product should be captured as an annotation extension using 'has input'. +synonym: "regulation of expression of histone-encoding gene" EXACT [GOC:bf] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0036207 +name: obsolete positive regulation of histone gene expression +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] +comment: This term was obsoleted because it referes to a specific gene product. The gene product should be captured as an annotation extension using 'has input'. +synonym: "activation of histone gene expression" NARROW [GOC:bf] +synonym: "positive regulation of expression of histone-encoding gene" EXACT [GOC:bf] +synonym: "up-regulation of histone gene expression" EXACT [GOC:bf] +synonym: "upregulation of histone gene expression" EXACT [GOC:bf] +is_obsolete: true +consider: GO:0045944 + +[Term] +id: GO:0036208 +name: obsolete negative regulation of histone gene expression +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc] +comment: This term was obsoleted because the gene product should be captured as an annotation extension using 'has input'. +synonym: "down-regulation of histone gene expression" EXACT [GOC:bf] +synonym: "downregulation of histone gene expression" EXACT [GOC:bf] +synonym: "inhibition of histone gene expression" NARROW [GOC:bf] +synonym: "negative regulation of expression of histone-encoding gene" EXACT [GOC:bf] +is_obsolete: true +consider: GO:0000122 + +[Term] +id: GO:0036209 +name: 9beta-pimara-7,15-diene oxidase activity +namespace: molecular_function +alt_id: GO:0102609 +def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]." [RHEA:31951] +comment: Formerly EC:1.14.13.144. +synonym: "9-beta-stemod-13(17)-ene oxidase activity" RELATED [] +xref: EC:1.14.14.111 +xref: KEGG_REACTION:R09865 +xref: MetaCyc:RXN-15437 +xref: RHEA:31951 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036210 +name: protein modification process in another organism +namespace: biological_process +def: "The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] +synonym: "protein modification in other organism" EXACT [GOC:bf] +synonym: "protein modification process in other organism" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0036211 +name: protein modification process +namespace: biological_process +def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] +subset: goslim_generic +synonym: "protein modification" EXACT [GOC:bf] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0043412 ! macromolecule modification + +[Term] +id: GO:0036212 +name: contractile ring maintenance +namespace: biological_process +def: "The process in which the contractile ring is maintained, typically in response to an internal or external cue." [GOC:mah, GOC:vw] +comment: This term can be used to annotate maintenance of either bacterial or fungal contractile rings. +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0043954 ! cellular component maintenance +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0036213 +name: contractile ring contraction +namespace: biological_process +def: "The process of an actomyosin ring getting smaller in diameter." [GOC:mah, GOC:vw] +comment: This term can be used to annotate contraction of either bacterial or fungal contractile rings. +synonym: "contractile ring constriction" EXACT [GOC:vw] +is_a: GO:0032506 ! cytokinetic process +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0036214 +name: contractile ring localization +namespace: biological_process +def: "The process in which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah, GOC:vw] +comment: This term can be used to annotate localization of either bacterial or fungal contractile rings. +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0051179 ! localization +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0036215 +name: response to stem cell factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh] +synonym: "response to hematopoietic growth factor KL" EXACT [PR:000009345] +synonym: "response to KIT ligand" EXACT [PR:000009345] +synonym: "response to SCF" EXACT [PR:000009345] +synonym: "response to stem cell factor stimulus" EXACT [GOC:dos] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0036216 +name: cellular response to stem cell factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444] +synonym: "cellular response to hematopoietic growth factor KL" EXACT [PR:000009345] +synonym: "cellular response to KIT ligand" EXACT [PR:000009345] +synonym: "cellular response to KITLG" EXACT [PMID:18787413] +synonym: "cellular response to SCF" EXACT [PR:000009345] +is_a: GO:0036215 ! response to stem cell factor +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0036217 +name: dGTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate." [GOC:dgf, PMID:17090528, PMID:22531138, RHEA:28362] +synonym: "2'-deoxyguanosine 5'-triphosphate diphosphohydrolase" EXACT [KEGG_REACTION:R01855] +xref: KEGG_REACTION:R01855 +xref: RHEA:28362 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036218 +name: dTTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate." [GOC:dgf, PMID:22531138, RHEA:28534] +xref: EC:3.6.1.9 +xref: MetaCyc:RXN0-5107 +xref: RHEA:28534 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036219 +name: GTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + H2O = GMP + diphosphate." [GOC:dgf, PMID:22531138, RHEA:29391] +synonym: "GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase" EXACT [KEGG_REACTION:R00426] +synonym: "GTP diphosphohydrolase activity" EXACT [GOC:bf] +xref: KEGG_REACTION:R00426 +xref: RHEA:29391 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036220 +name: ITP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ITP + H2O = IMP + diphosphate." [GOC:dgf, PMID:17899088, PMID:22531138] +synonym: "inosine-5'-triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00720] +xref: KEGG_REACTION:R00720 +xref: MetaCyc:RXN0-6382 +xref: Reactome:R-HSA-2509827 "ITPA hydrolyses ITP to IMP" +xref: RHEA:29399 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036221 +name: UTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + H2O = UMP + diphosphate." [GOC:dgf, PMID:17899088] +synonym: "uridine triphosphate pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R00662] +xref: KEGG_REACTION:R00662 +xref: RHEA:29395 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036222 +name: XTP diphosphatase activity +namespace: molecular_function +alt_id: GO:0103024 +def: "Catalysis of the reaction: XTP + H2O <=> H+ + XDP + monophosphate." [GOC:pz, PMID:16216582, PMID:22531138, RHEA:28610] +comment: While XTP is not produced by cells, deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP, XTP, and dXTP. XTPase contributes to the removal of these abnormal bases from the cellular pool of nucleotide triphosphates. +synonym: "hypoxanthine/xanthine dNTP pyrophosphatase" RELATED [EC:3.6.1.66] +synonym: "XTP pyrophosphohydrolase activity" EXACT [KEGG_REACTION:R02720] +synonym: "XTP/dITP diphosphatase" RELATED [EC:3.6.1.66] +synonym: "XTPase activity" EXACT [] +xref: EC:3.6.1.66 +xref: KEGG_REACTION:R02720 +xref: MetaCyc:RXN0-1603 +xref: MetaCyc:RXN0-5074 +xref: Reactome:R-HSA-2509831 "ITPA hydrolyses XTP to XMP" +xref: RHEA:28610 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0036223 +name: cellular response to adenine starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [GOC:ai] +synonym: "cellular response to adenine deprivation" EXACT [GOC:bf] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0036224 +name: pairing center +namespace: cellular_component +def: "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment." [GOC:kmv, PMID:18597662] +synonym: "homolog recognition region" EXACT [GOC:kmv] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0036225 +name: cellular response to vitamin B1 starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [GOC:al, Wikipedia:Thiamine] +synonym: "cellular response to thiamin starvation" EXACT [] +synonym: "cellular response to vitamin B1 deprivation" EXACT [GOC:bf] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0036226 +name: obsolete mitotic cell cycle arrest in response to glucose starvation +namespace: biological_process +def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201] +comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G2 cell cycle arrest in response to glucose starvation' has been observed. +synonym: "cell cycle arrest in response to glucose starvation" BROAD [] +is_obsolete: true + +[Term] +id: GO:0036227 +name: mitotic G2 cell cycle arrest in response to glucose starvation +namespace: biological_process +def: "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201] +is_a: GO:0051726 ! regulation of cell cycle + +[Term] +id: GO:0036228 +name: protein localization to nuclear inner membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane." [GOC:dgf, PMID:16929305] +synonym: "protein targeting to INM" RELATED [PMID:16929305] +synonym: "protein targeting to nuclear inner membrane" RELATED [] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:0090435 ! protein localization to nuclear envelope + +[Term] +id: GO:0036230 +name: granulocyte activation +namespace: biological_process +def: "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0036234 +name: deglucuronidation +namespace: biological_process +def: "The removal of glucuronic acid from a conjugated substrate." [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473] +is_a: GO:0019585 ! glucuronate metabolic process + +[Term] +id: GO:0036235 +name: acyl deglucuronidation +namespace: biological_process +def: "The removal of glucuronic acid from an acyl-glucuronide." [GOC:BHF, GOC:vk, PMID:22294686] +is_a: GO:0036234 ! deglucuronidation + +[Term] +id: GO:0036236 +name: acyl glucuronidation +namespace: biological_process +def: "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside)." [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686] +is_a: GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:0036237 +name: acyl-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate." [GOC:BHF, GOC:vk, PMID:22294686] +synonym: "acyl-glucuronide deglucuronidation activity" NARROW [PMID:22294686] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0036238 +name: gallate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate." [EC:1.13.11.57, PMID:16030014] +xref: EC:1.13.11.57 +xref: KEGG_REACTION:R09565 +xref: MetaCyc:GALLATE-DIOXYGENASE-RXN +xref: RHEA:28927 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0036239 +name: taxoid 7beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O." [EC:1.14.13.147] +xref: EC:1.14.13.147 +xref: KEGG_REACTION:R09868 +xref: MetaCyc:RXN-12885 +xref: RHEA:31975 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036240 +name: septal periplasm +namespace: cellular_component +def: "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi." [GOC:di, PMID:21564341] +synonym: "cell wall-enclosed septal periplasm" EXACT [GOC:di] +is_a: GO:0042597 ! periplasmic space + +[Term] +id: GO:0036241 +name: glutamate catabolic process to 4-hydroxybutyrate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321] +comment: In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase. +synonym: "glutamate degradation to 4-hydroxybutyrate" EXACT [MetaCyc:PWY-4321] +is_a: GO:0006538 ! glutamate catabolic process +is_a: GO:0046459 ! short-chain fatty acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0036242 +name: glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, MetaCyc:PWY-4321] +comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. +synonym: "glutamate degradation via gamma aminobutyrate transaminase activity" EXACT [MetaCyc:PWY-4321] +xref: MetaCyc:PWY-4321 +xref: MetaCyc:PWY3O-210 +is_a: GO:0006540 ! glutamate decarboxylation to succinate + +[Term] +id: GO:0036243 +name: succinate-semialdehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [GOC:bf, RHEA:13213] +comment: This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. +synonym: "NADP-dependent succinate-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.79] +synonym: "succinate semialdehyde:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.79] +synonym: "succinic semialdehyde dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.79] +synonym: "succinyl semialdehyde dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.79] +xref: EC:1.2.1.79 +xref: RHEA:13213 +is_a: GO:0009013 ! succinate-semialdehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0036244 +name: cellular response to neutral pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, Wikipedia:PH] +is_a: GO:0036176 ! response to neutral pH +is_a: GO:0071467 ! cellular response to pH + +[Term] +id: GO:0036245 +name: cellular response to menadione +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al, Wikipedia:Menadione] +synonym: "cellular response to vitamin K3" EXACT [GOC:al] +is_a: GO:0071307 ! cellular response to vitamin K +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0036246 +name: phytochelatin 2 import into vacuole +namespace: biological_process +def: "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] +synonym: "PC2 import into vacuole" EXACT [GOC:al] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0071995 ! phytochelatin import into vacuole + +[Term] +id: GO:0036247 +name: phytochelatin 3 import into vacuole +namespace: biological_process +def: "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] +synonym: "PC3 import into vacuole" EXACT [GOC:al] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0071995 ! phytochelatin import into vacuole + +[Term] +id: GO:0036248 +name: phytochelatin 4 import into vacuole +namespace: biological_process +def: "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [GOC:al, PMID:19001374] +synonym: "PC4 import into vacuole" EXACT [GOC:al] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0071995 ! phytochelatin import into vacuole + +[Term] +id: GO:0036249 +name: cadmium ion import into vacuole +namespace: biological_process +def: "The directed movement of cadmium ions into the vacuole." [GOC:al] +synonym: "vacuolar cadmium import" RELATED [GOC:bf] +is_a: GO:0000041 ! transition metal ion transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0036250 +name: peroxisome transport along microtubule +namespace: biological_process +def: "The directed movement of a peroxisome along a microtubule, mediated by motor proteins." [GOC:pm, PMID:21525035] +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0036251 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to salt stress +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045944 +consider: GO:0071472 + +[Term] +id: GO:0036252 +name: positive regulation of transcription from RNA polymerase II promoter in response to menadione +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [GOC:al] +synonym: "positive regulation of transcription from RNA polymerase II promoter in response to menadione stress" NARROW [GOC:al] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0036245 ! cellular response to menadione + +[Term] +id: GO:0036253 +name: response to amiloride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0036254 +name: cellular response to amiloride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [GOC:mah] +is_a: GO:0036253 ! response to amiloride +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0036255 +name: response to methylamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] +is_a: GO:0014075 ! response to amine + +[Term] +id: GO:0036256 +name: cellular response to methylamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [GOC:mah] +is_a: GO:0036255 ! response to methylamine +is_a: GO:0071418 ! cellular response to amine stimulus + +[Term] +id: GO:0036257 +name: multivesicular body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881] +synonym: "MVB organization" EXACT [GOC:bf] +is_a: GO:0007032 ! endosome organization + +[Term] +id: GO:0036258 +name: multivesicular body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114] +synonym: "multivesicular body biogenesis" EXACT [PMID:19571114] +synonym: "MVB biogenesis" EXACT [PMID:19571114] +synonym: "MVB formation" EXACT [PMID:19571114] +is_a: GO:0036257 ! multivesicular body organization +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:0036259 +name: aerobic raffinose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen." [GOC:al, PMID:10082789] +synonym: "aerobic raffinose breakdown" EXACT [GOC:bf] +synonym: "aerobic raffinose catabolism" EXACT [GOC:bf] +synonym: "aerobic raffinose degradation" EXACT [GOC:bf] +is_a: GO:0034484 ! raffinose catabolic process + +[Term] +id: GO:0036260 +name: RNA capping +namespace: biological_process +def: "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984, PMID:27383794, PMID:29681497, PMID:30353673] +is_a: GO:0006396 ! RNA processing + +[Term] +id: GO:0036261 +name: 7-methylguanosine cap hypermethylation +namespace: biological_process +def: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984] +synonym: "2,2,7-trimethylguanosine cap formation" EXACT [PMID:11983179] +synonym: "conversion of m(7)G to m(3)G" EXACT [PMID:11983179] +synonym: "hypermethylation of snoRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] +synonym: "hypermethylation of snRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] +synonym: "m(7)G cap hypermethylation" EXACT [GOC:bf] +synonym: "snoRNA capping" NARROW [GOC:rl] +synonym: "snRNA capping" NARROW [GOC:rl] +synonym: "TMG cap formation" EXACT [PMID:11983179] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0036260 ! RNA capping + +[Term] +id: GO:0036262 +name: granulysin production +namespace: biological_process +def: "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0036265 +name: RNA (guanine-N7)-methylation +namespace: biological_process +def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl] +is_a: GO:0001510 ! RNA methylation + +[Term] +id: GO:0036266 +name: Cdc48p-Npl4p-Vms1p AAA ATPase complex +namespace: cellular_component +def: "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p." [GOC:rn, PMID:21070972, PMID:21936843] +synonym: "Cdc48p-Npl4p-Vms1p complex" EXACT [GOC:rn] +synonym: "Vms1-Cdc48-Npl4 complex" EXACT [GOC:rn] +synonym: "Vms1p-Cdc48p-Npl4p complex" EXACT [GOC:rn] +is_a: GO:0098799 ! outer mitochondrial membrane protein complex + +[Term] +id: GO:0036267 +name: invasive filamentous growth +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells into a substrate." [GOC:di, PMID:22276126] +synonym: "invasive growth" EXACT [GOC:di] +is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0036268 +name: swimming +namespace: biological_process +def: "Self-propelled movement of an organism from one location to another through water, often by means of active fin movement." [GOC:cvs, PMID:22459995] +comment: For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'. +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0036269 +name: swimming behavior +namespace: biological_process +def: "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679] +synonym: "swimming behaviour" EXACT [PMID:16764679] +is_a: GO:0007626 ! locomotory behavior + +[Term] +id: GO:0036270 +name: response to diuretic +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0036271 +name: response to methylphenidate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [GOC:hp, Wikipedia:Methylphenidate] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to MPD" EXACT [CHEBI:6887] +synonym: "response to MPH" EXACT [CHEBI:6887] +synonym: "response to ritalin" EXACT [CHEBI:6887] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0036272 +name: response to gemcitabine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [GOC:hp, Wikipedia:Gemcitabine] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to 2',2'-difluorodeoxycytidine" EXACT [CHEBI:175901] +synonym: "response to 2'-deoxy-2',2'-difluorocytidine" EXACT [CHEBI:175901] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0036273 +name: response to statin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to HMG-CoA reductase inhibitor" RELATED [CHEBI:35664] +synonym: "response to hydroxymethylglutaryl-CoA reductase inhibitor" RELATED [CHEBI:35664] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0036274 +name: response to lapatinib +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0036275 +name: response to 5-fluorouracil +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to 5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT [CHEBI:46345] +synonym: "response to fluorouracil" EXACT [GOC:hp] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0036276 +name: response to antidepressant +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0036277 +name: response to anticonvulsant +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0036278 +name: positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen." [GOC:al, PMID:21118960] +is_a: GO:0006995 ! cellular response to nitrogen starvation +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0036279 +name: positive regulation of protein export from nucleus in response to glucose starvation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose." [GOC:al, PMID:3541942] +is_a: GO:0042149 ! cellular response to glucose starvation +is_a: GO:0046827 ! positive regulation of protein export from nucleus + +[Term] +id: GO:0036280 +name: cellular response to L-canavanine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [GOC:al] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1901354 ! response to L-canavanine + +[Term] +id: GO:0036283 +name: obsolete positive regulation of transcription factor import into nucleus in response to oxidative stress +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress." [GOC:al, PMID:9585505] +comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. +synonym: "positive regulation of transcription factor import into nucleus in response to hydrogen peroxide" RELATED [GOC:al] +is_obsolete: true +consider: GO:0034599 +consider: GO:0042307 + +[Term] +id: GO:0036284 +name: tubulobulbar complex +namespace: cellular_component +def: "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523] +synonym: "TBC" EXACT [GOC:sl, PMID:22510523] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0036285 +name: SAGA complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315] +synonym: "SAGA complex formation" EXACT [GOC:bf] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0036286 +name: eisosome filament +namespace: cellular_component +def: "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945] +synonym: "linear eisosome" EXACT [GOC:vw] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030863 ! cortical cytoskeleton +relationship: part_of GO:0032126 ! eisosome + +[Term] +id: GO:0036287 +name: response to iloperidone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:0071867 ! response to monoamine +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0036288 +name: response to ximelagatran +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0036289 +name: peptidyl-serine autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein." [GOC:pm] +synonym: "serine autophosphorylation" EXACT [GOC:bf] +is_a: GO:0018105 ! peptidyl-serine phosphorylation +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0036290 +name: protein trans-autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151] +synonym: "trans-autophosphorylation" EXACT [GOC:jsg] +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0036291 +name: protein cis-autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own amino acid residues." [GOC:jsg, PMID:9201908] +synonym: "cis-autophosphorylation" EXACT [GOC:jsg] +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0036292 +name: DNA rewinding +namespace: biological_process +def: "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634] +synonym: "DNA annealing" RELATED [GOC:sp] +synonym: "RPA-dependent DNA rewinding" NARROW [PMID:21078962] +synonym: "single-stranded DNA bubble rewinding" NARROW [PMID:18974355] +is_a: GO:0032392 ! DNA geometric change + +[Term] +id: GO:0036293 +name: response to decreased oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] +comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. +synonym: "response to lowered oxygen levels" EXACT [GOC:bf] +is_a: GO:0070482 ! response to oxygen levels + +[Term] +id: GO:0036294 +name: cellular response to decreased oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] +comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'. +synonym: "cellular response to lowered oxygen levels" EXACT [GOC:bf] +is_a: GO:0036293 ! response to decreased oxygen levels +is_a: GO:0071453 ! cellular response to oxygen levels + +[Term] +id: GO:0036295 +name: cellular response to increased oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al] +comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'cellular response to hyperoxia ; GO:0071455'. +synonym: "cellular response to raised oxygen levels" EXACT [GOC:bf] +is_a: GO:0036296 ! response to increased oxygen levels +is_a: GO:0071453 ! cellular response to oxygen levels + +[Term] +id: GO:0036296 +name: response to increased oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al] +comment: This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'response to hyperoxia ; GO:0055093. +synonym: "response to raised oxygen levels" EXACT [GOC:bf] +is_a: GO:0070482 ! response to oxygen levels + +[Term] +id: GO:0036297 +name: interstrand cross-link repair +namespace: biological_process +def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477] +synonym: "ICL repair" EXACT [PMID:20658649] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0036298 +name: recombinational interstrand cross-link repair +namespace: biological_process +def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region." [GOC:vw, PMID:20658649] +synonym: "recombination-dependent interstrand cross-link repair" EXACT [GOC:vw] +is_a: GO:0000725 ! recombinational repair +is_a: GO:0036297 ! interstrand cross-link repair + +[Term] +id: GO:0036299 +name: non-recombinational interstrand cross-link repair +namespace: biological_process +def: "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination." [GOC:vw, PMID:11154259, PMID:22064477] +synonym: "recombination-independent ICL repair" EXACT [GOC:vw] +synonym: "recombination-independent interstrand cross-link repair" EXACT [GOC:vw] +is_a: GO:0036297 ! interstrand cross-link repair + +[Term] +id: GO:0036300 +name: B cell receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell." [GOC:add, GOC:amm] +synonym: "B cell receptor uptake of antigen" NARROW [PMID:10996020] +synonym: "BCR endocytosis" EXACT [GOC:bf] +synonym: "BCR receptor internalization" EXACT [GOC:amm] +is_a: GO:0031623 ! receptor internalization + +[Term] +id: GO:0036301 +name: macrophage colony-stimulating factor production +namespace: biological_process +def: "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk] +subset: gocheck_do_not_annotate +synonym: "M-CSF production" EXACT [GOC:vk] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0036302 +name: atrioventricular canal development +namespace: biological_process +def: "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle." [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0036303 +name: lymph vessel morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001945 ! lymph vessel development + +[Term] +id: GO:0036304 +name: umbilical cord morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0061027 ! umbilical cord development + +[Term] +id: GO:0036305 +name: ameloblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0036306 +name: embryonic heart tube elongation +namespace: biological_process +def: "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:BHF, GOC:gr, PMID:15901664] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035050 ! embryonic heart tube development + +[Term] +id: GO:0036307 +name: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA." [GOC:imk, PMID:22847818] +is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity + +[Term] +id: GO:0036308 +name: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine." [GOC:imk, PMID:22079366] +is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity + +[Term] +id: GO:0036309 +name: protein localization to M-band +namespace: biological_process +def: "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere." [GOC:BHF, GOC:rl, PMID:18782775] +synonym: "cellular protein localization to M-band" EXACT [GOC:rl] +synonym: "protein localization to M disc" EXACT [GOC:rl] +synonym: "protein localization to M line" NARROW [GOC:rl] +synonym: "protein localization to mesophragma" EXACT [GOC:rl] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0036310 +name: ATP-dependent DNA/DNA annealing activity +namespace: molecular_function +def: "An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405] +synonym: "annealing helicase activity" RELATED [PMID:22888405] +synonym: "ATP-dependent DNA annealing activity" RELATED [GOC:sp] +synonym: "DNA rewinding activity" RELATED [PMID:22888405] +synonym: "nucleoside-triphosphatase activity involved in DNA annealing" EXACT [GOC:bf] +xref: Reactome:R-HSA-5686642 "RAD52 promotes single strand annealing at resected DNA DSBs" +is_a: GO:0140657 ! ATP-dependent activity +is_a: GO:1990814 ! DNA/DNA annealing activity + +[Term] +id: GO:0036311 +name: chitin disaccharide deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate." [EC:3.5.1.105, GOC:imk] +comment: In contrast to EC:3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide. +synonym: "chitin oligosaccharide amidohydrolase activity" RELATED [EC:3.5.1.105] +synonym: "chitin oligosaccharide deacetylase activity" RELATED [EC:3.5.1.105] +synonym: "chitobiose amidohydrolase activity" RELATED [EC:3.5.1.105] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0036312 +name: phosphatidylinositol 3-kinase regulatory subunit binding +namespace: molecular_function +def: "Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location." [GOC:bf, PMID:20505341] +synonym: "p85 binding" RELATED [PMID:10627473, PMID:20505341] +synonym: "PI3K regulatory subunit binding" EXACT [GOC:bf] +is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding + +[Term] +id: GO:0036313 +name: phosphatidylinositol 3-kinase catalytic subunit binding +namespace: molecular_function +def: "Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214] +synonym: "p110 binding" RELATED [PMID:17475214] +synonym: "PI3K catalytic subunit binding" EXACT [GOC:bf] +is_a: GO:0019900 ! kinase binding +is_a: GO:0043548 ! phosphatidylinositol 3-kinase binding + +[Term] +id: GO:0036314 +name: response to sterol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0036315 +name: cellular response to sterol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [GOC:bf] +is_a: GO:0036314 ! response to sterol +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0036316 +name: SREBP-SCAP complex retention in endoplasmic reticulum +namespace: biological_process +def: "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117] +comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937. +is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum +is_a: GO:2000639 ! negative regulation of SREBP signaling pathway +relationship: part_of GO:0036315 ! cellular response to sterol + +[Term] +id: GO:0036317 +name: tyrosyl-RNA phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis." [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287] +synonym: "unlinkase activity" EXACT [PMID:21408223] +synonym: "uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity" EXACT [PMID:21408223] +synonym: "VPg unlinkase activity" EXACT [GOC:sp, PMID:21408223, PMID:22908287] +synonym: "Y-pUpN PDE activity" EXACT [PMID:21408223] +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0036318 +name: peptide pheromone receptor activity +namespace: molecular_function +def: "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:al] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity +is_a: GO:0016503 ! pheromone receptor activity + +[Term] +id: GO:0036319 +name: mating-type M-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [GOC:al, PMID:7941744] +synonym: "M-factor mating pheromone receptor activity" EXACT [] +synonym: "M-factor receptor activity" EXACT [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity +is_a: GO:0036318 ! peptide pheromone receptor activity + +[Term] +id: GO:0036320 +name: mating-type P-factor pheromone receptor activity +namespace: molecular_function +def: "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [GOC:al, PMID:8314086] +synonym: "P-factor mating pheromone receptor activity" EXACT [] +synonym: "P-factor receptor activity" EXACT [] +is_a: GO:0004932 ! mating-type factor pheromone receptor activity +is_a: GO:0036318 ! peptide pheromone receptor activity + +[Term] +id: GO:0036321 +name: ghrelin secretion +namespace: biological_process +def: "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin] +synonym: "pancreatic ghrelin secretion" NARROW [GOC:cjm] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036322 +name: pancreatic polypeptide secretion +namespace: biological_process +def: "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide] +synonym: "PP secretion" NARROW [GOC:cjm] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0036323 +name: vascular endothelial growth factor receptor-1 signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:FLT1, Wikipedia:VEGF_receptors] +synonym: "FLT1 signaling pathway" EXACT [GOC:uh, PR:000007563] +synonym: "VEGFR-1 signaling pathway" EXACT [PR:000007563, Reactome:R-HSA-194311, Wikipedia:VEGF_receptors] +synonym: "VEGFR1 signaling pathway" EXACT [Reactome:R-HSA-194311] +is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0036324 +name: vascular endothelial growth factor receptor-2 signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] +synonym: "FLK-1 signaling pathway" EXACT [PR:000002112] +synonym: "KDR signaling pathway" EXACT [GOC:uh, PR:000002112, Wikipedia:Kinase_insert_domain_receptor] +synonym: "VEGFR-2 signaling pathway" EXACT [PR:000002112, Reactome:R-HSA-194310, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors] +synonym: "VEGFR2 signaling pathway" EXACT [Reactome:R-HSA-194310] +is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0036325 +name: vascular endothelial growth factor receptor-3 signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3] +synonym: "FLT4 signaling pathway" EXACT [GOC:uh, PR:000007565] +synonym: "VEGFR-3 signaling pathway" EXACT [Reactome:R-HSA-194308, Wikipedia:VEGF_receptors] +synonym: "VEGFR3 signaling pathway" EXACT [Reactome:R-HSA-194310, Wikipedia:VEGFR3] +is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway + +[Term] +id: GO:0036331 +name: avascular cornea development in camera-type eye +namespace: biological_process +def: "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees." [GOC:uh, PMID:16849433, PMID:17051153] +synonym: "avascular cornea development" EXACT [GOC:bf] +is_a: GO:0061303 ! cornea development in camera-type eye + +[Term] +id: GO:0036332 +name: placental growth factor-activated receptor activity +namespace: molecular_function +def: "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, Wikipedia:Placental_growth_factor] +synonym: "placental growth factor receptor activity" EXACT [GOC:bf] +synonym: "PlGF receptor activity" RELATED [PMID:12871269] +synonym: "PlGF-activated receptor activity" EXACT [GOC:uh, PMID:12871269] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity + +[Term] +id: GO:0036333 +name: hepatocyte homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874] +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0036334 +name: epidermal stem cell homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529] +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0036335 +name: intestinal stem cell homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863] +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0036336 +name: dendritic cell migration +namespace: biological_process +def: "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990] +is_a: GO:0071674 ! mononuclear cell migration + +[Term] +id: GO:0036337 +name: Fas signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily." [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor] +synonym: "Apo-1 signaling pathway" EXACT [PMID:12040174] +synonym: "CD95 signaling pathway" EXACT [PMID:12040174] +synonym: "FAS ligand-Fas signaling pathway" NARROW [PMID:12040174] +synonym: "Fas receptor signaling pathway" EXACT [Wikipedia:Fas_receptor] +synonym: "Fas-FasL signaling pathway" NARROW [GOC:bf] +synonym: "FasL signaling pathway" RELATED [Wikipedia:Fas_ligand] +synonym: "FasR signaling pathway" EXACT [Wikipedia:Fas_receptor] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0036338 +name: viral membrane +namespace: cellular_component +def: "The lipid bilayer of a virion, a complete fully infectious extracellular virus particle." [GOC:bm] +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0036339 +name: lymphocyte adhesion to endothelial cell of high endothelial venule +namespace: biological_process +def: "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules] +comment: For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'. +synonym: "lymphocyte adhesion to HEV cell" EXACT [PMID:7679710, Wikipedia:High_endothelial_venules] +synonym: "lymphocyte adhesion to high endothelial venule" EXACT [GOC:nhn] +is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell + +[Term] +id: GO:0036340 +name: chitin-based cuticle sclerotization by biomineralization +namespace: biological_process +def: "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate." [GOC:sart] +synonym: "chitin-based cuticle hardening by biomineralisation" EXACT [GOC:bf] +is_a: GO:0007593 ! chitin-based cuticle sclerotization +is_a: GO:0031214 ! biomineral tissue development + +[Term] +id: GO:0036341 +name: chitin-based cuticle sclerotization by protein cross-linking +namespace: biological_process +def: "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle." [GOC:bf, GOC:sart] +synonym: "chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning" NARROW [GOC:bf, GOC:dos, GOC:sart] +is_a: GO:0007593 ! chitin-based cuticle sclerotization + +[Term] +id: GO:0036342 +name: post-anal tail morphogenesis +namespace: biological_process +def: "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0036343 +name: psychomotor behavior +namespace: biological_process +def: "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning] +is_a: GO:0061744 ! motor behavior + +[Term] +id: GO:0036344 +name: platelet morphogenesis +namespace: biological_process +def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation + +[Term] +id: GO:0036345 +name: platelet maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] +is_a: GO:0048469 ! cell maturation + +[Term] +id: GO:0036346 +name: cellular response to L-cysteine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration." [GOC:al] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1901367 ! response to L-cysteine + +[Term] +id: GO:0036348 +name: hydantoin racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin." [EC:5.1.99.5, InterPro:IPR015942] +xref: EC:5.1.99.5 +xref: KEGG_REACTION:R09704 +xref: MetaCyc:RXN-9781 +xref: RHEA:46624 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0036349 +name: galactose-specific flocculation +namespace: biological_process +alt_id: GO:0098611 +def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069] +synonym: "cell-cell adhesion involved in galactose-specific flocculation" EXACT [] +is_a: GO:0000128 ! flocculation + +[Term] +id: GO:0036350 +name: mannose-specific flocculation +namespace: biological_process +alt_id: GO:0098612 +def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992] +synonym: "cell-cell adhesion involved in mannose-specific flocculation" EXACT [] +is_a: GO:0000128 ! flocculation + +[Term] +id: GO:0036351 +name: histone H2A-K13 ubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979] +synonym: "histone H2A ubiquitination (H2A-K13)" EXACT [GOC:sp] +is_a: GO:0033522 ! histone H2A ubiquitination + +[Term] +id: GO:0036352 +name: histone H2A-K15 ubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979] +synonym: "histone H2A ubiquitination (H2A-K15)" EXACT [GOC:sp] +is_a: GO:0033522 ! histone H2A ubiquitination + +[Term] +id: GO:0036353 +name: histone H2A-K119 monoubiquitination +namespace: biological_process +def: "The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022] +synonym: "histone H2A monoubiquitination (H2A-K119)" EXACT [GOC:sp] +is_a: GO:0035518 ! histone H2A monoubiquitination + +[Term] +id: GO:0036354 +name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569] +xref: MetaCyc:RXN-8787 +xref: RHEA:19733 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0036355 +name: 2-iminoacetate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671] +xref: EC:4.1.99.19 +xref: MetaCyc:RXN-11319 +xref: RHEA:26361 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0036356 +name: cyclic 2,3-diphosphoglycerate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate." [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660] +comment: This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). +synonym: "cDPGS activity" EXACT [PMID:9811660] +synonym: "CPGS activity" EXACT [GOC:bf] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0036357 +name: 2-phosphoglycerate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP." [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166] +comment: This reaction is the first step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). +synonym: "2PGK activity" EXACT [GOC:bf] +xref: EC:2.7.2.- +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0036358 +name: lipoteichoic acid D-alanylation +namespace: biological_process +def: "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA)." [GOC:crds, PMID:22750871, PMID:8682792] +synonym: "D-alanyl lipoteichoic acid formation" EXACT [PMID:8682792] +synonym: "D-alanyl LTA formation" EXACT [PMID:8682792] +synonym: "LTA D-alanylation" EXACT [PMID:22750871] +is_a: GO:0070400 ! teichoic acid D-alanylation + +[Term] +id: GO:0036359 +name: renal potassium excretion +namespace: biological_process +def: "The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:gap, PMID:15034090, PMID:25287933] +synonym: "renal K(+) excretion" EXACT [PMID:16014448] +synonym: "renal K+ elimination" EXACT [PMID:15034090] +synonym: "renal potassium ion excretion" EXACT [GOC:bf] +is_a: GO:0097254 ! renal tubular secretion + +[Term] +id: GO:0036360 +name: sorocarp stalk morphogenesis +namespace: biological_process +def: "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDANAT:0000068, GOC:pf, PMID:22902739] +synonym: "fruiting body stalk morphogenesis" BROAD [DDANAT:0000068] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0031150 ! sorocarp stalk development +relationship: part_of GO:0031288 ! sorocarp morphogenesis + +[Term] +id: GO:0036361 +name: racemase activity, acting on amino acids and derivatives +namespace: molecular_function +def: "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative." [GOC:crds] +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0036362 +name: ascus membrane +namespace: cellular_component +def: "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi." [GOC:mcc, GOC:vw, PMID:21900489] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0036363 +name: transforming growth factor beta activation +namespace: biological_process +def: "The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms." [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210] +synonym: "L-TGF-beta activation" EXACT [PMID:2070685] +synonym: "latent TGF-beta activation" EXACT [PMID:2070685] +synonym: "TGF-B activation" EXACT [GOC:sl] +synonym: "TGF-beta activation" EXACT [PR:000000046] +synonym: "TGFB activation" EXACT [GOC:sl] +synonym: "TGFbeta activation" EXACT [GOC:bf] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0036364 +name: transforming growth factor beta1 activation +namespace: biological_process +def: "The release of transforming growth factor beta1 (TGF-beta1) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] +synonym: "L-TGF-beta 1 activation" EXACT [PMID:2070685] +synonym: "latent-TGF-beta1 activation" EXACT [PMID:19439069] +synonym: "TGF-beta 1 activation" EXACT [PR:000000182] +synonym: "TGFB1 activation" EXACT [PR:000000182] +synonym: "TGFbeta 1 activation" EXACT [GOC:bf] +synonym: "transforming growth factor-beta1 activation" EXACT [PMID:19513812] +is_a: GO:0036363 ! transforming growth factor beta activation +relationship: part_of GO:0032905 ! transforming growth factor beta1 production + +[Term] +id: GO:0036365 +name: transforming growth factor beta2 activation +namespace: biological_process +def: "The release of transforming growth factor beta 2 (TGF-beta2) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] +synonym: "TGF-beta 2 activation" EXACT [PR:000000183] +synonym: "TGFB2 activation" EXACT [PR:000000183] +synonym: "TGFbeta 2 activation" EXACT [GOC:bf] +is_a: GO:0036363 ! transforming growth factor beta activation +relationship: part_of GO:0032906 ! transforming growth factor beta2 production + +[Term] +id: GO:0036366 +name: transforming growth factor beta3 activation +namespace: biological_process +def: "The release of transforming growth factor beta 3 (TGF-beta3) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210] +synonym: "TGF-beta 3 activation" EXACT [PR:000000184] +synonym: "TGFB3 activation" EXACT [PR:000000184] +synonym: "TGFbeta 3 activation" EXACT [GOC:bf] +is_a: GO:0036363 ! transforming growth factor beta activation +relationship: part_of GO:0032907 ! transforming growth factor beta3 production + +[Term] +id: GO:0036367 +name: light adaption +namespace: biological_process +def: "The ability of a photoreceptor to adjust to varying levels of light." [GOC:gap, PMID:16039565] +comment: Light adaptation is usually a combination of cell desensitization and response acceleration. +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0036368 +name: cone photoresponse recovery +namespace: biological_process +def: "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers." [GOC:gap, PMID:16039565, PMID:22802362] +synonym: "cone phototransduction termination" RELATED [GOC:bf] +synonym: "cone response recovery" EXACT [PMID:12732716] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:0036369 +name: transcription factor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:al, GOC:vw, PMID:22833559] +synonym: "proteasome-mediated transcription factor catabolism" EXACT [GOC:bf] +synonym: "sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:bf] +synonym: "transcription factor breakdown" EXACT [GOC:bf] +synonym: "transcription factor catabolism" EXACT [GOC:bf] +synonym: "transcription factor degradation" EXACT [PMID:22833559] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0036370 +name: D-alanyl carrier activity +namespace: molecular_function +def: "Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG)." [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792] +synonym: "D-alanyl carrier protein" RELATED [GOC:crds, PMID:11222605] +is_a: GO:0140414 ! phosphopantetheine-dependent carrier activity + +[Term] +id: GO:0036371 +name: protein localization to T-tubule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:BHF, GOC:rl, PMID:16292983] +synonym: "protein localisation to T-tubule" EXACT [GOC:rl] +synonym: "protein localization to T tubule" EXACT [GOC:rl] +synonym: "protein localization to transverse tubule" EXACT [GOC:rl] +is_a: GO:0072659 ! protein localization to plasma membrane + +[Term] +id: GO:0036372 +name: opsin transport +namespace: biological_process +def: "The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:atm, PMID:20238016, PMID:22855808] +synonym: "ciliary transport of opsin" NARROW [GOC:20238016] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0036373 +name: L-fucose mutarotase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-L-fucose = beta-L-fucose." [GOC:crds, PMID:15060078, RHEA:25580] +synonym: "alpha-L-fucose 1-epimerase activity" RELATED [EC:5.1.3.29] +synonym: "fucose 1-epimerase activity" RELATED [EC:5.1.3.29] +synonym: "type-2 mutarotase activity" RELATED [EC:5.1.3.29] +xref: EC:5.1.3.29 +xref: MetaCyc:RXN0-5298 +xref: RHEA:25580 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0036374 +name: glutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk] +synonym: "gamma-glutamyltranspeptidase activity" RELATED [EC:3.4.19.13] +synonym: "glutathionase activity" RELATED [EC:3.4.19.13] +xref: EC:3.4.19.13 +xref: KEGG_REACTION:R00494 +xref: MetaCyc:RXN-12618 +xref: Reactome:R-HSA-1222712 "Nitrosoglutathione gets cleaved to Cys(NO)-Gly" +xref: Reactome:R-HSA-266046 "GGT1, 5 dimers hydrolyse LTC4 to LTD4" +xref: Reactome:R-HSA-5433072 "GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG" +xref: Reactome:R-HSA-5602984 "Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG" +xref: Reactome:R-HSA-8943279 "GGT dimers hydrolyse GSH" +xref: Reactome:R-HSA-9026757 "GGT hydrolyses MCTR1 to MCTR2" +xref: Reactome:R-HSA-9026907 "GGT hydrolyses PCTR2 to PCTR3" +xref: Reactome:R-HSA-9026912 "GGT hydrolyses PCTR1 to PCTR2" +xref: Reactome:R-HSA-9026916 "GGT hydrolyses RCTR2 to RCTR3" +xref: Reactome:R-HSA-9026927 "GGT hydrolyses RCTR1 to RCTR2" +xref: Reactome:R-HSA-9035966 "Defective GGT1 does not hydrolyse GSH" +xref: RHEA:28807 +is_a: GO:0008242 ! omega peptidase activity +is_a: GO:0070003 ! threonine-type peptidase activity + +[Term] +id: GO:0036375 +name: Kibra-Ex-Mer complex +namespace: cellular_component +def: "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598] +synonym: "Kbr, Ex and Mer complex" EXACT [PMID:20159598] +synonym: "KEM complex" EXACT [PMID:20159598] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0036376 +name: sodium ion export across plasma membrane +namespace: biological_process +alt_id: GO:0071436 +alt_id: GO:0098667 +def: "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:14674689] +synonym: "sodium export" RELATED [GOC:mah] +synonym: "sodium ion export" RELATED [] +synonym: "sodium ion export from cell" EXACT [] +is_a: GO:0035725 ! sodium ion transmembrane transport +is_a: GO:0070839 ! metal ion export +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0036377 +name: arbuscular mycorrhizal association +namespace: biological_process +def: "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil." [GOC:sk, Wikipedia:Arbuscular_mycorrhiza] +synonym: "arbuscular mycorrhizae formation" EXACT [Wikipedia:Arbuscular_mycorrhiza] +synonym: "arbuscular mycorrhizal symbiosis" RELATED [Wikipedia:Arbuscular_mycorrhiza] +synonym: "arbuscular mycorrhizas formation" EXACT [Wikipedia:Arbuscular_mycorrhiza] +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0036378 +name: calcitriol biosynthetic process from calciol +namespace: biological_process +def: "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol." [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049] +synonym: "1alpha,25(OH)2D3 biosynthesis" BROAD [CHEBI:17823] +synonym: "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD [CHEBI:17823] +synonym: "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD [CHEBI:17823] +synonym: "calcitriol biosynthesis from calciol" EXACT [GOC:bf] +synonym: "vitamin D3 activation" EXACT [GOC:bf, PMID:20506379] +is_a: GO:0042368 ! vitamin D biosynthetic process +is_a: GO:0044108 ! cellular alcohol biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0070640 ! vitamin D3 metabolic process + +[Term] +id: GO:0036379 +name: myofilament +namespace: cellular_component +def: "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament] +synonym: "striated muscle filament" EXACT [GOC:bf] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030016 ! myofibril + +[Term] +id: GO:0036380 +name: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.33, GOC:rs] +synonym: "GlcNAc-P-P-Und synthase activity" RELATED [EC:2.7.8.33] +synonym: "UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity" RELATED [EC:2.7.8.33] +synonym: "UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.33] +synonym: "UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity" RELATED [EC:2.7.8.33] +synonym: "UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity" RELATED [EC:2.7.8.33] +xref: EC:2.7.8.33 +xref: KEGG_REACTION:R08856 +xref: MetaCyc:GLCNACPTRANS-RXN +xref: RHEA:28090 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0036381 +name: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate." [EC:4.3.3.6, GOC:rs] +synonym: "PdxST activity" RELATED [EC:4.3.3.6] +synonym: "pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity" RELATED [EC:4.3.3.6] +xref: EC:4.3.3.6 +xref: KEGG_REACTION:R10089 +xref: MetaCyc:RXN-11322 +xref: RHEA:31507 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0036382 +name: flavin reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced flavin + NAD+ = flavin + NADH + H+." [EC:1.5.1.36, GOC:rs] +synonym: "flavin:NADH oxidoreductase activity" RELATED [EC:1.5.1.36] +synonym: "NADH-dependent flavin reductase activity" RELATED [EC:1.5.1.36] +xref: EC:1.5.1.36 +xref: KEGG_REACTION:R09662 +xref: MetaCyc:1.5.1.36-RXN +xref: RHEA:31303 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036383 +name: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O." [EC:1.14.14.12, GOC:rs] +xref: EC:1.14.14.12 +xref: KEGG_REACTION:R09819 +xref: MetaCyc:1.14.14.12-RXN +xref: RHEA:31731 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0036384 +name: cytidine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP + H2O = CMP + phosphate." [GOC:al, RHEA:64880] +synonym: "CDPase activity" EXACT [GOC:al] +xref: RHEA:64880 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0036385 +name: nucleoid DNA packaging +namespace: biological_process +def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm] +is_a: GO:0006323 ! DNA packaging + +[Term] +id: GO:0036386 +name: bacterial nucleoid DNA packaging +namespace: biological_process +def: "Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520] +synonym: "chromosomal compaction" BROAD [PMID:17097674] +synonym: "nucleoid compaction" BROAD [PMID:17097674] +synonym: "prokaryotic DNA condensation" BROAD [Wikipedia:DNA_condensation] +is_a: GO:0036385 ! nucleoid DNA packaging + +[Term] +id: GO:0036387 +name: pre-replicative complex +namespace: cellular_component +def: "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex] +comment: This term describes pre-replicative complexes across organisms. +synonym: "pre-RC" EXACT [Wikipedia:Pre-replication_complex] +synonym: "pre-replication complex" EXACT [Wikipedia:Pre-replication_complex] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0036388 +name: pre-replicative complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2] +synonym: "pre-RC assembly" EXACT [Wikipedia:Pre-replication_complex] +synonym: "pre-replication complex assembly" RELATED [Wikipedia:Pre-replication_complex] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0036389 +name: bacterial pre-replicative complex +namespace: cellular_component +def: "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex] +synonym: "bacterial pre-RC" EXACT [GOC:bf, GOC:bhm, GOC:jh2] +is_a: GO:0036387 ! pre-replicative complex + +[Term] +id: GO:0036390 +name: pre-replicative complex assembly involved in bacterial-type DNA replication +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796] +synonym: "bacterial pre-RC assembly" EXACT [GOC:bf, GOC:bhm, GOC:jh2] +synonym: "bacterial pre-replicative complex assembly" EXACT [] +is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:0036391 +name: medial cortex septin ring +namespace: cellular_component +def: "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins." [GOC:vw, PMID:16009555] +is_a: GO:0005940 ! septin ring +is_a: GO:0032161 ! cleavage apparatus septin structure +relationship: part_of GO:0031097 ! medial cortex + +[Term] +id: GO:0036392 +name: chemokine (C-C motif) ligand 20 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc] +subset: gocheck_do_not_annotate +synonym: "C-C motif chemokine 20 production" EXACT [] +synonym: "CCL-20 production" EXACT [] +synonym: "CCL20 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0036393 +name: thiocyanate peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate." [GOC:pm, PMID:12626341] +synonym: "lactoperoxidase activity" BROAD [PMID:12626341, Wikipedia:Lactoperoxidase] +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0036394 +name: amylase secretion +namespace: biological_process +def: "The controlled release of amylase from a cell." [GOC:jc, PMID:19028687] +synonym: "amylase release" EXACT [PMID:19028687] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0036395 +name: pancreatic amylase secretion +namespace: biological_process +def: "The controlled release of amylase from a cell of the pancreas." [GOC:jc, PMID:19028687] +is_a: GO:0036394 ! amylase secretion +relationship: part_of GO:0030157 ! pancreatic juice secretion + +[Term] +id: GO:0036396 +name: RNA N6-methyladenosine methyltransferase complex +namespace: cellular_component +def: "A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B)." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715, PMID:24407421, PMID:29507755, PMID:29535189, PMID:29547716] +synonym: "m(6)A writer complex" RELATED [] +synonym: "m6A methyltransferase complex" RELATED [] +synonym: "METTL3-METTL14-WTAP methyltransferase complex" RELATED [] +synonym: "MIS complex" RELATED [] +synonym: "Mum2, Ime4, and Slz1 complex" EXACT [PMID:22685417] +synonym: "WMM complex" EXACT [] +is_a: GO:0034708 ! methyltransferase complex +is_a: GO:0045293 ! mRNA editing complex + +[Term] +id: GO:0036397 +name: formate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + a quinone = CO2 + a quinol." [GOC:bhm, RHEA:48592] +comment: Formerly EC:1.1.5.6. +synonym: "Fdh-N activity" RELATED [] +synonym: "formate dehydrogenase-N activity" RELATED [EC:1.17.5.3] +synonym: "formate:quinone oxidoreductase activity" RELATED [] +xref: EC:1.17.5.3 +xref: KEGG_REACTION:R09494 +xref: MetaCyc:FORMATEDEHYDROG-RXN +xref: RHEA:48592 +is_a: GO:0033695 ! oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor + +[Term] +id: GO:0036398 +name: TCR signalosome +namespace: cellular_component +def: "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology." [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112] +synonym: "LAT signalosome" EXACT [GOC:krc, PMID:17534068] +synonym: "linker for activation of T cells signalosome" EXACT [PMID:17534068] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0036399 +name: TCR signalosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome." [GOC:krc, PMID:22426112] +synonym: "LAT signalosome assembly" EXACT [GOC:krc, PMID:17534068] +synonym: "linker for activation of T cells signalosome assembly" EXACT [PMID:17534068] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0036400 +name: short neuropeptide F receptor activity +namespace: molecular_function +def: "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021] +comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. +synonym: "sNPF receptor activity" EXACT [PMID:12372405, PMID:21440021] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0036401 +name: pyrokinin receptor activity +namespace: molecular_function +def: "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060] +synonym: "PK receptor activity" EXACT [PMID:17065249] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0036402 +name: proteasome-activating activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818] +synonym: "ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:bf] +synonym: "proteasomal ATPase activity" EXACT [GOC:bf] +synonym: "proteasome channel gating activity" NARROW [GOC:rb] +synonym: "proteasome channel opening activity" NARROW [GOC:rb] +synonym: "proteasome-activating ATPase activity" EXACT [] +xref: EC:5.6.1.5 +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0036403 +name: arachidonate 8(S)-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [GOC:lb, PMID:10625675, RHEA:38675] +comment: This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677. +synonym: "8(S)-lipoxygenase activity" BROAD [GOC:bf] +synonym: "8-lipoxygenase (S-type)" BROAD [KEGG_REACTION:R07053] +xref: KEGG_REACTION:R07053 +xref: RHEA:38675 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0036404 +name: obsolete conversion of ds siRNA to ss siRNA +namespace: biological_process +def: "OBSOLETE. The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA)." [GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA" RELATED [GOC:bf] +is_obsolete: true +consider: GO:0004521 + +[Term] +id: GO:0036405 +name: anchored component of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:md] +synonym: "anchored to cell outer membrane" NARROW [] +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0031230 ! intrinsic component of cell outer membrane + +[Term] +id: GO:0036406 +name: anchored component of periplasmic side of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only." [GOC:dos, GOC:md] +synonym: "anchored to internal side of cell outer membrane" EXACT [] +synonym: "anchored to periplasmic side of cell outer membrane" NARROW [] +is_a: GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane +is_a: GO:0036405 ! anchored component of cell outer membrane + +[Term] +id: GO:0036407 +name: mycolate outer membrane +namespace: cellular_component +def: "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria)." [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661] +synonym: "MOM" EXACT [GOC:md] +synonym: "mycobacterial outer membrane" EXACT [GOC:md] +synonym: "mycomembrane" EXACT [GOC:das, GOC:md] +is_a: GO:0009279 ! cell outer membrane + +[Term] +id: GO:0036408 +name: histone acetyltransferase activity (H3-K14 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)." [GOC:vw, PMID:21289066] +synonym: "histone lysine N-acetyltransferase activity (H3-K14 specific)" EXACT [GOC:bf] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0036409 +name: histone H3-K14 acetyltransferase complex +namespace: cellular_component +def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3." [GOC:vw, PMID:21289066] +synonym: "H3-K14 histone acetyltransferase complex" EXACT [GOC:bf] +synonym: "histone acetyltransferase complex (H3-K14 specific)" EXACT [GOC:bf] +synonym: "histone H3 Lys 14 (H3K14) acetyltransferase complex" EXACT [PMID:21289066] +synonym: "histone H3K14 acetyltransferase complex" EXACT [PMID:21289066] +is_a: GO:0070775 ! H3 histone acetyltransferase complex + +[Term] +id: GO:0036410 +name: Mst2 histone acetyltransferase complex +namespace: cellular_component +def: "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6." [GOC:vw, PMID:21289066] +synonym: "Mst2 complex" EXACT [PMID:21289066] +synonym: "Mst2 H3K14 acetyltransferase complex" EXACT [PMID:21289066] +synonym: "Mst2 histone H3K14 acetyltransferase complex" EXACT [PMID:21289066] +is_a: GO:0036409 ! histone H3-K14 acetyltransferase complex + +[Term] +id: GO:0036411 +name: H-NS-Cnu complex +namespace: cellular_component +def: "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:18189420, PMID:22358512] +is_a: GO:0017053 ! transcription repressor complex + +[Term] +id: GO:0036412 +name: acetyl-CoA:oxalate CoA-transferase +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA." [GOC:imk, PMID:23935849] +xref: RHEA:37883 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0036413 +name: histone H3-R26 citrullination +namespace: biological_process +def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3." [GOC:als, PMID:22853951] +synonym: "histone H3 arginine 26 citrullination" EXACT [GOC:als] +is_a: GO:0036414 ! histone citrullination + +[Term] +id: GO:0036414 +name: histone citrullination +namespace: biological_process +def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein." [GOC:als, PMID:22853951, PMID:23175390] +synonym: "histone deimination" EXACT [Wikipedia:Citrullination] +is_a: GO:0016570 ! histone modification +is_a: GO:0018101 ! protein citrullination + +[Term] +id: GO:0036415 +name: regulation of tRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs." [GOC:aa, PMID:21502523, PMID:23572593] +is_a: GO:0043487 ! regulation of RNA stability +is_a: GO:1902370 ! regulation of tRNA catabolic process + +[Term] +id: GO:0036416 +name: tRNA stabilization +namespace: biological_process +def: "Prevention of degradation of tRNA molecules." [GOC:aa, GOC:bf, PMID:20459084] +is_a: GO:0036415 ! regulation of tRNA stability +is_a: GO:0043489 ! RNA stabilization +is_a: GO:1902371 ! negative regulation of tRNA catabolic process + +[Term] +id: GO:0036417 +name: tRNA destabilization +namespace: biological_process +def: "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes." [GOC:aa, GOC:bf] +is_a: GO:0036415 ! regulation of tRNA stability +is_a: GO:0050779 ! RNA destabilization +is_a: GO:1902372 ! positive regulation of tRNA catabolic process + +[Term] +id: GO:0036418 +name: intrinsic component of mycolate outer membrane +namespace: cellular_component +def: "The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:md] +synonym: "intrinsic to MOM" EXACT [GOC:md] +synonym: "intrinsic to mycolate outer membrane" NARROW [] +synonym: "intrinsic to mycomembrane" EXACT [GOC:das, GOC:md] +is_a: GO:0031230 ! intrinsic component of cell outer membrane +relationship: part_of GO:0036407 ! mycolate outer membrane + +[Term] +id: GO:0036419 +name: integral component of mycolate outer membrane +namespace: cellular_component +def: "The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:md] +synonym: "integral to MOM" EXACT [GOC:md] +synonym: "integral to mycolate outer membrane" NARROW [] +synonym: "integral to mycomembrane" EXACT [GOC:das, GOC:md] +is_a: GO:0036418 ! intrinsic component of mycolate outer membrane +is_a: GO:0045203 ! integral component of cell outer membrane + +[Term] +id: GO:0036420 +name: extrinsic component of mycolate outer membrane +namespace: cellular_component +def: "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:md] +synonym: "extrinsic to MOM" EXACT [GOC:md] +synonym: "extrinsic to mycolate outer membrane" NARROW [] +synonym: "extrinsic to mycomembrane" EXACT [GOC:das, GOC:md] +is_a: GO:0031244 ! extrinsic component of cell outer membrane +relationship: part_of GO:0036407 ! mycolate outer membrane + +[Term] +id: GO:0036421 +name: extrinsic component of external side of mycolate outer membrane +namespace: cellular_component +def: "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:md] +synonym: "extrinsic to external side of MOM" EXACT [GOC:md] +synonym: "extrinsic to external side of mycolate outer membrane" NARROW [] +synonym: "extrinsic to external side of mycomembrane" EXACT [GOC:das, GOC:md] +is_a: GO:0031242 ! extrinsic component of external side of cell outer membrane +is_a: GO:0036420 ! extrinsic component of mycolate outer membrane +relationship: part_of GO:0098568 ! external side of mycolate outer membrane + +[Term] +id: GO:0036422 +name: heptaprenyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [RHEA:27794] +synonym: "all-trans-heptaprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.30] +synonym: "HepPP synthase activity" RELATED [EC:2.5.1.30] +synonym: "heptaprenyl pyrophosphate synthase activity" RELATED [EC:2.5.1.30] +synonym: "heptaprenyl pyrophosphate synthetase activity" RELATED [EC:2.5.1.30] +xref: EC:2.5.1.30 +xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN +xref: RHEA:27794 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0036423 +name: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.83, RHEA:27559] +synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.83] +synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.83] +xref: EC:2.5.1.83 +xref: KEGG_REACTION:R09245 +xref: MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN +xref: RHEA:27559 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0036424 +name: L-phosphoserine phosphatase activity +namespace: molecular_function +alt_id: GO:0004647 +def: "Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid." [PMID:25037224, PMID:9188776, RHEA:21208] +comment: Do not confuse with protein phosphatases. For protein phosphatases, consider GO:0004722 ; protein serine/threonine phosphatase activity or GO:0008138 ; protein tyrosine/serine/threonine phosphatase activity. +synonym: "O-phosphoserine phosphohydrolase activity" RELATED [EC:3.1.3.3] +synonym: "phosphoserine phosphatase activity" RELATED [] +xref: EC:3.1.3.3 +xref: KEGG_REACTION:R00582 +xref: MetaCyc:PSERPHOSPHA-RXN +xref: MetaCyc:RXN0-5114 +xref: Reactome:R-HSA-977324 "PSPH:Mg2+ dimer dephosphorylates O-P-Ser" +xref: RHEA:21208 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0036425 +name: obsolete D-phosphoserine phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: O-phospho-D-serine + H2O = L-serine + phosphate, on a free amino acid." [GOC:curators] +comment: This term was obsoleted because there is no evidence that this function exisis. This reaction corresponds to RHEA:24873 and KEGG_REACTION:R02853. +is_obsolete: true +consider: GO:0036424 + +[Term] +id: GO:0036426 +name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [GOC:curators] +xref: KEGG_REACTION:R07257 +xref: MetaCyc:2.4.1.54-RXN +is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity + +[Term] +id: GO:0036427 +name: all-trans-undecaprenyl-phosphate mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:28118] +xref: RHEA:28118 +is_a: GO:0047267 ! undecaprenyl-phosphate mannosyltransferase activity + +[Term] +id: GO:0036428 +name: adenosylcobinamide kinase (GTP-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+." [RHEA:15765] +xref: KEGG_REACTION:R06558 +xref: MetaCyc:RXN-14063 +xref: RHEA:15765 +is_a: GO:0043752 ! adenosylcobinamide kinase activity + +[Term] +id: GO:0036429 +name: adenosylcobinamide kinase (ATP-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+." [RHEA:15769] +xref: KEGG_REACTION:R05221 +xref: MetaCyc:COBINAMIDEKIN-RXN +xref: RHEA:15769 +is_a: GO:0043752 ! adenosylcobinamide kinase activity + +[Term] +id: GO:0036430 +name: CMP kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CMP = ADP + CDP." [RHEA:11600] +xref: KEGG_REACTION:R00512 +xref: MetaCyc:RXN-11832 +xref: RHEA:11600 +is_a: GO:0004127 ! cytidylate kinase activity + +[Term] +id: GO:0036431 +name: dCMP kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dCMP = ADP + dCDP." [RHEA:25094] +synonym: "ATP:dCMP phosphotransferase activity" EXACT [KEGG_REACTION:R01665] +xref: KEGG_REACTION:R01665 +xref: MetaCyc:RXN-11831 +xref: MetaCyc:RXN-7913 +xref: RHEA:25094 +is_a: GO:0004127 ! cytidylate kinase activity + +[Term] +id: GO:0036432 +name: all-trans undecaprenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+." [RHEA:23752] +xref: RHEA:23752 +is_a: GO:0009038 ! undecaprenol kinase activity + +[Term] +id: GO:0036433 +name: di-trans, poly-cis-undecaprenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+." [RHEA:28122] +synonym: "ditrans,polycis-undecaprenol kinase activity" RELATED [] +xref: KEGG_REACTION:R05626 +xref: MetaCyc:UNDECAPRENOL-KINASE-RXN +xref: RHEA:28122 +is_a: GO:0009038 ! undecaprenol kinase activity + +[Term] +id: GO:0036434 +name: nitronate monooxygenase (FMN-linked) activity +namespace: molecular_function +def: "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite." [RHEA:26458] +xref: KEGG_REACTION:R00025 +xref: RHEA:26458 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0036435 +name: K48-linked polyubiquitin modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein." [GOC:al, PMID:20739285] +xref: Reactome:R-HSA-5683077 "RNF8 and RNF168 ubiquitinate KDM4A,B" +is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding + +[Term] +id: GO:0036436 +name: Isw1a complex +namespace: cellular_component +def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p." [GOC:jd, PMID:12482963] +is_a: GO:0016587 ! Isw1 complex + +[Term] +id: GO:0036437 +name: Isw1b complex +namespace: cellular_component +def: "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p." [GOC:jd, PMID:12482963] +is_a: GO:0016587 ! Isw1 complex + +[Term] +id: GO:0036438 +name: maintenance of lens transparency +namespace: biological_process +def: "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina." [GOC:nhn, PMID:22095752] +synonym: "maintenance of ocular lens transparency" EXACT [PMID:22095752] +synonym: "preservation of lens transparency" EXACT [PMID:22095752] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:0036440 +name: citrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [RHEA:16845] +xref: KEGG_REACTION:R00351 +xref: RHEA:16845 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0036441 +name: 2-dehydropantolactone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+." [RHEA:18981] +xref: KEGG_REACTION:R03155 +xref: RHEA:18981 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0036443 +name: dermatan 6-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate." [EC:2.8.2.33, GOC:bf, KEGG_REACTION:R07288] +xref: KEGG_REACTION:R07288 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0036444 +name: calcium import into the mitochondrion +namespace: biological_process +def: "A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix." [GOC:vw] +synonym: "calcium ion import into mitochondrion" BROAD [] +synonym: "calcium ion transmembrane import into mitochondrion" EXACT [] +synonym: "mitochondrial calcium ion import" BROAD [GOC:vw] +synonym: "mitochondrial calcium uptake" EXACT [] +is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport +is_a: GO:0060401 ! cytosolic calcium ion transport +is_a: GO:0070509 ! calcium ion import + +[Term] +id: GO:0036445 +name: neuronal stem cell division +namespace: biological_process +def: "The self-renewing division of a neuronal stem cell." [CL:0000047, GOC:nhn] +synonym: "NSC division" EXACT [CL:0000047] +is_a: GO:0048103 ! somatic stem cell division + +[Term] +id: GO:0036446 +name: myofibroblast differentiation +namespace: biological_process +def: "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn] +synonym: "myofibroblast cell differentiation" EXACT [CL:0000186] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0036447 +name: cellular response to sugar-phosphate stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate." [GOC:am, PMID:17383224] +synonym: "cellular response to presence of non-metabolizable sugars" RELATED [GOC:am] +is_a: GO:0062197 ! cellular response to chemical stress + +[Term] +id: GO:0036448 +name: cellular response to glucose-phosphate stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate." [GOC:am, PMID:17383224] +is_a: GO:0036447 ! cellular response to sugar-phosphate stress + +[Term] +id: GO:0036449 +name: microtubule minus-end +namespace: cellular_component +def: "The end of a microtubule that does not preferentially grow (polymerize)." [GOC:lb, PMID:23169647] +synonym: "microtubule minus end" EXACT [GOC:lb] +is_a: GO:1990752 ! microtubule end + +[Term] +id: GO:0036450 +name: polyuridylation-dependent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462] +synonym: "uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GOC:vw] +is_a: GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA +relationship: part_of GO:1990074 ! polyuridylation-dependent mRNA catabolic process + +[Term] +id: GO:0036451 +name: cap mRNA methylation +namespace: biological_process +def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA." [GOC:bf, PMID:20713356] +is_a: GO:0080009 ! mRNA methylation + +[Term] +id: GO:0036452 +name: ESCRT complex +namespace: cellular_component +def: "An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes." [PMID:16689637, VZ:1536] +synonym: "endosomal sorting complex required for transport" EXACT [PMID:22718754] +xref: Wikipedia:ESCRT +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0036453 +name: transitive RNA interference +namespace: biological_process +def: "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430] +synonym: "transitive RNAi" EXACT [PMID:12554873] +is_a: GO:0016246 ! RNA interference + +[Term] +id: GO:0036454 +name: growth factor complex +namespace: cellular_component +def: "A protein complex that has growth factor activity." [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0036455 +name: iron-sulfur transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)." [GOC:bhm] +synonym: "Fe-S transferase activity" EXACT [GOC:bf] +xref: Reactome:R-HSA-2564828 "CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins" +is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups + +[Term] +id: GO:0036456 +name: L-methionine-(S)-S-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O." [GOC:vw, RHEA:19995] +xref: RHEA:19995 +is_a: GO:0033744 ! L-methionine:thioredoxin-disulfide S-oxidoreductase activity + +[Term] +id: GO:0036457 +name: keratohyalin granule +namespace: cellular_component +def: "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0036458 +name: hepatocyte growth factor binding +namespace: molecular_function +def: "Binding to a hepatocyte growth factor." [GOC:curators] +synonym: "HGF binding" EXACT [PR:000008534] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0036460 +name: cellular response to cell envelope stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope." [GOC:imk, PMID:15101969, PMID:15882407] +synonym: "envelope stress response" EXACT [PMID:15882407] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0036461 +name: BLOC-2 complex binding +namespace: molecular_function +def: "Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules." [GOC:bf, GOC:PARL, PMID:22511774] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0036462 +name: TRAIL-activated apoptotic signaling pathway +namespace: biological_process +def: "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface." [GOC:bf, GOC:PARL, PMID:21785459] +synonym: "TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "TRAIL-induced apoptotic signaling pathway" EXACT [PMID:21785459] +synonym: "tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [PMID:21785459] +is_a: GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors + +[Term] +id: GO:0036463 +name: TRAIL receptor activity +namespace: molecular_function +def: "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." [GOC:bf, GOC:PARL] +synonym: "tumor necrosis factor-related apoptosis-inducing ligand receptor" EXACT [PMID:21785459] +is_a: GO:0005035 ! death receptor activity + +[Term] +id: GO:0036464 +name: cytoplasmic ribonucleoprotein granule +namespace: cellular_component +def: "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] +synonym: "Staufen granule" NARROW [PMID:15121898] +is_a: GO:0035770 ! ribonucleoprotein granule +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0036465 +name: synaptic vesicle recycling +namespace: biological_process +def: "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563] +synonym: "kiss-and-run synaptic vesicle recycling" NARROW [PMID:15217342] +synonym: "kiss-and-stay synaptic vesicle recycling" NARROW [PMID:15217342] +is_a: GO:0006810 ! transport +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0036466 +name: synaptic vesicle recycling via endosome +namespace: biological_process +alt_id: GO:0099090 +def: "Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:aruk, GOC:bc, GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342] +subset: goslim_synapse +synonym: "recycling endosome localization within postsynapse" EXACT [] +is_a: GO:0036465 ! synaptic vesicle recycling +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing + +[Term] +id: GO:0036467 +name: 5-hydroxy-L-tryptophan decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin." [GOC:bf, GOC:PARL, RHEA:18533] +synonym: "5-hydroxytryptophan decarboxylase activity" BROAD [EC:4.1.1.28] +xref: RHEA:18533 +is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity + +[Term] +id: GO:0036468 +name: L-dopa decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine." [GOC:bf, GOC:PARL, RHEA:12272] +synonym: "4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [PMID:19703902] +synonym: "DDC activity" EXACT [PMID:19703902] +synonym: "DOPA decarboxylase activity" RELATED [EC:4.1.1.28] +xref: RHEA:12272 +is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity + +[Term] +id: GO:0036469 +name: L-tryptophan decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine." [GOC:bf, GOC:PARL, RHEA:30339] +xref: EC:4.1.1.105 +xref: RHEA:30339 +is_a: GO:0004058 ! aromatic-L-amino-acid decarboxylase activity + +[Term] +id: GO:0036470 +name: tyrosine 3-monooxygenase activator activity +namespace: molecular_function +def: "Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity." [GOC:bf, GOC:PARL, PMID:19703902] +synonym: "TH activator activity" EXACT [PMID:19703902] +synonym: "tyrosine hydroxylase activator activity" EXACT [PMID:19703902] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0036471 +name: cellular response to glyoxal +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus." [GOC:bf, GOC:PARL] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0110096 ! cellular response to aldehyde + +[Term] +id: GO:0036472 +name: suppression by virus of host protein-protein interaction +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins." [GOC:bf, GOC:PARL, PMID:17297443] +synonym: "suppression by virus of host protein binding" EXACT [GOC:bf] +synonym: "suppression by virus of host protein interaction" EXACT [GOC:bf] +synonym: "suppression by virus of host protein:protein binding" EXACT [GOC:bf] +synonym: "suppression by virus of host protein:protein interaction" EXACT [GOC:bf] +is_a: GO:0039507 ! suppression by virus of host molecular function + +[Term] +id: GO:0036473 +name: cell death in response to oxidative stress +namespace: biological_process +def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred in response to an oxidative stress stimulus, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0097468 'programmed cell death in response to reactive oxygen species'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. +is_a: GO:0008219 ! cell death +relationship: part_of GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0036474 +name: cell death in response to hydrogen peroxide +namespace: biological_process +def: "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0010421 'hydrogen peroxide-mediated programmed cell death'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. +synonym: "cell death in response to H2O2" EXACT [GOC:bf] +synonym: "hydrogen peroxide-mediated cell death" RELATED [GOC:bf] +is_a: GO:0036473 ! cell death in response to oxidative stress +relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide + +[Term] +id: GO:0036475 +name: neuron death in response to oxidative stress +namespace: biological_process +def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. +synonym: "neuronal cell death in response to oxidative stress" EXACT [GOC:bf] +synonym: "oxidative stress-induced neuron death" EXACT [GOC:bf] +is_a: GO:0036473 ! cell death in response to oxidative stress +is_a: GO:0070997 ! neuron death + +[Term] +id: GO:0036476 +name: neuron death in response to hydrogen peroxide +namespace: biological_process +def: "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. +synonym: "hydrogen peroxide-induced neuron death" EXACT [GOC:bf] +synonym: "neuron death in response to H2O2" EXACT [GOC:bf] +synonym: "neuronal cell death in response to hydrogen peroxide" EXACT [GOC:bf] +is_a: GO:0036474 ! cell death in response to hydrogen peroxide +is_a: GO:0036475 ! neuron death in response to oxidative stress + +[Term] +id: GO:0036477 +name: somatodendritic compartment +namespace: cellular_component +def: "The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon." [GOC:pad, GOC:PARL] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0036478 +name: L-dopa decarboxylase activator activity +namespace: molecular_function +def: "Interacts with and increases L-dopa decarboxylase activity." [GOC:bf, GOC:PARL] +comment: GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'. +synonym: "DDC activator activity" EXACT [GOC:bf] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0036479 +name: peroxidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of peroxidase." [GOC:bf, GOC:PARL] +comment: GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'. +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0036480 +name: neuron intrinsic apoptotic signaling pathway in response to oxidative stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059] +synonym: "neuron apoptosis in response to oxidative stress" RELATED [GOC:bf] +synonym: "oxidative stress-induced neuron apoptosis" BROAD [GOC:bf] +synonym: "oxidative stress-induced neuronal apoptosis" BROAD [GOC:bf] +is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress +relationship: part_of GO:0036475 ! neuron death in response to oxidative stress +relationship: part_of GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0036481 +name: intrinsic apoptotic signaling pathway in response to hydrogen peroxide +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL] +synonym: "H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:bf] +synonym: "hydrogen peroxide-induced apoptosis" BROAD [GOC:bf] +synonym: "hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf] +is_a: GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress +relationship: part_of GO:0010421 ! hydrogen peroxide-mediated programmed cell death + +[Term] +id: GO:0036482 +name: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide." [GOC:bf, GOC:PARL] +synonym: "H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:bf] +synonym: "hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:bf] +synonym: "neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:bf] +synonym: "neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:bf] +is_a: GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress +is_a: GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide +relationship: part_of GO:0036476 ! neuron death in response to hydrogen peroxide + +[Term] +id: GO:0036483 +name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:bf, GOC:PARL, PMID:21113145] +synonym: "endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:bf] +synonym: "endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "ER stress-induced neuron apoptosis" BROAD [GOC:bf] +synonym: "ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +is_a: GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +relationship: part_of GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0036484 +name: trunk neural crest cell migration +namespace: biological_process +def: "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] +synonym: "trunk NCC migration" EXACT [PMID:2387238] +is_a: GO:0001755 ! neural crest cell migration +relationship: part_of GO:0035290 ! trunk segmentation + +[Term] +id: GO:0036485 +name: dorsolateral trunk neural crest cell migration +namespace: biological_process +def: "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238] +synonym: "dorsolateral trunk NCC migration" EXACT [PMID:2387238] +is_a: GO:0036484 ! trunk neural crest cell migration + +[Term] +id: GO:0036486 +name: ventral trunk neural crest cell migration +namespace: biological_process +def: "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta." [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662] +synonym: "trunk NCC migration through anterior sclerotome" EXACT [PMID:19386662] +synonym: "trunk NCC migration within somite" EXACT [GOC:mat] +synonym: "ventral trunk NCC migration" EXACT [GOC:bf] +is_a: GO:0036484 ! trunk neural crest cell migration + +[Term] +id: GO:0036487 +name: nitric-oxide synthase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of nitric oxide synthase." [GOC:BHF, GOC:rl, PMID:17242280] +synonym: "nitric oxide synthase inhibitor activity" EXACT [GOC:bf] +synonym: "NOS inhibitor activity" EXACT [GOC:bf] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0030235 ! nitric-oxide synthase regulator activity + +[Term] +id: GO:0036488 +name: CHOP-C/EBP complex +namespace: cellular_component +def: "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942] +synonym: "CHOP-C/EBP dimer" EXACT [PMID:8657121] +synonym: "CHOP-C/EBP heterodimer" EXACT [PMID:8657121] +synonym: "GADD153-C/EBP complex" EXACT [PMID:8657121] +synonym: "GADD153-C/EBP-alpha complex" NARROW [PMID:8657121] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0036489 +name: neuromelanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers." [GOC:bf, GOC:PARL, Wiki:Neuromelanin] +synonym: "neuromelanin anabolism" EXACT [GOC:bf] +synonym: "neuromelanin biosynthesis" EXACT [GOC:bf] +synonym: "neuromelanin formation" EXACT [GOC:bf] +synonym: "neuromelanin synthesis" EXACT [GOC:bf] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0036490 +name: regulation of translation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] +synonym: "regulation of translation in response to ER stress" EXACT [GOC:bf] +is_a: GO:0043555 ! regulation of translation in response to stress +relationship: part_of GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:0036491 +name: regulation of translation initiation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] +synonym: "regulation of translation initiation in response to ER stress" EXACT [GOC:bf] +is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0036492 +name: eiF2alpha phosphorylation in response to endoplasmic reticulum stress +namespace: biological_process +def: "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242] +synonym: "eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:bf] +synonym: "regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf] +is_a: GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation +is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress + +[Term] +id: GO:0036493 +name: positive regulation of translation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] +synonym: "positive regulation of translation in response to ER stress" EXACT [GOC:bf] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress + +[Term] +id: GO:0036494 +name: positive regulation of translation initiation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] +synonym: "positive regulation of translation initiation in response to ER stress" EXACT [GOC:bf] +is_a: GO:0032058 ! positive regulation of translational initiation in response to stress +is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress +is_a: GO:0036493 ! positive regulation of translation in response to endoplasmic reticulum stress + +[Term] +id: GO:0036495 +name: negative regulation of translation initiation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL] +synonym: "negative regulation of translation initiation in response to ER stress" RELATED [GOC:bf] +is_a: GO:0032057 ! negative regulation of translational initiation in response to stress +is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress +is_a: GO:1902010 ! negative regulation of translation in response to endoplasmic reticulum stress + +[Term] +id: GO:0036496 +name: regulation of translational initiation by eIF2 alpha dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha." [GOC:bf, GOC:PARL] +is_a: GO:0006470 ! protein dephosphorylation +is_a: GO:0032535 ! regulation of cellular component size +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0036497 +name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress +namespace: biological_process +def: "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:16835242] +synonym: "eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:bf] +synonym: "regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:bf] +is_a: GO:0036491 ! regulation of translation initiation in response to endoplasmic reticulum stress +is_a: GO:0036496 ! regulation of translational initiation by eIF2 alpha dephosphorylation + +[Term] +id: GO:0036498 +name: IRE1-mediated unfolded protein response +namespace: biological_process +def: "A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210] +comment: Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants. +synonym: "endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:bf] +synonym: "ERN1-mediated unfolded protein response" RELATED [HGNC:3449] +synonym: "inositol-requiring enzyme 1-mediated unfolded protein response" RELATED [HGNC:3449] +synonym: "inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [PMID:22013210] +synonym: "IRE1 branch of UPR" EXACT [GOC:bf] +synonym: "IRE1 signal transduction pathway" BROAD [GOC:bf] +synonym: "IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] +synonym: "IRE1alpha unfolded protein response" NARROW [PMID:22013210] +synonym: "IRE1p unfolded protein response" NARROW [PMID:22013210] +synonym: "UPR signaling by IRE1 stress sensor" EXACT [GOC:bf] +is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0036499 +name: PERK-mediated unfolded protein response +namespace: biological_process +def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210, PMID:27629041] +synonym: "EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] +synonym: "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:bf] +synonym: "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED [HGNC:3255] +synonym: "PERK branch of UPR" EXACT [GOC:bf] +synonym: "PERK signal transduction pathway" BROAD [GOC:bf] +synonym: "PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] +synonym: "PKR-like ER kinase signal transduction" EXACT [PMID:22013210] +synonym: "UPR signaling by PERK stress sensor" EXACT [GOC:bf] +is_a: GO:0006984 ! ER-nucleus signaling pathway +is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response +is_a: GO:0140467 ! integrated stress response signaling + +[Term] +id: GO:0036500 +name: ATF6-mediated unfolded protein response +namespace: biological_process +def: "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210] +synonym: "activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:bf] +synonym: "ATF6 branch of UPR" EXACT [GOC:bf] +synonym: "ATF6 signal transduction pathway" BROAD [GOC:bf] +synonym: "ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:bf] +synonym: "ATF6-alpha UPR branch" NARROW [GOC:bf] +synonym: "ATF6-beta UPR branch" NARROW [GOC:bf] +synonym: "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:bf] +synonym: "UPR signaling by ATF6 stress sensor" EXACT [GOC:bf] +is_a: GO:0006984 ! ER-nucleus signaling pathway +is_a: GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:0036501 +name: UFD1-NPL4 complex +namespace: cellular_component +def: "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p." [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586] +synonym: "Npl4p-Ufd1p complex" EXACT [PMID:17289586] +synonym: "Ufd1-Npl4 binary complex" EXACT [PMID:10811609] +synonym: "Ufd1-Npl4 cofactor complex" EXACT [PMID:10811609] +synonym: "Ufd1/Npl4 complex" EXACT [PMID:10811609] +synonym: "UFD1L-NPLOC4 complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0036502 +name: Derlin-1-VIMP complex +namespace: cellular_component +def: "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510] +synonym: "Derlin-1/VIMP complex" EXACT [PMID:15215856] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0036503 +name: ERAD pathway +namespace: biological_process +def: "The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL, PMID:20940304, PMID:21969857] +comment: ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct. +synonym: "endoplasmic reticulum-associated degradation" EXACT [PMID:22535891] +synonym: "endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:bf] +synonym: "ER-associated degradation pathway" RELATED [PMID:24699081] +synonym: "protein degradation by ERAD" EXACT [GOC:bf] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0010498 ! proteasomal protein catabolic process +is_a: GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:0036504 +name: Golgi membrane fusion +namespace: biological_process +def: "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691] +synonym: "membrane fusion involved in Golgi reassembly" EXACT [GOC:bf] +synonym: "post-mitotic fusion of Golgi membranes" EXACT [PMID:10811609] +is_a: GO:0090174 ! organelle membrane fusion +relationship: part_of GO:0090168 ! Golgi reassembly + +[Term] +id: GO:0036505 +name: prosaposin receptor activity +namespace: molecular_function +def: "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493] +synonym: "prosaposin-activated receptor activity" EXACT [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0036506 +name: maintenance of unfolded protein +namespace: biological_process +def: "Maintaining a protein in an unfolded, soluble state." [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303] +is_a: GO:0031647 ! regulation of protein stability + +[Term] +id: GO:0036507 +name: protein demannosylation +namespace: biological_process +def: "The removal of one or more mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:25092655] +comment: Consider also annotating to the term 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "protein de-mannosylation" EXACT [GOC:bf] +is_a: GO:0006517 ! protein deglycosylation + +[Term] +id: GO:0036508 +name: protein alpha-1,2-demannosylation +namespace: biological_process +def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655] +comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "glycoprotein mannose trimming" RELATED [GOC:bf] +synonym: "mannose trimming" BROAD [PMID:21062743] +is_a: GO:0036507 ! protein demannosylation + +[Term] +id: GO:0036509 +name: trimming of terminal mannose on B branch +namespace: biological_process +def: "The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, KEGG_REACTION:R06722, PMID:22160784] +comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2" RELATED [PMID:22160784] +synonym: "conversion of M9 to M8B" RELATED [PMID:25092655] +synonym: "glycoprotein mannose trimming on B branch" EXACT [GOC:bf] +xref: KEGG_REACTION:R06722 +is_a: GO:1904380 ! endoplasmic reticulum mannose trimming + +[Term] +id: GO:0036510 +name: trimming of terminal mannose on C branch +namespace: biological_process +def: "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:20065073] +comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2" RELATED [PMID:20065073] +synonym: "conversion of M9 to M8C" RELATED [GOC:bf] +synonym: "glycoprotein mannose trimming on C branch" EXACT [GOC:bf] +is_a: GO:1904380 ! endoplasmic reticulum mannose trimming + +[Term] +id: GO:0036511 +name: trimming of first mannose on A branch +namespace: biological_process +def: "The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701] +comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2" RELATED [GOC:bf] +synonym: "conversion of M9 to M8A" RELATED [GOC:bf] +synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf] +is_a: GO:1904380 ! endoplasmic reticulum mannose trimming + +[Term] +id: GO:0036512 +name: trimming of second mannose on A branch +namespace: biological_process +def: "The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701] +comment: Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. +synonym: "conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2" RELATED [GOC:bf] +synonym: "conversion of M8A to M7AA" RELATED [GOC:bf] +synonym: "glycoprotein mannose trimming on A branch" BROAD [GOC:bf] +is_a: GO:1904380 ! endoplasmic reticulum mannose trimming + +[Term] +id: GO:0036513 +name: Derlin-1 retrotranslocation complex +namespace: cellular_component +def: "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510] +comment: The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process. +synonym: "Derlin-1 complex" EXACT [PMID:18555783] +synonym: "Derlin-1 protein dislocation complex" EXACT [PMID:18555783] +synonym: "Derlin-1 retro-translocation complex" EXACT [GOC:bf] +synonym: "Derlin-1 retrotranslocon" EXACT [GOC:bf] +synonym: "ERAD protein dislocation complex" EXACT [PMID:18555783] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0036514 +name: dopaminergic neuron axon guidance +namespace: biological_process +def: "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308] +synonym: "DA axon guidance" EXACT [PMID:23517308] +synonym: "dopaminergic axon guidance" EXACT [GOC:bf] +synonym: "mdDA axon guidance" EXACT [PMID:21106844] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0036515 +name: serotonergic neuron axon guidance +namespace: biological_process +def: "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] +synonym: "5-HT axon guidance" EXACT [GOC:bf, PMID:21106844] +synonym: "serotonergic axon guidance" EXACT [GOC:bf] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0036516 +name: chemoattraction of dopaminergic neuron axon +namespace: biological_process +def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:bf, GOC:PARL, PMID:21106844] +synonym: "chemoattraction of DA axon" EXACT [GOC:bf] +synonym: "chemoattraction of dopaminergic axon" EXACT [GOC:bf] +is_a: GO:0061642 ! chemoattraction of axon +relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance + +[Term] +id: GO:0036517 +name: chemoattraction of serotonergic neuron axon +namespace: biological_process +def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] +synonym: "chemoattraction of 5-HT axon" EXACT [GOC:bf, PMID:21106844] +synonym: "chemoattraction of serotonergic axon" EXACT [GOC:bf] +is_a: GO:0061642 ! chemoattraction of axon +relationship: part_of GO:0036515 ! serotonergic neuron axon guidance + +[Term] +id: GO:0036518 +name: chemorepulsion of dopaminergic neuron axon +namespace: biological_process +def: "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308] +synonym: "chemorepulsion of DA axon" EXACT [GOC:bf, PMID:23517308] +synonym: "chemorepulsion of dopaminergic axon" RELATED [GOC:bf] +is_a: GO:0061643 ! chemorepulsion of axon +relationship: part_of GO:0036514 ! dopaminergic neuron axon guidance + +[Term] +id: GO:0036519 +name: chemorepulsion of serotonergic neuron axon +namespace: biological_process +def: "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844] +synonym: "chemorepulsion of 5-HT axon" EXACT [GOC:bf, PMID:21106844] +synonym: "chemorepulsion of serotonergic axon" RELATED [GOC:bf] +is_a: GO:0061643 ! chemorepulsion of axon +relationship: part_of GO:0036515 ! serotonergic neuron axon guidance + +[Term] +id: GO:0036520 +name: astrocyte-dopaminergic neuron signaling +namespace: biological_process +def: "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258] +synonym: "astrocyte-dopaminergic neuron cell signaling" EXACT [GOC:bf] +synonym: "dopaminergic neuron-astrocyte crosstalk" RELATED [PMID:21752258] +synonym: "mesencephalic dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] +synonym: "midbrain dopaminergic neuron-astrocyte crosstalk" NARROW [PMID:21752258] +is_a: GO:0150098 ! glial cell-neuron signaling + +[Term] +id: GO:0036521 +name: modulation by symbiont of host protein localization to phagocytic vesicle +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] +synonym: "modulation by symbiont of host protein localisation to phagosome" RELATED [GOC:bf] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle + +[Term] +id: GO:0036522 +name: negative regulation by symbiont of host protein localization to phagocytic vesicle +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] +synonym: "disruption of host protein localisation to phagosome" EXACT [GOC:bf] +synonym: "inhibition of host protein localisation to phagosome" EXACT [GOC:bf] +synonym: "suppression of host protein localisation to phagosome" EXACT [GOC:bf] +is_a: GO:0036521 ! modulation by symbiont of host protein localization to phagocytic vesicle +is_a: GO:1905170 ! negative regulation of protein localization to phagocytic vesicle + +[Term] +id: GO:0036523 +name: obsolete induction by symbiont of host cytokine production +namespace: biological_process +def: "OBSOLETE. Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:PARL, PMID:25063865] +comment: This term was obsoleted because it does not represent a real process. +synonym: "'induction by symbiont of host cytokine secretion'" NARROW [] +synonym: "induction by symbiont of host cytokine secretion" RELATED [PMID:25063865] +synonym: "positive regulation by symbiont of host cytokine secretion" NARROW [] +is_obsolete: true + +[Term] +id: GO:0036524 +name: protein deglycase activity +namespace: molecular_function +def: "Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785, PMID:26873906] +synonym: "protein deglycating enzyme" RELATED [PMID:26873906] +xref: MetaCyc:RXN-17630 +xref: MetaCyc:RXN-17632 +xref: MetaCyc:RXN-17634 +is_a: GO:0016836 ! hydro-lyase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0036525 +name: protein deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] +comment: Glycation is a non enzymatic covalent addition of a sugar or dicarbonyl (methylglyoxal, glyoxal) to a protein. Deglycation repairs the glycated amino acids. +synonym: "glycated protein repair" RELATED [PMID:25416785] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0030091 ! protein repair + +[Term] +id: GO:0036526 +name: peptidyl-cysteine deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] +synonym: "deglycation of N-acetylcysteine" RELATED [PMID:25416785] +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0036525 ! protein deglycation + +[Term] +id: GO:0036527 +name: peptidyl-arginine deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] +synonym: "deglycation of N-acetylarginine" RELATED [PMID:25416785] +is_a: GO:0018195 ! peptidyl-arginine modification +is_a: GO:0036525 ! protein deglycation + +[Term] +id: GO:0036528 +name: peptidyl-lysine deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein." [GOC:bf, GOC:PARL, PMID:14568004, PMID:25416785] +synonym: "deglycation of N-acetyllysine" RELATED [PMID:25416785] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0036525 ! protein deglycation + +[Term] +id: GO:0036529 +name: protein deglycation, glyoxal removal +namespace: biological_process +def: "The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785] +synonym: "protein deglycation of glyoxal-glycated protein" RELATED [PMID:25416785] +is_a: GO:0036525 ! protein deglycation +is_a: GO:0046295 ! glycolate biosynthetic process +is_a: GO:1903189 ! glyoxal metabolic process + +[Term] +id: GO:0036530 +name: protein deglycation, methylglyoxal removal +namespace: biological_process +def: "The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein." [GOC:bf, GOC:PARL, PMID:25416785] +synonym: "protein deglycation of methylglyoxal-glycated protein" RELATED [PMID:25416785] +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0019249 ! lactate biosynthetic process +is_a: GO:0036525 ! protein deglycation + +[Term] +id: GO:0036531 +name: glutathione deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine." [GOC:bf, GOC:PARL, PMID:25416785] +is_a: GO:0006749 ! glutathione metabolic process + +[Term] +id: GO:0038001 +name: paracrine signaling +namespace: biological_process +def: "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782] +comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling. +synonym: "paracrine signalling" EXACT [GOC:bf] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0038002 +name: endocrine signaling +namespace: biological_process +def: "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782] +comment: This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling. +synonym: "endocrine signalling" EXACT [GOC:bf] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0050886 ! endocrine process + +[Term] +id: GO:0038003 +name: G protein-coupled opioid receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands." [GOC:bf, PMID:20494127] +synonym: "opioid receptor signaling pathway" BROAD [] +synonym: "opioid receptor signalling pathway" EXACT [GOC:mah] +xref: Wikipedia:Opioid_receptor +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038004 +name: epidermal growth factor receptor ligand maturation +namespace: biological_process +alt_id: GO:0038005 +def: "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524, PMID:11672525] +synonym: "EGFR ligand maturation" EXACT [GOC:bf] +synonym: "EGFR ligand maturation by peptide bond cleavage" NARROW [GOC:bf] +synonym: "EGFR ligand processing" NARROW [GOC:bf] +synonym: "epidermal growth factor receptor ligand processing" RELATED [GOC:bf] +synonym: "peptide bond cleavage involved in EGFR ligand maturation" NARROW [GOC:bf] +synonym: "peptide bond cleavage involved in epidermal growth factor receptor ligand maturation" RELATED [] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0038006 +name: netrin receptor activity involved in chemoattraction +namespace: molecular_function +def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin." [GOC:signaling] +synonym: "attractive netrin receptor activity" EXACT [GOC:bf] +synonym: "netrin receptor activity involved in positive chemotaxis" EXACT [GOC:bf] +is_a: GO:0005042 ! netrin receptor activity + +[Term] +id: GO:0038007 +name: netrin-activated signaling pathway +namespace: biological_process +def: "A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323] +synonym: "netrin signaling pathway" EXACT [GOC:bf] +synonym: "netrin-activated signal transduction pathway" EXACT [GOC:bf] +synonym: "netrin-activated signalling pathway" EXACT [GOC:bf] +synonym: "netrin-mediated signaling pathway" EXACT [GOC:bf] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038008 +name: TRAF-mediated signal transduction +namespace: biological_process +def: "The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components." [GOC:bf, PMID:19918944, PMID:20596822] +synonym: "TRAF signaling" EXACT [GOC:bf] +synonym: "TRAF-mediated intracellular signaling" EXACT [GOC:bf] +synonym: "TRAF-mediated signaling" EXACT [GOC:bf] +synonym: "TRAF-mediated signalling" EXACT [GOC:bf] +synonym: "tumor necrosis factor receptor-associated factor signal transduction" EXACT [GOC:bf] +synonym: "tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0038009 +name: regulation of signal transduction by receptor internalization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway." [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798] +synonym: "regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0031623 ! receptor internalization + +[Term] +id: GO:0038010 +name: positive regulation of signal transduction by receptor internalization +namespace: biological_process +def: "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798] +synonym: "positive regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0038009 ! regulation of signal transduction by receptor internalization + +[Term] +id: GO:0038011 +name: negative regulation of signal transduction by receptor internalization +namespace: biological_process +def: "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798] +synonym: "negative regulation of signaling pathway by receptor endocytosis" EXACT [GOC:bf] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0038009 ! regulation of signal transduction by receptor internalization + +[Term] +id: GO:0038012 +name: negative regulation of Wnt signaling pathway by Wnt receptor internalization +namespace: biological_process +def: "Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction." [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732] +synonym: "ligand-dependent internalization of Frizzled" NARROW [PMID:19643732] +synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor endocytosis" NARROW [GOC:bf] +synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway by Wnt receptor internalization" EXACT [GOC:mah] +synonym: "negative regulation of Wnt-activated signaling pathway by Wnt receptor internalization" EXACT [GOC:signaling] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization +is_a: GO:0038017 ! Wnt receptor internalization + +[Term] +id: GO:0038013 +name: positive regulation of Wnt signaling pathway by Wnt receptor internalization +namespace: biological_process +def: "Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway." [GOC:bf, GOC:signaling, PMID:17908284] +synonym: "positive regulation of Wnt receptor signaling pathway by Frizzled internalization" RELATED [] +synonym: "positive regulation of Wnt receptor signaling pathway by LRP6 internalization" NARROW [GOC:bf] +synonym: "positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway by Wnt receptor endocytosis" EXACT [GOC:bf] +synonym: "positive regulation of Wnt-activated signaling pathway by Wnt receptor internalization" RELATED [GOC:signaling] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization +is_a: GO:0038017 ! Wnt receptor internalization + +[Term] +id: GO:0038014 +name: negative regulation of insulin receptor signaling pathway by insulin receptor internalization +namespace: biological_process +def: "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation." [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114] +synonym: "agonist-stimulated insulin receptor internalization" BROAD [PMID:18492485] +synonym: "negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah] +is_a: GO:0038011 ! negative regulation of signal transduction by receptor internalization +is_a: GO:0038016 ! insulin receptor internalization +is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway + +[Term] +id: GO:0038015 +name: positive regulation of insulin receptor signaling pathway by insulin receptor internalization +namespace: biological_process +def: "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane." [GOC:bf, GOC:signaling, PMID:9609114] +synonym: "positive regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT [GOC:mah] +is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization +is_a: GO:0038016 ! insulin receptor internalization +is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway + +[Term] +id: GO:0038016 +name: insulin receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:3907718, PMID:9609114] +synonym: "insulin receptor endocytosis" BROAD [GOC:bf] +is_a: GO:0031623 ! receptor internalization + +[Term] +id: GO:0038017 +name: Wnt receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:17908284] +synonym: "Wnt receptor endocytosis" BROAD [GOC:bf] +is_a: GO:0031623 ! receptor internalization + +[Term] +id: GO:0038018 +name: Wnt receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732] +synonym: "Frizzled degradation" NARROW [PMID:19643732] +synonym: "negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation" EXACT [GOC:bf] +synonym: "Wnt receptor breakdown" EXACT [GOC:bf] +synonym: "Wnt receptor catabolism" EXACT [GOC:bf] +synonym: "Wnt receptor degradation" RELATED [GOC:bf] +is_a: GO:0032801 ! receptor catabolic process +relationship: part_of GO:0030178 ! negative regulation of Wnt signaling pathway + +[Term] +id: GO:0038019 +name: Wnt receptor recycling +namespace: biological_process +def: "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:19643732] +synonym: "Frizzled recycling" NARROW [PMID:19643732] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0030177 ! positive regulation of Wnt signaling pathway + +[Term] +id: GO:0038020 +name: insulin receptor recycling +namespace: biological_process +def: "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:3907718] +is_a: GO:0001881 ! receptor recycling +relationship: part_of GO:0046628 ! positive regulation of insulin receptor signaling pathway + +[Term] +id: GO:0038021 +name: leptin receptor activity +namespace: molecular_function +def: "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0038022 +name: G protein-coupled olfactory receptor activity +namespace: molecular_function +def: "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:sart, PMID:21041441] +synonym: "G-protein coupled odorant receptor activity" EXACT [GOC:bf, PMID:21041441] +synonym: "G-protein coupled olfactory receptor activity" EXACT [] +synonym: "odorant receptor activity, G-protein coupled" NARROW [GOC:bf, PMID:21041441] +synonym: "olfactory receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0004984 ! olfactory receptor activity + +[Term] +id: GO:0038023 +name: signaling receptor activity +namespace: molecular_function +alt_id: GO:0004872 +alt_id: GO:0019041 +def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +subset: goslim_mouse +subset: goslim_pir +subset: goslim_plant +synonym: "receptor activity" BROAD [] +synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] +synonym: "signalling receptor activity" EXACT [] +is_a: GO:0060089 ! molecular transducer activity + +[Term] +id: GO:0038024 +name: cargo receptor activity +namespace: molecular_function +def: "Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles." [PMID:15239958, PMID:27903609] +comment: Notes: (1) this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857. +subset: goslim_drosophila +subset: goslim_generic +synonym: "endocytic receptor activity" NARROW [GOC:signaling, ISBN:0123645387, PMID:12671190] +synonym: "receptor activity" BROAD [] +synonym: "receptor activity involved in receptor-mediated endocytosis" NARROW [GOC:bf] +synonym: "transport receptor activity" BROAD [GOC:signaling] +xref: Reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome" +xref: Reactome:R-HSA-350168 "LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D" +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0038025 +name: reelin receptor activity +namespace: molecular_function +def: "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215] +synonym: "reeler receptor activity" EXACT [PR:000013879] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0038026 +name: reelin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215] +synonym: "reeler-mediated signaling pathway" EXACT [GOC:bf, PR:000013879] +synonym: "reelin-mediated signal transduction pathway" EXACT [GOC:bf] +synonym: "reelin-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038027 +name: apolipoprotein A-I-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:16443932] +synonym: "apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038028 +name: insulin receptor signaling pathway via phosphatidylinositol 3-kinase +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade." [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212] +synonym: "insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade" RELATED [] +synonym: "insulin receptor signaling pathway via PI3K cascade" EXACT [GOC:bf] +synonym: "insulin receptor signaling via PI3K" EXACT [GOC:bf] +synonym: "insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade" EXACT [GOC:mah] +is_a: GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0038029 +name: epidermal growth factor receptor signaling pathway via MAPK cascade +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade." [GOC:bf, GOC:signaling, PMID:21167805] +synonym: "EGFR signaling pathway via MAPKKK cascade" EXACT [GOC:bf] +synonym: "EGFR signaling via MAPKKK cascade" EXACT [GOC:bf] +synonym: "EGFR/MAPK signaling" EXACT [GOC:bf] +synonym: "epidermal growth factor receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] +synonym: "epidermal growth factor receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0038030 +name: non-canonical Wnt signaling pathway via MAPK cascade +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade." [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811] +synonym: "non-canonical Wnt receptor signaling pathway via MAPK cascade" EXACT [] +synonym: "non-canonical Wnt receptor signaling pathway via MAPK signaling" EXACT [GOC:bf] +synonym: "non-canonical Wnt receptor signaling pathway via MAPKKK cascade" EXACT [GOC:signaling] +synonym: "non-canonical Wnt receptor signalling pathway via MAPKKK cascade" EXACT [GOC:bf] +synonym: "non-canonical Wnt-activated signaling pathway via MAPK cascade" EXACT [GOC:signaling] +is_a: GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:0038031 +name: non-canonical Wnt signaling pathway via JNK cascade +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade." [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469] +synonym: "non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] +synonym: "non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:bf] +synonym: "non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] +is_a: GO:0038030 ! non-canonical Wnt signaling pathway via MAPK cascade + +[Term] +id: GO:0038032 +name: termination of G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling] +synonym: "termination of G-protein coupled receptor signaling pathway" EXACT [] +synonym: "termination of G-protein coupled receptor signalling pathway" EXACT [GOC:mah] +synonym: "termination of GPCR signaling pathway" EXACT [GOC:bf] +is_a: GO:0023021 ! termination of signal transduction +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038033 +name: positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381] +synonym: "positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway" EXACT [GOC:bf] +synonym: "vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis" RELATED [GOC:bf] +synonym: "VEGF-mediated chemotactic endothelial cell migration" BROAD [GOC:bf, PMID:21245381] +synonym: "VEGF-VEGFR-induced endothelial cell chemotaxis" EXACT [GOC:bf] +is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway +is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway +is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis + +[Term] +id: GO:0038034 +name: signal transduction in absence of ligand +namespace: biological_process +def: "A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679] +synonym: "addiction receptor signaling pathway" BROAD [PMID:15044679] +synonym: "basal signaling" NARROW [GOC:al] +synonym: "dependence receptor signaling pathway" BROAD [PMID:15044679] +synonym: "negative signal transduction" RELATED [PMID:15044679] +synonym: "non-classical signal transduction" BROAD [PMID:15044679] +synonym: "signal transduction in absence of agonist" EXACT [GOC:bf] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0038035 +name: G protein-coupled receptor signaling in absence of ligand +namespace: biological_process +def: "A series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist." [GOC:al, PMID:12402500, PMID:17629961] +comment: This term is intended for use by G protein-coupled receptors which signal at a low-level in the absence of agonist binding. +synonym: "basal G-protein coupled receptor signaling" NARROW [GOC:al] +synonym: "G-protein coupled receptor signaling in absence of agonist" EXACT [GOC:bf] +synonym: "G-protein coupled receptor signaling in absence of ligand" EXACT [] +synonym: "G-protein coupled receptor signalling in absence of ligand" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0038034 ! signal transduction in absence of ligand + +[Term] +id: GO:0038036 +name: sphingosine-1-phosphate receptor activity +namespace: molecular_function +def: "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, PMID:12728273, Wikipedia:S1PR1] +synonym: "S1P receptor activity" EXACT [Wikipedia:Sphingosine_1-phosphate] +is_a: GO:0045125 ! bioactive lipid receptor activity + +[Term] +id: GO:0038037 +name: G protein-coupled receptor dimeric complex +namespace: cellular_component +def: "A protein complex that contains two G protein-coupled receptors." [GOC:al, GOC:bf, PMID:10713101] +synonym: "G-protein coupled receptor dimer" EXACT [GOC:bf] +synonym: "G-protein coupled receptor dimeric complex" EXACT [] +synonym: "GPCR dimer" EXACT [GOC:bf] +is_a: GO:0097648 ! G protein-coupled receptor complex + +[Term] +id: GO:0038038 +name: G protein-coupled receptor homodimeric complex +namespace: cellular_component +def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor." [GOC:al, GOC:bf, PMID:10713101, PMID:16670762] +synonym: "G-protein coupled receptor homodimer" EXACT [GOC:bf] +synonym: "G-protein coupled receptor homodimeric complex" EXACT [] +synonym: "GPCR homodimer" EXACT [GOC:bf] +is_a: GO:0038037 ! G protein-coupled receptor dimeric complex + +[Term] +id: GO:0038039 +name: G protein-coupled receptor heterodimeric complex +namespace: cellular_component +def: "A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590] +synonym: "G-protein coupled receptor heterodimer" EXACT [GOC:bf] +synonym: "G-protein coupled receptor heterodimeric complex" EXACT [] +synonym: "GPCR heterodimer" EXACT [PMID:20150590] +is_a: GO:0038037 ! G protein-coupled receptor dimeric complex + +[Term] +id: GO:0038040 +name: obsolete cross-receptor activation within G-protein coupled receptor heterodimer +namespace: biological_process +def: "OBSOLETE. Activation of one protomer of a consequence of a G protein-coupled (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter." [GOC:al, GOC:bf, PMID:21063387] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0038041 +name: cross-receptor inhibition within G protein-coupled receptor heterodimer +namespace: biological_process +def: "Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit." [GOC:al, GOC:bf, PMID:15979374] +synonym: "cross-receptor inhibition within G-protein coupled receptor heterodimer" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0038043 +name: interleukin-5-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling] +synonym: "IL-5-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-5-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038045 +name: large latent transforming growth factor-beta complex +namespace: cellular_component +def: "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors." [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445, Reactome:R-HSA-177107] +synonym: "large latent complex" EXACT [Reactome:R-HSA-177107] +synonym: "LLC" EXACT [Reactome:R-HSA-177107] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0038046 +name: G protein-coupled enkephalin receptor activity +namespace: molecular_function +def: "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body." [GOC:bf, Wikipedia:Enkephalin] +synonym: "delta-opioid receptor activity" RELATED [GOC:bf] +synonym: "enkephalin receptor activity" BROAD [] +is_a: GO:0004985 ! G protein-coupled opioid receptor activity + +[Term] +id: GO:0038047 +name: morphine receptor activity +namespace: molecular_function +def: "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf] +synonym: "mu-opioid receptor activity" RELATED [GOC:bf] +is_a: GO:0004985 ! G protein-coupled opioid receptor activity + +[Term] +id: GO:0038048 +name: dynorphin receptor activity +namespace: molecular_function +def: "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin." [GOC:bf, Wikipedia:Dynorphin] +synonym: "kappa-opioid receptor activity" RELATED [GOC:bf] +is_a: GO:0004985 ! G protein-coupled opioid receptor activity + +[Term] +id: GO:0038053 +name: obsolete transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Combining with estrogen and transmitting the signal to the transcriptional machinery by binding to an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements." [GOC:signaling, PMID:17615392] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "estrogen nuclear receptor activity" BROAD [GOC:bf] +synonym: "estrogen-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0038054 +name: G protein-coupled estrogen receptor activity +namespace: molecular_function +def: "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:signaling, PMID:17379646, PMID:20960099] +synonym: "G-protein coupled estrogen receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0030284 ! estrogen receptor activity + +[Term] +id: GO:0038055 +name: BMP secretion +namespace: biological_process +def: "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart] +synonym: "BMP protein secretion" EXACT [GOC:bf] +synonym: "bone morphogenetic protein secretion" EXACT [GOC:bf] +is_a: GO:0009306 ! protein secretion +is_a: GO:0023061 ! signal release + +[Term] +id: GO:0038056 +name: negative regulation of BMP signaling pathway by negative regulation of BMP secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell." [GOC:bf, GOC:sart, PMID:21750037] +synonym: "negative regulation of BMP signaling pathway by negative regulation of bone morphogenetic protein secretion" EXACT [GOC:bf] +synonym: "negative regulation of BMP signalling pathway by negative regulation of BMP secretion" EXACT [GOC:bf] +is_a: GO:0030514 ! negative regulation of BMP signaling pathway +is_a: GO:2001285 ! negative regulation of BMP secretion + +[Term] +id: GO:0038057 +name: TNFSF11 binding +namespace: molecular_function +def: "Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm] +synonym: "CD254 binding" EXACT [GOC:sl, PR:000002107] +synonym: "ODF binding" EXACT [GOC:sl, PR:000002107] +synonym: "OPGL binding" EXACT [GOC:sl, PR:000002107] +synonym: "osteoclast differentiation factor binding" EXACT [GOC:sl, PR:000002107] +synonym: "osteoprotegerin ligand binding" EXACT [GOC:sl, PR:000002107] +synonym: "RANKL binding" EXACT [GOC:sl, PR:000002107] +synonym: "receptor activator of nuclear factor kappa-B ligand binding" EXACT [GOC:sl, PR:000002107] +synonym: "TNF-related activation-induced cytokine binding" EXACT [GOC:sl, PR:000002107] +synonym: "TRANCE binding" EXACT [GOC:sl, PR:000002107] +synonym: "tumor necrosis factor (ligand) superfamily member 11 binding" EXACT [GOC:bf] +synonym: "tumor necrosis factor ligand superfamily member 11 binding" EXACT [PR:000002107] +synonym: "tumor necrosis factor superfamily member 11 binding" EXACT [GOC:bf] +is_a: GO:0043120 ! tumor necrosis factor binding + +[Term] +id: GO:0038058 +name: TNFSF11 receptor activity +namespace: molecular_function +def: "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm] +synonym: "RANKL receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] +synonym: "tumor necrosis factor ligand superfamily member 11 receptor activity" EXACT [PR:000002107, Wikipedia:RANKL] +is_a: GO:0005031 ! tumor necrosis factor-activated receptor activity + +[Term] +id: GO:0038059 +name: IKKalpha-IKKalpha complex +namespace: cellular_component +def: "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits." [GOC:bf, PMID:18626576, PMID:21173796] +synonym: "IkappaB kinase alpha homodimer" EXACT [GOC:bf] +synonym: "IkappaB kinase-alpha homodimer" EXACT [PMID:21173796] +synonym: "IKKalpha homodimer" EXACT [GOC:bf] +synonym: "IKKalpha homodimeric complex" EXACT [GOC:bf] +synonym: "IKKalpha-IKKalpha protein complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0038060 +name: nitric oxide-cGMP-mediated signaling pathway +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632] +synonym: "canonical nitric oxide signaling" EXACT [GOC:bf] +synonym: "classical nitric oxide signaling" EXACT [PMID:21549190] +synonym: "nitric oxide-cGMP-mediated signalling pathway" EXACT [GOC:mah] +synonym: "NO-cGMP signaling pathway" EXACT [PMID:22019632] +is_a: GO:0007263 ! nitric oxide mediated signal transduction +is_a: GO:0019934 ! cGMP-mediated signaling + +[Term] +id: GO:0038061 +name: NIK/NF-kappaB signaling +namespace: biological_process +def: "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882] +synonym: "NIK/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "NIK/NF-kappaB signal transduction" EXACT [GOC:signaling] +synonym: "non-canonical NF-KB signaling" BROAD [PMID:21173796] +synonym: "noncanonical NF-kappaB signaling" BROAD [PMID:20501935] +synonym: "noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [PMID:20501935] +synonym: "p52-dependent NF-kappaB signaling" NARROW [PMID:18292232] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0038062 +name: protein tyrosine kinase collagen receptor activity +namespace: molecular_function +def: "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710] +synonym: "collagen RTK activity" EXACT [PMID:21568710] +synonym: "discoidin domain receptor" RELATED [PMID:16626936] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +is_a: GO:0038064 ! collagen receptor activity + +[Term] +id: GO:0038063 +name: collagen-activated tyrosine kinase receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936] +synonym: "collagen-activated RTK signaling pathway" EXACT [PMID:21568710] +synonym: "collagen-activated tyrosine kinase receptor signalling pathway" EXACT [GOC:mah] +synonym: "DDR signaling pathway" NARROW [PMID:16626936] +synonym: "discoidin domain receptor signaling pathway" NARROW [PMID:16626936] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +is_a: GO:0038065 ! collagen-activated signaling pathway + +[Term] +id: GO:0038064 +name: collagen receptor activity +namespace: molecular_function +def: "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:uh, PMID:21568710] +synonym: "transmembrane collagen receptor activity" EXACT [PMID:21568710] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0038065 +name: collagen-activated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:21568710] +synonym: "collagen-activated signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038066 +name: p38MAPK cascade +namespace: biological_process +def: "An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:signaling, PMID:20811974] +synonym: "p38 cascade" EXACT [PMID:20811974] +synonym: "p38 MAPK cascade" EXACT [GOC:bf] +is_a: GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0038067 +name: obsolete MAP kinase activity involved in cell wall organization or biogenesis +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase activity involved in cell wall biogenesis" NARROW [] +synonym: "MAP kinase activity involved in cell wall integrity" RELATED [GOC:vw] +synonym: "MAPK activity involved in cell wall biogenesis" NARROW [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038068 +name: obsolete MAP kinase kinase activity involved in cell wall organization or biogenesis +namespace: molecular_function +def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase kinase activity involved in cell wall biogenesis" NARROW [GOC:vw] +synonym: "MAP2K activity involved in cell wall integrity" EXACT [GOC:bf] +synonym: "MAPKK activity involved in cell wall integrity" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0038069 +name: obsolete MAP kinase phosphatase activity involved in regulation of cell wall biogenesis +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "Mpk1 phosphatase activity" NARROW [PMID:10523653] +synonym: "Slt2 phosphatase activity" NARROW [PMID:10523653] +is_obsolete: true + +[Term] +id: GO:0038070 +name: obsolete MAP kinase kinase kinase activity involved in cell wall organization or biogenesis +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase kinase kinase activity involved in cell wall biogenesis" EXACT [GOC:vw] +synonym: "MAP3K activity involved in cell wall integrity" EXACT [GOC:bf] +synonym: "MAPKKK activity involved in cell wall integrity" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0038071 +name: obsolete MAP kinase activity involved in conjugation with cellular fusion +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAPK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038072 +name: obsolete MAP kinase kinase activity involved in conjugation with cellular fusion +namespace: molecular_function +def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP2K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] +synonym: "MAPKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038073 +name: obsolete MAP kinase kinase kinase activity involved in conjugation with cellular fusion +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP3K activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] +synonym: "MAPKKK activity involved in conjugation with cellular fusion" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038074 +name: obsolete MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAPK phosphatase activity involved in regulation of conjugation with cellular fusion" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0038075 +name: obsolete MAP kinase activity involved in innate immune response +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] +comment: This term was obsoleted because it should be represented as a GO-CAM model. +synonym: "MAPK activity involved in innate immune response" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038076 +name: obsolete MAP kinase kinase activity involved in innate immune response +namespace: molecular_function +def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP2K activity involved in innate immune response" EXACT [GOC:signaling] +synonym: "MAPKK activity involved in innate immune response" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038077 +name: obsolete MAP kinase kinase kinase activity involved in innate immune response +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP3K activity involved in innate immune response" EXACT [GOC:signaling] +synonym: "MAPKKK activity involved in innate immune response" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038078 +name: obsolete MAP kinase phosphatase activity involved in regulation of innate immune response +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling] +comment: This term was obsoleted because it represents a biological process within the molecular function branch. +synonym: "MAPK phosphatase activity involved in regulation of innate immune response" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0038079 +name: obsolete MAP kinase activity involved in osmosensory signaling pathway +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "MAPK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038080 +name: obsolete MAP kinase kinase activity involved in osmosensory signaling pathway +namespace: molecular_function +def: "OBSOLETE. Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "MAP2K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] +synonym: "MAPKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038081 +name: obsolete MAP kinase kinase kinase activity involved in osmosensory signaling pathway +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "MAP kinase kinase kinase activity involved in osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "MAP3K activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] +synonym: "MAPKKK activity involved in osmosensory signaling pathway" EXACT [GOC:signaling] +is_obsolete: true + +[Term] +id: GO:0038082 +name: obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling] +comment: This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. +synonym: "Hog1 phosphatase activity" NARROW [PMID:20880736] +synonym: "MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway" EXACT [GOC:mah] +synonym: "MAPK phosphatase activity involved in regulation of osmosensory signaling pathway" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0038083 +name: peptidyl-tyrosine autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein." [PMID:10037737, PMID:10068444, PMID:10940390] +synonym: "receptor tyrosine kinase autophosphorylation" NARROW [PMID:20432069] +synonym: "RTK autophosphorylation" NARROW [PMID:20432069] +synonym: "tyrosine autophosphorylation" EXACT [PMID:16431914] +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0038084 +name: vascular endothelial growth factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] +comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'. +synonym: "vascular endothelial growth factor signalling pathway" EXACT [GOC:bf] +synonym: "VEGF signaling" EXACT [GOC:bf] +synonym: "VEGF-activated signaling pathway" EXACT [GOC:bf] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus + +[Term] +id: GO:0038085 +name: vascular endothelial growth factor binding +namespace: molecular_function +def: "Binding to a vascular endothelial growth factor." [PMID:17470632] +synonym: "VEGF binding" EXACT [GOC:bf] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0038086 +name: VEGF-activated platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] +synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway" EXACT [GOC:bf] +synonym: "VEGF-A/PDGFR signaling" NARROW [PMID:17470632] +synonym: "VEGF-activated PDGFR signalling pathway" EXACT [GOC:bf] +synonym: "VEGF-activated platelet-derived growth factor receptor signalling pathway" EXACT [GOC:bf] +synonym: "VEGF/PDGFR signaling pathway" EXACT [PMID:17470632] +is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway +is_a: GO:0048008 ! platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0038087 +name: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] +synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway" EXACT [GOC:bf] +synonym: "VEGF-A/PDGFRalpha signaling" NARROW [PMID:17470632] +synonym: "VEGF-activated PDGFRalpha signalling pathway" EXACT [GOC:bf] +synonym: "VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:bf] +synonym: "VEGF/PDGFRalpha signaling pathway" EXACT [PMID:17470632] +is_a: GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway +is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0038088 +name: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632] +synonym: "vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway" EXACT [GOC:bf] +synonym: "VEGF-A/PDGFRbeta signaling" NARROW [PMID:17470632] +synonym: "VEGF-activated PDGFRbeta signalling pathway" EXACT [GOC:bf] +synonym: "VEGF-activated platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:bf] +synonym: "VEGF/PDGFRbeta signaling pathway" EXACT [PMID:17470632] +is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway +is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0038089 +name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling] +synonym: "positive regulation of cell migration by vascular endothelial growth factor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of cell migration by VEGF signaling pathway" EXACT [GOC:bf] +synonym: "VEGF-A-induced cell migration" NARROW [PMID:17470632] +synonym: "VEGF-induced cell migration" EXACT [GOC:bf] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway + +[Term] +id: GO:0038090 +name: positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PMID:17470632] +synonym: "positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of cell migration by VEGF/PDGFR signaling pathway" EXACT [PMID:17470632] +synonym: "VEGF/PDGFR-induced cell migration" EXACT [PMID:17470632] +is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway +is_a: GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway + +[Term] +id: GO:0038091 +name: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation." [GOC:signaling, PMID:17470632] +synonym: "positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of cell proliferation by VEGF/PDGFR signaling pathway" EXACT [GOC:bf] +synonym: "VEGF-A-induced cell proliferation" NARROW [PMID:17470632] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0038086 ! VEGF-activated platelet-derived growth factor receptor signaling pathway + +[Term] +id: GO:0038092 +name: nodal signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255] +synonym: "nodal signaling" EXACT [GOC:bf] +synonym: "nodal signalling pathway" EXACT [GOC:mah] +is_a: GO:0032924 ! activin receptor signaling pathway + +[Term] +id: GO:0038093 +name: Fc receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor] +synonym: "Fc receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway + +[Term] +id: GO:0038094 +name: Fc-gamma receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038] +synonym: "Fc-gamma receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0038093 ! Fc receptor signaling pathway + +[Term] +id: GO:0038095 +name: Fc-epsilon receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725] +synonym: "Fc-epsilon receptor signalling pathway" EXACT [GOC:bf] +is_a: GO:0038093 ! Fc receptor signaling pathway + +[Term] +id: GO:0038096 +name: Fc-gamma receptor signaling pathway involved in phagocytosis +namespace: biological_process +def: "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916] +synonym: "Fc gamma receptor-dependent phagocytosis" EXACT [PMID:18832707] +synonym: "Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:bf] +synonym: "Fcgamma receptor-mediated phagocytosis" EXACT [PMID:15466916] +synonym: "IgG-mediated phagocytosis" EXACT [PMID:1248849] +is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway +is_a: GO:0002433 ! immune response-regulating cell surface receptor signaling pathway involved in phagocytosis +is_a: GO:0038094 ! Fc-gamma receptor signaling pathway + +[Term] +id: GO:0038097 +name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway +namespace: biological_process +def: "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:phg, PMID:12413516] +synonym: "Fc epsilon RI-dependent mast cell activation" EXACT [PMID:18377769] +synonym: "Fc epsilon RI-mediated mast cell activation" EXACT [PMID:17336609] +synonym: "positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0002431 ! Fc receptor mediated stimulatory signaling pathway +is_a: GO:0033005 ! positive regulation of mast cell activation +is_a: GO:0038095 ! Fc-epsilon receptor signaling pathway + +[Term] +id: GO:0038098 +name: sequestering of BMP from receptor via BMP binding +namespace: biological_process +def: "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014] +synonym: "extracellular sequestering of BMP" BROAD [GOC:bf] +synonym: "extracellular sequestering of bone morphogenetic protein" BROAD [GOC:bf] +is_a: GO:0030514 ! negative regulation of BMP signaling pathway +is_a: GO:0035581 ! sequestering of extracellular ligand from receptor + +[Term] +id: GO:0038099 +name: nodal receptor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals)." [GOC:bf, GOC:signaling, PMID:15062104] +synonym: "ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:bf] +synonym: "nodal receptor complex formation" EXACT [GOC:bf] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0038092 ! nodal signaling pathway + +[Term] +id: GO:0038100 +name: nodal binding +namespace: molecular_function +def: "Binding to a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0038101 +name: sequestering of nodal from receptor via nodal binding +namespace: biological_process +def: "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor." [GOC:signaling, PMID:14570583, PMID:15062104] +synonym: "binding to and sequestering nodal" EXACT [GOC:bf] +synonym: "extracellular regulation of nodal" BROAD [GOC:bf] +synonym: "nodal antagonist activity" BROAD [PMID:14570583] +is_a: GO:0035581 ! sequestering of extracellular ligand from receptor +relationship: part_of GO:1900108 ! negative regulation of nodal signaling pathway + +[Term] +id: GO:0038102 +name: activin receptor antagonist activity +namespace: molecular_function +def: "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104] +comment: This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal. +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0038103 +name: activin receptor antagonist activity involved in negative regulation of nodal signaling pathway +namespace: molecular_function +def: "Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104] +synonym: "activin receptor antagonist activity involved in negative regulation of nodal signalling pathway" EXACT [GOC:mah] +synonym: "nodal antagonist activity" EXACT [GOC:bf] +is_a: GO:0038102 ! activin receptor antagonist activity + +[Term] +id: GO:0038104 +name: nodal receptor complex +namespace: cellular_component +def: "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell." [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104] +comment: Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex. +synonym: "ActRIIB.ALK4.EGF-CFC complex" NARROW [GOC:bf] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0038105 +name: sequestering of TGFbeta from receptor via TGFbeta binding +namespace: biological_process +def: "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014] +comment: This term is for annotation of gene products that bind to TGFbeta. For gene products that tether the TGFbeta-containing latency complex to the extracellular matrix, but do not necessarily bind TGF-beta directly, consider instead annotating to 'sequestering of TGFbeta in extracellular matrix ; GO:0035583'. +synonym: "extracellular sequestering of TGFbeta" BROAD [GOC:bf] +synonym: "extracellular sequestering of transforming growth factor-beta" BROAD [GOC:bf] +is_a: GO:0035581 ! sequestering of extracellular ligand from receptor + +[Term] +id: GO:0038106 +name: choriogonadotropin hormone binding +namespace: molecular_function +def: "Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit." [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin] +synonym: "chorionic gonadotrophin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin] +synonym: "chorionic gonadotropin binding" EXACT [Wikipedia:Human_chorionic_gonadotropin] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0038107 +name: nodal signaling pathway involved in determination of left/right asymmetry +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706] +synonym: "nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] +synonym: "regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry" EXACT [GOC:bf] +is_a: GO:0038092 ! nodal signaling pathway +is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry + +[Term] +id: GO:0038108 +name: negative regulation of appetite by leptin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food." [GOC:BHF, GOC:vk, PMID:19150989] +synonym: "inhibition of appetite by leptin signaling" EXACT [GOC:bf] +synonym: "negative regulation of appetite by leptin-mediated signalling pathway" EXACT [GOC:mah] +synonym: "reduction of appetite by leptin-mediated signaling" EXACT [GOC:bf] +synonym: "suppression of appetite by leptin-mediated signaling pathway" EXACT [GOC:bf] +is_a: GO:0032099 ! negative regulation of appetite +is_a: GO:0033210 ! leptin-mediated signaling pathway + +[Term] +id: GO:0038109 +name: Kit signaling pathway +namespace: biological_process +def: "A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell." [GOC:nhn, GOC:signaling, PMID:16129412] +synonym: "Kit signalling pathway" EXACT [GOC:mah] +synonym: "SCF signaling pathway" EXACT [PMID:18787413] +synonym: "stem cell factor receptor signaling pathway" EXACT [PMID:16129412] +synonym: "stem cell factor signaling pathway" EXACT [PMID:16129412] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0036216 ! cellular response to stem cell factor stimulus + +[Term] +id: GO:0038110 +name: interleukin-2-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-2-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-2-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071352 ! cellular response to interleukin-2 + +[Term] +id: GO:0038111 +name: interleukin-7-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-7-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-7-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0098761 ! cellular response to interleukin-7 + +[Term] +id: GO:0038112 +name: interleukin-8-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-8-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-8-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0098759 ! cellular response to interleukin-8 + +[Term] +id: GO:0038113 +name: interleukin-9-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-9-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-9-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071355 ! cellular response to interleukin-9 + +[Term] +id: GO:0038114 +name: interleukin-21-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-21-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-21-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0098757 ! cellular response to interleukin-21 + +[Term] +id: GO:0038115 +name: chemokine (C-C motif) ligand 19 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] +comment: The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'. +synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845] +synonym: "CCL19-mediated signaling pathway" EXACT [PMID:15059845] +synonym: "chemokine (C-C motif) ligand 19 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038116 +name: chemokine (C-C motif) ligand 21 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] +comment: The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. +synonym: "C-C chemokine receptor type 7 signaling pathway" RELATED [PMID:15059845, PR:000001203] +synonym: "CCL21-mediated signaling pathway" EXACT [PMID:15059845] +synonym: "chemokine (C-C motif) ligand 21 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038117 +name: C-C motif chemokine 19 receptor activity +namespace: molecular_function +def: "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845] +synonym: "CCL19 receptor activity" RELATED [PMID:15059845] +is_a: GO:0016493 ! C-C chemokine receptor activity + +[Term] +id: GO:0038118 +name: C-C chemokine receptor CCR7 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365] +comment: This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. +synonym: "C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:mah] +synonym: "CCR7 signaling pathway" RELATED [] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038119 +name: CCL19-activated CCR7 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] +synonym: "CCL19-activated CCR7 signalling pathway" EXACT [GOC:mah] +is_a: GO:0038115 ! chemokine (C-C motif) ligand 19 signaling pathway +is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway + +[Term] +id: GO:0038120 +name: CCL21-activated CCR7 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845] +synonym: "CCL21-activated CCR7 signalling pathway" EXACT [GOC:mah] +is_a: GO:0038116 ! chemokine (C-C motif) ligand 21 signaling pathway +is_a: GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway + +[Term] +id: GO:0038121 +name: C-C motif chemokine 21 receptor activity +namespace: molecular_function +def: "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845] +synonym: "CCL21 receptor activity" RELATED [PMID:15059845] +is_a: GO:0016493 ! C-C chemokine receptor activity + +[Term] +id: GO:0038122 +name: C-C motif chemokine 5 receptor activity +namespace: molecular_function +def: "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling] +synonym: "CCL5 receptor activity" EXACT [PR:000002094] +synonym: "RANTES receptor activity" EXACT [GOC:bf] +synonym: "small inducible cytokine A5 receptor activity" EXACT [PR:000002094] +is_a: GO:0016493 ! C-C chemokine receptor activity + +[Term] +id: GO:0038123 +name: toll-like receptor TLR1:TLR2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230] +synonym: "TLR2:TLR1 signaling pathway" EXACT [GOC:bf] +synonym: "toll-like receptor TLR1:TLR2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0038124 +name: toll-like receptor TLR6:TLR2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230] +synonym: "TLR2:TLR6 signaling pathway" EXACT [GOC:bf] +synonym: "toll-like receptor TLR6:TLR2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0002224 ! toll-like receptor signaling pathway + +[Term] +id: GO:0038127 +name: ERBB signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Wikipedia:ErbB] +synonym: "EGF receptor family signaling pathway" EXACT [PMID:11597398] +synonym: "EGFR family signaling pathway" RELATED [PMID:11597398] +synonym: "ErbB signaling" EXACT [PMID:20933094, Wikipedia:ErbB] +synonym: "ERBB signalling pathway" EXACT [GOC:mah] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0038128 +name: ERBB2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, Reactome:R-HSA-1227986] +synonym: "ERBB2 signalling pathway" EXACT [GOC:mah] +synonym: "HER2 signaling pathway" EXACT [PR:000002082] +synonym: "NEU signaling" EXACT [Reactome:R-HSA-1227986] +synonym: "receptor tyrosine-protein kinase erbB-2 signaling pathway" EXACT [PR:000002082] +is_a: GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:0038129 +name: ERBB3 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, Reactome:R-HSA-1247497] +synonym: "ERBB3 signalling pathway" EXACT [GOC:mah] +synonym: "HER3 signaling pathway" EXACT [PR:000007159] +synonym: "receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [PR:000007159] +is_a: GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:0038130 +name: ERBB4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, Reactome:R-HSA-1236394] +synonym: "ERBB4 signalling pathway" EXACT [GOC:mah] +synonym: "HER4 signaling pathway" EXACT [PR:000007160] +synonym: "receptor tyrosine-protein kinase erbB-4 signaling pathway" EXACT [PR:000007160] +is_a: GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:0038131 +name: neuregulin receptor activity +namespace: molecular_function +def: "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328] +comment: Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'. +synonym: "NRG receptor activity" EXACT [PMID:16460914] +synonym: "NRG1 receptor activity" NARROW [PMID:16460914] +synonym: "NRG2 receptor activity" NARROW [PMID:16460914] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0038132 +name: neuregulin binding +namespace: molecular_function +def: "Binding to a neuregulin, a member of the EGF family of growth factors." [GOC:bf, GOC:signaling] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0038133 +name: ERBB2-ERBB3 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] +synonym: "ERBB2-ERBB3 signalling pathway" EXACT [GOC:mah] +synonym: "HER2-HER3 signaling pathway" EXACT [PR:000002082, PR:000007159] +is_a: GO:0038128 ! ERBB2 signaling pathway +is_a: GO:0038129 ! ERBB3 signaling pathway + +[Term] +id: GO:0038134 +name: ERBB2-EGFR signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] +synonym: "EGFR-HER2 signaling pathway" EXACT [PR:000002082, PR:000006933] +synonym: "ERBB2-EGFR signalling pathway" EXACT [GOC:mah] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +is_a: GO:0038128 ! ERBB2 signaling pathway + +[Term] +id: GO:0038135 +name: ERBB2-ERBB4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1963589] +synonym: "ERBB2-ERBB4 signalling pathway" EXACT [GOC:mah] +synonym: "HER2-HER4 signaling pathway" EXACT [PR:000002082, PR:000007160] +is_a: GO:0038128 ! ERBB2 signaling pathway +is_a: GO:0038130 ! ERBB4 signaling pathway + +[Term] +id: GO:0038136 +name: ERBB3-ERBB4 signaling pathway +namespace: biological_process +def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977958] +synonym: "ERBB3-ERBB4 signalling pathway" EXACT [GOC:mah] +synonym: "HER3-HER4 signaling pathway" EXACT [PR:000007159, PR:000007160] +is_a: GO:0038129 ! ERBB3 signaling pathway +is_a: GO:0038130 ! ERBB4 signaling pathway + +[Term] +id: GO:0038137 +name: ERBB4-EGFR signaling pathway +namespace: biological_process +def: "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977959] +synonym: "ERBB1-ERBB4 signaling pathway" EXACT [PR:000006933, PR:000007160] +synonym: "ERBB4-EGFR signalling pathway" EXACT [GOC:mah] +synonym: "HER1-HER4 signaling pathway" EXACT [PR:000006933, PR:000007160] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +is_a: GO:0038130 ! ERBB4 signaling pathway + +[Term] +id: GO:0038138 +name: ERBB4-ERBB4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250220] +synonym: "ERBB4 homodimeric signaling pathway" EXACT [PMID:16460914] +synonym: "ERBB4-ERBB4 signalling pathway" EXACT [GOC:mah] +synonym: "HER4-HER4 signaling pathway" EXACT [PR:000007160] +is_a: GO:0038130 ! ERBB4 signaling pathway + +[Term] +id: GO:0038139 +name: ERBB4-EGFR complex +namespace: cellular_component +def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1)." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977956] +synonym: "EGFR-ERBB4 complex" EXACT [GOC:bf] +synonym: "ERBB4:EGFR heterodimer" EXACT [Reactome:R-HSA-1977956] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038140 +name: ERBB4-ERBB3 complex +namespace: cellular_component +def: "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1977955] +synonym: "ERBB3-ERBB4 complex" EXACT [GOC:bf] +synonym: "ERBB4:ERBB3 heterodimer" EXACT [Reactome:117805.1] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038141 +name: ERBB4-ERBB4 complex +namespace: cellular_component +def: "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4)." [GOC:signaling, PMID:16460914, Reactome:R-HSA-1250221] +synonym: "ERBB4 homodimer" EXACT [Reactome:R-HSA-1977955] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038142 +name: EGFR:ERBB2 complex +namespace: cellular_component +def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, PMID:1973074, Reactome:R-HSA-1227939, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] +synonym: "EGF:EGFR:ERBB2 complex" NARROW [Reactome:R-HSA-1963573] +synonym: "EGFR:ERBB2 heterodimer" RELATED [Reactome:R-HSA-1963573] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038143 +name: ERBB3:ERBB2 complex +namespace: cellular_component +def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3." [GOC:signaling, PMID:16460914, PMID:8665853, Reactome:R-HSA-1247502, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] +synonym: "EGFR:ERBB2 heterodimer" NARROW [Reactome:R-HSA-1963573] +synonym: "NRG1/2:ERBB3:ERBB2" NARROW [Reactome:R-HSA-1247502] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038144 +name: ERBB4:ERBB2 complex +namespace: cellular_component +def: "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, PMID:16978839, Reactome:R-HSA-1250224, Reactome:R-HSA-1963573, Reactome:R-HSA-1963589] +synonym: "ERBB4:ERBB2 heterodimer" NARROW [Reactome:R-HSA-1250224] +synonym: "NRGs/EGFLs:ERBB4:ERBB2" NARROW [Reactome:R-HSA-1250224] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0038145 +name: macrophage colony-stimulating factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, Wikipedia:Macrophage_colony-stimulating_factor] +synonym: "M-CSF signaling pathway" EXACT [PMID:12138890] +synonym: "macrophage colony-stimulating factor signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus + +[Term] +id: GO:0038146 +name: chemokine (C-X-C motif) ligand 12 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:Stromal_cell-derived_factor-1] +synonym: "CXCL12 signaling pathway" EXACT [GOC:bf] +synonym: "CXCL12-activated CXCR7 signaling pathway" NARROW [GOC:bf] +synonym: "SDF1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066] +synonym: "stromal cell-derived factor-1 signaling pathway" EXACT [HGNC:10672, PMID:22204316, PR:000006066] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038147 +name: C-X-C motif chemokine 12 receptor activity +namespace: molecular_function +def: "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:22204316] +synonym: "CXCL12 receptor activity" EXACT [GOC:bf] +synonym: "CXCR4" NARROW [PMID:22204316] +synonym: "CXCR7" NARROW [PMID:22204316] +synonym: "SDF-1 receptor activity" RELATED [HGNC:10672, PR:000006066] +synonym: "stromal cell-derived factor-1 receptor activity" EXACT [HGNC:10672, PR:000006066] +is_a: GO:0016494 ! C-X-C chemokine receptor activity + +[Term] +id: GO:0038148 +name: chemokine (C-C motif) ligand 2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, Wikipedia:CCL2] +synonym: "CCL2 signaling pathway" EXACT [GOC:bf] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038149 +name: C-C motif chemokine 2 receptor activity +namespace: molecular_function +def: "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling] +synonym: "CCL2 receptor activity" EXACT [GOC:bf] +is_a: GO:0016493 ! C-C chemokine receptor activity + +[Term] +id: GO:0038150 +name: C-C chemokine receptor CCR2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "C-C chemokine receptor type 2 signaling pathway" EXACT [PR:000001199] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038151 +name: CCL2-activated CCR2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "CCL2/CCR2 signaling pathway" EXACT [GOC:bf] +is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway +is_a: GO:0038150 ! C-C chemokine receptor CCR2 signaling pathway + +[Term] +id: GO:0038152 +name: C-C chemokine receptor CCR4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "C-C chemokine receptor type 4 signaling pathway" EXACT [PR:000001200] +synonym: "chemokine receptor CCR4 signaling pathway" EXACT [GOC:bf] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038153 +name: CCL2-activated CCR4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "CCL2/CCR4 signaling pathway" RELATED [GOC:bf] +is_a: GO:0038148 ! chemokine (C-C motif) ligand 2 signaling pathway +is_a: GO:0038152 ! C-C chemokine receptor CCR4 signaling pathway + +[Term] +id: GO:0038154 +name: interleukin-11-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-11-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-11-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038155 +name: interleukin-23-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-23-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-23-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038156 +name: interleukin-3-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "IL-3-mediated signaling pathway" EXACT [GOC:bf] +synonym: "interleukin-3-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038157 +name: granulocyte-macrophage colony-stimulating factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors." [GOC:nhn, GOC:signaling, PMID:17027509] +synonym: "CSF2 signaling pathway" EXACT [PR:000005931] +synonym: "GM-CSF receptor signaling pathway" EXACT [GOC:nhn] +synonym: "GM-CSF signaling pathway" EXACT [PR:000005931] +synonym: "granulocyte-macrophage colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn] +synonym: "granulocyte-macrophage colony-stimulating factor signalling pathway" RELATED [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038158 +name: granulocyte colony-stimulating factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R)." [GOC:nhn, GOC:signaling] +synonym: "CSF3 signaling pathway" EXACT [PR:000005932] +synonym: "G-CSF receptor signaling pathway" EXACT [GOC:nhn] +synonym: "G-CSF signaling pathway" EXACT [PR:000005932] +synonym: "granulocyte colony-stimulating factor receptor signaling pathway" EXACT [GOC:nhn] +synonym: "granulocyte colony-stimulating factor signalling pathway" RELATED [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038159 +name: C-X-C chemokine receptor CXCR4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling] +synonym: "CXCR4 signaling pathway" EXACT [PR:000001208] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038160 +name: CXCL12-activated CXCR4 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn] +synonym: "CXCL12-activated CXCR4 signalling pathway" EXACT [GOC:bf] +is_a: GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway +is_a: GO:0038159 ! C-X-C chemokine receptor CXCR4 signaling pathway + +[Term] +id: GO:0038161 +name: prolactin signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429] +synonym: "PRL signaling pathway" EXACT [PMID:21664429, PR:000013246] +synonym: "prolactin-mediated signaling pathway" EXACT [GOC:bf] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038162 +name: erythropoietin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:12489509] +synonym: "EPO-R signaling pathway" EXACT [PMID:12489509] +synonym: "erythropoietin receptor signaling pathway" EXACT [PMID:12489509] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0036018 ! cellular response to erythropoietin + +[Term] +id: GO:0038163 +name: thrombopoietin-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:19630807] +synonym: "THPO signaling pathway" EXACT [PR:000016318] +synonym: "THPO/MPL signaling pathway" EXACT [PMID:18371409] +synonym: "thrombopoietin receptor signaling pathway" EXACT [GOC:nhn, PR:000001939] +is_a: GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0038164 +name: thrombopoietin receptor activity +namespace: molecular_function +def: "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19630807] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0038165 +name: oncostatin-M-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways." [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586] +synonym: "oncostatin-M signaling pathway" EXACT [GOC:bf] +synonym: "OSM signaling pathway" EXACT [PMID:10579456, PR:000012059] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038166 +name: angiotensin-activated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869] +synonym: "angiotensin II-mediated signaling pathway" EXACT [GOC:bf] +synonym: "angiotensin receptor signaling pathway" EXACT [GOC:bf, GOC:mtg_cardiac_conduct_nov11] +synonym: "angiotensin-mediated signaling pathway" RELATED [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +relationship: part_of GO:1904385 ! cellular response to angiotensin + +[Term] +id: GO:0038167 +name: epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB." [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240] +synonym: "EGFR signaling pathway via activation of NF-kappaB" EXACT [GOC:bf] +synonym: "epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity" EXACT [] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0038168 +name: epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB." [GOC:bf, PMID:22132240] +synonym: "EGFR signaling pathway via IKK-dependent activation of NF-kappaB" EXACT [GOC:bf] +synonym: "EGFR signaling pathway via IKK/NF-kappaB cascade" EXACT [GOC:bf] +is_a: GO:0038167 ! epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity + +[Term] +id: GO:0038169 +name: somatostatin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369] +comment: In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. +synonym: "SST receptor signaling pathway" EXACT [GOC:bf] +synonym: "SSTR signaling pathway" RELATED [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038170 +name: somatostatin signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin] +synonym: "somatostatin signalling pathway" EXACT [GOC:bf] +synonym: "somatostatin-activated somatostatin receptor signaling pathway" EXACT [GOC:bf] +synonym: "somatostatin-mediated signaling pathway" EXACT [GOC:bf] +synonym: "somatotrophin release inhibiting factor signaling pathway" EXACT [Wikipedia:Somatostatin] +synonym: "SRIF signaling pathway" EXACT [Wikipedia:Somatostatin] +synonym: "SST signaling pathway" EXACT [Wikipedia:Somatostatin] +is_a: GO:0009755 ! hormone-mediated signaling pathway +is_a: GO:0038169 ! somatostatin receptor signaling pathway + +[Term] +id: GO:0038171 +name: cannabinoid signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid] +synonym: "cannabinoid receptor signaling pathway" EXACT [GOC:bf] +synonym: "cannabinoid-activated signaling pathway" EXACT [GOC:bf] +synonym: "cannabinoid-mediated signaling pathway" EXACT [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038172 +name: interleukin-33-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling] +synonym: "IL-33-mediated signaling pathway" EXACT [GOC:bf] +synonym: "IL33 signaling pathway" EXACT [PR:000001389] +synonym: "interleukin-33 signaling pathway" RELATED [GOC:jc] +synonym: "interleukin-33-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038173 +name: interleukin-17A-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling] +synonym: "IL-17A-mediated signaling pathway" EXACT [GOC:bf] +synonym: "IL17A signaling pathway" EXACT [PR:000001138, Wikipedia:IL17A] +synonym: "interleukin-17A signaling pathway" RELATED [GOC:jc] +synonym: "interleukin-17A-mediated signalling pathway" EXACT [GOC:bf] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0038174 +name: interleukin-17A receptor activity +namespace: molecular_function +def: "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling] +is_a: GO:0030368 ! interleukin-17 receptor activity + +[Term] +id: GO:0038175 +name: negative regulation of SREBP signaling pathway in response to increased oxygen levels +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." [GOC:al, PMID:22017871] +synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen" RELATED [PMID:22017871] +synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels" EXACT [GOC:bf, GOC:vw] +is_a: GO:2000639 ! negative regulation of SREBP signaling pathway +relationship: part_of GO:0036295 ! cellular response to increased oxygen levels + +[Term] +id: GO:0038176 +name: positive regulation of SREBP signaling pathway in response to decreased oxygen levels +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels." [GOC:al, PMID:22017871] +synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen" RELATED [PMID:22017871] +synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels" EXACT [GOC:bf, GOC:vw] +is_a: GO:2000640 ! positive regulation of SREBP signaling pathway +relationship: part_of GO:0036294 ! cellular response to decreased oxygen levels + +[Term] +id: GO:0038177 +name: death receptor agonist activity +namespace: molecular_function +def: "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." [GOC:mtg_apoptosis, GOC:pr] +synonym: "death receptor activator activity" EXACT [GOC:pr] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0038178 +name: complement component C5a signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor." [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a] +synonym: "complement component C5a-induced signaling pathway" EXACT [GOC:jc] +is_a: GO:0002430 ! complement receptor mediated signaling pathway +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038179 +name: neurotrophin signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, Wikipedia:Neurotrophin] +comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors. +synonym: "neurotrophin receptor signaling pathway" EXACT [PMID:22333586] +is_a: GO:0007166 ! cell surface receptor signaling pathway +relationship: part_of GO:0071363 ! cellular response to growth factor stimulus + +[Term] +id: GO:0038180 +name: nerve growth factor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933] +comment: Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase. +synonym: "nerve growth factor signalling pathway" EXACT [GOC:bf] +synonym: "NGF signaling pathway" EXACT [PR:000011194, Wikipedia:Nerve_growth_factor] +xref: Wikipedia:Nerve_growth_factor +is_a: GO:0038179 ! neurotrophin signaling pathway +relationship: part_of GO:1990090 ! cellular response to nerve growth factor stimulus + +[Term] +id: GO:0038181 +name: bile acid receptor activity +namespace: molecular_function +def: "Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile." [GOC:bf, PMID:10334992, PMID:12718893] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0038182 +name: G protein-coupled bile acid receptor activity +namespace: molecular_function +def: "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, PMID:12524422] +synonym: "cell surface bile acid receptor" BROAD [GOC:bf] +synonym: "G-protein coupled bile acid receptor activity" EXACT [] +synonym: "membrane bile acid receptor activity" BROAD [PMID:12419312] +xref: Wikipedia:G_protein-coupled_bile_acid_receptor +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0038181 ! bile acid receptor activity + +[Term] +id: GO:0038183 +name: bile acid signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a bile acid to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:12016314] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0038184 +name: cell surface bile acid receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12419312, PMID:19442546] +synonym: "membrane bile acid receptor signaling pathway" RELATED [GOC:bf] +is_a: GO:0007166 ! cell surface receptor signaling pathway +is_a: GO:0038183 ! bile acid signaling pathway + +[Term] +id: GO:0038185 +name: intracellular bile acid receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:10334992] +synonym: "nuclear bile acid receptor signaling pathway" RELATED [] +is_a: GO:0030522 ! intracellular receptor signaling pathway +is_a: GO:0038183 ! bile acid signaling pathway + +[Term] +id: GO:0038186 +name: lithocholic acid receptor activity +namespace: molecular_function +def: "Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity." [GOC:bf, PMID:12016314, PMID:12419312] +synonym: "LCA receptor activity" EXACT [PMID:10334992] +is_a: GO:0038181 ! bile acid receptor activity + +[Term] +id: GO:0038187 +name: pattern recognition receptor activity +namespace: molecular_function +alt_id: GO:0008329 +def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response." [GOC:ar, GOC:bf] +synonym: "macrophage receptor activity" RELATED [] +synonym: "MAMP receptor activity" NARROW [] +synonym: "microbe-associated molecular pattern receptor activity" NARROW [] +synonym: "PAMP receptor activity" NARROW [] +synonym: "pathogen associated molecular pattern receptor activity" NARROW [] +synonym: "PRR" EXACT [] +synonym: "PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor] +synonym: "signaling pattern recognition receptor activity" RELATED [] +xref: Wikipedia:Pattern_recognition_receptor +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0038188 +name: cholecystokinin signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of cholecystokinin binding to a receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948] +synonym: "CCK signaling" EXACT [PMID:11181948, Wikipedia:Cholecystokinin] +synonym: "cholecystokinin receptor signaling pathway" RELATED [GOC:bf] +xref: Wikipedia:Cholecystokinin +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038189 +name: neuropilin signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:12852851] +synonym: "Npn signaling" EXACT [PMID:12852851] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038190 +name: VEGF-activated neuropilin signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:rl, PMID:12852851] +synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway" RELATED [GOC:bf] +synonym: "VEGF-Npn-1 signaling" NARROW [PMID:12852851] +is_a: GO:0038084 ! vascular endothelial growth factor signaling pathway +is_a: GO:0038189 ! neuropilin signaling pathway + +[Term] +id: GO:0038191 +name: neuropilin binding +namespace: molecular_function +def: "Binding to a member of the neuropilin family." [GOC:bf, PMID:23871893] +synonym: "neuropilin-binding" EXACT [PMID:12852851] +synonym: "Nrp binding" EXACT [PMID:23871893] +synonym: "Nrp ligand" NARROW [PMID:23871893] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0038192 +name: gastric inhibitory peptide signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a gastric inhibitory peptide (GIP) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15955806] +synonym: "gastric inhibitory polypeptide receptor signaling pathway" EXACT [GOC:nhn] +synonym: "GIP signaling" EXACT [PMID:19251046] +synonym: "glucose-dependent insulinotropic polypeptide signaling" EXACT [PMID:19251046] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038193 +name: thromboxane A2 signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of thromboxane A2 binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15893915] +synonym: "TXA(2) receptor signaling" EXACT [PMID:15893915] +synonym: "TXA2 signaling" EXACT [PMID:15242977] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038194 +name: thyroid-stimulating hormone signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:10809230] +synonym: "thyrotropin signaling pathway" EXACT [GOC:gap, PMID:10809230] +synonym: "TSH signaling pathway" EXACT [PMID:10809230] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0038195 +name: urokinase plasminogen activator signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of urokinase plasminogen activator to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:9417082] +synonym: "uPA signaling pathway" EXACT [PMID:9417082] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0038196 +name: type III interferon signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far." [GOC:pg, GOC:signaling] +synonym: "interferon lambda signaling pathway" NARROW [PR:000001362] +synonym: "type III interferon-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071358 ! cellular response to type III interferon + +[Term] +id: GO:0038197 +name: type I interferon receptor complex +namespace: cellular_component +def: "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:cjm, GOC:signaling, PMID:17502368] +synonym: "interferon-alpha/beta receptor complex" NARROW [GOC:bf] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0038198 +name: auxin receptor activity +namespace: molecular_function +def: "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)." [GOC:signaling, PMID:15917797] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0038199 +name: ethylene receptor activity +namespace: molecular_function +def: "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity." [GOC:signaling, PMID:22467798, PMID:24012247] +synonym: "C2H4 receptor activity" EXACT [PMID:24012247] +synonym: "ethylene response sensor" RELATED [PMID:22467798] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0038200 +name: ethylene receptor histidine kinase activity +namespace: molecular_function +def: "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:signaling, PMID:22467798] +is_a: GO:0038199 ! ethylene receptor activity + +[Term] +id: GO:0038201 +name: TOR complex +namespace: cellular_component +def: "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K." [Wikipedia:MTORC1, Wikipedia:MTORC2] +synonym: "mTOR complex" NARROW [Wikipedia:MTORC1] +synonym: "target of rapamycin complex" EXACT [GOC:bf] +synonym: "TOR signaling complex" EXACT [GOC:bf] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0038202 +name: TORC1 signaling +namespace: biological_process +def: "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] +synonym: "TORC1 signal transduction" EXACT [GOC:signaling] +is_a: GO:0031929 ! TOR signaling + +[Term] +id: GO:0038203 +name: TORC2 signaling +namespace: biological_process +def: "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb] +synonym: "TORC2 signal transduction" EXACT [GOC:signaling] +is_a: GO:0031929 ! TOR signaling + +[Term] +id: GO:0039003 +name: pronephric field specification +namespace: biological_process +def: "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10] +synonym: "pronephric kidney field specification" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0039017 ! pattern specification involved in pronephros development +is_a: GO:0072004 ! kidney field specification + +[Term] +id: GO:0039004 +name: specification of pronephric proximal tubule identity +namespace: biological_process +def: "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] +is_a: GO:0039005 ! specification of pronephric tubule identity +is_a: GO:0072082 ! specification of proximal tubule identity +is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development +relationship: part_of GO:0039011 ! pronephric proximal tubule morphogenesis + +[Term] +id: GO:0039005 +name: specification of pronephric tubule identity +namespace: biological_process +def: "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10] +is_a: GO:0039017 ! pattern specification involved in pronephros development +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis + +[Term] +id: GO:0039006 +name: pronephric nephron tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10] +synonym: "pronephric tubule formation" EXACT [GOC:mtg_kidney_jan10] +synonym: "pronephros tubule formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072079 ! nephron tubule formation +relationship: part_of GO:0039008 ! pronephric nephron tubule morphogenesis +relationship: part_of GO:0072116 ! pronephros formation + +[Term] +id: GO:0039007 +name: pronephric nephron morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072028 ! nephron morphogenesis +relationship: part_of GO:0039019 ! pronephric nephron development +relationship: part_of GO:0072114 ! pronephros morphogenesis + +[Term] +id: GO:0039008 +name: pronephric nephron tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558] +is_a: GO:0072078 ! nephron tubule morphogenesis +relationship: part_of GO:0039007 ! pronephric nephron morphogenesis +relationship: part_of GO:0039020 ! pronephric nephron tubule development + +[Term] +id: GO:0039009 +name: rectal diverticulum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015] +synonym: "pronephric rectal diverticulum development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039010 +name: specification of pronephric distal tubule identity +namespace: biological_process +def: "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10] +is_a: GO:0039005 ! specification of pronephric tubule identity +is_a: GO:0072084 ! specification of distal tubule identity +is_a: GO:0072196 ! proximal/distal pattern formation involved in pronephric nephron development +relationship: part_of GO:0039013 ! pronephric distal tubule morphogenesis + +[Term] +id: GO:0039011 +name: pronephric proximal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] +synonym: "pronephros proximal tubule morphogenesis" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0039008 ! pronephric nephron tubule morphogenesis +is_a: GO:0072158 ! proximal tubule morphogenesis +relationship: part_of GO:0035776 ! pronephric proximal tubule development + +[Term] +id: GO:0039012 +name: pronephric sinus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039013 +name: pronephric distal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10] +is_a: GO:0039008 ! pronephric nephron tubule morphogenesis +is_a: GO:0072156 ! distal tubule morphogenesis +relationship: part_of GO:0035777 ! pronephric distal tubule development + +[Term] +id: GO:0039014 +name: cell differentiation involved in pronephros development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "cell differentiation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039015 +name: cell proliferation involved in pronephros development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10] +synonym: "cell proliferation involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039016 +name: cell-cell signaling involved in pronephros development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] +synonym: "cell-cell signaling involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +synonym: "cell-cell signalling involved in pronephros development" EXACT [GOC:mah] +is_a: GO:0060995 ! cell-cell signaling involved in kidney development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039017 +name: pattern specification involved in pronephros development +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] +synonym: "pattern specification involved in pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039018 +name: nephrostome development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039019 +name: pronephric nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785] +is_a: GO:0072006 ! nephron development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039020 +name: pronephric nephron tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0039019 ! pronephric nephron development + +[Term] +id: GO:0039021 +name: pronephric glomerulus development +namespace: biological_process +def: "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557] +comment: This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. +is_a: GO:0032835 ! glomerulus development +relationship: part_of GO:0039019 ! pronephric nephron development + +[Term] +id: GO:0039022 +name: pronephric duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150] +is_a: GO:0072176 ! nephric duct development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0039023 +name: pronephric duct morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150] +is_a: GO:0072178 ! nephric duct morphogenesis +relationship: part_of GO:0039022 ! pronephric duct development +relationship: part_of GO:0072114 ! pronephros morphogenesis + +[Term] +id: GO:0039501 +name: suppression by virus of host type I interferon production +namespace: biological_process +def: "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1113, VZ:875] +synonym: "negative regulation by virus of host type I interferon production" EXACT [GOC:bf] +synonym: "suppression by virus of host interferon type I production" EXACT [GOC:bf] +synonym: "suppression by virus of host type I IFN production" EXACT [GOC:bf] +xref: VZ:875 "Inhibition of host IFN-mediated response initiation by virus" +is_a: GO:0032480 ! negative regulation of type I interferon production +is_a: GO:0046775 ! suppression by virus of host cytokine production + +[Term] +id: GO:0039502 +name: suppression by virus of host type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1114, VZ:883] +synonym: "inhibition of host interferon signaling pathway by virus" RELATED [UniProtKB-KW:KW-1114] +synonym: "negative regulation by virus of host type I interferon-mediated signaling pathway" EXACT [GOC:bf] +synonym: "suppression by virus of host type I IFN-mediated signaling pathway" EXACT [GOC:bf] +synonym: "suppression by virus of host type I interferon-mediated signalling pathway" EXACT [GOC:bf] +xref: VZ:883 "Inhibition of host IFN-mediated response initiation by virus" +is_a: GO:0039503 ! suppression by virus of host innate immune response +is_a: GO:0060339 ! negative regulation of type I interferon-mediated signaling pathway +is_a: GO:0075114 ! suppression by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0039503 +name: suppression by virus of host innate immune response +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090] +synonym: "inhibition of host innate immune response by virus" EXACT [UniProtKB-KW:KW-1090] +synonym: "negative regulation by virus of host innate immune response" EXACT [GOC:bf] +synonym: "negative regulation by virus of host innate immunity" EXACT [GOC:bf] +synonym: "suppression by virus of host innate immunity" EXACT [GOC:pg] +is_a: GO:0030683 ! mitigation of host immune response by virus +is_a: GO:0050776 ! regulation of immune response +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0052170 ! suppression by symbiont of host innate immune response +is_a: GO:0075528 ! modulation by virus of host immune response + +[Term] +id: GO:0039504 +name: suppression by virus of host adaptive immune response +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1080] +synonym: "inhibition of host adaptive immune response by virus" EXACT [UniProtKB-KW:KW-1080] +synonym: "negative regulation by virus of host adaptive immune response" EXACT [GOC:bf] +synonym: "negative regulation by virus of host adaptive immunity" EXACT [GOC:bf] +synonym: "suppression by virus of host acquired immune response" EXACT [ISBN:068340007X] +is_a: GO:0030683 ! mitigation of host immune response by virus +is_a: GO:0052562 ! suppression by symbiont of host immune response +is_a: GO:0075528 ! modulation by virus of host immune response +relationship: negatively_regulates GO:0002250 ! adaptive immune response + +[Term] +id: GO:0039505 +name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II +namespace: biological_process +def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf, UniProtKB-KW:KW-1116, VZ:820] +synonym: "inhibition of host MHC class II molecule presentation by virus" RELATED [UniProtKB-KW:KW-1116] +xref: VZ:820 "Inhibition of host MHC class II molecule presentation by virus" +is_a: GO:0002587 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class II +is_a: GO:0002820 ! negative regulation of adaptive immune response +is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0039506 +name: modulation by virus of host molecular function +namespace: biological_process +def: "The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp] +synonym: "modification by virus of host protein function" EXACT [GOC:bf] +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0052055 ! modulation by symbiont of host molecular function + +[Term] +id: GO:0039507 +name: suppression by virus of host molecular function +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp] +synonym: "down regulation by virus of host protein function" EXACT [GOC:bf] +synonym: "down-regulation by virus of host protein function" EXACT [GOC:bf] +synonym: "inhibition by virus of host protein function" NARROW [GOC:bf] +synonym: "inhibition of host protein function" NARROW [GOC:bf] +synonym: "negative regulation by virus of host molecular function" EXACT [GOC:bf] +synonym: "negative regulation by virus of host protein function" EXACT [GOC:bf] +is_a: GO:0039516 ! modulation by virus of host catalytic activity +is_a: GO:0052053 ! negative regulation by symbiont of host catalytic activity + +[Term] +id: GO:0039508 +name: suppression by virus of host receptor activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp] +synonym: "down-regulation by virus of host receptor activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host receptor activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host receptor activity" NARROW [GOC:bf] +synonym: "negative regulation by virus of host receptor activity" EXACT [GOC:bf] +synonym: "suppression by virus of host receptor function" EXACT [GOC:bf] +synonym: "viral inhibition of host receptor" EXACT [GOC:bf] +is_a: GO:0039507 ! suppression by virus of host molecular function + +[Term] +id: GO:0039509 +name: suppression by virus of host pattern recognition receptor activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp] +synonym: "down regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] +synonym: "down-regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host pattern recognition receptor activity" NARROW [GOC:rf] +synonym: "negative regulation by virus of host pattern recognition receptor activity" EXACT [GOC:bf] +synonym: "suppression by virus of host pattern recognition receptor function" EXACT [GOC:bf] +synonym: "viral inhibition of host pattern recognition receptor activity" NARROW [GOC:bf] +is_a: GO:0039508 ! suppression by virus of host receptor activity + +[Term] +id: GO:0039510 +name: obsolete suppression by virus of host ATP-dependent RNA helicase activity +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity." [GOC:bf, GOC:sp] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down-regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host ATP-dependent RNA helicase activity" NARROW [GOC:bf] +synonym: "negative regulation by virus of host ATP-dependent RNA helicase activity" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039511 +name: suppression by virus of host interferon receptor activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843] +synonym: "down-regulation by virus of host interferon receptor activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host interferon receptor activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host interferon receptor activity" NARROW [GOC:bf] +synonym: "inhibition of host interferon receptors by virus" EXACT [UniProtKB-KW:KW-1091] +synonym: "negative regulation by virus of host interferon receptor activity" EXACT [GOC:bf] +xref: VZ:843 "Inhibition of host interferon receptors by virus" +is_a: GO:0039508 ! suppression by virus of host receptor activity + +[Term] +id: GO:0039512 +name: suppression by virus of host protein tyrosine kinase activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity." [GOC:bf, GOC:sp] +synonym: "down-regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host protein tyrosine kinase activity" NARROW [GOC:bf] +synonym: "negative regulation by virus of host protein tyrosine kinase activity" EXACT [GOC:bf] +is_a: GO:0039584 ! suppression by virus of host protein kinase activity + +[Term] +id: GO:0039513 +name: suppression by virus of host catalytic activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity." [GOC:bf] +synonym: "down-regulation by virus of host enzyme activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host catalytic activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host catalytic activity" NARROW [GOC:bf] +synonym: "negative regulation by virus of host catalytic activity" EXACT [GOC:bf] +is_a: GO:0039507 ! suppression by virus of host molecular function + +[Term] +id: GO:0039514 +name: suppression by virus of host JAK-STAT cascade +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism." [GOC:bf, GOC:sp] +synonym: "down-regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] +synonym: "downregulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] +synonym: "inhibition by virus of host JAK-STAT cascade" NARROW [GOC:bf] +synonym: "negative regulation by virus of host JAK-STAT cascade" EXACT [GOC:bf] +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway + +[Term] +id: GO:0039516 +name: modulation by virus of host catalytic activity +namespace: biological_process +def: "The process in which a virus effects a change in host enzyme activity." [GOC:bf, GOC:sp] +synonym: "modulation of catalytic activity of host by virus" EXACT [GOC:bf] +synonym: "regulation by virus of host catalytic activity" EXACT [GOC:bf] +synonym: "regulation of host catalytic activity by virus" EXACT [GOC:bf] +is_a: GO:0039506 ! modulation by virus of host molecular function +is_a: GO:0052148 ! modulation by symbiont of host catalytic activity + +[Term] +id: GO:0039517 +name: modulation by virus of host protein serine/threonine phosphatase activity +namespace: biological_process +def: "The process in which a virus effects a change in host protein serine/threonine phosphatase activity." [GOC:bf, GOC:sp] +synonym: "modulation by virus of protein serine/threonine phosphatase activity in host" EXACT [GOC:bf] +synonym: "regulation by virus of host protein serine/threonine phosphatase activity" EXACT [GOC:bf] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0039516 ! modulation by virus of host catalytic activity + +[Term] +id: GO:0039518 +name: suppression by virus of host cytokine activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity." [GOC:bf, GOC:sp] +synonym: "down-regulation by virus of host cytokine activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host cytokine activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host cytokine activity" NARROW [GOC:bf] +synonym: "negative regulation by virus of host cytokine activity" EXACT [GOC:bf] +is_a: GO:0039507 ! suppression by virus of host molecular function + +[Term] +id: GO:0039519 +name: modulation by virus of host autophagy +namespace: biological_process +def: "Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp] +synonym: "regulation by virus of host autophagy" EXACT [GOC:bf] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +is_a: GO:0075071 ! modulation by symbiont of host autophagy +is_a: GO:1904092 ! regulation of autophagic cell death + +[Term] +id: GO:0039520 +name: induction by virus of host autophagy +namespace: biological_process +def: "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846] +synonym: "activation of host autophagy by virus" EXACT [UniProtKB-KW:KW-1072] +synonym: "positive regulation by virus of host autophagy" BROAD [GOC:bf] +xref: VZ:846 "Activation of host autophagy by virus" +is_a: GO:0010508 ! positive regulation of autophagy +is_a: GO:0039519 ! modulation by virus of host autophagy +is_a: GO:0075044 ! positive regulation by symbiont of host autophagy + +[Term] +id: GO:0039521 +name: suppression by virus of host autophagy +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1083, VZ:845] +synonym: "inhibition by virus of host autophagy" EXACT [GOC:bf] +synonym: "inhibition of host autophagy by virus" EXACT [UniProtKB-KW:KW-1083] +synonym: "negative regulation by virus of host autophagy" BROAD [GOC:bf] +xref: VZ:845 "Inhibition of host autophagy by virus" +is_a: GO:0010507 ! negative regulation of autophagy +is_a: GO:0039519 ! modulation by virus of host autophagy +is_a: GO:0140321 ! negative regulation by symbiont of host autophagy + +[Term] +id: GO:0039522 +name: suppression by virus of host mRNA export from nucleus +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1099, VZ:902] +synonym: "inhibition by virus of host mRNA nuclear export" EXACT [GOC:bf] +synonym: "inhibition of host mRNA nuclear export by virus" EXACT [UniProtKB-KW:KW-1099] +synonym: "negative regulation by virus of host mRNA nuclear export" BROAD [GOC:bf] +synonym: "suppression of host mRNA nuclear export by virus" EXACT [GOC:bf] +xref: VZ:902 "Inhibition of host mRNA nuclear export by virus" +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0052038 ! modulation by symbiont of host intracellular transport + +[Term] +id: GO:0039523 +name: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity." [GOC:bf, GOC:sp, PMID:25233083] +synonym: "inhibition of host RNA polymerase II activity by virus" EXACT [GOC:bf] +synonym: "inhibition of host RNA polymerase II by virus" EXACT [] +synonym: "negative regulation by virus of host RNA polymerase II activity" BROAD [GOC:bf] +synonym: "suppression by virus of host RNA polymerase II activity" EXACT [] +is_a: GO:0039653 ! suppression by virus of host transcription + +[Term] +id: GO:0039524 +name: suppression by virus of host mRNA processing +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1103, VZ:903] +synonym: "inhibition by virus of host mRNA processing" EXACT [GOC:bf] +synonym: "inhibition of host mRNA processing by virus" EXACT [GOC:bf] +synonym: "inhibition of host pre-mRNA processing by virus" EXACT [UniProtKB-KW:KW-1103, VZ:903] +synonym: "negative regulation by virus of host mRNA processing" BROAD [GOC:bf] +xref: VZ:903 "Inhibition of host pre-mRNA processing by virus" +is_a: GO:0039657 ! suppression by virus of host gene expression +is_a: GO:0046778 ! modification by virus of host mRNA processing +is_a: GO:0050686 ! negative regulation of mRNA processing + +[Term] +id: GO:0039525 +name: modulation by virus of host chromatin organization +namespace: biological_process +def: "Any process in which a virus effects a change in the organization of chromatin in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1122] +synonym: "modulation by virus of host chromatin organisation" EXACT [GOC:mah] +synonym: "modulation of host chromatin by virus" EXACT [UniProtKB-KW:KW-1122] +synonym: "modulation of host chromatin structure by virus" EXACT [GOC:bf] +synonym: "regulation by virus of host chromatin organization" RELATED [GOC:bf] +is_a: GO:0019054 ! modulation by virus of host cellular process +relationship: regulates GO:0006325 ! chromatin organization + +[Term] +id: GO:0039526 +name: modulation by virus of host apoptotic process +namespace: biological_process +def: "Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells." [GOC:bf, GOC:mtg_apoptosis, GOC:sp, UniProtKB-KW:KW-1119] +synonym: "modulation by virus of host apoptosis" EXACT [] +synonym: "modulation of host cell apoptosis by virus" EXACT [UniProtKB-KW:KW-1119] +synonym: "regulation by virus of host apoptosis" EXACT [GOC:bf] +xref: VZ:1581 "Apoptosis modulation" +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0052150 ! modulation by symbiont of host apoptotic process + +[Term] +id: GO:0039527 +name: suppression by virus of host TRAF-mediated signal transduction +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host." [GOC:bf, GOC:sp] +synonym: "inhibition of host TRAF-mediated signal transduction by virus" EXACT [GOC:bf] +synonym: "negative regulation by virus of host TRAF-mediated signal transduction" BROAD [GOC:bf] +synonym: "suppression by virus of host tumor necrosis factor receptor-associated factor signaling" EXACT [GOC:bf] +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway + +[Term] +id: GO:0039528 +name: cytoplasmic pattern recognition receptor signaling pathway in response to virus +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363] +comment: This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2. +synonym: "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW [PMID:17328678] +synonym: "cytoplasmic pattern recognition receptor signalling pathway in response to virus" EXACT [GOC:mah] +synonym: "RIG-I-like receptor (RLR) signaling pathway" NARROW [PMID:21626883] +synonym: "RIG-I/MDA5 signaling pathway" NARROW [PMID:21187438] +synonym: "RIG-like helicase signaling pathway" NARROW [PMID:18272355] +synonym: "RIG-like receptor signaling pathway" NARROW [PMID:19531363] +synonym: "RLH signaling pathway" NARROW [PMID:18272355] +synonym: "RLR signaling pathway" NARROW [PMID:19531363] +synonym: "virus-induced cytoplasmic pattern recognition receptor signaling pathway" EXACT [GOC:bf] +is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway +is_a: GO:0098586 ! cellular response to virus +relationship: part_of GO:0051607 ! defense response to virus + +[Term] +id: GO:0039529 +name: RIG-I signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580] +comment: The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect. +synonym: "DDX58 signaling pathway" EXACT [HGNC:19102] +synonym: "retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] +synonym: "RIG-I signalling pathway" EXACT [GOC:mah] +is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus + +[Term] +id: GO:0039530 +name: MDA-5 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:19620789] +synonym: "IFIH1 signaling pathway" EXACT [HGNC:18873] +synonym: "MDA-5 signalling pathway" EXACT [GOC:mah] +synonym: "MDA5 signaling pathway" NARROW [PMID:17328678] +synonym: "melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] +is_a: GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus + +[Term] +id: GO:0039531 +name: regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl] +synonym: "regulation of MAV signaling" RELATED [GOC:bf, GOC:sp] +synonym: "regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus + +[Term] +id: GO:0039532 +name: negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl] +synonym: "negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf] +synonym: "negative regulation of MAVS signaling" RELATED [GOC:bf] +synonym: "negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +is_a: GO:0050687 ! negative regulation of defense response to virus +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0039528 ! cytoplasmic pattern recognition receptor signaling pathway in response to virus + +[Term] +id: GO:0039533 +name: regulation of MDA-5 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl] +synonym: "regulation of IFIH1 signaling pathway" EXACT [HGNC:18873] +synonym: "regulation of MDA-5 signalling pathway" EXACT [GOC:mah] +synonym: "regulation of MDA5 signaling pathway" EXACT [PMID:17328678] +synonym: "regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] +is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +relationship: regulates GO:0039530 ! MDA-5 signaling pathway + +[Term] +id: GO:0039534 +name: negative regulation of MDA-5 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl] +synonym: "negative regulation of IFIH1 signaling pathway" EXACT [HGNC:18873] +synonym: "negative regulation of MDA-5 signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of MDA5 signaling pathway" EXACT [PMID:17328678] +synonym: "negative regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [HGNC:18873] +is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +is_a: GO:0039533 ! regulation of MDA-5 signaling pathway +relationship: negatively_regulates GO:0039530 ! MDA-5 signaling pathway + +[Term] +id: GO:0039535 +name: regulation of RIG-I signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl] +synonym: "regulation of DDX58 signaling pathway" EXACT [HGNC:19102] +synonym: "regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] +synonym: "regulation of RIG-I signalling pathway" EXACT [GOC:mah] +is_a: GO:0039531 ! regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +relationship: regulates GO:0039529 ! RIG-I signaling pathway + +[Term] +id: GO:0039536 +name: negative regulation of RIG-I signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl] +synonym: "negative regulation of DDX58 signaling pathway" EXACT [HGNC:19102] +synonym: "negative regulation of retinoic acid inducible gene I signaling pathway" EXACT [HGNC:19102] +synonym: "negative regulation of RIG-I signalling pathway" EXACT [GOC:mah] +is_a: GO:0039532 ! negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +is_a: GO:0039535 ! regulation of RIG-I signaling pathway +relationship: negatively_regulates GO:0039529 ! RIG-I signaling pathway + +[Term] +id: GO:0039537 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl] +synonym: "suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus" EXACT [GOC:bf] +synonym: "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf] +synonym: "suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf] +synonym: "suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf] +synonym: "suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf] +synonym: "suppression by virus of host RLR signaling pathway" RELATED [GOC:bf] +synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0039503 ! suppression by virus of host innate immune response +is_a: GO:0075111 ! suppression by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0039540 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity +namespace: biological_process +alt_id: GO:0039538 +def: "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19454348, PMID:26138103] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I). +synonym: "inhibition by virus of host DDX58 activity" RELATED [GOC:sp] +synonym: "inhibition by virus of host RIG-I" RELATED [] +synonym: "inhibition by virus of host RIG-I signaling" RELATED [] +synonym: "inhibition of host DDX58/RIG-I by virus" EXACT [] +synonym: "suppression by virus of host DDX58 signaling pathway" RELATED [] +synonym: "suppression by virus of host RIG-I activity" RELATED [] +synonym: "suppression by virus of host RIG-I signaling pathway" RELATED [] +synonym: "suppression by virus of host RIG-I signalling pathway" EXACT [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039541 +name: obsolete suppression by virus of host RIG-I via RIG-I binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by binding to RIG-I itself." [PMID:19193793, PMID:20007272, VZ:856] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of host DDX58:MAVS binding" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039542 +name: obsolete suppression by virus of host RIG-I K63-linked ubiquitination +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity." [PMID:19454348, PMID:21890623] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of host DDX58 K63-linked ubiquitination" EXACT [GOC:bf] +synonym: "inhibition by virus of host RIG-I activity by inhibition of RIG-I ubiquitination" BROAD [GOC:bf] +synonym: "inhibition by virus of TRIM25-mediated ubiquitination of host RIG-I" EXACT [PMID:19454348] +is_obsolete: true + +[Term] +id: GO:0039543 +name: obsolete suppression by virus of host RIG-I activity by viral RNA 5' processing +namespace: biological_process +def: "OBSOLETE. The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition." [PMID:18446221, VZ:856] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host RIG-I activity by inhibition of RNA binding" NARROW [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039544 +name: obsolete suppression by virus of host RIG-I activity by RIG-I proteolysis +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction." [PMID:19628239] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "cleavage of RIG-I by viral proteinase" EXACT [PMID:19628239] +synonym: "inhibition by virus of host RIG-I activity by RIG-I proteolysis" RELATED [VZ:856] +is_obsolete: true + +[Term] +id: GO:0039545 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [PMID:17438296, PMID:22674996] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition of host MAVS by virus" RELATED [] +synonym: "suppression by virus of host MAVS activity" RELATED [] +synonym: "suppression by virus of host mitochondrial antiviral-signaling protein" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039546 +name: obsolete suppression by virus of host MAVS activity by MAVS proteolysis +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling." [PMID:21436888, PMID:22238314] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "viral protease cleavage of MAVS" EXACT [PMID:22238314] +is_obsolete: true + +[Term] +id: GO:0039547 +name: suppression by virus of host TRAF activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components." [GOC:bf, UniProtKB-KW:KW-1110, VZ:715] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition of host TRAFs by virus" EXACT [UniProtKB-KW:KW-1110] +is_a: GO:0039507 ! suppression by virus of host molecular function +relationship: part_of GO:0039527 ! suppression by virus of host TRAF-mediated signal transduction + +[Term] +id: GO:0039548 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition of host IRF3 by virus" RELATED [] +synonym: "inhibition of IRF3-dependent antiviral response" RELATED [PMID:19125153] +synonym: "suppression by virus of host interferon regulatory factor 3" RELATED [] +synonym: "suppression by virus of host IRF3 activity" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039549 +name: obsolete suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes." [PMID:11124948, PMID:12829834, PMID:20631144, PMID:9566918] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition of phosphorylation-induced activation of host IRF3" RELATED [PMID:11124948] +synonym: "inhibition of virus-induced IRF-3 phosphorylation" BROAD [PMID:12829834] +is_obsolete: true + +[Term] +id: GO:0039550 +name: obsolete suppression by virus of host IRF3 activity by inhibition of DNA binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites." [PMID:21632562] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of host IRF3-DNA binding" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039551 +name: obsolete suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome." [VZ:757] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "promotion by virus of proteosome-dependent IRF3 degradation" EXACT [VZ:757] +is_obsolete: true + +[Term] +id: GO:0039552 +name: RIG-I binding +namespace: molecular_function +def: "Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA." [GOC:bf, PMID:21233210] +synonym: "DDX58 binding" EXACT [GOC:sp] +synonym: "DDX58/RIG-I binding" EXACT [GOC:sp] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0039553 +name: suppression by virus of host chemokine activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813] +synonym: "down-regulation by virus of host chemokine activity" EXACT [GOC:bf] +synonym: "downregulation by virus of host chemokine activity" EXACT [GOC:bf] +synonym: "inhibition by virus of host chemokine activity" NARROW [GOC:bf] +synonym: "inhibition of host chemokines by virus" NARROW [UniProtKB-KW:KW-1086] +synonym: "negative regulation by virus of host chemokine activity" EXACT [GOC:bf] +xref: VZ:813 "Inhibition of host chemokines by virus" +is_a: GO:0039518 ! suppression by virus of host cytokine activity + +[Term] +id: GO:0039554 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity +namespace: biological_process +alt_id: GO:0039539 +def: "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [PMID:19019954, PMID:33727702] +synonym: "inhibition by virus of host MDA-5 signaling" RELATED [] +synonym: "inhibition of host IFIH1/MDA5 by virus" RELATED [] +synonym: "Inhibition of host MDA5 by virus" RELATED [] +synonym: "suppression by virus of host IFIH1 signaling pathway" RELATED [] +synonym: "suppression by virus of host MDA-5 activity" RELATED [] +synonym: "suppression by virus of host MDA-5 signaling pathway" RELATED [] +synonym: "suppression by virus of host MDA-5 signalling pathway" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039555 +name: obsolete suppression by virus of host MDA-5 activity via MDA-5 binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by binding to MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector." [PMID:19019954, VZ:603] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host MDA5 activity by MDA-5 binding" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039556 +name: MDA-5 binding +namespace: molecular_function +def: "Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA." [PMID:19019954] +synonym: "MDA5 binding" EXACT [GOC:bf] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0039557 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:11943871, PMID:16014964, PMID:19557165] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition of host interferon regulatory factor-7 by virus" RELATED [] +synonym: "inhibition of host IRF7 by virus" RELATED [] +synonym: "suppression by virus of host interferon regulatory factor 7 activity" RELATED [] +synonym: "suppression by virus of host IRF7 activity" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039558 +name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity." [PMID:18635538, PMID:19694547, VZ:653] +comment: The reason for obsoleting is that the term is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "promotion of IRF-7 SUMOylation" EXACT [PMID:19694547] +synonym: "suppression by virus of host interferon regulatory factor-7 activity by positive regulation of IRF7 sumoylation" RELATED [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039559 +name: obsolete suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome." [PMID:17301153, VZ:653] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "promotion by virus of proteosome-dependent IRF7 degradation" EXACT [VZ:653] +is_obsolete: true + +[Term] +id: GO:0039560 +name: suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [PMID:10388655, PMID:19109390] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition of host interferon regulatory factor-9 by virus" EXACT [GOC:bf] +synonym: "inhibition of host IRF9 by virus" EXACT [] +synonym: "suppression by virus of host interferon regulatory factor 9 activity" RELATED [] +synonym: "suppression by virus of host IRF9 activity" RELATED [] +is_a: GO:0039503 ! suppression by virus of host innate immune response +is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade + +[Term] +id: GO:0039561 +name: obsolete suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism." [PMID:19109390] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host IRF9 activity by nuclear localization of IRF9" RELATED [PMID:19109390] +synonym: "suppression of interferon signaling by nuclear accumulation of IRF9" RELATED [PMID:19109390] +is_obsolete: true + +[Term] +id: GO:0039562 +name: suppression by virus of host JAK-STAT cascade via inhibition of STAT activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition by virus of host STAT activity" NARROW [GOC:bf] +synonym: "suppression by virus of host signal transducer and activator of transcription activity" EXACT [GOC:bf] +synonym: "suppression by virus of host STAT activity" EXACT [] +is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade + +[Term] +id: GO:0039563 +name: suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1)." [PMID:32699158] +comment: This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. +synonym: "inhibition by virus of host STAT1 activity" NARROW [GOC:bf] +synonym: "inhibition of host STAT1 by virus" NARROW [] +synonym: "suppression by virus of host STAT1 activity" RELATED [] +is_a: GO:0039562 ! suppression by virus of host JAK-STAT cascade via inhibition of STAT activity + +[Term] +id: GO:0039564 +name: suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2)." [PMID:32699158] +synonym: "inhibition by virus of host STAT2 activity" RELATED [GOC:bf] +synonym: "inhibition of host STAT2 by virus" RELATED [] +synonym: "suppression by virus of host STAT2 activity" RELATED [] +is_a: GO:0039562 ! suppression by virus of host JAK-STAT cascade via inhibition of STAT activity + +[Term] +id: GO:0039565 +name: obsolete suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome." [PMID:15280488, PMID:16227264, VZ:282] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "promotion by virus of proteosome-dependent STAT1 degradation" EXACT [] +synonym: "suppression by virus of host STAT1 activity by positive promotion of STAT1 proteasome-mediated degradation" EXACT [GOC:bf] +synonym: "targeting STAT1 for proteasome-mediated degradation" EXACT [VZ:282] +is_obsolete: true + +[Term] +id: GO:0039566 +name: obsolete suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1 +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation." [PMID:11238845, PMID:21362620, VZ:282] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host STAT1 activity by peptidyl-tyrosine dephosphorylation of STAT1" EXACT [GOC:bf] +synonym: "viral tyrosine phosphatase activity involved in suppression of host STAT1" RELATED [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039567 +name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668, PMID:16254375, PMID:17287281] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "cytoplasmic sequestration of STAT1" BROAD [PMID:14557668] +synonym: "suppression by virus of host STAT1 activity by cytoplasmic sequestering of STAT1" EXACT [PMID:14557668] +is_obsolete: true + +[Term] +id: GO:0039568 +name: obsolete suppression by virus of host STAT1 activity by inhibition of DNA binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus." [PMID:17287281] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition of DNA binding of STAT1" EXACT [PMID:17287281] +synonym: "suppression by virus of host STAT1 activity by negative regulation of DNA binding" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039569 +name: obsolete suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome." [PMID:11336548, PMID:17251292, PMID:19279106, VZ:257] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "promotion by virus of proteosome-dependent STAT2 degradation" EXACT [] +synonym: "suppression by virus of host STAT2 activity by positive promotion of STAT2 proteasome-mediated degradation" EXACT [GOC:bf] +synonym: "targeting STAT2 for proteasome-mediated degradation" EXACT [VZ:257] +is_obsolete: true + +[Term] +id: GO:0039570 +name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "cytoplasmic sequestering of STAT2" EXACT [GOC:bf] +synonym: "cytoplasmic sequestration of STAT2" EXACT [PMID:14557668] +is_obsolete: true + +[Term] +id: GO:0039571 +name: obsolete suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation." [PMID:12804771] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of tyrosine phosphorylation of STAT1" RELATED [PMID:12804771] +is_obsolete: true + +[Term] +id: GO:0039572 +name: obsolete suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation." [PMID:12804771] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of tyrosine phosphorylation of STAT2" EXACT [PMID:12804771] +is_obsolete: true + +[Term] +id: GO:0039573 +name: suppression by virus of host complement activation +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase." [PMID:21191012, PMID:7745740, UniProtKB-KW:KW-1087, VZ:811] +synonym: "inhibition of host complement activation by virus" EXACT [GOC:bf] +synonym: "inhibition of host complement cascade by virus" EXACT [GOC:bf] +synonym: "inhibition of host complement factors by virus" BROAD [UniProtKB-KW:KW-1087] +xref: VZ:811 "Inhibition of host complement factors by virus" +is_a: GO:0030683 ! mitigation of host immune response by virus +is_a: GO:0045916 ! negative regulation of complement activation +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0075528 ! modulation by virus of host immune response + +[Term] +id: GO:0039574 +name: suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits." [PMID:16987978, PMID:19085955] +synonym: "suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity" EXACT [] +synonym: "suppression by virus of host TYK2 activity" RELATED [] +is_a: GO:0039503 ! suppression by virus of host innate immune response +is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade + +[Term] +id: GO:0039575 +name: obsolete suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2." [PMID:10523853, PMID:16987978, PMID:19254804] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "inhibition by virus of host TYK2 activation" BROAD [GOC:bf, PMID:19254804] +synonym: "inhibition by virus of host TYK2 phosphorylation" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039576 +name: suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity +namespace: biological_process +alt_id: GO:0039515 +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1)." [PMID:16188985] +synonym: "inhibition of host JAK activity by virus" NARROW [GOC:bf] +synonym: "negative regulation by virus of host JAK" EXACT [GOC:bf] +synonym: "negative regulation by virus of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] +synonym: "suppression by virus of host JAK1 activity" EXACT [] +synonym: "suppression by virus of host janus kinase 1 activity" EXACT [PR:000009196] +synonym: "suppression by virus of tyrosine phosphorylation of host STAT protein" NARROW [] +synonym: "viral inhibition of tyrosine phosphorylation of host STAT protein" NARROW [GOC:bf] +xref: VZ:784 "Inhibition of host JAK1 by virus" +is_a: GO:0039514 ! suppression by virus of host JAK-STAT cascade + +[Term] +id: GO:0039577 +name: obsolete suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1." [PMID:12620806] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +is_obsolete: true + +[Term] +id: GO:0039578 +name: obsolete suppression by virus of host JAK1 activity via JAK1 binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive." [PMID:9448289] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +is_obsolete: true + +[Term] +id: GO:0039579 +name: suppression by virus of host ISG15-protein conjugation +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives." [PMID:11157743, PMID:18604270] +synonym: "suppression by virus of host ISG15 activity" RELATED [] +is_a: GO:0039503 ! suppression by virus of host innate immune response + +[Term] +id: GO:0039580 +name: suppression by virus of host PKR signaling +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response." [PMID:15207627] +synonym: "suppression by virus of host EIF2AK2 activity" NARROW [] +synonym: "suppression by virus of host PKR activity" NARROW [] +is_a: GO:0019057 ! modulation by virus of host translation +is_a: GO:0039503 ! suppression by virus of host innate immune response + +[Term] +id: GO:0039581 +name: obsolete suppression by virus of host PKR activity via double-stranded RNA binding +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by binding to double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding." [PMID:7514679] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host PKR activity by binding to dsRNA" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039582 +name: obsolete suppression by virus of host PKR activity by positive regulation of PKR nuclear localization +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha)." [PMID:16987971] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "suppression by virus of host PKR activity by nuclear sequestration of PKR" EXACT [GOC:bf] +synonym: "suppression by virus of host PKR activity by positive regulation of PKR localization to nucleus" EXACT [GOC:bf] +synonym: "suppression by virus of host PKR activity by sequestering of PKR in nucleus" EXACT [PMID:16987971] +is_obsolete: true + +[Term] +id: GO:0039583 +name: obsolete suppression by virus of host PKR activity by positive regulation of PKR catabolic process +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes." [PMID:19751406] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "downregulation of PKR by degradation through proteosome" EXACT [PMID:19751406] +synonym: "promotion by virus of proteosome-dependent PKR degradation" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039584 +name: suppression by virus of host protein kinase activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." [GOC:bf] +is_a: GO:0039513 ! suppression by virus of host catalytic activity +is_a: GO:0039613 ! suppression by virus of host protein phosphorylation +is_a: GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0039585 +name: PKR-mediated signaling +namespace: biological_process +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:27629041, PMID:9843495, VZ:1576] +synonym: "EIF2AK3 signal transduction" EXACT [] +synonym: "EIF2AK3/PERK signaling" EXACT [] +synonym: "PKR signal transduction" EXACT [] +synonym: "PKR signaling pathway" EXACT [PMID:22102852] +synonym: "signaling through PKR" EXACT [GOC:bf] +is_a: GO:0035556 ! intracellular signal transduction +is_a: GO:0140467 ! integrated stress response signaling + +[Term] +id: GO:0039586 +name: modulation by virus of host PP1 activity +namespace: biological_process +def: "The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response." [UniProtKB-KW:KW-1126, VZ:803] +synonym: "modulation of host PP1 activity by virus" EXACT [UniProtKB-KW:KW-1126] +synonym: "regulation by virus of host PP1 activity" EXACT [GOC:bf] +xref: VZ:803 "Modulation of host PP1 activity by virus" +is_a: GO:0039517 ! modulation by virus of host protein serine/threonine phosphatase activity + +[Term] +id: GO:0039587 +name: suppression by virus of host tetherin activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439] +synonym: "inhibition of host BST2/Tetherin by virus" EXACT [] +is_a: GO:0019049 ! mitigation of host defenses by virus + +[Term] +id: GO:0039588 +name: suppression by virus of host antigen processing and presentation +namespace: biological_process +def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex." [UniProtKB-KW:KW-1117, VZ:815] +synonym: "inhibition of host proteasome antigen processing by virus" EXACT [UniProtKB-KW:KW-1117] +xref: VZ:815 "Inhibition of host proteasome antigen processing by virus" +is_a: GO:0039504 ! suppression by virus of host adaptive immune response + +[Term] +id: GO:0039589 +name: obsolete suppression by virus of host TAP complex +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817] +comment: This term was obsoleted because this type of process is now represented by the actual function inhibited. +synonym: "inhibition of host TAP by virus" EXACT [UniProtKB-KW:KW-1107] +xref: VZ:817 "Inhibition of host TAP by virus" +is_obsolete: true +consider: GO:0039588 + +[Term] +id: GO:0039592 +name: suppression by virus of G2/M transition of host mitotic cell cycle +namespace: biological_process +def: "Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle." [UniProtKB-KW:KW-1079, VZ:876] +synonym: "host G2/M cell cycle arrest by virus" EXACT [UniProtKB-KW:KW-1079] +xref: VZ:876 "Host G2/M cell cycle arrest by virus" +is_a: GO:0060153 ! modulation by virus of host cell cycle + +[Term] +id: GO:0039593 +name: suppression by virus of host exit from mitosis +namespace: biological_process +def: "Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [UniProtKB-KW:KW-1098, VZ:877] +synonym: "inhibition of host mitotic exit by virus" EXACT [UniProtKB-KW:KW-1098, VZ:877] +xref: VZ:877 "Inhibition of host mitotic exit by virus" +is_a: GO:0060153 ! modulation by virus of host cell cycle + +[Term] +id: GO:0039594 +name: endoribonuclease activity involved in viral induction of host mRNA catabolic process +namespace: molecular_function +def: "Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA." [GOC:bf, PMID:22046136] +comment: GO:0039594 can be used to annotate a host or viral endoribonuclease activity that cleaves host mRNA in response to a viral infection. +is_a: GO:0004521 ! endoribonuclease activity + +[Term] +id: GO:0039595 +name: induction by virus of catabolism of host mRNA +namespace: biological_process +def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA)." [GOC:bf, UniProtKB-KW:KW-1132] +synonym: "induction by virus of host mRNA catabolic process" EXACT [GOC:bf] +synonym: "induction of host mRNA decay" EXACT [VZ:901] +synonym: "promotion of host mRNA degradation" EXACT [] +synonym: "viral induction of host mRNA decay" EXACT [GOC:bf] +synonym: "virus-mediated mRNA decay" EXACT [VZ:901] +xref: VZ:901 "Virus-mediated host mRNA decay" +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0039656 ! modulation by virus of host gene expression +is_a: GO:0061014 ! positive regulation of mRNA catabolic process + +[Term] +id: GO:0039596 +name: modulation by virus of host protein dephosphorylation +namespace: biological_process +def: "Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein." [GOC:bf] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0035304 ! regulation of protein dephosphorylation + +[Term] +id: GO:0039597 +name: obsolete induction by virus of host endoribonuclease activity +namespace: biological_process +def: "OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity." [PMID:22174690] +comment: This term was obsoleted because it represents a molecular function. +synonym: "viral induction of host RNAse activity" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039598 +name: obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process +namespace: biological_process +def: "OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:sp] +comment: This term was made obsolete because it is unclear what role the viral protein is playing in this process. and there is insufficient evidence to use this term for annotation. +synonym: "induction by virus of host nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] +synonym: "induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process" EXACT [] +synonym: "virus-mediated host mRNA decay by hyperadenylation" NARROW [GOC:sp] +is_obsolete: true + +[Term] +id: GO:0039599 +name: cleavage by virus of host mRNA +namespace: biological_process +def: "Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease." [PMID:22046136] +synonym: "host mRNA cleavage by viral endoribonuclease" EXACT [GOC:bf] +synonym: "viral endoribonuclease activity involved in degradation of host mRNA" RELATED [GOC:bf] +is_a: GO:0019048 ! modulation by virus of host process + +[Term] +id: GO:0039600 +name: induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process +namespace: biological_process +def: "The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends." [GOC:bf, PMID:22174690] +comment: Some viruses utilize a host RNase to induce endonucleolytic cleavage of template mRNAs (e.g. the NSP1 protein of SARS coronavirus); for these consider instead annotating to the child term 'induction by virus of host endoribonuclease activity ; GO:0039597'. Other viral proteins act as endonucleases themselves to cleave mRNA and then rely on the host degradation machinery to clear the resulting fragments (e.g. gamma herpesvirus SOX protein); for these cases consider instead annotating to the child term 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'. +synonym: "induction by virus of host endonucleolytic cleavage-dependent mRNA decay" EXACT [GOC:bf] +synonym: "induction by virus of host nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [GOC:bf] +is_a: GO:0039595 ! induction by virus of catabolism of host mRNA + +[Term] +id: GO:0039602 +name: suppression by virus of host transcription initiation from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:0039601 +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [UniProtKB-KW:KW-1111, VZ:904] +synonym: "inhibition of host transcription initiation by virus" EXACT [GOC:bf] +synonym: "suppression by virus of host DNA-dependent transcription, initiation" EXACT [] +xref: VZ:904 "Inhibition of host transcription initiation by virus" +is_a: GO:0039653 ! suppression by virus of host transcription + +[Term] +id: GO:0039603 +name: obsolete TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter +namespace: molecular_function +def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:11968006] +comment: The reason for obsoletion is that the term is too specific, and the paper referenced in the term should instead be annotated to GO:0039602 ; suppression by virus of host transcription initiation from RNA polymerase II promoter. +is_obsolete: true + +[Term] +id: GO:0039604 +name: suppression by virus of host translation +namespace: biological_process +def: "Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA." [UniProtKB-KW:KW-1193, VZ:1579] +synonym: "host translation shutoff by virus" EXACT [UniProtKB-KW:KW-1193, VZ:1579] +synonym: "viral inhibition of cellular protein synthesis" EXACT [VZ:1579] +synonym: "viral shutoff of host protein synthesis" EXACT [PMID:8643618] +xref: VZ:1579 "Translation shutoff" +is_a: GO:0019057 ! modulation by virus of host translation +is_a: GO:0039657 ! suppression by virus of host gene expression + +[Term] +id: GO:0039605 +name: obsolete TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter +namespace: molecular_function +def: "OBSOLETE. Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:18768974] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +is_obsolete: true + +[Term] +id: GO:0039606 +name: suppression by virus of host translation initiation +namespace: biological_process +def: "Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein." [GOC:bf] +is_a: GO:0039604 ! suppression by virus of host translation + +[Term] +id: GO:0039607 +name: obsolete proteolysis by virus of host translation initiation factor +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds." [PMID:18572216] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +synonym: "cleavage of host translation initiation factor by viral protease" EXACT [GOC:bf] +synonym: "cleavage of host translation initiation factor by virus" RELATED [GOC:sp] +synonym: "proteolytic cleavage by virus of host translation initiation factor" EXACT [GOC:bf] +synonym: "suppression by virus of host translation initiation factor activity by proteolysis" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0039608 +name: obsolete suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation +namespace: biological_process +def: "OBSOLETE. Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein." [PMID:12239292, PMID:8643618] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. +is_obsolete: true + +[Term] +id: GO:0039611 +name: suppression by virus of host translation initiation factor activity +namespace: biological_process +def: "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor." [GOC:bf, UniProtKB-KW:KW-1075] +synonym: "inactivation of eIF2 activity" NARROW [PMID:12239292] +synonym: "inhibition of activity of host translation initiation factor" EXACT [PMID:12239292] +synonym: "Inhibition of host translation factors by virus" BROAD [UniProtKB-KW:KW-1075] +synonym: "suppression by virus of host EIF-4E activity" EXACT [GOC:bf] +is_a: GO:0039507 ! suppression by virus of host molecular function +is_a: GO:0039606 ! suppression by virus of host translation initiation +is_a: GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0039612 +name: modulation by virus of host protein phosphorylation +namespace: biological_process +def: "Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0019054 ! modulation by virus of host cellular process + +[Term] +id: GO:0039613 +name: suppression by virus of host protein phosphorylation +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] +synonym: "viral inhibition of host protein phosphorylation" EXACT [GOC:bf] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0039612 ! modulation by virus of host protein phosphorylation + +[Term] +id: GO:0039614 +name: induction by virus of host protein phosphorylation +namespace: biological_process +def: "Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0039612 ! modulation by virus of host protein phosphorylation + +[Term] +id: GO:0039615 +name: T=1 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [UniProtKB-KW:KW-1140, VZ:1057] +xref: VZ:1057 "T=1 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039616 +name: T=2 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [UniProtKB-KW:KW-1141, VZ:838] +comment: The T=2 symmetry is an non-official appellation; strictly speaking the capsid has a T=1 symmetry with each unit composed of a homodimer. +xref: VZ:838 "T=2 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039617 +name: T=3 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1142, VZ:806] +xref: VZ:806 "T=3 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039618 +name: T=pseudo3 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1143, VZ:809] +comment: T=pseudo3 capsids are not T=3 symmetry as described by Caspar and Klug (PMID:14019094) because the basic unit is composed of three different proteins. Since the three subunits are morphologically very similar, the structure is therefore a pseudo T=3. +xref: VZ:809 "T=pseudo3 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039619 +name: T=4 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [UniProtKB-KW:KW-1144, VZ:808] +xref: VZ:808 "T=4 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039620 +name: T=7 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [UniProtKB-KW:KW-1145, VZ:804] +comment: Spherical viruses with T numbers greater than or equal to 7 are skewed. They are therefore described as either right-handed (dextro) or left-handed (laevo). +xref: VZ:804 "T=7 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039621 +name: T=13 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [UniProtKB-KW:KW-1146, VZ:260] +xref: VZ:260 "T=13 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039622 +name: T=16 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [UniProtKB-KW:KW-1147, VZ:807] +xref: VZ:807 "T=16 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039623 +name: T=25 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [UniProtKB-KW:KW-1148, VZ:810] +xref: VZ:810 "T=25 icosahedral capsid protein" +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039624 +name: viral outer capsid +namespace: cellular_component +def: "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1152] +synonym: "outer capsid" EXACT [GOC:bf] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039625 +name: viral inner capsid +namespace: cellular_component +def: "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1153] +synonym: "inner capsid" EXACT [GOC:bf] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039626 +name: viral intermediate capsid +namespace: cellular_component +def: "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions." [UniProtKB-KW:KW-1154] +synonym: "intermediate capsid" EXACT [GOC:bf] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039627 +name: T=147 icosahedral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins." [GOC:plm, UniProtKB-KW:KW-0167] +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039628 +name: T=169 icosahedral viral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1150] +synonym: "T=169 icosahedral capsid" EXACT [GOC:bf] +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039629 +name: T=219 icosahedral capsid +namespace: cellular_component +def: "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1151] +is_a: GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039630 +name: RNA translocase activity +namespace: molecular_function +def: "Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis." [GOC:bm, PMID:22713318] +comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. +is_a: GO:0008186 ! ATP-dependent activity, acting on RNA + +[Term] +id: GO:0039631 +name: DNA translocase activity involved in viral DNA genome packaging +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid." [GOC:bm, PMID:17501915] +synonym: "viral DNA packaging activity" RELATED [GOC:bm] +synonym: "viral DNA packaging motor activity" RELATED [PMID:17501915] +is_a: GO:0015616 ! DNA translocase activity + +[Term] +id: GO:0039632 +name: RNA translocase activity involved in viral RNA genome packaging +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid." [GOC:bm, PMID:22297533] +synonym: "RNA packaging ATPase activity" EXACT [PMID:22297533] +synonym: "viral RNA packaging activity" RELATED [GOC:bm] +is_a: GO:0039630 ! RNA translocase activity + +[Term] +id: GO:0039633 +name: killing by virus of host cell +namespace: biological_process +def: "Any process mediated by a virus that results in the death of a cell in the host organism." [GOC:bf, GOC:bm, GOC:jl] +synonym: "killing by phage of host cells" NARROW [GOC:bm] +synonym: "killing by virus of host cells" EXACT [] +is_a: GO:0001907 ! killing by symbiont of host cells + +[Term] +id: GO:0039634 +name: killing by virus of host cell during superinfection exclusion +namespace: biological_process +def: "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bf, GOC:bm, GOC:jl, PMID:22398285] +synonym: "killing by virus of host cells during superinfection exclusion" EXACT [] +synonym: "killing by virus of host cells involved in superinfection exclusion" EXACT [GOC:bf] +synonym: "Rex exclusion" NARROW [] +is_a: GO:0009615 ! response to virus +is_a: GO:0039633 ! killing by virus of host cell + +[Term] +id: GO:0039635 +name: suppression by virus of host peptidoglycan biosynthetic process +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, GOC:jl] +synonym: "viral inhibition of host peptidoglycan biosynthesis" RELATED [GOC:bf] +is_a: GO:0039636 ! suppression by virus of host cell wall biogenesis + +[Term] +id: GO:0039636 +name: suppression by virus of host cell wall biogenesis +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts." [GOC:bf, GOC:bm, GOC:jl] +is_a: GO:0019054 ! modulation by virus of host cellular process + +[Term] +id: GO:0039637 +name: catabolism by virus of host DNA +namespace: biological_process +def: "The breakdown of host DNA, deoxyribonucleic acid, by a virus." [GOC:bf, GOC:bm, GOC:jl] +is_a: GO:0019048 ! modulation by virus of host process + +[Term] +id: GO:0039638 +name: lipopolysaccharide-mediated virion attachment to host cell +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface." [GOC:bf, GOC:bm, PMID:12837775] +synonym: "lipopolysaccharide binding involved in viral attachment to host cell" EXACT [GOC:bf, GOC:bm] +synonym: "LPS binding involved in viral attachment to host cell" EXACT [GOC:bf] +synonym: "virion attachment, binding to host lipopolysaccharide" EXACT [GOC:bf, GOC:jl] +is_a: GO:0019062 ! virion attachment to host cell + +[Term] +id: GO:0039639 +name: suppression by virus of host cell lysis in response to superinfection +namespace: biological_process +def: "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373] +synonym: "lysis inhibition" BROAD [GOC:bm, PMID:22389108] +synonym: "suppression by virus of host cell lysis in response to superinfecting virus" EXACT [GOC:bf] +is_a: GO:0001899 ! negative regulation of cytolysis by symbiont of host cells +is_a: GO:0098586 ! cellular response to virus + +[Term] +id: GO:0039640 +name: viral release by cytolysis via suppression of host peptidoglycan biosynthetic process +namespace: biological_process +def: "The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, PMID:28894177] +synonym: "cytolysis by virus via suppression of host peptidoglycan biosynthetic process" RELATED [] +synonym: "viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process" EXACT [] +is_a: GO:0044659 ! viral release from host cell by cytolysis + +[Term] +id: GO:0039641 +name: viral inner membrane +namespace: cellular_component +def: "The lipid bilayer of a virion contained inside the protein capsid." [GOC:bm, PMID:15331712] +synonym: "virion inner membrane" EXACT [GOC:bf, GOC:bm, GOC:jl] +is_a: GO:0036338 ! viral membrane + +[Term] +id: GO:0039642 +name: virion nucleoid +namespace: cellular_component +def: "The region of a virion in which the nucleic acid is confined." [GOC:bm, PMID:14291596] +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0039643 +name: host cell viral nucleoid +namespace: cellular_component +def: "The region of a host cell that contains the viral genome." [GOC:bf, GOC:bm, GOC:jl] +comment: To annotate the region of the complete virus particle in which the viral genome is contained, instead use 'virion nucleoid ; GO:0039642'. +is_a: GO:0033646 ! host intracellular part + +[Term] +id: GO:0039644 +name: suppression by virus of host NF-kappaB cascade +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a host NF-kappaB cascade." [PMID:10920188, PMID:25275128] +synonym: "inhibition of host NF-kappa-B by virus" EXACT [] +synonym: "suppression by virus of host NF-kappaB transcription factor activity" RELATED [] +is_a: GO:0019049 ! mitigation of host defenses by virus +is_a: GO:0019054 ! modulation by virus of host cellular process + +[Term] +id: GO:0039645 +name: modulation by virus of host G1/S transition checkpoint +namespace: biological_process +def: "Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint." [UniProtKB-KW:KW-1078] +synonym: "G1/S host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1078, VZ:880] +xref: VZ:880 "G1/S host cell cycle checkpoint dysregulation by virus" +is_a: GO:0060153 ! modulation by virus of host cell cycle + +[Term] +id: GO:0039646 +name: modulation by virus of host G0/G1 transition checkpoint +namespace: biological_process +def: "Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint." [UniProtKB-KW:KW-1077] +synonym: "G0/G1 host cell cycle checkpoint dysregulation by virus" EXACT [UniProtKB-KW:KW-1077, VZ:881] +xref: VZ:881 "G0/G1 host cell cycle checkpoint dysregulation by virus" +is_a: GO:0060153 ! modulation by virus of host cell cycle + +[Term] +id: GO:0039647 +name: obsolete suppression by virus of host poly(A)-binding protein activity +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation." [UniProtKB-KW:KW-1101] +comment: This term was obsoleted because it represents a molecular function. +synonym: "inhibition of host poly(A)-binding protein by virus" EXACT [UniProtKB-KW:KW-1101] +synonym: "suppression by virus of host PABP activity" EXACT [Wikipedia:Poly(A)-binding_protein] +is_obsolete: true +consider: GO:0039604 + +[Term] +id: GO:0039648 +name: modulation by virus of host protein ubiquitination +namespace: biological_process +def: "Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein." [UniProtKB-KW:KW-1130] +synonym: "modulation of host ubiquitin pathway by virus" RELATED [UniProtKB-KW:KW-1130] +is_a: GO:0019054 ! modulation by virus of host cellular process +relationship: regulates GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0039649 +name: modulation by virus of host ubiquitin-protein ligase activity +namespace: biological_process +def: "The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [UniProtKB-KW:KW-1123] +synonym: "modulation of host E3 ubiquitin ligases by virus" NARROW [UniProtKB-KW:KW-1123] +is_a: GO:0039516 ! modulation by virus of host catalytic activity + +[Term] +id: GO:0039650 +name: suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process." [UniProtKB-KW:KW-1085, VZ:912] +synonym: "inhibition of host caspases by virus" NARROW [UniProtKB-KW:KW-1085, VZ:912] +is_a: GO:0019050 ! suppression by virus of host apoptotic process +is_a: GO:0039513 ! suppression by virus of host catalytic activity +is_a: GO:0043086 ! negative regulation of catalytic activity + +[Term] +id: GO:0039651 +name: induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +def: "Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process." [GOC:mtg_apoptosis, UniProtKB-KW:KW-1073] +synonym: "activation of host caspases by virus" NARROW [UniProtKB-KW:KW-1073] +synonym: "induction by virus of host caspase activity" NARROW [GOC:bf, GOC:jl] +is_a: GO:0019051 ! induction by virus of host apoptotic process + +[Term] +id: GO:0039652 +name: induction by virus of host NF-kappaB cascade +namespace: biological_process +def: "Any process in which a virus starts, promotes, or enhances a host NF-kappaB cascade." [PMID:11907233, PMID:7845680] +synonym: "activation by virus of host NF-kappaB transcription factor activity" RELATED [] +synonym: "activation of host NF-kappa-B by virus" EXACT [UniProtKB-KW:KW-1074] +xref: VZ:841 "Activation of host NF-kappa-B by virus" +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0085033 ! induction by symbiont of host I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0039653 +name: suppression by virus of host transcription +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors." [UniProtKB-KW:KW-1191, VZ:1577] +synonym: "host transcription shutoff by virus" NARROW [UniProtKB-KW:KW-1191, VZ:1577] +synonym: "suppression by virus of host DNA-dependent transcription" EXACT [GOC:bf] +xref: VZ:1577 "Host transcription shutoff by virus" +is_a: GO:0019056 ! modulation by virus of host transcription +is_a: GO:0039657 ! suppression by virus of host gene expression +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0039654 +name: fusion of virus membrane with host endosome membrane +namespace: biological_process +alt_id: GO:0075501 +alt_id: GO:0075517 +def: "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell." [GOC:bf, UniProtKB-KW:KW-1170, VZ:992] +synonym: "fusion of virus membrane with host endosomal membrane" EXACT [UniProtKB-KW:KW-1170, VZ:992] +synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [] +synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane" NARROW [] +synonym: "viral entry into host cell via endocytosis followed by membrane fusion with host endosome" RELATED [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane" RELATED [GOC:bf, GOC:jl] +synonym: "viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane" NARROW [] +synonym: "viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane" NARROW [] +xref: VZ:992 "Fusion of virus membrane with host endosomal membrane" +is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell + +[Term] +id: GO:0039655 +name: obsolete transport of virus in host, cell to cell via plasmodesmata +namespace: biological_process +def: "OBSOLETE. The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell." [UniProtKB-KW:KW-0916, VZ:1018] +synonym: "spread of virus in host, cell to cell via plasmodesmata" RELATED [GOC:bf, GOC:jl] +synonym: "viral movement protein" RELATED [VZ:1018] +xref: VZ:1018 "Viral movement protein" +is_obsolete: true + +[Term] +id: GO:0039656 +name: modulation by virus of host gene expression +namespace: biological_process +def: "The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:bf] +synonym: "regulation by virus of host gene expression" RELATED [GOC:bf] +is_a: GO:0019048 ! modulation by virus of host process +relationship: regulates GO:0010467 ! gene expression + +[Term] +id: GO:0039657 +name: suppression by virus of host gene expression +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [UniProtKB-KW:KW-1190, VZ:1582] +synonym: "host gene expression shutoff by virus" EXACT [UniProtKB-KW:KW-1190, VZ:1582] +xref: VZ:1582 "Host gene expression shutoff by virus" +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0039656 ! modulation by virus of host gene expression + +[Term] +id: GO:0039658 +name: TBK1-IKKE-DDX3 complex +namespace: cellular_component +def: "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3." [PMID:18636090, VZ:719] +synonym: "TBK1-IKBKE-DDX3 complex" EXACT [VZ:719] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0039659 +name: obsolete suppression by virus of host TBK1-IKBKE-DDX3 complex activity +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex." [VZ:719] +comment: The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. See also: suppression by virus of host TBK1 activity; GO:0039723, and suppression by virus of host IKBKE activity; GO:0039724. +synonym: "inhibition of host TBK1-IKBKE-DDX3 complex by virus" EXACT [VZ:719] +synonym: "suppression by virus of host TBK1-IKKE-DDX3 complex activity" EXACT [] +xref: VZ:719 "Inhibition of host TBK1-IKBKE-DDX3 complex by virus" +is_obsolete: true + +[Term] +id: GO:0039660 +name: structural constituent of virion +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a virion." [GOC:bf, GOC:jl] +synonym: "viral matrix protein" NARROW [UniProtKB-KW:KW-0468] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0039661 +name: host organelle outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell." [GOC:bf, GOC:ch] +is_a: GO:0044384 ! host outer membrane + +[Term] +id: GO:0039662 +name: host cell outer membrane +namespace: cellular_component +def: "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell." [GOC:bf, GOC:ch] +synonym: "host cell envelope outer membrane" EXACT [GOC:bf, GOC:ch] +synonym: "outer membrane of host cell" EXACT [GOC:bf, GOC:ch] +is_a: GO:0044384 ! host outer membrane +relationship: part_of GO:0044230 ! host cell envelope + +[Term] +id: GO:0039663 +name: membrane fusion involved in viral entry into host cell +namespace: biological_process +def: "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168] +synonym: "fusion of virus membrane with host membrane" RELATED [UniProtKB-KW:KW-1168] +synonym: "fusion of virus membrane with host membrane during viral entry" RELATED [UniProtKB-KW:KW-1168] +synonym: "viral entry into host cell via membrane fusion" RELATED [GOC:bf, GOC:jl] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0039664 +name: lysis of host organelle involved in viral entry into host cell +namespace: biological_process +def: "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984] +synonym: "viral entry into host cell via endosome membrane lysis" NARROW [VZ:984] +synonym: "viral entry into host cell via lysis of host organelle membrane" RELATED [GOC:bf, GOC:jl] +synonym: "viral membrane-lytic protein" RELATED [UniProtKB-KW:KW-1174] +synonym: "viral penetration via lysis of host organellar membrane" EXACT [UniProtKB-KW:KW-984] +xref: VZ:984 "Viral penetration via lysis of host organellar membrane" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0039665 +name: permeabilization of host organelle membrane involved in viral entry into host cell +namespace: biological_process +def: "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985] +synonym: "viral entry into host cell via permeabilization of host organelle membrane" RELATED [GOC:bf, GOC:jl] +synonym: "viral membrane-penetration protein" RELATED [UniProtKB-KW:KW-1173] +synonym: "viral penetration via host endosomal membrane disruption by virus" EXACT [UniProtKB-KW:KW-1173] +synonym: "viral penetration via perforation of host organellar membrane by virus" EXACT [UniProtKB-KW:KW-1173] +synonym: "viral penetration via permeabilization of host organellar membrane" EXACT [UniProtKB-KW:KW-1173, VZ:985] +xref: VZ:985 "Viral penetration via permeabilization of host organellar membrane" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0140267 ! viral entry via permeabilization of host membrane + +[Term] +id: GO:0039666 +name: virion attachment to host cell pilus +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side." [UniProtKB-KW:KW-1175, VZ:981] +synonym: "pilus-adsorption protein" EXACT [PMID:16298408] +synonym: "pilus-mediated viral adsorption onto host cell" RELATED [UniProtKB-KW:KW-1175, VZ:981] +synonym: "pilus-mediated viral attachment to host cell" RELATED [GOC:bf, GOC:jl] +synonym: "viral attachment to host cell pilus" RELATED [GOC:bf, GOC:jl] +xref: VZ:981 "Pilus-mediated viral adsorption onto host cell" +is_a: GO:0019062 ! virion attachment to host cell + +[Term] +id: GO:0039667 +name: viral entry into host cell via pilus retraction +namespace: biological_process +def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus." [GOC:bf, GOC:jl, VZ:981] +comment: This method of entry into the cell differs between viruses; filamentous bacteriophages have rod-shaped virions which attach to the tip of the pilus; after retraction of the pilus with the virion attached, the genome can enter the host cell through the pilus basal pore. For icosahedral viruses, retraction of the pilus brings the virus in contact with the cell membrane and the genome can enter the cell via membrane fusion or genome injection. In GO, viral entry begins after viral attachment; for pilus-attachment proteins see instead: viral attachment to host cell pilus ; GO:0039666. +is_a: GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0039668 +name: viral entry into host cell via pilus basal pore +namespace: biological_process +def: "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way." [GOC:bf, GOC:jl] +synonym: "filamentous viral entry into host cell via pilus retraction" NARROW [GOC:bf, GOC:jl, VZ:981] +is_a: GO:0039667 ! viral entry into host cell via pilus retraction + +[Term] +id: GO:0039669 +name: viral entry into host cell via pilus retraction and membrane fusion +namespace: biological_process +def: "The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane." [GOC:bf, GOC:jl, PMID:20427561, VZ:981] +comment: For annotation of viral pilus-binding proteins, see also 'viral attachment to host cell pilus ; GO:0039666'. +is_a: GO:0039667 ! viral entry into host cell via pilus retraction + +[Term] +id: GO:0039670 +name: viral capsid, turret +namespace: cellular_component +def: "A turret-like appendage formed at the vertices of an icosahedral capsid." [GOC:jh2, PMID:20592081] +is_a: GO:0098021 ! viral capsid, decoration +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0039671 +name: evasion by virus of host natural killer cell activity +namespace: biological_process +def: "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131] +synonym: "evasion by virus of host natural killer cell response" EXACT [] +synonym: "evasion by virus of host NK cell killing" EXACT [GOC:bf] +synonym: "modulation of host NK-cell activity by virus" RELATED [UniProtKB-KW:KW-1131] +synonym: "protection by virus against host NK cell cytotoxicity" EXACT [PMID:12782710] +synonym: "suppression by virus of host natural killer cell function" EXACT [PMID:15640804] +synonym: "viral immunoevasion of host NK cell" EXACT [GOC:bf] +is_a: GO:0030683 ! mitigation of host immune response by virus + +[Term] +id: GO:0039672 +name: suppression by virus of host natural killer cell activation +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host." [GOC:bf, GOC:jl] +synonym: "suppression by virus of host NK-cell activation" EXACT [GOC:bf, GOC:jl] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0039671 ! evasion by virus of host natural killer cell activity + +[Term] +id: GO:0039673 +name: evasion by virus of host dendritic cell activity +namespace: biological_process +def: "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118] +synonym: "evasion by virus of host dendritic cell response" EXACT [] +synonym: "impairing dendritic cell function by virus" EXACT [UniProtKB-KW:KW-1118] +synonym: "modulation of host dendritic cell activity by virus" BROAD [UniProtKB-KW:KW-1118] +is_a: GO:0030683 ! mitigation of host immune response by virus + +[Term] +id: GO:0039674 +name: exit of virus from host cell nucleus +namespace: biological_process +def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus." [VZ:2177] +xref: VZ:2177 "Nuclear exit of viral genome" +is_a: GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:0039675 +name: exit of virus from host cell nucleus through nuclear pore +namespace: biological_process +def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore." [PMID:12921991, VZ:1953] +synonym: "exit of virus from host cell nucleus through nuclear pore complex" EXACT [] +synonym: "nuclear pore exit of virus" EXACT [VZ:1953] +synonym: "viral enome export through nuclear pore" EXACT [VZ:1953] +xref: VZ:1953 "Genome export through nuclear pore" +is_a: GO:0039674 ! exit of virus from host cell nucleus + +[Term] +id: GO:0039677 +name: exit of virus from host cell nucleus via nuclear envelope disassembly +namespace: biological_process +def: "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus." [VZ:2176] +synonym: "exit of virus from host cell nucleus via nuclear envelope breakdown" EXACT [VZ:2176] +xref: VZ:2176 "Nuclear envelope breakdown" +is_a: GO:0039674 ! exit of virus from host cell nucleus + +[Term] +id: GO:0039678 +name: viral genome ejection through host cell envelope +namespace: biological_process +def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171] +comment: When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'. +synonym: "phage genome ejection" NARROW [PMID:23385786] +synonym: "viral genome injection through bacterial membranes" NARROW [UniProtKB-KW:KW-1171] +is_a: GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0039679 +name: viral occlusion body +namespace: cellular_component +def: "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host." [UniProtKB-KW:KW-0842, VZ:1949] +xref: VZ:1949 "Occlusion bodies" +is_a: GO:0140220 ! pathogen-containing vacuole + +[Term] +id: GO:0039680 +name: actin-dependent intracellular transport of virus towards nucleus +namespace: biological_process +def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments." [UniProtKB-KW:KW-1178, VZ:991] +synonym: "actin-dependent intracellular transport of viral material towards nucleus" EXACT [] +synonym: "actin-dependent inwards viral transport" EXACT [VZ:991] +xref: VZ:991 "Actin-dependent inwards viral transport" +is_a: GO:0075520 ! actin-dependent intracellular transport of virus +is_a: GO:0075606 ! transport of viral material towards nucleus + +[Term] +id: GO:0039682 +name: rolling circle viral DNA replication +namespace: biological_process +def: "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA." [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication] +is_a: GO:0039687 ! viral DNA strand displacement replication + +[Term] +id: GO:0039683 +name: rolling circle double-stranded viral DNA replication +namespace: biological_process +def: "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:2676] +synonym: "dsDNA rolling circle replication" EXACT [VZ:2676] +xref: VZ:2676 "dsDNA rolling circle replication" +is_a: GO:0039682 ! rolling circle viral DNA replication + +[Term] +id: GO:0039684 +name: rolling circle single-stranded viral DNA replication +namespace: biological_process +def: "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:1941] +synonym: "ssDNA rolling circle replication" EXACT [VZ:1941] +xref: VZ:1941 "ssDNA Rolling circle" +is_a: GO:0039682 ! rolling circle viral DNA replication + +[Term] +id: GO:0039685 +name: rolling hairpin viral DNA replication +namespace: biological_process +def: "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA." [GOC:bf, GOC:jl, VZ:2656] +synonym: "ssDNA rolling hairpin viral DNA replication" EXACT [VZ:2656] +xref: VZ:2656 "Rolling hairpin replication" +is_a: GO:0039693 ! viral DNA genome replication + +[Term] +id: GO:0039686 +name: bidirectional double-stranded viral DNA replication +namespace: biological_process +def: "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions." [GOC:bf, GOC:jl, VZ:1939] +synonym: "viral bidirectional dsDNA replication" EXACT [VZ:1939] +xref: VZ:1939 "dsDNA bidirectional replication" +is_a: GO:0039693 ! viral DNA genome replication + +[Term] +id: GO:0039687 +name: viral DNA strand displacement replication +namespace: biological_process +def: "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA)." [GOC:bf, GOC:jl, VZ:1940] +xref: VZ:1940 "DNA strand displacement replication" +is_a: GO:0039693 ! viral DNA genome replication + +[Term] +id: GO:0039688 +name: viral double stranded DNA replication via reverse transcription +namespace: biological_process +def: "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:bf, GOC:jl, VZ:1938] +synonym: "dsDNA replication via RNA intermediate" EXACT [GOC:bf, GOC:jl] +synonym: "RNA-dependent viral DNA replication" RELATED [GOC:bf, GOC:jl] +synonym: "viral RNA-dependent DNA replication" EXACT [GOC:bf, GOC:jl] +xref: VZ:1938 "dsDNA(RT) replication/transcription" +is_a: GO:0039693 ! viral DNA genome replication + +[Term] +id: GO:0039689 +name: negative stranded viral RNA replication +namespace: biological_process +def: "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA)." [GOC:bf, GOC:jl, VZ:1096] +synonym: "(-)ss viral RNA replication" EXACT [VZ:1096] +xref: VZ:1096 "Negative stranded RNA virus replication" +is_a: GO:0039694 ! viral RNA genome replication + +[Term] +id: GO:0039690 +name: positive stranded viral RNA replication +namespace: biological_process +def: "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA." [GOC:bf, GOC:jl, VZ:1116] +synonym: "ss(+) viral RNA replication" RELATED [VZ:1116] +xref: VZ:1116 "Positive stranded RNA virus replication" +is_a: GO:0039694 ! viral RNA genome replication + +[Term] +id: GO:0039691 +name: double stranded viral RNA replication +namespace: biological_process +def: "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA." [GOC:bf, GOC:jl, VZ:1936] +xref: VZ:1936 "Double-stranded RNA virus replication" +is_a: GO:0039694 ! viral RNA genome replication + +[Term] +id: GO:0039692 +name: single stranded viral RNA replication via double stranded DNA intermediate +namespace: biological_process +alt_id: GO:0045090 +def: "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II." [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937] +synonym: "retroviral genome replication" EXACT [] +synonym: "viral ssRNA replication via dsDNA intermediate" RELATED [GOC:bf] +xref: VZ:1937 "ssRNA(RT) replication/transcription" +is_a: GO:0039694 ! viral RNA genome replication + +[Term] +id: GO:0039693 +name: viral DNA genome replication +namespace: biological_process +alt_id: GO:0039681 +def: "The replication of a viral DNA genome." [GOC:bf, GOC:jl, VZ:915] +synonym: "DNA-dependent viral DNA replication" EXACT [GOC:bf, GOC:jl] +synonym: "viral DNA replication" EXACT [GOC:bf, GOC:jl] +synonym: "viral DNA-dependent DNA replication" EXACT [] +is_a: GO:0019079 ! viral genome replication + +[Term] +id: GO:0039694 +name: viral RNA genome replication +namespace: biological_process +def: "The replication of a viral RNA genome." [GOC:bf, GOC:jl] +is_a: GO:0019079 ! viral genome replication + +[Term] +id: GO:0039695 +name: DNA-templated viral transcription +namespace: biological_process +def: "A transcription process that uses a viral DNA as a template." [GOC:bf, GOC:jl] +xref: VZ:1942 "dsDNA templated transcription" +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0039696 +name: RNA-templated viral transcription +namespace: biological_process +def: "A transcription process that uses viral RNA as a template." [GOC:bf, GOC:jl] +is_a: GO:0019083 ! viral transcription + +[Term] +id: GO:0039697 +name: negative stranded viral RNA transcription +namespace: biological_process +def: "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template." [VZ:1096] +xref: VZ:1096 "Negative stranded RNA virus replication" +is_a: GO:0039696 ! RNA-templated viral transcription + +[Term] +id: GO:0039698 +name: polyadenylation of viral mRNA by polymerase stuttering +namespace: biological_process +def: "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." [VZ:1916] +synonym: "polyA stuttering" EXACT [VZ:1916] +xref: VZ:1916 "Negative-stranded RNA virus Polymerase stuttering" +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0039699 +name: viral mRNA cap methylation +namespace: biological_process +def: "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a viral mRNA. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs." [UniProtKB-KW:KW-1196] +synonym: "IFIT mRNA restriction evasion by virus" EXACT [UniProtKB-KW:KW-1196] +is_a: GO:0039503 ! suppression by virus of host innate immune response + +[Term] +id: GO:0039700 +name: fusion of viral membrane with host outer nuclear membrane +namespace: biological_process +def: "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit." [PMID:23057731, UniProtKB-KW:KW-1181] +synonym: "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress" EXACT [GOC:bf] +synonym: "viral primary envelope fusion with host outer nuclear membrane" EXACT [UniProtKB-KW:KW-1181] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress + +[Term] +id: GO:0039701 +name: microtubule-dependent intracellular transport of viral material towards cell periphery +namespace: biological_process +def: "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane." [UniProtKB-KW:KW-1189, VZ:1816] +xref: VZ:1816 "Microtubular outwards viral transport" +is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material + +[Term] +id: GO:0039702 +name: viral budding via host ESCRT complex +namespace: biological_process +def: "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process." [UniProtKB-KW:KW-1187, VZ:1536] +synonym: "host-assisted viral budding" BROAD [VZ:1536] +synonym: "viral budding through the ESCRT machinery" RELATED [VZ:1536] +xref: VZ:1536 "Viral budding via the host ESCRT complexes" +is_a: GO:0046755 ! viral budding + +[Term] +id: GO:0039703 +name: RNA replication +namespace: biological_process +def: "The cellular metabolic process in which a cell duplicates one or more molecules of RNA." [GOC:bf, GOC:jl] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0039704 +name: viral translational shunt +namespace: biological_process +def: "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site." [PMID:15827182, PMID:18195037, VZ:608] +comment: This term is intended to annotate gene products involved in the process of viral translational shunt, not viral proteins produced by this translation process. +synonym: "ribosomal shunt initiation pathway" EXACT [PMID:18195037] +xref: VZ:608 "Ribosomal shunt" +is_a: GO:0019081 ! viral translation + +[Term] +id: GO:0039705 +name: viral translational readthrough +namespace: biological_process +def: "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859] +comment: This term is intended to annotate gene products involved in the process of viral translational readthrough, not viral proteins produced by this translation process. +synonym: "viral RNA suppression of termination" RELATED [VZ:859] +synonym: "viral stop codon readthrough" EXACT [VZ:859] +xref: VZ:859 "RNA suppression of termination" +is_a: GO:0006451 ! translational readthrough +relationship: part_of GO:0019081 ! viral translation + +[Term] +id: GO:0039706 +name: co-receptor binding +namespace: molecular_function +def: "Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0039707 +name: pore formation by virus in membrane of host cell +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism." [GOC:bf, GOC:jl, PMID:12972148, UniProtKB-KW:KW-1182] +synonym: "pore formation in membrane of host cell by virus" EXACT [GOC:bf] +synonym: "viroporin" RELATED [PMID:12972148, UniProtKB-KW:KW-1182] +is_a: GO:0016032 ! viral process +is_a: GO:0044658 ! pore formation in membrane of host by symbiont + +[Term] +id: GO:0039708 +name: nuclear capsid assembly +namespace: biological_process +def: "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly." [VZ:1516] +xref: VZ:1516 "Nuclear capsid assembly" +is_a: GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0039709 +name: cytoplasmic capsid assembly +namespace: biological_process +def: "The assembly of a virus capsid that occurs in the cytoplasm." [VZ:1950] +xref: VZ:1950 "Cytoplasmic capsid assembly/packaging" +is_a: GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0039710 +name: cytoplasmic icosahedral capsid assembly +namespace: biological_process +def: "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome." [VZ:1950] +is_a: GO:0039709 ! cytoplasmic capsid assembly + +[Term] +id: GO:0039711 +name: cytoplasmic helical capsid assembly +namespace: biological_process +def: "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome." [VZ:1950] +is_a: GO:0039709 ! cytoplasmic capsid assembly + +[Term] +id: GO:0039712 +name: obsolete induction by virus of host catalytic activity +namespace: biological_process +def: "OBSOLETE. Any viral process that activates or increases the frequency, rate or extent of host catalytic activity." [GOC:bf, GOC:jl] +comment: This term was obsoleted because it represents a molecular function. +synonym: "induction by virus of host enzyme activity" EXACT [GOC:bf, GOC:jl] +is_obsolete: true + +[Term] +id: GO:0039713 +name: viral factory +namespace: cellular_component +def: "An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951] +synonym: "virus factory" EXACT [PMID:22440839] +xref: VZ:1951 "Viral factories" +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0039714 +name: cytoplasmic viral factory +namespace: cellular_component +def: "A viral factory located in the cytoplasm of a host cell." [VZ:1951] +is_a: GO:0033655 ! host cell cytoplasm part +is_a: GO:0039713 ! viral factory + +[Term] +id: GO:0039715 +name: nuclear viral factory +namespace: cellular_component +def: "A viral factory located in the nucleus of a host cell." [VZ:1951] +is_a: GO:0039713 ! viral factory +relationship: part_of GO:0042025 ! host cell nucleus + +[Term] +id: GO:0039716 +name: viroplasm viral factory +namespace: cellular_component +def: "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae." [VZ:1951, Wikipedia:Viroplasm] +xref: Wikipedia:Viroplasm +is_a: GO:0039714 ! cytoplasmic viral factory + +[Term] +id: GO:0039717 +name: spherule viral factory +namespace: cellular_component +def: "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus." [VZ:1951] +xref: Wikipedia:Viroplasm +is_a: GO:0039714 ! cytoplasmic viral factory + +[Term] +id: GO:0039718 +name: double membrane vesicle viral factory +namespace: cellular_component +def: "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae." [PMID:22440839, VZ:1951] +synonym: "DMV viral factory" EXACT [VZ:1951] +is_a: GO:0039714 ! cytoplasmic viral factory + +[Term] +id: GO:0039719 +name: tube viral factory +namespace: cellular_component +def: "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories." [VZ:1951] +is_a: GO:0039714 ! cytoplasmic viral factory + +[Term] +id: GO:0039720 +name: virogenic stroma +namespace: cellular_component +def: "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled." [PMID:13358757, PMID:1433508, VZ:1951] +synonym: "VS" EXACT [VZ:1951] +is_a: GO:0039715 ! nuclear viral factory + +[Term] +id: GO:0039721 +name: peristromal region viral factory +namespace: cellular_component +def: "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses." [PMID:18434402, VZ:1951] +synonym: "PR" RELATED [PMID:18434402, VZ:1951] +is_a: GO:0039715 ! nuclear viral factory + +[Term] +id: GO:0039722 +name: suppression by virus of host toll-like receptor signaling pathway +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism." [UniProtKB-KW:KW-1225] +synonym: "inhibition of host TLR pathway by virus" EXACT [UniProtKB-KW:KW-1125] +synonym: "suppression by virus of host TLR signaling pathway" EXACT [] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:0039503 ! suppression by virus of host innate immune response + +[Term] +id: GO:0039723 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1." [PMID:22171259, PMID:34084167] +synonym: "inhibition of host TBK1 by virus" RELATED [] +synonym: "suppression by virus of host TBK1 activity" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0039724 +name: suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity +namespace: biological_process +def: "Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PMID:19153231, PMID:22532683, PMID:24173023] +synonym: "inhibition of host IKBKE by virus" RELATED [] +synonym: "suppression by virus of host IKBKE activity" RELATED [] +is_a: GO:0039537 ! suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + +[Term] +id: GO:0040001 +name: establishment of mitotic spindle localization +namespace: biological_process +alt_id: GO:0018986 +alt_id: GO:0030605 +alt_id: GO:0030606 +alt_id: GO:0030608 +alt_id: GO:0030610 +def: "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai] +synonym: "establishment of mitotic spindle localisation" EXACT [GOC:mah] +synonym: "mitotic spindle positioning" EXACT [] +synonym: "mitotic spindle positioning and orientation" NARROW [] +synonym: "mitotic spindle positioning or orientation" EXACT [] +synonym: "spindle positioning during mitosis" RELATED [] +synonym: "spindle positioning involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051293 ! establishment of spindle localization +is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis + +[Term] +id: GO:0040002 +name: collagen and cuticulin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] +synonym: "collagen and cuticulin-based cuticle anabolism" EXACT [] +synonym: "collagen and cuticulin-based cuticle biosynthetic process" EXACT [] +synonym: "collagen and cuticulin-based cuticle formation" EXACT [] +synonym: "collagen and cuticulin-based cuticle synthesis" EXACT [] +is_a: GO:0042335 ! cuticle development + +[Term] +id: GO:0040003 +name: chitin-based cuticle development +namespace: biological_process +def: "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] +synonym: "chitin-based cuticle anabolism" EXACT [] +synonym: "chitin-based cuticle biosynthetic process" EXACT [] +synonym: "chitin-based cuticle formation" EXACT [] +synonym: "chitin-based cuticle synthesis" EXACT [] +is_a: GO:0042335 ! cuticle development + +[Term] +id: GO:0040004 +name: collagen and cuticulin-based cuticle attachment to epithelium +namespace: biological_process +def: "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] +synonym: "cuticular attachment to epithelium" BROAD [] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0040005 +name: chitin-based cuticle attachment to epithelium +namespace: biological_process +def: "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] +synonym: "cuticular attachment to epithelium" BROAD [] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0040006 +name: obsolete protein-based cuticle attachment to epithelium +namespace: biological_process +def: "OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu] +comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. +synonym: "cuticular attachment to epithelium" BROAD [] +synonym: "protein-based cuticle attachment to epithelium" EXACT [] +is_obsolete: true +consider: GO:0040004 +consider: GO:0040005 + +[Term] +id: GO:0040007 +name: growth +namespace: biological_process +alt_id: GO:0048590 +def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] +comment: See also the biological process term 'cell growth ; GO:0016049'. +subset: gocheck_do_not_annotate +subset: goslim_chembl +subset: goslim_pir +subset: goslim_plant +synonym: "growth pattern" RELATED [] +synonym: "non-developmental growth" RELATED [GOC:mah] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0040008 +name: regulation of growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0040007 ! growth + +[Term] +id: GO:0040009 +name: regulation of growth rate +namespace: biological_process +def: "Any process that modulates the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +is_a: GO:0040008 ! regulation of growth + +[Term] +id: GO:0040010 +name: positive regulation of growth rate +namespace: biological_process +def: "Any process that increases the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +synonym: "activation of growth rate" NARROW [] +synonym: "stimulation of growth rate" NARROW [] +synonym: "up regulation of growth rate" EXACT [] +synonym: "up-regulation of growth rate" EXACT [] +synonym: "upregulation of growth rate" EXACT [] +is_a: GO:0040009 ! regulation of growth rate +is_a: GO:0045927 ! positive regulation of growth + +[Term] +id: GO:0040011 +name: locomotion +namespace: biological_process +def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] +subset: goslim_chembl +subset: goslim_pir +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0040012 +name: regulation of locomotion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040013 +name: negative regulation of locomotion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] +synonym: "down regulation of locomotion" EXACT [] +synonym: "down-regulation of locomotion" EXACT [] +synonym: "downregulation of locomotion" EXACT [] +synonym: "inhibition of locomotion" NARROW [] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040014 +name: regulation of multicellular organism growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb] +synonym: "regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040015 +name: negative regulation of multicellular organism growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb] +synonym: "negative regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040014 ! regulation of multicellular organism growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040016 +name: embryonic cleavage +namespace: biological_process +def: "The first few specialized divisions of an activated animal egg." [GOC:clt, ISBN:0070524300] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0040017 +name: positive regulation of locomotion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators] +synonym: "activation of locomotion" NARROW [] +synonym: "stimulation of locomotion" NARROW [] +synonym: "up regulation of locomotion" EXACT [] +synonym: "up-regulation of locomotion" EXACT [] +synonym: "upregulation of locomotion" EXACT [] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0040011 ! locomotion + +[Term] +id: GO:0040018 +name: positive regulation of multicellular organism growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "positive regulation of body growth" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of body size" EXACT [GOC:dph, GOC:tb] +is_a: GO:0040014 ! regulation of multicellular organism growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0035264 ! multicellular organism growth + +[Term] +id: GO:0040019 +name: positive regulation of embryonic development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators] +synonym: "activation of embryonic development" NARROW [] +synonym: "stimulation of embryonic development" NARROW [] +synonym: "up regulation of embryonic development" EXACT [] +synonym: "up-regulation of embryonic development" EXACT [] +synonym: "upregulation of embryonic development" EXACT [] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009790 ! embryo development + +[Term] +id: GO:0040020 +name: regulation of meiotic nuclear division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma] +synonym: "regulation of meiosis" BROAD [GOC:vw] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051445 ! regulation of meiotic cell cycle +is_a: GO:0051783 ! regulation of nuclear division +relationship: regulates GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0040021 +name: hermaphrodite germ-line sex determination +namespace: biological_process +alt_id: GO:0042005 +def: "The determination of sex and sexual phenotype in the germ line of a hermaphrodite." [GOC:ems] +is_a: GO:0018992 ! germ-line sex determination + +[Term] +id: GO:0040022 +name: feminization of hermaphroditic germ-line +namespace: biological_process +def: "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems] +is_a: GO:0040021 ! hermaphrodite germ-line sex determination + +[Term] +id: GO:0040024 +name: dauer larval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X] +is_a: GO:0002119 ! nematode larval development + +[Term] +id: GO:0040025 +name: vulval development +namespace: biological_process +def: "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X] +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0002119 ! nematode larval development + +[Term] +id: GO:0040026 +name: positive regulation of vulval development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] +synonym: "activation of vulval development" RELATED [] +synonym: "stimulation of vulval development" RELATED [] +synonym: "up regulation of vulval development" RELATED [] +synonym: "up-regulation of vulval development" RELATED [] +synonym: "upregulation of vulval development" RELATED [] +is_a: GO:0040028 ! regulation of vulval development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040027 +name: negative regulation of vulval development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv] +synonym: "down regulation of vulval development" EXACT [] +synonym: "down-regulation of vulval development" EXACT [] +synonym: "downregulation of vulval development" EXACT [] +synonym: "inhibition of vulval development" NARROW [] +is_a: GO:0040028 ! regulation of vulval development +is_a: GO:0061064 ! negative regulation of nematode larval development +relationship: negatively_regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040028 +name: regulation of vulval development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0040025 ! vulval development + +[Term] +id: GO:0040029 +name: regulation of gene expression, epigenetic +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal." [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474] +subset: goslim_plant +is_a: GO:0010468 ! regulation of gene expression +relationship: part_of GO:0006325 ! chromatin organization + +[Term] +id: GO:0040030 +name: obsolete regulation of molecular function, epigenetic +namespace: biological_process +def: "OBSOLETE. Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551] +comment: This term was obsoleted because it is not an active process. +synonym: "regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0040031 +name: snRNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl] +is_a: GO:0009451 ! RNA modification +is_a: GO:0016073 ! snRNA metabolic process + +[Term] +id: GO:0040032 +name: post-embryonic body morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888] +comment: Note that this term was 'body morphogenesis (sensu Nematoda)'. +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0010171 ! body morphogenesis + +[Term] +id: GO:0040033 +name: RNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb] +synonym: "down regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "down-regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "downregulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "inhibition of mRNA translation, ncRNA-mediated" NARROW [] +synonym: "negative regulation of translation, ncRNA-mediated" EXACT [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0035194 ! post-transcriptional gene silencing by RNA + +[Term] +id: GO:0040034 +name: regulation of development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909] +synonym: "developmental timing" RELATED [] +synonym: "heterochronic regulation of development" EXACT [] +synonym: "temporal regulation of development" EXACT [] +is_a: GO:0050793 ! regulation of developmental process + +[Term] +id: GO:0040035 +name: hermaphrodite genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888] +is_a: GO:0008406 ! gonad development +is_a: GO:0048806 ! genitalia development + +[Term] +id: GO:0040036 +name: regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "regulation of FGF receptor signaling pathway" EXACT [] +synonym: "regulation of FGF receptor signalling pathway" EXACT [] +synonym: "regulation of FGFR signaling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0040037 +name: negative regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of FGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of FGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of FGFR signaling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +relationship: negatively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0040038 +name: polar body extrusion after meiotic divisions +namespace: biological_process +def: "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0033206 ! meiotic cytokinesis +relationship: part_of GO:0007143 ! female meiotic nuclear division + +[Term] +id: GO:0040039 +name: inductive cell migration +namespace: biological_process +def: "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0040040 +name: thermosensory behavior +namespace: biological_process +def: "Behavior that is dependent upon the sensation of temperature." [GOC:ems] +synonym: "behavioral response to temperature stimulus" EXACT [] +synonym: "behavioural response to temperature stimulus" EXACT [] +synonym: "thermosensory behaviour" EXACT [] +is_a: GO:0007610 ! behavior +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0042000 +name: translocation of peptides or proteins into host +namespace: biological_process +alt_id: GO:0051808 +def: "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "translocation of peptides or proteins into other organism during symbiotic interaction" BROAD [GOC:tb] +synonym: "translocation of peptides or proteins into other organism involved in symbiotic interaction" BROAD [] +synonym: "transport of peptides or proteins into host" EXACT [] +synonym: "transport of peptides or proteins into other organism during symbiotic interaction" BROAD [] +is_a: GO:0015031 ! protein transport +is_a: GO:0044417 ! translocation of molecules into host + +[Term] +id: GO:0042001 +name: hermaphrodite somatic sex determination +namespace: biological_process +alt_id: GO:0042002 +def: "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] +is_a: GO:0018993 ! somatic sex determination + +[Term] +id: GO:0042003 +name: masculinization of hermaphrodite soma +namespace: biological_process +def: "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] +is_a: GO:0042001 ! hermaphrodite somatic sex determination + +[Term] +id: GO:0042004 +name: feminization of hermaphrodite soma +namespace: biological_process +def: "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems] +is_a: GO:0042001 ! hermaphrodite somatic sex determination + +[Term] +id: GO:0042006 +name: masculinization of hermaphroditic germ-line +namespace: biological_process +def: "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems] +is_a: GO:0040021 ! hermaphrodite germ-line sex determination + +[Term] +id: GO:0042007 +name: interleukin-18 binding +namespace: molecular_function +def: "Binding to interleukin-18." [GOC:jl] +synonym: "IL-18 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042008 +name: interleukin-18 receptor activity +namespace: molecular_function +def: "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-18 receptor activity" EXACT [GOC:mah] +synonym: "IL-18R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042009 +name: interleukin-15 binding +namespace: molecular_function +def: "Binding to interleukin-15." [GOC:jl] +synonym: "IL-15 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042010 +name: interleukin-15 receptor activity +namespace: molecular_function +def: "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-15 receptor activity" EXACT [GOC:mah] +synonym: "IL-15R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042011 +name: interleukin-16 binding +namespace: molecular_function +def: "Binding to interleukin-16." [GOC:jl] +synonym: "IL-16 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042012 +name: interleukin-16 receptor activity +namespace: molecular_function +def: "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-16 receptor activity" EXACT [GOC:mah] +synonym: "IL-16R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042013 +name: interleukin-19 binding +namespace: molecular_function +def: "Binding to interleukin-19." [GOC:jl] +synonym: "IL-19 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042014 +name: interleukin-19 receptor activity +namespace: molecular_function +def: "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-19 receptor activity" EXACT [GOC:mah] +synonym: "IL-19R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042015 +name: interleukin-20 binding +namespace: molecular_function +def: "Binding to interleukin-20." [GOC:jl] +synonym: "IL-20 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042016 +name: interleukin-20 receptor activity +namespace: molecular_function +def: "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-20 receptor activity" EXACT [GOC:mah] +synonym: "IL-20R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042017 +name: interleukin-22 binding +namespace: molecular_function +def: "Binding to interleukin-22." [GOC:jl] +synonym: "IL-22 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042018 +name: interleukin-22 receptor activity +namespace: molecular_function +def: "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-22 receptor activity" EXACT [GOC:mah] +synonym: "IL-22R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042019 +name: interleukin-23 binding +namespace: molecular_function +def: "Binding to interleukin-23." [GOC:jl] +synonym: "IL-23 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042020 +name: interleukin-23 receptor activity +namespace: molecular_function +def: "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-23 receptor activity" EXACT [GOC:mah] +synonym: "IL-23R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0042021 +name: granulocyte macrophage colony-stimulating factor complex binding +namespace: molecular_function +def: "Binding to a granulocyte macrophage colony-stimulating factor complex." [GOC:ai] +synonym: "GM-CSF complex binding" EXACT [] +synonym: "GMC-SF complex binding" EXACT [] +synonym: "granulocyte macrophage colony stimulating factor complex binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0042022 +name: interleukin-12 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:ebc, GOC:mah, PMID:10971505] +synonym: "IL-12 receptor complex" EXACT [GOC:add] +synonym: "IL12RB1-IL12RB2 complex" NARROW [CORUM:2026] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0042023 +name: DNA endoreduplication +namespace: biological_process +def: "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw] +comment: Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states. +synonym: "DNA endoreplication" EXACT [] +synonym: "DNA re-duplication" EXACT [] +is_a: GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:0042025 +name: host cell nucleus +namespace: cellular_component +alt_id: GO:0033649 +def: "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle + +[Term] +id: GO:0042026 +name: protein refolding +namespace: biological_process +def: "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb] +synonym: "heat shock protein activity" RELATED [] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0042027 +name: obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8] +comment: This term was made obsolete because it is contains gene product specific characteristics. +synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" EXACT [] +is_obsolete: true +consider: GO:0003755 + +[Term] +id: GO:0042029 +name: obsolete fibrolase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [PMID:7725320] +comment: This term was made obsolete because it represents a gene product. +synonym: "Agkistrodon contortrix contortrix metalloproteinase activity" NARROW [] +synonym: "Agkistrodon contortrix contortrix venom metalloproteinase activity" NARROW [] +synonym: "fibrinolytic proteinase activity" RELATED [] +synonym: "fibrolase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004222 + +[Term] +id: GO:0042030 +name: ATPase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces an ATP hydrolysis activity." [GOC:jl] +synonym: "adenosinetriphosphatase inhibitor" EXACT [] +is_a: GO:0140678 ! molecular function inhibitor activity + +[Term] +id: GO:0042031 +name: obsolete angiotensin-converting enzyme inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl] +comment: This term was made obsolete because it represents a regulator of a non-existent molecular function term. +synonym: "ACE inhibitor" EXACT [] +synonym: "angiotensin-converting enzyme inhibitor activity" EXACT [] +synonym: "peptidyl dipeptidase A inhibitor" EXACT [] +is_obsolete: true +replaced_by: GO:0060422 + +[Term] +id: GO:0042034 +name: peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine +namespace: biological_process +def: "The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester." [RESID:AA0318] +synonym: "peptidyl-lysine esterification" EXACT [] +xref: RESID:AA0318 +is_a: GO:0006481 ! C-terminal protein methylation +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0042037 +name: peptidyl-histidine methylation, to form pros-methylhistidine +namespace: biological_process +alt_id: GO:0042260 +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073] +synonym: "peptidyl-histidine pros-methylation" EXACT [] +xref: RESID:AA0073 +is_a: GO:0018021 ! peptidyl-histidine methylation + +[Term] +id: GO:0042038 +name: peptidyl-histidine methylation, to form tele-methylhistidine +namespace: biological_process +alt_id: GO:0042261 +def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317] +synonym: "peptidyl-histidine tele-methylation" EXACT [] +xref: RESID:AA0317 +is_a: GO:0018021 ! peptidyl-histidine methylation + +[Term] +id: GO:0042039 +name: vanadium incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n)." [PMID:11053414] +synonym: "vanadium incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0042040 +name: metal incorporation into metallo-molybdopterin complex +namespace: biological_process +def: "The incorporation of a metal into a metallo-molybdopterin complex." [GOC:ai] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0042042 +name: tungsten incorporation into tungsten-molybdopterin complex +namespace: biological_process +def: "The incorporation of tungsten into a tungsten-molybdopterin complex." [GOC:ai] +is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex + +[Term] +id: GO:0042043 +name: neurexin family protein binding +namespace: molecular_function +alt_id: GO:0019963 +def: "Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512] +synonym: "neuroligin" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042044 +name: fluid transport +namespace: biological_process +def: "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_pir +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042045 +name: epithelial fluid transport +namespace: biological_process +def: "The directed movement of fluid across epithelia." [GOC:jl, PMID:11390830] +is_a: GO:0042044 ! fluid transport +is_a: GO:0070633 ! transepithelial transport + +[Term] +id: GO:0042046 +name: W-molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +synonym: "Moco metabolic process" BROAD [] +synonym: "Moco metabolism" BROAD [] +synonym: "W-molybdopterin cofactor metabolism" EXACT [] +is_a: GO:0043545 ! molybdopterin cofactor metabolic process + +[Term] +id: GO:0042047 +name: W-molybdopterin cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +synonym: "Moco biosynthesis" BROAD [] +synonym: "Moco biosynthetic process" BROAD [] +synonym: "W-molybdopterin cofactor anabolism" EXACT [] +synonym: "W-molybdopterin cofactor biosynthesis" EXACT [] +synonym: "W-molybdopterin cofactor formation" EXACT [] +synonym: "W-molybdopterin cofactor synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042048 +name: olfactory behavior +namespace: biological_process +def: "The behavior of an organism in response to an odor." [GOC:jid, GOC:pr] +synonym: "behavioral response to scent" EXACT [] +synonym: "behavioral response to smell" EXACT [] +synonym: "behavioural response to odour" EXACT [] +synonym: "behavioural response to scent" EXACT [] +synonym: "behavioural response to smell" EXACT [] +synonym: "olfactory behaviour" EXACT [] +is_a: GO:0007635 ! chemosensory behavior + +[Term] +id: GO:0042049 +name: cellular acyl-CoA homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb] +synonym: "cell acyl-CoA homeostasis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0055082 ! cellular chemical homeostasis + +[Term] +id: GO:0042051 +name: compound eye photoreceptor development +namespace: biological_process +def: "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf] +synonym: "adult eye photoreceptor development" NARROW [] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0042052 +name: rhabdomere development +namespace: biological_process +def: "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883] +synonym: "rhabdomere organization" EXACT [GOC:mah] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0042053 +name: regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "regulation of dopamine metabolism" EXACT [] +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0042054 +name: histone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [GOC:curators] +synonym: "histone methylase activity" EXACT [GOC:mah] +xref: EC:2.1.1.354 +is_a: GO:0008276 ! protein methyltransferase activity + +[Term] +id: GO:0042056 +name: chemoattractant activity +namespace: molecular_function +def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732] +subset: goslim_chembl +subset: goslim_pir +synonym: "attractant" BROAD [] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0042057 +name: obsolete transforming growth factor beta receptor anchoring activity +namespace: molecular_function +def: "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai] +comment: This term was made obsolete because it represents a combination of process and function information. +synonym: "TGF-beta receptor anchoring activity" EXACT [] +synonym: "TGFbeta receptor anchoring activity" EXACT [] +synonym: "transforming growth factor beta receptor anchor activity" EXACT [] +synonym: "transforming growth factor beta receptor anchoring activity" EXACT [] +is_obsolete: true +consider: GO:0005160 +consider: GO:0008104 + +[Term] +id: GO:0042058 +name: regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "regulation of EGF receptor signaling pathway" EXACT [] +synonym: "regulation of EGF receptor signalling pathway" EXACT [] +synonym: "regulation of EGFR signaling pathway" EXACT [] +is_a: GO:1901184 ! regulation of ERBB signaling pathway +relationship: regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0042059 +name: negative regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "down regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of EGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of EGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of EGFR signaling pathway" EXACT [] +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +is_a: GO:1901185 ! negative regulation of ERBB signaling pathway +relationship: negatively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0042060 +name: wound healing +namespace: biological_process +def: "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788] +subset: goslim_generic +xref: Wikipedia:Wound_healing +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0042062 +name: long-term strengthening of neuromuscular junction +namespace: biological_process +def: "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021] +is_a: GO:0050806 ! positive regulation of synaptic transmission +relationship: part_of GO:0008582 ! regulation of synaptic assembly at neuromuscular junction + +[Term] +id: GO:0042063 +name: gliogenesis +namespace: biological_process +def: "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid] +synonym: "glial cell generation" EXACT systematic_synonym [] +is_a: GO:0022008 ! neurogenesis + +[Term] +id: GO:0042064 +name: obsolete cell adhesion receptor regulator activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cell adhesion receptor regulator activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0030155 + +[Term] +id: GO:0042065 +name: glial cell growth +namespace: biological_process +def: "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0042066 +name: perineurial glial growth +namespace: biological_process +def: "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560] +is_a: GO:0042065 ! glial cell growth + +[Term] +id: GO:0042067 +name: establishment of ommatidial planar polarity +namespace: biological_process +def: "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883] +synonym: "establishment of ommatidial polarity" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0042068 +name: regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +synonym: "regulation of pteridine metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0042069 +name: regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators] +synonym: "regulation of catecholamine metabolism" EXACT [] +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042070 +name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0048127 +def: "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] +synonym: "maintenance of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] +synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] +synonym: "maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "maintenance of oocyte nucleus location involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] +synonym: "maintenance of oocyte nucleus position during oocyte axis determination" BROAD [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus localization" BROAD [] +synonym: "oocyte axis determination, maintenance of oocyte nucleus position" BROAD [] +synonym: "oocyte axis determination, oocyte nucleus anchoring" BROAD [] +synonym: "oocyte nucleus anchoring during oocyte axis determination" BROAD [] +is_a: GO:0051658 ! maintenance of nucleus location +is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification + +[Term] +id: GO:0042071 +name: leucokinin receptor activity +namespace: molecular_function +def: "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0042072 +name: obsolete cell adhesion receptor inhibitor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "cell adhesion receptor inhibitor activity" EXACT [] +is_obsolete: true +consider: GO:0005102 +consider: GO:0007162 + +[Term] +id: GO:0042073 +name: intraciliary transport +namespace: biological_process +alt_id: GO:0035734 +def: "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374, Reactome:R-HSA-5620924.2] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "IFT" RELATED [] +synonym: "intraflagellar transport" EXACT [] +synonym: "intraflagellar transport involved in cilium organization" EXACT [] +synonym: "intraflagellar transport involved in microtubule-based flagellum organisation" EXACT [] +xref: Wikipedia:Intraflagellar_transport +is_a: GO:0010970 ! transport along microtubule +is_a: GO:0031503 ! protein-containing complex localization +relationship: part_of GO:0044782 ! cilium organization + +[Term] +id: GO:0042074 +name: cell migration involved in gastrulation +namespace: biological_process +def: "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437] +is_a: GO:0001667 ! ameboidal-type cell migration +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0042075 +name: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide +namespace: biological_process +def: "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] +synonym: "nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] +xref: RESID:AA0310 +is_a: GO:0016226 ! iron-sulfur cluster assembly +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018202 ! peptidyl-histidine modification +is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster + +[Term] +id: GO:0042076 +name: protein phosphate-linked glycosylation +namespace: biological_process +def: "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424] +synonym: "phosphoglycosylation" EXACT [] +synonym: "protein amino acid phosphate-linked glycosylation" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0042077 +name: protein phosphate-linked glycosylation via serine +namespace: biological_process +def: "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah] +synonym: "protein amino acid phosphate-linked glycosylation via serine" EXACT [GOC:bf] +is_a: GO:0042076 ! protein phosphate-linked glycosylation + +[Term] +id: GO:0042078 +name: germ-line stem cell division +namespace: biological_process +alt_id: GO:0048131 +def: "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698] +synonym: "germ-line stem cell renewal" EXACT [] +is_a: GO:0017145 ! stem cell division +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0042079 +name: obsolete GPI/GSI anchor metabolic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +synonym: "GPI/GSI anchor metabolic process" EXACT [] +is_obsolete: true +consider: GO:0006505 +consider: GO:0042081 + +[Term] +id: GO:0042080 +name: obsolete GPI/GSI anchor biosynthetic process +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:ai] +comment: This term was made obsolete because it is a composite term that represents two individual processes. +synonym: "GPI/GSI anchor anabolism" EXACT [] +synonym: "GPI/GSI anchor biosynthesis" EXACT [] +synonym: "GPI/GSI anchor biosynthetic process" EXACT [] +synonym: "GPI/GSI anchor formation" EXACT [] +synonym: "GPI/GSI anchor synthesis" EXACT [] +is_obsolete: true +consider: GO:0006506 +consider: GO:0042082 + +[Term] +id: GO:0042081 +name: GSI anchor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators] +synonym: "GPI/GSI anchor metabolic process" BROAD [] +synonym: "GPI/GSI anchor metabolism" BROAD [] +synonym: "GSI anchor metabolism" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0042082 +name: GSI anchor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg] +synonym: "GPI/GSI anchor biosynthesis" BROAD [] +synonym: "GPI/GSI anchor biosynthetic process" BROAD [] +synonym: "GSI anchor anabolism" EXACT [] +synonym: "GSI anchor biosynthesis" EXACT [] +synonym: "GSI anchor formation" EXACT [] +synonym: "GSI anchor synthesis" EXACT [] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0042081 ! GSI anchor metabolic process + +[Term] +id: GO:0042083 +name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042084 +name: 5-methyltetrahydrofolate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042085 +name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042086 +name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0042088 +name: T-helper 1 type immune response +namespace: biological_process +def: "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149] +synonym: "Th1 immune response" EXACT [] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0042092 +name: type 2 immune response +namespace: biological_process +def: "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518] +synonym: "T-helper 2 type immune response" NARROW [GOC:add] +synonym: "Th2 immune response" NARROW [GOC:add] +is_a: GO:0006955 ! immune response + +[Term] +id: GO:0042093 +name: T-helper cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc] +synonym: "helper T cell differentiation" EXACT [CL:0000912] +synonym: "T-helper cell development" RELATED [GOC:add] +is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response + +[Term] +id: GO:0042096 +name: obsolete alpha-beta T cell receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +synonym: "alpha-beta T cell receptor activity" EXACT [] +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0042098 +name: T cell proliferation +namespace: biological_process +alt_id: GO:0042111 +def: "The expansion of a T cell population by cell division. Follows T cell activation." [GOC:jl] +synonym: "T lymphocyte proliferation" EXACT [] +synonym: "T-cell proliferation" EXACT [] +synonym: "T-lymphocyte proliferation" EXACT [] +is_a: GO:0042110 ! T cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0042099 +name: obsolete gamma-delta T cell receptor activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:jl] +comment: This term was made obsolete because it describes a receptor type, and not an activity. +synonym: "gamma-delta T cell receptor activity" EXACT [] +is_obsolete: true +consider: GO:0032394 +consider: GO:0032395 +consider: GO:0042605 + +[Term] +id: GO:0042100 +name: B cell proliferation +namespace: biological_process +alt_id: GO:0042114 +def: "The expansion of a B cell population by cell division. Follows B cell activation." [GOC:jl] +synonym: "B lymphocyte proliferation" EXACT [] +synonym: "B-cell proliferation" EXACT [] +synonym: "B-lymphocyte proliferation" EXACT [] +is_a: GO:0042113 ! B cell activation +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0042101 +name: T cell receptor complex +namespace: cellular_component +def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149] +synonym: "T lymphocyte receptor complex" EXACT [] +synonym: "T-cell receptor complex" EXACT [] +synonym: "T-lymphocyte receptor complex" EXACT [] +synonym: "TCR" RELATED [] +synonym: "TCR complex" EXACT [GOC:bf] +xref: Wikipedia:T_cell_receptor +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0042102 +name: positive regulation of T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of T cell proliferation." [GOC:ai] +synonym: "activation of T cell proliferation" NARROW [] +synonym: "positive regulation of T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of T cell proliferation" NARROW [] +synonym: "up regulation of T cell proliferation" EXACT [] +synonym: "up-regulation of T cell proliferation" EXACT [] +synonym: "upregulation of T cell proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0050671 ! positive regulation of lymphocyte proliferation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042103 +name: positive regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl] +synonym: "activation of T cell homeostatic proliferation" NARROW [] +synonym: "positive regulation of resting T cell proliferation" EXACT [] +synonym: "positive regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "positive regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "positive regulation of T-lymphocyte homeostatic proliferation" EXACT [] +synonym: "stimulation of T cell homeostatic proliferation" NARROW [] +synonym: "up regulation of T cell homeostatic proliferation" EXACT [] +synonym: "up-regulation of T cell homeostatic proliferation" EXACT [] +synonym: "upregulation of T cell homeostatic proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046013 ! regulation of T cell homeostatic proliferation +relationship: positively_regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0042104 +name: positive regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl] +synonym: "activation of activated T cell proliferation" NARROW [] +synonym: "positive regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of activated T-cell proliferation" EXACT [] +synonym: "positive regulation of activated T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of activated T cell proliferation" NARROW [] +synonym: "up regulation of activated T cell proliferation" EXACT [] +synonym: "up-regulation of activated T cell proliferation" EXACT [] +synonym: "upregulation of activated T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046006 ! regulation of activated T cell proliferation +relationship: positively_regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0042105 +name: alpha-beta T cell receptor complex +namespace: cellular_component +def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149] +synonym: "alpha-beta T lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta T-cell receptor complex" EXACT [] +synonym: "alpha-beta T-lymphocyte receptor complex" EXACT [] +synonym: "alpha-beta TCR complex" EXACT [] +is_a: GO:0042101 ! T cell receptor complex + +[Term] +id: GO:0042106 +name: gamma-delta T cell receptor complex +namespace: cellular_component +def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149] +synonym: "gamma-delta T lymphocyte receptor complex" EXACT [] +synonym: "gamma-delta T-cell receptor complex" EXACT [] +synonym: "gamma-delta T-lymphocyte receptor complex" EXACT [] +synonym: "gamma-delta TCR complex" EXACT [] +is_a: GO:0042101 ! T cell receptor complex + +[Term] +id: GO:0042110 +name: T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] +synonym: "T lymphocyte activation" EXACT [] +synonym: "T-cell activation" EXACT [] +synonym: "T-lymphocyte activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0042113 +name: B cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735149] +synonym: "B lymphocyte activation" EXACT [] +synonym: "B-cell activation" EXACT [] +synonym: "B-lymphocyte activation" EXACT [] +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0042116 +name: macrophage activation +namespace: biological_process +def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301] +synonym: "macrophage polarization" EXACT [] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0042117 +name: monocyte activation +namespace: biological_process +def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0042118 +name: endothelial cell activation +namespace: biological_process +def: "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0042119 +name: neutrophil activation +namespace: biological_process +def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] +is_a: GO:0036230 ! granulocyte activation + +[Term] +id: GO:0042120 +name: alginic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] +synonym: "alginate metabolic process" EXACT [] +synonym: "alginate metabolism" EXACT [] +synonym: "alginic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0042121 +name: alginic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] +synonym: "alginate biosynthesis" EXACT [] +synonym: "alginate biosynthetic process" EXACT [] +synonym: "alginic acid anabolism" EXACT [] +synonym: "alginic acid biosynthesis" EXACT [] +synonym: "alginic acid formation" EXACT [] +synonym: "alginic acid synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0042120 ! alginic acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0042122 +name: alginic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732] +synonym: "alginate catabolic process" EXACT [] +synonym: "alginate catabolism" EXACT [] +synonym: "alginic acid breakdown" EXACT [] +synonym: "alginic acid catabolism" EXACT [] +synonym: "alginic acid degradation" EXACT [] +is_a: GO:0042120 ! alginic acid metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0042123 +name: glucanosyltransferase activity +namespace: molecular_function +def: "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl] +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0042124 +name: 1,3-beta-glucanosyltransferase activity +namespace: molecular_function +def: "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation." [GOC:jl, PMID:10809732] +is_a: GO:0042123 ! glucanosyltransferase activity + +[Term] +id: GO:0042125 +name: protein galactosylation +namespace: biological_process +def: "The addition of a galactose molecule to a protein amino acid." [GOC:jl, GOC:pr] +synonym: "protein amino acid galactosylation" EXACT [GOC:bf] +is_a: GO:0006486 ! protein glycosylation + +[Term] +id: GO:0042126 +name: nitrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] +synonym: "nitrate metabolism" EXACT [] +is_a: GO:0043436 ! oxoacid metabolic process +is_a: GO:2001057 ! reactive nitrogen species metabolic process + +[Term] +id: GO:0042127 +name: regulation of cell population proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation." [GOC:jl] +synonym: "regulation of cell proliferation" RELATED [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0008283 ! cell population proliferation + +[Term] +id: GO:0042128 +name: nitrate assimilation +namespace: biological_process +def: "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899] +synonym: "assimilatory nitrate reduction" EXACT [] +xref: MetaCyc:PWY-381 +is_a: GO:0042126 ! nitrate metabolic process +is_a: GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:0042129 +name: regulation of T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell proliferation." [GOC:jl] +synonym: "regulation of T lymphocyte proliferation" EXACT [] +synonym: "regulation of T-cell proliferation" EXACT [] +synonym: "regulation of T-lymphocyte proliferation" EXACT [] +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042130 +name: negative regulation of T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of T cell proliferation." [GOC:jl] +synonym: "down regulation of T cell proliferation" EXACT [] +synonym: "down-regulation of T cell proliferation" EXACT [] +synonym: "downregulation of T cell proliferation" EXACT [] +synonym: "inhibition of T cell proliferation" NARROW [] +synonym: "negative regulation of T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of T-cell proliferation" EXACT [] +synonym: "negative regulation of T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0050672 ! negative regulation of lymphocyte proliferation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0042098 ! T cell proliferation + +[Term] +id: GO:0042131 +name: thiamine phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate." [PMID:197075] +synonym: "thiamin monophosphate phosphatase" EXACT [] +synonym: "thiamin phosphate phosphatase activity" EXACT [] +synonym: "ThMPase" EXACT [] +is_a: GO:0003993 ! acid phosphatase activity + +[Term] +id: GO:0042132 +name: fructose 1,6-bisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11] +synonym: "D-fructose 1,6-diphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "D-fructose-1,6-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.11] +synonym: "D-fructose-1,6-bisphosphate phosphatase activity" RELATED [EC:3.1.3.11] +synonym: "FBPase activity" RELATED [EC:3.1.3.11] +synonym: "fructose 1,6-bisphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose 1,6-bisphosphate phosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose 1,6-diphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose 1,6-diphosphate phosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose bisphosphate phosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose diphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose diphosphate phosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose-1,6-bisphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "fructose-bisphosphatase activity" BROAD [EC:3.1.3.00] +synonym: "hexose bisphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "hexose diphosphatase activity" RELATED [EC:3.1.3.11] +synonym: "hexosediphosphatase activity" BROAD [EC:3.1.3.11] +xref: EC:3.1.3.11 +xref: MetaCyc:F16BDEPHOS-RXN +xref: Reactome:R-HSA-70479 "D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate" +xref: RHEA:11064 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0042133 +name: neurotransmitter metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] +subset: goslim_pir +synonym: "neurotransmitter metabolism" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042134 +name: rRNA primary transcript binding +namespace: molecular_function +def: "Binding to an unprocessed ribosomal RNA transcript." [GOC:jl] +synonym: "pre-rRNA binding" EXACT [PMID:3327689] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0042135 +name: neurotransmitter catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] +subset: goslim_synapse +synonym: "neurotransmitter breakdown" EXACT [] +synonym: "neurotransmitter catabolism" EXACT [] +synonym: "neurotransmitter degradation" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042136 +name: neurotransmitter biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] +subset: goslim_synapse +synonym: "neurotransmitter anabolism" EXACT [] +synonym: "neurotransmitter biosynthesis" EXACT [] +synonym: "neurotransmitter biosynthesis and storage" BROAD [] +synonym: "neurotransmitter biosynthetic process and storage" BROAD [] +synonym: "neurotransmitter formation" EXACT [] +synonym: "neurotransmitter synthesis" EXACT [] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0042137 +name: sequestering of neurotransmitter +namespace: biological_process +def: "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai] +synonym: "neurotransmitter biosynthesis and storage" RELATED [] +synonym: "neurotransmitter biosynthetic process and storage" RELATED [] +synonym: "neurotransmitter retention" EXACT [] +synonym: "neurotransmitter sequestration" EXACT [] +synonym: "neurotransmitter storage" EXACT [] +synonym: "retention of neurotransmitter" EXACT [] +synonym: "sequestration of neurotransmitter" EXACT [] +synonym: "storage of neurotransmitter" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0042138 +name: meiotic DNA double-strand break formation +namespace: biological_process +def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] +is_a: GO:0061982 ! meiosis I cell cycle process +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis + +[Term] +id: GO:0042139 +name: early meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324] +is_a: GO:0007146 ! meiotic recombination nodule assembly + +[Term] +id: GO:0042140 +name: late meiotic recombination nodule assembly +namespace: biological_process +def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324] +is_a: GO:0007146 ! meiotic recombination nodule assembly + +[Term] +id: GO:0042141 +name: obsolete mating pheromone exporter +namespace: molecular_function +def: "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl] +comment: This term was made obsolete because it is too gene product specific. +synonym: "mating pheromone exporter" EXACT [] +is_obsolete: true +consider: GO:0042626 +consider: GO:0043190 + +[Term] +id: GO:0042142 +name: obsolete heavy metal chelation +namespace: biological_process +def: "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653] +comment: This term was made obsolete because it represents a molecular function and not a biological process. +synonym: "heavy metal chelation" EXACT [] +is_obsolete: true +replaced_by: GO:0046911 + +[Term] +id: GO:0042144 +name: vacuole fusion, non-autophagic +namespace: biological_process +alt_id: GO:0042145 +def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl] +synonym: "homotypic vacuole fusion" EXACT [] +synonym: "homotypic vacuole fusion (non-autophagic)" EXACT [] +synonym: "homotypic vacuole fusion, non-autophagic" EXACT [] +synonym: "vacuole fusion (non-autophagic)" EXACT [] +is_a: GO:0097576 ! vacuole fusion + +[Term] +id: GO:0042147 +name: retrograde transport, endosome to Golgi +namespace: biological_process +def: "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697] +synonym: "retrograde (endosome to Golgi) transport" EXACT [] +is_a: GO:0016197 ! endosomal transport +is_a: GO:0016482 ! cytosolic transport + +[Term] +id: GO:0042148 +name: strand invasion +namespace: biological_process +def: "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855] +synonym: "D-loop biosynthesis" RELATED [] +synonym: "D-loop formation" RELATED [] +synonym: "displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] +synonym: "displacement loop formation" RELATED [GOC:mah, GOC:vw] +synonym: "Rad51-mediated strand invasion" EXACT [GOC:elh] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0042149 +name: cellular response to glucose starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0042150 +name: plasmid recombination +namespace: biological_process +def: "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0042151 +name: nematocyst +namespace: cellular_component +def: "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl] +synonym: "cnidocyst" EXACT [] +xref: Wikipedia:Cnidocyte +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0042152 +name: RNA-mediated DNA recombination +namespace: biological_process +def: "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:0042153 +name: obsolete RPTP-like protein binding +namespace: molecular_function +def: "OBSOLETE. Binding to proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "receptor protein tyrosine phosphatase-like protein binding" EXACT [] +synonym: "RPTP-like protein binding" EXACT [] +is_obsolete: true +replaced_by: GO:0005515 + +[Term] +id: GO:0042156 +name: obsolete zinc-mediated transcriptional activator activity +namespace: molecular_function +def: "OBSOLETE. Initiates or upregulates transcription in the presence of zinc." [GOC:jl] +comment: This term was obsoleted because it is defined as a Process term, i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. +synonym: "zinc-mediated transcriptional activator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0042157 +name: lipoprotein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] +synonym: "lipoprotein metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:0042158 +name: lipoprotein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] +subset: goslim_pombe +synonym: "lipoprotein anabolism" EXACT [] +synonym: "lipoprotein biosynthesis" EXACT [] +synonym: "lipoprotein formation" EXACT [] +synonym: "lipoprotein synthesis" EXACT [] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0042157 ! lipoprotein metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042159 +name: lipoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids." [ISBN:0198506732] +synonym: "lipoprotein breakdown" EXACT [] +synonym: "lipoprotein catabolism" EXACT [] +synonym: "lipoprotein degradation" EXACT [] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0042160 +name: lipoprotein modification +namespace: biological_process +def: "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah] +is_a: GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0042161 +name: lipoprotein oxidation +namespace: biological_process +def: "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah] +is_a: GO:0042160 ! lipoprotein modification + +[Term] +id: GO:0042162 +name: telomeric DNA binding +namespace: molecular_function +def: "Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624] +synonym: "telomere binding" EXACT [] +synonym: "telomeric repeat binding" EXACT [] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0042163 +name: interleukin-12 beta subunit binding +namespace: molecular_function +def: "Binding to the beta subunit of interleukin-12." [GOC:mah] +synonym: "CLMFp40 binding" EXACT [] +synonym: "IL-12B binding" EXACT [] +synonym: "IL-12p40 binding" EXACT [] +synonym: "NKSFp40 binding" EXACT [] +is_a: GO:0019972 ! interleukin-12 binding + +[Term] +id: GO:0042164 +name: interleukin-12 alpha subunit binding +namespace: molecular_function +def: "Binding to the alpha subunit of interleukin-12." [GOC:mah] +synonym: "CLMFp35 binding" EXACT [] +synonym: "IL-12A binding" EXACT [] +synonym: "IL-12p35 binding" EXACT [] +synonym: "NKSFp35 binding" EXACT [] +is_a: GO:0019972 ! interleukin-12 binding + +[Term] +id: GO:0042165 +name: neurotransmitter binding +namespace: molecular_function +def: "Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042166 +name: acetylcholine binding +namespace: molecular_function +def: "Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] +is_a: GO:0042165 ! neurotransmitter binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0042167 +name: heme catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl] +synonym: "haem catabolic process" EXACT [] +synonym: "haem catabolism" EXACT [] +synonym: "heme breakdown" EXACT [] +synonym: "heme catabolism" EXACT [] +synonym: "heme degradation" EXACT [] +is_a: GO:0006787 ! porphyrin-containing compound catabolic process +is_a: GO:0042168 ! heme metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0042168 +name: heme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653] +synonym: "haem metabolic process" EXACT [] +synonym: "haem metabolism" EXACT [] +synonym: "heme metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0042169 +name: SH2 domain binding +namespace: molecular_function +def: "Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0042170 +name: plastid membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a plastid and form the plastid envelope." [GOC:mah] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0009526 ! plastid envelope + +[Term] +id: GO:0042171 +name: lysophosphatidic acid acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050] +synonym: "LPAAT activity" EXACT [PMID:16369050] +is_a: GO:0071617 ! lysophospholipid acyltransferase activity + +[Term] +id: GO:0042173 +name: regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore formation." [GOC:jl] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0042174 +name: negative regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators] +synonym: "down regulation of sporulation" EXACT [] +synonym: "down-regulation of sporulation" EXACT [] +synonym: "downregulation of sporulation" EXACT [] +synonym: "inhibition of sporulation" NARROW [] +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: negatively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0042175 +name: nuclear outer membrane-endoplasmic reticulum membrane network +namespace: cellular_component +def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] +synonym: "NE-ER continuum" RELATED [] +synonym: "NE-ER network" RELATED [] +synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] +synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] +synonym: "nuclear envelope-ER network" RELATED [] +synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] +synonym: "nuclear membrane-ER network" EXACT [GOC:mah] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:0042176 +name: regulation of protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] +synonym: "regulation of protein breakdown" EXACT [] +synonym: "regulation of protein catabolism" EXACT [] +synonym: "regulation of protein degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0042177 +name: negative regulation of protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076] +synonym: "down regulation of protein catabolic process" EXACT [] +synonym: "down-regulation of protein catabolic process" EXACT [] +synonym: "downregulation of protein catabolic process" EXACT [] +synonym: "inhibition of protein catabolic process" NARROW [] +synonym: "negative regulation of protein breakdown" EXACT [] +synonym: "negative regulation of protein catabolism" EXACT [] +synonym: "negative regulation of protein degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0042178 +name: xenobiotic catabolic process +namespace: biological_process +alt_id: GO:0042737 +alt_id: GO:0042738 +def: "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:jl, GOC:krc] +synonym: "drug breakdown" RELATED [] +synonym: "drug catabolic process" RELATED [] +synonym: "drug catabolism" RELATED [] +synonym: "drug degradation" RELATED [] +synonym: "exogenous drug breakdown" RELATED [] +synonym: "exogenous drug catabolic process" RELATED [] +synonym: "exogenous drug catabolism" RELATED [] +synonym: "exogenous drug degradation" RELATED [] +synonym: "xenobiotic breakdown" EXACT [] +synonym: "xenobiotic catabolism" EXACT [] +synonym: "xenobiotic degradation" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042179 +name: nicotine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] +synonym: "nicotine anabolism" EXACT [] +synonym: "nicotine biosynthesis" EXACT [] +synonym: "nicotine formation" EXACT [] +synonym: "nicotine synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0018933 ! nicotine metabolic process + +[Term] +id: GO:0042180 +name: cellular ketone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] +subset: goslim_pir +synonym: "ketone metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0042181 +name: ketone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] +synonym: "ketone anabolism" EXACT [] +synonym: "ketone biosynthesis" EXACT [] +synonym: "ketone formation" EXACT [] +synonym: "ketone synthesis" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0042182 +name: ketone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] +synonym: "ketone breakdown" EXACT [] +synonym: "ketone catabolism" EXACT [] +synonym: "ketone degradation" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0042183 +name: formate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] +synonym: "formate breakdown" EXACT [] +synonym: "formate catabolism" EXACT [] +synonym: "formate degradation" EXACT [] +synonym: "formic acid catabolic process" EXACT [] +synonym: "formic acid catabolism" EXACT [] +is_a: GO:0015942 ! formate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0042184 +name: xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators] +synonym: "xylene breakdown" EXACT [] +synonym: "xylene catabolism" EXACT [] +synonym: "xylene degradation" EXACT [] +is_a: GO:0018948 ! xylene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0042185 +name: m-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl] +synonym: "m-xylene breakdown" EXACT [] +synonym: "m-xylene catabolism" EXACT [] +synonym: "m-xylene degradation" EXACT [] +synonym: "meta-xylene catabolic process" EXACT [] +synonym: "meta-xylene catabolism" EXACT [] +xref: MetaCyc:PWY-142 +is_a: GO:0018949 ! m-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042186 +name: o-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] +synonym: "o-xylene breakdown" EXACT [] +synonym: "o-xylene catabolism" EXACT [] +synonym: "o-xylene degradation" EXACT [] +synonym: "ortho-xylene catabolic process" EXACT [] +synonym: "ortho-xylene catabolism" EXACT [] +is_a: GO:0018950 ! o-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042187 +name: p-xylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl] +synonym: "p-xylene breakdown" EXACT [] +synonym: "p-xylene catabolism" EXACT [] +synonym: "p-xylene degradation" EXACT [] +synonym: "para-xylene catabolic process" EXACT [] +synonym: "para-xylene catabolism" EXACT [] +is_a: GO:0018951 ! p-xylene metabolic process +is_a: GO:0042184 ! xylene catabolic process + +[Term] +id: GO:0042188 +name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown" EXACT [] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism" EXACT [] +synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation" EXACT [] +synonym: "DDT catabolic process" EXACT [] +synonym: "DDT catabolism" EXACT [] +is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process +is_a: GO:0046701 ! insecticide catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0042189 +name: vanillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] +synonym: "vanillic aldehyde biosynthesis" EXACT [] +synonym: "vanillic aldehyde biosynthetic process" EXACT [] +synonym: "vanillin anabolism" EXACT [] +synonym: "vanillin biosynthesis" EXACT [] +synonym: "vanillin formation" EXACT [] +synonym: "vanillin synthesis" EXACT [] +is_a: GO:0018982 ! vanillin metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0042190 +name: vanillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl] +synonym: "vanillic aldehyde catabolic process" EXACT [] +synonym: "vanillic aldehyde catabolism" EXACT [] +synonym: "vanillin breakdown" EXACT [] +synonym: "vanillin catabolism" EXACT [] +synonym: "vanillin degradation" EXACT [] +is_a: GO:0018982 ! vanillin metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0042191 +name: methylmercury metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai] +synonym: "methylmercury metabolism" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process + +[Term] +id: GO:0042192 +name: methylmercury biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] +synonym: "methylmercury anabolism" EXACT [] +synonym: "methylmercury biosynthesis" EXACT [] +synonym: "methylmercury formation" EXACT [] +synonym: "methylmercury synthesis" EXACT [] +is_a: GO:0042191 ! methylmercury metabolic process +is_a: GO:0046414 ! organomercury biosynthetic process + +[Term] +id: GO:0042193 +name: methylmercury catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai] +synonym: "methylmercury breakdown" EXACT [] +synonym: "methylmercury catabolism" EXACT [] +synonym: "methylmercury degradation" EXACT [] +is_a: GO:0042191 ! methylmercury metabolic process +is_a: GO:0046413 ! organomercury catabolic process + +[Term] +id: GO:0042194 +name: quinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators] +synonym: "quinate anabolism" EXACT [] +synonym: "quinate biosynthesis" EXACT [] +synonym: "quinate formation" EXACT [] +synonym: "quinate synthesis" EXACT [] +synonym: "quinic acid biosynthesis" EXACT [] +synonym: "quinic acid biosynthetic process" EXACT [] +is_a: GO:0019630 ! quinate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0042195 +name: aerobic gallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl] +synonym: "aerobic gallate breakdown" EXACT [] +synonym: "aerobic gallate catabolism" EXACT [] +synonym: "aerobic gallate degradation" EXACT [] +synonym: "aerobic gallic acid catabolic process" EXACT [] +synonym: "aerobic gallic acid catabolism" EXACT [] +is_a: GO:0019396 ! gallate catabolic process + +[Term] +id: GO:0042196 +name: chlorinated hydrocarbon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms." [GOC:ai, GOC:krc] +synonym: "chlorinated hydrocarbon metabolism" EXACT [] +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process + +[Term] +id: GO:0042197 +name: halogenated hydrocarbon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai, GOC:krc] +synonym: "halogenated hydrocarbon metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0042198 +name: nylon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549] +synonym: "nylon metabolism" EXACT [] +is_a: GO:0006805 ! xenobiotic metabolic process + +[Term] +id: GO:0042199 +name: cyanuric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya] +synonym: "cyanuric acid metabolism" EXACT [] +is_a: GO:0018965 ! s-triazine compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042200 +name: cyanuric acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [UM-BBD_pathwayID:cya] +synonym: "cyanuric acid breakdown" EXACT [] +synonym: "cyanuric acid catabolism" EXACT [] +synonym: "cyanuric acid degradation" EXACT [] +xref: UM-BBD_pathwayID:cya +is_a: GO:0042199 ! cyanuric acid metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0042201 +name: N-cyclopropylmelamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [UM-BBD_pathwayID:cpm] +synonym: "cyromazine metabolic process" EXACT [] +synonym: "cyromazine metabolism" EXACT [] +synonym: "N-cyclopropylmelamine metabolism" EXACT [] +is_a: GO:0018965 ! s-triazine compound metabolic process + +[Term] +id: GO:0042202 +name: N-cyclopropylmelamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [UM-BBD_pathwayID:cpm] +synonym: "cyromazine catabolic process" EXACT [] +synonym: "cyromazine catabolism" EXACT [] +synonym: "N-cyclopropylmelamine breakdown" EXACT [] +synonym: "N-cyclopropylmelamine catabolism" EXACT [] +synonym: "N-cyclopropylmelamine degradation" EXACT [] +xref: UM-BBD_pathwayID:cpm +is_a: GO:0042201 ! N-cyclopropylmelamine metabolic process +is_a: GO:0042204 ! s-triazine compound catabolic process + +[Term] +id: GO:0042203 +name: toluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators] +synonym: "toluene breakdown" EXACT [] +synonym: "toluene catabolism" EXACT [] +synonym: "toluene degradation" EXACT [] +is_a: GO:0018970 ! toluene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process + +[Term] +id: GO:0042204 +name: s-triazine compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria] +synonym: "s-triazine compound breakdown" EXACT [] +synonym: "s-triazine compound catabolism" EXACT [] +synonym: "s-triazine compound degradation" EXACT [] +xref: UM-BBD_pathwayID:tria +is_a: GO:0018965 ! s-triazine compound metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042205 +name: chlorinated hydrocarbon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms." [GOC:ai, GOC:krc] +synonym: "chlorinated hydrocarbon breakdown" EXACT [] +synonym: "chlorinated hydrocarbon catabolism" EXACT [] +synonym: "chlorinated hydrocarbon degradation" EXACT [] +is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process +is_a: GO:0042206 ! halogenated hydrocarbon catabolic process + +[Term] +id: GO:0042206 +name: halogenated hydrocarbon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms." [GOC:ai, GOC:krc] +synonym: "halogenated hydrocarbon breakdown" EXACT [] +synonym: "halogenated hydrocarbon catabolism" EXACT [] +synonym: "halogenated hydrocarbon degradation" EXACT [] +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042197 ! halogenated hydrocarbon metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0042207 +name: styrene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl] +synonym: "styrene breakdown" EXACT [] +synonym: "styrene catabolism" EXACT [] +synonym: "styrene degradation" EXACT [] +xref: UM-BBD_pathwayID:sty +is_a: GO:0018966 ! styrene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0042208 +name: propylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl] +synonym: "propylene breakdown" EXACT [] +synonym: "propylene catabolism" EXACT [] +synonym: "propylene degradation" EXACT [] +xref: UM-BBD_pathwayID:pro +is_a: GO:0018964 ! propylene metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042209 +name: orcinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl] +synonym: "orcin catabolic process" EXACT [] +synonym: "orcin catabolism" EXACT [] +synonym: "orcinol breakdown" EXACT [] +synonym: "orcinol catabolism" EXACT [] +synonym: "orcinol degradation" EXACT [] +xref: UM-BBD_pathwayID:orc +is_a: GO:0018940 ! orcinol metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process + +[Term] +id: GO:0042210 +name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl] +synonym: "catabolic process of octamethylcyclotetrasiloxane to DMSD" EXACT [] +synonym: "catabolism of octamethylcyclotetrasiloxane to DMSD" EXACT [] +synonym: "octamethylcyclotetrasiloxane breakdown to dimethylsilanediol" EXACT [] +synonym: "octamethylcyclotetrasiloxane degradation to dimethylsilanediol" EXACT [] +xref: UM-BBD_pathwayID:osi +is_a: GO:0018947 ! anaerobic organosilicon metabolic process +is_a: GO:0046454 ! dimethylsilanediol metabolic process +is_a: GO:0046517 ! octamethylcyclotetrasiloxane catabolic process + +[Term] +id: GO:0042211 +name: dimethylsilanediol catabolic process +namespace: biological_process +def: "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl] +synonym: "catabolic process of DMSD" EXACT [] +synonym: "catabolism of DMSD" EXACT [] +synonym: "degradation of dimethylsilanediol" EXACT [] +synonym: "dimethylsilanediol breakdown" EXACT [] +synonym: "dimethylsilanediol catabolism" EXACT [] +synonym: "dimethylsilanediol degradation" EXACT [] +is_a: GO:0018946 ! aerobic organosilicon metabolic process +is_a: GO:0046454 ! dimethylsilanediol metabolic process +is_a: GO:0046455 ! organosilicon catabolic process + +[Term] +id: GO:0042212 +name: cresol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [UM-BBD_pathwayID:mcr] +synonym: "cresol metabolism" EXACT [] +synonym: "hydroxytoluene metabolic process" EXACT [] +synonym: "hydroxytoluene metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process + +[Term] +id: GO:0042213 +name: m-cresol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl] +synonym: "3-hydroxytoluene catabolic process" EXACT [] +synonym: "3-hydroxytoluene catabolism" EXACT [] +synonym: "m-cresol breakdown" EXACT [] +synonym: "m-cresol catabolism" EXACT [] +synonym: "m-cresol degradation" EXACT [] +synonym: "meta-cresol catabolic process" EXACT [] +synonym: "meta-cresol catabolism" EXACT [] +xref: MetaCyc:M-CRESOL-DEGRADATION-PWY +xref: UM-BBD_pathwayID:mcr +is_a: GO:0018925 ! m-cresol metabolic process +is_a: GO:0046199 ! cresol catabolic process + +[Term] +id: GO:0042214 +name: terpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [GOC:curators] +synonym: "terpene metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0042215 +name: anaerobic phenol-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [PMID:12697029] +synonym: "anaerobic phenol-containing compound metabolism" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0042216 +name: phenanthrene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl] +synonym: "phenanthrene breakdown" EXACT [] +synonym: "phenanthrene catabolism" EXACT [] +synonym: "phenanthrene degradation" EXACT [] +xref: UM-BBD_pathwayID:phe +is_a: GO:0018955 ! phenanthrene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0042217 +name: 1-aminocyclopropane-1-carboxylate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] +synonym: "1-aminocyclopropane-1-carboxylate breakdown" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate catabolism" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0042218 +name: 1-aminocyclopropane-1-carboxylate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators] +synonym: "1-aminocyclopropane-1-carboxylate anabolism" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate biosynthesis" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate formation" EXACT [] +synonym: "1-aminocyclopropane-1-carboxylate synthesis" EXACT [] +is_a: GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0042219 +name: cellular modified amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +synonym: "amino acid derivative catabolic process" EXACT [] +synonym: "cellular amino acid derivative breakdown" EXACT [] +synonym: "cellular amino acid derivative catabolic process" EXACT [] +synonym: "cellular amino acid derivative catabolism" EXACT [] +synonym: "cellular amino acid derivative degradation" EXACT [] +synonym: "cellular modified amino acid breakdown" EXACT [GOC:mah] +synonym: "cellular modified amino acid catabolism" EXACT [GOC:mah] +synonym: "cellular modified amino acid degradation" EXACT [GOC:mah] +synonym: "modified amino acid catabolic process" EXACT [GOC:mah] +synonym: "modified amino acid catabolism" EXACT [GOC:mah] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042220 +name: response to cocaine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:ef, GOC:jl] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043279 ! response to alkaloid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0042221 +name: response to chemical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_metagenomics +subset: goslim_plant +subset: goslim_yeast +synonym: "response to chemical stimulus" EXACT [GOC:dos] +synonym: "response to chemical substance" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0042242 +name: cobyrinic acid a,c-diamide synthase activity +namespace: molecular_function +alt_id: GO:0043775 +def: "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209, RHEA:26289] +synonym: "CobB" NARROW [] +synonym: "cobyrinate a c diamide synthase activity" EXACT [] +synonym: "cobyrinate a c-diamide synthase activity" EXACT [] +synonym: "cobyrinate a,c diamide synthase activity" EXACT [] +synonym: "cobyrinate a,c-diamide synthase activity" EXACT [] +xref: EC:6.3.5.11 +xref: RHEA:26289 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0042243 +name: asexual spore wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species." [GOC:mah] +synonym: "asexual spore wall formation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0042244 ! spore wall assembly +relationship: part_of GO:0030436 ! asexual sporulation + +[Term] +id: GO:0042244 +name: spore wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] +synonym: "spore coat biosynthesis" EXACT [] +synonym: "spore coat biosynthetic process" EXACT [] +synonym: "spore wall formation" EXACT [] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0070726 ! cell wall assembly +relationship: part_of GO:0070590 ! spore wall biogenesis + +[Term] +id: GO:0042245 +name: RNA repair +namespace: biological_process +def: "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0042246 +name: tissue regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed tissues." [GOC:curators] +is_a: GO:0031099 ! regeneration +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0042247 +name: establishment of planar polarity of follicular epithelium +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] +is_a: GO:0001736 ! establishment of planar polarity +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium + +[Term] +id: GO:0042248 +name: maintenance of polarity of follicular epithelium +namespace: biological_process +def: "The maintenance of an established polarized follicular epithelial sheet." [GOC:bf] +is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium + +[Term] +id: GO:0042249 +name: establishment of planar polarity of embryonic epithelium +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0042250 +name: maintenance of polarity of embryonic epithelium +namespace: biological_process +def: "The maintenance of an established polarized embryonic epithelial sheet." [GOC:jl] +is_a: GO:0016332 ! establishment or maintenance of polarity of embryonic epithelium + +[Term] +id: GO:0042251 +name: maintenance of polarity of larval imaginal disc epithelium +namespace: biological_process +def: "The maintenance of an established polarized larval imaginal disc epithelium." [GOC:jl] +is_a: GO:0016336 ! establishment or maintenance of polarity of larval imaginal disc epithelium + +[Term] +id: GO:0042252 +name: establishment of planar polarity of larval imaginal disc epithelium +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0042254 +name: ribosome biogenesis +namespace: biological_process +alt_id: GO:0007046 +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +synonym: "ribosome biogenesis and assembly" EXACT [] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis + +[Term] +id: GO:0042255 +name: ribosome assembly +namespace: biological_process +alt_id: GO:0042257 +def: "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma] +subset: goslim_yeast +synonym: "ribosomal subunit assembly" NARROW [GOC:mah, GOC:vw] +is_a: GO:0140694 ! non-membrane-bounded organelle assembly +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042256 +name: mature ribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma] +is_a: GO:0042255 ! ribosome assembly + +[Term] +id: GO:0042258 +name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319] +xref: RESID:AA0319 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0042259 +name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine +namespace: biological_process +def: "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320] +synonym: "peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine" EXACT [] +synonym: "peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine" EXACT [] +xref: RESID:AA0320 +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0042262 +name: DNA protection +namespace: biological_process +def: "Any process in which DNA is protected from damage by, for example, oxidative stress." [GOC:jl] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0031668 ! cellular response to extracellular stimulus +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0042263 +name: neuropeptide F receptor activity +namespace: molecular_function +def: "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021] +comment: Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. +synonym: "NPF receptor activity" EXACT [PMID:21440021] +is_a: GO:0008188 ! neuropeptide receptor activity + +[Term] +id: GO:0042264 +name: peptidyl-aspartic acid hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid." [GOC:mah] +synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0042265 +name: peptidyl-asparagine hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine." [GOC:mah] +synonym: "peptidyl-aspartic acid/asparagine hydroxylation" BROAD [] +is_a: GO:0018126 ! protein hydroxylation +is_a: GO:0018196 ! peptidyl-asparagine modification + +[Term] +id: GO:0042267 +name: natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr] +comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. +synonym: "killer activity" RELATED [] +synonym: "natural killer cell mediated cell death" EXACT [] +synonym: "natural killer cell mediated cell killing" EXACT [] +synonym: "natural killer cell mediated cytolysis" RELATED [] +synonym: "natural killer-cell mediated cytolysis" RELATED [] +synonym: "NK cell mediated cell death" EXACT [] +synonym: "NK cell mediated cell killing" EXACT [] +synonym: "NK cell mediated cytolysis" RELATED [] +synonym: "NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002228 ! natural killer cell mediated immunity + +[Term] +id: GO:0042268 +name: regulation of cytolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, GOC:mtg_apoptosis] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0042269 +name: regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "regulation of natural killer cell mediated cell death" EXACT [] +synonym: "regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "regulation of natural killer-cell mediated cytolysis" RELATED [] +synonym: "regulation of NK cell mediated cell death" EXACT [] +synonym: "regulation of NK cell mediated cell killing" EXACT [] +synonym: "regulation of NK cell mediated cytolysis" RELATED [] +synonym: "regulation of NK cell mediated cytotoxicity" RELATED [] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002715 ! regulation of natural killer cell mediated immunity +relationship: regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042270 +name: protection from natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "protection from natural killer cell mediated cell death" EXACT [] +synonym: "protection from natural killer cell mediated cell killing" EXACT [] +synonym: "protection from natural killer cell mediated cytolysis" RELATED [] +synonym: "protection from NK cell mediated cell death" EXACT [] +synonym: "protection from NK cell mediated cell killing" EXACT [] +synonym: "protection from NK cell mediated cytolysis" RELATED [] +synonym: "protection from NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042271 +name: susceptibility to natural killer cell mediated cytotoxicity +namespace: biological_process +def: "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +comment: Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity. +synonym: "susceptibility to natural killer cell mediated cell death" EXACT [] +synonym: "susceptibility to natural killer cell mediated cell killing" EXACT [] +synonym: "susceptibility to natural killer cell mediated cytolysis" RELATED [] +synonym: "susceptibility to NK cell mediated cell death" EXACT [] +synonym: "susceptibility to NK cell mediated cell killing" EXACT [] +synonym: "susceptibility to NK cell mediated cytolysis" EXACT [] +synonym: "susceptibility to NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity + +[Term] +id: GO:0042272 +name: nuclear RNA export factor complex +namespace: cellular_component +def: "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633] +synonym: "Mex67-Mtr2 complex" EXACT [] +synonym: "NXF1-NXT1 complex" EXACT [] +synonym: "TAP-p15 complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0042273 +name: ribosomal large subunit biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] +subset: goslim_yeast +synonym: "ribosomal large subunit biogenesis and assembly" EXACT [] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042274 +name: ribosomal small subunit biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl] +subset: goslim_yeast +synonym: "ribosomal small subunit biogenesis and assembly" EXACT [] +is_a: GO:0022613 ! ribonucleoprotein complex biogenesis +relationship: part_of GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0042275 +name: error-free postreplication DNA repair +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630] +comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. +synonym: "error-free PRR" EXACT [] +synonym: "error-free replication restart" RELATED [] +is_a: GO:0006301 ! postreplication repair + +[Term] +id: GO:0042276 +name: error-prone translesion synthesis +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998] +synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh] +synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh] +synonym: "mutagenic PRR" EXACT [] +is_a: GO:0019985 ! translesion synthesis + +[Term] +id: GO:0042277 +name: peptide binding +namespace: molecular_function +def: "Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds." [GOC:jl] +subset: goslim_chembl +subset: goslim_pir +is_a: GO:0033218 ! amide binding + +[Term] +id: GO:0042278 +name: purine nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] +synonym: "purine metabolic process" BROAD [] +synonym: "purine metabolism" BROAD [] +synonym: "purine nucleoside metabolism" EXACT [] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0042279 +name: nitrite reductase (cytochrome, ammonia-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2] +synonym: "ammonia:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.7.2.2] +synonym: "cytochrome c nitrite reductase activity" EXACT [] +synonym: "cytochrome c552 activity" NARROW [EC:1.7.2.2] +synonym: "multiheme nitrite reductase activity" EXACT [] +synonym: "nitrite reductase (cytochrome; ammonia-forming)" RELATED [EC:1.7.2.2] +xref: EC:1.7.2.2 +xref: MetaCyc:1.7.2.2-RXN +xref: RHEA:13089 +xref: Wikipedia:Cytochrome_c_nitrite_reductase +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor +is_a: GO:0098809 ! nitrite reductase activity + +[Term] +id: GO:0042280 +name: obsolete cell surface antigen activity, host-interacting +namespace: molecular_function +def: "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb] +comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. +synonym: "cell surface antigen activity, host-interacting" EXACT [] +is_obsolete: true +consider: GO:0044403 +consider: GO:0046789 + +[Term] +id: GO:0042281 +name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470] +synonym: "dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.267 +xref: MetaCyc:RXN-5470 +xref: RHEA:30635 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0042283 +name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927] +synonym: "dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.265 +xref: MetaCyc:RXN-5471 +xref: RHEA:31307 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0042284 +name: sphingolipid delta-4 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O." [PMID:12417141, RHEA:46544] +synonym: "delta-4 sphingolipid desaturase activity" EXACT [] +xref: EC:1.14.19.17 +xref: Reactome:R-HSA-428259 "dihydroceramide + NAD(P)H + H+ + O2 => ceramide + NAD(P)+ + H2O" +xref: RHEA:46544 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0042285 +name: xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0042286 +name: glutamate-1-semialdehyde 2,1-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8, RHEA:14265] +synonym: "(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity" RELATED [EC:5.4.3.8] +synonym: "glutamate-1-semialdehyde aminotransferase activity" RELATED [EC:5.4.3.8] +xref: EC:5.4.3.8 +xref: KEGG_REACTION:R02272 +xref: MetaCyc:GSAAMINOTRANS-RXN +xref: RHEA:14265 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0042287 +name: MHC protein binding +namespace: molecular_function +def: "Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "major histocompatibility complex binding" EXACT [] +synonym: "major histocompatibility complex ligand" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042288 +name: MHC class I protein binding +namespace: molecular_function +def: "Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "alpha-beta T cell receptor activity" RELATED [] +synonym: "gamma-delta T cell receptor activity" RELATED [] +synonym: "major histocompatibility complex class I binding" EXACT [] +synonym: "major histocompatibility complex class I ligand" NARROW [] +synonym: "T cell receptor activity" RELATED [] +is_a: GO:0042287 ! MHC protein binding + +[Term] +id: GO:0042289 +name: MHC class II protein binding +namespace: molecular_function +def: "Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl] +comment: Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. +synonym: "major histocompatibility complex class II binding" EXACT [] +synonym: "major histocompatibility complex class II ligand" NARROW [] +is_a: GO:0042287 ! MHC protein binding + +[Term] +id: GO:0042290 +name: obsolete URM1 hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +synonym: "URM1 hydrolase activity" EXACT [] +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0042291 +name: obsolete Hub1 hydrolase activity +namespace: molecular_function +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:mah] +comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. +synonym: "Hub1 hydrolase activity" EXACT [] +is_obsolete: true +consider: GO:0019783 + +[Term] +id: GO:0042292 +name: URM1 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0042293 +name: Hub1 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0042294 +name: URM1 transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages." [GOC:mah, PMID:12826404] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0042296 +name: ISG15 transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages." [GOC:mah, PMID:12826404] +synonym: "ISG15 conjugating enzyme activity" NARROW [] +xref: Reactome:R-HSA-5653754 "UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA" +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0042297 +name: vocal learning +namespace: biological_process +def: "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] +comment: Examples include language learning by human infants and song learning in zebra finches. +xref: Wikipedia:Vocal_learning +is_a: GO:0031223 ! auditory behavior +is_a: GO:0098596 ! imitative learning +is_a: GO:0098598 ! learned vocalization behavior or vocal learning + +[Term] +id: GO:0042299 +name: lupeol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589] +synonym: "oxidosqualene:lupeol cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.41 +xref: MetaCyc:RXN-111 +xref: RHEA:31383 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042300 +name: beta-amyrin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin." [PMID:9746369] +synonym: "oxidosqualene:beta-amyrin cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.- +xref: MetaCyc:RXN-7570 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042301 +name: phosphate ion binding +namespace: molecular_function +def: "Binding to a phosphate ion." [GOC:jl] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0042302 +name: structural constituent of cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a cuticle." [GOC:jl] +subset: goslim_drosophila +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0042303 +name: molting cycle +namespace: biological_process +def: "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0042304 +name: regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl] +synonym: "regulation of fatty acid anabolism" EXACT [] +synonym: "regulation of fatty acid biosynthesis" EXACT [] +synonym: "regulation of fatty acid formation" EXACT [] +synonym: "regulation of fatty acid synthesis" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042305 +name: specification of segmental identity, mandibular segment +namespace: biological_process +def: "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] +comment: See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'. +is_a: GO:0007380 ! specification of segmental identity, head +relationship: part_of GO:0035289 ! posterior head segmentation + +[Term] +id: GO:0042306 +name: regulation of protein import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] +synonym: "regulation of protein import into cell nucleus" EXACT [] +synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of protein-nucleus import" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +is_a: GO:1900180 ! regulation of protein localization to nucleus +is_a: GO:1904589 ! regulation of protein import +relationship: regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042307 +name: positive regulation of protein import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "activation of protein import into nucleus" NARROW [] +synonym: "positive regulation of protein import into cell nucleus" EXACT [] +synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of protein-nucleus import" EXACT [] +synonym: "stimulation of protein import into nucleus" NARROW [] +synonym: "up regulation of protein import into nucleus" EXACT [] +synonym: "up-regulation of protein import into nucleus" EXACT [] +synonym: "upregulation of protein import into nucleus" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1900182 ! positive regulation of protein localization to nucleus +is_a: GO:1904591 ! positive regulation of protein import +relationship: positively_regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042308 +name: negative regulation of protein import into nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "down regulation of protein import into nucleus" EXACT [] +synonym: "down-regulation of protein import into nucleus" EXACT [] +synonym: "downregulation of protein import into nucleus" EXACT [] +synonym: "inhibition of protein import into nucleus" NARROW [] +synonym: "negative regulation of protein import into cell nucleus" EXACT [] +synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of protein-nucleus import" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1900181 ! negative regulation of protein localization to nucleus +is_a: GO:1904590 ! negative regulation of protein import +relationship: negatively_regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042309 +name: homoiothermy +namespace: biological_process +def: "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023] +synonym: "antifreeze activity" RELATED [] +synonym: "ice nucleation activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0001659 ! temperature homeostasis + +[Term] +id: GO:0042310 +name: vasoconstriction +namespace: biological_process +alt_id: GO:0045908 +def: "A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure." [GOC:pr, ISBN:0192800752] +synonym: "negative regulation of blood vessel size" EXACT [] +xref: Wikipedia:Vasoconstriction +is_a: GO:0097746 ! blood vessel diameter maintenance + +[Term] +id: GO:0042311 +name: vasodilation +namespace: biological_process +alt_id: GO:0045909 +def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure." [GOC:pr, ISBN:0192800981] +synonym: "positive regulation of blood vessel size" EXACT [] +synonym: "vasodilatation" EXACT [] +xref: Wikipedia:Vasodilation +is_a: GO:0097746 ! blood vessel diameter maintenance + +[Term] +id: GO:0042313 +name: protein kinase C deactivation +namespace: biological_process +def: "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf] +synonym: "PKC deactivation" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway + +[Term] +id: GO:0042314 +name: bacteriochlorophyll binding +namespace: molecular_function +def: "Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981] +is_a: GO:0016168 ! chlorophyll binding + +[Term] +id: GO:0042315 +name: obsolete cytosol nonspecific dipeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18] +comment: This term was made obsolete because it represents a gene product. +synonym: "cytosol non-specific dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "cytosol nonspecific dipeptidase activity" EXACT [] +synonym: "diglycinase activity" RELATED [EC:3.4.13.18] +synonym: "Gly-Leu hydrolase activity" RELATED [EC:3.4.13.18] +synonym: "glycyl-glycine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "glycyl-L-leucine dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "glycyl-L-leucine hydrolase activity" RELATED [EC:3.4.13.18] +synonym: "glycyl-L-leucine peptidase activity" RELATED [EC:3.4.13.18] +synonym: "glycyl-leucine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "glycylleucine dipeptide hydrolase activity" RELATED [EC:3.4.13.18] +synonym: "glycylleucine hydrolase activity" RELATED [EC:3.4.13.18] +synonym: "glycylleucine peptidase activity" RELATED [EC:3.4.13.18] +synonym: "human cytosolic non-specific dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "iminodipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "L-amino-acyl-L-amino-acid hydrolase activity" RELATED [EC:3.4.13.18] +synonym: "L-prolylglycine dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "N(2)-beta-alanylarginine dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "N2-beta-alanylarginine dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "non-specific dipeptidase activity" RELATED [EC:3.4.13.18] +synonym: "peptidase A activity" BROAD [EC:3.4.13.18] +synonym: "Pro-X dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "prolinase activity" NARROW [EC:3.4.13.18] +synonym: "prolyl dipeptidase activity" NARROW [EC:3.4.13.18] +synonym: "prolylglycine dipeptidase activity" NARROW [EC:3.4.13.18] +is_obsolete: true +replaced_by: GO:0016805 + +[Term] +id: GO:0042316 +name: penicillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732] +synonym: "penicillin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0042317 +name: penicillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732] +synonym: "penicillin breakdown" EXACT [] +synonym: "penicillin catabolism" EXACT [] +synonym: "penicillin degradation" EXACT [] +is_a: GO:0030655 ! beta-lactam antibiotic catabolic process +is_a: GO:0042316 ! penicillin metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process + +[Term] +id: GO:0042318 +name: penicillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732] +synonym: "penicillin anabolism" EXACT [] +synonym: "penicillin biosynthesis" EXACT [] +synonym: "penicillin formation" EXACT [] +synonym: "penicillin synthesis" EXACT [] +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:0042316 ! penicillin metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0042320 +name: regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998] +synonym: "regulation of REM sleep" EXACT [] +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +relationship: regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0042321 +name: negative regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981] +synonym: "down regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "negative regulation of sleep" EXACT [] +is_a: GO:0042754 ! negative regulation of circadian rhythm +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042322 +name: negative regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl] +synonym: "down regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "negative regulation of REM sleep" EXACT [] +is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep +is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep +relationship: negatively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0042323 +name: negative regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl] +synonym: "down regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "down-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "downregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "inhibition of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "negative regulation of non-REM sleep" EXACT [] +is_a: GO:0042321 ! negative regulation of circadian sleep/wake cycle, sleep +is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep +relationship: negatively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0042324 +name: hypocretin receptor binding +namespace: molecular_function +def: "Binding to a hypocretin receptor." [GOC:ceb, PMID:11988773] +synonym: "hypocretin receptor ligand" NARROW [] +synonym: "orexin receptor binding" EXACT [] +synonym: "orexin receptor ligand" NARROW [] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0042325 +name: regulation of phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042326 +name: negative regulation of phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl] +synonym: "down regulation of phosphorylation" EXACT [] +synonym: "down-regulation of phosphorylation" EXACT [] +synonym: "downregulation of phosphorylation" EXACT [] +synonym: "inhibition of phosphorylation" NARROW [] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +relationship: negatively_regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042327 +name: positive regulation of phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl] +synonym: "activation of phosphorylation" NARROW [] +synonym: "stimulation of phosphorylation" NARROW [] +synonym: "up regulation of phosphorylation" EXACT [] +synonym: "up-regulation of phosphorylation" EXACT [] +synonym: "upregulation of phosphorylation" EXACT [] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +relationship: positively_regulates GO:0016310 ! phosphorylation + +[Term] +id: GO:0042328 +name: heparan sulfate N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma] +synonym: "heparan sulphate N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "heparin N-acetylglucosaminyltransferase activity" RELATED [] +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0042329 +name: structural constituent of collagen and cuticulin-based cuticle +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] +synonym: "structural constituent of cuticle" BROAD [] +is_a: GO:0042302 ! structural constituent of cuticle + +[Term] +id: GO:0042330 +name: taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023] +synonym: "directed movement in response to stimulus" EXACT [] +xref: Wikipedia:Taxis +is_a: GO:0040011 ! locomotion +relationship: part_of GO:0009605 ! response to external stimulus + +[Term] +id: GO:0042331 +name: phototaxis +namespace: biological_process +alt_id: GO:0046953 +def: "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981] +synonym: "phototactic behavior" EXACT [] +synonym: "phototactic behaviour" EXACT [] +synonym: "taxis in response to light" EXACT [] +xref: Wikipedia:Phototaxis +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042332 +name: gravitaxis +namespace: biological_process +alt_id: GO:0048062 +def: "The directed movement of a motile cell or organism in response to gravity." [GOC:jid, GOC:jl] +synonym: "geotactic behavior" EXACT [] +synonym: "geotactic behaviour" EXACT [] +synonym: "geotaxis" EXACT [] +synonym: "gravitactic behavior" EXACT [] +synonym: "gravitactic behaviour" EXACT [] +synonym: "taxis in response to gravitational stimulus" EXACT [] +synonym: "taxis in response to gravity" EXACT [] +is_a: GO:0009629 ! response to gravity +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0042333 +name: chemotaxis to oxidizable substrate +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423] +synonym: "taxis in response to oxidizable substrate" EXACT [] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042334 +name: taxis to electron acceptor +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423] +synonym: "taxis in response to electron acceptor" EXACT [] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0042335 +name: cuticle development +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825] +subset: goslim_drosophila +synonym: "cuticle anabolism" EXACT [] +synonym: "cuticle biosynthesis" EXACT [] +synonym: "cuticle biosynthetic process" EXACT [] +synonym: "cuticle formation" EXACT [] +synonym: "cuticle synthesis" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0042336 +name: obsolete cuticle development involved in protein-based cuticle molting cycle +namespace: biological_process +def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb] +comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. +synonym: "cuticle anabolism during molting" BROAD [] +synonym: "cuticle biosynthetic process during molting" BROAD [] +synonym: "cuticle development involved in protein-based cuticle molting cycle" EXACT [] +synonym: "cuticle formation during molting" BROAD [] +synonym: "cuticle synthesis during molting" BROAD [] +is_obsolete: true +consider: GO:0042337 +consider: GO:0042338 + +[Term] +id: GO:0042337 +name: cuticle development involved in chitin-based cuticle molting cycle +namespace: biological_process +def: "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb] +synonym: "chitin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] +synonym: "cuticle anabolism during molting" BROAD [] +synonym: "cuticle biosynthetic process during molting" BROAD [] +synonym: "cuticle formation during molting" BROAD [] +synonym: "cuticle synthesis during molting" BROAD [] +is_a: GO:0040003 ! chitin-based cuticle development +relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle + +[Term] +id: GO:0042338 +name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle +namespace: biological_process +def: "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu] +synonym: "collagen and cuticulin-based cuticle development during molting" RELATED [GOC:dph, GOC:tb] +synonym: "cuticle anabolism during molting" BROAD [] +synonym: "cuticle biosynthetic process during molting" BROAD [] +synonym: "cuticle formation during molting" BROAD [] +synonym: "cuticle synthesis during molting" BROAD [] +is_a: GO:0040002 ! collagen and cuticulin-based cuticle development +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0042339 +name: keratan sulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] +synonym: "keratan sulfate metabolism" EXACT [] +synonym: "keratan sulphate metabolic process" EXACT [] +synonym: "keratan sulphate metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1903510 ! mucopolysaccharide metabolic process + +[Term] +id: GO:0042340 +name: keratan sulfate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators] +synonym: "keratan sulfate breakdown" EXACT [] +synonym: "keratan sulfate catabolism" EXACT [] +synonym: "keratan sulfate degradation" EXACT [] +synonym: "keratan sulphate catabolic process" EXACT [] +synonym: "keratan sulphate catabolism" EXACT [] +is_a: GO:0006027 ! glycosaminoglycan catabolic process +is_a: GO:0042339 ! keratan sulfate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0042341 +name: cyanogenic glycoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] +synonym: "cyanogenic glycoside metabolism" EXACT [] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0050898 ! nitrile metabolic process + +[Term] +id: GO:0042342 +name: cyanogenic glycoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] +synonym: "cyanogenic glycoside breakdown" EXACT [] +synonym: "cyanogenic glycoside catabolism" EXACT [] +synonym: "cyanogenic glycoside degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0042341 ! cyanogenic glycoside metabolic process +is_a: GO:0050899 ! nitrile catabolic process + +[Term] +id: GO:0042343 +name: indole glucosinolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [GOC:curators] +synonym: "indole glucosinolate metabolism" EXACT [] +is_a: GO:0019760 ! glucosinolate metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:0042344 +name: indole glucosinolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [PMID:29122987] +synonym: "indole glucosinolate breakdown" EXACT [] +synonym: "indole glucosinolate catabolism" EXACT [] +synonym: "indole glucosinolate degradation" EXACT [] +is_a: GO:0019762 ! glucosinolate catabolic process +is_a: GO:0042343 ! indole glucosinolate metabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process + +[Term] +id: GO:0042349 +name: guiding stereospecific synthesis activity +namespace: molecular_function +def: "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma] +synonym: "dirigent protein" NARROW [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0042350 +name: GDP-L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl] +synonym: "GDP-L-fucose anabolism" EXACT [] +synonym: "GDP-L-fucose biosynthesis" EXACT [] +synonym: "GDP-L-fucose formation" EXACT [] +synonym: "GDP-L-fucose synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046368 ! GDP-L-fucose metabolic process + +[Term] +id: GO:0042351 +name: 'de novo' GDP-L-fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750] +synonym: "'de novo' GDP-L-fucose anabolism" EXACT [] +synonym: "'de novo' GDP-L-fucose biosynthesis" EXACT [] +synonym: "'de novo' GDP-L-fucose formation" EXACT [] +synonym: "'de novo' GDP-L-fucose synthesis" EXACT [] +synonym: "GDP-L-fucose biosynthesis, de novo pathway" EXACT [] +synonym: "GDP-L-fucose biosynthetic process, de novo pathway" EXACT [] +xref: MetaCyc:PWY-66 +is_a: GO:0042350 ! GDP-L-fucose biosynthetic process + +[Term] +id: GO:0042352 +name: GDP-L-fucose salvage +namespace: biological_process +def: "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma] +synonym: "GDP-L-fucose biosynthesis, salvage pathway" EXACT [] +synonym: "GDP-L-fucose biosynthetic process, salvage pathway" EXACT [] +xref: MetaCyc:PWY-6 +is_a: GO:0042350 ! GDP-L-fucose biosynthetic process +is_a: GO:0043173 ! nucleotide salvage + +[Term] +id: GO:0042353 +name: fucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl] +synonym: "fucose anabolism" EXACT [] +synonym: "fucose biosynthesis" EXACT [] +synonym: "fucose formation" EXACT [] +synonym: "fucose synthesis" EXACT [] +is_a: GO:0006004 ! fucose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0042354 +name: L-fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732] +synonym: "L-fucose metabolism" EXACT [] +is_a: GO:0006004 ! fucose metabolic process + +[Term] +id: GO:0042355 +name: L-fucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl] +synonym: "L-fucose breakdown" EXACT [] +synonym: "L-fucose catabolism" EXACT [] +synonym: "L-fucose degradation" EXACT [] +is_a: GO:0019317 ! fucose catabolic process +is_a: GO:0042354 ! L-fucose metabolic process + +[Term] +id: GO:0042356 +name: GDP-4-dehydro-D-rhamnose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187] +synonym: "GDP-4-keto-6-deoxy-D-mannose reductase activity" RELATED [EC:1.1.1.187] +synonym: "GDP-4-keto-D-rhamnose reductase activity" RELATED [EC:1.1.1.187] +synonym: "GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity" RELATED [EC:1.1.1.187] +synonym: "guanosine diphosphate-4-keto-D-rhamnose reductase activity" RELATED [EC:1.1.1.187] +xref: EC:1.1.1.187 +xref: MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0042357 +name: thiamine diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] +synonym: "thiamin diphosphate metabolic process" EXACT [] +synonym: "thiamin diphosphate metabolism" EXACT [] +synonym: "thiamin pyrophosphate metabolic process" EXACT [] +synonym: "thiamin pyrophosphate metabolism" EXACT [] +synonym: "thiamine diphosphate metabolism" EXACT [] +synonym: "thiamine pyrophosphate metabolic process" EXACT [] +synonym: "thiamine pyrophosphate metabolism" EXACT [] +synonym: "TPP metabolic process" EXACT [] +synonym: "TPP metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0042723 ! thiamine-containing compound metabolic process + +[Term] +id: GO:0042358 +name: thiamine diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] +synonym: "thiamin diphosphate breakdown" EXACT [] +synonym: "thiamin diphosphate catabolic process" EXACT [] +synonym: "thiamin diphosphate catabolism" EXACT [] +synonym: "thiamin diphosphate degradation" EXACT [] +synonym: "thiamin pyrophosphate catabolic process" EXACT [] +synonym: "thiamin pyrophosphate catabolism" EXACT [] +synonym: "thiamine diphosphate catabolism" EXACT [] +synonym: "thiamine pyrophosphate catabolic process" EXACT [] +synonym: "thiamine pyrophosphate catabolism" EXACT [] +synonym: "TPP catabolic process" EXACT [] +synonym: "TPP catabolism" EXACT [] +is_a: GO:0042357 ! thiamine diphosphate metabolic process +is_a: GO:0042725 ! thiamine-containing compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0042359 +name: vitamin D metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] +synonym: "calciferol metabolic process" NARROW [] +synonym: "calciferol metabolism" NARROW [] +synonym: "cholecalciferol metabolic process" NARROW [] +synonym: "cholecalciferol metabolism" NARROW [] +synonym: "ergocalciferol metabolic process" NARROW [] +synonym: "ergocalciferol metabolism" NARROW [] +synonym: "vitamin D metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042360 +name: vitamin E metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732] +synonym: "alpha-tocopherol metabolic process" NARROW [] +synonym: "alpha-tocopherol metabolism" NARROW [] +synonym: "tocopherol metabolic process" EXACT [] +synonym: "tocopherol metabolism" EXACT [] +synonym: "vitamin E metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042361 +name: menaquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "menaquinone breakdown" EXACT [] +synonym: "menaquinone catabolism" EXACT [] +synonym: "menaquinone degradation" EXACT [] +synonym: "menatetrenone catabolic process" EXACT [] +synonym: "menatetrenone catabolism" EXACT [] +synonym: "multiprenylmenaquinone catabolic process" EXACT [] +synonym: "multiprenylmenaquinone catabolism" EXACT [] +synonym: "vitamin K2 catabolic process" EXACT [] +synonym: "vitamin K2 catabolism" EXACT [] +is_a: GO:0009233 ! menaquinone metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:0042362 +name: fat-soluble vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] +synonym: "fat-soluble vitamin anabolism" EXACT [] +synonym: "fat-soluble vitamin biosynthesis" EXACT [] +synonym: "fat-soluble vitamin formation" EXACT [] +synonym: "fat-soluble vitamin synthesis" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0009110 ! vitamin biosynthetic process + +[Term] +id: GO:0042363 +name: fat-soluble vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] +synonym: "fat-soluble vitamin breakdown" EXACT [] +synonym: "fat-soluble vitamin catabolism" EXACT [] +synonym: "fat-soluble vitamin degradation" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:0009111 ! vitamin catabolic process + +[Term] +id: GO:0042364 +name: water-soluble vitamin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl] +synonym: "water-soluble vitamin anabolism" EXACT [] +synonym: "water-soluble vitamin biosynthesis" EXACT [] +synonym: "water-soluble vitamin formation" EXACT [] +synonym: "water-soluble vitamin synthesis" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009110 ! vitamin biosynthetic process + +[Term] +id: GO:0042365 +name: water-soluble vitamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "water-soluble vitamin breakdown" EXACT [] +synonym: "water-soluble vitamin catabolism" EXACT [] +synonym: "water-soluble vitamin degradation" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0009111 ! vitamin catabolic process + +[Term] +id: GO:0042366 +name: cobalamin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] +synonym: "cobalamin breakdown" EXACT [] +synonym: "cobalamin catabolism" EXACT [] +synonym: "cobalamin degradation" EXACT [] +synonym: "vitamin B12 catabolic process" EXACT [] +synonym: "vitamin B12 catabolism" EXACT [] +is_a: GO:0009235 ! cobalamin metabolic process +is_a: GO:0033015 ! tetrapyrrole catabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process + +[Term] +id: GO:0042367 +name: biotin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] +synonym: "biotin breakdown" EXACT [] +synonym: "biotin catabolism" EXACT [] +synonym: "biotin degradation" EXACT [] +synonym: "vitamin B7 catabolic process" EXACT [] +synonym: "vitamin B7 catabolism" EXACT [] +synonym: "vitamin H catabolic process" EXACT [] +synonym: "vitamin H catabolism" EXACT [] +is_a: GO:0006768 ! biotin metabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0043605 ! cellular amide catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042368 +name: vitamin D biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] +synonym: "calciferol biosynthesis" NARROW [] +synonym: "calciferol biosynthetic process" NARROW [] +synonym: "cholecalciferol biosynthesis" NARROW [] +synonym: "cholecalciferol biosynthetic process" NARROW [] +synonym: "ergocalciferol biosynthesis" NARROW [] +synonym: "ergocalciferol biosynthetic process" NARROW [] +synonym: "vitamin D anabolism" EXACT [] +synonym: "vitamin D biosynthesis" EXACT [] +synonym: "vitamin D formation" EXACT [] +synonym: "vitamin D synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042359 ! vitamin D metabolic process +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0042369 +name: vitamin D catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:mah, ISBN:0471331309] +synonym: "calciferol catabolic process" NARROW [] +synonym: "calciferol catabolism" NARROW [] +synonym: "cholecalciferol biosynthesis" NARROW [] +synonym: "cholecalciferol biosynthetic process" NARROW [] +synonym: "ergocalciferol biosynthesis" NARROW [] +synonym: "ergocalciferol biosynthetic process" NARROW [] +synonym: "vitamin D breakdown" EXACT [] +synonym: "vitamin D catabolism" EXACT [] +synonym: "vitamin D degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0042359 ! vitamin D metabolic process +is_a: GO:0042363 ! fat-soluble vitamin catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0042370 +name: thiamine diphosphate dephosphorylation +namespace: biological_process +def: "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732] +synonym: "thiamin diphosphate dephosphorylation" EXACT [] +synonym: "TPP dephosphorylation" EXACT [] +is_a: GO:0042357 ! thiamine diphosphate metabolic process + +[Term] +id: GO:0042371 +name: vitamin K biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "naphthoquinone metabolic process" BROAD [] +synonym: "naphthoquinone metabolism" BROAD [] +synonym: "vitamin K anabolism" EXACT [] +synonym: "vitamin K biosynthesis" EXACT [] +synonym: "vitamin K formation" EXACT [] +synonym: "vitamin K synthesis" EXACT [] +is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process +is_a: GO:0042373 ! vitamin K metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:0042372 +name: phylloquinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "phylloquinone anabolism" EXACT [] +synonym: "phylloquinone biosynthesis" EXACT [] +synonym: "phylloquinone formation" EXACT [] +synonym: "phylloquinone synthesis" EXACT [] +synonym: "phytomenadione biosynthesis" EXACT [] +synonym: "phytomenadione biosynthetic process" EXACT [] +synonym: "phytonadione biosynthesis" EXACT [] +synonym: "phytonadione biosynthetic process" EXACT [] +synonym: "phytylmenaquinone biosynthesis" EXACT [] +synonym: "phytylmenaquinone biosynthetic process" EXACT [] +synonym: "vitamin K1 biosynthesis" EXACT [] +synonym: "vitamin K1 biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5027 +is_a: GO:0042371 ! vitamin K biosynthetic process +is_a: GO:0042374 ! phylloquinone metabolic process + +[Term] +id: GO:0042373 +name: vitamin K metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "naphthoquinone metabolic process" BROAD [] +synonym: "naphthoquinone metabolism" BROAD [] +synonym: "vitamin K metabolism" EXACT [] +is_a: GO:0006775 ! fat-soluble vitamin metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:0042374 +name: phylloquinone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "phylloquinone metabolism" EXACT [] +synonym: "phytomenadione metabolic process" EXACT [] +synonym: "phytomenadione metabolism" EXACT [] +synonym: "phytonadione metabolic process" EXACT [] +synonym: "phytonadione metabolism" EXACT [] +synonym: "phytylmenaquinone metabolic process" EXACT [] +synonym: "phytylmenaquinone metabolism" EXACT [] +synonym: "vitamin K1 metabolic process" EXACT [] +synonym: "vitamin K1 metabolism" EXACT [] +is_a: GO:0042373 ! vitamin K metabolic process + +[Term] +id: GO:0042376 +name: phylloquinone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "phylloquinone breakdown" EXACT [] +synonym: "phylloquinone catabolism" EXACT [] +synonym: "phylloquinone degradation" EXACT [] +synonym: "phytomenadione catabolic process" EXACT [] +synonym: "phytomenadione catabolism" EXACT [] +synonym: "phytonadione catabolic process" EXACT [] +synonym: "phytonadione catabolism" EXACT [] +synonym: "phytylmenaquinone catabolic process" EXACT [] +synonym: "phytylmenaquinone catabolism" EXACT [] +synonym: "vitamin K1 catabolic process" EXACT [] +synonym: "vitamin K1 catabolism" EXACT [] +is_a: GO:0042374 ! phylloquinone metabolic process +is_a: GO:0042377 ! vitamin K catabolic process + +[Term] +id: GO:0042377 +name: vitamin K catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] +synonym: "naphthoquinone catabolic process" EXACT [] +synonym: "naphthoquinone catabolism" EXACT [] +synonym: "vitamin K breakdown" EXACT [] +synonym: "vitamin K catabolism" EXACT [] +synonym: "vitamin K degradation" EXACT [] +is_a: GO:0042363 ! fat-soluble vitamin catabolic process +is_a: GO:0042373 ! vitamin K metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:0042379 +name: chemokine receptor binding +namespace: molecular_function +def: "Binding to a chemokine receptor." [GOC:ai] +synonym: "chemokine receptor ligand" NARROW [] +is_a: GO:0001664 ! G protein-coupled receptor binding +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0042380 +name: hydroxymethylbutenyl pyrophosphate reductase activity +namespace: molecular_function +def: "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js, PMID:11818558] +synonym: "(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming)" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0042381 +name: hemolymph coagulation +namespace: biological_process +def: "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949] +synonym: "hemolymph clotting" EXACT [] +is_a: GO:0006959 ! humoral immune response +is_a: GO:0007599 ! hemostasis +is_a: GO:0045087 ! innate immune response +is_a: GO:0050817 ! coagulation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0042382 +name: paraspeckles +namespace: cellular_component +def: "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299] +xref: Wikipedia:Paraspeckle +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0042383 +name: sarcolemma +namespace: cellular_component +def: "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732] +xref: Wikipedia:Sarcolemma +is_a: GO:0005886 ! plasma membrane + +[Term] +id: GO:0042385 +name: myosin III complex +namespace: cellular_component +def: "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0042386 +name: hemocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723] +synonym: "arthropod blood cell differentiation" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0042387 +name: plasmatocyte differentiation +namespace: biological_process +def: "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791] +is_a: GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0042388 +name: gibberellic acid mediated signaling pathway, G-alpha-dependent +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] +synonym: "gibberellic acid mediated signalling, G-alpha-dependent" EXACT [] +is_a: GO:0009740 ! gibberellic acid mediated signaling pathway + +[Term] +id: GO:0042389 +name: omega-3 fatty acid desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0042390 +name: gibberellic acid mediated signaling pathway, G-alpha-independent +namespace: biological_process +def: "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362] +synonym: "gibberellic acid mediated signalling, G-alpha-independent" EXACT [] +is_a: GO:0009740 ! gibberellic acid mediated signaling pathway + +[Term] +id: GO:0042391 +name: regulation of membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0042392 +name: sphingosine-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:8663293] +synonym: "sphingosine-1-phosphate phosphohydrolase activity" EXACT [] +synonym: "SPP phosphatase activity" EXACT [] +synonym: "SPPase activity" EXACT [] +xref: MetaCyc:RXN3DJ-25 +xref: Reactome:R-HSA-428690 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [extracellular]" +xref: Reactome:R-HSA-428696 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]" +xref: Reactome:R-HSA-428701 "sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - SGPP]" +xref: RHEA:27518 +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0042393 +name: histone binding +namespace: molecular_function +def: "Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_yeast +synonym: "histone-specific chaperone activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042394 +name: obsolete ecdysis, protein-based cuticle +namespace: biological_process +def: "OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] +comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. +synonym: "ecdysis, protein-based cuticle" EXACT [] +is_obsolete: true +consider: GO:0018990 +consider: GO:0042395 + +[Term] +id: GO:0042395 +name: ecdysis, collagen and cuticulin-based cuticle +namespace: biological_process +def: "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu] +is_a: GO:0022404 ! molting cycle process +relationship: part_of GO:0018996 ! molting cycle, collagen and cuticulin-based cuticle + +[Term] +id: GO:0042396 +name: phosphagen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] +synonym: "phosphagen anabolism" EXACT [] +synonym: "phosphagen biosynthesis" EXACT [] +synonym: "phosphagen formation" EXACT [] +synonym: "phosphagen synthesis" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0042397 +name: phosphagen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] +synonym: "phosphagen breakdown" EXACT [] +synonym: "phosphagen catabolism" EXACT [] +synonym: "phosphagen degradation" EXACT [] +is_a: GO:0006599 ! phosphagen metabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0042398 +name: cellular modified amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] +synonym: "amino acid derivative biosynthetic process" EXACT [] +synonym: "cellular amino acid derivative anabolism" EXACT [] +synonym: "cellular amino acid derivative biosynthesis" EXACT [] +synonym: "cellular amino acid derivative biosynthetic process" EXACT [] +synonym: "cellular amino acid derivative formation" EXACT [] +synonym: "cellular amino acid derivative synthesis" EXACT [] +synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah] +synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah] +synonym: "cellular modified amino acid formation" EXACT [GOC:mah] +synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042399 +name: ectoine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +synonym: "ectoine metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0042400 +name: ectoine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] +synonym: "ectoine breakdown" EXACT [] +synonym: "ectoine catabolism" EXACT [] +synonym: "ectoine degradation" EXACT [] +is_a: GO:0042399 ! ectoine metabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042401 +name: cellular biogenic amine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] +synonym: "biogenic amine anabolism" EXACT [] +synonym: "biogenic amine biosynthesis" EXACT [] +synonym: "biogenic amine formation" EXACT [] +synonym: "biogenic amine synthesis" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0009309 ! amine biosynthetic process + +[Term] +id: GO:0042402 +name: cellular biogenic amine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732] +synonym: "biogenic amine breakdown" EXACT [] +synonym: "biogenic amine catabolism" EXACT [] +synonym: "biogenic amine degradation" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:0009310 ! amine catabolic process + +[Term] +id: GO:0042403 +name: thyroid hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] +synonym: "thyroid hormone metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042404 +name: thyroid hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732] +synonym: "thyroid hormone breakdown" EXACT [] +synonym: "thyroid hormone catabolism" EXACT [] +synonym: "thyroid hormone degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0042403 ! thyroid hormone metabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0042405 +name: nuclear inclusion body +namespace: cellular_component +def: "An intranuclear focus at which aggregated proteins have been sequestered." [GOC:jl] +is_a: GO:0016234 ! inclusion body +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0042406 +name: extrinsic component of endoplasmic reticulum membrane +namespace: cellular_component +def: "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] +synonym: "extrinsic to endoplasmic reticulum membrane" NARROW [] +synonym: "extrinsic to ER membrane" EXACT [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0042407 +name: cristae formation +namespace: biological_process +def: "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] +is_a: GO:0007007 ! inner mitochondrial membrane organization + +[Term] +id: GO:0042408 +name: obsolete myrcene/(E)-beta-ocimene synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382] +comment: This term was made obsolete because it represents two activities. +synonym: "myrcene/(E)-beta-ocimene synthase activity" EXACT [] +synonym: "myrcene/ocimene synthase activity" EXACT [] +xref: EC:4.6.-.- +is_obsolete: true + +[Term] +id: GO:0042409 +name: caffeoyl-CoA O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104] +synonym: "caffeoyl coenzyme A methyltransferase activity" EXACT [] +synonym: "caffeoyl-CoA 3-O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity" RELATED [EC:2.1.1.104] +synonym: "trans-caffeoyl-CoA 3-O-methyltransferase activity" RELATED [EC:2.1.1.104] +xref: EC:2.1.1.104 +xref: MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN +xref: RHEA:16925 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0042410 +name: 6-carboxyhexanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA." [EC:6.2.1.14, RHEA:14781] +synonym: "6-carboxyhexanoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.14] +synonym: "6-carboxyhexanoyl-CoA synthetase activity" RELATED [EC:6.2.1.14] +synonym: "pimeloyl-CoA synthetase activity" RELATED [EC:6.2.1.14] +synonym: "pimelyl-CoA synthetase activity" RELATED [EC:6.2.1.14] +xref: EC:6.2.1.14 +xref: KEGG_REACTION:R03209 +xref: MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN +xref: RHEA:14781 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0042412 +name: taurine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] +synonym: "taurine anabolism" EXACT [] +synonym: "taurine biosynthesis" EXACT [] +synonym: "taurine formation" EXACT [] +synonym: "taurine synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019530 ! taurine metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046305 ! alkanesulfonate biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042413 +name: carnitine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] +synonym: "carnitine breakdown" EXACT [] +synonym: "carnitine catabolism" EXACT [] +synonym: "carnitine degradation" EXACT [] +synonym: "vitamin Bt catabolic process" EXACT [] +synonym: "vitamin Bt catabolism" EXACT [] +is_a: GO:0006579 ! amino-acid betaine catabolic process +is_a: GO:0009437 ! carnitine metabolic process + +[Term] +id: GO:0042414 +name: epinephrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] +synonym: "adrenaline metabolic process" EXACT [] +synonym: "adrenaline metabolism" EXACT [] +synonym: "epinephrine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042415 +name: norepinephrine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] +synonym: "levarterenol metabolic process" EXACT [] +synonym: "levarterenol metabolism" EXACT [] +synonym: "noradrenaline metabolic process" EXACT [] +synonym: "noradrenaline metabolism" EXACT [] +synonym: "norepinephrine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042416 +name: dopamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] +synonym: "dopamine anabolism" EXACT [] +synonym: "dopamine biosynthesis" EXACT [] +synonym: "dopamine formation" EXACT [] +synonym: "dopamine synthesis" EXACT [] +is_a: GO:0042417 ! dopamine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042417 +name: dopamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] +synonym: "dopamine metabolism" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0042418 +name: epinephrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] +synonym: "adrenaline biosynthesis" EXACT [] +synonym: "adrenaline biosynthetic process" EXACT [] +synonym: "epinephrine anabolism" EXACT [] +synonym: "epinephrine biosynthesis" EXACT [] +synonym: "epinephrine formation" EXACT [] +synonym: "epinephrine synthesis" EXACT [] +is_a: GO:0042414 ! epinephrine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042419 +name: epinephrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732] +synonym: "adrenaline catabolic process" EXACT [] +synonym: "adrenaline catabolism" EXACT [] +synonym: "epinephrine breakdown" EXACT [] +synonym: "epinephrine catabolism" EXACT [] +synonym: "epinephrine degradation" EXACT [] +is_a: GO:0042414 ! epinephrine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042420 +name: dopamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732] +synonym: "dopamine breakdown" EXACT [] +synonym: "dopamine catabolism" EXACT [] +synonym: "dopamine degradation" EXACT [] +is_a: GO:0042417 ! dopamine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042421 +name: norepinephrine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] +synonym: "levarterenol biosynthesis" EXACT [] +synonym: "levarterenol biosynthetic process" EXACT [] +synonym: "noradrenaline biosynthesis" EXACT [] +synonym: "noradrenaline biosynthetic process" EXACT [] +synonym: "norepinephrine anabolism" EXACT [] +synonym: "norepinephrine biosynthesis" EXACT [] +synonym: "norepinephrine formation" EXACT [] +synonym: "norepinephrine synthesis" EXACT [] +is_a: GO:0042415 ! norepinephrine metabolic process +is_a: GO:0042423 ! catecholamine biosynthetic process + +[Term] +id: GO:0042422 +name: norepinephrine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732] +synonym: "levarterenol catabolic process" EXACT [] +synonym: "levarterenol catabolism" EXACT [] +synonym: "noradrenaline catabolic process" EXACT [] +synonym: "noradrenaline catabolism" EXACT [] +synonym: "norepinephrine breakdown" EXACT [] +synonym: "norepinephrine catabolism" EXACT [] +synonym: "norepinephrine degradation" EXACT [] +xref: Wikipedia:Norepinephrine#Degradation +is_a: GO:0042415 ! norepinephrine metabolic process +is_a: GO:0042424 ! catecholamine catabolic process + +[Term] +id: GO:0042423 +name: catecholamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] +synonym: "catecholamine anabolism" EXACT [] +synonym: "catecholamine biosynthesis" EXACT [] +synonym: "catecholamine formation" EXACT [] +synonym: "catecholamine synthesis" EXACT [] +xref: Wikipedia:Catecholamines +is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process + +[Term] +id: GO:0042424 +name: catecholamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] +synonym: "catecholamine breakdown" EXACT [] +synonym: "catecholamine catabolism" EXACT [] +synonym: "catecholamine degradation" EXACT [] +is_a: GO:0006584 ! catecholamine metabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process + +[Term] +id: GO:0042425 +name: choline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +synonym: "choline anabolism" EXACT [] +synonym: "choline biosynthesis" EXACT [] +synonym: "choline formation" EXACT [] +synonym: "choline synthesis" EXACT [] +xref: MetaCyc:PWY-4762 +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process + +[Term] +id: GO:0042426 +name: choline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] +synonym: "choline breakdown" EXACT [] +synonym: "choline catabolism" EXACT [] +synonym: "choline degradation" EXACT [] +is_a: GO:0019695 ! choline metabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process + +[Term] +id: GO:0042427 +name: serotonin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] +synonym: "serotonin anabolism" EXACT [] +synonym: "serotonin biosynthesis" EXACT [] +synonym: "serotonin formation" EXACT [] +synonym: "serotonin synthesis" EXACT [] +xref: Wikipedia:Serotonin +is_a: GO:0042428 ! serotonin metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:0042428 +name: serotonin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] +synonym: "serotonin metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0097164 ! ammonium ion metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0042429 +name: serotonin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] +synonym: "serotonin breakdown" EXACT [] +synonym: "serotonin catabolism" EXACT [] +synonym: "serotonin degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042428 ! serotonin metabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:1901161 ! primary amino compound catabolic process + +[Term] +id: GO:0042430 +name: indole-containing compound metabolic process +namespace: biological_process +alt_id: GO:0042434 +def: "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl, GOC:mah] +synonym: "indole and derivative metabolic process" EXACT [] +synonym: "indole and derivative metabolism" EXACT [] +synonym: "indole derivative metabolic process" NARROW [] +synonym: "indole derivative metabolism" NARROW [] +synonym: "indole-containing compound metabolism" EXACT [] +synonym: "ketole metabolic process" EXACT [] +synonym: "ketole metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0042431 +name: indole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] +synonym: "indole metabolism" EXACT [] +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:0042432 +name: indole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] +synonym: "indole anabolism" EXACT [] +synonym: "indole biosynthesis" EXACT [] +synonym: "indole formation" EXACT [] +synonym: "indole synthesis" EXACT [] +is_a: GO:0042431 ! indole metabolic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process + +[Term] +id: GO:0042433 +name: indole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [GOC:jl] +synonym: "indole breakdown" EXACT [] +synonym: "indole catabolism" EXACT [] +synonym: "indole degradation" EXACT [] +is_a: GO:0042431 ! indole metabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process + +[Term] +id: GO:0042435 +name: indole-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] +synonym: "indole derivative biosynthesis" EXACT [] +synonym: "indole derivative biosynthetic process" EXACT [] +synonym: "indole-containing compound anabolism" EXACT [] +synonym: "indole-containing compound biosynthesis" EXACT [] +synonym: "indole-containing compound formation" EXACT [] +synonym: "indole-containing compound synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042436 +name: indole-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [GOC:jl] +synonym: "indole derivative catabolic process" EXACT [] +synonym: "indole derivative catabolism" EXACT [] +synonym: "indole-containing compound breakdown" EXACT [] +synonym: "indole-containing compound catabolism" EXACT [] +synonym: "indole-containing compound degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042437 +name: indoleacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl] +synonym: "IAA catabolic process" EXACT [] +synonym: "indole acetic acid catabolic process" EXACT [] +synonym: "indole acetic acid catabolism" EXACT [] +synonym: "indoleacetic acid breakdown" EXACT [] +synonym: "indoleacetic acid catabolism" EXACT [] +synonym: "indoleacetic acid degradation" EXACT [] +is_a: GO:0009683 ! indoleacetic acid metabolic process +is_a: GO:0009852 ! auxin catabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0042438 +name: melanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:curators] +synonym: "melanin anabolism" EXACT [] +synonym: "melanin biosynthesis" EXACT [] +synonym: "melanin formation" EXACT [] +synonym: "melanin synthesis" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0042439 +name: ethanolamine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [GOC:mah] +synonym: "ethanolamine and derivative metabolic process" EXACT [] +synonym: "ethanolamine and derivative metabolism" EXACT [] +synonym: "ethanolamine-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006576 ! cellular biogenic amine metabolic process + +[Term] +id: GO:0042440 +name: pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732] +subset: goslim_drosophila +subset: goslim_pir +synonym: "pigment metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0042441 +name: eye pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment metabolism" EXACT [] +is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation +relationship: part_of GO:0048069 ! eye pigmentation + +[Term] +id: GO:0042442 +name: melatonin catabolic process +namespace: biological_process +alt_id: GO:0042449 +def: "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl] +synonym: "melatonin breakdown" EXACT [] +synonym: "melatonin catabolism" EXACT [] +synonym: "melatonin degradation" EXACT [] +is_a: GO:0030186 ! melatonin metabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:0042447 ! hormone catabolic process + +[Term] +id: GO:0042443 +name: phenylethylamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine metabolism" EXACT [] +is_a: GO:0006576 ! cellular biogenic amine metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0042444 +name: phenylethylamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] +synonym: "phenylethylamine anabolism" EXACT [] +synonym: "phenylethylamine biosynthesis" EXACT [] +synonym: "phenylethylamine formation" EXACT [] +synonym: "phenylethylamine synthesis" EXACT [] +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:0042443 ! phenylethylamine metabolic process +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:0042445 +name: hormone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] +subset: goslim_pir +synonym: "hormone metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process +is_a: GO:0010817 ! regulation of hormone levels + +[Term] +id: GO:0042446 +name: hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] +synonym: "hormone anabolism" EXACT [] +synonym: "hormone biosynthesis" EXACT [] +synonym: "hormone formation" EXACT [] +synonym: "hormone synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042447 +name: hormone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:jl] +synonym: "hormone breakdown" EXACT [] +synonym: "hormone catabolism" EXACT [] +synonym: "hormone degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0042445 ! hormone metabolic process + +[Term] +id: GO:0042448 +name: progesterone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] +synonym: "progesterone metabolism" EXACT [] +is_a: GO:0008207 ! C21-steroid hormone metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0042450 +name: arginine biosynthetic process via ornithine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl] +synonym: "arginine anabolism via ornithine" EXACT [] +synonym: "arginine formation via ornithine" EXACT [] +synonym: "arginine synthesis via ornithine" EXACT [] +is_a: GO:0006526 ! arginine biosynthetic process +is_a: GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0042451 +name: purine nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] +synonym: "purine nucleoside anabolism" EXACT [] +synonym: "purine nucleoside biosynthesis" EXACT [] +synonym: "purine nucleoside formation" EXACT [] +synonym: "purine nucleoside synthesis" EXACT [] +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0042278 ! purine nucleoside metabolic process +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0042452 +name: deoxyguanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] +synonym: "deoxyguanosine anabolism" EXACT [] +synonym: "deoxyguanosine biosynthesis" EXACT [] +synonym: "deoxyguanosine formation" EXACT [] +synonym: "deoxyguanosine synthesis" EXACT [] +is_a: GO:0042453 ! deoxyguanosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0042453 +name: deoxyguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl] +synonym: "deoxyguanosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0042454 +name: ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] +synonym: "ribonucleoside breakdown" EXACT [] +synonym: "ribonucleoside catabolism" EXACT [] +synonym: "ribonucleoside degradation" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process + +[Term] +id: GO:0042455 +name: ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl] +synonym: "ribonucleoside anabolism" EXACT [] +synonym: "ribonucleoside biosynthesis" EXACT [] +synonym: "ribonucleoside formation" EXACT [] +synonym: "ribonucleoside synthesis" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process + +[Term] +id: GO:0042457 +name: ethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845] +synonym: "ethene catabolic process" EXACT [] +synonym: "ethene catabolism" EXACT [] +synonym: "ethylene breakdown" EXACT [] +synonym: "ethylene catabolism" EXACT [] +synonym: "ethylene degradation" EXACT [] +is_a: GO:0009692 ! ethylene metabolic process +is_a: GO:0043451 ! alkene catabolic process + +[Term] +id: GO:0042458 +name: nopaline catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators] +synonym: "nopaline breakdown to proline" EXACT [] +synonym: "nopaline degradation to proline" EXACT [] +xref: MetaCyc:NOPALINEDEG-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0019468 ! nopaline catabolic process + +[Term] +id: GO:0042459 +name: octopine catabolic process to proline +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators] +synonym: "octopine breakdown to proline" EXACT [] +synonym: "octopine degradation to proline" EXACT [] +xref: MetaCyc:OCTOPINEDEG-PWY +is_a: GO:0006560 ! proline metabolic process +is_a: GO:0019469 ! octopine catabolic process + +[Term] +id: GO:0042461 +name: photoreceptor cell development +namespace: biological_process +alt_id: GO:0046531 +def: "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators] +synonym: "photoreceptor morphogenesis" EXACT [] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0042462 +name: eye photoreceptor cell development +namespace: biological_process +def: "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981] +is_a: GO:0042461 ! photoreceptor cell development +relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation + +[Term] +id: GO:0042463 +name: ocellus photoreceptor cell development +namespace: biological_process +alt_id: GO:0001749 +def: "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766] +synonym: "non-eye photoreceptor development" BROAD [] +is_a: GO:0042461 ! photoreceptor cell development +relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation + +[Term] +id: GO:0042464 +name: dosage compensation by hypoactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mr, PMID:11102361, PMID:20622855, Wikipedia:XY_sex-determination_system] +is_a: GO:0007549 ! dosage compensation + +[Term] +id: GO:0042465 +name: kinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023] +xref: Wikipedia:Kinesis +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0042466 +name: chemokinesis +namespace: biological_process +def: "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411] +xref: Wikipedia:Chemokinesis +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042467 +name: orthokinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088] +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042468 +name: klinokinesis +namespace: biological_process +def: "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068] +is_a: GO:0042465 ! kinesis + +[Term] +id: GO:0042469 +name: versicolorin reductase activity +namespace: molecular_function +def: "Catalysis of the reduction of versicolorin A to sterigmatocystin." [PMID:1339261] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0042470 +name: melanosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301] +xref: Wikipedia:Melanosome +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0042471 +name: ear morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] +synonym: "hearing organ morphogenesis" EXACT [] +is_a: GO:0048562 ! embryonic organ morphogenesis +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0043583 ! ear development + +[Term] +id: GO:0042472 +name: inner ear morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0042473 +name: outer ear morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis + +[Term] +id: GO:0042474 +name: middle ear morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042471 ! ear morphogenesis + +[Term] +id: GO:0042475 +name: odontogenesis of dentin-containing tooth +namespace: biological_process +def: "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794] +comment: Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See Wikipedia:Placoid_scale#Placoid_scales. +synonym: "odontogenesis of dentine-containing teeth" EXACT [] +synonym: "odontogenesis of dentine-containing tooth" EXACT [GOC:mah] +synonym: "odontogeny" BROAD [] +synonym: "odontosis" BROAD [] +synonym: "tooth development" BROAD [] +is_a: GO:0042476 ! odontogenesis + +[Term] +id: GO:0042476 +name: odontogenesis +namespace: biological_process +alt_id: GO:0042477 +def: "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah] +synonym: "odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "odontogeny" EXACT [] +synonym: "odontosis" EXACT [] +synonym: "tooth development" RELATED [] +synonym: "tooth morphogenesis" EXACT [] +xref: Wikipedia:Odontogenesis +is_a: GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0042478 +name: regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "regulation of eye photoreceptor development" EXACT [] +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042479 +name: positive regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "activation of eye photoreceptor cell development" NARROW [] +synonym: "positive regulation of eye photoreceptor development" EXACT [] +synonym: "stimulation of eye photoreceptor cell development" NARROW [] +synonym: "up regulation of eye photoreceptor cell development" EXACT [] +synonym: "up-regulation of eye photoreceptor cell development" EXACT [] +synonym: "upregulation of eye photoreceptor cell development" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +relationship: positively_regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042480 +name: negative regulation of eye photoreceptor cell development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl] +synonym: "down regulation of eye photoreceptor cell development" EXACT [] +synonym: "down-regulation of eye photoreceptor cell development" EXACT [] +synonym: "downregulation of eye photoreceptor cell development" EXACT [] +synonym: "inhibition of eye photoreceptor cell development" NARROW [] +synonym: "negative regulation of eye photoreceptor development" EXACT [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +relationship: negatively_regulates GO:0042462 ! eye photoreceptor cell development + +[Term] +id: GO:0042481 +name: regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042484 +def: "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "regulation of tooth development" EXACT [] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042482 +name: positive regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042485 +def: "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "activation of odontogenesis" NARROW [] +synonym: "positive regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "positive regulation of tooth development" EXACT [] +synonym: "stimulation of odontogenesis" NARROW [] +synonym: "up regulation of odontogenesis" EXACT [] +synonym: "up-regulation of odontogenesis" EXACT [] +synonym: "upregulation of odontogenesis" EXACT [] +is_a: GO:0042481 ! regulation of odontogenesis +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +relationship: positively_regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042483 +name: negative regulation of odontogenesis +namespace: biological_process +alt_id: GO:0042486 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl] +synonym: "down regulation of odontogenesis" EXACT [] +synonym: "down-regulation of odontogenesis" EXACT [] +synonym: "downregulation of odontogenesis" EXACT [] +synonym: "inhibition of odontogenesis" NARROW [] +synonym: "negative regulation of odontogenesis of calcareous or chitinous tooth" NARROW [] +synonym: "negative regulation of tooth development" EXACT [] +is_a: GO:0042481 ! regulation of odontogenesis +is_a: GO:0110111 ! negative regulation of animal organ morphogenesis +relationship: negatively_regulates GO:0042476 ! odontogenesis + +[Term] +id: GO:0042487 +name: regulation of odontogenesis of dentin-containing tooth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794] +synonym: "regulation of odontogenesis of dentine-containing teeth" EXACT [] +synonym: "regulation of odontogenesis of dentine-containing tooth" EXACT [GOC:mah] +is_a: GO:0042481 ! regulation of odontogenesis +relationship: regulates GO:0042475 ! odontogenesis of dentin-containing tooth + +[Term] +id: GO:0042488 +name: positive regulation of odontogenesis of dentin-containing tooth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, PMID:15355794] +synonym: "activation of odontogenesis" BROAD [] +synonym: "positive regulation of odontogenesis of dentine-containing teeth" EXACT [] +synonym: "positive regulation of odontogenesis of dentine-containing tooth" RELATED [] +synonym: "stimulation of odontogenesis" BROAD [] +synonym: "up regulation of odontogenesis" BROAD [] +synonym: "up-regulation of odontogenesis" BROAD [] +synonym: "upregulation of odontogenesis" BROAD [] +is_a: GO:0042482 ! positive regulation of odontogenesis +is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth +relationship: positively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth + +[Term] +id: GO:0042489 +name: negative regulation of odontogenesis of dentin-containing tooth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794] +synonym: "down regulation of odontogenesis" BROAD [] +synonym: "down-regulation of odontogenesis" BROAD [] +synonym: "downregulation of odontogenesis" BROAD [] +synonym: "inhibition of odontogenesis" BROAD [] +synonym: "negative regulation of odontogenesis" BROAD [] +synonym: "negative regulation of odontogenesis of dentine-containing teeth" EXACT [] +synonym: "negative regulation of odontogenesis of dentine-containing tooth" RELATED [] +is_a: GO:0042483 ! negative regulation of odontogenesis +is_a: GO:0042487 ! regulation of odontogenesis of dentin-containing tooth +relationship: negatively_regulates GO:0042475 ! odontogenesis of dentin-containing tooth + +[Term] +id: GO:0042490 +name: mechanoreceptor differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0042491 +name: inner ear auditory receptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl] +comment: Note that this term refers to the mechanosensory hair cells of the inner ear. +synonym: "auditory hair cell differentiation" EXACT [] +synonym: "auditory receptor cell differentiation" RELATED [] +is_a: GO:0035315 ! hair cell differentiation +is_a: GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0042492 +name: gamma-delta T cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "gamma-delta T cell development" RELATED [GOC:add] +synonym: "gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "gamma-delta T-cell differentiation" EXACT [] +synonym: "gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0042494 +name: detection of bacterial lipoprotein +namespace: biological_process +def: "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222] +synonym: "detection of BLP" RELATED [] +synonym: "detection of Lpp" RELATED [] +synonym: "perception of bacterial lipoprotein" RELATED [] +synonym: "perception of BLP" RELATED [] +synonym: "perception of Lpp" RELATED [] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0032493 ! response to bacterial lipoprotein +relationship: part_of GO:0016045 ! detection of bacterium + +[Term] +id: GO:0042495 +name: detection of triacyl bacterial lipopeptide +namespace: biological_process +def: "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "detection of triacylated bacterial lipoprotein" EXACT [GOC:add] +synonym: "perception of triacylated bacterial lipopeptide" RELATED [GOC:add] +synonym: "perception of triacylated bacterial lipoprotein" RELATED [] +is_a: GO:0070340 ! detection of bacterial lipopeptide +is_a: GO:0071725 ! response to triacyl bacterial lipopeptide + +[Term] +id: GO:0042496 +name: detection of diacyl bacterial lipopeptide +namespace: biological_process +def: "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "detection of diacylated bacterial lipoprotein" EXACT [GOC:add] +synonym: "perception of diacylated bacterial lipopeptide" RELATED [GOC:add] +synonym: "perception of diacylated bacterial lipoprotein" RELATED [] +is_a: GO:0070340 ! detection of bacterial lipopeptide +is_a: GO:0071724 ! response to diacyl bacterial lipopeptide + +[Term] +id: GO:0042497 +name: triacyl lipopeptide binding +namespace: molecular_function +def: "Binding to a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "bacterial triacyl lipopeptide binding" NARROW [GOC:add] +synonym: "bacterial triacyl lipoprotein binding" RELATED [GOC:add] +synonym: "triacylated lipopeptide binding" EXACT [] +is_a: GO:0071723 ! lipopeptide binding + +[Term] +id: GO:0042498 +name: diacyl lipopeptide binding +namespace: molecular_function +def: "Binding to a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "bacterial diacyl lipopeptide binding" NARROW [GOC:add] +synonym: "bacterial diacyl lipoprotein binding" RELATED [GOC:add] +synonym: "diacylated lipopeptide binding" EXACT [] +is_a: GO:0071723 ! lipopeptide binding + +[Term] +id: GO:0042499 +name: obsolete signal peptide peptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416] +comment: This term was made obsolete because it represents a gene product. +synonym: "signal peptide peptidase activity" EXACT [] +synonym: "SPP" EXACT [] +is_obsolete: true +replaced_by: GO:0042500 + +[Term] +id: GO:0042500 +name: aspartic endopeptidase activity, intramembrane cleaving +namespace: molecular_function +def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732] +comment: Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. +xref: EC:3.4.23.- +xref: Reactome:R-HSA-8863101 "SPPL2a/b cleaves TNF(1-76)" +is_a: GO:0004190 ! aspartic-type endopeptidase activity + +[Term] +id: GO:0042501 +name: serine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:0033136 +def: "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] +synonym: "serine phosphorylation of STAT3 protein" NARROW [] +is_a: GO:0018105 ! peptidyl-serine phosphorylation +relationship: part_of GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0042509 +name: regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:0042510 +alt_id: GO:0042513 +alt_id: GO:0042516 +alt_id: GO:0042519 +alt_id: GO:0042522 +alt_id: GO:0042525 +alt_id: GO:0042528 +def: "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +synonym: "regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042531 +name: positive regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:0042511 +alt_id: GO:0042515 +alt_id: GO:0042517 +alt_id: GO:0042520 +alt_id: GO:0042523 +alt_id: GO:0042526 +alt_id: GO:0042529 +def: "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +synonym: "activation of tyrosine phosphorylation of STAT protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "activation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "positive regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of STAT protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "stimulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "up regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "up regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "up-regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "up-regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "upregulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "upregulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042532 +name: negative regulation of tyrosine phosphorylation of STAT protein +namespace: biological_process +alt_id: GO:0042512 +alt_id: GO:0042514 +alt_id: GO:0042518 +alt_id: GO:0042521 +alt_id: GO:0042524 +alt_id: GO:0042527 +alt_id: GO:0042530 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647] +synonym: "down regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "down regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "down-regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of STAT protein" EXACT [] +synonym: "downregulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of STAT protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of Stat7 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat1 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat2 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat3 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat4 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat5 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat6 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of Stat7 protein" NARROW [] +is_a: GO:0042509 ! regulation of tyrosine phosphorylation of STAT protein +is_a: GO:0046426 ! negative regulation of receptor signaling pathway via JAK-STAT +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0007260 ! tyrosine phosphorylation of STAT protein + +[Term] +id: GO:0042537 +name: benzene-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [GOC:jl] +synonym: "benzene and derivative metabolic process" EXACT [] +synonym: "benzene and derivative metabolism" EXACT [] +synonym: "benzene-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0042538 +name: hyperosmotic salinity response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +synonym: "response to hyperosmotic salt stress" EXACT [] +synonym: "salt tolerance" RELATED [] +is_a: GO:0006972 ! hyperosmotic response +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0042539 +name: hypotonic salinity response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] +synonym: "response to hypotonic salt stress" EXACT [] +is_a: GO:0006971 ! hypotonic response +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0042540 +name: hemoglobin catabolic process +namespace: biological_process +alt_id: GO:0020029 +def: "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [GOC:jl, GOC:mb] +comment: Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process. +synonym: "haemoglobin catabolic process" EXACT [] +synonym: "haemoglobin catabolism" EXACT [] +synonym: "haemoglobin hydrolysis" NARROW [] +synonym: "hemoglobin breakdown" EXACT [] +synonym: "hemoglobin catabolism" EXACT [] +synonym: "hemoglobin degradation" EXACT [] +synonym: "hemoglobin hydrolysis" NARROW [] +is_a: GO:0020027 ! hemoglobin metabolic process +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0042541 +name: hemoglobin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:jl] +synonym: "haemoglobin biosynthesis" EXACT [] +synonym: "haemoglobin biosynthetic process" EXACT [] +synonym: "hemoglobin anabolism" EXACT [] +synonym: "hemoglobin biosynthesis" EXACT [] +synonym: "hemoglobin formation" EXACT [] +synonym: "hemoglobin synthesis" EXACT [] +is_a: GO:0020027 ! hemoglobin metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042542 +name: response to hydrogen peroxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0042543 +name: protein N-linked glycosylation via arginine +namespace: biological_process +def: "The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine." [RESID:AA0327] +synonym: "protein amino acid N-linked glycosylation via arginine" EXACT [GOC:bf] +xref: RESID:AA0327 +is_a: GO:0006487 ! protein N-linked glycosylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0042544 +name: melibiose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732] +synonym: "melibiose anabolism" EXACT [] +synonym: "melibiose biosynthesis" EXACT [] +synonym: "melibiose formation" EXACT [] +synonym: "melibiose synthesis" EXACT [] +is_a: GO:0005994 ! melibiose metabolic process +is_a: GO:0046351 ! disaccharide biosynthetic process + +[Term] +id: GO:0042545 +name: cell wall modification +namespace: biological_process +def: "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl] +is_a: GO:0071555 ! cell wall organization + +[Term] +id: GO:0042546 +name: cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732] +synonym: "cell wall assembly" NARROW [] +is_a: GO:0044085 ! cellular component biogenesis +is_a: GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0042547 +name: cell wall modification involved in multidimensional cell growth +namespace: biological_process +def: "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb] +synonym: "cell wall modification during cell expansion" EXACT [] +synonym: "cell wall modification during multidimensional cell growth" RELATED [GOC:dph, GOC:tb] +is_a: GO:0042545 ! cell wall modification +relationship: part_of GO:0009825 ! multidimensional cell growth + +[Term] +id: GO:0042548 +name: regulation of photosynthesis, light reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0042549 +name: photosystem II stabilization +namespace: biological_process +def: "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction + +[Term] +id: GO:0042550 +name: photosystem I stabilization +namespace: biological_process +def: "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction + +[Term] +id: GO:0042551 +name: neuron maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0042552 +name: myelination +namespace: biological_process +def: "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah] +synonym: "myelinogenesis" RELATED [GOC:cjm, HP:0003429] +xref: Wikipedia:Myelin +is_a: GO:0008366 ! axon ensheathment + +[Term] +id: GO:0042554 +name: superoxide anion generation +namespace: biological_process +def: "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750] +synonym: "superoxide release" EXACT [GOC:hjd, GOC:mah] +is_a: GO:0006801 ! superoxide metabolic process + +[Term] +id: GO:0042555 +name: MCM complex +namespace: cellular_component +def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] +synonym: "mini-chromosome maintenance complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0042556 +name: eukaryotic elongation factor-2 kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] +synonym: "eEF-2 kinase regulator" EXACT [] +is_a: GO:0019887 ! protein kinase regulator activity + +[Term] +id: GO:0042557 +name: eukaryotic elongation factor-2 kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175] +synonym: "eEF-2 kinase activator" EXACT [] +is_a: GO:0042556 ! eukaryotic elongation factor-2 kinase regulator activity +is_a: GO:0043539 ! protein serine/threonine kinase activator activity + +[Term] +id: GO:0042558 +name: pteridine-containing compound metabolic process +namespace: biological_process +alt_id: GO:0019721 +def: "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] +synonym: "pteridine and derivative metabolic process" EXACT [] +synonym: "pteridine and derivative metabolism" EXACT [] +synonym: "pteridine-containing compound metabolism" EXACT [] +synonym: "pterin metabolic process" NARROW [] +synonym: "pterin metabolism" NARROW [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0042559 +name: pteridine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] +subset: goslim_pombe +synonym: "pteridine and derivative biosynthesis" EXACT [] +synonym: "pteridine and derivative biosynthetic process" EXACT [] +synonym: "pteridine-containing compound anabolism" EXACT [] +synonym: "pteridine-containing compound biosynthesis" EXACT [] +synonym: "pteridine-containing compound formation" EXACT [] +synonym: "pteridine-containing compound synthesis" EXACT [] +synonym: "pterin biosynthesis" NARROW [] +synonym: "pterin biosynthetic process" NARROW [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042560 +name: pteridine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732] +synonym: "pteridine and derivative catabolic process" EXACT [] +synonym: "pteridine and derivative catabolism" EXACT [] +synonym: "pteridine-containing compound breakdown" EXACT [] +synonym: "pteridine-containing compound catabolism" EXACT [] +synonym: "pteridine-containing compound degradation" EXACT [] +synonym: "pterin catabolic process" NARROW [] +synonym: "pterin catabolism" NARROW [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042561 +name: alpha-amyrin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960] +xref: MetaCyc:RXN-8434 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0042562 +name: hormone binding +namespace: molecular_function +def: "Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor." [GOC:jl] +subset: goslim_chembl +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0042563 +name: obsolete importin alpha-subunit nuclear export complex +namespace: cellular_component +def: "OBSOLETE. A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to transport the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134] +comment: The reason for obsoletion is that these terms include the substrate of the reaction. +is_obsolete: true + +[Term] +id: GO:0042564 +name: NLS-dependent protein nuclear import complex +namespace: cellular_component +def: "A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134, Wikipedia:Importin] +is_a: GO:0031074 ! nucleocytoplasmic transport complex + +[Term] +id: GO:0042565 +name: RNA nuclear export complex +namespace: cellular_component +def: "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123] +is_a: GO:0031074 ! nucleocytoplasmic transport complex + +[Term] +id: GO:0042566 +name: hydrogenosome +namespace: cellular_component +def: "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569] +subset: goslim_pir +xref: Wikipedia:Hydrogenosome +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0042567 +name: insulin-like growth factor ternary complex +namespace: cellular_component +def: "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] +synonym: "IGF ternary complex" EXACT [] +is_a: GO:0016942 ! insulin-like growth factor binding protein complex + +[Term] +id: GO:0042568 +name: insulin-like growth factor binary complex +namespace: cellular_component +def: "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079] +synonym: "IGF binary complex" EXACT [] +is_a: GO:0016942 ! insulin-like growth factor binding protein complex + +[Term] +id: GO:0042571 +name: immunoglobulin complex, circulating +namespace: cellular_component +def: "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149] +comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "antibody" EXACT [GOC:add] +xref: Wikipedia:Antibody +is_a: GO:0019814 ! immunoglobulin complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0042572 +name: retinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] +synonym: "retinol metabolism" EXACT [] +synonym: "vitamin A1 alcohol metabolic process" EXACT [] +synonym: "vitamin A1 alcohol metabolism" EXACT [] +synonym: "vitamin A1 metabolic process" EXACT [] +synonym: "vitamin A1 metabolism" EXACT [] +xref: Wikipedia:Retinol +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0042573 +name: retinoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "retinoic acid metabolism" EXACT [] +synonym: "vitamin A1 acid metabolic process" EXACT [] +synonym: "vitamin A1 acid metabolism" EXACT [] +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0042574 +name: retinal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [ISBN:0198506732] +synonym: "retinal metabolism" EXACT [] +synonym: "retinaldehyde metabolic process" EXACT [] +synonym: "retinaldehyde metabolism" EXACT [] +is_a: GO:0001523 ! retinoid metabolic process +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0042575 +name: DNA polymerase complex +namespace: cellular_component +def: "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093] +subset: goslim_metagenomics +subset: goslim_pir +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0042576 +name: obsolete aspartyl aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21] +comment: This term was made obsolete because it represents a gene product. +synonym: "aspartyl aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0042577 +name: lipid phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate." [GOC:jl] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0042578 +name: phosphoric ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0042579 +name: microbody +namespace: cellular_component +def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] +subset: goslim_pir +xref: Wikipedia:Microbody +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0042580 +name: mannosome +namespace: cellular_component +def: "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531] +is_a: GO:0005777 ! peroxisome + +[Term] +id: GO:0042581 +name: specific granule +namespace: cellular_component +def: "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544, PMID:7334549] +synonym: "secondary granule" EXACT [] +xref: Wikipedia:Specific_granule +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042582 +name: azurophil granule +namespace: cellular_component +def: "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, PMID:17152095] +synonym: "primary granule" EXACT [] +is_a: GO:0005766 ! primary lysosome +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042583 +name: chromaffin granule +namespace: cellular_component +def: "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042584 +name: chromaffin granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042583 ! chromaffin granule + +[Term] +id: GO:0042585 +name: germinal vesicle +namespace: cellular_component +def: "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837] +synonym: "primary oocyte nucleus" EXACT [] +is_a: GO:0001674 ! female germ cell nucleus + +[Term] +id: GO:0042586 +name: peptide deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl] +synonym: "formyl-L-methionyl peptide amidohydrolase activity" RELATED [EC:3.5.1.88] +synonym: "PDF activity" RELATED [EC:3.5.1.88] +synonym: "polypeptide deformylase activity" RELATED [EC:3.5.1.88] +xref: EC:3.5.1.88 +xref: MetaCyc:3.5.1.88-RXN +xref: RHEA:24420 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0042587 +name: glycogen granule +namespace: cellular_component +def: "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, PMID:12179957] +synonym: "glycogen particle" EXACT [] +xref: NIF_Subcellular:sao1081228141 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0042588 +name: zymogen granule +namespace: cellular_component +def: "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042589 +name: zymogen granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a zymogen granule." [GOC:jl] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042588 ! zymogen granule + +[Term] +id: GO:0042590 +name: antigen processing and presentation of exogenous peptide antigen via MHC class I +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "antigen presentation, exogenous antigen via major histocompatibility complex class I" EXACT [] +synonym: "antigen presentation, exogenous antigen via MHC class I" EXACT [] +synonym: "cross presentation" BROAD [] +synonym: "cross priming" BROAD [] +synonym: "cross-presentation" BROAD [] +synonym: "cross-priming" BROAD [] +synonym: "exogenous peptide antigen processing and presentation via MHC class I" EXACT [] +is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen + +[Term] +id: GO:0042592 +name: homeostatic process +namespace: biological_process +alt_id: GO:0032844 +alt_id: GO:0032845 +alt_id: GO:0032846 +def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_mouse +synonym: "activation of homeostatic process" NARROW [] +synonym: "homeostasis" EXACT [] +synonym: "inhibition of homeostatic process" NARROW [] +synonym: "negative regulation of homeostatic process" RELATED [] +synonym: "positive regulation of homeostatic process" RELATED [] +synonym: "regulation of homeostatic process" RELATED [] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0042593 +name: glucose homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] +is_a: GO:0033500 ! carbohydrate homeostasis + +[Term] +id: GO:0042594 +name: response to starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] +subset: goslim_yeast +is_a: GO:0006950 ! response to stress +is_a: GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0042595 +name: behavioral response to starvation +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators] +synonym: "behavioural response to starvation" EXACT [] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0042596 +name: fear response +namespace: biological_process +alt_id: GO:0001663 +def: "The response of an organism to a perceived external threat." [GOC:go_curators] +synonym: "physiological fear response" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0042597 +name: periplasmic space +namespace: cellular_component +alt_id: GO:0005620 +def: "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "periplasm" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0042598 +name: obsolete vesicular fraction +namespace: cellular_component +def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl] +comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "vesicular fraction" EXACT [] +is_obsolete: true +consider: GO:0031982 + +[Term] +id: GO:0042599 +name: lamellar body +namespace: cellular_component +def: "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, PMID:12243725, Wikipedia:Lamellar_granule] +synonym: "keratinosome" NARROW [] +synonym: "lamellar granule" EXACT [] +synonym: "membrane-coating granule" EXACT [] +synonym: "Odland body" NARROW [] +xref: NIF_Subcellular:sao1379604862 +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042600 +name: egg chorion +namespace: cellular_component +def: "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544] +comment: Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. +subset: goslim_pir +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0042601 +name: endospore-forming forespore +namespace: cellular_component +def: "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029] +is_a: GO:0042763 ! intracellular immature spore + +[Term] +id: GO:0042602 +name: riboflavin reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+." [EC:1.5.1.30] +synonym: "flavin reductase activity" RELATED [EC:1.5.1.30] +synonym: "FMN reductase (NADPH) activity" RELATED [EC:1.5.1.30] +synonym: "NADPH dehydrogenase (riboflavin) activity" RELATED [EC:1.5.1.30] +synonym: "NADPH-dependent FMN reductase activity" RELATED [EC:1.5.1.30] +synonym: "NADPH-FMN reductase activity" RELATED [EC:1.5.1.30] +synonym: "NADPH-riboflavin oxidoreductase activity" EXACT [] +synonym: "NADPH-riboflavin reductase activity" RELATED [EC:1.5.1.30] +synonym: "NADPH-specific FMN reductase activity" RELATED [EC:1.5.1.30] +synonym: "NADPH2 dehydrogenase (riboflavin)" RELATED [EC:1.5.1.30] +synonym: "NADPH2:riboflavin oxidoreductase activity" RELATED [EC:1.5.1.30] +synonym: "NADPH:riboflavin oxidoreductase activity" RELATED [EC:1.5.1.30] +synonym: "reduced-riboflavin:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.30] +synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.5.1.30] +synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.30] +synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.30] +xref: EC:1.5.1.30 +xref: EC:1.5.1.41 +xref: KEGG_REACTION:R05707 +xref: MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN +xref: RHEA:19377 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0042603 +name: capsule +namespace: cellular_component +alt_id: GO:0030113 +alt_id: GO:0042604 +def: "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg] +xref: Wikipedia:Capsule_(microbiology) +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0042605 +name: peptide antigen binding +namespace: molecular_function +alt_id: GO:0042606 +alt_id: GO:0042607 +def: "Binding to an antigen peptide." [GOC:add, GOC:jl, GOC:rv] +comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule. +subset: goslim_chembl +synonym: "endogenous peptide antigen binding" NARROW [] +synonym: "exogenous peptide antigen binding" NARROW [] +is_a: GO:0003823 ! antigen binding +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0042608 +name: T cell receptor binding +namespace: molecular_function +def: "Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl] +synonym: "T lymphocyte receptor binding" EXACT [] +synonym: "T-cell receptor binding" EXACT [] +synonym: "T-lymphocyte receptor binding" EXACT [] +synonym: "TCR binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0042609 +name: CD4 receptor binding +namespace: molecular_function +def: "Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MSH:D015704] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042610 +name: CD8 receptor binding +namespace: molecular_function +def: "Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MSH:D016827] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042611 +name: MHC protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240] +subset: goslim_pir +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0042612 +name: MHC class I protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149] +comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0042613 +name: MHC class II protein complex +namespace: cellular_component +def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678] +is_a: GO:0042611 ! MHC protein complex + +[Term] +id: GO:0042614 +name: CD70 receptor binding +namespace: molecular_function +def: "Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859] +synonym: "CD27 receptor activity" RELATED [] +synonym: "CD27L binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042615 +name: CD154 receptor binding +namespace: molecular_function +def: "Binding to CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859] +synonym: "CD40 receptor activity" RELATED [] +synonym: "CD40L binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042616 +name: paclitaxel metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia." [GOC:jl, GOC:krc] +synonym: "paclitaxel metabolism" EXACT [] +synonym: "taxol metabolic process" NARROW [] +synonym: "taxol metabolism" NARROW [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0042617 +name: paclitaxel biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia." [GOC:jl, GOC:krc] +synonym: "paclitaxel anabolism" EXACT [] +synonym: "paclitaxel biosynthesis" EXACT [] +synonym: "paclitaxel formation" EXACT [] +synonym: "paclitaxel synthesis" EXACT [] +synonym: "taxol biosynthesis" NARROW [] +synonym: "taxol biosynthetic process" NARROW [] +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0042616 ! paclitaxel metabolic process + +[Term] +id: GO:0042618 +name: poly-hydroxybutyrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095] +synonym: "PHB metabolic process" EXACT [] +synonym: "PHB metabolism" EXACT [] +synonym: "poly-hydroxybutyrate metabolism" EXACT [] +is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process + +[Term] +id: GO:0042619 +name: poly-hydroxybutyrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, PMID:18640095] +synonym: "PHB biosynthesis" EXACT [] +synonym: "PHB biosynthetic process" EXACT [] +synonym: "poly-hydroxybutyrate anabolism" EXACT [] +synonym: "poly-hydroxybutyrate biosynthesis" EXACT [] +synonym: "poly-hydroxybutyrate formation" EXACT [] +synonym: "poly-hydroxybutyrate synthesis" EXACT [] +is_a: GO:0042618 ! poly-hydroxybutyrate metabolic process +is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process + +[Term] +id: GO:0042620 +name: poly(3-hydroxyalkanoate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] +subset: goslim_pir +synonym: "PHA metabolic process" BROAD [] +synonym: "PHA metabolism" BROAD [] +synonym: "poly(3-hydroxyalkanoate) metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0042621 +name: poly(3-hydroxyalkanoate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580] +synonym: "PHA biosynthesis" BROAD [] +synonym: "PHA biosynthetic process" BROAD [] +synonym: "poly(3-hydroxyalkanoate) anabolism" EXACT [] +synonym: "poly(3-hydroxyalkanoate) biosynthesis" EXACT [] +synonym: "poly(3-hydroxyalkanoate) formation" EXACT [] +synonym: "poly(3-hydroxyalkanoate) synthesis" EXACT [] +is_a: GO:0042620 ! poly(3-hydroxyalkanoate) metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0042622 +name: photoreceptor outer segment membrane +namespace: cellular_component +def: "The membrane surrounding the outer segment of a vertebrate photoreceptor." [GOC:jl] +is_a: GO:0060170 ! ciliary membrane +relationship: part_of GO:0001750 ! photoreceptor outer segment + +[Term] +id: GO:0042624 +name: obsolete ATPase activity, uncoupled +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [PMID:12912988] +comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. +is_obsolete: true + +[Term] +id: GO:0042625 +name: ATPase-coupled ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +synonym: "ATP-dependent ion transmembrane transporter activity" EXACT [] +synonym: "ATPase activity, coupled to transmembrane movement of ions" EXACT [] +synonym: "ATPase coupled ion transmembrane transporter activity" EXACT [] +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0042626 +name: ATPase-coupled transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015405 +alt_id: GO:0016820 +alt_id: GO:0043492 +def: "Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729] +synonym: "ATP-coupled transmembrane transporter activity" EXACT [] +synonym: "ATP-dependent transmembrane transporter activity" EXACT [] +synonym: "ATPase activity, coupled to movement of substances" BROAD [] +synonym: "ATPase activity, coupled to transmembrane movement of substances" EXACT [] +synonym: "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" NARROW [] +synonym: "P-P-bond-hydrolysis-driven transmembrane transporter activity" BROAD [] +synonym: "P-P-bond-hydrolysis-driven transporter" BROAD [] +xref: Reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region" +xref: Reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" +xref: Reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" +xref: Reactome:R-HSA-9033499 "PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol" +xref: Reactome:R-HSA-9033505 "PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12" +is_a: GO:0015399 ! primary active transmembrane transporter activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0042627 +name: chylomicron +namespace: cellular_component +def: "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, PMID:10580165] +xref: Wikipedia:Chylomicron +is_a: GO:0034358 ! plasma lipoprotein particle + +[Term] +id: GO:0042628 +name: mating plug formation +namespace: biological_process +def: "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, PMID:11267893] +synonym: "copulatory plug biosynthesis" EXACT [] +synonym: "copulatory plug deposition" EXACT [] +synonym: "copulatory plug formation" EXACT [] +synonym: "mating plug deposition" EXACT [] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0042629 +name: mast cell granule +namespace: cellular_component +def: "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0042630 +name: behavioral response to water deprivation +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl] +synonym: "behavioral response to drought" EXACT [] +synonym: "behavioral response to thirst" EXACT [] +synonym: "behavioural response to water deprivation" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0009414 ! response to water deprivation + +[Term] +id: GO:0042631 +name: cellular response to water deprivation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators] +synonym: "cellular response to drought" EXACT [] +is_a: GO:0009414 ! response to water deprivation +is_a: GO:0031668 ! cellular response to extracellular stimulus +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0071462 ! cellular response to water stimulus + +[Term] +id: GO:0042632 +name: cholesterol homeostasis +namespace: biological_process +alt_id: GO:2000188 +alt_id: GO:2000189 +def: "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators] +synonym: "positive regulation of cholesterol homeostasis" RELATED [] +synonym: "regulation of cholesterol homeostasis" RELATED [] +is_a: GO:0055092 ! sterol homeostasis + +[Term] +id: GO:0042633 +name: hair cycle +namespace: biological_process +def: "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507] +is_a: GO:0042303 ! molting cycle + +[Term] +id: GO:0042634 +name: regulation of hair cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042635 +name: positive regulation of hair cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +synonym: "activation of hair cycle" NARROW [] +synonym: "stimulation of hair cycle" NARROW [] +synonym: "up regulation of hair cycle" EXACT [] +synonym: "up-regulation of hair cycle" EXACT [] +synonym: "upregulation of hair cycle" EXACT [] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042636 +name: negative regulation of hair cycle +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507] +synonym: "down regulation of hair cycle" EXACT [] +synonym: "down-regulation of hair cycle" EXACT [] +synonym: "downregulation of hair cycle" EXACT [] +synonym: "inhibition of hair cycle" NARROW [] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0042633 ! hair cycle + +[Term] +id: GO:0042637 +name: catagen +namespace: biological_process +def: "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "hair regression" NARROW [] +is_a: GO:0044851 ! hair cycle phase +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042638 +name: exogen +namespace: biological_process +def: "The shedding phase of the hair cycle." [PMID:12230507] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "hair shedding" NARROW [] +is_a: GO:0044851 ! hair cycle phase +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042639 +name: telogen +namespace: biological_process +def: "The resting phase of hair cycle." [PMID:12230507] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "hair resting phase" NARROW [] +is_a: GO:0044851 ! hair cycle phase + +[Term] +id: GO:0042640 +name: anagen +namespace: biological_process +def: "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "hair growth" RELATED [] +is_a: GO:0044851 ! hair cycle phase +relationship: part_of GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0042641 +name: actomyosin +namespace: cellular_component +def: "Any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +synonym: "actomyosin complex" EXACT [] +synonym: "actomyosin structure" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0042642 +name: actomyosin, myosin complex part +namespace: cellular_component +def: "The myosin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +is_a: GO:0016459 ! myosin complex +relationship: part_of GO:0042641 ! actomyosin + +[Term] +id: GO:0042643 +name: obsolete actomyosin, actin portion +namespace: cellular_component +def: "OBSOLETE. The actin part of any complex of actin, myosin, and accessory proteins." [GOC:go_curators] +comment: This term was obsoleted because it corresponds to a gene product, actin. +is_obsolete: true + +[Term] +id: GO:0042644 +name: chloroplast nucleoid +namespace: cellular_component +def: "The region of a chloroplast to which the DNA is confined." [GOC:jl] +is_a: GO:0042646 ! plastid nucleoid +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0042645 +name: mitochondrial nucleoid +namespace: cellular_component +def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] +is_a: GO:0009295 ! nucleoid +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0042646 +name: plastid nucleoid +namespace: cellular_component +def: "The region of a plastid to which the DNA is confined." [GOC:jl] +is_a: GO:0009295 ! nucleoid +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0009532 ! plastid stroma + +[Term] +id: GO:0042647 +name: proplastid nucleoid +namespace: cellular_component +def: "The region of a proplastid to which the DNA is confined." [GOC:jl] +is_a: GO:0042646 ! plastid nucleoid +relationship: part_of GO:0009571 ! proplastid stroma + +[Term] +id: GO:0042648 +name: chloroplast chromosome +namespace: cellular_component +def: "A circular DNA molecule containing chloroplast encoded genes." [GOC:jl] +is_a: GO:0009508 ! plastid chromosome +relationship: part_of GO:0042644 ! chloroplast nucleoid + +[Term] +id: GO:0042649 +name: prothylakoid +namespace: cellular_component +def: "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175] +is_a: GO:0031976 ! plastid thylakoid +relationship: part_of GO:0009513 ! etioplast + +[Term] +id: GO:0042650 +name: prothylakoid membrane +namespace: cellular_component +def: "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175] +is_a: GO:0055035 ! plastid thylakoid membrane +relationship: part_of GO:0042649 ! prothylakoid + +[Term] +id: GO:0042651 +name: thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of any thylakoid." [GOC:jl, GOC:pr] +is_a: GO:0034357 ! photosynthetic membrane + +[Term] +id: GO:0042652 +name: mitochondrial respiratory chain complex I, peripheral segment +namespace: cellular_component +def: "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] +synonym: "NADH dehydrogenase (ubiquinone) complex, peripheral segment" BROAD [] +synonym: "NADH-Q oxidoreductase complex, peripheral segment" BROAD [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +is_a: GO:0098803 ! respiratory chain complex +relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I + +[Term] +id: GO:0042653 +name: mitochondrial respiratory chain complex I, membrane segment +namespace: cellular_component +def: "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556] +synonym: "NADH-Q oxidoreductase complex, membrane segment" BROAD [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +is_a: GO:0098803 ! respiratory chain complex +relationship: part_of GO:0005747 ! mitochondrial respiratory chain complex I + +[Term] +id: GO:0042654 +name: ecdysis-triggering hormone receptor activity +namespace: molecular_function +def: "Combining with ecdysis-triggering hormone to initiate a change in cell activity." [GOC:ma] +synonym: "ecdysis-triggering hormone binding" NARROW [] +synonym: "ETH receptor" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0042655 +name: obsolete activation of JNKKK activity +namespace: biological_process +def: "OBSOLETE. The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of JUN kinase kinase kinase activity" EXACT [] +synonym: "positive regulation of JUNKKK activity" BROAD [] +is_obsolete: true +consider: GO:0007254 +consider: GO:0043539 + +[Term] +id: GO:0042656 +name: JUN kinase kinase kinase kinase activity +namespace: molecular_function +def: "Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs)." [GOC:bf] +synonym: "JUNKKKK activity" EXACT [] +is_a: GO:0008349 ! MAP kinase kinase kinase kinase activity + +[Term] +id: GO:0042657 +name: MHC class II protein binding, via lateral surface +namespace: molecular_function +def: "Binding to the lateral surface of major histocompatibility complex class II molecules." [GOC:jl] +synonym: "major histocompatibility complex class II protein binding, via lateral surface" EXACT [] +is_a: GO:0042289 ! MHC class II protein binding + +[Term] +id: GO:0042658 +name: MHC class II protein binding, via antigen binding groove +namespace: molecular_function +def: "Binding to the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl] +synonym: "major histocompatibility complex class II protein binding, via antigen binding groove" EXACT [] +is_a: GO:0042289 ! MHC class II protein binding +relationship: part_of GO:0023026 ! MHC class II protein complex binding + +[Term] +id: GO:0042659 +name: regulation of cell fate specification +namespace: biological_process +def: "Any process that mediates the adoption of a specific fate by a cell." [GOC:go_curators] +is_a: GO:0010453 ! regulation of cell fate commitment +relationship: regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0042660 +name: positive regulation of cell fate specification +namespace: biological_process +def: "Any process that activates or enables a cell to adopt a specific fate." [GOC:go_curators] +synonym: "activation of cell fate specification" NARROW [] +synonym: "stimulation of cell fate specification" NARROW [] +synonym: "up regulation of cell fate specification" EXACT [] +synonym: "up-regulation of cell fate specification" EXACT [] +synonym: "upregulation of cell fate specification" EXACT [] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0042659 ! regulation of cell fate specification +relationship: positively_regulates GO:0001708 ! cell fate specification + +[Term] +id: GO:0042661 +name: regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:1905770 ! regulation of mesodermal cell differentiation +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0042662 +name: negative regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators] +synonym: "down regulation of mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of mesodermal cell fate specification" EXACT [] +synonym: "downregulation of mesodermal cell fate specification" EXACT [] +synonym: "inhibition of mesodermal cell fate specification" NARROW [] +synonym: "suppression of mesodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +is_a: GO:1905771 ! negative regulation of mesodermal cell differentiation +relationship: negatively_regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0042663 +name: regulation of endodermal cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an endoderm cell." [GOC:go_curators] +synonym: "regulation of endoderm cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:1903224 ! regulation of endodermal cell differentiation +relationship: regulates GO:0001714 ! endodermal cell fate specification + +[Term] +id: GO:0042664 +name: negative regulation of endodermal cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators] +synonym: "down regulation of endodermal cell fate specification" EXACT [] +synonym: "down-regulation of endodermal cell fate specification" EXACT [] +synonym: "downregulation of endodermal cell fate specification" EXACT [] +synonym: "inhibition of endodermal cell fate specification" NARROW [] +synonym: "negative regulation of endoderm cell fate specification" EXACT [] +synonym: "suppression of endoderm cell fate" EXACT [] +synonym: "suppression of endodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042663 ! regulation of endodermal cell fate specification +is_a: GO:1903225 ! negative regulation of endodermal cell differentiation +relationship: negatively_regulates GO:0001714 ! endodermal cell fate specification + +[Term] +id: GO:0042665 +name: regulation of ectodermal cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an ectoderm cell." [GOC:go_curators] +synonym: "regulation of ectoderm cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +relationship: regulates GO:0001715 ! ectodermal cell fate specification + +[Term] +id: GO:0042666 +name: negative regulation of ectodermal cell fate specification +namespace: biological_process +def: "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators] +synonym: "down regulation of ectodermal cell fate specification" EXACT [] +synonym: "down-regulation of ectodermal cell fate specification" EXACT [] +synonym: "downregulation of ectodermal cell fate specification" EXACT [] +synonym: "inhibition of ectodermal cell fate specification" NARROW [] +synonym: "negative regulation of ectoderm cell fate specification" EXACT [] +synonym: "suppression of ectoderm cell fate" EXACT [] +synonym: "suppression of ectodermal cell fate" EXACT [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042665 ! regulation of ectodermal cell fate specification +relationship: negatively_regulates GO:0001715 ! ectodermal cell fate specification + +[Term] +id: GO:0042667 +name: auditory receptor cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +synonym: "auditory hair cell fate specification" EXACT [] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0009912 ! auditory receptor cell fate commitment + +[Term] +id: GO:0042668 +name: auditory receptor cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +synonym: "auditory hair cell fate determination" EXACT [] +is_a: GO:0048664 ! neuron fate determination +relationship: part_of GO:0009912 ! auditory receptor cell fate commitment + +[Term] +id: GO:0042669 +name: regulation of inner ear auditory receptor cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators] +synonym: "regulation of auditory hair cell fate specification" EXACT [] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation +relationship: regulates GO:0042667 ! auditory receptor cell fate specification + +[Term] +id: GO:0042670 +name: retinal cone cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators] +is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0042671 +name: retinal cone cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] +is_a: GO:0043703 ! photoreceptor cell fate determination +relationship: part_of GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0042672 +name: retinal cone cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] +is_a: GO:0043704 ! photoreceptor cell fate specification +relationship: part_of GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0042673 +name: regulation of retinal cone cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into a retinal cone cell." [GOC:go_curators] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0060222 ! regulation of retinal cone cell fate commitment +relationship: regulates GO:0042672 ! retinal cone cell fate specification + +[Term] +id: GO:0042675 +name: compound eye cone cell differentiation +namespace: biological_process +alt_id: GO:0042674 +def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0042676 +name: compound eye cone cell fate commitment +namespace: biological_process +alt_id: GO:0007466 +def: "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0042675 ! compound eye cone cell differentiation + +[Term] +id: GO:0042679 +name: compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0042678 +def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0042676 ! compound eye cone cell fate commitment + +[Term] +id: GO:0042680 +name: compound eye cone cell fate determination +namespace: biological_process +alt_id: GO:0042677 +def: "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0042676 ! compound eye cone cell fate commitment + +[Term] +id: GO:0042682 +name: regulation of compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0042681 +def: "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu] +is_a: GO:0042659 ! regulation of cell fate specification +relationship: regulates GO:0042679 ! compound eye cone cell fate specification + +[Term] +id: GO:0042683 +name: negative regulation of compound eye cone cell fate specification +namespace: biological_process +alt_id: GO:0010000 +def: "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu] +synonym: "down regulation of cone cell fate specification" BROAD [] +synonym: "down-regulation of cone cell fate specification" BROAD [] +synonym: "downregulation of cone cell fate specification" BROAD [] +synonym: "inhibition of cone cell fate specification" BROAD [] +synonym: "suppression of cone cell fate" BROAD [] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0042682 ! regulation of compound eye cone cell fate specification +relationship: negatively_regulates GO:0042679 ! compound eye cone cell fate specification + +[Term] +id: GO:0042684 +name: cardioblast cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0042685 +name: cardioblast cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +is_a: GO:0060912 ! cardiac cell fate specification +relationship: part_of GO:0042684 ! cardioblast cell fate commitment + +[Term] +id: GO:0042686 +name: regulation of cardioblast cell fate specification +namespace: biological_process +def: "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] +is_a: GO:0051890 ! regulation of cardioblast differentiation +is_a: GO:2000043 ! regulation of cardiac cell fate specification +relationship: regulates GO:0042685 ! cardioblast cell fate specification + +[Term] +id: GO:0042688 +name: crystal cell differentiation +namespace: biological_process +def: "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm] +is_a: GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0042689 +name: regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042690 +name: negative regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +synonym: "down regulation of crystal cell differentiation" EXACT [] +synonym: "down-regulation of crystal cell differentiation" EXACT [] +synonym: "downregulation of crystal cell differentiation" EXACT [] +synonym: "inhibition of crystal cell differentiation" NARROW [] +is_a: GO:0042689 ! regulation of crystal cell differentiation +is_a: GO:0045611 ! negative regulation of hemocyte differentiation +relationship: negatively_regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042691 +name: positive regulation of crystal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators] +synonym: "activation of crystal cell differentiation" NARROW [] +synonym: "stimulation of crystal cell differentiation" NARROW [] +synonym: "up regulation of crystal cell differentiation" EXACT [] +synonym: "up-regulation of crystal cell differentiation" EXACT [] +synonym: "upregulation of crystal cell differentiation" EXACT [] +is_a: GO:0042689 ! regulation of crystal cell differentiation +is_a: GO:0045612 ! positive regulation of hemocyte differentiation +relationship: positively_regulates GO:0042688 ! crystal cell differentiation + +[Term] +id: GO:0042692 +name: muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators] +synonym: "myogenesis" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0061061 ! muscle structure development + +[Term] +id: GO:0042693 +name: muscle cell fate commitment +namespace: biological_process +def: "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0042694 +name: muscle cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0042693 ! muscle cell fate commitment + +[Term] +id: GO:0042695 +name: thelarche +namespace: biological_process +def: "The beginning of development of the breasts in the female." [GOC:curators, PMID:19117864] +xref: Wikipedia:Thelarche +is_a: GO:0046543 ! development of secondary female sexual characteristics +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0042696 +name: menarche +namespace: biological_process +def: "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Menarche +is_a: GO:0022601 ! menstrual cycle phase + +[Term] +id: GO:0042697 +name: menopause +namespace: biological_process +def: "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Menopause +is_a: GO:0022601 ! menstrual cycle phase +relationship: part_of GO:0010259 ! multicellular organism aging + +[Term] +id: GO:0042698 +name: ovulation cycle +namespace: biological_process +def: "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544] +is_a: GO:0048511 ! rhythmic process +is_a: GO:0048609 ! multicellular organismal reproductive process + +[Term] +id: GO:0042699 +name: follicle-stimulating hormone signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by follicle-stimulating hormone." [GOC:dph] +synonym: "follicle stimulating hormone signaling pathway" EXACT [] +synonym: "follicle stimulating hormone signalling pathway" EXACT [] +synonym: "follicle-stimulating hormone signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022602 ! ovulation cycle process +relationship: part_of GO:0001541 ! ovarian follicle development + +[Term] +id: GO:0042700 +name: luteinizing hormone signaling pathway +namespace: biological_process +def: "The series of molecular signals mediated by luteinizing hormone." [GOC:dph] +synonym: "luteinizing hormone signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0042701 +name: progesterone secretion +namespace: biological_process +def: "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0035929 ! steroid hormone secretion +relationship: part_of GO:0001553 ! luteinization + +[Term] +id: GO:0042702 +name: uterine wall growth +namespace: biological_process +def: "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:0040007 ! growth +relationship: part_of GO:0001553 ! luteinization + +[Term] +id: GO:0042703 +name: menstruation +namespace: biological_process +def: "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Menstruation +is_a: GO:0022601 ! menstrual cycle phase + +[Term] +id: GO:0042704 +name: uterine wall breakdown +namespace: biological_process +def: "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph] +is_a: GO:0022602 ! ovulation cycle process + +[Term] +id: GO:0042705 +name: ocellus photoreceptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators] +is_a: GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0042706 +name: eye photoreceptor cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0046552 ! photoreceptor cell fate commitment +relationship: part_of GO:0001754 ! eye photoreceptor cell differentiation + +[Term] +id: GO:0042707 +name: ocellus photoreceptor cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0046552 ! photoreceptor cell fate commitment +relationship: part_of GO:0042705 ! ocellus photoreceptor cell differentiation + +[Term] +id: GO:0042708 +name: obsolete elastase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of elastin." [ISBN:0198506732] +comment: This term was made obsolete because it represents a gene product. +synonym: "elastase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004175 + +[Term] +id: GO:0042709 +name: succinate-CoA ligase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [GOC:jl, PMID:10671455] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0042710 +name: biofilm formation +namespace: biological_process +def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229] +subset: gocheck_do_not_annotate +subset: gocheck_do_not_manually_annotate +subset: goslim_candida +subset: goslim_pir +is_a: GO:0098630 ! aggregation of unicellular organisms + +[Term] +id: GO:0042711 +name: maternal behavior +namespace: biological_process +def: "Female behaviors associated with the care and rearing of offspring." [GOC:curators] +synonym: "maternal behaviour" EXACT [] +is_a: GO:0060746 ! parental behavior + +[Term] +id: GO:0042712 +name: paternal behavior +namespace: biological_process +def: "Male behaviors associated with the care and rearing offspring." [GOC:go_curators] +synonym: "paternal behaviour" EXACT [] +is_a: GO:0060746 ! parental behavior + +[Term] +id: GO:0042713 +name: sperm ejaculation +namespace: biological_process +def: "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0042714 +name: dosage compensation complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007549 ! dosage compensation + +[Term] +id: GO:0042715 +name: dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493] +synonym: "dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome" RELATED [GOC:dph, GOC:tb] +is_a: GO:0042714 ! dosage compensation complex assembly +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0042464 ! dosage compensation by hypoactivation of X chromosome + +[Term] +id: GO:0042716 +name: plasma membrane-derived chromatophore +namespace: cellular_component +def: "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431] +comment: Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. +synonym: "chromatophore vesicle" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0042717 +name: plasma membrane-derived chromatophore membrane +namespace: cellular_component +def: "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431] +is_a: GO:0034357 ! photosynthetic membrane +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0042718 +name: yolk granule +namespace: cellular_component +def: "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, PMID:18046696, PMID:6337890] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060417 ! yolk + +[Term] +id: GO:0042719 +name: mitochondrial intermembrane space protein transporter complex +namespace: cellular_component +def: "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629] +synonym: "Tim9-Tim10 complex" NARROW [] +is_a: GO:0098798 ! mitochondrial protein-containing complex +is_a: GO:1990351 ! transporter complex +relationship: part_of GO:0005758 ! mitochondrial intermembrane space + +[Term] +id: GO:0042720 +name: mitochondrial inner membrane peptidase complex +namespace: cellular_component +def: "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769] +synonym: "IMP" NARROW [] +synonym: "mitochondrion inner membrane peptidase complex" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0042721 +name: TIM22 mitochondrial import inner membrane insertion complex +namespace: cellular_component +def: "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12." [PMID:12191765, PMID:27554484] +synonym: "mitochondrial inner membrane protein insertion complex" EXACT [] +synonym: "mitochondrial protein translocase complex" BROAD [] +synonym: "Tim22 complex" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:0042722 +name: alpha-beta T cell activation by superantigen +namespace: biological_process +def: "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl] +synonym: "alpha-beta T lymphocyte activation by superantigen" EXACT [] +synonym: "alpha-beta T-cell activation by superantigen" EXACT [] +synonym: "alpha-beta T-lymphocyte activation by superantigen" EXACT [] +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0042723 +name: thiamine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [GOC:jl] +synonym: "thiamin and derivative metabolic process" EXACT [] +synonym: "thiamin and derivative metabolism" EXACT [] +synonym: "thiamin-containing compound metabolic process" EXACT [] +synonym: "thiamine and derivative metabolic process" EXACT [] +synonym: "thiamine and derivative metabolism" EXACT [] +synonym: "thiamine-containing compound metabolism" EXACT [] +synonym: "vitamin B1 and derivative metabolic process" EXACT [] +synonym: "vitamin B1 and derivative metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:0042724 +name: thiamine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [GOC:jl] +synonym: "thiamin and derivative biosynthesis" EXACT [] +synonym: "thiamin and derivative biosynthetic process" EXACT [] +synonym: "thiamin-containing compound biosynthetic process" EXACT [] +synonym: "thiamine and derivative biosynthesis" EXACT [] +synonym: "thiamine and derivative biosynthetic process" EXACT [] +synonym: "thiamine-containing compound anabolism" EXACT [] +synonym: "thiamine-containing compound biosynthesis" EXACT [] +synonym: "thiamine-containing compound formation" EXACT [] +synonym: "thiamine-containing compound synthesis" EXACT [] +synonym: "vitamin B1 and derivative biosynthesis" EXACT [] +synonym: "vitamin B1 and derivative biosynthetic process" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042723 ! thiamine-containing compound metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process + +[Term] +id: GO:0042725 +name: thiamine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [GOC:jl] +synonym: "thiamin and derivative catabolic process" EXACT [] +synonym: "thiamin and derivative catabolism" EXACT [] +synonym: "thiamin-containing compound catabolic process" EXACT [] +synonym: "thiamine and derivative catabolic process" EXACT [] +synonym: "thiamine and derivative catabolism" EXACT [] +synonym: "thiamine-containing compound breakdown" EXACT [] +synonym: "thiamine-containing compound catabolism" EXACT [] +synonym: "thiamine-containing compound degradation" EXACT [] +synonym: "vitamin B1 and derivative catabolic process" EXACT [] +synonym: "vitamin B1 and derivative catabolism" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042723 ! thiamine-containing compound metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0072529 ! pyrimidine-containing compound catabolic process + +[Term] +id: GO:0042726 +name: flavin-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] +synonym: "flavin-containing compound metabolism" EXACT [] +synonym: "riboflavin and derivative metabolic process" RELATED [] +synonym: "riboflavin and derivative metabolism" RELATED [] +synonym: "vitamin B2 and derivative metabolic process" RELATED [] +synonym: "vitamin B2 and derivative metabolism" RELATED [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0042727 +name: flavin-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] +synonym: "flavin-containing compound anabolism" EXACT [] +synonym: "flavin-containing compound biosynthesis" EXACT [] +synonym: "flavin-containing compound formation" EXACT [] +synonym: "flavin-containing compound synthesis" EXACT [] +synonym: "riboflavin and derivative biosynthesis" RELATED [] +synonym: "riboflavin and derivative biosynthetic process" RELATED [] +synonym: "vitamin B2 and derivative biosynthesis" RELATED [] +synonym: "vitamin B2 and derivative biosynthetic process" RELATED [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042726 ! flavin-containing compound metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042728 +name: flavin-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [GOC:jl, GOC:mah] +synonym: "flavin-containing compound catabolic process breakdown" EXACT [] +synonym: "flavin-containing compound catabolic process degradation" EXACT [] +synonym: "flavin-containing compound catabolism" EXACT [] +synonym: "riboflavin and derivative catabolic process" RELATED [] +synonym: "riboflavin and derivative catabolism" RELATED [] +synonym: "vitamin B2 and derivative catabolic process" RELATED [] +synonym: "vitamin B2 and derivative catabolism" RELATED [] +is_a: GO:0042726 ! flavin-containing compound metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042729 +name: DASH complex +namespace: cellular_component +alt_id: GO:0043925 +alt_id: GO:0043926 +def: "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:vw, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796] +comment: Note that this complex is conserved in fungi but has not been observed in metazoans. +synonym: "condensed nuclear chromosome kinetochore-associated DASH complex" EXACT [] +synonym: "Dam1 complex" EXACT [] +synonym: "DDD complex" EXACT [] +synonym: "Duo1p-Dam1p-Dad1p complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000940 ! outer kinetochore + +[Term] +id: GO:0042730 +name: fibrinolysis +namespace: biological_process +def: "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." [GOC:jl, PMID:15842654] +xref: Wikipedia:Fibrinolysis +is_a: GO:0030195 ! negative regulation of blood coagulation + +[Term] +id: GO:0042731 +name: PH domain binding +namespace: molecular_function +def: "Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0042732 +name: D-xylose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] +synonym: "D-xylose metabolism" EXACT [] +is_a: GO:0019321 ! pentose metabolic process + +[Term] +id: GO:0042733 +name: embryonic digit morphogenesis +namespace: biological_process +def: "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0030326 ! embryonic limb morphogenesis + +[Term] +id: GO:0042734 +name: presynaptic membrane +namespace: cellular_component +def: "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194] +subset: goslim_synapse +synonym: "pre-synaptic membrane" EXACT [] +synonym: "presynaptic plasma membrane" EXACT [] +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0042735 +name: protein body +namespace: cellular_component +def: "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0042736 +name: NADH kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH." [EC:2.7.1.86, RHEA:12260] +synonym: "ATP:NADH 2'-phosphotransferase activity" RELATED [EC:2.7.1.86] +synonym: "DPNH kinase activity" RELATED [EC:2.7.1.86] +synonym: "reduced diphosphopyridine nucleotide kinase activity" RELATED [EC:2.7.1.86] +synonym: "reduced nicotinamide adenine dinucleotide kinase (phosphorylating)" RELATED [EC:2.7.1.86] +xref: EC:2.7.1.86 +xref: KEGG_REACTION:R00105 +xref: MetaCyc:NADH-KINASE-RXN +xref: RHEA:12260 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0042739 +name: obsolete endogenous drug catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl] +comment: The reason for obsoletion is that there is no evidence that this process exists as a drug is by definition exogenous. +synonym: "endogenous drug breakdown" EXACT [] +synonym: "endogenous drug catabolism" EXACT [] +synonym: "endogenous drug degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0042740 +name: exogenous antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl] +synonym: "exogenous antibiotic breakdown" EXACT [] +synonym: "exogenous antibiotic catabolism" EXACT [] +synonym: "exogenous antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +relationship: part_of GO:0046677 ! response to antibiotic + +[Term] +id: GO:0042741 +name: endogenous antibiotic catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl] +synonym: "endogenous antibiotic breakdown" EXACT [] +synonym: "endogenous antibiotic catabolism" EXACT [] +synonym: "endogenous antibiotic degradation" EXACT [] +is_a: GO:0017001 ! antibiotic catabolic process + +[Term] +id: GO:0042742 +name: defense response to bacterium +namespace: biological_process +alt_id: GO:0009816 +alt_id: GO:0042830 +def: "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl] +synonym: "antibacterial peptide activity" RELATED [] +synonym: "defence response to bacteria" EXACT [] +synonym: "defence response to bacterium" EXACT [] +synonym: "defense response to bacteria" EXACT [] +synonym: "defense response to bacterium, incompatible interaction" NARROW [] +synonym: "resistance response to pathogenic bacteria" NARROW [] +synonym: "resistance response to pathogenic bacterium" NARROW [] +is_a: GO:0009617 ! response to bacterium +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0042743 +name: hydrogen peroxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, PMID:21734470] +synonym: "H2O2 metabolic process" EXACT [GOC:mah] +synonym: "hydrogen peroxide metabolism" EXACT [] +is_a: GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:0042744 +name: hydrogen peroxide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] +synonym: "detoxification of H2O2" RELATED [GOC:vw] +synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw] +synonym: "H2O2 catabolic process" EXACT [GOC:mah] +synonym: "H2O2 scavenging" RELATED [GOC:vw] +synonym: "hydrogen peroxide breakdown" EXACT [] +synonym: "hydrogen peroxide catabolism" EXACT [] +synonym: "hydrogen peroxide degradation" EXACT [] +synonym: "hydrogen peroxide removal" RELATED [] +synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw] +is_a: GO:0042743 ! hydrogen peroxide metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042745 +name: circadian sleep/wake cycle +namespace: biological_process +def: "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com] +is_a: GO:0048512 ! circadian behavior + +[Term] +id: GO:0042746 +name: circadian sleep/wake cycle, wakefulness +namespace: biological_process +def: "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468] +is_a: GO:0022410 ! circadian sleep/wake cycle process + +[Term] +id: GO:0042747 +name: circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172] +is_a: GO:0022410 ! circadian sleep/wake cycle process +relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042748 +name: circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com] +is_a: GO:0022410 ! circadian sleep/wake cycle process +relationship: part_of GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0042749 +name: regulation of circadian sleep/wake cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042745 ! circadian sleep/wake cycle + +[Term] +id: GO:0042750 +name: hibernation +namespace: biological_process +def: "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046] +xref: Wikipedia:Hibernation +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0042751 +name: estivation +namespace: biological_process +def: "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, PMID:12443930, Wikipedia:Estivation] +synonym: "aestivation" EXACT [GOC:pr] +xref: Wikipedia:Estivation +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0042752 +name: regulation of circadian rhythm +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042753 +name: positive regulation of circadian rhythm +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] +synonym: "activation of circadian rhythm" NARROW [] +synonym: "stimulation of circadian rhythm" NARROW [] +synonym: "up regulation of circadian rhythm" EXACT [] +synonym: "up-regulation of circadian rhythm" EXACT [] +synonym: "upregulation of circadian rhythm" EXACT [] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042754 +name: negative regulation of circadian rhythm +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators] +synonym: "down regulation of circadian rhythm" EXACT [] +synonym: "down-regulation of circadian rhythm" EXACT [] +synonym: "downregulation of circadian rhythm" EXACT [] +synonym: "inhibition of circadian rhythm" NARROW [] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0007623 ! circadian rhythm + +[Term] +id: GO:0042755 +name: eating behavior +namespace: biological_process +def: "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, PMID:19361967] +synonym: "eating behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior + +[Term] +id: GO:0042756 +name: drinking behavior +namespace: biological_process +def: "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr] +synonym: "drinking behaviour" EXACT [] +is_a: GO:0007631 ! feeding behavior + +[Term] +id: GO:0042757 +name: giant axon +namespace: cellular_component +def: "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477] +is_a: GO:0030424 ! axon + +[Term] +id: GO:0042758 +name: long-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22." [PMID:20043225] +synonym: "long-chain fatty acid breakdown" EXACT [] +synonym: "long-chain fatty acid catabolism" EXACT [] +synonym: "long-chain fatty acid degradation" EXACT [] +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0009062 ! fatty acid catabolic process + +[Term] +id: GO:0042759 +name: long-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [PMID:18390550] +synonym: "long-chain fatty acid anabolism" EXACT [] +synonym: "long-chain fatty acid biosynthesis" EXACT [] +synonym: "long-chain fatty acid formation" EXACT [] +synonym: "long-chain fatty acid synthesis" EXACT [] +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042760 +name: very long-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [PMID:7744868] +synonym: "very-long-chain fatty acid breakdown" EXACT [] +synonym: "very-long-chain fatty acid catabolic process" EXACT [] +synonym: "very-long-chain fatty acid catabolism" EXACT [] +synonym: "very-long-chain fatty acid degradation" EXACT [] +is_a: GO:0000038 ! very long-chain fatty acid metabolic process +is_a: GO:0009062 ! fatty acid catabolic process + +[Term] +id: GO:0042761 +name: very long-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [PMID:7744868] +synonym: "very-long-chain fatty acid anabolism" EXACT [] +synonym: "very-long-chain fatty acid biosynthesis" EXACT [] +synonym: "very-long-chain fatty acid biosynthetic process" EXACT [] +synonym: "very-long-chain fatty acid formation" EXACT [] +synonym: "very-long-chain fatty acid synthesis" EXACT [] +xref: MetaCyc:PWY-5080 +is_a: GO:0000038 ! very long-chain fatty acid metabolic process +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0042762 +name: regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators] +synonym: "regulation of sulfur metabolism" EXACT [] +synonym: "regulation of sulphur metabolic process" EXACT [] +synonym: "regulation of sulphur metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0042763 +name: intracellular immature spore +namespace: cellular_component +def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] +synonym: "forespore" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0042764 +name: ascospore-type prospore +namespace: cellular_component +def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators] +is_a: GO:0042763 ! intracellular immature spore + +[Term] +id: GO:0042765 +name: GPI-anchor transamidase complex +namespace: cellular_component +def: "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054] +comment: Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. +synonym: "GPIT complex" EXACT [] +is_a: GO:0008303 ! caspase complex +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane + +[Term] +id: GO:0042766 +name: nucleosome mobilization +namespace: biological_process +def: "The movement of nucleosomes along a DNA fragment." [PMID:12006495] +synonym: "nucleosome sliding" EXACT [GOC:dph] +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0042767 +name: ecdysteroid 22-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 22." [PMID:12177427] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0042768 +name: ecdysteroid 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of an ecdysteroid at carbon position 2." [PMID:12177427] +comment: Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0042769 +name: obsolete DNA damage response, detection of DNA damage +namespace: biological_process +def: "OBSOLETE. The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators] +comment: This term has been obsoleted because it represents a molecular function. +synonym: "detection of DNA damage during DNA damage response" EXACT [] +synonym: "DNA damage response, perception of DNA damage" RELATED [] +is_obsolete: true +consider: GO:0006281 +consider: GO:0140612 +consider: GO:0140664 + +[Term] +id: GO:0042770 +name: signal transduction in response to DNA damage +namespace: biological_process +def: "A cascade of processes induced by the detection of DNA damage within a cell." [GOC:go_curators] +synonym: "DNA damage response, signal transduction" EXACT [] +synonym: "response to DNA damage stimulus by intracellular signaling cascade" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006974 ! cellular response to DNA damage stimulus +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0042771 +name: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [] +is_a: GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator + +[Term] +id: GO:0042772 +name: DNA damage response, signal transduction resulting in transcription +namespace: biological_process +def: "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators] +is_a: GO:0042770 ! signal transduction in response to DNA damage + +[Term] +id: GO:0042773 +name: ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] +is_a: GO:0022904 ! respiratory electron transport chain +relationship: part_of GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0042774 +name: plasma membrane ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363] +is_a: GO:0042773 ! ATP synthesis coupled electron transport + +[Term] +id: GO:0042775 +name: mitochondrial ATP synthesis coupled electron transport +namespace: biological_process +def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363] +synonym: "mitochondrial electron transport" BROAD [] +synonym: "organelle ATP synthesis coupled electron transport" BROAD [] +is_a: GO:0042773 ! ATP synthesis coupled electron transport + +[Term] +id: GO:0042776 +name: mitochondrial ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] +synonym: "mitochondrial proton transport" BROAD [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0015986 ! ATP synthesis coupled proton transport +is_a: GO:1990542 ! mitochondrial transmembrane transport +relationship: part_of GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0042777 +name: plasma membrane ATP synthesis coupled proton transport +namespace: biological_process +def: "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363] +synonym: "ATP synthesis coupled proton transport" BROAD [] +is_a: GO:0015986 ! ATP synthesis coupled proton transport + +[Term] +id: GO:0042778 +name: tRNA end turnover +namespace: biological_process +def: "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators] +is_a: GO:0006399 ! tRNA metabolic process + +[Term] +id: GO:0042779 +name: tRNA 3'-trailer cleavage +namespace: biological_process +def: "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators] +synonym: "removal of tRNA 3'-trailer sequence" EXACT [] +synonym: "tRNA 3'-end cleavage" EXACT [] +is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis +relationship: part_of GO:0042780 ! tRNA 3'-end processing + +[Term] +id: GO:0042780 +name: tRNA 3'-end processing +namespace: biological_process +def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] +synonym: "tRNA 3' processing" EXACT [] +is_a: GO:0008033 ! tRNA processing +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:0042781 +name: 3'-tRNA processing endoribonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [PMID:12032089, PMID:21208191] +synonym: "3 tRNase activity" RELATED [EC:3.1.26.11] +synonym: "3' tRNA processing endoribonuclease activity" EXACT [] +synonym: "3' tRNase activity" EXACT [] +synonym: "ribonuclease Z activity" BROAD [] +synonym: "RNase Z activity" BROAD [] +synonym: "tRNA 3 endonuclease activity" RELATED [EC:3.1.26.11] +synonym: "tRNA 3' endonuclease activity" EXACT [] +synonym: "tRNAse Z" RELATED [EC:3.1.26.11] +xref: EC:3.1.26.11 +xref: MetaCyc:3.1.26.11-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0042783 +name: evasion of host immune response +namespace: biological_process +alt_id: GO:0020012 +alt_id: GO:0042782 +alt_id: GO:0051805 +alt_id: GO:0051809 +alt_id: GO:0051810 +def: "A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb, PMID:12439615] +synonym: "active evasion of host immune response" RELATED [] +synonym: "active evasion of immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "active immune evasion" BROAD [] +synonym: "evasion or tolerance of host immune response" BROAD [] +synonym: "immune evasion" EXACT [] +synonym: "mitigation of host immune response" RELATED [] +synonym: "passive evasion of host immune response" RELATED [] +synonym: "passive evasion of immune response of other organism involved in symbiotic interaction" RELATED [] +synonym: "passive immune evasion" RELATED [] +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0042784 +name: evasion of host immune response via regulation of host complement system +namespace: biological_process +alt_id: GO:0051811 +def: "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] +synonym: "active evasion of host immune response via regulation of host complement system" RELATED [] +synonym: "active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction" BROAD [] +synonym: "active immune evasion via modulation of host complement system" EXACT [] +synonym: "active immune evasion via regulation of host complement system" EXACT [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0042785 +name: evasion of host immune response via regulation of host cytokine network +namespace: biological_process +alt_id: GO:0051812 +def: "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] +synonym: "active evasion of host immune response via regulation of host cytokine network" RELATED [] +synonym: "active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction" BROAD [] +synonym: "active immune evasion via modulation of host cytokine network" EXACT [] +synonym: "active immune evasion via regulation of host cytokine network" EXACT [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0042786 +name: evasion of host immune response via regulation of host antigen processing and presentation +namespace: biological_process +alt_id: GO:0051813 +def: "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615] +synonym: "active evasion of host immune response via regulation of host antigen processing and presentation" RELATED [] +synonym: "active evasion of host immune response via regulation of host antigen processing and presentation pathway" EXACT [] +synonym: "active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction" BROAD [] +synonym: "active immune evasion via modulation of antigen processing and presentation" EXACT [] +synonym: "active immune evasion via modulation of antigen processing/presentation" EXACT [] +synonym: "active immune evasion via regulation of antigen processing and presentation" EXACT [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0042788 +name: polysomal ribosome +namespace: cellular_component +def: "A ribosome bound to mRNA that forms part of a polysome." [GOC:jl] +synonym: "active ribosome" BROAD [] +is_a: GO:0005840 ! ribosome +relationship: part_of GO:0005844 ! polysome + +[Term] +id: GO:0042789 +name: mRNA transcription by RNA polymerase II +namespace: biological_process +def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382] +synonym: "mRNA transcription from Pol II promoter" EXACT [] +synonym: "mRNA transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006366 ! transcription by RNA polymerase II +is_a: GO:0009299 ! mRNA transcription + +[Term] +id: GO:0042790 +name: nucleolar large rRNA transcription by RNA polymerase I +namespace: biological_process +def: "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382] +synonym: "transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] +synonym: "transcription of nuclear rRNA large Pol I transcript" EXACT [] +synonym: "transcription of nucleolar large rRNA by RNA polymerase I" EXACT [] +is_a: GO:0006360 ! transcription by RNA polymerase I +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042791 +name: 5S class rRNA transcription by RNA polymerase III +namespace: biological_process +def: "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659] +synonym: "5S class rRNA transcription from RNA polymerase III type 1 promoter" RELATED [] +synonym: "5S rRNA transcription" EXACT [] +is_a: GO:0006383 ! transcription by RNA polymerase III +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042792 +name: mitochondrial rRNA transcription +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382] +synonym: "rRNA transcription from mitochondrial promoter" EXACT [] +is_a: GO:0006390 ! mitochondrial transcription +is_a: GO:0009303 ! rRNA transcription + +[Term] +id: GO:0042793 +name: plastid transcription +namespace: biological_process +def: "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] +synonym: "transcription from plastid promoter" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0042794 +name: plastid rRNA transcription +namespace: biological_process +def: "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382] +synonym: "rRNA transcription from plastid promoter" EXACT [] +is_a: GO:0009303 ! rRNA transcription +is_a: GO:0042793 ! plastid transcription + +[Term] +id: GO:0042795 +name: snRNA transcription by RNA polymerase II +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382] +synonym: "snRNA transcription from Pol II promoter" EXACT [] +synonym: "snRNA transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006366 ! transcription by RNA polymerase II +is_a: GO:0009301 ! snRNA transcription + +[Term] +id: GO:0042796 +name: snRNA transcription by RNA polymerase III +namespace: biological_process +def: "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] +synonym: "snRNA transcription from Pol III promoter" EXACT [] +synonym: "snRNA transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006383 ! transcription by RNA polymerase III +is_a: GO:0009301 ! snRNA transcription + +[Term] +id: GO:0042797 +name: tRNA transcription by RNA polymerase III +namespace: biological_process +def: "The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382] +synonym: "tRNA transcription from Pol III promoter" EXACT [] +synonym: "tRNA transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006383 ! transcription by RNA polymerase III +is_a: GO:0009304 ! tRNA transcription + +[Term] +id: GO:0042798 +name: obsolete protein neddylation during NEDD8 class-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl] +comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. +synonym: "protein neddylation during NEDD8 class-dependent protein breakdown" EXACT [] +synonym: "protein neddylation during NEDD8 class-dependent protein catabolic process" EXACT [] +synonym: "protein neddylation during NEDD8 class-dependent protein catabolism" EXACT [] +synonym: "protein neddylation during NEDD8 class-dependent protein degradation" EXACT [] +synonym: "protein neddylation during RUB1-dependent protein catabolic process" EXACT [] +synonym: "protein neddylation during RUB1-dependent protein catabolism" EXACT [] +is_obsolete: true +consider: GO:0045116 + +[Term] +id: GO:0042799 +name: histone methyltransferase activity (H4-K20 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618] +comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. +synonym: "histone H4 lysine 20-specific methyltransferase activity" EXACT [] +synonym: "histone lysine N-methyltransferase activity (H4-K20 specific)" EXACT [] +synonym: "histone methylase activity (H4-K20 specific)" EXACT [GOC:mah] +xref: Reactome:R-HSA-2301205 "SETD8 monomethylates histone H4" +xref: Reactome:R-HSA-5682965 "WHSC1 dimethylates histone H4 on lysine K21 at DSBs" +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0042800 +name: histone methyltransferase activity (H3-K4 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] +comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. +synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] +synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT [] +synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah] +xref: Reactome:R-HSA-1214188 "PRDM9 trimethylates histone H3" +xref: Reactome:R-HSA-3364026 "SET1 complex trimethylates H3K4 at the MYC gene" +xref: Reactome:R-HSA-8865498 "KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark" +xref: Reactome:R-HSA-8936481 "Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter" +xref: Reactome:R-HSA-8936621 "Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter" +xref: Reactome:R-HSA-8937016 "Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter" +xref: Reactome:R-HSA-8937050 "Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter" +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0042801 +name: obsolete polo kinase kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma] +comment: This term was made obsolete because it represents a gene product and also refers to a non-existent activity (polo kinase). +is_obsolete: true + +[Term] +id: GO:0042802 +name: identical protein binding +namespace: molecular_function +def: "Binding to an identical protein or proteins." [GOC:jl] +subset: goslim_chembl +synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655] +synonym: "protein homopolymerization" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042803 +name: protein homodimerization activity +namespace: molecular_function +def: "Binding to an identical protein to form a homodimer." [GOC:jl] +subset: goslim_chembl +synonym: "dimerization activity" BROAD [] +is_a: GO:0042802 ! identical protein binding +is_a: GO:0046983 ! protein dimerization activity + +[Term] +id: GO:0042804 +name: obsolete protein homooligomerization activity +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with identical proteins to form a homooligomer." [GOC:jl] +comment: This term was made obsolete because it represents a biological process. +synonym: "oligomerization activity" BROAD [] +synonym: "protein homooligomerization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051260 + +[Term] +id: GO:0042805 +name: actinin binding +namespace: molecular_function +alt_id: GO:0051406 +def: "Binding to actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732] +synonym: "beta-actinin binding" NARROW [] +synonym: "capZ binding" EXACT [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0042806 +name: fucose binding +namespace: molecular_function +def: "Binding to fucose, the pentose 6-deoxygalactose." [ISBN:0582227089] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0042807 +name: central vacuole +namespace: cellular_component +def: "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [ISBN:9780815341116, Wikipedia:Vacuole] +is_a: GO:0000325 ! plant-type vacuole + +[Term] +id: GO:0042808 +name: obsolete neuronal Cdc2-like kinase binding +namespace: molecular_function +def: "OBSOLETE. Binding to neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "neuronal Cdc2-like kinase binding" EXACT [] +is_obsolete: true +replaced_by: GO:0019901 + +[Term] +id: GO:0042809 +name: vitamin D receptor binding +namespace: molecular_function +def: "Binding to a vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589] +synonym: "calciferol receptor binding" NARROW [] +synonym: "VDR binding" EXACT [] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0042810 +name: pheromone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] +subset: goslim_pir +synonym: "pheromone metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042445 ! hormone metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0042811 +name: pheromone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] +synonym: "pheromone anabolism" EXACT [] +synonym: "pheromone biosynthesis" EXACT [] +synonym: "pheromone formation" EXACT [] +synonym: "pheromone synthesis" EXACT [] +is_a: GO:0042446 ! hormone biosynthetic process +is_a: GO:0042810 ! pheromone metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0042812 +name: pheromone catabolic process +namespace: biological_process +alt_id: GO:0007327 +alt_id: GO:0046614 +def: "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732] +synonym: "pheromone breakdown" EXACT [] +synonym: "pheromone catabolism" EXACT [] +synonym: "pheromone degradation" EXACT [] +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0042810 ! pheromone metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0042813 +name: Wnt-activated receptor activity +namespace: molecular_function +def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators] +subset: goslim_chembl +synonym: "frizzled receptor activity" RELATED [] +synonym: "frizzled-2 receptor activity" RELATED [] +synonym: "Wnt receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0042814 +name: monopolar cell growth +namespace: biological_process +def: "Polarized growth from one end of a cell." [GOC:vw] +synonym: "monopolar cell elongation" NARROW [] +synonym: "monopolar growth" BROAD [] +synonym: "polar cell elongation" NARROW [] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0042815 +name: bipolar cell growth +namespace: biological_process +def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw] +comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children. +synonym: "bipolar cell elongation" NARROW [] +synonym: "bipolar growth" BROAD [] +synonym: "polar cell elongation" RELATED [] +is_a: GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0042816 +name: vitamin B6 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "vitamin B6 metabolism" EXACT [] +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0042817 +name: pyridoxal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/] +synonym: "pyridoxal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042818 +name: pyridoxamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl] +synonym: "pyridoxamine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042819 +name: vitamin B6 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "pyridoxine-5'-phosphate biosynthesis" RELATED [GOC:yaf, UniPathway:UPA00244] +synonym: "vitamin B6 anabolism" EXACT [] +synonym: "vitamin B6 biosynthesis" EXACT [] +synonym: "vitamin B6 formation" EXACT [] +synonym: "vitamin B6 synthesis" EXACT [] +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process + +[Term] +id: GO:0042820 +name: vitamin B6 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] +synonym: "vitamin B6 breakdown" EXACT [] +synonym: "vitamin B6 catabolism" EXACT [] +synonym: "vitamin B6 degradation" EXACT [] +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process + +[Term] +id: GO:0042821 +name: pyridoxal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/] +synonym: "pyridoxal anabolism" EXACT [] +synonym: "pyridoxal biosynthesis" EXACT [] +synonym: "pyridoxal formation" EXACT [] +synonym: "pyridoxal synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042817 ! pyridoxal metabolic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0042822 +name: pyridoxal phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl] +synonym: "active vitamin B6 metabolic process" EXACT [] +synonym: "active vitamin B6 metabolism" EXACT [] +synonym: "pyridoxal phosphate metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0042816 ! vitamin B6 metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042823 +name: pyridoxal phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl] +synonym: "active vitamin B6 biosynthesis" EXACT [] +synonym: "active vitamin B6 biosynthetic process" EXACT [] +synonym: "pyridoxal phosphate anabolism" EXACT [] +synonym: "pyridoxal phosphate biosynthesis" EXACT [] +synonym: "pyridoxal phosphate formation" EXACT [] +synonym: "pyridoxal phosphate synthesis" EXACT [] +xref: MetaCyc:PWY0-845 +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0042819 ! vitamin B6 biosynthetic process +is_a: GO:0042822 ! pyridoxal phosphate metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0042824 +name: MHC class I peptide loading complex +namespace: cellular_component +def: "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934] +comment: Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. +subset: goslim_pir +synonym: "peptide-loading complex" EXACT [GOC:bhm] +synonym: "PLC" RELATED [GOC:bhm] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane + +[Term] +id: GO:0042825 +name: TAP complex +namespace: cellular_component +def: "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934] +synonym: "transporter associated with antigen presentation" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0042824 ! MHC class I peptide loading complex + +[Term] +id: GO:0042826 +name: histone deacetylase binding +namespace: molecular_function +def: "Binding to histone deacetylase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0042827 +name: platelet dense granule +namespace: cellular_component +def: "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, PMID:10403682, PMID:11487378] +synonym: "bull's eye body" EXACT [] +synonym: "platelet dense body" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0042832 +name: defense response to protozoan +namespace: biological_process +alt_id: GO:0009818 +def: "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl] +synonym: "defence response to pathogenic protozoa" EXACT [] +synonym: "defence response to protozoa" EXACT [] +synonym: "defence response to protozoon" EXACT [] +synonym: "defense response to pathogenic protozoa" EXACT [] +synonym: "defense response to protozoa" EXACT [] +synonym: "defense response to protozoan, incompatible interaction" NARROW [] +synonym: "defense response to protozoon" EXACT [] +synonym: "resistance response to pathogenic protozoa" NARROW [] +synonym: "resistance response to pathogenic protozoan" NARROW [] +is_a: GO:0001562 ! response to protozoan +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0042834 +name: peptidoglycan binding +namespace: molecular_function +def: "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226] +is_a: GO:0005539 ! glycosaminoglycan binding + +[Term] +id: GO:0042835 +name: BRE binding +namespace: molecular_function +def: "Binding to a BRE RNA element (Bruno response element)." [PMID:10893231] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0042836 +name: D-glucarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-glucarate metabolism" EXACT [] +synonym: "saccharate metabolic process" EXACT [] +synonym: "saccharate metabolism" EXACT [] +is_a: GO:0019392 ! glucarate metabolic process + +[Term] +id: GO:0042837 +name: D-glucarate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-glucarate anabolism" EXACT [] +synonym: "D-glucarate biosynthesis" EXACT [] +synonym: "D-glucarate formation" EXACT [] +synonym: "D-glucarate synthesis" EXACT [] +synonym: "saccharate biosynthesis" EXACT [] +synonym: "saccharate biosynthetic process" EXACT [] +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0019393 ! glucarate biosynthetic process +is_a: GO:0042836 ! D-glucarate metabolic process + +[Term] +id: GO:0042838 +name: D-glucarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-glucarate breakdown" EXACT [] +synonym: "D-glucarate catabolism" EXACT [] +synonym: "D-glucarate degradation" EXACT [] +synonym: "saccharate catabolic process" EXACT [] +synonym: "saccharate catabolism" EXACT [] +is_a: GO:0019394 ! glucarate catabolic process +is_a: GO:0042836 ! D-glucarate metabolic process + +[Term] +id: GO:0042839 +name: D-glucuronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "D-glucuronate metabolism" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process + +[Term] +id: GO:0042840 +name: D-glucuronate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "D-glucuronate breakdown" EXACT [] +synonym: "D-glucuronate catabolism" EXACT [] +synonym: "D-glucuronate degradation" EXACT [] +is_a: GO:0006064 ! glucuronate catabolic process +is_a: GO:0042839 ! D-glucuronate metabolic process + +[Term] +id: GO:0042841 +name: D-glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "D-glucuronate anabolism" EXACT [] +synonym: "D-glucuronate biosynthesis" EXACT [] +synonym: "D-glucuronate formation" EXACT [] +synonym: "D-glucuronate synthesis" EXACT [] +is_a: GO:0042839 ! D-glucuronate metabolic process +is_a: GO:0046399 ! glucuronate biosynthetic process + +[Term] +id: GO:0042842 +name: D-xylose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] +synonym: "D-xylose anabolism" EXACT [] +synonym: "D-xylose biosynthesis" EXACT [] +synonym: "D-xylose formation" EXACT [] +synonym: "D-xylose synthesis" EXACT [] +is_a: GO:0019322 ! pentose biosynthetic process +is_a: GO:0042732 ! D-xylose metabolic process + +[Term] +id: GO:0042843 +name: D-xylose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732] +synonym: "D-xylose breakdown" EXACT [] +synonym: "D-xylose catabolism" EXACT [] +synonym: "D-xylose degradation" EXACT [] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0042732 ! D-xylose metabolic process + +[Term] +id: GO:0042844 +name: glycol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [PMID:9851711] +synonym: "dihydric alcohol metabolic process" BROAD [] +synonym: "dihydric alcohol metabolism" BROAD [] +synonym: "glycol metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:0042845 +name: glycol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [GOC:curators] +synonym: "dihydric alcohol biosynthesis" BROAD [] +synonym: "dihydric alcohol biosynthetic process" BROAD [] +synonym: "glycol anabolism" EXACT [] +synonym: "glycol biosynthesis" EXACT [] +synonym: "glycol formation" EXACT [] +synonym: "glycol synthesis" EXACT [] +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0042844 ! glycol metabolic process + +[Term] +id: GO:0042846 +name: glycol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [Wikipedia:Ethylene_glycol] +synonym: "dihydric alcohol catabolic process" BROAD [] +synonym: "dihydric alcohol catabolism" BROAD [] +synonym: "glycol breakdown" EXACT [] +synonym: "glycol catabolism" EXACT [] +synonym: "glycol degradation" EXACT [] +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0042844 ! glycol metabolic process + +[Term] +id: GO:0042847 +name: sorbose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] +synonym: "sorbose anabolism" EXACT [] +synonym: "sorbose biosynthesis" EXACT [] +synonym: "sorbose formation" EXACT [] +synonym: "sorbose synthesis" EXACT [] +is_a: GO:0019311 ! sorbose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0042848 +name: sorbose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] +synonym: "sorbose breakdown" EXACT [] +synonym: "sorbose catabolism" EXACT [] +synonym: "sorbose degradation" EXACT [] +is_a: GO:0019311 ! sorbose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0042849 +name: L-sorbose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [ISBN:0198506732] +synonym: "L-sorbose anabolism" EXACT [] +synonym: "L-sorbose biosynthesis" EXACT [] +synonym: "L-sorbose formation" EXACT [] +synonym: "L-sorbose synthesis" EXACT [] +is_a: GO:0019312 ! L-sorbose metabolic process +is_a: GO:0042847 ! sorbose biosynthetic process + +[Term] +id: GO:0042850 +name: L-sorbose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-sorbose breakdown" EXACT [] +synonym: "L-sorbose catabolism" EXACT [] +synonym: "L-sorbose degradation" EXACT [] +is_a: GO:0019312 ! L-sorbose metabolic process +is_a: GO:0042848 ! sorbose catabolic process + +[Term] +id: GO:0042851 +name: L-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "L-alanine metabolism" EXACT [] +is_a: GO:0006522 ! alanine metabolic process + +[Term] +id: GO:0042852 +name: L-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "L-alanine anabolism" EXACT [] +synonym: "L-alanine biosynthesis" EXACT [] +synonym: "L-alanine formation" EXACT [] +synonym: "L-alanine synthesis" EXACT [] +is_a: GO:0006523 ! alanine biosynthetic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0042853 +name: L-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "L-alanine breakdown" EXACT [] +synonym: "L-alanine catabolism" EXACT [] +synonym: "L-alanine degradation" EXACT [] +is_a: GO:0006524 ! alanine catabolic process +is_a: GO:0042851 ! L-alanine metabolic process + +[Term] +id: GO:0042854 +name: eugenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] +synonym: "4-allyl-2-methoxyphenol metabolic process" EXACT [] +synonym: "4-allyl-2-methoxyphenol metabolism" EXACT [] +synonym: "eugenic acid metabolic process" EXACT [] +synonym: "eugenic acid metabolism" EXACT [] +synonym: "eugenol metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0042855 +name: eugenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] +synonym: "4-allyl-2-methoxyphenol biosynthesis" EXACT [] +synonym: "4-allyl-2-methoxyphenol biosynthetic process" EXACT [] +synonym: "eugenic acid biosynthesis" EXACT [] +synonym: "eugenic acid biosynthetic process" EXACT [] +synonym: "eugenol anabolism" EXACT [] +synonym: "eugenol biosynthesis" EXACT [] +synonym: "eugenol formation" EXACT [] +synonym: "eugenol synthesis" EXACT [] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0042854 ! eugenol metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0042856 +name: eugenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [GOC:jl] +synonym: "4-allyl-2-methoxyphenol catabolic process" EXACT [] +synonym: "4-allyl-2-methoxyphenol catabolism" EXACT [] +synonym: "eugenic acid catabolic process" EXACT [] +synonym: "eugenic acid catabolism" EXACT [] +synonym: "eugenol breakdown" EXACT [] +synonym: "eugenol catabolism" EXACT [] +synonym: "eugenol degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042854 ! eugenol metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0042857 +name: chrysobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +synonym: "chrysobactin metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0042858 +name: chrysobactin biosynthetic process +namespace: biological_process +alt_id: GO:0031183 +alt_id: GO:0031184 +def: "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +synonym: "chrysobactin anabolism" EXACT [] +synonym: "chrysobactin biosynthesis" EXACT [] +synonym: "chrysobactin biosynthetic process, peptide formation" NARROW [] +synonym: "chrysobactin biosynthetic process, peptide modification" NARROW [] +synonym: "chrysobactin formation" EXACT [] +synonym: "chrysobactin synthesis" EXACT [] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042857 ! chrysobactin metabolic process +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:0042859 +name: chrysobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459] +synonym: "chrysobactin breakdown" EXACT [] +synonym: "chrysobactin catabolism" EXACT [] +synonym: "chrysobactin degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0042857 ! chrysobactin metabolic process +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0046215 ! siderophore catabolic process +is_a: GO:1901161 ! primary amino compound catabolic process + +[Term] +id: GO:0042860 +name: achromobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +synonym: "achromobactin metabolism" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0042861 +name: achromobactin biosynthetic process +namespace: biological_process +alt_id: GO:0031181 +alt_id: GO:0031182 +def: "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +synonym: "achromobactin anabolism" EXACT [] +synonym: "achromobactin biosynthesis" EXACT [] +synonym: "achromobactin formation" EXACT [] +synonym: "achromobactin synthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0042860 ! achromobactin metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0042862 +name: achromobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541] +synonym: "achromobactin breakdown" EXACT [] +synonym: "achromobactin catabolism" EXACT [] +synonym: "achromobactin degradation" EXACT [] +is_a: GO:0042860 ! achromobactin metabolic process +is_a: GO:0046215 ! siderophore catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0042863 +name: pyochelin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +synonym: "pyochelin metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0042864 +name: pyochelin biosynthetic process +namespace: biological_process +alt_id: GO:0031187 +alt_id: GO:0031188 +def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +synonym: "pyochelin anabolism" EXACT [] +synonym: "pyochelin biosynthesis" EXACT [] +synonym: "pyochelin biosynthetic process, peptide formation" NARROW [] +synonym: "pyochelin biosynthetic process, peptide modification" NARROW [] +synonym: "pyochelin formation" EXACT [] +synonym: "pyochelin synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0042863 ! pyochelin metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0042865 +name: pyochelin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030] +synonym: "pyochelin breakdown" EXACT [] +synonym: "pyochelin catabolism" EXACT [] +synonym: "pyochelin degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042863 ! pyochelin metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046215 ! siderophore catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0042866 +name: pyruvate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators] +synonym: "pyruvate anabolism" EXACT [] +synonym: "pyruvate biosynthesis" EXACT [] +synonym: "pyruvate formation" EXACT [] +synonym: "pyruvate synthesis" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0042867 +name: pyruvate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators] +synonym: "pyruvate breakdown" EXACT [] +synonym: "pyruvate catabolism" EXACT [] +synonym: "pyruvate degradation" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0042868 +name: antisense RNA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl] +synonym: "antisense RNA metabolism" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0042869 +name: aldarate transmembrane transport +namespace: biological_process +def: "The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] +synonym: "aldarate transport" RELATED [] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0042870 +name: D-glucarate transmembrane transport +namespace: biological_process +def: "The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-glucarate transport" RELATED [] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0042869 ! aldarate transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0042873 +name: aldonate transmembrane transport +namespace: biological_process +def: "The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] +synonym: "aldonate transport" RELATED [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0042874 +name: D-glucuronate transmembrane transport +namespace: biological_process +def: "The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "D-glucuronate transport" RELATED [] +is_a: GO:0015738 ! glucuronate transmembrane transport + +[Term] +id: GO:0042875 +name: D-galactonate transmembrane transport +namespace: biological_process +def: "The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah] +synonym: "D-galactonate transport" RELATED [] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0042873 ! aldonate transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0042876 +name: aldarate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of aldarate from one side of a membrane to the other." [GOC:go_curators, PMID:15034926] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0042878 +name: D-glucarate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0042876 ! aldarate transmembrane transporter activity + +[Term] +id: GO:0042879 +name: aldonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of aldonate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0042880 +name: D-glucuronate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0015135 ! glucuronate transmembrane transporter activity + +[Term] +id: GO:0042881 +name: D-galactonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:0042882 +name: L-arabinose transmembrane transport +namespace: biological_process +def: "The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-arabinose transport" RELATED [] +is_a: GO:0015751 ! arabinose transmembrane transport + +[Term] +id: GO:0042883 +name: cysteine transport +namespace: biological_process +def: "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] +synonym: "L-cysteine transport" NARROW [] +is_a: GO:0000101 ! sulfur amino acid transport +is_a: GO:0006812 ! cation transport +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0042884 +name: microcin transport +namespace: biological_process +def: "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0042885 +name: microcin B17 transport +namespace: biological_process +def: "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337] +is_a: GO:0042884 ! microcin transport + +[Term] +id: GO:0042886 +name: amide transport +namespace: biological_process +def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] +subset: goslim_pir +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0042887 +name: amide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] +synonym: "amine/amide/polyamine channel activity" NARROW [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0042888 +name: molybdenum ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity + +[Term] +id: GO:0042889 +name: 3-phenylpropionic acid transport +namespace: biological_process +def: "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "3-phenylpropionate transport" EXACT [] +synonym: "HCA transport" EXACT [] +synonym: "hydrocinnamic acid transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0042890 +name: 3-phenylpropionic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other." [GOC:jl] +synonym: "3-phenylpropionate acid transporter activity" EXACT [] +synonym: "HCA transporter activity" EXACT [] +synonym: "hydrocinnamic acid transporter activity" EXACT [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0042891 +name: obsolete antibiotic transport +namespace: biological_process +def: "OBSOLETE. The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +comment: The reason for obsoletion is that this term has been inconsistently used. For export of an antibiotic by the organism that synthesizes it, consider 'GO:0140115 ; export across plasma membrane'. For export of an antibiotic by the target organism, consider 'GO:1990961 ; xenobiotic detoxification by transmembrane export across the plasma membrane'. +is_obsolete: true + +[Term] +id: GO:0042892 +name: chloramphenicol transmembrane transport +namespace: biological_process +def: "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other." [PMID:29150447] +synonym: "chloramphenicol transport" BROAD [] +is_a: GO:0015791 ! polyol transport +is_a: GO:0042886 ! amide transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0042893 +name: polymyxin transport +namespace: biological_process +def: "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0042894 +name: fosmidomycin transport +namespace: biological_process +def: "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685] +is_a: GO:0042886 ! amide transport +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0042895 +name: obsolete antibiotic transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, from one side of a membrane to the other." [GOC:jl] +comment: The reason for obsoletion is that this term has been inconsistently used. Consider annotating to 'GO:0042910 ; xenobiotic transmembrane transporter activity' and the specific solute being transported as an annotation extension. +synonym: "antibiotic transporter activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0042896 +name: chloramphenicol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other." [GOC:jl] +synonym: "chloramphenicol transporter activity" RELATED [] +is_a: GO:0015166 ! polyol transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0042897 +name: polymyxin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other." [GOC:jl, ISBN:0198506732] +synonym: "polymyxin transporter activity" RELATED [] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0042898 +name: fosmidomycin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other." [GOC:jl, PMID:12543685] +synonym: "fosmidomycin transporter activity" RELATED [] +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:0042899 +name: arabinan transmembrane transport +namespace: biological_process +def: "The process in which arabinan is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:jl] +synonym: "arabinan transport" RELATED [] +is_a: GO:0015774 ! polysaccharide transport +is_a: GO:0034219 ! carbohydrate transmembrane transport + +[Term] +id: GO:0042900 +name: arabinose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015146 ! pentose transmembrane transporter activity + +[Term] +id: GO:0042901 +name: arabinan transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0042902 +name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345] +xref: RESID:AA0345 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0042903 +name: tubulin deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003] +xref: Reactome:R-HSA-5618331 "HDAC6 deacetylates microtubules" +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0033558 ! protein deacetylase activity + +[Term] +id: GO:0042904 +name: 9-cis-retinoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] +synonym: "9-cis-retinoic acid anabolism" EXACT [] +synonym: "9-cis-retinoic acid biosynthesis" EXACT [] +synonym: "9-cis-retinoic acid formation" EXACT [] +synonym: "9-cis-retinoic acid synthesis" EXACT [] +is_a: GO:0002138 ! retinoic acid biosynthetic process +is_a: GO:0042905 ! 9-cis-retinoic acid metabolic process + +[Term] +id: GO:0042905 +name: 9-cis-retinoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029] +synonym: "9-cis-retinoic acid metabolism" EXACT [] +is_a: GO:0042573 ! retinoic acid metabolic process + +[Term] +id: GO:0042906 +name: xanthine transport +namespace: biological_process +def: "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] +synonym: "xanthine transmembrane transport" EXACT [GOC:mah] +is_a: GO:0006863 ! purine nucleobase transport + +[Term] +id: GO:0042907 +name: xanthine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl] +is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity + +[Term] +id: GO:0042908 +name: xenobiotic transport +namespace: biological_process +alt_id: GO:0015893 +def: "The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc] +subset: goslim_pir +synonym: "drug transport" RELATED [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0042909 +name: acridine transport +namespace: biological_process +def: "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, Wikipedia:Acridine] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0042910 +name: xenobiotic transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015238 +alt_id: GO:0015239 +alt_id: GO:0015559 +alt_id: GO:0015564 +alt_id: GO:0090484 +def: "Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc] +subset: goslim_metagenomics +synonym: "drug transmembrane transporter activity" RELATED [] +synonym: "drug transporter activity" RELATED [] +synonym: "multidrug efflux pump activity" RELATED [] +synonym: "multidrug transporter activity" RELATED [] +synonym: "multidrug, alkane resistant pump activity" RELATED [] +synonym: "xenobiotic transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0042911 +name: acridine transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other." [GOC:jl] +synonym: "acridine transporter activity" RELATED [] +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0042912 +name: colicin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522] +is_a: GO:0022885 ! bacteriocin transmembrane transporter activity + +[Term] +id: GO:0042913 +name: group A colicin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417] +is_a: GO:0042912 ! colicin transmembrane transporter activity + +[Term] +id: GO:0042914 +name: colicin transport +namespace: biological_process +def: "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522] +is_a: GO:0043213 ! bacteriocin transport + +[Term] +id: GO:0042915 +name: group A colicin transport +namespace: biological_process +def: "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417] +is_a: GO:0042914 ! colicin transport + +[Term] +id: GO:0042918 +name: alkanesulfonate transport +namespace: biological_process +def: "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [GOC:jl] +synonym: "alkanesulphonate transport" EXACT [] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0042919 +name: benzoate transport +namespace: biological_process +def: "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:0042920 +name: 3-hydroxyphenylpropionic acid transmembrane transport +namespace: biological_process +def: "The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] +synonym: "3-(3-hydroxyphenyl)propionic acid transport" EXACT [] +synonym: "3-hydroxyphenylpropionic acid transport" BROAD [] +synonym: "m-hydroxyphenylpropionic acid transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0042921 +name: glucocorticoid receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah] +synonym: "glucocorticoid receptor signalling pathway" EXACT [] +is_a: GO:0031958 ! corticosteroid receptor signaling pathway + +[Term] +id: GO:0042922 +name: neuromedin U receptor binding +namespace: molecular_function +def: "Binding to one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0042923 +name: neuropeptide binding +namespace: molecular_function +def: "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0042924 +name: neuromedin U binding +namespace: molecular_function +def: "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108] +synonym: "NMU binding" EXACT [] +is_a: GO:0042923 ! neuropeptide binding + +[Term] +id: GO:0042925 +name: benzoate transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other." [GOC:jl, ISBN:0721662544] +synonym: "benzoate transporter activity" RELATED [] +xref: RHEA:32811 +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:0042926 +name: 3-hydroxyphenylpropionic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other." [GOC:jl] +synonym: "3-(3-hydroxyphenyl)propionic acid transporter activity" EXACT [] +synonym: "3-hydroxyphenylpropionic acid transporter activity" RELATED [] +synonym: "m-hydroxyphenylpropionic acid transporter activity" EXACT [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0042928 +name: ferrichrome import into cell +namespace: biological_process +def: "A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732, PMID:23192658] +synonym: "ferrichrome transport" BROAD [] +is_a: GO:0015687 ! ferric-hydroxamate import into cell +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0042929 +name: ferrichrome transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732] +synonym: "ferrichrome transporter activity" RELATED [] +is_a: GO:0015343 ! siderophore transmembrane transporter activity +is_a: GO:0015603 ! iron chelate transmembrane transporter activity +is_a: GO:1904680 ! peptide transmembrane transporter activity + +[Term] +id: GO:0042930 +name: enterobactin transport +namespace: biological_process +def: "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "enterochelin transport" EXACT [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0015891 ! siderophore transport + +[Term] +id: GO:0042931 +name: enterobactin transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other." [GOC:jl] +synonym: "enterobactin transporter activity" RELATED [] +synonym: "enterochelin transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015343 ! siderophore transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0042932 +name: chrysobactin transport +namespace: biological_process +def: "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459] +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0015891 ! siderophore transport +is_a: GO:0042938 ! dipeptide transport + +[Term] +id: GO:0042933 +name: chrysobactin transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other." [GOC:jl, PMID:8837459] +synonym: "chrysobactin transporter activity" RELATED [] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015343 ! siderophore transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:0071916 ! dipeptide transmembrane transporter activity + +[Term] +id: GO:0042934 +name: achromobactin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other." [GOC:jl] +synonym: "achromobactin transporter activity" RELATED [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015343 ! siderophore transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0042935 +name: achromobactin transport +namespace: biological_process +def: "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541] +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0015891 ! siderophore transport +is_a: GO:0042886 ! amide transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0042937 +name: tripeptide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other." [GOC:jl] +synonym: "tripeptide transporter activity" RELATED [] +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:0042938 +name: dipeptide transport +namespace: biological_process +def: "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0006857 ! oligopeptide transport + +[Term] +id: GO:0042939 +name: tripeptide transport +namespace: biological_process +def: "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0006857 ! oligopeptide transport + +[Term] +id: GO:0042940 +name: D-amino acid transport +namespace: biological_process +def: "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] +is_a: GO:0006865 ! amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0042941 +name: D-alanine transport +namespace: biological_process +def: "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] +is_a: GO:0032328 ! alanine transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0042942 +name: D-serine transport +namespace: biological_process +def: "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah] +is_a: GO:0032329 ! serine transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0042943 +name: D-amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] +synonym: "D-amino acid transporter activity" BROAD [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0042944 +name: D-alanine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +synonym: "D-alanine transporter activity" BROAD [] +is_a: GO:0022858 ! alanine transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity + +[Term] +id: GO:0042945 +name: D-serine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] +synonym: "D-serine permease activity" EXACT [] +synonym: "D-serine transporter activity" BROAD [] +is_a: GO:0022889 ! serine transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity + +[Term] +id: GO:0042946 +name: glucoside transport +namespace: biological_process +def: "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732] +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0042947 +name: glucoside transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0042948 +name: salicin transport +namespace: biological_process +def: "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0015759 ! beta-glucoside transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0042949 +name: arbutin transport +namespace: biological_process +def: "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:19965875] +is_a: GO:0015759 ! beta-glucoside transport + +[Term] +id: GO:0042950 +name: salicin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0042951 +name: arbutin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, PMID:19965875] +is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity + +[Term] +id: GO:0042952 +name: beta-ketoadipate pathway +namespace: biological_process +def: "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091] +synonym: "ortho-cleavage pathway" BROAD [] +is_a: GO:0019439 ! aromatic compound catabolic process + +[Term] +id: GO:0042953 +name: lipoprotein transport +namespace: biological_process +def: "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] +is_a: GO:0015031 ! protein transport +is_a: GO:0044872 ! lipoprotein localization + +[Term] +id: GO:0042954 +name: obsolete lipoprotein transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732] +comment: The reason for obsoletion is this term has been incorrectly used. +is_obsolete: true + +[Term] +id: GO:0042955 +name: dextrin transport +namespace: biological_process +def: "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0042956 +name: maltodextrin transport +namespace: biological_process +def: "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0015774 ! polysaccharide transport + +[Term] +id: GO:0042957 +name: dextrin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other." [GOC:jl, GOC:vk] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0042958 +name: maltodextrin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other." [GOC:jl, PMID:15034926] +is_a: GO:0015159 ! polysaccharide transmembrane transporter activity + +[Term] +id: GO:0042959 +name: alkanesulfonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of alkanesulfonate from one side of a membrane to the other." [GOC:jl] +synonym: "alkanesulfonate transporter activity" RELATED [] +synonym: "alkanesulphonate transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:0042960 +name: antimonite secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl] +synonym: "antimonite porter activity" RELATED [] +is_a: GO:0015104 ! antimonite transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0042961 +name: ATPase-coupled antimonite transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:7.3.2.7] +synonym: "antimonite-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent antimonite transporter activity" EXACT [] +is_a: GO:0015104 ! antimonite transmembrane transporter activity +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity + +[Term] +id: GO:0042962 +name: acridine:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876] +synonym: "acridine efflux pump activity" RELATED [] +synonym: "acridine:hydrogen antiporter activity" EXACT [] +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0042964 +name: obsolete thioredoxin reduction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the reduction of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "thioredoxin anabolism" EXACT [] +synonym: "thioredoxin biosynthesis" EXACT [] +synonym: "thioredoxin formation" EXACT [] +synonym: "thioredoxin synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0042965 +name: obsolete glutaredoxin biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators] +comment: This term was made obsolete because it refers to the biosynthesis of a protein. +synonym: "glutaredoxin anabolism" EXACT [] +synonym: "glutaredoxin biosynthesis" EXACT [] +synonym: "glutaredoxin formation" EXACT [] +synonym: "glutaredoxin synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0042966 +name: biotin carboxyl carrier protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363] +synonym: "BCCP biosynthesis" EXACT [] +synonym: "BCCP biosynthetic process" EXACT [] +synonym: "biotin carboxyl carrier protein anabolism" EXACT [] +synonym: "biotin carboxyl carrier protein biosynthesis" EXACT [] +synonym: "biotin carboxyl carrier protein formation" EXACT [] +synonym: "biotin carboxyl carrier protein synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0042967 +name: obsolete acyl-carrier-protein biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators] +comment: The reason for obsoletion is that acyl-carrier-protein is synthesized by the ribosome like any other protein. +synonym: "ACP biosynthesis" EXACT [] +synonym: "ACP biosynthetic process" EXACT [] +synonym: "acyl carrier protein biosynthesis" EXACT [] +synonym: "acyl carrier protein biosynthetic process" EXACT [] +synonym: "acyl-carrier protein biosynthesis" EXACT [] +synonym: "acyl-carrier-protein anabolism" EXACT [] +synonym: "acyl-carrier-protein biosynthesis" EXACT [] +synonym: "acyl-carrier-protein formation" EXACT [] +synonym: "acyl-carrier-protein synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0042968 +name: homoserine transport +namespace: biological_process +def: "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0042969 +name: obsolete lactone transport +namespace: biological_process +def: "OBSOLETE. The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators] +comment: This term aws obsoleted because there is no evidence for a specific pathway to transport lactone. +is_obsolete: true + +[Term] +id: GO:0042970 +name: homoserine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732] +synonym: "homoserine transporter activity" BROAD [] +is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0042971 +name: obsolete lactone transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:go_curators] +comment: This term was obsoleted because there is no evidence for a specific lactone transporter. +is_obsolete: true + +[Term] +id: GO:0042972 +name: licheninase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds." [EC:3.2.1.73] +synonym: "1,3-1,4-beta-D-glucan 4-glucanohydrolase activity" EXACT [] +synonym: "1,3-1,4-beta-glucan 4-glucanohydrolase activity" EXACT [] +synonym: "1,3;1,4-beta-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.73] +synonym: "1,3;1,4-beta-glucan endohydrolase activity" RELATED [EC:3.2.1.73] +synonym: "beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.73] +synonym: "beta-glucanase activity" BROAD [EC:3.2.1.73] +synonym: "endo-beta-1,3-1,4 glucanase activity" RELATED [EC:3.2.1.73] +synonym: "lichenase activity" EXACT [] +synonym: "mixed linkage beta-glucanase activity" RELATED [EC:3.2.1.73] +xref: EC:3.2.1.73 +xref: MetaCyc:3.2.1.73-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0042973 +name: glucan endo-1,3-beta-D-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans." [EC:3.2.1.39] +synonym: "(1->3)-beta-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.39] +synonym: "(1->3)-beta-glucan endohydrolase activity" RELATED [EC:3.2.1.39] +synonym: "1,3-beta-D-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.39] +synonym: "1,3-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.39] +synonym: "beta-1,3-glucanase" BROAD [EC:3.2.1.39] +synonym: "callase activity" RELATED [EC:3.2.1.39] +synonym: "endo-(1,3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] +synonym: "endo-(1->3)-beta-D-glucanase activity" BROAD [EC:3.2.1.39] +synonym: "endo-1,3-beta-D-glucanase" BROAD [EC:3.2.1.39] +synonym: "endo-1,3-beta-glucanase activity" BROAD [] +synonym: "endo-1,3-beta-glucosidase activity" BROAD [EC:3.2.1.39] +synonym: "kitalase activity" RELATED [EC:3.2.1.39] +synonym: "laminaranase activity" BROAD [] +synonym: "laminarinase activity" BROAD [] +synonym: "oligo-1,3-glucosidase activity" RELATED [EC:3.2.1.39] +xref: EC:3.2.1.39 +xref: MetaCyc:3.2.1.39-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0042974 +name: retinoic acid receptor binding +namespace: molecular_function +def: "Binding to a retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796] +synonym: "RAR binding" EXACT [] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0042975 +name: peroxisome proliferator activated receptor binding +namespace: molecular_function +def: "Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma." [GOC:jl, PMID:12769781] +synonym: "PPAR binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0042976 +name: activation of Janus kinase activity +namespace: biological_process +alt_id: GO:0010531 +alt_id: GO:0042977 +def: "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803] +synonym: "activation of JAK protein" EXACT [GOC:dph, GOC:tb] +synonym: "activation of JAK protein by tyrosine phosphorylation" EXACT [] +synonym: "activation of JAK1 kinase activity" NARROW [] +synonym: "activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "activation of JAK2 kinase activity" NARROW [] +synonym: "activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of JAK protein activity by tyrosine phosphorylation" EXACT [] +synonym: "tyrosine phosphorylation of JAK protein" EXACT [] +synonym: "tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] +synonym: "tyrosine phosphorylation of JAK2 protein" NARROW [] +is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation +is_a: GO:0032147 ! activation of protein kinase activity +relationship: part_of GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0042978 +name: ornithine decarboxylase activator activity +namespace: molecular_function +def: "Binds to and increases ornithine decarboxylase activity." [GOC:jl] +synonym: "L-ornithine carboxy-lyase activator activity" NARROW [] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0042979 ! ornithine decarboxylase regulator activity + +[Term] +id: GO:0042979 +name: ornithine decarboxylase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of the enzyme ornithine decarboxylase." [GOC:jl] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0042980 +name: obsolete cystic fibrosis transmembrane conductance regulator binding +namespace: molecular_function +def: "OBSOLETE. Binding to a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "CFTR binding" EXACT [] +synonym: "cystic fibrosis transmembrane conductance regulator binding" EXACT [] +is_obsolete: true +replaced_by: GO:0044325 + +[Term] +id: GO:0042981 +name: regulation of apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] +comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. +synonym: "apoptosis regulator activity" RELATED [] +synonym: "regulation of apoptosis" NARROW [] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0006915 ! apoptotic process + +[Term] +id: GO:0042982 +name: amyloid precursor protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +synonym: "amyloid precursor protein metabolism" EXACT [] +synonym: "APP metabolic process" EXACT [] +synonym: "APP metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:0042983 +name: amyloid precursor protein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +synonym: "amyloid precursor protein anabolism" EXACT [] +synonym: "amyloid precursor protein biosynthesis" EXACT [] +synonym: "amyloid precursor protein formation" EXACT [] +synonym: "amyloid precursor protein synthesis" EXACT [] +synonym: "APP biosynthesis" EXACT [] +synonym: "APP biosynthetic process" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:0042982 ! amyloid precursor protein metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0042984 +name: regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] +synonym: "regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "regulation of amyloid precursor protein formation" EXACT [] +synonym: "regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "regulation of APP biosynthesis" EXACT [] +synonym: "regulation of APP biosynthetic process" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042985 +name: negative regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] +synonym: "down regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "down-regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "downregulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "inhibition of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "negative regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "negative regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "negative regulation of amyloid precursor protein formation" EXACT [] +synonym: "negative regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "negative regulation of APP biosynthesis" EXACT [] +synonym: "negative regulation of APP biosynthetic process" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process +relationship: negatively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042986 +name: positive regulation of amyloid precursor protein biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta." [GOC:go_curators] +synonym: "activation of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "positive regulation of amyloid precursor protein anabolism" EXACT [] +synonym: "positive regulation of amyloid precursor protein biosynthesis" EXACT [] +synonym: "positive regulation of amyloid precursor protein formation" EXACT [] +synonym: "positive regulation of amyloid precursor protein synthesis" EXACT [] +synonym: "positive regulation of APP biosynthesis" EXACT [] +synonym: "positive regulation of APP biosynthetic process" EXACT [] +synonym: "stimulation of amyloid precursor protein biosynthetic process" NARROW [] +synonym: "up regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "up-regulation of amyloid precursor protein biosynthetic process" EXACT [] +synonym: "upregulation of amyloid precursor protein biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0042984 ! regulation of amyloid precursor protein biosynthetic process +relationship: positively_regulates GO:0042983 ! amyloid precursor protein biosynthetic process + +[Term] +id: GO:0042987 +name: amyloid precursor protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators] +synonym: "amyloid precursor protein breakdown" EXACT [] +synonym: "amyloid precursor protein catabolism" EXACT [] +synonym: "amyloid precursor protein degradation" EXACT [] +synonym: "APP catabolic process" EXACT [] +synonym: "APP catabolism" EXACT [] +is_a: GO:0042982 ! amyloid precursor protein metabolic process + +[Term] +id: GO:0042988 +name: X11-like protein binding +namespace: molecular_function +def: "Binding to X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348] +synonym: "X11L binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0042989 +name: sequestering of actin monomers +namespace: biological_process +def: "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators] +synonym: "actin monomer retention" EXACT [] +synonym: "actin monomer sequestering" EXACT [] +synonym: "actin monomer sequestering activity" RELATED [] +synonym: "actin monomer sequestration" EXACT [] +synonym: "actin monomer storage" EXACT [] +synonym: "retention of actin monomers" EXACT [] +synonym: "sequestration of actin monomers" EXACT [] +synonym: "storage of actin monomers" EXACT [] +is_a: GO:0030837 ! negative regulation of actin filament polymerization +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0042990 +name: obsolete regulation of transcription factor import into nucleus +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. +synonym: "regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of transcription factor-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0042306 + +[Term] +id: GO:0042991 +name: obsolete transcription factor import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. +synonym: "transcription factor import into cell nucleus" EXACT [] +synonym: "transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "transcription factor-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0042992 +name: obsolete negative regulation of transcription factor import into nucleus +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. +synonym: "down regulation of transcription factor import into nucleus" EXACT [] +synonym: "down-regulation of transcription factor import into nucleus" EXACT [] +synonym: "downregulation of transcription factor import into nucleus" EXACT [] +synonym: "inhibition of transcription factor import into nucleus" NARROW [] +synonym: "negative regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "negative regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of transcription factor-nucleus import" EXACT [] +is_obsolete: true +consider: GO:0042308 + +[Term] +id: GO:0042993 +name: obsolete positive regulation of transcription factor import into nucleus +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl] +comment: The reason for obsoletion is that there is no distinct pathway to import transcription factors into the nucleus. +synonym: "activation of transcription factor import into nucleus" NARROW [] +synonym: "positive regulation of transcription factor import into cell nucleus" EXACT [] +synonym: "positive regulation of transcription factor transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of transcription factor-nucleus import" EXACT [] +synonym: "stimulation of transcription factor import into nucleus" NARROW [] +synonym: "up regulation of transcription factor import into nucleus" EXACT [] +synonym: "up-regulation of transcription factor import into nucleus" EXACT [] +synonym: "upregulation of transcription factor import into nucleus" EXACT [] +is_obsolete: true +consider: GO:0042307 + +[Term] +id: GO:0042994 +name: cytoplasmic sequestering of transcription factor +namespace: biological_process +def: "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] +synonym: "cytoplasmic retention of transcription factor" EXACT [] +synonym: "cytoplasmic sequestration of transcription factor" EXACT [] +synonym: "cytoplasmic storage of transcription factor" EXACT [] +synonym: "maintenance of transcription factor protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of transcription factor in cytoplasm" EXACT [] +synonym: "sequestering of transcription factor in cytoplasm" EXACT [] +synonym: "sequestration of transcription factor in cytoplasm" EXACT [] +synonym: "storage of transcription factor in cytoplasm" EXACT [] +synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] +is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity +is_a: GO:0051220 ! cytoplasmic sequestering of protein + +[Term] +id: GO:0042995 +name: cell projection +namespace: cellular_component +def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +subset: goslim_agr +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +synonym: "cell process" BROAD [] +synonym: "cellular process" BROAD [] +synonym: "cellular projection" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0042996 +name: regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:0060627 ! regulation of vesicle-mediated transport +is_a: GO:1903076 ! regulation of protein localization to plasma membrane +relationship: regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042997 +name: negative regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +synonym: "down regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "down-regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "downregulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "inhibition of Golgi to plasma membrane protein transport" NARROW [] +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +is_a: GO:0051224 ! negative regulation of protein transport +is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane +relationship: negatively_regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042998 +name: positive regulation of Golgi to plasma membrane protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl] +synonym: "activation of Golgi to plasma membrane protein transport" NARROW [] +synonym: "stimulation of Golgi to plasma membrane protein transport" NARROW [] +synonym: "up regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "up-regulation of Golgi to plasma membrane protein transport" EXACT [] +synonym: "upregulation of Golgi to plasma membrane protein transport" EXACT [] +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +is_a: GO:0051222 ! positive regulation of protein transport +is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane +relationship: positively_regulates GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0042999 +name: regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +is_a: GO:0042996 ! regulation of Golgi to plasma membrane protein transport +relationship: regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043000 +name: Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport" EXACT [] +is_a: GO:0043001 ! Golgi to plasma membrane protein transport + +[Term] +id: GO:0043001 +name: Golgi to plasma membrane protein transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363] +is_a: GO:0006893 ! Golgi to plasma membrane transport +is_a: GO:0015031 ! protein transport +is_a: GO:0061951 ! establishment of protein localization to plasma membrane + +[Term] +id: GO:0043002 +name: negative regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "down regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "down-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "downregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "inhibition of Golgi to plasma membrane CFTR protein transport" NARROW [] +is_a: GO:0042997 ! negative regulation of Golgi to plasma membrane protein transport +is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport +relationship: negatively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043003 +name: positive regulation of Golgi to plasma membrane CFTR protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl] +synonym: "activation of Golgi to plasma membrane CFTR protein transport" NARROW [] +synonym: "stimulation of Golgi to plasma membrane CFTR protein transport" NARROW [] +synonym: "up regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "up-regulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +synonym: "upregulation of Golgi to plasma membrane CFTR protein transport" EXACT [] +is_a: GO:0042998 ! positive regulation of Golgi to plasma membrane protein transport +is_a: GO:0042999 ! regulation of Golgi to plasma membrane CFTR protein transport +relationship: positively_regulates GO:0043000 ! Golgi to plasma membrane CFTR protein transport + +[Term] +id: GO:0043004 +name: cytoplasmic sequestering of CFTR protein +namespace: biological_process +def: "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl] +synonym: "cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] +synonym: "cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein" EXACT [] +synonym: "cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)" EXACT [] +synonym: "cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein" EXACT [] +synonym: "maintenance of CFTR protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] +synonym: "sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] +synonym: "sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm" EXACT [] +synonym: "storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm" EXACT [] +is_a: GO:0043002 ! negative regulation of Golgi to plasma membrane CFTR protein transport +is_a: GO:0051220 ! cytoplasmic sequestering of protein + +[Term] +id: GO:0043005 +name: neuron projection +namespace: cellular_component +def: "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] +subset: goslim_pir +synonym: "nerve fiber" RELATED [GOC:dph] +synonym: "neurite" NARROW [] +synonym: "neuron process" EXACT [] +synonym: "neuron protrusion" EXACT [NIF_Subcellular:sao250931889] +synonym: "neuronal cell projection" EXACT [] +xref: NIF_Subcellular:sao867568886 +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0043006 +name: activation of phospholipase A2 activity by calcium-mediated signaling +namespace: biological_process +def: "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb] +synonym: "activation of phospholipase A2 activity by calcium-mediated signalling" EXACT [GOC:mah] +synonym: "calcium-dependent activation of phospholipase A2" EXACT [GOC:dph, GOC:tb] +synonym: "calcium-dependent phospholipase A2 activation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0032431 ! activation of phospholipase A2 activity + +[Term] +id: GO:0043007 +name: maintenance of rDNA +namespace: biological_process +def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010] +synonym: "rDNA maintenance" EXACT [] +synonym: "ribosomal DNA maintenance" EXACT [] +is_a: GO:0043570 ! maintenance of DNA repeat elements + +[Term] +id: GO:0043008 +name: ATP-dependent protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex using energy from ATP hydrolysis." [GOC:jl] +subset: goslim_chembl +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043009 +name: chordate embryonic development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu] +is_a: GO:0009792 ! embryo development ending in birth or egg hatching + +[Term] +id: GO:0043010 +name: camera-type eye development +namespace: biological_process +alt_id: GO:0001747 +alt_id: GO:0031075 +def: "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0043011 +name: myeloid dendritic cell differentiation +namespace: biological_process +def: "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl] +xref: Wikipedia:Dendritic_cell +is_a: GO:0001773 ! myeloid dendritic cell activation +is_a: GO:0002573 ! myeloid leukocyte differentiation +is_a: GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:0043012 +name: regulation of fusion of sperm to egg plasma membrane +namespace: biological_process +def: "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, PMID:11483596] +synonym: "regulation of sperm-oocyte fusion" NARROW [] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:1903729 ! regulation of plasma membrane organization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization + +[Term] +id: GO:0043013 +name: negative regulation of fusion of sperm to egg plasma membrane +namespace: biological_process +def: "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] +synonym: "down regulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "down-regulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "downregulation of fusion of sperm to egg plasma membrane" EXACT [] +synonym: "inhibition of fusion of sperm to egg plasma membrane" NARROW [] +synonym: "inhibition of sperm-oocyte fusion" NARROW [] +synonym: "negative regulation of sperm-oocyte fusion" NARROW [] +is_a: GO:0043012 ! regulation of fusion of sperm to egg plasma membrane +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007342 ! fusion of sperm to egg plasma membrane involved in single fertilization + +[Term] +id: GO:0043014 +name: alpha-tubulin binding +namespace: molecular_function +def: "Binding to the microtubule constituent protein alpha-tubulin." [GOC:jl] +synonym: "alpha tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0043015 +name: gamma-tubulin binding +namespace: molecular_function +def: "Binding to the microtubule constituent protein gamma-tubulin." [GOC:jl] +synonym: "gamma tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0043020 +name: NADPH oxidase complex +namespace: cellular_component +def: "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767] +synonym: "flavocytochrome b558" NARROW [] +synonym: "respiratory-burst oxidase" RELATED [] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0043021 +name: ribonucleoprotein complex binding +namespace: molecular_function +def: "Binding to a complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] +subset: goslim_pir +synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk] +synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk] +synonym: "RNP binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0043022 +name: ribosome binding +namespace: molecular_function +alt_id: GO:0030376 +def: "Binding to a ribosome." [GOC:go_curators] +synonym: "ribosome receptor activity" NARROW [] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0043023 +name: ribosomal large subunit binding +namespace: molecular_function +def: "Binding to a large ribosomal subunit." [GOC:go_curators] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0043024 +name: ribosomal small subunit binding +namespace: molecular_function +def: "Binding to a small ribosomal subunit." [GOC:go_curators] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0043025 +name: neuronal cell body +namespace: cellular_component +def: "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators] +comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. +subset: goslim_pir +synonym: "neuron cell body" EXACT [] +synonym: "neuronal cell soma" EXACT [] +xref: NIF_Subcellular:sao1044911821 +xref: Wikipedia:Soma_(biology) +is_a: GO:0044297 ! cell body +relationship: part_of GO:0036477 ! somatodendritic compartment + +[Term] +id: GO:0043027 +name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] +synonym: "caspase inhibitor activity" BROAD [] +is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity +is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process + +[Term] +id: GO:0043028 +name: cysteine-type endopeptidase regulator activity involved in apoptotic process +namespace: molecular_function +def: "Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase] +synonym: "caspase regulator activity" BROAD [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0043029 +name: T cell homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149] +comment: Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. +synonym: "T lymphocyte homeostasis" EXACT [] +synonym: "T-cell homeostasis" EXACT [] +synonym: "T-lymphocyte homeostasis" EXACT [] +is_a: GO:0002260 ! lymphocyte homeostasis + +[Term] +id: GO:0043030 +name: regulation of macrophage activation +namespace: biological_process +def: "Any process that modulates the frequency or rate of macrophage activation." [GOC:jl] +synonym: "regulation of macrophage polarization" EXACT [] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043031 +name: negative regulation of macrophage activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl] +synonym: "down regulation of macrophage activation" EXACT [] +synonym: "down-regulation of macrophage activation" EXACT [] +synonym: "downregulation of macrophage activation" EXACT [] +synonym: "inhibition of macrophage activation" NARROW [] +synonym: "negative regulation of macrophage polarization" EXACT [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0043030 ! regulation of macrophage activation +relationship: negatively_regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043032 +name: positive regulation of macrophage activation +namespace: biological_process +def: "Any process that stimulates, induces or increases the rate of macrophage activation." [GOC:jl] +synonym: "activation of macrophage activation" NARROW [] +synonym: "positive regulation of macrophage polarization" EXACT [] +synonym: "stimulation of macrophage activation" NARROW [] +synonym: "up regulation of macrophage activation" EXACT [] +synonym: "up-regulation of macrophage activation" EXACT [] +synonym: "upregulation of macrophage activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0043030 ! regulation of macrophage activation +relationship: positively_regulates GO:0042116 ! macrophage activation + +[Term] +id: GO:0043033 +name: isoamylase complex +namespace: cellular_component +def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591] +subset: goslim_pir +synonym: "debranching enzyme complex" BROAD [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0043034 +name: costamere +namespace: cellular_component +def: "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378] +xref: Wikipedia:Costamere +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030016 ! myofibril + +[Term] +id: GO:0043035 +name: chromatin insulator sequence binding +namespace: molecular_function +def: "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795] +is_a: GO:0031490 ! chromatin DNA binding + +[Term] +id: GO:0043036 +name: starch grain +namespace: cellular_component +def: "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] +synonym: "starch granule" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:0043038 +name: amino acid activation +namespace: biological_process +def: "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl] +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0043039 +name: tRNA aminoacylation +namespace: biological_process +def: "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs] +synonym: "aminoacyl-tRNA biosynthesis" EXACT [GOC:mah] +synonym: "aminoacyl-tRNA biosynthetic process" EXACT [GOC:mah] +synonym: "tRNA charging" EXACT [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0043038 ! amino acid activation + +[Term] +id: GO:0043040 +name: tRNA aminoacylation for nonribosomal peptide biosynthetic process +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl] +synonym: "tRNA aminoacylation for nonribosomal peptide anabolism" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide biosynthesis" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide formation" EXACT [] +synonym: "tRNA aminoacylation for nonribosomal peptide synthesis" EXACT [] +is_a: GO:0043039 ! tRNA aminoacylation +is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043041 +name: amino acid activation for nonribosomal peptide biosynthetic process +namespace: biological_process +def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process." [GOC:jl] +synonym: "nonribosomal amino acid activation" RELATED [] +is_a: GO:0043038 ! amino acid activation +relationship: part_of GO:0019184 ! nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043042 +name: amino acid adenylylation by nonribosomal peptide synthase +namespace: biological_process +def: "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910] +synonym: "amino acid adenylation by nonribosomal peptide synthase" EXACT [] +synonym: "amino acid adenylation by NRPS" EXACT [] +is_a: GO:0043041 ! amino acid activation for nonribosomal peptide biosynthetic process + +[Term] +id: GO:0043043 +name: peptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [GOC:dph, GOC:jl] +synonym: "peptide anabolism" EXACT [] +synonym: "peptide biosynthesis" EXACT [] +synonym: "peptide formation" EXACT [] +synonym: "peptide synthesis" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0043045 +name: DNA methylation involved in embryo development +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111] +synonym: "de novo DNA methylation" RELATED [] +is_a: GO:0006306 ! DNA methylation +is_a: GO:1901538 ! changes to DNA methylation involved in embryo development + +[Term] +id: GO:0043046 +name: DNA methylation involved in gamete generation +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111] +synonym: "de novo DNA methylation" RELATED [] +is_a: GO:0006306 ! DNA methylation +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0043047 +name: single-stranded telomeric DNA binding +namespace: molecular_function +def: "Binding to single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] +synonym: "telomeric ssDNA binding" EXACT [GOC:mah] +is_a: GO:0042162 ! telomeric DNA binding +is_a: GO:0098847 ! sequence-specific single stranded DNA binding + +[Term] +id: GO:0043048 +name: dolichyl monophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl] +synonym: "dolichyl monophosphate anabolism" EXACT [] +synonym: "dolichyl monophosphate biosynthesis" EXACT [] +synonym: "dolichyl monophosphate formation" EXACT [] +synonym: "dolichyl monophosphate synthesis" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0043049 +name: otic placode formation +namespace: biological_process +def: "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0030916 ! otic vesicle formation + +[Term] +id: GO:0043050 +name: pharyngeal pumping +namespace: biological_process +def: "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052] +synonym: "pumping behavior" RELATED [] +is_a: GO:0042755 ! eating behavior + +[Term] +id: GO:0043051 +name: regulation of pharyngeal pumping +namespace: biological_process +def: "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052] +is_a: GO:1903998 ! regulation of eating behavior +relationship: regulates GO:0043050 ! pharyngeal pumping + +[Term] +id: GO:0043052 +name: thermotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467] +synonym: "taxis in response to temperature stimulus" EXACT [] +xref: Wikipedia:Thermotaxis +is_a: GO:0009266 ! response to temperature stimulus +is_a: GO:0042330 ! taxis + +[Term] +id: GO:0043053 +name: dauer entry +namespace: biological_process +def: "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, GOC:kmv, PMID:10077613] +synonym: "nematode entry into dormancy" EXACT [] +is_a: GO:0055115 ! entry into diapause +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043054 +name: dauer exit +namespace: biological_process +def: "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986] +synonym: "exit from nematode dormancy" EXACT [] +is_a: GO:0071981 ! exit from diapause +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043055 +name: maintenance of dauer +namespace: biological_process +def: "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740] +synonym: "maintenance of dormancy in the nematode" EXACT [] +is_a: GO:0071982 ! maintenance of diapause +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:0043056 +name: forward locomotion +namespace: biological_process +def: "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators] +is_a: GO:0033058 ! directional locomotion + +[Term] +id: GO:0043057 +name: backward locomotion +namespace: biological_process +def: "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators] +is_a: GO:0033058 ! directional locomotion + +[Term] +id: GO:0043058 +name: regulation of backward locomotion +namespace: biological_process +def: "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators] +is_a: GO:0040012 ! regulation of locomotion +relationship: regulates GO:0043057 ! backward locomotion + +[Term] +id: GO:0043059 +name: regulation of forward locomotion +namespace: biological_process +def: "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators] +is_a: GO:0040012 ! regulation of locomotion +relationship: regulates GO:0043056 ! forward locomotion + +[Term] +id: GO:0043060 +name: meiotic metaphase I plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] +is_a: GO:0051311 ! meiotic metaphase plate congression +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0043061 +name: meiotic metaphase II plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666] +is_a: GO:0051311 ! meiotic metaphase plate congression +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0043062 +name: extracellular structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "extracellular structure organisation" EXACT [] +synonym: "extracellular structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043063 +name: intercellular bridge organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid] +synonym: "intercellular bridge organisation" EXACT [] +synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0043062 ! extracellular structure organization + +[Term] +id: GO:0043064 +name: obsolete flagellum organization +namespace: biological_process +def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "flagellum organisation" EXACT [] +synonym: "flagellum organization" EXACT [] +synonym: "flagellum organization and biogenesis" RELATED [GOC:mah] +is_obsolete: true +consider: GO:0044781 +consider: GO:0044782 + +[Term] +id: GO:0043065 +name: positive regulation of apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] +comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. +subset: goslim_chembl +synonym: "activation of apoptosis" NARROW [] +synonym: "positive regulation of apoptosis" NARROW [] +synonym: "pro-apoptosis" RELATED [] +synonym: "stimulation of apoptosis" NARROW [] +synonym: "up regulation of apoptosis" EXACT [] +synonym: "up-regulation of apoptosis" EXACT [] +synonym: "upregulation of apoptosis" EXACT [] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:0043068 ! positive regulation of programmed cell death +relationship: positively_regulates GO:0006915 ! apoptotic process + +[Term] +id: GO:0043066 +name: negative regulation of apoptotic process +namespace: biological_process +alt_id: GO:0006916 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] +comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. +synonym: "anti-apoptosis" EXACT [] +synonym: "apoptosis inhibitor activity" RELATED [] +synonym: "down regulation of apoptosis" EXACT [] +synonym: "down-regulation of apoptosis" EXACT [] +synonym: "downregulation of apoptosis" EXACT [] +synonym: "inhibition of apoptosis" NARROW [] +synonym: "negative regulation of apoptosis" NARROW [] +synonym: "pro-survival" RELATED [] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:0043069 ! negative regulation of programmed cell death +relationship: negatively_regulates GO:0006915 ! apoptotic process + +[Term] +id: GO:0043067 +name: regulation of programmed cell death +namespace: biological_process +alt_id: GO:0043070 +def: "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +synonym: "regulation of non-apoptotic programmed cell death" NARROW [] +is_a: GO:0010941 ! regulation of cell death +relationship: regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043068 +name: positive regulation of programmed cell death +namespace: biological_process +alt_id: GO:0043071 +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +synonym: "activation of programmed cell death" NARROW [] +synonym: "positive regulation of non-apoptotic programmed cell death" NARROW [] +synonym: "stimulation of programmed cell death" NARROW [] +synonym: "up regulation of programmed cell death" EXACT [] +synonym: "up-regulation of programmed cell death" EXACT [] +synonym: "upregulation of programmed cell death" EXACT [] +is_a: GO:0010942 ! positive regulation of cell death +is_a: GO:0043067 ! regulation of programmed cell death +relationship: positively_regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043069 +name: negative regulation of programmed cell death +namespace: biological_process +alt_id: GO:0043072 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl] +synonym: "down regulation of programmed cell death" EXACT [] +synonym: "down-regulation of programmed cell death" EXACT [] +synonym: "downregulation of programmed cell death" EXACT [] +synonym: "inhibition of programmed cell death" NARROW [] +synonym: "negative regulation of non-apoptotic programmed cell death" NARROW [] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0060548 ! negative regulation of cell death +relationship: negatively_regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0043073 +name: germ cell nucleus +namespace: cellular_component +def: "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators] +synonym: "germ-cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0043075 +name: obsolete sperm cell nucleus (sensu Magnoliophyta) +namespace: cellular_component +def: "OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents." [GOC:jl] +comment: This term was made obsolete because the definition was incorrect. +synonym: "pollen germ cell nucleus" EXACT [] +synonym: "pollen germ-cell nucleus" EXACT [] +synonym: "sperm cell nucleus (sensu Magnoliophyta)" EXACT [] +is_obsolete: true +consider: GO:0048555 + +[Term] +id: GO:0043076 +name: megasporocyte nucleus +namespace: cellular_component +def: "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153] +synonym: "megaspore mother cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0043077 +name: initiation of acetate catabolic process +namespace: biological_process +def: "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl] +synonym: "initiation of acetate breakdown" EXACT [] +synonym: "initiation of acetate catabolism" EXACT [] +synonym: "initiation of acetate degradation" EXACT [] +is_a: GO:0045754 ! positive regulation of acetate catabolic process + +[Term] +id: GO:0043078 +name: polar nucleus +namespace: cellular_component +def: "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043079 +name: antipodal cell nucleus +namespace: cellular_component +def: "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043082 +name: megagametophyte egg cell nucleus +namespace: cellular_component +def: "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu] +is_a: GO:0043076 ! megasporocyte nucleus + +[Term] +id: GO:0043083 +name: synaptic cleft +namespace: cellular_component +def: "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm] +subset: goslim_synapse +xref: NIF_Subcellular:sao243541954 +is_a: GO:0005576 ! extracellular region + +[Term] +id: GO:0043084 +name: penile erection +namespace: biological_process +def: "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection] +xref: Wikipedia:Erection#Penile_erection +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007620 ! copulation + +[Term] +id: GO:0043085 +name: positive regulation of catalytic activity +namespace: biological_process +alt_id: GO:0048554 +def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] +subset: goslim_chembl +synonym: "activation of enzyme activity" NARROW [] +synonym: "activation of metalloenzyme activity" NARROW [] +synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] +synonym: "positive regulation of metalloenzyme activity" NARROW [] +synonym: "stimulation of enzyme activity" NARROW [] +synonym: "stimulation of metalloenzyme activity" NARROW [] +synonym: "up regulation of enzyme activity" EXACT [] +synonym: "up regulation of metalloenzyme activity" NARROW [] +synonym: "up-regulation of enzyme activity" EXACT [] +synonym: "up-regulation of metalloenzyme activity" NARROW [] +synonym: "upregulation of enzyme activity" EXACT [] +synonym: "upregulation of metalloenzyme activity" NARROW [] +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0043086 +name: negative regulation of catalytic activity +namespace: biological_process +alt_id: GO:0048553 +def: "Any process that stops or reduces the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] +synonym: "down regulation of enzyme activity" EXACT [] +synonym: "down regulation of metalloenzyme activity" NARROW [] +synonym: "down-regulation of enzyme activity" EXACT [] +synonym: "down-regulation of metalloenzyme activity" EXACT [] +synonym: "downregulation of enzyme activity" EXACT [] +synonym: "downregulation of metalloenzyme activity" NARROW [] +synonym: "inhibition of enzyme activity" NARROW [] +synonym: "inhibition of metalloenzyme activity" NARROW [] +synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] +synonym: "negative regulation of metalloenzyme activity" NARROW [] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0043087 +name: regulation of GTPase activity +namespace: biological_process +alt_id: GO:0032312 +alt_id: GO:0032313 +alt_id: GO:0032314 +alt_id: GO:0032315 +alt_id: GO:0032316 +alt_id: GO:0032317 +alt_id: GO:0032318 +alt_id: GO:0032319 +alt_id: GO:0043088 +def: "Any process that modulates the rate of GTP hydrolysis by a GTPase." [GOC:jl, GOC:mah] +synonym: "regulation of ARF GTPase activity" NARROW [] +synonym: "regulation of Cdc42 GTPase activity" NARROW [] +synonym: "regulation of Rab GTPase activity" NARROW [] +synonym: "regulation of Rac GTPase activity" NARROW [] +synonym: "regulation of Ral GTPase activity" NARROW [] +synonym: "regulation of Ran GTPase activity" NARROW [] +synonym: "regulation of Rap GTPase activity" NARROW [] +synonym: "regulation of Ras GTPase activity" NARROW [] +synonym: "regulation of Rho GTPase activity" NARROW [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043090 +name: amino acid import +namespace: biological_process +def: "The directed movement of amino acids into a cell or organelle." [GOC:jl] +synonym: "amino acid uptake" EXACT [] +is_a: GO:0006865 ! amino acid transport + +[Term] +id: GO:0043093 +name: FtsZ-dependent cytokinesis +namespace: biological_process +def: "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells." [GOC:mah, ISBN:0815108893, PMID:12626683] +comment: Note that this term is intended for the annotation of prokaryotic gene products. +synonym: "cytokinesis by binary fission" RELATED [GOC:dph] +synonym: "prokaryote-type cytokinesis" RELATED [GOC:mah] +synonym: "prokaryotic fission" RELATED [Wikipedia:Binary_fission] +xref: Wikipedia:Binary_fission +is_a: GO:0000910 ! cytokinesis +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0019954 ! asexual reproduction +relationship: part_of GO:0032505 ! reproduction of a single-celled organism + +[Term] +id: GO:0043094 +name: cellular metabolic compound salvage +namespace: biological_process +def: "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg] +subset: goslim_pir +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0043095 +name: regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0043096 +name: purine nucleobase salvage +namespace: biological_process +def: "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [GOC:jl] +synonym: "purine base salvage" EXACT [GOC:go_curators] +is_a: GO:0009113 ! purine nucleobase biosynthetic process +is_a: GO:0043101 ! purine-containing compound salvage + +[Term] +id: GO:0043097 +name: pyrimidine nucleoside salvage +namespace: biological_process +def: "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0008655 ! pyrimidine-containing compound salvage +is_a: GO:0043174 ! nucleoside salvage +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process + +[Term] +id: GO:0043098 +name: purine deoxyribonucleoside salvage +namespace: biological_process +def: "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0043101 ! purine-containing compound salvage +is_a: GO:0043174 ! nucleoside salvage +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0043099 +name: pyrimidine deoxyribonucleoside salvage +namespace: biological_process +def: "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0043097 ! pyrimidine nucleoside salvage +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0043100 +name: pyrimidine nucleobase salvage +namespace: biological_process +def: "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [GOC:jl] +synonym: "pyrimidine base salvage" EXACT [GOC:go_curators] +is_a: GO:0008655 ! pyrimidine-containing compound salvage + +[Term] +id: GO:0043101 +name: purine-containing compound salvage +namespace: biological_process +def: "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [GOC:jl] +subset: goslim_pir +synonym: "purine salvage" RELATED [] +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage +is_a: GO:0072522 ! purine-containing compound biosynthetic process + +[Term] +id: GO:0043102 +name: amino acid salvage +namespace: biological_process +def: "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043103 +name: hypoxanthine salvage +namespace: biological_process +def: "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732] +synonym: "adenine, hypoxanthine and their nucleoside salvage" NARROW [] +synonym: "guanine, xanthine and their nucleoside salvage" NARROW [] +is_a: GO:0043096 ! purine nucleobase salvage +is_a: GO:0046101 ! hypoxanthine biosynthetic process + +[Term] +id: GO:0043104 +name: positive regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +synonym: "activation of GTP cyclohydrolase I activity" NARROW [] +synonym: "stimulation of GTP cyclohydrolase I activity" NARROW [] +synonym: "up regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "up-regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "upregulation of GTP cyclohydrolase I activity" EXACT [] +is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0043105 +name: negative regulation of GTP cyclohydrolase I activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." [GOC:jl] +synonym: "down regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "down-regulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "downregulation of GTP cyclohydrolase I activity" EXACT [] +synonym: "inhibition of GTP cyclohydrolase I activity" NARROW [] +is_a: GO:0043095 ! regulation of GTP cyclohydrolase I activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0043107 +name: type IV pilus-dependent motility +namespace: biological_process +def: "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238] +synonym: "social gliding motility" NARROW [] +synonym: "TFP-dependent motility" EXACT [] +synonym: "TFP-dependent movement" EXACT [] +synonym: "twitching motility" NARROW [] +synonym: "type 4 pilus-dependent motility" EXACT [] +synonym: "type four pilus-dependent motility" EXACT [] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0043108 +name: pilus retraction +namespace: biological_process +def: "The process of withdrawing a pilus back into a cell." [GOC:go_curators, PMID:17355871] +is_a: GO:0043711 ! pilus organization + +[Term] +id: GO:0043110 +name: rDNA spacer replication fork barrier binding +namespace: molecular_function +def: "Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529] +synonym: "RFB binding" EXACT [] +is_a: GO:0000182 ! rDNA binding +is_a: GO:0031634 ! replication fork barrier binding + +[Term] +id: GO:0043111 +name: replication fork arrest +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected." [GOC:jl, GOC:pr, PMID:14645529] +comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. +synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb] +synonym: "replication fork blocking" EXACT [] +synonym: "replication fork stalling" EXACT [] +is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication + +[Term] +id: GO:0043112 +name: receptor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl] +synonym: "receptor metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0043113 +name: receptor clustering +namespace: biological_process +def: "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460] +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:0043114 +name: regulation of vascular permeability +namespace: biological_process +def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0043115 +name: precorrin-2 dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15613] +synonym: "1,3-dimethyluroporphyrinogen III dehydrogenase activity" EXACT [] +synonym: "CysG" RELATED [EC:1.3.1.76] +synonym: "dihydrosirohydrochlorin dehydrogenase activity" EXACT [] +synonym: "Met8p" RELATED [EC:1.3.1.76] +synonym: "precorrin-2 oxidase activity" RELATED [EC:1.3.1.76] +synonym: "precorrin-2:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.76] +synonym: "SirC" RELATED [EC:1.3.1.76] +synonym: "siroheme synthase activity" BROAD [] +xref: EC:1.3.1.76 +xref: KEGG_REACTION:R03947 +xref: MetaCyc:DIMETHUROPORDEHYDROG-RXN +xref: RHEA:15613 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043116 +name: negative regulation of vascular permeability +namespace: biological_process +def: "Any process that reduces the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +synonym: "down regulation of vascular permeability" EXACT [] +synonym: "down-regulation of vascular permeability" EXACT [] +synonym: "downregulation of vascular permeability" EXACT [] +synonym: "inhibition of vascular permeability" NARROW [] +is_a: GO:0043114 ! regulation of vascular permeability + +[Term] +id: GO:0043117 +name: positive regulation of vascular permeability +namespace: biological_process +def: "Any process that increases the extent to which blood vessels can be pervaded by fluid." [GOC:jl] +synonym: "activation of vascular permeability" NARROW [] +synonym: "stimulation of vascular permeability" NARROW [] +synonym: "up regulation of vascular permeability" EXACT [] +synonym: "up-regulation of vascular permeability" EXACT [] +synonym: "upregulation of vascular permeability" EXACT [] +is_a: GO:0043114 ! regulation of vascular permeability + +[Term] +id: GO:0043120 +name: tumor necrosis factor binding +namespace: molecular_function +def: "Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0043121 +name: neurotrophin binding +namespace: molecular_function +alt_id: GO:0048404 +alt_id: GO:0048405 +def: "Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl] +comment: Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. +synonym: "neurotrophic factor binding" EXACT [GOC:aruk, GOC:bc] +synonym: "neurotrophin 3 binding" NARROW [] +synonym: "neurotrophin 4/5 binding" NARROW [] +synonym: "neurotrophin TRK receptor activity" RELATED [] +synonym: "neurotrophin TRKA receptor activity" RELATED [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +synonym: "neurotrophin TRKC receptor activity" RELATED [] +synonym: "neurotrophin-3 binding" NARROW [] +synonym: "neurotrophin-4/5 binding" NARROW [] +synonym: "NT 4/5 binding" NARROW [] +synonym: "NT-3 binding" NARROW [] +synonym: "NT-4 binding" NARROW [] +synonym: "NT-4/5 binding" NARROW [] +synonym: "NT-5 binding" NARROW [] +synonym: "NT3 binding" NARROW [] +synonym: "NT4 binding" NARROW [] +synonym: "NT5 binding" NARROW [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0043122 +name: regulation of I-kappaB kinase/NF-kappaB signaling +namespace: biological_process +def: "Any process that modulates I-kappaB kinase/NF-kappaB signaling." [GOC:jl, PMID:12773372] +synonym: "regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling + +[Term] +id: GO:0043123 +name: positive regulation of I-kappaB kinase/NF-kappaB signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl] +synonym: "activation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "positive regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "stimulation of I-kappaB kinase/NF-kappaB cascade" NARROW [] +synonym: "up regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "up-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "upregulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling + +[Term] +id: GO:0043124 +name: negative regulation of I-kappaB kinase/NF-kappaB signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling." [GOC:jl] +synonym: "down regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "down-regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "downregulation of I-kappaB kinase/NF-kappaB cascade" RELATED [] +synonym: "inhibition of I-kappaB kinase/NF-kappaB cascade" NARROW [] +synonym: "negative regulation of I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] +is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0007249 ! I-kappaB kinase/NF-kappaB signaling + +[Term] +id: GO:0043125 +name: ErbB-3 class receptor binding +namespace: molecular_function +def: "Binding to the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl] +synonym: "HER3 receptor binding" EXACT [] +synonym: "Neu/ErbB-2 receptor activity" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0043126 +name: regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] +synonym: "regulation of PI4K activity" EXACT [] +is_a: GO:0043550 ! regulation of lipid kinase activity + +[Term] +id: GO:0043127 +name: negative regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl] +synonym: "down regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "down-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "downregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "inhibition of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "negative regulation of PI4K activity" EXACT [] +is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity +is_a: GO:0090219 ! negative regulation of lipid kinase activity + +[Term] +id: GO:0043128 +name: positive regulation of 1-phosphatidylinositol 4-kinase activity +namespace: biological_process +def: "Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase." [GOC:jl] +synonym: "activation of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "positive regulation of PI4K activity" EXACT [] +synonym: "stimulation of 1-phosphatidylinositol 4-kinase activity" NARROW [] +synonym: "up regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "up-regulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +synonym: "upregulation of 1-phosphatidylinositol 4-kinase activity" EXACT [] +is_a: GO:0043126 ! regulation of 1-phosphatidylinositol 4-kinase activity +is_a: GO:0090218 ! positive regulation of lipid kinase activity + +[Term] +id: GO:0043129 +name: surfactant homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757] +is_a: GO:0048875 ! chemical homeostasis within a tissue + +[Term] +id: GO:0043130 +name: ubiquitin binding +namespace: molecular_function +def: "Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd] +xref: Reactome:R-HSA-1169404 "Transfer of ISG15 from E1 to E2 (UBCH8)" +xref: Reactome:R-HSA-205008 "Polyubiquitinated NRIF binds to p62 (Sequestosome)" +xref: Reactome:R-HSA-983152 "Transfer of ubiquitin from E1 to E2" +is_a: GO:0032182 ! ubiquitin-like protein binding + +[Term] +id: GO:0043131 +name: erythrocyte enucleation +namespace: biological_process +def: "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hjd] +is_a: GO:0090601 ! enucleation +relationship: part_of GO:0043354 ! enucleate erythrocyte maturation + +[Term] +id: GO:0043132 +name: NAD transport +namespace: biological_process +def: "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl] +synonym: "NAD (oxidized) transport" EXACT [] +synonym: "NAD (reduced) transport" EXACT [] +synonym: "NADH transport" EXACT [] +synonym: "nicotinamide adenine dinucleotide transport" EXACT [] +synonym: "oxidized NAD transport" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide transport" EXACT [] +synonym: "reduced NAD transport" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide transport" EXACT [] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0043133 +name: hindgut contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046] +is_a: GO:0006939 ! smooth muscle contraction +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0043134 +name: regulation of hindgut contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0044058 ! regulation of digestive system process +relationship: regulates GO:0043133 ! hindgut contraction + +[Term] +id: GO:0043135 +name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170] +synonym: "PRPP pyrophosphatase activity" EXACT [] +xref: MetaCyc:RXN-10969 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0043136 +name: glycerol-3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate." [GOC:jl] +xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN +xref: Reactome:R-HSA-8955794 "PGP:Mg2+ dimer hydrolyses 3PG to glycerol" +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043137 +name: DNA replication, removal of RNA primer +namespace: biological_process +def: "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238] +synonym: "Okazaki initiator RNA removal" EXACT [] +is_a: GO:0006401 ! RNA catabolic process +relationship: part_of GO:0006260 ! DNA replication + +[Term] +id: GO:0043138 +name: 3'-5' DNA helicase activity +namespace: molecular_function +alt_id: GO:0043140 +def: "Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis." [GOC:jl] +synonym: "3' to 5' DNA helicase activity" EXACT [] +synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] +synonym: "ATP-dependent 3'-5' DNA helicase activity" EXACT [] +xref: Reactome:R-HSA-167097 "HIV Promoter Opening: First Transition" +xref: Reactome:R-HSA-174438 "Formation of the Flap Intermediate on the C-strand" +xref: Reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition" +xref: Reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition" +xref: Reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition" +xref: Reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript" +xref: Reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript" +xref: Reactome:R-HSA-9684118 "ERCC3-facilitated RNA Pol II backtracking in TC-NER" +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0043139 +name: 5'-3' DNA helicase activity +namespace: molecular_function +alt_id: GO:0008722 +alt_id: GO:0043141 +def: "Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis." [GOC:jl] +synonym: "5' to 3' DNA helicase activity" EXACT [] +synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] +synonym: "ATP-dependent 5'-3' DNA helicase activity" EXACT [] +synonym: "DNA helicase IV activity" NARROW [] +xref: Reactome:R-HSA-6782131 "ERCC2-facilitated RNA Pol II backtracking in TC-NER" +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0043143 +name: regulation of translation by machinery localization +namespace: biological_process +def: "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl] +synonym: "establishment and maintenance of translational machinery localization" EXACT [] +synonym: "establishment and maintenance of translational protein localization" EXACT [] +synonym: "regulation of translation by machinery localisation" EXACT [GOC:mah] +synonym: "translational machinery localization" EXACT [GOC:dph, GOC:tb] +synonym: "translational protein localization" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0034613 ! cellular protein localization +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0043144 +name: sno(s)RNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea)." [GOC:go_curators, GOC:krc, PMID:12773397] +subset: goslim_yeast +is_a: GO:0016074 ! sno(s)RNA metabolic process +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0043145 +name: sno(s)RNA 3'-end cleavage +namespace: biological_process +def: "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397] +synonym: "sno(s)RNA 3' end cleavage" EXACT [] +synonym: "snoRNA 3'-end cleavage" NARROW [] +synonym: "sRNA 3'-end cleavage" NARROW [] +is_a: GO:0031126 ! sno(s)RNA 3'-end processing +is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic + +[Term] +id: GO:0043149 +name: stress fiber assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381] +synonym: "actin cable assembly" RELATED [GOC:mah] +synonym: "actin cable formation" RELATED [GOC:mah] +synonym: "stress fibre biosynthesis" RELATED [] +synonym: "stress fibre formation" RELATED [] +is_a: GO:0030038 ! contractile actin filament bundle assembly +is_a: GO:0031032 ! actomyosin structure organization + +[Term] +id: GO:0043150 +name: DNA synthesis involved in double-strand break repair via homologous recombination +namespace: biological_process +def: "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators] +synonym: "DNA synthesis during double-strand break repair via homologous recombination" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000731 ! DNA synthesis involved in DNA repair +relationship: part_of GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0043151 +name: DNA synthesis involved in double-strand break repair via single-strand annealing +namespace: biological_process +def: "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators] +synonym: "DNA synthesis during double-strand break repair via single-strand annealing" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000731 ! DNA synthesis involved in DNA repair +relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:0043152 +name: induction of bacterial agglutination +namespace: biological_process +def: "Any process in which infecting bacteria are clumped together by a host organism." [GOC:jl] +is_a: GO:0019731 ! antibacterial humoral response + +[Term] +id: GO:0043153 +name: entrainment of circadian clock by photoperiod +namespace: biological_process +def: "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl] +synonym: "photoentrainment of circadian clock" EXACT [PMID:10217146] +is_a: GO:0009648 ! photoperiodism +is_a: GO:0009649 ! entrainment of circadian clock + +[Term] +id: GO:0043154 +name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +alt_id: GO:0001719 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] +synonym: "down regulation of caspase activity" EXACT [] +synonym: "down-regulation of caspase activity" EXACT [] +synonym: "downregulation of caspase activity" EXACT [] +synonym: "inhibition of caspase activation" NARROW [] +synonym: "inhibition of caspase activity" NARROW [] +synonym: "negative regulation of caspase activation" EXACT [] +synonym: "negative regulation of caspase activity" BROAD [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:0043155 +name: negative regulation of photosynthesis, light reaction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl] +synonym: "down regulation of photosynthesis, light reaction" EXACT [] +synonym: "down-regulation of photosynthesis, light reaction" EXACT [] +synonym: "downregulation of photosynthesis, light reaction" EXACT [] +synonym: "inhibition of photosynthesis, light reaction" NARROW [] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction +is_a: GO:1905156 ! negative regulation of photosynthesis +relationship: negatively_regulates GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0043156 +name: obsolete chromatin remodeling in response to cation stress +namespace: biological_process +def: "OBSOLETE. Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0043157 +name: response to cation stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213] +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0043158 +name: heterocyst differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl] +synonym: "heterocyst biosynthesis" EXACT [] +synonym: "heterocyst cell differentiation" EXACT [] +synonym: "heterocyst formation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0043159 +name: acrosomal matrix +namespace: cellular_component +def: "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0001669 ! acrosomal vesicle +relationship: part_of GO:0005773 ! vacuole + +[Term] +id: GO:0043160 +name: acrosomal lumen +namespace: cellular_component +def: "The volume enclosed within the acrosome membrane." [GOC:go_curators] +is_a: GO:0034774 ! secretory granule lumen +is_a: GO:0043202 ! lysosomal lumen +relationship: part_of GO:0001669 ! acrosomal vesicle + +[Term] +id: GO:0043161 +name: proteasome-mediated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] +synonym: "proteasomal pathway" EXACT [] +synonym: "proteasomal processing" RELATED [] +synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT [] +synonym: "proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT [] +synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT [] +synonym: "proteasome pathway" RELATED [] +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process +is_a: GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0043162 +name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] +synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT [] +synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT [] +is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0043163 +name: cell envelope organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl] +subset: goslim_pir +synonym: "cell envelope organisation" EXACT [] +synonym: "cell envelope organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0043164 +name: Gram-negative-bacterium-type cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893] +synonym: "1-2nm peptidoglycan-based cell wall biogenesis" EXACT [] +synonym: "cell wall anabolism" BROAD [] +synonym: "cell wall assembly" BROAD [] +synonym: "cell wall biosynthetic process" BROAD [] +synonym: "cell wall formation" BROAD [] +synonym: "cell wall synthesis" BROAD [] +is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0043165 +name: Gram-negative-bacterium-type cell outer membrane assembly +namespace: biological_process +def: "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254] +synonym: "cell outer membrane biogenesis" RELATED [GOC:mah] +is_a: GO:0071709 ! membrane assembly +relationship: part_of GO:0043163 ! cell envelope organization + +[Term] +id: GO:0043167 +name: ion binding +namespace: molecular_function +def: "Binding to an ion, a charged atoms or groups of atoms." [GOC:jl] +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_yeast +synonym: "atom binding" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043168 +name: anion binding +namespace: molecular_function +def: "Binding to an anion, a charged atom or group of atoms with a net negative charge." [GOC:jl] +is_a: GO:0043167 ! ion binding + +[Term] +id: GO:0043169 +name: cation binding +namespace: molecular_function +def: "Binding to a cation, a charged atom or group of atoms with a net positive charge." [GOC:jl] +is_a: GO:0043167 ! ion binding + +[Term] +id: GO:0043170 +name: macromolecule metabolic process +namespace: biological_process +alt_id: GO:0043283 +alt_id: GO:0044259 +def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:mah] +subset: goslim_pir +synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "macromolecule metabolism" EXACT [] +synonym: "multicellular organismal macromolecule metabolic process" NARROW [] +synonym: "organismal macromolecule metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0043171 +name: peptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl] +synonym: "peptide breakdown" EXACT [] +synonym: "peptide catabolism" EXACT [] +synonym: "peptide degradation" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0043172 +name: obsolete ferredoxin biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732] +comment: This term was made obsolete because it refers to biosynthesis of a protein. +synonym: "ferredoxin anabolism" EXACT [] +synonym: "ferredoxin biosynthesis" EXACT [] +synonym: "ferredoxin formation" EXACT [] +synonym: "ferredoxin synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043173 +name: nucleotide salvage +namespace: biological_process +def: "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl] +xref: Wikipedia:Nucleotide_salvage +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043174 +name: nucleoside salvage +namespace: biological_process +def: "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl] +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0043094 ! cellular metabolic compound salvage + +[Term] +id: GO:0043175 +name: RNA polymerase core enzyme binding +namespace: molecular_function +def: "Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH] +is_a: GO:0070063 ! RNA polymerase binding + +[Term] +id: GO:0043176 +name: amine binding +namespace: molecular_function +def: "Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group." [GOC:jl] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043177 +name: organic acid binding +namespace: molecular_function +def: "Binding to an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732] +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0043178 +name: alcohol binding +namespace: molecular_function +def: "Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732] +subset: goslim_pir +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0043179 +name: rhythmic excitation +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433] +is_a: GO:0060024 ! rhythmic synaptic transmission + +[Term] +id: GO:0043180 +name: rhythmic inhibition +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators] +is_a: GO:0060024 ! rhythmic synaptic transmission + +[Term] +id: GO:0043181 +name: vacuolar sequestering +namespace: biological_process +def: "The process of transporting a substance into, and confining within, a vacuole." [GOC:jl] +synonym: "retention in vacuole" EXACT [] +synonym: "sequestering in vacuole" EXACT [] +synonym: "sequestration in vacuole" EXACT [] +synonym: "storage in vacuole" EXACT [] +synonym: "vacuolar retention" EXACT [] +synonym: "vacuolar sequestration" EXACT [] +synonym: "vacuolar storage" EXACT [] +is_a: GO:0051651 ! maintenance of location in cell + +[Term] +id: GO:0043182 +name: vacuolar sequestering of sodium ion +namespace: biological_process +def: "The process of transporting sodium ions into, and confining within, a vacuole." [GOC:jl] +synonym: "sequestering of sodium ion (Na+) in vacuole" EXACT [] +synonym: "sequestration of sodium ion (Na+) in vacuole" EXACT [] +synonym: "sodium ion (Na+) retention in vacuole" EXACT [] +synonym: "sodium ion (Na+) storage in vacuole" EXACT [] +synonym: "vacuolar sequestering of sodium ion (Na+)" EXACT [] +synonym: "vacuolar sequestration of sodium ion (Na+)" EXACT [] +synonym: "vacuolar sodium ion (Na+) retention" EXACT [] +synonym: "vacuolar sodium ion (Na+) storage" EXACT [] +is_a: GO:0043181 ! vacuolar sequestering +relationship: part_of GO:0006883 ! cellular sodium ion homeostasis + +[Term] +id: GO:0043183 +name: vascular endothelial growth factor receptor 1 binding +namespace: molecular_function +def: "Binding to a vascular endothelial growth factor receptor 1." [GOC:st] +synonym: "Flt-1 binding" EXACT [] +synonym: "VEGF receptor 1 binding" EXACT [] +synonym: "VEGFR 1 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043184 +name: vascular endothelial growth factor receptor 2 binding +namespace: molecular_function +def: "Binding to a vascular endothelial growth factor receptor 2." [GOC:st] +synonym: "Flk-1 binding" EXACT [] +synonym: "KDR binding" BROAD [] +synonym: "kinase domain region binding" EXACT [] +synonym: "VEGF receptor 2 binding" EXACT [] +synonym: "VEGFR 2 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043185 +name: vascular endothelial growth factor receptor 3 binding +namespace: molecular_function +def: "Binding to a vascular endothelial growth factor receptor 3." [GOC:st] +synonym: "fms-like-tyrosine kinase (Flt)-4 binding" EXACT [] +synonym: "VEGF receptor 3 binding" EXACT [] +synonym: "VEGFR 3 binding" EXACT [] +is_a: GO:0005172 ! vascular endothelial growth factor receptor binding + +[Term] +id: GO:0043186 +name: P granule +namespace: cellular_component +alt_id: GO:0018994 +def: "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230] +synonym: "germline granule" BROAD [] +synonym: "nuage" NARROW [] +synonym: "polar granule" NARROW [] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule +relationship: part_of GO:0060293 ! germ plasm + +[Term] +id: GO:0043188 +name: cell septum edging +namespace: cellular_component +def: "The cell wall material that surrounds the septum in fungal cells." [GOC:vw] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0043189 +name: H4/H2A histone acetyltransferase complex +namespace: cellular_component +def: "A multisubunit complex that catalyzes the acetylation of histones H4 and H2A." [GOC:mah, GOC:rb] +synonym: "H4/H2A HAT complex" EXACT [] +is_a: GO:1902562 ! H4 histone acetyltransferase complex + +[Term] +id: GO:0043190 +name: ATP-binding cassette (ABC) transporter complex +namespace: cellular_component +alt_id: GO:0043191 +alt_id: GO:0043192 +def: "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "ABC-type efflux permease complex" NARROW [] +synonym: "ABC-type efflux porter complex" NARROW [] +synonym: "ABC-type uptake permease complex" NARROW [] +synonym: "mating pheromone exporter" NARROW [] +is_a: GO:0098533 ! ATPase dependent transmembrane transport complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0043194 +name: axon initial segment +namespace: cellular_component +def: "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097] +synonym: "initial segment" EXACT [] +xref: NIF_Subcellular:sao256000789 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0043195 +name: terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967] +synonym: "bouton" EXACT [] +synonym: "presynaptic bouton" EXACT [] +synonym: "synaptic bouton" EXACT [NIF_Subcellular:sao187426937] +synonym: "terminal button" EXACT [] +xref: NIF_Subcellular:sao187426937 +is_a: GO:0098793 ! presynapse +relationship: part_of GO:0043679 ! axon terminus + +[Term] +id: GO:0043196 +name: varicosity +namespace: cellular_component +def: "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0043197 +name: dendritic spine +namespace: cellular_component +def: "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln] +subset: goslim_synapse +synonym: "branched dendritic spine" NARROW [NIF_Subcellular:sao965204139] +synonym: "dendrite spine" EXACT [] +synonym: "mushroom dendritic spine" NARROW [NIF_Subcellular:sao876577163] +synonym: "sessile dendritic spine" NARROW [NIF_Subcellular:sao1536532595] +synonym: "stubby dendritic spine" NARROW [NIF_Subcellular:sao317384566] +synonym: "thin dendritic spine" NARROW [NIF_Subcellular:sao1232858786] +xref: NIF_Subcellular:sao1799103720 +xref: Wikipedia:Dendritic_spine +is_a: GO:0044309 ! neuron spine +is_a: GO:0098794 ! postsynapse +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0043198 +name: dendritic shaft +namespace: cellular_component +def: "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln] +synonym: "trunk" RELATED [NIF_Subcellular:sao1078172392] +xref: NIF_Subcellular:sao2034472720 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0043199 +name: sulfate binding +namespace: molecular_function +def: "Binding to sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg] +is_a: GO:0043168 ! anion binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0043200 +name: response to amino acid +namespace: biological_process +alt_id: GO:0010237 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:ef, GOC:mlg] +synonym: "response to amino acid stimulus" EXACT [GOC:dos] +is_a: GO:0001101 ! response to acid chemical +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0043201 +name: response to leucine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:0043202 +name: lysosomal lumen +namespace: cellular_component +def: "The volume enclosed within the lysosomal membrane." [GOC:jl, PMID:15213228] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0043203 +name: axon hillock +namespace: cellular_component +def: "Portion of the neuronal cell soma from which the axon originates." [GOC:nln] +xref: NIF_Subcellular:sao627227260 +xref: Wikipedia:Axon_hillock +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon +relationship: part_of GO:0043025 ! neuronal cell body + +[Term] +id: GO:0043204 +name: perikaryon +namespace: cellular_component +def: "The portion of the cell soma (neuronal cell body) that excludes the nucleus." [GOC:jl] +synonym: "cell soma cytoplasm" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043025 ! neuronal cell body + +[Term] +id: GO:0043207 +name: response to external biotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:0043208 +name: glycosphingolipid binding +namespace: molecular_function +def: "Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl] +is_a: GO:0046625 ! sphingolipid binding +is_a: GO:0051861 ! glycolipid binding + +[Term] +id: GO:0043209 +name: myelin sheath +namespace: cellular_component +def: "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao593830697, Wikipedia:Myelin] +synonym: "astrocyte sheath" NARROW [NIF_Subcellular:nlx_subcell_20090204] +synonym: "oligodendrocyte myelin sheath" NARROW [NIF_Subcellular:sao1279474730] +synonym: "Schwann cell myelin sheath" NARROW [] +xref: FMA:62983 +xref: NIF_Subcellular:sao593830697 +xref: Wikipedia:Myelin +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0043210 +name: alkanesulfonate binding +namespace: molecular_function +def: "Binding to alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0043211 +name: ABC-type carbohydrate transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane." [GOC:mlg] +synonym: "ATP-dependent carbohydrate transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled carbohydrate transmembrane transporter activity" BROAD [] +synonym: "carbohydrate ABC transporter" NARROW [] +synonym: "carbohydrate-transporting ATPase activity" EXACT [] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0043212 +name: carbohydrate-exporting ABC transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)." [GOC:mlg] +synonym: "carbohydrate-exporting ATPase activity" BROAD [] +is_a: GO:0043211 ! ABC-type carbohydrate transporter activity + +[Term] +id: GO:0043213 +name: bacteriocin transport +namespace: biological_process +def: "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0043214 +name: ABC-type bacteriocin transporter activity +namespace: molecular_function +def: "Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate." [GOC:mlg, PMID:33040342] +synonym: "ABC-type bacteriocin transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled bacteriocin transmembrane transporter activity" RELATED [] +synonym: "bacteriocin ABC transporter" EXACT [] +is_a: GO:0008559 ! ABC-type xenobiotic transporter activity +is_a: GO:0015440 ! ABC-type peptide transporter activity +is_a: GO:0022885 ! bacteriocin transmembrane transporter activity + +[Term] +id: GO:0043215 +name: daunorubicin transport +namespace: biological_process +def: "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0043216 +name: obsolete ATPase-coupled daunorubicin transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg] +comment: This term was obsoleted because it represents a substrate-specific version of the general term GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activity. +synonym: "ATP-dependent daunorubicin transmembrane transporter activity" EXACT [] +synonym: "daunorubicin ABC transporter" NARROW [] +synonym: "daunorubicin-transporting ATPase activity" EXACT [] +xref: RHEA:33147 +is_obsolete: true +consider: GO:0008559 + +[Term] +id: GO:0043217 +name: myelin maintenance +namespace: biological_process +def: "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0042552 ! myelination + +[Term] +id: GO:0043218 +name: compact myelin +namespace: cellular_component +def: "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao1123256993] +synonym: "oligodendrocyte compact myelin" NARROW [NIF_Subcellular:sao1186642361] +synonym: "Schwann cell compact myelin" NARROW [] +xref: NIF_Subcellular:sao1123256993 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0043219 +name: lateral loop +namespace: cellular_component +def: "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh] +synonym: "oligodendrocyte paranodal termination" RELATED [NIF_Subcellular:sao1354781919] +synonym: "paranodal loop" RELATED [NIF_Subcellular:sao1354781919] +synonym: "Schwann cell paranodal termination" RELATED [NIF_Subcellular:sao1067215520] +xref: NIF_Subcellular:sao1067215520 +xref: NIF_Subcellular:sao1354781919 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043209 ! myelin sheath + +[Term] +id: GO:0043220 +name: Schmidt-Lanterman incisure +namespace: cellular_component +alt_id: GO:0044287 +def: "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh] +synonym: "Schmidt-Lanterman cleft" EXACT [] +xref: NIF_Subcellular:sao254777664 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043218 ! compact myelin + +[Term] +id: GO:0043221 +name: SMC family protein binding +namespace: molecular_function +def: "Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531] +synonym: "structural maintenance of chromosomes family protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043223 +name: cytoplasmic SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "cytoplasmic cullin complex" EXACT [] +synonym: "cytoplasmic SCF complex" EXACT [] +synonym: "cytoplasmic Skp1/Cul1/F-box protein complex" EXACT [] +is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0043224 +name: nuclear SCF ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] +synonym: "nuclear cullin complex" EXACT [] +synonym: "nuclear SCF complex" EXACT [] +synonym: "nuclear Skp1/Cul1/F-box protein complex" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0043225 +name: ATPase-coupled inorganic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in)." [GOC:mlg] +synonym: "anion ABC transporter" NARROW [] +synonym: "anion transmembrane-transporting ATPase activity" RELATED [] +synonym: "anion-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent anion transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled anion transmembrane transporter activity" EXACT [] +xref: Reactome:R-HSA-1454916 "The ABCC family mediates organic anion transport" +xref: Reactome:R-HSA-5690340 "Defective ABCC6 does not transport organic anion from cytosol to extracellular region" +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0043226 +name: organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_pir +xref: NIF_Subcellular:sao1539965131 +xref: Wikipedia:Organelle +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0043227 +name: membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] +synonym: "membrane-enclosed organelle" EXACT [] +xref: NIF_Subcellular:sao414196390 +is_a: GO:0043226 ! organelle + +[Term] +id: GO:0043228 +name: non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +synonym: "biological condensate" NARROW [] +synonym: "non-membrane-enclosed organelle" EXACT [] +xref: NIF_Subcellular:sao1456184038 +is_a: GO:0043226 ! organelle + +[Term] +id: GO:0043229 +name: intracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_pir +is_a: GO:0043226 ! organelle +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0043230 +name: extracellular organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479] +subset: goslim_pir +is_a: GO:0043226 ! organelle +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0043231 +name: intracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] +subset: goslim_pir +synonym: "intracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0043227 ! membrane-bounded organelle +is_a: GO:0043229 ! intracellular organelle + +[Term] +id: GO:0043232 +name: intracellular non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] +subset: goslim_mouse +subset: goslim_pir +synonym: "intracellular non-membrane-enclosed organelle" EXACT [] +is_a: GO:0043228 ! non-membrane-bounded organelle +is_a: GO:0043229 ! intracellular organelle + +[Term] +id: GO:0043233 +name: organelle lumen +namespace: cellular_component +def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] +is_a: GO:0031974 ! membrane-enclosed lumen +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0043235 +name: receptor complex +namespace: cellular_component +def: "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0043236 +name: laminin binding +namespace: molecular_function +alt_id: GO:0043238 +alt_id: GO:0043239 +def: "Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells." [GOC:ecd] +synonym: "laminin-2 binding" NARROW [] +synonym: "laminin-4 binding" NARROW [] +is_a: GO:0005515 ! protein binding +is_a: GO:0050840 ! extracellular matrix binding + +[Term] +id: GO:0043237 +name: laminin-1 binding +namespace: molecular_function +def: "Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators] +synonym: "laminin-111 binding" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043236 ! laminin binding + +[Term] +id: GO:0043240 +name: Fanconi anaemia nuclear complex +namespace: cellular_component +def: "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742] +synonym: "FA complex" EXACT [] +synonym: "FA core complex" EXACT [] +synonym: "FA nuclear complex" EXACT [] +synonym: "Fanconi anaemia complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0043242 +name: negative regulation of protein-containing complex disassembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +synonym: "down regulation of protein complex disassembly" EXACT [] +synonym: "down-regulation of protein complex disassembly" EXACT [] +synonym: "downregulation of protein complex disassembly" EXACT [] +synonym: "inhibition of protein complex disassembly" NARROW [] +synonym: "negative regulation of protein complex disassembly" RELATED [] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0043243 +name: positive regulation of protein-containing complex disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +synonym: "activation of protein complex disassembly" NARROW [] +synonym: "positive regulation of protein complex disassembly" RELATED [] +synonym: "stimulation of protein complex disassembly" NARROW [] +synonym: "up regulation of protein complex disassembly" EXACT [] +synonym: "up-regulation of protein complex disassembly" EXACT [] +synonym: "upregulation of protein complex disassembly" EXACT [] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0043244 +name: regulation of protein-containing complex disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl] +synonym: "regulation of protein complex disassembly" RELATED [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0043245 +name: extraorganismal space +namespace: cellular_component +def: "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0043246 +name: megasome +namespace: cellular_component +def: "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0043247 +name: telomere maintenance in response to DNA damage +namespace: biological_process +def: "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784] +synonym: "DNA damage response, telomere maintenance" EXACT [] +is_a: GO:0000723 ! telomere maintenance +is_a: GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0043248 +name: proteasome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471] +synonym: "26S proteasome assembly" NARROW [] +synonym: "proteasome complex assembly" EXACT [] +synonym: "proteasome maturation" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0043249 +name: erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl] +synonym: "RBC maturation" EXACT [CL:0000232] +synonym: "red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048821 ! erythrocyte development + +[Term] +id: GO:0043250 +name: sodium-dependent organic anion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators] +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0043251 +name: sodium-dependent organic anion transport +namespace: biological_process +def: "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0043252 +name: sodium-independent organic anion transport +namespace: biological_process +def: "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0043253 +name: chloroplast ribosome +namespace: cellular_component +def: "A ribosome contained within a chloroplast." [GOC:ecd] +is_a: GO:0009547 ! plastid ribosome +relationship: part_of GO:0009570 ! chloroplast stroma + +[Term] +id: GO:0043254 +name: regulation of protein-containing complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein complex assembly." [GOC:jl] +synonym: "regulation of protein complex assembly" RELATED [] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0043255 +name: regulation of carbohydrate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl] +synonym: "regulation of carbohydrate anabolism" EXACT [] +synonym: "regulation of carbohydrate biosynthesis" EXACT [] +synonym: "regulation of carbohydrate formation" EXACT [] +synonym: "regulation of carbohydrate synthesis" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009889 ! regulation of biosynthetic process +relationship: regulates GO:0016051 ! carbohydrate biosynthetic process + +[Term] +id: GO:0043256 +name: laminin complex +namespace: cellular_component +def: "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354] +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005604 ! basement membrane + +[Term] +id: GO:0043257 +name: laminin-8 complex +namespace: cellular_component +def: "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-411 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043258 +name: laminin-9 complex +namespace: cellular_component +def: "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-421 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043259 +name: laminin-10 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-511 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043260 +name: laminin-11 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-521 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043261 +name: laminin-12 complex +namespace: cellular_component +def: "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354] +synonym: "laminin-213 complex" EXACT [GOC:dph, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0043262 +name: adenosine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + H2O = AMP + phosphate." [EC:3.6.1.5, PMID:1470606] +synonym: "adenosine diphosphatase activity" EXACT [] +synonym: "ADPase" BROAD [EC:3.6.1.5] +synonym: "ADPase activity" RELATED [EC:3.6.1.5] +synonym: "ATP diphosphohydrolase activity" RELATED [EC:3.6.1.5] +synonym: "ATP-diphosphatase activity" RELATED [EC:3.6.1.5] +xref: MetaCyc:APYRASE-RXN +xref: RHEA:61436 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0043263 +name: cellulosome +namespace: cellular_component +alt_id: GO:1990296 +def: "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609, PMID:15197390, PMID:20373916] +synonym: "scaffoldin complex" NARROW [] +xref: Wikipedia:Cellulosome +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0043264 +name: extracellular non-membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl] +synonym: "extracellular non-membrane-enclosed organelle" EXACT [] +is_a: GO:0043228 ! non-membrane-bounded organelle +is_a: GO:0043230 ! extracellular organelle + +[Term] +id: GO:0043265 +name: ectoplasm +namespace: cellular_component +def: "Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0043266 +name: regulation of potassium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "regulation of K+ conductance" NARROW [] +synonym: "regulation of K+ transport" EXACT [] +synonym: "regulation of potassium conductance" NARROW [] +synonym: "regulation of potassium ion conductance" NARROW [] +synonym: "regulation of potassium transport" EXACT [] +is_a: GO:0010959 ! regulation of metal ion transport +relationship: regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043267 +name: negative regulation of potassium ion transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "down regulation of potassium ion transport" EXACT [] +synonym: "down-regulation of potassium ion transport" EXACT [] +synonym: "downregulation of potassium ion transport" EXACT [] +synonym: "inhibition of potassium ion transport" NARROW [] +synonym: "negative regulation of K+ transport" EXACT [] +synonym: "negative regulation of potassium ion conductance" NARROW [] +synonym: "negative regulation of potassium transport" EXACT [] +synonym: "regulation of K+ conductance" NARROW [] +synonym: "regulation of potassium conductance" NARROW [] +synonym: "transmembrane conductance regulator activity" RELATED [] +is_a: GO:0043266 ! regulation of potassium ion transport +is_a: GO:0043271 ! negative regulation of ion transport +relationship: negatively_regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043268 +name: positive regulation of potassium ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "activation of potassium ion transport" NARROW [] +synonym: "positive regulation of K+ conductance" NARROW [] +synonym: "positive regulation of K+ transport" EXACT [] +synonym: "positive regulation of potassium conductance" NARROW [] +synonym: "positive regulation of potassium ion conductance" NARROW [] +synonym: "positive regulation of potassium transport" EXACT [] +synonym: "stimulation of potassium ion transport" NARROW [] +synonym: "up regulation of potassium ion transport" EXACT [] +synonym: "up-regulation of potassium ion transport" EXACT [] +synonym: "upregulation of potassium ion transport" EXACT [] +is_a: GO:0043266 ! regulation of potassium ion transport +is_a: GO:0043270 ! positive regulation of ion transport +relationship: positively_regulates GO:0006813 ! potassium ion transport + +[Term] +id: GO:0043269 +name: regulation of ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043270 +name: positive regulation of ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "activation of ion transport" NARROW [] +synonym: "stimulation of ion transport" NARROW [] +synonym: "up regulation of ion transport" EXACT [] +synonym: "up-regulation of ion transport" EXACT [] +synonym: "upregulation of ion transport" EXACT [] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043271 +name: negative regulation of ion transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +synonym: "down regulation of ion transport" EXACT [] +synonym: "down-regulation of ion transport" EXACT [] +synonym: "downregulation of ion transport" EXACT [] +synonym: "inhibition of ion transport" NARROW [] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006811 ! ion transport + +[Term] +id: GO:0043272 +name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl] +synonym: "ethylene anabolism during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] +synonym: "ethylene biosynthetic process during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] +synonym: "ethylene formation during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] +synonym: "ethylene synthesis during jasmonic acid and ethylene-dependent systemic resistance" RELATED [] +is_a: GO:0009693 ! ethylene biosynthetic process +relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance + +[Term] +id: GO:0043273 +name: CTPase activity +namespace: molecular_function +alt_id: GO:0061747 +alt_id: GO:0061748 +def: "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators] +synonym: "CTPase activity, coupled" RELATED [] +synonym: "cytidine triphosphatase activity" EXACT [] +synonym: "single-stranded DNA-dependent CTPase activity" NARROW [] +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0043274 +name: phospholipase binding +namespace: molecular_function +def: "Binding to a phospholipase." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0043275 +name: obsolete glutamate carboxypeptidase II activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl] +comment: This term was made obsolete because it represents a gene product. +synonym: "acetylaspartylglutamate dipeptidase activity" EXACT [] +synonym: "folate hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "folylpolyglutamate hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "glutamate carboxypeptidase II activity" EXACT [] +synonym: "membrane glutamate carboxypeptidase" NARROW [EC:3.4.17.21] +synonym: "mGCP" RELATED [EC:3.4.17.21] +synonym: "microsomal gamma-glutamyl carboxypeptidase" NARROW [EC:3.4.17.21] +synonym: "N-acetylated alpha-linked acidic dipeptidase activity" RELATED [EC:3.4.17.21] +synonym: "N-acetylated-alpha-linked-amino dipeptidase activity" RELATED [EC:3.4.17.21] +synonym: "N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)" RELATED [EC:3.4.17.21] +synonym: "N-acetylated-gamma-linked-acidic dipeptidase activity" RELATED [EC:3.4.17.21] +synonym: "NAALA dipeptidase activity" RELATED [EC:3.4.17.21] +synonym: "NAALADase activity" RELATED [EC:3.4.17.21] +synonym: "prostate-specific membrane antigen" RELATED [EC:3.4.17.21] +synonym: "prostrate-specific membrane antigen" RELATED [EC:3.4.17.21] +synonym: "PSM antigen" RELATED [EC:3.4.17.21] +synonym: "PSMA" RELATED [EC:3.4.17.21] +synonym: "pteroylpoly-gamma-glutamate carboxypeptidase activity" RELATED [EC:3.4.17.21] +synonym: "pteroylpoly-gamma-glutamate hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "pteroylpolygammaglutamyl hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "pteroylpolyglutamate hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "pteroylpolyglutamic acid hydrolase activity" RELATED [EC:3.4.17.21] +synonym: "rat NAAG peptidase" NARROW [EC:3.4.17.21] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0043276 +name: anoikis +namespace: biological_process +def: "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/] +synonym: "detachment induced cell death" EXACT [] +synonym: "suspension induced apoptosis" EXACT [] +xref: Wikipedia:Anoikis +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0043277 +name: apoptotic cell clearance +namespace: biological_process +def: "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684] +comment: Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. +synonym: "apoptotic cell removal" EXACT [] +synonym: "efferocytosis" EXACT [PMID:17548650] +synonym: "programmed cell clearance" EXACT [] +is_a: GO:0006909 ! phagocytosis + +[Term] +id: GO:0043278 +name: response to morphine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:ef, GOC:jl] +is_a: GO:0014072 ! response to isoquinoline alkaloid + +[Term] +id: GO:0043279 +name: response to alkaloid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:jl] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0043280 +name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +def: "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis] +synonym: "activation of caspase activity" NARROW [] +synonym: "positive regulation of caspase activity" BROAD [] +synonym: "stimulation of caspase activity" NARROW [] +synonym: "up regulation of caspase activity" EXACT [] +synonym: "up-regulation of caspase activity" EXACT [] +synonym: "upregulation of caspase activity" EXACT [] +is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:0043281 +name: regulation of cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +alt_id: GO:0043026 +def: "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis] +synonym: "regulation of caspase activation" NARROW [] +synonym: "regulation of caspase activity" BROAD [] +is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:0043282 +name: pharyngeal muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators] +is_a: GO:0007517 ! muscle organ development +relationship: part_of GO:0060465 ! pharynx development + +[Term] +id: GO:0043286 +name: regulation of poly(3-hydroxyalkanoate) biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] +synonym: "regulation of PHA" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) anabolism" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) biosynthesis" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) formation" EXACT [] +synonym: "regulation of poly(3-hydroxyalkanoate) synthesis" EXACT [] +is_a: GO:0009889 ! regulation of biosynthetic process +relationship: regulates GO:0042621 ! poly(3-hydroxyalkanoate) biosynthetic process + +[Term] +id: GO:0043287 +name: poly(3-hydroxyalkanoate) binding +namespace: molecular_function +def: "Binding to a poly(3-hydroxyalkanoate), a polyester of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl] +synonym: "PHA binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043288 +name: apocarotenoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl] +synonym: "apo carotenoid metabolic process" EXACT [] +synonym: "apocarotenoid metabolism" EXACT [] +is_a: GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0043289 +name: apocarotenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, PMID:27485225] +synonym: "apo carotenoid biosynthetic process" EXACT [] +synonym: "apocarotenoid anabolism" EXACT [] +synonym: "apocarotenoid biosynthesis" EXACT [] +synonym: "apocarotenoid formation" EXACT [] +synonym: "apocarotenoid synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0043290 +name: apocarotenoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm] +synonym: "apo carotenoid catabolic process" EXACT [] +synonym: "apocarotenoid breakdown" EXACT [] +synonym: "apocarotenoid catabolism" EXACT [] +synonym: "apocarotenoid degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0043288 ! apocarotenoid metabolic process + +[Term] +id: GO:0043291 +name: RAVE complex +namespace: cellular_component +def: "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802] +synonym: "regulator of the (H+)-ATPase of the vacuolar and endosomal membranes" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0043292 +name: contractile fiber +namespace: cellular_component +def: "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194] +synonym: "contractile fibre" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +is_a: GO:0099512 ! supramolecular fiber +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0043293 +name: apoptosome +namespace: cellular_component +def: "A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137] +xref: Wikipedia:Apoptosome +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0043294 +name: mitochondrial glutamate synthase complex (NADH) +namespace: cellular_component +def: "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] +is_a: GO:0031027 ! glutamate synthase complex (NADH) +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0043295 +name: glutathione binding +namespace: molecular_function +def: "Binding to glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732] +is_a: GO:0043168 ! anion binding +is_a: GO:0072341 ! modified amino acid binding +is_a: GO:1900750 ! oligopeptide binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0043296 +name: apical junction complex +namespace: cellular_component +def: "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556] +synonym: "apical cell junction complex" EXACT [GOC:mah] +synonym: "apical junction" EXACT [] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0043297 +name: apical junction assembly +namespace: biological_process +def: "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556] +synonym: "apical junction complex assembly" EXACT [GOC:mah] +is_a: GO:0007043 ! cell-cell junction assembly + +[Term] +id: GO:0043299 +name: leukocyte degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, ISBN:0781735149] +synonym: "immune cell degranulation" EXACT [] +synonym: "immune cell granule exocytosis" EXACT [] +synonym: "leucocyte degranulation" EXACT [] +synonym: "leukocyte granule exocytosis" EXACT [] +is_a: GO:0002252 ! immune effector process +is_a: GO:0045055 ! regulated exocytosis +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0043300 +name: regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] +synonym: "regulation of immune cell degranulation" EXACT [] +synonym: "regulation of immune cell granule exocytosis" EXACT [] +synonym: "regulation of leucocyte degranulation" EXACT [] +synonym: "regulation of leukocyte granule exocytosis" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:1903305 ! regulation of regulated secretory pathway +relationship: regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043301 +name: negative regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149] +synonym: "down regulation of leukocyte degranulation" EXACT [] +synonym: "down-regulation of leukocyte degranulation" EXACT [] +synonym: "downregulation of leukocyte degranulation" EXACT [] +synonym: "inhibition of leukocyte degranulation" NARROW [] +synonym: "negative regulation of immune cell degranulation" EXACT [] +synonym: "negative regulation of leucocyte degranulation" EXACT [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:1903306 ! negative regulation of regulated secretory pathway +relationship: negatively_regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043302 +name: positive regulation of leukocyte degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149] +synonym: "activation of leukocyte degranulation" NARROW [] +synonym: "positive regulation of immune cell degranulation" EXACT [] +synonym: "positive regulation of leucocyte degranulation" EXACT [] +synonym: "stimulation of leukocyte degranulation" NARROW [] +synonym: "up regulation of leukocyte degranulation" EXACT [] +synonym: "up-regulation of leukocyte degranulation" EXACT [] +synonym: "upregulation of leukocyte degranulation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:1903307 ! positive regulation of regulated secretory pathway +relationship: positively_regulates GO:0043299 ! leukocyte degranulation + +[Term] +id: GO:0043303 +name: mast cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149] +synonym: "mast cell granule exocytosis" EXACT [] +is_a: GO:0002279 ! mast cell activation involved in immune response +is_a: GO:0032418 ! lysosome localization +is_a: GO:0043299 ! leukocyte degranulation +is_a: GO:0051656 ! establishment of organelle localization +relationship: part_of GO:0002448 ! mast cell mediated immunity + +[Term] +id: GO:0043304 +name: regulation of mast cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149] +synonym: "regulation of mast cell granule exocytosis" EXACT [] +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0033006 ! regulation of mast cell activation involved in immune response +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043305 +name: negative regulation of mast cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149] +synonym: "down regulation of mast cell degranulation" EXACT [] +synonym: "down-regulation of mast cell degranulation" EXACT [] +synonym: "downregulation of mast cell degranulation" EXACT [] +synonym: "inhibition of mast cell degranulation" NARROW [] +synonym: "negative regulation of mast cell granule exocytosis" EXACT [] +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0033007 ! negative regulation of mast cell activation involved in immune response +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043304 ! regulation of mast cell degranulation +relationship: negatively_regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043306 +name: positive regulation of mast cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149] +synonym: "activation of mast cell degranulation" NARROW [] +synonym: "positive regulation of mast cell granule exocytosis" EXACT [] +synonym: "stimulation of mast cell degranulation" NARROW [] +synonym: "up regulation of mast cell degranulation" EXACT [] +synonym: "up-regulation of mast cell degranulation" EXACT [] +synonym: "upregulation of mast cell degranulation" EXACT [] +is_a: GO:0033008 ! positive regulation of mast cell activation involved in immune response +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043304 ! regulation of mast cell degranulation +relationship: positively_regulates GO:0043303 ! mast cell degranulation + +[Term] +id: GO:0043307 +name: eosinophil activation +namespace: biological_process +def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149] +is_a: GO:0036230 ! granulocyte activation + +[Term] +id: GO:0043308 +name: eosinophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149] +synonym: "eosinophil granule exocytosis" EXACT [] +is_a: GO:0002278 ! eosinophil activation involved in immune response +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0002447 ! eosinophil mediated immunity + +[Term] +id: GO:0043309 +name: regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149] +synonym: "regulation of eosinophil granule exocytosis" EXACT [] +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0050776 ! regulation of immune response +is_a: GO:1902566 ! regulation of eosinophil activation +relationship: regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043310 +name: negative regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149] +synonym: "down regulation of eosinophil degranulation" EXACT [] +synonym: "down-regulation of eosinophil degranulation" EXACT [] +synonym: "downregulation of eosinophil degranulation" EXACT [] +synonym: "inhibition of eosinophil degranulation" NARROW [] +synonym: "negative regulation of eosinophil granule exocytosis" EXACT [] +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043309 ! regulation of eosinophil degranulation +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:1902567 ! negative regulation of eosinophil activation +relationship: negatively_regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043311 +name: positive regulation of eosinophil degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149] +synonym: "activation of eosinophil degranulation" NARROW [] +synonym: "positive regulation of eosinophil granule exocytosis" EXACT [] +synonym: "stimulation of eosinophil degranulation" NARROW [] +synonym: "up regulation of eosinophil degranulation" EXACT [] +synonym: "up-regulation of eosinophil degranulation" EXACT [] +synonym: "upregulation of eosinophil degranulation" EXACT [] +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043309 ! regulation of eosinophil degranulation +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:1902568 ! positive regulation of eosinophil activation +relationship: positively_regulates GO:0043308 ! eosinophil degranulation + +[Term] +id: GO:0043312 +name: neutrophil degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149] +synonym: "heterophil degranulation" RELATED [] +synonym: "neutrophil granule exocytosis" EXACT [] +is_a: GO:0002283 ! neutrophil activation involved in immune response +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0002446 ! neutrophil mediated immunity + +[Term] +id: GO:0043313 +name: regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149] +synonym: "regulation of neutrophil granule exocytosis" EXACT [] +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0050776 ! regulation of immune response +is_a: GO:1902563 ! regulation of neutrophil activation +relationship: regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043314 +name: negative regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149] +synonym: "down regulation of neutrophil degranulation" EXACT [] +synonym: "down-regulation of neutrophil degranulation" EXACT [] +synonym: "downregulation of neutrophil degranulation" EXACT [] +synonym: "inhibition of neutrophil degranulation" NARROW [] +synonym: "negative regulation of neutrophil granule exocytosis" EXACT [] +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043313 ! regulation of neutrophil degranulation +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:1902564 ! negative regulation of neutrophil activation +relationship: negatively_regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043315 +name: positive regulation of neutrophil degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149] +synonym: "activation of neutrophil degranulation" NARROW [] +synonym: "positive regulation of neutrophil granule exocytosis" EXACT [] +synonym: "stimulation of neutrophil degranulation" NARROW [] +synonym: "up regulation of neutrophil degranulation" EXACT [] +synonym: "up-regulation of neutrophil degranulation" EXACT [] +synonym: "upregulation of neutrophil degranulation" EXACT [] +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043313 ! regulation of neutrophil degranulation +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:1902565 ! positive regulation of neutrophil activation +relationship: positively_regulates GO:0043312 ! neutrophil degranulation + +[Term] +id: GO:0043316 +name: cytotoxic T cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149] +synonym: "cytotoxic T cell granule exocytosis" EXACT [] +synonym: "cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "cytotoxic T-cell degranulation" EXACT [] +synonym: "cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0002286 ! T cell activation involved in immune response +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0001913 ! T cell mediated cytotoxicity + +[Term] +id: GO:0043317 +name: regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149] +synonym: "regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043318 +name: negative regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149] +synonym: "down regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "down-regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "downregulation of cytotoxic T cell degranulation" EXACT [] +synonym: "inhibition of cytotoxic T cell degranulation" NARROW [] +synonym: "negative regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043319 +name: positive regulation of cytotoxic T cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149] +synonym: "activation of cytotoxic T cell degranulation" NARROW [] +synonym: "positive regulation of cytotoxic T cell granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T lymphocyte degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T lymphocyte granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T-cell degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T-cell granule exocytosis" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte degranulation" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte granule exocytosis" EXACT [] +synonym: "stimulation of cytotoxic T cell degranulation" NARROW [] +synonym: "up regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "up-regulation of cytotoxic T cell degranulation" EXACT [] +synonym: "upregulation of cytotoxic T cell degranulation" EXACT [] +is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043317 ! regulation of cytotoxic T cell degranulation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0043316 ! cytotoxic T cell degranulation + +[Term] +id: GO:0043320 +name: natural killer cell degranulation +namespace: biological_process +def: "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149] +synonym: "natural killer cell granule exocytosis" EXACT [] +synonym: "NK cell degranulation" EXACT [] +synonym: "NK cell granule exocytosis" EXACT [] +is_a: GO:0002323 ! natural killer cell activation involved in immune response +is_a: GO:0043299 ! leukocyte degranulation +relationship: part_of GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0043321 +name: regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149] +synonym: "regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "regulation of NK cell degranulation" EXACT [] +synonym: "regulation of NK cell granule exocytosis" EXACT [] +is_a: GO:0032814 ! regulation of natural killer cell activation +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +is_a: GO:0043300 ! regulation of leukocyte degranulation +relationship: regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043322 +name: negative regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149] +synonym: "down regulation of natural killer cell degranulation" EXACT [] +synonym: "down-regulation of natural killer cell degranulation" EXACT [] +synonym: "downregulation of natural killer cell degranulation" EXACT [] +synonym: "inhibition of natural killer cell degranulation" NARROW [] +synonym: "negative regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "negative regulation of NK cell degranulation" EXACT [] +synonym: "negative regulation of NK cell granule exocytosis" EXACT [] +is_a: GO:0032815 ! negative regulation of natural killer cell activation +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0043321 ! regulation of natural killer cell degranulation +is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity +relationship: negatively_regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043323 +name: positive regulation of natural killer cell degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149] +synonym: "activation of natural killer cell degranulation" NARROW [] +synonym: "positive regulation of natural killer cell granule exocytosis" EXACT [] +synonym: "positive regulation of NK cell degranulation" EXACT [] +synonym: "positive regulation of NK cell granule exocytosis" EXACT [] +synonym: "stimulation of natural killer cell degranulation" NARROW [] +synonym: "up regulation of natural killer cell degranulation" EXACT [] +synonym: "up-regulation of natural killer cell degranulation" EXACT [] +synonym: "upregulation of natural killer cell degranulation" EXACT [] +is_a: GO:0032816 ! positive regulation of natural killer cell activation +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0043321 ! regulation of natural killer cell degranulation +is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity +relationship: positively_regulates GO:0043320 ! natural killer cell degranulation + +[Term] +id: GO:0043324 +name: pigment metabolic process involved in developmental pigmentation +namespace: biological_process +def: "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732] +synonym: "pigment metabolic process during developmental pigmentation" RELATED [GOC:dph, GOC:tb] +synonym: "pigment metabolism during developmental pigmentation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043474 ! pigment metabolic process involved in pigmentation +relationship: part_of GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0043325 +name: phosphatidylinositol-3,4-bisphosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0043326 +name: chemotaxis to folate +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0051593 ! response to folic acid + +[Term] +id: GO:0043327 +name: chemotaxis to cAMP +namespace: biological_process +def: "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators] +synonym: "chemotaxis to 3',5' cAMP" EXACT [] +synonym: "chemotaxis to 3',5'-cAMP" EXACT [] +synonym: "chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "chemotaxis to cyclic AMP" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0043328 +name: protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway +namespace: biological_process +def: "The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343] +synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] +synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway +is_a: GO:0072666 ! establishment of protein localization to vacuole +relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway + +[Term] +id: GO:0043329 +name: obsolete protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway +namespace: biological_process +def: "OBSOLETE. The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl] +comment: The reason for obsoleting is that the term is not cleary defined, ie the membrane to which proteins are being targeted is not specified. +synonym: "protein membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein targeting to membrane during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein targeting to membrane during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] +synonym: "protein targeting to membrane during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] +synonym: "protein-membrane targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043330 +name: response to exogenous dsRNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators] +comment: Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. +synonym: "response to exogenous double-stranded RNA" EXACT [] +synonym: "response to viral dsRNA" NARROW [] +is_a: GO:0043331 ! response to dsRNA + +[Term] +id: GO:0043331 +name: response to dsRNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl] +synonym: "response to double-stranded RNA" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0043332 +name: mating projection tip +namespace: cellular_component +def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] +synonym: "conjugation tube tip" NARROW [] +synonym: "shmoo tip" NARROW [] +is_a: GO:0030427 ! site of polarized growth +is_a: GO:0051286 ! cell tip +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0043333 +name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity +namespace: molecular_function +alt_id: GO:0102005 +def: "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity" EXACT [] +xref: EC:2.1.1.201 +xref: MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043334 +name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043335 +name: protein unfolding +namespace: biological_process +def: "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0043336 +name: site-specific telomere resolvase activity +namespace: molecular_function +def: "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598] +comment: Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. +synonym: "ResT" NARROW [] +synonym: "TelN" NARROW [] +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0043337 +name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl] +synonym: "cardiolipin synthase" BROAD [] +synonym: "cardiolipin synthetase" BROAD [] +xref: MetaCyc:RXN-8141 +xref: Reactome:R-HSA-1483063 "PG and CDP-DAG are converted to CL by CRLS1" +xref: RHEA:32931 +is_a: GO:0030572 ! phosphatidyltransferase activity + +[Term] +id: GO:0043338 +name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477, RHEA:25690] +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase" BROAD [] +xref: EC:2.7.7.67 +xref: RHEA:25690 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0043353 +name: enucleate erythrocyte differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators] +synonym: "enucleate RBC differentiation" EXACT [CL:0000232] +synonym: "enucleate red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0043354 +name: enucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators] +synonym: "enucleate RBC maturation" EXACT [CL:0000232] +synonym: "enucleate red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0043249 ! erythrocyte maturation +relationship: part_of GO:0048822 ! enucleate erythrocyte development + +[Term] +id: GO:0043362 +name: nucleate erythrocyte maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl] +synonym: "nucleate RBC maturation" EXACT [CL:0000232] +synonym: "nucleate red blood cell maturation" EXACT [CL:0000232] +is_a: GO:0043249 ! erythrocyte maturation +relationship: part_of GO:0048823 ! nucleate erythrocyte development + +[Term] +id: GO:0043363 +name: nucleate erythrocyte differentiation +namespace: biological_process +def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl] +synonym: "nucleate RBC differentiation" EXACT [CL:0000232] +synonym: "nucleate red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0043364 +name: glycyl-radical enzyme activating activity +namespace: molecular_function +def: "Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [GOC:jl, PMID:24486374] +subset: goslim_pir +synonym: "catalysis of free radical formation" BROAD [] +xref: EC:1.97.1.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043365 +name: [formate-C-acetyltransferase]-activating enzyme activity +namespace: molecular_function +alt_id: GO:0008862 +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109] +synonym: "[pyruvate formate-lyase]-activating enzyme activity" RELATED [EC:1.97.1.4] +synonym: "formate acetyltransferase activating enzyme activity" RELATED [EC:1.97.1.4] +synonym: "formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity" RELATED [EC:1.97.1.4] +synonym: "formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)" RELATED [EC:1.97.1.4] +synonym: "formate-C-acetyltransferase-activating enzyme" RELATED [EC:1.97.1.4] +synonym: "PFL activase activity" RELATED [EC:1.97.1.4] +synonym: "PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity" RELATED [EC:1.97.1.4] +synonym: "pyruvate formate-lyase-activating enzyme" RELATED [EC:1.97.1.4] +xref: EC:1.97.1.4 +xref: MetaCyc:TDCEACT-RXN +xref: RHEA:19225 +is_a: GO:0043364 ! glycyl-radical enzyme activating activity + +[Term] +id: GO:0043366 +name: beta selection +namespace: biological_process +def: "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149, PMID:12220932] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043367 +name: CD4-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD4-positive, alpha beta T cell development" RELATED [GOC:add] +synonym: "CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] +synonym: "CD4-positive, alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta T-cell differentiation" EXACT [] +synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0035710 ! CD4-positive, alpha-beta T cell activation +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043368 +name: positive T cell selection +namespace: biological_process +def: "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722] +synonym: "positive T lymphocyte selection" EXACT [] +synonym: "positive T-cell selection" EXACT [] +synonym: "positive T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection + +[Term] +id: GO:0043369 +name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149] +synonym: "CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive/CD8-positive, alpha-beta T cell lineage commitment" EXACT [] +is_a: GO:0002360 ! T cell lineage commitment +relationship: part_of GO:0043368 ! positive T cell selection + +[Term] +id: GO:0043370 +name: regulation of CD4-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of CD4-positive T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] +synonym: "regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] +synonym: "regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043371 +name: negative regulation of CD4-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "down-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "downregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "inhibition of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "negative regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] +synonym: "negative regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "negative regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation +relationship: negatively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043372 +name: positive regulation of CD4-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "positive regulation of CD4-positive T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T cell development" RELATED [GOC:add] +synonym: "positive regulation of CD4-positive, alpha beta T cell differentiation" EXACT [GOC:bf] +synonym: "positive regulation of CD4-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "positive regulation of CD4-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of CD4-positive, alpha beta T cell differentiation" NARROW [] +synonym: "up regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "up-regulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +synonym: "upregulation of CD4-positive, alpha beta T cell differentiation" EXACT [] +is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation +relationship: positively_regulates GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043373 +name: CD4-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149] +synonym: "CD4-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD4-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD4-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002363 ! alpha-beta T cell lineage commitment +is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0043367 ! CD4-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043374 +name: CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "CD8-positive, alpha-beta T cell development" RELATED [GOC:add] +synonym: "CD8-positive, alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta T-cell differentiation" EXACT [] +synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0036037 ! CD8-positive, alpha-beta T cell activation +is_a: GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0043375 +name: CD8-positive, alpha-beta T cell lineage commitment +namespace: biological_process +def: "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149] +synonym: "CD8-positive, alpha-beta T cell fate commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T lymphocyte lineage commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T-cell lineage commitment" EXACT [] +synonym: "CD8-positive, alpha-beta T-lymphocyte lineage commitment" EXACT [] +is_a: GO:0002363 ! alpha-beta T cell lineage commitment +is_a: GO:0043369 ! CD4-positive or CD8-positive, alpha-beta T cell lineage commitment +relationship: part_of GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043376 +name: regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation +relationship: regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043377 +name: negative regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "down-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "downregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "inhibition of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "negative regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "negative regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] +is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation +relationship: negatively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043378 +name: positive regulation of CD8-positive, alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "positive regulation of CD8-positive T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive T-cell differentiation" EXACT [] +synonym: "positive regulation of CD8-positive T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T-cell differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha beta T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of CD8-positive, alpha-beta T cell development" RELATED [GOC:add] +synonym: "stimulation of CD8-positive, alpha-beta T cell differentiation" NARROW [] +synonym: "up regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "up-regulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +synonym: "upregulation of CD8-positive, alpha-beta T cell differentiation" EXACT [] +is_a: GO:0043376 ! regulation of CD8-positive, alpha-beta T cell differentiation +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation +relationship: positively_regulates GO:0043374 ! CD8-positive, alpha-beta T cell differentiation + +[Term] +id: GO:0043379 +name: memory T cell differentiation +namespace: biological_process +def: "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "memory T cell development" RELATED [GOC:add] +synonym: "memory T lymphocyte differentiation" EXACT [] +synonym: "memory T-cell differentiation" EXACT [] +synonym: "memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0002292 ! T cell differentiation involved in immune response +is_a: GO:0090715 ! immunological memory formation process + +[Term] +id: GO:0043380 +name: regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of memory T cell development" RELATED [GOC:add] +synonym: "regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "regulation of memory T-cell differentiation" EXACT [] +synonym: "regulation of memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043381 +name: negative regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of memory T cell differentiation" EXACT [] +synonym: "down-regulation of memory T cell differentiation" EXACT [] +synonym: "downregulation of memory T cell differentiation" EXACT [] +synonym: "inhibition of memory T cell differentiation" NARROW [] +synonym: "negative regulation of memory T cell development" RELATED [GOC:add] +synonym: "negative regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of memory T-cell differentiation" EXACT [] +synonym: "negative regulation of memory T-lymphocyte differentiation" EXACT [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0043380 ! regulation of memory T cell differentiation +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043382 +name: positive regulation of memory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of memory T cell differentiation" NARROW [] +synonym: "positive regulation of memory T cell development" RELATED [GOC:add] +synonym: "positive regulation of memory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of memory T-cell differentiation" EXACT [] +synonym: "positive regulation of memory T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of memory T cell differentiation" NARROW [] +synonym: "up regulation of memory T cell differentiation" EXACT [] +synonym: "up-regulation of memory T cell differentiation" EXACT [] +synonym: "upregulation of memory T cell differentiation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0043380 ! regulation of memory T cell differentiation +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0043379 ! memory T cell differentiation + +[Term] +id: GO:0043383 +name: negative T cell selection +namespace: biological_process +def: "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722] +synonym: "negative T lymphocyte selection" EXACT [] +synonym: "negative T-cell selection" EXACT [] +synonym: "negative T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection + +[Term] +id: GO:0043384 +name: pre-T cell receptor complex +namespace: cellular_component +def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932] +synonym: "pre-T lymphocyte receptor complex" EXACT [] +synonym: "pre-T-cell receptor complex" EXACT [] +synonym: "pre-T-lymphocyte receptor complex" EXACT [] +synonym: "pre-TCR complex" EXACT [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0043385 +name: mycotoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] +synonym: "mycotoxin metabolism" EXACT [] +is_a: GO:0009404 ! toxin metabolic process + +[Term] +id: GO:0043386 +name: mycotoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] +synonym: "mycotoxin anabolism" EXACT [] +synonym: "mycotoxin biosynthesis" EXACT [] +synonym: "mycotoxin formation" EXACT [] +synonym: "mycotoxin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0043385 ! mycotoxin metabolic process + +[Term] +id: GO:0043387 +name: mycotoxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [GOC:jl] +synonym: "mycotoxin breakdown" EXACT [] +synonym: "mycotoxin catabolism" EXACT [] +synonym: "mycotoxin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0043385 ! mycotoxin metabolic process + +[Term] +id: GO:0043388 +name: positive regulation of DNA binding +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] +synonym: "activation of DNA binding" NARROW [] +synonym: "stimulation of DNA binding" NARROW [] +synonym: "up regulation of DNA binding" EXACT [] +synonym: "up-regulation of DNA binding" EXACT [] +synonym: "upregulation of DNA binding" EXACT [] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:0043392 +name: negative regulation of DNA binding +namespace: biological_process +def: "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] +synonym: "down regulation of DNA binding" EXACT [] +synonym: "down-regulation of DNA binding" EXACT [] +synonym: "downregulation of DNA binding" EXACT [] +synonym: "inhibition of DNA binding" NARROW [] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:0043393 +name: regulation of protein binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein binding." [GOC:go_curators] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0043394 +name: proteoglycan binding +namespace: molecular_function +def: "Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732] +is_a: GO:0005515 ! protein binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0043395 +name: heparan sulfate proteoglycan binding +namespace: molecular_function +def: "Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732] +synonym: "heparin proteoglycan binding" RELATED [] +is_a: GO:0043394 ! proteoglycan binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0043396 +name: corticotropin-releasing hormone secretion +namespace: biological_process +def: "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914] +synonym: "corticotropin-releasing factor secretion" EXACT [] +synonym: "CRF secretion" EXACT [] +synonym: "CRH secretion" EXACT [] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0043397 +name: regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914] +synonym: "regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "regulation of CRF secretion" EXACT [] +synonym: "regulation of CRH secretion" EXACT [] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0043398 +name: HLH domain binding +namespace: molecular_function +def: "Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0043399 +name: tRNA A64-2'-O-ribosylphosphate transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819] +synonym: "initiator tRNA phosphoribosyl-transferase activity" EXACT [] +is_a: GO:0016763 ! pentosyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043400 +name: cortisol secretion +namespace: biological_process +def: "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [PMID:11027914] +synonym: "hydrocortisone secretion" EXACT [CHEBI:17650] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0035933 ! glucocorticoid secretion + +[Term] +id: GO:0043401 +name: steroid hormone mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724] +synonym: "steroid hormone mediated signalling" EXACT [] +is_a: GO:0009755 ! hormone-mediated signaling pathway +relationship: part_of GO:0071383 ! cellular response to steroid hormone stimulus + +[Term] +id: GO:0043402 +name: glucocorticoid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347] +synonym: "glucocorticoid mediated signalling" EXACT [] +is_a: GO:0043401 ! steroid hormone mediated signaling pathway +relationship: part_of GO:0071385 ! cellular response to glucocorticoid stimulus + +[Term] +id: GO:0043403 +name: skeletal muscle tissue regeneration +namespace: biological_process +def: "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119] +synonym: "myofiber turnover" RELATED [] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0043404 +name: corticotropin-releasing hormone receptor activity +namespace: molecular_function +alt_id: GO:0031636 +def: "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity." [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857] +synonym: "adrenocorticotropin-releasing hormone receptor activity" EXACT [] +synonym: "corticotropin-releasing factor receptor activity" EXACT [GOC:bf] +synonym: "CRF receptor activity" EXACT [GOC:bf] +synonym: "CRH receptor activity" EXACT [GOC:bf] +is_a: GO:0001653 ! peptide receptor activity + +[Term] +id: GO:0043405 +name: regulation of MAP kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "Regulation of MAPK activity" EXACT [GOC:dph] +synonym: "regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "regulation of mitogen-activated protein kinase activity" EXACT [] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0043406 +name: positive regulation of MAP kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "positive regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "positive regulation of mitogen-activated protein kinase activity" EXACT [] +synonym: "stimulation of MAPK activity" NARROW [] +synonym: "up regulation of MAPK activity" EXACT [] +synonym: "up-regulation of MAPK activity" EXACT [] +synonym: "upregulation of MAPK activity" EXACT [] +is_a: GO:0043405 ! regulation of MAP kinase activity +is_a: GO:0043410 ! positive regulation of MAPK cascade +is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0043407 +name: negative regulation of MAP kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators] +synonym: "down regulation of MAPK activity" EXACT [] +synonym: "down-regulation of MAPK activity" EXACT [] +synonym: "downregulation of MAPK activity" EXACT [] +synonym: "inhibition of MAPK activity" NARROW [] +synonym: "negative regulation of mitogen activated protein kinase activity" EXACT [] +synonym: "negative regulation of mitogen-activated protein kinase activity" EXACT [] +is_a: GO:0043405 ! regulation of MAP kinase activity +is_a: GO:0043409 ! negative regulation of MAPK cascade +is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0043408 +name: regulation of MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators] +synonym: "regulation of MAP kinase cascade" EXACT [GOC:signaling] +synonym: "regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "regulation of MAPKKK cascade" EXACT [GOC:signaling] +synonym: "regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] +synonym: "regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] +synonym: "regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0000165 ! MAPK cascade + +[Term] +id: GO:0043409 +name: negative regulation of MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators] +synonym: "down regulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "down regulation of MAPKKK cascade" EXACT [] +synonym: "down-regulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "down-regulation of MAPKKK cascade" EXACT [] +synonym: "downregulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "downregulation of MAPKKK cascade" EXACT [] +synonym: "inhibition of MAPK cascade" NARROW [GOC:signaling] +synonym: "inhibition of MAPKKK cascade" NARROW [] +synonym: "negative regulation of MAP kinase cascade" EXACT [GOC:signaling] +synonym: "negative regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "negative regulation of MAPKKK cascade" EXACT [GOC:signaling] +synonym: "negative regulation of mitogen activated protein kinase cascade" EXACT [GOC:signaling] +synonym: "negative regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "negative regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] +synonym: "negative regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +is_a: GO:0043408 ! regulation of MAPK cascade +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0000165 ! MAPK cascade + +[Term] +id: GO:0043410 +name: positive regulation of MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators] +synonym: "activation of MAPK cascade" NARROW [GOC:signaling] +synonym: "activation of MAPKKK cascade" NARROW [] +synonym: "positive regulation of MAP kinase cascade" EXACT [GOC:signaling] +synonym: "positive regulation of MAP kinase kinase kinase cascade" EXACT [] +synonym: "positive regulation of MAPKKK cascade" EXACT [GOC:signaling] +synonym: "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT [] +synonym: "positive regulation of mitogen-activated protein kinase cascade" EXACT [GOC:signaling] +synonym: "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT [] +synonym: "stimulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "stimulation of MAPKKK cascade" NARROW [] +synonym: "up regulation of MAPKKK cascade" EXACT [] +synonym: "up-regulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "up-regulation of MAPKKK cascade" EXACT [] +synonym: "upregulation of MAPK cascade" EXACT [GOC:signaling] +synonym: "upregulation of MAPKKK cascade" EXACT [] +is_a: GO:0043408 ! regulation of MAPK cascade +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0000165 ! MAPK cascade + +[Term] +id: GO:0043411 +name: obsolete myopalladin binding +namespace: molecular_function +def: "OBSOLETE. Binding to myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "myopalladin binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0043412 +name: macromolecule modification +namespace: biological_process +def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] +subset: goslim_pir +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0043413 +name: macromolecule glycosylation +namespace: biological_process +def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl] +is_a: GO:0043412 ! macromolecule modification +is_a: GO:0070085 ! glycosylation + +[Term] +id: GO:0043414 +name: macromolecule methylation +namespace: biological_process +def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] +is_a: GO:0032259 ! methylation +is_a: GO:0043412 ! macromolecule modification +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0043415 +name: positive regulation of skeletal muscle tissue regeneration +namespace: biological_process +def: "Any process that activates or increase the rate of skeletal muscle regeneration." [GOC:jl] +synonym: "activation of skeletal muscle regeneration" NARROW [] +synonym: "stimulation of skeletal muscle regeneration" NARROW [] +synonym: "up regulation of skeletal muscle regeneration" EXACT [] +synonym: "up-regulation of skeletal muscle regeneration" EXACT [] +synonym: "upregulation of skeletal muscle regeneration" EXACT [] +is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration +is_a: GO:0048639 ! positive regulation of developmental growth +relationship: positively_regulates GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0043416 +name: regulation of skeletal muscle tissue regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle." [GOC:jl] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0043417 +name: negative regulation of skeletal muscle tissue regeneration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl] +synonym: "down regulation of skeletal muscle regeneration" EXACT [] +synonym: "down-regulation of skeletal muscle regeneration" EXACT [] +synonym: "downregulation of skeletal muscle regeneration" EXACT [] +synonym: "inhibition of skeletal muscle regeneration" NARROW [] +is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0061045 ! negative regulation of wound healing +relationship: negatively_regulates GO:0043403 ! skeletal muscle tissue regeneration + +[Term] +id: GO:0043418 +name: homocysteine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl] +synonym: "homocysteine breakdown" EXACT [] +synonym: "homocysteine catabolism" EXACT [] +synonym: "homocysteine degradation" EXACT [] +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0050667 ! homocysteine metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0043419 +name: urea catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl] +synonym: "urea breakdown" EXACT [] +synonym: "urea catabolism" EXACT [] +synonym: "urea decomposition" EXACT [] +synonym: "urea degradation" EXACT [] +is_a: GO:0019627 ! urea metabolic process +is_a: GO:0043605 ! cellular amide catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0043420 +name: anthranilate metabolic process +namespace: biological_process +alt_id: GO:0018869 +def: "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [GOC:jl] +synonym: "2-aminobenzoate metabolic process" EXACT [] +synonym: "2-aminobenzoate metabolism" EXACT [] +synonym: "anthranilate metabolism" EXACT [] +synonym: "anthranilic acid metabolic process" NARROW [] +synonym: "anthranilic acid metabolism" NARROW [] +synonym: "ortho-aminobenzoic acid metabolic process" NARROW [] +synonym: "ortho-aminobenzoic acid metabolism" NARROW [] +xref: UM-BBD_pathwayID:abz2 +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0043421 +name: anthranilate catabolic process +namespace: biological_process +alt_id: GO:0019259 +def: "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [GOC:jl] +synonym: "2-aminobenzoate breakdown" EXACT [] +synonym: "2-aminobenzoate catabolic process" EXACT [] +synonym: "2-aminobenzoate catabolism" NARROW [] +synonym: "2-aminobenzoate degradation" EXACT [] +synonym: "anthranilate breakdown" EXACT [] +synonym: "anthranilate catabolism" EXACT [] +synonym: "anthranilate degradation" EXACT [] +synonym: "anthranilic acid catabolic process" NARROW [] +synonym: "anthranilic acid catabolism" NARROW [] +synonym: "ortho-aminobenzoic acid catabolic process" NARROW [] +synonym: "ortho-aminobenzoic acid catabolism" NARROW [] +xref: MetaCyc:2AMINOBENZDEG-PWY +is_a: GO:0009074 ! aromatic amino acid family catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0043420 ! anthranilate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0043422 +name: protein kinase B binding +namespace: molecular_function +def: "Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/] +synonym: "Akt binding" EXACT [] +synonym: "PKB binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043423 +name: 3-phosphoinositide-dependent protein kinase binding +namespace: molecular_function +def: "Binding to a 3-phosphoinositide-dependent protein kinase." [GOC:jl] +synonym: "phosphatidylinositol-3-phosphate-dependent protein kinase binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043424 +name: protein histidine kinase binding +namespace: molecular_function +def: "Binding to a protein histidine kinase." [GOC:jl] +synonym: "histidine kinase binding" EXACT [] +synonym: "histidine-protein kinase binding" EXACT [] +synonym: "protein-histidine kinase binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0043425 +name: bHLH transcription factor binding +namespace: molecular_function +def: "Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210] +is_a: GO:0140297 ! DNA-binding transcription factor binding + +[Term] +id: GO:0043426 +name: MRF binding +namespace: molecular_function +alt_id: GO:0051576 +alt_id: GO:0051577 +alt_id: GO:0051578 +alt_id: GO:0051579 +def: "Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875] +synonym: "Mrf4 binding" NARROW [] +synonym: "Myf5 binding" NARROW [] +synonym: "MyoD binding" NARROW [] +synonym: "myogenin binding" NARROW [] +is_a: GO:0043425 ! bHLH transcription factor binding + +[Term] +id: GO:0043427 +name: carbon fixation by 3-hydroxypropionate cycle +namespace: biological_process +def: "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028] +synonym: "3-hydroxypropionate cycle" EXACT [] +synonym: "3-hydroxypropionate pathway" EXACT [] +synonym: "hydroxypropionate cycle" EXACT [] +synonym: "hydroxypropionate pathway" EXACT [] +is_a: GO:0015977 ! carbon fixation + +[Term] +id: GO:0043428 +name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +xref: MetaCyc:RXN-9227 +xref: RHEA:44756 +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043429 +name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043430 +name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838] +comment: Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. +synonym: "2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] +xref: Reactome:R-HSA-2162188 "MDMQ10H2 is methylated to DMQ10H2 by COQ5" +xref: RHEA:44764 +is_a: GO:0008425 ! 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity + +[Term] +id: GO:0043431 +name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344] +synonym: "2-octaprenyl-6-hydroxy phenol methylase activity" EXACT [] +synonym: "3-demethylubiquinone-9 3-methyltransferase activity" EXACT [] +xref: MetaCyc:2.1.1.64-RXN +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0043433 +name: negative regulation of DNA-binding transcription factor activity +namespace: biological_process +alt_id: GO:1904168 +alt_id: GO:2000824 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl] +synonym: "down regulation of transcription factor activity" EXACT [] +synonym: "down-regulation of transcription factor activity" EXACT [] +synonym: "downregulation of transcription factor activity" EXACT [] +synonym: "inhibition of transcription factor activity" NARROW [] +synonym: "negative regulation of androgen receptor activity" NARROW [] +synonym: "negative regulation of DNA binding transcription factor activity" EXACT [] +synonym: "negative regulation of sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "negative regulation of thyroid hormone receptor activity" NARROW [] +synonym: "negative regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0043434 +name: response to peptide hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone] +synonym: "response to peptide hormone stimulus" EXACT [GOC:dos] +synonym: "response to polypeptide hormone stimulus" EXACT [] +is_a: GO:0009725 ! response to hormone +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:0043435 +name: response to corticotropin-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone] +synonym: "response to corticoliberin stimulus" EXACT [] +synonym: "response to corticotropin-releasing factor stimulus" EXACT [] +synonym: "response to corticotropin-releasing hormone stimulus" EXACT [GOC:dos] +synonym: "response to CRF stimulus" EXACT [] +synonym: "response to CRH stimulus" EXACT [] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0043436 +name: oxoacid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [Wikipedia:Oxyacid] +synonym: "keto acid metabolic process" EXACT [] +synonym: "keto acid metabolism" EXACT [] +synonym: "ketoacid metabolic process" EXACT [] +synonym: "ketoacid metabolism" EXACT [] +synonym: "oxo acid metabolic process" EXACT [] +synonym: "oxo acid metabolism" EXACT [] +synonym: "oxoacid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0043438 +name: acetoacetic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [Wikipedia:Acetoacetic_acid] +synonym: "3-oxobutanoate metabolic process" EXACT [] +synonym: "3-oxobutanoate metabolism" EXACT [] +synonym: "3-oxobutanoic acid metabolic process" EXACT [] +synonym: "3-oxobutanoic acid metabolism" EXACT [] +synonym: "acetoacetate metabolic process" EXACT [] +synonym: "acetoacetate metabolism" EXACT [] +synonym: "acetoacetic acid metabolism" EXACT [] +synonym: "beta ketobutyric acid metabolic process" EXACT [] +synonym: "beta ketobutyric acid metabolism" EXACT [] +synonym: "beta-ketobutyric acid metabolic process" EXACT [] +synonym: "beta-ketobutyric acid metabolism" EXACT [] +synonym: "diacetic acid metabolic process" EXACT [] +synonym: "diacetic acid metabolism" EXACT [] +is_a: GO:0046459 ! short-chain fatty acid metabolic process +is_a: GO:1902224 ! ketone body metabolic process + +[Term] +id: GO:0043441 +name: acetoacetic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] +synonym: "acetoacetic acid anabolism" EXACT [] +synonym: "acetoacetic acid biosynthesis" EXACT [] +synonym: "acetoacetic acid formation" EXACT [] +synonym: "acetoacetic acid synthesis" EXACT [] +is_a: GO:0043438 ! acetoacetic acid metabolic process +is_a: GO:0046951 ! ketone body biosynthetic process +is_a: GO:0051790 ! short-chain fatty acid biosynthetic process + +[Term] +id: GO:0043442 +name: acetoacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl] +synonym: "acetoacetic acid breakdown" EXACT [] +synonym: "acetoacetic acid catabolism" EXACT [] +synonym: "acetoacetic acid degradation" EXACT [] +is_a: GO:0019626 ! short-chain fatty acid catabolic process +is_a: GO:0043438 ! acetoacetic acid metabolic process +is_a: GO:0046952 ! ketone body catabolic process + +[Term] +id: GO:0043443 +name: acetone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone metabolic process" EXACT [] +synonym: "2-propanone metabolism" EXACT [] +synonym: "acetone metabolism" EXACT [] +synonym: "dimethyl ketone metabolic process" EXACT [] +synonym: "dimethyl ketone metabolism" EXACT [] +synonym: "propan-2-one metabolic process" EXACT [] +synonym: "propan-2-one metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1902224 ! ketone body metabolic process + +[Term] +id: GO:0043444 +name: acetone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone catabolic process" EXACT [] +synonym: "2-propanone catabolism" EXACT [] +synonym: "acetone breakdown" EXACT [] +synonym: "acetone catabolism" EXACT [] +synonym: "acetone degradation" EXACT [] +synonym: "dimethyl ketone catabolic process" EXACT [] +synonym: "dimethyl ketone catabolism" EXACT [] +synonym: "propan-2-one catabolic process" EXACT [] +synonym: "propan-2-one catabolism" EXACT [] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0043443 ! acetone metabolic process +is_a: GO:0046952 ! ketone body catabolic process + +[Term] +id: GO:0043445 +name: acetone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetone, propan-2-one." [GOC:jl] +synonym: "2-propanone biosynthesis" EXACT [] +synonym: "2-propanone biosynthetic process" EXACT [] +synonym: "acetone anabolism" EXACT [] +synonym: "acetone biosynthesis" EXACT [] +synonym: "acetone formation" EXACT [] +synonym: "acetone synthesis" EXACT [] +synonym: "dimethyl ketone biosynthesis" EXACT [] +synonym: "dimethyl ketone biosynthetic process" EXACT [] +synonym: "propan-2-one biosynthesis" EXACT [] +synonym: "propan-2-one biosynthetic process" EXACT [] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043443 ! acetone metabolic process +is_a: GO:0046951 ! ketone body biosynthetic process + +[Term] +id: GO:0043446 +name: cellular alkane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [GOC:jl, Wikipedia:Alkane] +subset: goslim_pir +synonym: "alkane metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0043447 +name: alkane biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane] +synonym: "alkane anabolism" EXACT [] +synonym: "alkane biosynthesis" EXACT [] +synonym: "alkane formation" EXACT [] +synonym: "alkane synthesis" EXACT [] +is_a: GO:0043446 ! cellular alkane metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0120251 ! hydrocarbon biosynthetic process + +[Term] +id: GO:0043448 +name: alkane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [GOC:jl, Wikipedia:Alkane] +synonym: "alkane breakdown" EXACT [] +synonym: "alkane catabolism" EXACT [] +synonym: "alkane degradation" EXACT [] +is_a: GO:0043446 ! cellular alkane metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process + +[Term] +id: GO:0043449 +name: cellular alkene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [GOC:jl, Wikipedia:Alkene] +subset: goslim_pir +synonym: "alkene metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:1900673 ! olefin metabolic process + +[Term] +id: GO:0043450 +name: alkene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene] +synonym: "alkene anabolism" EXACT [] +synonym: "alkene biosynthesis" EXACT [] +synonym: "alkene formation" EXACT [] +synonym: "alkene synthesis" EXACT [] +is_a: GO:0043449 ! cellular alkene metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1900674 ! olefin biosynthetic process + +[Term] +id: GO:0043451 +name: alkene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:jl, Wikipedia:Alkene] +synonym: "alkene breakdown" EXACT [] +synonym: "alkene catabolism" EXACT [] +synonym: "alkene degradation" EXACT [] +is_a: GO:0043449 ! cellular alkene metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0043452 +name: cellular alkyne metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [GOC:jl, GOC:krc, Wikipedia:Alkyne] +subset: goslim_pir +synonym: "alkyne metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0120246 ! acetylenic compound metabolic process +is_a: GO:0120252 ! hydrocarbon metabolic process + +[Term] +id: GO:0043453 +name: alkyne biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, GOC:krc, Wikipedia:Alkyne] +synonym: "alkyne anabolism" EXACT [] +synonym: "alkyne biosynthesis" EXACT [] +synonym: "alkyne formation" EXACT [] +synonym: "alkyne synthesis" EXACT [] +is_a: GO:0043452 ! cellular alkyne metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0120247 ! acetylenic compound biosynthetic process +is_a: GO:0120251 ! hydrocarbon biosynthetic process + +[Term] +id: GO:0043454 +name: alkyne catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2." [GOC:jl, GOC:krc, Wikipedia:Alkyne] +synonym: "alkyne breakdown" EXACT [] +synonym: "alkyne catabolism" EXACT [] +synonym: "alkyne degradation" EXACT [] +is_a: GO:0043452 ! cellular alkyne metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0120248 ! acetylenic compound catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process + +[Term] +id: GO:0043455 +name: regulation of secondary metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] +synonym: "regulation of secondary metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0043456 +name: regulation of pentose-phosphate shunt +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl] +synonym: "regulation of pentose phosphate pathway" EXACT [] +synonym: "regulation of pentose phosphate shunt" EXACT [] +synonym: "regulation of pentose-phosphate pathway" EXACT [] +is_a: GO:0019220 ! regulation of phosphate metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:1902031 ! regulation of NADP metabolic process +relationship: regulates GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:0043457 +name: regulation of cellular respiration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0045333 ! cellular respiration + +[Term] +id: GO:0043458 +name: ethanol biosynthetic process involved in glucose fermentation to ethanol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP." [GOC:dph, GOC:jl, GOC:tb] +synonym: "ethanol anabolism during fermentation" RELATED [] +synonym: "ethanol formation during fermentation" RELATED [] +synonym: "ethanol synthesis during fermentation" RELATED [] +is_a: GO:0006115 ! ethanol biosynthetic process +relationship: part_of GO:0019655 ! glycolytic fermentation to ethanol + +[Term] +id: GO:0043459 +name: obsolete response to short exposure to lithium ion +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444] +comment: This term was made obsolete because 'short' is not a quantitative or meaningful measurement of time. +synonym: "response to short exposure to lithium ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043460 +name: obsolete response to long exposure to lithium ion +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444] +comment: This term was made obsolete because 'long' is not a quantitative or meaningful measurement of time. +synonym: "response to long exposure to lithium ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043461 +name: proton-transporting ATP synthase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/] +synonym: "F-type ATPase complex assembly" EXACT [] +is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly + +[Term] +id: GO:0043462 +name: regulation of ATP-dependent activity +namespace: biological_process +def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl] +synonym: "regulation of adenosinetriphosphatase activity" EXACT [] +synonym: "regulation of ATPase activity" EXACT [] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0043463 +name: regulation of rhamnose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl] +synonym: "regulation of rhamnose breakdown" EXACT [] +synonym: "regulation of rhamnose catabolism" EXACT [] +synonym: "regulation of rhamnose degradation" EXACT [] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0019301 ! rhamnose catabolic process + +[Term] +id: GO:0043464 +name: malolactic fermentation +namespace: biological_process +def: "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948] +synonym: "L-malate fermentation" BROAD [] +synonym: "malate fermentation" BROAD [] +synonym: "malo-lactate fermentation" EXACT [] +synonym: "malolactate fermentation" EXACT [] +xref: Wikipedia:Malolactic_fermentation +is_a: GO:0006113 ! fermentation + +[Term] +id: GO:0043465 +name: regulation of fermentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0006113 ! fermentation + +[Term] +id: GO:0043466 +name: pyrimidine nucleobase fermentation +namespace: biological_process +def: "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP." [GOC:jl] +synonym: "pyrimidine base fermentation" EXACT [GOC:go_curators] +synonym: "pyrimidine fermentation" RELATED [] +is_a: GO:0006208 ! pyrimidine nucleobase catabolic process +is_a: GO:0019666 ! nitrogenous compound fermentation + +[Term] +id: GO:0043467 +name: regulation of generation of precursor metabolites and energy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006091 ! generation of precursor metabolites and energy + +[Term] +id: GO:0043468 +name: regulation of fucose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0019317 ! fucose catabolic process + +[Term] +id: GO:0043469 +name: regulation of D-xylose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0042843 ! D-xylose catabolic process + +[Term] +id: GO:0043470 +name: regulation of carbohydrate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009894 ! regulation of catabolic process +relationship: regulates GO:0016052 ! carbohydrate catabolic process + +[Term] +id: GO:0043471 +name: regulation of cellular carbohydrate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0043472 +name: IgD binding +namespace: molecular_function +def: "Binding to an immunoglobulin of a D isotype." [PMID:12886015] +is_a: GO:0019865 ! immunoglobulin binding + +[Term] +id: GO:0043473 +name: pigmentation +namespace: biological_process +def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] +subset: goslim_chembl +subset: goslim_pir +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0043474 +name: pigment metabolic process involved in pigmentation +namespace: biological_process +def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb] +synonym: "pigment metabolic process during pigmentation" RELATED [GOC:dph, GOC:tb] +synonym: "pigment metabolism during pigmentation" RELATED [] +is_a: GO:0042440 ! pigment metabolic process +relationship: part_of GO:0043473 ! pigmentation + +[Term] +id: GO:0043475 +name: pigment metabolic process involved in pigment accumulation +namespace: biological_process +def: "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl] +synonym: "pigment metabolic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] +synonym: "pigment metabolism during pigment accumulation" RELATED [] +is_a: GO:0043474 ! pigment metabolic process involved in pigmentation +relationship: part_of GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043476 +name: pigment accumulation +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl] +synonym: "pigment accumulation in response to external stimulus" EXACT [] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0043477 +name: pigment biosynthetic process involved in pigment accumulation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb] +synonym: "pigment biosynthetic process during pigment accumulation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043475 ! pigment metabolic process involved in pigment accumulation +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0043478 +name: pigment accumulation in response to UV light +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0009411 ! response to UV +is_a: GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043479 +name: pigment accumulation in tissues in response to UV light +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0043478 ! pigment accumulation in response to UV light +is_a: GO:0043480 ! pigment accumulation in tissues + +[Term] +id: GO:0043480 +name: pigment accumulation in tissues +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl] +synonym: "organismal pigment accumulation" EXACT [] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0043476 ! pigment accumulation + +[Term] +id: GO:0043481 +name: anthocyanin accumulation in tissues in response to UV light +namespace: biological_process +def: "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl] +is_a: GO:0043479 ! pigment accumulation in tissues in response to UV light + +[Term] +id: GO:0043482 +name: cellular pigment accumulation +namespace: biological_process +def: "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl] +is_a: GO:0033059 ! cellular pigmentation +is_a: GO:0043476 ! pigment accumulation +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0043483 +name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb] +synonym: "anthocyanin biosynthesis during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] +synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in response to UV light" RELATED [GOC:dph, GOC:tb] +synonym: "anthocyanin biosynthetic process during anthocyanin accumulation in tissues in response to UV light stimulus" RELATED [] +is_a: GO:0009718 ! anthocyanin-containing compound biosynthetic process +is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation +relationship: part_of GO:0043481 ! anthocyanin accumulation in tissues in response to UV light + +[Term] +id: GO:0043484 +name: regulation of RNA splicing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0008380 ! RNA splicing + +[Term] +id: GO:0043485 +name: endosome to pigment granule transport +namespace: biological_process +def: "The directed movement of substances from endosomes to pigment granules." [GOC:jl] +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0048757 ! pigment granule maturation + +[Term] +id: GO:0043486 +name: histone exchange +namespace: biological_process +def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] +comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. +synonym: "histone chaperone" RELATED [GOC:vw] +synonym: "histone replacement" EXACT [] +is_a: GO:0034728 ! nucleosome organization + +[Term] +id: GO:0043487 +name: regulation of RNA stability +namespace: biological_process +def: "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl] +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0043488 +name: regulation of mRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl] +is_a: GO:0043487 ! regulation of RNA stability +is_a: GO:0061013 ! regulation of mRNA catabolic process + +[Term] +id: GO:0043489 +name: RNA stabilization +namespace: biological_process +def: "Prevention of degradation of RNA molecules." [GOC:go_curators] +is_a: GO:0043487 ! regulation of RNA stability +is_a: GO:1902369 ! negative regulation of RNA catabolic process + +[Term] +id: GO:0043490 +name: malate-aspartate shuttle +namespace: biological_process +def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663] +synonym: "malate aspartate shuttle" EXACT [] +synonym: "malate/aspartate shuttle" EXACT [] +synonym: "malate:aspartate shuttle" EXACT [] +xref: Wikipedia:Malate-aspartate_shuttle +is_a: GO:1990542 ! mitochondrial transmembrane transport +relationship: part_of GO:0022904 ! respiratory electron transport chain + +[Term] +id: GO:0043491 +name: protein kinase B signaling +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound." [GOC:bf, PMID:20517722] +synonym: "AKT signal transduction" EXACT [GOC:signaling] +synonym: "AKT signaling" EXACT [GOC:signaling] +synonym: "AKT signaling cascade" RELATED [] +synonym: "AKT signalling cascade" EXACT [] +synonym: "PKB signal transduction" EXACT [GOC:signaling] +synonym: "PKB signaling" EXACT [GOC:signaling] +synonym: "PKB signaling cascade" RELATED [] +synonym: "PKB signalling cascade" RELATED [] +synonym: "protein kinase B signal transduction" EXACT [GOC:signaling] +synonym: "protein kinase B signaling cascade" RELATED [GOC:signaling] +synonym: "protein kinase B signalling cascade" RELATED [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0043493 +name: viral terminase complex +namespace: cellular_component +def: "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides." [GOC:bf, GOC:bm, GOC:jl, GOC:mlg] +synonym: "phage terminase complex" NARROW [GOC:bm] +synonym: "virus terminase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0043494 +name: CLRC complex +namespace: cellular_component +def: "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi." [GOC:vw, PMID:16127433, PMID:20211136] +synonym: "Clr4-Rik1-Cul4 complex" EXACT [] +synonym: "CLRC ubiquitin ligase complex" EXACT [] +synonym: "Rik1 E3 ubiquitin ligase complex" EXACT [] +synonym: "Rik1-E3 ubiquitin ligase complex" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0031465 ! Cul4B-RING E3 ubiquitin ligase complex +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0043495 +name: protein-membrane adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle." [GOC:go_curators] +synonym: "anchoring" RELATED [] +synonym: "protein membrane adaptor" EXACT [] +synonym: "protein membrane adaptor activity" EXACT [] +synonym: "protein membrane anchor" RELATED [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0043496 +name: regulation of protein homodimerization activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb] +comment: Note that protein homodimerization is a molecular function: 'protein homodimerization activity ; GO:0042803'. +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0043497 +name: regulation of protein heterodimerization activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb] +comment: Note that protein heterodimerization is a molecular function: 'protein heterodimerization activity ; GO:0046982'. +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:0043498 +name: obsolete cell surface binding +namespace: molecular_function +def: "OBSOLETE. Binding to a component on the surface of a cell." [GOC:jl] +comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. +synonym: "cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0003823 +consider: GO:0005102 +consider: GO:0007155 +consider: GO:0009986 +consider: GO:0046812 + +[Term] +id: GO:0043499 +name: obsolete eukaryotic cell surface binding +namespace: molecular_function +def: "OBSOLETE. Binding to a component on the surface of a eukaryotic cell." [GOC:jl] +comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. +synonym: "eukaryotic cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0003823 +consider: GO:0005102 +consider: GO:0006952 +consider: GO:0009986 +consider: GO:0046812 + +[Term] +id: GO:0043500 +name: muscle adaptation +namespace: biological_process +def: "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +subset: goslim_pir +synonym: "muscle plasticity" RELATED [] +is_a: GO:0003012 ! muscle system process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0043501 +name: skeletal muscle adaptation +namespace: biological_process +def: "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +synonym: "skeletal muscle plasticity" RELATED [] +is_a: GO:0014888 ! striated muscle adaptation + +[Term] +id: GO:0043502 +name: regulation of muscle adaptation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle] +synonym: "regulation of muscle plasticity" RELATED [] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0090257 ! regulation of muscle system process +relationship: regulates GO:0043500 ! muscle adaptation + +[Term] +id: GO:0043503 +name: skeletal muscle fiber adaptation +namespace: biological_process +def: "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307] +synonym: "skeletal muscle fiber plasticity" RELATED [] +synonym: "skeletal muscle fibre plasticity" EXACT [] +synonym: "skeletal myofiber plasticity" EXACT [] +synonym: "skeletal myofibre plasticity" EXACT [] +is_a: GO:0051716 ! cellular response to stimulus +relationship: part_of GO:0043501 ! skeletal muscle adaptation + +[Term] +id: GO:0043504 +name: mitochondrial DNA repair +namespace: biological_process +def: "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976] +is_a: GO:0006281 ! DNA repair +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:0043505 +name: CENP-A containing nucleosome +namespace: cellular_component +def: "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641] +synonym: "CenH3 containing nucleosome" EXACT [] +synonym: "CENP-S-T-W-X" EXACT [GOC:vw, PMID:22304917] +synonym: "centromere specific nucleosome" RELATED [] +synonym: "centromere-specific nucleosome" RELATED [GOC:vw] +synonym: "centromeric nucleosome" RELATED [] +synonym: "CNP-T-W-S-X complex" EXACT [] +is_a: GO:0000786 ! nucleosome +relationship: part_of GO:0061638 ! CENP-A containing chromatin + +[Term] +id: GO:0043506 +name: regulation of JUN kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "regulation of JUNK activity" EXACT [] +is_a: GO:0043405 ! regulation of MAP kinase activity + +[Term] +id: GO:0043507 +name: positive regulation of JUN kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "positive regulation of JUNK activity" EXACT [] +synonym: "stimulation of JNK activity" NARROW [] +synonym: "up regulation of JNK activity" EXACT [] +synonym: "up-regulation of JNK activity" EXACT [] +synonym: "upregulation of JNK activity" EXACT [] +is_a: GO:0043406 ! positive regulation of MAP kinase activity +is_a: GO:0043506 ! regulation of JUN kinase activity + +[Term] +id: GO:0043508 +name: negative regulation of JUN kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl] +synonym: "down regulation of JNK activity" EXACT [] +synonym: "down-regulation of JNK activity" EXACT [] +synonym: "downregulation of JNK activity" EXACT [] +synonym: "inhibition of JNK activity" NARROW [] +synonym: "negative regulation of JUNK activity" EXACT [] +is_a: GO:0043407 ! negative regulation of MAP kinase activity +is_a: GO:0043506 ! regulation of JUN kinase activity +is_a: GO:0046329 ! negative regulation of JNK cascade + +[Term] +id: GO:0043509 +name: activin A complex +namespace: cellular_component +alt_id: GO:0048181 +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0043510 +name: activin B complex +namespace: cellular_component +alt_id: GO:0048182 +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0043511 +name: inhibin complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0043512 +name: inhibin A complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +is_a: GO:0043511 ! inhibin complex + +[Term] +id: GO:0043513 +name: inhibin B complex +namespace: cellular_component +def: "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl] +comment: Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. +is_a: GO:0043511 ! inhibin complex + +[Term] +id: GO:0043514 +name: interleukin-12 complex +namespace: cellular_component +def: "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512] +comment: Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. +synonym: "IL-12 complex" EXACT [GOC:mah] +synonym: "IL12A" NARROW [GOC:add] +synonym: "IL12B" NARROW [GOC:add] +synonym: "p35" NARROW [GOC:add] +synonym: "p40" NARROW [GOC:add] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0043515 +name: kinetochore binding +namespace: molecular_function +def: "Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0043516 +name: regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "regulation of p53 induced by DNA damage response" EXACT [] +is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043517 +name: positive regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "activation of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "positive regulation of p53 induced by DNA damage response" EXACT [] +synonym: "stimulation of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator +is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus +relationship: positively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043518 +name: negative regulation of DNA damage response, signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl] +synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator" EXACT [] +synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator" NARROW [] +synonym: "negative regulation of p53 induced by DNA damage response" EXACT [] +is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator +is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus +relationship: negatively_regulates GO:0030330 ! DNA damage response, signal transduction by p53 class mediator + +[Term] +id: GO:0043519 +name: regulation of myosin II filament organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] +synonym: "regulation of myosin II filament assembly or disassembly" RELATED [GOC:mah] +synonym: "regulation of myosin II filament organisation" EXACT [GOC:mah] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0031038 ! myosin II filament organization + +[Term] +id: GO:0043520 +name: regulation of myosin II filament assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0043519 ! regulation of myosin II filament organization +relationship: regulates GO:0031036 ! myosin II filament assembly + +[Term] +id: GO:0043521 +name: regulation of myosin II filament disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +is_a: GO:0043519 ! regulation of myosin II filament organization +relationship: regulates GO:0031037 ! myosin II filament disassembly + +[Term] +id: GO:0043522 +name: leucine zipper domain binding +namespace: molecular_function +def: "Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158] +synonym: "leucine zipper binding" EXACT [] +is_a: GO:0030275 ! LRR domain binding + +[Term] +id: GO:0043523 +name: regulation of neuron apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "regulation of apoptosis of neuronal cells" EXACT [] +synonym: "regulation of apoptosis of neurons" EXACT [] +synonym: "regulation of neuron apoptosis" NARROW [] +synonym: "regulation of neuron programmed cell death" EXACT [] +synonym: "regulation of neuronal cell programmed cell death" EXACT [] +synonym: "regulation of programmed cell death of neuronal cells" EXACT [] +synonym: "regulation of programmed cell death, neurons" EXACT [] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:1901214 ! regulation of neuron death +relationship: regulates GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0043524 +name: negative regulation of neuron apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "down regulation of neuron apoptosis" EXACT [] +synonym: "down-regulation of neuron apoptosis" EXACT [] +synonym: "downregulation of neuron apoptosis" EXACT [] +synonym: "inhibition of neuron apoptosis" NARROW [] +synonym: "negative regulation of neuron apoptosis" NARROW [] +synonym: "negative regulation of programmed cell death, neurons" EXACT [] +synonym: "neuron survival" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:0043523 ! regulation of neuron apoptotic process +is_a: GO:1901215 ! negative regulation of neuron death +relationship: negatively_regulates GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0043525 +name: positive regulation of neuron apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "activation of neuron apoptosis" NARROW [] +synonym: "positive regulation of neuron apoptosis" NARROW [] +synonym: "positive regulation of programmed cell death, neurons" EXACT [] +synonym: "stimulation of neuron apoptosis" NARROW [] +synonym: "up regulation of neuron apoptosis" EXACT [] +synonym: "up-regulation of neuron apoptosis" EXACT [] +synonym: "upregulation of neuron apoptosis" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0043523 ! regulation of neuron apoptotic process +is_a: GO:1901216 ! positive regulation of neuron death +relationship: positively_regulates GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0043526 +name: obsolete neuroprotection +namespace: biological_process +def: "OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [GOC:mtg_apoptosis, MSH:D017209, PMID:10208444, PMID:11909981, PMID:15905876] +comment: This term was made obsolete because it refers to assays rather than processes. If neuron death by apoptosis is assessed, consider using GO:0043523 regulation of neuron apoptotic process. If neuron death is assessed but the cell death modality isn't defined, refer to GO:0070997 neuron death. Where non-neuronal cells are involved, and/or processes other than cell death are described, please use other terms for annotation. +synonym: "neuroprotection" EXACT [] +xref: Wikipedia:Neuroprotection +is_obsolete: true + +[Term] +id: GO:0043527 +name: tRNA methyltransferase complex +namespace: cellular_component +def: "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl, PMID:24904644, PMID:9851972] +subset: goslim_pir +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0043528 +name: tRNA (m2G10) methyltransferase complex +namespace: cellular_component +def: "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842] +is_a: GO:0043527 ! tRNA methyltransferase complex + +[Term] +id: GO:0043529 +name: GET complex +namespace: cellular_component +def: "An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins." [GOC:krc, GOC:vw, PMID:16269340, PMID:18724936, PMID:32910895] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0043530 +name: adenosine 5'-monophosphoramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111, RHEA:67916] +synonym: "adenosine 5' monophosphoramidase activity" EXACT [] +synonym: "adenosine 5'-monophosphoramidate hydrolase activity" EXACT [] +xref: RHEA:67916 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043531 +name: ADP binding +namespace: molecular_function +def: "Binding to ADP, adenosine 5'-diphosphate." [GOC:jl] +synonym: "adenosine 5'-diphosphate binding" EXACT [] +synonym: "adenosine diphosphate binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0043532 +name: angiostatin binding +namespace: molecular_function +def: "Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043533 +name: inositol 1,3,4,5 tetrakisphosphate binding +namespace: molecular_function +def: "Binding to inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators] +synonym: "InsP4 binding" EXACT [] +synonym: "IP4 binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0043534 +name: blood vessel endothelial cell migration +namespace: biological_process +def: "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264] +is_a: GO:0043542 ! endothelial cell migration + +[Term] +id: GO:0043535 +name: regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +is_a: GO:0010594 ! regulation of endothelial cell migration +relationship: regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043536 +name: positive regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +synonym: "activation of blood vessel endothelial cell migration" NARROW [] +synonym: "stimulation of blood vessel endothelial cell migration" NARROW [] +synonym: "up regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "up-regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "upregulation of blood vessel endothelial cell migration" EXACT [] +is_a: GO:0010595 ! positive regulation of endothelial cell migration +is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration +relationship: positively_regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043537 +name: negative regulation of blood vessel endothelial cell migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators] +synonym: "down regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "down-regulation of blood vessel endothelial cell migration" EXACT [] +synonym: "downregulation of blood vessel endothelial cell migration" EXACT [] +synonym: "inhibition of blood vessel endothelial cell migration" NARROW [] +is_a: GO:0010596 ! negative regulation of endothelial cell migration +is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration +relationship: negatively_regulates GO:0043534 ! blood vessel endothelial cell migration + +[Term] +id: GO:0043538 +name: regulation of actin phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0031289 ! actin phosphorylation + +[Term] +id: GO:0043539 +name: protein serine/threonine kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a protein serine/threonine kinase." [GOC:go_curators] +synonym: "protein ser/thr kinase activator activity" EXACT [] +is_a: GO:0030295 ! protein kinase activator activity + +[Term] +id: GO:0043540 +name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex +namespace: cellular_component +def: "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so] +comment: Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future. +synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex" NARROW [] +synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex" NARROW [] +synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex" NARROW [] +synonym: "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex" NARROW [] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0043541 +name: UDP-N-acetylglucosamine transferase complex +namespace: cellular_component +def: "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246] +comment: See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0043542 +name: endothelial cell migration +namespace: biological_process +def: "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0043543 +name: protein acylation +namespace: biological_process +def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] +subset: goslim_yeast +synonym: "protein amino acid acylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0043544 +name: lipoamide binding +namespace: molecular_function +def: "Binding to lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators] +is_a: GO:0033218 ! amide binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0043545 +name: molybdopterin cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +synonym: "Moco metabolic process" EXACT [] +synonym: "Moco metabolism" EXACT [] +synonym: "molybdopterin cofactor metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0051189 ! prosthetic group metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0043546 +name: molybdopterin cofactor binding +namespace: molecular_function +def: "Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257] +synonym: "Moco binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0043547 +name: positive regulation of GTPase activity +namespace: biological_process +alt_id: GO:0032320 +alt_id: GO:0032321 +alt_id: GO:0032850 +alt_id: GO:0032851 +alt_id: GO:0032852 +alt_id: GO:0032853 +alt_id: GO:0032854 +alt_id: GO:0032855 +alt_id: GO:0043089 +def: "Any process that activates or increases the activity of a GTPase." [GOC:jl, GOC:mah] +synonym: "activation of GTPase activity" NARROW [] +synonym: "positive regulation of ARF GTPase activity" NARROW [] +synonym: "positive regulation of Cdc42 GTPase activity" NARROW [] +synonym: "positive regulation of Rab GTPase activity" NARROW [] +synonym: "positive regulation of Rac GTPase activity" NARROW [] +synonym: "positive regulation of Ral GTPase activity" NARROW [] +synonym: "positive regulation of Ran GTPase activity" NARROW [] +synonym: "positive regulation of Rap GTPase activity" NARROW [] +synonym: "positive regulation of Ras GTPase activity" NARROW [] +synonym: "positive regulation of Rho GTPase activity" NARROW [] +synonym: "stimulation of ARF GTPase activity" NARROW [] +synonym: "stimulation of Cdc42 GTPase activity" NARROW [] +synonym: "stimulation of GTPase activity" NARROW [] +synonym: "stimulation of Rab GTPase activity" NARROW [] +synonym: "stimulation of Rac GTPase activity" NARROW [] +synonym: "stimulation of Ral GTPase activity" NARROW [] +synonym: "stimulation of Ran GTPase activity" NARROW [] +synonym: "stimulation of Rap GTPase activity" NARROW [] +synonym: "stimulation of Ras GTPase activity" NARROW [] +synonym: "stimulation of Rho GTPase activity" NARROW [] +synonym: "up regulation of ARF GTPase activity" NARROW [] +synonym: "up regulation of Cdc42 GTPase activity" NARROW [] +synonym: "up regulation of GTPase activity" EXACT [] +synonym: "up regulation of Rab GTPase activity" NARROW [] +synonym: "up regulation of Rac GTPase activity" NARROW [] +synonym: "up regulation of Ral GTPase activity" NARROW [] +synonym: "up regulation of Ran GTPase activity" NARROW [] +synonym: "up regulation of Rap GTPase activity" NARROW [] +synonym: "up regulation of Ras GTPase activity" NARROW [] +synonym: "up regulation of Rho GTPase activity" NARROW [] +synonym: "up-regulation of ARF GTPase activity" NARROW [] +synonym: "up-regulation of Cdc42 GTPase activity" NARROW [] +synonym: "up-regulation of GTPase activity" EXACT [] +synonym: "up-regulation of Rab GTPase activity" NARROW [] +synonym: "up-regulation of Rac GTPase activity" NARROW [] +synonym: "up-regulation of Ral GTPase activity" NARROW [] +synonym: "up-regulation of Ran GTPase activity" NARROW [] +synonym: "up-regulation of Rap GTPase activity" NARROW [] +synonym: "up-regulation of Ras GTPase activity" NARROW [] +synonym: "up-regulation of Rho GTPase activity" NARROW [] +synonym: "upregulation of ARF GTPase activity" NARROW [] +synonym: "upregulation of Cdc42 GTPase activity" NARROW [] +synonym: "upregulation of GTPase activity" EXACT [] +synonym: "upregulation of Rab GTPase activity" NARROW [] +synonym: "upregulation of Rac GTPase activity" NARROW [] +synonym: "upregulation of Ral GTPase activity" NARROW [] +synonym: "upregulation of Ran GTPase activity" NARROW [] +synonym: "upregulation of Rap GTPase activity" NARROW [] +synonym: "upregulation of Ras GTPase activity" NARROW [] +synonym: "upregulation of Rho GTPase activity" NARROW [] +is_a: GO:0043087 ! regulation of GTPase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0043548 +name: phosphatidylinositol 3-kinase binding +namespace: molecular_function +def: "Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069] +synonym: "phosphoinositide 3-kinase binding" EXACT [] +synonym: "PI3K binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043549 +name: regulation of kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf] +is_a: GO:0042325 ! regulation of phosphorylation +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0043550 +name: regulation of lipid kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0043551 +name: regulation of phosphatidylinositol 3-kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf] +synonym: "regulation of phosphoinositide 3-kinase activity" EXACT [] +is_a: GO:0043550 ! regulation of lipid kinase activity + +[Term] +id: GO:0043552 +name: positive regulation of phosphatidylinositol 3-kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] +synonym: "activation of phosphatidylinositol 3-kinase activity" NARROW [] +synonym: "positive regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "stimulation of phosphatidylinositol 3-kinase activity" NARROW [] +synonym: "up regulation of phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "up-regulation of phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "upregulation of phosphatidylinositol 3-kinase activity" EXACT [] +is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity +is_a: GO:0090218 ! positive regulation of lipid kinase activity + +[Term] +id: GO:0043553 +name: negative regulation of phosphatidylinositol 3-kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf] +synonym: "down regulation of phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "down-regulation of phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "downregulation of phosphatidylinositol 3-kinase activity" EXACT [] +synonym: "inhibition of phosphatidylinositol 3-kinase activity" NARROW [] +synonym: "negative regulation of phosphoinositide 3-kinase activity" EXACT [] +synonym: "negative regulation of PI3K activity" EXACT [GOC:bf] +is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity +is_a: GO:0090219 ! negative regulation of lipid kinase activity + +[Term] +id: GO:0043554 +name: aerobic respiration, using arsenite as electron donor +namespace: biological_process +def: "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg] +is_a: GO:0009060 ! aerobic respiration +is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds + +[Term] +id: GO:0043555 +name: regulation of translation in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] +synonym: "translational stress response" EXACT [] +is_a: GO:0006417 ! regulation of translation +relationship: part_of GO:0033554 ! cellular response to stress + +[Term] +id: GO:0043556 +name: regulation of translation in response to oxidative stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] +is_a: GO:0032055 ! negative regulation of translation in response to stress +relationship: part_of GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0043557 +name: regulation of translation in response to osmotic stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] +is_a: GO:0043555 ! regulation of translation in response to stress +relationship: part_of GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0043558 +name: regulation of translational initiation in response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl] +synonym: "regulation of translation initiation in response to stress" EXACT [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0043555 ! regulation of translation in response to stress + +[Term] +id: GO:0043559 +name: insulin binding +namespace: molecular_function +def: "Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732] +is_a: GO:0005515 ! protein binding +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0043560 +name: insulin receptor substrate binding +namespace: molecular_function +def: "Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233] +synonym: "insulin receptor substrate [protein] binding" EXACT [] +synonym: "IRS [protein] binding" EXACT [] +synonym: "IRS binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043561 +name: regulation of translational initiation in response to osmotic stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb] +is_a: GO:0043557 ! regulation of translation in response to osmotic stress +is_a: GO:0043558 ! regulation of translational initiation in response to stress + +[Term] +id: GO:0043562 +name: cellular response to nitrogen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl] +is_a: GO:0031669 ! cellular response to nutrient levels + +[Term] +id: GO:0043563 +name: obsolete odorant transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl] +is_obsolete: true + +[Term] +id: GO:0043564 +name: Ku70:Ku80 complex +namespace: cellular_component +def: "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983] +synonym: "Ku70:Ku80 heterodimer" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0043565 +name: sequence-specific DNA binding +namespace: molecular_function +def: "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] +synonym: "sequence specific DNA binding" EXACT [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0043567 +name: regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "regulation of IGF receptor signaling pathway" EXACT [] +synonym: "regulation of IGF receptor signalling pathway" EXACT [] +synonym: "regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043568 +name: positive regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "activation of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of IGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of IGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +synonym: "stimulation of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of insulin-like growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway +relationship: positively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043569 +name: negative regulation of insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf] +synonym: "down regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of insulin-like growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of insulin-like growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of IGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of IGF receptor signalling pathway" EXACT [] +synonym: "negative regulation of insulin-like growth factor receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0043567 ! regulation of insulin-like growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048009 ! insulin-like growth factor receptor signaling pathway + +[Term] +id: GO:0043570 +name: maintenance of DNA repeat elements +namespace: biological_process +def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0043571 +name: maintenance of CRISPR repeat elements +namespace: biological_process +def: "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354] +synonym: "CRISPR element metabolic process" RELATED [] +synonym: "CRISPR element metabolism" RELATED [] +synonym: "maintenance of clustered regularly interspaced short palindromic repeat elements" EXACT [] +is_a: GO:0043570 ! maintenance of DNA repeat elements + +[Term] +id: GO:0043572 +name: plastid fission +namespace: biological_process +def: "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0043573 +name: leucoplast fission +namespace: biological_process +def: "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl] +is_a: GO:0043572 ! plastid fission + +[Term] +id: GO:0043574 +name: peroxisomal transport +namespace: biological_process +def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0043575 +name: detection of osmotic stimulus +namespace: biological_process +def: "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl] +is_a: GO:0006970 ! response to osmotic stress +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0043576 +name: regulation of respiratory gaseous exchange +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007585 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:0043577 +name: chemotropism +namespace: biological_process +def: "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613] +xref: Wikipedia:Chemotropism +is_a: GO:0009606 ! tropism +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0043578 +name: nuclear matrix organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah] +synonym: "nuclear matrix organisation" EXACT [] +synonym: "nuclear matrix organization and biogenesis" RELATED [GOC:mah] +synonym: "nucleoskeleton organization" EXACT [GOC:tb] +is_a: GO:0006997 ! nucleus organization + +[Term] +id: GO:0043579 +name: elaioplast organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl] +synonym: "elaioplast organisation" EXACT [] +synonym: "elaioplast organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0009659 ! leucoplast organization + +[Term] +id: GO:0043580 +name: periplasmic space organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah] +synonym: "periplasmic space organisation" EXACT [GOC:mah] +synonym: "periplasmic space organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043581 +name: obsolete mycelium development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae." [GOC:jl, ISBN:1580085792, PMID:12832397] +comment: The reason for obsoletion is that the term is ambiguous. Three more clearly defined terms have been created that should be considered in its place. +is_obsolete: true +consider: GO:0097736 +consider: GO:0097737 +consider: GO:0097738 + +[Term] +id: GO:0043582 +name: sporangium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium] +synonym: "sporangia development" EXACT [] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0043583 +name: ear development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023] +synonym: "hearing organ development" EXACT [] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0043584 +name: nose development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] +synonym: "nasus development" EXACT [] +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0043585 +name: nose morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl] +synonym: "nasus morphogenesis" EXACT [] +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0043584 ! nose development + +[Term] +id: GO:0043586 +name: tongue development +namespace: biological_process +def: "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] +synonym: "glossa development" NARROW [] +synonym: "lingua development" NARROW [] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0043587 +name: tongue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723] +synonym: "glossa morphogenesis" NARROW [] +synonym: "lingua morphogenesis" EXACT [] +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0043586 ! tongue development + +[Term] +id: GO:0043588 +name: skin development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] +synonym: "animal skin development" EXACT [] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0043589 +name: skin morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0043590 +name: bacterial nucleoid +namespace: cellular_component +def: "The region of a bacterial cell to which the DNA is confined." [GOC:jl] +is_a: GO:0009295 ! nucleoid +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0043591 +name: endospore external encapsulating structure +namespace: cellular_component +alt_id: GO:0055030 +def: "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041] +subset: goslim_pir +synonym: "endospore wall" EXACT [GOC:mah] +synonym: "peptidoglycan-based spore wall" EXACT [GOC:mtg_sensu] +synonym: "spore wall" BROAD [GOC:mtg_sensu] +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0043592 +name: exosporium +namespace: cellular_component +def: "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg] +synonym: "epispore" RELATED [] +synonym: "exospore" RELATED [] +synonym: "perispore" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043593 +name: endospore coat +namespace: cellular_component +def: "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043594 +name: outer endospore membrane +namespace: cellular_component +def: "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg] +is_a: GO:0019867 ! outer membrane +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043595 +name: endospore cortex +namespace: cellular_component +def: "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043591 ! endospore external encapsulating structure + +[Term] +id: GO:0043596 +name: nuclear replication fork +namespace: cellular_component +def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] +is_a: GO:0005657 ! replication fork +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0043597 +name: cytoplasmic replication fork +namespace: cellular_component +def: "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] +is_a: GO:0005657 ! replication fork +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0043598 +name: cytoplasmic DNA replication factor C complex +namespace: cellular_component +def: "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520] +synonym: "cytoplasmic clamp loader" EXACT [] +synonym: "cytoplasmic RFC" EXACT [] +is_a: GO:0005663 ! DNA replication factor C complex +relationship: part_of GO:0043600 ! cytoplasmic replisome + +[Term] +id: GO:0043599 +name: nuclear DNA replication factor C complex +namespace: cellular_component +def: "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842] +synonym: "nuclear RFC" EXACT [] +is_a: GO:0005663 ! DNA replication factor C complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0043600 +name: cytoplasmic replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu] +synonym: "prokaryotic replisome" EXACT [] +is_a: GO:0030894 ! replisome +relationship: part_of GO:0043597 ! cytoplasmic replication fork + +[Term] +id: GO:0043601 +name: nuclear replisome +namespace: cellular_component +def: "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu] +is_a: GO:0030894 ! replisome +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043596 ! nuclear replication fork + +[Term] +id: GO:0043602 +name: nitrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl] +synonym: "nitrate disassimilation" EXACT [] +synonym: "nitrate dissimilation" EXACT [] +is_a: GO:0042126 ! nitrate metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process + +[Term] +id: GO:0043603 +name: cellular amide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [GOC:curators] +subset: goslim_pir +synonym: "amide metabolism" EXACT [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0043604 +name: amide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process + +[Term] +id: GO:0043605 +name: cellular amide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [GOC:curators] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process + +[Term] +id: GO:0043606 +name: formamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] +synonym: "formamide metabolism" EXACT [] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0043607 +name: formamide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0043606 ! formamide metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0043608 +name: formamide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl] +is_a: GO:0043605 ! cellular amide catabolic process +is_a: GO:0043606 ! formamide metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0043609 +name: regulation of carbon utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of carbon utilization." [GOC:jl] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0015976 ! carbon utilization + +[Term] +id: GO:0043610 +name: regulation of carbohydrate utilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of carbohydrate utilization." [GOC:jl] +synonym: "regulation of sugar utilization" NARROW [GOC:mcc2] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0009758 ! carbohydrate utilization + +[Term] +id: GO:0043611 +name: isoprene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoprene, C5H8." [GOC:jl] +synonym: "2-methyl-1,3-butadiene metabolic process" EXACT [] +synonym: "2-methyl-1,3-butadiene metabolism" EXACT [] +synonym: "hemiterpene metabolic process" EXACT [] +synonym: "hemiterpene metabolism" EXACT [] +synonym: "isoprene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process +is_a: GO:1900673 ! olefin metabolic process + +[Term] +id: GO:0043612 +name: isoprene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoprene, C5H8." [GOC:jl] +synonym: "2-methyl-1,3-butadiene biosynthesis" EXACT [] +synonym: "2-methyl-1,3-butadiene biosynthetic process" EXACT [] +synonym: "hemiterpene biosynthesis" EXACT [] +synonym: "hemiterpene biosynthetic process" EXACT [] +is_a: GO:0043611 ! isoprene metabolic process +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:1900674 ! olefin biosynthetic process + +[Term] +id: GO:0043613 +name: isoprene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8." [GOC:jl] +synonym: "2-methyl-1,3-butadiene catabolic process" EXACT [] +synonym: "2-methyl-1,3-butadiene catabolism" EXACT [] +synonym: "hemiterpene catabolic process" EXACT [] +synonym: "hemiterpene catabolism" EXACT [] +is_a: GO:0043611 ! isoprene metabolic process +is_a: GO:0046247 ! terpene catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0043614 +name: multi-eIF complex +namespace: cellular_component +def: "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc] +synonym: "multifactor translation initiation factor (eIF) complex" EXACT [] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0043615 +name: astrocyte cell migration +namespace: biological_process +def: "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators] +synonym: "astrocyte migration" EXACT [] +synonym: "astrocytic glial cell migration" EXACT [] +is_a: GO:0008347 ! glial cell migration + +[Term] +id: GO:0043616 +name: keratinocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0043617 +name: cellular response to sucrose starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0043618 +name: regulation of transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0043620 ! regulation of DNA-templated transcription in response to stress + +[Term] +id: GO:0043619 +name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress +relationship: part_of GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0043620 +name: regulation of DNA-templated transcription in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH] +synonym: "regulation of DNA-dependent transcription in response to stress" EXACT [GOC:txnOH] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0043621 +name: protein self-association +namespace: molecular_function +def: "Binding to a domain within the same polypeptide." [GOC:jl] +subset: goslim_chembl +synonym: "intramolecular protein binding" EXACT [] +synonym: "protein self association" EXACT [] +synonym: "protein self binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0043622 +name: cortical microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] +synonym: "cortical microtubule cytoskeleton organization" EXACT [] +synonym: "cortical microtubule organisation" EXACT [] +synonym: "cortical microtubule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0030865 ! cortical cytoskeleton organization +is_a: GO:0031122 ! cytoplasmic microtubule organization + +[Term] +id: GO:0043625 +name: delta DNA polymerase complex +namespace: cellular_component +alt_id: GO:0005659 +def: "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614] +synonym: "delta-DNA polymerase complex" EXACT [] +is_a: GO:0042575 ! DNA polymerase complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043601 ! nuclear replisome + +[Term] +id: GO:0043626 +name: PCNA complex +namespace: cellular_component +def: "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735] +synonym: "PCNA homotrimer" EXACT [] +synonym: "proliferating cell nuclear antigen complex" EXACT [] +synonym: "sliding clamp" BROAD [] +is_a: GO:0044796 ! DNA polymerase processivity factor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0043627 +name: response to estrogen +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732] +synonym: "response to estrogen stimulus" EXACT [GOC:dos] +synonym: "response to oestrogen stimulus" EXACT [] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0043628 +name: ncRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl] +synonym: "ncRNA 3' end processing" EXACT [] +is_a: GO:0031123 ! RNA 3'-end processing +is_a: GO:0034470 ! ncRNA processing + +[Term] +id: GO:0043629 +name: ncRNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092] +synonym: "non-coding RNA polyadenylation" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0043630 +name: ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb] +synonym: "ncRNA polyadenylation during polyadenylation-dependent ncRNA catabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "ncRNA polyadenylation involved in poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0043629 ! ncRNA polyadenylation +relationship: part_of GO:0043634 ! polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0043631 +name: RNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0043632 +name: modification-dependent macromolecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] +is_a: GO:0044265 ! cellular macromolecule catabolic process + +[Term] +id: GO:0043633 +name: polyadenylation-dependent RNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc] +is_a: GO:0006401 ! RNA catabolic process +is_a: GO:0043632 ! modification-dependent macromolecule catabolic process + +[Term] +id: GO:0043634 +name: polyadenylation-dependent ncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc] +synonym: "poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0034661 ! ncRNA catabolic process +is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process + +[Term] +id: GO:0043635 +name: methylnaphthalene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687] +synonym: "1-methylnaphthalene catabolic process" NARROW [] +synonym: "1-methylnaphthalene catabolism" NARROW [] +synonym: "1-MN catabolic process" RELATED [] +synonym: "1-MN catabolism" RELATED [] +synonym: "2-methylnaphthalene catabolic process" NARROW [] +synonym: "2-methylnaphthalene catabolism" NARROW [] +synonym: "2-MN catabolic process" RELATED [] +synonym: "2-MN catabolism" RELATED [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0043636 +name: bisphenol A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [GOC:jl, Wikipedia:Bisphenol_A] +synonym: "bisphenol-A catabolic process" EXACT [] +synonym: "bisphenol-A catabolism" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0043637 +name: puromycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, PMID:8226694, Wikipedia:Puromycin] +synonym: "puromycin metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0043638 +name: puromycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [GOC:jl, Wikipedia:Puromycin] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0043637 ! puromycin metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0043639 +name: benzoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl] +synonym: "benzoate breakdown" EXACT [] +synonym: "benzoate catabolism" EXACT [] +synonym: "benzoate degradation" EXACT [] +is_a: GO:0018874 ! benzoate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0043640 +name: benzoate catabolic process via hydroxylation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503] +synonym: "benzoate breakdown via hydroxylation" EXACT [] +synonym: "benzoate degradation via hydroxylation" EXACT [] +xref: MetaCyc:PWY-2503 +is_a: GO:0043639 ! benzoate catabolic process + +[Term] +id: GO:0043641 +name: novobiocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl] +synonym: "novobiocin metabolism" EXACT [] +xref: Wikipedia:Novobiocin +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0043642 +name: novobiocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [GOC:jl] +xref: Wikipedia:Novobiocin +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0043641 ! novobiocin metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0043643 +name: tetracycline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline] +synonym: "tetracyclin metabolic process" EXACT [] +synonym: "tetracyclin metabolism" EXACT [] +synonym: "tetracycline metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:0043644 +name: tetracycline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [GOC:jl, Wikipedia:Tetracycline] +synonym: "tetracyclin biosynthesis" EXACT [] +synonym: "tetracyclin biosynthetic process" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043643 ! tetracycline metabolic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:0043645 +name: cephalosporin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin] +synonym: "cephalosporin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:0043646 +name: cephalosporin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [GOC:jl, Wikipedia:Cephalosporin] +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:0043645 ! cephalosporin metabolic process +is_a: GO:0044272 ! sulfur compound biosynthetic process + +[Term] +id: GO:0043647 +name: inositol phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:jl] +synonym: "inositol phosphate metabolism" EXACT [] +synonym: "myo-inositol phosphate metabolic process" NARROW [] +synonym: "myo-inositol phosphate metabolism" NARROW [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:0043648 +name: dicarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] +synonym: "dicarboxylate metabolic process" EXACT [] +synonym: "dicarboxylate metabolism" EXACT [] +synonym: "dicarboxylic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0043649 +name: dicarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "dicarboxylate catabolic process" EXACT [] +synonym: "dicarboxylate catabolism" EXACT [] +synonym: "dicarboxylic acid breakdown" EXACT [] +synonym: "dicarboxylic acid catabolism" EXACT [] +synonym: "dicarboxylic acid degradation" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0043650 +name: dicarboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "dicarboxylate biosynthesis" EXACT [] +synonym: "dicarboxylate biosynthetic process" EXACT [] +synonym: "dicarboxylic acid anabolism" EXACT [] +synonym: "dicarboxylic acid biosynthesis" EXACT [] +synonym: "dicarboxylic acid formation" EXACT [] +synonym: "dicarboxylic acid synthesis" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0043651 +name: linoleic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid] +synonym: "linoleic acid metabolism" EXACT [] +xref: Wikipedia:Linoleic_acid +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0033559 ! unsaturated fatty acid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0043652 +name: engulfment of apoptotic cell +namespace: biological_process +def: "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015] +comment: This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'. +synonym: "engulfment of apoptotic cell corpse" EXACT [] +synonym: "engulfment of cell corpse" EXACT [] +is_a: GO:0006911 ! phagocytosis, engulfment +relationship: part_of GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:0043653 +name: mitochondrial fragmentation involved in apoptotic process +namespace: biological_process +def: "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994] +comment: Although most of the processes described under 'apoptotic mitochondrial changes' take place during the signaling phase of apoptosis, 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed there. It is still controversial whether this process is involved in the signaling phase of apoptosis or not, so it was placed under the more generic 'apoptotic mitochondrial changes' parent rather than linked to the signaling or the execution phase until further research clarifies the matter. +synonym: "mitochondrial fission during apoptosis" RELATED [GOC:dph, GOC:tb] +synonym: "mitochondrial fragmentation involved in apoptosis" NARROW [] +is_a: GO:0008637 ! apoptotic mitochondrial changes + +[Term] +id: GO:0043654 +name: recognition of apoptotic cell +namespace: biological_process +def: "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015] +synonym: "detection of apoptotic cell" EXACT [] +synonym: "detection of apoptotic cell corpse" EXACT [] +synonym: "detection of cell corpse" EXACT [] +synonym: "recognition of apoptotic cell corpse" EXACT [] +synonym: "recognition of cell corpse" EXACT [] +is_a: GO:0006910 ! phagocytosis, recognition +relationship: part_of GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:0043655 +name: host extracellular space +namespace: cellular_component +def: "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc] +synonym: "extracellular space of host" EXACT [] +is_a: GO:0018995 ! host cellular component + +[Term] +id: GO:0043656 +name: host intracellular region +namespace: cellular_component +def: "That space within the plasma membrane of a host cell." [GOC:cc] +synonym: "host intracellular" EXACT [] +synonym: "intracellular region of host" EXACT [] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0043657 +name: host cell +namespace: cellular_component +def: "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl] +is_a: GO:0018995 ! host cellular component + +[Term] +id: GO:0043658 +name: host symbiosome +namespace: cellular_component +def: "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0043659 +name: symbiosome +namespace: cellular_component +def: "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc] +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0043660 +name: bacteroid-containing symbiosome +namespace: cellular_component +def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc] +is_a: GO:0043659 ! symbiosome + +[Term] +id: GO:0043661 +name: peribacteroid membrane +namespace: cellular_component +def: "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] +is_a: GO:0030666 ! endocytic vesicle membrane +relationship: part_of GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0043662 +name: peribacteroid fluid +namespace: cellular_component +def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0043663 +name: host bacteroid-containing symbiosome +namespace: cellular_component +def: "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc] +is_a: GO:0043658 ! host symbiosome + +[Term] +id: GO:0043664 +name: host peribacteroid membrane +namespace: cellular_component +def: "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome + +[Term] +id: GO:0043665 +name: host peribacteroid fluid +namespace: cellular_component +def: "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0043663 ! host bacteroid-containing symbiosome + +[Term] +id: GO:0043666 +name: regulation of phosphoprotein phosphatase activity +namespace: biological_process +alt_id: GO:0032512 +alt_id: GO:0034047 +def: "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821] +synonym: "regulation of calcineurin activity" NARROW [] +synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] +synonym: "regulation of protein phosphatase type 2 activity" RELATED [GOC:dph, GOC:rl] +synonym: "regulation of protein phosphatase type 2A activity" NARROW [] +synonym: "regulation of protein phosphatase type 2B activity" NARROW [] +is_a: GO:0010921 ! regulation of phosphatase activity +is_a: GO:0035304 ! regulation of protein dephosphorylation + +[Term] +id: GO:0043667 +name: pollen wall +namespace: cellular_component +def: "The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine." [GOC:fz, PMID:15131249] +synonym: "microspore wall" EXACT [] +is_a: GO:0030312 ! external encapsulating structure + +[Term] +id: GO:0043668 +name: exine +namespace: cellular_component +def: "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the exine is highly resistant to strong acids and bases. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0043669 +name: ectexine +namespace: cellular_component +def: "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043670 +name: foot layer +namespace: cellular_component +def: "The inner layer of the ectexine." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "nexine 1" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043669 ! ectexine + +[Term] +id: GO:0043671 +name: endexine +namespace: cellular_component +def: "The inner part of the exine, which stains." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043672 +name: nexine +namespace: cellular_component +def: "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043673 +name: sexine +namespace: cellular_component +def: "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043668 ! exine + +[Term] +id: GO:0043674 +name: columella +namespace: cellular_component +def: "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "sexine 1" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043675 +name: sculpture element +namespace: cellular_component +def: "The third layer of the sexine." [http://www.mobot.org/MOBOT/research/APweb/] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043676 +name: tectum +namespace: cellular_component +def: "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/] +synonym: "sexine 2" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043673 ! sexine + +[Term] +id: GO:0043677 +name: obsolete germination pore +namespace: cellular_component +def: "OBSOLETE. A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore] +comment: This term was made obsolete because it was poorly named and poorly defined. +synonym: "germ pore" EXACT [] +xref: Wikipedia:Germ_pore +is_obsolete: true + +[Term] +id: GO:0043678 +name: intine +namespace: cellular_component +def: "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/] +comment: Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0043679 +name: axon terminus +namespace: cellular_component +def: "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl] +synonym: "axon terminal" EXACT [NIF_Subcellular:sao2007137787] +synonym: "axon terminal specialization" RELATED [] +synonym: "nerve ending" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090512 +is_a: GO:0044306 ! neuron projection terminus +is_a: GO:0098793 ! presynapse +relationship: part_of GO:0150034 ! distal axon + +[Term] +id: GO:0043680 +name: filiform apparatus +namespace: cellular_component +def: "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005618 ! cell wall + +[Term] +id: GO:0043682 +name: P-type divalent copper transporter activity +namespace: molecular_function +alt_id: GO:0004008 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [RHEA:10376] +synonym: "copper exporting ATPase activity" BROAD [] +synonym: "copper transmembrane transporter activity, phosphorylative mechanism" BROAD [] +synonym: "copper-exporting ATPase activity" NARROW [] +synonym: "copper-translocating P-type ATPase activity" BROAD [] +synonym: "copper-transporting ATPase activity" BROAD [] +synonym: "Cu(2+)-exporting ATPase activity" RELATED [EC:7.2.2.9] +synonym: "Cu2+-exporting ATPase activity" RELATED [EC:7.2.2.9] +xref: EC:7.2.2.9 +xref: MetaCyc:3.6.3.4-RXN +xref: Reactome:R-HSA-3697838 "ATP7A transfers Cu from ATOX1 to SOD3" +xref: Reactome:R-HSA-6803545 "ATP7A transports cytosolic Cu2+ to phagosomal lumen" +xref: Reactome:R-HSA-936802 "ATP7A transports cytosolic Cu2+ to extracellular region" +xref: Reactome:R-HSA-936895 "ATP7B transports cytosolic Cu2+ to Golgi lumen" +xref: RHEA:10376 +is_a: GO:0005375 ! copper ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0043683 +name: type IV pilus assembly +namespace: biological_process +def: "The assembly from its constituent parts of a type IV pilus." [GOC:jl, GOC:ml, PMID:31784891] +synonym: "type IV fimbria assembly" EXACT [] +synonym: "type IV fimbria biogenesis" EXACT [] +synonym: "type IV fimbriae assembly" EXACT [] +synonym: "type IV fimbriae biogenesis" EXACT [] +synonym: "type IV fimbrial assembly" EXACT [] +synonym: "type IV fimbrial biogenesis" EXACT [] +synonym: "type IV fimbrium assembly" EXACT [] +synonym: "type IV fimbrium biogenesis" EXACT [] +synonym: "type IV pilus biogenesis" RELATED [] +is_a: GO:0009297 ! pilus assembly + +[Term] +id: GO:0043684 +name: type IV secretion system complex +namespace: cellular_component +def: "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml] +synonym: "T4SS complex" EXACT [] +synonym: "type IV protein secretion system complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0043685 +name: conversion of glutamyl-tRNA to glutaminyl-tRNA +namespace: biological_process +def: "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308] +comment: Note that this process has been observed in some archaeal and bacterial species. +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0043686 +name: co-translational protein modification +namespace: biological_process +def: "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg] +comment: This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome. +synonym: "co-translational amino acid modification" EXACT [] +synonym: "co-translational modification" EXACT [] +synonym: "cotranslational amino acid modification" EXACT [] +synonym: "cotranslational modification" EXACT [] +synonym: "cotranslational protein modification" EXACT [] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0043687 +name: post-translational protein modification +namespace: biological_process +def: "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg] +comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term. +synonym: "post-translational amino acid modification" EXACT [] +synonym: "post-translational modification" EXACT [] +synonym: "posttranslational amino acid modification" EXACT [] +synonym: "posttranslational modification" EXACT [] +synonym: "posttranslational protein modification" EXACT [] +synonym: "PTM" EXACT [] +xref: Wikipedia:Posttranslational_modification +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0043688 +name: conversion of aspartyl-tRNA to asparaginyl-tRNA +namespace: biological_process +def: "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001] +comment: Note that this process has been observed in some archaeal and bacterial species. +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0043691 +name: reverse cholesterol transport +namespace: biological_process +def: "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809] +is_a: GO:0030301 ! cholesterol transport + +[Term] +id: GO:0043692 +name: monoterpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene] +synonym: "monoterpene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0043693 +name: monoterpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [Wikipedia:Monoterpene] +synonym: "monoterpene biosynthesis" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:0046246 ! terpene biosynthetic process + +[Term] +id: GO:0043694 +name: monoterpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [PMID:25076942] +synonym: "monoterpene catabolism" EXACT [] +is_a: GO:0043692 ! monoterpene metabolic process +is_a: GO:0046247 ! terpene catabolic process + +[Term] +id: GO:0043695 +name: detection of pheromone +namespace: biological_process +def: "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0019236 ! response to pheromone + +[Term] +id: GO:0043696 +name: dedifferentiation +namespace: biological_process +def: "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg] +xref: Wikipedia:Cellular_differentiation#Dedifferentiation +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0043697 +name: cell dedifferentiation +namespace: biological_process +def: "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg] +comment: Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer. +is_a: GO:0043696 ! dedifferentiation +is_a: GO:0048869 ! cellular developmental process + +[Term] +id: GO:0043698 +name: iridosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh] +synonym: "reflecting platelet" EXACT [] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043699 +name: leucosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh] +synonym: "refractosome" EXACT [] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043700 +name: pterinosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043701 +name: cyanosome +namespace: cellular_component +def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh] +is_a: GO:0048770 ! pigment granule + +[Term] +id: GO:0043702 +name: carotenoid vesicle +namespace: cellular_component +def: "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0043703 +name: photoreceptor cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu] +is_a: GO:0048664 ! neuron fate determination +relationship: part_of GO:0046552 ! photoreceptor cell fate commitment + +[Term] +id: GO:0043704 +name: photoreceptor cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu] +is_a: GO:0048665 ! neuron fate specification +relationship: part_of GO:0046552 ! photoreceptor cell fate commitment + +[Term] +id: GO:0043705 +name: cyanophycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl] +synonym: "cyanophycin metabolism" EXACT [] +synonym: "multi-L-arginyl-poly(L-aspartic acid) metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0043707 +name: cell adhesion involved in single-species biofilm formation in or on host organism +namespace: biological_process +def: "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species." [GOC:jl] +synonym: "cell adhesion during single-species biofilm formation in or on host organism" RELATED [GOC:dph] +is_a: GO:0043709 ! cell adhesion involved in single-species biofilm formation +relationship: part_of GO:0044407 ! single-species biofilm formation in or on host organism + +[Term] +id: GO:0043708 +name: cell adhesion involved in biofilm formation +namespace: biological_process +def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb] +synonym: "cell adhesion during biofilm formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0031589 ! cell-substrate adhesion +relationship: part_of GO:0090605 ! submerged biofilm formation + +[Term] +id: GO:0043709 +name: cell adhesion involved in single-species biofilm formation +namespace: biological_process +def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb] +synonym: "cell adhesion during single-species biofilm formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043708 ! cell adhesion involved in biofilm formation +relationship: part_of GO:0090609 ! single-species submerged biofilm formation + +[Term] +id: GO:0043710 +name: cell adhesion involved in multi-species biofilm formation +namespace: biological_process +def: "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb] +synonym: "cell adhesion during multi-species biofilm formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043708 ! cell adhesion involved in biofilm formation +relationship: part_of GO:0044399 ! multi-species biofilm formation + +[Term] +id: GO:0043711 +name: pilus organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl] +comment: Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction. +subset: gocheck_do_not_annotate +synonym: "pilus organisation" EXACT [GOC:mah] +synonym: "pilus organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0043712 +name: 2-hydroxyisocaproate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate." [PMID:16957230] +synonym: "(R)-2-hydroxyisocaproate CoA transferase activity" EXACT [] +synonym: "(R)-2-hydroxyisocaproate CoA-transferase activity" EXACT [] +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043713 +name: (R)-2-hydroxyisocaproate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043714 +name: (R)-citramalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346] +synonym: "citramalate synthase" BROAD [] +xref: EC:2.3.1.182 +xref: MetaCyc:RXN-7743 +xref: RHEA:19045 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0043715 +name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN] +comment: This function is part of the process of methionine salvage. +synonym: "DK-MTP-1-P enolase activity" EXACT [] +synonym: "E-1" RELATED [] +synonym: "MasA" RELATED [] +synonym: "mtnW" RELATED [] +xref: EC:5.3.2.5 +xref: MetaCyc:R82-RXN +xref: RHEA:18769 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0043716 +name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, MetaCyc:R83-RXN] +synonym: "2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity" EXACT [MetaCyc:R83-RXN] +synonym: "HK-MTPenyl-1-P phosphatase activity" EXACT [] +xref: KEGG_REACTION:R07394 +xref: MetaCyc:R83-RXN +xref: RHEA:14481 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043717 +name: 2-hydroxyglutaryl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA." [MetaCyc:RXN-1083] +synonym: "(R)-2-hydroxyglutaryl-CoA dehydratase activity" EXACT [] +xref: MetaCyc:RXN-1083 +xref: RHEA:42448 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043718 +name: 2-hydroxymethylglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH." [EC:1.1.1.291, RHEA:15505] +synonym: "(S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.291] +synonym: "HgD" EXACT [] +xref: EC:1.1.1.291 +xref: KEGG_REACTION:R07985 +xref: MetaCyc:1.1.1.291-RXN +xref: RHEA:15505 +xref: Wikipedia:2-hydroxymethylglutarate_dehydrogenase +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043719 +name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] +xref: EC:1.14.13.- +xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043720 +name: 3-keto-5-aminohexanoate cleavage activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064] +synonym: "3-keto-5-aminohexanoate cleavage enzyme" EXACT [] +xref: MetaCyc:R125-RXN +xref: RHEA:31555 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043721 +name: 4-hydroxybutanoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O." [EC:4.2.1.120] +synonym: "4-hydroxybutanoyl-CoA hydro-lyase" EXACT [] +synonym: "4-hydroxybutyryl-CoA dehydratase activity" EXACT [] +synonym: "gamma-hydroxybutanoyl-CoA dehydratase activity" EXACT [] +synonym: "gamma-hydroxybutyryl-CoA dehydratase activity" EXACT [] +xref: EC:4.2.1.120 +xref: KEGG_REACTION:R05337 +xref: MetaCyc:RXN-8890 +xref: RHEA:26530 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043722 +name: 4-hydroxyphenylacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2)." [EC:4.1.1.83, RHEA:22732] +synonym: "4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming)" RELATED [EC:4.1.1.83] +synonym: "4-Hpd activity" RELATED [EC:4.1.1.83] +synonym: "4-hydroxyphenylacetate carboxy-lyase activity" RELATED [EC:4.1.1.83] +synonym: "p-Hpd activity" RELATED [EC:4.1.1.83] +synonym: "p-hydroxyphenylacetate decarboxylase activity" RELATED [EC:4.1.1.83] +xref: EC:4.1.1.83 +xref: KEGG_REACTION:R07312 +xref: MetaCyc:4.1.1.83-RXN +xref: RHEA:22732 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0043723 +name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity +namespace: molecular_function +alt_id: GO:0017173 +def: "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103] +synonym: "2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity" EXACT [MetaCyc:YOL066C-MONOMER] +synonym: "DRAP deaminase activity" EXACT [] +xref: MetaCyc:RXN-10058 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0043724 +name: 2-keto-3-deoxygalactonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170] +synonym: "KDGal aldolase activity" EXACT [] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043726 +name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity +namespace: molecular_function +alt_id: GO:0019173 +def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl] +synonym: "pyrimidine phosphatase activity" EXACT [GOC:mah] +xref: MetaCyc:RIBOPHOSPHAT-RXN +xref: RHEA:25197 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043727 +name: 5-amino-4-imidazole carboxylate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl] +xref: EC:4.1.1.21 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0043728 +name: 2-keto-4-methylthiobutyrate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl] +xref: EC:4.1.1.- +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043729 +name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H+." [RHEA:27282] +xref: EC:3.5.1.102 +xref: RHEA:27282 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043730 +name: 5-ureido-4-imidazole carboxylate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl] +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0043731 +name: 6-hydroxynicotinate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591] +xref: EC:1.14.13.114 +xref: MetaCyc:RXN-7573 +xref: RHEA:27333 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043732 +name: 6-hydroxynicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2)." [EC:1.17.3.3, RHEA:22808] +synonym: "6-hydroxynicotinate hydroxylase activity" RELATED [EC:1.17.3.3] +synonym: "6-hydroxynicotinate:O2 oxidoreductase activity" RELATED [EC:1.17.3.3] +synonym: "6-hydroxynicotinic acid dehydrogenase activity" RELATED [EC:1.17.3.3] +synonym: "6-hydroxynicotinic acid hydroxylase activity" RELATED [EC:1.17.3.3] +xref: EC:1.17.3.3 +xref: KEGG_REACTION:R07221 +xref: MetaCyc:RXN-7585 +xref: RHEA:22808 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0043733 +name: DNA-3-methylbase glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site." [PMID:10777493, PMID:14517230] +synonym: "DNA-3-methyladenine glycosylase III" RELATED [] +synonym: "Mag III" NARROW [] +synonym: "MagIII" NARROW [] +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0043734 +name: DNA-N1-methyladenine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde." [PMID:19786499] +synonym: "AlkB" NARROW [] +synonym: "alpha-ketoglutarate-dependent dioxygenase" NARROW [] +xref: Reactome:R-HSA-112118 "Oxidative demethylation of 1-meA damaged DNA by ALKBH2" +xref: Reactome:R-HSA-112123 "Oxidative demethylation of 1-meA damaged DNA By ALKBH3" +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0043736 +name: obsolete DNA-3-methyladenine glycosylase IV activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [PMID:10375529] +comment: This term was made obsolete because it represents an enzyme with four different activities. +synonym: "DNA-3-methyladenine glycosylase IV activity" EXACT [] +synonym: "Mpg II" NARROW [] +synonym: "MpgII" NARROW [] +is_obsolete: true +consider: GO:0008725 +consider: GO:0043916 +consider: GO:0052821 +consider: GO:0052822 + +[Term] +id: GO:0043737 +name: deoxyribonuclease V activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7] +synonym: "DNase V activity" RELATED [EC:3.1.21.7] +synonym: "endodeoxyribonuclease V" EXACT [] +synonym: "endonuclease V activity" BROAD [EC:3.1.21.7] +synonym: "Escherichia coli endodeoxyribonuclease V activity" NARROW [EC:3.1.21.7] +xref: EC:3.1.21.7 +xref: MetaCyc:3.1.21.7-RXN +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0043738 +name: reduced coenzyme F420 dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420." [MetaCyc:RXN-8106] +synonym: "1,5-dihydrocoenzyme F420 dehydrogenase activity" EXACT [CHEBI:15823] +synonym: "F420H2 dehydrogenase activity" EXACT [] +xref: EC:1.5.98.3 +xref: MetaCyc:RXN-8106 +xref: RHEA:54752 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043739 +name: G/U mismatch-specific uracil-DNA glycosylase activity +namespace: molecular_function +def: "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [PMID:24739389] +synonym: "GU mismatch-specific uracil-DNA glycosylase activity" EXACT [] +synonym: "MUG" EXACT [] +synonym: "uracil mismatch repair protein" BROAD [] +is_a: GO:0004844 ! uracil DNA N-glycosylase activity +is_a: GO:0008263 ! pyrimidine-specific mismatch base pair DNA N-glycosylase activity + +[Term] +id: GO:0043740 +name: GTP cyclohydrolase IIa activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate." [EC:3.5.4.29, RHEA:22468] +synonym: "GTP 8,9-dihydrolase (phosphate-forming)" RELATED [EC:3.5.4.29] +synonym: "GTP 8,9-hydrolase (phosphate-forming)" EXACT [] +synonym: "GTP cyclohydrolase III activity" NARROW [EC:3.5.4.29] +xref: EC:3.5.4.29 +xref: KEGG_REACTION:R07306 +xref: MetaCyc:RXN-10055 +xref: RHEA:22468 +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0043741 +name: alpha-aminoadipate acetyltransferase activity +namespace: molecular_function +alt_id: GO:0043869 +def: "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [PMID:10613839, PMID:12925802, PMID:29053735] +synonym: "L-2-aminoadipate N-acetyltransferase activity" RELATED [] +xref: MetaCyc:RXN-5181 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0043743 +name: LPPG:FO 2-phospho-L-lactate transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [PMID:11888293] +xref: EC:2.7.8.28 +xref: RHEA:27510 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043744 +name: N2-acetyl-L-aminoadipate kinase activity +namespace: molecular_function +alt_id: GO:0043868 +def: "Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate." [PMID:25392000, PMID:26966182, RHEA:41944] +synonym: "[LysW]-aminoadipate kinase" RELATED [] +synonym: "acetylaminoadipate kinase activity" EXACT [] +synonym: "N-acetyl-L-aminoadipate 5-phosphotransferase activity" EXACT [] +synonym: "N-acetylaminoadipate kinase activity" EXACT [] +xref: MetaCyc:RXN-5182 +xref: RHEA:41944 +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0043745 +name: obsolete N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449] +comment: This term was obsoleted because there is no evidence that it exists. +is_obsolete: true + +[Term] +id: GO:0043746 +name: obsolete N2-acetyl-L-lysine aminotransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450] +comment: This term was obsoleted because there is no evidence that it exists. +synonym: "N-acetyl-lysine aminotransferase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043747 +name: obsolete N2-acetyl-L-lysine deacetylase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine." [RHEA:28598] +comment: This term was obsoleted because there is no evidence that it exists. +synonym: "N-acetyl-lysine deacetylase activity" EXACT [] +xref: MetaCyc:RXN-5185 +xref: RHEA:28598 +is_obsolete: true + +[Term] +id: GO:0043748 +name: O-succinylbenzoate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [PMID:8335646] +xref: EC:4.2.1.113 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043749 +name: phenol, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277] +synonym: "ATP:phenol:water phosphotransferase activity" EXACT [] +synonym: "phenol:water dikinase activity" EXACT [] +synonym: "phenylphosphate synthase activity" EXACT [] +xref: EC:2.7.9.- +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0043750 +name: phosphatidylinositol alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.345] +synonym: "GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [] +synonym: "GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] +synonym: "GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] +synonym: "GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity" EXACT [] +synonym: "guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity" EXACT [] +synonym: "phosphatidyl-myo-inositol alpha-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.345 +xref: MetaCyc:2.4.1.57-RXN +xref: RHEA:47368 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0043751 +name: polyphosphate:AMP phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP." [PMID:11237733] +synonym: "PAP" EXACT [] +synonym: "PPT" BROAD [] +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0043752 +name: adenosylcobinamide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156] +synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] +synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] +synonym: "CobU" RELATED [] +synonym: "RTP:adenosylcobinamide phosphotransferase activity" EXACT [] +xref: EC:2.7.1.156 +xref: MetaCyc:2.7.1.156-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043754 +name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168] +synonym: "2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" RELATED [EC:2.3.1.168] +synonym: "2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity" RELATED [EC:2.3.1.168] +synonym: "dihydrolipoyl transacylase activity" RELATED [EC:2.3.1.168] +synonym: "enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity" EXACT [] +xref: EC:2.3.1.168 +xref: MetaCyc:2.3.1.168-RXN +xref: RHEA:18865 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043755 +name: alpha-ribazole phosphatase activity +namespace: molecular_function +alt_id: GO:0019175 +def: "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate." [EC:3.1.3.73, RHEA:24456] +synonym: "alpha-ribazole-5'-P phosphatase activity" EXACT [] +synonym: "alpha-ribazole-5'-phosphate phosphohydrolase activity" EXACT [] +synonym: "CobC" RELATED [] +xref: EC:3.1.3.73 +xref: KEGG_REACTION:R04594 +xref: MetaCyc:RIBAZOLEPHOSPHAT-RXN +xref: RHEA:24456 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043756 +name: adenosylcobinamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23504] +synonym: "adenosylcobinamide amidohydrolase activity" RELATED [EC:3.5.1.90] +synonym: "AdoCbi amidohydrolase activity" RELATED [EC:3.5.1.90] +synonym: "AdoCbi hydrolase activity" RELATED [EC:3.5.1.90] +synonym: "CbiZ" RELATED [] +xref: EC:3.5.1.90 +xref: KEGG_REACTION:R05226 +xref: MetaCyc:R346-RXN +xref: RHEA:23504 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043757 +name: adenosylcobinamide-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10] +synonym: "adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)" EXACT [] +synonym: "AdoCbi-P synthase activity" RELATED [EC:6.3.1.10] +synonym: "CbiB" RELATED [] +xref: EC:6.3.1.10 +xref: MetaCyc:RXN-6261 +xref: RHEA:21896 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0043758 +name: acetate-CoA ligase (ADP-forming) activity +namespace: molecular_function +alt_id: GO:0043762 +def: "Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA." [RHEA:15081] +synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.13] +synonym: "acetate--CoA ligase (ADP-forming) activity" EXACT [] +synonym: "acetate:CoA ligase (ADP-forming)" RELATED [] +synonym: "acetyl coenzyme A synthetase (adenosine diphosphate-forming)" EXACT [] +synonym: "acetyl-CoA synthetase (ADP-forming) activity" RELATED [EC:6.2.1.13] +synonym: "aryl-CoA synthetase (ADP-forming) activity" RELATED [] +xref: EC:6.2.1.13 +xref: MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN +xref: RHEA:15081 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043759 +name: methylbutanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA." [RHEA:46180] +synonym: "branched chain acyl CoA synthetase (ADP-forming) activity" EXACT [] +synonym: "branched chain acyl-CoA synthetase (ADP-forming) activity" EXACT [] +synonym: "branched-chain acyl CoA synthetase (ADP-forming) activity" EXACT [] +synonym: "branched-chain acyl-CoA synthetase (ADP-forming) activity" RELATED [] +xref: RHEA:46180 +is_a: GO:0031956 ! medium-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0043760 +name: acetyldiaminopimelate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [PMID:1906065] +synonym: "N-acetyl-diaminopimelate aminotransferase activity" EXACT [] +synonym: "N-acetyl-L,L-diaminopimelate aminotransferase activity" EXACT [] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043761 +name: archaetidylserine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [PMID:12562787] +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity" EXACT [] +synonym: "CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity" EXACT [] +xref: EC:2.7.8.38 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0043763 +name: UTP:glucose-1-phosphate uridylyltransferase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of UTP:glucose-1-phosphate uridylyltransferase." [GOC:jl] +synonym: "glucose-1-phosphate uridylyltransferase regulator activity" EXACT [] +synonym: "UDP-glucose diphosphorylase regulator activity" EXACT [] +synonym: "UDP-glucose pyrophosphorylase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0043765 +name: T/G mismatch-specific endonuclease activity +namespace: molecular_function +def: "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [PMID:17651368] +synonym: "DNA mismatch endonuclease" BROAD [] +synonym: "V.EcoKDcm" RELATED [] +synonym: "very short patch repair protein" RELATED [] +synonym: "Vsr mismatch endonuclease" RELATED [] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0043766 +name: Sep-tRNA:Cys-tRNA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate." [PMID:15790858, PMID:16380427, PMID:17110438] +synonym: "O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity" EXACT [] +synonym: "Sep-tRNA:Cys-tRNA synthetase activity" EXACT [] +synonym: "SepCysS" RELATED [] +xref: EC:2.5.1.73 +xref: MetaCyc:RXN-10719 +xref: RHEA:25686 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043767 +name: pyrrolysyl-tRNA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [PMID:15314242, RHEA:19277] +synonym: "PylRS" EXACT [] +synonym: "pyrrolysine-tRNA ligase activity" EXACT [] +xref: EC:6.1.1.26 +xref: MetaCyc:6.1.1.26-RXN +xref: RHEA:19277 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0043768 +name: S-ribosylhomocysteine lyase activity +namespace: molecular_function +alt_id: GO:0019138 +def: "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [RHEA:17753] +synonym: "LuxS" RELATED [] +synonym: "ribosylhomocysteinase activity" EXACT [] +synonym: "S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]" RELATED [EC:4.4.1.21] +synonym: "S-ribosylhomocysteinase activity" EXACT [] +xref: EC:4.4.1.21 +xref: KEGG_REACTION:R01291 +xref: MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN +xref: RHEA:17753 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0043769 +name: Tpg-containing telomere binding complex +namespace: cellular_component +def: "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591] +synonym: "telomere complex" BROAD [] +is_a: GO:0000782 ! telomere cap complex + +[Term] +id: GO:0043770 +name: demethylmenaquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [PMID:1444716, PMID:9045837] +xref: EC:2.1.1.163 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043771 +name: cytidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cytidine = ADP + CMP." [PMID:211379] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019206 ! nucleoside kinase activity + +[Term] +id: GO:0043772 +name: acyl-phosphate glycerol-3-phosphate acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [PMID:17308305] +synonym: "acyl-phosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "acylphosphate glycerol-3-phosphate acyltransferase activity" EXACT [] +synonym: "acylphosphate:glycerol-3-phosphate acyltransferase activity" EXACT [] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043773 +name: coenzyme F420-0 gamma-glutamyl ligase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [PMID:17669425] +synonym: "F420-0 gamma-glutamyl ligase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0043774 +name: coenzyme F420-2 alpha-glutamyl ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [PMID:12909715] +synonym: "F420-2 alpha-glutamyl ligase activity" EXACT [] +xref: EC:6.3.2.32 +xref: RHEA:42332 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0043776 +name: cobalt-precorrin-6B C5-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [MetaCyc:RXN-8766] +synonym: "cobalt-precorrin 6B C5-methyltransferase activity" EXACT [] +synonym: "precorrin-6 methyltransferase activity" EXACT [] +synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] +synonym: "precorrin-6Y methylase" BROAD [] +xref: MetaCyc:RXN-8766 +xref: RHEA:36067 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043777 +name: cobalt-precorrin-7 C15-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [MetaCyc:RXN-8767] +synonym: "cobalt-precorrin 7 C15-methyltransferase activity" EXACT [] +synonym: "precorrin-6 methyltransferase" BROAD [] +synonym: "precorrin-6Y C5,15-methyltransferase (decarboxylating)" BROAD [] +synonym: "precorrin-6Y methylase" BROAD [] +xref: MetaCyc:RXN-8767 +xref: RHEA:34591 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043778 +name: cobalt-precorrin-8 methylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate." [MetaCyc:RXN-8768] +synonym: "cobalt-precorrin 8 methylmutase activity" EXACT [] +synonym: "cobalt-precorrin 8X methylmutase activity" EXACT [] +synonym: "cobalt-precorrin-8X methylmutase activity" EXACT [] +xref: EC:5.4.99.60 +xref: MetaCyc:RXN-8768 +xref: RHEA:16209 +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0043779 +name: cobalt-precorrin-5A acetaldehyde-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde + H+." [RHEA:26281] +synonym: "cobalt-precorrin 5A acetaldehyde-lyase activity" EXACT [] +xref: EC:3.7.1.12 +xref: MetaCyc:RXN-8763 +xref: RHEA:26281 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0043780 +name: cobalt-precorrin-5B C1-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [MetaCyc:RXN-8764] +synonym: "cobalt-precorrin 5B C1-methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-8764 +xref: RHEA:26285 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043781 +name: cobalt-factor II C20-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151] +synonym: "CbiL" NARROW [] +synonym: "cobalt-factor II C20 methyltransferase activity" EXACT [] +synonym: "cobalt-precorrin-2 C(20)-methyltransferase activity" RELATED [EC:2.1.1.151] +synonym: "S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity" RELATED [EC:2.1.1.151] +xref: EC:2.1.1.151 +xref: MetaCyc:RXN-8760 +xref: RHEA:17997 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043782 +name: cobalt-precorrin-3 C17-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [MetaCyc:RXN-8761] +synonym: "cobalt-precorrin 3 C17-methyltransferase activity" EXACT [] +synonym: "cobalt-precorrin-3 methylase" BROAD [] +synonym: "cobalt-precorrin-3 methyltransferase" BROAD [] +synonym: "cobalt-precorrin-3B C17-methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-8761 +xref: RHEA:26273 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043783 +name: oxidoreductase activity, acting on metal ions, flavin as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor." [EC:1.16.8.-] +synonym: "oxidoreductase activity, oxidizing metal ions with flavin as acceptor" RELATED [] +synonym: "oxidoreductase activity, reducing metal ions, flavin as acceptor" RELATED [] +xref: EC:1.16.8.- +is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions + +[Term] +id: GO:0043784 +name: cob(II)yrinic acid a,c-diamide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2)." [EC:1.16.8.1, RHEA:24300] +synonym: "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity" EXACT [] +xref: EC:1.16.8.1 +xref: KEGG_REACTION:R05218 +xref: MetaCyc:R343-RXN +xref: RHEA:24300 +is_a: GO:0043783 ! oxidoreductase activity, acting on metal ions, flavin as acceptor + +[Term] +id: GO:0043785 +name: cinnamoyl-CoA:phenyllactate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15601] +synonym: "(E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity" EXACT [] +synonym: "FldA" RELATED [] +xref: EC:2.8.3.17 +xref: KEGG_REACTION:R07796 +xref: MetaCyc:2.8.3.17-RXN +xref: RHEA:15601 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043786 +name: cinnamate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [PMID:10849007] +xref: EC:1.3.1.- +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043791 +name: dimethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [PMID:9874228] +comment: This function is the first step in the pathway of methanogenesis from dimethylamine. +synonym: "dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +synonym: "dimethylamine:corrinoid methyltransferase activity" EXACT [] +synonym: "DMA methyltransferase 1" EXACT [] +synonym: "DMAMT 1" EXACT [] +synonym: "MT1" BROAD [] +synonym: "mtbB1" RELATED [] +xref: EC:2.1.1.249 +xref: MetaCyc:RXN-8100 +xref: RHEA:41175 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043792 +name: enamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+)." [EC:3.5.2.18, RHEA:17209] +synonym: "6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity" EXACT [] +xref: EC:3.5.2.18 +xref: KEGG_REACTION:R07984 +xref: MetaCyc:3.5.2.18-RXN +xref: RHEA:17209 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043793 +name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate." [GOC:jl, PMID:12142414] +synonym: "beta-RFAP synthase activity" EXACT [] +xref: MetaCyc:RXN-8124 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0043794 +name: formate dehydrogenase (coenzyme F420) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [PMID:3801411] +synonym: "formate dehydrogenase (F420) activity" EXACT [] +xref: EC:1.2.99.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0043795 +name: glyceraldehyde oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+)." [PMID:10095793, RHEA:36047] +xref: EC:1.2.99.8 +xref: RHEA:36047 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0043796 +name: glyceraldehyde dehydrogenase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+." [EC:1.2.1.89] +xref: EC:1.2.1.89 +xref: RHEA:40163 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043797 +name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [PMID:11265456, PMID:7721730, RHEA:24148] +synonym: "D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity" EXACT [] +synonym: "GAPOR" RELATED [] +synonym: "glyceraldehyde-3-phosphate Fd oxidoreductase activity" RELATED [EC:1.2.7.6] +synonym: "glyceraldehyde-3-phosphate ferredoxin reductase activity" RELATED [EC:1.2.7.6] +xref: EC:1.2.7.6 +xref: MetaCyc:1.2.7.6-RXN +xref: RHEA:24148 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043798 +name: glycerate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [PMID:14413719, RHEA:27377] +synonym: "D-glycerate 2-kinase activity" EXACT [] +synonym: "glycerate kinase" BROAD [] +xref: EC:2.7.1.165 +xref: MetaCyc:GKI-RXN +xref: RHEA:27377 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0043799 +name: glycine oxidase activity +namespace: molecular_function +def: "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19] +synonym: "glycine:oxygen oxidoreductase (deaminating)" EXACT [] +xref: EC:1.4.3.19 +xref: MetaCyc:1.4.3.19-RXN +xref: MetaCyc:RXN-8672 +xref: MetaCyc:RXN-8673 +xref: MetaCyc:RXN-8674 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0043800 +name: hexulose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [MetaCyc:R12-RXN, PMID:11839305] +synonym: "HUMPI" EXACT [] +xref: EC:5.3.1.27 +xref: MetaCyc:R12-RXN +xref: RHEA:25900 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0043801 +name: hexulose-6-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [PMID:16075199] +xref: EC:4.1.2.43 +xref: MetaCyc:R10-RXN +xref: RHEA:25201 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043802 +name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12544] +synonym: "CobB" RELATED [] +synonym: "hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity" EXACT [] +synonym: "hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)" EXACT [] +xref: EC:6.3.5.9 +xref: KEGG_REACTION:R05224 +xref: MetaCyc:R341-RXN +xref: RHEA:12544 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0043803 +name: hydroxyneurosporene-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene." [PMID:12664193, PMID:12770713, PMID:7358679, RHEA:30903] +synonym: "1-HO-carotenoid methylase" RELATED [EC:2.1.1.210] +synonym: "1-hydroxycarotenoid methylase" RELATED [EC:2.1.1.210] +synonym: "1-hydroxycarotenoid O-methylase" RELATED [EC:2.1.1.210] +synonym: "demethylspheroidene O-methyltransferase" RELATED [EC:2.1.1.210] +xref: EC:2.1.1.210 +xref: RHEA:30903 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043804 +name: imidazolone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one." [PMID:27286964, RHEA:24935] +comment: Note that this reaction can occur spontaneously (see RHEA:24937). +xref: RHEA:24935 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043805 +name: indolepyruvate ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8] +synonym: "3-(indol-3-yl)pyruvate synthase (ferredoxin) activity" RELATED [EC:1.2.7.8] +synonym: "3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)" RELATED [EC:1.2.7.8] +synonym: "indolepyruvate oxidoreductase activity" RELATED [EC:1.2.7.8] +synonym: "IOR" RELATED [] +xref: EC:1.2.7.8 +xref: MetaCyc:1.2.7.8-RXN +xref: RHEA:12645 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043806 +name: keto acid formate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN] +synonym: "keto-acid formate acetyltransferase" BROAD [] +synonym: "keto-acid formate lyase activity" EXACT [] +synonym: "keto-acid formate-lyase activity" EXACT [] +xref: EC:2.3.1.- +xref: MetaCyc:KETOBUTFORMLY-RXN +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043807 +name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7] +synonym: "2-ketoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "2-oxoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "3-methyl-2-oxobutanoate synthase (ferredoxin) activity" RELATED [EC:1.2.7.7] +synonym: "3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)" EXACT [] +synonym: "branched-chain ketoacid ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "branched-chain oxo acid ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "keto-valine-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.7] +synonym: "ketoisovalerate ferredoxin reductase activity" RELATED [EC:1.2.7.7] +synonym: "ketoisovalerate oxidoreductase activity" RELATED [EC:1.2.7.7] +synonym: "VOR" RELATED [] +xref: EC:1.2.7.7 +xref: MetaCyc:1.2.7.7-RXN +xref: RHEA:11712 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043808 +name: lyso-ornithine lipid acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [PMID:15341653] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0043810 +name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids." [PMID:15341653, RHEA:20633] +synonym: "L-ornithine N(alpha)-acyltransferase" EXACT [] +synonym: "ornithine-acyl[acyl carrier protein] N-acyltransferase activity" EXACT [] +xref: EC:2.3.2.30 +xref: RHEA:20633 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0043811 +name: phosphate:acyl-[acyl carrier protein] acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a fatty acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [RHEA:42292] +xref: EC:2.3.1.274 +xref: RHEA:42292 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043812 +name: phosphatidylinositol-4-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [PMID:10224048] +synonym: "phosphatidylinositol 4-phosphate phosphatase activity" EXACT [] +is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity +is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity + +[Term] +id: GO:0043813 +name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [PMID:10806194, PMID:16607019] +synonym: "phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity" EXACT [] +xref: Reactome:R-HSA-1675836 "PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane" +xref: Reactome:R-HSA-1676005 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane" +xref: Reactome:R-HSA-1676020 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane" +xref: Reactome:R-HSA-1676174 "PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane" +is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity +is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity + +[Term] +id: GO:0043814 +name: phospholactate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [PMID:18260642] +xref: EC:2.7.7.68 +xref: MetaCyc:RXN-8077 +xref: RHEA:30519 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0043815 +name: phosphoribosylglycinamide formyltransferase 2 activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [EC:2.1.2.2, PMID:8117714] +synonym: "5'-phosphoribosylglycinamide transformylase 2" EXACT [] +synonym: "formate-dependent GAR transformylase activity" EXACT [] +synonym: "GAR transformylase 2" RELATED [] +synonym: "GART 2" RELATED [] +xref: MetaCyc:GARTRANSFORMYL2-RXN +xref: RHEA:24829 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0043816 +name: phosphoserine-tRNA(Cys) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [PMID:17110438, RHEA:25678] +synonym: "O-phosphoseryl-tRNA(Cys) synthetase activity" EXACT [] +synonym: "phosphoserine--tRNA(Cys) ligase activity" EXACT [] +synonym: "phosphoserine-tRNACys ligase activity" EXACT [] +synonym: "SepRS" RELATED [] +xref: EC:6.1.1.27 +xref: RHEA:25678 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0043817 +name: phosphosulfolactate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22784] +synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)" RELATED [EC:4.4.1.19] +synonym: "(2R)-O-phospho-3-sulfolactate sulfo-lyase activity" EXACT [] +synonym: "(2R)-phospho-3-sulfolactate synthase activity" RELATED [EC:4.4.1.19] +synonym: "PSL synthase activity" RELATED [EC:4.4.1.19] +xref: EC:4.4.1.19 +xref: KEGG_REACTION:R07476 +xref: MetaCyc:4.4.1.19-RXN +xref: MetaCyc:R228-RXN +xref: RHEA:22784 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0043818 +name: precorrin-3B synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B." [EC:1.14.13.83, RHEA:17293] +synonym: "CobG" RELATED [] +synonym: "precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)" EXACT [] +synonym: "precorrin-3X synthase activity" RELATED [EC:1.14.13.83] +xref: EC:1.14.13.83 +xref: KEGG_REACTION:R05217 +xref: MetaCyc:R321-RXN +xref: RHEA:17293 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0043819 +name: precorrin-6A synthase (deacetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X." [EC:2.1.1.152, RHEA:18261] +synonym: "CobF" RELATED [] +synonym: "precorrin-6X synthase (deacetylating) activity" RELATED [EC:2.1.1.152] +synonym: "S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)" EXACT [] +xref: EC:2.1.1.152 +xref: KEGG_REACTION:R05219 +xref: MetaCyc:R322-RXN +xref: RHEA:18261 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043820 +name: propionyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323] +xref: EC:1.3.99.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0043821 +name: propionyl-CoA:succinate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [PMID:10769117] +synonym: "propionyl-CoA succinate CoA-transferase activity" EXACT [] +synonym: "propionyl-CoA:succinate CoA transferase activity" EXACT [] +xref: MetaCyc:RXN0-268 +xref: RHEA:28010 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043822 +name: ribonuclease M5 activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [PMID:402365] +synonym: "5S ribosomal maturation nuclease activity" RELATED [EC:3.1.26.8] +synonym: "5S ribosomal RNA maturation endonuclease activity" EXACT [] +synonym: "RNase M5 activity" RELATED [EC:3.1.26.8] +xref: EC:3.1.26.8 +xref: MetaCyc:3.1.26.8-RXN +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0043823 +name: spheroidene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [PMID:16086104, PMID:16158287] +xref: EC:1.14.15.9 +xref: MetaCyc:RXN-10670 +xref: RHEA:33027 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0043824 +name: succinylglutamate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH." [EC:1.2.1.71, RHEA:10812] +synonym: "AruD" RELATED [] +synonym: "AstD" RELATED [] +synonym: "N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.71] +synonym: "N-succinylglutamate 5-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.71] +synonym: "SGSD" RELATED [] +synonym: "succinyl glutamate-semialdehyde dehydrogenase activity" EXACT [] +synonym: "succinylglutamic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.71] +xref: EC:1.2.1.71 +xref: KEGG_REACTION:R05049 +xref: MetaCyc:SUCCGLUALDDEHYD-RXN +xref: RHEA:10812 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043825 +name: succinylornithine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16953] +synonym: "2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" RELATED [EC:2.6.1.81] +synonym: "AstC" RELATED [] +synonym: "N(2)-succinylornithine 5-aminotransferase activity" RELATED [EC:2.6.1.81] +synonym: "N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [] +synonym: "N2-succinylornithine 5-aminotransferase activity" EXACT [] +synonym: "SOAT" RELATED [] +synonym: "succinyl ornithine transaminase activity" EXACT [] +synonym: "succinyl-ornithine transaminase activity" RELATED [EC:2.6.1.81] +synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.81] +xref: EC:2.6.1.81 +xref: KEGG_REACTION:R04217 +xref: MetaCyc:SUCCORNTRANSAM-RXN +xref: RHEA:16953 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043826 +name: sulfur oxygenase reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." [PMID:1522063] +synonym: "SOR" RELATED [] +synonym: "sulphur oxygenase reductase activity" EXACT [] +xref: MetaCyc:RXN-8226 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043827 +name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [PMID:14739239] +synonym: "TrmI" RELATED [] +synonym: "tRNA (adenine-57, 58 N1-) methyltransferase activity" EXACT [] +synonym: "tRNA (adenine-57, 58-N1-) methyltransferase activity" EXACT [] +synonym: "tRNA (m1A) MTase" BROAD [] +is_a: GO:0016429 ! tRNA (adenine-N1-)-methyltransferase activity + +[Term] +id: GO:0043828 +name: tRNA 2-selenouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [PMID:14594807, RHEA:42716] +xref: EC:2.9.1.3 +xref: MetaCyc:RXN0-2281 +xref: RHEA:42716 +is_a: GO:0016785 ! selenotransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043829 +name: tRNA-specific adenosine-37 deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [PMID:8915538, PMID:9707437] +synonym: "TAD1" RELATED [] +synonym: "tRNA(Ala)-A37 deaminase activity" EXACT [] +synonym: "tRNA-specific adenosine deaminase 1" EXACT [] +is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity + +[Term] +id: GO:0043830 +name: thiol-driven fumarate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [PMID:2509466] +xref: EC:1.3.99.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0043831 +name: thiosulfate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [EC:1.8.5.2, RHEA:10936] +synonym: "DoxA" RELATED [] +synonym: "DoxD" RELATED [] +synonym: "thiosulfate oxidoreductase, tetrathionate-forming activity" RELATED [EC:1.8.5.2] +synonym: "thiosulfate:6-decylubiquinone oxidoreductase activity" RELATED [EC:1.8.5.2] +synonym: "thiosulfate:quinone oxidoreductase activity" RELATED [EC:1.8.5.2] +synonym: "thiosulphate dehydrogenase (quinone) activity" EXACT [] +synonym: "thiosulphate:quinone oxidoreductase activity" EXACT [] +synonym: "TQO" RELATED [] +xref: EC:1.8.5.2 +xref: KEGG_REACTION:R07177 +xref: MetaCyc:1.8.5.2-RXN +xref: RHEA:10936 +is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0043833 +name: [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [methyl-Co(III) methylamine-specific corrinoid protein] + coenzyme M = [Co(I) methylamine-specific corrinoid protein] + H+ + methyl-coenzyme M. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [RHEA:18773] +comment: This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. +synonym: "methylamine-specific methylcobalamin:coenzyme M methyltransferase activity" EXACT [] +synonym: "methylamine-specific methylcobalamin:CoM methyltransferase activity" EXACT [] +synonym: "methylcobamide:coenzyme M methyltransferase activity" BROAD [] +synonym: "methylcobamide:CoM methyltransferase activity" BROAD [] +synonym: "monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +synonym: "MT2-A" BROAD [EC:2.1.1.247] +xref: EC:2.1.1.247 +xref: MetaCyc:RXN-8099 +xref: MetaCyc:RXN-8101 +xref: MetaCyc:RXN-8103 +xref: RHEA:18773 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043834 +name: trimethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [PMID:9006042] +comment: This function is the first step in the pathway of methanogenesis from trimethylamine. +synonym: "MT1" BROAD [] +synonym: "mttB1" RELATED [] +synonym: "TMA methyltransferase 1" EXACT [] +synonym: "trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity" NARROW [] +synonym: "trimethylamine:corrinoid methyltransferase activity" EXACT [] +xref: EC:2.1.1.250 +xref: MetaCyc:RXN-8102 +xref: RHEA:39287 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043835 +name: obsolete uracil/thymine dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [GOC:curators] +comment: This term was made obsolete because it represents two separate molecular functions. +synonym: "uracil oxidase activity" RELATED [EC:1.17.99.4] +synonym: "uracil-thymine oxidase activity" RELATED [EC:1.17.99.4] +synonym: "uracil/thymine dehydrogenase activity" EXACT [] +synonym: "uracil:acceptor oxidoreductase activity" NARROW [] +xref: EC:1.17.99.4 +is_obsolete: true +consider: GO:0050383 +consider: GO:0052620 + +[Term] +id: GO:0043836 +name: xanthine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [MetaCyc:R127-RXN, PMID:13278326] +synonym: "xanthinase activity" EXACT [] +xref: MetaCyc:R127-RXN +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0043837 +name: valine dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [PMID:10612726, PMID:2803248] +synonym: "ValDH" RELATED [] +xref: EC:1.4.1.23 +xref: RHEA:30763 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043838 +name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [PMID:15795227] +comment: Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. +synonym: "EptB" RELATED [] +synonym: "phosphoethanolamine transferase" BROAD [] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0043839 +name: lipid A phosphate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [PMID:15994324] +synonym: "lipid A 1-phosphomethyltransferase activity" EXACT [] +synonym: "lipid A methyltransferase" BROAD [] +synonym: "lipid A phosphomethyltransferase activity" EXACT [] +synonym: "LmtA" RELATED [] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0043840 +name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [PMID:12670965] +synonym: "BCAT" RELATED [] +synonym: "branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] +synonym: "branched-chain amino acid aminotransferase" BROAD [] +synonym: "branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity" EXACT [] +xref: MetaCyc:RXN-7708 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043841 +name: (S)-lactate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [PMID:11535063] +synonym: "lactate 2-kinase activity" EXACT [] +xref: MetaCyc:RXN-8076 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043842 +name: Kdo transferase activity +namespace: molecular_function +def: "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [PMID:1577828, PMID:2033061, PMID:9195966] +synonym: "3-deoxy-D-manno-octulosonic-acid transferase activity" EXACT [] +synonym: "kdtA" RELATED [] +synonym: "WaaA" RELATED [] +xref: EC:2.4.99.12 +xref: EC:2.4.99.13 +xref: EC:2.4.99.14 +xref: EC:2.4.99.15 +xref: MetaCyc:KDOTRANS-RXN +xref: MetaCyc:KDOTRANS2-RXN +is_a: GO:0016757 ! glycosyltransferase activity + +[Term] +id: GO:0043843 +name: ADP-specific glucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147] +synonym: "ADP-dependent glucokinase activity" RELATED [EC:2.7.1.147] +synonym: "ADP:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.147] +xref: EC:2.7.1.147 +xref: Reactome:R-HSA-5696021 "ADPGK:Mg2+ phosphorylates Glc to G6P" +xref: RHEA:11460 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043844 +name: ADP-specific phosphofructokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146] +synonym: "ADP-6-phosphofructokinase activity" RELATED [EC:2.7.1.146] +synonym: "ADP-dependent phosphofructokinase activity" RELATED [EC:2.7.1.146] +synonym: "ADP-Pfk activity" RELATED [EC:2.7.1.146] +synonym: "ADP:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.146] +xref: EC:2.7.1.146 +xref: RHEA:20105 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043845 +name: DNA polymerase III, proofreading complex +namespace: cellular_component +def: "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [PMID:16973612, Wikipedia:Pol_III] +synonym: "DNA polymerase III, proof-reading complex" EXACT [] +synonym: "DNA polymerase III, proof-reading subcomplex" EXACT [] +synonym: "DNA polymerase III, proofreading subcomplex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0044776 ! DNA polymerase III, core complex + +[Term] +id: GO:0043846 +name: DNA polymerase III, clamp loader complex +namespace: cellular_component +def: "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977] +synonym: "clamp loader complex" BROAD [] +synonym: "DNA polymerase III, DnaX complex" EXACT [] +synonym: "DNA polymerase III, DnaX subcomplex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0009360 ! DNA polymerase III complex + +[Term] +id: GO:0043847 +name: DNA polymerase III, clamp loader chi/psi subcomplex +namespace: cellular_component +def: "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [PMID:12940977] +synonym: "DNA polymerase III, DnaX complex, chi/psi subcomplex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043846 ! DNA polymerase III, clamp loader complex + +[Term] +id: GO:0043848 +name: obsolete excinuclease cho activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [PMID:11818552] +comment: This term was obsoleted because it represented a gene product. +synonym: "cho" RELATED [] +synonym: "endonuclease cho" EXACT [] +synonym: "uvrc homolog protein" RELATED [] +is_obsolete: true + +[Term] +id: GO:0043849 +name: Ras palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [PMID:16000296] +synonym: "DHHC cysteine-rich domain-containing protein ERF2" RELATED [] +synonym: "ERF2" RELATED [] +synonym: "palmitoyltransferase ERF2" RELATED [] +synonym: "Ras protein acyltransferase activity" EXACT [] +is_a: GO:0019706 ! protein-cysteine S-palmitoyltransferase activity + +[Term] +id: GO:0043850 +name: RecFOR complex +namespace: cellular_component +def: "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [PMID:12769856] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0043852 +name: monomethylamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [PMID:9195968] +comment: This function is the first step in the pathway of methanogenesis from monomethylamine. +synonym: "MMAMT" RELATED [] +synonym: "monomethylamine:corrinoid methyltransferase activity" EXACT [] +synonym: "MtmB" RELATED [] +xref: EC:2.1.1.248 +xref: MetaCyc:RXN-8098 +xref: RHEA:26059 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0043853 +name: methanol-CoM methyltransferase complex +namespace: cellular_component +def: "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [PMID:9363780] +synonym: "methanol-coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol: coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol: CoM methyltransferase complex" EXACT [] +synonym: "methanol:coenzyme M methyltransferase complex" EXACT [] +synonym: "methanol:CoM methyltransferase complex" EXACT [] +xref: MetaCyc:CPLX-421 +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0043854 +name: cyclic nucleotide-gated mechanosensitive ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, PMID:22206667] +synonym: "cyclic nucleotide gated mechanosensitive ion channel activity" EXACT [] +synonym: "cyclic nucleotide regulated mechanosensitive ion channel" EXACT [] +synonym: "cyclic nucleotide-regulated mechanosensitive ion channel" EXACT [] +synonym: "cyclic nucleotide-regulated small mechanosensitive ion channel" RELATED [] +synonym: "MscS" RELATED [] +synonym: "small conductance mechanosensitive ion channel" EXACT [] +is_a: GO:0008381 ! mechanosensitive ion channel activity + +[Term] +id: GO:0043855 +name: cyclic nucleotide-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl] +synonym: "cyclic nucleotide activated ion channel activity" EXACT [] +synonym: "cyclic nucleotide gated ion channel activity" EXACT [] +synonym: "cyclic nucleotide-activated ion channel activity" EXACT [] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0043856 +name: anti-sigma factor antagonist activity +namespace: molecular_function +def: "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799] +synonym: "anti-anti-sigma factor activity" EXACT [] +is_a: GO:0140110 ! transcription regulator activity + +[Term] +id: GO:0043857 +name: N-acetylornithine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate." [EC:2.1.3.9, RHEA:18609] +synonym: "acetylornithine transcarbamylase activity" EXACT [] +synonym: "AOTC" RELATED [] +synonym: "carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.9] +synonym: "carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity" RELATED [EC:2.1.3.9] +synonym: "N-acetylornithine transcarbamylase activity" EXACT [] +xref: EC:2.1.3.9 +xref: KEGG_REACTION:R07245 +xref: MetaCyc:2.1.3.9-RXN +xref: RHEA:18609 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0043858 +name: arginine:ornithine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979] +synonym: "ArcD" RELATED [] +synonym: "arginine-ornithine antiporter activity" EXACT [] +synonym: "arginine/ornithine antiporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0043859 +name: obsolete cyanophycinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200] +comment: This term was made obsolete because it represents a gene product. +synonym: "cyanophycinase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008236 + +[Term] +id: GO:0043860 +name: cyanophycin synthetase activity +namespace: molecular_function +def: "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl] +synonym: "cphA" RELATED [] +xref: EC:6.3.1.- +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0043861 +name: agmatine:putrescine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272] +synonym: "agmatine-putrescine antiporter activity" EXACT [] +synonym: "agmatine/putrescine antiporter activity" EXACT [] +is_a: GO:0015489 ! putrescine transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0043862 +name: arginine:agmatine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215] +synonym: "AdiC" RELATED [] +synonym: "arginine-agmatine antiporter activity" EXACT [] +synonym: "arginine-agmatine exchange transporter activity" EXACT [] +synonym: "arginine/agmatine antiporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0043863 +name: 4-hydroxy-2-ketopimelate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN] +synonym: "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity" EXACT [] +synonym: "HHED aldolase activity" EXACT [] +synonym: "HpaI" RELATED [] +synonym: "HpcH" RELATED [] +xref: MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN +xref: RHEA:25788 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043864 +name: indoleacetamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, RHEA:34371] +synonym: "IaaH" RELATED [] +synonym: "IAH" EXACT [] +synonym: "indole acetamide hydrolase activity" EXACT [] +synonym: "indole-3-acetamide hydrolase activity" EXACT [] +synonym: "Tms2" RELATED [] +xref: EC:3.5.1.4 +xref: MetaCyc:G-5841 +xref: RHEA:34371 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043865 +name: methionine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1990240 +def: "Enables the transfer of methionine from one side of a membrane to the other." [GOC:jl] +synonym: "methionine importer" RELATED [] +synonym: "methionine importer activity" NARROW [] +synonym: "methionine importing activity" NARROW [] +synonym: "methionine-importing activity" NARROW [] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0043866 +name: adenylyl-sulfate reductase (thioredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10] +synonym: "AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [] +synonym: "AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)" RELATED [EC:1.8.4.10] +synonym: "thioredoxin-dependent 5'-adenylylsulfate reductase activity" EXACT [] +xref: EC:1.8.4.10 +xref: RHEA:21976 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0043867 +name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953] +synonym: "archaeal tRNA-guanine transglycosylase activity" EXACT [] +synonym: "archaeosine tRNA-ribosyltransferase activity" EXACT [] +synonym: "TgtA" RELATED [] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0043870 +name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183] +comment: This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. +synonym: "AGPR" RELATED [] +synonym: "ArgC" RELATED [] +synonym: "LysY" RELATED [] +synonym: "N-acetyl-alpha-glutamyl-phosphate reductase activity" EXACT [] +synonym: "N-acetyl-aminoadipate semialdehyde dehydrogenase activity" EXACT [] +synonym: "NAGSA dehydrogenase activity" BROAD [] +xref: MetaCyc:RXN-5183 +xref: RHEA:41948 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043871 +name: delta1-piperideine-6-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033] +comment: This function is part of the pipecolate pathway of lysine catabolism. +synonym: "AmaB" RELATED [] +synonym: "PIPOX" RELATED [] +xref: MetaCyc:RXN-8162 +xref: RHEA:49476 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043872 +name: lysine:cadaverine antiporter activity +namespace: molecular_function +alt_id: GO:0015490 +alt_id: GO:0015497 +def: "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2] +synonym: "cadaverine transmembrane transporter activity" NARROW [] +synonym: "cadaverine:lysine antiporter activity" EXACT [] +synonym: "lysine-cadaverine antiporter activity" EXACT [] +synonym: "lysine/cadaverine antiporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0043873 +name: pyruvate-flavodoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705] +synonym: "NifJ" RELATED [] +synonym: "pyruvate:flavodoxin oxidoreductase activity" EXACT [] +xref: MetaCyc:PYFLAVOXRE-RXN +xref: RHEA:44140 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043874 +name: acireductone synthase activity +namespace: molecular_function +def: "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77, RHEA:21700] +comment: This function is involved in the process of methionine salvage. +synonym: "5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)" RELATED [EC:3.1.3.77] +synonym: "E-1" RELATED [] +synonym: "E-1 enolase-phosphatase" BROAD [] +xref: EC:3.1.3.77 +xref: MetaCyc:3.1.3.77-RXN +xref: Reactome:R-HSA-1237129 "Acireductone is created" +xref: RHEA:21700 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0043875 +name: 2-ketobutyrate formate-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901] +comment: This function is part of an anaerobic pathway for the catabolism of L-threonine. +synonym: "keto-acid formate acetyltransferase" BROAD [] +synonym: "KFL" EXACT [] +synonym: "TdcE" RELATED [] +xref: MetaCyc:KETOBUTFORMLY-RXN +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043876 +name: D-threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221] +synonym: "D-allo-TA" EXACT [] +synonym: "D-allo-threonine aldolase activity" EXACT [] +synonym: "D-TA" EXACT [] +synonym: "DtaAS" RELATED [] +synonym: "low-specificity D-threonine aldolase" NARROW [] +xref: EC:4.1.2.42 +xref: MetaCyc:4.1.2.42-RXN +xref: RHEA:15257 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0043877 +name: galactosamine-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310] +comment: This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. +synonym: "AgaI" RELATED [] +synonym: "galactosamine-6-phosphate deaminase activity" EXACT [] +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0043878 +name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity" EXACT [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD) activity" EXACT [] +synonym: "NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] +synonym: "non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD)" EXACT [] +xref: EC:1.2.1.3 +xref: MetaCyc:RXN-3443 +xref: RHEA:25294 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043879 +name: glycolate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [GOC:jl, RHEA:29447] +synonym: "glcA" RELATED [] +synonym: "glycolate permease" RELATED [] +synonym: "glycolic acid transmembrane transporter activity" EXACT [] +synonym: "hydroxyacetic acid transmembrane transporter activity" EXACT [] +xref: RHEA:29447 +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0043880 +name: crotonyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reduction of crotonyl-CoA to butyryl-CoA." [InterPro:IPR010085, PMID:11162231] +synonym: "CCR" EXACT [] +synonym: "crotonyl-coenzyme A reductase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043881 +name: mesaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937] +comment: This function is part of an alternate glyoxylate cycle for acetate assimilation. +synonym: "beta-methylmalyl-CoA dehydratase activity" EXACT [] +synonym: "mch" RELATED [] +synonym: "mesaconyl-coenzyme A hydratase activity" EXACT [] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043882 +name: malate:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309] +synonym: "malate Na(+) symporter activity" EXACT [] +synonym: "malate-sodium symporter activity" EXACT [] +synonym: "malate/sodium cotransporter activity" BROAD [] +synonym: "malate/sodium symporter activity" EXACT [] +synonym: "malate:Na+ symporter activity" EXACT [] +synonym: "malate:sodium cotransporter activity" BROAD [] +synonym: "Na(+)-malate symporter activity" EXACT [] +synonym: "Na+:malate symporter activity" EXACT [] +synonym: "sodium-dependent malate transporter" BROAD [] +synonym: "sodium/malate symporter activity" EXACT [] +synonym: "sodium:malate symporter activity" EXACT [] +is_a: GO:0015140 ! malate transmembrane transporter activity +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity + +[Term] +id: GO:0043883 +name: malolactic enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: malate + H+ = L-lactate + CO2." [MetaCyc:RXN8E-5623, PMID:3139053] +comment: This function is part of the process of degradation of L-malic acid by lactic acid bacteria. +synonym: "MleS" RELATED [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043884 +name: CO-methylating acetyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656] +synonym: "acetyl-CoA synthase activity" BROAD [] +synonym: "acetyl-CoA:corrinoid protein O-acetyltransferase activity" EXACT [] +synonym: "ACS" RELATED [EC:2.3.1.169] +synonym: "CO-methylating acetyl-coenzyme A synthase activity" EXACT [] +xref: EC:2.3.1.169 +xref: MetaCyc:ACETYLSYNCLTH-RXN +xref: RHEA:45212 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0043885 +name: carbon-monoxide dehydrogenase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4] +synonym: "carbon monoxide dehydrogenase (ferredoxin) activity" EXACT [] +synonym: "carbon monoxide dehydrogenase activity" BROAD [] +synonym: "carbon-monoxide dehydrogenase activity" BROAD [EC:1.2.7.4] +synonym: "carbon-monoxide,water:ferredoxin oxidoreductase activity" EXACT [] +synonym: "carbon-monoxide:(acceptor) oxidoreductase activity" EXACT [] +synonym: "CO dehydrogenase activity" EXACT [] +synonym: "CO-dehydrogenase (ferredoxin) activity" EXACT [] +synonym: "CO-dehydrogenase activity" EXACT [] +synonym: "CODH" RELATED [] +xref: EC:1.2.7.4 +xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0043886 +name: structural constituent of carboxysome +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO(2)." [GOC:jl, PMID:28934381] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0043887 +name: melibiose:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646] +synonym: "MelB" RELATED [] +synonym: "melibiose carrier protein" RELATED [] +synonym: "melibiose permease" BROAD [] +synonym: "melibiose-Na+ symporter activity" EXACT [] +synonym: "melibiose-sodium symporter activity" EXACT [] +synonym: "melibiose/Na+ symporter activity" EXACT [] +synonym: "melibiose/sodium symporter activity" EXACT [] +synonym: "melibiose:Na+ symporter activity" EXACT [] +synonym: "Na+ (Li+)/melibiose symporter activity" EXACT [] +synonym: "Na+-melibiose symporter activity" EXACT [] +synonym: "Na+/melibiose symporter activity" EXACT [] +synonym: "Na+:melibiose symporter activity" EXACT [] +synonym: "sodium-melibiose symporter activity" EXACT [] +synonym: "sodium/melibiose symporter activity" EXACT [] +synonym: "sodium:melibiose symporter activity" EXACT [] +synonym: "thiomethylgalactoside permease II" RELATED [] +is_a: GO:0015370 ! solute:sodium symporter activity +is_a: GO:0015487 ! melibiose:cation symporter activity + +[Term] +id: GO:0043888 +name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480] +comment: This function is involved in archaeal lipid synthesis. +synonym: "2,3-dGGGPS" EXACT [] +synonym: "DGGGP synthase activity" EXACT [] +synonym: "DGGGPS" EXACT [] +synonym: "UbiA" RELATED [] +xref: EC:2.5.1.- +is_a: GO:0002094 ! polyprenyltransferase activity +is_a: GO:0004337 ! geranyltranstransferase activity + +[Term] +id: GO:0043889 +name: (S)-3-O-geranylgeranylglyceryl phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023] +comment: This function is involved in archaeal lipid synthesis. +synonym: "(S)-3-O-geranylgeranylglycerylphosphate synthase activity" EXACT [] +synonym: "(S)-GGGP synthase activity" EXACT [] +synonym: "GGGP synthase activity" EXACT [] +synonym: "GGGPS" EXACT [] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0043890 +name: N-acetylgalactosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4] +synonym: "acetylgalactosamine 6-sulfatase activity" EXACT [] +synonym: "chondroitin sulfatase" BROAD [] +synonym: "chondroitinase" BROAD [] +synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.4] +synonym: "galactose-6-sulfate sulfatase activity" EXACT [] +synonym: "N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity" EXACT [] +synonym: "N-acetylgalactosamine 6-sulfatase activity" EXACT [] +synonym: "N-acetylgalactosamine-6-sulfate sulfatase activity" EXACT [] +xref: EC:3.1.6.4 +xref: MetaCyc:3.1.6.4-RXN +xref: Reactome:R-HSA-1630304 "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate" +xref: Reactome:R-HSA-2263490 "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate" +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0043891 +name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59] +synonym: "D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)" EXACT [] +synonym: "glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" EXACT [] +synonym: "NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.59] +synonym: "triosephosphate dehydrogenase (NAD(P))" EXACT [] +synonym: "triosephosphate dehydrogenase (NAD(P)+)" RELATED [EC:1.2.1.59] +xref: EC:1.2.1.59 +xref: MetaCyc:GAPDHSYNEC-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043892 +name: methylglyoxal reductase (NADPH-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+." [EC:1.1.1.283] +synonym: "Gre2" RELATED [] +synonym: "lactaldehyde dehydrogenase (NADP+)" EXACT [] +synonym: "lactaldehyde:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.283] +xref: EC:1.1.1.283 +xref: MetaCyc:1.1.1.283-RXN +xref: MetaCyc:RXN-8636 +xref: RHEA:21748 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043893 +name: acetate:cation symporter activity +namespace: molecular_function +def: "Enables the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl, PMID:14563880] +synonym: "acetate permease" BROAD [] +synonym: "acetate-cation symporter activity" EXACT [] +synonym: "acetate/cation symporter activity" EXACT [] +synonym: "ActP" RELATED [] +synonym: "cation-acetate symporter activity" EXACT [] +synonym: "cation/acetate symporter activity" EXACT [] +synonym: "cation:acetate symporter activity" EXACT [] +is_a: GO:0015123 ! acetate transmembrane transporter activity +is_a: GO:0015294 ! solute:cation symporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0043894 +name: acetyl-CoA synthetase acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963] +synonym: "Pat" RELATED [] +synonym: "Pat enzyme" EXACT [] +synonym: "protein acetyltransferase activity" BROAD [] +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0043895 +name: cyclomaltodextrin glucanotransferase activity +namespace: molecular_function +def: "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19] +synonym: "1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)" EXACT [] +synonym: "alpha-1,4-glucan 4-glycosyltransferase, cyclizing" RELATED [] +synonym: "alpha-cyclodextrin glucanotransferase" RELATED [] +synonym: "alpha-cyclodextrin glycosyltransferase" RELATED [] +synonym: "Bacillus macerans amylase" RELATED [] +synonym: "beta-cyclodextrin glucanotransferase" RELATED [] +synonym: "beta-cyclodextrin glycosyltransferase" RELATED [] +synonym: "BMA" RELATED [] +synonym: "CGTase" RELATED [] +synonym: "cyclodextrin glucanotransferase" BROAD [] +synonym: "cyclodextrin glycosyltransferase" RELATED [] +synonym: "cyclomaltodextrin glucotransferase" RELATED [] +synonym: "cyclomaltodextrin glycosyltransferase" RELATED [] +synonym: "gamma-cyclodextrin glycosyltransferase" RELATED [] +synonym: "konchizaimu" RELATED [] +synonym: "neutral-cyclodextrin glycosyltransferase" RELATED [] +xref: EC:2.4.1.19 +xref: MetaCyc:2.4.1.19-RXN +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0043896 +name: glucan 1,6-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70] +synonym: "exo-1,6-alpha-glucosidase activity" RELATED [EC:3.2.1.70] +synonym: "exo-1,6-beta-glucosidase" RELATED [] +synonym: "glucan alpha-1,6-D-glucohydrolase activity" RELATED [EC:3.2.1.70] +synonym: "glucan-1,6-alpha-glucosidase activity" EXACT [] +synonym: "glucodextranase activity" RELATED [EC:3.2.1.70] +synonym: "glucodextrinase" BROAD [] +xref: EC:3.2.1.70 +xref: MetaCyc:3.2.1.70-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0043897 +name: glucan 1,4-alpha-maltohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133] +synonym: "1,4-alpha-D-glucan alpha-maltohydrolase activity" EXACT [] +synonym: "glucan-1,4-alpha-maltohydrolase activity" EXACT [] +synonym: "maltogenic alpha-amylase activity" EXACT [] +xref: EC:3.2.1.133 +xref: MetaCyc:3.2.1.133-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0043898 +name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866] +synonym: "2,3-dihydroxybiphenyl-1,2-dioxygenase activity" EXACT [] +synonym: "BphC" RELATED [] +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0043899 +name: phosphoserine:homoserine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121] +synonym: "thrH" RELATED [] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0043900 +name: obsolete regulation of multi-organism process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] +comment: This term was obsoleted because it is an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0043901 +name: obsolete negative regulation of multi-organism process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] +comment: This term was obsoleted because it is an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0043902 +name: obsolete positive regulation of multi-organism process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] +comment: This term was obsoleted because it is an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0043903 +name: regulation of biological process involved in symbiotic interaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl] +comment: regulation of interspecies interactions between organisms +synonym: "regulation of interspecies interactions between organisms" BROAD [] +synonym: "regulation of symbiosis, encompassing mutualism through parasitism" RELATED [] +synonym: "regulation of symbiotic process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0043904 +name: isochorismate pyruvate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: isochorismate = salicylate + pyruvate." [GOC:jl, PMID:16248620] +synonym: "IPL" EXACT [] +synonym: "isochorismate-pyruvate lyase activity" EXACT [] +xref: EC:4.2.99.21 +xref: MetaCyc:RXN-1981 +xref: RHEA:27874 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0043905 +name: Ser-tRNA(Thr) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr)." [GOC:jl, PMID:15240874] +synonym: "Ser-tRNAThr hydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0052689 ! carboxylic ester hydrolase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043906 +name: Ala-tRNA(Pro) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro)." [GOC:jl, PMID:14663147] +synonym: "Ala-tRNAPro hydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0043907 +name: Cys-tRNA(Pro) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro)." [GOC:jl, PMID:15886196] +synonym: "Cys-tRNA(Pro) deacetylase activity" EXACT [] +synonym: "Cys-tRNAPro hydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0043908 +name: Ser(Gly)-tRNA(Ala) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147] +synonym: "Ser(Gly)-tRNAAla hydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0052689 ! carboxylic ester hydrolase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043909 +name: N-acetylcitrulline deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, PMID:16750290, RHEA:61092] +synonym: "acetylcitrulline deacetylase activity" EXACT [] +synonym: "N-acetyl-L-citrulline deacetylase activity" EXACT [] +xref: RHEA:61092 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0043910 +name: ATP:coenzyme F420 adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate." [GOC:jl, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473] +synonym: "ATP:coenzyme F420 adenyltransferase activity" EXACT [] +synonym: "coenzyme F390-A synthetase activity" EXACT [] +xref: MetaCyc:RXN-9385 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0043911 +name: D-lysine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, PMID:17259313] +synonym: "D-lysine aminotransferase activity" EXACT [] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0043912 +name: D-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide." [GOC:jl, PMID:17259313] +xref: EC:1.4.3.- +is_a: GO:0003884 ! D-amino-acid oxidase activity + +[Term] +id: GO:0043913 +name: obsolete chromosome segregation-directing complex +namespace: cellular_component +def: "OBSOLETE. A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918] +comment: This term was obsoleted because the three proteins mentioned in the definition are not part of the same complex. +synonym: "chromosome segregation directing complex" EXACT [] +synonym: "longitudinal peptidoglycan synthesis-directing complex" EXACT [] +synonym: "MreBCD complex" NARROW [] +is_obsolete: true + +[Term] +id: GO:0043914 +name: NADPH:sulfur oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625] +synonym: "CoA-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H elemental sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H sulfur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H sulphur oxidoreductase activity" EXACT [] +synonym: "NAD(P)H:sulfur oxidoreductase activity" EXACT [] +synonym: "NADPH:sulphur oxidoreductase activity" EXACT [] +synonym: "NSR" EXACT [] +xref: EC:1.8.1.18 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0043915 +name: L-seryl-tRNA(Sec) kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, PMID:16201757, RHEA:25037] +synonym: "O-phosphoseryl-tRNA(Sec) kinase activity" EXACT [] +xref: EC:2.7.1.164 +xref: MetaCyc:RXN-10038 +xref: RHEA:25037 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0043916 +name: DNA-7-methylguanine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998] +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0043917 +name: ribose 1,5-bisphosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl] +synonym: "ribose-1,5-bisphosphate isomerase activity" EXACT [] +xref: EC:5.3.1.29 +xref: MetaCyc:RXN-8801 +xref: RHEA:32243 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0043918 +name: cadaverine aminopropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, PMID:17545282] +synonym: "cadaverine aminopropyl transferase activity" EXACT [] +xref: EC:2.5.1.104 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043919 +name: agmatine aminopropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, PMID:15983049] +synonym: "agmatine aminopropyl transferase activity" EXACT [] +xref: EC:2.5.1.104 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0043920 +name: aminopropylagmatine ureohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, PMID:15983049, RHEA:35827] +xref: EC:3.5.3.24 +xref: RHEA:35827 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0043921 +name: modulation by host of viral transcription +namespace: biological_process +def: "Any process in which a host organism modulates the frequency, rate or extent of viral transcription." [GOC:jl] +synonym: "regulation by host of viral transcription" EXACT [] +synonym: "regulation of viral transcription by host" EXACT [] +is_a: GO:0043922 ! negative regulation by host of viral transcription +is_a: GO:0044793 ! negative regulation by host of viral process + +[Term] +id: GO:0043922 +name: negative regulation by host of viral transcription +namespace: biological_process +def: "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl] +synonym: "negative regulation of viral transcription by host" EXACT [] +is_a: GO:0051851 ! modulation by host of symbiont process +relationship: negatively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0043923 +name: positive regulation by host of viral transcription +namespace: biological_process +def: "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl] +synonym: "positive regulation of viral transcription by host" EXACT [] +is_a: GO:0051851 ! modulation by host of symbiont process +relationship: positively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0043924 +name: suramin binding +namespace: molecular_function +def: "Binding to suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [GOC:jl, Wikipedia:Suramin] +synonym: "Germanin binding" EXACT [] +is_a: GO:0033218 ! amide binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0043927 +name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic +relationship: part_of GO:0000294 ! nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay + +[Term] +id: GO:0043928 +name: exonucleolytic catabolism of deadenylated mRNA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic +relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:0043929 +name: primary ovarian follicle growth involved in double layer follicle stage +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo] +synonym: "primary ovarian follicle growth during double layer follicle stage" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001545 ! primary ovarian follicle growth +relationship: part_of GO:0048161 ! double layer follicle stage + +[Term] +id: GO:0043930 +name: primary ovarian follicle growth involved in primary follicle stage +namespace: biological_process +def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo] +synonym: "primary ovarian follicle growth during primary follicle stage" RELATED [GOC:dph, GOC:tb] +is_a: GO:0001545 ! primary ovarian follicle growth +relationship: part_of GO:0048160 ! primary follicle stage + +[Term] +id: GO:0043931 +name: ossification involved in bone maturation +namespace: biological_process +def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo] +synonym: "ossification involved in bone modeling" NARROW [GO_REF:0000034] +synonym: "ossification involved in skeletal development" EXACT [GOC:dph] +is_a: GO:0001503 ! ossification +relationship: part_of GO:0070977 ! bone maturation + +[Term] +id: GO:0043932 +name: ossification involved in bone remodeling +namespace: biological_process +def: "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo] +synonym: "ossification involved in bone remodelling" RELATED [] +is_a: GO:0001503 ! ossification +relationship: part_of GO:0046849 ! bone remodeling + +[Term] +id: GO:0043933 +name: protein-containing complex organization +namespace: biological_process +alt_id: GO:0034600 +alt_id: GO:0034621 +alt_id: GO:0071822 +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] +synonym: "cellular macromolecular complex organization" RELATED [] +synonym: "cellular macromolecular complex subunit organisation" RELATED [] +synonym: "cellular macromolecular complex subunit organization" RELATED [] +synonym: "macromolecular complex organization" RELATED [] +synonym: "macromolecular complex subunit organisation" RELATED [] +synonym: "macromolecular complex subunit organization" RELATED [] +synonym: "protein complex subunit organisation" EXACT [GOC:mah] +synonym: "protein complex subunit organization" EXACT [] +synonym: "protein-containing complex subunit organization" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043934 +name: sporulation +namespace: biological_process +def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] +subset: goslim_metagenomics +subset: goslim_yeast +xref: Wikipedia:Spore +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0043935 +name: sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] +is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore +is_a: GO:0034293 ! sexual sporulation +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0043936 +name: asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] +synonym: "asexual reproduction resulting in the formation of a cellular spore" EXACT [GOC:di] +synonym: "asexual sporulation resulting in the formation of a viable spore" BROAD [GOC:di] +is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore +is_a: GO:0030436 ! asexual sporulation + +[Term] +id: GO:0043937 +name: regulation of sporulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043938 +name: positive regulation of sporulation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043939 +name: negative regulation of sporulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators] +is_a: GO:0043937 ! regulation of sporulation +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0043934 ! sporulation + +[Term] +id: GO:0043940 +name: regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0034306 ! regulation of sexual sporulation +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +relationship: regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043941 +name: positive regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043942 +name: negative regulation of sexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +relationship: negatively_regulates GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043943 +name: regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] +is_a: GO:0034305 ! regulation of asexual sporulation +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +relationship: regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043944 +name: negative regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] +is_a: GO:0042174 ! negative regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:1903665 ! negative regulation of asexual reproduction +relationship: negatively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043945 +name: positive regulation of asexual sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0045881 ! positive regulation of sporulation resulting in formation of a cellular spore +is_a: GO:1903666 ! positive regulation of asexual reproduction +relationship: positively_regulates GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0043946 +name: obsolete positive regulation of catalytic activity in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of enzyme activity in other organism" NARROW [] +synonym: "activation of enzyme activity in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation of catalytic activity in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "up regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +synonym: "up-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +synonym: "upregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +is_obsolete: true +consider: GO:0140677 + +[Term] +id: GO:0043947 +name: obsolete positive regulation by host of symbiont catalytic activity +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation by host of symbiont enzyme activity" NARROW [] +synonym: "activation of symbiont enzyme activity" NARROW [] +synonym: "positive regulation by host of symbiont enzyme activity" EXACT [] +synonym: "up regulation by host of symbiont enzyme activity" EXACT [] +synonym: "up-regulation by host of symbiont enzyme activity" EXACT [] +synonym: "upregulation by host of symbiont enzyme activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043948 +name: obsolete induction by symbiont of host catalytic activity +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation by symbiont of host enzyme activity" NARROW [] +synonym: "activation of host enzyme activity" NARROW [] +synonym: "positive regulation by symbiont of host catalytic activity" EXACT [] +synonym: "positive regulation by symbiont of host enzyme activity" EXACT [] +synonym: "up regulation by symbiont of host enzyme activity" EXACT [] +synonym: "up-regulation by symbiont of host enzyme activity" EXACT [] +synonym: "upregulation by symbiont of host enzyme activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0043949 +name: regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043950 +name: positive regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "positive regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043951 +name: negative regulation of cAMP-mediated signaling +namespace: biological_process +def: "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl] +synonym: "negative regulation of cAMP-mediated signalling" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0019933 ! cAMP-mediated signaling + +[Term] +id: GO:0043952 +name: protein transport by the Sec complex +namespace: biological_process +def: "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'protein secretion by the type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. +synonym: "protein secretion by the Sec complex" NARROW [] +synonym: "protein translocation by the Sec complex" NARROW [] +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0043953 +name: protein transport by the Tat complex +namespace: biological_process +def: "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators] +comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. +synonym: "protein secretion by the TAT complex" NARROW [] +synonym: "protein translocation by the TAT complex" NARROW [] +synonym: "protein translocation by the twin-arginine translocation complex" NARROW [] +synonym: "twin-arginine translocation pathway" EXACT [] +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0043954 +name: cellular component maintenance +namespace: biological_process +alt_id: GO:0071956 +def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah] +synonym: "cellular component maintenance at cellular level" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0043955 +name: 3-hydroxypropionyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +synonym: "3-hydroxy propionyl-CoA synthetase activity" EXACT [] +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" NARROW [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:6.2.1.36 +xref: RHEA:26534 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0043956 +name: 3-hydroxypropionyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O." [GOC:jl, PMID:11821399] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +synonym: "3-hydroxy propionyl-CoA dehydratase activity" EXACT [] +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:4.2.1.116 +xref: MetaCyc:RXN-6383 +xref: RHEA:26518 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043957 +name: acryloyl-CoA reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399, RHEA:26454] +comment: Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. +synonym: "acetyl-coenzyme A synthetase" BROAD [] +synonym: "acetyl-coenzyme A synthetase/GroES-like domain" BROAD [] +synonym: "acryloyl-CoA reductase (NADPH) activity" EXACT [] +synonym: "acrylyl-CoA reductase (NADPH) activity" EXACT [] +synonym: "AMP-dependent synthetase and ligase" BROAD [] +synonym: "AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase" BROAD [] +synonym: "enoyl-CoA hydratase/isomerase" BROAD [] +xref: EC:1.3.1.84 +xref: KEGG_REACTION:R00919 +xref: MetaCyc:RXN-9087 +xref: RHEA:26454 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043958 +name: acryloyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323] +comment: Note that this function is part of the process of L-alanine fermentation to propionate. +synonym: "acryloyl-coenzyme A reductase activity" EXACT [] +synonym: "acrylyl-CoA reductase (NADH)" EXACT [] +synonym: "propionyl-CoA dehydrogenase" EXACT [] +xref: EC:1.3.99.3 +xref: MetaCyc:RXN-8568 +xref: RHEA:34471 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0043959 +name: L-erythro-3-methylmalyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl] +synonym: "HpcH/HpaI aldolase" RELATED [] +xref: EC:4.1.3.24 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0043960 +name: L-erythro-3-methylmalyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O." [GOC:jl] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0043961 +name: succinyl-CoA:(R)-citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, PMID:17259315] +synonym: "L-carnitine dehydratase/bile acid-inducible protein F" RELATED [] +synonym: "succinyl-CoA:(R)-citramalate CoA transferase activity" EXACT [] +synonym: "succinyl-CoA:R-citramalate CoA transferase" EXACT [] +xref: EC:2.8.3.20 +xref: MetaCyc:RXN-8966 +xref: RHEA:38279 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0043962 +name: obsolete negative regulation by host of symbiont adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0043963 +name: modulation by symbiont of host adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0043964 +name: induction by symbiont of host adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT [] +is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway + +[Term] +id: GO:0043965 +name: suppression by symbiont of host adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of host adenylate cyclase-mediated signal transduction" EXACT [] +is_a: GO:0043963 ! modulation by symbiont of host adenylate cyclase-mediated signal transduction +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway + +[Term] +id: GO:0043966 +name: histone H3 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] +is_a: GO:0016573 ! histone acetylation + +[Term] +id: GO:0043967 +name: histone H4 acetylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] +is_a: GO:0016573 ! histone acetylation + +[Term] +id: GO:0043968 +name: histone H2A acetylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an acetyl group." [GOC:jl] +is_a: GO:0016573 ! histone acetylation + +[Term] +id: GO:0043969 +name: histone H2B acetylation +namespace: biological_process +def: "The modification of histone H2B by the addition of an acetyl group." [GOC:jl] +is_a: GO:0016573 ! histone acetylation + +[Term] +id: GO:0043970 +name: histone H3-K9 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K9" EXACT [] +synonym: "histone H3K9 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation +is_a: GO:0061647 ! histone H3-K9 modification + +[Term] +id: GO:0043971 +name: histone H3-K18 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K18" EXACT [] +synonym: "histone H3K18 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043972 +name: histone H3-K23 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K23" EXACT [] +synonym: "histone H3K23 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043973 +name: histone H3-K4 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K4" EXACT [] +synonym: "histone H3K4 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043974 +name: histone H3-K27 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K27" EXACT [] +synonym: "histone H3K27 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043975 +name: histone H3-K36 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K36" EXACT [] +synonym: "histone H3K36 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043976 +name: histone H3-K79 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl] +synonym: "histone H3 acetylation at K79" EXACT [] +synonym: "histone H3K79 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0043977 +name: histone H2A-K5 acetylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] +synonym: "histone H2A acetylation at K5" EXACT [] +is_a: GO:0043968 ! histone H2A acetylation + +[Term] +id: GO:0043978 +name: histone H2A-K9 acetylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] +synonym: "histone H2A acetylation at K9" EXACT [] +is_a: GO:0043968 ! histone H2A acetylation + +[Term] +id: GO:0043979 +name: histone H2B-K5 acetylation +namespace: biological_process +def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] +synonym: "histone H2B acetylation at K5" EXACT [] +is_a: GO:0043969 ! histone H2B acetylation + +[Term] +id: GO:0043980 +name: histone H2B-K12 acetylation +namespace: biological_process +def: "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] +synonym: "histone H2B acetylation at K12" EXACT [] +is_a: GO:0043969 ! histone H2B acetylation + +[Term] +id: GO:0043981 +name: histone H4-K5 acetylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl] +synonym: "histone H4 acetylation at K5" EXACT [] +is_a: GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0043982 +name: histone H4-K8 acetylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl] +synonym: "histone H4 acetylation at K8" EXACT [] +is_a: GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0043983 +name: histone H4-K12 acetylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl] +synonym: "histone H4 acetylation at K12" EXACT [] +is_a: GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0043984 +name: histone H4-K16 acetylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl] +synonym: "histone H4 acetylation at K16" EXACT [] +is_a: GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0043985 +name: histone H4-R3 methylation +namespace: biological_process +def: "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah] +synonym: "histone H4 methylation at R3" EXACT [] +synonym: "histone H4 R3 methylation" EXACT [] +synonym: "histone H4R3me" EXACT [] +is_a: GO:0034969 ! histone arginine methylation + +[Term] +id: GO:0043987 +name: histone H3-S10 phosphorylation +namespace: biological_process +alt_id: GO:0043986 +def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl] +synonym: "histone H3 phosphorylation at S10" EXACT [] +synonym: "histone H3S10 phosphorylation" EXACT [] +is_a: GO:0035404 ! histone-serine phosphorylation + +[Term] +id: GO:0043988 +name: histone H3-S28 phosphorylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl] +synonym: "histone H3 phosphorylation at S28" EXACT [] +synonym: "histone H3S28 phosphorylation" EXACT [] +is_a: GO:0035404 ! histone-serine phosphorylation + +[Term] +id: GO:0043989 +name: histone H4-S1 phosphorylation +namespace: biological_process +def: "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] +synonym: "histone H4 phosphorylation at S1" EXACT [] +synonym: "histone H4S1 phosphorylation" EXACT [] +is_a: GO:0035404 ! histone-serine phosphorylation + +[Term] +id: GO:0043990 +name: histone H2A-S1 phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl] +synonym: "histone H2A phosphorylation at S1" EXACT [] +synonym: "histone H2AS1 phosphorylation" EXACT [] +is_a: GO:0035404 ! histone-serine phosphorylation +is_a: GO:1990164 ! histone H2A phosphorylation + +[Term] +id: GO:0043991 +name: histone H2B-S14 phosphorylation +namespace: biological_process +def: "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl] +synonym: "histone H2B phosphorylation at S14" EXACT [] +synonym: "histone H2BS14 phosphorylation" EXACT [] +is_a: GO:0035404 ! histone-serine phosphorylation + +[Term] +id: GO:0043992 +name: histone acetyltransferase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K9 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0043993 +name: histone acetyltransferase activity (H3-K18 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K18 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0043994 +name: histone acetyltransferase activity (H3-K23 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K23 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0043995 +name: histone acetyltransferase activity (H4-K5 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H4-K5 specific)" EXACT [] +is_a: GO:0010485 ! H4 histone acetyltransferase activity + +[Term] +id: GO:0043996 +name: histone acetyltransferase activity (H4-K8 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H4-K8 specific)" EXACT [] +is_a: GO:0010485 ! H4 histone acetyltransferase activity + +[Term] +id: GO:0043997 +name: histone acetyltransferase activity (H4-K12 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H4-K12 specific)" EXACT [] +is_a: GO:0010485 ! H4 histone acetyltransferase activity + +[Term] +id: GO:0043998 +name: H2A histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48] +synonym: "H2A histone lysine N-acetyltransferase activity" EXACT [] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0043999 +name: histone acetyltransferase activity (H2A-K5 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H2A-K5 specific)" EXACT [] +is_a: GO:0043998 ! H2A histone acetyltransferase activity + +[Term] +id: GO:0044000 +name: movement in host +namespace: biological_process +def: "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "movement of symbiont in host" EXACT [] +synonym: "movement of symbiont within host" EXACT [] +synonym: "movement within host" EXACT [] +synonym: "symbiont movement in host" EXACT [] +synonym: "symbiont movement within host" RELATED [] +is_a: GO:0052126 ! movement in host environment + +[Term] +id: GO:0044001 +name: migration in host +namespace: biological_process +def: "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "migration within host" EXACT [] +is_a: GO:0044000 ! movement in host + +[Term] +id: GO:0044002 +name: acquisition of nutrients from host +namespace: biological_process +def: "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0044003 +name: modulation by symbiont of host process +namespace: biological_process +alt_id: GO:0044004 +alt_id: GO:0044055 +def: "The process in which a symbiont organism effects a change in the structure or processes of its host organism." [GOC:cc] +synonym: "disruption by symbiont of host cell" RELATED [] +synonym: "modification by symbiont of host biological process" RELATED [] +synonym: "modification by symbiont of host morphology or physiology" RELATED [] +synonym: "modulation by symbiont of host system process" NARROW [] +synonym: "pathogenesis" RELATED [] +synonym: "regulation by symbiont of host system process" NARROW [] +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0044007 +name: obsolete dissemination or transmission of symbiont from host +namespace: biological_process +def: "OBSOLETE. The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont. +synonym: "dissemination or transmission of organism from host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044008 +name: obsolete dissemination or transmission of symbiont from host by vector +namespace: biological_process +def: "OBSOLETE. The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont. +synonym: "dissemination or transmission of organism from host by vector" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044009 +name: obsolete viral transmission by vector +namespace: biological_process +def: "OBSOLETE. The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a virus. +is_obsolete: true + +[Term] +id: GO:0044010 +name: single-species biofilm formation +namespace: biological_process +alt_id: GO:0052000 +def: "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb] +synonym: "auto-aggregation" BROAD [] +synonym: "bfp-dependent aggregation" NARROW [] +synonym: "bundle-forming fimbriae-dependent aggregation" NARROW [] +synonym: "bundle-forming pili-dependent aggregation" NARROW [] +synonym: "tfp-dependent aggregation" NARROW [] +synonym: "type IV pili-dependent aggregation" NARROW [] +is_a: GO:0042710 ! biofilm formation +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms + +[Term] +id: GO:0044011 +name: single-species biofilm formation on inanimate substrate +namespace: biological_process +def: "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc] +is_a: GO:0090609 ! single-species submerged biofilm formation + +[Term] +id: GO:0044012 +name: histone acetyltransferase activity (H2A-K9 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H2A-K9 specific)" EXACT [] +is_a: GO:0043998 ! H2A histone acetyltransferase activity + +[Term] +id: GO:0044013 +name: H2B histone acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48] +synonym: "H2B histone lysine N-acetyltransferase activity" EXACT [] +is_a: GO:0004402 ! histone acetyltransferase activity + +[Term] +id: GO:0044014 +name: histone acetyltransferase activity (H2B-K5 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H2B-K5 specific)" EXACT [] +is_a: GO:0044013 ! H2B histone acetyltransferase activity + +[Term] +id: GO:0044015 +name: histone acetyltransferase activity (H2B-K12 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H2B-K12 specific)" EXACT [] +is_a: GO:0044013 ! H2B histone acetyltransferase activity + +[Term] +id: GO:0044016 +name: histone acetyltransferase activity (H3-K4 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K4 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0044017 +name: histone acetyltransferase activity (H3-K27 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K27 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0044018 +name: histone acetyltransferase activity (H3-K36 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K36 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0044019 +name: histone acetyltransferase activity (H3-K72 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48] +synonym: "histone lysine N-acetyltransferase activity (H3-K72 specific)" EXACT [] +is_a: GO:0010484 ! H3 histone acetyltransferase activity + +[Term] +id: GO:0044020 +name: histone methyltransferase activity (H4-R3 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4." [GOC:mah, PMID:17898714] +synonym: "histone methylase activity (H4-R3 specific)" EXACT [GOC:mah] +synonym: "histone-arginine N-methyltransferase activity (H4-R3 specific)" EXACT [] +is_a: GO:0008469 ! histone-arginine N-methyltransferase activity + +[Term] +id: GO:0044022 +name: histone kinase activity (H3-S28 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl] +synonym: "histone serine kinase activity (H3-S28 specific)" EXACT [] +synonym: "histone-serine kinase activity (H3-S28 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0044023 +name: histone kinase activity (H4-S1 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl] +synonym: "histone serine kinase activity (H4-S1 specific)" EXACT [] +synonym: "histone-serine kinase activity (H4-S1 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0044024 +name: histone kinase activity (H2A-S1 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl] +synonym: "histone serine kinase activity (H2A-S1 specific)" EXACT [] +synonym: "histone-serine kinase activity (H2A-S1 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0044025 +name: histone kinase activity (H2B-S14 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B." [GOC:jl] +synonym: "histone serine kinase activity (H2B-S14 specific)" EXACT [] +synonym: "histone-serine kinase activity (H2B-S14 specific)" EXACT [] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0044026 +name: DNA hypermethylation +namespace: biological_process +def: "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/] +is_a: GO:0044030 ! regulation of DNA methylation + +[Term] +id: GO:0044027 +name: hypermethylation of CpG island +namespace: biological_process +def: "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] +synonym: "DNA hypermethylation of CpG island" EXACT [] +is_a: GO:0044026 ! DNA hypermethylation + +[Term] +id: GO:0044028 +name: DNA hypomethylation +namespace: biological_process +def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation] +is_a: GO:0044030 ! regulation of DNA methylation + +[Term] +id: GO:0044029 +name: hypomethylation of CpG island +namespace: biological_process +def: "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island] +synonym: "DNA hypomethylation of CpG island" EXACT [] +is_a: GO:0044028 ! DNA hypomethylation + +[Term] +id: GO:0044030 +name: regulation of DNA methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006306 ! DNA methylation + +[Term] +id: GO:0044031 +name: obsolete modification by symbiont of host protein by phosphorylation +namespace: biological_process +def: "OBSOLETE. The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0044032 +name: modulation by symbiont of indole acetic acid levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'. +synonym: "modulation by symbiont of auxin levels in host" BROAD [] +synonym: "modulation by symbiont of IAA levels in host" EXACT [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0044033 +name: obsolete multi-organism metabolic process +namespace: biological_process +def: "OBSOLETE. A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi-organism metabolism" EXACT [] +synonym: "multi-organismal metabolic process" EXACT [] +synonym: "multi-organismal metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044034 +name: obsolete multi-organism biosynthetic process +namespace: biological_process +def: "OBSOLETE. A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi-organism biosynthesis" EXACT [] +synonym: "multi-organismal biosynthesis" EXACT [] +synonym: "multi-organismal biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044035 +name: obsolete multi-organism catabolic process +namespace: biological_process +def: "OBSOLETE. A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi-organism catabolism" EXACT [] +synonym: "multi-organismal catabolic process" EXACT [] +synonym: "multi-organismal catabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044036 +name: cell wall macromolecule metabolic process +namespace: biological_process +alt_id: GO:0010382 +def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah] +synonym: "cellular cell wall macromolecule metabolic process" EXACT [] +synonym: "cellular cell wall macromolecule metabolism" EXACT [] +is_a: GO:0044260 ! cellular macromolecule metabolic process +relationship: part_of GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0044037 +name: obsolete multi-organism cell wall macromolecule metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi-organism cell wall macromolecule metabolism" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0044038 +name: cell wall macromolecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators] +synonym: "cell wall macromolecule anabolism" EXACT [GOC:mah] +synonym: "cell wall macromolecule biosynthesis" EXACT [GOC:mah] +synonym: "cell wall macromolecule biosynthetic process at cellular level" EXACT [GOC:mah] +synonym: "cell wall macromolecule synthesis" EXACT [GOC:mah] +synonym: "cellular cell wall macromolecule biosynthetic process" EXACT [GOC:mah] +is_a: GO:0044036 ! cell wall macromolecule metabolic process +is_a: GO:0070589 ! cellular component macromolecule biosynthetic process +relationship: part_of GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0044040 +name: obsolete multi-organism carbohydrate metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "main pathways of carbohydrate metabolic process" NARROW [] +synonym: "main pathways of carbohydrate metabolism" NARROW [] +synonym: "multi-organism carbohydrate metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044041 +name: obsolete multi-organism carbohydrate catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi-organism carbohydrate breakdown" EXACT [] +synonym: "multi-organism carbohydrate catabolism" EXACT [] +synonym: "multi-organism carbohydrate degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044042 +name: glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] +synonym: "glucan metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process + +[Term] +id: GO:0044043 +name: obsolete multi-organism glucan metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence it exists. +synonym: "multi-organism glucan metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044044 +name: obsolete interaction with host via substance in symbiont surface +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process. +is_obsolete: true + +[Term] +id: GO:0044045 +name: obsolete interaction with host via substance in symbiont cell outer membrane +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: The reason for obsoletion is that these terms conflate a process and the mechanism of secretion of the compound mediating the process. +is_obsolete: true + +[Term] +id: GO:0044046 +name: obsolete interaction with host via substance released outside of symbiont +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk] +comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. +synonym: "interaction with host via substance released outside of symbiont cells" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044047 +name: obsolete interaction with host via protein secreted by type I secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0044048 +name: obsolete interaction with host via protein secreted by type V secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0044049 +name: obsolete interaction with host via protein secreted by type VI secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0044050 +name: obsolete interaction with host via substance released by sporangium lysis +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. +synonym: "interaction with host via substance released by lysis of symbiont sporangium" RELATED [] +synonym: "interaction with host via substance released by sporangia lysis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044051 +name: obsolete interaction with host via substance released by symbiont cytolysis +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk] +comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. +synonym: "interaction with host via substance released by cytolysis of symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044052 +name: obsolete interaction with host via substance released by membrane budding +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk] +comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. +synonym: "interaction with host via substance released by symbiont membrane budding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044053 +name: translocation of peptides or proteins into host cell cytoplasm +namespace: biological_process +def: "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk] +synonym: "translocation of symbiont peptides or proteins into host cell cytoplasm" EXACT [] +synonym: "transport of peptides or proteins into host cell cytoplasm" EXACT [] +is_a: GO:0042000 ! translocation of peptides or proteins into host + +[Term] +id: GO:0044056 +name: modulation by symbiont of host digestive system process +namespace: biological_process +def: "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk] +synonym: "regulation by symbiont of host digestive system process" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: regulates GO:0022600 ! digestive system process + +[Term] +id: GO:0044057 +name: regulation of system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0003008 ! system process + +[Term] +id: GO:0044058 +name: regulation of digestive system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0022600 ! digestive system process + +[Term] +id: GO:0044059 +name: modulation by symbiont of host endocrine process +namespace: biological_process +def: "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk] +synonym: "regulation by symbiont of host endocrine process" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +is_a: GO:0044060 ! regulation of endocrine process + +[Term] +id: GO:0044060 +name: regulation of endocrine process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl] +synonym: "regulation of endocrine system process" EXACT [] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0050886 ! endocrine process + +[Term] +id: GO:0044061 +name: obsolete modulation by symbiont of host excretion +namespace: biological_process +def: "OBSOLETE. The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation by symbiont of host excretion" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044062 +name: regulation of excretion +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl] +is_a: GO:0044057 ! regulation of system process +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0007588 ! excretion + +[Term] +id: GO:0044063 +name: modulation by symbiont of host nervous system process +namespace: biological_process +def: "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk] +synonym: "modulation by symbiont of host neurological system process" EXACT [] +synonym: "regulation by symbiont of host neurological system process" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: regulates GO:0050877 ! nervous system process + +[Term] +id: GO:0044064 +name: modulation by symbiont of host respiratory system process +namespace: biological_process +def: "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk] +synonym: "regulation by symbiont of host respiratory system process" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: regulates GO:0003016 ! respiratory system process + +[Term] +id: GO:0044065 +name: regulation of respiratory system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl] +is_a: GO:0043576 ! regulation of respiratory gaseous exchange +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0003016 ! respiratory system process + +[Term] +id: GO:0044066 +name: modification by symbiont of host cell nucleus +namespace: biological_process +def: "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk] +synonym: "modification by symbiont of host nucleus" EXACT [] +synonym: "modification of host cell nucleus by symbiont" EXACT [] +synonym: "modification of host nucleus by symbiont" EXACT [] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0044067 +name: modification by symbiont of host intercellular junctions +namespace: biological_process +def: "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk] +synonym: "modification of host intercellular junctions by symbiont" EXACT [] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0044068 +name: modulation by symbiont of host cellular process +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk] +synonym: "modulation of host cellular process by symbiont" EXACT [] +synonym: "regulation by symbiont of host cellular process" EXACT [] +synonym: "regulation of host cellular process by symbiont" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: regulates GO:0009987 ! cellular process + +[Term] +id: GO:0044069 +name: modulation by symbiont of host anion transport +namespace: biological_process +def: "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk] +synonym: "modification of host anion transport by symbiont" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0006820 ! anion transport + +[Term] +id: GO:0044070 +name: regulation of anion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] +is_a: GO:0043269 ! regulation of ion transport +relationship: regulates GO:0006820 ! anion transport + +[Term] +id: GO:0044071 +name: modulation by symbiont of host cell cycle +namespace: biological_process +def: "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk] +synonym: "modification by symbiont of host cell cycle" EXACT [] +synonym: "modulation of host cell cycle by symbiont" EXACT [] +synonym: "regulation by symbiont of host cell cycle" EXACT [] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0044068 ! modulation by symbiont of host cellular process + +[Term] +id: GO:0044072 +name: negative regulation by symbiont of host cell cycle +namespace: biological_process +def: "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0044071 ! modulation by symbiont of host cell cycle + +[Term] +id: GO:0044073 +name: modulation by symbiont of host translation +namespace: biological_process +def: "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] +synonym: "modification by symbiont of host translation" EXACT [] +synonym: "modulation of host translation by symbiont" EXACT [] +synonym: "regulation by symbiont of host translation" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0044068 ! modulation by symbiont of host cellular process + +[Term] +id: GO:0044074 +name: negative regulation by symbiont of host translation +namespace: biological_process +def: "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk] +synonym: "negative regulation of host translation by symbiont" EXACT [] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0044073 ! modulation by symbiont of host translation + +[Term] +id: GO:0044075 +name: modulation by symbiont of host vacuole organization +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] +synonym: "modulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] +synonym: "modulation by symbiont of host vacuole organisation" EXACT [GOC:mah] +synonym: "modulation of host vacuole organization by symbiont" EXACT [GOC:mah] +synonym: "regulation by symbiont of host vacuole organization" EXACT [GOC:mah] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:0044088 ! regulation of vacuole organization + +[Term] +id: GO:0044076 +name: positive regulation by symbiont of host vacuole organization +namespace: biological_process +def: "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk] +synonym: "positive regulation by symbiont of host vacuole biogenesis" RELATED [GOC:mah] +synonym: "positive regulation by symbiont of host vacuole organisation" EXACT [GOC:mah] +synonym: "positive regulation of host vacuole organization by symbiont" EXACT [] +is_a: GO:0044075 ! modulation by symbiont of host vacuole organization +is_a: GO:0044090 ! positive regulation of vacuole organization + +[Term] +id: GO:0044077 +name: modulation by symbiont of host receptor-mediated endocytosis +namespace: biological_process +def: "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] +synonym: "modulation of host receptor-mediated endocytosis by symbiont" EXACT [] +synonym: "regulation by symbiont of host receptor-mediated endocytosis" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis + +[Term] +id: GO:0044078 +name: positive regulation by symbiont of host receptor-mediated endocytosis +namespace: biological_process +def: "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk] +synonym: "positive regulation of host receptor-mediated endocytosis by symbiont" EXACT [] +is_a: GO:0044077 ! modulation by symbiont of host receptor-mediated endocytosis +is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis + +[Term] +id: GO:0044079 +name: modulation by symbiont of host neurotransmitter secretion +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism." [MITRE:tk] +synonym: "modification by symbiont of host neurotransmitter secretion" EXACT [] +synonym: "modulation of host neurotransmitter secretion by symbiont" EXACT [] +synonym: "regulation by symbiont of host neurotransmitter secretion" EXACT [] +is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission +relationship: regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0044080 +name: modulation by symbiont of host cGMP-mediated signal transduction +namespace: biological_process +def: "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk] +synonym: "modulation by symbiont of host cGMP-mediated signal transduction pathway" EXACT [] +synonym: "modulation by symbiont of host cGMP-mediated signaling" EXACT [] +synonym: "modulation by symbiont of host cGMP-mediated signalling" EXACT [] +synonym: "modulation of host cGMP-mediated signal transduction by symbiont" EXACT [] +synonym: "regulation by symbiont of host cGMP-mediated signal transduction" EXACT [] +is_a: GO:0010752 ! regulation of cGMP-mediated signaling +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0044081 +name: modulation by symbiont of host nitric oxide-mediated signal transduction +namespace: biological_process +def: "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk] +synonym: "modulation by symbiont of host nitric oxide mediated signal transduction" EXACT [] +synonym: "modulation of host nitric oxide-mediated signal transduction by symbiont" EXACT [] +synonym: "modulation of host nitric oxide-mediated signaling by symbiont" EXACT [] +synonym: "modulation of host nitric oxide-mediated signalling by symbiont" EXACT [] +synonym: "regulation by symbiont of host nitric oxide-mediated signal transduction" EXACT [] +is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0044082 +name: modulation by symbiont of host small GTPase mediated signal transduction +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk] +synonym: "modulation of host small GTPase mediated signal transduction by symbiont" EXACT [] +synonym: "regulation by symbiont of host small GTPase mediated signal transduction" EXACT [] +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0044083 +name: modulation by symbiont of host Rho protein signal transduction +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk] +synonym: "modulation by symbiont of host Rho protein mediated signal transduction" EXACT [] +synonym: "modulation by symbiont of host Rho protein-mediated signal transduction" EXACT [] +synonym: "modulation of host Rho protein signal transduction by symbiont" EXACT [] +synonym: "modulation of host Rho protein signaling by symbiont" EXACT [] +synonym: "modulation of host Rho protein signalling by symbiont" EXACT [] +synonym: "regulation by symbiont of host Rho protein signal transduction" EXACT [] +is_a: GO:0035023 ! regulation of Rho protein signal transduction +is_a: GO:0044082 ! modulation by symbiont of host small GTPase mediated signal transduction + +[Term] +id: GO:0044084 +name: host cell membrane pore complex +namespace: cellular_component +def: "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk] +synonym: "pore complex in host cell membrane" EXACT [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0033644 ! host cell membrane + +[Term] +id: GO:0044085 +name: cellular component biogenesis +namespace: biological_process +alt_id: GO:0071843 +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "cellular component biogenesis at cellular level" EXACT [] +is_a: GO:0071840 ! cellular component organization or biogenesis + +[Term] +id: GO:0044087 +name: regulation of cellular component biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0044088 +name: regulation of vacuole organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] +synonym: "regulation of vacuole biogenesis" RELATED [GOC:mah] +synonym: "regulation of vacuole organisation" EXACT [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007033 ! vacuole organization + +[Term] +id: GO:0044089 +name: positive regulation of cellular component biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0044090 +name: positive regulation of vacuole organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah] +synonym: "positive regulation of vacuole biogenesis" RELATED [GOC:mah] +synonym: "positive regulation of vacuole organisation" EXACT [GOC:mah] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0044088 ! regulation of vacuole organization +relationship: positively_regulates GO:0007033 ! vacuole organization + +[Term] +id: GO:0044091 +name: membrane biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] +is_a: GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0044092 +name: negative regulation of molecular function +namespace: biological_process +def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0044093 +name: positive regulation of molecular function +namespace: biological_process +def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0044094 +name: host cell nuclear part +namespace: cellular_component +def: "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_a: GO:0033646 ! host intracellular part +relationship: part_of GO:0042025 ! host cell nucleus + +[Term] +id: GO:0044095 +name: host cell nucleoplasm +namespace: cellular_component +def: "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd] +is_a: GO:0044094 ! host cell nuclear part + +[Term] +id: GO:0044096 +name: type IV pilus +namespace: cellular_component +def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators, PMID:28496159] +synonym: "TFP" EXACT [] +synonym: "type 4 pilus" EXACT [] +synonym: "type IV fimbriae" EXACT [] +is_a: GO:0009289 ! pilus + +[Term] +id: GO:0044097 +name: secretion by the type IV secretion system +namespace: biological_process +def: "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] +synonym: "secretion via the type IV secretion system" EXACT [] +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0044098 +name: DNA secretion by the type IV secretion system +namespace: biological_process +def: "The controlled release of DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators] +synonym: "DNA secretion via the type IV secretion system" EXACT [] +is_a: GO:0044097 ! secretion by the type IV secretion system + +[Term] +id: GO:0044099 +name: polar tube +namespace: cellular_component +def: "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0044100 +name: sporoplasm +namespace: cellular_component +def: "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921] +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0044101 +name: (R)-citramalyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA." [GOC:jl] +synonym: "Ccl" RELATED [] +synonym: "R-citramalyl-CoA lyase activity" EXACT [] +xref: EC:4.1.3.46 +xref: MetaCyc:RXN-8967 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0044102 +name: purine deoxyribosyltransferase activity +namespace: molecular_function +def: "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, PMID:11836245] +synonym: "PTD" RELATED [] +synonym: "purine 2'-deoxyribosyltransferase activity" EXACT [] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0044103 +name: L-arabinose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, PMID:16326697] +xref: EC:1.1.1.376 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0044104 +name: 2,5-dioxovalerate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [PMID:16835232, PMID:17202142] +synonym: "2,5-dioxopentanoate dehydrogenase (NAD+) activity" EXACT [] +synonym: "2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity" EXACT [] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0044105 +name: L-xylulose reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+." [PMID:14736891] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0044106 +name: cellular amine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0044107 +name: cellular alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044108 +name: cellular alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl] +is_a: GO:0044107 ! cellular alcohol metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0044109 +name: cellular alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl] +is_a: GO:0044107 ! cellular alcohol metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0044110 +name: obsolete growth involved in symbiotic interaction +namespace: biological_process +alt_id: GO:0044153 +def: "OBSOLETE. The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] +comment: This term has been obsoleted because it represents an assay for viability, not a real biological process. +synonym: "growth during symbiotic interaction" RELATED [GOC:dph] +synonym: "growth on or near surface of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "growth on or near surface of other organism involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0044111 +name: formation of structure involved in a symbiotic process +namespace: biological_process +alt_id: GO:0044115 +alt_id: GO:0044152 +def: "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators] +synonym: "development during symbiotic interaction" RELATED [GOC:dph] +synonym: "development involved in symbiotic interaction" RELATED [] +synonym: "development of symbiont during interaction with host" RELATED [GOC:dph] +synonym: "development of symbiont involved in interaction with host" RELATED [] +synonym: "development on or near surface of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "development on or near surface of other organism involved in symbiotic interaction" NARROW [] +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0044113 +name: obsolete development in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "development in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0044114 +name: development of symbiont in host +namespace: biological_process +alt_id: GO:0044122 +alt_id: GO:0044124 +def: "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701. +synonym: "development of symbiont in host intercellular space" NARROW [] +synonym: "development of symbiont in host vascular tissue" NARROW [] +is_a: GO:0044111 ! formation of structure involved in a symbiotic process + +[Term] +id: GO:0044118 +name: obsolete development of symbiont in host cell +namespace: biological_process +def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0044120 +name: obsolete development of symbiont in host vacuole +namespace: biological_process +def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring in a host vacuole. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "development of symbiont in host organelle" BROAD [] +is_obsolete: true + +[Term] +id: GO:0044126 +name: obsolete regulation of growth of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044127 +name: regulation of development of symbiont in host +namespace: biological_process +def: "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'regulation of growth or development of symbiont in host ; GO:0033665'. See also 'regulation of growth of symbiont in host ; GO:0044126'. +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +relationship: regulates GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0044128 +name: obsolete positive regulation of growth of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044129 +name: positive regulation of development of symbiont in host +namespace: biological_process +def: "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont in host ; GO:0033666'. See also 'positive regulation of growth of symbiont in host ; GO:0044128'. +is_a: GO:0044127 ! regulation of development of symbiont in host +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +relationship: positively_regulates GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0044130 +name: obsolete negative regulation of growth of symbiont in host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044131 +name: negative regulation of development of symbiont in host +namespace: biological_process +def: "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont in host ; GO:0033667'. See also 'negative regulation of growth of symbiont in host ; GO:0044130'. +is_a: GO:0044127 ! regulation of development of symbiont in host +is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process +relationship: negatively_regulates GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0044132 +name: obsolete development of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is this term represents both a process and a component. +is_obsolete: true + +[Term] +id: GO:0044133 +name: obsolete growth of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0044134 +name: obsolete development of symbiont on or near host phyllosphere +namespace: biological_process +def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is this term represents both a process and a component. +is_obsolete: true + +[Term] +id: GO:0044135 +name: obsolete growth of symbiont on or near host phyllosphere +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +is_obsolete: true + +[Term] +id: GO:0044136 +name: obsolete development of symbiont on or near host rhizosphere +namespace: biological_process +def: "OBSOLETE. The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is that this term represents both a process and a component +is_obsolete: true + +[Term] +id: GO:0044137 +name: obsolete growth of symbiont on or near host rhizosphere +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0044138 +name: obsolete modulation of development of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is this term represents both a process and a component. +is_obsolete: true + +[Term] +id: GO:0044139 +name: obsolete modulation of growth of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044140 +name: obsolete negative regulation of growth of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044141 +name: obsolete negative regulation of development of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is this term represents both a process and a component. +is_obsolete: true + +[Term] +id: GO:0044142 +name: obsolete positive regulation of growth of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +is_obsolete: true + +[Term] +id: GO:0044143 +name: obsolete positive regulation of development of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators] +comment: The reason for obsoletion is this term represents both a process and a component. +is_obsolete: true + +[Term] +id: GO:0044144 +name: obsolete modulation of growth of symbiont involved in interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +synonym: "modulation of growth of symbiont during interaction with host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0044145 +name: modulation of formation of structure involved in a symbiotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. +synonym: "modulation of development of symbiont during interaction with host" RELATED [GOC:dph] +synonym: "modulation of development of symbiont involved in interaction with host" RELATED [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0044111 ! formation of structure involved in a symbiotic process + +[Term] +id: GO:0044146 +name: obsolete negative regulation of growth of symbiont involved in interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +synonym: "negative regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0044147 +name: negative regulation of formation of structure involved in a symbiotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. +synonym: "negative regulation of development of symbiont during interaction with host" RELATED [GOC:dph] +synonym: "negative regulation of development of symbiont involved in interaction with host" RELATED [] +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0044111 ! formation of structure involved in a symbiotic process + +[Term] +id: GO:0044148 +name: obsolete positive regulation of growth of symbiont involved in interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term was obsoleted because it was partially redundant with other terms and its usage has been inconsistent. +synonym: "positive regulation of growth of symbiont during interaction with host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0044149 +name: positive regulation of formation of structure involved in a symbiotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators] +comment: This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. +synonym: "positive regulation of development of symbiont during interaction with host" RELATED [GOC:dph] +synonym: "positive regulation of development of symbiont involved in interaction with host" RELATED [] +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0044111 ! formation of structure involved in a symbiotic process + +[Term] +id: GO:0044150 +name: obsolete development of host on or near symbiont surface +namespace: biological_process +def: "OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] +comment: The reason for obsoletion is this term represents both a process and a component. +synonym: "development of organism on or near symbiont surface" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044151 +name: obsolete growth of host on or near symbiont surface +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "growth of organism on or near symbiont surface" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044154 +name: histone H3-K14 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708] +synonym: "histone H3 acetylation at K14" EXACT [] +synonym: "histone H3K14 acetylation" EXACT [] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0044155 +name: host caveola +namespace: cellular_component +def: "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0033644 ! host cell membrane + +[Term] +id: GO:0044156 +name: host cell junction +namespace: cellular_component +def: "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0020002 ! host cell plasma membrane + +[Term] +id: GO:0044157 +name: host cell projection +namespace: cellular_component +def: "A prolongation or process extending from a host cell, e.g. a flagellum or axon." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044158 +name: host cell wall +namespace: cellular_component +def: "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044159 +name: host thylakoid +namespace: cellular_component +def: "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044160 +name: host thylakoid membrane +namespace: cellular_component +def: "The pigmented membrane of any host thylakoid." [GOC:rph] +is_a: GO:0033644 ! host cell membrane +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0044159 ! host thylakoid + +[Term] +id: GO:0044161 +name: host cell cytoplasmic vesicle +namespace: cellular_component +def: "A vesicle formed of membrane or protein, found in the cytoplasm of a host cell." [GOC:rph] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044162 +name: host cell cytoplasmic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a host cell cytoplasmic vesicle." [GOC:rph] +is_a: GO:0033644 ! host cell membrane +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0044161 ! host cell cytoplasmic vesicle + +[Term] +id: GO:0044163 +name: host cytoskeleton +namespace: cellular_component +def: "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph] +is_a: GO:0033647 ! host intracellular organelle + +[Term] +id: GO:0044164 +name: host cell cytosol +namespace: cellular_component +def: "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl] +synonym: "host cytosol" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044165 +name: host cell endoplasmic reticulum +namespace: cellular_component +def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl] +synonym: "host endoplasmic reticulum" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044166 +name: host cell endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the host cell endoplasmic reticulum." [GOC:jl] +synonym: "host endoplasmic reticulum lumen" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0044165 ! host cell endoplasmic reticulum + +[Term] +id: GO:0044167 +name: host cell endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the host cell endoplasmic reticulum." [GOC:jl] +synonym: "host endoplasmic reticulum membrane" EXACT [] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0033645 ! host cell endomembrane system +relationship: part_of GO:0044165 ! host cell endoplasmic reticulum + +[Term] +id: GO:0044168 +name: host cell rough endoplasmic reticulum +namespace: cellular_component +def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl] +synonym: "host rough endoplasmic reticulum" EXACT [] +is_a: GO:0044165 ! host cell endoplasmic reticulum + +[Term] +id: GO:0044169 +name: host cell rough endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the host cell rough endoplasmic reticulum." [GOC:jl] +synonym: "host rough endoplasmic reticulum membrane" EXACT [] +is_a: GO:0044167 ! host cell endoplasmic reticulum membrane +relationship: part_of GO:0044168 ! host cell rough endoplasmic reticulum + +[Term] +id: GO:0044170 +name: host cell smooth endoplasmic reticulum +namespace: cellular_component +def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl] +synonym: "host smooth endoplasmic reticulum" EXACT [] +is_a: GO:0044165 ! host cell endoplasmic reticulum + +[Term] +id: GO:0044171 +name: host cell smooth endoplasmic reticulum membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the host cell smooth endoplasmic reticulum." [GOC:jl] +synonym: "host smooth endoplasmic reticulum membrane" EXACT [] +is_a: GO:0044167 ! host cell endoplasmic reticulum membrane +relationship: part_of GO:0044170 ! host cell smooth endoplasmic reticulum + +[Term] +id: GO:0044172 +name: host cell endoplasmic reticulum-Golgi intermediate compartment +namespace: cellular_component +def: "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl, GOC:pr] +synonym: "host cell ER-Golgi intermediate compartment" EXACT [] +synonym: "host ER-Golgi intermediate compartment" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044173 +name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl] +synonym: "host cell ER-Golgi intermediate compartment membrane" EXACT [] +synonym: "host endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] +synonym: "host ER-Golgi intermediate compartment membrane" EXACT [] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0044172 ! host cell endoplasmic reticulum-Golgi intermediate compartment + +[Term] +id: GO:0044174 +name: host cell endosome +namespace: cellular_component +def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl] +synonym: "host endosome" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044175 +name: host cell endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a host cell endosome." [GOC:jl] +synonym: "host endosome membrane" EXACT [] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0044174 ! host cell endosome + +[Term] +id: GO:0044176 +name: host cell filopodium +namespace: cellular_component +def: "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl] +synonym: "host filopodium" EXACT [] +is_a: GO:0044157 ! host cell projection + +[Term] +id: GO:0044177 +name: host cell Golgi apparatus +namespace: cellular_component +def: "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] +synonym: "host Golgi apparatus" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044178 +name: host cell Golgi membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus." [GOC:jl] +synonym: "host Golgi membrane" EXACT [] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0033645 ! host cell endomembrane system +relationship: part_of GO:0044177 ! host cell Golgi apparatus + +[Term] +id: GO:0044179 +name: hemolysis in another organism +namespace: biological_process +def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl] +subset: goslim_chembl +synonym: "hemolysis in other organism" EXACT [] +synonym: "hemolysis of cells in other organism" EXACT [GOC:bf] +synonym: "hemolysis of erythrocytes in other organism" EXACT [] +synonym: "hemolysis of RBCs in other organism" EXACT [] +synonym: "hemolysis of red blood cells in other organism" EXACT [] +is_a: GO:0051715 ! cytolysis in another organism + +[Term] +id: GO:0044180 +name: filamentous growth of a unicellular organism +namespace: biological_process +def: "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0044181 +name: filamentous growth of a multicellular organism +namespace: biological_process +def: "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] +is_a: GO:0030447 ! filamentous growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis + +[Term] +id: GO:0044182 +name: filamentous growth of a population of unicellular organisms +namespace: biological_process +def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] +is_a: GO:0030447 ! filamentous growth + +[Term] +id: GO:0044183 +name: protein folding chaperone +namespace: molecular_function +def: "Binding to a protein or a protein-containing complex to assist the protein folding process." [GOC:mtg_cambridge_2009] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +synonym: "chaperone activity" BROAD [] +synonym: "protein binding involved in protein folding" EXACT [] +xref: Reactome:R-HSA-9018785 "RHOBTB2 binds GTP" +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0044184 +name: host cell late endosome +namespace: cellular_component +def: "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl] +is_a: GO:0044174 ! host cell endosome + +[Term] +id: GO:0044185 +name: host cell late endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a host cell late endosome." [GOC:jl] +is_a: GO:0044175 ! host cell endosome membrane +relationship: part_of GO:0044184 ! host cell late endosome + +[Term] +id: GO:0044186 +name: host cell lipid droplet +namespace: cellular_component +def: "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl] +synonym: "host cell lipid adiposome" EXACT [] +synonym: "host cell lipid body" EXACT [] +synonym: "host cell lipid particle" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044187 +name: host cell lysosome +namespace: cellular_component +def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044188 +name: host cell lysosomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0044187 ! host cell lysosome + +[Term] +id: GO:0044189 +name: obsolete host cell microsome +namespace: cellular_component +def: "OBSOLETE. Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl] +comment: This term was obsoleted because it refers to a cell fractionation experimental result and not a bona fide cellular component. +synonym: "host cell microsomal membrane" EXACT [] +synonym: "host cell microsome" EXACT [] +is_obsolete: true +consider: GO:0033648 + +[Term] +id: GO:0044190 +name: host cell mitochondrial envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0033650 ! host cell mitochondrion + +[Term] +id: GO:0044191 +name: host cell mitochondrial membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0044190 ! host cell mitochondrial envelope + +[Term] +id: GO:0044192 +name: host cell mitochondrial inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl] +is_a: GO:0044191 ! host cell mitochondrial membrane + +[Term] +id: GO:0044193 +name: host cell mitochondrial outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope." [GOC:jl] +is_a: GO:0039661 ! host organelle outer membrane +is_a: GO:0044191 ! host cell mitochondrial membrane + +[Term] +id: GO:0044194 +name: cytolytic granule +namespace: cellular_component +def: "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758] +is_a: GO:0005764 ! lysosome + +[Term] +id: GO:0044195 +name: nucleoplasmic reticulum +namespace: cellular_component +def: "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685] +synonym: "nuclear channels" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0044196 +name: host cell nucleolus +namespace: cellular_component +def: "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl] +is_a: GO:0044094 ! host cell nuclear part + +[Term] +id: GO:0044197 +name: Rel homology domain binding +namespace: molecular_function +def: "Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [InterPro:IPR011539, Wikipedia:Rel_homology_domain] +synonym: "RHD binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0044198 +name: zf-TRAF domain binding +namespace: molecular_function +def: "Binding to a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293] +synonym: "TRAF-type zinc finger domain binding" EXACT [] +synonym: "zinc finger TRAF-type domain binding" EXACT [] +synonym: "zinc-finger-TRAF domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0044199 +name: host cell nuclear envelope +namespace: cellular_component +def: "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl] +is_a: GO:0044094 ! host cell nuclear part +relationship: part_of GO:0033645 ! host cell endomembrane system + +[Term] +id: GO:0044200 +name: host cell nuclear membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl] +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0044199 ! host cell nuclear envelope + +[Term] +id: GO:0044201 +name: host cell nuclear inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope." [GOC:jl] +is_a: GO:0044200 ! host cell nuclear membrane + +[Term] +id: GO:0044202 +name: host cell nuclear outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl] +is_a: GO:0039661 ! host organelle outer membrane +is_a: GO:0044200 ! host cell nuclear membrane + +[Term] +id: GO:0044203 +name: host cell nuclear lamina +namespace: cellular_component +def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl] +is_a: GO:0044094 ! host cell nuclear part +relationship: part_of GO:0044201 ! host cell nuclear inner membrane + +[Term] +id: GO:0044204 +name: host cell nuclear matrix +namespace: cellular_component +def: "The dense fibrillar network lying on the inner side of the host nuclear membrane." [GOC:jl] +is_a: GO:0044094 ! host cell nuclear part + +[Term] +id: GO:0044205 +name: 'de novo' UMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl] +synonym: "'de novo' UMP biosynthesis" EXACT [] +is_a: GO:0006222 ! UMP biosynthetic process + +[Term] +id: GO:0044206 +name: UMP salvage +namespace: biological_process +def: "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496] +synonym: "UMP biosynthesis via nucleoside salvage pathway" EXACT [] +synonym: "UMP biosynthetic process via nucleoside salvage pathway" EXACT [] +is_a: GO:0006222 ! UMP biosynthetic process +is_a: GO:0010138 ! pyrimidine ribonucleotide salvage + +[Term] +id: GO:0044207 +name: translation initiation ternary complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl] +synonym: "Met-tRNA/eIF2.GTP ternary complex" NARROW [] +synonym: "translation initiation (ternary) complex" EXACT [] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044208 +name: 'de novo' AMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601] +is_a: GO:0006167 ! AMP biosynthetic process + +[Term] +id: GO:0044209 +name: AMP salvage +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350] +synonym: "adenosine monophosphate salvage" EXACT [] +synonym: "AMP biosynthetic process via salvage pathway" EXACT [] +is_a: GO:0006167 ! AMP biosynthetic process +is_a: GO:0106380 ! purine ribonucleotide salvage + +[Term] +id: GO:0044210 +name: 'de novo' CTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916] +synonym: "'de novo' cytidine 5'-triphosphate biosynthetic process" EXACT [] +is_a: GO:0006241 ! CTP biosynthetic process + +[Term] +id: GO:0044211 +name: CTP salvage +namespace: biological_process +def: "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935] +synonym: "CTP biosynthetic process via salvage pathway" EXACT [] +synonym: "cytidine 5'-triphosphate salvage" EXACT [] +is_a: GO:0006241 ! CTP biosynthetic process +is_a: GO:0010138 ! pyrimidine ribonucleotide salvage + +[Term] +id: GO:0044214 +name: spanning component of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd] +comment: Proteins that span the membrane but have the bulk on one side of the membrane may be additionally annotated with a term of the form integral to X side of the plasma membrane. +synonym: "fully spanning plasma membrane" EXACT [] +synonym: "transmembrane" RELATED [GOC:mah] +is_a: GO:0005887 ! integral component of plasma membrane +is_a: GO:0089717 ! spanning component of membrane + +[Term] +id: GO:0044215 +name: obsolete other organism +namespace: cellular_component +def: "OBSOLETE. A secondary organism with which the first organism is interacting." [GOC:jl] +comment: This term was obsoleted because it represents an organism, which is outside the scope of GO. +is_obsolete: true + +[Term] +id: GO:0044216 +name: obsolete other organism cell +namespace: cellular_component +def: "OBSOLETE. A cell of a secondary organism with which the first organism is interacting." [GOC:jl] +comment: This term was obsoleted because cell (and therefore 'other organism cell') was considered outside the scope of GO. +is_obsolete: true + +[Term] +id: GO:0044217 +name: other organism part +namespace: cellular_component +def: "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0044218 +name: other organism cell membrane +namespace: cellular_component +alt_id: GO:0044279 +def: "The cell membrane of a secondary organism with which the first organism is interacting." [GOC:jl] +synonym: "foreign membrane" RELATED [] +synonym: "other organism membrane" BROAD [] +is_a: GO:0044217 ! other organism part + +[Term] +id: GO:0044219 +name: host cell plasmodesma +namespace: cellular_component +def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph, PMID:16903353] +is_a: GO:0044156 ! host cell junction + +[Term] +id: GO:0044220 +name: host cell perinuclear region of cytoplasm +namespace: cellular_component +def: "The host cell cytoplasm situated near, or occurring around, the host nucleus." [GOC:rph] +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0044221 +name: host cell synapse +namespace: cellular_component +def: "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044222 +name: anammoxosome +namespace: cellular_component +def: "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044223 +name: pirellulosome +namespace: cellular_component +def: "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044224 +name: juxtaparanode region of axon +namespace: cellular_component +def: "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359] +synonym: "juxta paranode axon" RELATED [NIF_Subcellular:sao1191319089] +synonym: "juxtaparanodal region" EXACT [] +synonym: "juxtaparanode" EXACT [] +xref: NIF_Subcellular:sao758620702 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044304 ! main axon + +[Term] +id: GO:0044225 +name: apical pole of neuron +namespace: cellular_component +def: "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860] +xref: NIF_Subcellular:sao1186862860 +is_a: GO:0060187 ! cell pole +relationship: part_of GO:0043025 ! neuronal cell body + +[Term] +id: GO:0044226 +name: basal pole of neuron +namespace: cellular_component +def: "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860] +xref: NIF_Subcellular:sao1186862860 +is_a: GO:0060187 ! cell pole +relationship: part_of GO:0043025 ! neuronal cell body + +[Term] +id: GO:0044227 +name: methane-oxidizing organelle +namespace: cellular_component +def: "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh] +synonym: "methane-oxidizing compartment" EXACT [] +synonym: "methanotroph intracytoplasmic membrane-bound compartment" EXACT [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044228 +name: host cell surface +namespace: cellular_component +def: "The external part of the host cell wall and/or host plasma membrane." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044229 +name: host cell periplasmic space +namespace: cellular_component +def: "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044230 +name: host cell envelope +namespace: cellular_component +def: "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044231 +name: host cell presynaptic membrane +namespace: cellular_component +alt_id: GO:0072556 +def: "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph] +synonym: "host cell pre-synaptic membrane" EXACT [] +synonym: "other organism pre-synaptic membrane" RELATED [] +synonym: "other organism presynaptic membrane" RELATED [] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0033644 ! host cell membrane +relationship: part_of GO:0044221 ! host cell synapse + +[Term] +id: GO:0044232 +name: organelle membrane contact site +namespace: cellular_component +def: "A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880] +synonym: "inter-organelle junction" NARROW [] +synonym: "interorganelle junction" NARROW [] +synonym: "MCS" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0044233 +name: mitochondria-associated endoplasmic reticulum membrane +namespace: cellular_component +def: "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461, PMID:22078959, PMID:29626751, PMID:29684109] +synonym: "endoplasmic reticulum-mitochondrion membrane contact site" EXACT [] +synonym: "ER-mitochondrion membrane contact site" EXACT [] +synonym: "MAM" RELATED [] +synonym: "mitochondria-associated ER membrane" EXACT [] +synonym: "mitochondria-associated membrane" EXACT [] +synonym: "mitochondria-endoplasmic reticulum (ER) contact" EXACT [PMID:29870872] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0044237 +name: cellular metabolic process +namespace: biological_process +def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] +subset: gocheck_do_not_annotate +synonym: "cellular metabolism" EXACT [] +synonym: "intermediary metabolism" RELATED [GOC:mah] +is_a: GO:0008152 ! metabolic process +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0044238 +name: primary metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] +subset: goslim_pir +synonym: "primary metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0044239 +name: obsolete salivary polysaccharide catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/] +comment: The reason for obsoletion is that this term represents the location of a process, which should be captured by the relation 'occurs in'. +synonym: "salivary polysaccharide breakdown" EXACT [] +synonym: "salivary polysaccharide catabolism" EXACT [] +synonym: "salivary polysaccharide degradation" EXACT [] +is_obsolete: true +consider: GO:0000272 + +[Term] +id: GO:0044241 +name: lipid digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044242 +name: cellular lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl] +synonym: "cellular lipid breakdown" EXACT [] +synonym: "cellular lipid catabolism" EXACT [] +synonym: "cellular lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0044245 +name: polysaccharide digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044247 +name: cellular polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [GOC:jl] +synonym: "cellular polysaccharide breakdown" EXACT [] +synonym: "cellular polysaccharide catabolism" EXACT [] +synonym: "cellular polysaccharide degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0044248 +name: cellular catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] +synonym: "cellular breakdown" EXACT [] +synonym: "cellular catabolism" EXACT [] +synonym: "cellular degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044249 +name: cellular biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] +synonym: "cellular anabolism" EXACT [] +synonym: "cellular biosynthesis" EXACT [] +synonym: "cellular formation" EXACT [] +synonym: "cellular synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044250 +name: negative regulation of metabolic activity involved in hibernation +namespace: biological_process +def: "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation] +synonym: "down regulation of metabolic activity during hibernation" RELATED [] +synonym: "down-regulation of metabolic activity during hibernation" RELATED [] +synonym: "downregulation of metabolic activity during hibernation" RELATED [] +synonym: "inhibition of metabolic activity during hibernation" NARROW [] +synonym: "negative regulation of metabolic activity during hibernation" RELATED [GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +relationship: part_of GO:0042750 ! hibernation + +[Term] +id: GO:0044251 +name: obsolete protein catabolic process by pepsin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/] +comment: The reason for obsoletion is that this term represents a specific gene product. +synonym: "protein breakdown by pepsin" EXACT [] +synonym: "protein degradation by pepsin" EXACT [] +is_obsolete: true +consider: GO:0030163 + +[Term] +id: GO:0044255 +name: cellular lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] +subset: goslim_pir +synonym: "cellular lipid metabolism" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044256 +name: protein digestion +namespace: biological_process +def: "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators] +is_a: GO:0007586 ! digestion + +[Term] +id: GO:0044257 +name: cellular protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl] +synonym: "cellular protein breakdown" EXACT [] +synonym: "cellular protein catabolism" EXACT [] +synonym: "cellular protein degradation" EXACT [] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:0044265 ! cellular macromolecule catabolic process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0044258 +name: intestinal lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/] +synonym: "intestinal lipid breakdown" EXACT [] +synonym: "intestinal lipid catabolism" EXACT [] +synonym: "intestinal lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0044260 +name: cellular macromolecule metabolic process +namespace: biological_process +alt_id: GO:0034960 +def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [GOC:mah] +synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "cellular macromolecule metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044262 +name: cellular carbohydrate metabolic process +namespace: biological_process +alt_id: GO:0006092 +def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] +synonym: "cellular carbohydrate metabolism" EXACT [] +synonym: "main pathways of carbohydrate metabolic process" NARROW [] +synonym: "main pathways of carbohydrate metabolism" NARROW [] +is_a: GO:0005975 ! carbohydrate metabolic process +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0044264 +name: cellular polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] +synonym: "cellular glycan metabolic process" EXACT [] +synonym: "cellular glycan metabolism" EXACT [] +synonym: "cellular polysaccharide metabolism" EXACT [] +is_a: GO:0005976 ! polysaccharide metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0044265 +name: cellular macromolecule catabolic process +namespace: biological_process +alt_id: GO:0034962 +def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [GOC:jl] +synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] +synonym: "cellular macromolecule breakdown" EXACT [] +synonym: "cellular macromolecule catabolism" EXACT [] +synonym: "cellular macromolecule degradation" EXACT [] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0044267 +name: cellular protein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] +synonym: "cellular protein metabolism" EXACT [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0044269 +name: glycerol ether catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl] +synonym: "glycerol ether breakdown" EXACT [] +synonym: "glycerol ether catabolism" EXACT [] +synonym: "glycerol ether degradation" EXACT [] +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0044270 +name: cellular nitrogen compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] +synonym: "nitrogen compound breakdown" BROAD [] +synonym: "nitrogen compound catabolism" BROAD [] +synonym: "nitrogen compound degradation" BROAD [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0044271 +name: cellular nitrogen compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] +synonym: "nitrogen compound anabolism" BROAD [] +synonym: "nitrogen compound biosynthesis" BROAD [] +synonym: "nitrogen compound formation" BROAD [] +synonym: "nitrogen compound synthesis" BROAD [] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0044272 +name: sulfur compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] +synonym: "sulfur biosynthesis" NARROW [] +synonym: "sulfur biosynthetic process" NARROW [] +synonym: "sulfur compound anabolism" EXACT [] +synonym: "sulfur compound biosynthesis" EXACT [] +synonym: "sulfur compound formation" EXACT [] +synonym: "sulfur compound synthesis" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0044273 +name: sulfur compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] +synonym: "sulfur catabolic process" NARROW [] +synonym: "sulfur catabolism" NARROW [] +synonym: "sulfur compound breakdown" EXACT [] +synonym: "sulfur compound catabolism" EXACT [] +synonym: "sulfur compound degradation" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0044248 ! cellular catabolic process + +[Term] +id: GO:0044275 +name: cellular carbohydrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] +synonym: "cellular carbohydrate breakdown" EXACT [] +synonym: "cellular carbohydrate catabolism" EXACT [] +synonym: "cellular carbohydrate degradation" EXACT [] +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0044277 +name: cell wall disassembly +namespace: biological_process +alt_id: GO:0060871 +def: "A process that results in the breakdown of the cell wall." [GOC:jl] +synonym: "cellular cell wall disassembly" EXACT [] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0071555 ! cell wall organization + +[Term] +id: GO:0044278 +name: cell wall disruption in another organism +namespace: biological_process +def: "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl] +synonym: "cell wall disruption in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044280 +name: subplasmalemmal coating +namespace: cellular_component +def: "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839] +xref: NIF_Subcellular:sao1938587839 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane + +[Term] +id: GO:0044281 +name: small molecule metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] +comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +synonym: "small molecule metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0044282 +name: small molecule catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] +comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. +synonym: "small molecule catabolism" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0044283 +name: small molecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] +comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. +synonym: "small molecule biosynthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0044284 +name: mitochondrial crista junction +namespace: cellular_component +def: "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane." [GOC:mcc, PMID:21944719, PMID:21987634, PMID:22009199] +synonym: "crista junction" EXACT [] +synonym: "cristae junction" EXACT [] +is_a: GO:0044232 ! organelle membrane contact site +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0044286 +name: peg and socket contact +namespace: cellular_component +def: "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898] +synonym: "ball and socket contact" EXACT [GOC:tfm, PMID:17591898] +xref: NIF_Subcellular:sao1943947957 +is_a: GO:0044291 ! cell-cell contact zone + +[Term] +id: GO:0044288 +name: puncta adhaerentia +namespace: cellular_component +def: "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430] +xref: NIF_Subcellular:sao257629430 +is_a: GO:0005915 ! zonula adherens + +[Term] +id: GO:0044289 +name: mitochondrial inner-outer membrane contact site +namespace: cellular_component +alt_id: GO:0044285 +def: "Sites of close apposition of the inner and outer mitochondrial membrane." [PMID:22009199] +synonym: "bridge contact site" RELATED [] +synonym: "contact site" BROAD [] +is_a: GO:0044232 ! organelle membrane contact site +relationship: part_of GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0044290 +name: mitochondrial intracristal space +namespace: cellular_component +def: "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414] +xref: NIF_Subcellular:sao508958414 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0044291 +name: cell-cell contact zone +namespace: cellular_component +def: "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018] +synonym: "cell cell contact zone" EXACT [] +xref: NIF_Subcellular:sao1299635018 +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0044292 +name: dendrite terminus +namespace: cellular_component +def: "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134] +synonym: "dendrite terminal" EXACT [] +synonym: "dendrite terminal specialization" RELATED [] +synonym: "terminal specialization" RELATED [NIF_Subcellular:sao28175134] +synonym: "terminal specialization of a dendrite" EXACT [] +xref: NIF_Subcellular:sao28175134 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:0044293 +name: dendriole +namespace: cellular_component +def: "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904] +xref: NIF_Subcellular:sao28175134 +xref: NIF_Subcellular:sao295057932 +is_a: GO:0044292 ! dendrite terminus + +[Term] +id: GO:0044294 +name: dendritic growth cone +namespace: cellular_component +def: "The migrating motile tip of a growing nerve cell dendrite." [GOC:jl] +synonym: "dendrite growth cone" EXACT [] +xref: NIF_Subcellular:sao1594955670 +is_a: GO:0030426 ! growth cone +is_a: GO:0044292 ! dendrite terminus + +[Term] +id: GO:0044295 +name: axonal growth cone +namespace: cellular_component +def: "The migrating motile tip of a growing nerve cell axon." [GOC:jl, NIF_Subcellular:sao203987954] +synonym: "axon growth cone" EXACT [] +xref: NIF_Subcellular:sao1594955670 +xref: NIF_Subcellular:sao203987954 +is_a: GO:0030426 ! growth cone + +[Term] +id: GO:0044296 +name: dendritic tuft +namespace: cellular_component +def: "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079] +synonym: "dendrite tuft" EXACT [] +xref: NIF_Subcellular:sao1340260079 +is_a: GO:0044292 ! dendrite terminus + +[Term] +id: GO:0044297 +name: cell body +namespace: cellular_component +def: "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators] +comment: Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. +synonym: "cell soma" EXACT [] +xref: FBbt:00005107 +xref: FMA:67301 +xref: Wikipedia:Cell_body +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0044298 +name: cell body membrane +namespace: cellular_component +def: "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd] +synonym: "cell soma membrane" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane +relationship: part_of GO:0044297 ! cell body + +[Term] +id: GO:0044299 +name: C-fiber +namespace: cellular_component +def: "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210] +synonym: "C-fibre" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090210 +is_a: GO:0030424 ! axon + +[Term] +id: GO:0044300 +name: cerebellar mossy fiber +namespace: cellular_component +def: "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209] +synonym: "cerebellar mossy fibre" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090209 +is_a: GO:0030424 ! axon + +[Term] +id: GO:0044301 +name: climbing fiber +namespace: cellular_component +def: "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203] +synonym: "climbing fibre" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090203 +is_a: GO:0030424 ! axon + +[Term] +id: GO:0044302 +name: dentate gyrus mossy fiber +namespace: cellular_component +def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709] +synonym: "dentate gyrus mossy fibre" EXACT [] +synonym: "granule cell axon" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090601 +is_a: GO:0030424 ! axon + +[Term] +id: GO:0044303 +name: axon collateral +namespace: cellular_component +def: "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754] +xref: NIF_Subcellular:sao1470140754 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:0044304 +name: main axon +namespace: cellular_component +def: "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044] +synonym: "axon shaft" RELATED [PMID:11264310, PMID:24312009] +synonym: "axon trunk" EXACT [] +synonym: "axonal shaft" RELATED [PMID:11264310, PMID:24312009] +xref: NIF_Subcellular:sao1596975044 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:0044305 +name: calyx of Held +namespace: cellular_component +def: "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805] +xref: NIF_Subcellular:sao1684283879 +is_a: GO:0043679 ! axon terminus + +[Term] +id: GO:0044306 +name: neuron projection terminus +namespace: cellular_component +def: "The specialized, terminal region of a neuron projection such as an axon or a dendrite." [GOC:jl] +synonym: "nerve terminal" RELATED [PMID:25972809, PMID:9650842] +synonym: "neuron projection terminal" EXACT [] +synonym: "neuron terminal specialization" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043005 ! neuron projection + +[Term] +id: GO:0044307 +name: dendritic branch +namespace: cellular_component +def: "A dendrite arising from another dendrite." [GOC:aruk, GOC:bc, NIF_Subcellular:sao884265541] +synonym: "dendrite branch" EXACT [] +synonym: "secondary dendrite" NARROW [PMID:25431552] +xref: NIF_Subcellular:sao884265541 +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0044308 +name: axonal spine +namespace: cellular_component +def: "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917] +synonym: "axon spine" EXACT [] +xref: NIF_Subcellular:sao18239917 +is_a: GO:0044309 ! neuron spine +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:0044309 +name: neuron spine +namespace: cellular_component +def: "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102] +synonym: "spine" BROAD [] +xref: NIF_Subcellular:sao1145756102 +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0044310 +name: osmiophilic body +namespace: cellular_component +def: "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0044311 +name: exoneme +namespace: cellular_component +def: "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0044312 +name: crystalloid +namespace: cellular_component +def: "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0044313 +name: protein K6-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0044314 +name: protein K27-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326] +synonym: "protein K27-linked polyubiquitination" EXACT [GOC:mah] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0044315 +name: protein secretion by the type VII secretion system +namespace: biological_process +def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390] +is_a: GO:0009306 ! protein secretion +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0044316 +name: cone cell pedicle +namespace: cellular_component +def: "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [PMID:10939333] +synonym: "cone pedicle" EXACT [] +is_a: GO:0043679 ! axon terminus + +[Term] +id: GO:0044317 +name: rod spherule +namespace: cellular_component +def: "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [PMID:26930660] +synonym: "rod cell spherule" EXACT [] +synonym: "rod photoreceptor spherule" EXACT [] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0044318 +name: L-aspartate:fumarate oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100] +comment: This is based on the finding that L-aspartate oxidase (NadB) of E. coli preferentially uses fumarate as the electron acceptor and does so under anaerobic conditions. The same enzyme uses oxygen as the electron acceptor under aerobic conditions. The EC conflates the two reactions in EC:1.4.3.16 (as they are catalyzed by the same enzyme). +xref: EC:1.4.3.16 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0044319 +name: wound healing, spreading of cells +namespace: biological_process +def: "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl] +synonym: "cell migration involved in wound healing epiboly" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0090505 ! epiboly involved in wound healing + +[Term] +id: GO:0044320 +name: cellular response to leptin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0044321 ! response to leptin + +[Term] +id: GO:0044321 +name: response to leptin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf] +synonym: "response to leptin stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0044322 +name: endoplasmic reticulum quality control compartment +namespace: cellular_component +def: "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579] +synonym: "ER quality control compartment" EXACT [] +synonym: "ER-derived quality control compartment" RELATED [] +synonym: "ERQC" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0044323 +name: retinoic acid-responsive element binding +namespace: molecular_function +def: "Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671] +synonym: "RARE binding" EXACT [] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0044324 +name: regulation of transcription involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0044325 +name: transmembrane transporter binding +namespace: molecular_function +def: "Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:BHF, GOC:jl, PMID:33199372] +subset: goslim_chembl +synonym: "ion channel binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0044326 +name: dendritic spine neck +namespace: cellular_component +def: "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln] +synonym: "neck" BROAD [NIF_Subcellular:sao1642908940] +synonym: "pedicle" RELATED [NIF_Subcellular:sao1642908940] +synonym: "spine neck" BROAD [NIF_Subcellular:sao1642908940] +xref: NIF_Subcellular:sao1642908940 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0044327 +name: dendritic spine head +namespace: cellular_component +def: "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:BHF, GOC:nln, GOC:rl] +synonym: "spine head" BROAD [NIF_Subcellular:sao952643730] +xref: NIF_Subcellular:sao952643730 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0044328 +name: canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of endothelial cell migration" EXACT [GOC:mah] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0010595 ! positive regulation of endothelial cell migration + +[Term] +id: GO:0044329 +name: canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cell-cell adhesion" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0022409 ! positive regulation of cell-cell adhesion + +[Term] +id: GO:0044330 +name: canonical Wnt signaling pathway involved in positive regulation of wound healing +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of wound healing" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of wound healing" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of wound healing" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0090303 ! positive regulation of wound healing + +[Term] +id: GO:0044331 +name: cell-cell adhesion mediated by cadherin +namespace: biological_process +def: "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0044332 +name: Wnt signaling pathway involved in dorsal/ventral axis specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf] +synonym: "Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] +synonym: "Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0009950 ! dorsal/ventral axis specification + +[Term] +id: GO:0044333 +name: Wnt signaling pathway involved in digestive tract morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl] +synonym: "Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] +synonym: "Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0044334 +name: canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of epithelial to mesenchymal transition" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0010718 ! positive regulation of epithelial to mesenchymal transition + +[Term] +id: GO:0044335 +name: canonical Wnt signaling pathway involved in neural crest cell differentiation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:0044336 +name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] +synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis" NARROW [] +synonym: "canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in negative regulation of apoptosis" EXACT [GOC:mah] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0043066 ! negative regulation of apoptotic process + +[Term] +id: GO:0044337 +name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptosis" NARROW [] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of apoptosis" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of apoptotic process" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0043065 ! positive regulation of apoptotic process + +[Term] +id: GO:0044338 +name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in mesenchymal stem cell differentiation" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0072497 ! mesenchymal stem cell differentiation + +[Term] +id: GO:0044339 +name: canonical Wnt signaling pathway involved in osteoblast differentiation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0044340 +name: canonical Wnt signaling pathway involved in regulation of cell proliferation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl] +synonym: "canonical Wnt receptor signaling pathway involved in regulation of cell proliferation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in regulation of cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in regulation of cell proliferation" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0008283 ! cell population proliferation +relationship: part_of GO:0042127 ! regulation of cell population proliferation + +[Term] +id: GO:0044341 +name: sodium-dependent phosphate transport +namespace: biological_process +def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl] +is_a: GO:0006817 ! phosphate ion transport + +[Term] +id: GO:0044342 +name: type B pancreatic cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] +synonym: "pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "pancreatic beta cell proliferation" EXACT [] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0044343 +name: canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf] +synonym: "canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" RELATED [] +synonym: "canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation" EXACT [GOC:signaling] +is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation +relationship: part_of GO:0061469 ! regulation of type B pancreatic cell proliferation + +[Term] +id: GO:0044344 +name: cellular response to fibroblast growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf] +synonym: "cellular response to FGF stimulus" EXACT [] +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:0071774 ! response to fibroblast growth factor + +[Term] +id: GO:0044345 +name: stromal-epithelial cell signaling involved in prostate gland development +namespace: biological_process +def: "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl, GOC:yaf] +synonym: "stromal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0044346 +name: fibroblast apoptotic process +namespace: biological_process +def: "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf] +synonym: "fibroblast apoptosis" NARROW [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0044347 +name: cell wall polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides." [GOC:mengo_curators] +synonym: "cell wall polysaccharide breakdown" EXACT [GOC:mah] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0016998 ! cell wall macromolecule catabolic process + +[Term] +id: GO:0044348 +name: plant-type cell wall cellulose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall." [GOC:mengo_curators] +synonym: "plant-type cell wall polysaccharide breakdown" EXACT [GOC:mah] +is_a: GO:0044347 ! cell wall polysaccharide catabolic process +is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process + +[Term] +id: GO:0044349 +name: DNA excision +namespace: biological_process +def: "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised." [GOC:jl] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0044350 +name: micropinocytosis +namespace: biological_process +alt_id: GO:1902540 +def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm." [PMID:14731589, PMID:14732047] +synonym: "clathrin-independent pinocytosis" BROAD [] +synonym: "single-organism micropinocytosis" RELATED [] +is_a: GO:0006907 ! pinocytosis + +[Term] +id: GO:0044351 +name: macropinocytosis +namespace: biological_process +alt_id: GO:1902538 +def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047] +synonym: "clathrin-independent pinocytosis" BROAD [] +synonym: "single-organism macropinocytosis" RELATED [] +is_a: GO:0006907 ! pinocytosis + +[Term] +id: GO:0044352 +name: pinosome +namespace: cellular_component +def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis." [PMID:14731589, PMID:14732047] +synonym: "pinocytic vesicle" EXACT [NIF_Subcellular:sao1925368674] +xref: NIF_Subcellular:sao1925368674 +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0044353 +name: micropinosome +namespace: cellular_component +def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis." [PMID:14731589, PMID:14732047] +is_a: GO:0044352 ! pinosome + +[Term] +id: GO:0044354 +name: macropinosome +namespace: cellular_component +def: "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis." [PMID:14732047] +is_a: GO:0044352 ! pinosome + +[Term] +id: GO:0044355 +name: clearance of foreign intracellular DNA +namespace: biological_process +alt_id: GO:0044356 +def: "A defense process that protects an organism from invading foreign DNA." [GO:jl, PMID:20062055] +synonym: "clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine" NARROW [] +is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids + +[Term] +id: GO:0044357 +name: regulation of rRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." [GOC:jl] +synonym: "regulation of ribosomal RNA stability" EXACT [] +is_a: GO:0043487 ! regulation of RNA stability +is_a: GO:1902374 ! regulation of rRNA catabolic process + +[Term] +id: GO:0044358 +name: envenomation resulting in hemorrhagic damage in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism." [PMID:10441379, PMID:20614020] +synonym: "envenomation resulting in hemorrhagic damage to other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044359 +name: modulation of molecular function in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl] +synonym: "modulation of molecular function in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044360 +name: modulation of voltage-gated potassium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl] +synonym: "modulation of voltage-gated potassium channel activity in other organism" EXACT [] +is_a: GO:0044363 ! modulation of potassium channel activity in another organism + +[Term] +id: GO:0044361 +name: negative regulation of voltage-gated potassium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl] +synonym: "negative regulation of voltage-gated potassium channel activity in other organism" EXACT [] +is_a: GO:0044360 ! modulation of voltage-gated potassium channel activity in another organism +is_a: GO:0044362 ! negative regulation of molecular function in another organism + +[Term] +id: GO:0044362 +name: negative regulation of molecular function in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl] +synonym: "negative regulation of molecular function in other organism" EXACT [] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0044359 ! modulation of molecular function in another organism + +[Term] +id: GO:0044363 +name: modulation of potassium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism." [GOC:jl] +synonym: "modulation of potassium channel activity in other organism" EXACT [] +is_a: GO:0044561 ! modulation of ion channel activity in another organism + +[Term] +id: GO:0044364 +name: disruption of cells of another organism +namespace: biological_process +def: "A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl] +synonym: "disruption of cells of other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044365 +name: envenomation resulting in modulation of platelet aggregation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in modulation of platelet aggregation in other organism" EXACT [] +synonym: "envenomation resulting in regulation of platelet aggregation in other organism" EXACT [] +is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism + +[Term] +id: GO:0044373 +name: cytokinin binding +namespace: molecular_function +def: "Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators." [GOC:jl] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0044374 +name: sequence-specific DNA binding, bending +namespace: molecular_function +def: "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw] +synonym: "DNA bending involving sequence-specific DNA binding" EXACT [] +is_a: GO:0008301 ! DNA binding, bending +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0044375 +name: regulation of peroxisome size +namespace: biological_process +def: "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0044376 +name: obsolete RNA polymerase II complex import to nucleus +namespace: biological_process +alt_id: GO:0098738 +def: "OBSOLETE. The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus." [GOC:dos, GOC:jl] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "DNA-directed RNA polymerase II core complex import into nucleus" EXACT [GO:0098738] +synonym: "DNA-directed RNA polymerase II core complex localization to nucleus" EXACT [] +synonym: "RNA polymerase II complex import into nucleus" EXACT [] +synonym: "RNA polymerase II complex localisation to nucleus" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0044377 +name: RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending +namespace: molecular_function +def: "Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:pg] +synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending" RELATED [] +synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding, bending" RELATED [] +synonym: "RNA polymerase II proximal promoter region sequence-specific DNA binding, bending" RELATED [] +synonym: "RNA polymerase II proximal promoter sequence-specific DNA binding, bending" RELATED [] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding +is_a: GO:0044374 ! sequence-specific DNA binding, bending + +[Term] +id: GO:0044378 +name: non-sequence-specific DNA binding, bending +namespace: molecular_function +def: "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079] +synonym: "DNA bending involving non-sequence-specific DNA binding" EXACT [] +is_a: GO:0008301 ! DNA binding, bending + +[Term] +id: GO:0044379 +name: protein localization to actin cortical patch +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704] +synonym: "protein localisation to actin cortical patch" EXACT [GOC:mah] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:1903119 ! protein localization to actin cytoskeleton + +[Term] +id: GO:0044380 +name: protein localization to cytoskeleton +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] +synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0044381 +name: glucose import in response to insulin stimulus +namespace: biological_process +def: "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [GOC:BHF, PMID:19079291] +synonym: "cellular glucose import in response to insulin stimulus" EXACT [] +is_a: GO:0046323 ! glucose import +relationship: part_of GO:0032869 ! cellular response to insulin stimulus + +[Term] +id: GO:0044382 +name: CLRC complex localization to heterochromatin +namespace: biological_process +def: "The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:jl] +synonym: "CLRC ubiquitin ligase complex localisation to heterochromatin" EXACT [GOC:mah] +synonym: "CLRC ubiquitin ligase complex localization to heterochromatin" EXACT [] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0097355 ! protein localization to heterochromatin + +[Term] +id: GO:0044383 +name: host chromosome +namespace: cellular_component +def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell." [GOC:jl] +is_a: GO:0033647 ! host intracellular organelle + +[Term] +id: GO:0044384 +name: host outer membrane +namespace: cellular_component +def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell." [GOC:jl] +comment: This term covers the outer membrane of the host cell envelope or the outer membrane of a host organelle. For the outer layer of the host cell envelope specifically, see host cell outer membrane ; GO:0039662. +synonym: "host cell outer membrane" RELATED [GOC:bf] +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0044385 +name: integral to membrane of host cell +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell." [GOC:jl] +is_a: GO:0033643 ! host cell part +relationship: part_of GO:0033644 ! host cell membrane + +[Term] +id: GO:0044386 +name: integral to host endoplasmic reticulum membrane +namespace: cellular_component +def: "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell." [GOC:jl] +is_a: GO:0044385 ! integral to membrane of host cell +relationship: part_of GO:0044167 ! host cell endoplasmic reticulum membrane + +[Term] +id: GO:0044387 +name: negative regulation of protein kinase activity by regulation of protein phosphorylation +namespace: biological_process +def: "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase." [GOC:jl] +is_a: GO:0006469 ! negative regulation of protein kinase activity + +[Term] +id: GO:0044388 +name: small protein activating enzyme binding +namespace: molecular_function +def: "Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0044389 +name: ubiquitin-like protein ligase binding +namespace: molecular_function +def: "Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl] +synonym: "E3 protein ligase binding" EXACT [] +synonym: "small conjugating protein ligase binding" EXACT [GOC:dph] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0044390 +name: ubiquitin-like protein conjugating enzyme binding +namespace: molecular_function +def: "Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl] +synonym: "E2 protein ligase binding" EXACT [] +synonym: "small protein conjugating enzyme binding" EXACT [GOC:dph] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0044391 +name: ribosomal subunit +namespace: cellular_component +def: "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005840 ! ribosome + +[Term] +id: GO:0044392 +name: peptidyl-lysine malonylation +namespace: biological_process +def: "The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568] +synonym: "lysine malonylation" EXACT [PMID:21908771] +xref: RESID:AA0568 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0044394 ! protein malonylation + +[Term] +id: GO:0044393 +name: microspike +namespace: cellular_component +def: "A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735] +comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'. +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0044394 +name: protein malonylation +namespace: biological_process +def: "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [GOC:sp] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0044395 +name: protein targeting to vacuolar membrane +namespace: biological_process +def: "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein." [GOC:jl] +is_a: GO:0006612 ! protein targeting to membrane +is_a: GO:0006623 ! protein targeting to vacuole +is_a: GO:1903778 ! protein localization to vacuolar membrane + +[Term] +id: GO:0044396 +name: actin cortical patch organization +namespace: biological_process +def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl] +synonym: "actin cortical patch organisation" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0044397 +name: obsolete actin cortical patch internalization +namespace: biological_process +def: "OBSOLETE. A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah] +comment: The reason for obsoletion is that it represents a phenotype. +is_obsolete: true +replaced_by: GO:0006897 + +[Term] +id: GO:0044398 +name: envenomation resulting in induction of edema in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation." [GOC:jl, PMID:20562011] +synonym: "envenomation resulting in induction of edema in other organism" EXACT [] +synonym: "envenomation resulting in induction of oedema in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044399 +name: multi-species biofilm formation +namespace: biological_process +alt_id: GO:0044400 +alt_id: GO:0044401 +alt_id: GO:0090607 +alt_id: GO:0090608 +def: "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb] +synonym: "multi-species biofilm formation in or on host organism" NARROW [] +synonym: "multi-species biofilm formation on inanimate substrate" NARROW [] +synonym: "multi-species submerged biofilm formation" NARROW [] +synonym: "multi-species surface biofilm formation" RELATED [] +is_a: GO:0042710 ! biofilm formation +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0044402 +name: obsolete competition with other organism +namespace: biological_process +def: "OBSOLETE. Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc] +comment: This term was obsoleted because it is outside the scope of GO. +synonym: "competition with another organism" EXACT [GOC:bf] +synonym: "interspecies competition" BROAD [] +is_obsolete: true + +[Term] +id: GO:0044403 +name: biological process involved in symbiotic interaction +namespace: biological_process +alt_id: GO:0043298 +alt_id: GO:0044404 +alt_id: GO:0072519 +alt_id: GO:0085031 +def: "A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, PMID:31257129] +subset: goslim_chembl +synonym: "commensalism" NARROW [] +synonym: "host-pathogen interaction" NARROW [] +synonym: "parasitism" NARROW [] +synonym: "symbiosis" RELATED [] +synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] +synonym: "symbiotic interaction" RELATED [] +synonym: "symbiotic interaction between host and organism" RELATED [] +synonym: "symbiotic interaction between organisms" RELATED [] +synonym: "symbiotic interaction between species" RELATED [] +synonym: "symbiotic process" RELATED [] +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0044405 +name: detection of host +namespace: biological_process +def: "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "recognition of host" EXACT [] +is_a: GO:0075136 ! response to host +is_a: GO:0098543 ! detection of other organism + +[Term] +id: GO:0044406 +name: adhesion of symbiont to host +namespace: biological_process +alt_id: GO:0051825 +alt_id: GO:0051856 +def: "The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:cc, GOC:dos, GOC:jl] +comment: This term can be used to annotate both symbiont and host organisms. Consider also annotating to biological process involved in interaction with symbiont ; GO:0051702. +synonym: "adhesion to host" NARROW [] +synonym: "adhesion to other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "adhesion to other organism involved in symbiotic interaction" EXACT [] +synonym: "adhesion to symbiont" NARROW [] +synonym: "host adhesion" NARROW [] +is_a: GO:0022610 ! biological adhesion +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0044407 +name: single-species biofilm formation in or on host organism +namespace: biological_process +def: "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +is_a: GO:0044010 ! single-species biofilm formation +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0044408 +name: obsolete growth or development of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc] +synonym: "growth or development of organism on or near host surface" EXACT [] +synonym: "growth or development of symbiont on or near host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044409 +name: entry into host +namespace: biological_process +alt_id: GO:0030260 +alt_id: GO:0044411 +alt_id: GO:0051806 +alt_id: GO:0051828 +alt_id: GO:0051830 +alt_id: GO:0075052 +alt_id: GO:0085027 +alt_id: GO:0085028 +def: "Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:vw] +synonym: "entry into cell of other organism during symbiotic interaction" NARROW [GOC:tb] +synonym: "entry into cell of other organism involved in symbiotic interaction" RELATED [] +synonym: "entry into host cell" NARROW [] +synonym: "entry into host cell via penetration peg" NARROW [] +synonym: "entry into host through host barriers" RELATED [] +synonym: "entry into host via a specialized structure during symbiotic interaction" NARROW [] +synonym: "entry into host via enzymatic degradation of host anatomical structure" NARROW [] +synonym: "entry into host via enzymatic degradation of host cuticle" NARROW [] +synonym: "entry into other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "entry into other organism involved in symbiotic interaction" RELATED [] +synonym: "host cell invasion" NARROW [] +synonym: "host invasion" EXACT [] +synonym: "host penetration" EXACT [GOC:vw] +synonym: "invasion into host" EXACT [] +synonym: "invasion into other organism" RELATED [] +synonym: "invasion of host" EXACT [] +synonym: "invasion of other organism" RELATED [] +synonym: "invasive growth" RELATED [] +synonym: "other organism cell invasion" NARROW [] +synonym: "other organism invasion" RELATED [] +synonym: "penetration into host" EXACT [GOC:vw] +synonym: "penetration into host via a specialized structure" NARROW [GOC:vw] +synonym: "penetration into host via a specialized structure during symbiotic interaction" NARROW [GOC:vw] +is_a: GO:0052126 ! movement in host environment + +[Term] +id: GO:0044410 +name: obsolete entry into host through natural portals +namespace: biological_process +alt_id: GO:0051829 +def: "OBSOLETE. Penetration by a symbiont into a host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This is an unnecessary grouping term. +synonym: "entry into other organism through natural portals during symbiotic interaction" RELATED [GOC:tb] +synonym: "entry into other organism through natural portals involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0044412 +name: obsolete growth or development of symbiont in host +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development of organism within host" EXACT [] +synonym: "growth or development of symbiont in host" EXACT [] +synonym: "growth or development of symbiont within host" EXACT [] +synonym: "invasive growth" BROAD [] +is_obsolete: true +consider: GO:0044114 +consider: GO:0051701 + +[Term] +id: GO:0044414 +name: suppression of host defenses by symbiont +namespace: biological_process +alt_id: GO:0051833 +alt_id: GO:0052037 +alt_id: GO:0052261 +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "down regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] +synonym: "down regulation by symbiont of host defense response" EXACT [] +synonym: "down-regulation by organism of defense response of other organism during symbiotic interaction" RELATED [] +synonym: "down-regulation by symbiont of host defense response" EXACT [] +synonym: "downregulation by organism of defense response of other organism during symbiotic interaction" RELATED [] +synonym: "downregulation by symbiont of host defense response" EXACT [] +synonym: "inhibition by organism of defense response of other organism during symbiotic interaction" NARROW [] +synonym: "inhibition by symbiont of host defense response" NARROW [] +synonym: "negative regulation by organism of defense response of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "negative regulation by organism of defense response of other organism involved in symbiotic interaction" EXACT [] +synonym: "negative regulation by symbiont of host defense response" EXACT [] +synonym: "negative regulation of host defenses" EXACT [] +synonym: "suppression of defense response of other organism" EXACT [] +synonym: "suppression of defense response of other organism involved in symbiotic interaction" RELATED [] +synonym: "suppression of defenses of other organism involved in symbiotic interaction" BROAD [] +synonym: "suppression of host defense response" EXACT [] +is_a: GO:0030682 ! mitigation of host defenses by symbiont +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0044416 +name: induction by symbiont of host defense response +namespace: biological_process +alt_id: GO:0052251 +alt_id: GO:0052509 +alt_id: GO:0052510 +def: "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "activation by symbiont of host defense response" EXACT [] +synonym: "activation of host defense response" EXACT [] +synonym: "induction by organism of defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of host defense response" RELATED [] +synonym: "stimulation by symbiont of host defense response" RELATED [] +synonym: "up regulation by symbiont of host defense response" RELATED [] +synonym: "up-regulation by symbiont of host defense response" RELATED [] +synonym: "upregulation by symbiont of host defense response" RELATED [] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0044417 +name: translocation of molecules into host +namespace: biological_process +alt_id: GO:0051836 +def: "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "translocation of molecules into other organism during symbiotic interaction" BROAD [GOC:dph] +synonym: "translocation of molecules into other organism involved in symbiotic interaction" BROAD [] +synonym: "transport of molecules into host" EXACT [] +synonym: "transport of molecules into other organism during symbiotic interaction" BROAD [] +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0044418 +name: translocation of DNA into host +namespace: biological_process +alt_id: GO:0051837 +def: "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "translocation of DNA into other organism during symbiotic interaction" BROAD [GOC:tb] +synonym: "translocation of DNA into other organism involved in symbiotic interaction" BROAD [] +synonym: "transport of DNA into host" EXACT [] +synonym: "transport of DNA into other organism during symbiotic interaction" BROAD [] +is_a: GO:0044417 ! translocation of molecules into host + +[Term] +id: GO:0044419 +name: biological process involved in interspecies interaction between organisms +namespace: biological_process +def: "Any process evolved to enable an interaction with an organism of a different species." [GOC:cc] +subset: gocheck_do_not_annotate +subset: goslim_candida +subset: goslim_pir +synonym: "interaction with another species" EXACT [] +synonym: "interspecies interaction" EXACT [] +synonym: "interspecies interaction between organisms" EXACT [] +synonym: "interspecies interaction with other organisms" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0044420 +name: obsolete extracellular matrix component +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "extracellular matrix part" EXACT [] +is_obsolete: true +consider: GO:0031012 + +[Term] +id: GO:0044421 +name: obsolete extracellular region part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "extracellular structure" RELATED [NIF_Subcellular:sao9117790637] +xref: NIF_Subcellular:sao9117790637 +is_obsolete: true +consider: GO:0005576 + +[Term] +id: GO:0044422 +name: obsolete organelle part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0043226 + +[Term] +id: GO:0044423 +name: virion component +namespace: cellular_component +alt_id: GO:0019012 +def: "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl] +subset: goslim_chembl +subset: goslim_metagenomics +subset: goslim_pir +synonym: "complete virus particle" RELATED [] +synonym: "virion" RELATED [] +synonym: "virion part" EXACT [] +xref: Wikipedia:Virus +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0044424 +name: obsolete intracellular part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0005622 + +[Term] +id: GO:0044425 +name: obsolete membrane part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0016020 + +[Term] +id: GO:0044426 +name: obsolete cell wall part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0005618 + +[Term] +id: GO:0044427 +name: obsolete chromosomal part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "chromosomal component" EXACT [] +synonym: "chromosome component" EXACT [] +synonym: "chromosome part" EXACT [] +is_obsolete: true +consider: GO:0005694 + +[Term] +id: GO:0044428 +name: obsolete nuclear part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686] +synonym: "nucleus component" EXACT [] +xref: NIF_Subcellular:sao1499850686 +is_obsolete: true +consider: GO:0005634 + +[Term] +id: GO:0044429 +name: obsolete mitochondrial part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040] +synonym: "mitochondrion component" EXACT [] +xref: NIF_Subcellular:sao666410040 +is_obsolete: true +consider: GO:0005739 + +[Term] +id: GO:0044430 +name: obsolete cytoskeletal part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413] +synonym: "cytoskeleton component" EXACT [] +xref: NIF_Subcellular:sao1635329413 +is_obsolete: true +consider: GO:0005856 + +[Term] +id: GO:0044431 +name: obsolete Golgi apparatus part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "Golgi component" EXACT [] +synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949] +xref: NIF_Subcellular:sao624292949 +is_obsolete: true +consider: GO:0005794 + +[Term] +id: GO:0044432 +name: obsolete endoplasmic reticulum part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "ER component" EXACT [] +is_obsolete: true +consider: GO:0005783 + +[Term] +id: GO:0044433 +name: obsolete cytoplasmic vesicle part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0031410 + +[Term] +id: GO:0044434 +name: obsolete chloroplast part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0009507 + +[Term] +id: GO:0044435 +name: obsolete plastid part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0009536 + +[Term] +id: GO:0044436 +name: obsolete thylakoid part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0009579 + +[Term] +id: GO:0044437 +name: obsolete vacuolar part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "vacuole component" EXACT [] +is_obsolete: true +consider: GO:0005773 + +[Term] +id: GO:0044438 +name: obsolete microbody part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0042579 + +[Term] +id: GO:0044439 +name: obsolete peroxisomal part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "peroxisome component" EXACT [] +is_obsolete: true +consider: GO:0005777 + +[Term] +id: GO:0044440 +name: obsolete endosomal part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "endosomal subcomponent" EXACT [NIF_Subcellular:sao1683772610] +synonym: "endosome component" EXACT [] +xref: NIF_Subcellular:sao1683772610 +is_obsolete: true +consider: GO:0005768 + +[Term] +id: GO:0044441 +name: obsolete ciliary part +namespace: cellular_component +alt_id: GO:0044442 +def: "OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. +subset: gocheck_do_not_annotate +synonym: "cilial part" EXACT [] +synonym: "cilium part" EXACT [] +synonym: "flagellar part" NARROW [] +synonym: "flagellum component" NARROW [] +synonym: "flagellum part" NARROW [] +synonym: "microtubule-based flagellum part" EXACT [] +is_obsolete: true +consider: GO:0005929 + +[Term] +id: GO:0044443 +name: obsolete pilus part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "fimbrial part" EXACT [] +synonym: "fimbrium component" EXACT [] +synonym: "pilus component" EXACT [] +is_obsolete: true +consider: GO:0009289 + +[Term] +id: GO:0044444 +name: obsolete cytoplasmic part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "cytoplasm component" EXACT [] +is_obsolete: true +consider: GO:0005737 + +[Term] +id: GO:0044445 +name: obsolete cytosolic part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "cytosol component" EXACT [] +is_obsolete: true +consider: GO:0005829 + +[Term] +id: GO:0044446 +name: obsolete intracellular organelle part +namespace: cellular_component +def: "OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0043229 + +[Term] +id: GO:0044447 +name: obsolete axoneme part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:cilia, GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. +subset: gocheck_do_not_annotate +synonym: "axonemal part" EXACT [] +is_obsolete: true +consider: GO:0005930 + +[Term] +id: GO:0044448 +name: obsolete cell cortex part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0005938 + +[Term] +id: GO:0044449 +name: obsolete contractile fiber part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "contractile fibre component" EXACT [] +synonym: "muscle fiber component" BROAD [] +synonym: "muscle fibre component" BROAD [] +is_obsolete: true +consider: GO:0043292 + +[Term] +id: GO:0044450 +name: obsolete microtubule organizing center part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "microtubule organizing centre component" EXACT [] +synonym: "MTOC component" EXACT [] +is_obsolete: true +consider: GO:0005815 + +[Term] +id: GO:0044451 +name: obsolete nucleoplasm part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0005654 + +[Term] +id: GO:0044452 +name: obsolete nucleolar part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "nucleolus component" EXACT [] +is_obsolete: true +consider: GO:0005730 + +[Term] +id: GO:0044453 +name: obsolete nuclear membrane part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0031965 + +[Term] +id: GO:0044454 +name: obsolete nuclear chromosome part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0000228 + +[Term] +id: GO:0044455 +name: obsolete mitochondrial membrane part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0031966 + +[Term] +id: GO:0044456 +name: obsolete synapse part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "synaptic component" RELATED [NIF_Subcellular:sao1784069613] +xref: NIF_Subcellular:sao1784069613 +is_obsolete: true +consider: GO:0045202 + +[Term] +id: GO:0044457 +name: obsolete cell septum part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0030428 + +[Term] +id: GO:0044458 +name: motile cilium assembly +namespace: biological_process +alt_id: GO:1903887 +def: "The aggregation, arrangement and bonding together of a set of components to form a motile cilium." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:19776033, PMID:21129373, ZFIN:dsf] +synonym: "motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "motile primary cilium assembly" RELATED [] +synonym: "motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "nodal cilium formation" RELATED [GOC:TermGenie] +is_a: GO:0060271 ! cilium assembly + +[Term] +id: GO:0044459 +name: obsolete plasma membrane part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0005886 + +[Term] +id: GO:0044460 +name: obsolete flagellum part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl] +comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum part ; GO:0044461'. +synonym: "flagellum component" EXACT [] +synonym: "flagellum part" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044461 +name: obsolete bacterial-type flagellum part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the bacterial-type flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by a transmembrane ion potential, typically a proton or sodium potential." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, GOC:jl, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:25251856] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "flagellin-based flagellum part" EXACT [] +is_obsolete: true +consider: GO:0009288 + +[Term] +id: GO:0044462 +name: obsolete external encapsulating structure part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0030312 + +[Term] +id: GO:0044463 +name: obsolete cell projection part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0042995 + +[Term] +id: GO:0044464 +name: obsolete cell part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] +synonym: "protoplast" RELATED [GOC:mah] +xref: NIF_Subcellular:sao628508602 +is_obsolete: true +consider: CL:0000000 + +[Term] +id: GO:0044465 +name: modulation of sensory perception of pain in another organism +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism." [GOC:ed, PMID:18579526] +synonym: "modulation of sensory perception of pain in other organism" EXACT [] +synonym: "regulation of sensory perception of pain in another organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism +is_a: GO:0051930 ! regulation of sensory perception of pain + +[Term] +id: GO:0044466 +name: glutaryl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate." [GOC:pm, PMID:16141203] +synonym: "glutaryl-CoA thioesterase activity" EXACT [] +xref: EC:3.1.2.3 +is_a: GO:0047617 ! acyl-CoA hydrolase activity + +[Term] +id: GO:0044467 +name: glial cell-derived neurotrophic factor production +namespace: biological_process +def: "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307] +subset: gocheck_do_not_annotate +synonym: "GDNF production" EXACT [] +synonym: "glial cell line-derived neurotrophic factor production" RELATED [] +synonym: "glial cell-derived neurotrophic factor secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0044468 +name: envenomation resulting in modulation of blood coagulation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] +synonym: "envenomation resulting in modulation of blood coagulation in other organism" EXACT [] +synonym: "envenomation resulting in regulation of blood coagulation in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044469 +name: envenomation resulting in positive regulation of blood coagulation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] +synonym: "envenomation resulting in positive regulation of blood coagulation in other organism" EXACT [] +is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism +is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism + +[Term] +id: GO:0044470 +name: envenomation resulting in negative regulation of blood coagulation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl] +synonym: "envenomation resulting in negative regulation of blood coagulation in other organism" EXACT [] +is_a: GO:0044468 ! envenomation resulting in modulation of blood coagulation in another organism +is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism + +[Term] +id: GO:0044471 +name: envenomation resulting in pore formation in membrane of another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] +synonym: "envenomation resulting in pore formation in membrane of other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044472 +name: envenomation resulting in modulation of calcium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] +synonym: "envenomation resulting in modulation of calcium channel activity in other organism" EXACT [] +is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism + +[Term] +id: GO:0044473 +name: envenomation resulting in negative regulation of calcium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] +synonym: "envenomation resulting in negative regulation of calcium channel activity in other organism" EXACT [] +is_a: GO:0044472 ! envenomation resulting in modulation of calcium channel activity in another organism + +[Term] +id: GO:0044474 +name: envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] +synonym: "envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism" EXACT [] +is_a: GO:0044473 ! envenomation resulting in negative regulation of calcium channel activity in another organism + +[Term] +id: GO:0044475 +name: envenomation resulting in negative regulation of high voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] +synonym: "envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism" EXACT [] +is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism + +[Term] +id: GO:0044476 +name: envenomation resulting in negative regulation of low voltage-gated calcium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515] +synonym: "envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism" EXACT [] +is_a: GO:0044474 ! envenomation resulting in negative regulation of voltage-gated calcium channel activity in another organism + +[Term] +id: GO:0044477 +name: envenomation resulting in negative regulation of platelet aggregation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in negative regulation of platelet aggregation in other organism" EXACT [] +is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in another organism + +[Term] +id: GO:0044478 +name: envenomation resulting in positive regulation of platelet aggregation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in positive regulation of platelet aggregation in other organism" EXACT [] +is_a: GO:0044365 ! envenomation resulting in modulation of platelet aggregation in another organism +is_a: GO:0044469 ! envenomation resulting in positive regulation of blood coagulation in another organism + +[Term] +id: GO:0044479 +name: envenomation resulting in modulation of mast cell degranulation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] +synonym: "envenomation resulting in modulation of mast cell degranulation in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044480 +name: envenomation resulting in positive regulation of mast cell degranulation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739] +synonym: "envenomation resulting in positive regulation of mast cell degranulation in other organism" EXACT [] +is_a: GO:0044479 ! envenomation resulting in modulation of mast cell degranulation in another organism + +[Term] +id: GO:0044481 +name: envenomation resulting in proteolysis in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism." [GOC:fj, GOC:jl, PMID:15922779] +synonym: "envenomation resulting in proteolysis in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044482 +name: envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism." [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419] +synonym: "envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism" EXACT [] +synonym: "envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism" EXACT [] +is_a: GO:0044358 ! envenomation resulting in hemorrhagic damage in another organism + +[Term] +id: GO:0044483 +name: envenomation resulting in impairment of hemostasis in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in impairment of hemostasis in other organism" EXACT [] +synonym: "envenomation resulting in negative regulation of hemostasis in other organism" EXACT [] +synonym: "envenomation, impairing hemostasis in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044484 +name: envenomation resulting in fibrinolysis in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404] +synonym: "envenomation resulting in fibrinolysis in other organism" EXACT [] +is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism + +[Term] +id: GO:0044485 +name: envenomation resulting in fibrinogenolysis in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404] +synonym: "envenomation resulting in fibrinogenolysis in other organism" EXACT [] +is_a: GO:0044536 ! envenomation resulting in depletion of circulating fibrinogen in another organism + +[Term] +id: GO:0044486 +name: modulation of transmission of nerve impulse in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the transmission of a nerve impulse in another organism." [GOC:jl] +synonym: "modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph] +synonym: "modulation of transmission of nerve impulse in other organism" EXACT [] +synonym: "regulation of transmission of nerve impulse in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism +is_a: GO:0051969 ! regulation of transmission of nerve impulse + +[Term] +id: GO:0044487 +name: envenomation resulting in modulation of transmission of nerve impulse in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in modulation of conduction of nerve impulse in other organism" EXACT [GOC:dph] +synonym: "envenomation resulting in modulation of transmission of nerve impulse in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044488 +name: modulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "modulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044561 ! modulation of ion channel activity in another organism + +[Term] +id: GO:0044489 +name: negative regulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "negative regulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044362 ! negative regulation of molecular function in another organism +is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in another organism + +[Term] +id: GO:0044490 +name: positive regulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "positive regulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044488 ! modulation of voltage-gated sodium channel activity in another organism +is_a: GO:0044491 ! positive regulation of molecular function in another organism + +[Term] +id: GO:0044491 +name: positive regulation of molecular function in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl] +synonym: "positive regulation of molecular function in other organism" EXACT [] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0044359 ! modulation of molecular function in another organism + +[Term] +id: GO:0044492 +name: envenomation resulting in modulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "envenomation resulting in modulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism + +[Term] +id: GO:0044493 +name: envenomation resulting in negative regulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in another organism + +[Term] +id: GO:0044494 +name: envenomation resulting in positive regulation of voltage-gated sodium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281] +synonym: "envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism" EXACT [] +is_a: GO:0044492 ! envenomation resulting in modulation of voltage-gated sodium channel activity in another organism + +[Term] +id: GO:0044495 +name: modulation of blood pressure in another organism +namespace: biological_process +def: "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "modulation of blood pressure in other organism" EXACT [] +synonym: "regulation of blood pressure in other organism" EXACT [] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0044496 +name: negative regulation of blood pressure in another organism +namespace: biological_process +def: "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "negative regulation of blood pressure in other organism" EXACT [] +is_a: GO:0044495 ! modulation of blood pressure in another organism +is_a: GO:0045776 ! negative regulation of blood pressure + +[Term] +id: GO:0044497 +name: positive regulation of blood pressure in another organism +namespace: biological_process +def: "A process by which one organism increases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "positive regulation of blood pressure in other organism" EXACT [] +is_a: GO:0044495 ! modulation of blood pressure in another organism +is_a: GO:0045777 ! positive regulation of blood pressure + +[Term] +id: GO:0044498 +name: envenomation resulting in modulation of blood pressure in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "envenomation resulting in modulation of blood pressure in other organism" EXACT [] +synonym: "envenomation resulting in regulation of blood pressure in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044499 +name: envenomation resulting in positive regulation of blood pressure in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "envenomation resulting in positive regulation of blood pressure in other organism" EXACT [] +is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in another organism + +[Term] +id: GO:0044500 +name: envenomation resulting in negative regulation of blood pressure in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656] +synonym: "envenomation resulting in negative regulation of blood pressure in other organism" EXACT [] +synonym: "hypotensive activity in other organism" EXACT [] +is_a: GO:0044498 ! envenomation resulting in modulation of blood pressure in another organism + +[Term] +id: GO:0044501 +name: modulation of signal transduction in another organism +namespace: biological_process +def: "The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl] +synonym: "modulation of signal transduction in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044503 +name: modulation of G protein-coupled receptor activity in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "modulation of G protein-coupled receptor activity in other organism" EXACT [] +synonym: "modulation of G-protein coupled receptor activity in other organism" EXACT [] +is_a: GO:0044504 ! modulation of receptor activity in another organism + +[Term] +id: GO:0044504 +name: modulation of receptor activity in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "modulation of receptor activity in other organism" EXACT [] +is_a: GO:0044359 ! modulation of molecular function in another organism + +[Term] +id: GO:0044505 +name: positive regulation of G protein-coupled receptor activity in another organism +namespace: biological_process +def: "A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "positive regulation of G protein-coupled receptor activity in other organism" EXACT [] +synonym: "positive regulation of G-protein coupled receptor activity in other organism" EXACT [] +is_a: GO:0044503 ! modulation of G protein-coupled receptor activity in another organism +is_a: GO:0044507 ! positive regulation of receptor activity in another organism +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0044506 +name: modulation of glucagon-like peptide receptor 1 activity in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "modulation of glucagon-like peptide receptor 1 activity in other organism" EXACT [] +synonym: "regulation of glucagon-like peptide receptor activity in other organism" EXACT [] +is_a: GO:0044504 ! modulation of receptor activity in another organism + +[Term] +id: GO:0044507 +name: positive regulation of receptor activity in another organism +namespace: biological_process +def: "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "positive regulation of receptor activity in other organism" EXACT [] +is_a: GO:0044491 ! positive regulation of molecular function in another organism +is_a: GO:0044504 ! modulation of receptor activity in another organism + +[Term] +id: GO:0044508 +name: glucagon-like peptide 1 receptor activity +namespace: molecular_function +def: "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein." [GOC:jl, PMID:12529935] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0044509 +name: envenomation resulting in modulation of signal transduction in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in modulation of signal transduction in other organismm" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044510 +name: envenomation resulting in positive regulation of signal transduction in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in positive regulation of signal transduction in other organism" EXACT [] +is_a: GO:0044509 ! envenomation resulting in modulation of signal transduction in another organism + +[Term] +id: GO:0044511 +name: envenomation resulting in modulation of receptor activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in modulation of receptor activity in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044512 +name: envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism" EXACT [] +is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism + +[Term] +id: GO:0044513 +name: envenomation resulting in modulation of G protein-coupled receptor activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in modulation of G protein-coupled receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in modulation of G-protein coupled receptor activity in other organism" EXACT [] +is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism + +[Term] +id: GO:0044514 +name: envenomation resulting in positive regulation of G protein-coupled receptor activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism" EXACT [] +is_a: GO:0044513 ! envenomation resulting in modulation of G protein-coupled receptor activity in another organism + +[Term] +id: GO:0044515 +name: envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism" EXACT [] +is_a: GO:0044512 ! envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in another organism + +[Term] +id: GO:0044516 +name: positive regulation of glucagon-like peptide receptor 1 activity in another organism +namespace: biological_process +def: "A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712] +synonym: "positive regulation of glucagon-like peptide receptor 1 activity in other organism" EXACT [] +is_a: GO:0044506 ! modulation of glucagon-like peptide receptor 1 activity in another organism +is_a: GO:0044507 ! positive regulation of receptor activity in another organism + +[Term] +id: GO:0044517 +name: modulation of vasoactive intestinal polypeptide receptor activity in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl] +synonym: "modulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +synonym: "modulation of VIP receptor activity in other organism" EXACT [] +synonym: "regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +is_a: GO:0044504 ! modulation of receptor activity in another organism + +[Term] +id: GO:0044518 +name: positive regulation of vasoactive intestinal polypeptide receptor activity in another organism +namespace: biological_process +def: "A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl] +synonym: "positive regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +synonym: "positive regulation of VIP receptor activity in other organism" EXACT [] +is_a: GO:0044507 ! positive regulation of receptor activity in another organism +is_a: GO:0044517 ! modulation of vasoactive intestinal polypeptide receptor activity in another organism + +[Term] +id: GO:0044519 +name: envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in modulation of VIP receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in regulation of VIP receptor activity in other organism" EXACT [] +is_a: GO:0044511 ! envenomation resulting in modulation of receptor activity in another organism + +[Term] +id: GO:0044520 +name: envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism" EXACT [] +synonym: "envenomation resulting in positive regulation of VIP receptor activity in other organism" EXACT [] +is_a: GO:0044519 ! envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in another organism + +[Term] +id: GO:0044521 +name: envenomation resulting in muscle damage in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] +synonym: "envenomation resulting in muscle damage in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044522 +name: envenomation resulting in myocyte killing in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] +synonym: "envenomation resulting in myocyte killing causing muscle damage in other organism" EXACT [] +synonym: "envenomation resulting in myocyte killing in other organism" EXACT [] +is_a: GO:0044521 ! envenomation resulting in muscle damage in another organism + +[Term] +id: GO:0044523 +name: envenomation resulting in damage of muscle extracellular matrix in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580] +synonym: "envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism" EXACT [] +synonym: "envenomation resulting in damage of muscle extracellular matrix in other organism" EXACT [] +is_a: GO:0044521 ! envenomation resulting in muscle damage in another organism + +[Term] +id: GO:0044524 +name: protein sulfhydration +namespace: biological_process +def: "The modification of a protein amino acid by the addition of sulfur." [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0044525 +name: peptidyl-cystine sulfhydration +namespace: biological_process +def: "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] +is_a: GO:0044524 ! protein sulfhydration + +[Term] +id: GO:0044526 +name: formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine +namespace: biological_process +def: "The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] +is_a: GO:0044525 ! peptidyl-cystine sulfhydration + +[Term] +id: GO:0044527 +name: formation of peptidyl-cystine persulfide by sulphur transfer from H2S +namespace: biological_process +def: "The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg] +is_a: GO:0044525 ! peptidyl-cystine sulfhydration + +[Term] +id: GO:0044528 +name: regulation of mitochondrial mRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl] +is_a: GO:0043488 ! regulation of mRNA stability + +[Term] +id: GO:0044529 +name: regulation of mitochondrial rRNA stability +namespace: biological_process +def: "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs." [GOC:al, GOC:jl] +is_a: GO:0044357 ! regulation of rRNA stability + +[Term] +id: GO:0044530 +name: supraspliceosomal complex +namespace: cellular_component +def: "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing." [GOC:ans, GOC:jl, PMID:19282290] +synonym: "supraspliceosome complex" EXACT [] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0044532 +name: modulation of apoptotic process in another organism +namespace: biological_process +def: "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl] +synonym: "modulation of apoptotic process in other organism" EXACT [] +synonym: "regulation of apoptotic process in other organism" EXACT [] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:0051709 ! regulation of killing of cells of another organism + +[Term] +id: GO:0044533 +name: positive regulation of apoptotic process in another organism +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism." [GOC:jl, PMID:17983639] +synonym: "positive regulation of apoptotic process in other organism" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0044532 ! modulation of apoptotic process in another organism + +[Term] +id: GO:0044534 +name: envenomation resulting in modulation of apoptotic process in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism." [GOC:fj, GOC:jl, PMID:17983639] +synonym: "envenomation resulting in modulation of apoptotic process in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044535 +name: very-long-chain fatty acyl-CoA oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [PMID:17458872] +synonym: "very long chain fatty-acyl-CoA oxidase activity" EXACT [] +synonym: "very-long-chain acyl-CoA oxidase activity" EXACT [] +synonym: "VLC fatty-acyl-CoA oxidase activity" EXACT [] +xref: EC:1.3.3.- +is_a: GO:0003997 ! acyl-CoA oxidase activity + +[Term] +id: GO:0044536 +name: envenomation resulting in depletion of circulating fibrinogen in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in depletion of circulating fibrinogen in other organism" EXACT [] +synonym: "envenomation resulting in negative regulation of circulating fibrinogen in other organism" EXACT [] +is_a: GO:0044483 ! envenomation resulting in impairment of hemostasis in another organism +is_a: GO:0061754 ! negative regulation of circulating fibrinogen levels + +[Term] +id: GO:0044537 +name: regulation of circulating fibrinogen levels +namespace: biological_process +def: "Any process that modulates the quantity of fibrinogen circulating in the bloodstream." [GOC:jl] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0044538 +name: host cell periphery +namespace: cellular_component +def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell." [GOC:jl, PMID:20463076] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0044539 +name: long-chain fatty acid import into cell +namespace: biological_process +def: "The directed movement of a long-chain fatty acid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:jl, GOC:pm, PMID:22022213] +synonym: "long-chain fatty acid import" RELATED [] +synonym: "long-chain fatty acid uptake" EXACT [] +is_a: GO:0015909 ! long-chain fatty acid transport +is_a: GO:0140354 ! lipid import into cell + +[Term] +id: GO:0044540 +name: L-cystine L-cysteine-lyase (deaminating) +namespace: molecular_function +def: "Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24927] +xref: EC:4.4.1.1 +xref: KEGG_REACTION:R02408 +xref: RHEA:24927 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0044541 +name: zymogen activation in another organism +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism." [GOC:fj, GOC:jl] +synonym: "zymogen activation in other organism" EXACT [] +is_a: GO:0031638 ! zymogen activation + +[Term] +id: GO:0044542 +name: plasminogen activation in another organism +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism." [GOC:fj, GOC:jl] +synonym: "plasminogen activation in other organism" EXACT [] +is_a: GO:0031639 ! plasminogen activation +is_a: GO:0044541 ! zymogen activation in another organism + +[Term] +id: GO:0044543 +name: envenomation resulting in zymogen activation in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in zymogen activation in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044544 +name: envenomation resulting in plasminogen activation in another organism +namespace: biological_process +def: "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in plasminogen activation in other organism" EXACT [] +is_a: GO:0044484 ! envenomation resulting in fibrinolysis in another organism + +[Term] +id: GO:0044545 +name: NSL complex +namespace: cellular_component +def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852] +synonym: "non-specific lethal complex" EXACT [] +is_a: GO:1902562 ! H4 histone acetyltransferase complex + +[Term] +id: GO:0044546 +name: NLRP3 inflammasome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell." [GOC:jl, PMID:21048113] +synonym: "NALP3 inflammasome complex assembly" EXACT [] +synonym: "NLRP3 inflammasome activation" RELATED [] +is_a: GO:0140632 ! inflammasome complex assembly + +[Term] +id: GO:0044547 +name: DNA topoisomerase binding +namespace: molecular_function +alt_id: GO:0017033 +def: "Binding to a DNA topoisomerase." [GOC:jl] +synonym: "DNA topoisomerase I binding" NARROW [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0044548 +name: S100 protein binding +namespace: molecular_function +alt_id: GO:0048154 +alt_id: GO:0048155 +def: "Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] +synonym: "S100 alpha binding" NARROW [] +synonym: "S100 beta binding" NARROW [] +synonym: "S100 binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0044549 +name: GTP cyclohydrolase binding +namespace: molecular_function +alt_id: GO:0043106 +def: "Binding to a GTP cyclohydrolase." [GOC:jl] +synonym: "GTP cyclohydrolase I binding" NARROW [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0044550 +name: secondary metabolite biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl] +synonym: "secondary metabolite biosynthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0044551 +name: envenomation resulting in vasodilation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:21050868] +synonym: "envenomation resulting in modulation of vasodilation in other organism" RELATED [] +synonym: "envenomation resulting in regulation of vasodilation in other organism" RELATED [] +synonym: "envenomation resulting in vasodilation in other organism" EXACT [] +is_a: GO:0044500 ! envenomation resulting in negative regulation of blood pressure in another organism + +[Term] +id: GO:0044552 +name: vasodilation in another organism +namespace: biological_process +def: "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism." [GOC:ecd, GOC:jl, PMID:21050868] +synonym: "modulation of vasodilation in other organism" RELATED [] +synonym: "regulation of vasodilation in other organism" RELATED [] +synonym: "vasodilation in other organism" EXACT [] +is_a: GO:0042311 ! vasodilation +is_a: GO:0044553 ! modulation of biological quality in another organism + +[Term] +id: GO:0044553 +name: modulation of biological quality in another organism +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:jl] +synonym: "modulation of biological quality in other organism" EXACT [] +synonym: "regulation of biological quality in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044554 +name: modulation of heart rate in another organism +namespace: biological_process +def: "Any process that modulates the frequency or rate of heart contraction of another organism." [GOC:jl, PMID:20923766] +synonym: "modulation of heart rate in other organism" EXACT [] +synonym: "regulation of heart rate in other organism" EXACT [] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0044553 ! modulation of biological quality in another organism + +[Term] +id: GO:0044555 +name: negative regulation of heart rate in another organism +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency of heart contraction of another organism." [GOC:ecd, GOC:jl, PMID:20923766] +synonym: "negative regulation of heart rate in other organism" EXACT [] +is_a: GO:0010459 ! negative regulation of heart rate +is_a: GO:0044554 ! modulation of heart rate in another organism + +[Term] +id: GO:0044556 +name: envenomation resulting in negative regulation of heart rate in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:20923766] +synonym: "envenomation resulting in negative regulation of heart rate of other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044557 +name: relaxation of smooth muscle +namespace: biological_process +def: "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:jl] +synonym: "smooth muscle relaxation" EXACT [] +is_a: GO:0090075 ! relaxation of muscle + +[Term] +id: GO:0044558 +name: uterine smooth muscle relaxation +namespace: biological_process +def: "A process in which the extent of smooth muscle contraction is reduced in the uterus." [GOC:jl] +synonym: "smooth muscle relaxation of the uterus" EXACT [] +is_a: GO:0044557 ! relaxation of smooth muscle + +[Term] +id: GO:0044559 +name: envenomation resulting in modulation of voltage-gated potassium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in modulation of voltage-gated potassium channel activity in other organism" EXACT [] +is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism + +[Term] +id: GO:0044560 +name: envenomation resulting in modulation of ion channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in modulation of ion channel activity in other organism" EXACT [] +synonym: "envenomation resulting in regulation of ion channel activity in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044561 +name: modulation of ion channel activity in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism." [GOC:jl] +synonym: "modulation of ion channel activity in other organism" EXACT [] +synonym: "regulation of ion channel activity in other organism" EXACT [] +is_a: GO:0044359 ! modulation of molecular function in another organism + +[Term] +id: GO:0044562 +name: envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism" EXACT [] +is_a: GO:0044559 ! envenomation resulting in modulation of voltage-gated potassium channel activity in another organism + +[Term] +id: GO:0044563 +name: envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism" EXACT [] +synonym: "voltage-dependence of activation shift (to the left)" EXACT [] +is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism + +[Term] +id: GO:0044564 +name: envenomation resulting in occlusion of the pore of voltage-gated potassium channel in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism." [GOC:fj, GOC:jl] +synonym: "envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism" EXACT [] +is_a: GO:0044562 ! envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism + +[Term] +id: GO:0044565 +name: dendritic cell proliferation +namespace: biological_process +def: "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816] +is_a: GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0044566 +name: chondrocyte activation +namespace: biological_process +def: "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0044567 +name: primary cell wall cellulose synthase complex +namespace: cellular_component +def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein." [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367] +synonym: "primary cell wall CESA complex" EXACT [] +synonym: "primary cell-wall cellulose synthase complex" EXACT [] +is_a: GO:0010330 ! cellulose synthase complex + +[Term] +id: GO:0044568 +name: secondary cell wall cellulose synthase complex +namespace: cellular_component +def: "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4." [GOC:mengo_curators, GOC:tt, PMID:21307367] +synonym: "secondary cell wall CESA complex" EXACT [] +synonym: "secondary cell-wall cellulose synthase complex" EXACT [] +is_a: GO:0010330 ! cellulose synthase complex + +[Term] +id: GO:0044569 +name: [Ni-Fe] hydrogenase complex +namespace: cellular_component +def: "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer." [GOC:mengo_curators, GOC:tt, PMID:8936309] +synonym: "Ni-Fe hydrogenase complex" EXACT [] +synonym: "nickel-iron hydrogenase complex" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0044570 +name: starch utilization system complex +namespace: cellular_component +def: "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch." [GOC:mengo_curators, GOC:tt, PMID:19553672] +synonym: "Sus complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0044571 +name: [2Fe-2S] cluster assembly +namespace: biological_process +def: "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888] +synonym: "2Fe-2S cluster assembly" EXACT [] +synonym: "[2Fe-2S] cluster biosynthetic process" RELATED [] +is_a: GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:0044572 +name: [4Fe-4S] cluster assembly +namespace: biological_process +def: "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888] +synonym: "4Fe-4S cluster assembly" EXACT [] +synonym: "[4Fe-4S] cluster biosynthetic process" RELATED [] +is_a: GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:0044573 +name: nitrogenase P cluster assembly +namespace: biological_process +def: "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide." [PMID:17563349] +synonym: "nitrogenase P cluster biosynthesis" EXACT [] +synonym: "nitrogenase P cluster maturation" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:0044574 +name: starch utilization system complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452] +synonym: "assembly of starch utilization system complex" EXACT [] +synonym: "SUS complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0044575 +name: cellulosome assembly +namespace: biological_process +def: "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall." [GOC:mengo_curators, GOC:tt, PMID:20373916] +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0044576 +name: pentose catabolic process to ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt] +synonym: "pentose catabolism to ethanol" EXACT [] +is_a: GO:0006115 ! ethanol biosynthetic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:0044577 +name: xylose catabolic process to ethanol +namespace: biological_process +def: "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt] +synonym: "xylose catabolism to ethanol" EXACT [] +is_a: GO:0042843 ! D-xylose catabolic process +is_a: GO:0044576 ! pentose catabolic process to ethanol + +[Term] +id: GO:0044578 +name: butyryl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA." [GOC:jl] +synonym: "butyryl-CoA biosynthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process + +[Term] +id: GO:0044579 +name: butyryl-CoA biosynthetic process from acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA." [GOC:mengo_curators, GOC:tt, PMID:19539744] +synonym: "butyryl-CoA biosynthesis from acetyl-CoA" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0044578 ! butyryl-CoA biosynthetic process + +[Term] +id: GO:0044580 +name: butyryl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA." [GOC:jl] +synonym: "butyryl-CoA catabolism" EXACT [] +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process + +[Term] +id: GO:0044581 +name: butyryl-CoA catabolic process to butyrate +namespace: biological_process +def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate." [GOC:mengo_curators, GOC:tt, PMID:19539744] +synonym: "butyryl-CoA catabolism to butyrate" EXACT [] +is_a: GO:0044580 ! butyryl-CoA catabolic process +is_a: GO:0046358 ! butyrate biosynthetic process + +[Term] +id: GO:0044582 +name: butyryl-CoA catabolic process to butanol +namespace: biological_process +def: "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol." [GOC:mengo_curators, GOC:tt, PMID:19539744] +synonym: "butyryl-CoA catabolism to butanol" EXACT [] +is_a: GO:0044580 ! butyryl-CoA catabolic process +is_a: GO:0071271 ! 1-butanol biosynthetic process + +[Term] +id: GO:0044583 +name: cellotriose binding +namespace: molecular_function +def: "Binding to cellotriose." [GOC:mengo_curators, GOC:tt] +is_a: GO:0048031 ! trisaccharide binding + +[Term] +id: GO:0044584 +name: cellodextrin binding +namespace: molecular_function +def: "Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers." [GOC:mengo_curators, GOC:tt, PMID:18952792] +is_a: GO:0030247 ! polysaccharide binding +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0044585 +name: cellobiose binding +namespace: molecular_function +def: "Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose." [GOC:mengo_curators, GOC:tt] +is_a: GO:0048030 ! disaccharide binding + +[Term] +id: GO:0044586 +name: cellotetraose binding +namespace: molecular_function +def: "Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0044587 +name: cellopentaose binding +namespace: molecular_function +def: "Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0044588 +name: laminaribiose binding +namespace: molecular_function +def: "Binding to laminaribiose, a disaccharide." [GOC:mengo_curators, GOC:tt] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0044589 +name: pectin binding +namespace: molecular_function +def: "Binding to pectin." [GOC:mengo_curators, GOC:tt] +is_a: GO:0048028 ! galacturonan binding + +[Term] +id: GO:0044590 +name: iron-sulfur-molybdenum cofactor binding +namespace: molecular_function +def: "Binding to iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691] +synonym: "FeMo co binding" EXACT [] +synonym: "FeMoco binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0044591 +name: response to amylopectin +namespace: biological_process +def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus." [GOC:mengo_curators, GOC:tt] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0044592 +name: response to pullulan +namespace: biological_process +def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus." [GOC:mengo_curators, GOC:tt] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0044593 +name: iron-sulfur-molybdenum cofactor assembly +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691] +synonym: "FeMoco assembly" EXACT [] +synonym: "FeMoco biosynthetic process" EXACT [] +synonym: "iron molybdenum cofactor assembly" EXACT [] +synonym: "iron molybdenum cofactor biosynthesis" EXACT [] +synonym: "iron molybdenum cofactor biosynthetic process" EXACT [] +is_a: GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:0044594 +name: 17-beta-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+." [PMID:17074428] +xref: RHEA:24612 +is_a: GO:0004303 ! estradiol 17-beta-dehydrogenase activity + +[Term] +id: GO:0044595 +name: decaprenyldihydroxybenzoate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate." [PMID:10777520] +xref: MetaCyc:RXN-9282 +xref: Reactome:R-HSA-2162193 "DHDB is methylated to MHDB by COQ3" +xref: RHEA:44492 +is_a: GO:0010420 ! 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity + +[Term] +id: GO:0044596 +name: 3-demethylubiquinol-10 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10." [PMID:10777520] +xref: MetaCyc:RXN-9237 +xref: Reactome:R-HSA-2162186 "DeMQ10H2 is methylated to Q10H2 by COQ3" +xref: RHEA:44412 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity +is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity + +[Term] +id: GO:0044597 +name: daunorubicin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer." [PMID:20837989] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:0044598 +name: doxorubicin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy." [PMID:10200167] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901661 ! quinone metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:0044599 +name: AP-5 adaptor complex +namespace: cellular_component +def: "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230] +synonym: "adaptor protein-5 adaptor complex" EXACT [] +is_a: GO:0030119 ! AP-type membrane coat adaptor complex + +[Term] +id: GO:0044600 +name: protein guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins." [GOC:sp, PMID:20651120] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0044601 +name: protein denucleotidylation +namespace: biological_process +def: "The removal of a nucleotide from a protein amino acid." [GOC:sp, PMID:21734656] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0044602 +name: protein deadenylylation +namespace: biological_process +def: "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656] +synonym: "protein deAMPylation" EXACT [PMID:21734656] +is_a: GO:0044601 ! protein denucleotidylation + +[Term] +id: GO:0044603 +name: protein adenylylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656] +synonym: "protein deAMPylase activity" EXACT [PMID:21734656] +synonym: "protein deAMPylation activity" EXACT [PMID:21734656] +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0044604 +name: ABC-type phytochelatin transporter activity +namespace: molecular_function +alt_id: GO:0071991 +alt_id: GO:0071992 +def: "Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, PMID:1396551] +synonym: "ABC-type phytochelatin transmembrane transporter activity" EXACT [] +synonym: "ATP-dependent phytochelatin transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled phytochelatin transmembrane transporter activity" RELATED [] +synonym: "cadystin transmembrane transporter activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "cadystin transmembrane transporter ATPase activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "cadystin transporter activity" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "phytochelatin transmembrane transporter activity" RELATED [] +synonym: "phytochelatin transmembrane transporter ATPase activity" RELATED [] +synonym: "phytochelatin transporter activity" RELATED [] +is_a: GO:0015440 ! ABC-type peptide transporter activity + +[Term] +id: GO:0044605 +name: phosphocholine transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate." [GOC:sp, PMID:21822290] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0044606 +name: phosphocholine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate." [GOC:sp, PMID:22158903] +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0044607 +name: obsolete disruption by symbiont of host endothelial cells +namespace: biological_process +def: "OBSOLETE. Any process in which an organism has a negative effect on the functioning of the host's endothelial cells." [GOC:jl] +comment: This term was obsoleted because the cell type should be captured as an annotation extension. +is_obsolete: true + +[Term] +id: GO:0044608 +name: peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine +namespace: biological_process +def: "The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester." [RESID:AA0507] +synonym: "peptidyl-threonine esterification" EXACT [] +xref: RESID:AA0507 +is_a: GO:0006481 ! C-terminal protein methylation +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0044609 +name: DBIRD complex +namespace: cellular_component +def: "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD." [GOC:sp, PMID:22446626] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0044610 +name: FMN transmembrane transporter activity +namespace: molecular_function +def: "Enables the directed movement of flavine mononucleotide (FMN) from one side of a membrane to the other." [GOC:ans, PMID:22185573] +synonym: "flavine mononucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015215 ! nucleotide transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0044611 +name: nuclear pore inner ring +namespace: cellular_component +def: "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "Nup170 complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0044612 +name: nuclear pore linkers +namespace: cellular_component +def: "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "Nic96 complex" RELATED [] +synonym: "Nup82 complex" RELATED [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0044613 +name: nuclear pore central transport channel +namespace: cellular_component +def: "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "karyopherin docking complex" RELATED [] +synonym: "nuclear pore central channel" EXACT [] +synonym: "nuclear pore central plug" EXACT [] +synonym: "nuclear pore transport channel" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0044614 +name: nuclear pore cytoplasmic filaments +namespace: cellular_component +def: "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "cytoplasmic fibers of the NPC" EXACT [PMID:7775481, PMID:8978815, PMID:9456312] +synonym: "cytoplasmic fibers of the nuclear pore complex" EXACT [PMID:7775481, PMID:8978815, PMID:9456312] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0044615 +name: nuclear pore nuclear basket +namespace: cellular_component +def: "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0044616 +name: modulation of relaxation of muscle in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the relaxation of muscle in a second organism." [GOC:jl] +synonym: "modulation of relaxation of muscle in other organism" EXACT [] +synonym: "regulation of relaxation of muscle in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism +is_a: GO:1901077 ! regulation of relaxation of muscle + +[Term] +id: GO:0044617 +name: modulation of relaxation of smooth muscle in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism." [GOC:jl] +synonym: "modulation of relaxation of smooth muscle in other organism" EXACT [] +synonym: "regulation of relaxation of smooth muscle in other organism" EXACT [] +is_a: GO:0044616 ! modulation of relaxation of muscle in another organism +is_a: GO:1901080 ! regulation of relaxation of smooth muscle + +[Term] +id: GO:0044618 +name: modulation of relaxation of uterine smooth muscle in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl] +synonym: "modulation of relaxation of uterine smooth muscle in other organism" EXACT [] +synonym: "regulation of relaxation of uterine smooth muscle in other organism" EXACT [] +is_a: GO:0044617 ! modulation of relaxation of smooth muscle in another organism +is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation + +[Term] +id: GO:0044619 +name: positive regulation of relaxation of uterine smooth muscle in another organism +namespace: biological_process +def: "The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism." [GOC:jl] +synonym: "positive regulation of relaxation of uterine smooth muscle in other organism" EXACT [] +is_a: GO:0044618 ! modulation of relaxation of uterine smooth muscle in another organism +is_a: GO:1900721 ! positive regulation of uterine smooth muscle relaxation + +[Term] +id: GO:0044620 +name: ACP phosphopantetheine attachment site binding +namespace: molecular_function +def: "Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)." [GOC:jl, GOC:vw] +is_a: GO:0051192 ! prosthetic group binding + +[Term] +id: GO:0044621 +name: modulation of cell migration in another organism +namespace: biological_process +def: "The process in which an organism effects a change in the process of cell migration in a second organism." [GOC:jl] +synonym: "modulation of cell migration in other organism" EXACT [] +synonym: "regulation of cell migration in other organism" EXACT [] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0044622 +name: negative regulation of cell migration in another organism +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." [GOC:jl] +synonym: "negative regulation of cell migration in other organism" EXACT [] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0044621 ! modulation of cell migration in another organism + +[Term] +id: GO:0044623 +name: positive regulation of cell migration in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell migration in a second organism." [GOC:jl] +synonym: "positive regulation of cell migration in other organism" EXACT [] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0044621 ! modulation of cell migration in another organism + +[Term] +id: GO:0044624 +name: envenomation resulting in modulation of cell migration in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] +synonym: "envenomation resulting in modulation of cell migration in other organism" EXACT [] +synonym: "envenomation resulting in regulation of cell migration in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044625 +name: envenomation resulting in negative regulation of cell migration in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] +synonym: "envenomation resulting in negative regulation of cell migration in other organism" EXACT [] +is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in another organism + +[Term] +id: GO:0044626 +name: envenomation resulting in positive regulation of cell migration in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752] +synonym: "envenomation resulting in positive regulation of cell migration in other organism" EXACT [] +is_a: GO:0044624 ! envenomation resulting in modulation of cell migration in another organism + +[Term] +id: GO:0044627 +name: modulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040] +synonym: "modulation of complement activation, classical pathway in other organism" EXACT [] +synonym: "regulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0030450 ! regulation of complement activation, classical pathway +is_a: GO:0044645 ! modulation of complement activation in another organism + +[Term] +id: GO:0044628 +name: positive regulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "positive regulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0044627 ! modulation of complement activation, classical pathway in another organism +is_a: GO:0045960 ! positive regulation of complement activation, classical pathway + +[Term] +id: GO:0044629 +name: negative regulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "negative regulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0044627 ! modulation of complement activation, classical pathway in another organism +is_a: GO:0045959 ! negative regulation of complement activation, classical pathway + +[Term] +id: GO:0044630 +name: modulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040] +synonym: "modulation of complement activation, lectin pathway in other organism" EXACT [] +synonym: "regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0001868 ! regulation of complement activation, lectin pathway +is_a: GO:0044645 ! modulation of complement activation in another organism + +[Term] +id: GO:0044631 +name: positive regulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "positive regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0001870 ! positive regulation of complement activation, lectin pathway +is_a: GO:0044630 ! modulation of complement activation, lectin pathway in another organism + +[Term] +id: GO:0044632 +name: negative regulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "negative regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0001869 ! negative regulation of complement activation, lectin pathway +is_a: GO:0044630 ! modulation of complement activation, lectin pathway in another organism + +[Term] +id: GO:0044633 +name: modulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "modulation of complement activation, alternative pathway in other organism" EXACT [] +synonym: "regulation of complement activation, alternative pathway in other organism" RELATED [] +is_a: GO:0030451 ! regulation of complement activation, alternative pathway +is_a: GO:0044645 ! modulation of complement activation in another organism + +[Term] +id: GO:0044634 +name: negative regulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "negative regulation of complement activation, alternative pathway in other organism" EXACT [] +is_a: GO:0044633 ! modulation of complement activation, alternative pathway in another organism +is_a: GO:0045957 ! negative regulation of complement activation, alternative pathway + +[Term] +id: GO:0044635 +name: positive regulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040] +synonym: "positive regulation of complement activation, alternative pathway in other organism" EXACT [] +is_a: GO:0044633 ! modulation of complement activation, alternative pathway in another organism +is_a: GO:0045958 ! positive regulation of complement activation, alternative pathway + +[Term] +id: GO:0044636 +name: envenomation resulting in modulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in modulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in another organism + +[Term] +id: GO:0044637 +name: envenomation resulting in negative regulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in negative regulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in another organism + +[Term] +id: GO:0044638 +name: envenomation resulting in positive regulation of complement activation, classical pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in positive regulation of complement activation, classical pathway in other organism" EXACT [] +is_a: GO:0044636 ! envenomation resulting in modulation of complement activation, classical pathway in another organism + +[Term] +id: GO:0044639 +name: envenomation resulting in modulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in modulation of complement activation, lectin pathway in other organism" EXACT [] +synonym: "envenomation resulting in regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in another organism + +[Term] +id: GO:0044640 +name: envenomation resulting in negative regulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in negative regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in another organism + +[Term] +id: GO:0044641 +name: envenomation resulting in positive regulation of complement activation, lectin pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in positive regulation of complement activation, lectin pathway in other organism" EXACT [] +is_a: GO:0044639 ! envenomation resulting in modulation of complement activation, lectin pathway in another organism + +[Term] +id: GO:0044642 +name: envenomation resulting in modulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in modulation of complement activation, alternative pathway in other organism" EXACT [] +synonym: "envenomation resulting in regulation of complement activation, alternative pathway in other organism" EXACT [] +is_a: GO:0044646 ! envenomation resulting in modulation of complement activation in another organism + +[Term] +id: GO:0044643 +name: envenomation resulting in positive regulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in positive regulation of complement activation, alternative pathway in other organism" EXACT [] +is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in another organism + +[Term] +id: GO:0044644 +name: envenomation resulting in negative regulation of complement activation, alternative pathway in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in negative regulation of complement activation, alternative pathway in other organism" EXACT [] +is_a: GO:0044642 ! envenomation resulting in modulation of complement activation, alternative pathway in another organism + +[Term] +id: GO:0044645 +name: modulation of complement activation in another organism +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of complement activation in a different organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "modulation of complement activation in other organism" EXACT [] +synonym: "regulation of complement activation in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism +is_a: GO:0045088 ! regulation of innate immune response + +[Term] +id: GO:0044646 +name: envenomation resulting in modulation of complement activation in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040] +synonym: "envenomation resulting in modulation of complement activation in other organism" EXACT [] +synonym: "envenomation resulting in regulation of complement activation in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044647 +name: host-symbiont bicellular tight junction +namespace: cellular_component +def: "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane." [GOC:jl, PMID:21803641] +synonym: "host-parasite tight junction" EXACT [] +synonym: "host-pathogen tight junction" EXACT [] +is_a: GO:0005923 ! bicellular tight junction + +[Term] +id: GO:0044648 +name: histone H3-K4 dimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999] +is_a: GO:0018027 ! peptidyl-lysine dimethylation +is_a: GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0044649 +name: envenomation resulting in cytolysis in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism." [GOC:fj, GOC:jl, PMID:22484288] +synonym: "envenomation resulting in cytolysis in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044650 +name: adhesion of symbiont to host cell +namespace: biological_process +def: "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl] +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0044651 +name: adhesion of symbiont to host epithelial cell +namespace: biological_process +def: "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176] +is_a: GO:0044650 ! adhesion of symbiont to host cell + +[Term] +id: GO:0044652 +name: adhesion of symbiont to host endothelial cell +namespace: biological_process +def: "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176] +is_a: GO:0044650 ! adhesion of symbiont to host cell + +[Term] +id: GO:0044653 +name: dextrin alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: dextrin + H2O = alpha-D-glucose." [PMID:18556189] +xref: EC:3.2.1.- +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0044654 +name: starch alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: starch + H2O = alpha-D-glucose." [PMID:18556189] +xref: EC:3.2.1.- +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0044655 +name: phagosome reneutralization +namespace: biological_process +def: "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation." [GOC:rjd, PMID:22008230] +synonym: "phagosomal reneutralization" EXACT [] +synonym: "phagosome pH elevation" EXACT [] +is_a: GO:0051454 ! intracellular pH elevation +relationship: part_of GO:0090382 ! phagosome maturation + +[Term] +id: GO:0044656 +name: regulation of post-lysosomal vacuole size +namespace: biological_process +def: "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:rjd, PMID:22008230] +synonym: "regulation of post-lysosome size" EXACT [GOC:dph] +synonym: "regulation of postlysosomal vacuole size" EXACT [] +synonym: "regulation of postlysosome vacuole size" EXACT [] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0044657 +name: obsolete pore formation in membrane of other organism during symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction." [GOC:jl] +comment: This term was obsoleted because it represents an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0044658 +name: pore formation in membrane of host by symbiont +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism." [GOC:jl] +is_a: GO:0052111 ! modification by symbiont of host structure + +[Term] +id: GO:0044659 +name: viral release from host cell by cytolysis +namespace: biological_process +alt_id: GO:0019077 +alt_id: GO:0046756 +def: "The killing by a virus of a cell by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl, PMID:26728778] +synonym: "cytolysis by virus of host cell" RELATED [] +synonym: "lytic viral life cycle" RELATED [] +synonym: "lytic viral release" EXACT [] +synonym: "viral exit from host cell by cytolysis" EXACT [] +synonym: "viral release by cell lysis" EXACT [] +synonym: "viral release by host cell lysis" EXACT [] +xref: VZ:1077 "Cell lysis" +is_a: GO:0019076 ! viral release from host cell +is_a: GO:0039633 ! killing by virus of host cell + +[Term] +id: GO:0044660 +name: viral release by cytolysis via pore formation in host cell membrane +namespace: biological_process +def: "The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane." [GOC:jl] +synonym: "cytolysis by virus via pore formation in host cell membrane" RELATED [] +synonym: "viral exit by cytolysis via pore formation in host cell membrane" EXACT [] +is_a: GO:0044659 ! viral release from host cell by cytolysis + +[Term] +id: GO:0044662 +name: disruption by virus of host cell membrane +namespace: biological_process +def: "A process by which a virus has a negative effect on the functioning of a host cellular membrane." [GOC:jl] +synonym: "disruption by organism of host cell membrane" EXACT [] +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0051673 ! membrane disruption in another organism +is_a: GO:0052025 ! modification by symbiont of host cell membrane + +[Term] +id: GO:0044663 +name: establishment or maintenance of cell type involved in phenotypic switching +namespace: biological_process +def: "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0036166 ! phenotypic switching + +[Term] +id: GO:0044664 +name: obsolete reversion of cell type to default state involved in phenotypic switching +namespace: biological_process +def: "OBSOLETE. The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl] +comment: This term was made obsolete because it is ambiguous. +is_obsolete: true + +[Term] +id: GO:0044665 +name: MLL1/2 complex +namespace: cellular_component +def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999] +synonym: "Trx-containing complex" EXACT [] +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0044666 +name: MLL3/4 complex +namespace: cellular_component +def: "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999] +synonym: "Trr/COMPASS-like complex" EXACT [] +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0044667 +name: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)." [GOC:crds] +synonym: "(R)-carnitine:gamma-butyrobetaine antiporter activity" EXACT [] +synonym: "L-carnitine:4-(trimethylammonio)butanoate antiporter activity" EXACT [] +synonym: "L-carnitine:gamma-butyrobetaine antiporter activity" EXACT [] +xref: RHEA:29427 +is_a: GO:0015491 ! cation:cation antiporter activity +is_a: GO:1901235 ! (R)-carnitine transmembrane transporter activity +is_a: GO:1901236 ! 4-(trimethylammonio)butanoate transmembrane transporter activity + +[Term] +id: GO:0044668 +name: sodium:malonate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)." [GOC:crds] +xref: RHEA:33135 +is_a: GO:0017153 ! sodium:dicarboxylate symporter activity +is_a: GO:1901239 ! malonate(1-) transmembrane transporter activity + +[Term] +id: GO:0044669 +name: sodium:galactoside symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)." [GOC:crds] +is_a: GO:0015370 ! solute:sodium symporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0044671 +name: sorocarp spore cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass)." [GOC:jl, GOC:rjd] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048837 ! sorocarp sorus development + +[Term] +id: GO:0044672 +name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex +namespace: cellular_component +def: "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis." [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306] +synonym: "carbon monoxide dehydrogenase" BROAD [] +synonym: "carbon-monoxide:(acceptor) oxidoreductase complex" BROAD [] +synonym: "CO dehydrogenase complex" BROAD [] +synonym: "CO dehydrogenase/acetyl-CoA synthase complex" EXACT [] +synonym: "CODH" BROAD [] +synonym: "CODH/ACS complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044673 +name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex +namespace: cellular_component +def: "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420." [GOC:mengo_curators, PMID:14593448] +synonym: "FO-synthase complex" EXACT [] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0044674 +name: methyl coenzyme M reductase complex +namespace: cellular_component +def: "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis." [GOC:mengo_curators, PMID:9367957] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0044675 +name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex +namespace: cellular_component +def: "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:8125106, PMID:8575452] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044676 +name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex +namespace: cellular_component +def: "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:1915887, PMID:8954165] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044677 +name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex +namespace: cellular_component +def: "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis." [GOC:mengo_curators, PMID:8477726] +synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex" EXACT [] +synonym: "coenzyme M methyltransferase complex" BROAD [] +synonym: "methyl-H4MPT" BROAD [] +synonym: "N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044678 +name: CoB-CoM heterodisulfide reductase complex +namespace: cellular_component +def: "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine." [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468] +synonym: "coenzyme M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase complex" EXACT [] +synonym: "hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide oxidoreductase complex" EXACT [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0044679 +name: methanophenazine reducing hydrogenase complex +namespace: cellular_component +def: "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides." [GOC:mengo_curators, PMID:9555882] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0044680 +name: methylthiol:coenzyme M methyltransferase complex +namespace: cellular_component +def: "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis." [GOC:mengo_curators, PMID:11073950, PMID:9371433] +synonym: "methylthiol coenzyme M methyl transferase complex" EXACT [] +synonym: "methylthiol:coenzyme M methyl transferase complex" EXACT [] +synonym: "methylthiol:CoM methyltransferase complex" EXACT [] +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0044681 +name: sulfopyruvate decarboxylase complex +namespace: cellular_component +def: "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis." [GOC:mengo_curators, PMID:10940029] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0044682 +name: archaeal-specific GTP cyclohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+." [GOC:mengo_curators, PMID:17497938] +synonym: "Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity" EXACT [] +synonym: "MptA activity" NARROW [] +is_a: GO:0003933 ! GTP cyclohydrolase activity + +[Term] +id: GO:0044683 +name: methylthiol:coenzyme M methyltransferase activity +namespace: molecular_function +def: "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM." [MetaCyc:RXN-8125, PMID:9371433] +comment: This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC:2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC:2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation. +synonym: "methylthiol:coenzyme M methyl transferase activity" EXACT [] +xref: EC:2.1.1.251 +xref: MetaCyc:RXN-8125 +xref: RHEA:32667 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0044684 +name: dihydromethanopterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691] +xref: EC:1.5.99.15 +xref: RHEA:42804 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0044685 +name: tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O." [GOC:mengo_curators, PMID:12902326] +xref: EC:2.1.2.- +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0044686 +name: cysteate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-." [GOC:mengo_curators, PMID:19761441] +xref: EC:2.5.1.76 +xref: MetaCyc:RXN-11108 +xref: RHEA:26486 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0044687 +name: geranylfarnesyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate." [GOC:mengo_curators, PMID:20097171] +xref: EC:2.5.1.81 +xref: MetaCyc:RXN-8813 +xref: RHEA:25694 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0044688 +name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+." [GOC:mengo_curators, PMID:19746965] +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0044689 +name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+." [GOC:mengo_curators, PMID:11948155, PMID:14593448] +synonym: "FO synthase" EXACT [] +xref: EC:2.5.1.147 +xref: MetaCyc:RXN-8079 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0044691 +name: tooth eruption +namespace: biological_process +def: "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption] +xref: Wikipedia:Tooth_eruption +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0042476 ! odontogenesis + +[Term] +id: GO:0044692 +name: exoribonuclease activator activity +namespace: molecular_function +def: "Binds to and increases the activity of an exoribonuclease." [GOC:rb, PMID:22570495] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0044693 +name: trehalose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)." [PMID:11136464] +synonym: "trehalose:hydrogen symporter activity" EXACT [] +is_a: GO:0005351 ! carbohydrate:proton symporter activity +is_a: GO:0015574 ! trehalose transmembrane transporter activity + +[Term] +id: GO:0044694 +name: pore-mediated entry of viral genome into host cell +namespace: biological_process +def: "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, UniProtKB-KW:KW-1172, VZ:979] +comment: This mechanism is used by animal viruses such as poliovirus. Various tailed bacteriophages also carry specialized proteins which open a pore or a channel in the host membrane(s) to allow genome delivery into host cytoplasm. +synonym: "membrane puncture-mediated penetration of viral genome into host cell" RELATED [UniProtKB-KW:KW-1172] +synonym: "pore-mediated penetration of viral genome into host cell" EXACT [] +synonym: "viral entry via genome injection" EXACT [] +synonym: "viral genome delivery via icosahedral vertex" NARROW [] +synonym: "viral genome translocation" EXACT [] +synonym: "viral pore-forming protein" RELATED [GOC:bf] +xref: VZ:979 "Pore-mediated penetration of viral genome into host cell" +is_a: GO:0046718 ! viral entry into host cell +is_a: GO:0046794 ! transport of virus + +[Term] +id: GO:0044695 +name: Dsc E3 ubiquitin ligase complex +namespace: cellular_component +def: "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism." [GOC:mah, GOC:vw, PMID:21504829] +is_a: GO:0000151 ! ubiquitin ligase complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0031090 ! organelle membrane + +[Term] +id: GO:0044696 +name: killing by virus of host cell by post-segregational killing +namespace: biological_process +def: "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes." [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system] +comment: Note that this process occurs after the cell division partitioning event. +synonym: "killing by virus of host cell by PSK" EXACT [] +synonym: "killing by virus of host cell by toxin-antitoxin system" EXACT [] +is_a: GO:0039633 ! killing by virus of host cell + +[Term] +id: GO:0044697 +name: HICS complex +namespace: cellular_component +def: "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins." [PMID:22623719] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044698 +name: obsolete morphogenesis of symbiont in host cell +namespace: biological_process +def: "OBSOLETE. The process in which a symbiont undergoes a change in shape or form, within the host's cell." [GOC:jl] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0044701 +name: obsolete response to stimulus by single organism +namespace: biological_process +def: "OBSOLETE. A response to a stimulus that involves only one organism." [GOC:jl] +comment: This term was made obsolete because we decided that all responses are single-organism. +synonym: "response to stimulus by single organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0044703 +name: multi-organism reproductive process +namespace: biological_process +def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] +subset: goslim_drosophila +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0044706 +name: multi-multicellular organism process +namespace: biological_process +def: "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0044715 +name: 8-oxo-dGDP phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate." [GOC:pde, PMID:22556419, RHEA:32063] +xref: EC:3.6.1.58 +xref: Reactome:R-HSA-2395873 "NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP" +xref: Reactome:R-HSA-2395879 "NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP" +xref: RHEA:32063 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0044716 +name: 8-oxo-GDP phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." [GOC:pde, PMID:22556419, RHEA:62356] +xref: EC:3.6.1.58 +xref: RHEA:62356 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0044717 +name: 8-hydroxy-dADP phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate." [GOC:pde, PMID:22556419] +xref: Reactome:R-HSA-2395965 "NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP" +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0044718 +name: siderophore transmembrane transport +namespace: biological_process +def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "siderophore membrane transport" EXACT [] +is_a: GO:0015891 ! siderophore transport +is_a: GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0044719 +name: regulation of imaginal disc-derived wing size +namespace: biological_process +def: "Any process that modulates the size of an imaginal disc-derived wing." [PMID:21393605] +is_a: GO:0090066 ! regulation of anatomical structure size +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0044720 +name: negative regulation of imaginal disc-derived wing size +namespace: biological_process +def: "Any process that reduces the size of an imaginal disc-derived wing." [PMID:21393605] +is_a: GO:0044719 ! regulation of imaginal disc-derived wing size + +[Term] +id: GO:0044721 +name: protein import into peroxisome matrix, substrate release +namespace: biological_process +def: "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane." [PMID:21976670] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0016558 ! protein import into peroxisome matrix + +[Term] +id: GO:0044722 +name: renal phosphate excretion +namespace: biological_process +def: "The elimination of phosphate ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:jl, PMID:25287933] +synonym: "renal phosphate ion excretion" EXACT [] +is_a: GO:0097254 ! renal tubular secretion + +[Term] +id: GO:0044725 +name: chromatin reprogramming in the zygote +namespace: biological_process +def: "The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process." [GOC:sp, PMID:22868271] +is_a: GO:0043045 ! DNA methylation involved in embryo development + +[Term] +id: GO:0044726 +name: protection of DNA demethylation of female pronucleus +namespace: biological_process +def: "The protection of the maternal genome from DNA demethylation in the zygote following fertilization." [GOC:sp, PMID:22868271] +is_a: GO:0044030 ! regulation of DNA methylation +relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote + +[Term] +id: GO:0044727 +name: DNA demethylation of male pronucleus +namespace: biological_process +def: "The active DNA demethylation of the paternal genome that takes place before the first cell division." [GOC:sp, PMID:22868271] +is_a: GO:0043045 ! DNA methylation involved in embryo development +relationship: part_of GO:0044725 ! chromatin reprogramming in the zygote + +[Term] +id: GO:0044728 +name: DNA methylation or demethylation +namespace: biological_process +def: "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl] +synonym: "changes in DNA methylation" RELATED [] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0044729 +name: hemi-methylated DNA-binding +namespace: molecular_function +def: "Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, GOC:sp, PMID:18772889] +synonym: "double-stranded hemi-methylated DNA binding" EXACT [] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0044730 +name: bone sialoprotein binding +namespace: molecular_function +def: "Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin." [PMID:10642520] +synonym: "bone sialoprotein II binding" EXACT [] +xref: InterPro:IPR008412 +is_a: GO:0005515 ! protein binding +is_a: GO:0050840 ! extracellular matrix binding + +[Term] +id: GO:0044731 +name: Ost-alpha/Ost-beta complex +namespace: cellular_component +def: "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity." [PMID:17650074, PMID:22535958] +synonym: "(Ost)2 complex" RELATED [] +synonym: "Ost alpha-Ost beta complex" EXACT [] +synonym: "SLC51 complex" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0044732 +name: mitotic spindle pole body +namespace: cellular_component +def: "The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome." [GOC:mah, GOC:vw] +is_a: GO:0005816 ! spindle pole body + +[Term] +id: GO:0044733 +name: envenomation resulting in modulation of acid-sensing ion channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] +synonym: "envenomation resulting in modulation of acid-sensing ion channel activity in other organism" EXACT [] +synonym: "envenomation resulting in modulation of ASIC channel activity in other organism" EXACT [] +is_a: GO:0044560 ! envenomation resulting in modulation of ion channel activity in another organism + +[Term] +id: GO:0044734 +name: envenomation resulting in positive regulation of acid-sensing ion channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] +synonym: "envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism" EXACT [] +synonym: "envenomation resulting in positive regulation of ASIC channel activity in other organism" EXACT [] +is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in another organism + +[Term] +id: GO:0044735 +name: envenomation resulting in negative regulation of acid-sensing ion channel activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] +synonym: "envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism" EXACT [] +synonym: "envenomation resulting in negative regulation of ASIC channel activity in other organism" EXACT [] +is_a: GO:0044733 ! envenomation resulting in modulation of acid-sensing ion channel activity in another organism + +[Term] +id: GO:0044736 +name: acid-sensing ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex." [GOC:jl] +synonym: "ASIC activity" EXACT [] +xref: Reactome:R-HSA-2671885 "ASIC trimers:H+ transport extracellular Na+ to cytosol" +xref: Wikipedia:Acid-sensing_ion_channel +is_a: GO:0015280 ! ligand-gated sodium channel activity + +[Term] +id: GO:0044737 +name: modulation of acid-sensing ion channel in another organism +namespace: biological_process +def: "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism." [GOC:jl] +synonym: "modulation of acid-sensing ion channel in other organism" EXACT [] +synonym: "regulation of acid-sensing ion channel in other organism" EXACT [] +synonym: "regulation of ASIC channel in other organism" EXACT [] +is_a: GO:0044561 ! modulation of ion channel activity in another organism + +[Term] +id: GO:0044738 +name: negative regulation of acid-sensing ion channel in another organism +namespace: biological_process +def: "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl] +synonym: "negative regulation of acid-sensing ion channel in other organism" EXACT [] +synonym: "negative regulation of ASIC channel in other organism" EXACT [] +is_a: GO:0044737 ! modulation of acid-sensing ion channel in another organism + +[Term] +id: GO:0044739 +name: positive regulation of acid-sensing ion channel in another organism +namespace: biological_process +def: "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl] +synonym: "positive regulation of acid-sensing ion channel in other organism" EXACT [] +synonym: "positive regulation of ASIC channel in other organism" EXACT [] +is_a: GO:0044737 ! modulation of acid-sensing ion channel in another organism + +[Term] +id: GO:0044740 +name: negative regulation of sensory perception of pain in another organism +namespace: biological_process +def: "A process that negatively regulates the sensory perception of pain in a different organism." [GOC:fj, GOC:jl] +synonym: "inhibition of sensory perception of pain in another organism" EXACT [] +synonym: "negative regulation of sensory perception of pain in other organism" EXACT [] +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:0044465 ! modulation of sensory perception of pain in another organism + +[Term] +id: GO:0044741 +name: envenomation resulting in negative regulation of sensory perception of pain in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] +synonym: "envenomation resulting in inhibition of sensory perception of pain in other organism" EXACT [] +synonym: "envenomation resulting in negative regulation of sensory perception of pain in other organism" EXACT [] +is_a: GO:0044742 ! envenomation resulting in modulation of sensory perception of pain in another organism + +[Term] +id: GO:0044742 +name: envenomation resulting in modulation of sensory perception of pain in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652] +synonym: "envenomation resulting in modulation of sensory perception of pain in other organism" EXACT [] +synonym: "envenomation resulting in regulation of sensory perception of pain in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0044743 +name: protein transmembrane import into intracellular organelle +namespace: biological_process +def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl] +is_a: GO:0017038 ! protein import +is_a: GO:0071806 ! protein transmembrane transport +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0044747 +name: mature miRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293] +synonym: "miRNA 3' end terminal trimming" BROAD [] +synonym: "miRNA 3'-end processing" BROAD [] +synonym: "miRNA trimming" BROAD [] +is_a: GO:0010586 ! miRNA metabolic process +is_a: GO:0043628 ! ncRNA 3'-end processing +relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:0044748 +name: 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart] +synonym: "exonucleolytic trimming to generate 3' end of miRNA" BROAD [] +is_a: GO:0000175 ! 3'-5'-exoribonuclease activity + +[Term] +id: GO:0044750 +name: high-affinity nickel cation transmembrane transporter activity +namespace: molecular_function +def: "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl] +is_a: GO:0015099 ! nickel cation transmembrane transporter activity + +[Term] +id: GO:0044751 +name: cellular response to human chorionic gonadotropin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635] +synonym: "cellular response to human chorionic gonadotrophin stimulus" EXACT [GOC:dph] +is_a: GO:0044752 ! response to human chorionic gonadotropin +is_a: GO:0071371 ! cellular response to gonadotropin stimulus + +[Term] +id: GO:0044752 +name: response to human chorionic gonadotropin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635] +synonym: "response to human chorionic gonadotropin stimulus" EXACT [GOC:dos] +is_a: GO:0034698 ! response to gonadotropin + +[Term] +id: GO:0044753 +name: amphisome +namespace: cellular_component +def: "Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327] +is_a: GO:0005776 ! autophagosome + +[Term] +id: GO:0044754 +name: autolysosome +namespace: cellular_component +def: "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921] +synonym: "autophagolysosome" EXACT [] +synonym: "AVd" EXACT [] +synonym: "degrading autophagic vacuole" EXACT [] +xref: NIF_Subcellular:sao8444068431 +is_a: GO:0005767 ! secondary lysosome +is_a: GO:0005776 ! autophagosome + +[Term] +id: GO:0044758 +name: modulation by symbiont of host synaptic transmission +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl] +synonym: "regulation by symbiont of host synaptic transmission" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0044759 +name: negative regulation by symbiont of host synaptic transmission +namespace: biological_process +def: "Any process in which a symbiont organism decreases the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl] +is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission +is_a: GO:0050805 ! negative regulation of synaptic transmission + +[Term] +id: GO:0044760 +name: modulation by symbiont of host cholinergic synaptic transmission +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl] +synonym: "regulation by symbiont of host cholinergic synaptic transmission" EXACT [] +is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic +is_a: GO:0044758 ! modulation by symbiont of host synaptic transmission + +[Term] +id: GO:0044761 +name: negative regulation by symbiont of host cholinergic synaptic transmission +namespace: biological_process +def: "Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl] +is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic +is_a: GO:0044759 ! negative regulation by symbiont of host synaptic transmission +is_a: GO:0044760 ! modulation by symbiont of host cholinergic synaptic transmission + +[Term] +id: GO:0044762 +name: negative regulation by symbiont of host neurotransmitter secretion +namespace: biological_process +def: "Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism." [GOC:jl] +is_a: GO:0044079 ! modulation by symbiont of host neurotransmitter secretion +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion + +[Term] +id: GO:0044764 +name: multi-organism cellular process +namespace: biological_process +def: "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0044766 +name: obsolete multi-organism transport +namespace: biological_process +def: "OBSOLETE. The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0044768 +name: NMS complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an NMS complex. The NMS complex results from the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) and is required for kinetochore assembly." [GOC:vw, PMID:22561345] +synonym: "KMN complex interaction involved in chromosome segregation" EXACT [] +synonym: "KMN kinetochore network assembly" EXACT [] +synonym: "KMN kinetochore network formation" EXACT [] +synonym: "KMN network assembly involved in chromosome segregation" EXACT [] +synonym: "KNL-1-Mis12-Ndc80 assembly" EXACT [] +synonym: "KNL-1-Mis12-Ndc80 formation" EXACT [] +synonym: "Ndc80-MIND-Spc7 complex assembly" EXACT [] +synonym: "Ndc80-MIND-Spc7 complex formation" EXACT [] +synonym: "NMS complex assembly involved in kinetochore assembly" EXACT [] +synonym: "NMS complex association involved in chromosome segregation" EXACT [] +synonym: "NMS complex formation" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0051382 ! kinetochore assembly + +[Term] +id: GO:0044769 +name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism +namespace: molecular_function +def: "Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl] +is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity + +[Term] +id: GO:0044770 +name: cell cycle phase transition +namespace: biological_process +def: "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] +synonym: "cell cycle transition" EXACT [] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0044771 +name: meiotic cell cycle phase transition +namespace: biological_process +def: "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle] +synonym: "cell cycle transition" BROAD [] +is_a: GO:0044770 ! cell cycle phase transition +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0044772 +name: mitotic cell cycle phase transition +namespace: biological_process +def: "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] +subset: goslim_pombe +is_a: GO:0044770 ! cell cycle phase transition +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0044773 +name: mitotic DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:1902402 +def: "A signal transduction process involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] +synonym: "mitotic DNA damage checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic DNA damage checkpoint" EXACT [] +is_a: GO:0000077 ! DNA damage checkpoint signaling +is_a: GO:0044774 ! mitotic DNA integrity checkpoint signaling + +[Term] +id: GO:0044774 +name: mitotic DNA integrity checkpoint signaling +namespace: biological_process +alt_id: GO:0070683 +alt_id: GO:1902403 +def: "A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] +synonym: "intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction involved in topo II checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in topo II checkpoint" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in topoisomerase II checkpoint" NARROW [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in topo II checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in mitotic DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in topo II checkpoint" NARROW [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in topoisomerase II checkpoint" RELATED [GOC:TermGenie] +synonym: "mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [] +synonym: "mitotic DNA integrity checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic DNA integrity checkpoint" EXACT [] +synonym: "signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in topo II checkpoint" RELATED [GOC:TermGenie] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:0031570 ! DNA integrity checkpoint signaling + +[Term] +id: GO:0044775 +name: DNA polymerase III, beta sliding clamp processivity factor complex +namespace: cellular_component +def: "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species." [GOC:jl, UniProt:O73947] +is_a: GO:0044796 ! DNA polymerase processivity factor complex +relationship: part_of GO:0009360 ! DNA polymerase III complex + +[Term] +id: GO:0044776 +name: DNA polymerase III, core complex +namespace: cellular_component +def: "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities." [GOC:jl, UniProt:P06710] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0009360 ! DNA polymerase III complex + +[Term] +id: GO:0044777 +name: single-stranded DNA-binding protein complex +namespace: cellular_component +def: "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair." [GOC:jl, UniProt:P0AGE0] +synonym: "SSB complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0009295 ! nucleoid + +[Term] +id: GO:0044778 +name: meiotic DNA integrity checkpoint signaling +namespace: biological_process +def: "A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] +synonym: "meiotic DNA integrity checkpoint" EXACT [] +is_a: GO:0031570 ! DNA integrity checkpoint signaling +is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling + +[Term] +id: GO:0044779 +name: meiotic spindle checkpoint signaling +namespace: biological_process +alt_id: GO:1902398 +def: "A signal transduction process that contributes to a cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle." [GOC:mtg_cell_cycle] +synonym: "intracellular signal transduction involved in meiotic spindle checkpoint" EXACT [] +synonym: "intracellular signal transduction pathway involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] +synonym: "meiotic spindle checkpoint" EXACT [] +is_a: GO:0031577 ! spindle checkpoint signaling +is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling +is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle + +[Term] +id: GO:0044780 +name: bacterial-type flagellum assembly +namespace: biological_process +def: "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl] +synonym: "bacterial flagellum assembly" EXACT [] +is_a: GO:0030031 ! cell projection assembly +is_a: GO:0044781 ! bacterial-type flagellum organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0044781 +name: bacterial-type flagellum organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl] +is_a: GO:0006996 ! organelle organization +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0044782 +name: cilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +subset: goslim_drosophila +subset: goslim_generic +synonym: "microtubule-based flagellum organization" EXACT [] +is_a: GO:0006996 ! organelle organization +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0044784 +name: metaphase/anaphase transition of cell cycle +namespace: biological_process +def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:0033045 ! regulation of sister chromatid segregation +is_a: GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:0044785 +name: metaphase/anaphase transition of meiotic cell cycle +namespace: biological_process +def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis." [GOC:mtg_cell_cycle] +synonym: "meiotic metaphase/anaphase transition" EXACT [] +is_a: GO:0044771 ! meiotic cell cycle phase transition +is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle + +[Term] +id: GO:0044786 +name: cell cycle DNA replication +namespace: biological_process +def: "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:0006261 ! DNA-dependent DNA replication +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0044787 +name: bacterial-type DNA replication +namespace: biological_process +def: "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome." [GOC:mtg_cell_cycle] +synonym: "bacterial-type cell cycle DNA replication" EXACT [] +is_a: GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:0044788 +name: modulation by host of viral process +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected." [GOC:jl] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0044789 +name: obsolete modulation by host of viral release from host cell +namespace: biological_process +def: "OBSOLETE. A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167] +comment: This term was obsoleted because there is no evidence that it is a regulated process. +is_obsolete: true +replaced_by: GO:0019076 + +[Term] +id: GO:0044790 +name: suppression of viral release by host +namespace: biological_process +alt_id: GO:1902187 +def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167] +synonym: "down regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "down regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "down regulation of viral release" EXACT [GOC:TermGenie] +synonym: "down regulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "down regulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "down-regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral release" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "downregulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "downregulation of viral exit" EXACT [GOC:TermGenie] +synonym: "downregulation of viral release" EXACT [GOC:TermGenie] +synonym: "downregulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "downregulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "inhibition of release of virus from host" EXACT [GOC:TermGenie] +synonym: "inhibition of viral exit" EXACT [GOC:TermGenie] +synonym: "inhibition of viral release" EXACT [GOC:TermGenie] +synonym: "inhibition of viral release from host cell" NARROW [GOC:TermGenie] +synonym: "inhibition of viral shedding" EXACT [GOC:TermGenie] +synonym: "negative regulation by host of viral release from host cell" EXACT [] +synonym: "negative regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral release" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral release from host cell" EXACT [] +synonym: "negative regulation of viral shedding" EXACT [GOC:TermGenie] +is_a: GO:0051607 ! defense response to virus + +[Term] +id: GO:0044791 +name: obsolete positive regulation by host of viral release from host cell +namespace: biological_process +def: "OBSOLETE. A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl] +comment: This term was obsoleted because there is no evidence that it is a regulated process. +is_obsolete: true +replaced_by: GO:0019076 + +[Term] +id: GO:0044793 +name: negative regulation by host of viral process +namespace: biological_process +def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected." [GOC:jl] +is_a: GO:0044788 ! modulation by host of viral process +relationship: negatively_regulates GO:0016032 ! viral process + +[Term] +id: GO:0044794 +name: positive regulation by host of viral process +namespace: biological_process +def: "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl] +is_a: GO:0044788 ! modulation by host of viral process +relationship: positively_regulates GO:0016032 ! viral process + +[Term] +id: GO:0044795 +name: trans-Golgi network to recycling endosome transport +namespace: biological_process +def: "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes." [GOC:lb, PMID:18779367] +is_a: GO:0016197 ! endosomal transport + +[Term] +id: GO:0044796 +name: DNA polymerase processivity factor complex +namespace: cellular_component +def: "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl] +is_a: GO:0150005 ! enzyme activator complex + +[Term] +id: GO:0044799 +name: NarGHI complex +namespace: cellular_component +def: "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit." [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535] +synonym: "cytoplasmic membrane-bound quinol-nitrate oxidoreductase" EXACT [] +synonym: "nitrate reductase A" EXACT [] +is_a: GO:0009325 ! nitrate reductase complex +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:0098803 ! respiratory chain complex +relationship: part_of GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0070470 ! plasma membrane respirasome + +[Term] +id: GO:0044800 +name: obsolete multi-organism membrane fusion +namespace: biological_process +def: "OBSOLETE. The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism." [GOC:jl] +comment: This term was obsoleted because it is not a biologically meaningful grouping class. +is_obsolete: true + +[Term] +id: GO:0044803 +name: multi-organism membrane organization +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism." [GOC:jl] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0044804 +name: autophagy of nucleus +namespace: biological_process +def: "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549] +synonym: "nucleophagy" RELATED [] +synonym: "nucleus degradation" EXACT [] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0044805 +name: late nucleophagy +namespace: biological_process +def: "A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199] +synonym: "LN" EXACT [] +is_a: GO:0044804 ! autophagy of nucleus + +[Term] +id: GO:0044806 +name: G-quadruplex DNA unwinding +namespace: biological_process +def: "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261] +is_a: GO:0032392 ! DNA geometric change + +[Term] +id: GO:0044807 +name: macrophage migration inhibitory factor production +namespace: biological_process +def: "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "MIF production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0044808 +name: oncostatin M production +namespace: biological_process +def: "The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "OSM production" EXACT [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0044809 +name: chemokine (C-C motif) ligand 17 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL17 production" EXACT [] +synonym: "TARC production" EXACT [] +synonym: "thymus and activation regulated chemokine production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0044812 +name: fermentative hydrogen production +namespace: biological_process +def: "The fermentation of organic substances with a net release of hydrogen." [GOC:mengo_curators] +synonym: "carbohydrate fermentation" EXACT [] +xref: Wikipedia:Fermentative_hydrogen_production +is_a: GO:0006113 ! fermentation +is_a: GO:1902422 ! hydrogen biosynthetic process + +[Term] +id: GO:0044813 +name: glycolytic fermentation via PFOR pathway +namespace: biological_process +def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species." [GOC:mengo_curators, PMID:20395274, PMID:20692761] +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0044814 +name: glycolytic fermentation via PFL pathway +namespace: biological_process +def: "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli." [GOC:mengo_curators, PMID:20395274, PMID:20692761] +is_a: GO:0019660 ! glycolytic fermentation + +[Term] +id: GO:0044815 +name: DNA packaging complex +namespace: cellular_component +def: "A protein complex that plays a role in the process of DNA packaging." [GOC:jl] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044816 +name: Nsk1-Dlc1 complex +namespace: cellular_component +def: "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation." [GOC:vw, PMID:22065639] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0044817 +name: hydrogen generation via biophotolysis +namespace: biological_process +def: "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae." [GOC:mengo_curators, PMID:20395274, PMID:20692761] +synonym: "hydrogen biosynthesis via biophotolysis" EXACT [] +is_a: GO:1902422 ! hydrogen biosynthetic process + +[Term] +id: GO:0044818 +name: mitotic G2/M transition checkpoint +namespace: biological_process +def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle + +[Term] +id: GO:0044819 +name: mitotic G1/S transition checkpoint signaling +namespace: biological_process +def: "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] +synonym: "mitotic G1/S transition checkpoint" EXACT [] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle + +[Term] +id: GO:0044820 +name: mitotic telomere tethering at nuclear periphery +namespace: biological_process +def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:25778919] +is_a: GO:0034398 ! telomere tethering at nuclear periphery +relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery + +[Term] +id: GO:0044821 +name: meiotic telomere tethering at nuclear periphery +namespace: biological_process +def: "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:0034398 ! telomere tethering at nuclear periphery +is_a: GO:0045141 ! meiotic telomere clustering + +[Term] +id: GO:0044823 +name: retroviral integrase activity +namespace: molecular_function +def: "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism." [PMID:19091057] +is_a: GO:0008907 ! integrase activity + +[Term] +id: GO:0044824 +name: retroviral 3' processing activity +namespace: molecular_function +def: "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823, Reactome:R-HSA-164522] +comment: This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification. +synonym: "3' processing reaction" EXACT [] +synonym: "3'-processing activity" EXACT [] +is_a: GO:0004520 ! endodeoxyribonuclease activity +relationship: part_of GO:0044823 ! retroviral integrase activity + +[Term] +id: GO:0044825 +name: obsolete retroviral strand transfer activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction." [PMID:22580823] +comment: This term was obsoleted because it represents part of an activity. +synonym: "strand transfer reaction" EXACT [] +is_obsolete: true +consider: GO:0044823 + +[Term] +id: GO:0044826 +name: viral genome integration into host DNA +namespace: biological_process +def: "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses." [PMID:19091057] +synonym: "viral genome integration" EXACT [] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0044827 +name: modulation by host of viral genome replication +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl] +synonym: "regulation by host of viral genome reproduction" EXACT [] +is_a: GO:0044788 ! modulation by host of viral process +relationship: regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0044828 +name: negative regulation by host of viral genome replication +namespace: biological_process +def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:jl] +is_a: GO:0044793 ! negative regulation by host of viral process +is_a: GO:0044827 ! modulation by host of viral genome replication +relationship: negatively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0044829 +name: positive regulation by host of viral genome replication +namespace: biological_process +def: "A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication." [GOC:jl] +is_a: GO:0044794 ! positive regulation by host of viral process +is_a: GO:0044827 ! modulation by host of viral genome replication +relationship: positively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0044830 +name: modulation by host of viral RNA genome replication +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication." [GOC:jl] +synonym: "regulation by host of viral RNA genome replication" EXACT [] +is_a: GO:0044827 ! modulation by host of viral genome replication +relationship: regulates GO:0039694 ! viral RNA genome replication + +[Term] +id: GO:0044831 +name: modulation by virus of host cytokine production +namespace: biological_process +def: "Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism." [GOC:jl] +is_a: GO:0039656 ! modulation by virus of host gene expression +is_a: GO:0075528 ! modulation by virus of host immune response +relationship: regulates GO:0001816 ! cytokine production + +[Term] +id: GO:0044832 +name: induction by virus of host cytokine production +namespace: biological_process +def: "The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism." [GOC:jl] +synonym: "positive regulation by virus of host cytokine production" EXACT [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0044831 ! modulation by virus of host cytokine production +is_a: GO:0050776 ! regulation of immune response +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0044833 +name: modulation by virus of host protein transport +namespace: biological_process +def: "Any viral process that modulates the frequency, rate or extent of protein transport in its host organism." [GOC:jl, PMID:22334672] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0052038 ! modulation by symbiont of host intracellular transport +relationship: regulates GO:0015031 ! protein transport + +[Term] +id: GO:0044834 +name: retroviral intasome +namespace: cellular_component +def: "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome." [PMID:20118915] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0044835 +name: hydrogen generation via nitrogenase +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria." [GOC:mengo_curators, PMID:22128188] +is_a: GO:1902422 ! hydrogen biosynthetic process + +[Term] +id: GO:0044836 +name: D-xylose fermentation +namespace: biological_process +def: "The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP." [GOC:mengo_curators] +is_a: GO:0006113 ! fermentation +is_a: GO:0044577 ! xylose catabolic process to ethanol + +[Term] +id: GO:0044837 +name: actomyosin contractile ring organization +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle] +synonym: "cytokinesis, actomyosin contractile ring organization" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0030866 ! cortical actin cytoskeleton organization +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis + +[Term] +id: GO:0044838 +name: cell quiescence +namespace: biological_process +def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah] +comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "cell cycle quiescence" RELATED [GOC:mah] +synonym: "cellular quiescence" EXACT [GOC:mah] +synonym: "G0 phase" RELATED [GOC:mah] +synonym: "quiescence" BROAD [GOC:mah] +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0044839 +name: cell cycle G2/M phase transition +namespace: biological_process +def: "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] +is_a: GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:0044840 +name: gut granule +namespace: cellular_component +def: "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage." [GOC:kmv, PMID:22916203, PMID:24204312] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0044841 +name: gut granule membrane +namespace: cellular_component +def: "The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0044840 ! gut granule + +[Term] +id: GO:0044842 +name: gut granule lumen +namespace: cellular_component +def: "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0044840 ! gut granule + +[Term] +id: GO:0044843 +name: cell cycle G1/S phase transition +namespace: biological_process +def: "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] +is_a: GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:0044844 +name: meiotic interphase II +namespace: biological_process +def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0051328 ! meiotic interphase +is_a: GO:0098765 ! meiosis II cell cycle phase + +[Term] +id: GO:0044845 +name: chain elongation of O-linked mannose residue +namespace: biological_process +def: "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules." [GOC:jl, PMID:19429925] +comment: Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family. +is_a: GO:0035268 ! protein mannosylation + +[Term] +id: GO:0044846 +name: negative regulation by symbiont of indole acetic acid levels in host +namespace: biological_process +def: "Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646] +synonym: "negative regulation by symbiont of auxin levels in host" EXACT [] +synonym: "negative regulation by symbiont of IAA levels in host" EXACT [] +is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host + +[Term] +id: GO:0044847 +name: iron acquisition from host +namespace: biological_process +alt_id: GO:0052099 +def: "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell." [PMID:15487950, PMID:22865843] +synonym: "acquisition by organism of nutrients from host via siderophores" RELATED [] +synonym: "acquisition by symbiont of nutrients from host via siderophores" NARROW [] +synonym: "heme acquisition" RELATED [] +synonym: "iron acquisition" BROAD [] +synonym: "iron acquisition by symbiont from host" EXACT [] +synonym: "iron acquisition by symbiont from host heme" NARROW [] +is_a: GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0044848 +name: biological phase +namespace: biological_process +def: "A distinct period or stage in a biological process or cycle." [GOC:jl] +comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. +subset: gocheck_do_not_manually_annotate +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0044849 +name: estrous cycle +namespace: biological_process +def: "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur." [GOC:jl, Wikipedia:Estrous_cycle] +xref: Wikipedia:Estrous_cycle +is_a: GO:0042698 ! ovulation cycle + +[Term] +id: GO:0044850 +name: menstrual cycle +namespace: biological_process +def: "A type of ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:jl] +xref: Wikipedia:Menstrual_cycle +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0042698 ! ovulation cycle + +[Term] +id: GO:0044851 +name: hair cycle phase +namespace: biological_process +def: "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0044848 ! biological phase + +[Term] +id: GO:0044852 +name: nonrepetitive DNA condensation +namespace: biological_process +def: "The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells." [GOC:jl, PMID:10811823] +synonym: "nonrepetitive DNA packaging" EXACT [] +is_a: GO:0006323 ! DNA packaging +relationship: part_of GO:0030261 ! chromosome condensation + +[Term] +id: GO:0044853 +name: plasma membrane raft +namespace: cellular_component +def: "A membrane raft that is part of the plasma membrane." [GOC:jl] +is_a: GO:0045121 ! membrane raft +is_a: GO:0098590 ! plasma membrane region + +[Term] +id: GO:0044854 +name: plasma membrane raft assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft." [GOC:jl] +is_a: GO:0001765 ! membrane raft assembly +is_a: GO:0044857 ! plasma membrane raft organization + +[Term] +id: GO:0044855 +name: plasma membrane raft distribution +namespace: biological_process +def: "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane." [GOC:jl] +is_a: GO:0031580 ! membrane raft distribution +is_a: GO:0044856 ! plasma membrane raft localization + +[Term] +id: GO:0044856 +name: plasma membrane raft localization +namespace: biological_process +def: "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location." [GOC:jl] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0051665 ! membrane raft localization + +[Term] +id: GO:0044857 +name: plasma membrane raft organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts." [GOC:jl] +is_a: GO:0031579 ! membrane raft organization +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0044858 +name: plasma membrane raft polarization +namespace: biological_process +def: "The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:jl] +synonym: "plasma membrane polarization" EXACT [] +is_a: GO:0001766 ! membrane raft polarization +is_a: GO:0044855 ! plasma membrane raft distribution + +[Term] +id: GO:0044859 +name: protein insertion into plasma membrane raft +namespace: biological_process +def: "The process in which a protein is incorporated into a plasma membrane raft." [GOC:jl] +is_a: GO:0044860 ! protein localization to plasma membrane raft +is_a: GO:0071210 ! protein insertion into membrane raft +is_a: GO:0098737 ! protein insertion into plasma membrane + +[Term] +id: GO:0044860 +name: protein localization to plasma membrane raft +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft." [GOC:jl] +is_a: GO:1903044 ! protein localization to membrane raft +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0044861 +name: protein transport into plasma membrane raft +namespace: biological_process +def: "The directed movement of a protein into a plasma membrane raft." [GOC:jl] +is_a: GO:0032596 ! protein transport into membrane raft +is_a: GO:0044860 ! protein localization to plasma membrane raft + +[Term] +id: GO:0044862 +name: protein transport out of plasma membrane raft +namespace: biological_process +def: "The directed movement of a protein out of a plasma membrane raft." [GOC:jl] +is_a: GO:0032599 ! protein transport out of membrane raft +is_a: GO:0090150 ! establishment of protein localization to membrane +is_a: GO:0099632 ! protein transport within plasma membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0044863 +name: modulation by virus of host cell division +namespace: biological_process +def: "Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells." [GOC:jl] +synonym: "regulation by virus of host cell division" EXACT [] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0051302 ! regulation of cell division + +[Term] +id: GO:0044864 +name: positive regulation by virus of host cell division +namespace: biological_process +def: "Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division." [GOC:jl] +is_a: GO:0044863 ! modulation by virus of host cell division +is_a: GO:0051781 ! positive regulation of cell division + +[Term] +id: GO:0044865 +name: negative regulation by virus of host cell division +namespace: biological_process +def: "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division." [GOC:jl] +synonym: "inhibition by virus of host cell division" NARROW [] +is_a: GO:0044863 ! modulation by virus of host cell division +is_a: GO:0051782 ! negative regulation of cell division + +[Term] +id: GO:0044866 +name: modulation by host of viral exo-alpha-sialidase activity +namespace: biological_process +def: "The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl] +is_a: GO:0044867 ! modulation by host of viral catalytic activity + +[Term] +id: GO:0044867 +name: modulation by host of viral catalytic activity +namespace: biological_process +def: "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected." [GOC:jl] +is_a: GO:0044868 ! modulation by host of viral molecular function + +[Term] +id: GO:0044868 +name: modulation by host of viral molecular function +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected." [GOC:jl] +is_a: GO:0044788 ! modulation by host of viral process + +[Term] +id: GO:0044869 +name: negative regulation by host of viral exo-alpha-sialidase activity +namespace: biological_process +def: "The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl] +is_a: GO:0044866 ! modulation by host of viral exo-alpha-sialidase activity +is_a: GO:0052403 ! negative regulation by host of symbiont catalytic activity + +[Term] +id: GO:0044870 +name: modulation by host of viral glycoprotein metabolic process +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl] +is_a: GO:0044788 ! modulation by host of viral process +relationship: regulates GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0044871 +name: negative regulation by host of viral glycoprotein metabolic process +namespace: biological_process +def: "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl] +is_a: GO:0044793 ! negative regulation by host of viral process +is_a: GO:0044870 ! modulation by host of viral glycoprotein metabolic process +is_a: GO:0048525 ! negative regulation of viral process +is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process + +[Term] +id: GO:0044872 +name: lipoprotein localization +namespace: biological_process +def: "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0044873 +name: lipoprotein localization to membrane +namespace: biological_process +def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl] +is_a: GO:0044872 ! lipoprotein localization +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:0044874 +name: lipoprotein localization to outer membrane +namespace: biological_process +def: "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl] +is_a: GO:0044873 ! lipoprotein localization to membrane + +[Term] +id: GO:0044875 +name: gamma-glutamyl hercynylcysteine sulfoxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577, RHEA:42672] +synonym: "gamma-glutamyl hercynylcysteine S-oxide synthase" EXACT [GOC:dph] +synonym: "gamma-glutamyl hercynylcysteine sulfoxide synthase" EXACT [] +xref: EC:1.14.99.50 +xref: RHEA:42672 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0044876 +name: hercynylselenocysteine synthase +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine." [GOC:jl, PMID:24828577, RHEA:42680] +xref: MetaCyc:RXN-15803 +xref: RHEA:42680 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0044877 +name: protein-containing complex binding +namespace: molecular_function +alt_id: GO:0032403 +def: "Binding to a macromolecular complex." [GOC:jl] +subset: goslim_chembl +synonym: "macromolecular complex binding" RELATED [] +synonym: "protein complex binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0044878 +name: mitotic cytokinesis checkpoint signaling +namespace: biological_process +alt_id: GO:1903820 +def: "A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed." [GOC:jl, GOC:mtg_cell_cycle, PMID:17538026] +synonym: "cytokinesis after mitosis checkpoint" RELATED [GOC:dph, GOC:vw] +synonym: "defective cytokinesis checkpoint" RELATED [GOC:dph, GOC:vw] +synonym: "mitotic cytokinesis checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic cytokinesis checkpoint" EXACT [] +synonym: "signaling pathway involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling cascade involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling pathway involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle + +[Term] +id: GO:0044879 +name: mitotic morphogenesis checkpoint signaling +namespace: biological_process +alt_id: GO:1903822 +def: "A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth." [GOC:jl, GOC:mtg_cell_cycle] +synonym: "morphogenesis checkpoint" EXACT [] +synonym: "septin checkpoint" EXACT [] +synonym: "signal transduction involved in morphogenesis checkpoint" EXACT [] +synonym: "signal transduction involved in septin checkpoint" EXACT [GOC:TermGenie] +synonym: "signaling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signaling cascade involved in septin checkpoint" EXACT [GOC:TermGenie] +synonym: "signaling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signaling pathway involved in septin checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling cascade involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling cascade involved in septin checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling pathway involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "signalling pathway involved in septin checkpoint" EXACT [GOC:TermGenie] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling + +[Term] +id: GO:0045002 +name: double-strand break repair via single-strand annealing +namespace: biological_process +def: "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529] +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0045003 +name: double-strand break repair via synthesis-dependent strand annealing +namespace: biological_process +def: "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855] +synonym: "mitotic gene conversion" RELATED [] +synonym: "SDSA" BROAD [] +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0045004 +name: DNA replication proofreading +namespace: biological_process +def: "Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity." [GOC:ai] +is_a: GO:0006281 ! DNA repair +is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity + +[Term] +id: GO:0045005 +name: DNA-dependent DNA replication maintenance of fidelity +namespace: biological_process +def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] +synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of fidelity involved in DNA-dependent DNA replication" EXACT [] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0045006 +name: DNA deamination +namespace: biological_process +def: "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0045007 +name: depurination +namespace: biological_process +def: "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai] +xref: Wikipedia:Depurination +is_a: GO:0006285 ! base-excision repair, AP site formation +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0045008 +name: depyrimidination +namespace: biological_process +def: "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai] +is_a: GO:0006285 ! base-excision repair, AP site formation +is_a: GO:0006304 ! DNA modification +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process + +[Term] +id: GO:0045009 +name: chitosome +namespace: cellular_component +def: "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0045010 +name: actin nucleation +namespace: biological_process +def: "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194] +synonym: "actin filament nucleation" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0045012 +name: obsolete MHC class II receptor activity +namespace: molecular_function +def: "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971] +comment: This term was made obsolete because it was defined ambiguously, and has therefore been used incorrectly in annotations. To update annotations of gene products that act as receptors for MHC class II protein complexes, use the molecular function term 'MHC class II receptor activity ; GO:0032395'; to update annotations of gene products which are components of MHC class II protein complexes, use the cellular component term 'MHC class II protein complex ; GO:0042613'. +synonym: "class II major histocompatibility complex antigen" RELATED [] +synonym: "major histocompatibility complex class II receptor" EXACT [] +synonym: "MHC class II receptor activity" EXACT [] +is_obsolete: true +consider: GO:0032395 +consider: GO:0042613 + +[Term] +id: GO:0045013 +name: carbon catabolite repression of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445] +synonym: "carbon catabolite repression" RELATED [GOC:dph] +synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0045990 ! carbon catabolite regulation of transcription +is_a: GO:0061985 ! carbon catabolite repression + +[Term] +id: GO:0045014 +name: carbon catabolite repression of transcription by glucose +namespace: biological_process +def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [ISBN:0198506732, PMID:11018147] +synonym: "down regulation of transcription by glucose" EXACT [] +synonym: "down-regulation of transcription by glucose" EXACT [] +synonym: "downregulation of transcription by glucose" EXACT [] +synonym: "glucose effect" EXACT [] +synonym: "glucose repression" EXACT [] +synonym: "inhibition of transcription by glucose" NARROW [] +is_a: GO:0045013 ! carbon catabolite repression of transcription +is_a: GO:0061986 ! negative regulation of transcription by glucose + +[Term] +id: GO:0045015 +name: HDEL sequence binding +namespace: molecular_function +def: "Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759] +synonym: "HDEL receptor activity" NARROW [] +is_a: GO:0046923 ! ER retention sequence binding + +[Term] +id: GO:0045016 +name: mitochondrial magnesium ion transmembrane transport +namespace: biological_process +alt_id: GO:1990614 +def: "The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai, PMID:11254124] +synonym: "mitochondrial magnesium ion transport" RELATED [] +is_a: GO:1903830 ! magnesium ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0045017 +name: glycerolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] +synonym: "glycerolipid anabolism" EXACT [] +synonym: "glycerolipid biosynthesis" EXACT [] +synonym: "glycerolipid formation" EXACT [] +synonym: "glycerolipid synthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0045018 +name: retrograde transport, vacuole to Golgi +namespace: biological_process +def: "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156] +synonym: "retrograde transport from the vacuole" EXACT [] +is_a: GO:0007034 ! vacuolar transport + +[Term] +id: GO:0045019 +name: negative regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "down regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "down-regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "downregulation of nitric oxide biosynthetic process" EXACT [] +synonym: "inhibition of nitric oxide biosynthetic process" NARROW [] +synonym: "negative regulation of nitric oxide anabolism" EXACT [] +synonym: "negative regulation of nitric oxide biosynthesis" EXACT [] +synonym: "negative regulation of nitric oxide formation" EXACT [] +synonym: "negative regulation of nitric oxide synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process +is_a: GO:1904406 ! negative regulation of nitric oxide metabolic process +relationship: negatively_regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045020 +name: obsolete error-prone DNA repair +namespace: biological_process +def: "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974] +comment: This term was made obsolete because 'error-prone' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. +synonym: "error-prone DNA repair" EXACT [] +synonym: "mutagenic DNA repair" EXACT [] +is_obsolete: true +consider: GO:0042276 + +[Term] +id: GO:0045021 +name: obsolete error-free DNA repair +namespace: biological_process +def: "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974] +comment: This term was made obsolete because 'error-free' does not correspond to a repair mechanism, and the term has been superseded by more specific terms. +synonym: "error-free DNA repair" EXACT [] +is_obsolete: true +consider: GO:0042275 +consider: GO:0070987 + +[Term] +id: GO:0045022 +name: early endosome to late endosome transport +namespace: biological_process +def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments + +[Term] +id: GO:0045023 +name: G0 to G1 transition +namespace: biological_process +def: "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0045024 +name: obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414] +comment: This term was made obsolete because it represents a gene product. +synonym: "peptidyl-glutamyl peptide hydrolyzing enzyme activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008233 + +[Term] +id: GO:0045025 +name: mitochondrial degradosome +namespace: cellular_component +def: "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834] +synonym: "mtEXO" EXACT [PMID:10397341, PMID:9829834] +is_a: GO:0000177 ! cytoplasmic exosome (RNase complex) +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0045026 +name: plasma membrane fusion +namespace: biological_process +alt_id: GO:0006947 +def: "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." [GOC:elh, GOC:mtg_muscle] +synonym: "cell fusion" BROAD [] +synonym: "cell-cell fusion" BROAD [] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0061025 ! membrane fusion + +[Term] +id: GO:0045027 +name: DNA end binding +namespace: molecular_function +def: "Binding to DNA ends exposed by the creation of double-strand breaks (DSBs)." [GOC:jl] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0045028 +name: G protein-coupled purinergic nucleotide receptor activity +namespace: molecular_function +def: "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289] +synonym: "G protein coupled purinergic nucleotide receptor activity" EXACT [] +synonym: "G-protein coupled purinergic nucleotide receptor activity" EXACT [] +synonym: "P2Y" RELATED [] +synonym: "P2Y receptor" RELATED [PMID:9755289] +synonym: "purinergic nucleotide receptor activity, G protein coupled" EXACT [] +synonym: "purinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0001614 ! purinergic nucleotide receptor activity +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0045029 +name: G protein-coupled UDP receptor activity +namespace: molecular_function +def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah] +synonym: "UDP-activated nucleotide receptor activity" BROAD [] +is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity + +[Term] +id: GO:0045030 +name: G protein-coupled UTP receptor activity +namespace: molecular_function +alt_id: GO:0015065 +def: "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah] +synonym: "purinoceptor type U" BROAD [] +synonym: "uridine nucleotide receptor activity" BROAD [] +synonym: "UTP-activated nucleotide receptor activity" BROAD [] +is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity + +[Term] +id: GO:0045031 +name: G protein-coupled ATP receptor activity +namespace: molecular_function +def: "Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah] +synonym: "ATP-activated adenosine receptor activity" RELATED [] +synonym: "ATP-activated nucleotide receptor activity" BROAD [] +is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity + +[Term] +id: GO:0045033 +name: peroxisome inheritance +namespace: biological_process +def: "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545] +comment: Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. +is_a: GO:0007031 ! peroxisome organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0045034 +name: obsolete neuroblast division +namespace: biological_process +alt_id: GO:0043345 +alt_id: GO:0043346 +def: "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167] +comment: This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division. +synonym: "neuroblast cell division" EXACT [] +synonym: "neuroblast division" EXACT [] +synonym: "neuroblast division (sensu Nematoda and Protostomia)" EXACT [] +synonym: "neuroblast division (sensu Vertebrata)" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045035 +name: sensory organ precursor cell division +namespace: biological_process +def: "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597] +synonym: "sense organ precursor cell division" EXACT [GOC:dph] +is_a: GO:0008356 ! asymmetric cell division +relationship: part_of GO:0007423 ! sensory organ development + +[Term] +id: GO:0045036 +name: protein targeting to chloroplast +namespace: biological_process +def: "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363] +synonym: "protein-chloroplast targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0072596 ! establishment of protein localization to chloroplast + +[Term] +id: GO:0045037 +name: protein import into chloroplast stroma +namespace: biological_process +def: "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363] +synonym: "chloroplast stroma protein import" EXACT [] +synonym: "protein transport into chloroplast stroma" EXACT [] +is_a: GO:0017038 ! protein import +is_a: GO:0045036 ! protein targeting to chloroplast +is_a: GO:0065002 ! intracellular protein transmembrane transport + +[Term] +id: GO:0045038 +name: protein import into chloroplast thylakoid membrane +namespace: biological_process +def: "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363] +synonym: "chloroplast thylakoid membrane protein import" EXACT [] +synonym: "protein transport into chloroplast thylakoid membrane" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane +is_a: GO:0044743 ! protein transmembrane import into intracellular organelle +is_a: GO:0045036 ! protein targeting to chloroplast +is_a: GO:0065002 ! intracellular protein transmembrane transport + +[Term] +id: GO:0045039 +name: protein insertion into mitochondrial inner membrane +namespace: biological_process +def: "The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." [GOC:mcc, GOC:vw, PMID:18672008] +synonym: "mitochondrial inner membrane protein import" EXACT [] +synonym: "protein import into mitochondrial inner membrane" EXACT [] +synonym: "protein transport into mitochondrial inner membrane" EXACT [] +is_a: GO:0007007 ! inner mitochondrial membrane organization +is_a: GO:0051204 ! protein insertion into mitochondrial membrane +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0045040 +name: protein insertion into mitochondrial outer membrane +namespace: biological_process +def: "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008] +synonym: "mitochondrial outer membrane protein import" EXACT [] +synonym: "protein import into mitochondrial outer membrane" EXACT [] +synonym: "protein transport into mitochondrial outer membrane" EXACT [] +is_a: GO:0007008 ! outer mitochondrial membrane organization +is_a: GO:0017038 ! protein import +is_a: GO:0051204 ! protein insertion into mitochondrial membrane +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0045041 +name: protein import into mitochondrial intermembrane space +namespace: biological_process +alt_id: GO:0045043 +alt_id: GO:0045044 +def: "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363] +synonym: "mitochondrial intermembrane space protein import" EXACT [] +synonym: "protein import into mitochondrial IMS" EXACT [] +synonym: "protein import into mitochondrial intermembrane space, direct" NARROW [GOC:mcc] +synonym: "protein import into mitochondrial intermembrane space, nonconservative" NARROW [GOC:mcc] +synonym: "protein transport into mitochondrial IMS" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0044743 ! protein transmembrane import into intracellular organelle +is_a: GO:0065002 ! intracellular protein transmembrane transport +is_a: GO:0072655 ! establishment of protein localization to mitochondrion +is_a: GO:1990542 ! mitochondrial transmembrane transport +relationship: part_of GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:0045042 +name: obsolete protein import into mitochondrial intermembrane space, conservative +namespace: biological_process +def: "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363] +comment: This term was made obsolete because there is no 'conservative' process of protein import into the mitochondrial intermembrane space that is distinct from the more general parent; furthermore, 'conservative' is used in the literature to describe a pathway of import into the inner membrane rather than into the intermembrane space. +synonym: "conservative mitochondrial IMS protein import" EXACT [] +synonym: "conservative mitochondrial intermembrane space protein import" EXACT [] +synonym: "conservative protein transport into mitochondrial IMS" EXACT [] +synonym: "conservative protein transport into mitochondrial intermembrane space" EXACT [] +synonym: "protein import into mitochondrial IMS, conservative" EXACT [] +synonym: "protein import into mitochondrial intermembrane space, conservative" EXACT [] +synonym: "protein transport into mitochondrial IMS, conservative" EXACT [] +synonym: "protein transport into mitochondrial intermembrane space, conservative" EXACT [] +is_obsolete: true +consider: GO:0045039 +consider: GO:0045041 + +[Term] +id: GO:0045045 +name: obsolete secretory pathway +namespace: biological_process +def: "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363] +comment: This term was made obsolete because it artificially groups a number of other terms, leading to path problems, its definition is unclear (and lacks genus-differentia features), and it has probably been used incorrectly in annotations. +synonym: "secretory pathway" EXACT [] +is_obsolete: true +replaced_by: GO:0032940 + +[Term] +id: GO:0045046 +name: protein import into peroxisome membrane +namespace: biological_process +def: "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502] +synonym: "peroxisome membrane protein import" EXACT [] +synonym: "protein transport into peroxisome membrane" EXACT [] +is_a: GO:0006612 ! protein targeting to membrane +is_a: GO:0006625 ! protein targeting to peroxisome +is_a: GO:0015919 ! peroxisomal membrane transport +is_a: GO:0017038 ! protein import + +[Term] +id: GO:0045047 +name: protein targeting to ER +namespace: biological_process +def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363] +synonym: "protein targeting to endoplasmic reticulum" EXACT [] +synonym: "protein-endoplasmic reticulum targeting" EXACT [] +synonym: "protein-ER targeting" EXACT [] +is_a: GO:0006605 ! protein targeting +is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum + +[Term] +id: GO:0045048 +name: protein insertion into ER membrane +namespace: biological_process +def: "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363] +synonym: "integral ER membrane protein localization" EXACT [] +synonym: "integral ER membrane protein positioning" EXACT [] +synonym: "localization of protein in ER membrane" EXACT [] +synonym: "positioning of protein in ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane" EXACT [] +synonym: "protein-endoplasmic reticulum insertion" EXACT [] +synonym: "protein-ER insertion" EXACT [] +is_a: GO:0051205 ! protein insertion into membrane +relationship: part_of GO:0007029 ! endoplasmic reticulum organization +relationship: part_of GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0045049 +name: protein insertion into ER membrane by N-terminal cleaved signal sequence +namespace: biological_process +def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363] +synonym: "N-terminal cleaved signal sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence" EXACT [] +synonym: "protein insertion into ER membrane, N-terminal cleaved signal sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence" EXACT [] +synonym: "protein-ER insertion by N-terminal cleaved signal sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045050 +name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence +namespace: biological_process +def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363] +synonym: "protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "protein-ER insertion by stop-transfer membrane-anchor sequence" EXACT [] +synonym: "stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045051 +name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence +namespace: biological_process +def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363] +synonym: "internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence" EXACT [] +synonym: "protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence" EXACT [] +synonym: "protein-ER insertion by internal uncleaved signal-anchor sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045052 +name: protein insertion into ER membrane by GPI attachment sequence +namespace: biological_process +def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363] +synonym: "GPI attachment sequence mediated protein insertion into ER membrane" EXACT [] +synonym: "protein insertion into endoplasmic reticulum membrane by GPI attachment sequence" EXACT [] +synonym: "protein insertion into ER membrane, GPI attachment sequence mediated" EXACT [] +synonym: "protein-endoplasmic reticulum insertion by GPI attachment sequence" EXACT [] +synonym: "protein-ER insertion by GPI attachment sequence" EXACT [] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0045053 +name: protein retention in Golgi apparatus +namespace: biological_process +def: "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363] +synonym: "maintenance of protein location in Golgi apparatus" RELATED [] +synonym: "protein-Golgi retention" EXACT [] +synonym: "retention of protein in Golgi" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0034067 ! protein localization to Golgi apparatus + +[Term] +id: GO:0045054 +name: constitutive secretory pathway +namespace: biological_process +def: "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363] +synonym: "constitutive exocytosis" EXACT [] +is_a: GO:0006887 ! exocytosis + +[Term] +id: GO:0045055 +name: regulated exocytosis +namespace: biological_process +def: "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363] +synonym: "regulated secretory pathway" EXACT [] +is_a: GO:0006887 ! exocytosis + +[Term] +id: GO:0045056 +name: transcytosis +namespace: biological_process +def: "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363] +xref: Wikipedia:Transcytosis +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0045057 +name: cisternal progression +namespace: biological_process +def: "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363] +synonym: "cisternal maturation" EXACT [] +is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport + +[Term] +id: GO:0045058 +name: T cell selection +namespace: biological_process +def: "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722] +synonym: "T lymphocyte selection" EXACT [] +synonym: "T-cell selection" EXACT [] +synonym: "T-lymphocyte selection" EXACT [] +xref: Wikipedia:Thymocyte +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045059 +name: positive thymic T cell selection +namespace: biological_process +def: "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722] +synonym: "positive thymic T lymphocyte selection" EXACT [] +synonym: "positive thymic T-cell selection" EXACT [] +synonym: "positive thymic T-lymphocyte selection" EXACT [] +is_a: GO:0043368 ! positive T cell selection +is_a: GO:0045061 ! thymic T cell selection + +[Term] +id: GO:0045060 +name: negative thymic T cell selection +namespace: biological_process +def: "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722] +synonym: "negative thymic T lymphocyte selection" EXACT [] +synonym: "negative thymic T-cell selection" EXACT [] +synonym: "negative thymic T-lymphocyte selection" EXACT [] +is_a: GO:0043383 ! negative T cell selection +is_a: GO:0045061 ! thymic T cell selection + +[Term] +id: GO:0045061 +name: thymic T cell selection +namespace: biological_process +def: "The process of T cell selection that occurs in the thymus." [ISBN:0781735149, PMID:12414722] +synonym: "thymic T lymphocyte selection" EXACT [] +synonym: "thymic T-cell selection" EXACT [] +synonym: "thymic T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:0045062 +name: extrathymic T cell selection +namespace: biological_process +def: "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149, PMID:7880383] +synonym: "extrathymic T lymphocyte selection" EXACT [] +synonym: "extrathymic T-cell selection" EXACT [] +synonym: "extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0045058 ! T cell selection +relationship: part_of GO:0033078 ! extrathymic T cell differentiation + +[Term] +id: GO:0045063 +name: T-helper 1 cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T-helper 1 cell development" RELATED [GOC:add] +is_a: GO:0042093 ! T-helper cell differentiation +relationship: part_of GO:0042088 ! T-helper 1 type immune response + +[Term] +id: GO:0045064 +name: T-helper 2 cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T-helper 2 cell development" RELATED [GOC:add] +is_a: GO:0042093 ! T-helper cell differentiation +relationship: part_of GO:0042092 ! type 2 immune response + +[Term] +id: GO:0045065 +name: cytotoxic T cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "cytotoxic T cell development" RELATED [GOC:add] +synonym: "cytotoxic T lymphocyte selection" EXACT [] +synonym: "cytotoxic T-cell selection" EXACT [] +synonym: "cytotoxic T-lymphocyte selection" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045066 +name: regulatory T cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulatory T cell development" RELATED [GOC:add] +synonym: "regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulatory T-cell differentiation" EXACT [] +synonym: "regulatory T-lymphocyte differentiation" EXACT [] +synonym: "suppressor T cell differentiation" EXACT [] +synonym: "suppressor T lymphocyte differentiation" EXACT [] +synonym: "suppressor T-cell differentiation" EXACT [] +synonym: "suppressor T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045067 +name: positive extrathymic T cell selection +namespace: biological_process +def: "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:7880383] +synonym: "positive extrathymic T lymphocyte selection" EXACT [] +synonym: "positive extrathymic T-cell selection" EXACT [] +synonym: "positive extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0043368 ! positive T cell selection +is_a: GO:0045062 ! extrathymic T cell selection + +[Term] +id: GO:0045068 +name: negative extrathymic T cell selection +namespace: biological_process +def: "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:7880383] +synonym: "negative extrathymic T lymphocyte selection" EXACT [] +synonym: "negative extrathymic T-cell selection" EXACT [] +synonym: "negative extrathymic T-lymphocyte selection" EXACT [] +is_a: GO:0043383 ! negative T cell selection +is_a: GO:0045062 ! extrathymic T cell selection + +[Term] +id: GO:0045069 +name: regulation of viral genome replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral genome replication." [GOC:ai] +is_a: GO:1903900 ! regulation of viral life cycle +relationship: regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045070 +name: positive regulation of viral genome replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai] +synonym: "activation of viral genome replication" NARROW [] +synonym: "stimulation of viral genome replication" NARROW [] +synonym: "up regulation of viral genome replication" EXACT [] +synonym: "up-regulation of viral genome replication" EXACT [] +synonym: "upregulation of viral genome replication" EXACT [] +is_a: GO:0045069 ! regulation of viral genome replication +is_a: GO:0048524 ! positive regulation of viral process +relationship: positively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045071 +name: negative regulation of viral genome replication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators] +synonym: "down regulation of viral genome replication" EXACT [] +synonym: "down-regulation of viral genome replication" EXACT [] +synonym: "downregulation of viral genome replication" EXACT [] +synonym: "inhibition of viral genome replication" NARROW [] +is_a: GO:0045069 ! regulation of viral genome replication +is_a: GO:0048525 ! negative regulation of viral process +relationship: negatively_regulates GO:0019079 ! viral genome replication + +[Term] +id: GO:0045087 +name: innate immune response +namespace: biological_process +alt_id: GO:0002226 +def: "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] +synonym: "innate immunity" EXACT [GOC:pg] +synonym: "nonspecific immune response" EXACT [] +xref: Wikipedia:Innate_immune_system +is_a: GO:0006955 ! immune response +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0045088 +name: regulation of innate immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045089 +name: positive regulation of innate immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc] +synonym: "stimulation of innate immune response" NARROW [] +synonym: "up regulation of innate immune response" EXACT [] +synonym: "up-regulation of innate immune response" EXACT [] +synonym: "upregulation of innate immune response" EXACT [] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045091 +name: regulation of single stranded viral RNA replication via double stranded DNA intermediate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators] +synonym: "regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] +is_a: GO:0045069 ! regulation of viral genome replication +relationship: regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate + +[Term] +id: GO:0045092 +name: interleukin-18 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435] +synonym: "IL-18 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0045093 +name: obsolete interleukin-18 alpha subunit binding +namespace: molecular_function +def: "OBSOLETE. Binding to alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850] +comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits +synonym: "IL-18Ra binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045094 +name: obsolete interleukin-18 beta subunit binding +namespace: molecular_function +def: "OBSOLETE. Binding to beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850] +comment: This term was obsoleted because interleukin-18 is a single polypeptide and has no subunits. +synonym: "IL-18Rb binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045095 +name: keratin filament +namespace: cellular_component +def: "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363] +synonym: "acidic keratin" RELATED [] +synonym: "basic/neutral keratin" RELATED [] +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0045096 +name: obsolete acidic keratin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +synonym: "acidic keratin" EXACT [] +synonym: "type I intermediate filament" EXACT [] +is_obsolete: true +replaced_by: GO:0045095 + +[Term] +id: GO:0045097 +name: obsolete basic/neutral keratin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363, ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +synonym: "basic/neutral keratin" EXACT [] +synonym: "type II intermediate filament" EXACT [] +is_obsolete: true +replaced_by: GO:0045095 + +[Term] +id: GO:0045098 +name: type III intermediate filament +namespace: cellular_component +def: "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363] +synonym: "desmin" NARROW [] +synonym: "glial fibrillary acidic protein" NARROW [] +synonym: "peripherin" NARROW [] +synonym: "type III intermediate filament associated protein" NARROW [] +synonym: "vimentin" NARROW [] +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0045099 +name: obsolete vimentin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +synonym: "vimentin" EXACT [] +is_obsolete: true +replaced_by: GO:0045098 + +[Term] +id: GO:0045100 +name: obsolete desmin +namespace: cellular_component +def: "OBSOLETE. A type of intermediate filament." [ISBN:0815316194] +comment: This term was made obsolete because it represents a gene product. +synonym: "desmin" EXACT [] +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045101 +name: obsolete glial fibrillary acidic protein +namespace: cellular_component +def: "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +synonym: "GFAP" EXACT [] +synonym: "glial fibrillary acidic protein" EXACT [] +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045102 +name: obsolete peripherin +namespace: cellular_component +def: "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363] +comment: This term was made obsolete because it represents a gene product. +synonym: "peripherin" EXACT [] +is_obsolete: true +consider: GO:0045098 + +[Term] +id: GO:0045103 +name: intermediate filament-based process +namespace: biological_process +def: "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0045104 +name: intermediate filament cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai] +synonym: "intermediate filament cytoskeleton organisation" EXACT [] +synonym: "intermediate filament cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0007010 ! cytoskeleton organization +is_a: GO:0045103 ! intermediate filament-based process + +[Term] +id: GO:0045105 +name: intermediate filament polymerization or depolymerization +namespace: biological_process +def: "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai] +is_a: GO:0043933 ! protein-containing complex organization +relationship: part_of GO:0045104 ! intermediate filament cytoskeleton organization + +[Term] +id: GO:0045106 +name: intermediate filament depolymerization +namespace: biological_process +def: "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363] +is_a: GO:0045105 ! intermediate filament polymerization or depolymerization +is_a: GO:0051261 ! protein depolymerization + +[Term] +id: GO:0045107 +name: intermediate filament polymerization +namespace: biological_process +def: "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884] +is_a: GO:0045105 ! intermediate filament polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization + +[Term] +id: GO:0045108 +name: regulation of intermediate filament polymerization or depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0045105 ! intermediate filament polymerization or depolymerization + +[Term] +id: GO:0045109 +name: intermediate filament organization +namespace: biological_process +def: "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai] +synonym: "intermediate filament organisation" EXACT [] +is_a: GO:0045104 ! intermediate filament cytoskeleton organization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0045110 +name: intermediate filament bundle assembly +namespace: biological_process +def: "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363] +synonym: "tonofilament assembly" NARROW [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0045109 ! intermediate filament organization + +[Term] +id: GO:0045111 +name: intermediate filament cytoskeleton +namespace: cellular_component +def: "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363] +is_a: GO:0005856 ! cytoskeleton + +[Term] +id: GO:0045112 +name: integrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732] +synonym: "integrin anabolism" EXACT [] +synonym: "integrin biosynthesis" EXACT [] +synonym: "integrin formation" EXACT [] +synonym: "integrin synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process +relationship: part_of GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0045113 +name: regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "regulation of integrin anabolism" EXACT [] +synonym: "regulation of integrin biosynthesis" EXACT [] +synonym: "regulation of integrin formation" EXACT [] +synonym: "regulation of integrin synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045114 +name: beta 2 integrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators] +synonym: "beta 2 integrin anabolism" EXACT [] +synonym: "beta 2 integrin biosynthesis" EXACT [] +synonym: "beta 2 integrin formation" EXACT [] +synonym: "beta 2 integrin synthesis" EXACT [] +is_a: GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045115 +name: regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "regulation of beta 2 integrin anabolism" EXACT [] +synonym: "regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "regulation of beta 2 integrin formation" EXACT [] +synonym: "regulation of beta 2 integrin synthesis" EXACT [] +is_a: GO:0045113 ! regulation of integrin biosynthetic process +relationship: regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045116 +name: protein neddylation +namespace: biological_process +alt_id: GO:0019943 +def: "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580] +comment: Note that currently, the only known substrates of neddylation are cullin family proteins. +synonym: "RUB1-protein conjugation" EXACT [] +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0045117 +name: azole transmembrane transport +namespace: biological_process +def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] +synonym: "azole transport" RELATED [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0045119 +name: azole:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole] +synonym: "azole:hydrogen antiporter activity" EXACT [] +synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" NARROW [] +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:0045120 +name: pronucleus +namespace: cellular_component +def: "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732] +xref: Wikipedia:Pronucleus +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0045121 +name: membrane raft +namespace: cellular_component +def: "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567] +synonym: "GEM domain" RELATED [] +synonym: "glycolipid-enriched membrane domain" RELATED [] +synonym: "lipid raft" EXACT [] +xref: Wikipedia:Lipid_raft +is_a: GO:0098857 ! membrane microdomain + +[Term] +id: GO:0045122 +name: aflatoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194, PMID:15006741] +synonym: "aflatoxin anabolism" EXACT [] +synonym: "aflatoxin biosynthesis" EXACT [] +synonym: "aflatoxin formation" EXACT [] +synonym: "aflatoxin synthesis" EXACT [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0046222 ! aflatoxin metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:0045123 +name: cellular extravasation +namespace: biological_process +def: "The migration of a leukocyte from the blood vessels into the surrounding tissue." [GOC:jl] +synonym: "immune cell cellular extravasation" EXACT [] +synonym: "leucocyte cellular extravasation" EXACT [] +synonym: "leukocyte cellular extravasation" EXACT [] +synonym: "transendothelial leukocyte migration" EXACT [GOC:rl] +xref: Wikipedia:Leukocyte_extravasation +is_a: GO:0050900 ! leukocyte migration + +[Term] +id: GO:0045124 +name: regulation of bone resorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai] +is_a: GO:0046850 ! regulation of bone remodeling +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045125 +name: bioactive lipid receptor activity +namespace: molecular_function +def: "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0045127 +name: N-acetylglucosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17417] +synonym: "2-acetylamino-2-deoxy-D-glucose kinase activity" RELATED [EC:2.7.1.59] +synonym: "acetylaminodeoxyglucokinase activity" RELATED [EC:2.7.1.59] +synonym: "acetylglucosamine kinase (phosphorylating)" RELATED [EC:2.7.1.59] +synonym: "ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.59] +synonym: "ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity" RELATED [EC:2.7.1.59] +synonym: "GlcNAc kinase activity" RELATED [EC:2.7.1.59] +xref: EC:2.7.1.59 +xref: KEGG_REACTION:R01201 +xref: MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN +xref: Reactome:R-HSA-6803771 "NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P" +xref: RHEA:17417 +is_a: GO:0019200 ! carbohydrate kinase activity + +[Term] +id: GO:0045128 +name: negative regulation of reciprocal meiotic recombination +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of meiotic recombination" EXACT [] +synonym: "down-regulation of meiotic recombination" EXACT [] +synonym: "downregulation of meiotic recombination" EXACT [] +synonym: "inhibition of meiotic recombination" NARROW [] +synonym: "suppression of meiotic recombination" EXACT [] +is_a: GO:0010520 ! regulation of reciprocal meiotic recombination +is_a: GO:0045835 ! negative regulation of meiotic nuclear division +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0045129 +name: NAD-independent histone deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [PMID:28450737] +synonym: "AcuC" RELATED [] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:0045130 +name: keratan sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21] +synonym: "3'-phosphoadenylyl keratan sulfotransferase activity" RELATED [EC:2.8.2.21] +synonym: "3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity" RELATED [EC:2.8.2.21] +synonym: "3'-phosphoadenylylsulfate:keratan sulfotransferase activity" RELATED [EC:2.8.2.21] +synonym: "keratan sulfate Gal-6-sulfotransferase activity" EXACT [] +synonym: "keratan sulfate sulfotransferase activity" RELATED [EC:2.8.2.21] +synonym: "keratan sulphotransferase activity" EXACT [] +xref: EC:2.8.2.21 +xref: MetaCyc:KERATAN-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-2046175 "Further sulfation on galactose residues produces KSPG" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0045131 +name: pre-mRNA branch point binding +namespace: molecular_function +def: "Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632] +is_a: GO:0036002 ! pre-mRNA binding + +[Term] +id: GO:0045132 +name: meiotic chromosome segregation +namespace: biological_process +def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] +is_a: GO:0098813 ! nuclear chromosome segregation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0045133 +name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.14, RHEA:18477] +synonym: "2,3-dihydroxybenzoate 1,2-dioxygenase activity" RELATED [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoate oxygenase activity" RELATED [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.14] +synonym: "2,3-dihydroxybenzoic oxygenase activity" RELATED [EC:1.13.11.14] +synonym: "o-pyrocatechuate oxygenase activity" RELATED [EC:1.13.11.14] +xref: EC:1.13.11.14 +xref: KEGG_REACTION:R01507 +xref: MetaCyc:1.13.11.14-RXN +xref: RHEA:18477 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0045134 +name: uridine-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP + H2O = UMP + phosphate." [RHEA:64876] +synonym: "UDP phosphohydrolase activity" EXACT [KEGG_REACTION:R00155] +synonym: "UDPase activity" RELATED [EC:3.6.1.6] +synonym: "uridine 5'-diphosphatase activity" RELATED [EC:3.6.1.6] +synonym: "uridine diphosphatase activity" RELATED [EC:3.6.1.6] +xref: EC:3.6.1.6 +xref: KEGG_REACTION:R00155 +xref: MetaCyc:RXN-12197 +xref: RHEA:64876 +is_a: GO:0017110 ! nucleoside-diphosphatase activity + +[Term] +id: GO:0045135 +name: poly(beta-D-mannuronate) lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3] +synonym: "alginase activity" RELATED [EC:4.2.2.3] +synonym: "alginase I" RELATED [EC:4.2.2.3] +synonym: "alginate lyase activity" RELATED [EC:4.2.2.3] +synonym: "alginate lyase I activity" NARROW [EC:4.2.2.3] +synonym: "poly(beta-D-1,4-mannuronide) lyase activity" RELATED [EC:4.2.2.3] +synonym: "poly(mana) alginate lyase activity" NARROW [EC:4.2.2.3] +xref: EC:4.2.2.3 +xref: MetaCyc:4.2.2.3-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0045136 +name: development of secondary sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0003006 ! developmental process involved in reproduction + +[Term] +id: GO:0045137 +name: development of primary sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0007275 ! multicellular organism development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0045138 +name: nematode male tail tip morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome." [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314] +synonym: "male tail morphogenesis" BROAD [] +synonym: "male tail tip morphogenesis" RELATED [GOC:kmv] +synonym: "tail tip morphogenesis" RELATED [GOC:kmv] +is_a: GO:0090598 ! male anatomical structure morphogenesis + +[Term] +id: GO:0045139 +name: obsolete copper sensitivity/resistance +namespace: biological_process +def: "OBSOLETE. (Was not defined before being made obsolete)." [GOC:go_curators] +comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. +synonym: "copper sensitivity/resistance" EXACT [] +is_obsolete: true +replaced_by: GO:0046688 + +[Term] +id: GO:0045140 +name: inositol phosphoceramide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol." [PMID:9405490, PMID:9614099] +synonym: "IPC synthase activity" EXACT [] +xref: EC:2.7.1.227 +xref: MetaCyc:RXN3O-581 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0045141 +name: meiotic telomere clustering +namespace: biological_process +def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419] +synonym: "bouquet biosynthesis" NARROW [] +synonym: "bouquet formation" NARROW [] +is_a: GO:0034397 ! telomere localization +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +is_a: GO:0090220 ! chromosome localization to nuclear envelope involved in homologous chromosome segregation + +[Term] +id: GO:0045142 +name: triplex DNA binding +namespace: molecular_function +def: "Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0045143 +name: homologous chromosome segregation +namespace: biological_process +alt_id: GO:0007061 +def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] +synonym: "meiosis I, chromosome segregation" EXACT [] +is_a: GO:0045132 ! meiotic chromosome segregation +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0045144 +name: meiotic sister chromatid segregation +namespace: biological_process +def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] +synonym: "meiosis II, chromosome segregation" EXACT [] +is_a: GO:0000819 ! sister chromatid segregation +is_a: GO:0045132 ! meiotic chromosome segregation +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0045145 +name: single-stranded DNA 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101] +synonym: "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] +synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" RELATED [GOC:mah] +is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0045146 +name: initiation of acetate catabolic process by acetate +namespace: biological_process +def: "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859] +synonym: "initiation of acetate breakdown by acetate" EXACT [] +synonym: "initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0043077 ! initiation of acetate catabolic process +relationship: part_of GO:0010034 ! response to acetate + +[Term] +id: GO:0045147 +name: regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "regulation of initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:1901457 ! regulation of response to acetate +relationship: regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045148 +name: tripeptide aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide." [EC:3.4.11.4] +synonym: "alanine-phenylalanine-proline arylamidase activity" RELATED [EC:3.4.11.4] +synonym: "aminoexotripeptidase activity" RELATED [EC:3.4.11.4] +synonym: "aminotripeptidase activity" EXACT [] +synonym: "imidoendopeptidase activity" RELATED [EC:3.4.11.4] +synonym: "lymphopeptidase activity" RELATED [EC:3.4.11.4] +synonym: "peptidase B" RELATED [EC:3.4.11.4] +synonym: "peptidase T" EXACT [] +xref: EC:3.4.11.4 +xref: MetaCyc:3.4.11.4-RXN +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0034701 ! tripeptidase activity + +[Term] +id: GO:0045149 +name: acetoin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg] +synonym: "acetoin metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0045150 +name: acetoin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] +synonym: "acetoin breakdown" EXACT [] +synonym: "acetoin catabolism" EXACT [] +synonym: "acetoin degradation" EXACT [] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0045149 ! acetoin metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0045151 +name: acetoin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg] +synonym: "acetoin anabolism" EXACT [] +synonym: "acetoin biosynthesis" EXACT [] +synonym: "acetoin formation" EXACT [] +synonym: "acetoin synthesis" EXACT [] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0045149 ! acetoin metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0045152 +name: antisigma factor binding +namespace: molecular_function +def: "Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg] +synonym: "antisigma factor antagonist activity" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045155 +name: obsolete electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363] +comment: This term was obsoleted because it was not clearly defined, it has no corresponding EC or RHEA. +synonym: "cytochrome" RELATED [] +synonym: "cytochrome c" NARROW [] +is_obsolete: true + +[Term] +id: GO:0045156 +name: electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +synonym: "cytochrome bc1 complex" NARROW [] +is_a: GO:0009055 ! electron transfer activity + +[Term] +id: GO:0045157 +name: electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +is_a: GO:0009055 ! electron transfer activity + +[Term] +id: GO:0045158 +name: electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity +namespace: molecular_function +def: "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] +synonym: "cytochrome" RELATED [] +synonym: "cytochrome b/b6" RELATED [] +synonym: "cytochrome b6" NARROW [] +synonym: "cytochrome f" NARROW [] +is_a: GO:0009055 ! electron transfer activity + +[Term] +id: GO:0045159 +name: myosin II binding +namespace: molecular_function +def: "Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0045160 +name: myosin I complex +namespace: cellular_component +def: "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839] +is_a: GO:0016461 ! unconventional myosin complex + +[Term] +id: GO:0045161 +name: neuronal ion channel clustering +namespace: biological_process +def: "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0042551 ! neuron maturation + +[Term] +id: GO:0045162 +name: clustering of voltage-gated sodium channels +namespace: biological_process +def: "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440] +synonym: "clustering of voltage gated sodium channels" EXACT [] +synonym: "clustering of voltage-dependent sodium channels" EXACT [] +synonym: "Nav channel clustering" EXACT [] +synonym: "voltage-gated sodium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0045163 +name: clustering of voltage-gated potassium channels +namespace: biological_process +def: "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440] +synonym: "clustering of voltage gated potassium channels" EXACT [] +synonym: "clustering of voltage-dependent potassium channels" EXACT [] +synonym: "Kv channel clustering" EXACT [] +synonym: "voltage-gated potassium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0045164 +name: obsolete secretin (sensu Mammalia) +namespace: molecular_function +def: "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551] +comment: This term was made obsolete because it represents a gene product rather than a molecular function. +synonym: "secretin (sensu Mammalia)" EXACT [] +is_obsolete: true +consider: GO:0046659 + +[Term] +id: GO:0045165 +name: cell fate commitment +namespace: biological_process +def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] +comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0030154 ! cell differentiation + +[Term] +id: GO:0045167 +name: asymmetric protein localization involved in cell fate determination +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai] +synonym: "asymmetric protein localisation involved in cell fate determination" EXACT [GOC:mah] +synonym: "asymmetric protein localization involved in cell fate commitment" EXACT [] +synonym: "asymmetric protein localization resulting in cell fate commitment" EXACT [] +synonym: "cell fate commitment, asymmetric protein localization" EXACT [] +is_a: GO:0008104 ! protein localization +relationship: part_of GO:0001709 ! cell fate determination + +[Term] +id: GO:0045168 +name: cell-cell signaling involved in cell fate commitment +namespace: biological_process +def: "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "cell fate commitment, cell-cell signaling" EXACT [] +synonym: "cell fate commitment, cell-cell signalling" EXACT [] +synonym: "cell-cell signaling during in cell fate commitment" EXACT [] +synonym: "cell-cell signaling resulting in cell fate commitment" EXACT [] +synonym: "cell-cell signalling during cell fate commitment" EXACT [] +synonym: "cell-cell signalling involved in cell fate specification" NARROW [GOC:dph, GOC:tb] +synonym: "cell-cell signalling resulting in cell fate commitment" EXACT [] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0045165 ! cell fate commitment + +[Term] +id: GO:0045169 +name: fusome +namespace: cellular_component +def: "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045170 +name: spectrosome +namespace: cellular_component +def: "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045171 +name: intercellular bridge +namespace: cellular_component +def: "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0045172 +name: germline ring canal +namespace: cellular_component +def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] +is_a: GO:0045171 ! intercellular bridge + +[Term] +id: GO:0045173 +name: O-sialoglycoprotein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323] +synonym: "O-sialoglycoprotein breakdown" EXACT [] +synonym: "O-sialoglycoprotein catabolism" EXACT [] +synonym: "O-sialoglycoprotein degradation" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process + +[Term] +id: GO:0045174 +name: glutathione dehydrogenase (ascorbate) activity +namespace: molecular_function +def: "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [RHEA:24424] +synonym: "dehydroascorbate reductase activity" EXACT [] +synonym: "dehydroascorbic acid reductase activity" RELATED [EC:1.8.5.1] +synonym: "dehydroascorbic reductase activity" RELATED [EC:1.8.5.1] +synonym: "DHA reductase activity" RELATED [EC:1.8.5.1] +synonym: "GDOR" RELATED [EC:1.8.5.1] +synonym: "glutathione dehydroascorbate reductase activity" RELATED [EC:1.8.5.1] +synonym: "glutathione:dehydroascorbate oxidoreductase activity" RELATED [EC:1.8.5.1] +synonym: "glutathione:dehydroascorbic acid oxidoreductase activity" RELATED [EC:1.8.5.1] +xref: EC:1.8.5.1 +xref: KEGG_REACTION:R01108 +xref: MetaCyc:1.8.5.1-RXN +xref: Reactome:R-HSA-198813 "GSTO dimers reduce DeHA to AscH-" +xref: RHEA:24424 +is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0045175 +name: basal protein localization +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf] +synonym: "basal protein localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of basal protein localization" EXACT [] +synonym: "establishment and maintenance of protein localization in basal part of cell" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0045176 +name: apical protein localization +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf] +synonym: "apical protein localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of apical protein localization" EXACT [] +synonym: "establishment and maintenance of protein localization in apical part of cell" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0045177 +name: apical part of cell +namespace: cellular_component +def: "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +synonym: "apical region of cell" EXACT [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0045178 +name: basal part of cell +namespace: cellular_component +def: "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194] +subset: goslim_pir +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0045179 +name: apical cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane on the apical edge of a cell." [GOC:bf] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0045180 +name: basal cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane on the basal edge of a cell." [GOC:bf] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0045178 ! basal part of cell + +[Term] +id: GO:0045181 +name: glutamate synthase activity, NAD(P)H as acceptor +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14] +synonym: "glutamate synthase activity, NADH or NADPH as acceptor" RELATED [] +is_a: GO:0015930 ! glutamate synthase activity +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045182 +name: translation regulator activity +namespace: molecular_function +def: "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_plant +synonym: "translation factor activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0045183 +name: translation factor activity, non-nucleic acid binding +namespace: molecular_function +def: "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb] +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0045184 +name: establishment of protein localization +namespace: biological_process +def: "The directed movement of a protein to a specific location." [GOC:bf] +synonym: "establishment of protein localisation" EXACT [GOC:mah] +synonym: "protein positioning" EXACT [] +synonym: "protein recruitment" EXACT [] +is_a: GO:0008104 ! protein localization +is_a: GO:0051234 ! establishment of localization + +[Term] +id: GO:0045185 +name: maintenance of protein location +namespace: biological_process +def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] +synonym: "active protein retrieval" NARROW [] +synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] +synonym: "protein retention" NARROW [] +synonym: "protein sequestering" NARROW [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0008104 ! protein localization + +[Term] +id: GO:0045186 +name: zonula adherens assembly +namespace: biological_process +def: "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf] +is_a: GO:0034333 ! adherens junction assembly +relationship: part_of GO:0043297 ! apical junction assembly + +[Term] +id: GO:0045187 +name: regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981] +synonym: "regulation of sleep" EXACT [] +is_a: GO:0042749 ! regulation of circadian sleep/wake cycle +relationship: regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0045188 +name: regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators] +synonym: "regulation of non-REM sleep" EXACT [] +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +relationship: regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0045189 +name: obsolete connective tissue growth factor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [GOC:curators] +comment: This term was obsoleted because it represent translation of a gene product, not a specific process. +synonym: "connective tissue growth factor anabolism" EXACT [] +synonym: "connective tissue growth factor biosynthesis" EXACT [] +synonym: "connective tissue growth factor formation" EXACT [] +synonym: "connective tissue growth factor synthesis" EXACT [] +synonym: "CTGF biosynthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045190 +name: isotype switching +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149] +comment: Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'. +synonym: "class switch recombination" EXACT [] +synonym: "class switching" EXACT [] +synonym: "isotype switch recombination" EXACT [] +xref: Wikipedia:Immunoglobulin_class_switching +is_a: GO:0002204 ! somatic recombination of immunoglobulin genes involved in immune response +is_a: GO:0002312 ! B cell activation involved in immune response + +[Term] +id: GO:0045191 +name: regulation of isotype switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching." [GOC:ai] +synonym: "regulation of class switch recombination" EXACT [] +synonym: "regulation of class switching" EXACT [] +synonym: "regulation of isotype switch recombination" EXACT [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +is_a: GO:0050864 ! regulation of B cell activation +relationship: regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045192 +name: obsolete low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "LDL catabolic process" EXACT [] +synonym: "LDL catabolism" EXACT [] +synonym: "low-density lipoprotein breakdown" EXACT [] +synonym: "low-density lipoprotein catabolic process" EXACT [] +synonym: "low-density lipoprotein catabolism" EXACT [] +synonym: "low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045193 +name: obsolete acetylated low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "Ac-LDL catabolic process" EXACT [] +synonym: "Ac-LDL catabolism" EXACT [] +synonym: "acetylated low-density lipoprotein breakdown" EXACT [] +synonym: "acetylated low-density lipoprotein catabolic process" EXACT [] +synonym: "acetylated low-density lipoprotein catabolism" EXACT [] +synonym: "acetylated low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045194 +name: obsolete oxidized low-density lipoprotein catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators] +comment: This term was made obsolete because low-density lipoprotein is a macromolecular complex, not a single class of molecule; its degradation involves the dissociation of non-covalently attached constituents as well as some breaking and reforming of covalent bonds. +synonym: "Ox-LDL catabolic process" EXACT [] +synonym: "Ox-LDL catabolism" EXACT [] +synonym: "oxidized low-density lipoprotein breakdown" EXACT [] +synonym: "oxidized low-density lipoprotein catabolic process" EXACT [] +synonym: "oxidized low-density lipoprotein catabolism" EXACT [] +synonym: "oxidized low-density lipoprotein degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045195 +name: obsolete gallstone formation +namespace: biological_process +def: "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm] +comment: This term was made obsolete because the process it represents is pathological. +synonym: "gallstone formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045196 +name: establishment or maintenance of neuroblast polarity +namespace: biological_process +alt_id: GO:0043339 +alt_id: GO:0043342 +def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083] +synonym: "establishment and/or maintenance of neuroblast cell polarity" EXACT [] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +relationship: part_of GO:0055059 ! asymmetric neuroblast division + +[Term] +id: GO:0045197 +name: establishment or maintenance of epithelial cell apical/basal polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah] +is_a: GO:0035088 ! establishment or maintenance of apical/basal cell polarity + +[Term] +id: GO:0045198 +name: establishment of epithelial cell apical/basal polarity +namespace: biological_process +def: "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] +is_a: GO:0030859 ! polarized epithelial cell differentiation +is_a: GO:0035089 ! establishment of apical/basal cell polarity +is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity +is_a: GO:0090162 ! establishment of epithelial cell polarity + +[Term] +id: GO:0045199 +name: maintenance of epithelial cell apical/basal polarity +namespace: biological_process +def: "The maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf] +is_a: GO:0035090 ! maintenance of apical/basal cell polarity +is_a: GO:0045197 ! establishment or maintenance of epithelial cell apical/basal polarity + +[Term] +id: GO:0045200 +name: establishment of neuroblast polarity +namespace: biological_process +alt_id: GO:0043340 +alt_id: GO:0043343 +def: "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] +synonym: "establishment of neuroblast cell polarity" EXACT [] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity + +[Term] +id: GO:0045201 +name: maintenance of neuroblast polarity +namespace: biological_process +alt_id: GO:0043341 +alt_id: GO:0043344 +def: "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu] +synonym: "maintenance of neuroblast cell polarity" EXACT [] +is_a: GO:0030011 ! maintenance of cell polarity +is_a: GO:0045196 ! establishment or maintenance of neuroblast polarity + +[Term] +id: GO:0045202 +name: synapse +namespace: cellular_component +def: "The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] +subset: goslim_agr +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +subset: goslim_synapse +synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] +synonym: "mixed synapse" NARROW [NIF_Subcellular:sao1506103497] +synonym: "synaptic junction" EXACT [] +xref: NIF_Subcellular:sao914572699 +xref: Wikipedia:Chemical_synapse +is_a: GO:0030054 ! cell junction + +[Term] +id: GO:0045203 +name: integral component of cell outer membrane +namespace: cellular_component +def: "The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators, GOC:mtg_sensu] +synonym: "integral to cell outer membrane" NARROW [] +synonym: "integral to external membrane" RELATED [] +synonym: "integral to outer membrane" RELATED [] +is_a: GO:0016021 ! integral component of membrane +is_a: GO:0031230 ! intrinsic component of cell outer membrane + +[Term] +id: GO:0045204 +name: MAPK export from nucleus +namespace: biological_process +def: "The directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "cytoplasmic translocation of MAP kinase" EXACT [] +synonym: "cytoplasmic translocation of mitogen-activated protein kinase" EXACT [] +synonym: "MAPK export from cell nucleus" EXACT [] +synonym: "MAPK export out of nucleus" EXACT [] +synonym: "MAPK transport from nucleus to cytoplasm" EXACT [] +synonym: "MAPK-nucleus export" EXACT [] +is_a: GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0045205 +name: obsolete MAPK transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because we do not know what it was intended to represent when it was created. +synonym: "MAPK transporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045206 +name: obsolete MAPK phosphatase transporter activity +namespace: molecular_function +alt_id: GO:0045207 +def: "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729] +comment: This term was made obsolete because we do not know what it was intended to represent when it was created. +synonym: "leptomycin B-sensitive MAPK phosphatase transporter activity" NARROW [] +synonym: "leptomycin B-sensitive MKP shuttle" NARROW [] +synonym: "MAPK phosphatase transporter activity" EXACT [] +synonym: "MKP shuttle" NARROW [] +is_obsolete: true + +[Term] +id: GO:0045208 +name: MAPK phosphatase export from nucleus +namespace: biological_process +def: "The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "MAPK phosphatase export from cell nucleus" EXACT [] +synonym: "MAPK phosphatase export out of nucleus" EXACT [] +synonym: "MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] +synonym: "MAPK phosphatase-nucleus export" EXACT [] +is_a: GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0045209 +name: MAPK phosphatase export from nucleus, leptomycin B sensitive +namespace: biological_process +def: "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc] +synonym: "leptomycin B-sensitive MAPK phosphatase export out of nucleus" EXACT [] +synonym: "leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm" EXACT [] +synonym: "leptomycin B-sensitive MAPK phosphatase-nucleus export" EXACT [] +synonym: "MAPK phosphatase export from cell nucleus, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase export out of nucleus, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive" EXACT [] +synonym: "MAPK phosphatase-nucleus export, leptomycin B sensitive" EXACT [] +is_a: GO:0045208 ! MAPK phosphatase export from nucleus + +[Term] +id: GO:0045210 +name: FasL biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/] +synonym: "APT1LG1 biosynthetic process" EXACT [GOC:add] +synonym: "CD178 biosynthetic process" EXACT [GOC:add] +synonym: "CD95L biosynthesis" EXACT [GOC:add] +synonym: "CD95L biosynthetic process" EXACT [GOC:add] +synonym: "fas ligand biosynthetic process" EXACT [GOC:add, PR:000000095] +synonym: "Fas-L biosynthetic process" EXACT [GOC:add] +synonym: "FasL anabolism" EXACT [] +synonym: "FasL biosynthesis" EXACT [] +synonym: "FasL formation" EXACT [] +synonym: "FasL synthesis" EXACT [] +synonym: "FASLG biosynthetic process" EXACT [GOC:add] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0045211 +name: postsynaptic membrane +namespace: cellular_component +def: "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732] +subset: goslim_synapse +synonym: "post-synaptic membrane" EXACT [] +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0045212 +name: obsolete neurotransmitter receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "neurotransmitter receptor anabolism" EXACT [] +synonym: "neurotransmitter receptor biosynthesis" EXACT [] +synonym: "neurotransmitter receptor formation" EXACT [] +synonym: "neurotransmitter receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045213 +name: neurotransmitter receptor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neurotransmitter receptors." [GOC:go_curators] +synonym: "neurotransmitter receptor metabolism" EXACT [] +is_a: GO:0043112 ! receptor metabolic process + +[Term] +id: GO:0045214 +name: sarcomere organization +namespace: biological_process +alt_id: GO:0006938 +def: "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf] +synonym: "sarcomere alignment" EXACT [] +synonym: "sarcomere organisation" EXACT [] +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0045216 +name: cell-cell junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "cell-cell junction assembly and maintenance" EXACT [] +synonym: "cell-cell junction biogenesis" RELATED [] +synonym: "cell-cell junction organisation" EXACT [GOC:mah] +synonym: "intercellular junction assembly and maintenance" EXACT [] +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0045217 +name: cell-cell junction maintenance +namespace: biological_process +def: "The maintenance of junctions between cells." [GOC:ai] +synonym: "intercellular junction maintenance" EXACT [] +is_a: GO:0034331 ! cell junction maintenance +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0045218 +name: zonula adherens maintenance +namespace: biological_process +def: "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf] +is_a: GO:0034334 ! adherens junction maintenance + +[Term] +id: GO:0045219 +name: regulation of FasL production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "regulation of FasL anabolism" EXACT [] +synonym: "regulation of FasL biosynthesis" EXACT [] +synonym: "regulation of FasL formation" EXACT [] +synonym: "regulation of FasL synthesis" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045220 +name: positive regulation of FasL production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "activation of FasL biosynthetic process" NARROW [] +synonym: "positive regulation of FasL anabolism" EXACT [] +synonym: "positive regulation of FasL biosynthesis" EXACT [] +synonym: "positive regulation of FasL biosynthetic process" EXACT [] +synonym: "positive regulation of FasL formation" EXACT [] +synonym: "positive regulation of FasL synthesis" EXACT [] +synonym: "stimulation of FasL biosynthetic process" NARROW [] +synonym: "up regulation of FasL biosynthetic process" EXACT [] +synonym: "up-regulation of FasL biosynthetic process" EXACT [] +synonym: "upregulation of FasL biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0045219 ! regulation of FasL production +relationship: positively_regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045221 +name: negative regulation of FasL production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators] +synonym: "down regulation of FasL biosynthetic process" EXACT [] +synonym: "down-regulation of FasL biosynthetic process" EXACT [] +synonym: "downregulation of FasL biosynthetic process" EXACT [] +synonym: "inhibition of FasL biosynthetic process" NARROW [] +synonym: "negative regulation of FasL anabolism" EXACT [] +synonym: "negative regulation of FasL biosynthesis" EXACT [] +synonym: "negative regulation of FasL biosynthetic process" EXACT [] +synonym: "negative regulation of FasL formation" EXACT [] +synonym: "negative regulation of FasL synthesis" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0045219 ! regulation of FasL production +relationship: negatively_regulates GO:0045210 ! FasL biosynthetic process + +[Term] +id: GO:0045222 +name: CD4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732] +synonym: "CD4 anabolism" EXACT [] +synonym: "CD4 biosynthesis" EXACT [] +synonym: "CD4 formation" EXACT [] +synonym: "CD4 synthesis" EXACT [] +is_a: GO:0009101 ! glycoprotein biosynthetic process + +[Term] +id: GO:0045223 +name: regulation of CD4 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "regulation of CD4 anabolism" EXACT [] +synonym: "regulation of CD4 biosynthesis" EXACT [] +synonym: "regulation of CD4 biosynthetic process" EXACT [] +synonym: "regulation of CD4 formation" EXACT [] +synonym: "regulation of CD4 synthesis" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045224 +name: positive regulation of CD4 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "activation of CD4 biosynthetic process" NARROW [] +synonym: "positive regulation of CD4 anabolism" EXACT [] +synonym: "positive regulation of CD4 biosynthesis" EXACT [] +synonym: "positive regulation of CD4 biosynthetic process" EXACT [] +synonym: "positive regulation of CD4 formation" EXACT [] +synonym: "positive regulation of CD4 synthesis" EXACT [] +synonym: "stimulation of CD4 biosynthetic process" NARROW [] +synonym: "up regulation of CD4 biosynthetic process" EXACT [] +synonym: "up-regulation of CD4 biosynthetic process" EXACT [] +synonym: "upregulation of CD4 biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0045223 ! regulation of CD4 production +relationship: positively_regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045225 +name: negative regulation of CD4 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators] +synonym: "down regulation of CD4 biosynthetic process" EXACT [] +synonym: "down-regulation of CD4 biosynthetic process" EXACT [] +synonym: "downregulation of CD4 biosynthetic process" EXACT [] +synonym: "inhibition of CD4 biosynthetic process" NARROW [] +synonym: "negative regulation of CD4 anabolism" EXACT [] +synonym: "negative regulation of CD4 biosynthesis" EXACT [] +synonym: "negative regulation of CD4 biosynthetic process" EXACT [] +synonym: "negative regulation of CD4 formation" EXACT [] +synonym: "negative regulation of CD4 synthesis" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0045223 ! regulation of CD4 production +relationship: negatively_regulates GO:0045222 ! CD4 biosynthetic process + +[Term] +id: GO:0045226 +name: extracellular polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators] +synonym: "extracellular polysaccharide anabolism" EXACT [] +synonym: "extracellular polysaccharide biosynthesis" EXACT [] +synonym: "extracellular polysaccharide formation" EXACT [] +synonym: "extracellular polysaccharide synthesis" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0046379 ! extracellular polysaccharide metabolic process + +[Term] +id: GO:0045227 +name: capsule polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators] +synonym: "capsular polysaccharide biosynthesis" EXACT [] +synonym: "capsular polysaccharide biosynthetic process" EXACT [] +synonym: "capsule polysaccharide anabolism" EXACT [] +synonym: "capsule polysaccharide biosynthesis" EXACT [] +synonym: "capsule polysaccharide formation" EXACT [] +synonym: "capsule polysaccharide synthesis" EXACT [] +is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process +is_a: GO:0045230 ! capsule organization + +[Term] +id: GO:0045228 +name: slime layer polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators] +synonym: "slime layer polysaccharide anabolism" EXACT [] +synonym: "slime layer polysaccharide biosynthesis" EXACT [] +synonym: "slime layer polysaccharide formation" EXACT [] +synonym: "slime layer polysaccharide synthesis" EXACT [] +is_a: GO:0045226 ! extracellular polysaccharide biosynthetic process +is_a: GO:0045231 ! slime layer organization + +[Term] +id: GO:0045229 +name: external encapsulating structure organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "external encapsulating structure organisation" EXACT [] +synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0045230 +name: capsule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] +subset: goslim_pir +synonym: "capsule organisation" EXACT [] +synonym: "capsule organization and biogenesis" RELATED [] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045231 +name: slime layer organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai] +subset: goslim_pir +synonym: "slime layer organisation" EXACT [] +synonym: "slime layer organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045232 +name: S-layer organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai] +synonym: "S-layer organisation" EXACT [] +synonym: "S-layer organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0045233 +name: obsolete natural killer cell receptor activity +namespace: molecular_function +def: "OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc] +comment: This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity. +synonym: "Ly49i" NARROW [] +synonym: "natural killer cell receptor activity" EXACT [] +synonym: "NK cell receptor activity" EXACT [] +is_obsolete: true +consider: GO:0002769 +consider: GO:0004888 +consider: GO:0030101 + +[Term] +id: GO:0045234 +name: protein palmitoleylation +namespace: biological_process +alt_id: GO:0045235 +def: "The covalent attachment of a palmitoleyl group to a protein." [GOC:ai] +synonym: "protein amino acid palmitoleylation" EXACT [GOC:bf] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0045236 +name: CXCR chemokine receptor binding +namespace: molecular_function +def: "Binding to a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892] +synonym: "alpha chemokine receptor binding" EXACT [] +synonym: "alpha chemokine receptor ligand" NARROW [] +synonym: "C-X-C chemokine receptor ligand" NARROW [] +synonym: "CXC chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0045237 +name: CXCR1 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892] +synonym: "CXCR1 chemokine receptor ligand" NARROW [] +is_a: GO:0005153 ! interleukin-8 receptor binding + +[Term] +id: GO:0045238 +name: CXCR2 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892] +synonym: "CXCR2 chemokine receptor ligand" NARROW [] +is_a: GO:0005153 ! interleukin-8 receptor binding + +[Term] +id: GO:0045239 +name: tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes that act in the TCA cycle." [GOC:mah] +subset: goslim_pir +synonym: "TCA cycle enzyme complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045240 +name: dihydrolipoyl dehydrogenase complex +namespace: cellular_component +def: "A protein complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah] +synonym: "2-oxoglutarate dehydrogenase complex" EXACT [] +synonym: "alpha-ketoglutarate dehydrogenase complex" EXACT [] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0045241 +name: cytosolic alpha-ketoglutarate dehydrogenase complex +namespace: cellular_component +def: "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] +synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] +is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex +is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045242 +name: isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0045243 +name: cytosolic isocitrate dehydrogenase complex (NAD+) +namespace: cellular_component +def: "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] +synonym: "isocitrate dehydrogenase complex (NAD+)" BROAD [] +is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) +is_a: GO:0045246 ! cytosolic tricarboxylic acid cycle enzyme complex + +[Term] +id: GO:0045244 +name: succinate-CoA ligase complex (GDP-forming) +namespace: cellular_component +alt_id: GO:0008325 +alt_id: GO:0045245 +def: "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [GOC:jl, PMID:27487822] +synonym: "succinyl-CoA synthetase, GDP-forming" EXACT [CORUM:392] +is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex +is_a: GO:0042709 ! succinate-CoA ligase complex + +[Term] +id: GO:0045246 +name: cytosolic tricarboxylic acid cycle enzyme complex +namespace: cellular_component +def: "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] +synonym: "TCA cycle enzyme complex" BROAD [] +synonym: "tricarboxylic acid cycle enzyme complex" BROAD [] +is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0045247 +name: cytosolic electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732] +is_a: GO:0045251 ! electron transfer flavoprotein complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0045248 +name: cytosolic oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975] +is_a: GO:0045252 ! oxoglutarate dehydrogenase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0045249 +name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502] +comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. +is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0045250 +name: cytosolic pyruvate dehydrogenase complex +namespace: cellular_component +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +synonym: "pyruvate dehydrogenase complex (lipoamide)" RELATED [] +is_a: GO:0045254 ! pyruvate dehydrogenase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0045251 +name: electron transfer flavoprotein complex +namespace: cellular_component +def: "A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system." [GOC:bhm, ISBN:0198506732] +subset: goslim_pir +synonym: "ETF complex" EXACT [GOC:bhm] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045252 +name: oxoglutarate dehydrogenase complex +namespace: cellular_component +def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975] +subset: goslim_pir +synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] +is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0045253 +name: pyruvate dehydrogenase (lipoamide) phosphatase complex +namespace: cellular_component +def: "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502] +comment: See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. +subset: goslim_pir +is_a: GO:1903293 ! phosphatase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045254 +name: pyruvate dehydrogenase complex +namespace: cellular_component +alt_id: GO:0009364 +def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. +subset: goslim_pir +synonym: "dihydrolipoyl dehydrogenase complex" BROAD [] +synonym: "pyruvate dehydrogenase complex (lipoamide)" EXACT [] +xref: Wikipedia:Pyruvate_dehydrogenase_complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0045257 +name: succinate dehydrogenase complex (ubiquinone) +namespace: cellular_component +def: "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684] +is_a: GO:0045281 ! succinate dehydrogenase complex + +[Term] +id: GO:0045258 +name: plasma membrane succinate dehydrogenase complex (ubiquinone) +namespace: cellular_component +def: "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684] +is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) +is_a: GO:0045282 ! plasma membrane succinate dehydrogenase complex + +[Term] +id: GO:0045259 +name: proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0045255 +def: "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [ISBN:0198547684, ISBN:0716743663] +synonym: "F1-F0 complex" EXACT [] +synonym: "hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "hydrogen-transporting ATP synthase complex" EXACT [] +synonym: "proton-transporting F-type ATPase complex" RELATED [] +is_a: GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:0045260 +name: plasma membrane proton-transporting ATP synthase complex +namespace: cellular_component +alt_id: GO:0045256 +def: "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684] +synonym: "hydrogen-translocating F-type ATPase complex" BROAD [] +synonym: "hydrogen-transporting ATP synthase" EXACT [] +synonym: "plasma membrane hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "proton-transporting ATP synthase complex" BROAD [] +is_a: GO:0045259 ! proton-transporting ATP synthase complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0045261 +name: proton-transporting ATP synthase complex, catalytic core F(1) +namespace: cellular_component +def: "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, F1 sector" EXACT [] +is_a: GO:0033178 ! proton-transporting two-sector ATPase complex, catalytic domain +relationship: part_of GO:0005622 ! intracellular anatomical structure +relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex + +[Term] +id: GO:0045262 +name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) +namespace: cellular_component +def: "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056] +comment: See also the cellular component term 'plasma membrane ; GO:0005886'. +synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] +synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] +is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex + +[Term] +id: GO:0045263 +name: proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056] +synonym: "hydrogen-transporting ATP synthase complex, coupling factor F(o)" EXACT [GOC:mah] +synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" NARROW [] +synonym: "hydrogen-transporting ATP synthase, F0 sector" EXACT [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" EXACT [] +is_a: GO:0033177 ! proton-transporting two-sector ATPase complex, proton-transporting domain +relationship: part_of GO:0005622 ! intracellular anatomical structure +relationship: part_of GO:0045259 ! proton-transporting ATP synthase complex + +[Term] +id: GO:0045264 +name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) +namespace: cellular_component +def: "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, F0 sector" BROAD [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(0)" BROAD [] +synonym: "proton-transporting ATP synthase complex, coupling factor F(o)" BROAD [] +is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045260 ! plasma membrane proton-transporting ATP synthase complex + +[Term] +id: GO:0045265 +name: proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, stator stalk" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0045266 +name: plasma membrane proton-transporting ATP synthase, stator stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, stator stalk" BROAD [] +synonym: "proton-transporting ATP synthase, stator stalk" BROAD [] +is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045264 ! plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) + +[Term] +id: GO:0045267 +name: proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, catalytic core" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045268 +name: plasma membrane proton-transporting ATP synthase, catalytic core +namespace: cellular_component +def: "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, catalytic core" BROAD [] +synonym: "proton-transporting ATP synthase, catalytic core" BROAD [] +is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045269 +name: proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, central stalk" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045270 +name: plasma membrane proton-transporting ATP synthase, central stalk +namespace: cellular_component +def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056] +synonym: "hydrogen-transporting ATP synthase, central stalk" BROAD [] +synonym: "proton-transporting ATP synthase, central stalk" BROAD [] +is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045262 ! plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) + +[Term] +id: GO:0045271 +name: respiratory chain complex I +namespace: cellular_component +alt_id: GO:0045279 +def: "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556] +comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. +synonym: "electron transport complex I" RELATED [] +synonym: "NADH dehydrogenase (ubiquinone) complex" EXACT [] +synonym: "NADH dehydrogenase complex (ubiquinone)" EXACT [] +synonym: "NADH-Q oxidoreductase complex" EXACT [] +is_a: GO:0030964 ! NADH dehydrogenase complex +is_a: GO:0098803 ! respiratory chain complex +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:0045272 +name: plasma membrane respiratory chain complex I +namespace: cellular_component +def: "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "NADH dehydrogenase (ubiquinone) complex" BROAD [] +synonym: "respiratory chain complex I" BROAD [] +is_a: GO:0045271 ! respiratory chain complex I +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0070470 ! plasma membrane respirasome + +[Term] +id: GO:0045273 +name: respiratory chain complex II +namespace: cellular_component +def: "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684] +subset: goslim_pir +synonym: "electron transport complex II" RELATED [] +is_a: GO:0098803 ! respiratory chain complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0045274 +name: plasma membrane respiratory chain complex II +namespace: cellular_component +def: "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "respiratory chain complex II" BROAD [] +is_a: GO:0045273 ! respiratory chain complex II +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0070470 ! plasma membrane respirasome + +[Term] +id: GO:0045275 +name: respiratory chain complex III +namespace: cellular_component +alt_id: GO:0032842 +alt_id: GO:0045285 +def: "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733] +subset: goslim_pir +synonym: "coenzyme Q-cytochrome c oxidoreductase complex" RELATED [] +synonym: "coenzyme Q-cytochrome c reductase complex" RELATED [] +synonym: "complex III" EXACT [] +synonym: "CoQH2-cytochrome c reductase complex" RELATED [] +synonym: "cytochrome bc(1) complex" EXACT [] +synonym: "cytochrome bc1 complex" EXACT [] +synonym: "electron transport complex III" RELATED [] +synonym: "ubiquinol-cytochrome c oxidoreductase complex" EXACT [] +synonym: "ubiquinol-cytochrome-c reductase complex" EXACT [] +xref: Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase +is_a: GO:0070069 ! cytochrome complex +is_a: GO:0098803 ! respiratory chain complex +is_a: GO:1902495 ! transmembrane transporter complex +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0045276 +name: plasma membrane respiratory chain complex III +namespace: cellular_component +alt_id: GO:0045286 +def: "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "plasma membrane coenzyme Q-cytochrome c oxidoreductase complex" EXACT [] +synonym: "plasma membrane coenzyme Q-cytochrome c reductase complex" EXACT [] +synonym: "plasma membrane cytochrome bc1 complex" EXACT [] +synonym: "plasma membrane ubiquinol-cytochrome-c reductase complex" EXACT [] +synonym: "respiratory chain complex III" BROAD [] +synonym: "ubiquinol-cytochrome c oxidoreductase complex" BROAD [] +synonym: "ubiquinol-cytochrome-c reductase complex" BROAD [] +is_a: GO:0045275 ! respiratory chain complex III +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0070470 ! plasma membrane respirasome + +[Term] +id: GO:0045277 +name: respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0045287 +def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] +subset: goslim_pir +synonym: "cytochrome c oxidase complex" EXACT [] +synonym: "electron transport complex IV" RELATED [] +is_a: GO:0070069 ! cytochrome complex +is_a: GO:0098803 ! respiratory chain complex + +[Term] +id: GO:0045278 +name: plasma membrane respiratory chain complex IV +namespace: cellular_component +alt_id: GO:0045288 +def: "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684] +synonym: "cytochrome c oxidase complex" BROAD [] +synonym: "respiratory chain complex IV" BROAD [] +is_a: GO:0045277 ! respiratory chain complex IV +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0070470 ! plasma membrane respirasome + +[Term] +id: GO:0045281 +name: succinate dehydrogenase complex +namespace: cellular_component +def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701] +is_a: GO:0098803 ! respiratory chain complex +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0045273 ! respiratory chain complex II + +[Term] +id: GO:0045282 +name: plasma membrane succinate dehydrogenase complex +namespace: cellular_component +def: "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701] +synonym: "succinate dehydrogenase complex" BROAD [] +is_a: GO:0045281 ! succinate dehydrogenase complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II + +[Term] +id: GO:0045283 +name: fumarate reductase complex +namespace: cellular_component +def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224] +comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. +is_a: GO:0098803 ! respiratory chain complex +relationship: part_of GO:0045273 ! respiratory chain complex II + +[Term] +id: GO:0045284 +name: plasma membrane fumarate reductase complex +namespace: cellular_component +def: "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224] +comment: See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. +synonym: "fumarate reductase complex" BROAD [] +is_a: GO:0045283 ! fumarate reductase complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0045274 ! plasma membrane respiratory chain complex II + +[Term] +id: GO:0045289 +name: luciferin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf] +synonym: "luciferase activity" EXACT [] +synonym: "luciferase monooxygenase activity" RELATED [] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0045290 +name: D-arabinose 1-dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117] +synonym: "D-arabinose:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.117] +xref: EC:1.1.1.117 +xref: MetaCyc:1.1.1.117-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045291 +name: mRNA trans splicing, SL addition +namespace: biological_process +def: "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423] +synonym: "nuclear mRNA trans splicing, SL addition" EXACT [GOC:vw] +synonym: "nuclear mRNA trans splicing, spliced leader addition" EXACT [] +is_a: GO:0000365 ! mRNA trans splicing, via spliceosome + +[Term] +id: GO:0045292 +name: mRNA cis splicing, via spliceosome +namespace: biological_process +def: "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, ISBN:0879695897, PMID:18458335] +synonym: "nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:vw] +synonym: "nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [] +synonym: "splicing" BROAD [GOC:vw] +is_a: GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0045293 +name: mRNA editing complex +namespace: cellular_component +def: "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607, PMID:24316715] +subset: goslim_pir +synonym: "editosome" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0045294 +name: alpha-catenin binding +namespace: molecular_function +def: "Binding to catenin complex alpha subunit." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045295 +name: gamma-catenin binding +namespace: molecular_function +def: "Binding to catenin complex gamma subunit." [GOC:bf] +synonym: "plakoglobin binding" EXACT [GOC:BHF] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045296 +name: cadherin binding +namespace: molecular_function +def: "Binding to cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf] +is_a: GO:0050839 ! cell adhesion molecule binding + +[Term] +id: GO:0045297 +name: obsolete post-mating behavior +namespace: biological_process +def: "OBSOLETE. The specific behavior of an organism following mating." [GOC:bf, GOC:pr] +comment: This term was obsoleted because it was not precisely defined. +synonym: "post-mating behaviour" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045298 +name: tubulin complex +namespace: cellular_component +def: "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0045299 +name: otolith mineralization +namespace: biological_process +def: "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] +is_a: GO:0031214 ! biomineral tissue development +relationship: part_of GO:0048840 ! otolith development + +[Term] +id: GO:0045300 +name: acyl-[acyl-carrier-protein] desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2] +comment: Note that this function was formerly EC:1.14.99.6. +synonym: "acyl-[acyl-carrier protein] desaturase activity" EXACT [] +synonym: "acyl-acyl-carrier-protein desaturase activity" RELATED [EC:1.14.19.2] +synonym: "acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.19.2] +synonym: "stearyl acyl carrier protein desaturase activity" RELATED [EC:1.14.19.2] +synonym: "stearyl-ACP desaturase activity" RELATED [EC:1.14.19.2] +xref: EC:1.14.19.2 +xref: MetaCyc:1.14.19.2-RXN +xref: MetaCyc:PWY-5147 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0045301 +name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666] +synonym: "2-methylthio-cis-ribozeatin hydroxylase activity" EXACT [] +synonym: "tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity" EXACT [] +synonym: "tRNA-(ms2io6A)-hydroxylase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0045302 +name: choloylglycine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity" RELATED [EC:3.5.1.24] +synonym: "bile salt hydrolase activity" RELATED [EC:3.5.1.24] +synonym: "choloyltaurine hydrolase activity" RELATED [EC:3.5.1.24] +synonym: "glycocholase activity" RELATED [EC:3.5.1.24] +xref: EC:3.5.1.24 +xref: MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN +xref: RHEA:19353 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0045303 +name: diaminobutyrate-2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11160] +synonym: "2,4-diaminobutyrate 4-aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "DAB aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "DABA aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "diaminibutyric acid aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "diaminobutyrate transaminase activity" RELATED [EC:2.6.1.76] +synonym: "diaminobutyrate--2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "EctB" RELATED [EC:2.6.1.76] +synonym: "L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76] +synonym: "L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity" RELATED [EC:2.6.1.76] +xref: EC:2.6.1.76 +xref: KEGG_REACTION:R06977 +xref: MetaCyc:R101-RXN +xref: RHEA:11160 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0045304 +name: regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg] +synonym: "regulator of establishment of competence for transformation activity" RELATED [] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032104 ! regulation of response to extracellular stimulus +relationship: regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045305 +name: obsolete regulator of establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +synonym: "regulator of establishment of competence for transformation activity" EXACT [] +is_obsolete: true +replaced_by: GO:0045304 + +[Term] +id: GO:0045306 +name: obsolete inhibitor of the establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Inhibits the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +synonym: "inhibitor of the establishment of competence for transformation activity" EXACT [] +is_obsolete: true +replaced_by: GO:0045808 + +[Term] +id: GO:0045307 +name: obsolete activator of the establishment of competence for transformation activity +namespace: molecular_function +def: "OBSOLETE. Activates the establishment of competence for transformation." [GOC:mlg] +comment: This term was made obsolete because it does not represent a true function. +synonym: "activator of the establishment of competence for transformation activity" EXACT [] +is_obsolete: true +replaced_by: GO:0045809 + +[Term] +id: GO:0045309 +name: protein phosphorylated amino acid binding +namespace: molecular_function +def: "Binding to a phosphorylated amino acid residue within a protein." [GOC:go_curators] +synonym: "phosphoprotein amino acid binding" RELATED [] +is_a: GO:0051219 ! phosphoprotein binding + +[Term] +id: GO:0045310 +name: obsolete phosphoserine/phosphothreonine binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators] +comment: This term was made obsolete because it represents two functions. +synonym: "phosphoserine/phosphothreonine binding" EXACT [] +is_obsolete: true +consider: GO:0050815 +consider: GO:0050816 + +[Term] +id: GO:0045311 +name: invasive growth in response to pheromone +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc] +is_a: GO:0036267 ! invasive filamentous growth +relationship: part_of GO:0019236 ! response to pheromone + +[Term] +id: GO:0045312 +name: nor-spermidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators] +synonym: "nor-spermidine anabolism" EXACT [] +synonym: "nor-spermidine biosynthesis" EXACT [] +synonym: "nor-spermidine formation" EXACT [] +synonym: "nor-spermidine synthesis" EXACT [] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:0046204 ! nor-spermidine metabolic process + +[Term] +id: GO:0045313 +name: rhabdomere membrane biogenesis +namespace: biological_process +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl] +is_a: GO:0044091 ! membrane biogenesis +relationship: part_of GO:0042052 ! rhabdomere development + +[Term] +id: GO:0045314 +name: regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "regulation of eye photoreceptor development" BROAD [] +is_a: GO:0042478 ! regulation of eye photoreceptor cell development +relationship: part_of GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045315 +name: positive regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "activation of eye photoreceptor development" BROAD [] +synonym: "positive regulation of eye photoreceptor development" BROAD [] +synonym: "stimulation of eye photoreceptor development" BROAD [] +synonym: "up regulation of eye photoreceptor development" BROAD [] +synonym: "up-regulation of eye photoreceptor development" BROAD [] +synonym: "upregulation of eye photoreceptor development" BROAD [] +is_a: GO:0042479 ! positive regulation of eye photoreceptor cell development +is_a: GO:0045314 ! regulation of compound eye photoreceptor development +relationship: positively_regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045316 +name: negative regulation of compound eye photoreceptor development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf] +synonym: "down regulation of eye photoreceptor development" BROAD [] +synonym: "down-regulation of eye photoreceptor development" BROAD [] +synonym: "downregulation of eye photoreceptor development" BROAD [] +synonym: "inhibition of eye photoreceptor development" BROAD [] +synonym: "negative regulation of eye photoreceptor development" BROAD [] +is_a: GO:0042480 ! negative regulation of eye photoreceptor cell development +is_a: GO:0045314 ! regulation of compound eye photoreceptor development +relationship: negatively_regulates GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045317 +name: equator specification +namespace: biological_process +def: "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity + +[Term] +id: GO:0045319 +name: obsolete SRP-independent cotranslational protein-membrane targeting, translocation +namespace: biological_process +def: "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai] +comment: This term was made obsolete because there is no evidence for the existence of this process. +synonym: "SRP-independent cotranslational membrane targeting, translocation" EXACT [] +synonym: "SRP-independent cotranslational protein-membrane targeting, translocation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045320 +name: chloroplast proton-transporting ATP synthase complex +namespace: cellular_component +def: "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663] +synonym: "chloroplast hydrogen-translocating F-type ATPase complex" EXACT [] +synonym: "chloroplast proton-transporting F-type ATPase complex" EXACT [] +synonym: "hydrogen-translocating F-type ATPase complex" BROAD [] +is_a: GO:0045259 ! proton-transporting ATP synthase complex +is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex + +[Term] +id: GO:0045321 +name: leukocyte activation +namespace: biological_process +def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add] +synonym: "immune cell activation" EXACT [] +synonym: "leucocyte activation" EXACT [] +xref: Wikipedia:Immunologic_activation +is_a: GO:0001775 ! cell activation +is_a: GO:0002376 ! immune system process + +[Term] +id: GO:0045322 +name: unmethylated CpG binding +namespace: molecular_function +def: "Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657] +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0045323 +name: interleukin-1 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075] +synonym: "IL-1 receptor complex" EXACT [GOC:add] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0045324 +name: late endosome to vacuole transport +namespace: biological_process +def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141] +is_a: GO:0007034 ! vacuolar transport +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0045325 +name: peptidyl-tryptophan hydroxylation +namespace: biological_process +def: "The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan." [RESID:AA0322] +xref: RESID:AA0322 +is_a: GO:0018211 ! peptidyl-tryptophan modification + +[Term] +id: GO:0045326 +name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323] +synonym: "DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine" EXACT [GOC:mah] +xref: RESID:AA0323 +is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine + +[Term] +id: GO:0045327 +name: protein-DNA covalent cross-linking via peptidyl-tyrosine +namespace: biological_process +def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue." [GOC:jsg] +synonym: "DNA-protein covalent cross-linking via peptidyl-tyrosine" EXACT [GOC:mah] +is_a: GO:0018142 ! protein-DNA covalent cross-linking +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0045328 +name: cytochrome P450 4A1-heme linkage +namespace: biological_process +def: "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [GOC:cjm, RESID:AA0324] +synonym: "cytochrome P450 4A1-haem linkage" EXACT [] +xref: RESID:AA0324 +is_a: GO:0017003 ! protein-heme linkage +relationship: part_of GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0045329 +name: carnitine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] +synonym: "carnitine anabolism" EXACT [] +synonym: "carnitine biosynthesis" EXACT [] +synonym: "carnitine formation" EXACT [] +synonym: "carnitine synthesis" EXACT [] +synonym: "vitamin Bt biosynthesis" EXACT [] +synonym: "vitamin Bt biosynthetic process" EXACT [] +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0009437 ! carnitine metabolic process + +[Term] +id: GO:0045330 +name: aspartyl esterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB-KW:KW-0063] +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0045331 +name: obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2] +comment: This term was made obsolete because it represents two activities. +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" EXACT [] +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulphide hydrogenase activity" EXACT [] +synonym: "heterodisulfide reductase activity" EXACT [] +is_obsolete: true +consider: GO:0051911 +consider: GO:0051912 + +[Term] +id: GO:0045332 +name: phospholipid translocation +namespace: biological_process +def: "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864] +comment: Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'. +synonym: "flippase" RELATED [] +synonym: "phospholipid scrambling" RELATED [] +is_a: GO:0015914 ! phospholipid transport +is_a: GO:0034204 ! lipid translocation + +[Term] +id: GO:0045333 +name: cellular respiration +namespace: biological_process +def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_pir +subset: goslim_yeast +synonym: "oxidative metabolic process" EXACT [] +synonym: "oxidative metabolism" EXACT [] +synonym: "respiration" BROAD [] +xref: Wikipedia:Cellular_respiration +is_a: GO:0015980 ! energy derivation by oxidation of organic compounds + +[Term] +id: GO:0045334 +name: clathrin-coated endocytic vesicle +namespace: cellular_component +def: "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators] +xref: NIF_Subcellular:sao1243595998 +is_a: GO:0030136 ! clathrin-coated vesicle +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0045335 +name: phagocytic vesicle +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732] +synonym: "phagosome" EXACT [] +xref: Wikipedia:Phagosome +is_a: GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0045336 +name: clathrin-coated phagocytic vesicle +namespace: cellular_component +def: "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732] +synonym: "clathrin-coated phagosome" EXACT [] +is_a: GO:0045334 ! clathrin-coated endocytic vesicle +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0045337 +name: farnesyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of farnesyl diphosphate." [GOC:jl] +synonym: "farnesyl diphosphate anabolism" EXACT [] +synonym: "farnesyl diphosphate biosynthesis" EXACT [] +synonym: "farnesyl diphosphate formation" EXACT [] +synonym: "farnesyl diphosphate synthesis" EXACT [] +xref: MetaCyc:PWY-5123 +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016114 ! terpenoid biosynthetic process +is_a: GO:0045338 ! farnesyl diphosphate metabolic process + +[Term] +id: GO:0045338 +name: farnesyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators] +synonym: "farnesyl diphosphate metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0045339 +name: farnesyl diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators] +synonym: "farnesyl diphosphate breakdown" EXACT [] +synonym: "farnesyl diphosphate catabolism" EXACT [] +synonym: "farnesyl diphosphate degradation" EXACT [] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0016115 ! terpenoid catabolic process +is_a: GO:0045338 ! farnesyl diphosphate metabolic process + +[Term] +id: GO:0045340 +name: mercury ion binding +namespace: molecular_function +def: "Binding to a mercury ion (Hg)." [GOC:go_curators] +synonym: "Hg ion binding" EXACT [] +synonym: "mercury binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0045341 +name: MHC class I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators] +synonym: "major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "MHC class I anabolism" EXACT [] +synonym: "MHC class I biosynthesis" EXACT [] +synonym: "MHC class I formation" EXACT [] +synonym: "MHC class I synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0045342 +name: MHC class II biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators] +synonym: "major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "MHC class II anabolism" EXACT [] +synonym: "MHC class II biosynthesis" EXACT [] +synonym: "MHC class II formation" EXACT [] +synonym: "MHC class II synthesis" EXACT [] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0045343 +name: regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "regulation of MHC class I anabolism" EXACT [] +synonym: "regulation of MHC class I biosynthesis" EXACT [] +synonym: "regulation of MHC class I formation" EXACT [] +synonym: "regulation of MHC class I synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045344 +name: negative regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "down regulation of MHC class I biosynthetic process" EXACT [] +synonym: "down-regulation of MHC class I biosynthetic process" EXACT [] +synonym: "downregulation of MHC class I biosynthetic process" EXACT [] +synonym: "inhibition of MHC class I biosynthetic process" NARROW [] +synonym: "negative regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "negative regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "negative regulation of MHC class I anabolism" EXACT [] +synonym: "negative regulation of MHC class I biosynthesis" EXACT [] +synonym: "negative regulation of MHC class I formation" EXACT [] +synonym: "negative regulation of MHC class I synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045343 ! regulation of MHC class I biosynthetic process +relationship: negatively_regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045345 +name: positive regulation of MHC class I biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators] +synonym: "activation of MHC class I biosynthetic process" NARROW [] +synonym: "positive regulation of major histocompatibility complex class I biosynthesis" EXACT [] +synonym: "positive regulation of major histocompatibility complex class I biosynthetic process" EXACT [] +synonym: "positive regulation of MHC class I anabolism" EXACT [] +synonym: "positive regulation of MHC class I biosynthesis" EXACT [] +synonym: "positive regulation of MHC class I formation" EXACT [] +synonym: "positive regulation of MHC class I synthesis" EXACT [] +synonym: "stimulation of MHC class I biosynthetic process" NARROW [] +synonym: "up regulation of MHC class I biosynthetic process" EXACT [] +synonym: "up-regulation of MHC class I biosynthetic process" EXACT [] +synonym: "upregulation of MHC class I biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045343 ! regulation of MHC class I biosynthetic process +relationship: positively_regulates GO:0045341 ! MHC class I biosynthetic process + +[Term] +id: GO:0045346 +name: regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "regulation of MHC class II anabolism" EXACT [] +synonym: "regulation of MHC class II biosynthesis" EXACT [] +synonym: "regulation of MHC class II formation" EXACT [] +synonym: "regulation of MHC class II synthesis" EXACT [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045347 +name: negative regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "down regulation of MHC class II biosynthetic process" EXACT [] +synonym: "down-regulation of MHC class II biosynthetic process" EXACT [] +synonym: "downregulation of MHC class II biosynthetic process" EXACT [] +synonym: "inhibition of MHC class II biosynthetic process" NARROW [] +synonym: "negative regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "negative regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "negative regulation of MHC class II anabolism" EXACT [] +synonym: "negative regulation of MHC class II biosynthesis" EXACT [] +synonym: "negative regulation of MHC class II formation" EXACT [] +synonym: "negative regulation of MHC class II synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045346 ! regulation of MHC class II biosynthetic process +relationship: negatively_regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045348 +name: positive regulation of MHC class II biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators] +synonym: "activation of MHC class II biosynthetic process" NARROW [] +synonym: "positive regulation of major histocompatibility complex class II biosynthesis" EXACT [] +synonym: "positive regulation of major histocompatibility complex class II biosynthetic process" EXACT [] +synonym: "positive regulation of MHC class II anabolism" EXACT [] +synonym: "positive regulation of MHC class II biosynthesis" EXACT [] +synonym: "positive regulation of MHC class II formation" EXACT [] +synonym: "positive regulation of MHC class II synthesis" EXACT [] +synonym: "stimulation of MHC class II biosynthetic process" NARROW [] +synonym: "up regulation of MHC class II biosynthetic process" EXACT [] +synonym: "up-regulation of MHC class II biosynthetic process" EXACT [] +synonym: "upregulation of MHC class II biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045346 ! regulation of MHC class II biosynthetic process +relationship: positively_regulates GO:0045342 ! MHC class II biosynthetic process + +[Term] +id: GO:0045352 +name: interleukin-1 type I receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to interleukin-1 type I receptors." [GOC:ebc] +synonym: "IL-1ra type I" EXACT [] +is_a: GO:0005152 ! interleukin-1 receptor antagonist activity + +[Term] +id: GO:0045353 +name: interleukin-1 type II receptor antagonist activity +namespace: molecular_function +def: "Blocks the binding of interleukin-1 to interleukin-1 type II receptors." [GOC:ebc] +synonym: "IL-1ra type II" EXACT [] +is_a: GO:0005152 ! interleukin-1 receptor antagonist activity + +[Term] +id: GO:0045427 +name: obsolete enzyme active site formation via (phospho-5'-guanosine)-L-histidine +namespace: biological_process +def: "OBSOLETE. The transient guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:10529169. +is_obsolete: true +consider: GO:0036428 + +[Term] +id: GO:0045428 +name: regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "regulation of nitric oxide anabolism" EXACT [] +synonym: "regulation of nitric oxide biosynthesis" EXACT [] +synonym: "regulation of nitric oxide formation" EXACT [] +synonym: "regulation of nitric oxide synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0080164 ! regulation of nitric oxide metabolic process +relationship: regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045429 +name: positive regulation of nitric oxide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators] +synonym: "activation of nitric oxide biosynthetic process" NARROW [] +synonym: "positive regulation of nitric oxide anabolism" EXACT [] +synonym: "positive regulation of nitric oxide biosynthesis" EXACT [] +synonym: "positive regulation of nitric oxide formation" EXACT [] +synonym: "positive regulation of nitric oxide synthesis" EXACT [] +synonym: "stimulation of nitric oxide biosynthetic process" NARROW [] +synonym: "up regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "up-regulation of nitric oxide biosynthetic process" EXACT [] +synonym: "upregulation of nitric oxide biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045428 ! regulation of nitric oxide biosynthetic process +is_a: GO:1904407 ! positive regulation of nitric oxide metabolic process +relationship: positively_regulates GO:0006809 ! nitric oxide biosynthetic process + +[Term] +id: GO:0045430 +name: chalcone isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: a chalcone = a flavanone." [EC:5.5.1.6] +synonym: "chalcone--flavonone isomerase activity" RELATED [EC:5.5.1.6] +synonym: "chalcone-flavanone isomerase activity" EXACT [] +synonym: "flavanone lyase (decyclizing)" RELATED [EC:5.5.1.6] +xref: EC:5.5.1.6 +xref: MetaCyc:CHALCONE-ISOMERASE-RXN +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0045431 +name: flavonol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." [EC:1.14.20.6, ISBN:0943088372, PMID:7904213] +synonym: "dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.20.6] +synonym: "flavonoid 2-oxoglutarate-dependent dioxygenase activity" RELATED [EC:1.14.20.6] +synonym: "FLS activity" RELATED [EC:1.14.20.6] +xref: EC:1.14.20.6 +xref: RHEA:21088 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0045433 +name: male courtship behavior, veined wing generated song production +namespace: biological_process +def: "The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song." [GOC:mtg_sensu, PMID:11092827] +synonym: "male courtship behavior, song production" BROAD [] +synonym: "male courtship behaviour, song production" BROAD [] +synonym: "male courtship behaviour, veined wing generated song production" EXACT [] +is_a: GO:0008049 ! male courtship behavior +relationship: part_of GO:0016545 ! male courtship behavior, veined wing vibration + +[Term] +id: GO:0045434 +name: negative regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating." [GOC:bf, PMID:11092827] +synonym: "down regulation of female receptivity, post-mating" EXACT [] +synonym: "down-regulation of female receptivity, post-mating" EXACT [] +synonym: "downregulation of female receptivity, post-mating" EXACT [] +synonym: "inhibition of female receptivity, post-mating" NARROW [] +is_a: GO:0007621 ! negative regulation of female receptivity +is_a: GO:0046008 ! regulation of female receptivity, post-mating + +[Term] +id: GO:0045435 +name: lycopene epsilon cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene)." [PMID:8837512] +synonym: "lycopene cyclase" BROAD [] +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0045436 +name: lycopene beta cyclase activity +namespace: molecular_function +def: "Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively." [PMID:8837512] +synonym: "crtL" RELATED [] +synonym: "lycopene cyclase" BROAD [] +xref: MetaCyc:RXN1F-150 +xref: RHEA:32219 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0045437 +name: uridine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil." [EC:3.2.2.3, RHEA:15577] +synonym: "uridine hydrolase activity" EXACT [] +synonym: "uridine ribohydrolase activity" RELATED [EC:3.2.2.3] +xref: EC:3.2.2.3 +xref: KEGG_REACTION:R01080 +xref: MetaCyc:URIDINE-NUCLEOSIDASE-RXN +xref: RHEA:15577 +is_a: GO:0050263 ! ribosylpyrimidine nucleosidase activity + +[Term] +id: GO:0045438 +name: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity +namespace: molecular_function +def: "Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol." [PMID:1572368, PMID:2061333] +synonym: "ACV synthetase activity" BROAD [] +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0045439 +name: isopenicillin-N epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopenicillin N = penicillin N." [EC:5.1.1.17, RHEA:20033] +synonym: "isopenicillin N epimerase activity" EXACT [] +synonym: "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity" RELATED [EC:5.1.1.17] +xref: EC:5.1.1.17 +xref: KEGG_REACTION:R04147 +xref: MetaCyc:5.1.1.17-RXN +xref: RHEA:20033 +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0045442 +name: deacetoxycephalosporin-C hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate." [EC:1.14.11.26, RHEA:16805] +synonym: "3'-methylcephem hydroxylase activity" RELATED [EC:1.14.11.26] +synonym: "beta-lactam hydroxylase activity" EXACT [] +synonym: "DACS" RELATED [EC:1.14.11.26] +synonym: "DAOC hydroxylase activity" RELATED [EC:1.14.11.26] +synonym: "deacetoxycephalosporin C hydroxylase activity" RELATED [EC:1.14.11.26] +synonym: "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.26] +synonym: "deacetylcephalosporin C synthase activity" RELATED [EC:1.14.11.26] +xref: EC:1.14.11.26 +xref: KEGG_REACTION:R05229 +xref: MetaCyc:1.14.11.26-RXN +xref: RHEA:16805 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0045443 +name: juvenile hormone secretion +namespace: biological_process +def: "The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] +is_a: GO:0046865 ! terpenoid transport +is_a: GO:0060986 ! endocrine hormone secretion +is_a: GO:0140353 ! lipid export from cell + +[Term] +id: GO:0045444 +name: fat cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat." [CL:0000136, GOC:go_curators] +synonym: "adipocyte cell differentiation" EXACT [] +synonym: "adipocyte differentiation" EXACT [] +synonym: "adipogenesis" RELATED [] +synonym: "adipose cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0045445 +name: myoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +synonym: "myoblast cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0061061 ! muscle structure development + +[Term] +id: GO:0045446 +name: endothelial cell differentiation +namespace: biological_process +def: "The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [CL:0000115, GOC:go_curators] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0003158 ! endothelium development + +[Term] +id: GO:0045448 +name: mitotic cell cycle, embryonic +namespace: biological_process +def: "The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." [GOC:go_curators] +is_a: GO:0000278 ! mitotic cell cycle +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0045450 +name: bicoid mRNA localization +namespace: biological_process +def: "Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis." [GOC:go_curators] +synonym: "bicoid mRNA localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of bicoid mRNA localization" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification +relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification + +[Term] +id: GO:0045451 +name: pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "establishment and maintenance of oskar mRNA localization in pole plasm" EXACT [] +synonym: "establishment and maintenance of pole plasm oskar mRNA localization" EXACT [] +synonym: "oocyte pole plasm oskar mRNA localization" EXACT [] +synonym: "pole plasm oskar mRNA localisation" EXACT [GOC:mah] +is_a: GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0045453 +name: bone resorption +namespace: biological_process +def: "The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products." [GOC:mah, PMID:10968780] +xref: Wikipedia:Bone_resorption +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0046849 ! bone remodeling + +[Term] +id: GO:0045454 +name: cell redox homeostasis +namespace: biological_process +alt_id: GO:0030503 +alt_id: GO:0045867 +alt_id: GO:0045868 +def: "Any process that maintains the redox environment of a cell or compartment within a cell." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_drosophila +subset: goslim_metagenomics +synonym: "regulation of cell redox homeostasis" RELATED [] +synonym: "regulation of redox homeostasis" BROAD [] +xref: Wikipedia:Redox +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0045455 +name: ecdysteroid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] +synonym: "ecdysteroid metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0034754 ! cellular hormone metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +relationship: part_of GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0045456 +name: ecdysteroid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] +synonym: "ecdysteroid anabolism" EXACT [] +synonym: "ecdysteroid biosynthesis" EXACT [] +synonym: "ecdysteroid formation" EXACT [] +synonym: "ecdysteroid synthesis" EXACT [] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0045455 ! ecdysteroid metabolic process +is_a: GO:0120178 ! steroid hormone biosynthetic process + +[Term] +id: GO:0045457 +name: ecdysteroid secretion +namespace: biological_process +def: "The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:go_curators] +is_a: GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:0045458 +name: recombination within rDNA repeats +namespace: biological_process +def: "Genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] +comment: Note that this term was reinstated from obsolete. +synonym: "recombination within ribosomal DNA repeats" EXACT [] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0043007 ! maintenance of rDNA + +[Term] +id: GO:0045459 +name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide." [PMID:11592901, RESID:AA0326] +synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide" EXACT [] +xref: RESID:AA0326 +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0045460 +name: sterigmatocystin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248] +synonym: "sterigmatocystin metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:0045461 +name: sterigmatocystin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [PMID:10618248] +synonym: "sterigmatocystin anabolism" EXACT [] +synonym: "sterigmatocystin biosynthesis" EXACT [] +synonym: "sterigmatocystin formation" EXACT [] +synonym: "sterigmatocystin synthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0045460 ! sterigmatocystin metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:0045462 +name: trichothecene 3-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis." [PMID:10583973] +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0045463 +name: R8 cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium." [PMID:11880339] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045464 +name: R8 cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [PMID:11880339] +is_a: GO:0043704 ! photoreceptor cell fate specification +relationship: part_of GO:0007460 ! R8 cell fate commitment + +[Term] +id: GO:0045465 +name: R8 cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor." [PMID:11880339] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0045466 +name: R7 cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor." [PMID:11880339] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0045467 +name: R7 cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium." [PMID:11880339] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045468 +name: regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc." [GOC:dph, GOC:tb, PMID:11880339] +synonym: "R8 cell spacing in compound eye" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of R8 spacing" EXACT [GOC:dph] +is_a: GO:0007389 ! pattern specification process +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0045469 +name: negative regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye." [GOC:dph, GOC:tb, PMID:11880339] +synonym: "down regulation of R8 spacing" EXACT [] +synonym: "down-regulation of R8 spacing" EXACT [] +synonym: "downregulation of R8 spacing" EXACT [] +synonym: "inhibition of R8 spacing" NARROW [] +is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye + +[Term] +id: GO:0045470 +name: R8 cell-mediated photoreceptor organization +namespace: biological_process +def: "The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor." [PMID:11880339] +synonym: "R8-mediated photoreceptor organisation" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0042051 ! compound eye photoreceptor development + +[Term] +id: GO:0045471 +name: response to ethanol +namespace: biological_process +alt_id: GO:0017036 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators] +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0045472 +name: response to ether +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0045473 +name: obsolete response to ethanol (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:go_curators, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "response to ethanol (sensu Insecta)" EXACT [] +is_obsolete: true +consider: GO:0048149 + +[Term] +id: GO:0045474 +name: obsolete response to ether (sensu Insecta) +namespace: biological_process +def: "OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus." [GOC:go_curators, GOC:jid] +comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. +synonym: "response to ether (sensu Insecta)" EXACT [] +is_obsolete: true +consider: GO:0048150 + +[Term] +id: GO:0045475 +name: locomotor rhythm +namespace: biological_process +def: "The rhythm of the locomotor activity of an organism during its 24 hour activity cycle." [GOC:go_curators] +synonym: "circadian locomotor activity rhythm" NARROW [] +is_a: GO:0007626 ! locomotory behavior +is_a: GO:0048512 ! circadian behavior + +[Term] +id: GO:0045476 +name: nurse cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process." [CL:0000026, GOC:mtg_apoptosis, PMID:11973306] +synonym: "apoptosis of nurse cells" EXACT [] +synonym: "invertebrate nurse cell apoptosis" NARROW [] +synonym: "nurse cell apoptosis" NARROW [] +synonym: "nurse cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of nurse cells by apoptosis" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010623 ! programmed cell death involved in cell development +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0045477 +name: regulation of nurse cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nurse cell apoptotic process." [GOC:mtg_apoptosis, PMID:11973306] +synonym: "regulation of nurse cell apoptosis" NARROW [] +is_a: GO:1904748 ! regulation of apoptotic process involved in development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0045476 ! nurse cell apoptotic process + +[Term] +id: GO:0045478 +name: fusome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells." [GOC:dph, GOC:go_curators, GOC:jl, GOC:mah] +subset: goslim_pir +synonym: "fusome organisation" EXACT [] +synonym: "fusome organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism + +[Term] +id: GO:0045479 +name: vesicle targeting to fusome +namespace: biological_process +def: "The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome." [PMID:9046244] +synonym: "vesicle-fusome targeting" EXACT [] +is_a: GO:0006903 ! vesicle targeting +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0045478 ! fusome organization + +[Term] +id: GO:0045480 +name: galactose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide." [EC:1.1.3.9] +synonym: "beta-galactose oxidase activity" RELATED [EC:1.1.3.9] +synonym: "D-galactose oxidase activity" RELATED [EC:1.1.3.9] +synonym: "D-galactose:oxygen 6-oxidoreductase activity" RELATED [EC:1.1.3.9] +xref: EC:1.1.3.9 +xref: MetaCyc:GALACTOSE-OXIDASE-RXN +xref: RHEA:24160 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0045481 +name: 6-endo-hydroxycineole dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH." [EC:1.1.1.241, RHEA:11736] +synonym: "6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.241] +xref: EC:1.1.1.241 +xref: KEGG_REACTION:R02994 +xref: MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN +xref: RHEA:11736 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045482 +name: trichodiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene." [EC:4.2.3.6, RHEA:12052] +synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.6] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)" RELATED [EC:4.2.3.6] +synonym: "trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity" RELATED [EC:4.2.3.6] +synonym: "trichodiene synthetase activity" RELATED [EC:4.2.3.6] +xref: EC:4.2.3.6 +xref: KEGG_REACTION:R02306 +xref: MetaCyc:TRICHODIENE-SYNTHASE-RXN +xref: RHEA:12052 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0045483 +name: aristolochene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate." [EC:4.2.3.9] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" RELATED [EC:4.2.3.9] +synonym: "sesquiterpene cyclase activity" BROAD [EC:4.2.3.9] +synonym: "trans,trans-farnesyl diphosphate aristolochene-lyase activity" RELATED [EC:4.2.3.9] +synonym: "trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)" RELATED [EC:4.2.3.9] +xref: EC:4.2.3.9 +xref: MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN +xref: RHEA:19825 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0045484 +name: L-lysine 6-transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine." [EC:2.6.1.36, RHEA:21200] +synonym: "L-lysine aminotransferase activity" RELATED [EC:2.6.1.36] +synonym: "L-lysine transaminase activity" RELATED [EC:2.6.1.36] +synonym: "L-lysine-alpha-ketoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36] +synonym: "L-lysine-alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.36] +synonym: "L-lysine:2-oxoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36] +synonym: "lysine 6-aminotransferase activity" EXACT [] +synonym: "lysine epsilon-aminotransferase activity" RELATED [EC:2.6.1.36] +synonym: "lysine epsilon-transaminase activity" RELATED [EC:2.6.1.36] +synonym: "lysine:2-ketoglutarate 6-aminotransferase activity" RELATED [EC:2.6.1.36] +xref: EC:2.6.1.36 +xref: KEGG_REACTION:R00457 +xref: MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN +xref: RHEA:21200 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0045485 +name: omega-6 fatty acid desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain." [PMID:7846158] +xref: Reactome:R-HSA-2046089 "Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA" +xref: Reactome:R-HSA-2046092 "Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA" +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0045486 +name: naringenin 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2." [EC:1.14.11.9] +synonym: "(2S)-flavanone 3-hydroxylase activity" RELATED [EC:1.14.11.9] +synonym: "flavanone 3-beta-hydroxylase activity" RELATED [EC:1.14.11.9] +synonym: "flavanone 3-dioxygenase activity" RELATED [EC:1.14.11.9] +synonym: "flavanone 3-hydroxylase activity" RELATED [EC:1.14.11.9] +synonym: "flavanone 3beta-hydroxylase activity" RELATED [EC:1.14.11.9] +synonym: "flavanone synthase I activity" RELATED [EC:1.14.11.9] +synonym: "flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.9] +synonym: "naringenin 3-hydroxylase activity" RELATED [EC:1.14.11.9] +synonym: "naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.9] +xref: EC:1.14.11.9 +xref: MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN +xref: RHEA:18621 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0045487 +name: gibberellin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [GOC:go_curators] +synonym: "gibberellic acid breakdown" NARROW [] +synonym: "gibberellic acid catabolic process" NARROW [] +synonym: "gibberellic acid catabolism" NARROW [] +synonym: "gibberellic acid degradation" NARROW [] +synonym: "gibberellin catabolism" EXACT [] +is_a: GO:0009685 ! gibberellin metabolic process +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0016103 ! diterpenoid catabolic process + +[Term] +id: GO:0045488 +name: pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge." [GOC:tair_curators] +synonym: "pectin metabolism" EXACT [] +is_a: GO:0010393 ! galacturonan metabolic process + +[Term] +id: GO:0045489 +name: pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] +synonym: "pectin anabolism" EXACT [] +synonym: "pectin biosynthesis" EXACT [] +synonym: "pectin formation" EXACT [] +synonym: "pectin synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0045488 ! pectin metabolic process + +[Term] +id: GO:0045490 +name: pectin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." [GOC:go_curators, PMID:11931668] +synonym: "pectin breakdown" EXACT [] +synonym: "pectin catabolism" EXACT [] +synonym: "pectin degradation" EXACT [] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0045488 ! pectin metabolic process + +[Term] +id: GO:0045491 +name: xylan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +synonym: "xylan metabolism" EXACT [] +is_a: GO:0010410 ! hemicellulose metabolic process + +[Term] +id: GO:0045492 +name: xylan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +synonym: "xylan anabolism" EXACT [] +synonym: "xylan biosynthesis" EXACT [] +synonym: "xylan formation" EXACT [] +synonym: "xylan synthesis" EXACT [] +is_a: GO:0045491 ! xylan metabolic process +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0045493 +name: xylan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone." [GOC:go_curators, PMID:11931668] +synonym: "xylan breakdown" EXACT [] +synonym: "xylan catabolism" EXACT [] +synonym: "xylan degradation" EXACT [] +is_a: GO:0044347 ! cell wall polysaccharide catabolic process +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:0045494 +name: photoreceptor cell maintenance +namespace: biological_process +def: "Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light." [CL:0000210, GOC:bf, GOC:rl] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0001895 ! retina homeostasis + +[Term] +id: GO:0045495 +name: pole plasm +namespace: cellular_component +def: "Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo." [GOC:kmv, PMID:17113380] +synonym: "germ plasm" NARROW [] +synonym: "polar plasm" EXACT [] +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:0045496 +name: male analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] +is_a: GO:0007487 ! analia development + +[Term] +id: GO:0045497 +name: female analia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] +is_a: GO:0007487 ! analia development + +[Term] +id: GO:0045498 +name: sex comb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg." [http://fly.ebi.ac.uk] +is_a: GO:0007423 ! sensory organ development + +[Term] +id: GO:0045499 +name: chemorepellent activity +namespace: molecular_function +def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal." [GOC:ai] +subset: goslim_pir +synonym: "chemorepellant activity" EXACT [] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0045500 +name: sevenless signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:10771085] +synonym: "sev receptor signaling pathway" EXACT [] +synonym: "sev signaling pathway" EXACT [] +synonym: "sevenless signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0007465 ! R7 cell fate commitment + +[Term] +id: GO:0045501 +name: regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "regulation of sev signaling pathway" EXACT [] +synonym: "regulation of sevenless signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0045676 ! regulation of R7 cell differentiation +relationship: regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045503 +name: dynein light chain binding +namespace: molecular_function +def: "Binding to a light chain of the dynein complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045504 +name: dynein heavy chain binding +namespace: molecular_function +def: "Binding to a heavy chain of the dynein complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045505 +name: dynein intermediate chain binding +namespace: molecular_function +def: "Binding to an intermediate chain of the dynein complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045506 +name: interleukin-24 receptor activity +namespace: molecular_function +def: "Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-24 receptor activity" EXACT [GOC:mah] +synonym: "IL-24R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0045507 +name: interleukin-25 receptor activity +namespace: molecular_function +def: "Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-25 receptor activity" EXACT [GOC:mah] +synonym: "IL-25R" EXACT [] +is_a: GO:0030368 ! interleukin-17 receptor activity + +[Term] +id: GO:0045508 +name: interleukin-26 receptor activity +namespace: molecular_function +def: "Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-26 receptor activity" EXACT [GOC:mah] +synonym: "IL-26R" EXACT [] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0045509 +name: interleukin-27 receptor activity +namespace: molecular_function +def: "Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] +synonym: "IL-27 receptor activity" EXACT [GOC:mah] +synonym: "IL-27R" EXACT [] +is_a: GO:0030368 ! interleukin-17 receptor activity + +[Term] +id: GO:0045510 +name: interleukin-24 binding +namespace: molecular_function +def: "Binding to interleukin-24." [GOC:go_curators] +synonym: "IL-24 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045511 +name: interleukin-25 binding +namespace: molecular_function +def: "Binding to interleukin-25." [GOC:go_curators] +synonym: "IL-25 binding" EXACT [] +is_a: GO:0019975 ! interleukin-17 binding + +[Term] +id: GO:0045512 +name: interleukin-26 binding +namespace: molecular_function +def: "Binding to interleukin-26." [GOC:go_curators] +synonym: "IL-26 binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0045513 +name: interleukin-27 binding +namespace: molecular_function +def: "Binding to interleukin-27." [GOC:go_curators] +synonym: "IL-27 binding" EXACT [] +is_a: GO:0019975 ! interleukin-17 binding + +[Term] +id: GO:0045514 +name: interleukin-16 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-16 receptor." [GOC:go_curators] +synonym: "IL-16" NARROW [] +synonym: "interleukin-16 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045515 +name: interleukin-18 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-18 receptor." [GOC:go_curators] +synonym: "IL-18" NARROW [] +synonym: "interleukin-18 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045516 +name: interleukin-19 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-19 receptor." [GOC:go_curators] +synonym: "IL-19" NARROW [] +synonym: "interleukin-19 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045517 +name: interleukin-20 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-20 receptor." [GOC:go_curators] +synonym: "IL-20" NARROW [] +synonym: "interleukin-20 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045518 +name: interleukin-22 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-22 receptor." [GOC:go_curators] +synonym: "IL-22" NARROW [] +synonym: "interleukin-22 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045519 +name: interleukin-23 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-23 receptor." [GOC:go_curators] +synonym: "IL-23" NARROW [] +synonym: "interleukin-23 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045520 +name: interleukin-24 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-24 receptor." [GOC:go_curators] +synonym: "IL-24" NARROW [] +synonym: "interleukin-24 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045521 +name: interleukin-25 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-25 receptor." [GOC:go_curators] +synonym: "IL-25" NARROW [] +synonym: "interleukin-25 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045522 +name: interleukin-26 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-26 receptor." [GOC:go_curators] +synonym: "IL-26" NARROW [] +synonym: "interleukin-26 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045523 +name: interleukin-27 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-27 receptor." [GOC:go_curators] +synonym: "IL-27" NARROW [] +synonym: "interleukin-27 receptor ligand" NARROW [] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0045540 +name: regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "regulation of cholesterol anabolism" EXACT [] +synonym: "regulation of cholesterol biosynthesis" EXACT [] +synonym: "regulation of cholesterol formation" EXACT [] +synonym: "regulation of cholesterol synthesis" EXACT [] +is_a: GO:0090181 ! regulation of cholesterol metabolic process +is_a: GO:0106118 ! regulation of sterol biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045541 +name: negative regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "down regulation of cholesterol biosynthetic process" EXACT [] +synonym: "down-regulation of cholesterol biosynthetic process" EXACT [] +synonym: "downregulation of cholesterol biosynthetic process" EXACT [] +synonym: "inhibition of cholesterol biosynthetic process" NARROW [] +synonym: "negative regulation of cholesterol anabolism" EXACT [] +synonym: "negative regulation of cholesterol biosynthesis" EXACT [] +synonym: "negative regulation of cholesterol formation" EXACT [] +synonym: "negative regulation of cholesterol synthesis" EXACT [] +is_a: GO:0045540 ! regulation of cholesterol biosynthetic process +is_a: GO:0090206 ! negative regulation of cholesterol metabolic process +is_a: GO:0106119 ! negative regulation of sterol biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045542 +name: positive regulation of cholesterol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol." [GOC:go_curators] +synonym: "activation of cholesterol biosynthetic process" NARROW [] +synonym: "positive regulation of cholesterol anabolism" EXACT [] +synonym: "positive regulation of cholesterol biosynthesis" EXACT [] +synonym: "positive regulation of cholesterol formation" EXACT [] +synonym: "positive regulation of cholesterol synthesis" EXACT [] +synonym: "stimulation of cholesterol biosynthetic process" NARROW [] +synonym: "up regulation of cholesterol biosynthetic process" EXACT [] +synonym: "up-regulation of cholesterol biosynthetic process" EXACT [] +synonym: "upregulation of cholesterol biosynthetic process" EXACT [] +is_a: GO:0045540 ! regulation of cholesterol biosynthetic process +is_a: GO:0090205 ! positive regulation of cholesterol metabolic process +is_a: GO:0106120 ! positive regulation of sterol biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0006695 ! cholesterol biosynthetic process + +[Term] +id: GO:0045543 +name: gibberellin 2-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2." [EC:1.14.11.13, GOC:kad] +synonym: "(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" NARROW [EC:1.14.11.13] +synonym: "gibberellin 2-beta-hydroxylase activity" RELATED [EC:1.14.11.13] +synonym: "gibberellin 2-oxidase activity" EXACT [] +synonym: "gibberellin 2beta-dioxygenase activity" RELATED [EC:1.14.11.13] +synonym: "gibberellin 2beta-hydroxylase activity" RELATED [EC:1.14.11.13] +xref: EC:1.14.11.13 +xref: MetaCyc:PWY-102 +xref: RHEA:15005 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0045544 +name: gibberellin 20-oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones." [PMID:7604047] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0045545 +name: syndecan binding +namespace: molecular_function +def: "Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells." [GOC:go_curators, PMID:9355727] +is_a: GO:0043394 ! proteoglycan binding + +[Term] +id: GO:0045547 +name: dehydrodolichyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0045548 +name: phenylalanine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate." [RHEA:21384] +synonym: "L-phenylalanine ammonia-lyase activity" RELATED [EC:4.3.1.24] +synonym: "PAL activity" BROAD [EC:4.3.1.24] +synonym: "phe ammonia-lyase activity" RELATED [EC:4.3.1.24] +synonym: "phenylalanine ammonium-lyase activity" RELATED [EC:4.3.1.24] +synonym: "phenylalanine deaminase activity" RELATED [EC:4.3.1.24] +xref: EC:4.3.1.24 +xref: EC:4.3.1.25 +xref: RHEA:21384 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0045549 +name: 9-cis-epoxycarotenoid dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al." [EC:1.13.11.51] +synonym: "9-cis-epoxycarotenoid 11,12-dioxygenase activity" RELATED [EC:1.13.11.51] +synonym: "AtNCED3" RELATED [EC:1.13.11.51] +synonym: "NCED" RELATED [EC:1.13.11.51] +synonym: "neoxanthin cleavage enzyme" RELATED [] +synonym: "nine-cis-epoxycarotenoid dioxygenase activity" RELATED [EC:1.13.11.51] +synonym: "PvNCED1" RELATED [EC:1.13.11.51] +synonym: "VP14" RELATED [EC:1.13.11.51] +xref: EC:1.13.11.51 +is_a: GO:0010436 ! carotenoid dioxygenase activity + +[Term] +id: GO:0045550 +name: geranylgeranyl reductase activity +namespace: molecular_function +def: "Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group." [PMID:9492312] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0045551 +name: cinnamyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+." [EC:1.1.1.195] +synonym: "CAD activity" BROAD [EC:1.1.1.195] +synonym: "cinnamyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.195] +synonym: "cinnamyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.195] +xref: EC:1.1.1.195 +xref: MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:10392 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045552 +name: dihydrokaempferol 4-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+." [EC:1.1.1.219] +synonym: "cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.219] +synonym: "dihydroflavanol 4-reductase activity" RELATED [EC:1.1.1.219] +synonym: "dihydroflavonol 4-reductase activity" RELATED [EC:1.1.1.219] +synonym: "dihydromyricetin reductase activity" RELATED [EC:1.1.1.219] +synonym: "dihydroquercetin reductase activity" RELATED [EC:1.1.1.219] +synonym: "NADPH-dihydromyricetin reductase activity" RELATED [EC:1.1.1.219] +xref: EC:1.1.1.219 +xref: MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN +xref: RHEA:23016 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0045557 +name: obsolete TRAIL receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "TRAIL receptor anabolism" EXACT [] +synonym: "TRAIL receptor biosynthesis" EXACT [] +synonym: "TRAIL receptor formation" EXACT [] +synonym: "TRAIL receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045558 +name: obsolete TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R1 (TNF-related apoptosis inducing ligand receptor 1), which engages a caspase-dependent apoptotic pathway." [GOC:go_curators, PMID:9311998] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "TRAIL receptor 1 anabolism" EXACT [] +synonym: "TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "TRAIL receptor 1 formation" EXACT [] +synonym: "TRAIL receptor 1 synthesis" EXACT [] +synonym: "tumor necrosis factor receptor superfamily member 10A biosynthetic process" EXACT [PR:000002108] +is_obsolete: true + +[Term] +id: GO:0045559 +name: obsolete TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1." [GOC:go_curators, PMID:9311998] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "TRAIL receptor 2 anabolism" EXACT [] +synonym: "TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "TRAIL receptor 2 formation" EXACT [] +synonym: "TRAIL receptor 2 synthesis" EXACT [] +synonym: "tumor necrosis factor receptor superfamily member 10B biosynthetic process" EXACT [PR:000002109] +is_obsolete: true + +[Term] +id: GO:0045560 +name: obsolete regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "regulation of TRAIL receptor anabolism" EXACT [] +synonym: "regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor formation" EXACT [] +synonym: "regulation of TRAIL receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045561 +name: obsolete regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "regulation of TRAIL receptor 1 synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045562 +name: obsolete regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "regulation of TRAIL receptor 2 synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045563 +name: obsolete negative regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "down regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor formation" EXACT [] +synonym: "negative regulation of TRAIL receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045564 +name: obsolete positive regulation of TRAIL receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the TRAIL (TNF-related apoptosis inducing ligand) receptor." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "activation of TRAIL receptor biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor formation" EXACT [] +synonym: "positive regulation of TRAIL receptor synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045565 +name: obsolete negative regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "down regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "negative regulation of TRAIL receptor 1 synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045566 +name: obsolete positive regulation of TRAIL receptor 1 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 1." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "activation of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor 1 anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 formation" EXACT [] +synonym: "positive regulation of TRAIL receptor 1 synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor 1 biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor 1 biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor 1 biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045567 +name: obsolete negative regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "down regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "down-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "downregulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "inhibition of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "negative regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "negative regulation of TRAIL receptor 2 synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045568 +name: obsolete positive regulation of TRAIL receptor 2 biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL (TNF-related apoptosis inducing ligand) receptor 2." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "activation of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "positive regulation of TRAIL receptor 2 anabolism" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 biosynthesis" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 formation" EXACT [] +synonym: "positive regulation of TRAIL receptor 2 synthesis" EXACT [] +synonym: "stimulation of TRAIL receptor 2 biosynthetic process" NARROW [] +synonym: "up regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "up-regulation of TRAIL receptor 2 biosynthetic process" EXACT [] +synonym: "upregulation of TRAIL receptor 2 biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045569 +name: TRAIL binding +namespace: molecular_function +def: "Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] +subset: goslim_chembl +synonym: "Apo-2L binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0045570 +name: regulation of imaginal disc growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the growth of the imaginal disc." [GOC:go_curators] +is_a: GO:0046620 ! regulation of organ growth +relationship: regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045571 +name: negative regulation of imaginal disc growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] +synonym: "down regulation of imaginal disc growth" EXACT [] +synonym: "down-regulation of imaginal disc growth" EXACT [] +synonym: "downregulation of imaginal disc growth" EXACT [] +synonym: "inhibition of imaginal disc growth" NARROW [] +is_a: GO:0045570 ! regulation of imaginal disc growth +is_a: GO:0046621 ! negative regulation of organ growth +relationship: negatively_regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045572 +name: positive regulation of imaginal disc growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of imaginal disc growth." [GOC:go_curators] +synonym: "activation of imaginal disc growth" NARROW [] +synonym: "stimulation of imaginal disc growth" NARROW [] +synonym: "up regulation of imaginal disc growth" EXACT [] +synonym: "up-regulation of imaginal disc growth" EXACT [] +synonym: "upregulation of imaginal disc growth" EXACT [] +is_a: GO:0045570 ! regulation of imaginal disc growth +is_a: GO:0046622 ! positive regulation of organ growth +relationship: positively_regulates GO:0007446 ! imaginal disc growth + +[Term] +id: GO:0045574 +name: sterigmatocystin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:go_curators] +synonym: "sterigmatocystin breakdown" EXACT [] +synonym: "sterigmatocystin catabolism" EXACT [] +synonym: "sterigmatocystin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0045460 ! sterigmatocystin metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:0045575 +name: basophil activation +namespace: biological_process +def: "The change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] +xref: Wikipedia:Basophil_activation +is_a: GO:0036230 ! granulocyte activation + +[Term] +id: GO:0045576 +name: mast cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:mgi_curators, ISBN:0781735149] +is_a: GO:0002274 ! myeloid leukocyte activation + +[Term] +id: GO:0045577 +name: regulation of B cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of B cell development" RELATED [GOC:add] +synonym: "regulation of B lymphocyte differentiation" EXACT [] +synonym: "regulation of B-cell differentiation" EXACT [] +synonym: "regulation of B-lymphocyte differentiation" EXACT [] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0050864 ! regulation of B cell activation +relationship: regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045578 +name: negative regulation of B cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of B cell differentiation" EXACT [] +synonym: "down-regulation of B cell differentiation" EXACT [] +synonym: "downregulation of B cell differentiation" EXACT [] +synonym: "inhibition of B cell differentiation" NARROW [] +synonym: "negative regulation of B cell development" RELATED [GOC:add] +synonym: "negative regulation of B lymphocyte differentiation" EXACT [] +synonym: "negative regulation of B-cell differentiation" EXACT [] +synonym: "negative regulation of B-lymphocyte differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +is_a: GO:0050869 ! negative regulation of B cell activation +relationship: negatively_regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045579 +name: positive regulation of B cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of B cell differentiation" NARROW [] +synonym: "positive regulation of B cell development" RELATED [GOC:add] +synonym: "positive regulation of B lymphocyte differentiation" EXACT [] +synonym: "positive regulation of B-cell differentiation" EXACT [] +synonym: "positive regulation of B-lymphocyte differentiation" EXACT [] +synonym: "stimulation of B cell differentiation" NARROW [] +synonym: "up regulation of B cell differentiation" EXACT [] +synonym: "up-regulation of B cell differentiation" EXACT [] +synonym: "upregulation of B cell differentiation" EXACT [] +is_a: GO:0045577 ! regulation of B cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +is_a: GO:0050871 ! positive regulation of B cell activation +relationship: positively_regulates GO:0030183 ! B cell differentiation + +[Term] +id: GO:0045580 +name: regulation of T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of T cell development" RELATED [GOC:add] +synonym: "regulation of T lymphocyte differentiation" EXACT [] +synonym: "regulation of T-cell differentiation" EXACT [] +synonym: "regulation of T-lymphocyte differentiation" EXACT [] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045581 +name: negative regulation of T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of T cell differentiation" EXACT [] +synonym: "down-regulation of T cell differentiation" EXACT [] +synonym: "downregulation of T cell differentiation" EXACT [] +synonym: "inhibition of T cell differentiation" NARROW [] +synonym: "negative regulation of T cell development" RELATED [GOC:add] +synonym: "negative regulation of T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of T-cell differentiation" EXACT [] +synonym: "negative regulation of T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0045620 ! negative regulation of lymphocyte differentiation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045582 +name: positive regulation of T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of T cell differentiation" NARROW [] +synonym: "positive regulation of T cell development" RELATED [GOC:add] +synonym: "positive regulation of T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of T-cell differentiation" EXACT [] +synonym: "positive regulation of T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of T cell differentiation" NARROW [] +synonym: "up regulation of T cell differentiation" EXACT [] +synonym: "up-regulation of T cell differentiation" EXACT [] +synonym: "upregulation of T cell differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0045621 ! positive regulation of lymphocyte differentiation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0030217 ! T cell differentiation + +[Term] +id: GO:0045583 +name: regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of cytotoxic T cell development" RELATED [GOC:add] +synonym: "regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045584 +name: negative regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "down-regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "downregulation of cytotoxic T cell differentiation" EXACT [] +synonym: "inhibition of cytotoxic T cell differentiation" NARROW [] +synonym: "negative regulation of cytotoxic T cell development" RELATED [GOC:add] +synonym: "negative regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "negative regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation +relationship: negatively_regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045585 +name: positive regulation of cytotoxic T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of cytotoxic T cell differentiation" NARROW [] +synonym: "positive regulation of cytotoxic T cell development" RELATED [GOC:add] +synonym: "positive regulation of cytotoxic T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of cytotoxic T-cell differentiation" EXACT [] +synonym: "positive regulation of cytotoxic T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of cytotoxic T cell differentiation" NARROW [] +synonym: "up regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "up-regulation of cytotoxic T cell differentiation" EXACT [] +synonym: "upregulation of cytotoxic T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045583 ! regulation of cytotoxic T cell differentiation +relationship: positively_regulates GO:0045065 ! cytotoxic T cell differentiation + +[Term] +id: GO:0045586 +name: regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of gamma-delta T cell development" RELATED [GOC:add] +synonym: "regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +relationship: regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045587 +name: negative regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "down-regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "downregulation of gamma-delta T cell differentiation" EXACT [] +synonym: "inhibition of gamma-delta T cell differentiation" NARROW [] +synonym: "negative regulation of gamma-delta T cell development" RELATED [GOC:add] +synonym: "negative regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation +is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation +relationship: negatively_regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045588 +name: positive regulation of gamma-delta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of gamma-delta T cell differentiation" NARROW [] +synonym: "positive regulation of gamma-delta T cell development" RELATED [GOC:add] +synonym: "positive regulation of gamma-delta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell differentiation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of gamma-delta T cell differentiation" NARROW [] +synonym: "up regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "up-regulation of gamma-delta T cell differentiation" EXACT [] +synonym: "upregulation of gamma-delta T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045586 ! regulation of gamma-delta T cell differentiation +is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation +relationship: positively_regulates GO:0042492 ! gamma-delta T cell differentiation + +[Term] +id: GO:0045589 +name: regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of regulatory T cell development" RELATED [GOC:add] +synonym: "regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "regulation of regulatory T-cell differentiation" EXACT [] +synonym: "regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "regulation of suppressor T cell differentiation" EXACT [] +synonym: "regulation of suppressor T lymphocyte differentiation" EXACT [] +synonym: "regulation of suppressor T-cell differentiation" EXACT [] +synonym: "regulation of suppressor T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +relationship: regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045590 +name: negative regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of differentiation of regulatory T cells." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of regulatory T cell differentiation" EXACT [] +synonym: "down-regulation of regulatory T cell differentiation" EXACT [] +synonym: "downregulation of regulatory T cell differentiation" EXACT [] +synonym: "inhibition of regulatory T cell differentiation" NARROW [] +synonym: "negative regulation of regulatory T cell development" RELATED [GOC:add] +synonym: "negative regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of regulatory T-cell differentiation" EXACT [] +synonym: "negative regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of suppressor T cell differentiation" EXACT [] +synonym: "negative regulation of suppressor T-cell differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: negatively_regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045591 +name: positive regulation of regulatory T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells." [ISBN:0781735149] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of regulatory T cell differentiation" NARROW [] +synonym: "positive regulation of regulatory T cell development" RELATED [GOC:add] +synonym: "positive regulation of regulatory T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of regulatory T-cell differentiation" EXACT [] +synonym: "positive regulation of regulatory T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of suppressor T cell differentiation" EXACT [] +synonym: "positive regulation of suppressor T-cell differentiation" EXACT [] +synonym: "stimulation of regulatory T cell differentiation" NARROW [] +synonym: "up regulation of regulatory T cell differentiation" EXACT [] +synonym: "up-regulation of regulatory T cell differentiation" EXACT [] +synonym: "upregulation of regulatory T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0045589 ! regulation of regulatory T cell differentiation +relationship: positively_regulates GO:0045066 ! regulatory T cell differentiation + +[Term] +id: GO:0045592 +name: regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "regulation of ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:2000387 ! regulation of antral ovarian follicle growth +relationship: regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045593 +name: negative regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "down regulation of cumulus cell differentiation" EXACT [] +synonym: "down-regulation of cumulus cell differentiation" EXACT [] +synonym: "downregulation of cumulus cell differentiation" EXACT [] +synonym: "inhibition of cumulus cell differentiation" NARROW [] +synonym: "negative regulation of ovarian cumulus cell differentiation" EXACT [] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0045592 ! regulation of cumulus cell differentiation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045594 +name: positive regulation of cumulus cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ovarian cumulus cell differentiation." [GOC:go_curators] +synonym: "activation of cumulus cell differentiation" NARROW [] +synonym: "positive regulation of ovarian cumulus cell differentiation" EXACT [] +synonym: "stimulation of cumulus cell differentiation" NARROW [] +synonym: "up regulation of cumulus cell differentiation" EXACT [] +synonym: "up-regulation of cumulus cell differentiation" EXACT [] +synonym: "upregulation of cumulus cell differentiation" EXACT [] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0045592 ! regulation of cumulus cell differentiation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0001549 ! cumulus cell differentiation + +[Term] +id: GO:0045595 +name: regulation of cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045596 +name: negative regulation of cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation." [GOC:go_curators] +synonym: "down regulation of cell differentiation" EXACT [] +synonym: "down-regulation of cell differentiation" EXACT [] +synonym: "downregulation of cell differentiation" EXACT [] +synonym: "inhibition of cell differentiation" NARROW [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045597 +name: positive regulation of cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell differentiation." [GOC:go_curators] +synonym: "activation of cell differentiation" NARROW [] +synonym: "stimulation of cell differentiation" NARROW [] +synonym: "up regulation of cell differentiation" EXACT [] +synonym: "up-regulation of cell differentiation" EXACT [] +synonym: "upregulation of cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0030154 ! cell differentiation + +[Term] +id: GO:0045598 +name: regulation of fat cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "regulation of adipocyte cell differentiation" EXACT [] +synonym: "regulation of adipocyte differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045599 +name: negative regulation of fat cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "down regulation of fat cell differentiation" EXACT [] +synonym: "down-regulation of fat cell differentiation" EXACT [] +synonym: "downregulation of fat cell differentiation" EXACT [] +synonym: "inhibition of fat cell differentiation" NARROW [] +synonym: "negative regulation of adipocyte cell differentiation" EXACT [] +synonym: "negative regulation of adipocyte differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045598 ! regulation of fat cell differentiation +relationship: negatively_regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045600 +name: positive regulation of fat cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adipocyte differentiation." [GOC:go_curators] +synonym: "activation of fat cell differentiation" NARROW [] +synonym: "positive regulation of adipocyte cell differentiation" EXACT [] +synonym: "positive regulation of adipocyte differentiation" EXACT [] +synonym: "stimulation of fat cell differentiation" NARROW [] +synonym: "up regulation of fat cell differentiation" EXACT [] +synonym: "up-regulation of fat cell differentiation" EXACT [] +synonym: "upregulation of fat cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045598 ! regulation of fat cell differentiation +relationship: positively_regulates GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0045601 +name: regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045602 +name: negative regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +synonym: "down regulation of endothelial cell differentiation" EXACT [] +synonym: "down-regulation of endothelial cell differentiation" EXACT [] +synonym: "downregulation of endothelial cell differentiation" EXACT [] +synonym: "inhibition of endothelial cell differentiation" NARROW [] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0045601 ! regulation of endothelial cell differentiation +relationship: negatively_regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045603 +name: positive regulation of endothelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation." [GOC:go_curators] +synonym: "activation of endothelial cell differentiation" NARROW [] +synonym: "stimulation of endothelial cell differentiation" NARROW [] +synonym: "up regulation of endothelial cell differentiation" EXACT [] +synonym: "up-regulation of endothelial cell differentiation" EXACT [] +synonym: "upregulation of endothelial cell differentiation" EXACT [] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0045601 ! regulation of endothelial cell differentiation +relationship: positively_regulates GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0045604 +name: regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +synonym: "regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0045682 ! regulation of epidermis development +relationship: regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045605 +name: negative regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +synonym: "down regulation of epidermal cell differentiation" EXACT [] +synonym: "down-regulation of epidermal cell differentiation" EXACT [] +synonym: "downregulation of epidermal cell differentiation" EXACT [] +synonym: "inhibition of epidermal cell differentiation" NARROW [] +synonym: "negative regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0045604 ! regulation of epidermal cell differentiation +is_a: GO:0045683 ! negative regulation of epidermis development +relationship: negatively_regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045606 +name: positive regulation of epidermal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation." [GOC:go_curators] +synonym: "activation of epidermal cell differentiation" NARROW [] +synonym: "positive regulation of hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] +synonym: "stimulation of epidermal cell differentiation" NARROW [] +synonym: "up regulation of epidermal cell differentiation" EXACT [] +synonym: "up-regulation of epidermal cell differentiation" EXACT [] +synonym: "upregulation of epidermal cell differentiation" EXACT [] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0045604 ! regulation of epidermal cell differentiation +is_a: GO:0045684 ! positive regulation of epidermis development +relationship: positively_regulates GO:0009913 ! epidermal cell differentiation + +[Term] +id: GO:0045607 +name: regulation of inner ear auditory receptor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "regulation of auditory hair cell differentiation" EXACT [] +synonym: "regulation of auditory receptor cell differentiation" RELATED [] +is_a: GO:0045604 ! regulation of epidermal cell differentiation +is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation +relationship: regulates GO:0042491 ! inner ear auditory receptor cell differentiation + +[Term] +id: GO:0045608 +name: negative regulation of inner ear auditory receptor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "down regulation of auditory receptor cell differentiation" EXACT [] +synonym: "down-regulation of auditory receptor cell differentiation" EXACT [] +synonym: "downregulation of auditory receptor cell differentiation" EXACT [] +synonym: "inhibition of auditory receptor cell differentiation" NARROW [] +synonym: "negative regulation of auditory hair cell differentiation" EXACT [] +synonym: "negative regulation of auditory receptor cell differentiation" RELATED [] +is_a: GO:0045605 ! negative regulation of epidermal cell differentiation +is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation +is_a: GO:2000981 ! negative regulation of inner ear receptor cell differentiation +relationship: negatively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation + +[Term] +id: GO:0045609 +name: positive regulation of inner ear auditory receptor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of auditory hair cell differentiation." [GOC:go_curators] +synonym: "activation of auditory receptor cell differentiation" NARROW [] +synonym: "positive regulation of auditory hair cell differentiation" EXACT [] +synonym: "positive regulation of auditory receptor cell differentiation" RELATED [] +synonym: "stimulation of auditory receptor cell differentiation" NARROW [] +synonym: "up regulation of auditory receptor cell differentiation" EXACT [] +synonym: "up-regulation of auditory receptor cell differentiation" EXACT [] +synonym: "upregulation of auditory receptor cell differentiation" EXACT [] +is_a: GO:0045606 ! positive regulation of epidermal cell differentiation +is_a: GO:0045607 ! regulation of inner ear auditory receptor cell differentiation +is_a: GO:2000982 ! positive regulation of inner ear receptor cell differentiation +relationship: positively_regulates GO:0042491 ! inner ear auditory receptor cell differentiation + +[Term] +id: GO:0045610 +name: regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "regulation of arthropod blood cell differentiation" EXACT [] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045611 +name: negative regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "down regulation of hemocyte differentiation" EXACT [] +synonym: "down-regulation of hemocyte differentiation" EXACT [] +synonym: "downregulation of hemocyte differentiation" EXACT [] +synonym: "inhibition of hemocyte differentiation" NARROW [] +synonym: "negative regulation of arthropod blood cell differentiation" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: negatively_regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045612 +name: positive regulation of hemocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hemocyte differentiation." [GOC:go_curators] +synonym: "activation of hemocyte differentiation" NARROW [] +synonym: "positive regulation of arthropod blood cell differentiation" EXACT [] +synonym: "stimulation of hemocyte differentiation" NARROW [] +synonym: "up regulation of hemocyte differentiation" EXACT [] +synonym: "up-regulation of hemocyte differentiation" EXACT [] +synonym: "upregulation of hemocyte differentiation" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: positively_regulates GO:0042386 ! hemocyte differentiation + +[Term] +id: GO:0045613 +name: regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +is_a: GO:0045610 ! regulation of hemocyte differentiation +relationship: regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045614 +name: negative regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +synonym: "down regulation of plasmatocyte differentiation" EXACT [] +synonym: "down-regulation of plasmatocyte differentiation" EXACT [] +synonym: "downregulation of plasmatocyte differentiation" EXACT [] +synonym: "inhibition of plasmatocyte differentiation" NARROW [] +is_a: GO:0045611 ! negative regulation of hemocyte differentiation +is_a: GO:0045613 ! regulation of plasmatocyte differentiation +relationship: negatively_regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045615 +name: positive regulation of plasmatocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasmatocyte differentiation." [GOC:go_curators] +synonym: "activation of plasmatocyte differentiation" NARROW [] +synonym: "stimulation of plasmatocyte differentiation" NARROW [] +synonym: "up regulation of plasmatocyte differentiation" EXACT [] +synonym: "up-regulation of plasmatocyte differentiation" EXACT [] +synonym: "upregulation of plasmatocyte differentiation" EXACT [] +is_a: GO:0045612 ! positive regulation of hemocyte differentiation +is_a: GO:0045613 ! regulation of plasmatocyte differentiation +relationship: positively_regulates GO:0042387 ! plasmatocyte differentiation + +[Term] +id: GO:0045616 +name: regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +is_a: GO:0045604 ! regulation of epidermal cell differentiation +relationship: regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045617 +name: negative regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +synonym: "down regulation of keratinocyte differentiation" EXACT [] +synonym: "down-regulation of keratinocyte differentiation" EXACT [] +synonym: "downregulation of keratinocyte differentiation" EXACT [] +synonym: "inhibition of keratinocyte differentiation" NARROW [] +is_a: GO:0045605 ! negative regulation of epidermal cell differentiation +is_a: GO:0045616 ! regulation of keratinocyte differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045618 +name: positive regulation of keratinocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation." [GOC:go_curators] +synonym: "activation of keratinocyte differentiation" NARROW [] +synonym: "stimulation of keratinocyte differentiation" NARROW [] +synonym: "up regulation of keratinocyte differentiation" EXACT [] +synonym: "up-regulation of keratinocyte differentiation" EXACT [] +synonym: "upregulation of keratinocyte differentiation" EXACT [] +is_a: GO:0045606 ! positive regulation of epidermal cell differentiation +is_a: GO:0045616 ! regulation of keratinocyte differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0030216 ! keratinocyte differentiation + +[Term] +id: GO:0045619 +name: regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of lymphocyte development" RELATED [GOC:add] +is_a: GO:0051249 ! regulation of lymphocyte activation +is_a: GO:1902105 ! regulation of leukocyte differentiation +relationship: regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045620 +name: negative regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of lymphocyte differentiation" EXACT [] +synonym: "down-regulation of lymphocyte differentiation" EXACT [] +synonym: "downregulation of lymphocyte differentiation" EXACT [] +synonym: "inhibition of lymphocyte differentiation" NARROW [] +synonym: "negative regulation of lymphocyte development" RELATED [GOC:add] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +is_a: GO:1902106 ! negative regulation of leukocyte differentiation +relationship: negatively_regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045621 +name: positive regulation of lymphocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of lymphocyte differentiation" NARROW [] +synonym: "positive regulation of lymphocyte development" RELATED [GOC:add] +synonym: "stimulation of lymphocyte differentiation" NARROW [] +synonym: "up regulation of lymphocyte differentiation" EXACT [] +synonym: "up-regulation of lymphocyte differentiation" EXACT [] +synonym: "upregulation of lymphocyte differentiation" EXACT [] +is_a: GO:0045619 ! regulation of lymphocyte differentiation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +is_a: GO:1902107 ! positive regulation of leukocyte differentiation +relationship: positively_regulates GO:0030098 ! lymphocyte differentiation + +[Term] +id: GO:0045622 +name: regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of T-helper cell development" RELATED [GOC:add] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045623 +name: negative regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of T-helper cell differentiation" EXACT [] +synonym: "down-regulation of T-helper cell differentiation" EXACT [] +synonym: "downregulation of T-helper cell differentiation" EXACT [] +synonym: "inhibition of T-helper cell differentiation" NARROW [] +synonym: "negative regulation of T-helper cell development" RELATED [GOC:add] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045622 ! regulation of T-helper cell differentiation +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045624 +name: positive regulation of T-helper cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of T-helper cell differentiation" NARROW [] +synonym: "positive regulation of T-helper cell development" RELATED [GOC:add] +synonym: "stimulation of T-helper cell differentiation" NARROW [] +synonym: "up regulation of T-helper cell differentiation" EXACT [] +synonym: "up-regulation of T-helper cell differentiation" EXACT [] +synonym: "upregulation of T-helper cell differentiation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation +is_a: GO:0045622 ! regulation of T-helper cell differentiation +is_a: GO:0050778 ! positive regulation of immune response +relationship: positively_regulates GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0045625 +name: regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of T-helper 1 cell development" RELATED [GOC:add] +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045626 +name: negative regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "down-regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "downregulation of T-helper 1 cell differentiation" EXACT [] +synonym: "inhibition of T-helper 1 cell differentiation" NARROW [] +synonym: "negative regulation of T-helper 1 cell development" RELATED [GOC:add] +is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response +is_a: GO:0045623 ! negative regulation of T-helper cell differentiation +is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation +relationship: negatively_regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045627 +name: positive regulation of T-helper 1 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of T-helper 1 cell differentiation" NARROW [] +synonym: "positive regulation of T-helper 1 cell development" RELATED [GOC:add] +synonym: "stimulation of T-helper 1 cell differentiation" NARROW [] +synonym: "up regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "up-regulation of T-helper 1 cell differentiation" EXACT [] +synonym: "upregulation of T-helper 1 cell differentiation" EXACT [] +is_a: GO:0045624 ! positive regulation of T-helper cell differentiation +is_a: GO:0045625 ! regulation of T-helper 1 cell differentiation +relationship: positively_regulates GO:0045063 ! T-helper 1 cell differentiation + +[Term] +id: GO:0045628 +name: regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of T-helper 2 cell development" RELATED [GOC:add] +is_a: GO:0002828 ! regulation of type 2 immune response +is_a: GO:0045622 ! regulation of T-helper cell differentiation +relationship: regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045629 +name: negative regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "down-regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "downregulation of T-helper 2 cell differentiation" EXACT [] +synonym: "inhibition of T-helper 2 cell differentiation" NARROW [] +synonym: "negative regulation of T-helper 2 cell development" RELATED [GOC:add] +is_a: GO:0002829 ! negative regulation of type 2 immune response +is_a: GO:0045623 ! negative regulation of T-helper cell differentiation +is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation +relationship: negatively_regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045630 +name: positive regulation of T-helper 2 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation." [GOC:go_curators] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of T-helper 2 cell differentiation" NARROW [] +synonym: "positive regulation of T-helper 2 cell development" RELATED [GOC:add] +synonym: "stimulation of T-helper 2 cell differentiation" NARROW [] +synonym: "up regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "up-regulation of T-helper 2 cell differentiation" EXACT [] +synonym: "upregulation of T-helper 2 cell differentiation" EXACT [] +is_a: GO:0002830 ! positive regulation of type 2 immune response +is_a: GO:0045624 ! positive regulation of T-helper cell differentiation +is_a: GO:0045628 ! regulation of T-helper 2 cell differentiation +relationship: positively_regulates GO:0045064 ! T-helper 2 cell differentiation + +[Term] +id: GO:0045631 +name: regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045632 +name: negative regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +synonym: "down regulation of mechanoreceptor differentiation" EXACT [] +synonym: "down-regulation of mechanoreceptor differentiation" EXACT [] +synonym: "downregulation of mechanoreceptor differentiation" EXACT [] +synonym: "inhibition of mechanoreceptor differentiation" NARROW [] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +is_a: GO:0045665 ! negative regulation of neuron differentiation +relationship: negatively_regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045633 +name: positive regulation of mechanoreceptor differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mechanoreceptor differentiation." [GOC:go_curators] +synonym: "activation of mechanoreceptor differentiation" NARROW [] +synonym: "stimulation of mechanoreceptor differentiation" NARROW [] +synonym: "up regulation of mechanoreceptor differentiation" EXACT [] +synonym: "up-regulation of mechanoreceptor differentiation" EXACT [] +synonym: "upregulation of mechanoreceptor differentiation" EXACT [] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +is_a: GO:0045666 ! positive regulation of neuron differentiation +relationship: positively_regulates GO:0042490 ! mechanoreceptor differentiation + +[Term] +id: GO:0045634 +name: regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "regulation of melanophore differentiation" EXACT [] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045635 +name: negative regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "down regulation of melanocyte differentiation" EXACT [] +synonym: "down-regulation of melanocyte differentiation" EXACT [] +synonym: "downregulation of melanocyte differentiation" EXACT [] +synonym: "inhibition of melanocyte differentiation" NARROW [] +synonym: "negative regulation of melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045636 +name: positive regulation of melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of melanocyte differentiation." [GOC:go_curators] +synonym: "activation of melanocyte differentiation" NARROW [] +synonym: "positive regulation of melanophore differentiation" EXACT [] +synonym: "stimulation of melanocyte differentiation" NARROW [] +synonym: "up regulation of melanocyte differentiation" EXACT [] +synonym: "up-regulation of melanocyte differentiation" EXACT [] +synonym: "upregulation of melanocyte differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0045637 +name: regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:1903706 ! regulation of hemopoiesis +relationship: regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045638 +name: negative regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +synonym: "down regulation of myeloid cell differentiation" EXACT [] +synonym: "down-regulation of myeloid cell differentiation" EXACT [] +synonym: "downregulation of myeloid cell differentiation" EXACT [] +synonym: "inhibition of myeloid cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: negatively_regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045639 +name: positive regulation of myeloid cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation." [GOC:go_curators] +synonym: "activation of myeloid cell differentiation" NARROW [] +synonym: "stimulation of myeloid cell differentiation" NARROW [] +synonym: "up regulation of myeloid cell differentiation" EXACT [] +synonym: "up-regulation of myeloid cell differentiation" EXACT [] +synonym: "upregulation of myeloid cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: positively_regulates GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0045640 +name: regulation of basophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045641 +name: negative regulation of basophil differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +synonym: "down regulation of basophil differentiation" EXACT [] +synonym: "down-regulation of basophil differentiation" EXACT [] +synonym: "downregulation of basophil differentiation" EXACT [] +synonym: "inhibition of basophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +relationship: negatively_regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045642 +name: positive regulation of basophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of basophil differentiation." [GOC:go_curators] +synonym: "activation of basophil differentiation" NARROW [] +synonym: "stimulation of basophil differentiation" NARROW [] +synonym: "up regulation of basophil differentiation" EXACT [] +synonym: "up-regulation of basophil differentiation" EXACT [] +synonym: "upregulation of basophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045640 ! regulation of basophil differentiation +relationship: positively_regulates GO:0030221 ! basophil differentiation + +[Term] +id: GO:0045643 +name: regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045644 +name: negative regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +synonym: "down regulation of eosinophil differentiation" EXACT [] +synonym: "down-regulation of eosinophil differentiation" EXACT [] +synonym: "downregulation of eosinophil differentiation" EXACT [] +synonym: "inhibition of eosinophil differentiation" NARROW [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045643 ! regulation of eosinophil differentiation +relationship: negatively_regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045645 +name: positive regulation of eosinophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil differentiation." [GOC:go_curators] +synonym: "activation of eosinophil differentiation" NARROW [] +synonym: "stimulation of eosinophil differentiation" NARROW [] +synonym: "up regulation of eosinophil differentiation" EXACT [] +synonym: "up-regulation of eosinophil differentiation" EXACT [] +synonym: "upregulation of eosinophil differentiation" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045643 ! regulation of eosinophil differentiation +relationship: positively_regulates GO:0030222 ! eosinophil differentiation + +[Term] +id: GO:0045646 +name: regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +synonym: "regulation of RBC differentiation" EXACT [CL:0000232] +synonym: "regulation of red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045647 +name: negative regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +synonym: "down regulation of erythrocyte differentiation" EXACT [] +synonym: "down-regulation of erythrocyte differentiation" EXACT [] +synonym: "downregulation of erythrocyte differentiation" EXACT [] +synonym: "inhibition of erythrocyte differentiation" NARROW [] +synonym: "negative regulation of RBC differentiation" EXACT [CL:0000232] +synonym: "negative regulation of red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: negatively_regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045648 +name: positive regulation of erythrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation." [GOC:go_curators] +synonym: "activation of erythrocyte differentiation" NARROW [] +synonym: "positive regulation of RBC differentiation" EXACT [CL:0000232] +synonym: "positive regulation of red blood cell differentiation" EXACT [CL:0000232] +synonym: "stimulation of erythrocyte differentiation" NARROW [] +synonym: "up regulation of erythrocyte differentiation" EXACT [] +synonym: "up-regulation of erythrocyte differentiation" EXACT [] +synonym: "upregulation of erythrocyte differentiation" EXACT [] +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:0045646 ! regulation of erythrocyte differentiation +relationship: positively_regulates GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0045649 +name: regulation of macrophage differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045650 +name: negative regulation of macrophage differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +synonym: "down regulation of macrophage differentiation" EXACT [] +synonym: "down-regulation of macrophage differentiation" EXACT [] +synonym: "downregulation of macrophage differentiation" EXACT [] +synonym: "inhibition of macrophage differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045649 ! regulation of macrophage differentiation +relationship: negatively_regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045651 +name: positive regulation of macrophage differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage differentiation." [GOC:go_curators] +synonym: "activation of macrophage differentiation" NARROW [] +synonym: "stimulation of macrophage differentiation" NARROW [] +synonym: "up regulation of macrophage differentiation" EXACT [] +synonym: "up-regulation of macrophage differentiation" EXACT [] +synonym: "upregulation of macrophage differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045649 ! regulation of macrophage differentiation +relationship: positively_regulates GO:0030225 ! macrophage differentiation + +[Term] +id: GO:0045652 +name: regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045653 +name: negative regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +synonym: "down regulation of megakaryocyte differentiation" EXACT [] +synonym: "down-regulation of megakaryocyte differentiation" EXACT [] +synonym: "downregulation of megakaryocyte differentiation" EXACT [] +synonym: "inhibition of megakaryocyte differentiation" NARROW [] +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:0045652 ! regulation of megakaryocyte differentiation +relationship: negatively_regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045654 +name: positive regulation of megakaryocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation." [GOC:go_curators] +synonym: "activation of megakaryocyte differentiation" NARROW [] +synonym: "stimulation of megakaryocyte differentiation" NARROW [] +synonym: "up regulation of megakaryocyte differentiation" EXACT [] +synonym: "up-regulation of megakaryocyte differentiation" EXACT [] +synonym: "upregulation of megakaryocyte differentiation" EXACT [] +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:0045652 ! regulation of megakaryocyte differentiation +relationship: positively_regulates GO:0030219 ! megakaryocyte differentiation + +[Term] +id: GO:0045655 +name: regulation of monocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045656 +name: negative regulation of monocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +synonym: "down regulation of monocyte differentiation" EXACT [] +synonym: "down-regulation of monocyte differentiation" EXACT [] +synonym: "downregulation of monocyte differentiation" EXACT [] +synonym: "inhibition of monocyte differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045655 ! regulation of monocyte differentiation +relationship: negatively_regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045657 +name: positive regulation of monocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monocyte differentiation." [GOC:go_curators] +synonym: "activation of monocyte differentiation" NARROW [] +synonym: "stimulation of monocyte differentiation" NARROW [] +synonym: "up regulation of monocyte differentiation" EXACT [] +synonym: "up-regulation of monocyte differentiation" EXACT [] +synonym: "upregulation of monocyte differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045655 ! regulation of monocyte differentiation +relationship: positively_regulates GO:0030224 ! monocyte differentiation + +[Term] +id: GO:0045658 +name: regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +is_a: GO:0030852 ! regulation of granulocyte differentiation +relationship: regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045659 +name: negative regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +synonym: "down regulation of neutrophil differentiation" EXACT [] +synonym: "down-regulation of neutrophil differentiation" EXACT [] +synonym: "downregulation of neutrophil differentiation" EXACT [] +synonym: "inhibition of neutrophil differentiation" NARROW [] +is_a: GO:0030853 ! negative regulation of granulocyte differentiation +is_a: GO:0045658 ! regulation of neutrophil differentiation +relationship: negatively_regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045660 +name: positive regulation of neutrophil differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil differentiation." [GOC:go_curators] +synonym: "activation of neutrophil differentiation" NARROW [] +synonym: "stimulation of neutrophil differentiation" NARROW [] +synonym: "up regulation of neutrophil differentiation" EXACT [] +synonym: "up-regulation of neutrophil differentiation" EXACT [] +synonym: "upregulation of neutrophil differentiation" EXACT [] +is_a: GO:0030854 ! positive regulation of granulocyte differentiation +is_a: GO:0045658 ! regulation of neutrophil differentiation +relationship: positively_regulates GO:0030223 ! neutrophil differentiation + +[Term] +id: GO:0045661 +name: regulation of myoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045662 +name: negative regulation of myoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +synonym: "down regulation of myoblast differentiation" EXACT [] +synonym: "down-regulation of myoblast differentiation" EXACT [] +synonym: "downregulation of myoblast differentiation" EXACT [] +synonym: "inhibition of myoblast differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045661 ! regulation of myoblast differentiation +relationship: negatively_regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045663 +name: positive regulation of myoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators, GOC:mtg_muscle] +synonym: "activation of myoblast differentiation" NARROW [] +synonym: "stimulation of myoblast differentiation" NARROW [] +synonym: "up regulation of myoblast differentiation" EXACT [] +synonym: "up-regulation of myoblast differentiation" EXACT [] +synonym: "upregulation of myoblast differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045661 ! regulation of myoblast differentiation +relationship: positively_regulates GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0045664 +name: regulation of neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045665 +name: negative regulation of neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +synonym: "down regulation of neuron differentiation" EXACT [] +synonym: "down-regulation of neuron differentiation" EXACT [] +synonym: "downregulation of neuron differentiation" EXACT [] +synonym: "inhibition of neuron differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: negatively_regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045666 +name: positive regulation of neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron differentiation." [GOC:go_curators] +synonym: "activation of neuron differentiation" NARROW [] +synonym: "stimulation of neuron differentiation" NARROW [] +synonym: "up regulation of neuron differentiation" EXACT [] +synonym: "up-regulation of neuron differentiation" EXACT [] +synonym: "upregulation of neuron differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: positively_regulates GO:0030182 ! neuron differentiation + +[Term] +id: GO:0045667 +name: regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045668 +name: negative regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +synonym: "down regulation of osteoblast differentiation" EXACT [] +synonym: "down-regulation of osteoblast differentiation" EXACT [] +synonym: "downregulation of osteoblast differentiation" EXACT [] +synonym: "inhibition of osteoblast differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045667 ! regulation of osteoblast differentiation +relationship: negatively_regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045669 +name: positive regulation of osteoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osteoblast differentiation." [GOC:go_curators] +synonym: "activation of osteoblast differentiation" NARROW [] +synonym: "stimulation of osteoblast differentiation" NARROW [] +synonym: "up regulation of osteoblast differentiation" EXACT [] +synonym: "up-regulation of osteoblast differentiation" EXACT [] +synonym: "upregulation of osteoblast differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045667 ! regulation of osteoblast differentiation +relationship: positively_regulates GO:0001649 ! osteoblast differentiation + +[Term] +id: GO:0045670 +name: regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045671 +name: negative regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +synonym: "down regulation of osteoclast differentiation" EXACT [] +synonym: "down-regulation of osteoclast differentiation" EXACT [] +synonym: "downregulation of osteoclast differentiation" EXACT [] +synonym: "inhibition of osteoclast differentiation" NARROW [] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0045670 ! regulation of osteoclast differentiation +relationship: negatively_regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045672 +name: positive regulation of osteoclast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osteoclast differentiation." [GOC:go_curators] +synonym: "activation of osteoclast differentiation" NARROW [] +synonym: "stimulation of osteoclast differentiation" NARROW [] +synonym: "up regulation of osteoclast differentiation" EXACT [] +synonym: "up-regulation of osteoclast differentiation" EXACT [] +synonym: "upregulation of osteoclast differentiation" EXACT [] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0045670 ! regulation of osteoclast differentiation +relationship: positively_regulates GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0045676 +name: regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of R7 differentiation." [GOC:go_curators] +is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation +relationship: regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045677 +name: negative regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of R7 differentiation" EXACT [] +synonym: "down-regulation of R7 differentiation" EXACT [] +synonym: "downregulation of R7 differentiation" EXACT [] +synonym: "inhibition of R7 differentiation" NARROW [] +synonym: "negative regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045676 ! regulation of R7 cell differentiation +is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation +relationship: negatively_regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045678 +name: positive regulation of R7 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of R7 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R7 differentiation" NARROW [] +synonym: "positive regulation of R7 differentiation" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R7 differentiation" NARROW [] +synonym: "up regulation of R7 differentiation" EXACT [] +synonym: "up-regulation of R7 differentiation" EXACT [] +synonym: "upregulation of R7 differentiation" EXACT [] +is_a: GO:0045676 ! regulation of R7 cell differentiation +is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation +relationship: positively_regulates GO:0045466 ! R7 cell differentiation + +[Term] +id: GO:0045679 +name: regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of R8 differentiation." [GOC:go_curators] +is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation +relationship: regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045680 +name: negative regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of R8 differentiation" EXACT [] +synonym: "down-regulation of R8 differentiation" EXACT [] +synonym: "downregulation of R8 differentiation" EXACT [] +synonym: "inhibition of R8 differentiation" NARROW [] +synonym: "negative regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045679 ! regulation of R8 cell differentiation +is_a: GO:0110118 ! negative regulation of compound eye photoreceptor cell differentiation +relationship: negatively_regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045681 +name: positive regulation of R8 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of R8 cell differentiation." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R8 differentiation" NARROW [] +synonym: "positive regulation of R8 differentiation" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R8 differentiation" NARROW [] +synonym: "up regulation of R8 differentiation" EXACT [] +synonym: "up-regulation of R8 differentiation" EXACT [] +synonym: "upregulation of R8 differentiation" EXACT [] +is_a: GO:0045679 ! regulation of R8 cell differentiation +is_a: GO:0110117 ! positive regulation of compound eye photoreceptor cell differentiation +relationship: positively_regulates GO:0045465 ! R8 cell differentiation + +[Term] +id: GO:0045682 +name: regulation of epidermis development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "regulation of epidermal development" EXACT [] +synonym: "regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045683 +name: negative regulation of epidermis development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "down regulation of epidermis development" EXACT [] +synonym: "down-regulation of epidermis development" EXACT [] +synonym: "downregulation of epidermis development" EXACT [] +synonym: "inhibition of epidermis development" NARROW [] +synonym: "negative regulation of epidermal development" EXACT [] +synonym: "negative regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0045682 ! regulation of epidermis development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045684 +name: positive regulation of epidermis development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermis development." [GOC:go_curators] +synonym: "activation of epidermis development" NARROW [] +synonym: "positive regulation of epidermal development" EXACT [] +synonym: "positive regulation of hypodermis development" RELATED [GOC:kmv, GOC:rk] +synonym: "stimulation of epidermis development" NARROW [] +synonym: "up regulation of epidermis development" EXACT [] +synonym: "up-regulation of epidermis development" EXACT [] +synonym: "upregulation of epidermis development" EXACT [] +is_a: GO:0045682 ! regulation of epidermis development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0008544 ! epidermis development + +[Term] +id: GO:0045685 +name: regulation of glial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "regulation of glia cell differentiation" EXACT [] +synonym: "regulation of neuroglia differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045686 +name: negative regulation of glial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "down regulation of glial cell differentiation" EXACT [] +synonym: "down-regulation of glial cell differentiation" EXACT [] +synonym: "downregulation of glial cell differentiation" EXACT [] +synonym: "inhibition of glial cell differentiation" NARROW [] +synonym: "negative regulation of glia cell differentiation" EXACT [] +synonym: "negative regulation of neuroglia differentiation" EXACT [] +is_a: GO:0014014 ! negative regulation of gliogenesis +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: negatively_regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045687 +name: positive regulation of glial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glia cell differentiation." [GOC:go_curators] +synonym: "activation of glial cell differentiation" NARROW [] +synonym: "positive regulation of glia cell differentiation" EXACT [] +synonym: "positive regulation of neuroglia differentiation" EXACT [] +synonym: "stimulation of glial cell differentiation" NARROW [] +synonym: "up regulation of glial cell differentiation" EXACT [] +synonym: "up-regulation of glial cell differentiation" EXACT [] +synonym: "upregulation of glial cell differentiation" EXACT [] +is_a: GO:0014015 ! positive regulation of gliogenesis +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: positively_regulates GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0045688 +name: regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045689 +name: negative regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of antipodal cell differentiation" EXACT [] +synonym: "down-regulation of antipodal cell differentiation" EXACT [] +synonym: "downregulation of antipodal cell differentiation" EXACT [] +synonym: "inhibition of antipodal cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045688 ! regulation of antipodal cell differentiation +relationship: negatively_regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045690 +name: positive regulation of antipodal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of antipodal cell differentiation" NARROW [] +synonym: "stimulation of antipodal cell differentiation" NARROW [] +synonym: "up regulation of antipodal cell differentiation" EXACT [] +synonym: "up-regulation of antipodal cell differentiation" EXACT [] +synonym: "upregulation of antipodal cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045688 ! regulation of antipodal cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009557 ! antipodal cell differentiation + +[Term] +id: GO:0045691 +name: regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "regulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045692 +name: negative regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "down-regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "downregulation of female gametophyte central cell differentiation" EXACT [] +synonym: "inhibition of female gametophyte central cell differentiation" NARROW [] +synonym: "negative regulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045691 ! regulation of embryo sac central cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045693 +name: positive regulation of embryo sac central cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of female gametophyte central cell differentiation" NARROW [] +synonym: "positive regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "stimulation of female gametophyte central cell differentiation" NARROW [] +synonym: "up regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "up-regulation of female gametophyte central cell differentiation" EXACT [] +synonym: "upregulation of female gametophyte central cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045691 ! regulation of embryo sac central cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009559 ! embryo sac central cell differentiation + +[Term] +id: GO:0045694 +name: regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "regulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045695 +name: negative regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "down regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "down-regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "downregulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "inhibition of female gametophyte egg cell differentiation" NARROW [] +synonym: "negative regulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045696 +name: positive regulation of embryo sac egg cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation." [GOC:go_curators, GOC:mtg_plant] +synonym: "activation of female gametophyte egg cell differentiation" NARROW [] +synonym: "positive regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "stimulation of female gametophyte egg cell differentiation" NARROW [] +synonym: "up regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "up-regulation of female gametophyte egg cell differentiation" EXACT [] +synonym: "upregulation of female gametophyte egg cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045694 ! regulation of embryo sac egg cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0009560 ! embryo sac egg cell differentiation + +[Term] +id: GO:0045697 +name: regulation of synergid differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "regulation of synergid cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045698 +name: negative regulation of synergid differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "down regulation of synergid differentiation" EXACT [] +synonym: "down-regulation of synergid differentiation" EXACT [] +synonym: "downregulation of synergid differentiation" EXACT [] +synonym: "inhibition of synergid differentiation" NARROW [] +synonym: "negative regulation of synergid cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045697 ! regulation of synergid differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045699 +name: positive regulation of synergid differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synergid cell differentiation." [GOC:go_curators] +synonym: "activation of synergid differentiation" NARROW [] +synonym: "positive regulation of synergid cell differentiation" EXACT [] +synonym: "stimulation of synergid differentiation" NARROW [] +synonym: "up regulation of synergid differentiation" EXACT [] +synonym: "up-regulation of synergid differentiation" EXACT [] +synonym: "upregulation of synergid differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045697 ! regulation of synergid differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009563 ! synergid differentiation + +[Term] +id: GO:0045700 +name: regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:1903353 ! regulation of nucleus organization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045701 +name: negative regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +synonym: "down regulation of spermatid nuclear differentiation" EXACT [] +synonym: "down-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "downregulation of spermatid nuclear differentiation" EXACT [] +synonym: "inhibition of spermatid nuclear differentiation" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045702 +name: positive regulation of spermatid nuclear differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation." [GOC:go_curators] +synonym: "activation of spermatid nuclear differentiation" NARROW [] +synonym: "stimulation of spermatid nuclear differentiation" NARROW [] +synonym: "up regulation of spermatid nuclear differentiation" EXACT [] +synonym: "up-regulation of spermatid nuclear differentiation" EXACT [] +synonym: "upregulation of spermatid nuclear differentiation" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0045700 ! regulation of spermatid nuclear differentiation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0007289 ! spermatid nucleus differentiation + +[Term] +id: GO:0045703 +name: ketoreductase activity +namespace: molecular_function +def: "Catalysis of the reduction of a ketone group to form the corresponding alcohol." [GOC:curators] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0045704 +name: regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "regulation of salivary gland determination" EXACT [GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045705 +name: negative regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "down regulation of salivary gland determination" EXACT [] +synonym: "down-regulation of salivary gland determination" EXACT [] +synonym: "downregulation of salivary gland determination" EXACT [] +synonym: "inhibition of salivary gland determination" NARROW [] +synonym: "negative regulation of salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045706 +name: positive regulation of salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination." [GOC:go_curators, GOC:tb] +synonym: "activation of salivary gland determination" NARROW [] +synonym: "positive regulation of salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of salivary gland determination" NARROW [] +synonym: "up regulation of salivary gland determination" EXACT [] +synonym: "up-regulation of salivary gland determination" EXACT [] +synonym: "upregulation of salivary gland determination" EXACT [] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007432 ! salivary gland boundary specification + +[Term] +id: GO:0045707 +name: regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "regulation of adult salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +relationship: regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045708 +name: regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "regulation of larval salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045704 ! regulation of salivary gland boundary specification +relationship: regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045709 +name: negative regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "down regulation of adult salivary gland determination" EXACT [] +synonym: "down-regulation of adult salivary gland determination" EXACT [] +synonym: "downregulation of adult salivary gland determination" EXACT [] +synonym: "inhibition of adult salivary gland determination" NARROW [] +synonym: "negative regulation of adult salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045705 ! negative regulation of salivary gland boundary specification +is_a: GO:0045707 ! regulation of adult salivary gland boundary specification +relationship: negatively_regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045710 +name: negative regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "down regulation of larval salivary gland determination" EXACT [] +synonym: "down-regulation of larval salivary gland determination" EXACT [] +synonym: "downregulation of larval salivary gland determination" EXACT [] +synonym: "inhibition of larval salivary gland determination" NARROW [] +synonym: "negative regulation of larval salivary gland determination" EXACT [GOC:tb] +is_a: GO:0045705 ! negative regulation of salivary gland boundary specification +is_a: GO:0045708 ! regulation of larval salivary gland boundary specification +relationship: negatively_regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045711 +name: positive regulation of adult salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in an adult organism." [GOC:go_curators, GOC:tb] +synonym: "activation of adult salivary gland determination" NARROW [] +synonym: "positive regulation of adult salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of adult salivary gland determination" NARROW [] +synonym: "up regulation of adult salivary gland determination" EXACT [] +synonym: "up-regulation of adult salivary gland determination" EXACT [] +synonym: "upregulation of adult salivary gland determination" EXACT [] +is_a: GO:0045706 ! positive regulation of salivary gland boundary specification +is_a: GO:0045707 ! regulation of adult salivary gland boundary specification +relationship: positively_regulates GO:0007434 ! adult salivary gland boundary specification + +[Term] +id: GO:0045712 +name: positive regulation of larval salivary gland boundary specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salivary gland determination in a larval organism." [GOC:go_curators, GOC:tb] +synonym: "activation of larval salivary gland determination" NARROW [] +synonym: "positive regulation of larval salivary gland determination" EXACT [GOC:tb] +synonym: "stimulation of larval salivary gland determination" NARROW [] +synonym: "up regulation of larval salivary gland determination" EXACT [] +synonym: "up-regulation of larval salivary gland determination" EXACT [] +synonym: "upregulation of larval salivary gland determination" EXACT [] +is_a: GO:0045706 ! positive regulation of salivary gland boundary specification +is_a: GO:0045708 ! regulation of larval salivary gland boundary specification +relationship: positively_regulates GO:0007433 ! larval salivary gland boundary specification + +[Term] +id: GO:0045713 +name: obsolete low-density lipoprotein particle receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors, cell surface proteins that mediate the endocytosis of low-density lipoprotein particles by cells." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "LDLr biosynthesis" EXACT [] +synonym: "LDLr biosynthetic process" EXACT [] +synonym: "low-density lipoprotein receptor anabolism" EXACT [] +synonym: "low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] +synonym: "low-density lipoprotein receptor formation" EXACT [] +synonym: "low-density lipoprotein receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045714 +name: obsolete regulation of low-density lipoprotein particle receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "regulation of LDLr biosynthesis" EXACT [] +synonym: "regulation of LDLr biosynthetic process" EXACT [] +synonym: "regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] +synonym: "regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "regulation of low-density lipoprotein receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045715 +name: obsolete negative regulation of low-density lipoprotein particle receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "down regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "down-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "downregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "inhibition of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "negative regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] +synonym: "negative regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "negative regulation of low-density lipoprotein receptor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045716 +name: obsolete positive regulation of low-density lipoprotein particle receptor biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein receptors." [GOC:go_curators] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "activation of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "positive regulation of low-density lipoprotein receptor anabolism" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor biosynthesis" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor biosynthetic process" EXACT [GOC:dph] +synonym: "positive regulation of low-density lipoprotein receptor formation" EXACT [] +synonym: "positive regulation of low-density lipoprotein receptor synthesis" EXACT [] +synonym: "stimulation of low-density lipoprotein receptor biosynthetic process" NARROW [] +synonym: "up regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "up-regulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +synonym: "upregulation of low-density lipoprotein receptor biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045717 +name: negative regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] +synonym: "down regulation of fatty acid biosynthetic process" EXACT [] +synonym: "down-regulation of fatty acid biosynthetic process" EXACT [] +synonym: "downregulation of fatty acid biosynthetic process" EXACT [] +synonym: "inhibition of fatty acid biosynthetic process" NARROW [] +synonym: "negative regulation of fatty acid anabolism" EXACT [] +synonym: "negative regulation of fatty acid biosynthesis" EXACT [] +synonym: "negative regulation of fatty acid formation" EXACT [] +synonym: "negative regulation of fatty acid synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0045718 +name: obsolete negative regulation of flagellum assembly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "down regulation of flagellum assembly" EXACT [] +synonym: "down-regulation of flagellum assembly" EXACT [] +synonym: "downregulation of flagellum assembly" EXACT [] +synonym: "inhibition of flagellum assembly" NARROW [] +synonym: "negative regulation of flagella assembly" EXACT [] +synonym: "negative regulation of flagellum assembly" EXACT [] +synonym: "negative regulation of flagellum biogenesis" RELATED [GOC:mah] +is_obsolete: true +consider: GO:1902018 + +[Term] +id: GO:0045719 +name: negative regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "down regulation of glycogen biosynthetic process" EXACT [] +synonym: "down-regulation of glycogen biosynthetic process" EXACT [] +synonym: "downregulation of glycogen biosynthetic process" EXACT [] +synonym: "inhibition of glycogen biosynthetic process" NARROW [] +synonym: "negative regulation of glycogen anabolism" EXACT [] +synonym: "negative regulation of glycogen biosynthesis" EXACT [] +synonym: "negative regulation of glycogen formation" EXACT [] +synonym: "negative regulation of glycogen synthesis" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0070874 ! negative regulation of glycogen metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0045720 +name: negative regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "down regulation of integrin biosynthetic process" EXACT [] +synonym: "down-regulation of integrin biosynthetic process" EXACT [] +synonym: "downregulation of integrin biosynthetic process" EXACT [] +synonym: "inhibition of integrin biosynthetic process" NARROW [] +synonym: "negative regulation of integrin anabolism" EXACT [] +synonym: "negative regulation of integrin biosynthesis" EXACT [] +synonym: "negative regulation of integrin formation" EXACT [] +synonym: "negative regulation of integrin synthesis" EXACT [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045113 ! regulation of integrin biosynthetic process +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045721 +name: negative regulation of gluconeogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] +synonym: "down regulation of gluconeogenesis" EXACT [] +synonym: "down-regulation of gluconeogenesis" EXACT [] +synonym: "downregulation of gluconeogenesis" EXACT [] +synonym: "inhibition of gluconeogenesis" NARROW [] +is_a: GO:0006111 ! regulation of gluconeogenesis +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0045722 +name: positive regulation of gluconeogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gluconeogenesis." [GOC:go_curators] +synonym: "activation of gluconeogenesis" NARROW [] +synonym: "stimulation of gluconeogenesis" NARROW [] +synonym: "up regulation of gluconeogenesis" EXACT [] +synonym: "up-regulation of gluconeogenesis" EXACT [] +synonym: "upregulation of gluconeogenesis" EXACT [] +is_a: GO:0006111 ! regulation of gluconeogenesis +is_a: GO:0010907 ! positive regulation of glucose metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0006094 ! gluconeogenesis + +[Term] +id: GO:0045723 +name: positive regulation of fatty acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids." [GOC:go_curators] +synonym: "activation of fatty acid biosynthetic process" NARROW [] +synonym: "positive regulation of fatty acid anabolism" EXACT [] +synonym: "positive regulation of fatty acid biosynthesis" EXACT [] +synonym: "positive regulation of fatty acid formation" EXACT [] +synonym: "positive regulation of fatty acid synthesis" EXACT [] +synonym: "stimulation of fatty acid biosynthetic process" NARROW [] +synonym: "up regulation of fatty acid biosynthetic process" EXACT [] +synonym: "up-regulation of fatty acid biosynthetic process" EXACT [] +synonym: "upregulation of fatty acid biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0045724 +name: positive regulation of cilium assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation of a cilium." [GOC:cilia, GOC:go_curators] +synonym: "activation of cilium assembly" NARROW [] +synonym: "positive regulation of flagellum assembly" BROAD [] +synonym: "positive regulation of flagellum biogenesis" RELATED [GOC:mah] +synonym: "stimulation of cilium assembly" NARROW [] +synonym: "up regulation of cilium assembly" EXACT [] +synonym: "up-regulation of cilium assembly" EXACT [] +synonym: "upregulation of cilium assembly" EXACT [] +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902017 ! regulation of cilium assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0060271 ! cilium assembly + +[Term] +id: GO:0045725 +name: positive regulation of glycogen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] +synonym: "activation of glycogen biosynthetic process" NARROW [] +synonym: "positive regulation of glycogen anabolism" EXACT [] +synonym: "positive regulation of glycogen biosynthesis" EXACT [] +synonym: "positive regulation of glycogen formation" EXACT [] +synonym: "positive regulation of glycogen synthesis" EXACT [] +synonym: "stimulation of glycogen biosynthetic process" NARROW [] +synonym: "up regulation of glycogen biosynthetic process" EXACT [] +synonym: "up-regulation of glycogen biosynthetic process" EXACT [] +synonym: "upregulation of glycogen biosynthetic process" EXACT [] +is_a: GO:0005979 ! regulation of glycogen biosynthetic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0070875 ! positive regulation of glycogen metabolic process +relationship: positively_regulates GO:0005978 ! glycogen biosynthetic process + +[Term] +id: GO:0045726 +name: positive regulation of integrin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators] +synonym: "activation of integrin biosynthetic process" NARROW [] +synonym: "positive regulation of integrin anabolism" EXACT [] +synonym: "positive regulation of integrin biosynthesis" EXACT [] +synonym: "positive regulation of integrin formation" EXACT [] +synonym: "positive regulation of integrin synthesis" EXACT [] +synonym: "stimulation of integrin biosynthetic process" NARROW [] +synonym: "up regulation of integrin biosynthetic process" EXACT [] +synonym: "up-regulation of integrin biosynthetic process" EXACT [] +synonym: "upregulation of integrin biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045113 ! regulation of integrin biosynthetic process +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0045112 ! integrin biosynthetic process + +[Term] +id: GO:0045727 +name: positive regulation of translation +namespace: biological_process +alt_id: GO:0045946 +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of protein biosynthetic process" NARROW [] +synonym: "positive regulation of protein anabolism" EXACT [] +synonym: "positive regulation of protein biosynthesis" EXACT [] +synonym: "positive regulation of protein biosynthetic process" EXACT [GOC:tb] +synonym: "positive regulation of protein formation" EXACT [] +synonym: "positive regulation of protein synthesis" EXACT [] +synonym: "stimulation of protein biosynthetic process" NARROW [] +synonym: "up regulation of protein biosynthetic process" EXACT [] +synonym: "up-regulation of protein biosynthetic process" EXACT [] +synonym: "upregulation of protein biosynthetic process" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +relationship: positively_regulates GO:0006412 ! translation + +[Term] +id: GO:0045728 +name: respiratory burst after phagocytosis +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity." [GOC:curators, ISBN:0198506732] +synonym: "metabolic burst after phagocytosis" EXACT [] +synonym: "oxidative burst after phagocytosis" EXACT [] +is_a: GO:0002679 ! respiratory burst involved in defense response + +[Term] +id: GO:0045729 +name: respiratory burst at fertilization +namespace: biological_process +def: "The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes." [ISBN:0198506732, PMID:2537493, PMID:9013127] +synonym: "metabolic burst at fertilization" EXACT [] +synonym: "oxidative burst at fertilization" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0045730 ! respiratory burst +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0045730 +name: respiratory burst +namespace: biological_process +def: "A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [ISBN:0198506732] +synonym: "metabolic burst" EXACT [] +synonym: "oxidative burst" EXACT [] +xref: Wikipedia:Respiratory_burst +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0045732 +name: positive regulation of protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] +synonym: "activation of protein catabolic process" NARROW [] +synonym: "positive regulation of protein breakdown" EXACT [] +synonym: "positive regulation of protein catabolism" EXACT [] +synonym: "positive regulation of protein degradation" EXACT [] +synonym: "stimulation of protein catabolic process" NARROW [] +synonym: "up regulation of protein catabolic process" EXACT [] +synonym: "up-regulation of protein catabolic process" EXACT [] +synonym: "upregulation of protein catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0030163 ! protein catabolic process + +[Term] +id: GO:0045733 +name: acetate catabolic process +namespace: biological_process +alt_id: GO:0019663 +def: "The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "acetate breakdown" EXACT [] +synonym: "acetate catabolism" EXACT [] +synonym: "acetate degradation" EXACT [] +synonym: "homoacetate catabolic process" RELATED [] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0045734 +name: regulation of acetate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid." [GOC:go_curators] +synonym: "regulation of acetate breakdown" EXACT [] +synonym: "regulation of acetate catabolism" EXACT [] +synonym: "regulation of acetate degradation" EXACT [] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045735 +name: nutrient reservoir activity +namespace: molecular_function +def: "Functions in the storage of nutritious substrates." [GOC:ai] +comment: Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. +subset: goslim_generic +subset: goslim_pir +synonym: "storage protein" RELATED [] +synonym: "storage protein of fat body" RELATED [] +synonym: "yolk protein" RELATED [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0045736 +name: negative regulation of cyclin-dependent protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] +is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity +is_a: GO:0045786 ! negative regulation of cell cycle +is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity +is_a: GO:1904030 ! negative regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0045737 +name: positive regulation of cyclin-dependent protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CDK activity." [GOC:go_curators, GOC:pr] +synonym: "activation of cyclin-dependent protein kinase activity" BROAD [] +synonym: "positive regulation of CDK activity" BROAD [] +synonym: "positive regulation of cyclin-dependent protein kinase activity" BROAD [GOC:pr] +synonym: "stimulation of cyclin-dependent protein kinase activity" BROAD [] +synonym: "up regulation of cyclin-dependent protein kinase activity" BROAD [] +synonym: "up-regulation of cyclin-dependent protein kinase activity" BROAD [] +synonym: "upregulation of cyclin-dependent protein kinase activity" BROAD [] +is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity +is_a: GO:0045787 ! positive regulation of cell cycle +is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity +is_a: GO:1904031 ! positive regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:0045738 +name: negative regulation of DNA repair +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair." [GOC:go_curators] +synonym: "down regulation of DNA repair" EXACT [] +synonym: "down-regulation of DNA repair" EXACT [] +synonym: "downregulation of DNA repair" EXACT [] +synonym: "inhibition of DNA repair" NARROW [] +is_a: GO:0006282 ! regulation of DNA repair +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus +relationship: negatively_regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0045739 +name: positive regulation of DNA repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA repair." [GOC:go_curators] +synonym: "activation of DNA repair" NARROW [] +synonym: "stimulation of DNA repair" NARROW [] +synonym: "up regulation of DNA repair" EXACT [] +synonym: "up-regulation of DNA repair" EXACT [] +synonym: "upregulation of DNA repair" EXACT [] +is_a: GO:0006282 ! regulation of DNA repair +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus +relationship: positively_regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0045740 +name: positive regulation of DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA replication." [GOC:go_curators] +synonym: "activation of DNA replication" NARROW [] +synonym: "stimulation of DNA replication" NARROW [] +synonym: "up regulation of DNA replication" EXACT [] +synonym: "up-regulation of DNA replication" EXACT [] +synonym: "upregulation of DNA replication" EXACT [] +is_a: GO:0006275 ! regulation of DNA replication +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +relationship: positively_regulates GO:0006260 ! DNA replication + +[Term] +id: GO:0045741 +name: positive regulation of epidermal growth factor-activated receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] +synonym: "activation of epidermal growth factor receptor activity" NARROW [] +synonym: "positive regulation of EGF receptor activity" EXACT [] +synonym: "positive regulation of EGFR activity" EXACT [] +synonym: "positive regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "stimulation of epidermal growth factor receptor activity" NARROW [] +synonym: "up regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "up-regulation of epidermal growth factor receptor activity" EXACT [] +synonym: "upregulation of epidermal growth factor receptor activity" EXACT [] +is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity +is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0045742 +name: positive regulation of epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of EGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of EGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of EGFR signaling pathway" EXACT [] +synonym: "stimulation of epidermal growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of epidermal growth factor receptor signaling pathway" EXACT [] +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +is_a: GO:1901186 ! positive regulation of ERBB signaling pathway +relationship: positively_regulates GO:0007173 ! epidermal growth factor receptor signaling pathway + +[Term] +id: GO:0045743 +name: positive regulation of fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of FGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of FGF receptor signalling pathway" EXACT [] +synonym: "positive regulation of FGFR signaling pathway" EXACT [] +synonym: "stimulation of fibroblast growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of fibroblast growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of fibroblast growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +relationship: positively_regulates GO:0008543 ! fibroblast growth factor receptor signaling pathway + +[Term] +id: GO:0045744 +name: negative regulation of G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] +synonym: "down regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "down-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "downregulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "inhibition of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "negative regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "negative regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "negative regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "negative regulation of GPCR protein signaling pathway" EXACT [] +synonym: "negative regulation of GPCR protein signalling pathway" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0045745 +name: positive regulation of G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity." [GOC:go_curators] +synonym: "activation of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "positive regulation of G protein coupled receptor protein signaling pathway" EXACT [] +synonym: "positive regulation of G protein coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "positive regulation of G-protein coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] +synonym: "positive regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] +synonym: "positive regulation of GPCR protein signaling pathway" EXACT [] +synonym: "positive regulation of GPCR protein signalling pathway" EXACT [] +synonym: "stimulation of G-protein coupled receptor protein signaling pathway" NARROW [] +synonym: "up regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "up-regulation of G-protein coupled receptor protein signaling pathway" EXACT [] +synonym: "upregulation of G-protein coupled receptor protein signaling pathway" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0045746 +name: negative regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "down regulation of Notch signaling pathway" EXACT [] +synonym: "down-regulation of Notch signaling pathway" EXACT [] +synonym: "downregulation of Notch signaling pathway" EXACT [] +synonym: "inhibition of Notch signaling pathway" NARROW [] +synonym: "negative regulation of N signaling pathway" EXACT [] +synonym: "negative regulation of N signalling pathway" EXACT [] +synonym: "negative regulation of Notch signalling pathway" EXACT [] +is_a: GO:0008593 ! regulation of Notch signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0045747 +name: positive regulation of Notch signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] +synonym: "activation of Notch signaling pathway" NARROW [] +synonym: "positive regulation of N signaling pathway" EXACT [] +synonym: "positive regulation of N signalling pathway" EXACT [] +synonym: "positive regulation of Notch signalling pathway" EXACT [] +synonym: "stimulation of Notch signaling pathway" NARROW [] +synonym: "up regulation of Notch signaling pathway" EXACT [] +synonym: "up-regulation of Notch signaling pathway" EXACT [] +synonym: "upregulation of Notch signaling pathway" EXACT [] +is_a: GO:0008593 ! regulation of Notch signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007219 ! Notch signaling pathway + +[Term] +id: GO:0045748 +name: positive regulation of R8 cell spacing in compound eye +namespace: biological_process +def: "Any process that activates or enforces the correct R8 cell spacing in a compound eye." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of R8 spacing" NARROW [] +synonym: "positive regulation of R8 spacing" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of R8 spacing" NARROW [] +synonym: "up regulation of R8 spacing" EXACT [] +synonym: "up-regulation of R8 spacing" EXACT [] +synonym: "upregulation of R8 spacing" EXACT [] +is_a: GO:0045468 ! regulation of R8 cell spacing in compound eye + +[Term] +id: GO:0045749 +name: obsolete negative regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "down regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "down-regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "downregulation of S phase of mitotic cell cycle" EXACT [] +synonym: "inhibition of S phase of mitotic cell cycle" NARROW [] +synonym: "negative regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "negative regulation of S-phase of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045750 +name: obsolete positive regulation of S phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity." [GOC:go_curators] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "activation of S phase of mitotic cell cycle" NARROW [] +synonym: "positive regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "positive regulation of S-phase of mitotic cell cycle" EXACT [] +synonym: "stimulation of S phase of mitotic cell cycle" NARROW [] +synonym: "up regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "up-regulation of S phase of mitotic cell cycle" EXACT [] +synonym: "upregulation of S phase of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045751 +name: negative regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "down regulation of Toll signaling pathway" EXACT [] +synonym: "down-regulation of Toll signaling pathway" EXACT [] +synonym: "downregulation of Toll signaling pathway" EXACT [] +synonym: "inhibition of Toll signaling pathway" NARROW [] +synonym: "negative regulation of Tl signaling pathway" EXACT [] +synonym: "negative regulation of Tl signalling pathway" EXACT [] +is_a: GO:0008592 ! regulation of Toll signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0045752 +name: positive regulation of Toll signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] +synonym: "activation of Toll signaling pathway" NARROW [] +synonym: "positive regulation of Tl signaling pathway" EXACT [] +synonym: "positive regulation of Tl signalling pathway" EXACT [] +synonym: "stimulation of Toll signaling pathway" NARROW [] +synonym: "up regulation of Toll signaling pathway" EXACT [] +synonym: "up-regulation of Toll signaling pathway" EXACT [] +synonym: "upregulation of Toll signaling pathway" EXACT [] +is_a: GO:0008592 ! regulation of Toll signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0008063 ! Toll signaling pathway + +[Term] +id: GO:0045753 +name: negative regulation of acetate catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "down regulation of acetate catabolic process" EXACT [] +synonym: "down-regulation of acetate catabolic process" EXACT [] +synonym: "downregulation of acetate catabolic process" EXACT [] +synonym: "inhibition of acetate catabolic process" NARROW [] +synonym: "negative regulation of acetate breakdown" EXACT [] +synonym: "negative regulation of acetate catabolism" EXACT [] +synonym: "negative regulation of acetate degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045754 +name: positive regulation of acetate catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "activation of acetate catabolic process" NARROW [] +synonym: "positive regulation of acetate breakdown" EXACT [] +synonym: "positive regulation of acetate catabolism" EXACT [] +synonym: "positive regulation of acetate degradation" EXACT [] +synonym: "stimulation of acetate catabolic process" NARROW [] +synonym: "up regulation of acetate catabolic process" EXACT [] +synonym: "up-regulation of acetate catabolic process" EXACT [] +synonym: "upregulation of acetate catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045734 ! regulation of acetate catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0045733 ! acetate catabolic process + +[Term] +id: GO:0045755 +name: negative regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "down regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "down-regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "downregulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "inhibition of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "negative regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "negative regulation of initiation of acetate degradation by acetate" EXACT [] +is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate +is_a: GO:1901458 ! negative regulation of response to acetate +relationship: negatively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045756 +name: positive regulation of initiation of acetate catabolic process by acetate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators] +synonym: "activation of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "positive regulation of initiation of acetate breakdown by acetate" EXACT [] +synonym: "positive regulation of initiation of acetate degradation by acetate" EXACT [] +synonym: "stimulation of initiation of acetate catabolic process by acetate" NARROW [] +synonym: "up regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "up-regulation of initiation of acetate catabolic process by acetate" EXACT [] +synonym: "upregulation of initiation of acetate catabolic process by acetate" EXACT [] +is_a: GO:0045147 ! regulation of initiation of acetate catabolic process by acetate +is_a: GO:0045754 ! positive regulation of acetate catabolic process +is_a: GO:1901459 ! positive regulation of response to acetate +relationship: positively_regulates GO:0045146 ! initiation of acetate catabolic process by acetate + +[Term] +id: GO:0045757 +name: obsolete negative regulation of actin polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +synonym: "negative regulation of actin polymerization and/or depolymerization" EXACT [] +is_obsolete: true +consider: GO:0030835 +consider: GO:0030837 + +[Term] +id: GO:0045758 +name: obsolete positive regulation of actin polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of actin polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +synonym: "positive regulation of actin polymerization and/or depolymerization" EXACT [] +is_obsolete: true +consider: GO:0030836 +consider: GO:0030838 + +[Term] +id: GO:0045759 +name: negative regulation of action potential +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] +synonym: "down regulation of action potential" EXACT [] +synonym: "down-regulation of action potential" EXACT [] +synonym: "downregulation of action potential" EXACT [] +synonym: "inhibition of action potential" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0098900 ! regulation of action potential +relationship: negatively_regulates GO:0001508 ! action potential + +[Term] +id: GO:0045760 +name: positive regulation of action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:go_curators] +synonym: "activation of action potential" NARROW [] +synonym: "stimulation of action potential" NARROW [] +synonym: "up regulation of action potential" EXACT [] +synonym: "up-regulation of action potential" EXACT [] +synonym: "upregulation of action potential" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0098900 ! regulation of action potential +relationship: positively_regulates GO:0001508 ! action potential + +[Term] +id: GO:0045761 +name: regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase regulator" RELATED [] +synonym: "regulation of adenylyl cyclase activity" EXACT [] +is_a: GO:0031279 ! regulation of cyclase activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0045762 +name: positive regulation of adenylate cyclase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] +synonym: "adenylate cyclase activator" RELATED [] +synonym: "positive regulation of adenylyl cyclase activity" EXACT [] +synonym: "stimulation of adenylate cyclase activity" NARROW [] +synonym: "up regulation of adenylate cyclase activity" EXACT [] +synonym: "up-regulation of adenylate cyclase activity" EXACT [] +synonym: "upregulation of adenylate cyclase activity" EXACT [] +is_a: GO:0031281 ! positive regulation of cyclase activity +is_a: GO:0045761 ! regulation of adenylate cyclase activity +is_a: GO:0051349 ! positive regulation of lyase activity + +[Term] +id: GO:0045763 +name: negative regulation of cellular amino acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] +synonym: "down regulation of amino acid metabolic process" EXACT [] +synonym: "down-regulation of amino acid metabolic process" EXACT [] +synonym: "downregulation of amino acid metabolic process" EXACT [] +synonym: "inhibition of amino acid metabolic process" NARROW [] +synonym: "negative regulation of amino acid metabolism" EXACT [] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0045764 +name: positive regulation of cellular amino acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid." [GOC:go_curators] +synonym: "activation of amino acid metabolic process" NARROW [] +synonym: "positive regulation of amino acid metabolism" EXACT [] +synonym: "stimulation of amino acid metabolic process" NARROW [] +synonym: "up regulation of amino acid metabolic process" EXACT [] +synonym: "up-regulation of amino acid metabolic process" EXACT [] +synonym: "upregulation of amino acid metabolic process" EXACT [] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:0045765 +name: regulation of angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of angiogenesis." [GOC:go_curators] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:1901342 ! regulation of vasculature development +relationship: regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0045766 +name: positive regulation of angiogenesis +namespace: biological_process +def: "Any process that activates or increases angiogenesis." [GOC:go_curators] +synonym: "activation of angiogenesis" NARROW [] +synonym: "stimulation of angiogenesis" NARROW [] +synonym: "up regulation of angiogenesis" EXACT [] +synonym: "up-regulation of angiogenesis" EXACT [] +synonym: "upregulation of angiogenesis" EXACT [] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:1904018 ! positive regulation of vasculature development +relationship: positively_regulates GO:0001525 ! angiogenesis + +[Term] +id: GO:0045767 +name: obsolete regulation of anti-apoptosis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] +comment: This term was made obsolete because it was ill-defined. +synonym: "regulation of anti-apoptosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045768 +name: obsolete positive regulation of anti-apoptosis +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] +comment: This term was made obsolete because it was ill-defined. +synonym: "activation of anti-apoptosis" NARROW [] +synonym: "positive regulation of anti-apoptosis" EXACT [] +synonym: "stimulation of anti-apoptosis" NARROW [] +synonym: "up regulation of anti-apoptosis" EXACT [] +synonym: "up-regulation of anti-apoptosis" EXACT [] +synonym: "upregulation of anti-apoptosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045769 +name: negative regulation of asymmetric cell division +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] +synonym: "down regulation of asymmetric cell division" EXACT [] +synonym: "down-regulation of asymmetric cell division" EXACT [] +synonym: "downregulation of asymmetric cell division" EXACT [] +synonym: "inhibition of asymmetric cell division" NARROW [] +is_a: GO:0009786 ! regulation of asymmetric cell division +is_a: GO:0051782 ! negative regulation of cell division +relationship: negatively_regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0045770 +name: positive regulation of asymmetric cell division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asymmetric cell division." [GOC:go_curators] +synonym: "activation of asymmetric cell division" NARROW [] +synonym: "stimulation of asymmetric cell division" NARROW [] +synonym: "up regulation of asymmetric cell division" EXACT [] +synonym: "up-regulation of asymmetric cell division" EXACT [] +synonym: "upregulation of asymmetric cell division" EXACT [] +is_a: GO:0009786 ! regulation of asymmetric cell division +is_a: GO:0051781 ! positive regulation of cell division +relationship: positively_regulates GO:0008356 ! asymmetric cell division + +[Term] +id: GO:0045771 +name: negative regulation of autophagosome size +namespace: biological_process +def: "Any process that reduces autophagosome size." [GOC:autophagy, GOC:go_curators] +synonym: "down regulation of autophagic vacuole size" EXACT [] +synonym: "down-regulation of autophagic vacuole size" EXACT [] +synonym: "downregulation of autophagic vacuole size" EXACT [] +synonym: "inhibition of autophagic vacuole size" NARROW [] +synonym: "negative regulation of autophagic vacuole size" EXACT [GOC:autophagy] +is_a: GO:0016243 ! regulation of autophagosome size + +[Term] +id: GO:0045772 +name: positive regulation of autophagosome size +namespace: biological_process +def: "Any process that increases autophagosome size." [GOC:autophagy, GOC:go_curators] +synonym: "activation of autophagic vacuole size" NARROW [] +synonym: "positive regulation of autophagic vacuole size" EXACT [GOC:autophagy] +synonym: "stimulation of autophagic vacuole size" NARROW [] +synonym: "up regulation of autophagic vacuole size" EXACT [] +synonym: "up-regulation of autophagic vacuole size" EXACT [] +synonym: "upregulation of autophagic vacuole size" EXACT [] +is_a: GO:0016243 ! regulation of autophagosome size + +[Term] +id: GO:0045773 +name: positive regulation of axon extension +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axon extension." [GOC:go_curators] +synonym: "activation of axon extension" NARROW [] +synonym: "stimulation of axon extension" NARROW [] +synonym: "up regulation of axon extension" EXACT [] +synonym: "up-regulation of axon extension" EXACT [] +synonym: "upregulation of axon extension" EXACT [] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0050772 ! positive regulation of axonogenesis +relationship: positively_regulates GO:0048675 ! axon extension + +[Term] +id: GO:0045774 +name: negative regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "down regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "down-regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "downregulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "inhibition of beta 2 integrin biosynthetic process" NARROW [] +synonym: "negative regulation of beta 2 integrin anabolism" EXACT [] +synonym: "negative regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "negative regulation of beta 2 integrin formation" EXACT [] +synonym: "negative regulation of beta 2 integrin synthesis" EXACT [] +is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process +is_a: GO:0045720 ! negative regulation of integrin biosynthetic process +relationship: negatively_regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045775 +name: positive regulation of beta 2 integrin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators] +synonym: "activation of beta 2 integrin biosynthetic process" NARROW [] +synonym: "positive regulation of beta 2 integrin anabolism" EXACT [] +synonym: "positive regulation of beta 2 integrin biosynthesis" EXACT [] +synonym: "positive regulation of beta 2 integrin formation" EXACT [] +synonym: "positive regulation of beta 2 integrin synthesis" EXACT [] +synonym: "stimulation of beta 2 integrin biosynthetic process" NARROW [] +synonym: "up regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "up-regulation of beta 2 integrin biosynthetic process" EXACT [] +synonym: "upregulation of beta 2 integrin biosynthetic process" EXACT [] +is_a: GO:0045115 ! regulation of beta 2 integrin biosynthetic process +is_a: GO:0045726 ! positive regulation of integrin biosynthetic process +relationship: positively_regulates GO:0045114 ! beta 2 integrin biosynthetic process + +[Term] +id: GO:0045776 +name: negative regulation of blood pressure +namespace: biological_process +def: "Any process in which the force of blood traveling through the circulatory system is decreased." [GOC:go_curators, GOC:mtg_cardio] +synonym: "down regulation of blood pressure" EXACT [] +synonym: "down-regulation of blood pressure" EXACT [] +synonym: "downregulation of blood pressure" EXACT [] +synonym: "inhibition of blood pressure" NARROW [] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0045777 +name: positive regulation of blood pressure +namespace: biological_process +def: "Any process in which the force of blood traveling through the circulatory system is increased." [GOC:go_curators, GOC:mtg_cardio] +synonym: "activation of blood pressure" NARROW [] +synonym: "stimulation of blood pressure" NARROW [] +synonym: "up regulation of blood pressure" EXACT [] +synonym: "up-regulation of blood pressure" EXACT [] +synonym: "upregulation of blood pressure" EXACT [] +is_a: GO:0008217 ! regulation of blood pressure + +[Term] +id: GO:0045778 +name: positive regulation of ossification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] +synonym: "activation of ossification" NARROW [] +synonym: "positive regulation of bone biosynthesis" EXACT [] +synonym: "positive regulation of bone formation" EXACT [] +synonym: "stimulation of ossification" NARROW [] +synonym: "up regulation of ossification" EXACT [] +synonym: "up-regulation of ossification" EXACT [] +synonym: "upregulation of ossification" EXACT [] +is_a: GO:0030278 ! regulation of ossification +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0001503 ! ossification + +[Term] +id: GO:0045779 +name: negative regulation of bone resorption +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption." [GOC:go_curators] +synonym: "down regulation of bone resorption" EXACT [] +synonym: "down-regulation of bone resorption" EXACT [] +synonym: "downregulation of bone resorption" EXACT [] +synonym: "inhibition of bone resorption" NARROW [] +is_a: GO:0045124 ! regulation of bone resorption +is_a: GO:0046851 ! negative regulation of bone remodeling +relationship: negatively_regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045780 +name: positive regulation of bone resorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone resorption." [GOC:go_curators] +synonym: "activation of bone resorption" NARROW [] +synonym: "stimulation of bone resorption" NARROW [] +synonym: "up regulation of bone resorption" EXACT [] +synonym: "up-regulation of bone resorption" EXACT [] +synonym: "upregulation of bone resorption" EXACT [] +is_a: GO:0045124 ! regulation of bone resorption +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0045453 ! bone resorption + +[Term] +id: GO:0045781 +name: negative regulation of cell budding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell budding." [GOC:go_curators] +synonym: "down regulation of cell budding" EXACT [] +synonym: "down-regulation of cell budding" EXACT [] +synonym: "downregulation of cell budding" EXACT [] +synonym: "inhibition of cell budding" NARROW [] +synonym: "negative regulation of budding" BROAD [] +is_a: GO:0007116 ! regulation of cell budding +is_a: GO:0051782 ! negative regulation of cell division +is_a: GO:1903665 ! negative regulation of asexual reproduction +relationship: negatively_regulates GO:0007114 ! cell budding + +[Term] +id: GO:0045782 +name: positive regulation of cell budding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell budding." [GOC:go_curators] +synonym: "activation of cell budding" NARROW [] +synonym: "positive regulation of budding" BROAD [] +synonym: "stimulation of cell budding" NARROW [] +synonym: "up regulation of cell budding" EXACT [] +synonym: "up-regulation of cell budding" EXACT [] +synonym: "upregulation of cell budding" EXACT [] +is_a: GO:0007116 ! regulation of cell budding +is_a: GO:0051781 ! positive regulation of cell division +is_a: GO:1903666 ! positive regulation of asexual reproduction +relationship: positively_regulates GO:0007114 ! cell budding + +[Term] +id: GO:0045783 +name: obsolete negative regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that reduces the concentration of calcium in the ER." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +synonym: "negative regulation of calcium in ER" EXACT [] +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0045784 +name: obsolete positive regulation of calcium in ER +namespace: biological_process +def: "OBSOLETE. Any process that increases the concentration of calcium in the ER." [GOC:go_curators] +comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). +synonym: "positive regulation of calcium in ER" EXACT [] +is_obsolete: true +consider: GO:0005783 +consider: GO:0006874 + +[Term] +id: GO:0045785 +name: positive regulation of cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell adhesion." [GOC:go_curators] +synonym: "activation of cell adhesion" NARROW [] +synonym: "stimulation of cell adhesion" NARROW [] +synonym: "up regulation of cell adhesion" EXACT [] +synonym: "up-regulation of cell adhesion" EXACT [] +synonym: "upregulation of cell adhesion" EXACT [] +is_a: GO:0030155 ! regulation of cell adhesion +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0007155 ! cell adhesion + +[Term] +id: GO:0045786 +name: negative regulation of cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through cell cycle" EXACT [] +synonym: "down-regulation of progression through cell cycle" EXACT [] +synonym: "downregulation of progression through cell cycle" EXACT [] +synonym: "inhibition of progression through cell cycle" NARROW [] +synonym: "negative regulation of cell cycle progression" EXACT [] +synonym: "negative regulation of progression through cell cycle" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051726 ! regulation of cell cycle +relationship: negatively_regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0045787 +name: positive regulation of cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] +synonym: "activation of progression through cell cycle" NARROW [] +synonym: "positive regulation of cell cycle progression" EXACT [] +synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through cell cycle" NARROW [] +synonym: "up regulation of progression through cell cycle" EXACT [] +synonym: "up-regulation of progression through cell cycle" EXACT [] +synonym: "upregulation of progression through cell cycle" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051726 ! regulation of cell cycle +relationship: positively_regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0045792 +name: negative regulation of cell size +namespace: biological_process +def: "Any process that reduces cell size." [GOC:go_curators] +synonym: "down regulation of cell size" EXACT [] +synonym: "down-regulation of cell size" EXACT [] +synonym: "downregulation of cell size" EXACT [] +synonym: "inhibition of cell size" NARROW [] +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0045793 +name: positive regulation of cell size +namespace: biological_process +def: "Any process that increases cell size." [GOC:go_curators] +synonym: "activation of cell size" NARROW [] +synonym: "stimulation of cell size" NARROW [] +synonym: "up regulation of cell size" EXACT [] +synonym: "up-regulation of cell size" EXACT [] +synonym: "upregulation of cell size" EXACT [] +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0045794 +name: negative regulation of cell volume +namespace: biological_process +def: "Any process that decreases cell volume." [GOC:go_curators] +synonym: "cell regulatory volume decrease" RELATED [PMID:12388065] +synonym: "RVD" RELATED [PMID:12388065] +is_a: GO:0006884 ! cell volume homeostasis + +[Term] +id: GO:0045795 +name: positive regulation of cell volume +namespace: biological_process +def: "Any process that increases cell volume." [GOC:go_curators] +is_a: GO:0006884 ! cell volume homeostasis + +[Term] +id: GO:0045796 +name: negative regulation of intestinal cholesterol absorption +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] +synonym: "down regulation of cholesterol absorption" EXACT [] +synonym: "down-regulation of cholesterol absorption" EXACT [] +synonym: "downregulation of cholesterol absorption" EXACT [] +synonym: "inhibition of cholesterol absorption" NARROW [] +is_a: GO:0030300 ! regulation of intestinal cholesterol absorption +is_a: GO:0032375 ! negative regulation of cholesterol transport +is_a: GO:1904730 ! negative regulation of intestinal lipid absorption +relationship: negatively_regulates GO:0030299 ! intestinal cholesterol absorption + +[Term] +id: GO:0045797 +name: positive regulation of intestinal cholesterol absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine." [GOC:go_curators] +synonym: "activation of cholesterol absorption" NARROW [] +synonym: "stimulation of cholesterol absorption" NARROW [] +synonym: "up regulation of cholesterol absorption" EXACT [] +synonym: "up-regulation of cholesterol absorption" EXACT [] +synonym: "upregulation of cholesterol absorption" EXACT [] +is_a: GO:0030300 ! regulation of intestinal cholesterol absorption +is_a: GO:0032376 ! positive regulation of cholesterol transport +is_a: GO:1904731 ! positive regulation of intestinal lipid absorption +relationship: positively_regulates GO:0030299 ! intestinal cholesterol absorption + +[Term] +id: GO:0045798 +name: negative regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "down regulation of chromatin assembly or disassembly" EXACT [] +synonym: "down-regulation of chromatin assembly or disassembly" EXACT [] +synonym: "downregulation of chromatin assembly or disassembly" EXACT [] +synonym: "inhibition of chromatin assembly or disassembly" NARROW [] +synonym: "negative regulation of chromatin assembly/disassembly" EXACT [] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +is_a: GO:1905268 ! negative regulation of chromatin organization +relationship: negatively_regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0045799 +name: positive regulation of chromatin assembly or disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] +synonym: "activation of chromatin assembly or disassembly" NARROW [] +synonym: "positive regulation of chromatin assembly/disassembly" EXACT [] +synonym: "stimulation of chromatin assembly or disassembly" NARROW [] +synonym: "up regulation of chromatin assembly or disassembly" EXACT [] +synonym: "up-regulation of chromatin assembly or disassembly" EXACT [] +synonym: "upregulation of chromatin assembly or disassembly" EXACT [] +is_a: GO:0001672 ! regulation of chromatin assembly or disassembly +is_a: GO:1905269 ! positive regulation of chromatin organization +relationship: positively_regulates GO:0006333 ! chromatin assembly or disassembly + +[Term] +id: GO:0045800 +name: negative regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] +synonym: "down regulation of cuticle tanning" EXACT [] +synonym: "down-regulation of cuticle tanning" EXACT [] +synonym: "downregulation of cuticle tanning" EXACT [] +synonym: "inhibition of cuticle tanning" NARROW [] +synonym: "negative regulation of cuticle hardening" NARROW [] +synonym: "negative regulation of cuticle tanning" EXACT [] +is_a: GO:0007564 ! regulation of chitin-based cuticle tanning +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007593 ! chitin-based cuticle sclerotization + +[Term] +id: GO:0045801 +name: positive regulation of chitin-based cuticle tanning +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] +synonym: "activation of cuticle tanning" NARROW [] +synonym: "positive regulation of cuticle hardening" NARROW [] +synonym: "positive regulation of cuticle tanning" EXACT [] +synonym: "stimulation of cuticle tanning" NARROW [] +synonym: "up regulation of cuticle tanning" EXACT [] +synonym: "up-regulation of cuticle tanning" EXACT [] +synonym: "upregulation of cuticle tanning" EXACT [] +is_a: GO:0007564 ! regulation of chitin-based cuticle tanning +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007593 ! chitin-based cuticle sclerotization + +[Term] +id: GO:0045802 +name: obsolete negative regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. +synonym: "negative regulation of cytoskeleton" EXACT [] +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0045803 +name: obsolete positive regulation of cytoskeleton +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] +comment: This term was made obsolete because cytoskeleton is not a process, so the term made no sense. +synonym: "positive regulation of cytoskeleton" EXACT [] +is_obsolete: true +consider: GO:0007010 + +[Term] +id: GO:0045804 +name: negative regulation of eclosion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion." [GOC:go_curators] +synonym: "down regulation of eclosion" EXACT [] +synonym: "down-regulation of eclosion" EXACT [] +synonym: "downregulation of eclosion" EXACT [] +synonym: "inhibition of eclosion" NARROW [] +is_a: GO:0007563 ! regulation of eclosion +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007562 ! eclosion + +[Term] +id: GO:0045805 +name: positive regulation of eclosion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eclosion." [GOC:go_curators] +synonym: "activation of eclosion" NARROW [] +synonym: "stimulation of eclosion" NARROW [] +synonym: "up regulation of eclosion" EXACT [] +synonym: "up-regulation of eclosion" EXACT [] +synonym: "upregulation of eclosion" EXACT [] +is_a: GO:0007563 ! regulation of eclosion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007562 ! eclosion + +[Term] +id: GO:0045806 +name: negative regulation of endocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis." [GOC:go_curators] +synonym: "down regulation of endocytosis" EXACT [] +synonym: "down-regulation of endocytosis" EXACT [] +synonym: "downregulation of endocytosis" EXACT [] +synonym: "inhibition of endocytosis" NARROW [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0045807 +name: positive regulation of endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocytosis." [GOC:go_curators] +synonym: "activation of endocytosis" NARROW [] +synonym: "stimulation of endocytosis" NARROW [] +synonym: "up regulation of endocytosis" EXACT [] +synonym: "up-regulation of endocytosis" EXACT [] +synonym: "upregulation of endocytosis" EXACT [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051130 ! positive regulation of cellular component organization +relationship: positively_regulates GO:0006897 ! endocytosis + +[Term] +id: GO:0045808 +name: negative regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] +synonym: "down regulation of establishment of competence for transformation" EXACT [] +synonym: "down-regulation of establishment of competence for transformation" EXACT [] +synonym: "downregulation of establishment of competence for transformation" EXACT [] +synonym: "inhibition of establishment of competence for transformation" NARROW [] +synonym: "inhibitor of the establishment of competence for transformation activity" RELATED [] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032105 ! negative regulation of response to extracellular stimulus +is_a: GO:0045304 ! regulation of establishment of competence for transformation +relationship: negatively_regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045809 +name: positive regulation of establishment of competence for transformation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of competence for transformation." [GOC:go_curators] +synonym: "activation of establishment of competence for transformation" NARROW [] +synonym: "activator of the establishment of competence for transformation activity" RELATED [] +synonym: "stimulation of establishment of competence for transformation" NARROW [] +synonym: "up regulation of establishment of competence for transformation" EXACT [] +synonym: "up-regulation of establishment of competence for transformation" EXACT [] +synonym: "upregulation of establishment of competence for transformation" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032106 ! positive regulation of response to extracellular stimulus +is_a: GO:0045304 ! regulation of establishment of competence for transformation +relationship: positively_regulates GO:0030420 ! establishment of competence for transformation + +[Term] +id: GO:0045812 +name: negative regulation of Wnt signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "down-regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "downregulation of frizzled-2 signaling pathway" EXACT [] +synonym: "inhibition of frizzled-2 signaling pathway" NARROW [] +synonym: "negative regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "negative regulation of frizzled-2 signalling pathway" EXACT [] +synonym: "negative regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] +synonym: "negative regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] +is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +relationship: negatively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway + +[Term] +id: GO:0045813 +name: positive regulation of Wnt signaling pathway, calcium modulating pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:go_curators] +synonym: "activation of frizzled-2 signaling pathway" NARROW [] +synonym: "positive regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "positive regulation of frizzled-2 signalling pathway" EXACT [] +synonym: "positive regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] +synonym: "positive regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] +synonym: "stimulation of frizzled-2 signaling pathway" NARROW [] +synonym: "up regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "up-regulation of frizzled-2 signaling pathway" EXACT [] +synonym: "upregulation of frizzled-2 signaling pathway" EXACT [] +is_a: GO:0008591 ! regulation of Wnt signaling pathway, calcium modulating pathway +is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway +relationship: positively_regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway + +[Term] +id: GO:0045814 +name: negative regulation of gene expression, epigenetic +namespace: biological_process +def: "An epigenetic process that stops, prevents or reduces the rate of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:22243696] +synonym: "down regulation of gene expression, epigenetic" EXACT [] +synonym: "down-regulation of gene expression, epigenetic" EXACT [] +synonym: "downregulation of gene expression, epigenetic" EXACT [] +synonym: "gene silencing" RELATED [] +synonym: "inhibition of gene expression, epigenetic" NARROW [] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0045815 +name: epigenetic maintenance of chromatin in transcription-competent conformation +namespace: biological_process +alt_id: GO:0048096 +def: "An epigenetic process that capacitates gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA." [PMID:34414474] +comment: This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. Do not confuse with GO:0140673 ; co-transcriptional chromatin reassembly, which describes the reforming of chromatin after RNA polymerase II passage. +synonym: "activation of gene expression, epigenetic" RELATED [] +synonym: "chromatin-mediated maintenance of transcription" EXACT [] +synonym: "euchromatin assembly" RELATED [] +synonym: "euchromatin organisation" RELATED [] +synonym: "euchromatin organization" RELATED [] +synonym: "long-term maintenance of gene activation" RELATED [] +synonym: "maintenance of chromatin in transcription-competent conformation" EXACT [] +synonym: "positive regulation of gene expression, epigenetic" EXACT [] +synonym: "stimulation of gene expression, epigenetic" RELATED [] +synonym: "up regulation of gene expression, epigenetic" EXACT [] +synonym: "up-regulation of gene expression, epigenetic" EXACT [] +synonym: "upregulation of gene expression, epigenetic" EXACT [] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0045818 +name: negative regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +synonym: "down regulation of glycogen catabolic process" EXACT [] +synonym: "down-regulation of glycogen catabolic process" EXACT [] +synonym: "downregulation of glycogen catabolic process" EXACT [] +synonym: "inhibition of glycogen catabolic process" NARROW [] +synonym: "negative regulation of glycogen breakdown" EXACT [] +synonym: "negative regulation of glycogen catabolism" EXACT [] +synonym: "negative regulation of glycogen degradation" EXACT [] +synonym: "negative regulation of glycogenolysis" EXACT [GOC:sl] +is_a: GO:0005981 ! regulation of glycogen catabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0070874 ! negative regulation of glycogen metabolic process +relationship: negatively_regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0045819 +name: positive regulation of glycogen catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] +synonym: "activation of glycogen catabolic process" NARROW [] +synonym: "positive regulation of glycogen breakdown" EXACT [] +synonym: "positive regulation of glycogen catabolism" EXACT [] +synonym: "positive regulation of glycogen degradation" EXACT [] +synonym: "positive regulation of glycogenolysis" EXACT [GOC:sl] +synonym: "stimulation of glycogen catabolic process" NARROW [] +synonym: "up regulation of glycogen catabolic process" EXACT [] +synonym: "up-regulation of glycogen catabolic process" EXACT [] +synonym: "upregulation of glycogen catabolic process" EXACT [] +is_a: GO:0005981 ! regulation of glycogen catabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0070875 ! positive regulation of glycogen metabolic process +relationship: positively_regulates GO:0005980 ! glycogen catabolic process + +[Term] +id: GO:0045820 +name: negative regulation of glycolytic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis." [GOC:go_curators] +synonym: "down regulation of glycolysis" EXACT [] +synonym: "down-regulation of glycolysis" EXACT [] +synonym: "downregulation of glycolysis" EXACT [] +synonym: "inhibition of glycolysis" NARROW [] +is_a: GO:0006110 ! regulation of glycolytic process +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0042326 ! negative regulation of phosphorylation +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +is_a: GO:1903579 ! negative regulation of ATP metabolic process +relationship: negatively_regulates GO:0006096 ! glycolytic process + +[Term] +id: GO:0045821 +name: positive regulation of glycolytic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycolysis." [GOC:go_curators] +synonym: "activation of glycolysis" NARROW [] +synonym: "stimulation of glycolysis" NARROW [] +synonym: "up regulation of glycolysis" EXACT [] +synonym: "up-regulation of glycolysis" EXACT [] +synonym: "upregulation of glycolysis" EXACT [] +is_a: GO:0006110 ! regulation of glycolytic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0042327 ! positive regulation of phosphorylation +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +is_a: GO:1903580 ! positive regulation of ATP metabolic process +relationship: positively_regulates GO:0006096 ! glycolytic process + +[Term] +id: GO:0045822 +name: negative regulation of heart contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction." [GOC:go_curators] +synonym: "down regulation of heart contraction" EXACT [] +synonym: "down-regulation of heart contraction" EXACT [] +synonym: "downregulation of heart contraction" EXACT [] +synonym: "inhibition of heart contraction" NARROW [] +synonym: "negative regulation of cardiac contraction" RELATED [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:1903523 ! negative regulation of blood circulation +relationship: negatively_regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0045823 +name: positive regulation of heart contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heart contraction." [GOC:go_curators] +synonym: "activation of heart contraction" NARROW [] +synonym: "positive regulation of cardiac contraction" EXACT [] +synonym: "stimulation of heart contraction" NARROW [] +synonym: "up regulation of heart contraction" EXACT [] +synonym: "up-regulation of heart contraction" EXACT [] +synonym: "upregulation of heart contraction" EXACT [] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:1903524 ! positive regulation of blood circulation +relationship: positively_regulates GO:0060047 ! heart contraction + +[Term] +id: GO:0045824 +name: negative regulation of innate immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response." [GOC:go_curators] +synonym: "down regulation of innate immune response" EXACT [] +synonym: "down-regulation of innate immune response" EXACT [] +synonym: "downregulation of innate immune response" EXACT [] +synonym: "inhibition of innate immune response" NARROW [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050777 ! negative regulation of immune response +relationship: negatively_regulates GO:0045087 ! innate immune response + +[Term] +id: GO:0045825 +name: obsolete negative regulation of intermediate filament polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" EXACT [] +is_obsolete: true +consider: GO:0030840 +consider: GO:0030843 + +[Term] +id: GO:0045826 +name: obsolete positive regulation of intermediate filament polymerization and/or depolymerization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization and/or depolymerization." [GOC:go_curators] +comment: This term was made obsolete because it has been split. +synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" EXACT [] +is_obsolete: true +consider: GO:0030841 +consider: GO:0030844 + +[Term] +id: GO:0045827 +name: negative regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] +synonym: "down regulation of isoprenoid metabolic process" EXACT [] +synonym: "down-regulation of isoprenoid metabolic process" EXACT [] +synonym: "downregulation of isoprenoid metabolic process" EXACT [] +synonym: "inhibition of isoprenoid metabolic process" NARROW [] +synonym: "negative regulation of isoprenoid metabolism" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +relationship: negatively_regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0045828 +name: positive regulation of isoprenoid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid." [GOC:go_curators] +synonym: "activation of isoprenoid metabolic process" NARROW [] +synonym: "positive regulation of isoprenoid metabolism" EXACT [] +synonym: "stimulation of isoprenoid metabolic process" NARROW [] +synonym: "up regulation of isoprenoid metabolic process" EXACT [] +synonym: "up-regulation of isoprenoid metabolic process" EXACT [] +synonym: "upregulation of isoprenoid metabolic process" EXACT [] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +relationship: positively_regulates GO:0006720 ! isoprenoid metabolic process + +[Term] +id: GO:0045829 +name: negative regulation of isotype switching +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching." [GOC:go_curators] +synonym: "down regulation of isotype switching" EXACT [] +synonym: "down-regulation of isotype switching" EXACT [] +synonym: "downregulation of isotype switching" EXACT [] +synonym: "inhibition of isotype switching" NARROW [] +synonym: "negative regulation of class switch recombination" EXACT [] +synonym: "negative regulation of class switching" EXACT [] +synonym: "negative regulation of isotype switch recombination" EXACT [] +is_a: GO:0002638 ! negative regulation of immunoglobulin production +is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response +is_a: GO:0045191 ! regulation of isotype switching +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:0050869 ! negative regulation of B cell activation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045830 +name: positive regulation of isotype switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching." [GOC:go_curators] +synonym: "activation of isotype switching" NARROW [] +synonym: "positive regulation of class switch recombination" EXACT [] +synonym: "positive regulation of class switching" EXACT [] +synonym: "positive regulation of isotype switch recombination" EXACT [] +synonym: "stimulation of isotype switching" NARROW [] +synonym: "up regulation of isotype switching" EXACT [] +synonym: "up-regulation of isotype switching" EXACT [] +synonym: "upregulation of isotype switching" EXACT [] +is_a: GO:0002639 ! positive regulation of immunoglobulin production +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:0045191 ! regulation of isotype switching +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:0050871 ! positive regulation of B cell activation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0045190 ! isotype switching + +[Term] +id: GO:0045831 +name: negative regulation of light-activated channel activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +synonym: "down regulation of light-activated channel activity" EXACT [] +synonym: "down-regulation of light-activated channel activity" EXACT [] +synonym: "downregulation of light-activated channel activity" EXACT [] +synonym: "inhibition of light-activated channel activity" NARROW [] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity + +[Term] +id: GO:0045832 +name: positive regulation of light-activated channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] +synonym: "activation of light-activated channel activity" NARROW [] +synonym: "stimulation of light-activated channel activity" NARROW [] +synonym: "up regulation of light-activated channel activity" EXACT [] +synonym: "up-regulation of light-activated channel activity" EXACT [] +synonym: "upregulation of light-activated channel activity" EXACT [] +is_a: GO:0016061 ! regulation of light-activated channel activity +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity + +[Term] +id: GO:0045833 +name: negative regulation of lipid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +synonym: "down regulation of lipid metabolic process" EXACT [] +synonym: "down-regulation of lipid metabolic process" EXACT [] +synonym: "downregulation of lipid metabolic process" EXACT [] +synonym: "inhibition of lipid metabolic process" NARROW [] +synonym: "negative regulation of lipid metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: negatively_regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0045834 +name: positive regulation of lipid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] +synonym: "activation of lipid metabolic process" NARROW [] +synonym: "positive regulation of lipid metabolism" EXACT [] +synonym: "stimulation of lipid metabolic process" NARROW [] +synonym: "up regulation of lipid metabolic process" EXACT [] +synonym: "up-regulation of lipid metabolic process" EXACT [] +synonym: "upregulation of lipid metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: positively_regulates GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0045835 +name: negative regulation of meiotic nuclear division +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis." [GOC:go_curators] +synonym: "down regulation of meiosis" EXACT [] +synonym: "down-regulation of meiosis" EXACT [] +synonym: "downregulation of meiosis" EXACT [] +synonym: "inhibition of meiosis" NARROW [] +synonym: "negative regulation of meiosis" EXACT [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0040020 ! regulation of meiotic nuclear division +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +is_a: GO:0051784 ! negative regulation of nuclear division +relationship: negatively_regulates GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0045836 +name: positive regulation of meiotic nuclear division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiosis." [GOC:go_curators] +synonym: "activation of meiosis" NARROW [] +synonym: "positive regulation of meiosis" EXACT [] +synonym: "stimulation of meiosis" NARROW [] +synonym: "up regulation of meiosis" EXACT [] +synonym: "up-regulation of meiosis" EXACT [] +synonym: "upregulation of meiosis" EXACT [] +is_a: GO:0040020 ! regulation of meiotic nuclear division +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:0051785 ! positive regulation of nuclear division +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0045837 +name: negative regulation of membrane potential +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] +synonym: "down regulation of membrane potential" EXACT [] +synonym: "down-regulation of membrane potential" EXACT [] +synonym: "downregulation of membrane potential" EXACT [] +synonym: "inhibition of membrane potential" NARROW [] +synonym: "reduction of membrane potential" EXACT [GOC:rph] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0045838 +name: positive regulation of membrane potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:go_curators] +synonym: "activation of membrane potential" NARROW [] +synonym: "elevation of membrane potential" EXACT [GOC:rph] +synonym: "stimulation of membrane potential" NARROW [] +synonym: "up regulation of membrane potential" EXACT [] +synonym: "up-regulation of membrane potential" EXACT [] +synonym: "upregulation of membrane potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0045839 +name: negative regulation of mitotic nuclear division +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of mitosis" EXACT [] +synonym: "down-regulation of mitosis" EXACT [] +synonym: "downregulation of mitosis" EXACT [] +synonym: "inhibition of mitosis" NARROW [] +synonym: "negative regulation of mitosis" EXACT [] +is_a: GO:0007088 ! regulation of mitotic nuclear division +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +is_a: GO:0051784 ! negative regulation of nuclear division +relationship: negatively_regulates GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0045840 +name: positive regulation of mitotic nuclear division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] +synonym: "activation of mitosis" NARROW [] +synonym: "mitogenic activity" NARROW [] +synonym: "positive regulation of mitosis" EXACT [] +synonym: "stimulation of mitosis" NARROW [] +synonym: "up regulation of mitosis" EXACT [] +synonym: "up-regulation of mitosis" EXACT [] +synonym: "upregulation of mitosis" EXACT [] +is_a: GO:0007088 ! regulation of mitotic nuclear division +is_a: GO:0051785 ! positive regulation of nuclear division +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0045841 +name: negative regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators] +synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] +is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition +is_a: GO:0045839 ! negative regulation of mitotic nuclear division +is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition +is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle +is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation +relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle + +[Term] +id: GO:0045842 +name: positive regulation of mitotic metaphase/anaphase transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:go_curators] +synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] +synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] +synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] +synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] +is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition +is_a: GO:0045840 ! positive regulation of mitotic nuclear division +is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation +is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition +is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle +relationship: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle + +[Term] +id: GO:0045843 +name: negative regulation of striated muscle tissue development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development." [GOC:go_curators] +synonym: "down regulation of striated muscle development" EXACT [] +synonym: "down-regulation of striated muscle development" EXACT [] +synonym: "downregulation of striated muscle development" EXACT [] +synonym: "inhibition of striated muscle development" NARROW [] +is_a: GO:0016202 ! regulation of striated muscle tissue development +is_a: GO:0048635 ! negative regulation of muscle organ development +is_a: GO:1901862 ! negative regulation of muscle tissue development +relationship: negatively_regulates GO:0014706 ! striated muscle tissue development + +[Term] +id: GO:0045844 +name: positive regulation of striated muscle tissue development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle development." [GOC:go_curators] +synonym: "activation of striated muscle development" NARROW [] +synonym: "stimulation of striated muscle development" NARROW [] +synonym: "up regulation of striated muscle development" EXACT [] +synonym: "up-regulation of striated muscle development" EXACT [] +synonym: "upregulation of striated muscle development" EXACT [] +is_a: GO:0016202 ! regulation of striated muscle tissue development +is_a: GO:0048636 ! positive regulation of muscle organ development +is_a: GO:1901863 ! positive regulation of muscle tissue development +relationship: positively_regulates GO:0014706 ! striated muscle tissue development + +[Term] +id: GO:0045847 +name: negative regulation of nitrogen utilization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +synonym: "down regulation of nitrogen utilization" EXACT [] +synonym: "down-regulation of nitrogen utilization" EXACT [] +synonym: "downregulation of nitrogen utilization" EXACT [] +synonym: "inhibition of nitrogen utilization" NARROW [] +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0045848 +name: positive regulation of nitrogen utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] +synonym: "activation of nitrogen utilization" NARROW [] +synonym: "stimulation of nitrogen utilization" NARROW [] +synonym: "up regulation of nitrogen utilization" EXACT [] +synonym: "up-regulation of nitrogen utilization" EXACT [] +synonym: "upregulation of nitrogen utilization" EXACT [] +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0019740 ! nitrogen utilization + +[Term] +id: GO:0045849 +name: negative regulation of nurse cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "down regulation of nurse cell apoptosis" EXACT [] +synonym: "down-regulation of nurse cell apoptosis" EXACT [] +synonym: "downregulation of nurse cell apoptosis" EXACT [] +synonym: "inhibition of nurse cell apoptosis" NARROW [] +synonym: "negative regulation of nurse cell apoptosis" NARROW [] +is_a: GO:0045477 ! regulation of nurse cell apoptotic process +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0045476 ! nurse cell apoptotic process + +[Term] +id: GO:0045850 +name: positive regulation of nurse cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis] +synonym: "activation of nurse cell apoptosis" NARROW [] +synonym: "positive regulation of nurse cell apoptosis" NARROW [] +synonym: "stimulation of nurse cell apoptosis" NARROW [] +synonym: "up regulation of nurse cell apoptosis" EXACT [] +synonym: "up-regulation of nurse cell apoptosis" EXACT [] +synonym: "upregulation of nurse cell apoptosis" EXACT [] +is_a: GO:0045477 ! regulation of nurse cell apoptotic process +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0045476 ! nurse cell apoptotic process + +[Term] +id: GO:0045851 +name: pH reduction +namespace: biological_process +def: "Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +synonym: "acidification" EXACT [] +is_a: GO:0006885 ! regulation of pH + +[Term] +id: GO:0045852 +name: pH elevation +namespace: biological_process +def: "Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion." [GOC:go_curators] +is_a: GO:0006885 ! regulation of pH + +[Term] +id: GO:0045853 +name: negative regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] +synonym: "down regulation of bicoid mRNA localization" EXACT [] +synonym: "down-regulation of bicoid mRNA localization" EXACT [] +synonym: "downregulation of bicoid mRNA localization" EXACT [] +synonym: "inhibition of bicoid mRNA localization" NARROW [] +synonym: "negative regulation of bicoid mRNA localisation" EXACT [GOC:mah] +is_a: GO:0008359 ! regulation of bicoid mRNA localization +is_a: GO:1904581 ! negative regulation of intracellular mRNA localization +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0045854 +name: positive regulation of bicoid mRNA localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:go_curators] +synonym: "activation of bicoid mRNA localization" NARROW [] +synonym: "positive regulation of bicoid mRNA localisation" EXACT [GOC:mah] +synonym: "stimulation of bicoid mRNA localization" NARROW [] +synonym: "up regulation of bicoid mRNA localization" EXACT [] +synonym: "up-regulation of bicoid mRNA localization" EXACT [] +synonym: "upregulation of bicoid mRNA localization" EXACT [] +is_a: GO:0008359 ! regulation of bicoid mRNA localization +is_a: GO:1903431 ! positive regulation of cell maturation +is_a: GO:1904582 ! positive regulation of intracellular mRNA localization +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0045450 ! bicoid mRNA localization + +[Term] +id: GO:0045855 +name: negative regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "down regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "down-regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "downregulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "inhibition of pole plasm oskar mRNA localization" NARROW [] +synonym: "negative regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +synonym: "negative regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] +is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization +is_a: GO:1904581 ! negative regulation of intracellular mRNA localization +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0045856 +name: positive regulation of pole plasm oskar mRNA localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:go_curators] +synonym: "activation of pole plasm oskar mRNA localization" NARROW [] +synonym: "positive regulation of oocyte pole plasm oskar mRNA localization" EXACT [] +synonym: "positive regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] +synonym: "stimulation of pole plasm oskar mRNA localization" NARROW [] +synonym: "up regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "up-regulation of pole plasm oskar mRNA localization" EXACT [] +synonym: "upregulation of pole plasm oskar mRNA localization" EXACT [] +is_a: GO:0007317 ! regulation of pole plasm oskar mRNA localization +is_a: GO:1904582 ! positive regulation of intracellular mRNA localization +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0045451 ! pole plasm oskar mRNA localization + +[Term] +id: GO:0045857 +name: obsolete negative regulation of molecular function, epigenetic +namespace: biological_process +def: "OBSOLETE. Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] +comment: This term was obsoleted because it is not an active process. +synonym: "down regulation of protein activity, epigenetic" EXACT [] +synonym: "down-regulation of protein activity, epigenetic" EXACT [] +synonym: "downregulation of protein activity, epigenetic" EXACT [] +synonym: "inhibition of protein activity, epigenetic" NARROW [] +synonym: "negative regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0045858 +name: obsolete positive regulation of molecular function, epigenetic +namespace: biological_process +def: "OBSOLETE. Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb] +comment: This term was obsoleted because it is not an active process. +synonym: "activation of protein activity, epigenetic" NARROW [] +synonym: "positive regulation of protein activity, epigenetic" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of protein activity, epigenetic" NARROW [] +synonym: "up regulation of protein activity, epigenetic" EXACT [] +synonym: "up-regulation of protein activity, epigenetic" EXACT [] +synonym: "upregulation of protein activity, epigenetic" EXACT [] +is_obsolete: true + +[Term] +id: GO:0045859 +name: regulation of protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:0045860 +name: positive regulation of protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase activity." [GOC:go_curators] +synonym: "stimulation of protein kinase activity" NARROW [] +synonym: "up regulation of protein kinase activity" EXACT [] +synonym: "up-regulation of protein kinase activity" EXACT [] +synonym: "upregulation of protein kinase activity" EXACT [] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0045861 +name: negative regulation of proteolysis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] +synonym: "down regulation of proteolysis" EXACT [] +synonym: "down-regulation of proteolysis" EXACT [] +synonym: "downregulation of proteolysis" EXACT [] +synonym: "inhibition of proteolysis" NARROW [] +synonym: "negative regulation of peptidolysis" EXACT [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +relationship: negatively_regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0045862 +name: positive regulation of proteolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] +synonym: "activation of proteolysis" NARROW [] +synonym: "positive regulation of peptidolysis" EXACT [] +synonym: "stimulation of proteolysis" NARROW [] +synonym: "up regulation of proteolysis" EXACT [] +synonym: "up-regulation of proteolysis" EXACT [] +synonym: "upregulation of proteolysis" EXACT [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +relationship: positively_regulates GO:0006508 ! proteolysis + +[Term] +id: GO:0045863 +name: negative regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +synonym: "down regulation of pteridine metabolic process" EXACT [] +synonym: "down-regulation of pteridine metabolic process" EXACT [] +synonym: "downregulation of pteridine metabolic process" EXACT [] +synonym: "inhibition of pteridine metabolic process" NARROW [] +synonym: "negative regulation of pteridine metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0045864 +name: positive regulation of pteridine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators] +synonym: "activation of pteridine metabolic process" NARROW [] +synonym: "positive regulation of pteridine metabolism" EXACT [] +synonym: "stimulation of pteridine metabolic process" NARROW [] +synonym: "up regulation of pteridine metabolic process" EXACT [] +synonym: "up-regulation of pteridine metabolic process" EXACT [] +synonym: "upregulation of pteridine metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0019889 ! pteridine metabolic process + +[Term] +id: GO:0045865 +name: obsolete regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] +comment: This term was made obsolete because it describes a substrate-specific process. +synonym: "regulation of recombination within rDNA repeats" EXACT [] +is_obsolete: true +replaced_by: GO:0000019 + +[Term] +id: GO:0045866 +name: obsolete positive regulation of recombination within rDNA repeats +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] +comment: This term was made obsolete because it describes a substrate-specific process. +synonym: "positive regulation of recombination within rDNA repeats" EXACT [] +is_obsolete: true +consider: GO:0045951 + +[Term] +id: GO:0045869 +name: negative regulation of single stranded viral RNA replication via double stranded DNA intermediate +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators] +synonym: "down regulation of retroviral genome replication" EXACT [] +synonym: "down-regulation of retroviral genome replication" EXACT [] +synonym: "downregulation of retroviral genome replication" EXACT [] +synonym: "inhibition of retroviral genome replication" NARROW [] +synonym: "negative regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] +synonym: "regulation of retroviral genome replication" RELATED [] +is_a: GO:0045071 ! negative regulation of viral genome replication +is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate +relationship: negatively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate + +[Term] +id: GO:0045870 +name: positive regulation of single stranded viral RNA replication via double stranded DNA intermediate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retroviral genome replication." [GOC:go_curators] +synonym: "activation of retroviral genome replication" NARROW [] +synonym: "positive regulation of retroviral genome replication" EXACT [GOC:bf, GOC:jl] +synonym: "stimulation of retroviral genome replication" NARROW [] +synonym: "up regulation of retroviral genome replication" EXACT [] +synonym: "up-regulation of retroviral genome replication" EXACT [] +synonym: "upregulation of retroviral genome replication" EXACT [] +is_a: GO:0045070 ! positive regulation of viral genome replication +is_a: GO:0045091 ! regulation of single stranded viral RNA replication via double stranded DNA intermediate +relationship: positively_regulates GO:0039692 ! single stranded viral RNA replication via double stranded DNA intermediate + +[Term] +id: GO:0045871 +name: obsolete negative regulation of rhodopsin gene expression +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] +comment: This term was obsoleted because it referes to a specific gene product. The gene product should be captured as an annotation extension using 'has input'. +synonym: "down regulation of rhodopsin gene activity" EXACT [] +synonym: "down-regulation of rhodopsin gene activity" EXACT [] +synonym: "downregulation of rhodopsin gene activity" EXACT [] +synonym: "inhibition of rhodopsin gene activity" NARROW [] +synonym: "negative regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0000122 + +[Term] +id: GO:0045872 +name: obsolete positive regulation of rhodopsin gene expression +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rhodopsin gene expression." [GOC:dph, GOC:go_curators, GOC:tb] +comment: This term was obsoleted because it referes to a specific gene product. The gene product should be captured as an annotation extension using 'has input'. +synonym: "activation of rhodopsin gene activity" NARROW [] +synonym: "positive regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of rhodopsin gene activity" NARROW [] +synonym: "up regulation of rhodopsin gene activity" EXACT [] +synonym: "up-regulation of rhodopsin gene activity" EXACT [] +synonym: "upregulation of rhodopsin gene activity" EXACT [] +is_obsolete: true +consider: GO:0045944 + +[Term] +id: GO:0045873 +name: negative regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "down regulation of sevenless signaling pathway" EXACT [] +synonym: "down-regulation of sevenless signaling pathway" EXACT [] +synonym: "downregulation of sevenless signaling pathway" EXACT [] +synonym: "inhibition of sevenless signaling pathway" NARROW [] +synonym: "negative regulation of sev signaling pathway" EXACT [] +synonym: "negative regulation of sevenless signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0045501 ! regulation of sevenless signaling pathway +is_a: GO:0045677 ! negative regulation of R7 cell differentiation +relationship: negatively_regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045874 +name: positive regulation of sevenless signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the sevenless signaling pathway." [GOC:go_curators] +synonym: "activation of sevenless signaling pathway" NARROW [] +synonym: "positive regulation of sev signaling pathway" EXACT [] +synonym: "positive regulation of sevenless signalling pathway" EXACT [] +synonym: "stimulation of sevenless signaling pathway" NARROW [] +synonym: "up regulation of sevenless signaling pathway" EXACT [] +synonym: "up-regulation of sevenless signaling pathway" EXACT [] +synonym: "upregulation of sevenless signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0045501 ! regulation of sevenless signaling pathway +relationship: positively_regulates GO:0045500 ! sevenless signaling pathway + +[Term] +id: GO:0045875 +name: negative regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +synonym: "down regulation of sister chromatid cohesion" EXACT [] +synonym: "down-regulation of sister chromatid cohesion" EXACT [] +synonym: "downregulation of sister chromatid cohesion" EXACT [] +synonym: "inhibition of sister chromatid cohesion" NARROW [] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0045876 +name: positive regulation of sister chromatid cohesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] +synonym: "activation of sister chromatid cohesion" NARROW [] +synonym: "stimulation of sister chromatid cohesion" NARROW [] +synonym: "up regulation of sister chromatid cohesion" EXACT [] +synonym: "up-regulation of sister chromatid cohesion" EXACT [] +synonym: "upregulation of sister chromatid cohesion" EXACT [] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0045879 +name: negative regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0045877 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "down regulation of smoothened signaling pathway" EXACT [] +synonym: "down-regulation of smoothened signaling pathway" EXACT [] +synonym: "downregulation of smoothened signaling pathway" EXACT [] +synonym: "inhibition of smoothened signaling pathway" NARROW [] +synonym: "negative regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "negative regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "negative regulation of smoothened activity" RELATED [] +synonym: "negative regulation of smoothened by patched" NARROW [] +synonym: "negative regulation of smoothened receptor activity by patched" RELATED [] +synonym: "negative regulation of smoothened signalling pathway" EXACT [] +is_a: GO:0008589 ! regulation of smoothened signaling pathway +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0045880 +name: positive regulation of smoothened signaling pathway +namespace: biological_process +alt_id: GO:0045878 +def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling." [GOC:go_curators] +synonym: "activation of smoothened signaling pathway" NARROW [] +synonym: "positive regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "positive regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "positive regulation of smoothened by patched" RELATED [] +synonym: "positive regulation of smoothened receptor activity by patched" RELATED [] +synonym: "positive regulation of smoothened signalling pathway" EXACT [] +synonym: "stimulation of smoothened signaling pathway" NARROW [] +synonym: "up regulation of smoothened signaling pathway" EXACT [] +synonym: "up-regulation of smoothened signaling pathway" EXACT [] +synonym: "upregulation of smoothened signaling pathway" EXACT [] +is_a: GO:0008589 ! regulation of smoothened signaling pathway +is_a: GO:0009967 ! positive regulation of signal transduction +relationship: positively_regulates GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0045881 +name: positive regulation of sporulation resulting in formation of a cellular spore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sporulation." [GOC:go_curators] +synonym: "activation of sporulation" NARROW [] +synonym: "stimulation of sporulation" NARROW [] +synonym: "up regulation of sporulation" EXACT [] +synonym: "up-regulation of sporulation" EXACT [] +synonym: "upregulation of sporulation" EXACT [] +is_a: GO:0042173 ! regulation of sporulation resulting in formation of a cellular spore +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0045597 ! positive regulation of cell differentiation +relationship: positively_regulates GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0045882 +name: negative regulation of sulfur utilization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +synonym: "down regulation of sulfur utilization" EXACT [] +synonym: "down-regulation of sulfur utilization" EXACT [] +synonym: "downregulation of sulfur utilization" EXACT [] +synonym: "inhibition of sulfur utilization" NARROW [] +synonym: "negative regulation of sulphur utilization" EXACT [] +is_a: GO:0006792 ! regulation of sulfur utilization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0045883 +name: positive regulation of sulfur utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sulfur utilization." [GOC:go_curators] +synonym: "activation of sulfur utilization" NARROW [] +synonym: "positive regulation of sulphur utilization" EXACT [] +synonym: "stimulation of sulfur utilization" NARROW [] +synonym: "up regulation of sulfur utilization" EXACT [] +synonym: "up-regulation of sulfur utilization" EXACT [] +synonym: "upregulation of sulfur utilization" EXACT [] +is_a: GO:0006792 ! regulation of sulfur utilization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0006791 ! sulfur utilization + +[Term] +id: GO:0045884 +name: obsolete regulation of survival gene product expression +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] +comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. +synonym: "regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] +synonym: "regulation of survival gene product expression" EXACT [] +synonym: "regulation of survival gene products" BROAD [] +is_obsolete: true + +[Term] +id: GO:0045885 +name: obsolete positive regulation of survival gene product expression +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] +comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. +synonym: "activation of survival gene product activity" BROAD [] +synonym: "positive regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] +synonym: "positive regulation of survival gene product expression" EXACT [] +synonym: "positive regulation of survival gene products" BROAD [] +synonym: "stimulation of survival gene product activity" NARROW [] +synonym: "up regulation of survival gene product activity" BROAD [] +synonym: "up-regulation of survival gene product activity" BROAD [] +synonym: "upregulation of survival gene product activity" BROAD [] +is_obsolete: true + +[Term] +id: GO:0045886 +name: negative regulation of synaptic assembly at neuromuscular junction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic assembly at neuromuscular junction." [GOC:go_curators] +synonym: "down regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "down-regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "downregulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "inhibition of synaptic growth at neuromuscular junction" NARROW [] +synonym: "negative regulation of synaptic growth at neuromuscular junction" RELATED [] +is_a: GO:0008582 ! regulation of synaptic assembly at neuromuscular junction +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0051964 ! negative regulation of synapse assembly +is_a: GO:1904397 ! negative regulation of neuromuscular junction development +relationship: negatively_regulates GO:0051124 ! synaptic assembly at neuromuscular junction + +[Term] +id: GO:0045887 +name: positive regulation of synaptic assembly at neuromuscular junction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic assembly at neuromuscular junction." [GOC:go_curators] +synonym: "activation of synaptic growth at neuromuscular junction" NARROW [] +synonym: "positive regulation of synaptic growth at neuromuscular junction" RELATED [] +synonym: "stimulation of synaptic growth at neuromuscular junction" NARROW [] +synonym: "up regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "up-regulation of synaptic growth at neuromuscular junction" EXACT [] +synonym: "upregulation of synaptic growth at neuromuscular junction" EXACT [] +is_a: GO:0008582 ! regulation of synaptic assembly at neuromuscular junction +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0051965 ! positive regulation of synapse assembly +is_a: GO:1904398 ! positive regulation of neuromuscular junction development +relationship: positively_regulates GO:0051124 ! synaptic assembly at neuromuscular junction + +[Term] +id: GO:0045888 +name: obsolete regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "regulation of transcription of homeotic gene (Polycomb group)" EXACT [] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0045889 +name: obsolete positive regulation of transcription of homeotic gene (Polycomb group) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "positive regulation of transcription of homeotic gene (Polycomb group)" EXACT [] +is_obsolete: true +consider: GO:0045944 + +[Term] +id: GO:0045890 +name: obsolete regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "regulation of transcription of homeotic gene (trithorax group)" EXACT [] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0045891 +name: obsolete negative regulation of transcription of homeotic gene (trithorax group) +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] +comment: This term was made obsolete because it relates to a specific gene family rather than a process. +synonym: "negative regulation of transcription of homeotic gene (trithorax group)" EXACT [] +is_obsolete: true +consider: GO:0000122 + +[Term] +id: GO:0045892 +name: negative regulation of transcription, DNA-templated +namespace: biological_process +alt_id: GO:0016481 +alt_id: GO:0032582 +alt_id: GO:0061021 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +synonym: "down regulation of gene-specific transcription" RELATED [] +synonym: "down regulation of transcription, DNA-dependent" EXACT [] +synonym: "down-regulation of gene-specific transcription" RELATED [] +synonym: "down-regulation of transcription, DNA-dependent" EXACT [] +synonym: "downregulation of gene-specific transcription" RELATED [] +synonym: "downregulation of transcription, DNA-dependent" EXACT [] +synonym: "inhibition of gene-specific transcription" RELATED [] +synonym: "inhibition of transcription, DNA-dependent" NARROW [] +synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] +synonym: "negative regulation of gene-specific transcription" RELATED [] +synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] +synonym: "transcription repressor activity" RELATED [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription +relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0045893 +name: positive regulation of transcription, DNA-templated +namespace: biological_process +alt_id: GO:0043193 +alt_id: GO:0045941 +alt_id: GO:0061020 +def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +synonym: "activation of gene-specific transcription" RELATED [] +synonym: "activation of transcription, DNA-dependent" NARROW [] +synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] +synonym: "positive regulation of gene-specific transcription" RELATED [] +synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] +synonym: "stimulation of gene-specific transcription" NARROW [] +synonym: "stimulation of transcription, DNA-dependent" NARROW [] +synonym: "transcription activator activity" RELATED [] +synonym: "up regulation of gene-specific transcription" RELATED [] +synonym: "up regulation of transcription, DNA-dependent" EXACT [] +synonym: "up-regulation of gene-specific transcription" RELATED [] +synonym: "up-regulation of transcription, DNA-dependent" EXACT [] +synonym: "upregulation of gene-specific transcription" RELATED [] +synonym: "upregulation of transcription, DNA-dependent" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription +relationship: positively_regulates GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0045894 +name: negative regulation of mating-type specific transcription, DNA-templated +namespace: biological_process +def: "Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +synonym: "down regulation of transcription, mating-type specific" EXACT [] +synonym: "down-regulation of transcription, mating-type specific" EXACT [] +synonym: "downregulation of transcription, mating-type specific" EXACT [] +synonym: "inhibition of transcription, mating-type specific" NARROW [] +synonym: "negative regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] +is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0045895 +name: positive regulation of mating-type specific transcription, DNA-templated +namespace: biological_process +def: "Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] +synonym: "activation of transcription, mating-type specific" NARROW [] +synonym: "positive regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] +synonym: "stimulation of transcription, mating-type specific" NARROW [] +synonym: "up regulation of transcription, mating-type specific" EXACT [] +synonym: "up-regulation of transcription, mating-type specific" EXACT [] +synonym: "upregulation of transcription, mating-type specific" EXACT [] +is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated + +[Term] +id: GO:0045896 +name: obsolete regulation of transcription during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "mitotic regulation of transcription" EXACT [] +synonym: "regulation of transcription, mitotic" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0006357 +consider: GO:0044772 + +[Term] +id: GO:0045897 +name: obsolete positive regulation of transcription during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "activation of transcription during mitosis" NARROW [GOC:mah] +synonym: "mitotic activation of transcription" EXACT [] +synonym: "positive regulation of transcription, mitotic" EXACT [GOC:mah] +synonym: "stimulation of transcription during mitosis" NARROW [GOC:mah] +synonym: "up regulation of transcription during mitosis" EXACT [GOC:mah] +synonym: "up-regulation of transcription during mitosis" EXACT [GOC:mah] +synonym: "upregulation of transcription during mitosis" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0044772 +consider: GO:0045944 + +[Term] +id: GO:0045898 +name: regulation of RNA polymerase II transcription preinitiation complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] +synonym: "regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "regulation of RNA polymerase II transcriptional preinitiation complex formation" RELATED [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter +relationship: regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly + +[Term] +id: GO:0045899 +name: positive regulation of RNA polymerase II transcription preinitiation complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] +synonym: "activation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] +synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] +synonym: "positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] +synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "positive regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] +synonym: "stimulation of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] +synonym: "up regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "up-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "upregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0045898 ! regulation of RNA polymerase II transcription preinitiation complex assembly +is_a: GO:0060261 ! positive regulation of transcription initiation from RNA polymerase II promoter +relationship: positively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly + +[Term] +id: GO:0045900 +name: negative regulation of translational elongation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation." [GOC:go_curators] +synonym: "down regulation of translational elongation" EXACT [] +synonym: "down-regulation of translational elongation" EXACT [] +synonym: "downregulation of translational elongation" EXACT [] +synonym: "inhibition of translational elongation" NARROW [] +is_a: GO:0006448 ! regulation of translational elongation +is_a: GO:0017148 ! negative regulation of translation +relationship: negatively_regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0045901 +name: positive regulation of translational elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational elongation." [GOC:go_curators] +synonym: "activation of translational elongation" NARROW [] +synonym: "stimulation of translational elongation" NARROW [] +synonym: "up regulation of translational elongation" EXACT [] +synonym: "up-regulation of translational elongation" EXACT [] +synonym: "upregulation of translational elongation" EXACT [] +is_a: GO:0006448 ! regulation of translational elongation +is_a: GO:0045727 ! positive regulation of translation +relationship: positively_regulates GO:0006414 ! translational elongation + +[Term] +id: GO:0045902 +name: negative regulation of translational fidelity +namespace: biological_process +def: "Any process that decreases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +synonym: "down regulation of translational fidelity" EXACT [] +synonym: "down-regulation of translational fidelity" EXACT [] +synonym: "downregulation of translational fidelity" EXACT [] +synonym: "inhibition of translational fidelity" NARROW [] +is_a: GO:0006450 ! regulation of translational fidelity +is_a: GO:0017148 ! negative regulation of translation + +[Term] +id: GO:0045903 +name: positive regulation of translational fidelity +namespace: biological_process +def: "Any process that increases the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] +synonym: "activation of translational fidelity" NARROW [] +synonym: "stimulation of translational fidelity" NARROW [] +synonym: "up regulation of translational fidelity" EXACT [] +synonym: "up-regulation of translational fidelity" EXACT [] +synonym: "upregulation of translational fidelity" EXACT [] +is_a: GO:0006450 ! regulation of translational fidelity +is_a: GO:0045727 ! positive regulation of translation + +[Term] +id: GO:0045904 +name: negative regulation of translational termination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination." [GOC:go_curators] +synonym: "down regulation of translational termination" EXACT [] +synonym: "down-regulation of translational termination" EXACT [] +synonym: "downregulation of translational termination" EXACT [] +synonym: "inhibition of translational termination" NARROW [] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +relationship: negatively_regulates GO:0006415 ! translational termination + +[Term] +id: GO:0045905 +name: positive regulation of translational termination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational termination." [GOC:go_curators] +synonym: "activation of translational termination" NARROW [] +synonym: "stimulation of translational termination" NARROW [] +synonym: "up regulation of translational termination" EXACT [] +synonym: "up-regulation of translational termination" EXACT [] +synonym: "upregulation of translational termination" EXACT [] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly +is_a: GO:0045727 ! positive regulation of translation +relationship: positively_regulates GO:0006415 ! translational termination + +[Term] +id: GO:0045906 +name: negative regulation of vasoconstriction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vasoconstriction." [GOC:go_curators] +synonym: "down regulation of vasoconstriction" EXACT [] +synonym: "down-regulation of vasoconstriction" EXACT [] +synonym: "downregulation of vasoconstriction" EXACT [] +synonym: "inhibition of vasoconstriction" NARROW [] +is_a: GO:0019229 ! regulation of vasoconstriction +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0045907 +name: positive regulation of vasoconstriction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vasoconstriction." [GOC:go_curators] +synonym: "activation of vasoconstriction" NARROW [] +synonym: "stimulation of vasoconstriction" NARROW [] +synonym: "up regulation of vasoconstriction" EXACT [] +synonym: "up-regulation of vasoconstriction" EXACT [] +synonym: "upregulation of vasoconstriction" EXACT [] +is_a: GO:0019229 ! regulation of vasoconstriction +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0042310 ! vasoconstriction + +[Term] +id: GO:0045910 +name: negative regulation of DNA recombination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination." [GOC:go_curators] +synonym: "down regulation of DNA recombination" EXACT [] +synonym: "down-regulation of DNA recombination" EXACT [] +synonym: "downregulation of DNA recombination" EXACT [] +synonym: "inhibition of DNA recombination" NARROW [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0045911 +name: positive regulation of DNA recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination." [GOC:go_curators] +synonym: "activation of DNA recombination" NARROW [] +synonym: "stimulation of DNA recombination" NARROW [] +synonym: "up regulation of DNA recombination" EXACT [] +synonym: "up-regulation of DNA recombination" EXACT [] +synonym: "upregulation of DNA recombination" EXACT [] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0006310 ! DNA recombination + +[Term] +id: GO:0045912 +name: negative regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] +synonym: "down regulation of carbohydrate metabolic process" EXACT [] +synonym: "down-regulation of carbohydrate metabolic process" EXACT [] +synonym: "downregulation of carbohydrate metabolic process" EXACT [] +synonym: "inhibition of carbohydrate metabolic process" NARROW [] +synonym: "negative regulation of carbohydrate metabolism" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009892 ! negative regulation of metabolic process +relationship: negatively_regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0045913 +name: positive regulation of carbohydrate metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate." [GOC:go_curators] +synonym: "activation of carbohydrate metabolic process" NARROW [] +synonym: "positive regulation of carbohydrate metabolism" EXACT [] +synonym: "stimulation of carbohydrate metabolic process" NARROW [] +synonym: "up regulation of carbohydrate metabolic process" EXACT [] +synonym: "up-regulation of carbohydrate metabolic process" EXACT [] +synonym: "upregulation of carbohydrate metabolic process" EXACT [] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +is_a: GO:0009893 ! positive regulation of metabolic process +relationship: positively_regulates GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0045914 +name: negative regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] +synonym: "down regulation of catecholamine metabolic process" EXACT [] +synonym: "down-regulation of catecholamine metabolic process" EXACT [] +synonym: "downregulation of catecholamine metabolic process" EXACT [] +synonym: "inhibition of catecholamine metabolic process" NARROW [] +synonym: "negative regulation of catecholamine metabolism" EXACT [] +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: negatively_regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0045915 +name: positive regulation of catecholamine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine." [GOC:go_curators] +synonym: "activation of catecholamine metabolic process" NARROW [] +synonym: "positive regulation of catecholamine metabolism" EXACT [] +synonym: "stimulation of catecholamine metabolic process" NARROW [] +synonym: "up regulation of catecholamine metabolic process" EXACT [] +synonym: "up-regulation of catecholamine metabolic process" EXACT [] +synonym: "upregulation of catecholamine metabolic process" EXACT [] +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0042069 ! regulation of catecholamine metabolic process +relationship: positively_regulates GO:0006584 ! catecholamine metabolic process + +[Term] +id: GO:0045916 +name: negative regulation of complement activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation." [GOC:go_curators] +synonym: "down regulation of complement activation" EXACT [] +synonym: "down-regulation of complement activation" EXACT [] +synonym: "downregulation of complement activation" EXACT [] +synonym: "inhibition of complement activation" NARROW [] +synonym: "negative regulation of complement cascade" EXACT [GOC:add] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0002921 ! negative regulation of humoral immune response +is_a: GO:0030449 ! regulation of complement activation +relationship: negatively_regulates GO:0006956 ! complement activation + +[Term] +id: GO:0045917 +name: positive regulation of complement activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation." [GOC:go_curators] +synonym: "activation of complement activation" NARROW [] +synonym: "positive regulation of complement cascade" EXACT [GOC:add] +synonym: "stimulation of complement activation" NARROW [] +synonym: "up regulation of complement activation" EXACT [] +synonym: "up-regulation of complement activation" EXACT [] +synonym: "upregulation of complement activation" EXACT [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002922 ! positive regulation of humoral immune response +is_a: GO:0030449 ! regulation of complement activation +relationship: positively_regulates GO:0006956 ! complement activation + +[Term] +id: GO:0045918 +name: negative regulation of cytolysis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytolysis." [GOC:go_curators] +synonym: "down regulation of cytolysis" EXACT [] +synonym: "down-regulation of cytolysis" EXACT [] +synonym: "downregulation of cytolysis" EXACT [] +synonym: "inhibition of cytolysis" NARROW [] +is_a: GO:0042268 ! regulation of cytolysis +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0045919 +name: positive regulation of cytolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytolysis." [GOC:go_curators] +synonym: "activation of cytolysis" NARROW [] +synonym: "stimulation of cytolysis" NARROW [] +synonym: "up regulation of cytolysis" EXACT [] +synonym: "up-regulation of cytolysis" EXACT [] +synonym: "upregulation of cytolysis" EXACT [] +is_a: GO:0042268 ! regulation of cytolysis +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0019835 ! cytolysis + +[Term] +id: GO:0045920 +name: negative regulation of exocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis." [GOC:go_curators] +synonym: "down regulation of exocytosis" EXACT [] +synonym: "down-regulation of exocytosis" EXACT [] +synonym: "downregulation of exocytosis" EXACT [] +synonym: "inhibition of exocytosis" NARROW [] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0045921 +name: positive regulation of exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exocytosis." [GOC:go_curators] +synonym: "activation of exocytosis" NARROW [] +synonym: "stimulation of exocytosis" NARROW [] +synonym: "up regulation of exocytosis" EXACT [] +synonym: "up-regulation of exocytosis" EXACT [] +synonym: "upregulation of exocytosis" EXACT [] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0006887 ! exocytosis + +[Term] +id: GO:0045922 +name: negative regulation of fatty acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +synonym: "down regulation of fatty acid metabolic process" EXACT [] +synonym: "down-regulation of fatty acid metabolic process" EXACT [] +synonym: "downregulation of fatty acid metabolic process" EXACT [] +synonym: "inhibition of fatty acid metabolic process" NARROW [] +synonym: "negative regulation of fatty acid metabolism" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0045923 +name: positive regulation of fatty acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] +synonym: "activation of fatty acid metabolic process" NARROW [] +synonym: "positive regulation of fatty acid metabolism" EXACT [] +synonym: "stimulation of fatty acid metabolic process" NARROW [] +synonym: "up regulation of fatty acid metabolic process" EXACT [] +synonym: "up-regulation of fatty acid metabolic process" EXACT [] +synonym: "upregulation of fatty acid metabolic process" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0045924 +name: regulation of female receptivity +namespace: biological_process +alt_id: GO:0060181 +def: "Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "female receptivity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0060180 ! female mating behavior +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0045925 +name: positive regulation of female receptivity +namespace: biological_process +def: "Any process that activates or increases the receptiveness of a female to male advances." [GOC:go_curators] +synonym: "activation of female receptivity" NARROW [] +synonym: "stimulation of female receptivity" NARROW [] +synonym: "up regulation of female receptivity" EXACT [] +synonym: "up-regulation of female receptivity" EXACT [] +synonym: "upregulation of female receptivity" EXACT [] +is_a: GO:0045924 ! regulation of female receptivity + +[Term] +id: GO:0045926 +name: negative regulation of growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] +synonym: "down regulation of growth" EXACT [] +synonym: "down-regulation of growth" EXACT [] +synonym: "downregulation of growth" EXACT [] +synonym: "inhibition of growth" NARROW [] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0040007 ! growth + +[Term] +id: GO:0045927 +name: positive regulation of growth +namespace: biological_process +def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] +synonym: "activation of growth" NARROW [] +synonym: "stimulation of growth" NARROW [] +synonym: "up regulation of growth" EXACT [] +synonym: "up-regulation of growth" EXACT [] +synonym: "upregulation of growth" EXACT [] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0040007 ! growth + +[Term] +id: GO:0045928 +name: negative regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone metabolic process" EXACT [] +synonym: "down-regulation of juvenile hormone metabolic process" EXACT [] +synonym: "downregulation of juvenile hormone metabolic process" EXACT [] +synonym: "inhibition of juvenile hormone metabolic process" NARROW [] +synonym: "negative regulation of juvenile hormone metabolism" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +relationship: negatively_regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0045929 +name: positive regulation of juvenile hormone metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone metabolic process" NARROW [] +synonym: "positive regulation of juvenile hormone metabolism" EXACT [] +synonym: "stimulation of juvenile hormone metabolic process" NARROW [] +synonym: "up regulation of juvenile hormone metabolic process" EXACT [] +synonym: "up-regulation of juvenile hormone metabolic process" EXACT [] +synonym: "upregulation of juvenile hormone metabolic process" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +relationship: positively_regulates GO:0006716 ! juvenile hormone metabolic process + +[Term] +id: GO:0045930 +name: negative regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through mitotic cell cycle" NARROW [] +synonym: "negative regulation of mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0045786 ! negative regulation of cell cycle +relationship: negatively_regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0045931 +name: positive regulation of mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through mitotic cell cycle" NARROW [] +synonym: "positive regulation of mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through mitotic cell cycle" EXACT [] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0045787 ! positive regulation of cell cycle +relationship: positively_regulates GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0045932 +name: negative regulation of muscle contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction." [GOC:go_curators] +synonym: "down regulation of muscle contraction" EXACT [] +synonym: "down-regulation of muscle contraction" EXACT [] +synonym: "downregulation of muscle contraction" EXACT [] +synonym: "inhibition of muscle contraction" NARROW [] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0045933 +name: positive regulation of muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle contraction." [GOC:go_curators] +synonym: "activation of muscle contraction" NARROW [] +synonym: "stimulation of muscle contraction" NARROW [] +synonym: "up regulation of muscle contraction" EXACT [] +synonym: "up-regulation of muscle contraction" EXACT [] +synonym: "upregulation of muscle contraction" EXACT [] +is_a: GO:0006937 ! regulation of muscle contraction +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0006936 ! muscle contraction + +[Term] +id: GO:0045934 +name: negative regulation of nucleobase-containing compound metabolic process +namespace: biological_process +def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process + +[Term] +id: GO:0045935 +name: positive regulation of nucleobase-containing compound metabolic process +namespace: biological_process +def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] +synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] +synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] +synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process + +[Term] +id: GO:0045936 +name: negative regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +synonym: "down regulation of phosphate metabolic process" EXACT [] +synonym: "down-regulation of phosphate metabolic process" EXACT [] +synonym: "downregulation of phosphate metabolic process" EXACT [] +synonym: "inhibition of phosphate metabolic process" NARROW [] +synonym: "negative regulation of phosphate metabolism" EXACT [] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: negatively_regulates GO:0006796 ! phosphate-containing compound metabolic process + +[Term] +id: GO:0045937 +name: positive regulation of phosphate metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] +synonym: "activation of phosphate metabolic process" NARROW [] +synonym: "positive regulation of phosphate metabolism" EXACT [] +synonym: "stimulation of phosphate metabolic process" NARROW [] +synonym: "up regulation of phosphate metabolic process" EXACT [] +synonym: "up-regulation of phosphate metabolic process" EXACT [] +synonym: "upregulation of phosphate metabolic process" EXACT [] +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: positively_regulates GO:0006796 ! phosphate-containing compound metabolic process + +[Term] +id: GO:0045938 +name: positive regulation of circadian sleep/wake cycle, sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "positive regulation of sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, sleep" EXACT [] +is_a: GO:0042753 ! positive regulation of circadian rhythm +is_a: GO:0045187 ! regulation of circadian sleep/wake cycle, sleep +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050802 ! circadian sleep/wake cycle, sleep + +[Term] +id: GO:0045939 +name: negative regulation of steroid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +synonym: "down regulation of steroid metabolic process" EXACT [] +synonym: "down-regulation of steroid metabolic process" EXACT [] +synonym: "downregulation of steroid metabolic process" EXACT [] +synonym: "inhibition of steroid metabolic process" NARROW [] +synonym: "negative regulation of steroid metabolism" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +relationship: negatively_regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0045940 +name: positive regulation of steroid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] +synonym: "activation of steroid metabolic process" NARROW [] +synonym: "positive regulation of steroid metabolism" EXACT [] +synonym: "stimulation of steroid metabolic process" NARROW [] +synonym: "up regulation of steroid metabolic process" EXACT [] +synonym: "up-regulation of steroid metabolic process" EXACT [] +synonym: "upregulation of steroid metabolic process" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +relationship: positively_regulates GO:0008202 ! steroid metabolic process + +[Term] +id: GO:0045942 +name: negative regulation of phosphorus utilization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +synonym: "down regulation of phosphorus utilization" EXACT [] +synonym: "down-regulation of phosphorus utilization" EXACT [] +synonym: "downregulation of phosphorus utilization" EXACT [] +synonym: "inhibition of phosphorus utilization" NARROW [] +is_a: GO:0006795 ! regulation of phosphorus utilization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0045943 +name: positive regulation of transcription by RNA polymerase I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators, GOC:txnOH] +synonym: "activation of transcription from RNA polymerase I promoter" NARROW [] +synonym: "positive regulation of transcription from Pol I promoter" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "stimulation of transcription from RNA polymerase I promoter" NARROW [] +synonym: "up regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase I promoter" EXACT [] +synonym: "upregulation of transcription from RNA polymerase I promoter" EXACT [] +is_a: GO:0006356 ! regulation of transcription by RNA polymerase I +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: positively_regulates GO:0006360 ! transcription by RNA polymerase I + +[Term] +id: GO:0045944 +name: positive regulation of transcription by RNA polymerase II +namespace: biological_process +alt_id: GO:0010552 +alt_id: GO:0045817 +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] +synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] +synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] +synonym: "positive regulation of transcription from Pol II promoter" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] +synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] +synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] +synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: positively_regulates GO:0006366 ! transcription by RNA polymerase II + +[Term] +id: GO:0045945 +name: positive regulation of transcription by RNA polymerase III +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators, GOC:txnOH] +synonym: "activation of transcription from RNA polymerase III promoter" NARROW [] +synonym: "positive regulation of transcription from Pol III promoter" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "stimulation of transcription from RNA polymerase III promoter" NARROW [] +synonym: "up regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "up-regulation of transcription from RNA polymerase III promoter" EXACT [] +synonym: "upregulation of transcription from RNA polymerase III promoter" EXACT [] +is_a: GO:0006359 ! regulation of transcription by RNA polymerase III +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: positively_regulates GO:0006383 ! transcription by RNA polymerase III + +[Term] +id: GO:0045947 +name: negative regulation of translational initiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation." [GOC:go_curators] +synonym: "down regulation of translational initiation" EXACT [] +synonym: "down-regulation of translational initiation" EXACT [] +synonym: "downregulation of translational initiation" EXACT [] +synonym: "inhibition of translational initiation" NARROW [] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0017148 ! negative regulation of translation +relationship: negatively_regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0045948 +name: positive regulation of translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational initiation." [GOC:go_curators] +synonym: "activation of translational initiation" NARROW [] +synonym: "stimulation of translational initiation" NARROW [] +synonym: "up regulation of translational initiation" EXACT [] +synonym: "up-regulation of translational initiation" EXACT [] +synonym: "upregulation of translational initiation" EXACT [] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0045727 ! positive regulation of translation +relationship: positively_regulates GO:0006413 ! translational initiation + +[Term] +id: GO:0045949 +name: positive regulation of phosphorus utilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] +synonym: "activation of phosphorus utilization" NARROW [] +synonym: "stimulation of phosphorus utilization" NARROW [] +synonym: "up regulation of phosphorus utilization" EXACT [] +synonym: "up-regulation of phosphorus utilization" EXACT [] +synonym: "upregulation of phosphorus utilization" EXACT [] +is_a: GO:0006795 ! regulation of phosphorus utilization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0006794 ! phosphorus utilization + +[Term] +id: GO:0045950 +name: negative regulation of mitotic recombination +namespace: biological_process +def: "Any process that inhibits or decreases the rate of DNA recombination during mitosis." [GOC:go_curators, GOC:hjd] +synonym: "down regulation of mitotic recombination" EXACT [] +synonym: "down-regulation of mitotic recombination" EXACT [] +synonym: "downregulation of mitotic recombination" EXACT [] +synonym: "inhibition of mitotic recombination" NARROW [] +synonym: "negative regulation of recombination within rDNA repeats" NARROW [] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0045910 ! negative regulation of DNA recombination +relationship: negatively_regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0045951 +name: positive regulation of mitotic recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] +synonym: "activation of mitotic recombination" NARROW [] +synonym: "positive regulation of recombination within rDNA repeats" NARROW [] +synonym: "stimulation of mitotic recombination" NARROW [] +synonym: "up regulation of mitotic recombination" EXACT [] +synonym: "up-regulation of mitotic recombination" EXACT [] +synonym: "upregulation of mitotic recombination" EXACT [] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0045911 ! positive regulation of DNA recombination +relationship: positively_regulates GO:0006312 ! mitotic recombination + +[Term] +id: GO:0045952 +name: regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "regulation of juvenile hormone breakdown" EXACT [] +synonym: "regulation of juvenile hormone catabolism" EXACT [] +synonym: "regulation of juvenile hormone degradation" EXACT [] +is_a: GO:0007556 ! regulation of juvenile hormone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045953 +name: negative regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "down regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "down-regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "downregulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "inhibition of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "negative regulation of natural killer cell mediated cell death" EXACT [] +synonym: "negative regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "negative regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "negative regulation of NK cell mediated cell death" EXACT [] +synonym: "negative regulation of NK cell mediated cell killing" EXACT [] +synonym: "negative regulation of NK cell mediated cytolysis" RELATED [] +synonym: "negative regulation of NK cell mediated cytotoxicity" EXACT [] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: negatively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0045954 +name: positive regulation of natural killer cell mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] +synonym: "activation of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "positive regulation of natural killer cell mediated cell death" EXACT [] +synonym: "positive regulation of natural killer cell mediated cell killing" EXACT [] +synonym: "positive regulation of natural killer cell mediated cytolysis" RELATED [] +synonym: "positive regulation of NK cell mediated cell death" EXACT [] +synonym: "positive regulation of NK cell mediated cell killing" EXACT [] +synonym: "positive regulation of NK cell mediated cytolysis" RELATED [] +synonym: "positive regulation of NK cell mediated cytotoxicity" EXACT [] +synonym: "stimulation of natural killer cell mediated cytotoxicity" NARROW [] +synonym: "up regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "up-regulation of natural killer cell mediated cytotoxicity" EXACT [] +synonym: "upregulation of natural killer cell mediated cytotoxicity" EXACT [] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity +is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity +relationship: positively_regulates GO:0042267 ! natural killer cell mediated cytotoxicity + +[Term] +id: GO:0045955 +name: negative regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +synonym: "down regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "down-regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "downregulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "inhibition of calcium ion-dependent exocytosis" NARROW [] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:1903306 ! negative regulation of regulated secretory pathway +relationship: negatively_regulates GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:0045956 +name: positive regulation of calcium ion-dependent exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] +synonym: "activation of calcium ion-dependent exocytosis" NARROW [] +synonym: "stimulation of calcium ion-dependent exocytosis" NARROW [] +synonym: "up regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "up-regulation of calcium ion-dependent exocytosis" EXACT [] +synonym: "upregulation of calcium ion-dependent exocytosis" EXACT [] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:1903307 ! positive regulation of regulated secretory pathway +relationship: positively_regulates GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:0045957 +name: negative regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] +synonym: "down regulation of complement activation, alternative pathway" EXACT [] +synonym: "down-regulation of complement activation, alternative pathway" EXACT [] +synonym: "downregulation of complement activation, alternative pathway" EXACT [] +synonym: "inhibition of complement activation, alternative pathway" NARROW [] +synonym: "negative regulation of complement cascade, alternative pathway" EXACT [GOC:add] +is_a: GO:0030451 ! regulation of complement activation, alternative pathway +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0045958 +name: positive regulation of complement activation, alternative pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway." [GOC:go_curators] +synonym: "activation of complement activation, alternative pathway" NARROW [] +synonym: "positive regulation of complement cascade, alternative pathway" EXACT [GOC:add] +synonym: "stimulation of complement activation, alternative pathway" NARROW [] +synonym: "up regulation of complement activation, alternative pathway" EXACT [] +synonym: "up-regulation of complement activation, alternative pathway" EXACT [] +synonym: "upregulation of complement activation, alternative pathway" EXACT [] +is_a: GO:0030451 ! regulation of complement activation, alternative pathway +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0006957 ! complement activation, alternative pathway + +[Term] +id: GO:0045959 +name: negative regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] +synonym: "down regulation of complement activation, classical pathway" EXACT [] +synonym: "down-regulation of complement activation, classical pathway" EXACT [] +synonym: "downregulation of complement activation, classical pathway" EXACT [] +synonym: "inhibition of complement activation, classical pathway" NARROW [] +synonym: "negative regulation of complement cascade, classical pathway" EXACT [GOC:add] +is_a: GO:0002924 ! negative regulation of humoral immune response mediated by circulating immunoglobulin +is_a: GO:0030450 ! regulation of complement activation, classical pathway +is_a: GO:0045916 ! negative regulation of complement activation +relationship: negatively_regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0045960 +name: positive regulation of complement activation, classical pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway." [GOC:go_curators] +synonym: "activation of complement activation, classical pathway" NARROW [] +synonym: "positive regulation of complement cascade, classical pathway" EXACT [GOC:add] +synonym: "stimulation of complement activation, classical pathway" NARROW [] +synonym: "up regulation of complement activation, classical pathway" EXACT [] +synonym: "up-regulation of complement activation, classical pathway" EXACT [] +synonym: "upregulation of complement activation, classical pathway" EXACT [] +is_a: GO:0002925 ! positive regulation of humoral immune response mediated by circulating immunoglobulin +is_a: GO:0030450 ! regulation of complement activation, classical pathway +is_a: GO:0045917 ! positive regulation of complement activation +relationship: positively_regulates GO:0006958 ! complement activation, classical pathway + +[Term] +id: GO:0045961 +name: negative regulation of development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [GOC:go_curators] +synonym: "down regulation of development, heterochronic" EXACT [] +synonym: "down-regulation of development, heterochronic" EXACT [] +synonym: "downregulation of development, heterochronic" EXACT [] +synonym: "inhibition of development, heterochronic" NARROW [] +is_a: GO:0040034 ! regulation of development, heterochronic + +[Term] +id: GO:0045962 +name: positive regulation of development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [GOC:go_curators] +synonym: "activation of development, heterochronic" NARROW [] +synonym: "stimulation of development, heterochronic" NARROW [] +synonym: "up regulation of development, heterochronic" EXACT [] +synonym: "up-regulation of development, heterochronic" EXACT [] +synonym: "upregulation of development, heterochronic" EXACT [] +is_a: GO:0040034 ! regulation of development, heterochronic + +[Term] +id: GO:0045963 +name: negative regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "down regulation of dopamine metabolic process" EXACT [] +synonym: "down-regulation of dopamine metabolic process" EXACT [] +synonym: "downregulation of dopamine metabolic process" EXACT [] +synonym: "inhibition of dopamine metabolic process" NARROW [] +synonym: "negative regulation of dopamine metabolism" EXACT [] +is_a: GO:0042053 ! regulation of dopamine metabolic process +is_a: GO:0045914 ! negative regulation of catecholamine metabolic process +relationship: negatively_regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0045964 +name: positive regulation of dopamine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators] +synonym: "activation of dopamine metabolic process" NARROW [] +synonym: "positive regulation of dopamine metabolism" EXACT [] +synonym: "stimulation of dopamine metabolic process" NARROW [] +synonym: "up regulation of dopamine metabolic process" EXACT [] +synonym: "up-regulation of dopamine metabolic process" EXACT [] +synonym: "upregulation of dopamine metabolic process" EXACT [] +is_a: GO:0042053 ! regulation of dopamine metabolic process +is_a: GO:0045915 ! positive regulation of catecholamine metabolic process +relationship: positively_regulates GO:0042417 ! dopamine metabolic process + +[Term] +id: GO:0045965 +name: negative regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] +synonym: "down regulation of ecdysteroid metabolic process" EXACT [] +synonym: "down-regulation of ecdysteroid metabolic process" EXACT [] +synonym: "downregulation of ecdysteroid metabolic process" EXACT [] +synonym: "inhibition of ecdysteroid metabolic process" NARROW [] +synonym: "negative regulation of ecdysteroid metabolism" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0045966 +name: positive regulation of ecdysteroid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids." [GOC:go_curators] +synonym: "activation of ecdysteroid metabolic process" NARROW [] +synonym: "positive regulation of ecdysteroid metabolism" EXACT [] +synonym: "stimulation of ecdysteroid metabolic process" NARROW [] +synonym: "up regulation of ecdysteroid metabolic process" EXACT [] +synonym: "up-regulation of ecdysteroid metabolic process" EXACT [] +synonym: "upregulation of ecdysteroid metabolic process" EXACT [] +is_a: GO:0007553 ! regulation of ecdysteroid metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0045967 +name: negative regulation of growth rate +namespace: biological_process +def: "Any process that reduces the rate of growth of all or part of an organism." [GOC:mah] +comment: Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. +synonym: "down regulation of growth rate" EXACT [] +synonym: "down-regulation of growth rate" EXACT [] +synonym: "downregulation of growth rate" EXACT [] +synonym: "inhibition of growth rate" NARROW [] +is_a: GO:0040009 ! regulation of growth rate +is_a: GO:0045926 ! negative regulation of growth + +[Term] +id: GO:0045968 +name: negative regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "down-regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "downregulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "inhibition of juvenile hormone biosynthetic process" NARROW [] +synonym: "negative regulation of juvenile hormone anabolism" EXACT [] +synonym: "negative regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "negative regulation of juvenile hormone formation" EXACT [] +synonym: "negative regulation of juvenile hormone synthesis" EXACT [] +is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0045969 +name: positive regulation of juvenile hormone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone biosynthetic process" NARROW [] +synonym: "positive regulation of juvenile hormone anabolism" EXACT [] +synonym: "positive regulation of juvenile hormone biosynthesis" EXACT [] +synonym: "positive regulation of juvenile hormone formation" EXACT [] +synonym: "positive regulation of juvenile hormone synthesis" EXACT [] +synonym: "stimulation of juvenile hormone biosynthetic process" NARROW [] +synonym: "up regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "up-regulation of juvenile hormone biosynthetic process" EXACT [] +synonym: "upregulation of juvenile hormone biosynthetic process" EXACT [] +is_a: GO:0007557 ! regulation of juvenile hormone biosynthetic process +is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0006718 ! juvenile hormone biosynthetic process + +[Term] +id: GO:0045970 +name: negative regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone catabolic process" EXACT [] +synonym: "down-regulation of juvenile hormone catabolic process" EXACT [] +synonym: "downregulation of juvenile hormone catabolic process" EXACT [] +synonym: "inhibition of juvenile hormone catabolic process" NARROW [] +synonym: "negative regulation of juvenile hormone breakdown" EXACT [] +synonym: "negative regulation of juvenile hormone catabolism" EXACT [] +synonym: "negative regulation of juvenile hormone degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045928 ! negative regulation of juvenile hormone metabolic process +is_a: GO:0045952 ! regulation of juvenile hormone catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +relationship: negatively_regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045971 +name: positive regulation of juvenile hormone catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone catabolic process" NARROW [] +synonym: "positive regulation of juvenile hormone breakdown" EXACT [] +synonym: "positive regulation of juvenile hormone catabolism" EXACT [] +synonym: "positive regulation of juvenile hormone degradation" EXACT [] +synonym: "stimulation of juvenile hormone catabolic process" NARROW [] +synonym: "up regulation of juvenile hormone catabolic process" EXACT [] +synonym: "up-regulation of juvenile hormone catabolic process" EXACT [] +synonym: "upregulation of juvenile hormone catabolic process" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045929 ! positive regulation of juvenile hormone metabolic process +is_a: GO:0045952 ! regulation of juvenile hormone catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +relationship: positively_regulates GO:0006719 ! juvenile hormone catabolic process + +[Term] +id: GO:0045972 +name: negative regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] +synonym: "down regulation of juvenile hormone secretion" EXACT [] +synonym: "down-regulation of juvenile hormone secretion" EXACT [] +synonym: "downregulation of juvenile hormone secretion" EXACT [] +synonym: "inhibition of juvenile hormone secretion" NARROW [] +is_a: GO:0007558 ! regulation of juvenile hormone secretion +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0045973 +name: positive regulation of juvenile hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone." [GOC:go_curators] +synonym: "activation of juvenile hormone secretion" NARROW [] +synonym: "stimulation of juvenile hormone secretion" NARROW [] +synonym: "up regulation of juvenile hormone secretion" EXACT [] +synonym: "up-regulation of juvenile hormone secretion" EXACT [] +synonym: "upregulation of juvenile hormone secretion" EXACT [] +is_a: GO:0007558 ! regulation of juvenile hormone secretion +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +relationship: positively_regulates GO:0045443 ! juvenile hormone secretion + +[Term] +id: GO:0045974 +name: regulation of translation, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0045975 +name: positive regulation of translation, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of mRNA translation, ncRNA-mediated" NARROW [] +synonym: "stimulation of mRNA translation, ncRNA-mediated" NARROW [] +synonym: "up regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "up-regulation of mRNA translation, ncRNA-mediated" EXACT [] +synonym: "upregulation of mRNA translation, ncRNA-mediated" EXACT [] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0045974 ! regulation of translation, ncRNA-mediated + +[Term] +id: GO:0045976 +name: negative regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through embryonic mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through embryonic mitotic cell cycle" NARROW [] +synonym: "negative regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +relationship: negatively_regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0045977 +name: positive regulation of mitotic cell cycle, embryonic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progression through the embryonic mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of mitotic cell cycle, embryonic" NARROW [] +synonym: "positive regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of embryonic mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of mitotic cell cycle, embryonic" NARROW [] +synonym: "up regulation of mitotic cell cycle, embryonic" EXACT [] +synonym: "up-regulation of mitotic cell cycle, embryonic" EXACT [] +synonym: "upregulation of mitotic cell cycle, embryonic" EXACT [] +is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +relationship: positively_regulates GO:0045448 ! mitotic cell cycle, embryonic + +[Term] +id: GO:0045978 +name: negative regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +synonym: "down regulation of nucleoside metabolic process" EXACT [] +synonym: "down-regulation of nucleoside metabolic process" EXACT [] +synonym: "downregulation of nucleoside metabolic process" EXACT [] +synonym: "inhibition of nucleoside metabolic process" NARROW [] +synonym: "negative regulation of nucleoside metabolism" EXACT [] +is_a: GO:0009118 ! regulation of nucleoside metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0045979 +name: positive regulation of nucleoside metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] +synonym: "activation of nucleoside metabolic process" NARROW [] +synonym: "positive regulation of nucleoside metabolism" EXACT [] +synonym: "stimulation of nucleoside metabolic process" NARROW [] +synonym: "up regulation of nucleoside metabolic process" EXACT [] +synonym: "up-regulation of nucleoside metabolic process" EXACT [] +synonym: "upregulation of nucleoside metabolic process" EXACT [] +is_a: GO:0009118 ! regulation of nucleoside metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0009116 ! nucleoside metabolic process + +[Term] +id: GO:0045980 +name: negative regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +synonym: "down regulation of nucleotide metabolic process" EXACT [] +synonym: "down-regulation of nucleotide metabolic process" EXACT [] +synonym: "downregulation of nucleotide metabolic process" EXACT [] +synonym: "inhibition of nucleotide metabolic process" NARROW [] +synonym: "negative regulation of nucleotide metabolism" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0045981 +name: positive regulation of nucleotide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] +synonym: "activation of nucleotide metabolic process" NARROW [] +synonym: "positive regulation of nucleotide metabolism" EXACT [] +synonym: "stimulation of nucleotide metabolic process" NARROW [] +synonym: "up regulation of nucleotide metabolic process" EXACT [] +synonym: "up-regulation of nucleotide metabolic process" EXACT [] +synonym: "upregulation of nucleotide metabolic process" EXACT [] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0045982 +name: negative regulation of purine nucleobase metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases." [GOC:go_curators] +synonym: "down regulation of purine base metabolic process" EXACT [] +synonym: "down-regulation of purine base metabolic process" EXACT [] +synonym: "downregulation of purine base metabolic process" EXACT [] +synonym: "inhibition of purine base metabolic process" NARROW [] +synonym: "negative regulation of purine base metabolic process" EXACT [GOC:go_curators] +synonym: "negative regulation of purine base metabolism" EXACT [] +is_a: GO:0006141 ! regulation of purine nucleobase metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0045983 +name: positive regulation of purine nucleobase metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases." [GOC:go_curators] +synonym: "activation of purine base metabolic process" NARROW [] +synonym: "positive regulation of purine base metabolic process" EXACT [] +synonym: "positive regulation of purine base metabolism" EXACT [] +synonym: "stimulation of purine base metabolic process" NARROW [] +synonym: "up regulation of purine base metabolic process" EXACT [] +synonym: "up-regulation of purine base metabolic process" EXACT [] +synonym: "upregulation of purine base metabolic process" EXACT [] +is_a: GO:0006141 ! regulation of purine nucleobase metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0045984 +name: negative regulation of pyrimidine nucleobase metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] +synonym: "down regulation of pyrimidine base metabolic process" EXACT [] +synonym: "down-regulation of pyrimidine base metabolic process" EXACT [] +synonym: "downregulation of pyrimidine base metabolic process" EXACT [] +synonym: "inhibition of pyrimidine base metabolic process" NARROW [] +synonym: "negative regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] +synonym: "negative regulation of pyrimidine base metabolism" EXACT [] +is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0045985 +name: positive regulation of pyrimidine nucleobase metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] +synonym: "activation of pyrimidine base metabolic process" NARROW [] +synonym: "positive regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] +synonym: "positive regulation of pyrimidine base metabolism" EXACT [] +synonym: "stimulation of pyrimidine base metabolic process" NARROW [] +synonym: "up regulation of pyrimidine base metabolic process" EXACT [] +synonym: "up-regulation of pyrimidine base metabolic process" EXACT [] +synonym: "upregulation of pyrimidine base metabolic process" EXACT [] +is_a: GO:0006142 ! regulation of pyrimidine nucleobase metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006206 ! pyrimidine nucleobase metabolic process + +[Term] +id: GO:0045986 +name: negative regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +synonym: "down regulation of smooth muscle contraction" EXACT [] +synonym: "down-regulation of smooth muscle contraction" EXACT [] +synonym: "downregulation of smooth muscle contraction" EXACT [] +synonym: "inhibition of smooth muscle contraction" NARROW [] +synonym: "smooth muscle relaxation" RELATED [] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0045932 ! negative regulation of muscle contraction +relationship: negatively_regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0045987 +name: positive regulation of smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] +synonym: "activation of smooth muscle contraction" NARROW [] +synonym: "stimulation of smooth muscle contraction" NARROW [] +synonym: "up regulation of smooth muscle contraction" EXACT [] +synonym: "up-regulation of smooth muscle contraction" EXACT [] +synonym: "upregulation of smooth muscle contraction" EXACT [] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0045933 ! positive regulation of muscle contraction +relationship: positively_regulates GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0045988 +name: negative regulation of striated muscle contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +synonym: "down regulation of striated muscle contraction" EXACT [] +synonym: "down-regulation of striated muscle contraction" EXACT [] +synonym: "downregulation of striated muscle contraction" EXACT [] +synonym: "inhibition of striated muscle contraction" NARROW [] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0045932 ! negative regulation of muscle contraction +relationship: negatively_regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0045989 +name: positive regulation of striated muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] +synonym: "activation of striated muscle contraction" NARROW [] +synonym: "stimulation of striated muscle contraction" NARROW [] +synonym: "up regulation of striated muscle contraction" EXACT [] +synonym: "up-regulation of striated muscle contraction" EXACT [] +synonym: "upregulation of striated muscle contraction" EXACT [] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0045933 ! positive regulation of muscle contraction +relationship: positively_regulates GO:0006941 ! striated muscle contraction + +[Term] +id: GO:0045990 +name: carbon catabolite regulation of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445] +synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0031670 ! cellular response to nutrient + +[Term] +id: GO:0045991 +name: carbon catabolite activation of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:mah, PMID:10559153] +synonym: "positive regulation of transcription by carbon catabolites" EXACT [GOC:mah] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:0045990 ! carbon catabolite regulation of transcription + +[Term] +id: GO:0045992 +name: negative regulation of embryonic development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development." [GOC:go_curators] +synonym: "down regulation of embryonic development" EXACT [] +synonym: "down-regulation of embryonic development" EXACT [] +synonym: "downregulation of embryonic development" EXACT [] +synonym: "inhibition of embryonic development" NARROW [] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0009790 ! embryo development + +[Term] +id: GO:0045993 +name: negative regulation of translational initiation by iron +namespace: biological_process +def: "Any process involving iron that stops, prevents or reduces the rate of translational initiation." [GOC:go_curators] +synonym: "down regulation of translational initiation by iron" EXACT [] +synonym: "down-regulation of translational initiation by iron" EXACT [] +synonym: "downregulation of translational initiation by iron" EXACT [] +synonym: "inhibition of translational initiation by iron" NARROW [] +is_a: GO:0006447 ! regulation of translational initiation by iron +is_a: GO:0045947 ! negative regulation of translational initiation + +[Term] +id: GO:0045994 +name: positive regulation of translational initiation by iron +namespace: biological_process +def: "Any process involving iron that activates or increases the rate of translational initiation." [GOC:go_curators] +synonym: "activation of translational initiation by iron" NARROW [] +synonym: "stimulation of translational initiation by iron" NARROW [] +synonym: "up regulation of translational initiation by iron" EXACT [] +synonym: "up-regulation of translational initiation by iron" EXACT [] +synonym: "upregulation of translational initiation by iron" EXACT [] +is_a: GO:0006447 ! regulation of translational initiation by iron +is_a: GO:0045948 ! positive regulation of translational initiation + +[Term] +id: GO:0045995 +name: regulation of embryonic development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryonic development." [GOC:go_curators] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0009790 ! embryo development + +[Term] +id: GO:0045996 +name: negative regulation of transcription by pheromones +namespace: biological_process +def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription." [GOC:go_curators] +synonym: "down regulation of transcription by pheromones" EXACT [] +synonym: "down-regulation of transcription by pheromones" EXACT [] +synonym: "downregulation of transcription by pheromones" EXACT [] +synonym: "inhibition of transcription by pheromones" NARROW [] +is_a: GO:0009373 ! regulation of transcription by pheromones +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0045997 +name: negative regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "down regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "down-regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "downregulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "inhibition of ecdysteroid biosynthetic process" NARROW [] +synonym: "negative regulation of ecdysteroid anabolism" EXACT [] +synonym: "negative regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "negative regulation of ecdysteroid formation" EXACT [] +synonym: "negative regulation of ecdysteroid synthesis" EXACT [] +is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process +is_a: GO:0045965 ! negative regulation of ecdysteroid metabolic process +is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process +relationship: negatively_regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0045998 +name: positive regulation of ecdysteroid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] +synonym: "activation of ecdysteroid biosynthetic process" NARROW [] +synonym: "positive regulation of ecdysteroid anabolism" EXACT [] +synonym: "positive regulation of ecdysteroid biosynthesis" EXACT [] +synonym: "positive regulation of ecdysteroid formation" EXACT [] +synonym: "positive regulation of ecdysteroid synthesis" EXACT [] +synonym: "stimulation of ecdysteroid biosynthetic process" NARROW [] +synonym: "up regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "up-regulation of ecdysteroid biosynthetic process" EXACT [] +synonym: "upregulation of ecdysteroid biosynthetic process" EXACT [] +is_a: GO:0007554 ! regulation of ecdysteroid biosynthetic process +is_a: GO:0045966 ! positive regulation of ecdysteroid metabolic process +is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process +relationship: positively_regulates GO:0045456 ! ecdysteroid biosynthetic process + +[Term] +id: GO:0045999 +name: negative regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] +synonym: "down regulation of ecdysteroid secretion" EXACT [] +synonym: "down-regulation of ecdysteroid secretion" EXACT [] +synonym: "downregulation of ecdysteroid secretion" EXACT [] +synonym: "inhibition of ecdysteroid secretion" NARROW [] +is_a: GO:0007555 ! regulation of ecdysteroid secretion +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +relationship: negatively_regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0046000 +name: positive regulation of ecdysteroid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of ecdysteroid." [GOC:go_curators] +synonym: "activation of ecdysteroid secretion" NARROW [] +synonym: "stimulation of ecdysteroid secretion" NARROW [] +synonym: "up regulation of ecdysteroid secretion" EXACT [] +synonym: "up-regulation of ecdysteroid secretion" EXACT [] +synonym: "upregulation of ecdysteroid secretion" EXACT [] +is_a: GO:0007555 ! regulation of ecdysteroid secretion +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +relationship: positively_regulates GO:0045457 ! ecdysteroid secretion + +[Term] +id: GO:0046001 +name: negative regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "negative regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle +is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic +relationship: negatively_regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0046002 +name: positive regulation of preblastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "positive regulation of preblastoderm mitotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through preblastoderm mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through preblastoderm mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through preblastoderm mitotic cell cycle" EXACT [] +is_a: GO:0007347 ! regulation of preblastoderm mitotic cell cycle +is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic +relationship: positively_regulates GO:0035185 ! preblastoderm mitotic cell cycle + +[Term] +id: GO:0046003 +name: negative regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "down regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "down-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "downregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "inhibition of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "negative regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of syncytial blastoderm cell cycle progression" EXACT [] +is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle +is_a: GO:0045976 ! negative regulation of mitotic cell cycle, embryonic +relationship: negatively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0046004 +name: positive regulation of syncytial blastoderm mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] +synonym: "activation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "positive regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of syncytial blastoderm cell cycle progression" EXACT [] +synonym: "stimulation of progression through syncytial blastoderm mitotic cell cycle" NARROW [] +synonym: "up regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "up-regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +synonym: "upregulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [] +is_a: GO:0007348 ! regulation of syncytial blastoderm mitotic cell cycle +is_a: GO:0045977 ! positive regulation of mitotic cell cycle, embryonic +relationship: positively_regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle + +[Term] +id: GO:0046005 +name: positive regulation of circadian sleep/wake cycle, REM sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "positive regulation of REM sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, REM sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, REM sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, REM sleep" EXACT [] +is_a: GO:0042320 ! regulation of circadian sleep/wake cycle, REM sleep +is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep +relationship: positively_regulates GO:0042747 ! circadian sleep/wake cycle, REM sleep + +[Term] +id: GO:0046006 +name: regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activated T cell proliferation." [GOC:go_curators] +synonym: "regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "regulation of activated T-cell proliferation" EXACT [] +synonym: "regulation of activated T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0046007 +name: negative regulation of activated T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of activated T cell proliferation." [GOC:go_curators] +synonym: "down regulation of activated T cell proliferation" EXACT [] +synonym: "down-regulation of activated T cell proliferation" EXACT [] +synonym: "downregulation of activated T cell proliferation" EXACT [] +synonym: "inhibition of activated T cell proliferation" NARROW [] +synonym: "negative regulation of activated T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of activated T-cell proliferation" EXACT [] +synonym: "negative regulation of activated T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046006 ! regulation of activated T cell proliferation +relationship: negatively_regulates GO:0050798 ! activated T cell proliferation + +[Term] +id: GO:0046008 +name: regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that modulates the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] +is_a: GO:0045924 ! regulation of female receptivity + +[Term] +id: GO:0046009 +name: positive regulation of female receptivity, post-mating +namespace: biological_process +def: "Any process that increases the receptiveness of a female to male advances subsequent to mating." [GOC:go_curators] +synonym: "activation of female receptivity, post-mating" NARROW [] +synonym: "stimulation of female receptivity, post-mating" NARROW [] +synonym: "up regulation of female receptivity, post-mating" EXACT [] +synonym: "up-regulation of female receptivity, post-mating" EXACT [] +synonym: "upregulation of female receptivity, post-mating" EXACT [] +is_a: GO:0045925 ! positive regulation of female receptivity +is_a: GO:0046008 ! regulation of female receptivity, post-mating + +[Term] +id: GO:0046010 +name: positive regulation of circadian sleep/wake cycle, non-REM sleep +namespace: biological_process +def: "Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:go_curators] +synonym: "activation of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "positive regulation of non-REM sleep" EXACT [] +synonym: "stimulation of circadian sleep/wake cycle, non-REM sleep" NARROW [] +synonym: "up regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "up-regulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +synonym: "upregulation of circadian sleep/wake cycle, non-REM sleep" EXACT [] +is_a: GO:0045188 ! regulation of circadian sleep/wake cycle, non-REM sleep +is_a: GO:0045938 ! positive regulation of circadian sleep/wake cycle, sleep +relationship: positively_regulates GO:0042748 ! circadian sleep/wake cycle, non-REM sleep + +[Term] +id: GO:0046011 +name: regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex." [GOC:go_curators, PMID:12538512] +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0046012 +name: positive regulation of oskar mRNA translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oskar mRNA translation." [GOC:go_curators] +synonym: "activation of oskar mRNA translation" NARROW [] +synonym: "stimulation of oskar mRNA translation" NARROW [] +synonym: "up regulation of oskar mRNA translation" EXACT [] +synonym: "up-regulation of oskar mRNA translation" EXACT [] +synonym: "upregulation of oskar mRNA translation" EXACT [] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0046011 ! regulation of oskar mRNA translation + +[Term] +id: GO:0046013 +name: regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of resting T cell proliferation." [GOC:go_curators] +synonym: "regulation of resting T cell proliferation" EXACT [] +synonym: "regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "regulation of T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +relationship: regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0046014 +name: negative regulation of T cell homeostatic proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation." [GOC:go_curators] +synonym: "down regulation of T cell homeostatic proliferation" EXACT [] +synonym: "down-regulation of T cell homeostatic proliferation" EXACT [] +synonym: "downregulation of T cell homeostatic proliferation" EXACT [] +synonym: "inhibition of T cell homeostatic proliferation" NARROW [] +synonym: "negative regulation of resting T cell proliferation" EXACT [] +synonym: "negative regulation of T lymphocyte homeostatic proliferation" EXACT [] +synonym: "negative regulation of T-cell homeostatic proliferation" EXACT [] +synonym: "negative regulation of T-lymphocyte homeostatic proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046013 ! regulation of T cell homeostatic proliferation +relationship: negatively_regulates GO:0001777 ! T cell homeostatic proliferation + +[Term] +id: GO:0046015 +name: regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] +is_a: GO:0006355 ! regulation of transcription, DNA-templated + +[Term] +id: GO:0046016 +name: positive regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that activates or increases the rate of transcription." [GOC:go_curators] +synonym: "activation of transcription by glucose" NARROW [] +synonym: "stimulation of transcription by glucose" NARROW [] +synonym: "up regulation of transcription by glucose" EXACT [] +synonym: "up-regulation of transcription by glucose" EXACT [] +synonym: "upregulation of transcription by glucose" EXACT [] +is_a: GO:0045991 ! carbon catabolite activation of transcription +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0046017 +name: obsolete regulation of transcription from RNA polymerase I promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "mitotic regulation of transcription from Pol I promoter" EXACT [] +synonym: "regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0006356 +consider: GO:0044772 + +[Term] +id: GO:0046018 +name: obsolete positive regulation of transcription from RNA polymerase I promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "activation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic activation of transcription from Pol I promoter" EXACT [] +synonym: "positive regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] +synonym: "positive regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] +synonym: "stimulation of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] +synonym: "up regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +synonym: "up-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +synonym: "upregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0044772 +consider: GO:0045943 + +[Term] +id: GO:0046019 +name: regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] +synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0009373 ! regulation of transcription by pheromones + +[Term] +id: GO:0046020 +name: negative regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] +synonym: "down regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter by pheromones" NARROW [] +synonym: "negative regulation of transcription from Pol II promoter by pheromones" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0045996 ! negative regulation of transcription by pheromones +is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones + +[Term] +id: GO:0046021 +name: obsolete regulation of transcription from RNA polymerase II promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "mitotic regulation of transcription from Pol II promoter" EXACT [] +synonym: "regulation of transcription from Pol II promoter, mitotic" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0006357 +consider: GO:0044772 + +[Term] +id: GO:0046022 +name: obsolete positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "activation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic activation of transcription from Pol II promoter" EXACT [] +synonym: "positive regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] +synonym: "positive regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] +synonym: "stimulation of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] +synonym: "up regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +synonym: "up-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +synonym: "upregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0044772 +consider: GO:0045944 + +[Term] +id: GO:0046023 +name: obsolete regulation of transcription from RNA polymerase III promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "mitotic regulation of transcription from Pol III promoter" EXACT [] +synonym: "regulation of transcription from Pol III promoter, mitotic" EXACT [] +synonym: "regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0006359 +consider: GO:0044772 + +[Term] +id: GO:0046024 +name: obsolete positive regulation of transcription from RNA polymerase III promoter during mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase III that occurs during the mitotic cell cycle." [GOC:go_curators] +comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. +synonym: "activation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] +synonym: "mitotic activation of transcription from Pol III promoter" EXACT [] +synonym: "positive regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] +synonym: "positive regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] +synonym: "stimulation of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] +synonym: "up regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +synonym: "up-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +synonym: "upregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0044772 +consider: GO:0045945 + +[Term] +id: GO:0046025 +name: precorrin-6Y C5,15-methyltransferase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2." [EC:2.1.1.132] +synonym: "precorrin-6 methyltransferase activity" BROAD [EC:2.1.1.132] +synonym: "precorrin-6Y methylase activity" BROAD [EC:2.1.1.132] +synonym: "S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)" RELATED [EC:2.1.1.132] +xref: EC:2.1.1.132 +xref: MetaCyc:2.1.1.132-RXN +xref: RHEA:17477 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046026 +name: precorrin-4 C11-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." [EC:2.1.1.133] +synonym: "CobM" RELATED [EC:2.1.1.133] +synonym: "S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity" RELATED [EC:2.1.1.133] +xref: EC:2.1.1.133 +xref: MetaCyc:2.1.1.133-RXN +xref: RHEA:22012 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046027 +name: phospholipid:diacylglycerol acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] +synonym: "PDAT activity" RELATED [EC:2.3.1.158] +synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" RELATED [EC:2.3.1.158] +xref: EC:2.3.1.158 +xref: MetaCyc:2.3.1.158-RXN +xref: RHEA:14057 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0046028 +name: electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity +namespace: molecular_function +def: "Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363] +synonym: "plastocyanin" NARROW [] +is_a: GO:0009055 ! electron transfer activity + +[Term] +id: GO:0046029 +name: mannitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." [EC:1.1.1.255, RHEA:15029] +synonym: "mannitol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.255] +synonym: "MTD activity" RELATED [EC:1.1.1.255] +synonym: "NAD-dependent mannitol dehydrogenase activity" BROAD [EC:1.1.1.255] +xref: EC:1.1.1.255 +xref: KEGG_REACTION:R07135 +xref: MetaCyc:1.1.1.255-RXN +xref: RHEA:15029 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0046030 +name: inositol trisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate." [GOC:bf] +synonym: "inositol-1,4,5-trisphosphate phosphatase" NARROW [] +synonym: "IP(3) phosphatase activity" EXACT [] +synonym: "IP3 phosphatase activity" EXACT [] +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0046031 +name: ADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate." [GOC:go_curators] +synonym: "ADP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046032 +name: ADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate." [GOC:go_curators] +synonym: "ADP breakdown" EXACT [] +synonym: "ADP catabolism" EXACT [] +synonym: "ADP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046031 ! ADP metabolic process + +[Term] +id: GO:0046033 +name: AMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving AMP, adenosine monophosphate." [GOC:go_curators] +synonym: "adenylate forming enzyme activity" RELATED [] +synonym: "AMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046034 +name: ATP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] +synonym: "ATP metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0046035 +name: CMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP, cytidine monophosphate." [GOC:go_curators] +synonym: "CMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046036 +name: CTP metabolic process +namespace: biological_process +alt_id: GO:0006243 +def: "The chemical reactions and pathways involving CTP, cytidine triphosphate." [GOC:go_curators] +synonym: "CTP deamination" NARROW [] +synonym: "CTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046037 +name: GMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GMP, guanosine monophosphate." [GOC:go_curators] +synonym: "GMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046038 +name: GMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of GMP, guanosine monophosphate." [GOC:go_curators] +synonym: "GMP breakdown" EXACT [] +synonym: "GMP catabolism" EXACT [] +synonym: "GMP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process +is_a: GO:0046037 ! GMP metabolic process + +[Term] +id: GO:0046039 +name: GTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GTP, guanosine triphosphate." [GOC:go_curators] +synonym: "GTP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046040 +name: IMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving IMP, inosine monophosphate." [GOC:go_curators] +synonym: "IMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046041 +name: ITP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ITP, inosine triphosphate." [GOC:go_curators] +synonym: "ITP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046042 +name: ITP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ITP, inosine triphosphate." [GOC:go_curators] +synonym: "ITP anabolism" EXACT [] +synonym: "ITP biosynthesis" EXACT [] +synonym: "ITP formation" EXACT [] +synonym: "ITP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process +is_a: GO:0046041 ! ITP metabolic process + +[Term] +id: GO:0046043 +name: TDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TDP, ribosylthymine diphosphate." [GOC:go_curators] +synonym: "TDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046044 +name: TMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TMP, ribosylthymine monophosphate." [GOC:go_curators] +synonym: "TMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046045 +name: TMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TMP, ribosylthymine monophosphate." [GOC:go_curators] +synonym: "TMP breakdown" EXACT [] +synonym: "TMP catabolism" EXACT [] +synonym: "TMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046044 ! TMP metabolic process + +[Term] +id: GO:0046046 +name: TTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving TTP, ribosylthymine triphosphate." [GOC:go_curators] +synonym: "TTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046047 +name: TTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of TTP, ribosylthymine triphosphate." [GOC:go_curators] +synonym: "TTP breakdown" EXACT [] +synonym: "TTP catabolism" EXACT [] +synonym: "TTP degradation" EXACT [] +synonym: "TTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046046 ! TTP metabolic process + +[Term] +id: GO:0046048 +name: UDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP, uridine (5'-)diphosphate." [GOC:go_curators] +synonym: "UDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046049 +name: UMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UMP, uridine monophosphate." [GOC:go_curators] +synonym: "UMP metabolism" EXACT [] +is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046050 +name: UMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UMP, uridine monophosphate." [GOC:go_curators] +synonym: "UMP breakdown" EXACT [] +synonym: "UMP catabolism" EXACT [] +synonym: "UMP degradation" EXACT [] +is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046049 ! UMP metabolic process + +[Term] +id: GO:0046051 +name: UTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UTP, uridine (5'-)triphosphate." [GOC:go_curators] +synonym: "UTP metabolism" EXACT [] +is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046052 +name: UTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of UTP, uridine (5'-)triphosphate." [GOC:go_curators] +synonym: "UTP breakdown" EXACT [] +synonym: "UTP catabolism" EXACT [] +synonym: "UTP degradation" EXACT [] +synonym: "UTP hydrolysis" EXACT [] +is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046051 ! UTP metabolic process + +[Term] +id: GO:0046053 +name: dAMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] +synonym: "dAMP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046054 +name: dGMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] +synonym: "dGMP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process + +[Term] +id: GO:0046055 +name: dGMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [GOC:go_curators] +synonym: "dGMP breakdown" EXACT [] +synonym: "dGMP catabolism" EXACT [] +synonym: "dGMP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046054 ! dGMP metabolic process + +[Term] +id: GO:0046056 +name: dADP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] +synonym: "dADP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046057 +name: dADP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [GOC:go_curators] +synonym: "dADP breakdown" EXACT [] +synonym: "dADP catabolism" EXACT [] +synonym: "dADP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046056 ! dADP metabolic process + +[Term] +id: GO:0046058 +name: cAMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators] +synonym: "3',5' cAMP metabolic process" EXACT [] +synonym: "3',5' cAMP metabolism" EXACT [] +synonym: "3',5'-cAMP metabolic process" EXACT [] +synonym: "3',5'-cAMP metabolism" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT [] +synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT [] +synonym: "cAMP generating peptide activity" RELATED [] +synonym: "cAMP metabolism" EXACT [] +synonym: "cyclic AMP metabolic process" EXACT [] +synonym: "cyclic AMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0046059 +name: dAMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [GOC:go_curators] +synonym: "dAMP breakdown" EXACT [] +synonym: "dAMP catabolism" EXACT [] +synonym: "dAMP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009172 ! purine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0046053 ! dAMP metabolic process + +[Term] +id: GO:0046060 +name: dATP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] +synonym: "dATP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046061 +name: dATP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [GOC:go_curators] +synonym: "dATP breakdown" EXACT [] +synonym: "dATP catabolism" EXACT [] +synonym: "dATP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0046060 ! dATP metabolic process + +[Term] +id: GO:0046062 +name: dCDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCDP, deoxycytidine 5'-diphosphate." [GOC:go_curators] +synonym: "dCDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046063 +name: dCMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCMP, deoxycytidine monophosphate." [GOC:go_curators] +synonym: "dCMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046064 +name: dCMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate." [GOC:go_curators] +synonym: "dCMP anabolism" EXACT [] +synonym: "dCMP biosynthesis" EXACT [] +synonym: "dCMP formation" EXACT [] +synonym: "dCMP synthesis" EXACT [] +is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process +is_a: GO:0046063 ! dCMP metabolic process + +[Term] +id: GO:0046065 +name: dCTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dCTP, deoxycytidine triphosphate." [GOC:go_curators] +synonym: "dCTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046066 +name: dGDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] +synonym: "dGDP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046067 +name: dGDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [GOC:go_curators] +synonym: "dGDP breakdown" EXACT [] +synonym: "dGDP catabolism" EXACT [] +synonym: "dGDP degradation" EXACT [] +is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process +is_a: GO:0009184 ! purine deoxyribonucleoside diphosphate catabolic process +is_a: GO:0046066 ! dGDP metabolic process + +[Term] +id: GO:0046068 +name: cGMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] +synonym: "cGMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009187 ! cyclic nucleotide metabolic process + +[Term] +id: GO:0046069 +name: cGMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cyclic GMP, guanosine 3',5'-phosphate." [GOC:go_curators] +synonym: "cGMP breakdown" EXACT [] +synonym: "cGMP catabolism" EXACT [] +synonym: "cGMP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009214 ! cyclic nucleotide catabolic process +is_a: GO:0046068 ! cGMP metabolic process + +[Term] +id: GO:0046070 +name: dGTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dGTP, guanosine triphosphate." [GOC:go_curators] +synonym: "dGTP metabolism" EXACT [] +is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process +is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process + +[Term] +id: GO:0046071 +name: dGTP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dGTP, guanosine triphosphate." [GOC:go_curators] +synonym: "dGTP anabolism" EXACT [] +synonym: "dGTP biosynthesis" EXACT [] +synonym: "dGTP formation" EXACT [] +synonym: "dGTP synthesis" EXACT [] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process +is_a: GO:0046070 ! dGTP metabolic process + +[Term] +id: GO:0046072 +name: dTDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP, deoxyribosylthymine diphosphate." [GOC:go_curators] +synonym: "dTDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046073 +name: dTMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [GOC:go_curators] +synonym: "dTMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046074 +name: dTMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTMP, deoxyribosylthymine monophosphate." [GOC:go_curators] +synonym: "dTMP breakdown" EXACT [] +synonym: "dTMP catabolism" EXACT [] +synonym: "dTMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046073 ! dTMP metabolic process + +[Term] +id: GO:0046075 +name: dTTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] +synonym: "dTTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046076 +name: dTTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] +synonym: "dTTP breakdown" EXACT [] +synonym: "dTTP catabolism" EXACT [] +synonym: "dTTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046075 ! dTTP metabolic process + +[Term] +id: GO:0046077 +name: dUDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUDP, deoxyuridine (5'-)diphosphate." [GOC:go_curators] +synonym: "dUDP metabolism" EXACT [] +is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046078 +name: dUMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUMP, deoxyuridine (5'-)monophosphate (2'-deoxyuridine 5'-phosphate)." [GOC:go_curators] +synonym: "dUMP metabolism" EXACT [] +is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046079 +name: dUMP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUMP, deoxyuridine (5'-)monophosphate." [GOC:go_curators] +synonym: "dUMP breakdown" EXACT [] +synonym: "dUMP catabolism" EXACT [] +synonym: "dUMP degradation" EXACT [] +is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046078 ! dUMP metabolic process + +[Term] +id: GO:0046080 +name: dUTP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] +synonym: "dUTP metabolism" EXACT [] +is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process +is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process + +[Term] +id: GO:0046081 +name: dUTP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dUTP, deoxyuridine (5'-)triphosphate." [GOC:go_curators] +synonym: "dUTP breakdown" EXACT [] +synonym: "dUTP catabolism" EXACT [] +synonym: "dUTP degradation" EXACT [] +is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process +is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process +is_a: GO:0046080 ! dUTP metabolic process + +[Term] +id: GO:0046082 +name: 5-methylcytosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] +synonym: "5-methylcytosine anabolism" EXACT [] +synonym: "5-methylcytosine biosynthesis" EXACT [] +synonym: "5-methylcytosine formation" EXACT [] +synonym: "5-methylcytosine synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019857 ! 5-methylcytosine metabolic process +is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process + +[Term] +id: GO:0046083 +name: adenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] +synonym: "adenine metabolism" EXACT [] +is_a: GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0046084 +name: adenine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [GOC:go_curators] +synonym: "adenine anabolism" EXACT [] +synonym: "adenine biosynthesis" EXACT [] +synonym: "adenine formation" EXACT [] +synonym: "adenine synthesis" EXACT [] +is_a: GO:0009113 ! purine nucleobase biosynthetic process +is_a: GO:0046083 ! adenine metabolic process + +[Term] +id: GO:0046085 +name: adenosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +synonym: "adenosine metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046086 +name: adenosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] +synonym: "adenosine anabolism" EXACT [] +synonym: "adenosine biosynthesis" EXACT [] +synonym: "adenosine formation" EXACT [] +synonym: "adenosine synthesis" EXACT [] +is_a: GO:0046085 ! adenosine metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0046087 +name: cytidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] +synonym: "cytidine metabolism" EXACT [] +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process + +[Term] +id: GO:0046088 +name: cytidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:go_curators] +synonym: "cytidine anabolism" EXACT [] +synonym: "cytidine biosynthesis" EXACT [] +synonym: "cytidine formation" EXACT [] +synonym: "cytidine synthesis" EXACT [] +is_a: GO:0046087 ! cytidine metabolic process +is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process + +[Term] +id: GO:0046089 +name: cytosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] +synonym: "cytosine anabolism" EXACT [] +synonym: "cytosine biosynthesis" EXACT [] +synonym: "cytosine formation" EXACT [] +synonym: "cytosine synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process +is_a: GO:0019858 ! cytosine metabolic process + +[Term] +id: GO:0046090 +name: deoxyadenosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyadenosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046091 +name: deoxyadenosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyadenosine anabolism" EXACT [] +synonym: "deoxyadenosine biosynthesis" EXACT [] +synonym: "deoxyadenosine formation" EXACT [] +synonym: "deoxyadenosine synthesis" EXACT [] +is_a: GO:0046090 ! deoxyadenosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046092 +name: deoxycytidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxycytidine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046093 +name: deoxycytidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxycytidine anabolism" EXACT [] +synonym: "deoxycytidine biosynthesis" EXACT [] +synonym: "deoxycytidine formation" EXACT [] +synonym: "deoxycytidine synthesis" EXACT [] +is_a: GO:0046092 ! deoxycytidine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046094 +name: deoxyinosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +synonym: "deoxyinosine metabolism" EXACT [] +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046095 +name: deoxyinosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] +synonym: "deoxyinosine anabolism" EXACT [] +synonym: "deoxyinosine biosynthesis" EXACT [] +synonym: "deoxyinosine formation" EXACT [] +synonym: "deoxyinosine synthesis" EXACT [] +is_a: GO:0046094 ! deoxyinosine metabolic process +is_a: GO:0046123 ! purine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046096 +name: deoxyuridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyuridine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046097 +name: deoxyuridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] +synonym: "deoxyuridine anabolism" EXACT [] +synonym: "deoxyuridine biosynthesis" EXACT [] +synonym: "deoxyuridine formation" EXACT [] +synonym: "deoxyuridine synthesis" EXACT [] +is_a: GO:0046096 ! deoxyuridine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046098 +name: guanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +synonym: "guanine metabolism" EXACT [] +is_a: GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0046099 +name: guanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] +synonym: "guanine anabolism" EXACT [] +synonym: "guanine biosynthesis" EXACT [] +synonym: "guanine formation" EXACT [] +synonym: "guanine synthesis" EXACT [] +is_a: GO:0009113 ! purine nucleobase biosynthetic process +is_a: GO:0046098 ! guanine metabolic process + +[Term] +id: GO:0046100 +name: hypoxanthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] +synonym: "hypoxanthine metabolism" EXACT [] +is_a: GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0046101 +name: hypoxanthine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] +synonym: "hypoxanthine anabolism" EXACT [] +synonym: "hypoxanthine biosynthesis" EXACT [] +synonym: "hypoxanthine formation" EXACT [] +synonym: "hypoxanthine synthesis" EXACT [] +is_a: GO:0009113 ! purine nucleobase biosynthetic process +is_a: GO:0046100 ! hypoxanthine metabolic process + +[Term] +id: GO:0046102 +name: inosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +synonym: "inosine metabolism" EXACT [] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046103 +name: inosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] +synonym: "inosine anabolism" EXACT [] +synonym: "inosine biosynthesis" EXACT [] +synonym: "inosine formation" EXACT [] +synonym: "inosine synthesis" EXACT [] +is_a: GO:0046102 ! inosine metabolic process +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process + +[Term] +id: GO:0046104 +name: thymidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +synonym: "deoxyribosylthymine metabolic process" EXACT [] +synonym: "deoxyribosylthymine metabolism" EXACT [] +synonym: "thymidine metabolism" EXACT [] +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046105 +name: thymidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] +synonym: "deoxyribosylthymine biosynthesis" EXACT [] +synonym: "deoxyribosylthymine biosynthetic process" EXACT [] +synonym: "thymidine anabolism" EXACT [] +synonym: "thymidine biosynthesis" EXACT [] +synonym: "thymidine formation" EXACT [] +synonym: "thymidine synthesis" EXACT [] +is_a: GO:0046104 ! thymidine metabolic process +is_a: GO:0046126 ! pyrimidine deoxyribonucleoside biosynthetic process + +[Term] +id: GO:0046106 +name: thymine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] +synonym: "thymine anabolism" EXACT [] +synonym: "thymine biosynthesis" EXACT [] +synonym: "thymine formation" EXACT [] +synonym: "thymine synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process +is_a: GO:0019859 ! thymine metabolic process + +[Term] +id: GO:0046107 +name: uracil biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] +synonym: "uracil anabolism" EXACT [] +synonym: "uracil biosynthesis" EXACT [] +synonym: "uracil formation" EXACT [] +synonym: "uracil synthesis" EXACT [] +is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process +is_a: GO:0019860 ! uracil metabolic process + +[Term] +id: GO:0046108 +name: uridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +synonym: "uridine metabolism" EXACT [] +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process + +[Term] +id: GO:0046109 +name: uridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] +synonym: "uridine anabolism" EXACT [] +synonym: "uridine biosynthesis" EXACT [] +synonym: "uridine formation" EXACT [] +synonym: "uridine synthesis" EXACT [] +is_a: GO:0046108 ! uridine metabolic process +is_a: GO:0046132 ! pyrimidine ribonucleoside biosynthetic process + +[Term] +id: GO:0046110 +name: xanthine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +synonym: "xanthine metabolism" EXACT [] +is_a: GO:0006144 ! purine nucleobase metabolic process + +[Term] +id: GO:0046111 +name: xanthine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] +synonym: "xanthine anabolism" EXACT [] +synonym: "xanthine biosynthesis" EXACT [] +synonym: "xanthine formation" EXACT [] +synonym: "xanthine synthesis" EXACT [] +is_a: GO:0009113 ! purine nucleobase biosynthetic process +is_a: GO:0046110 ! xanthine metabolic process + +[Term] +id: GO:0046112 +name: nucleobase biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] +synonym: "nucleobase anabolism" EXACT [] +synonym: "nucleobase biosynthesis" EXACT [] +synonym: "nucleobase formation" EXACT [] +synonym: "nucleobase synthesis" EXACT [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0046113 +name: nucleobase catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid." [GOC:ai] +synonym: "nucleobase breakdown" EXACT [] +synonym: "nucleobase catabolism" EXACT [] +synonym: "nucleobase degradation" EXACT [] +is_a: GO:0009112 ! nucleobase metabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0046114 +name: guanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] +synonym: "guanosine anabolism" EXACT [] +synonym: "guanosine biosynthesis" EXACT [] +synonym: "guanosine formation" EXACT [] +synonym: "guanosine synthesis" EXACT [] +is_a: GO:0008617 ! guanosine metabolic process +is_a: GO:1901070 ! guanosine-containing compound biosynthetic process + +[Term] +id: GO:0046115 +name: guanosine catabolic process +namespace: biological_process +alt_id: GO:0006160 +def: "The chemical reactions and pathways resulting in the breakdown of guanine, guanine riboside, a nucleoside with a wide species distribution." [GOC:go_curators] +synonym: "guanosine breakdown" EXACT [] +synonym: "guanosine catabolism" EXACT [] +synonym: "guanosine degradation" EXACT [] +synonym: "guanosine phosphorolysis" RELATED [] +is_a: GO:0008617 ! guanosine metabolic process +is_a: GO:1901069 ! guanosine-containing compound catabolic process + +[Term] +id: GO:0046116 +name: queuosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732] +synonym: "queuosine metabolism" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process + +[Term] +id: GO:0046117 +name: queuosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [ISBN:0198506732] +synonym: "queuosine breakdown" EXACT [] +synonym: "queuosine catabolism" EXACT [] +synonym: "queuosine degradation" EXACT [] +is_a: GO:0042454 ! ribonucleoside catabolic process +is_a: GO:0046116 ! queuosine metabolic process + +[Term] +id: GO:0046118 +name: 7-methylguanosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] +synonym: "7-methylguanosine anabolism" EXACT [] +synonym: "7-methylguanosine biosynthesis" EXACT [] +synonym: "7-methylguanosine formation" EXACT [] +synonym: "7-methylguanosine synthesis" EXACT [] +is_a: GO:0008618 ! 7-methylguanosine metabolic process +is_a: GO:1901070 ! guanosine-containing compound biosynthetic process + +[Term] +id: GO:0046119 +name: 7-methylguanosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] +synonym: "7-methylguanosine breakdown" EXACT [] +synonym: "7-methylguanosine catabolism" EXACT [] +synonym: "7-methylguanosine degradation" EXACT [] +is_a: GO:0008618 ! 7-methylguanosine metabolic process +is_a: GO:1901069 ! guanosine-containing compound catabolic process + +[Term] +id: GO:0046120 +name: deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "deoxyribonucleoside anabolism" EXACT [] +synonym: "deoxyribonucleoside biosynthesis" EXACT [] +synonym: "deoxyribonucleoside formation" EXACT [] +synonym: "deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process + +[Term] +id: GO:0046121 +name: deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "deoxyribonucleoside breakdown" EXACT [] +synonym: "deoxyribonucleoside catabolism" EXACT [] +synonym: "deoxyribonucleoside degradation" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process + +[Term] +id: GO:0046122 +name: purine deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "purine deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0009120 ! deoxyribonucleoside metabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0046123 +name: purine deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "purine deoxyribonucleoside anabolism" EXACT [] +synonym: "purine deoxyribonucleoside biosynthesis" EXACT [] +synonym: "purine deoxyribonucleoside formation" EXACT [] +synonym: "purine deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0042451 ! purine nucleoside biosynthetic process +is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046124 +name: purine deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "purine deoxyribonucleoside breakdown" EXACT [] +synonym: "purine deoxyribonucleoside catabolism" EXACT [] +synonym: "purine deoxyribonucleoside degradation" EXACT [] +is_a: GO:0006152 ! purine nucleoside catabolic process +is_a: GO:0046121 ! deoxyribonucleoside catabolic process +is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process + +[Term] +id: GO:0046125 +name: pyrimidine deoxyribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "pyrimidine deoxyribonucleoside metabolism" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009120 ! deoxyribonucleoside metabolic process + +[Term] +id: GO:0046126 +name: pyrimidine deoxyribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "pyrimidine deoxyribonucleoside anabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside biosynthesis" EXACT [] +synonym: "pyrimidine deoxyribonucleoside formation" EXACT [] +synonym: "pyrimidine deoxyribonucleoside synthesis" EXACT [] +is_a: GO:0046120 ! deoxyribonucleoside biosynthetic process +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process + +[Term] +id: GO:0046127 +name: pyrimidine deoxyribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "pyrimidine deoxyribonucleoside breakdown" EXACT [] +synonym: "pyrimidine deoxyribonucleoside catabolism" EXACT [] +synonym: "pyrimidine deoxyribonucleoside degradation" EXACT [] +is_a: GO:0046121 ! deoxyribonucleoside catabolic process +is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process +is_a: GO:0046135 ! pyrimidine nucleoside catabolic process + +[Term] +id: GO:0046128 +name: purine ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "purine ribonucleoside metabolism" EXACT [] +is_a: GO:0009119 ! ribonucleoside metabolic process +is_a: GO:0042278 ! purine nucleoside metabolic process + +[Term] +id: GO:0046129 +name: purine ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "purine ribonucleoside anabolism" EXACT [] +synonym: "purine ribonucleoside biosynthesis" EXACT [] +synonym: "purine ribonucleoside formation" EXACT [] +synonym: "purine ribonucleoside synthesis" EXACT [] +is_a: GO:0042451 ! purine nucleoside biosynthetic process +is_a: GO:0042455 ! ribonucleoside biosynthetic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046130 +name: purine ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "purine ribonucleoside breakdown" EXACT [] +synonym: "purine ribonucleoside catabolism" EXACT [] +synonym: "purine ribonucleoside degradation" EXACT [] +is_a: GO:0006152 ! purine nucleoside catabolic process +is_a: GO:0042454 ! ribonucleoside catabolic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046131 +name: pyrimidine ribonucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "pyrimidine ribonucleoside metabolism" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009119 ! ribonucleoside metabolic process + +[Term] +id: GO:0046132 +name: pyrimidine ribonucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "pyrimidine ribonucleoside anabolism" EXACT [] +synonym: "pyrimidine ribonucleoside biosynthesis" EXACT [] +synonym: "pyrimidine ribonucleoside formation" EXACT [] +synonym: "pyrimidine ribonucleoside synthesis" EXACT [] +is_a: GO:0042455 ! ribonucleoside biosynthetic process +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process + +[Term] +id: GO:0046133 +name: pyrimidine ribonucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which a pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] +synonym: "pyrimidine ribonucleoside breakdown" EXACT [] +synonym: "pyrimidine ribonucleoside catabolism" EXACT [] +synonym: "pyrimidine ribonucleoside degradation" EXACT [] +is_a: GO:0042454 ! ribonucleoside catabolic process +is_a: GO:0046131 ! pyrimidine ribonucleoside metabolic process +is_a: GO:0046135 ! pyrimidine nucleoside catabolic process + +[Term] +id: GO:0046134 +name: pyrimidine nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "pyrimidine nucleoside anabolism" EXACT [] +synonym: "pyrimidine nucleoside biosynthesis" EXACT [] +synonym: "pyrimidine nucleoside formation" EXACT [] +synonym: "pyrimidine nucleoside synthesis" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process + +[Term] +id: GO:0046135 +name: pyrimidine nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:ai] +synonym: "pyrimidine nucleoside breakdown" EXACT [] +synonym: "pyrimidine nucleoside catabolism" EXACT [] +synonym: "pyrimidine nucleoside degradation" EXACT [] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process +is_a: GO:0009164 ! nucleoside catabolic process +is_a: GO:0072529 ! pyrimidine-containing compound catabolic process + +[Term] +id: GO:0046136 +name: positive regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +synonym: "activation of vitamin metabolic process" NARROW [] +synonym: "positive regulation of vitamin metabolism" EXACT [] +synonym: "stimulation of vitamin metabolic process" NARROW [] +synonym: "up regulation of vitamin metabolic process" EXACT [] +synonym: "up-regulation of vitamin metabolic process" EXACT [] +synonym: "upregulation of vitamin metabolic process" EXACT [] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0046137 +name: negative regulation of vitamin metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +synonym: "down regulation of vitamin metabolic process" EXACT [] +synonym: "down-regulation of vitamin metabolic process" EXACT [] +synonym: "downregulation of vitamin metabolic process" EXACT [] +synonym: "inhibition of vitamin metabolic process" NARROW [] +synonym: "negative regulation of vitamin metabolism" EXACT [] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006766 ! vitamin metabolic process + +[Term] +id: GO:0046138 +name: obsolete coenzyme and prosthetic group biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "coenzyme and prosthetic group anabolism" EXACT [] +synonym: "coenzyme and prosthetic group biosynthesis" EXACT [] +synonym: "coenzyme and prosthetic group biosynthetic process" EXACT [] +synonym: "coenzyme and prosthetic group formation" EXACT [] +synonym: "coenzyme and prosthetic group synthesis" EXACT [] +is_obsolete: true +consider: GO:0051191 + +[Term] +id: GO:0046139 +name: obsolete coenzyme and prosthetic group catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "coenzyme and prosthetic group breakdown" EXACT [] +synonym: "coenzyme and prosthetic group catabolic process" EXACT [] +synonym: "coenzyme and prosthetic group catabolism" EXACT [] +synonym: "coenzyme and prosthetic group degradation" EXACT [] +is_obsolete: true +consider: GO:0051190 + +[Term] +id: GO:0046140 +name: corrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] +synonym: "corrin anabolism" EXACT [] +synonym: "corrin biosynthesis" EXACT [] +synonym: "corrin formation" EXACT [] +synonym: "corrin synthesis" EXACT [] +is_a: GO:0015009 ! corrin metabolic process +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0046141 +name: corrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai] +synonym: "corrin breakdown" EXACT [] +synonym: "corrin catabolism" EXACT [] +synonym: "corrin degradation" EXACT [] +is_a: GO:0015009 ! corrin metabolic process +is_a: GO:0033015 ! tetrapyrrole catabolic process + +[Term] +id: GO:0046142 +name: obsolete negative regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "negative regulation of coenzyme and prosthetic group metabolic process" EXACT [] +is_obsolete: true +consider: GO:0051201 + +[Term] +id: GO:0046143 +name: obsolete positive regulation of coenzyme and prosthetic group metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] +comment: This term was made obsolete because it was replaced by more specific terms. +synonym: "positive regulation of coenzyme and prosthetic group metabolic process" EXACT [] +is_obsolete: true +consider: GO:0051200 + +[Term] +id: GO:0046144 +name: D-alanine family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-alanine and related amino acids." [GOC:ai] +synonym: "D-alanine family amino acid metabolism" EXACT [] +is_a: GO:0006522 ! alanine metabolic process + +[Term] +id: GO:0046145 +name: D-alanine family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids." [GOC:ai] +synonym: "D-alanine family amino acid anabolism" EXACT [] +synonym: "D-alanine family amino acid biosynthesis" EXACT [] +synonym: "D-alanine family amino acid formation" EXACT [] +synonym: "D-alanine family amino acid synthesis" EXACT [] +is_a: GO:0006523 ! alanine biosynthetic process +is_a: GO:0046144 ! D-alanine family amino acid metabolic process + +[Term] +id: GO:0046146 +name: tetrahydrobiopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [PMID:21871890] +synonym: "5,6,7,8-tetrahydrobiopterin metabolic process" EXACT [GOC:curators] +synonym: "tetrahydrobiopterin metabolism" EXACT [] +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:0046147 +name: tetrahydrobiopterin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732] +synonym: "5,6,7,8-tetrahydrobiopterin catabolic process" EXACT [Wikipedia:Tetrahydrobiopterin] +synonym: "tetrahydrobiopterin breakdown" EXACT [] +synonym: "tetrahydrobiopterin catabolism" EXACT [] +synonym: "tetrahydrobiopterin degradation" EXACT [] +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0042560 ! pteridine-containing compound catabolic process +is_a: GO:0046146 ! tetrahydrobiopterin metabolic process + +[Term] +id: GO:0046148 +name: pigment biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732] +synonym: "pigment anabolism" EXACT [] +synonym: "pigment biosynthesis" EXACT [] +synonym: "pigment formation" EXACT [] +synonym: "pigment synthesis" EXACT [] +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0046149 +name: pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [ISBN:0198506732] +synonym: "pigment breakdown" EXACT [] +synonym: "pigment catabolism" EXACT [] +synonym: "pigment degradation" EXACT [] +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0046150 +name: melanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [ISBN:0198506732] +synonym: "melanin breakdown" EXACT [] +synonym: "melanin catabolism" EXACT [] +synonym: "melanin degradation" EXACT [] +is_a: GO:0006582 ! melanin metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0046151 +name: eye pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] +synonym: "eye pigment breakdown" EXACT [] +synonym: "eye pigment catabolism" EXACT [] +synonym: "eye pigment degradation" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046149 ! pigment catabolic process + +[Term] +id: GO:0046152 +name: ommochrome metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] +synonym: "ommochrome metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0046158 ! ocellus pigment metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0046153 +name: ommochrome catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] +synonym: "ommochrome breakdown" EXACT [] +synonym: "ommochrome catabolism" EXACT [] +synonym: "ommochrome degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046151 ! eye pigment catabolic process +is_a: GO:0046152 ! ommochrome metabolic process +is_a: GO:0046159 ! ocellus pigment catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046154 +name: rhodopsin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] +synonym: "rhodopsin metabolism" EXACT [] +is_a: GO:0042441 ! eye pigment metabolic process +is_a: GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0046155 +name: rhodopsin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] +synonym: "rhodopsin breakdown" EXACT [] +synonym: "rhodopsin catabolism" EXACT [] +synonym: "rhodopsin degradation" EXACT [] +is_a: GO:0044257 ! cellular protein catabolic process +is_a: GO:0046151 ! eye pigment catabolic process +is_a: GO:0046154 ! rhodopsin metabolic process + +[Term] +id: GO:0046156 +name: siroheme metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] +synonym: "sirohaem metabolic process" EXACT [] +synonym: "sirohaem metabolism" EXACT [] +synonym: "siroheme metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046157 +name: siroheme catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] +synonym: "sirohaem catabolic process" EXACT [] +synonym: "sirohaem catabolism" EXACT [] +synonym: "siroheme breakdown" EXACT [] +synonym: "siroheme catabolism" EXACT [] +synonym: "siroheme degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046156 ! siroheme metabolic process + +[Term] +id: GO:0046158 +name: ocellus pigment metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] +synonym: "ocellus pigment metabolism" EXACT [] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0043474 ! pigment metabolic process involved in pigmentation +relationship: part_of GO:0033060 ! ocellus pigmentation + +[Term] +id: GO:0046159 +name: ocellus pigment catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] +synonym: "ocellus pigment breakdown" EXACT [] +synonym: "ocellus pigment catabolism" EXACT [] +synonym: "ocellus pigment degradation" EXACT [] +is_a: GO:0046149 ! pigment catabolic process +is_a: GO:0046158 ! ocellus pigment metabolic process + +[Term] +id: GO:0046160 +name: heme a metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme a, a derivative of heme found in cytochrome aa3." [GOC:curators] +synonym: "haem a metabolic process" EXACT [] +synonym: "haem a metabolism" EXACT [] +synonym: "heme a metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046161 +name: heme a catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme a, a derivative of heme found in cytochrome aa3." [GOC:curators, PMID:28352909] +synonym: "haem a catabolic process" EXACT [] +synonym: "haem a catabolism" EXACT [] +synonym: "heme a breakdown" EXACT [] +synonym: "heme a catabolism" EXACT [] +synonym: "heme a degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046160 ! heme a metabolic process + +[Term] +id: GO:0046162 +name: heme C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators] +synonym: "haem C metabolic process" EXACT [] +synonym: "haem C metabolism" EXACT [] +synonym: "heme C metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046163 +name: heme C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme C, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators] +synonym: "haem C catabolic process" EXACT [] +synonym: "haem C catabolism" EXACT [] +synonym: "heme C breakdown" EXACT [] +synonym: "heme C catabolism" EXACT [] +synonym: "heme C degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046162 ! heme C metabolic process + +[Term] +id: GO:0046164 +name: alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] +synonym: "alcohol breakdown" EXACT [] +synonym: "alcohol catabolism" EXACT [] +synonym: "alcohol degradation" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0046165 +name: alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [GOC:ai] +synonym: "alcohol anabolism" EXACT [] +synonym: "alcohol biosynthesis" EXACT [] +synonym: "alcohol formation" EXACT [] +synonym: "alcohol synthesis" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0046166 +name: glyceraldehyde-3-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai] +synonym: "glyceraldehyde 3-phosphate biosynthesis" EXACT [] +synonym: "glyceraldehyde 3-phosphate biosynthetic process" EXACT [] +synonym: "glyceraldehyde-3-phosphate anabolism" EXACT [] +synonym: "glyceraldehyde-3-phosphate biosynthesis" EXACT [] +synonym: "glyceraldehyde-3-phosphate formation" EXACT [] +synonym: "glyceraldehyde-3-phosphate synthesis" EXACT [] +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0046167 +name: glycerol-3-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] +synonym: "glycerol-3-phosphate anabolism" EXACT [] +synonym: "glycerol-3-phosphate biosynthesis" EXACT [] +synonym: "glycerol-3-phosphate formation" EXACT [] +synonym: "glycerol-3-phosphate synthesis" EXACT [] +is_a: GO:0006072 ! glycerol-3-phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0046168 +name: glycerol-3-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:ai] +synonym: "glycerol-3-phosphate breakdown" EXACT [] +synonym: "glycerol-3-phosphate catabolism" EXACT [] +synonym: "glycerol-3-phosphate degradation" EXACT [] +is_a: GO:0006072 ! glycerol-3-phosphate metabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0046169 +name: methanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] +synonym: "methanol anabolism" EXACT [] +synonym: "methanol biosynthesis" EXACT [] +synonym: "methanol formation" EXACT [] +synonym: "methanol synthesis" EXACT [] +is_a: GO:0015945 ! methanol metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process + +[Term] +id: GO:0046170 +name: methanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:ai] +synonym: "methanol breakdown" EXACT [] +synonym: "methanol catabolism" EXACT [] +synonym: "methanol degradation" EXACT [] +is_a: GO:0015945 ! methanol metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process + +[Term] +id: GO:0046171 +name: octanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] +synonym: "octanol anabolism" EXACT [] +synonym: "octanol biosynthesis" EXACT [] +synonym: "octanol formation" EXACT [] +synonym: "octanol synthesis" EXACT [] +is_a: GO:0006070 ! octanol metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:1903175 ! fatty alcohol biosynthetic process + +[Term] +id: GO:0046172 +name: octanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:ai] +synonym: "octanol breakdown" EXACT [] +synonym: "octanol catabolism" EXACT [] +synonym: "octanol degradation" EXACT [] +is_a: GO:0006070 ! octanol metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:1903174 ! fatty alcohol catabolic process + +[Term] +id: GO:0046173 +name: polyol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators] +synonym: "polyhydric alcohol biosynthetic process" EXACT [] +synonym: "polyol anabolism" EXACT [] +synonym: "polyol biosynthesis" EXACT [] +synonym: "polyol formation" EXACT [] +synonym: "polyol synthesis" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:0046174 +name: polyol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [GOC:curators] +synonym: "polyhydric alcohol catabolic process" EXACT [] +synonym: "polyol breakdown" EXACT [] +synonym: "polyol catabolism" EXACT [] +synonym: "polyol degradation" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0046164 ! alcohol catabolic process + +[Term] +id: GO:0046175 +name: aldonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] +synonym: "aldonic acid anabolism" EXACT [] +synonym: "aldonic acid biosynthesis" EXACT [] +synonym: "aldonic acid formation" EXACT [] +synonym: "aldonic acid synthesis" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0046176 +name: aldonic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] +synonym: "aldonic acid breakdown" EXACT [] +synonym: "aldonic acid catabolism" EXACT [] +synonym: "aldonic acid degradation" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0046177 +name: D-gluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "D-gluconate breakdown" EXACT [] +synonym: "D-gluconate catabolism" EXACT [] +synonym: "D-gluconate degradation" EXACT [] +xref: MetaCyc:GLUCONSUPER-PWY +is_a: GO:0019521 ! D-gluconate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0046178 +name: D-gluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "D-gluconate anabolism" EXACT [] +synonym: "D-gluconate biosynthesis" EXACT [] +synonym: "D-gluconate formation" EXACT [] +synonym: "D-gluconate synthesis" EXACT [] +is_a: GO:0019521 ! D-gluconate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046179 +name: keto-D-gluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] +synonym: "keto-D-gluconate anabolism" EXACT [] +synonym: "keto-D-gluconate biosynthesis" EXACT [] +synonym: "keto-D-gluconate formation" EXACT [] +synonym: "keto-D-gluconate synthesis" EXACT [] +is_a: GO:0019525 ! keto-D-gluconate metabolic process +is_a: GO:0046180 ! ketogluconate biosynthetic process + +[Term] +id: GO:0046180 +name: ketogluconate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] +synonym: "ketogluconate anabolism" EXACT [] +synonym: "ketogluconate biosynthesis" EXACT [] +synonym: "ketogluconate formation" EXACT [] +synonym: "ketogluconate synthesis" EXACT [] +is_a: GO:0019522 ! ketogluconate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046181 +name: ketogluconate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] +synonym: "ketogluconate breakdown" EXACT [] +synonym: "ketogluconate catabolism" EXACT [] +synonym: "ketogluconate degradation" EXACT [] +is_a: GO:0019522 ! ketogluconate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0046182 +name: L-idonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators] +synonym: "L-idonate anabolism" EXACT [] +synonym: "L-idonate biosynthesis" EXACT [] +synonym: "L-idonate formation" EXACT [] +synonym: "L-idonate synthesis" EXACT [] +is_a: GO:0019523 ! L-idonate metabolic process +is_a: GO:0046175 ! aldonic acid biosynthetic process + +[Term] +id: GO:0046183 +name: L-idonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:curators] +synonym: "L-idonate breakdown" EXACT [] +synonym: "L-idonate catabolism" EXACT [] +synonym: "L-idonate degradation" EXACT [] +is_a: GO:0019523 ! L-idonate metabolic process +is_a: GO:0046176 ! aldonic acid catabolic process + +[Term] +id: GO:0046184 +name: aldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] +synonym: "aldehyde anabolism" EXACT [] +synonym: "aldehyde biosynthesis" EXACT [] +synonym: "aldehyde formation" EXACT [] +synonym: "aldehyde synthesis" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0046185 +name: aldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] +synonym: "aldehyde breakdown" EXACT [] +synonym: "aldehyde catabolism" EXACT [] +synonym: "aldehyde degradation" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046186 +name: acetaldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] +synonym: "acetaldehyde anabolism" EXACT [] +synonym: "acetaldehyde biosynthesis" EXACT [] +synonym: "acetaldehyde formation" EXACT [] +synonym: "acetaldehyde synthesis" EXACT [] +is_a: GO:0006117 ! acetaldehyde metabolic process +is_a: GO:0046184 ! aldehyde biosynthetic process + +[Term] +id: GO:0046187 +name: acetaldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:ai] +synonym: "acetaldehyde breakdown" EXACT [] +synonym: "acetaldehyde catabolism" EXACT [] +synonym: "acetaldehyde degradation" EXACT [] +is_a: GO:0006117 ! acetaldehyde metabolic process +is_a: GO:0046185 ! aldehyde catabolic process + +[Term] +id: GO:0046188 +name: methane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] +synonym: "methane breakdown" EXACT [] +synonym: "methane catabolism" EXACT [] +synonym: "methane degradation" EXACT [] +is_a: GO:0015947 ! methane metabolic process +is_a: GO:0043448 ! alkane catabolic process + +[Term] +id: GO:0046189 +name: phenol-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [GOC:ai] +synonym: "phenol-containing compound anabolism" EXACT [] +synonym: "phenol-containing compound biosynthesis" EXACT [] +synonym: "phenol-containing compound formation" EXACT [] +synonym: "phenol-containing compound synthesis" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0046190 +name: aerobic phenol-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] +synonym: "aerobic phenol-containing compound anabolism" EXACT [] +synonym: "aerobic phenol-containing compound biosynthesis" EXACT [] +synonym: "aerobic phenol-containing compound formation" EXACT [] +synonym: "aerobic phenol-containing compound synthesis" EXACT [] +is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0046191 +name: aerobic phenol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [GOC:ai] +synonym: "aerobic phenol-containing compound breakdown" EXACT [] +synonym: "aerobic phenol-containing compound catabolism" EXACT [] +synonym: "aerobic phenol-containing compound degradation" EXACT [] +is_a: GO:0018959 ! aerobic phenol-containing compound metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process + +[Term] +id: GO:0046192 +name: anaerobic phenol-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai] +synonym: "anaerobic phenol-containing compound anabolism" EXACT [] +synonym: "anaerobic phenol-containing compound biosynthesis" EXACT [] +synonym: "anaerobic phenol-containing compound formation" EXACT [] +synonym: "anaerobic phenol-containing compound synthesis" EXACT [] +is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0046193 +name: anaerobic phenol-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [GOC:ai] +synonym: "anaerobic phenol-containing compound breakdown" EXACT [] +synonym: "anaerobic phenol-containing compound catabolism" EXACT [] +synonym: "anaerobic phenol-containing compound degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042215 ! anaerobic phenol-containing compound metabolic process + +[Term] +id: GO:0046194 +name: obsolete pentachlorophenol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:ai] +comment: This term was made obsolete because pentachlorophenol is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "pentachlorophenol anabolism" EXACT [] +synonym: "pentachlorophenol biosynthesis" EXACT [] +synonym: "pentachlorophenol biosynthetic process" EXACT [] +synonym: "pentachlorophenol formation" EXACT [] +synonym: "pentachlorophenol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018961 + +[Term] +id: GO:0046195 +name: obsolete 4-nitrophenol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] +comment: This term was made obsolete because 4-nitrophenol is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-nitrophenol anabolism" EXACT [] +synonym: "4-nitrophenol biosynthesis" EXACT [] +synonym: "4-nitrophenol biosynthetic process" EXACT [] +synonym: "4-nitrophenol formation" EXACT [] +synonym: "4-nitrophenol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018960 + +[Term] +id: GO:0046196 +name: 4-nitrophenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:ai] +synonym: "4-nitrophenol breakdown" EXACT [] +synonym: "4-nitrophenol catabolism" EXACT [] +synonym: "4-nitrophenol degradation" EXACT [] +is_a: GO:0018960 ! 4-nitrophenol metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046197 +name: orcinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:ai] +synonym: "orcinol anabolism" EXACT [] +synonym: "orcinol biosynthesis" EXACT [] +synonym: "orcinol formation" EXACT [] +synonym: "orcinol synthesis" EXACT [] +is_a: GO:0018940 ! orcinol metabolic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0046198 +name: obsolete cresol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] +comment: This term was made obsolete because cresol is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "cresol anabolism" EXACT [] +synonym: "cresol biosynthesis" EXACT [] +synonym: "cresol biosynthetic process" EXACT [] +synonym: "cresol formation" EXACT [] +synonym: "cresol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0042212 + +[Term] +id: GO:0046199 +name: cresol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [GOC:ai] +synonym: "cresol breakdown" EXACT [] +synonym: "cresol catabolism" EXACT [] +synonym: "cresol degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042212 ! cresol metabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process + +[Term] +id: GO:0046200 +name: obsolete m-cresol biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:ai] +comment: This term was made obsolete because m-cresol is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "m-cresol anabolism" EXACT [] +synonym: "m-cresol biosynthesis" EXACT [] +synonym: "m-cresol biosynthetic process" EXACT [] +synonym: "m-cresol formation" EXACT [] +synonym: "m-cresol synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018925 + +[Term] +id: GO:0046201 +name: cyanate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid." [GOC:ai] +synonym: "cyanate anabolism" EXACT [] +synonym: "cyanate biosynthesis" EXACT [] +synonym: "cyanate formation" EXACT [] +synonym: "cyanate synthesis" EXACT [] +is_a: GO:0009439 ! cyanate metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0046202 +name: cyanide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [GOC:ai] +synonym: "cyanide anabolism" EXACT [] +synonym: "cyanide biosynthesis" EXACT [] +synonym: "cyanide formation" EXACT [] +synonym: "cyanide synthesis" EXACT [] +is_a: GO:0019499 ! cyanide metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0046203 +name: spermidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +synonym: "spermidine breakdown" EXACT [] +synonym: "spermidine catabolism" EXACT [] +synonym: "spermidine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0008216 ! spermidine metabolic process + +[Term] +id: GO:0046204 +name: nor-spermidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +synonym: "nor-spermidine metabolism" EXACT [] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:0046205 +name: nor-spermidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] +synonym: "nor-spermidine breakdown" EXACT [] +synonym: "nor-spermidine catabolism" EXACT [] +synonym: "nor-spermidine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0046204 ! nor-spermidine metabolic process + +[Term] +id: GO:0046206 +name: trypanothione metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] +synonym: "trypanothione metabolism" EXACT [] +is_a: GO:1901685 ! glutathione derivative metabolic process + +[Term] +id: GO:0046207 +name: trypanothione catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trypanothione (N1,N6,-bis(glutathionyl)spermidine), an essential redox intermediate in intracellular thiol redox regulation which also plays a role in protecting against oxidative stress." [GOC:ai] +synonym: "trypanothione breakdown" EXACT [] +synonym: "trypanothione catabolism" EXACT [] +synonym: "trypanothione degradation" EXACT [] +is_a: GO:0046206 ! trypanothione metabolic process +is_a: GO:1901686 ! glutathione derivative catabolic process + +[Term] +id: GO:0046208 +name: spermine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [PMID:12141946] +synonym: "spermine breakdown" EXACT [] +synonym: "spermine catabolism" EXACT [] +synonym: "spermine degradation" EXACT [] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:0008215 ! spermine metabolic process + +[Term] +id: GO:0046209 +name: nitric oxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +synonym: "nitric oxide metabolism" EXACT [] +is_a: GO:2001057 ! reactive nitrogen species metabolic process + +[Term] +id: GO:0046210 +name: nitric oxide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] +synonym: "nitric oxide breakdown" EXACT [] +synonym: "nitric oxide catabolism" EXACT [] +synonym: "nitric oxide degradation" EXACT [] +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:0046211 +name: (+)-camphor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-camphor, a bicyclic monoterpene ketone." [GOC:ai] +synonym: "(+)-camphor anabolism" EXACT [] +synonym: "(+)-camphor biosynthesis" EXACT [] +synonym: "(+)-camphor formation" EXACT [] +synonym: "(+)-camphor synthesis" EXACT [] +is_a: GO:0016099 ! monoterpenoid biosynthetic process +is_a: GO:0018882 ! (+)-camphor metabolic process +is_a: GO:0042181 ! ketone biosynthetic process + +[Term] +id: GO:0046212 +name: obsolete methyl ethyl ketone biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [GOC:ai] +comment: This term was made obsolete because methyl ethyl ketone is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "methyl ethyl ketone anabolism" EXACT [] +synonym: "methyl ethyl ketone biosynthesis" EXACT [] +synonym: "methyl ethyl ketone biosynthetic process" EXACT [] +synonym: "methyl ethyl ketone formation" EXACT [] +synonym: "methyl ethyl ketone synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018928 + +[Term] +id: GO:0046213 +name: methyl ethyl ketone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor." [GOC:ai] +synonym: "methyl ethyl ketone breakdown" EXACT [] +synonym: "methyl ethyl ketone catabolism" EXACT [] +synonym: "methyl ethyl ketone degradation" EXACT [] +is_a: GO:0018928 ! methyl ethyl ketone metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0042182 ! ketone catabolic process + +[Term] +id: GO:0046214 +name: enterobactin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:ai] +synonym: "enterobactin breakdown" EXACT [] +synonym: "enterobactin catabolism" EXACT [] +synonym: "enterobactin degradation" EXACT [] +is_a: GO:0009238 ! enterobactin metabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0046215 ! siderophore catabolic process +is_a: GO:1901335 ! lactone catabolic process + +[Term] +id: GO:0046215 +name: siderophore catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:ai] +synonym: "siderochrome catabolism" NARROW [] +synonym: "siderophore breakdown" EXACT [] +synonym: "siderophore catabolism" EXACT [] +synonym: "siderophore degradation" EXACT [] +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process + +[Term] +id: GO:0046216 +name: indole phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] +synonym: "indole phytoalexin breakdown" EXACT [] +synonym: "indole phytoalexin catabolism" EXACT [] +synonym: "indole phytoalexin degradation" EXACT [] +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:0046217 ! indole phytoalexin metabolic process +is_a: GO:0051410 ! detoxification of nitrogen compound +is_a: GO:0052316 ! phytoalexin catabolic process + +[Term] +id: GO:0046217 +name: indole phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:ai] +synonym: "indole phytoalexin metabolism" EXACT [] +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0046218 +name: indolalkylamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] +synonym: "indolalkylamine breakdown" EXACT [] +synonym: "indolalkylamine catabolism" EXACT [] +synonym: "indolalkylamine degradation" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:0042436 ! indole-containing compound catabolic process + +[Term] +id: GO:0046219 +name: indolalkylamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [GOC:curators] +synonym: "indolalkylamine anabolism" EXACT [] +synonym: "indolalkylamine biosynthesis" EXACT [] +synonym: "indolalkylamine formation" EXACT [] +synonym: "indolalkylamine synthesis" EXACT [] +is_a: GO:0006586 ! indolalkylamine metabolic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process + +[Term] +id: GO:0046220 +name: pyridine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] +synonym: "pyridine anabolism" EXACT [] +synonym: "pyridine biosynthesis" EXACT [] +synonym: "pyridine formation" EXACT [] +synonym: "pyridine synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019507 ! pyridine metabolic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process + +[Term] +id: GO:0046221 +name: pyridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [GOC:ai] +synonym: "pyridine breakdown" EXACT [] +synonym: "pyridine catabolism" EXACT [] +synonym: "pyridine degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0019507 ! pyridine metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process + +[Term] +id: GO:0046222 +name: aflatoxin metabolic process +namespace: biological_process +alt_id: GO:0043389 +alt_id: GO:0043390 +alt_id: GO:0043391 +def: "The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] +synonym: "aflatoxin B metabolic process" NARROW [GOC:mah] +synonym: "aflatoxin B1 metabolic process" RELATED [] +synonym: "aflatoxin B1 metabolism" RELATED [] +synonym: "aflatoxin B2 metabolic process" RELATED [] +synonym: "aflatoxin B2 metabolism" RELATED [] +synonym: "aflatoxin metabolism" EXACT [] +is_a: GO:0043385 ! mycotoxin metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:0046223 +name: aflatoxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [GOC:ai] +synonym: "aflatoxin breakdown" EXACT [] +synonym: "aflatoxin catabolism" EXACT [] +synonym: "aflatoxin degradation" EXACT [] +is_a: GO:0043387 ! mycotoxin catabolic process +is_a: GO:0046222 ! aflatoxin metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:0046224 +name: bacteriocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] +synonym: "bacteriocin metabolism" EXACT [] +is_a: GO:0009404 ! toxin metabolic process +is_a: GO:0030650 ! peptide antibiotic metabolic process + +[Term] +id: GO:0046225 +name: bacteriocin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:ai] +synonym: "bacteriocin breakdown" EXACT [] +synonym: "bacteriocin catabolism" EXACT [] +synonym: "bacteriocin degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0030652 ! peptide antibiotic catabolic process +is_a: GO:0046224 ! bacteriocin metabolic process +is_a: GO:0051410 ! detoxification of nitrogen compound + +[Term] +id: GO:0046226 +name: coumarin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:ai] +synonym: "coumarin breakdown" EXACT [] +synonym: "coumarin catabolism" EXACT [] +synonym: "coumarin degradation" EXACT [] +is_a: GO:0009804 ! coumarin metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process + +[Term] +id: GO:0046227 +name: obsolete 2,4,5-trichlorophenoxyacetic acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] +comment: This term was made obsolete because 2,4,5-trichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2,4,5-trichlorophenoxyacetic acid anabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid biosynthesis" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid biosynthetic process" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid formation" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018980 + +[Term] +id: GO:0046228 +name: 2,4,5-trichlorophenoxyacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound widely used as a herbicide." [GOC:ai] +synonym: "2,4,5-trichlorophenoxyacetic acid breakdown" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid catabolism" EXACT [] +synonym: "2,4,5-trichlorophenoxyacetic acid degradation" EXACT [] +is_a: GO:0018980 ! 2,4,5-trichlorophenoxyacetic acid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0046229 +name: obsolete 2-aminobenzenesulfonate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] +comment: This term was made obsolete because 2-aminobenzenesulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2-aminobenzenesulfonate anabolism" EXACT [] +synonym: "2-aminobenzenesulfonate biosynthesis" EXACT [] +synonym: "2-aminobenzenesulfonate biosynthetic process" EXACT [] +synonym: "2-aminobenzenesulfonate formation" EXACT [] +synonym: "2-aminobenzenesulfonate synthesis" EXACT [] +synonym: "2-aminobenzenesulphonate biosynthesis" EXACT [] +synonym: "2-aminobenzenesulphonate biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018868 + +[Term] +id: GO:0046230 +name: 2-aminobenzenesulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [GOC:ai] +synonym: "2-aminobenzenesulfonate breakdown" EXACT [] +synonym: "2-aminobenzenesulfonate catabolism" EXACT [] +synonym: "2-aminobenzenesulfonate degradation" EXACT [] +synonym: "2-aminobenzenesulphonate catabolic process" EXACT [] +synonym: "2-aminobenzenesulphonate catabolism" EXACT [] +is_a: GO:0009310 ! amine catabolic process +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046231 +name: obsolete carbazole biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] +comment: This term was made obsolete because carbazole is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "carbazole anabolism" EXACT [] +synonym: "carbazole biosynthesis" EXACT [] +synonym: "carbazole biosynthetic process" EXACT [] +synonym: "carbazole formation" EXACT [] +synonym: "carbazole synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018884 + +[Term] +id: GO:0046232 +name: carbazole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:ai] +synonym: "carbazole breakdown" EXACT [] +synonym: "carbazole catabolism" EXACT [] +synonym: "carbazole degradation" EXACT [] +is_a: GO:0018884 ! carbazole metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0046233 +name: obsolete 3-hydroxyphenylacetate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [GOC:curator] +comment: This term was made obsolete because 3-hydroxyphenylacetate is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "3-hydroxyphenylacetate anabolism" EXACT [] +synonym: "3-hydroxyphenylacetate biosynthesis" EXACT [] +synonym: "3-hydroxyphenylacetate biosynthetic process" EXACT [] +synonym: "3-hydroxyphenylacetate formation" EXACT [] +synonym: "3-hydroxyphenylacetate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019609 + +[Term] +id: GO:0046234 +name: obsolete fluorene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:ai] +comment: This term was made obsolete because fluorene is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "fluorene anabolism" EXACT [] +synonym: "fluorene biosynthesis" EXACT [] +synonym: "fluorene biosynthetic process" EXACT [] +synonym: "fluorene formation" EXACT [] +synonym: "fluorene synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046235 +name: obsolete gallate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:ai] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "gallate anabolism" EXACT [] +synonym: "gallate biosynthesis" EXACT [] +synonym: "gallate formation" EXACT [] +synonym: "gallate synthesis" EXACT [] +synonym: "gallic acid biosynthesis" EXACT [] +synonym: "gallic acid biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046236 +name: mandelate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:ai] +synonym: "mandelate anabolism" EXACT [] +synonym: "mandelate biosynthesis" EXACT [] +synonym: "mandelate formation" EXACT [] +synonym: "mandelate synthesis" EXACT [] +is_a: GO:0018924 ! mandelate metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0046237 +name: obsolete phenanthrene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because phenanthrene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "phenanthrene anabolism" EXACT [] +synonym: "phenanthrene biosynthesis" EXACT [] +synonym: "phenanthrene biosynthetic process" EXACT [] +synonym: "phenanthrene formation" EXACT [] +synonym: "phenanthrene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018955 + +[Term] +id: GO:0046238 +name: obsolete phthalate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of phthalate, any ester or salt of phthalic acid." [GOC:ai] +comment: This term was made obsolete because phthalates are not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "phthalate anabolism" EXACT [] +synonym: "phthalate biosynthesis" EXACT [] +synonym: "phthalate biosynthetic process" EXACT [] +synonym: "phthalate formation" EXACT [] +synonym: "phthalate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018963 + +[Term] +id: GO:0046239 +name: phthalate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid." [GOC:ai] +synonym: "phthalate breakdown" EXACT [] +synonym: "phthalate catabolism" EXACT [] +synonym: "phthalate degradation" EXACT [] +is_a: GO:0018963 ! phthalate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046240 +name: obsolete xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:ai] +comment: This term was made obsolete because xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "xylene anabolism" EXACT [] +synonym: "xylene biosynthesis" EXACT [] +synonym: "xylene biosynthetic process" EXACT [] +synonym: "xylene formation" EXACT [] +synonym: "xylene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018948 + +[Term] +id: GO:0046241 +name: obsolete m-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because m-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "m-xylene anabolism" EXACT [] +synonym: "m-xylene biosynthesis" EXACT [] +synonym: "m-xylene biosynthetic process" EXACT [] +synonym: "m-xylene formation" EXACT [] +synonym: "m-xylene synthesis" EXACT [] +synonym: "meta-xylene biosynthesis" EXACT [] +synonym: "meta-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018949 + +[Term] +id: GO:0046242 +name: obsolete o-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because o-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "o-xylene anabolism" EXACT [] +synonym: "o-xylene biosynthesis" EXACT [] +synonym: "o-xylene biosynthetic process" EXACT [] +synonym: "o-xylene formation" EXACT [] +synonym: "o-xylene synthesis" EXACT [] +synonym: "ortho-xylene biosynthesis" EXACT [] +synonym: "ortho-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018950 + +[Term] +id: GO:0046243 +name: obsolete p-xylene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:ai] +comment: This term was made obsolete because p-xylene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "p-xylene anabolism" EXACT [] +synonym: "p-xylene biosynthesis" EXACT [] +synonym: "p-xylene biosynthetic process" EXACT [] +synonym: "p-xylene formation" EXACT [] +synonym: "p-xylene synthesis" EXACT [] +synonym: "para-xylene biosynthesis" EXACT [] +synonym: "para-xylene biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018951 + +[Term] +id: GO:0046244 +name: salicylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [GOC:ai] +synonym: "salicylic acid breakdown" EXACT [] +synonym: "salicylic acid catabolism" EXACT [] +synonym: "salicylic acid degradation" EXACT [] +is_a: GO:0009696 ! salicylic acid metabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0046245 +name: obsolete styrene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:ai] +comment: This term was made obsolete because styrene is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "styrene anabolism" EXACT [] +synonym: "styrene biosynthesis" EXACT [] +synonym: "styrene biosynthetic process" EXACT [] +synonym: "styrene formation" EXACT [] +synonym: "styrene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018966 + +[Term] +id: GO:0046246 +name: terpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] +synonym: "terpene anabolism" EXACT [] +synonym: "terpene biosynthesis" EXACT [] +synonym: "terpene formation" EXACT [] +synonym: "terpene synthesis" EXACT [] +is_a: GO:0008299 ! isoprenoid biosynthetic process +is_a: GO:0042214 ! terpene metabolic process +is_a: GO:0120251 ! hydrocarbon biosynthetic process + +[Term] +id: GO:0046247 +name: terpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of terpenes, any of a large group of hydrocarbons made up of isoprene units." [GOC:ai] +synonym: "terpene breakdown" EXACT [] +synonym: "terpene catabolism" EXACT [] +synonym: "terpene degradation" EXACT [] +is_a: GO:0008300 ! isoprenoid catabolic process +is_a: GO:0042214 ! terpene metabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process + +[Term] +id: GO:0046248 +name: alpha-pinene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] +synonym: "alpha-pinene anabolism" EXACT [] +synonym: "alpha-pinene biosynthesis" EXACT [] +synonym: "alpha-pinene formation" EXACT [] +synonym: "alpha-pinene synthesis" EXACT [] +is_a: GO:0018867 ! alpha-pinene metabolic process +is_a: GO:0043693 ! monoterpene biosynthetic process + +[Term] +id: GO:0046249 +name: alpha-pinene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature." [GOC:ai] +synonym: "alpha-pinene breakdown" EXACT [] +synonym: "alpha-pinene catabolism" EXACT [] +synonym: "alpha-pinene degradation" EXACT [] +is_a: GO:0018867 ! alpha-pinene metabolic process +is_a: GO:0033074 ! pinene catabolic process + +[Term] +id: GO:0046250 +name: limonene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] +synonym: "limonene anabolism" EXACT [] +synonym: "limonene biosynthesis" EXACT [] +synonym: "limonene formation" EXACT [] +synonym: "limonene synthesis" EXACT [] +is_a: GO:0018923 ! limonene metabolic process +is_a: GO:0043693 ! monoterpene biosynthetic process +is_a: GO:1900674 ! olefin biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0046251 +name: limonene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [GOC:ai] +synonym: "limonene breakdown" EXACT [] +synonym: "limonene catabolism" EXACT [] +synonym: "limonene degradation" EXACT [] +is_a: GO:0018923 ! limonene metabolic process +is_a: GO:0043694 ! monoterpene catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046252 +name: toluene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:ai, PMID:6508079] +comment: This term was reinstated from obsolete. +synonym: "toluene anabolism" EXACT [] +synonym: "toluene biosynthesis" EXACT [] +synonym: "toluene formation" EXACT [] +synonym: "toluene synthesis" EXACT [] +is_a: GO:0018970 ! toluene metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0120251 ! hydrocarbon biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0046253 +name: anaerobic toluene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai, PMID:8573493] +comment: This term was reinstated from obsolete. +synonym: "anaerobic toluene anabolism" EXACT [] +synonym: "anaerobic toluene biosynthesis" EXACT [] +synonym: "anaerobic toluene formation" EXACT [] +synonym: "anaerobic toluene synthesis" EXACT [] +is_a: GO:0018971 ! anaerobic toluene metabolic process +is_a: GO:0046252 ! toluene biosynthetic process + +[Term] +id: GO:0046254 +name: anaerobic toluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen." [GOC:ai] +synonym: "anaerobic toluene breakdown" EXACT [] +synonym: "anaerobic toluene catabolism" EXACT [] +synonym: "anaerobic toluene degradation" EXACT [] +xref: MetaCyc:PWY-81 +is_a: GO:0042203 ! toluene catabolic process + +[Term] +id: GO:0046255 +name: obsolete 2,4,6-trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2,4,6-trinitrotoluene anabolism" EXACT [] +synonym: "2,4,6-trinitrotoluene biosynthesis" EXACT [] +synonym: "2,4,6-trinitrotoluene biosynthetic process" EXACT [] +synonym: "2,4,6-trinitrotoluene formation" EXACT [] +synonym: "2,4,6-trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018974 + +[Term] +id: GO:0046256 +name: 2,4,6-trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid." [GOC:ai] +synonym: "2,4,6-trinitrotoluene breakdown" EXACT [] +synonym: "2,4,6-trinitrotoluene catabolism" EXACT [] +synonym: "2,4,6-trinitrotoluene degradation" EXACT [] +is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process +is_a: GO:0046260 ! trinitrotoluene catabolic process + +[Term] +id: GO:0046257 +name: obsolete anaerobic 2,4,6-trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] +comment: This term was made obsolete because 2,4,6-trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "anaerobic 2,4,6-trinitrotoluene anabolism" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene biosynthesis" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene biosynthetic process" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene formation" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018975 + +[Term] +id: GO:0046258 +name: anaerobic 2,4,6-trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen." [GOC:ai] +synonym: "anaerobic 2,4,6-trinitrotoluene breakdown" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene catabolism" EXACT [] +synonym: "anaerobic 2,4,6-trinitrotoluene degradation" EXACT [] +is_a: GO:0018975 ! anaerobic 2,4,6-trinitrotoluene metabolic process +is_a: GO:0046256 ! 2,4,6-trinitrotoluene catabolic process + +[Term] +id: GO:0046259 +name: obsolete trinitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it." [GOC:ai] +comment: This term was made obsolete because trinitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "trinitrotoluene anabolism" EXACT [] +synonym: "trinitrotoluene biosynthesis" EXACT [] +synonym: "trinitrotoluene biosynthetic process" EXACT [] +synonym: "trinitrotoluene formation" EXACT [] +synonym: "trinitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018973 + +[Term] +id: GO:0046260 +name: trinitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trinitrotoluene, a methylated benzene entity with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] +synonym: "trinitrotoluene breakdown" EXACT [] +synonym: "trinitrotoluene catabolism" EXACT [] +synonym: "trinitrotoluene degradation" EXACT [] +is_a: GO:0018973 ! trinitrotoluene metabolic process +is_a: GO:0046263 ! nitrotoluene catabolic process + +[Term] +id: GO:0046261 +name: obsolete 4-nitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] +comment: This term was made obsolete because 4-nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-nitrotoluene anabolism" EXACT [] +synonym: "4-nitrotoluene biosynthesis" EXACT [] +synonym: "4-nitrotoluene biosynthetic process" EXACT [] +synonym: "4-nitrotoluene formation" EXACT [] +synonym: "4-nitrotoluene synthesis" EXACT [] +synonym: "4NT biosynthesis" EXACT [] +synonym: "4NT biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0019257 + +[Term] +id: GO:0046262 +name: obsolete nitrotoluene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +comment: This term was made obsolete because nitrotoluene is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "nitrotoluene anabolism" EXACT [] +synonym: "nitrotoluene biosynthesis" EXACT [] +synonym: "nitrotoluene biosynthetic process" EXACT [] +synonym: "nitrotoluene formation" EXACT [] +synonym: "nitrotoluene synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019326 + +[Term] +id: GO:0046263 +name: nitrotoluene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] +synonym: "nitrotoluene breakdown" EXACT [] +synonym: "nitrotoluene catabolism" EXACT [] +synonym: "nitrotoluene degradation" EXACT [] +is_a: GO:0019326 ! nitrotoluene metabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process + +[Term] +id: GO:0046264 +name: obsolete thiocyanate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of thiocyanate, any anion or salt of thiocyanic acid." [GOC:ai] +comment: This term was made obsolete because thiocyanates are not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "thiocyanate anabolism" EXACT [] +synonym: "thiocyanate biosynthesis" EXACT [] +synonym: "thiocyanate biosynthetic process" EXACT [] +synonym: "thiocyanate formation" EXACT [] +synonym: "thiocyanate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018969 + +[Term] +id: GO:0046265 +name: thiocyanate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid." [GOC:ai] +synonym: "thiocyanate breakdown" EXACT [] +synonym: "thiocyanate catabolism" EXACT [] +synonym: "thiocyanate degradation" EXACT [] +is_a: GO:0018969 ! thiocyanate metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046266 +name: obsolete triethanolamine biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] +comment: This term was made obsolete because triethanolamine is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "triethanolamine anabolism" EXACT [] +synonym: "triethanolamine biosynthesis" EXACT [] +synonym: "triethanolamine biosynthetic process" EXACT [] +synonym: "triethanolamine formation" EXACT [] +synonym: "triethanolamine synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018981 + +[Term] +id: GO:0046267 +name: triethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:ai] +synonym: "triethanolamine breakdown" EXACT [] +synonym: "triethanolamine catabolism" EXACT [] +synonym: "triethanolamine degradation" EXACT [] +is_a: GO:0018981 ! triethanolamine metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0046268 +name: obsolete toluene-4-sulfonate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] +comment: This term was made obsolete because toluene-4-sulfonate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "4-toluenesulfonate biosynthesis" EXACT [] +synonym: "4-toluenesulfonate biosynthetic process" EXACT [] +synonym: "toluene-4-sulfonate anabolism" EXACT [] +synonym: "toluene-4-sulfonate biosynthesis" EXACT [] +synonym: "toluene-4-sulfonate biosynthetic process" EXACT [] +synonym: "toluene-4-sulfonate formation" EXACT [] +synonym: "toluene-4-sulfonate synthesis" EXACT [] +synonym: "toluene-4-sulphonate biosynthesis" EXACT [] +synonym: "toluene-4-sulphonate biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0018972 + +[Term] +id: GO:0046269 +name: toluene-4-sulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule." [GOC:ai] +synonym: "4-toluenesulfonate catabolic process" EXACT [] +synonym: "4-toluenesulfonate catabolism" EXACT [] +synonym: "toluene-4-sulfonate breakdown" EXACT [] +synonym: "toluene-4-sulfonate catabolism" EXACT [] +synonym: "toluene-4-sulfonate degradation" EXACT [] +synonym: "toluene-4-sulphonate catabolic process" EXACT [] +synonym: "toluene-4-sulphonate catabolism" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0018972 ! toluene-4-sulfonate metabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0072491 ! toluene-containing compound catabolic process + +[Term] +id: GO:0046270 +name: obsolete 4-toluenecarboxylate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] +comment: This term was made obsolete because 4-toluenecarboxylate is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "4-toluenecarboxylate anabolism" EXACT [] +synonym: "4-toluenecarboxylate biosynthesis" EXACT [] +synonym: "4-toluenecarboxylate biosynthetic process" EXACT [] +synonym: "4-toluenecarboxylate formation" EXACT [] +synonym: "4-toluenecarboxylate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0019611 + +[Term] +id: GO:0046271 +name: phenylpropanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid." [GOC:ai] +synonym: "phenylpropanoid breakdown" EXACT [] +synonym: "phenylpropanoid catabolism" EXACT [] +synonym: "phenylpropanoid degradation" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046272 +name: stilbene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:ai] +synonym: "stilbene breakdown" EXACT [] +synonym: "stilbene catabolism" EXACT [] +synonym: "stilbene degradation" EXACT [] +is_a: GO:0009810 ! stilbene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046273 +name: lignan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] +synonym: "lignan breakdown" EXACT [] +synonym: "lignan catabolism" EXACT [] +synonym: "lignan degradation" EXACT [] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046274 +name: lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units." [GOC:ai] +synonym: "lignin breakdown" EXACT [] +synonym: "lignin catabolism" EXACT [] +synonym: "lignin degradation" EXACT [] +is_a: GO:0009808 ! lignin metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process + +[Term] +id: GO:0046275 +name: flavonoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:ai] +synonym: "flavonoid breakdown" EXACT [] +synonym: "flavonoid catabolism" EXACT [] +synonym: "flavonoid degradation" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046276 +name: methylgallate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +synonym: "methylgallate breakdown" EXACT [] +synonym: "methylgallate catabolism" EXACT [] +synonym: "methylgallate degradation" EXACT [] +xref: MetaCyc:METHYLGALLATE-DEGRADATION-PWY +is_a: GO:0019489 ! methylgallate metabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0046277 +name: methylgallate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] +synonym: "methylgallate anabolism" EXACT [] +synonym: "methylgallate biosynthesis" EXACT [] +synonym: "methylgallate formation" EXACT [] +synonym: "methylgallate synthesis" EXACT [] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0019489 ! methylgallate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0046278 +name: 3,4-dihydroxybenzoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid)." [GOC:ai, PMID:24359411] +synonym: "protocatechuate metabolic process" EXACT [PMID:25072253] +synonym: "protocatechuate metabolism" EXACT [] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0046279 +name: 3,4-dihydroxybenzoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate." [GOC:ai] +synonym: "protocatechuate anabolism" EXACT [] +synonym: "protocatechuate biosynthesis" EXACT [] +synonym: "protocatechuate biosynthetic process" EXACT [PMID:25072253] +synonym: "protocatechuate formation" EXACT [] +synonym: "protocatechuate synthesis" EXACT [] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0046280 +name: chalcone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:ai] +synonym: "chalcone breakdown" EXACT [] +synonym: "chalcone catabolism" EXACT [] +synonym: "chalcone degradation" EXACT [] +is_a: GO:0009714 ! chalcone metabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0046281 +name: cinnamic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:ai] +synonym: "cinnamic acid breakdown" EXACT [] +synonym: "cinnamic acid catabolism" EXACT [] +synonym: "cinnamic acid degradation" EXACT [] +synonym: "cinnamylic acid catabolic process" EXACT [] +synonym: "cinnamylic acid catabolism" EXACT [] +synonym: "phenylacrylic acid catabolic process" EXACT [] +synonym: "phenylacrylic acid catabolism" EXACT [] +is_a: GO:0009803 ! cinnamic acid metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0046282 +name: cinnamic acid ester catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:ai] +synonym: "cinnamic acid ester breakdown" EXACT [] +synonym: "cinnamic acid ester catabolism" EXACT [] +synonym: "cinnamic acid ester degradation" EXACT [] +is_a: GO:0009801 ! cinnamic acid ester metabolic process +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0046283 +name: anthocyanin-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers." [ISBN:0198506732] +synonym: "anthocyanin metabolic process" EXACT [] +synonym: "anthocyanin metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0046284 +name: anthocyanin-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] +synonym: "anthocyanin breakdown" EXACT [] +synonym: "anthocyanin catabolic process" EXACT [] +synonym: "anthocyanin catabolism" EXACT [] +synonym: "anthocyanin degradation" EXACT [] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0046149 ! pigment catabolic process +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:0046283 ! anthocyanin-containing compound metabolic process + +[Term] +id: GO:0046285 +name: flavonoid phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] +synonym: "flavonoid phytoalexin metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process + +[Term] +id: GO:0046286 +name: flavonoid phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +synonym: "flavonoid phytoalexin breakdown" EXACT [] +synonym: "flavonoid phytoalexin catabolism" EXACT [] +synonym: "flavonoid phytoalexin degradation" EXACT [] +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:0046285 ! flavonoid phytoalexin metabolic process +is_a: GO:0052316 ! phytoalexin catabolic process + +[Term] +id: GO:0046287 +name: isoflavonoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group." [GOC:ai, PMID:15734910] +synonym: "isoflavonoid metabolism" EXACT [] +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046288 +name: isoflavonoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] +synonym: "isoflavonoid breakdown" EXACT [] +synonym: "isoflavonoid catabolism" EXACT [] +synonym: "isoflavonoid degradation" EXACT [] +is_a: GO:0046271 ! phenylpropanoid catabolic process +is_a: GO:0046287 ! isoflavonoid metabolic process +is_a: GO:0046700 ! heterocycle catabolic process + +[Term] +id: GO:0046289 +name: isoflavonoid phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +synonym: "isoflavonoid phytoalexin metabolism" EXACT [] +is_a: GO:0046287 ! isoflavonoid metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0046290 +name: isoflavonoid phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] +synonym: "isoflavonoid phytoalexin breakdown" EXACT [] +synonym: "isoflavonoid phytoalexin catabolism" EXACT [] +synonym: "isoflavonoid phytoalexin degradation" EXACT [] +is_a: GO:0046288 ! isoflavonoid catabolic process +is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process +is_a: GO:0052316 ! phytoalexin catabolic process + +[Term] +id: GO:0046291 +name: obsolete 6-hydroxycineole biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] +comment: This term was made obsolete because 6-hydroxycineole is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "6-endo-hydroxycineole biosynthesis" EXACT [] +synonym: "6-endo-hydroxycineole biosynthetic process" EXACT [] +synonym: "6-hydroxycineole anabolism" EXACT [] +synonym: "6-hydroxycineole biosynthesis" EXACT [] +synonym: "6-hydroxycineole biosynthetic process" EXACT [] +synonym: "6-hydroxycineole formation" EXACT [] +synonym: "6-hydroxycineole synthesis" EXACT [] +synonym: "hydroxycineol biosynthesis" EXACT [] +synonym: "hydroxycineol biosynthetic process" EXACT [] +is_obsolete: true +replaced_by: GO:0019638 + +[Term] +id: GO:0046292 +name: formaldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent." [GOC:ai] +synonym: "formaldehyde metabolism" EXACT [] +synonym: "methanal metabolic process" EXACT [] +synonym: "methanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0046293 +name: formaldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] +synonym: "formaldehyde anabolism" EXACT [] +synonym: "formaldehyde biosynthesis" EXACT [] +synonym: "formaldehyde formation" EXACT [] +synonym: "formaldehyde synthesis" EXACT [] +synonym: "methanal biosynthesis" EXACT [] +synonym: "methanal biosynthetic process" EXACT [] +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0046292 ! formaldehyde metabolic process + +[Term] +id: GO:0046294 +name: formaldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde." [GOC:ai] +synonym: "formaldehyde breakdown" EXACT [] +synonym: "formaldehyde catabolism" EXACT [] +synonym: "formaldehyde degradation" EXACT [] +synonym: "methanal catabolic process" EXACT [] +synonym: "methanal catabolism" EXACT [] +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046292 ! formaldehyde metabolic process +is_a: GO:0110095 ! cellular detoxification of aldehyde + +[Term] +id: GO:0046295 +name: glycolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] +synonym: "glycolate anabolism" EXACT [] +synonym: "glycolate biosynthesis" EXACT [] +synonym: "glycolate formation" EXACT [] +synonym: "glycolate synthesis" EXACT [] +is_a: GO:0009441 ! glycolate metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0046296 +name: glycolate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai] +synonym: "glycolate breakdown" EXACT [] +synonym: "glycolate catabolism" EXACT [] +synonym: "glycolate degradation" EXACT [] +is_a: GO:0009441 ! glycolate metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0046297 +name: obsolete 2,4-dichlorobenzoate biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] +comment: This term was made obsolete because 2,4-dichlorobenzoate is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2,4-dichlorobenzoate anabolism" EXACT [] +synonym: "2,4-dichlorobenzoate biosynthesis" EXACT [] +synonym: "2,4-dichlorobenzoate biosynthetic process" EXACT [] +synonym: "2,4-dichlorobenzoate formation" EXACT [] +synonym: "2,4-dichlorobenzoate synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018898 + +[Term] +id: GO:0046298 +name: 2,4-dichlorobenzoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:ai] +synonym: "2,4-dichlorobenzoate breakdown" EXACT [] +synonym: "2,4-dichlorobenzoate catabolism" EXACT [] +synonym: "2,4-dichlorobenzoate degradation" EXACT [] +is_a: GO:0018898 ! 2,4-dichlorobenzoate metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0046299 +name: obsolete 2,4-dichlorophenoxyacetic acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] +comment: This term was made obsolete because 2,4-dichlorophenoxyacetic acid is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2,4-dichlorophenoxyacetic acid anabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid biosynthesis" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid biosynthetic process" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid formation" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018901 + +[Term] +id: GO:0046300 +name: 2,4-dichlorophenoxyacetic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [GOC:ai] +synonym: "2,4-dichlorophenoxyacetic acid breakdown" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid catabolism" EXACT [] +synonym: "2,4-dichlorophenoxyacetic acid degradation" EXACT [] +is_a: GO:0018901 ! 2,4-dichlorophenoxyacetic acid metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:0046301 +name: obsolete 2-chloro-N-isopropylacetanilide biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] +comment: This term was made obsolete because 2-chloro-N-isopropylacetanilide is not synthesized by living organisms and GO does not cover non-biological processes. +synonym: "2-chloro-N-isopropylacetanilide anabolism" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide biosynthesis" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide biosynthetic process" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide formation" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018889 + +[Term] +id: GO:0046302 +name: 2-chloro-N-isopropylacetanilide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [GOC:ai] +synonym: "2-chloro-N-isopropylacetanilide breakdown" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide catabolism" EXACT [] +synonym: "2-chloro-N-isopropylacetanilide degradation" EXACT [] +is_a: GO:0018889 ! 2-chloro-N-isopropylacetanilide metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0046303 +name: obsolete 2-nitropropane biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] +comment: This term was made obsolete because 2-nitropropane is not synthesized by living organisms, and GO does not cover non-biological processes. +synonym: "2-nitropropane anabolism" EXACT [] +synonym: "2-nitropropane biosynthesis" EXACT [] +synonym: "2-nitropropane biosynthetic process" EXACT [] +synonym: "2-nitropropane formation" EXACT [] +synonym: "2-nitropropane synthesis" EXACT [] +is_obsolete: true +replaced_by: GO:0018938 + +[Term] +id: GO:0046304 +name: 2-nitropropane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor." [GOC:ai] +synonym: "2-nitropropane breakdown" EXACT [] +synonym: "2-nitropropane catabolism" EXACT [] +synonym: "2-nitropropane degradation" EXACT [] +is_a: GO:0018938 ! 2-nitropropane metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046305 +name: alkanesulfonate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] +synonym: "alkanesulfonate anabolism" EXACT [] +synonym: "alkanesulfonate biosynthesis" EXACT [] +synonym: "alkanesulfonate formation" EXACT [] +synonym: "alkanesulfonate synthesis" EXACT [] +synonym: "alkanesulphonate biosynthesis" EXACT [] +synonym: "alkanesulphonate biosynthetic process" EXACT [] +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0046306 +name: alkanesulfonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] +synonym: "alkanesulfonate breakdown" EXACT [] +synonym: "alkanesulfonate catabolism" EXACT [] +synonym: "alkanesulfonate degradation" EXACT [] +synonym: "alkanesulphonate catabolic process" EXACT [] +synonym: "alkanesulphonate catabolism" EXACT [] +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046307 +name: Z-phenylacetaldoxime biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] +synonym: "Z-phenylacetaldoxime anabolism" EXACT [] +synonym: "Z-phenylacetaldoxime biosynthesis" EXACT [] +synonym: "Z-phenylacetaldoxime formation" EXACT [] +synonym: "Z-phenylacetaldoxime synthesis" EXACT [] +is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0046308 +name: Z-phenylacetaldoxime catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." [GOC:ai] +synonym: "Z-phenylacetaldoxime breakdown" EXACT [] +synonym: "Z-phenylacetaldoxime catabolism" EXACT [] +synonym: "Z-phenylacetaldoxime degradation" EXACT [] +is_a: GO:0018983 ! Z-phenylacetaldoxime metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046309 +name: 1,3-dichloro-2-propanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] +synonym: "1,3-dichloro-2-propanol anabolism" EXACT [] +synonym: "1,3-dichloro-2-propanol biosynthesis" EXACT [] +synonym: "1,3-dichloro-2-propanol formation" EXACT [] +synonym: "1,3-dichloro-2-propanol synthesis" EXACT [] +is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process +is_a: GO:0044108 ! cellular alcohol biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0046310 +name: 1,3-dichloro-2-propanol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic." [GOC:ai] +synonym: "1,3-dichloro-2-propanol breakdown" EXACT [] +synonym: "1,3-dichloro-2-propanol catabolism" EXACT [] +synonym: "1,3-dichloro-2-propanol degradation" EXACT [] +is_a: GO:0018902 ! 1,3-dichloro-2-propanol metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:0044109 ! cellular alcohol catabolic process + +[Term] +id: GO:0046311 +name: prenylcysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] +synonym: "prenylcysteine anabolism" EXACT [] +synonym: "prenylcysteine biosynthesis" EXACT [] +synonym: "prenylcysteine formation" EXACT [] +synonym: "prenylcysteine synthesis" EXACT [] +is_a: GO:0030329 ! prenylcysteine metabolic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process + +[Term] +id: GO:0046312 +name: phosphoarginine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] +synonym: "phosphoarginine anabolism" EXACT [] +synonym: "phosphoarginine biosynthesis" EXACT [] +synonym: "phosphoarginine formation" EXACT [] +synonym: "phosphoarginine synthesis" EXACT [] +is_a: GO:0006604 ! phosphoarginine metabolic process +is_a: GO:0042396 ! phosphagen biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0046313 +name: phosphoarginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphoarginine, a phosphorylated derivative of the amino acid arginine." [GOC:ai] +synonym: "phosphoarginine breakdown" EXACT [] +synonym: "phosphoarginine catabolism" EXACT [] +synonym: "phosphoarginine degradation" EXACT [] +is_a: GO:0006604 ! phosphoarginine metabolic process +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0042397 ! phosphagen catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0046314 +name: phosphocreatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] +synonym: "phosphocreatine anabolism" EXACT [] +synonym: "phosphocreatine biosynthesis" EXACT [] +synonym: "phosphocreatine formation" EXACT [] +synonym: "phosphocreatine synthesis" EXACT [] +is_a: GO:0006603 ! phosphocreatine metabolic process +is_a: GO:0042396 ! phosphagen biosynthetic process + +[Term] +id: GO:0046315 +name: phosphocreatine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase." [GOC:ai] +synonym: "phosphocreatine breakdown" EXACT [] +synonym: "phosphocreatine catabolism" EXACT [] +synonym: "phosphocreatine degradation" EXACT [] +is_a: GO:0006603 ! phosphocreatine metabolic process +is_a: GO:0042397 ! phosphagen catabolic process + +[Term] +id: GO:0046316 +name: gluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.12, RHEA:19433] +synonym: "ATP:D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.12] +synonym: "gluconate kinase activity" RELATED [EC:2.7.1.12] +synonym: "gluconokinase (phosphorylating)" RELATED [EC:2.7.1.12] +xref: EC:2.7.1.12 +xref: KEGG_REACTION:R01737 +xref: MetaCyc:GLUCONOKIN-RXN +xref: RHEA:19433 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0046317 +name: regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of glucosylceramide anabolism" EXACT [] +synonym: "regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "regulation of glucosylceramide formation" EXACT [] +synonym: "regulation of glucosylceramide synthesis" EXACT [] +is_a: GO:2000303 ! regulation of ceramide biosynthetic process +relationship: regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046318 +name: negative regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "down regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "down-regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "downregulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "inhibition of glucosylceramide biosynthetic process" NARROW [] +synonym: "negative regulation of glucosylceramide anabolism" EXACT [] +synonym: "negative regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "negative regulation of glucosylceramide formation" EXACT [] +synonym: "negative regulation of glucosylceramide synthesis" EXACT [] +is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process +is_a: GO:1900060 ! negative regulation of ceramide biosynthetic process +relationship: negatively_regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046319 +name: positive regulation of glucosylceramide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosylceramide." [GOC:ai] +synonym: "activation of glucosylceramide biosynthetic process" NARROW [] +synonym: "positive regulation of glucosylceramide anabolism" EXACT [] +synonym: "positive regulation of glucosylceramide biosynthesis" EXACT [] +synonym: "positive regulation of glucosylceramide formation" EXACT [] +synonym: "positive regulation of glucosylceramide synthesis" EXACT [] +synonym: "stimulation of glucosylceramide biosynthetic process" NARROW [] +synonym: "up regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "up-regulation of glucosylceramide biosynthetic process" EXACT [] +synonym: "upregulation of glucosylceramide biosynthetic process" EXACT [] +is_a: GO:0046317 ! regulation of glucosylceramide biosynthetic process +is_a: GO:2000304 ! positive regulation of ceramide biosynthetic process +relationship: positively_regulates GO:0006679 ! glucosylceramide biosynthetic process + +[Term] +id: GO:0046320 +name: regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +relationship: regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046321 +name: positive regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +synonym: "activation of fatty acid oxidation" NARROW [] +synonym: "stimulation of fatty acid oxidation" NARROW [] +synonym: "up regulation of fatty acid oxidation" EXACT [] +synonym: "up-regulation of fatty acid oxidation" EXACT [] +synonym: "upregulation of fatty acid oxidation" EXACT [] +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +relationship: positively_regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046322 +name: negative regulation of fatty acid oxidation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid oxidation." [GOC:ai] +synonym: "down regulation of fatty acid oxidation" EXACT [] +synonym: "down-regulation of fatty acid oxidation" EXACT [] +synonym: "downregulation of fatty acid oxidation" EXACT [] +synonym: "inhibition of fatty acid oxidation" NARROW [] +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0046320 ! regulation of fatty acid oxidation +relationship: negatively_regulates GO:0019395 ! fatty acid oxidation + +[Term] +id: GO:0046323 +name: glucose import +namespace: biological_process +def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb] +xref: Wikipedia:Glucose_uptake +is_a: GO:1904659 ! glucose transmembrane transport + +[Term] +id: GO:0046324 +name: regulation of glucose import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +synonym: "regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010827 ! regulation of glucose transmembrane transport +relationship: regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046325 +name: negative regulation of glucose import +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] +synonym: "down regulation of glucose import" EXACT [] +synonym: "down-regulation of glucose import" EXACT [] +synonym: "downregulation of glucose import" EXACT [] +synonym: "inhibition of glucose import" NARROW [] +synonym: "negative regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010829 ! negative regulation of glucose transmembrane transport +is_a: GO:0046324 ! regulation of glucose import +relationship: negatively_regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046326 +name: positive regulation of glucose import +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "activation of glucose import" NARROW [] +synonym: "positive regulation of glucose uptake" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of glucose import" NARROW [] +synonym: "up regulation of glucose import" EXACT [] +synonym: "up-regulation of glucose import" EXACT [] +synonym: "upregulation of glucose import" EXACT [] +is_a: GO:0010828 ! positive regulation of glucose transmembrane transport +is_a: GO:0046324 ! regulation of glucose import +relationship: positively_regulates GO:0046323 ! glucose import + +[Term] +id: GO:0046327 +name: glycerol biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate." [GOC:ai] +synonym: "glycerol anabolism from pyruvate" EXACT [] +synonym: "glycerol formation from pyruvate" EXACT [] +synonym: "glycerol synthesis from pyruvate" EXACT [] +synonym: "glyceroneogenesis" EXACT [] +is_a: GO:0006090 ! pyruvate metabolic process +is_a: GO:0006114 ! glycerol biosynthetic process +relationship: part_of GO:0019432 ! triglyceride biosynthetic process + +[Term] +id: GO:0046328 +name: regulation of JNK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "regulation of SAPK cascade" BROAD [] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +relationship: regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046329 +name: negative regulation of JNK cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "down regulation of JNK cascade" EXACT [] +synonym: "down-regulation of JNK cascade" EXACT [] +synonym: "downregulation of JNK cascade" EXACT [] +synonym: "inhibition of JNK cascade" NARROW [] +is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade +is_a: GO:0046328 ! regulation of JNK cascade +relationship: negatively_regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046330 +name: positive regulation of JNK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade." [GOC:bf] +synonym: "activation of JNK cascade" NARROW [] +synonym: "stimulation of JNK cascade" NARROW [] +synonym: "up regulation of JNK cascade" EXACT [] +synonym: "up-regulation of JNK cascade" EXACT [] +synonym: "upregulation of JNK cascade" EXACT [] +is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade +is_a: GO:0046328 ! regulation of JNK cascade +relationship: positively_regulates GO:0007254 ! JNK cascade + +[Term] +id: GO:0046331 +name: lateral inhibition +namespace: biological_process +def: "Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells." [GOC:bf, GOC:kmv] +is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment + +[Term] +id: GO:0046332 +name: SMAD binding +namespace: molecular_function +def: "Binding to a SMAD signaling protein." [GOC:ai] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046333 +name: octopamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] +synonym: "octopamine metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0042439 ! ethanolamine-containing compound metabolic process + +[Term] +id: GO:0046334 +name: octopamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] +synonym: "octopamine breakdown" EXACT [] +synonym: "octopamine catabolism" EXACT [] +synonym: "octopamine degradation" EXACT [] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042135 ! neurotransmitter catabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046333 ! octopamine metabolic process + +[Term] +id: GO:0046335 +name: ethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] +synonym: "ethanolamine anabolism" EXACT [] +synonym: "ethanolamine biosynthesis" EXACT [] +synonym: "ethanolamine formation" EXACT [] +synonym: "ethanolamine synthesis" EXACT [] +is_a: GO:0006580 ! ethanolamine metabolic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042401 ! cellular biogenic amine biosynthetic process +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:0046336 +name: ethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [GOC:ai] +synonym: "ethanolamine breakdown" EXACT [] +synonym: "ethanolamine catabolism" EXACT [] +synonym: "ethanolamine degradation" EXACT [] +is_a: GO:0006580 ! ethanolamine metabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0042402 ! cellular biogenic amine catabolic process +is_a: GO:1901161 ! primary amino compound catabolic process + +[Term] +id: GO:0046337 +name: phosphatidylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. It is a major structural phospholipid in mammalian systems. It tends to be more abundant than phosphatidylcholine in the internal membranes of the cell and is an abundant component of prokaryotic membranes." [GOC:curators, ISBN:0198506732] +synonym: "phosphatidylethanolamine metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046338 +name: phosphatidylethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] +synonym: "phosphatidylethanolamine breakdown" EXACT [] +synonym: "phosphatidylethanolamine catabolism" EXACT [] +synonym: "phosphatidylethanolamine degradation" EXACT [] +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0046339 +name: diacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11481335] +synonym: "diacylglycerol metabolism" EXACT [] +synonym: "diglyceride metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0046340 +name: diacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [PMID:11717312] +synonym: "diacylglycerol breakdown" EXACT [] +synonym: "diacylglycerol catabolism" EXACT [] +synonym: "diacylglycerol degradation" EXACT [] +synonym: "diglyceride catabolism" EXACT [] +is_a: GO:0046339 ! diacylglycerol metabolic process +is_a: GO:0046464 ! acylglycerol catabolic process + +[Term] +id: GO:0046341 +name: CDP-diacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate. It is a common intermediate in phospholipid biosynthesis." [PMID:24533860] +synonym: "CDP-diacylglycerol metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046342 +name: CDP-diacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [PMID:6147353] +synonym: "CDP-diacylglycerol breakdown" EXACT [] +synonym: "CDP-diacylglycerol catabolism" EXACT [] +synonym: "CDP-diacylglycerol degradation" EXACT [] +is_a: GO:0046341 ! CDP-diacylglycerol metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process + +[Term] +id: GO:0046343 +name: streptomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving streptomycin, a commonly used antibiotic in cell culture media. It acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [PMID:2111804] +synonym: "streptomycin metabolism" EXACT [] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:0046344 +name: ecdysteroid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development." [GOC:ai] +synonym: "ecdysteroid breakdown" EXACT [] +synonym: "ecdysteroid catabolism" EXACT [] +synonym: "ecdysteroid degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0042447 ! hormone catabolic process +is_a: GO:0045455 ! ecdysteroid metabolic process + +[Term] +id: GO:0046345 +name: abscisic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [GOC:ai] +synonym: "abscisic acid breakdown" EXACT [] +synonym: "abscisic acid catabolism" EXACT [] +synonym: "abscisic acid degradation" EXACT [] +is_a: GO:0009687 ! abscisic acid metabolic process +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0043290 ! apocarotenoid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process + +[Term] +id: GO:0046346 +name: mannosamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators] +synonym: "mannosamine breakdown" EXACT [] +synonym: "mannosamine catabolism" EXACT [] +synonym: "mannosamine degradation" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process +is_a: GO:0046348 ! amino sugar catabolic process + +[Term] +id: GO:0046347 +name: mannosamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [GOC:curators] +synonym: "mannosamine anabolism" EXACT [] +synonym: "mannosamine biosynthesis" EXACT [] +synonym: "mannosamine formation" EXACT [] +synonym: "mannosamine synthesis" EXACT [] +is_a: GO:0006050 ! mannosamine metabolic process +is_a: GO:0046349 ! amino sugar biosynthetic process + +[Term] +id: GO:0046348 +name: amino sugar catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators] +synonym: "amino sugar breakdown" EXACT [] +synonym: "amino sugar catabolism" EXACT [] +synonym: "amino sugar degradation" EXACT [] +synonym: "aminosaccharide catabolic process" EXACT [] +synonym: "aminosaccharide catabolism" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0046349 +name: amino sugar biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:curators] +synonym: "amino sugar anabolism" EXACT [] +synonym: "amino sugar biosynthesis" EXACT [] +synonym: "amino sugar formation" EXACT [] +synonym: "amino sugar synthesis" EXACT [] +synonym: "aminosaccharide biosynthesis" EXACT [] +synonym: "aminosaccharide biosynthetic process" EXACT [] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0046350 +name: galactosaminoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactosaminoglycans, any one of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] +synonym: "galactosaminoglycan metabolism" EXACT [] +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:0046351 +name: disaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] +synonym: "disaccharide anabolism" EXACT [] +synonym: "disaccharide biosynthesis" EXACT [] +synonym: "disaccharide formation" EXACT [] +synonym: "disaccharide synthesis" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process +is_a: GO:0009312 ! oligosaccharide biosynthetic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process + +[Term] +id: GO:0046352 +name: disaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units." [GOC:ai] +synonym: "disaccharide breakdown" EXACT [] +synonym: "disaccharide catabolism" EXACT [] +synonym: "disaccharide degradation" EXACT [] +is_a: GO:0005984 ! disaccharide metabolic process +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0046353 +name: aminoglycoside 3-N-acetyltransferase activity +namespace: molecular_function +alt_id: GO:0016991 +def: "Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring." [GOC:cb] +synonym: "3'-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] +synonym: "3-N-aminoglycoside acetyltransferase activity" RELATED [EC:2.3.1.81] +synonym: "acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity" RELATED [EC:2.3.1.81] +synonym: "acetyl-CoA:gentamicin-C N3'-acetyltransferase activity" NARROW [EC:2.3.1.60] +synonym: "aminoglycoside acetyltransferase AAC(3)-1" RELATED [EC:2.3.1.60] +synonym: "aminoglycoside acetyltransferase AAC(3)-I activity" RELATED [EC:2.3.1.60] +synonym: "gentamicin 3'-N-acetyltransferase activity" NARROW [] +synonym: "gentamicin acetyltransferase I activity" NARROW [EC:2.3.1.60] +synonym: "gentamicin-(3)-N-acetyltransferase activity" NARROW [EC:2.3.1.81] +synonym: "gentamycin 3'-N-acetyltransferase activity" EXACT [] +synonym: "gentamycin acetyltransferase I" RELATED [EC:2.3.1.60] +xref: EC:2.3.1.60 +xref: EC:2.3.1.81 +xref: MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN +xref: MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0046354 +name: mannan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732] +synonym: "mannan anabolism" EXACT [] +synonym: "mannan biosynthesis" EXACT [] +synonym: "mannan formation" EXACT [] +synonym: "mannan synthesis" EXACT [] +is_a: GO:0010412 ! mannan metabolic process +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0046355 +name: mannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose." [ISBN:0198506732] +synonym: "mannan breakdown" EXACT [] +synonym: "mannan catabolism" EXACT [] +synonym: "mannan degradation" EXACT [] +is_a: GO:0010412 ! mannan metabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0044347 ! cell wall polysaccharide catabolic process + +[Term] +id: GO:0046356 +name: acetyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:ai] +synonym: "acetyl-CoA breakdown" EXACT [] +synonym: "acetyl-CoA catabolism" EXACT [] +synonym: "acetyl-CoA degradation" EXACT [] +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:0046357 +name: galactarate biosynthetic process +namespace: biological_process +alt_id: GO:0042872 +def: "The chemical reactions and pathways resulting in the formation of galactarate, the anion of galactaric acid." [GOC:pr, ISBN:0198506732] +synonym: "D-galactarate anabolism" RELATED [] +synonym: "D-galactarate biosynthesis" RELATED [] +synonym: "D-galactarate biosynthetic process" RELATED [] +synonym: "D-galactarate formation" RELATED [] +synonym: "D-galactarate synthesis" RELATED [] +synonym: "galactarate anabolism" EXACT [] +synonym: "galactarate biosynthesis" EXACT [] +synonym: "galactarate formation" EXACT [] +synonym: "galactarate synthesis" EXACT [] +is_a: GO:0019578 ! aldaric acid biosynthetic process +is_a: GO:0019580 ! galactarate metabolic process + +[Term] +id: GO:0046358 +name: butyrate biosynthetic process +namespace: biological_process +alt_id: GO:0043439 +def: "The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid." [ISBN:0198506732] +synonym: "butanoic acid anabolism" EXACT [] +synonym: "butanoic acid biosynthesis" EXACT [] +synonym: "butanoic acid biosynthetic process" EXACT [] +synonym: "butanoic acid formation" EXACT [] +synonym: "butanoic acid synthesis" EXACT [] +synonym: "butyrate anabolism" EXACT [] +synonym: "butyrate biosynthesis" EXACT [] +synonym: "butyrate formation" EXACT [] +synonym: "butyrate synthesis" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0051790 ! short-chain fatty acid biosynthetic process + +[Term] +id: GO:0046359 +name: butyrate catabolic process +namespace: biological_process +alt_id: GO:0043440 +def: "The chemical reactions and pathways resulting in the breakdown of butyrate, the anion of butyric acid." [ISBN:0198506732] +synonym: "butanoic acid breakdown" EXACT [] +synonym: "butanoic acid catabolic process" EXACT [] +synonym: "butanoic acid catabolism" EXACT [] +synonym: "butanoic acid degradation" EXACT [] +synonym: "butyrate breakdown" EXACT [] +synonym: "butyrate catabolism" EXACT [] +synonym: "butyrate degradation" EXACT [] +is_a: GO:0019605 ! butyrate metabolic process +is_a: GO:0019626 ! short-chain fatty acid catabolic process + +[Term] +id: GO:0046360 +name: 2-oxobutyrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732] +synonym: "2-oxobutyrate anabolism" EXACT [] +synonym: "2-oxobutyrate biosynthesis" EXACT [] +synonym: "2-oxobutyrate formation" EXACT [] +synonym: "2-oxobutyrate synthesis" EXACT [] +synonym: "alpha-ketobutyrate biosynthesis" EXACT [] +synonym: "alpha-ketobutyrate biosynthetic process" EXACT [] +is_a: GO:0046361 ! 2-oxobutyrate metabolic process +is_a: GO:0051790 ! short-chain fatty acid biosynthetic process + +[Term] +id: GO:0046361 +name: 2-oxobutyrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [PMID:17034760] +synonym: "2-oxobutyrate metabolism" EXACT [] +synonym: "alpha-ketobutyrate metabolic process" EXACT [] +synonym: "alpha-ketobutyrate metabolism" EXACT [] +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0046362 +name: ribitol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732] +synonym: "ribitol anabolism" EXACT [] +synonym: "ribitol biosynthesis" EXACT [] +synonym: "ribitol formation" EXACT [] +synonym: "ribitol synthesis" EXACT [] +is_a: GO:0019349 ! ribitol metabolic process +is_a: GO:0019526 ! pentitol biosynthetic process + +[Term] +id: GO:0046363 +name: ribitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732] +synonym: "ribitol breakdown" EXACT [] +synonym: "ribitol catabolism" EXACT [] +synonym: "ribitol degradation" EXACT [] +is_a: GO:0019349 ! ribitol metabolic process +is_a: GO:0019527 ! pentitol catabolic process + +[Term] +id: GO:0046364 +name: monosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] +synonym: "monosaccharide anabolism" EXACT [] +synonym: "monosaccharide biosynthesis" EXACT [] +synonym: "monosaccharide formation" EXACT [] +synonym: "monosaccharide synthesis" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0016051 ! carbohydrate biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process + +[Term] +id: GO:0046365 +name: monosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms." [ISBN:0198506732] +synonym: "monosaccharide breakdown" EXACT [] +synonym: "monosaccharide catabolism" EXACT [] +synonym: "monosaccharide degradation" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0016052 ! carbohydrate catabolic process +is_a: GO:0044282 ! small molecule catabolic process + +[Term] +id: GO:0046366 +name: allose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] +synonym: "allose anabolism" EXACT [] +synonym: "allose biosynthesis" EXACT [] +synonym: "allose formation" EXACT [] +synonym: "allose synthesis" EXACT [] +is_a: GO:0019313 ! allose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046367 +name: allose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] +synonym: "allose breakdown" EXACT [] +synonym: "allose catabolism" EXACT [] +synonym: "allose degradation" EXACT [] +is_a: GO:0019313 ! allose metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:0046368 +name: GDP-L-fucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-L-fucose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046369 +name: galactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactose, the aldohexose galacto-hexose." [ISBN:0198506732] +synonym: "galactose anabolism" EXACT [] +synonym: "galactose biosynthesis" EXACT [] +synonym: "galactose formation" EXACT [] +synonym: "galactose synthesis" EXACT [] +is_a: GO:0006012 ! galactose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046370 +name: fructose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] +synonym: "fructose anabolism" EXACT [] +synonym: "fructose biosynthesis" EXACT [] +synonym: "fructose formation" EXACT [] +synonym: "fructose synthesis" EXACT [] +is_a: GO:0006000 ! fructose metabolic process +is_a: GO:0019319 ! hexose biosynthetic process + +[Term] +id: GO:0046371 +name: dTDP-mannose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +synonym: "dTDP-mannose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046372 +name: D-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arabinose, the D-enantiomer of arabino-pentose. D-arabinose occurs in plant glycosides and is a constituent of arabinonucleosides." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-arabinose metabolism" EXACT [] +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0046373 +name: L-arabinose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-arabinose metabolism" EXACT [] +is_a: GO:0019566 ! arabinose metabolic process + +[Term] +id: GO:0046374 +name: teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732] +synonym: "teichoic acid metabolism" EXACT [] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0046375 +name: K antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732] +synonym: "K antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0046376 +name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [ISBN:0198506732] +synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:0006721 ! terpenoid metabolic process + +[Term] +id: GO:0046377 +name: colanic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues." [GOC:ai, http://www.science.siu.edu/microbiology/micr425/425Notes/02-CellEnv.html] +synonym: "colanic acid metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0046378 +name: enterobacterial common antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] +synonym: "enterobacterial common antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0046379 +name: extracellular polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai] +synonym: "extracellular polysaccharide metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046380 +name: N-acetylneuraminate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] +synonym: "N-acetylneuraminate anabolism" EXACT [] +synonym: "N-acetylneuraminate biosynthesis" EXACT [] +synonym: "N-acetylneuraminate formation" EXACT [] +synonym: "N-acetylneuraminate synthesis" EXACT [] +is_a: GO:0006054 ! N-acetylneuraminate metabolic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0046349 ! amino sugar biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0046381 +name: CMP-N-acetylneuraminate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] +synonym: "CMP-N-acetylneuraminate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046382 +name: GDP-D-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "GDP-D-rhamnose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046383 +name: dTDP-rhamnose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] +synonym: "dTDP-rhamnose metabolism" EXACT [] +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0046384 +name: 2-deoxyribose 1-phosphate metabolic process +namespace: biological_process +alt_id: GO:0046388 +def: "The chemical reactions and pathways involving 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732] +synonym: "2-deoxyribose 1-phosphate metabolism" EXACT [] +synonym: "deoxyribose 1-phosphate metabolic process" EXACT [] +synonym: "deoxyribose 1-phosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046385 +name: deoxyribose phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] +synonym: "deoxyribose phosphate anabolism" EXACT [] +synonym: "deoxyribose phosphate biosynthesis" EXACT [] +synonym: "deoxyribose phosphate formation" EXACT [] +synonym: "deoxyribose phosphate synthesis" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0046386 +name: deoxyribose phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] +synonym: "deoxyribose phosphate breakdown" EXACT [] +synonym: "deoxyribose phosphate catabolism" EXACT [] +synonym: "deoxyribose phosphate degradation" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0046387 +name: deoxyribose 1,5-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] +synonym: "deoxyribose 1,5-bisphosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046389 +name: deoxyribose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose." [GOC:ai] +synonym: "deoxyribose 5-phosphate metabolism" EXACT [] +is_a: GO:0019692 ! deoxyribose phosphate metabolic process + +[Term] +id: GO:0046390 +name: ribose phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] +synonym: "ribose phosphate anabolism" EXACT [] +synonym: "ribose phosphate biosynthesis" EXACT [] +synonym: "ribose phosphate formation" EXACT [] +synonym: "ribose phosphate synthesis" EXACT [] +is_a: GO:0019693 ! ribose phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0046391 +name: 5-phosphoribose 1-diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] +synonym: "5-phosphoribose 1-diphosphate metabolism" EXACT [] +synonym: "PRPP metabolic process" EXACT [] +xref: MetaCyc:PRPP-PWY +is_a: GO:0019693 ! ribose phosphate metabolic process + +[Term] +id: GO:0046392 +name: galactarate catabolic process +namespace: biological_process +alt_id: GO:0019582 +def: "The chemical reactions and pathways resulting in the breakdown of galactarate, the anion of galactaric acid." [GOC:ai, GOC:pr] +synonym: "D-galactarate breakdown" RELATED [] +synonym: "D-galactarate catabolic process" RELATED [] +synonym: "D-galactarate catabolism" RELATED [] +synonym: "D-galactarate degradation" RELATED [] +synonym: "galactarate breakdown" EXACT [] +synonym: "galactarate catabolism" EXACT [] +synonym: "galactarate degradation" EXACT [] +xref: MetaCyc:GALACTARDEG-PWY +is_a: GO:0019579 ! aldaric acid catabolic process +is_a: GO:0019580 ! galactarate metabolic process + +[Term] +id: GO:0046394 +name: carboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "carboxylic acid anabolism" EXACT [] +synonym: "carboxylic acid biosynthesis" EXACT [] +synonym: "carboxylic acid formation" EXACT [] +synonym: "carboxylic acid synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046395 +name: carboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] +synonym: "carboxylic acid breakdown" EXACT [] +synonym: "carboxylic acid catabolism" EXACT [] +synonym: "carboxylic acid degradation" EXACT [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046396 +name: D-galacturonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. D-galacturonic acid is a component of plant gums and bacterial cell walls." [GOC:ai, GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "D-galacturonate metabolism" EXACT [] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0019586 ! galacturonate metabolic process + +[Term] +id: GO:0046397 +name: galacturonate catabolic process +namespace: biological_process +alt_id: GO:0019587 +def: "The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid." [GOC:ai] +synonym: "galacturonate breakdown" EXACT [] +synonym: "galacturonate catabolism" EXACT [] +synonym: "galacturonate degradation" EXACT [] +is_a: GO:0019586 ! galacturonate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process + +[Term] +id: GO:0046398 +name: UDP-glucuronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] +synonym: "UDP-glucuronate metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046399 +name: glucuronate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucuronate, the anion of glucuronic acid." [GOC:ai] +synonym: "glucuronate anabolism" EXACT [] +synonym: "glucuronate biosynthesis" EXACT [] +synonym: "glucuronate formation" EXACT [] +synonym: "glucuronate synthesis" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:0046400 +name: keto-3-deoxy-D-manno-octulosonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [GOC:ai, ISBN:0198506732] +synonym: "KDO metabolic process" EXACT [GOC:mah] +synonym: "KDO metabolism" EXACT [GOC:mah] +synonym: "keto-3-deoxy-D-manno-octulosonic acid metabolism" EXACT [] +synonym: "ketodeoxyoctanoate metabolic process" RELATED [ISBN:0198506732] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046401 +name: lipopolysaccharide core region metabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains." [ISBN:0198506732] +synonym: "lipopolysaccharide core region metabolism" EXACT [] +synonym: "LPS core region metabolic process" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +relationship: part_of GO:0008653 ! lipopolysaccharide metabolic process + +[Term] +id: GO:0046402 +name: O antigen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732] +synonym: "O antigen metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0046403 +name: polynucleotide 3'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] +synonym: "2'(3')-polynucleotidase activity" RELATED [EC:3.1.3.32] +synonym: "5'-polynucleotidekinase 3'-phosphatase activity" RELATED [EC:3.1.3.32] +synonym: "deoxyribonucleate 3'-phosphatase activity" RELATED [EC:3.1.3.32] +synonym: "DNA 3'-phosphatase activity" RELATED [EC:3.1.3.32] +synonym: "polynucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.3.32] +xref: EC:3.1.3.32 +xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN +xref: Reactome:R-HSA-5649705 "PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB)" +xref: RHEA:14113 +is_a: GO:0098518 ! polynucleotide phosphatase activity + +[Term] +id: GO:0046404 +name: polydeoxyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA." [RHEA:15669] +synonym: "ATP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP-dependent DNA kinase activity" EXACT [] +synonym: "ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity" RELATED [] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] +xref: EC:2.7.1.78 +xref: KEGG_REACTION:R03840 +xref: MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN +xref: RHEA:15669 +is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity +is_a: GO:0051734 ! polynucleotide kinase activity + +[Term] +id: GO:0046405 +name: glycerol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O." [EC:4.2.1.30, PMID:18307109] +synonym: "glycerol dehydrase activity" RELATED [EC:4.2.1.30] +synonym: "glycerol hydro-lyase (3-hydroxypropanal-forming)" RELATED [EC:4.2.1.30] +synonym: "glycerol hydro-lyase activity" RELATED [EC:4.2.1.30] +xref: EC:4.2.1.30 +xref: MetaCyc:GLYCEROL-DEHYDRATASE-RXN +xref: RHEA:19765 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046406 +name: magnesium protoporphyrin IX methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester." [EC:2.1.1.11, RHEA:17809] +synonym: "(-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "magnesium-protoporphyrin O-methyltransferase activity" EXACT [] +synonym: "Mg-protoporphyrin IX methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11] +synonym: "S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity" RELATED [EC:2.1.1.11] +xref: EC:2.1.1.11 +xref: KEGG_REACTION:R04237 +xref: MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN +xref: RHEA:17809 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046408 +name: chlorophyll synthetase activity +namespace: molecular_function +alt_id: GO:0043787 +def: "Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate." [EC:2.5.1.62, RHEA:17317] +synonym: "chlorophyll synthase activity" EXACT [] +synonym: "chlorophyllide-a:phytyl-diphosphate phytyltransferase activity" EXACT [] +xref: EC:2.5.1.62 +xref: KEGG_REACTION:R06284 +xref: MetaCyc:RXN1F-66 +xref: RHEA:17317 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0046409 +name: p-coumarate 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+." [PMID:11429408, PMID:11891223] +synonym: "cytochrome P450 CYP98A3" NARROW [] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0046410 +name: obsolete 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 2-oxoglutarate + isochorismate = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate + CO2." [EC:2.5.1.64, PMID:1459959] +comment: This term was made obsolete because it was derived from an EC entry (EC:2.5.1.64) that has since been split into two entries. +synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity" EXACT [] +is_obsolete: true +consider: GO:0070204 +consider: GO:0070205 + +[Term] +id: GO:0046411 +name: 2-keto-3-deoxygluconate transmembrane transport +namespace: biological_process +def: "The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators] +synonym: "2-keto-3-deoxygluconate transport" RELATED [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015749 ! monosaccharide transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0046412 +name: phenylmercury acetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] +synonym: "phenylmercury acetate metabolism" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0046413 +name: organomercury catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] +synonym: "organomercury breakdown" EXACT [] +synonym: "organomercury catabolism" EXACT [] +synonym: "organomercury degradation" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046414 +name: organomercury biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom." [GOC:ai] +synonym: "organomercury anabolism" EXACT [] +synonym: "organomercury biosynthesis" EXACT [] +synonym: "organomercury formation" EXACT [] +synonym: "organomercury synthesis" EXACT [] +is_a: GO:0018941 ! organomercury metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0046415 +name: urate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [ISBN:0198506732] +synonym: "urate metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0046416 +name: D-amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] +synonym: "D-amino acid metabolism" EXACT [] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0046417 +name: chorismate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid." [ISBN:0198506732] +synonym: "chorismate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046418 +name: nopaline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nopaline, (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:ai] +synonym: "nopaline metabolism" EXACT [] +is_a: GO:0006520 ! cellular amino acid metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process + +[Term] +id: GO:0046419 +name: octopine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:ai] +synonym: "octopine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046421 +name: methylisocitrate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate." [EC:4.1.3.30, RHEA:16809] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)" RELATED [EC:4.1.3.30] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity" RELATED [EC:4.1.3.30] +synonym: "2-methylisocitrate lyase activity" EXACT [] +synonym: "MICL" RELATED [EC:4.1.3.30] +xref: EC:4.1.3.30 +xref: KEGG_REACTION:R00409 +xref: MetaCyc:METHYLISOCITRATE-LYASE-RXN +xref: RHEA:16809 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0046422 +name: violaxanthin de-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O." [EC:1.23.5.1, GOC:ai, ISBN:0471331309] +synonym: "VDE" RELATED [EC:1.23.5.1] +synonym: "violaxanthin:ascorbate oxidoreductase activity" RELATED [EC:1.23.5.1] +xref: EC:1.23.5.1 +xref: RHEA:32371 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0046423 +name: allene-oxide cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate." [EC:5.3.99.6, RHEA:22592] +synonym: "(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing)" RELATED [EC:5.3.99.6] +xref: EC:5.3.99.6 +xref: KEGG_REACTION:R03402 +xref: MetaCyc:ALLENE-OXIDE-CYCLASE-RXN +xref: RHEA:22592 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0046424 +name: ferulate 5-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+." [PMID:8692910, PMID:9880351] +xref: MetaCyc:RXN-1121 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0046425 +name: regulation of receptor signaling pathway via JAK-STAT +namespace: biological_process +alt_id: GO:0007262 +alt_id: GO:2000364 +def: "Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT." [GOC:bf] +synonym: "regulation of STAT protein import into nucleus" NARROW [] +synonym: "regulation of STAT protein nuclear translocation" NARROW [GOC:obol] +synonym: "STAT protein import into nucleus" NARROW [] +is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT +relationship: regulates GO:0007259 ! receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0046426 +name: negative regulation of receptor signaling pathway via JAK-STAT +namespace: biological_process +alt_id: GO:2000365 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT." [GOC:bf] +synonym: "down regulation of JAK-STAT cascade" EXACT [] +synonym: "down-regulation of JAK-STAT cascade" EXACT [] +synonym: "downregulation of JAK-STAT cascade" EXACT [] +synonym: "inhibition of JAK-STAT cascade" NARROW [] +synonym: "negative regulation of STAT protein import into nucleus" NARROW [] +synonym: "negative regulation of STAT protein nuclear translocation" NARROW [GOC:obol] +is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT +is_a: GO:1904893 ! negative regulation of receptor signaling pathway via STAT +relationship: negatively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0046427 +name: positive regulation of receptor signaling pathway via JAK-STAT +namespace: biological_process +alt_id: GO:2000366 +def: "Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity." [GOC:bf] +synonym: "activation of JAK-STAT cascade" NARROW [] +synonym: "positive regulation of STAT protein import into nucleus" NARROW [] +synonym: "positive regulation of STAT protein nuclear translocation" NARROW [GOC:obol] +synonym: "stimulation of JAK-STAT cascade" NARROW [] +synonym: "up regulation of JAK-STAT cascade" EXACT [] +synonym: "up-regulation of JAK-STAT cascade" EXACT [] +synonym: "upregulation of JAK-STAT cascade" EXACT [] +is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT +is_a: GO:1904894 ! positive regulation of receptor signaling pathway via STAT +relationship: positively_regulates GO:0007259 ! receptor signaling pathway via JAK-STAT + +[Term] +id: GO:0046428 +name: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2." [RHEA:30099] +synonym: "1,4-Dihydroxy-2-naphtoate prenyltransferase activity" EXACT [] +xref: EC:2.5.1.74 +xref: MetaCyc:DMK-RXN +xref: RHEA:30099 +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0046429 +name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin." [EC:1.17.7.1, PMID:11752431] +synonym: "(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity" EXACT systematic_synonym [EC:1.17.7.1] +synonym: "(E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity" RELATED [EC:1.17.7.1] +synonym: "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] +synonym: "1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity" EXACT [MetaCyc:HYDROXY-METHYL-BUTENYL-DIP] +xref: EC:1.17.7.1 +xref: KEGG_REACTION:R08689 +xref: MetaCyc:RXN0-882 +xref: RHEA:26119 +is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor + +[Term] +id: GO:0046430 +name: non-phosphorylated glucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving non-phosphorylated forms of glucose." [GOC:ai] +synonym: "non-phosphorylated glucose metabolism" EXACT [] +is_a: GO:0006006 ! glucose metabolic process + +[Term] +id: GO:0046431 +name: (R)-4-hydroxymandelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (R)-4-hydroxymandelate, the anion of a hydroxylated derivative of mandelate (alpha-hydroxybenzeneacetate)." [GOC:ai, ISBN:0198506732] +synonym: "(R)-4-hydroxymandelate metabolism" EXACT [] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0046432 +name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process + +[Term] +id: GO:0046433 +name: 2-aminoethylphosphonate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-aminoethylphosphonate, most abundant and ubiquitous of naturally occurring phosphonates. It is typically found as a conjugate of glycans, lipids, and proteins, which in turn perform essential biochemical functions in specialized lower organisms." [GOC:ai, PMID:12107130] +synonym: "2-aminoethylphosphonate metabolism" EXACT [] +synonym: "2-phosphonoethylamine metabolic process" EXACT [] +synonym: "2-phosphonoethylamine metabolism" EXACT [] +synonym: "ciliatine metabolic process" EXACT [] +synonym: "ciliatine metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0046434 +name: organophosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organophosphates, any phosphate-containing organic compound." [GOC:ai] +synonym: "organophosphate breakdown" EXACT [] +synonym: "organophosphate catabolism" EXACT [] +synonym: "organophosphate degradation" EXACT [] +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046435 +name: 3-(3-hydroxy)phenylpropionate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] +synonym: "3-(3-hydroxy)phenylpropionate metabolism" EXACT [] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0046436 +name: D-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid." [GOC:ai, GOC:jsg] +synonym: "D-alanine metabolism" EXACT [] +is_a: GO:0046144 ! D-alanine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046437 +name: D-amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] +synonym: "D-amino acid anabolism" EXACT [] +synonym: "D-amino acid biosynthesis" EXACT [] +synonym: "D-amino acid formation" EXACT [] +synonym: "D-amino acid synthesis" EXACT [] +is_a: GO:0046416 ! D-amino acid metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0046438 +name: D-cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:ai] +synonym: "D-cysteine metabolism" EXACT [] +is_a: GO:0006534 ! cysteine metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046439 +name: L-cysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "L-cysteine metabolism" EXACT [] +is_a: GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:0046440 +name: L-lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid, i.e. (2S)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "L-lysine metabolism" EXACT [] +is_a: GO:0006553 ! lysine metabolic process + +[Term] +id: GO:0046441 +name: D-lysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "D-lysine metabolism" EXACT [] +is_a: GO:0006553 ! lysine metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0046442 +name: aerobactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] +synonym: "aerobactin metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process + +[Term] +id: GO:0046443 +name: FAD metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving FAD, the oxidized form of flavin adenine dinucleotide." [PMID:20822113] +synonym: "FAD metabolism" EXACT [] +synonym: "oxidized flavin adenine dinucleotide metabolic process" EXACT [] +synonym: "oxidized flavin adenine dinucleotide metabolism" EXACT [] +synonym: "oxidized flavin-adenine dinucleotide metabolic process" EXACT [] +synonym: "oxidized flavin-adenine dinucleotide metabolism" EXACT [] +is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process + +[Term] +id: GO:0046444 +name: FMN metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, PMID:20822113] +synonym: "FMN metabolism" EXACT [] +is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process +is_a: GO:0009259 ! ribonucleotide metabolic process +is_a: GO:0042726 ! flavin-containing compound metabolic process + +[Term] +id: GO:0046445 +name: benzyl isoquinoline alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732] +synonym: "benzyl isoquinoline alkaloid metabolism" EXACT [] +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process + +[Term] +id: GO:0046446 +name: purine alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] +synonym: "purine alkaloid metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process + +[Term] +id: GO:0046447 +name: terpenoid indole alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] +synonym: "terpenoid indole alkaloid metabolism" EXACT [] +is_a: GO:0035834 ! indole alkaloid metabolic process + +[Term] +id: GO:0046448 +name: tropane alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732] +synonym: "tropane alkaloid metabolism" EXACT [] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0046449 +name: creatinine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732] +synonym: "creatinine metabolism" EXACT [] +is_a: GO:0072338 ! cellular lactam metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0046450 +name: dethiobiotin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dethiobiotin, a derivative of biotin formed by replacing the sulfur atom by two hydrogen atoms." [ISBN:0198506732] +synonym: "desthiobiotin metabolic process" EXACT [] +synonym: "desthiobiotin metabolism" EXACT [] +synonym: "dethiobiotin metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0046451 +name: diaminopimelate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ai, ISBN:0198506732] +synonym: "diaminopimelate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046452 +name: dihydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate." [ISBN:0198506732] +synonym: "dihydrofolate metabolism" EXACT [] +synonym: "dihydrofolate reduction" NARROW [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046453 +name: dipyrrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] +synonym: "dipyrrin metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0046454 +name: dimethylsilanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:ai] +synonym: "dimethylsilanediol metabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0046455 +name: organosilicon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon." [GOC:ai] +synonym: "organosilicon breakdown" EXACT [] +synonym: "organosilicon catabolism" EXACT [] +synonym: "organosilicon degradation" EXACT [] +synonym: "organosilicone catabolic process" EXACT [] +synonym: "organosilicone catabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0046456 +name: icosanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of icosanoids, any of a group of C20 polyunsaturated fatty acids." [ISBN:0198506732] +synonym: "eicosanoid biosynthesis" EXACT [] +synonym: "eicosanoid biosynthetic process" EXACT [] +synonym: "eoxin biosynthesis" EXACT [] +synonym: "eoxin synthesis" EXACT [] +synonym: "icosanoid anabolism" EXACT [] +synonym: "icosanoid biosynthesis" EXACT [] +synonym: "icosanoid formation" EXACT [] +synonym: "icosanoid synthesis" EXACT [] +xref: Wikipedia:Eicosanoid +is_a: GO:0006690 ! icosanoid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0046457 +name: prostanoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." [GOC:ai] +synonym: "prostanoid anabolism" EXACT [] +synonym: "prostanoid biosynthesis" EXACT [] +synonym: "prostanoid formation" EXACT [] +synonym: "prostanoid synthesis" EXACT [] +xref: Wikipedia:Prostanoid#Biosynthesis +is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process +is_a: GO:0006692 ! prostanoid metabolic process +is_a: GO:0046456 ! icosanoid biosynthetic process + +[Term] +id: GO:0046458 +name: hexadecanal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde." [PMID:25047030] +synonym: "hexadecanal metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:0046459 +name: short-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acids with a chain length of less than C6." [Wikipedia:Fatty_acid_metabolism] +synonym: "short-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0046460 +name: neutral lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] +synonym: "neutral lipid anabolism" EXACT [] +synonym: "neutral lipid biosynthesis" EXACT [] +synonym: "neutral lipid formation" EXACT [] +synonym: "neutral lipid synthesis" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046461 +name: neutral lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] +synonym: "neutral lipid breakdown" EXACT [] +synonym: "neutral lipid catabolism" EXACT [] +synonym: "neutral lipid degradation" EXACT [] +is_a: GO:0006638 ! neutral lipid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0046462 +name: monoacylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732] +synonym: "monoacylglycerol metabolism" EXACT [] +synonym: "monoglyceride metabolic process" EXACT [] +synonym: "monoglyceride metabolism" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process + +[Term] +id: GO:0046463 +name: acylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] +synonym: "acylglycerol anabolism" EXACT [] +synonym: "acylglycerol biosynthesis" EXACT [] +synonym: "acylglycerol formation" EXACT [] +synonym: "acylglycerol synthesis" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process +is_a: GO:0045017 ! glycerolipid biosynthetic process +is_a: GO:0046460 ! neutral lipid biosynthetic process + +[Term] +id: GO:0046464 +name: acylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] +synonym: "acylglycerol breakdown" EXACT [] +synonym: "acylglycerol catabolism" EXACT [] +synonym: "acylglycerol degradation" EXACT [] +is_a: GO:0006639 ! acylglycerol metabolic process +is_a: GO:0046461 ! neutral lipid catabolic process +is_a: GO:0046503 ! glycerolipid catabolic process + +[Term] +id: GO:0046465 +name: dolichyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dolichyl diphosphate, a diphosphorylated dolichol derivative. In eukaryotes, these function as carriers of mono- and oligosaccharide residues in the glycosylation of lipids and proteins within intracellular membranes." [ISBN:0198506732] +synonym: "dolichyl diphosphate metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:0046466 +name: membrane lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +synonym: "membrane lipid breakdown" EXACT [] +synonym: "membrane lipid catabolism" EXACT [] +synonym: "membrane lipid degradation" EXACT [] +synonym: "membrane lipid peroxidation" BROAD [GOC:tb] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0046467 +name: membrane lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] +synonym: "membrane lipid anabolism" EXACT [] +synonym: "membrane lipid biosynthesis" EXACT [] +synonym: "membrane lipid formation" EXACT [] +synonym: "membrane lipid synthesis" EXACT [] +is_a: GO:0006643 ! membrane lipid metabolic process +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044249 ! cellular biosynthetic process + +[Term] +id: GO:0046468 +name: phosphatidyl-N-monomethylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group. Present in trace levels in plants and slightly higher in bacteria." [http://www.lipid.co.uk] +synonym: "phosphatidyl-N-monomethylethanolamine metabolism" EXACT [] +synonym: "PMME metabolic process" EXACT [] +synonym: "PMME metabolism" EXACT [] +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0046469 +name: platelet activating factor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] +synonym: "PAF metabolic process" EXACT [] +synonym: "PAF metabolism" EXACT [] +synonym: "platelet activating factor metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0046485 ! ether lipid metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0046470 +name: phosphatidylcholine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes." [ISBN:0198506732] +synonym: "phosphatidylcholine metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0046471 +name: phosphatidylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes." [ISBN:0198506732] +synonym: "phosphatidylglycerol metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046473 +name: phosphatidic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732] +synonym: "phosphatidic acid metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046474 +name: glycerophospholipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] +synonym: "glycerophospholipid anabolism" EXACT [] +synonym: "glycerophospholipid biosynthesis" EXACT [] +synonym: "glycerophospholipid formation" EXACT [] +synonym: "glycerophospholipid synthesis" EXACT [] +synonym: "phosphoglyceride biosynthesis" EXACT [] +synonym: "phosphoglyceride biosynthetic process" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0045017 ! glycerolipid biosynthetic process + +[Term] +id: GO:0046475 +name: glycerophospholipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] +synonym: "glycerophospholipid breakdown" EXACT [] +synonym: "glycerophospholipid catabolism" EXACT [] +synonym: "glycerophospholipid degradation" EXACT [] +synonym: "phosphoglyceride catabolic process" EXACT [] +synonym: "phosphoglyceride catabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0046503 ! glycerolipid catabolic process + +[Term] +id: GO:0046476 +name: glycosylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] +synonym: "glycosylceramide anabolism" EXACT [] +synonym: "glycosylceramide biosynthesis" EXACT [] +synonym: "glycosylceramide formation" EXACT [] +synonym: "glycosylceramide synthesis" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:0046477 +name: glycosylceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai] +synonym: "glycosylceramide breakdown" EXACT [] +synonym: "glycosylceramide catabolism" EXACT [] +synonym: "glycosylceramide degradation" EXACT [] +is_a: GO:0006677 ! glycosylceramide metabolic process +is_a: GO:0046479 ! glycosphingolipid catabolic process +is_a: GO:0046514 ! ceramide catabolic process + +[Term] +id: GO:0046478 +name: lactosylceramide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732] +synonym: "lactosylceramide metabolism" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0006687 ! glycosphingolipid metabolic process + +[Term] +id: GO:0046479 +name: glycosphingolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198506732] +synonym: "glycosphingolipid breakdown" EXACT [] +synonym: "glycosphingolipid catabolism" EXACT [] +synonym: "glycosphingolipid degradation" EXACT [] +is_a: GO:0006687 ! glycosphingolipid metabolic process +is_a: GO:0019377 ! glycolipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0046480 +name: galactolipid galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol." [EC:2.4.1.184] +synonym: "3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.184] +synonym: "DGDG synthase activity" BROAD [EC:2.4.1.184] +synonym: "digalactosyldiacylglycerol synthase activity" BROAD [EC:2.4.1.184] +synonym: "galactolipid-galactolipid galactosyltransferase activity" RELATED [EC:2.4.1.184] +synonym: "galactolipid:galactolipid galactosyltransferase activity" EXACT [] +synonym: "GGGT activity" RELATED [EC:2.4.1.184] +synonym: "interlipid galactosyltransferase activity" RELATED [EC:2.4.1.184] +xref: EC:2.4.1.184 +xref: MetaCyc:RXN-1226 +xref: RHEA:15921 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0046481 +name: digalactosyldiacylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.241, RHEA:10520] +synonym: "DGD1" NARROW [] +synonym: "DGD2" NARROW [] +synonym: "DGDG synthase activity" BROAD [EC:2.4.1.241] +synonym: "UDP-galactose-dependent DGDG synthase activity" RELATED [EC:2.4.1.241] +synonym: "UDP-galactose-dependent digalactosyldiacylglycerol synthase activity" RELATED [EC:2.4.1.241] +synonym: "UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.241] +synonym: "UDP-galactose:MGDG galactosyltransferase activity" EXACT [] +xref: EC:2.4.1.241 +xref: KEGG_REACTION:R04469 +xref: MetaCyc:RXN-1225 +xref: RHEA:10520 +xref: Wikipedia:Digalactosyldiacylglycerol_synthase +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0046482 +name: para-aminobenzoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, PMID:11377864, PMID:11960743] +synonym: "4-aminobenzoic acid metabolic process" EXACT [] +synonym: "4-aminobenzoic acid metabolism" EXACT [] +synonym: "p-aminobenzoic acid metabolic process" EXACT [] +synonym: "p-aminobenzoic acid metabolism" EXACT [] +synonym: "PABA metabolic process" EXACT [] +synonym: "PABA metabolism" EXACT [] +synonym: "para-aminobenzoic acid metabolism" EXACT [] +synonym: "vitamin Bx metabolic process" EXACT [] +synonym: "vitamin Bx metabolism" EXACT [] +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0046483 +name: heterocycle metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198506732] +subset: goslim_pir +synonym: "heterocycle metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0046484 +name: oxazole or thiazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [GOC:curators] +synonym: "oxazole or thiazole metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046485 +name: ether lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [ISBN:0198506732, PMID:15337120] +synonym: "ether lipid metabolism" EXACT [] +synonym: "plasmalogen metabolic process" NARROW [] +xref: Wikipedia:Ether_lipid +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046486 +name: glycerolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569] +synonym: "glycerolipid metabolism" EXACT [] +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046487 +name: glyoxylate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] +synonym: "glyoxylate metabolism" EXACT [] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0046488 +name: phosphatidylinositol metabolic process +namespace: biological_process +alt_id: GO:0030384 +def: "The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] +synonym: "phosphatidylinositol metabolism" EXACT [] +synonym: "phosphoinositide metabolic process" EXACT [] +synonym: "phosphoinositide metabolism" EXACT [] +synonym: "PtdIns metabolic process" EXACT [] +synonym: "PtdIns metabolism" EXACT [] +is_a: GO:0006650 ! glycerophospholipid metabolic process + +[Term] +id: GO:0046490 +name: isopentenyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [ISBN:0198506732] +subset: goslim_pir +synonym: "IPP metabolic process" EXACT [] +synonym: "IPP metabolism" EXACT [] +synonym: "isopentenyl diphosphate metabolism" EXACT [] +synonym: "isopentenyl pyrophosphate metabolic process" EXACT [] +synonym: "isopentenyl pyrophosphate metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:0046491 +name: L-methylmalonyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA. S-methylmalonyl-CoA is an intermediate in the beta oxidation of odd-numbered fatty acids in animals." [GOC:jsg, GOC:mah, ISBN:0198506732] +synonym: "L-methylmalonyl-CoA metabolism" EXACT [] +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:0046492 +name: heme B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, PMID:29414780] +synonym: "haem B metabolic process" EXACT [] +synonym: "haem B metabolism" EXACT [] +synonym: "heme B metabolism" EXACT [] +synonym: "protoheme metabolic process" EXACT [] +synonym: "protoheme metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0046493 +name: lipid A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004] +synonym: "lipid A metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:1901269 ! lipooligosaccharide metabolic process + +[Term] +id: GO:0046494 +name: rhizobactin 1021 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] +synonym: "rhizobactin 1021 metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0009237 ! siderophore metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:0046495 +name: nicotinamide riboside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] +synonym: "N-ribosylnicotinamide metabolic process" EXACT [] +synonym: "nicotinamide riboside metabolism" EXACT [] +is_a: GO:0070637 ! pyridine nucleoside metabolic process + +[Term] +id: GO:0046496 +name: nicotinamide nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [ISBN:0198506732] +synonym: "nicotinamide nucleotide metabolism" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0046497 +name: nicotinate nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid, or niacin)." [ISBN:0198506732] +synonym: "nicotinate nucleotide metabolism" EXACT [] +is_a: GO:0019362 ! pyridine nucleotide metabolic process + +[Term] +id: GO:0046498 +name: S-adenosylhomocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine." [ISBN:0198506732] +synonym: "S-adenosylhomocysteine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0046499 +name: S-adenosylmethioninamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] +synonym: "S-adenosylmethioninamine metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:0046500 +name: S-adenosylmethionine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] +synonym: "S-adenosyl methionine metabolic process" EXACT [] +synonym: "S-adenosyl methionine metabolism" EXACT [] +synonym: "S-adenosylmethionine metabolism" EXACT [] +synonym: "SAM metabolic process" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0046501 +name: protoporphyrinogen IX metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving protoporphyrinogen IX, the specific substrate for the enzyme ferrochelatase, which catalyzes the insertion of iron to form protoheme. It is probably also the substrate for chlorophyll formation." [ISBN:0198506732] +comment: See also the molecular function term 'ferrochelatase activity ; GO:0004325'. +synonym: "protoporphyrinogen IX metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process + +[Term] +id: GO:0046502 +name: uroporphyrinogen III metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving uroporphyrinogen III, a precursor for synthesis of vitamin B12, chlorophyll, and heme in organisms that produce these compounds." [GOC:ai] +synonym: "uroporphyrinogen III metabolism" EXACT [] +is_a: GO:0006778 ! porphyrin-containing compound metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046503 +name: glycerolipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] +synonym: "glycerolipid breakdown" EXACT [] +synonym: "glycerolipid catabolism" EXACT [] +synonym: "glycerolipid degradation" EXACT [] +is_a: GO:0044242 ! cellular lipid catabolic process +is_a: GO:0046486 ! glycerolipid metabolic process + +[Term] +id: GO:0046504 +name: glycerol ether biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai] +synonym: "glycerol ether anabolism" EXACT [] +synonym: "glycerol ether biosynthesis" EXACT [] +synonym: "glycerol ether formation" EXACT [] +synonym: "glycerol ether synthesis" EXACT [] +is_a: GO:0006662 ! glycerol ether metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0046505 +name: sulfolipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] +synonym: "sulfolipid metabolism" EXACT [] +synonym: "sulpholipid metabolic process" EXACT [] +synonym: "sulpholipid metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0046506 +name: sulfolipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sulfolipid, a compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid." [PMID:9751667] +synonym: "sulfolipid anabolism" EXACT [] +synonym: "sulfolipid biosynthesis" EXACT [] +synonym: "sulfolipid formation" EXACT [] +synonym: "sulfolipid synthesis" EXACT [] +synonym: "sulpholipid biosynthesis" EXACT [] +synonym: "sulpholipid biosynthetic process" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046505 ! sulfolipid metabolic process + +[Term] +id: GO:0046507 +name: UDPsulfoquinovose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose." [EC:3.13.1.1, RHEA:13197] +synonym: "sulfite:UDP-glucose sulfotransferase activity" EXACT [] +synonym: "UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity" RELATED [EC:3.13.1.1] +synonym: "UDP-sulfoquinovose synthase activity" RELATED [EC:3.13.1.1] +synonym: "UDPsulphoquinovose synthase activity" EXACT [] +xref: EC:3.13.1.1 +xref: KEGG_REACTION:R05775 +xref: MetaCyc:RXN-1223 +xref: RHEA:13197 +is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds + +[Term] +id: GO:0046508 +name: hydrolase activity, acting on carbon-sulfur bonds +namespace: molecular_function +def: "Catalysis of the hydrolysis of any carbon-sulfur bond, C-S." [GOC:jl] +synonym: "hydrolase activity, acting on carbon-sulphur bonds" EXACT [] +xref: EC:3.13.-.- +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0046509 +name: 1,2-diacylglycerol 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP." [EC:2.4.1.46, RHEA:14945] +synonym: "1-beta-MGDG activity" RELATED [EC:2.4.1.46] +synonym: "1beta-MGDG" RELATED [EC:2.4.1.46] +synonym: "MGDG synthase activity" EXACT [] +synonym: "monogalactosyldiacylglycerol synthase activity" EXACT [] +synonym: "UDP galactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose-diacylglyceride galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.46] +synonym: "UDP-galactose:diacylglycerol galactosyltransferase activity" EXACT [] +synonym: "UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.46] +synonym: "uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity" EXACT [] +xref: EC:2.4.1.46 +xref: KEGG_REACTION:R02691 +xref: MetaCyc:2.4.1.46-RXN +xref: RHEA:14945 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0046510 +name: UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP." [MetaCyc:RXN-1224] +synonym: "sulfolipid synthase" BROAD [] +synonym: "UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity" EXACT [] +xref: MetaCyc:RXN-1224 +xref: RHEA:49468 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0046511 +name: sphinganine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +synonym: "dihydrosphingosine biosynthesis" EXACT [] +synonym: "dihydrosphingosine biosynthetic process" EXACT [] +synonym: "sphinganine anabolism" EXACT [] +synonym: "sphinganine biosynthesis" EXACT [] +synonym: "sphinganine formation" EXACT [] +synonym: "sphinganine synthesis" EXACT [] +is_a: GO:0006667 ! sphinganine metabolic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0046512 +name: sphingosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732] +synonym: "sphingosine anabolism" EXACT [] +synonym: "sphingosine biosynthesis" EXACT [] +synonym: "sphingosine formation" EXACT [] +synonym: "sphingosine synthesis" EXACT [] +is_a: GO:0006670 ! sphingosine metabolic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0046513 +name: ceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid." [GOC:ai] +synonym: "ceramide anabolism" EXACT [] +synonym: "ceramide biosynthesis" EXACT [] +synonym: "ceramide formation" EXACT [] +synonym: "ceramide synthesis" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0030148 ! sphingolipid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0046514 +name: ceramide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." [GOC:ai] +synonym: "ceramide breakdown" EXACT [] +synonym: "ceramide catabolism" EXACT [] +synonym: "ceramide degradation" EXACT [] +is_a: GO:0006672 ! ceramide metabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0046516 +name: hypusine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ai] +synonym: "hypusine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0046517 +name: octamethylcyclotetrasiloxane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, PMID:10224038] +synonym: "octamethylcyclotetrasiloxane breakdown" EXACT [] +synonym: "octamethylcyclotetrasiloxane catabolism" EXACT [] +synonym: "octamethylcyclotetrasiloxane degradation" EXACT [] +is_a: GO:0046455 ! organosilicon catabolic process +is_a: GO:0046518 ! octamethylcyclotetrasiloxane metabolic process +is_a: GO:0046700 ! heterocycle catabolic process + +[Term] +id: GO:0046518 +name: octamethylcyclotetrasiloxane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octamethylcyclotetrasiloxane, a cyclic silicone-oxygen ring compound with two methyl groups attached to each silicone atom." [GOC:ai, http://chemfinder.cambridgesoft.com/] +synonym: "octamethylcyclotetrasiloxane metabolism" EXACT [] +is_a: GO:0018945 ! organosilicon metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046519 +name: sphingoid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] +synonym: "sphingoid base metabolic process" EXACT [] +synonym: "sphingoid base metabolism" EXACT [] +synonym: "sphingoid metabolism" EXACT [] +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:0046520 +name: sphingoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] +synonym: "sphingoid anabolism" EXACT [] +synonym: "sphingoid biosynthesis" EXACT [] +synonym: "sphingoid formation" EXACT [] +synonym: "sphingoid synthesis" EXACT [] +is_a: GO:0030148 ! sphingolipid biosynthetic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0046521 +name: sphingoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds." [ISBN:0198506732] +synonym: "sphingoid breakdown" EXACT [] +synonym: "sphingoid catabolism" EXACT [] +synonym: "sphingoid degradation" EXACT [] +is_a: GO:0030149 ! sphingolipid catabolic process +is_a: GO:0046519 ! sphingoid metabolic process + +[Term] +id: GO:0046522 +name: S-methyl-5-thioribose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.100, RHEA:22312] +synonym: "5-methylthioribose kinase (phosphorylating)" RELATED [EC:2.7.1.100] +synonym: "5-methylthioribose kinase activity" EXACT [] +synonym: "ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity" RELATED [EC:2.7.1.100] +synonym: "ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity" RELATED [EC:2.7.1.100] +synonym: "methylthioribose kinase activity" RELATED [EC:2.7.1.100] +synonym: "MTR kinase activity" RELATED [EC:2.7.1.100] +xref: EC:2.7.1.100 +xref: KEGG_REACTION:R04143 +xref: MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN +xref: RHEA:22312 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0046523 +name: S-methyl-5-thioribose-1-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate." [EC:5.3.1.23, RHEA:19989] +synonym: "1-phospho-5'-S-methylthioribose isomerase activity" RELATED [EC:5.3.1.23] +synonym: "1-PMTR isomerase activity" RELATED [EC:5.3.1.23] +synonym: "5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.23] +synonym: "5-methylthioribose-1-phosphate isomerase activity" EXACT [] +synonym: "methylthioribose 1-phosphate isomerase activity" RELATED [EC:5.3.1.23] +synonym: "MTR-1-P isomerase activity" RELATED [EC:5.3.1.23] +synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23] +synonym: "S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.23] +synonym: "S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23] +synonym: "S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.23] +xref: EC:5.3.1.23 +xref: KEGG_REACTION:R04420 +xref: MetaCyc:5.3.1.23-RXN +xref: Reactome:R-HSA-1237096 "Methylthio-ribose-P = Methylthio-ribulose-P" +xref: Reactome:R-HSA-1299507 "Methylthio-ribulose-P = Methylthio-ribose-P" +xref: RHEA:19989 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0046524 +name: sucrose-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate." [EC:2.4.1.14] +synonym: "SPS" RELATED [EC:2.4.1.14] +synonym: "sucrose 6-phosphate synthase activity" RELATED [EC:2.4.1.14] +synonym: "sucrose phosphate synthetase activity" RELATED [EC:2.4.1.14] +synonym: "sucrose phosphate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "sucrosephosphate-UDP glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "UDP-glucose-fructose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "UDPglucose-fructose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.14] +synonym: "uridine diphosphoglucose-fructose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.14] +xref: EC:2.4.1.14 +xref: MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN +xref: RHEA:22172 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0046525 +name: xylosylprotein 4-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.133] +synonym: "galactosyltransferase I activity" RELATED [EC:2.4.1.133] +synonym: "UDP-D-galactose:D-xylose galactosyltransferase activity" RELATED [EC:2.4.1.133] +synonym: "UDP-D-galactose:xylose galactosyltransferase activity" RELATED [EC:2.4.1.133] +synonym: "UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.133] +synonym: "UDP-galactose:xylose galactosyltransferase activity" EXACT [] +synonym: "UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.133] +synonym: "uridine diphosphogalactose-xylose galactosyltransferase activity" RELATED [EC:2.4.1.133] +xref: EC:2.4.1.133 +xref: MetaCyc:2.4.1.133-RXN +xref: Reactome:R-HSA-1889981 "B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker" +xref: Reactome:R-HSA-3560804 "Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker" +xref: RHEA:15297 +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0046526 +name: D-xylulose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH." [EC:1.1.1.9, RHEA:20433] +synonym: "xylitol dehydrogenase activity" RELATED [EC:1.1.1.9] +xref: EC:1.1.1.9 +xref: KEGG_REACTION:R01896 +xref: MetaCyc:D-XYLULOSE-REDUCTASE-RXN +xref: Reactome:R-HSA-5662471 "SORD tetramer oxidizes xylitol to D-xylulose" +xref: RHEA:20433 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0046527 +name: glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0046528 +name: imaginal disc fusion +namespace: biological_process +def: "The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis." [PMID:11494317] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007560 ! imaginal disc morphogenesis + +[Term] +id: GO:0046529 +name: imaginal disc fusion, thorax closure +namespace: biological_process +def: "The joining of the parts of the wing imaginal discs, giving rise to the adult thorax." [http://sdb.bio.purdue.edu/fly/gene/fos4.htm] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0046528 ! imaginal disc fusion + +[Term] +id: GO:0046530 +name: photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0007467 +def: "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster." [GOC:ai, ISBN:0198506732] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0046532 +name: regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045673 +def: "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] +synonym: "regulation of photoreceptor differentiation" EXACT [] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046533 +name: negative regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045674 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] +synonym: "down regulation of photoreceptor cell differentiation" EXACT [] +synonym: "down regulation of photoreceptor differentiation" EXACT [] +synonym: "down-regulation of photoreceptor cell differentiation" EXACT [] +synonym: "down-regulation of photoreceptor differentiation" EXACT [] +synonym: "downregulation of photoreceptor cell differentiation" EXACT [] +synonym: "downregulation of photoreceptor differentiation" EXACT [] +synonym: "inhibition of photoreceptor cell differentiation" NARROW [] +synonym: "inhibition of photoreceptor differentiation" NARROW [] +synonym: "negative regulation of photoreceptor differentiation" EXACT [] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046534 +name: positive regulation of photoreceptor cell differentiation +namespace: biological_process +alt_id: GO:0045675 +def: "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster." [GOC:go_curators] +synonym: "activation of photoreceptor cell differentiation" NARROW [] +synonym: "activation of photoreceptor differentiation" NARROW [] +synonym: "positive regulation of photoreceptor differentiation" EXACT [] +synonym: "stimulation of photoreceptor cell differentiation" NARROW [] +synonym: "stimulation of photoreceptor differentiation" NARROW [] +synonym: "up regulation of photoreceptor cell differentiation" EXACT [] +synonym: "up regulation of photoreceptor differentiation" EXACT [] +synonym: "up-regulation of photoreceptor cell differentiation" EXACT [] +synonym: "up-regulation of photoreceptor differentiation" EXACT [] +synonym: "upregulation of photoreceptor cell differentiation" EXACT [] +synonym: "upregulation of photoreceptor differentiation" EXACT [] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046535 +name: detection of chemical stimulus involved in sensory perception of umami taste +namespace: biological_process +def: "The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates." [GOC:ai, GOC:dos, PMID:11894099] +synonym: "perception of umami taste, detection of chemical stimulus" EXACT [] +synonym: "perception of umami taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of umami taste" EXACT [] +synonym: "sensory detection of umami taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of umami taste" EXACT [] +synonym: "sensory transduction of umami taste" EXACT [] +synonym: "umami taste detection" EXACT [] +is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste +relationship: part_of GO:0050917 ! sensory perception of umami taste + +[Term] +id: GO:0046536 +name: dosage compensation complex +namespace: cellular_component +def: "A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes." [GOC:kmv, GOC:mah] +subset: goslim_pir +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000785 ! chromatin +relationship: part_of GO:0000803 ! sex chromosome + +[Term] +id: GO:0046537 +name: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] +synonym: "PGAM-i" RELATED [EC:5.4.2.1] +is_a: GO:0004619 ! phosphoglycerate mutase activity + +[Term] +id: GO:0046538 +name: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate." [EC:5.4.2.1] +synonym: "glycerate phosphomutase (diphosphoglycerate cofactor) activity" RELATED [EC:5.4.2.1] +synonym: "PGAM-d" RELATED [EC:5.4.2.1] +is_a: GO:0004619 ! phosphoglycerate mutase activity + +[Term] +id: GO:0046539 +name: histamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.8, RHEA:19301] +synonym: "histamine 1-methyltransferase activity" RELATED [EC:2.1.1.8] +synonym: "histamine methyltransferase activity" RELATED [EC:2.1.1.8] +synonym: "histamine-methylating enzyme" RELATED [EC:2.1.1.8] +synonym: "imidazolemethyltransferase activity" RELATED [EC:2.1.1.8] +synonym: "S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity" RELATED [EC:2.1.1.8] +synonym: "S-adenosylmethionine-histamine N-methyltransferase activity" RELATED [EC:2.1.1.8] +xref: EC:2.1.1.8 +xref: KEGG_REACTION:R02155 +xref: MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN +xref: Reactome:R-HSA-175993 "HNMT transfers CH3 group from AdoMet to Hist" +xref: RHEA:19301 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046540 +name: U4/U6 x U5 tri-snRNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:11867543] +synonym: "U4/U6.U5 snRNP complex" EXACT [] +is_a: GO:0097526 ! spliceosomal tri-snRNP complex + +[Term] +id: GO:0046541 +name: saliva secretion +namespace: biological_process +def: "The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin." [GOC:curators, UBERON:0001836] +synonym: "salivation" EXACT [] +xref: Wikipedia:Salivation +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0022600 ! digestive system process +is_a: GO:0032941 ! secretion by tissue + +[Term] +id: GO:0046542 +name: obsolete alpha-factor export +namespace: biological_process +def: "OBSOLETE. The directed movement of alpha-factor, one of the two yeast mating factors, out of a cell." [GOC:ai] +comment: This term was made obsolete because it is a gene product based term and it does not involve a unique process. +synonym: "alpha-factor export" EXACT [] +is_obsolete: true +consider: GO:0015833 + +[Term] +id: GO:0046543 +name: development of secondary female sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045136 ! development of secondary sexual characteristics + +[Term] +id: GO:0046544 +name: development of secondary male sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045136 ! development of secondary sexual characteristics +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0046545 +name: development of primary female sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045137 ! development of primary sexual characteristics +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0046546 +name: development of primary male sexual characteristics +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion." [GOC:ai] +is_a: GO:0045137 ! development of primary sexual characteristics +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0046547 +name: trans-aconitate 3-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.145, RHEA:22200] +synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity" RELATED [EC:2.1.1.145] +xref: EC:2.1.1.145 +xref: KEGG_REACTION:R05764 +xref: MetaCyc:2.1.1.145-RXN +xref: RHEA:22200 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0046548 +name: retinal rod cell development +namespace: biological_process +def: "Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light." [ISBN:0198506732] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0060221 ! retinal rod cell differentiation + +[Term] +id: GO:0046549 +name: retinal cone cell development +namespace: biological_process +def: "Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision." [ISBN:0198506732] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0042670 ! retinal cone cell differentiation + +[Term] +id: GO:0046550 +name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine +namespace: biological_process +def: "The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7." [RESID:AA0328] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine" EXACT [] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine" EXACT [] +synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine" EXACT [] +xref: RESID:AA0328 +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process + +[Term] +id: GO:0046551 +name: retinal cone cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:mtg_sensu, PMID:3076112, PMID:3937883] +is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment +relationship: part_of GO:0042670 ! retinal cone cell differentiation + +[Term] +id: GO:0046552 +name: photoreceptor cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0046530 ! photoreceptor cell differentiation + +[Term] +id: GO:0046553 +name: D-malate dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate." [EC:1.1.1.83, RHEA:18365] +synonym: "(R)-malate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.83] +synonym: "bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)" RELATED [EC:1.1.1.83] +synonym: "D-malate dehydrogenase activity" RELATED [EC:1.1.1.83] +synonym: "D-malic enzyme" RELATED [EC:1.1.1.83] +xref: EC:1.1.1.83 +xref: KEGG_REACTION:R00215 +xref: MetaCyc:1.1.1.83-RXN +xref: RHEA:18365 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046554 +name: malate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+." [EC:1.1.1.82] +synonym: "(S)-malate:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.82, KEGG_REACTION:R00343] +synonym: "malate NADP dehydrogenase activity" RELATED [EC:1.1.1.82] +synonym: "malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.82] +synonym: "NADP malate dehydrogenase activity" RELATED [EC:1.1.1.82] +synonym: "NADP-linked malate dehydrogenase activity" RELATED [EC:1.1.1.82] +synonym: "NADP-malate dehydrogenase activity" RELATED [EC:1.1.1.82] +xref: EC:1.1.1.82 +xref: KEGG_REACTION:R00343 +xref: MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:10824 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046555 +name: acetylxylan esterase activity +namespace: molecular_function +def: "Catalysis of the deacetylation of xylans and xylo-oligosaccharides." [EC:3.1.1.72] +xref: EC:3.1.1.72 +xref: MetaCyc:3.1.1.72-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0046556 +name: alpha-L-arabinofuranosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." [EC:3.2.1.55, GOC:mf] +synonym: "alpha-arabinofuranosidase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-arabinosidase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-L-arabinanase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-L-arabinofuranoside arabinofuranohydrolase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-L-arabinofuranoside hydrolase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-L-arabinosidase activity" RELATED [EC:3.2.1.55] +synonym: "alpha-N-arabinofuranosidase activity" RELATED [] +synonym: "arabinofuranosidase activity" RELATED [EC:3.2.1.55] +synonym: "arabinosidase activity" RELATED [EC:3.2.1.55] +synonym: "L-arabinosidase activity" RELATED [EC:3.2.1.55] +synonym: "polysaccharide alpha-L-arabinofuranosidase activity" EXACT [] +xref: EC:3.2.1.55 +xref: MetaCyc:3.2.1.55-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046557 +name: glucan endo-1,6-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans." [EC:3.2.1.75] +synonym: "1,6-beta-D-glucan glucanohydrolase activity" RELATED [EC:3.2.1.75] +synonym: "beta-1,6-glucan 6-glucanohydrolase activity" RELATED [EC:3.2.1.75] +synonym: "beta-1,6-glucan hydrolase activity" RELATED [EC:3.2.1.75] +synonym: "beta-1,6-glucanase activity" RELATED [EC:3.2.1.75] +synonym: "beta-1,6-glucanase-pustulanase activity" RELATED [EC:3.2.1.75] +synonym: "beta-1->6-glucan hydrolase activity" RELATED [EC:3.2.1.75] +synonym: "endo-(1,6)-beta-D-glucanase activity" EXACT [] +synonym: "endo-(1->6)-beta-D-glucanase activity" RELATED [EC:3.2.1.75] +synonym: "endo-1,6-beta-D-glucanase activity" RELATED [EC:3.2.1.75] +synonym: "endo-1,6-beta-glucanase activity" RELATED [EC:3.2.1.75] +synonym: "endo-beta-1,6-glucanase activity" RELATED [EC:3.2.1.75] +xref: EC:3.2.1.75 +xref: MetaCyc:3.2.1.75-RXN +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0046558 +name: arabinan endo-1,5-alpha-L-arabinosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans." [EC:3.2.1.99] +synonym: "1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity" RELATED [EC:3.2.1.99] +synonym: "endo-1,5-alpha-L-arabinanase activity" RELATED [EC:3.2.1.99] +synonym: "endo-alpha-1,5-arabanase activity" RELATED [EC:3.2.1.99] +synonym: "endo-arabanase activity" RELATED [EC:3.2.1.99] +xref: EC:3.2.1.99 +xref: MetaCyc:3.2.1.99-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046559 +name: alpha-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.139] +synonym: "alpha-D-glucosiduronate glucuronohydrolase activity" RELATED [EC:3.2.1.139] +synonym: "alpha-glucosiduronase activity" RELATED [EC:3.2.1.139] +xref: EC:3.2.1.139 +xref: MetaCyc:3.2.1.139-RXN +xref: RHEA:20005 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046560 +name: obsolete scytalidopepsin B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, cleaving Phe24-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of insulin." [EC:3.4.23.32] +comment: This term was made obsolete because it represents a gene product. +synonym: "Ganoderma lucidum aspartic proteinase activity" RELATED [EC:3.4.23.32] +synonym: "Ganoderma lucidum carboxyl proteinase activity" RELATED [EC:3.4.23.32] +synonym: "Scytalidium aspartic proteinase B activity" RELATED [EC:3.4.23.32] +synonym: "Scytalidium lignicolum aspartic proteinase B" RELATED [EC:3.4.23.32] +synonym: "scytalidopepsin B activity" EXACT [] +synonym: "SLB" RELATED [EC:3.4.23.32] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0046561 +name: obsolete penicillopepsin activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving Gly20-Glu in the B chain of insulin. Clots milk, and activates trypsinogen." [EC:3.4.23.20] +comment: This term was made obsolete because it represents a gene product. +synonym: "acid protease A" EXACT [] +synonym: "Penicillium aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium caseicolum aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium citrinum acid proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium citrinum aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium cyclopium acid proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium duponti aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium expansum acid proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium expansum aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium janthinellum acid proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium janthinellum aspartic protease activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium janthinellum aspartic proteinase activity" RELATED [EC:3.4.23.20] +synonym: "Penicillium roqueforti acid proteinase activity" RELATED [EC:3.4.23.20] +synonym: "penicillopepsin activity" EXACT [] +synonym: "peptidase A activity" BROAD [EC:3.4.23.20] +is_obsolete: true +replaced_by: GO:0004190 + +[Term] +id: GO:0046562 +name: glucose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2." [EC:1.1.3.4, GOC:mah] +synonym: "beta-D-glucose oxidase activity" EXACT [] +synonym: "beta-D-glucose:oxygen 1-oxido-reductase activity" RELATED [EC:1.1.3.4] +synonym: "beta-D-glucose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.4] +synonym: "beta-D-glucose:quinone oxidoreductase activity" RELATED [EC:1.1.3.4] +synonym: "corylophyline" RELATED [EC:1.1.3.4] +synonym: "D-glucose oxidase activity" RELATED [EC:1.1.3.4] +synonym: "D-glucose-1-oxidase activity" RELATED [EC:1.1.3.4] +synonym: "deoxin-1" RELATED [EC:1.1.3.4] +synonym: "glucose aerodehydrogenase activity" RELATED [EC:1.1.3.4] +synonym: "glucose oxyhydrase activity" RELATED [EC:1.1.3.4] +synonym: "GOD activity" RELATED [EC:1.1.3.4] +synonym: "microcid" RELATED [EC:1.1.3.4] +synonym: "penatin" RELATED [EC:1.1.3.4] +xref: EC:1.1.3.4 +xref: KEGG_REACTION:R01522 +xref: MetaCyc:GLUCOSE-OXIDASE-RXN +xref: RHEA:11428 +is_a: GO:0047979 ! hexose oxidase activity + +[Term] +id: GO:0046563 +name: methanol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde." [MetaCyc:METHANOL-OXIDASE-RXN] +comment: Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). +xref: EC:1.1.3.- +xref: MetaCyc:METHANOL-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0046564 +name: oxalate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + oxalate = CO(2) + formate." [EC:4.1.1.2, RHEA:16509] +synonym: "oxalate carboxy-lyase (formate-forming)" RELATED [EC:4.1.1.2] +synonym: "oxalate carboxy-lyase activity" RELATED [EC:4.1.1.2] +xref: EC:4.1.1.2 +xref: KEGG_REACTION:R00522 +xref: MetaCyc:OXALATE-DECARBOXYLASE-RXN +xref: RHEA:16509 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0046565 +name: 3-dehydroshikimate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate." [EC:4.2.1.118, MetaCyc:DHSHIKIMATE-DEHYDRO-RXN] +xref: EC:4.2.1.118 +xref: MetaCyc:DHSHIKIMATE-DEHYDRO-RXN +xref: RHEA:24848 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046566 +name: DOPA dioxygenase activity +namespace: molecular_function +def: "Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid." [PMID:11711071] +synonym: "dihydroxyphenylalanine dioxygenase activity" EXACT [] +xref: MetaCyc:RXN-8460 +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0046567 +name: aphidicolan-16 beta-ol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate." [EC:4.2.3.42, PMID:12149019] +synonym: "9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming)" RELATED [EC:4.2.3.42] +xref: EC:4.2.3.42 +xref: KEGG_REACTION:R06313 +xref: MetaCyc:RXN-10631 +xref: RHEA:26213 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0046568 +name: 3-methylbutanol:NAD(P) oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265] +synonym: "3-methylbutanal reductase [NAD(P)] activity" RELATED [EC:1.1.1.265] +synonym: "3-methylbutyraldehyde reductase activity" EXACT [] +synonym: "isoamyl alcohol oxidase activity" EXACT [] +xref: EC:1.1.1.265 +xref: MetaCyc:1.1.1.265-RXN +is_a: GO:0018455 ! alcohol dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0046569 +name: glyoxal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2." [PMID:11733005] +synonym: "GLOX" EXACT [] +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0046570 +name: methylthioribulose 1-phosphate dehydratase activity +namespace: molecular_function +alt_id: GO:0043809 +def: "Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O." [EC:4.2.1.109, RHEA:15549] +synonym: "1-PMT-ribulose dehydratase activity" RELATED [EC:4.2.1.109] +synonym: "5-methylthioribulose-1-phosphate 4-dehydratase activity" EXACT [MetaCyc:R145-RXN] +synonym: "methylthioribulose-1-phosphate dehydratase activity" EXACT [] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" RELATED [EC:4.2.1.109] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity" EXACT [] +synonym: "S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]" EXACT [] +xref: EC:4.2.1.109 +xref: KEGG_REACTION:R07392 +xref: MetaCyc:R145-RXN +xref: Reactome:R-HSA-1237140 "Dehydration of methylthio-ribulose-P" +xref: RHEA:15549 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0046571 +name: aspartate-2-keto-4-methylthiobutyrate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate." [MetaCyc:R15-RXN] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0046572 +name: versicolorin B synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: versiconal = versicolorin B + H2O." [MetaCyc:RXN-9494, PMID:8784203] +xref: EC:4.2.1.143 +xref: MetaCyc:RXN-9494 +xref: RHEA:33859 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0046573 +name: lactonohydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group." [PMID:11640988] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0046574 +name: glycuronidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." [PMID:10441389, PMID:12044176] +synonym: "glucuronyl hydrolase activity" EXACT [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0046575 +name: rhamnogalacturonan acetylesterase activity +namespace: molecular_function +def: "Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan." [PMID:10801485] +is_a: GO:0008126 ! acetylesterase activity + +[Term] +id: GO:0046576 +name: rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue." [PMID:8587995, PMID:8720076] +synonym: "rhamnogalacturonase B activity" EXACT [PMID:8587995] +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0046577 +name: long-chain-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O." [EC:1.1.3.20] +synonym: "fatty alcohol oxidase activity" EXACT [] +synonym: "fatty alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.20] +synonym: "long-chain fatty acid oxidase activity" RELATED [EC:1.1.3.20] +synonym: "long-chain fatty alcohol oxidase activity" EXACT [] +synonym: "long-chain-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.20] +xref: EC:1.1.3.20 +xref: MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN +xref: RHEA:22756 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0046578 +name: regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +relationship: regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046579 +name: positive regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +synonym: "activation of Ras protein signal transduction" NARROW [] +synonym: "stimulation of Ras protein signal transduction" NARROW [] +synonym: "up regulation of Ras protein signal transduction" EXACT [] +synonym: "up-regulation of Ras protein signal transduction" EXACT [] +synonym: "upregulation of Ras protein signal transduction" EXACT [] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +is_a: GO:0051057 ! positive regulation of small GTPase mediated signal transduction +relationship: positively_regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046580 +name: negative regulation of Ras protein signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction." [GOC:bf] +synonym: "down regulation of Ras protein signal transduction" EXACT [] +synonym: "down-regulation of Ras protein signal transduction" EXACT [] +synonym: "downregulation of Ras protein signal transduction" EXACT [] +synonym: "inhibition of Ras protein signal transduction" NARROW [] +is_a: GO:0046578 ! regulation of Ras protein signal transduction +is_a: GO:0051058 ! negative regulation of small GTPase mediated signal transduction +relationship: negatively_regulates GO:0007265 ! Ras protein signal transduction + +[Term] +id: GO:0046581 +name: intercellular canaliculus +namespace: cellular_component +def: "An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates." [ISBN:0721662544] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0046583 +name: cation efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "cation efflux permease activity" EXACT [] +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0046584 +name: enniatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732] +synonym: "enniatin metabolism" EXACT [] +is_a: GO:0016999 ! antibiotic metabolic process +is_a: GO:0050761 ! depsipeptide metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:0046585 +name: enniatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores." [ISBN:0198506732] +synonym: "enniatin anabolism" EXACT [] +synonym: "enniatin biosynthesis" EXACT [] +synonym: "enniatin formation" EXACT [] +synonym: "enniatin synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0046584 ! enniatin metabolic process +is_a: GO:0050763 ! depsipeptide biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0046586 +name: regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:ai] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules + +[Term] +id: GO:0046587 +name: positive regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] +synonym: "activation of calcium-dependent cell-cell adhesion" NARROW [] +synonym: "stimulation of calcium-dependent cell-cell adhesion" NARROW [] +synonym: "up regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "up-regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "upregulation of calcium-dependent cell-cell adhesion" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion +relationship: positively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules + +[Term] +id: GO:0046588 +name: negative regulation of calcium-dependent cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-dependent cell-cell adhesion." [GOC:ai] +synonym: "down regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "down-regulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "downregulation of calcium-dependent cell-cell adhesion" EXACT [] +synonym: "inhibition of calcium-dependent cell-cell adhesion" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0046586 ! regulation of calcium-dependent cell-cell adhesion +relationship: negatively_regulates GO:0016339 ! calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules + +[Term] +id: GO:0046589 +name: ribonuclease T1 activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates." [GOC:curators] +synonym: "Aspergillus oryzae ribonuclease activity" NARROW [EC:4.6.1.24] +synonym: "binase activity" RELATED [] +synonym: "guanyl-specific RNase activity" RELATED [] +synonym: "guanyloribonuclease activity" RELATED [EC:4.6.1.24] +synonym: "ribonuclease C2" RELATED [] +synonym: "ribonuclease Ch" RELATED [EC:3.1.27.3] +synonym: "ribonuclease F1" EXACT [] +synonym: "ribonuclease guaninenucleotido-2'-transferase (cyclizing)" RELATED [EC:4.6.1.24] +synonym: "ribonuclease N1" RELATED [EC:4.6.1.24] +synonym: "ribonuclease N3" RELATED [] +synonym: "ribonuclease PP1" RELATED [] +synonym: "ribonuclease SA" RELATED [] +synonym: "ribonuclease U1" RELATED [] +synonym: "RNase F1" RELATED [] +synonym: "RNase G" RELATED [] +synonym: "RNase N1 activity" RELATED [EC:4.6.1.24] +synonym: "RNase N2 activity" RELATED [EC:4.6.1.24] +synonym: "RNase Sa" RELATED [] +synonym: "RNase T1" RELATED [EC:4.6.1.24] +synonym: "RNase T1 activity" EXACT [] +xref: EC:4.6.1.24 +xref: MetaCyc:3.1.27.3-RXN +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0046590 +name: obsolete embryonic leg morphogenesis +namespace: biological_process +def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg are generated and organized. A leg is a limb on which an animal walks and stands." [GOC:bf] +comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. +synonym: "embryonic leg morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0030326 +consider: GO:0035116 + +[Term] +id: GO:0046591 +name: obsolete embryonic leg joint morphogenesis +namespace: biological_process +def: "OBSOLETE. The process, occurring in the embryo, by which the anatomical structures of the leg joint are generated and organized. A leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner." [GOC:bf, ISBN:0582227089, PMID:12051824] +comment: This term was made obsolete because leg is a mechano-functional grouping, and having both 'leg morphogenesis' and 'hindlimb morphogenesis' terms causes errors in querying. +synonym: "embryonic leg joint morphogenesis" EXACT [] +is_obsolete: true +consider: GO:0036023 + +[Term] +id: GO:0046592 +name: polyamine oxidase activity +namespace: molecular_function +def: "Catalysis of the oxidative degradation or interconversion of polyamines." [PMID:1567380] +synonym: "1-N-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [] +synonym: "N1-acetylspermidine:oxygen oxidoreductase (deaminating)" NARROW [] +xref: MetaCyc:POLYAMINE-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0046593 +name: mandelonitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." [EC:4.1.2.10] +synonym: "(R)-oxynitrilase activity" RELATED [EC:4.1.2.10] +synonym: "D-alpha-hydroxynitrile lyase activity" RELATED [EC:4.1.2.10] +synonym: "D-oxynitrilase activity" RELATED [EC:4.1.2.10] +synonym: "hydroxynitrile lyase activity" BROAD [] +synonym: "mandelonitrile benzaldehyde-lyase (cyanide-forming)" RELATED [EC:4.1.2.10] +synonym: "mandelonitrile benzaldehyde-lyase activity" RELATED [EC:4.1.2.10] +xref: EC:4.1.2.10 +xref: MetaCyc:MANDELONITRILE-LYASE-RXN +xref: RHEA:18313 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0046594 +name: maintenance of pole plasm mRNA location +namespace: biological_process +alt_id: GO:0048122 +def: "The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:tb] +synonym: "maintenance of oocyte pole plasm mRNA localization" EXACT [] +synonym: "maintenance of pole plasm mRNA localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051237 ! maintenance of RNA location +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0046595 +name: establishment of pole plasm mRNA localization +namespace: biological_process +alt_id: GO:0048121 +def: "Any process that results in the directed movement of mRNA to the oocyte pole plasm." [GOC:bf] +synonym: "establishment of oocyte pole plasm mRNA localization" EXACT [] +synonym: "establishment of pole plasm mRNA localisation" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0051236 ! establishment of RNA localization +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0019094 ! pole plasm mRNA localization + +[Term] +id: GO:0046596 +name: regulation of viral entry into host cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the viral entry into the host cell." [GOC:jl] +synonym: "regulation of viral penetration into host cell" EXACT [] +synonym: "viral escort protein" RELATED [GOC:bm] +is_a: GO:0052372 ! modulation by symbiont of entry into host +is_a: GO:1903900 ! regulation of viral life cycle +relationship: regulates GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0046597 +name: negative regulation of viral entry into host cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell." [GOC:jl] +synonym: "negative regulation of viral penetration into host cell" EXACT [] +is_a: GO:0046596 ! regulation of viral entry into host cell +is_a: GO:1903901 ! negative regulation of viral life cycle +relationship: negatively_regulates GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0046598 +name: positive regulation of viral entry into host cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell." [GOC:jl] +synonym: "positive regulation of viral penetration into host cell" EXACT [] +is_a: GO:0046596 ! regulation of viral entry into host cell +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +is_a: GO:1903902 ! positive regulation of viral life cycle +relationship: positively_regulates GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0046599 +name: regulation of centriole replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole." [GOC:ai] +is_a: GO:0010824 ! regulation of centrosome duplication +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046600 +name: negative regulation of centriole replication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication." [GOC:ai] +synonym: "down regulation of centriole replication" EXACT [] +synonym: "down-regulation of centriole replication" EXACT [] +synonym: "downregulation of centriole replication" EXACT [] +synonym: "inhibition of centriole replication" NARROW [] +is_a: GO:0010826 ! negative regulation of centrosome duplication +is_a: GO:0046599 ! regulation of centriole replication +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046601 +name: positive regulation of centriole replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centriole replication." [GOC:ai] +synonym: "activation of centriole replication" NARROW [] +synonym: "stimulation of centriole replication" NARROW [] +synonym: "up regulation of centriole replication" EXACT [] +synonym: "up-regulation of centriole replication" EXACT [] +synonym: "upregulation of centriole replication" EXACT [] +is_a: GO:0046599 ! regulation of centriole replication +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0007099 ! centriole replication + +[Term] +id: GO:0046602 +name: regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis." [GOC:ai] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046603 +name: negative regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of centrosome separation." [GOC:ai] +synonym: "down regulation of mitotic centrosome separation" EXACT [] +synonym: "down-regulation of mitotic centrosome separation" EXACT [] +synonym: "downregulation of mitotic centrosome separation" EXACT [] +synonym: "inhibition of mitotic centrosome separation" NARROW [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0046602 ! regulation of mitotic centrosome separation +relationship: negatively_regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046604 +name: positive regulation of mitotic centrosome separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centrosome separation." [GOC:ai] +synonym: "activation of mitotic centrosome separation" NARROW [] +synonym: "stimulation of mitotic centrosome separation" NARROW [] +synonym: "up regulation of mitotic centrosome separation" EXACT [] +synonym: "up-regulation of mitotic centrosome separation" EXACT [] +synonym: "upregulation of mitotic centrosome separation" EXACT [] +is_a: GO:0046602 ! regulation of mitotic centrosome separation +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0007100 ! mitotic centrosome separation + +[Term] +id: GO:0046605 +name: regulation of centrosome cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation." [GOC:ai] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0032886 ! regulation of microtubule-based process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046606 +name: negative regulation of centrosome cycle +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle." [GOC:ai] +synonym: "down regulation of centrosome cycle" EXACT [] +synonym: "down-regulation of centrosome cycle" EXACT [] +synonym: "downregulation of centrosome cycle" EXACT [] +synonym: "inhibition of centrosome cycle" NARROW [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0046605 ! regulation of centrosome cycle +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046607 +name: positive regulation of centrosome cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the centrosome cycle." [GOC:ai] +synonym: "activation of centrosome cycle" NARROW [] +synonym: "stimulation of centrosome cycle" NARROW [] +synonym: "up regulation of centrosome cycle" EXACT [] +synonym: "up-regulation of centrosome cycle" EXACT [] +synonym: "upregulation of centrosome cycle" EXACT [] +is_a: GO:0046605 ! regulation of centrosome cycle +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0007098 ! centrosome cycle + +[Term] +id: GO:0046608 +name: carotenoid isomerase activity +namespace: molecular_function +def: "Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids." [PMID:11884677] +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0046609 +name: obsolete voltage-gated sulfate antiporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + solute(in) = solute(in) + sulfate(out), by a channel in a cell membrane whose opening is governed by the membrane potential." [GOC:mah] +comment: This term was obsoleted because there is no evidence that this function exists. +synonym: "prestin" NARROW [] +synonym: "voltage gated sulfate antiporter activity" EXACT [] +synonym: "voltage-dependent sulfate antiporter activity" EXACT [] +synonym: "voltage-sensitive sulfate antiporter activity" EXACT [] +synonym: "voltage-sensitive sulphate antiporter activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046610 +name: lysosomal proton-transporting V-type ATPase, V0 domain +namespace: cellular_component +def: "The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] +synonym: "lysosomal hydrogen ion-transporting ATPase V0 domain" EXACT [] +is_a: GO:0000220 ! vacuolar proton-transporting V-type ATPase, V0 domain +relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex + +[Term] +id: GO:0046611 +name: lysosomal proton-transporting V-type ATPase complex +namespace: cellular_component +def: "A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] +synonym: "lysosomal hydrogen-translocating V-type ATPase complex" EXACT [] +synonym: "lysosomal membrane hydrogen-transporting ATPase" BROAD [] +is_a: GO:0016471 ! vacuolar proton-transporting V-type ATPase complex +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0046612 +name: lysosomal proton-transporting V-type ATPase, V1 domain +namespace: cellular_component +def: "The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane." [GOC:mah] +synonym: "lysosomal hydrogen ion-transporting ATPase V1 domain" EXACT [] +is_a: GO:0000221 ! vacuolar proton-transporting V-type ATPase, V1 domain +relationship: part_of GO:0046611 ! lysosomal proton-transporting V-type ATPase complex + +[Term] +id: GO:0046615 +name: obsolete re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. The resumption of the Saccharomyces mitotic cell division cycle by pheromone-arrested cells that have not mated." [GOC:krc, PMID:9927449] +comment: This term was made obsolete because there is no evidence that this process is unique to Saccharomyces. +synonym: "re-entry into mitotic cell cycle after pheromone arrest (sensu Saccharomyces)" EXACT [] +is_obsolete: true +replaced_by: GO:0000321 + +[Term] +id: GO:0046617 +name: obsolete nucleolar size increase (sensu Saccharomyces) +namespace: biological_process +def: "OBSOLETE. The process of nucleolar expansion, as seen in Saccharomyces." [GOC:ai] +comment: This term was made obsolete because it does not describe a biological process. +synonym: "nucleolar size increase (sensu Saccharomyces)" EXACT [] +is_obsolete: true +consider: GO:0007571 +consider: GO:0007576 + +[Term] +id: GO:0046618 +name: xenobiotic export +namespace: biological_process +def: "The directed movement of a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:go_curators, GOC:krc] +synonym: "drug export" RELATED [] +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0046619 +name: lens placode formation involved in camera-type eye formation +namespace: biological_process +def: "Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] +synonym: "optic placode formation in camera-type eye" EXACT [] +synonym: "optic placode formation involved in camera-style eye" EXACT [] +synonym: "optic placode formation involved in camera-type eye formation" RELATED [] +is_a: GO:0001743 ! lens placode formation +relationship: part_of GO:0060900 ! embryonic camera-type eye formation + +[Term] +id: GO:0046620 +name: regulation of organ growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046621 +name: negative regulation of organ growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +is_a: GO:0046620 ! regulation of organ growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046622 +name: positive regulation of organ growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism." [GOC:bf, GOC:tb] +is_a: GO:0046620 ! regulation of organ growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0035265 ! organ growth + +[Term] +id: GO:0046623 +name: sphingolipid floppase activity +namespace: molecular_function +def: "Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ai, PMID:12034738] +synonym: "sphingolipid flippase activity" EXACT [] +synonym: "sphingolipid floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "sphingolipid-translocating ATPase activity" RELATED [] +is_a: GO:0046624 ! sphingolipid transporter activity +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0046624 +name: sphingolipid transporter activity +namespace: molecular_function +def: "Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ai, ISBN:0198506732] +xref: Reactome:R-HSA-9695890 "SPNS2 transports S1P from cytosol to extracellular region" +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0046625 +name: sphingolipid binding +namespace: molecular_function +def: "Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [ISBN:0198506732] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0046626 +name: regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046627 +name: negative regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "down regulation of insulin receptor signaling pathway" EXACT [] +synonym: "down-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "downregulation of insulin receptor signaling pathway" EXACT [] +synonym: "inhibition of insulin receptor signaling pathway" NARROW [] +synonym: "negative regulation of insulin receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +is_a: GO:1900077 ! negative regulation of cellular response to insulin stimulus +relationship: negatively_regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046628 +name: positive regulation of insulin receptor signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of insulin receptor signaling." [GOC:bf] +synonym: "activation of insulin receptor signaling pathway" NARROW [] +synonym: "positive regulation of insulin receptor signalling pathway" EXACT [] +synonym: "stimulation of insulin receptor signaling pathway" NARROW [] +synonym: "up regulation of insulin receptor signaling pathway" EXACT [] +synonym: "up-regulation of insulin receptor signaling pathway" EXACT [] +synonym: "upregulation of insulin receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +is_a: GO:1900078 ! positive regulation of cellular response to insulin stimulus +relationship: positively_regulates GO:0008286 ! insulin receptor signaling pathway + +[Term] +id: GO:0046629 +name: gamma-delta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] +synonym: "gamma-delta T lymphocyte activation" EXACT [] +synonym: "gamma-delta T-cell activation" EXACT [] +synonym: "gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0046630 +name: gamma-delta T cell proliferation +namespace: biological_process +def: "The expansion of a gamma-delta T cell population by cell division." [GOC:ai] +synonym: "gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "gamma-delta T-cell proliferation" EXACT [] +synonym: "gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +is_a: GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046631 +name: alpha-beta T cell activation +namespace: biological_process +def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:add] +synonym: "alpha-beta T lymphocyte activation" EXACT [] +synonym: "alpha-beta T-cell activation" EXACT [] +synonym: "alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0042110 ! T cell activation + +[Term] +id: GO:0046632 +name: alpha-beta T cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex." [CL:0000789, GOC:ai] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "alpha-beta T cell development" RELATED [GOC:add] +synonym: "alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "alpha-beta T-cell differentiation" EXACT [] +synonym: "alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0030217 ! T cell differentiation +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046633 +name: alpha-beta T cell proliferation +namespace: biological_process +def: "The expansion of an alpha-beta T cell population by cell division." [GOC:ai] +synonym: "alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "alpha-beta T-cell proliferation" EXACT [] +synonym: "alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042098 ! T cell proliferation +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046634 +name: regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "regulation of alpha-beta T-cell activation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046635 +name: positive regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "activation of alpha-beta T cell activation" NARROW [] +synonym: "positive regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell activation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte activation" EXACT [] +synonym: "stimulation of alpha-beta T cell activation" NARROW [] +synonym: "up regulation of alpha-beta T cell activation" EXACT [] +synonym: "up-regulation of alpha-beta T cell activation" EXACT [] +synonym: "upregulation of alpha-beta T cell activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046636 +name: negative regulation of alpha-beta T cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation." [GOC:ai] +synonym: "down regulation of alpha-beta T cell activation" EXACT [] +synonym: "down-regulation of alpha-beta T cell activation" EXACT [] +synonym: "downregulation of alpha-beta T cell activation" EXACT [] +synonym: "inhibition of alpha-beta T cell activation" NARROW [] +synonym: "negative regulation of alpha-beta T lymphocyte activation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell activation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0046637 +name: regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of alpha-beta T cell development" RELATED [GOC:add] +synonym: "regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046638 +name: positive regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of alpha-beta T cell differentiation" NARROW [] +synonym: "positive regulation of alpha-beta T cell development" RELATED [GOC:add] +synonym: "positive regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +synonym: "stimulation of alpha-beta T cell differentiation" NARROW [] +synonym: "up regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "up-regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "upregulation of alpha-beta T cell differentiation" EXACT [] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: positively_regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046639 +name: negative regulation of alpha-beta T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell differentiation." [GOC:ai] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "down-regulation of alpha-beta T cell differentiation" EXACT [] +synonym: "downregulation of alpha-beta T cell differentiation" EXACT [] +synonym: "inhibition of alpha-beta T cell differentiation" NARROW [] +synonym: "negative regulation of alpha-beta T cell development" RELATED [GOC:add] +synonym: "negative regulation of alpha-beta T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell differentiation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte differentiation" EXACT [] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: negatively_regulates GO:0046632 ! alpha-beta T cell differentiation + +[Term] +id: GO:0046640 +name: regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046641 +name: positive regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "activation of alpha-beta T cell proliferation" NARROW [] +synonym: "positive regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "positive regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of alpha-beta T cell proliferation" NARROW [] +synonym: "up regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "up-regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "upregulation of alpha-beta T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +relationship: positively_regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046642 +name: negative regulation of alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation." [GOC:ai] +synonym: "down regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "down-regulation of alpha-beta T cell proliferation" EXACT [] +synonym: "downregulation of alpha-beta T cell proliferation" EXACT [] +synonym: "inhibition of alpha-beta T cell proliferation" NARROW [] +synonym: "negative regulation of alpha-beta T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of alpha-beta T-cell proliferation" EXACT [] +synonym: "negative regulation of alpha-beta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +relationship: negatively_regulates GO:0046633 ! alpha-beta T cell proliferation + +[Term] +id: GO:0046643 +name: regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "regulation of gamma-delta T-cell activation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046644 +name: negative regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "down regulation of gamma-delta T cell activation" EXACT [] +synonym: "down-regulation of gamma-delta T cell activation" EXACT [] +synonym: "downregulation of gamma-delta T cell activation" EXACT [] +synonym: "inhibition of gamma-delta T cell activation" NARROW [] +synonym: "negative regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell activation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte activation" EXACT [] +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +is_a: GO:0050868 ! negative regulation of T cell activation +relationship: negatively_regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046645 +name: positive regulation of gamma-delta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation." [GOC:ai] +synonym: "activation of gamma-delta T cell activation" NARROW [] +synonym: "positive regulation of gamma-delta T lymphocyte activation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell activation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte activation" EXACT [] +synonym: "stimulation of gamma-delta T cell activation" NARROW [] +synonym: "up regulation of gamma-delta T cell activation" EXACT [] +synonym: "up-regulation of gamma-delta T cell activation" EXACT [] +synonym: "upregulation of gamma-delta T cell activation" EXACT [] +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +is_a: GO:0050870 ! positive regulation of T cell activation +relationship: positively_regulates GO:0046629 ! gamma-delta T cell activation + +[Term] +id: GO:0046646 +name: regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042129 ! regulation of T cell proliferation +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +relationship: regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046647 +name: negative regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "down regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "down-regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "downregulation of gamma-delta T cell proliferation" EXACT [] +synonym: "inhibition of gamma-delta T cell proliferation" NARROW [] +synonym: "negative regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "negative regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +is_a: GO:0042130 ! negative regulation of T cell proliferation +is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation +is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation +relationship: negatively_regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046648 +name: positive regulation of gamma-delta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell proliferation." [GOC:ai] +synonym: "activation of gamma-delta T cell proliferation" NARROW [] +synonym: "positive regulation of gamma-delta T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of gamma-delta T-cell proliferation" EXACT [] +synonym: "positive regulation of gamma-delta T-lymphocyte proliferation" EXACT [] +synonym: "stimulation of gamma-delta T cell proliferation" NARROW [] +synonym: "up regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "up-regulation of gamma-delta T cell proliferation" EXACT [] +synonym: "upregulation of gamma-delta T cell proliferation" EXACT [] +is_a: GO:0042102 ! positive regulation of T cell proliferation +is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation +is_a: GO:0046646 ! regulation of gamma-delta T cell proliferation +relationship: positively_regulates GO:0046630 ! gamma-delta T cell proliferation + +[Term] +id: GO:0046649 +name: lymphocyte activation +namespace: biological_process +def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] +is_a: GO:0045321 ! leukocyte activation + +[Term] +id: GO:0046651 +name: lymphocyte proliferation +namespace: biological_process +def: "The expansion of a lymphocyte population by cell division." [GOC:ai] +is_a: GO:0032943 ! mononuclear cell proliferation +is_a: GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0046653 +name: tetrahydrofolate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732] +synonym: "tetrahydrofolate metabolism" EXACT [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process + +[Term] +id: GO:0046654 +name: tetrahydrofolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group." [ISBN:0198506732] +synonym: "tetrahydrofolate anabolism" EXACT [] +synonym: "tetrahydrofolate biosynthesis" EXACT [] +synonym: "tetrahydrofolate formation" EXACT [] +synonym: "tetrahydrofolate synthesis" EXACT [] +xref: MetaCyc:FOLSYN-PWY +is_a: GO:0009396 ! folic acid-containing compound biosynthetic process +is_a: GO:0046653 ! tetrahydrofolate metabolic process + +[Term] +id: GO:0046655 +name: folic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [ISBN:0198506732] +synonym: "folate metabolic process" EXACT [] +synonym: "folate metabolism" EXACT [] +synonym: "folic acid metabolism" EXACT [] +synonym: "vitamin B9 metabolic process" EXACT [] +synonym: "vitamin B9 metabolism" EXACT [] +synonym: "vitamin M metabolic process" EXACT [] +synonym: "vitamin M metabolism" EXACT [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process +is_a: GO:0006767 ! water-soluble vitamin metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:0046656 +name: folic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid." [GOC:ai] +synonym: "folate biosynthesis" EXACT [] +synonym: "folate biosynthetic process" EXACT [] +synonym: "folic acid anabolism" EXACT [] +synonym: "folic acid biosynthesis" EXACT [] +synonym: "folic acid formation" EXACT [] +synonym: "folic acid synthesis" EXACT [] +synonym: "vitamin B9 biosynthesis" EXACT [] +synonym: "vitamin B9 biosynthetic process" EXACT [] +synonym: "vitamin M biosynthesis" EXACT [] +synonym: "vitamin M biosynthetic process" EXACT [] +xref: MetaCyc:FOLSYN-PWY +xref: Wikipedia:Folic_acid +is_a: GO:0009396 ! folic acid-containing compound biosynthetic process +is_a: GO:0042364 ! water-soluble vitamin biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046655 ! folic acid metabolic process + +[Term] +id: GO:0046657 +name: folic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid." [GOC:ai] +synonym: "folate catabolic process" EXACT [] +synonym: "folate catabolism" EXACT [] +synonym: "folic acid breakdown" EXACT [] +synonym: "folic acid catabolism" EXACT [] +synonym: "folic acid degradation" EXACT [] +synonym: "vitamin B9 catabolic process" EXACT [] +synonym: "vitamin B9 catabolism" EXACT [] +synonym: "vitamin M catabolic process" EXACT [] +synonym: "vitamin M catabolism" EXACT [] +is_a: GO:0009397 ! folic acid-containing compound catabolic process +is_a: GO:0042365 ! water-soluble vitamin catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:0046655 ! folic acid metabolic process + +[Term] +id: GO:0046658 +name: anchored component of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] +synonym: "anchored to plasma membrane" NARROW [] +synonym: "plasma membrane, GPI-anchored" NARROW [] +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0031226 ! intrinsic component of plasma membrane + +[Term] +id: GO:0046659 +name: digestive hormone activity +namespace: molecular_function +def: "The action characteristic of a hormone that takes part in the digestion process." [GOC:ai] +synonym: "secretin" NARROW [] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0046660 +name: female sex differentiation +namespace: biological_process +def: "The establishment of the sex of a female organism by physical differentiation." [GOC:bf] +is_a: GO:0007548 ! sex differentiation +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0046661 +name: male sex differentiation +namespace: biological_process +def: "The establishment of the sex of a male organism by physical differentiation." [GOC:bf] +is_a: GO:0007548 ! sex differentiation +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0046662 +name: regulation of oviposition +namespace: biological_process +alt_id: GO:0048042 +def: "Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium." [GOC:dph, GOC:tb, PMID:11932766] +synonym: "regulation of post-mating oviposition" NARROW [] +is_a: GO:0050795 ! regulation of behavior +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0018991 ! oviposition + +[Term] +id: GO:0046663 +name: dorsal closure, leading edge cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure." [GOC:ai, PMID:12147138] +is_a: GO:0035026 ! leading edge cell differentiation +relationship: part_of GO:0007392 ! initiation of dorsal closure + +[Term] +id: GO:0046664 +name: dorsal closure, amnioserosa morphology change +namespace: biological_process +def: "The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo." [PMID:12147138] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0007391 ! dorsal closure + +[Term] +id: GO:0046665 +name: amnioserosa maintenance +namespace: biological_process +def: "Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis." [GOC:bf] +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0046666 +name: retinal cell programmed cell death +namespace: biological_process +def: "Programmed cell death that occurs in the developing retina." [GOC:bf] +synonym: "programmed cell death, retina cells" EXACT [] +synonym: "programmed cell death, retinal cells" EXACT [] +synonym: "retina cell programmed cell death" EXACT [] +synonym: "retina programmed cell death" EXACT [] +synonym: "retinal programmed cell death" EXACT [] +is_a: GO:0010623 ! programmed cell death involved in cell development +relationship: part_of GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0046667 +name: compound eye retinal cell programmed cell death +namespace: biological_process +def: "Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium." [PMID:12006672] +is_a: GO:0046666 ! retinal cell programmed cell death +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0046668 +name: regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "regulation of retinal programmed cell death" EXACT [GOC:tb] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046669 +name: regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "regulation of retinal cell programmed cell death" BROAD [] +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +relationship: regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046670 +name: positive regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "activation of retinal programmed cell death" NARROW [] +synonym: "positive regulation of retinal programmed cell death" EXACT [GOC:tb] +synonym: "stimulation of retinal programmed cell death" NARROW [] +synonym: "up regulation of retinal programmed cell death" EXACT [] +synonym: "up-regulation of retinal programmed cell death" EXACT [] +synonym: "upregulation of retinal programmed cell death" EXACT [] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046671 +name: negative regulation of retinal cell programmed cell death +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina." [GOC:ai, GOC:tb] +synonym: "down regulation of retinal programmed cell death" EXACT [] +synonym: "down-regulation of retinal programmed cell death" EXACT [] +synonym: "downregulation of retinal programmed cell death" EXACT [] +synonym: "inhibition of retinal programmed cell death" NARROW [] +synonym: "negative regulation of retinal programmed cell death" EXACT [GOC:tb] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0046668 ! regulation of retinal cell programmed cell death +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0046666 ! retinal cell programmed cell death + +[Term] +id: GO:0046672 +name: positive regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "activation of retinal cell programmed cell death" BROAD [] +synonym: "positive regulation of retinal cell programmed cell death" BROAD [] +synonym: "stimulation of retinal cell programmed cell death" BROAD [] +synonym: "up regulation of retinal cell programmed cell death" BROAD [] +synonym: "up-regulation of retinal cell programmed cell death" BROAD [] +synonym: "upregulation of retinal cell programmed cell death" BROAD [] +is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death +is_a: GO:0046670 ! positive regulation of retinal cell programmed cell death +relationship: positively_regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046673 +name: negative regulation of compound eye retinal cell programmed cell death +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina." [GOC:ai] +synonym: "down regulation of retinal cell programmed cell death" BROAD [] +synonym: "down-regulation of retinal cell programmed cell death" BROAD [] +synonym: "downregulation of retinal cell programmed cell death" BROAD [] +synonym: "inhibition of retinal cell programmed cell death" BROAD [] +synonym: "negative regulation of retina cell programmed cell death" BROAD [] +synonym: "negative regulation of retinal cell programmed cell death" BROAD [] +is_a: GO:0046669 ! regulation of compound eye retinal cell programmed cell death +is_a: GO:0046671 ! negative regulation of retinal cell programmed cell death +relationship: negatively_regulates GO:0046667 ! compound eye retinal cell programmed cell death + +[Term] +id: GO:0046676 +name: negative regulation of insulin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin." [GOC:ai] +synonym: "down regulation of insulin secretion" EXACT [] +synonym: "down-regulation of insulin secretion" EXACT [] +synonym: "downregulation of insulin secretion" EXACT [] +synonym: "inhibition of insulin secretion" NARROW [] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0050796 ! regulation of insulin secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0046677 +name: response to antibiotic +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] +subset: goslim_chembl +synonym: "antibiotic susceptibility/resistance" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0046678 +name: response to bacteriocin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [ISBN:0721662544] +synonym: "bacteriocin susceptibility/resistance" RELATED [] +is_a: GO:0046677 ! response to antibiotic +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:0046679 +name: response to streptomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:curators] +synonym: "streptomycin susceptibility/resistance" RELATED [] +is_a: GO:0046677 ! response to antibiotic +is_a: GO:1903416 ! response to glycoside + +[Term] +id: GO:0046680 +name: response to DDT +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals." [ISBN:0721662544] +synonym: "DDT resistance" RELATED [] +synonym: "DDT susceptibility/resistance" RELATED [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046681 +name: response to carbamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase." [ISBN:0721662544] +synonym: "carbamate resistance" RELATED [] +synonym: "carbamate susceptibility/resistance" RELATED [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0017085 ! response to insecticide +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0046682 +name: response to cyclodiene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring." [ISBN:0877797099] +synonym: "cyclodiene resistance" RELATED [] +synonym: "cyclodiene susceptibility/resistance" RELATED [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046683 +name: response to organophosphorus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] +synonym: "organophosphorus resistance" RELATED [] +synonym: "organophosphorus susceptibility/resistance" RELATED [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0046684 +name: response to pyrethroid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage." [ISBN:0721662544] +synonym: "pyrethroid resistance" RELATED [] +synonym: "pyrethroid susceptibility/resistance" RELATED [] +is_a: GO:0017085 ! response to insecticide + +[Term] +id: GO:0046685 +name: response to arsenic-containing substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544] +synonym: "arsenate sensitivity/resistance" RELATED [] +synonym: "response to arsenic" EXACT [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0046686 +name: response to cadmium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] +synonym: "cadmium sensitivity/resistance" RELATED [] +synonym: "response to cadmium" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046687 +name: response to chromate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [ISBN:0721662544] +synonym: "chromate sensitivity/resistance" RELATED [] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0046688 +name: response to copper ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] +synonym: "copper sensitivity/resistance" RELATED [] +synonym: "response to copper" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046689 +name: response to mercury ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] +synonym: "mercuric sensitivity/resistance" RELATED [] +synonym: "response to mercuric ion" NARROW [GOC:mah] +synonym: "response to mercury" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0046690 +name: response to tellurium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:ai] +synonym: "response to tellurium" EXACT [] +synonym: "tellurium sensitivity/resistance" RELATED [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0046691 +name: intracellular canaliculus +namespace: cellular_component +def: "An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." [GOC:mah, ISBN:0721662544, PMID:10700045] +synonym: "canalicular membrane" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0046692 +name: sperm competition +namespace: biological_process +def: "Any process that contributes to the success of sperm fertilization in multiply-mated females." [PMID:10885514] +xref: Wikipedia:Sperm_competition +is_a: GO:0044703 ! multi-organism reproductive process +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0046693 +name: sperm storage +namespace: biological_process +def: "The retention of sperm by a female following mating." [PMID:10885514] +synonym: "retention of sperm" EXACT [] +synonym: "sequestering of sperm" EXACT [] +synonym: "sequestration of sperm" EXACT [] +synonym: "sperm retention" EXACT [] +synonym: "sperm sequestering" EXACT [] +synonym: "sperm sequestration" EXACT [] +synonym: "storage of sperm" EXACT [] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0046694 +name: sperm incapacitation +namespace: biological_process +def: "The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males." [PMID:10440373] +is_a: GO:0046692 ! sperm competition + +[Term] +id: GO:0046695 +name: SLIK (SAGA-like) complex +namespace: cellular_component +def: "A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction." [PMID:33864814] +comment: See also the cellular component term 'SAGA complex ; GO:0000124'. +synonym: "SAGA (alt) complex" EXACT [] +synonym: "SALSA complex" EXACT [] +synonym: "SLIK/SALSA complex" EXACT [] +is_a: GO:0070461 ! SAGA-type complex + +[Term] +id: GO:0046696 +name: lipopolysaccharide receptor complex +namespace: cellular_component +def: "A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens." [PMID:11706042, PMID:9665271] +comment: Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. +synonym: "LPS receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016021 ! integral component of membrane + +[Term] +id: GO:0046697 +name: decidualization +namespace: biological_process +def: "The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta." [ISBN:0721662544, PMID:11133685] +synonym: "decidual cell reaction" EXACT [] +xref: Wikipedia:Decidualization +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0001893 ! maternal placenta development + +[Term] +id: GO:0046700 +name: heterocycle catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] +synonym: "heterocycle breakdown" EXACT [] +synonym: "heterocycle catabolism" EXACT [] +synonym: "heterocycle degradation" EXACT [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0046701 +name: insecticide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects." [GOC:ai] +synonym: "insecticide breakdown" EXACT [] +synonym: "insecticide catabolism" EXACT [] +synonym: "insecticide degradation" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0017143 ! insecticide metabolic process +is_a: GO:0042178 ! xenobiotic catabolic process + +[Term] +id: GO:0046702 +name: galactoside 6-L-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside." [PMID:12413479] +is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity + +[Term] +id: GO:0046703 +name: natural killer cell lectin-like receptor binding +namespace: molecular_function +def: "Binding to a lectin-like natural killer cell receptor." [GOC:ai] +synonym: "KLRC4 receptor binding" NARROW [] +synonym: "NK cell lectin-like receptor binding" EXACT [] +synonym: "NKG2D receptor binding" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0046704 +name: CDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving CDP, cytidine (5'-)diphosphate." [GOC:ai] +synonym: "CDP metabolism" EXACT [] +is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process +is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process + +[Term] +id: GO:0046705 +name: CDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." [GOC:ai] +synonym: "CDP anabolism" EXACT [] +synonym: "CDP biosynthesis" EXACT [] +synonym: "CDP formation" EXACT [] +synonym: "CDP synthesis" EXACT [] +is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process +is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process +is_a: GO:0046704 ! CDP metabolic process + +[Term] +id: GO:0046706 +name: CDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of CDP, cytidine (5'-)diphosphate." [GOC:ai] +synonym: "CDP breakdown" EXACT [] +synonym: "CDP catabolism" EXACT [] +synonym: "CDP degradation" EXACT [] +is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process +is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process +is_a: GO:0046704 ! CDP metabolic process + +[Term] +id: GO:0046707 +name: IDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving IDP, inosine 5'-diphosphate." [GOC:ai] +synonym: "IDP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046708 +name: IDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of IDP, inosine 5'-diphosphate." [GOC:ai] +synonym: "IDP anabolism" EXACT [] +synonym: "IDP biosynthesis" EXACT [] +synonym: "IDP formation" EXACT [] +synonym: "IDP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0046709 +name: IDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of IDP, inosine 5'-diphosphate." [GOC:ai] +synonym: "IDP breakdown" EXACT [] +synonym: "IDP catabolism" EXACT [] +synonym: "IDP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046707 ! IDP metabolic process + +[Term] +id: GO:0046710 +name: GDP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate." [GOC:ai] +synonym: "GDP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process + +[Term] +id: GO:0046711 +name: GDP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP, guanosine 5'-diphosphate." [GOC:ai] +synonym: "GDP anabolism" EXACT [] +synonym: "GDP biosynthesis" EXACT [] +synonym: "GDP formation" EXACT [] +synonym: "GDP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process +is_a: GO:0046710 ! GDP metabolic process + +[Term] +id: GO:0046712 +name: GDP catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of GDP, guanosine 5'-diphosphate." [GOC:ai] +synonym: "GDP breakdown" EXACT [] +synonym: "GDP catabolism" EXACT [] +synonym: "GDP degradation" EXACT [] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0009181 ! purine ribonucleoside diphosphate catabolic process +is_a: GO:0046710 ! GDP metabolic process + +[Term] +id: GO:0046713 +name: borate transport +namespace: biological_process +def: "The directed movement of borate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals." [PMID:21710975] +synonym: "boron transport" RELATED [] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0046714 +name: borate binding +namespace: molecular_function +def: "Binding to borate, the anion (BO3)3-." [GOC:curators] +synonym: "boron binding" RELATED [] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0046715 +name: active borate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0080138 +def: "Enables the transport of borate across a membrane against the concentration gradient." [PMID:12447444] +synonym: "borate transmembrane transporter activity" BROAD [] +synonym: "borate uptake transmembrane transporter activity" RELATED [] +synonym: "boron transmembrane transporter activity" RELATED [] +synonym: "boron uptake transmembrane transporter activity" RELATED [] +synonym: "efflux-type borate transporter" NARROW [] +synonym: "efflux-type boron transporter" RELATED [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0046716 +name: muscle cell cellular homeostasis +namespace: biological_process +def: "The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state." [GOC:mah, PMID:3091429, PMID:7781901] +synonym: "muscle fiber maintenance" NARROW [GOC:dph, GOC:tb] +synonym: "muscle homeostasis" RELATED [GOC:dph] +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0046717 +name: acid secretion +namespace: biological_process +def: "The controlled release of acid by a cell or a tissue." [GOC:ai] +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0046718 +name: viral entry into host cell +namespace: biological_process +alt_id: GO:0019063 +def: "The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm." [GOC:jl] +comment: Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location. +subset: goslim_metagenomics +synonym: "entry of virus into host cell" EXACT [] +synonym: "phage translocation" EXACT [] +synonym: "viral penetration" EXACT [] +synonym: "virion penetration" EXACT [] +synonym: "virion penetration into host cell" EXACT [] +synonym: "virus entry into host cell" EXACT [GOC:bf] +xref: VZ:936 +is_a: GO:0044409 ! entry into host +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0046719 +name: regulation by virus of viral protein levels in host cell +namespace: biological_process +def: "Any virus-mediated process that modulates the levels of viral proteins in a cell." [GOC:ai] +synonym: "regulation of viral protein levels" EXACT [] +is_a: GO:0048878 ! chemical homeostasis +is_a: GO:0050792 ! regulation of viral process + +[Term] +id: GO:0046720 +name: citric acid secretion +namespace: biological_process +def: "The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue." [GOC:ai] +synonym: "citrate secretion" EXACT [] +is_a: GO:0015746 ! citrate transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046721 +name: formic acid secretion +namespace: biological_process +def: "The controlled release of formic acid, HCOOH, by a cell or a tissue." [GOC:ai] +synonym: "formate secretion" EXACT [] +is_a: GO:0015724 ! formate transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046722 +name: lactic acid secretion +namespace: biological_process +def: "The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue." [GOC:ai] +synonym: "lactate secretion" EXACT [] +is_a: GO:0035879 ! plasma membrane lactate transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046723 +name: malic acid secretion +namespace: biological_process +def: "The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue." [GOC:ai] +synonym: "hydroxysuccinic acid secretion" EXACT [] +synonym: "malate secretion" EXACT [] +is_a: GO:0015743 ! malate transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046724 +name: oxalic acid secretion +namespace: biological_process +def: "The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue." [GOC:ai] +synonym: "oxalate secretion" EXACT [] +is_a: GO:0019532 ! oxalate transport +is_a: GO:0046717 ! acid secretion + +[Term] +id: GO:0046725 +name: negative regulation by virus of viral protein levels in host cell +namespace: biological_process +def: "Any process where the infecting virus reduces the levels of viral proteins in a cell." [GOC:ai] +synonym: "down regulation of viral protein levels in host cell" EXACT [] +synonym: "down-regulation of viral protein levels in host cell" EXACT [] +synonym: "downregulation of viral protein levels in host cell" EXACT [] +synonym: "inhibition of viral protein levels in host cell" NARROW [] +synonym: "negative regulation of viral protein levels" EXACT [] +is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell +is_a: GO:0048525 ! negative regulation of viral process + +[Term] +id: GO:0046726 +name: positive regulation by virus of viral protein levels in host cell +namespace: biological_process +def: "Any process where the infecting virus increases the levels of viral proteins in a cell." [GOC:ai] +synonym: "activation of viral protein levels in host cell" NARROW [] +synonym: "positive regulation of viral protein levels" EXACT [] +synonym: "stimulation of viral protein levels in host cell" NARROW [] +synonym: "up regulation of viral protein levels in host cell" EXACT [] +synonym: "up-regulation of viral protein levels in host cell" EXACT [] +synonym: "upregulation of viral protein levels in host cell" EXACT [] +is_a: GO:0046719 ! regulation by virus of viral protein levels in host cell +is_a: GO:0048524 ! positive regulation of viral process + +[Term] +id: GO:0046727 +name: capsomere +namespace: cellular_component +def: "Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses." [ISBN:0198506732] +synonym: "capsomer" EXACT [] +xref: Wikipedia:Capsomere +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046729 +name: viral procapsid +namespace: cellular_component +def: "A stable empty viral capsid produced during the assembly of viruses." [ISBN:0072370319, ISBN:1555811272] +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0046730 +name: induction by virus of host immune response +namespace: biological_process +alt_id: GO:0046731 +alt_id: GO:0046732 +alt_id: GO:0046733 +alt_id: GO:0046734 +alt_id: GO:0046735 +def: "The induction by a virus of an immune response in the host organism." [GOC:jl] +synonym: "activation of host immune response by virus" EXACT [] +synonym: "active induction of host immune response by virus" RELATED [] +synonym: "active viral induction of host immune response" RELATED [] +synonym: "passive activation of host immune response by virus" NARROW [] +synonym: "passive induction of cell-mediated immune response in host by virus" NARROW [] +synonym: "passive induction of host cell-mediated immune response by virus" NARROW [] +synonym: "passive induction of host humoral immune response by virus" NARROW [] +synonym: "passive induction of host immune response by virus" NARROW [] +synonym: "passive induction of host innate immune response by virus" NARROW [] +synonym: "passive induction of humoral immune response in host by virus" NARROW [] +synonym: "passive induction of innate immune response in host by virus" NARROW [] +synonym: "passive viral activation of cell-mediated immune response in host" NARROW [] +synonym: "passive viral activation of humoral immune response in host" NARROW [] +synonym: "passive viral activation of innate immune response in host" NARROW [] +synonym: "passive viral induction of cell-mediated immune response in host" NARROW [] +synonym: "passive viral induction of host immune response" NARROW [] +synonym: "passive viral induction of humoral immune response in host" NARROW [] +synonym: "passive viral induction of innate immune response in host" NARROW [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0075528 ! modulation by virus of host immune response + +[Term] +id: GO:0046736 +name: induction of humoral immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of a host humoral defense response to viral infection." [GOC:jl] +synonym: "active induction of humoral immune response in host by virus" RELATED [] +synonym: "active viral induction of humoral immune response in host" EXACT [] +is_a: GO:0046730 ! induction by virus of host immune response + +[Term] +id: GO:0046737 +name: induction of cell-mediated immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection." [GOC:jl] +synonym: "active induction of cell-mediated immune response in host by virus" RELATED [] +synonym: "active viral induction of cell-mediated immune response in host" EXACT [] +is_a: GO:0046730 ! induction by virus of host immune response + +[Term] +id: GO:0046738 +name: induction of innate immune response in host by virus +namespace: biological_process +def: "The intentional, virally-encoded stimulation of an innate host defense response to viral infection." [GOC:jl] +synonym: "active induction of innate immune response in host by virus" RELATED [] +synonym: "active viral induction of innate immune response in host" EXACT [] +is_a: GO:0046730 ! induction by virus of host immune response + +[Term] +id: GO:0046739 +name: transport of virus in multicellular host +namespace: biological_process +def: "The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs)." [GOC:bf, GOC:jl, ISBN:0781718325] +synonym: "spread of virus in multicellular host" RELATED [GOC:bf, GOC:jl] +synonym: "spread of virus within multicellular host" EXACT [] +synonym: "viral spread within multicellular host" EXACT [] +is_a: GO:0044000 ! movement in host +is_a: GO:0046794 ! transport of virus + +[Term] +id: GO:0046740 +name: transport of virus in host, cell to cell +namespace: biological_process +def: "The transport of a virus between adjacent cells in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325] +synonym: "cell to cell spread of virus within host" EXACT [] +synonym: "intercellular virus transport" EXACT [GOC:bf, GOC:jl] +synonym: "spread of virus in host, cell to cell" RELATED [GOC:bf, GOC:jl] +synonym: "spread of virus within host, cell to cell" EXACT [] +synonym: "viral spread within host, cell to cell" EXACT [] +xref: VZ:1018 +is_a: GO:0046739 ! transport of virus in multicellular host + +[Term] +id: GO:0046741 +name: transport of virus in host, tissue to tissue +namespace: biological_process +def: "The transport of a virus between tissues in a multicellular organism." [GOC:bf, GOC:jl, ISBN:0781718325] +synonym: "spread of virus in host, tissue to tissue" RELATED [GOC:bf, GOC:jl] +synonym: "spread of virus within host, tissue to tissue" EXACT [] +synonym: "tissue to tissue spread of virus within host" EXACT [] +synonym: "viral spread within host, tissue to tissue" EXACT [] +is_a: GO:0046739 ! transport of virus in multicellular host + +[Term] +id: GO:0046745 +name: viral capsid secondary envelopment +namespace: biological_process +alt_id: GO:0046746 +alt_id: GO:0046747 +alt_id: GO:0046748 +alt_id: GO:0046768 +alt_id: GO:0046769 +alt_id: GO:0046770 +def: "The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope." [ISBN:0072370319, ISBN:0781718325, PMID:11533156] +synonym: "endoplasmic reticulum membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "ER membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "Golgi membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "inner nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "nuclear membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "outer nuclear membrane viral budding during viral capsid re-envelopment" EXACT [] +synonym: "plasma membrane viral budding during viral capsid re-envelopment" RELATED [] +synonym: "viral budding from ER membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from ER membrane during viral capsid re-envelopment" RELATED [] +synonym: "viral budding from Golgi membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from Golgi membrane during viral capsid re-envelopment" RELATED [] +synonym: "viral budding from inner nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [] +synonym: "viral budding from nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from nuclear membrane during viral capsid re-envelopment" RELATED [] +synonym: "viral budding from outer nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from outer nuclear membrane during viral capsid re-envelopment" EXACT [] +synonym: "viral budding from plasma membrane by viral capsid re-envelopment" EXACT [] +synonym: "viral budding from plasma membrane during viral capsid re-envelopment" RELATED [] +synonym: "viral capsid re-envelopment" RELATED [GOC:bf, GOC:jl] +synonym: "virus budding from ER membrane by viral capsid re-envelopment" EXACT [] +synonym: "virus budding from ER membrane during viral capsid re-envelopment" RELATED [GOC:tb] +synonym: "virus budding from Golgi membrane by viral capsid re-envelopment" EXACT [] +synonym: "virus budding from Golgi membrane during viral capsid re-envelopment" RELATED [GOC:tb] +synonym: "virus budding from inner nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "virus budding from inner nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] +synonym: "virus budding from nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "virus budding from nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] +synonym: "virus budding from outer nuclear membrane by viral capsid re-envelopment" EXACT [] +synonym: "virus budding from outer nuclear membrane during viral capsid re-envelopment" RELATED [GOC:tb] +synonym: "virus budding from plasma membrane during viral capsid re-envelopment" RELATED [GOC:tb] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0046752 +name: viral capsid precursor transport to host cell nucleus +namespace: biological_process +def: "Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid." [ISBN:0781718325] +synonym: "establishment and maintenance of viral capsid precursor localization in nucleus" BROAD [] +synonym: "localization of viral capsid precursors in nucleus" BROAD [] +synonym: "nuclear localization of viral capsid precursors" BROAD [] +synonym: "viral capsid precursor localisation in host cell nucleus" BROAD [GOC:mah] +synonym: "viral capsid precursor localization in host cell nucleus" BROAD [] +synonym: "viral capsid precursor localization to host cell nucleus" BROAD [GOC:bf, GOC:jl] +is_a: GO:0030581 ! symbiont intracellular protein transport in host +is_a: GO:0042000 ! translocation of peptides or proteins into host +relationship: part_of GO:0039708 ! nuclear capsid assembly + +[Term] +id: GO:0046753 +name: non-lytic viral release +namespace: biological_process +def: "The exit of a viral particle from a cell that does not involve cell lysis." [GOC:bf, GOC:jl, ISBN:0072370319] +is_a: GO:0019076 ! viral release from host cell + +[Term] +id: GO:0046754 +name: viral exocytosis +namespace: biological_process +def: "The exit of enveloped or unenveloped virion particles from the host cell by exocytosis, without causing cell lysis." [ISBN:0072370319] +is_a: GO:0046753 ! non-lytic viral release + +[Term] +id: GO:0046755 +name: viral budding +namespace: biological_process +alt_id: GO:0046744 +def: "A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space." [ISBN:0781718325, VZ:1947] +synonym: "viral capsid envelopment" RELATED [] +synonym: "virion budding" NARROW [] +synonym: "virus budding" RELATED [] +xref: VZ:1947 "Viral budding" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0046757 +name: obsolete lytic virus budding from ER membrane +namespace: biological_process +def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host endoplasmic reticulum membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +comment: This term was made obsolete because it does not appear to correspond to a real biological process. +synonym: "lytic endoplasmic reticulum membrane viral budding" EXACT [] +synonym: "lytic ER membrane viral budding" EXACT [] +synonym: "lytic viral budding from ER membrane" EXACT [] +synonym: "lytic virus budding from ER membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046758 +name: obsolete lytic virus budding from Golgi membrane +namespace: biological_process +def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host Golgi membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +comment: This term was made obsolete because it does not appear to correspond to a real biological process. +synonym: "lytic Golgi membrane viral budding" EXACT [] +synonym: "lytic viral budding from Golgi membrane" EXACT [] +synonym: "lytic virus budding from Golgi membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046759 +name: obsolete lytic virus budding from plasma membrane +namespace: biological_process +def: "OBSOLETE. A form of viral release in which the nucleocapsid evaginates from the host nuclear membrane system, resulting in envelopment of the virus and cell lysis." [ISBN:0072370319] +comment: This term was made obsolete because it does not appear to correspond to a real biological process. +synonym: "lytic plasma membrane viral budding" EXACT [] +synonym: "lytic viral budding from plasma membrane" EXACT [] +synonym: "lytic virus budding from plasma membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046760 +name: viral budding from Golgi membrane +namespace: biological_process +alt_id: GO:0046750 +alt_id: GO:0046763 +def: "A viral budding that starts with formation of a membrane curvature in the host Golgi membrane." [GOC:bf, ISBN:0072370319, VZ:1947] +synonym: "Golgi membrane viral budding" EXACT [] +synonym: "Golgi membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from Golgi membrane by viral capsid envelopment" RELATED [] +synonym: "viral budding from Golgi membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from Golgi membrane" EXACT [] +synonym: "virus budding from Golgi membrane by viral capsid envelopment" RELATED [] +synonym: "virus budding from Golgi membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046755 ! viral budding + +[Term] +id: GO:0046761 +name: viral budding from plasma membrane +namespace: biological_process +alt_id: GO:0046766 +alt_id: GO:0046767 +def: "A viral budding that starts with formation of a membrane curvature in the host plasma membrane." [GOC:bf, ISBN:0072370319, PMID:9394621, VZ:1947] +synonym: "plasma membrane viral budding" EXACT [] +synonym: "plasma membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from plasma membrane by viral capsid envelopment" RELATED [] +synonym: "viral budding from plasma membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from plasma membrane" EXACT [] +synonym: "virus budding from plasma membrane by viral capsid envelopment" EXACT [] +synonym: "virus budding from plasma membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046753 ! non-lytic viral release +is_a: GO:0046755 ! viral budding + +[Term] +id: GO:0046762 +name: viral budding from endoplasmic reticulum membrane +namespace: biological_process +alt_id: GO:0046751 +alt_id: GO:0046764 +def: "A viral budding that starts with formation of a membrane curvature in the host ER membrane." [GOC:bf, GOC:jl, ISBN:0072370319, VZ:1947] +synonym: "endoplasmic reticulum membrane viral budding" EXACT [] +synonym: "endoplasmic reticulum membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "ER membrane viral budding" EXACT [] +synonym: "ER membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from ER membrane" EXACT [] +synonym: "viral budding from ER membrane by viral capsid envelopment" RELATED [] +synonym: "viral budding from ER membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from ER membrane" EXACT [] +synonym: "virus budding from ER membrane by viral capsid envelopment" EXACT [] +synonym: "virus budding from ER membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046755 ! viral budding + +[Term] +id: GO:0046765 +name: viral budding from nuclear membrane +namespace: biological_process +alt_id: GO:0046749 +def: "A viral budding that starts with formation of a membrane curvature in the host nuclear membrane." [GOC:bf, ISBN:0072370319] +synonym: "nuclear membrane viral budding" EXACT [] +synonym: "nuclear membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from nuclear membrane by viral capsid envelopment" RELATED [] +synonym: "viral budding from nuclear membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from nuclear membrane" EXACT [] +synonym: "virus budding from nuclear membrane by viral capsid envelopment" EXACT [] +synonym: "virus budding from nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046755 ! viral budding +relationship: part_of GO:0046802 ! exit of virus from host cell nucleus by nuclear egress + +[Term] +id: GO:0046771 +name: viral budding from inner nuclear membrane +namespace: biological_process +def: "The envelopment of a virus, in which the nucleocapsid evaginates from the host inner nuclear membrane system into the perinuclear space, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "inner nuclear membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from inner nuclear membrane by viral capsid envelopment" RELATED [] +synonym: "viral budding from inner nuclear membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from inner nuclear membrane by viral capsid envelopment" EXACT [] +synonym: "virus budding from inner nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046765 ! viral budding from nuclear membrane + +[Term] +id: GO:0046772 +name: viral budding from outer nuclear membrane +namespace: biological_process +def: "The envelopment of a virus, in which the naked capsid evaginates from the host outer nuclear membrane system, thus acquiring a membrane envelope." [ISBN:0072370319] +synonym: "outer nuclear membrane viral budding during viral capsid envelopment" RELATED [] +synonym: "viral budding from outer nuclear membrane during viral capsid envelopment" RELATED [] +synonym: "virus budding from outer nuclear membrane by viral capsid envelopment" EXACT [] +synonym: "virus budding from outer nuclear membrane during viral capsid envelopment" RELATED [GOC:tb] +is_a: GO:0046765 ! viral budding from nuclear membrane + +[Term] +id: GO:0046773 +name: suppression by virus of host translation termination +namespace: biological_process +def: "Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA." [ISBN:0781718325] +synonym: "negative regulation by virus of host cell protein biosynthesis shutoff" EXACT [] +synonym: "negative regulation by virus of host cell protein biosynthetic process shutoff" EXACT [] +synonym: "suppression by virus of host termination of protein biosynthetic process" RELATED [] +synonym: "viral inhibition of host cell protein biosynthesis shutoff" EXACT [] +synonym: "viral inhibition of host cell protein biosynthetic process shutoff" EXACT [] +synonym: "viral inhibition of termination of host cell protein biosynthesis" EXACT [] +synonym: "viral inhibition of termination of host cell protein biosynthetic process" EXACT [] +synonym: "viral suppression of termination by host of host cell protein biosynthesis" EXACT [] +synonym: "viral suppression of termination by host of host cell protein biosynthetic process" EXACT [] +is_a: GO:0019057 ! modulation by virus of host translation + +[Term] +id: GO:0046774 +name: suppression by virus of host intracellular interferon activity +namespace: biological_process +def: "Any viral process that results in the inhibition of interferon activity within the host cell." [PMID:10859382] +synonym: "negative regulation by virus of intracellular interferon activity" EXACT [] +synonym: "suppression by virus of intracellular interferon activity in host" EXACT [] +is_a: GO:0030683 ! mitigation of host immune response by virus +is_a: GO:0075528 ! modulation by virus of host immune response + +[Term] +id: GO:0046775 +name: suppression by virus of host cytokine production +namespace: biological_process +def: "Any viral process that results in the inhibition of host cell cytokine production." [PMID:10859382] +synonym: "negative regulation by virus of host cytokine production" EXACT [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0044831 ! modulation by virus of host cytokine production +is_a: GO:0050776 ! regulation of immune response +is_a: GO:0050794 ! regulation of cellular process + +[Term] +id: GO:0046776 +name: suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I +namespace: biological_process +alt_id: GO:0039591 +def: "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [GOC:add, GOC:bf, PMID:10859382] +synonym: "inhibition of host MHC class I molecule presentation by virus" EXACT [] +synonym: "negative regulation by virus of MHC class I cell surface presentation" EXACT [] +synonym: "suppression by virus of host MHC class I cell surface presentation" EXACT [GOC:add] +synonym: "suppression by virus of host tapasin activity" NARROW [] +synonym: "suppression by virus of MHC class I cell surface presentation in host" EXACT [] +is_a: GO:0039588 ! suppression by virus of host antigen processing and presentation +relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I + +[Term] +id: GO:0046777 +name: protein autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] +synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf] +xref: Wikipedia:Autophosphorylation +is_a: GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0046778 +name: modification by virus of host mRNA processing +namespace: biological_process +def: "Any viral process that interferes with the processing of mRNA in the host cell." [ISBN:0781718325] +synonym: "viral perturbation of host mRNA processing" EXACT [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0039656 ! modulation by virus of host gene expression +is_a: GO:0050684 ! regulation of mRNA processing + +[Term] +id: GO:0046779 +name: obsolete suppression by virus of expression of host genes with introns +namespace: biological_process +def: "OBSOLETE. Any viral process that discriminates against and subsequently inhibits host transcripts containing introns, thus allowing only intronless viral mRNA to be fully processed." [PMID:11598019] +comment: The reason for obsoleting this term is that it is too specific. +synonym: "negative regulation by virus of expression of host genes with introns" EXACT [] +synonym: "viral inhibition of expression of host genes with introns" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046780 +name: suppression by virus of host mRNA splicing +namespace: biological_process +alt_id: GO:0046781 +def: "Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production." [ISBN:0781718325, PMID:19729513] +synonym: "negative regulation by virus of host mRNA splicing" EXACT [] +synonym: "suppression by virus of host splicing factor activity" EXACT [] +synonym: "viral dispersion of host splicing factors" EXACT [] +synonym: "viral inhibition of host mRNA splicing" EXACT [] +is_a: GO:0033119 ! negative regulation of RNA splicing +is_a: GO:0039524 ! suppression by virus of host mRNA processing + +[Term] +id: GO:0046782 +name: regulation of viral transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the transcription of the viral genome." [GOC:ai] +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0046783 +name: modification by virus of host polysomes +namespace: biological_process +def: "Any viral process that interferes with and inhibits the assembly and function of polysomes." [PMID:10438802] +comment: See also the cellular component term 'polysome ; GO:0005844'. +synonym: "viral perturbation of polysomes" EXACT [] +is_a: GO:0019057 ! modulation by virus of host translation + +[Term] +id: GO:0046784 +name: viral mRNA export from host cell nucleus +namespace: biological_process +def: "The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation." [PMID:11598019] +synonym: "intronless viral mRNA export from host cell nucleus" EXACT [] +synonym: "intronless viral mRNA export from host nucleus" RELATED [] +synonym: "intronless viral mRNA export out of nucleus" EXACT [] +synonym: "intronless viral mRNA transport from nucleus to cytoplasm" EXACT [] +synonym: "intronless viral mRNA-nucleus export" EXACT [] +is_a: GO:0044417 ! translocation of molecules into host + +[Term] +id: GO:0046785 +name: microtubule polymerization +namespace: biological_process +def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] +synonym: "microtubule assembly" EXACT [] +synonym: "microtubule formation" RELATED [] +is_a: GO:0031109 ! microtubule polymerization or depolymerization +is_a: GO:0051258 ! protein polymerization +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0046786 +name: viral replication complex formation and maintenance +namespace: biological_process +def: "The process of organizing and assembling viral replication proteins in preparation for viral replication." [ISBN:0781718325] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019079 ! viral genome replication + +[Term] +id: GO:0046787 +name: viral DNA repair +namespace: biological_process +def: "The process of restoring viral DNA after damage or errors in replication." [ISBN:0781718325] +is_a: GO:0006281 ! DNA repair +relationship: part_of GO:0016032 ! viral process + +[Term] +id: GO:0046789 +name: host cell surface receptor binding +namespace: molecular_function +def: "Binding to a receptor on the host cell surface." [GOC:ai, PMID:11511370] +subset: goslim_chembl +synonym: "cell surface antigen activity, host-interacting" RELATED [] +synonym: "cell surface receptor ligand" RELATED [] +is_a: GO:0046812 ! host cell surface binding + +[Term] +id: GO:0046790 +name: virion binding +namespace: molecular_function +def: "Binding to a virion, either by binding to components of the capsid or the viral envelope." [GOC:ai] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046791 +name: obsolete suppression by virus of host complement neutralization +namespace: biological_process +def: "OBSOLETE. Any viral process that results in the inhibition of complement neutralization of the host cell." [PMID:10587354] +comment: This term was made obsolete because the meaning of the term is unclear. It most likely refers to inhibiting the process by which a virus particle is neutralized by the host cell in a complement-dependent manner. +synonym: "negative regulation by virus of host complement neutralization" EXACT [] +synonym: "suppression by virus of host complement neutralization" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046792 +name: suppression by virus of host cell cycle arrest +namespace: biological_process +def: "Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur." [PMID:9371605] +synonym: "negative regulation by virus of cell cycle arrest" EXACT [] +synonym: "viral inhibition of cell cycle arrest" EXACT [] +is_a: GO:0019055 ! modification by virus of host cell cycle regulation + +[Term] +id: GO:0046793 +name: induction by virus of phosphorylation of host RNA polymerase II +namespace: biological_process +def: "Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II." [PMID:7637000] +synonym: "induction by virus of modification of host RNA polymerase II" BROAD [GOC:bf, GOC:jl] +synonym: "virus-induced modification of host RNA polymerase II" EXACT [] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0019056 ! modulation by virus of host transcription +is_a: GO:0039614 ! induction by virus of host protein phosphorylation + +[Term] +id: GO:0046794 +name: transport of virus +namespace: biological_process +def: "The directed movement of a virus, or part of a virus, into, out of, or within a host cell." [GOC:ai] +subset: goslim_pir +synonym: "viral transport" EXACT [GOC:bf, GOC:jl] +synonym: "virion transport" NARROW [GOC:bf, GOC:jl] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0046797 +name: viral procapsid maturation +namespace: biological_process +def: "The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure." [GOC:bf, PMID:10627558, PMID:19204733] +synonym: "capsid maturation" EXACT [] +synonym: "viral capsid maturation" EXACT [PMID:19204733] +synonym: "virion maturation" BROAD [UniProtKB-KW:KW-0917] +xref: UniProtKB-KW:KW-1273 +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0019069 ! viral capsid assembly +relationship: part_of GO:0019075 ! virus maturation + +[Term] +id: GO:0046798 +name: viral portal complex +namespace: cellular_component +def: "A multimeric ring of proteins through which the DNA enters and exits the viral capsid." [PMID:11602732] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046799 +name: recruitment of helicase-primase complex to DNA lesions +namespace: biological_process +def: "The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair." [ISBN:0781718325] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0046787 ! viral DNA repair + +[Term] +id: GO:0046800 +name: obsolete enhancement of virulence +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the severity of viral infection and subsequent disease." [PMID:10587354] +comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. +synonym: "enhancement of virulence" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046802 +name: exit of virus from host cell nucleus by nuclear egress +namespace: biological_process +alt_id: GO:0039676 +def: "The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm." [PMID:21494278, PMID:22858153, PMID:9601512, PMID:9765421, VZ:1952] +synonym: "capsid egress" EXACT [VZ:2177] +synonym: "egress of viral procapsid from host cell nucleus" RELATED [] +synonym: "nuclear egress" EXACT [PMID:22858153] +synonym: "nuclear egress of viral procapsid" EXACT [] +xref: VZ:1952 "Nuclear egress" +is_a: GO:0039674 ! exit of virus from host cell nucleus + +[Term] +id: GO:0046803 +name: obsolete reduction of virulence +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the severity of viral infection and subsequent disease." [PMID:10982346] +comment: This term was made obsolete because 'virulence' is not a biological process; however, alteration of virulence also does not fit under 'regulation of biological quality ; GO:0065008' because it is a product both of the genotype/phenotype of the infecting organism and the genotype/phenotype of the organism being infected and varies by individual within a species both for the infecting organism and the infected organism. +synonym: "reduction of virulence" EXACT [] +is_obsolete: true + +[Term] +id: GO:0046804 +name: peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide +namespace: biological_process +def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine." [RESID:AA0330] +synonym: "peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide" EXACT [] +xref: RESID:AA0330 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046805 +name: protein-heme linkage via 1'-L-histidine +namespace: biological_process +def: "The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine)." [RESID:AA0329] +synonym: "protein-haem linkage via 1'-L-histidine" EXACT [] +xref: RESID:AA0329 +is_a: GO:0017003 ! protein-heme linkage +is_a: GO:0017004 ! cytochrome complex assembly + +[Term] +id: GO:0046806 +name: viral scaffold +namespace: cellular_component +def: "A complex of proteins that form a scaffold around which the viral capsid is constructed." [ISBN:0072370319] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0046807 +name: viral scaffold assembly and maintenance +namespace: biological_process +def: "The assembly and maintenance of the viral scaffold around which the viral capsid is constructed." [ISBN:0072370319] +comment: See also the cellular component term 'viral scaffold ; GO:0046806'. +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019069 ! viral capsid assembly + +[Term] +id: GO:0046808 +name: obsolete assemblon +namespace: cellular_component +def: "OBSOLETE. Antigenically dense structures located at the periphery of nuclei, close to but not abutting nuclear membranes. Assemblons contain the proteins for immature-capsid assembly; they are located at the periphery of a diffuse structure composed of proteins involved in DNA synthesis, which overlaps only minimally with the assemblons. More than one site can be present simultaneously." [PMID:8676489] +comment: This term was obsoleted because it does not correspond to a real cellular component, but to a site of immunoreactivity. +is_obsolete: true + +[Term] +id: GO:0046809 +name: replication compartment +namespace: cellular_component +def: "Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously." [PMID:9499108, VZ:1951] +synonym: "RC" EXACT [VZ:1951] +is_a: GO:0039715 ! nuclear viral factory + +[Term] +id: GO:0046810 +name: host cell extracellular matrix binding +namespace: molecular_function +def: "Binding to the extracellular matrix of a host cell." [PMID:7996163] +is_a: GO:0050840 ! extracellular matrix binding + +[Term] +id: GO:0046811 +name: histone deacetylase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [GOC:ai, PMID:10482575] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0035033 ! histone deacetylase regulator activity + +[Term] +id: GO:0046812 +name: host cell surface binding +namespace: molecular_function +def: "Binding to the surface of a host cell." [GOC:ai] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046813 +name: receptor-mediated virion attachment to host cell +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface." [ISBN:0879694971] +synonym: "virion attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] +is_a: GO:0019062 ! virion attachment to host cell + +[Term] +id: GO:0046814 +name: coreceptor-mediated virion attachment to host cell +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface." [ISBN:0879694971] +synonym: "virion attachment, binding of host cell surface coreceptor" EXACT [GOC:bf, GOC:jl] +is_a: GO:0019062 ! virion attachment to host cell + +[Term] +id: GO:0046815 +name: genome retention in viral capsid +namespace: biological_process +def: "Any process in which the viral genome is retained within the capsid during genome cleavage and packaging." [PMID:9696839] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019079 ! viral genome replication + +[Term] +id: GO:0046816 +name: virion transport vesicle +namespace: cellular_component +def: "A vesicle used to transport the partial or complete virion between cellular compartments." [GOC:vesicles, PMID:7933124] +is_a: GO:0097708 ! intracellular vesicle + +[Term] +id: GO:0046817 +name: chemokine receptor antagonist activity +namespace: molecular_function +def: "Interacts with chemokine receptors to reduce the action of a chemokine." [GOC:ai, ISBN:0781718325] +is_a: GO:0048019 ! receptor antagonist activity + +[Term] +id: GO:0046818 +name: dense nuclear body +namespace: cellular_component +def: "A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously." [PMID:10233976] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0046819 +name: protein secretion by the type V secretion system +namespace: biological_process +def: "The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway." [GOC:pamgo_curators] +synonym: "autotransporter system" EXACT [] +synonym: "protein secretion by the autotransporter system" EXACT [] +synonym: "protein secretion by the type V protein secretion system" EXACT [] +synonym: "type V protein secretion system" EXACT [] +is_a: GO:0009306 ! protein secretion +is_a: GO:0098776 ! protein transport across the cell outer membrane + +[Term] +id: GO:0046820 +name: 4-amino-4-deoxychorismate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate." [EC:2.6.1.85, RHEA:11672] +comment: Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. +synonym: "ADC synthase activity" RELATED [EC:2.6.1.85] +synonym: "aminodeoxychorismate synthase activity" RELATED [] +synonym: "chorismate:L-glutamine amido-ligase activity" RELATED [EC:2.6.1.85] +synonym: "p-aminobenzoate synthetase" RELATED [] +synonym: "PabB activity" RELATED [EC:2.6.1.85] +synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] +synonym: "para-aminobenzoic acid synthase activity" RELATED [] +xref: EC:2.6.1.85 +xref: KEGG_REACTION:R01716 +xref: MetaCyc:PABASYN-RXN +xref: RHEA:11672 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0046821 +name: extrachromosomal DNA +namespace: cellular_component +def: "DNA structures that are not part of a chromosome." [GOC:ai] +xref: Wikipedia:Extrachromosomal_DNA +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0046822 +name: regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046823 +name: negative regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] +synonym: "down regulation of nucleocytoplasmic transport" EXACT [] +synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "downregulation of nucleocytoplasmic transport" EXACT [] +synonym: "inhibition of nucleocytoplasmic transport" NARROW [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046824 +name: positive regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +synonym: "activation of nucleocytoplasmic transport" NARROW [] +synonym: "stimulation of nucleocytoplasmic transport" NARROW [] +synonym: "up regulation of nucleocytoplasmic transport" EXACT [] +synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "upregulation of nucleocytoplasmic transport" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046825 +name: regulation of protein export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of protein export from cell nucleus" EXACT [] +synonym: "regulation of protein export out of nucleus" EXACT [] +synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of protein-nucleus export" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046826 +name: negative regulation of protein export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of protein export from nucleus" EXACT [] +synonym: "down-regulation of protein export from nucleus" EXACT [] +synonym: "downregulation of protein export from nucleus" EXACT [] +synonym: "inhibition of protein export from nucleus" NARROW [] +synonym: "negative regulation of protein export from cell nucleus" EXACT [] +synonym: "negative regulation of protein export out of nucleus" EXACT [] +synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of protein-nucleus export" EXACT [] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0051457 ! maintenance of protein location in nucleus +is_a: GO:0090317 ! negative regulation of intracellular protein transport +relationship: negatively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046827 +name: positive regulation of protein export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of protein export from nucleus" NARROW [] +synonym: "positive regulation of protein export from cell nucleus" EXACT [] +synonym: "positive regulation of protein export out of nucleus" EXACT [] +synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of protein-nucleus export" EXACT [] +synonym: "stimulation of protein export from nucleus" NARROW [] +synonym: "up regulation of protein export from nucleus" EXACT [] +synonym: "up-regulation of protein export from nucleus" EXACT [] +synonym: "upregulation of protein export from nucleus" EXACT [] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0090316 ! positive regulation of intracellular protein transport +relationship: positively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046828 +name: regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] +synonym: "regulation of RNA import into cell nucleus" EXACT [] +synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of RNA-nucleus import" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046829 +name: negative regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "down regulation of RNA import into nucleus" EXACT [] +synonym: "down-regulation of RNA import into nucleus" EXACT [] +synonym: "downregulation of RNA import into nucleus" EXACT [] +synonym: "inhibition of RNA import into nucleus" NARROW [] +synonym: "negative regulation of RNA import into cell nucleus" EXACT [] +synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of RNA-nucleus import" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +relationship: negatively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046830 +name: positive regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "activation of RNA import into nucleus" NARROW [] +synonym: "positive regulation of RNA import into cell nucleus" EXACT [] +synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of RNA-nucleus import" EXACT [] +synonym: "stimulation of RNA import into nucleus" NARROW [] +synonym: "up regulation of RNA import into nucleus" EXACT [] +synonym: "up-regulation of RNA import into nucleus" EXACT [] +synonym: "upregulation of RNA import into nucleus" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +relationship: positively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046831 +name: regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of RNA export from cell nucleus" EXACT [] +synonym: "regulation of RNA export out of nucleus" EXACT [] +synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of RNA-nucleus export" EXACT [] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +relationship: regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046832 +name: negative regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of RNA export from nucleus" EXACT [] +synonym: "down-regulation of RNA export from nucleus" EXACT [] +synonym: "downregulation of RNA export from nucleus" EXACT [] +synonym: "inhibition of RNA export from nucleus" NARROW [] +synonym: "negative regulation of RNA export from cell nucleus" EXACT [] +synonym: "negative regulation of RNA export out of nucleus" EXACT [] +synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of RNA-nucleus export" EXACT [] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +relationship: negatively_regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046833 +name: positive regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of RNA export from nucleus" NARROW [] +synonym: "positive regulation of RNA export from cell nucleus" EXACT [] +synonym: "positive regulation of RNA export out of nucleus" EXACT [] +synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of RNA-nucleus export" EXACT [] +synonym: "stimulation of RNA export from nucleus" NARROW [] +synonym: "up regulation of RNA export from nucleus" EXACT [] +synonym: "up-regulation of RNA export from nucleus" EXACT [] +synonym: "upregulation of RNA export from nucleus" EXACT [] +is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +relationship: positively_regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046834 +name: lipid phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [GOC:bf, ISBN:0198506732] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0046835 +name: carbohydrate phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y." [ISBN:0198506732] +is_a: GO:0016310 ! phosphorylation +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0046836 +name: glycolipid transport +namespace: biological_process +def: "The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0006869 ! lipid transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0046838 +name: phosphorylated carbohydrate dephosphorylation +namespace: biological_process +def: "The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it." [ISBN:0198506732] +is_a: GO:0016311 ! dephosphorylation +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0046839 +name: phospholipid dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents." [ISBN:0198506732] +is_a: GO:0016311 ! dephosphorylation +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0046841 +name: trisporic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota." [GOC:ai] +synonym: "trisporic acid metabolism" EXACT [] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0046842 +name: trisporic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trisporic acid." [GOC:ai] +synonym: "trisporic acid anabolism" EXACT [] +synonym: "trisporic acid biosynthesis" EXACT [] +synonym: "trisporic acid formation" EXACT [] +synonym: "trisporic acid synthesis" EXACT [] +is_a: GO:0046841 ! trisporic acid metabolic process + +[Term] +id: GO:0046843 +name: dorsal appendage formation +namespace: biological_process +def: "Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration." [ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007306 ! eggshell chorion assembly + +[Term] +id: GO:0046844 +name: chorion micropyle formation +namespace: biological_process +def: "Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization." [ISBN:0879694238] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007306 ! eggshell chorion assembly + +[Term] +id: GO:0046845 +name: branched duct epithelial cell fate determination, open tracheal system +namespace: biological_process +def: "Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode." [GOC:mtg_sensu, PMID:10684581] +synonym: "branch cell fate determination" BROAD [] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0046847 +name: filopodium assembly +namespace: biological_process +def: "The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:dph, GOC:mah, GOC:tb, PMID:16337369, PMID:18464790] +synonym: "filopodia biosynthesis" RELATED [] +synonym: "filopodia formation" RELATED [] +synonym: "filopodium formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0046848 +name: hydroxyapatite binding +namespace: molecular_function +def: "Binding to hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin." [PMID:2438276] +synonym: "hydroxylapatite binding" EXACT [GOC:vk] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046849 +name: bone remodeling +namespace: biological_process +def: "The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators] +synonym: "bone remodelling" EXACT [] +xref: Wikipedia:Bone_remodeling +is_a: GO:0048771 ! tissue remodeling + +[Term] +id: GO:0046850 +name: regulation of bone remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity." [GOC:ai] +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046851 +name: negative regulation of bone remodeling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling." [GOC:ai] +synonym: "down regulation of bone remodeling" EXACT [] +synonym: "down-regulation of bone remodeling" EXACT [] +synonym: "downregulation of bone remodeling" EXACT [] +synonym: "inhibition of bone remodeling" NARROW [] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0046850 ! regulation of bone remodeling +relationship: negatively_regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046852 +name: positive regulation of bone remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone remodeling." [GOC:ai] +synonym: "activation of bone remodeling" NARROW [] +synonym: "stimulation of bone remodeling" NARROW [] +synonym: "up regulation of bone remodeling" EXACT [] +synonym: "up-regulation of bone remodeling" EXACT [] +synonym: "upregulation of bone remodeling" EXACT [] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0046850 ! regulation of bone remodeling +relationship: positively_regulates GO:0046849 ! bone remodeling + +[Term] +id: GO:0046853 +name: obsolete inositol or phosphatidylinositol phosphorylation +namespace: biological_process +def: "OBSOLETE. The process of introducing a phosphate group into inositol or a phosphatidylinositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732] +comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. +synonym: "inositol and derivative phosphorylation" RELATED [] +synonym: "inositol or phosphatidylinositol phosphorylation" EXACT [] +synonym: "myo-inositol and derivative phosphorylation" RELATED [] +synonym: "myo-inositol or phosphatidyl-myo-inositol phosphorylation" NARROW [] +is_obsolete: true +consider: GO:0046854 +consider: GO:0052746 + +[Term] +id: GO:0046854 +name: phosphatidylinositol phosphate biosynthetic process +namespace: biological_process +alt_id: GO:0046837 +def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate." [ISBN:0198506732] +synonym: "phosphatidylinositol phosphate biosynthesis" EXACT [] +synonym: "phosphatidylinositol phosphate phosphorylation" NARROW [] +synonym: "phosphatidylinositol phosphorylation" RELATED [] +synonym: "phosphoinositide phosphorylation" NARROW [] +synonym: "PIP biosynthesis" EXACT [] +synonym: "PtdInsP biosynthesis" EXACT [] +is_a: GO:0006661 ! phosphatidylinositol biosynthetic process + +[Term] +id: GO:0046855 +name: inositol phosphate dephosphorylation +namespace: biological_process +def: "The process of removing a phosphate group from any mono- or polyphosphorylated inositol." [ISBN:0198506732] +synonym: "myo-inositol phosphate dephosphorylation" NARROW [] +is_a: GO:0046838 ! phosphorylated carbohydrate dephosphorylation +is_a: GO:0071545 ! inositol phosphate catabolic process + +[Term] +id: GO:0046856 +name: phosphatidylinositol dephosphorylation +namespace: biological_process +alt_id: GO:0046840 +def: "The process of removing one or more phosphate groups from a phosphatidylinositol." [ISBN:0198506732] +synonym: "phosphatidylinositol phosphate catabolic process" NARROW [] +synonym: "phosphatidylinositol phosphate dephosphorylation" NARROW [] +synonym: "phosphoinositide dephosphorylation" EXACT [] +synonym: "PIP catabolism" NARROW [] +synonym: "PtdInsP catabolism" NARROW [] +synonym: "PtdInsP dephosphorylation" NARROW [] +is_a: GO:0046488 ! phosphatidylinositol metabolic process +is_a: GO:0046839 ! phospholipid dephosphorylation + +[Term] +id: GO:0046857 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] +xref: EC:1.7.1.- +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0046858 +name: chlorosome +namespace: cellular_component +def: "A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." [ISBN:0198506732, PMID:14729689, PMID:15298919] +xref: Wikipedia:Chlorosome +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0046859 +name: hydrogenosomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a hydrogenosome." [GOC:ai] +synonym: "hydrogenosome membrane" EXACT [] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0042566 ! hydrogenosome + +[Term] +id: GO:0046860 +name: glycosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a glycosome." [GOC:ai] +is_a: GO:0005778 ! peroxisomal membrane +relationship: part_of GO:0020015 ! glycosome + +[Term] +id: GO:0046861 +name: glyoxysomal membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a glyoxysome." [GOC:ai] +synonym: "glyoxysome membrane" EXACT [] +is_a: GO:0005778 ! peroxisomal membrane +relationship: part_of GO:0009514 ! glyoxysome + +[Term] +id: GO:0046862 +name: chromoplast membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope." [GOC:ai, GOC:mah] +is_a: GO:0042170 ! plastid membrane +relationship: part_of GO:0031898 ! chromoplast envelope + +[Term] +id: GO:0046863 +name: ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity +namespace: molecular_function +alt_id: GO:0018236 +def: "Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate." [PMID:10430961, PMID:10965036, PMID:2404515] +comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. +synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity" EXACT [GOC:dph, GOC:tb] +synonym: "ribulose-bisphosphate carboxylase activase activity" EXACT [] +synonym: "rubisco activase activity" EXACT [] +synonym: "rubisco activator" EXACT [] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0046864 +name: isoprenoid transport +namespace: biological_process +def: "The directed movement of isoprenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Isoprenoids comprise a group of compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:ai] +subset: goslim_pir +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:0046865 +name: terpenoid transport +namespace: biological_process +def: "The directed movement of terpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Terpenoids are a class of compounds characterized by an isoprenoid chemical structure and include derivatives with various functional groups." [GOC:ai] +is_a: GO:0046864 ! isoprenoid transport + +[Term] +id: GO:0046866 +name: tetraterpenoid transport +namespace: biological_process +def: "The directed movement of tetraterpenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetraterpenoids are terpenoids with eight isoprene units." [GOC:ai] +is_a: GO:0046865 ! terpenoid transport + +[Term] +id: GO:0046867 +name: carotenoid transport +namespace: biological_process +def: "The directed movement of carotenoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carotenoids are tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:ai] +is_a: GO:0046866 ! tetraterpenoid transport + +[Term] +id: GO:0046868 +name: mesosome +namespace: cellular_component +def: "An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins." [PMID:31921091, PMID:33327493] +xref: Wikipedia:Mesosome +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0046869 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide." [RESID:AA0331] +synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide" EXACT [] +xref: RESID:AA0331 +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0046870 +name: cadmium ion binding +namespace: molecular_function +def: "Binding to a cadmium ion (Cd)." [GOC:ai] +synonym: "cadmium binding" EXACT [] +synonym: "Cd ion binding" EXACT [] +synonym: "copper/cadmium binding" BROAD [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0046871 +name: N-acetylgalactosamine binding +namespace: molecular_function +def: "Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine." [GOC:ai, PMID:18384150] +synonym: "N-acetylgalactosamine lectin" RELATED [] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0046872 +name: metal ion binding +namespace: molecular_function +def: "Binding to a metal ion." [GOC:ai] +subset: goslim_agr +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +synonym: "heavy metal binding" NARROW [] +synonym: "metal binding" EXACT [] +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0046873 +name: metal ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] +synonym: "heavy metal ion porter activity" NARROW [] +synonym: "heavy metal ion transporter activity" NARROW [] +synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] +synonym: "heavy metal-exporting ATPase activity" NARROW [] +synonym: "high affinity metal ion uptake transporter activity" NARROW [] +synonym: "low affinity metal ion uptake transporter activity" NARROW [] +is_a: GO:0022890 ! inorganic cation transmembrane transporter activity + +[Term] +id: GO:0046874 +name: quinolinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] +synonym: "quinolinate metabolism" EXACT [] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0046875 +name: ephrin receptor binding +namespace: molecular_function +def: "Binding to an ephrin receptor." [GOC:ai] +synonym: "Eph receptor binding" EXACT [] +synonym: "ephrin" NARROW [] +synonym: "GPI-linked ephrin" NARROW [] +synonym: "transmembrane ephrin" NARROW [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0046876 +name: 3,4-didehydroretinal binding +namespace: molecular_function +def: "Binding to 3,4-didehydroretinal, a form of retinal that plays a role in the visual process in freshwater fish and some amphibians analogous to that of all-trans retinal in other vertebrates. 3,4-didehydro-11-cis-retinal combines with an opsin to form cyanopsin (cone) or porphyropsin (rod)." [GOC:ai, ISBN:0198506732] +synonym: "blue-sensitive opsin" NARROW [] +synonym: "green-sensitive opsin" NARROW [] +synonym: "long-wave-sensitive opsin" NARROW [] +synonym: "opsin" NARROW [] +synonym: "red-sensitive opsin" NARROW [] +synonym: "short-wave-sensitive opsin" NARROW [] +synonym: "UV-sensitive opsin" NARROW [] +synonym: "violet-sensitive opsin" NARROW [] +is_a: GO:0005501 ! retinoid binding + +[Term] +id: GO:0046877 +name: regulation of saliva secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue." [GOC:ai] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0046541 ! saliva secretion + +[Term] +id: GO:0046878 +name: positive regulation of saliva secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of saliva." [GOC:ai] +synonym: "activation of saliva secretion" NARROW [] +synonym: "stimulation of saliva secretion" NARROW [] +synonym: "up regulation of saliva secretion" EXACT [] +synonym: "up-regulation of saliva secretion" EXACT [] +synonym: "upregulation of saliva secretion" EXACT [] +is_a: GO:0046877 ! regulation of saliva secretion +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060456 ! positive regulation of digestive system process +relationship: positively_regulates GO:0046541 ! saliva secretion + +[Term] +id: GO:0046879 +name: hormone secretion +namespace: biological_process +def: "The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells." [ISBN:0198506732] +is_a: GO:0009914 ! hormone transport +is_a: GO:0023061 ! signal release + +[Term] +id: GO:0046880 +name: regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +synonym: "regulation of follicle stimulating hormone secretion" EXACT [] +synonym: "regulation of FSH secretion" EXACT [] +is_a: GO:0032276 ! regulation of gonadotropin secretion +relationship: regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046881 +name: positive regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +synonym: "activation of follicle-stimulating hormone secretion" NARROW [] +synonym: "positive regulation of follicle stimulating hormone secretion" EXACT [] +synonym: "stimulation of follicle-stimulating hormone secretion" NARROW [] +synonym: "up regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "up-regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "upregulation of follicle-stimulating hormone secretion" EXACT [] +is_a: GO:0032278 ! positive regulation of gonadotropin secretion +is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion +relationship: positively_regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046882 +name: negative regulation of follicle-stimulating hormone secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of follicle-stimulating hormone." [GOC:ai] +synonym: "down regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "down-regulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "downregulation of follicle-stimulating hormone secretion" EXACT [] +synonym: "inhibition of follicle-stimulating hormone secretion" NARROW [] +synonym: "negative regulation of follicle stimulating hormone secretion" EXACT [] +is_a: GO:0032277 ! negative regulation of gonadotropin secretion +is_a: GO:0046880 ! regulation of follicle-stimulating hormone secretion +relationship: negatively_regulates GO:0046884 ! follicle-stimulating hormone secretion + +[Term] +id: GO:0046883 +name: regulation of hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0010817 ! regulation of hormone levels +is_a: GO:0023051 ! regulation of signaling +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046884 +name: follicle-stimulating hormone secretion +namespace: biological_process +def: "The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] +synonym: "follicle stimulating hormone secretion" EXACT [] +synonym: "follitropin secretion" EXACT [] +synonym: "FSH secretion" EXACT [] +is_a: GO:0032274 ! gonadotropin secretion + +[Term] +id: GO:0046885 +name: regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "regulation of hormone anabolism" EXACT [] +synonym: "regulation of hormone biosynthesis" EXACT [] +synonym: "regulation of hormone formation" EXACT [] +synonym: "regulation of hormone synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0046886 +name: positive regulation of hormone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] +synonym: "activation of hormone biosynthetic process" NARROW [] +synonym: "positive regulation of hormone anabolism" EXACT [] +synonym: "positive regulation of hormone biosynthesis" EXACT [] +synonym: "positive regulation of hormone formation" EXACT [] +synonym: "positive regulation of hormone synthesis" EXACT [] +synonym: "stimulation of hormone biosynthetic process" NARROW [] +synonym: "up regulation of hormone biosynthetic process" EXACT [] +synonym: "up-regulation of hormone biosynthetic process" EXACT [] +synonym: "upregulation of hormone biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +relationship: positively_regulates GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0046887 +name: positive regulation of hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] +synonym: "activation of hormone secretion" NARROW [] +synonym: "stimulation of hormone secretion" NARROW [] +synonym: "up regulation of hormone secretion" EXACT [] +synonym: "up-regulation of hormone secretion" EXACT [] +synonym: "upregulation of hormone secretion" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046888 +name: negative regulation of hormone secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell." [GOC:ai] +synonym: "down regulation of hormone secretion" EXACT [] +synonym: "down-regulation of hormone secretion" EXACT [] +synonym: "downregulation of hormone secretion" EXACT [] +synonym: "inhibition of hormone secretion" NARROW [] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0046879 ! hormone secretion + +[Term] +id: GO:0046889 +name: positive regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +synonym: "activation of lipid biosynthetic process" NARROW [] +synonym: "positive regulation of lipid anabolism" EXACT [] +synonym: "positive regulation of lipid biosynthesis" EXACT [] +synonym: "positive regulation of lipid formation" EXACT [] +synonym: "positive regulation of lipid synthesis" EXACT [] +synonym: "positive regulation of lipogenesis" EXACT [GOC:sl] +synonym: "stimulation of lipid biosynthetic process" NARROW [] +synonym: "up regulation of lipid biosynthetic process" EXACT [] +synonym: "up-regulation of lipid biosynthetic process" EXACT [] +synonym: "upregulation of lipid biosynthetic process" EXACT [] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: positively_regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0046890 +name: regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +synonym: "regulation of lipid anabolism" EXACT [] +synonym: "regulation of lipid biosynthesis" EXACT [] +synonym: "regulation of lipid formation" EXACT [] +synonym: "regulation of lipid synthesis" EXACT [] +synonym: "regulation of lipogenesis" EXACT [GOC:sl] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0046891 +name: peptidyl-cysteine S-carbamoylation +namespace: biological_process +def: "The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine." [RESID:AA0332] +xref: RESID:AA0332 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0046892 +name: peptidyl-S-carbamoyl-L-cysteine dehydration +namespace: biological_process +def: "The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." [PMID:12586941, RESID:AA0333] +synonym: "formation of peptidyl-S-cyanocysteine" EXACT [] +synonym: "formation of peptidyl-serine thiocyanate ester" EXACT [] +xref: RESID:AA0333 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018249 ! protein dehydration + +[Term] +id: GO:0046893 +name: iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation +namespace: biological_process +def: "The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase." [RESID:AA0334] +xref: RESID:AA0334 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0046894 +name: obsolete enzyme active site formation via S-amidino-L-cysteine +namespace: biological_process +def: "OBSOLETE. Active site formation via the transient amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:9148748. +is_obsolete: true +consider: GO:0015068 + +[Term] +id: GO:0046895 +name: N-terminal peptidyl-isoleucine methylation +namespace: biological_process +def: "The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." [RESID:AA0336] +xref: RESID:AA0336 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018203 ! peptidyl-isoleucine modification + +[Term] +id: GO:0046896 +name: N-terminal peptidyl-leucine methylation +namespace: biological_process +def: "The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine." [RESID:AA0337] +xref: RESID:AA0337 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018204 ! peptidyl-leucine modification + +[Term] +id: GO:0046897 +name: N-terminal peptidyl-tyrosine methylation +namespace: biological_process +def: "The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine." [RESID:AA0338] +xref: RESID:AA0338 +is_a: GO:0006480 ! N-terminal protein amino acid methylation +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0046898 +name: response to cycloheximide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:ef, ISBN:0198506732] +synonym: "response to actidione" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0046899 +name: nucleoside triphosphate adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP." [EC:2.7.4.10] +synonym: "GTP:AMP phosphotransferase" NARROW [] +synonym: "guanosine triphosphate-adenylate kinase" NARROW [] +synonym: "isozyme 3 of adenylate kinase activity" RELATED [EC:2.7.4.10] +synonym: "nucleoside triphosphate-adenosine monophosphate transphosphorylase activity" EXACT [] +synonym: "nucleoside-triphosphate-adenylate kinase activity" EXACT [] +synonym: "nucleoside-triphosphate:AMP phosphotransferase activity" RELATED [EC:2.7.4.10] +xref: EC:2.7.4.10 +xref: MetaCyc:2.7.4.10-RXN +xref: Reactome:R-HSA-1008248 "Adenylate Kinase 3 is a GTP-AMP phosphotransferase" +xref: RHEA:13749 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0046900 +name: tetrahydrofolylpolyglutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] +synonym: "tetrahydrofolyl-[Glu](n) metabolic process" EXACT [] +synonym: "tetrahydrofolyl-[Glu](n) metabolism" EXACT [] +synonym: "tetrahydrofolylpolyglutamate metabolism" EXACT [] +is_a: GO:0006760 ! folic acid-containing compound metabolic process + +[Term] +id: GO:0046901 +name: tetrahydrofolylpolyglutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues." [GOC:ai] +synonym: "folic acid-containing compound polyglutamylation" BROAD [GOC:dhl] +synonym: "tetrahydrofolate polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] +synonym: "tetrahydrofolyl-[Glu](n) biosynthesis" EXACT [] +synonym: "tetrahydrofolyl-[Glu](n) biosynthetic process" EXACT [] +synonym: "tetrahydrofolylpolyglutamate anabolism" EXACT [] +synonym: "tetrahydrofolylpolyglutamate biosynthesis" EXACT [] +synonym: "tetrahydrofolylpolyglutamate formation" EXACT [] +synonym: "tetrahydrofolylpolyglutamate synthesis" EXACT [] +synonym: "THF polyglutamylation" EXACT [GOC:bf, KEGG:ec00790] +is_a: GO:0009396 ! folic acid-containing compound biosynthetic process +is_a: GO:0046900 ! tetrahydrofolylpolyglutamate metabolic process + +[Term] +id: GO:0046902 +name: regulation of mitochondrial membrane permeability +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane." [GOC:bf] +synonym: "regulation of mitochondrial envelope permeability" RELATED [] +synonym: "regulation of transport across mitochondrial membrane" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization +is_a: GO:0090559 ! regulation of membrane permeability +relationship: part_of GO:0006839 ! mitochondrial transport + +[Term] +id: GO:0046903 +name: secretion +namespace: biological_process +def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] +subset: goslim_pir +is_a: GO:0006810 ! transport + +[Term] +id: GO:0046904 +name: calcium oxalate binding +namespace: molecular_function +def: "Binding to calcium oxalate, CaC2O4, a salt of oxalic acid. In animals, it may be excreted in urine or retained in the form of urinary calculi." [ISBN:0721662544] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0046905 +name: 15-cis-phytoene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate." [GOC:ai, PMID:12641468, RHEA:34479] +comment: Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. +synonym: "phytoene synthase activity" BROAD [] +xref: RHEA:34479 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0046906 +name: tetrapyrrole binding +namespace: molecular_function +def: "Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [GOC:curators, ISBN:0198506732] +subset: goslim_metagenomics +subset: goslim_pir +synonym: "porphyrin binding" NARROW [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0046907 +name: intracellular transport +namespace: biological_process +alt_id: GO:1902582 +def: "The directed movement of substances within a cell." [GOC:ai] +synonym: "single organism intracellular transport" RELATED [GOC:TermGenie] +synonym: "single-organism intracellular transport" RELATED [] +is_a: GO:0006810 ! transport +is_a: GO:0051641 ! cellular localization +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0046908 +name: obsolete negative regulation of crystal formation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the spontaneous (nonenzymatic) formation of crystals in a solution, for example, calcium oxalate crystals in urine." [GOC:ai] +comment: This term was made obsolete because a more appropriate term was created. +synonym: "negative regulation of crystal formation" EXACT [] +synonym: "negative regulation of mineralization" RELATED [] +is_obsolete: true +replaced_by: GO:0050801 + +[Term] +id: GO:0046909 +name: obsolete intermembrane transport +namespace: biological_process +def: "OBSOLETE. The directed movement of substances between any membrane of a cell, including the plasma membrane and its regions." [GOC:ai, GOC:pr, PMID:10671554] +comment: The reason for obsoletion is that this term was incorrectly named, defined, and placed in the ontology, and thus had been used to annotate two unrelated processes of [intermembrane lipid transfer] and processes related to [vesicular transport]. It was also inappropriately used as the parent term for [protein transport from ciliary membrane to plasma membrane], which has already been moved to an appropriate location as a child of [protein transport within lipid bilayer]. +is_obsolete: true +consider: GO:0016192 +consider: GO:0120009 + +[Term] +id: GO:0046910 +name: pectinesterase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of pectinesterase." [GOC:ai, PMID:10880981] +comment: See also the molecular function term 'pectinesterase activity ; GO:0030599'. +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0046911 +name: metal chelating activity +namespace: molecular_function +def: "The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring." [ISBN:0198506732, ISBN:0716731363] +synonym: "heavy metal chelation" NARROW [] +synonym: "metal chelation" EXACT [] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0046912 +name: acyltransferase, acyl groups converted into alkyl on transfer +namespace: molecular_function +def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] +synonym: "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer" EXACT [] +xref: EC:2.3.3.- +is_a: GO:0016746 ! acyltransferase activity + +[Term] +id: GO:0046914 +name: transition metal ion binding +namespace: molecular_function +def: "Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] +is_a: GO:0046872 ! metal ion binding + +[Term] +id: GO:0046915 +name: transition metal ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0046916 +name: cellular transition metal ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:mah, ISBN:0198506732] +is_a: GO:0006875 ! cellular metal ion homeostasis +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0046917 +name: triphosphoribosyl-dephospho-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine." [EC:2.4.2.52] +synonym: "2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity" RELATED [EC:2.4.2.52] +synonym: "ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity" EXACT [] +synonym: "ATP:dephospho-CoA 5-triphosphoribosyl transferase activity" EXACT [] +synonym: "CitG activity" RELATED [] +xref: EC:2.4.2.52 +xref: MetaCyc:2.7.8.25-RXN +xref: RHEA:15117 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0046918 +name: N-terminal peptidyl-glycine N-palmitoylation +namespace: biological_process +def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine." [RESID:AA0339] +comment: Palmitoylation of glycine only occurs when glycine is at the N-terminal position of a protein. +xref: RESID:AA0339 +is_a: GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0046919 +name: pyruvyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0046920 +name: alpha-(1->3)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage." [GOC:ai] +synonym: "alpha(1,3)-fucosyltransferase activity" EXACT [] +synonym: "alpha-(1,3)-fucosyltransferase activity" EXACT [] +synonym: "alpha-1,3-fucosyltransferase activity" EXACT [] +xref: Reactome:R-HSA-9603984 "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX" +xref: Reactome:R-HSA-9605609 "FUT3 transfers Fuc to Type 1 MSGG to form sLeA" +xref: Reactome:R-HSA-9605644 "FUT3 transfers Fuc to Type 1 DSGG to form dsLeA" +xref: Reactome:R-HSA-9605682 "FUT3,5,6,7 transfers Fuc to Type 2 MSGG to form sLeX" +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0046921 +name: alpha-(1->6)-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage." [GOC:ai] +synonym: "alpha(1,6)-fucosyltransferase activity" EXACT [] +synonym: "alpha-(1,6)-fucosyltransferase activity" EXACT [] +synonym: "alpha-1,6-fucosyltransferase activity" EXACT [] +is_a: GO:0008417 ! fucosyltransferase activity + +[Term] +id: GO:0046922 +name: peptide-O-fucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor." [EC:2.4.1.221] +synonym: "GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity" RELATED [EC:2.4.1.221] +synonym: "GDP-fucose protein O-fucosyltransferase activity" RELATED [EC:2.4.1.221] +synonym: "GDP-fucose:polypeptide fucosyltransferase activity" RELATED [EC:2.4.1.221] +synonym: "GDP-L-fucose:polypeptide fucosyltransferase activity" RELATED [EC:2.4.1.221] +xref: EC:2.4.1.221 +xref: MetaCyc:2.4.1.221-RXN +xref: Reactome:R-HSA-1912349 "Fucosylation of Pre-NOTCH by POFUT1" +xref: Reactome:R-HSA-5173192 "POFUT2 transfers fucose to TSR domain-containing proteins" +is_a: GO:0008417 ! fucosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0046923 +name: ER retention sequence binding +namespace: molecular_function +def: "Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER." [GOC:ai] +synonym: "endoplasmic reticulum retention sequence binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:0046924 +name: peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine +namespace: biological_process +def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine." [PMID:12696888, RESID:AA0340] +xref: RESID:AA0340 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0046925 +name: peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine +namespace: biological_process +def: "The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine." [PMID:12696888, RESID:AA0341] +xref: RESID:AA0341 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018207 ! peptidyl-phenylalanine modification + +[Term] +id: GO:0046926 +name: peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine +namespace: biological_process +def: "The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888, RESID:AA0342] +xref: RESID:AA0342 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046927 +name: peptidyl-threonine racemization +namespace: biological_process +def: "The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine." [PMID:12696888] +is_a: GO:0018085 ! peptidyl-L-amino acid racemization +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0046928 +name: regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell." [GOC:ai] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0051588 ! regulation of neurotransmitter transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0046929 +name: negative regulation of neurotransmitter secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:ai] +synonym: "conotoxin activity" NARROW [] +synonym: "down regulation of neurotransmitter secretion" EXACT [] +synonym: "down-regulation of neurotransmitter secretion" EXACT [] +synonym: "downregulation of neurotransmitter secretion" EXACT [] +synonym: "inhibition of neurotransmitter secretion" NARROW [] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0051589 ! negative regulation of neurotransmitter transport +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0046930 +name: pore complex +namespace: cellular_component +def: "A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] +synonym: "channel-forming toxin activity" RELATED [] +synonym: "pore" EXACT [] +synonym: "pore-forming toxin activity" RELATED [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0016021 ! integral component of membrane + +[Term] +id: GO:0046931 +name: pore complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases." [GOC:jl, GOC:mah] +comment: See also the cellular component term 'pore complex ; GO:0046930'. +synonym: "pore biosynthesis" EXACT [] +synonym: "pore complex biogenesis" RELATED [GOC:mah] +synonym: "pore formation" EXACT [] +synonym: "pore-forming toxin activity" RELATED [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0046932 +name: sodium-transporting ATP synthase activity, rotational mechanism +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism." [RHEA:58158] +synonym: "sodium-translocating F-type ATPase activity" EXACT [] +synonym: "sodium-transporting two-sector ATPase activity" EXACT [] +xref: EC:7.2.2.1 +xref: MetaCyc:3.6.3.15-RXN +xref: RHEA:58156 +xref: RHEA:58158 +xref: TC:3.A.2.1.2 +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0046933 +name: proton-transporting ATP synthase activity, rotational mechanism +namespace: molecular_function +def: "Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out)." [RHEA:57720] +synonym: "H+-transporting ATP synthase activity" RELATED [EC:7.1.2.2] +synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] +synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [] +synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] +xref: EC:7.1.2.2 +xref: MetaCyc:ATPSYN-RXN +xref: Reactome:R-HSA-164832 "ATPase synthesizes ATP" +xref: RHEA:57720 +xref: TC:3.A.2.1.1 +is_a: GO:0015252 ! proton channel activity +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0046934 +name: phosphatidylinositol-4,5-bisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21292] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity" RELATED [EC:2.7.1.153] +synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] +synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] +synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] +synonym: "type I phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.153] +xref: EC:2.7.1.153 +xref: KEGG_REACTION:R04545 +xref: MetaCyc:2.7.1.153-RXN +xref: Reactome:R-HSA-1226014 "Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants" +xref: Reactome:R-HSA-1250370 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers" +xref: Reactome:R-HSA-1250462 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3" +xref: Reactome:R-HSA-1306957 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR" +xref: Reactome:R-HSA-1306979 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1" +xref: Reactome:R-HSA-1676048 "PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane" +xref: Reactome:R-HSA-177939 "PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)" +xref: Reactome:R-HSA-1839091 "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-1839107 "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3." +xref: Reactome:R-HSA-186800 "PI3K catalyses the phosphorylation of PIP2 to PIP3" +xref: Reactome:R-HSA-198266 "PI3K produces PIP3 and other phosphatidyl inositides" +xref: Reactome:R-HSA-202365 "PI3K bound to TRAT1 phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-2029271 "PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-2076220 "CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3" +xref: Reactome:R-HSA-2316434 "PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-2394007 "PI3K gain of function mutants phosphorylate PIP2 to PIP3" +xref: Reactome:R-HSA-2424480 "PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-2730870 "Phosphorylation of PIP2 to PIP3 by PI3K" +xref: Reactome:R-HSA-389158 "CD28 bound PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-392300 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3" +xref: Reactome:R-HSA-437162 "PI3K alpha, beta, gamma convert PIP2 to PIP3" +xref: Reactome:R-HSA-5218819 "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5637801 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII" +xref: Reactome:R-HSA-5654690 "FGFR1-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654692 "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654697 "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654701 "FGFR2-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654705 "FGFR3-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654709 "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654714 "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5654717 "FGFR4-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5655235 "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5655289 "Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5655290 "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-5655323 "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-8852019 "MET bound PI3K generates PIP3" +xref: Reactome:R-HSA-8853323 "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-9021627 "EPOR-associated PI3K phosphorylates PIP2 to PIP3" +xref: Reactome:R-HSA-9603445 "Activated NTRK3 stimulates PI3K activity" +xref: Reactome:R-HSA-9664664 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3" +xref: Reactome:R-HSA-9664940 "PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3" +xref: Reactome:R-HSA-9665407 "PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3" +xref: Reactome:R-HSA-9672162 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers" +xref: Reactome:R-HSA-9672177 "PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR" +xref: RHEA:21292 +is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity +is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity + +[Term] +id: GO:0046935 +name: 1-phosphatidylinositol-3-kinase regulator activity +namespace: molecular_function +def: "Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity." [GOC:ai] +comment: See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. +synonym: "1-phosphatidylinositol 3-kinase regulator activity" EXACT [] +synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" NARROW [] +is_a: GO:0035014 ! phosphatidylinositol 3-kinase regulator activity + +[Term] +id: GO:0046936 +name: 2'-deoxyadenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3." [GOC:ai, RHEA:28190] +synonym: "deoxyadenosine deaminase reaction" EXACT [] +xref: MetaCyc:ADDALT-RXN +xref: RHEA:28190 +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0046937 +name: phytochelatin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732] +synonym: "cadystin metabolic process" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "cadystin metabolism" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "phytochelatin metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0046938 +name: phytochelatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11." [ISBN:0198506732] +synonym: "cadystin biosynthetic process" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "phytochelatin anabolism" EXACT [] +synonym: "phytochelatin biosynthesis" EXACT [] +synonym: "phytochelatin formation" EXACT [] +synonym: "phytochelatin synthesis" EXACT [] +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046937 ! phytochelatin metabolic process + +[Term] +id: GO:0046939 +name: nucleotide phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] +is_a: GO:0016310 ! phosphorylation + +[Term] +id: GO:0046940 +name: nucleoside monophosphate phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside." [GOC:ai] +is_a: GO:0009123 ! nucleoside monophosphate metabolic process +is_a: GO:0009165 ! nucleotide biosynthetic process + +[Term] +id: GO:0046941 +name: azetidine-2-carboxylic acid acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0046942 +name: carboxylic acid transport +namespace: biological_process +def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] +is_a: GO:0015711 ! organic anion transport + +[Term] +id: GO:0046943 +name: carboxylic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] +xref: Reactome:R-HSA-390347 "Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane" +is_a: GO:0005342 ! organic acid transmembrane transporter activity + +[Term] +id: GO:0046944 +name: protein carbamoylation +namespace: biological_process +def: "The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2." [GOC:ai] +synonym: "protein amino acid carbamoylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0046945 +name: N-terminal peptidyl-alanine N-carbamoylation +namespace: biological_process +def: "The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine." [RESID:AA0343] +synonym: "N-terminal peptidyl-alanine N-carbamylation" RELATED [] +xref: RESID:AA0343 +is_a: GO:0018194 ! peptidyl-alanine modification +is_a: GO:0046944 ! protein carbamoylation +is_a: GO:0050990 ! N-terminal protein amino acid carbamoylation + +[Term] +id: GO:0046946 +name: hydroxylysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases." [ISBN:0198506732, PubChem_Compound:1029] +synonym: "hydroxylysine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0009066 ! aspartate family amino acid metabolic process + +[Term] +id: GO:0046947 +name: hydroxylysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732] +synonym: "hydroxylysine anabolism" EXACT [] +synonym: "hydroxylysine biosynthesis" EXACT [] +synonym: "hydroxylysine formation" EXACT [] +synonym: "hydroxylysine synthesis" EXACT [] +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0046946 ! hydroxylysine metabolic process + +[Term] +id: GO:0046948 +name: hydroxylysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid." [ISBN:0198506732] +synonym: "hydroxylysine breakdown" EXACT [] +synonym: "hydroxylysine catabolism" EXACT [] +synonym: "hydroxylysine degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0009068 ! aspartate family amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046946 ! hydroxylysine metabolic process + +[Term] +id: GO:0046949 +name: fatty-acyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [ISBN:0198506732] +synonym: "fatty acyl CoA biosynthetic process" EXACT [] +synonym: "fatty-acyl-CoA anabolism" EXACT [] +synonym: "fatty-acyl-CoA biosynthesis" EXACT [] +synonym: "fatty-acyl-CoA formation" EXACT [] +synonym: "fatty-acyl-CoA synthesis" EXACT [] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process + +[Term] +id: GO:0046950 +name: cellular ketone body metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism." [ISBN:0198506732] +subset: goslim_pir +synonym: "cellular ketone body metabolism" EXACT [] +is_a: GO:0044237 ! cellular metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0046951 +name: ketone body biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA." [ISBN:0198506732] +synonym: "ketone body anabolism" EXACT [] +synonym: "ketone body biosynthesis" EXACT [] +synonym: "ketone body formation" EXACT [] +synonym: "ketone body synthesis" EXACT [] +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:0044283 ! small molecule biosynthetic process +is_a: GO:0046950 ! cellular ketone body metabolic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process +is_a: GO:1902224 ! ketone body metabolic process + +[Term] +id: GO:0046952 +name: ketone body catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA." [ISBN:0198506732] +synonym: "ketolysis" EXACT [MetaCyc:PWY66-368] +synonym: "ketone body breakdown" EXACT [] +synonym: "ketone body catabolism" EXACT [Reactome:R-HSA-77108] +synonym: "ketone body degradation" EXACT [] +synonym: "utilization of ketone bodies" EXACT [Reactome:R-HSA-77108] +xref: MetaCyc:PWY66-368 +xref: Reactome:R-HSA-77108 +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044282 ! small molecule catabolic process +is_a: GO:0046950 ! cellular ketone body metabolic process +is_a: GO:1901569 ! fatty acid derivative catabolic process +is_a: GO:1902224 ! ketone body metabolic process + +[Term] +id: GO:0046956 +name: positive phototaxis +namespace: biological_process +alt_id: GO:0046954 +def: "The directed movement of a cell or organism towards a source of light." [GOC:ai] +synonym: "positive phototactic behavior" EXACT [] +synonym: "positive phototactic behaviour" EXACT [] +synonym: "positive taxis in response to light" EXACT [] +is_a: GO:0042331 ! phototaxis +is_a: GO:0052128 ! positive energy taxis + +[Term] +id: GO:0046957 +name: negative phototaxis +namespace: biological_process +alt_id: GO:0046955 +def: "The directed movement of a cell or organism away from a source of light." [GOC:ai] +synonym: "negative phototactic behavior" EXACT [] +synonym: "negative phototactic behaviour" EXACT [] +synonym: "negative taxis in response to light" EXACT [] +is_a: GO:0042331 ! phototaxis +is_a: GO:0052129 ! negative energy taxis + +[Term] +id: GO:0046958 +name: nonassociative learning +namespace: biological_process +def: "A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment." [ISBN:0582227089] +synonym: "unconditional response" EXACT [] +is_a: GO:0007612 ! learning + +[Term] +id: GO:0046959 +name: habituation +namespace: biological_process +def: "A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented." [ISBN:0582227089] +xref: Wikipedia:Habituation +is_a: GO:0046958 ! nonassociative learning + +[Term] +id: GO:0046960 +name: sensitization +namespace: biological_process +def: "An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched." [ISBN:0582227089] +xref: Wikipedia:Sensitization +is_a: GO:0046958 ! nonassociative learning + +[Term] +id: GO:0046961 +name: proton-transporting ATPase activity, rotational mechanism +namespace: molecular_function +def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [RHEA:57721] +synonym: "ATP phosphohydrolase (H+-transporting) activity" NARROW [] +synonym: "ATP synthase activity" NARROW [EC:7.1.2.2] +synonym: "chloroplast ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(0)F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F(o)F(1)-ATPase activity" NARROW [EC:7.1.2.2] +synonym: "F0F1-ATPase" NARROW [EC:7.1.2.2] +synonym: "F1-ATPase" NARROW [] +synonym: "FoF1-ATPase" NARROW [EC:7.1.2.2] +synonym: "H(+)-transporting ATP synthase activity" NARROW [EC:7.1.2.2] +synonym: "H+-transporting ATPase activity" NARROW [EC:7.1.2.2] +synonym: "hydrogen ion translocating A-type ATPase activity" NARROW [] +synonym: "hydrogen ion translocating F-type ATPase activity" NARROW [] +synonym: "hydrogen ion translocating V-type ATPase activity" NARROW [] +synonym: "hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [] +synonym: "hydrogen ion transporting two-sector ATPase activity" NARROW [] +synonym: "mitochondrial ATPase activity" NARROW [EC:7.1.2.2] +xref: RHEA:57721 +is_a: GO:0009678 ! pyrophosphate hydrolysis-driven proton transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism + +[Term] +id: GO:0046962 +name: sodium-transporting ATPase activity, rotational mechanism +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism." [PMID:30791207, RHEA:58157] +comment: Found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis; similar to EC:7.1.2.2 but pumps Na(+) rather than H(+). (Source: EC:7.2.2.1) +synonym: "ATP phosphohydrolase (Na+-transporting) activity" RELATED [] +synonym: "ATP synthase, sodium ion specific activity" RELATED [EC:7.2.2.1] +synonym: "Na(+)-translocating ATPase activity" BROAD [] +synonym: "Na(+)-transporting two-sector ATPase activity" RELATED [EC:7.2.2.1] +synonym: "Na+-translocating ATPase activity" RELATED [EC:7.2.2.1] +synonym: "Na+-translocating F1Fo-ATPase" NARROW [] +synonym: "Na+-transporting two-sector ATPase" NARROW [EC:7.2.2.1] +synonym: "sodium transporting ATPase activity, rotational mechanism" EXACT [] +synonym: "sodium-translocating F-type ATPase activity" NARROW [] +synonym: "sodium-translocating V-type ATPase activity" NARROW [] +synonym: "sodium-transporting two-sector ATPase activity" NARROW [] +synonym: "vacuolar-type Na+-ATPase" NARROW [] +synonym: "vacuolar-type Na+-translocating ATPase" NARROW [] +xref: EC:7.2.2.1 +xref: MetaCyc:3.6.3.15-RXN +xref: RHEA:58156 +xref: RHEA:58157 +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism + +[Term] +id: GO:0046963 +name: 3'-phosphoadenosine 5'-phosphosulfate transport +namespace: biological_process +def: "The directed movement of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] +synonym: "3'-phosphoadenosine 5'-phosphosulphate transport" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate transport" EXACT [] +synonym: "PAPS transport" EXACT [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:0046964 +name: 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other." [ISBN:0198506732] +synonym: "3'-phosphoadenosine 5'-phosphosulphate transporter activity" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity" EXACT [] +synonym: "PAPS transporter activity" EXACT [] +xref: Reactome:R-HSA-741449 "SLC35B2,3 transport cytosolic PAPS to Golgi lumen" +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0046965 +name: retinoid X receptor binding +namespace: molecular_function +def: "Binding to a retinoid X receptor." [GOC:ai] +synonym: "RXR binding" EXACT [] +is_a: GO:0042974 ! retinoic acid receptor binding + +[Term] +id: GO:0046966 +name: thyroid hormone receptor binding +namespace: molecular_function +def: "Binding to a thyroid hormone receptor." [GOC:ai] +synonym: "ligand-dependent thyroid hormone receptor interactor activity" NARROW [] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0046967 +name: cytosol to endoplasmic reticulum transport +namespace: biological_process +def: "The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell." [GOC:ai] +synonym: "cytosol to ER transport" EXACT [] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0046968 +name: peptide antigen transport +namespace: biological_process +def: "The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591] +is_a: GO:0015833 ! peptide transport +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0046969 +name: NAD-dependent histone deacetylase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [PMID:28450737] +xref: Reactome:R-HSA-9604829 "SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters" +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity +is_a: GO:0032129 ! histone deacetylase activity (H3-K9 specific) + +[Term] +id: GO:0046970 +name: NAD-dependent histone deacetylase activity (H4-K16 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein." [GOC:vw, PMID:28450737] +is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific) +is_a: GO:0046969 ! NAD-dependent histone deacetylase activity (H3-K9 specific) + +[Term] +id: GO:0046972 +name: histone acetyltransferase activity (H4-K16 specific) +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4." [EC:2.3.1.48] +synonym: "histone lysine acetyltransferase activity (H4-K16 specific)" EXACT [] +is_a: GO:0010485 ! H4 histone acetyltransferase activity + +[Term] +id: GO:0046973 +name: obsolete histone lysine N-methyltransferase activity (H3-K24 specific) +namespace: molecular_function +def: "OBSOLETE. Catalysis of the addition of a methyl group onto lysine at position 24 of the histone H3 protein." [GOC:ai] +comment: This term was made obsolete because there is no lysine at position 24 of histone H3. +synonym: "histone lysine N-methyltransferase activity (H3-K24 specific)" EXACT [] +is_obsolete: true +consider: GO:0042800 + +[Term] +id: GO:0046974 +name: histone methyltransferase activity (H3-K9 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein." [GOC:ai] +synonym: "histone lysine N-methyltransferase activity (H3-K9 specific)" EXACT [] +synonym: "histone methylase activity (H3-K9 specific)" EXACT [GOC:mah] +xref: Reactome:R-HSA-427336 "TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9." +xref: Reactome:R-HSA-427527 "eNoSC dimethylates histone H3 at lysine-9" +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046975 +name: histone methyltransferase activity (H3-K36 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein." [GOC:ai] +synonym: "histone lysine N-methyltransferase activity (H3-K36 specific)" EXACT [] +synonym: "histone methylase activity (H3-K36 specific)" EXACT [GOC:mah] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046976 +name: histone methyltransferase activity (H3-K27 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein." [GOC:ai] +synonym: "histone lysine N-methyltransferase activity (H3-K27 specific)" EXACT [] +synonym: "histone methylase activity (H3-K27 specific)" EXACT [GOC:mah] +xref: Reactome:R-HSA-3240295 "PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter" +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0046977 +name: TAP binding +namespace: molecular_function +def: "Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2." [PMID:11133832] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046978 +name: TAP1 binding +namespace: molecular_function +def: "Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] +is_a: GO:0046977 ! TAP binding + +[Term] +id: GO:0046979 +name: TAP2 binding +namespace: molecular_function +def: "Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein." [PMID:11133832] +is_a: GO:0046977 ! TAP binding + +[Term] +id: GO:0046980 +name: tapasin binding +namespace: molecular_function +def: "Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules." [PMID:12594855] +synonym: "TAP binding protein binding" EXACT [HGNC:11566] +synonym: "TAPBP binding" RELATED [HGNC:11566] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046981 +name: beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids." [GOC:bf, PMID:12130631, PMID:12130651] +synonym: "UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [] +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0046982 +name: protein heterodimerization activity +namespace: molecular_function +def: "Binding to a nonidentical protein to form a heterodimer." [GOC:ai] +subset: goslim_chembl +is_a: GO:0046983 ! protein dimerization activity + +[Term] +id: GO:0046983 +name: protein dimerization activity +namespace: molecular_function +def: "The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits." [ISBN:0198506732] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0046984 +name: regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "regulation of haemoglobin biosynthesis" EXACT [] +synonym: "regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "regulation of hemoglobin anabolism" EXACT [] +synonym: "regulation of hemoglobin biosynthesis" EXACT [] +synonym: "regulation of hemoglobin formation" EXACT [] +synonym: "regulation of hemoglobin synthesis" EXACT [] +is_a: GO:0051246 ! regulation of protein metabolic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046985 +name: positive regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "activation of hemoglobin biosynthetic process" NARROW [] +synonym: "positive regulation of haemoglobin biosynthesis" EXACT [] +synonym: "positive regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "positive regulation of hemoglobin anabolism" EXACT [] +synonym: "positive regulation of hemoglobin biosynthesis" EXACT [] +synonym: "positive regulation of hemoglobin formation" EXACT [] +synonym: "positive regulation of hemoglobin synthesis" EXACT [] +synonym: "stimulation of hemoglobin biosynthetic process" NARROW [] +synonym: "up regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "up-regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "upregulation of hemoglobin biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046986 +name: negative regulation of hemoglobin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [GOC:ai] +synonym: "down regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "down-regulation of hemoglobin biosynthetic process" EXACT [] +synonym: "downregulation of hemoglobin biosynthetic process" EXACT [] +synonym: "inhibition of hemoglobin biosynthetic process" NARROW [] +synonym: "negative regulation of haemoglobin biosynthesis" EXACT [] +synonym: "negative regulation of haemoglobin biosynthetic process" EXACT [] +synonym: "negative regulation of hemoglobin anabolism" EXACT [] +synonym: "negative regulation of hemoglobin biosynthesis" EXACT [] +synonym: "negative regulation of hemoglobin formation" EXACT [] +synonym: "negative regulation of hemoglobin synthesis" EXACT [] +is_a: GO:0046984 ! regulation of hemoglobin biosynthetic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0042541 ! hemoglobin biosynthetic process + +[Term] +id: GO:0046987 +name: N-acetyllactosamine beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine)." [GOC:bf, PMID:12511570] +synonym: "galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity" EXACT [] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046988 +name: asioloorosomucoid beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid." [GOC:bf, PMID:12511570] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046989 +name: galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids." [GOC:bf, PMID:12511570] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0046990 +name: N-hydroxyarylamine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine." [EC:2.3.1.118, MetaCyc:2.3.1.118-RXN] +synonym: "acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity" RELATED [EC:2.3.1.118] +synonym: "arylhydroxamate N,O-acetyltransferase activity" RELATED [EC:2.3.1.118] +synonym: "N-hydroxy-2-aminofluorene-O-acetyltransferase activity" RELATED [EC:2.3.1.118] +xref: EC:2.3.1.118 +xref: MetaCyc:2.3.1.118-RXN +xref: RHEA:20277 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0046992 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y." [GOC:ai] +synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" NARROW [] +xref: EC:1.21.-.- +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0046993 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen." [GOC:ai] +xref: EC:1.21.3.- +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0046994 +name: oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound." [GOC:jl] +xref: EC:1.12.5.- +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0046995 +name: oxidoreductase activity, acting on hydrogen as donor, with other known acceptors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound." [GOC:ai] +xref: EC:1.12.98.- +is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor + +[Term] +id: GO:0046996 +name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and the latter donor is dehydrogenated." [GOC:mah] +comment: This term was obsoleted because it represented an unnecessary grouping class. +synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NADH or NADPH as one donor, and the other dehydrogenated" RELATED [] +xref: EC:1.14.21.- +is_obsolete: true + +[Term] +id: GO:0046997 +name: oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] +xref: EC:1.5.8.- +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0046998 +name: (S)-usnate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH." [EC:1.1.1.199, RHEA:21876] +synonym: "L-usnic acid dehydrogenase activity" RELATED [EC:1.1.1.199] +synonym: "reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)" RELATED [EC:1.1.1.199] +xref: EC:1.1.1.199 +xref: KEGG_REACTION:R07345 +xref: MetaCyc:1.1.1.199-RXN +xref: RHEA:21876 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0046999 +name: regulation of conjugation +namespace: biological_process +def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0000746 ! conjugation + +[Term] +id: GO:0047000 +name: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH." [EC:1.1.1.126, RHEA:15109] +synonym: "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.126] +synonym: "2-keto-3-deoxy-D-gluconate dehydrogenase activity" RELATED [EC:1.1.1.126] +xref: EC:1.1.1.126 +xref: KEGG_REACTION:R01543 +xref: MetaCyc:1.1.1.126-RXN +xref: RHEA:15109 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047001 +name: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate." [EC:1.1.1.127, MetaCyc:1.1.1.127-RXN] +synonym: "2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity" RELATED [EC:1.1.1.127] +synonym: "2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity" RELATED [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" RELATED [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate 5-dehydrogenase activity" RELATED [EC:1.1.1.127] +synonym: "2-keto-3-deoxygluconate dehydrogenase activity" RELATED [EC:1.1.1.127] +xref: EC:1.1.1.127 +xref: MetaCyc:1.1.1.127-RXN +xref: RHEA:24232 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047002 +name: L-arabinitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH." [EC:1.1.1.13, RHEA:21356] +synonym: "L-arabinitol 2-dehydrogenase (ribulose forming) activity" EXACT [] +xref: EC:1.1.1.13 +xref: KEGG_REACTION:R02441 +xref: MetaCyc:1.1.1.13-RXN +xref: RHEA:21356 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047003 +name: dTDP-6-deoxy-L-talose 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.134, RHEA:23648] +synonym: "dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)" RELATED [EC:1.1.1.134] +synonym: "dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.134] +synonym: "TDP-6-deoxy-L-talose dehydrogenase activity" RELATED [EC:1.1.1.134] +synonym: "thymidine diphospho-6-deoxy-L-talose dehydrogenase activity" RELATED [EC:1.1.1.134] +xref: EC:1.1.1.134 +xref: KEGG_REACTION:R02776 +xref: MetaCyc:1.1.1.134-RXN +xref: RHEA:23648 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047004 +name: UDP-N-acetylglucosamine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate." [EC:1.1.1.136, RHEA:13325] +synonym: "UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity" RELATED [EC:1.1.1.136] +synonym: "UDP-GLcNAc dehydrogenase activity" RELATED [EC:1.1.1.136] +synonym: "UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.136] +synonym: "UDPacetylglucosamine dehydrogenase activity" RELATED [EC:1.1.1.136] +synonym: "uridine diphosphoacetylglucosamine dehydrogenase activity" RELATED [EC:1.1.1.136] +xref: EC:1.1.1.136 +xref: KEGG_REACTION:R00421 +xref: MetaCyc:1.1.1.136-RXN +xref: RHEA:13325 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047005 +name: 16-alpha-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid." [EC:1.1.1.147, MetaCyc:1.1.1.147-RXN] +synonym: "16alpha-hydroxy steroid dehydrogenase activity" RELATED [EC:1.1.1.147] +synonym: "16alpha-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.147] +synonym: "16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity" RELATED [EC:1.1.1.147] +xref: EC:1.1.1.147 +xref: MetaCyc:1.1.1.147-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047006 +name: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone." [EC:1.1.1.149, MetaCyc:1.1.1.149-RXN] +synonym: "20alpha-HSD" RELATED [EC:1.1.1.149] +synonym: "20alpha-HSDH" RELATED [EC:1.1.1.149] +synonym: "20alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.149] +synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.149] +synonym: "20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity" BROAD [EC:1.1.1.149] +xref: EC:1.1.1.149 +xref: MetaCyc:1.1.1.149-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047007 +name: pregnan-21-ol dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al." [EC:1.1.1.150, RHEA:11448] +synonym: "21-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.50] +synonym: "21-hydroxysteroid:NAD+ 21-oxidoreductase activity" BROAD [EC:1.1.1.150] +xref: EC:1.1.1.150 +xref: KEGG_REACTION:R03043 +xref: MetaCyc:1.1.1.150-RXN +xref: RHEA:11448 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047008 +name: pregnan-21-ol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al." [EC:1.1.1.151, RHEA:23712] +synonym: "21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.151] +synonym: "21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity" BROAD [EC:1.1.1.151] +synonym: "21-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.151] +synonym: "21-hydroxysteroid dehydrogenase (NADP+) activity" BROAD [EC:1.1.1.151] +synonym: "21-hydroxysteroid:NADP+ 21-oxidoreductase activity" BROAD [EC:1.1.1.151] +synonym: "NADP-21-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.151] +xref: EC:1.1.1.151 +xref: KEGG_REACTION:R03044 +xref: MetaCyc:1.1.1.151-RXN +xref: RHEA:23712 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047009 +name: 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione." [EC:1.1.1.152, MetaCyc:1.1.1.152-RXN] +synonym: "3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity" RELATED [EC:1.1.1.152] +synonym: "3alpha-hydroxy-5beta-steroid dehydrogenase activity" RELATED [EC:1.1.1.152] +synonym: "3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.152] +synonym: "etiocholanolone 3-alpha-dehydrogenase activity" RELATED [EC:1.1.1.152] +synonym: "etiocholanolone 3alpha-dehydrogenase activity" RELATED [EC:1.1.1.152] +xref: EC:1.1.1.152 +xref: MetaCyc:1.1.1.152-RXN +xref: RHEA:10356 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047010 +name: hydroxycyclohexanecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH." [EC:1.1.1.166, RHEA:10516] +synonym: "(-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity" RELATED [EC:1.1.1.166] +synonym: "(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.166] +synonym: "dihydroxycyclohexanecarboxylate dehydrogenase activity" RELATED [EC:1.1.1.166] +xref: EC:1.1.1.166 +xref: KEGG_REACTION:R05315 +xref: MetaCyc:1.1.1.166-RXN +xref: RHEA:10516 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047011 +name: 2-dehydropantolactone reductase (A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.168, MetaCyc:1.1.1.168-RXN] +synonym: "(R)-pantolactone:NADP+ oxidoreductase (A-specific)" RELATED [EC:1.1.1.168] +synonym: "2-dehydropantoyl-lactone reductase (A-specific) activity" RELATED [EC:1.1.1.168] +synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] +synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.168] +synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.168] +xref: EC:1.1.1.168 +xref: MetaCyc:1.1.1.168-RXN +is_a: GO:0036441 ! 2-dehydropantolactone reductase activity + +[Term] +id: GO:0047012 +name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one." [EC:1.1.1.170, MetaCyc:1.1.1.170-RXN] +synonym: "3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" EXACT [] +synonym: "3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [EC:1.1.1.170] +synonym: "3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity" RELATED [EC:1.1.1.170] +synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] +synonym: "sterol 4-alpha-carboxylic decarboxylase activity" RELATED [EC:1.1.1.170] +xref: EC:1.1.1.170 +xref: MetaCyc:1.1.1.170-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047013 +name: cholate 12-alpha dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.176, RHEA:14129] +synonym: "12-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] +synonym: "12alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.176] +synonym: "12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] +synonym: "12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.176] +synonym: "NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] +synonym: "NADP-12alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.176] +xref: EC:1.1.1.176 +xref: KEGG_REACTION:R02793 +xref: MetaCyc:1.1.1.176-RXN +xref: RHEA:14129 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047014 +name: glycerol-3-phosphate 1-dehydrogenase [NADP+] activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH." [EC:1.1.1.177, RHEA:19773] +synonym: "glycerin-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.177] +synonym: "glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.177] +synonym: "L-glycerol 3-phosphate:NADP oxidoreductase activity" RELATED [EC:1.1.1.177] +synonym: "NADPH-dependent glycerin-3-phosphate dehydrogenase activity" RELATED [EC:1.1.1.177] +synonym: "sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.177] +xref: EC:1.1.1.177 +xref: KEGG_REACTION:R00845 +xref: MetaCyc:1.1.1.177-RXN +xref: RHEA:19773 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047015 +name: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA." [EC:1.1.1.178, MetaCyc:1.1.1.178-RXN] +synonym: "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity" RELATED [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity" RELATED [EC:1.1.1.178] +synonym: "2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity" RELATED [EC:1.1.1.178] +xref: EC:1.1.1.178 +xref: MetaCyc:1.1.1.178-RXN +xref: RHEA:13281 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047016 +name: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one." [EC:1.1.1.181, MetaCyc:1.1.1.181-RXN] +synonym: "3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity" RELATED [EC:1.1.1.181] +synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.181] +synonym: "cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity" RELATED [EC:1.1.1.181] +synonym: "cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.181] +xref: EC:1.1.1.181 +xref: MetaCyc:1.1.1.181-RXN +xref: RHEA:11896 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047017 +name: prostaglandin-F synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:1.1.1.188, MetaCyc:1.1.1.188-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity" RELATED [EC:1.1.1.188] +synonym: "NADPH-dependent prostaglandin D2 11-keto reductase activity" RELATED [EC:1.1.1.188] +synonym: "PGD(2) 11-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "PGD2 11-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "PGF synthetase activity" RELATED [EC:1.1.1.188] +synonym: "PGF2alpha synthetase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin 11-keto reductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin 11-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin D2-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin F synthase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin F synthetase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D(2) 11-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D(2) 11-reductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D(2) ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D2 11-ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D2 11-reductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-D2 ketoreductase activity" RELATED [EC:1.1.1.188] +synonym: "prostaglandin-F synthetase activity" RELATED [EC:1.1.1.188] +synonym: "reductase, 15-hydroxy-11-oxoprostaglandin" RELATED [EC:1.1.1.188] +synonym: "synthetase, prostaglandin F2alpha" RELATED [EC:1.1.1.188] +xref: EC:1.1.1.188 +xref: MetaCyc:1.1.1.188-RXN +xref: RHEA:10140 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047018 +name: indole-3-acetaldehyde reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH." [EC:1.1.1.190, RHEA:14873] +synonym: "(indol-3-yl)ethanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.190] +synonym: "indole-3-ethanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.190] +synonym: "indoleacetaldehyde reductase activity" RELATED [EC:1.1.1.190] +xref: EC:1.1.1.190 +xref: KEGG_REACTION:R02679 +xref: MetaCyc:1.1.1.190-RXN +xref: RHEA:14873 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047019 +name: indole-3-acetaldehyde reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH." [EC:1.1.1.191, RHEA:17037] +synonym: "(indol-3-yl)ethanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.191] +synonym: "indole-3-ethanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.191] +synonym: "indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.191] +xref: EC:1.1.1.191 +xref: KEGG_REACTION:R02680 +xref: MetaCyc:1.1.1.191-RXN +xref: RHEA:17037 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047020 +name: 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate." [EC:1.1.1.196, MetaCyc:1.1.1.196-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.196] +synonym: "15-hydroxy PGD2 dehydrogenase activity" RELATED [EC:1.1.1.196] +synonym: "15-hydroxyprostaglandin dehydrogenase (NADP)" RELATED [EC:1.1.1.196] +synonym: "dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.196] +synonym: "dehydrogenase, prostaglandin D2" RELATED [EC:1.1.1.196] +synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "NADP-linked prostaglandin D2 dehydrogenase activity" RELATED [EC:1.1.1.196] +synonym: "NADP-PGD2 dehydrogenase activity" RELATED [EC:1.1.1.196] +synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.196] +synonym: "prostaglandin D2 dehydrogenase activity" RELATED [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP)" RELATED [EC:1.1.1.196] +synonym: "prostaglandin-D 15-dehydrogenase (NADP+) activity" RELATED [EC:1.1.1.196] +xref: EC:1.1.1.196 +xref: MetaCyc:1.1.1.196-RXN +xref: RHEA:20744 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047021 +name: 15-hydroxyprostaglandin dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH." [EC:1.1.1.197, RHEA:11636] +synonym: "(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.197] +synonym: "NADP-dependent 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "NADP-linked 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "NADP-specific 15-hydroxyprostaglandin dehydrogenase" BROAD [EC:1.1.1.197] +synonym: "type II 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.197] +xref: EC:1.1.1.197 +xref: KEGG_REACTION:R04552 +xref: MetaCyc:1.1.1.197-RXN +xref: RHEA:11636 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047022 +name: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid." [EC:1.1.1.201, MetaCyc:1.1.1.201-RXN] +synonym: "7beta-hydroxysteroid dehydrogenase (NADP+)" RELATED [EC:1.1.1.201] +synonym: "7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity" RELATED [EC:1.1.1.201] +synonym: "NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.201] +synonym: "NADP-dependent 7beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.201] +xref: EC:1.1.1.201 +xref: MetaCyc:1.1.1.201-RXN +xref: RHEA:20233 +xref: Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+) +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047023 +name: androsterone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione." [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] +synonym: "3(17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] +synonym: "3(or 17)-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] +synonym: "3(or 17)alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.209] +synonym: "3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity" BROAD [EC:1.1.1.209] +xref: EC:1.1.1.209 +xref: MetaCyc:1.1.1.209-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047024 +name: 5alpha-androstane-3beta,17beta-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH." [EC:1.1.1.210, RHEA:16297] +synonym: "3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] +synonym: "3-beta-HSD activity" RELATED [EC:1.1.1.210] +synonym: "3beta(or 20alpha)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.210] +synonym: "3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity" BROAD [EC:1.1.1.210] +synonym: "3beta,20alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.210] +synonym: "dehydrogenase, 3beta,20alpha-hydroxy steroid" BROAD [EC:1.1.1.210] +synonym: "progesterone reductase activity" RELATED [EC:1.1.1.210] +xref: EC:1.1.1.210 +xref: KEGG_REACTION:R04344 +xref: MetaCyc:1.1.1.210-RXN +xref: RHEA:16297 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047025 +name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]." [EC:1.1.1.212, MetaCyc:1.1.1.212-RXN] +synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.212] +synonym: "3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [] +synonym: "3-oxoacyl-ACP reductase (NADH) activity" EXACT [] +synonym: "3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.1.1.212] +synonym: "3-oxoacyl-acyl-carrier-protein reductase (NADH)" RELATED [EC:1.1.1.212] +xref: EC:1.1.1.212 +xref: MetaCyc:1.1.1.212-RXN +xref: RHEA:19913 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047026 +name: androsterone dehydrogenase (A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.213, MetaCyc:1.1.1.213-RXN] +synonym: "3-alpha-hydroxysteroid dehydrogenase (A-specific) activity" BROAD [EC:1.1.1.213] +synonym: "3alpha-hydroxysteroid dehydrogenase (A-specific)" BROAD [EC:1.1.1.213] +synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)" BROAD [EC:1.1.1.213] +xref: EC:1.1.1.213 +xref: MetaCyc:1.1.1.213-RXN +xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific) +is_a: GO:0047023 ! androsterone dehydrogenase activity + +[Term] +id: GO:0047027 +name: benzyl-2-methyl-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH." [EC:1.1.1.217, RHEA:16405] +synonym: "benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.217] +synonym: "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.217] +xref: EC:1.1.1.217 +xref: KEGG_REACTION:R04370 +xref: MetaCyc:1.1.1.217-RXN +xref: RHEA:16405 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047028 +name: 6-pyruvoyltetrahydropterin 2'-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin." [EC:1.1.1.220, MetaCyc:1.1.1.220-RXN] +synonym: "6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.1.1.220] +synonym: "6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity" RELATED [EC:1.1.1.220] +synonym: "6-pyruvoyl-tetrahydropterin 2'-reductase activity" RELATED [EC:1.1.1.220] +synonym: "6-pyruvoyltetrahydropterin reductase activity" RELATED [EC:1.1.1.220] +synonym: "6PPH4(2'-oxo) reductase activity" RELATED [EC:1.1.1.220] +synonym: "pyruvoyl-tetrahydropterin reductase activity" RELATED [EC:1.1.1.220] +xref: EC:1.1.1.220 +xref: MetaCyc:1.1.1.220-RXN +xref: RHEA:11772 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047029 +name: (R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate." [RHEA:52692] +synonym: "aromatic 2-oxoacid reductase activity" BROAD [] +synonym: "hydroxyphenylpyruvate reductase activity" BROAD [] +synonym: "phenylpyruvate reductase activity" RELATED [] +xref: https://github.com/geneontology/go-ontology/issues/21412 +xref: MetaCyc:RXN-7632 +xref: RHEA:52692 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047030 +name: 4-hydroxycyclohexanecarboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH." [EC:1.1.1.226, RHEA:17429] +synonym: "trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity" RELATED [EC:1.1.1.226] +synonym: "trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.226] +xref: EC:1.1.1.226 +xref: KEGG_REACTION:R04307 +xref: MetaCyc:1.1.1.226-RXN +xref: RHEA:17429 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047031 +name: diethyl 2-methyl-3-oxosuccinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH." [EC:1.1.1.229, RHEA:21008] +synonym: "diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.229] +xref: EC:1.1.1.229 +xref: KEGG_REACTION:R04387 +xref: MetaCyc:1.1.1.229-RXN +xref: RHEA:21008 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047032 +name: 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH." [EC:1.1.1.230, RHEA:20816] +synonym: "3alpha-hydroxyglycyrrhetinate dehydrogenase activity" RELATED [EC:1.1.1.230] +synonym: "3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.230] +xref: EC:1.1.1.230 +xref: KEGG_REACTION:R04099 +xref: MetaCyc:1.1.1.230-RXN +xref: RHEA:20816 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047033 +name: 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH." [EC:1.1.1.231, RHEA:21420] +synonym: "(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity" RELATED [EC:1.1.1.231] +synonym: "NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.231] +synonym: "NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity" RELATED [EC:1.1.1.231] +synonym: "PG I2 dehydrogenase activity" RELATED [EC:1.1.1.231] +synonym: "prostacyclin dehydrogenase activity" RELATED [EC:1.1.1.231] +xref: EC:1.1.1.231 +xref: KEGG_REACTION:R03520 +xref: MetaCyc:1.1.1.231-RXN +xref: RHEA:21420 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047034 +name: 15-hydroxyicosatetraenoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate." [EC:1.1.1.232, MetaCyc:1.1.1.232-RXN] +synonym: "(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity" RELATED [EC:1.1.1.232] +synonym: "15-hydroxyeicosatetraenoate dehydrogenase activity" RELATED [EC:1.1.1.232] +xref: EC:1.1.1.232 +xref: MetaCyc:1.1.1.232-RXN +xref: Reactome:R-HSA-2161789 "15S-HETE is oxidised to 15-oxoETE by 15-HEDH" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047035 +name: testosterone dehydrogenase (NAD+) activity +namespace: molecular_function +alt_id: GO:0050327 +def: "Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH." [EC:1.1.1.239, MetaCyc:1.1.1.239-RXN] +synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.63] +synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.63] +synonym: "17beta-HSD" RELATED [EC:1.1.1.63] +synonym: "17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity" RELATED [EC:1.1.1.63] +synonym: "3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity" BROAD [EC:1.1.1.239] +synonym: "3alpha(17beta)-HSD" RELATED [EC:1.1.1.239] +synonym: "3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)" BROAD [EC:1.1.1.239] +synonym: "3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.239] +synonym: "3alpha,17beta-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.239] +synonym: "testosterone 17-beta-dehydrogenase (NAD+) activity" EXACT [] +synonym: "testosterone 17b-dehydrogenase activity" EXACT [] +synonym: "testosterone 17beta-dehydrogenase activity" RELATED [EC:1.1.1.63] +xref: EC:1.1.1.239 +xref: KEGG_REACTION:R01836 +xref: MetaCyc:1.1.1.239-RXN +xref: MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN +xref: RHEA:14929 +xref: Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+) +is_a: GO:0030283 ! testosterone dehydrogenase [NAD(P)] activity + +[Term] +id: GO:0047036 +name: codeinone reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH." [EC:1.1.1.247, RHEA:19209] +synonym: "codeine:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.247] +xref: EC:1.1.1.247 +xref: KEGG_REACTION:R05124 +xref: MetaCyc:1.1.1.247-RXN +xref: RHEA:19209 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047037 +name: salutaridine reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine." [EC:1.1.1.248, RHEA:10108] +synonym: "salutaridinol:NADP+ 7-oxidoreductase activity" RELATED [EC:1.1.1.248] +xref: EC:1.1.1.248 +xref: KEGG_REACTION:R04697 +xref: MetaCyc:1.1.1.248-RXN +xref: RHEA:10108 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047038 +name: D-arabinitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.250, RHEA:17389] +synonym: "D-arabinitol 2-dehydrogenase (ribulose-forming) activity" RELATED [EC:1.1.1.250] +synonym: "D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming)" RELATED [EC:1.1.1.250] +xref: EC:1.1.1.250 +xref: KEGG_REACTION:R07134 +xref: MetaCyc:1.1.1.250-RXN +xref: RHEA:17389 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047039 +name: tetrahydroxynaphthalene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol." [EC:1.1.1.252, MetaCyc:1.1.1.252-RXN] +synonym: "scytalone:NADP+ delta5-oxidoreductase activity" RELATED [EC:1.1.1.252] +synonym: "T4HN reductase activity" RELATED [EC:1.1.1.252] +xref: EC:1.1.1.252 +xref: MetaCyc:1.1.1.252-RXN +xref: RHEA:21908 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047040 +name: pteridine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH." [EC:1.5.1.33, RHEA:19509] +comment: Note that this function was formerly EC:1.1.1.253. +synonym: "5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.33] +synonym: "dihydrobiopterin reduction" RELATED [] +synonym: "pteridine reductase 1 activity" NARROW [EC:1.5.1.33e] +synonym: "PTR1" RELATED [EC:1.5.1.33] +synonym: "ptr1 activity" NARROW [EC:1.5.1.33e] +xref: EC:1.5.1.33 +xref: KEGG_REACTION:R01812 +xref: MetaCyc:1.1.1.253-RXN +xref: RHEA:19509 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047041 +name: (S)-carnitine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.254, RHEA:11556] +synonym: "(S)-carnitine:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.254] +synonym: "D-carnitine dehydrogenase activity" RELATED [EC:1.1.1.254] +xref: EC:1.1.1.254 +xref: KEGG_REACTION:R01921 +xref: MetaCyc:1.1.1.254-RXN +xref: RHEA:11556 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047042 +name: androsterone dehydrogenase (B-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+." [EC:1.1.1.50, MetaCyc:1.1.1.50-RXN] +synonym: "3-alpha-HSD activity" RELATED [EC:1.1.1.50] +synonym: "3-alpha-hydroxysteroid dehydrogenase (B-specific) activity" BROAD [EC:1.1.1.50] +synonym: "3alpha-HSD" RELATED [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid dehydrogenase (B-specific)" BROAD [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid oxidoreductase activity" BROAD [EC:1.1.1.50] +synonym: "3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)" BROAD [EC:1.1.1.50] +synonym: "hydroxyprostaglandin dehydrogenase activity" RELATED [EC:1.1.1.50] +synonym: "sterognost 3alpha" RELATED [EC:1.1.1.50] +xref: EC:1.1.1.50 +xref: MetaCyc:1.1.1.50-RXN +xref: Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific) +is_a: GO:0047023 ! androsterone dehydrogenase activity + +[Term] +id: GO:0047043 +name: 3-alpha-hydroxycholanate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.52, RHEA:19585] +synonym: "3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.52] +synonym: "3alpha-hydroxycholanate dehydrogenase activity" RELATED [EC:1.1.1.52] +synonym: "alpha-hydroxy-cholanate dehydrogenase activity" RELATED [EC:1.1.1.52] +xref: EC:1.1.1.52 +xref: KEGG_REACTION:R04139 +xref: MetaCyc:1.1.1.52-RXN +xref: RHEA:19585 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047044 +name: androstan-3-alpha,17-beta-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+." [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] +synonym: "(R)-20-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] +synonym: "20beta-HSD" RELATED [EC:1.1.1.53] +synonym: "20beta-hydroxysteroid dehydrogenase activity" RELATED [EC:1.1.1.53] +synonym: "3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] +synonym: "3alpha(or 20beta)-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] +synonym: "3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity" BROAD [EC:1.1.1.53] +synonym: "3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity" BROAD [EC:1.1.1.53] +synonym: "cortisone reductase activity" RELATED [EC:1.1.1.53] +synonym: "dehydrogenase, 20beta-hydroxy steroid" BROAD [EC:1.1.1.53] +synonym: "delta4-3-ketosteroid hydrogenase activity" BROAD [EC:1.1.1.53] +synonym: "NADH-20beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.53] +xref: EC:1.1.1.53 +xref: MetaCyc:1.1.1.53-RXN +xref: RHEA:22400 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047045 +name: testosterone 17-beta-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione." [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN] +synonym: "17-ketoreductase activity" BROAD [EC:1.1.1.64] +synonym: "17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity" RELATED [EC:1.1.1.64] +synonym: "NADP-dependent testosterone-17beta-oxidoreductase activity" RELATED [EC:1.1.1.64] +synonym: "testosterone 17beta-dehydrogenase (NADP+)" RELATED [EC:1.1.1.64] +xref: EC:1.1.1.64 +xref: KEGG_REACTION:R01838 +xref: MetaCyc:1.1.1.64-RXN +xref: RHEA:14981 +xref: Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+) +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047046 +name: homoisocitrate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0047984 +def: "Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate." [EC:1.1.1.155, EC:1.1.1.87, MetaCyc:1.1.1.87-RXN] +comment: Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. +synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.87] +synonym: "(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87] +synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87] +synonym: "2-hydroxy-3-carboxyadipate dehydrogenase activity" RELATED [EC:1.1.1.87] +synonym: "3-carboxy-2-hydroxyadipate dehydrogenase activity" EXACT [] +synonym: "3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity" RELATED [EC:1.1.1.87] +synonym: "3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.87] +synonym: "homoisocitric dehydrogenase activity" RELATED [EC:1.1.1.87] +xref: EC:1.1.1.87 +xref: MetaCyc:1.1.1.87-RXN +xref: RHEA:11900 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047047 +name: oxaloglycolate reductase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate." [EC:1.1.1.92, MetaCyc:1.1.1.92-RXN] +synonym: "D-glycerate:NAD(P)+ oxidoreductase (carboxylating)" RELATED [EC:1.1.1.92] +xref: EC:1.1.1.92 +xref: MetaCyc:1.1.1.92-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047048 +name: 3-hydroxybenzyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH." [EC:1.1.1.97, RHEA:22340] +synonym: "3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.97] +synonym: "m-hydroxybenzyl alcohol (NADP) dehydrogenase activity" RELATED [EC:1.1.1.97] +synonym: "m-hydroxybenzyl alcohol dehydrogenase activity" RELATED [EC:1.1.1.97] +synonym: "m-hydroxybenzylalcohol dehydrogenase activity" RELATED [EC:1.1.1.97] +xref: EC:1.1.1.97 +xref: KEGG_REACTION:R04136 +xref: MetaCyc:1.1.1.97-RXN +xref: RHEA:22340 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047049 +name: (R)-2-hydroxy-fatty acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.98, RHEA:15949] +synonym: "(R)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] +synonym: "(R)-2-hydroxystearate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.98] +synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.98] +synonym: "D-2-hydroxy fatty acid dehydrogenase activity" RELATED [EC:1.1.1.98] +xref: EC:1.1.1.98 +xref: KEGG_REACTION:R03021 +xref: MetaCyc:1.1.1.98-RXN +xref: RHEA:15949 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047050 +name: (S)-2-hydroxy-fatty acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH." [EC:1.1.1.99, RHEA:11384] +synonym: "(S)-2-hydroxy-fatty-acid dehydrogenase activity" EXACT [] +synonym: "(S)-2-hydroxystearate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.99] +synonym: "2-hydroxy fatty acid oxidase" BROAD [EC:1.1.1.99] +synonym: "dehydrogenase, L-2-hydroxy fatty acid" RELATED [EC:1.1.1.99] +synonym: "L-2-hydroxy fatty acid dehydrogenase activity" RELATED [EC:1.1.1.99] +xref: EC:1.1.1.99 +xref: KEGG_REACTION:R03022 +xref: MetaCyc:1.1.1.99-RXN +xref: RHEA:11384 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047051 +name: D-lactate dehydrogenase (cytochrome c-553) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate." [RHEA:16465] +synonym: "(R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity" RELATED [EC:1.1.2.5] +xref: EC:1.1.2.5 +xref: MetaCyc:1.1.2.5-RXN +xref: RHEA:16465 +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0047052 +name: (S)-stylopine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:13773] +synonym: "(S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity" RELATED [EC:1.14.19.64] +synonym: "(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" RELATED [EC:1.14.19.64] +xref: EC:1.14.19.64 +xref: KEGG_REACTION:R04690 +xref: MetaCyc:1.1.3.32-RXN +xref: RHEA:13773 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0047053 +name: (S)-cheilanthifoline synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:20485] +synonym: "(S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity" EXACT [] +synonym: "(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming)" RELATED [EC:1.14.19.65] +xref: EC:1.14.19.65 +xref: KEGG_REACTION:R03834 +xref: MetaCyc:1.14.21.2-RXN +xref: RHEA:20485 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0047054 +name: berbamunine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 <=> berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:23576] +synonym: "heme-thiolate" RELATED [EC:1.14.19.66] +xref: EC:1.14.19.66 +xref: MetaCyc:1.1.3.34-RXN +xref: RHEA:23576 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0047055 +name: salutaridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:17713] +synonym: "(R)-reticuline oxidase (C-C phenol-coupling) activity" RELATED [] +xref: EC:1.14.19.67 +xref: KEGG_REACTION:R04696 +xref: MetaCyc:1.1.3.35-RXN +xref: RHEA:17713 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0047056 +name: (S)-canadine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [RHEA:21456] +synonym: "(S)-tetrahydroberberine synthase activity" RELATED [EC:1.14.19.68] +synonym: "(S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity" RELATED [EC:1.14.19.68] +xref: EC:1.14.19.68 +xref: KEGG_REACTION:R04400 +xref: MetaCyc:1.1.3.36-RXN +xref: RHEA:21456 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0047057 +name: vitamin-K-epoxide reductase (warfarin-sensitive) activity +namespace: molecular_function +def: "Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues." [RHEA:57744] +comment: Formerly EC:1.1.4.1. +synonym: "phylloquinone epoxide reductase activity" RELATED [EC:1.17.4.4] +synonym: "vitamin K1 epoxide reductase activity" NARROW [EC:1.17.4.4] +xref: EC:1.17.4.4 +xref: MetaCyc:1.1.4.1-RXN +xref: Reactome:R-HSA-159790 "VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)" +xref: Reactome:R-HSA-6806647 "VKORC1L1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)" +xref: RHEA:57744 +is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor + +[Term] +id: GO:0047058 +name: vitamin-K-epoxide reductase (warfarin-insensitive) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol." [RHEA:21560] +comment: Formerly EC:1.1.4.2. +synonym: "vitamin K 2,3-epoxide reductase activity" RELATED [EC:1.17.4.5] +xref: EC:1.17.4.5 +xref: MetaCyc:1.1.4.2-RXN +xref: RHEA:21560 +is_a: GO:0016900 ! oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor + +[Term] +id: GO:0047059 +name: polyvinyl alcohol dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+." [EC:1.1.2.6] +comment: Formerly EC:1.1.99.23. +synonym: "polyvinyl alcohol:ferricytochrome-c oxidoreductase activity" EXACT [] +synonym: "polyvinyl-alcohol:(acceptor) oxidoreductase activity" BROAD [] +synonym: "polyvinyl-alcohol:acceptor oxidoreductase activity" BROAD [] +synonym: "PVA dehydrogenase activity" BROAD [EC:1.1.2.6] +xref: EC:1.1.2.6 +xref: KEGG_REACTION:R03136 +xref: MetaCyc:RXN-11316 +xref: RHEA:20157 +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0047060 +name: (R)-pantolactone dehydrogenase (flavin) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2)." [EC:1.1.99.27, RHEA:21004] +synonym: "(R)-pantolactone:acceptor oxidoreductase (flavin-containing)" RELATED [EC:1.1.99.27] +synonym: "(R)-pantoyllactone dehydrogenase (flavin) activity" RELATED [EC:1.1.99.27] +synonym: "2-dehydropantolactone reductase (flavin) activity" RELATED [EC:1.1.99.27] +synonym: "2-dehydropantoyl-lactone reductase (flavin) activity" RELATED [EC:1.1.99.27] +xref: EC:1.1.99.27 +xref: KEGG_REACTION:R03156 +xref: MetaCyc:1.1.99.27-RXN +xref: RHEA:21004 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047061 +name: glucose-fructose oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone." [EC:1.1.99.28, RHEA:20637] +synonym: "D-glucose:D-fructose oxidoreductase activity" RELATED [EC:1.1.99.28] +xref: EC:1.1.99.28 +xref: KEGG_REACTION:R00874 +xref: MetaCyc:1.1.99.28-RXN +xref: RHEA:20637 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047062 +name: trans-acenaphthene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH." [EC:1.10.1.1, RHEA:22184] +synonym: "(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.10.1.1] +synonym: "trans-1,2-acenaphthenediol dehydrogenase activity" RELATED [EC:1.10.1.1] +xref: EC:1.10.1.1 +xref: KEGG_REACTION:R04059 +xref: MetaCyc:1.10.1.1-RXN +xref: RHEA:22184 +is_a: GO:0016680 ! oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor + +[Term] +id: GO:0047063 +name: obsolete L-ascorbate-cytochrome-b5 reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ferricytochrome B5 + ascorbate = ferrocytochrome B5 + monodehydroascorbate." [GOC:curators] +comment: This term was obsoleted because the EC (EC:1.10.2.1) and RHEA (RHEA:18677) it represented was obsoleted. +synonym: "ascorbate-cytochrome b5 reductase activity" RELATED [EC:1.10.2.1] +synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" RELATED [EC:1.10.2.1] +xref: MetaCyc:1.10.2.1-RXN +is_obsolete: true + +[Term] +id: GO:0047064 +name: sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.4, RHEA:24092] +synonym: "sulochrin oxidase activity" RELATED [EC:1.21.3.4] +synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)" RELATED [EC:1.21.3.4] +xref: EC:1.21.3.4 +xref: KEGG_REACTION:R00060 +xref: MetaCyc:1.10.3.7-RXN +xref: RHEA:24092 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0047065 +name: sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O." [EC:1.21.3.5, RHEA:22616] +synonym: "sulochrin oxidase activity" BROAD [EC:1.21.3.5] +synonym: "sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)" RELATED [EC:1.21.3.5] +xref: EC:1.21.3.5 +xref: KEGG_REACTION:R00061 +xref: MetaCyc:1.10.3.8-RXN +xref: RHEA:22616 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0047066 +name: phospholipid-hydroperoxide glutathione peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione." [EC:1.11.1.12, MetaCyc:1.11.1.12-RXN] +synonym: "glutathione:lipid-hydroperoxide oxidoreductase activity" RELATED [EC:1.11.1.12] +synonym: "hydroperoxide glutathione peroxidase activity" RELATED [EC:1.11.1.12] +synonym: "peroxidation-inhibiting protein activity" RELATED [EC:1.11.1.12] +synonym: "peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)" RELATED [EC:1.11.1.12] +synonym: "PHGPX" RELATED [EC:1.11.1.12] +synonym: "phospholipid hydroperoxide glutathione peroxidase activity" RELATED [EC:1.11.1.12] +xref: EC:1.11.1.12 +xref: MetaCyc:1.11.1.12-RXN +xref: Reactome:R-HSA-9018868 "GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE" +xref: Reactome:R-HSA-9018895 "GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE" +xref: Reactome:R-HSA-9020271 "GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA" +xref: Reactome:R-HSA-9020273 "GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA" +xref: RHEA:19057 +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0047067 +name: hydrogen:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone." [EC:1.12.5.1, RHEA:18641] +synonym: "hydrogen-ubiquinone oxidoreductase activity" RELATED [EC:1.12.5.1] +synonym: "hydrogen:menaquinone oxidoreductase activity" RELATED [EC:1.12.5.1] +synonym: "membrane-bound hydrogenase activity" NARROW [EC:1.12.5.1] +synonym: "quinone-reactive Ni/Fe-hydrogenase activity" RELATED [EC:1.12.5.1] +xref: EC:1.12.5.1 +xref: KEGG_REACTION:R02965 +xref: MetaCyc:1.12.5.1-RXN +xref: RHEA:18641 +is_a: GO:0046994 ! oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor + +[Term] +id: GO:0047068 +name: N5,N10-methenyltetrahydromethanopterin hydrogenase activity +namespace: molecular_function +alt_id: GO:0016947 +def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+)." [EC:1.12.98.2, RHEA:20017] +synonym: "5,10-methenyltetrahydromethanopterin hydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "H(2)-dependent methylene-H(4)MPT dehydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "H2-dependent methylene-H4MPT dehydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2] +synonym: "hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2] +synonym: "hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity" RELATED [EC:1.12.98.2] +synonym: "N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity" RELATED [EC:1.12.98.2] +synonym: "N5,N10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [] +synonym: "nonmetal hydrogenase activity" RELATED [EC:1.12.98.2] +xref: EC:1.12.98.2 +xref: KEGG_REACTION:R04455 +xref: MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN +xref: RHEA:20017 +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0047069 +name: 7,8-dihydroxykynurenate 8,8a-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+)." [EC:1.13.11.10, RHEA:23400] +synonym: "7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity" RELATED [EC:1.13.11.10] +synonym: "7,8-dihydroxykynurenate oxygenase activity" RELATED [EC:1.13.11.10] +synonym: "7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.10] +synonym: "7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.10] +xref: EC:1.13.11.10 +xref: KEGG_REACTION:R03253 +xref: MetaCyc:1.13.11.10-RXN +xref: RHEA:23400 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047070 +name: 3-carboxyethylcatechol 2,3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0008669 +def: "Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate." [EC:1.13.11.16, MetaCyc:1.13.11.16-RXN] +synonym: "2,3-dihydroxy-beta-phenylpropionate oxygenase activity" RELATED [EC:1.13.11.16] +synonym: "2,3-dihydroxy-beta-phenylpropionic dioxygenase activity" RELATED [EC:1.13.11.16] +synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.16] +synonym: "3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity" RELATED [EC:1.13.11.16] +xref: EC:1.13.11.16 +xref: MetaCyc:1.13.11.16-RXN +xref: RHEA:23840 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047071 +name: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+)." [EC:1.13.11.25, RHEA:21352] +synonym: "3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.25] +synonym: "3-alkylcatechol 2,3-dioxygenase activity" RELATED [EC:1.13.11.25] +synonym: "steroid 4,5-dioxygenase activity" BROAD [EC:1.13.11.25] +xref: EC:1.13.11.25 +xref: KEGG_REACTION:R04597 +xref: MetaCyc:1.13.11.25-RXN +xref: RHEA:21352 +xref: UM-BBD_reactionID:r1151 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047072 +name: 2,3-dihydroxybenzoate 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+)." [EC:1.13.11.28, RHEA:15369] +synonym: "2,3-dihydroxybenzoate 2,3-oxygenase activity" RELATED [EC:1.13.11.28] +synonym: "2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.28] +xref: EC:1.13.11.28 +xref: KEGG_REACTION:R01506 +xref: MetaCyc:1.13.11.28-RXN +xref: RHEA:15369 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047073 +name: 2,4'-dihydroxyacetophenone dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+)." [EC:1.13.11.41, RHEA:24416] +synonym: "(4-hydroxybenzoyl)methanol oxygenase activity" RELATED [EC:1.13.11.41] +synonym: "2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)" RELATED [EC:1.13.11.41] +xref: EC:1.13.11.41 +xref: KEGG_REACTION:R01305 +xref: MetaCyc:1.13.11.41-RXN +xref: RHEA:24416 +xref: UM-BBD_reactionID:r1410 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047074 +name: 4-hydroxycatechol 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." [RHEA:35595] +xref: EC:1.13.11.37 +xref: MetaCyc:R308-RXN +xref: MetaCyc:RXN-10137 +xref: RHEA:35595 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047075 +name: 2,5-dihydroxypyridine 5,6-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate." [EC:1.13.11.9, MetaCyc:1.13.11.9-RXN] +synonym: "2,5-dihydroxypyridine oxygenase activity" RELATED [EC:1.13.11.9] +synonym: "2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity" RELATED [EC:1.13.11.9] +synonym: "pyridine-2,5-diol dioxygenase activity" RELATED [EC:1.13.11.9] +xref: EC:1.13.11.9 +xref: MetaCyc:1.13.11.9-RXN +xref: RHEA:27522 +xref: UM-BBD_reactionID:r1443 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047077 +name: Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." [EC:1.13.12.7, MetaCyc:1.13.12.7-RXN] +synonym: "firefly luciferase activity" RELATED [EC:1.13.12.7] +synonym: "firefly luciferin luciferase activity" RELATED [EC:1.13.12.7] +synonym: "luciferase (firefly luciferin)" RELATED [EC:1.13.12.7] +synonym: "luciferase activity" BROAD [EC:1.13.12.7] +synonym: "Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)" RELATED [EC:1.13.12.7] +synonym: "Photinus pyralis luciferase activity" RELATED [EC:1.13.12.7] +synonym: "Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)" RELATED [EC:1.13.12.7] +synonym: "Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)" RELATED [EC:1.13.12.7] +xref: EC:1.13.12.7 +xref: MetaCyc:1.13.12.7-RXN +xref: RHEA:10732 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047078 +name: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate." [EC:1.13.11.47, MetaCyc:1.13.11.47-RXN] +synonym: "(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" RELATED [EC:1.13.11.47] +synonym: "1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity" EXACT [] +synonym: "3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" RELATED [EC:1.13.11.47] +synonym: "3-hydroxy-4(1H)-one, 2,4-dioxygenase activity" RELATED [EC:1.13.11.47] +synonym: "3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity" RELATED [EC:1.13.11.47] +synonym: "quinoline-3,4-diol 2,4-dioxygenase activity" RELATED [EC:1.13.11.47] +xref: EC:1.13.11.47 +xref: MetaCyc:1.13.11.47-RXN +xref: RHEA:17949 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047079 +name: deoxyuridine 1'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil." [EC:1.14.11.10, RHEA:23316] +synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)" RELATED [EC:1.14.11.10] +synonym: "pyrimidine-deoxynucleoside 1'-dioxygenase activity" BROAD [EC:1.14.11.10] +synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity" BROAD [EC:1.14.11.10] +xref: EC:1.14.11.10 +xref: KEGG_REACTION:R02486 +xref: MetaCyc:1.14.11.10-RXN +xref: RHEA:23316 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0047080 +name: deoxyuridine 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine." [EC:1.14.11.3, RHEA:21076] +synonym: "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)" RELATED [EC:1.14.11.3] +synonym: "deoxyuridine 2'-hydroxylase activity" RELATED [EC:1.14.11.3] +synonym: "pyrimidine deoxyribonucleoside 2'-hydroxylase activity" BROAD [EC:1.14.11.3] +synonym: "pyrimidine-deoxynucleoside 2'-dioxygenase activity" BROAD [EC:1.14.11.3] +synonym: "pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity" BROAD [EC:1.14.11.3] +synonym: "thymidine 2'-dioxygenase activity" NARROW [EC:1.14.11.3] +synonym: "thymidine 2'-hydroxylase activity" RELATED [EC:1.14.11.3] +synonym: "thymidine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.3] +synonym: "thymidine dioxygenase activity" RELATED [EC:1.14.11.3] +xref: EC:1.14.11.3 +xref: KEGG_REACTION:R01879 +xref: MetaCyc:1.14.11.3-RXN +xref: RHEA:21076 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0047081 +name: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate." [EC:1.14.13.242, MetaCyc:1.14.12.4-RXN] +synonym: "2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity" RELATED [EC:1.14.13.242] +synonym: "3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing)" RELATED [EC:1.14.13.242] +synonym: "3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity" RELATED [EC:1.14.13.242] +synonym: "methylhydroxypyridine carboxylate dioxygenase activity" RELATED [EC:1.14.13.242] +synonym: "methylhydroxypyridinecarboxylate oxidase activity" RELATED [EC:1.14.13.242] +xref: EC:1.14.13.242 +xref: MetaCyc:1.14.12.4-RXN +xref: RHEA:10864 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0047082 +name: 3,9-dihydroxypterocarpan 6a-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol." [EC:1.14.14.93, RHEA:15321] +synonym: "(6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)" RELATED [EC:1.14.14.93] +synonym: "3,9-dihydroxypterocarpan 6a-hydroxylase activity" EXACT [] +synonym: "3,9-dihydroxypterocarpan 6alpha-monooxygenase" RELATED [] +xref: EC:1.14.14.93 +xref: KEGG_REACTION:R03452 +xref: MetaCyc:RXN-4505 +xref: RHEA:15321 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047083 +name: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate." [EC:1.14.14.96, MetaCyc:1.14.13.36-RXN] +synonym: "5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity" EXACT [] +synonym: "coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity" RELATED [EC:1.14.14.96] +synonym: "trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.96] +xref: EC:1.14.14.96 +xref: MetaCyc:1.14.13.36-RXN +xref: RHEA:16265 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047084 +name: methyltetrahydroprotoberberine 14-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine." [EC:1.14.14.97, MetaCyc:1.14.13.37-RXN] +synonym: "(S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity" RELATED [EC:1.14.14.97] +synonym: "(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity" RELATED [EC:1.14.14.97] +synonym: "(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating)" RELATED [EC:1.14.14.97] +synonym: "methyltetrahydroprotoberberine 14-hydroxylase activity" EXACT [] +xref: EC:1.14.14.97 +xref: MetaCyc:1.14.13.37-RXN +xref: RHEA:23684 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047085 +name: hydroxyphenylacetonitrile 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+)." [RHEA:23740] +synonym: "4-hydroxyphenylacetonitrile hydroxylase activity" EXACT [] +synonym: "4-hydroxyphenylacetonitrile monooxygenase activity" EXACT [] +synonym: "4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [] +xref: KEGG_REACTION:R02708 +xref: MetaCyc:1.14.13.42-RXN +xref: RHEA:23740 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047086 +name: ketosteroid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate." [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN] +synonym: "17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)" RELATED [EC:1.14.13.54] +synonym: "androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)" RELATED [EC:1.14.13.54] +synonym: "ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)" RELATED [EC:1.14.13.54] +synonym: "progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)" RELATED [EC:1.14.13.54] +synonym: "steroid-ketone monooxygenase activity" RELATED [EC:1.14.13.54] +xref: EC:1.14.13.54 +xref: MetaCyc:1.14.13.54-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047087 +name: protopine 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+)." [EC:1.14.14.98, RHEA:22644] +synonym: "protopine 6-hydroxylase activity" EXACT [] +synonym: "protopine,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.14.98] +xref: EC:1.14.14.98 +xref: KEGG_REACTION:R04699 +xref: MetaCyc:1.14.13.55-RXN +xref: RHEA:22644 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047088 +name: dihydrosanguinarine 10-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+)." [EC:1.14.14.100, RHEA:10528] +synonym: "dihydrosanguinarine 10-hydroxylase activity" EXACT [] +synonym: "dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)" RELATED [EC:1.14.14.100] +xref: EC:1.14.14.100 +xref: KEGG_REACTION:R04702 +xref: MetaCyc:1.14.13.56-RXN +xref: RHEA:10528 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047089 +name: dihydrochelirubine 12-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+)." [EC:1.14.14.101, RHEA:10156] +synonym: "dihydrochelirubine 12-hydroxylase activity" EXACT [] +synonym: "dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)" RELATED [EC:1.14.14.101] +xref: EC:1.14.14.101 +xref: KEGG_REACTION:R04708 +xref: MetaCyc:1.14.13.57-RXN +xref: RHEA:10156 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047090 +name: benzoyl-CoA 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+)." [EC:1.14.13.58, RHEA:23216] +synonym: "benzoyl-CoA 3-hydroxylase activity" EXACT [] +synonym: "benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.58] +xref: EC:1.14.13.58 +xref: KEGG_REACTION:R02449 +xref: MetaCyc:1.14.13.58-RXN +xref: RHEA:23216 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047091 +name: L-lysine 6-monooxygenase (NADPH) activity +namespace: molecular_function +alt_id: GO:0008739 +def: "Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+)." [EC:1.14.13.59, RHEA:23228] +comment: Note that EC:1.13.12.10 was merged into this term. +synonym: "L-lysine 6-monooxygenase activity" EXACT [] +synonym: "L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.59] +synonym: "lysine N(6)-hydroxylase activity" RELATED [EC:1.14.13.59] +synonym: "lysine N6-hydroxylase activity" EXACT [] +xref: EC:1.14.13.59 +xref: KEGG_REACTION:R00448 +xref: MetaCyc:1.14.13.59-RXN +xref: RHEA:23228 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047092 +name: 27-hydroxycholesterol 7-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol." [RHEA:24308] +synonym: "27-hydroxycholesterol 7-alpha-hydroxylase activity" RELATED [EC:1.14.14.29] +synonym: "27-hydroxycholesterol 7a-hydroxylase activity" EXACT [] +synonym: "27-hydroxycholesterol 7alpha-hydroxylase activity" RELATED [EC:1.14.14.29] +synonym: "27-hydroxycholesterol 7alpha-monooxygenase activity" RELATED [EC:1.14.14.29] +synonym: "27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [] +xref: EC:1.14.14.29 +xref: MetaCyc:1.14.13.60-RXN +xref: RHEA:24308 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047093 +name: 4-hydroxyquinoline 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol." [EC:1.14.13.62, RHEA:19325] +synonym: "1-H-4-oxoquinoline 3-monooxygenase activity" RELATED [EC:1.14.13.62] +synonym: "quinolin-4(1H)-one 3-monooxygenase activity" RELATED [EC:1.14.13.62] +synonym: "quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)" RELATED [EC:1.14.13.62] +xref: EC:1.14.13.62 +xref: KEGG_REACTION:R05154 +xref: MetaCyc:1.14.13.62-RXN +xref: RHEA:19325 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047094 +name: 3-hydroxyphenylacetate 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate." [EC:1.14.13.63, MetaCyc:1.14.13.63-RXN] +synonym: "3-hydroxyphenylacetate 6-monooxygenase activity" RELATED [EC:1.14.13.63] +synonym: "3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.63] +xref: EC:1.14.13.63 +xref: MetaCyc:1.14.13.63-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047095 +name: 2-hydroxycyclohexanone 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+)." [EC:1.14.13.66, RHEA:33283] +synonym: "2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing)" RELATED [EC:1.14.13.66] +xref: EC:1.14.13.66 +xref: KEGG_REACTION:R03281 +xref: MetaCyc:1.14.13.66-RXN +xref: RHEA:33283 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047096 +name: androst-4-ene-3,17-dione monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone." [EC:1.14.99.12, RHEA:22696] +synonym: "4-androstene-3,17-dione monooxygenase activity" EXACT [] +synonym: "androst-4-ene-3,17-dione 17-oxidoreductase activity" RELATED [EC:1.14.99.12] +synonym: "androst-4-ene-3,17-dione hydroxylase activity" RELATED [EC:1.14.99.12] +synonym: "androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)" RELATED [EC:1.14.99.12] +synonym: "androstene-3,17-dione hydroxylase activity" EXACT [] +synonym: "androstenedione monooxygenase activity" RELATED [EC:1.14.99.12] +xref: EC:1.14.99.12 +xref: KEGG_REACTION:R01833 +xref: MetaCyc:1.14.99.12-RXN +xref: RHEA:22696 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047097 +name: phylloquinone monooxygenase (2,3-epoxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O." [EC:1.14.99.20, RHEA:16745] +synonym: "phylloquinone epoxidase activity" RELATED [EC:1.14.99.20] +synonym: "phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" RELATED [EC:1.14.99.20] +synonym: "vitamin K 2,3-epoxidase activity" RELATED [EC:1.14.99.20] +synonym: "vitamin K epoxidase activity" RELATED [EC:1.14.99.20] +synonym: "vitamin K1 epoxidase activity" RELATED [EC:1.14.99.20] +xref: EC:1.14.99.20 +xref: KEGG_REACTION:R03510 +xref: MetaCyc:1.14.99.20-RXN +xref: RHEA:16745 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047098 +name: Latia-luciferin monooxygenase (demethylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin." [EC:1.14.99.21, MetaCyc:1.14.99.21-RXN] +synonym: "Latia luciferin monooxygenase (demethylating)" RELATED [EC:1.14.99.21] +synonym: "Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)" RELATED [EC:1.14.99.21] +synonym: "luciferase (Latia luciferin)" RELATED [EC:1.14.99.21] +xref: EC:1.14.99.21 +xref: MetaCyc:1.14.99.21-RXN +xref: RHEA:12677 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047099 +name: CDP-4-dehydro-6-deoxyglucose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose." [EC:1.17.1.1, MetaCyc:1.17.1.1-RXN] +synonym: "CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity" RELATED [EC:1.17.1.1] +synonym: "CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity" RELATED [EC:1.17.1.1] +synonym: "CDP-4-keto-6-deoxyglucose reductase activity" RELATED [EC:1.17.1.1] +synonym: "CDP-4-keto-deoxy-glucose reductase activity" RELATED [EC:1.17.1.1] +synonym: "cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity" RELATED [EC:1.17.1.1] +synonym: "cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity" RELATED [EC:1.17.1.1] +synonym: "NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity" RELATED [EC:1.17.1.1] +xref: EC:1.17.1.1 +xref: MetaCyc:1.17.1.1-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0047100 +name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate." [EC:1.2.1.13, MetaCyc:1.2.1.13-RXN] +synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)" RELATED [EC:1.2.1.13] +synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" RELATED [EC:1.2.1.13] +synonym: "glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)" RELATED [EC:1.2.1.13] +synonym: "NADP-dependent glyceraldehyde phosphate dehydrogenase activity" RELATED [EC:1.2.1.13] +synonym: "NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity" RELATED [EC:1.2.1.13] +synonym: "NADP-triose phosphate dehydrogenase activity" RELATED [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP(+)) activity" RELATED [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP)" RELATED [EC:1.2.1.13] +synonym: "triosephosphate dehydrogenase (NADP+) activity" RELATED [EC:1.2.1.13] +xref: EC:1.2.1.13 +xref: MetaCyc:1.2.1.13-RXN +xref: RHEA:10296 +is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity + +[Term] +id: GO:0047101 +name: 2-oxoisovalerate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA." [EC:1.2.1.25, MetaCyc:1.2.1.25-RXN] +synonym: "2-oxoisovalerate dehydrogenase activity" RELATED [EC:1.2.1.25] +synonym: "3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)" RELATED [EC:1.2.1.25] +xref: EC:1.2.1.25 +xref: MetaCyc:1.2.1.25-RXN +xref: RHEA:13997 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047102 +name: aminomuconate-semialdehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate." [EC:1.2.1.32, MetaCyc:1.2.1.32-RXN] +synonym: "2-aminomuconate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +synonym: "2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity" RELATED [EC:1.2.1.32] +synonym: "2-hydroxymuconate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +synonym: "2-hydroxymuconic acid semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +synonym: "2-hydroxymuconic semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +synonym: "alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +synonym: "alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.32] +xref: EC:1.2.1.32 +xref: MetaCyc:1.2.1.32-RXN +xref: Reactome:R-HSA-71239 "2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+" +xref: RHEA:14469 +xref: UM-BBD_reactionID:r1434 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047103 +name: 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate." [PMID:8496170, RHEA:34627] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity" EXACT [] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity" EXACT [] +synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity" EXACT [] +synonym: "3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity" EXACT [] +synonym: "cholestanetriol-26-al 26-dehydrogenase activity" RELATED [] +synonym: "THAL-NAD oxidoreductase activity" EXACT [] +synonym: "trihydroxydeoxycoprostanal dehydrogenase activity" EXACT [] +xref: EC:1.14.15.15 +xref: MetaCyc:1.2.1.40-RXN +xref: RHEA:34627 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047104 +name: hexadecanal dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA." [EC:1.2.1.42, RHEA:19705] +synonym: "fatty acyl-CoA reductase activity" BROAD [EC:1.2.1.42] +synonym: "hexadecanal:NAD+ oxidoreductase (CoA-acylating)" RELATED [EC:1.2.1.42] +xref: EC:1.2.1.42 +xref: KEGG_REACTION:R01277 +xref: MetaCyc:1.2.1.42-RXN +xref: RHEA:19705 +xref: UM-BBD_reactionID:r1374 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047105 +name: 4-trimethylammoniobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate." [EC:1.2.1.47, MetaCyc:1.2.1.47-RXN] +synonym: "4-N-trimethylaminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.47] +synonym: "4-trimethylaminobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.47] +synonym: "4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.47] +xref: EC:1.2.1.47 +xref: MetaCyc:1.2.1.47-RXN +xref: RHEA:17985 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047106 +name: 4-hydroxyphenylacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate." [EC:1.2.1.53, MetaCyc:1.2.1.53-RXN] +synonym: "4-HPAL dehydrogenase activity" RELATED [EC:1.2.1.53] +synonym: "4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.53] +xref: EC:1.2.1.53 +xref: MetaCyc:1.2.1.53-RXN +xref: RHEA:17273 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0047107 +name: gamma-guanidinobutyraldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH." [EC:1.2.1.54, RHEA:14381] +synonym: "4-guanidinobutanal:NAD+ 1-oxidoreductase activity" RELATED [EC:1.2.1.54] +synonym: "4-guanidinobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.54] +synonym: "alpha-guanidinobutyraldehyde dehydrogenase activity" RELATED [EC:1.2.1.54] +synonym: "GBAL dehydrogenase activity" RELATED [EC:1.2.1.54] +xref: EC:1.2.1.54 +xref: KEGG_REACTION:R03177 +xref: MetaCyc:1.2.1.54-RXN +xref: RHEA:14381 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0047108 +name: (R)-3-hydroxyacid-ester dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.279, RHEA:24352] +comment: Note that this term was EC:1.2.1.55. +synonym: "(R)-3-hydroxyacid ester dehydrogenase activity" EXACT [] +synonym: "3-oxo ester (R)-reductase activity" RELATED [EC:1.1.1.279] +synonym: "ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.279] +xref: EC:1.1.1.279 +xref: KEGG_REACTION:R04105 +xref: MetaCyc:1.2.1.55-RXN +xref: RHEA:24352 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047109 +name: (S)-3-hydroxyacid-ester dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH." [EC:1.1.1.280, RHEA:18269] +comment: Note that this term was EC:1.2.1.56. +synonym: "(S)-3-hydroxyacid ester dehydrogenase activity" EXACT [] +synonym: "3-oxo ester (S)-reductase activity" RELATED [EC:1.1.1.280] +synonym: "ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.280] +xref: EC:1.1.1.280 +xref: KEGG_REACTION:R04106 +xref: MetaCyc:1.2.1.56-RXN +xref: RHEA:18269 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047110 +name: phenylglyoxylate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH." [EC:1.2.1.58, RHEA:10372] +synonym: "phenylglyoxylate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.58] +xref: EC:1.2.1.58 +xref: KEGG_REACTION:R02450 +xref: MetaCyc:1.2.1.58-RXN +xref: RHEA:10372 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047111 +name: formate dehydrogenase (cytochrome-c-553) activity +namespace: molecular_function +def: "Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2." [EC:1.17.2.3, MetaCyc:1.2.2.3-RXN] +synonym: "formate dehydrogenase (cytochrome c-553)" RELATED [EC:1.17.2.3] +synonym: "formate:ferricytochrome-c-553 oxidoreductase activity" RELATED [EC:1.17.2.3] +xref: EC:1.17.2.3 +xref: MetaCyc:1.2.2.3-RXN +xref: RHEA:15189 +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0047112 +name: pyruvate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2)." [EC:1.2.3.3, RHEA:20848] +synonym: "phosphate-dependent pyruvate oxidase activity" RELATED [EC:1.2.3.3] +synonym: "pyruvate:oxygen 2-oxidoreductase (phosphorylating)" RELATED [EC:1.2.3.3] +synonym: "pyruvic oxidase activity" RELATED [EC:1.2.3.3] +xref: EC:1.2.3.3 +xref: KEGG_REACTION:R00207 +xref: MetaCyc:1.2.3.3-RXN +xref: RHEA:20848 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0047113 +name: aldehyde dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol." [EC:1.2.5.2, MetaCyc:1.2.99.3-RXN] +synonym: "aldehyde dehydrogenase (acceptor) activity" RELATED [EC:1.2.99.3] +synonym: "aldehyde dehydrogenase (pyrroloquinoline-quinone)" RELATED [] +synonym: "aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity" RELATED [EC:1.2.99.3] +xref: EC:1.2.5.2 +xref: MetaCyc:1.2.99.3-RXN +xref: RHEA:13881 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047114 +name: kynurenate-7,8-dihydrodiol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH." [EC:1.3.1.18, RHEA:22248] +synonym: "7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity" RELATED [EC:1.3.1.18] +synonym: "7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.18] +synonym: "7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity" RELATED [EC:1.3.1.18] +xref: EC:1.3.1.18 +xref: KEGG_REACTION:R03251 +xref: MetaCyc:1.3.1.18-RXN +xref: RHEA:22248 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047115 +name: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol." [EC:1.3.1.20, MetaCyc:1.3.1.20-RXN] +synonym: "dihydrodiol dehydrogenase activity" RELATED [EC:1.3.1.20] +synonym: "trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.20] +xref: EC:1.3.1.20 +xref: MetaCyc:1.3.1.20-RXN +xref: RHEA:16729 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047116 +name: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol." [EC:1.3.1.25, MetaCyc:1.3.1.25-RXN] +synonym: "(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.25] +synonym: "2-hydro-1,2-dihydroxybenzoate dehydrogenase activity" RELATED [EC:1.3.1.25] +synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity" RELATED [EC:1.3.1.25] +synonym: "3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity" RELATED [EC:1.3.1.25] +synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity" RELATED [EC:1.3.1.25] +synonym: "cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.25] +synonym: "DHB dehydrogenase activity" RELATED [EC:1.3.1.25] +synonym: "DHBDH activity" RELATED [EC:1.3.1.25] +synonym: "dihydrodihydroxybenzoate dehydrogenase activity" RELATED [EC:1.3.1.25] +xref: EC:1.3.1.25 +xref: MetaCyc:1.3.1.25-RXN +xref: RHEA:11560 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047117 +name: enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.39, MetaCyc:1.3.1.39-RXN] +synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific)" RELATED [EC:1.3.1.39] +synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity" EXACT [] +synonym: "enoyl-ACP reductase (NADPH, A-specific) activity" EXACT [] +synonym: "enoyl-ACp reductase activity" RELATED [EC:1.3.1.39] +synonym: "enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.39] +synonym: "enoyl-acyl-carrier-protein reductase (NADPH, A-specific)" RELATED [EC:1.3.1.39] +xref: EC:1.3.1.39 +xref: MetaCyc:1.3.1.39-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047118 +name: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH." [EC:1.3.1.40, RHEA:24268] +synonym: "2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.40] +synonym: "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.3.1.40] +xref: EC:1.3.1.40 +xref: KEGG_REACTION:R03463 +xref: MetaCyc:1.3.1.40-RXN +xref: RHEA:24268 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047119 +name: 2-methyl-branched-chain-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH." [PMID:10989435, PMID:6401712, RHEA:43780] +synonym: "2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity" RELATED [EC:1.3.1.52] +xref: EC:1.3.8.5 +xref: KEGG_REACTION:R03169 +xref: MetaCyc:1.3.1.52-RXN +xref: RHEA:43780 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047120 +name: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0018514 +def: "Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH." [EC:1.3.1.53, RHEA:10744] +synonym: "(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" RELATED [EC:1.3.1.53] +synonym: "(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.53] +synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.53] +synonym: "dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity" RELATED [EC:1.3.1.53] +synonym: "terephthalate 1,2-cis-dihydrodiol dehydrogenase activity" EXACT [] +xref: EC:1.3.1.53 +xref: KEGG_REACTION:R01633 +xref: MetaCyc:1.3.1.53-RXN +xref: RHEA:10744 +xref: UM-BBD_reactionID:r0151 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047121 +name: isoquinoline 1-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one." [EC:1.3.99.16, RHEA:11588] +synonym: "isoquinoline:acceptor 1-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.16] +xref: EC:1.3.99.16 +xref: KEGG_REACTION:R05151 +xref: MetaCyc:1.3.99.16-RXN +xref: RHEA:11588 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047122 +name: quinaldate 4-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate." [EC:1.3.99.18, RHEA:16697] +synonym: "quinaldic acid 4-oxidoreductase activity" RELATED [EC:1.3.99.18] +synonym: "quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.18] +xref: EC:1.3.99.18 +xref: KEGG_REACTION:R03687 +xref: MetaCyc:1.3.99.18-RXN +xref: RHEA:16697 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047123 +name: quinoline-4-carboxylate 2-oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2)." [EC:1.3.99.19, RHEA:14949] +synonym: "quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.19] +synonym: "quinoline-4-carboxylic acid 2-oxidoreductase activity" RELATED [EC:1.3.99.19] +xref: EC:1.3.99.19 +xref: KEGG_REACTION:R05183 +xref: MetaCyc:1.3.99.19-RXN +xref: RHEA:14949 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047124 +name: L-erythro-3,5-diaminohexanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+)." [EC:1.4.1.11, RHEA:19633] +synonym: "L-3,5-diaminohexanoate dehydrogenase activity" RELATED [EC:1.4.1.11] +synonym: "L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.11] +xref: EC:1.4.1.11 +xref: KEGG_REACTION:R03349 +xref: MetaCyc:1.4.1.11-RXN +xref: RHEA:19633 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047125 +name: delta1-piperideine-2-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate." [EC:1.5.1.21] +synonym: "1,2-didehydropipecolate reductase activity" RELATED [EC:1.5.1.21] +synonym: "1,2-didehydropipecolic reductase activity" RELATED [EC:1.5.1.21] +synonym: "D1-piperideine-2-carboxylate reductase activity" EXACT [] +synonym: "delta 1-piperideine-2-carboxylate reductase activity" EXACT [] +synonym: "L-pipecolate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.5.1.21] +synonym: "P2C reductase activity" RELATED [EC:1.5.1.21] +xref: EC:1.5.1.21 +xref: MetaCyc:RXN-8166 +xref: RHEA:12524 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047126 +name: N5-(carboxyethyl)ornithine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate." [EC:1.5.1.24, RHEA:18661] +synonym: "5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" RELATED [EC:1.5.1.24] +synonym: "N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)" RELATED [EC:1.5.1.24] +xref: EC:1.5.1.24 +xref: KEGG_REACTION:R00666 +xref: MetaCyc:1.5.1.24-RXN +xref: RHEA:18661 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047127 +name: thiomorpholine-carboxylate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate." [EC:1.5.1.25, MetaCyc:1.5.1.25-RXN] +synonym: "ketimine reductase activity" RELATED [EC:1.5.1.25] +synonym: "ketimine-reducing enzyme" RELATED [EC:1.5.1.25] +synonym: "thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity" RELATED [EC:1.5.1.25] +xref: EC:1.5.1.25 +xref: MetaCyc:1.5.1.25-RXN +xref: Reactome:R-HSA-5693347 "CRYM reduces P2C to PPCA" +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047128 +name: 1,2-dehydroreticulinium reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH." [EC:1.5.1.27, RHEA:17569] +synonym: "(R)-reticuline:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.27] +synonym: "1,2-dehydroreticulinium ion reductase activity" RELATED [EC:1.5.1.27] +xref: EC:1.5.1.27 +xref: KEGG_REACTION:R04695 +xref: MetaCyc:1.5.1.27-RXN +xref: RHEA:17569 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047129 +name: opine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate." [EC:1.5.1.28, RHEA:21592] +synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming)" RELATED [EC:1.5.1.28] +synonym: "(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)" RELATED [EC:1.5.1.28] +xref: EC:1.5.1.28 +xref: KEGG_REACTION:R03732 +xref: MetaCyc:1.5.1.28-RXN +xref: RHEA:21592 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047130 +name: saccharopine dehydrogenase (NADP+, L-lysine-forming) activity +namespace: molecular_function +alt_id: GO:0010010 +def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH." [EC:1.5.1.8, RHEA:19373] +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.8] +synonym: "L-lysine-alpha-ketoglutarate reductase activity" RELATED [EC:1.5.1.8] +synonym: "lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)" RELATED [EC:1.5.1.8] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.8] +synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity" RELATED [EC:1.5.1.8] +xref: EC:1.5.1.8 +xref: KEGG_REACTION:R00716 +xref: MetaCyc:1.5.1.8-RXN +xref: Reactome:R-HSA-70938 "lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O" +xref: RHEA:19373 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0047131 +name: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH." [EC:1.5.1.9, RHEA:24520] +synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.9] +synonym: "aminoadipic semialdehyde synthase activity" RELATED [EC:1.5.1.9] +synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)" RELATED [EC:1.5.1.9] +synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)" RELATED [EC:1.5.1.9] +synonym: "NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming)" RELATED [EC:1.5.1.9] +synonym: "saccharopin dehydrogenase activity" RELATED [EC:1.5.1.9] +xref: EC:1.5.1.9 +xref: KEGG_REACTION:R02313 +xref: MetaCyc:1.5.1.9-RXN +xref: Reactome:R-HSA-70940 "saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+" +xref: RHEA:24520 +is_a: GO:0004753 ! saccharopine dehydrogenase activity + +[Term] +id: GO:0047132 +name: dihydrobenzophenanthridine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine." [EC:1.5.3.12, MetaCyc:1.5.3.12-RXN] +synonym: "dihydrobenzophenanthridine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.12] +xref: EC:1.5.3.12 +xref: MetaCyc:1.5.3.12-RXN +xref: RHEA:16621 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0047133 +name: dimethylamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine." [EC:1.5.8.1, MetaCyc:1.5.8.1-RXN] +synonym: "dimethylamine:electron-transferring flavoprotein oxidoreductase activity" RELATED [EC:1.5.8.1] +synonym: "DMADh activity" RELATED [EC:1.5.8.1] +xref: EC:1.5.8.1 +xref: MetaCyc:1.5.8.1-RXN +xref: RHEA:10204 +xref: UM-BBD_reactionID:r1380 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor + +[Term] +id: GO:0047134 +name: protein-disulfide reductase (NAD(P)) activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+." [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN] +synonym: "disulfide reductase activity" RELATED [EC:1.8.1.8] +synonym: "insulin-glutathione transhydrogenase activity" RELATED [EC:1.8.1.8] +synonym: "NAD(P)H:protein-disulfide oxidoreductase activity" RELATED [EC:1.8.1.8] +synonym: "protein disulfide reductase (NAD(P)H) activity" EXACT [] +synonym: "protein disulfide reductase activity" RELATED [EC:1.8.1.8] +synonym: "protein disulphide reductase activity" RELATED [EC:1.8.1.8] +synonym: "protein-disulfide reductase activity" BROAD [] +synonym: "protein-disulphide reductase activity" BROAD [] +xref: EC:1.8.1.8 +xref: MetaCyc:1.6.4.4-RXN +is_a: GO:0015035 ! protein-disulfide reductase activity +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0047135 +name: bis-gamma-glutamylcystine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH." [EC:1.8.1.13, RHEA:11980] +synonym: "bis-g-glutamylcystine reductase (NADPH) activity" EXACT [] +synonym: "Bis-gamma-glutamylcystine reductase (NADPH)" RELATED [EC:1.8.1.13] +synonym: "bis-gamma-glutamylcystine reductase (NADPH) activity" RELATED [EC:1.8.1.13] +synonym: "gamma-glutamylcysteine:NADP+ oxidoreductase activity" RELATED [EC:1.8.1.13] +synonym: "NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity" RELATED [EC:1.8.1.13] +synonym: "NADPH:bis-gamma-glutamylcysteine oxidoreductase activity" RELATED [EC:1.8.1.13] +xref: EC:1.8.1.13 +xref: KEGG_REACTION:R02742 +xref: MetaCyc:1.6.4.9-RXN +xref: RHEA:11980 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0047136 +name: 4-(dimethylamino)phenylazoxybenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH." [EC:1.7.1.11, RHEA:19789] +synonym: "4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.11] +synonym: "dimethylaminoazobenzene N-oxide reductase activity" RELATED [EC:1.7.1.11] +synonym: "N,N-dimethyl-p-aminoazobenzene oxide reductase activity" RELATED [EC:1.7.1.11] +synonym: "NADPH-dependent DMAB N-oxide reductase activity" RELATED [EC:1.7.1.11] +synonym: "NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" RELATED [EC:1.7.1.11] +synonym: "NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity" RELATED [EC:1.7.1.11] +xref: EC:1.7.1.11 +xref: KEGG_REACTION:R04303 +xref: MetaCyc:1.6.6.12-RXN +xref: RHEA:19789 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0047137 +name: N-hydroxy-2-acetamidofluorene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+." [EC:1.7.1.12, MetaCyc:1.7.1.12-RXN] +synonym: "2-acetamidofluorene:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.12] +synonym: "N-hydroxy-2-acetylaminofluorene reductase activity" RELATED [EC:1.7.1.12] +synonym: "NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" RELATED [EC:1.7.1.12] +synonym: "NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity" RELATED [EC:1.7.1.12] +xref: EC:1.7.1.12 +xref: MetaCyc:1.7.1.12-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0047138 +name: obsolete aquacobalamin reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+." [EC:1.16.1.3, MetaCyc:1.6.99.12-RXN] +comment: The term was obsoleted because it is not known to be catalyzed by any gene product. +synonym: "aquocobalamin reductase activity" RELATED [EC:1.16.1.3] +synonym: "B(12a) reductase activity" RELATED [EC:1.16.1.3] +synonym: "B12a reductase activity" RELATED [EC:1.16.1.3] +synonym: "cob(II)alamin:NAD+ oxidoreductase activity" RELATED [EC:1.16.1.3] +synonym: "NADH-linked aquacobalamin reductase activity" RELATED [EC:1.16.1.3] +synonym: "NADH2:cob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.3] +synonym: "NADH:cob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.3] +synonym: "vitamin B(12a) reductase activity" RELATED [EC:1.16.1.3] +synonym: "vitamin B12a reductase activity" RELATED [EC:1.16.1.3] +xref: EC:1.16.1.3 +xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-RXN +is_obsolete: true + +[Term] +id: GO:0047139 +name: glutathione-homocystine transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine." [EC:1.8.4.1, MetaCyc:1.8.4.1-RXN] +synonym: "glutathione:homocystine oxidoreductase activity" RELATED [EC:1.8.4.1] +xref: EC:1.8.4.1 +xref: MetaCyc:1.8.4.1-RXN +xref: RHEA:11464 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047140 +name: glutathione-CoA-glutathione transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione." [EC:1.8.4.3, MetaCyc:1.8.4.3-RXN] +synonym: "CoA:glutathione-disulfide oxidoreductase activity" RELATED [EC:1.8.4.3] +synonym: "coenzyme A:glutathione-disulfide oxidoreductase activity" RELATED [EC:1.8.4.3] +synonym: "coenzyme A:oxidized-glutathione oxidoreductase activity" RELATED [EC:1.8.4.3] +synonym: "glutathione coenzyme A-glutathione transhydrogenase activity" RELATED [EC:1.8.4.3] +synonym: "glutathione-coenzyme A glutathione disulfide transhydrogenase activity" RELATED [EC:1.8.4.3] +synonym: "glutathione:coenzyme A-glutathione transhydrogenase activity" RELATED [EC:1.8.4.3] +xref: EC:1.8.4.3 +xref: MetaCyc:1.8.4.3-RXN +xref: RHEA:13125 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047141 +name: glutathione-cystine transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine." [EC:1.8.4.4, MetaCyc:1.8.4.4-RXN] +synonym: "glutathione:cystine oxidoreductase" RELATED [EC:1.8.4.4] +synonym: "GSH-cystine transhydrogenase" RELATED [EC:1.8.4.4] +synonym: "NADPH-dependent GSH-cystine transhydrogenase" RELATED [EC:1.8.4.4] +xref: EC:1.8.4.4 +xref: MetaCyc:1.8.4.4-RXN +xref: RHEA:12613 +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047142 +name: enzyme-thiol transhydrogenase (glutathione-disulfide) activity +namespace: molecular_function +def: "Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase." [EC:1.8.4.7, MetaCyc:1.8.4.7-RXN] +synonym: "[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity" RELATED [EC:1.8.4.7] +synonym: "enzyme-thiol transhydrogenase (glutathione-disulphide) activity" EXACT [] +synonym: "enzyme-thiol transhydrogenase (oxidized-glutathione) activity" EXACT [] +synonym: "glutathione-dependent thiol:disulfide oxidoreductase activity" RELATED [EC:1.8.4.7] +synonym: "thiol:disulfide oxidoreductase activity" RELATED [EC:1.8.4.7] +synonym: "thiol:disulphide oxidoreductase activity" RELATED [EC:1.8.4.7] +synonym: "xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity" RELATED [EC:1.8.4.7] +synonym: "xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity" RELATED [EC:1.8.4.7] +xref: EC:1.8.4.7 +xref: MetaCyc:1.8.4.7-RXN +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0047143 +name: chlorate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+)." [EC:1.97.1.1, RHEA:16349] +synonym: "chlorate reductase C" RELATED [EC:1.97.1.1] +synonym: "chlorite:acceptor oxidoreductase activity" RELATED [EC:1.97.1.1] +xref: EC:1.97.1.1 +xref: KEGG_REACTION:R03575 +xref: MetaCyc:1.97.1.1-RXN +xref: RHEA:16349 +xref: UM-BBD_reactionID:r0981 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0047144 +name: 2-acylglycerol-3-phosphate O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA." [GOC:ab, RHEA:14233] +synonym: "2-acylglycerophosphate acyltransferase activity" RELATED [EC:2.3.1.52] +synonym: "acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity" RELATED [EC:2.3.1.52] +xref: EC:2.3.1.52 +xref: MetaCyc:2-ACYL2.3.1.15-RXN +xref: Reactome:R-HSA-1482533 "2-acyl LPC is acylated to PC by LPCAT" +xref: Reactome:R-HSA-1482546 "2-acyl LPG is acylated to PG by CRLS1 (IM)" +xref: Reactome:R-HSA-1482626 "2-acyl LPI is acylated to PI by MBOAT7" +xref: Reactome:R-HSA-1482635 "2-acyl LPG is acylated to PG by LPGAT" +xref: Reactome:R-HSA-1482646 "2-acyl LPE is acylated to PE by LPEAT" +xref: Reactome:R-HSA-1482691 "2-acyl LPS is acylated to PS by LPSAT" +xref: RHEA:14233 +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity + +[Term] +id: GO:0047145 +name: demethylsterigmatocystin 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.109, MetaCyc:2.1.1.109-RXN] +synonym: "demethylsterigmatocystin methyltransferase activity" RELATED [EC:2.1.1.109] +synonym: "O-methyltransferase I" RELATED [EC:2.1.1.109] +synonym: "S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity" RELATED [EC:2.1.1.109] +xref: EC:2.1.1.109 +xref: MetaCyc:2.1.1.109-RXN +xref: RHEA:11504 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047146 +name: sterigmatocystin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine." [EC:2.1.1.110, MetaCyc:2.1.1.110-RXN] +synonym: "O-methyltransferase II activity" RELATED [EC:2.1.1.110] +synonym: "S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity" RELATED [EC:2.1.1.110] +synonym: "S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity" RELATED [EC:2.1.1.110] +synonym: "sterigmatocystin 8-O-methyltransferase activity" RELATED [EC:2.1.1.110] +synonym: "sterigmatocystin methyltransferase activity" RELATED [EC:2.1.1.110] +xref: EC:2.1.1.110 +xref: MetaCyc:2.1.1.110-RXN +xref: RHEA:15561 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047147 +name: trimethylsulfonium-tetrahydrofolate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+)." [EC:2.1.1.19, RHEA:13693] +synonym: "trimethylsulfonium-tetrahydrofolate methyltransferase activity" RELATED [EC:2.1.1.19] +synonym: "trimethylsulfonium:tetrahydrofolate N-methyltransferase activity" RELATED [EC:2.1.1.19] +synonym: "trimethylsulphonium-tetrahydrofolate N-methyltransferase activity" EXACT [] +xref: EC:2.1.1.19 +xref: KEGG_REACTION:R02573 +xref: MetaCyc:2.1.1.19-RXN +xref: RHEA:13693 +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0047148 +name: methylamine-glutamate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+)." [EC:2.1.1.21, RHEA:15837] +synonym: "methylamine-glutamate methyltransferase activity" RELATED [EC:2.1.1.21] +synonym: "methylamine:L-glutamate N-methyltransferase activity" RELATED [EC:2.1.1.21] +synonym: "N-methylglutamate synthase activity" RELATED [EC:2.1.1.21] +xref: EC:2.1.1.21 +xref: KEGG_REACTION:R01586 +xref: MetaCyc:2.1.1.21-RXN +xref: RHEA:15837 +is_a: GO:0008170 ! N-methyltransferase activity + +[Term] +id: GO:0047149 +name: thetin-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+)." [EC:2.1.1.3, RHEA:22788] +synonym: "dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.3] +synonym: "dimethylthetin-homocysteine methyltransferase activity" RELATED [EC:2.1.1.3] +synonym: "thetin-homocysteine methylpherase activity" RELATED [EC:2.1.1.3] +xref: EC:2.1.1.3 +xref: KEGG_REACTION:R04153 +xref: MetaCyc:2.1.1.3-RXN +xref: RHEA:22788 +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0047150 +name: betaine-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine." [EC:2.1.1.5, RHEA:22336] +synonym: "betaine-homocysteine methyltransferase activity" RELATED [EC:2.1.1.5] +synonym: "betaine-homocysteine transmethylase activity" RELATED [EC:2.1.1.5] +synonym: "trimethylammonioacetate:L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.5] +xref: EC:2.1.1.5 +xref: KEGG_REACTION:R02821 +xref: MetaCyc:2.1.1.5-RXN +xref: Reactome:R-HSA-1614654 "BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY" +xref: RHEA:22336 +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0047151 +name: methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+." [EC:2.1.1.74, MetaCyc:2.1.1.74-RXN] +synonym: "5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity" RELATED [EC:2.1.1.74] +synonym: "5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity" RELATED [EC:2.1.1.74] +synonym: "folate-dependent ribothymidyl synthase activity" RELATED [EC:2.1.1.74] +synonym: "methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity" RELATED [EC:2.1.1.74] +synonym: "methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity" EXACT [] +xref: EC:2.1.1.74 +xref: KEGG_REACTION:R03704 +xref: MetaCyc:2.1.1.74-RXN +xref: RHEA:16873 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0047152 +name: methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity +namespace: molecular_function +alt_id: GO:1990087 +def: "Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide." [PMID:6438059, RHEA:45204] +comment: This function is the first step in the pathway of methanogenesis from methanol. +synonym: "methanol cobalamin methyltransferase activity" RELATED [EC:2.1.1.90] +synonym: "methanol-corrinoid protein Co-methyltransferase" EXACT [] +synonym: "methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity" RELATED [EC:2.1.1.90] +synonym: "methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity" RELATED [EC:2.1.1.90] +synonym: "methanol:corrinoid methyltransferase activity" EXACT [] +synonym: "methyltransferase 1" BROAD [] +synonym: "MT 1" RELATED [EC:2.1.1.90] +synonym: "MT1" RELATED [] +synonym: "MtaB" RELATED [] +xref: EC:2.1.1.90 +xref: MetaCyc:2.1.1.90-RXN +xref: RHEA:45204 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0047153 +name: deoxycytidylate 5-hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate." [EC:2.1.2.8, RHEA:11280] +synonym: "5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity" RELATED [EC:2.1.2.8] +synonym: "d-cytidine 5'-monophosphate hydroxymethylase activity" RELATED [EC:2.1.2.8] +synonym: "dCMP hydroxymethylase activity" RELATED [EC:2.1.2.8] +synonym: "deoxyCMP hydroxymethylase activity" RELATED [EC:2.1.2.8] +synonym: "deoxycytidylate hydroxymethylase activity" RELATED [EC:2.1.2.8] +synonym: "deoxycytidylate hydroxymethyltransferase activity" EXACT [] +synonym: "deoxycytidylic hydroxymethylase activity" RELATED [EC:2.1.2.8] +xref: EC:2.1.2.8 +xref: KEGG_REACTION:R01669 +xref: MetaCyc:2.1.2.8-RXN +xref: RHEA:11280 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0047154 +name: methylmalonyl-CoA carboxytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA." [EC:2.1.3.1, MetaCyc:2.1.3.1-RXN] +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate" RELATED [EC:2.1.3.1] +synonym: "(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity" RELATED [EC:2.1.3.1] +synonym: "(S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity" RELATED [EC:2.1.3.1] +synonym: "(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity" RELATED [EC:2.1.3.1] +synonym: "methylmalonyl coenzyme A carboxyltransferase activity" RELATED [EC:2.1.3.1] +synonym: "methylmalonyl-CoA carboxyltransferase activity" EXACT [] +synonym: "methylmalonyl-CoA transcarboxylase activity" RELATED [EC:2.1.3.1] +synonym: "oxalacetic transcarboxylase activity" RELATED [EC:2.1.3.1] +synonym: "transcarboxylase activity" RELATED [EC:2.1.3.1] +xref: EC:2.1.3.1 +xref: MetaCyc:2.1.3.1-RXN +xref: RHEA:20764 +xref: UM-BBD_reactionID:r0923 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0047155 +name: 3-hydroxymethylcephem carbamoyltransferase activity +namespace: molecular_function +alt_id: GO:0045447 +def: "Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem." [EC:2.1.3.7, MetaCyc:2.1.3.7-RXN] +synonym: "3'-hydroxymethylcephem-O-carbamoyltransferase activity" EXACT [] +synonym: "carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity" RELATED [EC:2.1.3.7] +xref: EC:2.1.3.7 +xref: MetaCyc:2.1.3.7-RXN +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0047156 +name: acetoin-ribose-5-phosphate transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde." [RHEA:21504] +synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthase activity" RELATED [EC:2.2.1.4] +synonym: "1-deoxy-D-altro-heptulose-7-phosphate synthetase activity" RELATED [EC:2.2.1.4] +synonym: "3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity" RELATED [EC:2.2.1.4] +synonym: "3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity" RELATED [EC:2.2.1.4] +xref: EC:2.2.1.4 +xref: KEGG_REACTION:R02345 +xref: MetaCyc:2.2.1.4-RXN +xref: RHEA:21504 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0047157 +name: myelin-proteolipid O-palmitoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA." [PMID:3818589] +synonym: "[myelin-proteolipid] O-palmitoyltransferase activity" RELATED [EC:2.3.1.100] +synonym: "acyl-protein synthase activity" BROAD [EC:2.3.1.100] +synonym: "myelin PLP acyltransferase activity" RELATED [EC:2.3.1.100] +synonym: "palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity" RELATED [EC:2.3.1.100] +xref: EC:2.3.1.100 +xref: MetaCyc:2.3.1.100-RXN +is_a: GO:0016416 ! O-palmitoyltransferase activity + +[Term] +id: GO:0047158 +name: sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose." [EC:2.3.1.103, RHEA:22664] +synonym: "1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.103] +synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity" RELATED [EC:2.3.1.103] +synonym: "hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.103] +xref: EC:2.3.1.103 +xref: KEGG_REACTION:R00063 +xref: MetaCyc:2.3.1.103-RXN +xref: RHEA:22664 +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0047159 +name: 1-alkenylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA." [EC:2.3.1.104, MetaCyc:2.3.1.104-RXN] +synonym: "acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.25] +xref: EC:2.3.1.25 +xref: MetaCyc:2.3.1.104-RXN +xref: RHEA:10344 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047160 +name: alkylglycerophosphate 2-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA." [EC:2.3.1.105, RHEA:18557] +synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity" RELATED [EC:2.3.1.105] +synonym: "alkyllyso-GP:acetyl-CoA acetyltransferase activity" RELATED [EC:2.3.1.105] +xref: EC:2.3.1.105 +xref: KEGG_REACTION:R03455 +xref: MetaCyc:2.3.1.105-RXN +xref: RHEA:18557 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047161 +name: tartronate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate." [EC:2.3.1.106, RHEA:10952] +synonym: "hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.106] +synonym: "sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.106] +synonym: "tartronate sinapoyltransferase activity" RELATED [EC:2.3.1.106] +xref: EC:2.3.1.106 +xref: KEGG_REACTION:R03965 +xref: MetaCyc:2.3.1.106-RXN +xref: RHEA:10952 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047162 +name: 17-O-deacetylvindoline O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA." [EC:2.3.1.107, RHEA:24496] +synonym: "17-O-deacetylvindoline-17-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "DAT activity" RELATED [EC:2.3.1.107] +synonym: "deacetylvindoline acetyltransferase activity" RELATED [EC:2.3.1.107] +synonym: "deacetylvindoline O-acetyltransferase activity" RELATED [EC:2.3.1.107] +xref: EC:2.3.1.107 +xref: KEGG_REACTION:R03230 +xref: MetaCyc:2.3.1.107-RXN +xref: RHEA:24496 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047163 +name: 3,4-dichloroaniline N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA." [EC:2.3.1.114, RHEA:21060] +synonym: "malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity" RELATED [EC:2.3.1.114] +xref: EC:2.3.1.114 +xref: KEGG_REACTION:R04050 +xref: MetaCyc:2.3.1.114-RXN +xref: RHEA:21060 +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047164 +name: isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA." [EC:2.3.1.115, MetaCyc:2.3.1.115-RXN] +synonym: "flavone (flavonol) 7-O-glycoside malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity" RELATED [EC:2.3.1.115] +synonym: "MAT-7" RELATED [EC:2.3.1.115] +xref: EC:2.3.1.115 +xref: MetaCyc:2.3.1.115-RXN +xref: RHEA:15581 +is_a: GO:0050736 ! O-malonyltransferase activity + +[Term] +id: GO:0047165 +name: flavonol-3-O-beta-glucoside O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA." [EC:2.3.1.116, MetaCyc:2.3.1.116-RXN] +synonym: "flavonol 3-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.116] +synonym: "malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity" RELATED [EC:2.3.1.116] +synonym: "malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity" RELATED [EC:2.3.1.116] +synonym: "MAT-3" RELATED [EC:2.3.1.116] +xref: EC:2.3.1.116 +xref: MetaCyc:2.3.1.116-RXN +xref: RHEA:20085 +is_a: GO:0050736 ! O-malonyltransferase activity + +[Term] +id: GO:0047166 +name: 1-alkenylglycerophosphoethanolamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA." [EC:2.3.1.121, MetaCyc:2.3.1.121-RXN] +synonym: "acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity" RELATED [EC:2.3.1.121] +xref: EC:2.3.1.121 +xref: MetaCyc:2.3.1.121-RXN +xref: RHEA:16245 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047167 +name: 1-alkyl-2-acetylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA." [EC:2.3.1.125, MetaCyc:2.3.1.125-RXN] +synonym: "1-hexadecyl-2-acetylglycerol acyltransferase activity" RELATED [EC:2.3.1.125] +synonym: "acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity" RELATED [EC:2.3.1.125] +xref: EC:2.3.1.125 +xref: MetaCyc:2.3.1.125-RXN +xref: RHEA:21996 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047168 +name: isocitrate O-dihydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA." [EC:2.3.1.126, RHEA:20756] +synonym: "caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.126] +xref: EC:2.3.1.126 +xref: KEGG_REACTION:R01946 +xref: MetaCyc:2.3.1.126-RXN +xref: RHEA:20756 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047169 +name: galactarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA." [EC:2.3.1.130, RHEA:12997] +synonym: "feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.130] +synonym: "galacturate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.130] +xref: EC:2.3.1.130 +xref: KEGG_REACTION:R03727 +xref: MetaCyc:2.3.1.130-RXN +xref: RHEA:12997 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047170 +name: glucarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA." [EC:2.3.1.131, RHEA:23308] +synonym: "sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.131] +xref: EC:2.3.1.131 +xref: KEGG_REACTION:R02899 +xref: MetaCyc:2.3.1.131-RXN +xref: RHEA:23308 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047171 +name: glucarolactone O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA." [EC:2.3.1.132, MetaCyc:2.3.1.132-RXN] +synonym: "sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.132] +xref: EC:2.3.1.132 +xref: MetaCyc:2.3.1.132-RXN +xref: RHEA:14261 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047172 +name: shikimate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA." [EC:2.3.1.133, MetaCyc:2.3.1.133-RXN] +synonym: "4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.133] +synonym: "shikimate hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.133] +xref: EC:2.3.1.133 +xref: MetaCyc:2.3.1.133-RXN +xref: RHEA:12124 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047173 +name: phosphatidylcholine-retinol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine." [EC:2.3.1.135, MetaCyc:2.3.1.135-RXN] +synonym: "lecithin--retinol acyltransferase activity" RELATED [EC:2.3.1.135] +synonym: "phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity" RELATED [EC:2.3.1.135] +synonym: "phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity" RELATED [EC:2.3.1.135] +xref: EC:2.3.1.135 +xref: MetaCyc:2.3.1.135-RXN +xref: Reactome:R-HSA-975608 "LRAT esterifies RBP2:atROL and FACYLs to atREs" +xref: RHEA:17469 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047174 +name: putrescine N-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+)." [EC:2.3.1.138, RHEA:12436] +synonym: "caffeoyl-CoA putrescine N-caffeoyl transferase activity" RELATED [EC:2.3.1.138] +synonym: "caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.138] +synonym: "hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.138] +synonym: "PHT" RELATED [EC:2.3.1.138] +synonym: "putrescine hydroxycinnamoyl transferase activity" RELATED [EC:2.3.1.138] +synonym: "putrescine hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.138] +xref: EC:2.3.1.138 +xref: KEGG_REACTION:R01944 +xref: MetaCyc:2.3.1.138-RXN +xref: RHEA:12436 +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0050734 ! hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047175 +name: galactosylacylglycerol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]." [EC:2.3.1.141, MetaCyc:2.3.1.141-RXN] +synonym: "acyl-ACP:lyso-MGDG acyltransferase activity" RELATED [EC:2.3.1.141] +synonym: "acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity" RELATED [EC:2.3.1.141] +synonym: "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity" RELATED [EC:2.3.1.141] +xref: EC:2.3.1.141 +xref: MetaCyc:2.3.1.141-RXN +xref: RHEA:17057 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047176 +name: beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.143, RHEA:19109] +synonym: "1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143] +synonym: "beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity" RELATED [EC:2.3.1.143] +synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143] +synonym: "beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity" RELATED [EC:2.3.1.143] +xref: EC:2.3.1.143 +xref: KEGG_REACTION:R04498 +xref: MetaCyc:2.3.1.143-RXN +xref: RHEA:19109 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047177 +name: glycerophospholipid arachidonoyl-transferase (CoA-independent) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.147, MetaCyc:2.3.1.147-RXN] +synonym: "1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" RELATED [EC:2.3.1.147] +synonym: "1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)" RELATED [EC:2.3.1.147] +xref: EC:2.3.1.147 +xref: MetaCyc:2.3.1.147-RXN +xref: RHEA:15409 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047178 +name: glycerophospholipid acyltransferase (CoA-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine." [EC:2.3.1.148, MetaCyc:2.3.1.148-RXN] +synonym: "1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)" RELATED [EC:2.3.1.148] +xref: EC:2.3.1.148 +xref: MetaCyc:2.3.1.148-RXN +xref: RHEA:20972 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047179 +name: platelet-activating factor acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid." [EC:2.3.1.149, MetaCyc:2.3.1.149-RXN] +synonym: "1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity" RELATED [EC:2.3.1.149] +synonym: "PAF acetyltransferase activity" EXACT [] +xref: EC:2.3.1.149 +xref: MetaCyc:2.3.1.149-RXN +xref: RHEA:11048 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0047180 +name: salutaridinol 7-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA." [EC:2.3.1.150, RHEA:22856] +synonym: "acetyl-CoA:salutaridinol 7-O-acetyltransferase activity" RELATED [EC:2.3.1.150] +xref: EC:2.3.1.150 +xref: KEGG_REACTION:R04723 +xref: MetaCyc:2.3.1.150-RXN +xref: RHEA:22856 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047181 +name: tetrahydroxybenzophenone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A." [EC:2.3.1.151, MetaCyc:2.3.1.151-RXN] +synonym: "malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity" RELATED [EC:2.3.1.151] +xref: EC:2.3.1.151 +xref: MetaCyc:2.3.1.151-RXN +xref: RHEA:19305 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047182 +name: alcohol O-cinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate." [EC:2.3.1.152, MetaCyc:2.3.1.152-RXN] +synonym: "1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity" RELATED [EC:2.3.1.152] +xref: EC:2.3.1.152 +xref: MetaCyc:2.3.1.152-RXN +xref: RHEA:23524 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047183 +name: anthocyanin 5-aromatic acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA." [EC:2.3.1.153, MetaCyc:2.3.1.153-RXN] +synonym: "hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity" RELATED [EC:2.3.1.153] +xref: EC:2.3.1.153 +xref: MetaCyc:RXN-7945 +xref: RHEA:15661 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047184 +name: 1-acylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +alt_id: GO:0000507 +def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA." [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN] +synonym: "1-acyl-sn-glycero-3-phosphocholine acyltransferase activity" RELATED [EC:2.3.1.23] +synonym: "acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity" RELATED [EC:2.3.1.23] +synonym: "acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity" RELATED [EC:2.3.1.23] +synonym: "acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.23] +synonym: "lysolecithin acyltransferase activity" RELATED [EC:2.3.1.23] +synonym: "lysophosphatide acyltransferase activity" RELATED [EC:2.3.1.23] +synonym: "lysophosphatidylcholine acyltransferase activity" RELATED [EC:2.3.1.23] +xref: EC:2.3.1.23 +xref: MetaCyc:2.3.1.23-RXN +xref: Reactome:R-HSA-1482794 "CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible)" +xref: RHEA:12937 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047185 +name: N-acetylneuraminate 4-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA." [EC:2.3.1.44, RHEA:18305] +synonym: "acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity" RELATED [EC:2.3.1.44] +synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.44] +xref: EC:2.3.1.44 +xref: KEGG_REACTION:R01806 +xref: MetaCyc:2.3.1.44-RXN +xref: RHEA:18305 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047186 +name: N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA." [EC:2.3.1.45, MetaCyc:2.3.1.45-RXN] +synonym: "acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "glycoprotein 7(9)-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "N-acetylneuraminate 7(8)-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "N-acetylneuraminate 7,8-O-acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "N-acetylneuraminate O7-(or O9-)acetyltransferase activity" RELATED [EC:2.3.1.45] +synonym: "sialate O-acetyltransferase" BROAD [EC:2.3.1.45] +xref: EC:2.3.1.45 +xref: MetaCyc:2.3.1.45-RXN +xref: RHEA:20808 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047187 +name: deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate." [EC:2.3.1.49, MetaCyc:2.3.1.49-RXN] +synonym: "deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity" RELATED [EC:2.3.1.49] +synonym: "deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity" RELATED [EC:2.3.1.49] +synonym: "S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity" RELATED [EC:2.3.1.49] +synonym: "S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity" RELATED [EC:2.3.1.49] +xref: EC:2.3.1.49 +xref: MetaCyc:2.3.1.49-RXN +xref: RHEA:20393 +is_a: GO:0016418 ! S-acetyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0047188 +name: aromatic-hydroxylamine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl." [EC:2.3.1.56, MetaCyc:2.3.1.56-RXN] +synonym: "aromatic hydroxylamine acetyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "arylhydroxamate acyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "arylhydroxamic acid N,O-acetyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "arylhydroxamic acyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "N,O-acetyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity" RELATED [EC:2.3.1.56] +synonym: "N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity" RELATED [EC:2.3.1.56] +xref: EC:2.3.1.56 +xref: MetaCyc:2.3.1.56-RXN +xref: RHEA:20325 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047189 +name: 2,3-diaminopropionate N-oxalyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA." [EC:2.3.1.58, RHEA:13465] +synonym: "ODAP synthase activity" RELATED [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity" RELATED [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity" RELATED [EC:2.3.1.58] +synonym: "oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity" RELATED [EC:2.3.1.58] +synonym: "oxalyldiaminopropionate synthase activity" RELATED [EC:2.3.1.58] +synonym: "oxalyldiaminopropionic synthase activity" RELATED [EC:2.3.1.58] +xref: EC:2.3.1.58 +xref: KEGG_REACTION:R04211 +xref: MetaCyc:2.3.1.58-RXN +xref: RHEA:13465 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047190 +name: 2-acylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA." [RHEA:10332] +synonym: "2-acylglycerol-3-phosphorylcholine acyltransferase activity" RELATED [EC:2.3.1.62] +synonym: "2-acylglycerophosphocholine acyltransferase activity" RELATED [EC:2.3.1.62] +synonym: "acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.62] +xref: EC:2.3.1.62 +xref: KEGG_REACTION:R01319 +xref: MetaCyc:2.3.1.62-RXN +xref: RHEA:10332 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047191 +name: 1-alkylglycerophosphocholine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.63, MetaCyc:2.3.1.63-RXN] +synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity" RELATED [EC:2.3.1.63] +xref: EC:2.3.1.63 +xref: MetaCyc:2.3.1.63-RXN +xref: RHEA:23992 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047192 +name: 1-alkylglycerophosphocholine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA." [EC:2.3.1.67, MetaCyc:2.3.1.67-RXN] +synonym: "1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "1-alkyl-2-lysolecithin acetyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "acetyl-CoA:lyso-PAF acetyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity" RELATED [EC:2.3.1.67] +synonym: "blood platelet-activating factor acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-GPC:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-platelet activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "lysopaf:acetyl CoA acetyltransferase activity" BROAD [EC:2.3.1.67] +synonym: "platelet-activating factor acylhydrolase activity" BROAD [EC:2.3.1.67] +synonym: "platelet-activating factor-synthesizing enzyme activity" BROAD [EC:2.3.1.67] +xref: EC:2.3.1.67 +xref: MetaCyc:2.3.1.67-RXN +xref: RHEA:18461 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047193 +name: obsolete CDP-acylglycerol O-arachidonoyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: CDP-acylglycerol + arachidonyl-CoA = CDP-diacylglycerol + CoA." [EC:2.3.1.70, MetaCyc:2.3.1.70-RXN] +comment: This term was made obsolete because the evidence for the existence of this reaction was retracted. Please see PMID:6885763 for more information. +synonym: "arachidonoyl-CoA:CDP-acylglycerol O-arachidonoyltransferase activity" RELATED [EC:2.3.1.70] +synonym: "arachidonyl-CoA:CDP-acylglycerol O-arachidonyltransferase activity" RELATED [EC:2.3.1.70] +synonym: "CDP-acylglycerol O-arachidonoyltransferase activity" EXACT [] +synonym: "CDP-acylglycerol O-arachidonyltransferase activity" EXACT [] +synonym: "CDPacylglycerol O-arachidonyltransferase activity" RELATED [EC:2.3.1.70] +xref: MetaCyc:2.3.1.70-RXN +is_obsolete: true + +[Term] +id: GO:0047194 +name: indoleacetylglucose-inositol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose." [EC:2.3.1.72, RHEA:21180] +synonym: "1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity" RELATED [EC:2.3.1.72] +synonym: "1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity" RELATED [EC:2.3.1.72] +synonym: "indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity" RELATED [EC:2.3.1.72] +xref: EC:2.3.1.72 +xref: KEGG_REACTION:R04333 +xref: MetaCyc:2.3.1.72-RXN +xref: RHEA:21180 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047195 +name: diacylglycerol-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol." [EC:2.3.1.73, MetaCyc:2.3.1.73-RXN] +synonym: "1,2-diacyl-sn-glycerol:sterol acyl transferase activity" RELATED [EC:2.3.1.73] +synonym: "1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity" RELATED [EC:2.3.1.73] +xref: EC:2.3.1.73 +xref: MetaCyc:2.3.1.73-RXN +xref: RHEA:13301 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047196 +name: long-chain-alcohol O-fatty-acyltransferase activity +namespace: molecular_function +alt_id: GO:0103095 +def: "Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA." [EC:2.3.1.75, MetaCyc:2.3.1.75-RXN] +synonym: "acyl-CoA:long-chain-alcohol O-acyltransferase activity" RELATED [EC:2.3.1.75] +synonym: "wax ester synthase activity" EXACT [] +synonym: "wax synthase activity" RELATED [EC:2.3.1.75] +synonym: "wax-ester synthase activity" RELATED [EC:2.3.1.75] +xref: EC:2.3.1.75 +xref: MetaCyc:2.3.1.75-RXN +xref: MetaCyc:RXNQT-4193 +xref: Reactome:R-HSA-5696424 "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters" +xref: Reactome:R-HSA-8848582 "AWAT2 transfers PALM from PALM-CoA to HXOL, forming palmityl palmitate ester" +xref: RHEA:38443 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047197 +name: triglyceride-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol." [EC:2.3.1.77, MetaCyc:2.3.1.77-RXN] +synonym: "triacylglycerol-sterol O-acyltransferase activity" EXACT [] +synonym: "triacylglycerol:3beta-hydroxysterol O-acyltransferase activity" RELATED [EC:2.3.1.77] +synonym: "triacylglycerol:sterol acyltransferase activity" RELATED [EC:2.3.1.77] +xref: EC:2.3.1.77 +xref: MetaCyc:2.3.1.77-RXN +xref: RHEA:16897 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047198 +name: cysteine-S-conjugate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+)." [EC:2.3.1.80, RHEA:19213] +synonym: "acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity" RELATED [EC:2.3.1.80] +xref: EC:2.3.1.80 +xref: KEGG_REACTION:R04950 +xref: MetaCyc:2.3.1.80-RXN +xref: Reactome:R-HSA-5433066 "Unknown NAT transfers COCH3 to AFXBO-C, AFNBO-C" +xref: RHEA:19213 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047199 +name: phosphatidylcholine-dolichol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol." [EC:2.3.1.83, RHEA:19285] +synonym: "3-sn-phosphatidylcholine:dolichol O-acyltransferase activity" RELATED [EC:2.3.1.83] +xref: EC:2.3.1.83 +xref: KEGG_REACTION:R04227 +xref: MetaCyc:2.3.1.83-RXN +xref: RHEA:19285 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047200 +name: tetrahydrodipicolinate N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA." [EC:2.3.1.89, RHEA:13085] +synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity" RELATED [EC:2.3.1.89] +synonym: "acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity" RELATED [EC:2.3.1.89] +synonym: "acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity" RELATED [EC:2.3.1.89] +synonym: "tetrahydrodipicolinate acetylase activity" RELATED [EC:2.3.1.89] +synonym: "tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity" RELATED [EC:2.3.1.89] +xref: EC:2.3.1.89 +xref: KEGG_REACTION:R04364 +xref: MetaCyc:2.3.1.89-RXN +xref: RHEA:13085 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047201 +name: beta-glucogallin O-galloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." [EC:2.3.1.90, RHEA:11416] +synonym: "1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity" RELATED [EC:2.3.1.90] +xref: EC:2.3.1.90 +xref: KEGG_REACTION:R00049 +xref: MetaCyc:2.3.1.90-RXN +xref: RHEA:11416 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047202 +name: sinapoylglucose-choline O-sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose." [EC:2.3.1.91, RHEA:12024] +synonym: "1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity" RELATED [EC:2.3.1.91] +synonym: "sinapine synthase activity" RELATED [EC:2.3.1.91] +xref: EC:2.3.1.91 +xref: KEGG_REACTION:R03075 +xref: MetaCyc:2.3.1.91-RXN +xref: RHEA:12024 +is_a: GO:0016753 ! O-sinapoyltransferase activity + +[Term] +id: GO:0047203 +name: 13-hydroxylupinine O-tigloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA." [EC:2.3.1.93, RHEA:12360] +synonym: "(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity" RELATED [EC:2.3.1.93] +synonym: "13-hydroxylupanine acyltransferase activity" RELATED [EC:2.3.1.93] +synonym: "tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity" RELATED [EC:2.3.1.93] +xref: EC:2.3.1.93 +xref: KEGG_REACTION:R04205 +xref: MetaCyc:2.3.1.93-RXN +xref: RHEA:12360 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047204 +name: chlorogenate-glucarate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate." [EC:2.3.1.98, RHEA:23204] +synonym: "chlorogenate:glucarate caffeoyltransferase activity" RELATED [EC:2.3.1.98] +synonym: "chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.98] +synonym: "chlorogenic acid:glucaric acid O-caffeoyltransferase activity" RELATED [EC:2.3.1.98] +xref: EC:2.3.1.98 +xref: KEGG_REACTION:R02998 +xref: MetaCyc:2.3.1.98-RXN +xref: RHEA:23204 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047205 +name: quinate O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA." [EC:2.3.1.99, MetaCyc:2.3.1.99-RXN] +synonym: "feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.99] +synonym: "hydroxycinnamoyl coenzyme A-quinate transferase activity" RELATED [EC:2.3.1.99] +xref: EC:2.3.1.99 +xref: MetaCyc:2.3.1.99-RXN +xref: RHEA:15021 +is_a: GO:0050737 ! O-hydroxycinnamoyltransferase activity + +[Term] +id: GO:0047206 +name: UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA." [EC:2.3.2.10, MetaCyc:2.3.2.10-RXN] +synonym: "alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity" RELATED [EC:2.3.2.10] +synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity" RELATED [EC:2.3.2.10] +synonym: "L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity" RELATED [EC:2.3.2.10] +synonym: "UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" RELATED [EC:2.3.2.10] +synonym: "UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity" RELATED [EC:2.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity" RELATED [EC:2.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity" RELATED [EC:2.3.2.10] +xref: EC:2.3.2.10 +xref: MetaCyc:2.3.2.10-RXN +xref: RHEA:12432 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0047207 +name: 1,2-beta-fructan 1F-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1)." [EC:2.4.1.100, MetaCyc:2.4.1.100-RXN] +synonym: "1,2-beta-D-fructan 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan 1F-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "1,2-beta-fructan 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "2,1-fructan:2,1-fructan 1-fructosyltransferase activity" RELATED [EC:2.4.1.100] +synonym: "FFT activity" RELATED [EC:2.4.1.100] +synonym: "fructan:fructan fructosyl transferase activity" RELATED [EC:2.4.1.100] +xref: EC:2.4.1.100 +xref: MetaCyc:2.4.1.100-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0047208 +name: o-dihydroxycoumarin 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP." [EC:2.4.1.104, RHEA:14325] +synonym: "UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.104] +synonym: "UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity" RELATED [EC:2.4.1.104] +synonym: "UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.104] +synonym: "uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.104] +xref: EC:2.4.1.104 +xref: KEGG_REACTION:R03548 +xref: MetaCyc:2.4.1.104-RXN +xref: RHEA:14325 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047209 +name: coniferyl-alcohol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP." [EC:2.4.1.111, MetaCyc:2.4.1.111-RXN] +synonym: "UDP-glucose coniferyl alcohol glucosyltransferase activity" RELATED [EC:2.4.1.111] +synonym: "UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.111] +synonym: "UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.111] +synonym: "uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity" RELATED [EC:2.4.1.111] +xref: EC:2.4.1.111 +xref: MetaCyc:2.4.1.111-RXN +xref: RHEA:23944 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047211 +name: alpha-1,4-glucan-protein synthase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP." [EC:2.4.1.113, MetaCyc:2.4.1.113-RXN] +synonym: "1,4alpha-glucan-protein synthase (ADP-forming) activity" EXACT [] +synonym: "adenosine diphosphoglucose-protein glucosyltransferase activity" RELATED [EC:2.4.1.113] +synonym: "ADP-glucose:protein 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.113] +synonym: "ADPglucose:protein 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.113] +synonym: "ADPglucose:protein glucosyltransferase activity" RELATED [EC:2.4.1.113] +xref: EC:2.4.1.113 +xref: MetaCyc:2.4.1.113-RXN +is_a: GO:0016758 ! hexosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0047212 +name: 2-coumarate O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP." [EC:2.4.1.114, RHEA:10236] +synonym: "UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.114] +synonym: "UDPG:o-coumaric acid O-glucosyltransferase activity" RELATED [EC:2.4.1.114] +synonym: "UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.114] +synonym: "uridine diphosphoglucose-o-coumarate glucosyltransferase activity" RELATED [EC:2.4.1.114] +xref: EC:2.4.1.114 +xref: KEGG_REACTION:R03710 +xref: MetaCyc:2.4.1.114-RXN +xref: RHEA:10236 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047213 +name: anthocyanidin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP." [EC:2.4.1.115, MetaCyc:2.4.1.115-RXN] +synonym: "3-GT activity" RELATED [EC:2.4.1.115] +synonym: "UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.115] +synonym: "UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.115] +synonym: "UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115] +synonym: "UDP-glucose:cyanidin-3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115] +synonym: "uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.115] +xref: EC:2.4.1.115 +xref: MetaCyc:2.4.1.115-RXN +xref: RHEA:20093 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047214 +name: cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP." [EC:2.4.1.116, MetaCyc:2.4.1.116-RXN] +synonym: "cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity" RELATED [EC:2.4.1.116] +synonym: "UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.116] +synonym: "UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.116] +synonym: "uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity" RELATED [EC:2.4.1.116] +xref: EC:2.4.1.116 +xref: MetaCyc:2.4.1.116-RXN +xref: RHEA:12144 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047215 +name: indole-3-acetate beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP." [EC:2.4.1.121, RHEA:14921] +synonym: "IAA-Glu synthetase activity" RELATED [EC:2.4.1.121] +synonym: "IAA-glucose synthase activity" RELATED [EC:2.4.1.121] +synonym: "IAGlu synthase activity" RELATED [EC:2.4.1.121] +synonym: "indol-3-ylacetylglucose synthase activity" RELATED [EC:2.4.1.121] +synonym: "UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.121] +synonym: "UDP-glucose:auxin glucosyltransferase activity" BROAD [] +synonym: "UDP-glucose:indol-3-acetic acid glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:indol-3-ylacetate glucosyl-transferase activity" RELATED [EC:2.4.1.121] +synonym: "UDP-glucose:indol-3-ylacetate glucosyltransferase activity" RELATED [EC:2.4.1.121] +synonym: "UDPG-indol-3-ylacetyl glucosyl transferase activity" RELATED [EC:2.4.1.121] +synonym: "UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.121] +synonym: "uridine diphosphoglucose-indoleacetate glucosyltransferase activity" RELATED [EC:2.4.1.121] +xref: EC:2.4.1.121 +xref: KEGG_REACTION:R03094 +xref: MetaCyc:2.4.1.121-RXN +xref: RHEA:14921 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047216 +name: inositol 3-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP." [EC:2.4.1.123, MetaCyc:2.4.1.123-RXN] +synonym: "galactinol synthase activity" RELATED [EC:2.4.1.123] +synonym: "inositol 1-alpha-galactosyltransferase activity" EXACT [] +synonym: "UDP-D-galactose:inositol galactosyltransferase activity" RELATED [EC:2.4.1.123] +synonym: "UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123] +synonym: "UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123] +synonym: "UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.123] +synonym: "uridine diphosphogalactose-inositol galactosyltransferase activity" RELATED [EC:2.4.1.123] +xref: EC:2.4.1.123 +xref: MetaCyc:2.4.1.123-RXN +xref: RHEA:12464 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047217 +name: sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose." [EC:2.4.1.125, MetaCyc:2.4.1.125-RXN] +synonym: "GTF-S" RELATED [EC:2.4.1.125] +synonym: "sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase" BROAD [EC:2.4.1.125] +synonym: "sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.125] +synonym: "sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity" RELATED [EC:2.4.1.125] +synonym: "water-soluble-glucan synthase activity" RELATED [EC:2.4.1.125] +xref: EC:2.4.1.125 +xref: MetaCyc:2.4.1.125-RXN +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0047218 +name: hydroxycinnamate 4-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP." [EC:2.4.1.126, MetaCyc:2.4.1.126-RXN] +synonym: "hydroxycinnamoyl glucosyltransferase activity" RELATED [EC:2.4.1.126] +synonym: "UDP-glucose-hydroxycinnamate glucosyltransferase activity" RELATED [EC:2.4.1.126] +synonym: "UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.126] +synonym: "UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.126] +synonym: "uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity" RELATED [EC:2.4.1.126] +xref: EC:2.4.1.126 +xref: MetaCyc:2.4.1.126-RXN +xref: RHEA:21636 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047219 +name: monoterpenol beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.127, RHEA:11520] +synonym: "UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.127] +synonym: "UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.127] +synonym: "UDPglucose:monoterpenol glucosyltransferase activity" RELATED [EC:2.4.1.127] +synonym: "uridine diphosphoglucose-monoterpenol glucosyltransferase activity" RELATED [EC:2.4.1.127] +xref: EC:2.4.1.127 +xref: KEGG_REACTION:R02179 +xref: MetaCyc:2.4.1.127-RXN +xref: RHEA:11520 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047220 +name: galactosylxylosylprotein 3-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP." [EC:2.4.1.134, MetaCyc:2.4.1.134-RXN] +synonym: "galactosyltransferase II activity" RELATED [EC:2.4.1.134] +synonym: "UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.134] +synonym: "UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.134] +synonym: "uridine diphosphogalactose-galactosylxylose galactosyltransferase activity" RELATED [EC:2.4.1.134] +xref: EC:2.4.1.134 +xref: MetaCyc:2.4.1.134-RXN +xref: Reactome:R-HSA-1889978 "B3GALT6 transfers Gal to the tetrasaccharide linker" +xref: Reactome:R-HSA-4420365 "Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker" +xref: RHEA:11780 +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047221 +name: sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.137, RHEA:14285] +synonym: "floridoside phosphate synthase activity" RELATED [EC:2.4.1.137] +synonym: "floridoside phosphate synthetase activity" RELATED [EC:2.4.1.137] +synonym: "floridoside-phosphate synthase activity" RELATED [EC:2.4.1.137] +synonym: "FPS" RELATED [EC:2.4.1.137] +synonym: "UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity" RELATED [EC:2.4.1.137] +synonym: "UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.137] +synonym: "UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity" RELATED [EC:2.4.1.137] +synonym: "UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.137] +xref: EC:2.4.1.137 +xref: KEGG_REACTION:R00853 +xref: MetaCyc:2.4.1.137-RXN +xref: RHEA:14285 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047222 +name: mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP." [EC:2.4.1.138, MetaCyc:2.4.1.138-RXN] +synonym: "alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.138] +synonym: "UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.138] +synonym: "uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity" RELATED [EC:2.4.1.138] +xref: EC:2.4.1.138 +xref: MetaCyc:2.4.1.138-RXN +xref: RHEA:13705 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047223 +name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.146, MetaCyc:2.4.1.146-RXN] +synonym: "elongation 3-beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] +synonym: "elongation 3beta-GalNAc-transferase activity" RELATED [EC:2.4.1.146] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.146] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.146] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)" RELATED [EC:2.4.1.146] +xref: EC:2.4.1.146 +xref: MetaCyc:2.4.1.146-RXN +xref: Reactome:R-HSA-5617037 "POMGNT1 transfers GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" +xref: Reactome:R-HSA-5617096 "Defective POMGNT1 does not transfer GlcNAc from UDP-GlcNAc to Man-O-Ser-DAG1" +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047224 +name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.147, MetaCyc:2.4.1.147-RXN] +synonym: "core 3-beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] +synonym: "core 3beta-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] +synonym: "mucin core 3 beta3-GlcNAc-transferase activity" RELATED [EC:2.4.1.147] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" RELATED [EC:2.4.1.147] +synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.147] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.147] +xref: EC:2.4.1.147 +xref: MetaCyc:2.4.1.147-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047225 +name: acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP." [EC:2.4.1.148, MetaCyc:2.4.1.148-RXN] +synonym: "core 4 beta6-GalNAc-transferase activity" RELATED [EC:2.4.1.148] +synonym: "core 6-beta-GalNAc-transferase B activity" RELATED [EC:2.4.1.148] +synonym: "core 6beta-GalNAc-transferase B" RELATED [EC:2.4.1.148] +synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" RELATED [EC:2.4.1.148] +synonym: "UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.148] +synonym: "uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B" RELATED [EC:2.4.1.148] +xref: EC:2.4.1.148 +xref: MetaCyc:2.4.1.148-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047227 +name: indolylacetyl-myo-inositol galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP." [EC:2.4.1.156, RHEA:21148] +synonym: "indol-3-ylacetyl-myo-inositol galactoside synthase activity" RELATED [EC:2.4.1.156] +synonym: "UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity" RELATED [EC:2.4.1.156] +synonym: "UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity" RELATED [EC:2.4.1.156] +synonym: "uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity" RELATED [EC:2.4.1.156] +xref: EC:2.4.1.156 +xref: KEGG_REACTION:R04334 +xref: MetaCyc:2.4.1.156-RXN +xref: RHEA:21148 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047228 +name: 1,2-diacylglycerol 3-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP." [EC:2.4.1.157, MetaCyc:2.4.1.157-RXN] +synonym: "UDP-glucose-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.157] +synonym: "UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" RELATED [EC:2.4.1.157] +synonym: "UDP-glucose:1,2-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.157] +synonym: "UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity" RELATED [EC:2.4.1.157] +synonym: "UDPglucose:diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.157] +synonym: "uridine diphosphoglucose-diacylglycerol glucosyltransferase activity" RELATED [EC:2.4.1.157] +xref: EC:2.4.1.157 +xref: MetaCyc:2.4.1.157-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047229 +name: 13-hydroxydocosanoate 13-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP." [EC:2.4.1.158, MetaCyc:2.4.1.158-RXN] +synonym: "13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity" RELATED [EC:2.4.1.158] +synonym: "UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity" RELATED [EC:2.4.1.158] +synonym: "UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.158] +synonym: "UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity" RELATED [EC:2.4.1.158] +synonym: "UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.158] +synonym: "uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity" RELATED [EC:2.4.1.158] +xref: EC:2.4.1.158 +xref: MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN +xref: RHEA:22316 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047230 +name: flavonol-3-O-glucoside L-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP." [EC:2.4.1.159, MetaCyc:2.4.1.159-RXN] +synonym: "UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity" RELATED [EC:2.4.1.159] +synonym: "UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity" RELATED [EC:2.4.1.159] +synonym: "uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity" RELATED [EC:2.4.1.159] +xref: EC:2.4.1.159 +xref: MetaCyc:2.4.1.159-RXN +xref: RHEA:22528 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047231 +name: pyridoxine 5'-O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP." [EC:2.4.1.160, RHEA:20177] +synonym: "UDP-glucose-pyridoxine glucosyltransferase activity" RELATED [EC:2.4.1.160] +synonym: "UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.160] +synonym: "UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity" RELATED [EC:2.4.1.160] +synonym: "UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.160] +synonym: "uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity" RELATED [EC:2.4.1.160] +xref: EC:2.4.1.160 +xref: KEGG_REACTION:R01912 +xref: MetaCyc:2.4.1.160-RXN +xref: RHEA:20177 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047232 +name: galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP." [EC:2.4.1.164, MetaCyc:2.4.1.164-RXN] +synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.164] +synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.164] +xref: EC:2.4.1.164 +xref: MetaCyc:2.4.1.164-RXN +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047233 +name: N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.165, MetaCyc:2.4.1.165-RXN] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.165] +synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.165] +xref: EC:2.4.1.165 +xref: MetaCyc:2.4.1.165-RXN +xref: RHEA:13569 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047234 +name: raffinose-raffinose alpha-galactotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose." [EC:2.4.1.166, MetaCyc:2.4.1.166-RXN] +synonym: "raffinose (raffinose donor) galactosyltransferase activity" RELATED [EC:2.4.1.166] +synonym: "raffinose-raffinose a-galactosyltransferase activity" EXACT [] +synonym: "raffinose-raffinose alpha-galactosyltransferase activity" EXACT [] +synonym: "raffinose:raffinose alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.166] +synonym: "raffinose:raffinose alpha-galactosyltransferase activity" RELATED [EC:2.4.1.166] +xref: EC:2.4.1.166 +xref: MetaCyc:2.4.1.166-RXN +xref: RHEA:14125 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047235 +name: sucrose 6F-alpha-galactotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP." [EC:2.4.1.167, MetaCyc:2.4.1.167-RXN] +synonym: "sucrose 6(F)-alpha-galactosyltransferase activity" EXACT [] +synonym: "sucrose 6F-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167] +synonym: "UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.167] +synonym: "UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.167] +synonym: "UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167] +synonym: "uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity" RELATED [EC:2.4.1.167] +xref: EC:2.4.1.167 +xref: MetaCyc:2.4.1.167-RXN +xref: RHEA:10088 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047236 +name: methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP." [EC:2.4.1.171, MetaCyc:2.4.1.171-RXN] +synonym: "cycasin synthase activity" RELATED [EC:2.4.1.171] +synonym: "methyl-ONN-azoxymethanol glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.171] +synonym: "UDPglucose-methylazoxymethanol glucosyltransferase activity" RELATED [EC:2.4.1.171] +synonym: "uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity" RELATED [EC:2.4.1.171] +xref: EC:2.4.1.171 +xref: MetaCyc:2.4.1.171-RXN +xref: RHEA:20205 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047237 +name: glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP." [EC:2.4.1.174, MetaCyc:2.4.1.174-RXN] +synonym: "glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "N-acetylgalactosaminyltransferase I activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.174] +synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I" RELATED [EC:2.4.1.174] +synonym: "uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity" RELATED [EC:2.4.1.174] +xref: EC:2.4.1.174 +xref: MetaCyc:2.4.1.174-RXN +xref: RHEA:23464 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047238 +name: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP." [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN] +synonym: "chondroitin synthase activity" RELATED [EC:2.4.1.175] +synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "N-acetylgalactosaminyltransferase II activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.175] +synonym: "UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.175] +synonym: "uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity" RELATED [EC:2.4.1.175] +xref: EC:2.4.1.175 +xref: MetaCyc:2.4.1.175-RXN +xref: Reactome:R-HSA-1971482 "The addition of GalNAc to the terminal glucuronate residue forms chondroitin" +xref: Reactome:R-HSA-1971487 "CHPF,CHSY3 transfer GalNAc to chondroitin" +xref: Reactome:R-HSA-3595176 "Defective CHSY1 does not transfer GalNAc to chondroitin" +xref: Reactome:R-HSA-9632033 "CHSY1 transfers GalNAc to chondroitin" +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047239 +name: hydroxymandelonitrile glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP." [EC:2.4.1.178, RHEA:15961] +synonym: "cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.178] +synonym: "UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.178] +synonym: "UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.178] +xref: EC:2.4.1.178 +xref: KEGG_REACTION:R02709 +xref: MetaCyc:2.4.1.178-RXN +xref: RHEA:15961 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047240 +name: lactosylceramide beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP." [EC:2.4.1.179, RHEA:18413] +synonym: "UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.179] +synonym: "UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.179] +synonym: "uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity" RELATED [EC:2.4.1.179] +xref: EC:2.4.1.179 +xref: KEGG_REACTION:R04431 +xref: MetaCyc:2.4.1.179-RXN +xref: RHEA:18413 +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity + +[Term] +id: GO:0047241 +name: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." [RHEA:28366] +synonym: "LPS N-acetylmannosaminouronosyltransferase activity" EXACT [] +synonym: "ManNAcA transferase activity" RELATED [EC:2.4.1.180] +synonym: "UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity" RELATED [EC:2.4.1.180] +synonym: "uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity" RELATED [EC:2.4.1.180] +xref: EC:2.4.1.180 +xref: MetaCyc:2.4.1.180-RXN +xref: RHEA:28366 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047242 +name: hydroxyanthraquinone glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP." [EC:2.4.1.181, MetaCyc:2.4.1.181-RXN] +synonym: "anthraquinone-specific glucosyltransferase activity" RELATED [EC:2.4.1.181] +synonym: "UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity" RELATED [EC:2.4.1.181] +synonym: "UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity" RELATED [EC:2.4.1.181] +synonym: "uridine diphosphoglucose-anthraquinone glucosyltransferase activity" RELATED [EC:2.4.1.181] +xref: EC:2.4.1.181 +xref: MetaCyc:2.4.1.181-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047243 +name: flavanone 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP." [EC:2.4.1.185, MetaCyc:2.4.1.185-RXN] +synonym: "hesperetin 7-O-glucosyl-transferase activity" RELATED [EC:2.4.1.185] +synonym: "naringenin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.185] +synonym: "UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.185] +synonym: "UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.185] +synonym: "uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.185] +xref: EC:2.4.1.185 +xref: MetaCyc:2.4.1.185-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047244 +name: N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.187, MetaCyc:2.4.1.187-RXN] +synonym: "N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] +synonym: "UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] +synonym: "UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] +synonym: "uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity" RELATED [EC:2.4.1.187] +xref: EC:2.4.1.187 +xref: MetaCyc:TEICHOICSYN2-RXN +xref: RHEA:16053 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047245 +name: N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP." [EC:2.4.1.188, MetaCyc:2.4.1.188-RXN] +synonym: "UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity" RELATED [EC:2.4.1.188] +synonym: "UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.188] +synonym: "UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.188] +synonym: "uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity" RELATED [EC:2.4.1.188] +xref: EC:2.4.1.188 +xref: MetaCyc:2.4.1.188-RXN +xref: RHEA:20952 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047246 +name: luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP." [EC:2.4.1.190, RHEA:14149] +synonym: "LMT activity" RELATED [EC:2.4.1.190] +synonym: "luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.190] +synonym: "UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity" RELATED [EC:2.4.1.190] +synonym: "UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.190] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity" RELATED [EC:2.4.1.190] +xref: EC:2.4.1.190 +xref: KEGG_REACTION:R06827 +xref: MetaCyc:2.4.1.190-RXN +xref: RHEA:14149 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047247 +name: luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.191, RHEA:22116] +synonym: "LDT" RELATED [EC:2.4.1.191] +synonym: "UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity" RELATED [EC:2.4.1.191] +synonym: "UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.191] +synonym: "UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity" RELATED [EC:2.4.1.191] +synonym: "UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.191] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity" RELATED [EC:2.4.1.191] +xref: EC:2.4.1.191 +xref: KEGG_REACTION:R06828 +xref: MetaCyc:2.4.1.191-RXN +xref: RHEA:22116 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047248 +name: nuatigenin 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP." [EC:2.4.1.192, RHEA:19329] +synonym: "nuatigenin 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.192] +synonym: "UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.192] +synonym: "UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.192] +synonym: "uridine diphosphoglucose-nuatigenin glucosyltransferase activity" RELATED [EC:2.4.1.192] +xref: EC:2.4.1.192 +xref: KEGG_REACTION:R04577 +xref: MetaCyc:2.4.1.192-RXN +xref: RHEA:19329 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047249 +name: sarsapogenin 3-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP." [EC:2.4.1.193, RHEA:14461] +synonym: "sarsapogenin 3beta-glucosyltransferase activity" RELATED [EC:2.4.1.193] +synonym: "UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.193] +synonym: "UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.193] +synonym: "uridine diphosphoglucose-sarsapogenin glucosyltransferase activity" RELATED [EC:2.4.1.193] +xref: EC:2.4.1.193 +xref: KEGG_REACTION:R04359 +xref: MetaCyc:2.4.1.193-RXN +xref: RHEA:14461 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047250 +name: 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP." [EC:2.4.1.194, RHEA:15153] +synonym: "HBA glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "p-hydroxybenzoate glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "PHB glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "PHB-O-glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.194] +synonym: "uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity" RELATED [EC:2.4.1.194] +xref: EC:2.4.1.194 +xref: KEGG_REACTION:R01304 +xref: MetaCyc:2.4.1.194-RXN +xref: RHEA:15153 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047251 +name: thiohydroximate beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP." [EC:2.4.1.195, MetaCyc:2.4.1.195-RXN] +synonym: "desulfoglucosinolate-uridine diphosphate glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "N-hydroxythioamide S-beta-glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "thiohydroximate S-glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "UDPG:thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195] +synonym: "uridine diphosphoglucose-thiohydroximate glucosyltransferase activity" RELATED [EC:2.4.1.195] +xref: EC:2.4.1.195 +xref: MetaCyc:2.4.1.195-RXN +xref: RHEA:13757 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047252 +name: beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate." [EC:2.4.1.199, MetaCyc:2.4.1.199-RXN] +synonym: "beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.199] +synonym: "mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity" RELATED [EC:2.4.1.199] +xref: EC:2.4.1.199 +xref: MetaCyc:2.4.1.199-RXN +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047253 +name: alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP." [EC:2.4.1.201, MetaCyc:2.4.1.201-RXN] +synonym: "alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity" EXACT [] +synonym: "mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.201] +synonym: "N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] +synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] +synonym: "UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.201] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI" RELATED [EC:2.4.1.201] +synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity" RELATED [EC:2.4.1.201] +xref: EC:2.4.1.201 +xref: MetaCyc:2.4.1.201-RXN +xref: RHEA:19945 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047254 +name: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." [EC:2.4.1.202, MetaCyc:2.4.1.202-RXN] +synonym: "UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" RELATED [EC:2.4.1.202] +synonym: "UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" RELATED [EC:2.4.1.202] +synonym: "uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity" RELATED [EC:2.4.1.202] +xref: EC:2.4.1.202 +xref: MetaCyc:2.4.1.202-RXN +xref: RHEA:15541 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047255 +name: galactogen 6-beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP." [EC:2.4.1.205, MetaCyc:2.4.1.205-RXN] +synonym: "1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205] +synonym: "beta-(1,6)-D-galactosyltransferase activity" RELATED [EC:2.4.1.205] +synonym: "galactogen 6beta-galactosyltransferase activity" RELATED [EC:2.4.1.205] +synonym: "UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205] +synonym: "UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity" RELATED [EC:2.4.1.205] +synonym: "uridine diphosphogalactose-galactogen galactosyltransferase activity" RELATED [EC:2.4.1.205] +xref: EC:2.4.1.205 +xref: MetaCyc:2.4.1.205-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047256 +name: lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP." [EC:2.4.1.206, MetaCyc:2.4.1.206-RXN] +synonym: "beta1->3-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206] +synonym: "LA2 synthase activity" RELATED [EC:2.4.1.206] +synonym: "lactosylceramide beta-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206] +synonym: "UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206] +synonym: "uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.206] +xref: EC:2.4.1.206 +xref: MetaCyc:2.4.1.206-RXN +xref: RHEA:13905 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047257 +name: diglucosyl diacylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol." [EC:2.4.1.208, MetaCyc:2.4.1.208-RXN] +synonym: "DGlcDAG synthase activity" RELATED [EC:2.4.1.208] +synonym: "diglucosyl diacylglycerol (DGlcDAG) synthase activity" EXACT [] +synonym: "MGlcDAG (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208] +synonym: "monoglucosyl diacylglycerol (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208] +synonym: "UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity" RELATED [EC:2.4.1.208] +xref: EC:2.4.1.208 +xref: MetaCyc:2.4.1.208-RXN +xref: RHEA:19165 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047258 +name: sphingosine beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP." [EC:2.4.1.23, RHEA:19485] +synonym: "galactosyl-sphingosine transferase activity" RELATED [EC:2.4.1.23] +synonym: "psychosine-UDP galactosyltransferase activity" RELATED [EC:2.4.1.23] +synonym: "psychosine-uridine diphosphate galactosyltransferase activity" RELATED [EC:2.4.1.23] +synonym: "UDP-galactose:sphingosine 1-beta-galactotransferase activity" RELATED [EC:2.4.1.23] +synonym: "UDPgalactose:sphingosine 1-beta-galactotransferase activity" RELATED [EC:2.4.1.23] +synonym: "UDPgalactose:sphingosine O-galactosyl transferase activity" RELATED [EC:2.4.1.23] +synonym: "uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity" RELATED [EC:2.4.1.23] +xref: EC:2.4.1.23 +xref: KEGG_REACTION:R01928 +xref: MetaCyc:2.4.1.23-RXN +xref: RHEA:19485 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047259 +name: glucomannan 4-beta-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP." [EC:2.4.1.32, MetaCyc:2.4.1.32-RXN] +synonym: "GDP-man-beta-mannan mannosyltransferase activity" RELATED [EC:2.4.1.32] +synonym: "GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity" EXACT [] +synonym: "glucomannan 4-b-mannosyltransferase activity" EXACT [] +synonym: "glucomannan-synthase activity" EXACT [] +xref: EC:2.4.1.32 +xref: MetaCyc:2.4.1.32-RXN +is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity + +[Term] +id: GO:0047260 +name: alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP." [EC:2.4.1.36, MetaCyc:2.4.1.36-RXN] +synonym: "GDP-glucose-glucosephosphate glucosyltransferase activity" RELATED [EC:2.4.1.36] +synonym: "GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.36] +synonym: "GDPglucose-glucose-phosphate glucosyltransferase activity" RELATED [EC:2.4.1.36] +synonym: "GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.36] +synonym: "guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity" RELATED [EC:2.4.1.36] +synonym: "trehalose phosphate synthase (GDP-forming) activity" RELATED [EC:2.4.1.36] +xref: EC:2.4.1.36 +xref: MetaCyc:2.4.1.36-RXN +xref: RHEA:14605 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047261 +name: steroid N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP." [EC:2.4.1.39, RHEA:14153] +synonym: "hydroxy steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39] +synonym: "steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39] +synonym: "UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39] +synonym: "uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.39] +xref: EC:2.4.1.39 +xref: KEGG_REACTION:R04451 +xref: MetaCyc:2.4.1.39-RXN +xref: RHEA:14153 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047262 +name: polygalacturonate 4-alpha-galacturonosyltransferase activity +namespace: molecular_function +alt_id: GO:0050375 +def: "Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP." [EC:2.4.1.43, MetaCyc:2.4.1.43-RXN] +synonym: "UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity" RELATED [EC:2.4.1.43] +synonym: "UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity" RELATED [EC:2.4.1.43] +synonym: "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity" RELATED [EC:2.4.1.43] +xref: EC:2.4.1.43 +xref: MetaCyc:2.4.1.43-RXN +xref: RHEA:13573 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047263 +name: N-acylsphingosine galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP." [EC:2.4.1.47, MetaCyc:2.4.1.47-RXN] +synonym: "UDP galactose-N-acylsphingosine galactosyltransferase activity" RELATED [EC:2.4.1.47] +synonym: "UDP-galactose:N-acylsphingosine D-galactosyltransferase activity" RELATED [EC:2.4.1.47] +synonym: "UDPgalactose:N-acylsphingosine D-galactosyltransferase activity" RELATED [EC:2.4.1.47] +synonym: "uridine diphosphogalactose-acylsphingosine galactosyltransferase activity" RELATED [EC:2.4.1.47] +xref: EC:2.4.1.47 +xref: MetaCyc:2.4.1.47-RXN +xref: Reactome:R-HSA-6785933 "UGT8 transfers Gal from UDP-Gal to CERA" +xref: RHEA:13093 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047264 +name: heteroglycan alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48] +synonym: "GDP mannose alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "heteropolysaccharide alpha-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.48 +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047265 +name: poly(glycerol-phosphate) alpha-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP." [EC:2.4.1.52, MetaCyc:2.4.1.52-RXN] +synonym: "UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" RELATED [EC:2.4.1.52] +synonym: "UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.52] +synonym: "UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.52] +synonym: "uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity" RELATED [EC:2.4.1.52] +xref: EC:2.4.1.52 +xref: MetaCyc:2.4.1.52-RXN +xref: RHEA:15845 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047266 +name: poly(ribitol-phosphate) beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP." [EC:2.4.1.53, MetaCyc:2.4.1.53-RXN] +synonym: "UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" RELATED [EC:2.4.1.53] +synonym: "UDP-D-glucose polyribitol phosphate glucosyl transferase activity" RELATED [EC:2.4.1.53] +synonym: "UDP-D-glucose:polyribitol phosphate glucosyl transferase activity" RELATED [EC:2.4.1.53] +synonym: "UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.53] +synonym: "UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.53] +synonym: "uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity" RELATED [EC:2.4.1.53] +xref: EC:2.4.1.53 +xref: MetaCyc:2.4.1.53-RXN +xref: RHEA:10068 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047267 +name: undecaprenyl-phosphate mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol." [EC:2.4.1.54] +synonym: "GDP mannose-undecaprenyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.54] +synonym: "GDP-D-mannose:lipid phosphate transmannosylase activity" RELATED [EC:2.4.1.54] +synonym: "GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity" RELATED [EC:2.4.1.54] +synonym: "guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity" RELATED [EC:2.4.1.54] +xref: EC:2.4.1.54 +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0047268 +name: galactinol-raffinose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol." [EC:2.4.1.67, MetaCyc:2.4.1.67-RXN] +synonym: "alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity" RELATED [EC:2.4.1.67] +synonym: "stachyose synthetase activity" RELATED [EC:2.4.1.67] +xref: EC:2.4.1.67 +xref: MetaCyc:2.4.1.67-RXN +xref: RHEA:20776 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047269 +name: poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP." [EC:2.4.1.70, MetaCyc:2.4.1.70-RXN] +synonym: "UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.70] +synonym: "UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity" RELATED [EC:2.4.1.70] +synonym: "uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.70] +xref: EC:2.4.1.70 +xref: MetaCyc:2.4.1.70-RXN +xref: RHEA:21012 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0047270 +name: lipopolysaccharide glucosyltransferase II activity +namespace: molecular_function +def: "Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP." [EC:2.4.1.73, GOC:mr, GOC:pr, MetaCyc:2.4.1.73-RXN] +synonym: "LPS glucosyltransferase II activity" EXACT [] +synonym: "UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.73] +synonym: "UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.73] +synonym: "uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity" RELATED [EC:2.4.1.73] +xref: EC:2.4.1.73 +xref: MetaCyc:2.4.1.73-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047271 +name: glycosaminoglycan galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP." [EC:2.4.1.74, MetaCyc:2.4.1.74-RXN] +synonym: "UDP-galactose:glycosaminoglycan D-galactosyltransferase activity" RELATED [EC:2.4.1.74] +synonym: "UDPgalactose:glycosaminoglycan D-galactosyltransferase activity" RELATED [EC:2.4.1.74] +synonym: "uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity" RELATED [EC:2.4.1.74] +xref: EC:2.4.1.74 +xref: MetaCyc:2.4.1.74-RXN +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047272 +name: phosphopolyprenol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP." [EC:2.4.1.78, MetaCyc:2.4.1.78-RXN] +synonym: "UDP-glucose:phosphopolyprenol D-glucosyltransferase activity" RELATED [EC:2.4.1.78] +synonym: "UDPglucose:phosphopolyprenol D-glucosyltransferase activity" RELATED [EC:2.4.1.78] +synonym: "UDPglucose:polyprenol monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.78] +synonym: "uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity" RELATED [EC:2.4.1.78] +xref: EC:2.4.1.78 +xref: MetaCyc:2.4.1.78-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047273 +name: galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity +namespace: molecular_function +alt_id: GO:0047226 +def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide." [EC:2.4.1.79, MetaCyc:2.4.1.79-RXN] +synonym: "beta-3GalNAc-T1 activity" RELATED [EC:2.4.1.79] +synonym: "beta3GalNAc-T1" RELATED [EC:2.4.1.79] +synonym: "galactosylgalactosylglucosylceramide beta-D- activity" RELATED [EC:2.4.1.79] +synonym: "globoside synthase activity" RELATED [EC:2.4.1.79] +synonym: "globoside synthetase activity" RELATED [EC:2.4.1.79] +synonym: "globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79] +synonym: "globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity" EXACT [] +synonym: "UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.79] +synonym: "UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.79] +synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79] +synonym: "UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79] +synonym: "uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.79] +xref: EC:2.4.1.79 +xref: MetaCyc:2.4.1.79-RXN +xref: Reactome:R-HSA-8878914 "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer" +xref: RHEA:22252 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047274 +name: galactinol-sucrose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol." [EC:2.4.1.82, MetaCyc:2.4.1.82-RXN] +synonym: "1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.82] +synonym: "alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.82] +synonym: "galactinol:sucrose 6-galactosyl transferase activity" EXACT [] +synonym: "galactosyltransferase, galactinol-sucrose" EXACT [] +synonym: "raffinose synthase activity" EXACT [] +xref: EC:2.4.1.82 +xref: MetaCyc:2.4.1.82-RXN +xref: RHEA:20161 +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0047275 +name: glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.86, MetaCyc:2.4.1.86-RXN] +synonym: "GalT-4" RELATED [EC:2.4.1.86] +synonym: "paragloboside synthase activity" RELATED [EC:2.4.1.86] +synonym: "UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.86] +synonym: "UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity" RELATED [EC:2.4.1.86] +synonym: "uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.86] +xref: EC:2.4.1.86 +xref: MetaCyc:2.4.1.86-RXN +xref: RHEA:16045 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047276 +name: N-acetyllactosaminide 3-alpha-galactosyltransferase activity +namespace: molecular_function +alt_id: GO:0003946 +def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP." [EC:2.4.1.87, MetaCyc:2.4.1.87-RXN, RHEA:13013] +synonym: "alpha-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" EXACT [] +synonym: "glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "N-acetyllactosaminide alpha-1,3-galactosyltransferase activity" EXACT [] +synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.87] +synonym: "uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity" RELATED [EC:2.4.1.87] +xref: EC:2.4.1.87 +xref: MetaCyc:2.4.1.151-RXN +xref: RHEA:13013 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047277 +name: globoside alpha-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.88, MetaCyc:2.4.1.88-RXN] +synonym: "Forssman synthase activity" RELATED [EC:2.4.1.88] +synonym: "globoside acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.88] +synonym: "UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity" RELATED [EC:2.4.1.88] +synonym: "uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity" RELATED [EC:2.4.1.88] +xref: EC:2.4.1.88 +xref: MetaCyc:2.4.1.88-RXN +xref: RHEA:22164 +is_a: GO:0008376 ! acetylgalactosaminyltransferase activity + +[Term] +id: GO:0047278 +name: bilirubin-glucuronoside glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside." [RHEA:16885] +synonym: "bilirubin glucuronoside glucuronosyltransferase activity" EXACT [] +synonym: "bilirubin monoglucuronide transglucuronidase activity" EXACT [] +synonym: "bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity" EXACT [] +xref: KEGG_REACTION:R00062 +xref: MetaCyc:2.4.1.95-RXN +xref: RHEA:16885 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0047279 +name: sn-glycerol-3-phosphate 1-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP." [EC:2.4.1.96, RHEA:20341] +synonym: "glycerol 3-phosphate 1alpha-galactosyltransferase activity" RELATED [EC:2.4.1.96] +synonym: "isofloridoside-phosphate synthase activity" RELATED [EC:2.4.1.96] +synonym: "UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity" RELATED [EC:2.4.1.96] +synonym: "UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96] +synonym: "UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96] +synonym: "UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.96] +synonym: "uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity" RELATED [EC:2.4.1.96] +xref: EC:2.4.1.96 +xref: KEGG_REACTION:R00854 +xref: MetaCyc:2.4.1.96-RXN +xref: RHEA:20341 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047280 +name: nicotinamide phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide." [RHEA:16149] +synonym: "nicotinamide mononucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.12] +synonym: "nicotinamide mononucleotide synthetase activity" RELATED [EC:2.4.2.12] +synonym: "nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.12] +synonym: "NMN diphosphorylase activity" RELATED [EC:2.4.2.12] +synonym: "NMN pyrophosphorylase activity" RELATED [EC:2.4.2.12] +synonym: "NMN synthetase activity" RELATED [EC:2.4.2.12] +xref: EC:2.4.2.12 +xref: KEGG_REACTION:R01271 +xref: MetaCyc:2.4.2.12-RXN +xref: Reactome:R-HSA-197250 "NAMPT transfers PRIB to NAM to form NAMN" +xref: RHEA:16149 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047281 +name: dioxotetrahydropyrimidine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine." [EC:2.4.2.20, MetaCyc:2.4.2.20-RXN] +synonym: "2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine phosphoribosyl transferase activity" RELATED [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity" RELATED [EC:2.4.2.20] +synonym: "dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity" RELATED [EC:2.4.2.20] +xref: EC:2.4.2.20 +xref: MetaCyc:2.4.2.20-RXN +xref: RHEA:10232 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047282 +name: dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+)." [EC:2.4.2.27, RHEA:24392] +synonym: "dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27] +synonym: "dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27] +synonym: "thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity" RELATED [EC:2.4.2.27] +xref: EC:2.4.2.27 +xref: KEGG_REACTION:R04222 +xref: MetaCyc:2.4.2.27-RXN +xref: RHEA:24392 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047283 +name: dolichyl-phosphate D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP." [EC:2.4.2.32, MetaCyc:2.4.2.32-RXN] +synonym: "UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity" RELATED [EC:2.4.2.32] +xref: EC:2.4.2.32 +xref: MetaCyc:2.4.2.32-RXN +xref: RHEA:15361 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0047284 +name: dolichyl-xylosyl-phosphate-protein xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein." [EC:2.4.2.33, MetaCyc:2.4.2.33-RXN] +synonym: "dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity" RELATED [EC:2.4.2.33] +xref: EC:2.4.2.33 +xref: MetaCyc:2.4.2.33-RXN +xref: RHEA:18361 +is_a: GO:0042285 ! xylosyltransferase activity + +[Term] +id: GO:0047285 +name: flavonol-3-O-glycoside xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP." [EC:2.4.2.35, MetaCyc:2.4.2.35-RXN] +synonym: "UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.35] +xref: EC:2.4.2.35 +xref: MetaCyc:2.4.2.35-RXN +xref: RHEA:19701 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0047286 +name: NAD+-diphthamide ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide." [EC:2.4.2.36] +synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.36] +synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.36] +synonym: "NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity" RELATED [EC:2.4.2.36] +synonym: "NAD-diphthamide ADP-ribosyltransferase activity" EXACT [] +xref: EC:2.4.2.36 +xref: MetaCyc:RXN-11372 +xref: Reactome:R-HSA-5336421 "DT fragment A ADP-ribosylates target cell EEF" +xref: RHEA:11820 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047287 +name: lactosylceramide alpha-2,6-N-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP." [EC:2.4.99.11, MetaCyc:2.4.99.11-RXN] +synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.11] +synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.11] +synonym: "CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity" RELATED [EC:2.4.99.11] +synonym: "CMP-sialic acid:lactosylceramide sialyltransferase activity" RELATED [EC:2.4.99.11] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.11] +xref: EC:2.4.99.11 +xref: MetaCyc:2.4.99.11-RXN +xref: RHEA:21552 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047288 +name: monosialoganglioside sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP." [EC:2.4.99.2, MetaCyc:2.4.99.2-RXN] +synonym: "CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.2] +xref: EC:2.4.99.2 +xref: MetaCyc:2.4.99.2-RXN +xref: RHEA:18021 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047289 +name: galactosyldiacylglycerol alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+)." [EC:2.4.99.5, RHEA:11664] +synonym: "CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.5] +xref: EC:2.4.99.5 +xref: KEGG_REACTION:R03468 +xref: MetaCyc:2.4.99.5-RXN +xref: RHEA:11664 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047290 +name: (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP." [EC:2.4.99.7, RHEA:53896] +synonym: "(alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.99.7] +synonym: "(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity" EXACT [] +synonym: "alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.99.7] +synonym: "CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity" RELATED [EC:2.4.99.7] +synonym: "cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.99.7] +synonym: "NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity" RELATED [EC:2.4.99.7] +synonym: "sialyltransferase 3C activity" RELATED [EC:2.4.99.7] +synonym: "sialyltransferase 7D activity" RELATED [EC:2.4.99.7] +synonym: "SIAT7" RELATED [EC:2.4.99.7] +synonym: "ST6GALNAC activity" RELATED [EC:2.4.99.7] +xref: EC:2.4.99.7 +xref: KEGG_REACTION:R04635 +xref: MetaCyc:2.4.99.7-RXN +xref: Reactome:R-HSA-981809 "ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen" +xref: RHEA:53896 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047291 +name: lactosylceramide alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3." [EC:2.4.99.9, MetaCyc:2.4.99.9-RXN] +synonym: "CMP-acetylneuraminate-lactosylceramide-sialyltransferase" BROAD [EC:2.4.99.9] +synonym: "CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity" RELATED [EC:2.4.99.9] +synonym: "CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity" RELATED [EC:2.4.99.9] +synonym: "CMP-sialic acid:lactosylceramide-sialyltransferase activity" RELATED [EC:2.4.99.9] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity" RELATED [EC:2.4.99.9] +synonym: "cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase" BROAD [EC:2.4.99.9] +synonym: "ganglioside GM3 synthase activity" RELATED [EC:2.4.99.9] +synonym: "ganglioside GM3 synthetase activity" RELATED [EC:2.4.99.9] +synonym: "GM3 synthase activity" RELATED [EC:2.4.99.9] +synonym: "GM3 synthetase activity" RELATED [EC:2.4.99.9] +synonym: "SAT 1" RELATED [EC:2.4.99.9] +xref: EC:2.4.99.9 +xref: MetaCyc:2.4.99.9-RXN +xref: RHEA:18417 +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0047292 +name: trihydroxypterocarpan dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate." [EC:2.5.1.36, MetaCyc:2.5.1.36-RXN] +synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" RELATED [EC:2.5.1.36] +synonym: "dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity" RELATED [EC:2.5.1.36] +synonym: "dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity" RELATED [EC:2.5.1.36] +synonym: "dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity" RELATED [EC:2.5.1.36] +xref: EC:2.5.1.36 +xref: MetaCyc:2.5.1.36-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047293 +name: 4-hydroxybenzoate nonaprenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate." [EC:2.5.1.39, MetaCyc:2.5.1.39-RXN] +synonym: "4-hydroxybenzoate transferase activity" RELATED [EC:2.5.1.39] +synonym: "nonaprenyl-4-hydroxybenzoate transferase activity" RELATED [EC:2.5.1.39] +synonym: "p-hydroxybenzoate dimethylallyltransferase activity" RELATED [EC:2.5.1.39] +synonym: "p-hydroxybenzoate polyprenyltransferase activity" RELATED [EC:2.5.1.39] +synonym: "p-hydroxybenzoic acid-polyprenyl transferase activity" RELATED [EC:2.5.1.39] +synonym: "p-hydroxybenzoic-polyprenyl transferase activity" RELATED [EC:2.5.1.39] +synonym: "solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity" RELATED [EC:2.5.1.39] +xref: EC:2.5.1.39 +xref: MetaCyc:2.5.1.39-RXN +xref: RHEA:17709 +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0047294 +name: phosphoglycerol geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.41, RHEA:23404] +synonym: "geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41] +synonym: "geranylgeranyl-transferase activity" RELATED [EC:2.5.1.41] +synonym: "glycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.41] +xref: EC:2.5.1.41 +xref: KEGG_REACTION:R04158 +xref: MetaCyc:2.5.1.41-RXN +xref: RHEA:23404 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047295 +name: geranylgeranylglycerol-phosphate geranylgeranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate." [EC:2.5.1.42, RHEA:18109] +synonym: "geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42] +synonym: "geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity" RELATED [EC:2.5.1.42] +synonym: "geranylgeranyltransferase II" RELATED [EC:2.5.1.42] +xref: EC:2.5.1.42 +xref: KEGG_REACTION:R04520 +xref: MetaCyc:2.5.1.42-RXN +xref: RHEA:18109 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047296 +name: homospermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine." [EC:2.5.1.44, MetaCyc:2.5.1.44-RXN] +synonym: "putrescine:putrescine 4-aminobutyltransferase (ammonia-forming)" RELATED [EC:2.5.1.44] +xref: EC:2.5.1.44 +xref: MetaCyc:2.5.1.44-RXN +xref: RHEA:18645 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047297 +name: asparagine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate." [EC:2.6.1.14, MetaCyc:2.6.1.14-RXN] +synonym: "asparagine--oxo-acid aminotransferase activity" RELATED [EC:2.6.1.14] +synonym: "asparagine-keto acid aminotransferase activity" RELATED [EC:2.6.1.14] +synonym: "asparagine-oxo-acid aminotransferase activity" EXACT [] +synonym: "L-asparagine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.14] +xref: EC:2.6.1.14 +xref: MetaCyc:2.6.1.14-RXN +xref: RHEA:19813 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047298 +name: (S)-3-amino-2-methylpropionate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate." [EC:2.6.1.22, RHEA:13993] +synonym: "(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.22] +synonym: "(S)-3-amino-2-methylpropionate aminotransferase activity" EXACT [] +synonym: "beta-aminobutyric transaminase activity" RELATED [EC:2.6.1.22] +synonym: "beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.22] +synonym: "L-3-aminoisobutyrate aminotransferase activity" RELATED [EC:2.6.1.22] +synonym: "L-3-aminoisobutyrate transaminase activity" RELATED [EC:2.6.1.22] +synonym: "L-3-aminoisobutyric aminotransferase activity" RELATED [EC:2.6.1.22] +synonym: "L-AIBAT activity" RELATED [EC:2.6.1.22] +xref: EC:2.6.1.22 +xref: KEGG_REACTION:R04188 +xref: MetaCyc:2.6.1.22-RXN +xref: RHEA:13993 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047299 +name: tryptophan-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine." [EC:2.6.1.28, RHEA:13741] +synonym: "L-tryptophan-alpha-ketoisocaproate aminotransferase activity" RELATED [EC:2.6.1.28] +synonym: "L-tryptophan:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.28] +synonym: "tryptophan--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.28] +synonym: "tryptophan-phenylpyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.28 +xref: KEGG_REACTION:R01376 +xref: MetaCyc:2.6.1.28-RXN +xref: RHEA:13741 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047300 +name: pyridoxamine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal." [EC:2.6.1.30, RHEA:12841] +synonym: "pyridoxamine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.30] +synonym: "pyridoxamine-pyruvate aminotransferase activity" EXACT [] +synonym: "pyridoxamine-pyruvic transaminase" BROAD [EC:2.6.1.30] +synonym: "pyridoxamine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.30] +synonym: "pyridoxamineu-pyruvic transaminase activity" RELATED [EC:2.6.1.30] +xref: EC:2.6.1.30 +xref: KEGG_REACTION:R01712 +xref: MetaCyc:2.6.1.30-RXN +xref: RHEA:12841 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047301 +name: valine-3-methyl-2-oxovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine." [EC:2.6.1.32, RHEA:11468] +synonym: "L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity" RELATED [EC:2.6.1.32] +synonym: "valine--3-methyl-2-oxovalerate aminotransferase activity" RELATED [EC:2.6.1.32] +synonym: "valine--isoleucine aminotransferase activity" RELATED [EC:2.6.1.32] +synonym: "valine--isoleucine transaminase activity" RELATED [EC:2.6.1.32] +synonym: "valine-2-keto-methylvalerate aminotransferase activity" RELATED [EC:2.6.1.32] +synonym: "valine-3-methyl-2-oxovalerate aminotransferase activity" EXACT [] +xref: EC:2.6.1.32 +xref: KEGG_REACTION:R02200 +xref: MetaCyc:2.6.1.32-RXN +xref: RHEA:11468 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047302 +name: UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose." [PMID:16286454, RHEA:31663] +synonym: "UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.34] +synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" EXACT [] +synonym: "UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity" EXACT [] +synonym: "uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity" RELATED [EC:2.6.1.34] +xref: EC:2.6.1.34 +xref: KEGG_REACTION:R04529 +xref: MetaCyc:2.6.1.34-RXN +xref: RHEA:31663 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047303 +name: glycine-oxaloacetate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate." [EC:2.6.1.35, RHEA:17141] +synonym: "glycine--oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.35] +synonym: "glycine-oxalacetate aminotransferase activity" RELATED [EC:2.6.1.35] +synonym: "glycine-oxaloacetate aminotransferase activity" EXACT [] +synonym: "glycine:oxaloacetate aminotransferase activity" RELATED [EC:2.6.1.35] +xref: EC:2.6.1.35 +xref: KEGG_REACTION:R00373 +xref: MetaCyc:2.6.1.35-RXN +xref: RHEA:17141 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047304 +name: 2-aminoethylphosphonate-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde." [EC:2.6.1.37, RHEA:17021] +synonym: "(2-aminoethyl)phosphonate aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate transaminase activity" RELATED [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "(2-aminoethyl)phosphonic acid aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.37] +synonym: "2-aminoethylphosphonate-pyruvate aminotransferase activity" EXACT [] +xref: EC:2.6.1.37 +xref: KEGG_REACTION:R04152 +xref: MetaCyc:2.6.1.37-RXN +xref: RHEA:17021 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047305 +name: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity +namespace: molecular_function +alt_id: GO:0047314 +def: "Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine." [EC:2.6.1.40, RHEA:18393] +comment: Note that this function was EC:2.6.1.61. +synonym: "(R)-3-amino-2-methylpropanoate aminotransferase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropanoate transaminase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.40] +synonym: "(R)-3-amino-2-methylpropionate transaminase activity" EXACT [] +synonym: "(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.40] +synonym: "(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity" EXACT [] +synonym: "beta-aminoisobutyrate--pyruvate transaminase activity" RELATED [EC:2.6.1.40] +synonym: "beta-aminoisobutyrate-pyruvate aminotransferase activity" RELATED [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate--pyruvate transaminase activity" RELATED [EC:2.6.1.40] +synonym: "D-3-aminoisobutyrate-pyruvate transaminase activity" RELATED [EC:2.6.1.40] +synonym: "D-AIBAT activity" RELATED [EC:2.6.1.40] +synonym: "D-beta-aminoisobutyrate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.40] +xref: EC:2.6.1.40 +xref: KEGG_REACTION:R02050 +xref: MetaCyc:2.6.1.40-RXN +xref: Reactome:R-HSA-909780 "(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine" +xref: RHEA:18393 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047306 +name: D-methionine-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine." [EC:2.6.1.41, RHEA:23836] +synonym: "D-methionine aminotransferase activity" RELATED [EC:2.6.1.41] +synonym: "D-methionine transaminase activity" RELATED [EC:2.6.1.41] +synonym: "D-methionine--pyruvate aminotransferase activity" RELATED [EC:2.6.1.41] +synonym: "D-methionine-pyruvate aminotransferase activity" EXACT [] +synonym: "D-methionine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.41] +xref: EC:2.6.1.41 +xref: KEGG_REACTION:R03001 +xref: MetaCyc:2.6.1.41-RXN +xref: RHEA:23836 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047307 +name: diaminobutyrate-pyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde." [EC:2.6.1.46, RHEA:12380] +synonym: "diaminobutyrate--pyruvate aminotransferase activity" RELATED [EC:2.6.1.46] +synonym: "diaminobutyrate-pyruvate aminotransferase activity" EXACT [] +synonym: "L-2,4-diaminobutanoate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.46] +synonym: "L-diaminobutyric acid transaminase activity" RELATED [EC:2.6.1.46] +xref: EC:2.6.1.46 +xref: KEGG_REACTION:R02293 +xref: MetaCyc:2.6.1.46-RXN +xref: RHEA:12380 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047308 +name: alanine-oxomalonate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate." [EC:2.6.1.47, RHEA:18809] +synonym: "alanine--oxomalonate aminotransferase activity" RELATED [EC:2.6.1.47] +synonym: "alanine-ketomalonate (mesoxalate) transaminase activity" RELATED [EC:2.6.1.47] +synonym: "alanine-oxomalonate aminotransferase activity" EXACT [] +synonym: "L-alanine-ketomalonate transaminase activity" RELATED [EC:2.6.1.47] +synonym: "L-alanine:oxomalonate aminotransferase activity" RELATED [EC:2.6.1.47] +xref: EC:2.6.1.47 +xref: KEGG_REACTION:R02970 +xref: MetaCyc:2.6.1.47-RXN +xref: RHEA:18809 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047309 +name: dihydroxyphenylalanine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.49, RHEA:15273] +synonym: "3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.49] +synonym: "aspartate-DOPP transaminase (ADT)" RELATED [EC:2.6.1.49] +synonym: "dihydroxyphenylalanine aminotransferase activity" EXACT [] +synonym: "DOPA aminotransferase activity" RELATED [EC:2.6.1.49] +synonym: "dopa transaminase activity" RELATED [EC:2.6.1.49] +synonym: "glutamate-DOPP transaminase (GDT)" RELATED [EC:2.6.1.49] +synonym: "L-dopa transaminase activity" RELATED [EC:2.6.1.49] +synonym: "phenylalanine-DOPP transaminase (PDT)" RELATED [EC:2.6.1.49] +xref: EC:2.6.1.49 +xref: KEGG_REACTION:R02077 +xref: MetaCyc:2.6.1.49-RXN +xref: RHEA:15273 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047310 +name: glutamine-scyllo-inositol transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate." [EC:2.6.1.50, RHEA:22920] +synonym: "glutamine scyllo-inosose aminotransferase activity" RELATED [EC:2.6.1.50] +synonym: "glutamine--scyllo-inosose aminotransferase activity" RELATED [EC:2.6.1.50] +synonym: "glutamine--scyllo-inosose transaminase activity" RELATED [EC:2.6.1.50] +synonym: "glutamine-scyllo-inosose aminotransferase activity" EXACT [] +synonym: "glutamine-scyllo-inosose transaminase activity" EXACT [] +synonym: "L-glutamine-keto-scyllo-inositol aminotransferase activity" RELATED [EC:2.6.1.50] +synonym: "L-glutamine-scyllo-inosose transaminase activity" RELATED [EC:2.6.1.50] +synonym: "L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity" RELATED [EC:2.6.1.50] +xref: EC:2.6.1.50 +xref: KEGG_REACTION:R02781 +xref: MetaCyc:2.6.1.50-RXN +xref: RHEA:22920 +is_a: GO:0070548 ! L-glutamine aminotransferase activity + +[Term] +id: GO:0047311 +name: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine." [EC:2.6.1.56, RHEA:15497] +synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity" EXACT [] +synonym: "1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity" RELATED [EC:2.6.1.56] +synonym: "guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity" RELATED [EC:2.6.1.56] +synonym: "L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity" RELATED [EC:2.6.1.56] +xref: EC:2.6.1.56 +xref: KEGG_REACTION:R03502 +xref: MetaCyc:2.6.1.56-RXN +xref: RHEA:15497 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047312 +name: L-phenylalanine:pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine." [EC:2.6.1.58, MetaCyc:2.6.1.58-RXN] +synonym: "histidine aminotransferase activity" RELATED [GOC:kad] +synonym: "histidine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.58, GOC:kad] +synonym: "L-histidine:pyruvate aminotransferase activity" RELATED [GOC:kad] +synonym: "L-phenylalanine(L-histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] +synonym: "L-phenylalanine:pyruvate transaminase activity" EXACT [GOC:kad] +synonym: "phenylalanine (histidine) aminotransferase activity" BROAD [EC:2.6.1.58] +synonym: "phenylalanine(histidine) aminotransferase activity" BROAD [] +synonym: "phenylalanine(histidine) transaminase activity" BROAD [EC:2.6.1.58] +synonym: "phenylalanine(histidine):pyruvate aminotransferase activity" BROAD [EC:2.6.1.58] +xref: EC:2.6.1.58 +xref: KEGG_REACTION:R00692 +xref: MetaCyc:2.6.1.58-RXN +xref: Reactome:R-HSA-893593 "phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine" +xref: RHEA:13053 +is_a: GO:0070546 ! L-phenylalanine aminotransferase activity + +[Term] +id: GO:0047313 +name: aromatic-amino-acid-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid." [EC:2.6.1.60, MetaCyc:2.6.1.60-RXN] +synonym: "aromatic-amino-acid--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.60] +synonym: "aromatic-amino-acid-glyoxylate aminotransferase activity" EXACT [] +synonym: "aromatic-amino-acid:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.60] +xref: EC:2.6.1.60 +xref: MetaCyc:2.6.1.60-RXN +xref: RHEA:10900 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047315 +name: kynurenine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine." [EC:2.6.1.63, RHEA:19249] +synonym: "kynurenine--glyoxylate aminotransferase activity" RELATED [EC:2.6.1.63] +synonym: "kynurenine-glyoxylate aminotransferase activity" EXACT [] +synonym: "L-kynurenine:glyoxylate aminotransferase (cyclizing)" RELATED [EC:2.6.1.63] +xref: EC:2.6.1.63 +xref: KEGG_REACTION:R01957 +xref: MetaCyc:2.6.1.63-RXN +xref: RHEA:19249 +is_a: GO:0036137 ! kynurenine aminotransferase activity + +[Term] +id: GO:0047316 +name: glutamine-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine." [EC:2.6.1.64, RHEA:17593] +synonym: "glutamine transaminase K activity" RELATED [EC:2.6.1.64] +synonym: "glutamine--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.64] +synonym: "glutamine-phenylpyruvate aminotransferase activity" EXACT [] +synonym: "L-glutamine:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.64] +xref: EC:2.6.1.64 +xref: KEGG_REACTION:R01375 +xref: MetaCyc:2.6.1.64-RXN +xref: RHEA:17593 +is_a: GO:0070548 ! L-glutamine aminotransferase activity + +[Term] +id: GO:0047317 +name: N6-acetyl-beta-lysine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate." [EC:2.6.1.65, MetaCyc:2.6.1.65-RXN] +synonym: "6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.65] +synonym: "epsilon-acetyl-beta-lysine aminotransferase activity" RELATED [EC:2.6.1.65] +synonym: "N(6)-acetyl-beta-lysine aminotransferase activity" RELATED [EC:2.6.1.65] +synonym: "N6-acetyl-beta-lysine aminotransferase activity" EXACT [] +xref: EC:2.6.1.65 +xref: MetaCyc:2.6.1.65-RXN +xref: RHEA:16889 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047319 +name: aspartate-phenylpyruvate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate." [EC:2.6.1.70, RHEA:14097] +synonym: "aspartate--phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.70] +synonym: "aspartate-phenylpyruvate aminotransferase activity" EXACT [] +synonym: "L-aspartate:phenylpyruvate aminotransferase activity" RELATED [EC:2.6.1.70] +xref: EC:2.6.1.70 +xref: KEGG_REACTION:R00695 +xref: MetaCyc:2.6.1.70-RXN +xref: RHEA:14097 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047320 +name: D-4-hydroxyphenylglycine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate." [EC:2.6.1.72, RHEA:15589] +synonym: "D-4-hydroxyphenylglycine aminotransferase activity" EXACT [] +synonym: "D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.72] +synonym: "D-hydroxyphenylglycine aminotransferase activity" RELATED [EC:2.6.1.72] +xref: EC:2.6.1.72 +xref: KEGG_REACTION:R04234 +xref: MetaCyc:2.6.1.72-RXN +xref: RHEA:15589 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047321 +name: diphosphate-protein phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein." [EC:2.7.99.1, MetaCyc:2.7.99.1-RXN] +synonym: "diphosphate:microsomal-membrane-protein O-phosphotransferase activity" BROAD [EC:2.7.99.1] +synonym: "DiPPT" RELATED [EC:2.7.99.1] +synonym: "pyrophosphate-protein phosphotransferase activity" RELATED [EC:2.7.99.1] +synonym: "pyrophosphate:protein phosphotransferase activity" RELATED [EC:2.7.99.1] +synonym: "triphosphate-protein phosphotransferase activity" RELATED [EC:2.7.99.1] +synonym: "triphosphate:microsomal-membrane-protein phosphotransferase activity" RELATED [EC:2.7.99.1] +xref: EC:2.7.99.1 +xref: MetaCyc:2.7.99.1-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047322 +name: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP." [EC:2.7.11.31, MetaCyc:2.7.1.109-RXN] +synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "3-hydroxy-3-methylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "AMPK" RELATED [EC:2.7.11.31] +synonym: "ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity" RELATED [EC:2.7.11.31] +synonym: "beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "HMG-CoA reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity" RELATED [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity" RELATED [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity" RELATED [EC:2.7.11.31] +synonym: "hydroxymethylglutaryl-CoA reductase kinase activity" RELATED [EC:2.7.11.31] +synonym: "reductase kinase activity" BROAD [EC:2.7.11.31] +synonym: "STK29" RELATED [EC:2.7.11.31] +xref: EC:2.7.11.31 +xref: MetaCyc:2.7.1.109-RXN +xref: RHEA:23172 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047323 +name: [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.4] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity" RELATED [EC:2.7.11.4] +synonym: "[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity" EXACT [] +synonym: "ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity" RELATED [EC:2.7.11.4] +synonym: "BCK" RELATED [EC:2.7.11.4] +synonym: "BCKD kinase activity" RELATED [EC:2.7.11.4] +synonym: "BCODH kinase activity" RELATED [EC:2.7.11.4] +synonym: "branched-chain 2-oxo acid dehydrogenase kinase activity" RELATED [EC:2.7.11.4] +synonym: "branched-chain alpha-ketoacid dehydrogenase kinase activity" RELATED [EC:2.7.11.4] +synonym: "branched-chain keto acid dehydrogenase kinase activity" RELATED [EC:2.7.11.4] +synonym: "branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.4] +synonym: "STK2" RELATED [EC:2.7.11.4] +xref: EC:2.7.11.4 +xref: MetaCyc:2.7.11.4-RXN +xref: Reactome:R-HSA-5693148 "BCKDK phosphorylates BCKDH" +xref: RHEA:17301 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047324 +name: phosphoenolpyruvate-glycerone phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate." [EC:2.7.1.121, RHEA:18381] +synonym: "phosphoenolpyruvate:glycerone phosphotransferase activity" RELATED [EC:2.7.1.121] +xref: EC:2.7.1.121 +xref: KEGG_REACTION:R01012 +xref: MetaCyc:2.7.1.121-RXN +xref: RHEA:18381 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047325 +name: inositol tetrakisphosphate 1-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.134, MetaCyc:2.7.1.134-RXN] +synonym: "1D-myo-inositol-tetrakisphosphate 1-kinase activity" RELATED [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] +synonym: "ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.134] +synonym: "inositol 3,4,5,6-tetrakisphosphate 1-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 1-kinase activity" BROAD [] +synonym: "inositol-trisphosphate 5-kinase activity" RELATED [EC:2.7.1.134] +synonym: "inositol-trisphosphate 6-kinase activity" RELATED [EC:2.7.1.134] +xref: EC:2.7.1.134 +xref: MetaCyc:2.7.1.134-RXN +xref: Reactome:R-HSA-1855162 "I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol" +xref: Reactome:R-HSA-994137 "ITPK1 converts Ins-3,4,5,6-P4 to Ins-1,3,4,5,6-P5" +xref: RHEA:12452 +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0047326 +name: inositol tetrakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] +synonym: "1D-myo-inositol-tetrakisphosphate 5-kinase activity" EXACT [] +synonym: "ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.140] +synonym: "inositol 1,3,4,6-tetrakisphosphate 5-kinase activity" EXACT [] +synonym: "inositol-tetrakisphosphate 5-kinase activity" EXACT [] +xref: EC:2.7.1.140 +xref: MetaCyc:2.7.1.140-RXN +xref: Reactome:R-HSA-1855228 "I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" +xref: RHEA:12717 +is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity + +[Term] +id: GO:0047327 +name: glycerol-3-phosphate-glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol." [EC:2.7.1.142, RHEA:21288] +synonym: "sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.142] +xref: EC:2.7.1.142 +xref: KEGG_REACTION:R00850 +xref: MetaCyc:2.7.1.142-RXN +xref: RHEA:21288 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047328 +name: acyl-phosphate-hexose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid." [EC:2.7.1.61, MetaCyc:2.7.1.61-RXN] +synonym: "acyl-phosphate:D-hexose phosphotransferase activity" RELATED [EC:2.7.1.61] +synonym: "hexose phosphate:hexose phosphotransferase activity" RELATED [EC:2.7.1.61] +xref: EC:2.7.1.61 +xref: MetaCyc:2.7.1.61-RXN +xref: RHEA:13077 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047329 +name: phosphoramidate-hexose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3." [EC:2.7.1.62, MetaCyc:2.7.1.62-RXN] +synonym: "phosphoramidate-hexose transphosphorylase activity" RELATED [EC:2.7.1.62] +synonym: "phosphoramidate:hexose 1-phosphotransferase activity" RELATED [EC:2.7.1.62] +synonym: "phosphoramidic-hexose transphosphorylase activity" RELATED [EC:2.7.1.62] +xref: EC:2.7.1.62 +xref: MetaCyc:2.7.1.62-RXN +xref: RHEA:10972 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047330 +name: polyphosphate-glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate." [EC:2.7.1.63, MetaCyc:2.7.1.63-RXN] +synonym: "polyphosphate glucokinase activity" RELATED [EC:2.7.1.63] +synonym: "polyphosphate-D-(+)-glucose-6-phosphotransferase activity" RELATED [EC:2.7.1.63] +synonym: "polyphosphate-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.63] +synonym: "polyphosphate:D-glucose 6-phosphotransferase activity" RELATED [EC:2.7.1.63] +xref: EC:2.7.1.63 +xref: MetaCyc:2.7.1.63-RXN +xref: RHEA:22036 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047331 +name: diphosphate-glycerol phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate." [EC:2.7.1.79, RHEA:13689] +synonym: "diphosphate:glycerol 1-phosphotransferase activity" RELATED [EC:2.7.1.79] +synonym: "PPi-glycerol phosphotransferase activity" RELATED [EC:2.7.1.79] +synonym: "pyrophosphate--glycerol phosphotransferase activity" RELATED [EC:2.7.1.79] +xref: EC:2.7.1.79 +xref: KEGG_REACTION:R01044 +xref: MetaCyc:2.7.1.79-RXN +xref: RHEA:13689 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047332 +name: diphosphate-serine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate." [EC:2.7.1.80, RHEA:23764] +synonym: "diphosphate:L-serine O-phosphotransferase activity" RELATED [EC:2.7.1.80] +synonym: "pyrophosphate--serine phosphotransferase activity" RELATED [EC:2.7.1.80] +synonym: "pyrophosphate-L-serine phosphotransferase activity" RELATED [EC:2.7.1.80] +xref: EC:2.7.1.80 +xref: KEGG_REACTION:R00584 +xref: MetaCyc:2.7.1.80-RXN +xref: RHEA:23764 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047333 +name: dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+)." [EC:2.7.1.88, RHEA:16281] +synonym: "ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity" RELATED [EC:2.7.1.88] +synonym: "ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity" RELATED [EC:2.7.1.88] +synonym: "dihydrostreptomycin 6-phosphate kinase (phosphorylating)" RELATED [EC:2.7.1.88] +synonym: "dihydrostreptomycin-6-phosphate 3'alpha-kinase activity" RELATED [EC:2.7.1.88] +xref: EC:2.7.1.88 +xref: KEGG_REACTION:R03395 +xref: MetaCyc:2.7.1.88-RXN +xref: RHEA:16281 +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0047334 +name: diphosphate-fructose-6-phosphate 1-phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate." [EC:2.7.1.90, MetaCyc:2.7.1.90-RXN] +synonym: "6-phosphofructokinase (diphosphate) activity" RELATED [EC:2.7.1.90] +synonym: "6-phosphofructokinase (pyrophosphate) activity" RELATED [EC:2.7.1.90] +synonym: "diphosphate-dependent 6-phosphofructose-1-kinase activity" RELATED [EC:2.7.1.90] +synonym: "diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.90] +synonym: "inorganic pyrophosphate-dependent phosphofructokinase activity" RELATED [EC:2.7.1.90] +synonym: "inorganic pyrophosphate-phosphofructokinase activity" RELATED [EC:2.7.1.90] +synonym: "pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.90] +synonym: "pyrophosphate-dependent 6-phosphofructose-1-kinase activity" RELATED [EC:2.7.1.90] +synonym: "pyrophosphate-dependent phosphofructo-1-kinase activity" RELATED [EC:2.7.1.90] +synonym: "pyrophosphate-fructose 6-phosphate phosphotransferase activity" RELATED [EC:2.7.1.90] +xref: EC:2.7.1.90 +xref: MetaCyc:2.7.1.90-RXN +xref: RHEA:13613 +is_a: GO:0008443 ! phosphofructokinase activity + +[Term] +id: GO:0047335 +name: 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate." [EC:2.7.4.17, MetaCyc:2.7.4.17-RXN] +synonym: "1,3-diphosphoglycerate-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17] +synonym: "3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17] +synonym: "diphosphoglycerate-polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.17] +xref: EC:2.7.4.17 +xref: MetaCyc:2.7.4.17-RXN +xref: RHEA:18665 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047336 +name: 5-methyldeoxycytidine-5'-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+)." [EC:2.7.4.19, RHEA:11396] +synonym: "ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity" RELATED [EC:2.7.4.19] +xref: EC:2.7.4.19 +xref: KEGG_REACTION:R04235 +xref: MetaCyc:2.7.4.19-RXN +xref: RHEA:11396 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047337 +name: dolichyl-diphosphate-polyphosphate phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate." [EC:2.7.4.20, MetaCyc:2.7.4.20-RXN] +synonym: "dolichyl-diphosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.20] +synonym: "dolichylpyrophosphate:polyphosphate phosphotransferase activity" RELATED [EC:2.7.4.20] +xref: EC:2.7.4.20 +xref: MetaCyc:2.7.4.20-RXN +xref: RHEA:19417 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047338 +name: UTP:xylose-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate." [EC:2.7.7.11, MetaCyc:2.7.7.11-RXN] +synonym: "UDP-xylose pyrophosphorylase activity" RELATED [EC:2.7.7.11] +synonym: "uridine diphosphoxylose pyrophosphorylase activity" RELATED [EC:2.7.7.11] +synonym: "uridylyltransferase, xylose 1-phosphate" RELATED [EC:2.7.7.11] +synonym: "UTP-xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11] +synonym: "UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11] +synonym: "xylose 1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11] +synonym: "xylose-1-phosphate uridylyltransferase activity" RELATED [EC:2.7.7.11] +xref: EC:2.7.7.11 +xref: MetaCyc:2.7.7.11-RXN +xref: RHEA:18389 +is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity + +[Term] +id: GO:0047339 +name: nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity +namespace: molecular_function +alt_id: GO:0047340 +def: "Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate." [EC:2.7.7.28, MetaCyc:2.7.7.28-RXN] +synonym: "GDP hexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] +synonym: "GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity" NARROW [EC:2.7.7.28] +synonym: "GTP:hexose-1-phosphate guanylyltransferase activity" NARROW [] +synonym: "guanosine diphosphohexose pyrophosphorylase activity" NARROW [EC:2.7.7.28] +synonym: "hexose 1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.28] +synonym: "hexose 1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28] +synonym: "hexose nucleotidylating enzyme activity" RELATED [EC:2.7.7.28] +synonym: "hexose-1-phosphate guanylyltransferase activity" NARROW [] +synonym: "NDP hexose pyrophosphorylase activity" RELATED [EC:2.7.7.28] +synonym: "NDP-hexose diphosphorylase activity" EXACT [] +synonym: "NDP-hexose pyrophosphorylase activity" EXACT [] +synonym: "NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28] +synonym: "NTP:hexose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28] +synonym: "nucleoside diphosphohexose pyrophosphorylase activity" RELATED [EC:2.7.7.28] +synonym: "nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.28] +xref: EC:2.7.7.28 +xref: MetaCyc:2.7.7.28-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047341 +name: fucose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose." [EC:2.7.7.30, RHEA:13549] +synonym: "GDP fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30] +synonym: "GDP-fucose diphosphorylase activity" RELATED [EC:2.7.7.30] +synonym: "GDP-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30] +synonym: "GDP-L-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30] +synonym: "GTP:beta-L-fucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.30] +synonym: "GTP:fucose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "GTP:L-fucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.30] +synonym: "guanosine diphosphate L-fucose pyrophosphorylase activity" RELATED [EC:2.7.7.30] +xref: EC:2.7.7.30 +xref: KEGG_REACTION:R01951 +xref: MetaCyc:2.7.7.30-RXN +xref: Reactome:R-HSA-6787533 "FPGT transfers guanylyl group from GTP to Fuc1P to form GDP-Fuc" +xref: RHEA:13549 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0047342 +name: galactose-1-phosphate thymidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose." [EC:2.7.7.32, RHEA:17165] +synonym: "dTDP galactose pyrophosphorylase activity" RELATED [EC:2.7.7.32] +synonym: "dTDP-galactose diphosphorylase activity" RELATED [EC:2.7.7.32] +synonym: "dTDP-galactose pyrophosphorylase activity" RELATED [EC:2.7.7.32] +synonym: "dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.32] +synonym: "galactose 1-phosphate thymidylyl transferase activity" RELATED [EC:2.7.7.32] +synonym: "thymidine diphosphogalactose pyrophosphorylase activity" RELATED [EC:2.7.7.32] +synonym: "thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity" RELATED [EC:2.7.7.32] +xref: EC:2.7.7.32 +xref: KEGG_REACTION:R02329 +xref: MetaCyc:2.7.7.32-RXN +xref: RHEA:17165 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047343 +name: glucose-1-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate." [EC:2.7.7.33, RHEA:18213] +synonym: "CDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33] +synonym: "CDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.33] +synonym: "CDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33] +synonym: "CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.33] +synonym: "CTP:D-glucose-1-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.33] +synonym: "CTP:glucose-1-phosphate cytidylyltransferase activity" EXACT [] +synonym: "cytidine diphosphate glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33] +synonym: "cytidine diphosphate-D-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.33] +synonym: "cytidine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.33] +xref: EC:2.7.7.33 +xref: KEGG_REACTION:R00956 +xref: MetaCyc:2.7.7.33-RXN +xref: RHEA:18213 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0047344 +name: glucose-1-phosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose." [EC:2.7.7.34, RHEA:10708] +synonym: "GDP glucose pyrophosphorylase activity" RELATED [EC:2.7.7.34] +synonym: "GDP-glucose diphosphorylase activity" RELATED [EC:2.7.7.34] +synonym: "GDP-glucose pyrophosphorylase activity" RELATED [EC:2.7.7.34] +synonym: "GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity" RELATED [EC:2.7.7.34] +synonym: "GTP:glucose-1-phosphate guanylyltransferase activity" EXACT [] +synonym: "guanosine diphosphoglucose pyrophosphorylase activity" RELATED [EC:2.7.7.34] +xref: EC:2.7.7.34 +xref: KEGG_REACTION:R00954 +xref: MetaCyc:2.7.7.34-RXN +xref: RHEA:10708 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0047345 +name: ribose-5-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate." [EC:2.7.7.35, RHEA:14529] +synonym: "adenosine diphosphoribose phosphorylase activity" RELATED [EC:2.7.7.35] +synonym: "ADP ribose phosphorylase activity" RELATED [EC:2.7.7.35] +synonym: "ADP-ribose phosphorylase activity" RELATED [EC:2.7.7.35] +synonym: "ADP:D-ribose-5-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.35] +synonym: "ADP:ribose-5-phosphate adenylyltransferase activity" EXACT [] +xref: EC:2.7.7.35 +xref: KEGG_REACTION:R01052 +xref: MetaCyc:2.7.7.35-RXN +xref: RHEA:14529 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0047346 +name: aldose-1-phosphate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose." [EC:2.7.7.36, MetaCyc:2.7.7.36-RXN] +synonym: "adenosine diphosphate glucose:orthophosphate adenylyltransferase activity" RELATED [EC:2.7.7.36] +synonym: "adenosine diphosphosugar phosphorylase activity" RELATED [EC:2.7.7.36] +synonym: "ADP sugar phosphorylase activity" RELATED [EC:2.7.7.36] +synonym: "ADP-aldose phosphorylase activity" RELATED [EC:2.7.7.36] +synonym: "ADP-sugar phosphorylase activity" BROAD [EC:2.7.7.36] +synonym: "ADP:aldose-1-phosphate adenylyltransferase activity" EXACT [] +synonym: "ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity" RELATED [EC:2.7.7.36] +synonym: "ADPaldose phosphorylase activity" RELATED [EC:2.7.7.36] +synonym: "sugar-1-phosphate adenylyltransferase activity" BROAD [EC:2.7.7.36] +xref: EC:2.7.7.36 +xref: MetaCyc:2.7.7.36-RXN +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0047347 +name: aldose-1-phosphate nucleotidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose." [EC:2.7.7.37, MetaCyc:2.7.7.37-RXN] +synonym: "glucose 1-phosphate inosityltransferase activity" RELATED [EC:2.7.7.37] +synonym: "NDP sugar phosphorylase activity" RELATED [EC:2.7.7.37] +synonym: "NDP-aldose phosphorylase activity" RELATED [EC:2.7.7.37] +synonym: "NDP-sugar phosphorylase activity" BROAD [EC:2.7.7.37] +synonym: "NDP:aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37] +synonym: "NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37] +synonym: "NDPaldose phosphorylase activity" RELATED [EC:2.7.7.37] +synonym: "nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37] +synonym: "nucleoside diphosphosugar phosphorylase activity" RELATED [EC:2.7.7.37] +synonym: "sugar nucleotide phosphorylase activity" RELATED [EC:2.7.7.37] +synonym: "sugar phosphate nucleotidyltransferase activity" RELATED [EC:2.7.7.37] +synonym: "sugar-1-phosphate nucleotidyltransferase activity" BROAD [EC:2.7.7.37] +xref: EC:2.7.7.37 +xref: MetaCyc:2.7.7.37-RXN +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0047348 +name: glycerol-3-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate." [EC:2.7.7.39, RHEA:13361] +synonym: "CDP-glycerol diphosphorylase activity" RELATED [EC:2.7.7.39] +synonym: "CDP-glycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39] +synonym: "CTP:glycerol 3-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.39] +synonym: "CTP:glycerol-3-phosphate cytidylyltransferase activity" EXACT [] +synonym: "CTP:sn-glycerol-3-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.39] +synonym: "cytidine diphosphate glycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39] +synonym: "cytidine diphosphoglycerol pyrophosphorylase activity" RELATED [EC:2.7.7.39] +synonym: "Gro-PCT" RELATED [EC:2.7.7.39] +xref: EC:2.7.7.39 +xref: KEGG_REACTION:R00856 +xref: MetaCyc:2.7.7.39-RXN +xref: RHEA:13361 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0047349 +name: D-ribitol-5-phosphate cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate." [EC:2.7.7.40, RHEA:12456] +synonym: "CDP ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40] +synonym: "CDP-ribitol diphosphorylase activity" RELATED [EC:2.7.7.40] +synonym: "CDP-ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40] +synonym: "CTP:D-ribitol-5-phosphate cytidylyltransferase activity" EXACT [] +synonym: "cytidine diphosphate ribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40] +synonym: "cytidine diphosphoribitol pyrophosphorylase activity" RELATED [EC:2.7.7.40] +synonym: "ribitol 5-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.40] +xref: EC:2.7.7.40 +xref: KEGG_REACTION:R02921 +xref: MetaCyc:2.7.7.40-RXN +xref: RHEA:12456 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0047350 +name: glucuronate-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate." [EC:2.7.7.44, RHEA:16325] +synonym: "UDP-D-glucuronic acid pyrophosphorylase activity" RELATED [EC:2.7.7.44] +synonym: "UDP-glucuronate pyrophosphorylase activity" RELATED [EC:2.7.7.44] +synonym: "UDP-glucuronic acid pyrophosphorylase activity" RELATED [EC:2.7.7.44] +synonym: "uridine diphosphoglucuronic pyrophosphorylase activity" RELATED [EC:2.7.7.44] +synonym: "UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity" RELATED [EC:2.7.7.44] +synonym: "UTP:glucuronate-1-phosphate uridylyltransferase activity" EXACT [] +xref: EC:2.7.7.44 +xref: KEGG_REACTION:R01381 +xref: MetaCyc:2.7.7.44-RXN +xref: RHEA:16325 +is_a: GO:0070569 ! uridylyltransferase activity + +[Term] +id: GO:0047351 +name: guanosine-triphosphate guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+)." [EC:2.7.7.45, RHEA:18153] +synonym: "GTP:GTP guanylyltransferase activity" BROAD [] +xref: EC:2.7.7.45 +xref: KEGG_REACTION:R00012 +xref: MetaCyc:2.7.7.45-RXN +xref: RHEA:18153 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0047352 +name: adenylylsulfate-ammonia adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate." [EC:2.7.7.51, RHEA:19197] +synonym: "adenylylsulfate:ammonia adenylyltransferase activity" RELATED [EC:2.7.7.51] +synonym: "adenylylsulphate-ammonia adenylyltransferase activity" EXACT [] +synonym: "APSAT" RELATED [EC:2.7.7.51] +xref: EC:2.7.7.51 +xref: KEGG_REACTION:R01619 +xref: MetaCyc:2.7.7.51-RXN +xref: RHEA:19197 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0047353 +name: N-methylphosphoethanolamine cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate." [EC:2.7.7.57, RHEA:10576] +synonym: "CTP:N-methylethanolamine-phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.57] +synonym: "CTP:N-methylphosphoethanolamine cytidylyltransferase activity" EXACT [] +synonym: "CTP:P-MEA cytidylyltransferase activity" RELATED [EC:2.7.7.57] +synonym: "monomethylethanolamine phosphate cytidylyltransferase activity" RELATED [EC:2.7.7.57] +xref: EC:2.7.7.57 +xref: KEGG_REACTION:R03375 +xref: MetaCyc:2.7.7.57-RXN +xref: RHEA:10576 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0047354 +name: sphingosine cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine." [EC:2.7.8.10, RHEA:21224] +synonym: "CDP-choline-sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10] +synonym: "CDP-choline:sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10] +synonym: "cytidine diphosphocholine-sphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.10] +synonym: "phosphorylcholine-sphingosine transferase activity" RELATED [EC:2.7.8.10] +synonym: "sphingosine choline phosphotransferase activity" EXACT [] +xref: EC:2.7.8.10 +xref: KEGG_REACTION:R01929 +xref: MetaCyc:2.7.8.10-RXN +xref: RHEA:21224 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047355 +name: CDP-glycerol glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP." [EC:2.7.8.12, MetaCyc:2.7.8.12-RXN] +synonym: "CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity" RELATED [EC:2.7.8.12] +synonym: "CDPglycerol glycerophosphotransferase activity" RELATED [EC:2.7.8.12] +synonym: "CGPTase activity" RELATED [EC:2.7.8.12] +synonym: "cytidine diphosphoglycerol glycerophosphotransferase activity" RELATED [EC:2.7.8.12] +synonym: "glycerophosphate synthetase activity" RELATED [EC:2.7.8.12] +synonym: "poly(glycerol phosphate) polymerase activity" RELATED [EC:2.7.8.12] +synonym: "teichoic acid glycerol transferase activity" RELATED [EC:2.7.8.12] +synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.12] +xref: EC:2.7.8.12 +xref: MetaCyc:2.7.8.12-RXN +xref: RHEA:13565 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047356 +name: CDP-ribitol ribitolphosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP." [EC:2.7.8.14, MetaCyc:2.7.8.14-RXN] +synonym: "CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity" RELATED [EC:2.7.8.14] +synonym: "CDPribitol ribitolphosphotransferase activity" RELATED [EC:2.7.8.14] +synonym: "poly(ribitol phosphate) synthetase activity" RELATED [EC:2.7.8.14] +synonym: "polyribitol phosphate polymerase activity" RELATED [EC:2.7.8.14] +synonym: "polyribitol phosphate synthetase activity" RELATED [EC:2.7.8.14] +synonym: "teichoate synthase activity" RELATED [EC:2.7.8.14] +synonym: "teichoate synthetase activity" RELATED [EC:2.7.8.14] +synonym: "teichoic-acid synthase activity" BROAD [EC:2.7.8.14] +xref: EC:2.7.8.14 +xref: MetaCyc:2.7.8.14-RXN +xref: RHEA:13353 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047357 +name: UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP." [EC:2.7.8.18, RHEA:22440] +synonym: "galactose-1-phosphotransferase activity" RELATED [EC:2.7.8.18] +synonym: "galactosyl phosphotransferase activity" RELATED [EC:2.7.8.18] +synonym: "UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18] +synonym: "UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18] +synonym: "UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity" RELATED [EC:2.7.8.18] +synonym: "uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity" RELATED [EC:2.7.8.18] +xref: EC:2.7.8.18 +xref: KEGG_REACTION:R00504 +xref: MetaCyc:2.7.8.18-RXN +xref: RHEA:22440 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047358 +name: UDP-glucose-glycoprotein glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP." [EC:2.7.8.19, MetaCyc:2.7.8.19-RXN] +synonym: "Glc-phosphotransferase activity" RELATED [EC:2.7.8.19] +synonym: "GlcPTase activity" RELATED [EC:2.7.8.19] +synonym: "UDP-glucose:glycoprotein glucose-1-phosphotransferase activity" RELATED [EC:2.7.8.19] +synonym: "UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity" RELATED [EC:2.7.8.19] +synonym: "UDPglucose-glycoprotein glucose phosphotransferase activity" RELATED [EC:2.7.8.19] +synonym: "UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity" RELATED [EC:2.7.8.19] +synonym: "uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity" RELATED [EC:2.7.8.19] +xref: EC:2.7.8.19 +xref: MetaCyc:2.7.8.19-RXN +xref: RHEA:20181 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047359 +name: 1-alkenyl-2-acylglycerol choline phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP." [EC:2.7.8.22, MetaCyc:2.7.8.22-RXN] +synonym: "CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity" RELATED [EC:2.7.8.22] +synonym: "CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity" RELATED [EC:2.7.8.22] +xref: EC:2.7.8.22 +xref: MetaCyc:2.7.8.22-RXN +xref: RHEA:36227 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047360 +name: undecaprenyl-phosphate galactose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP." [EC:2.7.8.6, RHEA:11652] +synonym: "poly(isoprenol)-phosphate galactose phosphotransferase activity" RELATED [EC:2.7.8.6] +synonym: "poly(isoprenol)-phosphate galactosephosphotransferase activity" RELATED [EC:2.7.8.6] +synonym: "poly(isoprenyl)phosphate galactosephosphatetransferase activity" RELATED [EC:2.7.8.6] +synonym: "UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity" RELATED [EC:2.7.8.6] +synonym: "undecaprenyl phosphate galactosyl-1-phosphate transferase activity" RELATED [EC:2.7.8.6] +xref: EC:2.7.8.6 +xref: KEGG_REACTION:R01535 +xref: MetaCyc:2.7.8.6-RXN +xref: RHEA:11652 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047361 +name: phosphomannan mannosephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP." [EC:2.7.8.9, MetaCyc:2.7.8.9-RXN] +synonym: "GDP-mannose:phosphomannan mannose phosphotransferase activity" RELATED [EC:2.7.8.9] +xref: EC:2.7.8.9 +xref: MetaCyc:2.7.8.9-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047362 +name: thiosulfate-dithiol sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite." [EC:2.8.1.5, MetaCyc:2.8.1.5-RXN] +synonym: "thiosulfate reductase activity" RELATED [EC:2.8.1.5] +synonym: "thiosulfate:dithioerythritol sulfurtransferase activity" RELATED [EC:2.8.1.5] +synonym: "thiosulphate-dithiol sulphurtransferase activity" EXACT [] +synonym: "TSR" RELATED [EC:2.8.1.5] +xref: EC:2.8.1.5 +xref: MetaCyc:2.8.1.5-RXN +xref: RHEA:15121 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0047363 +name: triglucosylalkylacylglycerol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate." [EC:2.8.2.19, MetaCyc:2.8.2.19-RXN] +synonym: "3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity" RELATED [EC:2.8.2.19] +synonym: "triglucosylalkylacylglycerol sulphotransferase activity" EXACT [] +synonym: "triglucosylmonoalkylmonoacyl sulfotransferase activity" RELATED [EC:2.8.2.19] +xref: EC:2.8.2.19 +xref: MetaCyc:2.8.2.19-RXN +xref: RHEA:13273 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047364 +name: desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+)." [EC:2.8.2.24, RHEA:20281] +synonym: "3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24] +synonym: "3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24] +synonym: "desulphoglucosinolate sulphotransferase activity" EXACT [] +synonym: "PAPS-desulfoglucosinolate sulfotransferase activity" RELATED [EC:2.8.2.24] +xref: EC:2.8.2.24 +xref: KEGG_REACTION:R03214 +xref: MetaCyc:2.8.2.24-RXN +xref: RHEA:20281 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047365 +name: quercetin-3-sulfate 3'-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate." [EC:2.8.2.26, RHEA:22504] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity" RELATED [EC:2.8.2.26] +synonym: "3'-sulfotransferase activity" RELATED [EC:2.8.2.26] +synonym: "flavonol 3'-sulfotransferase activity" RELATED [EC:2.8.2.26] +synonym: "PAPS:flavonol 3-sulfate 3'-sulfotransferase activity" RELATED [EC:2.8.2.26] +synonym: "quercetin-3-sulphate 3'-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.26 +xref: KEGG_REACTION:R02632 +xref: MetaCyc:2.8.2.26-RXN +xref: RHEA:22504 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047366 +name: quercetin-3-sulfate 4'-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate." [EC:2.8.2.27, RHEA:17205] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity" RELATED [EC:2.8.2.27] +synonym: "flavonol 4'-sulfotransferase activity" RELATED [EC:2.8.2.27] +synonym: "PAPS:flavonol 3-sulfate 4'-sulfotransferase activity" RELATED [EC:2.8.2.27] +synonym: "quercetin-3-sulphate 4'-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.27 +xref: KEGG_REACTION:R02633 +xref: MetaCyc:2.8.2.27-RXN +xref: RHEA:17205 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047367 +name: quercetin-3,3'-bissulfate 7-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate." [EC:2.8.2.28, MetaCyc:2.8.2.28-RXN] +synonym: "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity" RELATED [EC:2.8.2.28] +synonym: "7-sulfotransferase activity" RELATED [EC:2.8.2.28] +synonym: "flavonol 7-sulfotransferase activity" RELATED [EC:2.8.2.28] +synonym: "PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity" RELATED [EC:2.8.2.28] +synonym: "quercetin-3,3'-bissulphate 7-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.28 +xref: MetaCyc:2.8.2.28-RXN +xref: RHEA:21860 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047368 +name: UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate." [EC:2.8.2.7, RHEA:14337] +synonym: "3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity" RELATED [EC:2.8.2.7] +synonym: "UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity" EXACT [] +synonym: "uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity" RELATED [EC:2.8.2.7] +synonym: "uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity" RELATED [EC:2.8.2.7] +xref: EC:2.8.2.7 +xref: KEGG_REACTION:R04476 +xref: MetaCyc:2.8.2.7-RXN +xref: RHEA:14337 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047369 +name: succinate-hydroxymethylglutarate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate." [EC:2.8.3.13, MetaCyc:2.8.3.13-RXN] +synonym: "dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity" RELATED [EC:2.8.3.13] +synonym: "hydroxymethylglutarate coenzyme A-transferase activity" RELATED [EC:2.8.3.13] +synonym: "succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity" RELATED [EC:2.8.3.13] +xref: EC:2.8.3.13 +xref: MetaCyc:2.8.3.13-RXN +xref: RHEA:12284 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047370 +name: succinate-citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." [PMID:16547052, RHEA:38287] +synonym: "citramalate coenzyme A-transferase activity" EXACT [] +synonym: "itaconate CoA-transferase activity" EXACT [] +synonym: "succinyl coenzyme A-citramalyl coenzyme A transferase activity" EXACT [] +synonym: "succinyl-CoA:citramalate CoA-transferase activity" EXACT [] +xref: MetaCyc:2.8.3.7-RXN +xref: RHEA:38287 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047371 +name: butyrate-acetoacetate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate." [EC:2.8.3.9, RHEA:12961] +synonym: "butanoyl-CoA:acetoacetate CoA-transferase activity" RELATED [EC:2.8.3.9] +synonym: "butyryl coenzyme A-acetoacetate coenzyme A-transferase activity" RELATED [EC:2.8.3.9] +synonym: "butyryl-CoA-acetoacetate CoA-transferase activity" RELATED [EC:2.8.3.9] +xref: EC:2.8.3.9 +xref: KEGG_REACTION:R01365 +xref: MetaCyc:2.8.3.9-RXN +xref: RHEA:12961 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047372 +name: acylglycerol lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] +subset: goslim_chembl +synonym: "fatty acyl monoester lipase activity" RELATED [EC:3.1.1.23] +synonym: "glycerol-ester acylhydrolase activity" RELATED [EC:3.1.1.23] +synonym: "monoacylglycerol hydrolase activity" RELATED [EC:3.1.1.23] +synonym: "monoacylglycerol lipase activity" RELATED [EC:3.1.1.23] +synonym: "monoacylglycerolipase activity" RELATED [EC:3.1.1.23] +synonym: "monoglyceridase activity" RELATED [EC:3.1.1.23] +synonym: "monoglyceride hydrolase activity" RELATED [EC:3.1.1.23] +synonym: "monoglyceride lipase activity" RELATED [EC:3.1.1.23] +synonym: "monoglyceridyllipase activity" RELATED [EC:3.1.1.23] +xref: EC:3.1.1.23 +xref: MetaCyc:3.1.1.23-RXN +xref: Reactome:R-HSA-1482543 "2-MAG is hydrolyzed to fatty acid and glycerol by MGLL" +xref: Reactome:R-HSA-163595 "2-acylglycerol + H2O -> glycerol + fatty acid" +xref: Reactome:R-HSA-192422 "Digestion of triacylglycerols by extracellular PTL:colipase" +xref: Reactome:R-HSA-192425 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase)" +xref: Reactome:R-HSA-192430 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase)" +xref: Reactome:R-HSA-192434 "Digestion of diacylglycerols by extracellular PTL:colipase" +xref: Reactome:R-HSA-192475 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2" +xref: Reactome:R-HSA-426032 "DAG is metabolized by DAGL to 2-AG" +xref: Reactome:R-HSA-426043 "2-AG hydrolysis to arachidonate by MAGL" +xref: Reactome:R-HSA-5694462 "ABHD6,12 hydrolyse 3AG" +xref: RHEA:34019 +is_a: GO:0016298 ! lipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047373 +name: acetoxybutynylbithiophene deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.54, RHEA:11548] +synonym: "5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity" RELATED [EC:3.1.1.54] +synonym: "5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity" RELATED [EC:3.1.1.54] +synonym: "acetoxybutynylbithiophene esterase activity" RELATED [EC:3.1.1.54] +xref: EC:3.1.1.54 +xref: KEGG_REACTION:R04490 +xref: MetaCyc:3.1.1.54-RXN +xref: RHEA:11548 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047374 +name: methylumbelliferyl-acetate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+)." [EC:3.1.1.56, RHEA:12208] +synonym: "4-methylumbelliferyl-acetate acylhydrolase activity" RELATED [EC:3.1.1.56] +synonym: "esterase D activity" RELATED [EC:3.1.1.56] +xref: EC:3.1.1.56 +xref: KEGG_REACTION:R04141 +xref: MetaCyc:3.1.1.56-RXN +xref: RHEA:12208 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047375 +name: N-acetylgalactosaminoglycan deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan." [EC:3.1.1.58, MetaCyc:3.1.1.58-RXN] +synonym: "N-acetyl galactosaminoglycan deacetylase activity" RELATED [EC:3.1.1.58] +synonym: "N-acetyl-D-galactosaminoglycan acetylhydrolase activity" RELATED [EC:3.1.1.58] +synonym: "polysaccharide deacetylase activity" RELATED [EC:3.1.1.58] +synonym: "Vi-polysaccharide deacetylase activity" RELATED [EC:3.1.1.58] +xref: EC:3.1.1.58 +xref: MetaCyc:3.1.1.58-RXN +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047376 +name: all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate." [RHEA:13933] +synonym: "all-trans-retinyl-palmitate acylhydrolase activity" BROAD [EC:3.1.1.64] +synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64] +synonym: "retinyl-palmitate palmitohydrolase activity" BROAD [KEGG_REACTION:R02368] +xref: KEGG_REACTION:R02368 +xref: MetaCyc:3.1.1.64-RXN +xref: Reactome:R-HSA-2404140 "NREH hydrolyses atREs to atROL and FAs" +xref: Reactome:R-HSA-2429643 "NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs" +xref: RHEA:13933 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047377 +name: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)." [EC:3.1.1.66, RHEA:16313] +synonym: "3,4-diacetoxybutinylbithiophene:4-acetate esterase activity" RELATED [EC:3.1.1.66] +synonym: "5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity" RELATED [EC:3.1.1.66] +synonym: "diacetoxybutynylbithiophene acetate esterase activity" RELATED [EC:3.1.1.66] +xref: EC:3.1.1.66 +xref: KEGG_REACTION:R04525 +xref: MetaCyc:3.1.1.66-RXN +xref: RHEA:16313 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047378 +name: acetylalkylglycerol acetylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+)." [EC:3.1.1.71, RHEA:11552] +synonym: "2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity" RELATED [EC:3.1.1.71] +synonym: "alkylacetylglycerol acetylhydrolase activity" RELATED [EC:3.1.1.71] +xref: EC:3.1.1.71 +xref: KEGG_REACTION:R04043 +xref: MetaCyc:3.1.1.71-RXN +xref: RHEA:11552 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047379 +name: ADP-dependent short-chain-acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA." [EC:3.1.2.18, MetaCyc:3.1.2.18-RXN] +synonym: "ADP-dependent propionyl coenzyme A hydrolase activity" NARROW [EC:3.1.2.18] +synonym: "ADP-dependent propionyl-CoA hydrolase activity" NARROW [EC:3.1.2.18] +synonym: "ADP-dependent propionyl-CoA thioesterase activity" NARROW [EC:3.1.2.18] +synonym: "ADP-dependent short-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.18] +synonym: "ADP-dependent short-chain acyl-CoA hydrolase activity" RELATED [EC:3.1.2.18] +synonym: "ADP-dependent short-chain acyl-CoA thioesterase activity" RELATED [EC:3.1.2.18] +synonym: "ADP-dependent-short-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.18] +xref: EC:3.1.2.18 +xref: MetaCyc:3.1.2.18-RXN +is_a: GO:0047617 ! acyl-CoA hydrolase activity + +[Term] +id: GO:0047380 +name: ADP-dependent medium-chain-acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP." [EC:3.1.2.19, MetaCyc:3.1.2.19-RXN] +synonym: "ADP-dependent medium-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "ADP-dependent medium-chain acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "ADP-dependent medium-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "ADP-dependent medium-chain hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "ADP-dependent myristoyl-CoA thioesterase activity" NARROW [EC:3.1.2.19] +synonym: "ADP-dependent-medium-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] +xref: EC:3.1.2.19 +xref: MetaCyc:3.1.2.19-RXN +is_a: GO:0052815 ! medium-chain acyl-CoA hydrolase activity + +[Term] +id: GO:0047381 +name: dodecanoyl-[acyl-carrier-protein] hydrolase activity +namespace: molecular_function +alt_id: GO:0016294 +def: "Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]." [EC:3.1.2.21, MetaCyc:3.1.2.21-RXN] +synonym: "dodecanoyl-[acyl-carrier protein] hydrolase activity" EXACT [] +synonym: "dodecanoyl-ACP hydrolase activity" EXACT [] +synonym: "dodecanoyl-acyl-carrier-protein hydrolase activity" RELATED [EC:3.1.2.21] +synonym: "dodecyl-[acyl-carrier protein] hydrolase activity" RELATED [EC:3.1.2.21] +synonym: "dodecyl-acyl-carrier protein hydrolase" BROAD [EC:3.1.2.21] +synonym: "lauroyl-[acyl-carrier-protein] hydrolase activity" EXACT [] +synonym: "lauroyl-ACP hydrolase activity" EXACT [] +synonym: "lauryl-[acyl-carrier protein] hydrolase activity" RELATED [EC:3.1.2.21] +synonym: "lauryl-acyl-carrier protein hydrolase activity" RELATED [EC:3.1.2.21] +synonym: "lauryl-acyl-carrier-protein hydrolase activity" RELATED [EC:3.1.2.21] +xref: EC:3.1.2.21 +xref: MetaCyc:3.1.2.21-RXN +xref: RHEA:30119 +is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity + +[Term] +id: GO:0047382 +name: methylphosphothioglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate." [EC:3.1.3.14, RHEA:16081] +synonym: "methylthiophosphoglycerate phosphatase activity" RELATED [EC:3.1.3.14] +synonym: "S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity" RELATED [EC:3.1.3.14] +xref: EC:3.1.3.14 +xref: KEGG_REACTION:R04317 +xref: MetaCyc:3.1.3.14-RXN +xref: RHEA:16081 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047383 +name: guanidinodeoxy-scyllo-inositol-4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate." [EC:3.1.3.40, RHEA:15777] +synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity" RELATED [EC:3.1.3.40] +synonym: "1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity" RELATED [EC:3.1.3.40] +synonym: "1-guanidino-scyllo-inositol 4-phosphatase activity" RELATED [EC:3.1.3.40] +xref: EC:3.1.3.40 +xref: KEGG_REACTION:R03496 +xref: MetaCyc:3.1.3.40-RXN +xref: RHEA:15777 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047384 +name: [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]." [EC:3.1.3.47, MetaCyc:3.1.3.47-RXN] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity" RELATED [EC:3.1.3.47] +synonym: "hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.47] +synonym: "reductase phosphatase activity" BROAD [EC:3.1.3.47] +xref: EC:3.1.3.47 +xref: MetaCyc:3.1.3.47-RXN +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0047385 +name: [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]." [EC:3.1.3.52, MetaCyc:3.1.3.52-RXN] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity" RELATED [EC:3.1.3.52] +synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.52] +synonym: "branched-chain 2-keto acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] +synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" BROAD [EC:3.1.3.52] +synonym: "branched-chain oxo-acid dehydrogenase phosphatase activity" RELATED [EC:3.1.3.52] +xref: EC:3.1.3.52 +xref: MetaCyc:3.1.3.52-RXN +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0047386 +name: fructose-2,6-bisphosphate 6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate." [EC:3.1.3.54, RHEA:13333] +synonym: "beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54] +synonym: "D-fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54] +synonym: "fructose 2,6-bisphosphate-6-phosphohydrolase activity" RELATED [EC:3.1.3.54] +synonym: "fructose-2,6-bisphosphate 6-phosphohydrolase activity" RELATED [EC:3.1.3.54] +xref: EC:3.1.3.54 +xref: KEGG_REACTION:R02730 +xref: MetaCyc:3.1.3.54-RXN +xref: RHEA:13333 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0047387 +name: serine-ethanolaminephosphate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine." [EC:3.1.4.13, RHEA:17113] +synonym: "SEP diesterase activity" RELATED [EC:3.1.4.13] +synonym: "serine ethanolamine phosphodiester phosphodiesterase activity" RELATED [EC:3.1.4.13] +synonym: "serine-phosphoethanolamine ethanolaminephosphohydrolase activity" RELATED [EC:3.1.4.13] +xref: EC:3.1.4.13 +xref: KEGG_REACTION:R02817 +xref: MetaCyc:3.1.4.13-RXN +xref: RHEA:17113 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047388 +name: [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase +namespace: molecular_function +def: "Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]." [MetaCyc:3.1.4.15-RXN] +comment: Formerly EC:3.1.4.15. +synonym: "adenylyl(glutamine synthetase) hydrolase activity" EXACT [] +synonym: "adenylyl-[glutamate-ammonia ligase] hydrolase activity" EXACT [] +synonym: "adenylyl-glutamate-ammonia ligase hydrolase activity" EXACT [] +synonym: "adenylyl-glutamine-synthetasehydrolase activity" EXACT [] +synonym: "adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity" EXACT [] +xref: EC:2.7.7.89 +xref: KEGG_REACTION:R03474 +xref: MetaCyc:3.1.4.15-RXN +xref: RHEA:43716 +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0047389 +name: glycerophosphocholine phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline." [EC:3.1.4.2, MetaCyc:3.1.4.2-RXN] +synonym: "glycerolphosphorylcholine phosphodiesterase activity" RELATED [EC:3.1.4.2] +synonym: "glycerophosphinicocholine diesterase activity" RELATED [EC:3.1.4.2] +synonym: "glycerophosphohydrolase activity" RELATED [EC:3.1.4.2] +synonym: "glycerylphosphorylcholinediesterase activity" RELATED [EC:3.1.4.2] +synonym: "sn-glycero-3-phosphocholine glycerophosphohydrolase activity" RELATED [EC:3.1.4.2] +synonym: "sn-glycero-3-phosphorylcholine diesterase activity" RELATED [EC:3.1.4.2] +xref: EC:3.1.4.2 +xref: MetaCyc:3.1.4.2-RXN +xref: Reactome:R-HSA-6814132 "GDPD5 hydrolyzes GPCho" +xref: RHEA:16061 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047390 +name: glycerophosphocholine cholinephosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+)." [EC:3.1.4.38, RHEA:19545] +synonym: "L-3-glycerylphosphinicocholine cholinephosphohydrolase activity" RELATED [EC:3.1.4.38] +synonym: "sn-glycero-3-phosphocholine cholinephosphohydrolase activity" RELATED [EC:3.1.4.38] +xref: EC:3.1.4.38 +xref: KEGG_REACTION:R02591 +xref: MetaCyc:3.1.4.38-RXN +xref: Reactome:R-HSA-6814797 "ENPP6 hydrolyzes lysophosphatidylcholine" +xref: RHEA:19545 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047391 +name: alkylglycerophosphoethanolamine phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate." [EC:3.1.4.39, MetaCyc:3.1.4.39-RXN] +synonym: "1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity" RELATED [EC:3.1.4.39] +synonym: "lysophospholipase D activity" RELATED [EC:3.1.4.39] +xref: EC:3.1.4.39 +xref: MetaCyc:3.1.4.39-RXN +xref: RHEA:15965 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047392 +name: CMP-N-acylneuraminate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP." [EC:3.1.4.40, MetaCyc:3.1.4.40-RXN] +synonym: "CMP-N-acetylneuraminate hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "CMP-N-acylneuraminate N-acylneuraminohydrolase activity" RELATED [EC:3.1.4.40] +synonym: "CMP-N-acylneuraminic acid hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "CMP-sialate hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "CMP-sialic acid hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "cytidine monophosphate-N-acetylneuraminic acid hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "cytidine monophosphosialate hydrolase activity" RELATED [EC:3.1.4.40] +synonym: "cytidine monophosphosialic hydrolase activity" RELATED [EC:3.1.4.40] +xref: EC:3.1.4.40 +xref: MetaCyc:3.1.4.40-RXN +xref: RHEA:20185 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047393 +name: glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+)." [EC:3.1.4.42, RHEA:16493] +synonym: "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity" RELATED [EC:3.1.4.42] +synonym: "rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity" RELATED [EC:3.1.4.42] +xref: EC:3.1.4.42 +xref: KEGG_REACTION:R02648 +xref: MetaCyc:3.1.4.42-RXN +xref: RHEA:16493 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047394 +name: glycerophosphoinositol inositolphosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol." [EC:3.1.4.43, MetaCyc:3.1.4.43-RXN] +synonym: "1,2-cyclic-inositol-phosphate phosphodiesterase activity" EXACT [] +synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity" RELATED [EC:3.1.4.43] +synonym: "1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" RELATED [EC:3.1.4.43] +synonym: "D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43] +synonym: "D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43] +synonym: "D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity" RELATED [EC:3.1.4.43] +synonym: "inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity" RELATED [EC:3.1.4.43] +xref: EC:3.1.4.43 +xref: MetaCyc:3.1.4.43-RXN +xref: RHEA:14033 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047395 +name: glycerophosphoinositol glycerophosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+)." [EC:3.1.4.44, RHEA:16501] +synonym: "1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44] +synonym: "sn-glycero(3)phosphoinositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44] +synonym: "sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity" RELATED [EC:3.1.4.44] +xref: EC:3.1.4.44 +xref: KEGG_REACTION:R01193 +xref: MetaCyc:3.1.4.44-RXN +xref: Reactome:R-HSA-6813740 "GDE1 hydrolyzes GroPIns" +xref: RHEA:16501 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047396 +name: glycosylphosphatidylinositol diacylglycerol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate." [EC:4.6.1.14, MetaCyc:3.1.4.47-RXN] +synonym: "(glycosyl)phosphatidylinositol-specific phospholipase C activity" RELATED [EC:4.6.1.14] +synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]" RELATED [EC:4.6.1.14] +synonym: "6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity" RELATED [EC:4.6.1.14] +synonym: "glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity" RELATED [EC:4.6.1.14] +synonym: "glycosylphosphatidylinositol-phospholipase C activity" NARROW [EC:4.6.1.14] +synonym: "glycosylphosphatidylinositol-specific phospholipase C activity" RELATED [EC:4.6.1.14] +synonym: "GPI-PLC activity" RELATED [EC:4.6.1.14] +synonym: "GPI-specific phospholipase C activity" RELATED [EC:4.6.1.14] +synonym: "variant-surface-glycoprotein phospholipase C activity" EXACT [] +synonym: "VSG-lipase activity" RELATED [EC:4.6.1.14] +xref: EC:4.6.1.14 +xref: MetaCyc:3.1.4.47-RXN +xref: RHEA:14333 +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0047397 +name: dolichylphosphate-glucose phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose." [EC:3.1.4.48, MetaCyc:3.1.4.48-RXN] +synonym: "Dol-P-Glc phosphodiesterase activity" RELATED [EC:3.1.4.48] +synonym: "dolichol phosphoglucose phosphodiesterase activity" RELATED [EC:3.1.4.48] +synonym: "dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity" RELATED [EC:3.1.4.48] +synonym: "dolichyl-phosphate-glucose phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.48 +xref: MetaCyc:3.1.4.48-RXN +xref: RHEA:13857 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047398 +name: dolichylphosphate-mannose phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose." [EC:3.1.4.49, MetaCyc:3.1.4.49-RXN] +synonym: "dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity" RELATED [EC:3.1.4.49] +synonym: "mannosylphosphodolichol phosphodiesterase activity" RELATED [EC:3.1.4.49] +xref: EC:3.1.4.49 +xref: MetaCyc:3.1.4.49-RXN +xref: RHEA:12989 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0047399 +name: glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate." [EC:3.1.4.51, MetaCyc:3.1.4.51-RXN] +synonym: "6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity" RELATED [EC:3.1.4.51] +synonym: "alpha-glucose-1-phosphate phosphodiesterase activity" RELATED [EC:3.1.4.51] +xref: EC:3.1.4.51 +xref: MetaCyc:3.1.4.51-RXN +xref: RHEA:18045 +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047400 +name: phosphonoacetate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate." [EC:3.11.1.2, RHEA:16749] +synonym: "phosphonoacetate phosphonohydrolase activity" RELATED [EC:3.11.1.2] +xref: EC:3.11.1.2 +xref: KEGG_REACTION:R00318 +xref: MetaCyc:3.11.1.2-RXN +xref: RHEA:16749 +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0047401 +name: trithionate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate." [EC:3.12.1.1, RHEA:21884] +synonym: "trithionate thiosulfohydrolase activity" RELATED [EC:3.12.1.1] +xref: EC:3.12.1.1 +xref: KEGG_REACTION:R01930 +xref: MetaCyc:3.12.1.1-RXN +xref: RHEA:21884 +is_a: GO:0016828 ! hydrolase activity, acting on acid sulfur-sulfur bonds + +[Term] +id: GO:0047402 +name: protein-glucosylgalactosylhydroxylysine glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins." [EC:3.2.1.107, MetaCyc:3.2.1.107-RXN] +synonym: "2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity" RELATED [EC:3.2.1.107] +synonym: "protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity" RELATED [EC:3.2.1.107] +xref: EC:3.2.1.107 +xref: MetaCyc:3.2.1.107-RXN +xref: RHEA:11068 +is_a: GO:0015926 ! glucosidase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0047403 +name: lacto-N-biosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc." [EC:3.2.1.140, MetaCyc:3.2.1.140-RXN] +synonym: "oligosaccharide lacto-N-biosylhydrolase activity" RELATED [EC:3.2.1.140] +xref: EC:3.2.1.140 +xref: RHEA:21568 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047404 +name: glucuronosyl-disulfoglucosamine glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine." [EC:3.2.1.56, MetaCyc:3.2.1.56-RXN] +synonym: "3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" RELATED [EC:3.2.1.56] +synonym: "3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity" RELATED [EC:3.2.1.56] +synonym: "glucuronosyl-disulphoglucosamine glucuronidase activity" EXACT [] +xref: EC:3.2.1.56 +xref: MetaCyc:3.2.1.56-RXN +xref: RHEA:15073 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047405 +name: pyrimidine-5'-nucleotide nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine." [EC:3.2.2.10, MetaCyc:3.2.2.10-RXN] +synonym: "Pyr5N activity" RELATED [EC:3.2.2.10] +synonym: "pyrimidine nucleotide N-ribosidase activity" RELATED [EC:3.2.2.10] +synonym: "pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity" RELATED [EC:3.2.2.10] +xref: EC:3.2.2.10 +xref: MetaCyc:3.2.2.10-RXN +xref: RHEA:13425 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047406 +name: beta-aspartyl-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine." [EC:3.2.2.11, RHEA:12324] +synonym: "1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity" RELATED [EC:3.2.2.11] +synonym: "beta-aspartylacetylglucosaminidase activity" RELATED [EC:3.2.2.11] +xref: EC:3.2.2.11 +xref: KEGG_REACTION:R01266 +xref: MetaCyc:3.2.2.11-RXN +xref: RHEA:12324 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047407 +name: ADP-ribosyl-[dinitrogen reductase] hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]." [EC:3.2.2.24, MetaCyc:3.2.2.24-RXN] +synonym: "ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity" RELATED [EC:3.2.2.24] +synonym: "ADP-ribosyl glycohydrolase activity" RELATED [EC:3.2.2.24] +synonym: "ADP-ribosyl-dinitrogen reductase hydrolase activity" RELATED [EC:3.2.2.24] +synonym: "azoferredoxin glycosidase activity" RELATED [EC:3.2.2.24] +synonym: "azoferredoxin-activating enzymes" RELATED [EC:3.2.2.24] +synonym: "dinitrogenase reductase activating glycohydrolase activity" RELATED [EC:3.2.2.24] +synonym: "dinitrogenase reductase-activating glycohydrolase activity" RELATED [EC:3.2.2.24] +xref: EC:3.2.2.24 +xref: MetaCyc:3.2.2.24-RXN +xref: RHEA:14493 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047408 +name: alkenylglycerophosphocholine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde." [EC:3.3.2.2, MetaCyc:3.3.2.2-RXN] +synonym: "1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity" RELATED [EC:3.3.2.2] +synonym: "lysoplasmalogenase activity" RELATED [EC:3.3.2.2] +xref: EC:3.3.2.2 +xref: MetaCyc:3.3.2.2-RXN +xref: RHEA:22544 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047409 +name: alkenylglycerophosphoethanolamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde." [EC:3.3.2.5, MetaCyc:3.3.2.5-RXN] +synonym: "1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity" RELATED [EC:3.3.2.5] +xref: EC:3.3.2.5 +xref: MetaCyc:3.3.2.5-RXN +xref: RHEA:16905 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047410 +name: N-formylmethionylaminoacyl-tRNA deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate." [MetaCyc:3.5.1.27-RXN] +synonym: "N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity" EXACT [] +xref: MetaCyc:3.5.1.27-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047411 +name: 2-(acetamidomethylene)succinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate." [EC:3.5.1.29, MetaCyc:3.5.1.29-RXN] +synonym: "2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" RELATED [EC:3.5.1.29] +synonym: "alpha-(N-acetylaminomethylene)succinic acid hydrolase activity" RELATED [EC:3.5.1.29] +xref: EC:3.5.1.29 +xref: MetaCyc:3.5.1.29-RXN +xref: RHEA:10432 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047412 +name: N-(long-chain-acyl)ethanolamine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid." [EC:3.5.1.60, MetaCyc:3.5.1.60-RXN] +synonym: "acylethanolamine amidase activity" EXACT [] +synonym: "N-(long-chain-acyl)ethanolamine amidohydrolase activity" EXACT [] +synonym: "N-acylethanolamine amidohydrolase activity" EXACT [] +xref: EC:3.5.1.60 +xref: MetaCyc:3.5.1.60-RXN +xref: RHEA:17505 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047413 +name: N(alpha)-benzyloxycarbonylleucine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2)." [EC:3.5.1.64, RHEA:18901] +synonym: "alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity" RELATED [EC:3.5.1.64] +synonym: "benzyloxycarbonylleucine hydrolase activity" RELATED [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV" RELATED [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity" RELATED [EC:3.5.1.64] +synonym: "nalpha-benzyloxycarbonylleucine hydrolase activity" RELATED [EC:3.5.1.64] +xref: EC:3.5.1.64 +xref: KEGG_REACTION:R02552 +xref: MetaCyc:3.5.1.64-RXN +xref: RHEA:18901 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047414 +name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+)." [EC:3.5.1.66, RHEA:17677] +synonym: "2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)" RELATED [EC:3.5.1.66] +synonym: "alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity" RELATED [EC:3.5.1.66] +synonym: "compound B hydrolase activity" RELATED [EC:3.5.1.66] +xref: EC:3.5.1.66 +xref: KEGG_REACTION:R04397 +xref: MetaCyc:3.5.1.66-RXN +xref: RHEA:17677 +xref: Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating\,_decarboxylating) +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047415 +name: D-benzoylarginine-4-nitroanilide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+)." [EC:3.5.1.72, RHEA:14421] +synonym: "benzoyl-D-arginine arylamidase activity" RELATED [EC:3.5.1.72] +synonym: "D-BAPA-ase activity" RELATED [EC:3.5.1.72] +synonym: "N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity" RELATED [EC:3.5.1.72] +xref: EC:3.5.1.72 +xref: KEGG_REACTION:R04113 +xref: MetaCyc:3.5.1.72-RXN +xref: RHEA:14421 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047416 +name: arylalkyl acylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine." [EC:3.5.1.76, MetaCyc:3.5.1.76-RXN] +synonym: "aralkyl acylamidase activity" RELATED [EC:3.5.1.76] +synonym: "N-acetylarylalkylamine amidohydrolase activity" RELATED [EC:3.5.1.76] +xref: EC:3.5.1.76 +xref: MetaCyc:3.5.1.76-RXN +xref: RHEA:10352 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047417 +name: N-carbamoyl-D-amino acid hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid." [EC:3.5.1.77, MetaCyc:3.5.1.77-RXN] +synonym: "N-carbamoyl-D-amino acid amidohydrolase activity" RELATED [EC:3.5.1.77] +xref: EC:3.5.1.77 +xref: MetaCyc:3.5.1.77-RXN +xref: RHEA:11000 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047418 +name: phthalyl amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine." [EC:3.5.1.79, MetaCyc:3.5.1.79-RXN] +synonym: "o-phthalyl amidase activity" NARROW [EC:3.5.1.79] +synonym: "phthalyl-amide amidohydrolase activity" RELATED [EC:3.5.1.79] +xref: EC:3.5.1.79 +xref: MetaCyc:3.5.1.79-RXN +xref: RHEA:18297 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047419 +name: N-acetylgalactosamine-6-phosphate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate." [EC:3.5.1.25, MetaCyc:3.5.1.80-RXN] +xref: EC:3.5.1.25 +xref: MetaCyc:3.5.1.80-RXN +xref: RHEA:18149 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047420 +name: N-acyl-D-amino-acid deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid." [EC:3.5.1.81, MetaCyc:3.5.1.81-RXN] +synonym: "D-aminoacylase activity" RELATED [EC:3.5.1.81] +synonym: "N-acyl-D-amino acid amidohydrolase activity" RELATED [EC:3.5.1.81] +xref: EC:3.5.1.81 +xref: MetaCyc:3.5.1.81-RXN +xref: RHEA:18309 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047421 +name: N-acyl-D-glutamate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate." [EC:3.5.1.82, RHEA:12833] +synonym: "N-acyl-D-glutamate amidohydrolase activity" RELATED [EC:3.5.1.82] +xref: EC:3.5.1.82 +xref: KEGG_REACTION:R01581 +xref: MetaCyc:3.5.1.82-RXN +xref: RHEA:12833 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047422 +name: N-acyl-D-aspartate deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate." [EC:3.5.1.83, RHEA:18285] +synonym: "N-acyl-D-aspartate amidohydrolase activity" RELATED [EC:3.5.1.83] +xref: EC:3.5.1.83 +xref: KEGG_REACTION:R02182 +xref: MetaCyc:3.5.1.83-RXN +xref: RHEA:18285 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047423 +name: N-methylhydantoinase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate." [EC:3.5.2.14, RHEA:11720] +synonym: "methylhydantoin amidase activity" RELATED [EC:3.5.2.14] +synonym: "N-methylhydantoin amidohydrolase activity" RELATED [EC:3.5.2.14] +synonym: "N-methylhydantoin hydrolase activity" RELATED [EC:3.5.2.14] +synonym: "N-methylhydantoinase (ATP-hydrolysing)" RELATED [EC:3.5.2.14] +synonym: "N-methylhydantoinase activity" RELATED [EC:3.5.2.14] +synonym: "N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)" RELATED [EC:3.5.2.14] +xref: EC:3.5.2.14 +xref: KEGG_REACTION:R03187 +xref: MetaCyc:3.5.2.14-RXN +xref: RHEA:11720 +xref: Wikipedia:N-methylhydantoinase_(ATP-hydrolysing) +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047424 +name: methylenediurea deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea." [EC:3.5.3.21, MetaCyc:3.5.3.21-RXN, RHEA:15929] +synonym: "methylenediurea aminohydrolase activity" RELATED [EC:3.5.3.21] +synonym: "methylenediurease activity" RELATED [EC:3.5.3.21] +xref: EC:3.5.3.21 +xref: MetaCyc:3.5.3.21-RXN +xref: RHEA:15929 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047425 +name: 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+)." [EC:3.5.4.22, RHEA:10560] +synonym: "1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)" RELATED [EC:3.5.4.22] +synonym: "HPC deaminase activity" RELATED [EC:3.5.4.22] +xref: EC:3.5.4.22 +xref: KEGG_REACTION:R02280 +xref: MetaCyc:3.5.4.22-RXN +xref: RHEA:10560 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047426 +name: ricinine nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone." [EC:3.5.5.2, MetaCyc:3.5.5.2-RXN] +synonym: "ricinine aminohydrolase activity" RELATED [EC:3.5.5.2] +xref: EC:3.5.5.2 +xref: MetaCyc:3.5.5.2-RXN +xref: RHEA:22704 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047427 +name: cyanoalanine nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+)." [EC:3.5.5.4, RHEA:11188] +synonym: "3-cyano-L-alanine aminohydrolase activity" RELATED [EC:3.5.5.4] +synonym: "beta-cyanoalanine nitrilase activity" RELATED [EC:3.5.5.4] +xref: EC:3.5.5.4 +xref: KEGG_REACTION:R00486 +xref: MetaCyc:3.5.5.4-RXN +xref: RHEA:11188 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047428 +name: arylacetonitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3." [EC:3.5.5.5, MetaCyc:3.5.5.5-RXN] +synonym: "arylacetonitrile aminohydrolase activity" RELATED [EC:3.5.5.5] +xref: EC:3.5.5.5 +xref: MetaCyc:3.5.5.5-RXN +xref: RHEA:20657 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0047429 +name: nucleoside-triphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide." [MetaCyc:3.6.1.19-RXN] +synonym: "nucleoside-triphosphate diphosphohydrolase activity" RELATED [EC:3.6.1.9] +synonym: "nucleoside-triphosphate pyrophosphatase activity" RELATED [EC:3.6.1.9] +xref: EC:3.6.1.9 +xref: MetaCyc:3.6.1.19-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047430 +name: oligosaccharide-diphosphodolichol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." [EC:3.6.1.44, MetaCyc:3.6.1.44-RXN] +synonym: "oligosaccharide-diphosphodolichol phosphodolichohydrolase activity" RELATED [EC:3.6.1.44] +synonym: "oligosaccharide-diphosphodolichol pyrophosphatase activity" EXACT [] +xref: EC:3.6.1.44 +xref: MetaCyc:3.6.1.44-RXN +xref: RHEA:15205 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047431 +name: 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2)." [EC:4.1.1.51, RHEA:13669] +synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)" RELATED [EC:4.1.1.51] +synonym: "3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity" RELATED [EC:4.1.1.51] +xref: EC:4.1.1.51 +xref: KEGG_REACTION:R03461 +xref: MetaCyc:4.1.1.51-RXN +xref: RHEA:13669 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047432 +name: 2,2-dialkylglycine decarboxylase (pyruvate) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone." [EC:4.1.1.64, RHEA:16073] +synonym: "2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity" RELATED [EC:4.1.1.64] +synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring)" RELATED [EC:4.1.1.64] +synonym: "2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)" RELATED [EC:4.1.1.64] +synonym: "alpha-dialkyl amino acid transaminase activity" RELATED [EC:4.1.1.64] +synonym: "dialkyl amino acid (pyruvate) decarboxylase activity" RELATED [EC:4.1.1.64] +synonym: "dialkylamino-acid decarboxylase (pyruvate)" RELATED [EC:4.1.1.64] +synonym: "L-alanine-alpha-ketobutyrate aminotransferase activity" RELATED [EC:4.1.1.64] +xref: EC:4.1.1.64 +xref: KEGG_REACTION:R03854 +xref: MetaCyc:4.1.1.64-RXN +xref: RHEA:16073 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047433 +name: branched-chain-2-oxoacid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2)." [EC:4.1.1.72, RHEA:21108] +synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)" RELATED [EC:4.1.1.72] +synonym: "(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity" RELATED [EC:4.1.1.72] +synonym: "BCKA" RELATED [EC:4.1.1.72] +synonym: "branched-chain alpha-keto acid decarboxylase activity" RELATED [EC:4.1.1.72] +synonym: "branched-chain keto acid decarboxylase activity" RELATED [EC:4.1.1.72] +synonym: "branched-chain oxo acid decarboxylase activity" RELATED [EC:4.1.1.72] +xref: EC:4.1.1.72 +xref: KEGG_REACTION:R03894 +xref: MetaCyc:4.1.1.72-RXN +xref: RHEA:21108 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047434 +name: indolepyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde." [EC:4.1.1.74, MetaCyc:4.1.1.74-RXN] +synonym: "3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]" RELATED [EC:4.1.1.74] +synonym: "3-(indol-3-yl)pyruvate carboxy-lyase activity" RELATED [EC:4.1.1.74] +synonym: "indol-3-yl-pyruvate carboxy-lyase activity" RELATED [EC:4.1.1.74] +synonym: "indole-3-pyruvate decarboxylase activity" RELATED [EC:4.1.1.74] +xref: EC:4.1.1.74 +xref: MetaCyc:4.1.1.74-RXN +xref: RHEA:18017 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047435 +name: 5-guanidino-2-oxopentanoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2)." [EC:4.1.1.75, RHEA:11340] +synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)" RELATED [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinopentanoate carboxy-lyase activity" RELATED [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinopentanoate decarboxylase activity" RELATED [EC:4.1.1.75] +synonym: "2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity" RELATED [EC:4.1.1.75] +synonym: "alpha-ketoarginine decarboxylase activity" RELATED [EC:4.1.1.75] +xref: EC:4.1.1.75 +xref: KEGG_REACTION:R03178 +xref: MetaCyc:4.1.1.75-RXN +xref: RHEA:11340 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047436 +name: arylmalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2)." [EC:4.1.1.76, RHEA:20513] +synonym: "2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)" RELATED [EC:4.1.1.76] +synonym: "2-aryl-2-methylmalonate carboxy-lyase activity" RELATED [EC:4.1.1.76] +synonym: "AMDASE" RELATED [EC:4.1.1.76] +synonym: "AMDase activity" RELATED [EC:4.1.1.76] +xref: EC:4.1.1.76 +xref: KEGG_REACTION:R05173 +xref: MetaCyc:4.1.1.76-RXN +xref: RHEA:20513 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047437 +name: 4-oxalocrotonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate." [EC:4.1.1.77, MetaCyc:4.1.1.77-RXN] +synonym: "4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)" RELATED [EC:4.1.1.77] +synonym: "4-oxalocrotonate carboxy-lyase activity" RELATED [EC:4.1.1.77] +xref: EC:4.1.1.77 +xref: MetaCyc:4.1.1.77-RXN +xref: RHEA:24260 +xref: UM-BBD_reactionID:r1435 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047438 +name: 2-dehydro-3-deoxy-L-pentonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate." [EC:4.1.2.18, MetaCyc:4.1.2.18-RXN] +synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.18] +synonym: "2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity" RELATED [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-D-xylonate aldolase activity" RELATED [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-L-arabonate aldolase activity" NARROW [EC:4.1.2.18] +synonym: "2-keto-3-deoxy-L-pentonate aldolase activity" RELATED [EC:4.1.2.18] +synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.18] +xref: EC:4.1.2.18 +xref: MetaCyc:4.1.2.18-RXN +xref: RHEA:18545 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047439 +name: 3-deoxy-D-manno-octulosonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate." [EC:4.1.2.23, RHEA:23340] +synonym: "2-keto-3-deoxyoctonate aldolase activity" RELATED [EC:4.1.2.23] +synonym: "2-keto-3-deoxyoctonic aldolase activity" RELATED [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)" RELATED [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonate D-arabinose-lyase activity" RELATED [EC:4.1.2.23] +synonym: "3-deoxy-D-manno-octulosonic aldolase activity" RELATED [EC:4.1.2.23] +synonym: "3-deoxyoctulosonic aldolase activity" RELATED [EC:4.1.2.23] +synonym: "KDOaldolase activity" RELATED [EC:4.1.2.23] +xref: EC:4.1.2.23 +xref: KEGG_REACTION:R01576 +xref: MetaCyc:4.1.2.23-RXN +xref: RHEA:23340 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047440 +name: 2-dehydro-3-deoxy-D-pentonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate." [EC:4.1.2.28, RHEA:20609] +synonym: "2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity" RELATED [EC:4.1.2.28] +synonym: "2-keto-3-deoxy-D-pentonate aldolase activity" RELATED [EC:4.1.2.28] +synonym: "3-deoxy-D-pentulosonic acid aldolase" BROAD [EC:4.1.2.28] +xref: EC:4.1.2.28 +xref: KEGG_REACTION:R01782 +xref: MetaCyc:4.1.2.28-RXN +xref: RHEA:20609 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047441 +name: 5-dehydro-2-deoxyphosphogluconate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate." [EC:4.1.2.29, RHEA:13177] +synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)" RELATED [EC:4.1.2.29] +synonym: "5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity" RELATED [EC:4.1.2.29] +synonym: "phospho-5-dehydro-2-deoxygluconate aldolase activity" RELATED [EC:4.1.2.29] +synonym: "phospho-5-keto-2-deoxygluconate aldolase activity" RELATED [EC:4.1.2.29] +xref: EC:4.1.2.29 +xref: KEGG_REACTION:R05378 +xref: MetaCyc:4.1.2.29-RXN +xref: RHEA:13177 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047442 +name: 17-alpha-hydroxyprogesterone aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione." [EC:4.1.2.30, MetaCyc:4.1.2.30-RXN] +synonym: "17-alpha-hydroxyprogesterone acetaldehyde-lyase activity" RELATED [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)" RELATED [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone acetaldehyde-lyase activity" RELATED [EC:4.1.2.30] +synonym: "17alpha-hydroxyprogesterone aldolase activity" RELATED [EC:4.1.2.30] +synonym: "C-17/C-20 lyase activity" RELATED [EC:4.1.2.30] +xref: EC:4.1.2.30 +xref: MetaCyc:4.1.2.30-RXN +xref: RHEA:14753 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047443 +name: 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." [EC:4.1.3.17, MetaCyc:4.1.3.17-RXN] +synonym: "4-hydroxy-4-methyl-2-ketoglutarate aldolase activity" RELATED [EC:4.1.3.17] +synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)" RELATED [EC:4.1.3.17] +synonym: "4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity" RELATED [EC:4.1.3.17] +synonym: "gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity" RELATED [EC:4.1.3.17] +synonym: "pyruvate aldolase activity" RELATED [EC:4.1.3.17] +xref: EC:4.1.3.17 +xref: MetaCyc:4.1.3.17-RXN +xref: RHEA:22748 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047444 +name: N-acylneuraminate-9-phosphate synthase activity +namespace: molecular_function +alt_id: GO:0019007 +def: "Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate." [EC:2.5.1.57, MetaCyc:4.1.3.20-RXN] +synonym: "N-acetylneuraminate 9-phosphate lyase activity" RELATED [EC:2.5.1.57] +synonym: "N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity" RELATED [EC:2.5.1.57] +synonym: "N-acetylneuraminate 9-phosphate synthetase activity" RELATED [EC:2.5.1.57] +synonym: "N-acetylneuraminic acid phosphate synthase activity" EXACT [GOC:mah] +synonym: "N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.57] +synonym: "phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity" RELATED [EC:2.5.1.57] +synonym: "sialic acid 9-phosphate synthetase activity" RELATED [EC:2.5.1.57] +xref: EC:2.5.1.57 +xref: MetaCyc:4.1.3.20-RXN +xref: Reactome:R-HSA-4084976 "NANS converts ManNAc-6-P to Neu5Ac-9-P" +xref: RHEA:13421 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047445 +name: 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate." [EC:4.1.3.26, RHEA:23084] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)" RELATED [EC:4.1.3.26] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity" RELATED [EC:4.1.3.26] +synonym: "3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity" RELATED [EC:4.1.3.26] +synonym: "3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity" RELATED [EC:4.1.3.26] +synonym: "beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity" RELATED [EC:4.1.3.26] +synonym: "hydroxyisohexenylglutaryl-CoA:acetatelyase activity" RELATED [EC:4.1.3.26] +xref: EC:4.1.3.26 +xref: KEGG_REACTION:R08090 +xref: MetaCyc:4.1.3.26-RXN +xref: RHEA:23084 +xref: UM-BBD_reactionID:r1168 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047446 +name: (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone." [EC:4.1.3.35, RHEA:23868] +synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.35] +synonym: "(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity" RELATED [EC:4.1.3.35] +xref: EC:4.1.3.35 +xref: KEGG_REACTION:R02232 +xref: MetaCyc:4.1.3.35-RXN +xref: RHEA:23868 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047447 +name: erythro-3-hydroxyaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid." [EC:4.3.1.20, MetaCyc:4.3.1.20-RXN] +synonym: "3-hydroxyaspartate dehydratase activity" BROAD [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)" RELATED [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity" RELATED [EC:4.3.1.20] +synonym: "erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)" RELATED [EC:4.3.1.20] +synonym: "erythro-3-hydroxyaspartate dehydratase activity" EXACT [] +synonym: "erythro-beta-hydroxyaspartate dehydratase activity" RELATED [EC:4.3.1.20] +xref: EC:4.3.1.20 +xref: MetaCyc:4.3.1.20-RXN +xref: RHEA:19757 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047448 +name: 5-dehydro-4-deoxyglucarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O." [EC:4.2.1.41, RHEA:24608] +synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.41] +synonym: "5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)" RELATED [EC:4.2.1.41] +synonym: "5-keto-4-deoxy-glucarate dehydratase activity" RELATED [EC:4.2.1.41] +synonym: "D-4-deoxy-5-ketoglucarate hydro-lyase activity" RELATED [EC:4.2.1.41] +synonym: "deoxyketoglucarate dehydratase activity" RELATED [EC:4.2.1.41] +xref: EC:4.2.1.41 +xref: KEGG_REACTION:R02279 +xref: MetaCyc:4.2.1.41-RXN +xref: RHEA:24608 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047449 +name: 2-dehydro-3-deoxy-L-arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O." [EC:4.2.1.43, RHEA:17201] +synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)" RELATED [EC:4.2.1.43] +synonym: "2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.43] +synonym: "2-keto-3-deoxy-L-arabinonate dehydratase activity" RELATED [EC:4.2.1.43] +xref: EC:4.2.1.43 +xref: KEGG_REACTION:R02278 +xref: MetaCyc:4.2.1.43-RXN +xref: RHEA:17201 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047450 +name: crotonoyl-[acyl-carrier-protein] hydratase activity +namespace: molecular_function +alt_id: GO:0080063 +def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]." [EC:4.2.1.58, MetaCyc:4.2.1.58-RXN] +synonym: "(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity" RELATED [EC:4.2.1.58] +synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)" RELATED [EC:4.2.1.58] +synonym: "(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity" RELATED [EC:4.2.1.58] +synonym: "3-hydroxybutyryl acyl carrier protein dehydratase activity" RELATED [EC:4.2.1.58] +synonym: "beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity" RELATED [EC:4.2.1.58] +synonym: "beta-hydroxybutyryl acyl carrier protein dehydrase activity" RELATED [EC:4.2.1.58] +synonym: "crotonoyl-[acyl-carrier protein] hydratase activity" EXACT [] +synonym: "crotonoyl-ACP hydratase activity" EXACT [] +synonym: "crotonoyl-acyl-carrier-protein hydratase activity" RELATED [EC:4.2.1.58] +synonym: "crotonyl acyl carrier protein hydratase activity" RELATED [EC:4.2.1.58] +synonym: "enoyl acyl carrier protein hydrase activity" RELATED [EC:4.2.1.58] +xref: EC:4.2.1.58 +xref: KEGG_REACTION:R04428 +xref: MetaCyc:4.2.1.58-RXN +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0047451 +name: 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]." [PMID:8910376, RHEA:41844] +synonym: "(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity" RELATED [EC:4.2.1.59] +synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming)" RELATED [EC:4.2.1.59] +synonym: "(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity" RELATED [EC:4.2.1.59] +synonym: "3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] +synonym: "3-hydroxyoctanoyl-ACP dehydratase activity" EXACT [] +synonym: "3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl thioester dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl-ACP-dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity" RELATED [EC:4.2.1.59] +synonym: "D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity" RELATED [EC:4.2.1.59] +xref: EC:4.2.1.59 +xref: KEGG_REACTION:R04537 +xref: MetaCyc:4.2.1.59-RXN +xref: RHEA:41844 +is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity + +[Term] +id: GO:0047452 +name: protoaphin-aglucone dehydratase (cyclizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin." [EC:4.2.1.73, RHEA:23876] +synonym: "protoaphin dehydratase (cyclizing)" RELATED [EC:4.2.1.73] +synonym: "protoaphin dehydratase activity" RELATED [EC:4.2.1.73] +synonym: "protoaphin-aglucone hydro-lyase (cyclizing)" RELATED [EC:4.2.1.73] +synonym: "protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)" RELATED [EC:4.2.1.73] +xref: EC:4.2.1.73 +xref: KEGG_REACTION:R03742 +xref: MetaCyc:4.2.1.73-RXN +xref: RHEA:23876 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047453 +name: ATP-dependent NAD(P)H-hydrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate." [PMID:3061454, RHEA:19017] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)" RELATED [EC:4.2.1.93] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.93] +synonym: "ATP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] +synonym: "ATP-dependent H4NAD(P)OH dehydratase activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93] +xref: EC:4.2.1.93 +xref: KEGG_REACTION:R00129 +xref: MetaCyc:4.2.1.93-RXN +xref: Reactome:R-HSA-6806967 "CARKD dehydrates S-NAD(P)HX to NADPH" +xref: RHEA:19017 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047454 +name: phaseollidin hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin." [EC:4.2.1.97, RHEA:19769] +synonym: "phaseollidin-hydrate hydro-lyase (phaseollidin-forming)" RELATED [EC:4.2.1.97] +synonym: "phaseollidin-hydrate hydro-lyase activity" RELATED [EC:4.2.1.97] +xref: EC:4.2.1.97 +xref: KEGG_REACTION:R04728 +xref: MetaCyc:4.2.1.97-RXN +xref: RHEA:19769 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047455 +name: 16-alpha-hydroxyprogesterone dehydratase activity +namespace: molecular_function +alt_id: GO:0047523 +def: "Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone." [EC:4.2.1.98, MetaCyc:4.2.1.98-RXN] +synonym: "16-alpha-dehydroxylase activity" RELATED [EC:4.2.1.98] +synonym: "16-alpha-hydroxyprogesterone dehydroxylase activity" RELATED [EC:4.2.1.98] +synonym: "16-dehydroprogesterone hydratase activity" RELATED [] +synonym: "16alpha-dehydroxylase activity" RELATED [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone dehydratase activity" RELATED [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone dehydroxylase activity" RELATED [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)" RELATED [EC:4.2.1.98] +synonym: "16alpha-hydroxyprogesterone hydro-lyase activity" RELATED [EC:4.2.1.98] +synonym: "hydroxyprogesterone dehydroxylase activity" EXACT [] +xref: EC:4.2.1.98 +xref: MetaCyc:4.2.1.98-RXN +xref: RHEA:12584 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047456 +name: 2-methylisocitrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.99, RHEA:17941] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.99] +synonym: "(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.99] +xref: EC:4.2.1.99 +xref: KEGG_REACTION:R04425 +xref: MetaCyc:4.2.1.99-RXN +xref: RHEA:17941 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047457 +name: exo-(1,4)-alpha-D-glucan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose." [EC:4.2.2.13, MetaCyc:4.2.2.13-RXN] +synonym: "(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)" RELATED [EC:4.2.2.13] +synonym: "alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity" RELATED [EC:4.2.2.13] +synonym: "alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity" RELATED [EC:4.2.2.13] +synonym: "alpha-1,4-glucan exo-lyase activity" RELATED [EC:4.2.2.13] +synonym: "alpha-1,4-glucan lyase activity" BROAD [EC:4.2.2.13] +synonym: "exo-(1->4)-alpha-D-glucan lyase activity" RELATED [EC:4.2.2.13] +synonym: "exo-alpha-1,4-glucan lyase activity" RELATED [EC:4.2.2.13] +xref: EC:4.2.2.13 +xref: MetaCyc:4.2.2.13-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047458 +name: beta-pyrazolylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+)." [EC:2.5.1.51, RHEA:13117] +synonym: "3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.51] +synonym: "beta-(1-pyrazolyl)alanine synthase activity" RELATED [EC:2.5.1.51] +synonym: "beta-pyrazolealanine synthase activity" RELATED [EC:2.5.1.51] +synonym: "beta-pyrazolylalanine synthase (acetylserine) activity" EXACT [] +synonym: "BPA-synthase activity" RELATED [EC:2.5.1.51] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity" RELATED [EC:2.5.1.51] +synonym: "O3-acetyl-L-serine acetate-lyase (adding pyrazole)" RELATED [EC:2.5.1.51] +synonym: "O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.51] +synonym: "pyrazolealanine synthase activity" RELATED [EC:2.5.1.51] +synonym: "pyrazolylalaninase activity" RELATED [EC:2.5.1.51] +xref: EC:2.5.1.51 +xref: KEGG_REACTION:R03134 +xref: MetaCyc:2.5.1.51-RXN +xref: RHEA:13117 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047459 +name: 3-aminobutyryl-CoA ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+)." [EC:4.3.1.14, RHEA:10056] +synonym: "L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)" RELATED [EC:4.3.1.14] +synonym: "L-3-aminobutyryl-CoA ammonia-lyase activity" RELATED [EC:4.3.1.14] +synonym: "L-3-aminobutyryl-CoA deaminase activity" RELATED [EC:4.3.1.14] +xref: EC:4.3.1.14 +xref: KEGG_REACTION:R03030 +xref: MetaCyc:4.3.1.14-RXN +xref: RHEA:10056 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047460 +name: L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+)." [EC:4.5.1.4, RHEA:11620] +synonym: "L-2-amino-4-chloro-4-pentenoate dehalogenase activity" RELATED [EC:4.5.1.4] +synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming)" RELATED [EC:4.5.1.4] +synonym: "L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)" RELATED [EC:4.5.1.4] +xref: EC:4.5.1.4 +xref: KEGG_REACTION:R02605 +xref: MetaCyc:4.5.1.4-RXN +xref: RHEA:11620 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0047461 +name: (+)-delta-cadinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene." [EC:4.2.3.13, MetaCyc:4.6.1.11-RXN] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)" RELATED [EC:4.2.3.13] +synonym: "D-cadinene synthase activity" RELATED [EC:4.2.3.13] +xref: EC:4.2.3.13 +xref: MetaCyc:4.6.1.11-RXN +xref: RHEA:19525 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0047462 +name: phenylalanine racemase (ATP-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+)." [EC:5.1.1.11, RHEA:20201] +synonym: "gramicidin S synthetase I" RELATED [EC:5.1.1.11] +synonym: "phenylalanine racemase (adenosine triphosphate-hydrolysing)" RELATED [EC:5.1.1.11] +synonym: "phenylalanine racemase (ATP-hydrolysing)" BROAD [EC:5.1.1.11] +synonym: "phenylalanine racemase activity" RELATED [EC:5.1.1.11] +xref: EC:5.1.1.11 +xref: KEGG_REACTION:R00686 +xref: MetaCyc:5.1.1.11-RXN +xref: RHEA:20201 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0047463 +name: 2-aminohexano-6-lactam racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam." [EC:5.1.1.15, RHEA:14813] +synonym: "2-amino-hexano-6-lactam racemase activity" RELATED [EC:5.1.1.15] +synonym: "alpha-amino-epsilon-caprolactam racemase activity" RELATED [EC:5.1.1.15] +xref: EC:5.1.1.15 +xref: KEGG_REACTION:R04736 +xref: MetaCyc:5.1.1.15-RXN +xref: RHEA:14813 +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047464 +name: heparosan-N-sulfate-glucuronate 5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] +synonym: "C-5 uronosyl epimerase activity" RELATED [EC:5.1.3.17] +synonym: "D-glucuronyl C-5 epimerase activity" RELATED [EC:5.1.3.17] +synonym: "heparosan epimerase activity" RELATED [EC:5.1.3.17] +synonym: "heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity" RELATED [EC:5.1.3.17] +synonym: "heparosan-N-sulphate-glucuronate 5-epimerase activity" EXACT [] +synonym: "poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity" RELATED [EC:5.1.3.17] +synonym: "polyglucuronate epimerase activity" RELATED [EC:5.1.3.17] +xref: EC:5.1.3.17 +xref: MetaCyc:5.1.3.17-RXN +xref: RHEA:20197 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047465 +name: N-acylglucosamine-6-phosphate 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate." [EC:5.1.3.9, MetaCyc:5.1.3.9-RXN] +synonym: "acylglucosamine phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +synonym: "acylglucosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +synonym: "acylmannosamine phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +synonym: "N-acetylglucosmamine 6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +synonym: "N-acetylmannosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +synonym: "N-acyl-D-glucosamine-6-phosphate 2-epimerase activity" RELATED [EC:5.1.3.9] +xref: EC:5.1.3.9 +xref: MetaCyc:5.1.3.9-RXN +xref: RHEA:23932 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047466 +name: 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity +namespace: molecular_function +alt_id: GO:0018840 +def: "Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide." [EC:5.2.1.10, RHEA:10924] +synonym: "2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity" RELATED [EC:5.2.1.10] +synonym: "2-chlorocarboxymethylenebutenolide isomerase activity" RELATED [EC:5.2.1.-] +synonym: "chlorodienelactone isomerase activity" RELATED [EC:5.2.1.-] +xref: EC:5.2.1.10 +xref: KEGG_REACTION:R04576 +xref: MetaCyc:5.2.1.10-RXN +xref: RHEA:10924 +xref: UM-BBD_reactionID:r0278 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047467 +name: 4-hydroxyphenylacetaldehyde-oxime isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime." [EC:5.2.1.11, MetaCyc:5.2.1.11-RXN] +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047468 +name: phosphoglucomutase (glucose-cofactor) activity +namespace: molecular_function +def: "Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor." [EC:5.4.2.5, MetaCyc:5.4.2.5-RXN] +synonym: "alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)" RELATED [EC:5.4.2.5] +synonym: "glucose-1-phosphate phosphotransferase activity" RELATED [EC:5.4.2.5] +xref: EC:5.4.2.5 +xref: MetaCyc:5.4.2.5-RXN +is_a: GO:0004614 ! phosphoglucomutase activity + +[Term] +id: GO:0047469 +name: 4-carboxymethyl-4-methylbutenolide mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide." [EC:5.4.99.14, RHEA:19237] +synonym: "4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity" RELATED [EC:5.4.99.14] +synonym: "4-methyl-2-enelactone isomerase activity" RELATED [EC:5.4.99.14] +synonym: "4-methyl-2-enelactone methyl-isomerase activity" RELATED [EC:5.4.99.14] +synonym: "4-methyl-3-enelactone methyl isomerase activity" RELATED [EC:5.4.99.14] +synonym: "4-methylmuconolactone methylisomerase activity" RELATED [EC:5.4.99.14] +xref: EC:5.4.99.14 +xref: KEGG_REACTION:R04510 +xref: MetaCyc:5.4.99.14-RXN +xref: RHEA:19237 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047470 +name: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside." [EC:5.4.99.15, MetaCyc:5.4.99.15-RXN] +synonym: "(1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase" BROAD [EC:5.4.99.15] +synonym: "malto-oligosyltrehalose synthase activity" RELATED [EC:5.4.99.15] +synonym: "maltodextrin alpha-D-glucosyltransferase activity" RELATED [EC:5.4.99.15] +xref: EC:5.4.99.15 +xref: MetaCyc:5.4.99.15-RXN +xref: RHEA:13621 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047471 +name: maltose alpha-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltose = trehalose." [EC:5.4.99.16, MetaCyc:5.4.99.16-RXN] +synonym: "maltose alpha-D-glucosylmutase activity" RELATED [EC:5.4.99.16] +synonym: "maltose glucosylmutase activity" RELATED [EC:5.4.99.16] +synonym: "trehalose synthase activity" RELATED [EC:5.4.99.16] +xref: EC:5.4.99.16 +xref: MetaCyc:5.4.99.16-RXN +xref: RHEA:15145 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047472 +name: 3-carboxy-cis,cis-muconate cycloisomerase activity +namespace: molecular_function +alt_id: GO:0018842 +def: "Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+)." [PMID:15301541, PMID:17054713, RHEA:23656] +synonym: "3-carboxymuconate cycloisomerase type II activity" RELATED [] +synonym: "3-carboxymuconate lactonizing enzyme activity" RELATED [EC:5.5.1.2] +synonym: "3-carboxymuconolactone hydrolase activity" RELATED [] +synonym: "beta-carboxymuconate lactonizing enzyme activity" RELATED [EC:5.5.1.2] +synonym: "CMLE activity" RELATED [EC:5.5.1.2] +xref: EC:5.5.1.2 +xref: KEGG_REACTION:R03307 +xref: MetaCyc:5.5.1.2-RXN +xref: RHEA:23656 +xref: UM-BBD_reactionID:r0582 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047473 +name: D-alanine [D-alanyl carrier protein] ligase activity +namespace: molecular_function +def: "Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate." [GOC:pg] +synonym: "D-alanine-activating enzyme activity" RELATED [] +synonym: "D-alanine-D-alanyl carrier protein ligase activity" RELATED [EC:6.2.1.-] +synonym: "D-alanine-poly(phosphoribitol) ligase activity" BROAD [] +synonym: "D-alanine:poly(phosphoribitol) ligase (AMP-forming)" BROAD [] +xref: EC:6.2.1.- +xref: MetaCyc:6.2.1.M5-RXN +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047474 +name: long-chain fatty acid luciferin component ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [EC:6.2.1.19, MetaCyc:6.2.1.19-RXN] +synonym: "acyl-protein synthetase activity" RELATED [EC:6.2.1.19] +synonym: "long-chain-fatty-acid luciferin component ligase activity" EXACT [GOC:mah] +synonym: "long-chain-fatty-acid-luciferin-component ligase activity" EXACT [] +synonym: "long-chain-fatty-acid:protein ligase (AMP-forming)" RELATED [EC:6.2.1.19] +xref: EC:6.2.1.19 +xref: MetaCyc:6.2.1.19-RXN +xref: RHEA:20101 +is_a: GO:0015645 ! fatty acid ligase activity + +[Term] +id: GO:0047475 +name: phenylacetate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA." [EC:6.2.1.30, RHEA:20956] +synonym: "PA-CoA ligase activity" RELATED [EC:6.2.1.30] +synonym: "phenacyl coenzyme A synthetase activity" RELATED [EC:6.2.1.30] +synonym: "phenylacetate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.30] +synonym: "phenylacetyl-CoA ligase (AMP-forming)" RELATED [EC:6.2.1.30] +synonym: "phenylacetyl-CoA ligase activity" RELATED [EC:6.2.1.30] +xref: EC:6.2.1.30 +xref: KEGG_REACTION:R02539 +xref: MetaCyc:PHENYLACETATE--COA-LIGASE-RXN +xref: RHEA:20956 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047476 +name: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP." [EC:6.2.1.28, MetaCyc:6.2.1.28-RXN] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity" RELATED [EC:6.2.1.28] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.28] +synonym: "3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.28] +synonym: "DHCA-CoA ligase activity" RELATED [EC:6.2.1.28] +xref: EC:6.2.1.28 +xref: MetaCyc:6.2.1.28-RXN +xref: RHEA:21776 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047478 +name: aspartate-ammonia ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate." [EC:6.3.1.4, RHEA:14197] +synonym: "asparagine synthetase (adenosine diphosphate-forming)" RELATED [EC:6.3.1.4] +synonym: "asparagine synthetase (ADP-forming) activity" RELATED [EC:6.3.1.4] +synonym: "L-aspartate:ammonia ligase (ADP-forming)" RELATED [EC:6.3.1.4] +xref: EC:6.3.1.4 +xref: KEGG_REACTION:R00482 +xref: MetaCyc:6.3.1.4-RXN +xref: RHEA:14197 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047479 +name: trypanothione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate." [EC:6.3.1.9, MetaCyc:6.3.1.9-RXN] +synonym: "glutathionylspermidine:glutathione ligase (ADP-forming)" RELATED [EC:6.3.1.9] +synonym: "TSR synthetase activity" RELATED [EC:6.3.1.9] +xref: EC:6.3.1.9 +xref: MetaCyc:6.3.1.9-RXN +xref: RHEA:21532 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047480 +name: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP." [EC:6.3.2.10, MetaCyc:6.3.2.10-RXN] +comment: Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). +synonym: "MurF synthetase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-MurNAc-pentapeptide synthetase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" EXACT [] +synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity" RELATED [EC:6.3.2.10] +synonym: "UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity" EXACT [] +synonym: "UDPacetylmuramoylpentapeptide synthetase activity" RELATED [EC:6.3.2.10] +synonym: "uridine diphosphoacetylmuramoylpentapeptide synthetase activity" RELATED [EC:6.3.2.10] +xref: EC:6.3.2.10 +xref: MetaCyc:6.3.2.10-RXN +xref: RHEA:16085 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047481 +name: D-alanine-alanyl-poly(glycerolphosphate) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP." [EC:6.3.2.16, MetaCyc:6.3.2.16-RXN] +synonym: "D-alanine-membrane acceptor-ligase activity" RELATED [EC:6.3.2.16] +synonym: "D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)" RELATED [EC:6.3.2.16] +synonym: "D-alanine:membrane-acceptor ligase activity" RELATED [EC:6.3.2.16] +synonym: "D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity" RELATED [EC:6.3.2.16] +synonym: "D-alanyl-poly(phosphoglycerol) synthetase activity" RELATED [EC:6.3.2.16] +synonym: "D-alanylalanylpoly(phosphoglycerol) synthetase activity" RELATED [EC:6.3.2.16] +xref: EC:6.3.2.16 +xref: MetaCyc:6.3.2.16-RXN +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047482 +name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine." [EC:6.3.2.7, RHEA:17969] +synonym: "L-lysine-adding enzyme activity" RELATED [EC:6.3.2.7] +synonym: "MurE synthetase activity" RELATED [EC:6.3.2.7] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)" RELATED [EC:6.3.2.7] +synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity" RELATED [EC:6.3.2.7] +synonym: "UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity" RELATED [EC:6.3.2.7] +synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity" RELATED [EC:6.3.2.7] +xref: EC:6.3.2.7 +xref: KEGG_REACTION:R02786 +xref: MetaCyc:6.3.2.7-RXN +xref: RHEA:17969 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047483 +name: imidazoleacetate-phosphoribosyldiphosphate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate." [EC:6.3.4.8, RHEA:16485] +synonym: "5-phosphoribosylimidazoleacetate synthetase activity" RELATED [EC:6.3.4.8] +synonym: "imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)" RELATED [EC:6.3.4.8] +xref: EC:6.3.4.8 +xref: KEGG_REACTION:R04068 +xref: MetaCyc:6.3.4.8-RXN +xref: RHEA:16485 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047484 +name: regulation of response to osmotic stress +namespace: biological_process +def: "Any process that modulates the rate or extent of the response to osmotic stress." [GOC:ai] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0006970 ! response to osmotic stress + +[Term] +id: GO:0047485 +name: protein N-terminus binding +namespace: molecular_function +def: "Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] +synonym: "amino-terminal binding" RELATED [GOC:jsg] +synonym: "amino-terminus binding" RELATED [GOC:jsg] +synonym: "N-terminal binding" EXACT [] +synonym: "N-terminal end binding" EXACT [GOC:jsg] +synonym: "NH2-terminal binding" NARROW [GOC:jsg] +synonym: "NH2-terminus binding" NARROW [GOC:jsg] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0047486 +name: chondroitin ABC lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [GOC:hjd] +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047487 +name: oligogalacturonide lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate." [EC:4.2.2.6, MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN] +synonym: "OGTE" RELATED [EC:4.2.2.6] +synonym: "oligogalacturonate lyase activity" RELATED [EC:4.2.2.6] +synonym: "unsaturated oligogalacturonate transeliminase activity" RELATED [EC:4.2.2.6] +xref: EC:4.2.2.6 +xref: MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN +xref: RHEA:20269 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047488 +name: heparin lyase activity +namespace: molecular_function +def: "Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.7, MetaCyc:4.2.2.7-RXN] +synonym: "heparan sulfate lyase activity" RELATED [] +synonym: "heparin eliminase activity" RELATED [EC:4.2.2.7] +synonym: "heparinase activity" RELATED [EC:4.2.2.7] +xref: EC:4.2.2.7 +xref: MetaCyc:4.2.2.7-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047489 +name: pectate disaccharide-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin." [EC:4.2.2.9] +synonym: "(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity" RELATED [EC:4.2.2.9] +synonym: "exo-PATE" RELATED [EC:4.2.2.9] +synonym: "Exo-PATE activity" RELATED [EC:4.2.2.9] +synonym: "exo-PGL" RELATED [EC:4.2.2.9] +synonym: "Exo-PGL activity" RELATED [EC:4.2.2.9] +synonym: "exopectate lyase activity" RELATED [EC:4.2.2.9] +synonym: "exopectic acid transeliminase activity" RELATED [EC:4.2.2.9] +synonym: "exopolygalacturonate lyase activity" RELATED [EC:4.2.2.9] +synonym: "exopolygalacturonic acid-trans-eliminase activity" RELATED [EC:4.2.2.9] +synonym: "PATE activity" RELATED [EC:4.2.2.9] +synonym: "pectate exo-lyase activity" RELATED [EC:4.2.2.9] +xref: EC:4.2.2.9 +xref: MetaCyc:4.2.2.9-RXN +xref: RHEA:57104 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047490 +name: pectin lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.10] +synonym: "(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity" RELATED [EC:4.2.2.10] +synonym: "endo-pectin lyase activity" RELATED [EC:4.2.2.10] +synonym: "pectin methyltranseliminase activity" RELATED [EC:4.2.2.10] +synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.10] +synonym: "pectolyase activity" RELATED [EC:4.2.2.10] +synonym: "PL activity" RELATED [EC:4.2.2.10] +synonym: "PMGL activity" RELATED [EC:4.2.2.10] +synonym: "PNL activity" RELATED [EC:4.2.2.10] +synonym: "polymethylgalacturonic transeliminase activity" RELATED [EC:4.2.2.10] +xref: EC:4.2.2.10 +xref: MetaCyc:4.2.2.10-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047491 +name: poly(alpha-L-guluronate) lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends." [EC:4.2.2.11] +synonym: "alginase II activity" RELATED [EC:4.2.2.11] +synonym: "guluronate lyase activity" RELATED [EC:4.2.2.11] +synonym: "L-guluronan lyase activity" RELATED [EC:4.2.2.11] +synonym: "L-guluronate lyase activity" RELATED [EC:4.2.2.11] +synonym: "poly(alpha-L-1,4-guluronide) exo-lyase activity" RELATED [EC:4.2.2.11] +synonym: "poly-alpha-L-guluronate lyase activity" RELATED [EC:4.2.2.11] +synonym: "polyguluronate-specific alginate lyase activity" RELATED [EC:4.2.2.11] +xref: EC:4.2.2.11 +xref: MetaCyc:4.2.2.11-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047492 +name: xanthan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain." [EC:4.2.2.12] +xref: EC:4.2.2.12 +xref: MetaCyc:4.2.2.12-RXN +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0047493 +name: ceramide cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin." [EC:2.7.8.3, RHEA:16273] +synonym: "CDP-choline:N-acylsphingosine cholinephosphotransferase activity" RELATED [EC:2.7.8.3] +synonym: "phosphorylcholine-ceramide transferase activity" RELATED [EC:2.7.8.3] +xref: EC:2.7.8.3 +xref: KEGG_REACTION:R01891 +xref: MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN +xref: RHEA:16273 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047494 +name: serine-phosphoethanolamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+)." [EC:2.7.8.4, RHEA:22656] +synonym: "CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity" RELATED [EC:2.7.8.4] +synonym: "serine ethanolamine phosphate synthetase activity" RELATED [EC:2.7.8.4] +synonym: "serine ethanolamine phosphodiester synthase activity" RELATED [EC:2.7.8.4] +synonym: "serine ethanolaminephosphotransferase activity" RELATED [EC:2.7.8.4] +synonym: "serine-phosphinico-ethanolamine synthase activity" RELATED [EC:2.7.8.4] +synonym: "serinephosphoethanolamine synthase activity" RELATED [EC:2.7.8.4] +xref: EC:2.7.8.4 +xref: KEGG_REACTION:R02563 +xref: MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN +xref: RHEA:22656 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047495 +name: membrane-oligosaccharide glycerophosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another." [EC:2.7.8.21] +synonym: "membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" RELATED [EC:2.7.8.21] +synonym: "periplasmic phosphoglycerotransferase activity" NARROW [EC:2.7.8.21] +synonym: "phosphoglycerol cyclase activity" RELATED [EC:2.7.8.21] +xref: EC:2.7.8.21 +xref: MetaCyc:2.7.8.21-RXN +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0047496 +name: vesicle transport along microtubule +namespace: biological_process +def: "The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:ecd, GOC:rl] +synonym: "microtubule-based vesicle localization" EXACT [GOC:rl] +is_a: GO:0072384 ! organelle transport along microtubule +is_a: GO:0099518 ! vesicle cytoskeletal trafficking + +[Term] +id: GO:0047497 +name: mitochondrion transport along microtubule +namespace: biological_process +def: "The directed movement of a mitochondrion along a microtubule, mediated by motor proteins." [GOC:ecd] +synonym: "mitochondrial migration along microtubule" EXACT [] +synonym: "mitochondrial transport along microtubule" EXACT [] +is_a: GO:0034643 ! establishment of mitochondrion localization, microtubule-mediated +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0047498 +name: calcium-dependent phospholipase A2 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+." [EC:3.1.1.4] +synonym: "calcium-dependent cytosolic phospholipase A2 activity" NARROW [] +synonym: "calcium-dependent secreted phospholipase A2 activity" NARROW [] +xref: Reactome:R-HSA-111883 "Hydrolysis of phosphatidylcholine" +is_a: GO:0004623 ! phospholipase A2 activity + +[Term] +id: GO:0047499 +name: calcium-independent phospholipase A2 activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4] +subset: goslim_chembl +synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] +xref: Reactome:R-HSA-8952251 "PLA2G15 hydrolyses LPC to GPCho and LCFA(-)" +is_a: GO:0004623 ! phospholipase A2 activity + +[Term] +id: GO:0047500 +name: (+)-borneol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH." [EC:1.1.1.198, RHEA:17329] +synonym: "(+)-borneol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.198] +synonym: "bicyclic monoterpenol dehydrogenase activity" RELATED [EC:1.1.1.198] +xref: EC:1.1.1.198 +xref: KEGG_REACTION:R02944 +xref: MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN +xref: RHEA:17329 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047501 +name: (+)-neomenthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.208, RHEA:23812] +synonym: "(+)-neomenthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.208] +synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.208] +xref: EC:1.1.1.208 +xref: KEGG_REACTION:R02548 +xref: MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN +xref: RHEA:23812 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047502 +name: (+)-sabinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH." [EC:1.1.1.228, RHEA:18329] +synonym: "(+)-cis-sabinol dehydrogenase activity" RELATED [EC:1.1.1.228] +synonym: "(+)-cis-sabinol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.228] +xref: EC:1.1.1.228 +xref: KEGG_REACTION:R03745 +xref: MetaCyc:+-SABINOL-DEHYDROGENASE-RXN +xref: RHEA:18329 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047503 +name: (-)-borneol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH." [EC:1.1.1.227, RHEA:22128] +synonym: "(-)-borneol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.227] +xref: EC:1.1.1.227 +xref: KEGG_REACTION:R02945 +xref: MetaCyc:--BORNEOL-DEHYDROGENASE-RXN +xref: RHEA:22128 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047504 +name: (-)-menthol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH." [EC:1.1.1.207, RHEA:13917] +synonym: "(-)-menthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.207] +synonym: "monoterpenoid dehydrogenase activity" BROAD [EC:1.1.1.207] +xref: EC:1.1.1.207 +xref: KEGG_REACTION:R02177 +xref: MetaCyc:--MENTHOL-DEHYDROGENASE-RXN +xref: RHEA:13917 +xref: UM-BBD_reactionID:r1182 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047505 +name: (-)-menthol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+)." [EC:1.14.13.46, RHEA:11648] +synonym: "(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)" RELATED [EC:1.14.13.46] +synonym: "l-menthol monooxygenase activity" RELATED [EC:1.14.13.46] +xref: EC:1.14.13.46 +xref: KEGG_REACTION:R02178 +xref: MetaCyc:--MENTHOL-MONOOXYGENASE-RXN +xref: RHEA:11648 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047506 +name: (deoxy)adenylate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dAMP = ADP + dADP." [EC:2.7.4.11, MetaCyc:DEOXYADENYLATE-KINASE-RXN] +synonym: "ATP:(d)AMP phosphotransferase activity" RELATED [EC:2.7.4.11] +xref: EC:2.7.4.11 +xref: MetaCyc:DEOXYADENYLATE-KINASE-RXN +xref: RHEA:23100 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047507 +name: (deoxy)nucleoside-phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate." [EC:2.7.4.13, MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN] +synonym: "ATP:deoxynucleoside-phosphate phosphotransferase activity" RELATED [EC:2.7.4.13] +synonym: "deoxynucleoside monophosphate kinase activity" RELATED [EC:2.7.4.13] +synonym: "deoxynucleoside-5'-monophosphate kinase activity" RELATED [EC:2.7.4.13] +synonym: "deoxyribonucleoside monophosphokinase activity" RELATED [EC:2.7.4.13] +xref: EC:2.7.4.13 +xref: MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN +xref: RHEA:11216 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0047508 +name: (R)-2-methylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O." [EC:4.2.1.35, RHEA:22332] +synonym: "(-)-citramalate hydro-lyase activity" RELATED [EC:4.2.1.35] +synonym: "(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)" RELATED [EC:4.2.1.35] +synonym: "(R)-2-methylmalate hydro-lyase activity" RELATED [EC:4.2.1.35] +synonym: "citraconase activity" RELATED [EC:4.2.1.35] +synonym: "citraconate hydratase activity" RELATED [EC:4.2.1.35] +synonym: "citramalate hydro-lyase activity" RELATED [EC:4.2.1.35] +xref: EC:4.2.1.35 +xref: KEGG_REACTION:R03896 +xref: MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN +xref: RHEA:22332 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047509 +name: (R)-dehydropantoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH." [EC:1.2.1.33, RHEA:19349] +synonym: "(R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.2.1.33] +synonym: "D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity" RELATED [EC:1.2.1.33] +synonym: "D-aldopantoate dehydrogenase activity" RELATED [EC:1.2.1.33] +xref: EC:1.2.1.33 +xref: KEGG_REACTION:R03198 +xref: MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN +xref: RHEA:19349 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047510 +name: (S)-2-methylmalate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-citramalate = H(2)O + mesaconate." [EC:4.2.1.34, RHEA:13529] +synonym: "(+)-citramalate hydro-lyase activity" RELATED [EC:4.2.1.34] +synonym: "(+)-citramalic hydro-lyase activity" RELATED [EC:4.2.1.34] +synonym: "(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming)" RELATED [EC:4.2.1.34] +synonym: "(S)-2-methylmalate hydro-lyase activity" RELATED [EC:4.2.1.34] +synonym: "citramalate dehydratase activity" RELATED [EC:4.2.1.34] +synonym: "L-citramalate hydrolase activity" RELATED [EC:4.2.1.34] +synonym: "mesaconase activity" RELATED [EC:4.2.1.34] +synonym: "mesaconate hydratase activity" RELATED [EC:4.2.1.34] +synonym: "mesaconate mesaconase activity" RELATED [EC:4.2.1.34] +xref: EC:4.2.1.34 +xref: KEGG_REACTION:R03693 +xref: MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN +xref: RHEA:13529 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047511 +name: (S)-methylmalonyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate." [EC:3.1.2.17, RHEA:17345] +synonym: "D-methylmalonyl-coenzyme A hydrolase activity" RELATED [EC:3.1.2.17] +xref: EC:3.1.2.17 +xref: KEGG_REACTION:R02764 +xref: MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN +xref: RHEA:17345 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047512 +name: (S,S)-butanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH." [EC:1.1.1.76, RHEA:12184] +synonym: "(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.76] +synonym: "L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)" RELATED [EC:1.1.1.76] +synonym: "L-BDH" RELATED [EC:1.1.1.76] +synonym: "L-butanediol dehydrogenase activity" RELATED [EC:1.1.1.76] +xref: EC:1.1.1.76 +xref: KEGG_REACTION:R03707 +xref: MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN +xref: RHEA:12184 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047513 +name: 1,2-alpha-L-fucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside." [EC:3.2.1.63, MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN] +synonym: "2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity" RELATED [EC:3.2.1.63] +synonym: "almond emulsin fucosidase activity" RELATED [EC:3.2.1.63] +synonym: "almond emulsin fucosidase II activity" NARROW [EC:3.2.1.63] +synonym: "alpha-(1->2)-L-fucosidase activity" RELATED [EC:3.2.1.63] +xref: EC:3.2.1.63 +xref: MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN +xref: RHEA:10816 +is_a: GO:0004560 ! alpha-L-fucosidase activity + +[Term] +id: GO:0047514 +name: 1,3-beta-D-glucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin." [EC:2.4.1.97, MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN] +synonym: "1,3-beta-D-glucan:orthophosphate glucosyltransferase activity" RELATED [EC:2.4.1.97] +synonym: "1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.97] +synonym: "1,3-beta-glucan phosphorylase activity" EXACT [] +synonym: "laminarin phosphorylase activity" RELATED [EC:2.4.1.97] +synonym: "laminarin phosphoryltransferase activity" RELATED [EC:2.4.1.97] +xref: EC:2.4.1.97 +xref: MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047515 +name: 1,3-beta-oligoglucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.30, MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN] +synonym: "1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.30] +synonym: "beta-1,3-oligoglucan phosphorylase activity" RELATED [EC:2.4.1.30] +synonym: "beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity" RELATED [EC:2.4.1.30] +xref: EC:2.4.1.30 +xref: MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN +xref: RHEA:16041 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047516 +name: 1,3-propanediol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+." [EC:1.1.1.202, MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN] +synonym: "1,3-PD:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.202] +synonym: "1,3-propanediol oxidoreductase activity" RELATED [EC:1.1.1.202] +synonym: "1,3-propanediol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.202] +synonym: "3-hydroxypropionaldehyde reductase activity" RELATED [EC:1.1.1.202] +synonym: "propane-1,3-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.202] +xref: EC:1.1.1.202 +xref: MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN +xref: RHEA:23188 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047517 +name: 1,4-beta-D-xylan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1)." [EC:2.4.2.24, MetaCyc:1\,4-BETA-D-XYLAN-SYNTHASE-RXN] +synonym: "1,4-beta-xylan synthase activity" RELATED [EC:2.4.2.24] +synonym: "UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.24] +synonym: "uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity" RELATED [EC:2.4.2.24] +synonym: "xylan synthase activity" RELATED [EC:2.4.2.24] +synonym: "xylan synthetase activity" RELATED [EC:2.4.2.24] +xref: EC:2.4.2.24 +xref: MetaCyc:RXN-9104 +xref: RHEA:15289 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047518 +name: 1-methyladenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose." [EC:3.2.2.13, RHEA:12865] +synonym: "1-methyladenosine hydrolase activity" RELATED [EC:3.2.2.13] +synonym: "1-methyladenosine ribohydrolase activity" RELATED [EC:3.2.2.13] +xref: EC:3.2.2.13 +xref: KEGG_REACTION:R03885 +xref: MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN +xref: RHEA:12865 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047519 +name: quinate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol." [RHEA:23672] +synonym: "NAD(P)-independent quinate dehydrogenase activity" RELATED [EC:1.1.5.8] +synonym: "quinate:pyrroloquinoline-quinone 5-oxidoreductase activity" RELATED [EC:1.1.5.8] +synonym: "quinate:quinone 3-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.8] +xref: EC:1.1.5.8 +xref: KEGG_REACTION:R01873 +xref: MetaCyc:1.1.99.25-RXN +xref: RHEA:23672 +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0047520 +name: 11-cis-retinyl-palmitate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate." [EC:3.1.1.63, RHEA:19697] +synonym: "11-cis-retinol palmitate esterase activity" RELATED [EC:3.1.1.63] +synonym: "11-cis-retinyl-palmitate acylhydrolase activity" RELATED [EC:3.1.1.63] +synonym: "RPH" RELATED [EC:3.1.1.63] +xref: EC:3.1.1.63 +xref: KEGG_REACTION:R03049 +xref: MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN +xref: Reactome:R-HSA-2465941 "A REH hydrolyses 11cRE to 11cROL" +xref: RHEA:19697 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047521 +name: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH." [EC:1.1.1.238, RHEA:21424] +synonym: "12-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] +synonym: "12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" BROAD [EC:1.1.1.238] +synonym: "12beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.238] +synonym: "12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity" BROAD [EC:1.1.1.238] +xref: EC:1.1.1.238 +xref: KEGG_REACTION:R03495 +xref: MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN +xref: RHEA:21424 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047522 +name: 15-oxoprostaglandin 13-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+." [EC:1.3.1.48, KEGG_REACTION:R04556, KEGG_REACTION:R04557, MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN] +comment: Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'. +synonym: "(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity" RELATED [EC:1.3.1.48] +xref: EC:1.3.1.48 +xref: KEGG_REACTION:R04556 +xref: KEGG_REACTION:R04557 +xref: MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047524 +name: 16-hydroxysteroid epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid." [EC:5.1.99.2, MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN] +synonym: "16-hydroxysteroid 16-epimerase activity" RELATED [EC:5.1.99.2] +xref: EC:5.1.99.2 +xref: MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN +xref: RHEA:15829 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0047525 +name: 2'-hydroxydaidzein reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+." [EC:1.3.1.51, MetaCyc:2'-HYDROXYDAIDZEIN-REDUCTASE-RXN] +synonym: "2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.3.1.51] +synonym: "2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity" RELATED [EC:1.3.1.51] +synonym: "2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.3.1.51] +synonym: "HDR activity" RELATED [EC:1.3.1.51] +synonym: "NADPH:2'-hydroxydaidzein oxidoreductase activity" RELATED [EC:1.3.1.51] +xref: EC:1.3.1.51 +xref: MetaCyc:RXN-4502 +xref: RHEA:17145 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047526 +name: 2'-hydroxyisoflavone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+." [EC:1.3.1.45, MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN] +synonym: "2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity" RELATED [EC:1.3.1.45] +synonym: "isoflavone reductase activity" RELATED [EC:1.3.1.45] +synonym: "NADPH:2'-hydroxyisoflavone oxidoreductase activity" RELATED [EC:1.3.1.45] +synonym: "vestitone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.45] +xref: EC:1.3.1.45 +xref: MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN +xref: RHEA:22560 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047527 +name: 2,3-dihydroxybenzoate-serine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine." [EC:6.3.2.14, MetaCyc:1\,3-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN] +synonym: "2,3-dihydroxybenzoate:L-serine ligase activity" RELATED [EC:6.3.2.14] +synonym: "2,3-dihydroxybenzoylserine synthetase activity" RELATED [EC:6.3.2.14] +synonym: "N-(2,3-dihydroxybenzoyl)-serine synthetase activity" RELATED [EC:6.3.2.14] +xref: EC:6.3.2.14 +xref: MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN +xref: RHEA:30571 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047528 +name: 2,3-dihydroxyindole 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+)." [EC:1.13.11.23, RHEA:19445] +synonym: "2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity" RELATED [EC:1.13.11.23] +xref: EC:1.13.11.23 +xref: KEGG_REACTION:R00983 +xref: MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN +xref: RHEA:19445 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047529 +name: 2,3-dimethylmalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate." [EC:4.1.3.32, RHEA:10472] +synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)" RELATED [EC:4.1.3.32] +synonym: "(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity" RELATED [EC:4.1.3.32] +synonym: "2,3-dimethylmalate pyruvate-lyase activity" RELATED [EC:4.1.3.32] +xref: EC:4.1.3.32 +xref: KEGG_REACTION:R01355 +xref: MetaCyc:23-DIMETHYLMALATE-LYASE-RXN +xref: RHEA:10472 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047530 +name: 2,4-diaminopentanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+." [EC:1.4.1.12, MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN] +synonym: "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.12] +synonym: "2,4-diaminopentanoic acid C4 dehydrogenase activity" RELATED [EC:1.4.1.12] +xref: EC:1.4.1.12 +xref: MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047531 +name: 2,5-diaminovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate." [EC:2.6.1.8, RHEA:16017] +synonym: "2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.8] +synonym: "2,5-diaminovalerate aminotransferase activity" EXACT [] +synonym: "diamino acid aminotransferase activity" RELATED [EC:2.6.1.8] +synonym: "diamino-acid aminotransferase activity" RELATED [EC:2.6.1.8] +synonym: "diamino-acid transaminase activity" RELATED [EC:2.6.1.8] +xref: EC:2.6.1.8 +xref: KEGG_REACTION:R03248 +xref: MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN +xref: RHEA:16017 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047532 +name: 2,5-dioxopiperazine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine." [EC:3.5.2.13, RHEA:21808] +synonym: "2,5-dioxopiperazine amidohydrolase activity" RELATED [EC:3.5.2.13] +synonym: "cyclo(Gly-Gly) hydrolase activity" RELATED [EC:3.5.2.13] +synonym: "cyclo(glycylglycine) hydrolase activity" RELATED [EC:3.5.2.13] +xref: EC:3.5.2.13 +xref: KEGG_REACTION:R03810 +xref: MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN +xref: RHEA:21808 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047533 +name: 2,5-dioxovalerate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+." [EC:1.2.1.26, MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN] +synonym: "2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity" RELATED [EC:1.2.1.26] +synonym: "2-oxoglutarate semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.26] +synonym: "alpha-ketoglutaric semialdehyde dehydrogenase activity" RELATED [EC:1.2.1.26] +xref: EC:1.2.1.26 +xref: MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN +xref: RHEA:11296 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047534 +name: 2-acetolactate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate." [EC:5.4.99.3, MetaCyc:2-ACETOLACTATE-MUTASE-RXN] +synonym: "2-acetolactate methylmutase activity" RELATED [EC:5.4.99.3] +synonym: "acetohydroxy acid isomerase activity" BROAD [EC:5.4.99.3] +synonym: "acetolactate mutase activity" RELATED [EC:5.4.99.3] +xref: EC:5.4.99.3 +xref: MetaCyc:2-ACETOLACTATE-MUTASE-RXN +xref: RHEA:16361 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047535 +name: 2-alkyn-1-ol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH." [EC:1.1.1.165, RHEA:19101] +synonym: "2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.165] +xref: EC:1.1.1.165 +xref: KEGG_REACTION:R03963 +xref: MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN +xref: RHEA:19101 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047536 +name: 2-aminoadipate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate." [EC:2.6.1.39, RHEA:12601] +synonym: "2-aminoadipate aminotransferase activity" EXACT [] +synonym: "2-aminoadipic aminotransferase activity" RELATED [EC:2.6.1.39] +synonym: "alpha-aminoadipate aminotransferase activity" RELATED [EC:2.6.1.39] +synonym: "glutamate-alpha-ketoadipate transaminase activity" RELATED [EC:2.6.1.39] +synonym: "glutamic-ketoadipic transaminase activity" RELATED [EC:2.6.1.39] +synonym: "L-2-aminoadipate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.39] +xref: EC:2.6.1.39 +xref: KEGG_REACTION:R01939 +xref: MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-508561 "alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate" +xref: Reactome:R-HSA-70952 "alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate" +xref: RHEA:12601 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047537 +name: 2-aminohexanoate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate." [EC:2.6.1.67, MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN] +synonym: "2-aminohexanoate aminotransferase activity" EXACT [] +synonym: "L-2-aminohexanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.67] +synonym: "leucine L-norleucine: 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.67] +synonym: "norleucine (leucine) aminotransferase activity" RELATED [EC:2.6.1.67] +synonym: "norleucine aminotransferase activity" RELATED [EC:2.6.1.67] +synonym: "norleucine transaminase activity" RELATED [EC:2.6.1.67] +xref: EC:2.6.1.67 +xref: MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN +xref: RHEA:23600 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047538 +name: 2-carboxy-D-arabinitol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate." [EC:3.1.3.63, RHEA:17837] +synonym: "2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.63] +synonym: "2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.63] +synonym: "2-carboxyarabinitol 1-phosphatase activity" RELATED [EC:3.1.3.63] +xref: EC:3.1.3.63 +xref: KEGG_REACTION:R04167 +xref: MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN +xref: RHEA:17837 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047539 +name: 2-deoxyglucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol." [EC:3.2.1.112, MetaCyc:2-DEOXYGLUCOSIDASE-RXN] +synonym: "2-deoxy-alpha-D-glucosidase activity" RELATED [EC:3.2.1.112] +synonym: "2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity" RELATED [EC:3.2.1.112] +synonym: "2-deoxy-alpha-glucosidase activity" RELATED [EC:3.2.1.112] +xref: EC:3.2.1.112 +xref: MetaCyc:2-DEOXYGLUCOSIDASE-RXN +xref: RHEA:15317 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0047540 +name: 2-enoate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+." [EC:1.3.1.31, MetaCyc:2-ENOATE-REDUCTASE-RXN] +synonym: "butanoate:NAD+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.31] +synonym: "enoate reductase activity" RELATED [EC:1.3.1.31] +xref: EC:1.3.1.31 +xref: MetaCyc:2-ENOATE-REDUCTASE-RXN +xref: RHEA:10200 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047541 +name: 2-furoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.31, RHEA:19269] +synonym: "2-furoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.31] +synonym: "2-furoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.31] +xref: EC:6.2.1.31 +xref: KEGG_REACTION:R02986 +xref: MetaCyc:2-FUROATE--COA-LIGASE-RXN +xref: RHEA:19269 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047542 +name: 2-furoyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+)." [EC:1.3.99.8, RHEA:21480] +synonym: "2-furoyl coenzyme A dehydrogenase activity" RELATED [EC:1.3.99.8] +synonym: "2-furoyl coenzyme A hydroxylase activity" RELATED [EC:1.3.99.8] +synonym: "2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.8] +synonym: "2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)" RELATED [EC:1.3.99.8] +synonym: "furoyl-CoA hydroxylase activity" RELATED [EC:1.3.99.8] +xref: EC:1.3.99.8 +xref: KEGG_REACTION:R02987 +xref: MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN +xref: RHEA:21480 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047543 +name: 2-hexadecenal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH." [EC:1.3.1.27, RHEA:12444] +synonym: "hexadecanal: NADP+ oxidoreductase activity" RELATED [EC:1.3.1.27] +synonym: "hexadecanal:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.27] +xref: EC:1.3.1.27 +xref: KEGG_REACTION:R02463 +xref: MetaCyc:2-HEXADECENAL-REDUCTASE-RXN +xref: RHEA:12444 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047544 +name: 2-hydroxybiphenyl 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+)." [RHEA:11996] +synonym: "2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.44] +xref: EC:1.14.13.44 +xref: KEGG_REACTION:R03964 +xref: MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN +xref: RHEA:11996 +xref: UM-BBD_reactionID:r1423 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047545 +name: 2-hydroxyglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] +synonym: "(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase" RELATED [EC:1.1.99.2] +synonym: "(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase" RELATED [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate dehydrogenase (NAD+ specific)" NARROW [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate dehydrogenase activity" RELATED [EC:1.1.99.2] +synonym: "alpha-hydroxyglutarate oxidoreductase activity" RELATED [EC:1.1.99.2] +synonym: "hydroxyglutaric dehydrogenase activity" RELATED [EC:1.1.99.2] +synonym: "L-alpha-hydroxyglutarate dehydrogenase activity" RELATED [EC:1.1.99.2] +synonym: "L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase" NARROW [EC:1.1.99.2] +xref: EC:1.1.99.2 +xref: MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-880050 "(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2" +xref: RHEA:21252 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047546 +name: 2-hydroxypyridine 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O." [EC:1.14.99.26, RHEA:16973] +synonym: "2-hydroxypyridine oxygenase activity" RELATED [EC:1.14.99.26] +synonym: "2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.99.26] +xref: EC:1.14.99.26 +xref: KEGG_REACTION:R03206 +xref: MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN +xref: RHEA:16973 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047547 +name: 2-methylcitrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O." [EC:4.2.1.79, RHEA:17725] +synonym: "(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]" RELATED [EC:4.2.1.79] +synonym: "2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity" RELATED [EC:4.2.1.79] +synonym: "2-methylcitrate hydro-lyase activity" RELATED [EC:4.2.1.79] +synonym: "prpD" RELATED [EC:4.2.1.79] +xref: EC:4.2.1.79 +xref: KEGG_REACTION:R04424 +xref: MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN +xref: RHEA:17725 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047548 +name: 2-methyleneglutarate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate." [EC:5.4.99.4, RHEA:13793] +synonym: "2-methyleneglutarate carboxy-methylenemethylmutase activity" RELATED [EC:5.4.99.4] +synonym: "alpha-methyleneglutarate mutase activity" RELATED [EC:5.4.99.4] +xref: EC:5.4.99.4 +xref: KEGG_REACTION:R03908 +xref: MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN +xref: RHEA:13793 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047549 +name: 2-nitrophenol 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite." [EC:1.14.13.31, RHEA:19457] +synonym: "2-nitrophenol oxygenase activity" RELATED [EC:1.14.13.31] +synonym: "2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)" RELATED [EC:1.14.13.31] +synonym: "nitrophenol oxygenase activity" BROAD [EC:1.14.13.31] +xref: EC:1.14.13.31 +xref: KEGG_REACTION:R00828 +xref: MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN +xref: RHEA:19457 +xref: UM-BBD_reactionID:r1494 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047550 +name: 2-oxoadipate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH." [EC:1.1.1.172, RHEA:14793] +synonym: "2-hydroxyadipate:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.172] +synonym: "2-ketoadipate reductase activity" RELATED [EC:1.1.1.172] +synonym: "alpha-ketoadipate reductase activity" RELATED [EC:1.1.1.172] +xref: EC:1.1.1.172 +xref: KEGG_REACTION:R01932 +xref: MetaCyc:2-OXOADIPATE-REDUCTASE-RXN +xref: RHEA:14793 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047551 +name: 2-oxoaldehyde dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+." [EC:1.2.1.23, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN] +synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.23] +synonym: "2-oxoaldehyde dehydrogenase (NAD+)" RELATED [EC:1.2.1.23] +synonym: "2-oxoaldehyde:NAD+ 2-oxidoreductase activity" RELATED [EC:1.2.1.23] +synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.23] +synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.23] +synonym: "NAD-dependent alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.23] +synonym: "NAD-linked alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.23] +xref: EC:1.2.1.23 +xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN +xref: RHEA:22276 +xref: Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+) +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0047552 +name: 2-oxoaldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+." [EC:1.2.1.49, MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN] +synonym: "2-ketoaldehyde dehydrogenase" BROAD [EC:1.2.1.49] +synonym: "2-oxoaldehyde:NADP+ 2-oxidoreductase activity" RELATED [EC:1.2.1.49] +synonym: "alpha-ketoaldehyde dehydrogenase activity" BROAD [EC:1.2.1.49] +synonym: "methylglyoxal dehydrogenase activity" BROAD [EC:1.2.1.49] +synonym: "NADP-dependent alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.49] +synonym: "NADP-linked alpha-ketoaldehyde dehydrogenase activity" RELATED [EC:1.2.1.49] +xref: EC:1.2.1.49 +xref: MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:18129 +is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity + +[Term] +id: GO:0047553 +name: 2-oxoglutarate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.3, MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN] +synonym: "2-ketoglutarate ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3] +synonym: "2-oxoglutarate ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)" RELATED [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating)" RELATED [EC:1.2.7.3] +synonym: "2-oxoglutarate:ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3] +synonym: "alpha-ketoglutarate synthase activity" RELATED [EC:1.2.7.3] +synonym: "alpha-ketoglutarate-ferredoxin oxidoreductase activity" RELATED [EC:1.2.7.3] +synonym: "KGOR activity" RELATED [EC:1.2.7.3] +xref: EC:1.2.7.3 +xref: MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN +xref: RHEA:17297 +is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047554 +name: 2-pyrone-4,6-dicarboxylate lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+)." [EC:3.1.1.57, RHEA:10644] +synonym: "2-pyrone-4,6-dicarboxylate lactonohydrolase activity" RELATED [EC:3.1.1.57] +xref: EC:3.1.1.57 +xref: KEGG_REACTION:R04277 +xref: MetaCyc:RXN-2462 +xref: RHEA:10644 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047555 +name: 3',5'-cyclic-GMP phosphodiesterase activity +namespace: molecular_function +alt_id: GO:0004116 +def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate." [EC:3.1.4.35, MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN] +synonym: "3',5' cyclic-GMP phosphodiesterase activity" EXACT [] +synonym: "3',5'-cyclic-GMP 5'-nucleotidohydrolase activity" RELATED [EC:3.1.4.35] +synonym: "cGMP phosphodiesterase activity" EXACT [] +synonym: "cGMP-PDE" RELATED [EC:3.1.4.35] +synonym: "cGMP-specific phosphodiesterase activity" EXACT [] +synonym: "cyclic 3',5'-GMP phosphodiesterase activity" RELATED [EC:3.1.4.35] +synonym: "cyclic GMP phosphodiesterase activity" EXACT [] +synonym: "cyclic guanosine 3',5'-monophosphate phosphodiesterase activity" RELATED [EC:3.1.4.35] +synonym: "cyclic guanosine 3',5'-phosphate phosphodiesterase activity" RELATED [EC:3.1.4.35] +synonym: "guanosine cyclic 3',5'-phosphate phosphodiesterase activity" EXACT [] +xref: EC:3.1.4.35 +xref: MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN +xref: Reactome:R-HSA-4086392 "PDE6 hydrolyses cGMP to GMP" +xref: Reactome:R-HSA-418456 "cGMP is degraded by PDEs" +xref: Reactome:R-HSA-74059 "PDE6 hydrolyses cGMP to GMP" +xref: RHEA:16957 +is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity + +[Term] +id: GO:0047556 +name: 3,4-dihydroxyphthalate decarboxylase activity +namespace: molecular_function +alt_id: GO:0034913 +def: "Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2)." [EC:4.1.1.69, RHEA:18601] +synonym: "3,4-dihydroxyphthalate 2-decarboxylase activity" EXACT [] +synonym: "3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" RELATED [EC:4.1.1.69] +synonym: "3,4-dihydroxyphthalate carboxy-lyase activity" RELATED [EC:4.1.1.69] +xref: EC:4.1.1.69 +xref: KEGG_REACTION:R01634 +xref: MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN +xref: RHEA:18601 +xref: UM-BBD_reactionID:r1447 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047557 +name: 3-aci-nitropropanoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite." [EC:1.7.3.5, RHEA:22372] +synonym: "3-aci-nitropropanoate:oxygen oxidoreductase activity" RELATED [EC:1.7.3.5] +synonym: "propionate-3-nitronate oxidase activity" RELATED [EC:1.7.3.5] +xref: EC:1.7.3.5 +xref: KEGG_REACTION:R01609 +xref: MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN +xref: RHEA:22372 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047558 +name: 3-cyanoalanine hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+)." [EC:4.2.1.65, RHEA:15385] +synonym: "beta-CNA nitrilase activity" RELATED [EC:4.2.1.65] +synonym: "beta-CNAla hydrolase activity" RELATED [EC:4.2.1.65] +synonym: "beta-cyanoalanine hydratase activity" RELATED [EC:4.2.1.65] +synonym: "beta-cyanoalanine hydrolase activity" RELATED [EC:4.2.1.65] +synonym: "L-asparagine hydro-lyase (3-cyanoalanine-forming)" RELATED [EC:4.2.1.65] +synonym: "L-asparagine hydro-lyase activity" RELATED [EC:4.2.1.65] +xref: EC:4.2.1.65 +xref: KEGG_REACTION:R01267 +xref: MetaCyc:3-CYANOALANINE-HYDRATASE-RXN +xref: RHEA:15385 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047559 +name: 3-dehydro-L-gulonate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+." [EC:1.1.1.130, MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN] +synonym: "2,3-diketo-L-gulonate reductase activity" RELATED [EC:1.1.1.130] +synonym: "3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.130] +synonym: "3-keto-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.130] +synonym: "3-ketogulonate dehydrogenase activity" RELATED [EC:1.1.1.130] +xref: EC:1.1.1.130 +xref: MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047560 +name: 3-dehydrosphinganine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH." [EC:1.1.1.102, RHEA:22640] +synonym: "3-ketosphinganine reductase activity" RELATED [EC:1.1.1.102] +synonym: "3-oxosphinganine reductase activity" RELATED [EC:1.1.1.102] +synonym: "3-oxosphinganine:NADPH oxidoreductase activity" RELATED [EC:1.1.1.102] +synonym: "D-3-dehydrosphinganine reductase activity" RELATED [EC:1.1.1.102] +synonym: "D-3-oxosphinganine reductase activity" RELATED [EC:1.1.1.102] +synonym: "D-3-oxosphinganine:B-NADPH oxidoreductase activity" RELATED [EC:1.1.1.102] +synonym: "D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.102] +synonym: "DSR activity" RELATED [EC:1.1.1.102] +synonym: "KTS reductase activity" RELATED [EC:1.1.1.102] +xref: EC:1.1.1.102 +xref: KEGG_REACTION:R02978 +xref: MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN +xref: Reactome:R-HSA-428123 "3-ketosphinganine + NADPH + H+ => sphinganine + NADP+" +xref: RHEA:22640 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047561 +name: 3-hydroxyanthranilate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2)." [EC:1.10.3.5, RHEA:17245] +synonym: "3-hydroxyanthranilate:oxygen oxidoreductase activity" RELATED [EC:1.10.3.5] +synonym: "3-hydroxyanthranilic acid oxidase activity" RELATED [EC:1.10.3.5] +xref: EC:1.10.3.5 +xref: KEGG_REACTION:R02666 +xref: MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN +xref: RHEA:17245 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0047562 +name: 3-hydroxyaspartate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate." [EC:4.1.3.14, RHEA:14377] +synonym: "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity" RELATED [EC:4.1.3.14] +synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)" RELATED [EC:4.1.3.14] +synonym: "erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity" RELATED [EC:4.1.3.14] +synonym: "erythro-beta-hydroxyaspartate aldolase activity" RELATED [EC:4.1.3.14] +synonym: "erythro-beta-hydroxyaspartate glycine-lyase activity" RELATED [EC:4.1.3.14] +xref: EC:4.1.3.14 +xref: KEGG_REACTION:R00478 +xref: MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN +xref: RHEA:14377 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047563 +name: 3-hydroxybenzoate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O." [EC:1.14.99.23, RHEA:14193] +synonym: "3-HBA-2-hydroxylase activity" RELATED [EC:1.14.99.23] +synonym: "3-hydroxybenzoate 2-hydroxylase activity" EXACT [] +synonym: "3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.99.23] +xref: EC:1.14.99.23 +xref: KEGG_REACTION:R01508 +xref: MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN +xref: RHEA:14193 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047564 +name: 3-hydroxycyclohexanone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione." [EC:1.1.99.26, RHEA:15905] +synonym: "3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.26] +xref: EC:1.1.99.26 +xref: KEGG_REACTION:R03212 +xref: MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN +xref: RHEA:15905 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047565 +name: 3-hydroxypropionate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH." [EC:1.1.1.59, RHEA:13357] +synonym: "3-hydroxypropanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.59] +xref: EC:1.1.1.59 +xref: KEGG_REACTION:R01608 +xref: MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN +xref: RHEA:13357 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047566 +name: 3-ketovalidoxylamine C-N-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+)." [EC:4.3.3.1, RHEA:22768] +synonym: "3-ketovalidoxylamine A C-N-lyase activity" RELATED [EC:4.3.3.1] +synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]" RELATED [EC:4.3.3.1] +synonym: "4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity" RELATED [EC:4.3.3.1] +synonym: "p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity" RELATED [EC:4.3.3.1] +xref: EC:4.3.3.1 +xref: KEGG_REACTION:R04367 +xref: MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN +xref: RHEA:22768 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0047567 +name: 3-methyleneoxindole reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH." [EC:1.3.1.17, RHEA:20257] +synonym: "3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.17] +synonym: "3-methyloxindole:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.17] +xref: EC:1.3.1.17 +xref: KEGG_REACTION:R03930 +xref: MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN +xref: RHEA:20257 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047568 +name: 3-oxo-5-beta-steroid 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor." [EC:1.3.99.6, MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN] +synonym: "3-oxo-5beta-steroid 4-dehydrogenase activity" RELATED [EC:1.3.99.6] +synonym: "3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity" RELATED [EC:1.3.99.6] +synonym: "3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity" RELATED [EC:1.3.99.6] +synonym: "delta4-3-ketosteroid 5-beta-reductase activity" RELATED [EC:1.3.99.6] +xref: EC:1.3.99.6 +xref: MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN +xref: RHEA:24172 +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047569 +name: 3-oxoadipate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA." [EC:2.8.3.6, MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN] +synonym: "3-oxoadipate coenzyme A-transferase activity" RELATED [EC:2.8.3.6] +synonym: "3-oxoadipate succinyl-CoA transferase activity" RELATED [EC:2.8.3.6] +synonym: "beta-ketoadipate:succinyl-CoA transferase activity" RELATED [EC:2.8.3.6] +synonym: "succinyl-CoA:3-oxoadipate CoA-transferase activity" RELATED [EC:2.8.3.6] +xref: EC:2.8.3.6 +xref: MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN +xref: RHEA:12048 +xref: UM-BBD_reactionID:r1050 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047570 +name: 3-oxoadipate enol-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate." [EC:3.1.1.24, MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN] +synonym: "3-ketoadipate enol-lactonase activity" RELATED [EC:3.1.1.24] +synonym: "3-oxoadipic enol-lactone hydrolase activity" RELATED [EC:3.1.1.24] +synonym: "4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity" RELATED [EC:3.1.1.24] +synonym: "beta-ketoadipate enol-lactone hydrolase activity" RELATED [EC:3.1.1.24] +synonym: "beta-ketoadipic enol-lactone hydrolase activity" RELATED [EC:3.1.1.24] +synonym: "carboxymethylbutenolide lactonase activity" RELATED [EC:3.1.1.24] +xref: EC:3.1.1.24 +xref: MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN +xref: RHEA:10184 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047571 +name: 3-oxosteroid 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor." [EC:1.3.99.4, MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN] +synonym: "1-ene-dehydrogenase activity" RELATED [EC:1.3.99.4] +synonym: "3-ketosteroid-1-en-dehydrogenase activity" RELATED [EC:1.3.99.4] +synonym: "3-ketosteroid-delta1-dehydrogenase activity" RELATED [EC:1.3.99.4] +synonym: "3-oxosteroid delta1-dehydrogenase activity" RELATED [EC:1.3.99.4] +synonym: "3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity" RELATED [EC:1.3.99.4] +synonym: "3-oxosteroid:(acceptor) delta1-oxidoreductase activity" RELATED [EC:1.3.99.4] +synonym: "3-oxosteroid:acceptor delta1-oxidoreductase activity" RELATED [EC:1.3.99.4] +synonym: "4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity" RELATED [EC:1.3.99.4] +synonym: "delta1-dehydrogenase activity" RELATED [EC:1.3.99.4] +synonym: "delta1-steroid reductase activity" RELATED [EC:1.3.99.4] +xref: EC:1.3.99.4 +xref: MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN +xref: RHEA:13329 +xref: UM-BBD_enzymeID:e0712 +is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047572 +name: 3-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.38, RHEA:12412] +synonym: "3-PGA phosphatase activity" RELATED [EC:3.1.3.38] +synonym: "D-3-phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.38] +synonym: "D-glycerate-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.38] +xref: EC:3.1.3.38 +xref: KEGG_REACTION:R01511 +xref: MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN +xref: RHEA:12412 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047573 +name: 4-acetamidobutyrate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate." [EC:3.5.1.63, MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN] +synonym: "4-acetamidobutanoate amidohydrolase activity" RELATED [EC:3.5.1.63] +xref: EC:3.5.1.63 +xref: MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN +xref: RHEA:15897 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047574 +name: 4-acetamidobutyryl-CoA deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate." [EC:3.5.1.51, RHEA:22928] +synonym: "4-acetamidobutanoyl-CoA amidohydrolase activity" RELATED [EC:3.5.1.51] +synonym: "aminobutyryl-CoA thiolesterase activity" RELATED [EC:3.5.1.51] +synonym: "deacetylase-thiolesterase activity" RELATED [EC:3.5.1.51] +xref: EC:3.5.1.51 +xref: KEGG_REACTION:R04056 +xref: MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN +xref: RHEA:22928 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047575 +name: 4-carboxymuconolactone decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2)." [EC:4.1.1.44, RHEA:23348] +synonym: "4-carboxymonolactone carboxy-lyase activity" RELATED [EC:4.1.1.44] +synonym: "4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)" RELATED [EC:4.1.1.44] +synonym: "4-carboxymuconolactone carboxy-lyase activity" RELATED [EC:4.1.1.44] +synonym: "gamma-4-carboxymuconolactone decarboxylase activity" RELATED [EC:4.1.1.44] +xref: EC:4.1.1.44 +xref: KEGG_REACTION:R03470 +xref: MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN +xref: RHEA:23348 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047576 +name: 4-chlorobenzoate dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+)." [EC:3.8.1.6, RHEA:23440] +synonym: "4-chlorobenzoate chlorohydrolase activity" RELATED [EC:3.8.1.6] +synonym: "halobenzoate dehalogenase activity" RELATED [EC:3.8.1.6] +xref: EC:3.8.1.6 +xref: KEGG_REACTION:R01307 +xref: MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN +xref: RHEA:23440 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0047577 +name: 4-hydroxybutyrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde." [EC:1.1.1.61, RHEA:23948] +synonym: "4-hydroxybutanoate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.61] +synonym: "gamma-hydroxybutyrate dehydrogenase activity" RELATED [EC:1.1.1.61] +xref: EC:1.1.1.61 +xref: KEGG_REACTION:R01644 +xref: MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN +xref: RHEA:23948 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047578 +name: 4-hydroxyglutamate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate." [EC:2.6.1.23, MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN] +synonym: "4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.23] +synonym: "4-hydroxyglutamate aminotransferase activity" EXACT [] +xref: EC:2.6.1.23 +xref: MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-6784393 "PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)" +xref: RHEA:10480 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047579 +name: 4-hydroxymandelate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2)." [EC:1.1.3.19, RHEA:15833] +synonym: "(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.19] +synonym: "L-4-hydroxymandelate oxidase (decarboxylating)" RELATED [EC:1.1.3.19] +xref: EC:1.1.3.19 +xref: KEGG_REACTION:R02673 +xref: MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN +xref: RHEA:15833 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047580 +name: 4-hydroxyproline epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline." [EC:5.1.1.8, RHEA:21152] +synonym: "4-hydroxyproline 2-epimerase activity" RELATED [EC:5.1.1.8] +synonym: "hydroxyproline 2-epimerase activity" RELATED [EC:5.1.1.8] +synonym: "hydroxyproline epimerase activity" RELATED [EC:5.1.1.8] +synonym: "L-hydroxyproline epimerase activity" RELATED [EC:5.1.1.8] +xref: EC:5.1.1.8 +xref: KEGG_REACTION:R03296 +xref: MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN +xref: RHEA:21152 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0047581 +name: 4-methyleneglutamate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+)." [EC:6.3.1.7, RHEA:13853] +synonym: "4-methylene-L-glutamate:ammonia ligase (AMP-forming)" RELATED [EC:6.3.1.7] +synonym: "4-methyleneglutamine synthetase activity" RELATED [EC:6.3.1.7] +xref: EC:6.3.1.7 +xref: KEGG_REACTION:R02711 +xref: MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN +xref: RHEA:13853 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047582 +name: 4-methyleneglutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+)." [EC:3.5.1.67, RHEA:14741] +synonym: "4-methylene-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.67] +synonym: "4-methyleneglutamine amidohydrolase activity" RELATED [EC:3.5.1.67] +synonym: "4-methyleneglutamine deamidase activity" RELATED [EC:3.5.1.67] +xref: EC:3.5.1.67 +xref: KEGG_REACTION:R02712 +xref: MetaCyc:4-METHYLENEGLUTAMINASE-RXN +xref: RHEA:14741 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047583 +name: 4-methyloxaloacetate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate." [EC:3.1.1.44, RHEA:10564] +synonym: "oxaloacetate-4-methyl-ester oxaloacetohydrolase activity" RELATED [EC:3.1.1.44] +xref: EC:3.1.1.44 +xref: KEGG_REACTION:R01144 +xref: MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN +xref: RHEA:10564 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047584 +name: 4-oxalmesaconate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O." [EC:4.2.1.83, RHEA:17401] +synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.83] +synonym: "2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" RELATED [EC:4.2.1.83] +synonym: "4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity" RELATED [EC:4.2.1.83] +synonym: "4-carboxy-2-oxohexenedioate hydratase activity" RELATED [EC:4.2.1.83] +synonym: "gamma-oxalmesaconate hydratase activity" RELATED [EC:4.2.1.83] +synonym: "oxalmesaconate hydratase activity" RELATED [EC:4.2.1.83] +xref: EC:4.2.1.83 +xref: KEGG_REACTION:R04478 +xref: MetaCyc:RXN-2463 +xref: RHEA:17401 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047585 +name: 4-pyridoxolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+)." [EC:3.1.1.27, RHEA:14301] +synonym: "4-pyridoxolactone lactonohydrolase activity" RELATED [EC:3.1.1.27] +xref: EC:3.1.1.27 +xref: KEGG_REACTION:R02992 +xref: MetaCyc:4-PYRIDOXOLACTONASE-RXN +xref: RHEA:14301 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047586 +name: 5'-acylphosphoadenosine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate." [EC:3.6.1.20, MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN] +synonym: "5'-acylphosphoadenosine acylhydrolase activity" RELATED [EC:3.6.1.20] +synonym: "5-phosphoadenosine hydrolase activity" RELATED [EC:3.6.1.20] +xref: EC:3.6.1.20 +xref: MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN +xref: RHEA:16837 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0047587 +name: 5-alpha-hydroxysteroid dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O." [EC:4.2.1.62, RHEA:22064] +synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)" RELATED [EC:4.2.1.62] +synonym: "5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity" RELATED [EC:4.2.1.62] +synonym: "5alpha-hydroxysteroid dehydratase activity" RELATED [EC:4.2.1.62] +xref: EC:4.2.1.62 +xref: KEGG_REACTION:R03675 +xref: MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN +xref: RHEA:22064 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047588 +name: 5-aminopentanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3." [EC:3.5.1.30, MetaCyc:5-AMINOPENTANAMIDASE-RXN] +synonym: "5-aminonorvaleramidase activity" RELATED [EC:3.5.1.30] +synonym: "5-aminopentanamide amidohydrolase activity" RELATED [EC:3.5.1.30] +synonym: "5-aminovaleramidase activity" RELATED [EC:3.5.1.30] +xref: EC:3.5.1.30 +xref: MetaCyc:5-AMINOPENTANAMIDASE-RXN +xref: RHEA:15677 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047589 +name: 5-aminovalerate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate." [EC:2.6.1.48, RHEA:10212] +synonym: "5-aminopentanoate:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.48] +synonym: "5-aminovalerate aminotransferase activity" EXACT [] +synonym: "delta-aminovalerate aminotransferase activity" RELATED [EC:2.6.1.48] +synonym: "delta-aminovalerate transaminase activity" RELATED [EC:2.6.1.48] +xref: EC:2.6.1.48 +xref: KEGG_REACTION:R02274 +xref: MetaCyc:VAGL-RXN +xref: RHEA:10212 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047590 +name: 5-dehydro-2-deoxygluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate." [EC:2.7.1.92, MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN] +synonym: "5-keto-2-deoxyglucono kinase (phosphorylating)" RELATED [EC:2.7.1.92] +synonym: "5-keto-2-deoxygluconokinase activity" RELATED [EC:2.7.1.92] +synonym: "ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.92] +synonym: "DKH kinase activity" RELATED [EC:2.7.1.92] +xref: EC:2.7.1.92 +xref: MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN +xref: RHEA:13497 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047591 +name: 5-hydroxypentanoate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate." [EC:2.8.3.14, RHEA:23496] +synonym: "5-hydroxyvalerate CoA-transferase activity" RELATED [EC:2.8.3.14] +synonym: "5-hydroxyvalerate coenzyme A transferase activity" RELATED [EC:2.8.3.14] +synonym: "acetyl-CoA:5-hydroxypentanoate CoA-transferase activity" RELATED [EC:2.8.3.14] +xref: EC:2.8.3.14 +xref: KEGG_REACTION:R04057 +xref: MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN +xref: RHEA:23496 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047592 +name: 5-pyridoxate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP(+)." [RHEA:11152] +comment: Formerly EC:1.14.12.5. +synonym: "5-pyridoxate oxidase activity" RELATED [EC:1.14.13.241] +xref: EC:1.14.13.241 +xref: KEGG_REACTION:R04570 +xref: MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN +xref: RHEA:11152 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047593 +name: 6-acetylglucose deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+)." [EC:3.1.1.33, RHEA:18485] +synonym: "6-acetyl-D-glucose acetylhydrolase activity" RELATED [EC:3.1.1.33] +synonym: "6-O-acetylglucose deacetylase activity" RELATED [EC:3.1.1.33] +xref: EC:3.1.1.33 +xref: KEGG_REACTION:R00327 +xref: MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN +xref: RHEA:18485 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047594 +name: 6-beta-hydroxyhyoscyamine epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate." [EC:1.14.20.13, RHEA:12797] +synonym: "(6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)" RELATED [EC:1.14.20.13] +synonym: "6beta-hydroxyhyoscyamine epoxidase activity" RELATED [EC:1.14.20.13] +synonym: "hydroxyhyoscyamine dioxygenase activity" RELATED [EC:1.14.20.13] +xref: EC:1.14.20.13 +xref: KEGG_REACTION:R03737 +xref: MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN +xref: RHEA:12797 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0047595 +name: 6-hydroxynicotinate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin." [EC:1.3.7.1, MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN] +synonym: "1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.1] +synonym: "6-hydroxynicotinic reductase activity" RELATED [EC:1.3.7.1] +synonym: "6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.1] +synonym: "6-oxotetrahydro-nicotinate dehydrogenase activity" RELATED [EC:1.3.7.1] +synonym: "6-oxotetrahydronicotinate dehydrogenase activity" RELATED [EC:1.3.7.1] +synonym: "HNA reductase activity" RELATED [EC:1.3.7.1] +xref: EC:1.3.7.1 +xref: MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN +xref: RHEA:17225 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047596 +name: 6-methylsalicylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2)." [EC:4.1.1.52, RHEA:23112] +synonym: "6-methylsalicylate carboxy-lyase (3-cresol-forming)" RELATED [EC:4.1.1.52] +synonym: "6-methylsalicylate carboxy-lyase activity" RELATED [EC:4.1.1.52] +synonym: "6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity" RELATED [EC:4.1.1.52] +synonym: "6-MSA decarboxylase activity" RELATED [EC:4.1.1.52] +xref: EC:4.1.1.52 +xref: KEGG_REACTION:R03567 +xref: MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN +xref: RHEA:23112 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047597 +name: 6-oxocineole dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+)." [EC:1.14.13.51, RHEA:24324] +synonym: "6-oxocineole oxygenase activity" RELATED [EC:1.14.13.51] +synonym: "6-oxocineole,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.13.51] +xref: EC:1.14.13.51 +xref: KEGG_REACTION:R02995 +xref: MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN +xref: RHEA:24324 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047598 +name: 7-dehydrocholesterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+." [EC:1.3.1.21] +synonym: "7-DHC reductase activity" RELATED [EC:1.3.1.21] +synonym: "cholesterol:NADP+ delta7-oxidoreductase activity" RELATED [EC:1.3.1.21] +synonym: "sterol Delta(7)-reductase activity" BROAD [EC:1.3.1.21] +synonym: "sterol delta7-reductase activity" RELATED [EC:1.3.1.21] +xref: EC:1.3.1.21 +xref: MetaCyc:RXN66-323 +xref: Reactome:R-HSA-196402 "Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol" +xref: Reactome:R-HSA-6807055 "DHCR7 reduces 7-dehydroCHOL to CHOL" +xref: RHEA:23984 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047599 +name: 8-oxocoformycin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH." [EC:1.1.1.235, RHEA:23168] +synonym: "8-ketodeoxycoformycin reductase activity" RELATED [EC:1.1.1.235] +synonym: "coformycin:NADP+ 8-oxidoreductase activity" RELATED [EC:1.1.1.235] +xref: EC:1.1.1.235 +xref: KEGG_REACTION:R03667 +xref: MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN +xref: RHEA:23168 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047600 +name: abequosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid." [EC:2.4.1.60, MetaCyc:ABEQUOSYLTRANSFERASE-RXN] +synonym: "CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity" RELATED [EC:2.4.1.60] +synonym: "trihexose diphospholipid abequosyltransferase activity" RELATED [EC:2.4.1.60] +xref: EC:2.4.1.60 +xref: MetaCyc:ABEQUOSYLTRANSFERASE-RXN +xref: RHEA:34183 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047601 +name: acetate kinase (diphosphate) activity +namespace: molecular_function +def: "Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." [EC:2.7.2.12, RHEA:24276] +synonym: "acetate kinase (pyrophosphate) activity" RELATED [EC:2.7.2.12] +synonym: "diphosphate:acetate phosphotransferase activity" RELATED [EC:2.7.2.12] +synonym: "pyrophosphate-acetate phosphotransferase activity" RELATED [EC:2.7.2.12] +xref: EC:2.7.2.12 +xref: KEGG_REACTION:R00320 +xref: MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN +xref: RHEA:24276 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047602 +name: acetoacetate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2)." [EC:4.1.1.4, RHEA:19729] +synonym: "acetoacetate carboxy-lyase (acetone-forming)" RELATED [EC:4.1.1.4] +synonym: "acetoacetate carboxy-lyase activity" RELATED [EC:4.1.1.4] +synonym: "acetoacetic acid decarboxylase activity" RELATED [EC:4.1.1.4] +xref: EC:4.1.1.4 +xref: KEGG_REACTION:R01366 +xref: MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN +xref: RHEA:19729 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047603 +name: acetoacetyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+)." [EC:3.1.2.11, RHEA:15673] +synonym: "acetoacetyl CoA deacylase activity" RELATED [EC:3.1.2.11] +synonym: "acetoacetyl coenzyme A deacylase activity" RELATED [EC:3.1.2.11] +synonym: "acetoacetyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.11] +xref: EC:3.1.2.11 +xref: KEGG_REACTION:R01358 +xref: MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN +xref: RHEA:15673 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047604 +name: acetoin racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-acetoin = (R)-acetoin." [EC:5.1.2.4, RHEA:12092] +synonym: "acetylmethylcarbinol racemase activity" RELATED [EC:5.1.2.4] +xref: EC:5.1.2.4 +xref: KEGG_REACTION:R02949 +xref: MetaCyc:ACETOIN-RACEMASE-RXN +xref: RHEA:12092 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0047605 +name: acetolactate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2." [EC:4.1.1.5, MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN] +synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]" RELATED [EC:4.1.1.5] +synonym: "(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity" RELATED [EC:4.1.1.5] +synonym: "alpha-acetolactate decarboxylase activity" RELATED [EC:4.1.1.5] +xref: EC:4.1.1.5 +xref: MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN +xref: RHEA:21580 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047606 +name: hydroxynitrilase activity +namespace: molecular_function +alt_id: GO:0046991 +def: "Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone." [GOC:mah, PMID:3377504] +synonym: "(S)-acetone-cyanohydrin lyase activity" NARROW [] +synonym: "2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)" NARROW [] +synonym: "2-hydroxyisobutyronitrile acetone-lyase activity" NARROW [] +synonym: "acetone-cyanhydrin lyase activity" NARROW [] +synonym: "acetone-cyanohydrin acetone-lyase (cyanide-forming)" NARROW [] +synonym: "acetone-cyanohydrin acetone-lyase activity" NARROW [] +synonym: "acetone-cyanohydrin lyase activity" NARROW [] +synonym: "alpha-hydroxynitrile lyase activity" NARROW [] +synonym: "hydroxynitrile lyase activity" EXACT [] +synonym: "oxynitrilase activity" RELATED [] +xref: EC:4.1.2.47 +xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047608 +name: acetylindoxyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown." [EC:1.7.3.2, MetaCyc:ACETYLINDOXYL-OXIDASE-RXN] +synonym: "N-acetylindoxyl:oxygen oxidoreductase activity" RELATED [EC:1.7.3.2] +xref: EC:1.7.3.2 +xref: MetaCyc:ACETYLINDOXYL-OXIDASE-RXN +xref: RHEA:16941 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047609 +name: acetylputrescine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine." [EC:3.5.1.62, RHEA:23412] +synonym: "N-acetylputrescine acetylhydrolase activity" RELATED [EC:3.5.1.62] +xref: EC:3.5.1.62 +xref: KEGG_REACTION:R01156 +xref: MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN +xref: RHEA:23412 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047610 +name: acetylsalicylate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate." [EC:3.1.1.55, RHEA:11752] +synonym: "acetylsalicylate O-acetylhydrolase activity" RELATED [EC:3.1.1.55] +synonym: "acetylsalicylic acid esterase activity" RELATED [EC:3.1.1.55] +synonym: "aspirin esterase activity" RELATED [EC:3.1.1.55] +synonym: "aspirin hydrolase activity" RELATED [EC:3.1.1.55] +xref: EC:3.1.1.55 +xref: KEGG_REACTION:R02942 +xref: MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN +xref: RHEA:11752 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047611 +name: acetylspermidine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine." [EC:3.5.1.48, RHEA:23928] +synonym: "8-N-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N(1)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N(8)-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N(8)-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +synonym: "N(8)-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +synonym: "N-acetylspermidine deacetylase activity" BROAD [EC:3.5.1.48] +synonym: "N1-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N8-acetylspermidine amidohydrolase activity" RELATED [EC:3.5.1.48] +synonym: "N8-acetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +synonym: "N8-monoacetylspermidine deacetylase activity" RELATED [EC:3.5.1.48] +xref: EC:3.5.1.48 +xref: KEGG_REACTION:R07300 +xref: MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN +xref: RHEA:23928 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0047612 +name: acid-CoA ligase (GDP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate." [RHEA:10968] +synonym: "acid:CoA ligase (GDP-forming)" RELATED [EC:6.2.1.10] +synonym: "acyl coenzyme A synthetase (guanosine diphosphate forming)" RELATED [EC:6.2.1.10] +synonym: "acyl-CoA synthetase (GDP-forming) activity" RELATED [EC:6.2.1.10] +xref: EC:6.2.1.10 +xref: KEGG_REACTION:R00394 +xref: MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN +xref: RHEA:10968 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047613 +name: aconitate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate." [EC:4.1.1.6, RHEA:15253] +synonym: "CAD activity" BROAD [EC:4.1.1.6] +synonym: "cis-aconitate carboxy-lyase (itaconate-forming)" RELATED [EC:4.1.1.6] +synonym: "cis-aconitate carboxy-lyase activity" RELATED [EC:4.1.1.6] +synonym: "cis-aconitic decarboxylase activity" RELATED [EC:4.1.1.6] +xref: EC:4.1.1.6 +xref: KEGG_REACTION:R02243 +xref: MetaCyc:ACONITATE-DECARBOXYLASE-RXN +xref: RHEA:15253 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047614 +name: aconitate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-aconitate = cis-aconitate." [EC:5.3.3.7, RHEA:17265] +synonym: "aconitate D-isomerase activity" EXACT [] +synonym: "aconitate delta2-delta3-isomerase activity" RELATED [EC:5.3.3.7] +synonym: "aconitate isomerase activity" BROAD [EC:5.3.3.7] +xref: EC:5.3.3.7 +xref: KEGG_REACTION:R02244 +xref: MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN +xref: RHEA:17265 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0047615 +name: actinomycin lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone." [EC:3.1.1.39, MetaCyc:ACTINOMYCIN-LACTONASE-RXN] +synonym: "actinomycin lactonohydrolase activity" RELATED [EC:3.1.1.39] +xref: EC:3.1.1.39 +xref: MetaCyc:ACTINOMYCIN-LACTONASE-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047616 +name: acyl-CoA dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.8, MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN] +synonym: "2-enoyl-CoA reductase activity" RELATED [EC:1.3.1.8] +synonym: "acyl-CoA:NADP+ 2-oxidoreductase activity" RELATED [EC:1.3.1.8] +synonym: "crotonyl coenzyme A reductase activity" RELATED [EC:1.3.1.8] +synonym: "dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.3.1.8] +synonym: "enoyl coenzyme A reductase activity" RELATED [EC:1.3.1.8] +xref: EC:1.3.1.8 +xref: MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN +xref: RHEA:22460 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047617 +name: acyl-CoA hydrolase activity +namespace: molecular_function +alt_id: GO:0008778 +alt_id: GO:0016291 +alt_id: GO:0016292 +def: "Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate." [RHEA:16781] +synonym: "acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.20] +synonym: "acyl coenzyme A thioesterase activity" RELATED [EC:3.1.2.20] +synonym: "acyl-CoA thioesterase activity" EXACT [] +synonym: "acyl-CoA thioesterase I activity" NARROW [] +synonym: "acyl-CoA thioesterase II activity" NARROW [] +synonym: "acyl-CoA thiolesterase activity" EXACT [] +synonym: "thioesterase B" RELATED [EC:3.1.2.20] +synonym: "thioesterase II" RELATED [EC:3.1.2.20] +xref: EC:3.1.2.20 +xref: MetaCyc:ACYL-COA-HYDROLASE-RXN +xref: Reactome:R-HSA-5690042 "Peroxisomal ACOT4,6,8 hydrolyse MCFA-CoA, LCFA-CoA" +xref: Reactome:R-HSA-5690043 "Cytosolic ACOTs hydrolyse MCFA-CoA, LCFA-CoA" +xref: Reactome:R-HSA-5690066 "ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA" +xref: RHEA:16781 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047618 +name: acylagmatine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate." [EC:3.5.1.40, RHEA:15065] +synonym: "acylagmatine amidohydrolase activity" RELATED [EC:3.5.1.40] +synonym: "acylagmatine deacylase activity" RELATED [EC:3.5.1.40] +synonym: "benzoylagmatine amidohydrolase activity" RELATED [EC:3.5.1.40] +xref: EC:3.5.1.40 +xref: KEGG_REACTION:R01425 +xref: MetaCyc:ACYLAGMATINE-AMIDASE-RXN +xref: RHEA:15065 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047619 +name: acylcarnitine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine." [EC:3.1.1.28, MetaCyc:ACYLCARNITINE-HYDROLASE-RXN] +synonym: "carnitine ester hydrolase activity" RELATED [EC:3.1.1.28] +synonym: "HACH" RELATED [EC:3.1.1.28] +synonym: "high activity acylcarnitine hydrolase activity" RELATED [EC:3.1.1.28] +synonym: "long-chain acyl-L-carnitine hydrolase activity" RELATED [EC:3.1.1.28] +synonym: "O-acylcarnitine acylhydrolase activity" RELATED [EC:3.1.1.28] +synonym: "palmitoyl carnitine hydrolase activity" RELATED [EC:3.1.1.28] +synonym: "palmitoyl-L-carnitine hydrolase activity" RELATED [EC:3.1.1.28] +synonym: "palmitoylcarnitine hydrolase activity" RELATED [EC:3.1.1.28] +xref: EC:3.1.1.28 +xref: MetaCyc:ACYLCARNITINE-HYDROLASE-RXN +xref: RHEA:17101 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047620 +name: acylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate." [EC:2.7.1.94, MetaCyc:ACYLGLYCEROL-KINASE-RXN] +synonym: "ATP:acylglycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.94] +synonym: "MGK" RELATED [EC:2.7.1.94] +synonym: "monoacylglycerol kinase (phosphorylating)" RELATED [EC:2.7.1.94] +synonym: "monoacylglycerol kinase activity" RELATED [EC:2.7.1.94] +synonym: "monoglyceride kinase activity" RELATED [EC:2.7.1.94] +synonym: "monoglyceride phosphokinase activity" RELATED [EC:2.7.1.94] +synonym: "sn-2-monoacylglycerol kinase activity" RELATED [EC:2.7.1.94] +xref: EC:2.7.1.94 +xref: MetaCyc:ACYLGLYCEROL-KINASE-RXN +xref: Reactome:R-HSA-5696074 "AGK:Mg2+ phosphorylates MAG, DAG" +xref: RHEA:19293 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047621 +name: acylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate." [EC:3.7.1.5, MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN] +synonym: "3-acylpyruvate acylhydrolase activity" RELATED [EC:3.7.1.5] +xref: EC:3.7.1.5 +xref: MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN +xref: RHEA:19009 +xref: UM-BBD_reactionID:r1401 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047622 +name: adenosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine + H2O = D-ribose + adenine." [EC:3.2.2.7, MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN] +synonym: "adenosinase activity" RELATED [EC:3.2.2.7] +synonym: "adenosine hydrolase activity" RELATED [EC:3.2.2.7] +synonym: "adenosine ribohydrolase activity" RELATED [EC:3.2.2.7] +synonym: "ANase activity" RELATED [EC:3.2.2.7] +synonym: "N-ribosyladenine ribohydrolase activity" RELATED [EC:3.2.2.7] +xref: EC:3.2.2.7 +xref: MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN +xref: RHEA:18669 +is_a: GO:0008477 ! purine nucleosidase activity + +[Term] +id: GO:0047623 +name: adenosine-phosphate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP." [EC:3.5.4.17, GOC:bf, MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN] +comment: Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692. +synonym: "adenine nucleotide deaminase activity" RELATED [EC:3.5.4.17] +synonym: "adenosine (phosphate) deaminase activity" RELATED [EC:3.5.4.17] +synonym: "adenosine-phosphate aminohydrolase activity" RELATED [EC:3.5.4.17] +xref: EC:3.5.4.17 +xref: MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047624 +name: adenosine-tetraphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate." [EC:3.6.1.14, MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN] +synonym: "adenosine-tetraphosphate phosphohydrolase activity" RELATED [EC:3.6.1.14] +xref: EC:3.6.1.14 +xref: MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN +xref: RHEA:24500 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047625 +name: adenosylmethionine cyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone." [EC:2.5.1.4, RHEA:21932] +synonym: "adenosyl methionine cyclotransferase activity" EXACT [] +synonym: "adenosylmethioninase activity" RELATED [EC:2.5.1.4] +synonym: "S-adenosyl-L-methionine alkyltransferase (cyclizing)" RELATED [EC:2.5.1.4] +xref: EC:2.5.1.4 +xref: KEGG_REACTION:R00180 +xref: MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN +xref: RHEA:21932 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047626 +name: adenosylmethionine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+)." [EC:3.3.1.2, RHEA:14645] +synonym: "adenosyl methionine hydrolase activity" EXACT [] +synonym: "adenosylmethionine lyase activity" RELATED [EC:3.3.1.2] +synonym: "methylmethionine-sulfonium-salt hydrolase activity" RELATED [EC:3.3.1.2] +synonym: "S-adenosyl-L-methionine hydrolase activity" RELATED [EC:3.3.1.2] +synonym: "S-adenosylmethionine cleaving enzyme activity" RELATED [EC:3.3.1.2] +xref: EC:3.3.1.2 +xref: KEGG_REACTION:R00175 +xref: MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN +xref: RHEA:14645 +is_a: GO:0016802 ! trialkylsulfonium hydrolase activity + +[Term] +id: GO:0047627 +name: adenylylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate." [EC:3.6.2.1, RHEA:17041] +synonym: "adenosine 5-phosphosulfate sulfohydrolase activity" RELATED [EC:3.6.2.1] +synonym: "adenylylsulfate sulfohydrolase activity" RELATED [EC:3.6.2.1] +synonym: "adenylylsulphatase activity" EXACT [] +xref: EC:3.6.2.1 +xref: KEGG_REACTION:R00531 +xref: MetaCyc:ADENYLYLSULFATASE-RXN +xref: RHEA:17041 +is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides + +[Term] +id: GO:0047628 +name: ADP-thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate." [EC:2.7.1.118, MetaCyc:ADP--THYMIDINE-KINASE-RXN] +synonym: "adenosine diphosphate-thymidine phosphotransferase activity" RELATED [EC:2.7.1.118] +synonym: "ADP:dThd phosphotransferase activity" RELATED [EC:2.7.1.118] +synonym: "ADP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.118] +xref: EC:2.7.1.118 +xref: MetaCyc:ADP--THYMIDINE-KINASE-RXN +xref: RHEA:13413 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047629 +name: ADP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP + H2O = IDP + NH3." [EC:3.5.4.7, MetaCyc:ADP-DEAMINASE-RXN] +synonym: "adenosine diphosphate deaminase activity" RELATED [EC:3.5.4.7] +synonym: "adenosinepyrophosphate deaminase activity" RELATED [EC:3.5.4.7] +synonym: "ADP aminohydrolase activity" RELATED [EC:3.5.4.7] +xref: EC:3.5.4.7 +xref: MetaCyc:ADP-DEAMINASE-RXN +xref: RHEA:12741 +is_a: GO:0047623 ! adenosine-phosphate deaminase activity + +[Term] +id: GO:0047630 +name: ADP-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate." [EC:3.1.3.28, RHEA:15861] +synonym: "3-(ADP)-2-phosphoglycerate phosphohydrolase activity" RELATED [EC:3.1.3.28] +synonym: "adenosine diphosphate phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.28] +synonym: "ADPphosphoglycerate phosphatase activity" RELATED [EC:3.1.3.28] +xref: EC:3.1.3.28 +xref: KEGG_REACTION:R03969 +xref: MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN +xref: RHEA:15861 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047631 +name: ADP-ribose diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate." [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN] +synonym: "adenosine diphosphoribose pyrophosphatase activity" EXACT [] +synonym: "ADP-ribose phosphohydrolase activity" EXACT [] +synonym: "ADP-ribose pyrophosphatase activity" EXACT [] +synonym: "ADP-ribose ribophosphohydrolase activity" RELATED [EC:3.6.1.13] +synonym: "ADPR-PPase activity" EXACT [] +synonym: "ADPribose diphosphatase activity" RELATED [EC:3.6.1.13] +synonym: "ADPribose pyrophosphatase activity" RELATED [EC:3.6.1.13] +xref: EC:3.6.1.13 +xref: MetaCyc:RXN0-1441 +xref: Reactome:R-HSA-2393939 "Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP" +xref: Reactome:R-HSA-2393954 "Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP" +xref: Reactome:R-HSA-5696049 "ADPRM hydrolyses ADP-ribose to R5P and AMP" +xref: RHEA:10412 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047632 +name: agmatine deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3." [EC:3.5.3.12, MetaCyc:AGMATINE-DEIMINASE-RXN] +synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.12] +synonym: "agmatine iminohydrolase activity" RELATED [EC:3.5.3.12] +xref: EC:3.5.3.12 +xref: MetaCyc:AGMATINE-DEIMINASE-RXN +xref: RHEA:18037 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047633 +name: agmatine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+)." [EC:2.7.3.10, RHEA:15953] +synonym: "ATP:agmatine 4-N-phosphotransferase activity" RELATED [EC:2.7.3.10] +synonym: "ATP:agmatine N4-phosphotransferase activity" RELATED [EC:2.7.3.10] +synonym: "phosphagen phosphokinase activity" RELATED [EC:2.7.3.10] +xref: EC:2.7.3.10 +xref: KEGG_REACTION:R01417 +xref: MetaCyc:AGMATINE-KINASE-RXN +xref: RHEA:15953 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047634 +name: agmatine N4-coumaroyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+)." [EC:2.3.1.64, RHEA:13405] +synonym: "4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity" RELATED [EC:2.3.1.64] +synonym: "4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity" RELATED [EC:2.3.1.64] +synonym: "agmatine coumaroyltransferase activity" RELATED [EC:2.3.1.64] +synonym: "p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity" RELATED [EC:2.3.1.64] +xref: EC:2.3.1.64 +xref: KEGG_REACTION:R01617 +xref: MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN +xref: RHEA:13405 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047635 +name: alanine-oxo-acid transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid." [EC:2.6.1.12, MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN] +synonym: "alanine--oxo-acid aminotransferase activity" RELATED [EC:2.6.1.12] +synonym: "alanine-keto acid aminotransferase activity" RELATED [EC:2.6.1.12] +synonym: "alanine-oxo acid aminotransferase activity" RELATED [EC:2.6.1.12] +synonym: "alanine-oxo-acid aminotransferase activity" EXACT [] +synonym: "L-alanine-alpha-keto acid aminotransferase activity" RELATED [EC:2.6.1.12] +synonym: "L-alanine:2-oxo-acid aminotransferase activity" RELATED [EC:2.6.1.12] +synonym: "leucine-alanine transaminase activity" RELATED [EC:2.6.1.12] +xref: EC:2.6.1.12 +xref: MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN +xref: RHEA:19953 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047636 +name: alanopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.17, RHEA:17589] +synonym: "2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)" RELATED [EC:1.5.1.17] +synonym: "ADH" RELATED [EC:1.5.1.17] +synonym: "alanopine: NAD oxidoreductase activity" RELATED [EC:1.5.1.17] +synonym: "alanopine:NAD oxidoreductase activity" RELATED [EC:1.5.1.17] +synonym: "alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity" RELATED [EC:1.5.1.17] +synonym: "ALPDH" RELATED [EC:1.5.1.17] +synonym: "meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.17] +xref: EC:1.5.1.17 +xref: KEGG_REACTION:R00398 +xref: MetaCyc:ALANOPINE-DEHYDROGENASE-RXN +xref: RHEA:17589 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047637 +name: alanylphosphatidylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol." [EC:2.3.2.11, MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN] +synonym: "alanyl phosphatidylglycerol synthetase activity" RELATED [EC:2.3.2.11] +synonym: "L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity" RELATED [EC:2.3.2.11] +synonym: "O-alanylphosphatidylglycerol synthase activity" RELATED [EC:2.3.2.11] +xref: EC:2.3.2.11 +xref: MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN +xref: RHEA:20489 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0047638 +name: albendazole monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+)." [EC:1.14.13.32, RHEA:10796] +synonym: "albendazole oxidase activity" RELATED [EC:1.14.13.32] +synonym: "albendazole sulfoxidase activity" RELATED [EC:1.14.13.32] +synonym: "albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)" RELATED [EC:1.14.13.32] +xref: EC:1.14.13.32 +xref: KEGG_REACTION:R03712 +xref: MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN +xref: RHEA:10796 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047639 +name: alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2." [EC:1.1.3.13, MetaCyc:ALCOHOL-OXIDASE-RXN] +comment: Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). +synonym: "alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.13] +synonym: "AOX activity" RELATED [EC:1.1.3.13] +synonym: "ethanol oxidase activity" RELATED [EC:1.1.3.13] +xref: EC:1.1.3.13 +xref: MetaCyc:ALCOHOL-OXIDASE-RXN +xref: RHEA:19829 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047640 +name: aldose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH." [EC:1.1.1.121, MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN] +synonym: "aldose dehydrogenase activity" RELATED [EC:1.1.1.121] +synonym: "D-aldose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.121] +synonym: "dehydrogenase, D-aldohexose" RELATED [EC:1.1.1.121] +xref: EC:1.1.1.121 +xref: MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN +xref: RHEA:15917 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047641 +name: aldose-6-phosphate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH." [EC:1.1.1.200, RHEA:20037] +synonym: "A6PR" RELATED [EC:1.1.1.200] +synonym: "alditol 6-phosphate:NADP 1-oxidoreductase activity" RELATED [EC:1.1.1.200] +synonym: "aldose 6-phosphate reductase activity" RELATED [EC:1.1.1.200] +synonym: "aldose-6-P reductase activity" RELATED [EC:1.1.1.200] +synonym: "aldose-6-phosphate reductase activity" RELATED [EC:1.1.1.200] +synonym: "D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.200] +synonym: "NADP-dependent aldose 6-phosphate reductase activity" RELATED [EC:1.1.1.200] +synonym: "NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity" RELATED [EC:1.1.1.200] +xref: EC:1.1.1.200 +xref: KEGG_REACTION:R00834 +xref: MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN +xref: RHEA:20037 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047642 +name: aldose beta-D-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside." [EC:2.4.1.162, MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN] +synonym: "aldose b-D-fructosyltransferase activity" EXACT [] +synonym: "alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.162] +xref: EC:2.4.1.162 +xref: MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0047643 +name: alginate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1)." [EC:2.4.1.33, MetaCyc:ALGINATE-SYNTHASE-RXN] +synonym: "GDP-D-mannuronate:alginate D-mannuronyltransferase activity" RELATED [EC:2.4.1.33] +synonym: "mannuronosyl transferase activity" RELATED [EC:2.4.1.33] +xref: EC:2.4.1.33 +xref: MetaCyc:ALGINATE-SYNTHASE-RXN +xref: RHEA:46876 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047644 +name: alizarin 2-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP." [EC:2.4.1.103, RHEA:20677] +synonym: "alizarin 2-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.103] +synonym: "UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity" RELATED [EC:2.4.1.103] +synonym: "uridine diphosphoglucose-alizarin glucosyltransferase activity" RELATED [EC:2.4.1.103] +xref: EC:2.4.1.103 +xref: KEGG_REACTION:R03573 +xref: MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:20677 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047645 +name: alkan-1-ol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor." [EC:1.1.99.20, MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN] +synonym: "alkan-1-ol:(acceptor) oxidoreductase activity" RELATED [EC:1.1.99.20] +synonym: "alkan-1-ol:acceptor oxidoreductase activity" RELATED [EC:1.1.99.20] +synonym: "polyethylene glycol dehydrogenase activity" NARROW [EC:1.1.99.20] +xref: EC:1.1.99.20 +xref: MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN +xref: RHEA:14685 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047646 +name: alkanal monooxygenase (FMN-linked) activity +namespace: molecular_function +def: "Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light." [EC:1.14.14.3, MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN] +synonym: "aldehyde monooxygenase activity" BROAD [EC:1.14.14.3] +synonym: "alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing)" RELATED [EC:1.14.14.3] +synonym: "bacterial luciferase activity" RELATED [EC:1.14.14.3] +synonym: "vibrio fischeri luciferase activity" RELATED [EC:1.14.14.3] +xref: EC:1.14.14.3 +xref: MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN +xref: RHEA:17181 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047647 +name: alkylacetylglycerophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate." [EC:3.1.3.59, RHEA:18221] +synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.59] +synonym: "1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity" RELATED [EC:3.1.3.59] +synonym: "alkylacetylglycerophosphate phosphatase activity" RELATED [EC:3.1.3.59] +xref: EC:3.1.3.59 +xref: KEGG_REACTION:R03454 +xref: MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN +xref: RHEA:18221 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047648 +name: alkylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium." [EC:3.5.1.39, RHEA:20081] +synonym: "N-methylhexanamide amidohydrolase activity" RELATED [EC:3.5.1.39] +xref: EC:3.5.1.39 +xref: KEGG_REACTION:R03620 +xref: MetaCyc:ALKYLAMIDASE-RXN +xref: RHEA:20081 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047649 +name: alkylglycerol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.93, RHEA:16937] +synonym: "1-alkylglycerol kinase (phosphorylating)" RELATED [EC:2.7.1.93] +synonym: "alkylglycerol phosphotransferase activity" RELATED [EC:2.7.1.93] +synonym: "ATP-alkylglycerol phosphotransferase activity" RELATED [EC:2.7.1.93] +synonym: "ATP:1-alkyl-sn-glycerol phosphotransferase activity" RELATED [EC:2.7.1.93] +synonym: "ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity" RELATED [EC:2.7.1.93] +xref: EC:2.7.1.93 +xref: KEGG_REACTION:R04126 +xref: MetaCyc:ALKYLGLYCEROL-KINASE-RXN +xref: RHEA:16937 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047650 +name: alkylglycerone kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+)." [EC:2.7.1.84, RHEA:23088] +synonym: "alkyldihydroxyacetone kinase (phosphorylating)" RELATED [EC:2.7.1.84] +synonym: "alkyldihydroxyacetone kinase activity" RELATED [EC:2.7.1.84] +synonym: "ATP:O-alkylglycerone phosphotransferase activity" RELATED [EC:2.7.1.84] +xref: EC:2.7.1.84 +xref: KEGG_REACTION:R03944 +xref: MetaCyc:ALKYLGLYCERONE-KINASE-RXN +xref: RHEA:23088 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047651 +name: alkylhalidase activity +namespace: molecular_function +def: "Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+)." [RHEA:13765] +synonym: "alkyl-halide halidohydrolase activity" RELATED [] +synonym: "haloalkane halidohydrolase activity" RELATED [] +synonym: "halogenase activity" RELATED [] +xref: KEGG_REACTION:R03523 +xref: MetaCyc:ALKYLHALIDASE-RXN +xref: RHEA:13765 +is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds + +[Term] +id: GO:0047652 +name: allantoate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine." [EC:3.5.3.9, MetaCyc:ALLANTOATE-DEIMINASE-RXN] +synonym: "allantoate amidinohydrolase (decarboxylating)" RELATED [EC:3.5.3.9] +synonym: "allantoate amidohydrolase activity" RELATED [EC:3.5.3.9] +xref: EC:3.5.3.9 +xref: MetaCyc:ALLANTOATE-DEIMINASE-RXN +xref: RHEA:27485 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047653 +name: allantoin racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin." [EC:5.1.99.3, RHEA:10804] +xref: EC:5.1.99.3 +xref: KEGG_REACTION:R03925 +xref: MetaCyc:ALLANTOIN-RACEMASE-RXN +xref: RHEA:10804 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0047654 +name: alliin lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate." [EC:4.4.1.4, MetaCyc:ALLIIN-LYASE-RXN] +synonym: "alkylcysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4] +synonym: "alliin alkyl-sulfenate-lyase activity" RELATED [EC:4.4.1.4] +synonym: "alliinase activity" RELATED [EC:4.4.1.4] +synonym: "cysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4] +synonym: "cysteine sulphoxide lyase activity" RELATED [EC:4.4.1.4] +synonym: "L-cysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4] +synonym: "S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)" RELATED [EC:4.4.1.4] +synonym: "S-alkylcysteine sulfoxide lyase activity" RELATED [EC:4.4.1.4] +xref: EC:4.4.1.4 +xref: MetaCyc:ALLIIN-LYASE-RXN +xref: RHEA:20141 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047655 +name: allyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH." [EC:1.1.1.54, RHEA:12168] +synonym: "allyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.54] +xref: EC:1.1.1.54 +xref: KEGG_REACTION:R03572 +xref: MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:12168 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047656 +name: alpha,alpha-trehalose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.64, MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN] +synonym: "a,a-trehalose phosphorylase activity" EXACT [] +synonym: "alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.64] +synonym: "trehalose phosphorylase" BROAD [EC:2.4.1.64] +xref: EC:2.4.1.64 +xref: MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN +xref: RHEA:23512 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0047657 +name: alpha-1,3-glucan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1." [EC:2.4.1.183, MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN] +synonym: "1,3-alpha-D-glucan synthase activity" RELATED [EC:2.4.1.183] +synonym: "1,3-alpha-glucan synthase activity" EXACT [] +synonym: "a-1,3-glucan synthase activity" EXACT [] +synonym: "UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.183] +synonym: "UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.183] +synonym: "uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.183] +xref: EC:2.4.1.183 +xref: MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN +xref: RHEA:19749 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047658 +name: alpha-amino-acid esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol." [EC:3.1.1.43, MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN] +synonym: "a-amino-acid esterase activity" EXACT [] +synonym: "alpha-amino acid ester hydrolase activity" RELATED [EC:3.1.1.43] +synonym: "alpha-amino-acid ester hydrolase activity" RELATED [EC:3.1.1.43] +synonym: "alpha-amino-acid-ester aminoacylhydrolase activity" RELATED [EC:3.1.1.43] +xref: EC:3.1.1.43 +xref: MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN +xref: Reactome:R-HSA-6784959 "BPHL hydrolyses VACV to ACV" +xref: RHEA:17241 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047659 +name: alpha-santonin 1,2-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+." [EC:1.3.1.47, MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN] +synonym: "1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity" RELATED [EC:1.3.1.47] +synonym: "a-santonin 1,2-reductase activity" EXACT [] +xref: EC:1.3.1.47 +xref: MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047660 +name: amidinoaspartase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea." [EC:3.5.3.14, RHEA:14849] +synonym: "amidinoaspartic amidinohydrolase activity" RELATED [EC:3.5.3.14] +synonym: "N-amidino-L-aspartate amidinohydrolase activity" RELATED [EC:3.5.3.14] +xref: EC:3.5.3.14 +xref: KEGG_REACTION:R00777 +xref: MetaCyc:AMIDINOASPARTASE-RXN +xref: RHEA:14849 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047661 +name: amino-acid racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-amino acid = a D-amino acid." [EC:5.1.1.10, MetaCyc:AMINO-ACID-RACEMASE-RXN] +synonym: "L-amino acid racemase activity" RELATED [EC:5.1.1.10] +xref: EC:5.1.1.10 +xref: MetaCyc:AMINO-ACID-RACEMASE-RXN +xref: RHEA:18317 +is_a: GO:0036361 ! racemase activity, acting on amino acids and derivatives + +[Term] +id: GO:0047662 +name: aminobenzoate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2." [EC:4.1.1.24, MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN] +synonym: "aminobenzoate carboxy-lyase (aniline-forming)" RELATED [EC:4.1.1.24] +synonym: "aminobenzoate carboxy-lyase activity" RELATED [EC:4.1.1.24] +xref: EC:4.1.1.24 +xref: MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN +xref: RHEA:24200 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047663 +name: aminoglycoside 6'-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.82, RHEA:16449] +synonym: "6'-aminoglycoside-N-acetyltransferase activity" RELATED [EC:2.3.1.82] +synonym: "AAC(6') activity" RELATED [EC:2.3.1.82] +synonym: "acetyl-CoA:kanamycin-B N6'-acetyltransferase activity" NARROW [EC:2.3.1.82] +synonym: "aminoglycoside N6'-acetyltransferase activity" EXACT [] +synonym: "aminoglycoside-6'-acetyltransferase activity" RELATED [EC:2.3.1.82] +synonym: "aminoglycoside-6-N-acetyltransferase activity" RELATED [EC:2.3.1.82] +synonym: "kanamycin 6'-N-acetyltransferase activity" NARROW [] +xref: EC:2.3.1.82 +xref: KEGG_REACTION:R01889 +xref: MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN +xref: RHEA:16449 +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0047664 +name: aminoimidazolase activity +namespace: molecular_function +def: "Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3)." [RHEA:22348] +synonym: "4-aminoimidazole aminohydrolase activity" RELATED [EC:3.5.4.8] +synonym: "4-aminoimidazole hydrolase activity" RELATED [EC:3.5.4.8] +xref: EC:3.5.4.8 +xref: MetaCyc:R13-RXN +xref: RHEA:22348 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0047665 +name: aminolevulinate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine." [EC:2.6.1.43, RHEA:12480] +synonym: "4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "4,5-dioxovaleric acid aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "4,5-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43] +synonym: "4,5-dioxovaleric transaminase activity" RELATED [EC:2.6.1.43] +synonym: "5-aminolevulinate:pyruvate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "5-aminolevulinic acid transaminase activity" RELATED [EC:2.6.1.43] +synonym: "alanine-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "alanine-gamma,delta-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "alanine:4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "aminolevulinate aminotransferase activity" EXACT [] +synonym: "aminolevulinic acid transaminase activity" RELATED [EC:2.6.1.43] +synonym: "dioxovalerate transaminase activity" RELATED [EC:2.6.1.43] +synonym: "DOVA transaminase activity" RELATED [EC:2.6.1.43] +synonym: "gamma,delta-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "gamma,delta-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43] +synonym: "L-alanine-4,5-dioxovalerate aminotransferase activity" RELATED [EC:2.6.1.43] +synonym: "L-alanine:4,5-dioxovaleric acid transaminase activity" RELATED [EC:2.6.1.43] +synonym: "L-alanine:dioxovalerate transaminase activity" RELATED [EC:2.6.1.43] +xref: EC:2.6.1.43 +xref: KEGG_REACTION:R02271 +xref: MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN +xref: RHEA:12480 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047666 +name: ammonia kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate." [EC:2.7.3.8, RHEA:11024] +synonym: "ATP:ammonia phosphotransferase activity" RELATED [EC:2.7.3.8] +synonym: "phosphoramidate-adenosine diphosphate phosphotransferase activity" RELATED [EC:2.7.3.8] +synonym: "phosphoramidate-ADP-phosphotransferase activity" RELATED [EC:2.7.3.8] +xref: EC:2.7.3.8 +xref: KEGG_REACTION:R00141 +xref: MetaCyc:AMMONIA-KINASE-RXN +xref: RHEA:11024 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047667 +name: AMP-thymidine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate." [EC:2.7.1.114, MetaCyc:AMP--THYMIDINE-KINASE-RXN] +synonym: "adenylate-nucleoside phosphotransferase activity" RELATED [EC:2.7.1.114] +synonym: "adenylic acid:deoxythymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114] +synonym: "AMP:deoxythymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114] +synonym: "AMP:deoxythymidine kinase activity" RELATED [EC:2.7.1.114] +synonym: "AMP:dThd kinase activity" RELATED [EC:2.7.1.114] +synonym: "AMP:thymidine 5'-phosphotransferase activity" RELATED [EC:2.7.1.114] +synonym: "thymidine phosphotransferase activity" RELATED [EC:2.7.1.114] +xref: EC:2.7.1.114 +xref: MetaCyc:AMP--THYMIDINE-KINASE-RXN +xref: RHEA:14913 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047668 +name: amygdalin beta-glucosidase activity +namespace: molecular_function +alt_id: GO:0080080 +def: "Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose." [EC:3.2.1.117, RHEA:14177] +synonym: "(R)-amygdalin beta-glucosidase activity" EXACT [] +synonym: "amygdalin b-glucosidase activity" EXACT [] +synonym: "amygdalin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.117] +synonym: "amygdalin glucosidase activity" RELATED [EC:3.2.1.117] +synonym: "amygdalin hydrolase activity" RELATED [EC:3.2.1.117] +synonym: "amygdalinase" BROAD [EC:3.2.1.117] +xref: EC:3.2.1.117 +xref: KEGG_REACTION:R02985 +xref: MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN +xref: RHEA:14177 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0047669 +name: amylosucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1)." [EC:2.4.1.4, MetaCyc:AMYLOSUCRASE-RXN] +synonym: "sucrose-1,4-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.4] +synonym: "sucrose-glucan glucosyltransferase activity" RELATED [EC:2.4.1.4] +synonym: "sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.4] +xref: EC:2.4.1.4 +xref: MetaCyc:AMYLOSUCRASE-RXN +xref: RHEA:24572 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047670 +name: anhydrotetracycline monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+)." [EC:1.14.13.38, RHEA:11976] +synonym: "anhydrotetracycline oxygenase activity" RELATED [EC:1.14.13.38] +synonym: "anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)" RELATED [EC:1.14.13.38] +synonym: "ATC oxygenase activity" RELATED [EC:1.14.13.38] +xref: EC:1.14.13.38 +xref: KEGG_REACTION:R04060 +xref: MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN +xref: RHEA:11976 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047671 +name: anthranilate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+)." [PMID:2995633, RHEA:35091] +synonym: "anthranilic acid adenylyltransferase activity" RELATED [EC:2.7.7.55] +synonym: "ATP:anthranilate adenylyltransferase activity" EXACT [] +synonym: "ATP:anthranilate N-adenylyltransferase activity" RELATED [EC:2.7.7.55] +xref: EC:6.3.2.40 +xref: KEGG_REACTION:R00979 +xref: MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN +xref: RHEA:35091 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0047672 +name: anthranilate N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA." [EC:2.3.1.144, RHEA:21600] +synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.3.1.144] +xref: EC:2.3.1.144 +xref: KEGG_REACTION:R02453 +xref: MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN +xref: RHEA:21600 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047673 +name: anthranilate N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA." [EC:2.3.1.113, RHEA:17557] +synonym: "malonyl-CoA:anthranilate N-malonyltransferase activity" RELATED [EC:2.3.1.113] +xref: EC:2.3.1.113 +xref: KEGG_REACTION:R00989 +xref: MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN +xref: RHEA:17557 +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047674 +name: apiose 1-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH." [EC:1.1.1.114, RHEA:15301] +synonym: "D-apiitol reductase activity" RELATED [EC:1.1.1.114] +synonym: "D-apiitol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.114] +synonym: "D-apiose reductase activity" RELATED [EC:1.1.1.114] +xref: EC:1.1.1.114 +xref: KEGG_REACTION:R03577 +xref: MetaCyc:APIOSE-1-REDUCTASE-RXN +xref: RHEA:15301 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047675 +name: arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.5, RHEA:21836] +synonym: "D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming)" RELATED [EC:4.2.1.5] +synonym: "D-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.5] +xref: EC:4.2.1.5 +xref: KEGG_REACTION:R03032 +xref: MetaCyc:ARABINONATE-DEHYDRATASE-RXN +xref: RHEA:21836 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047676 +name: arachidonate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+)." [RHEA:19713] +synonym: "arachidonate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.15] +synonym: "arachidonoyl-CoA synthetase activity" RELATED [EC:6.2.1.15] +xref: EC:6.2.1.15 +xref: KEGG_REACTION:R01598 +xref: MetaCyc:ARACHIDONATE--COA-LIGASE-RXN +xref: RHEA:19713 +is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0047677 +name: arachidonate 8(R)-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.40, RHEA:14985] +comment: This activity produces the R-enantiomer of HPETE, 8(R)-HPETE. For the reaction producing the S-enantiomer, see GO:0036403. +synonym: "8(R)-lipoxygenase activity" RELATED [EC:1.13.11.40] +synonym: "8-lipoxygenase activity" NARROW [EC:1.13.11.40] +synonym: "arachidonate 8-lipoxygenase activity" BROAD [GOC:lb] +synonym: "arachidonate:oxygen 8-oxidoreductase activity" RELATED [EC:1.13.11.40] +xref: EC:1.13.11.40 +xref: KEGG_REACTION:R01594 +xref: MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN +xref: RHEA:14985 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047678 +name: arginine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O." [EC:1.13.12.1, RHEA:10548] +synonym: "arginine decarboxy-oxidase activity" RELATED [EC:1.13.12.1] +synonym: "arginine monooxygenase activity" RELATED [EC:1.13.12.1] +synonym: "arginine oxygenase (decarboxylating) activity" RELATED [EC:1.13.12.1] +synonym: "L-arginine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.1] +xref: EC:1.13.12.1 +xref: KEGG_REACTION:R00559 +xref: MetaCyc:ARGININE-2-MONOOXYGENASE-RXN +xref: RHEA:10548 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0047679 +name: arginine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine = D-arginine." [EC:5.1.1.9, MetaCyc:ARGININE-RACEMASE-RXN] +xref: EC:5.1.1.9 +xref: MetaCyc:ARGININE-RACEMASE-RXN +xref: RHEA:18069 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0047680 +name: aryl-acylamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+)." [EC:3.5.1.13, RHEA:20297] +synonym: "AAA-1" RELATED [EC:3.5.1.13] +synonym: "AAA-2" RELATED [EC:3.5.1.13] +synonym: "aryl-acylamide amidohydrolase activity" RELATED [EC:3.5.1.13] +synonym: "brain acetylcholinesterase (is associated with AAA-2)" RELATED [EC:3.5.1.13] +synonym: "pseudocholinesterase (associated with arylacylamidase)" RELATED [EC:3.5.1.13] +xref: EC:3.5.1.13 +xref: KEGG_REACTION:R01862 +xref: MetaCyc:ARYL-ACYLAMIDASE-RXN +xref: RHEA:20297 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047681 +name: aryl-alcohol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH." [EC:1.1.1.91, MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN] +synonym: "aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)" RELATED [EC:1.1.1.91] +synonym: "aryl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.91] +synonym: "NADPH-linked benzaldehyde reductase activity" RELATED [EC:1.1.1.91] +xref: EC:1.1.1.91 +xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:17761 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047682 +name: aryl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2." [EC:1.1.3.7, MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN] +synonym: "arom. alcohol oxidase activity" RELATED [EC:1.1.3.7] +synonym: "aryl alcohol oxidase activity" RELATED [EC:1.1.3.7] +synonym: "aryl-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.7] +synonym: "veratryl alcohol oxidase activity" NARROW [EC:1.1.3.7] +xref: EC:1.1.3.7 +xref: MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN +xref: RHEA:17541 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047683 +name: aryl-aldehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP." [EC:1.2.1.30, MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN] +synonym: "aromatic acid reductase activity" RELATED [EC:1.2.1.30] +synonym: "aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)" RELATED [EC:1.2.1.30] +xref: EC:1.2.1.30 +xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:19229 +is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity + +[Term] +id: GO:0047684 +name: arylamine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine." [EC:2.4.1.71, MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP glucose-arylamine glucosyltransferase activity" RELATED [EC:2.4.1.71] +synonym: "UDP-glucose:arylamine N-D-glucosyltransferase activity" RELATED [EC:2.4.1.71] +synonym: "UDPglucose:arylamine N-D-glucosyltransferase activity" RELATED [EC:2.4.1.71] +synonym: "uridine diphosphoglucose-arylamine glucosyltransferase activity" RELATED [EC:2.4.1.71] +xref: EC:2.4.1.71 +xref: MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047685 +name: amine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate." [EC:2.8.2.3, MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity" RELATED [EC:2.8.2.3] +synonym: "amine N-sulfotransferase activity" RELATED [EC:2.8.2.3] +synonym: "amine sulphotransferase activity" EXACT [] +synonym: "arylamine sulfotransferase activity" EXACT [] +xref: EC:2.8.2.3 +xref: MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN +xref: RHEA:24136 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047686 +name: arylsulfate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate." [EC:2.8.2.22, MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN] +synonym: "arylsulfate-phenol sulfotransferase activity" RELATED [EC:2.8.2.22] +synonym: "arylsulfate:phenol sulfotransferase activity" RELATED [EC:2.8.2.22] +synonym: "arylsulfotransferase" BROAD [EC:2.8.2.22] +synonym: "arylsulphate sulphotransferase activity" EXACT [] +synonym: "ASST" RELATED [EC:2.8.2.22] +xref: EC:2.8.2.22 +xref: MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN +xref: RHEA:51072 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047687 +name: obsolete ascorbate 2,3-dioxygenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-ascorbate + H(2)O + O(2) = L-threonate + 2 H(+) + oxalate." [EC:1.13.11.13, RHEA:21784] +comment: This term was made obsolete because EC:1.13.11.13 was deleted; the activity is the sum of several enzymatic and spontaneous reactions. +synonym: "AAoxygenase activity" EXACT [] +synonym: "ascorbate 2,3-dioxygenase activity" EXACT [] +synonym: "ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)" EXACT [] +xref: KEGG_REACTION:R00646 +xref: MetaCyc:ASCORBATE-23-DIOXYGENASE-RXN +xref: RHEA:21784 +is_obsolete: true + +[Term] +id: GO:0047688 +name: aspartate 4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = L-alanine + CO2." [EC:4.1.1.12, MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN] +synonym: "aminomalonic decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "aspartate beta-decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "aspartate omega-decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "aspartic beta-decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "aspartic omega-decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "cysteine sulfinic desulfinase activity" RELATED [EC:4.1.1.12] +synonym: "desulfinase activity" RELATED [EC:4.1.1.12] +synonym: "L-aspartate 4-carboxy-lyase (L-alanine-forming)" RELATED [EC:4.1.1.12] +synonym: "L-aspartate 4-carboxy-lyase activity" RELATED [EC:4.1.1.12] +synonym: "L-aspartate beta-decarboxylase activity" RELATED [EC:4.1.1.12] +synonym: "L-cysteine sulfinate acid desulfinase activity" RELATED [EC:4.1.1.12] +xref: EC:4.1.1.12 +xref: MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN +xref: RHEA:12621 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047689 +name: aspartate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate = D-aspartate." [EC:5.1.1.13, RHEA:14973] +synonym: "D-aspartate racemase activity" RELATED [EC:5.1.1.13] +xref: EC:5.1.1.13 +xref: KEGG_REACTION:R00491 +xref: MetaCyc:ASPARTATE-RACEMASE-RXN +xref: RHEA:14973 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0047690 +name: aspartyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+)." [EC:2.3.2.7, RHEA:11252] +synonym: "aspartotransferase activity" RELATED [EC:2.3.2.7] +synonym: "beta-aspartyl transferase activity" RELATED [EC:2.3.2.7] +synonym: "L-asparagine:hydroxylamine gamma-aspartyltransferase activity" RELATED [EC:2.3.2.7] +xref: EC:2.3.2.7 +xref: KEGG_REACTION:R01485 +xref: MetaCyc:ASPARTYLTRANSFERASE-RXN +xref: RHEA:11252 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0047691 +name: aspulvinone dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate." [EC:2.5.1.35, RHEA:13809] +synonym: "dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity" RELATED [EC:2.5.1.35] +synonym: "dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity" RELATED [EC:2.5.1.35] +xref: EC:2.5.1.35 +xref: KEGG_REACTION:R03799 +xref: MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN +xref: RHEA:13809 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047692 +name: ATP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ITP + NH3." [EC:3.5.4.18, MetaCyc:ATP-DEAMINASE-RXN] +synonym: "adenosine triphosphate deaminase activity" RELATED [EC:3.5.4.18] +synonym: "ATP aminohydrolase activity" RELATED [EC:3.5.4.18] +xref: EC:3.5.4.18 +xref: MetaCyc:ATP-DEAMINASE-RXN +xref: RHEA:13037 +is_a: GO:0047623 ! adenosine-phosphate deaminase activity + +[Term] +id: GO:0047693 +name: ATP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = AMP + diphosphate." [RHEA:14245] +synonym: "adenosine triphosphate pyrophosphatase activity" RELATED [EC:3.6.1.8] +synonym: "ATP diphosphohydrolase" BROAD [EC:3.6.1.8] +synonym: "ATP diphosphohydrolase (diphosphate-forming)" RELATED [EC:3.6.1.8] +synonym: "ATP pyrophosphatase activity" EXACT [] +xref: EC:3.6.1.8 +xref: MetaCyc:ATP-PYROPHOSPHATASE-RXN +xref: RHEA:14245 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0047694 +name: barbiturase activity +namespace: molecular_function +def: "Catalysis of the reaction: barbiturate + H2O = malonate + urea." [EC:3.5.2.1, MetaCyc:BARBITURASE-RXN] +synonym: "barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming)" RELATED [EC:3.5.2.1] +xref: EC:3.5.2.1 +xref: MetaCyc:BARBITURASE-RXN +xref: RHEA:18653 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047695 +name: benzoin aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoin = 2 benzaldehyde." [EC:4.1.2.38, RHEA:21460] +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity" RELATED [EC:4.1.2.38] +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming)" RELATED [EC:4.1.2.38] +synonym: "2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity" RELATED [EC:4.1.2.38] +synonym: "benzaldehyde lyase activity" RELATED [EC:4.1.2.38] +synonym: "diphenylethanone benzaldehyde-lyase activity" RELATED [EC:4.1.2.38] +xref: EC:4.1.2.38 +xref: KEGG_REACTION:R00027 +xref: MetaCyc:BENZOIN-ALDOLASE-RXN +xref: RHEA:21460 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047696 +name: beta-adrenergic receptor kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor." [EC:2.7.11.15, MetaCyc:BETA-ADRENERGIC-RECEPTOR-KINASE-RXN] +synonym: "[b-adrenergic-receptor] kinase activity" RELATED [EC:2.7.11.15] +synonym: "ADRBK1" RELATED [EC:2.7.11.15] +synonym: "adrenergic receptor kinase activity" BROAD [EC:2.7.11.15] +synonym: "ATP:beta-adrenergic-receptor phosphotransferase activity" BROAD [EC:2.7.11.15] +synonym: "BARK1" RELATED [EC:2.7.11.15] +synonym: "beta-adrenergic receptor-specific kinase activity" RELATED [EC:2.7.11.15] +synonym: "beta-adrenergic-receptor kinase (phosphorylating) activity" RELATED [EC:2.7.11.15] +synonym: "beta-adrenergic-receptor kinase activity" RELATED [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase 1 activity" NARROW [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase 2 activity" NARROW [EC:2.7.11.15] +synonym: "beta-adrenoceptor kinase activity" RELATED [EC:2.7.11.15] +synonym: "beta-AR kinase activity" RELATED [EC:2.7.11.15] +synonym: "beta-ARK" RELATED [EC:2.7.11.15] +synonym: "beta-ARK 1" RELATED [EC:2.7.11.15] +synonym: "beta-ARK 2" RELATED [EC:2.7.11.15] +synonym: "beta-receptor kinase activity" RELATED [EC:2.7.11.15] +synonym: "beta2ARK" RELATED [EC:2.7.11.15] +synonym: "betaARK1" RELATED [EC:2.7.11.15] +synonym: "GRK2" RELATED [EC:2.7.11.15] +synonym: "GRK3" RELATED [EC:2.7.11.15] +synonym: "STK15" RELATED [EC:2.7.11.15] +xref: EC:2.7.11.15 +xref: Reactome:R-HSA-8851797 "ADRB2 in ADRB2:GRK complex is phosphorylated" +xref: Reactome:R-HSA-8866268 "ADBRK1,2 phosphorylate AVPR2" +xref: RHEA:19429 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047697 +name: beta-alanopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate." [EC:1.5.1.26, RHEA:21684] +synonym: "b-alanopine dehydrogenase activity" EXACT [] +synonym: "N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)" RELATED [EC:1.5.1.26] +xref: EC:1.5.1.26 +xref: KEGG_REACTION:R00906 +xref: MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN +xref: RHEA:21684 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047698 +name: beta-alanyl-CoA ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3." [EC:4.3.1.6, MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN] +synonym: "b-alanyl-CoA ammonia-lyase activity" EXACT [] +synonym: "beta-alanyl coenzyme A ammonia-lyase activity" RELATED [EC:4.3.1.6] +synonym: "beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)" RELATED [EC:4.3.1.6] +xref: EC:4.3.1.6 +xref: MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN +xref: RHEA:12416 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047699 +name: beta-diketone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one." [EC:3.7.1.7, RHEA:11908] +synonym: "b-diketone hydrolase activity" EXACT [] +synonym: "nonane-4,6-dione acylhydrolase activity" RELATED [EC:3.7.1.7] +synonym: "oxidized PVA hydrolase activity" RELATED [EC:3.7.1.7] +xref: EC:3.7.1.7 +xref: KEGG_REACTION:R03781 +xref: MetaCyc:BETA-DIKETONE-HYDROLASE-RXN +xref: RHEA:11908 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047700 +name: beta-glucoside kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose." [EC:2.7.1.85, MetaCyc:BETA-GLUCOSIDE-KINASE-RXN] +synonym: "ATP:cellobiose 6-phosphotransferase activity" RELATED [EC:2.7.1.85] +synonym: "b-glucoside kinase activity" EXACT [] +synonym: "beta-D-glucoside kinase (phosphorylating)" RELATED [EC:2.7.1.85] +xref: EC:2.7.1.85 +xref: MetaCyc:BETA-GLUCOSIDE-KINASE-RXN +xref: RHEA:21944 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047701 +name: beta-L-arabinosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol." [EC:3.2.1.88, MetaCyc:BETA-L-ARABINOSIDASE-RXN] +synonym: "b-L-arabinosidase activity" EXACT [] +synonym: "beta-L-arabinoside arabinohydrolase activity" RELATED [EC:3.2.1.88] +synonym: "vicianosidase activity" RELATED [EC:3.2.1.88] +xref: EC:3.2.1.88 +xref: MetaCyc:BETA-L-ARABINOSIDASE-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047702 +name: beta-lysine 5,6-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate." [EC:5.4.3.3, RHEA:21736] +synonym: "(3S)-3,6-diaminohexanoate 5,6-aminomutase activity" RELATED [EC:5.4.3.3] +synonym: "b-lysine 5,6-aminomutase activity" EXACT [] +synonym: "beta-lysine mutase activity" RELATED [EC:5.4.3.3] +synonym: "L-beta-lysine 5,6-aminomutase activity" RELATED [EC:5.4.3.3] +xref: EC:5.4.3.3 +xref: KEGG_REACTION:R03275 +xref: MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN +xref: RHEA:21736 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047703 +name: beta-nitroacrylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH." [EC:1.3.1.16, RHEA:23892] +synonym: "3-nitropropanoate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.16] +synonym: "b-nitroacrylate reductase activity" EXACT [] +xref: EC:1.3.1.16 +xref: KEGG_REACTION:R03900 +xref: MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN +xref: RHEA:23892 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047704 +name: bile-salt sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] +subset: goslim_chembl +synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" RELATED [EC:2.8.2.14] +synonym: "BAST I activity" NARROW [EC:2.8.2.14] +synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] +synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" RELATED [EC:2.8.2.14] +synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" RELATED [EC:2.8.2.14] +synonym: "bile-salt sulphotransferase activity" EXACT [] +synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] +xref: EC:2.8.2.14 +xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN +xref: RHEA:14013 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047705 +name: bilirubin oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O." [EC:1.3.3.5, RHEA:20980] +synonym: "bilirubin oxidase M-1" RELATED [EC:1.3.3.5] +synonym: "bilirubin:oxygen oxidoreductase activity" RELATED [EC:1.3.3.5] +xref: EC:1.3.3.5 +xref: KEGG_REACTION:R02394 +xref: MetaCyc:BILIRUBIN-OXIDASE-RXN +xref: RHEA:20980 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0047706 +name: biochanin-A reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH." [EC:1.3.1.46, RHEA:12817] +synonym: "dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity" RELATED [EC:1.3.1.46] +xref: EC:1.3.1.46 +xref: KEGG_REACTION:R02954 +xref: MetaCyc:BIOCHANIN-A-REDUCTASE-RXN +xref: RHEA:12817 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047707 +name: biotin-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." [EC:6.2.1.11, MetaCyc:BIOTIN--COA-LIGASE-RXN] +synonym: "biotin CoA synthetase activity" RELATED [EC:6.2.1.11] +synonym: "biotin:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.11] +synonym: "biotinyl coenzyme A synthetase activity" RELATED [EC:6.2.1.11] +synonym: "biotinyl-CoA synthetase activity" RELATED [EC:6.2.1.11] +xref: EC:6.2.1.11 +xref: MetaCyc:BIOTIN--COA-LIGASE-RXN +xref: RHEA:19681 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047708 +name: biotinidase activity +namespace: molecular_function +def: "Catalysis of the reaction: biotin amide + H2O = biotin + NH3." [EC:3.5.1.12, MetaCyc:BIOTINIDASE-RXN] +synonym: "amidohydrolase biotinidase activity" RELATED [EC:3.5.1.12] +synonym: "biotin-amide amidohydrolase activity" RELATED [EC:3.5.1.12] +xref: EC:3.5.1.12 +xref: MetaCyc:BIOTINIDASE-RXN +xref: Reactome:R-HSA-3076905 "Extracellular BTD hydrolyses BCTN" +xref: Reactome:R-HSA-3325540 "Defective extracellular BTD does not hydrolyse BCTN" +xref: Reactome:R-HSA-4167509 "Mitochondrial BTD hydrolyses BCTN" +xref: Reactome:R-HSA-4225086 "Defective mitochondrial BTD does not hydrolyse BCTN" +xref: RHEA:13081 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047709 +name: bis(2-ethylhexyl)phthalate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+)." [EC:3.1.1.60, RHEA:15529] +synonym: "bis(2-ethylhexyl)phthalate acylhydrolase activity" RELATED [EC:3.1.1.60] +synonym: "DEHP esterase activity" RELATED [EC:3.1.1.60] +xref: EC:3.1.1.60 +xref: KEGG_REACTION:R04202 +xref: MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN +xref: RHEA:15529 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047710 +name: bis(5'-adenosyl)-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+)." [EC:3.6.1.29, RHEA:13893] +synonym: "1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" RELATED [EC:3.6.1.29] +synonym: "AP(3)A hydrolase activity" RELATED [EC:3.6.1.29] +synonym: "AP(3)Aase activity" RELATED [EC:3.6.1.29] +synonym: "AP3A hydrolase activity" RELATED [EC:3.6.1.29] +synonym: "AP3Aase activity" RELATED [EC:3.6.1.29] +synonym: "diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity" RELATED [EC:3.6.1.29] +synonym: "diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity" RELATED [EC:3.6.1.29] +synonym: "diadenosine 5,5-P1,P3-triphosphatase activity" RELATED [EC:3.6.1.29] +synonym: "dinucleosidetriphosphatase activity" RELATED [EC:3.6.1.29] +synonym: "P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity" RELATED [EC:3.6.1.29] +xref: EC:3.6.1.29 +xref: KEGG_REACTION:R00187 +xref: MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN +xref: RHEA:13893 +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0047711 +name: blasticidin-S deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." [EC:3.5.4.23, MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN] +synonym: "blasticidin-S aminohydrolase activity" RELATED [EC:3.5.4.23] +xref: EC:3.5.4.23 +xref: MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN +xref: RHEA:10148 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047712 +name: Cypridina-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light." [EC:1.13.12.6, MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "Cypridina luciferase activity" RELATED [EC:1.13.12.6] +synonym: "Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.6] +synonym: "Cypridina-type luciferase activity" RELATED [EC:1.13.12.6] +synonym: "luciferase (Cypridina luciferin)" RELATED [EC:1.13.12.6] +synonym: "luciferase activity" BROAD [EC:1.13.12.6] +xref: EC:1.13.12.6 +xref: MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN +xref: RHEA:22760 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0047713 +name: galactitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH." [EC:1.1.1.16, RHEA:20685] +xref: EC:1.1.1.16 +xref: KEGG_REACTION:R02928 +xref: MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN +xref: RHEA:20685 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0047714 +name: galactolipase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates." [EC:3.1.1.26, MetaCyc:GALACTOLIPASE-RXN] +synonym: "1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity" RELATED [EC:3.1.1.26] +synonym: "galactolipid acylhydrolase activity" RELATED [EC:3.1.1.26] +synonym: "galactolipid lipase activity" RELATED [EC:3.1.1.26] +synonym: "polygalactolipase activity" RELATED [EC:3.1.1.26] +xref: EC:3.1.1.26 +xref: MetaCyc:GALACTOLIPASE-RXN +xref: RHEA:13189 +is_a: GO:0016298 ! lipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047715 +name: hypotaurocyamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.6, RHEA:24008] +synonym: "ATP:hypotaurocyamine N-phosphotransferase activity" RELATED [EC:2.7.3.6] +xref: EC:2.7.3.6 +xref: KEGG_REACTION:R03939 +xref: MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN +xref: RHEA:24008 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047716 +name: imidazole N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA." [EC:2.3.1.2, RHEA:15813] +synonym: "acetyl-CoA:imidazole N-acetyltransferase activity" RELATED [EC:2.3.1.2] +synonym: "imidazole acetylase activity" RELATED [EC:2.3.1.2] +synonym: "imidazole acetyltransferase activity" RELATED [EC:2.3.1.2] +xref: EC:2.3.1.2 +xref: KEGG_REACTION:R03621 +xref: MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:15813 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047717 +name: imidazoleacetate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+)." [EC:1.14.13.5, RHEA:19425] +synonym: "4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)" RELATED [EC:1.14.13.5] +synonym: "imidazoleacetate hydroxylase activity" RELATED [EC:1.14.13.5] +synonym: "imidazoleacetic hydroxylase activity" EXACT [] +synonym: "imidazoleacetic monooxygenase activity" RELATED [EC:1.14.13.5] +xref: EC:1.14.13.5 +xref: KEGG_REACTION:R04066 +xref: MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN +xref: RHEA:19425 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047718 +name: indanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+." [EC:1.1.1.112, MetaCyc:INDANOL-DEHYDROGENASE-RXN] +synonym: "indan-1-ol:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.112] +xref: EC:1.1.1.112 +xref: MetaCyc:INDANOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047719 +name: indole 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde." [EC:1.13.11.17, RHEA:11212] +synonym: "IDO" RELATED [EC:1.13.11.17] +synonym: "indole oxidase activity" RELATED [EC:1.13.11.17] +synonym: "indole-oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.17] +synonym: "indole:O2 oxidoreductase activity" RELATED [EC:1.13.11.17] +synonym: "indole:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.17] +xref: EC:1.13.11.17 +xref: KEGG_REACTION:R02338 +xref: MetaCyc:INDOLE-23-DIOXYGENASE-RXN +xref: RHEA:11212 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047720 +name: indoleacetaldoxime dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O." [RHEA:23156] +synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]" RELATED [EC:4.99.1.6] +synonym: "(indol-3-yl)acetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.6] +synonym: "3-indoleacetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6] +synonym: "indole-3-acetaldehyde-oxime hydro-lyase activity" RELATED [EC:4.99.1.6] +synonym: "indole-3-acetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6] +synonym: "indoleacetaldoxime hydro-lyase activity" RELATED [EC:4.99.1.6] +xref: EC:4.99.1.6 +xref: KEGG_REACTION:R04093 +xref: MetaCyc:RXN-1403 +xref: RHEA:23156 +is_a: GO:0016829 ! lyase activity + +[Term] +id: GO:0047721 +name: indoleacetate-lysine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate." [EC:6.3.2.20, RHEA:14857] +synonym: "(indol-3-yl)acetate:L-lysine ligase (ADP-forming)" RELATED [EC:6.3.2.20] +synonym: "IAA-lysine synthetase activity" RELATED [EC:6.3.2.20] +synonym: "indoleacetate-lysine ligase activity" EXACT [] +synonym: "indoleacetate:L-lysine ligase (ADP-forming)" RELATED [EC:6.3.2.20] +synonym: "N-(indole-3-acetyl)-L-lysine synthetase activity" RELATED [EC:6.3.2.20] +xref: EC:6.3.2.20 +xref: KEGG_REACTION:R03095 +xref: MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN +xref: RHEA:14857 +is_a: GO:0010279 ! indole-3-acetic acid amido synthetase activity + +[Term] +id: GO:0047722 +name: indolelactate dehydrogenase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH." [RHEA:20133] +synonym: "(indol-3-yl)lactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.110] +synonym: "indole-3-lactate dehydrogenase activity" EXACT [] +synonym: "indolelactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.110] +xref: EC:1.1.1.110 +xref: KEGG_REACTION:R01971 +xref: MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN +xref: RHEA:20133 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047723 +name: inosinate nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine." [EC:3.2.2.12, RHEA:20469] +synonym: "5'-inosinate phosphoribohydrolase activity" RELATED [EC:3.2.2.12] +xref: EC:3.2.2.12 +xref: KEGG_REACTION:R01128 +xref: MetaCyc:INOSINATE-NUCLEOSIDASE-RXN +xref: RHEA:20469 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0047724 +name: inosine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine." [EC:3.2.2.2, MetaCyc:INOSINE-NUCLEOSIDASE-RXN] +synonym: "inosinase activity" RELATED [EC:3.2.2.2] +synonym: "inosine ribohydrolase activity" RELATED [EC:3.2.2.2] +synonym: "inosine-guanosine nucleosidase activity" RELATED [EC:3.2.2.2] +xref: EC:3.2.2.2 +xref: MetaCyc:INOSINE-NUCLEOSIDASE-RXN +xref: RHEA:16657 +is_a: GO:0008477 ! purine nucleosidase activity + +[Term] +id: GO:0047725 +name: inulosucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1)." [EC:2.4.1.9, MetaCyc:INULOSUCRASE-RXN] +synonym: "sucrose 1-fructosyl transferase activity" RELATED [EC:2.4.1.9] +synonym: "sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.9] +synonym: "sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.9] +xref: EC:2.4.1.9 +xref: MetaCyc:INULOSUCRASE-RXN +xref: RHEA:15745 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047726 +name: iron-cytochrome-c reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+." [EC:1.9.98.1, MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN] +synonym: "ferrocytochrome-c:Fe3+ oxidoreductase activity" RELATED [EC:1.9.98.1] +synonym: "iron-cytochrome c reductase activity" RELATED [EC:1.9.98.1] +xref: EC:1.9.98.1 +xref: MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN +xref: RHEA:15617 +is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors + +[Term] +id: GO:0047727 +name: isobutyryl-CoA mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA." [EC:5.4.99.13, RHEA:13141] +synonym: "2-methylpropanoyl-CoA CoA-carbonylmutase activity" RELATED [EC:5.4.99.13] +synonym: "butyryl-CoA:isobutyryl-CoA mutase activity" RELATED [EC:5.4.99.13] +synonym: "isobutyryl coenzyme A mutase activity" RELATED [EC:5.4.99.13] +xref: EC:5.4.99.13 +xref: KEGG_REACTION:R01181 +xref: MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN +xref: RHEA:13141 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0047728 +name: carnitine 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH." [EC:1.1.1.108, RHEA:19265] +synonym: "carnitine:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.108] +xref: EC:1.1.1.108 +xref: KEGG_REACTION:R02395 +xref: MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN +xref: RHEA:19265 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047729 +name: carnitine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2)." [EC:4.1.1.42, RHEA:21576] +synonym: "carnitine carboxy-lyase (2-methylcholine-forming)" RELATED [EC:4.1.1.42] +synonym: "carnitine carboxy-lyase activity" RELATED [EC:4.1.1.42] +xref: EC:4.1.1.42 +xref: KEGG_REACTION:R02398 +xref: MetaCyc:CARNITINE-DECARBOXYLASE-RXN +xref: RHEA:21576 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047730 +name: carnosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine." [EC:6.3.2.11, MetaCyc:CARNOSINE-SYNTHASE-RXN] +synonym: "carnosine synthetase activity" RELATED [EC:6.3.2.11] +synonym: "carnosine-anserine synthetase activity" RELATED [EC:6.3.2.11] +synonym: "carnosine-homocarnosine synthetase activity" RELATED [EC:6.3.2.11] +synonym: "homocarnosine-carnosine synthetase activity" RELATED [EC:6.3.2.11] +synonym: "L-histidine:beta-alanine ligase (AMP-forming)" RELATED [EC:6.3.2.11] +xref: EC:6.3.2.11 +xref: MetaCyc:CARNOSINE-SYNTHASE-RXN +xref: Reactome:R-HSA-6786245 "CARNS1 transforms ATP, L-His, b-Ala to CARN" +xref: RHEA:19297 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047731 +name: catechol oxidase (dimerizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O." [EC:1.1.3.14, MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN] +synonym: "catechol:oxygen oxidoreductase (dimerizing)" RELATED [EC:1.1.3.14] +xref: EC:1.1.3.14 +xref: MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN +xref: RHEA:12809 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047732 +name: CDP-abequose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose." [EC:5.1.3.10, RHEA:21656] +synonym: "CDP-3,6-dideoxy-D-glucose 2-epimerase activity" RELATED [EC:5.1.3.10] +synonym: "CDP-D-abequose 2-epimerase activity" RELATED [EC:5.1.3.10] +synonym: "CDP-paratose 2-epimerase activity" RELATED [EC:5.1.3.10] +synonym: "CDP-paratose epimerase activity" RELATED [EC:5.1.3.10] +synonym: "CDP-tyvelose 2-epimerase activity" RELATED [EC:5.1.3.10] +synonym: "cytidine diphosphate paratose-2-epimerase activity" RELATED [EC:5.1.3.10] +synonym: "cytidine diphosphoabequose epimerase activity" RELATED [EC:5.1.3.10] +synonym: "cytidine diphosphodideoxyglucose epimerase activity" RELATED [EC:5.1.3.10] +synonym: "cytidine diphosphoparatose epimerase activity" RELATED [EC:5.1.3.10] +xref: EC:5.1.3.10 +xref: KEGG_REACTION:R04266 +xref: MetaCyc:RXN-9160 +xref: RHEA:21656 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047733 +name: CDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O." [EC:4.2.1.45, RHEA:17153] +synonym: "CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.45] +synonym: "CDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.45] +synonym: "CDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.45] +synonym: "CDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.45] +synonym: "cytidine diphosphoglucose oxidoreductase activity" RELATED [EC:4.2.1.45] +xref: EC:4.2.1.45 +xref: KEGG_REACTION:R02426 +xref: MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN +xref: RHEA:17153 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047734 +name: CDP-glycerol diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+)." [EC:3.6.1.16, RHEA:21692] +synonym: "CDP-glycerol phosphoglycerohydrolase activity" RELATED [EC:3.6.1.16] +synonym: "CDP-glycerol pyrophosphatase activity" EXACT [] +synonym: "CDPglycerol diphosphatase activity" RELATED [EC:3.6.1.16] +synonym: "CDPglycerol phosphoglycerohydrolase activity" RELATED [EC:3.6.1.16] +synonym: "CDPglycerol pyrophosphatase activity" RELATED [EC:3.6.1.16] +synonym: "cytidine diphosphoglycerol pyrophosphatase activity" RELATED [EC:3.6.1.16] +xref: EC:3.6.1.16 +xref: KEGG_REACTION:R00855 +xref: MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN +xref: RHEA:21692 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047735 +name: cellobiose dehydrogenase (acceptor) activity +namespace: molecular_function +alt_id: GO:0047737 +def: "Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor." [EC:1.1.99.18, MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN] +synonym: "CBOR activity" RELATED [EC:1.1.99.18] +synonym: "CDH activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose dehydrogenase (quinone) activity" NARROW [EC:1.1.99.18] +synonym: "cellobiose dehydrogenase activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose oxidase activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose oxidoreductase activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose-quinone oxidoreductase activity" NARROW [EC:1.1.99.18] +synonym: "cellobiose:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.18] +synonym: "cellobiose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.99.18] +synonym: "phanerochaete chrysosporium cellobiose oxidoreductase activity" RELATED [EC:1.1.99.18] +xref: EC:1.1.99.18 +xref: MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN +xref: RHEA:23484 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047736 +name: cellobiose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose." [EC:5.1.3.11, MetaCyc:CELLOBIOSE-EPIMERASE-RXN] +synonym: "cellobiose 2-epimerase activity" RELATED [EC:5.1.3.11] +xref: EC:5.1.3.11 +xref: MetaCyc:CELLOBIOSE-EPIMERASE-RXN +xref: RHEA:23384 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047738 +name: cellobiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose." [EC:2.4.1.20, MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN] +synonym: "cellobiose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.20] +xref: EC:2.4.1.20 +xref: MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN +xref: RHEA:19493 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0047739 +name: cephalosporin-C deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+)." [EC:3.1.1.41, RHEA:22596] +synonym: "cephalosporin acetylesterase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin C acetyl-esterase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin C acetyl-hydrolase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin C acetylase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin C acetylesterase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin C deacetylase activity" RELATED [EC:3.1.1.41] +synonym: "cephalosporin-C acetylhydrolase activity" RELATED [EC:3.1.1.41] +xref: EC:3.1.1.41 +xref: KEGG_REACTION:R03062 +xref: MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN +xref: RHEA:22596 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047740 +name: cephalosporin-C transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C." [EC:2.6.1.74, RHEA:14553] +synonym: "cephalosporin C aminotransferase activity" RELATED [EC:2.6.1.74] +synonym: "cephalosporin-C:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.74] +synonym: "L-alanine:cephalosporin-C aminotransferase activity" RELATED [EC:2.6.1.74] +xref: EC:2.6.1.74 +xref: KEGG_REACTION:R03063 +xref: MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN +xref: RHEA:14553 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047741 +name: cetraxate benzylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+)." [EC:3.1.1.70, RHEA:23460] +synonym: "cetraxate-benzyl-ester benzylhydrolase activity" RELATED [EC:3.1.1.70] +xref: EC:3.1.1.70 +xref: KEGG_REACTION:R03612 +xref: MetaCyc:CETRAXATE-BENZYLESTERASE-RXN +xref: RHEA:23460 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047742 +name: chenodeoxycholoyltaurine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine." [EC:3.5.1.74, MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN] +synonym: "chenodeoxycholoyltaurine amidohydrolase activity" RELATED [EC:3.5.1.74] +xref: EC:3.5.1.74 +xref: MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN +xref: RHEA:16309 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047743 +name: chlordecone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH." [EC:1.1.1.225, RHEA:14401] +synonym: "CDR activity" RELATED [EC:1.1.1.225] +synonym: "chlordecone-alcohol:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.225] +xref: EC:1.1.1.225 +xref: KEGG_REACTION:R03716 +xref: MetaCyc:CHLORDECONE-REDUCTASE-RXN +xref: RHEA:14401 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047744 +name: chloridazon-catechol dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)." [EC:1.13.11.36, RHEA:20449] +synonym: "5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.36] +xref: EC:1.13.11.36 +xref: KEGG_REACTION:R04602 +xref: MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN +xref: RHEA:20449 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047745 +name: chlorogenate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+)." [EC:3.1.1.42, RHEA:20689] +synonym: "chlorogenase activity" RELATED [EC:3.1.1.42] +synonym: "chlorogenic acid esterase activity" RELATED [EC:3.1.1.42] +xref: EC:3.1.1.42 +xref: KEGG_REACTION:R02997 +xref: MetaCyc:CHLOROGENATE-HYDROLASE-RXN +xref: RHEA:20689 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047746 +name: chlorophyllase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide." [EC:3.1.1.14, MetaCyc:CHLOROPHYLLASE-RXN] +synonym: "chlorophyll chlorophyllidohydrolase activity" RELATED [EC:3.1.1.14] +xref: EC:3.1.1.14 +xref: MetaCyc:CHLOROPHYLLASE-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047747 +name: cholate-CoA ligase activity +namespace: molecular_function +alt_id: GO:0047477 +def: "Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA." [EC:6.2.1.7] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity" EXACT [] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity" RELATED [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.29] +synonym: "3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity" RELATED [EC:6.2.1.29] +synonym: "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity" RELATED [EC:6.2.1.29] +synonym: "BAL activity" RELATED [EC:6.2.1.29] +synonym: "bile acid CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "bile acid coenzyme A ligase activity" RELATED [EC:6.2.1.29] +synonym: "cholate thiokinase activity" RELATED [EC:6.2.1.29] +synonym: "cholate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.29] +synonym: "cholic acid:CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "cholic thiokinase activity" RELATED [EC:6.2.1.29] +synonym: "choloyl coenzyme A synthetase activity" RELATED [EC:6.2.1.29] +synonym: "choloyl-CoA synthetase activity" RELATED [EC:6.2.1.29] +synonym: "cholyl-CoA synthetase activity" RELATED [EC:6.2.1.29] +synonym: "THCA-CoA ligase activity" RELATED [EC:6.2.1.29] +synonym: "trihydroxycoprostanoyl-CoA synthetase activity" RELATED [EC:6.2.1.29] +xref: EC:6.2.1.7 +xref: MetaCyc:CHOLATE--COA-LIGASE-RXN +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047748 +name: cholestanetetraol 26-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH." [RHEA:34631] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity" EXACT [] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity" EXACT [] +synonym: "cholestanetetrol 26-dehydrogenase activity" EXACT [] +synonym: "TEHC-NAD oxidoreductase activity" EXACT [] +xref: MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN +xref: RHEA:34631 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047749 +name: cholestanetriol 26-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O." [EC:1.14.15.15, MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN] +synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity" RELATED [EC:1.14.15.15] +synonym: "5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity" BROAD [EC:1.14.15.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity" RELATED [EC:1.14.15.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity" RELATED [EC:1.14.15.15] +synonym: "5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)" RELATED [EC:1.14.15.15] +synonym: "cholestanetriol 26-hydroxylase activity" RELATED [EC:1.14.15.15] +synonym: "cholesterol 27-hydroxylase activity" RELATED [EC:1.14.15.15] +synonym: "CYP27A" RELATED [] +synonym: "CYP27A1" RELATED [] +synonym: "cytochrome P450 27A1' activity" NARROW [EC:1.14.15.15] +synonym: "sterol 26-hydroxylase activity" BROAD [EC:1.14.15.15] +synonym: "sterol 27-hydroxylase activity" RELATED [EC:1.14.15.15] +xref: EC:1.14.15.15 +xref: MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN +xref: RHEA:14373 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047750 +name: cholestenol delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol." [EC:5.3.3.5, MetaCyc:CHOLESTENOL-DELTA-ISOMERASE-RXN] +synonym: "cholestenol D-isomerase activity" EXACT [] +synonym: "delta7-cholestenol delta7-delta8-isomerase activity" RELATED [EC:5.3.3.5] +xref: EC:5.3.3.5 +xref: MetaCyc:RXN66-25 +xref: RHEA:15281 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0047751 +name: cholestenone 5-alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH." [EC:1.3.1.22, RHEA:24552] +synonym: "3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity" RELATED [EC:1.3.1.22] +synonym: "3-oxosteroid 5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.1.22] +synonym: "4-ene-3-oxosteroid 5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "4-ene-5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "cholest-4-en-3-one 5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "cholestenone 5a-reductase activity" EXACT [] +synonym: "cholestenone 5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "delta4-3-ketosteroid 5alpha-oxidoreductase activity" RELATED [EC:1.3.1.22] +synonym: "reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity" RELATED [EC:1.3.1.22] +synonym: "steroid 5alpha-hydrogenase activity" RELATED [EC:1.3.1.22] +synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.1.22] +synonym: "testosterone delta4-5alpha-reductase activity" RELATED [EC:1.3.1.22] +synonym: "testosterone delta4-hydrogenase activity" RELATED [EC:1.3.1.22] +xref: EC:1.3.1.22 +xref: KEGG_REACTION:R02610 +xref: MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN +xref: RHEA:24552 +is_a: GO:0035671 ! enone reductase activity + +[Term] +id: GO:0047753 +name: choline-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate." [EC:3.1.6.6, RHEA:20820] +synonym: "choline-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.6] +synonym: "choline-sulphatase activity" EXACT [] +xref: EC:3.1.6.6 +xref: KEGG_REACTION:R01028 +xref: MetaCyc:CHOLINE-SULFATASE-RXN +xref: RHEA:20820 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047754 +name: choline sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+)." [EC:2.8.2.6, RHEA:21984] +synonym: "3'-phosphoadenylyl-sulfate:choline sulfotransferase activity" RELATED [EC:2.8.2.6] +synonym: "choline sulphokinase activity" RELATED [EC:2.8.2.6] +synonym: "choline sulphotransferase activity" EXACT [] +xref: EC:2.8.2.6 +xref: KEGG_REACTION:R01027 +xref: MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN +xref: RHEA:21984 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047755 +name: isocitrate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate." [EC:5.1.2.6, RHEA:10820] +synonym: "(1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity" RELATED [EC:5.1.2.6] +xref: EC:5.1.2.6 +xref: KEGG_REACTION:R02318 +xref: MetaCyc:ISOCITRATE-EPIMERASE-RXN +xref: RHEA:10820 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0047756 +name: chondroitin 4-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate." [EC:2.8.2.5, MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity" RELATED [EC:2.8.2.5] +synonym: "chondroitin 4-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.5 +xref: MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-1971483 "Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13" +xref: RHEA:16101 +is_a: GO:0034481 ! chondroitin sulfotransferase activity + +[Term] +id: GO:0047757 +name: chondroitin-glucuronate 5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate." [EC:5.1.3.19, MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN] +synonym: "chondroitin D-glucuronosyl 5-epimerase activity" RELATED [EC:5.1.3.19] +synonym: "chondroitin-D-glucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] +synonym: "dermatan-sulfate 5-epimerase activity" RELATED [EC:5.1.3.19] +synonym: "polyglucuronate 5-epimerase activity" RELATED [EC:5.1.3.19] +synonym: "urunosyl C-5 epimerase activity" RELATED [EC:5.1.3.19] +xref: EC:5.1.3.19 +xref: MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN +xref: Reactome:R-HSA-2022052 "Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)" +xref: RHEA:21084 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047758 +name: ATP:2-methylpropanoate phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+)." [EC:2.7.2.14, RHEA:24156] +synonym: "ATP:2-methylpropanoate 1-phosphotransferase activity" EXACT [] +synonym: "ATP:2-methylpropanoate kinase activity" EXACT [] +synonym: "ATP:branched-chain-fatty-acid 1-phosphotransferase activity" BROAD [EC:2.7.2.14, KEGG_REACTION:R04002] +synonym: "ATP:isobutyrate 1-phosphotransferase activity" EXACT [] +synonym: "branched-chain fatty acid kinase activity" BROAD [EC:2.7.2.14] +synonym: "branched-chain-fatty-acid kinase activity" BROAD [EC:2.7.2.14] +synonym: "isobutyrate kinase activity" BROAD [EC:2.7.2.14] +xref: EC:2.7.2.14 +xref: KEGG_REACTION:R04002 +xref: MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN +xref: RHEA:24156 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047759 +name: butanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+." [EC:1.2.1.57, MetaCyc:BUTANAL-DEHYDROGENASE-RXN] +synonym: "butanal:NAD(P)+ oxidoreductase (CoA-acylating)" RELATED [EC:1.2.1.57] +xref: EC:1.2.1.57 +xref: MetaCyc:BUTANAL-DEHYDROGENASE-RXN +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047760 +name: butyrate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA." [EC:6.2.1.2, MetaCyc:BUTYRATE--COA-LIGASE-RXN] +synonym: "acyl-activating enzyme activity" RELATED [EC:6.2.1.2] +synonym: "butanoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.2] +synonym: "butyryl-CoA synthetase activity" RELATED [EC:6.2.1.2] +synonym: "butyryl-coenzyme A synthetase activity" RELATED [EC:6.2.1.2] +synonym: "fatty acid activating enzyme" RELATED [EC:6.2.1.2] +synonym: "fatty acid thiokinase (medium chain) activity" RELATED [EC:6.2.1.2] +synonym: "fatty acyl coenzyme A synthetase activity" RELATED [EC:6.2.1.2] +synonym: "L-(+)-3-hydroxybutyryl CoA ligase activity" RELATED [EC:6.2.1.2] +synonym: "medium chain acyl-CoA synthetase activity" RELATED [EC:6.2.1.2] +synonym: "short-chain acyl-CoA synthetase activity" RELATED [EC:6.2.1.2] +xref: EC:6.2.1.2 +xref: MetaCyc:BUTYRATE--COA-LIGASE-RXN +xref: Reactome:R-HSA-8875013 "ACSM3,ACSM6 ligate CoA to BUT" +xref: RHEA:24336 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047761 +name: butyrate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+)." [EC:2.7.2.7, RHEA:13585] +synonym: "ATP:butanoate 1-phosphotransferase activity" RELATED [EC:2.7.2.7] +xref: EC:2.7.2.7 +xref: KEGG_REACTION:R01688 +xref: MetaCyc:BUTYRATE-KINASE-RXN +xref: RHEA:13585 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047762 +name: caffeate 3,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)." [EC:1.13.11.22, RHEA:22216] +synonym: "3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.22] +xref: EC:1.13.11.22 +xref: KEGG_REACTION:R03365 +xref: MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN +xref: RHEA:22216 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047763 +name: caffeate O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." [EC:2.1.1.68, MetaCyc:CAFFEATE-O-METHYLTRANSFERASE-RXN] +synonym: "caffeate 3-O-methyltransferase activity" RELATED [EC:2.1.1.68] +synonym: "caffeate methyltransferase activity" RELATED [EC:2.1.1.68] +synonym: "S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity" RELATED [EC:2.1.1.68] +synonym: "S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity" RELATED [EC:2.1.1.68] +xref: EC:2.1.1.68 +xref: MetaCyc:RXN-1104 +xref: RHEA:20225 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0047764 +name: obsolete caldesmon kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + caldesmon = ADP + caldesmon phosphate." [GOC:curators] +comment: This term was made obsolete because it represents a specific gene product. +xref: MetaCyc:2.7.11.17-RXN +is_obsolete: true + +[Term] +id: GO:0047765 +name: caldesmon-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate." [EC:3.1.3.55, MetaCyc:CALDESMON-PHOSPHATASE-RXN] +synonym: "caldesmon-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.55] +synonym: "smooth muscle caldesmon phosphatase activity" RELATED [EC:3.1.3.55] +synonym: "SMP-I" RELATED [EC:3.1.3.55] +xref: EC:3.1.3.55 +xref: MetaCyc:CALDESMON-PHOSPHATASE-RXN +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047766 +name: carbamoyl-serine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate." [EC:4.3.1.13, RHEA:15445] +synonym: "carbamoylserine deaminase activity" RELATED [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)" RELATED [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.13] +synonym: "O-carbamoyl-L-serine deaminase activity" RELATED [EC:4.3.1.13] +xref: EC:4.3.1.13 +xref: KEGG_REACTION:R00213 +xref: MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN +xref: RHEA:15445 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047768 +name: carboxy-cis,cis-muconate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate." [EC:5.5.1.5, RHEA:14977] +synonym: "3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" RELATED [EC:5.5.1.5] +synonym: "3-carboxy-cis,cis-muconate lactonizing enzyme activity" RELATED [EC:5.5.1.5] +synonym: "3-carboxymuconate cyclase activity" RELATED [EC:5.5.1.5] +xref: EC:5.5.1.5 +xref: KEGG_REACTION:R03308 +xref: MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN +xref: RHEA:14977 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047769 +name: arogenate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2." [EC:4.2.1.91, MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN] +synonym: "carboxycyclohexadienyl dehydratase activity" EXACT [] +synonym: "L-arogenate hydro-lyase (decarboxylating)" RELATED [EC:4.2.1.91] +synonym: "L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)" RELATED [EC:4.2.1.91] +xref: EC:4.2.1.91 +xref: MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN +xref: RHEA:12536 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047770 +name: carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor." [EC:1.2.99.6, MetaCyc:CARBOXYLATE-REDUCTASE-RXN] +synonym: "aldehyde:(acceptor) oxidoreductase activity" RELATED [EC:1.2.99.6] +synonym: "aldehyde:acceptor oxidoreductase activity" RELATED [EC:1.2.99.6] +synonym: "carboxylic acid reductase activity" RELATED [EC:1.2.99.6] +xref: EC:1.2.99.6 +xref: MetaCyc:CARBOXYLATE-REDUCTASE-RXN +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047771 +name: carboxymethylhydantoinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.4, RHEA:12028] +synonym: "hydantoin hydrolase activity" RELATED [EC:3.5.2.4] +synonym: "L-5-carboxymethylhydantoin amidohydrolase activity" RELATED [EC:3.5.2.4] +xref: EC:3.5.2.4 +xref: KEGG_REACTION:R02284 +xref: MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN +xref: RHEA:12028 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047772 +name: carboxymethyloxysuccinate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate." [EC:4.2.99.12, RHEA:12336] +synonym: "carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)" RELATED [EC:4.2.99.12] +synonym: "carboxymethyloxysuccinate glycolate-lyase activity" RELATED [EC:4.2.99.12] +xref: EC:4.2.99.12 +xref: KEGG_REACTION:R01336 +xref: MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN +xref: RHEA:12336 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0047773 +name: carnitinamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+)." [EC:3.5.1.73, RHEA:17537] +synonym: "carnitine amidase activity" RELATED [EC:3.5.1.73] +synonym: "L-carnitinamidase activity" RELATED [EC:3.5.1.73] +synonym: "L-carnitinamide amidohydrolase activity" RELATED [EC:3.5.1.73] +synonym: "L-carnitine amidase activity" RELATED [EC:3.5.1.73] +xref: EC:3.5.1.73 +xref: KEGG_REACTION:R01922 +xref: MetaCyc:CARNITINAMIDASE-RXN +xref: RHEA:17537 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047774 +name: cis-2-enoyl-CoA reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH." [EC:1.3.1.37, MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN] +synonym: "acyl-CoA:NADP+ cis-2-oxidoreductase activity" RELATED [EC:1.3.1.37] +synonym: "cis-2-enoyl-coenzyme A reductase activity" RELATED [EC:1.3.1.37] +synonym: "NADPH-dependent cis-enoyl-CoA reductase activity" RELATED [EC:1.3.1.37] +synonym: "reductase, cis-2-enoyl coenzyme A" RELATED [EC:1.3.1.37] +xref: EC:1.3.1.37 +xref: MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047775 +name: citramalate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA." [EC:2.8.3.11, MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN] +synonym: "acetyl-CoA:citramalate CoA-transferase activity" RELATED [EC:2.8.3.11] +xref: EC:2.8.3.11 +xref: MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN +xref: RHEA:17621 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0047776 +name: citramalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-citramalate = acetate + pyruvate." [EC:4.1.3.22, RHEA:15545] +synonym: "(+)-citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22] +synonym: "(3S)-citramalate pyruvate-lyase (acetate-forming)" RELATED [EC:4.1.3.22] +synonym: "(3S)-citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22] +synonym: "(S)-citramalate lyase activity" RELATED [EC:4.1.3.22] +synonym: "citramalate pyruvate lyase activity" RELATED [EC:4.1.3.22] +synonym: "citramalate pyruvate-lyase activity" RELATED [EC:4.1.3.22] +synonym: "citramalate synthetase activity" RELATED [EC:4.1.3.22] +synonym: "citramalic synthase activity" RELATED [EC:4.1.3.22] +synonym: "citramalic-condensing enzyme" RELATED [EC:4.1.3.22] +xref: EC:4.1.3.22 +xref: KEGG_REACTION:R00325 +xref: MetaCyc:CITRAMALATE-LYASE-RXN +xref: RHEA:15545 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047777 +name: (S)-citramalyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate." [EC:4.1.3.25, RHEA:22612] +synonym: "(+)-CMA-CoA lyase activity" RELATED [EC:4.1.3.25] +synonym: "(3S)-citramalyl-CoA lyase activity" RELATED [EC:4.1.3.25] +synonym: "(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.25] +synonym: "(3S)-citramalyl-CoA pyruvate-lyase activity" RELATED [EC:4.1.3.25] +synonym: "citramalyl coenzyme A lyase activity" RELATED [EC:4.1.3.25] +synonym: "citramalyl-CoA lyase activity" BROAD [] +xref: EC:4.1.3.25 +xref: KEGG_REACTION:R00237 +xref: MetaCyc:CITRAMALYL-COA-LYASE-RXN +xref: RHEA:22612 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0047778 +name: [citrate-(pro-3S)-lyase] thiolesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate." [EC:3.1.2.16, MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN] +synonym: "[citrate-(pro-3S)-lyase] thioesterase activity" RELATED [EC:3.1.2.16] +synonym: "citrate (pro-3S)-lyase thiolesterase activity" EXACT [] +synonym: "citrate lyase deacetylase activity" RELATED [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase thioesterase activity" RELATED [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase thiolesterase activity" RELATED [EC:3.1.2.16] +synonym: "citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity" RELATED [EC:3.1.2.16] +xref: EC:3.1.2.16 +xref: MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN +xref: RHEA:13657 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0047779 +name: citrate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate." [EC:6.2.1.18, RHEA:21472] +synonym: "citrate thiokinase activity" RELATED [EC:6.2.1.18] +synonym: "citrate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.18] +synonym: "citrate:CoA ligase activity" RELATED [EC:6.2.1.18] +synonym: "citryl-CoA synthetase activity" RELATED [EC:6.2.1.18] +xref: EC:6.2.1.18 +xref: KEGG_REACTION:R01322 +xref: MetaCyc:CITRATE--COA-LIGASE-RXN +xref: RHEA:21472 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047780 +name: citrate dehydratase activity +namespace: molecular_function +alt_id: GO:0052632 +def: "Catalysis of the reaction: citrate = cis-aconitate + H2O." [EC:4.2.1.3] +comment: This term is also a sub-reaction of 'aconitate hydratase activity ; GO:0003994 (EC:4.2.1.3)'. +synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] +synonym: "citrate hydro-lyase (cis-aconitate-forming)" RELATED [EC:4.2.1.3] +synonym: "citrate hydro-lyase (cis-aconitate-forming) activity" EXACT [] +synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] +xref: EC:4.2.1.3 +xref: KEGG_REACTION:R01325 +xref: MetaCyc:ACONITATEDEHYDR-RXN +xref: MetaCyc:CITRATE-DEHYDRATASE-RXN +xref: RHEA:10228 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047781 +name: citrullinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine." [EC:3.5.1.20, MetaCyc:CITRULLINASE-RXN] +synonym: "citrulline hydrolase activity" RELATED [EC:3.5.1.20] +synonym: "citrulline ureidase activity" RELATED [EC:3.5.1.20] +synonym: "L-citrulline 5-N-carbamoyldihydrolase activity" RELATED [EC:3.5.1.20] +synonym: "L-citrulline N5-carbamoyldihydrolase activity" RELATED [EC:3.5.1.20] +xref: EC:3.5.1.20 +xref: MetaCyc:CITRULLINASE-RXN +xref: RHEA:11940 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047782 +name: coniferin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol." [EC:3.2.1.126, MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN] +synonym: "coniferin b-glucosidase activity" EXACT [] +synonym: "coniferin beta-D-glucosidase activity" RELATED [EC:3.2.1.126] +synonym: "coniferin-hydrolyzing beta-glucosidase activity" RELATED [EC:3.2.1.126] +xref: EC:3.2.1.126 +xref: MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN +xref: RHEA:12252 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0047783 +name: corticosterone 18-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.5, MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN] +synonym: "corticosterone 18-hydroxylase activity" EXACT [] +synonym: "corticosterone methyl oxidase activity" RELATED [EC:1.14.15.5] +synonym: "corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)" RELATED [EC:1.14.15.5] +xref: EC:1.14.15.5 +xref: MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN +xref: RHEA:11872 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047784 +name: cortisol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate." [EC:2.3.1.27, RHEA:17073] +synonym: "acetyl-CoA:cortisol O-acetyltransferase activity" RELATED [EC:2.3.1.27] +synonym: "corticosteroid acetyltransferase activity" RELATED [EC:2.3.1.27] +synonym: "corticosteroid-21-O-acetyltransferase activity" RELATED [EC:2.3.1.27] +synonym: "cortisol acetyltransferase activity" RELATED [EC:2.3.1.27] +xref: EC:2.3.1.27 +xref: KEGG_REACTION:R02837 +xref: MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN +xref: RHEA:17073 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0047785 +name: cortisol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+)." [EC:2.8.2.18, RHEA:11884] +synonym: "3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity" RELATED [EC:2.8.2.18] +synonym: "cortisol sulphotransferase activity" EXACT [] +synonym: "glucocorticoid sulfotransferase activity" RELATED [EC:2.8.2.18] +synonym: "glucocorticosteroid sulfotransferase activity" BROAD [EC:2.8.2.18] +xref: EC:2.8.2.18 +xref: KEGG_REACTION:R02839 +xref: MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN +xref: RHEA:11884 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047786 +name: cortisone alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH." [RHEA:17981] +synonym: "4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity" RELATED [] +synonym: "cortisone a-reductase activity" EXACT [] +synonym: "cortisone delta4-5alpha-reductase activity" RELATED [] +synonym: "delta4-3-ketosteroid reductase (5alpha)" RELATED [EC:1.3.1.4] +synonym: "delta4-3-oxosteroid-5alpha-reductase" RELATED [] +synonym: "delta4-5alpha-reductase activity" RELATED [] +synonym: "microsomal steroid reductase (5alpha)" RELATED [EC:1.3.1.4] +synonym: "NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity" RELATED [] +xref: KEGG_REACTION:R02892 +xref: MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN +xref: RHEA:17981 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047787 +name: delta4-3-oxosteroid 5beta-reductase activity +namespace: molecular_function +alt_id: GO:0047752 +def: "Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+." [EC:1.3.1.3, MetaCyc:CORTISONE-BETA-REDUCTASE-RXN] +synonym: "3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity" RELATED [EC:1.3.1.23] +synonym: "3-oxo-Delta(4)-steroid 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "3-oxo-delta4-steroid 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity" RELATED [EC:1.3.1.23] +synonym: "5-beta-reductase activity" BROAD [EC:1.3.1.23] +synonym: "5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity" RELATED [EC:1.3.1.23] +synonym: "5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "androstenedione 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "androstenedione 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "cholestenone 5-beta-reductase activity" EXACT [] +synonym: "cholestenone 5b-reductase activity" EXACT [] +synonym: "cholestenone 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "cortisone 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "cortisone 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "cortisone b-reductase activity" EXACT [] +synonym: "cortisone beta-reductase activity" EXACT [] +synonym: "cortisone delta(4)-5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "cortisone delta4-5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "delta(4)-3-ketosteroid 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "delta(4)-5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "delta(4)-hydrogenase activity" RELATED [EC:1.3.1.23] +synonym: "delta4-3-ketosteroid 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "delta4-3-oxosteroid 5-beta-reductase activity" EXACT [] +synonym: "delta4-5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "delta4-hydrogenase activity" RELATED [EC:1.3.1.23] +synonym: "steroid 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "steroid 5beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "testosterone 5-beta-reductase activity" RELATED [EC:1.3.1.23] +synonym: "testosterone 5beta-reductase activity" RELATED [EC:1.3.1.23] +xref: EC:1.3.1.3 +xref: MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN +xref: MetaCyc:CORTISONE-BETA-REDUCTASE-RXN +is_a: GO:0035671 ! enone reductase activity + +[Term] +id: GO:0047788 +name: 2-coumarate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH." [EC:1.3.1.11, RHEA:21444] +synonym: "3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.11] +synonym: "coumarate reductase activity" EXACT [] +synonym: "melilotate dehydrogenase activity" RELATED [EC:1.3.1.11] +xref: EC:1.3.1.11 +xref: KEGG_REACTION:R03709 +xref: MetaCyc:COUMARATE-REDUCTASE-RXN +xref: RHEA:21444 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047789 +name: creatininase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatinine + H(2)O = creatine." [EC:3.5.2.10, RHEA:14533] +synonym: "creatinine amidohydrolase activity" RELATED [EC:3.5.2.10] +synonym: "creatinine hydrolase" BROAD [EC:3.5.2.10] +xref: EC:3.5.2.10 +xref: KEGG_REACTION:R01884 +xref: MetaCyc:CREATININASE-RXN +xref: RHEA:14533 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0047790 +name: creatinine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3." [EC:3.5.4.21, MetaCyc:CREATININE-DEAMINASE-RXN] +synonym: "creatinine desiminase activity" RELATED [EC:3.5.4.21] +synonym: "creatinine hydrolase" BROAD [EC:3.5.4.21] +synonym: "creatinine iminohydrolase activity" RELATED [EC:3.5.4.21] +xref: EC:3.5.4.21 +xref: MetaCyc:CREATININE-DEAMINASE-RXN +xref: RHEA:12681 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047791 +name: cucurbitacin delta23-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+." [EC:1.3.1.5, MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN] +synonym: "23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity" RELATED [EC:1.3.1.5] +synonym: "cucurbitacin D23-reductase activity" EXACT [] +synonym: "cucurbitacin delta(23) reductase activity" EXACT [] +synonym: "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity" RELATED [EC:1.3.1.5] +xref: EC:1.3.1.5 +xref: MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047792 +name: cyanohydrin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside." [EC:2.4.1.85, MetaCyc:CYANOHYDRIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "cyanohydrin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "UGT85B1 activity" NARROW [EC:2.4.1.85] +synonym: "uridine diphosphoglucose-cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity" RELATED [EC:2.4.1.85] +synonym: "uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.85] +xref: EC:2.4.1.85 +xref: RHEA:12853 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047793 +name: cycloeucalenol cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: cycloeucalenol = obtusifoliol." [EC:5.5.1.9, RHEA:22800] +synonym: "cycloeucalenol lyase (cyclopropane-decyclizing)" RELATED [EC:5.5.1.9] +synonym: "cycloeucalenol--obtusifoliol isomerase activity" RELATED [EC:5.5.1.9] +synonym: "cycloeucalenol-obtusifoliol isomerase activity" EXACT [] +xref: EC:5.5.1.9 +xref: KEGG_REACTION:R03775 +xref: MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN +xref: RHEA:22800 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047794 +name: cyclohexadienyl dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2." [EC:1.3.1.43, MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN] +synonym: "arogenate dehydrogenase activity" RELATED [EC:1.3.1.43] +synonym: "arogenic dehydrogenase activity" RELATED [EC:1.3.1.43] +synonym: "L-arogenate:NAD(+) oxidoreductase activity" RELATED [EC:1.3.1.43] +synonym: "L-arogenate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.3.1.43] +synonym: "L-arogenate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.43] +synonym: "pretyrosine dehydrogenase activity" RELATED [EC:1.3.1.43] +xref: EC:1.3.1.43 +xref: MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN +xref: RHEA:12256 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047795 +name: cyclohexane-1,2-diol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH." [EC:1.1.1.174, MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN] +synonym: "trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.174] +xref: EC:1.1.1.174 +xref: MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN +xref: RHEA:18141 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047796 +name: cyclohexane-1,3-dione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+)." [EC:3.7.1.10, RHEA:16473] +synonym: "1,3-cyclohexanedione hydrolase activity" RELATED [EC:3.7.1.10] +synonym: "cyclohexane-1,3-dione acylhydrolase (decyclizing)" RELATED [EC:3.7.1.10] +xref: EC:3.7.1.10 +xref: KEGG_REACTION:R03211 +xref: MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN +xref: RHEA:16473 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0047797 +name: cyclohexanone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone." [EC:1.3.99.14, RHEA:21780] +synonym: "cyclohexanone:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.3.99.14] +synonym: "cyclohexanone:acceptor 2-oxidoreductase activity" RELATED [EC:1.3.99.14] +xref: EC:1.3.99.14 +xref: KEGG_REACTION:R02234 +xref: MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN +xref: RHEA:21780 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0047798 +name: cyclomaltodextrinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin." [EC:3.2.1.54, MetaCyc:CYCLOMALTODEXTRINASE-RXN] +synonym: "cyclodextrinase activity" RELATED [EC:3.2.1.54] +synonym: "cycloheptaglucanase activity" RELATED [EC:3.2.1.54] +synonym: "cyclohexaglucanase activity" RELATED [EC:3.2.1.54] +synonym: "cyclomaltodextrin dextrin-hydrolase (decyclizing)" RELATED [EC:3.2.1.54] +xref: EC:3.2.1.54 +xref: MetaCyc:CYCLOMALTODEXTRINASE-RXN +xref: RHEA:23980 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047799 +name: cyclopentanone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+)." [EC:1.14.13.16, RHEA:15737] +synonym: "cyclopentanone 1,2-monooxygenase activity" RELATED [EC:1.14.13.16] +synonym: "cyclopentanone oxygenase activity" RELATED [EC:1.14.13.16] +synonym: "cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing)" RELATED [EC:1.14.13.16] +xref: EC:1.14.13.16 +xref: KEGG_REACTION:R02554 +xref: MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN +xref: RHEA:15737 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047800 +name: cysteamine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine." [EC:1.13.11.19, RHEA:14409] +synonym: "2-aminoethanethiol:oxygen oxidoreductase activity" RELATED [EC:1.13.11.19] +synonym: "cysteamine oxygenase activity" RELATED [EC:1.13.11.19] +synonym: "cysteamine:oxygen oxidoreductase activity" RELATED [EC:1.13.11.19] +synonym: "persulfurase activity" RELATED [EC:1.13.11.19] +xref: EC:1.13.11.19 +xref: KEGG_REACTION:R02467 +xref: MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN +xref: Reactome:R-HSA-6814153 "ADO oxidises 2AET to HTAU" +xref: RHEA:14409 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047801 +name: L-cysteine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate." [RHEA:17441] +synonym: "cysteine aminotransferase activity" BROAD [] +synonym: "cysteine transaminase activity" EXACT [EC:2.6.1.3] +synonym: "L-cysteine:2-oxoglutarate aminotransferase activity" EXACT [] +xref: EC:2.6.1.3 +xref: MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-9012597 "GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu" +xref: RHEA:17441 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047802 +name: cysteine-conjugate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate." [EC:2.6.1.75, RHEA:13485] +synonym: "cysteine conjugate aminotransferase activity" RELATED [EC:2.6.1.75] +synonym: "cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)" RELATED [EC:2.6.1.75] +synonym: "S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.75] +xref: EC:2.6.1.75 +xref: KEGG_REACTION:R04338 +xref: MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN +xref: RHEA:13485 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047803 +name: cysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." [EC:4.4.1.10, MetaCyc:CYSTEINE-LYASE-RXN] +synonym: "cysteine (sulfite) lyase activity" RELATED [EC:4.4.1.10] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite)" RELATED [EC:4.4.1.10] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)" RELATED [EC:4.4.1.10] +xref: EC:4.4.1.10 +xref: MetaCyc:CYSTEINE-LYASE-RXN +xref: RHEA:20916 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047804 +name: cysteine-S-conjugate beta-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate." [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN] +synonym: "cysteine conjugate beta-lyase activity" RELATED [EC:4.4.1.13] +synonym: "cysteine-S-conjugate b-lyase activity" EXACT [] +synonym: "glutamine transaminase K/cysteine conjugate beta-lyase activity" RELATED [EC:4.4.1.13] +synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating) activity" RELATED [EC:4.4.1.13] +synonym: "L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.13] +xref: EC:4.4.1.13 +xref: MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN +xref: RHEA:18121 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047805 +name: cytidylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+)." [EC:4.6.1.6, RHEA:14737] +synonym: "3',5'-cyclic-CMP synthase activity" RELATED [EC:4.6.1.6] +synonym: "3'5'-cyclic-CMP synthase activity" RELATED [EC:4.6.1.6] +synonym: "CTP diphosphate-lyase (cyclizing)" RELATED [EC:4.6.1.6] +synonym: "CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)" RELATED [EC:4.6.1.6] +synonym: "cytidyl cyclase activity" RELATED [EC:4.6.1.6] +synonym: "cytidylyl cyclase activity" RELATED [EC:4.6.1.6] +xref: EC:4.6.1.6 +xref: KEGG_REACTION:R00574 +xref: MetaCyc:CYTIDYLATE-CYCLASE-RXN +xref: RHEA:14737 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0047806 +name: cytochrome-c3 hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3." [EC:1.12.2.1, MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN] +synonym: "cytochrome c3 reductase activity" RELATED [EC:1.12.2.1] +synonym: "cytochrome hydrogenase activity" BROAD [EC:1.12.2.1] +synonym: "H(2):ferricytochrome c3 oxidoreductase activity" RELATED [EC:1.12.2.1] +synonym: "H2:ferricytochrome c3 oxidoreductase activity" RELATED [EC:1.12.2.1] +synonym: "hydrogen:ferricytochrome-c3 oxidoreductase activity" RELATED [EC:1.12.2.1] +xref: EC:1.12.2.1 +xref: MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN +xref: RHEA:20625 +xref: UM-BBD_enzymeID:e0481 +is_a: GO:0016697 ! oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor + +[Term] +id: GO:0047807 +name: cytokinin 7-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [EC:2.4.1.118, MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "cytokinin 7-b-glucosyltransferase activity" EXACT [] +synonym: "cytokinin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118] +synonym: "UDP-glucose-zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118] +synonym: "UDP-glucose:zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118] +synonym: "UDPglucose:zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118] +synonym: "uridine diphosphoglucose-zeatin 7-glucosyltransferase activity" RELATED [EC:2.4.1.118] +xref: EC:2.4.1.118 +xref: KEGG_REACTION:R04071 +xref: MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:23272 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047808 +name: D(-)-tartrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.81, RHEA:18289] +synonym: "(S,S)-tartrate hydro-lyase (oxaloacetate-forming)" RELATED [EC:4.2.1.81] +synonym: "(S,S)-tartrate hydro-lyase activity" RELATED [EC:4.2.1.81] +synonym: "D-tartrate dehydratase activity" RELATED [EC:4.2.1.81] +xref: EC:4.2.1.81 +xref: KEGG_REACTION:R00340 +xref: MetaCyc:D--TARTRATE-DEHYDRATASE-RXN +xref: RHEA:18289 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047809 +name: D-2-hydroxy-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate." [EC:1.1.99.6, RHEA:15089] +synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.99.6] +synonym: "2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.99.6] +xref: EC:1.1.99.6 +xref: KEGG_REACTION:R00297 +xref: MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN +xref: RHEA:15089 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047810 +name: D-alanine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate." [EC:2.6.1.21, MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN] +synonym: "D-alanine aminotransferase activity" EXACT [] +synonym: "D-alanine transaminase activity" BROAD [EC:2.6.1.21] +synonym: "D-alanine-D-glutamate transaminase activity" RELATED [EC:2.6.1.21] +synonym: "D-amino acid aminotransferase activity" BROAD [EC:2.6.1.21] +synonym: "D-amino acid transaminase activity" BROAD [EC:2.6.1.21] +synonym: "D-amino-acid transaminase activity" BROAD [EC:2.6.1.21] +synonym: "D-aspartate aminotransferase activity" RELATED [EC:2.6.1.21] +synonym: "D-aspartate transaminase activity" RELATED [EC:2.6.1.21] +synonym: "D-aspartic aminotransferase activity" RELATED [EC:2.6.1.21] +xref: EC:2.6.1.21 +xref: MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN +xref: RHEA:15869 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047811 +name: D-alanine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+)." [EC:2.3.2.14, RHEA:23556] +synonym: "D-alanine g-glutamyltransferase activity" EXACT [] +synonym: "L-glutamine:D-alanine gamma-glutamyltransferase activity" RELATED [EC:2.3.2.14] +xref: EC:2.3.2.14 +xref: KEGG_REACTION:R01149 +xref: MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN +xref: RHEA:23556 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0047812 +name: D-amino-acid N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid." [EC:2.3.1.36, MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:D-amino-acid N-acetyltransferase activity" RELATED [EC:2.3.1.36] +synonym: "D-amino acid acetyltransferase activity" RELATED [EC:2.3.1.36] +synonym: "D-amino acid-alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.36] +xref: EC:2.3.1.36 +xref: MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN +xref: RHEA:20704 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047813 +name: D-arabinitol 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH." [EC:1.1.1.11, MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN] +xref: EC:1.1.1.11 +xref: MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN +xref: RHEA:17921 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047814 +name: D-arabinokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP." [EC:2.7.1.54, RHEA:24588] +synonym: "ATP:D-arabinose 5-phosphotransferase activity" RELATED [EC:2.7.1.54] +synonym: "D-arabinokinase (phosphorylating)" RELATED [EC:2.7.1.54] +xref: EC:2.7.1.54 +xref: KEGG_REACTION:R01573 +xref: MetaCyc:D-ARABINOKINASE-RXN +xref: RHEA:24588 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047815 +name: D-arabinonolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+)." [EC:3.1.1.30, RHEA:23108] +synonym: "D-arabinono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.30] +xref: EC:3.1.1.30 +xref: KEGG_REACTION:R02714 +xref: MetaCyc:D-ARABINONOLACTONASE-RXN +xref: RHEA:23108 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047816 +name: D-arabinose 1-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH." [EC:1.1.1.116, MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN] +synonym: "arabinose(fucose)dehydrogenase activity" RELATED [EC:1.1.1.116] +synonym: "D-arabinose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.116] +synonym: "NAD-pentose-dehydrogenase activity" RELATED [EC:1.1.1.116] +xref: EC:1.1.1.116 +xref: MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN +xref: RHEA:20457 +is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0047817 +name: D-arginase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea." [EC:3.5.3.10, RHEA:12901] +synonym: "D-arginine amidinohydrolase activity" RELATED [EC:3.5.3.10] +xref: EC:3.5.3.10 +xref: KEGG_REACTION:R02458 +xref: MetaCyc:D-ARGINASE-RXN +xref: RHEA:12901 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047818 +name: D-fuconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O." [EC:4.2.1.67, RHEA:12949] +synonym: "D-fuconate hydratase activity" EXACT [] +synonym: "D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)" RELATED [EC:4.2.1.67] +synonym: "D-fuconate hydro-lyase activity" RELATED [EC:4.2.1.67] +xref: EC:4.2.1.67 +xref: KEGG_REACTION:R03671 +xref: MetaCyc:D-FUCONATE-HYDRATASE-RXN +xref: RHEA:12949 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047819 +name: D-glutamate(D-aspartate) oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.15, MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN] +comment: For the individual reactions, see instead 'D-glutamate oxidase activity ;GO:0047821' and 'D-aspartate oxidase activity ; GO:0008445'. +synonym: "D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.15] +synonym: "D-glutamic-aspartic oxidase activity" RELATED [EC:1.4.3.15] +synonym: "D-monoaminodicarboxylic acid oxidase activity" RELATED [EC:1.4.3.15] +xref: EC:1.4.3.15 +xref: MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN +is_a: GO:0003884 ! D-amino-acid oxidase activity + +[Term] +id: GO:0047820 +name: D-glutamate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O." [EC:4.2.1.48, RHEA:22360] +synonym: "D-glutamate hydro-lyase (cyclizing)" RELATED [EC:4.2.1.48] +synonym: "D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)" RELATED [EC:4.2.1.48] +xref: EC:4.2.1.48 +xref: KEGG_REACTION:R01583 +xref: MetaCyc:D-GLUTAMATE-CYCLASE-RXN +xref: RHEA:22360 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047821 +name: D-glutamate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.7, MetaCyc:D-GLUTAMATE-OXIDASE-RXN] +synonym: "D-glutamate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.7] +synonym: "D-glutamic acid oxidase activity" RELATED [EC:1.4.3.7] +synonym: "D-glutamic oxidase activity" RELATED [EC:1.4.3.7] +xref: EC:1.4.3.7 +xref: KEGG_REACTION:R00279 +xref: MetaCyc:D-GLUTAMATE-OXIDASE-RXN +xref: RHEA:10028 +is_a: GO:0003884 ! D-amino-acid oxidase activity + +[Term] +id: GO:0047822 +name: hypotaurine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine." [RHEA:17385] +synonym: "hypotaurine:NAD+ oxidoreductase activity" RELATED [EC:1.8.1.3] +xref: EC:1.8.1.3 +xref: KEGG_REACTION:R01681 +xref: MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-1655453 "HTAUDH oxidises HTAU to TAU" +xref: RHEA:17385 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0047823 +name: D-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." [EC:2.3.2.1, MetaCyc:D-GLUTAMYLTRANSFERASE-RXN] +synonym: "D-gamma-glutamyl transpeptidase activity" RELATED [EC:2.3.2.1] +synonym: "D-glutamyl transpeptidase activity" RELATED [EC:2.3.2.1] +synonym: "glutamine:D-glutamyl-peptide 5-glutamyltransferase activity" RELATED [EC:2.3.2.1] +xref: EC:2.3.2.1 +xref: MetaCyc:D-GLUTAMYLTRANSFERASE-RXN +xref: RHEA:35623 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0047824 +name: D-iditol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH." [EC:1.1.1.15, MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN] +xref: EC:1.1.1.15 +xref: MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN +xref: RHEA:12725 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +is_a: GO:0031320 ! hexitol dehydrogenase activity + +[Term] +id: GO:0047825 +name: D-lactate-2-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate." [EC:3.1.6.17, RHEA:20337] +synonym: "(S)-2-O-sulfolactate 2-sulfohydrolase activity" RELATED [EC:3.1.6.17] +synonym: "D-lactate-2-sulphatase activity" EXACT [] +xref: EC:3.1.6.17 +xref: KEGG_REACTION:R01448 +xref: MetaCyc:D-LACTATE-2-SULFATASE-RXN +xref: RHEA:20337 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047826 +name: D-lysine 5,6-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate." [EC:5.4.3.4, RHEA:18241] +synonym: "adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity" RELATED [EC:5.4.3.4] +synonym: "D-2,6-diaminohexanoate 5,6-aminomutase activity" RELATED [EC:5.4.3.4] +synonym: "D-alpha-lysine mutase activity" RELATED [EC:5.4.3.4] +xref: EC:5.4.3.4 +xref: KEGG_REACTION:R02852 +xref: MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN +xref: RHEA:18241 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047827 +name: D-lysopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate." [EC:1.5.1.16, RHEA:17625] +synonym: "2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.16] +synonym: "D(+)-lysopine dehydrogenase activity" RELATED [EC:1.5.1.16] +synonym: "D-lysopine synthase activity" RELATED [EC:1.5.1.16] +synonym: "lysopine dehydrogenase activity" RELATED [EC:1.5.1.16] +synonym: "N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)" RELATED [EC:1.5.1.16] +xref: EC:1.5.1.16 +xref: KEGG_REACTION:R00452 +xref: MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN +xref: RHEA:17625 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047828 +name: D-lyxose ketol-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-lyxose = D-xylulose." [EC:5.3.1.15, RHEA:14201] +synonym: "D-lyxose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.15] +synonym: "D-lyxose isomerase activity" RELATED [EC:5.3.1.15] +xref: EC:5.3.1.15 +xref: KEGG_REACTION:R01898 +xref: MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN +xref: RHEA:14201 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0047829 +name: D-nopaline dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH." [EC:1.5.1.19, MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN] +synonym: "2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.19] +synonym: "D-nopaline synthase activity" RELATED [EC:1.5.1.19] +synonym: "N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.19] +synonym: "nopaline dehydrogenase activity" RELATED [EC:1.5.1.19] +synonym: "nopaline synthase activity" RELATED [EC:1.5.1.19] +synonym: "NOS activity" RELATED [EC:1.5.1.19] +xref: EC:1.5.1.19 +xref: MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN +xref: RHEA:19637 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047830 +name: D-octopine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH." [EC:1.5.1.11, MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN] +synonym: "2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.11] +synonym: "D-octopine synthase activity" RELATED [EC:1.5.1.11] +synonym: "N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)" RELATED [EC:1.5.1.11] +synonym: "octopine dehydrogenase activity" RELATED [EC:1.5.1.11] +synonym: "octopine:NAD oxidoreductase activity" RELATED [EC:1.5.1.11] +synonym: "ODH activity" RELATED [EC:1.5.1.11] +xref: EC:1.5.1.11 +xref: MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN +xref: RHEA:16285 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047831 +name: D-ornithine 4,5-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate." [EC:5.4.3.5, RHEA:14893] +synonym: "D-alpha-ornithine 5,4-aminomutase activity" RELATED [EC:5.4.3.5] +synonym: "D-ornithine aminomutase activity" RELATED [EC:5.4.3.5] +xref: EC:5.4.3.5 +xref: KEGG_REACTION:R02461 +xref: MetaCyc:ORNMUTST-RXN +xref: RHEA:14893 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0047832 +name: D-pinitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH." [EC:1.1.1.142, RHEA:20437] +synonym: "1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.142] +synonym: "5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.142] +xref: EC:1.1.1.142 +xref: KEGG_REACTION:R03498 +xref: MetaCyc:D-PINITOL-DEHYDROGENASE-RXN +xref: RHEA:20437 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047833 +name: D-sorbitol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor." [EC:1.1.99.21, MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN] +synonym: "D-sorbitol dehydrogenase activity" EXACT [] +synonym: "D-sorbitol:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.21] +synonym: "D-sorbitol:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.21] +xref: EC:1.1.99.21 +xref: MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN +xref: RHEA:21320 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047834 +name: D-threo-aldose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH." [EC:1.1.1.122, MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN] +synonym: "(2S,3R)-aldose dehydrogenase activity" RELATED [EC:1.1.1.122] +synonym: "D-threo-aldose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.122] +synonym: "dehydrogenase, L-fucose" RELATED [EC:1.1.1.122] +synonym: "L-fucose (D-arabinose) dehydrogenase activity" RELATED [EC:1.1.1.122] +synonym: "L-fucose dehydrogenase activity" RELATED [EC:1.1.1.122] +xref: EC:1.1.1.122 +xref: MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN +xref: RHEA:19645 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047835 +name: D-tryptophan N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.34, RHEA:10060] +synonym: "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.34] +synonym: "acetyl-CoA:D-tryptophan N-acetyltransferase activity" RELATED [EC:2.3.1.34] +synonym: "D-tryptophan acetyltransferase activity" RELATED [EC:2.3.1.34] +xref: EC:2.3.1.34 +xref: KEGG_REACTION:R02481 +xref: MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN +xref: RHEA:10060 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047836 +name: D-tryptophan N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+)." [EC:2.3.1.112, RHEA:23320] +synonym: "malonyl-CoA:D-tryptophan N-malonyltransferase activity" RELATED [EC:2.3.1.112] +xref: EC:2.3.1.112 +xref: KEGG_REACTION:R02482 +xref: MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN +xref: RHEA:23320 +is_a: GO:0050735 ! N-malonyltransferase activity + +[Term] +id: GO:0047837 +name: D-xylose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH." [EC:1.1.1.179, RHEA:22000] +synonym: "D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.179] +synonym: "D-xylose-NADP dehydrogenase activity" RELATED [EC:1.1.1.179] +synonym: "D-xylose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.179] +synonym: "D-xylose:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.179] +xref: EC:1.1.1.179 +xref: KEGG_REACTION:R01430 +xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN +xref: RHEA:22000 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047838 +name: D-xylose 1-dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." [EC:1.1.1.175, MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN] +synonym: "(NAD)-linked D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175] +synonym: "D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175] +synonym: "D-xylose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.175] +synonym: "NAD-D-xylose" RELATED [EC:1.1.1.175] +synonym: "NAD-D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175] +synonym: "NAD-linked D-xylose dehydrogenase activity" RELATED [EC:1.1.1.175] +xref: EC:1.1.1.175 +xref: MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN +xref: RHEA:13861 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047839 +name: dATP(dGTP)-DNA purinetransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA." [EC:2.6.99.1, MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN] +synonym: "dATP(dGTP)--DNA purine transferase activity" EXACT [] +synonym: "dATP(dGTP):depurinated-DNA purine transferase activity" RELATED [EC:2.6.99.1] +xref: EC:2.6.99.1 +xref: MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0047840 +name: dCTP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate." [RHEA:22636] +synonym: "dCTP nucleotidohydrolase activity" RELATED [EC:3.6.1.12] +synonym: "dCTP pyrophosphatase activity" EXACT [] +synonym: "dCTPase activity" RELATED [EC:3.6.1.12] +synonym: "deoxy-CTPase activity" RELATED [EC:3.6.1.12] +synonym: "deoxycytidine triphosphatase activity" RELATED [EC:3.6.1.12] +synonym: "deoxycytidine-triphosphatase activity" RELATED [EC:3.6.1.12] +xref: EC:3.6.1.12 +xref: MetaCyc:DCTP-PYROPHOSPHATASE-RXN +xref: Reactome:R-HSA-6786257 "DCTPP1 hydrolyses 5idCTP" +xref: RHEA:22636 +is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity + +[Term] +id: GO:0047841 +name: dehydrogluconokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.13, RHEA:10788] +synonym: "2-ketogluconate kinase activity" RELATED [EC:2.7.1.13] +synonym: "2-ketogluconokinase activity" RELATED [EC:2.7.1.13] +synonym: "ATP:2-dehydro-D-gluconate 6-phosphotransferase activity" RELATED [EC:2.7.1.13] +synonym: "dehydogluconokinase activity" EXACT [] +synonym: "ketogluconokinase (phosphorylating)" RELATED [EC:2.7.1.13] +synonym: "ketogluconokinase activity" RELATED [EC:2.7.1.13] +xref: EC:2.7.1.13 +xref: KEGG_REACTION:R02658 +xref: MetaCyc:DEHYDOGLUCONOKINASE-RXN +xref: RHEA:10788 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047842 +name: dehydro-L-gulonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2)." [EC:4.1.1.34, RHEA:11084] +synonym: "3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)" RELATED [EC:4.1.1.34] +synonym: "3-dehydro-L-gulonate carboxy-lyase activity" RELATED [EC:4.1.1.34] +synonym: "3-keto-L-gulonate decarboxylase activity" RELATED [EC:4.1.1.34] +synonym: "keto-L-gulonate decarboxylase activity" RELATED [EC:4.1.1.34] +xref: EC:4.1.1.34 +xref: KEGG_REACTION:R01905 +xref: MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-5662473 "KGPDC decarboxylates 3-dehydro-L-gulonate to L-xylulose" +xref: RHEA:11084 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047843 +name: dehydrogluconate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2)." [EC:1.1.99.4, RHEA:12368] +synonym: "2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity" RELATED [EC:1.1.99.4] +synonym: "2-keto-D-gluconate dehydrogenase activity" RELATED [EC:1.1.99.4] +synonym: "2-oxogluconate dehydrogenase activity" RELATED [EC:1.1.99.4] +synonym: "alpha-ketogluconate dehydrogenase activity" RELATED [EC:1.1.99.4] +synonym: "ketogluconate dehydrogenase activity" RELATED [EC:1.1.99.4] +xref: EC:1.1.99.4 +xref: KEGG_REACTION:R07153 +xref: MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN +xref: RHEA:12368 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047844 +name: deoxycytidine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3." [EC:3.5.4.14, MetaCyc:DEOXYCYTIDINE-DEAMINASE-RXN] +synonym: "deoxycytidine aminohydrolase activity" RELATED [EC:3.5.4.14] +xref: EC:3.5.4.14 +xref: MetaCyc:CYTIDEAM-RXN +xref: RHEA:13433 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047845 +name: deoxylimonate A-ring-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+)." [EC:3.1.1.46, RHEA:14997] +synonym: "deoxylimonate A-ring-lactonohydrolase activity" RELATED [EC:3.1.1.46] +xref: EC:3.1.1.46 +xref: KEGG_REACTION:R03803 +xref: MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN +xref: RHEA:14997 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047846 +name: deoxynucleotide 3'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate." [EC:3.1.3.34, MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN] +synonym: "3'-deoxynucleotidase activity" RELATED [EC:3.1.3.34] +synonym: "3'-deoxyribonucleotidase activity" RELATED [EC:3.1.3.34] +synonym: "deoxyribonucleotide 3'-phosphohydrolase activity" RELATED [EC:3.1.3.34] +xref: EC:3.1.3.34 +xref: MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN +xref: RHEA:10092 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047847 +name: deoxyuridine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate." [EC:2.4.2.23, MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN] +synonym: "2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.23] +synonym: "deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.23] +synonym: "deoxyuridine:phosphate deoxy-D-ribosyltransferase activity" RELATED [EC:2.4.2.23] +xref: EC:2.4.2.23 +xref: MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN +xref: RHEA:22824 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047848 +name: dephospho-[reductase kinase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]." [EC:2.7.11.3, MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN] +synonym: "AMP-activated kinase activity" RELATED [EC:2.7.11.3] +synonym: "AMP-activated protein kinase kinase activity" RELATED [EC:2.7.11.3] +synonym: "ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity" RELATED [EC:2.7.11.3] +synonym: "dephospho-reductase kinase kinase activity" RELATED [EC:2.7.11.3] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity" RELATED [EC:2.7.11.3] +synonym: "hydroxymethylglutaryl coenzyme A reductase kinase kinase activity" RELATED [EC:2.7.11.3] +synonym: "reductase kinase activity" BROAD [EC:2.7.11.3] +synonym: "reductase kinase kinase activity" RELATED [EC:2.7.11.3] +synonym: "STK30" RELATED [EC:2.7.11.3] +xref: EC:2.7.11.3 +xref: MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0047849 +name: dextransucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1)." [EC:2.4.1.5, MetaCyc:DEXTRANSUCRASE-RXN] +synonym: "CEP" RELATED [EC:2.4.1.5] +synonym: "SGE" RELATED [EC:2.4.1.5] +synonym: "sucrose 6-glucosyltransferase activity" RELATED [EC:2.4.1.5] +synonym: "sucrose-1,6-alpha-glucan glucosyltransferase activity" RELATED [EC:2.4.1.5] +synonym: "sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.5] +xref: EC:2.4.1.5 +xref: MetaCyc:DEXTRANSUCRASE-RXN +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0047850 +name: diaminopimelate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+)." [EC:1.4.1.16, RHEA:13561] +synonym: "meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.16] +synonym: "meso-alpha,epsilon-diaminopimelate dehydrogenase activity" RELATED [EC:1.4.1.16] +synonym: "meso-diaminopimelate D-dehydrogenase activity" RELATED [EC:1.4.1.16] +synonym: "meso-diaminopimelate dehydrogenase activity" RELATED [EC:1.4.1.16] +xref: EC:1.4.1.16 +xref: KEGG_REACTION:R02755 +xref: MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN +xref: RHEA:13561 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047851 +name: dicarboxylate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA." [EC:6.2.1.23, MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN] +synonym: "carboxylyl-CoA synthetase activity" RELATED [EC:6.2.1.23] +synonym: "omega-dicarboxylate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.23] +xref: EC:6.2.1.23 +xref: MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN +xref: RHEA:14289 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047852 +name: diferric-transferrin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH." [RHEA:13841] +synonym: "diferric transferrin reductase activity" RELATED [EC:1.16.1.2] +synonym: "NADH diferric transferrin reductase activity" RELATED [EC:1.16.1.2] +synonym: "transferrin reductase activity" RELATED [EC:1.16.1.2] +synonym: "transferrin[Fe(II)]2:NAD+ oxidoreductase activity" RELATED [EC:1.16.1.2] +xref: EC:1.16.1.2 +xref: MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN +xref: RHEA:13841 +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0047853 +name: difructose-anhydride synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose." [EC:3.2.1.134, MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN] +synonym: "bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity" RELATED [EC:3.2.1.134] +synonym: "inulobiose hydrolase activity" RELATED [EC:3.2.1.134] +xref: EC:3.2.1.134 +xref: MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN +xref: RHEA:15041 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047854 +name: diguanidinobutanase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea." [EC:3.5.3.20, RHEA:13597] +synonym: "1,4-diguanidinobutane amidinohydrolase activity" RELATED [EC:3.5.3.20] +xref: EC:3.5.3.20 +xref: KEGG_REACTION:R01418 +xref: MetaCyc:DIGUANIDINOBUTANASE-RXN +xref: RHEA:13597 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047855 +name: dihydrobunolol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH." [EC:1.1.1.160, RHEA:15925] +synonym: "(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.160] +synonym: "bunolol reductase activity" RELATED [EC:1.1.1.160] +xref: EC:1.1.1.160 +xref: KEGG_REACTION:R04623 +xref: MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN +xref: RHEA:15925 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047856 +name: dihydrocoumarin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+)." [EC:3.1.1.35, RHEA:10360] +synonym: "dihydrocoumarin lactonohydrolase activity" RELATED [EC:3.1.1.35] +synonym: "dihydrocoumarin lipase activity" EXACT [] +xref: EC:3.1.1.35 +xref: KEGG_REACTION:R03692 +xref: MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN +xref: RHEA:10360 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047857 +name: dihydrouracil oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil." [EC:1.3.3.7, RHEA:12384] +synonym: "5,6-dihydrouracil:oxygen oxidoreductase activity" RELATED [EC:1.3.3.7] +xref: EC:1.3.3.7 +xref: KEGG_REACTION:R00975 +xref: MetaCyc:DIHYDROURACIL-OXIDASE-RXN +xref: RHEA:12384 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0047858 +name: dihydroxyfumarate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.54, RHEA:13845] +synonym: "dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming)" RELATED [EC:4.1.1.54] +synonym: "dihydroxyfumarate carboxy-lyase activity" RELATED [EC:4.1.1.54] +xref: EC:4.1.1.54 +xref: KEGG_REACTION:R03127 +xref: MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN +xref: RHEA:13845 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047859 +name: obsolete dihydroxyphenylalanine ammonia-lyase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine = trans-caffeate + NH3." [EC:4.3.1.11, MetaCyc:DIHYDROXYPHENYLALANINE-AMMONIA-LYASE-RXN] +comment: This term was made obsolete because the corresponding EC reaction (EC:4.3.1.11) has been deleted from the EC. +synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase (trans-caffeate-forming)" RELATED [EC:4.3.1.11] +synonym: "3,4-dihydroxy-L-phenylalanine ammonia-lyase activity" RELATED [EC:4.3.1.11] +synonym: "beta-(3,4-dihydroxyphenyl)-L-alanine (DOPA) ammonia-lyase activity" RELATED [EC:4.3.1.11] +synonym: "dihydroxyphenylalanine ammonia-lyase activity" EXACT [] +xref: EC:4.3.1.11 +is_obsolete: true + +[Term] +id: GO:0047860 +name: diiodophenylpyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH." [EC:1.1.1.96, RHEA:20293] +synonym: "2-oxo acid reductase activity" RELATED [EC:1.1.1.96] +synonym: "3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.96] +synonym: "aromatic alpha-keto acid" RELATED [EC:1.1.1.96] +synonym: "KAR" RELATED [EC:1.1.1.96] +xref: EC:1.1.1.96 +xref: KEGG_REACTION:R03431 +xref: MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN +xref: RHEA:20293 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047861 +name: diiodotyrosine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate." [EC:2.6.1.24, RHEA:19781] +synonym: "3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.24] +synonym: "diiodotyrosine aminotransferase activity" EXACT [] +synonym: "halogenated tyrosine aminotransferase activity" RELATED [EC:2.6.1.24] +synonym: "halogenated tyrosine transaminase activity" RELATED [EC:2.6.1.24] +xref: EC:2.6.1.24 +xref: KEGG_REACTION:R03207 +xref: MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN +xref: RHEA:19781 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047862 +name: diisopropyl-fluorophosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride." [EC:3.1.8.2, RHEA:24100] +synonym: "DFPase activity" RELATED [EC:3.1.8.2] +synonym: "dialkylfluorophosphatase activity" RELATED [EC:3.1.8.2] +synonym: "diisopropyl phosphorofluoridate hydrolase activity" RELATED [EC:3.1.8.2] +synonym: "diisopropyl-fluorophosphate fluorohydrolase activity" RELATED [EC:3.1.8.2] +synonym: "diisopropylfluorophosphonate dehalogenase activity" RELATED [EC:3.1.8.2] +synonym: "diisopropylphosphofluoridase activity" RELATED [EC:3.1.8.2] +synonym: "isopropylphosphorofluoridase activity" RELATED [EC:3.1.8.2] +synonym: "OPA anhydrase activity" RELATED [EC:3.1.8.2] +synonym: "OPAA activity" RELATED [EC:3.1.8.2] +synonym: "organophosphate acid anhydrase activity" RELATED [EC:3.1.8.2] +synonym: "organophosphorus acid anhydrolase activity" RELATED [EC:3.1.8.2] +synonym: "somanase activity" RELATED [EC:3.1.8.2] +synonym: "tabunase activity" RELATED [EC:3.1.8.2] +xref: EC:3.1.8.2 +xref: KEGG_REACTION:R01533 +xref: MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN +xref: RHEA:24100 +is_a: GO:0016795 ! phosphoric triester hydrolase activity + +[Term] +id: GO:0047863 +name: dimethylallylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate." [EC:2.5.1.28, RHEA:11328] +synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity" RELATED [EC:2.5.1.28] +synonym: "neryl-diphosphate synthase activity" RELATED [EC:2.5.1.28] +xref: EC:2.5.1.28 +xref: KEGG_REACTION:R01659 +xref: MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN +xref: RHEA:11328 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0047864 +name: dimethylaniline-N-oxide aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde." [EC:4.1.2.24, RHEA:19321] +synonym: "microsomal N-oxide dealkylase activity" RELATED [EC:4.1.2.24] +synonym: "microsomal oxidase II" RELATED [EC:4.1.2.24] +synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)" RELATED [EC:4.1.2.24] +synonym: "N,N-dimethylaniline-N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.24] +xref: EC:4.1.2.24 +xref: KEGG_REACTION:R03345 +xref: MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN +xref: RHEA:19321 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047865 +name: dimethylglycine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.4, RHEA:52856] +comment: Note that this was EC:1.5.99.2. +synonym: "N,N-dimethylglycine oxidase activity" RELATED [EC:1.5.8.4] +synonym: "N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.8.4] +synonym: "N,N-dimethylglycine:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.8.4] +xref: EC:1.5.8.4 +xref: KEGG_REACTION:R01565 +xref: MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-6797653 "DMGDH:FAD oxidatively demethylates DMGLY to SARC" +xref: RHEA:52856 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor + +[Term] +id: GO:0047866 +name: dimethylglycine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine." [EC:1.5.3.10, RHEA:17077] +synonym: "N,N-dimethylglycine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.10] +xref: EC:1.5.3.10 +xref: KEGG_REACTION:R01564 +xref: MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN +xref: RHEA:17077 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0047867 +name: dimethylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH." [EC:1.1.1.84, RHEA:13321] +synonym: "(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)" RELATED [EC:1.1.1.84] +synonym: "beta,beta-dimethylmalate dehydrogenase activity" RELATED [EC:1.1.1.84] +xref: EC:1.1.1.84 +xref: KEGG_REACTION:R01211 +xref: MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN +xref: RHEA:13321 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047868 +name: dimethylmaleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O." [EC:4.2.1.85, RHEA:20253] +synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)" RELATED [EC:4.2.1.85] +synonym: "(2R,3S)-2,3-dimethylmalate hydro-lyase activity" RELATED [EC:4.2.1.85] +xref: EC:4.2.1.85 +xref: KEGG_REACTION:R03069 +xref: MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN +xref: RHEA:20253 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047869 +name: dimethylpropiothetin dethiomethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+)." [EC:4.4.1.3, RHEA:19965] +synonym: "desulfhydrase activity" RELATED [EC:4.4.1.3] +synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming)" RELATED [EC:4.4.1.3] +synonym: "S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity" RELATED [EC:4.4.1.3] +xref: EC:4.4.1.3 +xref: KEGG_REACTION:R02574 +xref: MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN +xref: RHEA:19965 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047870 +name: discadenine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+)." [EC:2.5.1.24, RHEA:19581] +synonym: "discadenine synthetase activity" RELATED [EC:2.5.1.24] +synonym: "S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity" RELATED [EC:2.5.1.24] +synonym: "S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas" RELATED [EC:2.5.1.24] +xref: EC:2.5.1.24 +xref: KEGG_REACTION:R03726 +xref: MetaCyc:DISCADENINE-SYNTHASE-RXN +xref: RHEA:19581 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0047871 +name: disulfoglucosamine-6-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate." [EC:3.1.6.11, RHEA:15517] +synonym: "6,N-disulfoglucosamine 6-O-sulfohydrolase activity" RELATED [EC:3.1.6.11] +synonym: "disulphoglucosamine-6-sulphatase activity" EXACT [] +synonym: "N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity" RELATED [EC:3.1.6.11] +synonym: "N-sulfoglucosamine-6-sulfatase activity" RELATED [EC:3.1.6.11] +xref: EC:3.1.6.11 +xref: KEGG_REACTION:R03216 +xref: MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN +xref: RHEA:15517 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047872 +name: dolichol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate." [EC:2.3.1.123, MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:dolichol acyltransferase activity" RELATED [EC:2.3.1.123] +synonym: "palmitoyl-CoA:dolichol O-palmitoyltransferase activity" RELATED [EC:2.3.1.123] +xref: EC:2.3.1.123 +xref: MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN +xref: RHEA:16685 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047873 +name: dolichyl-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate." [EC:3.1.3.51, MetaCyc:DOLICHYL-PHOSPHATASE-RXN] +synonym: "Dol-P phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "Dol-P-P phosphohydrolase activity" EXACT [] +synonym: "dolichol monophosphatase activity" RELATED [EC:3.1.3.51] +synonym: "dolichol phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "dolichol phosphate phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "dolichyl monophosphate phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "dolichyl phosphate phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "dolichyl pyrophosphate phosphatase activity" EXACT [] +synonym: "dolichyl-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.51] +synonym: "polyisoprenyl phosphate phosphatase activity" RELATED [EC:3.1.3.51] +synonym: "polyprenylphosphate phosphatase activity" RELATED [EC:3.1.3.51] +xref: EC:3.1.3.51 +xref: MetaCyc:DOLICHYL-PHOSPHATASE-RXN +xref: RHEA:13797 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047874 +name: dolichyldiphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate." [EC:3.6.1.43, MetaCyc:DOLICHYLDIPHOSPHATASE-RXN] +synonym: "dolichol diphosphatase activity" RELATED [EC:3.6.1.43] +synonym: "dolichyl diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.43] +synonym: "dolichyl pyrophosphatase activity" RELATED [EC:3.6.1.43] +synonym: "dolichyl-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.43] +xref: EC:3.6.1.43 +xref: MetaCyc:DOLICHYLDIPHOSPHATASE-RXN +xref: Reactome:R-HSA-446200 "DOLPP1 dephosphorylates DOLDP to DOLP" +xref: RHEA:14385 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0047875 +name: ecdysone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2)." [EC:1.1.3.16, RHEA:11796] +synonym: "beta-ecdysone oxidase activity" RELATED [EC:1.1.3.16] +synonym: "ecdysone:oxygen 3-oxidoreductase activity" RELATED [EC:1.1.3.16] +xref: EC:1.1.3.16 +xref: KEGG_REACTION:R02373 +xref: MetaCyc:ECDYSONE-OXIDASE-RXN +xref: RHEA:11796 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047876 +name: endoglycosylceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose." [EC:3.2.1.123, MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN] +synonym: "EGCase activity" RELATED [EC:3.2.1.123] +synonym: "endo-glucosylceramidase activity" RELATED [EC:3.2.1.123] +synonym: "endoglycoceramidase activity" RELATED [EC:3.2.1.123] +synonym: "glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity" RELATED [EC:3.2.1.123] +synonym: "oligoglycosylglucosylceramide glycohydrolase activity" RELATED [EC:3.2.1.123] +xref: EC:3.2.1.123 +xref: MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN +xref: RHEA:22288 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047877 +name: ephedrine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH." [EC:1.5.1.18, RHEA:16289] +synonym: "(-)-ephedrine:NAD+ 2-oxidoreductase activity" RELATED [EC:1.5.1.18] +xref: EC:1.5.1.18 +xref: KEGG_REACTION:R03614 +xref: MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN +xref: RHEA:16289 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047878 +name: erythritol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.27, RHEA:20708] +synonym: "ATP:erythritol 4-phosphotransferase activity" RELATED [EC:2.7.1.27] +synonym: "erythritol kinase (phosphorylating)" RELATED [EC:2.7.1.27] +xref: EC:2.7.1.27 +xref: KEGG_REACTION:R02430 +xref: MetaCyc:ERYTHRITOL-KINASE-RXN +xref: RHEA:20708 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047879 +name: erythronolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B." [EC:2.3.1.94, MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN] +synonym: "erythronolide condensing enzyme activity" RELATED [EC:2.3.1.94] +synonym: "malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.94] +xref: EC:2.3.1.94 +xref: MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN +xref: RHEA:23068 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047880 +name: erythrulose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH." [EC:1.1.1.162, RHEA:18005] +synonym: "D-erythrulose reductase activity" RELATED [EC:1.1.1.162] +synonym: "erythritol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.162] +xref: EC:1.1.1.162 +xref: KEGG_REACTION:R08573 +xref: MetaCyc:ERYTHRULOSE-REDUCTASE-RXN +xref: RHEA:18005 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047881 +name: estradiol 17-alpha-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+." [EC:1.1.1.148, MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN] +synonym: "17alpha-estradiol dehydrogenase activity" RELATED [EC:1.1.1.148] +synonym: "17alpha-hydroxy steroid dehydrogenase activity" RELATED [EC:1.1.1.148] +synonym: "17alpha-hydroxy steroid oxidoreductase activity" RELATED [EC:1.1.1.148] +synonym: "17alpha-hydroxysteroid oxidoreductase activity" RELATED [EC:1.1.1.148] +synonym: "17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity" RELATED [EC:1.1.1.148] +synonym: "estradiol 17a-dehydrogenase activity" EXACT [] +synonym: "estradiol 17alpha-dehydrogenase activity" RELATED [EC:1.1.1.148] +synonym: "estradiol 17alpha-oxidoreductase activity" RELATED [EC:1.1.1.148] +xref: EC:1.1.1.148 +xref: MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047882 +name: estradiol 6-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O." [EC:1.14.99.11, RHEA:19137] +synonym: "estradiol 6-beta-hydroxylase activity" RELATED [EC:1.14.99.11] +synonym: "estradiol 6b-hydroxylase activity" EXACT [] +synonym: "estradiol 6b-monooxygenase activity" EXACT [] +synonym: "estradiol 6beta-hydroxylase activity" RELATED [EC:1.14.99.11] +synonym: "estradiol 6beta-monooxygenase activity" RELATED [EC:1.14.99.11] +synonym: "estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)" RELATED [EC:1.14.99.11] +xref: EC:1.14.99.11 +xref: KEGG_REACTION:R03086 +xref: MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN +xref: RHEA:19137 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0047883 +name: ethanolamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2." [EC:1.4.3.8, MetaCyc:ETHANOLAMINE-OXIDASE-RXN] +synonym: "ethanolamine:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.8] +xref: EC:1.4.3.8 +xref: MetaCyc:ETHANOLAMINE-OXIDASE-RXN +xref: RHEA:18581 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0047884 +name: FAD diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: FAD + H2O = AMP + FMN." [EC:3.6.1.18, MetaCyc:FAD-PYROPHOSPHATASE-RXN] +synonym: "FAD nucleotidohydrolase activity" RELATED [EC:3.6.1.18] +synonym: "FAD pyrophosphatase activity" EXACT [] +synonym: "FAD pyrophosphohydrolase activity" EXACT [GOC:tb] +synonym: "flavin adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18] +synonym: "flavine adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18] +synonym: "riboflavin adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18] +synonym: "riboflavine adenine dinucleotide pyrophosphatase activity" RELATED [EC:3.6.1.18] +xref: EC:3.6.1.18 +xref: MetaCyc:FAD-PYROPHOSPHATASE-RXN +xref: RHEA:13889 +is_a: GO:0004551 ! nucleotide diphosphatase activity + +[Term] +id: GO:0047885 +name: farnesol 2-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol." [EC:5.2.1.9, RHEA:13401] +synonym: "2-trans,6-trans-farnesol 2-cis-trans-isomerase activity" RELATED [EC:5.2.1.9] +synonym: "farnesol isomerase activity" RELATED [EC:5.2.1.9] +xref: EC:5.2.1.9 +xref: KEGG_REACTION:R03265 +xref: MetaCyc:FARNESOL-2-ISOMERASE-RXN +xref: RHEA:13401 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047886 +name: farnesol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH." [EC:1.1.1.216, RHEA:14697] +synonym: "2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.216] +synonym: "farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.216] +synonym: "NADP-farnesol dehydrogenase activity" RELATED [EC:1.1.1.216] +xref: EC:1.1.1.216 +xref: KEGG_REACTION:R03264 +xref: MetaCyc:FARNESOL-DEHYDROGENASE-RXN +xref: RHEA:14697 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047887 +name: farnesyl diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP." [RHEA:21544] +synonym: "ATP:farnesyl-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.18] +synonym: "farnesyl pyrophosphate kinase activity" RELATED [EC:2.7.4.18] +synonym: "farnesyl-diphosphate kinase activity" EXACT [] +xref: EC:2.7.4.18 +xref: KEGG_REACTION:R02303 +xref: MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN +xref: RHEA:21544 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0047888 +name: fatty acid peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal." [EC:1.11.1.3, RHEA:23960] +synonym: "fatty-acid peroxidase activity" EXACT [] +synonym: "hexadecanoate:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.3] +synonym: "long chain fatty acid peroxidase activity" RELATED [EC:1.11.1.3] +xref: EC:1.11.1.3 +xref: KEGG_REACTION:R01703 +xref: MetaCyc:FATTY-ACID-PEROXIDASE-RXN +xref: RHEA:23960 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0047889 +name: ferredoxin-nitrate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin." [EC:1.7.7.2, MetaCyc:FERREDOXIN--NITRATE-REDUCTASE-RXN] +synonym: "assimilatory ferredoxin-nitrate reductase activity" RELATED [EC:1.7.7.2] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.7.2] +synonym: "nitrate (ferredoxin) reductase activity" RELATED [EC:1.7.7.2] +synonym: "nitrite:ferredoxin oxidoreductase activity" RELATED [EC:1.7.7.2] +xref: EC:1.7.7.2 +xref: MetaCyc:1.7.7.2-RXN +xref: RHEA:21828 +is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0047890 +name: flavanone 4-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH." [EC:1.1.1.234, MetaCyc:FLAVANONE-4-REDUCTASE-RXN] +synonym: "(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity" RELATED [EC:1.1.1.234] +synonym: "flavonone 4-reductase activity" EXACT [] +xref: EC:1.1.1.234 +xref: MetaCyc:FLAVANONE-4-REDUCTASE-RXN +xref: RHEA:11228 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047891 +name: flavone 7-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone." [EC:2.4.1.81, MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "flavone 7-O-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-apigenin beta-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "UDP-glucose-luteolin beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "UDPglucose-apigenin beta-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "UDPglucose-luteolin beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.81] +synonym: "uridine diphosphoglucose-luteolin glucosyltransferase activity" RELATED [EC:2.4.1.81] +xref: EC:2.4.1.81 +xref: MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:19577 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047892 +name: flavone apiosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone." [EC:2.4.2.25, MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN] +synonym: "UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity" RELATED [EC:2.4.2.25] +synonym: "UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity" RELATED [EC:2.4.2.25] +synonym: "uridine diphosphoapiose-flavone apiosyltransferase activity" RELATED [EC:2.4.2.25] +xref: EC:2.4.2.25 +xref: MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN +xref: RHEA:19153 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047893 +name: flavonol 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside." [EC:2.4.1.91, MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN] +synonym: "GTI" RELATED [EC:2.4.1.91] +synonym: "UDP-glucose flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91] +synonym: "UDP-glucose:flavonol 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.91] +synonym: "UDP-glucose:flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91] +synonym: "UDPG:flavonoid-3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91] +synonym: "UDPglucose:flavonol 3-O-D-glucosyltransferase activity" RELATED [EC:2.4.1.91] +synonym: "uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.91] +xref: EC:2.4.1.91 +xref: MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:22300 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047894 +name: flavonol 3-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13453] +subset: goslim_chembl +synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25] +synonym: "flavonol 3-sulphotransferase activity" EXACT [] +xref: EC:2.8.2.25 +xref: KEGG_REACTION:R02159 +xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN +xref: RHEA:13453 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0047895 +name: formaldehyde dismutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate." [EC:1.2.98.1, MetaCyc:FORMALDEHYDE-DISMUTASE-RXN] +synonym: "aldehyde dismutase activity" RELATED [EC:1.2.98.1] +synonym: "cannizzanase activity" RELATED [EC:1.2.98.1] +synonym: "formaldehyde:formaldehyde oxidoreductase activity" RELATED [EC:1.2.98.1] +synonym: "nicotinoprotein aldehyde dismutase" RELATED [EC:1.2.98.1] +xref: EC:1.2.98.1 +xref: MetaCyc:FORMALDEHYDE-DISMUTASE-RXN +xref: RHEA:19221 +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0047896 +name: formaldehyde transketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone." [EC:2.2.1.3, MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN] +synonym: "D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity" RELATED [EC:2.2.1.3] +synonym: "DHAS activity" RELATED [EC:2.2.1.3] +synonym: "dihydroxyacetone synthase activity" RELATED [EC:2.2.1.3] +synonym: "glycerone synthase activity" RELATED [EC:2.2.1.3] +xref: EC:2.2.1.3 +xref: MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN +xref: RHEA:24264 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0047897 +name: formate-dihydrofolate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate." [EC:6.3.4.17, RHEA:24328] +synonym: "dihydrofolate formyltransferase activity" RELATED [EC:6.3.4.17] +synonym: "formate:dihydrofolate ligase (ADP-forming)" RELATED [EC:6.3.4.17] +synonym: "formyl dihydrofolate synthase activity" RELATED [EC:6.3.4.17] +xref: EC:6.3.4.17 +xref: KEGG_REACTION:R02238 +xref: MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN +xref: RHEA:24328 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047898 +name: formate dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1." [EC:1.2.2.1, MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN] +synonym: "formate:cytochrome b1 oxidoreductase activity" RELATED [EC:1.2.2.1] +synonym: "formate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.1] +xref: EC:1.2.2.1 +xref: MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:21520 +is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor + +[Term] +id: GO:0047899 +name: formate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH." [EC:1.17.1.10, RHEA:12000] +synonym: "formate:NADP+ oxidoreductase activity" RELATED [EC:1.17.1.10] +synonym: "NADP-dependent formate dehydrogenase activity" RELATED [EC:1.17.1.10] +xref: EC:1.17.1.10 +xref: KEGG_REACTION:R00134 +xref: MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:12000 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047900 +name: formate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+)." [EC:2.7.2.6, RHEA:16009] +synonym: "ATP:formate phosphotransferase activity" RELATED [EC:2.7.2.6] +xref: EC:2.7.2.6 +xref: KEGG_REACTION:R00518 +xref: MetaCyc:FORMATE-KINASE-RXN +xref: RHEA:16009 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0047901 +name: formyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+)." [EC:3.1.2.10, RHEA:19741] +synonym: "formyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.10] +xref: EC:3.1.2.10 +xref: KEGG_REACTION:R00521 +xref: MetaCyc:FORMYL-COA-HYDROLASE-RXN +xref: RHEA:19741 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047902 +name: formylaspartate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate." [EC:3.5.1.8, MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN] +synonym: "formylaspartic formylase (formylase I, formylase II)" RELATED [EC:3.5.1.8] +synonym: "N-formyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.8] +xref: EC:3.5.1.8 +xref: MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN +xref: RHEA:22040 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047903 +name: fructose 5-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH." [EC:1.1.1.124, MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN] +synonym: "5-keto-D-fructose reductase (NADP+)" RELATED [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP(+)) activity" RELATED [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP)" RELATED [EC:1.1.1.124] +synonym: "5-ketofructose reductase (NADP+) activity" RELATED [EC:1.1.1.124] +synonym: "D-(-)fructose:(NADP+) 5-oxidoreductase activity" RELATED [EC:1.1.1.124] +synonym: "D-fructose:NADP+ 5-oxidoreductase activity" RELATED [EC:1.1.1.124] +synonym: "fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.124] +xref: EC:1.1.1.124 +xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN +xref: RHEA:14069 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047904 +name: fructose 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.11, RHEA:22304] +synonym: "D-fructose dehydrogenase activity" RELATED [EC:1.1.99.11] +synonym: "D-fructose:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.11] +synonym: "D-fructose:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.11] +synonym: "fructose 5-dehydrogenase (acceptor)" RELATED [EC:1.1.99.11] +xref: EC:1.1.99.11 +xref: KEGG_REACTION:R00873 +xref: MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN +xref: RHEA:22304 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047905 +name: fructose-6-phosphate phosphoketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O." [EC:4.1.2.22, MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN] +synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" RELATED [EC:4.1.2.22] +synonym: "D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity" RELATED [EC:4.1.2.22] +xref: EC:4.1.2.22 +xref: MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN +xref: RHEA:12196 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047906 +name: fucosterol-epoxide lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol." [EC:4.1.2.33, RHEA:10884] +synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming)" RELATED [EC:4.1.2.33] +synonym: "(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity" RELATED [EC:4.1.2.33] +xref: EC:4.1.2.33 +xref: KEGG_REACTION:R03723 +xref: MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN +xref: RHEA:10884 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0047907 +name: furylfuramide isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide." [EC:5.2.1.6, RHEA:21848] +synonym: "2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity" RELATED [EC:5.2.1.6] +xref: EC:5.2.1.6 +xref: KEGG_REACTION:R04538 +xref: MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN +xref: RHEA:21848 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0047908 +name: fusarinine-C ornithinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol." [EC:3.1.1.48, MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN] +synonym: "5-N-acyl-L-ornithine-ester hydrolase activity" RELATED [EC:3.1.1.48] +synonym: "N5-acyl-L-ornithine-ester hydrolase activity" RELATED [EC:3.1.1.48] +synonym: "ornithine esterase activity" RELATED [EC:3.1.1.48] +xref: EC:3.1.1.48 +xref: MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN +xref: RHEA:20165 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047909 +name: galactolipid O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol." [EC:2.3.1.134, MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN] +synonym: "galactolipid:galactolipid acyltransferase activity" RELATED [EC:2.3.1.134] +synonym: "mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity" RELATED [EC:2.3.1.134] +xref: EC:2.3.1.134 +xref: MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0047910 +name: galactose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH." [EC:1.1.1.120, MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN] +synonym: "D-galactose dehydrogenase (NADP+)" RELATED [EC:1.1.1.120] +synonym: "D-galactose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.120] +xref: EC:1.1.1.120 +xref: MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN +xref: RHEA:18625 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047911 +name: galacturan 1,4-alpha-galacturonidase activity +namespace: molecular_function +def: "Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate." [EC:3.2.1.67, MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN] +synonym: "exo-D-galacturonanase activity" RELATED [EC:3.2.1.67] +synonym: "exo-D-galacturonase activity" EXACT [] +synonym: "exo-polygalacturonase activity" EXACT [] +synonym: "exopoly-D-galacturonase activity" EXACT [] +synonym: "exopolygalacturonase activity" RELATED [EC:3.2.1.67] +synonym: "galacturan alpha-1,4-galacturonidase activity" EXACT [] +synonym: "poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity" RELATED [EC:3.2.1.67] +synonym: "poly(galacturonate) hydrolase activity" RELATED [EC:3.2.1.67] +xref: EC:3.2.1.67 +xref: MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN +xref: RHEA:14117 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047912 +name: galacturonokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+)." [EC:2.7.1.44, RHEA:12965] +synonym: "ATP:D-galacturonate 1-phosphotransferase activity" RELATED [EC:2.7.1.44] +synonym: "galacturonokinase (phosphorylating) D-galacturonic acid kinase activity" RELATED [EC:2.7.1.44] +xref: EC:2.7.1.44 +xref: KEGG_REACTION:R01980 +xref: MetaCyc:GALACTURONOKINASE-RXN +xref: RHEA:12965 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047913 +name: gallate 1-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." [EC:2.4.1.136, RHEA:15249] +synonym: "gallate 1-b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose-vanillate 1-glucosyltransferase activity" RELATED [EC:2.4.1.136] +synonym: "UDP-glucose:gallate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.136] +synonym: "UDPglucose-vanillate 1-glucosyltransferase activity" RELATED [EC:2.4.1.136] +synonym: "UDPglucose:gallate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.136] +synonym: "UDPglucose:gallate glucosyltransferase activity" RELATED [EC:2.4.1.136] +synonym: "UDPglucose:vanillate 1-O-glucosyltransferase activity" RELATED [EC:2.4.1.136] +xref: EC:2.4.1.136 +xref: KEGG_REACTION:R03297 +xref: MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:15249 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047914 +name: gamma-glutamylhistamine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown." [EC:6.3.2.18, MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN] +synonym: "g-glutamylhistamine synthase activity" EXACT [] +synonym: "gamma-GHA synthetase activity" RELATED [EC:6.3.2.18] +synonym: "gamma-glutaminylhistamine synthetase activity" RELATED [EC:6.3.2.18] +synonym: "L-glutamate:histamine ligase activity" RELATED [EC:6.3.2.18] +xref: EC:6.3.2.18 +xref: MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN +xref: RHEA:18881 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047915 +name: ganglioside galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine." [EC:2.4.1.62, MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN] +synonym: "GM1-synthase activity" RELATED [EC:2.4.1.62] +synonym: "UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDP-galactose-GM2 galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDP-galactose-GM2 ganglioside galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDPgalactose-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "uridine diphosphate D-galactose:glycolipid galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "uridine diphosphogalactose-ceramide galactosyltransferase activity" RELATED [EC:2.4.1.62] +synonym: "uridine diphosphogalactose-GM2 galactosyltransferase activity" RELATED [EC:2.4.1.62] +xref: EC:2.4.1.62 +xref: MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN +xref: RHEA:16773 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0047916 +name: GDP-6-deoxy-D-talose 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+." [EC:1.1.1.135, MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN] +synonym: "GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity" RELATED [EC:1.1.1.135] +synonym: "guanosine diphospho-6-deoxy-D-talose dehydrogenase activity" RELATED [EC:1.1.1.135] +xref: EC:1.1.1.135 +xref: MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047917 +name: GDP-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+)." [EC:3.2.1.42, RHEA:15049] +synonym: "GDP-glucose glucohydrolase activity" RELATED [EC:3.2.1.42] +synonym: "GDPglucose glucohydrolase activity" RELATED [EC:3.2.1.42] +synonym: "GDPglucosidase activity" RELATED [EC:3.2.1.42] +synonym: "guanosine diphosphate D-glucose glucohydrolase activity" RELATED [EC:3.2.1.42] +synonym: "guanosine diphosphoglucosidase activity" RELATED [EC:3.2.1.42] +xref: EC:3.2.1.42 +xref: KEGG_REACTION:R00337 +xref: MetaCyc:GDP-GLUCOSIDASE-RXN +xref: RHEA:15049 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0047918 +name: GDP-mannose 3,5-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose = GDP-L-galactose." [EC:5.1.3.18] +synonym: "GDP-D-mannose:GDP-L-galactose epimerase activity" RELATED [EC:5.1.3.18] +synonym: "GDPmannose 3,5-epimerase activity" RELATED [EC:5.1.3.18] +synonym: "guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity" RELATED [EC:5.1.3.18] +xref: EC:5.1.3.18 +xref: MetaCyc:RXN-1882 +xref: RHEA:11144 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047919 +name: GDP-mannose 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH." [EC:1.1.1.132, RHEA:21728] +synonym: "GDP mannose dehydrogenase activity" RELATED [EC:1.1.1.132] +synonym: "GDP-D-mannose:NAD+ 6-oxidoreductase activity" RELATED [EC:1.1.1.132] +synonym: "GDPmannose 6-dehydrogenase activity" RELATED [EC:1.1.1.132] +synonym: "guanosine diphospho-D-mannose dehydrogenase activity" RELATED [EC:1.1.1.132] +synonym: "guanosine diphosphomannose dehydrogenase activity" RELATED [EC:1.1.1.132] +xref: EC:1.1.1.132 +xref: KEGG_REACTION:R00880 +xref: MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN +xref: RHEA:21728 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047920 +name: geissoschizine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH." [EC:1.3.1.36, RHEA:11376] +synonym: "geissoschizine:NADP+ 4,21-oxidoreductase activity" RELATED [EC:1.3.1.36] +xref: EC:1.3.1.36 +xref: KEGG_REACTION:R03860 +xref: MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN +xref: RHEA:11376 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047921 +name: aminoglycoside 2'-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring." [EC:2.3.1.59, RHEA:24516] +synonym: "acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] +synonym: "acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity" NARROW [EC:2.3.1.59] +synonym: "gentamicin 2'-N-acetyltransferase activity" NARROW [] +synonym: "gentamicin acetyltransferase II activity" NARROW [EC:2.3.1.59] +synonym: "gentamycin 2'-N-acetyltransferase activity" NARROW [] +synonym: "gentamycin acetyltransferase II" RELATED [EC:2.3.1.59] +xref: EC:2.3.1.59 +xref: KEGG_REACTION:R03056 +xref: MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN +xref: RHEA:24516 +is_a: GO:0034069 ! aminoglycoside N-acetyltransferase activity + +[Term] +id: GO:0047922 +name: gentisate 1,2-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+)." [EC:1.13.11.4, RHEA:18237] +synonym: "2,5-dihydroxybenzoate dioxygenase activity" RELATED [EC:1.13.11.4] +synonym: "gentisate dioxygenase activity" RELATED [EC:1.13.11.4] +synonym: "gentisate oxygenase activity" RELATED [EC:1.13.11.4] +synonym: "gentisate:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.4] +synonym: "gentisic acid oxidase activity" RELATED [EC:1.13.11.4] +xref: EC:1.13.11.4 +xref: KEGG_REACTION:R02656 +xref: MetaCyc:GENTISATE-12-DIOXYGENASE-RXN +xref: RHEA:18237 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0047923 +name: gentisate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone." [EC:4.1.1.62, RHEA:21312] +synonym: "2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)" RELATED [EC:4.1.1.62] +synonym: "2,5-dihydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.62] +synonym: "gentisate carboxy-lyase activity" RELATED [EC:4.1.1.62] +xref: EC:4.1.1.62 +xref: KEGG_REACTION:R02489 +xref: MetaCyc:GENTISATE-DECARBOXYLASE-RXN +xref: RHEA:21312 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047924 +name: geraniol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH." [EC:1.1.1.183, MetaCyc:GERANIOL-DEHYDROGENASE-RXN] +synonym: "geraniol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.183] +xref: EC:1.1.1.183 +xref: MetaCyc:GERANIOL-DEHYDROGENASE-RXN +xref: RHEA:14521 +xref: UM-BBD_reactionID:r1163 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047925 +name: geranoyl-CoA carboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.5, RHEA:17701] +synonym: "geranoyl coenzyme A carboxylase activity" RELATED [EC:6.4.1.5] +synonym: "geranoyl-CoA:carbon-dioxide ligase (ADP-forming)" RELATED [EC:6.4.1.5] +synonym: "geranyl-CoA carboxylase activity" RELATED [EC:6.4.1.5] +xref: EC:6.4.1.5 +xref: KEGG_REACTION:R03494 +xref: MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN +xref: RHEA:17701 +xref: UM-BBD_reactionID:r1166 +is_a: GO:0016421 ! CoA carboxylase activity + +[Term] +id: GO:0047926 +name: geranyl-diphosphate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate." [EC:5.5.1.8, RHEA:18209] +synonym: "(+)-bornyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.8] +synonym: "(+)-bornylpyrophosphate cyclase activity" RELATED [EC:5.5.1.8] +synonym: "bornyl diphosphate synthase activity" RELATED [EC:5.5.1.8] +synonym: "bornyl pyrophosphate synthase activity" RELATED [EC:5.5.1.8] +synonym: "bornyl pyrophosphate synthetase activity" RELATED [EC:5.5.1.8] +xref: EC:5.5.1.8 +xref: KEGG_REACTION:R02007 +xref: MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN +xref: RHEA:18209 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0047927 +name: gibberellin-44 dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2." [EC:1.14.11.12, MetaCyc:GIBBERELLIN-44-DIOXYGENASE-RXN] +synonym: "(gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.11.12] +synonym: "(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.11.12] +synonym: "gibberellin A44 oxidase activity" RELATED [EC:1.14.11.12] +synonym: "oxygenase, gibberellin A44 oxidase activity" RELATED [EC:1.14.11.12] +xref: EC:1.14.11.12 +xref: MetaCyc:RXN1F-168 +xref: RHEA:16033 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0047928 +name: gibberellin beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside." [EC:2.4.1.176, MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "gibberellin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.176] +synonym: "UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.176] +synonym: "uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity" RELATED [EC:2.4.1.176] +synonym: "uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity" RELATED [EC:2.4.1.176] +xref: EC:2.4.1.176 +xref: MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:20025 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0047929 +name: gluconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.39, RHEA:21612] +synonym: "D-gluconate dehydratase activity" RELATED [EC:4.2.1.39] +synonym: "D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.2.1.39] +synonym: "D-gluconate hydro-lyase activity" RELATED [EC:4.2.1.39] +xref: EC:4.2.1.39 +xref: KEGG_REACTION:R01538 +xref: MetaCyc:GLUCONATE-DEHYDRATASE-RXN +xref: RHEA:21612 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0047930 +name: glucosaminate ammonia-lyase activity +namespace: molecular_function +alt_id: GO:0050443 +def: "Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3." [EC:4.3.1.9, MetaCyc:GLUCOSAMINATE-AMMONIA-LYASE-RXN] +comment: Note that this function was EC:4.3.1.21. +synonym: "2-amino-2-deoxy-D-gluconate ammonia-lyase activity" RELATED [EC:4.3.1.9] +synonym: "2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity" RELATED [EC:4.3.1.9] +synonym: "acetylenemonocarboxylic acid hydrase activity" RELATED [EC:4.3.1.9] +synonym: "aminodeoxygluconate ammonia-lyase activity" EXACT [] +synonym: "aminodeoxygluconate dehydratase activity" EXACT [] +synonym: "D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)" RELATED [EC:4.3.1.9] +synonym: "D-glucosaminate ammonia-lyase activity" RELATED [EC:4.3.1.9] +synonym: "D-glucosaminate dehydratase activity" RELATED [EC:4.3.1.9] +synonym: "D-glucosaminic acid dehydrase activity" RELATED [EC:4.3.1.9] +synonym: "glucosaminic dehydrase activity" RELATED [EC:4.3.1.9] +xref: EC:4.3.1.9 +xref: MetaCyc:4.3.1.21-RXN +xref: RHEA:12488 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0047931 +name: glucosamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate." [EC:2.7.1.8, MetaCyc:GLUCOSAMINE-KINASE-RXN] +synonym: "aminodeoxyglucose kinase activity" RELATED [EC:2.7.1.8] +synonym: "ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity" RELATED [EC:2.7.1.8] +synonym: "ATP:D-glucosamine phosphotransferase activity" RELATED [EC:2.7.1.8] +synonym: "glucosamine kinase (phosphorylating)" RELATED [EC:2.7.1.8] +xref: EC:2.7.1.8 +xref: MetaCyc:GLUCOSAMINE-KINASE-RXN +xref: RHEA:10948 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047932 +name: glucosamine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+)." [EC:2.3.1.3, RHEA:21332] +synonym: "acetyl-CoA:D-glucosamine N-acetyltransferase activity" RELATED [EC:2.3.1.3] +synonym: "glucosamine acetylase activity" RELATED [EC:2.3.1.3] +synonym: "glucosamine acetyltransferase activity" RELATED [EC:2.3.1.3] +xref: EC:2.3.1.3 +xref: KEGG_REACTION:R01204 +xref: MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:21332 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047933 +name: glucose-1,6-bisphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+)." [EC:2.7.1.106, RHEA:16769] +synonym: "3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.106] +synonym: "3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.106] +synonym: "glucose 1,6-diphosphate synthase activity" RELATED [EC:2.7.1.106] +synonym: "glucose-1,6-bisphosphate synthetase activity" RELATED [EC:2.7.1.106] +xref: EC:2.7.1.106 +xref: KEGG_REACTION:R01660 +xref: MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN +xref: Reactome:R-HSA-8955760 "PGM2L1:Mg2+ phosphorylates G6P to G1,6BP" +xref: RHEA:16769 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047934 +name: glucose 1-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH." [EC:1.1.1.118, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN] +synonym: "D-aldohexose dehydrogenase activity" RELATED [EC:1.1.1.118] +synonym: "D-glucose:NAD oxidoreductase activity" RELATED [EC:1.1.1.118] +synonym: "D-glucose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.118] +xref: EC:1.1.1.118 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN +xref: RHEA:14293 +is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)] activity + +[Term] +id: GO:0047935 +name: glucose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH." [EC:1.1.1.119, MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN] +synonym: "D-glucose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.119] +synonym: "NADP-dependent glucose dehydrogenase activity" RELATED [EC:1.1.1.119] +synonym: "NADP-linked aldohexose dehydrogenase activity" RELATED [EC:1.1.1.119] +synonym: "nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity" RELATED [EC:1.1.1.119] +xref: EC:1.1.1.119 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN +xref: RHEA:14405 +is_a: GO:0047936 ! glucose 1-dehydrogenase [NAD(P)] activity + +[Term] +id: GO:0047936 +name: glucose 1-dehydrogenase [NAD(P)] activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H." [EC:1.1.1.47] +synonym: "beta-D-glucose:NAD(P)+ 1-oxidoreductase activity" RELATED [EC:1.1.1.47] +synonym: "D-glucose dehydrogenase (NAD(P))" RELATED [EC:1.1.1.47] +synonym: "hexose phosphate dehydrogenase activity" RELATED [EC:1.1.1.47] +xref: EC:1.1.1.47 +xref: MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN +is_a: GO:0004344 ! glucose dehydrogenase activity +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047937 +name: glucose-1-phosphate phosphodismutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate." [EC:2.7.1.41, MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN] +synonym: "D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.41] +synonym: "glucose 1-phosphate transphosphorylase activity" RELATED [EC:2.7.1.41] +synonym: "phosphodismutase activity" RELATED [EC:2.7.1.41] +xref: EC:2.7.1.41 +xref: MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN +xref: RHEA:16397 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047938 +name: glucose-6-phosphate 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate." [EC:5.1.3.15, MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN] +synonym: "D-glucose-6-phosphate 1-epimerase activity" RELATED [EC:5.1.3.15] +synonym: "glucose-6 phosphate 1-epimerase activity" EXACT [] +xref: EC:5.1.3.15 +xref: MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN +xref: RHEA:16249 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0047939 +name: L-glucuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH." [EC:1.1.1.19, RHEA:14909] +synonym: "aldehyde reductase II activity" RELATED [EC:1.1.1.19] +synonym: "D-glucuronate dehydrogenase activity" RELATED [EC:1.1.1.19] +synonym: "D-glucuronate reductase activity" NARROW [EC:1.1.1.19] +synonym: "glucuronate dehydrogenase activity" RELATED [EC:1.1.1.19] +synonym: "glucuronate reductase activity" EXACT [] +synonym: "NADP-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.19] +synonym: "TPN-L-gulonate dehydrogenase activity" RELATED [EC:1.1.1.19] +xref: EC:1.1.1.19 +xref: KEGG_REACTION:R01481 +xref: MetaCyc:GLUCURONATE-REDUCTASE-RXN +xref: Reactome:R-HSA-5661256 "AKR1A1 reduces D-glucuronate to L-gulonate" +xref: RHEA:14909 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047940 +name: glucuronokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+)." [EC:2.7.1.43, RHEA:17005] +synonym: "ATP:D-glucuronate 1-phosphotransferase activity" RELATED [EC:2.7.1.43] +synonym: "glucurono-glucuronokinase activity" RELATED [EC:2.7.1.43] +synonym: "glucuronokinase (phosphorylating)" RELATED [EC:2.7.1.43] +xref: EC:2.7.1.43 +xref: KEGG_REACTION:R01476 +xref: MetaCyc:GLUCURONOKINASE-RXN +xref: RHEA:17005 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047941 +name: glucuronolactone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH." [EC:1.1.1.20, RHEA:18925] +xref: EC:1.1.1.20 +xref: KEGG_REACTION:R03183 +xref: MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN +xref: RHEA:18925 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047942 +name: glutamate-ethylamine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.6, RHEA:20525] +synonym: "L-glutamate:ethylamine ligase (ADP-forming)" RELATED [EC:6.3.1.6] +synonym: "N(5)-ethyl-L-glutamine synthetase activity" RELATED [EC:6.3.1.6] +synonym: "N5-ethyl-L-glutamine synthetase activity" RELATED [EC:6.3.1.6] +synonym: "N5-ethylglutamine synthetase activity" RELATED [EC:6.3.1.6] +synonym: "theanine synthetase activity" RELATED [EC:6.3.1.6] +xref: EC:6.3.1.6 +xref: KEGG_REACTION:R02929 +xref: MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN +xref: RHEA:20525 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0047943 +name: glutamate-methylamine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.12, RHEA:17117] +synonym: "gamma-glutamylmethylamide synthetase activity" RELATED [EC:6.3.4.12] +synonym: "L-glutamate:methylamine ligase (ADP-forming)" RELATED [EC:6.3.4.12] +xref: EC:6.3.4.12 +xref: KEGG_REACTION:R01585 +xref: MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN +xref: RHEA:17117 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0047944 +name: obsolete glutamate 1-kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-glutamate + ATP = alpha-L-glutamyl phosphate + ADP + H(+)." [GOC:curators] +comment: This term is slated for obsoletion. RHEA indicates the activity has been shown not to exist. +synonym: "ATP:L-glutamate 1-phosphotransferase activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0047945 +name: L-glutamine:pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine." [EC:2.6.1.15, RHEA:10400] +synonym: "gamma-glutaminyltransferase activity" RELATED [EC:2.6.1.15] +synonym: "glutaminase II activity" RELATED [EC:2.6.1.15] +synonym: "glutamine transaminase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine transaminase L activity" BROAD [EC:2.6.1.15] +synonym: "glutamine--oxo-acid transaminase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine--pyruvate aminotransferase activity" BROAD [] +synonym: "glutamine-alpha-keto acid transamidase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine-alpha-keto acid transaminase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine-keto acid aminotransferase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine-oxo acid aminotransferase activity" BROAD [EC:2.6.1.15] +synonym: "glutamine-pyruvate transaminase activity" BROAD [EC:2.6.1.15] +synonym: "L-glutamine transaminase L" RELATED [EC:2.6.1.15] +xref: EC:2.6.1.15 +xref: KEGG_REACTION:R00576 +xref: MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN +xref: Reactome:R-HSA-893616 "glutamine + pyruvate => 2-oxoglutaramate + alanine" +xref: RHEA:10400 +is_a: GO:0070548 ! L-glutamine aminotransferase activity + +[Term] +id: GO:0047946 +name: glutamine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine." [EC:2.3.1.68, MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:L-glutamine N-acyltransferase activity" RELATED [EC:2.3.1.68] +xref: EC:2.3.1.68 +xref: MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN +xref: RHEA:18469 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0047947 +name: glutamine N-phenylacetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine." [EC:2.3.1.14, MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN] +synonym: "glutamine phenylacetyltransferase activity" RELATED [EC:2.3.1.14] +synonym: "phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity" RELATED [EC:2.3.1.14] +synonym: "phenylacetyl-CoA:L-glutamine N-acetyltransferase activity" RELATED [EC:2.3.1.14] +xref: EC:2.3.1.14 +xref: MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN +xref: RHEA:21844 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047948 +name: glutarate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate." [EC:6.2.1.6, RHEA:14169] +synonym: "glutarate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.6] +synonym: "glutaryl coenzyme A synthetase activity" RELATED [EC:6.2.1.6] +synonym: "glutaryl-CoA synthetase activity" RELATED [EC:6.2.1.6] +xref: EC:6.2.1.6 +xref: KEGG_REACTION:R02402 +xref: MetaCyc:GLUTARATE--COA-LIGASE-RXN +xref: RHEA:14169 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0047949 +name: glutarate-semialdehyde dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH." [EC:1.2.1.20, MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN] +synonym: "glutarate semialdehyde dehydrogenase (NAD+) activity" EXACT [] +synonym: "glutarate-semialdehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.20] +xref: EC:1.2.1.20 +xref: MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:12064 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047950 +name: glutathione oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2)." [EC:1.8.3.3, RHEA:24112] +synonym: "glutathione:oxygen oxidoreductase activity" RELATED [EC:1.8.3.3] +xref: EC:1.8.3.3 +xref: KEGG_REACTION:R00120 +xref: MetaCyc:GLUTATHIONE-OXIDASE-RXN +xref: RHEA:24112 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0047951 +name: glutathione thiolesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+)." [EC:3.1.2.7, RHEA:22708] +synonym: "citryl-glutathione thioesterhydrolase activity" RELATED [EC:3.1.2.7] +synonym: "glutathione thioesterase activity" EXACT [] +synonym: "S-acylglutathione hydrolase activity" RELATED [EC:3.1.2.7] +xref: EC:3.1.2.7 +xref: KEGG_REACTION:R00547 +xref: MetaCyc:GLUTATHIONE-THIOESTERASE-RXN +xref: RHEA:22708 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0047952 +name: glycerol-3-phosphate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +alt_id: GO:0036439 +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+." [RHEA:11096] +synonym: "glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity" RELATED [EC:1.1.1.94] +synonym: "glycerol-3-phosphate dehydrogenase (NAD(P)+) activity" EXACT [] +synonym: "L-glycerol-3-phosphate:NAD(P) oxidoreductase activity" RELATED [EC:1.1.1.94] +synonym: "sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.94] +xref: EC:1.1.1.94 +xref: KEGG_REACTION:R00844 +xref: MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047953 +name: glycerol 2-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH." [EC:1.1.1.156, RHEA:12753] +synonym: "DHA oxidoreductase activity" RELATED [EC:1.1.1.156] +synonym: "dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.156] +synonym: "dihydroxyacetone reductase (NADPH)" RELATED [EC:1.1.1.156] +synonym: "dihydroxyacetone reductase activity" RELATED [EC:1.1.1.156] +synonym: "glycerol:NADP+ 2-oxidoreductase (glycerone-forming)" RELATED [EC:1.1.1.156] +xref: EC:1.1.1.156 +xref: KEGG_REACTION:R01039 +xref: MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN +xref: RHEA:12753 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047954 +name: glycerol-2-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate." [EC:3.1.3.19, RHEA:13105] +synonym: "2-glycerophosphatase activity" RELATED [EC:3.1.3.19] +synonym: "beta-glycerophosphatase activity" RELATED [EC:3.1.3.19] +synonym: "beta-glycerophosphate phosphatase activity" RELATED [EC:3.1.3.19] +synonym: "glycerol-2-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.19] +xref: EC:3.1.3.19 +xref: KEGG_REACTION:R01043 +xref: MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN +xref: RHEA:13105 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0047955 +name: glycerol dehydrogenase (acceptor) activity +namespace: molecular_function +def: "Catalysis of the reaction: A + glycerol = AH(2) + glycerone." [EC:1.1.99.22, RHEA:17493] +synonym: "glycerol:(acceptor) 1-oxidoreductase activity" RELATED [EC:1.1.99.22] +synonym: "glycerol:acceptor 1-oxidoreductase activity" RELATED [EC:1.1.99.22] +xref: EC:1.1.99.22 +xref: KEGG_REACTION:R01045 +xref: MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN +xref: RHEA:17493 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047956 +name: glycerol dehydrogenase [NADP+] activity +namespace: molecular_function +def: "Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH." [EC:1.1.1.72, MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN] +synonym: "glycerol dehydrogenase (NADP+) activity" RELATED [] +synonym: "glycerol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.72] +xref: EC:1.1.1.72 +xref: MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:23592 +is_a: GO:1990042 ! glycerol dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0047957 +name: 4'-methoxyisoflavone 2'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O." [EC:1.14.14.89, MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN] +synonym: "formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)" RELATED [EC:1.14.14.89] +synonym: "isoflavone 2'-monooxygenase activity" BROAD [EC:1.14.14.89] +xref: EC:1.14.14.89 +xref: MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN +xref: RHEA:12388 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0047958 +name: glycine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate." [EC:2.6.1.4, MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN] +synonym: "glutamate-glyoxylate transaminase activity" EXACT [] +synonym: "glutamic-glyoxylic transaminase activity" RELATED [EC:2.6.1.4] +synonym: "glycine aminotransferase activity" BROAD [] +synonym: "glycine transaminase activity" BROAD [EC:2.6.1.4] +synonym: "glyoxylate-glutamate aminotransferase activity" RELATED [EC:2.6.1.4] +synonym: "glyoxylate-glutamic transaminase activity" RELATED [EC:2.6.1.4] +synonym: "L-glutamate:glyoxylate aminotransferase activity" EXACT [] +xref: EC:2.6.1.4 +xref: MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN +xref: RHEA:14089 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0047959 +name: glycine dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c." [EC:1.4.2.1, MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN] +synonym: "glycine-cytochrome c reductase activity" RELATED [EC:1.4.2.1] +synonym: "glycine:ferricytochrome-c oxidoreductase (deaminating)" RELATED [EC:1.4.2.1] +synonym: "reductase, glycine-cytochrome c" RELATED [EC:1.4.2.1] +xref: EC:1.4.2.1 +xref: MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:16909 +is_a: GO:0016640 ! oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor + +[Term] +id: GO:0047960 +name: glycine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH." [EC:1.4.1.10, MetaCyc:GLYCINE-DEHYDROGENASE-RXN] +synonym: "glycine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.10] +xref: EC:1.4.1.10 +xref: MetaCyc:GLYCINE-DEHYDROGENASE-RXN +xref: RHEA:15721 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047961 +name: glycine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine." [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:glycine N-acyltransferase activity" RELATED [EC:2.3.1.13] +synonym: "glycine acyltransferase activity" RELATED [EC:2.3.1.13] +synonym: "glycine-N-acylase activity" RELATED [EC:2.3.1.13] +xref: EC:2.3.1.13 +xref: MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-2534040 "Unknown NAT N-acylates Gly in GNAT1" +xref: RHEA:19869 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0047962 +name: glycine N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)." [EC:2.3.1.71, RHEA:18493] +synonym: "benzoyl CoA-amino acid N-acyltransferase activity" RELATED [EC:2.3.1.71] +synonym: "benzoyl-CoA:glycine N-acyltransferase activity" RELATED [EC:2.3.1.71] +synonym: "benzoyl-CoA:glycine N-benzoyltransferase activity" RELATED [EC:2.3.1.71] +xref: EC:2.3.1.71 +xref: KEGG_REACTION:R02452 +xref: MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN +xref: Reactome:R-HSA-159566 "benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A" +xref: Reactome:R-HSA-159574 "salicylate-CoA + glycine => salicyluric acid + Coenzyme A" +xref: RHEA:18493 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047963 +name: glycine N-choloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate." [EC:2.3.1.65, MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN] +synonym: "amino acid N-choloyltransferase activity" RELATED [EC:2.3.1.65] +synonym: "BACAT activity" RELATED [EC:2.3.1.65] +synonym: "BAT activity" RELATED [EC:2.3.1.65] +synonym: "bile acid-CoA:amino acid N-acyltransferase activity" RELATED [EC:2.3.1.65] +synonym: "choloyl-CoA:glycine N-choloyltransferase activity" RELATED [EC:2.3.1.65] +synonym: "cholyl-CoA glycine-taurine N-acyltransferase activity" RELATED [EC:2.3.1.65] +synonym: "cholyl-CoA:taurine N-acyltransferase activity" RELATED [EC:2.3.1.65] +synonym: "glycine--taurine N-acyltransferase activity" RELATED [EC:2.3.1.65] +xref: EC:2.3.1.65 +xref: MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN +xref: RHEA:14001 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0047964 +name: glyoxylate reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH." [RHEA:18229] +synonym: "glycolate reductase activity" RELATED [EC:1.1.1.26] +synonym: "glyoxylic acid reductase activity" RELATED [EC:1.1.1.26] +synonym: "NADH-dependent glyoxylate reductase activity" RELATED [EC:1.1.1.26] +xref: EC:1.1.1.26 +xref: MetaCyc:GLYCOLATE-REDUCTASE-RXN +xref: RHEA:18229 +is_a: GO:0106345 ! glyoxylate reductase activity + +[Term] +id: GO:0047965 +name: glycoprotein O-fatty-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein." [EC:2.3.1.142, MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN] +synonym: "fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity" RELATED [EC:2.3.1.142] +synonym: "protein acyltransferase activity" RELATED [EC:2.3.1.142] +xref: EC:2.3.1.142 +xref: MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN +is_a: GO:0016416 ! O-palmitoyltransferase activity +is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein + +[Term] +id: GO:0047966 +name: glycosulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate." [EC:3.1.6.3, RHEA:19145] +synonym: "glucosulfatase activity" RELATED [EC:3.1.6.3] +synonym: "glycosulphatase activity" EXACT [] +synonym: "sugar-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.3] +xref: EC:3.1.6.3 +xref: KEGG_REACTION:R00534 +xref: MetaCyc:GLYCOSULFATASE-RXN +xref: RHEA:19145 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0047967 +name: glycyrrhizinate beta-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate." [EC:3.2.1.128, RHEA:17369] +synonym: "glycyrrhizin beta-hydrolase activity" RELATED [EC:3.2.1.128] +synonym: "glycyrrhizin hydrolase activity" RELATED [EC:3.2.1.128] +synonym: "glycyrrhizinate b-glucuronidase activity" EXACT [] +synonym: "glycyrrhizinate glucuronosylhydrolase activity" RELATED [EC:3.2.1.128] +synonym: "glycyrrhizinic acid hydrolase activity" RELATED [EC:3.2.1.128] +xref: EC:3.2.1.128 +xref: KEGG_REACTION:R03906 +xref: MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN +xref: RHEA:17369 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0047968 +name: glyoxylate dehydrogenase (acylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA." [EC:1.2.1.17, RHEA:21024] +synonym: "glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)" RELATED [EC:1.2.1.17] +xref: EC:1.2.1.17 +xref: KEGG_REACTION:R00468 +xref: MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN +xref: RHEA:21024 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047969 +name: glyoxylate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate." [EC:1.2.3.5, RHEA:14837] +synonym: "glyoxylate:oxygen oxidoreductase activity" RELATED [EC:1.2.3.5] +xref: EC:1.2.3.5 +xref: KEGG_REACTION:R00466 +xref: MetaCyc:GLYOXYLATE-OXIDASE-RXN +xref: Reactome:R-HSA-389862 "Conversion of glyoxylate to oxalate" +xref: RHEA:14837 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0047970 +name: guanidinoacetase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea." [EC:3.5.3.2, RHEA:23268] +synonym: "glycocyaminase activity" RELATED [EC:3.5.3.2] +synonym: "guanidinoacetate amidinohydrolase activity" RELATED [EC:3.5.3.2] +xref: EC:3.5.3.2 +xref: KEGG_REACTION:R00775 +xref: MetaCyc:GUANIDINOACETASE-RXN +xref: RHEA:23268 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047971 +name: guanidinobutyrase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea." [EC:3.5.3.7, RHEA:19501] +synonym: "4-guanidinobutanoate amidinohydrolase activity" RELATED [EC:3.5.3.7] +synonym: "4-guanidinobutyrate amidinobutyrase activity" RELATED [EC:3.5.3.7] +synonym: "G-base activity" RELATED [EC:3.5.3.7] +synonym: "gamma-guanidinobutyrate amidinohydrolase activity" RELATED [EC:3.5.3.7] +synonym: "gamma-guanidobutyrase activity" RELATED [EC:3.5.3.7] +synonym: "GBH" RELATED [EC:3.5.3.7] +synonym: "guanidinobutyrate ureahydrolase activity" RELATED [EC:3.5.3.7] +xref: EC:3.5.3.7 +xref: KEGG_REACTION:R01990 +xref: MetaCyc:GUANIDINOBUTYRASE-RXN +xref: RHEA:19501 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047972 +name: guanidinopropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea." [EC:3.5.3.17, RHEA:16029] +synonym: "3-guanidinopropanoate amidinopropionase activity" RELATED [EC:3.5.3.17] +synonym: "GPase activity" RELATED [EC:3.5.3.17] +synonym: "GPH" RELATED [EC:3.5.3.17] +xref: EC:3.5.3.17 +xref: KEGG_REACTION:R00913 +xref: MetaCyc:GUANIDINOPROPIONASE-RXN +xref: RHEA:16029 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0047973 +name: guanidinoacetate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate." [EC:2.7.3.1, RHEA:14145] +synonym: "ATP:guanidinoacetate N-phosphotransferase activity" RELATED [EC:2.7.3.1] +synonym: "glycocyamine kinase activity" RELATED [EC:2.7.3.1] +synonym: "guanidoacetate kinase activity" EXACT [] +xref: EC:2.7.3.1 +xref: KEGG_REACTION:R02575 +xref: MetaCyc:GUANIDOACETATE-KINASE-RXN +xref: RHEA:14145 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0047974 +name: guanosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine + H2O = xanthosine + NH3." [EC:3.5.4.15, MetaCyc:GUANOSINE-DEAMINASE-RXN] +synonym: "guanosine aminase activity" RELATED [EC:3.5.4.15] +synonym: "guanosine aminohydrolase activity" RELATED [EC:3.5.4.15] +xref: EC:3.5.4.15 +xref: MetaCyc:GUANOSINE-DEAMINASE-RXN +xref: RHEA:12861 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0047975 +name: guanosine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate." [EC:2.4.2.15, MetaCyc:GUANPHOSPHOR-RXN] +synonym: "guanosine:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.15] +synonym: "guanosine:phosphate D-ribosyltransferase activity" RELATED [EC:2.4.2.15] +xref: EC:2.4.2.15 +xref: MetaCyc:GUANPHOSPHOR-RXN +xref: RHEA:13233 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0047976 +name: hamamelose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+)." [EC:2.7.1.102, RHEA:22796] +synonym: "ATP/hamamelose 2'-phosphotransferase activity" RELATED [EC:2.7.1.102] +synonym: "ATP:D-hamamelose 2'-phosphotransferase activity" RELATED [EC:2.7.1.102] +synonym: "hamamelose kinase (phosphorylating)" RELATED [EC:2.7.1.102] +synonym: "hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)" RELATED [EC:2.7.1.102] +xref: EC:2.7.1.102 +xref: KEGG_REACTION:R03766 +xref: MetaCyc:HAMAMELOSE-KINASE-RXN +xref: RHEA:22796 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0047977 +name: hepoxilin-epoxide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate." [EC:3.3.2.7, MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN] +synonym: "(5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity" RELATED [EC:3.3.2.7] +synonym: "hepoxilin A(3) hydrolase activity" RELATED [EC:3.3.2.7] +synonym: "hepoxilin A3 hydrolase activity" RELATED [EC:3.3.2.7] +synonym: "hepoxilin epoxide hydrolase activity" RELATED [EC:3.3.2.7] +synonym: "hepoxylin hydrolase activity" RELATED [EC:3.3.2.7] +xref: EC:3.3.2.7 +xref: MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN +xref: Reactome:R-HSA-2161949 "HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH" +xref: RHEA:16665 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0047978 +name: hexadecanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH." [EC:1.1.1.164, MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN] +synonym: "hexadecanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.164] +xref: EC:1.1.1.164 +xref: MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN +xref: RHEA:22056 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047979 +name: hexose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202." [EC:1.1.3.5, MetaCyc:HEXOSE-OXIDASE-RXN] +synonym: "D-hexose:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.5] +xref: EC:1.1.3.5 +xref: MetaCyc:HEXOSE-OXIDASE-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047980 +name: hippurate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine." [EC:3.5.1.32, RHEA:10424] +synonym: "benzoylglycine amidohydrolase activity" RELATED [EC:3.5.1.32] +synonym: "hippuricase activity" RELATED [EC:3.5.1.32] +synonym: "N-benzoylamino-acid amidohydrolase activity" RELATED [EC:3.5.1.32] +xref: EC:3.5.1.32 +xref: KEGG_REACTION:R01424 +xref: MetaCyc:HIPPURATE-HYDROLASE-RXN +xref: RHEA:10424 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0047981 +name: histidine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+)." [EC:2.3.1.33, RHEA:24596] +synonym: "acetyl-CoA:L-histidine N-acetyltransferase activity" RELATED [EC:2.3.1.33] +synonym: "acetylhistidine synthetase activity" RELATED [EC:2.3.1.33] +synonym: "histidine acetyltransferase activity" RELATED [EC:2.3.1.33] +xref: EC:2.3.1.33 +xref: KEGG_REACTION:R01160 +xref: MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:24596 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0047982 +name: homocysteine desulfhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate." [EC:4.4.1.2, MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN] +synonym: "homocysteine desulfurase activity" RELATED [EC:4.4.1.2] +synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating)" RELATED [EC:4.4.1.2] +synonym: "L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)" RELATED [EC:4.4.1.2] +xref: EC:4.4.1.2 +xref: MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN +xref: Reactome:R-HSA-1614631 "Homocysteine is degraded to oxobutanoate and H2S" +xref: RHEA:14501 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0047983 +name: homoglutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.23, RHEA:17993] +synonym: "beta-alanine specific hGSH synthetase activity" RELATED [EC:6.3.2.23] +synonym: "gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)" RELATED [EC:6.3.2.23] +synonym: "homoglutathione synthetase activity" RELATED [EC:6.3.2.23] +xref: EC:6.3.2.23 +xref: KEGG_REACTION:R02741 +xref: MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN +xref: RHEA:17993 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0047985 +name: hydrogen dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + NAD+ = H+ + NADH." [EC:1.12.1.2, MetaCyc:HYDROGEN-DEHYDROGENASE-RXN] +synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.1.2] +synonym: "H(2):NAD(+) oxidoreductase activity" RELATED [EC:1.12.1.2] +synonym: "H2:NAD+ oxidoreductase activity" RELATED [EC:1.12.1.2] +synonym: "hydrogen:NAD+ oxidoreductase activity" RELATED [EC:1.12.1.2] +synonym: "hydrogenase activity" BROAD [EC:1.12.1.2] +synonym: "NAD-linked hydrogenase activity" RELATED [EC:1.12.1.2] +xref: EC:1.12.1.2 +xref: MetaCyc:HYDROGEN-DEHYDROGENASE-RXN +xref: RHEA:24636 +is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor + +[Term] +id: GO:0047986 +name: hydrogen-sulfide S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." [EC:2.3.1.10, RHEA:16625] +synonym: "acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity" RELATED [EC:2.3.1.10] +synonym: "hydrogen-sulfide acetyltransferase activity" RELATED [EC:2.3.1.10] +synonym: "hydrogen-sulphide S-acetyltransferase activity" EXACT [] +xref: EC:2.3.1.10 +xref: KEGG_REACTION:R01850 +xref: MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN +xref: RHEA:16625 +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0047988 +name: hydroxyacid-oxoacid transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate." [EC:1.1.99.24, MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN] +synonym: "(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity" RELATED [EC:1.1.99.24] +synonym: "transhydrogenase, hydroxy acid-oxo acid" RELATED [EC:1.1.99.24] +xref: EC:1.1.99.24 +xref: MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN +xref: Reactome:R-HSA-880002 "(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate" +xref: Reactome:R-HSA-880033 "2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde" +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0047989 +name: hydroxybutyrate-dimer hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+)." [EC:3.1.1.22, RHEA:10172] +synonym: "(R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity" RELATED [EC:3.1.1.22] +synonym: "D-(-)-3-hydroxybutyrate-dimer hydrolase activity" RELATED [EC:3.1.1.22] +xref: EC:3.1.1.22 +xref: KEGG_REACTION:R00048 +xref: MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN +xref: RHEA:10172 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0047990 +name: hydroxyglutamate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2)." [EC:4.1.1.16, RHEA:14073] +synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming)" RELATED [EC:4.1.1.16] +synonym: "3-hydroxy-L-glutamate 1-carboxy-lyase activity" RELATED [EC:4.1.1.16] +xref: EC:4.1.1.16 +xref: KEGG_REACTION:R04135 +xref: MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN +xref: RHEA:14073 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047991 +name: hydroxylamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite." [RHEA:19969] +synonym: "HAO" RELATED [EC:1.7.3.6] +synonym: "hydroxylamine oxidoreductase" BROAD [EC:1.7.3.6] +synonym: "hydroxylamine:oxygen oxidoreductase activity" RELATED [EC:1.7.3.6] +xref: EC:1.7.3.6 +xref: KEGG_REACTION:R00793 +xref: MetaCyc:HAONITRO-RXN +xref: RHEA:19969 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0047992 +name: hydroxylysine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+)." [EC:2.7.1.81, RHEA:19049] +synonym: "GTP:5-hydroxy-L-lysine O-phosphotransferase activity" RELATED [EC:2.7.1.81] +synonym: "guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity" RELATED [EC:2.7.1.81] +synonym: "hydroxylysine kinase (phosphorylating)" RELATED [EC:2.7.1.81] +xref: EC:2.7.1.81 +xref: KEGG_REACTION:R03378 +xref: MetaCyc:HYDROXYLYSINE-KINASE-RXN +xref: Reactome:R-HSA-6788611 "HYKK phosphorylates 5HLYS" +xref: RHEA:19049 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019202 ! amino acid kinase activity + +[Term] +id: GO:0047993 +name: hydroxymalonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate." [EC:1.1.1.167, RHEA:11284] +synonym: "hydroxymalonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.167] +xref: EC:1.1.1.167 +xref: KEGG_REACTION:R02969 +xref: MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN +xref: RHEA:11284 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047994 +name: hydroxymethylglutaryl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+)." [EC:3.1.2.5, RHEA:16305] +synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity" RELATED [EC:3.1.2.5] +synonym: "3-hydroxy-3-methylglutaryl-CoA hydrolase activity" RELATED [EC:3.1.2.5] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity" RELATED [EC:3.1.2.5] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity" RELATED [EC:3.1.2.5] +synonym: "hydroxymethylglutaryl coenzyme A deacylase activity" RELATED [EC:3.1.2.5] +synonym: "hydroxymethylglutaryl coenzyme A hydrolase activity" RELATED [EC:3.1.2.5] +xref: EC:3.1.2.5 +xref: KEGG_REACTION:R02083 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN +xref: RHEA:16305 +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0047995 +name: hydroxyphenylpyruvate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH." [EC:1.1.1.237, MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN, RHEA:10780] +synonym: "4-hydroxyphenyllactate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.237] +synonym: "HPRP" RELATED [EC:1.1.1.237] +xref: EC:1.1.1.237 +xref: MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN +xref: RHEA:10780 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0047996 +name: hydroxyphytanate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2)." [EC:1.1.3.27, RHEA:21680] +synonym: "L-2-hydroxyphytanate:oxygen 2-oxidoreductase" BROAD [EC:1.1.3.27] +xref: EC:1.1.3.27 +xref: KEGG_REACTION:R07151 +xref: MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN +xref: RHEA:21680 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0047997 +name: hydroxypyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde." [EC:4.1.1.40, RHEA:20561] +synonym: "hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)" RELATED [EC:4.1.1.40] +synonym: "hydroxypyruvate carboxy-lyase activity" RELATED [EC:4.1.1.40] +xref: EC:4.1.1.40 +xref: KEGG_REACTION:R01393 +xref: MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN +xref: RHEA:20561 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0047998 +name: hyoscyamine (6S)-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate." [EC:1.14.11.11, RHEA:12629] +synonym: "hyoscyamine (6S)-hydroxylase activity" RELATED [EC:1.14.11.11] +synonym: "hyoscyamine 6-beta-hydroxylase activity" RELATED [EC:1.14.11.11] +synonym: "hyoscyamine 6-hydroxylase activity" RELATED [EC:1.14.11.11] +synonym: "hyoscyamine 6beta-dioxygenase activity" RELATED [EC:1.14.11.11] +synonym: "hyoscyamine 6beta-hydroxylase activity" RELATED [EC:1.14.11.11] +synonym: "L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)" RELATED [EC:1.14.11.11] +xref: EC:1.14.11.11 +xref: KEGG_REACTION:R03812 +xref: MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN +xref: RHEA:12629 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0047999 +name: hyponitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH." [EC:1.7.1.5, RHEA:19337] +synonym: "hydroxylamine:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.5] +synonym: "NADH2:hyponitrite oxidoreductase activity" RELATED [EC:1.7.1.5] +synonym: "NADH:hyponitrite oxidoreductase activity" RELATED [EC:1.7.1.5] +xref: EC:1.7.1.5 +xref: KEGG_REACTION:R00023 +xref: MetaCyc:HYPONITRITE-REDUCTASE-RXN +xref: RHEA:19337 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0048000 +name: isoflavone 3'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O." [EC:1.14.14.88, MetaCyc:ISOFLAVONE-3'-HYDROXYLASE-RXN] +synonym: "formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.88] +synonym: "isoflavone 3'-monooxygenase activity" RELATED [EC:1.14.14.88] +xref: EC:1.14.14.88 +xref: MetaCyc:RXN-3762 +xref: RHEA:22960 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0048001 +name: erythrose-4-phosphate dehydrogenase activity +namespace: molecular_function +alt_id: GO:0033724 +def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH." [EC:1.2.1.72, RHEA:12056] +synonym: "D-erythrose 4-phosphate:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.72] +synonym: "E4P dehydrogenase activity" RELATED [EC:1.2.1.72] +synonym: "E4PDH" RELATED [EC:1.2.1.72] +synonym: "Epd dehydrogenase activity" RELATED [EC:1.2.1.72] +synonym: "erythrose 4-phosphate dehydrogenase activity" RELATED [EC:1.2.1.72] +synonym: "GapB" RELATED [EC:1.2.1.72] +xref: EC:1.2.1.72 +xref: KEGG_REACTION:R01825 +xref: MetaCyc:ERYTH4PDEHYDROG-RXN +xref: RHEA:12056 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0048002 +name: antigen processing and presentation of peptide antigen +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein." [GOC:add, ISBN:0781735149, PMID:15771591] +synonym: "antigen presentation, peptide antigen" EXACT [] +synonym: "peptide antigen processing and presentation" EXACT [] +is_a: GO:0019882 ! antigen processing and presentation + +[Term] +id: GO:0048003 +name: antigen processing and presentation of lipid antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, lipid antigen" EXACT [] +synonym: "lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib + +[Term] +id: GO:0048006 +name: antigen processing and presentation, endogenous lipid antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, endogenous lipid antigen" EXACT [] +synonym: "endogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen +is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0048007 +name: antigen processing and presentation, exogenous lipid antigen via MHC class Ib +namespace: biological_process +def: "The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family." [GOC:add, PMID:10375559, PMID:15928678, PMID:15928680] +synonym: "antigen presentation, exogenous peptide antigen" EXACT [] +synonym: "exogenous lipid antigen processing and presentation via MHC class Ib" EXACT [] +is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen +is_a: GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib + +[Term] +id: GO:0048008 +name: platelet-derived growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "PDGF receptor signaling pathway" EXACT [] +synonym: "PDGF receptor signalling pathway" EXACT [] +synonym: "PDGFR signaling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048009 +name: insulin-like growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "IGF receptor signaling pathway" EXACT [] +synonym: "IGF receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048010 +name: vascular endothelial growth factor receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] +comment: In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. +synonym: "VEGF receptor signaling pathway" EXACT [] +synonym: "VEGF receptor signalling pathway" EXACT [] +synonym: "VEGFR signaling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048011 +name: neurotrophin TRK receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:ceb, GOC:jc, GOC:signaling, PMID:12065629, Wikipedia:Trk_receptor] +synonym: "TrkA signaling pathway" NARROW [Wikipedia:TrkA] +synonym: "TrkB signaling pathway" NARROW [Wikipedia:TrkB] +synonym: "TrkC signaling pathway" NARROW [Wikipedia:TrkC] +synonym: "tropomyosin-receptor-kinase signaling" EXACT [Wikipedia:Trk_receptor] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +is_a: GO:0038179 ! neurotrophin signaling pathway + +[Term] +id: GO:0048012 +name: hepatocyte growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands." [GOC:ceb] +synonym: "HGF receptor signaling pathway" EXACT [] +synonym: "HGF receptor signalling pathway" EXACT [] +synonym: "Met signaling pathway" NARROW [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048013 +name: ephrin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin." [GOC:ceb] +synonym: "Eph receptor signaling pathway" EXACT [] +synonym: "Eph receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048014 +name: Tie signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a Tie protein (a receptor) binding to one of its physiological ligands (an angiopoietin)." [GOC:ceb, GOC:signaling, PMID:11283723, PMID:11566266] +synonym: "angiopoietin-Tie signaling pathway" NARROW [PMID:22951441] +synonym: "angiopoietin/Tie signaling pathway" NARROW [PMID:11566266] +synonym: "Tek receptor signaling" EXACT [] +synonym: "Tie receptor signaling pathway" EXACT [GOC:ceb] +synonym: "Tie receptor signalling pathway" EXACT [] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway + +[Term] +id: GO:0048015 +name: phosphatidylinositol-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives." [GOC:bf, GOC:ceb, ISBN:0198506732] +synonym: "inositol phospholipid-mediated signaling" BROAD [] +synonym: "phosphatidylinositol-mediated signal transduction" EXACT [GOC:signaling] +synonym: "phosphatidylinositol-mediated signalling" EXACT [] +synonym: "phosphoinositide-mediated signaling" EXACT [] +synonym: "phosphoinositide-mediated signalling" EXACT [] +is_a: GO:0048017 ! inositol lipid-mediated signaling + +[Term] +id: GO:0048016 +name: inositol phosphate-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6)." [GOC:bf, GOC:ceb, GOC:signaling, ISBN:0198506732, PMID:11331907] +synonym: "inositol phosphate-mediated signalling" EXACT [] +is_a: GO:0019932 ! second-messenger-mediated signaling + +[Term] +id: GO:0048017 +name: inositol lipid-mediated signaling +namespace: biological_process +def: "A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids." [GOC:bf, GOC:ceb, PMID:16088939] +synonym: "inositol lipid-mediated signal transduction" EXACT [GOC:signaling] +synonym: "inositol lipid-mediated signalling" EXACT [] +synonym: "inositol phospholipid-mediated signaling" NARROW [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0048018 +name: receptor ligand activity +namespace: molecular_function +alt_id: GO:0071884 +def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] +subset: goslim_chembl +subset: goslim_drosophila +synonym: "receptor agonist activity" BROAD [GOC:molecular_function_refactoring] +synonym: "signaling molecule" EXACT [] +synonym: "signaling receptor ligand activity" EXACT [] +synonym: "vitamin D receptor activator activity" NARROW [] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0030546 ! signaling receptor activator activity + +[Term] +id: GO:0048019 +name: receptor antagonist activity +namespace: molecular_function +def: "The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor." [GOC:ceb, ISBN:0198506732] +synonym: "receptor ligand activity" BROAD [GOC:mtg_signaling] +is_a: GO:0005102 ! signaling receptor binding +is_a: GO:0030547 ! signaling receptor inhibitor activity + +[Term] +id: GO:0048020 +name: CCR chemokine receptor binding +namespace: molecular_function +def: "Binding to a CCR chemokine receptor." [GOC:ai] +synonym: "beta chemokine receptor binding" EXACT [] +synonym: "beta chemokine receptor ligand" NARROW [] +synonym: "CCR chemokine receptor ligand" NARROW [] +is_a: GO:0042379 ! chemokine receptor binding + +[Term] +id: GO:0048021 +name: regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that alters the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] +synonym: "regulation of melanin anabolism" EXACT [] +synonym: "regulation of melanin biosynthesis" EXACT [] +synonym: "regulation of melanin formation" EXACT [] +synonym: "regulation of melanin synthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048022 +name: negative regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] +synonym: "down regulation of melanin biosynthetic process" EXACT [] +synonym: "down-regulation of melanin biosynthetic process" EXACT [] +synonym: "downregulation of melanin biosynthetic process" EXACT [] +synonym: "inhibition of melanin biosynthetic process" NARROW [] +synonym: "negative regulation of melanin anabolism" EXACT [] +synonym: "negative regulation of melanin biosynthesis" EXACT [] +synonym: "negative regulation of melanin formation" EXACT [] +synonym: "negative regulation of melanin synthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0048021 ! regulation of melanin biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048023 +name: positive regulation of melanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the rate or extent of the chemical reactions and pathways resulting in the formation of melanin." [GOC:jid] +synonym: "activation of melanin biosynthetic process" NARROW [] +synonym: "positive regulation of melanin anabolism" EXACT [] +synonym: "positive regulation of melanin biosynthesis" EXACT [] +synonym: "positive regulation of melanin formation" EXACT [] +synonym: "positive regulation of melanin synthesis" EXACT [] +synonym: "stimulation of melanin biosynthetic process" NARROW [] +synonym: "up regulation of melanin biosynthetic process" EXACT [] +synonym: "up-regulation of melanin biosynthetic process" EXACT [] +synonym: "upregulation of melanin biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0048021 ! regulation of melanin biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0048024 +name: regulation of mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035055 +def: "Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] +synonym: "regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] +synonym: "regulation of pre-mRNA splicing" BROAD [] +is_a: GO:0043484 ! regulation of RNA splicing +is_a: GO:0050684 ! regulation of mRNA processing +relationship: regulates GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0048025 +name: negative regulation of mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035056 +def: "Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] +synonym: "down regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "down regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "down-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "down-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "downregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "downregulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "inhibition of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "inhibition of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "negative regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "negative regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] +synonym: "negative regulation of pre-mRNA splicing" BROAD [] +is_a: GO:0033119 ! negative regulation of RNA splicing +is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome +is_a: GO:0050686 ! negative regulation of mRNA processing +relationship: negatively_regulates GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0048026 +name: positive regulation of mRNA splicing, via spliceosome +namespace: biological_process +alt_id: GO:0035057 +def: "Any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism." [GOC:jid] +synonym: "activation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "activation of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "positive regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "positive regulation of nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] +synonym: "positive regulation of pre-mRNA splicing" BROAD [] +synonym: "stimulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "stimulation of nuclear mRNA splicing, via spliceosome" NARROW [] +synonym: "up regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "up regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "up-regulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "up-regulation of nuclear mRNA splicing, via spliceosome" EXACT [] +synonym: "upregulation of nuclear mRNA splicing via U2-type spliceosome" NARROW [] +synonym: "upregulation of nuclear mRNA splicing, via spliceosome" EXACT [] +is_a: GO:0033120 ! positive regulation of RNA splicing +is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome +is_a: GO:0050685 ! positive regulation of mRNA processing +relationship: positively_regulates GO:0000398 ! mRNA splicing, via spliceosome + +[Term] +id: GO:0048027 +name: mRNA 5'-UTR binding +namespace: molecular_function +def: "Binding to an mRNA molecule at its 5' untranslated region." [GOC:jid] +synonym: "mRNA 5' UTR binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0048028 +name: galacturonan binding +namespace: molecular_function +def: "Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins." [GOC:jid] +synonym: "polygalacturonide binding" RELATED [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:0048029 +name: monosaccharide binding +namespace: molecular_function +def: "Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:jid] +is_a: GO:0030246 ! carbohydrate binding +is_a: GO:0036094 ! small molecule binding + +[Term] +id: GO:0048030 +name: disaccharide binding +namespace: molecular_function +def: "Binding to a disaccharide. Disaccharides are sugars composed of two monosaccharide units." [GOC:jid] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0048031 +name: trisaccharide binding +namespace: molecular_function +def: "Binding to a trisaccharide. Trisaccharides are sugars composed of three monosaccharide units." [GOC:jid] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:0048032 +name: galacturonate binding +namespace: molecular_function +def: "Binding to a galacturonate. Galacturonate is the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:jid] +synonym: "galacturonic acid binding" EXACT [] +is_a: GO:0033293 ! monocarboxylic acid binding + +[Term] +id: GO:0048033 +name: heme O metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] +synonym: "haem O metabolic process" EXACT [] +synonym: "haem O metabolism" EXACT [] +synonym: "heme O metabolism" EXACT [] +is_a: GO:0042168 ! heme metabolic process + +[Term] +id: GO:0048034 +name: heme O biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] +synonym: "haem O biosynthesis" EXACT [] +synonym: "haem O biosynthetic process" EXACT [] +synonym: "heme O anabolism" EXACT [] +synonym: "heme O biosynthesis" EXACT [] +synonym: "heme O formation" EXACT [] +synonym: "heme O synthesis" EXACT [] +is_a: GO:0006783 ! heme biosynthetic process +is_a: GO:0048033 ! heme O metabolic process + +[Term] +id: GO:0048035 +name: heme O catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle." [GOC:jid] +synonym: "haem O catabolic process" EXACT [] +synonym: "haem O catabolism" EXACT [] +synonym: "heme O breakdown" EXACT [] +synonym: "heme O catabolism" EXACT [] +synonym: "heme O degradation" EXACT [] +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0048033 ! heme O metabolic process + +[Term] +id: GO:0048036 +name: central complex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli." [PMID:12490252] +synonym: "central body development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0048037 +name: obsolete cofactor binding +namespace: molecular_function +def: "OBSOLETE. Binding to a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a cofactor. +is_obsolete: true + +[Term] +id: GO:0048038 +name: quinone binding +namespace: molecular_function +def: "Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0048039 +name: ubiquinone binding +namespace: molecular_function +def: "Binding to ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089] +synonym: "coenzyme Q binding" EXACT [] +synonym: "coenzyme Q6 binding" NARROW [] +is_a: GO:0048038 ! quinone binding + +[Term] +id: GO:0048040 +name: UDP-glucuronate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose." [EC:4.1.1.35, RHEA:23916] +synonym: "UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)" RELATED [EC:4.1.1.35] +synonym: "UDP-D-glucuronate carboxy-lyase activity" RELATED [EC:4.1.1.35] +synonym: "UDP-glucuronic acid decarboxylase activity" EXACT [] +synonym: "UDPglucuronate decarboxylase activity" RELATED [EC:4.1.1.35] +synonym: "uridine-diphosphoglucuronate decarboxylase activity" RELATED [EC:4.1.1.35] +xref: EC:4.1.1.35 +xref: KEGG_REACTION:R01384 +xref: MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN +xref: RHEA:23916 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0048041 +name: focal adhesion assembly +namespace: biological_process +def: "The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity." [GOC:jid, GOC:mah] +synonym: "adhesion plaque assembly" RELATED [] +synonym: "focal adhesion formation" RELATED [GOC:mah] +is_a: GO:0007044 ! cell-substrate junction assembly +relationship: part_of GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0048045 +name: trans-pentaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate." [RHEA:22632] +synonym: "all-trans-hexaprenyl-diphosphate synthase activity" RELATED [] +synonym: "all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity" RELATED [] +synonym: "hexaprenyl diphosphate synthase activity" RELATED [] +synonym: "hexaprenyl pyrophosphate synthetase activity" EXACT [] +xref: KEGG_REACTION:R05613 +xref: RHEA:22632 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0048046 +name: apoplast +namespace: cellular_component +def: "The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it." [GOC:jid] +xref: Wikipedia:Apoplast +is_a: GO:0005576 ! extracellular region + +[Term] +id: GO:0048047 +name: mating behavior, sex discrimination +namespace: biological_process +def: "The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner." [GOC:jid, GOC:pr, PMID:12486700] +synonym: "mating behaviour, sex discrimination" EXACT [] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0048048 +name: embryonic eye morphogenesis +namespace: biological_process +def: "The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized." [GOC:jid] +is_a: GO:0048562 ! embryonic organ morphogenesis +is_a: GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0048050 +name: post-embryonic eye morphogenesis +namespace: biological_process +alt_id: GO:0048051 +def: "The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight." [GOC:jid, GOC:sensu] +is_a: GO:0048563 ! post-embryonic animal organ morphogenesis +is_a: GO:0048592 ! eye morphogenesis + +[Term] +id: GO:0048052 +name: R1/R6 cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048053 +name: R1/R6 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048052 ! R1/R6 cell differentiation + +[Term] +id: GO:0048054 +name: R2/R5 cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048055 +name: R2/R5 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048054 ! R2/R5 cell differentiation + +[Term] +id: GO:0048056 +name: R3/R4 cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0048057 +name: R3/R4 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster." [GOC:jid] +is_a: GO:0042051 ! compound eye photoreceptor development +relationship: part_of GO:0048056 ! R3/R4 cell differentiation + +[Term] +id: GO:0048058 +name: compound eye corneal lens development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells." [GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048749 ! compound eye development + +[Term] +id: GO:0048060 +name: negative gravitaxis +namespace: biological_process +alt_id: GO:0048063 +def: "The directed movement of a motile cell or organism away from the source of gravity." [GOC:jid] +synonym: "negative geotactic behavior" EXACT [] +synonym: "negative geotactic behaviour" EXACT [] +synonym: "negative gravitactic behavior" EXACT [] +synonym: "negative gravitactic behaviour" EXACT [] +synonym: "negative taxis in response to gravity" EXACT [] +synonym: "negative taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] +is_a: GO:0042332 ! gravitaxis + +[Term] +id: GO:0048061 +name: positive gravitaxis +namespace: biological_process +alt_id: GO:0048064 +def: "The directed movement of a motile cell or organism towards the source of gravity." [GOC:jid] +synonym: "positive geotactic behavior" EXACT [] +synonym: "positive geotactic behaviour" EXACT [] +synonym: "positive gravitactic behavior" EXACT [] +synonym: "positive gravitactic behaviour" EXACT [] +synonym: "positive taxis in response to gravity" EXACT [] +synonym: "positive taxis in response to gravitytaxis in response to gravitational stimulus" EXACT [] +is_a: GO:0042332 ! gravitaxis + +[Term] +id: GO:0048065 +name: male courtship behavior, veined wing extension +namespace: biological_process +def: "The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] +synonym: "male courtship behavior, wing extension" BROAD [] +synonym: "male courtship behaviour, veined wing extension" EXACT [] +synonym: "male courtship behaviour, wing extension" BROAD [] +is_a: GO:0008049 ! male courtship behavior + +[Term] +id: GO:0048066 +name: developmental pigmentation +namespace: biological_process +def: "The developmental process that results in the deposition of coloring matter in an organism, tissue or cell." [ISBN:0582227089] +synonym: "pigmentation during development" RELATED [] +is_a: GO:0043473 ! pigmentation + +[Term] +id: GO:0048067 +name: cuticle pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] +is_a: GO:0048066 ! developmental pigmentation +relationship: part_of GO:0042335 ! cuticle development + +[Term] +id: GO:0048069 +name: eye pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the eye of an organism." [GOC:jid] +xref: Wikipedia:Eye_color +is_a: GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0048070 +name: regulation of developmental pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] +synonym: "regulation of pigmentation during development" EXACT [GOC:dph, GOC:tb] +is_a: GO:0120305 ! regulation of pigmentation +relationship: regulates GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0048071 +name: sex-specific pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in one sex that is not observed in the other sex." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048066 ! developmental pigmentation +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0048072 +name: compound eye pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in the compound eye." [GOC:jid] +is_a: GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048073 +name: regulation of eye pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] +is_a: GO:0048070 ! regulation of developmental pigmentation +relationship: regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048074 +name: negative regulation of eye pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] +synonym: "down regulation of eye pigmentation" EXACT [] +synonym: "down-regulation of eye pigmentation" EXACT [] +synonym: "downregulation of eye pigmentation" EXACT [] +synonym: "inhibition of eye pigmentation" NARROW [] +is_a: GO:0048073 ! regulation of eye pigmentation +is_a: GO:0048086 ! negative regulation of developmental pigmentation +relationship: negatively_regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048075 +name: positive regulation of eye pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the eye of an organism." [GOC:jid] +synonym: "activation of eye pigmentation" NARROW [] +synonym: "stimulation of eye pigmentation" NARROW [] +synonym: "up regulation of eye pigmentation" EXACT [] +synonym: "up-regulation of eye pigmentation" EXACT [] +synonym: "upregulation of eye pigmentation" EXACT [] +is_a: GO:0048073 ! regulation of eye pigmentation +is_a: GO:0048087 ! positive regulation of developmental pigmentation +relationship: positively_regulates GO:0048069 ! eye pigmentation + +[Term] +id: GO:0048076 +name: regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] +is_a: GO:0048073 ! regulation of eye pigmentation +relationship: regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048077 +name: negative regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] +synonym: "down regulation of eye pigmentation" BROAD [] +synonym: "down-regulation of eye pigmentation" BROAD [] +synonym: "downregulation of eye pigmentation" BROAD [] +synonym: "inhibition of eye pigmentation" BROAD [] +synonym: "negative regulation of eye pigmentation" BROAD [] +is_a: GO:0048074 ! negative regulation of eye pigmentation +is_a: GO:0048076 ! regulation of compound eye pigmentation +relationship: negatively_regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048078 +name: positive regulation of compound eye pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the compound eye." [GOC:jid] +synonym: "activation of eye pigmentation" BROAD [] +synonym: "positive regulation of eye pigmentation" BROAD [] +synonym: "stimulation of eye pigmentation" BROAD [] +synonym: "up regulation of eye pigmentation" BROAD [] +synonym: "up-regulation of eye pigmentation" BROAD [] +synonym: "upregulation of eye pigmentation" BROAD [] +is_a: GO:0048075 ! positive regulation of eye pigmentation +is_a: GO:0048076 ! regulation of compound eye pigmentation +relationship: positively_regulates GO:0048072 ! compound eye pigmentation + +[Term] +id: GO:0048079 +name: regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] +is_a: GO:0048070 ! regulation of developmental pigmentation +relationship: regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048080 +name: negative regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] +synonym: "down regulation of cuticle pigmentation" EXACT [] +synonym: "down-regulation of cuticle pigmentation" EXACT [] +synonym: "downregulation of cuticle pigmentation" EXACT [] +synonym: "inhibition of cuticle pigmentation" NARROW [] +is_a: GO:0048079 ! regulation of cuticle pigmentation +is_a: GO:0048086 ! negative regulation of developmental pigmentation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048081 +name: positive regulation of cuticle pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism." [GOC:jid] +synonym: "activation of cuticle pigmentation" NARROW [] +synonym: "stimulation of cuticle pigmentation" NARROW [] +synonym: "up regulation of cuticle pigmentation" EXACT [] +synonym: "up-regulation of cuticle pigmentation" EXACT [] +synonym: "upregulation of cuticle pigmentation" EXACT [] +is_a: GO:0048079 ! regulation of cuticle pigmentation +is_a: GO:0048087 ! positive regulation of developmental pigmentation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0048067 ! cuticle pigmentation + +[Term] +id: GO:0048082 +name: regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] +is_a: GO:0048079 ! regulation of cuticle pigmentation +relationship: regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048083 +name: negative regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] +synonym: "down regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "down-regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "downregulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "inhibition of adult chitin-containing cuticle pigmentation" NARROW [] +is_a: GO:0045800 ! negative regulation of chitin-based cuticle tanning +is_a: GO:0048080 ! negative regulation of cuticle pigmentation +is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation +relationship: negatively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048084 +name: positive regulation of adult chitin-containing cuticle pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism." [GOC:jid, GOC:mtg_sensu] +synonym: "activation of adult chitin-containing cuticle pigmentation" NARROW [] +synonym: "stimulation of adult chitin-containing cuticle pigmentation" NARROW [] +synonym: "up regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "up-regulation of adult chitin-containing cuticle pigmentation" EXACT [] +synonym: "upregulation of adult chitin-containing cuticle pigmentation" EXACT [] +is_a: GO:0045801 ! positive regulation of chitin-based cuticle tanning +is_a: GO:0048081 ! positive regulation of cuticle pigmentation +is_a: GO:0048082 ! regulation of adult chitin-containing cuticle pigmentation +relationship: positively_regulates GO:0048085 ! adult chitin-containing cuticle pigmentation + +[Term] +id: GO:0048085 +name: adult chitin-containing cuticle pigmentation +namespace: biological_process +alt_id: GO:0048068 +def: "Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] +synonym: "adult cuticle pigmentation" BROAD [] +is_a: GO:0048067 ! cuticle pigmentation +relationship: part_of GO:0007593 ! chitin-based cuticle sclerotization + +[Term] +id: GO:0048086 +name: negative regulation of developmental pigmentation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] +synonym: "down regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] +synonym: "down-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] +synonym: "downregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of pigmentation" NARROW [] +is_a: GO:0048070 ! regulation of developmental pigmentation +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0048087 +name: positive regulation of developmental pigmentation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism." [GOC:dph, GOC:jid, GOC:tb] +synonym: "activation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] +synonym: "stimulation of developmental pigmentation" NARROW [GOC:dph, GOC:tb] +synonym: "up regulation of developmental pigmentation" EXACT [GOC:dph] +synonym: "up-regulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] +synonym: "upregulation of developmental pigmentation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048070 ! regulation of developmental pigmentation +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0048088 +name: regulation of male pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] +is_a: GO:0048070 ! regulation of developmental pigmentation +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048089 +name: regulation of female pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] +is_a: GO:0048070 ! regulation of developmental pigmentation +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048090 +name: negative regulation of female pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] +synonym: "down regulation of female pigmentation" EXACT [] +synonym: "down-regulation of female pigmentation" EXACT [] +synonym: "downregulation of female pigmentation" EXACT [] +synonym: "inhibition of female pigmentation" NARROW [] +is_a: GO:0048086 ! negative regulation of developmental pigmentation +is_a: GO:0048089 ! regulation of female pigmentation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048091 +name: positive regulation of female pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females." [GOC:jid] +synonym: "activation of female pigmentation" NARROW [] +synonym: "stimulation of female pigmentation" NARROW [] +synonym: "up regulation of female pigmentation" EXACT [] +synonym: "up-regulation of female pigmentation" EXACT [] +synonym: "upregulation of female pigmentation" EXACT [] +is_a: GO:0048087 ! positive regulation of developmental pigmentation +is_a: GO:0048089 ! regulation of female pigmentation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048095 ! female pigmentation + +[Term] +id: GO:0048092 +name: negative regulation of male pigmentation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] +synonym: "down regulation of male pigmentation" EXACT [] +synonym: "down-regulation of male pigmentation" EXACT [] +synonym: "downregulation of male pigmentation" EXACT [] +synonym: "inhibition of male pigmentation" NARROW [] +is_a: GO:0048086 ! negative regulation of developmental pigmentation +is_a: GO:0048088 ! regulation of male pigmentation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048093 +name: positive regulation of male pigmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males." [GOC:jid] +synonym: "activation of male pigmentation" NARROW [] +synonym: "stimulation of male pigmentation" NARROW [] +synonym: "up regulation of male pigmentation" EXACT [] +synonym: "up-regulation of male pigmentation" EXACT [] +synonym: "upregulation of male pigmentation" EXACT [] +is_a: GO:0048087 ! positive regulation of developmental pigmentation +is_a: GO:0048088 ! regulation of male pigmentation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048094 ! male pigmentation + +[Term] +id: GO:0048094 +name: male pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in males." [GOC:jid] +is_a: GO:0048071 ! sex-specific pigmentation +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0048095 +name: female pigmentation +namespace: biological_process +def: "Establishment of a pattern of pigment in females." [GOC:jid] +is_a: GO:0048071 ! sex-specific pigmentation +relationship: part_of GO:0046660 ! female sex differentiation + +[Term] +id: GO:0048097 +name: obsolete long-term maintenance of gene activation +namespace: biological_process +def: "OBSOLETE. Any mechanism, at the level of transcription or post-transcription, maintaining gene activation in the long-term." [GOC:jid] +comment: This term has been obsoleted because its definition was not clear, and had no references and no annotations. +is_obsolete: true +consider: GO:0045815 + +[Term] +id: GO:0048098 +name: antennal joint development +namespace: biological_process +def: "The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments." [GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007469 ! antennal development + +[Term] +id: GO:0048099 +name: anterior/posterior lineage restriction, imaginal disc +namespace: biological_process +def: "Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:jid, PMID:10625531, PMID:9374402] +is_a: GO:0035161 ! imaginal disc lineage restriction +relationship: part_of GO:0007448 ! anterior/posterior pattern specification, imaginal disc + +[Term] +id: GO:0048100 +name: wing disc anterior/posterior pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing." [GOC:jid, PMID:10625531] +is_a: GO:0007448 ! anterior/posterior pattern specification, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0048101 +name: calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive." [GOC:jid] +synonym: "calcium- and calmodulin-regulated cGMP phosphodiesterase activity" RELATED [] +synonym: "calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] +synonym: "calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity" EXACT [] +synonym: "calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity" EXACT [] +is_a: GO:0047555 ! 3',5'-cyclic-GMP phosphodiesterase activity + +[Term] +id: GO:0048102 +name: autophagic cell death +namespace: biological_process +def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] +comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. +synonym: "autophagic death" BROAD [] +synonym: "autosis" RELATED [PMID:25236395] +synonym: "programmed cell death by autophagy" BROAD [GOC:pr] +synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] +synonym: "type II programmed cell death" RELATED [GOC:sl] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0048103 +name: somatic stem cell division +namespace: biological_process +def: "The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line." [GOC:jid, ISBN:0582227089] +synonym: "somatic stem cell renewal" EXACT [] +is_a: GO:0017145 ! stem cell division + +[Term] +id: GO:0048104 +name: establishment of body hair or bristle planar orientation +namespace: biological_process +def: "Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] +is_a: GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0048105 +name: establishment of body hair planar orientation +namespace: biological_process +def: "Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] +is_a: GO:0048104 ! establishment of body hair or bristle planar orientation + +[Term] +id: GO:0048106 +name: establishment of thoracic bristle planar orientation +namespace: biological_process +def: "Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction." [FBbt:00004298, FBbt:00004408, GOC:ascb_2009, GOC:dph, GOC:jid, GOC:tb] +synonym: "establishment of body bristle planar orientation" EXACT [GOC:bf] +is_a: GO:0048104 ! establishment of body hair or bristle planar orientation +relationship: part_of GO:0008407 ! chaeta morphogenesis + +[Term] +id: GO:0048107 +name: 4-amino-3-isothiazolidinone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-amino-3-isothiazolinone, five-membered saturated heterocyclic ring structures containing a sulfur and a nitrogen in the 1-position and 2-positions respectively." [GOC:jid] +synonym: "4-amino-3-isothiazolidinone anabolism" EXACT [] +synonym: "4-amino-3-isothiazolidinone biosynthesis" EXACT [] +synonym: "4-amino-3-isothiazolidinone formation" EXACT [] +synonym: "4-amino-3-isothiazolidinone synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0048108 +name: peptide cross-linking via 4-amino-3-isothiazolidinone +namespace: biological_process +def: "The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue." [GOC:jid, GOC:jsg] +comment: Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link. +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0048109 +name: peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water." [GOC:jid, PMID:12802338, PMID:12802339, RESID:AA0344] +xref: RESID:AA0344 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0048108 ! peptide cross-linking via 4-amino-3-isothiazolidinone + +[Term] +id: GO:0048132 +name: female germ-line stem cell asymmetric division +namespace: biological_process +alt_id: GO:0048141 +def: "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes." [GOC:jid, GOC:mtg_sensu] +synonym: "female germ-line stem cell renewal" EXACT [] +is_a: GO:0098728 ! germline stem cell asymmetric division +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0048133 +name: male germ-line stem cell asymmetric division +namespace: biological_process +def: "The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes." [GOC:jid] +synonym: "male germ-line stem cell renewal" EXACT [] +is_a: GO:0098728 ! germline stem cell asymmetric division +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048134 +name: germ-line cyst formation +namespace: biological_process +def: "Formation of a group of interconnected cells derived from a single gonial founder cell." [GOC:jid, PMID:10370240, PMID:21681920] +synonym: "germline cyst formation" EXACT [PMID:10370240] +is_a: GO:0008283 ! cell population proliferation +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007281 ! germ cell development + +[Term] +id: GO:0048135 +name: female germ-line cyst formation +namespace: biological_process +def: "Formation of a group of interconnected cells derived from a single female gonial founder cell." [GOC:jid, PMID:10370240] +synonym: "female germline cyst formation" EXACT [PMID:10370240] +is_a: GO:0048134 ! germ-line cyst formation +relationship: part_of GO:0048477 ! oogenesis + +[Term] +id: GO:0048136 +name: male germ-line cyst formation +namespace: biological_process +def: "Formation of a group of interconnected cells derived from a single male gonial founder cell." [GOC:jid, PMID:10370240] +synonym: "male germline cyst formation" EXACT [PMID:10370240] +is_a: GO:0048134 ! germ-line cyst formation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048137 +name: spermatocyte division +namespace: biological_process +def: "The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids." [GOC:jid, GOC:pr, ISBN:0879694238] +synonym: "spermatocyte cell division" EXACT [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051301 ! cell division +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048138 +name: germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007276 ! gamete generation +relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium + +[Term] +id: GO:0048139 +name: female germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad." [GOC:jid] +is_a: GO:0048138 ! germ-line cyst encapsulation +relationship: part_of GO:0007292 ! female gamete generation + +[Term] +id: GO:0048140 +name: male germ-line cyst encapsulation +namespace: biological_process +def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad." [GOC:jid, PMID:11591336] +is_a: GO:0048138 ! germ-line cyst encapsulation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048142 +name: germarium-derived cystoblast division +namespace: biological_process +def: "The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu, PMID:11131529] +synonym: "germarium-derived cystoblast cell division" EXACT [] +is_a: GO:0007282 ! cystoblast division +relationship: part_of GO:0030727 ! germarium-derived female germ-line cyst formation + +[Term] +id: GO:0048143 +name: astrocyte activation +namespace: biological_process +def: "A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10526094, PMID:10695728, PMID:12529254, PMID:12580336, PMID:9585813] +is_a: GO:0061900 ! glial cell activation +relationship: part_of GO:0014002 ! astrocyte development + +[Term] +id: GO:0048144 +name: fibroblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." [GOC:jid] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0048145 +name: regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048146 +name: positive regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] +synonym: "activation of fibroblast proliferation" NARROW [] +synonym: "stimulation of fibroblast proliferation" NARROW [] +synonym: "up regulation of fibroblast proliferation" EXACT [] +synonym: "up-regulation of fibroblast proliferation" EXACT [] +synonym: "upregulation of fibroblast proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: positively_regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048147 +name: negative regulation of fibroblast proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells." [GOC:jid] +synonym: "down regulation of fibroblast proliferation" EXACT [] +synonym: "down-regulation of fibroblast proliferation" EXACT [] +synonym: "downregulation of fibroblast proliferation" EXACT [] +synonym: "inhibition of fibroblast proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: negatively_regulates GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0048148 +name: behavioral response to cocaine +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus." [GOC:jid] +synonym: "behavioural response to cocaine" EXACT [] +is_a: GO:0030534 ! adult behavior +relationship: part_of GO:0042220 ! response to cocaine + +[Term] +id: GO:0048149 +name: behavioral response to ethanol +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus." [GOC:jid] +synonym: "behavioural response to ethanol" EXACT [] +is_a: GO:0030534 ! adult behavior +relationship: part_of GO:0045471 ! response to ethanol + +[Term] +id: GO:0048150 +name: behavioral response to ether +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of an ether stimulus." [GOC:jid] +synonym: "behavioural response to ether" EXACT [] +is_a: GO:0030534 ! adult behavior +relationship: part_of GO:0045472 ! response to ether + +[Term] +id: GO:0048151 +name: obsolete hyperphosphorylation +namespace: biological_process +def: "OBSOLETE. The excessive phosphorylation of a protein, as a result of activation of kinases, deactivation of phosphatases, or both." [GOC:jid, ISBN:039751820X, PMID:12859672] +comment: This term was made obsolete because it is an unnecessary grouping term and was poorly defined. +synonym: "hyperphosphorylation" EXACT [] +is_obsolete: true +replaced_by: GO:0016310 + +[Term] +id: GO:0048152 +name: obsolete S100 beta biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 beta protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "S100 beta anabolism" EXACT [] +synonym: "S100 beta biosynthesis" EXACT [] +synonym: "S100 beta formation" EXACT [] +synonym: "S100 beta synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048153 +name: obsolete S100 alpha biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of S100 alpha protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] +comment: The reason for obsoletion is that those represent specific gene products, and genes annotated to those terms should be annotated to 'regulation of gene expression' or 'regulation of transcription' or some signaling term. +synonym: "S100 alpha anabolism" EXACT [] +synonym: "S100 alpha biosynthesis" EXACT [] +synonym: "S100 alpha formation" EXACT [] +synonym: "S100 alpha synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048156 +name: tau protein binding +namespace: molecular_function +def: "Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0048158 +name: oogonium stage +namespace: biological_process +def: "The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 1" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048159 +name: primary oocyte stage +namespace: biological_process +def: "The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 2" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048160 +name: primary follicle stage +namespace: biological_process +def: "The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 3" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048161 +name: double layer follicle stage +namespace: biological_process +def: "The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 4" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048162 +name: multi-layer follicle stage +namespace: biological_process +def: "The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 5" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048163 +name: scattered antral spaces stage +namespace: biological_process +def: "The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 6" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048164 +name: distinct antral spaces stage +namespace: biological_process +def: "The stage in oogenesis when the antral spaces become distinct and the first polar body forms." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 7" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048165 +name: fused antrum stage +namespace: biological_process +def: "The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 8" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048166 +name: mature follicle stage +namespace: biological_process +def: "The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division." [GOC:jid, GOC:mtg_sensu, ISBN:0198542771] +synonym: "mammalian oogenesis stage 9" EXACT [] +is_a: GO:0022605 ! mammalian oogenesis stage + +[Term] +id: GO:0048167 +name: regulation of synaptic plasticity +namespace: biological_process +def: "A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:dph, GOC:jid, GOC:tb, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0048168 +name: regulation of neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0048169 +name: regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0048170 +name: positive regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "activation of long-term neuronal synaptic plasticity" NARROW [] +synonym: "stimulation of long-term neuronal synaptic plasticity" NARROW [] +synonym: "up regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "up-regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "upregulation of long-term neuronal synaptic plasticity" EXACT [] +is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity +is_a: GO:0050769 ! positive regulation of neurogenesis + +[Term] +id: GO:0048171 +name: negative regulation of long-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "down regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "down-regulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "downregulation of long-term neuronal synaptic plasticity" EXACT [] +synonym: "inhibition of long-term neuronal synaptic plasticity" NARROW [] +is_a: GO:0048169 ! regulation of long-term neuronal synaptic plasticity +is_a: GO:0050768 ! negative regulation of neurogenesis + +[Term] +id: GO:0048172 +name: regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +is_a: GO:0048168 ! regulation of neuronal synaptic plasticity + +[Term] +id: GO:0048173 +name: positive regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "activation of short-term neuronal synaptic plasticity" NARROW [] +synonym: "stimulation of short-term neuronal synaptic plasticity" NARROW [] +synonym: "up regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "up-regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "upregulation of short-term neuronal synaptic plasticity" EXACT [] +is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity +is_a: GO:0050769 ! positive regulation of neurogenesis + +[Term] +id: GO:0048174 +name: negative regulation of short-term neuronal synaptic plasticity +namespace: biological_process +def: "A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity." [GOC:jid, PMID:11891290] +comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. +synonym: "down regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "down-regulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "downregulation of short-term neuronal synaptic plasticity" EXACT [] +synonym: "inhibition of short-term neuronal synaptic plasticity" NARROW [] +is_a: GO:0048172 ! regulation of short-term neuronal synaptic plasticity +is_a: GO:0050768 ! negative regulation of neurogenesis + +[Term] +id: GO:0048179 +name: activin receptor complex +namespace: cellular_component +def: "A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed." [PMID:8307945, PMID:8622651] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +is_a: GO:1902554 ! serine/threonine protein kinase complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0048180 +name: activin complex +namespace: cellular_component +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +subset: goslim_pir +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0048183 +name: activin AB complex +namespace: cellular_component +def: "A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B." [GOC:go_curators] +comment: Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. +synonym: "inhibin beta-A" NARROW [] +synonym: "inhibin beta-B" NARROW [] +is_a: GO:0048180 ! activin complex + +[Term] +id: GO:0048184 +name: obsolete follistatin binding +namespace: molecular_function +def: "OBSOLETE. Binding to the peptide hormone follistatin." [GOC:jid, GOC:mah] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "follistatin binding" EXACT [] +is_obsolete: true +replaced_by: GO:0017046 + +[Term] +id: GO:0048185 +name: activin binding +namespace: molecular_function +def: "Binding to activin, a dimer of inhibin-beta subunits." [GOC:jid, GOC:mah] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0048188 +name: Set1C/COMPASS complex +namespace: cellular_component +def: "A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30." [PMID:11687631, PMID:11742990, PMID:11805083, PMID:12488447, PMID:18508253, PMID:18838538] +synonym: "COMPASS complex" EXACT [GOC:vw] +synonym: "Set1/COMPASS complex" EXACT [GOC:mah] +synonym: "Set1C" EXACT [GOC:vw] +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0048189 +name: Lid2 complex +namespace: cellular_component +def: "A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1." [PMID:12488447] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0048190 +name: wing disc dorsal/ventral pattern formation +namespace: biological_process +def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing." [GOC:jid] +synonym: "wing disc dorsal-ventral pattern formation" EXACT [GOC:mah] +synonym: "wing disc dorsoventral pattern formation" EXACT [GOC:mah] +is_a: GO:0007450 ! dorsal/ventral pattern formation, imaginal disc +is_a: GO:0035222 ! wing disc pattern formation + +[Term] +id: GO:0048191 +name: obsolete peptide stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond between peptides. Peptides are compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jid] +comment: This term was made obsolete because it represents a biological process. +synonym: "peptide stabilization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0050822 + +[Term] +id: GO:0048192 +name: obsolete peptide antigen stabilization activity +namespace: molecular_function +def: "OBSOLETE. Strengthening of a bond with a peptide antigen; a fragment of a foreign protein derived by proteolysis within the cell." [GOC:jid] +comment: This term was made obsolete because it represents a biological process. +synonym: "peptide antigen stabilization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0050823 + +[Term] +id: GO:0048193 +name: Golgi vesicle transport +namespace: biological_process +def: "The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles." [GOC:jid, ISBN:0716731363, PMID:10219233] +subset: goslim_yeast +synonym: "Golgi-derived vesicle transport" RELATED [] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0048194 +name: Golgi vesicle budding +namespace: biological_process +def: "The evagination of the Golgi membrane, resulting in formation of a vesicle." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle budding" NARROW [] +synonym: "Golgi-derived vesicle budding" EXACT [] +is_a: GO:0006900 ! vesicle budding from membrane +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048195 +name: Golgi membrane priming complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "formation of dictyosome membrane priming complex" NARROW [] +synonym: "formation of Golgi membrane priming complex" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0048200 ! Golgi transport vesicle coating + +[Term] +id: GO:0048196 +name: obsolete plant extracellular matrix +namespace: cellular_component +def: "OBSOLETE. The matrix external to the plant plasma membrane, composed of the cell wall and middle lamella." [GOC:jid, GOC:mtg_sensu, PMID:11351084, PMID:4327466] +comment: Note that this term does not have 'extracellular region ; GO:0005576' as a parent because in plants the extracellular matrix is considered part of the cell. +synonym: "middle lamella-containing extracellular matrix" RELATED [GOC:tb] +synonym: "plant extracellular matrix" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048197 +name: Golgi membrane coat protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome membrane binding by cytosolic coat proteins" NARROW [] +synonym: "dictyosome membrane bud coat oligomerisation" NARROW [] +synonym: "Golgi membrane bud coat oligomerisation" NARROW [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0048200 ! Golgi transport vesicle coating + +[Term] +id: GO:0048198 +name: Golgi vesicle bud deformation and release +namespace: biological_process +def: "The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle bud deformation" NARROW [] +synonym: "Golgi-derived vesicle bud deformation and release" EXACT [] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0048194 ! Golgi vesicle budding + +[Term] +id: GO:0048199 +name: vesicle targeting, to, from or within Golgi +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle targeting" NARROW [] +synonym: "Golgi vesicle targeting" EXACT [] +synonym: "vesicle targeting, to, from or within dictyosome" NARROW [] +is_a: GO:0006903 ! vesicle targeting +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048200 +name: Golgi transport vesicle coating +namespace: biological_process +def: "The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome transport vesicle coating" NARROW [] +is_a: GO:0006901 ! vesicle coating +relationship: part_of GO:0048194 ! Golgi vesicle budding +relationship: part_of GO:0048199 ! vesicle targeting, to, from or within Golgi + +[Term] +id: GO:0048201 +name: vesicle targeting, plasma membrane to endosome +namespace: biological_process +def: "The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "plasma membrane to endosome targeting" EXACT [] +is_a: GO:0006903 ! vesicle targeting + +[Term] +id: GO:0048202 +name: clathrin coating of Golgi vesicle +namespace: biological_process +def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "clathrin coating of Golgi-derived vesicle" EXACT [] +is_a: GO:0048200 ! Golgi transport vesicle coating +is_a: GO:0048268 ! clathrin coat assembly + +[Term] +id: GO:0048203 +name: vesicle targeting, trans-Golgi to endosome +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "trans-Golgi to endosome targeting" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0006895 ! Golgi to endosome transport + +[Term] +id: GO:0048204 +name: vesicle targeting, inter-Golgi cisterna +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "inter-Golgi cisterna targeting" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport + +[Term] +id: GO:0048205 +name: COPI coating of Golgi vesicle +namespace: biological_process +def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "COPI coating of Golgi-derived vesicle" EXACT [] +synonym: "COPI vesicle coating" RELATED [GOC:br] +is_a: GO:0048200 ! Golgi transport vesicle coating +relationship: part_of GO:0035964 ! COPI-coated vesicle budding + +[Term] +id: GO:0048206 +name: vesicle targeting, cis-Golgi to rough endoplasmic reticulum +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "cis-Golgi to rough endoplasmic reticulum targeting" EXACT [] +synonym: "cis-Golgi to rough ER targeting" EXACT [] +synonym: "vesicle targeting, cis-Golgi to rough ER" EXACT [] +is_a: GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +is_a: GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:0048207 +name: vesicle targeting, rough ER to cis-Golgi +namespace: biological_process +def: "The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "rough endoplasmic reticulum to cis-Golgi targeting" EXACT [] +synonym: "rough ER to cis-Golgi targeting" EXACT [] +synonym: "vesicle targeting, rough endoplasmic reticulum to cis-Golgi" EXACT [] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:0048208 +name: COPII vesicle coating +namespace: biological_process +def: "The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jid, GOC:mah, GOC:tb, ISBN:0716731363, PMID:10219233] +synonym: "COPII coating of ER-derived vesicle" EXACT [GOC:tb] +synonym: "COPII vesicle coat assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "COPII vesicle coat formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0006901 ! vesicle coating +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0048207 ! vesicle targeting, rough ER to cis-Golgi +relationship: part_of GO:0090114 ! COPII-coated vesicle budding + +[Term] +id: GO:0048209 +name: regulation of vesicle targeting, to, from or within Golgi +namespace: biological_process +def: "Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "regulation of Golgi vesicle targeting" EXACT [] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0048199 ! vesicle targeting, to, from or within Golgi + +[Term] +id: GO:0048210 +name: Golgi vesicle fusion to target membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle fusion to target membrane" NARROW [] +synonym: "Golgi-derived vesicle fusion to target membrane" EXACT [] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048211 +name: Golgi vesicle docking +namespace: biological_process +def: "The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle docking to target membrane" NARROW [] +synonym: "Golgi vesicle docking with target membrane" EXACT [] +synonym: "Golgi vesicle to membrane docking" EXACT [] +synonym: "Golgi-derived vesicle docking" EXACT [] +is_a: GO:0048278 ! vesicle docking +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048212 +name: Golgi vesicle uncoating +namespace: biological_process +def: "The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle coat depolymerization" NARROW [] +synonym: "Golgi vesicle coat depolymerization" EXACT [] +synonym: "Golgi vesicle coat protein depolymerization" EXACT [] +synonym: "Golgi-derived vesicle uncoating" EXACT [] +is_a: GO:0072319 ! vesicle uncoating +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048213 +name: Golgi vesicle prefusion complex stabilization +namespace: biological_process +def: "The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "dictyosome vesicle prefusion complex stabilisation" NARROW [] +synonym: "Golgi vesicle prefusion complex assembly" EXACT [] +synonym: "Golgi-derived vesicle prefusion complex stabilization" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048214 +name: regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] +comment: Note that GTP-binding Rab proteins serve as regulators of vesicle targeting and fusion. +is_a: GO:0031338 ! regulation of vesicle fusion +relationship: regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048215 +name: positive regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "activation of Golgi vesicle fusion to target membrane" NARROW [] +synonym: "stimulation of Golgi vesicle fusion to target membrane" NARROW [] +synonym: "up regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "up-regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "upregulation of Golgi vesicle fusion to target membrane" EXACT [] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane +relationship: positively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048216 +name: negative regulation of Golgi vesicle fusion to target membrane +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Golgi vesicle fusion to target membrane." [GOC:jid, ISBN:0716731363, PMID:10219233] +synonym: "down regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "down-regulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "downregulation of Golgi vesicle fusion to target membrane" EXACT [] +synonym: "inhibition of Golgi vesicle fusion to target membrane" NARROW [] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0048214 ! regulation of Golgi vesicle fusion to target membrane +relationship: negatively_regulates GO:0048210 ! Golgi vesicle fusion to target membrane + +[Term] +id: GO:0048217 +name: pectic matrix +namespace: cellular_component +def: "The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls." [GOC:jid, PMID:11554482] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009530 ! primary cell wall +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048219 +name: inter-Golgi cisterna vesicle-mediated transport +namespace: biological_process +def: "The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles." [GOC:jid, GOC:mah, ISBN:0716731363, PMID:10219233] +synonym: "inter-Golgi cisterna transport" EXACT [] +is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport + +[Term] +id: GO:0048222 +name: glycoprotein network +namespace: cellular_component +def: "An extracellular matrix part that consists of cross-linked glycoproteins." [GOC:mah, PMID:18508691, PMID:7048321] +synonym: "extensin" EXACT [] +xref: Wikipedia:Extensin +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009530 ! primary cell wall + +[Term] +id: GO:0048223 +name: hemicellulose network +namespace: cellular_component +def: "Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan." [DOI:10.1016/j.foodchem.2008.11.065, GOC:jid] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009530 ! primary cell wall +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048224 +name: lignin network +namespace: cellular_component +def: "An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens." [GOC:jid, GOC:mah, PMID:14503002, PMID:16662709] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048225 +name: suberin network +namespace: cellular_component +def: "An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier." [GOC:jid, GOC:mah, PMID:18440267, PMID:7706282] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048226 +name: Casparian strip +namespace: cellular_component +def: "Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants." [GOC:jid] +xref: Wikipedia:Casparian_strip +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009531 ! secondary cell wall + +[Term] +id: GO:0048227 +name: plasma membrane to endosome transport +namespace: biological_process +def: "Transport of a vesicle from the plasma membrane to the endosome." [GOC:jid] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0048228 +name: obsolete actin cortical patch distribution +namespace: biological_process +def: "OBSOLETE. Any process that establishes the spatial arrangement of actin cortical patches. An actin cortical patch is a discrete actin-containing structure found at the plasma membrane in fungal cells." [GOC:jid] +comment: This term was made obsolete because its definition is very similar to that of its parent term, actin cortical patch localization (GO:0051666), but somewhat unclear, and not similar enough to merge the terms. +synonym: "actin cortical patch distribution" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048229 +name: gametophyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana." [GOC:jid, PO:0009004] +synonym: "gametogenesis" BROAD [] +is_a: GO:0007275 ! multicellular organism development + +[Term] +id: GO:0048232 +name: male gamete generation +namespace: biological_process +def: "Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction." [GOC:dph, GOC:jid] +is_a: GO:0007276 ! gamete generation + +[Term] +id: GO:0048235 +name: pollen sperm cell differentiation +namespace: biological_process +alt_id: GO:0048234 +def: "The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte." [CL:0000366, GOC:jid, GOC:mtg_sensu] +synonym: "male gamete generation" BROAD [] +synonym: "male gametophyte sperm cell differentiation" EXACT [] +synonym: "sperm cell differentiation" BROAD [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048232 ! male gamete generation +relationship: part_of GO:0055046 ! microgametogenesis + +[Term] +id: GO:0048236 +name: plant-type sporogenesis +namespace: biological_process +def: "The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes." [GOC:tb] +synonym: "plant spore formation" EXACT [] +is_a: GO:0034293 ! sexual sporulation +is_a: GO:0048869 ! cellular developmental process +is_a: GO:0051321 ! meiotic cell cycle +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0048237 +name: rough endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the rough endoplasmic reticulum." [GOC:jid] +synonym: "RER lumen" EXACT [] +synonym: "rough ER lumen" EXACT [] +xref: NIF_Subcellular:sao1819509473 +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0005791 ! rough endoplasmic reticulum + +[Term] +id: GO:0048238 +name: smooth endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the smooth endoplasmic reticulum." [GOC:jid] +synonym: "SER lumen" EXACT [] +synonym: "smooth ER lumen" EXACT [] +xref: NIF_Subcellular:sao927884761 +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum + +[Term] +id: GO:0048239 +name: negative regulation of DNA recombination at telomere +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere." [GOC:jid, PMID:9635193] +synonym: "down regulation of telomeric recombination at telomere" EXACT [] +synonym: "down-regulation of telomeric recombination at telomere" EXACT [] +synonym: "downregulation of telomeric recombination at telomere" EXACT [] +synonym: "inhibition of telomeric recombination at telomere" NARROW [] +synonym: "negative regulation of telomeric recombination at telomere" EXACT [GOC:tb] +synonym: "suppression of telomeric recombination at telomere" EXACT [] +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:0072695 ! regulation of DNA recombination at telomere + +[Term] +id: GO:0048240 +name: sperm capacitation +namespace: biological_process +def: "A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium." [GOC:jid, ISBN:978-3-642-58301-8, PMID:11820818] +comment: Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract. +synonym: "sperm activation" RELATED [PMID:23180860] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:0048241 +name: epinephrine transport +namespace: biological_process +def: "The directed movement of epinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jid] +synonym: "adrenaline transport" EXACT [] +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0048242 +name: epinephrine secretion +namespace: biological_process +def: "The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system." [GOC:ef, GOC:jid] +synonym: "adrenaline secretion" EXACT [] +is_a: GO:0048241 ! epinephrine transport +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0048243 +name: norepinephrine secretion +namespace: biological_process +def: "The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system." [GOC:ef, GOC:jid] +synonym: "noradrenaline secretion" EXACT [] +is_a: GO:0015874 ! norepinephrine transport +is_a: GO:0023061 ! signal release +is_a: GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0048244 +name: phytanoyl-CoA dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate." [EC:1.14.11.18, RHEA:16065] +synonym: "phytanoyl-CoA 2 oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.18] +synonym: "phytanoyl-CoA 2-hydroxylase activity" RELATED [EC:1.14.11.18] +synonym: "phytanoyl-CoA alpha-hydroxylase activity" RELATED [EC:1.14.11.18] +synonym: "phytanoyl-CoA hydroxylase activity" RELATED [EC:1.14.11.18] +synonym: "phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.11.18] +xref: EC:1.14.11.18 +xref: KEGG_REACTION:R05722 +xref: MetaCyc:1.14.11.18-RXN +xref: Reactome:R-HSA-389639 "phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2" +xref: RHEA:16065 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0048245 +name: eosinophil chemotaxis +namespace: biological_process +def: "The movement of an eosinophil in response to an external stimulus." [GOC:jid, PMID:11292027, PMID:12391252] +is_a: GO:0071621 ! granulocyte chemotaxis +is_a: GO:0072677 ! eosinophil migration + +[Term] +id: GO:0048246 +name: macrophage chemotaxis +namespace: biological_process +def: "The movement of a macrophage in response to an external stimulus." [GOC:jid] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:1905517 ! macrophage migration + +[Term] +id: GO:0048247 +name: lymphocyte chemotaxis +namespace: biological_process +def: "The directed movement of a lymphocyte in response to an external stimulus." [GOC:hjd, GOC:jid, PMID:12391252] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:0072676 ! lymphocyte migration + +[Term] +id: GO:0048248 +name: CXCR3 chemokine receptor binding +namespace: molecular_function +def: "Binding to a CXCR3 chemokine receptor." [GOC:jid, PMID:10556837] +is_a: GO:0045236 ! CXCR chemokine receptor binding + +[Term] +id: GO:0048249 +name: high-affinity phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jid, PMID:8709965] +synonym: "high affinity phosphate transmembrane transporter activity" EXACT [] +is_a: GO:0015114 ! phosphate ion transmembrane transporter activity + +[Term] +id: GO:0048250 +name: iron import into the mitochondrion +namespace: biological_process +alt_id: GO:1990925 +def: "The process in which iron is transported from the cytosol into the mitochondrial matrix." [GOC:jid, PMID:12006577] +synonym: "mitochondrial iron cation transmembrane transport" EXACT [] +synonym: "mitochondrial iron ion transmembrane transport" RELATED [] +synonym: "mitochondrial iron ion transport" RELATED [] +synonym: "mitochondrial iron transport" EXACT [] +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0048251 +name: elastic fiber assembly +namespace: biological_process +def: "Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching." [GOC:jid, PMID:10841810, PMID:12615674] +synonym: "elastic fibre assembly" EXACT [] +synonym: "elastin fiber assembly" EXACT [GOC:BHF] +synonym: "elastin fibre assembly" EXACT [GOC:BHF] +is_a: GO:0085029 ! extracellular matrix assembly +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:0048252 +name: lauric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lauric acid, a fatty acid with the formula CH3(CH2)10COOH. Derived from vegetable sources." [GOC:jid, PMID:15555597] +synonym: "lauric acid metabolism" EXACT [] +synonym: "n-dodecanoic acid metabolic process" EXACT [] +synonym: "n-dodecanoic acid metabolism" EXACT [] +is_a: GO:0051791 ! medium-chain fatty acid metabolic process + +[Term] +id: GO:0048254 +name: snoRNA localization +namespace: biological_process +def: "Any process in which small nucleolar RNA is transported to, or maintained in, a specific location." [ISBN:0716731363] +synonym: "establishment and maintenance of snoRNA localization" EXACT [] +synonym: "small nucleolar RNA localization" EXACT [] +synonym: "snoRNA localisation" EXACT [GOC:mah] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0048255 +name: mRNA stabilization +namespace: biological_process +def: "Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules." [GOC:jid] +is_a: GO:0043488 ! regulation of mRNA stability +is_a: GO:0043489 ! RNA stabilization +is_a: GO:1902373 ! negative regulation of mRNA catabolic process + +[Term] +id: GO:0048256 +name: flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:0048257 +name: 3'-flap endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis." [GOC:jid, PMID:10635319] +synonym: "3' flap endonuclease activity" EXACT [] +is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters +is_a: GO:0048256 ! flap endonuclease activity + +[Term] +id: GO:0048258 +name: 3-ketoglucose-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose." [MetaCyc:KETOGLUCOSE-REDUCTASE-RXN] +xref: MetaCyc:KETOGLUCOSE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0048259 +name: regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] +synonym: "regulation of receptor mediated endocytosis" EXACT [GOC:tb] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048260 +name: positive regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators, GOC:tb] +synonym: "activation of receptor mediated endocytosis" NARROW [] +synonym: "positive regulation of receptor mediated endocytosis" EXACT [GOC:tb] +synonym: "stimulation of receptor mediated endocytosis" NARROW [] +synonym: "up regulation of receptor mediated endocytosis" EXACT [] +synonym: "up-regulation of receptor mediated endocytosis" EXACT [] +synonym: "upregulation of receptor mediated endocytosis" EXACT [] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: positively_regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048261 +name: negative regulation of receptor-mediated endocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." [GOC:go_curators] +synonym: "down regulation of receptor mediated endocytosis" EXACT [] +synonym: "down-regulation of receptor mediated endocytosis" EXACT [] +synonym: "downregulation of receptor mediated endocytosis" EXACT [] +synonym: "inhibition of receptor mediated endocytosis" NARROW [] +synonym: "negative regulation of receptor mediated endocytosis" EXACT [] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: negatively_regulates GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0048262 +name: determination of dorsal/ventral asymmetry +namespace: biological_process +def: "Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis." [GOC:jid] +synonym: "determination of adaxial/abaxial asymmetry" RELATED [GOC:dph, GOC:tb] +synonym: "determination of dorsal-ventral asymmetry" EXACT [GOC:mah] +synonym: "determination of dorsoventral asymmetry" EXACT [GOC:mah] +is_a: GO:0009855 ! determination of bilateral symmetry +relationship: part_of GO:0009953 ! dorsal/ventral pattern formation + +[Term] +id: GO:0048263 +name: determination of dorsal identity +namespace: biological_process +def: "Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:jid] +synonym: "determination of adaxial identity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry + +[Term] +id: GO:0048264 +name: determination of ventral identity +namespace: biological_process +def: "The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph, GOC:isa_complete, GOC:jid] +synonym: "determination of abaxial identity" EXACT [] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0048262 ! determination of dorsal/ventral asymmetry + +[Term] +id: GO:0048265 +name: response to pain +namespace: biological_process +alt_id: GO:0048267 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain] +synonym: "physiological response to pain" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0048266 +name: behavioral response to pain +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli." [GOC:jid] +synonym: "behavioural response to pain" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0048265 ! response to pain + +[Term] +id: GO:0048268 +name: clathrin coat assembly +namespace: biological_process +def: "The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage." [GOC:jid, PMID:11460887, PMID:11977118, PMID:9531549] +synonym: "clathrin cage assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0048269 +name: methionine adenosyltransferase complex +namespace: cellular_component +def: "A multimeric enzyme complex composed of variable numbers of catalytic alpha subunits, and noncatalytic beta subunits. The beta subunits are believed to have a regulatory function. The enzyme complex catalyzes the synthesis of S-adenosylmethionine (AdoMet), which is the major methyl group donor, participating in the methylation of proteins, DNA, RNA, phospholipids, and other small molecules." [EC:2.5.1.6, GOC:jid, PMID:10644686] +synonym: "MAT complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0048270 +name: methionine adenosyltransferase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of methionine adenosyltransferase." [GOC:jid, PMID:10644686] +comment: See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. +synonym: "MAT regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0048273 +name: mitogen-activated protein kinase p38 binding +namespace: molecular_function +def: "Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation." [GOC:curators, PMID:17827184] +synonym: "MAPK p38 binding" EXACT [] +is_a: GO:0051019 ! mitogen-activated protein kinase binding + +[Term] +id: GO:0048275 +name: N-terminal peptidyl-arginine acetylation +namespace: biological_process +def: "The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase." [GOC:jsg, PMID:12883043, RESID:AA0354] +xref: RESID:AA0354 +is_a: GO:0006474 ! N-terminal protein amino acid acetylation +is_a: GO:0018195 ! peptidyl-arginine modification + +[Term] +id: GO:0048277 +name: obsolete nonexocytotic vesicle docking +namespace: biological_process +def: "OBSOLETE. The initial attachment of a transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, during a non-exocytotic process." [GOC:jid] +comment: This term was made obsolete because it violates the principle of positivity. +synonym: "non-exocytotic vesicle docking" EXACT [] +synonym: "nonexocytotic vesicle docking" EXACT [] +is_obsolete: true +replaced_by: GO:0048278 + +[Term] +id: GO:0048278 +name: vesicle docking +namespace: biological_process +def: "The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:ai, GOC:jid] +synonym: "vesicle to membrane docking" EXACT [] +is_a: GO:0140056 ! organelle localization by membrane tethering +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0048279 +name: vesicle fusion with endoplasmic reticulum +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum." [GOC:jid] +synonym: "vesicle fusion with ER" EXACT [] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0048280 +name: vesicle fusion with Golgi apparatus +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi." [GOC:jid] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0007030 ! Golgi organization +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0048281 +name: inflorescence morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010016 ! shoot system morphogenesis +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0010229 ! inflorescence development + +[Term] +id: GO:0048282 +name: determinate inflorescence morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems." [GOC:jid, PMID:9553044] +is_a: GO:0048281 ! inflorescence morphogenesis + +[Term] +id: GO:0048283 +name: indeterminate inflorescence morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems." [GOC:jid] +is_a: GO:0048281 ! inflorescence morphogenesis + +[Term] +id: GO:0048284 +name: organelle fusion +namespace: biological_process +def: "The creation of a single organelle from two or more organelles." [GOC:jid] +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048285 +name: organelle fission +namespace: biological_process +def: "The creation of two or more organelles by division of one organelle." [GOC:jid] +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048286 +name: lung alveolus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways." [GOC:mtg_lung, PMID:9751757] +synonym: "alveolarization" EXACT [PMID:17911382] +synonym: "alveologenesis" EXACT [GOC:17911382] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0048288 +name: nuclear membrane fusion involved in karyogamy +namespace: biological_process +def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei." [GOC:jid] +synonym: "nuclear membrane fusion during karyogamy" RELATED [GOC:dph, GOC:tb] +is_a: GO:0000740 ! nuclear membrane fusion +relationship: part_of GO:0000741 ! karyogamy + +[Term] +id: GO:0048289 +name: isotype switching to IgE isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switch recombination to IgE isotypes" EXACT [] +synonym: "class switching to IgE isotypes" EXACT [] +synonym: "isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048290 +name: isotype switching to IgA isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switching to IgA isotypes" EXACT [] +synonym: "isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048291 +name: isotype switching to IgG isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] +synonym: "class switching to IgG isotypes" EXACT [] +synonym: "isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048292 +name: isotype switching to IgD isotypes +namespace: biological_process +def: "The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus." [ISBN:0781735149, PMID:12370374, PMID:2113175, PMID:9186655] +comment: Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms. +synonym: "class switching to IgD isotypes" EXACT [] +synonym: "isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045190 ! isotype switching + +[Term] +id: GO:0048293 +name: regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] +synonym: "regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "regulation of class switching to IgE isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048294 +name: negative regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] +synonym: "down regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgE isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgE isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "negative regulation of class switching to IgE isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgE isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes +relationship: negatively_regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048295 +name: positive regulation of isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgE isotypes." [GOC:jid] +synonym: "activation of isotype switching to IgE isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgE isotypes" EXACT [] +synonym: "positive regulation of class switching to IgE isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgE isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgE isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgE isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgE isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes +relationship: positively_regulates GO:0048289 ! isotype switching to IgE isotypes + +[Term] +id: GO:0048296 +name: regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] +synonym: "regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "regulation of class switching to IgA isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048297 +name: negative regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] +synonym: "down regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgA isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgA isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "negative regulation of class switching to IgA isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgA isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes +relationship: negatively_regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048298 +name: positive regulation of isotype switching to IgA isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgA isotypes." [GOC:jid] +synonym: "activation of isotype switching to IgA isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgA isotypes" EXACT [] +synonym: "positive regulation of class switching to IgA isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgA isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgA isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgA isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgA isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048296 ! regulation of isotype switching to IgA isotypes +relationship: positively_regulates GO:0048290 ! isotype switching to IgA isotypes + +[Term] +id: GO:0048299 +name: regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] +synonym: "regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "regulation of class switching to IgD isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048300 +name: negative regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] +synonym: "down regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgD isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgD isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "negative regulation of class switching to IgD isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgD isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes +relationship: negatively_regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048301 +name: positive regulation of isotype switching to IgD isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgD isotypes." [GOC:jid] +synonym: "activation of isotype switching to IgD isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgD isotypes" EXACT [] +synonym: "positive regulation of class switching to IgD isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgD isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgD isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgD isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgD isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048299 ! regulation of isotype switching to IgD isotypes +relationship: positively_regulates GO:0048292 ! isotype switching to IgD isotypes + +[Term] +id: GO:0048302 +name: regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] +synonym: "regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "regulation of class switching to IgG isotypes" EXACT [] +synonym: "regulation of isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045191 ! regulation of isotype switching +relationship: regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048303 +name: negative regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] +synonym: "down regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "down-regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "downregulation of isotype switching to IgG isotypes" EXACT [] +synonym: "inhibition of isotype switching to IgG isotypes" NARROW [] +synonym: "negative regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "negative regulation of class switching to IgG isotypes" EXACT [] +synonym: "negative regulation of isotype switch recombination to IgG isotypes" EXACT [] +is_a: GO:0045829 ! negative regulation of isotype switching +is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes +relationship: negatively_regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048304 +name: positive regulation of isotype switching to IgG isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes." [GOC:jid] +synonym: "activation of isotype switching to IgG isotypes" NARROW [] +synonym: "positive regulation of class switch recombination to IgG isotypes" EXACT [] +synonym: "positive regulation of class switching to IgG isotypes" EXACT [] +synonym: "positive regulation of isotype switch recombination to IgG isotypes" EXACT [] +synonym: "stimulation of isotype switching to IgG isotypes" NARROW [] +synonym: "up regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "up-regulation of isotype switching to IgG isotypes" EXACT [] +synonym: "upregulation of isotype switching to IgG isotypes" EXACT [] +is_a: GO:0045830 ! positive regulation of isotype switching +is_a: GO:0048302 ! regulation of isotype switching to IgG isotypes +relationship: positively_regulates GO:0048291 ! isotype switching to IgG isotypes + +[Term] +id: GO:0048306 +name: calcium-dependent protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex in the presence of calcium." [GOC:jid, PMID:10485905] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0048307 +name: ferredoxin-nitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+." [EC:1.7.7.1, GOC:jid] +synonym: "ammonia:ferredoxin oxidoreductase activity" RELATED [EC:1.7.7.1] +xref: EC:1.7.7.1 +xref: MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN +xref: RHEA:18041 +is_a: GO:0016664 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor +is_a: GO:0098809 ! nitrite reductase activity + +[Term] +id: GO:0048308 +name: organelle inheritance +namespace: biological_process +def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] +subset: goslim_pir +subset: goslim_yeast +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0048309 +name: endoplasmic reticulum inheritance +namespace: biological_process +def: "The partitioning of endoplasmic reticulum between daughter cells at cell division." [GOC:jid] +synonym: "ER inheritance" EXACT [] +is_a: GO:0007029 ! endoplasmic reticulum organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0048310 +name: obsolete nucleus inheritance +namespace: biological_process +def: "OBSOLETE. The partitioning of nuclei between daughter cells at cell division." [GOC:jid] +comment: This term was obsoleted because it was not clearly defined. +synonym: "cell nucleus inheritance" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048311 +name: mitochondrion distribution +namespace: biological_process +def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] +synonym: "distribution of mitochondria" EXACT [] +synonym: "mitochondrial distribution" EXACT [] +synonym: "positioning of mitochondria" RELATED [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0051646 ! mitochondrion localization + +[Term] +id: GO:0048312 +name: intracellular distribution of mitochondria +namespace: biological_process +def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] +synonym: "mitochondria positioning within cell" EXACT [] +synonym: "mitochondrion positioning within cell" EXACT [] +is_a: GO:0048311 ! mitochondrion distribution + +[Term] +id: GO:0048313 +name: Golgi inheritance +namespace: biological_process +def: "The partitioning of Golgi apparatus between daughter cells at cell division." [GOC:jid, PMID:12851069] +synonym: "Golgi division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "Golgi partitioning" EXACT [] +is_a: GO:0007030 ! Golgi organization +is_a: GO:0048308 ! organelle inheritance + +[Term] +id: GO:0048314 +name: embryo sac morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants." [GOC:jid, GOC:mtg_plant, http://www.bio.uu.nl] +synonym: "female gametophyte morphogenesis" EXACT [] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0048315 +name: conidium formation +namespace: biological_process +def: "The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, ISBN:0963117211, PMID:2524423, PMID:9529886] +synonym: "conidia biosynthesis" RELATED [] +synonym: "conidia formation" EXACT [] +is_a: GO:0030436 ! asexual sporulation +relationship: part_of GO:0061794 ! conidium development + +[Term] +id: GO:0048316 +name: seed development +namespace: biological_process +def: "The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves." [GOC:jid, PO:0009010] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:0048317 +name: seed morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the seed are generated and organized." [GOC:go_curators] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0048318 +name: axial mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048319 +name: axial mesoderm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the axial mesoderm are generated and organized." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048318 ! axial mesoderm development + +[Term] +id: GO:0048320 +name: axial mesoderm formation +namespace: biological_process +def: "The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048319 ! axial mesoderm morphogenesis + +[Term] +id: GO:0048321 +name: axial mesodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell." [GOC:dgh] +synonym: "axial mesoderm cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048320 ! axial mesoderm formation + +[Term] +id: GO:0048322 +name: axial mesodermal cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become an axial mesoderm cell." [GOC:dgh] +synonym: "axial mesoderm cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048321 ! axial mesodermal cell differentiation + +[Term] +id: GO:0048323 +name: axial mesodermal cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +synonym: "axial mesoderm cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment + +[Term] +id: GO:0048324 +name: regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048325 +name: negative regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "downregulation of axial mesodermal cell fate determination" EXACT [] +synonym: "inhibition of axial mesodermal cell fate determination" NARROW [] +is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +relationship: negatively_regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048326 +name: positive regulation of axial mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of axial mesodermal cell fate determination" NARROW [] +synonym: "stimulation of axial mesodermal cell fate determination" NARROW [] +synonym: "up regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of axial mesodermal cell fate determination" EXACT [] +synonym: "upregulation of axial mesodermal cell fate determination" EXACT [] +is_a: GO:0048324 ! regulation of axial mesodermal cell fate determination +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +relationship: positively_regulates GO:0048323 ! axial mesodermal cell fate determination + +[Term] +id: GO:0048327 +name: axial mesodermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +synonym: "axial mesoderm cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048322 ! axial mesodermal cell fate commitment + +[Term] +id: GO:0048328 +name: regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048329 +name: negative regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "downregulation of axial mesodermal cell fate specification" EXACT [] +synonym: "inhibition of axial mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification +relationship: negatively_regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048330 +name: positive regulation of axial mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axial mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of axial mesodermal cell fate specification" NARROW [] +synonym: "stimulation of axial mesodermal cell fate specification" NARROW [] +synonym: "up regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of axial mesodermal cell fate specification" EXACT [] +synonym: "upregulation of axial mesodermal cell fate specification" EXACT [] +is_a: GO:0048328 ! regulation of axial mesodermal cell fate specification +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +relationship: positively_regulates GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0048331 +name: axial mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "axial mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048319 ! axial mesoderm morphogenesis + +[Term] +id: GO:0048332 +name: mesoderm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesoderm are generated and organized." [GOC:go_curators] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048333 +name: mesodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell." [GOC:dgh] +synonym: "mesoderm cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001707 ! mesoderm formation + +[Term] +id: GO:0048334 +name: regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +is_a: GO:1905770 ! regulation of mesodermal cell differentiation +is_a: GO:1905933 ! regulation of cell fate determination +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048335 +name: negative regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of mesodermal cell fate determination" EXACT [] +synonym: "downregulation of mesodermal cell fate determination" EXACT [] +synonym: "inhibition of mesodermal cell fate determination" NARROW [] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +is_a: GO:1905934 ! negative regulation of cell fate determination +relationship: negatively_regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048336 +name: positive regulation of mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of mesodermal cell fate determination" NARROW [] +synonym: "stimulation of mesodermal cell fate determination" NARROW [] +synonym: "up regulation of mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of mesodermal cell fate determination" EXACT [] +synonym: "upregulation of mesodermal cell fate determination" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +is_a: GO:1905935 ! positive regulation of cell fate determination +relationship: positively_regulates GO:0007500 ! mesodermal cell fate determination + +[Term] +id: GO:0048337 +name: positive regulation of mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of mesodermal cell fate specification" NARROW [] +synonym: "stimulation of mesodermal cell fate specification" NARROW [] +synonym: "up regulation of mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of mesodermal cell fate specification" EXACT [] +synonym: "upregulation of mesodermal cell fate specification" EXACT [] +is_a: GO:0042660 ! positive regulation of cell fate specification +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +is_a: GO:1905772 ! positive regulation of mesodermal cell differentiation +relationship: positively_regulates GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0048338 +name: mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "mesoderm structural organisation" EXACT [] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048332 ! mesoderm morphogenesis + +[Term] +id: GO:0048339 +name: paraxial mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development +is_a: GO:0060485 ! mesenchyme development + +[Term] +id: GO:0048340 +name: paraxial mesoderm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the paraxial mesoderm are generated and organized." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +is_a: GO:0072132 ! mesenchyme morphogenesis +relationship: part_of GO:0048339 ! paraxial mesoderm development + +[Term] +id: GO:0048341 +name: paraxial mesoderm formation +namespace: biological_process +def: "The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis + +[Term] +id: GO:0048342 +name: paraxial mesodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell." [GOC:dgh] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048341 ! paraxial mesoderm formation + +[Term] +id: GO:0048343 +name: paraxial mesodermal cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become a paraxial mesoderm cell." [GOC:dgh] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048342 ! paraxial mesodermal cell differentiation + +[Term] +id: GO:0048344 +name: paraxial mesodermal cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment + +[Term] +id: GO:0048345 +name: regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048346 +name: positive regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of paraxial mesodermal cell fate determination" NARROW [] +synonym: "stimulation of paraxial mesodermal cell fate determination" NARROW [] +synonym: "up regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "upregulation of paraxial mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination +relationship: positively_regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048347 +name: negative regulation of paraxial mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "downregulation of paraxial mesodermal cell fate determination" EXACT [] +synonym: "inhibition of paraxial mesodermal cell fate determination" NARROW [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048345 ! regulation of paraxial mesodermal cell fate determination +relationship: negatively_regulates GO:0048344 ! paraxial mesodermal cell fate determination + +[Term] +id: GO:0048348 +name: paraxial mesodermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048343 ! paraxial mesodermal cell fate commitment + +[Term] +id: GO:0048349 +name: regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048350 +name: positive regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of paraxial mesodermal cell fate specification" NARROW [] +synonym: "stimulation of paraxial mesodermal cell fate specification" NARROW [] +synonym: "up regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "upregulation of paraxial mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification +relationship: positively_regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048351 +name: negative regulation of paraxial mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "downregulation of paraxial mesodermal cell fate specification" EXACT [] +synonym: "inhibition of paraxial mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048349 ! regulation of paraxial mesodermal cell fate specification +relationship: negatively_regulates GO:0048348 ! paraxial mesodermal cell fate specification + +[Term] +id: GO:0048352 +name: paraxial mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "paraxial mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048340 ! paraxial mesoderm morphogenesis + +[Term] +id: GO:0048353 +name: primary endosperm nucleus +namespace: cellular_component +def: "Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac." [ISBN:0471245208] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048354 +name: mucilage biosynthetic process involved in seed coat development +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] +synonym: "mucilage anabolism during seed coat development" EXACT [] +synonym: "mucilage biosynthetic process during seed coat development" RELATED [GOC:dph, GOC:tb] +synonym: "mucilage formation during seed coat development" EXACT [] +synonym: "mucilage synthesis during seed coat development" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +is_a: GO:0048359 ! mucilage metabolic process involved in seed coat development + +[Term] +id: GO:0048355 +name: root cap mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] +synonym: "root cap mucilage anabolism" EXACT [] +synonym: "root cap mucilage biosynthesis" EXACT [] +synonym: "root cap mucilage formation" EXACT [] +synonym: "root cap mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048360 ! root cap mucilage metabolic process + +[Term] +id: GO:0048356 +name: root epithelial mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] +synonym: "root epithelial mucilage anabolism" EXACT [] +synonym: "root epithelial mucilage biosynthesis" EXACT [] +synonym: "root epithelial mucilage formation" EXACT [] +synonym: "root epithelial mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048361 ! root epithelial mucilage metabolic process + +[Term] +id: GO:0048357 +name: pedicel mucilage biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem." [GOC:jid] +synonym: "pedicel mucilage anabolism" EXACT [] +synonym: "pedicel mucilage biosynthesis" EXACT [] +synonym: "pedicel mucilage formation" EXACT [] +synonym: "pedicel mucilage synthesis" EXACT [] +is_a: GO:0010192 ! mucilage biosynthetic process +relationship: part_of GO:0048362 ! pedicel mucilage metabolic process + +[Term] +id: GO:0048358 +name: mucilage pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pectin component of mucilage." [GOC:jid] +synonym: "mucilage pectin anabolism" EXACT [] +synonym: "mucilage pectin biosynthesis" EXACT [] +synonym: "mucilage pectin formation" EXACT [] +synonym: "mucilage pectin synthesis" EXACT [] +is_a: GO:0045489 ! pectin biosynthetic process +is_a: GO:0048363 ! mucilage pectin metabolic process +relationship: part_of GO:0010192 ! mucilage biosynthetic process + +[Term] +id: GO:0048359 +name: mucilage metabolic process involved in seed coat development +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur as part of seed coat development; mucilage is normally synthesized during seed coat development." [GOC:dph, GOC:jid, GOC:tb] +synonym: "mucilage metabolic process during seed coat development" RELATED [GOC:dph, GOC:tb] +synonym: "mucilage metabolism during seed coat development" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0010214 ! seed coat development + +[Term] +id: GO:0048360 +name: root cap mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth." [GOC:jid] +synonym: "root cap mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048361 +name: root epithelial mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth." [GOC:jid] +synonym: "root epithelial mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048362 +name: pedicel mucilage metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucilage that occur in the flower stem." [GOC:jid] +synonym: "pedicel mucilage metabolism" EXACT [] +is_a: GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048363 +name: mucilage pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pectin component of mucilage." [GOC:jid] +synonym: "mucilage pectin metabolism" EXACT [] +is_a: GO:0045488 ! pectin metabolic process +relationship: part_of GO:0010191 ! mucilage metabolic process + +[Term] +id: GO:0048364 +name: root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo." [GOC:jid, PO:0009005] +is_a: GO:0099402 ! plant organ development +relationship: part_of GO:0022622 ! root system development + +[Term] +id: GO:0048366 +name: leaf development +namespace: biological_process +def: "The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048827 ! phyllome development + +[Term] +id: GO:0048367 +name: shoot system development +namespace: biological_process +alt_id: GO:0022621 +def: "The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure." [GOC:go_curators] +synonym: "shoot development" EXACT [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0048368 +name: lateral mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure." [GOC:go_curators] +synonym: "lateral plate mesoderm development" EXACT [] +is_a: GO:0007498 ! mesoderm development +is_a: GO:0060485 ! mesenchyme development + +[Term] +id: GO:0048369 +name: lateral mesoderm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the lateral mesoderm are generated and organized." [GOC:go_curators] +synonym: "lateral plate mesoderm morphogenesis" EXACT [] +is_a: GO:0048332 ! mesoderm morphogenesis +is_a: GO:0072132 ! mesenchyme morphogenesis +relationship: part_of GO:0048368 ! lateral mesoderm development + +[Term] +id: GO:0048370 +name: lateral mesoderm formation +namespace: biological_process +def: "The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:jid] +synonym: "lateral plate mesoderm biosynthesis" EXACT [] +synonym: "lateral plate mesoderm formation" EXACT [] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis + +[Term] +id: GO:0048371 +name: lateral mesodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell." [GOC:jid] +synonym: "lateral mesoderm cell differentiation" EXACT [] +synonym: "lateral plate mesoderm cell differentiation" EXACT [] +synonym: "lateral plate mesodermal cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048370 ! lateral mesoderm formation + +[Term] +id: GO:0048372 +name: lateral mesodermal cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become a lateral mesoderm cell." [GOC:jid] +synonym: "lateral mesoderm cell fate commitment" EXACT [] +synonym: "lateral plate mesoderm cell fate commitment" EXACT [] +synonym: "lateral plate mesodermal cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048371 ! lateral mesodermal cell differentiation + +[Term] +id: GO:0048373 +name: lateral mesodermal cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:jid] +synonym: "lateral mesoderm cell fate determination" EXACT [] +synonym: "lateral plate mesoderm cell fate determination" EXACT [] +synonym: "lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment + +[Term] +id: GO:0048374 +name: regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] +synonym: "regulation of lateral mesoderm cell fate determination" EXACT [] +synonym: "regulation of lateral plate mesoderm cell fate determination" EXACT [] +synonym: "regulation of lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048375 +name: negative regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] +synonym: "down regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "downregulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "inhibition of lateral mesodermal cell fate determination" NARROW [] +synonym: "negative regulation of lateral plate mesodermal cell fate determination" EXACT [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination +relationship: negatively_regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048376 +name: positive regulation of lateral mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate determination." [GOC:jid] +synonym: "activation of lateral mesodermal cell fate determination" NARROW [] +synonym: "positive regulation of lateral plate mesodermal cell fate determination" EXACT [] +synonym: "stimulation of lateral mesodermal cell fate determination" NARROW [] +synonym: "up regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of lateral mesodermal cell fate determination" EXACT [] +synonym: "upregulation of lateral mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048374 ! regulation of lateral mesodermal cell fate determination +relationship: positively_regulates GO:0048373 ! lateral mesodermal cell fate determination + +[Term] +id: GO:0048377 +name: lateral mesodermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:jid] +synonym: "lateral mesoderm cell fate specification" EXACT [] +synonym: "lateral plate mesoderm cell fate specification" EXACT [] +synonym: "lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048372 ! lateral mesodermal cell fate commitment + +[Term] +id: GO:0048378 +name: regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] +synonym: "regulation of lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048379 +name: positive regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] +synonym: "activation of lateral mesodermal cell fate specification" NARROW [] +synonym: "positive regulation of lateral plate mesodermal cell fate specification" EXACT [] +synonym: "stimulation of lateral mesodermal cell fate specification" NARROW [] +synonym: "up regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "upregulation of lateral mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification +relationship: positively_regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048380 +name: negative regulation of lateral mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate specification." [GOC:jid] +synonym: "down regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "downregulation of lateral mesodermal cell fate specification" EXACT [] +synonym: "inhibition of lateral mesodermal cell fate specification" NARROW [] +synonym: "negative regulation of lateral plate mesodermal cell fate specification" EXACT [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048378 ! regulation of lateral mesodermal cell fate specification +relationship: negatively_regulates GO:0048377 ! lateral mesodermal cell fate specification + +[Term] +id: GO:0048381 +name: lateral mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "lateral mesoderm structural organisation" EXACT [] +synonym: "lateral plate mesoderm structural organization" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048369 ! lateral mesoderm morphogenesis + +[Term] +id: GO:0048382 +name: mesendoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues." [GOC:jid] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007492 ! endoderm development +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048383 +name: mesectoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues." [GOC:jid] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0007398 ! ectoderm development +relationship: part_of GO:0007498 ! mesoderm development + +[Term] +id: GO:0048384 +name: retinoic acid receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands." [GOC:dgh] +synonym: "RAR signaling pathway" EXACT [] +synonym: "retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0030522 ! intracellular receptor signaling pathway + +[Term] +id: GO:0048385 +name: regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "regulation of RAR signaling pathway" EXACT [] +synonym: "regulation of retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048386 +name: positive regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "activation of retinoic acid receptor signaling pathway" NARROW [] +synonym: "positive regulation of RAR signaling pathway" EXACT [] +synonym: "positive regulation of retinoic acid receptor signalling pathway" EXACT [] +synonym: "stimulation of retinoic acid receptor signaling pathway" NARROW [] +synonym: "up regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "up-regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "upregulation of retinoic acid receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway +relationship: positively_regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048387 +name: negative regulation of retinoic acid receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of retinoic acid receptor signaling pathway activity." [GOC:dgh] +synonym: "down regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "down-regulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "downregulation of retinoic acid receptor signaling pathway" EXACT [] +synonym: "inhibition of retinoic acid receptor signaling pathway" NARROW [] +synonym: "negative regulation of RAR signaling pathway" EXACT [] +synonym: "negative regulation of RAR signalling pathway" EXACT [] +synonym: "negative regulation of retinoic acid receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0048385 ! regulation of retinoic acid receptor signaling pathway +relationship: negatively_regulates GO:0048384 ! retinoic acid receptor signaling pathway + +[Term] +id: GO:0048388 +name: endosomal lumen acidification +namespace: biological_process +def: "Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] +is_a: GO:0051452 ! intracellular pH reduction +relationship: part_of GO:0007032 ! endosome organization + +[Term] +id: GO:0048389 +name: intermediate mesoderm development +namespace: biological_process +def: "The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads." [GOC:dgh] +is_a: GO:0007498 ! mesoderm development + +[Term] +id: GO:0048390 +name: intermediate mesoderm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the intermediate mesoderm are generated and organized." [GOC:go_curators] +is_a: GO:0048332 ! mesoderm morphogenesis +relationship: part_of GO:0048389 ! intermediate mesoderm development + +[Term] +id: GO:0048391 +name: intermediate mesoderm formation +namespace: biological_process +def: "The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:dgh] +is_a: GO:0001707 ! mesoderm formation +relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis + +[Term] +id: GO:0048392 +name: intermediate mesodermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell." [GOC:dgh] +synonym: "intermediate mesoderm cell differentiation" EXACT [] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0048391 ! intermediate mesoderm formation + +[Term] +id: GO:0048393 +name: intermediate mesodermal cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell." [GOC:dgh] +synonym: "intermediate mesoderm cell fate commitment" EXACT [] +is_a: GO:0001710 ! mesodermal cell fate commitment +relationship: part_of GO:0048392 ! intermediate mesodermal cell differentiation + +[Term] +id: GO:0048394 +name: intermediate mesodermal cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dgh] +synonym: "intermediate mesoderm cell fate determination" EXACT [] +is_a: GO:0007500 ! mesodermal cell fate determination +relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment + +[Term] +id: GO:0048395 +name: regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +is_a: GO:0048334 ! regulation of mesodermal cell fate determination +relationship: regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048396 +name: negative regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +synonym: "down regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "down-regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "downregulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "inhibition of intermediate mesodermal cell fate determination" NARROW [] +is_a: GO:0048335 ! negative regulation of mesodermal cell fate determination +is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination +relationship: negatively_regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048397 +name: positive regulation of intermediate mesodermal cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate determination." [GOC:dgh] +synonym: "activation of intermediate mesodermal cell fate determination" NARROW [] +synonym: "stimulation of intermediate mesodermal cell fate determination" NARROW [] +synonym: "up regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "up-regulation of intermediate mesodermal cell fate determination" EXACT [] +synonym: "upregulation of intermediate mesodermal cell fate determination" EXACT [] +is_a: GO:0048336 ! positive regulation of mesodermal cell fate determination +is_a: GO:0048395 ! regulation of intermediate mesodermal cell fate determination +relationship: positively_regulates GO:0048394 ! intermediate mesodermal cell fate determination + +[Term] +id: GO:0048398 +name: intermediate mesodermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dgh] +synonym: "intermediate mesoderm cell fate specification" EXACT [] +is_a: GO:0007501 ! mesodermal cell fate specification +relationship: part_of GO:0048393 ! intermediate mesodermal cell fate commitment + +[Term] +id: GO:0048399 +name: regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +is_a: GO:0042661 ! regulation of mesodermal cell fate specification +relationship: regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048400 +name: positive regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +synonym: "activation of intermediate mesodermal cell fate specification" NARROW [] +synonym: "stimulation of intermediate mesodermal cell fate specification" NARROW [] +synonym: "up regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "up-regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "upregulation of intermediate mesodermal cell fate specification" EXACT [] +is_a: GO:0048337 ! positive regulation of mesodermal cell fate specification +is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification +relationship: positively_regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048401 +name: negative regulation of intermediate mesodermal cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate mesoderm cell fate specification." [GOC:dgh] +synonym: "down regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "down-regulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "downregulation of intermediate mesodermal cell fate specification" EXACT [] +synonym: "inhibition of intermediate mesodermal cell fate specification" NARROW [] +is_a: GO:0042662 ! negative regulation of mesodermal cell fate specification +is_a: GO:0048399 ! regulation of intermediate mesodermal cell fate specification +relationship: negatively_regulates GO:0048398 ! intermediate mesodermal cell fate specification + +[Term] +id: GO:0048402 +name: intermediate mesoderm structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure." [GOC:dgh] +synonym: "intermediate mesoderm structural organisation" EXACT [] +is_a: GO:0048338 ! mesoderm structural organization +relationship: part_of GO:0048390 ! intermediate mesoderm morphogenesis + +[Term] +id: GO:0048403 +name: brain-derived neurotrophic factor binding +namespace: molecular_function +def: "Binding to brain-derived neurotrophic factor." [GOC:dgh] +synonym: "BDNF binding" EXACT [] +synonym: "neurotrophin TRKB receptor activity" RELATED [] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048406 +name: nerve growth factor binding +namespace: molecular_function +def: "Binding to nerve growth factor (NGF)." [GOC:dgh] +synonym: "beta-nerve growth factor binding" EXACT [PR:000011194] +synonym: "neurotrophin TRKA receptor activity" RELATED [] +synonym: "NGF binding" EXACT [PR:000011194] +is_a: GO:0043121 ! neurotrophin binding + +[Term] +id: GO:0048407 +name: platelet-derived growth factor binding +namespace: molecular_function +def: "Binding to platelet-derived growth factor." [GOC:dgh] +synonym: "PDGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding + +[Term] +id: GO:0048408 +name: epidermal growth factor binding +namespace: molecular_function +def: "Binding to epidermal growth factor." [GOC:dgh] +synonym: "EGF binding" EXACT [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0048437 +name: floral organ development +namespace: biological_process +alt_id: GO:0048433 +def: "The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure." [GOC:go_curators, GOC:PO_curators, PO:0025395] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0099402 ! plant organ development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048438 +name: floral whorl development +namespace: biological_process +alt_id: GO:0048413 +def: "The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant." [GOC:dph, GOC:go_curators, GOC:PO_curators, GOC:tb, PO:0025023] +comment: Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms. +synonym: "collective phyllome structure development" BROAD [GOC:PO_curators, PO:0025023] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048439 +name: flower morphogenesis +namespace: biological_process +alt_id: GO:0048411 +def: "The process in which the anatomical structures of the flower are generated and organized." [GOC:go_curators] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010016 ! shoot system morphogenesis +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048440 +name: carpel development +namespace: biological_process +alt_id: GO:0048429 +def: "The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +is_a: GO:0048827 ! phyllome development +relationship: part_of GO:0048467 ! gynoecium development + +[Term] +id: GO:0048441 +name: petal development +namespace: biological_process +alt_id: GO:0048417 +def: "The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +is_a: GO:0048827 ! phyllome development +relationship: part_of GO:0048465 ! corolla development + +[Term] +id: GO:0048442 +name: sepal development +namespace: biological_process +alt_id: GO:0048421 +def: "The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +is_a: GO:0048827 ! phyllome development +relationship: part_of GO:0048464 ! flower calyx development + +[Term] +id: GO:0048443 +name: stamen development +namespace: biological_process +alt_id: GO:0048425 +def: "The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048437 ! floral organ development +is_a: GO:0048827 ! phyllome development +relationship: part_of GO:0048466 ! androecium development + +[Term] +id: GO:0048444 +name: floral organ morphogenesis +namespace: biological_process +alt_id: GO:0048434 +def: "The process in which the anatomical structures of the floral organ are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025395] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090697 ! post-embryonic plant organ morphogenesis +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0048445 +name: carpel morphogenesis +namespace: biological_process +alt_id: GO:0048430 +def: "The process in which the anatomical structures of the carpel are generated and organized." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048446 +name: petal morphogenesis +namespace: biological_process +alt_id: GO:0048418 +def: "The process in which the anatomical structures of the petal are generated and organized." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048441 ! petal development + +[Term] +id: GO:0048447 +name: sepal morphogenesis +namespace: biological_process +alt_id: GO:0048422 +def: "The process in which the anatomical structures of the sepal are generated and organized." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048442 ! sepal development + +[Term] +id: GO:0048448 +name: stamen morphogenesis +namespace: biological_process +alt_id: GO:0048426 +def: "The process in which the anatomical structures of the stamen are generated and organized." [GOC:go_curators] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048443 ! stamen development + +[Term] +id: GO:0048449 +name: floral organ formation +namespace: biological_process +alt_id: GO:0048436 +def: "The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025395] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:1905393 ! plant organ formation +relationship: part_of GO:0048444 ! floral organ morphogenesis + +[Term] +id: GO:0048450 +name: floral organ structural organization +namespace: biological_process +alt_id: GO:0048435 +def: "The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025395] +synonym: "floral organ structural organisation" EXACT [] +is_a: GO:0048444 ! floral organ morphogenesis +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048461 ! flower structural organization + +[Term] +id: GO:0048451 +name: petal formation +namespace: biological_process +alt_id: GO:0048419 +def: "The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048452 +name: petal structural organization +namespace: biological_process +alt_id: GO:0048420 +def: "The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "petal structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048453 +name: sepal formation +namespace: biological_process +alt_id: GO:0048423 +def: "The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048447 ! sepal morphogenesis + +[Term] +id: GO:0048454 +name: sepal structural organization +namespace: biological_process +alt_id: GO:0048424 +def: "The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "sepal structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048447 ! sepal morphogenesis + +[Term] +id: GO:0048455 +name: stamen formation +namespace: biological_process +alt_id: GO:0048427 +def: "The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048448 ! stamen morphogenesis + +[Term] +id: GO:0048456 +name: stamen structural organization +namespace: biological_process +alt_id: GO:0048428 +def: "The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "stamen structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048448 ! stamen morphogenesis + +[Term] +id: GO:0048457 +name: floral whorl morphogenesis +namespace: biological_process +alt_id: GO:0048414 +def: "The process in which the anatomical structures of the floral whorl are generated and organized." [GOC:go_curators, GOC:PO_curators, PO:0025023] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0048438 ! floral whorl development +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048458 +name: floral whorl formation +namespace: biological_process +alt_id: GO:0048415 +def: "The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid, GOC:PO_curators, PO:0025023] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048457 ! floral whorl morphogenesis + +[Term] +id: GO:0048459 +name: floral whorl structural organization +namespace: biological_process +alt_id: GO:0048416 +def: "The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid, GOC:PO_curators, PO:0025023] +synonym: "floral whorl structural organisation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048457 ! floral whorl morphogenesis +relationship: part_of GO:0048461 ! flower structural organization + +[Term] +id: GO:0048460 +name: flower formation +namespace: biological_process +alt_id: GO:0048410 +def: "The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048461 +name: flower structural organization +namespace: biological_process +alt_id: GO:0048412 +def: "The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "flower structural organisation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048462 +name: carpel formation +namespace: biological_process +alt_id: GO:0048431 +def: "The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts." [GOC:jid] +is_a: GO:0048449 ! floral organ formation +relationship: part_of GO:0048445 ! carpel morphogenesis + +[Term] +id: GO:0048463 +name: carpel structural organization +namespace: biological_process +alt_id: GO:0048432 +def: "The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure." [GOC:jid] +synonym: "carpel structural organisation" EXACT [] +is_a: GO:0048450 ! floral organ structural organization +relationship: part_of GO:0048445 ! carpel morphogenesis + +[Term] +id: GO:0048464 +name: flower calyx development +namespace: biological_process +def: "The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048465 +name: corolla development +namespace: biological_process +def: "The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048466 +name: androecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure." [GOC:go_curators] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048467 +name: gynoecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower." [GOC:go_curators, PO:0008062] +synonym: "pistil development" EXACT [] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0048468 +name: cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] +subset: goslim_candida +synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +is_a: GO:0048869 ! cellular developmental process +relationship: part_of GO:0030154 ! cell differentiation + +[Term] +id: GO:0048469 +name: cell maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state." [GOC:go_curators] +subset: goslim_pir +synonym: "functional differentiation" RELATED [GOC:dph] +is_a: GO:0048869 ! cellular developmental process +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0048471 +name: perinuclear region of cytoplasm +namespace: cellular_component +def: "Cytoplasm situated near, or occurring around, the nucleus." [GOC:jid] +comment: Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0048472 +name: threonine-phosphate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2)." [EC:4.1.1.81, RHEA:11492] +synonym: "CobD" RELATED [EC:4.1.1.81] +synonym: "L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]" RELATED [EC:4.1.1.81] +synonym: "L-threonine O-3-phosphate carboxy-lyase activity" RELATED [EC:4.1.1.81] +synonym: "L-threonine-O-3-phosphate decarboxylase activity" EXACT [] +xref: EC:4.1.1.81 +xref: KEGG_REACTION:R06530 +xref: MetaCyc:4.1.1.81-RXN +xref: RHEA:11492 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0048473 +name: D-methionine transport +namespace: biological_process +def: "The directed movement of D-methionine into, out of, within, or between cells." [GOC:mlg, PMID:12169620] +is_a: GO:0015821 ! methionine transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0048475 +name: coated membrane +namespace: cellular_component +def: "A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes." [GOC:jid] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0048476 +name: Holliday junction resolvase complex +namespace: cellular_component +def: "An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated." [PMID:11207366, PMID:12374758] +subset: goslim_pir +synonym: "Mus81-Eme1 complex" NARROW [] +synonym: "Mus81-Eme1 holliday resolvase complex" NARROW [] +synonym: "Mus81-Eme2 complex" NARROW [] +synonym: "Mus81-Eme2 holliday resolvase complex" NARROW [] +synonym: "resolvasome" EXACT [PMID:11207366] +is_a: GO:1905347 ! endodeoxyribonuclease complex + +[Term] +id: GO:0048477 +name: oogenesis +namespace: biological_process +alt_id: GO:0009993 +alt_id: GO:0048157 +def: "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." [GOC:kmv, GOC:mtg_sensu, GOC:pr] +synonym: "ovum development" EXACT systematic_synonym [] +xref: Wikipedia:Oogenesis +is_a: GO:0007281 ! germ cell development +is_a: GO:0007292 ! female gamete generation + +[Term] +id: GO:0048478 +name: replication fork protection +namespace: biological_process +def: "Any process that prevents the collapse of stalled replication forks." [GOC:vw, PMID:14560029] +synonym: "replication fork maintenance" BROAD [] +synonym: "replication fork stabilization" BROAD [] +is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication + +[Term] +id: GO:0048479 +name: style development +namespace: biological_process +def: "The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma." [GOC:jid, PO:0009074] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048480 +name: stigma development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky." [GOC:jid, PO:0009073] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048440 ! carpel development + +[Term] +id: GO:0048481 +name: plant ovule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0099402 ! plant organ development +relationship: part_of GO:0035670 ! plant-type ovary development + +[Term] +id: GO:0048482 +name: plant ovule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090698 ! post-embryonic plant morphogenesis +is_a: GO:1905392 ! plant organ morphogenesis +relationship: part_of GO:0048445 ! carpel morphogenesis +relationship: part_of GO:0048481 ! plant ovule development + +[Term] +id: GO:0048483 +name: autonomic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands." [FMA:9905, GOC:jid, GOC:sr] +is_a: GO:0048731 ! system development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0048484 +name: enteric nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation." [FMA:66070, GOC:jid, GOC:sr] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048485 +name: sympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter." [FMA:9906, GOC:jid, GOC:sr] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048486 +name: parasympathetic nervous system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [FMA:9907, GOC:jid, GOC:sr] +is_a: GO:0048731 ! system development +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0048487 +name: beta-tubulin binding +namespace: molecular_function +def: "Binding to the microtubule constituent protein beta-tubulin." [GOC:krc] +synonym: "beta tubulin binding" EXACT [] +is_a: GO:0015631 ! tubulin binding + +[Term] +id: GO:0048488 +name: synaptic vesicle endocytosis +namespace: biological_process +alt_id: GO:0008099 +def: "A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111] +subset: goslim_synapse +synonym: "synaptic vesicle retrieval" RELATED [] +is_a: GO:0140238 ! presynaptic endocytosis +relationship: part_of GO:0036465 ! synaptic vesicle recycling + +[Term] +id: GO:0048489 +name: synaptic vesicle transport +namespace: biological_process +alt_id: GO:0016181 +def: "The directed movement of synaptic vesicles." [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:pr] +subset: goslim_synapse +synonym: "synaptic vesicle fission" RELATED [] +synonym: "synaptic vesicle fusion" RELATED [] +synonym: "synaptic vesicle trafficking" RELATED [PMID:15217342] +is_a: GO:0006810 ! transport +is_a: GO:0051650 ! establishment of vesicle localization +is_a: GO:0097479 ! synaptic vesicle localization + +[Term] +id: GO:0048490 +name: anterograde synaptic vesicle transport +namespace: biological_process +def: "The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse." [GOC:jid, GOC:lmg] +subset: goslim_synapse +synonym: "anterograde axonal transport of synaptic vesicle" EXACT [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0099517 ! synaptic vesicle transport along microtubule + +[Term] +id: GO:0048491 +name: retrograde synaptic vesicle transport +namespace: biological_process +def: "The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body." [GOC:jid, GOC:lmg, PMID:24762653] +subset: goslim_synapse +synonym: "retrograde axonal transport of synaptic vesicle" EXACT [] +is_a: GO:0008090 ! retrograde axonal transport +is_a: GO:0099517 ! synaptic vesicle transport along microtubule + +[Term] +id: GO:0048492 +name: ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg] +subset: goslim_pir +synonym: "RubisCO complex" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0048493 +name: plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] +synonym: "plasma membrane ribulose bisphosphate carboxylase complex" EXACT [] +synonym: "ribulose bisphosphate carboxylase complex" BROAD [] +synonym: "RubisCO complex" BROAD [] +is_a: GO:0048494 ! chromatophore ribulose bisphosphate carboxylase complex +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0030075 ! bacterial thylakoid + +[Term] +id: GO:0048494 +name: chromatophore ribulose bisphosphate carboxylase complex +namespace: cellular_component +def: "A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate." [GOC:mlg, GOC:mtg_sensu] +synonym: "RubisCO complex" BROAD [] +is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex +relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore + +[Term] +id: GO:0048495 +name: Roundabout binding +namespace: molecular_function +def: "Binding to Roundabout (ROBO) receptor, a transmembrane receptor." [GOC:ecd, PMID:10102268, PMID:10197527] +synonym: "Roundabout receptor binding" RELATED [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0048496 +name: maintenance of animal organ identity +namespace: biological_process +def: "The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0048497 +name: maintenance of floral organ identity +namespace: biological_process +def: "The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:PO_curators, GOC:tair_curators, PMID:9090883, PO:0025395] +is_a: GO:0022414 ! reproductive process +is_a: GO:0090700 ! maintenance of plant organ identity +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0048498 +name: establishment of petal orientation +namespace: biological_process +def: "The process that determines the orientation of petals with reference to the central axis." [GOC:tb, PMID:10572040] +is_a: GO:0048559 ! establishment of floral organ orientation +relationship: part_of GO:0048446 ! petal morphogenesis + +[Term] +id: GO:0048499 +name: synaptic vesicle membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle." [GOC:dph, GOC:jl, GOC:mah, PMID:10620806] +synonym: "SLMV biogenesis" NARROW [] +synonym: "synaptic vesicle membrane organisation" EXACT [] +synonym: "synaptic vesicle membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0010256 ! endomembrane system organization + +[Term] +id: GO:0048500 +name: signal recognition particle +namespace: cellular_component +def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] +subset: goslim_metagenomics +subset: goslim_pir +xref: Wikipedia:Signal_recognition_particle +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0048501 +name: signal recognition particle, plasma membrane targeting +namespace: cellular_component +def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane." [GOC:mlg, GOC:mtg_sensu] +is_a: GO:0048500 ! signal recognition particle + +[Term] +id: GO:0048502 +name: ABC-type thiamine transporter activity +namespace: molecular_function +alt_id: GO:0015619 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in)." [PMID:12175925, PMID:9535878, RHEA:29811] +synonym: "ATP-dependent thiamine transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled thiamine transmembrane transporter activity" RELATED [] +synonym: "thiamin pyrophosphate ABC transporter" EXACT [] +synonym: "thiamin pyrophosphate porter activity" BROAD [] +synonym: "thiamin pyrophosphate transporting ATPase activity" RELATED [] +synonym: "thiamin-transporting ATPase activity" RELATED [] +synonym: "thiamine ABC transporter" EXACT [] +synonym: "thiamine pyrophosphate-transporting ATPase activity" RELATED [] +synonym: "thiamine-transporting ATPase activity" RELATED [] +synonym: "TPP transporting ATPase activity" RELATED [] +xref: EC:7.6.2.15 +xref: RHEA:29811 +xref: TC:3.A.1.19.1 +is_a: GO:0015234 ! thiamine transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140394 ! ABC-type azole transporter activity + +[Term] +id: GO:0048503 +name: obsolete GPI anchor binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes." [GOC:vw] +comment: This term was made obsolete because it has been widely, and incorrectly, used to annotate proteins that have GPI anchors covalently attached. A new term has been created that can be used to annotate gene products that interact non-covalently with GPI anchors. +synonym: "glycosylphosphatidylinositol binding" EXACT [] +synonym: "GPI anchor binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048504 +name: regulation of timing of animal organ formation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] +synonym: "timing of organ biosynthesis" RELATED [] +synonym: "timing of organ formation" RELATED [] +is_a: GO:0003156 ! regulation of animal organ formation +is_a: GO:0040034 ! regulation of development, heterochronic + +[Term] +id: GO:0048505 +name: regulation of timing of cell differentiation +namespace: biological_process +def: "The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development." [GOC:bf, GOC:dph, GOC:jid, GOC:tb] +synonym: "timing of cell differentiation" RELATED [] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:0045595 ! regulation of cell differentiation + +[Term] +id: GO:0048506 +name: regulation of timing of meristematic phase transition +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point." [GOC:dph, GOC:jid, GOC:tb] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:0048509 ! regulation of meristem development + +[Term] +id: GO:0048507 +name: meristem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0048508 +name: embryonic meristem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048507 ! meristem development +relationship: part_of GO:0009793 ! embryo development ending in seed dormancy + +[Term] +id: GO:0048509 +name: regulation of meristem development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048507 ! meristem development + +[Term] +id: GO:0048510 +name: regulation of timing of transition from vegetative to reproductive phase +namespace: biological_process +def: "The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs." [GOC:jid, PMID:8974397] +is_a: GO:0048506 ! regulation of timing of meristematic phase transition + +[Term] +id: GO:0048511 +name: rhythmic process +namespace: biological_process +def: "Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism." [GOC:jid] +subset: goslim_pir +synonym: "rhythm" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0048512 +name: circadian behavior +namespace: biological_process +def: "The specific behavior of an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators, GOC:pr] +synonym: "circadian rhythm behavior" EXACT [] +is_a: GO:0007622 ! rhythmic behavior +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0048513 +name: animal organ development +namespace: biological_process +def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] +synonym: "development of an organ" EXACT [] +synonym: "organogenesis" EXACT [] +xref: Wikipedia:Organogenesis +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048731 ! system development + +[Term] +id: GO:0048514 +name: blood vessel morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:jid] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0048515 +name: spermatid differentiation +namespace: biological_process +def: "The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:jid] +synonym: "spermatid cell differentiation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0048516 +name: obsolete trichome initiation (sensu Magnoliophyta) +namespace: biological_process +def: "OBSOLETE. Processes causing the differentiation of an epidermal cell into a trichome cell; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "trichome initiation (sensu Magnoliophyta)" EXACT [] +is_obsolete: true +consider: GO:0048629 + +[Term] +id: GO:0048517 +name: obsolete positive regulation of trichome initiation (sensu Magnoliophyta) +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of trichome initiation; as in, but not restricted to, the flowering plants (Magnoliophyta, ncbi_taxonomy_id:3398)." [GOC:lr] +comment: This term was made obsolete because more appropriate terms were created. +synonym: "positive regulation of trichome initiation (sensu Magnoliophyta)" EXACT [] +is_obsolete: true +consider: GO:0048629 + +[Term] +id: GO:0048518 +name: positive regulation of biological process +namespace: biological_process +alt_id: GO:0043119 +def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] +subset: gocheck_do_not_annotate +synonym: "activation of biological process" NARROW [] +synonym: "positive regulation of physiological process" EXACT [] +synonym: "stimulation of biological process" NARROW [] +synonym: "up regulation of biological process" EXACT [] +synonym: "up-regulation of biological process" EXACT [] +synonym: "upregulation of biological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: positively_regulates GO:0008150 ! biological_process + +[Term] +id: GO:0048519 +name: negative regulation of biological process +namespace: biological_process +alt_id: GO:0043118 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] +subset: gocheck_do_not_annotate +synonym: "down regulation of biological process" EXACT [] +synonym: "down-regulation of biological process" EXACT [] +synonym: "downregulation of biological process" EXACT [] +synonym: "inhibition of biological process" NARROW [] +synonym: "negative regulation of physiological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: negatively_regulates GO:0008150 ! biological_process + +[Term] +id: GO:0048520 +name: positive regulation of behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] +synonym: "activation of behavior" NARROW [] +synonym: "stimulation of behavior" NARROW [] +synonym: "up regulation of behavior" EXACT [] +synonym: "up-regulation of behavior" EXACT [] +synonym: "upregulation of behavior" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050795 ! regulation of behavior +relationship: positively_regulates GO:0007610 ! behavior + +[Term] +id: GO:0048521 +name: negative regulation of behavior +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:jid, GOC:pr] +synonym: "down regulation of behavior" EXACT [] +synonym: "down-regulation of behavior" EXACT [] +synonym: "downregulation of behavior" EXACT [] +synonym: "inhibition of behavior" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050795 ! regulation of behavior +relationship: negatively_regulates GO:0007610 ! behavior + +[Term] +id: GO:0048522 +name: positive regulation of cellular process +namespace: biological_process +alt_id: GO:0051242 +def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] +subset: gocheck_do_not_annotate +synonym: "activation of cellular process" NARROW [] +synonym: "positive regulation of cellular physiological process" EXACT [] +synonym: "stimulation of cellular process" NARROW [] +synonym: "up regulation of cellular process" EXACT [] +synonym: "up-regulation of cellular process" EXACT [] +synonym: "upregulation of cellular process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050794 ! regulation of cellular process +relationship: positively_regulates GO:0009987 ! cellular process + +[Term] +id: GO:0048523 +name: negative regulation of cellular process +namespace: biological_process +alt_id: GO:0051243 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] +subset: gocheck_do_not_annotate +synonym: "down regulation of cellular process" EXACT [] +synonym: "down-regulation of cellular process" EXACT [] +synonym: "downregulation of cellular process" EXACT [] +synonym: "inhibition of cellular process" NARROW [] +synonym: "negative regulation of cellular physiological process" EXACT [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050794 ! regulation of cellular process +relationship: negatively_regulates GO:0009987 ! cellular process + +[Term] +id: GO:0048524 +name: positive regulation of viral process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl] +synonym: "activation of viral life cycle" NARROW [] +synonym: "positive regulation of viral life cycle" NARROW [GOC:tb] +synonym: "positive regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] +synonym: "stimulation of viral life cycle" NARROW [] +synonym: "up regulation of viral life cycle" NARROW [] +synonym: "up-regulation of viral life cycle" NARROW [] +synonym: "upregulation of viral life cycle" NARROW [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050792 ! regulation of viral process +relationship: positively_regulates GO:0016032 ! viral process + +[Term] +id: GO:0048525 +name: negative regulation of viral process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant." [GOC:bf, GOC:jl] +synonym: "down regulation of viral life cycle" NARROW [] +synonym: "down-regulation of viral life cycle" NARROW [] +synonym: "downregulation of viral life cycle" NARROW [] +synonym: "inhibition of viral life cycle" NARROW [] +synonym: "negative regulation of viral life cycle" NARROW [GOC:tb] +synonym: "negative regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050792 ! regulation of viral process +relationship: negatively_regulates GO:0016032 ! viral process + +[Term] +id: GO:0048526 +name: imaginal disc-derived wing expansion +namespace: biological_process +def: "The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing." [GOC:mtg_sensu, GOC:rc] +synonym: "wing expansion" EXACT [] +synonym: "wing inflation" EXACT [] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0048527 +name: lateral root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tb] +is_a: GO:0048528 ! post-embryonic root development + +[Term] +id: GO:0048528 +name: post-embryonic root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0048364 ! root development +is_a: GO:0090696 ! post-embryonic plant organ development + +[Term] +id: GO:0048529 +name: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O." [EC:1.14.13.81, RHEA:33235] +synonym: "magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.13.81] +synonym: "Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity" RELATED [EC:1.14.13.81] +synonym: "Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity" RELATED [EC:1.14.13.81] +xref: EC:1.14.13.81 +xref: RHEA:33235 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0048530 +name: fruit morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant." [GOC:sm] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:0048531 +name: beta-1,3-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage." [PMID:11551958] +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:0048532 +name: anatomical structure arrangement +namespace: biological_process +def: "The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:go_curators] +synonym: "anatomical structure organization" BROAD [] +synonym: "anatomical structure structural organization" EXACT [] +synonym: "organization of an anatomical structure" EXACT [] +synonym: "structural organization" EXACT [] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048533 +name: sporocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores." [GOC:tair_curators] +synonym: "sporocyte development" NARROW [] +synonym: "sporocyte morphogenesis" RELATED [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048534 +name: hematopoietic or lymphoid organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation." [GOC:add, GOC:rl, ISBN:0781735149] +synonym: "haematopoietic or lymphoid organ development" EXACT [] +synonym: "haemopoietic or lymphoid organ development" EXACT [] +synonym: "hemopoietic or lymphoid organ development" EXACT [] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0002520 ! immune system development + +[Term] +id: GO:0048535 +name: lymph node development +namespace: biological_process +def: "The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:068340007X, ISBN:0781735149] +synonym: "lymph gland development" BROAD [] +is_a: GO:0048534 ! hematopoietic or lymphoid organ development + +[Term] +id: GO:0048536 +name: spleen development +namespace: biological_process +def: "The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions." [GOC:add, ISBN:0781735149] +is_a: GO:0048534 ! hematopoietic or lymphoid organ development + +[Term] +id: GO:0048537 +name: mucosa-associated lymphoid tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] +synonym: "BALT development" NARROW [] +synonym: "bronchial-associated lymphoid tissue development" NARROW [] +synonym: "GALT development" NARROW [] +synonym: "gut-associated lymphoid tissue development" NARROW [] +synonym: "mucosal-associated lymphoid tissue development" EXACT [] +synonym: "NALT development" NARROW [] +synonym: "nasopharyngeal-associated lymphoid tissue development" NARROW [] +is_a: GO:0009888 ! tissue development +is_a: GO:0048534 ! hematopoietic or lymphoid organ development + +[Term] +id: GO:0048538 +name: thymus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components." [GOC:add, ISBN:0781735149] +comment: Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. +is_a: GO:0048534 ! hematopoietic or lymphoid organ development +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048539 +name: bone marrow development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure." [GOC:add, ISBN:0781735149] +is_a: GO:0009888 ! tissue development +is_a: GO:0048534 ! hematopoietic or lymphoid organ development +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0048540 +name: bursa of Fabricius development +namespace: biological_process +def: "The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation." [GOC:add, ISBN:0781735149] +is_a: GO:0048534 ! hematopoietic or lymphoid organ development + +[Term] +id: GO:0048541 +name: Peyer's patch development +namespace: biological_process +def: "The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:add, ISBN:0781735149] +synonym: "GALT development" RELATED [] +synonym: "gut-associated lymphoid tissue development" RELATED [] +is_a: GO:0048537 ! mucosa-associated lymphoid tissue development + +[Term] +id: GO:0048542 +name: lymph gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages." [GOC:mtg_sensu, GOC:rc] +synonym: "haematopoietic organ development" BROAD [] +synonym: "haemopoietic organ development" BROAD [] +synonym: "hematopoietic organ development" BROAD [] +synonym: "hemopoietic organ development" BROAD [] +is_a: GO:0048534 ! hematopoietic or lymphoid organ development +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048543 +name: phytochrome chromophore biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form." [GOC:pj, PMID:2909515] +synonym: "phytochrome chromophore anabolism" EXACT [] +synonym: "phytochrome chromophore biosynthesis" EXACT [] +synonym: "phytochrome chromophore formation" EXACT [] +synonym: "phytochrome chromophore synthesis" EXACT [] +is_a: GO:0046148 ! pigment biosynthetic process + +[Term] +id: GO:0048544 +name: recognition of pollen +namespace: biological_process +alt_id: GO:0009857 +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species." [GOC:dph, GOC:pj, GOC:tb] +synonym: "pollen recognition" EXACT [] +synonym: "recognition or rejection of self pollen" RELATED [GOC:dph, GOC:tb] +synonym: "self incompatibility" RELATED [] +is_a: GO:0008037 ! cell recognition +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0048545 +name: response to steroid hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:go_curators] +synonym: "response to steroid hormone stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0048546 +name: digestive tract morphogenesis +namespace: biological_process +alt_id: GO:0048547 +def: "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:dph, GOC:go_curators, PMID:12618131] +synonym: "alimentary canal morphogenesis" EXACT [] +synonym: "digestive tube morphogenesis" EXACT [] +synonym: "gastrointestinal tract morphogenesis" EXACT [] +synonym: "gut morphogenesis" BROAD [GOC:dph] +synonym: "intestinal morphogenesis" NARROW [] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0048548 +name: regulation of pinocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048549 +name: positive regulation of pinocytosis +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +synonym: "activation of pinocytosis" NARROW [] +synonym: "stimulation of pinocytosis" NARROW [] +synonym: "up regulation of pinocytosis" EXACT [] +synonym: "up-regulation of pinocytosis" EXACT [] +synonym: "upregulation of pinocytosis" EXACT [] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0048548 ! regulation of pinocytosis +relationship: positively_regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048550 +name: negative regulation of pinocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pinocytosis. Pinocytosis is the process in which cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [GOC:go_curators] +synonym: "down regulation of pinocytosis" EXACT [] +synonym: "down-regulation of pinocytosis" EXACT [] +synonym: "downregulation of pinocytosis" EXACT [] +synonym: "inhibition of pinocytosis" NARROW [] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0048548 ! regulation of pinocytosis +relationship: negatively_regulates GO:0006907 ! pinocytosis + +[Term] +id: GO:0048555 +name: generative cell nucleus +namespace: cellular_component +def: "The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells." [GOC:tair_curators] +synonym: "male germ cell nucleus" BROAD [] +synonym: "sperm cell nucleus" BROAD [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048556 +name: microsporocyte nucleus +namespace: cellular_component +alt_id: GO:0043074 +def: "The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte." [GOC:tair_curators, ISBN:047186840X] +synonym: "microspore mother cell nucleus" EXACT [] +synonym: "pollen mother cell nucleus" EXACT [] +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0048557 +name: embryonic digestive tract morphogenesis +namespace: biological_process +alt_id: GO:0048558 +def: "The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] +synonym: "embryonic gut morphogenesis" BROAD [GOC:dph] +is_a: GO:0048562 ! embryonic organ morphogenesis +relationship: part_of GO:0048546 ! digestive tract morphogenesis +relationship: part_of GO:0048566 ! embryonic digestive tract development + +[Term] +id: GO:0048559 +name: establishment of floral organ orientation +namespace: biological_process +def: "The process that determines the orientation of the floral organs with reference to the central axis of the flower." [GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090707 ! establishment of plant organ orientation +relationship: part_of GO:0048439 ! flower morphogenesis + +[Term] +id: GO:0048560 +name: establishment of anatomical structure orientation +namespace: biological_process +def: "The process that determines the orientation of an anatomical structure with reference to an axis." [GOC:jid] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048561 +name: establishment of animal organ orientation +namespace: biological_process +def: "The process that determines the orientation of an animal organ or tissue with reference to an axis." [GOC:jid] +is_a: GO:0048560 ! establishment of anatomical structure orientation +relationship: part_of GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0048562 +name: embryonic organ morphogenesis +namespace: biological_process +def: "Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048568 ! embryonic organ development + +[Term] +id: GO:0048563 +name: post-embryonic animal organ morphogenesis +namespace: biological_process +def: "Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048569 ! post-embryonic animal organ development + +[Term] +id: GO:0048564 +name: photosystem I assembly +namespace: biological_process +alt_id: GO:0010251 +def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane." [GOC:go_curators] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0019684 ! photosynthesis, light reaction + +[Term] +id: GO:0048565 +name: digestive tract development +namespace: biological_process +def: "The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:go_curators] +synonym: "gut development" BROAD [GOC:dph] +synonym: "intestinal development" NARROW [] +synonym: "intestine development" NARROW [] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0055123 ! digestive system development + +[Term] +id: GO:0048566 +name: embryonic digestive tract development +namespace: biological_process +def: "The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus." [GOC:go_curators] +is_a: GO:0048565 ! digestive tract development +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0048567 +name: ectodermal digestive tract morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm." [GOC:jid] +synonym: "ectodermal gut morphogenesis" RELATED [GOC:dph] +is_a: GO:0007439 ! ectodermal digestive tract development +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0048568 +name: embryonic organ development +namespace: biological_process +def: "Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] +synonym: "embryonic organogenesis" EXACT [] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0048569 +name: post-embryonic animal organ development +namespace: biological_process +def: "Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:jid] +synonym: "post-embryonic animal organogenesis" EXACT [] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0048570 +name: notochord morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:jid] +is_a: GO:0048562 ! embryonic organ morphogenesis +relationship: part_of GO:0030903 ! notochord development + +[Term] +id: GO:0048571 +name: long-day photoperiodism +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "response to long-day" EXACT [] +synonym: "response to long-day photoperiod" RELATED [] +synonym: "response to short-night" EXACT [] +synonym: "short-night photoperiodism" EXACT [] +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0048572 +name: short-day photoperiodism +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "long-night photoperiodism" EXACT [] +synonym: "response to long-night" EXACT [] +synonym: "response to short-day" EXACT [] +synonym: "response to short-day photoperiod" RELATED [] +is_a: GO:0009648 ! photoperiodism + +[Term] +id: GO:0048573 +name: photoperiodism, flowering +namespace: biological_process +def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "photoperiodic control of flowering time" EXACT [] +synonym: "photoperiodic control of inflorescence development" EXACT [] +synonym: "response to day length, flowering" EXACT [] +synonym: "response to night length, flowering" EXACT [] +synonym: "response to photoperiod, flowering" EXACT [] +is_a: GO:0009648 ! photoperiodism +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0010228 ! vegetative to reproductive phase transition of meristem + +[Term] +id: GO:0048574 +name: long-day photoperiodism, flowering +namespace: biological_process +def: "A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "long-day photoperiodic control of flowering" EXACT [] +synonym: "long-day photoperiodic control of flowering time" EXACT [] +synonym: "long-day photoperiodic control of inflorescence development" EXACT [] +synonym: "response to long-day, flowering" EXACT [] +synonym: "response to short-night, flowering" EXACT [] +synonym: "short-night photoperiodism, flowering" EXACT [] +is_a: GO:0048571 ! long-day photoperiodism +is_a: GO:0048573 ! photoperiodism, flowering + +[Term] +id: GO:0048575 +name: short-day photoperiodism, flowering +namespace: biological_process +def: "A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "long-night photoperiodism, flowering" EXACT [] +synonym: "response to long-night, flowering" EXACT [] +synonym: "response to short-day, flowering" EXACT [] +synonym: "short-day photoperiodic control of flowering" EXACT [] +synonym: "short-day photoperiodic control of flowering time" EXACT [] +synonym: "short-day photoperiodic control of inflorescence development" EXACT [] +is_a: GO:0048572 ! short-day photoperiodism +is_a: GO:0048573 ! photoperiodism, flowering + +[Term] +id: GO:0048576 +name: positive regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "activation of short-day photoperiodism, flowering" NARROW [] +synonym: "stimulation of short-day photoperiodism, flowering" NARROW [] +synonym: "up regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "up-regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "upregulation of short-day photoperiodism, flowering" EXACT [] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048577 +name: negative regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "down regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "down-regulation of short-day photoperiodism, flowering" EXACT [] +synonym: "downregulation of short-day photoperiodism, flowering" EXACT [] +synonym: "inhibition of short-day photoperiodism, flowering" NARROW [] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0048587 ! regulation of short-day photoperiodism, flowering +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048578 +name: positive regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "activation of long-day photoperiodism, flowering" NARROW [] +synonym: "stimulation of long-day photoperiodism, flowering" NARROW [] +synonym: "up regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "up-regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "upregulation of long-day photoperiodism, flowering" EXACT [] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048579 +name: negative regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +synonym: "down regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "down-regulation of long-day photoperiodism, flowering" EXACT [] +synonym: "downregulation of long-day photoperiodism, flowering" EXACT [] +synonym: "inhibition of long-day photoperiodism, flowering" NARROW [] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0048586 ! regulation of long-day photoperiodism, flowering +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048580 +name: regulation of post-embryonic development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048581 +name: negative regulation of post-embryonic development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] +synonym: "down regulation of post-embryonic development" EXACT [] +synonym: "down-regulation of post-embryonic development" EXACT [] +synonym: "downregulation of post-embryonic development" EXACT [] +synonym: "inhibition of post-embryonic development" NARROW [] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048582 +name: positive regulation of post-embryonic development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure." [GOC:jid] +synonym: "activation of post-embryonic development" NARROW [] +synonym: "stimulation of post-embryonic development" NARROW [] +synonym: "up regulation of post-embryonic development" EXACT [] +synonym: "up-regulation of post-embryonic development" EXACT [] +synonym: "upregulation of post-embryonic development" EXACT [] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0009791 ! post-embryonic development + +[Term] +id: GO:0048583 +name: regulation of response to stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048584 +name: positive regulation of response to stimulus +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "activation of response to stimulus" NARROW [] +synonym: "stimulation of response to stimulus" NARROW [] +synonym: "up regulation of response to stimulus" EXACT [] +synonym: "up-regulation of response to stimulus" EXACT [] +synonym: "upregulation of response to stimulus" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: positively_regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048585 +name: negative regulation of response to stimulus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "down regulation of response to stimulus" EXACT [] +synonym: "down-regulation of response to stimulus" EXACT [] +synonym: "downregulation of response to stimulus" EXACT [] +synonym: "inhibition of response to stimulus" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: negatively_regulates GO:0050896 ! response to stimulus + +[Term] +id: GO:0048586 +name: regulation of long-day photoperiodism, flowering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +is_a: GO:2000028 ! regulation of photoperiodism, flowering +relationship: regulates GO:0048574 ! long-day photoperiodism, flowering + +[Term] +id: GO:0048587 +name: regulation of short-day photoperiodism, flowering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] +is_a: GO:2000028 ! regulation of photoperiodism, flowering +relationship: regulates GO:0048575 ! short-day photoperiodism, flowering + +[Term] +id: GO:0048588 +name: developmental cell growth +namespace: biological_process +def: "The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another." [GOC:go_curators, GOC:isa_complete] +synonym: "developmental growth of a unicellular organism" EXACT [] +is_a: GO:0016049 ! cell growth +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048468 ! cell development + +[Term] +id: GO:0048589 +name: developmental growth +namespace: biological_process +def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] +is_a: GO:0032502 ! developmental process +is_a: GO:0040007 ! growth + +[Term] +id: GO:0048592 +name: eye morphogenesis +namespace: biological_process +alt_id: GO:0048748 +def: "The process in which the anatomical structures of the eye are generated and organized." [GOC:jid, GOC:mtg_sensu] +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0001654 ! eye development + +[Term] +id: GO:0048593 +name: camera-type eye morphogenesis +namespace: biological_process +alt_id: GO:0048594 +alt_id: GO:0048595 +def: "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:jid, GOC:mtg_sensu] +synonym: "camera-style eye morphogenesis" EXACT [GOC:dph] +is_a: GO:0048592 ! eye morphogenesis +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0048596 +name: embryonic camera-type eye morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the eye are generated and organized during embryonic development." [GOC:jid, GOC:mtg_sensu] +synonym: "embryonic eye morphogenesis" BROAD [] +is_a: GO:0048048 ! embryonic eye morphogenesis +relationship: part_of GO:0031076 ! embryonic camera-type eye development +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0048597 +name: post-embryonic camera-type eye morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the eye are generated and organized during post-embryonic development." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] +synonym: "post-embryonic camera-style eye morphogenesis" EXACT [] +synonym: "post-embryonic eye morphogenesis" BROAD [] +is_a: GO:0048050 ! post-embryonic eye morphogenesis +relationship: part_of GO:0031077 ! post-embryonic camera-type eye development +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0048598 +name: embryonic morphogenesis +namespace: biological_process +alt_id: GO:0048828 +def: "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants." [GOC:jid, GOC:mtg_sensu] +synonym: "embryonic anatomical structure morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0048599 +name: oocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:go_curators] +is_a: GO:0007281 ! germ cell development +relationship: part_of GO:0009994 ! oocyte differentiation + +[Term] +id: GO:0048600 +name: oocyte fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte." [GOC:go_curators] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0009994 ! oocyte differentiation + +[Term] +id: GO:0048601 +name: oocyte morphogenesis +namespace: biological_process +def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] +synonym: "oocyte morphogenesis during differentiation" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0048599 ! oocyte development + +[Term] +id: GO:0048608 +name: reproductive structure development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061458 ! reproductive system development + +[Term] +id: GO:0048609 +name: multicellular organismal reproductive process +namespace: biological_process +def: "The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs." [GOC:dph, GOC:jid, GOC:tb] +synonym: "organismal reproductive process" BROAD [] +synonym: "reproductive process in a multicellular organism" EXACT [] +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0032504 ! multicellular organism reproduction + +[Term] +id: GO:0048610 +name: obsolete cellular process involved in reproduction +namespace: biological_process +def: "OBSOLETE. A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism." [GOC:dph, GOC:jid] +comment: This process was made obsolete because we felt it not provide a particularly useful classification, and its very broad logical definition caused regular problems in our inference pipelines. +synonym: "cellular process involved in reproduction" EXACT [] +synonym: "reproductive cellular process" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0048611 +name: embryonic ectodermal digestive tract development +namespace: biological_process +def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] +synonym: "embryonic ectodermal gut development" RELATED [GOC:dph] +is_a: GO:0048566 ! embryonic digestive tract development +relationship: part_of GO:0007439 ! ectodermal digestive tract development + +[Term] +id: GO:0048612 +name: post-embryonic ectodermal digestive tract development +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure." [GOC:jid, GOC:rc] +synonym: "post-embryonic ectodermal gut development" RELATED [GOC:dph] +is_a: GO:0048569 ! post-embryonic animal organ development +relationship: part_of GO:0007439 ! ectodermal digestive tract development + +[Term] +id: GO:0048613 +name: embryonic ectodermal digestive tract morphogenesis +namespace: biological_process +def: "The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized." [GOC:jid, GOC:rc] +synonym: "embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048557 ! embryonic digestive tract morphogenesis +relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis +relationship: part_of GO:0048611 ! embryonic ectodermal digestive tract development + +[Term] +id: GO:0048614 +name: post-embryonic ectodermal digestive tract morphogenesis +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized." [GOC:jid, GOC:rc] +synonym: "post-embryonic ectodermal gut morphogenesis" RELATED [GOC:dph] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis +relationship: part_of GO:0048612 ! post-embryonic ectodermal digestive tract development +relationship: part_of GO:0048621 ! post-embryonic digestive tract morphogenesis + +[Term] +id: GO:0048615 +name: embryonic anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis +relationship: part_of GO:0048613 ! embryonic ectodermal digestive tract morphogenesis + +[Term] +id: GO:0048616 +name: post-embryonic anterior midgut (ectodermal) morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007441 ! anterior midgut (ectodermal) morphogenesis +relationship: part_of GO:0048614 ! post-embryonic ectodermal digestive tract morphogenesis + +[Term] +id: GO:0048617 +name: embryonic foregut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007440 ! foregut morphogenesis + +[Term] +id: GO:0048618 +name: post-embryonic foregut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007440 ! foregut morphogenesis + +[Term] +id: GO:0048619 +name: embryonic hindgut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007442 ! hindgut morphogenesis + +[Term] +id: GO:0048620 +name: post-embryonic hindgut morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." [GOC:jid, GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007442 ! hindgut morphogenesis + +[Term] +id: GO:0048621 +name: post-embryonic digestive tract morphogenesis +namespace: biological_process +def: "The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:jid, GOC:rc] +synonym: "post-embryonic gut morphogenesis" BROAD [GOC:dph] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0048622 +name: obsolete reproductive sporulation +namespace: biological_process +def: "OBSOLETE. The formation of reproductive spores." [GOC:jid] +comment: This term was made obsolete because it was ambiguously defined and incorrectly placed in the ontology. +synonym: "reproductive sporulation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048623 +name: seed germination on parent plant +namespace: biological_process +def: "The process in which a seed germinates before being shed from the parent plant." [GOC:go_curators] +synonym: "non-vegetative vivipary" BROAD [] +synonym: "pre-harvest sprouting" EXACT [] +synonym: "vivipary" BROAD [] +is_a: GO:0009845 ! seed germination + +[Term] +id: GO:0048624 +name: plantlet formation on parent plant +namespace: biological_process +def: "The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed." [GOC:go_curators] +synonym: "vegetative vivipary" BROAD [] +synonym: "vivipary" BROAD [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048507 ! meristem development +is_a: GO:0048609 ! multicellular organismal reproductive process + +[Term] +id: GO:0048625 +name: myoblast fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0048626 +name: myoblast fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048625 ! myoblast fate commitment + +[Term] +id: GO:0048627 +name: myoblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0048628 +name: myoblast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:dph, GOC:mtg_muscle] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0048627 ! myoblast development + +[Term] +id: GO:0048629 +name: trichome patterning +namespace: biological_process +def: "The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes." [GOC:jid, GOC:mtg_sensu, GOC:sm, GOC:tb, ISBN:0865427429, PMID:10368181] +synonym: "trichome distribution" BROAD [] +synonym: "trichome pattern biosynthesis" EXACT [] +synonym: "trichome pattern formation" EXACT [] +synonym: "trichome pattern specification" RELATED [] +synonym: "trichome spacing" EXACT [] +is_a: GO:0003002 ! regionalization +is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment +relationship: part_of GO:0010026 ! trichome differentiation + +[Term] +id: GO:0048630 +name: skeletal muscle tissue growth +namespace: biological_process +def: "The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size." [GOC:lm, PMID:15726494, PMID:15907921] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0048631 +name: regulation of skeletal muscle tissue growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0048630 ! skeletal muscle tissue growth + +[Term] +id: GO:0048632 +name: negative regulation of skeletal muscle tissue growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +synonym: "down regulation of skeletal muscle growth" EXACT [] +synonym: "down-regulation of skeletal muscle growth" EXACT [] +synonym: "downregulation of skeletal muscle growth" EXACT [] +synonym: "inhibition of skeletal muscle growth" NARROW [] +is_a: GO:0048631 ! regulation of skeletal muscle tissue growth +is_a: GO:0048640 ! negative regulation of developmental growth +relationship: negatively_regulates GO:0048630 ! skeletal muscle tissue growth + +[Term] +id: GO:0048633 +name: positive regulation of skeletal muscle tissue growth +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle growth." [GOC:lm, PMID:15726494, PMID:15907921] +synonym: "activation of skeletal muscle growth" NARROW [] +synonym: "stimulation of skeletal muscle growth" NARROW [] +synonym: "up regulation of skeletal muscle growth" EXACT [] +synonym: "up-regulation of skeletal muscle growth" EXACT [] +synonym: "upregulation of skeletal muscle growth" EXACT [] +is_a: GO:0048631 ! regulation of skeletal muscle tissue growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development +relationship: positively_regulates GO:0048630 ! skeletal muscle tissue growth + +[Term] +id: GO:0048634 +name: regulation of muscle organ development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle development." [GOC:go_curators] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0007517 ! muscle organ development + +[Term] +id: GO:0048635 +name: negative regulation of muscle organ development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development." [GOC:go_curators] +synonym: "down regulation of muscle development" EXACT [] +synonym: "down-regulation of muscle development" EXACT [] +synonym: "downregulation of muscle development" EXACT [] +synonym: "inhibition of muscle development" NARROW [] +is_a: GO:0048634 ! regulation of muscle organ development +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007517 ! muscle organ development + +[Term] +id: GO:0048636 +name: positive regulation of muscle organ development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of muscle development." [GOC:go_curators] +synonym: "activation of muscle development" NARROW [] +synonym: "stimulation of muscle development" NARROW [] +synonym: "up regulation of muscle development" EXACT [] +synonym: "up-regulation of muscle development" EXACT [] +synonym: "upregulation of muscle development" EXACT [] +is_a: GO:0048634 ! regulation of muscle organ development +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007517 ! muscle organ development + +[Term] +id: GO:0048638 +name: regulation of developmental growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] +is_a: GO:0040008 ! regulation of growth +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048639 +name: positive regulation of developmental growth +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] +synonym: "activation of developmental growth" NARROW [] +synonym: "stimulation of developmental growth" NARROW [] +synonym: "up regulation of developmental growth" EXACT [] +synonym: "up-regulation of developmental growth" EXACT [] +synonym: "upregulation of developmental growth" EXACT [] +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048640 +name: negative regulation of developmental growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth." [GOC:go_curators] +synonym: "down regulation of developmental growth" EXACT [] +synonym: "down-regulation of developmental growth" EXACT [] +synonym: "downregulation of developmental growth" EXACT [] +synonym: "inhibition of developmental growth" NARROW [] +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0048589 ! developmental growth + +[Term] +id: GO:0048641 +name: regulation of skeletal muscle tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] +is_a: GO:0016202 ! regulation of striated muscle tissue development +relationship: regulates GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0048642 +name: negative regulation of skeletal muscle tissue development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development." [GOC:go_curators] +synonym: "down regulation of skeletal muscle development" EXACT [] +synonym: "down-regulation of skeletal muscle development" EXACT [] +synonym: "downregulation of skeletal muscle development" EXACT [] +synonym: "inhibition of skeletal muscle development" NARROW [] +is_a: GO:0045843 ! negative regulation of striated muscle tissue development +is_a: GO:0048641 ! regulation of skeletal muscle tissue development +relationship: negatively_regulates GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0048643 +name: positive regulation of skeletal muscle tissue development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle tissue development." [GOC:go_curators] +synonym: "activation of skeletal muscle development" NARROW [] +synonym: "stimulation of skeletal muscle development" NARROW [] +synonym: "up regulation of skeletal muscle development" EXACT [] +synonym: "up-regulation of skeletal muscle development" EXACT [] +synonym: "upregulation of skeletal muscle development" EXACT [] +is_a: GO:0045844 ! positive regulation of striated muscle tissue development +is_a: GO:0048641 ! regulation of skeletal muscle tissue development +relationship: positively_regulates GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0048644 +name: muscle organ morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of muscle are generated and organized." [GOC:jid] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0007517 ! muscle organ development + +[Term] +id: GO:0048645 +name: animal organ formation +namespace: biological_process +def: "The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ." [GOC:dph, GOC:jid] +synonym: "animal organ primordium initiation" NARROW [] +synonym: "initiation of an animal organ primordium" NARROW [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0048646 +name: anatomical structure formation involved in morphogenesis +namespace: biological_process +def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] +comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. +subset: goslim_chembl +synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0048647 +name: polyphenic determination +namespace: biological_process +def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues." [GOC:jid] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0048648 +name: caste determination +namespace: biological_process +def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048649 +name: caste determination, influence by genetic factors +namespace: biological_process +def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] +is_a: GO:0048648 ! caste determination +is_a: GO:0048652 ! polyphenic determination, influence by genetic factors + +[Term] +id: GO:0048650 +name: caste determination, influence by environmental factors +namespace: biological_process +def: "The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects." [GOC:jid] +is_a: GO:0048648 ! caste determination +is_a: GO:0048651 ! polyphenic determination, influence by environmental factors + +[Term] +id: GO:0048651 +name: polyphenic determination, influence by environmental factors +namespace: biological_process +def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues." [GOC:jid] +is_a: GO:0009605 ! response to external stimulus +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048652 +name: polyphenic determination, influence by genetic factors +namespace: biological_process +def: "The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues." [GOC:jid] +is_a: GO:0048647 ! polyphenic determination + +[Term] +id: GO:0048653 +name: anther development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure." [GOC:jid, GOC:sm] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048443 ! stamen development + +[Term] +id: GO:0048654 +name: anther morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anther are generated and organized." [GOC:jid, GOC:sm] +is_a: GO:0048444 ! floral organ morphogenesis +relationship: part_of GO:0048448 ! stamen morphogenesis +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0048655 +name: anther wall tapetum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb] +synonym: "differentiation of tapetal layer" NARROW [] +synonym: "tapetal layer morphogenesis" BROAD [GOC:tb] +synonym: "tapetum morphogenesis" BROAD [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0048654 ! anther morphogenesis +relationship: part_of GO:0048658 ! anther wall tapetum development + +[Term] +id: GO:0048656 +name: anther wall tapetum formation +namespace: biological_process +def: "The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm, GOC:tb] +synonym: "tapetal layer formation" BROAD [GOC:tb] +synonym: "tapetum formation" BROAD [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048455 ! stamen formation +relationship: part_of GO:0048655 ! anther wall tapetum morphogenesis + +[Term] +id: GO:0048657 +name: anther wall tapetum cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." [GOC:jid, GOC:sm] +synonym: "tapetal cell differentiation" BROAD [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048656 ! anther wall tapetum formation + +[Term] +id: GO:0048658 +name: anther wall tapetum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure." [GOC:jid, GOC:sm, GOC:tb] +synonym: "tapetal layer development" BROAD [GOC:tb] +synonym: "tapetum development" BROAD [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0048659 +name: smooth muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population." [CL:0000192, GOC:ebc, PMID:1840698] +synonym: "SMC proliferation" EXACT [] +is_a: GO:0033002 ! muscle cell proliferation + +[Term] +id: GO:0048660 +name: regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "regulation of SMC proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048661 +name: positive regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "activation of smooth muscle cell proliferation" NARROW [] +synonym: "positive regulation of SMC proliferation" EXACT [] +synonym: "stimulation of smooth muscle cell proliferation" NARROW [] +synonym: "up regulation of smooth muscle cell proliferation" EXACT [] +synonym: "up-regulation of smooth muscle cell proliferation" EXACT [] +synonym: "upregulation of smooth muscle cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0048660 ! regulation of smooth muscle cell proliferation +relationship: positively_regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048662 +name: negative regulation of smooth muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation." [CL:0000192, GOC:ebc] +synonym: "down regulation of smooth muscle cell proliferation" EXACT [] +synonym: "down-regulation of smooth muscle cell proliferation" EXACT [] +synonym: "downregulation of smooth muscle cell proliferation" EXACT [] +synonym: "inhibition of smooth muscle cell proliferation" NARROW [] +synonym: "negative regulation of SMC proliferation" EXACT [] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0048660 ! regulation of smooth muscle cell proliferation +relationship: negatively_regulates GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:0048663 +name: neuron fate commitment +namespace: biological_process +alt_id: GO:0042055 +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron." [GOC:dph] +synonym: "neuron lineage restriction" EXACT [] +synonym: "neuronal lineage restriction" EXACT [] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030182 ! neuron differentiation + +[Term] +id: GO:0048664 +name: neuron fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dph] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048663 ! neuron fate commitment + +[Term] +id: GO:0048665 +name: neuron fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:dph] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048663 ! neuron fate commitment + +[Term] +id: GO:0048666 +name: neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030182 ! neuron differentiation + +[Term] +id: GO:0048667 +name: cell morphogenesis involved in neuron differentiation +namespace: biological_process +def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] +synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0048666 ! neuron development + +[Term] +id: GO:0048668 +name: collateral sprouting +namespace: biological_process +def: "The process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "axon branching" BROAD [GOC:BHF, PMID:21463686] +is_a: GO:0048588 ! developmental cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0048669 +name: collateral sprouting in absence of injury +namespace: biological_process +def: "The process in which outgrowths develop from the axons of intact undamaged neurons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048670 +name: regulation of collateral sprouting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0050770 ! regulation of axonogenesis +is_a: GO:0061387 ! regulation of extent of cell growth +relationship: regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048671 +name: negative regulation of collateral sprouting +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of collateral sprouting" EXACT [] +synonym: "down-regulation of collateral sprouting" EXACT [] +synonym: "downregulation of collateral sprouting" EXACT [] +synonym: "inhibition of collateral sprouting" NARROW [] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0050771 ! negative regulation of axonogenesis +relationship: negatively_regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048672 +name: positive regulation of collateral sprouting +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of collateral sprouting" NARROW [] +synonym: "stimulation of collateral sprouting" NARROW [] +synonym: "up regulation of collateral sprouting" EXACT [] +synonym: "up-regulation of collateral sprouting" EXACT [] +synonym: "upregulation of collateral sprouting" EXACT [] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0050772 ! positive regulation of axonogenesis +relationship: positively_regulates GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048673 +name: collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input." [GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0031103 ! axon regeneration +is_a: GO:0048668 ! collateral sprouting + +[Term] +id: GO:0048674 +name: collateral sprouting of injured axon +namespace: biological_process +def: "The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048668 ! collateral sprouting +is_a: GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048675 +name: axon extension +namespace: biological_process +alt_id: GO:0048676 +def: "Long distance growth of a single axon process involved in cellular development." [GOC:BHF, GOC:dgh, GOC:dph, GOC:jid, GOC:lm, GOC:rl] +synonym: "axon extension involved in development" EXACT [] +is_a: GO:1990138 ! neuron projection extension +relationship: part_of GO:0007409 ! axonogenesis + +[Term] +id: GO:0048677 +name: axon extension involved in regeneration +namespace: biological_process +def: "Long distance growth of a single axon process involved in regeneration of the neuron." [GOC:jid] +is_a: GO:0048675 ! axon extension +is_a: GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048678 +name: response to axon injury +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0048679 +name: regulation of axon regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0070570 ! regulation of neuron projection regeneration +is_a: GO:1903034 ! regulation of response to wounding +relationship: regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048680 +name: positive regulation of axon regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of axon regeneration" NARROW [] +synonym: "stimulation of axon regeneration" NARROW [] +synonym: "up regulation of axon regeneration" EXACT [] +synonym: "up-regulation of axon regeneration" EXACT [] +synonym: "upregulation of axon regeneration" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0048679 ! regulation of axon regeneration +is_a: GO:0070572 ! positive regulation of neuron projection regeneration +is_a: GO:1903036 ! positive regulation of response to wounding +relationship: positively_regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048681 +name: negative regulation of axon regeneration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of axon regeneration" EXACT [] +synonym: "down-regulation of axon regeneration" EXACT [] +synonym: "downregulation of axon regeneration" EXACT [] +synonym: "inhibition of axon regeneration" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0048679 ! regulation of axon regeneration +is_a: GO:0070571 ! negative regulation of neuron projection regeneration +is_a: GO:1903035 ! negative regulation of response to wounding +relationship: negatively_regulates GO:0031103 ! axon regeneration + +[Term] +id: GO:0048682 +name: sprouting of injured axon +namespace: biological_process +def: "The process involved in sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048588 ! developmental cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0031103 ! axon regeneration + +[Term] +id: GO:0048683 +name: regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0048679 ! regulation of axon regeneration +relationship: regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048684 +name: positive regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of collateral sprouting of intact axon in response to injury" NARROW [] +synonym: "stimulation of collateral sprouting of intact axon in response to injury" NARROW [] +synonym: "up regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "up-regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "upregulation of collateral sprouting of intact axon in response to injury" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048680 ! positive regulation of axon regeneration +is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury +relationship: positively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048685 +name: negative regulation of collateral sprouting of intact axon in response to injury +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an intact axon as a result of injury to an axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "down-regulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "downregulation of collateral sprouting of intact axon in response to injury" EXACT [] +synonym: "inhibition of collateral sprouting of intact axon in response to injury" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048681 ! negative regulation of axon regeneration +is_a: GO:0048683 ! regulation of collateral sprouting of intact axon in response to injury +relationship: negatively_regulates GO:0048673 ! collateral sprouting of intact axon in response to injury + +[Term] +id: GO:0048686 +name: regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0061387 ! regulation of extent of cell growth +relationship: regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048687 +name: positive regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of sprouting of injured axon" NARROW [] +synonym: "stimulation of sprouting of injured axon" NARROW [] +synonym: "up regulation of sprouting of injured axon" EXACT [] +synonym: "up-regulation of sprouting of injured axon" EXACT [] +synonym: "upregulation of sprouting of injured axon" EXACT [] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0048680 ! positive regulation of axon regeneration +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: positively_regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048688 +name: negative regulation of sprouting of injured axon +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of sprouting of injured axon" EXACT [] +synonym: "down-regulation of sprouting of injured axon" EXACT [] +synonym: "downregulation of sprouting of injured axon" EXACT [] +synonym: "inhibition of sprouting of injured axon" NARROW [] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0048681 ! negative regulation of axon regeneration +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: negatively_regulates GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048689 +name: formation of growth cone in injured axon +namespace: biological_process +def: "The formation of a growth cone in an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048682 ! sprouting of injured axon + +[Term] +id: GO:0048690 +name: regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0030516 ! regulation of axon extension +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048691 +name: positive regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of axon extension involved in regeneration" NARROW [] +synonym: "stimulation of axon extension involved in regeneration" NARROW [] +synonym: "up regulation of axon extension involved in regeneration" EXACT [] +synonym: "up-regulation of axon extension involved in regeneration" EXACT [] +synonym: "upregulation of axon extension involved in regeneration" EXACT [] +is_a: GO:0045773 ! positive regulation of axon extension +is_a: GO:0048687 ! positive regulation of sprouting of injured axon +is_a: GO:0048690 ! regulation of axon extension involved in regeneration +relationship: positively_regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048692 +name: negative regulation of axon extension involved in regeneration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in regeneration." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of axon extension involved in regeneration" EXACT [] +synonym: "down-regulation of axon extension involved in regeneration" EXACT [] +synonym: "downregulation of axon extension involved in regeneration" EXACT [] +synonym: "inhibition of axon extension involved in regeneration" NARROW [] +is_a: GO:0030517 ! negative regulation of axon extension +is_a: GO:0048688 ! negative regulation of sprouting of injured axon +is_a: GO:0048690 ! regulation of axon extension involved in regeneration +relationship: negatively_regulates GO:0048677 ! axon extension involved in regeneration + +[Term] +id: GO:0048693 +name: regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048694 +name: positive regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of collateral sprouting of injured axon" NARROW [] +synonym: "stimulation of collateral sprouting of injured axon" NARROW [] +synonym: "up regulation of collateral sprouting of injured axon" EXACT [] +synonym: "up-regulation of collateral sprouting of injured axon" EXACT [] +synonym: "upregulation of collateral sprouting of injured axon" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048687 ! positive regulation of sprouting of injured axon +is_a: GO:0048693 ! regulation of collateral sprouting of injured axon +relationship: positively_regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048695 +name: negative regulation of collateral sprouting of injured axon +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting of an injured axon." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of collateral sprouting of injured axon" EXACT [] +synonym: "down-regulation of collateral sprouting of injured axon" EXACT [] +synonym: "downregulation of collateral sprouting of injured axon" EXACT [] +synonym: "inhibition of collateral sprouting of injured axon" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048688 ! negative regulation of sprouting of injured axon +is_a: GO:0048693 ! regulation of collateral sprouting of injured axon +relationship: negatively_regulates GO:0048674 ! collateral sprouting of injured axon + +[Term] +id: GO:0048696 +name: regulation of collateral sprouting in absence of injury +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0048670 ! regulation of collateral sprouting +relationship: regulates GO:0048669 ! collateral sprouting in absence of injury + +[Term] +id: GO:0048697 +name: positive regulation of collateral sprouting in absence of injury +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "activation of collateral sprouting in the absence of injury" NARROW [] +synonym: "stimulation of collateral sprouting in the absence of injury" NARROW [] +synonym: "up regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "up-regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "upregulation of collateral sprouting in the absence of injury" EXACT [] +is_a: GO:0048672 ! positive regulation of collateral sprouting +is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury +relationship: positively_regulates GO:0048669 ! collateral sprouting in absence of injury + +[Term] +id: GO:0048698 +name: negative regulation of collateral sprouting in absence of injury +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting in the absence of injury." [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] +synonym: "down regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "down-regulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "downregulation of collateral sprouting in the absence of injury" EXACT [] +synonym: "inhibition of collateral sprouting in the absence of injury" NARROW [] +is_a: GO:0048671 ! negative regulation of collateral sprouting +is_a: GO:0048696 ! regulation of collateral sprouting in absence of injury +relationship: negatively_regulates GO:0048669 ! collateral sprouting in absence of injury + +[Term] +id: GO:0048699 +name: generation of neurons +namespace: biological_process +def: "The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons." [GOC:nln] +synonym: "neuron generation" EXACT [] +is_a: GO:0022008 ! neurogenesis + +[Term] +id: GO:0048700 +name: acquisition of desiccation tolerance in seed +namespace: biological_process +def: "The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state." [GOC:jid, GOC:ki, GOC:PO_curators, ISBN:9781405139830] +synonym: "acquisition of desiccation tolerance" BROAD [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0097439 ! acquisition of desiccation tolerance +relationship: part_of GO:0010162 ! seed dormancy process + +[Term] +id: GO:0048701 +name: embryonic cranial skeleton morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase." [GOC:dsf, GOC:jid, PMID:16049113] +synonym: "embryonic cranium morphogenesis" EXACT [] +is_a: GO:0048704 ! embryonic skeletal system morphogenesis +relationship: part_of GO:1904888 ! cranial skeletal system development + +[Term] +id: GO:0048702 +name: embryonic neurocranium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain." [GOC:dsf, GOC:jid, PMID:16049113] +synonym: "embryonic braincase morphogenesis" EXACT [] +synonym: "embryonic chondrocranium morphogenesis" EXACT [GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis + +[Term] +id: GO:0048703 +name: embryonic viscerocranium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones." [GOC:dsf, GOC:jid, PMID:16049113] +synonym: "embryonic pharyngeal skeleton morphogenesis" EXACT [] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048701 ! embryonic cranial skeleton morphogenesis + +[Term] +id: GO:0048704 +name: embryonic skeletal system morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] +synonym: "embryonic skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0048562 ! embryonic organ morphogenesis +is_a: GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0048706 ! embryonic skeletal system development + +[Term] +id: GO:0048705 +name: skeletal system morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the skeleton are generated and organized." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb] +synonym: "skeletal morphogenesis" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0001501 ! skeletal system development + +[Term] +id: GO:0048706 +name: embryonic skeletal system development +namespace: biological_process +def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure." [GOC:dph, GOC:dsf, GOC:jid, GOC:tb, PMID:16049113] +synonym: "embryonic skeletal development" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001501 ! skeletal system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0048707 +name: instar larval or pupal morphogenesis +namespace: biological_process +def: "The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized." [GOC:mtg_sensu, GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0002165 ! instar larval or pupal development + +[Term] +id: GO:0048708 +name: astrocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:vp, PMID:15139015] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0048709 +name: oligodendrocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0048710 +name: regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048711 +name: positive regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "activation of astrocyte differentiation" NARROW [] +synonym: "stimulation of astrocyte differentiation" NARROW [] +synonym: "up regulation of astrocyte differentiation" EXACT [] +synonym: "up-regulation of astrocyte differentiation" EXACT [] +synonym: "upregulation of astrocyte differentiation" EXACT [] +is_a: GO:0045687 ! positive regulation of glial cell differentiation +is_a: GO:0048710 ! regulation of astrocyte differentiation +relationship: positively_regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048712 +name: negative regulation of astrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "down regulation of astrocyte differentiation" EXACT [] +synonym: "down-regulation of astrocyte differentiation" EXACT [] +synonym: "downregulation of astrocyte differentiation" EXACT [] +synonym: "inhibition of astrocyte differentiation" NARROW [] +is_a: GO:0045686 ! negative regulation of glial cell differentiation +is_a: GO:0048710 ! regulation of astrocyte differentiation +relationship: negatively_regulates GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0048713 +name: regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +is_a: GO:0045685 ! regulation of glial cell differentiation +relationship: regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048714 +name: positive regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "activation of oligodendrocyte differentiation" NARROW [] +synonym: "stimulation of oligodendrocyte differentiation" NARROW [] +synonym: "up regulation of oligodendrocyte differentiation" EXACT [] +synonym: "up-regulation of oligodendrocyte differentiation" EXACT [] +synonym: "upregulation of oligodendrocyte differentiation" EXACT [] +is_a: GO:0045687 ! positive regulation of glial cell differentiation +is_a: GO:0048713 ! regulation of oligodendrocyte differentiation +relationship: positively_regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048715 +name: negative regulation of oligodendrocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015] +synonym: "down regulation of oligodendrocyte differentiation" EXACT [] +synonym: "down-regulation of oligodendrocyte differentiation" EXACT [] +synonym: "downregulation of oligodendrocyte differentiation" EXACT [] +synonym: "inhibition of oligodendrocyte differentiation" NARROW [] +is_a: GO:0045686 ! negative regulation of glial cell differentiation +is_a: GO:0048713 ! regulation of oligodendrocyte differentiation +relationship: negatively_regulates GO:0048709 ! oligodendrocyte differentiation + +[Term] +id: GO:0048716 +name: labrum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of labrum are generated and organized." [GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048726 ! labrum development + +[Term] +id: GO:0048717 +name: anterior cibarial plate morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048722 ! anterior cibarial plate development + +[Term] +id: GO:0048718 +name: cibarial fish-trap bristle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc] +synonym: "fish trap bristle morphogenesis" RELATED [GOC:rc] +is_a: GO:0008407 ! chaeta morphogenesis +is_a: GO:0048563 ! post-embryonic animal organ morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048725 ! cibarial fish-trap bristle development + +[Term] +id: GO:0048719 +name: epistomal sclerite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048724 ! epistomal sclerite development + +[Term] +id: GO:0048720 +name: posterior cibarial plate morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048727 ! posterior cibarial plate development + +[Term] +id: GO:0048721 +name: clypeus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis +relationship: part_of GO:0048723 ! clypeus development + +[Term] +id: GO:0048722 +name: anterior cibarial plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048723 +name: clypeus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048724 +name: epistomal sclerite development +namespace: biological_process +def: "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048725 +name: cibarial fish-trap bristle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc] +synonym: "fish-trap bristle development" EXACT [GOC:rc] +is_a: GO:0022416 ! chaeta development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048726 +name: labrum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048727 +name: posterior cibarial plate development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048728 +name: proboscis development +namespace: biological_process +alt_id: GO:0016349 +def: "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0035213 ! clypeo-labral disc development + +[Term] +id: GO:0048729 +name: tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0009888 ! tissue development + +[Term] +id: GO:0048730 +name: epidermis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003] +synonym: "hypodermis morphogenesis" RELATED [GOC:kmv, GOC:rk] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0008544 ! epidermis development + +[Term] +id: GO:0048731 +name: system development +namespace: biological_process +def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] +subset: goslim_mouse +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0048732 +name: gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0048733 +name: sebaceous gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0048734 +name: proboscis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048728 ! proboscis development + +[Term] +id: GO:0048735 +name: haltere morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc] +is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis +is_a: GO:0035120 ! post-embryonic appendage morphogenesis +relationship: part_of GO:0007481 ! haltere disc morphogenesis +relationship: part_of GO:0007482 ! haltere development + +[Term] +id: GO:0048736 +name: appendage development +namespace: biological_process +def: "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007275 ! multicellular organism development + +[Term] +id: GO:0048737 +name: imaginal disc-derived appendage development +namespace: biological_process +def: "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc] +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0048738 +name: cardiac muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] +synonym: "heart muscle development" EXACT [] +is_a: GO:0014706 ! striated muscle tissue development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0048740 +name: obsolete striated muscle fiber development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] +comment: This term was made obsolete because it was an unnecessary grouping term. Striated muscle comprises skeletal and cardiac muscle, but GO has opted not to group the muscle fiber development terms. +synonym: "myogenesis" EXACT [] +synonym: "striated muscle fiber development" EXACT [] +synonym: "striated muscle fibre development" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048741 +name: skeletal muscle fiber development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle] +synonym: "skeletal muscle fibre development" EXACT [] +synonym: "skeletal myofiber development" EXACT [] +synonym: "skeletal myofibre development" EXACT [] +is_a: GO:0014904 ! myotube cell development +relationship: part_of GO:0007519 ! skeletal muscle tissue development + +[Term] +id: GO:0048742 +name: regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm] +synonym: "regulation of skeletal muscle fibre development" EXACT [] +synonym: "regulation of skeletal myofiber development" EXACT [] +synonym: "regulation of skeletal myofibre development" EXACT [] +is_a: GO:0010830 ! regulation of myotube differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0048743 +name: positive regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] +synonym: "activation of skeletal muscle fiber development" NARROW [] +synonym: "positive regulation of skeletal muscle fibre development" EXACT [] +synonym: "positive regulation of skeletal myofiber development" EXACT [] +synonym: "positive regulation of skeletal myofibre development" EXACT [] +synonym: "stimulation of skeletal muscle fiber development" NARROW [] +synonym: "up regulation of skeletal muscle fiber development" EXACT [] +synonym: "up-regulation of skeletal muscle fiber development" EXACT [] +synonym: "upregulation of skeletal muscle fiber development" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation +relationship: positively_regulates GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0048744 +name: negative regulation of skeletal muscle fiber development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] +synonym: "down regulation of skeletal muscle fiber development" EXACT [] +synonym: "down-regulation of skeletal muscle fiber development" EXACT [] +synonym: "downregulation of skeletal muscle fiber development" EXACT [] +synonym: "inhibition of skeletal muscle fiber development" NARROW [] +synonym: "negative regulation of skeletal muscle fibre development" EXACT [] +synonym: "negative regulation of skeletal myofiber development" EXACT [] +synonym: "negative regulation of skeletal myofibre development" EXACT [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0048742 ! regulation of skeletal muscle fiber development +is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation +relationship: negatively_regulates GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0048745 +name: smooth muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm] +is_a: GO:0060537 ! muscle tissue development + +[Term] +id: GO:0048746 +name: obsolete smooth muscle fiber development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle] +comment: This term was made obsolete because smooth muscle does not have fibers. +synonym: "smooth muscle fiber development" EXACT [] +synonym: "smooth muscle fibre development" EXACT [] +is_obsolete: true + +[Term] +id: GO:0048749 +name: compound eye development +namespace: biological_process +alt_id: GO:0007456 +def: "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye] +synonym: "insect-type retina development" EXACT [PMID:11735386] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0048750 +name: compound eye corneal lens morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0001745 ! compound eye morphogenesis +relationship: part_of GO:0048058 ! compound eye corneal lens development + +[Term] +id: GO:0048752 +name: semicircular canal morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid] +synonym: "embryonic semicircular canal morphogenesis" EXACT [] +is_a: GO:0035239 ! tube morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0060872 ! semicircular canal development + +[Term] +id: GO:0048753 +name: pigment granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc] +subset: goslim_pir +synonym: "pigment granule organisation" EXACT [] +synonym: "pigment granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016050 ! vesicle organization +relationship: part_of GO:0033059 ! cellular pigmentation + +[Term] +id: GO:0048754 +name: branching morphogenesis of an epithelial tube +namespace: biological_process +def: "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid] +synonym: "tubulogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0035239 ! tube morphogenesis +is_a: GO:0061138 ! morphogenesis of a branching epithelium +relationship: part_of GO:0060562 ! epithelial tube morphogenesis + +[Term] +id: GO:0048755 +name: branching morphogenesis of a nerve +namespace: biological_process +def: "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid] +is_a: GO:0001763 ! morphogenesis of a branching structure +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0048756 +name: sieve cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [GOC:jid, PO:0025415, POC:curators] +is_a: GO:0090603 ! sieve element differentiation +relationship: part_of GO:0010088 ! phloem development + +[Term] +id: GO:0048757 +name: pigment granule maturation +namespace: biological_process +def: "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0043482 ! cellular pigment accumulation +relationship: part_of GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048758 +name: companion cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid] +is_a: GO:0048760 ! plant parenchymal cell differentiation +relationship: part_of GO:0010088 ! phloem development + +[Term] +id: GO:0048759 +name: xylem vessel member cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003] +synonym: "vessel element cell differentiation" BROAD [] +synonym: "vessel member cell differentiation" BROAD [] +is_a: GO:1905177 ! tracheary element differentiation +relationship: part_of GO:0010089 ! xylem development + +[Term] +id: GO:0048760 +name: plant parenchymal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421] +synonym: "parenchymal cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048761 +name: collenchyma cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048762 +name: mesenchymal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0060485 ! mesenchyme development + +[Term] +id: GO:0048763 +name: calcium-induced calcium release activity +namespace: molecular_function +def: "Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752] +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0048764 +name: trichoblast maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid] +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0010054 ! trichoblast differentiation + +[Term] +id: GO:0048765 +name: root hair cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid] +is_a: GO:0010053 ! root epidermal cell differentiation +is_a: GO:0048764 ! trichoblast maturation + +[Term] +id: GO:0048766 +name: root hair initiation +namespace: biological_process +def: "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0048765 ! root hair cell differentiation + +[Term] +id: GO:0048767 +name: root hair elongation +namespace: biological_process +def: "The process in which the root hair grows longer." [GOC:jid, PMID:12468740] +is_a: GO:0048588 ! developmental cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0080147 ! root hair cell development + +[Term] +id: GO:0048768 +name: root hair cell tip growth +namespace: biological_process +def: "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740] +synonym: "root hair tip growth" EXACT [] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0009932 ! cell tip growth +relationship: part_of GO:0048767 ! root hair elongation + +[Term] +id: GO:0048769 +name: sarcomerogenesis +namespace: biological_process +def: "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030] +synonym: "myofibril production" EXACT systematic_synonym [] +is_a: GO:0031032 ! actomyosin structure organization +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0048770 +name: pigment granule +namespace: cellular_component +def: "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0048771 +name: tissue remodeling +namespace: biological_process +def: "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0048772 +name: leucophore differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh] +synonym: "leucophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048773 +name: erythrophore differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh] +synonym: "erythrophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048774 +name: cyanophore differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh] +synonym: "cyanophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0048775 +name: regulation of leucophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leucophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048776 +name: negative regulation of leucophore differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh] +synonym: "down regulation of leucophore differentiation" EXACT [] +synonym: "down-regulation of leucophore differentiation" EXACT [] +synonym: "downregulation of leucophore differentiation" EXACT [] +synonym: "inhibition of leucophore differentiation" NARROW [] +is_a: GO:0048775 ! regulation of leucophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048777 +name: positive regulation of leucophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh] +synonym: "activation of leucophore differentiation" NARROW [] +synonym: "stimulation of leucophore differentiation" NARROW [] +synonym: "up regulation of leucophore differentiation" EXACT [] +synonym: "up-regulation of leucophore differentiation" EXACT [] +synonym: "upregulation of leucophore differentiation" EXACT [] +is_a: GO:0048775 ! regulation of leucophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048772 ! leucophore differentiation + +[Term] +id: GO:0048778 +name: regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048779 +name: negative regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +synonym: "down regulation of erythrophore differentiation" EXACT [] +synonym: "down-regulation of erythrophore differentiation" EXACT [] +synonym: "downregulation of erythrophore differentiation" EXACT [] +synonym: "inhibition of erythrophore differentiation" NARROW [] +is_a: GO:0048778 ! regulation of erythrophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048780 +name: positive regulation of erythrophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh] +synonym: "activation of erythrophore differentiation" NARROW [] +synonym: "stimulation of erythrophore differentiation" NARROW [] +synonym: "up regulation of erythrophore differentiation" EXACT [] +synonym: "up-regulation of erythrophore differentiation" EXACT [] +synonym: "upregulation of erythrophore differentiation" EXACT [] +is_a: GO:0048778 ! regulation of erythrophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048773 ! erythrophore differentiation + +[Term] +id: GO:0048781 +name: regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048782 +name: negative regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +synonym: "down regulation of cyanophore differentiation" EXACT [] +synonym: "down-regulation of cyanophore differentiation" EXACT [] +synonym: "downregulation of cyanophore differentiation" EXACT [] +synonym: "inhibition of cyanophore differentiation" NARROW [] +is_a: GO:0048781 ! regulation of cyanophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048783 +name: positive regulation of cyanophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh] +synonym: "activation of cyanophore differentiation" NARROW [] +synonym: "stimulation of cyanophore differentiation" NARROW [] +synonym: "up regulation of cyanophore differentiation" EXACT [] +synonym: "up-regulation of cyanophore differentiation" EXACT [] +synonym: "upregulation of cyanophore differentiation" EXACT [] +is_a: GO:0048781 ! regulation of cyanophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0048774 ! cyanophore differentiation + +[Term] +id: GO:0048784 +name: pigment biosynthetic process involved in pigment granule maturation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid] +synonym: "pigment biosynthetic process during pigment granule maturation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043324 ! pigment metabolic process involved in developmental pigmentation +is_a: GO:0043477 ! pigment biosynthetic process involved in pigment accumulation +relationship: part_of GO:0048757 ! pigment granule maturation + +[Term] +id: GO:0048785 +name: hatching gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0048786 +name: presynaptic active zone +namespace: cellular_component +def: "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289] +subset: goslim_synapse +synonym: "pre-synaptic active zone" EXACT [] +synonym: "pre-synaptic active zone component" NARROW [NIF_Subcellular:sao1911631652] +synonym: "presynaptic specialization" EXACT [] +xref: NIF_Subcellular:sao792027222 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0048787 +name: presynaptic active zone membrane +namespace: cellular_component +def: "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289] +subset: goslim_synapse +synonym: "active zone plasma membrane" EXACT [NIF_Subcellular:sao2038461087] +synonym: "active zone pre-synaptic plasma membrane" EXACT [] +synonym: "active zone presynaptic plasma membrane" EXACT [] +synonym: "pre-synaptic active zone membrane" EXACT [] +xref: NIF_Subcellular:sao2038461087 +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0042734 ! presynaptic membrane +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:0048788 +name: cytoskeleton of presynaptic active zone +namespace: cellular_component +def: "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438] +synonym: "active zone cytomatrix" EXACT [] +synonym: "CAZ" NARROW [] +synonym: "pre-synaptic cytoskeletal matrix assembled at active zones" EXACT [] +synonym: "pre-synaptic dense body" NARROW [NIF_Subcellular:sao1111202255, PMID:12575947] +synonym: "pre-synaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179] +synonym: "presynaptic cytomatrix assembled at active zones" EXACT [] +synonym: "presynaptic cytoskeletal matrix" EXACT syngo_official_label [] +synonym: "presynaptic cytoskeletal matrix assembled at active zones" EXACT [] +synonym: "presynaptic dense body" NARROW [PMID:16709774] +synonym: "presynaptic ribbon" RELATED [ISBN:0716723808, NIF_Subcellular:sao1488888179] +synonym: "ribbon" RELATED [NIF_Subcellular:sao1111202255, PMID:12575947] +synonym: "synaptic ribbon" NARROW [PMID:19264728] +synonym: "T-bar" NARROW [PMID:20127822] +synonym: "T-bar ribbon" NARROW [PMID:16384719] +xref: NIF_Subcellular:sao1470121605 +is_a: GO:0030863 ! cortical cytoskeleton +is_a: GO:0099569 ! presynaptic cytoskeleton +relationship: part_of GO:0098831 ! presynaptic active zone cytoplasmic component + +[Term] +id: GO:0048789 +name: cytoskeletal matrix organization at active zone +namespace: biological_process +def: "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759] +synonym: "cytoskeletal matrix organisation at active zone" EXACT [GOC:mah] +is_a: GO:0030865 ! cortical cytoskeleton organization + +[Term] +id: GO:0048790 +name: maintenance of presynaptic active zone structure +namespace: biological_process +def: "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr] +subset: goslim_synapse +synonym: "maintenance of pre-synaptic active zone structure" EXACT [] +is_a: GO:0099558 ! maintenance of synapse structure +is_a: GO:1990709 ! presynaptic active zone organization + +[Term] +id: GO:0048791 +name: calcium ion-regulated exocytosis of neurotransmitter +namespace: biological_process +def: "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels." [GOC:curators] +is_a: GO:0016079 ! synaptic vesicle exocytosis +is_a: GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:0048792 +name: spontaneous exocytosis of neurotransmitter +namespace: biological_process +def: "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators] +synonym: "spontaneous synaptic vesicle exocytosis" EXACT [] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0048793 +name: pronephros development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151] +synonym: "pronephric kidney development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0001822 ! kidney development + +[Term] +id: GO:0048794 +name: swim bladder development +namespace: biological_process +def: "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder development" EXACT [] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:0048795 +name: swim bladder morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder morphogenesis" EXACT [] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048794 ! swim bladder development + +[Term] +id: GO:0048796 +name: swim bladder maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol] +synonym: "gas bladder maturation" EXACT [] +is_a: GO:0048799 ! animal organ maturation +relationship: part_of GO:0048794 ! swim bladder development + +[Term] +id: GO:0048797 +name: swim bladder formation +namespace: biological_process +def: "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder biosynthesis" EXACT [] +synonym: "gas bladder formation" EXACT [] +is_a: GO:0048645 ! animal organ formation +relationship: part_of GO:0048795 ! swim bladder morphogenesis + +[Term] +id: GO:0048798 +name: swim bladder inflation +namespace: biological_process +def: "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh] +synonym: "gas bladder inflation" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048796 ! swim bladder maturation + +[Term] +id: GO:0048799 +name: animal organ maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0048800 +name: antennal morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0035107 ! appendage morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0007469 ! antennal development + +[Term] +id: GO:0048801 +name: antennal joint morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0048098 ! antennal joint development +relationship: part_of GO:0048800 ! antennal morphogenesis + +[Term] +id: GO:0048802 +name: notum morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007472 ! wing disc morphogenesis +relationship: part_of GO:0007477 ! notum development + +[Term] +id: GO:0048803 +name: imaginal disc-derived male genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] +synonym: "male genital morphogenesis" BROAD [] +is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis +is_a: GO:0048808 ! male genitalia morphogenesis +relationship: part_of GO:0007485 ! imaginal disc-derived male genitalia development + +[Term] +id: GO:0048804 +name: imaginal disc-derived female genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu] +synonym: "female genital morphogenesis" BROAD [] +is_a: GO:0048805 ! imaginal disc-derived genitalia morphogenesis +is_a: GO:0048807 ! female genitalia morphogenesis +relationship: part_of GO:0007486 ! imaginal disc-derived female genitalia development + +[Term] +id: GO:0048805 +name: imaginal disc-derived genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu] +synonym: "genital morphogenesis" BROAD [] +is_a: GO:0035126 ! post-embryonic genitalia morphogenesis +relationship: part_of GO:0007483 ! genital disc morphogenesis +relationship: part_of GO:0007484 ! imaginal disc-derived genitalia development + +[Term] +id: GO:0048806 +name: genitalia development +namespace: biological_process +def: "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid] +synonym: "genital development" EXACT [] +is_a: GO:0048513 ! animal organ development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0007548 ! sex differentiation + +[Term] +id: GO:0048807 +name: female genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah] +synonym: "female genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +relationship: part_of GO:0030540 ! female genitalia development + +[Term] +id: GO:0048808 +name: male genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888] +synonym: "male genital morphogenesis" RELATED [] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0090598 ! male anatomical structure morphogenesis +relationship: part_of GO:0030539 ! male genitalia development + +[Term] +id: GO:0048809 +name: analia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007483 ! genital disc morphogenesis +relationship: part_of GO:0007487 ! analia development + +[Term] +id: GO:0048810 +name: female analia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318] +is_a: GO:0048809 ! analia morphogenesis +relationship: part_of GO:0045497 ! female analia development + +[Term] +id: GO:0048811 +name: male analia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318] +is_a: GO:0048809 ! analia morphogenesis +relationship: part_of GO:0045496 ! male analia development + +[Term] +id: GO:0048812 +name: neuron projection morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah] +synonym: "neurite biosynthesis" NARROW [] +synonym: "neurite formation" NARROW [] +synonym: "neurite growth" NARROW [] +synonym: "neurite morphogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis +relationship: part_of GO:0031175 ! neuron projection development + +[Term] +id: GO:0048813 +name: dendrite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a dendrite are generated and organized." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] +is_a: GO:0048812 ! neuron projection morphogenesis +relationship: part_of GO:0016358 ! dendrite development +relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation + +[Term] +id: GO:0048814 +name: regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0050773 ! regulation of dendrite development +relationship: regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0048815 +name: hermaphrodite genitalia morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888] +is_a: GO:0035112 ! genitalia morphogenesis +is_a: GO:0035262 ! gonad morphogenesis +relationship: part_of GO:0040035 ! hermaphrodite genitalia development + +[Term] +id: GO:0048816 +name: ocellus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis +relationship: part_of GO:0008056 ! ocellus development + +[Term] +id: GO:0048817 +name: negative regulation of hair follicle maturation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +synonym: "down regulation of hair follicle maturation" EXACT [] +synonym: "down-regulation of hair follicle maturation" EXACT [] +synonym: "downregulation of hair follicle maturation" EXACT [] +synonym: "inhibition of hair follicle maturation" NARROW [] +is_a: GO:0048819 ! regulation of hair follicle maturation +is_a: GO:0051799 ! negative regulation of hair follicle development +relationship: negatively_regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048818 +name: positive regulation of hair follicle maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +synonym: "activation of hair follicle maturation" NARROW [] +synonym: "stimulation of hair follicle maturation" NARROW [] +synonym: "up regulation of hair follicle maturation" EXACT [] +synonym: "up-regulation of hair follicle maturation" EXACT [] +synonym: "upregulation of hair follicle maturation" EXACT [] +is_a: GO:0048819 ! regulation of hair follicle maturation +is_a: GO:0051798 ! positive regulation of hair follicle development +relationship: positively_regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048819 +name: regulation of hair follicle maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048820 ! hair follicle maturation + +[Term] +id: GO:0048820 +name: hair follicle maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol] +is_a: GO:0022405 ! hair cycle process +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0001942 ! hair follicle development + +[Term] +id: GO:0048821 +name: erythrocyte development +namespace: biological_process +def: "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol] +synonym: "RBC development" EXACT [CL:0000232] +synonym: "red blood cell development" EXACT [CL:0000232] +is_a: GO:0061515 ! myeloid cell development +relationship: part_of GO:0030218 ! erythrocyte differentiation + +[Term] +id: GO:0048822 +name: enucleate erythrocyte development +namespace: biological_process +def: "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] +synonym: "enucleate RBC development" EXACT [CL:0000232] +synonym: "enucleate red blood cell development" EXACT [CL:0000232] +is_a: GO:0048821 ! erythrocyte development +relationship: part_of GO:0043353 ! enucleate erythrocyte differentiation + +[Term] +id: GO:0048823 +name: nucleate erythrocyte development +namespace: biological_process +def: "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol] +synonym: "nucleate RBC development" EXACT [CL:0000232] +synonym: "nucleate red blood cell development" EXACT [CL:0000232] +is_a: GO:0048821 ! erythrocyte development +relationship: part_of GO:0043363 ! nucleate erythrocyte differentiation + +[Term] +id: GO:0048824 +name: pigment cell precursor differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899] +synonym: "chromatophore precursor differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048825 +name: cotyledon development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] +is_a: GO:0009793 ! embryo development ending in seed dormancy +is_a: GO:0048366 ! leaf development + +[Term] +id: GO:0048826 +name: cotyledon morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009965 ! leaf morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0090698 ! post-embryonic plant morphogenesis +relationship: part_of GO:0048825 ! cotyledon development + +[Term] +id: GO:0048827 +name: phyllome development +namespace: biological_process +def: "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001] +is_a: GO:0099402 ! plant organ development +relationship: part_of GO:0048367 ! shoot system development + +[Term] +id: GO:0048829 +name: root cap development +namespace: biological_process +def: "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0048830 +name: adventitious root development +namespace: biological_process +def: "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb] +is_a: GO:0048364 ! root development + +[Term] +id: GO:0048831 +name: regulation of shoot system development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392] +synonym: "regulation of shoot development" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048367 ! shoot system development + +[Term] +id: GO:0048832 +name: specification of plant organ number +namespace: biological_process +def: "The regionalization process that modulates the quantity of a particular type of plant organ." [GOC:dph, GOC:isa_complete, GOC:tb] +is_a: GO:0003002 ! regionalization +is_a: GO:0050793 ! regulation of developmental process + +[Term] +id: GO:0048833 +name: specification of floral organ number +namespace: biological_process +def: "Any process that modulates the number of floral organs formed in a floral whorl." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048832 ! specification of plant organ number +relationship: part_of GO:0009908 ! flower development + +[Term] +id: GO:0048834 +name: specification of petal number +namespace: biological_process +def: "Any process that modulates the number of petals formed in a flower." [GOC:tb] +is_a: GO:0048833 ! specification of floral organ number +relationship: part_of GO:0048465 ! corolla development + +[Term] +id: GO:0048835 +name: specification of decreased petal number +namespace: biological_process +def: "Any process that reduces the number of petals produced in a developing flower." [GOC:tb] +is_a: GO:0048834 ! specification of petal number + +[Term] +id: GO:0048836 +name: specification of increased petal number +namespace: biological_process +def: "Any process that increases the number of petals produced in a developing flower." [GOC:tb] +is_a: GO:0048834 ! specification of petal number + +[Term] +id: GO:0048837 +name: sorocarp sorus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp." [GOC:devbiol, GOC:mtg_sensu, PMID:4332228] +synonym: "sorocarp sorus formation" EXACT [] +synonym: "sorocarp spore head formation" EXACT [] +synonym: "sorocarp spore head morphogenesis" RELATED [] +is_a: GO:0099120 ! socially cooperative development +relationship: part_of GO:0031154 ! culmination involved in sorocarp development + +[Term] +id: GO:0048838 +name: release of seed from dormancy +namespace: biological_process +def: "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830] +is_a: GO:0010162 ! seed dormancy process +is_a: GO:0097438 ! exit from dormancy + +[Term] +id: GO:0048839 +name: inner ear development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043583 ! ear development + +[Term] +id: GO:0048840 +name: otolith development +namespace: biological_process +def: "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0048841 +name: regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +is_a: GO:0030516 ! regulation of axon extension +relationship: regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048842 +name: positive regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +synonym: "activation of axon extension involved in axon guidance" NARROW [] +synonym: "stimulation of axon extension involved in axon guidance" NARROW [] +synonym: "up regulation of axon extension involved in axon guidance" EXACT [] +synonym: "up-regulation of axon extension involved in axon guidance" EXACT [] +synonym: "upregulation of axon extension involved in axon guidance" EXACT [] +is_a: GO:0045773 ! positive regulation of axon extension +is_a: GO:0048841 ! regulation of axon extension involved in axon guidance +is_a: GO:0050921 ! positive regulation of chemotaxis +relationship: positively_regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048843 +name: negative regulation of axon extension involved in axon guidance +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol] +synonym: "down regulation of axon extension involved in axon guidance" EXACT [] +synonym: "down-regulation of axon extension involved in axon guidance" EXACT [] +synonym: "downregulation of axon extension involved in axon guidance" EXACT [] +synonym: "inhibition of axon extension involved in axon guidance" NARROW [] +is_a: GO:0030517 ! negative regulation of axon extension +is_a: GO:0048841 ! regulation of axon extension involved in axon guidance +is_a: GO:0050922 ! negative regulation of chemotaxis +relationship: negatively_regulates GO:0048846 ! axon extension involved in axon guidance + +[Term] +id: GO:0048844 +name: artery morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480] +synonym: "arterial morphogenesis" EXACT [] +synonym: "arteriogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0048514 ! blood vessel morphogenesis +relationship: part_of GO:0060840 ! artery development + +[Term] +id: GO:0048845 +name: venous blood vessel morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480] +synonym: "vein morphogenesis" BROAD [] +synonym: "venous morphogenesis" EXACT [] +is_a: GO:0048514 ! blood vessel morphogenesis +relationship: part_of GO:0060841 ! venous blood vessel development + +[Term] +id: GO:0048846 +name: axon extension involved in axon guidance +namespace: biological_process +def: "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid] +is_a: GO:0048675 ! axon extension +is_a: GO:1902284 ! neuron projection extension involved in neuron projection guidance +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:0048847 +name: adenohypophysis formation +namespace: biological_process +def: "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] +synonym: "adenophysis biosynthesis" EXACT [] +synonym: "adenophysis formation" EXACT [] +synonym: "anterior pituitary biosynthesis" EXACT [] +synonym: "anterior pituitary formation" EXACT [] +synonym: "anterior pituitary gland biosynthesis" EXACT [] +synonym: "anterior pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048855 ! adenohypophysis morphogenesis + +[Term] +id: GO:0048848 +name: neurohypophysis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neurophysis morphogenesis" EXACT [] +synonym: "posterior pituitary gland morphogenesis" EXACT [] +synonym: "posterior pituitary morphogenesis" EXACT [] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0021985 ! neurohypophysis development +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048849 +name: neurohypophysis formation +namespace: biological_process +def: "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "neurophysis biosynthesis" EXACT [] +synonym: "neurophysis formation" EXACT [] +synonym: "posterior pituitary biosynthesis" EXACT [] +synonym: "posterior pituitary formation" EXACT [] +synonym: "posterior pituitary gland biosynthesis" EXACT [] +synonym: "posterior pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048848 ! neurohypophysis morphogenesis + +[Term] +id: GO:0048850 +name: hypophysis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "pituitary gland morphogenesis" EXACT [] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0021983 ! pituitary gland development +relationship: part_of GO:0048852 ! diencephalon morphogenesis + +[Term] +id: GO:0048851 +name: hypophysis formation +namespace: biological_process +def: "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid] +synonym: "hypophysis biosynthesis" EXACT [] +synonym: "pituitary gland biosynthesis" EXACT [] +synonym: "pituitary gland formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048852 +name: diencephalon morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021536 ! diencephalon development +relationship: part_of GO:0048853 ! forebrain morphogenesis + +[Term] +id: GO:0048853 +name: forebrain morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] +synonym: "prosencephalon morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030900 ! forebrain development +relationship: part_of GO:0048854 ! brain morphogenesis + +[Term] +id: GO:0048854 +name: brain morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0007420 ! brain development + +[Term] +id: GO:0048855 +name: adenohypophysis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid] +synonym: "adenophysis morphogenesis" EXACT [] +synonym: "anterior pituitary gland morphogenesis" EXACT [] +synonym: "anterior pituitary morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021984 ! adenohypophysis development +relationship: part_of GO:0048850 ! hypophysis morphogenesis + +[Term] +id: GO:0048856 +name: anatomical structure development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_plant +synonym: "development of an anatomical structure" EXACT [] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0048857 +name: neural nucleus development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0048858 +name: cell projection morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021] +is_a: GO:0030030 ! cell projection organization +is_a: GO:0032990 ! cell part morphogenesis +relationship: part_of GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0048859 +name: formation of anatomical boundary +namespace: biological_process +def: "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0048860 +name: glioblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0048861 +name: leukemia inhibitory factor signaling pathway +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:devbiol, GOC:signaling] +synonym: "leukemia inhibitory factor signalling pathway" EXACT [] +is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway + +[Term] +id: GO:0048863 +name: stem cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete] +xref: Wikipedia:Stem_cell_differentiation +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0048864 +name: stem cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0048865 +name: stem cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0048866 +name: stem cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0048865 ! stem cell fate commitment + +[Term] +id: GO:0048867 +name: stem cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0048865 ! stem cell fate commitment + +[Term] +id: GO:0048868 +name: pollen tube development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009856 ! pollination + +[Term] +id: GO:0048869 +name: cellular developmental process +namespace: biological_process +def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] +is_a: GO:0009987 ! cellular process +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0048870 +name: cell motility +namespace: biological_process +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +synonym: "cell locomotion" EXACT [] +synonym: "cell movement" RELATED [] +synonym: "movement of a cell" EXACT [] +is_a: GO:0006928 ! movement of cell or subcellular component +is_a: GO:0040011 ! locomotion +relationship: part_of GO:0051674 ! localization of cell + +[Term] +id: GO:0048871 +name: multicellular organismal homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048872 +name: homeostasis of number of cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] +synonym: "cell population homeostasis" EXACT [] +synonym: "homeostasis of cell number" EXACT [GOC:dph] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048873 +name: homeostasis of number of cells within a tissue +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete] +is_a: GO:0001894 ! tissue homeostasis +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0048874 +name: host-mediated regulation of intestinal microbiota composition +namespace: biological_process +def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [PMID:25757720] +synonym: "homeostasis of number of cells in a free-living population" RELATED [] +synonym: "host-induced regulation of intestinal microbiota composition" RELATED [] +is_a: GO:0048872 ! homeostasis of number of cells +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0048875 +name: chemical homeostasis within a tissue +namespace: biological_process +def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete] +is_a: GO:0001894 ! tissue homeostasis +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0048876 +name: chemical homeostasis within retina +namespace: biological_process +def: "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete] +is_a: GO:0001895 ! retina homeostasis +is_a: GO:0048875 ! chemical homeostasis within a tissue + +[Term] +id: GO:0048877 +name: homeostasis of number of retina cells +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb] +is_a: GO:0001895 ! retina homeostasis +is_a: GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0048878 +name: chemical homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] +subset: goslim_drosophila +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0048880 +name: sensory system development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0048881 +name: mechanosensory lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509] +synonym: "LL system development" EXACT [ISBN:0125296509] +is_a: GO:0048925 ! lateral line system development + +[Term] +id: GO:0048882 +name: lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509] +synonym: "LL development" EXACT [] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048883 +name: neuromast primordium migration +namespace: biological_process +def: "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385] +synonym: "lateral line primordium migration" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0048882 ! lateral line development + +[Term] +id: GO:0048884 +name: neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0048882 ! lateral line development + +[Term] +id: GO:0048885 +name: neuromast deposition +namespace: biological_process +def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940] +is_a: GO:0030336 ! negative regulation of cell migration +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048886 +name: neuromast hair cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509] +is_a: GO:0035315 ! hair cell differentiation +is_a: GO:0042490 ! mechanoreceptor differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048887 +name: cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048888 +name: neuromast mantle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048889 +name: neuromast support cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048884 ! neuromast development + +[Term] +id: GO:0048890 +name: lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377] +synonym: "gLL ganglion development" EXACT [] +is_a: GO:0061550 ! cranial ganglion development +relationship: part_of GO:0007422 ! peripheral nervous system development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048891 +name: lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940] +synonym: "gLL neuron differentiation" EXACT [] +is_a: GO:0048934 ! peripheral nervous system neuron differentiation +relationship: part_of GO:0048890 ! lateral line ganglion development + +[Term] +id: GO:0048892 +name: lateral line nerve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509] +synonym: "nLL development" EXACT [] +is_a: GO:0021545 ! cranial nerve development +relationship: part_of GO:0048925 ! lateral line system development + +[Term] +id: GO:0048893 +name: afferent axon development in lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385] +is_a: GO:0061564 ! axon development +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048894 +name: efferent axon development in a lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385] +is_a: GO:0021955 ! central nervous system neuron axonogenesis +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048895 +name: lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041] +is_a: GO:0010001 ! glial cell differentiation +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048896 +name: lateral line nerve glial cell migration +namespace: biological_process +def: "The movement of a glial cell along the axons in a lateral line nerve." [PMID:12062041] +synonym: "glial cell migration in lateral line nerve" EXACT [] +is_a: GO:0036135 ! Schwann cell migration +relationship: part_of GO:0048892 ! lateral line nerve development + +[Term] +id: GO:0048897 +name: myelination of lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of a lateral line nerve." [PMID:12112375] +is_a: GO:0042552 ! myelination +relationship: part_of GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048898 +name: anterior lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] +synonym: "ALL system development" RELATED [] +is_a: GO:0048925 ! lateral line system development +relationship: part_of GO:0048881 ! mechanosensory lateral line system development + +[Term] +id: GO:0048899 +name: anterior lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] +synonym: "anterior LL development" EXACT [] +is_a: GO:0048882 ! lateral line development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048900 +name: anterior lateral line neuromast primordium migration +namespace: biological_process +def: "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] +synonym: "ALL neuromast primordium migration" EXACT [] +is_a: GO:0048883 ! neuromast primordium migration +relationship: part_of GO:0048899 ! anterior lateral line development + +[Term] +id: GO:0048901 +name: anterior lateral line neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0048884 ! neuromast development +relationship: part_of GO:0048899 ! anterior lateral line development + +[Term] +id: GO:0048902 +name: anterior lateral line neuromast deposition +namespace: biological_process +def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385] +is_a: GO:0048885 ! neuromast deposition +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048903 +name: anterior lateral line neuromast hair cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377] +is_a: GO:0048886 ! neuromast hair cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048904 +name: anterior lateral line neuromast cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048887 ! cupula development +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048905 +name: anterior lateral line neuromast mantle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0048888 ! neuromast mantle cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048906 +name: anterior lateral line neuromast support cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] +is_a: GO:0048889 ! neuromast support cell differentiation +relationship: part_of GO:0048901 ! anterior lateral line neuromast development + +[Term] +id: GO:0048907 +name: anterior lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509] +synonym: "gALL development" EXACT [] +is_a: GO:0048890 ! lateral line ganglion development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048908 +name: anterior lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940] +is_a: GO:0048891 ! lateral line ganglion neuron differentiation +relationship: part_of GO:0048907 ! anterior lateral line ganglion development + +[Term] +id: GO:0048909 +name: anterior lateral line nerve development +namespace: biological_process +alt_id: GO:0021734 +def: "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509] +synonym: "ALLN development" EXACT [] +synonym: "nALL development" EXACT [] +synonym: "rostral lateral line nerve development" EXACT [] +is_a: GO:0048892 ! lateral line nerve development +relationship: part_of GO:0048898 ! anterior lateral line system development + +[Term] +id: GO:0048910 +name: afferent axon development in anterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940] +is_a: GO:0048893 ! afferent axon development in lateral line nerve +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048911 +name: efferent axon development in anterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940] +is_a: GO:0048894 ! efferent axon development in a lateral line nerve +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048912 +name: glial cell migration in anterior lateral line nerve +namespace: biological_process +def: "The movement of a glial cell along the axons in the anterior lateral line nerve." [PMID:12062041] +is_a: GO:0048896 ! lateral line nerve glial cell migration +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048913 +name: anterior lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385] +is_a: GO:0048895 ! lateral line nerve glial cell differentiation +relationship: part_of GO:0048909 ! anterior lateral line nerve development + +[Term] +id: GO:0048914 +name: myelination of anterior lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375] +is_a: GO:0048897 ! myelination of lateral line nerve axons +relationship: part_of GO:0048940 ! anterior lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048915 +name: posterior lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940] +synonym: "PLL" RELATED [] +is_a: GO:0048925 ! lateral line system development +relationship: part_of GO:0048881 ! mechanosensory lateral line system development + +[Term] +id: GO:0048916 +name: posterior lateral line development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509] +synonym: "PLL development" EXACT [] +is_a: GO:0048882 ! lateral line development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048917 +name: posterior lateral line ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377] +synonym: "gPLL development" EXACT [] +is_a: GO:0048890 ! lateral line ganglion development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048918 +name: posterior lateral line nerve development +namespace: biological_process +alt_id: GO:0021733 +def: "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0125296509] +synonym: "caudal lateral line nerve development" EXACT [] +synonym: "PLLN development" EXACT [] +is_a: GO:0048892 ! lateral line nerve development +relationship: part_of GO:0048915 ! posterior lateral line system development + +[Term] +id: GO:0048919 +name: posterior lateral line neuromast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509] +is_a: GO:0048884 ! neuromast development +relationship: part_of GO:0048916 ! posterior lateral line development + +[Term] +id: GO:0048920 +name: posterior lateral line neuromast primordium migration +namespace: biological_process +def: "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385] +synonym: "PLL neuromast primordium migration" EXACT [] +is_a: GO:0048883 ! neuromast primordium migration +relationship: part_of GO:0048916 ! posterior lateral line development + +[Term] +id: GO:0048921 +name: posterior lateral line neuromast cupula development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509] +is_a: GO:0048887 ! cupula development +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048922 +name: posterior lateral line neuromast deposition +namespace: biological_process +def: "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385] +is_a: GO:0048885 ! neuromast deposition +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048923 +name: posterior lateral line neuromast hair cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509] +is_a: GO:0048886 ! neuromast hair cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048924 +name: posterior lateral line neuromast mantle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509] +is_a: GO:0048888 ! neuromast mantle cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048925 +name: lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509] +is_a: GO:0048880 ! sensory system development + +[Term] +id: GO:0048926 +name: electrosensory lateral line system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh] +is_a: GO:0048925 ! lateral line system development + +[Term] +id: GO:0048927 +name: posterior lateral line neuromast support cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377] +is_a: GO:0048889 ! neuromast support cell differentiation +relationship: part_of GO:0048919 ! posterior lateral line neuromast development + +[Term] +id: GO:0048928 +name: posterior lateral line ganglion neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940] +is_a: GO:0048891 ! lateral line ganglion neuron differentiation +relationship: part_of GO:0048917 ! posterior lateral line ganglion development + +[Term] +id: GO:0048929 +name: efferent axon development in posterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940] +is_a: GO:0048894 ! efferent axon development in a lateral line nerve +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048930 +name: glial cell migration in posterior lateral line nerve +namespace: biological_process +def: "The movement of a glial cell along the axons in the posterior lateral line nerve." [PMID:12062041] +is_a: GO:0048896 ! lateral line nerve glial cell migration +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048931 +name: posterior lateral line nerve glial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385] +is_a: GO:0048895 ! lateral line nerve glial cell differentiation +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048932 +name: myelination of posterior lateral line nerve axons +namespace: biological_process +def: "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375] +is_a: GO:0048897 ! myelination of lateral line nerve axons +relationship: part_of GO:0048942 ! posterior lateral line nerve glial cell morphogenesis involved in differentiation + +[Term] +id: GO:0048933 +name: afferent axon development in posterior lateral line nerve +namespace: biological_process +def: "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940] +is_a: GO:0048893 ! afferent axon development in lateral line nerve +relationship: part_of GO:0048918 ! posterior lateral line nerve development + +[Term] +id: GO:0048934 +name: peripheral nervous system neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0007422 ! peripheral nervous system development + +[Term] +id: GO:0048935 +name: peripheral nervous system neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0048934 ! peripheral nervous system neuron differentiation + +[Term] +id: GO:0048936 +name: peripheral nervous system neuron axonogenesis +namespace: biological_process +def: "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh] +is_a: GO:0007409 ! axonogenesis +relationship: part_of GO:0048935 ! peripheral nervous system neuron development + +[Term] +id: GO:0048937 +name: lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0021782 ! glial cell development +relationship: part_of GO:0048895 ! lateral line nerve glial cell differentiation + +[Term] +id: GO:0048938 +name: lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0048937 ! lateral line nerve glial cell development + +[Term] +id: GO:0048939 +name: anterior lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0048937 ! lateral line nerve glial cell development +relationship: part_of GO:0048913 ! anterior lateral line nerve glial cell differentiation + +[Term] +id: GO:0048940 +name: anterior lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] +is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation +relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development + +[Term] +id: GO:0048941 +name: posterior lateral line nerve glial cell development +namespace: biological_process +def: "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh] +is_a: GO:0048937 ! lateral line nerve glial cell development +relationship: part_of GO:0048931 ! posterior lateral line nerve glial cell differentiation + +[Term] +id: GO:0048942 +name: posterior lateral line nerve glial cell morphogenesis involved in differentiation +namespace: biological_process +def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] +is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation +relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development + +[Term] +id: GO:0050000 +name: chromosome localization +namespace: biological_process +def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] +synonym: "chromosome localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of chromosome localization" EXACT [] +synonym: "establishment and maintenance of chromosome position" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0050001 +name: D-glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN] +synonym: "D-glutamine amidohydrolase activity" RELATED [EC:3.5.1.35] +xref: EC:3.5.1.35 +xref: MetaCyc:D-GLUTAMINASE-RXN +xref: RHEA:22840 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050002 +name: D-proline reductase (dithiol) activity +namespace: molecular_function +def: "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN] +comment: Note that this function was formerly EC:1.4.4.1. +synonym: "5-aminopentanoate:lipoate oxidoreductase (cyclizing)" RELATED [EC:1.21.4.1] +xref: EC:1.21.4.1 +xref: MetaCyc:1.21.4.1-RXN +xref: RHEA:12737 +is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor + +[Term] +id: GO:0050003 +name: deoxycytidylate C-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11568] +synonym: "5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity" RELATED [EC:2.1.1.54] +synonym: "dCMP methyltransferase activity" RELATED [EC:2.1.1.54] +synonym: "deoxycytidylate methyltransferase activity" RELATED [EC:2.1.1.54] +xref: EC:2.1.1.54 +xref: KEGG_REACTION:R01670 +xref: MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN +xref: RHEA:11568 +is_a: GO:0008169 ! C-methyltransferase activity + +[Term] +id: GO:0050004 +name: isoflavone 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.170] +synonym: "UDPglucose-flavonoid 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170] +synonym: "UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.170] +synonym: "UDPglucose:isoflavone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170] +synonym: "uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity" RELATED [EC:2.4.1.170] +xref: EC:2.4.1.170 +xref: MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:56344 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050005 +name: isohexenylglutaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O." [EC:4.2.1.57, RHEA:24144] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]" RELATED [EC:4.2.1.57] +synonym: "3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity" RELATED [EC:4.2.1.57] +synonym: "3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity" RELATED [EC:4.2.1.57] +synonym: "beta-isohexenylglutaconyl-CoA-hydratase activity" RELATED [EC:4.2.1.57] +synonym: "isohexenylglutaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.57] +xref: EC:4.2.1.57 +xref: KEGG_REACTION:R03493 +xref: MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN +xref: RHEA:24144 +xref: UM-BBD_reactionID:r1167 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050006 +name: isomaltulose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN] +synonym: "isomaltulose synthetase activity" RELATED [EC:5.4.99.11] +synonym: "sucrose alpha-glucosyltransferase activity" RELATED [EC:5.4.99.11] +synonym: "sucrose glucosylmutase activity" RELATED [EC:5.4.99.11] +synonym: "trehalulose synthase activity" RELATED [EC:5.4.99.11] +xref: EC:5.4.99.11 +xref: MetaCyc:ISOMALTULOSE-SYNTHASE-RXN +xref: RHEA:24032 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050007 +name: isonocardicin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A." [EC:2.5.1.38, RHEA:19845] +synonym: "nocardicin aminocarboxypropyltransferase activity" RELATED [EC:2.5.1.38] +synonym: "S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity" RELATED [EC:2.5.1.38] +xref: EC:2.5.1.38 +xref: KEGG_REACTION:R03072 +xref: MetaCyc:ISONOCARDICIN-SYNTHASE-RXN +xref: RHEA:19845 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050008 +name: isopiperitenone delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopiperitenone = piperitenone." [EC:5.3.3.11, RHEA:21516] +synonym: "isopiperitenone D-isomerase activity" EXACT [] +synonym: "isopiperitenone delta8-delta4-isomerase activity" RELATED [EC:5.3.3.11] +xref: EC:5.3.3.11 +xref: KEGG_REACTION:R03782 +xref: MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN +xref: RHEA:21516 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050009 +name: isopropanol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH." [EC:1.1.1.80, RHEA:21792] +synonym: "propan-2-ol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.80] +xref: EC:1.1.1.80 +xref: KEGG_REACTION:R01550 +xref: MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN +xref: RHEA:21792 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050010 +name: isovitexin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19529] +synonym: "isovitexin b-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.106] +synonym: "UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.106] +synonym: "uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity" RELATED [EC:2.4.1.106] +xref: EC:2.4.1.106 +xref: KEGG_REACTION:R03686 +xref: MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:19529 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050011 +name: itaconyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN] +synonym: "citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)" RELATED [EC:4.2.1.56] +synonym: "citramalyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.56] +synonym: "itaconyl coenzyme A hydratase activity" RELATED [EC:4.2.1.56] +xref: EC:4.2.1.56 +xref: MetaCyc:ITACONYL-COA-HYDRATASE-RXN +xref: RHEA:13785 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050012 +name: juglone 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+." [PMID:4041238, RHEA:18745] +comment: Formerly EC:1.14.99.27. +synonym: "5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)" RELATED [] +synonym: "juglone 3-monooxygenase activity" EXACT [] +synonym: "juglone hydroxylase activity" EXACT [] +synonym: "naphthoquinone hydroxylase activity" RELATED [EC:1.17.3.4] +xref: EC:1.17.3.4 +xref: KEGG_REACTION:R04327 +xref: MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN +xref: RHEA:18745 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0050013 +name: 2-dehydropantoate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN] +synonym: "2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming)" RELATED [EC:4.1.2.12] +synonym: "2-dehydropantoate formaldehyde-lyase activity" RELATED [EC:4.1.2.12] +synonym: "ketopantoaldolase activity" EXACT [] +xref: EC:4.1.2.12 +xref: MetaCyc:KETOPANTOALDOLASE-RXN +xref: RHEA:23276 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050014 +name: ketotetrose-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20932] +synonym: "erythrose-1-phosphate synthase activity" RELATED [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)" RELATED [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate formaldehyde-lyase activity" RELATED [EC:4.1.2.2] +synonym: "erythrulose-1-phosphate synthetase activity" RELATED [EC:4.1.2.2] +synonym: "phosphoketotetrose aldolase activity" RELATED [EC:4.1.2.2] +xref: EC:4.1.2.2 +xref: KEGG_REACTION:R01014 +xref: MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN +xref: RHEA:20932 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050015 +name: kievitone hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone." [EC:4.2.1.95, RHEA:23604] +synonym: "KHase activity" RELATED [EC:4.2.1.95] +synonym: "kievitone-hydrate hydro-lyase (kievitone-forming)" RELATED [EC:4.2.1.95] +synonym: "kievitone-hydrate hydro-lyase activity" RELATED [EC:4.2.1.95] +xref: EC:4.2.1.95 +xref: KEGG_REACTION:R03622 +xref: MetaCyc:KIEVITONE-HYDRATASE-RXN +xref: RHEA:23604 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050016 +name: kynurenine 7,8-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN] +synonym: "kynurenate 7,8-hydroxylase activity" RELATED [EC:1.14.99.2] +synonym: "kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.99.2] +synonym: "kynurenic acid hydroxylase activity" RELATED [EC:1.14.99.2] +synonym: "kynurenic hydroxylase activity" RELATED [EC:1.14.99.2] +xref: EC:1.14.99.2 +xref: MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN +xref: RHEA:11968 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050017 +name: L-3-cyanoalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN] +synonym: "beta-cyano-L-alanine synthase activity" RELATED [EC:4.4.1.9] +synonym: "beta-cyanoalanine synthase activity" RELATED [EC:4.4.1.9] +synonym: "beta-cyanoalanine synthetase activity" RELATED [EC:4.4.1.9] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding HCN)" RELATED [EC:4.4.1.9] +synonym: "L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)" RELATED [EC:4.4.1.9] +xref: EC:4.4.1.9 +xref: MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN +xref: RHEA:17821 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050018 +name: L-amino-acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN] +synonym: "L-amino-acid:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.5] +xref: EC:1.4.1.5 +xref: MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN +xref: RHEA:10396 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050019 +name: L-arabinitol 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH." [EC:1.1.1.12, RHEA:16381] +xref: EC:1.1.1.12 +xref: KEGG_REACTION:R01903 +xref: MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN +xref: RHEA:16381 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050020 +name: L-arabinonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O." [EC:4.2.1.25, RHEA:20968] +synonym: "L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming)" RELATED [EC:4.2.1.25] +synonym: "L-arabinonate hydro-lyase activity" RELATED [EC:4.2.1.25] +synonym: "L-arabonate dehydrase activity" RELATED [EC:4.2.1.25] +synonym: "L-arabonate dehydratase activity" RELATED [EC:4.2.1.25] +xref: EC:4.2.1.25 +xref: KEGG_REACTION:R02522 +xref: MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN +xref: RHEA:20968 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050021 +name: L-arabinonolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+)." [EC:3.1.1.15, RHEA:16217] +synonym: "L-arabinono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.15] +xref: EC:3.1.1.15 +xref: KEGG_REACTION:R02526 +xref: MetaCyc:L-ARABINONOLACTONASE-RXN +xref: RHEA:16217 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050022 +name: L-arabinose 1-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN] +synonym: "L-arabinose 1-dehydrogenase activity" BROAD [] +synonym: "L-arabinose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.46] +xref: EC:1.1.1.46 +xref: MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN +xref: RHEA:17925 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050023 +name: L-fuconate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O." [EC:4.2.1.68, RHEA:22772] +synonym: "L-fuconate hydratase activity" EXACT [] +synonym: "L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)" RELATED [EC:4.2.1.68] +synonym: "L-fuconate hydro-lyase activity" RELATED [EC:4.2.1.68] +xref: EC:4.2.1.68 +xref: KEGG_REACTION:R03688 +xref: MetaCyc:L-FUCONATE-HYDRATASE-RXN +xref: RHEA:22772 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050024 +name: L-galactonolactone oxidase activity +namespace: molecular_function +alt_id: GO:0033733 +def: "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+)." [EC:1.3.3.12, RHEA:20617] +synonym: "L-galactono-1,4-lactone oxidase activity" RELATED [EC:1.3.3.12] +synonym: "L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity" RELATED [EC:1.3.3.12] +synonym: "L-xylono-1,4-lactone oxidase activity" RELATED [EC:1.3.3.12] +xref: EC:1.3.3.12 +xref: KEGG_REACTION:R00643 +xref: MetaCyc:1.3.3.12-RXN +xref: RHEA:20617 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050025 +name: L-glutamate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN] +synonym: "glutamate (acceptor) dehydrogenase activity" RELATED [EC:1.4.3.11] +synonym: "glutamate oxidase activity" RELATED [EC:1.4.3.11] +synonym: "glutamic acid oxidase activity" RELATED [EC:1.4.3.11] +synonym: "glutamic dehydrogenase (acceptor)" RELATED [EC:1.4.3.11] +synonym: "L-glutamate:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.11] +synonym: "L-glutamic acid oxidase activity" RELATED [EC:1.4.3.11] +xref: EC:1.4.3.11 +xref: MetaCyc:L-GLUTAMATE-OXIDASE-RXN +xref: RHEA:20728 +is_a: GO:0001716 ! L-amino-acid oxidase activity + +[Term] +id: GO:0050026 +name: L-glycol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN] +synonym: "glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity" RELATED [EC:1.1.1.185] +synonym: "L-(+)-glycol:NAD(P) oxidoreductase activity" RELATED [EC:1.1.1.185] +synonym: "L-glycol:NAD(P) dehydrogenase activity" RELATED [EC:1.1.1.185] +synonym: "L-glycol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.185] +xref: EC:1.1.1.185 +xref: MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050027 +name: obsolete L-idonate 2-dehydrogenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN] +comment: This term was made obsolete because EC:1.1.1.128 was deleted: the reaction described is covered by EC:1.1.1.264. +synonym: "5-keto-D-gluconate 2-reductase activity" RELATED [EC:1.1.1.128] +synonym: "5-ketogluconate 2-reductase activity" RELATED [EC:1.1.1.128] +synonym: "5-ketoglucono-idono-reductase activity" RELATED [EC:1.1.1.128] +synonym: "5KGR" RELATED [EC:1.1.1.128] +synonym: "L-idonate 2-dehydrogenase activity" EXACT [] +synonym: "L-idonate dehydrogenase activity" RELATED [EC:1.1.1.128] +synonym: "L-idonate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.128] +synonym: "reductase, 5-ketogluconate 5- (L-idonate-forming)" RELATED [EC:1.1.1.128] +xref: EC:1.1.1.128 +xref: MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN +xref: RHEA:21176 +is_obsolete: true +consider: GO:0050572 + +[Term] +id: GO:0050028 +name: L-lysine-lactamase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine." [EC:3.5.2.11, RHEA:21388] +synonym: "L-alpha-aminocaprolactam hydrolase activity" RELATED [EC:3.5.2.11] +synonym: "L-lysinamidase activity" RELATED [EC:3.5.2.11] +synonym: "L-lysine-1,6-lactam lactamhydrolase activity" RELATED [EC:3.5.2.11] +xref: EC:3.5.2.11 +xref: KEGG_REACTION:R00463 +xref: MetaCyc:L-LYSINE-LACTAMASE-RXN +xref: RHEA:21388 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050029 +name: L-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+)." [EC:1.4.3.14, RHEA:14437] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "L-lysine alpha-oxidase activity" RELATED [EC:1.4.3.14] +synonym: "L-lysine:oxygen 2-oxidoreductase (deaminating)" RELATED [EC:1.4.3.14] +synonym: "L-lysyl-alpha-oxidase activity" RELATED [EC:1.4.3.14] +xref: EC:1.4.3.14 +xref: KEGG_REACTION:R00447 +xref: MetaCyc:L-LYSINE-OXIDASE-RXN +xref: MetaCyc:PWY-5311 +xref: RHEA:14437 +is_a: GO:0001716 ! L-amino-acid oxidase activity + +[Term] +id: GO:0050030 +name: L-pipecolate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN] +synonym: "L-pipecolate:(acceptor) 1,6-oxidoreductase activity" RELATED [EC:1.5.99.3] +synonym: "L-pipecolate:acceptor 1,6-oxidoreductase activity" RELATED [EC:1.5.99.3] +xref: EC:1.5.99.3 +xref: MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN +xref: RHEA:19777 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050031 +name: L-pipecolate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11992] +synonym: "L-pipecolate:oxygen 1,6-oxidoreductase activity" RELATED [EC:1.5.3.7] +synonym: "L-pipecolic acid oxidase activity" RELATED [EC:1.5.3.7] +xref: EC:1.5.3.7 +xref: KEGG_REACTION:R02204 +xref: MetaCyc:L-PIPECOLATE-OXIDASE-RXN +xref: Reactome:R-HSA-6783880 "PIPOX oxidises PPCA to P6C" +xref: RHEA:11992 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050032 +name: L-rhamnonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O." [EC:4.2.1.90, RHEA:23080] +synonym: "L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming)" RELATED [EC:4.2.1.90] +synonym: "L-rhamnonate hydro-lyase activity" RELATED [EC:4.2.1.90] +xref: EC:4.2.1.90 +xref: KEGG_REACTION:R03774 +xref: MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN +xref: RHEA:23080 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050033 +name: L-rhamnono-1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+)." [EC:3.1.1.65, RHEA:10288] +synonym: "L-rhamno-gamma-lactonase activity" RELATED [EC:3.1.1.65] +synonym: "L-rhamnono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.65] +synonym: "L-rhamnono-gamma-lactonase activity" RELATED [EC:3.1.1.65] +xref: EC:3.1.1.65 +xref: KEGG_REACTION:R03772 +xref: MetaCyc:L-RHAMNONO-14-LACTONASE-RXN +xref: RHEA:10288 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050034 +name: L-rhamnose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH." [EC:1.1.1.173, RHEA:12649] +synonym: "L-rhamnofuranose:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.173] +xref: EC:1.1.1.173 +xref: KEGG_REACTION:R03942 +xref: MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN +xref: RHEA:12649 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050035 +name: L-sorbose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2)." [EC:1.1.3.11, RHEA:17853] +synonym: "L-sorbose:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.11] +xref: EC:1.1.3.11 +xref: KEGG_REACTION:R01695 +xref: MetaCyc:L-SORBOSE-OXIDASE-RXN +xref: RHEA:17853 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050036 +name: L-threonate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH." [EC:1.1.1.129, RHEA:23376] +synonym: "L-threonate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.129] +synonym: "L-threonic acid dehydrogenase activity" RELATED [EC:1.1.1.129] +synonym: "threonate dehydrogenase activity" RELATED [EC:1.1.1.129] +xref: EC:1.1.1.129 +xref: KEGG_REACTION:R03733 +xref: MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN +xref: RHEA:23376 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050037 +name: L-xylose 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH." [EC:1.1.1.113, RHEA:15789] +synonym: "L-xylose dehydrogenase activity" RELATED [EC:1.1.1.113] +synonym: "L-xylose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.113] +synonym: "NADPH-xylose reductase activity" RELATED [EC:1.1.1.113] +xref: EC:1.1.1.113 +xref: KEGG_REACTION:R03586 +xref: MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN +xref: RHEA:15789 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050038 +name: L-xylulose reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17025] +synonym: "L-xylulose reductase activity" BROAD [] +xref: EC:1.1.1.10 +xref: KEGG_REACTION:R01904 +xref: MetaCyc:L-XYLULOSE-REDUCTASE-RXN +xref: Reactome:R-HSA-5661240 "DCXR tetramer reduces L-xylulose to xylitol" +xref: Reactome:R-HSA-5662851 "Defective DCXR does not reduce L-xylulose to xylitol" +xref: RHEA:17025 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050039 +name: lactaldehyde reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH." [EC:1.1.1.55, RHEA:15885] +synonym: "1,2-propanediol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.55] +synonym: "lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.1.1.55] +synonym: "NADP-1,2-propanediol dehydrogenase activity" RELATED [EC:1.1.1.55] +synonym: "propane-1,2-diol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.55] +synonym: "propanediol dehydrogenase activity" RELATED [EC:1.1.1.55] +xref: EC:1.1.1.55 +xref: KEGG_REACTION:R02259 +xref: MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN +xref: RHEA:15885 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050040 +name: lactate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O." [EC:1.13.12.4, RHEA:16513] +synonym: "(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.4] +synonym: "L-lactate monooxygenase activity" RELATED [EC:1.13.12.4] +synonym: "L-lactate-2-monooxygenase activity" RELATED [EC:1.13.12.4] +synonym: "lactate monooxygenase activity" RELATED [EC:1.13.12.4] +synonym: "lactate oxidase activity" RELATED [EC:1.13.12.4] +synonym: "lactate oxidative decarboxylase activity" RELATED [EC:1.13.12.4] +synonym: "lactate oxygenase activity" RELATED [EC:1.13.12.4] +synonym: "lactic oxidase activity" RELATED [EC:1.13.12.4] +synonym: "lactic oxygenase activity" RELATED [EC:1.13.12.4] +xref: EC:1.13.12.4 +xref: KEGG_REACTION:R00319 +xref: MetaCyc:LACTATE-2-MONOOXYGENASE-RXN +xref: RHEA:16513 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050041 +name: lactate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate = acetaldehyde + formate." [EC:4.1.2.36, RHEA:17909] +synonym: "(S)-lactate acetaldehyde-lyase (formate-forming)" RELATED [EC:4.1.2.36] +synonym: "(S)-lactate acetaldehyde-lyase activity" RELATED [EC:4.1.2.36] +synonym: "lactate synthase activity" RELATED [EC:4.1.2.36] +xref: EC:4.1.2.36 +xref: KEGG_REACTION:R00753 +xref: MetaCyc:LACTATE-ALDOLASE-RXN +xref: RHEA:17909 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050042 +name: lactate-malate transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10984] +synonym: "(S)-lactate:oxaloacetate oxidoreductase activity" RELATED [EC:1.1.99.7] +synonym: "malate-lactate transhydrogenase activity" RELATED [EC:1.1.99.7] +xref: EC:1.1.99.7 +xref: KEGG_REACTION:R01447 +xref: MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN +xref: RHEA:10984 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050043 +name: lactate racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-lactate = (R)-lactate." [EC:5.1.2.1, RHEA:10960] +synonym: "hydroxyacid racemase activity" RELATED [EC:5.1.2.1] +synonym: "lactic acid racemase activity" RELATED [EC:5.1.2.1] +synonym: "lacticoracemase activity" RELATED [EC:5.1.2.1] +xref: EC:5.1.2.1 +xref: KEGG_REACTION:R01450 +xref: MetaCyc:LACTATE-RACEMASE-RXN +xref: RHEA:10960 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0050044 +name: galactose-6-phosphate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13033] +synonym: "D-galactose-6-phosphate aldose-ketose-isomerase activity" RELATED [EC:5.3.1.26] +synonym: "D-galactose-6-phosphate ketol-isomerase activity" RELATED [EC:5.3.1.26] +xref: EC:5.3.1.26 +xref: KEGG_REACTION:R03240 +xref: MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN +xref: RHEA:13033 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050045 +name: laminaribiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN] +synonym: "3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.31] +xref: EC:2.4.1.31 +xref: MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN +xref: RHEA:16617 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050046 +name: delta7-sterol 5(6)-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O." [RHEA:46556] +synonym: "5-DES" RELATED [EC:1.14.19.20] +synonym: "delta7-sterol 5-desaturase activity" RELATED [EC:1.14.19.20] +synonym: "delta7-sterol delta5-dehydrogenase activity" RELATED [EC:1.14.21.6] +synonym: "delta7-sterol-C5(6)-desaturase activity" RELATED [EC:1.14.21.6] +synonym: "lathosterol 5-desaturase activity" RELATED [EC:1.14.21.6] +synonym: "lathosterol oxidase activity" EXACT [] +xref: EC:1.14.19.20 +xref: MetaCyc:1.14.21.6-RXN +xref: RHEA:46556 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water +is_a: GO:0070704 ! sterol desaturase activity + +[Term] +id: GO:0050047 +name: leucine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine = (3R)-beta-leucine." [EC:5.4.3.7, RHEA:10284] +synonym: "(2S)-alpha-leucine 2,3-aminomutase activity" RELATED [EC:5.4.3.7] +xref: EC:5.4.3.7 +xref: KEGG_REACTION:R01091 +xref: MetaCyc:LEUCINE-23-AMINOMUTASE-RXN +xref: RHEA:10284 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050048 +name: L-leucine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN] +synonym: "L-leucine aminotransferase activity" BROAD [EC:2.6.1.6] +synonym: "leucine 2-oxoglutarate transaminase activity" RELATED [EC:2.6.1.6] +synonym: "leucine aminotransferase activity" BROAD [] +synonym: "leucine transaminase activity" BROAD [EC:2.6.1.6] +synonym: "leucine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.6] +xref: EC:2.6.1.6 +xref: MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN +xref: RHEA:18321 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050049 +name: leucine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN] +synonym: "L-leucine dehydrogenase activity" RELATED [EC:1.4.1.9] +synonym: "L-leucine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.9] +synonym: "L-leucine:NAD+ oxidoreductase, deaminating" RELATED [EC:1.4.1.9] +synonym: "LeuDH activity" RELATED [EC:1.4.1.9] +xref: EC:1.4.1.9 +xref: MetaCyc:LEUCINE-DEHYDROGENASE-RXN +xref: RHEA:12220 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050050 +name: leucine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)." [EC:2.3.1.66, RHEA:20089] +synonym: "acetyl-CoA:L-leucine N-acetyltransferase activity" RELATED [EC:2.3.1.66] +synonym: "leucine acetyltransferase activity" RELATED [EC:2.3.1.66] +xref: EC:2.3.1.66 +xref: KEGG_REACTION:R01089 +xref: MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:20089 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0050051 +name: leukotriene-B4 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:11461919, PMID:15364545, PMID:8486631, PMID:9675028, RHEA:22176] +synonym: "leukotriene-B4 20-hydroxylase activity" RELATED [EC:1.14.14.94] +synonym: "leukotriene-B4 omega-hydroxylase activity" RELATED [EC:1.14.14.94] +synonym: "LTB(4) 20-hydroxylase activity" RELATED [EC:1.14.14.94] +synonym: "LTB(4) omega-hydroxylase activity" RELATED [EC:1.14.14.94] +synonym: "LTB4 20-hydroxylase activity" RELATED [EC:1.14.14.94] +synonym: "LTB4 omega-hydroxylase activity" RELATED [EC:1.14.14.94] +xref: EC:1.14.14.94 +xref: MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-211873 "CYP4F2, 4F3 20-hydroxylate LTB4" +xref: RHEA:22176 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050052 +name: leukotriene-E4 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+)." [EC:1.14.13.34, RHEA:24120] +synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)" RELATED [EC:1.14.13.34] +synonym: "leukotriene-E(4) omega-hydroxylase activity" RELATED [EC:1.14.13.34] +synonym: "leukotriene-E4 omega-hydroxylase activity" RELATED [EC:1.14.13.34] +synonym: "leukotriene-E4 w-hydroxylase activity" EXACT [] +xref: EC:1.14.13.34 +xref: KEGG_REACTION:R04256 +xref: MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN +xref: RHEA:24120 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050053 +name: levansucrase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN] +synonym: "beta-2,6-fructan:D-glucose 1-fructosyltransferase activity" RELATED [EC:2.4.1.10] +synonym: "beta-2,6-fructosyltransferase activity" RELATED [EC:2.4.1.10] +synonym: "sucrose 6-fructosyl transferase activity" RELATED [EC:2.4.1.10] +synonym: "sucrose 6-fructosyltransferase activity" RELATED [EC:2.4.1.10] +synonym: "sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.10] +xref: EC:2.4.1.10 +xref: MetaCyc:LEVANSUCRASE-RXN +xref: RHEA:13653 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050054 +name: lignostilbene alpha beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin." [EC:1.13.11.43, RHEA:21340] +synonym: "1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving)" RELATED [EC:1.13.11.43] +synonym: "lignostilbene ab-dioxygenase activity" EXACT [] +synonym: "lignostilbene alphabeta-dioxygenase activity" RELATED [EC:1.13.11.43] +xref: EC:1.13.11.43 +xref: KEGG_REACTION:R00043 +xref: MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN +xref: RHEA:21340 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050055 +name: limonin-D-ring-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN] +synonym: "limonin lactone hydrolase activity" RELATED [EC:3.1.1.36] +synonym: "limonin-D-ring-lactone hydrolase activity" RELATED [EC:3.1.1.36] +synonym: "limonoate-D-ring-lactone lactonohydrolase activity" RELATED [EC:3.1.1.36] +xref: EC:3.1.1.36 +xref: MetaCyc:LIMONIN-D-RING-LACTONASE-RXN +xref: RHEA:10896 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050056 +name: linalool 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O." [EC:1.14.14.84, RHEA:32635] +synonym: "3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating)" RELATED [EC:1.14.99.28] +xref: EC:1.14.14.84 +xref: KEGG_REACTION:R04366 +xref: MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN +xref: RHEA:32635 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050057 +name: linamarin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN] +synonym: "UDP glucose ketone cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity" RELATED [EC:2.4.1.63] +synonym: "uridine diphosphoglucose-ketone glucosyltransferase activity" RELATED [EC:2.4.1.63] +xref: EC:2.4.1.63 +xref: MetaCyc:LINAMARIN-SYNTHASE-RXN +xref: RHEA:20009 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050058 +name: linoleate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate." [EC:5.2.1.5, RHEA:17381] +synonym: "linoleate delta12-cis-delta11-trans-isomerase activity" RELATED [EC:5.2.1.5] +synonym: "linoleic acid isomerase activity" RELATED [EC:5.2.1.5] +xref: EC:5.2.1.5 +xref: KEGG_REACTION:R03627 +xref: MetaCyc:LINOLEATE-ISOMERASE-RXN +xref: RHEA:17381 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050059 +name: lombricine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN] +synonym: "ATP:lombricine N-phosphotransferase activity" RELATED [EC:2.7.3.5] +xref: EC:2.7.3.5 +xref: MetaCyc:LOMBRICINE-KINASE-RXN +xref: RHEA:23292 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050060 +name: long-chain-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN] +synonym: "fatty alcohol oxidoreductase activity" RELATED [EC:1.1.1.192] +synonym: "long-chain alcohol dehydrogenase activity" RELATED [EC:1.1.1.192] +synonym: "long-chain-alcohol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.192] +xref: EC:1.1.1.192 +xref: MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN +xref: RHEA:17977 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050061 +name: long-chain-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN] +synonym: "fatty aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.48] +synonym: "long-chain aliphatic aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48] +synonym: "long-chain fatty aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48] +synonym: "long-chain-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.48] +xref: EC:1.2.1.48 +xref: MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN +xref: RHEA:10652 +xref: UM-BBD_reactionID:r1404 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0050062 +name: long-chain-fatty-acyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN] +synonym: "acyl coenzyme A reductase activity" RELATED [EC:1.2.1.50] +synonym: "long-chain fatty acyl CoA reductase activity" EXACT [] +synonym: "long-chain fatty acyl-CoA reductase activity" EXACT [GOC:mah] +synonym: "long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)" RELATED [EC:1.2.1.50] +xref: EC:1.2.1.50 +xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN +xref: RHEA:15437 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050063 +name: obsolete low-density-lipoprotein particle receptor kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN] +comment: This term was made obsolete because it represents a specific gene product. +synonym: "[low-density lipoprotein receptor] kinase activity" EXACT [] +synonym: "ATP:low-density-lipoprotein receptor-L-serine O-phosphotransferase activity" RELATED [EC:2.7.11.29] +synonym: "ATP:low-density-lipoprotein-L-serine O-phosphotransferase activity" RELATED [EC:2.7.11.29] +synonym: "LDL receptor kinase activity" RELATED [EC:2.7.11.29] +synonym: "low-density lipoprotein receptor kinase activity" RELATED [EC:2.7.11.29] +synonym: "low-density-lipoprotein kinase activity" BROAD [EC:2.7.11.29] +synonym: "low-density-lipoprotein receptor kinase (phosphorylating) activity" RELATED [EC:2.7.11.29] +synonym: "low-density-lipoprotein receptor kinase activity" EXACT [GOC:dph] +synonym: "STK7" RELATED [EC:2.7.11.29] +xref: EC:2.7.11.29 +xref: MetaCyc:2.7.11.29-RXN +is_obsolete: true + +[Term] +id: GO:0050064 +name: luteolin 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10568] +synonym: "LGT" RELATED [EC:2.4.1.189] +synonym: "luteolin 7-O-glucoronosyltransferase activity" EXACT [] +synonym: "UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189] +synonym: "UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189] +synonym: "uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity" RELATED [EC:2.4.1.189] +xref: EC:2.4.1.189 +xref: KEGG_REACTION:R03589 +xref: MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN +xref: RHEA:10568 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050065 +name: lysine-pyruvate 6-transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19393] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "L-lysine:pyruvate aminotransferase activity" RELATED [EC:2.6.1.71] +synonym: "Lys-AT" RELATED [EC:2.6.1.71] +synonym: "lysine--pyruvate 6-aminotransferase activity" EXACT [] +synonym: "lysine-pyruvate aminotransferase activity" RELATED [EC:2.6.1.71] +xref: EC:2.6.1.71 +xref: KEGG_REACTION:R00453 +xref: MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN +xref: MetaCyc:PWY-5324 +xref: RHEA:19393 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050066 +name: lysine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." [EC:5.4.3.2, RHEA:19177] +synonym: "L-lysine 2,3-aminomutase activity" RELATED [EC:5.4.3.2] +xref: EC:5.4.3.2 +xref: KEGG_REACTION:R00461 +xref: MetaCyc:LYSINE-23-AMINOMUTASE-RXN +xref: RHEA:19177 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050067 +name: lysine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O." [EC:1.13.12.2, RHEA:14601] +synonym: "L-lysine-2-monooxygenase activity" RELATED [EC:1.13.12.2] +synonym: "L-lysine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.2] +synonym: "lysine monooxygenase activity" RELATED [EC:1.13.12.2] +synonym: "lysine oxygenase activity" RELATED [EC:1.13.12.2] +xref: EC:1.13.12.2 +xref: KEGG_REACTION:R00449 +xref: MetaCyc:LYSINE-2-MONOOXYGENASE-RXN +xref: RHEA:14601 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050068 +name: lysine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate." [EC:2.1.3.8, RHEA:17121] +synonym: "carbamoyl-phosphate:L-lysine carbamoyltransferase activity" RELATED [EC:2.1.3.8] +synonym: "lysine transcarbamylase activity" RELATED [EC:2.1.3.8] +xref: EC:2.1.3.8 +xref: KEGG_REACTION:R01396 +xref: MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN +xref: RHEA:17121 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050069 +name: lysine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN] +synonym: "L-lysine:NAD+ oxidoreductase (deaminating, cyclizing)" RELATED [EC:1.4.1.15] +xref: EC:1.4.1.15 +xref: MetaCyc:LYSINE-DEHYDROGENASE-RXN +xref: RHEA:18505 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050070 +name: lysolecithin acylmutase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24356] +synonym: "lysolecithin 2,3-acylmutase activity" RELATED [EC:5.4.1.1] +synonym: "lysolecithin migratase activity" RELATED [EC:5.4.1.1] +xref: EC:5.4.1.1 +xref: KEGG_REACTION:R03334 +xref: MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN +xref: RHEA:24356 +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0050071 +name: lysyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN] +synonym: "L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity" RELATED [EC:2.3.2.3] +synonym: "L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity" RELATED [EC:2.3.2.3] +xref: EC:2.3.2.3 +xref: MetaCyc:LYSYLTRANSFERASE-RXN +xref: RHEA:10668 +is_a: GO:0016755 ! aminoacyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0050072 +name: m7G(5')pppN diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN] +synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" RELATED [EC:3.6.1.30] +synonym: "decapase activity" RELATED [EC:3.6.1.30] +synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] +synonym: "m7G(5')pppN pyrophosphatase activity" RELATED [EC:3.6.1.30] +xref: EC:3.6.1.30 +xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050073 +name: macrolide 2'-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18333] +synonym: "ATP:macrolide 2'-O-phosphotransferase activity" RELATED [EC:2.7.1.136] +xref: EC:2.7.1.136 +xref: KEGG_REACTION:R03780 +xref: MetaCyc:MACROLIDE-2-KINASE-RXN +xref: RHEA:18333 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050074 +name: malate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN] +synonym: "malate thiokinase activity" RELATED [EC:6.2.1.9] +synonym: "malate:CoA ligase (ADP-forming)" RELATED [EC:6.2.1.9] +synonym: "malyl coenzyme A synthetase activity" RELATED [EC:6.2.1.9] +synonym: "malyl-CoA synthetase activity" RELATED [EC:6.2.1.9] +xref: EC:6.2.1.9 +xref: MetaCyc:MALATE--COA-LIGASE-RXN +xref: RHEA:26193 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050075 +name: maleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-malate = H(2)O + maleate." [EC:4.2.1.31, RHEA:23692] +synonym: "(R)-malate hydro-lyase (maleate-forming)" RELATED [EC:4.2.1.31] +synonym: "(R)-malate hydro-lyase activity" RELATED [EC:4.2.1.31] +synonym: "D-malate hydro-lyase activity" RELATED [EC:4.2.1.31] +synonym: "malease activity" RELATED [EC:4.2.1.31] +xref: EC:4.2.1.31 +xref: KEGG_REACTION:R02419 +xref: MetaCyc:MALEATE-HYDRATASE-RXN +xref: RHEA:23692 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050076 +name: maleate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: maleate = fumarate." [EC:5.2.1.1, RHEA:13169] +synonym: "maleate cis-trans-isomerase activity" RELATED [EC:5.2.1.1] +xref: EC:5.2.1.1 +xref: KEGG_REACTION:R01087 +xref: MetaCyc:MALEATE-ISOMERASE-RXN +xref: RHEA:13169 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050077 +name: maleylpyruvate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN] +synonym: "3-maleylpyruvate cis-trans-isomerase activity" RELATED [EC:5.2.1.4] +xref: EC:5.2.1.4 +xref: MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN +xref: RHEA:17393 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050078 +name: malonate CoA-transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18817] +synonym: "acetyl-CoA:malonate CoA-transferase activity" RELATED [EC:2.8.3.3] +synonym: "malonate coenzyme A-transferase activity" RELATED [EC:2.8.3.3] +xref: EC:2.8.3.3 +xref: KEGG_REACTION:R00743 +xref: MetaCyc:MALONATE-COA-TRANSFERASE-RXN +xref: RHEA:18817 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0050079 +name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate +namespace: molecular_function +alt_id: GO:0047607 +def: "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN] +comment: Note that this function was formerly EC:4.2.1.71. +synonym: "3-oxopropanoate hydro-lyase (propynoate-forming)" RELATED [EC:4.2.1.27] +synonym: "3-oxopropanoate hydro-lyase activity" RELATED [EC:4.2.1.27] +synonym: "acetylenecarboxylate hydratase activity" BROAD [] +synonym: "acetylenecarboxylate hydratase activity, producing malonate-semialdehyde" EXACT [] +synonym: "acetylenemonocarboxylate hydrase activity" RELATED [EC:4.2.1.27] +synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] +synonym: "acetylmonocarboxylic acid hydrase activity" RELATED [EC:4.2.1.27] +synonym: "alkynoate hydratase activity" BROAD [] +synonym: "malonate-semialdehyde dehydratase activity" EXACT [] +xref: EC:4.2.1.27 +xref: MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN +xref: RHEA:17957 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050080 +name: malonyl-CoA decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN] +synonym: "malonyl coenzyme A decarboxylase activity" RELATED [EC:4.1.1.9] +synonym: "malonyl-CoA carboxy-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.1.9] +synonym: "malonyl-CoA carboxy-lyase activity" RELATED [EC:4.1.1.9] +xref: EC:4.1.1.9 +xref: MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN +xref: Reactome:R-HSA-977317 "malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome" +xref: RHEA:18781 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050081 +name: maltose-6'-phosphate glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN] +synonym: "maltose-6'-phosphate 6-phosphoglucohydrolase activity" RELATED [EC:3.2.1.122] +synonym: "phospho-alpha-glucosidase activity" RELATED [EC:3.2.1.122] +xref: EC:3.2.1.122 +xref: MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN +xref: RHEA:20421 +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0050082 +name: maltose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN] +synonym: "maltose:phosphate 1-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.8] +xref: EC:2.4.1.8 +xref: MetaCyc:MALTOSE-PHOSPHORYLASE-RXN +xref: RHEA:21116 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0050083 +name: malyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN] +synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)" RELATED [EC:4.1.3.24] +synonym: "(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity" RELATED [EC:4.1.3.24] +synonym: "malyl-coenzyme A lyase activity" RELATED [EC:4.1.3.24] +xref: EC:4.1.3.24 +xref: MetaCyc:MALYL-COA-LYASE-RXN +xref: RHEA:16629 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0050084 +name: mannitol-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate." [EC:3.1.3.22, RHEA:19537] +synonym: "D-mannitol-1-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.22] +synonym: "mannitol-1-phosphate phosphatase activity" RELATED [EC:3.1.3.22] +xref: EC:3.1.3.22 +xref: KEGG_REACTION:R02167 +xref: MetaCyc:MANNITOL-1-PHOSPHATASE-RXN +xref: RHEA:19537 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050085 +name: mannitol 2-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH." [EC:1.1.1.138, RHEA:16765] +synonym: "D-mannitol:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.138] +synonym: "NADP-dependent mannitol dehydrogenase activity" RELATED [EC:1.1.1.138] +xref: EC:1.1.1.138 +xref: KEGG_REACTION:R00870 +xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN +xref: RHEA:16765 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050086 +name: mannitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN] +synonym: "D-mannitol dehydrogenase activity" RELATED [EC:1.1.1.67] +synonym: "D-mannitol:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.67] +xref: EC:1.1.1.67 +xref: MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN +xref: RHEA:12084 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050087 +name: mannitol dehydrogenase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+." [RHEA:17597] +synonym: "D-mannitol:ferricytochrome-c 2-oxidoreductase activity" RELATED [] +synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.2.2] +xref: EC:1.1.2.2 +xref: MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN +xref: RHEA:17597 +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0050088 +name: mannose-6-phosphate 6-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH." [EC:1.1.1.224, RHEA:14925] +synonym: "6-phosphomannose reductase activity" RELATED [EC:1.1.1.224] +synonym: "D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity" RELATED [EC:1.1.1.224] +synonym: "mannose-6-phosphate reductase activity" RELATED [EC:1.1.1.224] +synonym: "NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity" RELATED [EC:1.1.1.224] +synonym: "NADPH-dependent M6P reductase activity" RELATED [EC:1.1.1.224] +synonym: "NADPH-dependent mannose 6-phosphate reductase activity" RELATED [EC:1.1.1.224] +synonym: "NADPH-mannose-6-P reductase activity" RELATED [EC:1.1.1.224] +xref: EC:1.1.1.224 +xref: KEGG_REACTION:R01817 +xref: MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN +xref: RHEA:14925 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050089 +name: mannose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannose = D-fructose." [EC:5.3.1.7, RHEA:22604] +synonym: "D-mannose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.7] +synonym: "D-mannose isomerase activity" RELATED [EC:5.3.1.7] +synonym: "D-mannose ketol-isomerase activity" RELATED [EC:5.3.1.7] +xref: EC:5.3.1.7 +xref: KEGG_REACTION:R00877 +xref: MetaCyc:MANNOSE-ISOMERASE-RXN +xref: RHEA:22604 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050090 +name: mannuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN] +synonym: "D-mannonate:NAD(P)+ 6-oxidoreductase activity" RELATED [EC:1.1.1.131] +synonym: "D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))" RELATED [EC:1.1.1.131] +synonym: "mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity" RELATED [EC:1.1.1.131] +synonym: "mannonate dehydrogenase (NAD(P)+)" RELATED [EC:1.1.1.131] +synonym: "mannonate dehydrogenase activity" RELATED [EC:1.1.1.131] +xref: EC:1.1.1.131 +xref: MetaCyc:MANNURONATE-REDUCTASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050091 +name: melilotate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)." [EC:1.14.13.4, RHEA:17669] +synonym: "2-hydroxyphenylpropionate hydroxylase activity" RELATED [EC:1.14.13.4] +synonym: "2-hydroxyphenylpropionic hydroxylase activity" RELATED [EC:1.14.13.4] +synonym: "3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.13.4] +synonym: "melilotate hydroxylase activity" EXACT [] +synonym: "melilotic hydroxylase activity" RELATED [EC:1.14.13.4] +xref: EC:1.14.13.4 +xref: KEGG_REACTION:R03369 +xref: MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN +xref: RHEA:17669 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050092 +name: meso-tartrate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." [EC:1.3.1.7, RHEA:18553] +synonym: "meso-tartrate:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.7] +xref: EC:1.3.1.7 +xref: KEGG_REACTION:R02544 +xref: MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN +xref: RHEA:18553 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050093 +name: methanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19401] +synonym: "methanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.244] +xref: EC:1.1.1.244 +xref: KEGG_REACTION:R00605 +xref: MetaCyc:METHANOL-DEHYDROGENASE-RXN +xref: RHEA:19401 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050094 +name: methionine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22884] +synonym: "L-methionine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.73] +synonym: "methionine-glyoxylate aminotransferase activity" RELATED [EC:2.6.1.73] +synonym: "MGAT activity" RELATED [EC:2.6.1.73] +xref: EC:2.6.1.73 +xref: KEGG_REACTION:R00652 +xref: MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN +xref: RHEA:22884 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050095 +name: methionine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2)." [EC:4.1.1.57, RHEA:17757] +synonym: "L-methionine carboxy-lyase (3-methylthiopropanamine-forming)" RELATED [EC:4.1.1.57] +synonym: "L-methionine carboxy-lyase activity" RELATED [EC:4.1.1.57] +synonym: "L-methionine decarboxylase activity" RELATED [EC:4.1.1.57] +xref: EC:4.1.1.57 +xref: KEGG_REACTION:R00656 +xref: MetaCyc:METHIONINE-DECARBOXYLASE-RXN +xref: RHEA:17757 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050096 +name: methylaspartate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+)." [EC:4.3.1.2, RHEA:12829] +synonym: "3-methylaspartase activity" RELATED [EC:4.3.1.2] +synonym: "beta-methylaspartase activity" RELATED [EC:4.3.1.2] +synonym: "L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)" RELATED [EC:4.3.1.2] +synonym: "L-threo-3-methylaspartate ammonia-lyase activity" RELATED [EC:4.3.1.2] +xref: EC:4.3.1.2 +xref: KEGG_REACTION:R03696 +xref: MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN +xref: RHEA:12829 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0050097 +name: methylaspartate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate." [EC:5.4.99.1, RHEA:12857] +synonym: "b-methylaspartate-glutamate mutase activity" RELATED [EC:5.4.99.1] +synonym: "beta-methylaspartate-glutamate mutase activity" RELATED [EC:5.4.99.1] +synonym: "glutamate isomerase activity" RELATED [EC:5.4.99.1] +synonym: "glutamate mutase activity" RELATED [EC:5.4.99.1] +synonym: "glutamic acid isomerase activity" RELATED [EC:5.4.99.1] +synonym: "glutamic acid mutase activity" RELATED [EC:5.4.99.1] +synonym: "glutamic isomerase activity" RELATED [EC:5.4.99.1] +synonym: "glutamic mutase activity" RELATED [EC:5.4.99.1] +synonym: "L-threo-3-methylaspartate carboxy-aminomethylmutase activity" RELATED [EC:5.4.99.1] +synonym: "methylaspartic acid mutase activity" RELATED [EC:5.4.99.1] +xref: EC:5.4.99.1 +xref: KEGG_REACTION:R00262 +xref: MetaCyc:METHYLASPARTATE-MUTASE-RXN +xref: RHEA:12857 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050098 +name: methylguanidinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11764] +synonym: "methylguanidine amidinohydrolase activity" RELATED [EC:3.5.3.16] +synonym: "methylguanidine hydrolase activity" RELATED [EC:3.5.3.16] +xref: EC:3.5.3.16 +xref: KEGG_REACTION:R01589 +xref: MetaCyc:METHYLGUANIDINASE-RXN +xref: RHEA:11764 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050099 +name: methylglutamate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22572] +synonym: "N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)" RELATED [EC:1.5.99.5] +synonym: "N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)" RELATED [EC:1.5.99.5] +synonym: "N-methylglutamate dehydrogenase activity" RELATED [EC:1.5.99.5] +xref: EC:1.5.99.5 +xref: KEGG_REACTION:R00609 +xref: MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN +xref: RHEA:22572 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050100 +name: methylitaconate delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [EC:5.3.3.6, RHEA:23480] +synonym: "methylitaconate D-isomerase activity" EXACT [] +synonym: "methylitaconate delta2-delta3-isomerase activity" RELATED [EC:5.3.3.6] +synonym: "methylitaconate isomerase activity" RELATED [EC:5.3.3.6] +xref: EC:5.3.3.6 +xref: KEGG_REACTION:R03070 +xref: MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN +xref: RHEA:23480 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050101 +name: mimosinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, RHEA:13373] +synonym: "mimosine amidohydrolase activity" RELATED [EC:3.5.1.61] +xref: EC:3.5.1.61 +xref: KEGG_REACTION:R04350 +xref: MetaCyc:MIMOSINASE-RXN +xref: RHEA:13373 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050102 +name: cellodextrin phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN] +synonym: "1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.49] +synonym: "beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity" RELATED [EC:2.4.1.49] +xref: EC:2.4.1.49 +xref: MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN +xref: RHEA:23024 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050103 +name: dextrin dextranase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN] +synonym: "1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" RELATED [EC:2.4.1.2] +synonym: "dextran dextrinase activity" RELATED [EC:2.4.1.2] +synonym: "dextrin 6-glucosyltransferase activity" RELATED [EC:2.4.1.2] +xref: EC:2.4.1.2 +xref: MetaCyc:DEXTRIN-DEXTRANASE-RXN +xref: RHEA:14625 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050104 +name: L-gulonate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH." [EC:1.1.1.45, RHEA:12889] +synonym: "L-3-aldonate dehydrogenase activity" RELATED [EC:1.1.1.45] +synonym: "L-3-aldonic dehydrogenase activity" RELATED [EC:1.1.1.45] +synonym: "L-3-hydroxyacid dehydrogenase activity" RELATED [EC:1.1.1.45] +synonym: "L-beta-hydroxy-acid-NAD-oxidoreductase activity" RELATED [EC:1.1.1.45] +synonym: "L-beta-hydroxyacid dehydrogenase activity" RELATED [EC:1.1.1.45] +synonym: "L-gulonate:NAD+ 3-oxidoreductase activity" RELATED [EC:1.1.1.45] +synonym: "L-gulonic acid dehydrogenase activity" RELATED [EC:1.1.1.45] +xref: EC:1.1.1.45 +xref: KEGG_REACTION:R02640 +xref: MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN +xref: Reactome:R-HSA-5661290 "CRYL1 dimer dehydrogenates L-gulonate to 3-dehydro-L-gulonate" +xref: RHEA:12889 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050105 +name: L-gulonolactone oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN, RHEA:32363] +synonym: "GLO activity" RELATED [EC:1.1.3.8] +synonym: "L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity" RELATED [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone oxidase activity" RELATED [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone:O2 oxidoreductase activity" RELATED [EC:1.1.3.8] +synonym: "L-gulono-gamma-lactone:oxidoreductase activity" RELATED [EC:1.1.3.8] +xref: EC:1.1.3.8 +xref: MetaCyc:L-GULONOLACTONE-OXIDASE-RXN +xref: RHEA:32363 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050106 +name: monomethyl-sulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate." [EC:3.1.6.16, RHEA:14221] +synonym: "monomethyl-sulfate sulfohydrolase activity" RELATED [EC:3.1.6.16] +synonym: "monomethyl-sulphatase activity" EXACT [] +xref: EC:3.1.6.16 +xref: KEGG_REACTION:R01145 +xref: MetaCyc:MONOMETHYL-SULFATASE-RXN +xref: RHEA:14221 +is_a: GO:0008484 ! sulfuric ester hydrolase activity + +[Term] +id: GO:0050107 +name: monoterpenol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:monoterpenol O-acetyltransferase activity" RELATED [EC:2.3.1.69] +synonym: "menthol transacetylase activity" NARROW [EC:2.3.1.69] +xref: EC:2.3.1.69 +xref: MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050108 +name: monoterpenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN] +synonym: "bornyl diphosphate hydrolase activity" RELATED [EC:3.1.7.3] +synonym: "bornyl pyrophosphate hydrolase activity" RELATED [EC:3.1.7.3] +synonym: "monoterpenyl-diphosphate diphosphohydrolase activity" RELATED [EC:3.1.7.3] +synonym: "monoterpenyl-pyrophosphatase activity" EXACT [] +xref: EC:3.1.7.3 +xref: MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0050109 +name: morphine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN] +synonym: "morphine:NAD(P)+ 6-oxidoreductase activity" RELATED [EC:1.1.1.218] +synonym: "naloxone reductase activity" RELATED [EC:1.1.1.218] +synonym: "reductase, naloxone" RELATED [EC:1.1.1.218] +xref: EC:1.1.1.218 +xref: MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050110 +name: mucinaminylserine mucinaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [MetaCyc:3.2.1.110-RXN] +synonym: "D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity" RELATED [EC:3.2.1.110] +synonym: "endo-beta-N-acetyl-D-galactosaminidase activity" BROAD [EC:3.2.1.110] +synonym: "endo-beta-N-acetylgalactosaminidase" BROAD [EC:3.2.1.110] +xref: EC:3.2.1.97 +xref: KEGG_REACTION:R04527 +xref: MetaCyc:3.2.1.110-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050111 +name: mycocerosate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10588] +synonym: "acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)" RELATED [EC:2.3.1.111] +synonym: "mycocerosic acid synthase activity" RELATED [EC:2.3.1.111] +xref: EC:2.3.1.111 +xref: KEGG_REACTION:R05189 +xref: MetaCyc:MYCOCEROSATE-SYNTHASE-RXN +xref: RHEA:10588 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050112 +name: inositol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16949] +synonym: "inositol:NAD 2-dehydrogenase activity" EXACT [] +synonym: "myo-inositol 2-dehydrogenase activity" EXACT [] +xref: EC:1.1.1.18 +xref: KEGG_REACTION:R01183 +xref: MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN +xref: RHEA:16949 +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0050113 +name: inositol oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [RHEA:23696] +synonym: "meso-inositol oxygenase activity" RELATED [EC:1.13.99.1] +synonym: "MOO activity" RELATED [EC:1.13.99.1] +synonym: "myo-inositol oxygenase activity" EXACT [] +synonym: "myo-inositol:oxygen oxidoreductase activity" RELATED [EC:1.13.99.1] +xref: EC:1.13.99.1 +xref: KEGG_REACTION:R01184 +xref: MetaCyc:MYO-INOSITOL-OXYGENASE-RXN +xref: Reactome:R-HSA-5678327 "MIOX oxidises Ins to GlcA" +xref: RHEA:23696 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0050114 +name: myo-inosose-2 dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O." [EC:4.2.1.44, RHEA:14065] +synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)" RELATED [EC:4.2.1.44] +synonym: "2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity" RELATED [EC:4.2.1.44] +synonym: "inosose 2,3-dehydratase activity" RELATED [EC:4.2.1.44] +synonym: "ketoinositol dehydratase activity" RELATED [EC:4.2.1.44] +xref: EC:4.2.1.44 +xref: KEGG_REACTION:R02782 +xref: MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN +xref: RHEA:14065 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050115 +name: myosin-light-chain-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN] +synonym: "[Myosin light-chain]-phosphatase activity" EXACT [] +synonym: "myosin light chain kinase phosphatase activity" RELATED [EC:3.1.3.53] +synonym: "myosin light-chain kinase phosphatase activity" RELATED [EC:3.1.3.53] +synonym: "myosin-light-chain phosphatase activity" RELATED [EC:3.1.3.53] +synonym: "myosin-light-chain-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.53] +synonym: "protein phosphatase 2A" RELATED [EC:3.1.3.53] +xref: EC:3.1.3.53 +xref: MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN +xref: Reactome:R-HSA-419232 "Myosin phosphatase dephosphorylates myosin regulatory light chain" +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0050116 +name: N,N-dimethylformamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19517] +synonym: "dimethylformamidase activity" RELATED [EC:3.5.1.56] +synonym: "DMFase activity" RELATED [EC:3.5.1.56] +synonym: "N,N-dimethylformamide amidohydrolase activity" RELATED [EC:3.5.1.56] +xref: EC:3.5.1.56 +xref: KEGG_REACTION:R02509 +xref: MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN +xref: RHEA:19517 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050117 +name: N-acetyl-beta-alanine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23212] +synonym: "N-acetyl-beta-alanine amidohydrolase activity" RELATED [EC:3.5.1.21] +xref: EC:3.5.1.21 +xref: KEGG_REACTION:R00909 +xref: MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN +xref: RHEA:23212 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050118 +name: N-acetyldiaminopimelate deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate." [EC:3.5.1.47, RHEA:20405] +synonym: "6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.47] +synonym: "N-acetyl-L-diaminopimelic acid deacylase activity" RELATED [EC:3.5.1.47] +synonym: "N-acetyl-LL-diaminopimelate deacylase activity" RELATED [EC:3.5.1.47] +synonym: "N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" RELATED [EC:3.5.1.47] +xref: EC:3.5.1.47 +xref: KEGG_REACTION:R02733 +xref: MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN +xref: RHEA:20405 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050119 +name: N-acetylglucosamine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20593] +synonym: "acetylaminodeoxyglucose acetylhydrolase activity" RELATED [EC:3.5.1.33] +synonym: "N-acetyl-D-glucosamine amidohydrolase activity" RELATED [EC:3.5.1.33] +synonym: "N-acetyl-D-glucosaminyl N-deacetylase activity" RELATED [EC:3.5.1.33] +xref: EC:3.5.1.33 +xref: KEGG_REACTION:R01200 +xref: MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN +xref: Reactome:R-HSA-2022887 "NDST1-4 N-deacetylates GlcNAc residues in heparan" +xref: RHEA:20593 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0050120 +name: N-acetylhexosamine 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH." [EC:1.1.1.240, RHEA:23144] +synonym: "N-acetyl-D-hexosamine dehydrogenase activity" RELATED [EC:1.1.1.240] +synonym: "N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.240] +synonym: "N-acetylhexosamine dehydrogenase activity" RELATED [EC:1.1.1.240] +xref: EC:1.1.1.240 +xref: KEGG_REACTION:R01202 +xref: MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN +xref: RHEA:23144 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050121 +name: N-acylglucosamine 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN] +synonym: "acylglucosamine 2-epimerase activity" RELATED [EC:5.1.3.8] +synonym: "GlcNAc 2-epimerase activity" RELATED [EC:5.1.3.8] +synonym: "N-acetyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.8] +synonym: "N-acetylglucosamine 2-epimerase activity" RELATED [EC:5.1.3.8] +synonym: "N-acyl-D-glucosamine 2-epimerase activity" RELATED [EC:5.1.3.8] +xref: EC:5.1.3.8 +xref: MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN +xref: Reactome:R-HSA-6803761 "RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc" +xref: RHEA:19033 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050122 +name: N-acylhexosamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+)." [EC:1.1.3.29, RHEA:13029] +synonym: "N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.29] +synonym: "N-acyl-D-hexosamine oxidase activity" RELATED [EC:1.1.3.29] +synonym: "N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity" RELATED [EC:1.1.3.29] +xref: EC:1.1.3.29 +xref: KEGG_REACTION:R01203 +xref: MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN +xref: RHEA:13029 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050123 +name: N-acylmannosamine 1-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH." [EC:1.1.1.233, RHEA:11540] +synonym: "N-acetyl-D-mannosamine dehydrogenase activity" RELATED [EC:1.1.1.233] +synonym: "N-acyl-D-mannosamine dehydrogenase activity" RELATED [EC:1.1.1.233] +synonym: "N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.233] +synonym: "N-acylmannosamine dehydrogenase activity" RELATED [EC:1.1.1.233] +xref: EC:1.1.1.233 +xref: KEGG_REACTION:R02651 +xref: MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN +xref: RHEA:11540 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050124 +name: N-acylneuraminate-9-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN] +synonym: "acylneuraminate 9-phosphatase activity" RELATED [EC:3.1.3.29] +synonym: "N-acylneuraminate-9-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.29] +synonym: "N-acylneuraminic (sialic) acid 9-phosphatase activity" RELATED [EC:3.1.3.29] +synonym: "N-acylneuraminic acid 9-phosphate phosphatase activity" RELATED [EC:3.1.3.29] +xref: EC:3.1.3.29 +xref: MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN +xref: Reactome:R-HSA-4084989 "NANP dephosphorylates Neu5Ac-9-P to Neu5Ac" +xref: RHEA:13057 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050125 +name: N-benzyloxycarbonylglycine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine." [EC:3.5.1.58, RHEA:20900] +synonym: "benzyloxycarbonylglycine hydrolase activity" RELATED [EC:3.5.1.58] +synonym: "N-benzyloxycarbonylglycine urethanehydrolase activity" RELATED [EC:3.5.1.58] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity" RELATED [EC:3.5.1.58] +synonym: "nalpha-benzyloxycarbonyl amino acid urethane hydrolase I" RELATED [EC:3.5.1.58] +synonym: "nalpha-carbobenzoxyamino acid amidohydrolase activity" RELATED [EC:3.5.1.58] +xref: EC:3.5.1.58 +xref: KEGG_REACTION:R02551 +xref: MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN +xref: RHEA:20900 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050126 +name: N-carbamoylputrescine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine." [EC:3.5.1.53, RHEA:22284] +synonym: "carbamoylputrescine hydrolase activity" RELATED [EC:3.5.1.53] +synonym: "N-carbamoylputrescine amidohydrolase activity" RELATED [EC:3.5.1.53] +synonym: "NCP" RELATED [EC:3.5.1.53] +xref: EC:3.5.1.53 +xref: KEGG_REACTION:R01152 +xref: MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN +xref: RHEA:22284 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050127 +name: N-carbamoylsarcosine amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine." [EC:3.5.1.59, RHEA:20057] +synonym: "carbamoylsarcosine amidase activity" RELATED [EC:3.5.1.59] +synonym: "CSHase activity" RELATED [EC:3.5.1.59] +synonym: "N-carbamoylsarcosine amidohydrolase activity" RELATED [EC:3.5.1.59] +xref: EC:3.5.1.59 +xref: KEGG_REACTION:R01563 +xref: MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN +xref: RHEA:20057 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050128 +name: N-feruloylglycine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine." [EC:3.5.1.71, RHEA:10484] +synonym: "N-feruloylglycine amidohydrolase activity" RELATED [EC:3.5.1.71] +synonym: "N-feruloylglycine hydrolase activity" RELATED [EC:3.5.1.71] +xref: EC:3.5.1.71 +xref: KEGG_REACTION:R03579 +xref: MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN +xref: RHEA:10484 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050129 +name: N-formylglutamate deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12476] +synonym: "beta-citryl-L-glutamate amidase activity" RELATED [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate hydrolase activity" RELATED [EC:3.5.1.68] +synonym: "beta-citryl-L-glutamate-hydrolyzing enzyme" RELATED [EC:3.5.1.68] +synonym: "beta-citrylglutamate amidase activity" RELATED [EC:3.5.1.68] +synonym: "formylglutamate deformylase activity" RELATED [EC:3.5.1.68] +synonym: "N-formyl-L-glutamate amidohydrolase activity" RELATED [EC:3.5.1.68] +synonym: "N-formylglutamate hydrolase activity" RELATED [EC:3.5.1.68] +xref: EC:3.5.1.68 +xref: KEGG_REACTION:R00525 +xref: MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN +xref: RHEA:12476 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050130 +name: N-methyl-2-oxoglutaramate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24108] +synonym: "5-hydroxy-N-methylpyroglutamate synthase activity" RELATED [EC:3.5.1.36] +synonym: "N-methyl-2-oxoglutaramate methylamidohydrolase activity" RELATED [EC:3.5.1.36] +xref: EC:3.5.1.36 +xref: KEGG_REACTION:R01587 +xref: MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN +xref: RHEA:24108 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050131 +name: N-methyl-L-amino-acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN] +synonym: "N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.2] +synonym: "N-methylamino acid oxidase activity" RELATED [EC:1.5.3.2] +xref: EC:1.5.3.2 +xref: MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN +xref: RHEA:11472 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050132 +name: N-methylalanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21768] +synonym: "N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating)" RELATED [EC:1.4.1.17] +xref: EC:1.4.1.17 +xref: KEGG_REACTION:R01584 +xref: MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN +xref: RHEA:21768 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050133 +name: N6-hydroxylysine O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22388] +synonym: "acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity" RELATED [EC:2.3.1.102] +synonym: "acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity" RELATED [EC:2.3.1.102] +synonym: "N(6)-hydroxylysine acetylase activity" RELATED [EC:2.3.1.102] +synonym: "N6-hydroxylysine acetylase activity" RELATED [EC:2.3.1.102] +synonym: "N6-hydroxylysine:acetyl CoA N6-transacetylase activity" RELATED [EC:2.3.1.102] +xref: EC:2.3.1.102 +xref: KEGG_REACTION:R03168 +xref: MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN +xref: RHEA:22388 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050134 +name: N6-methyl-lysine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2)." [EC:1.5.3.4, RHEA:23200] +synonym: "6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.4] +synonym: "epsilon-alkyl-L-lysine:oxygen oxidoreductase activity" RELATED [EC:1.5.3.4] +synonym: "epsilon-alkyllysinase activity" RELATED [EC:1.5.3.4] +synonym: "epsilon-N-methyllysine demethylase activity" RELATED [EC:1.5.3.4] +synonym: "N(6)-methyllysine oxidase activity" RELATED [EC:1.5.3.4] +synonym: "N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)" RELATED [EC:1.5.3.4] +synonym: "N6-methyllysine oxidase activity" RELATED [EC:1.5.3.4] +xref: EC:1.5.3.4 +xref: KEGG_REACTION:R00612 +xref: MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN +xref: RHEA:23200 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0050135 +name: NAD(P)+ nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN] +synonym: "NAD(P) nucleosidase activity" EXACT [] +synonym: "NAD(P)(+) nucleosidase activity" EXACT [] +synonym: "NAD(P)+ glycohydrolase activity" RELATED [EC:3.2.2.6] +synonym: "NAD(P)ase activity" RELATED [EC:3.2.2.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity" RELATED [EC:3.2.2.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) nucleosidase activity" RELATED [EC:3.2.2.6] +synonym: "triphosphopyridine nucleotidase activity" RELATED [EC:3.2.2.6] +xref: EC:3.2.2.6 +xref: MetaCyc:NADP+-NUCLEOSIDASE-RXN +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0050136 +name: NADH dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.5.11, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN] +synonym: "D-diaphorase activity" RELATED [EC:1.6.5.11] +synonym: "DPNH-menadione reductase activity" RELATED [EC:1.6.5.11] +synonym: "NADH-quinone oxidoreductase activity" RELATED [EC:1.6.5.11] +synonym: "NADH:(quinone-acceptor) oxidoreductase activity" RELATED [EC:1.6.5.11] +synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" RELATED [EC:1.6.99.5] +xref: EC:1.6.5.11 +xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN +xref: RHEA:46160 +is_a: GO:0003954 ! NADH dehydrogenase activity +is_a: GO:0003955 ! NAD(P)H dehydrogenase (quinone) activity + +[Term] +id: GO:0050137 +name: NADPH peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+)." [EC:1.11.1.2, RHEA:15173] +synonym: "NADP peroxidase activity" RELATED [EC:1.11.1.2] +synonym: "NADPH:hydrogen-peroxide oxidoreductase activity" RELATED [EC:1.11.1.2] +synonym: "nicotinamide adenine dinucleotide phosphate peroxidase activity" RELATED [EC:1.11.1.2] +synonym: "TPN peroxidase activity" RELATED [EC:1.11.1.2] +synonym: "TPNH peroxidase activity" RELATED [EC:1.11.1.2] +synonym: "triphosphopyridine nucleotide peroxidase activity" RELATED [EC:1.11.1.2] +xref: EC:1.11.1.2 +xref: KEGG_REACTION:R00113 +xref: MetaCyc:NADPH-PEROXIDASE-RXN +xref: RHEA:15173 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0050138 +name: nicotinate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH." [EC:1.17.1.5, RHEA:12236] +synonym: "nicotinate hydroxylase activity" RELATED [EC:1.17.1.5] +synonym: "nicotinate:NADP+ 6-oxidoreductase (hydroxylating)" RELATED [EC:1.17.1.5] +synonym: "nicotinic acid hydroxylase activity" RELATED [EC:1.17.1.5] +xref: EC:1.17.1.5 +xref: KEGG_REACTION:R01720 +xref: MetaCyc:NICOTINATE-DEHYDROGENASE-RXN +xref: MetaCyc:RXN-7637 +xref: RHEA:12236 +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0050139 +name: nicotinate-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19437] +synonym: "nicotinate glucosyltransferase activity" BROAD [] +synonym: "UDP-glucose:nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196] +synonym: "UDP-glucose:nicotinic acid-N-glucosyltransferase activity" RELATED [EC:2.4.1.196] +synonym: "UDPglucose:nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196] +synonym: "uridine diphosphoglucose-nicotinate N-glucosyltransferase activity" RELATED [EC:2.4.1.196] +xref: EC:2.4.1.196 +xref: KEGG_REACTION:R01722 +xref: MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:19437 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050140 +name: nitrate reductase (cytochrome) activity +namespace: molecular_function +def: "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN] +synonym: "benzyl viologen-nitrate reductase activity" RELATED [EC:1.9.6.1] +synonym: "ferrocytochrome:nitrate oxidoreductase activity" RELATED [EC:1.9.6.1] +xref: EC:1.9.6.1 +xref: MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN +xref: RHEA:12909 +is_a: GO:0016677 ! oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor + +[Term] +id: GO:0050141 +name: nitroethane oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN] +synonym: "nitroethane reductase activity" RELATED [EC:1.7.3.1] +synonym: "nitroethane:oxygen oxidoreductase activity" RELATED [EC:1.7.3.1] +xref: EC:1.7.3.1 +xref: MetaCyc:NITROETHANE-OXIDASE-RXN +is_a: GO:0052664 ! nitroalkane oxidase activity + +[Term] +id: GO:0050142 +name: nitrogenase (flavodoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN] +synonym: "reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)" RELATED [EC:1.19.6.1] +xref: EC:1.19.6.1 +xref: MetaCyc:NITROGENASE-FLAVODOXIN-RXN +xref: RHEA:15645 +is_a: GO:0016738 ! oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor + +[Term] +id: GO:0050143 +name: nocardicin-A epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: isonocardicin A = nocardicin A." [EC:5.1.1.14, RHEA:22792] +synonym: "isonocardicin A epimerase activity" RELATED [EC:5.1.1.14] +xref: EC:5.1.1.14 +xref: KEGG_REACTION:R03073 +xref: MetaCyc:NOCARDICIN-A-EPIMERASE-RXN +xref: RHEA:22792 +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0050144 +name: nucleoside deoxyribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN] +synonym: "deoxyribose transferase activity" RELATED [EC:2.4.2.6] +synonym: "nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases)" RELATED [EC:2.4.2.6] +synonym: "nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]" RELATED [EC:2.4.2.6] +synonym: "nucleoside trans-N-deoxyribosylase activity" RELATED [EC:2.4.2.6] +synonym: "nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity" RELATED [EC:2.4.2.6] +synonym: "purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity" RELATED [EC:2.4.2.6] +synonym: "trans-deoxyribosylase activity" RELATED [EC:2.4.2.6] +synonym: "trans-N-deoxyribosylase activity" RELATED [EC:2.4.2.6] +synonym: "trans-N-glycosidase activity" RELATED [EC:2.4.2.6] +xref: EC:2.4.2.6 +xref: MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0050145 +name: nucleoside monophosphate kinase activity +namespace: molecular_function +alt_id: GO:0019201 +def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732] +synonym: "ATP:nucleoside-phosphate phosphotransferase activity" RELATED [EC:2.7.4.4] +synonym: "NMP-kinase activity" RELATED [EC:2.7.4.4] +synonym: "nucleoside-phosphate kinase activity" EXACT [] +synonym: "nucleotide kinase activity" RELATED [] +xref: EC:2.7.4.4 +xref: MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN +xref: Reactome:R-HSA-2162092 "carbovir monophosphate + ATP => carbovir diphosphate + ADP" +xref: Reactome:R-HSA-6788798 "AK4 phosphorylates (d)NMPs to (d)NDPs" +xref: Reactome:R-HSA-6788810 "AK6 phosphorylates (d)NMPs to (d)NDPs" +xref: Reactome:R-HSA-73548 "(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)" +xref: Reactome:R-HSA-73635 "dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]" +xref: Reactome:R-HSA-75125 "(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1)" +xref: Reactome:R-HSA-75126 "dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]" +xref: RHEA:24036 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0050146 +name: nucleoside phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN] +synonym: "nonspecific nucleoside phosphotransferase activity" RELATED [EC:2.7.1.77] +synonym: "nucleotide:2'-nucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77] +synonym: "nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77] +synonym: "nucleotide:nucleoside 5'-phosphotransferase activity" RELATED [EC:2.7.1.77] +xref: EC:2.7.1.77 +xref: MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN +xref: Reactome:R-HSA-2162066 "carbovir + IMP => carbovir monophosphate + inosine" +xref: RHEA:19961 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0050147 +name: nucleoside ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN] +synonym: "nucleoside N-ribosyltransferase activity" RELATED [EC:2.4.2.5] +synonym: "nucleoside:purine(pyrimidine) D-ribosyltransferase activity" RELATED [EC:2.4.2.5] +xref: EC:2.4.2.5 +xref: MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0050148 +name: nucleotide diphosphokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN] +synonym: "ATP nucleotide 3'-pyrophosphokinase activity" RELATED [EC:2.7.6.4] +synonym: "ATP:nucleoside-5'-phosphate diphosphotransferase activity" RELATED [EC:2.7.6.4] +synonym: "ATP:nucleotide pyrophosphotransferase activity" RELATED [EC:2.7.6.4] +synonym: "nucleotide 3'-pyrophosphokinase activity" RELATED [EC:2.7.6.4] +synonym: "nucleotide pyrophosphokinase activity" EXACT [] +xref: EC:2.7.6.4 +xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN +xref: RHEA:12713 +is_a: GO:0016778 ! diphosphotransferase activity + +[Term] +id: GO:0050149 +name: o-aminophenol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN] +synonym: "2-aminophenol:O2 oxidoreductase activity" RELATED [EC:1.10.3.4] +synonym: "2-aminophenol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.4] +synonym: "GriF" RELATED [EC:1.10.3.4] +synonym: "isophenoxazine synthase activity" RELATED [EC:1.10.3.4] +synonym: "o-aminophenol:O2 oxidoreductase activity" RELATED [EC:1.10.3.4] +xref: EC:1.10.3.4 +xref: MetaCyc:O-AMINOPHENOL-OXIDASE-RXN +xref: RHEA:40963 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0050150 +name: o-pyrocatechuate decarboxylase activity +namespace: molecular_function +alt_id: GO:0018790 +def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.46, RHEA:21492] +synonym: "2,3-DHBA decarboxylase activity" RELATED [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)" RELATED [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoate carboxy-lyase activity" RELATED [EC:4.1.1.46] +synonym: "2,3-dihydroxybenzoate decarboxylase activity" EXACT [] +synonym: "2,3-dihydroxybenzoic acid decarboxylase activity" RELATED [EC:4.1.1.46] +xref: EC:4.1.1.46 +xref: KEGG_REACTION:R00821 +xref: MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN +xref: RHEA:21492 +xref: UM-BBD_reactionID:r0579 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050151 +name: oleate hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate." [EC:4.2.1.53, RHEA:21852] +synonym: "(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming)" RELATED [EC:4.2.1.53] +synonym: "(R)-10-hydroxystearate 10-hydro-lyase activity" RELATED [EC:4.2.1.53] +xref: EC:4.2.1.53 +xref: KEGG_REACTION:R02813 +xref: MetaCyc:OLEATE-HYDRATASE-RXN +xref: RHEA:21852 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050152 +name: omega-amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN] +synonym: "alpha-keto acid-omega-amidase activity" RELATED [EC:3.5.1.3] +synonym: "omega-amidodicarboxylate amidohydrolase activity" RELATED [EC:3.5.1.3] +synonym: "w-amidase activity" EXACT [] +xref: EC:3.5.1.3 +xref: MetaCyc:OMEGA-AMIDASE-RXN +xref: RHEA:11716 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050153 +name: omega-hydroxydecanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH." [EC:1.1.1.66, RHEA:20880] +synonym: "10-hydroxydecanoate:NAD+ 10-oxidoreductase activity" RELATED [EC:1.1.1.66] +synonym: "w-hydroxydecanoate dehydrogenase activity" EXACT [] +xref: EC:1.1.1.66 +xref: KEGG_REACTION:R03886 +xref: MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN +xref: RHEA:20880 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050154 +name: opheline kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+)." [EC:2.7.3.7, RHEA:17553] +synonym: "ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity" RELATED [EC:2.7.3.7] +xref: EC:2.7.3.7 +xref: KEGG_REACTION:R04388 +xref: MetaCyc:OPHELINE-KINASE-RXN +xref: RHEA:17553 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050155 +name: ornithine(lysine) transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN] +synonym: "L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity" EXACT [] +synonym: "L-ornithine:2-oxoglutarate-aminotransferase activity" EXACT [] +synonym: "lysine/ornithine:2-oxoglutarate aminotransferase activity" EXACT [] +synonym: "ornithine(lysine) aminotransferase activity" EXACT [] +xref: EC:2.6.1.13 +xref: MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050156 +name: ornithine N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)." [EC:2.3.1.127, RHEA:16929] +synonym: "benzoyl-CoA:L-ornithine N-benzoyltransferase activity" RELATED [EC:2.3.1.127] +synonym: "ornithine N-acyltransferase activity" RELATED [EC:2.3.1.127] +xref: EC:2.3.1.127 +xref: KEGG_REACTION:R00664 +xref: MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN +xref: RHEA:16929 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050157 +name: ornithine racemase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN] +xref: EC:5.1.1.12 +xref: MetaCyc:ORNITHINE-RACEMASE-RXN +xref: RHEA:11584 +is_a: GO:0047661 ! amino-acid racemase activity + +[Term] +id: GO:0050158 +name: orotate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate." [EC:1.3.1.15, RHEA:14861] +synonym: "(S)-dihydroorotate:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.15] +synonym: "dihydro-orotic dehydrogenase activity" RELATED [EC:1.3.1.15] +synonym: "L-5,6-dihydro-orotate:NAD oxidoreductase activity" RELATED [EC:1.3.1.15] +synonym: "orotate reductase activity" RELATED [EC:1.3.1.15] +xref: EC:1.3.1.15 +xref: KEGG_REACTION:R01866 +xref: MetaCyc:OROTATE-REDUCTASE-NADPH-RXN +xref: RHEA:14861 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050159 +name: orsellinate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol." [EC:4.1.1.58, RHEA:16733] +synonym: "orsellinate carboxy-lyase (orcinol-forming)" RELATED [EC:4.1.1.58] +synonym: "orsellinate carboxy-lyase activity" RELATED [EC:4.1.1.58] +xref: EC:4.1.1.58 +xref: KEGG_REACTION:R02831 +xref: MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN +xref: RHEA:16733 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050160 +name: orsellinate-depside hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+)." [EC:3.1.1.40, RHEA:19549] +synonym: "lecanorate hydrolase activity" RELATED [EC:3.1.1.40] +xref: EC:3.1.1.40 +xref: KEGG_REACTION:R00054 +xref: MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN +xref: RHEA:19549 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050161 +name: succinyl-CoA:oxalate CoA-transferase +namespace: molecular_function +def: "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23588] +synonym: "oxalate CoA-transferase activity" RELATED [EC:2.8.3.2] +synonym: "oxalate coenzyme A-transferase activity" RELATED [EC:2.8.3.2] +synonym: "succinyl-beta-ketoacyl-CoA transferase activity" RELATED [EC:2.8.3.2] +synonym: "succinyl-CoA:oxalate CoA-transferase activity" RELATED [EC:2.8.3.2] +xref: EC:2.8.3.2 +xref: KEGG_REACTION:R01559 +xref: MetaCyc:OXALATE-COA-TRANSFERASE-RXN +xref: RHEA:23588 +is_a: GO:0008410 ! CoA-transferase activity + +[Term] +id: GO:0050162 +name: oxalate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2)." [RHEA:21880] +synonym: "aero-oxalo dehydrogenase activity" RELATED [EC:1.2.3.4] +synonym: "oxalate:oxygen oxidoreductase activity" RELATED [EC:1.2.3.4] +synonym: "oxalic acid oxidase activity" RELATED [EC:1.2.3.4] +xref: EC:1.2.3.4 +xref: KEGG_REACTION:R00273 +xref: MetaCyc:OXALATE-OXIDASE-RXN +xref: RHEA:21880 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050163 +name: oxaloacetate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: oxaloacetate = enol-oxaloacetate." [EC:5.3.2.2, RHEA:16021] +synonym: "oxalacetic keto-enol isomerase activity" RELATED [EC:5.3.2.2] +synonym: "oxaloacetate keto-enol tautomerase activity" RELATED [EC:5.3.2.2] +synonym: "oxaloacetate keto-enol-isomerase activity" RELATED [EC:5.3.2.2] +xref: EC:5.3.2.2 +xref: KEGG_REACTION:R00363 +xref: MetaCyc:OXALOACETATE-TAUTOMERASE-RXN +xref: RHEA:16021 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0050164 +name: oxoglutarate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA." [EC:1.2.1.52, RHEA:21400] +synonym: "2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)" RELATED [EC:1.2.1.52] +xref: EC:1.2.1.52 +xref: KEGG_REACTION:R00265 +xref: MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:21400 +is_a: GO:0034601 ! oxoglutarate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0050165 +name: pantetheine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN] +synonym: "ATP:pantetheine 4'-phosphotransferase activity" RELATED [EC:2.7.1.34] +synonym: "pantetheine kinase (phosphorylating)" RELATED [EC:2.7.1.34] +xref: EC:2.7.1.34 +xref: MetaCyc:PANTETHEINE-KINASE-RXN +xref: RHEA:22472 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050166 +name: pantoate 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH." [EC:1.1.1.106, RHEA:23000] +synonym: "(R)-pantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.106] +synonym: "D-pantoate:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.106] +synonym: "panthothenase activity" RELATED [EC:1.1.1.106] +synonym: "pantoate dehydrogenase activity" RELATED [EC:1.1.1.106] +xref: EC:1.1.1.106 +xref: KEGG_REACTION:R02471 +xref: MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN +xref: RHEA:23000 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050167 +name: pantothenoylcysteine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2)." [EC:4.1.1.30, RHEA:15077] +synonym: "N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.30] +synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)" RELATED [EC:4.1.1.30] +synonym: "N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity" RELATED [EC:4.1.1.30] +synonym: "pantothenylcysteine decarboxylase activity" RELATED [EC:4.1.1.30] +xref: EC:4.1.1.30 +xref: KEGG_REACTION:R02972 +xref: MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN +xref: RHEA:15077 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050168 +name: pentanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate." [EC:3.5.1.50, RHEA:10000] +synonym: "pentanamide amidohydrolase activity" RELATED [EC:3.5.1.50] +synonym: "valeramidase activity" RELATED [EC:3.5.1.50] +xref: EC:3.5.1.50 +xref: KEGG_REACTION:R02938 +xref: MetaCyc:PENTANAMIDASE-RXN +xref: RHEA:10000 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050169 +name: peptide-tryptophan 2,3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN, PMID:4403729] +synonym: "peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.26] +synonym: "peptidyltryptophan 2,3-dioxygenase activity" RELATED [EC:1.13.11.26] +synonym: "pyrrolooxygenase activity" RELATED [EC:1.13.11.26] +synonym: "tryptophan pyrrolooxygenase activity" RELATED [EC:1.13.11.26] +xref: EC:1.13.11.26 +xref: MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0050170 +name: peptidyl-glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN] +synonym: "peptideglutaminase activity" RELATED [EC:3.5.1.43] +synonym: "peptidoglutaminase activity" RELATED [EC:3.5.1.43] +synonym: "peptidoglutaminase I activity" NARROW [EC:3.5.1.43] +synonym: "peptidyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.43] +xref: EC:3.5.1.43 +xref: MetaCyc:PEPTIDYL-GLUTAMINASE-RXN +xref: RHEA:10032 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050171 +name: phenol beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN] +synonym: "phenol b-glucosyltransferase activity" EXACT [] +synonym: "phenol-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "UDP glucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "UDP-glucose glucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "UDP-glucose:phenol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "UDPglucose:phenol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "UDPglucosyltransferase activity" RELATED [EC:2.4.1.35] +synonym: "uridine diphosphoglucosyltransferase activity" RELATED [EC:2.4.1.35] +xref: EC:2.4.1.35 +xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050172 +name: phenylalanine 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O." [EC:1.13.12.9, RHEA:10712] +synonym: "L-phenylalanine oxidase (deaminating and decarboxylating)" RELATED [EC:1.13.12.9] +synonym: "l-phenylalanine oxidase (deaminating and decarboxylating) activity" RELATED [EC:1.13.12.9] +synonym: "L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.9] +synonym: "phenylalanine (deaminating, decarboxylating) oxidase activity" RELATED [EC:1.13.12.9] +synonym: "phenylalanine (deaminating, decarboxylating)oxidase activity" RELATED [EC:1.13.12.9] +xref: EC:1.13.12.9 +xref: KEGG_REACTION:R00690 +xref: MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN +xref: RHEA:10712 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050173 +name: phenylalanine adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+)." [EC:2.7.7.54, RHEA:17189] +synonym: "ATP:L-phenylalanine adenylyltransferase activity" RELATED [EC:2.7.7.54] +synonym: "ATP:phenylalanine adenylyltransferase activity" EXACT [] +synonym: "L-phenylalanine adenylyltransferase activity" RELATED [EC:2.7.7.54] +xref: EC:2.7.7.54 +xref: KEGG_REACTION:R00687 +xref: MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN +xref: RHEA:17189 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0050174 +name: phenylalanine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN] +synonym: "aromatic L-amino acid decarboxylase activity" BROAD [] +synonym: "L-phenylalanine carboxy-lyase (phenylethylamine-forming)" EXACT [] +synonym: "L-phenylalanine carboxy-lyase activity" RELATED [EC:4.1.1.53] +synonym: "L-phenylalanine decarboxylase activity" RELATED [EC:4.1.1.53] +xref: EC:4.1.1.53 +xref: MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN +xref: RHEA:19717 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050175 +name: phenylalanine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN] +synonym: "L-phenylalanine dehydrogenase activity" RELATED [EC:1.4.1.20] +synonym: "L-phenylalanine:NAD+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.20] +synonym: "PHD" RELATED [EC:1.4.1.20] +synonym: "PheDH activity" RELATED [EC:1.4.1.20] +xref: EC:1.4.1.20 +xref: MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN +xref: RHEA:21408 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050176 +name: phenylalanine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)." [EC:2.3.1.53, RHEA:17801] +synonym: "acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity" RELATED [EC:2.3.1.53] +synonym: "acetyl-CoA:L-phenylalanine N-acetyltransferase activity" RELATED [EC:2.3.1.53] +xref: EC:2.3.1.53 +xref: KEGG_REACTION:R00693 +xref: MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN +xref: RHEA:17801 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0050177 +name: phenylpyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN] +synonym: "phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)" RELATED [EC:4.1.1.43] +synonym: "phenylpyruvate carboxy-lyase activity" RELATED [EC:4.1.1.43] +xref: EC:4.1.1.43 +xref: MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN +xref: RHEA:14185 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050178 +name: phenylpyruvate tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN] +synonym: "phenylpyruvate keto--enol tautomerase activity" RELATED [EC:5.3.2.1] +synonym: "phenylpyruvate keto-enol-isomerase activity" RELATED [EC:5.3.2.1] +synonym: "phenylpyruvic keto--enol isomerase activity" RELATED [EC:5.3.2.1] +xref: EC:5.3.2.1 +xref: MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN +xref: RHEA:17097 +is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups + +[Term] +id: GO:0050179 +name: phenylserine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21712] +synonym: "L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)" RELATED [EC:4.1.2.26] +synonym: "L-threo-3-phenylserine benzaldehyde-lyase activity" RELATED [EC:4.1.2.26] +xref: EC:4.1.2.26 +xref: KEGG_REACTION:R01766 +xref: MetaCyc:PHENYLSERINE-ALDOLASE-RXN +xref: RHEA:21712 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050180 +name: phloretin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23396] +synonym: "2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity" RELATED [EC:3.7.1.4] +synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.7.1.4] +xref: EC:3.7.1.4 +xref: KEGG_REACTION:R02901 +xref: MetaCyc:PHLORETIN-HYDROLASE-RXN +xref: RHEA:23396 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0050181 +name: phorbol-diester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21316] +synonym: "12,13-diacylphorbate 12-acylhydrolase activity" RELATED [EC:3.1.1.51] +synonym: "diacylphorbate 12-hydrolase activity" RELATED [EC:3.1.1.51] +synonym: "PDEH" RELATED [EC:3.1.1.51] +synonym: "phorbol-12,13-diester 12-ester hydrolase activity" RELATED [EC:3.1.1.51] +xref: EC:3.1.1.51 +xref: KEGG_REACTION:R04119 +xref: MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN +xref: RHEA:21316 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050182 +name: phosphate butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20892] +synonym: "butanoyl-CoA:phosphate butanoyltransferase activity" RELATED [EC:2.3.1.19] +synonym: "phosphotransbutyrylase activity" RELATED [EC:2.3.1.19] +xref: EC:2.3.1.19 +xref: KEGG_REACTION:R01174 +xref: MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN +xref: RHEA:20892 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050183 +name: phosphatidylcholine 12-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+)." [RHEA:46360] +synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating)" RELATED [EC:1.14.18.4] +synonym: "oleate D12-hydroxylase activity" EXACT [] +synonym: "oleate Delta(12)-hydroxylase activity" RELATED [EC:1.14.18.4] +synonym: "oleate delta12-hydroxylase activity" RELATED [EC:1.14.18.4] +synonym: "oleate delta12-monooxygenase activity" RELATED [EC:1.14.18.4] +synonym: "ricinoleic acid synthase activity" RELATED [EC:1.14.18.4] +xref: EC:1.14.18.4 +xref: KEGG_REACTION:R03476 +xref: MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN +xref: RHEA:46360 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050184 +name: phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." [RHEA:12564] +synonym: "1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity" RELATED [] +synonym: "acyl-lipid omega-6 desaturase (cytochrome b5)" RELATED [EC:1.14.19.22] +synonym: "linoleate synthase activity" RELATED [EC:1.14.19.22] +synonym: "oleate desaturase activity" RELATED [EC:1.14.19.22] +synonym: "oleoyl-CoA desaturase activity" RELATED [EC:1.14.19.22] +synonym: "oleoylphosphatidylcholine desaturase activity" RELATED [] +xref: EC:1.14.19.22 +xref: KEGG_REACTION:R03475 +xref: MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN +xref: RHEA:12564 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050185 +name: phosphatidylinositol deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [EC:3.1.1.52, RHEA:18001] +synonym: "1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity" RELATED [EC:3.1.1.52] +synonym: "phosphatidylinositol phospholipase A2 activity" RELATED [EC:3.1.1.52] +xref: EC:3.1.1.52 +xref: KEGG_REACTION:R03360 +xref: MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN +xref: RHEA:18001 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050186 +name: phosphoadenylylsulfatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN] +synonym: "3'-phosphoadenylylsulfate sulfohydrolase activity" RELATED [EC:3.6.2.2] +synonym: "3-phosphoadenosine 5-phosphosulfate sulfatase activity" RELATED [EC:3.6.2.2] +synonym: "3-phosphoadenylyl sulfatase activity" RELATED [EC:3.6.2.2] +synonym: "PAPS sulfatase activity" RELATED [EC:3.6.2.2] +synonym: "phosphoadenylylsulphatase activity" EXACT [] +xref: EC:3.6.2.2 +xref: MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN +xref: RHEA:11232 +is_a: GO:0016819 ! hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides + +[Term] +id: GO:0050187 +name: phosphoamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate." [EC:3.9.1.1, RHEA:12977] +synonym: "creatine phosphatase activity" RELATED [EC:3.9.1.1] +synonym: "phosphamide hydrolase activity" RELATED [EC:3.9.1.1] +xref: EC:3.9.1.1 +xref: KEGG_REACTION:R01882 +xref: MetaCyc:PHOSPHOAMIDASE-RXN +xref: RHEA:12977 +is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds + +[Term] +id: GO:0050188 +name: phosphoenolpyruvate mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate." [EC:5.4.2.9, RHEA:17013] +synonym: "PEP mutase activity" RELATED [EC:5.4.2.9] +synonym: "PEP phosphomutase activity" RELATED [EC:5.4.2.9] +synonym: "PEPPM" RELATED [EC:5.4.2.9] +synonym: "phosphoenolpyruvate 2,3-phosphonomutase activity" RELATED [EC:5.4.2.9] +synonym: "phosphoenolpyruvate phosphomutase activity" RELATED [EC:5.4.2.9] +synonym: "phosphoenolpyruvate-phosphonopyruvate phosphomutase activity" RELATED [EC:5.4.2.9] +xref: EC:5.4.2.9 +xref: KEGG_REACTION:R00661 +xref: MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN +xref: RHEA:17013 +is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases + +[Term] +id: GO:0050189 +name: phosphoenolpyruvate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:19997] +synonym: "PEP phosphatase activity" RELATED [EC:3.1.3.60] +synonym: "phosphoenolpyruvate phosphohydrolase activity" RELATED [EC:3.1.3.60] +xref: EC:3.1.3.60 +xref: KEGG_REACTION:R00208 +xref: MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN +xref: RHEA:19997 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050190 +name: phosphoglucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.10, RHEA:13377] +synonym: "ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.10] +synonym: "ATP:D-glucose-1-phosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.10] +synonym: "glucose-phosphate kinase activity" RELATED [EC:2.7.1.10] +synonym: "phosphoglucokinase (phosphorylating)" RELATED [EC:2.7.1.10] +xref: EC:2.7.1.10 +xref: KEGG_REACTION:R00949 +xref: MetaCyc:PHOSPHOGLUCOKINASE-RXN +xref: RHEA:13377 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050191 +name: phosphoglycerate kinase (GTP) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+)." [EC:2.7.2.10, RHEA:23332] +synonym: "GTP:3-phospho-D-glycerate 1-phosphotransferase activity" RELATED [EC:2.7.2.10] +xref: EC:2.7.2.10 +xref: KEGG_REACTION:R01517 +xref: MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN +xref: RHEA:23332 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor + +[Term] +id: GO:0050192 +name: phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21156] +synonym: "D-2-phosphoglycerate phosphatase activity" RELATED [EC:3.1.3.20] +synonym: "D-glycerate-2-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.20] +synonym: "glycerophosphate phosphatase activity" RELATED [EC:3.1.3.20] +xref: EC:3.1.3.20 +xref: KEGG_REACTION:R01748 +xref: MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN +xref: RHEA:21156 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050193 +name: phosphoketolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN] +synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)" RELATED [EC:4.1.2.9] +synonym: "D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity" RELATED [EC:4.1.2.9] +synonym: "xylulose-5-phosphate phosphoketolase activity" RELATED [EC:4.1.2.9] +xref: EC:4.1.2.9 +xref: MetaCyc:PHOSPHOKETOLASE-RXN +xref: RHEA:10468 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050194 +name: phosphonoacetaldehyde hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate." [EC:3.11.1.1, RHEA:18905] +synonym: "2-oxoethylphosphonate phosphonohydrolase activity" RELATED [EC:3.11.1.1] +synonym: "2-phosphonoacetylaldehyde phosphonohydrolase activity" RELATED [EC:3.11.1.1] +synonym: "phosphonatase activity" RELATED [EC:3.11.1.1] +synonym: "phosphonoacetylaldehyde phosphonohydrolase activity" RELATED [EC:3.11.1.1] +xref: EC:3.11.1.1 +xref: KEGG_REACTION:R00747 +xref: MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN +xref: RHEA:18905 +is_a: GO:0016827 ! hydrolase activity, acting on acid carbon-phosphorus bonds + +[Term] +id: GO:0050195 +name: phosphoribokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+)." [EC:2.7.1.18, RHEA:21216] +synonym: "ATP:D-ribose-5-phosphate 1-phosphotransferase activity" RELATED [EC:2.7.1.18] +synonym: "phosphoribokinase (phosphorylating)" RELATED [EC:2.7.1.18] +xref: EC:2.7.1.18 +xref: KEGG_REACTION:R01050 +xref: MetaCyc:PHOSPHORIBOKINASE-RXN +xref: RHEA:21216 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050196 +name: [phosphorylase] phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN] +synonym: "glycogen phosphorylase phosphatase activity" RELATED [EC:3.1.3.17] +synonym: "phosphorylase a phosphatase activity" RELATED [EC:3.1.3.17] +synonym: "phosphorylase a phosphohydrolase activity" RELATED [EC:3.1.3.17] +synonym: "phosphorylase phosphatase activity" EXACT [] +synonym: "PR-enzyme" RELATED [EC:3.1.3.17] +synonym: "protein phosphatase C" RELATED [EC:3.1.3.17] +synonym: "type 1 protein phosphatase activity" RELATED [EC:3.1.3.17] +xref: EC:3.1.3.17 +xref: MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0050197 +name: phytanate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21380] +synonym: "phytanate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.24] +synonym: "phytanoyl-CoA ligase activity" RELATED [EC:6.2.1.24] +xref: EC:6.2.1.24 +xref: KEGG_REACTION:R03631 +xref: MetaCyc:PHYTANATE--COA-LIGASE-RXN +xref: Reactome:R-HSA-389622 "phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate" +xref: RHEA:21380 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050198 +name: pinosylvin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12552] +synonym: "malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.146] +synonym: "pine stilbene synthase activity" RELATED [EC:2.3.1.146] +synonym: "stilbene synthase activity" BROAD [EC:2.3.1.146] +xref: EC:2.3.1.146 +xref: KEGG_REACTION:R02505 +xref: MetaCyc:PINOSYLVIN-SYNTHASE-RXN +xref: RHEA:12552 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050199 +name: piperidine N-piperoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+)." [EC:2.3.1.145, RHEA:14561] +synonym: "(E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity" RELATED [EC:2.3.1.145] +synonym: "piperidine piperoyltransferase activity" RELATED [EC:2.3.1.145] +synonym: "piperoyl-CoA:piperidine N-piperoyltransferase activity" RELATED [EC:2.3.1.145] +xref: EC:2.3.1.145 +xref: KEGG_REACTION:R03994 +xref: MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN +xref: RHEA:14561 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050200 +name: plasmalogen synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN] +synonym: "1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity" RELATED [EC:2.3.1.25] +synonym: "acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity" RELATED [EC:2.3.1.25] +synonym: "lysoplasmenylcholine acyltransferase activity" RELATED [EC:2.3.1.25] +synonym: "O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity" RELATED [EC:2.3.1.25] +xref: EC:2.3.1.25 +xref: MetaCyc:PLASMALOGEN-SYNTHASE-RXN +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050201 +name: fucokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.52, RHEA:13241] +synonym: "ATP:6-deoxy-L-galactose 1-phosphotransferase activity" RELATED [EC:2.7.1.52] +synonym: "ATP:beta-L-fucose 1-phosphotransferase activity" RELATED [EC:2.7.1.52] +synonym: "fucokinase (phosphorylating) activity" RELATED [EC:2.7.1.52] +synonym: "fucose kinase activity" RELATED [EC:2.7.1.52] +synonym: "L-fucokinase activity" RELATED [EC:2.7.1.52] +synonym: "L-fucose kinase activity" RELATED [EC:2.7.1.52] +xref: EC:2.7.1.52 +xref: KEGG_REACTION:R03161 +xref: MetaCyc:FUCOKINASE-RXN +xref: Reactome:R-HSA-6787540 "FUK phosphorylates beta-Fuc to Fuc1P" +xref: RHEA:13241 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050202 +name: octopamine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+)." [EC:4.2.1.87, RHEA:18173] +synonym: "octopamine hydro-lyase (deaminating)" RELATED [EC:4.2.1.87] +synonym: "octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming]" RELATED [EC:4.2.1.87] +synonym: "octopamine hydrolyase activity" RELATED [EC:4.2.1.87] +xref: EC:4.2.1.87 +xref: KEGG_REACTION:R03358 +xref: MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN +xref: RHEA:18173 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050203 +name: oxalate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." [RHEA:18293] +synonym: "oxalate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.8] +synonym: "oxalyl coenzyme A synthetase activity" RELATED [EC:6.2.1.8] +synonym: "oxalyl-CoA synthetase activity" RELATED [EC:6.2.1.8] +xref: EC:6.2.1.8 +xref: KEGG_REACTION:R01558 +xref: MetaCyc:OXALATE--COA-LIGASE-RXN +xref: RHEA:18293 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050204 +name: oxalomalate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate." [EC:4.1.3.13, RHEA:22032] +synonym: "3-oxalomalate glyoxylate-lyase (oxaloacetate-forming)" RELATED [EC:4.1.3.13] +synonym: "3-oxalomalate glyoxylate-lyase activity" RELATED [EC:4.1.3.13] +xref: EC:4.1.3.13 +xref: KEGG_REACTION:R00477 +xref: MetaCyc:OXALOMALATE-LYASE-RXN +xref: RHEA:22032 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0050205 +name: oxamate carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22984] +synonym: "carbamoyl-phosphate:oxamate carbamoyltransferase activity" RELATED [EC:2.1.3.5] +synonym: "oxamic transcarbamylase activity" RELATED [EC:2.1.3.5] +xref: EC:2.1.3.5 +xref: KEGG_REACTION:R02937 +xref: MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN +xref: RHEA:22984 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050206 +name: oximinotransferase activity +namespace: molecular_function +alt_id: GO:0016770 +def: "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [RHEA:11624] +synonym: "oximase activity" RELATED [EC:2.6.3.1] +synonym: "oximinotransaminase activity" RELATED [] +synonym: "pyruvate-acetone oximinotransferase activity" RELATED [EC:2.6.3.1] +synonym: "transoximase activity" RELATED [EC:2.6.3.1] +synonym: "transoximinase activity" RELATED [EC:2.6.3.1] +xref: EC:2.6.3.1 +xref: KEGG_REACTION:R03796 +xref: MetaCyc:OXIMINOTRANSFERASE-RXN +xref: RHEA:11624 +is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups + +[Term] +id: GO:0050207 +name: plasmanylethanolamine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [RHEA:22956] +synonym: "1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" RELATED [EC:1.14.99.19] +synonym: "1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity" RELATED [EC:1.14.99.19] +synonym: "alkylacylglycero-phosphorylethanolamine dehydrogenase activity" RELATED [EC:1.14.99.19] +synonym: "alkylacylglycerophosphoethanolamine desaturase activity" RELATED [EC:1.14.99.19] +synonym: "dehydrogenase, alkyl-acylglycerophosphorylethanolamine" RELATED [EC:1.14.99.19] +synonym: "O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.99.19] +synonym: "plasmenylethanolamine desaturase activity" EXACT [] +xref: EC:1.14.19.77 +xref: MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN +xref: RHEA:22956 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050208 +name: polysialic-acid O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN] +synonym: "acetyl-CoA:polysialic-acid O-acetyltransferase activity" EXACT [] +xref: EC:2.3.1.136 +xref: MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN +xref: RHEA:11604 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050209 +name: polyvinyl-alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN] +synonym: "dehydrogenase, polyvinyl alcohol" RELATED [EC:1.1.3.30] +synonym: "polyvinyl-alcohol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.30] +synonym: "PVA oxidase activity" RELATED [EC:1.1.3.30] +xref: EC:1.1.3.30 +xref: MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN +xref: RHEA:21688 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050210 +name: prenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN] +synonym: "prenol pyrophosphatase activity" RELATED [EC:3.1.7.1] +synonym: "prenyl-diphosphate diphosphohydrolase activity" RELATED [EC:3.1.7.1] +synonym: "prenyl-pyrophosphatase activity" EXACT [] +synonym: "prenylphosphatase activity" RELATED [EC:3.1.7.1] +xref: EC:3.1.7.1 +xref: MetaCyc:PRENYL-PYROPHOSPHATASE-RXN +xref: RHEA:21496 +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0050211 +name: procollagen galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN] +synonym: "collagen galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "collagen hydroxylysyl galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "hydroxylysine galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "UDP galactose-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity" RELATED [EC:2.4.1.50] +synonym: "uridine diphosphogalactose-collagen galactosyltransferase activity" RELATED [EC:2.4.1.50] +xref: EC:2.4.1.50 +xref: MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN +xref: Reactome:R-HSA-1981120 "Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2." +xref: Reactome:R-HSA-1981128 "Galactosylation of collagen propeptide hydroxylysines by PLOD3" +xref: RHEA:12637 +is_a: GO:0035250 ! UDP-galactosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0050212 +name: progesterone 11-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O." [EC:1.14.99.14, RHEA:18205] +synonym: "progesterone 11-alpha-hydroxylase activity" RELATED [EC:1.14.99.14] +synonym: "progesterone 11a-monooxygenase activity" EXACT [] +synonym: "progesterone 11alpha-hydroxylase activity" RELATED [EC:1.14.99.14] +synonym: "progesterone 11alpha-monooxygenase activity" RELATED [EC:1.14.99.14] +synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)" RELATED [EC:1.14.99.14] +xref: EC:1.14.99.14 +xref: KEGG_REACTION:R02214 +xref: MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN +xref: RHEA:18205 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050213 +name: progesterone 5-alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN] +synonym: "5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity" RELATED [EC:1.3.1.30] +synonym: "delta4-steroid 5alpha-reductase (progesterone)" RELATED [EC:1.3.1.30] +synonym: "progesterone 5a-reductase activity" EXACT [] +synonym: "progesterone 5alpha-reductase activity" RELATED [EC:1.3.1.30] +synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.1.30] +xref: EC:1.3.1.30 +xref: MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN +xref: RHEA:21952 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050214 +name: progesterone monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate." [EC:1.14.99.4, RHEA:11984] +synonym: "progesterone hydroxylase activity" RELATED [EC:1.14.99.4] +synonym: "progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" RELATED [EC:1.14.99.4] +xref: EC:1.14.99.4 +xref: KEGG_REACTION:R02212 +xref: MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN +xref: RHEA:11984 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050215 +name: propanediol dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal." [EC:4.2.1.28, RHEA:14569] +synonym: "1,2-propanediol dehydratase activity" RELATED [EC:4.2.1.28] +synonym: "adenosylcobalamin-dependent diol dehydratase activity" RELATED [EC:4.2.1.28] +synonym: "coenzyme B12-dependent diol dehydrase activity" RELATED [EC:4.2.1.28] +synonym: "diol dehydrase activity" RELATED [EC:4.2.1.28] +synonym: "diol dehydratase activity" RELATED [EC:4.2.1.28] +synonym: "dioldehydratase activity" RELATED [EC:4.2.1.28] +synonym: "DL-1,2-propanediol hydro-lyase activity" RELATED [EC:4.2.1.28] +synonym: "meso-2,3-butanediol dehydrase activity" RELATED [EC:4.2.1.28] +synonym: "propane-1,2-diol hydro-lyase (propanal-forming)" RELATED [EC:4.2.1.28] +synonym: "propane-1,2-diol hydro-lyase activity" RELATED [EC:4.2.1.28] +synonym: "propanediol dehydrase activity" RELATED [EC:4.2.1.28] +xref: EC:4.2.1.28 +xref: KEGG_REACTION:R02376 +xref: MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN +xref: RHEA:14569 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050216 +name: propanediol-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21584] +xref: EC:1.1.1.7 +xref: KEGG_REACTION:R04236 +xref: MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN +xref: RHEA:21584 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050217 +name: propioin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal." [EC:4.1.2.35, RHEA:11100] +synonym: "4-hydroxy-3-hexanone aldolase activity" RELATED [EC:4.1.2.35] +synonym: "4-hydroxy-3-hexanone propanal-lyase (propanal-forming)" RELATED [EC:4.1.2.35] +synonym: "4-hydroxy-3-hexanone propanal-lyase activity" RELATED [EC:4.1.2.35] +xref: EC:4.1.2.35 +xref: KEGG_REACTION:R00038 +xref: MetaCyc:PROPIOIN-SYNTHASE-RXN +xref: RHEA:11100 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050218 +name: propionate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN] +synonym: "propanoate:CoA ligase (AMP-forming)" RELATED [EC:6.2.1.17] +synonym: "propionyl-CoA synthetase activity" RELATED [EC:6.2.1.17] +xref: EC:6.2.1.17 +xref: MetaCyc:PROPIONATE--COA-LIGASE-RXN +xref: RHEA:20373 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0050219 +name: prostaglandin-A1 delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin A1 = prostaglandin C1." [EC:5.3.3.9, RHEA:10460] +synonym: "(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity" RELATED [EC:5.3.3.9] +synonym: "prostaglandin A isomerase activity" RELATED [EC:5.3.3.9] +synonym: "prostaglandin-A1 D-isomerase activity" EXACT [] +xref: EC:5.3.3.9 +xref: KEGG_REACTION:R04565 +xref: MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN +xref: RHEA:10460 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050220 +name: prostaglandin-E synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2)." [EC:5.3.99.3, RHEA:12893] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" RELATED [EC:5.3.99.3] +synonym: "endoperoxide isomerase activity" RELATED [EC:5.3.99.3] +synonym: "PGE isomerase activity" RELATED [EC:5.3.99.3] +synonym: "PGE2 isomerase activity" RELATED [EC:5.3.99.3] +synonym: "PGH-PGE isomerase activity" RELATED [EC:5.3.99.3] +synonym: "prostaglandin endoperoxide E isomerase activity" RELATED [EC:5.3.99.3] +synonym: "prostaglandin endoperoxide E2 isomerase activity" RELATED [EC:5.3.99.3] +synonym: "prostaglandin H-E isomerase activity" RELATED [EC:5.3.99.3] +synonym: "prostaglandin R-prostaglandin E isomerase activity" RELATED [EC:5.3.99.3] +synonym: "Prostaglandin-H(2) E-isomerase activity" RELATED [EC:5.3.99.3] +synonym: "prostaglandin-H2 E-isomerase activity" RELATED [EC:5.3.99.3] +xref: EC:5.3.99.3 +xref: KEGG_REACTION:R02265 +xref: MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN +xref: Reactome:R-HSA-2161660 "PGH2 is isomerised to PGE2 by PTGES" +xref: Reactome:R-HSA-265295 "Prostaglandin E synthase isomerizes PGH2 to PGE2" +xref: RHEA:12893 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0050221 +name: prostaglandin-E2 9-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN] +synonym: "(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity" RELATED [EC:1.1.1.189] +synonym: "9-keto-prostaglandin E(2) reductase activity" RELATED [EC:1.1.1.189] +synonym: "9-keto-prostaglandin E2 reductase activity" RELATED [EC:1.1.1.189] +synonym: "9-ketoprostaglandin reductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE(2) 9-ketoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE(2) 9-oxoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE-9-ketoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE2 9-ketoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE2 9-oxoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE2-9-ketoreductase activity" RELATED [EC:1.1.1.189] +synonym: "PGE2-9-OR" RELATED [EC:1.1.1.189] +synonym: "prostaglandin E 9-ketoreductase activity" RELATED [EC:1.1.1.189] +synonym: "prostaglandin E2-9-oxoreductase activity" RELATED [EC:1.1.1.189] +synonym: "prostaglandin-E(2) 9-oxoreductase activity" RELATED [EC:1.1.1.189] +synonym: "prostaglandin-E2 9-oxoreductase activity" RELATED [EC:1.1.1.189] +synonym: "reductase, 15-hydroxy-9-oxoprostaglandin" RELATED [EC:1.1.1.189] +xref: EC:1.1.1.189 +xref: MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN +xref: Reactome:R-HSA-2161651 "PGE2 is converted to PGF2a by CBR1" +xref: RHEA:24508 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050223 +name: protocatechuate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.63, RHEA:22416] +synonym: "3,4-dihydrobenzoate decarboxylase activity" RELATED [EC:4.1.1.63] +synonym: "3,4-dihydroxybenzoate carboxy-lyase (catechol-forming)" RELATED [EC:4.1.1.63] +synonym: "3,4-dihydroxybenzoate decarboxylase activity" RELATED [EC:4.1.1.63] +synonym: "protocatechuate carboxy-lyase activity" RELATED [EC:4.1.1.63] +xref: EC:4.1.1.63 +xref: KEGG_REACTION:R00822 +xref: MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN +xref: RHEA:22416 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050224 +name: prunasin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16489] +synonym: "prunasin b-glucosidase activity" EXACT [] +synonym: "prunasin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.118] +synonym: "prunasin hydrolase activity" RELATED [EC:3.2.1.118] +xref: EC:3.2.1.118 +xref: KEGG_REACTION:R02558 +xref: MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN +xref: RHEA:16489 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0050225 +name: pseudouridine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22448] +synonym: "ATP:pseudouridine 5'-phosphotransferase activity" RELATED [EC:2.7.1.83] +synonym: "pseudouridine kinase (phosphorylating)" RELATED [EC:2.7.1.83] +xref: EC:2.7.1.83 +xref: KEGG_REACTION:R03315 +xref: MetaCyc:PSEUDOURIDINE-KINASE-RXN +xref: RHEA:22448 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050226 +name: psychosine sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN] +synonym: "3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity" RELATED [EC:2.8.2.13] +synonym: "3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity" RELATED [EC:2.8.2.13] +synonym: "PAPS:psychosine sulphotransferase activity" RELATED [EC:2.8.2.13] +synonym: "psychosine sulphotransferase activity" EXACT [] +xref: EC:2.8.2.13 +xref: MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN +xref: RHEA:14137 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050227 +name: pteridine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN] +synonym: "2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)" RELATED [EC:1.17.3.1] +xref: EC:1.17.3.1 +xref: MetaCyc:PTERIDINE-OXIDASE-RXN +xref: RHEA:12777 +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0050228 +name: pterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN] +synonym: "2-amino-4-hydroxypteridine aminohydrolase activity" RELATED [EC:3.5.4.11] +synonym: "acrasinase activity" RELATED [EC:3.5.4.11] +xref: EC:3.5.4.11 +xref: MetaCyc:PTERIN-DEAMINASE-RXN +xref: RHEA:11904 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050229 +name: pterocarpin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN] +synonym: "medicarpin:NADP+ 2'-oxidoreductase activity" RELATED [EC:1.1.1.246] +synonym: "pterocarpan synthase activity" RELATED [EC:1.1.1.246] +xref: EC:1.1.1.246 +xref: MetaCyc:PTEROCARPIN-SYNTHASE-RXN +xref: RHEA:13533 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050230 +name: purine imidazole-ring cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)" RELATED [EC:4.3.2.4] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming)" RELATED [EC:4.3.2.4] +synonym: "DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)" RELATED [EC:4.3.2.4] +xref: EC:4.3.2.4 +xref: MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN +is_a: GO:0009975 ! cyclase activity +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0050231 +name: putrescine carbamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate." [EC:2.1.3.6, RHEA:21936] +synonym: "carbamoyl-phosphate:putrescine carbamoyltransferase activity" RELATED [EC:2.1.3.6] +synonym: "PTCase activity" RELATED [EC:2.1.3.6] +synonym: "putrescine synthase activity" RELATED [EC:2.1.3.6] +synonym: "putrescine transcarbamylase activity" RELATED [EC:2.1.3.6] +xref: EC:2.1.3.6 +xref: KEGG_REACTION:R01399 +xref: MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN +xref: RHEA:21936 +is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity + +[Term] +id: GO:0050232 +name: putrescine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN] +synonym: "putrescine:oxygen oxidoreductase (deaminating)" RELATED [EC:1.4.3.10] +xref: EC:1.4.3.10 +xref: MetaCyc:PUTRESCINE-OXIDASE-RXN +xref: RHEA:18273 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0050233 +name: pyranose oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2)." [EC:1.1.3.10, RHEA:10552] +synonym: "glucose 2-oxidase activity" RELATED [EC:1.1.3.10] +synonym: "pyranose-2-oxidase activity" RELATED [EC:1.1.3.10] +synonym: "pyranose:oxygen 2-oxidoreductase activity" RELATED [EC:1.1.3.10] +xref: EC:1.1.3.10 +xref: KEGG_REACTION:R00302 +xref: MetaCyc:PYRANOSE-OXIDASE-RXN +xref: RHEA:10552 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050234 +name: pyrazolylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O." [EC:4.2.1.50, RHEA:24512] +synonym: "beta-pyrazolylalaninase activity" RELATED [EC:4.2.1.50] +synonym: "L-serine hydro-lyase (adding pyrazole)" RELATED [EC:4.2.1.50] +synonym: "L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]" RELATED [EC:4.2.1.50] +xref: EC:4.2.1.50 +xref: KEGG_REACTION:R02378 +xref: MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN +xref: RHEA:24512 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050235 +name: pyridoxal 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH." [EC:1.1.1.107, RHEA:21336] +synonym: "pyridoxal dehydrogenase activity" RELATED [EC:1.1.1.107] +synonym: "pyridoxal:NAD+ 4-oxidoreductase activity" RELATED [EC:1.1.1.107] +xref: EC:1.1.1.107 +xref: KEGG_REACTION:R01707 +xref: MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN +xref: RHEA:21336 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050236 +name: pyridoxine:NADP 4-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16129] +synonym: "PL reductase activity" RELATED [EC:1.1.1.65] +synonym: "pyridoxal reductase activity" RELATED [EC:1.1.1.65] +synonym: "pyridoxin dehydrogenase activity" RELATED [EC:1.1.1.65] +synonym: "pyridoxine dehydrogenase activity" RELATED [EC:1.1.1.65] +synonym: "pyridoxine:NADP 4-oxidoreductase activity" RELATED [EC:1.1.1.65] +synonym: "pyridoxol dehydrogenase activity" RELATED [EC:1.1.1.65] +xref: EC:1.1.1.65 +xref: KEGG_REACTION:R01708 +xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN +xref: RHEA:16129 +is_a: GO:0004033 ! aldo-keto reductase (NADP) activity + +[Term] +id: GO:0050237 +name: pyridoxine 4-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN] +synonym: "pyridoxin 4-oxidase activity" RELATED [EC:1.1.3.12] +synonym: "pyridoxine:oxygen 4-oxidoreductase activity" RELATED [EC:1.1.3.12] +synonym: "pyridoxol 4-oxidase activity" RELATED [EC:1.1.3.12] +xref: EC:1.1.3.12 +xref: MetaCyc:PYRIDOXINE-4-OXIDASE-RXN +xref: RHEA:15033 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050238 +name: pyridoxine 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN] +synonym: "pyridoxal-5-dehydrogenase activity" RELATED [EC:1.1.99.9] +synonym: "pyridoxin 5-dehydrogenase activity" RELATED [EC:1.1.99.9] +synonym: "pyridoxine 5'-dehydrogenase activity" RELATED [EC:1.1.99.9] +synonym: "pyridoxine:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.9] +synonym: "pyridoxine:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.9] +synonym: "pyridoxol 5-dehydrogenase activity" RELATED [EC:1.1.99.9] +xref: EC:1.1.99.9 +xref: MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN +xref: RHEA:14497 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050239 +name: pyrithiamine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN] +synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity" RELATED [EC:3.5.4.20] +xref: EC:3.5.4.20 +xref: MetaCyc:PYRITHIAMIN-DEAMINASE-RXN +xref: RHEA:14537 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050240 +name: pyrogallol 1,2-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." [EC:1.13.11.35, RHEA:19673] +synonym: "1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)" RELATED [EC:1.13.11.35] +synonym: "pyrogallol 1,2-dioxygenase activity" RELATED [EC:1.13.11.35] +xref: EC:1.13.11.35 +xref: KEGG_REACTION:R03246 +xref: MetaCyc:PYROGALLOL-12-OXYGENASE-RXN +xref: RHEA:19673 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050241 +name: pyrroline-2-carboxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN] +synonym: "delta1-pyrroline-2-carboxylate reductase activity" RELATED [EC:1.5.1.1] +synonym: "L-proline:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.5.1.1] +xref: EC:1.5.1.1 +xref: MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050242 +name: pyruvate, phosphate dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate." [EC:2.7.9.1, RHEA:10756] +synonym: "ATP:pyruvate, phosphate phosphotransferase activity" RELATED [EC:2.7.9.1] +synonym: "orthophosphate dikinase pyruvate" RELATED [EC:2.7.9.1] +synonym: "PPDK" RELATED [EC:2.7.9.1] +synonym: "pyruvate, Pi dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvate,orthophosphate dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvate,phosphate dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvate-inorganic phosphate dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvate-phosphate dikinase (phosphorylating)" RELATED [EC:2.7.9.1] +synonym: "pyruvate-phosphate dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvate-phosphate ligase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvic-phosphate dikinase activity" RELATED [EC:2.7.9.1] +synonym: "pyruvic-phosphate ligase activity" RELATED [EC:2.7.9.1] +xref: EC:2.7.9.1 +xref: KEGG_REACTION:R00206 +xref: MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN +xref: RHEA:10756 +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0050243 +name: pyruvate dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH." [EC:1.2.1.51, RHEA:17425] +synonym: "pyruvate:NADP(+) oxidoreductase activity" RELATED [EC:1.2.1.51] +synonym: "pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.1.51] +synonym: "pyruvate:NADP+ oxidoreductase activity" RELATED [EC:1.2.1.51] +xref: EC:1.2.1.51 +xref: KEGG_REACTION:R00210 +xref: MetaCyc:PYRUVATE-DEHYDROGENASE-NADP%2b-RXN +xref: RHEA:17425 +is_a: GO:0034603 ! pyruvate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0050244 +name: pyruvate oxidase (CoA-acetylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2)." [EC:1.2.3.6, RHEA:21912] +synonym: "pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)" RELATED [EC:1.2.3.6] +xref: EC:1.2.3.6 +xref: KEGG_REACTION:R00211 +xref: MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN +xref: RHEA:21912 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050245 +name: quercitrinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin." [EC:3.2.1.66, RHEA:17465] +synonym: "quercitrin 3-L-rhamnohydrolase activity" RELATED [EC:3.2.1.66] +xref: EC:3.2.1.66 +xref: KEGG_REACTION:R02436 +xref: MetaCyc:QUERCITRINASE-RXN +xref: RHEA:17465 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050246 +name: questin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+)." [EC:1.14.13.43, RHEA:10836] +synonym: "questin oxygenase activity" RELATED [EC:1.14.13.43] +synonym: "questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)" RELATED [EC:1.14.13.43] +xref: EC:1.14.13.43 +xref: KEGG_REACTION:R02417 +xref: MetaCyc:QUESTIN-MONOOXYGENASE-RXN +xref: RHEA:10836 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050247 +name: raucaffricine beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14557] +synonym: "raucaffricine b-glucosidase activity" EXACT [] +synonym: "raucaffricine beta-D-glucohydrolase activity" RELATED [EC:3.2.1.125] +synonym: "raucaffricine beta-D-glucosidase activity" RELATED [EC:3.2.1.125] +synonym: "raucaffricine glucosidase activity" RELATED [EC:3.2.1.125] +xref: EC:3.2.1.125 +xref: KEGG_REACTION:R03703 +xref: MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN +xref: RHEA:14557 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0050248 +name: Renilla-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "aequorin activity" NARROW [EC:1.13.12.5] +synonym: "luciferase (Renilla luciferin)" RELATED [EC:1.13.12.5] +synonym: "luciferase activity" BROAD [EC:1.13.12.5] +synonym: "Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.5] +synonym: "Renilla-type luciferase activity" RELATED [EC:1.13.12.5] +xref: EC:1.13.12.5 +xref: MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN +xref: RHEA:14765 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0050249 +name: Renilla-luciferin sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate." [EC:2.8.2.10, RHEA:20481] +synonym: "3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity" RELATED [EC:2.8.2.10] +synonym: "luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)" RELATED [EC:2.8.2.10] +synonym: "luciferin sulfokinase activity" RELATED [EC:2.8.2.10] +synonym: "luciferin sulfotransferase activity" BROAD [EC:2.8.2.10] +synonym: "Renilla-luciferin sulphotransferase activity" EXACT [] +xref: EC:2.8.2.10 +xref: KEGG_REACTION:R03138 +xref: MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN +xref: RHEA:20481 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050250 +name: retinal oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN] +synonym: "retinal:oxygen oxidoreductase activity" RELATED [EC:1.2.3.11] +synonym: "retinene oxidase activity" RELATED [EC:1.2.3.11] +xref: EC:1.2.3.11 +xref: MetaCyc:RETINAL-OXIDASE-RXN +xref: RHEA:22520 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0050251 +name: retinol isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinol = 11-cis-retinol." [GOC:pde, RHEA:19141] +synonym: "all-trans-retinol 11-cis-trans-isomerase activity" EXACT [] +synonym: "all-trans-retinol isomerase activity" EXACT [] +xref: KEGG_REACTION:R02369 +xref: MetaCyc:RETINOL-ISOMERASE-RXN +xref: Reactome:R-HSA-2465926 "An atROL isomerase isomerises atROL to 11cROL" +xref: RHEA:19141 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0050252 +name: retinol O-fatty-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN] +synonym: "acyl-CoA:retinol O-acyltransferase activity" RELATED [EC:2.3.1.76] +synonym: "retinol acyltransferase activity" RELATED [EC:2.3.1.76] +synonym: "retinol fatty-acyltransferase activity" RELATED [EC:2.3.1.76] +xref: EC:2.3.1.76 +xref: MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-2465919 "AWAT2 transfers PALM to 11cROL forming 11cRPALM" +xref: Reactome:R-HSA-8848585 "AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM" +xref: RHEA:11488 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0050253 +name: retinyl-palmitate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+." [RHEA:21508] +synonym: "retinyl ester hydrolase activity" RELATED [EC:3.1.1.21] +synonym: "retinyl palmitate hydrolase activity" RELATED [EC:3.1.1.21] +synonym: "retinyl palmitate hydrolyase activity" RELATED [EC:3.1.1.21] +synonym: "retinyl-palmitate palmitohydrolase activity" RELATED [EC:3.1.1.21] +xref: EC:3.1.1.21 +xref: KEGG_REACTION:R02368 +xref: MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN +xref: Reactome:R-HSA-2404133 "A REH hydrolses atREs to atROL and FAs" +xref: Reactome:R-HSA-8848355 "PNPLA4 hydrolyzes retinyl palmitate" +xref: Reactome:R-HSA-975593 "PNLIP:CLPS hydrolyses RPALM to atROL and PALM" +xref: Reactome:R-HSA-975594 "PLB1 hydrolyses RPALM to atROL" +xref: RHEA:21508 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050254 +name: rhodopsin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN] +synonym: "ATP:rhodopsin phosphotransferase activity" RELATED [EC:2.7.11.14] +synonym: "cone opsin kinase activity" NARROW [EC:2.7.11.14] +synonym: "G-protein-coupled receptor kinase 1 activity" NARROW [EC:2.7.11.14] +synonym: "GPCR kinase 1 activity" NARROW [EC:2.7.11.14] +synonym: "GRK1" RELATED [EC:2.7.11.14] +synonym: "GRK7" RELATED [EC:2.7.11.14] +synonym: "opsin kinase (phosphorylating) activity" RELATED [EC:2.7.11.14] +synonym: "opsin kinase activity" RELATED [EC:2.7.11.14] +synonym: "rhodopsin kinase (phosphorylating) activity" RELATED [EC:2.7.11.14] +synonym: "RK" RELATED [EC:2.7.11.14] +synonym: "STK14" RELATED [EC:2.7.11.14] +xref: EC:2.7.11.14 +xref: MetaCyc:2.7.11.14-RXN +xref: Reactome:R-HSA-2581474 "GRK1,4,7 phosphorylate MII to p-MII" +xref: RHEA:23356 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050255 +name: ribitol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.56, RHEA:20053] +synonym: "adonitol dehydrogenase activity" RELATED [EC:1.1.1.56] +synonym: "ribitol dehydrogenase A (wild type)" RELATED [EC:1.1.1.56] +synonym: "ribitol dehydrogenase B (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] +synonym: "ribitol dehydrogenase D (mutant enzyme with different properties)" RELATED [EC:1.1.1.56] +synonym: "ribitol:NAD+ 2-oxidoreductase activity" RELATED [EC:1.1.1.56] +xref: EC:1.1.1.56 +xref: KEGG_REACTION:R01895 +xref: MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN +xref: RHEA:20053 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050256 +name: ribitol-5-phosphate 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN] +synonym: "D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.137] +synonym: "dehydrogenase, ribitol 5-phosphate" RELATED [EC:1.1.1.137] +xref: EC:1.1.1.137 +xref: MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050257 +name: riboflavin phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20409] +synonym: "alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.42] +synonym: "D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity" RELATED [EC:2.7.1.42] +synonym: "G-1-P phosphotransferase activity" RELATED [EC:2.7.1.42] +synonym: "riboflavine phosphotransferase activity" RELATED [EC:2.7.1.42] +xref: EC:2.7.1.42 +xref: KEGG_REACTION:R00550 +xref: MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN +xref: RHEA:20409 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050258 +name: riboflavinase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11408] +synonym: "riboflavin hydrolase activity" RELATED [EC:3.5.99.1] +xref: EC:3.5.99.1 +xref: KEGG_REACTION:R01732 +xref: MetaCyc:RIBOFLAVINASE-RXN +xref: RHEA:11408 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0050259 +name: ribose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH." [EC:1.1.1.115, RHEA:11676] +synonym: "D-ribose dehydrogenase (NADP+)" RELATED [EC:1.1.1.115] +synonym: "D-ribose:NADP+ 1-oxidoreductase activity" RELATED [EC:1.1.1.115] +synonym: "NADP-pentose-dehydrogenase activity" RELATED [EC:1.1.1.115] +xref: EC:1.1.1.115 +xref: KEGG_REACTION:R01079 +xref: MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN +xref: RHEA:11676 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050260 +name: ribose-5-phosphate-ammonia ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.7, RHEA:13777] +synonym: "5-phosphoribosylamine synthetase activity" RELATED [EC:6.3.4.7] +synonym: "ammonia-ribose 5-phosphate aminotransferase activity" RELATED [EC:6.3.4.7] +synonym: "ribose 5-phosphate aminotransferase activity" RELATED [EC:6.3.4.7] +synonym: "ribose-5-phosphate:ammonia ligase (ADP-forming)" RELATED [EC:6.3.4.7] +xref: EC:6.3.4.7 +xref: KEGG_REACTION:R01053 +xref: MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN +xref: RHEA:13777 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0050261 +name: ribose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribofuranose = D-ribulose." [EC:5.3.1.20, RHEA:20796] +synonym: "D-ribose aldose-ketose-isomerase activity" RELATED [EC:5.3.1.20] +synonym: "D-ribose isomerase activity" RELATED [EC:5.3.1.20] +synonym: "D-ribose ketol-isomerase activity" RELATED [EC:5.3.1.20] +xref: EC:5.3.1.20 +xref: KEGG_REACTION:R01081 +xref: MetaCyc:RIBOSE-ISOMERASE-RXN +xref: RHEA:20796 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0050262 +name: ribosylnicotinamide kinase activity +namespace: molecular_function +alt_id: GO:0000816 +def: "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, PMID:17914902, RHEA:14017] +synonym: "ATP:N-ribosylnicotinamide 5'-phosphotransferase activity" RELATED [EC:2.7.1.22] +synonym: "nicotinamide riboside kinase activity" EXACT [PMID:15137942] +synonym: "ribosylnicotinamide kinase (phosphorylating)" RELATED [EC:2.7.1.22] +xref: EC:2.7.1.22 +xref: KEGG_REACTION:R02324 +xref: MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN +xref: Reactome:R-HSA-8869627 "NMRK2 phosphorylates NR to yield NMN" +xref: Reactome:R-HSA-8869633 "NMRK1 phosphorylates NR to yield NMN" +xref: RHEA:14017 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050263 +name: ribosylpyrimidine nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN] +synonym: "N-ribosylpyrimidine nucleosidase activity" RELATED [EC:3.2.2.8] +synonym: "N-ribosylpyrimidine ribohydrolase activity" RELATED [EC:3.2.2.8] +synonym: "nucleoside ribohydrolase activity" BROAD [EC:3.2.2.8] +synonym: "pyrimidine nucleosidase activity" RELATED [EC:3.2.2.8] +synonym: "pyrimidine-nucleoside ribohydrolase activity" RELATED [EC:3.2.2.8] +synonym: "RihB" RELATED [EC:3.2.2.8] +synonym: "YeiK" RELATED [EC:3.2.2.8] +xref: EC:3.2.2.8 +xref: MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN +xref: RHEA:56816 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0050264 +name: rifamycin-B oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O." [EC:1.10.3.6, RHEA:11292] +synonym: "rifamycin B oxidase activity" RELATED [EC:1.10.3.6] +synonym: "rifamycin-B-oxidase activity" EXACT [] +synonym: "rifamycin-B:oxygen oxidoreductase activity" RELATED [EC:1.10.3.6] +xref: EC:1.10.3.6 +xref: KEGG_REACTION:R03736 +xref: MetaCyc:RIFAMYCIN-B-OXIDASE-RXN +xref: RHEA:11292 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0050265 +name: RNA uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] +synonym: "poly(U) polymerase activity" EXACT [GOC:dph, GOC:mah] +synonym: "polynucleotide uridylyltransferase activity" EXACT [GOC:dph, GOC:mah] +synonym: "terminal uridylyltransferase activity" RELATED [EC:2.7.7.52] +synonym: "TUT activity" RELATED [EC:2.7.7.52] +synonym: "UTP:RNA uridylyltransferase activity" EXACT [] +xref: EC:2.7.7.52 +xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN +xref: Reactome:R-HSA-8941312 "ZCCHC6, ZCCHC11 are mRNA uridyltransferases" +xref: RHEA:14785 +is_a: GO:0070569 ! uridylyltransferase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0050266 +name: rosmarinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN] +synonym: "4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity" RELATED [EC:2.3.1.140] +synonym: "caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity" RELATED [EC:2.3.1.140] +synonym: "caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity" RELATED [EC:2.3.1.140] +synonym: "rosmarinic acid synthase activity" RELATED [EC:2.3.1.140] +xref: EC:2.3.1.140 +xref: MetaCyc:ROSMARINATE-SYNTHASE-RXN +xref: RHEA:22344 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050267 +name: rubber cis-polyprenylcistransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN] +synonym: "cis-prenyl transferase activity" RELATED [EC:2.5.1.20] +synonym: "isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity" RELATED [EC:2.5.1.20] +synonym: "poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity" RELATED [EC:2.5.1.20] +synonym: "rubber allyltransferase activity" RELATED [EC:2.5.1.20] +synonym: "rubber polymerase activity" RELATED [EC:2.5.1.20] +synonym: "rubber prenyltransferase activity" RELATED [EC:2.5.1.20] +synonym: "rubber transferase activity" BROAD [EC:2.5.1.20] +xref: EC:2.5.1.20 +xref: MetaCyc:2.5.1.20-RXN +xref: RHEA:18801 +is_a: GO:0002094 ! polyprenyltransferase activity + +[Term] +id: GO:0050268 +name: coniferyl-alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107] +synonym: "coniferyl-alcohol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.194] +xref: EC:1.1.1.194 +xref: MetaCyc:RXN-2602 +xref: RHEA:22444 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050269 +name: coniferyl-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241] +synonym: "coniferyl aldehyde:NAD(P)+ oxidoreductase activity" RELATED [EC:1.2.1.68] +xref: EC:1.2.1.68 +xref: MetaCyc:RXN-1241 +is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0050270 +name: S-adenosylhomocysteine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+)." [EC:3.5.4.28, RHEA:20716] +synonym: "adenosylhomocysteine deaminase activity" RELATED [EC:3.5.4.28] +synonym: "S-adenosyl-L-homocysteine aminohydrolase activity" RELATED [EC:3.5.4.28] +xref: EC:3.5.4.28 +xref: KEGG_REACTION:R00193 +xref: MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN +xref: RHEA:20716 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050271 +name: S-alkylcysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN] +synonym: "alkyl cysteine lyase activity" RELATED [EC:4.4.1.6] +synonym: "alkylcysteine lyase activity" RELATED [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteinase activity" RELATED [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity" RELATED [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine lyase activity" RELATED [EC:4.4.1.6] +synonym: "S-alkyl-L-cysteine sulfoxide lyase activity" RELATED [EC:4.4.1.6] +synonym: "S-alkylcysteinase activity" RELATED [EC:4.4.1.6] +xref: EC:4.4.1.6 +xref: MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN +xref: RHEA:22424 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050272 +name: S-carboxymethylcysteine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+)." [EC:4.5.1.5, RHEA:22868] +synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate)" RELATED [EC:4.5.1.5] +synonym: "3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming)" RELATED [EC:4.5.1.5] +synonym: "S-carboxymethyl-L-cysteine synthase activity" RELATED [EC:4.5.1.5] +xref: EC:4.5.1.5 +xref: KEGG_REACTION:R04003 +xref: MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN +xref: RHEA:22868 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0050273 +name: S-succinylglutathione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate." [EC:3.1.2.13, RHEA:16713] +xref: EC:3.1.2.13 +xref: KEGG_REACTION:R00499 +xref: MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN +xref: RHEA:16713 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0050274 +name: salicyl-alcohol beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP." [EC:2.4.1.172, RHEA:11512] +synonym: "salicyl-alcohol b-D-glucosyltransferase activity" EXACT [] +synonym: "salicyl-alcohol glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.172] +synonym: "UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity" RELATED [EC:2.4.1.172] +synonym: "UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.172] +synonym: "uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity" RELATED [EC:2.4.1.172] +xref: EC:2.4.1.172 +xref: KEGG_REACTION:R03558 +xref: MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:11512 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050275 +name: scopoletin glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP." [EC:2.4.1.128, RHEA:20453] +synonym: "SGTase activity" RELATED [EC:2.4.1.128] +synonym: "UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.128] +synonym: "UDPglucose:scopoletin glucosyltransferase activity" RELATED [EC:2.4.1.128] +synonym: "UDPglucose:scopoletin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.128] +synonym: "uridine diphosphoglucose-scopoletin glucosyltransferase activity" RELATED [EC:2.4.1.128] +xref: EC:2.4.1.128 +xref: KEGG_REACTION:R03594 +xref: MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:20453 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050276 +name: scyllo-inosamine 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.65, RHEA:18605] +synonym: "ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity" RELATED [EC:2.7.1.65] +synonym: "ATP:inosamine phosphotransferase activity" RELATED [EC:2.7.1.65] +synonym: "scyllo-inosamine kinase (phosphorylating)" RELATED [EC:2.7.1.65] +synonym: "scyllo-inosamine kinase activity" EXACT [] +xref: EC:2.7.1.65 +xref: KEGG_REACTION:R03384 +xref: MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN +xref: RHEA:18605 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050277 +name: sedoheptulokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23844] +synonym: "ATP:sedoheptulose 7-phosphotransferase activity" RELATED [EC:2.7.1.14] +synonym: "heptulokinase activity" RELATED [EC:2.7.1.14] +synonym: "sedoheptulokinase (phosphorylating)" RELATED [EC:2.7.1.14] +xref: EC:2.7.1.14 +xref: KEGG_REACTION:R01844 +xref: MetaCyc:SEDOHEPTULOKINASE-RXN +xref: Reactome:R-HSA-8959719 "SHPK phosphorylates Sedo to Sedo7P" +xref: RHEA:23844 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050278 +name: sedoheptulose-bisphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN] +synonym: "SBPase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-bisphosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-diphosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose 1,7-diphosphate phosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose bisphosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose diphosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose-1,7-bisphosphatase activity" RELATED [EC:3.1.3.37] +synonym: "sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity" RELATED [EC:3.1.3.37] +xref: EC:3.1.3.37 +xref: MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN +xref: RHEA:17461 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050279 +name: sepiapterin deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN] +synonym: "sepiapterin aminohydrolase activity" RELATED [EC:3.5.4.24] +xref: EC:3.5.4.24 +xref: MetaCyc:SEPIAPTERIN-DEAMINASE-RXN +xref: RHEA:14025 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050280 +name: sequoyitol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.143, RHEA:11300] +synonym: "5-O-methyl-myo-inositol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.143] +xref: EC:1.1.1.143 +xref: KEGG_REACTION:R03497 +xref: MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN +xref: RHEA:11300 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050281 +name: serine-glyoxylate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN] +synonym: "L-serine:glyoxylate aminotransferase activity" RELATED [EC:2.6.1.45] +synonym: "serine--glyoxylate aminotransferase activity" EXACT [] +synonym: "SGAT activity" RELATED [EC:2.6.1.45] +xref: EC:2.6.1.45 +xref: MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN +xref: RHEA:19125 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050282 +name: serine 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN] +synonym: "L-serine:NAD oxidoreductase (deaminating) activity" RELATED [EC:1.4.1.7] +synonym: "L-serine:NAD+ 2-oxidoreductase (deaminating)" RELATED [EC:1.4.1.7] +synonym: "serine dehydrogenase activity" EXACT [] +xref: EC:1.4.1.7 +xref: MetaCyc:SERINE-DEHYDROGENASE-RXN +xref: RHEA:20884 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050283 +name: serine-sulfate ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN] +synonym: "(L-SOS)lyase activity" RELATED [EC:4.3.1.10] +synonym: "L-serine-O-sulfate ammonia-lyase (pyruvate-forming)" RELATED [EC:4.3.1.10] +synonym: "serine-sulphate ammonia-lyase activity" EXACT [] +xref: EC:4.3.1.10 +xref: MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN +xref: RHEA:15605 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0050284 +name: sinapate 1-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN] +synonym: "UDP-glucose:sinapate D-glucosyltransferase activity" RELATED [EC:2.4.1.120] +synonym: "UDPglucose:sinapate D-glucosyltransferase activity" RELATED [EC:2.4.1.120] +synonym: "UDPglucose:sinapic acid glucosyltransferase activity" RELATED [EC:2.4.1.120] +synonym: "uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity" RELATED [EC:2.4.1.120] +synonym: "uridine diphosphoglucose-sinapate glucosyltransferase activity" RELATED [EC:2.4.1.120] +xref: EC:2.4.1.120 +xref: MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:13305 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050285 +name: sinapine esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate." [EC:3.1.1.49, RHEA:10016] +synonym: "aromatic choline esterase activity" RELATED [EC:3.1.1.49] +synonym: "sinapoylcholine sinapohydrolase activity" RELATED [EC:3.1.1.49] +xref: EC:3.1.1.49 +xref: KEGG_REACTION:R02381 +xref: MetaCyc:SINAPINE-ESTERASE-RXN +xref: RHEA:10016 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050286 +name: sorbitol-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24580] +synonym: "sorbitol-6-phosphate phosphatase activity" RELATED [EC:3.1.3.50] +synonym: "sorbitol-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.50] +xref: EC:3.1.3.50 +xref: KEGG_REACTION:R02866 +xref: MetaCyc:SORBITOL-6-PHOSPHATASE-RXN +xref: RHEA:24580 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050287 +name: sorbose 5-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH." [EC:1.1.1.123, RHEA:15001] +synonym: "5-keto-D-fructose reductase activity" RELATED [EC:1.1.1.123] +synonym: "5-ketofructose reductase activity" RELATED [EC:1.1.1.123] +synonym: "L-sorbose:NADP+ 5-oxidoreductase activity" RELATED [EC:1.1.1.123] +synonym: "reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity" RELATED [EC:1.1.1.123] +synonym: "sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" RELATED [EC:1.1.1.123] +xref: EC:1.1.1.123 +xref: KEGG_REACTION:R01694 +xref: MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN +xref: RHEA:15001 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050288 +name: sorbose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14713] +synonym: "L-sorbose:(acceptor) 5-oxidoreductase activity" RELATED [EC:1.1.99.12] +synonym: "L-sorbose:acceptor 5-oxidoreductase activity" RELATED [EC:1.1.99.12] +xref: EC:1.1.99.12 +xref: KEGG_REACTION:R01696 +xref: MetaCyc:SORBOSE-DEHYDROGENASE-RXN +xref: RHEA:14713 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0050289 +name: spermidine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN] +synonym: "spermidine:(acceptor) oxidoreductase activity" RELATED [EC:1.5.99.6] +synonym: "spermidine:acceptor oxidoreductase activity" RELATED [EC:1.5.99.6] +xref: EC:1.5.99.6 +xref: MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN +xref: RHEA:14273 +is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors + +[Term] +id: GO:0050290 +name: sphingomyelin phosphodiesterase D activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+)." [EC:3.1.4.41, RHEA:20984] +synonym: "sphingomyelin ceramide-phosphohydrolase activity" RELATED [EC:3.1.4.41] +synonym: "sphingomyelinase D" RELATED [EC:3.1.4.41] +xref: EC:3.1.4.41 +xref: KEGG_REACTION:R02542 +xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN +xref: RHEA:20984 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0050291 +name: sphingosine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845] +synonym: "acyl-CoA:sphingosine N-acyltransferase activity" RELATED [EC:2.3.1.24] +synonym: "ceramide synthase activity" EXACT [] +synonym: "ceramide synthetase activity" RELATED [EC:2.3.1.24] +synonym: "dihydroceramide synthase activity" EXACT [] +synonym: "sphingosine acyltransferase activity" RELATED [EC:2.3.1.24] +xref: EC:2.3.1.24 +xref: MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN +xref: Reactome:R-HSA-428185 "sphinganine + stearyl-CoA => dihydroceramide + CoASH" +xref: RHEA:23768 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0050292 +name: steroid 9-alpha-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O." [EC:1.14.99.24, RHEA:19557] +synonym: "steroid 9-alpha-hydroxylase activity" RELATED [EC:1.14.99.24] +synonym: "steroid 9a-monooxygenase activity" EXACT [] +synonym: "steroid 9alpha-hydroxylase activity" RELATED [EC:1.14.99.24] +synonym: "steroid 9alpha-monooxygenase activity" RELATED [EC:1.14.99.24] +synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)" RELATED [EC:1.14.99.24] +xref: EC:1.14.99.24 +xref: KEGG_REACTION:R04392 +xref: MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN +xref: RHEA:19557 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050293 +name: steroid-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate." [EC:3.1.1.37, RHEA:13721] +synonym: "testololactone lactonohydrolase activity" RELATED [EC:3.1.1.37] +xref: EC:3.1.1.37 +xref: KEGG_REACTION:R03641 +xref: MetaCyc:STEROID-LACTONASE-RXN +xref: RHEA:13721 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050294 +name: steroid sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] +subset: goslim_chembl +synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" RELATED [EC:2.8.2.15] +synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] +synonym: "steroid sulphotransferase activity" EXACT [] +xref: EC:2.8.2.15 +xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN +xref: Reactome:R-HSA-176517 "SULTs transfer (SO4)2- group to PREG" +xref: Reactome:R-HSA-176521 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP" +xref: Reactome:R-HSA-176631 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050295 +name: steryl-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11956] +synonym: "cholesteryl-beta-D-glucoside glucohydrolase activity" RELATED [EC:3.2.1.104] +synonym: "steryl-b-glucosidase activity" EXACT [] +xref: EC:3.2.1.104 +xref: KEGG_REACTION:R01460 +xref: MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN +xref: RHEA:11956 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0050296 +name: stipitatonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate." [EC:4.1.1.60, RHEA:13885] +synonym: "stipitatonate carboxy-lyase (decyclizing)" RELATED [EC:4.1.1.60] +synonym: "stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)" RELATED [EC:4.1.1.60] +xref: EC:4.1.1.60 +xref: KEGG_REACTION:R03739 +xref: MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN +xref: RHEA:13885 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050297 +name: stizolobate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN] +synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing)" RELATED [EC:1.13.11.29] +xref: EC:1.13.11.29 +xref: MetaCyc:STIZOLOBATE-SYNTHASE-RXN +xref: RHEA:21220 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050298 +name: stizolobinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN] +synonym: "3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)" RELATED [EC:1.13.11.30] +xref: EC:1.13.11.30 +xref: MetaCyc:STIZOLOBINATE-SYNTHASE-RXN +xref: RHEA:18465 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050299 +name: streptomycin 3''-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18377] +synonym: "ATP:streptomycin 3''-phosphotransferase activity" RELATED [EC:2.7.1.87] +synonym: "streptomycin 3''-kinase (phosphorylating)" RELATED [EC:2.7.1.87] +synonym: "streptomycin 3''-phosphotransferase activity" RELATED [EC:2.7.1.87] +xref: EC:2.7.1.87 +xref: KEGG_REACTION:R02227 +xref: MetaCyc:STREPTOMYCIN-3-KINASE-RXN +xref: RHEA:18377 +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0050300 +name: aminoglycoside 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22268] +synonym: "APH(6) activity" RELATED [EC:2.7.1.72] +synonym: "ATP:streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] +synonym: "SM 6-kinase activity" NARROW [EC:2.7.1.72] +synonym: "streptidine kinase (phosphorylating)" NARROW [EC:2.7.1.72] +synonym: "streptidine kinase activity" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-kinase (phosphorylating)" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-kinase activity" NARROW [] +synonym: "streptomycin 6-O-phosphotransferase activity" NARROW [EC:2.7.1.72] +synonym: "streptomycin 6-phosphotransferase activity" NARROW [EC:2.7.1.72] +xref: EC:2.7.1.72 +xref: KEGG_REACTION:R02225 +xref: MetaCyc:STREPTOMYCIN-6-KINASE-RXN +xref: RHEA:22268 +is_a: GO:0034071 ! aminoglycoside phosphotransferase activity + +[Term] +id: GO:0050301 +name: streptomycin-6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10688] +synonym: "streptomycin 6-phosphate phosphatase activity" RELATED [EC:3.1.3.39] +synonym: "streptomycin 6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.39] +synonym: "streptomycin-6-P phosphohydrolase activity" RELATED [EC:3.1.3.39] +synonym: "streptomycin-6-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.39] +xref: EC:3.1.3.39 +xref: KEGG_REACTION:R02228 +xref: MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN +xref: RHEA:10688 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050302 +name: indole-3-acetaldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+)." [EC:1.2.3.7, RHEA:16277] +synonym: "(indol-3-yl)acetaldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.7] +synonym: "AO1" RELATED [EC:1.2.3.7] +synonym: "IAA oxidase activity" RELATED [EC:1.2.3.7] +synonym: "IAAld oxidase activity" RELATED [EC:1.2.3.7] +synonym: "indole-3-acetaldehyde:oxygen oxidoreductase activity" RELATED [EC:1.2.3.7] +synonym: "indoleacetaldehyde oxidase activity" RELATED [EC:1.2.3.7] +xref: EC:1.2.3.7 +xref: KEGG_REACTION:R02681 +xref: MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN +xref: RHEA:16277 +is_a: GO:0018488 ! aryl-aldehyde oxidase activity + +[Term] +id: GO:0050303 +name: lysine 6-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN, RHEA:12408] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "L-lysine 6-dehydrogenase activity" RELATED [EC:1.4.1.18] +synonym: "L-lysine epsilon-dehydrogenase activity" RELATED [EC:1.4.1.18] +synonym: "L-lysine:NAD+ 6-oxidoreductase (deaminating)" RELATED [EC:1.4.1.18] +synonym: "LysDH activity" RELATED [EC:1.4.1.18] +xref: EC:1.4.1.18 +xref: MetaCyc:LYSINE-6-DEHYDROGENASE-RXN +xref: MetaCyc:PWY-5314 +xref: RHEA:12408 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050304 +name: nitrous-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide." [EC:1.7.2.4, MetaCyc:RXN-12130] +synonym: "N2O reductase activity" RELATED [EC:1.7.2.4] +synonym: "nitrogen:(acceptor) oxidoreductase (N2O-forming)" RELATED [EC:1.7.2.4] +synonym: "nitrogen:acceptor oxidoreductase (N2O-forming)" RELATED [EC:1.7.2.4] +synonym: "nitrous oxide reductase activity" RELATED [EC:1.7.2.4] +xref: EC:1.7.2.4 +xref: KEGG_REACTION:R02804 +xref: MetaCyc:RXN-12130 +xref: RHEA:43108 +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0050305 +name: strombine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate." [EC:1.5.1.22, RHEA:14061] +synonym: "N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity" RELATED [EC:1.5.1.22] +synonym: "N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)" RELATED [EC:1.5.1.22] +synonym: "strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity" RELATED [EC:1.5.1.22] +xref: EC:1.5.1.22 +xref: KEGG_REACTION:R00368 +xref: MetaCyc:STROMBINE-DEHYDROGENASE-RXN +xref: RHEA:14061 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050306 +name: sucrose 1F-fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN] +synonym: "SST activity" RELATED [EC:2.4.1.99] +synonym: "sucrose 1(F)-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose-sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose:sucrose 1'-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose:sucrose 1-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose:sucrose 1F-beta-D-fructosyltransferase activity" RELATED [EC:2.4.1.99] +synonym: "sucrose:sucrose fructosyltransferase activity" RELATED [EC:2.4.1.99] +xref: EC:2.4.1.99 +xref: MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN +xref: RHEA:23312 +is_a: GO:0050738 ! fructosyltransferase activity + +[Term] +id: GO:0050307 +name: sucrose-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN] +synonym: "sucrose-6F-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.24] +synonym: "sucrose-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.24] +xref: EC:3.1.3.24 +xref: KEGG_REACTION:R00805 +xref: KEGG_REACTION:R06211 +xref: MetaCyc:SUCROSE-PHOSPHATASE-RXN +xref: RHEA:19289 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0050308 +name: sugar-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN] +synonym: "sugar-phosphate phosphatase activity" EXACT [] +synonym: "sugar-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.23] +xref: EC:3.1.3.23 +xref: KEGG_REACTION:R00804 +xref: MetaCyc:SUGAR-PHOSPHATASE-RXN +is_a: GO:0019203 ! carbohydrate phosphatase activity + +[Term] +id: GO:0050309 +name: sugar-terminal-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN] +synonym: "sugar-omega-phosphate phosphohydrolase activity" EXACT systematic_synonym [EC:3.1.3.58] +synonym: "xylitol-5-phosphatase activity" NARROW [EC:3.1.3.58] +xref: EC:3.1.3.58 +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0050310 +name: sulfite dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN] +synonym: "sulfite cytochrome c reductase activity" RELATED [EC:1.8.2.1] +synonym: "sulfite-cytochrome c oxidoreductase activity" RELATED [EC:1.8.2.1] +synonym: "sulfite:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.8.2.1] +synonym: "sulphite dehydrogenase activity" EXACT [] +xref: EC:1.8.2.1 +xref: MetaCyc:SULFITE-DEHYDROGENASE-RXN +xref: RHEA:14281 +is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor + +[Term] +id: GO:0050311 +name: sulfite reductase (ferredoxin) activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN] +synonym: "ferredoxin-sulfite reductase activity" RELATED [EC:1.8.7.1] +synonym: "hydrogen-sulfide:ferredoxin oxidoreductase activity" RELATED [EC:1.8.7.1] +synonym: "sulphite reductase (ferredoxin) activity" EXACT [] +xref: EC:1.8.7.1 +xref: MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN +xref: RHEA:23132 +is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050312 +name: sulfoacetaldehyde lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN] +comment: Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). +synonym: "sulphoacetaldehyde lyase activity" EXACT [] +xref: EC:4.4.1.- +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050313 +name: sulfur dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfur + O2 + H2O = sulfite." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN] +synonym: "S-sulfanylglutathione:oxygen oxidoreductase activity" RELATED [EC:1.13.11.18] +synonym: "sulfur oxygenase activity" RELATED [EC:1.13.11.18] +synonym: "sulfur:oxygen oxidoreductase activity" RELATED [EC:1.13.11.18] +synonym: "sulphur dioxygenase activity" EXACT [] +xref: EC:1.13.11.18 +xref: MetaCyc:FESGSHTHIO-RXN +xref: Reactome:R-HSA-1614605 "Persulfide sulfur is dioxygenated" +xref: RHEA:12981 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050314 +name: sym-norspermidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+)." [EC:2.5.1.23, RHEA:23244] +synonym: "S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity" RELATED [EC:2.5.1.23] +xref: EC:2.5.1.23 +xref: KEGG_REACTION:R03271 +xref: MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN +xref: RHEA:23244 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050315 +name: synephrine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:32203] +synonym: "1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming)" RELATED [EC:4.2.1.88] +xref: EC:4.2.1.88 +xref: KEGG_REACTION:R03359 +xref: MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN +xref: RHEA:32203 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050316 +name: T2-induced deoxynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN] +synonym: "ATP:(d)NMP phosphotransferase activity" RELATED [EC:2.7.4.12] +xref: EC:2.7.4.12 +xref: MetaCyc:GMKALT-RXN +xref: RHEA:12697 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0050317 +name: tagatose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.101, RHEA:15513] +synonym: "ATP:D-tagatose 6-phosphotransferase activity" RELATED [EC:2.7.1.101] +synonym: "D-tagatose 6-phosphate kinase activity" RELATED [EC:2.7.1.101] +synonym: "tagatose 6-phosphate kinase (phosphorylating)" RELATED [EC:2.7.1.101] +xref: EC:2.7.1.101 +xref: KEGG_REACTION:R02927 +xref: MetaCyc:TAGATOSE-KINASE-RXN +xref: RHEA:15513 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050318 +name: tannase activity +namespace: molecular_function +def: "Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+)." [EC:3.1.1.20, RHEA:16365] +synonym: "tannase S" RELATED [EC:3.1.1.20] +synonym: "tannin acetylhydrolase activity" RELATED [EC:3.1.1.20] +synonym: "tannin acylhydrolase activity" RELATED [EC:3.1.1.20] +xref: EC:3.1.1.20 +xref: KEGG_REACTION:R00053 +xref: MetaCyc:TANNASE-RXN +xref: RHEA:16365 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050319 +name: tartrate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2)." [EC:4.1.1.73, RHEA:13317] +synonym: "(R,R)-tartrate carboxy-lyase (D-glycerate-forming)" RELATED [EC:4.1.1.73] +synonym: "(R,R)-tartrate carboxy-lyase activity" RELATED [EC:4.1.1.73] +xref: EC:4.1.1.73 +xref: KEGG_REACTION:R01751 +xref: MetaCyc:TARTRATE-DECARBOXYLASE-RXN +xref: RHEA:13317 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050320 +name: tartrate epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate." [EC:5.1.2.5, RHEA:22212] +synonym: "tartaric racemase activity" RELATED [EC:5.1.2.5] +xref: EC:5.1.2.5 +xref: KEGG_REACTION:R02546 +xref: MetaCyc:TARTRATE-EPIMERASE-RXN +xref: RHEA:22212 +is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives + +[Term] +id: GO:0050321 +name: tau-protein kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN] +synonym: "[Tau protein] kinase activity" EXACT [] +synonym: "ATP:tau-protein O-phosphotransferase activity" BROAD [EC:2.7.11.26] +synonym: "brain protein kinase PK40erk activity" NARROW [EC:2.7.11.26] +synonym: "cdk5/p20" RELATED [EC:2.7.11.26] +synonym: "CDK5/p23" RELATED [EC:2.7.11.26] +synonym: "glycogen synthase kinase-3beta activity" RELATED [] +synonym: "GSK" RELATED [EC:2.7.11.26] +synonym: "protein tau kinase activity" RELATED [EC:2.7.11.26] +synonym: "STK31" RELATED [EC:2.7.11.26] +synonym: "tau kinase activity" RELATED [EC:2.7.11.26] +synonym: "tau protein kinase activity" RELATED [EC:2.7.11.26] +synonym: "tau-protein kinase I activity" NARROW [EC:2.7.11.26] +synonym: "tau-protein kinase II activity" NARROW [EC:2.7.11.26] +synonym: "tau-tubulin kinase activity" NARROW [EC:2.7.11.26] +synonym: "TPK" RELATED [EC:2.7.11.26] +synonym: "TPK I" RELATED [EC:2.7.11.26] +synonym: "TPK II" RELATED [EC:2.7.11.26] +synonym: "TTK" RELATED [EC:2.7.11.26] +xref: EC:2.7.11.26 +xref: MetaCyc:TAU-PROTEIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050322 +name: taurine-2-oxoglutarate transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:RXN-2301] +synonym: "taurine aminotransferase activity" EXACT [] +synonym: "taurine transaminase activity" EXACT [] +synonym: "taurine--alpha-ketoglutarate aminotransferase activity" RELATED [EC:2.6.1.55] +synonym: "taurine--glutamate transaminase activity" RELATED [EC:2.6.1.55] +synonym: "taurine:2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.55] +xref: EC:2.6.1.55 +xref: MetaCyc:RXN-2301 +xref: RHEA:16353 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0050323 +name: taurine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde." [EC:1.4.99.2, RHEA:18709] +synonym: "taurine:(acceptor) oxidoreductase (deaminating)" RELATED [EC:1.4.99.2] +synonym: "taurine:acceptor oxidoreductase (deaminating)" RELATED [EC:1.4.99.2] +xref: EC:1.4.99.2 +xref: KEGG_REACTION:R07167 +xref: MetaCyc:TAURINE-DEHYDROGENASE-RXN +xref: RHEA:18709 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0050324 +name: taurocyamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.4, RHEA:22516] +synonym: "ATP:taurocyamine N-phosphotransferase activity" RELATED [EC:2.7.3.4] +synonym: "ATP:taurocyamine phosphotransferase activity" RELATED [EC:2.7.3.4] +synonym: "taurocyamine phosphotransferase activity" RELATED [EC:2.7.3.4] +xref: EC:2.7.3.4 +xref: KEGG_REACTION:R03785 +xref: MetaCyc:TAUROCYAMINE-KINASE-RXN +xref: RHEA:22516 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor + +[Term] +id: GO:0050325 +name: tauropine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12580] +synonym: "2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" RELATED [EC:1.5.1.23] +synonym: "N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)" RELATED [EC:1.5.1.23] +xref: EC:1.5.1.23 +xref: KEGG_REACTION:R01683 +xref: MetaCyc:TAUROPINE-DEHYDROGENASE-RXN +xref: RHEA:12580 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050326 +name: taxifolin 8-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN] +synonym: "taxifolin hydroxylase activity" EXACT [] +synonym: "taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)" RELATED [EC:1.14.13.19] +xref: EC:1.14.13.19 +xref: MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050328 +name: tetrahydroberberine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN] +synonym: "(S)-tetrahydroberberine:oxygen oxidoreductase activity" RELATED [EC:1.3.3.8] +synonym: "(S)-THB oxidase activity" RELATED [EC:1.3.3.8] +synonym: "THB oxidase activity" RELATED [EC:1.3.3.8] +xref: EC:1.3.3.8 +xref: MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN +xref: RHEA:13489 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050329 +name: tetrahydroxypteridine cycloisomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18097] +synonym: "tetrahydroxypteridine lyase (isomerizing)" RELATED [EC:5.5.1.3] +xref: EC:5.5.1.3 +xref: KEGG_REACTION:R04154 +xref: MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN +xref: RHEA:18097 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0050330 +name: theanine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18013] +synonym: "5-N-ethyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.65] +synonym: "L-theanine amidohydrolase activity" RELATED [EC:3.5.1.65] +synonym: "N5-ethyl-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.65] +xref: EC:3.5.1.65 +xref: KEGG_REACTION:R02930 +xref: MetaCyc:THEANINE-HYDROLASE-RXN +xref: RHEA:18013 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050331 +name: thiamine-diphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN] +synonym: "ATP:thiamin-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15] +synonym: "ATP:thiamine-diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15] +synonym: "protein bound thiamin diphosphate:ATP phosphoryltransferase activity" RELATED [EC:2.7.4.15] +synonym: "TDP kinase activity" RELATED [EC:2.7.4.15] +synonym: "thiamin diphosphate kinase activity" EXACT [] +synonym: "thiamin diphosphate phosphotransferase activity" RELATED [EC:2.7.4.15] +synonym: "thiamin pyrophosphate kinase activity" RELATED [EC:2.7.4.15] +synonym: "thiamin-diphosphate kinase activity" EXACT [] +synonym: "thiamine diphosphate kinase activity" RELATED [EC:2.7.4.15] +xref: EC:2.7.4.15 +xref: MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN +xref: Reactome:R-HSA-997381 "TDPK phosphorylates ThDP to ThTP" +xref: RHEA:11240 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0050332 +name: thiamine pyridinylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17697] +synonym: "pyrimidine transferase activity" RELATED [EC:2.5.1.2] +synonym: "thiamin hydrolase activity" RELATED [EC:2.5.1.2] +synonym: "thiamin pyridinolase activity" RELATED [EC:2.5.1.2] +synonym: "thiamin pyridinylase activity" EXACT [] +synonym: "thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.2] +synonym: "thiaminase I activity" NARROW [EC:2.5.1.2] +synonym: "thiamine hydrolase activity" RELATED [EC:2.5.1.2] +synonym: "thiamine pyridinolase activity" RELATED [EC:2.5.1.2] +synonym: "thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" RELATED [EC:2.5.1.2] +xref: EC:2.5.1.2 +xref: KEGG_REACTION:R02863 +xref: MetaCyc:THIAMIN-PYRIDINYLASE-RXN +xref: RHEA:17697 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050333 +name: thiamin-triphosphatase activity +namespace: molecular_function +alt_id: GO:0048253 +def: "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate." [EC:3.6.1.28, RHEA:11744] +synonym: "thiamine-triphosphatase activity" EXACT [] +synonym: "thiamine-triphosphate phosphohydrolase activity" RELATED [EC:3.6.1.28] +synonym: "ThTPase activity" RELATED [EC:3.6.1.28] +xref: EC:3.6.1.28 +xref: KEGG_REACTION:R00618 +xref: MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN +xref: Reactome:R-HSA-965067 "THTPA:Mg2+ hydrolyzes ThTP to TDP" +xref: RHEA:11744 +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0050334 +name: thiaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)." [EC:3.5.99.2, RHEA:17509] +synonym: "thiaminase II activity" NARROW [EC:3.5.99.2] +xref: EC:3.5.99.2 +xref: KEGG_REACTION:R02133 +xref: MetaCyc:THIAMINASE-RXN +xref: RHEA:17509 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0050335 +name: thiocyanate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate." [EC:5.99.1.1, RHEA:10004] +synonym: "benzyl-thiocyanate isomerase activity" RELATED [EC:5.99.1.1] +synonym: "isothiocyanate isomerase activity" RELATED [EC:5.99.1.1] +xref: EC:5.99.1.1 +xref: KEGG_REACTION:R04010 +xref: MetaCyc:THIOCYANATE-ISOMERASE-RXN +xref: RHEA:10004 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0050336 +name: thioethanolamine S-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23280] +synonym: "acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity" RELATED [EC:2.3.1.11] +synonym: "acetyl-CoA:thioethanolamine S-acetyltransferase activity" RELATED [EC:2.3.1.11] +synonym: "thioethanolamine acetyltransferase activity" RELATED [EC:2.3.1.11] +synonym: "thioltransacetylase B activity" RELATED [EC:2.3.1.11] +xref: EC:2.3.1.11 +xref: KEGG_REACTION:R03668 +xref: MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN +xref: RHEA:23280 +is_a: GO:0016418 ! S-acetyltransferase activity + +[Term] +id: GO:0050337 +name: thiosulfate-thiol sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN] +synonym: "glutathione-dependent thiosulfate reductase activity" RELATED [EC:2.8.1.3] +synonym: "sulfane reductase activity" RELATED [EC:2.8.1.3] +synonym: "sulfane sulfurtransferase activity" RELATED [EC:2.8.1.3] +synonym: "thiosulfate:thiol sulfurtransferase activity" RELATED [EC:2.8.1.3] +synonym: "thiosulphate-thiol sulphurtransferase activity" EXACT [] +xref: EC:2.8.1.3 +xref: MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN +xref: Reactome:R-HSA-1655879 "Thiosulfate can transfer its sulfur atom to glutathione" +xref: RHEA:14505 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0050338 +name: thiosulfate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN] +synonym: "tetrathionate synthase activity" RELATED [EC:1.8.2.2] +synonym: "thiosulfate oxidase activity" RELATED [EC:1.8.2.2] +synonym: "thiosulfate-acceptor oxidoreductase activity" RELATED [EC:1.8.2.2] +synonym: "thiosulfate-oxidizing enzyme" RELATED [EC:1.8.2.2] +synonym: "thiosulfate:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.8.2.2] +synonym: "thiosulphate dehydrogenase activity" EXACT [] +xref: EC:1.8.2.2 +xref: MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN +xref: RHEA:20549 +is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor + +[Term] +id: GO:0050339 +name: thymidine-triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN] +synonym: "deoxythymidine-5'-triphosphatase activity" RELATED [EC:3.6.1.39] +synonym: "dTTP nucleotidohydrolase activity" RELATED [EC:3.6.1.39] +synonym: "dTTPase activity" RELATED [EC:3.6.1.39] +synonym: "thymidine triphosphate nucleotidohydrolase activity" RELATED [EC:3.6.1.39] +xref: EC:3.6.1.39 +xref: MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN +xref: RHEA:19013 +is_a: GO:0017111 ! nucleoside-triphosphatase activity + +[Term] +id: GO:0050340 +name: thymidylate 5'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN] +synonym: "deoxythymidylate 5'-nucleotidase activity" RELATED [EC:3.1.3.35] +synonym: "deoxythymidylate phosphohydrolase activity" RELATED [EC:3.1.3.35] +synonym: "deoxythymidylic 5'-nucleotidase activity" RELATED [EC:3.1.3.35] +synonym: "dTMPase activity" RELATED [EC:3.1.3.35] +synonym: "thymidylate 5' phosphatase activity" EXACT [] +synonym: "thymidylate 5'-nucleotidase activity" RELATED [EC:3.1.3.35] +synonym: "thymidylate 5'-phosphohydrolase activity" RELATED [EC:3.1.3.35] +synonym: "thymidylate nucleotidase activity" RELATED [EC:3.1.3.35] +xref: EC:3.1.3.35 +xref: MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN +xref: RHEA:11080 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050341 +name: thymine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN] +synonym: "5-hydroxy-methyluracil dioxygenase activity" RELATED [EC:1.14.11.6] +synonym: "5-hydroxymethyluracil oxygenase activity" RELATED [EC:1.14.11.6] +synonym: "thymine 7-hydroxylase activity" RELATED [EC:1.14.11.6] +synonym: "thymine,2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.6] +synonym: "thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)" RELATED [EC:1.14.11.6] +xref: EC:1.14.11.6 +xref: MetaCyc:THYMINE-DIOXYGENASE-RXN +xref: RHEA:10316 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0050342 +name: tocopherol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN] +synonym: "gamma-tocopherol methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity" RELATED [EC:2.1.1.95] +xref: EC:2.1.1.95 +xref: MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN +xref: RHEA:24012 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0050343 +name: trans-2-enoyl-CoA reductase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN] +synonym: "acyl-CoA:NAD+ trans-2-oxidoreductase activity" RELATED [EC:1.3.1.44] +xref: EC:1.3.1.44 +xref: MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN +xref: RHEA:18177 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050344 +name: trans-cinnamate 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+)." [EC:1.14.13.14, RHEA:10956] +synonym: "cinnamate 2-hydroxylase activity" RELATED [EC:1.14.13.14] +synonym: "cinnamate 2-monooxygenase activity" RELATED [EC:1.14.13.14] +synonym: "cinnamic 2-hydroxylase activity" RELATED [EC:1.14.13.14] +synonym: "cinnamic acid 2-hydroxylase activity" RELATED [EC:1.14.13.14] +synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)" RELATED [EC:1.14.13.14] +synonym: "trans-cinnamic acid 2-hydroxylase activity" EXACT [] +xref: EC:1.14.13.14 +xref: KEGG_REACTION:R02254 +xref: MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN +xref: RHEA:10956 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050345 +name: trans-epoxysuccinate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20740] +synonym: "tartrate epoxydase activity" RELATED [EC:3.3.2.4] +synonym: "trans-2,3-epoxysuccinate hydrolase activity" RELATED [EC:3.3.2.4] +synonym: "trans-epoxysuccinate hydratase activity" RELATED [EC:3.3.2.4] +xref: EC:3.3.2.4 +xref: KEGG_REACTION:R02547 +xref: MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN +xref: RHEA:20740 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0050346 +name: trans-L-3-hydroxyproline dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+)." [EC:4.2.1.77, RHEA:10320] +synonym: "trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming)" RELATED [EC:4.2.1.77] +synonym: "trans-L-3-hydroxyproline hydro-lyase activity" RELATED [EC:4.2.1.77] +xref: EC:4.2.1.77 +xref: KEGG_REACTION:R04374 +xref: MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN +xref: RHEA:10320 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050347 +name: trans-octaprenyltranstransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate." [RHEA:11324] +synonym: "(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity" RELATED [] +synonym: "all-trans-nonaprenyl-diphosphate synthase activity" RELATED [] +synonym: "nonaprenyl pyrophosphate synthetase activity" RELATED [] +synonym: "polyprenylpyrophosphate synthetase activity" RELATED [] +synonym: "solanesyl pyrophosphate synthetase activity" RELATED [] +synonym: "solanesyl-diphosphate synthase activity" RELATED [] +synonym: "SPP synthase activity" RELATED [] +synonym: "terpenoidallyltransferase activity" RELATED [] +synonym: "terpenyl pyrophosphate synthetase activity" RELATED [] +synonym: "trans-prenyltransferase activity" RELATED [] +xref: KEGG_REACTION:R07267 +xref: RHEA:11324 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0050348 +name: trehalose O-mycolyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23472] +synonym: "alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity" RELATED [EC:2.3.1.122] +synonym: "alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity" RELATED [EC:2.3.1.122] +xref: EC:2.3.1.122 +xref: KEGG_REACTION:R07248 +xref: MetaCyc:RXN1G-874 +xref: RHEA:23472 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050349 +name: triacetate-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + triacetate lactone = triacetate." [EC:3.1.1.38, RHEA:22260] +synonym: "TAL hydrolase activity" RELATED [EC:3.1.1.38] +synonym: "triacetate lactone hydrolase activity" RELATED [EC:3.1.1.38] +synonym: "triacetic acid lactone hydrolase activity" RELATED [EC:3.1.1.38] +synonym: "triacetic lactone hydrolase activity" RELATED [EC:3.1.1.38] +synonym: "triacetolactone lactonohydrolase activity" RELATED [EC:3.1.1.38] +xref: EC:3.1.1.38 +xref: KEGG_REACTION:R03702 +xref: MetaCyc:TRIACETATE-LACTONASE-RXN +xref: RHEA:22260 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050350 +name: trihydroxystilbene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN] +synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.95] +synonym: "resveratrol synthase activity" RELATED [EC:2.3.1.95] +synonym: "stilbene synthase activity" BROAD [EC:2.3.1.95] +xref: EC:2.3.1.95 +xref: MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN +xref: RHEA:11936 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050351 +name: trimetaphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate." [EC:3.6.1.2, RHEA:11088] +synonym: "inorganic trimetaphosphatase activity" RELATED [EC:3.6.1.2] +synonym: "trimetaphosphate hydrolase activity" RELATED [EC:3.6.1.2] +xref: EC:3.6.1.2 +xref: KEGG_REACTION:R02504 +xref: MetaCyc:TRIMETAPHOSPHATASE-RXN +xref: RHEA:11088 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0050352 +name: trimethylamine-oxide aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20217] +synonym: "trimethylamine N-oxide aldolase activity" RELATED [EC:4.1.2.32] +synonym: "trimethylamine N-oxide demethylase activity" RELATED [EC:4.1.2.32] +synonym: "trimethylamine N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.32] +synonym: "trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)" RELATED [EC:4.1.2.32] +synonym: "trimethylamine-N-oxide formaldehyde-lyase activity" RELATED [EC:4.1.2.32] +xref: EC:4.1.2.32 +xref: KEGG_REACTION:R02512 +xref: MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN +xref: RHEA:20217 +xref: UM-BBD_reactionID:r1409 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050353 +name: trimethyllysine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14181] +synonym: "6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.8] +synonym: "epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.8] +synonym: "N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" RELATED [EC:1.14.11.8] +synonym: "TML dioxygenase activity" RELATED [EC:1.14.11.8] +synonym: "TML hydroxylase activity" RELATED [EC:1.14.11.8] +synonym: "TML-alpha-ketoglutarate dioxygenase activity" RELATED [EC:1.14.11.8] +synonym: "TMLD activity" RELATED [EC:1.14.11.8] +synonym: "trimethyllysine alpha-ketoglutarate dioxygenase activity" RELATED [EC:1.14.11.8] +synonym: "trimethyllysine,2-oxoglutarate dioxygenase activity" RELATED [EC:1.14.11.8] +xref: EC:1.14.11.8 +xref: KEGG_REACTION:R03451 +xref: MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN +xref: Reactome:R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA" +xref: RHEA:14181 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0050354 +name: triokinase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.28, RHEA:13941] +synonym: "ATP:D-glyceraldehyde 3-phosphotransferase activity" RELATED [EC:2.7.1.28] +synonym: "D-triokinase activity" RELATED [EC:2.7.1.28] +synonym: "trio triose kinase (phosphorylating)" RELATED [EC:2.7.1.28] +synonym: "triose kinase activity" RELATED [EC:2.7.1.28] +xref: EC:2.7.1.28 +xref: KEGG_REACTION:R01059 +xref: MetaCyc:TRIOKINASE-RXN +xref: Reactome:R-HSA-70349 "DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate" +xref: RHEA:13941 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050355 +name: triphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14157] +synonym: "inorganic triphosphatase activity" RELATED [EC:3.6.1.25] +synonym: "triphosphate phosphohydrolase activity" RELATED [EC:3.6.1.25] +synonym: "tripolyphosphatase activity" EXACT [PMID:24004165] +xref: EC:3.6.1.25 +xref: KEGG_REACTION:R00138 +xref: MetaCyc:TRIPHOSPHATASE-RXN +xref: RHEA:14157 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050356 +name: tropine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone." [EC:1.1.1.206, RHEA:18357] +synonym: "tropine:NADP+ 3alpha-oxidoreductase activity" RELATED [EC:1.1.1.206] +xref: EC:1.1.1.206 +xref: KEGG_REACTION:R02832 +xref: MetaCyc:TROPINE-DEHYDROGENASE-RXN +xref: RHEA:18357 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050357 +name: tropinesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine." [EC:3.1.1.10, RHEA:23304] +synonym: "atropinase activity" RELATED [EC:3.1.1.10] +synonym: "atropine acylhydrolase activity" RELATED [EC:3.1.1.10] +synonym: "atropine esterase activity" RELATED [EC:3.1.1.10] +synonym: "atropinesterase activity" RELATED [EC:3.1.1.10] +synonym: "tropine esterase activity" RELATED [EC:3.1.1.10] +xref: EC:3.1.1.10 +xref: KEGG_REACTION:R03563 +xref: MetaCyc:TROPINESTERASE-RXN +xref: RHEA:23304 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050358 +name: tropinone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone." [EC:1.1.1.236, RHEA:24244] +synonym: "pseudotropine forming tropinone reductase activity" RELATED [EC:1.1.1.236] +synonym: "pseudotropine:NADP+ 3-oxidoreductase activity" RELATED [EC:1.1.1.236] +synonym: "tropinone (psi-tropine-forming) reductase activity" RELATED [EC:1.1.1.236] +synonym: "tropinone reductase II activity" RELATED [EC:1.1.1.236] +xref: EC:1.1.1.236 +xref: KEGG_REACTION:R06734 +xref: MetaCyc:TROPINONE-REDUCTASE-RXN +xref: RHEA:24244 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050359 +name: tropomyosin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN] +synonym: "ATP:tropomyosin O-phosphotransferase activity" RELATED [EC:2.7.11.28] +synonym: "STK" RELATED [EC:2.7.11.28] +synonym: "tropomyosin kinase (phosphorylating) activity" RELATED [EC:2.7.11.28] +xref: EC:2.7.11.28 +xref: MetaCyc:TROPOMYOSIN-KINASE-RXN +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050360 +name: tryptophan 2'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN] +synonym: "indole-3-alkane alpha-hydroxylase activity" RELATED [EC:1.13.99.3] +synonym: "indolyl-3-alkan alpha-hydroxylase activity" RELATED [EC:1.13.99.3] +synonym: "L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)" RELATED [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase activity" RELATED [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase II" RELATED [EC:1.13.99.3] +synonym: "tryptophan side chain oxidase type I" RELATED [EC:1.13.99.3] +synonym: "tryptophan side-chain alpha,beta-oxidase activity" RELATED [EC:1.13.99.3] +synonym: "tryptophan side-chain oxidase activity" RELATED [EC:1.13.99.3] +synonym: "TSO activity" RELATED [EC:1.13.99.3] +synonym: "TSO I" RELATED [EC:1.13.99.3] +synonym: "TSO II" RELATED [EC:1.13.99.3] +xref: EC:1.13.99.3 +xref: MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN +xref: RHEA:22620 +is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen + +[Term] +id: GO:0050361 +name: tryptophan 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16165] +synonym: "L-tryptophan:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.3] +xref: EC:1.13.12.3 +xref: KEGG_REACTION:R00679 +xref: MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN +xref: RHEA:16165 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050362 +name: L-tryptophan:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN] +synonym: "5-hydroxytryptophan-ketoglutaric transaminase activity" RELATED [EC:2.6.1.27] +synonym: "hydroxytryptophan aminotransferase activity" RELATED [EC:2.6.1.27] +synonym: "L-phenylalanine-2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.27] +synonym: "L-tryptophan aminotransferase activity" BROAD [EC:2.6.1.27] +synonym: "L-tryptophan transaminase activity" BROAD [EC:2.6.1.27] +synonym: "tryptophan aminotransferase activity" EXACT [] +synonym: "tryptophan transaminase activity" BROAD [EC:2.6.1.27] +xref: EC:2.6.1.27 +xref: MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN +xref: RHEA:14093 +is_a: GO:0070529 ! L-tryptophan aminotransferase activity + +[Term] +id: GO:0050363 +name: tryptophan dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN] +synonym: "L-Trp-dehydrogenase activity" RELATED [EC:1.4.1.19] +synonym: "L-tryptophan dehydrogenase activity" RELATED [EC:1.4.1.19] +synonym: "L-tryptophan:NAD(P)+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.19] +synonym: "NAD(P)+-L-tryptophan dehydrogenase activity" RELATED [EC:1.4.1.19] +synonym: "TDH" RELATED [EC:1.4.1.19] +synonym: "TrpDH activity" RELATED [EC:1.4.1.19] +xref: EC:1.4.1.19 +xref: MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050364 +name: tryptophan dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN] +synonym: "4-(gamma,gamma-dimethylallyl)tryptophan synthase activity" RELATED [EC:2.5.1.34] +synonym: "dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity" RELATED [EC:2.5.1.34] +synonym: "dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity" RELATED [EC:2.5.1.34] +synonym: "dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity" RELATED [EC:2.5.1.34] +synonym: "dimethylallyltryptophan synthetase activity" RELATED [EC:2.5.1.34] +synonym: "DMAT synthetase activity" RELATED [EC:2.5.1.34] +xref: EC:2.5.1.34 +xref: MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN +xref: RHEA:14173 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050365 +name: tryptophanamidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+)." [EC:3.5.1.57, RHEA:11012] +synonym: "L-tryptophan aminopeptidase" BROAD [EC:3.5.1.57] +synonym: "L-tryptophanamide amidohydrolase activity" RELATED [EC:3.5.1.57] +synonym: "tryptophan aminopeptidase" BROAD [EC:3.5.1.57] +xref: EC:3.5.1.57 +xref: KEGG_REACTION:R00682 +xref: MetaCyc:TRYPTOPHANAMIDASE-RXN +xref: RHEA:11012 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050366 +name: tyramine N-feruloyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN] +synonym: "feruloyl-CoA tyramine N-feruloyl-CoA transferase activity" RELATED [EC:2.3.1.110] +synonym: "feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity" RELATED [EC:2.3.1.110] +synonym: "feruloyltyramine synthase activity" RELATED [EC:2.3.1.110] +synonym: "tyramine feruloyltransferase activity" RELATED [EC:2.3.1.110] +synonym: "tyramine N-feruloyl-CoA transferase activity" RELATED [EC:2.3.1.110] +xref: EC:2.3.1.110 +xref: MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN +xref: RHEA:19685 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050367 +name: tyrosine-arginine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+)." [EC:6.3.2.24, RHEA:15345] +synonym: "kyotorphin synthase activity" RELATED [EC:6.3.2.24] +synonym: "kyotorphin synthetase activity" RELATED [EC:6.3.2.24] +synonym: "kyotorphin-synthesizing enzyme activity" RELATED [EC:6.3.2.24] +synonym: "L-tyrosine:L-arginine ligase (AMP-forming)" RELATED [EC:6.3.2.24] +synonym: "tyrosyl-arginine synthase activity" RELATED [EC:6.3.2.24] +xref: EC:6.3.2.24 +xref: KEGG_REACTION:R00735 +xref: MetaCyc:TYROSINE--ARGININE-LIGASE-RXN +xref: RHEA:15345 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050368 +name: tyrosine 2,3-aminomutase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, RHEA:15781] +synonym: "L-tyrosine 2,3-aminomutase activity" RELATED [EC:5.4.3.6] +synonym: "tyrosine alpha,beta-mutase activity" RELATED [EC:5.4.3.6] +xref: EC:5.4.3.6 +xref: KEGG_REACTION:R00739 +xref: MetaCyc:TYROSINE-23-AMINOMUTASE-RXN +xref: RHEA:15781 +is_a: GO:0016869 ! intramolecular transferase activity, transferring amino groups + +[Term] +id: GO:0050369 +name: [tyrosine 3-monooxygenase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN] +synonym: "ATP:tyrosine-3-monoxygenase phosphotransferase activity" RELATED [EC:2.7.11.6] +synonym: "pheochromocytoma tyrosine hydroxylase-associated kinase activity" RELATED [EC:2.7.11.6] +synonym: "STK4" RELATED [EC:2.7.11.6] +synonym: "tyrosine 3-monooxygenase kinase (phosphorylating) activity" RELATED [EC:2.7.11.6] +synonym: "tyrosine 3-monooxygenase kinase activity" EXACT [] +xref: EC:2.7.11.6 +xref: MetaCyc:2.7.11.6-RXN +xref: RHEA:17133 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050370 +name: tyrosine N-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN] +synonym: "CYP79A1 activity" NARROW [] +synonym: "L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)" EXACT [] +synonym: "tyrosine N-hydroxylase activity" EXACT [] +xref: MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN +xref: RHEA:22464 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050371 +name: tyrosine phenol-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate." [EC:4.1.99.2, RHEA:21704] +synonym: "beta-tyrosinase activity" RELATED [EC:4.1.99.2] +synonym: "L-tyrosine phenol-lyase (deaminating)" RELATED [EC:4.1.99.2] +synonym: "L-tyrosine phenol-lyase (deaminating; pyruvate-forming)" RELATED [EC:4.1.99.2] +xref: EC:4.1.99.2 +xref: KEGG_REACTION:R00728 +xref: MetaCyc:TYROSINE-PHENOL-LYASE-RXN +xref: RHEA:21704 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0050372 +name: ubiquitin-calmodulin ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN] +synonym: "calmodulin:ubiquitin ligase (AMP-forming)" RELATED [EC:6.3.2.21] +synonym: "ubiquitin-calmodulin synthetase activity" RELATED [EC:6.3.2.21] +synonym: "ubiquityl-calmodulin synthase activity" RELATED [EC:6.3.2.21] +synonym: "ubiquityl-calmodulin synthetase activity" RELATED [EC:6.3.2.21] +synonym: "uCaM-synthetase activity" RELATED [EC:6.3.2.21] +xref: MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN +is_a: GO:0004842 ! ubiquitin-protein transferase activity + +[Term] +id: GO:0050373 +name: UDP-arabinose 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose." [EC:5.1.3.5, RHEA:11320] +synonym: "UDP arabinose epimerase activity" RELATED [EC:5.1.3.5] +synonym: "UDP-D-xylose 4-epimerase activity" RELATED [EC:5.1.3.5] +synonym: "UDP-D-xylose-4-epimerase activity" EXACT [] +synonym: "UDP-L-arabinose 4-epimerase activity" RELATED [EC:5.1.3.5] +synonym: "UDParabinose 4-epimerase activity" RELATED [EC:5.1.3.5] +synonym: "uridine 5'-diphosphate-D-xylose 4-epimerase activity" RELATED [EC:5.1.3.5] +synonym: "uridine diphosphoarabinose epimerase activity" RELATED [EC:5.1.3.5] +xref: EC:5.1.3.5 +xref: KEGG_REACTION:R01473 +xref: MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN +xref: RHEA:11320 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050374 +name: UDP-galacturonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19725] +synonym: "UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)" RELATED [EC:4.1.1.67] +synonym: "UDP-D-galacturonate carboxy-lyase activity" RELATED [EC:4.1.1.67] +synonym: "UDP-galacturonic acid decarboxylase activity" RELATED [EC:4.1.1.67] +synonym: "UDPgalacturonate decarboxylase activity" RELATED [EC:4.1.1.67] +synonym: "UDPGalUA carboxy lyase activity" RELATED [EC:4.1.1.67] +xref: EC:4.1.1.67 +xref: KEGG_REACTION:R02636 +xref: MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN +xref: RHEA:19725 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050376 +name: UDP-glucosamine 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN] +synonym: "UDP-glucosamine epimerase activity" EXACT [] +synonym: "UDPglucosamine 4-epimerase activity" RELATED [EC:5.1.3.16] +xref: EC:5.1.3.16 +xref: MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN +xref: RHEA:23492 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050377 +name: UDP-glucose 4,6-dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21500] +synonym: "UDP-D-glucose oxidoreductase activity" RELATED [EC:4.2.1.76] +synonym: "UDP-D-glucose-4,6-hydrolyase activity" RELATED [EC:4.2.1.76] +synonym: "UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)" RELATED [EC:4.2.1.76] +synonym: "UDP-glucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.76] +synonym: "UDPglucose 4,6-dehydratase activity" RELATED [EC:4.2.1.76] +synonym: "UDPglucose 4,6-hydro-lyase activity" RELATED [EC:4.2.1.76] +xref: EC:4.2.1.76 +xref: KEGG_REACTION:R00293 +xref: MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN +xref: RHEA:21500 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050378 +name: UDP-glucuronate 4-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11404] +comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. +synonym: "UDP glucuronic epimerase activity" RELATED [EC:5.1.3.6] +synonym: "UDP-D-galacturonic acid 4-epimerase activity" RELATED [EC:5.1.3.6] +synonym: "UDP-galacturonate 4-epimerase activity" RELATED [EC:5.1.3.6] +synonym: "UDPglucuronate 4-epimerase activity" RELATED [EC:5.1.3.6] +synonym: "uridine diphospho-D-galacturonic acid" RELATED [EC:5.1.3.6] +synonym: "uridine diphosphoglucuronate epimerase activity" RELATED [EC:5.1.3.6] +synonym: "uridine diphosphoglucuronic epimerase activity" RELATED [EC:5.1.3.6] +xref: EC:5.1.3.6 +xref: KEGG_REACTION:R01385 +xref: MetaCyc:PWY-4861 +xref: MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN +xref: RHEA:11404 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050379 +name: UDP-glucuronate 5'-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate." [GOC:curators] +synonym: "C-5-uronosyl epimerase activity" RELATED [] +synonym: "UDP-glucuronate 5' epimerase activity" EXACT [] +synonym: "UDP-glucuronic acid 5'-epimerase activity" RELATED [] +synonym: "UDP-glucuronic acid epimerase activity" RELATED [] +synonym: "UDPglucuronate 5'-epimerase activity" RELATED [] +synonym: "uridine diphosphoglucuronate 5'-epimerase activity" RELATED [] +xref: KEGG_REACTION:R01387 +xref: MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN +xref: Reactome:R-HSA-2024100 "GLCE epimerises GlcA to IdoA" +xref: Reactome:R-HSA-2076371 "GLCE epimerises more GlcA to IdoA as sulfate content rises" +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050380 +name: undecaprenyl-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate." [PMID:18411271, RHEA:28094] +synonym: "C(55)-isoprenyl diphosphatase activity" RELATED [EC:3.6.1.27] +synonym: "C(55)-isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27] +synonym: "C55-isoprenyl diphosphatase activity" RELATED [EC:3.6.1.27] +synonym: "C55-isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27] +synonym: "isoprenyl pyrophosphatase activity" RELATED [EC:3.6.1.27] +synonym: "undecaprenyl-diphosphate phosphohydrolase activity" RELATED [EC:3.6.1.27] +xref: EC:3.6.1.27 +xref: KEGG_REACTION:R05627 +xref: MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN +xref: RHEA:28094 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0050382 +name: uracil-5-carboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil." [EC:4.1.1.66, RHEA:17685] +synonym: "uracil-5-carboxylate carboxy-lyase (uracil-forming)" RELATED [EC:4.1.1.66] +synonym: "uracil-5-carboxylate carboxy-lyase activity" RELATED [EC:4.1.1.66] +synonym: "uracil-5-carboxylic acid decarboxylase activity" RELATED [EC:4.1.1.66] +xref: EC:4.1.1.66 +xref: KEGG_REACTION:R00973 +xref: MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN +xref: RHEA:17685 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050383 +name: uracil dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [RHEA:22752] +xref: EC:1.17.99.4 +xref: MetaCyc:URACIL-DEHYDROGENASE-RXN +xref: RHEA:22752 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0050384 +name: urate-ribonucleotide phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate." [EC:2.4.2.16, RHEA:13909] +synonym: "UAR phosphorylase activity" RELATED [EC:2.4.2.16] +synonym: "urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity" RELATED [EC:2.4.2.16] +synonym: "urate-ribonucleotide:phosphate D-ribosyltransferase activity" RELATED [EC:2.4.2.16] +xref: EC:2.4.2.16 +xref: KEGG_REACTION:R02646 +xref: MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN +xref: RHEA:13909 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0050385 +name: ureidoglycolate lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea." [EC:4.3.2.3, RHEA:11304] +comment: Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. +synonym: "(S)-ureidoglycolate urea-lyase (glyoxylate-forming)" RELATED [EC:4.3.2.3] +synonym: "(S)-ureidoglycolate urea-lyase activity" RELATED [EC:4.3.2.3] +synonym: "ureidoglycolase activity" RELATED [EC:4.3.2.3] +synonym: "ureidoglycolatase activity" RELATED [EC:4.3.2.3] +synonym: "ureidoglycolate hydrolase activity" RELATED [PMID:24107613] +xref: EC:4.3.2.3 +xref: KEGG_REACTION:R00776 +xref: MetaCyc:UREIDOGLYCOLATE-LYASE-RXN +xref: RHEA:11304 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0050386 +name: ureidosuccinase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+)." [EC:3.5.1.7, RHEA:14365] +synonym: "N-carbamoyl-L-aspartate amidohydrolase activity" RELATED [EC:3.5.1.7] +xref: EC:3.5.1.7 +xref: KEGG_REACTION:R00484 +xref: MetaCyc:UREIDOSUCCINASE-RXN +xref: RHEA:14365 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050387 +name: urethanase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+)." [EC:3.5.1.75, RHEA:21372] +synonym: "urethane amidohydrolase (decarboxylating)" RELATED [EC:3.5.1.75] +synonym: "urethane hydrolase activity" RELATED [EC:3.5.1.75] +xref: EC:3.5.1.75 +xref: KEGG_REACTION:R02359 +xref: MetaCyc:URETHANASE-RXN +xref: RHEA:21372 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050388 +name: uronate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH." [EC:1.1.1.203, RHEA:22404] +synonym: "uronate: NAD-oxidoreductase activity" RELATED [EC:1.1.1.203] +synonym: "uronate:NAD+ 1-oxidoreductase activity" RELATED [EC:1.1.1.203] +synonym: "uronic acid dehydrogenase activity" RELATED [EC:1.1.1.203] +xref: EC:1.1.1.203 +xref: KEGG_REACTION:R01981 +xref: MetaCyc:URONATE-DEHYDROGENASE-RXN +xref: RHEA:22404 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050389 +name: uronolactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN] +synonym: "D-glucurono-6,2-lactone lactonohydrolase activity" RELATED [EC:3.1.1.19] +synonym: "glucuronolactonase activity" RELATED [EC:3.1.1.19] +xref: EC:3.1.1.19 +xref: MetaCyc:URONOLACTONASE-RXN +xref: RHEA:13337 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050390 +name: valine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2)." [EC:4.1.1.14, RHEA:18989] +synonym: "L-valine carboxy-lyase (2-methylpropanamine-forming)" RELATED [EC:4.1.1.14] +synonym: "L-valine carboxy-lyase activity" RELATED [EC:4.1.1.14] +synonym: "leucine decarboxylase activity" RELATED [EC:4.1.1.14] +xref: EC:4.1.1.14 +xref: KEGG_REACTION:R01437 +xref: MetaCyc:VALINE-DECARBOXYLASE-RXN +xref: RHEA:18989 +xref: UM-BBD_reactionID:r1052 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050391 +name: valine dehydrogenase (NADP) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN] +synonym: "L-valine:NADP+ oxidoreductase (deaminating)" RELATED [EC:1.4.1.8] +synonym: "valine dehydrogenase (NADP+) activity" EXACT [] +synonym: "valine dehydrogenase (nicotinanide adenine dinucleotide phosphate)" RELATED [EC:1.4.1.8] +xref: EC:1.4.1.8 +xref: MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN +xref: RHEA:11156 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050392 +name: vicianin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14041] +synonym: "(R)-vicianin beta-D-glucohydrolase activity" RELATED [EC:3.2.1.119] +synonym: "vicianin b-glucosidase activity" EXACT [] +synonym: "vicianin hydrolase activity" RELATED [EC:3.2.1.119] +xref: EC:3.2.1.119 +xref: KEGG_REACTION:R03642 +xref: MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN +xref: RHEA:14041 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0050393 +name: vinylacetyl-CoA delta-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: vinylacetyl-CoA = crotonoyl-CoA." [EC:5.3.3.3, RHEA:10572] +synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.3] +synonym: "vinylacetyl coenzyme A delta-isomerase activity" RELATED [EC:5.3.3.3] +synonym: "vinylacetyl coenzyme A isomerase activity" RELATED [EC:5.3.3.3] +synonym: "vinylacetyl-CoA D-isomerase activity" EXACT [] +synonym: "vinylacetyl-CoA delta3-delta2-isomerase activity" RELATED [EC:5.3.3.3] +xref: EC:5.3.3.3 +xref: KEGG_REACTION:R03031 +xref: MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN +xref: RHEA:10572 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0050394 +name: viomycin kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN] +synonym: "ATP:viomycin O-phosphotransferase activity" RELATED [EC:2.7.1.103] +synonym: "capreomycin phosphotransferase activity" RELATED [EC:2.7.1.103] +synonym: "viomycin phosphotransferase activity" RELATED [EC:2.7.1.103] +xref: EC:2.7.1.103 +xref: MetaCyc:VIOMYCIN-KINASE-RXN +xref: RHEA:20509 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050395 +name: vitexin beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21956] +synonym: "UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.105] +synonym: "UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.105] +synonym: "uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity" RELATED [EC:2.4.1.105] +synonym: "vitexin b-glucosyltransferase activity" EXACT [] +xref: EC:2.4.1.105 +xref: KEGG_REACTION:R03565 +xref: MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:21956 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050396 +name: vomifoliol 4'-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH." [EC:1.1.1.221, RHEA:22804] +synonym: "vomifoliol:NAD+ 4'-oxidoreductase activity" RELATED [EC:1.1.1.221] +xref: EC:1.1.1.221 +xref: KEGG_REACTION:R04412 +xref: MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN +xref: RHEA:22804 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050397 +name: Watasenia-luciferin 2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN] +synonym: "luciferase activity" BROAD [EC:1.13.12.8] +synonym: "Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)" RELATED [EC:1.13.12.8] +synonym: "Watasenia-type luciferase activity" RELATED [EC:1.13.12.8] +xref: EC:1.13.12.8 +xref: MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN +xref: RHEA:18057 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +is_a: GO:0045289 ! luciferin monooxygenase activity + +[Term] +id: GO:0050398 +name: wax-ester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN] +synonym: "jojoba wax esterase" NARROW [EC:3.1.1.50] +synonym: "wax-ester acylhydrolase activity" RELATED [EC:3.1.1.50] +synonym: "WEH" RELATED [EC:3.1.1.50] +xref: EC:3.1.1.50 +xref: MetaCyc:WAX-ESTER-HYDROLASE-RXN +xref: RHEA:13577 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050399 +name: xanthommatin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13417] +synonym: "5,12-dihydroxanthommatin:NAD+ oxidoreductase activity" RELATED [EC:1.3.1.41] +xref: EC:1.3.1.41 +xref: KEGG_REACTION:R03787 +xref: MetaCyc:XANTHOMMATIN-REDUCTASE-RXN +xref: RHEA:13417 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050400 +name: xylitol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20209] +synonym: "ATP:xylitol 5-phosphotransferase activity" RELATED [EC:2.7.1.122] +synonym: "xylitol phosphotransferase activity" RELATED [EC:2.7.1.122] +xref: EC:2.7.1.122 +xref: KEGG_REACTION:R02136 +xref: MetaCyc:XYLITOL-KINASE-RXN +xref: RHEA:20209 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050401 +name: xylonate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.82, RHEA:19157] +synonym: "D-xylo-aldonate dehydratase activity" RELATED [EC:4.2.1.82] +synonym: "D-xylonate dehydratase activity" RELATED [EC:4.2.1.82] +synonym: "D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)" RELATED [EC:4.2.1.82] +synonym: "D-xylonate hydro-lyase activity" RELATED [EC:4.2.1.82] +xref: EC:4.2.1.82 +xref: KEGG_REACTION:R02429 +xref: MetaCyc:XYLONATE-DEHYDRATASE-RXN +xref: RHEA:19157 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050402 +name: xylono-1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN] +synonym: "D-xylono-1,4-lactone lactonohydrolase activity" RELATED [EC:3.1.1.68] +synonym: "xylono-g-lactonase activity" RELATED [EC:3.1.1.68] +synonym: "xylonolactonase activity" RELATED [EC:3.1.1.68] +xref: EC:3.1.1.68 +xref: MetaCyc:XYLONO-14-LACTONASE-RXN +xref: RHEA:18341 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050403 +name: trans-zeatin O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP." [EC:2.4.1.203, RHEA:23224] +synonym: "UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203] +synonym: "UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203] +synonym: "uridine diphosphoglucose-zeatin O-glucosyltransferase activity" RELATED [EC:2.4.1.203] +synonym: "zeatin O-b-D-glucosyltransferase activity" EXACT [] +synonym: "zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.203] +synonym: "zeatin O-glucosyltransferase activity" RELATED [EC:2.4.1.203] +xref: EC:2.4.1.203 +xref: KEGG_REACTION:R02118 +xref: MetaCyc:RXN-4723 +xref: RHEA:23224 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050404 +name: zeatin O-beta-D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP." [EC:2.4.2.40, RHEA:14721] +comment: Note that this function was formerly EC:2.4.1.204. +synonym: "UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity" RELATED [EC:2.4.2.40] +synonym: "uridine diphosphoxylose-zeatin xylosyltransferase activity" RELATED [EC:2.4.2.40] +synonym: "zeatin O-b-D-xylosyltransferase activity" EXACT [] +synonym: "zeatin O-xylosyltransferase activity" RELATED [EC:2.4.2.40] +xref: EC:2.4.2.40 +xref: KEGG_REACTION:R02119 +xref: MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN +xref: RHEA:14721 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0050405 +name: [acetyl-CoA carboxylase] kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN] +synonym: "acetyl coenzyme A carboxylase kinase (phosphorylating) activity" RELATED [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase bound kinase activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase (AMP-activated) activity" RELATED [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase (cAMP-independent) activity" RELATED [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase 2 activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase activity" RELATED [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase-2 activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-CoA carboxylase kinase-3 (AMP-activated) activity" NARROW [EC:2.7.11.27] +synonym: "acetyl-coenzyme A carboxylase kinase activity" RELATED [EC:2.7.11.27] +synonym: "ACK2" RELATED [EC:2.7.11.27] +synonym: "ACK3" RELATED [EC:2.7.11.27] +synonym: "AMPK" RELATED [EC:2.7.11.27] +synonym: "ATP:acetyl-CoA carboxylase phosphotransferase activity" RELATED [EC:2.7.11.27] +synonym: "I-peptide kinase activity" NARROW [EC:2.7.11.27] +synonym: "STK5" RELATED [EC:2.7.11.27] +xref: EC:2.7.11.27 +xref: MetaCyc:2.7.11.27-RXN +xref: RHEA:20333 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0050406 +name: [acetyl-CoA carboxylase]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN] +synonym: "acetyl-CoA carboxylase-phosphatase activity" RELATED [EC:3.1.3.44] +synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.44] +xref: EC:3.1.3.44 +xref: MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN +xref: RHEA:17125 +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0050407 +name: [glycogen-synthase-D] phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN] +synonym: "glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "glycogen synthase D phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "glycogen synthase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "glycogen synthetase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "glycogen-synthase-D phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "Mg2+ dependent glycogen synthase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "phosphatase type 2oC" RELATED [EC:3.1.3.42] +synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" RELATED [EC:3.1.3.42] +synonym: "UDP-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "UDPglucose-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42] +synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity" RELATED [EC:3.1.3.42] +synonym: "uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity" RELATED [EC:3.1.3.42] +xref: EC:3.1.3.42 +xref: MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0050408 +name: [pyruvate kinase]-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN] +synonym: "ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.49] +synonym: "pyruvate kinase phosphatase activity" RELATED [EC:3.1.3.49] +synonym: "pyruvate kinase-phosphatase activity" RELATED [EC:3.1.3.49] +xref: EC:3.1.3.49 +xref: MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0050409 +name: indolylacetylinositol arabinosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP." [EC:2.4.2.34, RHEA:19505] +synonym: "arabinosylindolylacetylinositol synthase activity" RELATED [EC:2.4.2.34] +synonym: "UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity" RELATED [EC:2.4.2.34] +synonym: "UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity" RELATED [EC:2.4.2.34] +xref: EC:2.4.2.34 +xref: KEGG_REACTION:R04335 +xref: MetaCyc:2.4.2.34-RXN +xref: RHEA:19505 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0052636 ! arabinosyltransferase activity + +[Term] +id: GO:0050410 +name: 3-oxolaurate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2)." [EC:4.1.1.56, RHEA:13385] +synonym: "3-oxododecanoate carboxy-lyase (2-undecanone-forming)" RELATED [EC:4.1.1.56] +synonym: "3-oxododecanoate carboxy-lyase activity" RELATED [EC:4.1.1.56] +synonym: "beta-ketoacyl decarboxylase activity" RELATED [EC:4.1.1.56] +synonym: "beta-ketolaurate decarboxylase activity" RELATED [EC:4.1.1.56] +xref: EC:4.1.1.56 +xref: KEGG_REACTION:R03747 +xref: MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN +xref: RHEA:13385 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050411 +name: agaritine gamma-glutamyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN] +synonym: "(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" RELATED [EC:2.3.2.9] +synonym: "(gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity" RELATED [EC:2.3.2.9] +synonym: "agaritine g-glutamyltransferase activity" EXACT [] +xref: EC:2.3.2.9 +xref: MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0050412 +name: cinnamate beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13437] +synonym: "cinnamate b-D-glucosyltransferase activity" EXACT [] +synonym: "cinnamate glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.177] +synonym: "UDPG:t-cinnamate glucosyltransferase activity" RELATED [EC:2.4.1.177] +synonym: "UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.177] +synonym: "uridine diphosphoglucose-cinnamate glucosyltransferase activity" RELATED [EC:2.4.1.177] +xref: EC:2.4.1.177 +xref: KEGG_REACTION:R02256 +xref: MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN +xref: RHEA:13437 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050413 +name: D-alanine 2-hydroxymethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10064] +synonym: "2-methylserine hydroxymethyltransferase activity" RELATED [EC:2.1.2.7] +synonym: "5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity" RELATED [EC:2.1.2.7] +synonym: "D-alanine hydroxymethyltransferase activity" EXACT [] +xref: EC:2.1.2.7 +xref: KEGG_REACTION:R01225 +xref: MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN +xref: RHEA:10064 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0050414 +name: formimidoylaspartate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN] +synonym: "formiminoaspartate deiminase activity" EXACT [] +synonym: "N-formimidoyl-L-aspartate iminohydrolase activity" RELATED [EC:3.5.3.5] +xref: EC:3.5.3.5 +xref: MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN +xref: RHEA:13661 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050415 +name: formimidoylglutamase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22492] +synonym: "formiminoglutamase activity" EXACT [] +synonym: "formiminoglutamate hydrolase activity" RELATED [EC:3.5.3.8] +synonym: "N-formimidoyl-L-glutamate formimidoylhydrolase activity" RELATED [EC:3.5.3.8] +synonym: "N-formimino-L-glutamate formiminohydrolase activity" RELATED [EC:3.5.3.8] +synonym: "N-formiminoglutamate hydrolase activity" RELATED [EC:3.5.3.8] +xref: EC:3.5.3.8 +xref: KEGG_REACTION:R02285 +xref: MetaCyc:FORMIMINOGLUTAMASE-RXN +xref: RHEA:22492 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050416 +name: formimidoylglutamate deiminase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN] +synonym: "formiminoglutamate deiminase activity" EXACT [] +synonym: "formiminoglutamic iminohydrolase activity" RELATED [EC:3.5.3.13] +synonym: "N-formimidoyl-L-glutamate iminohydrolase activity" RELATED [EC:3.5.3.13] +xref: EC:3.5.3.13 +xref: MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN +xref: RHEA:22832 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0050417 +name: glutamin-(asparagin-)ase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN] +synonym: "glutaminase-(asparagin-)ase activity" EXACT [] +synonym: "glutaminase-asparaginase activity" RELATED [EC:3.5.1.38] +synonym: "L-ASNase/L-GLNase activity" RELATED [EC:3.5.1.38] +synonym: "L-asparagine/L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.38] +synonym: "L-glutamine(L-asparagine) amidohydrolase activity" RELATED [EC:3.5.1.38] +xref: EC:3.5.1.38 +xref: MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050418 +name: hydroxylamine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN] +synonym: "ammonia:(acceptor) oxidoreductase activity" RELATED [EC:1.7.99.1] +synonym: "ammonia:acceptor oxidoreductase activity" RELATED [EC:1.7.99.1] +synonym: "hydroxylamine (acceptor) reductase activity" RELATED [EC:1.7.99.1] +xref: EC:1.7.99.1 +xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN +xref: RHEA:22052 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0050419 +name: hydroxymandelonitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN] +synonym: "(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)" RELATED [EC:4.1.2.11] +synonym: "(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity" RELATED [EC:4.1.2.11] +synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.11] +synonym: "sorghum hydroxynitrile lyase activity" RELATED [EC:4.1.2.11] +xref: EC:4.1.2.11 +xref: MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN +xref: RHEA:15977 +is_a: GO:0047606 ! hydroxynitrilase activity + +[Term] +id: GO:0050420 +name: maltose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN] +synonym: "alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating)" RELATED [EC:2.4.1.139] +xref: EC:2.4.1.139 +xref: MetaCyc:MALTOSE-SYNTHASE-RXN +xref: RHEA:22320 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050421 +name: nitrite reductase (NO-forming) activity +namespace: molecular_function +alt_id: GO:0016666 +def: "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN] +comment: Note that EC:1.7.99.3 was merged into this term. +synonym: "[nitrite reductase (cytochrome)]" RELATED [EC:1.7.2.1] +synonym: "cd-cytochrome nitrite reductase activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome c-551:O2, NO2+ oxidoreductase activity" RELATED [EC:1.7.2.1] +synonym: "cytochrome cd activity" NARROW [EC:1.7.2.1] +synonym: "cytochrome cd1 activity" NARROW [EC:1.7.2.1] +synonym: "methyl viologen-nitrite reductase activity" NARROW [EC:1.7.2.1] +synonym: "nitric-oxide:ferricytochrome-c oxidoreductase activity" RELATED [EC:1.7.2.1] +synonym: "nitrite reductase (cytochrome; NO-forming) activity" RELATED [EC:1.7.2.1] +synonym: "NO-forming nitrite reductase (cytochrome) activity" EXACT [] +synonym: "NO-forming nitrite reductase activity" EXACT [] +synonym: "Pseudomonas cytochrome oxidase activity" NARROW [EC:1.7.2.1] +xref: EC:1.7.2.1 +xref: MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN +xref: RHEA:15233 +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor +is_a: GO:0098809 ! nitrite reductase activity + +[Term] +id: GO:0050422 +name: strictosidine beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12917] +synonym: "strictosidine b-glucosidase activity" EXACT [] +synonym: "strictosidine beta-D-glucohydrolase activity" RELATED [EC:3.2.1.105] +xref: EC:3.2.1.105 +xref: KEGG_REACTION:R03820 +xref: MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN +xref: RHEA:12917 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0050423 +name: thiamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN] +synonym: "thiamin dehydrogenase activity" RELATED [EC:1.1.3.23] +synonym: "thiamin oxidase activity" EXACT [] +synonym: "thiamin:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.23] +synonym: "thiamine dehydrogenase activity" RELATED [EC:1.1.3.23] +synonym: "thiamine:oxygen 5-oxidoreductase activity" RELATED [EC:1.1.3.23] +xref: EC:1.1.3.23 +xref: MetaCyc:THIAMIN-OXIDASE-RXN +xref: RHEA:21280 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050424 +name: obsolete alanine carboxypeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "alanine carboxypeptidase activity" EXACT [] +synonym: "N-benzoyl-L-alanine-amidohydrolase activity" RELATED [EC:3.4.17.6] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0050425 +name: obsolete carboxypeptidase B activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxypeptidase B activity" EXACT [] +synonym: "pancreatic carboxypeptidase B" RELATED [EC:3.4.17.2] +synonym: "peptidyl-L-lysine [L-arginine]hydrolase activity" RELATED [EC:3.4.17.2] +synonym: "protaminase activity" RELATED [EC:3.4.17.2] +synonym: "tissue carboxypeptidase B" RELATED [EC:3.4.17.2] +is_obsolete: true +replaced_by: GO:0004181 + +[Term] +id: GO:0050426 +name: obsolete peptidyl-glycinamidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN] +comment: This term was made obsolete because it represents a gene product. +synonym: "carboxamidopeptidase activity" RELATED [EC:3.4.19.2] +synonym: "carboxyamidase activity" RELATED [EC:3.4.19.2] +synonym: "peptidyl amino acid amide hydrolase activity" RELATED [EC:3.4.19.2] +synonym: "peptidyl carboxy-amidase activity" RELATED [EC:3.4.19.2] +synonym: "peptidyl carboxyamidase activity" RELATED [EC:3.4.19.2] +synonym: "peptidyl-glycinamidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0008242 + +[Term] +id: GO:0050427 +name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732] +synonym: "3'-phosphoadenosine 5'-phosphosulfate metabolism" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolic process" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate metabolism" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate metabolic process" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate metabolism" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolic process" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate metabolism" EXACT [] +synonym: "PAPS metabolic process" EXACT [] +synonym: "PAPS metabolism" EXACT [] +synonym: "phosphoadenosine phosphosulfate metabolic process" EXACT [] +synonym: "phosphoadenosine phosphosulfate metabolism" EXACT [] +xref: MetaCyc:PWY-5340 +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0050428 +name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732] +synonym: "3'-phosphoadenosine 5'-phosphosulfate anabolism" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate biosynthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate formation" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulfate synthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthesis" EXACT [] +synonym: "3'-phosphoadenosine 5'-phosphosulphate biosynthetic process" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate biosynthesis" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate biosynthetic process" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthesis" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate biosynthetic process" EXACT [] +synonym: "PAPS biosynthesis" EXACT [] +synonym: "PAPS biosynthetic process" EXACT [] +synonym: "phosphoadenosine phosphosulfate biosynthesis" EXACT [] +synonym: "phosphoadenosine phosphosulfate biosynthetic process" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0050427 ! 3'-phosphoadenosine 5'-phosphosulfate metabolic process + +[Term] +id: GO:0050429 +name: calcium-dependent phospholipase C activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [EC:3.1.4.3] +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0050431 +name: transforming growth factor beta binding +namespace: molecular_function +def: "Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732] +synonym: "TGF-beta binding" EXACT [] +synonym: "TGFbeta binding" EXACT [] +synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] +synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] +is_a: GO:0019838 ! growth factor binding +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0050432 +name: catecholamine secretion +namespace: biological_process +def: "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef] +is_a: GO:0032940 ! secretion by cell +is_a: GO:0051937 ! catecholamine transport + +[Term] +id: GO:0050433 +name: regulation of catecholamine secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai] +is_a: GO:0051952 ! regulation of amine transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0050432 ! catecholamine secretion + +[Term] +id: GO:0050434 +name: positive regulation of viral transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai] +synonym: "activation of viral transcription" NARROW [] +synonym: "stimulation of viral transcription" NARROW [] +synonym: "up regulation of viral transcription" EXACT [] +synonym: "up-regulation of viral transcription" EXACT [] +synonym: "upregulation of viral transcription" EXACT [] +is_a: GO:0046782 ! regulation of viral transcription +is_a: GO:0048524 ! positive regulation of viral process +relationship: positively_regulates GO:0019083 ! viral transcription + +[Term] +id: GO:0050435 +name: amyloid-beta metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai] +synonym: "amyloid-beta metabolism" EXACT [] +synonym: "beta-amyloid metabolic process" EXACT [] +synonym: "beta-amyloid metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:0050436 +name: microfibril binding +namespace: molecular_function +def: "Binding to a microfibril, any small fibril occurring in biological material." [GOC:ai] +comment: See also the cellular component term 'microfibril ; GO:0001527'. +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050437 +name: (-)-endo-fenchol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20565] +synonym: "(-)-endo-fenchol cyclase activity" RELATED [EC:4.2.3.10] +synonym: "geranyl pyrophosphate:(-)-endo-fenchol cyclase activity" RELATED [EC:4.2.3.10] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]" RELATED [EC:4.2.3.10] +xref: EC:4.2.3.10 +xref: KEGG_REACTION:R02004 +xref: MetaCyc:4.2.3.10-RXN +xref: RHEA:20565 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050438 +name: 2-ethylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+)." [EC:2.3.3.6, RHEA:23040] +synonym: "(R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity" RELATED [EC:2.3.3.6] +synonym: "2-ethylmalate-3-hydroxybutanedioate synthase activity" RELATED [EC:2.3.3.6] +synonym: "acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" RELATED [EC:2.3.3.6] +synonym: "propylmalate synthase activity" RELATED [EC:2.3.3.6] +synonym: "propylmalic synthase activity" RELATED [EC:2.3.3.6] +xref: EC:2.3.3.6 +xref: KEGG_REACTION:R00998 +xref: MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN +xref: RHEA:23040 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050439 +name: 2-hydroxy-3-oxoadipate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2)." [EC:2.2.1.5, RHEA:14341] +synonym: "2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity" RELATED [EC:2.2.1.5] +synonym: "2-hydroxy-3-oxoadipate synthetase activity" RELATED [EC:2.2.1.5] +synonym: "2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)" RELATED [EC:2.2.1.5] +synonym: "alpha-ketoglutaric-glyoxylic carboligase activity" RELATED [EC:2.2.1.5] +synonym: "oxoglutarate: glyoxylate carboligase activity" RELATED [EC:2.2.1.5] +synonym: "oxoglutarate:glyoxylate carboligase activity" RELATED [EC:2.2.1.5] +xref: EC:2.2.1.5 +xref: KEGG_REACTION:R00474 +xref: MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN +xref: RHEA:14341 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0050440 +name: 2-methylcitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [EC:2.3.3.5, RHEA:23780] +synonym: "2-methylcitrate oxaloacetate-lyase activity" RELATED [EC:2.3.3.5] +synonym: "MCS activity" RELATED [EC:2.3.3.5] +synonym: "methylcitrate synthase activity" RELATED [EC:2.3.3.5] +synonym: "methylcitrate synthetase activity" RELATED [EC:2.3.3.5] +synonym: "propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming)" RELATED [EC:2.3.3.5] +xref: EC:2.3.3.5 +xref: KEGG_REACTION:R00931 +xref: MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN +xref: RHEA:23780 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050441 +name: 3-ethylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." [EC:2.3.3.7, RHEA:10500] +synonym: "2-ethyl-3-hydroxybutanedioate synthase activity" RELATED [EC:2.3.3.7] +synonym: "3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity" RELATED [EC:2.3.3.7] +synonym: "butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)" RELATED [EC:2.3.3.7] +xref: EC:2.3.3.7 +xref: KEGG_REACTION:R01180 +xref: MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN +xref: RHEA:10500 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050442 +name: 3-propylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)." [EC:2.3.3.12, RHEA:14457] +synonym: "3-(n-propyl)-malate synthase activity" RELATED [EC:2.3.3.12] +synonym: "3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity" RELATED [EC:2.3.3.12] +synonym: "beta-n-propylmalate synthase activity" RELATED [EC:2.3.3.12] +synonym: "N-propylmalate synthase activity" RELATED [EC:2.3.3.12] +synonym: "pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)" RELATED [EC:2.3.3.12] +xref: EC:2.3.3.12 +xref: KEGG_REACTION:R03040 +xref: MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN +xref: RHEA:14457 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050444 +name: obsolete aquacobalamin reductase (NADPH) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN] +comment: The term was obsoleted because it is not known to be catalyzed by any gene product. +synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) activity" RELATED [EC:1.16.1.5] +synonym: "aquacobalamin (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" RELATED [EC:1.16.1.5] +synonym: "cob(II)alamin:NADP+ oxidoreductase activity" RELATED [EC:1.16.1.5] +synonym: "NADPH-linked aquacobalamin reductase activity" RELATED [EC:1.16.1.5] +synonym: "NADPH2:aquacob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.5] +synonym: "NADPH:aquacob(III)alamin oxidoreductase activity" RELATED [EC:1.16.1.5] +xref: EC:1.16.1.5 +xref: MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN +xref: RHEA:20752 +is_obsolete: true + +[Term] +id: GO:0050445 +name: asparagusate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH." [RHEA:14881] +synonym: "3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity" RELATED [EC:1.8.1.11] +synonym: "asparagusate dehydrogenase activity" RELATED [EC:1.8.1.11] +synonym: "asparagusate reductase (NADH) activity" EXACT [] +synonym: "asparagusate reductase (NADH2)" RELATED [EC:1.8.1.11] +synonym: "asparagusic dehydrogenase activity" RELATED [EC:1.8.1.11] +synonym: "NADH2:asparagusate oxidoreductase activity" RELATED [EC:1.8.1.11] +synonym: "NADH:asparagusate oxidoreductase activity" RELATED [EC:1.8.1.11] +xref: EC:1.8.1.11 +xref: KEGG_REACTION:R03761 +xref: MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN +xref: RHEA:14881 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050446 +name: azobenzene reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN] +synonym: "azo reductase activity" BROAD [EC:1.7.1.6] +synonym: "azo-dye reductase activity" BROAD [EC:1.7.1.6] +synonym: "azoreductase activity" BROAD [EC:1.7.1.6] +synonym: "dibromopropylaminophenylazobenzoic azoreductase activity" RELATED [EC:1.7.1.6] +synonym: "dimethylaminobenzene reductase activity" RELATED [EC:1.7.1.6] +synonym: "methyl red azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.6] +synonym: "N,N-dimethyl-4-phenylazoaniline azoreductase activity" RELATED [EC:1.7.1.6] +synonym: "NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity" RELATED [EC:1.7.1.6] +synonym: "NADPH-dependent azoreductase activity" BROAD [EC:1.7.1.6] +synonym: "NADPH2-dependent azoreductase activity" RELATED [EC:1.7.1.6] +synonym: "NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity" RELATED [EC:1.7.1.6] +synonym: "NADPH:4-(dimethylamino)azobenzene oxidoreductase activity" RELATED [EC:1.7.1.6] +synonym: "NC-reductase activity" NARROW [EC:1.7.1.6] +synonym: "new coccine (NC)-reductase" RELATED [EC:1.7.1.6] +synonym: "New coccine (NC)-reductase activity" NARROW [EC:1.7.1.6] +synonym: "nicotinamide adenine dinucleotide (phosphate) azoreductase activity" RELATED [EC:1.7.1.6] +synonym: "orange I azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "orange II azoreductase activity" NARROW [EC:1.7.1.6] +synonym: "p-aminoazobenzene reductase activity" RELATED [EC:1.7.1.6] +synonym: "p-dimethylaminoazobenzene azoreductase activity" RELATED [EC:1.7.1.6] +xref: EC:1.7.1.6 +xref: MetaCyc:AZOBENZENE-REDUCTASE-RXN +xref: RHEA:16269 +xref: UM-BBD_reactionID:r0808 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050447 +name: zeatin 9-aminocarboxyethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+)." [EC:2.5.1.50, RHEA:17333] +synonym: "3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.50] +synonym: "beta-(9-cytokinin)-alanine synthase activity" EXACT [] +synonym: "beta-(9-cytokinin)alanine synthase activity" RELATED [EC:2.5.1.50] +synonym: "lupinate synthetase activity" RELATED [EC:2.5.1.50] +synonym: "lupinic acid synthase activity" RELATED [EC:2.5.1.50] +synonym: "lupinic acid synthetase activity" RELATED [EC:2.5.1.50] +synonym: "O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity" RELATED [EC:2.5.1.50] +synonym: "O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)" RELATED [EC:2.5.1.50] +synonym: "O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity" RELATED [EC:2.5.1.50] +xref: EC:2.5.1.50 +xref: KEGG_REACTION:R03133 +xref: MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN +xref: RHEA:17333 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050448 +name: beta-cyclopiazonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [RHEA:14525] +synonym: "b-cyclopiazonate dehydrogenase activity" EXACT [] +synonym: "beta-cyclopiazonate oxidocyclase activity" RELATED [EC:1.21.99.1] +synonym: "beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)" RELATED [EC:1.21.99.1] +synonym: "beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)" RELATED [EC:1.21.99.1] +synonym: "beta-cyclopiazonic oxidocyclase activity" RELATED [EC:1.21.99.1] +xref: EC:1.21.99.1 +xref: KEGG_REACTION:R04080 +xref: MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN +xref: RHEA:14525 +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0050449 +name: casbene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14901] +synonym: "casbene synthetase activity" RELATED [EC:4.2.3.8] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.8] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)" RELATED [EC:4.2.3.8] +xref: EC:4.2.3.8 +xref: KEGG_REACTION:R02064 +xref: MetaCyc:CASBENE-SYNTHASE-RXN +xref: RHEA:14901 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0050450 +name: citrate (Re)-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN] +synonym: "(R)-citrate synthase activity" RELATED [EC:2.3.3.3] +synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]" RELATED [EC:2.3.3.3] +synonym: "citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity" RELATED [EC:2.3.3.3] +synonym: "citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA]" RELATED [EC:2.3.3.3] +synonym: "Re-citrate-synthase activity" RELATED [EC:2.3.3.3] +xref: EC:2.3.3.3 +xref: MetaCyc:CITRATE-RE-SYNTHASE-RXN +is_a: GO:0036440 ! citrate synthase activity + +[Term] +id: GO:0050451 +name: CoA-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN] +synonym: "CoA-disulfide reductase (NAD(P)H) activity" RELATED [EC:1.8.1.14] +synonym: "CoA-disulfide reductase (NADH) activity" EXACT [] +synonym: "CoA-disulfide reductase (NADH2)" RELATED [EC:1.8.1.14] +synonym: "CoA-disulfide reductase [NAD(P)H]" RELATED [EC:1.8.1.14] +synonym: "CoA-disulphide reductase activity" EXACT [] +synonym: "CoA:NAD(P)+ oxidoreductase activity" RELATED [EC:1.8.1.14] +synonym: "CoA:NAD+ oxidoreductase activity" RELATED [EC:1.8.1.14] +synonym: "CoADR activity" RELATED [EC:1.8.1.14] +synonym: "coenzyme A disulfide reductase activity" RELATED [EC:1.8.1.14] +synonym: "NADH2:CoA-disulfide oxidoreductase activity" RELATED [EC:1.8.1.14] +synonym: "NADH:CoA-disulfide oxidoreductase activity" RELATED [EC:1.8.1.14] +xref: EC:1.8.1.14 +xref: MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN +xref: RHEA:14705 +is_a: GO:0015036 ! disulfide oxidoreductase activity +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050452 +name: CoA-glutathione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [RHEA:14617] +synonym: "CoA-glutathione reductase (NADPH) activity" EXACT [] +synonym: "coenzyme A disulfide-glutathione reductase activity" RELATED [EC:1.8.1.10] +synonym: "coenzyme A glutathione disulfide reductase activity" RELATED [EC:1.8.1.10] +synonym: "glutathione:NADP+ oxidoreductase (CoA-acylating)" RELATED [EC:1.8.1.10] +synonym: "NADPH-dependent coenzyme A-SS-glutathione reductase activity" RELATED [EC:1.8.1.10] +synonym: "NADPH2:CoA-glutathione oxidoreductase activity" RELATED [EC:1.8.1.10] +synonym: "NADPH:CoA-glutathione oxidoreductase activity" RELATED [EC:1.8.1.10] +xref: EC:1.8.1.10 +xref: MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN +xref: RHEA:14617 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050453 +name: cob(II)alamin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH." [RHEA:17481] +synonym: "B(12r) reductase activity" RELATED [EC:1.16.1.4] +synonym: "B12r reductase activity" RELATED [EC:1.16.1.4] +synonym: "cob(I)alamin:NAD+ oxidoreductase activity" RELATED [EC:1.16.1.4] +synonym: "NADH2:cob(II)alamin oxidoreductase activity" RELATED [EC:1.16.1.4] +synonym: "NADH:cob(II)alamin oxidoreductase activity" RELATED [EC:1.16.1.4] +synonym: "vitamin B(12r) reductase activity" RELATED [EC:1.16.1.4] +synonym: "vitamin B12 reductase activity" EXACT [] +synonym: "vitamin B12 reduction" RELATED [] +synonym: "vitamin B12r reductase activity" RELATED [EC:1.16.1.4] +xref: EC:1.16.1.4 +xref: KEGG_REACTION:R00099 +xref: MetaCyc:COBIIALAMIN-REDUCTASE-RXN +xref: Reactome:R-HSA-3149560 "Unknown reductase reduces cob(II)alamin to cob(I)alamin" +xref: RHEA:17481 +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0050454 +name: coenzyme F420 hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420." [EC:1.12.98.1, RHEA:23760] +synonym: "8-hydroxy-5-deazaflavin-reducing hydrogenase activity" RELATED [EC:1.12.98.1] +synonym: "coenzyme F420-dependent hydrogenase activity" RELATED [EC:1.12.98.1] +synonym: "F420-reducing hydrogenase activity" RELATED [EC:1.12.98.1] +synonym: "hydrogen:coenzyme F420 oxidoreductase activity" RELATED [EC:1.12.98.1] +xref: EC:1.12.98.1 +xref: KEGG_REACTION:R03025 +xref: MetaCyc:COENZYME-F420-HYDROGENASE-RXN +xref: RHEA:23760 +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0050455 +name: columbamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O." [EC:1.21.3.2, RHEA:23564] +synonym: "berberine synthase activity" RELATED [EC:1.21.3.2] +synonym: "columbamine:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.21.3.2] +xref: EC:1.21.3.2 +xref: KEGG_REACTION:R00044 +xref: MetaCyc:COLUMBAMINE-OXIDASE-RXN +xref: RHEA:23564 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0050456 +name: cystine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH." [EC:1.8.1.6, RHEA:20597] +synonym: "cystine reductase (NADH) activity" RELATED [EC:1.8.1.6] +synonym: "cystine reductase (NADH2)" RELATED [EC:1.8.1.6] +synonym: "L-cysteine:NAD+ oxidoreductase" RELATED [EC:1.8.1.6] +synonym: "NADH-dependent cystine reductase activity" RELATED [EC:1.8.1.6] +synonym: "NADH2:L-cystine oxidoreductase" RELATED [EC:1.8.1.6] +synonym: "NADH:L-cystine oxidoreductase activity" RELATED [EC:1.8.1.6] +xref: EC:1.8.1.6 +xref: KEGG_REACTION:R00892 +xref: MetaCyc:CYSTINE-REDUCTASE-NADH-RXN +xref: RHEA:20597 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050457 +name: decylcitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)." [EC:2.3.3.2, RHEA:16605] +synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity" RELATED [EC:2.3.3.2] +synonym: "(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)" RELATED [EC:2.3.3.2] +synonym: "2-decylcitrate synthase activity" RELATED [EC:2.3.3.2] +synonym: "dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" RELATED [EC:2.3.3.2] +xref: EC:2.3.3.2 +xref: KEGG_REACTION:R03735 +xref: MetaCyc:DECYLCITRATE-SYNTHASE-RXN +xref: RHEA:16605 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050458 +name: decylhomocitrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)." [EC:2.3.3.4, RHEA:10364] +synonym: "2-decylhomocitrate synthase activity" RELATED [EC:2.3.3.4] +synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity" RELATED [EC:2.3.3.4] +synonym: "3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)" RELATED [EC:2.3.3.4] +synonym: "dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)" RELATED [EC:2.3.3.4] +xref: EC:2.3.3.4 +xref: KEGG_REACTION:R03859 +xref: MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN +xref: RHEA:10364 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050459 +name: ethanolamine-phosphate phospho-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate." [EC:4.2.3.2, RHEA:17889] +synonym: "amino alcohol O-phosphate phospholyase activity" BROAD [EC:4.2.3.2] +synonym: "ethanolamine-phosphate phospho-lyase (deaminating)" RELATED [EC:4.2.3.2] +synonym: "ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming)" RELATED [EC:4.2.3.2] +synonym: "O-phosphoethanolamine-phospholyase activity" RELATED [EC:4.2.3.2] +synonym: "O-phosphorylethanol-amine phospho-lyase activity" RELATED [EC:4.2.3.2] +xref: EC:4.2.3.2 +xref: KEGG_REACTION:R00748 +xref: MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN +xref: Reactome:R-HSA-5696415 "PXLP-K278-ETNPPL tetramer hydrolyses PETA" +xref: RHEA:17889 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050460 +name: hydroxylamine reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN] +synonym: "ammonium dehydrogenase activity" RELATED [EC:1.7.1.10] +synonym: "ammonium:NAD+ oxidoreductase activity" RELATED [EC:1.7.1.10] +synonym: "hydroxylamine reductase (NADH2)" RELATED [EC:1.7.1.10] +synonym: "N-hydroxy amine reductase activity" RELATED [EC:1.7.1.10] +synonym: "NADH-hydroxylamine reductase activity" RELATED [EC:1.7.1.10] +synonym: "NADH2:hydroxylamine oxidoreductase activity" RELATED [EC:1.7.1.10] +synonym: "NADH:hydroxylamine oxidoreductase activity" RELATED [EC:1.7.1.10] +xref: EC:1.7.1.10 +xref: MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN +xref: RHEA:20581 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050461 +name: L-mimosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [EC:2.5.1.52, RHEA:12693] +synonym: "3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.52] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity" RELATED [EC:2.5.1.52] +synonym: "O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)" RELATED [EC:2.5.1.52] +synonym: "O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.52] +xref: EC:2.5.1.52 +xref: KEGG_REACTION:R04091 +xref: MetaCyc:RXN-7461 +xref: RHEA:12693 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050462 +name: N-acetylneuraminate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN] +synonym: "(NANA)condensing enzyme activity" RELATED [EC:2.5.1.56] +synonym: "N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity" RELATED [EC:2.5.1.56] +synonym: "N-acetylneuraminic acid synthase activity" RELATED [EC:2.5.1.56] +synonym: "NeuAc synthase activity" RELATED [EC:2.5.1.56] +synonym: "phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" RELATED [EC:2.5.1.56] +xref: EC:2.5.1.56 +xref: MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN +xref: RHEA:19273 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050463 +name: nitrate reductase [NAD(P)H] activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] +synonym: "assimilatory NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "assimilatory nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "NAD(P)H bispecific nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "NAD(P)H-nitrate reductase activity" RELATED [EC:1.7.1.2] +synonym: "NAD(P)H2:nitrate oxidoreductase activity" RELATED [EC:1.7.1.2] +synonym: "NAD(P)H:nitrate oxidoreductase activity" RELATED [EC:1.7.1.2] +synonym: "nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" RELATED [EC:1.7.1.2] +synonym: "nitrate reductase [NAD(P)H2]" RELATED [EC:1.7.1.2] +synonym: "nitrate reductase NAD(P)H activity" RELATED [EC:1.7.1.2] +synonym: "nitrite:NAD(P)+ oxidoreductase activity" RELATED [EC:1.7.1.2] +xref: EC:1.7.1.2 +is_a: GO:0008940 ! nitrate reductase activity +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050464 +name: nitrate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN] +synonym: "assimilatory NADPH-nitrate reductase activity" RELATED [EC:1.7.1.3] +synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.3] +synonym: "assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity" RELATED [EC:1.7.1.3] +synonym: "NADPH-nitrate reductase activity" RELATED [EC:1.7.1.3] +synonym: "NADPH:nitrate oxidoreductase activity" RELATED [EC:1.7.1.3] +synonym: "NADPH:nitrate reductase activity" RELATED [EC:1.7.1.3] +synonym: "nitrate reductase (NADPH(2)) activity" RELATED [EC:1.7.1.3] +synonym: "nitrate reductase (NADPH2)" RELATED [EC:1.7.1.3] +synonym: "nitrite:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.3] +synonym: "triphosphopyridine nucleotide-nitrate reductase activity" RELATED [EC:1.7.1.3] +xref: EC:1.7.1.3 +xref: MetaCyc:NITRATE-REDUCTASE-NADPH-RXN +xref: RHEA:19061 +is_a: GO:0050463 ! nitrate reductase [NAD(P)H] activity + +[Term] +id: GO:0050465 +name: nitroquinoline-N-oxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN] +synonym: "4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity" RELATED [EC:1.7.1.9] +synonym: "4-nitroquinoline 1-oxide reductase activity" RELATED [EC:1.7.1.9] +synonym: "4NQO reductase activity" RELATED [EC:1.7.1.9] +synonym: "NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity" RELATED [EC:1.7.1.9] +synonym: "NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity" RELATED [EC:1.7.1.9] +xref: EC:1.7.1.9 +xref: MetaCyc:1.7.1.9-RXN +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0050466 +name: obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors" EXACT [] +is_obsolete: true +consider: GO:0046992 + +[Term] +id: GO:0050467 +name: pentalenene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18081] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" RELATED [EC:4.2.3.7] +synonym: "2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming)" RELATED [EC:4.2.3.7] +synonym: "pentalenene synthetase activity" RELATED [EC:4.2.3.7] +xref: EC:4.2.3.7 +xref: KEGG_REACTION:R02305 +xref: MetaCyc:PENTALENENE-SYNTHASE-RXN +xref: RHEA:18081 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0050468 +name: reticuline oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+)." [EC:1.21.3.3, RHEA:19885] +synonym: "(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)" RELATED [EC:1.21.3.3] +synonym: "BBE" RELATED [EC:1.21.3.3] +synonym: "berberine bridge enzyme activity" RELATED [EC:1.21.3.3] +synonym: "berberine-bridge-forming enzyme activity" RELATED [EC:1.21.3.3] +synonym: "tetrahydroprotoberberine synthase activity" RELATED [EC:1.21.3.3] +xref: EC:1.21.3.3 +xref: KEGG_REACTION:R03831 +xref: MetaCyc:RETICULINE-OXIDASE-RXN +xref: RHEA:19885 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0050469 +name: sabinene-hydrate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19565] +synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)" RELATED [EC:4.2.3.11] +synonym: "sabinene hydrate cyclase activity" RELATED [EC:4.2.3.11] +xref: EC:4.2.3.11 +xref: KEGG_REACTION:R02006 +xref: MetaCyc:4.2.3.11-RXN +xref: RHEA:19565 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050470 +name: trimethylamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN] +synonym: "TMADh activity" RELATED [EC:1.5.8.2] +synonym: "trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating)" RELATED [EC:1.5.8.2] +xref: EC:1.5.8.2 +xref: MetaCyc:1.5.8.2-RXN +xref: RHEA:11864 +xref: UM-BBD_enzymeID:e0854 +is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor + +[Term] +id: GO:0050471 +name: uracilylalanine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [RHEA:11496] +synonym: "3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.53] +synonym: "isowillardiine synthase activity" RELATED [EC:2.5.1.53] +synonym: "O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity" RELATED [EC:2.5.1.53] +synonym: "O3-acetyl-L-serine acetate-lyase (adding uracil)" RELATED [EC:2.5.1.53] +synonym: "O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity" RELATED [EC:2.5.1.53] +synonym: "Willardiine synthase activity" RELATED [EC:2.5.1.53] +xref: EC:2.5.1.53 +xref: MetaCyc:URACILYLALANINE-SYNTHASE-RXN +xref: RHEA:11496 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050472 +name: zeatin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin." [EC:1.3.1.69, RHEA:12757] +synonym: "dihydrozeatin:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.69] +xref: EC:1.3.1.69 +xref: KEGG_REACTION:R05702 +xref: MetaCyc:ZEATIN-REDUCTASE-RXN +xref: RHEA:12757 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050473 +name: arachidonate 15-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33] +synonym: "15-lipoxygenase activity" RELATED [EC:1.13.11.33] +synonym: "arachidonate omega(6) lipoxygenase activity" RELATED [EC:1.13.11.33] +synonym: "arachidonate omega6 lipoxygenase activity" RELATED [EC:1.13.11.33] +synonym: "arachidonate:oxygen 15-oxidoreductase activity" RELATED [EC:1.13.11.33] +synonym: "linoleic acid omega6-lipoxygenase activity" RELATED [EC:1.13.11.33] +synonym: "omega6 lipoxygenase activity" RELATED [EC:1.13.11.33] +xref: EC:1.13.11.33 +xref: MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN +xref: Reactome:R-HSA-2161951 "Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2" +xref: Reactome:R-HSA-2162002 "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B" +xref: Reactome:R-HSA-9018907 "ALOX15 oxidises 18(R)-HEPE to 18(R)-RvE3" +xref: Reactome:R-HSA-9020261 "Ac-PTGS2 dimer oxidises DHA to 17(R)-Hp-DHA" +xref: Reactome:R-HSA-9020262 "ALOX15 dehydrogenates 17(R)-Hp-DHA to 17R(16)-epoxy-DHA" +xref: Reactome:R-HSA-9020275 "ALOX15 oxidises DHA to 17(S)-Hp-DHA" +xref: Reactome:R-HSA-9020610 "ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3" +xref: Reactome:R-HSA-9024872 "ALOX15 oxidises 17(S)-Hp-DHA to PDX" +xref: Reactome:R-HSA-9024881 "ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA" +xref: Reactome:R-HSA-9025152 "ALOX15 oxidises DPAn-6 to 17(S)-HDPAn-6 and 10(S),17(S)-diHDPAn-6" +xref: Reactome:R-HSA-9026003 "ALOX15 oxidises DPAn-3 to 17(S)-Hp-DPAn-3" +xref: Reactome:R-HSA-9027532 "PTGS2 dimer oxidises DHA to 13-HDHA" +xref: Reactome:R-HSA-9027607 "Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3" +xref: Reactome:R-HSA-9027627 "Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)" +xref: Reactome:R-HSA-9028255 "PTGS2 dimer oxidises EPA to PGH3" +xref: RHEA:16869 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050474 +name: (S)-norcoclaurine synthase activity +namespace: molecular_function +alt_id: GO:0050475 +def: "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78] +synonym: "(S)-norlaudanosoline synthase activity" RELATED [EC:4.2.1.78] +synonym: "4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine)" RELATED [EC:4.2.1.78] +synonym: "4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]" RELATED [EC:4.2.1.78] +xref: EC:4.2.1.78 +xref: MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN +xref: RHEA:16173 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050476 +name: acetylenedicarboxylate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate." [EC:4.1.1.78] +synonym: "acetylenedicarboxylate carboxy-lyase (pyruvate-forming)" RELATED [EC:4.1.1.78] +synonym: "acetylenedicarboxylate carboxy-lyase activity" RELATED [EC:4.1.1.78] +synonym: "acetylenedicarboxylate hydrase activity" RELATED [EC:4.1.1.78] +synonym: "acetylenedicarboxylate hydratase activity" RELATED [EC:4.1.1.78] +xref: EC:4.1.1.78 +xref: MetaCyc:4.1.1.78-RXN +xref: RHEA:17733 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050477 +name: acyl-lysine deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate." [EC:3.5.1.17] +synonym: "6-N-acyl-L-lysine amidohydrolase activity" RELATED [EC:3.5.1.17] +synonym: "epsilon-lysine acylase activity" RELATED [EC:3.5.1.17] +synonym: "N6-acyl-L-lysine amidohydrolase activity" RELATED [EC:3.5.1.17] +xref: EC:3.5.1.17 +xref: MetaCyc:ACYL-LYSINE-DEACYLASE-RXN +xref: RHEA:24548 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050478 +name: obsolete anthranilate 3-monooxygenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O(2) = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H(2)O." [GOC:curators] +comment: This term is slated for obsoletion; According to RHEA the activity does not exist. +synonym: "anthranilate 3-hydroxylase activity" EXACT [] +synonym: "anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" RELATED [] +synonym: "anthranilic acid hydroxylase activity" BROAD [] +is_obsolete: true + +[Term] +id: GO:0050479 +name: glyceryl-ether monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN] +synonym: "1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity" RELATED [EC:1.14.16.5] +synonym: "alkylglycerol monooxygenase activity" RELATED [EC:1.14.16.5] +synonym: "glyceryl ether oxygenase activity" RELATED [EC:1.14.16.5] +synonym: "glyceryl etherase activity" RELATED [EC:1.14.16.5] +synonym: "glyceryl-ether cleaving enzyme activity" RELATED [EC:1.14.16.5] +synonym: "O-alkylglycerol monooxygenase activity" RELATED [EC:1.14.16.5] +xref: EC:1.14.16.5 +xref: MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN +xref: Reactome:R-HSA-5696119 "AGMO cleaves alkylglycerol into fatty aldehyde and glycerol" +xref: RHEA:36255 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050480 +name: imidazolonepropionase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+)." [EC:3.5.2.7, RHEA:23660] +synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity" RELATED [EC:3.5.2.7] +synonym: "4(5)-imidazolone-5(4)-propionic acid hydrolase activity" RELATED [EC:3.5.2.7] +synonym: "imidazolone propionic acid hydrolase activity" RELATED [EC:3.5.2.7] +synonym: "imidazolone-5-propionate hydrolase activity" RELATED [EC:3.5.2.7] +xref: EC:3.5.2.7 +xref: KEGG_REACTION:R02288 +xref: MetaCyc:IMIDAZOLONEPROPIONASE-RXN +xref: RHEA:23660 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050481 +name: mandelate 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21716] +synonym: "(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" RELATED [EC:1.14.16.6] +synonym: "L-mandelate 4-hydroxylase activity" EXACT [] +synonym: "mandelic acid 4-hydroxylase activity" RELATED [EC:1.14.16.6] +xref: EC:1.14.16.6 +xref: KEGG_REACTION:R03794 +xref: MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN +xref: RHEA:21716 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050482 +name: arachidonic acid secretion +namespace: biological_process +def: "The controlled release of arachidonic acid from a cell or a tissue." [GOC:ai] +comment: This term should be used to annotate release of arachidonic acid from the cell. For the hydrolytic release of arachidonic acid from a phospholipid, consider instead annotating to 'phospholipase A2 activity ; GO:0004623'. +is_a: GO:0032309 ! icosanoid secretion +is_a: GO:1903963 ! arachidonate transport + +[Term] +id: GO:0050483 +name: IMP 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate." [GOC:ai] +synonym: "IMP 5' nucleotidase activity" EXACT [] +synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] +xref: MetaCyc:RXN-7607 +xref: RHEA:27718 +is_a: GO:0008253 ! 5'-nucleotidase activity + +[Term] +id: GO:0050484 +name: GMP 5'-nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate." [GOC:ai] +synonym: "GMP 5' nucleotidase activity" EXACT [] +synonym: "IMP-GMP specific 5'-nucleotidase activity" RELATED [] +xref: MetaCyc:RXN-7609 +xref: RHEA:27714 +is_a: GO:0008253 ! 5'-nucleotidase activity + +[Term] +id: GO:0050485 +name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai] +synonym: "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor" EXACT [] +xref: EC:1.21.4.- +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0050486 +name: intramolecular transferase activity, transferring hydroxy groups +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah] +xref: EC:5.4.4.- +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0050487 +name: sulfoacetaldehyde acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde." [EC:2.3.3.15, RHEA:24204] +comment: Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). +synonym: "acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)" RELATED [EC:2.3.3.15] +synonym: "sulphoacetaldehyde acetyltransferase activity" EXACT [] +xref: EC:2.3.3.15 +xref: KEGG_REACTION:R05651 +xref: MetaCyc:RXN-2364 +xref: RHEA:24204 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0050488 +name: ecdysteroid UDP-glucosyltransferase activity +namespace: molecular_function +alt_id: GO:0050489 +def: "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711] +synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" RELATED [] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050490 +name: 1,4-lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN] +synonym: "1,4-lactone hydroxyacylhydrolase activity" RELATED [EC:3.1.1.25] +synonym: "gamma-lactonase activity" RELATED [EC:3.1.1.25] +xref: EC:3.1.1.25 +xref: MetaCyc:14-LACTONASE-RXN +xref: RHEA:12745 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050491 +name: sulcatone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone." [EC:1.1.1.260, RHEA:24484] +synonym: "sulcatol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.260] +xref: EC:1.1.1.260 +xref: KEGG_REACTION:R05678 +xref: MetaCyc:1.1.1.260-RXN +xref: RHEA:24484 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050492 +name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN] +synonym: "sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity" RELATED [EC:1.1.1.261] +xref: EC:1.1.1.261 +xref: MetaCyc:1.1.1.261-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050493 +name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164] +synonym: "GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +synonym: "GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT [] +xref: RESID:AA0164 +is_a: GO:0006506 ! GPI anchor biosynthetic process +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0050494 +name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165] +synonym: "GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +synonym: "GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT [] +xref: RESID:AA0165 +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0042082 ! GSI anchor biosynthetic process + +[Term] +id: GO:0050495 +name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346] +synonym: "peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine" EXACT [] +synonym: "peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine" EXACT [] +xref: RESID:AA0346 +is_a: GO:0018201 ! peptidyl-glycine modification + +[Term] +id: GO:0050496 +name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine +namespace: biological_process +def: "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347] +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine" EXACT [] +synonym: "peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine" EXACT [] +xref: RESID:AA0340 +is_a: GO:0018199 ! peptidyl-glutamine modification + +[Term] +id: GO:0050497 +name: alkylthioltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai] +synonym: "transferase activity, transferring alkylthio groups" EXACT [] +xref: EC:2.8.4.- +is_a: GO:0016782 ! transferase activity, transferring sulphur-containing groups + +[Term] +id: GO:0050498 +name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah] +xref: EC:1.14.20.- +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050499 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah] +xref: EC:1.20.1.- +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050500 +name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN] +synonym: "beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity" EXACT [] +synonym: "beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" RELATED [EC:2.4.1.211] +synonym: "beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity" RELATED [EC:2.4.1.211] +xref: EC:2.4.1.211 +xref: MetaCyc:2.4.1.211-RXN +xref: RHEA:20285 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050501 +name: hyaluronan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN] +synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" RELATED [EC:2.4.1.212] +synonym: "alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity" RELATED [EC:2.4.1.212] +synonym: "HAS activity" BROAD [EC:2.4.1.212] +synonym: "seHAS" RELATED [EC:2.4.1.212] +synonym: "spHAS" RELATED [EC:2.4.1.212] +xref: EC:2.4.1.212 +xref: MetaCyc:2.4.1.212-RXN +xref: Reactome:R-HSA-2160851 "HAS1,2,3 mediate the polymerisation of HA" +xref: RHEA:12528 +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050502 +name: cis-zeatin O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP." [EC:2.4.1.215, RHEA:20681] +synonym: "cis-zeatin O-b-D-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.215] +synonym: "UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.215] +xref: EC:2.4.1.215 +xref: KEGG_REACTION:R07260 +xref: MetaCyc:RXN-4735 +xref: RHEA:20681 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050503 +name: trehalose 6-phosphate phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN] +synonym: "trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.216] +xref: EC:2.4.1.216 +xref: MetaCyc:2.4.1.216-RXN +xref: RHEA:20864 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0050504 +name: mannosyl-3-phosphoglycerate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)." [EC:2.4.1.217, RHEA:13537] +synonym: "GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.217] +synonym: "MPG synthase activity" RELATED [EC:2.4.1.217] +xref: EC:2.4.1.217 +xref: KEGG_REACTION:R05768 +xref: MetaCyc:2.4.1.217-RXN +xref: RHEA:13537 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050505 +name: hydroquinone glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12560] +synonym: "arbutin synthase activity" RELATED [EC:2.4.1.218] +synonym: "hydroquinone:O-glucosyltransferase activity" RELATED [EC:2.4.1.218] +synonym: "UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.218] +synonym: "UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.218] +xref: EC:2.4.1.218 +xref: KEGG_REACTION:R05769 +xref: MetaCyc:2.4.1.218-RXN +xref: RHEA:12560 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050506 +name: vomilenine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19385] +synonym: "UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219] +synonym: "UDPG:vomilenine 21-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219] +synonym: "UDPG:vomilenine 21beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.219] +synonym: "vomilenine-glucosyltransferase activity" RELATED [EC:2.4.1.219] +xref: EC:2.4.1.219 +xref: KEGG_REACTION:R05882 +xref: MetaCyc:2.4.1.219-RXN +xref: RHEA:19385 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050507 +name: indoxyl-UDPG glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP." [EC:2.4.1.220, RHEA:12004] +synonym: "indoxyl-UDPG-glucosyltransferase activity" RELATED [EC:2.4.1.220] +synonym: "UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.220] +xref: EC:2.4.1.220 +xref: KEGG_REACTION:R06048 +xref: MetaCyc:2.4.1.220-RXN +xref: RHEA:12004 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050508 +name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN] +synonym: "alpha-N-acetylglucosaminyltransferase II activity" RELATED [EC:2.4.1.224] +synonym: "glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity" EXACT [] +synonym: "glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.224] +synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" RELATED [EC:2.4.1.224] +xref: EC:2.4.1.224 +xref: MetaCyc:2.4.1.224-RXN +xref: Reactome:R-HSA-2022851 "EXT1:EXT2 transfer GlcNAc to the heparan chain" +xref: Reactome:R-HSA-2022919 "EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue" +xref: Reactome:R-HSA-3656254 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain" +xref: Reactome:R-HSA-3656261 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain" +xref: Reactome:R-HSA-9036283 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the terminal GlcA residue" +xref: Reactome:R-HSA-9036290 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to heparan" +xref: RHEA:16213 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0050509 +name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN] +synonym: "heparan glucuronyltransferase II activity" RELATED [EC:2.4.1.225] +synonym: "N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity" EXACT [] +synonym: "N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity" RELATED [EC:2.4.1.225] +synonym: "UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity" RELATED [EC:2.4.1.225] +xref: EC:2.4.1.225 +xref: MetaCyc:2.4.1.225-RXN +xref: Reactome:R-HSA-2022856 "EXT1:EXT2 transfers GlcNAc to heparan" +xref: Reactome:R-HSA-2076392 "EXT1:EXT2 transfers GlcA to heparan" +xref: Reactome:R-HSA-3656257 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan" +xref: Reactome:R-HSA-3656267 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" +xref: Reactome:R-HSA-9036285 "Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan" +xref: Reactome:R-HSA-9036289 "Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan" +xref: RHEA:20908 +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050510 +name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN] +synonym: "alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity" RELATED [EC:2.4.1.226] +synonym: "chondroitin glucuronyltransferase II activity" RELATED [EC:2.4.1.226] +synonym: "N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity" EXACT [] +xref: EC:2.4.1.226 +xref: MetaCyc:2.4.1.226-RXN +xref: Reactome:R-HSA-1971491 "CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin" +xref: Reactome:R-HSA-3595178 "Defective CHSY1 does not transfer GlcA to chondroitin" +xref: Reactome:R-HSA-9632034 "CHSY1 transfers GlcA to chondroitin" +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0050511 +name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN] +comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. +synonym: "MurG transferase activity" RELATED [EC:2.4.1.227] +synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity" RELATED [EC:2.4.1.227] +synonym: "UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity" RELATED [EC:2.4.1.227] +synonym: "undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity" RELATED [EC:2.4.1.227] +synonym: "undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity" EXACT [] +xref: EC:2.4.1.227 +xref: MetaCyc:RXN-8976 +xref: RHEA:23192 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0050512 +name: lactosylceramide 4-alpha-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN] +synonym: "Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity" RELATED [EC:2.4.1.228] +synonym: "Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity" RELATED [EC:2.4.1.228] +synonym: "globotriaosylceramide/CD77 synthase activity" NARROW [EC:2.4.1.228] +synonym: "histo-blood group P(k) UDP-galactose activity" NARROW [EC:2.4.1.228] +synonym: "histo-blood group Pk UDP-galactose" RELATED [EC:2.4.1.228] +synonym: "lactosylceramide 4-a-galactosyltransferase activity" EXACT [] +synonym: "UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity" RELATED [EC:2.4.1.228] +xref: EC:2.4.1.228 +xref: MetaCyc:2.4.1.228-RXN +xref: RHEA:11924 +is_a: GO:0035250 ! UDP-galactosyltransferase activity + +[Term] +id: GO:0050513 +name: glycoprotein 2-beta-D-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP." [EC:2.4.2.38, RHEA:10612] +synonym: "1,2-beta-xylosyltransferase activity" RELATED [EC:2.4.2.38] +synonym: "beta-1,2-xylosyltransferase activity" RELATED [EC:2.4.2.38] +synonym: "glycoprotein 2-b-D-xylosyltransferase activity" EXACT [] +xref: EC:2.4.2.38 +xref: KEGG_REACTION:R06016 +xref: MetaCyc:2.4.2.38-RXN +xref: RHEA:10612 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0050514 +name: homospermidine synthase (spermidine-specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN] +synonym: "spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming)" RELATED [EC:2.5.1.45] +xref: EC:2.5.1.45 +xref: MetaCyc:2.5.1.45-RXN +xref: RHEA:11236 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0050515 +name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity +namespace: molecular_function +alt_id: GO:0008698 +def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+)." [EC:2.7.1.148, RHEA:18437] +synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity" RELATED [EC:2.7.1.148] +synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity" EXACT [] +synonym: "ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity" RELATED [EC:2.7.1.148] +synonym: "CDP-ME kinase activity" RELATED [EC:2.7.1.148] +synonym: "CMK activity" RELATED [EC:2.7.1.148] +xref: EC:2.7.1.148 +xref: KEGG_REACTION:R05634 +xref: MetaCyc:2.7.1.148-RXN +xref: RHEA:18437 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0050516 +name: obsolete inositol polyphosphate multikinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN] +comment: This term was made obsolete because this activity is currently defined as catalyzing two sequential reactions based on a gene product. However, "inositol polyphosphate multikinase activity" in some organisms can catalyze additional reactions. In addition, the reactions listed in the definition can be catalyzed independently by other gene products. +synonym: "ArgRIII" RELATED [EC:2.7.1.151] +synonym: "AtIpk2-alpha activity" NARROW [EC:2.7.1.151] +synonym: "AtIpk2-beta activity" NARROW [EC:2.7.1.151] +synonym: "AtIpk2alpha" RELATED [EC:2.7.1.151] +synonym: "AtIpk2beta" RELATED [EC:2.7.1.151] +synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.151] +synonym: "inositol polyphosphate 6-/3-/5-kinase activity" RELATED [EC:2.7.1.151] +synonym: "inositol polyphosphate multikinase activity" EXACT [] +synonym: "inositol-polyphosphate multikinase activity" EXACT [] +synonym: "IP3/IP4 6-/3-kinase activity" RELATED [EC:2.7.1.151] +synonym: "IP3/IP4 dual-specificity 6-/3-kinase activity" RELATED [EC:2.7.1.151] +synonym: "IpK2 activity" RELATED [EC:2.7.1.151] +synonym: "IpmK" RELATED [EC:2.7.1.151] +xref: EC:2.7.1.151 +xref: MetaCyc:2.7.1.151-RXN +is_obsolete: true + +[Term] +id: GO:0050517 +name: obsolete inositol hexakisphosphate kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN] +comment: Note that this was EC:2.7.1.152. This term was made obsolete because this activity is currently defined as catalyzing two reactions based on a gene product. The reactions listed in the definition can be catalyzed independently by other gene products. +synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.4.21] +synonym: "ATP:1D-myo-inositol-hexakisphosphate phosphotransferase activity" RELATED [EC:2.7.4.21] +synonym: "inositol hexakisphosphate kinase activity" EXACT [] +synonym: "inositol-hexakisphosphate kinase activity" EXACT [] +xref: EC:2.7.4.21 +xref: MetaCyc:2.7.1.152-RXN +is_obsolete: true + +[Term] +id: GO:0050518 +name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity +namespace: molecular_function +alt_id: GO:0008699 +def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13429] +synonym: "4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity" RELATED [EC:2.7.7.60] +synonym: "4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity" EXACT [] +synonym: "CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity" EXACT [] +synonym: "MCT activity" RELATED [EC:2.7.7.60] +synonym: "MEP cytidylyltransferase activity" EXACT [] +xref: EC:2.7.7.60 +xref: KEGG_REACTION:R05633 +xref: MetaCyc:2.7.7.60-RXN +xref: RHEA:13429 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0050519 +name: holo-citrate lyase synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN] +synonym: "2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity" RELATED [EC:2.7.7.61] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity" RELATED [EC:2.7.7.61] +synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity" RELATED [EC:2.7.7.61] +synonym: "CitX" RELATED [EC:2.7.7.61] +synonym: "holo-ACP synthase activity" RELATED [EC:2.7.7.61] +xref: EC:2.7.7.61 +xref: MetaCyc:2.7.7.61-RXN +xref: RHEA:16333 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0050520 +name: phosphatidylcholine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)." [EC:2.7.8.24, RHEA:14597] +synonym: "CDP-diacylglycerol:choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24] +synonym: "CDP-diglyceride-choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24] +synonym: "CDPdiglyceride-choline O-phosphatidyltransferase activity" RELATED [EC:2.7.8.24] +synonym: "PC synthase activity" RELATED [EC:2.7.8.24] +xref: EC:2.7.8.24 +xref: KEGG_REACTION:R05794 +xref: MetaCyc:2.7.8.24-RXN +xref: RHEA:14597 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0050521 +name: alpha-glucan, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN] +synonym: "a-glucan, water dikinase activity" EXACT [] +synonym: "alpha-glucan,water dikinase activity" RELATED [EC:2.7.9.4] +synonym: "ATP:alpha-glucan, water phosphotransferase activity" RELATED [EC:2.7.9.4] +synonym: "GWD" RELATED [EC:2.7.9.4] +synonym: "starch-related R1 protein activity" RELATED [EC:2.7.9.4] +xref: EC:2.7.9.4 +xref: MetaCyc:2.7.9.4-RXN +xref: RHEA:11668 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0050522 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai] +xref: EC:1.20.98.- +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050523 +name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" EXACT [] +is_obsolete: true +consider: GO:0030613 + +[Term] +id: GO:0050524 +name: coenzyme-B sulfoethylthiotransferase activity +namespace: molecular_function +alt_id: GO:0018552 +def: "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12532] +synonym: "2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity" RELATED [EC:2.8.4.1] +synonym: "coenzyme-B sulphoethylthiotransferase activity" EXACT [] +synonym: "methyl coenzyme M reductase activity" RELATED [EC:2.8.4.1] +synonym: "methyl-coenzyme-M reductase activity" EXACT [] +synonym: "methyl-CoM reductase activity" RELATED [EC:2.8.4.1] +xref: EC:2.8.4.1 +xref: KEGG_REACTION:R04541 +xref: MetaCyc:METHYL-COM-HTP-RXN +xref: RHEA:12532 +xref: UM-BBD_reactionID:r0356 +is_a: GO:0050497 ! alkylthioltransferase activity + +[Term] +id: GO:0050525 +name: cutinase activity +namespace: molecular_function +def: "Catalysis of the reaction: cutin + H2O = cutin monomers." [EC:3.1.1.74, MetaCyc:3.1.1.74-RXN] +synonym: "cutin hydrolase activity" RELATED [EC:3.1.1.74] +xref: EC:3.1.1.74 +xref: MetaCyc:3.1.1.74-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050526 +name: poly(3-hydroxybutyrate) depolymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN] +synonym: "PHB depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.75] +synonym: "poly(3HB) depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly(HA(SCL)) depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly(HA) depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly(HASCL) depolymerase activity" RELATED [EC:3.1.1.75] +synonym: "poly[(R)-3-hydroxybutyrate] hydrolase activity" RELATED [EC:3.1.1.75] +synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.75] +xref: EC:3.1.1.75 +xref: MetaCyc:3.1.1.75-RXN +xref: RHEA:11248 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050527 +name: poly(3-hydroxyoctanoate) depolymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN] +synonym: "PHA depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "PHO depolymerase activity" RELATED [EC:3.1.1.76] +synonym: "poly((R)-3-hydroxyoctanoate) hydrolase activity" RELATED [EC:3.1.1.76] +synonym: "poly((R)-hydroxyalkanoic acid) depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "poly(3HO) depolymerase activity" RELATED [EC:3.1.1.76] +synonym: "poly(HA(MCL)) depolymerase activity" RELATED [EC:3.1.1.76] +synonym: "poly(HA) depolymerase activity" BROAD [EC:3.1.1.76] +synonym: "poly(HAMCL) depolymerase activity" RELATED [EC:3.1.1.76] +synonym: "poly[(R)-3-hydroxyoctanoate] hydrolase activity" RELATED [EC:3.1.1.76] +synonym: "poly[(R)-hydroxyalkanoic acid] depolymerase" BROAD [EC:3.1.1.76] +synonym: "poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity" RELATED [EC:3.1.1.76] +xref: EC:3.1.1.76 +xref: MetaCyc:3.1.1.76-RXN +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050528 +name: acyloxyacyl hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN] +xref: EC:3.1.1.77 +xref: MetaCyc:3.1.1.77-RXN +xref: RHEA:12032 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050529 +name: polyneuridine-aldehyde esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol." [EC:3.1.1.78, RHEA:17501] +synonym: "PNAE activity" RELATED [EC:3.1.1.78] +synonym: "polyneuridine aldehyde esterase activity" RELATED [EC:3.1.1.78] +synonym: "polyneuridine aldehyde hydrolase (decarboxylating)" RELATED [EC:3.1.1.78] +xref: EC:3.1.1.78 +xref: KEGG_REACTION:R05825 +xref: MetaCyc:3.1.1.78-RXN +xref: RHEA:17501 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0050530 +name: glucosylglycerol 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22652] +synonym: "2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.69] +synonym: "salt tolerance protein A" RELATED [EC:3.1.3.69] +synonym: "StpA" RELATED [EC:3.1.3.69] +xref: EC:3.1.3.69 +xref: KEGG_REACTION:R05791 +xref: MetaCyc:3.1.3.69-RXN +xref: RHEA:22652 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050531 +name: mannosyl-3-phosphoglycerate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19309] +synonym: "alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity" RELATED [EC:3.1.3.70] +xref: EC:3.1.3.70 +xref: KEGG_REACTION:R05790 +xref: MetaCyc:3.1.3.70-RXN +xref: RHEA:19309 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050532 +name: 2-phosphosulfolactate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23416] +synonym: "(2R)-phosphosulfolactate phosphohydrolase activity" RELATED [EC:3.1.3.71] +synonym: "(R)-2-phospho-3-sulfolactate phosphohydrolase activity" RELATED [EC:3.1.3.71] +synonym: "2-phosphosulpholactate phosphatase activity" EXACT [] +synonym: "ComB phosphatase activity" RELATED [EC:3.1.3.71] +xref: EC:3.1.3.71 +xref: KEGG_REACTION:R05789 +xref: MetaCyc:R229-RXN +xref: RHEA:23416 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050533 +name: 5-phytase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN] +synonym: "myo-inositol-hexakisphosphate 5-phosphohydrolase activity" RELATED [EC:3.1.3.72] +xref: EC:3.1.3.72 +xref: MetaCyc:3.1.3.72-RXN +xref: RHEA:13001 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0050534 +name: 3-deoxyoctulosonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN] +synonym: "3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity" RELATED [EC:3.2.1.144] +synonym: "alpha-Kdo-ase activity" RELATED [EC:3.2.1.144] +xref: EC:3.2.1.144 +xref: MetaCyc:3.2.1.144-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050535 +name: beta-primeverosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN] +synonym: "6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity" RELATED [EC:3.2.1.149] +synonym: "b-primeverosidase activity" EXACT [] +xref: EC:3.2.1.149 +xref: MetaCyc:3.2.1.149-RXN +xref: RHEA:24480 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0050536 +name: (S)-N-acetyl-1-phenylethylamine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23952] +synonym: "(S)-N-acetyl-1-phenylethylamine amidohydrolase activity" RELATED [EC:3.5.1.85] +synonym: "(S)-N-acetylphenylethylamine:H2O hydrolase activity" RELATED [EC:3.5.1.85] +xref: EC:3.5.1.85 +xref: KEGG_REACTION:R07301 +xref: MetaCyc:3.5.1.85-RXN +xref: RHEA:23952 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050537 +name: mandelamide amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+)." [EC:3.5.1.86, RHEA:22876] +synonym: "mandelamide hydrolase activity" RELATED [EC:3.5.1.86] +synonym: "Pseudomonas mandelamide hydrolase activity" RELATED [EC:3.5.1.86] +xref: EC:3.5.1.86 +xref: KEGG_REACTION:R05783 +xref: MetaCyc:3.5.1.86-RXN +xref: RHEA:22876 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050538 +name: N-carbamoyl-L-amino-acid hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN] +synonym: "L-carbamoylase activity" RELATED [EC:3.5.1.87] +synonym: "N-carbamoyl-L-amino acid amidohydrolase activity" RELATED [EC:3.5.1.87] +xref: EC:3.5.1.87 +xref: MetaCyc:3.5.1.87-RXN +xref: RHEA:17581 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050539 +name: maleimide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate." [EC:3.5.2.16, RHEA:24476] +synonym: "cyclic imide hydrolase activity" RELATED [EC:3.5.2.16] +synonym: "cyclic-imide amidohydrolase (decyclicizing)" RELATED [EC:3.5.2.16] +synonym: "cyclic-imide amidohydrolase (decyclizing)" RELATED [EC:3.5.2.16] +synonym: "imidase activity" BROAD [EC:3.5.2.16] +xref: EC:3.5.2.16 +xref: KEGG_REACTION:R05781 +xref: MetaCyc:3.5.2.16-RXN +xref: RHEA:24476 +is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides + +[Term] +id: GO:0050540 +name: 2-aminomuconate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+)." [EC:3.5.99.5, RHEA:20996] +synonym: "2-aminomuconate aminohydrolase activity" RELATED [EC:3.5.99.5] +xref: EC:3.5.99.5 +xref: KEGG_REACTION:R03887 +xref: MetaCyc:3.5.99.5-RXN +xref: RHEA:20996 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0050541 +name: beta,beta-carotene-9',10'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918] +synonym: "b,b-carotene-9',10'-dioxygenase activity" EXACT [] +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050542 +name: icosanoid binding +namespace: molecular_function +def: "Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732] +synonym: "eicosanoid binding" EXACT [] +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0050543 +name: icosatetraenoic acid binding +namespace: molecular_function +def: "Binding to icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732] +synonym: "eicosatetraenoic acid binding" EXACT [] +is_a: GO:0036041 ! long-chain fatty acid binding + +[Term] +id: GO:0050544 +name: arachidonic acid binding +namespace: molecular_function +def: "Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai] +synonym: "arachidonate binding" EXACT [] +is_a: GO:0043177 ! organic acid binding +is_a: GO:0050542 ! icosanoid binding +is_a: GO:0050543 ! icosatetraenoic acid binding + +[Term] +id: GO:0050545 +name: sulfopyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20948] +synonym: "sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)" RELATED [EC:4.1.1.79] +synonym: "sulfopyruvate carboxy-lyase activity" RELATED [EC:4.1.1.79] +synonym: "sulphopyruvate decarboxylase activity" EXACT [] +xref: EC:4.1.1.79 +xref: KEGG_REACTION:R05774 +xref: MetaCyc:R231-RXN +xref: RHEA:20948 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050546 +name: 4-hydroxyphenylpyruvate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2)." [EC:4.1.1.80, RHEA:18697] +synonym: "4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)" RELATED [EC:4.1.1.80] +synonym: "4-hydroxyphenylpyruvate carboxy-lyase activity" RELATED [EC:4.1.1.80] +xref: EC:4.1.1.80 +xref: KEGG_REACTION:R03341 +xref: MetaCyc:4.1.1.80-RXN +xref: RHEA:18697 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050547 +name: vanillin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin." [RHEA:18725] +synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)" RELATED [] +synonym: "3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)" RELATED [] +xref: EC:4.1.2.61 +xref: KEGG_REACTION:R05773 +xref: MetaCyc:4.1.2.41-RXN +xref: RHEA:18725 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0050548 +name: trans-feruloyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN] +synonym: "4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming)" RELATED [EC:4.2.1.101] +synonym: "trans-feruloyl-CoA hydro-lyase activity" RELATED [EC:4.2.1.101] +xref: EC:4.2.1.101 +xref: MetaCyc:4.2.1.101-RXN +xref: RHEA:14517 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050549 +name: cyclohexyl-isocyanide hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O." [EC:4.2.1.103, RHEA:18197] +synonym: "isonitrile hydratase activity" RELATED [EC:4.2.1.103] +synonym: "N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)" RELATED [EC:4.2.1.103] +synonym: "N-cyclohexylformamide hydro-lyase activity" RELATED [EC:4.2.1.103] +xref: EC:4.2.1.103 +xref: KEGG_REACTION:R05771 +xref: MetaCyc:4.2.1.103-RXN +xref: RHEA:18197 +xref: UM-BBD_reactionID:r1029 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0050550 +name: pinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN] +synonym: "(-)-(1S,5S)-pinene synthase activity" RELATED [EC:4.2.3.14] +synonym: "beta-geraniolene synthase activity" RELATED [EC:4.2.3.14] +synonym: "geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)" RELATED [EC:4.2.3.14] +synonym: "geranyldiphosphate diphosphate lyase (pinene forming)" RELATED [EC:4.2.3.14] +xref: EC:4.2.3.14 +xref: MetaCyc:4.2.3.14-RXN +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0050551 +name: myrcene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene." [EC:4.2.3.15, RHEA:16965] +synonym: "geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity" EXACT [] +xref: EC:4.2.3.15 +xref: KEGG_REACTION:R02009 +xref: MetaCyc:RXN-5110 +xref: RHEA:16965 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0050552 +name: (4S)-limonene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN] +synonym: "(-)-(4S)-limonene synthase activity" EXACT [] +synonym: "4S-(-)-limonene synthase activity" RELATED [EC:4.2.3.16] +synonym: "geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]" RELATED [EC:4.2.3.16] +synonym: "geranyldiphosphate diphosphate lyase (limonene forming)" RELATED [EC:4.2.3.16] +synonym: "geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming]" RELATED [EC:4.2.3.16] +xref: EC:4.2.3.16 +xref: MetaCyc:4.2.3.16-RXN +xref: RHEA:12869 +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0050553 +name: taxadiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20912] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)" RELATED [EC:4.2.3.17] +synonym: "geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)" RELATED [EC:4.2.3.17] +synonym: "taxa-4(5),11(12)-diene synthase activity" RELATED [EC:4.2.3.17] +xref: EC:4.2.3.17 +xref: KEGG_REACTION:R06305 +xref: MetaCyc:4.2.3.17-RXN +xref: RHEA:20912 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050554 +name: abietadiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13873] +synonym: "(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming)" RELATED [EC:4.2.3.18] +synonym: "abietadiene cyclase activity" RELATED [EC:4.2.3.18] +synonym: "copalyl-diphosphate diphosphate-lyase (cyclizing)" RELATED [EC:4.2.3.18] +xref: EC:4.2.3.18 +xref: KEGG_REACTION:R06301 +xref: MetaCyc:4.2.3.18-RXN +xref: RHEA:13873 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0050555 +name: 2-hydroxypropyl-CoM lyase activity +namespace: molecular_function +def: "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN] +synonym: "(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23] +synonym: "(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23] +synonym: "2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)" RELATED [EC:4.4.1.23] +synonym: "coenzyme M-epoxyalkane ligase activity" RELATED [EC:4.4.1.23] +synonym: "EaCoMT activity" RELATED [EC:4.4.1.23] +synonym: "epoxyalkane:2-mercaptoethanesulfonate transferase activity" RELATED [EC:4.4.1.23] +synonym: "epoxyalkane:coenzyme M transferase activity" RELATED [EC:4.4.1.23] +synonym: "epoxyalkane:CoM transferase activity" RELATED [EC:4.4.1.23] +synonym: "epoxyalkyl:CoM transferase activity" RELATED [EC:4.4.1.23] +synonym: "epoxypropane:coenzyme M transferase activity" RELATED [EC:4.4.1.23] +synonym: "epoxypropyl:CoM transferase activity" RELATED [EC:4.4.1.23] +xref: EC:4.4.1.23 +xref: MetaCyc:4.2.99.19-RXN +xref: RHEA:19421 +xref: UM-BBD_enzymeID:e0538 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0050556 +name: deacetylisoipecoside synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.3, RHEA:21756] +synonym: "deacetylisoipecoside dopamine-lyase (secologanin-forming)" RELATED [EC:4.3.3.3] +synonym: "deacetylisoipecoside dopamine-lyase activity" RELATED [EC:4.3.3.3] +xref: EC:4.3.3.3 +xref: KEGG_REACTION:R05750 +xref: MetaCyc:4.3.3.3-RXN +xref: RHEA:21756 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0050557 +name: deacetylipecoside synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.4, RHEA:12296] +synonym: "deacetylipecoside dopamine-lyase (secologanin-forming)" RELATED [EC:4.3.3.4] +synonym: "deacetylipecoside dopamine-lyase activity" RELATED [EC:4.3.3.4] +xref: EC:4.3.3.4 +xref: KEGG_REACTION:R05749 +xref: MetaCyc:4.3.3.4-RXN +xref: RHEA:12296 +is_a: GO:0016843 ! amine-lyase activity + +[Term] +id: GO:0050558 +name: maltose epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-maltose = beta-maltose." [EC:5.1.3.21, RHEA:21228] +synonym: "maltose 1-epimerase activity" RELATED [EC:5.1.3.21] +xref: EC:5.1.3.21 +xref: KEGG_REACTION:R07319 +xref: MetaCyc:5.1.3.21-RXN +xref: RHEA:21228 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0050559 +name: copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24316] +synonym: "(+)-copalyl-diphosphate lyase (decyclizing)" RELATED [EC:5.5.1.12] +synonym: "diterpene cyclase activity" BROAD [] +xref: EC:5.5.1.12 +xref: KEGG_REACTION:R06298 +xref: MetaCyc:RXN-4861 +xref: RHEA:24316 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0050560 +name: aspartate-tRNA(Asn) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN] +synonym: "aspartate-tRNAAsn ligase activity" EXACT [] +synonym: "L-aspartate:tRNAAsx ligase (AMP-forming)" RELATED [EC:6.1.1.23] +synonym: "nondiscriminating aspartyl-tRNA synthetase activity" RELATED [EC:6.1.1.23] +xref: EC:6.1.1.23 +xref: MetaCyc:6.1.1.23-RXN +xref: RHEA:18349 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050561 +name: glutamate-tRNA(Gln) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN] +synonym: "glutamate-tRNAGln ligase activity" EXACT [] +synonym: "L-glutamate:tRNAGlx ligase (AMP-forming)" RELATED [EC:6.1.1.24] +synonym: "nondiscriminating glutamyl-tRNA synthetase activity" RELATED [EC:6.1.1.24] +xref: EC:6.1.1.24 +xref: MetaCyc:6.1.1.24-RXN +xref: RHEA:18397 +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050562 +name: lysine-tRNA(Pyl) ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [MetaCyc:6.1.1.25-RXN] +synonym: "L-lysine:tRNAPyl ligase (AMP-forming)" EXACT [] +synonym: "lysine-tRNAPyl ligase activity" EXACT [] +xref: MetaCyc:6.1.1.25-RXN +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0050563 +name: trans-feruloyl-CoA synthase activity +namespace: molecular_function +alt_id: GO:0106287 +def: "Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate." [PMID:22649270] +synonym: "ferulate-CoA ligase activity" RELATED [] +synonym: "trans-ferulate:CoASH ligase (ATP-hydrolysing)" RELATED [EC:6.2.1.34] +synonym: "trans-feruloyl-CoA synthetase activity" RELATED [EC:6.2.1.34] +xref: EC:6.2.1.34 +xref: MetaCyc:6.2.1.34-RXN +xref: RHEA:19389 +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0050564 +name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+)." [EC:6.3.2.26, RHEA:23196] +synonym: "ACV synthetase activity" BROAD [EC:6.3.2.26] +synonym: "L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)" RELATED [EC:6.3.2.26] +synonym: "L-alpha-aminoadipyl-cysteinyl-valine synthetase activity" RELATED [EC:6.3.2.26] +synonym: "L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity" RELATED [EC:6.3.2.26] +xref: EC:6.3.2.26 +xref: KEGG_REACTION:R04870 +xref: MetaCyc:6.3.2.26-RXN +xref: RHEA:23196 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050565 +name: aerobactin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate." [RHEA:11760] +synonym: "citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)" EXACT [] +synonym: "citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming)" EXACT [] +xref: KEGG_REACTION:R04357 +xref: MetaCyc:6.3.2.27-RXN +xref: RHEA:11760 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0050566 +name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN] +synonym: "Asp-AdT activity" RELATED [EC:6.3.5.6] +synonym: "Asp-tRNA(Asn) amidotransferase activity" RELATED [EC:6.3.5.6] +synonym: "Asp-tRNAAsn amidotransferase activity" RELATED [EC:6.3.5.6] +synonym: "Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.6] +synonym: "asparaginyl-tRNA synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.6] +synonym: "aspartyl-tRNA(Asn) amidotransferase activity" RELATED [EC:6.3.5.6] +synonym: "aspartyl-tRNAAsn amidotransferase activity" RELATED [EC:6.3.5.6] +synonym: "aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.6] +xref: EC:6.3.5.6 +xref: MetaCyc:6.3.5.6-RXN +xref: RHEA:14513 +xref: Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing) +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0050567 +name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +alt_id: GO:0008264 +alt_id: GO:0017068 +def: "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN] +synonym: "Glu-AdT activity" RELATED [EC:6.3.5.-] +synonym: "Glu-tRNA(Gln) amidotransferase activity" RELATED [EC:6.3.5.-] +synonym: "Glu-tRNAGln amidotransferase activity" RELATED [EC:6.3.5.7] +synonym: "Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.7] +synonym: "glutaminyl-tRNA synthase (glutamine-hydrolysing)" RELATED [EC:6.3.5.7] +synonym: "glutamyl-tRNA(Gln) amidotransferase activity" RELATED [EC:6.3.5.-] +synonym: "glutamyl-tRNAGln amidotransferase activity" RELATED [EC:6.3.5.7] +synonym: "glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.7] +xref: EC:6.3.5.7 +xref: MetaCyc:6.3.5.7-RXN +xref: RHEA:17521 +xref: Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing) +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0050568 +name: protein-glutamine glutaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN] +synonym: "destabilase activity" RELATED [EC:3.5.1.44] +synonym: "glutaminyl-peptide glutaminase activity" RELATED [EC:3.5.1.44] +synonym: "glutaminylpeptide glutaminase activity" RELATED [EC:3.5.1.44] +synonym: "peptidoglutaminase II activity" RELATED [EC:3.5.1.44] +synonym: "peptidylglutaminase II" RELATED [EC:3.5.1.44] +synonym: "protein-L-glutamine amidohydrolase activity" RELATED [EC:3.5.1.44] +xref: EC:3.5.1.44 +xref: MetaCyc:CHEBDEAMID-RXN +xref: RHEA:16441 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0050569 +name: glycolaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH." [EC:1.2.1.21, RHEA:20001] +synonym: "glycol aldehyde dehydrogenase activity" RELATED [EC:1.2.1.21] +synonym: "glycolaldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.21] +xref: EC:1.2.1.21 +xref: KEGG_REACTION:R01333 +xref: MetaCyc:GLYCOLALD-DEHYDROG-RXN +xref: RHEA:20001 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0050570 +name: 4-hydroxythreonine-4-phosphate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, RHEA:32275] +synonym: "4-(phosphohydroxy)-L-threonine dehydrogenase activity" RELATED [EC:1.1.1.262] +synonym: "4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.262] +synonym: "L-threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262] +synonym: "NAD(+)-dependent threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262] +synonym: "NAD+-dependent threonine 4-phosphate dehydrogenase activity" RELATED [EC:1.1.1.262] +synonym: "PdxA" RELATED [EC:1.1.1.262] +xref: EC:1.1.1.262 +xref: MetaCyc:1.1.1.262-RXN +xref: RHEA:32275 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050571 +name: 1,5-anhydro-D-fructose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.263, RHEA:20665] +synonym: "1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.263] +synonym: "AF reductase activity" RELATED [EC:1.1.1.263] +xref: EC:1.1.1.263 +xref: KEGG_REACTION:R05682 +xref: MetaCyc:1.1.1.263-RXN +xref: RHEA:20665 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050572 +name: L-idonate 5-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN] +synonym: "L-idonate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.264] +xref: EC:1.1.1.264 +xref: MetaCyc:1.1.1.264-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050573 +name: dTDP-4-dehydro-6-deoxyglucose reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:36583] +synonym: "dTDP-4-keto-6-deoxyglucose reductase activity" RELATED [EC:1.1.1.266] +synonym: "dTDP-D-fucose:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.266] +xref: EC:1.1.1.266 +xref: KEGG_REACTION:R05687 +xref: MetaCyc:1.1.1.266-RXN +xref: RHEA:36583 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050574 +name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.268, RHEA:13249] +synonym: "2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" RELATED [EC:1.1.1.268] +synonym: "2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.268] +xref: EC:1.1.1.268 +xref: KEGG_REACTION:R05689 +xref: MetaCyc:1.1.1.268-RXN +xref: RHEA:13249 +xref: UM-BBD_reactionID:r0852 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050575 +name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.269, RHEA:21052] +synonym: "2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity" RELATED [EC:1.1.1.269] +synonym: "2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.269] +xref: EC:1.1.1.269 +xref: KEGG_REACTION:R05690 +xref: MetaCyc:1.1.1.269-RXN +xref: RHEA:21052 +xref: UM-BBD_reactionID:r0853 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050577 +name: GDP-L-fucose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN] +synonym: "GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity" RELATED [EC:1.1.1.271] +synonym: "GDP-fucose synthetase activity" RELATED [EC:1.1.1.271] +synonym: "GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)" RELATED [EC:1.1.1.271] +xref: EC:1.1.1.271 +xref: MetaCyc:1.1.1.271-RXN +xref: Reactome:R-HSA-6787642 "TSTA3 dimer reduces GDP-KDGal to GDP-Fuc" +xref: RHEA:18885 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050578 +name: (R)-2-hydroxyacid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN] +synonym: "(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.272] +synonym: "(R)-sulfolactate:NAD(P)(+) oxidoreductase activity" RELATED [EC:1.1.1.272] +synonym: "(R)-sulfolactate:NAD(P)+ oxidoreductase activity" RELATED [EC:1.1.1.272] +synonym: "L-sulfolactate dehydrogenase activity" RELATED [EC:1.1.1.272] +xref: EC:1.1.1.272 +xref: MetaCyc:1.1.1.272-RXN +xref: RHEA:35735 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050579 +name: vellosimine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20029] +synonym: "10-deoxysarpagine:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.273] +xref: EC:1.1.1.273 +xref: KEGG_REACTION:R05827 +xref: MetaCyc:1.1.1.273-RXN +xref: RHEA:20029 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050580 +name: 2,5-didehydrogluconate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN] +synonym: "2,5-diketo-D-gluconate reductase activity" RELATED [EC:1.1.1.274] +synonym: "2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity" RELATED [EC:1.1.1.274] +synonym: "YqhE reductase" RELATED [EC:1.1.1.274] +xref: EC:1.1.1.274 +xref: MetaCyc:1.1.1.274-RXN +xref: RHEA:23828 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050581 +name: D-mannitol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannitol + O2 = mannose + H2O2." [EC:1.1.3.40, MetaCyc:1.1.3.40-RXN] +synonym: "D-arabinitol oxidase activity" RELATED [EC:1.1.3.40] +synonym: "D-arabitol oxidase activity" RELATED [EC:1.1.3.40] +synonym: "mannitol oxidase activity" RELATED [EC:1.1.3.40] +synonym: "mannitol:oxygen oxidoreductase (cyclizing)" RELATED [EC:1.1.3.40] +xref: EC:1.1.3.40 +xref: MetaCyc:1.1.3.40-RXN +xref: RHEA:18513 +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050582 +name: xylitol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: xylitol + O2 = xylose + H2O2." [EC:1.1.3.41, MetaCyc:1.1.3.41-RXN] +synonym: "xylitol:oxygen oxidoreductase activity" RELATED [EC:1.1.3.41] +xref: EC:1.1.3.41 +xref: MetaCyc:1.1.3.41-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0050583 +name: hydrogen dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + H2 = NADPH + H+." [EC:1.12.1.3, MetaCyc:1.12.1.3-RXN] +synonym: "hydrogen:NADP+ oxidoreductase activity" RELATED [EC:1.12.1.3] +synonym: "NADP-linked hydrogenase activity" RELATED [EC:1.12.1.3] +synonym: "NADP-reducing hydrogenase activity" RELATED [EC:1.12.1.3] +xref: EC:1.12.1.3 +xref: MetaCyc:1.12.1.3-RXN +xref: RHEA:18637 +is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor + +[Term] +id: GO:0050584 +name: linoleate 11-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18993] +synonym: "linoleate dioxygenase activity" RELATED [EC:1.13.11.45] +synonym: "linoleate:oxygen 11S-oxidoreductase activity" RELATED [EC:1.13.11.45] +synonym: "manganese lipoxygenase activity" RELATED [EC:1.13.11.45] +xref: EC:1.13.11.45 +xref: KEGG_REACTION:R05718 +xref: MetaCyc:1.13.11.45-RXN +xref: RHEA:18993 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050585 +name: 4-hydroxymandelate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN] +synonym: "4-hydroxyphenylpyruvate dioxygenase II activity" NARROW [EC:1.13.11.46] +synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.13.11.46] +xref: EC:1.13.11.46 +xref: MetaCyc:1.13.11.46-RXN +xref: RHEA:21376 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050586 +name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21572] +synonym: "(1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" RELATED [EC:1.13.11.48] +synonym: "1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity" EXACT [] +synonym: "1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity" EXACT [] +synonym: "3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)" RELATED [EC:1.13.11.48] +synonym: "3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity" EXACT [] +xref: EC:1.13.11.48 +xref: KEGG_REACTION:R05720 +xref: MetaCyc:1.13.11.48-RXN +xref: RHEA:21572 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050587 +name: chlorite O2-lyase activity +namespace: molecular_function +alt_id: GO:0030065 +def: "Catalysis of the reaction: chloride + O(2) = chlorite." [EC:1.13.11.49, RHEA:21404] +synonym: "chloride:oxygen oxidoreductase activity" RELATED [EC:1.13.11.49] +synonym: "chlorite dismutase activity" RELATED [EC:1.13.11.49] +xref: EC:1.13.11.49 +xref: KEGG_REACTION:R05721 +xref: MetaCyc:1.13.11.49-RXN +xref: RHEA:21404 +xref: UM-BBD_reactionID:r0982 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0050588 +name: apo-beta-carotenoid-14',13'-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.11.67, RHEA:26023] +synonym: "8'-apo-beta-carotenol:O2 oxidoreductase activity" RELATED [EC:1.13.11.67] +synonym: "apo-b-carotenoid-14',13'-dioxygenase activity" EXACT [] +xref: EC:1.13.11.67 +xref: KEGG_REACTION:R08889 +xref: MetaCyc:1.13.12.12-RXN +xref: RHEA:26023 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0050589 +name: leucocyanidin oxygenase activity +namespace: molecular_function +alt_id: GO:0045432 +def: "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.20.4, MetaCyc:1.14.11.19-RXN] +synonym: "anthocyanidin synthase activity" RELATED [EC:1.14.20.4] +synonym: "leucoanthocyanidin dioxygenase activity" RELATED [EC:1.14.20.4] +synonym: "leucoanthocyanidin hydroxylase" RELATED [EC:1.14.20.4] +synonym: "leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity" RELATED [EC:1.14.20.4] +xref: EC:1.14.20.4 +xref: MetaCyc:RXN-602 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0050590 +name: desacetoxyvindoline 4-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN] +synonym: "D17H activity" RELATED [EC:1.14.11.20] +synonym: "deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" RELATED [EC:1.14.11.20] +synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity" RELATED [EC:1.14.11.20] +synonym: "desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)" RELATED [EC:1.14.11.20] +synonym: "desacetoxyvindoline-4-hydroxylase activity" RELATED [EC:1.14.11.20] +synonym: "desacetyoxyvindoline-17-hydroxylase activity" RELATED [EC:1.14.11.20] +xref: EC:1.14.11.20 +xref: KEGG_REACTION:R05857 +xref: MetaCyc:1.14.11.20-RXN +xref: RHEA:18973 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0050591 +name: quinine 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.14.55, RHEA:20149] +synonym: "nifedipine oxidase activity" RELATED [EC:1.14.14.55] +synonym: "quinine 3-hydroxylase activity" EXACT [] +synonym: "quinine,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.55] +xref: EC:1.14.14.55 +xref: KEGG_REACTION:R05727 +xref: MetaCyc:1.14.13.67-RXN +xref: RHEA:20149 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050592 +name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)." [EC:1.14.14.37, RHEA:18401] +synonym: "(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.37] +synonym: "4-hydroxybenzeneacetaldehyde oxime monooxygenase activity" RELATED [EC:1.14.14.37] +synonym: "4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity" RELATED [EC:1.14.14.37] +synonym: "CYP71E1 activity" NARROW [EC:1.14.14.37] +synonym: "cytochrome P450-II-dependent monooxygenase activity" NARROW [EC:1.14.14.37] +synonym: "cytochrome P450II-dependent monooxygenase activity" RELATED [EC:1.14.14.37] +synonym: "NADPH-cytochrome P450 reductase (CYP71E1)" RELATED [EC:1.14.14.37] +xref: EC:1.14.14.37 +xref: KEGG_REACTION:R05728 +xref: MetaCyc:1.14.13.68-RXN +xref: RHEA:18401 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050593 +name: N-methylcoclaurine 3'-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)." [EC:1.14.14.102, RHEA:16649] +synonym: "(S)-N-methylcoclaurine 3'-hydroxylase activity" RELATED [EC:1.14.14.102] +synonym: "(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)" RELATED [EC:1.14.14.102] +synonym: "cytochrome P450 80B1 activity" RELATED [EC:1.14.14.102] +synonym: "N-methylcoclaurine 3'-hydroxylase activity" EXACT [] +xref: EC:1.14.14.102 +xref: KEGG_REACTION:R05732 +xref: MetaCyc:1.14.13.71-RXN +xref: RHEA:16649 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050594 +name: tabersonine 16-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)." [EC:1.14.14.103, RHEA:14133] +synonym: "tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating)" RELATED [EC:1.14.14.103] +xref: EC:1.14.14.103 +xref: KEGG_REACTION:R05855 +xref: MetaCyc:1.14.13.73-RXN +xref: RHEA:14133 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050595 +name: 7-deoxyloganin 7-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN] +synonym: "7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" RELATED [EC:1.14.13.74] +xref: EC:1.14.13.74 +xref: MetaCyc:1.14.13.74-RXN +xref: RHEA:11452 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050596 +name: vinorine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine." [EC:1.14.14.104, RHEA:17257] +synonym: "vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating)" RELATED [EC:1.14.14.104] +xref: EC:1.14.14.104 +xref: KEGG_REACTION:R05877 +xref: MetaCyc:1.14.13.75-RXN +xref: RHEA:17257 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050597 +name: taxane 10-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)." [EC:1.14.14.105, RHEA:15241] +synonym: "5-alpha-taxadienol-10-beta-hydroxylase activity" RELATED [EC:1.14.14.105] +synonym: "taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating)" RELATED [EC:1.14.14.105] +synonym: "taxane 10b-hydroxylase activity" EXACT [] +synonym: "taxane 10beta-hydroxylase activity" RELATED [EC:1.14.14.105] +xref: EC:1.14.14.105 +xref: KEGG_REACTION:R06309 +xref: MetaCyc:1.14.13.76-RXN +xref: RHEA:15241 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050598 +name: taxane 13-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.14.106, RHEA:18949] +synonym: "taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)" RELATED [EC:1.14.14.106] +synonym: "taxane 13a-hydroxylase activity" EXACT [] +synonym: "taxane 13alpha-hydroxylase activity" RELATED [EC:1.14.14.106] +xref: EC:1.14.14.106 +xref: KEGG_REACTION:R06308 +xref: MetaCyc:1.14.13.77-RXN +xref: RHEA:18949 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0050599 +name: deacetoxycephalosporin-C synthase activity +namespace: molecular_function +alt_id: GO:0045441 +def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate." [EC:1.14.20.1, RHEA:20748] +synonym: "DAOC synthase activity" RELATED [EC:1.14.20.1] +synonym: "DAOCS activity" RELATED [EC:1.14.20.1] +synonym: "deacetoxycephalosporin C synthetase activity" EXACT [] +synonym: "expandase activity" EXACT [] +synonym: "penicillin N expandase activity" RELATED [EC:1.14.20.1] +synonym: "penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)" RELATED [EC:1.14.20.1] +xref: EC:1.14.20.1 +xref: KEGG_REACTION:R05301 +xref: MetaCyc:1.14.20.1-RXN +xref: RHEA:20748 +is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated + +[Term] +id: GO:0050600 +name: myristoyl-CoA 11-(E) desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [RHEA:46396] +synonym: "n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.19.24] +synonym: "n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]" RELATED [EC:1.14.99.31] +xref: EC:1.14.19.24 +xref: MetaCyc:1.14.99.31-RXN +xref: RHEA:46396 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0050601 +name: myristoyl-CoA 11-(Z) desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [RHEA:25852] +synonym: "delta(11) desaturase" BROAD [EC:1.14.19.5] +synonym: "delta(11)-fatty-acid desaturase" BROAD [EC:1.14.19.5] +synonym: "delta(11)-palmitoyl-CoA desaturase" BROAD [EC:1.14.19.5] +synonym: "fatty acid delta(11)-desaturase" BROAD [EC:1.14.19.5] +synonym: "Z/E11-desaturase" BROAD [EC:1.14.19.5] +xref: EC:1.14.19.5 +xref: MetaCyc:1.14.99.32-RXN +xref: RHEA:25852 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0050602 +name: monoprenyl isoflavone epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN] +synonym: "7-O-methylluteone,NADPH:O2 oxidoreductase activity" RELATED [EC:1.14.99.34] +synonym: "7-O-methylluteone:O2 oxidoreductase activity" RELATED [EC:1.14.99.34] +synonym: "monoprenyl isoflavone monooxygenase activity" RELATED [EC:1.14.99.34] +xref: EC:1.14.99.34 +xref: MetaCyc:1.14.99.34-RXN +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050603 +name: thiophene-2-carbonyl-CoA monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+)." [EC:1.14.99.35, RHEA:18929] +synonym: "thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" RELATED [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA dehydrogenase activity" RELATED [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA hydroxylase activity" RELATED [EC:1.14.99.35] +synonym: "thiophene-2-carboxyl-CoA monooxygenase activity" RELATED [EC:1.14.99.35] +xref: EC:1.14.99.35 +xref: KEGG_REACTION:R05742 +xref: MetaCyc:1.14.99.35-RXN +xref: RHEA:18929 +xref: UM-BBD_reactionID:r1235 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050604 +name: taxadiene 5-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." [RHEA:14049] +synonym: "taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)" RELATED [] +synonym: "taxadiene 5a-hydroxylase activity" EXACT [] +synonym: "taxadiene 5alpha-hydroxylase activity" RELATED [] +xref: EC:1.14.14.176 +xref: KEGG_REACTION:R06306 +xref: MetaCyc:1.14.99.37-RXN +xref: RHEA:14049 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0050605 +name: superoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN] +synonym: "desulfoferrodoxin activity" RELATED [EC:1.15.1.2] +synonym: "neelaredoxin activity" RELATED [EC:1.15.1.2] +synonym: "rubredoxin:superoxide oxidoreductase activity" RELATED [EC:1.15.1.2] +xref: EC:1.15.1.2 +xref: MetaCyc:1.15.1.2-RXN +xref: RHEA:21324 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor + +[Term] +id: GO:0050606 +name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH." [RHEA:29587] +synonym: "2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312] +synonym: "4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity" RELATED [EC:1.1.1.312] +synonym: "4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312] +synonym: "alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity" RELATED [EC:1.1.1.312] +xref: EC:1.1.1.312 +xref: KEGG_REACTION:R04279 +xref: MetaCyc:1.2.1.45-RXN +xref: RHEA:29587 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050607 +name: mycothiol-dependent formaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.1.1.306, MetaCyc:1.2.1.66-RXN] +synonym: "formaldehyde:NAD+ oxidoreductase (mycothiol-formylating)" EXACT [] +synonym: "NAD/factor-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.306] +xref: EC:1.1.1.306 +xref: MetaCyc:1.2.1.66-RXN +xref: RHEA:28502 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050608 +name: vanillin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate." [EC:1.2.1.67, RHEA:13309] +synonym: "vanillin:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.67] +xref: EC:1.2.1.67 +xref: KEGG_REACTION:R05699 +xref: MetaCyc:1.2.1.67-RXN +xref: RHEA:13309 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050609 +name: phosphonate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate." [EC:1.20.1.1, RHEA:13173] +synonym: "NAD-dependent phosphite dehydrogenas activity" RELATED [EC:1.20.1.1] +synonym: "NAD:phosphite oxidoreductase activity" RELATED [EC:1.20.1.1] +synonym: "phosphite dehydrogenase activity" RELATED [EC:1.20.1.1] +synonym: "phosphonate:NAD+ oxidoreductase activity" RELATED [EC:1.20.1.1] +xref: EC:1.20.1.1 +xref: KEGG_REACTION:R05746 +xref: MetaCyc:1.20.1.1-RXN +xref: RHEA:13173 +xref: UM-BBD_reactionID:r1055 +is_a: GO:0050499 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor + +[Term] +id: GO:0050610 +name: methylarsonate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid." [EC:1.20.4.2, RHEA:15969] +synonym: "glutathione:methylarsonate oxidoreductase activity" RELATED [EC:1.20.4.2] +synonym: "MMA(V) reductase activity" RELATED [EC:1.20.4.2] +xref: EC:1.20.4.2 +xref: KEGG_REACTION:R05748 +xref: MetaCyc:1.20.4.2-RXN +xref: Reactome:R-HSA-5696230 "GSTO1 dimer reduces methylarsonate to methylarsonite" +xref: RHEA:15969 +xref: UM-BBD_reactionID:r0837 +is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor + +[Term] +id: GO:0050611 +name: arsenate reductase (azurin) activity +namespace: molecular_function +alt_id: GO:0018691 +def: "Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate." [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN] +synonym: "arsenite oxidase activity" RELATED [EC:1.20.9.1] +synonym: "arsenite:azurin oxidoreductase activity" RELATED [EC:1.20.9.1] +xref: EC:1.20.9.1 +xref: MetaCyc:1.20.98.1-RXN +xref: RHEA:18701 +xref: UM-BBD_reactionID:r0634 +is_a: GO:0052882 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor + +[Term] +id: GO:0050612 +name: arsenate reductase (donor) activity +namespace: molecular_function +def: "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+)." [EC:1.20.99.1, RHEA:18449] +synonym: "arsenate:(acceptor) oxidoreductase activity" RELATED [EC:1.20.99.1] +synonym: "arsenate:acceptor oxidoreductase activity" RELATED [EC:1.20.99.1] +xref: EC:1.20.99.1 +xref: KEGG_REACTION:R05752 +xref: MetaCyc:1.20.99.1-RXN +xref: RHEA:18449 +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0050613 +name: delta14-sterol reductase activity +namespace: molecular_function +alt_id: GO:0000251 +def: "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN] +comment: Note that zymosterol is cholesta-8,24-dien-3-ol. +synonym: "4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity" RELATED [EC:1.3.1.70] +synonym: "C-14 sterol reductase activity" EXACT [] +synonym: "D14-sterol reductase activity" EXACT [] +synonym: "sterol C-14 reductase activity" EXACT [] +synonym: "sterol C14-reductase activity" RELATED [EC:1.3.1.70] +xref: EC:1.3.1.70 +xref: MetaCyc:1.3.1.70-RXN +xref: Reactome:R-HSA-194674 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]" +xref: Reactome:R-HSA-194698 "4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]" +xref: RHEA:18561 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050614 +name: delta24-sterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN] +synonym: "D24-sterol reductase activity" EXACT [] +synonym: "lanosterol Delta(24)-reductase activity" NARROW [EC:1.3.1.72] +synonym: "lanosterol delta24-reductase activity" RELATED [EC:1.3.1.72] +synonym: "sterol:NADP+ delta24-oxidoreductase activity" RELATED [EC:1.3.1.72] +xref: EC:1.3.1.72 +xref: MetaCyc:1.3.1.72-RXN +xref: Reactome:R-HSA-196417 "Reduction of desmosterol to cholesterol" +xref: Reactome:R-HSA-6807064 "DHCR24 reduces ZYMOL to ZYMSTNL" +xref: RHEA:13685 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050615 +name: 1,2-dihydrovomilenine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH." [EC:1.3.1.73, RHEA:12320] +synonym: "17-O-acetylnorajmaline:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.73] +xref: EC:1.3.1.73 +xref: KEGG_REACTION:R05879 +xref: MetaCyc:1.3.1.73-RXN +xref: RHEA:12320 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050616 +name: secologanin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.14.19.62, MetaCyc:1.3.3.9-RXN] +synonym: "loganin:oxygen oxidoreductase (ring-cleaving)" RELATED [EC:1.14.19.62] +xref: EC:1.14.19.62 +xref: MetaCyc:1.3.3.9-RXN +xref: RHEA:20585 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050617 +name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN] +synonym: "PebA" RELATED [EC:1.3.7.2] +xref: EC:1.3.7.2 +xref: MetaCyc:1.3.7.2-RXN +xref: RHEA:10168 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050618 +name: phycoerythrobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN] +synonym: "(3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.3] +synonym: "PebB" RELATED [EC:1.3.7.3] +xref: EC:1.3.7.3 +xref: MetaCyc:1.3.7.3-RXN +xref: RHEA:22092 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050619 +name: phytochromobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN] +synonym: "(3Z)-phytochromobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.4] +synonym: "HY2" RELATED [EC:1.3.7.4] +synonym: "P-Phi-B synthase activity" RELATED [EC:1.3.7.4] +synonym: "PFB synthase activity" RELATED [EC:1.3.7.4] +synonym: "phytochromobilin synthase activity" RELATED [EC:1.3.7.4] +synonym: "PPhiB synthase activity" RELATED [EC:1.3.7.4] +xref: EC:1.3.7.4 +xref: MetaCyc:1.3.7.4-RXN +xref: RHEA:16377 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050620 +name: phycocyanobilin:ferredoxin oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN] +synonym: "(3Z)-phycocyanobilin:ferredoxin oxidoreductase activity" RELATED [EC:1.3.7.5] +xref: EC:1.3.7.5 +xref: MetaCyc:1.3.7.5-RXN +xref: RHEA:15309 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0050621 +name: tryptophan alpha,beta-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+)." [EC:1.3.3.10, RHEA:19901] +comment: Note that this was EC:1.4.3.17. +synonym: "L-tryptophan 2',3'-oxidase activity" RELATED [EC:1.3.3.10] +synonym: "L-tryptophan alpha,beta-dehydrogenase activity" RELATED [EC:1.3.3.10] +synonym: "L-tryptophan:oxygen alpha,beta-oxidoreductase activity" RELATED [EC:1.3.3.10] +synonym: "tryptophan a,b-oxidase activity" EXACT [] +xref: EC:1.3.3.10 +xref: KEGG_REACTION:R05317 +xref: MetaCyc:1.4.3.17-RXN +xref: RHEA:19901 +is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor + +[Term] +id: GO:0050622 +name: glycine dehydrogenase (cyanide-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2." [EC:1.4.99.5, MetaCyc:1.4.99.5-RXN] +synonym: "glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)" RELATED [EC:1.4.99.5] +synonym: "HCN synthase activity" RELATED [EC:1.4.99.5] +synonym: "hydrogen cyanide synthase activity" RELATED [EC:1.4.99.5] +xref: EC:1.4.99.5 +xref: MetaCyc:1.4.99.5-RXN +xref: RHEA:15821 +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0050623 +name: berberine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH." [EC:1.5.1.31, RHEA:21268] +synonym: "(R)-canadine synthase activity" RELATED [EC:1.5.1.31] +synonym: "(R)-tetrahydroberberine:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.31] +xref: EC:1.5.1.31 +xref: KEGG_REACTION:R07169 +xref: MetaCyc:1.5.1.31-RXN +xref: RHEA:21268 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050624 +name: vomilenine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16409] +synonym: "1,2-dihydrovomilenine:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.32] +xref: EC:1.5.1.32 +xref: KEGG_REACTION:R05878 +xref: MetaCyc:1.5.1.32-RXN +xref: RHEA:16409 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0050625 +name: 2-hydroxy-1,4-benzoquinone reductase activity +namespace: molecular_function +alt_id: GO:0018540 +def: "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)." [EC:1.6.5.7, RHEA:12428] +synonym: "1,2,4-trihydroxybenzene:NAD oxidoreductase activity" RELATED [EC:1.6.5.7] +synonym: "1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity" RELATED [EC:1.6.5.7] +synonym: "2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity" RELATED [EC:1.6.5.7] +synonym: "hydroxybenzoquinone reductase activity" RELATED [EC:1.6.5.-] +synonym: "NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity" RELATED [EC:1.6.5.7] +xref: EC:1.6.5.7 +xref: KEGG_REACTION:R05399 +xref: MetaCyc:1.6.5.7-RXN +xref: RHEA:12428 +xref: UM-BBD_reactionID:r0667 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0050626 +name: trimethylamine-N-oxide reductase (cytochrome c) activity +namespace: molecular_function +def: "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN] +synonym: "TMAO reductase activity" RELATED [EC:1.7.2.3] +synonym: "TOR activity" RELATED [EC:1.7.2.3] +synonym: "trimethylamine:cytochrome c oxidoreductase activity" RELATED [EC:1.7.2.3] +xref: EC:1.7.2.3 +xref: MetaCyc:1.7.2.3-RXN +xref: RHEA:24236 +xref: Wikipedia:Trimethylamine_N-oxide_reductase +is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor + +[Term] +id: GO:0050627 +name: mycothione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN] +synonym: "mycothiol-disulfide reductase activity" RELATED [EC:1.8.1.15] +synonym: "mycothiol:NAD(P)+ oxidoreductase activity" RELATED [EC:1.8.1.15] +xref: EC:1.8.1.15 +xref: MetaCyc:1.8.1.15-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050628 +name: 2-oxopropyl-CoM reductase (carboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH." [EC:1.8.1.5, RHEA:16977] +synonym: "2-KPCC activity" RELATED [EC:1.8.1.5] +synonym: "2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)" RELATED [EC:1.8.1.5] +synonym: "NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity" RELATED [EC:1.8.1.5] +synonym: "NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity" RELATED [EC:1.8.1.5] +xref: EC:1.8.1.5 +xref: KEGG_REACTION:R05713 +xref: MetaCyc:1.8.1.5-RXN +xref: RHEA:16977 +xref: UM-BBD_reactionID:r0854 +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0050629 +name: tetrachloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.21.99.5, MetaCyc:1.97.1.8-RXN] +synonym: "acceptor:trichloroethene oxidoreductase (chlorinating)" RELATED [EC:1.97.1.8] +synonym: "tetrachloroethene reductase activity" RELATED [EC:1.21.99.5] +xref: EC:1.21.99.5 +xref: MetaCyc:1.97.1.8-RXN +xref: RHEA:20353 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050630 +name: (iso)eugenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN] +synonym: "isoeugenol O-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity" RELATED [EC:2.1.1.146] +xref: EC:2.1.1.146 +xref: MetaCyc:2.1.1.146-RXN +xref: RHEA:17081 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0050631 +name: corydaline synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+)." [EC:2.1.1.147, RHEA:14773] +synonym: "S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity" RELATED [EC:2.1.1.147] +xref: EC:2.1.1.147 +xref: KEGG_REACTION:R07241 +xref: MetaCyc:2.1.1.147-RXN +xref: RHEA:14773 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0050632 +name: propionyl-CoA C2-trimethyltridecanoyltransferase activity +namespace: molecular_function +alt_id: GO:0004770 +def: "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.176, RHEA:10408] +synonym: "3-oxopristanoyl-CoA hydrolase activity" RELATED [EC:2.3.1.176] +synonym: "3-oxopristanoyl-CoA thiolase activity" RELATED [EC:2.3.1.176] +synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity" RELATED [EC:2.3.1.176] +synonym: "4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity" RELATED [EC:2.3.1.176] +synonym: "oxopristanoyl-CoA thiolase activity" RELATED [EC:2.3.1.176] +synonym: "peroxisomal 3-oxoacyl coenzyme A thiolase" NARROW [EC:2.3.1.176] +synonym: "peroxisome sterol carrier protein thiolase" NARROW [EC:2.3.1.176] +synonym: "propionyl-CoA C(2)-trimethyltridecanoyltransferase activity" EXACT [] +synonym: "SCPx" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein" RELATED [EC:2.3.1.176] +synonym: "sterol carrier protein X-related thiolase activity" RELATED [] +xref: EC:2.3.1.176 +xref: KEGG_REACTION:R05330 +xref: MetaCyc:2.3.1.154-RXN +xref: Reactome:R-HSA-192341 "Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA" +xref: Reactome:R-HSA-193533 "Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA" +xref: Reactome:R-HSA-2066781 "Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)" +xref: Reactome:R-HSA-390224 "3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA" +xref: RHEA:10408 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050633 +name: acetyl-CoA C-myristoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN] +synonym: "3-oxopalmitoyl-CoA hydrolase activity" RELATED [EC:2.3.1.155] +synonym: "3-oxopalmitoyl-CoA-CoA acetyltransferase activity" RELATED [EC:2.3.1.155] +synonym: "myristoyl-CoA C-acetyltransferase activity" RELATED [EC:2.3.1.155] +synonym: "myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity" RELATED [EC:2.3.1.155] +xref: EC:2.3.1.155 +xref: MetaCyc:2.3.1.155-RXN +xref: RHEA:18161 +is_a: GO:0016408 ! C-acyltransferase activity +is_a: GO:0019107 ! myristoyltransferase activity + +[Term] +id: GO:0050634 +name: phloroisovalerophenone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN] +synonym: "3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity" RELATED [EC:2.3.1.156] +synonym: "isovaleryl-CoA:malonyl-CoA acyltransferase activity" RELATED [EC:2.3.1.156] +synonym: "valerophenone synthase activity" RELATED [EC:2.3.1.156] +xref: EC:2.3.1.156 +xref: MetaCyc:2.3.1.156-RXN +xref: RHEA:23572 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050635 +name: acridone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O." [EC:2.3.1.159, RHEA:22224] +synonym: "malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)" RELATED [EC:2.3.1.159] +xref: EC:2.3.1.159 +xref: KEGG_REACTION:R07250 +xref: MetaCyc:2.3.1.159-RXN +xref: RHEA:22224 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050636 +name: vinorine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24016] +synonym: "acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing)" RELATED [EC:2.3.1.160] +xref: EC:2.3.1.160 +xref: KEGG_REACTION:R05876 +xref: MetaCyc:2.3.1.160-RXN +xref: RHEA:24016 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050637 +name: lovastatin nonaketide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+)." [EC:2.3.1.161, RHEA:18565] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)" RELATED [EC:2.3.1.161] +xref: EC:2.3.1.161 +xref: KEGG_REACTION:R07251 +xref: MetaCyc:2.3.1.161-RXN +xref: RHEA:18565 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050638 +name: taxadien-5-alpha-ol O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22028] +synonym: "acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity" RELATED [EC:2.3.1.162] +synonym: "acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity" RELATED [EC:2.3.1.162] +synonym: "acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity" RELATED [EC:2.3.1.162] +synonym: "taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity" RELATED [EC:2.3.1.162] +synonym: "taxadien-5a-ol O-acetyltransferase activity" EXACT [] +synonym: "taxadien-5alpha-ol O-acetyltransferase activity" RELATED [EC:2.3.1.162] +synonym: "taxadienol acetyltransferase activity" RELATED [EC:2.3.1.162] +xref: EC:2.3.1.162 +xref: KEGG_REACTION:R06307 +xref: MetaCyc:2.3.1.162-RXN +xref: RHEA:22028 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050639 +name: 10-hydroxytaxane O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18837] +synonym: "acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity" RELATED [EC:2.3.1.163] +synonym: "acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity" RELATED [EC:2.3.1.163] +synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.163] +xref: EC:2.3.1.163 +xref: KEGG_REACTION:R07252 +xref: MetaCyc:2.3.1.163-RXN +xref: RHEA:18837 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050640 +name: isopenicillin-N N-acyltransferase activity +namespace: molecular_function +alt_id: GO:0042319 +alt_id: GO:0045440 +def: "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN] +synonym: "acyl-CoA:isopenicillin N N-acyltransferase activity" RELATED [EC:2.3.1.164] +synonym: "acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity" RELATED [EC:2.3.1.164] +synonym: "acyl-coenzyme A:isopenicillin N acyltransferase activity" RELATED [EC:2.3.1.164] +synonym: "isopenicillin N:acyl-CoA acyltransferase activity" RELATED [EC:2.3.1.164] +synonym: "isopenicillin-N acyltransferase activity" EXACT [] +xref: EC:2.3.1.164 +xref: MetaCyc:2.3.1.164-RXN +xref: RHEA:20720 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0050641 +name: 6-methylsalicylic acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+)." [EC:2.3.1.165, RHEA:12240] +synonym: "6-MSAS activity" RELATED [EC:2.3.1.165] +synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)" RELATED [EC:2.3.1.165] +synonym: "MSAS activity" RELATED [EC:2.3.1.165] +xref: EC:2.3.1.165 +xref: KEGG_REACTION:R07253 +xref: MetaCyc:2.3.1.165-RXN +xref: RHEA:12240 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050642 +name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [EC:2.3.1.166, RHEA:18741] +synonym: "2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity" RELATED [EC:2.3.1.166] +synonym: "2a-hydroxytaxane 2-O-benzoyltransferase activity" EXACT [] +synonym: "2alpha-hydroxytaxane 2-O-benzoyltransferase activity" RELATED [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity" RELATED [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity" RELATED [EC:2.3.1.166] +synonym: "benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity" RELATED [EC:2.3.1.166] +xref: EC:2.3.1.166 +xref: KEGG_REACTION:R06310 +xref: MetaCyc:2.3.1.166-RXN +xref: RHEA:18741 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050643 +name: 10-deacetylbaccatin III 10-O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20137] +synonym: "acetyl-CoA:taxan-10beta-ol O-acetyltransferase" BROAD [EC:2.3.1.167] +xref: EC:2.3.1.167 +xref: KEGG_REACTION:R06311 +xref: MetaCyc:2.3.1.167-RXN +xref: RHEA:20137 +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:0050644 +name: cis-p-coumarate glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP." [EC:2.4.1.209, RHEA:13129] +synonym: "UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity" RELATED [EC:2.4.1.209] +xref: EC:2.4.1.209 +xref: KEGG_REACTION:R05324 +xref: MetaCyc:2.4.1.209-RXN +xref: RHEA:13129 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050645 +name: limonoid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP." [EC:2.4.1.210] +synonym: "LGTase activity" RELATED [EC:2.4.1.210] +synonym: "limonoid UDP-glucosyltransferase activity" RELATED [EC:2.4.1.210] +synonym: "uridine diphosphoglucose-limonoid glucosyltransferase activity" RELATED [EC:2.4.1.210] +xref: EC:2.4.1.210 +xref: MetaCyc:2.4.1.210-RXN +xref: RHEA:11256 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0050646 +name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Binding to 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0050542 ! icosanoid binding + +[Term] +id: GO:0050647 +name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Binding to 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0050542 ! icosanoid binding +is_a: GO:1901567 ! fatty acid derivative binding + +[Term] +id: GO:0050648 +name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding +namespace: molecular_function +def: "Binding to 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai] +synonym: "5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding" EXACT [] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0050542 ! icosanoid binding +is_a: GO:1901567 ! fatty acid derivative binding + +[Term] +id: GO:0050649 +name: testosterone 6-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664] +synonym: "testosterone 6b-hydroxylase activity" EXACT [] +is_a: GO:0008395 ! steroid hydroxylase activity + +[Term] +id: GO:0050650 +name: chondroitin sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] +synonym: "chondroitin sulfate proteoglycan anabolism" EXACT [] +synonym: "chondroitin sulfate proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation" EXACT [] +synonym: "chondroitin sulfate proteoglycan synthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthetic process" EXACT [] +is_a: GO:0030166 ! proteoglycan biosynthetic process +is_a: GO:0050654 ! chondroitin sulfate proteoglycan metabolic process + +[Term] +id: GO:0050651 +name: dermatan sulfate proteoglycan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] +synonym: "chondroitin sulfate B proteoglycan biosynthesis" EXACT [] +synonym: "chondroitin sulfate B proteoglycan biosynthetic process" EXACT [] +synonym: "dermatan sulfate proteoglycan anabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan biosynthesis" EXACT [] +synonym: "dermatan sulfate proteoglycan formation" EXACT [] +synonym: "dermatan sulfate proteoglycan synthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthetic process" EXACT [] +is_a: GO:0030166 ! proteoglycan biosynthetic process +is_a: GO:0050655 ! dermatan sulfate proteoglycan metabolic process + +[Term] +id: GO:0050652 +name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602] +synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +synonym: "chondroitin sulfate B proteoglycan chain elongation" EXACT [] +synonym: "dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan chain elongation" EXACT [] +synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "dermatan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0050653 +name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process +namespace: biological_process +def: "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602] +synonym: "chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] +synonym: "chondroitin sulfate proteoglycan chain elongation" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] +synonym: "chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] +synonym: "chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process + +[Term] +id: GO:0050654 +name: chondroitin sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai] +synonym: "chondroitin sulfate proteoglycan metabolism" EXACT [] +synonym: "chondroitin sulphate proteoglycan metabolic process" EXACT [] +synonym: "chondroitin sulphate proteoglycan metabolism" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process + +[Term] +id: GO:0050655 +name: dermatan sulfate proteoglycan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai] +synonym: "chondroitin sulfate B proteoglycan metabolic process" EXACT [] +synonym: "chondroitin sulfate B proteoglycan metabolism" EXACT [] +synonym: "dermatan sulfate proteoglycan metabolism" EXACT [] +synonym: "dermatan sulphate proteoglycan metabolic process" EXACT [] +synonym: "dermatan sulphate proteoglycan metabolism" EXACT [] +is_a: GO:0006029 ! proteoglycan metabolic process + +[Term] +id: GO:0050656 +name: 3'-phosphoadenosine 5'-phosphosulfate binding +namespace: molecular_function +def: "Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai] +synonym: "3'-phosphoadenosine 5'-phosphosulphate binding" EXACT [] +synonym: "3'-phosphoadenylyl-sulfate binding" EXACT [] +synonym: "adenosine 3'-phosphate 5'-phosphosulfate binding" EXACT [] +synonym: "PAPS binding" EXACT [] +synonym: "phosphoadenosine phosphosulfate binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0050657 +name: nucleic acid transport +namespace: biological_process +def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] +is_a: GO:0015931 ! nucleobase-containing compound transport + +[Term] +id: GO:0050658 +name: RNA transport +namespace: biological_process +def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050657 ! nucleic acid transport +is_a: GO:0051236 ! establishment of RNA localization + +[Term] +id: GO:0050659 +name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33] +comment: Consider instead annotating to the individual reactions: 'chondroitin 6-sulfotransferase activity ; GO:0008459' and 'dermatan 6-sulfotransferase activity ; GO:0036443'. +synonym: "3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity" RELATED [EC:2.8.2.33] +synonym: "GalNAc4S-6ST" RELATED [EC:2.8.2.33] +synonym: "N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity" RELATED [EC:2.8.2.33] +xref: EC:2.8.2.33 +xref: KEGG_REACTION:R02181 +xref: KEGG_REACTION:R07288 +xref: MetaCyc:RXN-7953 +xref: MetaCyc:RXN-7954 +xref: Reactome:R-HSA-2018659 "Chondroitin 4-sulfate (C4S) can be further sulfated on position 6 by CHST15" +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050660 +name: flavin adenine dinucleotide binding +namespace: molecular_function +def: "Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [GOC:ai, GOC:imk, ISBN:0198506732] +synonym: "FAD or FADH2 binding" EXACT [] +synonym: "flavine-adenine dinucleotide binding" EXACT [] +is_a: GO:0000166 ! nucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0050661 +name: NADP binding +namespace: molecular_function +def: "Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai] +synonym: "NADP or NADPH binding" RELATED [GOC:mah] +synonym: "NADP+ or NADPH binding" RELATED [] +synonym: "nicotinamide adenine dinucleotide phosphate binding" EXACT [] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0050662 +name: obsolete coenzyme binding +namespace: molecular_function +def: "OBSOLETE. Binding to a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group binding interactions that are not all chemically related by the fact that they may be used as a coenzyme. +is_obsolete: true + +[Term] +id: GO:0050664 +name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] +synonym: "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor" RELATED [] +xref: EC:1.6.3.- +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0050665 +name: hydrogen peroxide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai] +synonym: "H2O2 biosynthetic process" EXACT [GOC:mah] +synonym: "hydrogen peroxide anabolism" EXACT [] +synonym: "hydrogen peroxide biosynthesis" EXACT [] +synonym: "hydrogen peroxide formation" EXACT [] +synonym: "hydrogen peroxide generation" EXACT [] +synonym: "hydrogen peroxide synthesis" EXACT [] +is_a: GO:0042743 ! hydrogen peroxide metabolic process +is_a: GO:0044249 ! cellular biosynthetic process +is_a: GO:1903409 ! reactive oxygen species biosynthetic process + +[Term] +id: GO:0050666 +name: regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai] +synonym: "regulation of Hcy metabolic process" EXACT [] +synonym: "regulation of Hcy metabolism" EXACT [] +synonym: "regulation of homocysteine metabolism" EXACT [] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +relationship: regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050667 +name: homocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732] +synonym: "Hcy metabolic process" EXACT [] +synonym: "Hcy metabolism" EXACT [] +synonym: "homocysteine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0050668 +name: positive regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] +synonym: "activation of homocysteine metabolic process" NARROW [] +synonym: "positive regulation of Hcy metabolic process" EXACT [] +synonym: "positive regulation of Hcy metabolism" EXACT [] +synonym: "positive regulation of homocysteine metabolism" EXACT [] +synonym: "stimulation of homocysteine metabolic process" NARROW [] +synonym: "up regulation of homocysteine metabolic process" EXACT [] +synonym: "up-regulation of homocysteine metabolic process" EXACT [] +synonym: "upregulation of homocysteine metabolic process" EXACT [] +is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:0050666 ! regulation of homocysteine metabolic process +relationship: positively_regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050669 +name: negative regulation of homocysteine metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai] +synonym: "down regulation of homocysteine metabolic process" EXACT [] +synonym: "down-regulation of homocysteine metabolic process" EXACT [] +synonym: "downregulation of homocysteine metabolic process" EXACT [] +synonym: "inhibition of homocysteine metabolic process" NARROW [] +synonym: "negative regulation of Hcy metabolic process" EXACT [] +synonym: "negative regulation of Hcy metabolism" EXACT [] +synonym: "negative regulation of homocysteine metabolism" EXACT [] +is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:0050666 ! regulation of homocysteine metabolic process +relationship: negatively_regulates GO:0050667 ! homocysteine metabolic process + +[Term] +id: GO:0050670 +name: regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte proliferation." [GOC:ai] +is_a: GO:0032944 ! regulation of mononuclear cell proliferation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050671 +name: positive regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of lymphocyte proliferation." [GOC:ai] +synonym: "activation of lymphocyte proliferation" NARROW [] +synonym: "stimulation of lymphocyte proliferation" NARROW [] +synonym: "up regulation of lymphocyte proliferation" EXACT [] +synonym: "up-regulation of lymphocyte proliferation" EXACT [] +synonym: "upregulation of lymphocyte proliferation" EXACT [] +is_a: GO:0032946 ! positive regulation of mononuclear cell proliferation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050672 +name: negative regulation of lymphocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai] +synonym: "down regulation of lymphocyte proliferation" EXACT [] +synonym: "down-regulation of lymphocyte proliferation" EXACT [] +synonym: "downregulation of lymphocyte proliferation" EXACT [] +synonym: "inhibition of lymphocyte proliferation" NARROW [] +is_a: GO:0032945 ! negative regulation of mononuclear cell proliferation +is_a: GO:0050670 ! regulation of lymphocyte proliferation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0046651 ! lymphocyte proliferation + +[Term] +id: GO:0050673 +name: epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0050674 +name: urothelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050675 +name: regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050676 +name: negative regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai] +synonym: "down regulation of urothelial cell proliferation" EXACT [] +synonym: "down-regulation of urothelial cell proliferation" EXACT [] +synonym: "downregulation of urothelial cell proliferation" EXACT [] +synonym: "inhibition of urothelial cell proliferation" NARROW [] +is_a: GO:0050675 ! regulation of urothelial cell proliferation +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050677 +name: positive regulation of urothelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai] +synonym: "activation of urothelial cell proliferation" NARROW [] +synonym: "stimulation of urothelial cell proliferation" NARROW [] +synonym: "up regulation of urothelial cell proliferation" EXACT [] +synonym: "up-regulation of urothelial cell proliferation" EXACT [] +synonym: "upregulation of urothelial cell proliferation" EXACT [] +is_a: GO:0050675 ! regulation of urothelial cell proliferation +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: positively_regulates GO:0050674 ! urothelial cell proliferation + +[Term] +id: GO:0050678 +name: regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050679 +name: positive regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai] +synonym: "activation of epithelial cell proliferation" NARROW [] +synonym: "stimulation of epithelial cell proliferation" NARROW [] +synonym: "up regulation of epithelial cell proliferation" EXACT [] +synonym: "up-regulation of epithelial cell proliferation" EXACT [] +synonym: "upregulation of epithelial cell proliferation" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: positively_regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050680 +name: negative regulation of epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai] +synonym: "down regulation of epithelial cell proliferation" EXACT [] +synonym: "down-regulation of epithelial cell proliferation" EXACT [] +synonym: "downregulation of epithelial cell proliferation" EXACT [] +synonym: "inhibition of epithelial cell proliferation" NARROW [] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: negatively_regulates GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0050681 +name: androgen receptor binding +namespace: molecular_function +def: "Binding to an androgen receptor." [GOC:ai] +synonym: "AR binding" EXACT [] +is_a: GO:0016922 ! nuclear receptor binding + +[Term] +id: GO:0050682 +name: AF-2 domain binding +namespace: molecular_function +def: "Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050683 +name: AF-1 domain binding +namespace: molecular_function +def: "Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050684 +name: regulation of mRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai] +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050685 +name: positive regulation of mRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai] +synonym: "activation of mRNA processing" NARROW [] +synonym: "stimulation of mRNA processing" NARROW [] +synonym: "up regulation of mRNA processing" EXACT [] +synonym: "up-regulation of mRNA processing" EXACT [] +synonym: "upregulation of mRNA processing" EXACT [] +is_a: GO:0050684 ! regulation of mRNA processing +is_a: GO:1903313 ! positive regulation of mRNA metabolic process +relationship: positively_regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050686 +name: negative regulation of mRNA processing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai] +synonym: "down regulation of mRNA processing" EXACT [] +synonym: "down-regulation of mRNA processing" EXACT [] +synonym: "downregulation of mRNA processing" EXACT [] +synonym: "inhibition of mRNA processing" NARROW [] +is_a: GO:0050684 ! regulation of mRNA processing +is_a: GO:1903312 ! negative regulation of mRNA metabolic process +relationship: negatively_regulates GO:0006397 ! mRNA processing + +[Term] +id: GO:0050687 +name: negative regulation of defense response to virus +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai] +synonym: "down regulation of antiviral response" EXACT [] +synonym: "down-regulation of antiviral response" EXACT [] +synonym: "downregulation of antiviral response" EXACT [] +synonym: "inhibition of antiviral response" NARROW [] +synonym: "negative regulation of antiviral response" EXACT [GOC:dph] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0050688 ! regulation of defense response to virus +relationship: negatively_regulates GO:0051607 ! defense response to virus + +[Term] +id: GO:0050688 +name: regulation of defense response to virus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai] +synonym: "regulation of antiviral response" EXACT [] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0051607 ! defense response to virus + +[Term] +id: GO:0050689 +name: negative regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of antiviral response by host" EXACT [] +synonym: "down-regulation of antiviral response by host" EXACT [] +synonym: "downregulation of antiviral response by host" EXACT [] +synonym: "inhibition of antiviral response by host" NARROW [] +synonym: "negative regulation by host of antiviral response" EXACT [] +synonym: "negative regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050687 ! negative regulation of defense response to virus +is_a: GO:0050691 ! regulation of defense response to virus by host + +[Term] +id: GO:0050690 +name: regulation of defense response to virus by virus +namespace: biological_process +def: "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph] +synonym: "regulation by virus of antiviral response" EXACT [] +synonym: "regulation of antiviral response by virus" EXACT [GOC:dph] +synonym: "viral regulation of antiviral response" EXACT [] +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0050691 +name: regulation of defense response to virus by host +namespace: biological_process +def: "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph] +synonym: "host regulation of antiviral response" EXACT [] +synonym: "regulation by host of antiviral response" EXACT [] +synonym: "regulation of antiviral response by host" RELATED [GOC:dph] +is_a: GO:0050688 ! regulation of defense response to virus + +[Term] +id: GO:0050692 +name: DNA binding domain binding +namespace: molecular_function +def: "Binding to a protein's DNA binding domain (DBD)." [PMID:9682036] +synonym: "DBD binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050693 +name: LBD domain binding +namespace: molecular_function +def: "Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036] +synonym: "ligand binding domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050694 +name: galactose 3-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829] +synonym: "Gal-3-O-sulfotransferase activity" EXACT [] +synonym: "galactose 3-O-sulphotransferase activity" EXACT [] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050695 +name: benzoylformate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN] +synonym: "benzoylformate carboxy-lyase (benzaldehyde-forming)" RELATED [EC:4.1.1.7] +synonym: "benzoylformate carboxy-lyase activity" RELATED [EC:4.1.1.7] +synonym: "phenylglyoxylate decarboxylase activity" EXACT [] +xref: EC:4.1.1.7 +xref: MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN +xref: RHEA:23368 +xref: UM-BBD_reactionID:r1049 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0050696 +name: trichloroethylene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai] +synonym: "trichloroethene catabolic process" EXACT [] +synonym: "trichloroethene catabolism" EXACT [] +synonym: "trichloroethylene breakdown" EXACT [] +synonym: "trichloroethylene catabolism" EXACT [] +synonym: "trichloroethylene degradation" EXACT [] +is_a: GO:0018979 ! trichloroethylene metabolic process +is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process + +[Term] +id: GO:0050697 +name: 1,1,2-trichloroethene reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271] +synonym: "1,1,2-trichloroethylene reductive dehalogenase activity" EXACT [] +synonym: "TCE-reductive dehalogenase activity" EXACT [] +xref: MetaCyc:TCEREDCHLOR-RXN +xref: UM-BBD_enzymeID:e0271 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050698 +name: proteoglycan sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai] +synonym: "proteoglycan sulfate transfer" RELATED [] +synonym: "proteoglycan sulphotransferase activity" EXACT [] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0050699 +name: WW domain binding +namespace: molecular_function +def: "Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050700 +name: CARD domain binding +namespace: molecular_function +def: "Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050708 +name: regulation of protein secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050709 +name: negative regulation of protein secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] +synonym: "down regulation of protein secretion" EXACT [] +synonym: "down-regulation of protein secretion" EXACT [] +synonym: "downregulation of protein secretion" EXACT [] +synonym: "inhibition of protein secretion" NARROW [] +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0051224 ! negative regulation of protein transport +is_a: GO:1903531 ! negative regulation of secretion by cell +relationship: negatively_regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050714 +name: positive regulation of protein secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai] +synonym: "activation of protein secretion" NARROW [] +synonym: "stimulation of protein secretion" NARROW [] +synonym: "up regulation of protein secretion" EXACT [] +synonym: "up-regulation of protein secretion" EXACT [] +synonym: "upregulation of protein secretion" EXACT [] +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0051222 ! positive regulation of protein transport +is_a: GO:1903532 ! positive regulation of secretion by cell +relationship: positively_regulates GO:0009306 ! protein secretion + +[Term] +id: GO:0050727 +name: regulation of inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050728 +name: negative regulation of inflammatory response +namespace: biological_process +alt_id: GO:0030236 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai] +synonym: "anti-inflammatory response" EXACT [] +synonym: "down regulation of inflammatory response" EXACT [] +synonym: "down-regulation of inflammatory response" EXACT [] +synonym: "downregulation of inflammatory response" EXACT [] +synonym: "inhibition of inflammatory response" NARROW [] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0050727 ! regulation of inflammatory response +relationship: negatively_regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050729 +name: positive regulation of inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai] +synonym: "activation of inflammatory response" NARROW [] +synonym: "stimulation of inflammatory response" NARROW [] +synonym: "up regulation of inflammatory response" EXACT [] +synonym: "up-regulation of inflammatory response" EXACT [] +synonym: "upregulation of inflammatory response" EXACT [] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0050727 ! regulation of inflammatory response +relationship: positively_regulates GO:0006954 ! inflammatory response + +[Term] +id: GO:0050730 +name: regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050731 +name: positive regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +synonym: "activation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "stimulation of peptidyl-tyrosine phosphorylation" NARROW [] +synonym: "up regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "up-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "upregulation of peptidyl-tyrosine phosphorylation" EXACT [] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: positively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050732 +name: negative regulation of peptidyl-tyrosine phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai] +synonym: "down regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "down-regulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "downregulation of peptidyl-tyrosine phosphorylation" EXACT [] +synonym: "inhibition of peptidyl-tyrosine phosphorylation" NARROW [] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0018108 ! peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0050733 +name: RS domain binding +namespace: molecular_function +def: "Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0050734 +name: hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule." [GOC:ai] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0050735 +name: N-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0016410 ! N-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0050736 +name: O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0016420 ! malonyltransferase activity + +[Term] +id: GO:0050737 +name: O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] +is_a: GO:0008374 ! O-acyltransferase activity +is_a: GO:0050734 ! hydroxycinnamoyltransferase activity + +[Term] +id: GO:0050738 +name: fructosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0050739 +name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium +namespace: biological_process +def: "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348] +xref: RESID:AA0348 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018211 ! peptidyl-tryptophan modification +is_a: GO:0018212 ! peptidyl-tyrosine modification + +[Term] +id: GO:0050740 +name: protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine +namespace: biological_process +def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine." [RESID:AA0349] +xref: RESID:AA0349 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050741 +name: protein-FMN linkage via O3-riboflavin phosphoryl-L-serine +namespace: biological_process +def: "The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine." [RESID:AA0350] +xref: RESID:AA0350 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050742 +name: protein-FMN linkage via S-(4a-FMN)-L-cysteine +namespace: biological_process +def: "The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine." [RESID:AA0351] +xref: RESID:AA0351 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050743 +name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine +namespace: biological_process +def: "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352] +xref: RESID:AA0352 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050744 +name: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine +namespace: biological_process +def: "The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine." [RESID:AA0353] +xref: RESID:AA0353 +is_a: GO:0018309 ! protein-FMN linkage + +[Term] +id: GO:0050745 +name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188] +xref: RESID:AA0188 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine + +[Term] +id: GO:0050746 +name: regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] +synonym: "regulation of lipoprotein metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050747 +name: positive regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] +synonym: "activation of lipoprotein metabolic process" NARROW [] +synonym: "positive regulation of lipoprotein metabolism" EXACT [] +synonym: "stimulation of lipoprotein metabolic process" NARROW [] +synonym: "up regulation of lipoprotein metabolic process" EXACT [] +synonym: "up-regulation of lipoprotein metabolic process" EXACT [] +synonym: "upregulation of lipoprotein metabolic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +relationship: positively_regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050748 +name: negative regulation of lipoprotein metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai] +synonym: "down regulation of lipoprotein metabolic process" EXACT [] +synonym: "down-regulation of lipoprotein metabolic process" EXACT [] +synonym: "downregulation of lipoprotein metabolic process" EXACT [] +synonym: "inhibition of lipoprotein metabolic process" NARROW [] +synonym: "negative regulation of lipoprotein metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +relationship: negatively_regulates GO:0042157 ! lipoprotein metabolic process + +[Term] +id: GO:0050749 +name: obsolete apolipoprotein E receptor binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively with an apolipoprotein E receptor." [GOC:ai] +comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). +synonym: "apolipoprotein E receptor binding" EXACT [] +is_obsolete: true +replaced_by: GO:0070326 + +[Term] +id: GO:0050750 +name: low-density lipoprotein particle receptor binding +namespace: molecular_function +def: "Binding to a low-density lipoprotein receptor." [GOC:ai] +synonym: "LDL receptor binding" EXACT [] +synonym: "low-density lipoprotein receptor binding" EXACT [GOC:dph] +is_a: GO:0070325 ! lipoprotein particle receptor binding + +[Term] +id: GO:0050757 +name: obsolete thymidylate synthase biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [GOC:curators] +comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term. +synonym: "thymidylate synthase anabolism" EXACT [] +synonym: "thymidylate synthase biosynthesis" EXACT [] +synonym: "thymidylate synthase formation" EXACT [] +synonym: "thymidylate synthase synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0050758 +name: obsolete regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'regulation of gene expression', 'regulation of transcription' or some signaling term. +synonym: "regulation of thymidylate synthase anabolism" EXACT [] +synonym: "regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "regulation of thymidylate synthase formation" EXACT [] +synonym: "regulation of thymidylate synthase synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0050759 +name: obsolete positive regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'positive regulation of gene expression', 'positive regulation of transcription' or some signaling term. +synonym: "activation of thymidylate synthase biosynthetic process" NARROW [] +synonym: "positive regulation of thymidylate synthase anabolism" EXACT [] +synonym: "positive regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "positive regulation of thymidylate synthase formation" EXACT [] +synonym: "positive regulation of thymidylate synthase synthesis" EXACT [] +synonym: "stimulation of thymidylate synthase biosynthetic process" NARROW [] +synonym: "up regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "up-regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "upregulation of thymidylate synthase biosynthetic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0050760 +name: obsolete negative regulation of thymidylate synthase biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai] +comment: This term was obsoleted because it represent a specific gene product. Consider annotating to 'negative regulation of gene expression', 'negative regulation of transcription' or some signaling term. +synonym: "down regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "down-regulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "downregulation of thymidylate synthase biosynthetic process" EXACT [] +synonym: "inhibition of thymidylate synthase biosynthetic process" NARROW [] +synonym: "negative regulation of thymidylate synthase anabolism" EXACT [] +synonym: "negative regulation of thymidylate synthase biosynthesis" EXACT [] +synonym: "negative regulation of thymidylate synthase formation" EXACT [] +synonym: "negative regulation of thymidylate synthase synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0050761 +name: depsipeptide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +subset: goslim_pir +synonym: "depsipeptide metabolism" EXACT [] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:0050762 +name: depsipeptide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +synonym: "depsipeptide breakdown" EXACT [] +synonym: "depsipeptide catabolism" EXACT [] +synonym: "depsipeptide degradation" EXACT [] +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0050761 ! depsipeptide metabolic process + +[Term] +id: GO:0050763 +name: depsipeptide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators] +synonym: "depsipeptide anabolism" EXACT [] +synonym: "depsipeptide biosynthesis" EXACT [] +synonym: "depsipeptide formation" EXACT [] +synonym: "depsipeptide synthesis" EXACT [] +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0050761 ! depsipeptide metabolic process + +[Term] +id: GO:0050764 +name: regulation of phagocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050765 +name: negative regulation of phagocytosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai] +synonym: "down regulation of phagocytosis" EXACT [] +synonym: "down-regulation of phagocytosis" EXACT [] +synonym: "downregulation of phagocytosis" EXACT [] +synonym: "inhibition of phagocytosis" NARROW [] +is_a: GO:0050764 ! regulation of phagocytosis +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050766 +name: positive regulation of phagocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phagocytosis." [GOC:ai] +synonym: "activation of phagocytosis" NARROW [] +synonym: "stimulation of phagocytosis" NARROW [] +synonym: "up regulation of phagocytosis" EXACT [] +synonym: "up-regulation of phagocytosis" EXACT [] +synonym: "upregulation of phagocytosis" EXACT [] +is_a: GO:0050764 ! regulation of phagocytosis +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0006909 ! phagocytosis + +[Term] +id: GO:0050767 +name: regulation of neurogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system." [GOC:ai] +is_a: GO:0051960 ! regulation of nervous system development +is_a: GO:0060284 ! regulation of cell development +relationship: part_of GO:0048699 ! generation of neurons +relationship: regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050768 +name: negative regulation of neurogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] +synonym: "down regulation of neurogenesis" EXACT [] +synonym: "down-regulation of neurogenesis" EXACT [] +synonym: "downregulation of neurogenesis" EXACT [] +synonym: "inhibition of neurogenesis" NARROW [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0050767 ! regulation of neurogenesis +is_a: GO:0051961 ! negative regulation of nervous system development +relationship: negatively_regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050769 +name: positive regulation of neurogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system." [GOC:ai] +synonym: "activation of neurogenesis" NARROW [] +synonym: "stimulation of neurogenesis" NARROW [] +synonym: "up regulation of neurogenesis" EXACT [] +synonym: "up-regulation of neurogenesis" EXACT [] +synonym: "upregulation of neurogenesis" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0050767 ! regulation of neurogenesis +is_a: GO:0051962 ! positive regulation of nervous system development +relationship: positively_regulates GO:0022008 ! neurogenesis + +[Term] +id: GO:0050770 +name: regulation of axonogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050771 +name: negative regulation of axonogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai] +synonym: "down regulation of axonogenesis" EXACT [] +synonym: "down-regulation of axonogenesis" EXACT [] +synonym: "downregulation of axonogenesis" EXACT [] +synonym: "inhibition of axonogenesis" NARROW [] +is_a: GO:0010977 ! negative regulation of neuron projection development +is_a: GO:0050768 ! negative regulation of neurogenesis +is_a: GO:0050770 ! regulation of axonogenesis +relationship: negatively_regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050772 +name: positive regulation of axonogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axonogenesis." [GOC:ai] +synonym: "activation of axonogenesis" NARROW [] +synonym: "stimulation of axonogenesis" NARROW [] +synonym: "up regulation of axonogenesis" EXACT [] +synonym: "up-regulation of axonogenesis" EXACT [] +synonym: "upregulation of axonogenesis" EXACT [] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0050769 ! positive regulation of neurogenesis +is_a: GO:0050770 ! regulation of axonogenesis +relationship: positively_regulates GO:0007409 ! axonogenesis + +[Term] +id: GO:0050773 +name: regulation of dendrite development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendrite development." [GOC:ai] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0016358 ! dendrite development + +[Term] +id: GO:0050774 +name: negative regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +synonym: "down regulation of dendrite morphogenesis" EXACT [] +synonym: "down-regulation of dendrite morphogenesis" EXACT [] +synonym: "downregulation of dendrite morphogenesis" EXACT [] +synonym: "inhibition of dendrite morphogenesis" NARROW [] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0048814 ! regulation of dendrite morphogenesis +is_a: GO:0050768 ! negative regulation of neurogenesis +relationship: negatively_regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0050775 +name: positive regulation of dendrite morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai] +synonym: "activation of dendrite morphogenesis" NARROW [] +synonym: "stimulation of dendrite morphogenesis" NARROW [] +synonym: "up regulation of dendrite morphogenesis" EXACT [] +synonym: "up-regulation of dendrite morphogenesis" EXACT [] +synonym: "upregulation of dendrite morphogenesis" EXACT [] +is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0048814 ! regulation of dendrite morphogenesis +is_a: GO:0050769 ! positive regulation of neurogenesis +relationship: positively_regulates GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0050776 +name: regulation of immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0006955 ! immune response + +[Term] +id: GO:0050777 +name: negative regulation of immune response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +synonym: "down regulation of immune response" EXACT [] +synonym: "down-regulation of immune response" EXACT [] +synonym: "downregulation of immune response" EXACT [] +synonym: "inhibition of immune response" NARROW [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0050776 ! regulation of immune response +relationship: negatively_regulates GO:0006955 ! immune response + +[Term] +id: GO:0050778 +name: positive regulation of immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai] +synonym: "stimulation of immune response" NARROW [] +synonym: "up regulation of immune response" EXACT [] +synonym: "up-regulation of immune response" EXACT [] +synonym: "upregulation of immune response" EXACT [] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0050776 ! regulation of immune response +relationship: positively_regulates GO:0006955 ! immune response + +[Term] +id: GO:0050779 +name: RNA destabilization +namespace: biological_process +def: "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0043487 ! regulation of RNA stability +is_a: GO:0051254 ! positive regulation of RNA metabolic process +relationship: positively_regulates GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0050780 +name: dopamine receptor binding +namespace: molecular_function +def: "Binding to a dopamine receptor." [GOC:ai] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0050781 +name: ortho-trichlorophenol reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029] +synonym: "2,4,6-TCP reductive dehalogenase activity" EXACT [] +synonym: "2,4,6-trichlorophenol reductive dehalogenase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0050782 +name: galactose uniporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6] +synonym: "galactose, glucose uniporter activity" BROAD [] +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0008516 ! hexose uniporter activity + +[Term] +id: GO:0050783 +name: cocaine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732] +synonym: "cocaine metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0046448 ! tropane alkaloid metabolic process + +[Term] +id: GO:0050784 +name: cocaine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732] +synonym: "cocaine breakdown" EXACT [] +synonym: "cocaine catabolism" EXACT [] +synonym: "cocaine degradation" EXACT [] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0050783 ! cocaine metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0050785 +name: advanced glycation end-product receptor activity +namespace: molecular_function +def: "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)] +synonym: "AGE receptor activity" EXACT [PMID:21590515] +synonym: "RAGE activity" EXACT [PMID:21590515] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0050786 +name: RAGE receptor binding +namespace: molecular_function +def: "Binding to a RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai] +synonym: "advanced glycation end-product receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0050787 +name: detoxification of mercury ion +namespace: biological_process +def: "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920] +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:0046689 ! response to mercury ion + +[Term] +id: GO:0050788 +name: sequestering of mercury +namespace: biological_process +def: "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920] +synonym: "mercuric ion (Hg2+) sequestering" EXACT [] +synonym: "mercuric ion (Hg2+) sequestration" EXACT [] +synonym: "mercury (Hg) ion sequestering" EXACT [] +synonym: "mercury (Hg) ion sequestration" EXACT [] +synonym: "mercury (Hg2+) ion retention" EXACT [] +synonym: "mercury (Hg2+) ion storage" EXACT [] +synonym: "retention of mercury (Hg2+) ion" EXACT [] +synonym: "sequestering of mercuric ion (Hg2+)" EXACT [] +synonym: "sequestering of mercury (Hg) ion" EXACT [] +synonym: "sequestration of mercuric ion (Hg2+)" EXACT [] +synonym: "sequestration of mercury (Hg) ion" EXACT [] +synonym: "storage of mercury (Hg2+) ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +relationship: part_of GO:0050787 ! detoxification of mercury ion + +[Term] +id: GO:0050789 +name: regulation of biological process +namespace: biological_process +alt_id: GO:0050791 +def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] +subset: gocheck_do_not_annotate +subset: goslim_aspergillus +subset: goslim_candida +subset: goslim_pir +synonym: "regulation of physiological process" EXACT [] +is_a: GO:0065007 ! biological regulation +relationship: regulates GO:0008150 ! biological_process + +[Term] +id: GO:0050790 +name: regulation of catalytic activity +namespace: biological_process +alt_id: GO:0048552 +def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] +subset: goslim_chembl +synonym: "regulation of enzyme activity" EXACT [] +synonym: "regulation of metalloenzyme activity" NARROW [] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0050792 +name: regulation of viral process +namespace: biological_process +def: "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb] +synonym: "regulation of viral reproduction" NARROW [GOC:bf, GOC:jl] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0016032 ! viral process + +[Term] +id: GO:0050793 +name: regulation of developmental process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0032502 ! developmental process + +[Term] +id: GO:0050794 +name: regulation of cellular process +namespace: biological_process +alt_id: GO:0051244 +def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] +subset: gocheck_do_not_annotate +synonym: "regulation of cellular physiological process" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0009987 ! cellular process + +[Term] +id: GO:0050795 +name: regulation of behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr] +synonym: "regulation of behaviour" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0007610 ! behavior + +[Term] +id: GO:0050796 +name: regulation of insulin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai] +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0030073 ! insulin secretion + +[Term] +id: GO:0050797 +name: thymidylate synthase (FAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148] +synonym: "5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity" RELATED [EC:2.1.1.148] +synonym: "FDTS activity" RELATED [EC:2.1.1.148] +synonym: "flavin dependent thymidylate synthase activity" RELATED [EC:2.1.1.148] +synonym: "Thy1 activity" EXACT [] +synonym: "ThyX activity" EXACT [] +xref: EC:2.1.1.148 +xref: KEGG_REACTION:R06613 +xref: MetaCyc:RXN-8850 +xref: RHEA:29043 +is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity + +[Term] +id: GO:0050798 +name: activated T cell proliferation +namespace: biological_process +def: "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph] +comment: Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells. +synonym: "activated T lymphocyte proliferation" EXACT [] +synonym: "activated T-cell proliferation" EXACT [] +synonym: "activated T-lymphocyte proliferation" EXACT [] +synonym: "proliferation of activated T cells" EXACT [GOC:mah] +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0050799 +name: cocaine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai] +synonym: "cocaine anabolism" EXACT [] +synonym: "cocaine biosynthesis" EXACT [] +synonym: "cocaine formation" EXACT [] +synonym: "cocaine synthesis" EXACT [] +is_a: GO:0009710 ! tropane alkaloid biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0050783 ! cocaine metabolic process + +[Term] +id: GO:0050800 +name: obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai] +comment: This term was made obsolete because it represents both process and function information. +synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" EXACT [] +is_obsolete: true +consider: GO:0003924 +consider: GO:0006810 + +[Term] +id: GO:0050801 +name: ion homeostasis +namespace: biological_process +alt_id: GO:2000021 +def: "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai] +synonym: "electrolyte homeostasis" RELATED [] +synonym: "negative regulation of crystal formation" RELATED [] +synonym: "regulation of ion homeostasis" RELATED [] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0050802 +name: circadian sleep/wake cycle, sleep +namespace: biological_process +def: "The part of the circadian sleep/wake cycle where the organism is asleep." [GOC:ai] +is_a: GO:0022410 ! circadian sleep/wake cycle process +is_a: GO:0030431 ! sleep + +[Term] +id: GO:0050803 +name: regulation of synapse structure or activity +namespace: biological_process +def: "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0050804 +name: modulation of chemical synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission." [GOC:ai] +subset: goslim_synapse +synonym: "modulation of synaptic transmission" BROAD [] +synonym: "regulation of chemical synaptic transmission" EXACT [] +synonym: "regulation of synaptic transmission" EXACT [] +is_a: GO:0099177 ! regulation of trans-synaptic signaling +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0050805 +name: negative regulation of synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] +synonym: "down regulation of synaptic transmission" EXACT [] +synonym: "down-regulation of synaptic transmission" EXACT [] +synonym: "downregulation of synaptic transmission" EXACT [] +synonym: "inhibition of synaptic transmission" NARROW [] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: negatively_regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0050806 +name: positive regulation of synaptic transmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai] +synonym: "activation of synaptic transmission" NARROW [] +synonym: "stimulation of synaptic transmission" NARROW [] +synonym: "up regulation of synaptic transmission" EXACT [] +synonym: "up-regulation of synaptic transmission" EXACT [] +synonym: "upregulation of synaptic transmission" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: positively_regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0050807 +name: regulation of synapse organization +namespace: biological_process +def: "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_synapse +synonym: "regulation of synapse organisation" EXACT [GOC:mah] +synonym: "regulation of synapse organization and biogenesis" RELATED [GOC:mah] +synonym: "regulation of synapse structure" EXACT [] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: part_of GO:0050803 ! regulation of synapse structure or activity +relationship: regulates GO:0050808 ! synapse organization + +[Term] +id: GO:0050808 +name: synapse organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr] +subset: goslim_drosophila +subset: goslim_synapse +synonym: "synapse development" RELATED [GOC:aruk] +synonym: "synapse morphogenesis" RELATED [GOC:BHF] +synonym: "synapse organisation" EXACT [] +synonym: "synapse organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0050809 +name: diazepam binding +namespace: molecular_function +def: "Binding to diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732] +synonym: "diazepam binding inhibitor activity" RELATED [] +synonym: "Valium binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0050810 +name: regulation of steroid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai] +synonym: "regulation of steroid anabolism" EXACT [] +synonym: "regulation of steroid biosynthesis" EXACT [] +synonym: "regulation of steroid formation" EXACT [] +synonym: "regulation of steroid synthesis" EXACT [] +synonym: "regulation of steroidogenesis" EXACT [] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006694 ! steroid biosynthetic process + +[Term] +id: GO:0050811 +name: GABA receptor binding +namespace: molecular_function +def: "Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai] +synonym: "4-aminobutanoate receptor binding" EXACT [] +synonym: "4-aminobutyrate receptor binding" EXACT [] +synonym: "diazepam binding inhibitor activity" RELATED [] +synonym: "gamma-aminobutyric acid receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0050812 +name: regulation of acyl-CoA biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai] +synonym: "regulation of acyl-CoA anabolism" EXACT [] +synonym: "regulation of acyl-CoA biosynthesis" EXACT [] +synonym: "regulation of acyl-CoA formation" EXACT [] +synonym: "regulation of acyl-CoA synthesis" EXACT [] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +relationship: regulates GO:0071616 ! acyl-CoA biosynthetic process + +[Term] +id: GO:0050813 +name: epothilone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [ISBN:0198506732] +synonym: "epothilone metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0033067 ! macrolide metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0050814 +name: epothilone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai] +synonym: "epothilone anabolism" EXACT [] +synonym: "epothilone biosynthesis" EXACT [] +synonym: "epothilone formation" EXACT [] +synonym: "epothilone synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0033068 ! macrolide biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0050813 ! epothilone metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0050815 +name: phosphoserine residue binding +namespace: molecular_function +def: "Binding to a phosphorylated serine residue within a protein." [GOC:ai] +synonym: "phosphoserine binding" RELATED [] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0050816 +name: phosphothreonine residue binding +namespace: molecular_function +def: "Binding to a phosphorylated threonine residue within a protein." [GOC:ai] +synonym: "phosphothreonine binding" RELATED [] +is_a: GO:0045309 ! protein phosphorylated amino acid binding + +[Term] +id: GO:0050817 +name: coagulation +namespace: biological_process +def: "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732] +subset: goslim_pir +synonym: "clotting" EXACT [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0050818 +name: regulation of coagulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai] +synonym: "regulation of clotting" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050819 +name: negative regulation of coagulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai] +synonym: "anticoagulant activity" RELATED [] +synonym: "down regulation of coagulation" EXACT [] +synonym: "down-regulation of coagulation" EXACT [] +synonym: "downregulation of coagulation" EXACT [] +synonym: "inhibition of coagulation" NARROW [] +synonym: "negative regulation of clotting" EXACT [] +is_a: GO:0050818 ! regulation of coagulation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050820 +name: positive regulation of coagulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of coagulation." [GOC:ai] +synonym: "activation of coagulation" NARROW [] +synonym: "positive regulation of clotting" EXACT [] +synonym: "stimulation of coagulation" NARROW [] +synonym: "up regulation of coagulation" EXACT [] +synonym: "up-regulation of coagulation" EXACT [] +synonym: "upregulation of coagulation" EXACT [] +is_a: GO:0050818 ! regulation of coagulation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0050817 ! coagulation + +[Term] +id: GO:0050821 +name: protein stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] +subset: goslim_chembl +synonym: "lysosomal protein stabilization" NARROW [] +synonym: "positive regulation of protein stability" EXACT [] +synonym: "protein sequestering" RELATED [] +synonym: "protein stabilisation" EXACT [GOC:ah] +synonym: "protein stabilization activity" RELATED [] +is_a: GO:0031647 ! regulation of protein stability + +[Term] +id: GO:0050822 +name: peptide stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai] +synonym: "peptide stabilisation" EXACT [GOC:ah] +synonym: "peptide stabilization activity" RELATED [] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:0050823 +name: peptide antigen stabilization +namespace: biological_process +def: "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai] +synonym: "peptide antigen stabilization activity" RELATED [] +is_a: GO:0050822 ! peptide stabilization +relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen + +[Term] +id: GO:0050824 +name: obsolete water binding +namespace: molecular_function +def: "OBSOLETE. Binding to water (H2O)." [GOC:ai] +comment: This term was obsoleted because water binding is non-specific. +is_obsolete: true + +[Term] +id: GO:0050825 +name: ice binding +namespace: molecular_function +def: "Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators] +synonym: "antifreeze activity" RELATED [] +synonym: "ice crystal binding" EXACT [] +synonym: "ice nucleation activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050826 +name: response to freezing +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl] +synonym: "antifreeze activity" RELATED [] +synonym: "ice nucleation inhibitor activity" RELATED [] +is_a: GO:0009409 ! response to cold + +[Term] +id: GO:0050828 +name: regulation of liquid surface tension +namespace: biological_process +def: "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732] +synonym: "regulation of surface tension of a liquid" EXACT [] +synonym: "surfactant activity" RELATED [] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0050829 +name: defense response to Gram-negative bacterium +namespace: biological_process +def: "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to Gram-negative bacteria" EXACT [] +synonym: "defence response to Gram-negative bacterium" EXACT [] +synonym: "defense response to Gram-negative bacteria" EXACT [] +synonym: "Gram-negative antibacterial peptide activity" RELATED [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050830 +name: defense response to Gram-positive bacterium +namespace: biological_process +def: "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to Gram-positive bacteria" EXACT [] +synonym: "defence response to Gram-positive bacterium" EXACT [] +synonym: "defense response to Gram-positive bacteria" EXACT [] +synonym: "Gram-positive antibacterial peptide activity" RELATED [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050831 +name: male-specific defense response to bacterium +namespace: biological_process +def: "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai] +synonym: "male-specific antibacterial peptide activity" RELATED [] +synonym: "male-specific defence response to bacteria" EXACT [] +synonym: "male-specific defence response to bacterium" EXACT [] +synonym: "male-specific defense response to bacteria" EXACT [] +is_a: GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0050832 +name: defense response to fungus +namespace: biological_process +alt_id: GO:0009623 +alt_id: GO:0009817 +alt_id: GO:0042831 +def: "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai] +synonym: "defence response to fungi" EXACT [] +synonym: "defence response to fungus" EXACT [] +synonym: "defense response to fungi" EXACT [] +synonym: "defense response to fungus, incompatible interaction" NARROW [] +synonym: "resistance response to pathogenic fungi" NARROW [] +synonym: "resistance response to pathogenic fungus" NARROW [] +synonym: "response to parasitic fungi" NARROW [] +synonym: "response to parasitic fungus" NARROW [] +is_a: GO:0009620 ! response to fungus +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0050833 +name: pyruvate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other." [GOC:ai] +synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] +xref: Reactome:R-HSA-372342 "MPC1:MPC2 cotransports PYR, H+ from cytosol to mitochondrial matrix" +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0050834 +name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide +namespace: biological_process +def: "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] +xref: RESID:AA0355 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0050835 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356] +xref: RESID:AA0356 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster +is_a: GO:0050843 ! S-adenosylmethionine catabolic process + +[Term] +id: GO:0050836 +name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide +namespace: biological_process +def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357] +xref: RESID:AA0357 +is_a: GO:0018195 ! peptidyl-arginine modification +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster + +[Term] +id: GO:0050837 +name: peptide cross-linking via L-cysteinyl-L-selenocysteine +namespace: biological_process +def: "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358] +xref: RESID:AA0358 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0050838 +name: peptidyl-5-hydroxy-L-lysine trimethylation +namespace: biological_process +def: "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] +xref: RESID:AA0359 +is_a: GO:0018022 ! peptidyl-lysine methylation + +[Term] +id: GO:0050839 +name: cell adhesion molecule binding +namespace: molecular_function +def: "Binding to a cell adhesion molecule." [GOC:ai] +synonym: "adhesive extracellular matrix constituent" RELATED [] +synonym: "CAM binding" EXACT [] +synonym: "cell adhesion molecule activity" RELATED [] +synonym: "cell adhesion receptor activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0050840 +name: extracellular matrix binding +namespace: molecular_function +def: "Binding to a component of the extracellular matrix." [GOC:ai] +subset: goslim_chembl +subset: goslim_pir +synonym: "adhesive extracellular matrix constituent" RELATED [] +synonym: "extracellular matrix constituent binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050841 +name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine +namespace: biological_process +def: "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359] +synonym: "peptidyl trimethyl lysine hydroxylase activity" EXACT [] +synonym: "peptidyl-trimethyl-lysine hydroxylase activity" EXACT [] +xref: RESID:AA0359 +is_a: GO:0017185 ! peptidyl-lysine hydroxylation + +[Term] +id: GO:0050842 +name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide +namespace: biological_process +def: "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355] +xref: RESID:AA0355 +is_a: GO:0018198 ! peptidyl-cysteine modification +is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster + +[Term] +id: GO:0050843 +name: S-adenosylmethionine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] +synonym: "S-adenosyl methionine catabolic process" EXACT [] +synonym: "S-adenosyl methionine catabolism" EXACT [] +synonym: "S-adenosylmethionine breakdown" EXACT [] +synonym: "S-adenosylmethionine catabolism" EXACT [] +synonym: "S-adenosylmethionine degradation" EXACT [] +synonym: "SAM catabolic process" EXACT [] +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046500 ! S-adenosylmethionine metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0050844 +name: peptidyl-selenocysteine modification +namespace: biological_process +def: "The modification of peptidyl-selenocysteine." [GOC:ai] +is_a: GO:0018193 ! peptidyl-amino acid modification + +[Term] +id: GO:0050845 +name: teichuronic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] +synonym: "teichuronic acid anabolism" EXACT [] +synonym: "teichuronic acid biosynthesis" EXACT [] +synonym: "teichuronic acid formation" EXACT [] +synonym: "teichuronic acid synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process +is_a: GO:0050846 ! teichuronic acid metabolic process +relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0050846 +name: teichuronic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893] +synonym: "teichuronic acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process + +[Term] +id: GO:0050847 +name: progesterone receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870] +synonym: "progesterone receptor signalling pathway" EXACT [] +is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway + +[Term] +id: GO:0050848 +name: regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai] +synonym: "regulation of calcium-mediated signalling" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050849 +name: negative regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592] +synonym: "down regulation of calcium-mediated signaling" EXACT [] +synonym: "down-regulation of calcium-mediated signaling" EXACT [] +synonym: "downregulation of calcium-mediated signaling" EXACT [] +synonym: "inhibition of calcium-mediated signaling" NARROW [] +synonym: "negative regulation of calcium-mediated signalling" EXACT [] +is_a: GO:0050848 ! regulation of calcium-mediated signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050850 +name: positive regulation of calcium-mediated signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai] +synonym: "activation of calcium-mediated signaling" NARROW [] +synonym: "positive regulation of calcium-mediated signalling" EXACT [] +synonym: "stimulation of calcium-mediated signaling" NARROW [] +synonym: "up regulation of calcium-mediated signaling" EXACT [] +synonym: "up-regulation of calcium-mediated signaling" EXACT [] +synonym: "upregulation of calcium-mediated signaling" EXACT [] +is_a: GO:0050848 ! regulation of calcium-mediated signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0050851 +name: antigen receptor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add] +synonym: "antigen receptor-mediated signalling pathway" EXACT [] +is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway + +[Term] +id: GO:0050852 +name: T cell receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add] +synonym: "T lymphocyte receptor signaling pathway" EXACT [] +synonym: "T lymphocyte receptor signalling pathway" EXACT [] +synonym: "T-cell receptor signaling pathway" EXACT [] +synonym: "T-cell receptor signalling pathway" EXACT [] +synonym: "T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "TCR signaling pathway" EXACT [] +is_a: GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050853 +name: B cell receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add] +synonym: "B cell receptor signalling pathway" EXACT [] +synonym: "B lymphocyte receptor signaling pathway" EXACT [] +synonym: "B lymphocyte receptor signalling pathway" EXACT [] +synonym: "B-cell receptor signaling pathway" EXACT [] +synonym: "B-cell receptor signalling pathway" EXACT [] +synonym: "B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050854 +name: regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "regulation of antigen receptor mediated signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050855 +name: regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "regulation of B cell receptor signalling pathway" EXACT [] +synonym: "regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050856 +name: regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "regulation of T-cell receptor signalling pathway" EXACT [] +synonym: "regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "regulation of TCR signaling pathway" EXACT [] +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050857 +name: positive regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "activation of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "positive regulation of antigen receptor mediated signalling pathway" EXACT [] +synonym: "stimulation of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "up regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "up-regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "upregulation of antigen receptor-mediated signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050858 +name: negative regulation of antigen receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai] +synonym: "down regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "down-regulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "downregulation of antigen receptor-mediated signaling pathway" EXACT [] +synonym: "inhibition of antigen receptor-mediated signaling pathway" NARROW [] +synonym: "negative regulation of antigen receptor mediated signalling pathway" EXACT [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050854 ! regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050851 ! antigen receptor-mediated signaling pathway + +[Term] +id: GO:0050859 +name: negative regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "down regulation of B cell receptor signaling pathway" EXACT [] +synonym: "down-regulation of B cell receptor signaling pathway" EXACT [] +synonym: "downregulation of B cell receptor signaling pathway" EXACT [] +synonym: "inhibition of B cell receptor signaling pathway" NARROW [] +synonym: "negative regulation of B cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "negative regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of B-lymphocyte receptor signalling pathway" EXACT [] +is_a: GO:0050855 ! regulation of B cell receptor signaling pathway +is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050860 +name: negative regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "down regulation of T cell receptor signaling pathway" EXACT [] +synonym: "down-regulation of T cell receptor signaling pathway" EXACT [] +synonym: "downregulation of T cell receptor signaling pathway" EXACT [] +synonym: "inhibition of T cell receptor signaling pathway" NARROW [] +synonym: "negative regulation of T cell receptor signalling pathway" EXACT [] +synonym: "negative regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "negative regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "negative regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "negative regulation of TCR signaling pathway" EXACT [] +is_a: GO:0050856 ! regulation of T cell receptor signaling pathway +is_a: GO:0050858 ! negative regulation of antigen receptor-mediated signaling pathway +relationship: negatively_regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050861 +name: positive regulation of B cell receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai] +synonym: "activation of B cell receptor signaling pathway" NARROW [] +synonym: "positive regulation of B cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of B lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of B lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of B-cell receptor signaling pathway" EXACT [] +synonym: "positive regulation of B-cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of B-lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of B-lymphocyte receptor signalling pathway" EXACT [] +synonym: "stimulation of B cell receptor signaling pathway" NARROW [] +synonym: "up regulation of B cell receptor signaling pathway" EXACT [] +synonym: "up-regulation of B cell receptor signaling pathway" EXACT [] +synonym: "upregulation of B cell receptor signaling pathway" EXACT [] +is_a: GO:0050855 ! regulation of B cell receptor signaling pathway +is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050853 ! B cell receptor signaling pathway + +[Term] +id: GO:0050862 +name: positive regulation of T cell receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai] +synonym: "activation of T cell receptor signaling pathway" NARROW [] +synonym: "positive regulation of T cell receptor signalling pathway" EXACT [] +synonym: "positive regulation of T lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of T lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of T-cell receptor signaling pathway" EXACT [] +synonym: "positive regulation of T-lymphocyte receptor signaling pathway" EXACT [] +synonym: "positive regulation of T-lymphocyte receptor signalling pathway" EXACT [] +synonym: "positive regulation of TCR signaling pathway" EXACT [] +synonym: "stimulation of T cell receptor signaling pathway" NARROW [] +synonym: "up regulation of T cell receptor signaling pathway" EXACT [] +synonym: "up-regulation of T cell receptor signaling pathway" EXACT [] +synonym: "upregulation of T cell receptor signaling pathway" EXACT [] +is_a: GO:0050856 ! regulation of T cell receptor signaling pathway +is_a: GO:0050857 ! positive regulation of antigen receptor-mediated signaling pathway +relationship: positively_regulates GO:0050852 ! T cell receptor signaling pathway + +[Term] +id: GO:0050863 +name: regulation of T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "regulation of T lymphocyte activation" EXACT [] +synonym: "regulation of T-cell activation" EXACT [] +synonym: "regulation of T-lymphocyte activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050864 +name: regulation of B cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "regulation of B lymphocyte activation" EXACT [] +synonym: "regulation of B-cell activation" EXACT [] +synonym: "regulation of B-lymphocyte activation" EXACT [] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050865 +name: regulation of cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050866 +name: negative regulation of cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai] +synonym: "down regulation of cell activation" EXACT [] +synonym: "down-regulation of cell activation" EXACT [] +synonym: "downregulation of cell activation" EXACT [] +synonym: "inhibition of cell activation" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0050865 ! regulation of cell activation +relationship: negatively_regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050867 +name: positive regulation of cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activation." [GOC:ai] +synonym: "activation of cell activation" NARROW [] +synonym: "stimulation of cell activation" NARROW [] +synonym: "up regulation of cell activation" EXACT [] +synonym: "up-regulation of cell activation" EXACT [] +synonym: "upregulation of cell activation" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0050865 ! regulation of cell activation +relationship: positively_regulates GO:0001775 ! cell activation + +[Term] +id: GO:0050868 +name: negative regulation of T cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "down regulation of T cell activation" EXACT [] +synonym: "down-regulation of T cell activation" EXACT [] +synonym: "downregulation of T cell activation" EXACT [] +synonym: "inhibition of T cell activation" NARROW [] +synonym: "negative regulation of T lymphocyte activation" EXACT [] +synonym: "negative regulation of T-cell activation" EXACT [] +synonym: "negative regulation of T-lymphocyte activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion +relationship: negatively_regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050869 +name: negative regulation of B cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "down regulation of B cell activation" EXACT [] +synonym: "down-regulation of B cell activation" EXACT [] +synonym: "downregulation of B cell activation" EXACT [] +synonym: "inhibition of B cell activation" NARROW [] +synonym: "negative regulation of B lymphocyte activation" EXACT [] +synonym: "negative regulation of B-cell activation" EXACT [] +synonym: "negative regulation of B-lymphocyte activation" EXACT [] +is_a: GO:0050864 ! regulation of B cell activation +is_a: GO:0051250 ! negative regulation of lymphocyte activation +relationship: negatively_regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050870 +name: positive regulation of T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai] +synonym: "activation of T cell activation" NARROW [] +synonym: "positive regulation of T lymphocyte activation" EXACT [] +synonym: "positive regulation of T-cell activation" EXACT [] +synonym: "positive regulation of T-lymphocyte activation" EXACT [] +synonym: "stimulation of T cell activation" NARROW [] +synonym: "up regulation of T cell activation" EXACT [] +synonym: "up-regulation of T cell activation" EXACT [] +synonym: "upregulation of T cell activation" EXACT [] +is_a: GO:0050863 ! regulation of T cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion +relationship: positively_regulates GO:0042110 ! T cell activation + +[Term] +id: GO:0050871 +name: positive regulation of B cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai] +synonym: "activation of B cell activation" NARROW [] +synonym: "positive regulation of B lymphocyte activation" EXACT [] +synonym: "positive regulation of B-cell activation" EXACT [] +synonym: "positive regulation of B-lymphocyte activation" EXACT [] +synonym: "stimulation of B cell activation" NARROW [] +synonym: "up regulation of B cell activation" EXACT [] +synonym: "up-regulation of B cell activation" EXACT [] +synonym: "upregulation of B cell activation" EXACT [] +is_a: GO:0050864 ! regulation of B cell activation +is_a: GO:0051251 ! positive regulation of lymphocyte activation +relationship: positively_regulates GO:0042113 ! B cell activation + +[Term] +id: GO:0050872 +name: white fat cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945] +synonym: "white adipocyte cell differentiation" EXACT [] +synonym: "white adipocyte differentiation" EXACT [] +is_a: GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0050873 +name: brown fat cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810] +synonym: "brown adipocyte cell differentiation" EXACT [] +synonym: "brown adipocyte differentiation" EXACT [] +is_a: GO:0045444 ! fat cell differentiation + +[Term] +id: GO:0050877 +name: nervous system process +namespace: biological_process +def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_pir +synonym: "neurological system process" EXACT [] +synonym: "neurophysiological process" EXACT [] +synonym: "pan-neural process" RELATED [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0050878 +name: regulation of body fluid levels +namespace: biological_process +def: "Any process that modulates the levels of body fluids." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_pir +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0050879 +name: multicellular organismal movement +namespace: biological_process +def: "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb] +subset: goslim_pir +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0050881 +name: musculoskeletal movement +namespace: biological_process +def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph] +is_a: GO:0050879 ! multicellular organismal movement +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0050882 +name: voluntary musculoskeletal movement +namespace: biological_process +def: "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph] +is_a: GO:0050881 ! musculoskeletal movement + +[Term] +id: GO:0050883 +name: musculoskeletal movement, spinal reflex action +namespace: biological_process +def: "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph] +is_a: GO:0050881 ! musculoskeletal movement +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0050884 +name: neuromuscular process controlling posture +namespace: biological_process +def: "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb] +synonym: "regulation of posture" EXACT [] +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0050885 +name: neuromuscular process controlling balance +namespace: biological_process +def: "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph] +synonym: "regulation of balance" RELATED [] +is_a: GO:0050905 ! neuromuscular process + +[Term] +id: GO:0050886 +name: endocrine process +namespace: biological_process +def: "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544] +subset: goslim_generic +subset: goslim_pir +synonym: "endocrine physiological process" EXACT [] +synonym: "endocrine physiology" EXACT [] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0050887 +name: determination of sensory modality +namespace: biological_process +def: "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050888 +name: determination of stimulus location +namespace: biological_process +def: "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050889 +name: determination of stimulus intensity +namespace: biological_process +def: "The determination of the perceived strength of a sensory stimulus." [ISBN:0721619908] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050890 +name: cognition +namespace: biological_process +def: "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [ISBN:0721619908] +subset: goslim_drosophila +xref: Wikipedia:Cognition +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0050891 +name: multicellular organismal water homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb] +synonym: "body fluid osmoregulation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0030104 ! water homeostasis +is_a: GO:0048871 ! multicellular organismal homeostasis +is_a: GO:0050878 ! regulation of body fluid levels + +[Term] +id: GO:0050892 +name: intestinal absorption +namespace: biological_process +def: "Any process in which nutrients are taken up from the contents of the intestine." [GOC:ai, GOC:dph] +is_a: GO:0006810 ! transport +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0050893 +name: sensory processing +namespace: biological_process +def: "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544] +is_a: GO:0050890 ! cognition +relationship: part_of GO:0007600 ! sensory perception + +[Term] +id: GO:0050894 +name: determination of affect +namespace: biological_process +def: "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544] +is_a: GO:0050893 ! sensory processing + +[Term] +id: GO:0050896 +name: response to stimulus +namespace: biological_process +alt_id: GO:0051869 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_agr +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +synonym: "physiological response to stimulus" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0050897 +name: cobalt ion binding +namespace: molecular_function +def: "Binding to a cobalt ion (Co)." [GOC:ai] +synonym: "Co ion binding" EXACT [] +synonym: "cobalt binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0050898 +name: nitrile metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [PMID:18987211] +synonym: "nitrile metabolism" EXACT [] +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0050899 +name: nitrile catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544] +synonym: "nitrile breakdown" EXACT [] +synonym: "nitrile catabolism" EXACT [] +synonym: "nitrile degradation" EXACT [] +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0050898 ! nitrile metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0050900 +name: leukocyte migration +namespace: biological_process +def: "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "immune cell migration" EXACT [] +synonym: "immune cell trafficking" EXACT [] +synonym: "leucocyte migration" EXACT [] +synonym: "leucocyte trafficking" EXACT [] +synonym: "leukocyte trafficking" EXACT [] +is_a: GO:0002376 ! immune system process +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0050901 +name: leukocyte tethering or rolling +namespace: biological_process +def: "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)." [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation] +is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050902 +name: leukocyte adhesive activation +namespace: biological_process +def: "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +synonym: "leukocyte adhesive triggering" EXACT [] +is_a: GO:0045321 ! leukocyte activation +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050903 +name: leukocyte activation-dependent arrest +namespace: biological_process +def: "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050904 +name: diapedesis +namespace: biological_process +def: "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] +comment: Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. +is_a: GO:0050900 ! leukocyte migration +relationship: part_of GO:0045123 ! cellular extravasation + +[Term] +id: GO:0050905 +name: neuromuscular process +namespace: biological_process +def: "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai] +synonym: "neuromotor process" EXACT [] +synonym: "neuromuscular physiological process" EXACT [] +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0050906 +name: detection of stimulus involved in sensory perception +namespace: biological_process +def: "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph] +synonym: "sensory detection of stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of stimulus" EXACT [] +synonym: "sensory perception, stimulus detection" EXACT [] +synonym: "sensory transduction" EXACT [] +xref: Wikipedia:Transduction_(physiology) +is_a: GO:0051606 ! detection of stimulus +relationship: part_of GO:0007600 ! sensory perception + +[Term] +id: GO:0050907 +name: detection of chemical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] +synonym: "sensory detection of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of chemical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory transduction of chemical stimulus during sensory perception" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0050908 +name: detection of light stimulus involved in visual perception +namespace: biological_process +def: "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +synonym: "sensory detection of light during visual perception" EXACT [] +synonym: "sensory detection of light stimulus during visual perception" EXACT [] +synonym: "sensory transduction of light during visual perception" EXACT [] +synonym: "sensory transduction of light stimulus during visual perception" EXACT [] +synonym: "visual perception, detection of light stimulus" EXACT [] +synonym: "visual perception, sensory transduction during perception of light" EXACT [] +synonym: "visual perception, sensory transduction of light stimulus" EXACT [] +is_a: GO:0009584 ! detection of visible light +is_a: GO:0050962 ! detection of light stimulus involved in sensory perception +relationship: part_of GO:0007601 ! visual perception + +[Term] +id: GO:0050909 +name: sensory perception of taste +namespace: biological_process +def: "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai] +synonym: "gustation" EXACT [] +synonym: "sense of taste" EXACT [] +synonym: "taste" EXACT [] +synonym: "taste perception" EXACT [] +xref: Wikipedia:Taste +is_a: GO:0007606 ! sensory perception of chemical stimulus + +[Term] +id: GO:0050910 +name: detection of mechanical stimulus involved in sensory perception of sound +namespace: biological_process +alt_id: GO:0009592 +alt_id: GO:0055128 +def: "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai] +synonym: "detection of sound" EXACT [] +synonym: "hearing, sensory transduction of sound" EXACT [] +synonym: "perception of sound, detection of mechanical stimulus" EXACT [] +synonym: "perception of sound, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of sound, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of sound" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of sound" EXACT [] +synonym: "sensory transduction of sound" EXACT [] +is_a: GO:0050877 ! nervous system process +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0007605 ! sensory perception of sound + +[Term] +id: GO:0050911 +name: detection of chemical stimulus involved in sensory perception of smell +namespace: biological_process +def: "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai] +synonym: "perception of smell, detection of chemical stimulus" EXACT [] +synonym: "perception of smell, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of smell, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of smell" EXACT [] +synonym: "sensory detection of scent" EXACT [] +synonym: "sensory detection of smell" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of smell" EXACT [] +synonym: "sensory transduction of scent" EXACT [] +synonym: "sensory transduction of smell" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0007608 ! sensory perception of smell + +[Term] +id: GO:0050912 +name: detection of chemical stimulus involved in sensory perception of taste +namespace: biological_process +def: "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai] +synonym: "perception of taste, detection of chemical stimulus" EXACT [] +synonym: "perception of taste, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of taste, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of taste" EXACT [] +synonym: "sensory detection of taste" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of taste" EXACT [] +synonym: "sensory transduction of taste" EXACT [] +synonym: "taste perception" BROAD [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050913 +name: sensory perception of bitter taste +namespace: biological_process +def: "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "bitter taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050914 +name: sensory perception of salty taste +namespace: biological_process +def: "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "salty taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050915 +name: sensory perception of sour taste +namespace: biological_process +def: "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "sour taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050916 +name: sensory perception of sweet taste +namespace: biological_process +def: "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "sweet taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050917 +name: sensory perception of umami taste +namespace: biological_process +def: "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai] +synonym: "umami taste perception" EXACT [] +is_a: GO:0050909 ! sensory perception of taste + +[Term] +id: GO:0050918 +name: positive chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] +synonym: "chemoattraction" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0050919 +name: negative chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete] +synonym: "chemoaversion" EXACT [] +synonym: "chemorepulsion" EXACT [] +is_a: GO:0006935 ! chemotaxis + +[Term] +id: GO:0050920 +name: regulation of chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0040012 ! regulation of locomotion +relationship: regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050921 +name: positive regulation of chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +synonym: "activation of chemotaxis" NARROW [] +synonym: "stimulation of chemotaxis" NARROW [] +synonym: "up regulation of chemotaxis" EXACT [] +synonym: "up-regulation of chemotaxis" EXACT [] +synonym: "upregulation of chemotaxis" EXACT [] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0050920 ! regulation of chemotaxis +relationship: positively_regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050922 +name: negative regulation of chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai] +synonym: "down regulation of chemotaxis" EXACT [] +synonym: "down-regulation of chemotaxis" EXACT [] +synonym: "downregulation of chemotaxis" EXACT [] +synonym: "inhibition of chemotaxis" NARROW [] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0050920 ! regulation of chemotaxis +relationship: negatively_regulates GO:0006935 ! chemotaxis + +[Term] +id: GO:0050923 +name: regulation of negative chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050924 +name: positive regulation of negative chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "activation of negative chemotaxis" NARROW [] +synonym: "stimulation of negative chemotaxis" NARROW [] +synonym: "up regulation of negative chemotaxis" EXACT [] +synonym: "up-regulation of negative chemotaxis" EXACT [] +synonym: "upregulation of negative chemotaxis" EXACT [] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:0050923 ! regulation of negative chemotaxis +relationship: positively_regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050925 +name: negative regulation of negative chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "down regulation of negative chemotaxis" EXACT [] +synonym: "down-regulation of negative chemotaxis" EXACT [] +synonym: "downregulation of negative chemotaxis" EXACT [] +synonym: "inhibition of negative chemotaxis" NARROW [] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0050923 ! regulation of negative chemotaxis +relationship: negatively_regulates GO:0050919 ! negative chemotaxis + +[Term] +id: GO:0050926 +name: regulation of positive chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050927 +name: positive regulation of positive chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "activation of positive chemotaxis" NARROW [] +synonym: "stimulation of positive chemotaxis" NARROW [] +synonym: "up regulation of positive chemotaxis" EXACT [] +synonym: "up-regulation of positive chemotaxis" EXACT [] +synonym: "upregulation of positive chemotaxis" EXACT [] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:0050926 ! regulation of positive chemotaxis +relationship: positively_regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050928 +name: negative regulation of positive chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +synonym: "down regulation of positive chemotaxis" EXACT [] +synonym: "down-regulation of positive chemotaxis" EXACT [] +synonym: "downregulation of positive chemotaxis" EXACT [] +synonym: "inhibition of positive chemotaxis" NARROW [] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0050926 ! regulation of positive chemotaxis +relationship: negatively_regulates GO:0050918 ! positive chemotaxis + +[Term] +id: GO:0050929 +name: induction of negative chemotaxis +namespace: biological_process +def: "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050924 ! positive regulation of negative chemotaxis + +[Term] +id: GO:0050930 +name: induction of positive chemotaxis +namespace: biological_process +def: "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai] +is_a: GO:0050927 ! positive regulation of positive chemotaxis + +[Term] +id: GO:0050931 +name: pigment cell differentiation +namespace: biological_process +alt_id: GO:0043357 +alt_id: GO:0043358 +def: "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh] +comment: Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. +synonym: "chromatophore differentiation" EXACT [] +synonym: "pigmented cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0048066 ! developmental pigmentation + +[Term] +id: GO:0050932 +name: regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050933 +name: early stripe melanocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836] +synonym: "early stripe melanocyte cell differentiation" EXACT [] +synonym: "early stripe melanophore differentiation" EXACT [] +is_a: GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0050934 +name: late stripe melanocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836] +synonym: "late stripe melanocyte cell differentiation" EXACT [] +synonym: "late stripe melanophore differentiation" EXACT [] +is_a: GO:0030318 ! melanocyte differentiation + +[Term] +id: GO:0050935 +name: iridophore differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836] +synonym: "iridophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050936 +name: xanthophore differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "xanthophore cell differentiation" EXACT [] +is_a: GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050937 +name: regulation of iridophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iridophore differentiation." [GOC:ai] +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050938 +name: regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050939 +name: regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "regulation of early stripe melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +relationship: regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050940 +name: regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "regulation of late stripe melanophore differentiation" EXACT [] +is_a: GO:0045634 ! regulation of melanocyte differentiation +relationship: regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050941 +name: negative regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai] +synonym: "down regulation of pigment cell differentiation" EXACT [] +synonym: "down-regulation of pigment cell differentiation" EXACT [] +synonym: "downregulation of pigment cell differentiation" EXACT [] +synonym: "inhibition of pigment cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0048086 ! negative regulation of developmental pigmentation +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050942 +name: positive regulation of pigment cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai] +synonym: "activation of pigment cell differentiation" NARROW [] +synonym: "stimulation of pigment cell differentiation" NARROW [] +synonym: "up regulation of pigment cell differentiation" EXACT [] +synonym: "up-regulation of pigment cell differentiation" EXACT [] +synonym: "upregulation of pigment cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0048087 ! positive regulation of developmental pigmentation +is_a: GO:0050932 ! regulation of pigment cell differentiation +relationship: positively_regulates GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0050943 +name: negative regulation of iridophore differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai] +synonym: "down regulation of iridophore differentiation" EXACT [] +synonym: "down-regulation of iridophore differentiation" EXACT [] +synonym: "downregulation of iridophore differentiation" EXACT [] +synonym: "inhibition of iridophore differentiation" NARROW [] +is_a: GO:0050937 ! regulation of iridophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050944 +name: negative regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "down regulation of xanthophore differentiation" EXACT [] +synonym: "down-regulation of xanthophore differentiation" EXACT [] +synonym: "downregulation of xanthophore differentiation" EXACT [] +synonym: "inhibition of xanthophore differentiation" NARROW [] +is_a: GO:0050938 ! regulation of xanthophore differentiation +is_a: GO:0050941 ! negative regulation of pigment cell differentiation +relationship: negatively_regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050945 +name: positive regulation of iridophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai] +synonym: "activation of iridophore differentiation" NARROW [] +synonym: "stimulation of iridophore differentiation" NARROW [] +synonym: "up regulation of iridophore differentiation" EXACT [] +synonym: "up-regulation of iridophore differentiation" EXACT [] +synonym: "upregulation of iridophore differentiation" EXACT [] +is_a: GO:0050937 ! regulation of iridophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0050935 ! iridophore differentiation + +[Term] +id: GO:0050946 +name: positive regulation of xanthophore differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai] +comment: Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. +synonym: "activation of xanthophore differentiation" NARROW [] +synonym: "stimulation of xanthophore differentiation" NARROW [] +synonym: "up regulation of xanthophore differentiation" EXACT [] +synonym: "up-regulation of xanthophore differentiation" EXACT [] +synonym: "upregulation of xanthophore differentiation" EXACT [] +is_a: GO:0050938 ! regulation of xanthophore differentiation +is_a: GO:0050942 ! positive regulation of pigment cell differentiation +relationship: positively_regulates GO:0050936 ! xanthophore differentiation + +[Term] +id: GO:0050947 +name: negative regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "down regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "down-regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "downregulation of early stripe melanocyte differentiation" EXACT [] +synonym: "inhibition of early stripe melanocyte differentiation" NARROW [] +synonym: "negative regulation of early stripe melanophore differentiation" EXACT [] +is_a: GO:0045635 ! negative regulation of melanocyte differentiation +is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation +relationship: negatively_regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050948 +name: positive regulation of early stripe melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai] +synonym: "activation of early stripe melanocyte differentiation" NARROW [] +synonym: "positive regulation of early stripe melanophore differentiation" EXACT [] +synonym: "stimulation of early stripe melanocyte differentiation" NARROW [] +synonym: "up regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "up-regulation of early stripe melanocyte differentiation" EXACT [] +synonym: "upregulation of early stripe melanocyte differentiation" EXACT [] +is_a: GO:0045636 ! positive regulation of melanocyte differentiation +is_a: GO:0050939 ! regulation of early stripe melanocyte differentiation +relationship: positively_regulates GO:0050933 ! early stripe melanocyte differentiation + +[Term] +id: GO:0050949 +name: negative regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "down regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "down-regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "downregulation of late stripe melanocyte differentiation" EXACT [] +synonym: "inhibition of late stripe melanocyte differentiation" NARROW [] +synonym: "negative regulation of late stripe melanophore differentiation" EXACT [] +is_a: GO:0045635 ! negative regulation of melanocyte differentiation +is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation +relationship: negatively_regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050950 +name: positive regulation of late stripe melanocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai] +synonym: "activation of late stripe melanocyte differentiation" NARROW [] +synonym: "positive regulation of late stripe melanophore differentiation" EXACT [] +synonym: "stimulation of late stripe melanocyte differentiation" NARROW [] +synonym: "up regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "up-regulation of late stripe melanocyte differentiation" EXACT [] +synonym: "upregulation of late stripe melanocyte differentiation" EXACT [] +is_a: GO:0045636 ! positive regulation of melanocyte differentiation +is_a: GO:0050940 ! regulation of late stripe melanocyte differentiation +relationship: positively_regulates GO:0050934 ! late stripe melanocyte differentiation + +[Term] +id: GO:0050951 +name: sensory perception of temperature stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "sensory perception of thermal stimulus" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050952 +name: sensory perception of electrical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050953 +name: sensory perception of light stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050954 +name: sensory perception of mechanical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] +synonym: "chemi-mechanical coupling" RELATED [] +synonym: "mechanosensory perception" EXACT [] +synonym: "perception of mechanical stimulus" EXACT [] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050955 +name: thermoception +namespace: biological_process +def: "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception] +synonym: "thermoreception" EXACT [] +xref: Wikipedia:Thermoception +is_a: GO:0050951 ! sensory perception of temperature stimulus + +[Term] +id: GO:0050956 +name: electroception +namespace: biological_process +def: "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception] +synonym: "electroception sense" EXACT [] +synonym: "electroceptive sense" EXACT [] +xref: Wikipedia:Electroreception +is_a: GO:0050952 ! sensory perception of electrical stimulus + +[Term] +id: GO:0050957 +name: equilibrioception +namespace: biological_process +def: "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com] +synonym: "sensory perception of orientation with respect to gravity" EXACT [] +xref: Wikipedia:Equilibrioception +is_a: GO:0007600 ! sensory perception +relationship: part_of GO:0050885 ! neuromuscular process controlling balance + +[Term] +id: GO:0050958 +name: magnetoreception +namespace: biological_process +def: "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] +synonym: "magnetoception" EXACT [] +synonym: "sensory perception of magnetic field" EXACT [] +xref: Wikipedia:Magnetoception +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0050959 +name: echolocation +namespace: biological_process +def: "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [PMID:16005275, Wikipedia:Animal_echolocation] +synonym: "biological sonar" EXACT [https://en.wikipedia.org/wiki/Animal_echolocation] +synonym: "perception of environment using reflected sound waves" EXACT [] +xref: Wikipedia:Echolocation +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0050960 +name: detection of temperature stimulus involved in thermoception +namespace: biological_process +def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos] +synonym: "sensory detection of temperature stimulus during thermoception" EXACT [] +synonym: "sensory detection of thermal stimulus during thermoception" EXACT [] +synonym: "sensory transduction of temperature stimulus during thermoception" EXACT [] +synonym: "sensory transduction of thermal stimulus during thermoception" EXACT [] +synonym: "thermoception, sensory detection of temperature stimulus" EXACT [] +synonym: "thermoception, sensory detection of thermal stimulus" EXACT [] +synonym: "thermoception, sensory transduction of temperature stimulus" EXACT [] +synonym: "thermoception, sensory transduction of thermal stimulus" EXACT [] +is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception +relationship: part_of GO:0050955 ! thermoception + +[Term] +id: GO:0050961 +name: detection of temperature stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] +synonym: "sensory detection of heat stimulus during sensory perception" NARROW [] +synonym: "sensory detection of temperature stimulus" EXACT [] +synonym: "sensory detection of temperature stimulus during sensory perception" EXACT [] +synonym: "sensory detection of thermal stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of heat stimulus" NARROW [] +synonym: "sensory perception, sensory detection of temperature stimulus" EXACT [] +synonym: "sensory perception, sensory detection of thermal stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of heat stimulus" NARROW [] +synonym: "sensory perception, sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of thermal stimulus" EXACT [] +synonym: "sensory transduction of heat stimulus during sensory perception" NARROW [] +synonym: "sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory transduction of temperature stimulus during sensory perception" EXACT [] +synonym: "sensory transduction of thermal stimulus during sensory perception" EXACT [] +is_a: GO:0016048 ! detection of temperature stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0050951 ! sensory perception of temperature stimulus + +[Term] +id: GO:0050962 +name: detection of light stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos] +synonym: "sensory detection of light stimulus" EXACT [] +synonym: "sensory detection of light stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of light stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of light stimulus" EXACT [] +synonym: "sensory transduction of light stimulus" EXACT [] +synonym: "sensory transduction of light stimulus during sensory perception" EXACT [] +is_a: GO:0009583 ! detection of light stimulus +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0050953 ! sensory perception of light stimulus + +[Term] +id: GO:0050963 +name: detection of electrical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] +synonym: "sensory detection of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of electrical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory transduction of electrical stimulus during sensory perception" EXACT [] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +is_a: GO:0050981 ! detection of electrical stimulus +relationship: part_of GO:0050952 ! sensory perception of electrical stimulus + +[Term] +id: GO:0050964 +name: detection of electrical stimulus involved in electroception +namespace: biological_process +def: "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +synonym: "detection of electrical stimulus during electroreception" RELATED [GOC:dph, GOC:tb] +synonym: "electroception, detection of electrical stimulus" EXACT [] +synonym: "electroception, sensory detection of electrical stimulus" EXACT [] +synonym: "electroception, sensory transduction" EXACT [] +synonym: "electroception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during electroception" RELATED [] +synonym: "sensory transduction of electrical stimulus during electroception" RELATED [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +relationship: part_of GO:0050956 ! electroception + +[Term] +id: GO:0050965 +name: detection of temperature stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +synonym: "perception of pain, detection of temperature stimulus" EXACT [] +synonym: "perception of pain, sensory detection of temperature stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of temperature stimulus" EXACT [] +synonym: "sensory detection of temperature stimulus during perception of pain" EXACT [] +synonym: "sensory detection of thermal stimulus during sensory perception of pain" EXACT [] +synonym: "sensory perception of pain, sensory detection of thermal stimulus" EXACT [] +synonym: "sensory perception of pain, sensory transduction of thermal stimulus" EXACT [] +synonym: "sensory transduction of temperature stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of thermal stimulus during sensory perception of pain" EXACT [] +synonym: "thermal nociception" RELATED [GOC:pr] +is_a: GO:0050961 ! detection of temperature stimulus involved in sensory perception +is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain + +[Term] +id: GO:0050966 +name: detection of mechanical stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +synonym: "mechanical nociception" RELATED [GOC:pr] +synonym: "perception of pain, detection of mechanical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of pain" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain + +[Term] +id: GO:0050967 +name: detection of electrical stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] +synonym: "detection of electrical stimulus during sensory perception of pain" RELATED [GOC:dph, GOC:tb] +synonym: "perception of pain, detection of electrical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of electrical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during perception of pain" RELATED [] +synonym: "sensory transduction of electrical stimulus during perception of pain" RELATED [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain + +[Term] +id: GO:0050968 +name: detection of chemical stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai] +synonym: "chemical nociception" RELATED [GOC:pr] +synonym: "perception of pain, detection of chemical stimulus" EXACT [] +synonym: "perception of pain, sensory detection of chemical stimulus" EXACT [] +synonym: "perception of pain, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during perception of pain" EXACT [] +synonym: "sensory transduction of chemical stimulus during perception of pain" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +is_a: GO:0062149 ! detection of stimulus involved in sensory perception of pain + +[Term] +id: GO:0050969 +name: detection of chemical stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai, GOC:dos] +synonym: "magnetoception, sensory transduction of chemical stimulus" EXACT [] +synonym: "magnetoreception, detection of chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of chemical stimulus" EXACT [] +synonym: "sensory detection of chemical stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of chemical stimulus during magnetoreception" EXACT [] +is_a: GO:0050907 ! detection of chemical stimulus involved in sensory perception +relationship: part_of GO:0050977 ! magnetoreception by sensory perception of chemical stimulus + +[Term] +id: GO:0050970 +name: detection of electrical stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception] +synonym: "detection of electrical stimulus during magnetoreception" RELATED [GOC:dph, GOC:tb] +synonym: "magnetoception, sensory transduction of electrical stimulus" EXACT [] +synonym: "magnetoreception, detection of electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of electrical stimulus" EXACT [] +synonym: "sensory detection of electrical stimulus during magnetoreception" RELATED [] +synonym: "sensory transduction of electrical stimulus during magnetoreception" RELATED [] +is_a: GO:0050963 ! detection of electrical stimulus involved in sensory perception +relationship: part_of GO:0050978 ! magnetoreception by sensory perception of electrical stimulus + +[Term] +id: GO:0050971 +name: detection of mechanical stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai, GOC:dos] +synonym: "magnetoception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "magnetoreception, detection of mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of mechanical stimulus during magnetoreception" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050979 ! magnetoreception by sensory perception of mechanical stimulus + +[Term] +id: GO:0050972 +name: detection of mechanical stimulus involved in echolocation +namespace: biological_process +def: "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai, GOC:dos] +synonym: "echolocation, detection of mechanical stimulus" EXACT [] +synonym: "echolocation, sensory detection of mechanical stimulus" EXACT [] +synonym: "echolocation, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during echolocation" EXACT [] +synonym: "sensory transduction of mechanical stimulus during echolocation" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050959 ! echolocation + +[Term] +id: GO:0050973 +name: detection of mechanical stimulus involved in equilibrioception +namespace: biological_process +def: "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos] +synonym: "equilibrioception, detection of mechanical stimulus" EXACT [] +synonym: "equilibrioception, sensory detection of mechanical stimulus" EXACT [] +synonym: "equilibrioception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during equilibrioception" EXACT [] +synonym: "sensory transduction of mechanical stimulus during equilibrioception" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0050974 +name: detection of mechanical stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos] +synonym: "sensory detection of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during sensory perception" EXACT [] +synonym: "sensory perception, sensory detection of mechanical stimulus" EXACT [] +synonym: "sensory perception, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory transduction of mechanical stimulus during sensory perception" EXACT [] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +is_a: GO:0050982 ! detection of mechanical stimulus +relationship: part_of GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0050975 +name: sensory perception of touch +namespace: biological_process +def: "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai] +synonym: "perception of touch" EXACT [] +synonym: "tactile sense" EXACT [] +synonym: "taction" EXACT [] +synonym: "tactition" EXACT [] +xref: Wikipedia:Touch +is_a: GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0050976 +name: detection of mechanical stimulus involved in sensory perception of touch +namespace: biological_process +def: "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +synonym: "perception of touch, detection of mechanical stimulus" EXACT [] +synonym: "perception of touch, sensory detection of mechanical stimulus" EXACT [] +synonym: "perception of touch, sensory transduction of mechanical stimulus" EXACT [] +synonym: "sensory detection of mechanical stimulus during perception of touch" EXACT [] +synonym: "sensory transduction of mechanical stimulus during perception of touch" EXACT [] +synonym: "tactition, sensory detection of mechanical stimulus" EXACT [] +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0050975 ! sensory perception of touch + +[Term] +id: GO:0050977 +name: magnetoreception by sensory perception of chemical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] +synonym: "magnetoreception by chemical stimulus" EXACT [] +synonym: "magnetoreception through chemical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of chemical stimulus" EXACT [] +synonym: "magnetoreception, using chemical stimulus" EXACT [GOC:dph, GOC:tb] +is_a: GO:0007606 ! sensory perception of chemical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050978 +name: magnetoreception by sensory perception of electrical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] +synonym: "magnetoreception by electrical stimulus" EXACT [] +synonym: "magnetoreception through electrical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of electrical stimulus" EXACT [] +synonym: "magnetoreception, using electrical stimulus" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050952 ! sensory perception of electrical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050979 +name: magnetoreception by sensory perception of mechanical stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception] +synonym: "magnetoreception through mechanical stimulus" EXACT [] +synonym: "magnetoreception, sensory perception of mechanical stimulus" EXACT [] +synonym: "magnetoreception, using mechanical stimulus" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050954 ! sensory perception of mechanical stimulus +is_a: GO:0050958 ! magnetoreception + +[Term] +id: GO:0050980 +name: detection of light stimulus involved in magnetoreception +namespace: biological_process +def: "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception] +synonym: "magnetoreception, detection of light stimulus" EXACT [] +synonym: "magnetoreception, sensory detection of light stimulus" EXACT [] +synonym: "magnetoreception, sensory transduction of light stimulus" EXACT [] +synonym: "sensory detection of light stimulus during magnetoreception" EXACT [] +synonym: "sensory transduction of light stimulus during magnetoreception" EXACT [] +is_a: GO:0050962 ! detection of light stimulus involved in sensory perception +relationship: part_of GO:0050958 ! magnetoreception + +[Term] +id: GO:0050981 +name: detection of electrical stimulus +namespace: biological_process +def: "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0051602 ! response to electrical stimulus + +[Term] +id: GO:0050982 +name: detection of mechanical stimulus +namespace: biological_process +def: "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:0050983 +name: obsolete deoxyhypusine biosynthetic process from spermidine +namespace: biological_process +def: "OBSOLETE. The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN] +comment: The reason for obsoletion is that although GO:0050983 is described as a multistep process, the entire reaction is carried out by a single enzyme, therefore was replacey by the molecular function GO:0034038 deoxyhypusine synthase activity. +synonym: "deoxyhypusine anabolism from spermidine, using deoxyhypusine synthase" EXACT [] +synonym: "deoxyhypusine biosynthesis from spermidine, using deoxyhypusine synthase" EXACT [] +synonym: "deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase" EXACT [] +synonym: "deoxyhypusine formation from spermidine, using deoxyhypusine synthase" EXACT [] +synonym: "spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase" EXACT [] +synonym: "spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase" EXACT [] +synonym: "spermidine degradation to deoxyhypusine, using deoxyhypusine synthase" EXACT [] +is_obsolete: true +consider: GO:0034038 + +[Term] +id: GO:0050984 +name: peptidyl-serine sulfation +namespace: biological_process +def: "The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine." [RESID:AA0361] +xref: RESID:AA0361 +is_a: GO:0006477 ! protein sulfation +is_a: GO:0018209 ! peptidyl-serine modification + +[Term] +id: GO:0050985 +name: peptidyl-threonine sulfation +namespace: biological_process +def: "The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine." [RESID:AA0362] +xref: RESID:AA0362 +is_a: GO:0006477 ! protein sulfation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0050986 +name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine +namespace: biological_process +def: "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360] +xref: RESID:AA0360 +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018262 ! isopeptide cross-linking + +[Term] +id: GO:0050987 +name: obsolete enzyme active site formation via O-sulfo-L-serine +namespace: biological_process +def: "OBSOLETE. The transient sulfation of peptidyl-serine to form O-sulfo-L-serine." [RESID:AA0361] +comment: This term was obsoleted because it was created by error: O-sulfo-L-serine is a post-translational modification, see PMID:14752058. +xref: RESID:AA0361 +is_obsolete: true + +[Term] +id: GO:0050988 +name: N-terminal peptidyl-methionine carboxylation +namespace: biological_process +def: "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363] +xref: RESID:AA0363 +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0050989 ! N-terminal protein amino acid carboxylation + +[Term] +id: GO:0050989 +name: N-terminal protein amino acid carboxylation +namespace: biological_process +def: "The carboxylation of the N-terminal amino acid of proteins." [GOC:ai] +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0050990 +name: N-terminal protein amino acid carbamoylation +namespace: biological_process +def: "The carbamoylation of the N-terminal amino acid of proteins." [GOC:ai] +synonym: "N-terminal protein amino acid carbamylation" EXACT [] +is_a: GO:0031365 ! N-terminal protein amino acid modification + +[Term] +id: GO:0050991 +name: obsolete enzyme active site formation via O-sulfo-L-threonine +namespace: biological_process +def: "OBSOLETE. The transient sulfation of peptidyl-threonine to form O-sulfo-L-threonine." [RESID:AA0362] +comment: This term was obsoleted because it was created by error: O-sulfo-L-threonine is a post-translational modification, see PMID:14752058. +xref: RESID:AA0362 +is_obsolete: true + +[Term] +id: GO:0050992 +name: dimethylallyl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai] +synonym: "dimethylallyl diphosphate anabolism" EXACT [] +synonym: "dimethylallyl diphosphate biosynthesis" EXACT [] +synonym: "dimethylallyl diphosphate formation" EXACT [] +synonym: "dimethylallyl diphosphate synthesis" EXACT [] +synonym: "dimethylallyl pyrophosphate biosynthesis" EXACT [] +synonym: "dimethylallyl pyrophosphate biosynthetic process" EXACT [] +synonym: "DPP biosynthesis" EXACT [] +synonym: "DPP biosynthetic process" EXACT [] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0050993 ! dimethylallyl diphosphate metabolic process + +[Term] +id: GO:0050993 +name: dimethylallyl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dimethylallyl diphosphate." [GOC:ai] +synonym: "dimethylallyl diphosphate metabolism" EXACT [] +synonym: "dimethylallyl pyrophosphate metabolic process" EXACT [] +synonym: "dimethylallyl pyrophosphate metabolism" EXACT [] +synonym: "DPP metabolic process" EXACT [] +synonym: "DPP metabolism" EXACT [] +is_a: GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:0050994 +name: regulation of lipid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "regulation of lipid breakdown" EXACT [] +synonym: "regulation of lipid catabolism" EXACT [] +synonym: "regulation of lipid degradation" EXACT [] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0019216 ! regulation of lipid metabolic process +relationship: regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050995 +name: negative regulation of lipid catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "down regulation of lipid catabolic process" EXACT [] +synonym: "down-regulation of lipid catabolic process" EXACT [] +synonym: "downregulation of lipid catabolic process" EXACT [] +synonym: "inhibition of lipid catabolic process" NARROW [] +synonym: "negative regulation of lipid breakdown" EXACT [] +synonym: "negative regulation of lipid catabolism" EXACT [] +synonym: "negative regulation of lipid degradation" EXACT [] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: negatively_regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050996 +name: positive regulation of lipid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai] +synonym: "activation of lipid catabolic process" NARROW [] +synonym: "positive regulation of lipid breakdown" EXACT [] +synonym: "positive regulation of lipid catabolism" EXACT [] +synonym: "positive regulation of lipid degradation" EXACT [] +synonym: "stimulation of lipid catabolic process" NARROW [] +synonym: "up regulation of lipid catabolic process" EXACT [] +synonym: "up-regulation of lipid catabolic process" EXACT [] +synonym: "upregulation of lipid catabolic process" EXACT [] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: positively_regulates GO:0016042 ! lipid catabolic process + +[Term] +id: GO:0050997 +name: quaternary ammonium group binding +namespace: molecular_function +def: "Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai] +synonym: "quaternary amine binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0050998 +name: nitric-oxide synthase binding +namespace: molecular_function +def: "Binding to nitric-oxide synthase." [GOC:ai] +synonym: "NOS binding" EXACT [] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0050999 +name: regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "nitric-oxide synthase regulator" EXACT [] +synonym: "NOS regulator" EXACT [] +synonym: "regulation of NOS activity" EXACT [] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0051000 +name: positive regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "activation of nitric-oxide synthase activity" NARROW [] +synonym: "nitric-oxide synthase activator" EXACT [] +synonym: "NOS activator" EXACT [] +synonym: "positive regulation of NOS activity" EXACT [] +synonym: "stimulation of nitric-oxide synthase activity" NARROW [] +synonym: "up regulation of nitric-oxide synthase activity" EXACT [] +synonym: "up-regulation of nitric-oxide synthase activity" EXACT [] +synonym: "upregulation of nitric-oxide synthase activity" EXACT [] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0050999 ! regulation of nitric-oxide synthase activity + +[Term] +id: GO:0051001 +name: negative regulation of nitric-oxide synthase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme nitric-oxide synthase." [GOC:ai] +synonym: "down regulation of nitric-oxide synthase activity" EXACT [] +synonym: "down-regulation of nitric-oxide synthase activity" EXACT [] +synonym: "downregulation of nitric-oxide synthase activity" EXACT [] +synonym: "inhibition of nitric-oxide synthase activity" NARROW [] +synonym: "negative regulation of NOS activity" EXACT [] +synonym: "nitric-oxide synthase inhibitor" NARROW [] +synonym: "NOS inhibitor" NARROW [] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0050999 ! regulation of nitric-oxide synthase activity + +[Term] +id: GO:0051002 +name: ligase activity, forming nitrogen-metal bonds +namespace: molecular_function +def: "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6.-.-, GOC:mah] +xref: EC:6.6.-.- +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0051003 +name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes +namespace: molecular_function +def: "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-] +xref: EC:6.6.1.- +is_a: GO:0051002 ! ligase activity, forming nitrogen-metal bonds + +[Term] +id: GO:0051004 +name: regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that modulates the activity of the enzyme lipoprotein lipase." [GOC:ai] +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0051005 +name: negative regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme lipoprotein lipase." [GOC:ai] +synonym: "down regulation of lipoprotein lipase activity" EXACT [] +synonym: "down-regulation of lipoprotein lipase activity" EXACT [] +synonym: "downregulation of lipoprotein lipase activity" EXACT [] +synonym: "inhibition of lipoprotein lipase activity" NARROW [] +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0060192 ! negative regulation of lipase activity + +[Term] +id: GO:0051006 +name: positive regulation of lipoprotein lipase activity +namespace: biological_process +def: "Any process that activates or increases the activity of the enzyme lipoprotein lipase." [GOC:ai] +synonym: "activation of lipoprotein lipase activity" NARROW [] +synonym: "stimulation of lipoprotein lipase activity" NARROW [] +synonym: "up regulation of lipoprotein lipase activity" EXACT [] +synonym: "up-regulation of lipoprotein lipase activity" EXACT [] +synonym: "upregulation of lipoprotein lipase activity" EXACT [] +is_a: GO:0051004 ! regulation of lipoprotein lipase activity +is_a: GO:0061365 ! positive regulation of triglyceride lipase activity + +[Term] +id: GO:0051007 +name: squalene-hopene cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: squalene = hop-22(29)-ene." [EC:5.4.99.17] +synonym: "squalene mutase (cyclizing)" RELATED [EC:5.4.99.17] +synonym: "squalene:hopene cyclase activity" EXACT [PMID:18033581] +xref: EC:5.4.99.17 +xref: MetaCyc:5.4.99.17-RXN +xref: RHEA:17637 +is_a: GO:0016866 ! intramolecular transferase activity +is_a: GO:0034072 ! squalene cyclase activity + +[Term] +id: GO:0051008 +name: Hsp27 protein binding +namespace: molecular_function +def: "Binding to Hsp27 proteins, a lightweight heat shock protein." [GOC:ai] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0051009 +name: O-acetylhomoserine sulfhydrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27822] +xref: MetaCyc:ACETYLHOMOSER-CYS-RXN +xref: RHEA:27822 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0051010 +name: microtubule plus-end binding +namespace: molecular_function +def: "Binding to the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] +is_a: GO:0008017 ! microtubule binding + +[Term] +id: GO:0051011 +name: microtubule minus-end binding +namespace: molecular_function +def: "Binding to the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826] +is_a: GO:0008017 ! microtubule binding + +[Term] +id: GO:0051012 +name: microtubule sliding +namespace: biological_process +def: "The movement of one microtubule along another microtubule." [PMID:14557818, PMID:14614826] +synonym: "microtubule translocation" EXACT [] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0051013 +name: microtubule severing +namespace: biological_process +def: "The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends." [GOC:ai, PMID:27037673] +synonym: "microtubule severing activity" RELATED [] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0051014 +name: actin filament severing +namespace: biological_process +def: "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234] +synonym: "actin filament severing activity" RELATED [] +synonym: "barbed-end actin capping/severing activity" RELATED [] +synonym: "F-actin severing" EXACT [] +is_a: GO:0030029 ! actin filament-based process + +[Term] +id: GO:0051015 +name: actin filament binding +namespace: molecular_function +def: "Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] +synonym: "actin cross-linking activity" RELATED [] +synonym: "F-actin binding" EXACT [] +is_a: GO:0003779 ! actin binding +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0051016 +name: barbed-end actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "barbed-end actin capping activity" EXACT [] +synonym: "barbed-end F-actin capping activity" EXACT [] +synonym: "plus-end actin filament capping activity" EXACT [] +synonym: "plus-end F-actin capping activity" EXACT [] +is_a: GO:0051693 ! actin filament capping + +[Term] +id: GO:0051017 +name: actin filament bundle assembly +namespace: biological_process +alt_id: GO:0045011 +def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] +synonym: "actin bundling activity" RELATED [] +synonym: "actin cable assembly" RELATED [GOC:mah] +synonym: "actin cable formation" RELATED [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0061572 ! actin filament bundle organization + +[Term] +id: GO:0051018 +name: protein kinase A binding +namespace: molecular_function +def: "Binding to a protein kinase A." [GOC:ai] +comment: Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. +synonym: "PKA binding" EXACT [] +synonym: "protein kinase A anchoring activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051019 +name: mitogen-activated protein kinase binding +namespace: molecular_function +def: "Binding to a mitogen-activated protein kinase." [GOC:ai] +synonym: "MAP kinase binding" EXACT [] +synonym: "MAP-kinase anchoring activity" RELATED [] +synonym: "MAPK binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0051020 +name: GTPase binding +namespace: molecular_function +def: "Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0051021 +name: GDP-dissociation inhibitor binding +namespace: molecular_function +def: "Binding to a GDP-dissociation inhibitor protein." [GOC:ai] +synonym: "GDI binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051022 +name: Rho GDP-dissociation inhibitor binding +namespace: molecular_function +def: "Binding to a Rho GDP-dissociation inhibitor protein." [GOC:ai] +synonym: "Rho GDI binding" EXACT [] +is_a: GO:0051021 ! GDP-dissociation inhibitor binding + +[Term] +id: GO:0051026 +name: chiasma assembly +namespace: biological_process +def: "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [PMID:23396135] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007129 ! homologous chromosome pairing at meiosis +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:0051027 +name: DNA transport +namespace: biological_process +def: "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050657 ! nucleic acid transport + +[Term] +id: GO:0051028 +name: mRNA transport +namespace: biological_process +def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051029 +name: rRNA transport +namespace: biological_process +def: "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051030 +name: snRNA transport +namespace: biological_process +def: "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051031 +name: tRNA transport +namespace: biological_process +def: "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:0051032 +name: nucleic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai] +is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity +is_a: GO:0022884 ! macromolecule transmembrane transporter activity + +[Term] +id: GO:0051033 +name: RNA transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other." [GOC:ai] +xref: Reactome:R-HSA-203906 "Exportin complex translocates pre-miRNA to cytosol" +is_a: GO:0051032 ! nucleic acid transmembrane transporter activity + +[Term] +id: GO:0051034 +name: tRNA transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0051033 ! RNA transmembrane transporter activity + +[Term] +id: GO:0051035 +name: DNA transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai] +is_a: GO:0051032 ! nucleic acid transmembrane transporter activity + +[Term] +id: GO:0051036 +name: regulation of endosome size +namespace: biological_process +def: "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai] +synonym: "endosome enlargement" RELATED [] +is_a: GO:0097494 ! regulation of vesicle size + +[Term] +id: GO:0051037 +name: regulation of transcription involved in meiotic cell cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators] +synonym: "meiotic regulation of transcription" EXACT [] +synonym: "regulation of transcription, meiotic" EXACT [GOC:mah] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051038 +name: negative regulation of transcription involved in meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai] +synonym: "down regulation of transcription during meiosis" EXACT [GOC:mah] +synonym: "down-regulation of transcription during meiosis" EXACT [GOC:mah] +synonym: "downregulation of transcription during meiosis" EXACT [GOC:mah] +synonym: "inhibition of transcription during meiosis" NARROW [GOC:mah] +synonym: "meiotic repression of transcription" EXACT [] +synonym: "negative regulation of meiotic transcription" EXACT [] +synonym: "negative regulation of transcription, meiotic" EXACT [GOC:mah] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle + +[Term] +id: GO:0051039 +name: positive regulation of transcription involved in meiotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai] +synonym: "activation of transcription during meiosis" NARROW [GOC:mah] +synonym: "positive regulation of meiotic transcription" EXACT [] +synonym: "positive regulation of transcription, meiotic" EXACT [GOC:mah] +synonym: "stimulation of transcription during meiosis" NARROW [GOC:mah] +synonym: "up regulation of transcription during meiosis" EXACT [GOC:mah] +synonym: "up-regulation of transcription during meiosis" EXACT [GOC:mah] +synonym: "upregulation of transcription during meiosis" EXACT [GOC:mah] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle + +[Term] +id: GO:0051040 +name: regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules + +[Term] +id: GO:0051041 +name: positive regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] +synonym: "activation of calcium-independent cell-cell adhesion" NARROW [] +synonym: "stimulation of calcium-independent cell-cell adhesion" NARROW [] +synonym: "up regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "up-regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "upregulation of calcium-independent cell-cell adhesion" EXACT [] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion +relationship: positively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules + +[Term] +id: GO:0051042 +name: negative regulation of calcium-independent cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai] +synonym: "down regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "down-regulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "downregulation of calcium-independent cell-cell adhesion" EXACT [] +synonym: "inhibition of calcium-independent cell-cell adhesion" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0051040 ! regulation of calcium-independent cell-cell adhesion +relationship: negatively_regulates GO:0016338 ! calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules + +[Term] +id: GO:0051043 +name: regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051044 +name: positive regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai] +synonym: "activation of membrane protein ectodomain proteolysis" NARROW [] +synonym: "stimulation of membrane protein ectodomain proteolysis" NARROW [] +synonym: "up regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "up-regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "upregulation of membrane protein ectodomain proteolysis" EXACT [] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis +relationship: positively_regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051045 +name: negative regulation of membrane protein ectodomain proteolysis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai] +synonym: "down regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "down-regulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "downregulation of membrane protein ectodomain proteolysis" EXACT [] +synonym: "inhibition of membrane protein ectodomain proteolysis" NARROW [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0051043 ! regulation of membrane protein ectodomain proteolysis +relationship: negatively_regulates GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051046 +name: regulation of secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0046903 ! secretion + +[Term] +id: GO:0051047 +name: positive regulation of secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] +synonym: "activation of secretion" NARROW [] +synonym: "stimulation of secretion" NARROW [] +synonym: "up regulation of secretion" EXACT [] +synonym: "up-regulation of secretion" EXACT [] +synonym: "upregulation of secretion" EXACT [] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051050 ! positive regulation of transport +relationship: positively_regulates GO:0046903 ! secretion + +[Term] +id: GO:0051048 +name: negative regulation of secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai] +synonym: "down regulation of secretion" EXACT [] +synonym: "down-regulation of secretion" EXACT [] +synonym: "downregulation of secretion" EXACT [] +synonym: "inhibition of secretion" NARROW [] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051051 ! negative regulation of transport +relationship: negatively_regulates GO:0046903 ! secretion + +[Term] +id: GO:0051049 +name: regulation of transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +subset: goslim_yeast +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0006810 ! transport + +[Term] +id: GO:0051050 +name: positive regulation of transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of transport" NARROW [] +synonym: "stimulation of transport" NARROW [] +synonym: "up regulation of transport" EXACT [] +synonym: "up-regulation of transport" EXACT [] +synonym: "upregulation of transport" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051049 ! regulation of transport +relationship: positively_regulates GO:0006810 ! transport + +[Term] +id: GO:0051051 +name: negative regulation of transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of transport" EXACT [] +synonym: "down-regulation of transport" EXACT [] +synonym: "downregulation of transport" EXACT [] +synonym: "inhibition of transport" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051049 ! regulation of transport +relationship: negatively_regulates GO:0006810 ! transport + +[Term] +id: GO:0051052 +name: regulation of DNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +subset: goslim_yeast +synonym: "regulation of DNA metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051053 +name: negative regulation of DNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +synonym: "down regulation of DNA metabolic process" EXACT [] +synonym: "down-regulation of DNA metabolic process" EXACT [] +synonym: "downregulation of DNA metabolic process" EXACT [] +synonym: "inhibition of DNA metabolic process" NARROW [] +synonym: "negative regulation of DNA metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: negatively_regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051054 +name: positive regulation of DNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] +synonym: "activation of DNA metabolic process" NARROW [] +synonym: "positive regulation of DNA metabolism" EXACT [] +synonym: "stimulation of DNA metabolic process" NARROW [] +synonym: "up regulation of DNA metabolic process" EXACT [] +synonym: "up-regulation of DNA metabolic process" EXACT [] +synonym: "upregulation of DNA metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: positively_regulates GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0051055 +name: negative regulation of lipid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai] +synonym: "down regulation of lipid biosynthetic process" EXACT [] +synonym: "down-regulation of lipid biosynthetic process" EXACT [] +synonym: "downregulation of lipid biosynthetic process" EXACT [] +synonym: "inhibition of lipid biosynthetic process" NARROW [] +synonym: "negative regulation of lipid anabolism" EXACT [] +synonym: "negative regulation of lipid biosynthesis" EXACT [] +synonym: "negative regulation of lipid formation" EXACT [] +synonym: "negative regulation of lipid synthesis" EXACT [] +synonym: "negative regulation of lipogenesis" EXACT [GOC:sl] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0008610 ! lipid biosynthetic process + +[Term] +id: GO:0051056 +name: regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators] +synonym: "regulation of small GTPase-mediated signal transduction" EXACT [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051057 +name: positive regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] +synonym: "activation of small GTPase mediated signal transduction" NARROW [] +synonym: "positive regulation of small GTPase-mediated signal transduction" EXACT [] +synonym: "stimulation of small GTPase mediated signal transduction" NARROW [] +synonym: "up regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "up-regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "upregulation of small GTPase mediated signal transduction" EXACT [] +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051058 +name: negative regulation of small GTPase mediated signal transduction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai] +synonym: "down regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "down-regulation of small GTPase mediated signal transduction" EXACT [] +synonym: "downregulation of small GTPase mediated signal transduction" EXACT [] +synonym: "inhibition of small GTPase mediated signal transduction" NARROW [] +synonym: "negative regulation of small GTPase-mediated signal transduction" EXACT [] +is_a: GO:0051056 ! regulation of small GTPase mediated signal transduction +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0007264 ! small GTPase mediated signal transduction + +[Term] +id: GO:0051059 +name: NF-kappaB binding +namespace: molecular_function +def: "Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai] +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0051060 +name: pullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41] +synonym: "alpha-dextrin endo-1,6-alpha-glucosidase activity" EXACT [] +synonym: "amylopectin 6-glucanohydrolase activity" EXACT [] +synonym: "bacterial debranching enzyme" RELATED [EC:3.2.1.41] +synonym: "debranching enzyme activity" BROAD [EC:3.2.1.41] +synonym: "limit dextrinase" RELATED [] +synonym: "pullulan 6-glucanohydrolase activity" EXACT [] +synonym: "pullulan alpha-1,6-glucanohydrolase activity" RELATED [EC:3.2.1.41] +synonym: "R-enzyme" RELATED [EC:3.2.1.41] +xref: EC:3.2.1.41 +xref: MetaCyc:RXN-1824 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051061 +name: ADP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN] +synonym: "ADP reduction" RELATED [] +xref: MetaCyc:ADPREDUCT-RXN +xref: RHEA:28034 +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor + +[Term] +id: GO:0051062 +name: UDP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN] +synonym: "UDP reduction" RELATED [] +xref: MetaCyc:UDPREDUCT-RXN +xref: RHEA:28026 +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor + +[Term] +id: GO:0051063 +name: CDP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN] +synonym: "CDP reduction" RELATED [] +xref: MetaCyc:CDPREDUCT-RXN +is_a: GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor + +[Term] +id: GO:0051064 +name: TTP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] +synonym: "TTP reduction" RELATED [] +xref: EC:1.17.4.- +is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity + +[Term] +id: GO:0051065 +name: CTP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN] +synonym: "CTP reduction" RELATED [] +xref: EC:1.17.4.- +is_a: GO:0008998 ! ribonucleoside-triphosphate reductase activity + +[Term] +id: GO:0051066 +name: dihydrobiopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [PMID:2557335] +synonym: "6,7-dihydrobiopterin metabolic process" NARROW [CHEBI:20680] +synonym: "7,8-dihydrobiopterin metabolic process" NARROW [CHEBI:15375] +synonym: "dihydrobiopterin reduction" NARROW [] +synonym: "dihydropterin metabolic process" EXACT [CHEBI:38797] +synonym: "dihydropterin metabolism" EXACT [] +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:0051067 +name: dihydropteridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [PMID:2557335] +synonym: "6,7-dihydropteridine metabolic process" EXACT [PMID:19567870] +synonym: "dihydropteridine metabolism" EXACT [] +synonym: "dihydropteridine reduction" NARROW [] +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:0051068 +name: dihydrolipoamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464] +synonym: "dihydrolipoamide metabolism" EXACT [] +synonym: "dihydrolipoamide reduction" NARROW [] +synonym: "dihydrothioctamide metabolic process" EXACT [] +synonym: "dihydrothioctamide metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0051069 +name: galactomannan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/] +synonym: "galactomannan metabolism" EXACT [] +is_a: GO:0006080 ! substituted mannan metabolic process + +[Term] +id: GO:0051070 +name: galactomannan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] +synonym: "galactomannan anabolism" EXACT [] +synonym: "galactomannan biosynthesis" EXACT [] +synonym: "galactomannan formation" EXACT [] +synonym: "galactomannan synthesis" EXACT [] +is_a: GO:0000271 ! polysaccharide biosynthetic process +is_a: GO:0051069 ! galactomannan metabolic process + +[Term] +id: GO:0051071 +name: 4,6-pyruvylated galactose residue metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] +synonym: "4,6-pyruvylated galactose residue metabolism" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism" EXACT [] +synonym: "PvGal metabolic process" EXACT [] +synonym: "PvGal metabolism" EXACT [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0051072 +name: 4,6-pyruvylated galactose residue biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185] +synonym: "4,6-pyruvylated galactose residue anabolism" EXACT [] +synonym: "4,6-pyruvylated galactose residue biosynthesis" EXACT [] +synonym: "4,6-pyruvylated galactose residue formation" EXACT [] +synonym: "4,6-pyruvylated galactose residue synthesis" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis" EXACT [] +synonym: "4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process" EXACT [] +synonym: "PvGal biosynthesis" EXACT [] +synonym: "PvGal biosynthetic process" EXACT [] +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process + +[Term] +id: GO:0051073 +name: adenosylcobinamide-GDP ribazoletransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN] +synonym: "adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity" RELATED [EC:2.7.8.26] +synonym: "cobalamin (5'-phosphate) synthase activity" RELATED [EC:2.7.8.26] +synonym: "cobalamin synthase activity" EXACT [] +synonym: "cobalamin-5'-phosphate synthase activity" RELATED [EC:2.7.8.26] +synonym: "CobS" RELATED [EC:2.7.8.26] +xref: EC:2.7.8.26 +xref: MetaCyc:COBALAMINSYN-RXN +xref: RHEA:16049 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0051074 +name: obsolete protein tetramerization activity +namespace: molecular_function +def: "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] +comment: This term was made obsolete because it represents a process. +synonym: "protein tetramerization activity" EXACT [] +is_obsolete: true +replaced_by: GO:0051262 + +[Term] +id: GO:0051075 +name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872] +synonym: "S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity" EXACT [] +xref: EC:2.4.99.17 +xref: RHEA:32155 +is_a: GO:0016757 ! glycosyltransferase activity +is_a: GO:0016853 ! isomerase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0051077 +name: secondary cell septum +namespace: cellular_component +def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] +synonym: "secondary septum" BROAD [] +is_a: GO:0000935 ! division septum + +[Term] +id: GO:0051078 +name: meiotic nuclear membrane disassembly +namespace: biological_process +def: "The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs." [GOC:bf] +synonym: "meiotic nuclear envelope breakdown" RELATED [] +synonym: "meiotic nuclear envelope catabolism" RELATED [] +synonym: "meiotic nuclear envelope degradation" RELATED [] +synonym: "meiotic nuclear envelope disassembly" RELATED [] +is_a: GO:0051081 ! nuclear membrane disassembly +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0051079 +name: meiosis I nuclear membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear membranes during the first division of meiosis." [GOC:bf] +synonym: "meiosis I nuclear envelope breakdown" RELATED [] +synonym: "meiosis I nuclear envelope catabolism" RELATED [] +synonym: "meiosis I nuclear envelope degradation" RELATED [] +synonym: "meiosis I nuclear envelope disassembly" RELATED [] +is_a: GO:0051078 ! meiotic nuclear membrane disassembly +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0051080 +name: meiosis II nuclear membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear membranes during the second division of meiosis." [GOC:bf] +synonym: "meiosis II nuclear envelope breakdown" RELATED [] +synonym: "meiosis II nuclear envelope catabolism" RELATED [] +synonym: "meiosis II nuclear envelope degradation" RELATED [] +synonym: "meiosis II nuclear envelope disassembly" RELATED [] +is_a: GO:0051078 ! meiotic nuclear membrane disassembly +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0051081 +name: nuclear membrane disassembly +namespace: biological_process +def: "The controlled breakdown of the nuclear membranes, for example during cellular division." [GOC:ai] +synonym: "nuclear envelope breakdown" RELATED [] +synonym: "nuclear envelope catabolism" RELATED [] +synonym: "nuclear envelope degradation" RELATED [] +synonym: "nuclear envelope disassembly" RELATED [] +is_a: GO:0030397 ! membrane disassembly +is_a: GO:0071763 ! nuclear membrane organization + +[Term] +id: GO:0051082 +name: unfolded protein binding +namespace: molecular_function +def: "Binding to an unfolded protein." [GOC:ai] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_yeast +synonym: "chaperone activity" BROAD [] +xref: Reactome:R-HSA-9683772 "Trimmed spike protein binds to calnexin" +xref: Reactome:R-HSA-9694337 "Trimmed spike protein binds to calnexin" +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051083 +name: 'de novo' cotranslational protein folding +namespace: biological_process +alt_id: GO:0006444 +def: "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb] +synonym: "'de novo' co-translational protein folding" EXACT [] +synonym: "multidomain protein assembly" EXACT [] +synonym: "nascent polypeptide association" EXACT [] +is_a: GO:0006458 ! 'de novo' protein folding + +[Term] +id: GO:0051084 +name: 'de novo' posttranslational protein folding +namespace: biological_process +def: "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb] +synonym: "'de novo' post-translational protein folding" EXACT [] +is_a: GO:0006458 ! 'de novo' protein folding + +[Term] +id: GO:0051085 +name: chaperone cofactor-dependent protein refolding +namespace: biological_process +alt_id: GO:0070389 +def: "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb] +synonym: "chaperone co-factor-dependent protein folding" RELATED [] +synonym: "chaperone co-factor-dependent protein refolding" EXACT [] +synonym: "chaperone cofactor-dependent 'de novo' protein folding" EXACT [GOC:mah] +synonym: "chaperone cofactor-dependent protein folding" EXACT [GOC:rb] +synonym: "chaperone mediated protein folding requiring cofactor" RELATED [] +is_a: GO:0051084 ! 'de novo' posttranslational protein folding +is_a: GO:0061077 ! chaperone-mediated protein folding + +[Term] +id: GO:0051086 +name: chaperone mediated protein folding independent of cofactor +namespace: biological_process +def: "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb] +synonym: "chaperone cofactor-independent protein folding" EXACT [GOC:rb] +is_a: GO:0051084 ! 'de novo' posttranslational protein folding +is_a: GO:0061077 ! chaperone-mediated protein folding + +[Term] +id: GO:0051087 +name: chaperone binding +namespace: molecular_function +def: "Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [PMID:10585443] +synonym: "chaperone protein binding" EXACT [] +synonym: "co-chaperone activity" RELATED [] +synonym: "co-chaperonin activity" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051088 +name: obsolete PMA-inducible membrane protein ectodomain proteolysis +namespace: biological_process +def: "OBSOLETE. The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508] +comment: This term was obsoleted because it represents an assay to induce PKC. +is_obsolete: true + +[Term] +id: GO:0051089 +name: constitutive protein ectodomain proteolysis +namespace: biological_process +def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508] +is_a: GO:0006509 ! membrane protein ectodomain proteolysis + +[Term] +id: GO:0051090 +name: regulation of DNA-binding transcription factor activity +namespace: biological_process +alt_id: GO:1904167 +alt_id: GO:2000823 +def: "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] +synonym: "regulation of androgen receptor activity" NARROW [] +synonym: "regulation of DNA binding transcription factor activity" EXACT [] +synonym: "regulation of sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "regulation of thyroid hormone receptor activity" NARROW [] +synonym: "regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0051091 +name: positive regulation of DNA-binding transcription factor activity +namespace: biological_process +alt_id: GO:1904169 +def: "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai] +synonym: "activation of transcription factor activity" NARROW [] +synonym: "positive regulation of DNA binding transcription factor activity" EXACT [] +synonym: "positive regulation of sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "positive regulation of thyroid hormone receptor activity" NARROW [] +synonym: "positive regulation of transcription factor activity" BROAD [GOC:dph, GOC:tb] +synonym: "stimulation of transcription factor activity" NARROW [] +synonym: "up regulation of transcription factor activity" EXACT [] +synonym: "up-regulation of transcription factor activity" EXACT [] +synonym: "upregulation of transcription factor activity" EXACT [] +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0051092 +name: positive regulation of NF-kappaB transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030] +synonym: "activation of NF-kappaB" EXACT [] +synonym: "activation of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] +synonym: "NF-kappaB activation" EXACT [] +is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity + +[Term] +id: GO:0051093 +name: negative regulation of developmental process +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] +synonym: "down regulation of developmental process" EXACT [] +synonym: "down-regulation of developmental process" EXACT [] +synonym: "downregulation of developmental process" EXACT [] +synonym: "inhibition of developmental process" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050793 ! regulation of developmental process +relationship: negatively_regulates GO:0032502 ! developmental process + +[Term] +id: GO:0051094 +name: positive regulation of developmental process +namespace: biological_process +def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] +synonym: "activation of developmental process" NARROW [] +synonym: "stimulation of developmental process" NARROW [] +synonym: "up regulation of developmental process" EXACT [] +synonym: "up-regulation of developmental process" EXACT [] +synonym: "upregulation of developmental process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0050793 ! regulation of developmental process +relationship: positively_regulates GO:0032502 ! developmental process + +[Term] +id: GO:0051095 +name: regulation of helicase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of helicase activity." [GOC:ai] +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051096 +name: positive regulation of helicase activity +namespace: biological_process +def: "Any process that activates or increases the activity of a helicase." [GOC:ai] +synonym: "activation of helicase activity" NARROW [] +synonym: "stimulation of helicase activity" NARROW [] +synonym: "up regulation of helicase activity" EXACT [] +synonym: "up-regulation of helicase activity" EXACT [] +synonym: "upregulation of helicase activity" EXACT [] +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051095 ! regulation of helicase activity + +[Term] +id: GO:0051097 +name: negative regulation of helicase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of a helicase." [GOC:ai] +synonym: "down regulation of helicase activity" EXACT [] +synonym: "down-regulation of helicase activity" EXACT [] +synonym: "downregulation of helicase activity" EXACT [] +synonym: "inhibition of helicase activity" NARROW [] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051095 ! regulation of helicase activity + +[Term] +id: GO:0051098 +name: regulation of binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:0051099 +name: positive regulation of binding +namespace: biological_process +def: "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +synonym: "activation of binding" NARROW [] +synonym: "stimulation of binding" NARROW [] +synonym: "up regulation of binding" EXACT [] +synonym: "up-regulation of binding" EXACT [] +synonym: "upregulation of binding" EXACT [] +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051100 +name: negative regulation of binding +namespace: biological_process +def: "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai] +synonym: "down regulation of binding" EXACT [] +synonym: "down-regulation of binding" EXACT [] +synonym: "downregulation of binding" EXACT [] +synonym: "inhibition of binding" NARROW [] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051101 +name: regulation of DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:0051102 +name: DNA ligation involved in DNA recombination +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai] +synonym: "DNA ligation during DNA recombination" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0051103 +name: DNA ligation involved in DNA repair +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai] +synonym: "DNA ligation during DNA repair" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:0051104 +name: DNA-dependent DNA replication DNA ligation +namespace: biological_process +def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb] +synonym: "DNA ligation during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] +synonym: "DNA ligation involved in DNA-dependent DNA replication" EXACT [] +is_a: GO:0006266 ! DNA ligation +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0051105 +name: regulation of DNA ligation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051106 +name: positive regulation of DNA ligation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +synonym: "activation of DNA ligation" NARROW [] +synonym: "stimulation of DNA ligation" NARROW [] +synonym: "up regulation of DNA ligation" EXACT [] +synonym: "up-regulation of DNA ligation" EXACT [] +synonym: "upregulation of DNA ligation" EXACT [] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0051105 ! regulation of DNA ligation +relationship: positively_regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051107 +name: negative regulation of DNA ligation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai] +synonym: "down regulation of DNA ligation" EXACT [] +synonym: "down-regulation of DNA ligation" EXACT [] +synonym: "downregulation of DNA ligation" EXACT [] +synonym: "inhibition of DNA ligation" NARROW [] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0051105 ! regulation of DNA ligation +relationship: negatively_regulates GO:0006266 ! DNA ligation + +[Term] +id: GO:0051108 +name: carnitine-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN] +synonym: "carnitine synthetase activity" EXACT [] +synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] +xref: MetaCyc:DCARNCOALIG-RXN +xref: RHEA:30543 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0051109 +name: crotonobetaine-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN] +synonym: "crotonobetaine-CoA synthase activity" EXACT [] +synonym: "crotonobetaine/carnitine-CoA ligase activity" BROAD [] +xref: MetaCyc:CROTCOALIG-RXN +xref: RHEA:30079 +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0051110 +name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine +namespace: biological_process +def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] +xref: RESID:AA0372 +is_a: GO:0051114 ! peptidyl-histidine uridylylation + +[Term] +id: GO:0051111 +name: peptidyl-histidine adenylylation +namespace: biological_process +def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371] +xref: RESID:AA0371 +is_a: GO:0018117 ! protein adenylylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0051112 +name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine +namespace: biological_process +def: "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] +xref: RESID:AA0371 +is_a: GO:0051111 ! peptidyl-histidine adenylylation + +[Term] +id: GO:0051113 +name: obsolete enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine +namespace: biological_process +def: "OBSOLETE. The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:15182206. +xref: RESID:AA0371 +is_obsolete: true + +[Term] +id: GO:0051114 +name: peptidyl-histidine uridylylation +namespace: biological_process +def: "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372] +xref: RESID:AA0372 +is_a: GO:0018177 ! protein uridylylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0051115 +name: obsolete enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine +namespace: biological_process +def: "OBSOLETE. The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372] +comment: This term was obsoleted because it represents a reaction intermediate, not a biological process, see PMID:8794735. +xref: RESID:AA0372 +is_obsolete: true +consider: GO:0017103 + +[Term] +id: GO:0051116 +name: cobaltochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15341] +synonym: "CobN-CobST" RELATED [EC:6.6.1.2] +synonym: "CobNST" NARROW [] +synonym: "hydrogenobyrinic acid a,c-diamide cobaltochelatase activity" EXACT [] +synonym: "hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)" RELATED [EC:6.6.1.2] +xref: EC:6.6.1.2 +xref: KEGG_REACTION:R05227 +xref: MetaCyc:R342-RXN +xref: RHEA:15341 +is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes + +[Term] +id: GO:0051117 +name: ATPase binding +namespace: molecular_function +def: "Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0051118 +name: glucan endo-1,3-alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59] +synonym: "1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.59] +synonym: "cariogenanase activity" RELATED [EC:3.2.1.59] +synonym: "cariogenase activity" RELATED [EC:3.2.1.59] +synonym: "endo-(1->3)-alpha-glucanase activity" RELATED [EC:3.2.1.59] +synonym: "endo-1,3-alpha-D-glucanase activity" RELATED [EC:3.2.1.59] +synonym: "endo-1,3-alpha-glucanase activity" RELATED [EC:3.2.1.59] +synonym: "mutanase activity" RELATED [EC:3.2.1.59] +xref: EC:3.2.1.59 +xref: MetaCyc:3.2.1.59-RXN +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0051119 +name: sugar transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +synonym: "sugar/polyol channel activity" NARROW [] +xref: Reactome:R-HSA-428779 "GLUT7 and GLUT11 transport glucose and fructose" +xref: Reactome:R-HSA-8875902 "SLC45A3 transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8876319 "SLC50A1 transports Glc from cytosol to extracellular region" +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity + +[Term] +id: GO:0051120 +name: hepoxilin A3 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652] +xref: Reactome:R-HSA-2161794 "Arachidonic acid is converted to HXA3/B3 by ALOX12" +xref: Reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3" +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0051121 +name: hepoxilin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652] +synonym: "hepoxilin metabolism" EXACT [] +is_a: GO:0001676 ! long-chain fatty acid metabolic process + +[Term] +id: GO:0051122 +name: hepoxilin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai] +synonym: "hepoxilin anabolism" EXACT [] +synonym: "hepoxilin biosynthesis" EXACT [] +synonym: "hepoxilin formation" EXACT [] +synonym: "hepoxilin synthesis" EXACT [] +is_a: GO:0042759 ! long-chain fatty acid biosynthetic process +is_a: GO:0051121 ! hepoxilin metabolic process + +[Term] +id: GO:0051123 +name: RNA polymerase II preinitiation complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047] +synonym: "RNA polymerase II transcription PIC biosynthesis" EXACT [] +synonym: "RNA polymerase II transcription PIC formation" EXACT [] +synonym: "RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] +synonym: "RNA polymerase II transcriptional preinitiation complex formation" EXACT [] +is_a: GO:0070897 ! transcription preinitiation complex assembly +relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0051124 +name: synaptic assembly at neuromuscular junction +namespace: biological_process +def: "The assembly of a synapse at a neuromuscular junction." [PMID:20215342] +synonym: "cholinergic synaptogenesis" RELATED [] +synonym: "synaptic growth at neuromuscular junction" RELATED [] +is_a: GO:0007416 ! synapse assembly +is_a: GO:0007528 ! neuromuscular junction development +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0051125 +name: regulation of actin nucleation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +is_a: GO:0110053 ! regulation of actin filament organization +relationship: regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051126 +name: negative regulation of actin nucleation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +synonym: "down regulation of actin nucleation" EXACT [] +synonym: "down-regulation of actin nucleation" EXACT [] +synonym: "downregulation of actin nucleation" EXACT [] +synonym: "inhibition of actin nucleation" NARROW [] +is_a: GO:0051125 ! regulation of actin nucleation +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051127 +name: positive regulation of actin nucleation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai] +synonym: "activation of actin nucleation" NARROW [] +synonym: "stimulation of actin nucleation" NARROW [] +synonym: "up regulation of actin nucleation" EXACT [] +synonym: "up-regulation of actin nucleation" EXACT [] +synonym: "upregulation of actin nucleation" EXACT [] +is_a: GO:0051125 ! regulation of actin nucleation +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0045010 ! actin nucleation + +[Term] +id: GO:0051128 +name: regulation of cellular component organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +synonym: "regulation of cell organisation" RELATED [GOC:mah] +synonym: "regulation of cell organization" RELATED [GOC:mah] +synonym: "regulation of cellular component organisation" EXACT [] +synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051129 +name: negative regulation of cellular component organization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +synonym: "down regulation of cell organization" EXACT [] +synonym: "down-regulation of cell organization" EXACT [] +synonym: "downregulation of cell organization" EXACT [] +synonym: "inhibition of cell organization" NARROW [] +synonym: "negative regulation of cell organisation" RELATED [GOC:mah] +synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: negatively_regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051130 +name: positive regulation of cellular component organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] +synonym: "activation of cell organization" NARROW [] +synonym: "positive regulation of cell organisation" EXACT [] +synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] +synonym: "stimulation of cell organization" NARROW [] +synonym: "up regulation of cell organization" EXACT [] +synonym: "up-regulation of cell organization" EXACT [] +synonym: "upregulation of cell organization" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: positively_regulates GO:0016043 ! cellular component organization + +[Term] +id: GO:0051131 +name: chaperone-mediated protein complex assembly +namespace: biological_process +alt_id: GO:0034619 +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai] +synonym: "cellular chaperone-mediated protein complex assembly" EXACT [] +synonym: "chaperone activity" RELATED [] +synonym: "protein complex assembly, multichaperone pathway" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0051132 +name: NK T cell activation +namespace: biological_process +def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426] +comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments. +synonym: "natural killer T cell activation" EXACT [] +synonym: "natural T cell activation" EXACT [] +synonym: "NK T lymphocyte activation" EXACT [] +synonym: "NK T-cell activation" EXACT [] +synonym: "NK T-lymphocyte activation" EXACT [] +synonym: "NKT cell activation" EXACT [] +synonym: "NT cell activation" EXACT [] +is_a: GO:0046631 ! alpha-beta T cell activation + +[Term] +id: GO:0051133 +name: regulation of NK T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "regulation of natural killer T cell activation" EXACT [] +synonym: "regulation of natural T cell activation" EXACT [] +synonym: "regulation of NK T lymphocyte activation" EXACT [] +synonym: "regulation of NK T-cell activation" EXACT [] +synonym: "regulation of NK T-lymphocyte activation" EXACT [] +synonym: "regulation of NKT cell activation" EXACT [] +synonym: "regulation of NT cell activation" EXACT [] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051134 +name: negative regulation of NK T cell activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "down regulation of NK T cell activation" EXACT [] +synonym: "down-regulation of NK T cell activation" EXACT [] +synonym: "downregulation of NK T cell activation" EXACT [] +synonym: "inhibition of NK T cell activation" NARROW [] +synonym: "negative regulation of natural killer T cell activation" EXACT [] +synonym: "negative regulation of natural T cell activation" EXACT [] +synonym: "negative regulation of NK T lymphocyte activation" EXACT [] +synonym: "negative regulation of NK T-cell activation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte activation" EXACT [] +synonym: "negative regulation of NKT cell activation" EXACT [] +synonym: "negative regulation of NT cell activation" EXACT [] +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:0051133 ! regulation of NK T cell activation +relationship: negatively_regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051135 +name: positive regulation of NK T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "activation of NK T cell activation" NARROW [] +synonym: "positive regulation of natural killer T cell activation" EXACT [] +synonym: "positive regulation of natural T cell activation" EXACT [] +synonym: "positive regulation of NK T lymphocyte activation" EXACT [] +synonym: "positive regulation of NK T-cell activation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte activation" EXACT [] +synonym: "positive regulation of NKT cell activation" EXACT [] +synonym: "positive regulation of NT cell activation" EXACT [] +synonym: "stimulation of NK T cell activation" NARROW [] +synonym: "up regulation of NK T cell activation" EXACT [] +synonym: "up-regulation of NK T cell activation" EXACT [] +synonym: "upregulation of NK T cell activation" EXACT [] +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:0051133 ! regulation of NK T cell activation +relationship: positively_regulates GO:0051132 ! NK T cell activation + +[Term] +id: GO:0051136 +name: regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "regulation of natural killer T cell differentiation" EXACT [] +synonym: "regulation of natural T cell differentiation" EXACT [] +synonym: "regulation of NK T cell development" RELATED [GOC:add] +synonym: "regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "regulation of NK T-cell differentiation" EXACT [] +synonym: "regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "regulation of NKT cell differentiation" EXACT [] +synonym: "regulation of NT cell differentiation" EXACT [] +is_a: GO:0046637 ! regulation of alpha-beta T cell differentiation +relationship: regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051137 +name: negative regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "down regulation of NK T cell differentiation" EXACT [] +synonym: "down-regulation of NK T cell differentiation" EXACT [] +synonym: "downregulation of NK T cell differentiation" EXACT [] +synonym: "inhibition of NK T cell differentiation" NARROW [] +synonym: "negative regulation of natural killer T cell differentiation" EXACT [] +synonym: "negative regulation of natural T cell differentiation" EXACT [] +synonym: "negative regulation of NK T cell development" RELATED [GOC:add] +synonym: "negative regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "negative regulation of NK T-cell differentiation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "negative regulation of NKT cell differentiation" EXACT [] +synonym: "negative regulation of NT cell differentiation" EXACT [] +is_a: GO:0046639 ! negative regulation of alpha-beta T cell differentiation +is_a: GO:0051136 ! regulation of NK T cell differentiation +relationship: negatively_regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051138 +name: positive regulation of NK T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "activation of NK T cell differentiation" NARROW [] +synonym: "positive regulation of natural killer T cell differentiation" EXACT [] +synonym: "positive regulation of natural T cell differentiation" EXACT [] +synonym: "positive regulation of NK T cell development" RELATED [GOC:add] +synonym: "positive regulation of NK T lymphocyte differentiation" EXACT [] +synonym: "positive regulation of NK T-cell differentiation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte differentiation" EXACT [] +synonym: "positive regulation of NKT cell differentiation" EXACT [] +synonym: "positive regulation of NT cell differentiation" EXACT [] +synonym: "stimulation of NK T cell differentiation" NARROW [] +synonym: "up regulation of NK T cell differentiation" EXACT [] +synonym: "up-regulation of NK T cell differentiation" EXACT [] +synonym: "upregulation of NK T cell differentiation" EXACT [] +is_a: GO:0046638 ! positive regulation of alpha-beta T cell differentiation +is_a: GO:0051136 ! regulation of NK T cell differentiation +relationship: positively_regulates GO:0001865 ! NK T cell differentiation + +[Term] +id: GO:0051139 +name: metal ion:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg] +synonym: "metal ion:hydrogen antiporter activity" EXACT [] +xref: Reactome:R-HSA-435171 "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages" +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity +is_a: GO:0046873 ! metal ion transmembrane transporter activity + +[Term] +id: GO:0051140 +name: regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "regulation of natural killer T cell proliferation" EXACT [] +synonym: "regulation of natural T cell proliferation" EXACT [] +synonym: "regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "regulation of NK T-cell proliferation" EXACT [] +synonym: "regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "regulation of NKT cell proliferation" EXACT [] +synonym: "regulation of NT cell proliferation" EXACT [] +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +is_a: GO:0051133 ! regulation of NK T cell activation +relationship: regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051141 +name: negative regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "down regulation of NK T cell proliferation" EXACT [] +synonym: "down-regulation of NK T cell proliferation" EXACT [] +synonym: "downregulation of NK T cell proliferation" EXACT [] +synonym: "inhibition of NK T cell proliferation" NARROW [] +synonym: "negative regulation of natural killer T cell proliferation" EXACT [] +synonym: "negative regulation of natural T cell proliferation" EXACT [] +synonym: "negative regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "negative regulation of NK T-cell proliferation" EXACT [] +synonym: "negative regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "negative regulation of NKT cell proliferation" EXACT [] +synonym: "negative regulation of NT cell proliferation" EXACT [] +is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation +is_a: GO:0051134 ! negative regulation of NK T cell activation +is_a: GO:0051140 ! regulation of NK T cell proliferation +relationship: negatively_regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051142 +name: positive regulation of NK T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426] +synonym: "activation of NK T cell proliferation" NARROW [] +synonym: "positive regulation of natural killer T cell proliferation" EXACT [] +synonym: "positive regulation of natural T cell proliferation" EXACT [] +synonym: "positive regulation of NK T lymphocyte proliferation" EXACT [] +synonym: "positive regulation of NK T-cell proliferation" EXACT [] +synonym: "positive regulation of NK T-lymphocyte proliferation" EXACT [] +synonym: "positive regulation of NKT cell proliferation" EXACT [] +synonym: "positive regulation of NT cell proliferation" EXACT [] +synonym: "stimulation of NK T cell proliferation" NARROW [] +synonym: "up regulation of NK T cell proliferation" EXACT [] +synonym: "up-regulation of NK T cell proliferation" EXACT [] +synonym: "upregulation of NK T cell proliferation" EXACT [] +is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation +is_a: GO:0051135 ! positive regulation of NK T cell activation +is_a: GO:0051140 ! regulation of NK T cell proliferation +relationship: positively_regulates GO:0001866 ! NK T cell proliferation + +[Term] +id: GO:0051143 +name: propanediol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [PMID:15995211] +synonym: "1,2-dihydroxypropane metabolic process" EXACT [] +synonym: "1,2-dihydroxypropane metabolism" EXACT [] +synonym: "propanediol metabolism" EXACT [] +synonym: "propylene glycol metabolic process" EXACT [] +synonym: "propylene glycol metabolism" EXACT [] +is_a: GO:0042844 ! glycol metabolic process + +[Term] +id: GO:0051144 +name: propanediol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai] +synonym: "1,2-dihydroxypropane catabolic process" EXACT [] +synonym: "1,2-dihydroxypropane catabolism" EXACT [] +synonym: "propanediol breakdown" EXACT [] +synonym: "propanediol catabolism" EXACT [] +synonym: "propanediol degradation" EXACT [] +synonym: "propylene glycol catabolic process" EXACT [] +synonym: "propylene glycol catabolism" EXACT [] +is_a: GO:0042846 ! glycol catabolic process +is_a: GO:0051143 ! propanediol metabolic process + +[Term] +id: GO:0051145 +name: smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai] +synonym: "nonstriated muscle cell differentiation" EXACT [] +is_a: GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051146 +name: striated muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai] +synonym: "voluntary muscle cell differentiation" NARROW [] +is_a: GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051147 +name: regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051148 +name: negative regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +synonym: "down regulation of muscle cell differentiation" EXACT [] +synonym: "down-regulation of muscle cell differentiation" EXACT [] +synonym: "downregulation of muscle cell differentiation" EXACT [] +synonym: "inhibition of muscle cell differentiation" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: negatively_regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051149 +name: positive regulation of muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai] +synonym: "activation of muscle cell differentiation" NARROW [] +synonym: "stimulation of muscle cell differentiation" NARROW [] +synonym: "up regulation of muscle cell differentiation" EXACT [] +synonym: "up-regulation of muscle cell differentiation" EXACT [] +synonym: "upregulation of muscle cell differentiation" EXACT [] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: positively_regulates GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0051150 +name: regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051151 +name: negative regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +synonym: "down regulation of smooth muscle cell differentiation" EXACT [] +synonym: "down-regulation of smooth muscle cell differentiation" EXACT [] +synonym: "downregulation of smooth muscle cell differentiation" EXACT [] +synonym: "inhibition of smooth muscle cell differentiation" NARROW [] +is_a: GO:0051148 ! negative regulation of muscle cell differentiation +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: negatively_regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051152 +name: positive regulation of smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai] +synonym: "activation of smooth muscle cell differentiation" NARROW [] +synonym: "stimulation of smooth muscle cell differentiation" NARROW [] +synonym: "up regulation of smooth muscle cell differentiation" EXACT [] +synonym: "up-regulation of smooth muscle cell differentiation" EXACT [] +synonym: "upregulation of smooth muscle cell differentiation" EXACT [] +is_a: GO:0051149 ! positive regulation of muscle cell differentiation +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: positively_regulates GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:0051153 +name: regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +is_a: GO:0051147 ! regulation of muscle cell differentiation +relationship: regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051154 +name: negative regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +synonym: "down regulation of striated muscle cell differentiation" EXACT [] +synonym: "down-regulation of striated muscle cell differentiation" EXACT [] +synonym: "downregulation of striated muscle cell differentiation" EXACT [] +synonym: "inhibition of striated muscle cell differentiation" NARROW [] +is_a: GO:0051148 ! negative regulation of muscle cell differentiation +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +relationship: negatively_regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051155 +name: positive regulation of striated muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai] +synonym: "activation of striated muscle cell differentiation" NARROW [] +synonym: "stimulation of striated muscle cell differentiation" NARROW [] +synonym: "up regulation of striated muscle cell differentiation" EXACT [] +synonym: "up-regulation of striated muscle cell differentiation" EXACT [] +synonym: "upregulation of striated muscle cell differentiation" EXACT [] +is_a: GO:0051149 ! positive regulation of muscle cell differentiation +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0051156 +name: glucose 6-phosphate metabolic process +namespace: biological_process +alt_id: GO:0006010 +def: "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] +synonym: "glucose 6-phosphate metabolism" EXACT [] +synonym: "glucose 6-phosphate utilization" RELATED [GOC:mah] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0051157 +name: arabitol catabolic process +namespace: biological_process +alt_id: GO:0019591 +def: "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "arabitol breakdown" EXACT [] +synonym: "arabitol catabolism" EXACT [] +synonym: "arabitol degradation" EXACT [] +synonym: "arabitol utilization" RELATED [GOC:mah] +is_a: GO:0019527 ! pentitol catabolic process +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051158 +name: L-arabitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "L-arabitol breakdown" EXACT [] +synonym: "L-arabitol catabolism" EXACT [] +synonym: "L-arabitol degradation" EXACT [] +is_a: GO:0051157 ! arabitol catabolic process +is_a: GO:0051162 ! L-arabitol metabolic process + +[Term] +id: GO:0051159 +name: D-arabitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] +synonym: "D-arabitol breakdown" EXACT [] +synonym: "D-arabitol catabolism" EXACT [] +synonym: "D-arabitol degradation" EXACT [] +is_a: GO:0051157 ! arabitol catabolic process +is_a: GO:0051163 ! D-arabitol metabolic process + +[Term] +id: GO:0051160 +name: L-xylitol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai] +synonym: "L-xylitol breakdown" EXACT [] +synonym: "L-xylitol catabolism" EXACT [] +synonym: "L-xylitol degradation" EXACT [] +is_a: GO:0019527 ! pentitol catabolic process +is_a: GO:0051164 ! L-xylitol metabolic process + +[Term] +id: GO:0051161 +name: arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "arabitol metabolism" EXACT [] +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0051162 +name: L-arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732] +synonym: "L-arabitol metabolism" EXACT [] +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051163 +name: D-arabitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] +synonym: "D-arabitol metabolism" EXACT [] +is_a: GO:0051161 ! arabitol metabolic process + +[Term] +id: GO:0051164 +name: L-xylitol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai] +synonym: "L-xylitol metabolism" EXACT [] +is_a: GO:0019519 ! pentitol metabolic process + +[Term] +id: GO:0051165 +name: 2,5-dihydroxypyridine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2,5-dihydroxypyridine." [GOC:ai] +synonym: "2,5-dihydroxypyridine metabolism" EXACT [] +synonym: "pyridine-2,5-diol metabolic process" EXACT [CHEBI:16364] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0051166 +name: 2,5-dihydroxypyridine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [GOC:ai] +synonym: "2,5-dihydroxypyridine breakdown" EXACT [] +synonym: "2,5-dihydroxypyridine catabolism" EXACT [] +synonym: "2,5-dihydroxypyridine degradation" EXACT [] +synonym: "pyridine-2,5-diol catabolic process" EXACT [CHEBI:16364] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0051165 ! 2,5-dihydroxypyridine metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0051167 +name: xylulose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544] +synonym: "D-xylulose 5-phosphate metabolic process" EXACT [] +synonym: "D-xylulose 5-phosphate metabolism" EXACT [] +synonym: "D-xylulose-5-phosphate metabolic process" EXACT [] +synonym: "D-xylulose-5-phosphate metabolism" EXACT [] +synonym: "xylulose 5-phosphate metabolism" EXACT [] +synonym: "xylulose-5-phosphate metabolic process" EXACT [] +synonym: "xylulose-5-phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0051168 +name: nuclear export +namespace: biological_process +def: "The directed movement of substances out of the nucleus." [GOC:ai] +synonym: "export from nucleus" EXACT [] +synonym: "nucleus export" EXACT [] +synonym: "substance nuclear export" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0051169 +name: nuclear transport +namespace: biological_process +def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] +subset: goslim_yeast +synonym: "nucleus transport" EXACT [] +xref: Wikipedia:Nuclear_transport +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0051170 +name: import into nucleus +namespace: biological_process +alt_id: GO:1902593 +def: "The directed movement of substances into the nucleus." [GOC:ai] +synonym: "nuclear import" EXACT [] +synonym: "single organism nuclear import" EXACT [GOC:TermGenie] +synonym: "single-organism nuclear import" RELATED [] +synonym: "substance nuclear import" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0051171 +name: regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "regulation of nitrogen metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051172 +name: negative regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +synonym: "down regulation of nitrogen metabolic process" EXACT [] +synonym: "down-regulation of nitrogen metabolic process" EXACT [] +synonym: "downregulation of nitrogen metabolic process" EXACT [] +synonym: "inhibition of nitrogen metabolic process" NARROW [] +synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "negative regulation of nitrogen metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051173 +name: positive regulation of nitrogen compound metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] +synonym: "activation of nitrogen metabolic process" NARROW [] +synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] +synonym: "positive regulation of nitrogen metabolism" EXACT [] +synonym: "stimulation of nitrogen metabolic process" NARROW [] +synonym: "up regulation of nitrogen metabolic process" EXACT [] +synonym: "up-regulation of nitrogen metabolic process" EXACT [] +synonym: "upregulation of nitrogen metabolic process" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0051174 +name: regulation of phosphorus metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] +synonym: "regulation of phosphorus metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006793 ! phosphorus metabolic process + +[Term] +id: GO:0051175 +name: negative regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] +synonym: "down regulation of sulfur metabolic process" EXACT [] +synonym: "down-regulation of sulfur metabolic process" EXACT [] +synonym: "downregulation of sulfur metabolic process" EXACT [] +synonym: "inhibition of sulfur metabolic process" NARROW [] +synonym: "negative regulation of sulfur metabolism" EXACT [] +synonym: "negative regulation of sulphur metabolic process" EXACT [] +synonym: "negative regulation of sulphur metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: negatively_regulates GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0051176 +name: positive regulation of sulfur metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai] +synonym: "activation of sulfur metabolic process" NARROW [] +synonym: "positive regulation of sulfur metabolism" EXACT [] +synonym: "positive regulation of sulphur metabolic process" EXACT [] +synonym: "positive regulation of sulphur metabolism" EXACT [] +synonym: "stimulation of sulfur metabolic process" NARROW [] +synonym: "up regulation of sulfur metabolic process" EXACT [] +synonym: "up-regulation of sulfur metabolic process" EXACT [] +synonym: "upregulation of sulfur metabolic process" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: positively_regulates GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0051177 +name: meiotic sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] +is_a: GO:0007062 ! sister chromatid cohesion +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0051178 +name: meiotic chromosome decondensation +namespace: biological_process +def: "The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai] +is_a: GO:0051312 ! chromosome decondensation +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051179 +name: localization +namespace: biological_process +alt_id: GO:1902578 +def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation." [GOC:ai, GOC:dos] +subset: goslim_pir +synonym: "establishment and maintenance of cellular component location" NARROW [] +synonym: "establishment and maintenance of localization" EXACT [] +synonym: "establishment and maintenance of position" EXACT [] +synonym: "establishment and maintenance of substance location" NARROW [] +synonym: "establishment and maintenance of substrate location" NARROW [] +synonym: "localisation" EXACT [GOC:mah] +synonym: "single organism localization" RELATED [GOC:TermGenie] +synonym: "single-organism localization" RELATED [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0051180 +name: vitamin transport +namespace: biological_process +def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] +subset: goslim_pir +synonym: "vitamin or cofactor transport" BROAD [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0051181 +name: obsolete cofactor transport +namespace: biological_process +def: "OBSOLETE. The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "vitamin or cofactor transport" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051182 +name: obsolete coenzyme transport +namespace: biological_process +def: "OBSOLETE. The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme. +is_obsolete: true + +[Term] +id: GO:0051184 +name: obsolete cofactor transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a cofactor from one side of a membrane to the other. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "cofactor transporter activity" RELATED [] +synonym: "vitamin or cofactor transporter activity" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051185 +name: obsolete coenzyme transmembrane transporter activity +namespace: molecular_function +def: "OBSOLETE. Enables the transfer of a coenzyme from one side of a membrane to the other. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group transport processes that are not all chemically related by the fact that they may be used as a coenzyme. +synonym: "coenzyme transporter activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0051186 +name: obsolete cofactor metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "cofactor metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051187 +name: obsolete cofactor catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "cofactor breakdown" EXACT [] +synonym: "cofactor catabolism" EXACT [] +synonym: "cofactor degradation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051188 +name: obsolete cofactor biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "cofactor anabolism" EXACT [] +synonym: "cofactor biosynthesis" EXACT [] +synonym: "cofactor formation" EXACT [] +synonym: "cofactor synthesis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051189 +name: prosthetic group metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +subset: goslim_pir +synonym: "coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "coenzyme and prosthetic group metabolism" BROAD [] +synonym: "prosthetic group metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process +relationship: part_of GO:0044267 ! cellular protein metabolic process + +[Term] +id: GO:0051190 +name: prosthetic group catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +synonym: "coenzyme and prosthetic group catabolic process" BROAD [] +synonym: "coenzyme and prosthetic group catabolism" BROAD [] +synonym: "prosthetic group breakdown" EXACT [] +synonym: "prosthetic group catabolism" EXACT [] +synonym: "prosthetic group degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0051189 ! prosthetic group metabolic process +relationship: part_of GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0051191 +name: prosthetic group biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai] +synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] +synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] +synonym: "prosthetic group anabolism" EXACT [] +synonym: "prosthetic group biosynthesis" EXACT [] +synonym: "prosthetic group formation" EXACT [] +synonym: "prosthetic group synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0051189 ! prosthetic group metabolic process +relationship: part_of GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0051192 +name: prosthetic group binding +namespace: molecular_function +def: "Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051193 +name: obsolete regulation of cofactor metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "regulation of cofactor metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051194 +name: obsolete positive regulation of cofactor metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "activation of cofactor metabolic process" NARROW [] +synonym: "positive regulation of cofactor metabolism" EXACT [] +synonym: "stimulation of cofactor metabolic process" NARROW [] +synonym: "up regulation of cofactor metabolic process" EXACT [] +synonym: "up-regulation of cofactor metabolic process" EXACT [] +synonym: "upregulation of cofactor metabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051195 +name: obsolete negative regulation of cofactor metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the cofactor role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all chemically related by the fact that they may be used as a cofactor. +synonym: "down regulation of cofactor metabolic process" EXACT [] +synonym: "down-regulation of cofactor metabolic process" EXACT [] +synonym: "downregulation of cofactor metabolic process" EXACT [] +synonym: "inhibition of cofactor metabolic process" NARROW [] +synonym: "negative regulation of cofactor metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051196 +name: obsolete regulation of coenzyme metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "regulation of coenzyme metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051197 +name: obsolete positive regulation of coenzyme metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "activation of coenzyme metabolic process" NARROW [] +synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "positive regulation of coenzyme metabolism" EXACT [] +synonym: "stimulation of coenzyme metabolic process" NARROW [] +synonym: "up regulation of coenzyme metabolic process" EXACT [] +synonym: "up-regulation of coenzyme metabolic process" EXACT [] +synonym: "upregulation of coenzyme metabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051198 +name: obsolete negative regulation of coenzyme metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai] +comment: 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. +synonym: "down regulation of coenzyme metabolic process" EXACT [] +synonym: "down-regulation of coenzyme metabolic process" EXACT [] +synonym: "downregulation of coenzyme metabolic process" EXACT [] +synonym: "inhibition of coenzyme metabolic process" NARROW [] +synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "negative regulation of coenzyme metabolism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051199 +name: regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +synonym: "regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "regulation of prosthetic group metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051200 +name: positive regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +synonym: "activation of prosthetic group metabolic process" NARROW [] +synonym: "positive regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "positive regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "positive regulation of prosthetic group metabolism" EXACT [] +synonym: "stimulation of prosthetic group metabolic process" NARROW [] +synonym: "up regulation of prosthetic group metabolic process" EXACT [] +synonym: "up-regulation of prosthetic group metabolic process" EXACT [] +synonym: "upregulation of prosthetic group metabolic process" EXACT [] +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0051199 ! regulation of prosthetic group metabolic process +relationship: positively_regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051201 +name: negative regulation of prosthetic group metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai] +synonym: "down regulation of prosthetic group metabolic process" EXACT [] +synonym: "down-regulation of prosthetic group metabolic process" EXACT [] +synonym: "downregulation of prosthetic group metabolic process" EXACT [] +synonym: "inhibition of prosthetic group metabolic process" NARROW [] +synonym: "negative regulation of coenzyme and prosthetic group metabolic process" BROAD [] +synonym: "negative regulation of coenzyme and prosthetic group metabolism" BROAD [] +synonym: "negative regulation of prosthetic group metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0051199 ! regulation of prosthetic group metabolic process +relationship: negatively_regulates GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0051202 +name: phytochromobilin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553] +synonym: "phytochromobilin metabolism" EXACT [] +is_a: GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:0051203 +name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde +namespace: biological_process +def: "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373] +comment: See also UniProtKB:P04160. +synonym: "peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde" EXACT [] +synonym: "peptidyl-aspartic acid reduction to form L-beta-formylalanine" EXACT [] +xref: RESID:AA0373 +is_a: GO:0018197 ! peptidyl-aspartic acid modification + +[Term] +id: GO:0051204 +name: protein insertion into mitochondrial membrane +namespace: biological_process +def: "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai] +synonym: "integral mitochondrial membrane protein localization" EXACT [] +synonym: "integral mitochondrial membrane protein positioning" EXACT [] +synonym: "localization of protein in mitochondrial membrane" EXACT [] +synonym: "positioning of protein in mitochondrial membrane" EXACT [] +synonym: "protein insertion into mitochondrion membrane" EXACT [] +synonym: "protein-mitochondrial membrane insertion" EXACT [] +synonym: "protein-mitochondrion membrane insertion" EXACT [] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0051205 ! protein insertion into membrane +is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane +relationship: part_of GO:0070585 ! protein localization to mitochondrion + +[Term] +id: GO:0051205 +name: protein insertion into membrane +namespace: biological_process +def: "The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai] +synonym: "integral membrane protein localization" EXACT [] +synonym: "integral membrane protein positioning" EXACT [] +synonym: "membrane protein localization" EXACT [] +synonym: "membrane protein positioning" EXACT [] +synonym: "protein-membrane insertion" EXACT [] +is_a: GO:0090150 ! establishment of protein localization to membrane +relationship: part_of GO:0034613 ! cellular protein localization +relationship: part_of GO:0061024 ! membrane organization + +[Term] +id: GO:0051206 +name: silicate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai] +synonym: "silicate metabolism" EXACT [] +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0051208 +name: sequestering of calcium ion +namespace: biological_process +def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "calcium ion (Ca2+) retention" EXACT [] +synonym: "calcium ion (Ca2+) sequestering" EXACT [] +synonym: "calcium ion (Ca2+) sequestration" EXACT [] +synonym: "calcium ion (Ca2+) storage" EXACT [] +synonym: "calcium ion storage activity" RELATED [] +synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] +synonym: "retention of calcium ion (Ca2+)" EXACT [] +synonym: "sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051209 +name: release of sequestered calcium ion into cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] +synonym: "calcium ion (Ca2+) mobilization" BROAD [] +synonym: "calcium mobilization" BROAD [] +synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+)" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0051283 ! negative regulation of sequestering of calcium ion +is_a: GO:0097553 ! calcium ion transmembrane import into cytosol + +[Term] +id: GO:0051210 +name: isotropic cell growth +namespace: biological_process +def: "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid] +synonym: "uniform cell growth" RELATED [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0051211 +name: anisotropic cell growth +namespace: biological_process +def: "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai] +synonym: "non-isotropic cell growth" EXACT [] +is_a: GO:0016049 ! cell growth + +[Term] +id: GO:0051212 +name: vanadium ion binding +namespace: molecular_function +def: "Binding to a vanadium ion (V)." [GOC:ai] +synonym: "V ion binding" EXACT [] +is_a: GO:0046914 ! transition metal ion binding + +[Term] +id: GO:0051213 +name: dioxygenase activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf] +subset: goslim_pir +xref: Reactome:R-HSA-112120 "Oxidative demethylation of 3-meC damaged DNA by ALKBH2" +xref: Reactome:R-HSA-112121 "Oxidative dealkylation of 1-etA damaged DNA By ALKBH2" +xref: Reactome:R-HSA-112124 "Oxidative demethylation of 3-meC damaged DNA By ALKBH3" +xref: Reactome:R-HSA-112125 "Oxidative dealkylation of 1-EtA damaged DNA by ABH3" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0051214 +name: RNAi-mediated antiviral immunity against RNA virus +namespace: biological_process +def: "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. In plants, DCL4 is the primary Dicer to detect RNA viruses." [PMID:15165191, PMID:17693253] +synonym: "RNA VIGS" EXACT [] +synonym: "RNA virus induced gene silencing" EXACT [] +synonym: "RNA virus-induced gene silencing" EXACT [] +is_a: GO:0009616 ! RNAi-mediated antiviral immune response + +[Term] +id: GO:0051215 +name: RNAi-mediated antiviral immunity against DNA virus +namespace: biological_process +def: "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. In plants, DCL3 is the primary Dicer to detect DNA viruses." [PMID:15165191, PMID:17693253, PMID:23151511] +synonym: "DNA VIGS" EXACT [] +synonym: "DNA virus induced gene silencing" EXACT [] +synonym: "DNA virus-induced gene silencing" EXACT [] +is_a: GO:0009616 ! RNAi-mediated antiviral immune response + +[Term] +id: GO:0051216 +name: cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:cjm, PMID:23251424] +synonym: "cartilage biogenesis" EXACT [] +synonym: "cartilage biosynthesis" EXACT [] +synonym: "cartilage element development" EXACT [] +synonym: "cartilage formation" EXACT [] +synonym: "cartilage organ development" EXACT [] +synonym: "chondrogenesis" EXACT [] +xref: Wikipedia:Chondrogenesis +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0001501 ! skeletal system development +relationship: part_of GO:0061448 ! connective tissue development + +[Term] +id: GO:0051217 +name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375] +xref: RESID:AA0375 +is_a: GO:0018197 ! peptidyl-aspartic acid modification +is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex + +[Term] +id: GO:0051218 +name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) +namespace: biological_process +def: "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376] +xref: RESID:AA02376 +is_a: GO:0042042 ! tungsten incorporation into tungsten-molybdopterin complex +is_a: GO:0050844 ! peptidyl-selenocysteine modification + +[Term] +id: GO:0051219 +name: phosphoprotein binding +namespace: molecular_function +def: "Binding to a phosphorylated protein." [GOC:ai] +subset: goslim_chembl +synonym: "phosphorylated protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051220 +name: cytoplasmic sequestering of protein +namespace: biological_process +def: "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai] +synonym: "cytoplasmic retention of protein" EXACT [] +synonym: "cytoplasmic sequestration of protein" EXACT [] +synonym: "cytoplasmic storage of protein" EXACT [] +synonym: "maintenance of protein location in cytoplasm" EXACT [GOC:dph, GOC:tb] +synonym: "retention of protein in cytoplasm" EXACT [] +synonym: "sequestering of protein in cytoplasm" EXACT [] +synonym: "sequestration of protein in cytoplasm" EXACT [] +synonym: "storage of protein in cytoplasm" EXACT [] +is_a: GO:0045185 ! maintenance of protein location + +[Term] +id: GO:0051221 +name: tungsten incorporation into metallo-sulfur cluster +namespace: biological_process +def: "The incorporation of tungsten into a metallo-sulfur cluster." [GOC:ai] +synonym: "tungsten incorporation into metallo-sulphur cluster" EXACT [] +is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster + +[Term] +id: GO:0051222 +name: positive regulation of protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of protein transport" NARROW [] +synonym: "stimulation of protein transport" NARROW [] +synonym: "up regulation of protein transport" EXACT [] +synonym: "up-regulation of protein transport" EXACT [] +synonym: "upregulation of protein transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:1904951 ! positive regulation of establishment of protein localization +relationship: positively_regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051223 +name: regulation of protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0070201 ! regulation of establishment of protein localization +relationship: regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051224 +name: negative regulation of protein transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of protein transport" EXACT [] +synonym: "down-regulation of protein transport" EXACT [] +synonym: "downregulation of protein transport" EXACT [] +synonym: "inhibition of protein transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:1904950 ! negative regulation of establishment of protein localization +relationship: negatively_regulates GO:0015031 ! protein transport + +[Term] +id: GO:0051225 +name: spindle assembly +namespace: biological_process +alt_id: GO:0051226 +alt_id: GO:0051227 +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] +synonym: "bipolar spindle biosynthesis" EXACT [] +synonym: "bipolar spindle formation" EXACT [] +synonym: "spindle biosynthesis" EXACT [] +synonym: "spindle formation" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0051228 +name: mitotic spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] +synonym: "mitotic spindle breakdown" EXACT [] +synonym: "mitotic spindle catabolism" EXACT [] +synonym: "mitotic spindle degradation" EXACT [] +synonym: "spindle breakdown during mitosis" EXACT [] +synonym: "spindle degradation during mitosis" EXACT [] +synonym: "spindle disassembly during mitosis" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization +is_a: GO:0051230 ! spindle disassembly + +[Term] +id: GO:0051229 +name: meiotic spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle during a meiotic cell cycle." [GOC:ai] +synonym: "meiotic spindle breakdown" EXACT [] +synonym: "meiotic spindle catabolism" EXACT [] +synonym: "meiotic spindle degradation" EXACT [] +synonym: "spindle breakdown during meiosis" EXACT [] +synonym: "spindle degradation during meiosis" EXACT [] +synonym: "spindle disassembly during meiosis" EXACT [] +is_a: GO:0000212 ! meiotic spindle organization +is_a: GO:0051230 ! spindle disassembly + +[Term] +id: GO:0051230 +name: spindle disassembly +namespace: biological_process +def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai] +synonym: "spindle breakdown" EXACT [] +synonym: "spindle catabolism" EXACT [] +synonym: "spindle degradation" EXACT [] +is_a: GO:0007051 ! spindle organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0051231 +name: spindle elongation +namespace: biological_process +def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007051 ! spindle organization +relationship: part_of GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0051232 +name: meiotic spindle elongation +namespace: biological_process +def: "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai] +synonym: "spindle elongation during meiosis" EXACT [] +is_a: GO:0051231 ! spindle elongation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0000212 ! meiotic spindle organization +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051233 +name: spindle midzone +namespace: cellular_component +def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] +synonym: "central spindle" EXACT [PMID:14528012] +synonym: "spindle equator" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0051234 +name: establishment of localization +namespace: biological_process +def: "Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos] +subset: goslim_agr +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +synonym: "establishment of localisation" EXACT [GOC:mah] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051235 +name: maintenance of location +namespace: biological_process +def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of localization" EXACT [] +synonym: "retention" NARROW [] +synonym: "sequestering" NARROW [] +synonym: "storage" NARROW [] +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051236 +name: establishment of RNA localization +namespace: biological_process +def: "The directed movement of RNA to a specific location." [GOC:ai] +synonym: "establishment of RNA localisation" EXACT [GOC:mah] +synonym: "RNA positioning" EXACT [] +synonym: "RNA recruitment" EXACT [] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0006403 ! RNA localization + +[Term] +id: GO:0051237 +name: maintenance of RNA location +namespace: biological_process +def: "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai] +synonym: "maintenance of RNA localization" RELATED [GOC:dph, GOC:tb] +synonym: "RNA retention" EXACT [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0006403 ! RNA localization + +[Term] +id: GO:0051238 +name: sequestering of metal ion +namespace: biological_process +def: "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "metal ion retention" EXACT [] +synonym: "metal ion sequestering" EXACT [] +synonym: "metal ion sequestration" EXACT [] +synonym: "metal ion storage" EXACT [] +synonym: "retention of metal ion" EXACT [] +synonym: "sequestration of metal ion" EXACT [] +synonym: "storage of metal ion" EXACT [] +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0051239 +name: regulation of multicellular organismal process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051240 +name: positive regulation of multicellular organismal process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] +synonym: "activation of multicellular organismal process" NARROW [] +synonym: "stimulation of multicellular organismal process" NARROW [] +synonym: "up regulation of multicellular organismal process" EXACT [] +synonym: "up-regulation of multicellular organismal process" EXACT [] +synonym: "upregulation of multicellular organismal process" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: positively_regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051241 +name: negative regulation of multicellular organismal process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai] +synonym: "down regulation of multicellular organismal process" EXACT [] +synonym: "down-regulation of multicellular organismal process" EXACT [] +synonym: "downregulation of multicellular organismal process" EXACT [] +synonym: "inhibition of multicellular organismal process" NARROW [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: negatively_regulates GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0051245 +name: negative regulation of cellular defense response +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of the cellular defense response." [GOC:ai] +synonym: "down regulation of cellular defense response" EXACT [] +synonym: "down-regulation of cellular defense response" EXACT [] +synonym: "downregulation of cellular defense response" EXACT [] +synonym: "inhibition of cellular defense response" NARROW [] +synonym: "negative regulation of cellular defence response" EXACT [] +is_a: GO:0010185 ! regulation of cellular defense response +is_a: GO:0031348 ! negative regulation of defense response +relationship: negatively_regulates GO:0006968 ! cellular defense response + +[Term] +id: GO:0051246 +name: regulation of protein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] +synonym: "regulation of protein metabolism" EXACT [] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051247 +name: positive regulation of protein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] +synonym: "activation of protein metabolic process" NARROW [] +synonym: "positive regulation of protein metabolism" EXACT [] +synonym: "stimulation of protein metabolic process" NARROW [] +synonym: "up regulation of protein metabolic process" EXACT [] +synonym: "up-regulation of protein metabolic process" EXACT [] +synonym: "upregulation of protein metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: positively_regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051248 +name: negative regulation of protein metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] +synonym: "down regulation of protein metabolic process" EXACT [] +synonym: "down-regulation of protein metabolic process" EXACT [] +synonym: "downregulation of protein metabolic process" EXACT [] +synonym: "inhibition of protein metabolic process" NARROW [] +synonym: "negative regulation of protein metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: negatively_regulates GO:0019538 ! protein metabolic process + +[Term] +id: GO:0051249 +name: regulation of lymphocyte activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte activation." [GOC:ai] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051250 +name: negative regulation of lymphocyte activation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai] +synonym: "down regulation of lymphocyte activation" EXACT [] +synonym: "down-regulation of lymphocyte activation" EXACT [] +synonym: "downregulation of lymphocyte activation" EXACT [] +synonym: "inhibition of lymphocyte activation" NARROW [] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: negatively_regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051251 +name: positive regulation of lymphocyte activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai] +synonym: "activation of lymphocyte activation" NARROW [] +synonym: "stimulation of lymphocyte activation" NARROW [] +synonym: "up regulation of lymphocyte activation" EXACT [] +synonym: "up-regulation of lymphocyte activation" EXACT [] +synonym: "upregulation of lymphocyte activation" EXACT [] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: positively_regulates GO:0046649 ! lymphocyte activation + +[Term] +id: GO:0051252 +name: regulation of RNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +synonym: "regulation of RNA metabolism" EXACT [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051253 +name: negative regulation of RNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +synonym: "down regulation of RNA metabolic process" EXACT [] +synonym: "down-regulation of RNA metabolic process" EXACT [] +synonym: "downregulation of RNA metabolic process" EXACT [] +synonym: "inhibition of RNA metabolic process" NARROW [] +synonym: "negative regulation of RNA metabolism" EXACT [] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: negatively_regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051254 +name: positive regulation of RNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] +synonym: "activation of RNA metabolic process" NARROW [] +synonym: "positive regulation of RNA metabolism" EXACT [] +synonym: "stimulation of RNA metabolic process" NARROW [] +synonym: "up regulation of RNA metabolic process" EXACT [] +synonym: "up-regulation of RNA metabolic process" EXACT [] +synonym: "upregulation of RNA metabolic process" EXACT [] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: positively_regulates GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0051255 +name: spindle midzone assembly +namespace: biological_process +def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] +synonym: "spindle midzone biogenesis" EXACT [] +synonym: "spindle midzone biosynthesis" EXACT [] +synonym: "spindle midzone formation" EXACT [] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0022402 ! cell cycle process +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0051225 ! spindle assembly + +[Term] +id: GO:0051256 +name: mitotic spindle midzone assembly +namespace: biological_process +def: "The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw, PMID:24239120] +synonym: "mitotic spindle midzone biogenesis" EXACT [] +synonym: "mitotic spindle midzone biosynthesis" EXACT [] +synonym: "mitotic spindle midzone formation" EXACT [] +synonym: "spindle midzone assembly involved in mitosis" EXACT [] +synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] +synonym: "spindle midzone formation involved in mitosis" EXACT [] +is_a: GO:0051255 ! spindle midzone assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000022 ! mitotic spindle elongation +relationship: part_of GO:0090307 ! mitotic spindle assembly + +[Term] +id: GO:0051257 +name: meiotic spindle midzone assembly +namespace: biological_process +def: "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb] +synonym: "meiotic spindle midzone biogenesis" EXACT [] +synonym: "meiotic spindle midzone biosynthesis" EXACT [] +synonym: "meiotic spindle midzone formation" EXACT [] +synonym: "spindle midzone assembly involved in meiosis" EXACT [] +synonym: "spindle midzone biogenesis involved in meiosis" EXACT [] +synonym: "spindle midzone biosynthesis involved in meiosis" EXACT [] +synonym: "spindle midzone formation involved in meiosis" EXACT [] +is_a: GO:0051255 ! spindle midzone assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0051258 +name: protein polymerization +namespace: biological_process +def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] +subset: goslim_pir +synonym: "protein polymer biosynthesis" EXACT [] +synonym: "protein polymer biosynthetic process" EXACT [] +synonym: "protein polymer formation" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0051259 +name: protein complex oligomerization +namespace: biological_process +alt_id: GO:0035786 +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai, PMID:18293929] +synonym: "protein multimerization" RELATED [GOC:bf] +synonym: "protein oligomer assembly" EXACT [] +synonym: "protein oligomer biosynthesis" BROAD [] +synonym: "protein oligomer biosynthetic process" BROAD [] +synonym: "protein oligomer formation" EXACT [] +synonym: "protein oligomerization" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0051260 +name: protein homooligomerization +namespace: biological_process +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] +synonym: "protein homooligomer assembly" EXACT [] +synonym: "protein homooligomer biosynthesis" EXACT [] +synonym: "protein homooligomer biosynthetic process" EXACT [] +synonym: "protein homooligomer formation" EXACT [] +synonym: "protein homooligomerization activity" RELATED [] +is_a: GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0051261 +name: protein depolymerization +namespace: biological_process +def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] +subset: goslim_pir +synonym: "protein polymer breakdown" EXACT [] +synonym: "protein polymer catabolic process" EXACT [] +synonym: "protein polymer catabolism" EXACT [] +synonym: "protein polymer degradation" EXACT [] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0051262 +name: protein tetramerization +namespace: biological_process +def: "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd] +synonym: "protein tetramer assembly" EXACT [] +synonym: "protein tetramer biosynthesis" EXACT [] +synonym: "protein tetramer biosynthetic process" EXACT [] +synonym: "protein tetramer formation" EXACT [] +is_a: GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0051263 +name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine +namespace: biological_process +def: "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374] +synonym: "microcin E492 anabolism by siderophore ester modification of peptidyl-serine" EXACT [] +synonym: "microcin E492 formation by siderophore ester modification of peptidyl-serine" EXACT [] +synonym: "microcin E492 synthesis by siderophore ester modification of peptidyl-serine" EXACT [] +xref: RESID:AA0374 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0018350 ! protein esterification + +[Term] +id: GO:0051264 +name: mono-olein transacylation activity +namespace: molecular_function +def: "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929] +synonym: "acyl-CoA-independent mono-olein transacylation" EXACT [] +synonym: "MOG transacylation" EXACT [] +synonym: "mono-oleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "mono-oleoylglycerol transacylase activity" EXACT [] +synonym: "monoolein transacylation" EXACT [] +synonym: "monooleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "monooleoylglycerol transacylase activity" EXACT [] +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0051265 +name: diolein transacylation activity +namespace: molecular_function +def: "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929] +synonym: "acyl-CoA-independent diolein transacylation" EXACT [] +synonym: "dioleoylglycerol O-acyltransferase activity" EXACT [] +synonym: "dioleoylglycerol transacylase activity" EXACT [] +synonym: "DOG transacylation" EXACT [] +is_a: GO:0016411 ! acylglycerol O-acyltransferase activity + +[Term] +id: GO:0051266 +name: sirohydrochlorin ferrochelatase activity +namespace: molecular_function +def: "Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin." [RHEA:24360] +synonym: "siroheme ferro-lyase (sirohydrochlorin-forming)" RELATED [] +synonym: "siroheme synthase activity" BROAD [] +synonym: "sirohydrochlorin ferro-lyase activity" EXACT [] +xref: EC:4.99.1.4 +xref: KEGG_REACTION:R02864 +xref: MetaCyc:SIROHEME-FERROCHELAT-RXN +xref: RHEA:24360 +is_a: GO:0004325 ! ferrochelatase activity + +[Term] +id: GO:0051267 +name: CP2 mannose-ethanolamine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134] +synonym: "addition of ethanolamine phosphate to mannose of GPI precursor CP2" EXACT [] +synonym: "CP2 ethanolamine phosphate transferase activity" EXACT [] +synonym: "CP2 EtN-P transferase activity" EXACT [] +synonym: "CP2 phosphoethanolamine transferase activity" EXACT [] +synonym: "gpi7 activity" RELATED [] +is_a: GO:0051377 ! mannose-ethanolamine phosphotransferase activity + +[Term] +id: GO:0051268 +name: alpha-keto amide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669] +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0051269 +name: alpha-keto ester reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669] +xref: EC:1.2.-.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0051270 +name: regulation of cellular component movement +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] +synonym: "regulation of cell movement" RELATED [] +synonym: "regulation of cellular component motion" EXACT [GOC:mah] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0006928 ! movement of cell or subcellular component + +[Term] +id: GO:0051271 +name: negative regulation of cellular component movement +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] +synonym: "negative regulation of cellular component motion" EXACT [GOC:mah] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051270 ! regulation of cellular component movement +relationship: negatively_regulates GO:0006928 ! movement of cell or subcellular component + +[Term] +id: GO:0051272 +name: positive regulation of cellular component movement +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl] +synonym: "positive regulation of cellular component motion" EXACT [GOC:mah] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051270 ! regulation of cellular component movement +relationship: positively_regulates GO:0006928 ! movement of cell or subcellular component + +[Term] +id: GO:0051273 +name: beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai] +synonym: "beta-glucan metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process + +[Term] +id: GO:0051274 +name: beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans." [GOC:ai] +synonym: "beta-glucan anabolism" EXACT [] +synonym: "beta-glucan biosynthesis" EXACT [] +synonym: "beta-glucan formation" EXACT [] +synonym: "beta-glucan synthesis" EXACT [] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0051275 +name: beta-glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-glucans." [GOC:ai] +synonym: "beta-glucan breakdown" EXACT [] +synonym: "beta-glucan catabolism" EXACT [] +synonym: "beta-glucan degradation" EXACT [] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0051273 ! beta-glucan metabolic process + +[Term] +id: GO:0051276 +name: chromosome organization +namespace: biological_process +alt_id: GO:0007001 +alt_id: GO:0051277 +def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_pir +synonym: "chromosome organisation" EXACT [] +synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] +synonym: "maintenance of genome integrity" RELATED [] +synonym: "nuclear genome maintenance" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0051278 +name: fungal-type cell wall polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu] +synonym: "cell wall polysaccharide anabolism" BROAD [] +synonym: "cell wall polysaccharide formation" BROAD [] +synonym: "cell wall polysaccharide synthesis" BROAD [] +synonym: "chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process" NARROW [] +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process +is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process +relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0051279 +name: regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] +synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] +synonym: "regulation of calcium mobilization" EXACT [] +synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0051282 ! regulation of sequestering of calcium ion +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051280 +name: negative regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "negative regulation of calcium mobilization" BROAD [] +synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:0051284 ! positive regulation of sequestering of calcium ion +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051281 +name: positive regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "positive regulation of calcium mobilization" BROAD [] +synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] +is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051282 +name: regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051283 +name: negative regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "down regulation of sequestering of calcium ion" EXACT [] +synonym: "down-regulation of sequestering of calcium ion" EXACT [] +synonym: "downregulation of sequestering of calcium ion" EXACT [] +synonym: "inhibition of sequestering of calcium ion" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051284 +name: positive regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "activation of sequestering of calcium ion" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] +synonym: "stimulation of sequestering of calcium ion" NARROW [] +synonym: "up regulation of sequestering of calcium ion" EXACT [] +synonym: "up-regulation of sequestering of calcium ion" EXACT [] +synonym: "upregulation of sequestering of calcium ion" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +relationship: positively_regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051285 +name: cell cortex of cell tip +namespace: cellular_component +def: "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai] +synonym: "cell cortex of cell end" EXACT [] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0051286 ! cell tip + +[Term] +id: GO:0051286 +name: cell tip +namespace: cellular_component +def: "The region at the end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah] +comment: Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to the thin ends of elongated cells, such as the ends of axons or dendrites. +synonym: "cell end" EXACT [GOC:mah] +is_a: GO:0060187 ! cell pole + +[Term] +id: GO:0051287 +name: NAD binding +namespace: molecular_function +alt_id: GO:0051288 +def: "Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] +subset: goslim_chembl +synonym: "NAD or NADH binding" RELATED [GOC:mah] +synonym: "NAD+ or NADH binding" RELATED [] +synonym: "nicotinamide adenine dinucleotide binding" EXACT [] +is_a: GO:0000166 ! nucleotide binding + +[Term] +id: GO:0051289 +name: protein homotetramerization +namespace: biological_process +def: "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators] +synonym: "protein homotetramer assembly" EXACT [] +synonym: "protein homotetramer biosynthesis" EXACT [] +synonym: "protein homotetramer biosynthetic process" EXACT [] +synonym: "protein homotetramer formation" EXACT [] +is_a: GO:0051260 ! protein homooligomerization +is_a: GO:0051262 ! protein tetramerization + +[Term] +id: GO:0051290 +name: protein heterotetramerization +namespace: biological_process +def: "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators] +synonym: "protein heterotetramer assembly" EXACT [] +synonym: "protein heterotetramer biosynthesis" EXACT [] +synonym: "protein heterotetramer biosynthetic process" EXACT [] +synonym: "protein heterotetramer formation" EXACT [] +is_a: GO:0051262 ! protein tetramerization +is_a: GO:0051291 ! protein heterooligomerization + +[Term] +id: GO:0051291 +name: protein heterooligomerization +namespace: biological_process +def: "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai] +synonym: "protein heterooligomer assembly" EXACT [] +synonym: "protein heterooligomer biosynthesis" EXACT [] +synonym: "protein heterooligomer biosynthetic process" EXACT [] +synonym: "protein heterooligomer formation" EXACT [] +is_a: GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0051292 +name: nuclear pore complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah] +synonym: "NPC assembly" EXACT [] +synonym: "nuclear pore assembly" EXACT [] +synonym: "nuclear pore biogenesis" EXACT [] +synonym: "nuclear pore biosynthesis" EXACT [] +synonym: "nuclear pore complex biogenesis" EXACT [] +synonym: "nuclear pore complex biosynthesis" EXACT [] +synonym: "nuclear pore complex formation" EXACT [] +synonym: "nuclear pore formation" EXACT [] +is_a: GO:0006999 ! nuclear pore organization +is_a: GO:0046931 ! pore complex assembly + +[Term] +id: GO:0051293 +name: establishment of spindle localization +namespace: biological_process +def: "The directed movement of the spindle to a specific location in the cell." [GOC:ai] +synonym: "establishment of spindle localisation" EXACT [GOC:mah] +synonym: "spindle positioning" EXACT [] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051653 ! spindle localization +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051294 +name: establishment of spindle orientation +namespace: biological_process +def: "Any process that set the alignment of spindle relative to other cellular structures." [GOC:ai] +synonym: "orienting of spindle" EXACT [] +synonym: "spindle orientation" EXACT [] +is_a: GO:0051293 ! establishment of spindle localization +relationship: part_of GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:0051295 +name: establishment of meiotic spindle localization +namespace: biological_process +def: "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai] +synonym: "establishment of meiotic spindle localisation" EXACT [GOC:mah] +synonym: "meiotic spindle positioning" EXACT [] +synonym: "spindle positioning during meiosis" RELATED [] +synonym: "spindle positioning involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051293 ! establishment of spindle localization +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0051296 +name: establishment of meiotic spindle orientation +namespace: biological_process +def: "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai] +synonym: "establishment of spindle orientation during meiosis" RELATED [] +synonym: "establishment of spindle orientation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "meiotic spindle orientation" EXACT [] +synonym: "orienting of meiotic spindle" EXACT [] +is_a: GO:0051294 ! establishment of spindle orientation +is_a: GO:0051295 ! establishment of meiotic spindle localization + +[Term] +id: GO:0051298 +name: centrosome duplication +namespace: biological_process +def: "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai] +synonym: "centrosome replication" EXACT [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007098 ! centrosome cycle + +[Term] +id: GO:0051299 +name: centrosome separation +namespace: biological_process +def: "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007098 ! centrosome cycle + +[Term] +id: GO:0051300 +name: spindle pole body organization +namespace: biological_process +alt_id: GO:0051426 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "SPB maturation" RELATED [GOC:vw] +synonym: "SPB organization" EXACT [] +synonym: "spindle pole body maturation" RELATED [GOC:vw] +synonym: "spindle pole body organisation" EXACT [] +synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:0051301 +name: cell division +namespace: biological_process +def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] +comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_pir +xref: Wikipedia:Cell_division +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0051302 +name: regulation of cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051301 ! cell division + +[Term] +id: GO:0051303 +name: establishment of chromosome localization +namespace: biological_process +def: "The directed movement of a chromosome to a specific location." [GOC:ai] +synonym: "chromosome positioning" EXACT [] +synonym: "establishment of chromosome localisation" EXACT [GOC:mah] +is_a: GO:0050000 ! chromosome localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051304 +name: chromosome separation +namespace: biological_process +alt_id: GO:0034500 +def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243] +synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243] +synonym: "rDNA separation" NARROW [] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051305 +name: chromosome movement towards spindle pole +namespace: biological_process +def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai] +synonym: "chromosome migration to spindle pole" EXACT [] +synonym: "chromosome movement" BROAD [] +synonym: "chromosome movement to spindle pole" EXACT [] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051303 ! establishment of chromosome localization +relationship: part_of GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0051306 +name: mitotic sister chromatid separation +namespace: biological_process +def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] +synonym: "chromosome separation during mitosis" RELATED [] +synonym: "mitotic chromosome separation" RELATED [] +synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah] +synonym: "sister chromatid separation during mitosis" EXACT [] +is_a: GO:0051304 ! chromosome separation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0051307 +name: meiotic chromosome separation +namespace: biological_process +def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai] +synonym: "chromosome separation during meiosis" EXACT [] +synonym: "meiotic chromosome resolution" EXACT [GOC:mah] +is_a: GO:0051304 ! chromosome separation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051308 +name: male meiosis chromosome separation +namespace: biological_process +def: "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai] +synonym: "chromosome separation during male meiosis" EXACT [] +synonym: "male meiosis chromosome resolution" EXACT [GOC:mah] +is_a: GO:0007060 ! male meiosis chromosome segregation +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051309 +name: female meiosis chromosome separation +namespace: biological_process +def: "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai] +synonym: "chromosome separation during female meiosis" EXACT [] +synonym: "female meiosis chromosome resolution" EXACT [GOC:mah] +is_a: GO:0016321 ! female meiosis chromosome segregation +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051310 +name: metaphase plate congression +namespace: biological_process +def: "The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle." [GOC:ai] +synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051303 ! establishment of chromosome localization +relationship: part_of GO:0098813 ! nuclear chromosome segregation + +[Term] +id: GO:0051311 +name: meiotic metaphase plate congression +namespace: biological_process +def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] +synonym: "metaphase plate congression during meiosis" EXACT [] +is_a: GO:0051310 ! metaphase plate congression +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051312 +name: chromosome decondensation +namespace: biological_process +def: "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0051315 +name: attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +alt_id: GO:0051314 +def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896] +comment: This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation) +synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] +synonym: "attachment of spindle microtubules to mitotic chromosome" EXACT [] +synonym: "mitotic bipolar attachment" RELATED [GOC:vw] +is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007080 ! mitotic metaphase plate congression + +[Term] +id: GO:0051316 +name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation +namespace: biological_process +alt_id: GO:0051317 +def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] +synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to meiotic chromosome" EXACT [] +is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045132 ! meiotic chromosome segregation + +[Term] +id: GO:0051318 +name: G1 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:G1_phase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051319 +name: G2 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:G2_phase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051320 +name: S phase +namespace: biological_process +def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "S-phase" EXACT [] +xref: Wikipedia:S_phase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0051325 ! interphase + +[Term] +id: GO:0051321 +name: meiotic cell cycle +namespace: biological_process +alt_id: GO:0007126 +def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] +comment: Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. +subset: goslim_drosophila +subset: goslim_yeast +synonym: "meiosis" RELATED [] +xref: Wikipedia:Meiosis +is_a: GO:0007049 ! cell cycle +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0051322 +name: anaphase +namespace: biological_process +def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Anaphase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051323 +name: metaphase +namespace: biological_process +def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Metaphase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051324 +name: prophase +namespace: biological_process +def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Prophase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051325 +name: interphase +namespace: biological_process +def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "karyostasis" EXACT [] +synonym: "resting phase" BROAD [] +xref: Wikipedia:Interphase +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0051326 +name: telophase +namespace: biological_process +def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] +comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +xref: Wikipedia:Telophase +is_a: GO:0022403 ! cell cycle phase +relationship: part_of GO:0000279 ! M phase + +[Term] +id: GO:0051327 +name: meiotic M phase +namespace: biological_process +def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "M phase of meiotic cell cycle" EXACT [] +is_a: GO:0000279 ! M phase +is_a: GO:0098762 ! meiotic cell cycle phase + +[Term] +id: GO:0051328 +name: meiotic interphase +namespace: biological_process +def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "interphase of meiotic cell cycle" EXACT [] +is_a: GO:0051325 ! interphase +is_a: GO:0098762 ! meiotic cell cycle phase + +[Term] +id: GO:0051329 +name: mitotic interphase +namespace: biological_process +def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "interphase of mitotic cell cycle" EXACT [] +is_a: GO:0051325 ! interphase +is_a: GO:0098763 ! mitotic cell cycle phase + +[Term] +id: GO:0051330 +name: meiotic G1 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "G1 phase of meiotic cell cycle" EXACT [] +is_a: GO:0051318 ! G1 phase +relationship: part_of GO:0051328 ! meiotic interphase + +[Term] +id: GO:0051331 +name: meiotic G2 phase +namespace: biological_process +def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "G2 phase of meiotic cell cycle" EXACT [] +is_a: GO:0051319 ! G2 phase +relationship: part_of GO:0051328 ! meiotic interphase + +[Term] +id: GO:0051332 +name: meiotic S phase +namespace: biological_process +def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "premeiotic S-phase" EXACT [] +synonym: "S phase of meiotic cell cycle" EXACT [] +synonym: "S-phase of meiotic cell cycle" EXACT [] +is_a: GO:0051320 ! S phase +relationship: part_of GO:0051328 ! meiotic interphase + +[Term] +id: GO:0051333 +name: meiotic nuclear membrane reassembly +namespace: biological_process +def: "The cell cycle process in which the reformation of the nuclear membranes during meiosis occurs." [GOC:ai] +synonym: "meiotic nuclear envelope reassembly" RELATED [] +is_a: GO:0031468 ! nuclear membrane reassembly +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0051334 +name: meiosis I nuclear membrane reassembly +namespace: biological_process +def: "The reformation of the nuclear membranes during meiosis I." [GOC:ai] +synonym: "meiosis I nuclear envelope reassembly" RELATED [] +is_a: GO:0051333 ! meiotic nuclear membrane reassembly +relationship: part_of GO:0007127 ! meiosis I + +[Term] +id: GO:0051335 +name: meiosis II nuclear membrane reassembly +namespace: biological_process +def: "The reformation of the nuclear membrane during meiosis II." [GOC:ai] +synonym: "meiosis II nuclear envelope reassembly" RELATED [] +is_a: GO:0051333 ! meiotic nuclear membrane reassembly +relationship: part_of GO:0007135 ! meiosis II + +[Term] +id: GO:0051336 +name: regulation of hydrolase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [GOC:ai] +synonym: "hydrolase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051337 +name: amitosis +namespace: biological_process +def: "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544] +synonym: "direct nuclear division" EXACT [] +synonym: "Remak nuclear division" EXACT [] +is_a: GO:0000280 ! nuclear division + +[Term] +id: GO:0051338 +name: regulation of transferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [GOC:ai] +comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. +subset: gocheck_do_not_manually_annotate +synonym: "transferase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051339 +name: regulation of lyase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [GOC:ai] +synonym: "lyase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051340 +name: regulation of ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [GOC:ai] +synonym: "ligase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051341 +name: regulation of oxidoreductase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:ai] +synonym: "oxidoreductase regulator" EXACT [] +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:0051342 +name: regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase regulator" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase regulator" NARROW [] +synonym: "cAMP phosphodiesterase regulator" NARROW [] +synonym: "phosphodiesterase regulator" RELATED [] +synonym: "regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] +synonym: "regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051343 +name: positive regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase activator" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase activator" NARROW [] +synonym: "activation of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "cAMP phosphodiesterase activator" NARROW [] +synonym: "phosphodiesterase activator" RELATED [] +synonym: "positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "positive regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "positive regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] +synonym: "positive regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +synonym: "stimulation of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "up regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "up-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "upregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:0051344 +name: negative regulation of cyclic-nucleotide phosphodiesterase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb] +synonym: "3',5' cyclic nucleotide phosphodiesterase inhibitor" EXACT [] +synonym: "3',5'-cyclic-AMP phosphodiesterase inhibitor" NARROW [] +synonym: "cAMP phosphodiesterase inhibitor" NARROW [] +synonym: "down regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "down-regulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "downregulation of cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "inhibition of cyclic nucleotide phosphodiesterase activity" NARROW [] +synonym: "negative regulation of 3',5' cyclic nucleotide phosphodiesterase activity" EXACT [] +synonym: "negative regulation of 3',5'-cyclic-AMP phosphodiesterase activity" NARROW [] +synonym: "negative regulation of cAMP phosphodiesterase activity" NARROW [] +synonym: "negative regulation of cGMP phosphodiesterase activity" NARROW [GOC:tb] +synonym: "negative regulation of cyclic nucleotide phosphodiesterase activity" EXACT [GOC:tb] +synonym: "phosphodiesterase inhibitor" RELATED [] +is_a: GO:0051342 ! regulation of cyclic-nucleotide phosphodiesterase activity +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:0051345 +name: positive regulation of hydrolase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] +synonym: "activation of hydrolase activity" NARROW [] +synonym: "hydrolase activator" EXACT [] +synonym: "stimulation of hydrolase activity" NARROW [] +synonym: "up regulation of hydrolase activity" EXACT [] +synonym: "up-regulation of hydrolase activity" EXACT [] +synonym: "upregulation of hydrolase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051346 +name: negative regulation of hydrolase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] +synonym: "down regulation of hydrolase activity" EXACT [] +synonym: "down-regulation of hydrolase activity" EXACT [] +synonym: "downregulation of hydrolase activity" EXACT [] +synonym: "hydrolase inhibitor" EXACT [] +synonym: "inhibition of hydrolase activity" NARROW [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051347 +name: positive regulation of transferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] +comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. +subset: gocheck_do_not_manually_annotate +synonym: "activation of transferase activity" NARROW [] +synonym: "stimulation of transferase activity" NARROW [] +synonym: "transferase activator" EXACT [] +synonym: "up regulation of transferase activity" EXACT [] +synonym: "up-regulation of transferase activity" EXACT [] +synonym: "upregulation of transferase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051348 +name: negative regulation of transferase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] +comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. +subset: gocheck_do_not_manually_annotate +synonym: "down regulation of transferase activity" EXACT [] +synonym: "down-regulation of transferase activity" EXACT [] +synonym: "downregulation of transferase activity" EXACT [] +synonym: "inhibition of transferase activity" NARROW [] +synonym: "transferase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051349 +name: positive regulation of lyase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] +synonym: "activation of lyase activity" NARROW [] +synonym: "lyase activator" EXACT [] +synonym: "stimulation of lyase activity" NARROW [] +synonym: "up regulation of lyase activity" EXACT [] +synonym: "up-regulation of lyase activity" EXACT [] +synonym: "upregulation of lyase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0051350 +name: negative regulation of lyase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai] +synonym: "down regulation of lyase activity" EXACT [] +synonym: "down-regulation of lyase activity" EXACT [] +synonym: "downregulation of lyase activity" EXACT [] +synonym: "inhibition of lyase activity" NARROW [] +synonym: "lyase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:0051351 +name: positive regulation of ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] +synonym: "activation of ligase activity" NARROW [] +synonym: "ligase activator" EXACT [] +synonym: "stimulation of ligase activity" NARROW [] +synonym: "up regulation of ligase activity" EXACT [] +synonym: "up-regulation of ligase activity" EXACT [] +synonym: "upregulation of ligase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0051352 +name: negative regulation of ligase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] +synonym: "down regulation of ligase activity" EXACT [] +synonym: "down-regulation of ligase activity" EXACT [] +synonym: "downregulation of ligase activity" EXACT [] +synonym: "inhibition of ligase activity" NARROW [] +synonym: "ligase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:0051353 +name: positive regulation of oxidoreductase activity +namespace: biological_process +alt_id: GO:0009391 +def: "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] +synonym: "activation of oxidoreductase activity" NARROW [] +synonym: "oxidoreductase activator" EXACT [] +synonym: "ribonucleotide reductase activating enzyme activity" NARROW [] +synonym: "stimulation of oxidoreductase activity" NARROW [] +synonym: "up regulation of oxidoreductase activity" EXACT [] +synonym: "up-regulation of oxidoreductase activity" EXACT [] +synonym: "upregulation of oxidoreductase activity" EXACT [] +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0051354 +name: negative regulation of oxidoreductase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai] +synonym: "down regulation of oxidoreductase activity" EXACT [] +synonym: "down-regulation of oxidoreductase activity" EXACT [] +synonym: "downregulation of oxidoreductase activity" EXACT [] +synonym: "inhibition of oxidoreductase activity" NARROW [] +synonym: "oxidoreductase inhibitor" EXACT [] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0051355 +name: proprioception involved in equilibrioception +namespace: biological_process +def: "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] +synonym: "equilibrioception by proprioception" EXACT [] +synonym: "perception of orientation with respect to gravity by proprioception" EXACT [] +synonym: "proprioception during equilibrioception" RELATED [GOC:dph, GOC:tb] +is_a: GO:0019230 ! proprioception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0051356 +name: visual perception involved in equilibrioception +namespace: biological_process +def: "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai] +synonym: "equilibrioception by visual perception" NARROW [] +synonym: "perception of orientation with respect to gravity by visual perception" EXACT [] +synonym: "visual perception during equilibrioception" RELATED [GOC:dph, GOC:tb] +is_a: GO:0007601 ! visual perception +relationship: part_of GO:0050957 ! equilibrioception + +[Term] +id: GO:0051357 +name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one +namespace: biological_process +def: "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377] +comment: Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'. +synonym: "biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT [] +xref: RESID:AA0377 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018212 ! peptidyl-tyrosine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051358 +name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0378 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018200 ! peptidyl-glutamic acid modification +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051359 +name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0379 +is_a: GO:0018149 ! peptide cross-linking +is_a: GO:0018201 ! peptidyl-glycine modification +is_a: GO:0018206 ! peptidyl-methionine modification +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051360 +name: peptide cross-linking via L-asparagine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0380 +is_a: GO:0018196 ! peptidyl-asparagine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051361 +name: peptide cross-linking via L-lysine 5-imidazolinone glycine +namespace: biological_process +def: "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine" EXACT [] +xref: RESID:AA0381 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051362 +name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine +namespace: biological_process +def: "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382] +comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. +synonym: "biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] +synonym: "biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT [] +xref: RESID:AA0382 +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine +is_a: GO:0018298 ! protein-chromophore linkage + +[Term] +id: GO:0051363 +name: peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein +namespace: biological_process +def: "The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [PMID:8163519, PMID:9086265, RESID:AA0383] +comment: Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. +xref: RESID:AA0383 +is_a: GO:0018104 ! peptidoglycan-protein cross-linking +is_a: GO:0018194 ! peptidyl-alanine modification + +[Term] +id: GO:0051364 +name: N-terminal peptidyl-proline N-formylation +namespace: biological_process +def: "The formylation of the N-terminal proline of proteins to form the derivative N-formylproline." [PMID:12051774, PMID:5464655, RESID:AA0384] +xref: RESID:AA0384 +is_a: GO:0018004 ! N-terminal protein formylation +is_a: GO:0018208 ! peptidyl-proline modification + +[Term] +id: GO:0051365 +name: cellular response to potassium ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions." [GOC:sm] +synonym: "cellular response to K+ ion deprivation" EXACT [] +synonym: "cellular response to K+ ion starvation" EXACT [] +synonym: "cellular response to potassium ion deprivation" EXACT [] +synonym: "cellular response to potassium starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0051366 +name: protein decanoylation +namespace: biological_process +def: "The modification of a protein amino acid by formation of an ester or amide with decanoic acid." [GOC:jsg] +synonym: "protein amino acid decanoylation" EXACT [GOC:bf] +is_a: GO:0006497 ! protein lipidation +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0051367 +name: peptidyl-serine decanoylation +namespace: biological_process +def: "The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin." [GOC:jsg, PMID:12630926, RESID:AA0385] +xref: RESID:AA0385 +is_a: GO:0018209 ! peptidyl-serine modification +is_a: GO:0051366 ! protein decanoylation + +[Term] +id: GO:0051368 +name: peptidyl-threonine octanoylation +namespace: biological_process +def: "The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] +xref: RESID:AA0386 +is_a: GO:0018190 ! protein octanoylation +is_a: GO:0018210 ! peptidyl-threonine modification + +[Term] +id: GO:0051369 +name: peptidyl-threonine decanoylation +namespace: biological_process +def: "The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin." [GOC:jsg, PMID:11546772, RESID:AA0387] +xref: RESID:AA0387 +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0051366 ! protein decanoylation + +[Term] +id: GO:0051370 +name: obsolete ZASP binding +namespace: molecular_function +def: "OBSOLETE. Binding to Z-band alternatively spliced PDZ motif protein (ZASP). ZASP is a Z-band protein specifically expressed in heart and skeletal muscle. This protein contains N-terminal PDZ domain and C-terminal LIM domain." [PMID:10427098, PMID:11699871] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "Z-band alternatively spliced PDZ-motif protein binding" EXACT [] +synonym: "ZASP binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0051371 +name: muscle alpha-actinin binding +namespace: molecular_function +def: "Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc." [PMID:10984498, PMID:11699871, PMID:15014165] +synonym: "alpha-actinin 2 binding" NARROW [] +synonym: "alpha-actinin 3 binding" NARROW [] +is_a: GO:0051393 ! alpha-actinin binding + +[Term] +id: GO:0051373 +name: FATZ binding +namespace: molecular_function +alt_id: GO:0051374 +alt_id: GO:0051375 +alt_id: GO:0051376 +def: "Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components." [PMID:10984498, PMID:11699871] +synonym: "calsarcin 1 binding" EXACT [] +synonym: "calsarcin 2 binding" EXACT [] +synonym: "calsarcin 3 binding" EXACT [] +synonym: "calsarcin binding" EXACT [] +synonym: "FATZ 1 binding" EXACT [] +synonym: "FATZ 2 binding" EXACT [] +synonym: "FATZ 3 binding" EXACT [] +synonym: "filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle" EXACT [] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:0051377 +name: mannose-ethanolamine phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor." [PMID:15632136] +synonym: "addition of ethanolamine phosphate to mannose of GPI precursor" EXACT [] +synonym: "ethanolamine phosphate transferase activity" BROAD [] +synonym: "EtN-P transferase activity" EXACT [] +synonym: "phosphoethanolamine transferase activity" BROAD [] +xref: Reactome:R-HSA-162798 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol" +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0051378 +name: serotonin binding +namespace: molecular_function +def: "Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:ai] +synonym: "5-hydroxytryptamine binding" EXACT [] +is_a: GO:0043169 ! cation binding +is_a: GO:0043176 ! amine binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0051379 +name: epinephrine binding +namespace: molecular_function +def: "Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] +synonym: "adrenaline binding" EXACT [] +is_a: GO:1901338 ! catecholamine binding + +[Term] +id: GO:0051380 +name: norepinephrine binding +namespace: molecular_function +def: "Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] +synonym: "noradrenaline binding" EXACT [] +is_a: GO:1901338 ! catecholamine binding + +[Term] +id: GO:0051381 +name: histamine binding +namespace: molecular_function +def: "Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0043169 ! cation binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0051382 +name: kinetochore assembly +namespace: biological_process +alt_id: GO:0000069 +def: "The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai] +synonym: "centromere and kinetochore complex maturation" NARROW [] +synonym: "centromere/kinetochore complex maturation" NARROW [] +synonym: "chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "kinetochore formation" RELATED [] +is_a: GO:0051383 ! kinetochore organization +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140694 ! non-membrane-bounded organelle assembly +relationship: part_of GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0051383 +name: kinetochore organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] +synonym: "kinetochore organisation" EXACT [] +synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0051384 +name: response to glucocorticoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai, PMID:9884123] +synonym: "response to glucocorticoid stimulus" EXACT [GOC:dos] +is_a: GO:0031960 ! response to corticosteroid + +[Term] +id: GO:0051385 +name: response to mineralocorticoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:ai, PMID:9884123] +synonym: "response to mineralocorticoid stimulus" EXACT [GOC:dos] +is_a: GO:0031960 ! response to corticosteroid + +[Term] +id: GO:0051386 +name: regulation of neurotrophin TRK receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] +synonym: "regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] +synonym: "regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "regulation of NGF receptor signaling pathway" EXACT [] +synonym: "regulation of NGF receptor signalling pathway" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway + +[Term] +id: GO:0051387 +name: negative regulation of neurotrophin TRK receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] +synonym: "down regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "down-regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "downregulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "inhibition of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "negative regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] +synonym: "negative regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "negative regulation of NGF receptor signaling pathway" EXACT [] +synonym: "negative regulation of NGF receptor signalling pathway" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +relationship: negatively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway + +[Term] +id: GO:0051388 +name: positive regulation of neurotrophin TRK receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway." [GOC:ai] +synonym: "activation of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "positive regulation of nerve growth factor receptor signaling pathway" RELATED [GOC:jc] +synonym: "positive regulation of nerve growth factor receptor signalling pathway" EXACT [] +synonym: "positive regulation of NGF receptor signaling pathway" EXACT [] +synonym: "positive regulation of NGF receptor signalling pathway" EXACT [] +synonym: "stimulation of nerve growth factor receptor signaling pathway" NARROW [] +synonym: "up regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "up-regulation of nerve growth factor receptor signaling pathway" EXACT [] +synonym: "upregulation of nerve growth factor receptor signaling pathway" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0051386 ! regulation of neurotrophin TRK receptor signaling pathway +relationship: positively_regulates GO:0048011 ! neurotrophin TRK receptor signaling pathway + +[Term] +id: GO:0051389 +name: obsolete inactivation of MAPKK activity +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase (MAPKK)." [GOC:ai] +comment: This term was obsoleted because it represents a molecular function. +synonym: "inactivation of MAP kinase kinase activity" EXACT [] +synonym: "termination of MAP kinase kinase activity" EXACT [] +synonym: "termination of MAPKK activity" EXACT [] +is_obsolete: true +consider: GO:0030291 +consider: GO:0043409 + +[Term] +id: GO:0051390 +name: obsolete inactivation of MAPKKK activity +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase kinase kinase (MAPKKK)." [GOC:ai] +comment: This term was obsoleted because it represents a molecular function. +synonym: "inactivation of MAP kinase kinase kinase activity" EXACT [] +synonym: "termination of MAP kinase kinase kinase activity" EXACT [] +synonym: "termination of MAPKKK activity" EXACT [] +is_obsolete: true +consider: GO:0030291 +consider: GO:0043409 + +[Term] +id: GO:0051391 +name: tRNA acetylation +namespace: biological_process +def: "The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] +is_a: GO:0006400 ! tRNA modification +is_a: GO:1990884 ! RNA acetylation + +[Term] +id: GO:0051392 +name: tRNA N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA." [PMID:15037780] +synonym: "tRNA cytidine N-acetyltransferase activity" EXACT [] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0051393 +name: alpha-actinin binding +namespace: molecular_function +alt_id: GO:0051372 +def: "Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." [PMID:10984498, PMID:11699871, PMID:15014165] +synonym: "alpha-actinin 1 binding" NARROW [] +synonym: "alpha-actinin 4 binding" NARROW [] +synonym: "nonmuscle alpha-actinin binding" NARROW [] +is_a: GO:0042805 ! actinin binding + +[Term] +id: GO:0051394 +name: regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] +synonym: "regulation of NGF receptor activity" EXACT [] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:0051395 +name: negative regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] +synonym: "down regulation of nerve growth factor receptor activity" EXACT [] +synonym: "down-regulation of nerve growth factor receptor activity" EXACT [] +synonym: "downregulation of nerve growth factor receptor activity" EXACT [] +synonym: "inhibition of nerve growth factor receptor activity" NARROW [] +synonym: "negative regulation of NGF receptor activity" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0051394 ! regulation of nerve growth factor receptor activity +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0051396 +name: positive regulation of nerve growth factor receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor." [GOC:ai] +synonym: "activation of nerve growth factor receptor activity" NARROW [] +synonym: "positive regulation of NGF receptor activity" EXACT [] +synonym: "stimulation of nerve growth factor receptor activity" NARROW [] +synonym: "up regulation of nerve growth factor receptor activity" EXACT [] +synonym: "up-regulation of nerve growth factor receptor activity" EXACT [] +synonym: "upregulation of nerve growth factor receptor activity" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0051394 ! regulation of nerve growth factor receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0051397 +name: obsolete N-terminal basic amino acid aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of basic amino acid residues at the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai] +comment: This term was made obsolete because it represents a gene product. +synonym: "N-terminal basic amino acid aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051398 +name: obsolete N-terminal lysine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of a lysine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] +comment: This term was made obsolete because it represents a gene product. +synonym: "lysine aminopeptidase activity" BROAD [] +synonym: "lysyl aminopeptidase activity" BROAD [] +synonym: "N-terminal lysine aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051399 +name: obsolete N-terminal arginine aminopeptidase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of an arginine residue from the N-terminal of an oligopeptide or polypeptide chain." [GOC:ai, PMID:12799365] +comment: This term was made obsolete because it represents a gene product. +synonym: "arginine aminopeptidase activity" BROAD [] +synonym: "argininyl aminopeptidase activity" BROAD [] +synonym: "N-terminal arginine aminopeptidase activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004177 + +[Term] +id: GO:0051400 +name: BH domain binding +namespace: molecular_function +def: "Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] +subset: goslim_chembl +synonym: "Bcl-2 homology domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051401 +name: CH domain binding +namespace: molecular_function +def: "Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins." [PMID:11911887, Prosite:PDOC50021] +synonym: "calponin homology domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051402 +name: neuron apoptotic process +namespace: biological_process +def: "Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [CL:0000540, GOC:mtg_apoptosis, MeSH:A.08.663] +synonym: "apoptosis of neuronal cells" EXACT [] +synonym: "apoptosis of neurons" EXACT [] +synonym: "neuron apoptosis" NARROW [] +synonym: "neuron programmed cell death by apoptosis" EXACT [] +synonym: "neuronal cell apoptosis" EXACT [] +synonym: "neuronal cell programmed cell death by apoptosis" EXACT [] +synonym: "programmed cell death of neuronal cells by apoptosis" EXACT [] +synonym: "programmed cell death of neurons by apoptosis" EXACT [] +synonym: "programmed cell death, neuronal cells" EXACT [] +synonym: "programmed cell death, neurons" EXACT [] +is_a: GO:0006915 ! apoptotic process +is_a: GO:0070997 ! neuron death + +[Term] +id: GO:0051403 +name: stress-activated MAPK cascade +namespace: biological_process +def: "A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase." [GOC:ai, PMID:15936270] +synonym: "MAPK11 cascade" NARROW [GOC:add] +synonym: "MAPK12 cascade" NARROW [GOC:add] +synonym: "MAPK13 cascade" NARROW [GOC:add] +synonym: "MAPK14 cascade" NARROW [GOC:add] +synonym: "p38 cascade" NARROW [GOC:add] +synonym: "p38 MAPK signaling" NARROW [] +synonym: "p38 MAPK signalling" NARROW [] +synonym: "SAPK cascade" BROAD [GOC:add] +synonym: "stress-activated MAPK signaling pathway" EXACT [] +synonym: "stress-activated MAPK signalling pathway" EXACT [] +synonym: "stress-activated MAPKKK cascade" EXACT [] +synonym: "stress-activated MAPKKK signaling pathway" EXACT [] +synonym: "stress-activated MAPKKK signalling pathway" EXACT [] +is_a: GO:0000165 ! MAPK cascade +is_a: GO:0031098 ! stress-activated protein kinase signaling cascade + +[Term] +id: GO:0051404 +name: obsolete clostripain activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the cleavage of Arg-Xaa bonds." [EC:3.4.22.8] +comment: This term was made obsolete because it represents a gene product. +synonym: "alpha-clostridipain" RELATED [EC:3.4.22.8] +synonym: "clostridiopeptidase B activity" EXACT [] +synonym: "Clostridium histolyticum proteinase B" RELATED [EC:3.4.22.8] +synonym: "clostripain activity" EXACT [] +is_obsolete: true +replaced_by: GO:0004197 + +[Term] +id: GO:0051405 +name: obsolete microbial collagenase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the digestion of native collagen in the triple helical region at Xaa-Gly bonds." [GOC:curators] +comment: This term was made obsolete because it represents a gene product. +synonym: "Achromobacter iophagus collagenase" RELATED [] +synonym: "aspergillopeptidase C" RELATED [] +synonym: "azocollase activity" RELATED [] +synonym: "clostridiopeptidase A activity" EXACT [] +synonym: "clostridiopeptidase I" RELATED [] +synonym: "clostridiopeptidase II" RELATED [] +synonym: "Clostridium histolyticum collagenase activity" NARROW [] +synonym: "Clostridium histolyticum proteinase A" RELATED [] +synonym: "collagen peptidase activity" RELATED [] +synonym: "collagen protease activity" RELATED [] +synonym: "collagenase 1 activity" EXACT [] +synonym: "collagenase A activity" EXACT [] +synonym: "collagenase I activity" RELATED [] +synonym: "collagenase MMP-1" RELATED [] +synonym: "kollaza" RELATED [] +synonym: "matirx metalloproteinase-18" RELATED [] +synonym: "matrix metalloproteinase-1" RELATED [] +synonym: "matrix metalloproteinase-8" RELATED [] +synonym: "metallocollagenase activity" RELATED [] +synonym: "metalloproteinase-1" RELATED [] +synonym: "microbial collagenase activity" EXACT [] +synonym: "nucleolysin" RELATED [] +synonym: "soycollagestin" RELATED [] +is_obsolete: true +replaced_by: GO:0004252 + +[Term] +id: GO:0051407 +name: glycerone phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerone phosphate(out) + phosphate(in) = glycerone phosphate(in) + phosphate(out)." [GOC:ai] +synonym: "dihydroxyacetone-phosphate:inorganic phosphate antiporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0051408 +name: glyceraldehyde 3-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glyceraldehyde 3-phosphate(out) + phosphate(in) = glyceraldehyde 3-phosphate(in) + phosphate(out)." [GOC:ai] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0009670 ! triose-phosphate:phosphate antiporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0051409 +name: response to nitrosative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0051410 +name: detoxification of nitrogen compound +namespace: biological_process +def: "Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:ai] +synonym: "detoxification of nitrogenous compound" EXACT [] +synonym: "nitric oxide (NO) detoxification" NARROW [] +is_a: GO:0098754 ! detoxification +relationship: part_of GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0051411 +name: obsolete ALP binding +namespace: molecular_function +def: "OBSOLETE. Interacting selectively and non-covalently wih ALP, actinin-associated LIM protein of the Z band. ALP is a PDZ/LIM domain protein found in the Z band." [PMID:11699871] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "actinin-associated LIM protein binding" EXACT [] +synonym: "ALP binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0051412 +name: response to corticosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [PMID:15240347] +synonym: "response to corticosterone stimulus" EXACT [GOC:dos] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:0051385 ! response to mineralocorticoid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0051413 +name: response to cortisone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [ISBN:0721662544, PMID:11276391] +synonym: "response to cortisone stimulus" EXACT [GOC:dos] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0051414 +name: response to cortisol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [ISBN:0721662544, PMID:11276391] +synonym: "response to cortisol stimulus" EXACT [GOC:dos] +synonym: "response to hydrocortisone stimulus" EXACT [] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0051415 +name: microtubule nucleation by interphase microtubule organizing center +namespace: biological_process +def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] +synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] +synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] +synonym: "interphase microtubule nucleation by interphase microtubule organizing center" EXACT [] +synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] +synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] +synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center + +[Term] +id: GO:0051416 +name: obsolete myotilin binding +namespace: molecular_function +def: "OBSOLETE. Binding to myotilin, a structural component of the Z-discs in human skeletal and cardiac muscle. Its C-terminus contains two immunoglobulin-like domains and the unique N-terminal half has a serine-rich region, with numerous potential phosphorylation sites, and a stretch of hydrophobic amino acids. Myotilin forms homodimers and binds to alpha-actinin, F-actin, and filamin C." [PMID:11699871, PMID:15752755] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "myotilin binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0051417 +name: microtubule nucleation by spindle pole body +namespace: biological_process +def: "The 'de novo' formation of a microtubule, mediated by the spindle pole body." [GOC:ai] +synonym: "microtubule nucleation by SPB" EXACT [] +synonym: "SPB-mediated microtubule nucleation" EXACT [] +synonym: "spindle pole body-mediated microtubule nucleation" EXACT [] +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center + +[Term] +id: GO:0051418 +name: microtubule nucleation by microtubule organizing center +namespace: biological_process +def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] +synonym: "microtubule nucleation by microtubule organising centre" EXACT [] +synonym: "microtubule nucleation by MTOC" EXACT [] +synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] +synonym: "MTOC-mediated microtubule nucleation" EXACT [] +is_a: GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0051419 +name: obsolete nebulin binding +namespace: molecular_function +def: "OBSOLETE. Binding to nebulin, a large protein (approximately 800kD) that is anchored at the Z-disc by its C-terminal region and spans the length of the thin filament, ending at the edge of the H-zone." [PMID:11699871] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "nebulin binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0051420 +name: obsolete nebulette binding +namespace: molecular_function +def: "OBSOLETE. Binding to nebulette, a 107 kDa protein associated with the I-Z-I complex of cardiac myofibrils. It shows a high degree of homology with skeletal muscle nebulin." [PMID:11699871] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "nebulette binding" EXACT [] +is_obsolete: true +replaced_by: GO:0008092 + +[Term] +id: GO:0051421 +name: regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "endo-1,4-beta-xylanase regulator" RELATED [] +synonym: "xylanase regulator" RELATED [] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0051422 +name: negative regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that stops or reduces the rate of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "down regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "down-regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "downregulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "endo-1,4-beta-xylanase inhibitor" RELATED [] +synonym: "inhibition of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "xylanase inhibitor" RELATED [] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity + +[Term] +id: GO:0051423 +name: positive regulation of endo-1,4-beta-xylanase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endo-(1->4)-beta-xylanase activity, the catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8, GOC:ai] +synonym: "activation of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "endo-1,4-beta-xylanase activator" RELATED [] +synonym: "stimulation of endo-1,4-beta-xylanase activity" NARROW [] +synonym: "up regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "up-regulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "upregulation of endo-1,4-beta-xylanase activity" EXACT [] +synonym: "xylanase activator" RELATED [] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0051421 ! regulation of endo-1,4-beta-xylanase activity + +[Term] +id: GO:0051424 +name: corticotropin-releasing hormone binding +namespace: molecular_function +alt_id: GO:0017047 +def: "Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [PMID:7556876] +synonym: "corticoliberin binding" EXACT [] +synonym: "corticotropin-releasing factor binding" EXACT [] +synonym: "CRF binding" EXACT [GOC:bf] +synonym: "CRH binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051425 +name: PTB domain binding +namespace: molecular_function +def: "Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain." [Pfam:PF02174.5, PMID:15924411] +synonym: "phosphotyrosine-interacting domain binding" EXACT [] +synonym: "PID binding" BROAD [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0051427 +name: hormone receptor binding +namespace: molecular_function +def: "Binding to a receptor for a hormone." [GOC:ai] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0051428 +name: peptide hormone receptor binding +namespace: molecular_function +def: "Binding to a receptor for a peptide hormone." [GOC:ai] +subset: goslim_chembl +synonym: "polypeptide hormone receptor binding" EXACT [] +is_a: GO:0051427 ! hormone receptor binding + +[Term] +id: GO:0051429 +name: corticotropin-releasing hormone receptor binding +namespace: molecular_function +alt_id: GO:0031742 +def: "Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland." [GOC:ai] +synonym: "corticotropin releasing factor receptor binding" EXACT [] +synonym: "corticotropin releasing factor receptor ligand" NARROW [] +synonym: "corticotropin-releasing factor receptor binding" EXACT [GOC:bf] +synonym: "CRF receptor binding" EXACT [GOC:bf] +synonym: "CRH receptor binding" EXACT [GOC:bf] +synonym: "CRHR binding" EXACT [GOC:bf] +is_a: GO:0051428 ! peptide hormone receptor binding +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0051430 +name: corticotropin-releasing hormone receptor 1 binding +namespace: molecular_function +alt_id: GO:0031743 +def: "Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857] +synonym: "CRHR1 binding" EXACT [] +synonym: "type 1 corticotropin releasing factor receptor binding" EXACT [] +synonym: "type 1 corticotropin releasing factor receptor ligand" NARROW [] +synonym: "type 1 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] +is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding + +[Term] +id: GO:0051431 +name: corticotropin-releasing hormone receptor 2 binding +namespace: molecular_function +alt_id: GO:0031744 +def: "Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery." [PMID:15134857] +synonym: "CRHR2 binding" EXACT [] +synonym: "type 2 corticotropin releasing factor receptor binding" EXACT [] +synonym: "type 2 corticotropin releasing factor receptor ligand" NARROW [] +synonym: "type 2 corticotropin-releasing factor receptor binding" EXACT [GOC:bf] +is_a: GO:0051429 ! corticotropin-releasing hormone receptor binding + +[Term] +id: GO:0051432 +name: BH1 domain binding +namespace: molecular_function +def: "Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01080] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051433 +name: BH2 domain binding +namespace: molecular_function +def: "Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01258] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051434 +name: BH3 domain binding +namespace: molecular_function +def: "Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] +subset: goslim_chembl +is_a: GO:0051400 ! BH domain binding +is_a: GO:0070513 ! death domain binding + +[Term] +id: GO:0051435 +name: BH4 domain binding +namespace: molecular_function +def: "Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein." [InterPro:IPR003093, PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01260, Prosite:PS50063] +is_a: GO:0051400 ! BH domain binding + +[Term] +id: GO:0051436 +name: obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] +synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] +synonym: "APC inhibition during mitotic cell cycle" NARROW [] +synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "mitotic anaphase promoting complex inhibition" NARROW [] +synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] +synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] +synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] +synonym: "mitotic APC inhibition" NARROW [] +synonym: "mitotic APC inhibitor" NARROW [] +synonym: "mitotic SCF complex inhibitor" NARROW [] +synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] +synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] +synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051437 +name: obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity that contributes to the regulation of the mitotic cell cycle phase transition." [GOC:ai, GOC:tb] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "activation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "mitotic SCF complex activator" NARROW [] +synonym: "mitotic ubiquitin ligase activator" NARROW [] +synonym: "positive regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] +synonym: "positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "stimulation of ubiquitin ligase activity during mitotic cell cycle" NARROW [] +synonym: "up regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +synonym: "up-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +synonym: "upregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] +is_obsolete: true + +[Term] +id: GO:0051438 +name: regulation of ubiquitin-protein transferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] +synonym: "anaphase-promoting complex regulator" NARROW [] +synonym: "APC regulator" NARROW [] +synonym: "regulation of ubiquitin transferase activity" EXACT [GOC:tb] +synonym: "SCF complex regulator" NARROW [] +synonym: "ubiquitin transferase regulator" RELATED [] +synonym: "ubiquitin-protein transferase regulator" RELATED [] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0051439 +name: obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai] +comment: false +synonym: "mitotic anaphase-promoting complex regulator" NARROW [] +synonym: "mitotic APC regulator" NARROW [] +synonym: "mitotic SCF complex regulator" NARROW [] +synonym: "mitotic ubiquitin ligase regulator" RELATED [] +synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] +synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] +synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051440 +name: obsolete regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle +namespace: biological_process +def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "meiotic anaphase-promoting complex regulator" NARROW [] +synonym: "meiotic APC regulator" NARROW [] +synonym: "meiotic SCF complex regulator" NARROW [] +synonym: "meiotic ubiquitin ligase regulator" RELATED [] +synonym: "meiotic ubiquitin-protein ligase regulator" RELATED [] +synonym: "regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] +synonym: "regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051441 +name: obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle +namespace: biological_process +alt_id: GO:0051487 +def: "OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:mah, GOC:tb, PMID:10871297] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "activation of anaphase-promoting complex activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "activation of anaphase-promoting complex activity involved in meiotic cell cycle" NARROW [] +synonym: "activation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle" RELATED [] +synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle" RELATED [] +synonym: "activation of ubiquitin ligase activity of APC during meiotic cell cycle" RELATED [] +synonym: "anaphase promoting complex activation during meiotic cell cycle" RELATED [] +synonym: "anaphase-promoting complex activation during meiotic cell cycle" RELATED [] +synonym: "APC activation during meiotic cell cycle" RELATED [] +synonym: "meiotic anaphase promoting complex activation" RELATED [] +synonym: "meiotic anaphase promoting complex activator" NARROW [] +synonym: "meiotic anaphase-promoting complex activator" NARROW [] +synonym: "meiotic APC activation" EXACT [] +synonym: "meiotic APC activator" NARROW [] +synonym: "meiotic SCF complex activator" NARROW [] +synonym: "meiotic ubiquitin ligase activator" NARROW [] +synonym: "positive regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] +synonym: "positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "stimulation of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "up regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +synonym: "up-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +synonym: "upregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +is_obsolete: true + +[Term] +id: GO:0051442 +name: obsolete negative regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity during the meiotic cell cycle." [GOC:ai, GOC:tb] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +synonym: "anaphase promoting complex inhibition during meiotic cell cycle" NARROW [] +synonym: "anaphase-promoting complex inhibition during meiotic cell cycle" NARROW [] +synonym: "APC inhibition during meiotic cell cycle" NARROW [] +synonym: "down regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +synonym: "down-regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +synonym: "downregulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [] +synonym: "inhibition of ubiquitin ligase activity during meiotic cell cycle" NARROW [] +synonym: "meiotic anaphase promoting complex inhibition" NARROW [] +synonym: "meiotic anaphase promoting complex inhibitor" NARROW [] +synonym: "meiotic anaphase-promoting complex inhibition" NARROW [] +synonym: "meiotic anaphase-promoting complex inhibitor" NARROW [] +synonym: "meiotic APC inhibition" NARROW [] +synonym: "meiotic APC inhibitor" NARROW [] +synonym: "meiotic SCF complex inhibitor" NARROW [] +synonym: "meiotic ubiquitin ligase inhibitor" NARROW [] +synonym: "negative regulation of ubiquitin ligase activity during meiotic cell cycle" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051443 +name: positive regulation of ubiquitin-protein transferase activity +namespace: biological_process +def: "Any process that activates, maintains or increases the rate of ubiquitin transferase activity." [GOC:ai, GOC:tb] +synonym: "activation of ubiquitin transferase activity" NARROW [] +synonym: "anaphase promoting complex activator" NARROW [] +synonym: "anaphase-promoting complex activator" NARROW [] +synonym: "APC activation" NARROW [] +synonym: "APC activator" NARROW [] +synonym: "positive regulation of ubiquitin transferase activity" EXACT [GOC:tb] +synonym: "SCF complex activator" NARROW [] +synonym: "stimulation of ubiquitin transferase activity" NARROW [] +synonym: "ubiquitin transferase activator" NARROW [] +synonym: "up regulation of ubiquitin ligase activity" RELATED [] +synonym: "up-regulation of ubiquitin transferase activity" EXACT [] +synonym: "upregulation of ubiquitin transferase activity" EXACT [] +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity + +[Term] +id: GO:0051444 +name: negative regulation of ubiquitin-protein transferase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] +synonym: "anaphase promoting complex inhibition" NARROW [] +synonym: "anaphase promoting complex inhibitor" NARROW [] +synonym: "anaphase-promoting complex inhibition" NARROW [] +synonym: "anaphase-promoting complex inhibitor" NARROW [] +synonym: "APC inhibition" NARROW [] +synonym: "APC inhibitor" NARROW [] +synonym: "down regulation of ubiquitin transferase activity" EXACT [] +synonym: "down-regulation of ubiquitin transferase activity" EXACT [] +synonym: "downregulation of ubiquitin transferase activity" EXACT [] +synonym: "inhibition of ubiquitin transferase activity" NARROW [] +synonym: "negative regulation of ubiquitin transferase activity" EXACT [GOC:tb] +synonym: "SCF complex inhibitor" NARROW [] +synonym: "ubiquitin transferase inhibitor" NARROW [] +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity + +[Term] +id: GO:0051445 +name: regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "meiotic cell cycle modulation" EXACT [] +synonym: "meiotic cell cycle regulation" EXACT [] +synonym: "meiotic cell cycle regulator" RELATED [] +synonym: "modulation of meiotic cell cycle progression" EXACT [] +synonym: "regulation of meiotic cell cycle progression" EXACT [] +synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051726 ! regulation of cell cycle +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051446 +name: positive regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "activation of progression through meiotic cell cycle" NARROW [] +synonym: "positive regulation of meiotic cell cycle progression" EXACT [] +synonym: "positive regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of progression through meiotic cell cycle" NARROW [] +synonym: "up regulation of progression through meiotic cell cycle" EXACT [] +synonym: "up-regulation of progression through meiotic cell cycle" EXACT [] +synonym: "upregulation of progression through meiotic cell cycle" EXACT [] +is_a: GO:0045787 ! positive regulation of cell cycle +is_a: GO:0051445 ! regulation of meiotic cell cycle +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051447 +name: negative regulation of meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of progression through meiotic cell cycle" EXACT [] +synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] +synonym: "downregulation of progression through meiotic cell cycle" EXACT [] +synonym: "inhibition of progression through meiotic cell cycle" NARROW [] +synonym: "negative regulation of meiotic cell cycle progression" EXACT [] +synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] +is_a: GO:0045786 ! negative regulation of cell cycle +is_a: GO:0051445 ! regulation of meiotic cell cycle +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:0051448 +name: gonadotropin-releasing hormone binding +namespace: molecular_function +def: "Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:pr, PMID:1984190] +synonym: "GnRH binding" EXACT [] +synonym: "gonadotrophin releasing hormone binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051449 +name: thyrotropin-releasing hormone binding +namespace: molecular_function +def: "Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system." [GOC:ai] +synonym: "thyrotropin releasing hormone binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0051450 +name: myoblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0051451 +name: myoblast migration +namespace: biological_process +def: "The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ai, GOC:mtg_muscle] +is_a: GO:0014812 ! muscle cell migration + +[Term] +id: GO:0051452 +name: intracellular pH reduction +namespace: biological_process +def: "Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] +synonym: "cell pH reduction" EXACT [] +synonym: "cellular acidification" EXACT [] +synonym: "intracellular acidification" RELATED [] +synonym: "reduction of cellular pH" EXACT [] +synonym: "reduction of pH in cell" EXACT [] +is_a: GO:0045851 ! pH reduction +is_a: GO:0051453 ! regulation of intracellular pH + +[Term] +id: GO:0051453 +name: regulation of intracellular pH +namespace: biological_process +def: "Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai, GOC:dph, GOC:tb] +synonym: "cell pH regulation" EXACT [] +synonym: "cellular pH regulation" EXACT [] +synonym: "pH regulation in cell" EXACT [] +synonym: "regulation of cell pH" EXACT [] +is_a: GO:0030641 ! regulation of cellular pH + +[Term] +id: GO:0051454 +name: intracellular pH elevation +namespace: biological_process +def: "Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion." [GOC:ai] +synonym: "cell pH elevation" EXACT [] +synonym: "cellular alkalinization" EXACT [] +synonym: "elevation of cellular pH" EXACT [] +synonym: "intracellular alkalinization" EXACT [] +synonym: "pH elevation in cell" EXACT [] +is_a: GO:0045852 ! pH elevation +is_a: GO:0051453 ! regulation of intracellular pH + +[Term] +id: GO:0051455 +name: monopolar spindle attachment to meiosis I kinetochore +namespace: biological_process +def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] +comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. +synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] +synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb] +synonym: "monopolar attachment" EXACT [] +synonym: "sister kinetochore mono-orientation" EXACT [] +is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0051456 +name: attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation +namespace: biological_process +def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis II. During meiosis II sister kinetochores are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore during meiosis II" RELATED [GOC:dph, GOC:tb] +synonym: "attachment of spindle microtubules to kinetochore involved in meiosis II" RELATED [GOC:dph, GOC:tb] +synonym: "meiotic bipolar attachment" RELATED [GOC:vw] +is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0051457 +name: maintenance of protein location in nucleus +namespace: biological_process +def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] +synonym: "maintenance of nuclear protein localization" EXACT [] +synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protein location in cell nucleus" EXACT [] +synonym: "nuclear protein retention" NARROW [] +synonym: "nuclear protein sequestering" NARROW [] +synonym: "nuclear protein sequestration" NARROW [] +synonym: "protein retention in nucleus" NARROW [] +synonym: "protein sequestration in nucleus" NARROW [] +synonym: "protein storage in nucleus" NARROW [] +synonym: "protein-nuclear retention" NARROW [] +synonym: "sequestration of protein in nucleus" NARROW [] +synonym: "storage of protein in nucleus" NARROW [] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:0051458 +name: corticotropin secretion +namespace: biological_process +def: "The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus." [GOC:cjm, PMID:11027914] +synonym: "ACTH secretion" EXACT [] +synonym: "adrenocorticotropic hormone secretion" EXACT [] +synonym: "adrenocorticotropin secretion" RELATED [GOC:dph, GOC:tb] +synonym: "adrenotropic hormone secretion" EXACT [] +synonym: "adrenotropin secretion" EXACT [] +synonym: "corticotropic hormone secretion" EXACT [] +is_a: GO:0030072 ! peptide hormone secretion +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0051459 +name: regulation of corticotropin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai, GOC:dph] +synonym: "regulation of ACTH secretion" EXACT [] +synonym: "regulation of adrenocorticotropic hormone secretion" EXACT [GOC:dph] +synonym: "regulation of adrenocorticotropin secretion" EXACT [] +synonym: "regulation of adrenotropin hormone secretion" EXACT [] +synonym: "regulation of adrenotropin secretion" EXACT [] +synonym: "regulation of corticotropic hormone secretion" EXACT [] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0051458 ! corticotropin secretion + +[Term] +id: GO:0051460 +name: negative regulation of corticotropin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell." [GOC:ai] +synonym: "down regulation of adrenocorticotropin secretion" EXACT [] +synonym: "down-regulation of adrenocorticotropin secretion" EXACT [] +synonym: "downregulation of adrenocorticotropin secretion" EXACT [] +synonym: "inhibition of adrenocorticotropin secretion" NARROW [] +synonym: "negative regulation of ACTH secretion" EXACT [] +synonym: "negative regulation of adrenocorticotropic hormone secretion" EXACT [] +synonym: "negative regulation of adrenocorticotropin secretion" EXACT [] +synonym: "negative regulation of adrenotropic hormone secretion" EXACT [] +synonym: "negative regulation of adrenotropin secretion" EXACT [] +synonym: "negative regulation of corticotropic hormone secretion" EXACT [] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0051459 ! regulation of corticotropin secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0051458 ! corticotropin secretion + +[Term] +id: GO:0051461 +name: positive regulation of corticotropin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell." [GOC:ai] +synonym: "activation of adrenocorticotropin secretion" NARROW [] +synonym: "positive regulation of ACTH secretion" EXACT [] +synonym: "positive regulation of adrenocorticotropic hormone secretion" EXACT [] +synonym: "positive regulation of adrenocorticotropin secretion" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of adrenotropic hormone secretion" EXACT [] +synonym: "positive regulation of adrenotropin secretion" EXACT [] +synonym: "positive regulation of corticotropic hormone secretion" EXACT [] +synonym: "stimulation of adrenocorticotropin secretion" NARROW [] +synonym: "up regulation of adrenocorticotropin secretion" EXACT [] +synonym: "up-regulation of adrenocorticotropin secretion" EXACT [] +synonym: "upregulation of adrenocorticotropin secretion" EXACT [] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0051459 ! regulation of corticotropin secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0051458 ! corticotropin secretion + +[Term] +id: GO:0051462 +name: regulation of cortisol secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] +is_a: GO:2000849 ! regulation of glucocorticoid secretion +relationship: regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051463 +name: negative regulation of cortisol secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] +synonym: "down regulation of cortisol secretion" EXACT [] +synonym: "down-regulation of cortisol secretion" EXACT [] +synonym: "downregulation of cortisol secretion" EXACT [] +synonym: "inhibition of cortisol secretion" NARROW [] +is_a: GO:0051462 ! regulation of cortisol secretion +is_a: GO:2000850 ! negative regulation of glucocorticoid secretion +relationship: negatively_regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051464 +name: positive regulation of cortisol secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of cortisol from a cell." [GOC:ai] +synonym: "activation of cortisol secretion" NARROW [] +synonym: "stimulation of cortisol secretion" NARROW [] +synonym: "up regulation of cortisol secretion" EXACT [] +synonym: "up-regulation of cortisol secretion" EXACT [] +synonym: "upregulation of cortisol secretion" EXACT [] +is_a: GO:0051462 ! regulation of cortisol secretion +is_a: GO:2000851 ! positive regulation of glucocorticoid secretion +relationship: positively_regulates GO:0043400 ! cortisol secretion + +[Term] +id: GO:0051465 +name: negative regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai] +synonym: "down regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "down-regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "downregulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "inhibition of corticotropin-releasing hormone secretion" NARROW [] +synonym: "negative regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "negative regulation of CRF secretion" EXACT [] +synonym: "negative regulation of CRH secretion" EXACT [] +is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0051466 +name: positive regulation of corticotropin-releasing hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin-releasing hormone from a cell." [GOC:ai] +synonym: "activation of corticotropin-releasing hormone secretion" NARROW [] +synonym: "positive regulation of corticotropin-releasing factor secretion" EXACT [] +synonym: "positive regulation of CRF secretion" EXACT [] +synonym: "positive regulation of CRH secretion" EXACT [] +synonym: "stimulation of corticotropin-releasing hormone secretion" NARROW [] +synonym: "up regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "up-regulation of corticotropin-releasing hormone secretion" EXACT [] +synonym: "upregulation of corticotropin-releasing hormone secretion" EXACT [] +is_a: GO:0043397 ! regulation of corticotropin-releasing hormone secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0043396 ! corticotropin-releasing hormone secretion + +[Term] +id: GO:0051467 +name: detection of steroid hormone stimulus +namespace: biological_process +def: "The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +is_a: GO:0009720 ! detection of hormone stimulus +is_a: GO:0048545 ! response to steroid hormone + +[Term] +id: GO:0051468 +name: detection of glucocorticoid hormone stimulus +namespace: biological_process +def: "The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:ai] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:0051467 ! detection of steroid hormone stimulus + +[Term] +id: GO:0051469 +name: vesicle fusion with vacuole +namespace: biological_process +alt_id: GO:0042146 +def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole." [GOC:ai] +synonym: "heterotypic vacuole fusion (non-autophagic)" RELATED [] +synonym: "heterotypic vacuole fusion, non-autophagic" RELATED [] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0097576 ! vacuole fusion + +[Term] +id: GO:0051470 +name: ectoine transport +namespace: biological_process +def: "The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:ai] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0051472 +name: glucosylglycerol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] +synonym: "glucosylglycerol metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019400 ! alditol metabolic process + +[Term] +id: GO:0051473 +name: glucosylglycerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai] +synonym: "glucosylglycerol anabolism" EXACT [] +synonym: "glucosylglycerol biosynthesis" EXACT [] +synonym: "glucosylglycerol formation" EXACT [] +synonym: "glucosylglycerol synthesis" EXACT [] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0019401 ! alditol biosynthetic process +is_a: GO:0051472 ! glucosylglycerol metabolic process + +[Term] +id: GO:0051474 +name: glucosylglycerol transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0015166 ! polyol transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0051475 +name: glucosylglycerol transport +namespace: biological_process +def: "The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0051476 +name: mannosylglycerate transport +namespace: biological_process +def: "The directed movement of mannosylglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:0051477 +name: mannosylglycerate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a mannosylglycerate from one side of a membrane to the other." [GOC:ai, PMID:15034926] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0051478 +name: mannosylglycerate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai, PMID:11562374] +synonym: "mannosylglycerate metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0051479 +name: mannosylglycerate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms." [GOC:ai] +synonym: "mannosylglycerate anabolism" EXACT [] +synonym: "mannosylglycerate biosynthesis" EXACT [] +synonym: "mannosylglycerate formation" EXACT [] +synonym: "mannosylglycerate synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0034637 ! cellular carbohydrate biosynthetic process +is_a: GO:0051478 ! mannosylglycerate metabolic process + +[Term] +id: GO:0051480 +name: regulation of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings." [GOC:ai, GOC:mah, GOC:rph] +synonym: "calcium ion homeostasis in cytoplasm" BROAD [] +synonym: "calcium ion homeostasis in cytosol" EXACT [] +synonym: "cytoplasmic calcium ion concentration regulation" BROAD [] +synonym: "cytoplasmic calcium ion homeostasis" BROAD [] +synonym: "cytosolic calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in cytoplasm" BROAD [] +synonym: "regulation of calcium ion concentration in cytosol" EXACT [] +synonym: "regulation of cytoplasmic calcium ion concentration" BROAD [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051481 +name: negative regulation of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the cytosol." [GOC:ai] +synonym: "cytoplasmic calcium ion concentration reduction" BROAD [] +synonym: "cytosolic calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in cytoplasm" BROAD [] +synonym: "reduction of calcium ion concentration in cytosol" EXACT [] +synonym: "reduction of cytoplasmic calcium ion concentration" BROAD [] +synonym: "reduction of cytosolic calcium ion concentration" EXACT [] +is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0051482 +name: positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol." [GOC:ai, GOC:signaling] +synonym: "elevation of calcium ion concentration in cytoplasm during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of calcium ion concentration in cytosol during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] +synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of cytoplasmic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" BROAD [] +synonym: "elevation of cytosolic calcium ion concentration during G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" RELATED [] +synonym: "elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger" EXACT [GOC:signaling] +synonym: "elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT [] +synonym: "positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway" EXACT [] +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +relationship: part_of GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0051483 +name: terpenoid biosynthetic process, mevalonate-independent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] +synonym: "mevalonate-independent terpene biosynthesis" NARROW [] +synonym: "mevalonate-independent terpene biosynthetic process" NARROW [] +synonym: "mevalonate-independent terpenoid biosynthesis" EXACT [] +synonym: "mevalonate-independent terpenoid biosynthetic process" EXACT [] +synonym: "terpene biosynthesis, mevalonate-independent" NARROW [] +synonym: "terpene biosynthetic process, mevalonate-independent" NARROW [] +synonym: "terpenoid anabolism, mevalonate-independent" EXACT [] +synonym: "terpenoid formation, mevalonate-independent" EXACT [] +synonym: "terpenoid synthesis, mevalonate-independent" EXACT [] +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0051484 +name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:ai] +synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism" RELATED [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process" RELATED [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis" RELATED [] +synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation" RELATED [] +synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis" RELATED [] +xref: MetaCyc:NONMEVIPP-PWY +is_a: GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway +relationship: part_of GO:0051483 ! terpenoid biosynthetic process, mevalonate-independent + +[Term] +id: GO:0051485 +name: terpenoid biosynthetic process, mevalonate-dependent +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] +synonym: "terpene biosynthesis, mevalonate-dependent" NARROW [] +synonym: "terpene biosynthetic process, mevalonate-dependent" NARROW [] +synonym: "terpenoid anabolism, mevalonate-dependent" EXACT [] +synonym: "terpenoid formation, mevalonate-dependent" EXACT [] +synonym: "terpenoid synthesis, mevalonate-dependent" EXACT [] +is_a: GO:0016114 ! terpenoid biosynthetic process + +[Term] +id: GO:0051486 +name: isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates." [GOC:ai] +synonym: "isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism" RELATED [] +synonym: "isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process" RELATED [GOC:dph, GOC:tb] +synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis" RELATED [] +synonym: "isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation" RELATED [] +synonym: "isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis" RELATED [] +is_a: GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway +relationship: part_of GO:0051485 ! terpenoid biosynthetic process, mevalonate-dependent + +[Term] +id: GO:0051489 +name: regulation of filopodium assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] +synonym: "regulation of filopodia biosynthesis" EXACT [] +synonym: "regulation of filopodia formation" EXACT [] +synonym: "regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0046847 ! filopodium assembly + +[Term] +id: GO:0051490 +name: negative regulation of filopodium assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai] +synonym: "down regulation of filopodium formation" EXACT [] +synonym: "down-regulation of filopodium formation" EXACT [] +synonym: "downregulation of filopodium formation" EXACT [] +synonym: "inhibition of filopodium formation" NARROW [] +synonym: "negative regulation of filopodia biosynthesis" EXACT [] +synonym: "negative regulation of filopodia formation" EXACT [] +synonym: "negative regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051489 ! regulation of filopodium assembly +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +relationship: negatively_regulates GO:0046847 ! filopodium assembly + +[Term] +id: GO:0051491 +name: positive regulation of filopodium assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone." [GOC:ai, GOC:dph, GOC:tb] +synonym: "activation of filopodium formation" NARROW [] +synonym: "positive regulation of filopodia biosynthesis" EXACT [] +synonym: "positive regulation of filopodia formation" EXACT [] +synonym: "positive regulation of filopodium formation" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of filopodium formation" NARROW [] +synonym: "up regulation of filopodium formation" EXACT [] +synonym: "up-regulation of filopodium formation" EXACT [] +synonym: "upregulation of filopodium formation" EXACT [] +is_a: GO:0051489 ! regulation of filopodium assembly +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +relationship: positively_regulates GO:0046847 ! filopodium assembly + +[Term] +id: GO:0051492 +name: regulation of stress fiber assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "regulation of stress fibre biosynthesis" RELATED [] +synonym: "regulation of stress fibre formation" EXACT [] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +is_a: GO:0110020 ! regulation of actomyosin structure organization +relationship: regulates GO:0043149 ! stress fiber assembly + +[Term] +id: GO:0051493 +name: regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "regulation of cytoskeleton organisation" EXACT [GOC:mah] +synonym: "regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051494 +name: negative regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "down regulation of cytoskeleton organization" EXACT [] +synonym: "down-regulation of cytoskeleton organization" EXACT [] +synonym: "downregulation of cytoskeleton organization" EXACT [] +synonym: "inhibition of cytoskeleton organization" NARROW [] +synonym: "negative regulation of cytoskeleton organisation" EXACT [GOC:mah] +synonym: "negative regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: negatively_regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051495 +name: positive regulation of cytoskeleton organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:ai] +synonym: "activation of cytoskeleton organization" NARROW [] +synonym: "positive regulation of cytoskeleton organisation" EXACT [GOC:mah] +synonym: "positive regulation of cytoskeleton organization and biogenesis" RELATED [GOC:mah] +synonym: "stimulation of cytoskeleton organization" NARROW [] +synonym: "up regulation of cytoskeleton organization" EXACT [] +synonym: "up-regulation of cytoskeleton organization" EXACT [] +synonym: "upregulation of cytoskeleton organization" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: positively_regulates GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0051496 +name: positive regulation of stress fiber assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "activation of stress fiber formation" NARROW [] +synonym: "positive regulation of stress fibre biosynthesis" RELATED [] +synonym: "positive regulation of stress fibre formation" RELATED [] +synonym: "stimulation of stress fiber formation" NARROW [] +synonym: "up regulation of stress fiber formation" RELATED [] +synonym: "up-regulation of stress fiber formation" EXACT [] +synonym: "upregulation of stress fiber formation" RELATED [] +is_a: GO:0032233 ! positive regulation of actin filament bundle assembly +is_a: GO:0051492 ! regulation of stress fiber assembly +relationship: positively_regulates GO:0043149 ! stress fiber assembly + +[Term] +id: GO:0051497 +name: negative regulation of stress fiber assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts." [GOC:ai] +synonym: "down regulation of stress fiber formation" RELATED [] +synonym: "down-regulation of stress fiber formation" EXACT [] +synonym: "downregulation of stress fiber formation" RELATED [] +synonym: "inhibition of stress fiber formation" NARROW [] +synonym: "negative regulation of stress fibre biosynthesis" RELATED [] +synonym: "negative regulation of stress fibre formation" RELATED [] +is_a: GO:0032232 ! negative regulation of actin filament bundle assembly +is_a: GO:0051492 ! regulation of stress fiber assembly +relationship: negatively_regulates GO:0043149 ! stress fiber assembly + +[Term] +id: GO:0051498 +name: syn-copalyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate." [MetaCyc:RXN-8528] +synonym: "diterpene cyclase activity" BROAD [] +xref: EC:5.5.1.14 +xref: MetaCyc:RXN-8528 +xref: RHEA:25524 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0051499 +name: D-aminoacyl-tRNA deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA." [PMID:14527667] +xref: EC:3.1.1.96 +xref: MetaCyc:RXN-15041 +xref: RHEA:13953 +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0051500 +name: D-tyrosyl-tRNA(Tyr) deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA." [PMID:14527667] +is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity + +[Term] +id: GO:0051501 +name: diterpene phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units." [GOC:ai, ISBN:0721662544] +synonym: "diterpene phytoalexin metabolism" EXACT [] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0051502 +name: diterpene phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses." [GOC:ai] +synonym: "diterpene phytoalexin anabolism" EXACT [] +synonym: "diterpene phytoalexin biosynthesis" EXACT [] +synonym: "diterpene phytoalexin formation" EXACT [] +synonym: "diterpene phytoalexin synthesis" EXACT [] +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:0051501 ! diterpene phytoalexin metabolic process +is_a: GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0051503 +name: adenine nucleotide transport +namespace: biological_process +def: "The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0015865 ! purine nucleotide transport + +[Term] +id: GO:0051504 +name: diterpene phytoalexin precursor biosynthetic process pathway +namespace: biological_process +def: "A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins." [MetaCyc:PWY-2981] +synonym: "diterpene phytoalexin precursor anabolism pathway" EXACT [] +synonym: "diterpene phytoalexin precursor formation pathway" EXACT [] +synonym: "diterpene phytoalexin precursor synthesis pathway" EXACT [] +xref: MetaCyc:PWY-2981 +is_a: GO:0046246 ! terpene biosynthetic process +relationship: part_of GO:0051502 ! diterpene phytoalexin biosynthetic process + +[Term] +id: GO:0051506 +name: ergosterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol." [GOC:ai, RHEA:61836] +xref: MetaCyc:RXN-16975) +xref: RHEA:61836 +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051507 +name: beta-sitosterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol." [GOC:ai, RHEA:61832] +xref: MetaCyc:RXN-12128 +xref: RHEA:61832 +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051508 +name: stigmasterol UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol." [GOC:ai, RHEA:61828] +xref: MetaCyc:RXN-12126 +xref: RHEA:61828 +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051509 +name: tomatidine UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine." [GOC:ai] +is_a: GO:0016906 ! sterol 3-beta-glucosyltransferase activity + +[Term] +id: GO:0051510 +name: regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +synonym: "regulation of cell elongation" NARROW [] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051511 +name: negative regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +synonym: "down regulation of unidimensional cell growth" EXACT [] +synonym: "down-regulation of unidimensional cell growth" EXACT [] +synonym: "downregulation of unidimensional cell growth" EXACT [] +synonym: "inhibition of unidimensional cell growth" NARROW [] +synonym: "negative regulation of cell elongation" NARROW [] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: negatively_regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051512 +name: positive regulation of unidimensional cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] +synonym: "activation of unidimensional cell growth" NARROW [] +synonym: "positive regulation of cell elongation" NARROW [] +synonym: "stimulation of unidimensional cell growth" NARROW [] +synonym: "up regulation of unidimensional cell growth" EXACT [] +synonym: "up-regulation of unidimensional cell growth" EXACT [] +synonym: "upregulation of unidimensional cell growth" EXACT [] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: positively_regulates GO:0009826 ! unidimensional cell growth + +[Term] +id: GO:0051513 +name: regulation of monopolar cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051514 +name: negative regulation of monopolar cell growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +synonym: "down regulation of monopolar cell growth" EXACT [] +synonym: "down-regulation of monopolar cell growth" EXACT [] +synonym: "downregulation of monopolar cell growth" EXACT [] +synonym: "inhibition of monopolar cell growth" NARROW [] +is_a: GO:0051511 ! negative regulation of unidimensional cell growth +is_a: GO:0051513 ! regulation of monopolar cell growth +relationship: negatively_regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051515 +name: positive regulation of monopolar cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +synonym: "stimulation of monopolar cell growth" NARROW [] +synonym: "up regulation of monopolar cell growth" EXACT [] +synonym: "up-regulation of monopolar cell growth" EXACT [] +synonym: "upregulation of monopolar cell growth" EXACT [] +is_a: GO:0051512 ! positive regulation of unidimensional cell growth +is_a: GO:0051513 ! regulation of monopolar cell growth +relationship: positively_regulates GO:0042814 ! monopolar cell growth + +[Term] +id: GO:0051516 +name: regulation of bipolar cell growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +is_a: GO:0051510 ! regulation of unidimensional cell growth +relationship: regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051517 +name: negative regulation of bipolar cell growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +synonym: "down regulation of bipolar cell growth" EXACT [] +synonym: "down-regulation of bipolar cell growth" EXACT [] +synonym: "downregulation of bipolar cell growth" EXACT [] +synonym: "inhibition of bipolar cell growth" NARROW [] +is_a: GO:0051511 ! negative regulation of unidimensional cell growth +is_a: GO:0051516 ! regulation of bipolar cell growth +relationship: negatively_regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051518 +name: positive regulation of bipolar cell growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +synonym: "stimulation of bipolar cell growth" NARROW [] +synonym: "up regulation of bipolar cell growth" EXACT [] +synonym: "up-regulation of bipolar cell growth" EXACT [] +synonym: "upregulation of bipolar cell growth" EXACT [] +is_a: GO:0051512 ! positive regulation of unidimensional cell growth +is_a: GO:0051516 ! regulation of bipolar cell growth +relationship: positively_regulates GO:0042815 ! bipolar cell growth + +[Term] +id: GO:0051519 +name: activation of bipolar cell growth +namespace: biological_process +def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +is_a: GO:0051518 ! positive regulation of bipolar cell growth + +[Term] +id: GO:0051520 +name: termination of bipolar cell growth +namespace: biological_process +def: "Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] +is_a: GO:0051517 ! negative regulation of bipolar cell growth + +[Term] +id: GO:0051521 +name: termination of monopolar cell growth +namespace: biological_process +def: "Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051514 ! negative regulation of monopolar cell growth + +[Term] +id: GO:0051522 +name: activation of monopolar cell growth +namespace: biological_process +def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] +is_a: GO:0051515 ! positive regulation of monopolar cell growth + +[Term] +id: GO:0051523 +name: cell growth mode switching, monopolar to bipolar +namespace: biological_process +def: "The process in which a cell switches from monopolar cell growth to bipolar cell growth." [GOC:ai] +synonym: "NETO" NARROW [GOC:vw] +synonym: "new end take off" NARROW [GOC:vw] +is_a: GO:0061171 ! establishment of bipolar cell polarity +is_a: GO:0061389 ! regulation of direction of cell growth + +[Term] +id: GO:0051524 +name: cell growth mode switching, bipolar to monopolar +namespace: biological_process +def: "The process in which a cell switches from bipolar cell growth to monopolar cell growth." [GOC:ai] +is_a: GO:0061162 ! establishment of monopolar cell polarity +is_a: GO:0061389 ! regulation of direction of cell growth + +[Term] +id: GO:0051525 +name: NFAT protein binding +namespace: molecular_function +alt_id: GO:0051526 +alt_id: GO:0051527 +alt_id: GO:0051528 +alt_id: GO:0051529 +alt_id: GO:0051530 +def: "Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system." [PMID:15928679] +synonym: "NFAT binding" EXACT [] +synonym: "NFAT1 protein binding" NARROW [] +synonym: "NFAT2 protein binding" NARROW [] +synonym: "NFAT3 protein binding" NARROW [] +synonym: "NFAT4 protein binding" NARROW [] +synonym: "NFAT5 protein binding" NARROW [] +synonym: "NFATc binding" NARROW [] +synonym: "NFATc1 binding" NARROW [] +synonym: "NFATc2 binding" NARROW [] +synonym: "NFATc3 binding" NARROW [] +synonym: "NFATc4 binding" NARROW [] +synonym: "NFATp binding" NARROW [] +synonym: "NFATx binding" NARROW [] +synonym: "non-calcium-regulated NFAT protein binding" NARROW [] +synonym: "nuclear factor of activated T cell protein binding" EXACT [] +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0051536 +name: iron-sulfur cluster binding +namespace: molecular_function +def: "Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] +subset: goslim_metagenomics +synonym: "Fe/S binding" EXACT [] +synonym: "iron sulfur cluster binding" EXACT [] +synonym: "iron sulphur cluster binding" EXACT [] +synonym: "iron-sulphur cluster binding" EXACT [] +is_a: GO:0051540 ! metal cluster binding + +[Term] +id: GO:0051537 +name: 2 iron, 2 sulfur cluster binding +namespace: molecular_function +def: "Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] +synonym: "2 Fe 2 S cluster binding" EXACT [] +synonym: "2 iron, 2 sulphur cluster binding" EXACT [] +synonym: "2Fe-2S cluster binding" EXACT [] +synonym: "diiron disulfide cluster binding" EXACT [] +synonym: "diiron disulphide cluster binding" EXACT [] +synonym: "iron-sulfur cluster 2Fe-2S binding" EXACT [] +synonym: "iron-sulphur cluster 2Fe-2S binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051538 +name: 3 iron, 4 sulfur cluster binding +namespace: molecular_function +def: "Binding to a 3 iron, 4 sulfur (3Fe-4S) cluster; this cluster consists of three iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. It is essentially a 4Fe-4S cluster with one iron missing." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] +synonym: "3 Fe 4 S cluster binding" EXACT [] +synonym: "3 iron, 4 sulphur cluster binding" EXACT [] +synonym: "3Fe-4S cluster binding" EXACT [] +synonym: "iron-sulfur cluster 3Fe-4S binding" EXACT [] +synonym: "iron-sulphur cluster 3Fe-4S binding" EXACT [] +synonym: "triiron tetrasulfide cluster binding" EXACT [] +synonym: "triiron tetrasulphide cluster binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051539 +name: 4 iron, 4 sulfur cluster binding +namespace: molecular_function +def: "Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands." [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster] +synonym: "4 Fe 4 S cluster binding" EXACT [] +synonym: "4 iron, 4 sulphur cluster binding" EXACT [] +synonym: "4Fe-4S cluster binding" EXACT [] +synonym: "iron-sulfur cluster 4Fe-4S binding" EXACT [] +synonym: "iron-sulphur cluster 4Fe-4S binding" EXACT [] +synonym: "tetrairon tetrasulfide cluster binding" EXACT [] +synonym: "tetrairon tetrasulphide cluster binding" EXACT [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:0051540 +name: metal cluster binding +namespace: molecular_function +def: "Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] +subset: goslim_pir +is_a: GO:0005488 ! binding + +[Term] +id: GO:0051541 +name: elastin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:curators] +synonym: "elastin metabolism" EXACT [] +is_a: GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:0051542 +name: elastin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries." [GOC:ai] +is_a: GO:0009101 ! glycoprotein biosynthetic process +is_a: GO:0051541 ! elastin metabolic process + +[Term] +id: GO:0051543 +name: regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051544 +name: positive regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +synonym: "activation of elastin biosynthetic process" NARROW [] +synonym: "stimulation of elastin biosynthetic process" NARROW [] +synonym: "up regulation of elastin biosynthetic process" EXACT [] +synonym: "up-regulation of elastin biosynthetic process" EXACT [] +synonym: "upregulation of elastin biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0051543 ! regulation of elastin biosynthetic process +relationship: positively_regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051545 +name: negative regulation of elastin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of elastin." [GOC:ai] +synonym: "down regulation of elastin biosynthetic process" EXACT [] +synonym: "down-regulation of elastin biosynthetic process" EXACT [] +synonym: "downregulation of elastin biosynthetic process" EXACT [] +synonym: "inhibition of elastin biosynthetic process" NARROW [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0051543 ! regulation of elastin biosynthetic process +relationship: negatively_regulates GO:0051542 ! elastin biosynthetic process + +[Term] +id: GO:0051546 +name: keratinocyte migration +namespace: biological_process +def: "The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another." [ISBN:0721662544] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0051547 +name: regulation of keratinocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of keratinocyte migration." [GOC:ai] +is_a: GO:0010632 ! regulation of epithelial cell migration +relationship: regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051548 +name: negative regulation of keratinocyte migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration." [GOC:ai] +synonym: "down regulation of keratinocyte migration" EXACT [] +synonym: "down-regulation of keratinocyte migration" EXACT [] +synonym: "downregulation of keratinocyte migration" EXACT [] +synonym: "inhibition of keratinocyte migration" NARROW [] +is_a: GO:0010633 ! negative regulation of epithelial cell migration +is_a: GO:0051547 ! regulation of keratinocyte migration +relationship: negatively_regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051549 +name: positive regulation of keratinocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of keratinocyte migration." [GOC:ai] +synonym: "activation of keratinocyte migration" NARROW [] +synonym: "stimulation of keratinocyte migration" NARROW [] +synonym: "up regulation of keratinocyte migration" EXACT [] +synonym: "up-regulation of keratinocyte migration" EXACT [] +synonym: "upregulation of keratinocyte migration" EXACT [] +is_a: GO:0010634 ! positive regulation of epithelial cell migration +is_a: GO:0051547 ! regulation of keratinocyte migration +relationship: positively_regulates GO:0051546 ! keratinocyte migration + +[Term] +id: GO:0051550 +name: aurone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides." [PMID:20035037] +synonym: "aurone metabolism" EXACT [] +synonym: "benzalcoumaran-3-one metabolic process" EXACT [] +synonym: "benzalcoumaran-3-one metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0042440 ! pigment metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0051551 +name: aurone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments." [GOC:ai, PMID:20035037] +synonym: "benzalcoumaran-3-one biosynthesis" EXACT [] +synonym: "benzalcoumaran-3-one biosynthetic process" EXACT [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051550 ! aurone metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0051552 +name: flavone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [PMID:18567791] +synonym: "2-phenyl-4H-1-benzopyran-4-one metabolic process" NARROW [] +synonym: "2-phenyl-4H-1-benzopyran-4-one metabolism" NARROW [] +synonym: "2-phenylchromone metabolic process" NARROW [] +synonym: "2-phenylchromone metabolism" NARROW [] +synonym: "flavone metabolism" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051553 +name: flavone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone)." [GOC:ai, PMID:18567791] +synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthesis" NARROW [] +synonym: "2-phenyl-4H-1-benzopyran-4-one biosynthetic process" NARROW [] +synonym: "2-phenylchromone biosynthesis" NARROW [] +synonym: "2-phenylchromone biosynthetic process" NARROW [] +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051552 ! flavone metabolic process + +[Term] +id: GO:0051554 +name: flavonol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [PMID:11402179] +synonym: "flavonol metabolism" EXACT [] +is_a: GO:0051552 ! flavone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0051555 +name: flavonol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities." [GOC:ai] +xref: MetaCyc:PWY-3101 +is_a: GO:0051553 ! flavone biosynthetic process +is_a: GO:0051554 ! flavonol metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0051556 +name: leucoanthocyanidin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] +synonym: "leucoanthocyanidin metabolism" EXACT [] +xref: MetaCyc:PWY1F-823 +is_a: GO:0009698 ! phenylpropanoid metabolic process +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0051557 +name: leucoanthocyanidin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids." [GOC:ai] +is_a: GO:0009699 ! phenylpropanoid biosynthetic process +is_a: GO:0009813 ! flavonoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0051556 ! leucoanthocyanidin metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0051558 +name: phlobaphene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] +synonym: "phlobaphene metabolism" EXACT [] +is_a: GO:0042440 ! pigment metabolic process + +[Term] +id: GO:0051559 +name: phlobaphene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols." [PMID:11402179] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0046148 ! pigment biosynthetic process +is_a: GO:0051558 ! phlobaphene metabolic process + +[Term] +id: GO:0051560 +name: mitochondrial calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings." [GOC:ai, GOC:mah] +synonym: "calcium ion homeostasis in mitochondria" EXACT [] +synonym: "calcium ion homeostasis in mitochondrion" EXACT [] +synonym: "mitochondrial calcium ion concentration regulation" EXACT [] +synonym: "regulation of calcium ion concentration in mitochondria" EXACT [] +synonym: "regulation of calcium ion concentration in mitochondrion" EXACT [] +synonym: "regulation of mitochondrial calcium ion concentration" EXACT [] +is_a: GO:0006874 ! cellular calcium ion homeostasis + +[Term] +id: GO:0051561 +name: positive regulation of mitochondrial calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in mitochondria." [GOC:ai] +synonym: "elevation of calcium ion concentration in mitochondria" EXACT [] +synonym: "elevation of calcium ion concentration in mitochondrion" EXACT [] +synonym: "elevation of mitochondrial calcium ion concentration" EXACT [] +synonym: "mitochondrial calcium ion concentration elevation" EXACT [] +is_a: GO:0051560 ! mitochondrial calcium ion homeostasis + +[Term] +id: GO:0051562 +name: negative regulation of mitochondrial calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in mitochondria." [GOC:ai] +synonym: "mitochondrial calcium ion concentration reduction" EXACT [] +synonym: "reduction of calcium ion concentration in mitochondria" EXACT [] +synonym: "reduction of calcium ion concentration in mitochondrion" EXACT [] +synonym: "reduction of mitochondrial calcium ion concentration" EXACT [] +is_a: GO:0051560 ! mitochondrial calcium ion homeostasis + +[Term] +id: GO:0051563 +name: smooth endoplasmic reticulum calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings." [GOC:ai, GOC:mah] +synonym: "calcium ion homeostasis in smooth endoplasmic reticulum" EXACT [] +synonym: "calcium ion homeostasis in smooth ER" EXACT [] +synonym: "regulation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "regulation of calcium ion concentration in smooth ER" EXACT [] +synonym: "regulation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "regulation of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration regulation" EXACT [] +synonym: "smooth ER calcium ion concentration regulation" EXACT [] +synonym: "smooth ER calcium ion homeostasis" EXACT [] +is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051564 +name: positive regulation of smooth endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] +synonym: "elevation of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "elevation of smooth endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "elevation of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration elevation" EXACT [] +is_a: GO:0032470 ! positive regulation of endoplasmic reticulum calcium ion concentration +is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051565 +name: negative regulation of smooth endoplasmic reticulum calcium ion concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum." [GOC:ai] +synonym: "reduction of calcium ion concentration in smooth endoplasmic reticulum" EXACT [] +synonym: "reduction of calcium ion concentration in smooth ER" EXACT [] +synonym: "reduction of smooth endoplasmic reticulum calcium ion concentration" EXACT [] +synonym: "reduction of smooth ER calcium ion concentration" EXACT [] +synonym: "smooth endoplasmic reticulum calcium ion concentration reduction" EXACT [] +synonym: "smooth ER calcium ion concentration reduction" EXACT [] +is_a: GO:0032471 ! negative regulation of endoplasmic reticulum calcium ion concentration +is_a: GO:0051563 ! smooth endoplasmic reticulum calcium ion homeostasis + +[Term] +id: GO:0051566 +name: anthocyanidin-3-glucoside rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP." [PMID:8130800] +synonym: "3RT activity" BROAD [] +synonym: "anthocyanidin 3-glucoside-rhamnosyltransferase activity" EXACT [] +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0051567 +name: histone H3-K9 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone." [GOC:ai, GOC:pr] +synonym: "histone H3 K9 methylation" EXACT [] +synonym: "histone H3K9me" EXACT [] +synonym: "histone lysine H3 K9 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation +is_a: GO:0061647 ! histone H3-K9 modification + +[Term] +id: GO:0051568 +name: histone H3-K4 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone." [GOC:ai, GOC:pr] +synonym: "histone H3 K4 methylation" EXACT [] +synonym: "histone H3K4me" EXACT [] +synonym: "histone lysine H3 K4 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0051569 +name: regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:ai] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051570 +name: regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051571 +name: positive regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] +synonym: "activation of histone H3-K4 methylation" NARROW [] +synonym: "stimulation of histone H3-K4 methylation" NARROW [] +synonym: "up regulation of histone H3-K4 methylation" EXACT [] +synonym: "up-regulation of histone H3-K4 methylation" EXACT [] +synonym: "upregulation of histone H3-K4 methylation" EXACT [] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0051569 ! regulation of histone H3-K4 methylation +relationship: positively_regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051572 +name: negative regulation of histone H3-K4 methylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3." [GOC:mah] +synonym: "down regulation of histone H3-K4 methylation" EXACT [] +synonym: "down-regulation of histone H3-K4 methylation" EXACT [] +synonym: "downregulation of histone H3-K4 methylation" EXACT [] +synonym: "inhibition of histone H3-K4 methylation" NARROW [] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0051569 ! regulation of histone H3-K4 methylation +relationship: negatively_regulates GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0051573 +name: negative regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +synonym: "down regulation of histone H3-K9 methylation" EXACT [] +synonym: "down-regulation of histone H3-K9 methylation" EXACT [] +synonym: "downregulation of histone H3-K9 methylation" EXACT [] +synonym: "inhibition of histone H3-K9 methylation" NARROW [] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: negatively_regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051574 +name: positive regulation of histone H3-K9 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." [GOC:ai] +synonym: "activation of histone H3-K9 methylation" NARROW [] +synonym: "stimulation of histone H3-K9 methylation" NARROW [] +synonym: "up regulation of histone H3-K9 methylation" EXACT [] +synonym: "up-regulation of histone H3-K9 methylation" EXACT [] +synonym: "upregulation of histone H3-K9 methylation" EXACT [] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: positively_regulates GO:0051567 ! histone H3-K9 methylation + +[Term] +id: GO:0051575 +name: 5'-deoxyribose-5-phosphate lyase activity +namespace: molecular_function +def: "Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site." [PMID:11251121, PMID:16120966] +synonym: "5'-deoxyribose phosphate activity" EXACT [] +synonym: "dRP lyase activity" BROAD [] +synonym: "dRPase activity" BROAD [] +is_a: GO:0016835 ! carbon-oxygen lyase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0051580 +name: regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +subset: goslim_synapse +synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of neurotransmitter reuptake" EXACT [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051581 +name: negative regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of neurotransmitter uptake" EXACT [] +synonym: "down-regulation of neurotransmitter uptake" EXACT [] +synonym: "downregulation of neurotransmitter uptake" EXACT [] +synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051589 ! negative regulation of neurotransmitter transport +relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051582 +name: positive regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "activation of neurotransmitter uptake" NARROW [] +synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of neurotransmitter uptake" NARROW [] +synonym: "up regulation of neurotransmitter uptake" EXACT [] +synonym: "up-regulation of neurotransmitter uptake" EXACT [] +synonym: "upregulation of neurotransmitter uptake" EXACT [] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051590 ! positive regulation of neurotransmitter transport +relationship: positively_regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051583 +name: dopamine uptake involved in synaptic transmission +namespace: biological_process +def: "The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] +synonym: "dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] +synonym: "dopamine reuptake involved in synaptic transmission" EXACT [] +is_a: GO:0051934 ! catecholamine uptake involved in synaptic transmission +is_a: GO:0090494 ! dopamine uptake +relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0051584 +name: regulation of dopamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the catecholamine neurotransmitter dopamine into a cell." [GOC:ai] +synonym: "regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission +relationship: regulates GO:0051583 ! dopamine uptake involved in synaptic transmission + +[Term] +id: GO:0051585 +name: negative regulation of dopamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell." [GOC:ai] +synonym: "down regulation of dopamine uptake involved in synaptic transmission" EXACT [] +synonym: "down-regulation of dopamine uptake involved in synaptic transmission" EXACT [] +synonym: "downregulation of dopamine uptake involved in synaptic transmission" EXACT [] +synonym: "negative regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission +is_a: GO:0051945 ! negative regulation of catecholamine uptake involved in synaptic transmission +relationship: negatively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission + +[Term] +id: GO:0051586 +name: positive regulation of dopamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of dopamine into a cell." [GOC:ai] +synonym: "activation of dopamine uptake involved in synaptic transmission" NARROW [] +synonym: "positive regulation of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of dopamine uptake involved in synaptic transmission" NARROW [] +synonym: "up regulation of dopamine uptake involved in synaptic transmission" EXACT [] +synonym: "up-regulation of dopamine uptake involved in synaptic transmission" EXACT [] +synonym: "upregulation of dopamine uptake involved in synaptic transmission" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051584 ! regulation of dopamine uptake involved in synaptic transmission +is_a: GO:0051944 ! positive regulation of catecholamine uptake involved in synaptic transmission +relationship: positively_regulates GO:0051583 ! dopamine uptake involved in synaptic transmission + +[Term] +id: GO:0051587 +name: inhibition of dopamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of dopamine into a cell." [GOC:ai] +synonym: "inhibition of dopamine import involved in synaptic transmission" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051585 ! negative regulation of dopamine uptake involved in synaptic transmission +is_a: GO:0051609 ! inhibition of neurotransmitter uptake + +[Term] +id: GO:0051588 +name: regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051589 +name: negative regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of neurotransmitter transport" EXACT [] +synonym: "down-regulation of neurotransmitter transport" EXACT [] +synonym: "downregulation of neurotransmitter transport" EXACT [] +synonym: "inhibition of neurotransmitter transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: negatively_regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051590 +name: positive regulation of neurotransmitter transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of neurotransmitter transport" NARROW [] +synonym: "stimulation of neurotransmitter transport" NARROW [] +synonym: "up regulation of neurotransmitter transport" EXACT [] +synonym: "up-regulation of neurotransmitter transport" EXACT [] +synonym: "upregulation of neurotransmitter transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051588 ! regulation of neurotransmitter transport +relationship: positively_regulates GO:0006836 ! neurotransmitter transport + +[Term] +id: GO:0051591 +name: response to cAMP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai] +synonym: "response to 3',5' cAMP" EXACT [] +synonym: "response to 3',5'-cAMP" EXACT [] +synonym: "response to adenosine 3',5'-cyclophosphate" EXACT [] +synonym: "response to cyclic AMP" EXACT [] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0051592 +name: response to calcium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] +synonym: "response to Ca2+ ion" EXACT [] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0051593 +name: response to folic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:ai] +synonym: "cellular response to folate" EXACT [GOC:mah] +synonym: "cellular response to vitamin B9" EXACT [GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0051594 +name: detection of glucose +namespace: biological_process +def: "The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal." [GOC:ai] +synonym: "glucose detection" EXACT [] +synonym: "glucose perception" RELATED [] +synonym: "glucose sensing" RELATED [] +is_a: GO:0009732 ! detection of hexose stimulus +is_a: GO:0009749 ! response to glucose + +[Term] +id: GO:0051595 +name: response to methylglyoxal +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:ai] +synonym: "response to pyruvaldehyde" EXACT [] +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0051596 +name: methylglyoxal catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] +synonym: "methylglyoxal breakdown" EXACT [] +synonym: "methylglyoxal catabolism" EXACT [] +synonym: "methylglyoxal degradation" EXACT [] +xref: MetaCyc:METHGLYUT-PWY +xref: MetaCyc:Methylglyoxal-Detoxification +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046185 ! aldehyde catabolic process + +[Term] +id: GO:0051597 +name: response to methylmercury +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:ai] +synonym: "response to CH3-Hg+" EXACT [] +synonym: "response to MeHg+" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0051598 +name: meiotic recombination checkpoint signaling +namespace: biological_process +alt_id: GO:0072462 +def: "A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes." [PMID:14718568] +synonym: "meiotic recombination checkpoint" EXACT [] +synonym: "pachytene checkpoint" EXACT [] +synonym: "signal transduction involved in meiotic recombination checkpoint" EXACT [] +is_a: GO:0033313 ! meiotic cell cycle checkpoint signaling +is_a: GO:0045835 ! negative regulation of meiotic nuclear division + +[Term] +id: GO:0051599 +name: response to hydrostatic pressure +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [Wikipedia:Hydrostatic_pressure] +synonym: "response to biomechanical stress" BROAD [] +synonym: "response to static fluid pressure" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0009415 ! response to water + +[Term] +id: GO:0051600 +name: regulation of endocytosis by exocyst localization +namespace: biological_process +def: "Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai, GOC:dph, GOC:tb] +synonym: "regulation of endocytosis by exocyst localisation" EXACT [GOC:mah] +synonym: "regulation of site selection of endocytosis" RELATED [] +synonym: "relocation of endocytosis" RELATED [] +synonym: "spatial regulation of endocytosis" RELATED [] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051601 ! exocyst localization + +[Term] +id: GO:0051601 +name: exocyst localization +namespace: biological_process +def: "Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:ai] +synonym: "establishment and maintenance of exocyst localization" EXACT [] +synonym: "exocyst localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0051602 +name: response to electrical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:ai] +synonym: "response to electricity" RELATED [] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0051603 +name: proteolysis involved in cellular protein catabolic process +namespace: biological_process +def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_yeast +synonym: "peptidolysis during cellular protein catabolic process" RELATED [] +synonym: "peptidolysis during cellular protein catabolism" RELATED [] +synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] +synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] +synonym: "proteolysis during cellular protein catabolic process" RELATED [] +synonym: "proteolysis during cellular protein catabolism" RELATED [] +is_a: GO:0006508 ! proteolysis +relationship: part_of GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:0051604 +name: protein maturation +namespace: biological_process +def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +subset: goslim_yeast +is_a: GO:0019538 ! protein metabolic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0051606 +name: detection of stimulus +namespace: biological_process +def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] +subset: goslim_pir +synonym: "perception of stimulus" RELATED [] +synonym: "stimulus detection" EXACT [] +synonym: "stimulus sensing" RELATED [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0051607 +name: defense response to virus +namespace: biological_process +def: "Reactions triggered in response to the presence of a virus that act to protect the cell or organism." [GOC:ai] +synonym: "antiviral response" EXACT [] +synonym: "defence response to virus" EXACT [] +synonym: "defense response to viruses" EXACT [] +is_a: GO:0009615 ! response to virus +is_a: GO:0140546 ! defense response to symbiont + +[Term] +id: GO:0051608 +name: histamine transport +namespace: biological_process +def: "The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +is_a: GO:0006812 ! cation transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0051609 +name: inhibition of neurotransmitter uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of a neurotransmitter into a cell." [GOC:ai] +synonym: "inhibition of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake + +[Term] +id: GO:0051610 +name: serotonin uptake +namespace: biological_process +def: "The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] +synonym: "5-HT uptake" EXACT [] +synonym: "5-hydroxytryptamine uptake" EXACT [] +synonym: "5HT uptake" EXACT [] +synonym: "serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006837 ! serotonin transport +is_a: GO:0098810 ! neurotransmitter reuptake + +[Term] +id: GO:0051611 +name: regulation of serotonin uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the monoamine neurotransmitter serotonin into a cell." [GOC:ai] +synonym: "regulation of 5-HT uptake" EXACT [] +synonym: "regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "regulation of 5HT uptake" EXACT [] +synonym: "regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051580 ! regulation of neurotransmitter uptake +relationship: regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051612 +name: negative regulation of serotonin uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "down regulation of serotonin uptake" EXACT [] +synonym: "down-regulation of serotonin uptake" EXACT [] +synonym: "downregulation of serotonin uptake" EXACT [] +synonym: "negative regulation of 5-HT uptake" EXACT [] +synonym: "negative regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "negative regulation of 5HT uptake" EXACT [] +synonym: "negative regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051611 ! regulation of serotonin uptake +relationship: negatively_regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051613 +name: positive regulation of serotonin uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "activation of serotonin uptake" NARROW [] +synonym: "positive regulation of 5-HT uptake" EXACT [] +synonym: "positive regulation of 5-hydroxytryptamine uptake" EXACT [] +synonym: "positive regulation of 5HT uptake" EXACT [] +synonym: "positive regulation of serotonin import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of serotonin uptake" NARROW [] +synonym: "up regulation of serotonin uptake" EXACT [] +synonym: "up-regulation of serotonin uptake" EXACT [] +synonym: "upregulation of serotonin uptake" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051611 ! regulation of serotonin uptake +relationship: positively_regulates GO:0051610 ! serotonin uptake + +[Term] +id: GO:0051614 +name: inhibition of serotonin uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of serotonin into a cell." [GOC:ai] +synonym: "inhibition of 5-HT uptake" EXACT [] +synonym: "inhibition of 5-hydroxytryptamine uptake" EXACT [] +synonym: "inhibition of 5HT uptake" EXACT [] +synonym: "inhibition of serotonin import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051612 ! negative regulation of serotonin uptake + +[Term] +id: GO:0051615 +name: histamine uptake +namespace: biological_process +def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +synonym: "histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0051608 ! histamine transport + +[Term] +id: GO:0051616 +name: regulation of histamine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] +synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051580 ! regulation of neurotransmitter uptake +relationship: regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051617 +name: negative regulation of histamine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "down regulation of histamine uptake" EXACT [] +synonym: "down-regulation of histamine uptake" EXACT [] +synonym: "downregulation of histamine uptake" EXACT [] +synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +relationship: negatively_regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051618 +name: positive regulation of histamine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "activation of histamine uptake" NARROW [] +synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of histamine uptake" NARROW [] +synonym: "up regulation of histamine uptake" EXACT [] +synonym: "up-regulation of histamine uptake" EXACT [] +synonym: "upregulation of histamine uptake" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +relationship: positively_regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051619 +name: inhibition of histamine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of histamine into a cell." [GOC:ai] +synonym: "inhibition of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051617 ! negative regulation of histamine uptake + +[Term] +id: GO:0051620 +name: norepinephrine uptake +namespace: biological_process +def: "The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai] +synonym: "levarterenol reuptake" EXACT [] +synonym: "levarterenol uptake" EXACT [] +synonym: "noradrenaline reuptake" EXACT [] +synonym: "noradrenaline uptake" EXACT [] +synonym: "norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "norepinephrine reuptake" EXACT [] +is_a: GO:0015874 ! norepinephrine transport +is_a: GO:0090493 ! catecholamine uptake + +[Term] +id: GO:0051621 +name: regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell." [GOC:ai] +synonym: "regulation of levarterenol uptake" EXACT [] +synonym: "regulation of noradrenaline uptake" EXACT [] +synonym: "regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051622 +name: negative regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "down regulation of norepinephrine uptake" EXACT [] +synonym: "down-regulation of norepinephrine uptake" EXACT [] +synonym: "downregulation of norepinephrine uptake" EXACT [] +synonym: "negative regulation of levarterenol uptake" EXACT [] +synonym: "negative regulation of noradrenaline uptake" EXACT [] +synonym: "negative regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051621 ! regulation of norepinephrine uptake +relationship: negatively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051623 +name: positive regulation of norepinephrine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "activation of norepinephrine uptake" NARROW [] +synonym: "positive regulation of levarterenol uptake" EXACT [] +synonym: "positive regulation of noradrenaline uptake" EXACT [] +synonym: "positive regulation of norepinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of norepinephrine uptake" NARROW [] +synonym: "up regulation of norepinephrine uptake" EXACT [] +synonym: "up-regulation of norepinephrine uptake" EXACT [] +synonym: "upregulation of norepinephrine uptake" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051621 ! regulation of norepinephrine uptake +relationship: positively_regulates GO:0051620 ! norepinephrine uptake + +[Term] +id: GO:0051624 +name: inhibition of norepinephrine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of norepinephrine into a cell." [GOC:ai] +synonym: "inhibition of levarterenol uptake" EXACT [] +synonym: "inhibition of noradrenaline uptake" EXACT [] +synonym: "inhibition of norepinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051622 ! negative regulation of norepinephrine uptake + +[Term] +id: GO:0051625 +name: epinephrine uptake +namespace: biological_process +def: "The directed movement of epinephrine into a cell, typically presynaptic neurons or glial cells. Epinephrine is a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:ai] +synonym: "adrenaline reuptake" EXACT [] +synonym: "adrenaline uptake" EXACT [] +synonym: "epinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "epinephrine reuptake" EXACT [] +is_a: GO:0048241 ! epinephrine transport +is_a: GO:0090493 ! catecholamine uptake + +[Term] +id: GO:0051626 +name: regulation of epinephrine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter epinephrine into a cell." [GOC:ai] +synonym: "regulation of adrenaline uptake" EXACT [] +synonym: "regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051627 +name: negative regulation of epinephrine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "down regulation of epinephrine uptake" EXACT [] +synonym: "down-regulation of epinephrine uptake" EXACT [] +synonym: "downregulation of epinephrine uptake" EXACT [] +synonym: "negative regulation of adrenaline uptake" EXACT [] +synonym: "negative regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051626 ! regulation of epinephrine uptake +relationship: negatively_regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051628 +name: positive regulation of epinephrine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "activation of epinephrine uptake" NARROW [] +synonym: "positive regulation of adrenaline uptake" EXACT [] +synonym: "positive regulation of epinephrine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of epinephrine uptake" NARROW [] +synonym: "up regulation of epinephrine uptake" EXACT [] +synonym: "up-regulation of epinephrine uptake" EXACT [] +synonym: "upregulation of epinephrine uptake" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051626 ! regulation of epinephrine uptake +relationship: positively_regulates GO:0051625 ! epinephrine uptake + +[Term] +id: GO:0051629 +name: inhibition of epinephrine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of epinephrine into a cell." [GOC:ai] +synonym: "inhibition of adrenaline uptake" EXACT [] +synonym: "inhibition of epinephrine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051627 ! negative regulation of epinephrine uptake + +[Term] +id: GO:0051630 +name: acetylcholine uptake +namespace: biological_process +def: "The directed movement of acetylcholine into a cell, typically presynaptic neurons or glial cells. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:ai] +synonym: "acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015870 ! acetylcholine transport +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0051631 +name: regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell." [GOC:ai] +synonym: "regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051632 +name: negative regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "down regulation of acetylcholine uptake" EXACT [] +synonym: "down-regulation of acetylcholine uptake" EXACT [] +synonym: "downregulation of acetylcholine uptake" EXACT [] +synonym: "negative regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051633 +name: positive regulation of acetylcholine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "activation of acetylcholine uptake" NARROW [] +synonym: "positive regulation of acetylcholine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of acetylcholine uptake" NARROW [] +synonym: "up regulation of acetylcholine uptake" EXACT [] +synonym: "up-regulation of acetylcholine uptake" EXACT [] +synonym: "upregulation of acetylcholine uptake" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051631 ! regulation of acetylcholine uptake +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0051630 ! acetylcholine uptake + +[Term] +id: GO:0051634 +name: inhibition of acetylcholine uptake +namespace: biological_process +def: "Any process that prevents the activation of the directed movement of acetylcholine into a cell." [GOC:ai] +synonym: "inhibition of acetylcholine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051609 ! inhibition of neurotransmitter uptake +is_a: GO:0051632 ! negative regulation of acetylcholine uptake + +[Term] +id: GO:0051635 +name: obsolete bacterial cell surface binding +namespace: molecular_function +alt_id: GO:0008367 +def: "OBSOLETE. Binding to a component on the surface of a bacterial cell." [GOC:ai] +comment: This term was made obsolete because it is ambiguous and causing confusion, and is an unnecessary grouping term. +synonym: "bacterial binding" EXACT [] +synonym: "bacterial cell surface binding" EXACT [] +synonym: "bacterium binding" EXACT [] +synonym: "bacterium cell surface binding" EXACT [] +synonym: "binding to bacterium" EXACT [] +is_obsolete: true +consider: GO:0003823 +consider: GO:0005102 +consider: GO:0042742 + +[Term] +id: GO:0051636 +name: obsolete Gram-negative bacterial cell surface binding +namespace: molecular_function +alt_id: GO:0008368 +def: "OBSOLETE. Binding to a component on the surface of a Gram-negative bacterial cell." [GOC:ai] +comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion. +synonym: "binding to Gram-negative bacterium" EXACT [] +synonym: "Gram-negative bacterial binding" EXACT [] +synonym: "Gram-negative bacterial cell surface binding" EXACT [] +synonym: "Gram-negative bacterium binding" EXACT [] +synonym: "Gram-negative bacterium cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0003823 +consider: GO:0050829 + +[Term] +id: GO:0051637 +name: obsolete Gram-positive bacterial cell surface binding +namespace: molecular_function +alt_id: GO:0051076 +def: "OBSOLETE. Binding to a component on the surface of a Gram-positive bacterium." [GOC:ai] +comment: This term was made obsolete because it is an unnecessary grouping term and was causing confusion. +synonym: "binding to Gram-positive bacterium" EXACT [] +synonym: "Gram-positive bacterial binding" EXACT [] +synonym: "Gram-positive bacterial cell surface binding" EXACT [] +synonym: "Gram-positive bacterium binding" EXACT [] +synonym: "Gram-positive bacterium cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0003823 +consider: GO:0050830 + +[Term] +id: GO:0051638 +name: barbed-end actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "barbed end actin filament uncapping" EXACT [] +synonym: "barbed end F-actin uncapping" EXACT [] +synonym: "barbed-end F-actin uncapping" EXACT [] +synonym: "plus end actin filament uncapping" EXACT [] +synonym: "plus end F-actin uncapping" EXACT [] +synonym: "plus-end actin filament uncapping" EXACT [] +synonym: "plus-end F-actin uncapping" EXACT [] +is_a: GO:0051695 ! actin filament uncapping + +[Term] +id: GO:0051639 +name: actin filament network formation +namespace: biological_process +def: "The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments." [GOC:ai] +synonym: "actin gel biosynthesis" EXACT [] +synonym: "actin gel formation" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0051640 +name: organelle localization +namespace: biological_process +def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] +subset: goslim_pir +synonym: "establishment and maintenance of organelle localization" EXACT [] +synonym: "organelle localisation" EXACT [GOC:mah] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051641 +name: cellular localization +namespace: biological_process +alt_id: GO:1902580 +def: "A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane." [GOC:tb, GOC:vw] +subset: goslim_pir +synonym: "cellular localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of cellular localization" EXACT [] +synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] +synonym: "intracellular localization" NARROW [] +synonym: "localization within cell" NARROW [] +synonym: "single organism cellular localization" EXACT [GOC:TermGenie] +synonym: "single-organism cellular localization" RELATED [] +is_a: GO:0009987 ! cellular process +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051642 +name: centrosome localization +namespace: biological_process +def: "Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "centrosome localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of centrosome localization" EXACT [] +is_a: GO:0061842 ! microtubule organizing center localization + +[Term] +id: GO:0051643 +name: endoplasmic reticulum localization +namespace: biological_process +def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah] +synonym: "ER localization" EXACT [GOC:dph] +synonym: "establishment and maintenance of ER localization" EXACT [] +is_a: GO:0051640 ! organelle localization +relationship: part_of GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0051644 +name: plastid localization +namespace: biological_process +def: "Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of plastid localization" EXACT [] +synonym: "plastid localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051645 +name: Golgi localization +namespace: biological_process +def: "Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of Golgi localization" EXACT [] +synonym: "Golgi apparatus localization" EXACT [] +synonym: "Golgi body localization" EXACT [] +synonym: "Golgi localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051646 +name: mitochondrion localization +namespace: biological_process +def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "establishment and maintenance of mitochondria localization" EXACT [] +synonym: "establishment and maintenance of mitochondrion localization" EXACT [] +synonym: "localization of mitochondria" EXACT [] +synonym: "localization of mitochondrion" EXACT [] +synonym: "mitochondria localization" EXACT [] +synonym: "mitochondrial localization" EXACT [] +synonym: "mitochondrion localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051647 +name: nucleus localization +namespace: biological_process +def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "cell nucleus localization" EXACT [] +synonym: "establishment and maintenance of nucleus localization" EXACT [] +synonym: "localization of nucleus" EXACT [] +synonym: "nucleus localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051648 +name: vesicle localization +namespace: biological_process +def: "Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:ai] +synonym: "cytoplasmic vesicle localization" EXACT [] +synonym: "establishment and maintenance of vesicle localization" EXACT [] +synonym: "vesicle localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051649 +name: establishment of localization in cell +namespace: biological_process +def: "Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation." [GOC:ai, GOC:dos, GOC:dph, GOC:tb] +synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] +synonym: "establishment of intracellular localization" NARROW [] +synonym: "establishment of localisation in cell" EXACT [GOC:mah] +synonym: "establishment of localization within cell" NARROW [] +synonym: "positioning within cell" NARROW [] +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0051641 ! cellular localization + +[Term] +id: GO:0051650 +name: establishment of vesicle localization +namespace: biological_process +def: "The directed movement of a vesicle to a specific location." [GOC:ai] +subset: goslim_aspergillus +synonym: "establishment of vesicle localisation" EXACT [GOC:mah] +is_a: GO:0051648 ! vesicle localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051651 +name: maintenance of location in cell +namespace: biological_process +def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] +synonym: "cellular retention" NARROW [] +synonym: "cellular sequestering" NARROW [] +synonym: "cellular storage" NARROW [] +synonym: "intracellular retention" NARROW [] +synonym: "intracellular sequestering" NARROW [] +synonym: "intracellular storage" NARROW [] +synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of intracellular localization" NARROW [] +synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of localization within cell" NARROW [] +synonym: "retention within cell" NARROW [] +synonym: "sequestering within cell" NARROW [] +synonym: "storage within cell" NARROW [] +is_a: GO:0009987 ! cellular process +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0051641 ! cellular localization + +[Term] +id: GO:0051652 +name: maintenance of chromosome location +namespace: biological_process +def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0050000 ! chromosome localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051653 +name: spindle localization +namespace: biological_process +def: "Any process in which is the spindle is transported to, and/or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of spindle localization" EXACT [] +synonym: "spindle localisation" EXACT [GOC:mah] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051654 +name: establishment of mitochondrion localization +namespace: biological_process +def: "The directed movement of the mitochondrion to a specific location." [GOC:ai] +synonym: "establishment of mitochondria localization" EXACT [] +synonym: "establishment of mitochondrion localisation" EXACT [GOC:mah] +synonym: "mitochondria positioning" EXACT [] +synonym: "mitochondrial migration" EXACT [] +synonym: "mitochondrion positioning" EXACT [] +is_a: GO:0051646 ! mitochondrion localization +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051655 +name: maintenance of vesicle location +namespace: biological_process +def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051648 ! vesicle localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051656 +name: establishment of organelle localization +namespace: biological_process +def: "The directed movement of an organelle to a specific location." [GOC:ai] +synonym: "establishment of organelle localisation" EXACT [GOC:mah] +is_a: GO:0051234 ! establishment of localization +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0051657 +name: maintenance of organelle location +namespace: biological_process +def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0051640 ! organelle localization + +[Term] +id: GO:0051658 +name: maintenance of nucleus location +namespace: biological_process +def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of cell nucleus location" EXACT [] +synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051647 ! nucleus localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051659 +name: maintenance of mitochondrion location +namespace: biological_process +def: "Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of mitochondria localization" EXACT [] +synonym: "maintenance of mitochondrion localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051646 ! mitochondrion localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051660 +name: establishment of centrosome localization +namespace: biological_process +def: "The directed movement of the centrosome to a specific location." [GOC:ai] +synonym: "centrosome positioning" EXACT [] +synonym: "establishment of centrosome localisation" EXACT [GOC:mah] +is_a: GO:0051642 ! centrosome localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051661 +name: maintenance of centrosome location +namespace: biological_process +def: "Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of centrosome localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051642 ! centrosome localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051663 +name: oocyte nucleus localization involved in oocyte dorsal/ventral axis specification +namespace: biological_process +alt_id: GO:0051662 +def: "The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte." [GOC:ai, GOC:dph, GOC:mtg_sensu, GOC:tb] +synonym: "establishment and maintenance of oocyte nucleus localization during oocyte axis determination" EXACT [] +synonym: "oocyte axis determination, oocyte nucleus localization" EXACT [] +synonym: "oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" EXACT [GOC:mah] +synonym: "oocyte nucleus localization during oocyte axis determination" RELATED [GOC:dph, GOC:tb] +synonym: "oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" EXACT [GOC:mah] +synonym: "oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" EXACT [GOC:dph, GOC:tb] +synonym: "oocyte nucleus localization involved in oocyte dorsoventral axis specification" EXACT [GOC:mah] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0051647 ! nucleus localization +relationship: part_of GO:0007310 ! oocyte dorsal/ventral axis specification + +[Term] +id: GO:0051664 +name: nuclear pore localization +namespace: biological_process +alt_id: GO:0031081 +def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai] +synonym: "establishment and maintenance of nuclear pore localization" EXACT [] +synonym: "nuclear pore distribution" RELATED [] +synonym: "nuclear pore localisation" EXACT [GOC:mah] +synonym: "positioning of nuclear pores" RELATED [] +is_a: GO:0006997 ! nucleus organization +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0051665 +name: membrane raft localization +namespace: biological_process +def: "Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:ai, PMID:16645198] +synonym: "establishment and maintenance of membrane raft localization" EXACT [] +synonym: "lipid raft localization" EXACT [] +synonym: "membrane raft localisation" EXACT [GOC:mah] +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0051666 +name: actin cortical patch localization +namespace: biological_process +def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah] +synonym: "actin cortical patch localisation" EXACT [GOC:mah] +synonym: "establishment and maintenance of actin cortical patch localization" EXACT [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051667 +name: establishment of plastid localization +namespace: biological_process +def: "The directed movement of a plastid to a specific location in the cell." [GOC:ai] +synonym: "establishment of plastid localisation" EXACT [GOC:mah] +is_a: GO:0051644 ! plastid localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051668 +name: localization within membrane +namespace: biological_process +def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] +synonym: "establishment and maintenance of localization in membrane" EXACT [] +synonym: "establishment and maintenance of position in membrane" EXACT [] +synonym: "localisation within membrane" EXACT [GOC:mah] +synonym: "localization to membrane" EXACT [] +synonym: "positioning within membrane" NARROW [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0051669 +name: fructan beta-fructosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans." [EC:3.2.1.80] +synonym: "beta-D-fructan fructohydrolase activity" RELATED [EC:3.2.1.80] +synonym: "exo-beta-D-fructosidase activity" EXACT [] +synonym: "exo-beta-fructosidase activity" EXACT [] +synonym: "fructan b-fructosidase activity" EXACT [] +synonym: "fructan exohydrolase activity" EXACT [] +synonym: "fructanase activity" RELATED [EC:3.2.1.80] +synonym: "polysaccharide beta-fructofuranosidase activity" EXACT [] +xref: EC:3.2.1.80 +xref: MetaCyc:3.2.1.80-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051670 +name: inulinase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin." [EC:3.2.1.7] +synonym: "2,1-beta-D-fructan fructanohydrolase activity" EXACT [] +synonym: "endo-inulinase activity" EXACT [] +synonym: "exoinulinase activity" EXACT [] +synonym: "indoinulinase activity" EXACT [] +synonym: "inulase activity" EXACT [] +xref: EC:3.2.1.7 +xref: MetaCyc:3.2.1.7-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051671 +name: obsolete induction of autolysin activity in other organism +namespace: biological_process +def: "OBSOLETE. Any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." [GOC:ai] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of autolysin activity in another organism" EXACT [] +synonym: "activation of autolysis in other organism" NARROW [] +synonym: "activation of autolytic activity in other organism" NARROW [] +synonym: "induction of autolysin activity in another organism" EXACT [GOC:bf] +synonym: "induction of autolysis in other organism" NARROW [] +synonym: "induction of autolytic activity in other organism" NARROW [] +synonym: "positive regulation of autolysin activity in another organism" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051672 +name: obsolete catabolism by organism of cell wall peptidoglycan in other organism +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of the cell wall peptidoglycans of another organism." [GOC:ai] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolic process of cell wall peptidoglycans of other organism" EXACT [] +synonym: "catabolism of cell wall peptidoglycans of other organism" EXACT [] +synonym: "cell wall catabolic process in other organism" NARROW [] +synonym: "cell wall catabolism in other organism" NARROW [] +synonym: "cell wall peptidoglycan catabolic process in another organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051673 +name: membrane disruption in another organism +namespace: biological_process +def: "The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism." [GOC:ai] +synonym: "cytolysis, by membrane disruption, in other organism" NARROW [] +synonym: "membrane disruption in other organism" EXACT [] +is_a: GO:0035821 ! modulation of process of another organism + +[Term] +id: GO:0051674 +name: localization of cell +namespace: biological_process +def: "Any process in which a cell is transported to, and/or maintained in, a specific location." [GOC:ai] +synonym: "cell localization" EXACT [] +synonym: "establishment and maintenance of cell localization" EXACT [] +synonym: "establishment and maintenance of localization of cell" EXACT [] +synonym: "localisation of cell" EXACT [GOC:mah] +is_a: GO:0009987 ! cellular process +is_a: GO:0051179 ! localization + +[Term] +id: GO:0051675 +name: isopullulanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)." [EC:3.2.1.57] +synonym: "pullulan 4-glucanohydrolase (isopanose-forming) activity" EXACT [] +xref: EC:3.2.1.57 +xref: MetaCyc:3.2.1.57-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0051676 +name: pullulan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [PMID:15013381] +synonym: "pullulan metabolism" EXACT [] +is_a: GO:0006073 ! cellular glucan metabolic process + +[Term] +id: GO:0051677 +name: pullulan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:0051676 ! pullulan metabolic process + +[Term] +id: GO:0051678 +name: pullulan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages." [GOC:ai] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0051676 ! pullulan metabolic process + +[Term] +id: GO:0051679 +name: 6-alpha-maltosylglucose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai, LIGAND:C03367, PubChem_Compound:439991] +synonym: "6-alpha-maltosylglucose metabolism" EXACT [] +synonym: "isopanose metabolic process" EXACT [] +synonym: "isopanose metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0051680 +name: 6-alpha-maltosylglucose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] +synonym: "isopanose biosynthesis" EXACT [] +synonym: "isopanose biosynthetic process" EXACT [] +is_a: GO:0009312 ! oligosaccharide biosynthetic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process + +[Term] +id: GO:0051681 +name: 6-alpha-maltosylglucose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose." [GOC:ai] +synonym: "isopanose catabolic process" EXACT [] +synonym: "isopanose catabolism" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0051679 ! 6-alpha-maltosylglucose metabolic process + +[Term] +id: GO:0051682 +name: galactomannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0051069 ! galactomannan metabolic process + +[Term] +id: GO:0051683 +name: establishment of Golgi localization +namespace: biological_process +def: "The directed movement of the Golgi to a specific location." [GOC:ai] +synonym: "establishment of Golgi apparatus localization" EXACT [] +synonym: "establishment of Golgi body localization" EXACT [] +synonym: "establishment of Golgi localisation" EXACT [GOC:mah] +is_a: GO:0051645 ! Golgi localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051684 +name: maintenance of Golgi location +namespace: biological_process +def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of Golgi apparatus localization" EXACT [] +synonym: "maintenance of Golgi body localization" EXACT [] +synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051645 ! Golgi localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051685 +name: maintenance of ER location +namespace: biological_process +def: "Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of endoplasmic reticulum localization" EXACT [] +synonym: "maintenance of ER localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051643 ! endoplasmic reticulum localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051686 +name: establishment of ER localization +namespace: biological_process +def: "The directed movement of the endoplasmic reticulum to a specific location." [GOC:ai] +synonym: "establishment of endoplasmic reticulum localization" EXACT [] +synonym: "establishment of ER localisation" EXACT [GOC:mah] +is_a: GO:0051643 ! endoplasmic reticulum localization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0051687 +name: maintenance of spindle location +namespace: biological_process +def: "Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of spindle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051653 ! spindle localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051688 +name: maintenance of plastid location +namespace: biological_process +def: "Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of plastid localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051644 ! plastid localization +is_a: GO:0051657 ! maintenance of organelle location + +[Term] +id: GO:0051691 +name: cellular oligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] +synonym: "cellular oligosaccharide metabolism" EXACT [] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044262 ! cellular carbohydrate metabolic process + +[Term] +id: GO:0051692 +name: cellular oligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells." [GOC:ai] +synonym: "cellular oligosaccharide breakdown" EXACT [] +synonym: "cellular oligosaccharide catabolism" EXACT [] +synonym: "cellular oligosaccharide degradation" EXACT [] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:0044275 ! cellular carbohydrate catabolic process +is_a: GO:0051691 ! cellular oligosaccharide metabolic process + +[Term] +id: GO:0051693 +name: actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "actin capping activity" RELATED [] +synonym: "F-actin capping activity" RELATED [] +is_a: GO:0030835 ! negative regulation of actin filament depolymerization +is_a: GO:0030837 ! negative regulation of actin filament polymerization + +[Term] +id: GO:0051694 +name: pointed-end actin filament capping +namespace: biological_process +def: "The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X] +synonym: "minus-end actin filament capping activity" EXACT [] +synonym: "minus-end F-actin capping activity" EXACT [] +synonym: "pointed-end actin capping activity" EXACT [] +synonym: "pointed-end F-actin capping activity" EXACT [] +is_a: GO:0051693 ! actin filament capping + +[Term] +id: GO:0051695 +name: actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "F-actin uncapping" EXACT [] +is_a: GO:0030836 ! positive regulation of actin filament depolymerization + +[Term] +id: GO:0051696 +name: pointed-end actin filament uncapping +namespace: biological_process +def: "The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits." [GOC:pf] +synonym: "minus end actin filament uncapping" EXACT [] +synonym: "minus end F-actin uncapping" EXACT [] +synonym: "minus-end actin filament uncapping" EXACT [] +synonym: "minus-end F-actin uncapping" EXACT [] +synonym: "pointed end actin filament uncapping" EXACT [] +synonym: "pointed end F-actin uncapping" EXACT [] +synonym: "pointed-end F-actin uncapping" EXACT [] +is_a: GO:0051695 ! actin filament uncapping + +[Term] +id: GO:0051697 +name: protein delipidation +namespace: biological_process +def: "The breakage of covalent bonds to detach lipid groups from a protein." [GOC:ai] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0051698 +name: saccharopine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2." [PMID:16233628] +synonym: "SAX activity" BROAD [] +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051699 +name: proline oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2." [MetaCyc:RXN-821] +xref: MetaCyc:RXN-821 +xref: RHEA:26124 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051700 +name: fructosyl-amino acid oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2." [PMID:16233628] +synonym: "FAOD activity" EXACT [] +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0051701 +name: biological process involved in interaction with host +namespace: biological_process +alt_id: GO:0044112 +alt_id: GO:0044116 +alt_id: GO:0044117 +alt_id: GO:0044119 +alt_id: GO:0044121 +alt_id: GO:0044123 +alt_id: GO:0044125 +def: "An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] +synonym: "growth of symbiont in host" NARROW [] +synonym: "growth of symbiont in host cell" NARROW [] +synonym: "growth of symbiont in host organelle" NARROW [] +synonym: "growth of symbiont in host vacuole" NARROW [] +synonym: "interaction with host" EXACT [] +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0051702 +name: biological process involved in interaction with symbiont +namespace: biological_process +def: "An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism." [GOC:cc] +synonym: "interaction with symbiont" RELATED [] +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0051703 +name: biological process involved in intraspecies interaction between organisms +namespace: biological_process +def: "Any process in which an organism has an effect on an organism of the same species." [GOC:ai] +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "intraspecies interaction between organisms" EXACT [] +synonym: "intraspecies interaction with other organisms" EXACT [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0051704 +name: obsolete multi-organism process +namespace: biological_process +alt_id: GO:0051706 +def: "OBSOLETE. A biological process which involves another organism of the same or different species." [GOC:jl] +comment: This term was obsoleted because it was not a biologically meaningful grouping class. +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "interaction between organisms" EXACT [] +synonym: "physiological interaction between organisms" EXACT [] +synonym: "physiological interaction with other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051705 +name: obsolete multi-organism behavior +namespace: biological_process +def: "OBSOLETE. Any process in which an organism has a behavioral effect on another organism of the same or different species." [GOC:ai] +comment: This term was obsoleted because it was an unnecessary grouping term. +subset: goslim_pir +synonym: "behavioral interaction between organisms" EXACT [] +synonym: "behavioral interaction with other organism" EXACT [] +synonym: "behavioral signaling" NARROW [] +synonym: "behavioral signalling" NARROW [GOC:mah] +synonym: "behavioural interaction between organisms" EXACT [] +synonym: "behavioural interaction with other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051707 +name: response to other organism +namespace: biological_process +alt_id: GO:0009613 +alt_id: GO:0042828 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism." [GOC:ai] +is_a: GO:0043207 ! response to external biotic stimulus +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms + +[Term] +id: GO:0051709 +name: regulation of killing of cells of another organism +namespace: biological_process +alt_id: GO:0044531 +alt_id: GO:0052248 +alt_id: GO:0052433 +alt_id: GO:0052459 +def: "Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +synonym: "modulation by organism of apoptotic process in other organism involved in symbiotic interaction" NARROW [] +synonym: "modulation of programmed cell death in other organism" NARROW [] +synonym: "modulation of programmed cell death in other organism involved in symbiotic interaction" NARROW [] +synonym: "regulation of killing of cells of other organism" EXACT [GOC:bf] +is_a: GO:0031341 ! regulation of cell killing +is_a: GO:0035821 ! modulation of process of another organism +relationship: regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051710 +name: regulation of cytolysis in another organism +namespace: biological_process +alt_id: GO:0001902 +def: "Any process that modulates the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] +synonym: "regulation of cytolysis in other organism" EXACT [] +synonym: "regulation of cytolysis of cells of another organism" EXACT [GOC:bf] +is_a: GO:0042268 ! regulation of cytolysis +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: regulates GO:0051715 ! cytolysis in another organism + +[Term] +id: GO:0051711 +name: negative regulation of killing of cells of another organism +namespace: biological_process +alt_id: GO:0052490 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +synonym: "down regulation of killing of cells of another organism" EXACT [] +synonym: "down-regulation of killing of cells of another organism" EXACT [] +synonym: "downregulation of killing of cells of another organism" EXACT [] +synonym: "inhibition of killing of cells of another organism" NARROW [] +synonym: "negative regulation of killing of cells of other organism" EXACT [] +is_a: GO:0031342 ! negative regulation of cell killing +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: negatively_regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051712 +name: positive regulation of killing of cells of another organism +namespace: biological_process +alt_id: GO:0052330 +alt_id: GO:0052388 +alt_id: GO:0052501 +alt_id: GO:0052518 +alt_id: GO:0052529 +def: "Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism." [GOC:ai] +synonym: "activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction" RELATED [] +synonym: "activation of killing of cells of another organism" NARROW [] +synonym: "enhancement of other organism programmed cell death by organism" RELATED [] +synonym: "positive regulation of killing of cells of other organism" EXACT [] +synonym: "stimulation of killing of cells of another organism" NARROW [] +synonym: "up regulation of killing of cells of another organism" EXACT [] +synonym: "up-regulation of killing of cells of another organism" EXACT [] +synonym: "upregulation of killing of cells of another organism" EXACT [] +is_a: GO:0031343 ! positive regulation of cell killing +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: positively_regulates GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051713 +name: negative regulation of cytolysis in another organism +namespace: biological_process +alt_id: GO:0001903 +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism." [GOC:ai] +synonym: "down regulation of cytolysis of cells of another organism" EXACT [] +synonym: "down-regulation of cytolysis of cells of another organism" EXACT [] +synonym: "downregulation of cytolysis of cells of another organism" EXACT [] +synonym: "inhibition of cytolysis of cells of another organism" NARROW [] +synonym: "negative regulation of cytolysis in other organism" EXACT [] +synonym: "negative regulation of cytolysis of cells of another organism" EXACT [GOC:bf] +is_a: GO:0045918 ! negative regulation of cytolysis +is_a: GO:0051710 ! regulation of cytolysis in another organism +is_a: GO:0051711 ! negative regulation of killing of cells of another organism +relationship: negatively_regulates GO:0051715 ! cytolysis in another organism + +[Term] +id: GO:0051714 +name: positive regulation of cytolysis in another organism +namespace: biological_process +alt_id: GO:0001904 +def: "Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism." [GOC:ai] +synonym: "activation of cytolysis of cells of another organism" NARROW [] +synonym: "positive regulation of cytolysis in other organism" EXACT [] +synonym: "positive regulation of cytolysis of cells of another organism" EXACT [GOC:bf] +synonym: "stimulation of cytolysis of cells of another organism" NARROW [] +synonym: "up regulation of cytolysis of cells of another organism" EXACT [] +synonym: "up-regulation of cytolysis of cells of another organism" EXACT [] +synonym: "upregulation of cytolysis of cells of another organism" EXACT [] +is_a: GO:0045919 ! positive regulation of cytolysis +is_a: GO:0051710 ! regulation of cytolysis in another organism +is_a: GO:0051712 ! positive regulation of killing of cells of another organism +relationship: positively_regulates GO:0051715 ! cytolysis in another organism + +[Term] +id: GO:0051715 +name: cytolysis in another organism +namespace: biological_process +alt_id: GO:0001901 +def: "The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:ai] +synonym: "cytolysis in other organism" EXACT [] +synonym: "cytolysis of cells of another organism" EXACT [GOC:bf] +is_a: GO:0019835 ! cytolysis +is_a: GO:0031640 ! killing of cells of another organism + +[Term] +id: GO:0051716 +name: cellular response to stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0009987 ! cellular process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0051717 +name: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:bf, MetaCyc:3.1.3.62-RXN] +synonym: "inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity" RELATED [EC:2.7.1.-] +synonym: "inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity" RELATED [EC:2.7.1.-] +synonym: "inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity" RELATED [EC:2.7.1.-] +xref: MetaCyc:3.1.3.62-RXN +xref: Reactome:R-HSA-1855200 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen" +xref: Reactome:R-HSA-1855205 "I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol" +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:0051718 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA)." [EC:2.1.1.37, PMID:15689527] +synonym: "HpaII methylase" NARROW [EC:2.1.1.37] +synonym: "HpaII' methylase" NARROW [EC:2.1.1.37] +synonym: "M.BsuRIa" NARROW [EC:2.1.1.37] +synonym: "M.BsuRIb" NARROW [EC:2.1.1.37] +xref: Reactome:R-HSA-5334151 "DNMT1 methylates cytosine in hemimethylated DNA" +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051719 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN." [EC:2.1.1.37, PMID:15689527] +xref: Reactome:R-HSA-5334097 "DNMT3B:DNMT3L methylates cytosine in DNA" +xref: Reactome:R-HSA-5334152 "DNMT3A:DNMT3L methylates cytosine in DNA" +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051720 +name: DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG." [EC:2.1.1.37, PMID:15689527] +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity + +[Term] +id: GO:0051721 +name: protein phosphatase 2A binding +namespace: molecular_function +def: "Binding to protein phosphatase 2A." [GOC:ai] +synonym: "protein phosphatase 2 binding" RELATED [GOC:rl] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:0051722 +name: protein C-terminal methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol." [PMID:10318862, PMID:8650216] +synonym: "protein phosphatase methylesterase activity" NARROW [] +xref: Reactome:R-HSA-8856951 "PP2A demethylation by PPME1" +is_a: GO:0051723 ! protein methylesterase activity + +[Term] +id: GO:0051723 +name: protein methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol." [GOC:ai] +synonym: "PME activity" RELATED [EC:2.7.1.-] +synonym: "protein carboxyl methylesterase activity" RELATED [EC:2.7.1.-] +synonym: "protein carboxylic ester hydrolase activity" EXACT [] +synonym: "protein methyl-esterase activity" RELATED [EC:2.7.1.-] +xref: Reactome:R-HSA-5367022 "DPH7 hydrolyzes a methyl group on Me-diphthine EEF2" +is_a: GO:0052689 ! carboxylic ester hydrolase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0051724 +name: NAD transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901368 +def: "Enables the transfer of NAD from one side of a membrane to the other." [GOC:TermGenie] +comment: NAD carrier +synonym: "NAD (oxidized) transporter activity" EXACT [] +synonym: "NAD (reduced) transporter activity" EXACT [] +synonym: "NAD transporter activity" RELATED [] +synonym: "NAD+ transporter activity" EXACT [] +synonym: "NADH transporter activity" EXACT [] +synonym: "nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "oxidized NAD transporter activity" EXACT [] +synonym: "oxidized nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +synonym: "reduced NAD transporter activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide transmembrane transporter activity" EXACT [] +is_a: GO:0015215 ! nucleotide transmembrane transporter activity + +[Term] +id: GO:0051725 +name: protein de-ADP-ribosylation +namespace: biological_process +def: "The process of removing one or more ADP-ribose residues from a protein." [GOC:ai] +synonym: "poly(ADP-ribose) removal from protein" EXACT [] +synonym: "protein amino acid de-ADP-ribosylation" EXACT [GOC:bf] +synonym: "protein poly(ADP-ribose) catabolic process" EXACT [] +synonym: "protein poly(ADP-ribose) catabolism" EXACT [] +synonym: "protein poly(ADP-ribose) degradation" EXACT [] +synonym: "protein poly(ADP-ribose) hydrolysis" EXACT [] +synonym: "removal of ADP-ribose from protein" EXACT [] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0051726 +name: regulation of cell cycle +namespace: biological_process +alt_id: GO:0000074 +alt_id: GO:0007050 +alt_id: GO:0071156 +alt_id: GO:0071157 +alt_id: GO:0071158 +alt_id: GO:0071850 +def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_yeast +synonym: "arrest of mitotic cell cycle progression" NARROW [GOC:mah] +synonym: "cell cycle arrest" NARROW [] +synonym: "cell cycle modulation" EXACT [] +synonym: "cell cycle regulation" EXACT [] +synonym: "cell cycle regulator" RELATED [] +synonym: "control of cell cycle progression" EXACT [] +synonym: "mitotic cell cycle arrest" NARROW [] +synonym: "modulation of cell cycle progression" EXACT [] +synonym: "negative regulation of cell cycle arrest" NARROW [] +synonym: "positive regulation of cell cycle arrest" NARROW [] +synonym: "regulation of cell cycle arrest" NARROW [] +synonym: "regulation of cell cycle progression" EXACT [] +synonym: "regulation of progression through cell cycle" EXACT [] +synonym: "tumor suppressor" RELATED [] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007049 ! cell cycle + +[Term] +id: GO:0051727 +name: obsolete cell cycle switching, meiotic to mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. The process in which a cell switches cell cycle mode from meiotic to mitotic division." [GOC:ai, GOC:mtg_cell_cycle] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "cell cycle switching, meiosis to mitosis" NARROW [] +synonym: "cell cycle switching, meiotic to mitotic cell cycle" EXACT [] +synonym: "conversion to mitosis" NARROW [] +synonym: "conversion to mitotic cell cycle" EXACT [] +synonym: "entry into mitosis" NARROW [] +synonym: "entry into mitotic cell cycle" EXACT [] +synonym: "initiation of mitosis" NARROW [] +synonym: "initiation of mitotic cell cycle" EXACT [] +synonym: "mitotic entry" NARROW [] +is_obsolete: true + +[Term] +id: GO:0051728 +name: cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +alt_id: GO:0042061 +def: "The process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai, GOC:mtg_cell_cycle] +synonym: "cell cycle switching, mitosis to meiosis" NARROW [] +synonym: "conversion to meiosis" NARROW [] +synonym: "conversion to meiotic cell cycle" EXACT [] +synonym: "entry into meiosis" NARROW [] +synonym: "entry into meiotic cell cycle" EXACT [] +synonym: "initiation of meiosis" NARROW [] +synonym: "initiation of meiotic cell cycle" EXACT [] +synonym: "meiotic entry" NARROW [] +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:0060184 ! cell cycle switching + +[Term] +id: GO:0051729 +name: germline cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "The process in which a germline cell switches cell cycle mode from mitotic to meiotic division." [GOC:ai] +synonym: "germline cell cycle switching, mitosis to meiosis" NARROW [] +synonym: "germline conversion to meiosis" NARROW [] +synonym: "germline conversion to meiotic cell cycle" EXACT [] +synonym: "germline entry into meiosis" NARROW [] +synonym: "germline entry into meiotic cell cycle" EXACT [] +synonym: "germline initiation of meiosis" NARROW [] +synonym: "germline initiation of meiotic cell cycle" EXACT [] +synonym: "germline meiotic entry" NARROW [] +is_a: GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0051730 +name: GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA." [EC:2.7.1.78, PMID:8428918] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "GTP-dependent polyribonucleotide kinase activity" EXACT [] +synonym: "GTP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP-dependent RNA kinase activity" EXACT [] +synonym: "GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051732 ! polyribonucleotide kinase activity +is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity + +[Term] +id: GO:0051731 +name: polynucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators] +synonym: "5'-dephosphopolynucleotide kinase activity" EXACT [] +synonym: "5'-hydroxyl polynucleotide kinase activity" EXACT [] +synonym: "PNK" RELATED [] +synonym: "polynucleotide 5'-hydroxy-kinase activity" EXACT [] +synonym: "polynucleotide 5'-hydroxyl kinase (phosphorylating) activity" EXACT [] +synonym: "polynucleotide kinase activity" BROAD [] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0051732 +name: polyribonucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA." [GOC:curators] +synonym: "5'-hydroxyl polyribonucleotide kinase activity" EXACT [] +synonym: "5'-hydroxyl RNA kinase activity" EXACT [] +synonym: "RNA 5'-hydroxyl kinase activity" EXACT [] +synonym: "RNA kinase activity" EXACT [] +is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity + +[Term] +id: GO:0051733 +name: polydeoxyribonucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA." [GOC:curators] +synonym: "DNA 5'-hydroxyl kinase activity" EXACT [] +synonym: "DNA kinase activity" EXACT [] +is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity + +[Term] +id: GO:0051734 +name: polynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [RHEA:54580] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP-dependent polynucleotide kinase activity" RELATED [] +synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphatase activity" RELATED [EC:2.7.1.78] +synonym: "ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] +xref: EC:2.7.1.78 +xref: RHEA:54580 +is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity + +[Term] +id: GO:0051735 +name: GTP-dependent polynucleotide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA." [GOC:curators] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051731 ! polynucleotide 5'-hydroxyl-kinase activity + +[Term] +id: GO:0051736 +name: polyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA." [EC:2.7.1.78] +synonym: "ATP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity" RELATED [] +synonym: "ATP-dependent polyribonucleotide kinase activity" EXACT [] +synonym: "ATP-dependent RNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "ATP-dependent RNA kinase activity" EXACT [] +synonym: "ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051732 ! polyribonucleotide kinase activity +is_a: GO:0051734 ! polynucleotide kinase activity + +[Term] +id: GO:0051737 +name: GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA." [EC:2.7.1.78, PMID:8428918] +synonym: "GTP-dependent DNA 5'-hydroxyl-kinase activity" EXACT [] +synonym: "GTP-dependent DNA kinase activity" EXACT [] +synonym: "GTP-dependent polydeoxyribonucleotide kinase activity" EXACT [] +synonym: "GTP-dependent polynucleotide 5'-hydroxyl-kinase activity" BROAD [] +synonym: "GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity" EXACT [] +is_a: GO:0051733 ! polydeoxyribonucleotide kinase activity +is_a: GO:0051735 ! GTP-dependent polynucleotide kinase activity + +[Term] +id: GO:0051738 +name: xanthophyll binding +namespace: molecular_function +def: "Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen." [ISBN:0122146743] +is_a: GO:0019840 ! isoprenoid binding +is_a: GO:0031409 ! pigment binding + +[Term] +id: GO:0051740 +name: ethylene binding +namespace: molecular_function +def: "Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:ai] +synonym: "ethene binding" EXACT [] +is_a: GO:0072328 ! alkene binding + +[Term] +id: GO:0051741 +name: 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2542] +synonym: "MPBQ methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-2542 +xref: RHEA:37979 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0051742 +name: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine." [MetaCyc:RXN-2762] +synonym: "MSBQ methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-2762 +xref: RHEA:37999 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0051743 +name: red chlorophyll catabolite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence." [PMID:10743659] +synonym: "RCC reductase activity" EXACT [] +xref: MetaCyc:RXN-7741 +xref: RHEA:24752 +is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0051744 +name: 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+." [MetaCyc:RXN1F-72] +xref: MetaCyc:RXN1F-72 +xref: RHEA:48884 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0051745 +name: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate." [EC:1.17.7.4] +synonym: "4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity" RELATED [EC:1.17.1.2] +synonym: "isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity" EXACT [] +xref: EC:1.17.7.4 +xref: MetaCyc:ISPH2-RXN +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0051746 +name: thalianol synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol)." [PMID:15125655, RHEA:26160] +xref: EC:5.4.99.31 +xref: RHEA:26160 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0051747 +name: cytosine C-5 DNA demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA." [PMID:10050851] +synonym: "DNA demethylase activity" BROAD [PMID:10050851] +synonym: "DNA methyltransferase activity acting on cytosine C-5" EXACT [] +synonym: "hydrolytic DNA demethylase activity" BROAD [] +is_a: GO:0016787 ! hydrolase activity +is_a: GO:0035514 ! DNA demethylase activity + +[Term] +id: GO:0051748 +name: UTP-monosaccharide-1-phosphate uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide." [EC:2.7.7.64, PMID:15326166] +synonym: "PsUSP" RELATED [EC:2.7.7.64] +synonym: "UDP-monosaccharide diphosphorylase activity" EXACT [] +synonym: "UDP-monosaccharide pyrophosphorylase activity" EXACT [] +synonym: "UDP-sugar pyrophosphorylase activity" RELATED [EC:2.7.7.64] +synonym: "USP" RELATED [EC:2.7.7.64] +xref: EC:2.7.7.64 +xref: MetaCyc:2.7.7.64-RXN +xref: RHEA:13205 +is_a: GO:0070569 ! uridylyltransferase activity + +[Term] +id: GO:0051749 +name: indole acetic acid carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." [PMID:16169896] +synonym: "IAA carboxyl methyltransferase activity" EXACT [] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0051750 +name: delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity +namespace: molecular_function +alt_id: GO:0008416 +def: "Catalysis of the reaction: a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA." [PMID:11278886, PMID:16040662, RHEA:45240] +synonym: "delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity" EXACT [] +synonym: "delta3,5-delta2,4-dienoyl-CoA isomerase activity" EXACT [] +synonym: "delta5-delta2,4-dienoyl-CoA isomerase activity" RELATED [] +xref: EC.5.3.3.21 +xref: RHEA:45240 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0051751 +name: alpha-1,4-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage." [PMID:15772281] +is_a: GO:0000030 ! mannosyltransferase activity + +[Term] +id: GO:0051752 +name: phosphoglucan, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate." [EC:2.7.9.5, PMID:15618411] +synonym: "ATP:phospho-alpha-glucan, water phosphotransferase activity" RELATED [EC:2.7.9.5] +synonym: "OK1" RELATED [EC:2.7.9.5] +synonym: "PWD" RELATED [EC:2.7.9.5] +xref: EC:2.7.9.5 +xref: MetaCyc:2.7.9.5-RXN +is_a: GO:0016301 ! kinase activity +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0051753 +name: mannan synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan." [PMID:14726589] +synonym: "galactomannan beta-1,4-mannosyltransferase activity" NARROW [] +synonym: "mannan beta-1,4-mannosyltransferase activity" EXACT [] +is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity + +[Term] +id: GO:0051754 +name: meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] +synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] +synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] +synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] +is_a: GO:0051177 ! meiotic sister chromatid cohesion +is_a: GO:0070601 ! centromeric sister chromatid cohesion + +[Term] +id: GO:0051755 +name: meiotic sister chromatid arm separation +namespace: biological_process +def: "The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [GOC:ai] +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007127 ! meiosis I +relationship: part_of GO:0051757 ! meiotic sister chromatid separation + +[Term] +id: GO:0051756 +name: meiotic sister chromatid centromere separation +namespace: biological_process +def: "The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] +is_a: GO:0034510 ! centromere separation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation +relationship: part_of GO:0051757 ! meiotic sister chromatid separation + +[Term] +id: GO:0051757 +name: meiotic sister chromatid separation +namespace: biological_process +def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] +synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah] +is_a: GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:0051758 +name: homologous chromosome movement towards spindle pole in meiosis I anaphase +namespace: biological_process +def: "The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase." [GOC:ai] +synonym: "homologous chromosome movement towards spindle pole during meiosis I" RELATED [GOC:dph, GOC:tb] +synonym: "meiosis I, homologous chromosome movement towards spindle pole" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0051759 +name: sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation +namespace: biological_process +def: "The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II." [GOC:ai] +synonym: "meiosis II, sister chromosome movement towards spindle pole" EXACT [] +synonym: "sister chromosome movement towards spindle pole during meiosis II" RELATED [GOC:dph, GOC:tb] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +relationship: part_of GO:0045144 ! meiotic sister chromatid segregation + +[Term] +id: GO:0051760 +name: meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] +synonym: "meiotic sister chromatid cohesion along arms" EXACT [] +synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] +is_a: GO:0051177 ! meiotic sister chromatid cohesion + +[Term] +id: GO:0051761 +name: sesquiterpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +synonym: "sesquiterpene metabolism" EXACT [] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:0051762 +name: sesquiterpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:0051763 +name: sesquiterpene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene." [GOC:ai] +is_a: GO:0046247 ! terpene catabolic process +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:0051764 +name: actin crosslink formation +namespace: biological_process +def: "The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes." [GOC:ai] +comment: See also the molecular function term 'protein binding, bridging ; GO:0030674'. +synonym: "actin bundling" RELATED [] +synonym: "actin crosslinking" EXACT [] +synonym: "bridging actin filaments" NARROW [] +synonym: "formation of actin crosslink" EXACT [] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0051765 +name: inositol tetrakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP." [GOC:ai] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0051766 +name: inositol trisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP." [GOC:ai] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0051767 +name: nitric-oxide synthase biosynthetic process +namespace: biological_process +alt_id: GO:0051768 +def: "The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39, GOC:ai] +synonym: "brain nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] +synonym: "endothelial nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] +synonym: "inducible nitric-oxide synthase biosynthetic process" NARROW [GOC:bf] +synonym: "nitric-oxide synthase (type 2) biosynthesis" NARROW [] +synonym: "nitric-oxide synthase (type 2) biosynthetic process" NARROW [] +synonym: "nitric-oxide synthase (type II) biosynthesis" NARROW [] +synonym: "nitric-oxide synthase (type II) biosynthetic process" NARROW [] +synonym: "nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "nitric-oxide synthase-1 biosynthetic process" NARROW [GOC:bf] +synonym: "nitric-oxide synthase-2 biosynthetic process" NARROW [GOC:bf] +synonym: "nitric-oxide synthase-3 biosynthetic process" NARROW [GOC:bf] +synonym: "NO synthase biosynthesis" EXACT [] +synonym: "NO synthase biosynthetic process" EXACT [] +synonym: "NOS biosynthesis" EXACT [] +synonym: "NOS biosynthetic process" EXACT [] +synonym: "NOS1 biosynthesis" NARROW [GOC:bf] +synonym: "NOS2 biosynthesis" NARROW [GOC:bf] +synonym: "NOS2 synthase biosynthesis" NARROW [] +synonym: "NOS2 synthase biosynthetic process" NARROW [] +synonym: "NOS3 biosynthesis" NARROW [GOC:bf] +is_a: GO:0009059 ! macromolecule biosynthetic process + +[Term] +id: GO:0051769 +name: regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +alt_id: GO:0051772 +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai] +synonym: "regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] +synonym: "regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] +synonym: "regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] +synonym: "regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] +synonym: "regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "regulation of NO synthase biosynthesis" EXACT [] +synonym: "regulation of NO synthase biosynthetic process" EXACT [] +synonym: "regulation of NOS biosynthesis" EXACT [] +synonym: "regulation of NOS biosynthetic process" EXACT [] +synonym: "regulation of NOS2 synthase biosynthesis" NARROW [] +synonym: "regulation of NOS2 synthase biosynthetic process" NARROW [] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051770 +name: positive regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +alt_id: GO:0051773 +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric oxide synthase enzyme." [GOC:ai] +synonym: "activation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "activation of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] +synonym: "positive regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] +synonym: "positive regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] +synonym: "positive regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] +synonym: "positive regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "positive regulation of NO synthase biosynthesis" EXACT [] +synonym: "positive regulation of NO synthase biosynthetic process" EXACT [] +synonym: "positive regulation of NOS biosynthesis" EXACT [] +synonym: "positive regulation of NOS biosynthetic process" EXACT [] +synonym: "positive regulation of NOS2 synthase biosynthesis" NARROW [] +synonym: "positive regulation of NOS2 synthase biosynthetic process" NARROW [] +synonym: "stimulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "stimulation of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "up regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "up regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "up-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "up-regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "upregulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "upregulation of nitric-oxide synthase biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process +relationship: positively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051771 +name: negative regulation of nitric-oxide synthase biosynthetic process +namespace: biological_process +alt_id: GO:0051774 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a nitric-oxide synthase enzyme." [GOC:ai] +synonym: "down regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "down regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "down-regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "down-regulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "downregulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "downregulation of nitric-oxide synthase biosynthetic process" EXACT [] +synonym: "inhibition of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "inhibition of nitric-oxide synthase biosynthetic process" NARROW [] +synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthesis" NARROW [] +synonym: "negative regulation of nitric-oxide synthase (type 2) biosynthetic process" NARROW [] +synonym: "negative regulation of nitric-oxide synthase (type II) biosynthesis" NARROW [] +synonym: "negative regulation of nitric-oxide synthase (type II) biosynthetic process" NARROW [] +synonym: "negative regulation of nitric-oxide synthase 2 biosynthetic process" NARROW [] +synonym: "negative regulation of NO synthase biosynthesis" EXACT [] +synonym: "negative regulation of NO synthase biosynthetic process" EXACT [] +synonym: "negative regulation of NOS biosynthesis" EXACT [] +synonym: "negative regulation of NOS biosynthetic process" EXACT [] +synonym: "negative regulation of NOS2 synthase biosynthesis" NARROW [] +synonym: "negative regulation of NOS2 synthase biosynthetic process" NARROW [] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0051769 ! regulation of nitric-oxide synthase biosynthetic process +relationship: negatively_regulates GO:0051767 ! nitric-oxide synthase biosynthetic process + +[Term] +id: GO:0051775 +name: response to redox state +namespace: biological_process +alt_id: GO:0006980 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] +synonym: "redox signal response" EXACT [] +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0051776 +name: detection of redox state +namespace: biological_process +def: "The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah, PMID:15131240, PMID:16987039] +synonym: "redox sensing" EXACT [] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0051777 +name: ent-kaurenoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-159] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. +synonym: "ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity" RELATED [EC:1.14.13.79] +synonym: "ent-kaurenoic acid oxidase activity" EXACT [] +xref: MetaCyc:1.14.13.79-RXN +xref: RHEA:19241 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051778 +name: ent-7-alpha-hydroxykaurenoate oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-160] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. +xref: MetaCyc:RXN1F-160 +xref: RHEA:22904 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051779 +name: gibberellin 12-aldehyde oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12)." [EC:1.14.13.79, MetaCyc:RXN1F-161] +comment: Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. +synonym: "GA12-aldehyde oxidase activity" EXACT [] +xref: MetaCyc:RXN1F-161 +xref: RHEA:22700 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0051780 +name: behavioral response to nutrient +namespace: biological_process +def: "Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus." [GOC:ai] +synonym: "behavioural response to nutrient" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0007584 ! response to nutrient + +[Term] +id: GO:0051781 +name: positive regulation of cell division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] +synonym: "activation of cell division" NARROW [] +synonym: "stimulation of cell division" NARROW [] +synonym: "up regulation of cell division" EXACT [] +synonym: "up-regulation of cell division" EXACT [] +synonym: "upregulation of cell division" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051302 ! regulation of cell division +relationship: positively_regulates GO:0051301 ! cell division + +[Term] +id: GO:0051782 +name: negative regulation of cell division +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] +synonym: "down regulation of cell division" EXACT [] +synonym: "down-regulation of cell division" EXACT [] +synonym: "downregulation of cell division" EXACT [] +synonym: "inhibition of cell division" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051302 ! regulation of cell division +relationship: negatively_regulates GO:0051301 ! cell division + +[Term] +id: GO:0051783 +name: regulation of nuclear division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051784 +name: negative regulation of nuclear division +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +synonym: "down regulation of nuclear division" EXACT [] +synonym: "down-regulation of nuclear division" EXACT [] +synonym: "downregulation of nuclear division" EXACT [] +synonym: "inhibition of nuclear division" NARROW [] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0051783 ! regulation of nuclear division +relationship: negatively_regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051785 +name: positive regulation of nuclear division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] +synonym: "activation of nuclear division" NARROW [] +synonym: "stimulation of nuclear division" NARROW [] +synonym: "up regulation of nuclear division" EXACT [] +synonym: "up-regulation of nuclear division" EXACT [] +synonym: "upregulation of nuclear division" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0051783 ! regulation of nuclear division +relationship: positively_regulates GO:0000280 ! nuclear division + +[Term] +id: GO:0051786 +name: all-trans-retinol 13,14-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction." [EC:1.3.99.23, RHEA:19193] +synonym: "(13,14)-all-trans-retinol saturase activity" EXACT [] +synonym: "all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity" EXACT [] +synonym: "all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity" EXACT [] +synonym: "retinol saturase activity" RELATED [EC:1.3.99.23] +synonym: "RetSat activity" RELATED [EC:1.3.99.23] +xref: EC:1.3.99.23 +xref: KEGG_REACTION:R07163 +xref: MetaCyc:1.3.99.23-RXN +xref: Reactome:R-HSA-8956427 "RETSAT reduces atROL to at-13,14-dhROL" +xref: RHEA:19193 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0051787 +name: misfolded protein binding +namespace: molecular_function +def: "Binding to a misfolded protein." [GOC:ai] +xref: Reactome:R-HSA-5324632 "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates" +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051788 +name: response to misfolded protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:go_curators] +is_a: GO:0035966 ! response to topologically incorrect protein + +[Term] +id: GO:0051789 +name: obsolete response to protein +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:ai] +comment: This term was made obsolete because more specific terms exist. +synonym: "response to protein" EXACT [] +synonym: "response to protein stimulus" EXACT [GOC:dos] +is_obsolete: true +consider: GO:0006986 +consider: GO:0009725 +consider: GO:0034097 +consider: GO:0051788 +consider: GO:0070848 + +[Term] +id: GO:0051790 +name: short-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6." [Wikipedia:Fatty_acid_metabolism] +synonym: "short chain fatty acid biosynthesis" EXACT [] +synonym: "short chain fatty acid biosynthetic process" EXACT [] +synonym: "short-chain fatty acid anabolism" EXACT [] +synonym: "short-chain fatty acid biosynthesis" EXACT [] +synonym: "short-chain fatty acid formation" EXACT [] +synonym: "short-chain fatty acid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0046459 ! short-chain fatty acid metabolic process + +[Term] +id: GO:0051791 +name: medium-chain fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolisms] +synonym: "medium chain fatty acid metabolic process" EXACT [] +synonym: "medium chain fatty acid metabolism" EXACT [] +synonym: "medium-chain fatty acid metabolism" EXACT [] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0051792 +name: medium-chain fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolism] +synonym: "medium chain fatty acid biosynthesis" EXACT [] +synonym: "medium chain fatty acid biosynthetic process" EXACT [] +synonym: "medium-chain fatty acid anabolism" EXACT [] +synonym: "medium-chain fatty acid biosynthesis" EXACT [] +synonym: "medium-chain fatty acid formation" EXACT [] +synonym: "medium-chain fatty acid synthesis" EXACT [] +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0051791 ! medium-chain fatty acid metabolic process + +[Term] +id: GO:0051793 +name: medium-chain fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12." [Wikipedia:Fatty_acid_metabolism] +synonym: "medium chain fatty acid catabolic process" EXACT [] +synonym: "medium chain fatty acid catabolism" EXACT [] +synonym: "medium-chain fatty acid breakdown" EXACT [] +synonym: "medium-chain fatty acid catabolism" EXACT [] +synonym: "medium-chain fatty acid degradation" EXACT [] +is_a: GO:0009062 ! fatty acid catabolic process +is_a: GO:0051791 ! medium-chain fatty acid metabolic process + +[Term] +id: GO:0051794 +name: regulation of timing of catagen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "regulation of catagen" RELATED [] +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042637 ! catagen + +[Term] +id: GO:0051795 +name: positive regulation of timing of catagen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "activation of catagen" NARROW [] +synonym: "positive regulation of catagen" RELATED [] +synonym: "stimulation of catagen" NARROW [] +synonym: "up regulation of catagen" RELATED [] +synonym: "up-regulation of catagen" RELATED [] +synonym: "upregulation of catagen" RELATED [] +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051794 ! regulation of timing of catagen +relationship: positively_regulates GO:0042637 ! catagen + +[Term] +id: GO:0051796 +name: negative regulation of timing of catagen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "down regulation of catagen" RELATED [] +synonym: "down-regulation of catagen" RELATED [] +synonym: "downregulation of catagen" RELATED [] +synonym: "inhibition of catagen" NARROW [] +synonym: "negative regulation of catagen" RELATED [] +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051794 ! regulation of timing of catagen +relationship: negatively_regulates GO:0042637 ! catagen + +[Term] +id: GO:0051797 +name: regulation of hair follicle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hair follicle development." [GOC:ai] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051798 +name: positive regulation of hair follicle development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hair follicle development." [GOC:ai] +synonym: "activation of hair follicle development" NARROW [] +synonym: "stimulation of hair follicle development" NARROW [] +synonym: "up regulation of hair follicle development" EXACT [] +synonym: "up-regulation of hair follicle development" EXACT [] +synonym: "upregulation of hair follicle development" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0051797 ! regulation of hair follicle development +relationship: positively_regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051799 +name: negative regulation of hair follicle development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development." [GOC:ai] +synonym: "down regulation of hair follicle development" EXACT [] +synonym: "down-regulation of hair follicle development" EXACT [] +synonym: "downregulation of hair follicle development" EXACT [] +synonym: "inhibition of hair follicle development" NARROW [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0051797 ! regulation of hair follicle development +relationship: negatively_regulates GO:0001942 ! hair follicle development + +[Term] +id: GO:0051800 +name: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate." [GOC:bf, PMID:9811831] +synonym: "PTEN activity" BROAD [] +xref: Reactome:R-HSA-1676149 "PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane" +xref: Reactome:R-HSA-1676204 "PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane" +is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity + +[Term] +id: GO:0051801 +name: obsolete cytolysis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction." [GOC:add] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0051802 +name: obsolete regulation of cytolysis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0051803 +name: obsolete negative regulation of cytolysis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "down regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] +synonym: "down-regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] +synonym: "downregulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [] +synonym: "inhibition of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "negative regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0051804 +name: obsolete positive regulation of cytolysis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "activation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation of cytolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "positive regulation of cytolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] +synonym: "stimulation of cytolysis of cells in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "up-regulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +synonym: "upregulation of cytolysis of cells in other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051814 +name: obsolete movement in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism or its progeny spreads from one location to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "movement in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "movement within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051815 +name: obsolete migration in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directional movement of an organism from one place to another within a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "migration in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "migration within other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0051816 +name: obsolete acquisition of nutrients from other organism during symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it represented an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0051817 +name: obsolete modulation of process of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification of morphology or physiology of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "modification of morphology or physiology of other organism involved in symbiotic interaction" RELATED [] +synonym: "modulation of biological process of other organism involved in symbiotic interaction" RELATED [] +synonym: "modulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] +synonym: "regulation of morphology of other organism during symbiotic interaction" NARROW [] +synonym: "regulation of morphology or physiology of other organism during symbiotic interaction" RELATED [] +synonym: "regulation of physiological process in other organism during symbiotic interaction" NARROW [] +synonym: "regulation of physiology of other organism during symbiotic interaction" NARROW [] +is_obsolete: true + +[Term] +id: GO:0051818 +name: obsolete disruption of cells of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "disruption of cells of other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051819 +name: induction by symbiont of tumor or growth in host +namespace: biological_process +alt_id: GO:0044005 +alt_id: GO:0044006 +alt_id: GO:0051820 +def: "The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic." [GOC:pg] +synonym: "induction by symbiont in host of tumor, nodule, or growth" RELATED [] +synonym: "induction by symbiont in host of tumor, nodule, or growth containing transformed cells" RELATED [] +synonym: "induction by symbiont of nodulation, tumor or growth in host" RELATED [] +synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction" RELATED [] +synonym: "induction of tumor, nodule, or growth in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "induction of tumor, nodule, or growth in other organism involved in symbiotic interaction" RELATED [] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0051821 +name: obsolete dissemination or transmission of organism from other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The movement of an organism from a second organism to another place in the environment, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism." [GOC:cc] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont. +synonym: "dissemination or transmission of organism from other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0051822 +name: obsolete dissemination or transmission of organism from other organism by vector involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The movement of an organism from a second organism to another place in the environment by means of a vector, where the two organisms are in a symbiotic interaction. The first organism may also move to a different organism, and the vector organism is often an insect or an animal." [GOC:cc] +comment: This term was obsoleted because it did not represent a specific process, but represented the life cycle of a symbiont. +synonym: "dissemination or transmission of organism from other organism by vector during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051823 +name: regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane." [PMID:11063967, PMID:14976517, PMID:9884123] +synonym: "regulation of synaptic structural plasticity" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization + +[Term] +id: GO:0051826 +name: negative regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity." [GOC:ai] +synonym: "down regulation of synapse structural plasticity" EXACT [] +synonym: "down-regulation of synapse structural plasticity" EXACT [] +synonym: "downregulation of synapse structural plasticity" EXACT [] +synonym: "inhibition of synapse structural plasticity" NARROW [] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051823 ! regulation of synapse structural plasticity + +[Term] +id: GO:0051827 +name: obsolete growth or development on or near surface of other organism during symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development on or near surface of other organism during symbiotic interaction" EXACT [] +is_obsolete: true +consider: GO:0044111 + +[Term] +id: GO:0051831 +name: obsolete growth or development in other organism during symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development in other organism during symbiotic interaction" EXACT [] +synonym: "growth or development within other organism during symbiotic interaction" EXACT [] +synonym: "invasive growth" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051835 +name: positive regulation of synapse structural plasticity +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity." [GOC:ai] +synonym: "activation of synapse structural plasticity" NARROW [] +synonym: "stimulation of synapse structural plasticity" NARROW [] +synonym: "up regulation of synapse structural plasticity" EXACT [] +synonym: "up-regulation of synapse structural plasticity" EXACT [] +synonym: "upregulation of synapse structural plasticity" EXACT [] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051823 ! regulation of synapse structural plasticity + +[Term] +id: GO:0051838 +name: cytolysis by host of symbiont cells +namespace: biological_process +def: "The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +is_a: GO:0051873 ! killing by host of symbiont cells + +[Term] +id: GO:0051839 +name: regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0051709 ! regulation of killing of cells of another organism +relationship: regulates GO:0051838 ! cytolysis by host of symbiont cells + +[Term] +id: GO:0051840 +name: negative regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +synonym: "down regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "down-regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "downregulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "inhibition by host of cytolysis of symbiont cells" NARROW [] +is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells + +[Term] +id: GO:0051841 +name: positive regulation by host of cytolysis of symbiont cells +namespace: biological_process +def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +synonym: "activation by host of cytolysis of symbiont cells" NARROW [] +synonym: "stimulation by host of cytolysis of symbiont cells" NARROW [] +synonym: "up regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "up-regulation by host of cytolysis of symbiont cells" EXACT [] +synonym: "upregulation by host of cytolysis of symbiont cells" EXACT [] +is_a: GO:0051839 ! regulation by host of cytolysis of symbiont cells + +[Term] +id: GO:0051842 +name: obsolete evasion or tolerance of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process, either active or passive, by which an organism avoids the effects of the symbiont organism's immune response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mb] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +synonym: "evasion or tolerance of symbiont immune response" EXACT [] +synonym: "immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051843 +name: obsolete evasion or tolerance of symbiont defense response +namespace: biological_process +def: "OBSOLETE. Any process, either active or passive, by which an organism avoids or tolerates the effects of a symbiont organism's defense response. The symbiont defense response is mounted by the symbiont in response to the presence of the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mah] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "evasion of symbiont defence response" EXACT [] +synonym: "evasion or tolerance of symbiont defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051844 +name: translocation of peptides or proteins into symbiont +namespace: biological_process +def: "The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "transport of peptides or proteins into symbiont" EXACT [] +is_a: GO:0051862 ! translocation of molecules into symbiont + +[Term] +id: GO:0051845 +name: obsolete passive evasion of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any mechanism of immune avoidance that does not directly interfere with the symbiont immune system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "passive evasion of symbiont immune response" EXACT [] +synonym: "passive immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051846 +name: obsolete active evasion of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any mechanism of immune avoidance that directly affects the symbiont immune system, e.g. blocking any stage in symbiont MHC class I and II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active evasion of symbiont immune response" EXACT [] +synonym: "active immune evasion" BROAD [] +is_obsolete: true + +[Term] +id: GO:0051847 +name: obsolete active evasion of symbiont immune response via regulation of symbiont complement system +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, symbiont macrophages, which are eventually destroyed. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active evasion of symbiont immune response via regulation of symbiont complement system" EXACT [] +synonym: "active immune evasion via modulation of symbiont complement system" EXACT [] +synonym: "active immune evasion via regulation of symbiont complement system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051848 +name: obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active evasion of symbiont immune response via regulation of symbiont cytokine network" EXACT [] +synonym: "active immune evasion via modulation of symbiont cytokine network" EXACT [] +synonym: "active immune evasion via regulation of symbiont cytokine network" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051849 +name: obsolete active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation +namespace: biological_process +def: "OBSOLETE. Any mechanism of active immune avoidance which works by regulating the symbiont's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:12439615] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation" EXACT [] +synonym: "active evasion of symbiont immune response via regulation of symbiont antigen processing and presentation pathway" EXACT [] +synonym: "active immune evasion via modulation of symbiont antigen processing and presentation" EXACT [] +synonym: "active immune evasion via modulation of symbiont antigen processing/presentation" EXACT [] +synonym: "active immune evasion via regulation of symbiont antigen processing or presentation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051850 +name: acquisition of nutrients from symbiont +namespace: biological_process +def: "The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +is_a: GO:0051702 ! biological process involved in interaction with symbiont + +[Term] +id: GO:0051851 +name: modulation by host of symbiont process +namespace: biological_process +def: "The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "modification by host of symbiont morphology or physiology" RELATED [] +is_a: GO:0051702 ! biological process involved in interaction with symbiont + +[Term] +id: GO:0051853 +name: obsolete induction in symbiont of tumor, nodule, or growth +namespace: biological_process +def: "OBSOLETE. The process by which an associated organism causes the formation of an abnormal mass of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "induction in symbiont of tumor, nodule, or growth" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051854 +name: obsolete induction in symbiont of tumor, nodule, or growth containing transformed cells +namespace: biological_process +def: "OBSOLETE. The process by which an organism causes the formation in its symbiont organism of an abnormal growth whose cells have been transformed and continue to exist in the absence of the first organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "induction in symbiont of tumor, nodule, or growth containing transformed cells" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051857 +name: obsolete growth or development of organism on or near symbiont surface +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "growth or development of organism during interaction with symbiont" EXACT [] +synonym: "growth or development of organism on or near symbiont surface" EXACT [] +is_obsolete: true +consider: GO:0032502 + +[Term] +id: GO:0051858 +name: obsolete avoidance of symbiont defenses +namespace: biological_process +def: "OBSOLETE. Any process, either constitutive or induced, by which an organism evades, minimizes, or suppresses the effects of its symbiont organism's defense(s). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. +is_obsolete: true + +[Term] +id: GO:0051859 +name: obsolete suppression of symbiont defenses +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont defense(s) by active mechanisms that normally result in the shutting down of a symbiont pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. +is_obsolete: true + +[Term] +id: GO:0051860 +name: obsolete evasion or tolerance of symbiont defenses +namespace: biological_process +def: "OBSOLETE. The process, either active or passive, by which an organism evades or tolerates the effects of the defense(s) or defense molecules of a symbiont organism. Symbiont defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. +is_obsolete: true + +[Term] +id: GO:0051861 +name: glycolipid binding +namespace: molecular_function +def: "Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." [PMID:19635802] +is_a: GO:0008289 ! lipid binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0051862 +name: translocation of molecules into symbiont +namespace: biological_process +def: "The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +synonym: "transport of molecules into symbiont" EXACT [] +is_a: GO:0051702 ! biological process involved in interaction with symbiont + +[Term] +id: GO:0051863 +name: obsolete translocation of DNA into symbiont +namespace: biological_process +def: "OBSOLETE. The directed movement of DNA from an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: This term was made obsolete because it does not represent a real process that exists in nature. +synonym: "translocation of DNA into symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0051864 +name: histone H3-methyl-lysine-36 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16362057] +synonym: "[histone-H3]-lysine-36 demethylase activity" EXACT [] +synonym: "histone demethylase activity (H3-K36 specific)" EXACT [] +synonym: "histone H3-lysine-36 demethylase activity" RELATED [] +synonym: "histone H3K36 demethylase activity" RELATED [] +synonym: "histone-lysine (H3-K36) demethylase activity" RELATED [] +synonym: "histone-lysine demethylase activity (H3-K36 specific)" EXACT [] +synonym: "histone-lysine(H3-K36) demethylase activity" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0051865 +name: protein autoubiquitination +namespace: biological_process +def: "The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink." [GOC:ai] +synonym: "protein auto-ubiquitination" EXACT [] +synonym: "protein auto-ubiquitinylation" EXACT [] +synonym: "protein autoubiquitinylation" EXACT [] +synonym: "protein self-ubiquitination" EXACT [] +synonym: "protein self-ubiquitinylation" EXACT [] +is_a: GO:0016567 ! protein ubiquitination + +[Term] +id: GO:0051866 +name: general adaptation syndrome +namespace: biological_process +alt_id: GO:0051868 +def: "General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses." [PMID:14847556, Wikipedia:General_adaptation_syndrome] +synonym: "general adaptation syndrome, physiological process" EXACT [] +synonym: "general adaptation syndrome, physiological response" EXACT [] +synonym: "physiological process during general adaptation syndrome" EXACT [] +synonym: "physiological response during general adaptation syndrome" EXACT [] +is_a: GO:0033555 ! multicellular organismal response to stress + +[Term] +id: GO:0051867 +name: general adaptation syndrome, behavioral process +namespace: biological_process +def: "The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus." [GOC:ai] +synonym: "behavioral process during general adaptation syndrome" EXACT [] +synonym: "behavioral response during general adaptation syndrome" EXACT [] +synonym: "behavioural process during general adaptation syndrome" EXACT [] +synonym: "behavioural response during general adaptation syndrome" EXACT [] +synonym: "general adaptation syndrome, behavioral response" EXACT [] +synonym: "general adaptation syndrome, behavioural process" EXACT [] +synonym: "general adaptation syndrome, behavioural response" EXACT [] +is_a: GO:0007610 ! behavior +relationship: part_of GO:0051866 ! general adaptation syndrome + +[Term] +id: GO:0051870 +name: methotrexate binding +namespace: molecular_function +def: "Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA." [GOC:nln] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0033218 ! amide binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0051871 +name: dihydrofolic acid binding +namespace: molecular_function +def: "Binding to dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms." [ISBN:0721662544] +synonym: "DHF binding" RELATED [] +synonym: "dihydrofolate binding" RELATED [] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0072341 ! modified amino acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0051872 +name: sphingosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ai] +synonym: "(4E)-sphing-4-enine catabolic process" EXACT [] +synonym: "(4E)-sphing-4-enine catabolism" EXACT [] +synonym: "sphing-4-enine catabolic process" EXACT [] +synonym: "sphing-4-enine catabolism" EXACT [] +is_a: GO:0006670 ! sphingosine metabolic process +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0046521 ! sphingoid catabolic process + +[Term] +id: GO:0051873 +name: killing by host of symbiont cells +namespace: biological_process +alt_id: GO:0051852 +def: "Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add] +synonym: "disruption by host of symbiont cells" BROAD [] +is_a: GO:0051702 ! biological process involved in interaction with symbiont +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0051874 +name: sphinganine-1-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] +synonym: "dihydrosphingosine-1-phosphate catabolic process" EXACT [] +synonym: "dihydrosphingosine-1-phosphate catabolism" EXACT [] +is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process + +[Term] +id: GO:0051875 +name: pigment granule localization +namespace: biological_process +def: "Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] +synonym: "pigment granule localisation" EXACT [GOC:mah] +is_a: GO:0051648 ! vesicle localization +relationship: part_of GO:0033059 ! cellular pigmentation + +[Term] +id: GO:0051876 +name: pigment granule dispersal +namespace: biological_process +def: "The directed movement of pigment granules within a cell towards the cell periphery." [GOC:mh] +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051877 +name: pigment granule aggregation in cell center +namespace: biological_process +def: "The directed movement of dispersed pigment granules towards the center of the cell." [GOC:mh] +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051878 +name: lateral element assembly +namespace: biological_process +def: "The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements." [PMID:11463847] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007130 ! synaptonemal complex assembly + +[Term] +id: GO:0051879 +name: Hsp90 protein binding +namespace: molecular_function +def: "Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size." [GOC:ai] +synonym: "Hsp90 binding" EXACT [] +synonym: "Hsp90 class protein binding" EXACT [] +is_a: GO:0031072 ! heat shock protein binding + +[Term] +id: GO:0051880 +name: G-quadruplex DNA binding +namespace: molecular_function +def: "Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome." [PMID:16142245, PMID:9512530] +synonym: "G quadruplex DNA binding" EXACT [GOC:mah] +synonym: "G quartet binding" BROAD [GOC:mah] +synonym: "G quartet DNA binding" EXACT [GOC:mah] +synonym: "G-DNA binding" EXACT [] +synonym: "G-quartet binding" BROAD [GOC:mah] +synonym: "G-quartet DNA binding" EXACT [GOC:mah] +synonym: "quadruplex DNA binding" EXACT [] +synonym: "tetraplex DNA binding" EXACT [] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0051881 +name: regulation of mitochondrial membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:ai] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0051882 +name: mitochondrial depolarization +namespace: biological_process +def: "The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level." [Wikipedia:Depolarization, Wikipedia:Mitochondrion] +synonym: "mitochondria depolarization" EXACT [] +synonym: "mitochondrial depolarisation" EXACT [] +synonym: "mitochondrial membrane depolarization" EXACT [] +synonym: "mitochondrion depolarization" EXACT [] +is_a: GO:0051881 ! regulation of mitochondrial membrane potential +is_a: GO:0051899 ! membrane depolarization + +[Term] +id: GO:0051883 +name: obsolete killing of cells in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction." [GOC:add] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "killing of cells in other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0051884 +name: regulation of timing of anagen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "regulation of anagen" RELATED [] +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042640 ! anagen + +[Term] +id: GO:0051885 +name: positive regulation of timing of anagen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "activation of anagen" NARROW [] +synonym: "positive regulation of anagen" RELATED [] +synonym: "stimulation of anagen" NARROW [] +synonym: "up regulation of anagen" RELATED [] +synonym: "up-regulation of anagen" RELATED [] +synonym: "upregulation of anagen" RELATED [] +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051884 ! regulation of timing of anagen +relationship: positively_regulates GO:0042640 ! anagen + +[Term] +id: GO:0051886 +name: negative regulation of timing of anagen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "down regulation of anagen" RELATED [] +synonym: "down-regulation of anagen" RELATED [] +synonym: "downregulation of anagen" RELATED [] +synonym: "inhibition of anagen" NARROW [] +synonym: "negative regulation of anagen" RELATED [] +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051884 ! regulation of timing of anagen +relationship: negatively_regulates GO:0042640 ! anagen + +[Term] +id: GO:0051887 +name: regulation of timing of exogen +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "regulation of exogen" RELATED [] +is_a: GO:0048819 ! regulation of hair follicle maturation +relationship: regulates GO:0042638 ! exogen + +[Term] +id: GO:0051888 +name: positive regulation of timing of exogen +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "activation of exogen" NARROW [] +synonym: "positive regulation of exogen" RELATED [] +synonym: "stimulation of exogen" NARROW [] +synonym: "up regulation of exogen" RELATED [] +synonym: "up-regulation of exogen" RELATED [] +synonym: "upregulation of exogen" RELATED [] +is_a: GO:0048818 ! positive regulation of hair follicle maturation +is_a: GO:0051887 ! regulation of timing of exogen +relationship: positively_regulates GO:0042638 ! exogen + +[Term] +id: GO:0051889 +name: negative regulation of timing of exogen +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle." [GOC:ai, GOC:pr] +synonym: "down regulation of exogen" RELATED [] +synonym: "down-regulation of exogen" RELATED [] +synonym: "downregulation of exogen" RELATED [] +synonym: "inhibition of exogen" NARROW [] +synonym: "negative regulation of exogen" RELATED [] +is_a: GO:0048817 ! negative regulation of hair follicle maturation +is_a: GO:0051887 ! regulation of timing of exogen +relationship: negatively_regulates GO:0042638 ! exogen + +[Term] +id: GO:0051890 +name: regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] +is_a: GO:1905207 ! regulation of cardiocyte differentiation +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051891 +name: positive regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] +synonym: "activation of cardioblast differentiation" NARROW [] +synonym: "stimulation of cardioblast differentiation" NARROW [] +synonym: "up regulation of cardioblast differentiation" EXACT [] +synonym: "up-regulation of cardioblast differentiation" EXACT [] +synonym: "upregulation of cardioblast differentiation" EXACT [] +is_a: GO:0051890 ! regulation of cardioblast differentiation +is_a: GO:1905209 ! positive regulation of cardiocyte differentiation +is_a: GO:2000738 ! positive regulation of stem cell differentiation +relationship: positively_regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051892 +name: negative regulation of cardioblast differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:ai] +synonym: "down regulation of cardioblast differentiation" EXACT [] +synonym: "down-regulation of cardioblast differentiation" EXACT [] +synonym: "downregulation of cardioblast differentiation" EXACT [] +synonym: "inhibition of cardioblast differentiation" NARROW [] +is_a: GO:0051890 ! regulation of cardioblast differentiation +is_a: GO:1905208 ! negative regulation of cardiocyte differentiation +is_a: GO:2000737 ! negative regulation of stem cell differentiation +relationship: negatively_regulates GO:0010002 ! cardioblast differentiation + +[Term] +id: GO:0051893 +name: regulation of focal adhesion assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions." [GOC:ai] +synonym: "regulation of adhesion plaque assembly" RELATED [] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +is_a: GO:0090109 ! regulation of cell-substrate junction assembly +relationship: regulates GO:0048041 ! focal adhesion assembly + +[Term] +id: GO:0051894 +name: positive regulation of focal adhesion assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] +synonym: "activation of focal adhesion formation" NARROW [] +synonym: "stimulation of focal adhesion formation" NARROW [] +synonym: "up regulation of focal adhesion formation" EXACT [] +synonym: "up-regulation of focal adhesion formation" EXACT [] +synonym: "upregulation of focal adhesion formation" EXACT [] +is_a: GO:0001954 ! positive regulation of cell-matrix adhesion +is_a: GO:0051893 ! regulation of focal adhesion assembly +is_a: GO:0150117 ! positive regulation of cell-substrate junction organization +is_a: GO:1901890 ! positive regulation of cell junction assembly +relationship: positively_regulates GO:0048041 ! focal adhesion assembly + +[Term] +id: GO:0051895 +name: negative regulation of focal adhesion assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions." [GOC:ai] +synonym: "down regulation of focal adhesion formation" EXACT [] +synonym: "down-regulation of focal adhesion formation" EXACT [] +synonym: "downregulation of focal adhesion formation" EXACT [] +synonym: "inhibition of focal adhesion formation" NARROW [] +is_a: GO:0001953 ! negative regulation of cell-matrix adhesion +is_a: GO:0051893 ! regulation of focal adhesion assembly +is_a: GO:0150118 ! negative regulation of cell-substrate junction organization +is_a: GO:1901889 ! negative regulation of cell junction assembly +relationship: negatively_regulates GO:0048041 ! focal adhesion assembly + +[Term] +id: GO:0051896 +name: regulation of protein kinase B signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "regulation of AKT signaling cascade" RELATED [] +synonym: "regulation of AKT signalling cascade" RELATED [] +synonym: "regulation of PKB signaling cascade" RELATED [] +synonym: "regulation of PKB signalling cascade" RELATED [] +synonym: "regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of protein kinase B signalling cascade" RELATED [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0043491 ! protein kinase B signaling + +[Term] +id: GO:0051897 +name: positive regulation of protein kinase B signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "activation of protein kinase B signaling cascade" NARROW [] +synonym: "positive regulation of AKT signaling cascade" RELATED [] +synonym: "positive regulation of AKT signalling cascade" EXACT [] +synonym: "positive regulation of PKB signaling cascade" EXACT [] +synonym: "positive regulation of PKB signalling cascade" RELATED [] +synonym: "positive regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of protein kinase B signalling cascade" RELATED [] +synonym: "stimulation of protein kinase B signaling cascade" NARROW [] +synonym: "up regulation of protein kinase B signaling cascade" RELATED [] +synonym: "up-regulation of protein kinase B signaling cascade" RELATED [] +synonym: "upregulation of protein kinase B signaling cascade" RELATED [] +is_a: GO:0051896 ! regulation of protein kinase B signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0043491 ! protein kinase B signaling + +[Term] +id: GO:0051898 +name: negative regulation of protein kinase B signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B." [GOC:ai] +synonym: "down regulation of protein kinase B signaling cascade" RELATED [] +synonym: "down-regulation of protein kinase B signaling cascade" RELATED [] +synonym: "downregulation of protein kinase B signaling cascade" RELATED [] +synonym: "inhibition of protein kinase B signaling cascade" NARROW [] +synonym: "negative regulation of AKT signaling cascade" RELATED [] +synonym: "negative regulation of AKT signalling cascade" EXACT [] +synonym: "negative regulation of PKB signaling cascade" EXACT [] +synonym: "negative regulation of PKB signalling cascade" RELATED [] +synonym: "negative regulation of protein kinase B signaling cascade" RELATED [GOC:signaling] +synonym: "negative regulation of protein kinase B signalling cascade" RELATED [] +is_a: GO:0051896 ! regulation of protein kinase B signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0043491 ! protein kinase B signaling + +[Term] +id: GO:0051899 +name: membrane depolarization +namespace: biological_process +def: "The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dh, Wikipedia:Depolarization] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0051900 +name: regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +is_a: GO:0003254 ! regulation of membrane depolarization +is_a: GO:0051881 ! regulation of mitochondrial membrane potential +relationship: regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051901 +name: positive regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +synonym: "activation of mitochondrial depolarization" NARROW [] +synonym: "stimulation of mitochondrial depolarization" NARROW [] +synonym: "up regulation of mitochondrial depolarization" EXACT [] +synonym: "up-regulation of mitochondrial depolarization" EXACT [] +synonym: "upregulation of mitochondrial depolarization" EXACT [] +is_a: GO:0051900 ! regulation of mitochondrial depolarization +is_a: GO:1904181 ! positive regulation of membrane depolarization +relationship: positively_regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051902 +name: negative regulation of mitochondrial depolarization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive." [GOC:ai] +synonym: "down regulation of mitochondrial depolarization" EXACT [] +synonym: "down-regulation of mitochondrial depolarization" EXACT [] +synonym: "downregulation of mitochondrial depolarization" EXACT [] +synonym: "inhibition of mitochondrial depolarization" NARROW [] +is_a: GO:0051900 ! regulation of mitochondrial depolarization +is_a: GO:1904180 ! negative regulation of membrane depolarization +relationship: negatively_regulates GO:0051882 ! mitochondrial depolarization + +[Term] +id: GO:0051903 +name: S-(hydroxymethyl)glutathione dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+." [EC:1.1.1.284] +synonym: "ADH3 activity" NARROW [EC:1.1.1.284] +synonym: "chi-ADH activity" NARROW [EC:1.1.1.284] +synonym: "class III alcohol dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "FDH activity" RELATED [EC:1.1.1.284] +synonym: "formic dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "GD-FALDH activity" RELATED [EC:1.1.1.284] +synonym: "glutathione-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "GS-FDH activity" RELATED [EC:1.1.1.284] +synonym: "NAD- and glutathione-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "NAD-dependent formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "NAD-linked formaldehyde dehydrogenase activity" RELATED [EC:1.1.1.284] +synonym: "S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.284] +xref: EC:1.1.1.284 +xref: KEGG_REACTION:R06983 +xref: KEGG_REACTION:R07140 +xref: MetaCyc:RXN-2962 +xref: Reactome:R-HSA-5692237 "ADH5 oxidises S-HMGSH to S-FGSH" +xref: UM-BBD_reactionID:r1146 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0051904 +name: pigment granule transport +namespace: biological_process +def: "The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "pigment granule translocation" EXACT [] +is_a: GO:0006810 ! transport +is_a: GO:0051875 ! pigment granule localization +is_a: GO:0051905 ! establishment of pigment granule localization + +[Term] +id: GO:0051905 +name: establishment of pigment granule localization +namespace: biological_process +def: "The directed movement of a pigment granule to a specific location." [GOC:ai] +synonym: "establishment of pigment granule localisation" EXACT [GOC:mah] +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0051875 ! pigment granule localization + +[Term] +id: GO:0051906 +name: maintenance of pigment granule location +namespace: biological_process +def: "Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of pigment granule localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051655 ! maintenance of vesicle location +relationship: part_of GO:0051875 ! pigment granule localization + +[Term] +id: GO:0051907 +name: S-(hydroxymethyl)glutathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione." [EC:4.4.1.22, RHEA:22488] +synonym: "Gfa" RELATED [EC:4.4.1.22] +synonym: "glutathione-dependent formaldehyde-activating enzyme activity" EXACT [] +synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)" RELATED [EC:4.4.1.22] +synonym: "S-(hydroxymethyl)glutathione formaldehyde-lyase activity" RELATED [EC:4.4.1.22] +xref: EC:4.4.1.22 +xref: KEGG_REACTION:R06982 +xref: MetaCyc:RXN-2961 +xref: RHEA:22488 +xref: UM-BBD_reactionID:r1145 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0051908 +name: double-stranded DNA 5'-3' exodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule." [GOC:ai] +synonym: "double-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] +is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity +is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity + +[Term] +id: GO:0051909 +name: acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate +namespace: molecular_function +def: "Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O." [MetaCyc:ACETYLENECARBOXYLATE-HYDRATASE-RXN] +synonym: "3-hydroxypropenoate dehydratase activity" EXACT [] +synonym: "acetylenecarboxylate hydratase activity" BROAD [] +synonym: "acetylenemonocarboxylate hydratase activity" BROAD [] +synonym: "alkynoate hydratase activity" BROAD [] +xref: EC:4.2.1.27 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0051911 +name: Methanosarcina-phenazine hydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine." [EC:1.12.98.3] +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] +synonym: "hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity" RELATED [EC:1.12.98.3] +synonym: "methanophenazine hydrogenase activity" EXACT [] +synonym: "methylviologen-reducing hydrogenase activity" EXACT [] +xref: EC:1.12.98.3 +xref: MetaCyc:RXN-7733 +xref: RHEA:24436 +is_a: GO:0046995 ! oxidoreductase activity, acting on hydrogen as donor, with other known acceptors + +[Term] +id: GO:0051912 +name: CoB--CoM heterodisulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine." [RHEA:18085] +synonym: "CoB-CoM heterodisulfide reductase activity" EXACT [] +synonym: "coenzyme B--coenzyme M heterodisulfide reductase activity" EXACT [] +synonym: "coenzyme B:coenzyme M:methanophenazine oxidoreductase activity" RELATED [EC:1.8.98.1] +synonym: "coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity" RELATED [] +synonym: "heterodisulfide reductase activity" BROAD [] +synonym: "soluble heterodisulfide reductase activity" RELATED [EC:1.8.98.1] +xref: EC:1.8.98.1 +xref: MetaCyc:1.8.98.1-RXN +xref: RHEA:18085 +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0051913 +name: regulation of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "regulation of synaptic plasticity by drug" NARROW [] +is_a: GO:0048167 ! regulation of synaptic plasticity +relationship: part_of GO:0042221 ! response to chemical + +[Term] +id: GO:0051914 +name: positive regulation of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "activation of synaptic plasticity by chemical substance" NARROW [] +synonym: "positive regulation of synaptic plasticity by drug" NARROW [] +synonym: "stimulation of synaptic plasticity by chemical substance" NARROW [] +synonym: "up regulation of synaptic plasticity by chemical substance" EXACT [] +synonym: "up-regulation of synaptic plasticity by chemical substance" EXACT [] +synonym: "upregulation of synaptic plasticity by chemical substance" EXACT [] +is_a: GO:0031915 ! positive regulation of synaptic plasticity +is_a: GO:0051913 ! regulation of synaptic plasticity by chemical substance + +[Term] +id: GO:0051915 +name: induction of synaptic plasticity by chemical substance +namespace: biological_process +def: "The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require." [GOC:ai] +synonym: "activation of synaptic plasticity by chemical substance" EXACT [] +synonym: "activation of synaptic plasticity by drug" NARROW [] +synonym: "induction of synaptic plasticity by drug" NARROW [] +is_a: GO:0051914 ! positive regulation of synaptic plasticity by chemical substance + +[Term] +id: GO:0051916 +name: granulocyte colony-stimulating factor binding +namespace: molecular_function +def: "Binding to granulocyte colony-stimulating factor, G-CSF." [GOC:ai] +synonym: "G-CSF binding" EXACT [] +synonym: "granulocyte colony stimulating factor binding" EXACT [] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0051917 +name: regulation of fibrinolysis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +is_a: GO:0030193 ! regulation of blood coagulation +relationship: regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051918 +name: negative regulation of fibrinolysis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +synonym: "down regulation of fibrinolysis" EXACT [] +synonym: "down-regulation of fibrinolysis" EXACT [] +synonym: "downregulation of fibrinolysis" EXACT [] +synonym: "inhibition of fibrinolysis" NARROW [] +is_a: GO:0030194 ! positive regulation of blood coagulation +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0051917 ! regulation of fibrinolysis +relationship: negatively_regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051919 +name: positive regulation of fibrinolysis +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots." [GOC:ai] +synonym: "activation of fibrinolysis" NARROW [] +synonym: "stimulation of fibrinolysis" NARROW [] +synonym: "up regulation of fibrinolysis" EXACT [] +synonym: "up-regulation of fibrinolysis" EXACT [] +synonym: "upregulation of fibrinolysis" EXACT [] +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0051917 ! regulation of fibrinolysis +relationship: positively_regulates GO:0042730 ! fibrinolysis + +[Term] +id: GO:0051920 +name: peroxiredoxin activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15, RHEA:10008] +comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism. +synonym: "AhpC activity" NARROW [] +synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] +synonym: "PRDX activity" EXACT [] +synonym: "Prx activity" EXACT [] +synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" RELATED [EC:1.11.1.15] +xref: EC:1.11.1.24 +xref: MetaCyc:1.11.1.15-RXN +xref: Reactome:R-HSA-1222431 "Peroxynitrite is reduced to nitrite by AhpC" +xref: Reactome:R-HSA-1222755 "Peroxynitrite is reduced to nitrite by Tpx" +xref: Reactome:R-HSA-1500804 "Peroxynitrite is reduced by AhpE" +xref: RHEA:10008 +is_a: GO:0016209 ! antioxidant activity +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0051921 +name: adenosylcobyric acid synthase (glutamine-hydrolyzing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate." [EC:6.3.5.10, RHEA:23256] +synonym: "5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity" EXACT [] +synonym: "adenosylcobyric acid synthase (glutamine-hydrolysing) activity" EXACT [] +synonym: "adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)" RELATED [EC:6.3.5.10] +synonym: "Ado-cobyric acid synthase [glutamine hydrolyzing] activity" EXACT [] +synonym: "CobQ activity" BROAD [] +synonym: "cobyric acid synthase activity" RELATED [] +xref: EC:6.3.5.10 +xref: KEGG_REACTION:R05225 +xref: MetaCyc:R345-RXN +xref: RHEA:23256 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0051922 +name: cholesterol sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate." [PMID:12730293] +xref: EC:2.8.2.- +is_a: GO:0004027 ! alcohol sulfotransferase activity + +[Term] +id: GO:0051923 +name: sulfation +namespace: biological_process +def: "The addition of a sulfate group to a molecule." [Wikipedia:Sulfation] +synonym: "phase II metabolism" BROAD [PMID:20056724] +synonym: "sulfonation" EXACT [] +synonym: "sulfur addition" EXACT [] +synonym: "sulphation" EXACT [] +synonym: "sulphur addition" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0051924 +name: regulation of calcium ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "regulation of calcium transport" EXACT [] +is_a: GO:0010959 ! regulation of metal ion transport +relationship: regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051925 +name: obsolete regulation of calcium ion transport via voltage-gated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] +synonym: "regulation of calcium transport via voltage-gated calcium channel" EXACT [] +is_obsolete: true +consider: GO:0005245 + +[Term] +id: GO:0051926 +name: negative regulation of calcium ion transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of calcium ion transport" EXACT [] +synonym: "down-regulation of calcium ion transport" EXACT [] +synonym: "downregulation of calcium ion transport" EXACT [] +synonym: "inhibition of calcium ion transport" NARROW [] +synonym: "negative regulation of calcium transport" EXACT [] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: negatively_regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051927 +name: obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a voltage-gated calcium channel." [GOC:ai] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "down regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "down-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "downregulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "inhibition of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "negative regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] +synonym: "negative regulation of calcium transport via voltage gated calcium channel" RELATED [] +is_obsolete: true +consider: GO:0005245 + +[Term] +id: GO:0051928 +name: positive regulation of calcium ion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of calcium ion transport" NARROW [] +synonym: "positive regulation of calcium transport" EXACT [] +synonym: "stimulation of calcium ion transport" NARROW [] +synonym: "up regulation of calcium ion transport" EXACT [] +synonym: "up-regulation of calcium ion transport" EXACT [] +synonym: "upregulation of calcium ion transport" EXACT [] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: positively_regulates GO:0006816 ! calcium ion transport + +[Term] +id: GO:0051929 +name: obsolete positive regulation of calcium ion transport via voltage-gated calcium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via the activity of voltage-gated calcium channels." [GOC:ai] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "activation of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "positive regulation of calcium ion transport via voltage-gated calcium channel activity" EXACT [] +synonym: "positive regulation of calcium transport via voltage gated calcium channel" EXACT [] +synonym: "stimulation of calcium ion transport via voltage gated calcium channel" NARROW [] +synonym: "up regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "up-regulation of calcium ion transport via voltage gated calcium channel" EXACT [] +synonym: "upregulation of calcium ion transport via voltage gated calcium channel" EXACT [] +is_obsolete: true +consider: GO:0005245 + +[Term] +id: GO:0051930 +name: regulation of sensory perception of pain +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0051931 ! regulation of sensory perception +relationship: regulates GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0051931 +name: regulation of sensory perception +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal." [GOC:ai] +is_a: GO:0031644 ! regulation of nervous system process +relationship: regulates GO:0007600 ! sensory perception + +[Term] +id: GO:0051932 +name: synaptic transmission, GABAergic +namespace: biological_process +def: "The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, ISBN:0126603030] +synonym: "GABAergic synaptic transmission" EXACT [] +synonym: "synaptic transmission, GABA mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid mediated" EXACT [] +synonym: "synaptic transmission, gamma-aminobutyric acid-ergic" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0051933 +name: amino acid neurotransmitter reuptake +namespace: biological_process +def: "The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "amino acid neurotransmitter import into glial cell" NARROW [] +synonym: "amino acid neurotransmitter import into neuron" NARROW [] +synonym: "amino acid neurotransmitter recycling" BROAD [] +synonym: "amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +is_a: GO:0043090 ! amino acid import +is_a: GO:0098810 ! neurotransmitter reuptake + +[Term] +id: GO:0051934 +name: catecholamine uptake involved in synaptic transmission +namespace: biological_process +def: "The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "catecholamine neurotransmitter import into glial cell" NARROW [] +synonym: "catecholamine neurotransmitter import into neuron" NARROW [] +synonym: "catecholamine neurotransmitter recycling" BROAD [] +synonym: "catecholamine neurotransmitter reuptake" EXACT [] +synonym: "catecholamine reuptake during transmission of nerve impulse" RELATED [] +synonym: "catecholamine uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +is_a: GO:0090493 ! catecholamine uptake +is_a: GO:0098810 ! neurotransmitter reuptake + +[Term] +id: GO:0051935 +name: glutamate reuptake +namespace: biological_process +def: "The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387, Wikipedia:Glutamate_transporter] +synonym: "glutamate import into glial cell" NARROW [] +synonym: "glutamate import into neuron" NARROW [] +synonym: "glutamate recycling" BROAD [] +synonym: "glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "L-glutamate reuptake" EXACT [] +synonym: "L-glutamate uptake during transmission of nerve impulse" RELATED [] +synonym: "L-glutamate uptake involved in synaptic transmission" EXACT [] +is_a: GO:0051933 ! amino acid neurotransmitter reuptake +is_a: GO:0098712 ! L-glutamate import across plasma membrane + +[Term] +id: GO:0051936 +name: gamma-aminobutyric acid reuptake +namespace: biological_process +def: "The uptake of gamma-aminobutyric acid (GABA, 4-aminobutyrate) by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +synonym: "GABA import into glial cell" NARROW [] +synonym: "GABA import into neuron" NARROW [] +synonym: "GABA recycling" BROAD [] +synonym: "GABA reuptake" EXACT [] +synonym: "gamma-aminobutyric acid import into glial cell" NARROW [] +synonym: "gamma-aminobutyric acid import into neuron" NARROW [] +synonym: "gamma-aminobutyric acid recycling" BROAD [] +synonym: "gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "gamma-aminobutyric acid uptake involved in synaptic transmission" EXACT [] +is_a: GO:0015812 ! gamma-aminobutyric acid transport +is_a: GO:0051933 ! amino acid neurotransmitter reuptake + +[Term] +id: GO:0051937 +name: catecholamine transport +namespace: biological_process +def: "The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, ISBN:0198506732] +is_a: GO:0015844 ! monoamine transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:0051938 +name: L-glutamate import +namespace: biological_process +def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] +synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0051939 +name: gamma-aminobutyric acid import +namespace: biological_process +def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a cell or organelle." [GOC:ai] +synonym: "4-aminobutyrate import" EXACT [] +synonym: "GABA import" EXACT [] +synonym: "gamma-aminobutyrate import" EXACT [] +synonym: "gamma-aminobutyric acid uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0015812 ! gamma-aminobutyric acid transport +is_a: GO:0043090 ! amino acid import + +[Term] +id: GO:0051940 +name: regulation of catecholamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "regulation of catecholamine neurotransmitter uptake" EXACT [] +synonym: "regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission + +[Term] +id: GO:0051941 +name: regulation of amino acid uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "regulation of amino acid neurotransmitter uptake" EXACT [] +synonym: "regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0051933 ! amino acid neurotransmitter reuptake + +[Term] +id: GO:0051942 +name: negative regulation of amino acid uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "down-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "downregulation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "inhibition of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "negative regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "negative regulation of amino acid neurotransmitter uptake" EXACT [] +synonym: "negative regulation of amino acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051956 ! negative regulation of amino acid transport +relationship: negatively_regulates GO:0051933 ! amino acid neurotransmitter reuptake + +[Term] +id: GO:0051943 +name: positive regulation of amino acid uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acid neurotransmitters into a neuron or glial cell." [GOC:ai] +synonym: "activation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "positive regulation of amino acid neurotransmitter reuptake" EXACT [] +synonym: "positive regulation of amino acid neurotransmitter uptake" EXACT [] +synonym: "stimulation of amino acid uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "up-regulation of amino acid uptake during transmission of nerve impulse" RELATED [] +synonym: "upregulation of amino acid uptake during transmission of nerve impulse" RELATED [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051957 ! positive regulation of amino acid transport +relationship: positively_regulates GO:0051933 ! amino acid neurotransmitter reuptake + +[Term] +id: GO:0051944 +name: positive regulation of catecholamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] +synonym: "activation of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "positive regulation of catecholamine neurotransmitter uptake" EXACT [] +synonym: "positive regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] +synonym: "stimulation of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission +is_a: GO:0051954 ! positive regulation of amine transport +relationship: positively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission + +[Term] +id: GO:0051945 +name: negative regulation of catecholamine uptake involved in synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell." [GOC:ai, GOC:dph, GOC:tb] +synonym: "down regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of catecholamine uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of catecholamine uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of catecholamine neurotransmitter reuptake" EXACT [] +synonym: "negative regulation of catecholamine neurotransmitter uptake" EXACT [] +synonym: "negative regulation of catecholamine uptake during transmission of nerve impulse" BROAD [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051940 ! regulation of catecholamine uptake involved in synaptic transmission +is_a: GO:0051953 ! negative regulation of amine transport +relationship: negatively_regulates GO:0051934 ! catecholamine uptake involved in synaptic transmission + +[Term] +id: GO:0051946 +name: regulation of glutamate uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "regulation of glutamate reuptake" EXACT [] +synonym: "regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph] +synonym: "regulation of L-glutamate reuptake" EXACT [] +synonym: "regulation of L-glutamate uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane +is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission +relationship: regulates GO:0051935 ! glutamate reuptake + +[Term] +id: GO:0051947 +name: regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "regulation of GABA reuptake" EXACT [] +synonym: "regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "regulation of gamma-aminobutyric acid reuptake" EXACT [] +synonym: "regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051941 ! regulation of amino acid uptake involved in synaptic transmission +relationship: regulates GO:0051936 ! gamma-aminobutyric acid reuptake + +[Term] +id: GO:0051948 +name: negative regulation of glutamate uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of glutamate reuptake" EXACT [] +synonym: "negative regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of glutamate uptake involved in conduction of nerve impulse" RELATED [GOC:dph] +is_a: GO:0002037 ! negative regulation of L-glutamate import across plasma membrane +is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse +relationship: negatively_regulates GO:0051935 ! glutamate reuptake + +[Term] +id: GO:0051949 +name: negative regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "down-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "downregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "inhibition of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "negative regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "negative regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "negative regulation of GABA reuptake" EXACT [] +synonym: "negative regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "negative regulation of gamma-aminobutyric acid reuptake" EXACT [] +synonym: "negative regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] +is_a: GO:0051942 ! negative regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse +is_a: GO:1903792 ! negative regulation of anion transport +relationship: negatively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake + +[Term] +id: GO:0051950 +name: positive regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate) into a neuron or glial cell." [GOC:ai] +synonym: "activation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of 4-aminobutyrate reuptake" EXACT [] +synonym: "positive regulation of 4-aminobutyrate uptake during transmission of nerve impulse" EXACT [] +synonym: "positive regulation of GABA reuptake" EXACT [] +synonym: "positive regulation of GABA uptake during transmission of nerve impulse" EXACT [] +synonym: "positive regulation of gamma-aminobutyric acid reuptake" EXACT [] +synonym: "positive regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of gamma-aminobutyric acid uptake involved in conduction of nerve impulse" EXACT [GOC:dph] +synonym: "stimulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of gamma-aminobutyric acid uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051947 ! regulation of gamma-aminobutyric acid uptake involved in transmission of nerve impulse +is_a: GO:1903793 ! positive regulation of anion transport +relationship: positively_regulates GO:0051936 ! gamma-aminobutyric acid reuptake + +[Term] +id: GO:0051951 +name: positive regulation of glutamate uptake involved in transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of L-glutamate into a neuron or glial cell." [GOC:ai] +synonym: "activation of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "positive regulation of glutamate reuptake" EXACT [] +synonym: "positive regulation of glutamate uptake during transmission of nerve impulse" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of glutamate uptake involved in conduction of nerve impulse" EXACT [GOC:dph] +synonym: "stimulation of glutamate uptake during transmission of nerve impulse" NARROW [] +synonym: "up regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "up-regulation of glutamate uptake during transmission of nerve impulse" EXACT [] +synonym: "upregulation of glutamate uptake during transmission of nerve impulse" EXACT [] +is_a: GO:0002038 ! positive regulation of L-glutamate import across plasma membrane +is_a: GO:0051943 ! positive regulation of amino acid uptake involved in synaptic transmission +is_a: GO:0051946 ! regulation of glutamate uptake involved in transmission of nerve impulse +relationship: positively_regulates GO:0051935 ! glutamate reuptake + +[Term] +id: GO:0051952 +name: regulation of amine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051953 +name: negative regulation of amine transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of amine transport" EXACT [] +synonym: "down-regulation of amine transport" EXACT [] +synonym: "downregulation of amine transport" EXACT [] +synonym: "inhibition of amine transport" NARROW [] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051952 ! regulation of amine transport +relationship: negatively_regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051954 +name: positive regulation of amine transport +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of amine transport" NARROW [] +synonym: "stimulation of amine transport" NARROW [] +synonym: "up regulation of amine transport" EXACT [] +synonym: "up-regulation of amine transport" EXACT [] +synonym: "upregulation of amine transport" EXACT [] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051952 ! regulation of amine transport +relationship: positively_regulates GO:0015837 ! amine transport + +[Term] +id: GO:0051955 +name: regulation of amino acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +is_a: GO:0032890 ! regulation of organic acid transport +is_a: GO:0051952 ! regulation of amine transport +relationship: regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051956 +name: negative regulation of amino acid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "down regulation of amino acid transport" EXACT [] +synonym: "down-regulation of amino acid transport" EXACT [] +synonym: "downregulation of amino acid transport" EXACT [] +synonym: "inhibition of amino acid transport" NARROW [] +synonym: "negative regulation of amino acid transmembrane transport" EXACT [GOC:mah] +is_a: GO:0032891 ! negative regulation of organic acid transport +is_a: GO:0051953 ! negative regulation of amine transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: negatively_regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051957 +name: positive regulation of amino acid transport +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] +synonym: "activation of amino acid transport" NARROW [] +synonym: "positive regulation of amino acid transmembrane transport" EXACT [GOC:mah] +synonym: "stimulation of amino acid transport" NARROW [] +synonym: "up regulation of amino acid transport" EXACT [] +synonym: "up-regulation of amino acid transport" EXACT [] +synonym: "upregulation of amino acid transport" EXACT [] +is_a: GO:0032892 ! positive regulation of organic acid transport +is_a: GO:0051954 ! positive regulation of amine transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: positively_regulates GO:0006865 ! amino acid transport + +[Term] +id: GO:0051958 +name: methotrexate transport +namespace: biological_process +def: "The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:0051959 +name: dynein light intermediate chain binding +namespace: molecular_function +def: "Binding to a light intermediate chain of the dynein complex." [GOC:bf] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0051960 +name: regulation of nervous system development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051961 +name: negative regulation of nervous system development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +synonym: "down regulation of nervous system development" EXACT [] +synonym: "down-regulation of nervous system development" EXACT [] +synonym: "downregulation of nervous system development" EXACT [] +synonym: "inhibition of nervous system development" NARROW [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0051960 ! regulation of nervous system development +relationship: negatively_regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051962 +name: positive regulation of nervous system development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue." [GOC:ai] +synonym: "activation of nervous system development" NARROW [] +synonym: "stimulation of nervous system development" NARROW [] +synonym: "up regulation of nervous system development" EXACT [] +synonym: "up-regulation of nervous system development" EXACT [] +synonym: "upregulation of nervous system development" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0051960 ! regulation of nervous system development +relationship: positively_regulates GO:0007399 ! nervous system development + +[Term] +id: GO:0051963 +name: regulation of synapse assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] +subset: goslim_synapse +synonym: "regulation of synapse biogenesis" EXACT [] +synonym: "regulation of synaptogenesis" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: regulates GO:0007416 ! synapse assembly + +[Term] +id: GO:0051964 +name: negative regulation of synapse assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] +synonym: "down regulation of synapse assembly" EXACT [] +synonym: "down-regulation of synapse assembly" EXACT [] +synonym: "downregulation of synapse assembly" EXACT [] +synonym: "inhibition of synapse assembly" NARROW [] +synonym: "negative regulation of synapse biogenesis" EXACT [] +synonym: "negative regulation of synaptogenesis" EXACT [] +is_a: GO:0051961 ! negative regulation of nervous system development +is_a: GO:0051963 ! regulation of synapse assembly +is_a: GO:1901889 ! negative regulation of cell junction assembly +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0007416 ! synapse assembly + +[Term] +id: GO:0051965 +name: positive regulation of synapse assembly +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:ai, GOC:pr] +synonym: "activation of synapse assembly" NARROW [] +synonym: "positive regulation of synapse biogenesis" EXACT [] +synonym: "positive regulation of synaptogenesis" EXACT [] +synonym: "stimulation of synapse assembly" NARROW [] +synonym: "up regulation of synapse assembly" EXACT [] +synonym: "up-regulation of synapse assembly" EXACT [] +synonym: "upregulation of synapse assembly" EXACT [] +is_a: GO:0051962 ! positive regulation of nervous system development +is_a: GO:0051963 ! regulation of synapse assembly +is_a: GO:1901890 ! positive regulation of cell junction assembly +relationship: positively_regulates GO:0007416 ! synapse assembly + +[Term] +id: GO:0051966 +name: regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051967 +name: negative regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +synonym: "down regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "down-regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "downregulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "inhibition of synaptic transmission, glutamatergic" NARROW [] +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic +relationship: negatively_regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051968 +name: positive regulation of synaptic transmission, glutamatergic +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate." [GOC:ai] +synonym: "activation of synaptic transmission, glutamatergic" NARROW [] +synonym: "stimulation of synaptic transmission, glutamatergic" NARROW [] +synonym: "up regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "up-regulation of synaptic transmission, glutamatergic" EXACT [] +synonym: "upregulation of synaptic transmission, glutamatergic" EXACT [] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic +relationship: positively_regulates GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0051969 +name: regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +synonym: "regulation of conduction of nerve impulse" EXACT [GOC:dph] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0031644 ! regulation of nervous system process +relationship: regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051970 +name: negative regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +synonym: "down regulation of transmission of nerve impulse" EXACT [] +synonym: "down-regulation of transmission of nerve impulse" EXACT [] +synonym: "downregulation of transmission of nerve impulse" EXACT [] +synonym: "inhibition of transmission of nerve impulse" NARROW [] +synonym: "negative regulation of conduction of nerve impulse" EXACT [GOC:dph] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: negatively_regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051971 +name: positive regulation of transmission of nerve impulse +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation." [GOC:ai] +synonym: "activation of transmission of nerve impulse" NARROW [] +synonym: "positive regulation of conduction of nerve impulse" EXACT [GOC:dph] +synonym: "stimulation of transmission of nerve impulse" NARROW [] +synonym: "up regulation of transmission of nerve impulse" EXACT [] +synonym: "up-regulation of transmission of nerve impulse" EXACT [] +synonym: "upregulation of transmission of nerve impulse" EXACT [] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:0051969 ! regulation of transmission of nerve impulse +relationship: positively_regulates GO:0019226 ! transmission of nerve impulse + +[Term] +id: GO:0051972 +name: regulation of telomerase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [EC:2.-.-.-, GOC:ai] +synonym: "telomerase regulator" EXACT [] +is_a: GO:0051338 ! regulation of transferase activity +is_a: GO:2000278 ! regulation of DNA biosynthetic process + +[Term] +id: GO:0051973 +name: positive regulation of telomerase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] +synonym: "activation of telomerase activity" NARROW [] +synonym: "stimulation of telomerase activity" NARROW [] +synonym: "telomerase activator" RELATED [] +synonym: "up regulation of telomerase activity" EXACT [] +synonym: "up-regulation of telomerase activity" EXACT [] +synonym: "upregulation of telomerase activity" EXACT [] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:0051972 ! regulation of telomerase activity +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process + +[Term] +id: GO:0051974 +name: negative regulation of telomerase activity +namespace: biological_process +def: "Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [GOC:ai] +synonym: "down regulation of telomerase activity" EXACT [] +synonym: "down-regulation of telomerase activity" EXACT [] +synonym: "downregulation of telomerase activity" EXACT [] +synonym: "inhibition of telomerase activity" NARROW [] +synonym: "telomerase inhibitor" RELATED [] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:0051972 ! regulation of telomerase activity +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process + +[Term] +id: GO:0051975 +name: lysine biosynthetic process via alpha-aminoadipate and saccharopine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine." [MetaCyc:LYSINE-AMINOAD-PWY] +synonym: "lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [] +synonym: "lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [] +xref: MetaCyc:LYSINE-AMINOAD-PWY +is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:0051976 +name: lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine." [MetaCyc:PWY-3081] +synonym: "lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] +synonym: "lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate" EXACT [] +xref: MetaCyc:PWY-3081 +is_a: GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:0051977 +name: lysophospholipid transport +namespace: biological_process +def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] +is_a: GO:0015914 ! phospholipid transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0051978 +name: lysophospholipid:sodium symporter activity +namespace: molecular_function +def: "Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids." [GOC:ai] +synonym: "lysophospholipid transporter activity" BROAD [] +is_a: GO:0005436 ! sodium:phosphate symporter activity +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0051979 +name: alginic acid acetylation +namespace: biological_process +def: "The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate." [GOC:mlg] +synonym: "alginate acetylation" EXACT [] +is_a: GO:0042120 ! alginic acid metabolic process + +[Term] +id: GO:0051980 +name: iron-nicotianamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." [GOC:ai, PMID:20625001] +synonym: "Fe-NA chelate transporter activity" EXACT [] +is_a: GO:0015603 ! iron chelate transmembrane transporter activity + +[Term] +id: GO:0051981 +name: copper chelate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [PMID:26512647] +is_a: GO:0005375 ! copper ion transmembrane transporter activity + +[Term] +id: GO:0051982 +name: copper-nicotianamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other." [GOC:ai] +synonym: "Cu-NA chelate transporter activity" EXACT [] +is_a: GO:0051981 ! copper chelate transmembrane transporter activity + +[Term] +id: GO:0051983 +name: regulation of chromosome segregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051984 +name: positive regulation of chromosome segregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +synonym: "activation of chromosome segregation" NARROW [] +synonym: "stimulation of chromosome segregation" NARROW [] +synonym: "up regulation of chromosome segregation" EXACT [] +synonym: "up-regulation of chromosome segregation" EXACT [] +synonym: "upregulation of chromosome segregation" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: positively_regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051985 +name: negative regulation of chromosome segregation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] +synonym: "down regulation of chromosome segregation" EXACT [] +synonym: "down-regulation of chromosome segregation" EXACT [] +synonym: "downregulation of chromosome segregation" EXACT [] +synonym: "inhibition of chromosome segregation" NARROW [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: negatively_regulates GO:0007059 ! chromosome segregation + +[Term] +id: GO:0051986 +name: negative regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +synonym: "down regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "down-regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "downregulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "inhibition of attachment of spindle microtubules to kinetochore" NARROW [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0051985 ! negative regulation of chromosome segregation +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +relationship: negatively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051987 +name: positive regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +synonym: "activation of attachment of spindle microtubules to kinetochore" NARROW [] +synonym: "stimulation of attachment of spindle microtubules to kinetochore" NARROW [] +synonym: "up regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "upregulation of attachment of spindle microtubules to kinetochore" EXACT [] +is_a: GO:0051984 ! positive regulation of chromosome segregation +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051988 +name: regulation of attachment of spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore." [GOC:ai] +synonym: "regulation of kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0008608 ! attachment of spindle microtubules to kinetochore + +[Term] +id: GO:0051989 +name: coproporphyrinogen dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine." [EC:1.3.98.3] +synonym: "coproporphyrinogen III oxidase activity" RELATED [EC:1.3.98.3] +synonym: "coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)" RELATED [EC:1.3.98.3] +synonym: "HemN" RELATED [EC:1.3.98.3] +synonym: "oxygen-independent coproporphyrinogen-III oxidase activity" EXACT [] +synonym: "radical SAM enzyme activity" RELATED [EC:1.3.98.3] +xref: EC:1.3.98.3 +xref: MetaCyc:HEMN-RXN +xref: RHEA:15425 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0051990 +name: (R)-2-hydroxyglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." [EC:1.1.99.39, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] +synonym: "D-2-hydroxyglutarate dehydrogenase activity" EXACT [] +xref: EC:1.1.99.39 +xref: Reactome:R-HSA-880007 "(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2" +xref: Reactome:R-HSA-880053 "2-oxoglutarate + NADPH + H+ => (R)-2-hydroxyglutarate + NADP+ [mutant IDH1]" +xref: RHEA:38295 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0051991 +name: UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP." [MetaCyc:NACGLCTRANS-RXN] +comment: Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. +xref: EC:2.4.1.227 +xref: MetaCyc:NACGLCTRANS-RXN +xref: RHEA:31227 +is_a: GO:0008375 ! acetylglucosaminyltransferase activity + +[Term] +id: GO:0051992 +name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN] +comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. +subset: goslim_chembl +xref: EC:2.7.8.13 +xref: MetaCyc:PHOSNACMURPENTATRANS-RXN +xref: RHEA:28386 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0051993 +name: abscisic acid glucose ester beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose." [PMID:16990135] +synonym: "ABA-GE beta-glucosidase activity" EXACT [] +xref: EC:3.2.1.175 +xref: MetaCyc:RXN-11469 +xref: RHEA:31347 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0051994 +name: P-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule." [GOC:ai] +xref: EC:2.1.1.- +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0051995 +name: Se-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule." [GOC:ai] +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0051996 +name: squalene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate." [EC:2.5.1.21] +comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. +synonym: "squalene synthetase activity" RELATED [EC:2.5.1.21] +xref: EC:2.5.1.21 +xref: MetaCyc:RXN66-281 +is_a: GO:0004311 ! farnesyltranstransferase activity + +[Term] +id: GO:0051997 +name: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2." [MetaCyc:RXN-6201] +synonym: "4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity" EXACT [] +synonym: "OHCU decarboxylase activity" EXACT [] +xref: KEGG_REACTION:R06604 +xref: MetaCyc:RXN-6201 +xref: RHEA:26301 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0051998 +name: protein carboxyl O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group to a carboxyl group on a protein." [GOC:ai] +synonym: "protein carboxyl methyltransferase activity" EXACT [] +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0010340 ! carboxyl-O-methyltransferase activity + +[Term] +id: GO:0051999 +name: mannosyl-inositol phosphorylceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] +synonym: "mannose inositol phosphoceramide biosynthetic process" EXACT [] +synonym: "mannose-inositol-P-ceramide (MIPC) biosynthetic process" EXACT [] +synonym: "mannosyl-inositol phosphorylceramide anabolism" EXACT [] +synonym: "mannosyl-inositol phosphorylceramide biosynthesis" EXACT [] +synonym: "mannosyl-inositol phosphorylceramide formation" EXACT [] +synonym: "mannosyl-inositol phosphorylceramide synthesis" EXACT [] +synonym: "MIPC biosynthetic process" EXACT [] +is_a: GO:0006675 ! mannosyl-inositol phosphorylceramide metabolic process +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0052001 +name: type IV pili-dependent localized adherence to host +namespace: biological_process +def: "Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml] +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0052002 +name: obsolete metabolism by symbiont of substance in host +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052003 +name: suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +alt_id: GO:0052004 +alt_id: GO:0052252 +alt_id: GO:0052253 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "down regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "inhibition by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "negative modulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] +synonym: "negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related host SA-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "negative regulation of host SA-mediated defense response" EXACT [] +synonym: "suppression by organism of host salicylic acid-mediated defense response" EXACT [] +synonym: "suppression of host SA mediated defense response" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0010113 ! negative regulation of systemic acquired resistance +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway +is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response +relationship: negatively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway + +[Term] +id: GO:0052005 +name: suppression by symbiont of host ethylene-mediated defense response +namespace: biological_process +alt_id: GO:0052070 +alt_id: GO:0052254 +alt_id: GO:0052268 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "down-regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "downregulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "inhibition by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] +synonym: "negative regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "suppression by organism of host ethylene-mediated defense response" EXACT [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response + +[Term] +id: GO:0052006 +name: obsolete catabolism by symbiont of substance in host +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the breakdown of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of substance in host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052007 +name: obsolete biosynthesis by symbiont of substance in host +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its host resulting in the formation of substances. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "biosynthesis by organism of substance in host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052008 +name: disruption by symbiont of host cellular component +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism of host cellular component by organism" EXACT [] +synonym: "catabolism of host structural constituent by organism" EXACT [] +synonym: "degradation of host cellular component by organism" EXACT [] +synonym: "disassembly by organism of host cellular component" EXACT [] +synonym: "disassembly by symbiont of host cellular component" RELATED [] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0052009 +name: disruption by symbiont of host cell wall +namespace: biological_process +def: "A process carried out by a symbiont that breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "disassembly by symbiont of host cell wall" EXACT [] +is_a: GO:0098933 ! disruption by symbiont of host cell envelope + +[Term] +id: GO:0052010 +name: obsolete catabolism by symbiont of host cell wall cellulose +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host cell wall cellulose" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052011 +name: obsolete catabolism by symbiont of host cell wall pectin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host cell wall pectin" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052012 +name: obsolete catabolism by symbiont of host cell wall chitin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host cell wall chitin" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052013 +name: obsolete catabolism by symbiont of host macromolecule +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host macromolecule" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052014 +name: obsolete catabolism by symbiont of host protein +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host protein" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052015 +name: obsolete catabolism by symbiont of host carbohydrate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host carbohydrate" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052016 +name: obsolete catabolism by symbiont of host glucan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host glucan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052017 +name: obsolete catabolism by symbiont of host xylan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of host xylan" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052018 +name: modulation by symbiont of RNA levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by symbiont of host RNA levels" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0052019 +name: modulation by symbiont of host hormone or growth regulator levels +namespace: biological_process +alt_id: GO:0052186 +def: "The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0052020 +name: modification by symbiont of host cell wall +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "metabolism of host cell wall by organism" EXACT [] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0052021 +name: modulation by symbiont of ethylene levels in host +namespace: biological_process +alt_id: GO:0052449 +def: "The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of ethylene levels in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0052022 +name: modulation by symbiont of jasmonic acid levels in host +namespace: biological_process +alt_id: GO:0052456 +def: "The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0052023 +name: modulation by symbiont of salicylic acid levels in host +namespace: biological_process +alt_id: GO:0052469 +def: "The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0052024 +name: positive regulation by symbiont of hormone or growth regulator levels in host +namespace: biological_process +alt_id: GO:0052513 +def: "The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of hormone or growth regulator levels in host" NARROW [] +synonym: "positive modulation of hormone or growth regulator levels in host" EXACT [] +synonym: "positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction" BROAD [] +synonym: "stimulation by symbiont of hormone or growth regulator levels in host" NARROW [] +synonym: "up regulation by symbiont of hormone or growth regulator levels in host" EXACT [] +synonym: "up-regulation by symbiont of hormone or growth regulator levels in host" EXACT [] +synonym: "upregulation by symbiont of hormone or growth regulator levels in host" EXACT [] +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0052025 +name: modification by symbiont of host cell membrane +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a host cellular membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0052026 +name: modulation by symbiont of host transcription +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0044068 ! modulation by symbiont of host cellular process + +[Term] +id: GO:0052027 +name: modulation by symbiont of host signal transduction pathway +namespace: biological_process +alt_id: GO:0052250 +def: "Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by symbiont of host signal transduction" RELATED [] +synonym: "modulation of host signal transduction by symbiont" EXACT [] +synonym: "modulation of signal transduction in other organism involved in symbiotic interaction" BROAD [] +synonym: "regulation by symbiont of host signal transduction pathway" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:0044501 ! modulation of signal transduction in another organism + +[Term] +id: GO:0052028 +name: induction by symbiont of host signal transduction pathway +namespace: biological_process +alt_id: GO:0044502 +alt_id: GO:0052526 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "positive regulation of signal transduction in other organism" BROAD [] +synonym: "stimulation by symbiont of host signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "upregulation by symbiont of host signal transduction pathway" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0052029 +name: suppression by symbiont of host signal transduction pathway +namespace: biological_process +alt_id: GO:0052493 +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of host signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of host signal transduction pathway" NARROW [] +synonym: "negative modulation by organism of host signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of signal transduction in other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of host signal transduction pathway" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0052031 +name: modulation by symbiont of host defense response +namespace: biological_process +alt_id: GO:0052255 +def: "Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "mitigation by symbiont of host defense response" EXACT [] +synonym: "modulation by organism of defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "pathogenesis" RELATED [] +is_a: GO:0044003 ! modulation by symbiont of host process +is_a: GO:0052200 ! response to host defenses + +[Term] +id: GO:0052032 +name: modulation by symbiont of host inflammatory response +namespace: biological_process +alt_id: GO:0052256 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0052033 +name: obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] +comment: This term was obsoleted because it has been misused. +synonym: "general elicitor-dependent activation of host innate immunity" EXACT [] +synonym: "general elicitor-dependent induction of host innate immunity" EXACT [] +synonym: "MAMP dependent activation of host innate immunity" EXACT [] +synonym: "MAMP dependent induction of host innate immunity" EXACT [] +synonym: "PAMP dependent activation of host innate immunity" EXACT [] +synonym: "PAMP dependent induction of host innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent activation by organism of host innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity" EXACT [GOC:pg] +synonym: "pattern-triggered immunity" RELATED [GOC:tb] +synonym: "PTI" RELATED [GOC:tb] +is_obsolete: true +consider: GO:0002221 +consider: GO:0002752 +consider: GO:0052034 + +[Term] +id: GO:0052034 +name: effector-mediated suppression of host pattern-triggered immunity +namespace: biological_process +alt_id: GO:0052258 +def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] +synonym: "down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED [] +synonym: "down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED [] +synonym: "downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED [] +synonym: "inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity" RELATED [] +synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response" RELATED [] +synonym: "negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" RELATED [] +synonym: "suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response" BROAD [] +synonym: "suppression of general elicitor induced host innate immunity" RELATED [] +synonym: "suppression of general elicitor-induced host innate immunity" RELATED [] +synonym: "suppression of MAMP induced host innate immunity" RELATED [] +synonym: "suppression of MAMP-induced host innate immunity" RELATED [] +synonym: "suppression of PAMP induced host innate immunity" RELATED [] +synonym: "suppression of PAMP-induced host innate immunity" RELATED [] +synonym: "suppression of pathogen-associated molecular pattern-induced host innate immunity" RELATED [] +is_a: GO:0140403 ! effector-mediated suppression of host innate immune response + +[Term] +id: GO:0052035 +name: positive regulation by symbiont of host inflammatory response +namespace: biological_process +alt_id: GO:0052259 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host inflammatory response" NARROW [] +synonym: "positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] +synonym: "stimulation by symbiont of host inflammatory response" NARROW [] +synonym: "up regulation by symbiont of host inflammatory response" EXACT [] +synonym: "up-regulation by symbiont of host inflammatory response" EXACT [] +synonym: "upregulation by symbiont of host inflammatory response" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052032 ! modulation by symbiont of host inflammatory response + +[Term] +id: GO:0052036 +name: suppression by symbiont of host inflammatory response +namespace: biological_process +alt_id: GO:0052260 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host inflammatory response" EXACT [] +synonym: "down-regulation by symbiont of host inflammatory response" EXACT [] +synonym: "downregulation by symbiont of host inflammatory response" EXACT [] +synonym: "inhibition by symbiont of host inflammatory response" NARROW [] +synonym: "negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of host inflammatory response" EXACT [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052032 ! modulation by symbiont of host inflammatory response + +[Term] +id: GO:0052038 +name: modulation by symbiont of host intracellular transport +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation of host intracellular trafficking" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:0052039 +name: disruption by symbiont of host cytoskeleton +namespace: biological_process +alt_id: GO:0044054 +def: "The process in which an organism effects a change that impairs the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modification by symbiont of host cytoskeleton" RELATED [] +synonym: "rounding by symbiont of host cells" NARROW [] +is_a: GO:0052043 ! modification by symbiont of host cellular component + +[Term] +id: GO:0052040 +name: modulation by symbiont of host programmed cell death +namespace: biological_process +alt_id: GO:0052152 +def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by symbiont of host non-apoptotic programmed cell death" NARROW [] +synonym: "modulation of host PCD" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0052041 +name: negative regulation by symbiont of host programmed cell death +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host programmed cell death" EXACT [] +synonym: "down-regulation by symbiont of host programmed cell death" EXACT [] +synonym: "downregulation by symbiont of host programmed cell death" EXACT [] +synonym: "inhibition by symbiont of host programmed cell death" NARROW [] +synonym: "inhibition of host programmed cell death" EXACT [] +synonym: "suppression by symbiont of host PCD" EXACT [] +synonym: "suppression by symbiont of host programmed cell death" EXACT [] +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +relationship: negatively_regulates GO:0012501 ! programmed cell death + +[Term] +id: GO:0052042 +name: positive regulation by symbiont of host programmed cell death +namespace: biological_process +alt_id: GO:0012504 +alt_id: GO:0052044 +alt_id: GO:0052045 +alt_id: GO:0052153 +alt_id: GO:0052397 +alt_id: GO:0052400 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of host programmed cell death" EXACT [] +synonym: "activation by organism of non-apoptotic programmed cell death in other organism" NARROW [] +synonym: "activation by organism of programmed cell death in other organism during symbiotic interaction" EXACT [] +synonym: "activation by symbiont of host programmed cell death" NARROW [] +synonym: "enhancement of host programmed cell death" EXACT [] +synonym: "enhancement of host programmed cell death by organism" EXACT [] +synonym: "induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction" NARROW [] +synonym: "induction by organism of programmed cell death in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "induction by organism of programmed cell death in other organism involved in symbiotic interaction" EXACT [] +synonym: "induction by symbiont of host programmed cell death" EXACT [] +synonym: "induction of non-apoptotic programmed cell death by other organism" RELATED [] +synonym: "pathogenesis" RELATED [] +synonym: "positive regulation by symbiont of host non-apoptotic programmed cell death" NARROW [] +synonym: "stimulation by symbiont of host programmed cell death" NARROW [] +synonym: "upregulation by symbiont of host programmed cell death" EXACT [] +is_a: GO:0051712 ! positive regulation of killing of cells of another organism +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death +relationship: part_of GO:0001907 ! killing by symbiont of host cells + +[Term] +id: GO:0052043 +name: modification by symbiont of host cellular component +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052111 ! modification by symbiont of host structure + +[Term] +id: GO:0052046 +name: obsolete modification by symbiont of host morphology or physiology via secreted substance +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by one of the organisms. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification of host morphology or physiology via effector molecule" NARROW [] +synonym: "modification of host morphology or physiology via ellicitor" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052047 +name: obsolete symbiotic process mediated by secreted substance +namespace: biological_process +def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it has been misused to annotate host proteins. +synonym: "interaction with other organism via secreted substance during symbiotic interaction" RELATED [GOC:dph] +synonym: "interaction with other organism via secreted substance involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052048 +name: obsolete interaction with host via secreted substance +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflates a process and the mechanism of secretion of the gene product mediating the process. +synonym: "interaction with host via secreted substance during symbiotic interaction" RELATED [GOC:dph] +synonym: "interaction with host via secreted substance involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052049 +name: obsolete interaction with host via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type III secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052050 +name: obsolete interaction with host via substance secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type IV secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052051 +name: obsolete interaction with host via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052052 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type II secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052053 +name: negative regulation by symbiont of host catalytic activity +namespace: biological_process +alt_id: GO:0052056 +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host enzyme activity" EXACT [] +synonym: "down-regulation by symbiont of host enzyme activity" EXACT [] +synonym: "downregulation by symbiont of host enzyme activity" EXACT [] +synonym: "inhibition by symbiont of host enzyme activity" NARROW [] +synonym: "inhibition of host enzyme activity" EXACT [] +synonym: "negative regulation by symbiont of host enzyme activity" EXACT [] +synonym: "negative regulation by symbiont of host molecular function" BROAD [] +is_a: GO:0052148 ! modulation by symbiont of host catalytic activity + +[Term] +id: GO:0052054 +name: obsolete negative regulation by symbiont of host peptidase activity +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation by symbiont of host protease activity" NARROW [] +synonym: "down-regulation by symbiont of host protease activity" NARROW [] +synonym: "downregulation by symbiont of host protease activity" NARROW [] +synonym: "inhibition by symbiont of host protease activity" NARROW [] +synonym: "inhibition of host protease activity" NARROW [] +synonym: "negative regulation by symbiont of host protease activity" NARROW [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052055 +name: modulation by symbiont of host molecular function +namespace: biological_process +def: "The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "modification by symbiont of host molecular function" EXACT [] +synonym: "modification by symbiont of host protein function" EXACT [GOC:dph, GOC:tb] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0052057 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type III secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052058 +name: obsolete modification by symbiont of host morphology or physiology via substance secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type IV secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052062 +name: induction by symbiont of host phytoalexin production +namespace: biological_process +alt_id: GO:0052262 +def: "The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of host phytoalexin production" EXACT [] +synonym: "induction by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052063 +name: induction by symbiont of defense-related host nitric oxide production +namespace: biological_process +alt_id: GO:0052263 +alt_id: GO:0052345 +alt_id: GO:0052347 +def: "The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of defense-related host nitric oxide production" EXACT [] +synonym: "activation by organism of defense-related host NO production" EXACT [] +synonym: "activation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "induction by organism of defense-related host NO production" EXACT [] +synonym: "induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" RELATED [] +synonym: "positive regulation by organism of defense-related host NO production" RELATED [] +synonym: "positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "stimulation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "up regulation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "up-regulation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "upregulation by symbiont of defense-related host nitric oxide production" RELATED [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052064 +name: induction by symbiont of defense-related host reactive oxygen species production +namespace: biological_process +alt_id: GO:0052264 +alt_id: GO:0052348 +alt_id: GO:0052369 +def: "The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of defense-related host metabolic burst" EXACT [] +synonym: "activation by symbiont of defense-related host oxidative burst" EXACT [] +synonym: "activation by symbiont of defense-related host reactive oxidative species production" EXACT [] +synonym: "activation by symbiont of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "activation by symbiont of defense-related host reactive oxygen species production" EXACT [] +synonym: "activation by symbiont of defense-related host respiratory burst" EXACT [] +synonym: "activation by symbiont of defense-related host ROI production" EXACT [] +synonym: "activation by symbiont of defense-related host ROS production" EXACT [] +synonym: "induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by symbiont of defense-related host active oxygen species production" EXACT [] +synonym: "induction by symbiont of defense-related host AOS production" EXACT [] +synonym: "induction by symbiont of defense-related host metabolic burst" EXACT [] +synonym: "induction by symbiont of defense-related host oxidative burst" EXACT [] +synonym: "induction by symbiont of defense-related host reactive oxidative species production" EXACT [] +synonym: "induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +synonym: "stimulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +synonym: "up regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +synonym: "up-regulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +synonym: "upregulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052066 +name: obsolete entry of symbiont into host cell by promotion of host phagocytosis +namespace: biological_process +def: "OBSOLETE. The invasion by a symbiont of a host organism cell by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it was misused. +synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "entry of organism into cell of other organism by promotion of phagocytosis in other organism involved in symbiotic interaction" RELATED [] +synonym: "entry of organism into host cell by promotion of host phagocytosis" EXACT [] +synonym: "penetration of organism into host cell by promotion of host phagocytosis" EXACT [GOC:vw] +synonym: "penetration of symbiont into host cell by promotion of host phagocytosis" EXACT [GOC:vw] +is_obsolete: true + +[Term] +id: GO:0052067 +name: antiphagocytosis +namespace: biological_process +alt_id: GO:0052380 +alt_id: GO:0052483 +def: "Any process in which a symbiont avoids phagocytosis by a host cell, for example a phagocyte or a macrophage. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, PMID:23084912, PMID:29114249] +synonym: "down regulation by symbiont of entry into host cell via phagocytosis" RELATED [] +synonym: "down-regulation by symbiont of entry into host cell via phagocytosis" RELATED [] +synonym: "downregulation by symbiont of entry into host cell via phagocytosis" RELATED [] +synonym: "inhibition by symbiont of entry into host cell via phagocytosis" NARROW [] +synonym: "modulation by organism of entry into host via host phagocytosis" BROAD [] +synonym: "modulation by symbiont of entry into host via phagocytosis" BROAD [] +synonym: "negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction" RELATED [] +synonym: "negative regulation by organism of entry into host cell via host phagocytosis" RELATED [] +synonym: "negative regulation by symbiont of entry into host cell via phagocytosis" RELATED [] +synonym: "phagocytosis avoidence" EXACT [] +is_a: GO:0030682 ! mitigation of host defenses by symbiont + +[Term] +id: GO:0052072 +name: induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +alt_id: GO:0052270 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway" EXACT [] +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0052074 ! positive regulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:0052081 ! modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway + +[Term] +id: GO:0052074 +name: positive regulation by symbiont of host salicylic acid-mediated defense response +namespace: biological_process +alt_id: GO:0052272 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "induction by organism of host SA-mediated defense response" NARROW [] +synonym: "induction by organism of host salicylic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of host SA-mediated defense response" EXACT [] +synonym: "positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "stimulation by symbiont of host salicylic acid-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +synonym: "upregulation by symbiont of host salicylic acid-mediated defense response" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052089 ! modulation by symbiont of host salicylic acid-mediated defense response +is_a: GO:1901672 ! positive regulation of systemic acquired resistance +relationship: positively_regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway + +[Term] +id: GO:0052075 +name: positive regulation by symbiont of host jasmonic acid-mediated defense response +namespace: biological_process +alt_id: GO:0052273 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "induction by organism of host JA-mediated defense response" NARROW [] +synonym: "induction by organism of host jasmonic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of host JA-mediated defense response" EXACT [] +synonym: "positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "stimulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +synonym: "upregulation by symbiont of host jasmonic acid-mediated defense response" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052076 +name: induction by symbiont of host ethylene-mediated defense response +namespace: biological_process +alt_id: GO:0052071 +alt_id: GO:0052269 +alt_id: GO:0052274 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] +synonym: "positive regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "stimulation by symbiont of host ethylene-mediated defense response" NARROW [] +synonym: "up regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "up-regulation by symbiont of host ethylene-mediated defense response" EXACT [] +synonym: "upregulation by symbiont of host ethylene-mediated defense response" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0052084 ! modulation by symbiont of host ethylene-mediated defense response + +[Term] +id: GO:0052078 +name: suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +namespace: biological_process +alt_id: GO:0052275 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0052080 ! modulation by symbiont of host innate immune response MAPK kinase signaling +is_a: GO:0075132 ! suppression by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052079 +name: induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway +namespace: biological_process +alt_id: GO:0052276 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0052080 ! modulation by symbiont of host innate immune response MAPK kinase signaling +is_a: GO:0075131 ! induction by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052080 +name: modulation by symbiont of host innate immune response MAPK kinase signaling +namespace: biological_process +alt_id: GO:0052277 +def: "Any process in which an organism modulates the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway" RELATED [] +synonym: "modulation of defense-related host MAPK-mediated signal transduction pathway by organism" EXACT [] +synonym: "modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0052081 +name: modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +namespace: biological_process +alt_id: GO:0052445 +def: "Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation of defense-related host SA-mediated signal transduction pathway by organism" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0052083 +name: suppression by symbiont of host cell-mediated immune response +namespace: biological_process +alt_id: GO:0052278 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host cell-mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host cell-mediated immune response" NARROW [] +synonym: "negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by organism of host cell-based immune response" EXACT [] +is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response +is_a: GO:0052562 ! suppression by symbiont of host immune response + +[Term] +id: GO:0052084 +name: modulation by symbiont of host ethylene-mediated defense response +namespace: biological_process +alt_id: GO:0052077 +alt_id: GO:0052279 +alt_id: GO:0052441 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway" BROAD [] +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0052085 +name: suppression by symbiont of host T-cell mediated immune response +namespace: biological_process +alt_id: GO:0052280 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host T-cell mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host T-cell mediated immune response" NARROW [] +synonym: "negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of host T-cell mediated immune response" EXACT [] +is_a: GO:0052083 ! suppression by symbiont of host cell-mediated immune response +is_a: GO:0052156 ! modulation by symbiont of host T-cell mediated immune response + +[Term] +id: GO:0052086 +name: suppression by symbiont of host B-cell mediated immune response +namespace: biological_process +alt_id: GO:0052281 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "down-regulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "downregulation by symbiont of host B-cell mediated immune response" EXACT [] +synonym: "inhibition by symbiont of host B-cell mediated immune response" NARROW [] +synonym: "negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052083 ! suppression by symbiont of host cell-mediated immune response +is_a: GO:0052154 ! modulation by symbiont of host B-cell mediated immune response + +[Term] +id: GO:0052088 +name: symbiont defense to host-produced jasmonic acid +namespace: biological_process +alt_id: GO:0052068 +alt_id: GO:0052069 +alt_id: GO:0052073 +alt_id: GO:0052082 +alt_id: GO:0052266 +alt_id: GO:0052267 +alt_id: GO:0052271 +alt_id: GO:0052283 +alt_id: GO:0052443 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "down regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "down-regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "downregulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "inhibition by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [] +synonym: "modulation by organism of host JA-mediated defense response" NARROW [] +synonym: "modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [] +synonym: "modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction" NARROW [] +synonym: "negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "negative regulation by symbiont of host jasmonic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction" NARROW [] +synonym: "positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "suppression by organism of host JA-mediated defense response" EXACT [] +synonym: "suppression by symbiont of host jasmonic acid-mediated defense response" RELATED [] +synonym: "up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related host SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway" NARROW [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0052089 +name: modulation by symbiont of host salicylic acid-mediated defense response +namespace: biological_process +alt_id: GO:0052284 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of host SA-mediated defense response" EXACT [] +synonym: "modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0010112 ! regulation of systemic acquired resistance +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:0052031 ! modulation by symbiont of host defense response +is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway +relationship: regulates GO:0009862 ! systemic acquired resistance, salicylic acid mediated signaling pathway + +[Term] +id: GO:0052091 +name: modulation of nutrient release by host +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by symbiont of nutrient release from host" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process +relationship: part_of GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0052092 +name: positive regulation of nutrient release by host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of nutrient release from host" NARROW [] +synonym: "positive regulation by symbiont of nutrient release from host" EXACT [] +synonym: "promotion of nutrient release from host" EXACT [] +synonym: "stimulation by symbiont of nutrient release from host" NARROW [] +synonym: "up regulation by symbiont of nutrient release from host" EXACT [] +synonym: "up-regulation by symbiont of nutrient release from host" EXACT [] +synonym: "upregulation by symbiont of nutrient release from host" EXACT [] +is_a: GO:0052091 ! modulation of nutrient release by host + +[Term] +id: GO:0052093 +name: formation of specialized structure for nutrient acquisition +namespace: biological_process +def: "The assembly of a symbiotic cellular or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "formation by organism of specialized structure for nutrient acquisition from host" EXACT [] +synonym: "formation by symbiont of specialized structure for nutrient acquisition from host" EXACT [] +synonym: "formation of specialized structure for nutrient acquisition from host" EXACT [] +is_a: GO:0044111 ! formation of structure involved in a symbiotic process +relationship: part_of GO:0044002 ! acquisition of nutrients from host + +[Term] +id: GO:0052094 +name: formation of haustorium for nutrient acquisition +namespace: biological_process +def: "The assembly of a haustorium, a projection from a symbiotic cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "formation by organism of haustoria for nutrient acquisition from host" EXACT [] +synonym: "formation by organism of haustorium for nutrient acquisition from host" EXACT [] +synonym: "formation by symbiont of haustorium for nutrient acquisition from host" RELATED [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition + +[Term] +id: GO:0052095 +name: obsolete formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052096 +name: formation of syncytium involving giant cell for nutrient acquisition +namespace: biological_process +def: "The assembly of a syncytium, a multi-nucleate and physiologically active aggregation of fused root cells induced by a symbiotic nematode in a plant host. The syncytium exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "formation by organism of syncytium involving giant cell for nutrient acquisition from host" EXACT [] +synonym: "formation by symbiont of syncytium involving giant cell for nutrient acquisition from host" RELATED [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition + +[Term] +id: GO:0052097 +name: obsolete interspecies quorum sensing +namespace: biological_process +def: "OBSOLETE. The process in which a community of single-celled organisms of different species monitors population density by detecting the concentration of small diffusible signal molecules." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that this term was an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0052098 +name: formation by host of specialized structure for nutrient acquisition from symbiont +namespace: biological_process +def: "The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051702 ! biological process involved in interaction with symbiont +relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont + +[Term] +id: GO:0052100 +name: obsolete intraspecies quorum sensing +namespace: biological_process +def: "OBSOLETE. The process in which single-celled organisms of the same species monitor population density by detecting the concentration of small, diffusible signal molecules." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that this term was an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0052102 +name: positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway +namespace: biological_process +alt_id: GO:0052287 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] +synonym: "positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation of defense-related host CDPK pathway by organism" EXACT [] +synonym: "stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway" NARROW [] +synonym: "up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +synonym: "up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +synonym: "upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway" EXACT [] +is_a: GO:0044416 ! induction by symbiont of host defense response + +[Term] +id: GO:0052103 +name: induction by symbiont of host induced systemic resistance +namespace: biological_process +alt_id: GO:0052288 +alt_id: GO:0052532 +alt_id: GO:0052533 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of induced systemic resistance in host" EXACT [] +synonym: "activation by organism of ISR in host" EXACT [] +synonym: "activation by symbiont of induced systemic resistance in host" NARROW [] +synonym: "induction by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by organism of ISR in host" EXACT [] +synonym: "induction by symbiont of induced systemic resistance in host" EXACT [] +synonym: "positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of host induced systemic resistance" RELATED [] +synonym: "positive regulation by symbiont of induced systemic resistance in host" RELATED [] +synonym: "stimulation by symbiont of induced systemic resistance in host" NARROW [] +synonym: "up regulation by symbiont of induced systemic resistance in host" RELATED [] +synonym: "up-regulation by symbiont of induced systemic resistance in host" RELATED [] +synonym: "upregulation by symbiont of induced systemic resistance in host" RELATED [] +is_a: GO:0052159 ! modulation by symbiont of host induced systemic resistance +is_a: GO:0052390 ! induction by symbiont of host innate immune response + +[Term] +id: GO:0052104 +name: induction by symbiont of host systemic acquired resistance +namespace: biological_process +alt_id: GO:0052289 +alt_id: GO:0052535 +alt_id: GO:0052537 +def: "Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of SAR in host" EXACT [] +synonym: "activation by organism of systemic acquired resistance in host" EXACT [] +synonym: "induction by organism of SAR in host" EXACT [] +synonym: "induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by symbiont of systemic acquired resistance in host" EXACT [] +synonym: "positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of host systemic acquired resistance" RELATED [] +synonym: "positive regulation by symbiont of systemic acquired resistance in host" RELATED [] +synonym: "stimulation by symbiont of systemic acquired resistance in host" RELATED [] +synonym: "up regulation by symbiont of systemic acquired resistance in host" RELATED [] +synonym: "up-regulation by symbiont of systemic acquired resistance in host" RELATED [] +synonym: "upregulation by symbiont of systemic acquired resistance in host" RELATED [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052160 ! modulation by symbiont of host systemic acquired resistance +is_a: GO:0052390 ! induction by symbiont of host innate immune response + +[Term] +id: GO:0052105 +name: obsolete induction by symbiont of defense-related host cell wall thickening +namespace: biological_process +alt_id: GO:0052290 +alt_id: GO:0052538 +alt_id: GO:0052539 +def: "OBSOLETE. The activation by an organism of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. +synonym: "activation by organism of defense-related host cell wall thickening" EXACT [] +synonym: "activation by organism of host defensive cell wall thickening" EXACT [] +synonym: "activation by symbiont of defense-related host cell wall thickening" EXACT [] +synonym: "induction by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by organism of host defensive cell wall thickening" EXACT [] +synonym: "positive regulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of host defensive cell wall thickening" RELATED [] +synonym: "positive regulation by symbiont of defense-related host cell wall thickening" RELATED [] +synonym: "stimulation by symbiont of defense-related host cell wall thickening" RELATED [] +synonym: "up regulation by symbiont of defense-related host cell wall thickening" RELATED [] +synonym: "up-regulation by symbiont of defense-related host cell wall thickening" RELATED [] +synonym: "upregulation by symbiont of defense-related host cell wall thickening" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052106 +name: obsolete quorum sensing involved in interaction with host +namespace: biological_process +def: "OBSOLETE. The process in which a community of single-celled organisms living in intimate contact with a host organism monitors population density by detecting the concentration of small diffusible signal molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that this term was not clearly defined and usage was inconsistent. +synonym: "quorum sensing during interaction with host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052108 +name: obsolete growth or development of symbiont during interaction with host +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development of organism during interaction with host" EXACT [] +synonym: "growth or development of organism in response to host" EXACT [] +synonym: "growth or development of symbiont during interaction with host" EXACT [] +is_obsolete: true +consider: GO:0044111 +consider: GO:0051701 + +[Term] +id: GO:0052109 +name: obsolete induction by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +alt_id: GO:0052107 +alt_id: GO:0052291 +alt_id: GO:0052292 +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. +synonym: "activation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of defense-related host callose deposition" RELATED [] +synonym: "positive regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] +synonym: "stimulation by symbiont of defense-related host cell wall callose deposition" RELATED [] +synonym: "up regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] +synonym: "up-regulation by symbiont of defense-related host cell wall callose deposition" RELATED [] +synonym: "upregulation by symbiont of defense-related host cell wall callose deposition" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052110 +name: occlusion by symbiont of host vascular system +namespace: biological_process +def: "The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +is_a: GO:0052111 ! modification by symbiont of host structure + +[Term] +id: GO:0052111 +name: modification by symbiont of host structure +namespace: biological_process +def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0052112 +name: occlusion by symbiont of host xylem +namespace: biological_process +def: "The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052110 ! occlusion by symbiont of host vascular system + +[Term] +id: GO:0052113 +name: obsolete adaptation to host osmotic environment +namespace: biological_process +def: "OBSOLETE. The responsive adjustment of an organism to the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. +synonym: "adaptation to host osmotic environment" EXACT [] +synonym: "osmotic tolerance to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052114 +name: obsolete adaptation to host pH environment +namespace: biological_process +def: "OBSOLETE. The responsive adjustment of an organism to the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because adaptation was not deemed to be a valid biological process. +synonym: "adaptation to host pH environment" EXACT [] +synonym: "pH tolerance to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052115 +name: obsolete energy taxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in the environment of its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "energy taxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052116 +name: obsolete chemotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "chemotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052117 +name: obsolete aerotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "aerotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052118 +name: obsolete positive energy taxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive energy taxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052119 +name: obsolete negative energy taxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative energy taxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052120 +name: obsolete positive aerotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive aerotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052121 +name: obsolete positive chemotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive chemotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052122 +name: obsolete negative aerotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative aerotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052123 +name: obsolete negative chemotaxis in host environment +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative chemotaxis in response to host environment" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052124 +name: obsolete energy taxis within host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052125 +name: obsolete energy taxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052126 +name: movement in host environment +namespace: biological_process +def: "The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "movement in response to host" EXACT [] +is_a: GO:0051701 ! biological process involved in interaction with host + +[Term] +id: GO:0052127 +name: obsolete movement on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of an organism or motile cell on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052128 +name: positive energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0052129 +name: negative energy taxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:mtg_pamgo_17jul06] +is_a: GO:0009453 ! energy taxis + +[Term] +id: GO:0052130 +name: negative aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] +is_a: GO:0009454 ! aerotaxis +is_a: GO:0050919 ! negative chemotaxis +is_a: GO:0052129 ! negative energy taxis + +[Term] +id: GO:0052131 +name: positive aerotaxis +namespace: biological_process +def: "The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen." [GOC:dph, GOC:mtg_pamgo_17jul06] +is_a: GO:0009454 ! aerotaxis +is_a: GO:0050918 ! positive chemotaxis +is_a: GO:0052128 ! positive energy taxis + +[Term] +id: GO:0052132 +name: obsolete positive aerotaxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052133 +name: obsolete positive aerotaxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive aerotaxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052134 +name: obsolete negative aerotaxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052135 +name: obsolete negative aerotaxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative aerotaxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052136 +name: obsolete negative chemotaxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052137 +name: obsolete aerotaxis in host +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "aerotaxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052138 +name: obsolete aerotaxis on or near host +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052139 +name: obsolete negative chemotaxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative chemotaxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052140 +name: obsolete positive chemotaxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive chemotaxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052141 +name: obsolete positive chemotaxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052142 +name: obsolete chemotaxis within host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052143 +name: obsolete chemotaxis on or near host involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "chemotaxis on or near host during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052144 +name: obsolete negative energy taxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative energy taxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052145 +name: obsolete negative energy taxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052146 +name: obsolete positive energy taxis on or near host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +is_obsolete: true + +[Term] +id: GO:0052147 +name: obsolete positive energy taxis in host +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within its host organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive energy taxis within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052148 +name: modulation by symbiont of host catalytic activity +namespace: biological_process +def: "The process in which an organism effects a change in host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "modulation by symbiont of host enzyme activity" EXACT [GOC:tb] +synonym: "modulation of catalytic activity of host by symbiont" EXACT [] +synonym: "regulation by symbiont of host catalytic activity" EXACT [] +synonym: "regulation of catalytic activity of host by symbiont" EXACT [] +synonym: "regulation of host catalytic activity by symbiont" EXACT [] +is_a: GO:0052055 ! modulation by symbiont of host molecular function + +[Term] +id: GO:0052149 +name: obsolete modulation by symbiont of host peptidase activity +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in host peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "modulation by symbiont of host protease activity" NARROW [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0052150 +name: modulation by symbiont of host apoptotic process +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. +synonym: "modulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "modulation by symbiont of host apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:0051709 ! regulation of killing of cells of another organism +is_a: GO:0052040 ! modulation by symbiont of host programmed cell death + +[Term] +id: GO:0052151 +name: positive regulation by symbiont of host apoptotic process +namespace: biological_process +alt_id: GO:0033669 +alt_id: GO:0052030 +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mtg_pamgo_17jul06] +comment: Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. +synonym: "activation by organism of host apoptosis" EXACT [] +synonym: "activation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "activation by symbiont of host apoptosis" NARROW [] +synonym: "induction by organism of host apoptotic programmed cell death" EXACT [] +synonym: "induction by symbiont of host apoptosis" EXACT [] +synonym: "positive regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "positive regulation by symbiont of host apoptosis" NARROW [] +synonym: "stimulation by symbiont of host apoptosis" NARROW [] +synonym: "up regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "up regulation by symbiont of host apoptosis" EXACT [] +synonym: "up-regulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "up-regulation by symbiont of host apoptosis" EXACT [] +synonym: "upregulation by organism of host apoptotic programmed cell death" EXACT [] +synonym: "upregulation by symbiont of host apoptosis" EXACT [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052150 ! modulation by symbiont of host apoptotic process + +[Term] +id: GO:0052154 +name: modulation by symbiont of host B-cell mediated immune response +namespace: biological_process +alt_id: GO:0052293 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "regulation by organism of host B-cell mediated immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052155 +name: modulation by symbiont of host cell-mediated immune response +namespace: biological_process +alt_id: GO:0052294 +def: "Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of host cell-based immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052156 +name: modulation by symbiont of host T-cell mediated immune response +namespace: biological_process +alt_id: GO:0052295 +def: "Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052155 ! modulation by symbiont of host cell-mediated immune response + +[Term] +id: GO:0052157 +name: obsolete modulation by symbiont of microbe-associated molecular pattern-induced host innate immune response +namespace: biological_process +alt_id: GO:0052296 +def: "OBSOLETE. Any process that involves recognition of a microbe-associated molecular pattern, and by which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] +comment: The reason for obsoletion is that this term has been misused. +synonym: "modulation by organism of microbe-associated molecular pattern-induced innate immune response in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of microbe-associated molecular pattern-induced host innate immunity" EXACT [GOC:pg] +synonym: "modulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052158 +name: modulation by symbiont of host resistance gene-dependent defense response +namespace: biological_process +alt_id: GO:0052297 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense response in host by specific elicitors" EXACT [] +synonym: "modulation by organism of host gene-for-gene resistance" EXACT [] +synonym: "modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0052159 +name: modulation by symbiont of host induced systemic resistance +namespace: biological_process +alt_id: GO:0052298 +def: "Any process in which a symbiont modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of induced systemic resistance in host" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052160 +name: modulation by symbiont of host systemic acquired resistance +namespace: biological_process +alt_id: GO:0052299 +def: "Any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of systemic acquired resistance in host" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052161 +name: obsolete modulation by symbiont of defense-related host cell wall thickening +namespace: biological_process +alt_id: GO:0052300 +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. +synonym: "modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of host defensive cell wall thickening" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052162 +name: modulation by symbiont of defense-related host calcium ion flux +namespace: biological_process +alt_id: GO:0052301 +def: "Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of defense-related host Ca2+ flux" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +is_a: GO:0050848 ! regulation of calcium-mediated signaling +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0052163 +name: symbiont defense to host-produced nitric oxide +namespace: biological_process +alt_id: GO:0052060 +alt_id: GO:0052302 +alt_id: GO:0052376 +alt_id: GO:0052551 +alt_id: GO:0052565 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "defense response to host innate immune response nitric oxide production" NARROW [] +synonym: "evasion or tolerance by organism of host nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of host NO" EXACT [] +synonym: "evasion or tolerance by organism of host-produced nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of host-produced NO" EXACT [] +synonym: "evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction" BROAD [] +synonym: "evasion or tolerance by symbiont of host-produced nitric oxide" EXACT [] +synonym: "evasion or tolerance of nitric oxide produced by host in response to organism" EXACT [] +synonym: "evasion or tolerance of NO produced by host in response to organism" EXACT [] +synonym: "modulation by organism of defense-related host NO production" EXACT [] +synonym: "modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of defense-related host nitric oxide production" RELATED [] +synonym: "response to defense-related host nitric oxide production" RELATED [] +synonym: "response to defense-related nitric oxide production by other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0042783 ! evasion of host immune response +is_a: GO:0071500 ! cellular response to nitrosative stress + +[Term] +id: GO:0052164 +name: symbiont defense to host-produced reactive oxygen species +namespace: biological_process +alt_id: GO:0052059 +alt_id: GO:0052303 +alt_id: GO:0052385 +alt_id: GO:0052550 +alt_id: GO:0052567 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion by symbiont of cellular damage caused by host oxidative burst" NARROW [] +synonym: "evasion or tolerance by organism of host-produced reactive oxygen species" EXACT [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced during host defense response" EXACT [] +synonym: "evasion or tolerance by symbiont of host-produced reactive oxygen species" EXACT [] +synonym: "evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction" BROAD [] +synonym: "evasion or tolerance of defense-related host metabolic burst" EXACT [] +synonym: "evasion or tolerance of defense-related host oxidative burst" EXACT [] +synonym: "evasion or tolerance of defense-related host respiratory burst" EXACT [] +synonym: "evasion or tolerance of host-produced active oxygen species" EXACT [] +synonym: "evasion or tolerance of host-produced AOS" EXACT [] +synonym: "evasion or tolerance of host-produced reactive oxygen intermediates" EXACT [] +synonym: "evasion or tolerance of host-produced ROIs" EXACT [] +synonym: "evasion or tolerance of host-produced ROS" EXACT [] +synonym: "evasion or tolerance of reactive oxygen species produced by host" EXACT [] +synonym: "modulation by organism of defense-related host active oxygen species production" EXACT [] +synonym: "modulation by organism of defense-related host AOS production" EXACT [] +synonym: "modulation by organism of defense-related host metabolic burst" EXACT [] +synonym: "modulation by organism of defense-related host oxidative burst" EXACT [] +synonym: "modulation by organism of defense-related host reactive oxidative species production" EXACT [] +synonym: "modulation by organism of defense-related host reactive oxygen intermediate production" EXACT [] +synonym: "modulation by organism of defense-related host respiratory burst" EXACT [] +synonym: "modulation by organism of defense-related host ROI production" EXACT [] +synonym: "modulation by organism of defense-related host ROS production" EXACT [] +synonym: "modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of defense-related host reactive oxygen species production" RELATED [] +synonym: "response to defense-related host reactive oxygen species production" RELATED [] +synonym: "response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0052165 +name: symbiont defense to host-produced phytoalexin +namespace: biological_process +alt_id: GO:0052061 +alt_id: GO:0052304 +alt_id: GO:0052378 +alt_id: GO:0052549 +alt_id: GO:0052566 +def: "Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "evasion or tolerance by symbiont of host-produced phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins produced by host in response to organism" EXACT [] +synonym: "host phytoalexin detoxification" NARROW [] +synonym: "modulation by organism of phytoalexin production in other organism involved in symbiotic interaction" NARROW [] +synonym: "modulation by symbiont of host phytoalexin production" NARROW [] +synonym: "phytoalexin detoxification" NARROW [] +synonym: "response to host phytoalexin production" BROAD [] +synonym: "response to phytoalexin production by other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0042783 ! evasion of host immune response + +[Term] +id: GO:0052167 +name: modulation by symbiont of host innate immune response +namespace: biological_process +alt_id: GO:0052306 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of innate immune response in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of host innate immunity" EXACT [GOC:pg] +synonym: "modulation of host innate immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052168 +name: modulation by symbiont of defense-related host calcium-dependent protein kinase pathway +namespace: biological_process +alt_id: GO:0052307 +def: "Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of defense-related host CDPK pathway" EXACT [] +is_a: GO:0052031 ! modulation by symbiont of host defense response + +[Term] +id: GO:0052169 +name: obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response +namespace: biological_process +def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah] +comment: This term was obsoleted because it has been misused. +synonym: "pathogen-associated molecular pattern dependent modulation by symbiont of host innate immunity" EXACT [GOC:pg] +is_obsolete: true +consider: GO:0002221 +consider: GO:0002752 +consider: GO:0052034 + +[Term] +id: GO:0052170 +name: suppression by symbiont of host innate immune response +namespace: biological_process +alt_id: GO:0052309 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host innate immunity" EXACT [] +synonym: "down-regulation by symbiont of host innate immunity" EXACT [] +synonym: "downregulation by symbiont of host innate immunity" EXACT [] +synonym: "inhibition by symbiont of host innate immunity" NARROW [] +synonym: "negative regulation by symbiont of host innate immune response" EXACT [] +synonym: "negative regulation by symbiont of host innate immunity" EXACT [GOC:pg] +synonym: "negative regulation of host innate immune response" EXACT [] +synonym: "negative regulation of innate immune response in other organism" BROAD [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0052167 ! modulation by symbiont of host innate immune response +is_a: GO:0052562 ! suppression by symbiont of host immune response + +[Term] +id: GO:0052171 +name: obsolete growth or development during symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development during symbiotic interaction" EXACT [] +is_obsolete: true +consider: GO:0044111 + +[Term] +id: GO:0052172 +name: obsolete metabolism by symbiont of host cell wall cellulose +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052173 +name: response to defenses of other organism +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism." [GOC:mtg_pamgo_17jul06] +synonym: "response to defenses of other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "response to defenses of other organism involved in symbiotic interaction" RELATED [] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0052174 +name: obsolete metabolism by symbiont of host macromolecule +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052175 +name: obsolete metabolism by symbiont of host carbohydrate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052176 +name: obsolete metabolism by symbiont of host glucan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052177 +name: obsolete metabolism by symbiont of host xylan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0052178 +name: obsolete metabolism by symbiont of host cell wall chitin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052179 +name: obsolete metabolism by symbiont of host cell wall pectin +namespace: biological_process +alt_id: GO:0052413 +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052180 +name: obsolete negative regulation of peptidase activity in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protease activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of protease activity in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of protease activity in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of protease activity in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052181 +name: obsolete modulation by host of symbiont defense response +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. +is_obsolete: true + +[Term] +id: GO:0052182 +name: obsolete modification by host of symbiont morphology or physiology via secreted substance +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by a substance secreted by one of the organisms. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0052183 +name: modification by host of symbiont structure +namespace: biological_process +def: "The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0052184 +name: obsolete modulation by organism of symbiont hormone or growth regulator levels +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont hormone or growth regulator levels" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052185 +name: obsolete modification of structure of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification of structure of other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052187 +name: modification by host of symbiont cellular component +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052183 ! modification by host of symbiont structure + +[Term] +id: GO:0052188 +name: obsolete modification of cellular component in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052189 +name: obsolete modulation by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +alt_id: GO:0052090 +alt_id: GO:0052285 +alt_id: GO:0052310 +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. +synonym: "modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] +synonym: "modulation by symbiont of defense-related host callose deposition" BROAD [] +is_obsolete: true + +[Term] +id: GO:0052190 +name: obsolete modulation by symbiont of host phagocytosis +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0052191 +name: obsolete positive regulation by symbiont of host phagocytosis +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "activation by symbiont of host phagocytosis" NARROW [] +synonym: "stimulation by symbiont of host phagocytosis" NARROW [] +synonym: "up regulation by symbiont of host phagocytosis" EXACT [] +synonym: "up-regulation by symbiont of host phagocytosis" EXACT [] +synonym: "upregulation by symbiont of host phagocytosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052192 +name: obsolete movement in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of an organism or motile cell on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "locomotion in environment of other organism during symbiotic interaction" RELATED [] +synonym: "movement in environment of other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052193 +name: obsolete movement in symbiont environment +namespace: biological_process +def: "OBSOLETE. The directed movement of an organism or motile cell on, within or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_obsolete: true + +[Term] +id: GO:0052194 +name: obsolete movement on or near symbiont +namespace: biological_process +def: "OBSOLETE. The directed movement of an organism or motile cell on or near its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_obsolete: true + +[Term] +id: GO:0052195 +name: obsolete movement on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of an organism or motile cell on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "movement on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052196 +name: obsolete negative regulation by host of symbiont defense response +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was made obsolete because it is not relevant for the host in a host-symbiont interaction. +synonym: "down regulation by host of symbiont defense response" EXACT [] +synonym: "down-regulation by host of symbiont defense response" EXACT [] +synonym: "downregulation by host of symbiont defense response" EXACT [] +synonym: "inhibition by host of symbiont defense response" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052197 +name: obsolete positive regulation by host of symbiont defense response +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. +synonym: "activation by host of symbiont defense response" NARROW [] +synonym: "stimulation by host of symbiont defense response" NARROW [] +synonym: "up regulation by host of symbiont defense response" EXACT [] +synonym: "up-regulation by host of symbiont defense response" EXACT [] +synonym: "upregulation by host of symbiont defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052198 +name: obsolete modulation of peptidase activity in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "modulation of protease activity in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "modulation of protease activity in other organism involved in symbiotic interaction" NARROW [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0052199 +name: obsolete negative regulation of catalytic activity in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it was an unnecessary grouping term. +synonym: "down regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +synonym: "down-regulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +synonym: "downregulation of enzyme activity in other organism during symbiotic interaction" RELATED [] +synonym: "inhibition of enzyme activity in other organism" EXACT [] +synonym: "inhibition of enzyme activity in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of enzyme activity in other organism during symbiotic interaction" EXACT [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052200 +name: response to host defenses +namespace: biological_process +alt_id: GO:0075140 +alt_id: GO:0075145 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "maintenance of symbiont tolerance to host defense molecules" NARROW [] +synonym: "response of symbiont to host defense molecules" NARROW [] +synonym: "response to host defense molecules" NARROW [] +is_a: GO:0052173 ! response to defenses of other organism +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0052201 +name: response to symbiont defenses +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0009608 ! response to symbiont +is_a: GO:0052173 ! response to defenses of other organism + +[Term] +id: GO:0052202 +name: obsolete negative regulation by symbiont of defense-related host cell wall callose deposition +namespace: biological_process +alt_id: GO:0052087 +alt_id: GO:0052282 +alt_id: GO:0052311 +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. +synonym: "down regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "down-regulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "downregulation by symbiont of defense-related host cell wall callose deposition" EXACT [] +synonym: "inhibition by symbiont of defense-related host cell wall callose deposition" NARROW [] +synonym: "negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of defense-related host callose deposition" BROAD [] +is_obsolete: true + +[Term] +id: GO:0052203 +name: obsolete modulation of catalytic activity in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modulation of enzyme activity within other organism during symbiotic interaction" EXACT [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052204 +name: obsolete negative regulation of molecular function in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "down regulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "down-regulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "downregulation of protein function in other organism during symbiotic interaction" EXACT [] +synonym: "inhibition of protein function in other organism" EXACT [] +synonym: "inhibition of protein function in other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052205 +name: obsolete modulation of molecular function in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification of molecular function in other organism during symbiotic interaction" EXACT [] +synonym: "modification of protein function in other organism during symbiotic interaction" EXACT [GOC:dph, GOC:tb] +synonym: "modulation of molecular function in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052206 +name: obsolete modification of morphology or physiology of other organism via protein secreted by type II secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type II secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification of morphology or physiology of other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052207 +name: obsolete modification of morphology or physiology of other organism via protein secreted by type III secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type III secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification of morphology or physiology of other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052208 +name: obsolete modification of morphology or physiology of other organism via substance secreted by type IV secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by a type IV secretion system in the first organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification of morphology or physiology of other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052209 +name: obsolete interaction with other organism via substance secreted by type IV secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type IV secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with other organism via substance secreted by type IV secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052210 +name: obsolete interaction with other organism via protein secreted by type III secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type III secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with other organism via protein secreted by type III secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052211 +name: obsolete interaction with other organism via protein secreted by type II secretion system involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. An interaction with a second organism mediated by a substance secreted by the first organism by a type II secretion system, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with other organism via protein secreted by type II secretion system during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052212 +name: obsolete modification of morphology or physiology of other organism via secreted substance involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a second organism, mediated by a substance secreted by one of the organisms, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification of host morphology or physiology via effector molecule" NARROW [] +synonym: "modification of host morphology or physiology via ellicitor" NARROW [] +synonym: "modification of morphology or physiology of other organism via secreted substance during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052213 +name: obsolete interaction with symbiont via secreted substance +namespace: biological_process +def: "OBSOLETE. An interaction with a symbiont organism mediated by a substance secreted by a host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that this process was not clearly defined, and propably represented some immune response. . +synonym: "interaction with symbiont via secreted substance during symbiotic interaction" RELATED [GOC:dph] +synonym: "interaction with symbiont via secreted substance involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052214 +name: obsolete metabolism of substance in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "metabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052215 +name: obsolete energy taxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in the environment of a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "energy taxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052216 +name: obsolete chemotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "chemotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052217 +name: obsolete aerotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "aerotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052218 +name: obsolete positive energy taxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive energy taxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052219 +name: obsolete negative energy taxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on, within or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative energy taxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative energy taxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052220 +name: obsolete positive aerotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive aerotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052221 +name: obsolete positive chemotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive chemotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052222 +name: obsolete negative aerotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative aerotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative aerotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052223 +name: obsolete negative chemotaxis in environment of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on, within or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative chemotaxis in environment of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative chemotaxis in response to environment of other organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052224 +name: obsolete energy taxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "energy taxis within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052225 +name: obsolete energy taxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052226 +name: obsolete biosynthesis of substance in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the formation of substances, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "biosynthesis of substance in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052227 +name: obsolete catabolism of substance in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in a second organism resulting in the breakdown of substances, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism of substance in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052228 +name: obsolete metabolism by symbiont of host protein +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052229 +name: obsolete metabolism of macromolecule in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052230 +name: obsolete modulation of intracellular transport in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modulation of intracellular trafficking in other organism" EXACT [] +synonym: "modulation of intracellular transport in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052231 +name: obsolete modulation of phagocytosis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "modulation of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052232 +name: obsolete positive aerotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052233 +name: obsolete positive aerotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive aerotaxis within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052234 +name: obsolete negative aerotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052235 +name: obsolete negative aerotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative aerotaxis within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052236 +name: obsolete negative chemotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052237 +name: obsolete aerotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "aerotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "aerotaxis within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052238 +name: obsolete aerotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The movement of a motile cell or organism in response to environmental oxygen on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "aerotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052239 +name: obsolete negative chemotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative chemotaxis within other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052240 +name: obsolete positive chemotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive chemotaxis within other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052241 +name: obsolete positive chemotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism towards a higher concentration of a specific chemical on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052242 +name: obsolete chemotaxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "chemotaxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "chemotaxis within other organism during symbiotic interaction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052243 +name: obsolete chemotaxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism in response to a specific chemical concentration gradient on or near a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "chemotaxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052244 +name: obsolete negative energy taxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative energy taxis within other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052245 +name: obsolete negative energy taxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "negative energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052246 +name: obsolete positive energy taxis on or near other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism on or near a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive energy taxis on or near other organism during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052247 +name: obsolete positive energy taxis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell or organism within a second organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents both a process and a location. +synonym: "positive energy taxis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive energy taxis within other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052249 +name: obsolete modulation of RNA levels in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modulation of RNA levels in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052257 +name: obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] +comment: This term was obsoleted because it has been misused. +synonym: "general elicitor dependent induction of innate immunity of other organism" EXACT [] +synonym: "general elicitor-dependent induction of innate immunity of other organism" EXACT [] +synonym: "MAMP dependent induction of innate immunity of other organism" EXACT [] +synonym: "MAMP-dependent induction of innate immunity of other organism" EXACT [] +synonym: "PAMP dependent induction of innate immunity of other organism" EXACT [] +synonym: "PAMP-dependent induction of innate immunity of other organism" EXACT [] +synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "pathogen-associated molecular pattern dependent induction by organism of innate immunity of other organism involved in symbiotic interaction" EXACT [GOC:pg] +is_obsolete: true +consider: GO:0002221 +consider: GO:0002752 +consider: GO:0052034 + +[Term] +id: GO:0052308 +name: obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process that involves recognition of a pathogen-associated molecular pattern, and by which an organism modulates the frequency, rate or extent of the innate immune response, the first line of defense against infection, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mah] +comment: This term was obsoleted because it has been misused. +synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "pathogen-associated molecular pattern dependent modulation by organism of innate immunity in other organism involved in symbiotic interaction" EXACT [GOC:pg] +is_obsolete: true +consider: GO:0002221 +consider: GO:0002752 +consider: GO:0052034 + +[Term] +id: GO:0052312 +name: obsolete modulation of transcription in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modulation of transcription in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052313 +name: obsolete modulation of nutrient release from other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modulation of nutrient release from other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052314 +name: phytoalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] +subset: goslim_pir +synonym: "phytoalexin metabolism" EXACT [] +is_a: GO:0009404 ! toxin metabolic process + +[Term] +id: GO:0052315 +name: phytoalexin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response." [Wikipedia:Phytoalexin] +synonym: "phytoalexin biosynthesis" EXACT [] +is_a: GO:0009403 ! toxin biosynthetic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052316 +name: phytoalexin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] +synonym: "phytoalexin catabolism" EXACT [] +is_a: GO:0009407 ! toxin catabolic process +is_a: GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052317 +name: camalexin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving camalexin, an indole phytoalexin." [GOC:ai] +synonym: "camalexin metabolism" EXACT [] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046217 ! indole phytoalexin metabolic process + +[Term] +id: GO:0052318 +name: regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response." [GOC:ai] +synonym: "regulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052319 +name: regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] +synonym: "regulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052320 +name: positive regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:mtg_pamgo_17jul06] +synonym: "activation of phytoalexin metabolism" NARROW [] +synonym: "positive regulation of phytoalexin metabolism" RELATED [] +synonym: "stimulation of phytoalexin metabolism" NARROW [] +synonym: "up regulation of phytoalexin metabolism" EXACT [] +synonym: "up-regulation of phytoalexin metabolism" EXACT [] +synonym: "upregulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +relationship: positively_regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052321 +name: negative regulation of phytoalexin metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin metabolism, the chemical reactions and pathways involving phytoalexins." [GOC:ai] +synonym: "down regulation of phytoalexin metabolism" EXACT [] +synonym: "down-regulation of phytoalexin metabolism" EXACT [] +synonym: "downregulation of phytoalexin metabolism" EXACT [] +synonym: "inhibition of phytoalexin metabolism" NARROW [] +synonym: "negative regulation of phytoalexin metabolism" EXACT [] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0052318 ! regulation of phytoalexin metabolic process +relationship: negatively_regulates GO:0052314 ! phytoalexin metabolic process + +[Term] +id: GO:0052322 +name: positive regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:mtg_pamgo_17jul06] +synonym: "activation of phytoalexin biosynthesis" NARROW [] +synonym: "positive regulation of phytoalexin biosynthesis" EXACT [] +synonym: "stimulation of phytoalexin biosynthesis" NARROW [] +synonym: "up regulation of phytoalexin biosynthesis" EXACT [] +synonym: "up-regulation of phytoalexin biosynthesis" EXACT [] +synonym: "upregulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process +is_a: GO:0052320 ! positive regulation of phytoalexin metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052323 +name: negative regulation of phytoalexin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins." [GOC:ai] +synonym: "down regulation of phytoalexin biosynthesis" EXACT [] +synonym: "down-regulation of phytoalexin biosynthesis" EXACT [] +synonym: "downregulation of phytoalexin biosynthesis" EXACT [] +synonym: "inhibition of phytoalexin biosynthesis" NARROW [] +synonym: "negative regulation of phytoalexin biosynthesis" EXACT [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process +is_a: GO:0052321 ! negative regulation of phytoalexin metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0052315 ! phytoalexin biosynthetic process + +[Term] +id: GO:0052324 +name: plant-type cell wall cellulose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall cellulose biosynthesis" EXACT [] +synonym: "cellulose biosynthesis during cell wall biosynthesis" RELATED [] +is_a: GO:0030244 ! cellulose biosynthetic process +is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process +is_a: GO:0052541 ! plant-type cell wall cellulose metabolic process +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0052325 +name: cell wall pectin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall pectin biosynthesis" EXACT [] +synonym: "pectin biosynthesis during cell wall organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045489 ! pectin biosynthetic process +is_a: GO:0052546 ! cell wall pectin metabolic process +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0052326 +name: obsolete interaction with symbiont via protein secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type IV secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "interaction with symbiont via protein secreted by type IV secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052327 +name: obsolete interaction with symbiont via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type II secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "interaction with symbiont via protein secreted by type II secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052328 +name: obsolete interaction with symbiont via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the symbiont organism mediated by a substance secreted by the other organism by a type III secretion system. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "interaction with symbiont via protein secreted by type III secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052331 +name: obsolete hemolysis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "haemolysis in other organism involved in symbiotic interaction" EXACT [] +synonym: "hemolysin activity" RELATED [] +synonym: "hemolysis by organism of erythrocytes in other organism during symbiotic interaction" RELATED [] +synonym: "hemolysis by organism of RBCs in other organism during symbiotic interaction" RELATED [CL:0000232] +synonym: "hemolysis by organism of red blood cells in other organism during symbiotic interaction" RELATED [CL:0000232] +synonym: "hemolysis of cells in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "hemolysis of cells in other organism involved in symbiotic interaction" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0052332 +name: obsolete modification by organism of membrane in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification by organism of cell membrane in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "modification by organism of cell membrane in other organism involved in symbiotic interaction" NARROW [GOC:bf, GOC:jl] +is_obsolete: true + +[Term] +id: GO:0052333 +name: obsolete modification by organism of cell wall of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of cell wall of other organism" RELATED [] +synonym: "modification by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052334 +name: obsolete modification by organism of cytoskeleton of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "modification by organism of cytoskeleton of other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052335 +name: modification by host of symbiont cytoskeleton +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052187 ! modification by host of symbiont cellular component + +[Term] +id: GO:0052336 +name: modification by host of symbiont cell wall +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "metabolism of symbiont cell wall by organism" EXACT [] +is_a: GO:0052187 ! modification by host of symbiont cellular component + +[Term] +id: GO:0052337 +name: modification by host of symbiont membrane +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a symbiont cellular membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modification by host of symbiont cell membrane" NARROW [GOC:bf, GOC:jl] +is_a: GO:0052187 ! modification by host of symbiont cellular component + +[Term] +id: GO:0052338 +name: disruption by host of symbiont cell wall +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism of symbiont cell wall by organism" EXACT [] +synonym: "degradation of symbiont cell wall by organism" EXACT [] +synonym: "disassembly by host of symbiont cell wall" EXACT [] +is_a: GO:0052336 ! modification by host of symbiont cell wall + +[Term] +id: GO:0052339 +name: obsolete disruption by organism of cell wall of other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "disassembly by organism of cell wall of other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052340 +name: obsolete catabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052341 +name: obsolete catabolism by organism of cell wall pectin in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of cell wall pectin in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052342 +name: obsolete catabolism by organism of cell wall chitin in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052343 +name: obsolete positive regulation by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont phytoalexin production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052344 +name: positive regulation by symbiont of host phytoalexin production +namespace: biological_process +alt_id: GO:0052329 +def: "Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host phytoalexin production" NARROW [] +synonym: "positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction" BROAD [] +synonym: "stimulation by symbiont of host phytoalexin production" NARROW [] +synonym: "up regulation by symbiont of host phytoalexin production" EXACT [] +synonym: "up-regulation by symbiont of host phytoalexin production" EXACT [] +synonym: "upregulation by symbiont of host phytoalexin production" EXACT [] +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052346 +name: obsolete positive regulation by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont nitric oxide production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052349 +name: obsolete positive regulation by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont reactive oxygen species production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052350 +name: obsolete induction by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates induced systemic resistance in the symbiont; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of induced systemic resistance in symbiont" EXACT [] +synonym: "activation by organism of ISR in symbiont" EXACT [] +synonym: "induction by organism of induced systemic resistance in symbiont" EXACT [] +synonym: "induction by organism of ISR in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052351 +name: obsolete induction by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of SAR in symbiont" EXACT [] +synonym: "activation by organism of systemic acquired resistance in symbiont" EXACT [] +synonym: "induction by organism of SAR in symbiont" EXACT [] +synonym: "induction by organism of systemic acquired resistance in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052352 +name: obsolete biosynthesis by host of substance in symbiont +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the formation of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0052353 +name: obsolete catabolism by host of symbiont carbohydrate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052354 +name: obsolete catabolism by organism of carbohydrate in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of carbohydrate molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +synonym: "catabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052355 +name: obsolete catabolism by host of symbiont cell wall cellulose +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellulose in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052356 +name: obsolete catabolism by host of symbiont cell wall chitin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of chitin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [PMID:11085997] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052357 +name: obsolete catabolism by host of symbiont cell wall pectin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of pectin in the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence it exists. +is_obsolete: true + +[Term] +id: GO:0052358 +name: obsolete catabolism by host of symbiont glucan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence it exists. +is_obsolete: true + +[Term] +id: GO:0052359 +name: obsolete catabolism by organism of glucan in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of glucan molecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052360 +name: obsolete catabolism by host of symbiont macromolecule +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052361 +name: obsolete catabolism by organism of macromolecule in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of macromolecule in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052362 +name: obsolete catabolism by host of symbiont protein +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052363 +name: obsolete catabolism by organism of protein in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052364 +name: obsolete catabolism by host of substance in symbiont +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont resulting in the breakdown of substances. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052365 +name: obsolete catabolism by host of symbiont xylan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because there is no evidence it exists. +is_obsolete: true + +[Term] +id: GO:0052366 +name: obsolete catabolism by organism of xylan in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052367 +name: disruption by host of symbiont cellular component +namespace: biological_process +def: "The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +synonym: "catabolism of symbiont cellular component by organism" EXACT [] +synonym: "catabolism of symbiont structural constituent by organism" EXACT [] +synonym: "degradation of symbiont cellular component by organism" EXACT [] +synonym: "disassembly by host of symbiont cellular component" RELATED [] +is_a: GO:0052187 ! modification by host of symbiont cellular component + +[Term] +id: GO:0052368 +name: obsolete disruption by organism of cellular component in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction." [ISBN:0198547684] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "catabolism of cellular component in other organism" EXACT [] +synonym: "catabolism of structural constituent in other organism" EXACT [] +synonym: "degradation of cellular component in other organism" EXACT [] +synonym: "disassembly by organism of cellular component in other organism during symbiotic interaction" RELATED [GOC:dph] +synonym: "disassembly by organism of cellular component in other organism involved in symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052372 +name: modulation by symbiont of entry into host +namespace: biological_process +alt_id: GO:0052371 +def: "Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "regulation by organism of entry into other organism involved in symbiotic interaction" RELATED [] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +relationship: regulates GO:0044409 ! entry into host + +[Term] +id: GO:0052373 +name: suppression of symbiont entry into host +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "down-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "downregulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "inhibition by organism of entry into other organism during symbiotic interaction" NARROW [] +synonym: "negative regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "negative regulation by organism of entry into other organism involved in symbiotic interaction" BROAD [] +synonym: "suppression of symbiont entry into host by host" EXACT [] +is_a: GO:0140546 ! defense response to symbiont + +[Term] +id: GO:0052374 +name: obsolete negative regulation by symbiont of entry into host +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "down regulation by symbiont of entry into host" EXACT [] +synonym: "down-regulation by symbiont of entry into host" EXACT [] +synonym: "downregulation by symbiont of entry into host" EXACT [] +synonym: "inhibition by symbiont of entry into host" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052375 +name: obsolete evasion or tolerance by organism of symbiont-produced nitric oxide +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of nitric oxide produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion or tolerance by organism of symbiont nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of symbiont NO" EXACT [] +synonym: "evasion or tolerance by organism of symbiont-produced nitric oxide" EXACT [] +synonym: "evasion or tolerance by organism of symbiont-produced NO" EXACT [] +synonym: "evasion or tolerance of nitric oxide produced by symbiont in response to organism" EXACT [] +synonym: "evasion or tolerance of NO produced by symbiont in response to organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052377 +name: obsolete evasion or tolerance by organism of symbiont-produced phytoalexins +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of phytoalexins produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion or tolerance by organism of symbiont phytoalexins" EXACT [] +synonym: "evasion or tolerance by organism of symbiont-produced phytoalexins" EXACT [] +synonym: "evasion or tolerance of phytoalexins produced by symbiont in response to organism" EXACT [] +synonym: "symbiont phytoalexin detoxification" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052379 +name: obsolete modulation by organism of entry into other organism via phagocytosis involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent to which it enters into a second organism via the phagocytotic processes of the other organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "modulation by organism of entry into other organism via other organism phagocytosis during symbiotic interaction" RELATED [] +synonym: "modulation by organism of entry into other organism via phagocytosis during symbiotic interaction" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052381 +name: tRNA dimethylallyltransferase activity +namespace: molecular_function +alt_id: GO:0004811 +def: "Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine." [EC:2.5.1.75] +comment: Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC:2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate. +synonym: "dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity" EXACT systematic_synonym [EC:2.5.1.75] +synonym: "tRNA isopentenyltransferase activity" RELATED [GOC:mah, GOC:vw] +synonym: "tRNA prenyltransferase activity" BROAD [EC:2.5.1.75] +xref: EC:2.5.1.75 +xref: MetaCyc:RXN0-6274 +xref: Reactome:R-HSA-6784462 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs" +xref: Reactome:R-HSA-6787567 "TRIT1 transfers dimethylallyl group to adenosine-37 of tRNA(Ser)" +xref: RHEA:26482 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0052383 +name: obsolete induction by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont innate immune response" EXACT [] +synonym: "activation by organism of symbiont innate immunity" EXACT [] +synonym: "induction by organism of symbiont innate immune response" EXACT [] +synonym: "induction by organism of symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052384 +name: obsolete evasion or tolerance by organism of symbiont-produced reactive oxygen species +namespace: biological_process +def: "OBSOLETE. The process by which an organism avoids the effects of reactive oxygen species produced as a defense response by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "evasion by organism of cellular damage caused by symbiont oxidative burst" NARROW [] +synonym: "evasion or tolerance by organism of reactive oxygen species produced during symbiont defense response" EXACT [] +synonym: "evasion or tolerance by organism of symbiont-produced reactive oxygen species" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont metabolic burst" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont oxidative burst" EXACT [] +synonym: "evasion or tolerance of defense-related symbiont respiratory burst" EXACT [] +synonym: "evasion or tolerance of reactive oxygen species produced by symbiont in response to organism" EXACT [] +synonym: "evasion or tolerance of symbiont-produced active oxygen species" EXACT [] +synonym: "evasion or tolerance of symbiont-produced AOS" EXACT [] +synonym: "evasion or tolerance of symbiont-produced reactive oxygen intermediates" EXACT [] +synonym: "evasion or tolerance of symbiont-produced ROIs" EXACT [] +synonym: "evasion or tolerance of symbiont-produced ROS" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052386 +name: cell wall thickening +namespace: biological_process +def: "A type of cell wall modification in which the cell wall is reinforced and made thicker." [GOC:mtg_pamgo_17jul06] +is_a: GO:0042545 ! cell wall modification + +[Term] +id: GO:0052387 +name: obsolete induction by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont apoptosis" EXACT [] +synonym: "activation by organism of symbiont apoptotic programmed cell death" EXACT [] +synonym: "induction by organism of symbiont apoptosis" EXACT [] +synonym: "induction by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052390 +name: induction by symbiont of host innate immune response +namespace: biological_process +alt_id: GO:0052166 +alt_id: GO:0052305 +alt_id: GO:0052382 +def: "The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of host innate immune response" EXACT [] +synonym: "activation by organism of host innate immunity" EXACT [] +synonym: "activation by symbiont of host innate immunity" EXACT [] +synonym: "induction by organism of host innate immune response" RELATED [] +synonym: "induction by organism of innate immune response in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by symbiont of host innate immunity" EXACT [] +synonym: "induction of host innate immunity" EXACT [] +synonym: "positive regulation by symbiont of host innate immune response" RELATED [] +synonym: "positive regulation by symbiont of host innate immunity" RELATED [] +synonym: "positive regulation of host innate immune response" RELATED [] +synonym: "positive regulation of innate immune response in other organism" BROAD [] +synonym: "stimulation by symbiont of host innate immunity" RELATED [] +synonym: "up regulation by symbiont of host innate immunity" RELATED [] +synonym: "up-regulation by symbiont of host innate immunity" RELATED [] +synonym: "upregulation by symbiont of host innate immunity" EXACT [] +is_a: GO:0052559 ! induction by symbiont of host immune response + +[Term] +id: GO:0052391 +name: induction by symbiont of defense-related host calcium ion flux +namespace: biological_process +alt_id: GO:0052065 +alt_id: GO:0052265 +alt_id: GO:0052389 +def: "The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by organism of host Ca2+ flux" EXACT [] +synonym: "activation by organism of host calcium ion flux" EXACT [] +synonym: "activation by symbiont of defense-related host calcium ion flux" EXACT [] +synonym: "induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by organism of host Ca2+ flux" EXACT [] +synonym: "positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of defense-related host Ca2+ flux" RELATED [] +synonym: "positive regulation by symbiont of defense-related host calcium ion flux" RELATED [] +synonym: "stimulation by symbiont of defense-related host calcium ion flux" RELATED [] +synonym: "up regulation by symbiont of defense-related host calcium ion flux" RELATED [] +synonym: "up-regulation by symbiont of defense-related host calcium ion flux" RELATED [] +synonym: "upregulation by symbiont of defense-related host calcium ion flux" RELATED [] +is_a: GO:0044416 ! induction by symbiont of host defense response +is_a: GO:0052162 ! modulation by symbiont of defense-related host calcium ion flux + +[Term] +id: GO:0052392 +name: obsolete induction by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont Ca2+ flux" EXACT [] +synonym: "activation by organism of symbiont calcium ion flux" EXACT [] +synonym: "induction by organism of defense-related symbiont calcium ion flux" EXACT [] +synonym: "induction by organism of symbiont Ca2+ flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052393 +name: obsolete induction by host of symbiont defense response +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's defense response. +synonym: "activation of symbiont defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052394 +name: obsolete induction by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont defense-related cell wall thickening" EXACT [] +synonym: "activation by organism of symbiont defensive cell wall thickening" EXACT [] +synonym: "induction by organism of defense-related symbiont cell wall thickening" EXACT [] +synonym: "induction by organism of symbiont defensive cell wall thickening" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052395 +name: obsolete induction by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont nitric acid production" EXACT [] +synonym: "activation by organism of defense-related symbiont NO production" EXACT [] +synonym: "induction by organism of defense-related symbiont nitric oxide production" EXACT [] +synonym: "induction by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052396 +name: obsolete induction by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont non-apoptotic programmed cell death" EXACT [] +synonym: "induction by organism of symbiont non-apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052398 +name: obsolete induction by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont phytoalexin production" EXACT [] +synonym: "induction by organism of symbiont phytoalexin production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052399 +name: obsolete induction by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. The activation by an organism of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont programmed cell death" EXACT [] +synonym: "induction by organism of symbiont programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052401 +name: obsolete induction by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "activation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "activation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "activation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "activation by organism of defense-related symbiont reactive oxygen species production" EXACT [] +synonym: "activation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "activation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "activation by organism of defense-related symbiont ROS production" EXACT [] +synonym: "induction by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "induction by organism of defense-related symbiont AOS production" EXACT [] +synonym: "induction by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "induction by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "induction by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "induction by organism of defense-related symbiont reactive oxygen species production" EXACT [] +synonym: "induction by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "induction by organism of defense-related symbiont ROI production" EXACT [] +synonym: "induction by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052402 +name: obsolete induction by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. The activation by an organism of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "activation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "activation by organism of symbiont gene-for-gene resistance" EXACT [] +synonym: "activation by organism of symbiont resistance gene-dependent defense response" EXACT [] +synonym: "induction by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "induction by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "induction by organism of symbiont gene-for-gene resistance" EXACT [] +synonym: "induction by organism of symbiont resistance gene-dependent defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052403 +name: negative regulation by host of symbiont catalytic activity +namespace: biological_process +alt_id: GO:0052405 +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by host of symbiont enzyme activity" EXACT [] +synonym: "down regulation by host of symbiont protein function" BROAD [] +synonym: "down-regulation by host of symbiont enzyme activity" EXACT [] +synonym: "down-regulation by host of symbiont protein function" BROAD [] +synonym: "downregulation by host of symbiont enzyme activity" EXACT [] +synonym: "downregulation by host of symbiont protein function" BROAD [] +synonym: "inhibition by host of symbiont enzyme activity" NARROW [] +synonym: "inhibition by host of symbiont protein function" NARROW [] +synonym: "inhibition of symbiont enzyme activity" EXACT [] +synonym: "inhibition of symbiont protein function" BROAD [] +synonym: "negative regulation by host of symbiont enzyme activity" EXACT [] +synonym: "negative regulation by host of symbiont molecular function" BROAD [] +is_a: GO:0052422 ! modulation by host of symbiont catalytic activity + +[Term] +id: GO:0052404 +name: obsolete negative regulation by host of symbiont peptidase activity +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont protease activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:mtg_pamgo_17jul06, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation by host of symbiont protease activity" NARROW [] +synonym: "down-regulation by host of symbiont protease activity" NARROW [] +synonym: "downregulation by host of symbiont protease activity" NARROW [] +synonym: "inhibition by host of symbiont protease activity" NARROW [] +synonym: "inhibition of symbiont protease activity" NARROW [] +synonym: "negative regulation by host of symbiont protease activity" NARROW [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0052406 +name: obsolete metabolism by host of symbiont carbohydrate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052407 +name: obsolete metabolism by organism of carbohydrate in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving carbohydrates within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of carbohydrate in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052408 +name: obsolete metabolism by host of symbiont cell wall cellulose +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052409 +name: obsolete metabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving cellulose in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of cell wall cellulose in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052410 +name: obsolete metabolism by host of symbiont cell wall chitin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052411 +name: obsolete metabolism by organism of cell wall chitin in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving chitin in the cell wall of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of cell wall chitin in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052412 +name: obsolete metabolism by host of symbiont cell wall pectin +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence it exists. +is_obsolete: true + +[Term] +id: GO:0052414 +name: obsolete metabolism by host of symbiont glucan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052415 +name: obsolete metabolism by organism of glucan in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving glucans within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of glucan in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052416 +name: obsolete metabolism by host of symbiont macromolecule +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052417 +name: obsolete metabolism by host of symbiont protein +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052418 +name: obsolete metabolism by organism of protein in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving protein macromolecules within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "metabolism by organism of protein in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052419 +name: obsolete metabolism by host of substance in symbiont +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0052420 +name: obsolete metabolism by host of symbiont xylan +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence it exists. +is_obsolete: true + +[Term] +id: GO:0052421 +name: obsolete metabolism by organism of xylan in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways performed by an organism involving xylan within a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was deprecated because it represents an unnecessary grouping class. +synonym: "metabolism by organism of xylan in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052422 +name: modulation by host of symbiont catalytic activity +namespace: biological_process +alt_id: GO:0052428 +def: "The process in which a host organism effects a change in the enzyme activity of its symbiont organism." [GOC:mtg_pamgo_17jul06, GOC:tb] +synonym: "modulation by host of symbiont enzyme activity" EXACT [GOC:tb] +synonym: "modulation by host of symbiont molecular function" BROAD [] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0052424 +name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type III secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type III secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052425 +name: obsolete modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type II secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modification by organism of symbiont morphology or physiology via protein secreted by type II secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052426 +name: obsolete modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system +namespace: biological_process +def: "OBSOLETE. The process by which an organism effects a change in the structure or function of its symbiont organism, mediated by a substance secreted by a type IV secretion system in the organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modification by organism of symbiont morphology or physiology via substance secreted by type IV secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052427 +name: obsolete modulation by host of symbiont peptidase activity +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in symbiont peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents a molecular function. +synonym: "modulation by host of symbiont protease activity" NARROW [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0052429 +name: obsolete modulation by organism of symbiont B-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the B-cell mediated immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont B-cell mediated immune response" EXACT [] +synonym: "regulation by organism of symbiont B-cell mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052430 +name: modulation by host of symbiont RNA levels +namespace: biological_process +def: "The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0052431 +name: obsolete modulation by organism of symbiont T-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of a symbiont organism, where the two organisms are in a symbiotic interaction. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont T-cell mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052432 +name: obsolete modulation by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont apoptosis" EXACT [] +synonym: "modulation by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052434 +name: obsolete modulation by organism of symbiont cell-mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of any form of cell-based immune response of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont cell-based immune response" EXACT [] +synonym: "modulation by organism of symbiont cell-mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052435 +name: obsolete modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "modulation of defense-related symbiont MAPK-mediated signal transduction pathway by organism" EXACT [] +synonym: "modulation of defense-related symbiont mitogen activated protein kinase-mediated signal transduction pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052436 +name: obsolete modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the symbiont calcium-dependent protein kinase signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT [] +synonym: "modulation by organism of defense-related symbiont CDPK pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052437 +name: obsolete modulation by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont Ca2+ flux" EXACT [] +synonym: "modulation by organism of defense-related symbiont calcium ion flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052438 +name: obsolete modulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052439 +name: obsolete modulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052440 +name: obsolete modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052442 +name: obsolete modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "modulation of defense-related symbiont JA-mediated signal transduction pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052444 +name: obsolete modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "modulation of defense-related symbiont SA-mediated signal transduction pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052446 +name: obsolete modulation by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont cell wall thickening" EXACT [] +synonym: "modulation by organism of symbiont defensive cell wall thickening" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052447 +name: obsolete modulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont ethylene-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052448 +name: obsolete modulation by organism of ethylene levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of ethylene in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of ethylene levels in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052450 +name: obsolete modulation by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of induced systemic resistance in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052451 +name: obsolete modulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont inflammatory response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052452 +name: obsolete modulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont innate immunity" EXACT [] +synonym: "modulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052453 +name: obsolete modulation by organism of symbiont intracellular transport +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont intracellular transport" EXACT [] +synonym: "modulation of symbiont intracellular trafficking" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052454 +name: obsolete modulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont JA-mediated defense response" EXACT [] +synonym: "modulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052455 +name: obsolete modulation by organism of jasmonic acid levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of jasmonic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of jasmonic acid levels in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052457 +name: obsolete modulation by organism of defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of nitric oxide as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont nitric oxide production" EXACT [] +synonym: "modulation by organism of defense-related symbiont NO production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052458 +name: obsolete modulation by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont non-apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052460 +name: modulation of nutrient release by symbiont +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by host of nutrient release from symbiont" EXACT [] +is_a: GO:0051851 ! modulation by host of symbiont process +relationship: part_of GO:0051850 ! acquisition of nutrients from symbiont + +[Term] +id: GO:0052461 +name: obsolete modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052462 +name: obsolete modulation by host of symbiont phagocytosis +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0052463 +name: obsolete modulation by organism of symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont phytoalexin production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052464 +name: obsolete modulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont programmed cell death" EXACT [] +synonym: "modulation of symbiont HR" BROAD [] +synonym: "modulation of symbiont hypersensitive response" NARROW [] +synonym: "modulation of symbiont PCD" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052465 +name: obsolete modulation by organism of defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense-related symbiont active oxygen species production" EXACT [] +synonym: "modulation by organism of defense-related symbiont AOS production" EXACT [] +synonym: "modulation by organism of defense-related symbiont metabolic burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont oxidative burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont reactive oxidative species production" EXACT [] +synonym: "modulation by organism of defense-related symbiont reactive oxygen intermediate production" EXACT [] +synonym: "modulation by organism of defense-related symbiont reactive oxygen species production" EXACT [] +synonym: "modulation by organism of defense-related symbiont respiratory burst" EXACT [] +synonym: "modulation by organism of defense-related symbiont ROI production" EXACT [] +synonym: "modulation by organism of defense-related symbiont ROS production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052466 +name: obsolete modulation by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "modulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "modulation by organism of symbiont gene-for-gene resistance" EXACT [] +synonym: "modulation by organism of symbiont resistance gene-dependent defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052467 +name: obsolete modulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont SA-mediated defense response" EXACT [] +synonym: "modulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052468 +name: obsolete modulation by organism of salicylic acid levels in symbiont +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of the levels of salicylic acid in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of salicylic acid levels in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052470 +name: obsolete modulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0052471 +name: obsolete modulation by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of systemic acquired resistance in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052472 +name: modulation by host of symbiont transcription +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription." [GOC:mtg_pamgo_17jul06] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0052473 +name: obsolete negative regulation by organism of symbiont B-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont B-cell mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052474 +name: obsolete negative regulation by organism of symbiont T-cell mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont T-cell mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052475 +name: obsolete negative regulation by organism of symbiont cell-mediated immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont cell-based immune response" EXACT [] +synonym: "negative regulation by organism of symbiont cell-mediated immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052476 +name: obsolete negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +synonym: "negative regulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "suppression by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052477 +name: obsolete negative regulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of callose deposition performed by the symbiont as part of its defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of defense-related symbiont callose deposition" EXACT [] +synonym: "suppression by organism of defense-related symbiont callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052478 +name: obsolete negative regulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a valid biological process that occurs in nature. +synonym: "negative regulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052479 +name: obsolete negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] +synonym: "suppression by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052480 +name: obsolete negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of defense-related symbiont JA-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052481 +name: obsolete negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative modulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +synonym: "negative modulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +synonym: "negative regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052482 +name: defense response by cell wall thickening +namespace: biological_process +def: "A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism." [GOC:mtg_pamgo_17jul06] +synonym: "cell wall thickening during defense response" RELATED [GOC:dph] +is_a: GO:0006952 ! defense response +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0052386 ! cell wall thickening + +[Term] +id: GO:0052484 +name: obsolete negative regulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont ethylene-mediated defense response" EXACT [] +synonym: "suppression by organism of symbiont ethylene-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052485 +name: obsolete negative regulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont inflammatory response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052486 +name: obsolete negative regulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the symbiont organism, the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont innate immunity" EXACT [] +synonym: "negative regulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052487 +name: obsolete negative regulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] +synonym: "suppression by organism of symbiont JA-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052488 +name: obsolete negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] +synonym: "suppression of general elicitor induced symbiont innate immunity" EXACT [] +synonym: "suppression of general elicitor-induced symbiont innate immunity" EXACT [] +synonym: "suppression of MAMP induced symbiont innate immunity" EXACT [] +synonym: "suppression of MAMP-induced symbiont innate immunity" EXACT [] +synonym: "suppression of PAMP induced symbiont innate immunity" EXACT [] +synonym: "suppression of PAMP-induced symbiont innate immunity" EXACT [] +synonym: "suppression of pathogen-associated molecular pattern-induced symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052489 +name: negative regulation by host of symbiont programmed cell death +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by host of symbiont programmed cell death" EXACT [] +synonym: "down-regulation by host of symbiont programmed cell death" EXACT [] +synonym: "downregulation by host of symbiont programmed cell death" EXACT [] +synonym: "inhibition by host of symbiont programmed cell death" NARROW [] +synonym: "inhibition of symbiont programmed cell death" EXACT [] +is_a: GO:0051711 ! negative regulation of killing of cells of another organism + +[Term] +id: GO:0052491 +name: obsolete negative regulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] +synonym: "negative regulation of symbiont SA-mediated defense response" EXACT [] +synonym: "suppression by organism of symbiont salicylic acid-mediated defense response" EXACT [] +synonym: "suppression of symbiont SA mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052492 +name: obsolete negative regulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "down regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "down-regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "downregulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "inhibition by host of symbiont signal transduction pathway" NARROW [] +synonym: "negative modulation by organism of symbiont signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052494 +name: occlusion by host of symbiont vascular system +namespace: biological_process +def: "The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +is_a: GO:0052183 ! modification by host of symbiont structure + +[Term] +id: GO:0052495 +name: obsolete occlusion by organism of vascular system in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, http://www.thefreedictionary.com] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "occlusion by organism of vascular system in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052496 +name: occlusion by host of symbiont xylem +namespace: biological_process +def: "The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +is_a: GO:0052494 ! occlusion by host of symbiont vascular system + +[Term] +id: GO:0052497 +name: obsolete occlusion by organism of xylem in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "occlusion by organism of xylem in other organism during symbiotic interaction" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0052498 +name: obsolete pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "general elicitor-dependent activation of symbiont innate immunity" EXACT [] +synonym: "general elicitor-dependent induction of symbiont innate immunity" EXACT [] +synonym: "MAMP dependent activation of symbiont innate immunity" EXACT [] +synonym: "MAMP dependent induction of symbiont innate immunity" EXACT [] +synonym: "PAMP dependent activation of symbiont innate immunity" EXACT [] +synonym: "PAMP dependent induction of symbiont innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent activation by organism of symbiont innate immunity" EXACT [] +synonym: "pathogen-associated molecular pattern dependent induction by organism of symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052499 +name: obsolete pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "pathogen-associated molecular pattern dependent modulation by organism of symbiont innate immunity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052500 +name: obsolete positive regulation by organism of symbiont apoptosis +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by apoptosis. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont apoptosis" EXACT [] +synonym: "positive regulation by organism of symbiont apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052502 +name: obsolete positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "activation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont MAPK-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont mitogen-activated protein kinase-mediated signal transduction pathway" EXACT [] +synonym: "stimulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +synonym: "up regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "up-regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont MAP kinase-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052503 +name: obsolete positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the symbiont calcium-dependent protein kinase pathway during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont calcium-dependent protein kinase pathway" EXACT [] +synonym: "positive regulation of defense-related symbiont CDPK pathway by organism" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052504 +name: obsolete positive regulation by organism of defense-related symbiont callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of callose deposition by the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of defense-related papilla formation in symbiont" NARROW [] +synonym: "induction by organism of defense-related symbiont callose deposition" NARROW [] +synonym: "positive regulation by organism of defense-related papilla formation in symbiont" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052505 +name: obsolete positive regulation by organism of defense-related symbiont cell wall callose deposition +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the symbiont in its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of defense-related symbiont cell wall callose deposition" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont cell wall callose deposition" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052506 +name: obsolete positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont ethylene-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont ethylene-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052507 +name: obsolete positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont jasmonic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont jasmonic acid-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052508 +name: obsolete positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont salicylic acid-mediated signal transduction pathways during the symbiont defense response. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "activation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "induction by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "positive regulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" EXACT [] +synonym: "upregulation by organism of defense-related symbiont SA-mediated signal transduction pathway" NARROW [] +synonym: "upregulation by organism of defense-related symbiont salicylic acid-mediated signal transduction pathway" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052511 +name: obsolete positive regulation by organism of symbiont ethylene-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "activation by organism of symbiont ethylene-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont ethylene-mediated defense response" NARROW [] +synonym: "positive regulation by organism of symbiont ethylene-mediated defense response" EXACT [] +synonym: "upregulation by organism of symbiont ethylene-mediated defense response" NARROW [] +is_obsolete: true + +[Term] +id: GO:0052512 +name: obsolete positive regulation by organism of hormone or growth regulator levels in symbiont +namespace: biological_process +def: "OBSOLETE. The increase by an organism of the levels of hormones or growth regulators in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive modulation of hormone or growth regulator levels in symbiont" EXACT [] +synonym: "positive regulation by organism of hormone or growth regulator levels in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052514 +name: obsolete positive regulation by organism of symbiont inflammatory response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the inflammatory response of a symbiont organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont inflammatory response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052515 +name: obsolete positive regulation by organism of symbiont innate immunity +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the innate immune response of the symbiont organism; the innate immune response is the symbiont's first line of defense against infection. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont innate immunity" EXACT [] +synonym: "positive regulation of symbiont innate immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052516 +name: obsolete positive regulation by organism of symbiont jasmonic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of symbiont JA-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont jasmonic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of symbiont JA-mediated defense response" EXACT [] +synonym: "positive regulation by organism of symbiont jasmonic acid-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052517 +name: obsolete positive regulation by organism of symbiont non-apoptotic programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont, where programmed cell death proceeds by a non-apoptotic pathway. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont non-apoptotic programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052519 +name: positive regulation of nutrient release by symbiont +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by host of nutrient release from symbiont" NARROW [] +synonym: "positive regulation by host of nutrient release from symbiont" EXACT [] +synonym: "promotion of nutrient release from symbiont" EXACT [] +synonym: "stimulation by host of nutrient release from symbiont" NARROW [] +synonym: "up regulation by host of nutrient release from symbiont" EXACT [] +synonym: "up-regulation by host of nutrient release from symbiont" EXACT [] +synonym: "upregulation by host of nutrient release from symbiont" EXACT [] +is_a: GO:0052460 ! modulation of nutrient release by symbiont + +[Term] +id: GO:0052520 +name: obsolete positive regulation by organism of nutrient release from other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because it represents an unnecessary grouping class. +synonym: "activation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "promotion of nutrient release from other organism" EXACT [] +synonym: "stimulation by organism of nutrient release from other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] +synonym: "up-regulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] +synonym: "upregulation by organism of nutrient release from other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052521 +name: obsolete positive regulation by host of symbiont phagocytosis +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "activation by host of symbiont phagocytosis" NARROW [] +synonym: "stimulation by host of symbiont phagocytosis" NARROW [] +synonym: "up regulation by host of symbiont phagocytosis" EXACT [] +synonym: "up-regulation by host of symbiont phagocytosis" EXACT [] +synonym: "upregulation by host of symbiont phagocytosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052522 +name: obsolete positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of phagocytosis, the engulfing by phagocytes of external particulate material, in the second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "activation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] +synonym: "positive regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "stimulation by organism of phagocytosis in other organism during symbiotic interaction" NARROW [] +synonym: "up regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] +synonym: "up-regulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] +synonym: "upregulation by organism of phagocytosis in other organism during symbiotic interaction" RELATED [] +is_obsolete: true + +[Term] +id: GO:0052523 +name: obsolete positive regulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "enhancement or induction of symbiont programmed cell death" EXACT [] +synonym: "positive regulation by organism of symbiont programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052524 +name: obsolete positive regulation by organism of symbiont salicylic acid-mediated defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of symbiont SA-mediated defense response" NARROW [] +synonym: "induction by organism of symbiont salicylic acid-mediated defense response" NARROW [] +synonym: "positive regulation by organism of symbiont SA-mediated defense response" EXACT [] +synonym: "positive regulation by organism of symbiont salicylic acid-mediated defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052525 +name: obsolete positive regulation by host of symbiont signal transduction pathway +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "activation by host of symbiont signal transduction pathway" NARROW [] +synonym: "stimulation by host of symbiont signal transduction pathway" NARROW [] +synonym: "up regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "up-regulation by host of symbiont signal transduction pathway" EXACT [] +synonym: "upregulation by host of symbiont signal transduction pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052528 +name: obsolete upregulation by organism of symbiont programmed cell death +namespace: biological_process +def: "OBSOLETE. Any process by which an organism increases the frequency, rate or extent of programmed cell death in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "enhancement of symbiont programmed cell death by organism" EXACT [] +synonym: "upregulation by organism of symbiont programmed cell death" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052530 +name: obsolete positive regulation by organism of symbiont resistance gene-dependent defense response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the resistance gene-dependent defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense response in symbiont by specific elicitors" EXACT [] +synonym: "positive regulation by organism of pathogen-race/symbiont plant cultivar-specific resistance in symbiont" EXACT [] +synonym: "positive regulation by organism of symbiont gene-for-gene resistance" EXACT [] +synonym: "positive regulation by organism of symbiont resistance gene-dependent defense response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052531 +name: obsolete positive regulation by organism of defense-related symbiont calcium ion flux +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of fluxes of calcium ions that occur as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont Ca2+ flux" EXACT [] +synonym: "positive regulation by organism of defense-related symbiont calcium ion flux" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052534 +name: obsolete positive regulation by organism of induced systemic resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the symbiont organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of induced systemic resistance in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052536 +name: obsolete positive regulation by organism of systemic acquired resistance in symbiont +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of systemic acquired resistance in the symbiont organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of systemic acquired resistance in symbiont" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052540 +name: obsolete positive regulation by organism of defense-related symbiont cell wall thickening +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of symbiont processes resulting in the thickening of its cell walls, occurring as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of defense-related symbiont cell wall thickening" EXACT [] +synonym: "positive regulation by organism of symbiont defensive cell wall thickening" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052541 +name: plant-type cell wall cellulose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall." [GOC:mah, ISBN:0198506732] +synonym: "cell wall cellulose metabolism" EXACT [] +synonym: "cellulose and pectin-containing cell wall cellulose metabolic process" EXACT [] +is_a: GO:0030243 ! cellulose metabolic process +is_a: GO:0034406 ! cell wall beta-glucan metabolic process +relationship: part_of GO:0009664 ! plant-type cell wall organization + +[Term] +id: GO:0052542 +name: defense response by callose deposition +namespace: biological_process +def: "Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose deposition during defense response" RELATED [GOC:dph] +synonym: "callose localization during defense response" RELATED [] +is_a: GO:0006952 ! defense response +is_a: GO:0052545 ! callose localization + +[Term] +id: GO:0052543 +name: callose deposition in cell wall +namespace: biological_process +def: "Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose localization in cell wall" EXACT [] +synonym: "cell wall callose deposition" EXACT [] +synonym: "cell wall callose localization" EXACT [] +is_a: GO:0052386 ! cell wall thickening +is_a: GO:0052545 ! callose localization +is_a: GO:0070727 ! cellular macromolecule localization + +[Term] +id: GO:0052544 +name: defense response by callose deposition in cell wall +namespace: biological_process +def: "Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06] +synonym: "callose deposition in cell wall during defense response" RELATED [GOC:dph] +synonym: "callose localization in cell wall during defense response" EXACT [] +synonym: "cell wall callose deposition during defense response" EXACT [] +synonym: "cell wall callose localization during defense response" EXACT [] +is_a: GO:0052482 ! defense response by cell wall thickening +is_a: GO:0052542 ! defense response by callose deposition +is_a: GO:0052543 ! callose deposition in cell wall +relationship: part_of GO:0006952 ! defense response + +[Term] +id: GO:0052545 +name: callose localization +namespace: biological_process +def: "Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [GOC:mtg_pamgo_17jul06, PMID:18397379] +synonym: "callose localisation" EXACT [GOC:mah] +is_a: GO:0033037 ! polysaccharide localization + +[Term] +id: GO:0052546 +name: cell wall pectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall." [GOC:ai] +synonym: "cell wall pectin metabolism" EXACT [] +synonym: "cellulose and pectin-containing cell wall pectin metabolic process" EXACT [] +synonym: "pectin metabolism during cell wall biogenesis" EXACT [] +synonym: "plant-type cell wall pectin metabolic process" EXACT [] +is_a: GO:0045488 ! pectin metabolic process +relationship: part_of GO:0009664 ! plant-type cell wall organization + +[Term] +id: GO:0052547 +name: regulation of peptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:ai] +synonym: "peptidase regulator activity" RELATED [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0052548 +name: regulation of endopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:ai, GOC:hjd] +synonym: "protease regulator activity" NARROW [] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:0052553 +name: modulation by symbiont of host immune response +namespace: biological_process +alt_id: GO:0052552 +def: "Any process in which a symbiont modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "modulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052572 ! response to host immune response + +[Term] +id: GO:0052554 +name: obsolete modulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism modulates the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "modulation by organism of symbiont immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052557 +name: obsolete positive regulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates, maintains or increases the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "positive regulation by organism of symbiont immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052559 +name: induction by symbiont of host immune response +namespace: biological_process +alt_id: GO:0052555 +alt_id: GO:0052556 +alt_id: GO:0052558 +def: "Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "activation by symbiont of host immune response" EXACT [] +synonym: "induction by organism of immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "positive regulation by symbiont of host immune response" RELATED [] +synonym: "stimulation by symbiont of host immune response" RELATED [] +synonym: "up regulation by symbiont of host immune response" RELATED [] +synonym: "up-regulation by symbiont of host immune response" RELATED [] +synonym: "upregulation by symbiont of host immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052560 +name: obsolete induction by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism activates the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "induction by organism of symbiont immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052562 +name: suppression by symbiont of host immune response +namespace: biological_process +alt_id: GO:0052561 +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "down regulation by symbiont of host immune response" EXACT [] +synonym: "down-regulation by symbiont of host immune response" EXACT [] +synonym: "downregulation by symbiont of host immune response" EXACT [] +synonym: "inhibition by symbiont of host immune response" NARROW [] +synonym: "negative regulation by organism of immune response of other organism involved in symbiotic interaction" BROAD [] +synonym: "negative regulation by symbiont of host immune response" EXACT [] +is_a: GO:0052553 ! modulation by symbiont of host immune response + +[Term] +id: GO:0052563 +name: obsolete negative regulation by organism of symbiont immune response +namespace: biological_process +def: "OBSOLETE. Any process by which an organism stops, prevents, or reduces the frequency, rate or extent of the immune response of the symbiont organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "negative regulation by organism of symbiont immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052568 +name: obsolete response to symbiont phytoalexin production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phytoalexins produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "response to symbiont phytoalexin production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052569 +name: obsolete response to defense-related symbiont nitric oxide production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of nitric oxide produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "response to defense-related symbiont nitric oxide production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052570 +name: obsolete response to defense-related symbiont reactive oxygen species production +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species produced as part of the defense response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "response to defense-related symbiont reactive oxygen species production" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052571 +name: obsolete response to symbiont immune response +namespace: biological_process +def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo] +comment: This term was made obsolete because it does not represent a real biological process. +synonym: "response to symbiont immune response" EXACT [] +is_obsolete: true + +[Term] +id: GO:0052572 +name: response to host immune response +namespace: biological_process +alt_id: GO:0052564 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] +synonym: "response to immune response of other organism involved in symbiotic interaction" BROAD [] +is_a: GO:0052200 ! response to host defenses + +[Term] +id: GO:0052573 +name: UDP-D-galactose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "UDP-D-galactopyranose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-D-galactopyranose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-D-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "uridine diphosphate galactose metabolic process" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "uridine diphosphate galactose metabolism" EXACT [MetaCyc:UDP-GALACTOSE] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0052574 +name: UDP-galactose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of UDP-D-galactose, a substance composed of D-galactose in glycosidic linkage with guanosine diphosphate." [GOC:ai] +synonym: "UDP-D-galactopyranose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-D-galactopyranose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-D-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-D-galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "UDP-galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "uridine diphosphate galactose biosynthesis" EXACT [MetaCyc:UDP-GALACTOSE] +synonym: "uridine diphosphate galactose biosynthetic process" EXACT [MetaCyc:UDP-GALACTOSE] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0052573 ! UDP-D-galactose metabolic process + +[Term] +id: GO:0052575 +name: carbohydrate localization +namespace: biological_process +def: "Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:mah] +synonym: "carbohydrate localisation" EXACT [PMID:10758476] +is_a: GO:0033036 ! macromolecule localization + +[Term] +id: GO:0052576 +name: carbohydrate storage +namespace: biological_process +def: "The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [PMID:10758476] +is_a: GO:0052575 ! carbohydrate localization + +[Term] +id: GO:0052577 +name: germacrene-D synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate." [EC:4.2.3.22] +synonym: "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity" RELATED [EC:4.2.3.22] +xref: EC:4.2.3.22 +xref: KEGG_REACTION:R07648 +xref: MetaCyc:RXN-8562 +xref: RHEA:12016 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0052578 +name: alpha-farnesene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate." [MetaCyc:RXN-8574] +synonym: "(E,E)-alpha-farnesene synthase activity" EXACT [MetaCyc:RXN-8574] +xref: MetaCyc:RXN-8574 +xref: RHEA:27421 +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0052579 +name: (+)-pulegone reductase, (+)-isomenthone as substrate, activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5164] +synonym: "(+)-isomenthone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.81] +xref: EC:1.3.1.81 +xref: MetaCyc:RXN-5164 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052580 +name: (+)-pulegone reductase, (-)-menthone as substrate, activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+." [EC:1.3.1.81, MetaCyc:RXN-5163] +synonym: "(-)-menthone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.81] +xref: EC:1.3.1.81 +xref: MetaCyc:RXN-5164 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052581 +name: (-)-isopiperitenone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+)." [EC:1.3.1.82, RHEA:25649] +synonym: "(+)-cis-isopulegone:NADP+ oxidoreductase activity" RELATED [EC:1.3.1.82] +xref: EC:1.3.1.82 +xref: KEGG_REACTION:R06417 +xref: MetaCyc:RXN-5161 +xref: RHEA:25649 +is_a: GO:0035671 ! enone reductase activity + +[Term] +id: GO:0052582 +name: (+)-menthofuran synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+)." [EC:1.14.14.143, RHEA:25658] +synonym: "(+)-MFS activity" BROAD [EC:1.14.13.104] +synonym: "(+)-pulegone 9-hydroxylase activity" RELATED [EC:1.14.14.143] +synonym: "(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity" RELATED [EC:1.14.14.143] +synonym: "cytochrome P450 menthofuran synthase activity" RELATED [EC:1.14.14.143] +synonym: "menthofuran synthase activity" RELATED [EC:1.14.14.143] +xref: EC:1.14.14.143 +xref: KEGG_REACTION:R08923 +xref: MetaCyc:1.14.13.104-RXN +xref: RHEA:25658 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052583 +name: obsolete oxidoreductase activity, acting on halogen in donors +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] +comment: This term was obsoleted because EC obsoleted it, and there was no other evidence that this function exists. +xref: EC:1.22.-.- +is_obsolete: true + +[Term] +id: GO:0052584 +name: obsolete oxidoreductase activity, acting on halogen in donors, with NAD or NADP as acceptor +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction in which a halogen in the donor substance acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:mah] +comment: This term was obsoleted because EC obsoleted it, and there was no other evidence that this function exists. +xref: EC:1.22.1.- +is_obsolete: true + +[Term] +id: GO:0052585 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:ai] +xref: EC:1.4.5.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0052586 +name: oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound." [GOC:jl] +xref: EC:1.7.5.- +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0052587 +name: diacetyl reductase ((R)-acetoin forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.303, RHEA:22900] +synonym: "(R)-acetoin dehydrogenase activity" RELATED [EC:1.1.1.303] +xref: EC:1.1.1.303 +xref: KEGG_REACTION:R02855 +xref: MetaCyc:RXN-11036 +xref: RHEA:22900 +is_a: GO:0019152 ! acetoin dehydrogenase activity + +[Term] +id: GO:0052588 +name: diacetyl reductase ((S)-acetoin forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH." [EC:1.1.1.304, RHEA:27286] +synonym: "(S)-acetoin dehydrogenase activity" RELATED [EC:1.1.1.304] +xref: EC:1.1.1.304 +xref: KEGG_REACTION:R09078 +xref: MetaCyc:RXN-11032 +xref: RHEA:27286 +is_a: GO:0019152 ! acetoin dehydrogenase activity + +[Term] +id: GO:0052589 +name: malate dehydrogenase (menaquinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol." [MetaCyc:RXNI-3] +synonym: "(S)-malate:(menaquinone) oxidoreductase activity" RELATED [EC:1.1.5.4] +synonym: "(S)-malate:menaquinone oxidoreductase activity" RELATED [EC:1.1.5.4] +xref: EC:1.1.5.4 +xref: MetaCyc:RXNI-3 +is_a: GO:0016615 ! malate dehydrogenase activity +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0052590 +name: sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol." [MetaCyc:RXN0-5258] +comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. +xref: EC:1.1.5.3 +xref: MetaCyc:RXN0-5258 +is_a: GO:0004368 ! glycerol-3-phosphate dehydrogenase (quinone) activity + +[Term] +id: GO:0052591 +name: sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." [MetaCyc:GLYC3PDEHYDROG-RXN] +comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. +xref: EC:1.1.5.3 +xref: MetaCyc:GLYC3PDEHYDROG-RXN +xref: RHEA:28751 +is_a: GO:0052590 ! sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity + +[Term] +id: GO:0052592 +name: oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] +synonym: "oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor" EXACT [] +xref: EC:1.17.7.- +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0052593 +name: tryptamine:oxygen oxidoreductase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+." [MetaCyc:RXN-1401] +xref: EC:1.4.3.21 +xref: KEGG_REACTION:R02173 +xref: MetaCyc:RXN-1401 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052594 +name: aminoacetone:oxygen oxidoreductase(deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." [MetaCyc:AMACETOXID-RXN] +xref: EC:1.4.3.21 +xref: KEGG_REACTION:R02529 +xref: MetaCyc:AMACETOXID-RXN +xref: RHEA:28186 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052595 +name: aliphatic-amine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEOXID-RXN] +synonym: "aliphatic-amine:oxygen oxidoreductase(deaminating) activity" EXACT [] +xref: EC:1.4.3.21 +xref: MetaCyc:AMINEOXID-RXN +xref: RHEA:16153 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052596 +name: phenethylamine:oxygen oxidoreductase (deaminating) activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:AMINEPHEN-RXN] +xref: EC:1.4.3.21 +xref: KEGG_REACTION:R02613 +xref: MetaCyc:AMINEPHEN-RXN +xref: RHEA:25265 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052597 +name: diamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide." [MetaCyc:RXN-9599] +synonym: "diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] +xref: EC:1.4.3.22 +xref: MetaCyc:RXN-9599 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052598 +name: histamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-9600] +synonym: "1H-Imidazole-4-ethanamine oxidase activity" EXACT [KEGG_REACTION:R02150] +synonym: "1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity" EXACT [KEGG_REACTION:R02150] +synonym: "histamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] +xref: EC:1.4.3.22 +xref: KEGG_REACTION:R02150 +xref: MetaCyc:RXN-9600 +xref: Reactome:R-HSA-5696131 "AOC1 deaminates Hist" +xref: RHEA:25625 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052599 +name: methylputrescine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-8244] +synonym: "N-methylputrescine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] +xref: EC:1.4.3.22 +xref: KEGG_REACTION:R05334 +xref: MetaCyc:RXN-8244 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052600 +name: propane-1,3-diamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+." [MetaCyc:RXN-6381] +synonym: "1,3-diaminopropane oxidase activity" EXACT [KEGG:C00986] +synonym: "propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.22] +synonym: "trimethylenediamine oxidase activity" EXACT [CHEBI:15725] +xref: EC:1.4.3.22 +xref: KEGG_REACTION:R03139 +xref: MetaCyc:RXN-6381 +xref: RHEA:30895 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0052601 +name: (S)-limonene 1,2-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide." [MetaCyc:RXN-9409, PMID:8820855] +synonym: "(-)-limonene 1,2-monooxygenase activity" RELATED [EC:1.14.13.107] +synonym: "(-)-limonene,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.107] +synonym: "(S)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] +xref: EC:1.14.13.107 +xref: KEGG_REACTION:R09385 "(S)-limonene,NADH:oxygen oxidoreductase" +xref: KEGG_REACTION:R09389 "(S)-limonene,NADPH:oxygen oxidoreductase" +xref: MetaCyc:RXN-9409 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0052602 +name: 4-chloronitrobenzene nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O." [MetaCyc:RXN-8833] +xref: MetaCyc:RXN-8833 +xref: UM-BBD_enzymeID:e0245 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0052603 +name: 1-chloro-4-nitrosobenzene nitroreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O." [MetaCyc:RXN-8834] +xref: MetaCyc:RXN-8834 +xref: UM-BBD_enzymeID:e0245 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0052604 +name: delta-tocopherol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol." [MetaCyc:RXN-2561, PMID:12213958] +xref: KEGG_REACTION:R07503 +xref: MetaCyc:RXN-2561 +xref: RHEA:37987 +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0052605 +name: gamma-tocopherol cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol." [MetaCyc:RXN-2543, PMID:12213958] +xref: KEGG_REACTION:R07502 +xref: MetaCyc:RXN-2543 +xref: RHEA:37983 +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0052606 +name: chlorophyllide a oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O." [EC:1.13.12.14, MetaCyc:RXN-7676] +synonym: "CAO activity" BROAD [EC:1.13.12.14] +synonym: "chlorophyll a oxygenase activity" EXACT [] +synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" RELATED [EC:1.13.12.14] +synonym: "chlorophyllide-a oxygenase activity" RELATED [EC:1.13.12.14] +xref: KEGG_REACTION:R08203 +xref: MetaCyc:RXN-7676 +xref: RHEA:22676 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity + +[Term] +id: GO:0052607 +name: 7-hydroxy-chlorophyllide a oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O." [EC:1.13.12.14, MetaCyc:RXN-7677] +synonym: "7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity" RELATED [EC:1.13.12.14] +synonym: "7-hydroxychlorophyllide-a oxygenase activity" RELATED [EC:1.13.12.14] +synonym: "CAO activity" BROAD [EC:1.13.12.14] +synonym: "chlorophyll b synthetase activity" EXACT [] +synonym: "chlorophyll-b synthase activity" RELATED [EC:1.13.12.14] +xref: KEGG_REACTION:R08204 +xref: MetaCyc:RXN-7677 +xref: RHEA:22136 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) +relationship: part_of GO:0010277 ! chlorophyllide a oxygenase [overall] activity + +[Term] +id: GO:0052608 +name: echinenone 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8214] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8214 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052609 +name: 4-ketotorulene 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8218] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8218 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052610 +name: beta-cryptoxanthin hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O." [RHEA:30327] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8026 +xref: RHEA:30327 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052611 +name: beta-carotene 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O." [RHEA:30323] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8025 +xref: RHEA:30323 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052612 +name: adonirubin 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8187] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8187 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052613 +name: canthaxanthin 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O." [MetaCyc:RXN-8186] +synonym: "beta-carotene hydroxylase activity" BROAD [] +synonym: "beta-ring carotenoid 3-hydroxylase activity" BROAD [MetaCyc:MONOMER-12386] +synonym: "carotene beta-ring hydroxylase activity" BROAD [] +xref: MetaCyc:RXN-8186 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052614 +name: uracil oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate." [MetaCyc:RXN0-6444, PMID:20369853, PMID:20400551] +synonym: "pyrimidine oxygenase activity" BROAD [MetaCyc:RXN0-6444] +xref: MetaCyc:RXN0-6444 +xref: RHEA:31587 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0052615 +name: ent-kaurene oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol." [MetaCyc:1.14.13.78-RXN] +xref: EC:1.14.14.86 +xref: MetaCyc:1.14.13.78-RXN +xref: RHEA:32323 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052616 +name: ent-kaur-16-en-19-ol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al." [MetaCyc:RXN-5242] +xref: EC:1.14.14.86 +xref: MetaCyc:RXN-5242 +xref: RHEA:21304 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052617 +name: ent-kaur-16-en-19-al oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate." [MetaCyc:RXN-7580] +xref: EC:1.14.14.86 +xref: MetaCyc:RXN-7580 +xref: RHEA:10928 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052618 +name: coenzyme F420-0:L-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate." [MetaCyc:RXN-8080] +xref: EC:6.3.2.31 +xref: MetaCyc:RXN-8080 +xref: RHEA:30555 +is_a: GO:0043773 ! coenzyme F420-0 gamma-glutamyl ligase activity + +[Term] +id: GO:0052619 +name: coenzyme F420-1:gamma-L-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate." [MetaCyc:RXN-8081] +xref: EC:6.3.2.34 +xref: MetaCyc:RXN-8081 +xref: RHEA:30523 +is_a: GO:0043773 ! coenzyme F420-0 gamma-glutamyl ligase activity + +[Term] +id: GO:0052620 +name: thymine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2." [RHEA:13469] +xref: EC:1.17.99.4 +xref: MetaCyc:RXN-8646 +xref: RHEA:13469 +is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups + +[Term] +id: GO:0052621 +name: diguanylate cyclase activity +namespace: molecular_function +alt_id: GO:0043789 +def: "Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+)." [EC:2.7.7.65, RHEA:24898] +synonym: "GTP:GTP guanylyltransferase activity" BROAD [EC:2.7.7.65] +xref: EC:2.7.7.65 +xref: KEGG_REACTION:R08057 +xref: MetaCyc:RXN0-5359 +xref: RHEA:24898 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0052622 +name: ATP dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate." [EC:2.5.1.27, MetaCyc:RXN-4303] +synonym: "2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity" EXACT [] +synonym: "2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R08052] +synonym: "ATP isopentenyltransferase activity" EXACT [] +synonym: "dimethylallyl-diphosphate:ATP dimethylallyltransferase activity" RELATED [EC:2.5.1.27] +xref: EC:2.5.1.- +xref: KEGG_REACTION:R08052 +xref: MetaCyc:RXN-4303 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0052623 +name: ADP dimethylallyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate." [EC:2.5.1.27, MetaCyc:RXN-4305] +synonym: "2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity" EXACT [] +synonym: "2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity" EXACT [KEGG_REACTION:R08051] +synonym: "ADP isopentenyltransferase activity" EXACT [] +synonym: "dimethylallyl-diphosphate:ADP dimethylallyltransferase activity" RELATED [EC:2.5.1.27] +xref: EC:2.5.1.- +xref: KEGG_REACTION:R08051 +xref: MetaCyc:RXN-4305 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0052624 +name: 2-phytyl-1,4-naphthoquinone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+." [MetaCyc:RXN-6723, MetaCyc:RXN-7569, PMID:14617060] +synonym: "demethylphylloquinone methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity" EXACT [] +synonym: "SA methyltransferase activity" BROAD [] +synonym: "salicylate methyltransferase activity" BROAD [] +synonym: "salicylic acid methyltransferase activity" BROAD [] +xref: KEGG_REACTION:R06859 +xref: MetaCyc:RXN-6723 +xref: MetaCyc:RXN-7569 +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0052625 +name: 4-aminobenzoate amino acid synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] +synonym: "4-aminobenzoyl amino acid synthetase activity" EXACT [] +synonym: "p-aminobenzoate amino acid synthetase activity" EXACT [] +synonym: "p-aminobenzoyl amino acid synthetase activity" EXACT [] +synonym: "pABA amino acid synthetase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0052626 +name: benzoate amino acid synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10886, PMID:19189963] +synonym: "benzoyl amino acid synthetase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0052627 +name: vanillate amino acid synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10885, PMID:19189963] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0052628 +name: 4-hydroxybenzoate amino acid synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate." [MetaCyc:RXN-10884, PMID:19189963] +synonym: "4-hydroxybenzoyl amino acid synthetase activity" EXACT [] +synonym: "4HBA amino acid synthetase activity" EXACT [] +synonym: "p-hydroxybenzoate amino acid synthetase activity" EXACT [] +synonym: "p-hydroxybenzoyl amino acid synthetase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0052629 +name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+." [PMID:19901554, RHEA:39019] +xref: EC:3.1.3.95 +xref: MetaCyc:RXN-10958 +xref: Reactome:R-HSA-1676065 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane" +xref: Reactome:R-HSA-1676105 "PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane" +xref: Reactome:R-HSA-1676203 "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane" +xref: Reactome:R-HSA-6809320 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane" +xref: Reactome:R-HSA-6809778 "PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1" +xref: Reactome:R-HSA-6809944 "PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane" +xref: RHEA:39019 +is_a: GO:0106018 ! phosphatidylinositol-3,5-bisphosphate phosphatase activity + +[Term] +id: GO:0052630 +name: UDP-N-acetylgalactosamine diphosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine." [EC:2.7.7.83, RHEA:34363] +synonym: "N-acetylgalactosamine 1-phosphate uridylyltransferase" EXACT [] +synonym: "N-acetylgalactosamine-1-phosphate uridyltransferase activity" EXACT [] +synonym: "UDP-acetylgalactosamine pyrophosphorylase activity" EXACT [] +synonym: "UDP-GalNAc pyrophosphorylase activity" EXACT [] +synonym: "UDP-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] +synonym: "uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity" EXACT [] +synonym: "uridine diphosphoacetylgalactosamine phosphorylase activity" EXACT [] +synonym: "uridine diphosphoacetylgalactosamine pyrophosphorylase activity" EXACT [] +synonym: "UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [] +synonym: "UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity" EXACT [] +xref: EC:2.7.7.83 +xref: RHEA:34363 +is_a: GO:0070569 ! uridylyltransferase activity + +[Term] +id: GO:0052631 +name: sphingolipid delta-8 desaturase activity +namespace: molecular_function +def: "Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8)." [PMID:17600137, PMID:9786850] +xref: MetaCyc:RXN-7798 +xref: RHEA:46268 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0052633 +name: isocitrate hydro-lyase (cis-aconitate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: cis-aconitate + H2O = isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw, MetaCyc:ACONITATEHYDR-RXN] +synonym: "aconitate hydratase activity" BROAD [EC:4.2.1.3] +synonym: "cis-aconitase activity" BROAD [EC:4.2.1.3] +synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" BROAD [EC:4.2.1.3] +synonym: "citrate(isocitrate) hydro-lyase activity" BROAD [EC:4.2.1.3] +xref: KEGG_REACTION:R01900 +xref: MetaCyc:ACONITATEHYDR-RXN +xref: RHEA:22144 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0052634 +name: C-19 gibberellin 2-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons." [EC:1.14.11.13, GOC:kad] +synonym: "(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] +synonym: "C(19) gibberellin 2-oxidase activity" EXACT [] +synonym: "C-19 GA 2-oxidase activity" EXACT [] +synonym: "C-19 gibberellin 2-beta-hydroxylase activity" EXACT [] +synonym: "C-19 gibberellin 2-oxidase activity" EXACT [] +synonym: "C-19 gibberellin 2beta-dioxygenase activity" EXACT [] +synonym: "C-19 gibberellin 2beta-hydroxylase activity" EXACT [] +xref: EC:1.14.11.13 +is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity + +[Term] +id: GO:0052635 +name: C-20 gibberellin 2-beta-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons." [EC:1.14.11.13, GOC:kad] +synonym: "(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)" EXACT [] +synonym: "C(20) gibberellin 2-oxidase activity" EXACT [] +synonym: "C-20 GA 2-oxidase activity" EXACT [] +synonym: "C-20 gibberellin 2-beta-hydroxylase activity" EXACT [] +synonym: "C-20 gibberellin 2-oxidase activity" EXACT [] +synonym: "C-20 gibberellin 2beta-dioxygenase activity" EXACT [] +synonym: "C-20 gibberellin 2beta-hydroxylase activity" EXACT [] +is_a: GO:0045543 ! gibberellin 2-beta-dioxygenase activity + +[Term] +id: GO:0052636 +name: arabinosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor)." [GOC:ai] +synonym: "arabinosyl transferase activity" EXACT [] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0052637 +name: delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol." [GOC:ai, MetaCyc:RXN-8319, PMID:19682287] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0052638 +name: indole-3-butyrate beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP." [MetaCyc:RXN-11655, RHEA:62708] +synonym: "IBA-Glc synthetase activity" EXACT [] +synonym: "IBA-glucose synthase activity" EXACT [] +synonym: "IBAGlu synthase activity" EXACT [] +synonym: "indol-3-ylbutyrylglucose synthase activity" EXACT [] +synonym: "indole-3-butyric acid glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity" EXACT [] +synonym: "UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity" EXACT [] +synonym: "UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity" EXACT [] +synonym: "UDPG-indol-3-ylbutyryl glucosyl transferase activity" EXACT [] +synonym: "UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity" EXACT [] +synonym: "uridine diphosphoglucose-indolebutyrate glucosyltransferase activity" EXACT [] +xref: MetaCyc:RXN-11655 +xref: RHEA:62708 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0052639 +name: salicylic acid glucosyltransferase (ester-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP." [MetaCyc:RXN-11659, RHEA:62316] +synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11659] +synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] +synonym: "UDP:glucose:SA glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] +synonym: "UDP:glucose:salicylate glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] +synonym: "UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity" EXACT [MetaCyc:RXN-11659] +xref: MetaCyc:RXN-11659 +xref: RHEA:62316 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0052640 +name: salicylic acid glucosyltransferase (glucoside-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP." [MetaCyc:RXN-11658, RHEA:62312] +synonym: "salicylic acid glucosyltransferase activity" BROAD [MetaCyc:RXN-11658] +synonym: "UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] +synonym: "UDP:glucose:SA glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] +synonym: "UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] +synonym: "UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity" EXACT [MetaCyc:RXN-11658] +xref: MetaCyc:RXN-11658 +xref: RHEA:62312 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0052641 +name: benzoic acid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP." [MetaCyc:RXN-11660] +synonym: "benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] +synonym: "UDP:glucose:BA glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] +synonym: "UDP:glucose:benzoate glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] +synonym: "UDP:glucose:benzoic acid glucosyltransferase activity" EXACT [MetaCyc:RXN-11660] +xref: MetaCyc:RXN-11660 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0052642 +name: lysophosphatidic acid phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol." [PMID:20045079, PMID:7966317] +synonym: "LPA phosphatase activity" EXACT [] +synonym: "lysophosphatidate phosphatase activity" EXACT [] +xref: Reactome:R-HSA-8878654 "ACP6 hydrolyses MYS-LPA" +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0052643 +name: chlorophyllide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyllides, any chlorophyll lacking the terpenoid side chain such as phytyl or farnesyl." [PMID:7724548] +synonym: "chlorophyllide metabolism" EXACT [] +is_a: GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0052644 +name: chlorophyllide a metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chlorophyllide a, a chlorophyll lacking the terpenoid side chain, which is the functional parent of chlorophyll a." [PMID:7724548] +synonym: "chlorophyllide a metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0052643 ! chlorophyllide metabolic process + +[Term] +id: GO:0052645 +name: F420-0 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving F420-0 (5-O-{[(1S)-1-carboxyethoxy](hydroxy)phosphoryl}-1-deoxy-1-(8-hydroxy-2,4-dioxo-2H-pyrimido[4,5-b]quinolin-10(4H)-yl)-D-ribitol), the fragment of coenzyme F420 remaining after formal hydrolytic removal of all of the glutamate residues." [GOC:curators] +synonym: "coenzyme F420-0 metabolic process" EXACT [CHEBI:59532] +synonym: "coenzyme F420-0 metabolism" EXACT [CHEBI:59532] +synonym: "F(420)-0 metabolic process" EXACT [CHEBI:59532] +synonym: "F420-0 metabolism" EXACT [] +is_a: GO:0019520 ! aldonic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0052648 ! ribitol phosphate metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0052646 +name: alditol phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alditol phosphates, any phosphorylated polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [PMID:30240188] +synonym: "alditol phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0052647 +name: pentitol phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentitol phosphates, any phosphorylated alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] +synonym: "pentitol phosphate metabolism" EXACT [] +is_a: GO:0052646 ! alditol phosphate metabolic process + +[Term] +id: GO:0052648 +name: ribitol phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ribitol phosphates, any phosphorylated form of ribitol, the pentitol derived formally by reduction of the -CHO group of either D- or L-ribose." [ISBN:0198506732] +synonym: "ribitol phosphate metabolism" EXACT [] +is_a: GO:0052647 ! pentitol phosphate metabolic process + +[Term] +id: GO:0052649 +name: coenzyme gamma-F420-2 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving coenzyme gamma-F420-2 (F420-2; coenzyme F420; N-{N-[O-(7,8-didemethyl-8-hydroxy-5-deazariboflavin phospho)-(S)-lactyl]-gamma-L-glutamyl}-L-glutamate), the amide obtained by formal condensation of the carboxylic acid group of F420-0 with the amino group of L-gamma-glutamyl-L-glutamic acid." [GOC:curators] +synonym: "coenzyme F420 metabolic process" EXACT [CHEBI:16848] +synonym: "coenzyme F420 metabolism" EXACT [CHEBI:16848] +synonym: "coenzyme gamma-F420-2 metabolism" EXACT [] +synonym: "F420-2 metabolic process" EXACT [CHEBI:16848] +synonym: "F420-2 metabolism" EXACT [CHEBI:16848] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0052648 ! ribitol phosphate metabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0052650 +name: NADP-retinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+." [RHEA:25033] +synonym: "all-trans retinal reductase activity" BROAD [EC:1.1.1.300] +synonym: "all-trans-retinol dehydrogenase activity" BROAD [EC:1.1.1.300] +synonym: "NADP(H)-dependent retinol dehydrogenase/reductase activity" RELATED [EC:1.1.1.300] +synonym: "retinol dehydrogenase [NADP+] activity" RELATED [EC:1.1.1.300] +synonym: "retinol dehydrogenase activity" BROAD [] +synonym: "retinol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.300] +xref: EC:1.1.1.300 +xref: KEGG_REACTION:R08379 +xref: MetaCyc:RXN-10841 +xref: Reactome:R-HSA-2464803 "RDH8 reduces atRAL to atROL" +xref: Reactome:R-HSA-2464822 "RDH12 reduces atRAL to atROL" +xref: Reactome:R-HSA-2465921 "11cRDH oxidises 11cROL to 11cRAL" +xref: Reactome:R-HSA-2465940 "atRAL is reduced to atROL" +xref: Reactome:R-HSA-2466861 "Defective RDH12 does not reduce atRAL to atROL and causes LCA13" +xref: Reactome:R-HSA-2471670 "Defective RDH12 does not reduce atRAL to atROL" +xref: Reactome:R-HSA-5419165 "RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL" +xref: Reactome:R-HSA-5615668 "AKR1C3 reduces atRAL to atROL" +xref: Reactome:R-HSA-5623643 "RDH13 reduces atRAL to atROL" +xref: Reactome:R-HSA-74872 "RDH10,11 oxidise 11cROL to 11cRAL" +xref: RHEA:25033 +is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity + +[Term] +id: GO:0052651 +name: monoacylglycerol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [PMID:25290914] +synonym: "monoacylglycerol breakdown" EXACT [] +synonym: "monoacylglycerol catabolism" EXACT [] +synonym: "monoacylglycerol degradation" EXACT [] +is_a: GO:0046462 ! monoacylglycerol metabolic process +is_a: GO:0046464 ! acylglycerol catabolic process + +[Term] +id: GO:0052652 +name: cyclic purine nucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [PMID:23911318] +synonym: "cyclic purine nucleotide metabolism" EXACT [] +is_a: GO:0006164 ! purine nucleotide biosynthetic process +is_a: GO:0009190 ! cyclic nucleotide biosynthetic process + +[Term] +id: GO:0052653 +name: 3',5'-cyclic diguanylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3',5'-cyclic diguanylic acid, a cyclic purine dinucleotide in which the base groups are guanine." [GOC:curators] +synonym: "3',5'-cyclic diguanylic acid metabolism" EXACT [] +synonym: "cdiGMP metabolic process" EXACT [] +synonym: "cdiGMP metabolism" EXACT [] +synonym: "cyclic diguanylate metabolic process" EXACT [] +synonym: "cyclic diguanylate metabolism" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0052652 ! cyclic purine nucleotide metabolic process + +[Term] +id: GO:0052654 +name: L-leucine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN] +subset: goslim_chembl +synonym: "L-leucine aminotransferase activity" EXACT [] +xref: EC:2.6.1.42 +xref: KEGG_REACTION:R01090 +xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN +is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity + +[Term] +id: GO:0052655 +name: L-valine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN] +subset: goslim_chembl +synonym: "L-valine aminotransferase activity" EXACT [] +xref: EC:2.6.1.42 +xref: KEGG_REACTION:R01214 +xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN +xref: RHEA:24813 +is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity + +[Term] +id: GO:0052656 +name: L-isoleucine transaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN] +subset: goslim_chembl +synonym: "L-isoleucine aminotransferase activity" EXACT [] +xref: EC:2.6.1.42 +xref: KEGG_REACTION:R02199 +xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN +xref: RHEA:24801 +is_a: GO:0004084 ! branched-chain-amino-acid transaminase activity + +[Term] +id: GO:0052657 +name: guanine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] +synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "GMP pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "GPRT" RELATED [EC:2.4.2.8] +synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] +synonym: "guanosine 5'-phosphate pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "guanosine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "guanylate pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "guanylic pyrophosphorylase activity" RELATED [EC:2.4.2.8] +synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] +synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] +synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] +xref: EC:2.4.2.8 +xref: KEGG_REACTION:R01229 +xref: MetaCyc:GUANPRIBOSYLTRAN-RXN +xref: RHEA:25424 +is_a: GO:0106130 ! purine phosphoribosyltransferase activity + +[Term] +id: GO:0052658 +name: inositol-1,4,5-trisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate." [EC:3.1.3.56, RHEA:19797] +synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" RELATED [EC:3.1.3.56] +synonym: "5PTase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] +synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "inositol triphosphate 5-phosphomonoesterase activity" BROAD [] +synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] +synonym: "Ins(1,4,5)P3 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "InsP(3) 5-phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "InsP3 5-phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] +synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] +xref: EC:3.1.3.56 +xref: KEGG_REACTION:R03394 +xref: MetaCyc:3.1.3.56-RXN +xref: Reactome:R-HSA-1855174 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol" +xref: Reactome:R-HSA-1855222 "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane" +xref: RHEA:19797 +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0052659 +name: inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56, RHEA:11392] +synonym: "5PTase activity" RELATED [EC:3.1.3.56] +synonym: "D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "inositol polyphosphate-5-phosphatase activity" BROAD [EC:3.1.3.56] +synonym: "Ins(1,3,4,5)P(4) 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "Ins(1,3,4,5)P4 5-phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] +synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] +xref: EC:3.1.3.56 +xref: KEGG_REACTION:R03430 +xref: MetaCyc:RXN-8730 +xref: Reactome:R-HSA-1855213 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane" +xref: Reactome:R-HSA-1855218 "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol" +xref: RHEA:11392 +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:0052660 +name: R-lactaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+." [RHEA:23872] +synonym: "(R)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77] +synonym: "D-lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77] +xref: KEGG_REACTION:R03080 +xref: MetaCyc:RXN-8641 +xref: RHEA:23872 +is_a: GO:0008912 ! lactaldehyde reductase activity + +[Term] +id: GO:0052661 +name: S-lactaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+." [RHEA:15933] +synonym: "(S)-propane-1,2-diol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.77] +synonym: "L-lactaldehyde:propanediol oxidoreductase activity" RELATED [EC:1.1.1.77] +xref: KEGG_REACTION:R02258 +xref: MetaCyc:LACTALDREDUCT-RXN +xref: RHEA:15933 +is_a: GO:0008912 ! lactaldehyde reductase activity + +[Term] +id: GO:0052662 +name: zeaxanthin epoxidase activity +namespace: molecular_function +alt_id: GO:0009540 +alt_id: GO:0052663 +def: "Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]." [RHEA:32443] +comment: Multi-step reaction: RHEA:14937 and RHEA:24084. Formerly EC:1.14.13.90. +synonym: "antheraxanthin epoxidase activity" NARROW [] +synonym: "zea-epoxidase activity" RELATED [EC:1.14.15.21] +synonym: "zeaxanthin epoxidase [overall] activity" RELATED [] +xref: EC:1.14.15.21 +xref: KEGG_REACTION:R06946 "zeaxanthin,NADH:oxygen oxidoreductase activity" +xref: KEGG_REACTION:R06947 "antheraxanthin,NADH:oxygen oxidoreductase activity" +xref: KEGG_REACTION:R07199 "zeaxanthin,NADPH:oxygen oxidoreductase activity" +xref: KEGG_REACTION:R07200 "antheraxanthin,NADPH:oxygen oxidoreductase activity" +xref: MetaCyc:RXN-7978 +xref: MetaCyc:RXN-7979 +xref: RHEA:24084 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052664 +name: nitroalkane oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2." [EC:1.7.3.1] +synonym: "NAO activity" RELATED [EC:1.7.3.1] +synonym: "nitroalkane reductase activity" RELATED [EC:1.7.3.1] +synonym: "nitroalkane:oxygen oxidoreductase activity" RELATED [EC:1.7.3.1] +xref: EC:1.7.3.1 +xref: KEGG_REACTION:R00799 +xref: MetaCyc:RXN-11045 +is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor + +[Term] +id: GO:0052665 +name: tRNA (uracil-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil." [PMID:25626150, RHEA:43100] +synonym: "S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity" RELATED [EC:2.1.1.211] +synonym: "transfer ribonucleate uracil 2'-methyltransferase activity" RELATED [EC:2.1.1.34] +synonym: "tRNA (uracil 2')-methyltransferase activity" RELATED [EC:2.1.1.211] +synonym: "tRNA uracil 2'-methyltransferase activity" RELATED [EC:2.1.1.211] +synonym: "tRNA uracil-2'-O-methyltransferase activity" RELATED [EC:2.1.1.211] +xref: EC:2.1.1.34 +xref: MetaCyc:RXN0-5143 +xref: Reactome:R-HSA-6788707 "TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)" +xref: RHEA:43100 +is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity +is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity + +[Term] +id: GO:0052666 +name: tRNA (cytosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine." [GOC:hjd] +synonym: "S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity" EXACT [] +synonym: "transfer ribonucleate cytosine 2'-methyltransferase activity" EXACT [] +synonym: "tRNA (cytosine 2')-methyltransferase activity" EXACT [] +synonym: "tRNA cytosine 2'-methyltransferase activity" EXACT [] +synonym: "tRNA cytosine-2'-O-methyltransferase activity" EXACT [] +xref: MetaCyc:RXN0-5143 +xref: Reactome:R-HSA-6788668 "TRMT13 2'-O-methylates adenosine-4 in tRNA" +xref: Reactome:R-HSA-6788684 "TRMT13 2'-O-methylates cytidine-4 in tRNA" +xref: Reactome:R-HSA-9024159 "FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)" +is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0052667 +name: phosphomethylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)." [RHEA:25321] +synonym: "N-methylethanolamine phosphate N-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity" EXACT systematic_synonym [KEGG_REACTION:R06868] +xref: EC:2.1.1.103 +xref: KEGG_REACTION:R06868 +xref: MetaCyc:RXN-5642 +xref: RHEA:25321 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0052668 +name: CTP:farnesol kinase activity +namespace: molecular_function +alt_id: GO:0052669 +def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+." [PMID:21395888, RHEA:51680] +synonym: "CTP:2-trans,-6-trans-farnesol kinase activity" EXACT [] +synonym: "CTP:2-trans,-6-trans-farnesol phosphotransferase activity" EXACT [] +synonym: "farnesol kinase activity" RELATED [] +synonym: "farnesol phosphotransferase activity" EXACT [] +synonym: "trans,trans-farnesol kinase activity" NARROW [] +xref: EC:2.7.1.216 +xref: MetaCyc:RXN-11625 +xref: RHEA:51680 +is_a: GO:0052673 ! prenol kinase activity + +[Term] +id: GO:0052670 +name: geraniol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate." [GOC:kd] +synonym: "geraniol phosphotransferase activity" EXACT [] +is_a: GO:0052673 ! prenol kinase activity + +[Term] +id: GO:0052671 +name: geranylgeraniol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate." [GOC:kd, MetaCyc:RXN-11629] +synonym: "geranylgeraniol phosphotransferase activity" EXACT [] +is_a: GO:0052673 ! prenol kinase activity + +[Term] +id: GO:0052672 +name: CTP:geranylgeraniol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP." [MetaCyc:RXN-11629] +synonym: "CTP:geranylgeraniol phosphotransferase activity" EXACT [] +xref: EC:2.7.1.216 +xref: MetaCyc:RXN-11629 +is_a: GO:0052671 ! geranylgeraniol kinase activity + +[Term] +id: GO:0052673 +name: prenol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity." [GOC:ai, GOC:kd] +synonym: "prenol phosphotransferase activity" EXACT [] +synonym: "prenyl alcohol kinase activity" EXACT [] +synonym: "prenyl alcohol phosphotransferase activity" EXACT [] +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0052674 +name: ent-pimara-9(11),15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate." [RHEA:25544] +synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.31] +synonym: "PMD synthase activity" BROAD [EC:4.2.3.31] +xref: EC:4.2.3.31 +xref: MetaCyc:RXN-9299 +xref: RHEA:25544 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052675 +name: 3-methylbutanol:NADP oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG_REACTION:R05686] +synonym: "3-methylbutanal reductase (NADP) activity" EXACT [] +synonym: "3-methylbutanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.265] +synonym: "3-methylbutyraldehyde reductase (NADP) activity" EXACT [] +synonym: "isoamyl alcohol oxidase (NADP) activity" EXACT [] +xref: KEGG_REACTION:R05686 +xref: RHEA:18525 +is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity + +[Term] +id: GO:0052676 +name: 3-methylbutanol:NAD oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde." [EC:1.1.1.265, KEGG_REACTION:R05685] +synonym: "3-methylbutanal reductase (NAD) activity" EXACT [] +synonym: "3-methylbutanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.265] +synonym: "3-methylbutyraldehyde reductase (NAD) activity" EXACT [] +synonym: "isoamyl alcohol oxidase (NAD) activity" EXACT [] +xref: KEGG_REACTION:R05685 +xref: RHEA:18529 +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:0052677 +name: D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+." [EC:1.1.1.287] +synonym: "ARD1p" RELATED [EC:1.1.1.287] +synonym: "D-arabinitol dehydrogenase 1 activity" BROAD [EC:1.1.1.287] +synonym: "D-arabinitol:NADP+ dehydrogenase activity" BROAD [EC:1.1.1.287] +synonym: "NADP+-dependent D-arabinitol dehydrogenase activity" BROAD [EC:1.1.1.287] +xref: KEGG_REACTION:R07143 +xref: MetaCyc:RXN-7971 +xref: RHEA:21276 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052678 +name: levopimaradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate." [RHEA:25548] +synonym: "ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity" EXACT systematic_synonym [EC:4.2.3.32] +xref: EC:4.2.3.32 +xref: KEGG_REACTION:R06302 +xref: MetaCyc:4.2.3.32-RXN +xref: RHEA:25548 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052679 +name: terpentetriene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene." [RHEA:25617] +synonym: "terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity" EXACT systematic_synonym [EC:4.2.3.36] +xref: EC:4.2.3.36 +xref: MetaCyc:RXN-9455 +xref: RHEA:25617 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052680 +name: epi-isozizaene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate." [RHEA:25992] +synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity" EXACT systematic_synonym [EC:4.2.3.37, KEGG_REACTION:R07830] +xref: EC:4.2.3.37 +xref: KEGG_REACTION:R07830 +xref: MetaCyc:RXN-9349 +xref: RHEA:25992 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052681 +name: alpha-bisabolene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate." [RHEA:25436] +synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.38] +synonym: "bisabolene synthase activity" BROAD [KEGG_REACTION:R08370] +xref: EC:4.2.3.38 +xref: KEGG_REACTION:R08370 +xref: MetaCyc:RXN-8550 +xref: RHEA:25436 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052682 +name: epi-cedrol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate." [RHEA:26115] +synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity" EXACT systematic_synonym [EC:4.2.3.39] +synonym: "8-epicedrol synthase activity" EXACT [] +synonym: "epicedrol synthase activity" EXACT [] +xref: EC:4.2.3.39 +xref: KEGG_REACTION:R09140 +xref: MetaCyc:RXN-10004 +xref: RHEA:26115 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052683 +name: (Z)-gamma-bisabolene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate." [RHEA:26081] +synonym: "(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity" EXACT systematic_synonym [EC:4.2.3.40] +xref: EC:4.2.3.40 +xref: MetaCyc:RXN-10005 +xref: RHEA:26081 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0052684 +name: L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O." [MetaCyc:RXN0-2382] +synonym: "L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity" EXACT [GOC:bf] +synonym: "tryptophan synthase beta subunit activity" NARROW [] +xref: EC:4.2.1.122 +xref: KEGG_REACTION:R00674 +xref: MetaCyc:RXN0-2382 +xref: RHEA:26434 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0052685 +name: perillic acid-CoA ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA." [KEGG_REACTION:R06368] +synonym: "perillic acid:CoA ligase (ADP-forming) activity" EXACT [] +synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] +xref: EC:6.2.1.- +xref: KEGG_REACTION:R06367 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0052686 +name: perillic acid-CoA ligase (AMP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA." [KEGG_REACTION:R06368] +synonym: "perillic acid:CoA ligase (AMP-forming) activity" EXACT [] +synonym: "perillyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0731] +xref: KEGG_REACTION:R06368 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0052687 +name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06396] +synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] +xref: KEGG_REACTION:R06396 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0052688 +name: (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [KEGG_REACTION:R06515] +synonym: "3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity" BROAD [UM-BBD_reactionID:r0737] +xref: KEGG_REACTION:R06515 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0052689 +name: carboxylic ester hydrolase activity +namespace: molecular_function +alt_id: GO:0004091 +alt_id: GO:0004302 +alt_id: GO:0004759 +alt_id: GO:0016789 +def: "Catalysis of the hydrolysis of a carboxylic ester bond." [EC:3.1.1.-, EC:3.1.1.1, GOC:curators] +subset: goslim_drosophila +synonym: "ali-esterase activity" NARROW [EC:3.1.1.1] +synonym: "alpha-carboxylesterase activity" NARROW [EC:3.1.1.1] +synonym: "B-esterase activity" RELATED [EC:3.1.1.1] +synonym: "carboxyesterase activity" RELATED [EC:3.1.1.1] +synonym: "carboxyl ester hydrolase activity" RELATED [EC:3.1.1.1] +synonym: "carboxylate esterase activity" RELATED [EC:3.1.1.1] +synonym: "carboxylesterase activity" EXACT [] +synonym: "carboxylic acid esterase activity" EXACT [] +synonym: "carboxylic esterase activity" RELATED [EC:3.1.1.1] +synonym: "cocaine esterase activity" NARROW [EC:3.1.1.1] +synonym: "esterase A" NARROW [EC:3.1.1.1] +synonym: "esterase B" NARROW [EC:3.1.1.1] +synonym: "nonspecific carboxylesterase activity" RELATED [EC:3.1.1.1] +synonym: "procaine esterase activity" NARROW [EC:3.1.1.1] +synonym: "serine esterase activity" NARROW [] +synonym: "triacetin esterase" NARROW [EC:3.1.1.1] +synonym: "vitamin A esterase" NARROW [EC:3.1.1.1] +xref: EC:3.1.1.1 +xref: KEGG_REACTION:R00630 +xref: MetaCyc:CARBOXYLESTERASE-RXN +xref: Reactome:R-HSA-5693691 "CES1 trimer.CES2 hydrolyse COCN to BEG" +xref: Reactome:R-HSA-8937442 "CES3 hydrolyses CHEST to CHOL and LCFA(-)" +xref: Reactome:R-HSA-9619024 "CES1trimer hydrolyses ACEI pro-drugs to ACEIs" +xref: RHEA:21164 +xref: UM-BBD_reactionID:r1025 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0052690 +name: trichloro-p-hydroquinone reductive dehalogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl." [PMID:1459949, RHEA:56832, UM-BBD_reactionID:r0315] +synonym: "pentaerythritol tetranitrate reductase activity" RELATED [UM-BBD_enzymeID:e0028] +synonym: "tetrachlorohydroquinone reductive dehalogenase activity" RELATED [UM-BBD_enzymeID:e0251] +synonym: "trichlorohydroquinone reductive dehalogenase activity" EXACT [] +synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] +xref: RHEA:56832 +xref: UM-BBD_reactionID:r0315 +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0052691 +name: UDP-arabinopyranose mutase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose." [EC:5.4.99.30, RHEA:28350] +synonym: "UDP-arabinopyranose pyranomutase activity" EXACT systematic_synonym [EC:5.4.99.30] +synonym: "UDP-L-Ara mutase activity" RELATED [EC:5.4.99.30] +synonym: "UDP-L-arabinopyranose furanomutase activity" RELATED [EC:5.4.99.30] +synonym: "UDP-L-arabinose mutase activity" RELATED [EC:5.4.99.30] +synonym: "uridine-diphosphate-L-arabinose mutase activity" RELATED [EC:5.4.99.30] +xref: EC:5.4.99.30 +xref: MetaCyc:RXN-11552 +xref: RHEA:28350 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0052692 +name: raffinose alpha-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose." [MetaCyc:RXN-11502] +synonym: "alkaline alpha-galactosidase activity" BROAD [] +synonym: "raffinose galactohydrolase activity" BROAD [] +synonym: "raffinose-specific alkaline alpha-galactosidase activity" EXACT [PMID:20739305] +xref: EC:3.2.1.22 +xref: KEGG_REACTION:R01103 +xref: MetaCyc:RXN-11502 +is_a: GO:0004557 ! alpha-galactosidase activity + +[Term] +id: GO:0052693 +name: epoxyqueuosine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant." [PMID:21502530, RHEA:32159] +xref: EC:1.17.99.6 +xref: RHEA:32159 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0052694 +name: jasmonoyl-isoleucine-12-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O." [MetaCyc:RXN-12421, PMID:21576464] +xref: MetaCyc:RXN-12421 +xref: RHEA:54808 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052695 +name: cellular glucuronidation +namespace: biological_process +def: "The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor." [GOC:BHF] +synonym: "cellular glucuronide biosynthesis" EXACT [] +synonym: "cellular glucuronide biosynthetic process" EXACT [] +synonym: "cellular glucuronoside biosynthesis" EXACT [] +synonym: "cellular glucuronoside biosynthetic process" EXACT [] +is_a: GO:0019585 ! glucuronate metabolic process + +[Term] +id: GO:0052696 +name: flavonoid glucuronidation +namespace: biological_process +def: "The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor." [GOC:BHF, PMID:20056724] +synonym: "flavonoid glucuronide biosynthesis" EXACT [] +synonym: "flavonoid glucuronide biosynthetic process" EXACT [] +synonym: "flavonoid glucuronoside biosynthesis" EXACT [] +synonym: "flavonoid glucuronoside biosynthetic process" EXACT [] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:0052697 +name: xenobiotic glucuronidation +namespace: biological_process +def: "The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion." [GOC:BHF, PMID:20056724] +synonym: "phase II metabolism" NARROW [] +is_a: GO:0006805 ! xenobiotic metabolic process +is_a: GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:0052698 +name: ergothioneine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] +synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate metabolic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine metabolic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine metabolism" EXACT [CHEBI:4828] +synonym: "ergothioneine metabolism" EXACT [] +is_a: GO:0000096 ! sulfur amino acid metabolic process +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:0052699 +name: ergothioneine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] +synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine anabolism" EXACT [] +synonym: "2-mercaptoergothioneine trimethylbetaine biosynthesis" EXACT [] +synonym: "2-mercaptoergothioneine trimethylbetaine biosynthetic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine formation" EXACT [] +synonym: "2-mercaptoergothioneine trimethylbetaine synthesis" EXACT [] +synonym: "ergothioneine anabolism" EXACT [] +synonym: "ergothioneine biosynthesis" EXACT [] +synonym: "ergothioneine formation" EXACT [] +synonym: "ergothioneine synthesis" EXACT [] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0052698 ! ergothioneine metabolic process +is_a: GO:0052703 ! cellular modified histidine biosynthetic process + +[Term] +id: GO:0052700 +name: ergothioneine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties." [Wikipedia:Ergothioneine] +synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine breakdown" EXACT [] +synonym: "2-mercaptoergothioneine trimethylbetaine catabolic process" EXACT [CHEBI:4828] +synonym: "2-mercaptoergothioneine trimethylbetaine catabolism" EXACT [] +synonym: "2-mercaptoergothioneine trimethylbetaine degradation" EXACT [] +synonym: "ergothioneine breakdown" EXACT [] +synonym: "ergothioneine catabolism" EXACT [] +synonym: "ergothioneine degradation" EXACT [] +is_a: GO:0000098 ! sulfur amino acid catabolic process +is_a: GO:0006579 ! amino-acid betaine catabolic process +is_a: GO:0052698 ! ergothioneine metabolic process +is_a: GO:0052702 ! cellular modified histidine catabolic process + +[Term] +id: GO:0052701 +name: cellular modified histidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] +synonym: "cellular histidine derivative metabolic process" EXACT [] +synonym: "cellular histidine derivative metabolism" EXACT [] +synonym: "cellular modified histidine metabolism" EXACT [] +synonym: "histidine derivative metabolic process" EXACT [] +synonym: "modified histidine metabolic process" EXACT [] +synonym: "modified histidine metabolism" EXACT [] +is_a: GO:0006575 ! cellular modified amino acid metabolic process + +[Term] +id: GO:0052702 +name: cellular modified histidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] +synonym: "cellular histidine derivative breakdown" EXACT [] +synonym: "cellular histidine derivative catabolic process" EXACT [] +synonym: "cellular histidine derivative catabolism" EXACT [] +synonym: "cellular histidine derivative degradation" EXACT [] +synonym: "cellular modified histidine breakdown" EXACT [] +synonym: "cellular modified histidine catabolism" EXACT [] +synonym: "cellular modified histidine degradation" EXACT [] +synonym: "histidine derivative catabolic process" EXACT [] +synonym: "modified histidine catabolic process" EXACT [] +synonym: "modified histidine catabolism" EXACT [] +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:0052703 +name: cellular modified histidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai] +synonym: "cellular histidine derivative anabolism" EXACT [] +synonym: "cellular histidine derivative biosynthesis" EXACT [] +synonym: "cellular histidine derivative biosynthetic process" EXACT [] +synonym: "cellular histidine derivative formation" EXACT [] +synonym: "cellular histidine derivative synthesis" EXACT [] +synonym: "cellular modified histidine anabolism" EXACT [] +synonym: "cellular modified histidine biosynthesis" EXACT [] +synonym: "cellular modified histidine formation" EXACT [] +synonym: "cellular modified histidine synthesis" EXACT [] +synonym: "histidine derivative biosynthetic process" EXACT [] +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:0052704 +name: ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide +namespace: biological_process +def: "The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate." [PMID:4276459, PMID:5484456] +synonym: "ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" BROAD [] +xref: Wikipedia:Ergothioneine +is_a: GO:0052699 ! ergothioneine biosynthetic process + +[Term] +id: GO:0052705 +name: methylhistidine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine." [EC:2.1.1.44] +synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] +synonym: "methylhistidine methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity" RELATED [EC:2.1.1.44] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0052706 +name: histidine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44] +synonym: "histidine methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity" RELATED [EC:2.1.1.44] +synonym: "S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity" RELATED [EC:2.1.1.44] +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0052707 +name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine +namespace: biological_process +def: "The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [EC:2.1.1.44] +synonym: "hercynine biosynthesis from histidine" EXACT [] +synonym: "histidine betaine biosynthesis from histidine" EXACT [] +synonym: "histidine catabolic process to hercynine" EXACT [] +synonym: "histidine catabolism to hercynine" EXACT [] +synonym: "histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine" EXACT [] +xref: KEGG_REACTION:R01169 +is_a: GO:0006548 ! histidine catabolic process +is_a: GO:0052709 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process + +[Term] +id: GO:0052708 +name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators] +synonym: "hercynine metabolic process" EXACT [CHEBI:15781] +synonym: "hercynine metabolism" EXACT [CHEBI:15781] +synonym: "histidine betaine metabolic process" EXACT [CHEBI:15781] +synonym: "histidine betaine metabolism" EXACT [CHEBI:15781] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolism" EXACT [] +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0052709 +name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators] +synonym: "hercynine anabolism" EXACT [] +synonym: "hercynine biosynthesis" EXACT [] +synonym: "hercynine biosynthetic process" EXACT [] +synonym: "hercynine formation" EXACT [] +synonym: "hercynine synthesis" EXACT [] +synonym: "histidine betaine anabolism" EXACT [] +synonym: "histidine betaine biosynthesis" EXACT [] +synonym: "histidine betaine biosynthetic process" EXACT [] +synonym: "histidine betaine formation" EXACT [] +synonym: "histidine betaine synthesis" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine anabolism" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine formation" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine synthesis" EXACT [] +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0052710 +name: N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine, also known as histidine betaine or hercynine, a trimethylated derivative of histidine." [GOC:curators] +synonym: "hercynine breakdown" EXACT [] +synonym: "hercynine catabolic process" EXACT [] +synonym: "hercynine catabolism" EXACT [] +synonym: "hercynine degradation" EXACT [] +synonym: "histidine betaine breakdown" EXACT [] +synonym: "histidine betaine catabolic process" EXACT [] +synonym: "histidine betaine catabolism" EXACT [] +synonym: "histidine betaine degradation" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine breakdown" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine degradation" EXACT [] +is_a: GO:0006579 ! amino-acid betaine catabolic process +is_a: GO:0052708 ! N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0052711 +name: obsolete ergothioneine biosynthesis from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine +namespace: biological_process +def: "OBSOLETE. The pathway resulting in the formation of ergothioneine from N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine)." [KEGG_REACTION:R04878] +comment: The reason for obsoletion is that this term does not provide a useful distinction from its parent, GO:0052704 (because that trimethyl-His yada is present in both pathways) +synonym: "ergothioneine biosynthesis from hercynine" EXACT [] +synonym: "ergothioneine biosynthesis from histidine betaine" EXACT [] +synonym: "hercynine catabolism to ergothioneine" EXACT [] +synonym: "histidine betaine catabolism to ergothioneine" EXACT [] +synonym: "N-alpha,N-alpha,N-alpha-trimethyl-L-histidine catabolism to ergothioneine" EXACT [] +xref: KEGG_REACTION:R04878 +is_obsolete: true + +[Term] +id: GO:0052712 +name: inositol phosphosphingolipid phospholipase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol." [GOC:ai] +is_a: GO:0004629 ! phospholipase C activity + +[Term] +id: GO:0052713 +name: inositol phosphorylceramide phospholipase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol." [GOC:ai] +is_a: GO:0052712 ! inositol phosphosphingolipid phospholipase activity + +[Term] +id: GO:0052714 +name: mannosyl-inositol phosphorylceramide phospholipase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol." [GOC:ai] +is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity + +[Term] +id: GO:0052715 +name: mannosyl-diinositol phosphorylceramide phospholipase activity +namespace: molecular_function +def: "Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol." [GOC:ai] +is_a: GO:0052713 ! inositol phosphorylceramide phospholipase activity + +[Term] +id: GO:0052716 +name: hydroquinone:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O." [EC:1.10.3.2] +synonym: "benzenediol:oxygen oxidoreductase activity" BROAD [] +synonym: "laccase reaction" BROAD [] +synonym: "p-diphenol:oxygen oxidoreductase activity" EXACT [] +xref: EC:1.10.3.2 +xref: KEGG_REACTION:R00083 +xref: MetaCyc:LACCASE-RXN +xref: RHEA:11276 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0052717 +name: tRNA-specific adenosine-34 deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule." [PMID:17875641] +synonym: "tRNA(Ala)-A34 deaminase activity" EXACT [] +is_a: GO:0008251 ! tRNA-specific adenosine deaminase activity + +[Term] +id: GO:0052718 +name: tRNA-specific adenosine-34 deaminase complex +namespace: cellular_component +def: "A protein complex that possesses tRNA-specific adenosine-34 deaminase activity. In eukaryotes the complex is a heterodimer; the subunits are known as Tad2p and Tad3p in yeasts and Adat2 and Adat3 in human." [PMID:17875641] +synonym: "tRNA-A34 deaminase complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0052719 +name: apurinic/apyrimidinic endoribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends." [PMID:19401441] +synonym: "abasic endoribonuclease activity" EXACT [] +synonym: "AP endoribonuclease activity" EXACT [] +synonym: "apurinic endoribonuclease activity" NARROW [] +synonym: "apyrimidinic endoribonuclease activity" NARROW [] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0052720 +name: class II DNA-(apurinic or apyrimidinic site) endonuclease activity +namespace: molecular_function +alt_id: GO:0140079 +def: "Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441] +comment: Class II AP endonuclease is a nuclease, but not Class I, III and IV. +synonym: "class II DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity +is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0052721 +name: regulation of apurinic/apyrimidinic endodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends." [PMID:19401441] +synonym: "regulation of abasic endodeoxyribonuclease activity" EXACT [] +synonym: "regulation of AP endodeoxyribonuclease activity" EXACT [] +synonym: "regulation of apurinic endodeoxyribonuclease activity" NARROW [] +synonym: "regulation of apyrimidinic endodeoxyribonuclease activity" NARROW [] +is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity + +[Term] +id: GO:0052722 +name: fatty acid in-chain hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O." [MetaCyc:RXN-12186] +xref: MetaCyc:RXN-12186 +xref: RHEA:45084 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0052723 +name: inositol hexakisphosphate 1-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179, RHEA:37459] +xref: EC:2.7.4.21 +xref: KEGG_REACTION:R05799 +xref: MetaCyc:RXN-10972 +xref: RHEA:37459 +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0052724 +name: inositol hexakisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] +xref: EC:2.7.4.21 +xref: MetaCyc:RXN-10971 +is_a: GO:0000828 ! inositol hexakisphosphate kinase activity + +[Term] +id: GO:0052725 +name: inositol-1,3,4-trisphosphate 6-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 6-kinase activity" BROAD [] +synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity" RELATED [EC:2.7.1.127] +synonym: "inositol 1,3,4-trisphosphate 6-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 6-kinase activity" BROAD [] +synonym: "ins(1,3,4)P(3) 6-kinase activity" RELATED [EC:2.7.1.127] +synonym: "Ins(1,3,4)P3 6-kinase activity" RELATED [EC:2.7.1.127] +synonym: "IP3 6-kinase activity" BROAD [EC:2.7.1.127] +xref: EC:2.7.1.159 +xref: MetaCyc:2.7.1.133-RXN +xref: Reactome:R-HSA-1855197 "I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol" +xref: Reactome:R-HSA-2267372 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,6-P4" +xref: RHEA:20940 +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0052726 +name: inositol-1,3,4-trisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.134] +synonym: "1D-myo-inositol-trisphosphate 5-kinase activity" BROAD [] +synonym: "ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.127] +synonym: "inositol 1,3,4-trisphosphate 5-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 5-kinase activity" BROAD [] +synonym: "ins(1,3,4)P(3) 5-kinase activity" RELATED [EC:2.7.1.127] +synonym: "Ins(1,3,4)P3 5-kinase activity" RELATED [EC:2.7.1.127] +synonym: "IP3 5-kinase activity" BROAD [EC:2.7.1.127] +xref: EC:2.7.1.159 +xref: KEGG_REACTION:R03428 +xref: MetaCyc:2.7.1.139-RXN +xref: Reactome:R-HSA-1855172 "I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol" +xref: Reactome:R-HSA-994140 "ITPK1 converts Ins-1,3,4-P3 to Ins-1,3,4,5-P4" +xref: RHEA:13253 +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0052727 +name: capsanthin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: antheraxanthin = capsanthin." [EC:5.3.99.8] +synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8] +synonym: "CCS" RELATED [EC:5.3.99.8] +synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] +xref: EC:5.3.99.8 +xref: MetaCyc:RXN-7947 +xref: RHEA:17373 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0052728 +name: capsorubin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: violaxanthin = capsorubin." [EC:5.3.99.8] +synonym: "capsanthin-capsorubin synthase activity" BROAD [EC:5.3.99.8] +synonym: "CCS" RELATED [EC:5.3.99.8] +synonym: "ketoxanthophyll synthase activity" BROAD [EC:5.3.99.8] +synonym: "violaxanthin-capsorubin isomerase (ketone-forming) activity" RELATED [EC:5.3.99.8] +xref: EC:5.3.99.8 +xref: MetaCyc:RXN-7946 +xref: RHEA:21752 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0052729 +name: dimethylglycine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine." [EC:2.1.1.157] +synonym: "ApDMT" RELATED [EC:2.1.1.157] +synonym: "S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity" RELATED [EC:2.1.1.157] +xref: EC:2.1.1.157 +xref: EC:2.1.1.161 +xref: EC:2.1.1.162 +xref: KEGG_REACTION:R07244 +xref: MetaCyc:R482-RXN +xref: MetaCyc:RXN-9680 +xref: RHEA:10072 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0052730 +name: sarcosine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine." [EC:2.1.1.157] +synonym: "S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity" RELATED [EC:2.1.1.157] +synonym: "SDMT" RELATED [EC:2.1.1.157] +xref: EC:2.1.1.156 +xref: EC:2.1.1.157 +xref: EC:2.1.1.162 +xref: KEGG_REACTION:R07243 +xref: MetaCyc:R481-RXN +xref: MetaCyc:RXN-7042 +xref: MetaCyc:RXN-9679 +xref: RHEA:15453 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0052731 +name: phosphocholine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: choline phosphate + H2O = choline + phosphate." [EC:3.1.3.75] +synonym: "3X11A" RELATED [EC:3.1.3.75] +synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] +synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75] +xref: EC:3.1.3.75 +xref: KEGG_REACTION:R06871 +xref: MetaCyc:RXN-5647 +xref: Reactome:R-HSA-1483159 "PCho is dephosphorylated to Cho by PHOSPHO1" +xref: RHEA:10492 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0052732 +name: phosphoethanolamine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate." [EC:3.1.3.75] +synonym: "3X11A" RELATED [EC:3.1.3.75] +synonym: "PHOSPHO1" RELATED [EC:3.1.3.75] +synonym: "phosphoethanolamine phosphohydrolase activity" RELATED [EC:3.1.3.75] +xref: EC:3.1.3.75 +xref: KEGG_REACTION:R06870 +xref: MetaCyc:RXN-7948 +xref: Reactome:R-HSA-1483096 "PETA is dephosphorylated to ETA by PHOSPHO1" +xref: RHEA:16089 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0052733 +name: quinate 3-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+." [RHEA:18425] +synonym: "quinate:NADP 3-oxidoreductase activity" RELATED [EC:1.1.1.24] +synonym: "quinate:NADP(+) 3-oxidoreductase activity" RELATED [EC:1.1.1.24] +synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24] +xref: EC:1.1.1.282 +xref: KEGG_REACTION:R06846 +xref: RHEA:18425 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052734 +name: shikimate 3-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+." [RHEA:17741] +synonym: "3-dehydroshikimate reductase activity" RELATED [EC:1.1.1.25] +synonym: "3-dehydroshikimic reductase activity" RELATED [EC:1.1.1.25] +synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25] +synonym: "DHS reductase activity" BROAD [EC:1.1.1.25] +synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25] +synonym: "shikimate:NAD(P)(+) 3-oxidoreductase activity" RELATED [EC:1.1.1.25] +synonym: "shikimate:NAD(P)(+) oxidoreductase activity" BROAD [EC:1.1.1.25] +xref: EC:1.1.1.282 +xref: KEGG_REACTION:R06847 +xref: RHEA:17741 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052735 +name: tRNA (cytosine-3-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine." [PMID:21518804, PMID:21518805] +synonym: "S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity" EXACT [] +synonym: "S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity" EXACT [] +synonym: "transfer ribonucleate cytosine 3-methyltransferase activity" EXACT [] +synonym: "tRNA (cytosine 3)-methyltransferase activity" EXACT [] +synonym: "tRNA cytosine 3-methyltransferase activity" EXACT [] +synonym: "tRNA cytosine-3-methyltransferase activity" EXACT [] +is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0052736 +name: beta-glucanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds." [Wikipedia:Beta-glucan] +synonym: "beta-D-glucanase activity" EXACT [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052737 +name: pyruvate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2." [EC:1.2.5.1] +synonym: "pyruvate dehydrogenase activity" BROAD [EC:1.2.5.1] +synonym: "pyruvate:ubiquinone oxidoreductase activity" EXACT systematic_synonym [EC:1.2.5.1] +synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.5.1] +synonym: "pyruvic dehydrogenase activity" BROAD [EC:1.2.5.1] +xref: EC:1.2.5.1 +xref: KEGG_REACTION:R03145 +xref: MetaCyc:RXN-11496 +xref: RHEA:27405 +is_a: GO:0052738 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor + +[Term] +id: GO:0052738 +name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound." [EC:1.2.5.-] +xref: EC:1.2.5.- +is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors + +[Term] +id: GO:0052739 +name: phosphatidylserine 1-acylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid." [KEGG_REACTION:R04034] +synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32] +xref: EC:3.1.1.32 +xref: KEGG_REACTION:R04034 +xref: Reactome:R-HSA-8869425 "PLA1A hydrolyses PS to 2-acyl LPS" +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052740 +name: 1-acyl-2-lysophosphatidylserine acylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate." [BRENDA:3.1.1.32] +synonym: "phosphatidylserine-specific phospholipase A1 activity" BROAD [EC:3.1.1.32] +xref: EC:3.1.1.32 +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052741 +name: (R)-limonene 6-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+." [EC:1.14.14.53, RHEA:18957] +synonym: "(+)-limonene 6-monooxygenase activity" RELATED [EC:1.14.14.53] +synonym: "(+)-limonene-6-hydroxylase activity" RELATED [EC:1.14.14.53] +synonym: "(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT systematic_synonym [EC:1.14.14.53] +xref: EC:1.14.14.53 +xref: KEGG_REACTION:R06119 +xref: MetaCyc:1.14.13.84-RXN +xref: RHEA:18957 +is_a: GO:0019113 ! limonene monooxygenase activity + +[Term] +id: GO:0052742 +name: phosphatidylinositol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate." [GOC:ai] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0052743 +name: inositol tetrakisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate." [GOC:ai] +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0052744 +name: phosphatidylinositol monophosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate." [GOC:ai] +is_a: GO:0052866 ! phosphatidylinositol phosphate phosphatase activity + +[Term] +id: GO:0052745 +name: inositol phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." [GOC:ai] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0052746 +name: inositol phosphorylation +namespace: biological_process +def: "The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms." [ISBN:0198506732] +synonym: "inositol and derivative phosphorylation" RELATED [] +synonym: "myo-inositol and derivative phosphorylation" RELATED [] +synonym: "myo-inositol phosphorylation" NARROW [] +is_a: GO:0006020 ! inositol metabolic process +is_a: GO:0046835 ! carbohydrate phosphorylation + +[Term] +id: GO:0052747 +name: sinapyl alcohol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+." [GOC:mengo_curators, MetaCyc:RXN-1125] +synonym: "sinapyl-alcohol dehydrogenase activity" RELATED [EC:1.1.1.195] +synonym: "sinapyl-alcohol:NADP+ oxidoreductase activity" EXACT systematic_synonym [EC:1.1.1.195] +xref: EC:1.1.1.195 +xref: KEGG_REACTION:R03918 +xref: MetaCyc:RXN-1125 +xref: RHEA:45704 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052748 +name: baicalin beta-D-glucuronidase activity +namespace: molecular_function +def: "Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate." [GOC:mengo_curators, RHEA:28130] +synonym: "5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity" RELATED [EC:3.2.1.167] +synonym: "baicalinase activity" BROAD [EC:3.2.1.167] +xref: EC:3.2.1.167 +xref: KEGG_REACTION:R09533 +xref: MetaCyc:RXN-11760 +xref: RHEA:28130 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052749 +name: glucose-6-phosphate dehydrogenase (coenzyme F420) activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420." [EC:1.1.98.2, GOC:mengo_curators, RHEA:27294] +synonym: "coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity" RELATED [EC:1.1.98.2] +synonym: "D-glucose-6-phosphate:F420 1-oxidoreductase activity" EXACT systematic_synonym [EC:1.1.98.2] +synonym: "F420-dependent glucose-6-phosphate dehydrogenase activity" RELATED [EC:1.1.98.2] +xref: EC:1.1.98.2 +xref: KEGG_REACTION:R09550 +xref: MetaCyc:RXN-11283 +xref: RHEA:27294 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0052750 +name: reactive-black-5:hydrogen-peroxide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O." [KEGG_REACTION:R07612, MetaCyc:RXN-8666] +synonym: "versatile peroxidase activity" BROAD [EC:1.11.1.16] +xref: EC:1.11.1.16 +xref: KEGG_REACTION:R07612 +xref: MetaCyc:RXN-8666 +xref: RHEA:22396 +is_a: GO:0004601 ! peroxidase activity + +[Term] +id: GO:0052751 +name: GDP-mannose hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate." [PMID:16766526] +synonym: "GDP-mannose pyrophosphatase activity" RELATED [PMID:16766526] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0052752 +name: reduced coenzyme F420:heterodisulfide oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH." [GOC:mengo_curators, PMID:9914308] +synonym: "coenzyme F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308] +synonym: "F420-dependent heterodisulfide oxidoreductase activity" EXACT [PMID:9914308] +synonym: "F420H2:heterodisulfide oxidoreductase activity" EXACT [] +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0052753 +name: propan-2-ol:coenzyme F420 oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420." [GOC:mengo_curators, PMID:15016352, PMID:1879431, PMID:8706724] +synonym: "F420-dependent propan-2-ol dehydrogenase activity" EXACT [] +synonym: "F420-dependent secondary alcohol dehydrogenase activity" BROAD [] +synonym: "isopropanol:coenzyme F420 oxidoreductase activity" EXACT [] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0052754 +name: GTP:coenzyme F420 guanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate." [GOC:mengo_curators, MetaCyc:MONOMER-13942, MetaCyc:RXN-9385] +synonym: "coenzyme F390-G synthetase activity" EXACT [] +synonym: "GTP:coenzyme F420 guanylyltransferase activity" EXACT [] +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0052755 +name: reduced coenzyme F420:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone." [GOC:mengo_curators, PMID:10971593, PMID:8055920] +synonym: "F420H2-dependent quinone oxidoreductase activity" EXACT [] +synonym: "F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity" EXACT [] +synonym: "F420H2:quinone oxidoreductase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0052756 +name: chitobiose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units." [GOC:mengo_curators, PMID:15274915, Wikipedia:chitobiose] +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0052757 +name: chondroitin hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]." [GOC:mengo_curators, PMID:18390555] +synonym: "chondroitin endo-beta-galactosaminidase activity" EXACT [PMID:18390555] +is_a: GO:0033931 ! endogalactosaminidase activity + +[Term] +id: GO:0052758 +name: coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1065] +synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity" EXACT [] +synonym: "TNP reductase activity" BROAD [] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r1065 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0052759 +name: coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, UM-BBD_reactionID:r1066] +synonym: "coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity" EXACT [] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r1066 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0052760 +name: coenzyme F420-dependent 2,4-dinitrophenol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction." [GOC:mengo_curators, PMID:11995829, UM-BBD_reactionID:r1071] +synonym: "coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity" EXACT [] +synonym: "DNP reductase activity" BROAD [] +xref: EC:1.3.99.- +xref: UM-BBD_reactionID:r1071 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0052761 +name: exo-1,4-beta-D-glucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units." [EC:3.2.1.165, GOC:mengo_curators, MetaCyc:3.2.1.165-RXN] +synonym: "chitosan exo-1,4-beta-D-glucosaminidase activity" EXACT [KEGG_REACTION:R08715] +synonym: "chitosan glucosaminohydrolase activity" EXACT [KEGG_REACTION:R08715] +synonym: "exo-beta-D-glucosaminidase activity" RELATED [EC:3.2.1.165] +synonym: "exochitosanase activity" RELATED [EC:3.2.1.165] +xref: EC:3.2.1.165 +xref: KEGG_REACTION:R08715 +xref: MetaCyc:3.2.1.165-RXN +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052762 +name: gellan lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha)." [GOC:mengo_curators, MetaCyc:RXN-12269] +xref: EC:4.2.2.25 +xref: MetaCyc:RXN-12269 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0052763 +name: ulvan lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end." [GOC:mengo_curators, PMID:9468631] +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0052764 +name: exo-oligoalginate lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [GOC:mengo_curators, PMID:20925655] +xref: EC:4.2.2.26 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0052765 +name: reduced coenzyme F420 oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O." [GOC:mengo_curators, PMID:15340796] +synonym: "coenzyme F420H2 oxidase activity" EXACT [] +synonym: "F420H2 oxidase activity" EXACT [] +synonym: "F420H2:oxygen oxidoreductase activity" EXACT [] +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0052766 +name: mannoside alpha-1,4-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [GOC:mengo_curators, PMID:20081828] +synonym: "alpha-1,4-exomannosidase activity" BROAD [] +synonym: "alpha-1,4-mannosidase activity" BROAD [] +synonym: "mannoside alpha-1,4-exomannosidase activity" EXACT [] +synonym: "mannoside exo-alpha-1,4-mannosidase activity" EXACT [] +is_a: GO:0004559 ! alpha-mannosidase activity + +[Term] +id: GO:0052767 +name: mannosyl-oligosaccharide 1,6-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081] +synonym: "1,6-alpha-mannosidase activity" BROAD [] +synonym: "1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] +synonym: "alpha-1,6-mannosidase activity" BROAD [] +synonym: "alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0052768 +name: mannosyl-oligosaccharide 1,3-alpha-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide." [GOC:mengo_curators, PMID:1849817, PMID:2338081] +synonym: "1,3-alpha-mannosidase activity" BROAD [] +synonym: "1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] +synonym: "alpha-1,3-mannosidase activity" BROAD [] +synonym: "alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [] +xref: EC:3.1.1.- +is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity + +[Term] +id: GO:0052769 +name: beta-6-sulfate-N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative." [GOC:mengo_curators, PMID:15716424] +synonym: "beta-6-SO3-N-acetylglucosaminidase activity" BROAD [] +synonym: "exosulfoglycosidase activity" BROAD [] +synonym: "sulfoglycosidase activity" BROAD [] +synonym: "sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity" EXACT [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052770 +name: coenzyme F390-A hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911] +synonym: "8-hydroxyadenylylated-coenzyme F420 hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0052771 +name: coenzyme F390-G hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420." [GOC:mengo_curators, PMID:8536708, PMID:9352911] +synonym: "8-hydroxyguanylylated-coenzyme F420 hydrolase activity" EXACT [] +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0052772 +name: brefeldin A esterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone." [GOC:mengo_curators, PMID:10201402, PMID:8106385] +synonym: "BFA esterase activity" BROAD [] +synonym: "brefeldin A hydrolase activity" EXACT [] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052773 +name: diacetylchitobiose deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc)." [GOC:bf, GOC:mengo_curators, MetaCyc:RXN-12543, PMID:15136574, PMID:16232910, PMID:16736587] +comment: In this reaction N,N'-diacetylchitobiose is deacetylated at the non-reducing residue to produce 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). This is in contrast to EC:3.5.1.105 in which N,N'-diacetylchitobiose is deacetylated at the reducing residue to produce 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine (GlcNAc-GlcN). For the latter reaction, see GO:0036311. +synonym: "N,N'-diacetylchitobiose deacetylase (nonreducing end)" EXACT [MetaCyc:RXN-12543] +xref: MetaCyc:RXN-12543 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0052774 +name: glucosyl-N-acetylglucosamine glucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine." [GOC:mengo_curators, PMID:15136574, PMID:16232910, PMID:16736587] +is_a: GO:0015929 ! hexosaminidase activity + +[Term] +id: GO:0052775 +name: endo-1,3-alpha-L-rhamnosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain." [GOC:mengo_curators, PMID:10439404] +synonym: "endo-(1,3)-alpha-L-rhamnosidase activity" EXACT [] +synonym: "endo-(1->3)-alpha-L-rhamnosidase activity" EXACT [] +synonym: "endorhamnosidase activity" BROAD [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052776 +name: diacetylchitobiose catabolic process to glucosamine and acetate +namespace: biological_process +def: "The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate." [GOC:bf, GOC:mengo_curators, MetaCyc:PWY-6855, PMID:15136574, PMID:16232910, PMID:16736587] +is_a: GO:0006041 ! glucosamine metabolic process +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0052777 ! diacetylchitobiose catabolic process + +[Term] +id: GO:0052777 +name: diacetylchitobiose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products." [PMID:22797760] +synonym: "diacetylchitobiose catabolism" EXACT [GOC:obol] +is_a: GO:0052778 ! diacetylchitobiose metabolic process +is_a: GO:0052782 ! amino disaccharide catabolic process + +[Term] +id: GO:0052778 +name: diacetylchitobiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diacetylchitobiose, the N,N'-diacetylated derivative of chitobiose." [PMID:22797760] +synonym: "diacetylchitobiose metabolism" EXACT [GOC:obol] +is_a: GO:0052779 ! amino disaccharide metabolic process + +[Term] +id: GO:0052779 +name: amino disaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [GOC:curators] +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0052780 +name: chitobiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [GOC:curators] +is_a: GO:0052779 ! amino disaccharide metabolic process + +[Term] +id: GO:0052781 +name: chitobiose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine." [GOC:curators] +is_a: GO:0052782 ! amino disaccharide catabolic process + +[Term] +id: GO:0052782 +name: amino disaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions." [GOC:curators] +is_a: GO:0052779 ! amino disaccharide metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0052783 +name: reuteran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [PMID:15256553, PMID:16000808] +is_a: GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0052784 +name: reuteran biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages." [GOC:mengo_curators, PMID:15256553, PMID:16000808] +synonym: "reuteransucrase-mediated reuteran biosynthesis" NARROW [] +is_a: GO:0030979 ! alpha-glucan biosynthetic process +is_a: GO:0052783 ! reuteran metabolic process + +[Term] +id: GO:0052785 +name: cellulose catabolism by endo-processive cellulases +namespace: biological_process +def: "The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments." [GOC:mengo_curators, PMID:18035374] +synonym: "endo-processive cellulase activity" RELATED [] +is_a: GO:0030245 ! cellulose catabolic process + +[Term] +id: GO:0052786 +name: alpha-linked polysaccharide catabolism to maltotriose +namespace: biological_process +def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose." [GOC:mengo_curators, PMID:7511484, PMID:9406414] +synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltotriose" EXACT [] +synonym: "maltotriose-forming alpha-amylase activity" RELATED [] +is_a: GO:0000272 ! polysaccharide catabolic process + +[Term] +id: GO:0052787 +name: alpha-linked polysaccharide catabolism to maltopentaose +namespace: biological_process +def: "The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose." [GOC:mengo_curators, PMID:7511484, PMID:9406414] +synonym: "alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose" EXACT [] +synonym: "maltopentaose-forming alpha-amylase activity" RELATED [] +is_a: GO:0000272 ! polysaccharide catabolic process + +[Term] +id: GO:0052788 +name: d-4,5 unsaturated beta-glucuronyl hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue." [GOC:mengo_curators, PMID:12729728] +synonym: "unsaturated beta-glucuronyl hydrolase activity" EXACT [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052789 +name: mannan 1,3-beta-mannosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose." [EC:3.2.1.78, GOC:mengo_curators] +synonym: "1,3-beta-D-mannan mannanohydrolase activity" RELATED [EC:3.2.1.78] +synonym: "beta-1,3-mannan 3-mannanohydrolase activity" RELATED [EC:3.2.1.78] +synonym: "exo-1,3-beta-mannanase activity" RELATED [EC:3.2.1.78] +synonym: "exo-1,3-mannanase activity" RELATED [EC:3.2.1.78] +synonym: "exo-beta-1,3-mannase activity" RELATED [EC:3.2.1.78] +is_a: GO:0004567 ! beta-mannosidase activity + +[Term] +id: GO:0052790 +name: chitooligosaccharide deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions." [GOC:mengo_curators, PMID:8421697, PMID:8986807] +xref: EC:3.5.1.- +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052791 +name: 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain." [GOC:mengo_curators, PMID:21247893] +synonym: "2-keto-3-deoxynononic acid sialidase activity" EXACT [] +is_a: GO:0016997 ! alpha-sialidase activity + +[Term] +id: GO:0052792 +name: endo-xylogalacturonan hydrolase activity +namespace: molecular_function +def: "Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position." [GOC:mengo_curators, PMID:10618200] +synonym: "endo-galacturonase activity" BROAD [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0052793 +name: pectin acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin." [GOC:mengo_curators, PMID:9218776] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052794 +name: exo-alpha-(2->3)-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] +synonym: "exo-alpha-(2,3)-sialidase activity" EXACT [] +synonym: "exo-alpha-2,3-sialidase activity" EXACT [] +xref: EC:3.2.1.18 +is_a: GO:0004308 ! exo-alpha-sialidase activity + +[Term] +id: GO:0052795 +name: exo-alpha-(2->6)-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] +synonym: "exo-alpha-(2,6)-sialidase activity" EXACT [] +synonym: "exo-alpha-2,6-sialidase activity" EXACT [] +xref: EC:3.2.1.18 +is_a: GO:0004308 ! exo-alpha-sialidase activity + +[Term] +id: GO:0052796 +name: exo-alpha-(2->8)-sialidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates." [EC:3.2.1.18, GOC:mengo_curators] +synonym: "exo-alpha-(2,8)-sialidase activity" EXACT [] +synonym: "exo-alpha-2,8-sialidase activity" EXACT [] +xref: EC:3.2.1.18 +is_a: GO:0004308 ! exo-alpha-sialidase activity + +[Term] +id: GO:0052797 +name: 4-O-methyl-glucuronoyl methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]." [GOC:mengo_curators, PMID:16876163] +synonym: "glucuronoyl esterase activity" BROAD [PMID:16876163] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052798 +name: beta-galactoside alpha-2,3-sialyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor." [GOC:mengo_curators, PMID:7826016, PMID:8405811] +synonym: "trans-sialidase activity" BROAD [] +is_a: GO:0008373 ! sialyltransferase activity + +[Term] +id: GO:0052799 +name: coenzyme F420-dependent bicyclic nitroimidazole catabolic process +namespace: biological_process +def: "The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates." [GOC:mengo_curators, PMID:16387854, PMID:19039139] +synonym: "coenzyme F420-dependent nitroimidazole breakdown" EXACT [] +synonym: "coenzyme F420-dependent nitroimidazole catabolism" EXACT [] +synonym: "coenzyme F420-dependent nitroimidazole reduction" EXACT [] +synonym: "coenzyme F420-dependent nitroreductase activity" RELATED [] +is_a: GO:0052800 ! bicyclic nitroimidazole catabolic process + +[Term] +id: GO:0052800 +name: bicyclic nitroimidazole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole." [PMID:16387854, PMID:19039139] +synonym: "bicyclic nitroimidazole breakdown" EXACT [] +synonym: "bicyclic nitroimidazole catabolism" EXACT [] +synonym: "bicyclic nitroimidazole degradation" EXACT [] +is_a: GO:0052801 ! bicyclic nitroimidazole metabolic process +is_a: GO:0052804 ! nitroimidazole catabolic process + +[Term] +id: GO:0052801 +name: bicyclic nitroimidazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring." [PMID:16387854, PMID:19039139] +synonym: "bicyclic nitroimidazole metabolism" EXACT [] +is_a: GO:0052802 ! nitroimidazole metabolic process + +[Term] +id: GO:0052802 +name: nitroimidazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139] +synonym: "nitroimidazole metabolism" EXACT [] +is_a: GO:0052803 ! imidazole-containing compound metabolic process + +[Term] +id: GO:0052803 +name: imidazole-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators] +synonym: "imidazole metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0052804 +name: nitroimidazole catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring." [PMID:16387854, PMID:19039139] +synonym: "nitroimidazole breakdown" EXACT [] +synonym: "nitroimidazole catabolism" EXACT [] +synonym: "nitroimidazole degradation" EXACT [] +is_a: GO:0052805 ! imidazole-containing compound catabolic process + +[Term] +id: GO:0052805 +name: imidazole-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [GOC:curators] +synonym: "imidazole breakdown" EXACT [] +synonym: "imidazole catabolism" EXACT [] +synonym: "imidazole degradation" EXACT [] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0052803 ! imidazole-containing compound metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0052806 +name: sulfite reductase (coenzyme F420) activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:16048999] +synonym: "coenzyme F420-dependent sulfite reductase activity" EXACT [] +synonym: "coenzyme F420-sulfite reductase activity" EXACT [] +synonym: "hydrogen-sulfide:coenzyme F420 oxidoreductase activity" EXACT [] +synonym: "sulfite:reduced coenzyme F420 reductase activity" EXACT [] +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0052807 +name: aflatoxin reductase (coenzyme F420) activity +namespace: molecular_function +def: "Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:20807200] +synonym: "aflatoxin:coenzyme F420 oxidoreductase activity" EXACT [] +synonym: "aflatoxin:reduced coenzyme F420 reductase activity" EXACT [] +synonym: "coenzyme F420-aflatoxin reductase activity" EXACT [] +synonym: "coenzyme F420-dependent aflatoxin reductase activity" EXACT [] +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0052808 +name: reduced coenzyme F420:NADP+ oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420." [GOC:mengo_curators, PMID:11726492] +synonym: "coenzyme F420-dependent NADP oxidoreductase activity" EXACT [] +synonym: "coenzyme F420-dependent NADP reductase activity" EXACT [] +synonym: "F420H2:NADP oxidoreductase activity" EXACT [] +synonym: "F420H2:NADP+ oxidoreductase activity" EXACT [] +synonym: "NADP+:F420 oxidoreductase activity" EXACT [] +xref: EC:1.5.1.40 +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0052809 +name: acharan sulfate lyase activity +namespace: molecular_function +def: "Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid." [GOC:mengo_curators, PMID:19566715] +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0052810 +name: 1-phosphatidylinositol-5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+)." [PMID:12270933, PMID:9660759, RHEA:44680] +synonym: "1-phosphatidylinositol 5-kinase activity" EXACT [] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity" EXACT [] +xref: Reactome:R-HSA-1675810 "PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane" +xref: Reactome:R-HSA-1675866 "PI is phosphorylated to PI5P by PIKFYVE at the late endosome membrane" +xref: RHEA:44680 +is_a: GO:0052742 ! phosphatidylinositol kinase activity + +[Term] +id: GO:0052811 +name: 1-phosphatidylinositol-3-phosphate 4-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+)." [PMID:9211928, PMID:9367159, PMID:9660759, RHEA:63688] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity" EXACT [] +synonym: "phosphatidylinositol 3-phosphate 4-kinase activity" EXACT [] +xref: Reactome:R-HSA-1676145 "PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane" +xref: RHEA:63688 +is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity + +[Term] +id: GO:0052812 +name: phosphatidylinositol-3,4-bisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153] +synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity" RELATED [EC:2.7.1.153] +xref: EC:2.7.1.153 +xref: Reactome:R-HSA-1675773 "PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane" +is_a: GO:0052813 ! phosphatidylinositol bisphosphate kinase activity + +[Term] +id: GO:0052813 +name: phosphatidylinositol bisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate." [GOC:ai] +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0052814 +name: medium-chain-aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons." [EC:1.2.1.48] +synonym: "medium-chain aliphatic aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48] +synonym: "medium-chain fatty aldehyde dehydrogenase activity" RELATED [EC:1.2.1.48] +synonym: "medium-chain-aldehyde:NAD+ oxidoreductase activity" RELATED [EC:1.2.1.48] +xref: EC:1.2.1.- +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0052815 +name: medium-chain acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length." [EC:3.1.2.19] +synonym: "medium-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "medium-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "medium-chain hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "medium-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] +is_a: GO:0047617 ! acyl-CoA hydrolase activity + +[Term] +id: GO:0052816 +name: long-chain acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length." [EC:3.1.2.19] +synonym: "long-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "long-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "long-chain hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "long-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] +is_a: GO:0047617 ! acyl-CoA hydrolase activity + +[Term] +id: GO:0052817 +name: very long chain acyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18." [EC:3.1.2.19] +synonym: "very long-chain acyl coenzyme A hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "very long-chain acyl-thioester hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "very long-chain hydrolase activity" RELATED [EC:3.1.2.19] +synonym: "very long-chain-acyl-CoA hydrolase activity" RELATED [EC:3.1.2.19] +is_a: GO:0052816 ! long-chain acyl-CoA hydrolase activity + +[Term] +id: GO:0052818 +name: heteroglycan 3-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:RXN-7992] +synonym: "GDP mannose 3-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "heteropolysaccharide 3-alpha-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.48 +xref: KEGG_REACTION:R03769 +xref: MetaCyc:RXN-7992 +is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity + +[Term] +id: GO:0052819 +name: heteroglycan 2-alpha-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP." [EC:2.4.1.48, MetaCyc:2.4.1.48-RXN] +synonym: "GDP mannose 2-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity" RELATED [EC:2.4.1.48] +synonym: "heteropolysaccharide 2-alpha-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.48 +xref: KEGG_REACTION:R03768 +xref: MetaCyc:2.4.1.48-RXN +is_a: GO:0047264 ! heteroglycan alpha-mannosyltransferase activity + +[Term] +id: GO:0052820 +name: DNA-1,N6-ethenoadenine N-glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar." [PMID:21960007] +synonym: "1,N(6)-ethenoadenine N-glycosylase activity" EXACT [] +synonym: "1,N6-ethenoadenine glycosylase activity" EXACT [] +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0052821 +name: DNA-7-methyladenine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site." [GOC:jl, PMID:16468998] +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:0052822 +name: DNA-3-methylguanine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] +synonym: "3-methylguanine DNA glycosylase I" RELATED [EC:3.2.2.20] +synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] +synonym: "deoxyribonucleate 3-methylguanine glycosidase I" RELATED [EC:3.2.2.20] +synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] +xref: EC:3.2.2.21 +xref: MetaCyc:3.2.2.21-RXN +is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity + +[Term] +id: GO:0052823 +name: 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+." [RHEA:25046] +synonym: "(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14] +synonym: "2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r1622] +xref: EC:3.7.1.14 +xref: MetaCyc:RXN-12070 +xref: RHEA:25046 +xref: UM-BBD_reactionID:r1622 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0052825 +name: inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855219 "I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol" +is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity + +[Term] +id: GO:0052826 +name: inositol hexakisphosphate 2-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.62] +synonym: "1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity" RELATED [EC:3.1.3.62] +xref: EC:3.1.3.62 +xref: Reactome:R-HSA-1855225 "IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen" +is_a: GO:0004446 ! inositol-hexakisphosphate phosphatase activity + +[Term] +id: GO:0052827 +name: inositol pentakisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate." [GOC:bf] +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0052828 +name: inositol-3,4-bisphosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate." [GOC:mah] +xref: Reactome:R-HSA-1855202 "I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol" +xref: RHEA:43388 +is_a: GO:0016312 ! inositol bisphosphate phosphatase activity + +[Term] +id: GO:0052829 +name: inositol-1,3,4-trisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855232 "I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol" +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:0052830 +name: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855171 "I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol" +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:0052831 +name: inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate." [GOC:ai] +xref: Reactome:R-HSA-1855159 "I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol" +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:0052832 +name: inositol monophosphate 3-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] +xref: EC:3.1.3.25 +xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN +xref: Reactome:R-HSA-1855210 "I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol" +xref: RHEA:30739 +is_a: GO:0052834 ! inositol monophosphate phosphatase activity + +[Term] +id: GO:0052833 +name: inositol monophosphate 4-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] +synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] +synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD [] +synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [] +xref: EC:3.1.3.25 +xref: MetaCyc:RXN-10952 +xref: Reactome:R-HSA-1855211 "I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol" +xref: RHEA:30735 +is_a: GO:0052834 ! inositol monophosphate phosphatase activity + +[Term] +id: GO:0052834 +name: inositol monophosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] +synonym: "inositol phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] +synonym: "inositol-phosphate phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "L-myo-inositol-phosphate phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol monophosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25] +synonym: "myo-inositol-phosphatase activity" RELATED [EC:3.1.3.25] +synonym: "myo-inositol-phosphate phosphohydrolase activity" RELATED [EC:3.1.3.25] +xref: EC:3.1.3.25 +xref: MetaCyc:RXN-10949 +xref: RHEA:24056 +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0052835 +name: inositol-3,4,6-trisphosphate 1-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+)." [GOC:curators] +synonym: "1D-myo-inositol-trisphosphate 1-kinase activity" BROAD [] +synonym: "ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity" RELATED [] +synonym: "inositol 3,4,6-trisphosphate 1-kinase activity" EXACT [] +synonym: "inositol-trisphosphate 1-kinase activity" BROAD [] +synonym: "ins(3,4,6)P(3) 1-kinase activity" RELATED [] +synonym: "Ins(3,4,6)P3 1-kinase activity" RELATED [] +synonym: "IP3 1-kinase activity" BROAD [] +xref: Reactome:R-HSA-1855169 "I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol" +is_a: GO:0051766 ! inositol trisphosphate kinase activity + +[Term] +id: GO:0052836 +name: inositol 5-diphosphate pentakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate." [PMID:11502751, PMID:18355727] +xref: Reactome:R-HSA-1855158 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol" +xref: Reactome:R-HSA-1855224 "5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0052837 +name: thiazole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [GOC:curators] +synonym: "thiazole anabolism" EXACT [] +synonym: "thiazole biosynthesis" EXACT [] +synonym: "thiazole formation" EXACT [] +synonym: "thiazole synthesis" EXACT [] +is_a: GO:0018131 ! oxazole or thiazole biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0052838 ! thiazole metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0052838 +name: thiazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position." [GOC:curators] +synonym: "thiazole metabolism" EXACT [] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0046484 ! oxazole or thiazole metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0052839 +name: inositol diphosphate tetrakisphosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate." [PMID:10827188, PMID:11502751, PMID:18355727] +xref: Reactome:R-HSA-1855193 "1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol" +xref: Reactome:R-HSA-1855230 "5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus" +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0052840 +name: inositol diphosphate tetrakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate." [MetaCyc:RXN-10963, PMID:10827188, PMID:11502751] +xref: EC:3.6.1.52 +xref: MetaCyc:RXN-10963 +xref: Reactome:R-HSA-1855166 "PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol" +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0052841 +name: inositol bisdiphosphate tetrakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate." [MetaCyc:RXN-10965, MetaCyc:RXN-10975, MetaCyc:RXN-10976, PMID:10827188, PMID:11502751] +xref: Reactome:R-HSA-1855165 "(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol" +xref: Reactome:R-HSA-2023973 "(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol" +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0052842 +name: inositol diphosphate pentakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate." [MetaCyc:RXN-10964, MetaCyc:RXN-10977, MetaCyc:RXN-10978, PMID:10827188, PMID:11502751] +xref: EC:3.6.1.52 +xref: KEGG_REACTION:R05779 +xref: Reactome:R-HSA-1855198 "5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" +xref: Reactome:R-HSA-2023971 "1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol" +xref: RHEA:22384 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0052843 +name: inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10977, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10977 +is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity + +[Term] +id: GO:0052844 +name: inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10978, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10978 +is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity + +[Term] +id: GO:0052845 +name: inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+." [MetaCyc:RXN-10964, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10964 +is_a: GO:0052842 ! inositol diphosphate pentakisphosphate diphosphatase activity + +[Term] +id: GO:0052846 +name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10965, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10965 +is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity + +[Term] +id: GO:0052847 +name: inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10975, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10975 +is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity + +[Term] +id: GO:0052848 +name: inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+." [MetaCyc:RXN-10976, PMID:10827188, PMID:11502751] +xref: MetaCyc:RXN-10976 +is_a: GO:0052841 ! inositol bisdiphosphate tetrakisphosphate diphosphatase activity + +[Term] +id: GO:0052849 +name: NADPH-dependent curcumin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+." [MetaCyc:RXN0-6676] +xref: EC:1.3.1.n3 +xref: MetaCyc:RXN0-6676 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052850 +name: NADPH-dependent dihydrocurcumin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+." [MetaCyc:RXN0-6677] +synonym: "dihydrocurcumin reductase (NADPH) activity" EXACT [] +xref: MetaCyc:RXN0-6677 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052851 +name: ferric-chelate reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH." [RHEA:28795] +synonym: "ferric chelate reductase activity" BROAD [] +synonym: "ferric reductase, NADPH-dependent activity" EXACT [] +synonym: "iron chelate reductase activity" BROAD [] +xref: EC:1.16.1.9 +xref: KEGG_REACTION:R09541 +xref: MetaCyc:RXN0-6555 +xref: RHEA:28795 +is_a: GO:0000293 ! ferric-chelate reductase activity +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0052855 +name: ADP-dependent NAD(P)H-hydrate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate." [EC:4.2.1.93, PMID:21994945] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)" RELATED [EC:4.2.1.136] +synonym: "(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)" RELATED [EC:4.2.1.136] +synonym: "ADP-dependent H(4)NAD(P)OH dehydratase activity" EXACT [] +synonym: "ADP-dependent H4NAD(P)OH dehydratase activity" EXACT [] +synonym: "reduced nicotinamide adenine dinucleotide hydrate dehydratase activity" BROAD [EC:4.2.1.93] +xref: EC:4.2.1.136 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0052856 +name: NADHX epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-NADHX = (S)-NADHX." [PMID:21994945] +xref: EC:5.1.99.6 +xref: RHEA:32215 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0052857 +name: NADPHX epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX." [PMID:21994945] +xref: EC:5.1.99.6 +xref: Reactome:R-HSA-6806966 "APOA1BP dimer epimerises R-NAD(P)HX to S-NAD(P)HX" +xref: RHEA:32227 +is_a: GO:0016854 ! racemase and epimerase activity + +[Term] +id: GO:0052858 +name: peptidyl-lysine acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine." [GOC:tb] +synonym: "acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity" EXACT [] +synonym: "acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity" EXACT [] +synonym: "peptidyl-lysine N(6)-acetyltransferase activity" EXACT [] +synonym: "peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor" EXACT [] +synonym: "peptidyl-lysine N6-acetyltransferase activity" EXACT [] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0052859 +name: glucan endo-1,4-beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans." [EC:3.2.1.75] +synonym: "1,4-beta-D-glucan glucanohydrolase activity" EXACT [] +synonym: "beta-1,4-glucan 4-glucanohydrolase activity" EXACT [] +synonym: "beta-1,4-glucan hydrolase activity" EXACT [] +synonym: "beta-1,4-glucanase activity" EXACT [] +synonym: "beta-1->4-glucan hydrolase activity" EXACT [] +synonym: "endo-(1,4)-beta-D-glucanase activity" EXACT [] +synonym: "endo-(1->4)-beta-D-glucanase activity" EXACT [] +synonym: "endo-1,4-beta-D-glucanase activity" EXACT [] +synonym: "endo-1,4-beta-glucanase activity" EXACT [] +synonym: "endo-beta-1,4-glucanase activity" EXACT [] +xref: EC:3.2.1.- +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0052860 +name: 2'-deoxymugineic-acid 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2." [EC:1.14.11.25] +synonym: "2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.25] +xref: EC:1.14.11.25 +xref: KEGG_REACTION:R07187 +xref: MetaCyc:RXN-7983 +xref: RHEA:20065 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0052861 +name: glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] +synonym: "1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity" RELATED [EC:3.2.1.6] +synonym: "laminaranase activity" RELATED [EC:3.2.1.6] +synonym: "laminarinase activity" RELATED [EC:3.2.1.6] +xref: EC:3.2.1.6 +xref: MetaCyc:3.2.1.6-RXN +is_a: GO:0052736 ! beta-glucanase activity + +[Term] +id: GO:0052862 +name: glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group +namespace: molecular_function +def: "Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3." [EC:3.2.1.6] +synonym: "1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity" RELATED [EC:3.2.1.6] +synonym: "laminaranase activity" RELATED [EC:3.2.1.6] +synonym: "laminarinase activity" RELATED [EC:3.2.1.6] +xref: EC:3.2.1.6 +xref: MetaCyc:3.2.1.6-RXN +is_a: GO:0052736 ! beta-glucanase activity + +[Term] +id: GO:0052863 +name: 1-deoxy-D-xylulose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolic process" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate metabolism" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate metabolism" EXACT [] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0052864 +name: 1-deoxy-D-xylulose 5-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate breakdown" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolic process" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate catabolism" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate degradation" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate breakdown" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate catabolism" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate degradation" EXACT [] +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0052865 +name: 1-deoxy-D-xylulose 5-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis." [GOC:curators] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate anabolism" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthesis" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate biosynthetic process" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate formation" EXACT [] +synonym: "(2R,3S)-2,3-dihydroxy-4-oxopentyl dihydrogen phosphate synthesis" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate anabolism" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate biosynthesis" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate formation" EXACT [] +synonym: "1-deoxy-D-xylulose 5-phosphate synthesis" EXACT [] +xref: UniPathway:UPA00064 +is_a: GO:0052863 ! 1-deoxy-D-xylulose 5-phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:0052866 +name: phosphatidylinositol phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate." [GOC:ai] +synonym: "phosphoinositide phosphatase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0052867 +name: phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate." [GOC:curators] +synonym: "phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity" BROAD [] +synonym: "phosphatidylinositol 1,4,5-trisphosphate phosphatase activity" BROAD [] +synonym: "phosphatidylinositol-trisphosphatase activity" BROAD [] +synonym: "PtdIns(1,4,5)P(3) phosphatase activity" BROAD [] +synonym: "PtdIns(1,4,5)P3 phosphatase activity" BROAD [] +synonym: "triphosphoinositide phosphatase activity" BROAD [] +synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [] +is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity +is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity + +[Term] +id: GO:0052868 +name: protein-lysine lysyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine." [PMID:20729861] +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0052869 +name: arachidonic acid omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid." [KEGG_REACTION:R07041] +synonym: "arachidonic acid hydroxylase activity" BROAD [] +synonym: "arachidonic acid:oxygen 1-oxidoreductase activity" EXACT systematic_synonym [] +xref: EC:1.14.15.3 +xref: KEGG_REACTION:R07041 +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052870 +name: tocopherol omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] +synonym: "tocopherol 13-hydroxylase activity" EXACT systematic_synonym [] +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052871 +name: alpha-tocopherol omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." [MetaCyc:RXN-11003] +synonym: "alpha-tocopherol 13-hydroxylase activity" EXACT [] +xref: MetaCyc:RXN-11003 +is_a: GO:0052870 ! tocopherol omega-hydroxylase activity + +[Term] +id: GO:0052872 +name: tocotrienol omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O ." [MetaCyc:RXN-11003] +synonym: "tocotrienol 13-hydroxylase activity" EXACT [] +xref: EC:1.14.13.- +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052873 +name: FMN reductase (NADPH) activity +namespace: molecular_function +def: "Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+." [RHEA:21624] +synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "FMNH2:NADP+ oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH dehydrogenase (FMN) activity" EXACT [] +synonym: "NADPH(2) dehydrogenase (FMN) activity" RELATED [EC:1.5.1.29] +synonym: "NADPH(2):FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH-dependent FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH-FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH2 dehydrogenase (FMN)" RELATED [EC:1.5.1.3] +synonym: "NADPH2:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH:flavin oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADPH:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "SsuE" RELATED [EC:1.5.1.29] +xref: EC:1.5.1.38 +xref: EC:1.5.1.39 +xref: KEGG_REACTION:R05706 +xref: Reactome:R-HSA-1222399 "Iron is reduced and separates from mycobactin" +xref: RHEA:21624 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052874 +name: FMN reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+." [RHEA:21620] +synonym: "flavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "flavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] +synonym: "FMNH2:NAD+ oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH dehydrogenase (FMN) activity" EXACT [] +synonym: "NADH(2) dehydrogenase (FMN) activity" RELATED [EC:1.5.1.29] +synonym: "NADH(2):FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH-dependent FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH-FMN reductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH2 dehydrogenase (FMN)" RELATED [EC:1.5.1.3] +synonym: "NADH2:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH:flavin oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "NADH:FMN oxidoreductase activity" RELATED [EC:1.5.1.29] +synonym: "SsuE" RELATED [EC:1.5.1.29] +xref: EC:1.5.1.39 +xref: KEGG_REACTION:R05705 +xref: RHEA:21620 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052875 +name: riboflavin reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+." [RHEA:31455] +synonym: "flavin mononucleotide reductase activity" RELATED [EC:1.5.1.41] +synonym: "flavine mononucleotide reductase activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H-dependent FMN reductase activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H-FMN reductase activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H2 dehydrogenase (FMN) activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H2:FMN oxidoreductase activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H:FMN oxidoreductase activity" RELATED [EC:1.5.1.41] +synonym: "NAD(P)H:riboflavin oxidoreductase activity" RELATED [EC:1.5.1.41] +synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.41] +synonym: "riboflavin mononucleotide reductase activity" RELATED [EC:1.5.1.41] +synonym: "riboflavine mononucleotide reductase activity" RELATED [EC:1.5.1.41] +xref: EC:1.5.1.41 +xref: KEGG_REACTION:R09750 +xref: MetaCyc:RXN-12445 +xref: RHEA:31455 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0052876 +name: methylamine dehydrogenase (amicyanin) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]." [RHEA:30207] +synonym: "amine dehydrogenase" BROAD [EC:1.4.9.1] +synonym: "MADH activity" BROAD [EC:1.4.9.1] +synonym: "methylamine dehydrogenase activity" EXACT [EC:1.4.9.1] +synonym: "methylamine:amicyanin oxidoreductase (deaminating) activity" EXACT systematic_synonym [] +synonym: "primary-amine dehydrogenase" BROAD [EC:1.4.9.1] +xref: EC:1.4.9.1 +xref: KEGG_REACTION:R00606 +xref: RHEA:30207 +xref: UM-BBD_reactionID:r0075 +is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor + +[Term] +id: GO:0052877 +name: oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor." [GOC:ai] +xref: EC:1.4.9.- +is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors + +[Term] +id: GO:0052878 +name: linoleate 8R-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate." [RHEA:25395] +synonym: "5,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] +synonym: "5,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] +synonym: "7,8-LDS (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] +synonym: "7,8-linoleate diol synthase (bifunctional enzyme) activity" RELATED [EC:1.13.11.60] +synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44] +xref: EC:1.13.11.60 +xref: KEGG_REACTION:R07061 +xref: MetaCyc:1.13.11.44-RXN +xref: RHEA:25395 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0052879 +name: 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate." [RHEA:25399] +synonym: "(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity" RELATED [EC:5.4.4.6] +synonym: "8-hydroperoxide isomerase activity" BROAD [EC:5.4.4.6] +synonym: "linoleate diol synthase activity" RELATED [EC:1.13.11.44] +xref: EC:5.4.4.6 +xref: KEGG_REACTION:R07062 +xref: MetaCyc:1.13.11.44-RXN +xref: RHEA:25399 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0052880 +name: oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl] +xref: EC:1.10.9.- +is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors + +[Term] +id: GO:0052881 +name: 4-hydroxyphenylacetate 3-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O." [RHEA:30595] +synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.14.9] +synonym: "4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT systematic_synonym [] +synonym: "4-hydroxyphenylacetic acid-3-hydroxylase activity" BROAD [EC:1.14.14.9] +synonym: "p-hydroxyphenylacetate 3-hydroxylase (FAD) activity" RELATED [EC:1.14.14.9] +synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.14.9] +synonym: "p-hydroxyphenylacetate hydroxylase (FAD) activity" RELATED [EC:1.14.14.9] +synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.14.9] +xref: EC:1.14.14.9 +xref: MetaCyc:RXN-8505 +xref: RHEA:30595 +xref: UM-BBD_reactionID:r0301 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0052882 +name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein." [GOC:jl] +xref: EC:1.20.9.- +is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors + +[Term] +id: GO:0052883 +name: tyrosine ammonia-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate." [RHEA:24906] +synonym: "L-tyrosine ammonia-lyase activity" RELATED [EC:4.3.1.23] +synonym: "TAL activity" BROAD [EC:4.3.1.23] +synonym: "tyrase activity" BROAD [EC:4.3.1.23] +xref: EC:4.3.1.23 +xref: EC:4.3.1.25 +xref: RHEA:24906 +is_a: GO:0016841 ! ammonia-lyase activity + +[Term] +id: GO:0052884 +name: all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate." [RHEA:31775] +synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64] +synonym: "all-trans-retinyl-palmitate hydrolase activity" BROAD [EC:3.1.1.64] +synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64] +synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64] +xref: EC:3.1.1.64 +xref: Reactome:R-HSA-2453833 "RPE65 isomero-hydrolyses atREs to 11cROL" +xref: RHEA:31775 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052885 +name: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid." [RHEA:31771] +synonym: "all-trans-retinol isomerase:hydrolase activity" BROAD [EC:3.1.1.64] +synonym: "all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity" RELATED [EC:3.1.1.64] +synonym: "all-trans-retinylester 11-cis isomerohydrolase activity" RELATED [EC:3.1.1.64] +synonym: "retinoid isomerohydrolase activity" BROAD [EC:3.1.1.64] +synonym: "retinol isomerase activity" BROAD [EC:3.1.1.64] +xref: EC:3.1.1.64 +xref: KEGG_REACTION:R08388 +xref: MetaCyc:RXN-12550 +xref: RHEA:31771 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0052886 +name: 9,9'-dicis-carotene:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol." [RHEA:30959] +synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] +synonym: "ZDS activity" BROAD [EC:1.3.5.6] +synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] +xref: EC:1.3.5.6 +xref: KEGG_REACTION:R09656 +xref: MetaCyc:RXN-11356 +xref: RHEA:30959 +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0052887 +name: 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol." [EC:1.3.5.6] +synonym: "9,9'-di-cis-zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] +synonym: "ZDS activity" BROAD [EC:1.3.5.6] +synonym: "zeta-carotene desaturase activity" BROAD [EC:1.3.5.6] +xref: EC:1.3.5.6 +xref: KEGG_REACTION:R09658 +xref: MetaCyc:RXN-11357 +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0052888 +name: obsolete dihydroorotate oxidase (fumarate) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [GOC:curators] +comment: EC has determined that this reaction in fact does not exist and have withdrawn EC:1.3.3.1. Note: If fumarate is not shown to be involved, you may want to consider GO:0004152, dihydroorotate dehydrogenase activity (parent term); if the reaction involves fumarate, then use GO:0052888 dihydroorotate oxidase (fumarate) activity. Details at http://sourceforge.net/p/geneontology/ontology-requests/10770/, RHEA:30059 and EC:1.3.98 removed so as not to conflict with remapping +synonym: "DHOD activity" BROAD [] +synonym: "DHOdase activity" BROAD [] +synonym: "DHodehase activity" BROAD [] +synonym: "dihydoorotic acid dehydrogenase activity" BROAD [] +synonym: "dihydroorotate dehydrogenase activity" BROAD [] +synonym: "dihydroorotate oxidase (fumarate) activity" EXACT [] +synonym: "dihydroorotate oxidase activity" BROAD [] +xref: EC:1.3.98.1 +xref: KEGG_REACTION:R01867 +xref: MetaCyc:RXN-9929 +is_obsolete: true + +[Term] +id: GO:0052889 +name: 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene +namespace: biological_process +def: "The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene." [EC:1.3.5.6, KEGG_REACTION:R07511] +synonym: "7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene" EXACT [] +synonym: "9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene" EXACT [] +xref: KEGG_REACTION:R07511 +xref: MetaCyc:RXN-12242 +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:0052890 +name: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin." [GOC:jl] +xref: EC:1.3.8.- +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0052891 +name: aliphatic (S)-hydroxynitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide." [EC:4.1.2.47] +synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47] +synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47] +xref: EC:4.1.2.47 +xref: MetaCyc:RXN-11731 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0052892 +name: aromatic (S)-hydroxynitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide." [EC:4.1.2.47, KEGG_REACTION:R09359] +synonym: "(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity" BROAD [EC:4.1.2.47] +synonym: "(S)-cyanohydrin producing hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-oxynitrilase activity" BROAD [EC:4.1.2.47] +synonym: "(S)-selective hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "hydroxynitrile lyase activity" BROAD [EC:4.1.2.47] +synonym: "oxynitrilase activity" BROAD [EC:4.1.2.47] +xref: EC:4.1.2.47 +xref: KEGG_REACTION:R09359 +xref: MetaCyc:RXN-11732 +xref: RHEA:54660 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0052893 +name: N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide." [MetaCyc:RXN-10465] +synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] +xref: EC:1.5.3.14 +xref: MetaCyc:RXN-10465 +xref: RHEA:25996 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052894 +name: norspermine:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:RXN-10464] +synonym: "norspermine oxidase activity" BROAD [EC:1.5.3.16] +xref: EC:1.5.3.16 +xref: MetaCyc:RXN-10464 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052895 +name: N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide." [MetaCyc:POLYAMINE-OXIDASE-RXN] +synonym: "N1-acetylspermine oxidase activity" BROAD [EC:1.5.3.16] +xref: EC:1.5.3.16 +xref: MetaCyc:POLYAMINE-OXIDASE-RXN +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052896 +name: spermidine oxidase (propane-1,3-diamine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2)." [RHEA:25820] +synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] +synonym: "spermidine:(acceptor) oxidoreductase activity" BROAD [EC:1.5.3.14] +xref: EC:1.5.3.14 +xref: KEGG_REACTION:R01914 +xref: MetaCyc:RXN-10747 +xref: RHEA:25820 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052897 +name: N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25972] +synonym: "N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.15] +xref: EC:1.5.3.15 +xref: KEGG_REACTION:R09075 +xref: MetaCyc:RXN-10463 +xref: RHEA:25972 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052898 +name: N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2)." [RHEA:25864] +xref: EC:1.5.3.15 +xref: RHEA:25864 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052899 +name: N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine." [RHEA:25868] +synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] +synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] +xref: EC:1.5.3.13 +xref: MetaCyc:RXN-10460 +xref: RHEA:25868 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052900 +name: spermine oxidase (propane-1,3-diamine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal." [RHEA:25824] +synonym: "polyamine oxidase (propane-1,3-diamine-forming) activity" BROAD [EC:1.5.3.14] +xref: EC:1.5.3.14 +xref: MetaCyc:RXN-6421 +xref: RHEA:25824 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052901 +name: spermine:oxygen oxidoreductase (spermidine-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine." [RHEA:25804] +synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] +synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] +synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] +synonym: "spermine oxidase activity" BROAD [EC:1.5.3.16] +xref: EC:1.5.3.13 +xref: EC:1.5.3.16 +xref: EC:1.5.3.17 +xref: KEGG_REACTION:R09076 +xref: MetaCyc:1.5.3.17-RXN +xref: MetaCyc:RXN-9015 +xref: Reactome:R-HSA-141341 "SMOX-3 oxidises SPN to SPM" +xref: RHEA:25804 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052902 +name: spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine." [RHEA:25808] +synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] +synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] +synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] +xref: EC:1.5.3.13 +xref: EC:1.5.3.17 +xref: KEGG_REACTION:R09077 +xref: MetaCyc:RXN-10461 +xref: MetaCyc:RXN-12089 +xref: RHEA:25808 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052903 +name: N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine." [RHEA:25800] +synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] +synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] +synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] +xref: EC:1.5.3.13 +xref: EC:1.5.3.17 +xref: KEGG_REACTION:R03899 +xref: MetaCyc:RXN-12090 +xref: MetaCyc:RXN-9940 +xref: RHEA:25800 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052904 +name: N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine." [RHEA:25812] +synonym: "N(1)-acetylpolyamine oxidase activity" BROAD [EC:1.5.3.13] +synonym: "non-specific polyamine oxidase activity" BROAD [EC:1.5.3.17] +synonym: "polyamine oxidase activity" BROAD [EC:1.5.3.13, EC:1.5.3.17] +xref: EC:1.5.3.13 +xref: EC:1.5.3.17 +xref: KEGG_REACTION:R09074 +xref: MetaCyc:RXN-12091 +xref: MetaCyc:RXN-9942 +xref: Reactome:R-HSA-141348 "PAO:FAD oxidises NASPM to PTCN" +xref: Reactome:R-HSA-141351 "PAOX:FAD oxidises NASPN to SPM" +xref: RHEA:25812 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0052905 +name: tRNA (guanine(9)-N(1))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.221] +synonym: "tRNA (guanine-N(1)-)-methyltransferase activity" RELATED [EC:2.1.1.221] +synonym: "tRNA m(1)G(9) Mtase activity" RELATED [EC:2.1.1.221] +synonym: "tRNA m(1)G(9)-methyltransferase activity" RELATED [EC:2.1.1.221] +synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" RELATED [EC:2.1.1.221] +synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" RELATED [EC:2.1.1.221] +xref: EC:2.1.1.221 +xref: MetaCyc:RXN-12459 +xref: RHEA:43156 +is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity + +[Term] +id: GO:0052906 +name: tRNA (guanine(37)-N(1))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.228] +synonym: "transfer RNA (m(1)G(37)) methyltransferase activity" RELATED [EC:2.1.1.228] +synonym: "tRNA (m(1)G(37)) methyltransferase activity" RELATED [EC:2.1.1.228] +synonym: "tRNA-(N(1)G37) methyltransferase activity" RELATED [EC:2.1.1.228] +xref: EC:2.1.1.228 +xref: MetaCyc:RXN-12458 +xref: RHEA:36899 +is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity + +[Term] +id: GO:0052907 +name: 23S rRNA (adenine(1618)-N(6))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA." [EC:2.1.1.181] +synonym: "M(6)A(1618) activity" BROAD [EC:2.1.1.181] +synonym: "rRNA large subunit methyltransferase F activity" RELATED [EC:2.1.1.181] +xref: EC:2.1.1.181 +xref: KEGG_REACTION:R07232 +xref: MetaCyc:RXN-11596 +xref: RHEA:16497 +is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity + +[Term] +id: GO:0052908 +name: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA." [RHEA:19609] +synonym: "S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity" RELATED [EC:2.1.1.182] +xref: EC:2.1.1.182 +xref: MetaCyc:RXN-11633 +xref: RHEA:19609 +is_a: GO:0000179 ! rRNA (adenine-N6,N6-)-dimethyltransferase activity + +[Term] +id: GO:0052909 +name: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA." [RHEA:42780] +synonym: "M(6)(2)A dimethylase activity" BROAD [EC:2.1.1.183] +xref: EC:2.1.1.183 +xref: MetaCyc:RXN-11634 +xref: RHEA:42780 +is_a: GO:0000179 ! rRNA (adenine-N6,N6-)-dimethyltransferase activity + +[Term] +id: GO:0052910 +name: 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA." [EC:2.1.1.184] +synonym: "ermC 23S rRNA methyltransferase activity" RELATED [EC:2.1.1.184] +synonym: "rRNA methyltransferase ermC' activity" RELATED [EC:2.1.1.184] +synonym: "rRNA:m(6)A methyltransferase ermC' activity" RELATED [EC:2.1.1.184] +xref: EC:2.1.1.184 +xref: MetaCyc:RXN-11597 +xref: RHEA:42784 +is_a: GO:0008988 ! rRNA (adenine-N6-)-methyltransferase activity + +[Term] +id: GO:0052911 +name: 23S rRNA (guanine(745)-N(1))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.187] +synonym: "23S rRNA m(1)G(745) methyltransferase activity" RELATED [EC:2.1.1.187] +synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" BROAD [EC:2.1.1.187] +synonym: "ribosomal RNA(m(1)G)-methylase activity" BROAD [EC:2.1.1.187] +synonym: "rlmA(I) methyltransferase activity" BROAD [EC:2.1.1.187] +synonym: "rRNA(m(1)G)methylase activity" BROAD [EC:2.1.1.187] +synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" BROAD [EC:2.1.1.187] +xref: EC:2.1.1.187 +xref: KEGG_REACTION:R07233 +xref: MetaCyc:RXN-11573 +xref: RHEA:42900 +is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity + +[Term] +id: GO:0052912 +name: 23S rRNA (guanine(748)-N(1))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.188] +synonym: "23S rRNA m(1)G(748) methyltransferase activity" BROAD [EC:2.1.1.188] +xref: EC:2.1.1.188 +xref: KEGG_REACTION:R07233 +xref: MetaCyc:RXN-11599 +xref: RHEA:42904 +is_a: GO:0008989 ! rRNA (guanine-N1-)-methyltransferase activity + +[Term] +id: GO:0052913 +name: 16S rRNA (guanine(966)-N(2))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.171] +xref: EC:2.1.1.171 +xref: KEGG_REACTION:R07234 +xref: MetaCyc:RXN0-6515 +xref: RHEA:23548 +is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity + +[Term] +id: GO:0052914 +name: 16S rRNA (guanine(1207)-N(2))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.172] +synonym: "M(2)G1207 methyltransferase activity" RELATED [EC:2.1.1.172] +xref: EC:2.1.1.172 +xref: KEGG_REACTION:R07234 +xref: MetaCyc:RXN-11576 +xref: RHEA:42736 +is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity + +[Term] +id: GO:0052915 +name: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.173] +xref: EC:2.1.1.173 +xref: KEGG_REACTION:R07234 +xref: MetaCyc:RXN-11574 +xref: RHEA:42740 +is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity + +[Term] +id: GO:0052916 +name: 23S rRNA (guanine(1835)-N(2))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.174] +xref: EC:2.1.1.174 +xref: KEGG_REACTION:R07234 +xref: MetaCyc:RXN-11635 +xref: RHEA:42744 +is_a: GO:0008990 ! rRNA (guanine-N2-)-methyltransferase activity + +[Term] +id: GO:0052917 +name: dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase +namespace: molecular_function +alt_id: GO:0052824 +def: "Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol." [PMID:10336995, RHEA:29535] +synonym: "dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity" EXACT [EC:2.4.1.260] +synonym: "dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" EXACT [EC:2.4.1.260] +synonym: "dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity" EXACT [] +xref: EC:2.4.1.260 +xref: KEGG_REACTION:R06260 +xref: MetaCyc:RXN-5468 +xref: RHEA:29535 +is_a: GO:0000009 ! alpha-1,6-mannosyltransferase activity + +[Term] +id: GO:0052918 +name: dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.261, RHEA:29539] +xref: EC:2.4.1.261 +xref: KEGG_REACTION:R06261 +xref: MetaCyc:RXN-5469 +xref: RHEA:29539 +is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity + +[Term] +id: GO:0052919 +name: aliphatic (R)-hydroxynitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide." [EC:4.1.2.46] +synonym: "(R)-HNL activity" BROAD [EC:4.1.2.46] +synonym: "(R)-hydroxynitrile lyase activity" BROAD [EC:4.1.2.46] +synonym: "(R)-oxynitrilase activity" BROAD [EC:4.1.2.46] +xref: EC:4.1.2.46 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0052920 +name: (2R)-2-hydroxy-2-methylbutanenitrile lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide." [EC:4.1.2.46] +xref: EC:4.1.2.46 +xref: KEGG_REACTION:R09358 +xref: MetaCyc:RXN-11733 +xref: RHEA:28170 +is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity + +[Term] +id: GO:0052921 +name: acetone-cyanohydrin acetone-lyase (cyanide-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone." [KEGG_REACTION:R01553, MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN] +xref: EC:4.1.2.46 +xref: KEGG_REACTION:R01553 +xref: MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN +xref: RHEA:11932 +is_a: GO:0052919 ! aliphatic (R)-hydroxynitrile lyase activity + +[Term] +id: GO:0052922 +name: hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate." [RHEA:27555] +synonym: "(all-E) hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82] +synonym: "(all-trans)-hexaprenyl-diphosphate synthase activity" BROAD [EC:2.5.1.82] +synonym: "hexaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.82] +synonym: "hexaprenyl pyrophosphate synthetase activity" BROAD [EC:2.5.1.82] +xref: EC:2.5.1.82 +xref: KEGG_REACTION:R09246 +xref: MetaCyc:RXN-11485 +xref: RHEA:27555 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0052923 +name: all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate." [RHEA:27563] +synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.84] +synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.84] +synonym: "solanesyl-diphosphate synthase activity" BROAD [EC:2.5.1.84] +synonym: "solPP synthase activity" BROAD [EC:2.5.1.84] +synonym: "SPP synthase activity" BROAD [EC:2.5.1.84] +synonym: "SPP-synthase activity" BROAD [EC:2.5.1.84] +xref: EC:2.5.1.84 +xref: KEGG_REACTION:R09250 +xref: MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN +xref: RHEA:27563 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0052924 +name: all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity +namespace: molecular_function +def: "Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate." [RHEA:27594] +synonym: "nonaprenyl diphosphate synthase activity" BROAD [EC:2.5.1.85] +synonym: "solanesyl diphosphate synthase activity" BROAD [EC:2.5.1.85] +synonym: "solanesyl diphosphate synthetase activity" BROAD [EC:2.5.1.85] +xref: EC:2.5.1.85 +xref: KEGG_REACTION:R09251 +xref: MetaCyc:RXN-11486 +xref: RHEA:27594 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0052925 +name: dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [RHEA:29527] +synonym: "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity" RELATED [EC:2.4.1.258] +synonym: "man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity" RELATED [EC:2.4.1.258] +xref: EC:2.4.1.258 +xref: KEGG_REACTION:R06258 +xref: MetaCyc:RXN-5466 +xref: RHEA:29527 +is_a: GO:0000033 ! alpha-1,3-mannosyltransferase activity + +[Term] +id: GO:0052926 +name: dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate." [EC:2.4.1.259, RHEA:29531] +synonym: "dolichylphosphomannose-dependent ALG9 mannosyltransferase activity" RELATED [EC:2.4.1.259] +xref: EC:2.4.1.259 +xref: KEGG_REACTION:R06259 +xref: MetaCyc:RXN-5467 +xref: RHEA:29531 +is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity + +[Term] +id: GO:0052927 +name: CTP:tRNA cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate." [KEGG_REACTION:R09383] +xref: EC:2.7.7.72 +xref: KEGG_REACTION:R09383 +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0052928 +name: CTP:3'-cytidine-tRNA cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate." [KEGG_REACTION:R09384] +xref: EC:2.7.7.72 +xref: KEGG_REACTION:R09384 +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0052929 +name: ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate." [RHEA:60012] +synonym: "ATP:3'-CC-tRNA adenylyltransferase activity" EXACT [] +synonym: "ATP:tRNA adenylyltransferase activity" BROAD [] +xref: EC:2.7.7.72 +xref: KEGG_REACTION:R09386 +xref: RHEA:60012 +is_a: GO:0004810 ! tRNA adenylyltransferase activity + +[Term] +id: GO:0052933 +name: alcohol dehydrogenase (cytochrome c(L)) activity +namespace: molecular_function +alt_id: GO:0052930 +alt_id: GO:0052931 +alt_id: GO:0052932 +def: "Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+." [RHEA:51004] +synonym: "2-chloroethanol cytochrome-c oxidoreductase activity" NARROW [] +synonym: "alcohol:cytochrome c(L) oxidoreductase activity" EXACT [] +synonym: "ethanol cytochrome-c oxidoreductase activity" NARROW [] +synonym: "methanol dehydrogenase activity" NARROW [EC:1.1.2.7] +synonym: "methanol ferricytochrome-c oxidoreductase activity" NARROW [] +xref: EC:1.1.2.7 +xref: KEGG_REACTION:R01146 +xref: KEGG_REACTION:R09127 +xref: KEGG_REACTION:R09128 +xref: MetaCyc:RXN-11332 +xref: MetaCyc:RXN-2861 +xref: RHEA:51004 +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0052934 +name: alcohol dehydrogenase (cytochrome c) activity +namespace: molecular_function +alt_id: GO:0018468 +alt_id: GO:0052935 +alt_id: GO:0052936 +def: "Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+." [RHEA:51020] +synonym: "2-chloroethanol:cytochrome c oxidoreductase activity" NARROW [] +synonym: "alcohol dehydrogenase (acceptor) activity" BROAD [] +synonym: "alcohol:(acceptor) oxidoreductase activity" RELATED [] +synonym: "alcohol:acceptor oxidoreductase activity" RELATED [] +synonym: "alcohol:cytochrome c oxidoreductase activity" EXACT [] +synonym: "ethanol:cytochrome c oxidoreductase activity" NARROW [] +synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] +synonym: "quinoprotein alcohol dehydrogenase activity" RELATED [] +xref: EC:1.1.2.8 +xref: KEGG_REACTION:R05198 +xref: KEGG_REACTION:R05285 +xref: MetaCyc:RXN-11333 +xref: RHEA:51020 +xref: UM-BBD_enzymeID:e0004 +is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor + +[Term] +id: GO:0055001 +name: muscle cell development +namespace: biological_process +alt_id: GO:0048747 +def: "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate." [CL:0000187, GOC:devbiol] +synonym: "muscle fiber development" EXACT [] +synonym: "muscle fibre development" EXACT [] +synonym: "myofiber development" EXACT [] +synonym: "myofibre development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0042692 ! muscle cell differentiation + +[Term] +id: GO:0055002 +name: striated muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:devbiol] +is_a: GO:0055001 ! muscle cell development +relationship: part_of GO:0051146 ! striated muscle cell differentiation + +[Term] +id: GO:0055003 +name: cardiac myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "cardiac myofibril development" EXACT [] +synonym: "cardiac myofibril morphogenesis" EXACT [] +synonym: "heart myofibril assembly" RELATED [] +is_a: GO:0030239 ! myofibril assembly +relationship: part_of GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0055004 +name: atrial cardiac myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "atrial cardiac myofibril development" EXACT [GOC:dph] +synonym: "atrial heart myofibril development" EXACT [] +is_a: GO:0055003 ! cardiac myofibril assembly +relationship: part_of GO:0055014 ! atrial cardiac muscle cell development + +[Term] +id: GO:0055005 +name: ventricular cardiac myofibril assembly +namespace: biological_process +def: "The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:devbiol] +synonym: "ventricular cardiac myofibril development" RELATED [] +synonym: "ventricular heart myofibril development" EXACT [] +is_a: GO:0055003 ! cardiac myofibril assembly +relationship: part_of GO:0055015 ! ventricular cardiac muscle cell development + +[Term] +id: GO:0055006 +name: cardiac cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." [GOC:devbiol] +synonym: "cardiocyte development" EXACT [GOC:dph] +synonym: "heart cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:0055007 +name: cardiac muscle cell differentiation +namespace: biological_process +def: "The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:devbiol, GOC:mtg_heart] +synonym: "cardiomyocyte differentiation" EXACT [] +synonym: "heart muscle cell differentiation" RELATED [] +is_a: GO:0035051 ! cardiocyte differentiation +is_a: GO:0051146 ! striated muscle cell differentiation +relationship: part_of GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0055008 +name: cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cardiac muscle tissue are generated and organized." [GOC:devbiol] +synonym: "heart muscle morphogenesis" EXACT [] +synonym: "myocardium morphogenesis" BROAD [GOC:mtg_heart] +is_a: GO:0060415 ! muscle tissue morphogenesis +relationship: part_of GO:0003007 ! heart morphogenesis +relationship: part_of GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0055009 +name: atrial cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of cardiac atrium muscle is generated and organized." [GOC:devbiol] +synonym: "atrial heart muscle morphogenesis" EXACT [] +synonym: "atrial myocardium morphogenesis" EXACT [GOC:mtg_heart] +synonym: "cardiac atrium muscle morphogenesis" EXACT [] +is_a: GO:0055008 ! cardiac muscle tissue morphogenesis +relationship: part_of GO:0003209 ! cardiac atrium morphogenesis +relationship: part_of GO:0003228 ! atrial cardiac muscle tissue development + +[Term] +id: GO:0055010 +name: ventricular cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cardiac ventricle muscle is generated and organized." [GOC:devbiol] +synonym: "cardiac ventricle muscle morphogenesis" EXACT [] +synonym: "ventricular heart muscle morphogenesis" EXACT [] +is_a: GO:0055008 ! cardiac muscle tissue morphogenesis +relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis +relationship: part_of GO:0003229 ! ventricular cardiac muscle tissue development + +[Term] +id: GO:0055011 +name: atrial cardiac muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol, GOC:mtg_heart] +synonym: "atrial cardiomyocyte differentiation" EXACT [] +synonym: "atrial heart muscle cell differentiation" EXACT [] +is_a: GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0055012 +name: ventricular cardiac muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_heart] +synonym: "ventricular cardiomyocyte differentiation" EXACT [] +synonym: "ventricular heart muscle cell differentiation" EXACT [] +is_a: GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0055013 +name: cardiac muscle cell development +namespace: biological_process +alt_id: GO:0048739 +def: "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state." [GOC:devbiol, GOC:mtg_heart] +synonym: "cardiac muscle fiber development" EXACT [] +synonym: "cardiac muscle fibre development" EXACT [] +synonym: "cardiomyocyte cell development" EXACT [GOC:mtg_muscle] +synonym: "heart muscle cell development" EXACT [] +synonym: "heart muscle fiber development" RELATED [] +is_a: GO:0055001 ! muscle cell development +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0055014 +name: atrial cardiac muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ." [GOC:devbiol] +synonym: "atrial cardiomyocyte development" EXACT [] +synonym: "atrial heart muscle development" EXACT [] +is_a: GO:0055013 ! cardiac muscle cell development +relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation + +[Term] +id: GO:0055015 +name: ventricular cardiac muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ." [GOC:devbiol, GOC:mtg_muscle] +synonym: "ventricular cardiomyocyte development" EXACT [] +synonym: "ventricular heart muscle cell development" EXACT [] +is_a: GO:0055013 ! cardiac muscle cell development +relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation + +[Term] +id: GO:0055016 +name: hypochord development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta." [GOC:devbiol, GOC:lb] +synonym: "subnotochordal rod development" EXACT [] +is_a: GO:0009888 ! tissue development +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:0055017 +name: cardiac muscle tissue growth +namespace: biological_process +def: "The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:devbiol] +synonym: "heart muscle growth" EXACT [] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048738 ! cardiac muscle tissue development +relationship: part_of GO:0060419 ! heart growth + +[Term] +id: GO:0055018 +name: regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "regulation of cardiac muscle fibre development" EXACT [] +synonym: "regulation of heart muscle fiber development" EXACT [] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation +relationship: regulates GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0055019 +name: negative regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "down regulation of cardiac muscle fiber development" EXACT [] +synonym: "down-regulation of cardiac muscle fiber development" EXACT [] +synonym: "downregulation of cardiac muscle fiber development" EXACT [] +synonym: "inhibition of cardiac muscle fiber development" NARROW [] +synonym: "negative regulation of cardiac muscle fibre development" EXACT [] +synonym: "negative regulation of heart muscle fiber development" RELATED [] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation +is_a: GO:0055018 ! regulation of cardiac muscle fiber development +relationship: negatively_regulates GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0055020 +name: positive regulation of cardiac muscle fiber development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development." [GOC:vk] +synonym: "activation of cardiac muscle fiber development" NARROW [] +synonym: "positive regulation of cardiac muscle fibre development" EXACT [] +synonym: "positive regulation of heart muscle fiber development" EXACT [] +synonym: "stimulation of cardiac muscle fiber development" NARROW [] +synonym: "up regulation of cardiac muscle fiber development" EXACT [] +synonym: "up-regulation of cardiac muscle fiber development" EXACT [] +synonym: "upregulation of cardiac muscle fiber development" EXACT [] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0055018 ! regulation of cardiac muscle fiber development +is_a: GO:2000727 ! positive regulation of cardiac muscle cell differentiation +relationship: positively_regulates GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0055021 +name: regulation of cardiac muscle tissue growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +is_a: GO:0060420 ! regulation of heart growth +relationship: regulates GO:0055017 ! cardiac muscle tissue growth + +[Term] +id: GO:0055022 +name: negative regulation of cardiac muscle tissue growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +synonym: "down regulation of cardiac muscle growth" EXACT [] +synonym: "down-regulation of cardiac muscle growth" EXACT [] +synonym: "downregulation of cardiac muscle growth" EXACT [] +synonym: "inhibition of cardiac muscle growth" NARROW [] +synonym: "negative regulation of heart muscle growth" RELATED [] +is_a: GO:0055021 ! regulation of cardiac muscle tissue growth +is_a: GO:0061117 ! negative regulation of heart growth +relationship: negatively_regulates GO:0055017 ! cardiac muscle tissue growth + +[Term] +id: GO:0055023 +name: positive regulation of cardiac muscle tissue growth +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth." [GOC:vk] +synonym: "activation of cardiac muscle growth" NARROW [] +synonym: "positive regulation of heart muscle growth" EXACT [] +synonym: "stimulation of cardiac muscle growth" NARROW [] +synonym: "up regulation of cardiac muscle growth" EXACT [] +synonym: "up-regulation of cardiac muscle growth" EXACT [] +synonym: "upregulation of cardiac muscle growth" EXACT [] +is_a: GO:0055021 ! regulation of cardiac muscle tissue growth +is_a: GO:0060421 ! positive regulation of heart growth +relationship: positively_regulates GO:0055017 ! cardiac muscle tissue growth + +[Term] +id: GO:0055024 +name: regulation of cardiac muscle tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] +synonym: "regulation of heart muscle development" EXACT [] +is_a: GO:0016202 ! regulation of striated muscle tissue development +relationship: regulates GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0055025 +name: positive regulation of cardiac muscle tissue development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] +synonym: "activation of cardiac muscle development" NARROW [] +synonym: "positive regulation of heart muscle development" EXACT [] +synonym: "stimulation of cardiac muscle development" NARROW [] +synonym: "up regulation of cardiac muscle development" EXACT [] +synonym: "up-regulation of cardiac muscle development" EXACT [] +synonym: "upregulation of cardiac muscle development" EXACT [] +is_a: GO:0045844 ! positive regulation of striated muscle tissue development +is_a: GO:0055024 ! regulation of cardiac muscle tissue development +relationship: positively_regulates GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0055026 +name: negative regulation of cardiac muscle tissue development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development." [GOC:vk] +synonym: "down regulation of cardiac muscle development" EXACT [] +synonym: "down-regulation of cardiac muscle development" EXACT [] +synonym: "downregulation of cardiac muscle development" EXACT [] +synonym: "inhibition of cardiac muscle development" NARROW [] +synonym: "negative regulation of heart muscle development" EXACT [] +is_a: GO:0045843 ! negative regulation of striated muscle tissue development +is_a: GO:0055024 ! regulation of cardiac muscle tissue development +relationship: negatively_regulates GO:0048738 ! cardiac muscle tissue development + +[Term] +id: GO:0055028 +name: cortical microtubule +namespace: cellular_component +def: "Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol." [GOC:mtg_sensu] +is_a: GO:0005881 ! cytoplasmic microtubule +relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton + +[Term] +id: GO:0055029 +name: nuclear DNA-directed RNA polymerase complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity." [GOC:mtg_sensu] +is_a: GO:0000428 ! DNA-directed RNA polymerase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0055034 +name: Bolwig's organ development +namespace: biological_process +def: "The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [GOC:mtg_sensu] +is_a: GO:0001654 ! eye development + +[Term] +id: GO:0055035 +name: plastid thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within a plastid." [GOC:jid, GOC:rph] +is_a: GO:0042170 ! plastid membrane +is_a: GO:0042651 ! thylakoid membrane +relationship: part_of GO:0031976 ! plastid thylakoid + +[Term] +id: GO:0055036 +name: virion membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106] +subset: goslim_chembl +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0055037 +name: recycling endosome +namespace: cellular_component +def: "An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane." [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] +synonym: "endosomal recycling compartment" EXACT [PMID:20820847] +synonym: "endosome recycling compartment" RELATED [GOC:dph, PMID:12370264] +synonym: "ERC" RELATED [GOC:dph, PMID:1237064] +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0055038 +name: recycling endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a recycling endosome." [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0055037 ! recycling endosome + +[Term] +id: GO:0055039 +name: trichocyst +namespace: cellular_component +def: "A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft." [GOC:jid, GOC:rph, http://www.iscid.org/encyclopedia/, PMID:3667715] +xref: Wikipedia:Trichocyst +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0055040 +name: periplasmic flagellum +namespace: cellular_component +def: "Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella." [GOC:jid, GOC:rph, PMID:15175283, PMID:1624463] +is_a: GO:0009288 ! bacterial-type flagellum +relationship: part_of GO:0042597 ! periplasmic space + +[Term] +id: GO:0055041 +name: cyclopentanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH." [EC:1.1.1.163, RHEA:11728] +synonym: "cyclopentanol:NAD+ oxidoreductase activity" RELATED [EC:1.1.1.163] +synonym: "cyclopentanol:NADP+ oxidoreductase activity" RELATED [EC:1.1.1.163] +xref: EC:1.1.1.163 +xref: KEGG_REACTION:R02553 +xref: MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN +xref: RHEA:11728 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0055042 +name: 5-valerolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate." [GOC:jid, GOC:mlg] +is_a: GO:0046573 ! lactonohydrolase activity + +[Term] +id: GO:0055043 +name: 5-oxovalerate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+." [GOC:jid, GOC:mlg] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0055044 +name: symplast +namespace: cellular_component +def: "The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata." [GOC:mtg_sensu] +subset: goslim_pir +xref: Wikipedia:Symplast +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0055045 +name: antipodal cell degeneration +namespace: biological_process +def: "The process in which the antipodal cells undergo programmed cell death." [GOC:mtg_plant] +is_a: GO:0010623 ! programmed cell death involved in cell development +relationship: part_of GO:0009561 ! megagametogenesis + +[Term] +id: GO:0055046 +name: microgametogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure." [GOC:mtg_plant] +synonym: "pollen development from the microspore" EXACT systematic_synonym [] +xref: Wikipedia:Microgametogenesis +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0009555 ! pollen development + +[Term] +id: GO:0055047 +name: generative cell mitosis +namespace: biological_process +def: "The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells." [GOC:mtg_plant] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0140014 ! mitotic nuclear division +relationship: part_of GO:0048232 ! male gamete generation + +[Term] +id: GO:0055048 +name: anastral spindle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins." [GOC:expert_rg, GOC:mtg_sensu, GOC:tb, PMID:15034926] +is_a: GO:0051225 ! spindle assembly + +[Term] +id: GO:0055049 +name: astral spindle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes." [GOC:tb] +is_a: GO:0051225 ! spindle assembly + +[Term] +id: GO:0055050 +name: astral spindle assembly involved in male meiosis +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the astral spindle in male meiotic cells." [GOC:tb] +is_a: GO:0007053 ! spindle assembly involved in male meiosis +is_a: GO:0055049 ! astral spindle assembly + +[Term] +id: GO:0055051 +name: ATP-binding cassette (ABC) transporter complex, integrated substrate binding +namespace: cellular_component +def: "A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:0055052 +name: ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing +namespace: cellular_component +def: "A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP." [GOC:mlg, GOC:mtg_sensu] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:0055053 +name: mannose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: mannose + H+ = mannose + H+." [GOC:ct] +synonym: "mannose:hydrogen symporter activity" EXACT [] +is_a: GO:0009679 ! hexose:proton symporter activity +is_a: GO:0015578 ! mannose transmembrane transporter activity + +[Term] +id: GO:0055054 +name: fructose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose + H+ = fructose + H+." [GOC:ct] +synonym: "fructose:hydrogen symporter activity" EXACT [] +is_a: GO:0005353 ! fructose transmembrane transporter activity +is_a: GO:0009679 ! hexose:proton symporter activity + +[Term] +id: GO:0055055 +name: D-glucose:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-glucose + H+ = D-glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. D-glucose is the dextrorotatory D-enantiomer of glucose." [GOC:ct] +synonym: "D-glucose:hydrogen symporter activity" EXACT [] +is_a: GO:0005356 ! glucose:proton symporter activity +is_a: GO:0055056 ! D-glucose transmembrane transporter activity + +[Term] +id: GO:0055056 +name: D-glucose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:jid, GOC:jsg, GOC:mah] +xref: Reactome:R-HSA-429094 "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-450095 "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region" +xref: Reactome:R-HSA-5339524 "GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-5632804 "SLC2A1 tetramer does not transport Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-5632871 "Defective SLC2A10 does not transport Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8981553 "GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8981564 "GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8981570 "GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol" +xref: Reactome:R-HSA-8981574 "GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol" +is_a: GO:0005355 ! glucose transmembrane transporter activity + +[Term] +id: GO:0055057 +name: neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron." [PMID:11163136, PMID:11250167] +synonym: "neuroblast cell division" EXACT [] +is_a: GO:0051301 ! cell division +relationship: part_of GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:0055058 +name: symmetric neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells." [GOC:dph] +is_a: GO:0055057 ! neuroblast division + +[Term] +id: GO:0055059 +name: asymmetric neuroblast division +namespace: biological_process +def: "The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials." [GOC:dph] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0045165 ! cell fate commitment +is_a: GO:0055057 ! neuroblast division + +[Term] +id: GO:0055060 +name: asymmetric neuroblast division resulting in ganglion mother cell formation +namespace: biological_process +def: "Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell." [GOC:dph] +is_a: GO:0014017 ! neuroblast fate commitment +is_a: GO:0055059 ! asymmetric neuroblast division + +[Term] +id: GO:0055061 +name: obsolete di-, tri-valent inorganic anion homeostasis +namespace: biological_process +def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +comment: This term was made obsolete because it has been split. +synonym: "di-, tri-valent inorganic anion homeostasis" EXACT [] +is_obsolete: true +consider: GO:0072505 +consider: GO:0072506 + +[Term] +id: GO:0055062 +name: phosphate ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell." [GOC:jid, GOC:mah] +is_a: GO:0072506 ! trivalent inorganic anion homeostasis + +[Term] +id: GO:0055063 +name: sulfate ion homeostasis +namespace: biological_process +alt_id: GO:0080174 +def: "Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell." [GOC:jid, GOC:mah] +synonym: "sulfate homeostasis" EXACT [] +synonym: "sulphate ion homeostasis" EXACT [] +is_a: GO:0072505 ! divalent inorganic anion homeostasis + +[Term] +id: GO:0055064 +name: chloride ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell." [GOC:jid, GOC:mah] +is_a: GO:0055083 ! monovalent inorganic anion homeostasis + +[Term] +id: GO:0055065 +name: metal ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +subset: goslim_generic +subset: goslim_pombe +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0055066 +name: obsolete di-, tri-valent inorganic cation homeostasis +namespace: biological_process +def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] +comment: This term was made obsolete because it has been split. +synonym: "di-, tri-valent inorganic cation homeostasis" EXACT [] +is_obsolete: true +consider: GO:0072507 +consider: GO:0072508 + +[Term] +id: GO:0055067 +name: monovalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0055068 +name: cobalt ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +synonym: "cobalt homeostasis" BROAD [] +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0055069 +name: zinc ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +synonym: "zinc homeostasis" BROAD [] +is_a: GO:0055076 ! transition metal ion homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0055070 +name: copper ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +synonym: "copper homeostasis" BROAD [] +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0055071 +name: manganese ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell." [GOC:jid, GOC:mah] +synonym: "manganese homeostasis" BROAD [] +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0055072 +name: iron ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +synonym: "iron homeostasis" BROAD [] +is_a: GO:0055076 ! transition metal ion homeostasis + +[Term] +id: GO:0055073 +name: cadmium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +synonym: "cadmium homeostasis" EXACT [] +is_a: GO:0055076 ! transition metal ion homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0055074 +name: calcium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] +synonym: "regulation of calcium ion concentration" EXACT [] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0055075 +name: potassium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell." [GOC:jid, GOC:mah] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0055076 +name: transition metal ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [GOC:jid, GOC:mah, ISBN:0198506732] +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0055077 +name: gap junction hemi-channel activity +namespace: molecular_function +def: "A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction." [GOC:dgh] +synonym: "connexon channel activity" EXACT [] +is_a: GO:0022829 ! wide pore channel activity +relationship: part_of GO:0005243 ! gap junction channel activity + +[Term] +id: GO:0055078 +name: sodium ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +is_a: GO:0055065 ! metal ion homeostasis +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0055079 +name: aluminum ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell." [GOC:jid, GOC:lr, GOC:mah] +synonym: "aluminium ion homeostasis" EXACT [GOC:mah] +is_a: GO:0055065 ! metal ion homeostasis + +[Term] +id: GO:0055080 +name: cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cations within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0055081 +name: anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of anions within an organism or cell." [GOC:ceb, GOC:jid, GOC:mah] +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0055082 +name: cellular chemical homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0055083 +name: monovalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell." [GOC:ai, GOC:jid, GOC:mah] +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0055085 +name: transmembrane transport +namespace: biological_process +alt_id: GO:0090662 +def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] +comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "ATP hydrolysis coupled transmembrane transport" NARROW [] +synonym: "membrane transport" EXACT [] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0055086 +name: nucleobase-containing small molecule metabolic process +namespace: biological_process +def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] +synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0055087 +name: Ski complex +namespace: cellular_component +def: "A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p." [GOC:mcc, PMID:10744028, PMID:15703439, PMID:16043509, PMID:18042677] +xref: Wikipedia:Ski_complex +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0055088 +name: lipid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of lipid within an organism or cell." [GOC:BHF, GOC:rl] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0055089 +name: fatty acid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell." [GOC:BHF, GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055090 +name: acylglycerol homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of acylglycerol within an organism or cell." [GOC:BHF, GOC:rl] +synonym: "glyceride homeostasis" EXACT [] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055091 +name: phospholipid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell." [GOC:BHF, GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055092 +name: sterol homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sterol within an organism or cell." [GOC:BHF, GOC:rl] +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0055093 +name: response to hyperoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:kmv] +synonym: "response to hyperoxic stress" EXACT [] +synonym: "response to increased oxygen tension" EXACT [] +is_a: GO:0006950 ! response to stress +is_a: GO:0036296 ! response to increased oxygen levels + +[Term] +id: GO:0055094 +name: response to lipoprotein particle +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:BHF, GOC:rl] +synonym: "response to lipoprotein particle stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0055095 +name: lipoprotein particle mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of a lipoprotein particle." [GOC:BHF, GOC:rl] +synonym: "lipoprotein mediated signalling" EXACT [] +synonym: "lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] +synonym: "lipoprotein particle-mediated signaling" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0071402 ! cellular response to lipoprotein particle stimulus + +[Term] +id: GO:0055096 +name: low-density lipoprotein particle mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of low-density lipoprotein particle." [GOC:BHF, GOC:rl, PMID:16013438] +synonym: "low-density lipoprotein mediated signalling" EXACT [] +synonym: "low-density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] +synonym: "low-density lipoprotein particle-mediated signaling" EXACT [] +is_a: GO:0055095 ! lipoprotein particle mediated signaling +relationship: part_of GO:0071404 ! cellular response to low-density lipoprotein particle stimulus + +[Term] +id: GO:0055097 +name: high density lipoprotein particle mediated signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of high density lipoprotein particle." [GOC:BHF, GOC:rl] +synonym: "high density lipoprotein mediated signalling" EXACT [] +synonym: "high density lipoprotein particle mediated signal transduction" EXACT [GOC:signaling] +synonym: "high density lipoprotein particle-mediated signaling" EXACT [] +is_a: GO:0055095 ! lipoprotein particle mediated signaling +relationship: part_of GO:0071403 ! cellular response to high density lipoprotein particle stimulus + +[Term] +id: GO:0055100 +name: adiponectin binding +namespace: molecular_function +def: "Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism." [GOC:BHF, GOC:rl, PMID:15210937] +is_a: GO:0005515 ! protein binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0055101 +name: obsolete glycerophospholipase inhibitor activity +namespace: molecular_function +def: "OBSOLETE. Stops, prevents or reduces the activity of a glycerophospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai, GOC:BHF, GOC:rl] +comment: This term was made obsolete because it refers to a non-existent molecular function term, 'glycerophosphate activity', which also cannot be found in the literature. +synonym: "glycerophospholipase inhibitor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0055102 +name: lipase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:rl] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0055103 +name: ligase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a ligase." [GOC:BHF, GOC:rl] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0055104 +name: ligase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a ligase." [GOC:BHF, GOC:rl] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0055103 ! ligase regulator activity + +[Term] +id: GO:0055105 +name: ubiquitin-protein transferase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase." [GOC:BHF, GOC:rl] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity + +[Term] +id: GO:0055106 +name: ubiquitin-protein transferase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:BHF, GOC:rl] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0055107 +name: Golgi to secretory granule transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex." [GOC:curators] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:0055108 +name: Golgi to transport vesicle transport +namespace: biological_process +def: "The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis." [GOC:jid] +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0055109 +name: invagination involved in gastrulation with mouth forming second +namespace: biological_process +def: "The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055110 +name: involution involved in gastrulation with mouth forming second +namespace: biological_process +def: "The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055111 +name: ingression involved in gastrulation with mouth forming second +namespace: biological_process +def: "The migration of individual cells into the embryo involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055112 +name: delamination involved in gastrulation with mouth forming second +namespace: biological_process +def: "The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0060232 ! delamination +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055113 +name: epiboly involved in gastrulation with mouth forming second +namespace: biological_process +def: "The expansion of one cell sheet over other cells involved in deuterostomic gastrulation." [ISBN:0878932437] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0090504 ! epiboly +relationship: part_of GO:0001702 ! gastrulation with mouth forming second + +[Term] +id: GO:0055114 +name: obsolete oxidation-reduction process +namespace: biological_process +def: "OBSOLETE. A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] +comment: This term was obsoleted because it represents a molecular function. +synonym: "oxidation reduction" EXACT [] +synonym: "oxidoreductase process" EXACT systematic_synonym [] +is_obsolete: true + +[Term] +id: GO:0055115 +name: entry into diapause +namespace: biological_process +def: "The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:ds, GOC:jid, GOC:mah] +xref: Wikipedia:Diapause +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0055116 +name: entry into reproductive diapause +namespace: biological_process +def: "The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ds, GOC:jid, GOC:mah] +is_a: GO:0055115 ! entry into diapause + +[Term] +id: GO:0055117 +name: regulation of cardiac muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] +is_a: GO:0006942 ! regulation of striated muscle contraction +is_a: GO:0008016 ! regulation of heart contraction +relationship: regulates GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0055118 +name: negative regulation of cardiac muscle contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction." [GOC:ecd] +is_a: GO:0045822 ! negative regulation of heart contraction +is_a: GO:0045988 ! negative regulation of striated muscle contraction +is_a: GO:0055117 ! regulation of cardiac muscle contraction +relationship: negatively_regulates GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0055119 +name: relaxation of cardiac muscle +namespace: biological_process +def: "The process in which the extent of cardiac muscle contraction is reduced." [GOC:ecd] +is_a: GO:0090075 ! relaxation of muscle + +[Term] +id: GO:0055120 +name: striated muscle dense body +namespace: cellular_component +def: "A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere." [GOC:kmv, PMID:17492481] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043292 ! contractile fiber + +[Term] +id: GO:0055121 +name: response to high fluence blue light stimulus by blue high-fluence system +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2." [GOC:mtg_far_red] +synonym: "response to high fluence blue light" BROAD [] +synonym: "response to high fluence blue light by bhf system" RELATED [] +is_a: GO:0009637 ! response to blue light +is_a: GO:0009644 ! response to high light intensity + +[Term] +id: GO:0055122 +name: response to very low light intensity stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mtg_far_red] +is_a: GO:0009642 ! response to light intensity + +[Term] +id: GO:0055123 +name: digestive system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jid] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0055124 +name: obsolete premature neural plate formation +namespace: biological_process +def: "OBSOLETE. The formation of the neural plate before the appropriate time." [GOC:jid] +synonym: "premature neural plate formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0055125 +name: obsolete Nic96 complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex, and is required for its correct assembly. In Saccharomyces cerevisiae Nic96 contains Nsp1p, Nup57p, Nup49p, and Nic96p." [GOC:jh, PMID:12791264, PMID:15741174] +synonym: "Nic96 complex" EXACT [] +is_obsolete: true +consider: GO:0044612 + +[Term] +id: GO:0055126 +name: obsolete Nup82 complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that forms part of the nuclear pore complex. It forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p, and is required for proper localization of Nup116p. In Saccharomyces cerevisiae this complex contains Nup82p, Nsp1p, Nup159p, Nup116p, and Gle2p." [GOC:jh, PMID:12791264, PMID:15741174] +synonym: "Nup82 complex" EXACT [] +is_obsolete: true +consider: GO:0044612 + +[Term] +id: GO:0055127 +name: vibrational conductance of sound to the inner ear +namespace: biological_process +def: "The transmission of vibrations via ossicles to the inner ear." [GOC:mh] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0007605 ! sensory perception of sound + +[Term] +id: GO:0055129 +name: L-proline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:ecd] +synonym: "pyrrolidine-2-carboxylic acid biosynthetic process" BROAD [] +is_a: GO:0006561 ! proline biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0055130 +name: D-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-alanine, the D-enantiomer of the amino acid alanine." [GOC:ecd] +synonym: "(2R)-2-aminopropanoic acid catabolic process" EXACT [] +is_a: GO:0006524 ! alanine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:0046436 ! D-alanine metabolic process + +[Term] +id: GO:0055131 +name: C3HC4-type RING finger domain binding +namespace: molecular_function +def: "Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway." [GOC:amm, InterPro:IPR001841, InterPro:IPR018957] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0060001 +name: minus-end directed microfilament motor activity +namespace: molecular_function +def: "A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] +synonym: "minus-end directed actin filament motor activity" RELATED [GOC:dph] +synonym: "minus-end directed actin-filament motor activity" EXACT [GOC:dph] +synonym: "pointed-end directed actin-filament motor activity" EXACT [GOC:dph] +is_a: GO:0000146 ! microfilament motor activity + +[Term] +id: GO:0060002 +name: plus-end directed microfilament motor activity +namespace: molecular_function +def: "A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers." [GOC:dph, PMID:10519557] +synonym: "barbed-end directed actin-filament motor activity" EXACT [GOC:dph] +synonym: "plus-end directed actin filament motor activity" RELATED [GOC:dph] +synonym: "plus-end directed actin-filament motor activity" EXACT [GOC:dph] +is_a: GO:0000146 ! microfilament motor activity + +[Term] +id: GO:0060003 +name: copper ion export +namespace: biological_process +def: "The directed movement of copper ions out of a cell or organelle." [GOC:dph] +synonym: "copper export" EXACT [GOC:dph] +is_a: GO:0035434 ! copper ion transmembrane transport +is_a: GO:0070839 ! metal ion export + +[Term] +id: GO:0060004 +name: reflex +namespace: biological_process +def: "An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness." [GOC:dph, ISBN:0877797099] +xref: Wikipedia:Reflex +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0060005 +name: vestibular reflex +namespace: biological_process +def: "A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [PMID:11784757] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060006 +name: angular vestibuloocular reflex +namespace: biological_process +def: "A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] +is_a: GO:0060005 ! vestibular reflex + +[Term] +id: GO:0060007 +name: linear vestibuloocular reflex +namespace: biological_process +def: "A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness." [GOC:dph, PMID:11784757] +is_a: GO:0060005 ! vestibular reflex + +[Term] +id: GO:0060008 +name: Sertoli cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0060009 +name: Sertoli cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0060008 ! Sertoli cell differentiation + +[Term] +id: GO:0060010 +name: Sertoli cell fate commitment +namespace: biological_process +def: "The process in which the cellular identity of Sertoli cells is acquired and determined." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0060008 ! Sertoli cell differentiation + +[Term] +id: GO:0060011 +name: Sertoli cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules." [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0060012 +name: synaptic transmission, glycinergic +namespace: biological_process +def: "The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos] +synonym: "glycinergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0060013 +name: righting reflex +namespace: biological_process +def: "A reflex process in which an animal immediately tries to turn over after being placed in a supine position." [GOC:dph, PMID:8635460] +synonym: "righting response" EXACT [GOC:dph] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060014 +name: granulosa cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals." [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0060015 +name: granulosa cell fate commitment +namespace: biological_process +def: "The cell fate commitment of precursor cells that will become granulosa cells." [GOC:dph] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0060014 ! granulosa cell differentiation + +[Term] +id: GO:0060016 +name: granulosa cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate." [GOC:dph] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0060014 ! granulosa cell differentiation + +[Term] +id: GO:0060017 +name: parathyroid gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone." [GOC:dph, ISBN:0721662544] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0035270 ! endocrine system development + +[Term] +id: GO:0060018 +name: astrocyte fate commitment +namespace: biological_process +def: "The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte." [GOC:dph] +is_a: GO:0021781 ! glial cell fate commitment +relationship: part_of GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0060019 +name: radial glial cell differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph] +is_a: GO:0010001 ! glial cell differentiation + +[Term] +id: GO:0060020 +name: Bergmann glial cell differentiation +namespace: biological_process +def: "The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, PMID:10375501] +is_a: GO:0048708 ! astrocyte differentiation + +[Term] +id: GO:0060021 +name: roof of mouth development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities." [GOC:dph, ISBN:0721662544] +synonym: "palatum development" EXACT [ISBN:0721662544] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0060022 +name: hard palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes." [GOC:dph, ISBN:0721662544] +synonym: "palatum durum development" EXACT [ISBN:0721662544] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0062009 ! secondary palate development + +[Term] +id: GO:0060023 +name: soft palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate." [GOC:dph, ISBN:0721662544] +synonym: "palatum molle development" EXACT [ISBN:0721662544] +synonym: "velum palatum development" EXACT [ISBN:0721662544] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0062009 ! secondary palate development + +[Term] +id: GO:0060024 +name: rhythmic synaptic transmission +namespace: biological_process +def: "Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit." [GOC:dph] +is_a: GO:0050804 ! modulation of chemical synaptic transmission + +[Term] +id: GO:0060025 +name: regulation of synaptic activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell." [GOC:dph, GOC:tb] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: part_of GO:0050803 ! regulation of synapse structure or activity + +[Term] +id: GO:0060026 +name: convergent extension +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis." [GOC:dgf, GOC:dph, PMID:12062082] +xref: Wikipedia:Convergent_extension +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0060027 +name: convergent extension involved in gastrulation +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:dph, PMID:12062082] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0060028 +name: convergent extension involved in axis elongation +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contributing to the lengthening of the axis of an organism." [GOC:dph, PMID:12062082] +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0003401 ! axis elongation + +[Term] +id: GO:0060029 +name: convergent extension involved in organogenesis +namespace: biological_process +def: "The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ." [GOC:dph, PMID:12062082] +is_a: GO:0060026 ! convergent extension +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0060030 +name: dorsal convergence +namespace: biological_process +def: "The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement." [GOC:dgf, GOC:dph, PMID:12062082] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:0060031 +name: mediolateral intercalation +namespace: biological_process +def: "The interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dgf, GOC:dph, PMID:12062082] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:0060032 +name: notochord regression +namespace: biological_process +def: "The developmental process in which the stucture of the notochord is destroyed in an embryo." [GOC:dph] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0048570 ! notochord morphogenesis + +[Term] +id: GO:0060033 +name: anatomical structure regression +namespace: biological_process +def: "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph] +synonym: "histolysis" RELATED [GOC:mtg_apoptosis] +synonym: "tissue death" RELATED [GOC:mtg_apoptosis] +is_a: GO:0032502 ! developmental process +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0060034 +name: notochord cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030903 ! notochord development + +[Term] +id: GO:0060035 +name: notochord cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060034 ! notochord cell differentiation + +[Term] +id: GO:0060036 +name: notochord cell vacuolation +namespace: biological_process +def: "The assembly and arrangement of a vacuole within a cell of the notochord." [GOC:cb, GOC:dph, PMID:10964477] +is_a: GO:0007033 ! vacuole organization +relationship: part_of GO:0060035 ! notochord cell development + +[Term] +id: GO:0060037 +name: pharyngeal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear." [GOC:dph] +is_a: GO:0048731 ! system development +relationship: part_of GO:0043009 ! chordate embryonic development + +[Term] +id: GO:0060038 +name: cardiac muscle cell proliferation +namespace: biological_process +def: "The expansion of a cardiac muscle cell population by cell division." [GOC:dph, GOC:rph, PMID:11161571] +synonym: "cardiac myocyte proliferation" EXACT [] +synonym: "cardiomyocyte proliferation" RELATED [GOC:dph, PMID:10074473] +synonym: "heart muscle cell proliferation" EXACT [] +is_a: GO:0014855 ! striated muscle cell proliferation +relationship: part_of GO:0055017 ! cardiac muscle tissue growth + +[Term] +id: GO:0060039 +name: pericardium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery." [GOC:dph, GOC:rph, PMID:15138308, PMID:16376438] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060040 +name: retinal bipolar neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] +is_a: GO:1905962 ! glutamatergic neuron differentiation +relationship: part_of GO:0003407 ! neural retina development +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060041 +name: retina development in camera-type eye +namespace: biological_process +alt_id: GO:0002073 +def: "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates." [GOC:bf, GOC:dph, ISBN:0815340729] +synonym: "retina development in camera-style eye" EXACT [] +synonym: "retinal development" RELATED [GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0060042 +name: retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process in which the anatomical structure of the retina is generated and organized." [GOC:bf, GOC:dph, GOC:mtg_sensu] +synonym: "retina morphogenesis in camera-style eye" EXACT [] +synonym: "retinogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048593 ! camera-type eye morphogenesis +relationship: part_of GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:0060043 +name: regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] +synonym: "regulation of cardiomyocyte proliferation" RELATED [GOC:dph] +synonym: "regulation of heart muscle cell proliferation" EXACT [] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0055021 ! regulation of cardiac muscle tissue growth +relationship: regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060044 +name: negative regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] +synonym: "negative regulation of heart muscle cell proliferation" EXACT [] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth +is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation +relationship: negatively_regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060045 +name: positive regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation." [GOC:dph, GOC:rph] +synonym: "positive regulation of heart muscle cell proliferation" RELATED [] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth +is_a: GO:0060043 ! regulation of cardiac muscle cell proliferation +relationship: positively_regulates GO:0060038 ! cardiac muscle cell proliferation + +[Term] +id: GO:0060046 +name: regulation of acrosome reaction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the acrosome reaction." [GOC:dph] +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007340 ! acrosome reaction + +[Term] +id: GO:0060047 +name: heart contraction +namespace: biological_process +def: "The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph] +synonym: "cardiac contraction" RELATED [] +synonym: "heart beating" EXACT [] +synonym: "hemolymph circulation" RELATED [] +is_a: GO:0003015 ! heart process +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0060048 +name: cardiac muscle contraction +namespace: biological_process +def: "Muscle contraction of cardiac muscle tissue." [GOC:dph] +synonym: "heart muscle contraction" EXACT [] +is_a: GO:0006941 ! striated muscle contraction +relationship: part_of GO:0060047 ! heart contraction + +[Term] +id: GO:0060049 +name: regulation of protein glycosylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] +synonym: "regulation of protein amino acid glycosylation" EXACT [GOC:bf] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0006486 ! protein glycosylation + +[Term] +id: GO:0060050 +name: positive regulation of protein glycosylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] +synonym: "positive regulation of protein amino acid glycosylation" EXACT [GOC:bf] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0060049 ! regulation of protein glycosylation +relationship: positively_regulates GO:0006486 ! protein glycosylation + +[Term] +id: GO:0060051 +name: negative regulation of protein glycosylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:dms, GOC:dph, GOC:pr] +synonym: "negative regulation of protein amino acid glycosylation" EXACT [GOC:bf] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0060049 ! regulation of protein glycosylation +relationship: negatively_regulates GO:0006486 ! protein glycosylation + +[Term] +id: GO:0060052 +name: neurofilament cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising neurofilaments and their associated proteins." [GOC:dph] +synonym: "neurofilament cytoskeleton organisation" EXACT [GOC:mah] +synonym: "neurofilament cytoskeleton organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0045104 ! intermediate filament cytoskeleton organization + +[Term] +id: GO:0060053 +name: neurofilament cytoskeleton +namespace: cellular_component +def: "Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons." [GOC:dph] +is_a: GO:0045111 ! intermediate filament cytoskeleton + +[Term] +id: GO:0060054 +name: positive regulation of epithelial cell proliferation involved in wound healing +namespace: biological_process +def: "Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury." [GOC:dph] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0060055 +name: angiogenesis involved in wound healing +namespace: biological_process +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph, PMID:15039218] +is_a: GO:0001525 ! angiogenesis +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0060056 +name: mammary gland involution +namespace: biological_process +def: "The tissue remodeling that removes differentiated mammary epithelia during weaning." [GOC:dph, PMID:15282149] +is_a: GO:0048771 ! tissue remodeling +relationship: part_of GO:0060443 ! mammary gland morphogenesis + +[Term] +id: GO:0060057 +name: apoptotic process involved in mammary gland involution +namespace: biological_process +def: "Any apoptotic process that triggers the activity of proteolytic caspases whose actions dismantle the mammary epithelial cells resulting in their programmed cell death." [GOC:dph, GOC:mtg_apoptosis] +synonym: "apoptosis involved in mammary gland involution" NARROW [] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +relationship: part_of GO:0060056 ! mammary gland involution + +[Term] +id: GO:0060058 +name: positive regulation of apoptotic process involved in mammary gland involution +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution." [GOC:dph, GOC:mtg_apoptosis, PMID:15282149] +synonym: "positive regulation of apoptosis involved in mammary gland involution" NARROW [] +is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis +relationship: positively_regulates GO:0060057 ! apoptotic process involved in mammary gland involution + +[Term] +id: GO:0060059 +name: embryonic retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage." [GOC:dgh, GOC:dph] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060060 +name: post-embryonic retina morphogenesis in camera-type eye +namespace: biological_process +def: "The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage." [GOC:dgh, GOC:dph] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060061 +name: Spemann organizer formation +namespace: biological_process +def: "Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:bf, GOC:dph] +synonym: "Spemann's organizer formation" EXACT [] +synonym: "Spemann-Mangold organizer formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0031128 ! developmental induction + +[Term] +id: GO:0060062 +name: Spemann organizer formation at the dorsal lip of the blastopore +namespace: biological_process +def: "Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan." [GOC:dph, PMID:9442883] +comment: Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. +synonym: "Spemann's organizer formation at the dorsal lip of the blastopore" EXACT [] +synonym: "Spemann-Mangold organizer formation at the dorsal lip of the blastopore" EXACT [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060063 +name: Spemann organizer formation at the embryonic shield +namespace: biological_process +def: "Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan." [GOC:dph, PMID:9442883] +comment: Occurs in Teleost fish. +synonym: "Spemann's organizer formation at the embryonic shield" EXACT [] +synonym: "Spemann-Mangold organizer formation at the embryonic shield" EXACT [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060064 +name: Spemann organizer formation at the anterior end of the primitive streak +namespace: biological_process +def: "Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan." [GOC:dph, PMID:9442883] +comment: Occurs in reptiles, birds and mammals. +synonym: "Spemann organizer formation in amniotes" RELATED [] +synonym: "Spemann's organizer formation at the anterior end of the primitive streak" EXACT [] +synonym: "Spemann-Mangold organizer formation at the anterior end of the primitive streak" RELATED [] +is_a: GO:0060061 ! Spemann organizer formation + +[Term] +id: GO:0060065 +name: uterus development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0048513 ! animal organ development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060066 +name: oviduct development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism." [GOC:dph, GOC:ebc, http://www.thefreedictionary.com/oviduct] +synonym: "fallopian tube development" NARROW [GOC:bf] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0035295 ! tube development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060067 +name: cervix development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] +synonym: "Mullerian tract development" RELATED [] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0060068 +name: vagina development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure." [GOC:dph, GOC:ebc] +is_a: GO:0030540 ! female genitalia development + +[Term] +id: GO:0060069 +name: Wnt signaling pathway, regulating spindle positioning +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle." [GOC:bf, GOC:dph, PMID:11532397] +synonym: "non-canonical Wnt signaling pathway" BROAD [] +synonym: "Wnt receptor signaling pathway, regulating spindle positioning" EXACT [] +synonym: "Wnt receptor signalling pathway, regulating spindle positioning" EXACT [] +synonym: "Wnt-activated signaling pathway, regulating spindle positioning" EXACT [GOC:signaling] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0035567 ! non-canonical Wnt signaling pathway +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization +relationship: regulates GO:0040001 ! establishment of mitotic spindle localization + +[Term] +id: GO:0060070 +name: canonical Wnt signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488] +synonym: "canonical Wnt receptor signaling pathway" EXACT [GOC:signaling] +synonym: "canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "frizzled-1 receptor signaling pathway" NARROW [] +synonym: "Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] +synonym: "Wnt receptor signaling pathway via beta-catenin" EXACT [] +synonym: "Wnt receptor signalling pathway through beta-catenin" EXACT [] +is_a: GO:0016055 ! Wnt signaling pathway + +[Term] +id: GO:0060071 +name: Wnt signaling pathway, planar cell polarity pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity." [GOC:bf, GOC:dph, PMID:11532397] +synonym: "non-canonical Wnt signaling pathway" RELATED [GOC:bf] +synonym: "PCP pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "planar cell polarity pathway" EXACT [GOC:cjm] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] +synonym: "Wnt-JNK signaling pathway" RELATED [GOC:bf] +synonym: "Wnt-PCP signaling pathway" RELATED [GOC:rph] +is_a: GO:0035567 ! non-canonical Wnt signaling pathway +is_a: GO:0090175 ! regulation of establishment of planar polarity + +[Term] +id: GO:0060072 +name: large conductance calcium-activated potassium channel activity +namespace: molecular_function +alt_id: GO:0022895 +def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729, PMID:17115074] +synonym: "BK calcium-activated potassium channel activity" EXACT [] +synonym: "BK channel activity" RELATED [] +synonym: "BK KCa channel activity" EXACT [] +synonym: "large conductance KCa channel activity" EXACT [] +is_a: GO:0015269 ! calcium-activated potassium channel activity + +[Term] +id: GO:0060073 +name: micturition +namespace: biological_process +def: "The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body." [GOC:dph] +synonym: "urination" EXACT [] +synonym: "urine voiding" EXACT [] +xref: Wikipedia:Urination +is_a: GO:0003014 ! renal system process +is_a: GO:0007588 ! excretion + +[Term] +id: GO:0060074 +name: synapse maturation +namespace: biological_process +def: "The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development." [GOC:dph, GOC:ef] +subset: goslim_synapse +synonym: "synaptic maturation" EXACT [] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0050808 ! synapse organization +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0060075 +name: regulation of resting membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized." [GOC:dph, GOC:ef, ISBN:0195088433] +synonym: "regulation of resting potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060076 +name: excitatory synapse +namespace: cellular_component +def: "A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] +xref: Wikipedia:Excitatory_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0060077 +name: inhibitory synapse +namespace: cellular_component +def: "A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell." [GOC:dph, GOC:ef] +xref: Wikipedia:Inhibitory_postsynaptic_potential +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0060078 +name: regulation of postsynaptic membrane potential +namespace: biological_process +def: "Any process that modulates the potential difference across a post-synaptic membrane." [GOC:dph, GOC:ef] +subset: goslim_synapse +synonym: "regulation of post-synaptic membrane potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060079 +name: excitatory postsynaptic potential +namespace: biological_process +def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dph, GOC:ef] +synonym: "regulation of EPSP" RELATED [] +synonym: "regulation of excitatory post-synaptic membrane potential" EXACT [] +is_a: GO:0060078 ! regulation of postsynaptic membrane potential +relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic + +[Term] +id: GO:0060080 +name: inhibitory postsynaptic potential +namespace: biological_process +def: "A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dph, GOC:ef] +synonym: "IPSP" RELATED [] +synonym: "regulation of inhibitory post-synaptic membrane potential" EXACT [] +is_a: GO:0060078 ! regulation of postsynaptic membrane potential +relationship: part_of GO:0099565 ! chemical synaptic transmission, postsynaptic + +[Term] +id: GO:0060081 +name: membrane hyperpolarization +namespace: biological_process +def: "The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential." [GOC:dph] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0060082 +name: eye blink reflex +namespace: biological_process +def: "The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing." [GOC:dph, PMID:2913208] +synonym: "nictitating membrane reflex" EXACT [] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0060083 +name: smooth muscle contraction involved in micturition +namespace: biological_process +def: "The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body." [GOC:dph, PMID:15827347] +synonym: "smooth muscle contraction involved in urination" RELATED [] +synonym: "urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:dph] +is_a: GO:0014832 ! urinary bladder smooth muscle contraction +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060084 +name: synaptic transmission involved in micturition +namespace: biological_process +def: "The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] +synonym: "synaptic transmission involved in urination" RELATED [] +is_a: GO:0007274 ! neuromuscular synaptic transmission +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060085 +name: smooth muscle relaxation of the bladder outlet +namespace: biological_process +def: "A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body." [GOC:dph, PMID:15827347] +synonym: "synaptic transmission involved in urination" EXACT [] +is_a: GO:0044557 ! relaxation of smooth muscle +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +relationship: part_of GO:0060073 ! micturition + +[Term] +id: GO:0060086 +name: circadian temperature homeostasis +namespace: biological_process +def: "Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours." [GOC:dph, GOC:tb] +synonym: "circadian regulation of body temperature" RELATED [] +synonym: "circadian thermoregulation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001659 ! temperature homeostasis +is_a: GO:0007623 ! circadian rhythm + +[Term] +id: GO:0060087 +name: relaxation of vascular associated smooth muscle +namespace: biological_process +alt_id: GO:1905657 +alt_id: GO:1905658 +alt_id: GO:1905659 +def: "A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:dph, GOC:rph, GOC:TermGenie, PMID:15867178, PMID:19996365, PMID:27389411] +synonym: "negative regulation of relaxation of vascular smooth muscle" RELATED [] +synonym: "positive regulation of relaxation of vascular smooth muscle" RELATED [] +synonym: "regulation of relaxation of vascular smooth muscle" RELATED [] +synonym: "relaxation of vascular smooth muscle" EXACT [] +synonym: "vascular smooth muscle relaxation" EXACT [] +is_a: GO:0044557 ! relaxation of smooth muscle +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +relationship: part_of GO:0042311 ! vasodilation + +[Term] +id: GO:0060088 +name: auditory receptor cell stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells." [GOC:dph, PMID:10978835] +synonym: "auditory receptor cell stereocilium organisation" EXACT [] +synonym: "auditory receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0060122 ! inner ear receptor cell stereocilium organization +relationship: part_of GO:0002093 ! auditory receptor cell morphogenesis + +[Term] +id: GO:0060089 +name: molecular transducer activity +namespace: molecular_function +def: "A compound molecular function in which an effector function is controlled by one or more regulatory components." [GOC:dos, GOC:pdt] +subset: gocheck_do_not_manually_annotate +subset: goslim_generic +subset: goslim_pir +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0060090 +name: molecular adaptor activity +namespace: molecular_function +alt_id: GO:0032947 +def: "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +synonym: "binding, bridging" EXACT [] +synonym: "protein complex scaffold activity" RELATED [] +synonym: "protein-containing complex scaffold activity" RELATED [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0060091 +name: kinocilium +namespace: cellular_component +def: "A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia." [GOC:cilia, GOC:dph, PMID:15882574] +xref: Wikipedia:Kinocilium +is_a: GO:0043005 ! neuron projection +is_a: GO:0097732 ! 9+2 non-motile cilium +relationship: part_of GO:0032421 ! stereocilium bundle +relationship: part_of GO:0043226 ! organelle + +[Term] +id: GO:0060092 +name: regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060093 +name: negative regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that stops or decreases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "negative regulation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic +relationship: negatively_regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060094 +name: positive regulation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "positive regulation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic +relationship: positively_regulates GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0060095 +name: zinc potentiation of synaptic transmission, glycinergic +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine." [GOC:dms, GOC:dph] +synonym: "zinc potentiation of glycinergic synaptic transmission" EXACT [] +is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic + +[Term] +id: GO:0060096 +name: serotonin secretion, neurotransmission +namespace: biological_process +def: "The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter." [GOC:dph] +synonym: "serotonin release, neurotransmission" RELATED [GOC:tb] +is_a: GO:0001820 ! serotonin secretion +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0060097 +name: cytoskeletal rearrangement involved in phagocytosis, engulfment +namespace: biological_process +def: "The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0007010 ! cytoskeleton organization +relationship: part_of GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060098 +name: membrane reorganization involved in phagocytosis, engulfment +namespace: biological_process +def: "The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +synonym: "membrane reorganisation involved in phagocytosis, engulfment" EXACT [GOC:mah] +is_a: GO:0007009 ! plasma membrane organization +relationship: part_of GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060099 +name: regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0050764 ! regulation of phagocytosis +is_a: GO:1905153 ! regulation of membrane invagination +relationship: regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060100 +name: positive regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:0060099 ! regulation of phagocytosis, engulfment +is_a: GO:1905155 ! positive regulation of membrane invagination +relationship: positively_regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060101 +name: negative regulation of phagocytosis, engulfment +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis." [GOC:dph] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0050765 ! negative regulation of phagocytosis +is_a: GO:0060099 ! regulation of phagocytosis, engulfment +is_a: GO:1905154 ! negative regulation of membrane invagination +relationship: negatively_regulates GO:0006911 ! phagocytosis, engulfment + +[Term] +id: GO:0060102 +name: collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0060103 +name: obsolete collagen and cuticulin-based cuticle extracellular matrix part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the collagen and cuticulin-based cuticle extracellular matrix, a collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer." [GOC:dph] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: GO:0060102 + +[Term] +id: GO:0060104 +name: surface coat of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "surface coat of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060105 +name: epicuticle of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060106 +name: cortical layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060107 +name: annuli extracellular matrix +namespace: cellular_component +def: "The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "annulae" RELATED [] +synonym: "annular rings" RELATED [] +synonym: "annule(s)" RELATED [] +synonym: "annulus" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060108 +name: annular furrow extracellular matrix +namespace: cellular_component +def: "The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline." [GOC:dph, GOC:kmv, ISSN:15518507] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060106 ! cortical layer of collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060109 +name: medial layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "medial layer struts" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060110 +name: basal layer of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "basal layer of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060111 +name: alae of collagen and cuticulin-based cuticle extracellular matrix +namespace: cellular_component +def: "Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively." [GOC:dph, GOC:kmv, ISSN:15518507] +synonym: "alae of collagen and cuticulin-based exoskeleton extracellular matrix" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060102 ! collagen and cuticulin-based cuticle extracellular matrix + +[Term] +id: GO:0060112 +name: generation of ovulation cycle rhythm +namespace: biological_process +def: "The process which controls the timing of the type of sexual cycle seen in female mammals." [GOC:dph] +synonym: "generation of estrus cycle rhythm" EXACT [] +synonym: "generation of menstrual cycle rhythm" RELATED [] +synonym: "generation of oestrus cycle rhythm" EXACT [] +is_a: GO:0022602 ! ovulation cycle process + +[Term] +id: GO:0060113 +name: inner ear receptor cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound." [GOC:dph] +synonym: "inner ear hair cell differentiation" EXACT [] +is_a: GO:0042490 ! mechanoreceptor differentiation +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0060114 +name: vestibular receptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell." [GOC:dph] +synonym: "vestibular hair cell differentiation" EXACT [] +is_a: GO:0035315 ! hair cell differentiation +is_a: GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060115 +name: vestibular receptor cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become a vestibular receptor cell." [GOC:dph] +synonym: "vestibular hair cell fate commitment" EXACT [] +is_a: GO:0060120 ! inner ear receptor cell fate commitment +relationship: part_of GO:0060114 ! vestibular receptor cell differentiation + +[Term] +id: GO:0060116 +name: vestibular receptor cell morphogenesis +namespace: biological_process +def: "Any process that alters the size or shape of a vestibular receptor cell." [GOC:dph, GOC:tb] +synonym: "vestibular hair cell morphogenesis" EXACT [] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0060118 ! vestibular receptor cell development + +[Term] +id: GO:0060117 +name: auditory receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "auditory hair cell development" EXACT [] +is_a: GO:0060119 ! inner ear receptor cell development +relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation + +[Term] +id: GO:0060118 +name: vestibular receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "vestibular hair cell development" EXACT [] +is_a: GO:0060119 ! inner ear receptor cell development +relationship: part_of GO:0060114 ! vestibular receptor cell differentiation + +[Term] +id: GO:0060119 +name: inner ear receptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph] +synonym: "inner ear hair cell development" EXACT [] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060120 +name: inner ear receptor cell fate commitment +namespace: biological_process +def: "The process in which a cell becomes committed to become an inner ear receptor cell." [GOC:dph] +synonym: "inner ear hair cell fate commitment" EXACT [] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:0060121 +name: vestibular receptor cell stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells." [GOC:dph] +synonym: "vestibular hair cell stereocilium organization" EXACT [] +synonym: "vestibular receptor cell stereocilium organisation" EXACT [GOC:mah] +synonym: "vestibular receptor cell stereocilium organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0060122 ! inner ear receptor cell stereocilium organization +is_a: GO:0106027 ! neuron projection organization +relationship: part_of GO:0060116 ! vestibular receptor cell morphogenesis + +[Term] +id: GO:0060122 +name: inner ear receptor cell stereocilium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." [GOC:dph] +synonym: "inner ear hair cell receptor stereocilium organization" EXACT [] +synonym: "inner ear receptor stereocilium organisation" EXACT [GOC:mah] +synonym: "inner ear receptor stereocilium organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0031175 ! neuron projection development +relationship: part_of GO:0060119 ! inner ear receptor cell development + +[Term] +id: GO:0060123 +name: regulation of growth hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060124 +name: positive regulation of growth hormone secretion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] +is_a: GO:0060123 ! regulation of growth hormone secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060125 +name: negative regulation of growth hormone secretion +namespace: biological_process +def: "Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell." [GOC:dph] +is_a: GO:0060123 ! regulation of growth hormone secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0030252 ! growth hormone secretion + +[Term] +id: GO:0060126 +name: somatotropin secreting cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] +synonym: "growth hormone secreting cell differentiation" EXACT [] +synonym: "somatotrope differentiation" RELATED [] +synonym: "somatotroph differentiation" RELATED [] +synonym: "somatotrophin secreting cell differentiation" EXACT [] +synonym: "somatotropic cell differentiation" RELATED [] +synonym: "somatrophic cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060127 +name: prolactin secreting cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] +synonym: "epsilon-acidophil differentiation" EXACT [] +synonym: "lactotrope differentiation" EXACT [] +synonym: "lactotroph differentiation" EXACT [] +synonym: "lactotropic cell differentiation" EXACT [] +synonym: "mammotrope differentiation" EXACT [] +synonym: "mammotroph differentiation" EXACT [] +synonym: "mammotrophic cell differentiation" EXACT [] +synonym: "mammotropic cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060128 +name: corticotropin hormone secreting cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] +synonym: "adrenocorticotrophic hormone secreting cell differentiation" EXACT [] +synonym: "adrenocorticotropic hormone secreting cell differentiation" EXACT [GOC:dph] +synonym: "corticotrope differentiation" EXACT [] +synonym: "corticotroph differentiation" EXACT [] +synonym: "corticotrophin hormone secreting cell differentiation" RELATED [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060129 +name: thyroid-stimulating hormone-secreting cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin." [GOC:dph] +synonym: "beta-basophil differentiation" EXACT [] +synonym: "thyroid stimulating hormone secreting cell differentiation" EXACT [] +synonym: "thyrotrope differentiation" EXACT [] +synonym: "thyrotroph differentiation" EXACT [] +synonym: "TSH-secreting cell differentiation" EXACT [] +is_a: GO:0002067 ! glandular epithelial cell differentiation +is_a: GO:0061101 ! neuroendocrine cell differentiation +relationship: part_of GO:0021984 ! adenohypophysis development + +[Term] +id: GO:0060130 +name: thyroid-stimulating hormone-secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin." [GOC:dph] +synonym: "beta-basophil development" EXACT [] +synonym: "thyroid stimulating hormone secreting cell development" EXACT [] +synonym: "thyrotrope development" EXACT [] +synonym: "thyrotroph development" EXACT [] +synonym: "TSH-secreting cell development" EXACT [] +is_a: GO:0002068 ! glandular epithelial cell development +relationship: part_of GO:0060129 ! thyroid-stimulating hormone-secreting cell differentiation + +[Term] +id: GO:0060131 +name: corticotropin hormone secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." [GOC:dph] +synonym: "adrenocorticotrophic hormone secreting cell development" EXACT [] +synonym: "adrenocorticotropic hormone secreting cell development" EXACT [GOC:dph] +synonym: "corticotrope development" EXACT [] +synonym: "corticotroph development" RELATED [] +synonym: "corticotrophin hormone secreting cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060128 ! corticotropin hormone secreting cell differentiation + +[Term] +id: GO:0060132 +name: prolactin secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin." [GOC:dph] +synonym: "epsilon-acidophil development" EXACT [] +synonym: "lactotrope development" EXACT [] +synonym: "lactotroph development" EXACT [] +synonym: "lactotropic cell development" EXACT [] +synonym: "mammotrope development" EXACT [] +synonym: "mammotroph development" EXACT [] +synonym: "mammotrophic cell development" EXACT [] +synonym: "mammotropic cell development" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060127 ! prolactin secreting cell differentiation + +[Term] +id: GO:0060133 +name: somatotropin secreting cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin." [GOC:dph] +synonym: "growth hormone secreting cell development" EXACT [] +synonym: "somatotrope development" RELATED [] +synonym: "somatotroph development" RELATED [] +synonym: "somatotrophin secreting cell development" EXACT [] +synonym: "somatotropic cell development" EXACT [] +synonym: "somatrophic cell development" RELATED [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060126 ! somatotropin secreting cell differentiation + +[Term] +id: GO:0060134 +name: prepulse inhibition +namespace: biological_process +def: "The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse." [GOC:dph, PMID:10341260] +synonym: "PPI" RELATED [] +synonym: "pre-pulse inhibition" EXACT [] +xref: Wikipedia:Prepulse_inhibition +is_a: GO:0032102 ! negative regulation of response to external stimulus +relationship: part_of GO:0001964 ! startle response + +[Term] +id: GO:0060135 +name: maternal process involved in female pregnancy +namespace: biological_process +def: "A reproductive process occurring in the mother that allows an embryo or fetus to develop within it." [GOC:dph] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007565 ! female pregnancy + +[Term] +id: GO:0060136 +name: embryonic process involved in female pregnancy +namespace: biological_process +def: "A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother." [GOC:dph] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007565 ! female pregnancy +relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching + +[Term] +id: GO:0060137 +name: maternal process involved in parturition +namespace: biological_process +def: "A reproductive process occurring in the mother that results in birth." [GOC:dph] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007567 ! parturition + +[Term] +id: GO:0060138 +name: fetal process involved in parturition +namespace: biological_process +def: "A reproductive process occurring in the embryo that results in birth." [GOC:dph] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007567 ! parturition +relationship: part_of GO:0009792 ! embryo development ending in birth or egg hatching + +[Term] +id: GO:0060139 +name: positive regulation of apoptotic process by virus +namespace: biological_process +def: "Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:dph, GOC:mtg_apoptosis] +synonym: "positive regulation of apoptosis by virus" NARROW [] +is_a: GO:0039526 ! modulation by virus of host apoptotic process +is_a: GO:0052151 ! positive regulation by symbiont of host apoptotic process + +[Term] +id: GO:0060140 +name: modulation by virus of syncytium formation via plasma membrane fusion +namespace: biological_process +def: "The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: part_of GO:0006948 ! induction by virus of host cell-cell fusion + +[Term] +id: GO:0060141 +name: positive regulation of syncytium formation by virus +namespace: biological_process +def: "The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +synonym: "syncytium formation induced by viral infection" EXACT [UniProtKB-KW:KW-1180] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0060140 ! modulation by virus of syncytium formation via plasma membrane fusion +is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion + +[Term] +id: GO:0060142 +name: regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0060143 +name: positive regulation of syncytium formation by plasma membrane fusion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: positively_regulates GO:0000768 ! syncytium formation by plasma membrane fusion + +[Term] +id: GO:0060144 +name: obsolete host cellular process involved in virus induced gene silencing +namespace: biological_process +def: "OBSOLETE. A cellular process occurring in the host cell that contributes to the process of posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes." [GOC:dph] +comment: The reason for obsoletion is there there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0060146 +name: obsolete host gene silencing in virus induced gene silencing +namespace: biological_process +def: "OBSOLETE. The posttranscriptional gene silencing of host genes that are homologous to viral genes after viral infection." [GOC:dph] +comment: The reason for obsoletion is there there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0060147 +name: regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060148 +name: positive regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +relationship: positively_regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060149 +name: negative regulation of posttranscriptional gene silencing +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the inactivation of gene expression by a posttranscriptional mechanism." [GOC:dph] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +relationship: negatively_regulates GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0060151 +name: peroxisome localization +namespace: biological_process +def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] +synonym: "peroxisome localisation" EXACT [GOC:mah] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0060152 +name: microtubule-based peroxisome localization +namespace: biological_process +def: "The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] +synonym: "microtubule-based peroxisome localisation" EXACT [GOC:mah] +is_a: GO:0007017 ! microtubule-based process +is_a: GO:0060151 ! peroxisome localization + +[Term] +id: GO:0060153 +name: modulation by virus of host cell cycle +namespace: biological_process +def: "Any viral process that modulates the rate or extent of progression through the cell cycle." [GOC:dph, UniProtKB-KW:KW-1121, VZ:1636] +synonym: "modulation of host cell cycle by virus" EXACT [UniProtKB-KW:KW-1121] +synonym: "regulation by virus of host cell cycle" EXACT [] +synonym: "regulation of host cell cycle by virus" EXACT [] +synonym: "viral process regulating host cell cycle" EXACT [] +xref: VZ:1636 "Modulation of host cell cycle by virus" +is_a: GO:0019055 ! modification by virus of host cell cycle regulation + +[Term] +id: GO:0060154 +name: obsolete cellular process regulating host cell cycle in response to virus +namespace: biological_process +def: "OBSOLETE. Any cellular process that modulates the rate or extent of progression through the cell cycle in response to a virus." [GOC:dph] +comment: The reason for obsoletion is that based on the definition, it is not clear that this process exists. +is_obsolete: true + +[Term] +id: GO:0060155 +name: platelet dense granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:dph, PMID:11487378] +synonym: "bull's eye body organization and biogenesis" RELATED [] +synonym: "platelet dense body organization and biogenesis" RELATED [] +synonym: "platelet dense granule organisation" EXACT [GOC:mah] +synonym: "platelet dense granule organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0060156 +name: milk ejection reflex +namespace: biological_process +def: "A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness." [GOC:cjm, GOC:dph, GOC:mr, GOC:st] +synonym: "milk ejection" EXACT [] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0032941 ! secretion by tissue +is_a: GO:0060004 ! reflex +relationship: part_of GO:0007595 ! lactation + +[Term] +id: GO:0060157 +name: urinary bladder development +namespace: biological_process +def: "The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion." [GOC:dph, GOC:ln, GOC:mr, PMID:11768524, PMID:18276178, PMID:538956] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0060158 +name: phospholipase C-activating dopamine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:signaling, GOC:tb, PMID:12675914] +synonym: "activation of phospholipase C activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of phospholipase C activity by dopamine receptor signalling pathway" RELATED [GOC:mah] +synonym: "dopamine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060159 +name: regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a dopamine receptor signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060160 +name: negative regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopamine receptor protein signaling pathway activity. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "negative regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway +relationship: negatively_regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060161 +name: positive regulation of dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the dopamine receptor protein signaling pathway. A dopamine receptor signaling pathway is the series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "positive regulation of dopamine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway +relationship: positively_regulates GO:0007212 ! dopamine receptor signaling pathway + +[Term] +id: GO:0060162 +name: negative regulation of phospholipase C-activating dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway." [GOC:dph, GOC:tb, PMID:15016423] +synonym: "negative regulation of dopamine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] +synonym: "negative regulation of phospholipase C-activating dopamine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway +is_a: GO:1900737 ! negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +relationship: negatively_regulates GO:0060158 ! phospholipase C-activating dopamine receptor signaling pathway + +[Term] +id: GO:0060163 +name: subpallium neuron fate commitment +namespace: biological_process +def: "The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] +synonym: "subpallium neuronal precursor fate commitment" RELATED [] +is_a: GO:0048663 ! neuron fate commitment +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0060164 +name: regulation of timing of neuron differentiation +namespace: biological_process +def: "The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron." [GOC:dph] +is_a: GO:0045664 ! regulation of neuron differentiation +is_a: GO:0048505 ! regulation of timing of cell differentiation + +[Term] +id: GO:0060165 +name: regulation of timing of subpallium neuron differentiation +namespace: biological_process +def: "The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon." [GOC:dph] +is_a: GO:0060164 ! regulation of timing of neuron differentiation +relationship: part_of GO:0021544 ! subpallium development + +[Term] +id: GO:0060166 +name: olfactory pit development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx." [GOC:dph, ISBN:0124020607] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043584 ! nose development + +[Term] +id: GO:0060167 +name: regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway + +[Term] +id: GO:0060168 +name: positive regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "positive regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway +relationship: positively_regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway + +[Term] +id: GO:0060169 +name: negative regulation of adenosine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenosine receptor signaling pathway. The adenosine receptor pathway is the series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "negative regulation of adenosine receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0060167 ! regulation of adenosine receptor signaling pathway +relationship: negatively_regulates GO:0001973 ! G protein-coupled adenosine receptor signaling pathway + +[Term] +id: GO:0060170 +name: ciliary membrane +namespace: cellular_component +alt_id: GO:0020017 +def: "The portion of the plasma membrane surrounding a cilium." [GOC:cilia, GOC:dph, GOC:rph] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "cilial membrane" EXACT [] +synonym: "cilium membrane" EXACT [] +synonym: "flagellar membrane" NARROW [] +synonym: "flagellum membrane" NARROW [] +is_a: GO:0031253 ! cell projection membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0060171 +name: stereocilium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a stereocilium." [GOC:dph, GOC:rph] +is_a: GO:0032589 ! neuron projection membrane +relationship: part_of GO:0005622 ! intracellular anatomical structure +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0060172 +name: astral microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] +is_a: GO:0007019 ! microtubule depolymerization +is_a: GO:0030953 ! astral microtubule organization + +[Term] +id: GO:0060173 +name: limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin." [GOC:dgh, GOC:dph, PMID:11487378] +synonym: "limb bud development" NARROW [GOC:dph] +synonym: "paired limb/fin development" EXACT [] +xref: Wikipedia:Limb_development +is_a: GO:0048736 ! appendage development + +[Term] +id: GO:0060174 +name: limb bud formation +namespace: biological_process +def: "The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable." [GOC:dgh, GOC:dph] +synonym: "limb formation" EXACT [] +synonym: "limbbud formation" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035108 ! limb morphogenesis + +[Term] +id: GO:0060175 +name: brain-derived neurotrophic factor-activated receptor activity +namespace: molecular_function +def: "Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:dph] +comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand BDNF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. +synonym: "BDNF receptor activity" RELATED [GOC:dph] +synonym: "BDNF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] +synonym: "brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] +is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity +is_a: GO:0005030 ! neurotrophin receptor activity + +[Term] +id: GO:0060176 +name: regulation of aggregation involved in sorocarp development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0031152 ! aggregation involved in sorocarp development + +[Term] +id: GO:0060177 +name: regulation of angiotensin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin." [GOC:dph, GOC:tb] +synonym: "regulation of angiotensin metabolism" EXACT [] +is_a: GO:0051246 ! regulation of protein metabolic process + +[Term] +id: GO:0060178 +name: regulation of exocyst localization +namespace: biological_process +def: "Any process that modulates the localization of exocysts. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse." [GOC:dph, GOC:tb] +synonym: "regulation of exocyst localisation" EXACT [GOC:mah] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0051601 ! exocyst localization + +[Term] +id: GO:0060179 +name: male mating behavior +namespace: biological_process +def: "The specific behavior of a male organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0060180 +name: female mating behavior +namespace: biological_process +def: "The specific behavior of a female organism that is associated with reproduction." [GOC:dph, GOC:pr, GOC:tb] +is_a: GO:0007617 ! mating behavior + +[Term] +id: GO:0060182 +name: apelin receptor activity +namespace: molecular_function +def: "Combining with the peptide apelin to initiate a change in cell activity." [GOC:dph] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0060183 +name: apelin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands." [GOC:dph] +synonym: "apelin receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0060184 +name: cell cycle switching +namespace: biological_process +def: "The process in which a cell switches cell cycle mode." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0060185 +name: outer ear unfolding +namespace: biological_process +def: "The opening and spreading out of the outer ear." [GOC:dph] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0042473 ! outer ear morphogenesis + +[Term] +id: GO:0060186 +name: outer ear emergence +namespace: biological_process +def: "The growth of the outer ear." [GOC:dph] +synonym: "ear elevation" RELATED [GOC:dph] +synonym: "ear extroversion" RELATED [GOC:dph] +synonym: "outer ear growth" RELATED [GOC:dph] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0042473 ! outer ear morphogenesis + +[Term] +id: GO:0060187 +name: cell pole +namespace: cellular_component +def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] +comment: Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal. +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0060188 +name: regulation of protein desumoylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060189 +name: positive regulation of protein desumoylation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0060188 ! regulation of protein desumoylation +is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal +relationship: positively_regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060190 +name: negative regulation of protein desumoylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:dph, GOC:tb] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0060188 ! regulation of protein desumoylation +is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal +relationship: negatively_regulates GO:0016926 ! protein desumoylation + +[Term] +id: GO:0060191 +name: regulation of lipase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0060192 +name: negative regulation of lipase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:dph, GOC:tb] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0060193 +name: positive regulation of lipase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0060191 ! regulation of lipase activity + +[Term] +id: GO:0060194 +name: regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:jp, GOC:tb, PMID:18075583] +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060195 +name: negative regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0060194 ! regulation of antisense RNA transcription +relationship: negatively_regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060196 +name: positive regulation of antisense RNA transcription +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:dph, GOC:tb, PMID:18075583] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:0060194 ! regulation of antisense RNA transcription +relationship: positively_regulates GO:0009300 ! antisense RNA transcription + +[Term] +id: GO:0060197 +name: cloacal septation +namespace: biological_process +def: "The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development." [GOC:dph, GOC:st] +synonym: "cloaca septation" EXACT [GOC:cjm] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0035844 ! cloaca development + +[Term] +id: GO:0060198 +name: clathrin-sculpted vesicle +namespace: cellular_component +def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release." [GOC:dph] +synonym: "clathrin sculpted vesicle" EXACT [GOC:sl] +is_a: GO:0030136 ! clathrin-coated vesicle + +[Term] +id: GO:0060199 +name: clathrin-sculpted glutamate transport vesicle +namespace: cellular_component +def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate." [GOC:dph] +synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle" EXACT [] +synonym: "clathrin sculpted glutamate transport vesicle" EXACT [GOC:sl] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin-sculpted vesicle + +[Term] +id: GO:0060200 +name: clathrin-sculpted acetylcholine transport vesicle +namespace: cellular_component +def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine." [GOC:dph] +synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle" EXACT [] +synonym: "clathrin sculpted acetylcholine transport vesicle" EXACT [GOC:sl] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin-sculpted vesicle + +[Term] +id: GO:0060201 +name: clathrin-sculpted acetylcholine transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle." [GOC:dph] +synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "clathrin sculpted acetylcholine transport vesicle membrane" EXACT [GOC:sl] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin-coated vesicle membrane +relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle + +[Term] +id: GO:0060202 +name: clathrin-sculpted acetylcholine transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle." [GOC:dph] +synonym: "clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen" EXACT [] +synonym: "clathrin sculpted acetylcholine transport vesicle lumen" EXACT [GOC:sl] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0060200 ! clathrin-sculpted acetylcholine transport vesicle + +[Term] +id: GO:0060203 +name: clathrin-sculpted glutamate transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle." [GOC:dph] +synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "clathrin sculpted glutamate transport vesicle membrane" EXACT [GOC:sl] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin-coated vesicle membrane +relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle + +[Term] +id: GO:0060204 +name: clathrin-sculpted glutamate transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle." [GOC:dph] +synonym: "clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen" EXACT [] +synonym: "clathrin sculpted glutamate transport vesicle lumen" EXACT [GOC:sl] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0060199 ! clathrin-sculpted glutamate transport vesicle + +[Term] +id: GO:0060205 +name: cytoplasmic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by a cytoplasmic vesicle." [GOC:dph, GOC:vesicles] +synonym: "cytoplasmic membrane-bounded vesicle lumen" RELATED [] +synonym: "cytoplasmic membrane-enclosed vesicle lumen" RELATED [] +is_a: GO:0031983 ! vesicle lumen +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0060206 +name: estrous cycle phase +namespace: biological_process +def: "The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur." [GOC:dph] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0044848 ! biological phase + +[Term] +id: GO:0060207 +name: diestrus +namespace: biological_process +def: "The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum." [GOC:dph, ISBN:0721662544] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060208 +name: proestrus +namespace: biological_process +def: "The estrous cycle phase in which there is heightened follicular activity." [GOC:dph, ISBN:0721662544] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060209 +name: estrus +namespace: biological_process +def: "The estrous cycle phase in which a female is sexually receptive." [GOC:dph, ISBN:0721662544] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "oestrus" EXACT [] +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060210 +name: metestrus +namespace: biological_process +def: "The estrous cycle phase in which there is subsiding follicular function." [GOC:dph, ISBN:0721662544] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0060206 ! estrous cycle phase + +[Term] +id: GO:0060211 +name: regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "regulation of 3' to 5' mRNA deadenylation" RELATED [] +synonym: "regulation of mRNA deadenylation" RELATED [] +synonym: "regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0061013 ! regulation of mRNA catabolic process +relationship: regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060212 +name: negative regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "negative regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening +is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +relationship: negatively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060213 +name: positive regulation of nuclear-transcribed mRNA poly(A) tail shortening +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length." [GOC:dph, GOC:tb] +synonym: "positive regulation of 3' to 5' mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of mRNA deadenylation" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of nuclear mRNA poly(A) tail shortening" RELATED [] +is_a: GO:0060211 ! regulation of nuclear-transcribed mRNA poly(A) tail shortening +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +relationship: positively_regulates GO:0000289 ! nuclear-transcribed mRNA poly(A) tail shortening + +[Term] +id: GO:0060214 +name: endocardium formation +namespace: biological_process +def: "Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:bf, GOC:dph, PMID:17722983] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0003160 ! endocardium morphogenesis + +[Term] +id: GO:0060215 +name: primitive hemopoiesis +namespace: biological_process +def: "A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] +synonym: "primitive haematopoiesis" EXACT [] +synonym: "primitive haemopoiesis" EXACT [] +synonym: "primitive hematopoiesis" RELATED [] +is_a: GO:0035162 ! embryonic hemopoiesis + +[Term] +id: GO:0060216 +name: definitive hemopoiesis +namespace: biological_process +def: "A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood." [GOC:bf, GOC:dph, PMID:15378083, PMID:15617691] +synonym: "definitive haematopoiesis" RELATED [] +synonym: "definitive haemopoiesis" EXACT [] +synonym: "definitive hematopoiesis" EXACT [] +is_a: GO:0030097 ! hemopoiesis + +[Term] +id: GO:0060217 +name: hemangioblast cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages." [GOC:bf, GOC:dph, PMID:15378083, PMID:9670018] +is_a: GO:0048333 ! mesodermal cell differentiation +relationship: part_of GO:0060215 ! primitive hemopoiesis + +[Term] +id: GO:0060218 +name: hematopoietic stem cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:bf, GOC:BHF, GOC:dph, GOC:rl, PMID:15378083] +synonym: "haematopoietic stem cell differentiation" EXACT [] +synonym: "haemopoietic stem cell differentiation" EXACT [] +synonym: "hemopoietic stem cell differentiation" EXACT [] +is_a: GO:0002244 ! hematopoietic progenitor cell differentiation +is_a: GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0060219 +name: camera-type eye photoreceptor cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0001754 ! eye photoreceptor cell differentiation +relationship: part_of GO:0003407 ! neural retina development +relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye + +[Term] +id: GO:0060220 +name: camera-type eye photoreceptor cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye." [GOC:dph] +is_a: GO:0042706 ! eye photoreceptor cell fate commitment +relationship: part_of GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0060221 +name: retinal rod cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell." [GOC:dph] +is_a: GO:0060219 ! camera-type eye photoreceptor cell differentiation + +[Term] +id: GO:0060222 +name: regulation of retinal cone cell fate commitment +namespace: biological_process +def: "Any process that modulates the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] +is_a: GO:0010453 ! regulation of cell fate commitment +relationship: regulates GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0060223 +name: retinal rod cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0060220 ! camera-type eye photoreceptor cell fate commitment +relationship: part_of GO:0060221 ! retinal rod cell differentiation + +[Term] +id: GO:0060224 +name: regulation of retinal rod cell fate commitment +namespace: biological_process +def: "Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0060223 ! retinal rod cell fate commitment + +[Term] +id: GO:0060225 +name: positive regulation of retinal rod cell fate commitment +namespace: biological_process +def: "Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye." [GOC:dph] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +is_a: GO:0060224 ! regulation of retinal rod cell fate commitment +relationship: positively_regulates GO:0060223 ! retinal rod cell fate commitment + +[Term] +id: GO:0060226 +name: negative regulation of retinal cone cell fate commitment +namespace: biological_process +def: "Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell." [GOC:dph] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation +is_a: GO:0060222 ! regulation of retinal cone cell fate commitment +relationship: negatively_regulates GO:0046551 ! retinal cone cell fate commitment + +[Term] +id: GO:0060227 +name: Notch signaling pathway involved in camera-type eye photoreceptor fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a precursor cell to a eye photoreceptor fate." [GOC:dph] +synonym: "Notch signalling pathway involved in camera-type eye photoreceptor fate commitment" EXACT [GOC:mah] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0060220 ! camera-type eye photoreceptor cell fate commitment + +[Term] +id: GO:0060228 +name: phosphatidylcholine-sterol O-acyltransferase activator activity +namespace: molecular_function +def: "Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines." [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615] +synonym: "LCAT activator activity" NARROW [GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0060229 +name: lipase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0060230 +name: lipoprotein lipase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein." [GOC:BHF, GOC:dph, GOC:tb, PMID:10727238] +is_a: GO:0060229 ! lipase activator activity + +[Term] +id: GO:0060231 +name: mesenchymal to epithelial transition +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "epithelial cell differentiation from mesenchymal cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] +synonym: "mesenchymal-epithelial transition" EXACT [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0060232 +name: delamination +namespace: biological_process +def: "The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet." [GOC:dph, PMID:16962574, PMID:18343170] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion + +[Term] +id: GO:0060233 +name: oenocyte delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet." [GOC:dph] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0060234 +name: neuroblast delamination +namespace: biological_process +def: "The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet." [GOC:dph] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0060235 +name: lens induction in camera-type eye +namespace: biological_process +def: "Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens." [GOC:dph, ISBN:0878932437] +is_a: GO:0031128 ! developmental induction +relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye + +[Term] +id: GO:0060236 +name: regulation of mitotic spindle organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of mitotic spindle organisation" EXACT [GOC:mah] +synonym: "regulation of mitotic spindle organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0090224 ! regulation of spindle organization +relationship: regulates GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0060237 +name: regulation of fungal-type cell wall organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:tb] +synonym: "regulation of fungal-type cell wall organisation" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall organization and biogenesis" RELATED [] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: regulates GO:0031505 ! fungal-type cell wall organization + +[Term] +id: GO:0060238 +name: regulation of signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +relationship: regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0060239 +name: positive regulation of signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion +is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion +relationship: positively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0060240 +name: negative regulation of signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion + +[Term] +id: GO:0060241 +name: lysozyme inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of lysozyme." [GOC:dph] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0060242 +name: contact inhibition +namespace: biological_process +alt_id: GO:0060246 +alt_id: GO:0060248 +def: "The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation." [GOC:dph, PMID:17376520] +synonym: "detection of cell density by contact stimulus" RELATED [] +synonym: "detection of cell density by contact stimulus involved in contact inhibition" RELATED [] +xref: Wikipedia:Contact_inhibition +is_a: GO:0060245 ! detection of cell density + +[Term] +id: GO:0060243 +name: negative regulation of cell growth involved in contact inhibition +namespace: biological_process +def: "The negative regulation of cell growth in response to increased cell density." [GOC:dph] +is_a: GO:0030308 ! negative regulation of cell growth +relationship: part_of GO:0060242 ! contact inhibition + +[Term] +id: GO:0060244 +name: negative regulation of cell proliferation involved in contact inhibition +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density." [GOC:dph] +is_a: GO:0008285 ! negative regulation of cell population proliferation +relationship: part_of GO:0060242 ! contact inhibition + +[Term] +id: GO:0060245 +name: detection of cell density +namespace: biological_process +def: "The series of events in which information about the density of cells in a population is received and converted into a molecular signal." [GOC:dph] +is_a: GO:0009595 ! detection of biotic stimulus + +[Term] +id: GO:0060249 +name: anatomical structure homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] +synonym: "anatomical structure maintenance" EXACT [GOC:dph] +is_a: GO:0042592 ! homeostatic process + +[Term] +id: GO:0060250 +name: germ-line stem-cell niche homeostasis +namespace: biological_process +def: "A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion." [GOC:dph] +synonym: "germ-line stem-cell niche maintenance" EXACT [GOC:dph, GOC:tb] +synonym: "maintenance of germ line stem cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ line stem-cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ-line stem cell niche" EXACT [GOC:dph] +synonym: "maintenance of germ-line stem-cell niche" EXACT [GOC:dph] +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0060251 +name: regulation of glial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glial cell proliferation." [GOC:dph, GOC:tb] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060252 +name: positive regulation of glial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0014015 ! positive regulation of gliogenesis +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: positively_regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060253 +name: negative regulation of glial cell proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of glial cell proliferation." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0014014 ! negative regulation of gliogenesis +is_a: GO:0060251 ! regulation of glial cell proliferation +relationship: negatively_regulates GO:0014009 ! glial cell proliferation + +[Term] +id: GO:0060254 +name: regulation of N-terminal protein palmitoylation +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] +is_a: GO:1903059 ! regulation of protein lipidation +relationship: regulates GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0060255 +name: regulation of macromolecule metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0060256 +name: regulation of flocculation +namespace: biological_process +alt_id: GO:1900455 +def: "Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [PMID:10591965, PMID:15466424, PMID:16568252] +synonym: "regulation of flocculation via cell wall protein-carbohydrate interaction" RELATED [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0000128 ! flocculation + +[Term] +id: GO:0060257 +name: negative regulation of flocculation +namespace: biological_process +alt_id: GO:1901134 +def: "Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms." [GOC:dph, GOC:tb] +synonym: "negative regulation of coflocculation" NARROW [] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0060256 ! regulation of flocculation +relationship: negatively_regulates GO:0000128 ! flocculation + +[Term] +id: GO:0060258 +name: negative regulation of filamentous growth +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] +is_a: GO:0010570 ! regulation of filamentous growth +is_a: GO:0045926 ! negative regulation of growth +relationship: negatively_regulates GO:0030447 ! filamentous growth + +[Term] +id: GO:0060259 +name: regulation of feeding behavior +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of feeding behaviour" EXACT [GOC:dph, GOC:tb] +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0007631 ! feeding behavior + +[Term] +id: GO:0060260 +name: regulation of transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation +relationship: regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0060261 +name: positive regulation of transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter +is_a: GO:2000144 ! positive regulation of DNA-templated transcription, initiation +relationship: positively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0060262 +name: negative regulation of N-terminal protein palmitoylation +namespace: biological_process +def: "Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:dph, GOC:tb] +is_a: GO:0060254 ! regulation of N-terminal protein palmitoylation +is_a: GO:1903060 ! negative regulation of protein lipidation +relationship: negatively_regulates GO:0006500 ! N-terminal protein palmitoylation + +[Term] +id: GO:0060263 +name: regulation of respiratory burst +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060264 +name: regulation of respiratory burst involved in inflammatory response +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +synonym: "regulation of respiratory burst involved in acute inflammatory response" BROAD [] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060263 ! regulation of respiratory burst +relationship: regulates GO:0002536 ! respiratory burst involved in inflammatory response + +[Term] +id: GO:0060265 +name: positive regulation of respiratory burst involved in inflammatory response +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of respiratory burst involved in acute inflammatory response" BROAD [] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response +is_a: GO:0060267 ! positive regulation of respiratory burst +relationship: positively_regulates GO:0002536 ! respiratory burst involved in inflammatory response + +[Term] +id: GO:0060266 +name: negative regulation of respiratory burst involved in inflammatory response +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of respiratory burst involved in acute inflammatory response" BROAD [] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060264 ! regulation of respiratory burst involved in inflammatory response +is_a: GO:0060268 ! negative regulation of respiratory burst +is_a: GO:0060284 ! regulation of cell development +relationship: negatively_regulates GO:0002536 ! respiratory burst involved in inflammatory response + +[Term] +id: GO:0060267 +name: positive regulation of respiratory burst +namespace: biological_process +def: "Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0060263 ! regulation of respiratory burst +relationship: positively_regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060268 +name: negative regulation of respiratory burst +namespace: biological_process +def: "Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:dph, GOC:tb] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0060263 ! regulation of respiratory burst +relationship: negatively_regulates GO:0045730 ! respiratory burst + +[Term] +id: GO:0060269 +name: centripetally migrating follicle cell migration +namespace: biological_process +def: "The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte." [GOC:dph] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0060270 +name: main body follicle cell migration +namespace: biological_process +def: "The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte." [GOC:dph] +is_a: GO:0007297 ! ovarian follicle cell migration + +[Term] +id: GO:0060271 +name: cilium assembly +namespace: biological_process +alt_id: GO:0042384 +def: "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:BHF, GOC:cilia, GOC:dph, GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732, PMID:13978319, PMID:27350441, Reactome:R-HSA-5617833.2] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "ciliogenesis" EXACT [] +synonym: "cilium biogenesis" RELATED [GOC:mah] +synonym: "cilium formation" EXACT [] +synonym: "cilium morphogenesis" RELATED [] +synonym: "cilium organization" RELATED [GOC:dph] +synonym: "microtubule-based flagellum assembly" EXACT [] +xref: Reactome:R-HSA-5617833.2 +is_a: GO:0044782 ! cilium organization +is_a: GO:0070925 ! organelle assembly +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0060272 +name: embryonic skeletal joint morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton." [GOC:bf, GOC:BHF, GOC:dph, UBERON:0000982] +is_a: GO:0048704 ! embryonic skeletal system morphogenesis +relationship: part_of GO:0072498 ! embryonic skeletal joint development + +[Term] +id: GO:0060273 +name: crying behavior +namespace: biological_process +def: "The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli." [GOC:dph] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0060274 +name: maintenance of stationary phase +namespace: biological_process +def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph] +is_a: GO:0044764 ! multi-organism cellular process + +[Term] +id: GO:0060275 +name: maintenance of stationary phase in response to starvation +namespace: biological_process +def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment." [GOC:dph] +is_a: GO:0042594 ! response to starvation +is_a: GO:0060274 ! maintenance of stationary phase + +[Term] +id: GO:0060276 +name: maintenance of stationary phase in response to toxin +namespace: biological_process +def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment." [GOC:dph] +is_a: GO:0060274 ! maintenance of stationary phase +relationship: part_of GO:0009636 ! response to toxic substance + +[Term] +id: GO:0060277 +name: obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stop, prevents or decreases transcription as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. +synonym: "negative regulation of transcription from RNA polymerase II promoter during G1 phase of mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0071930 + +[Term] +id: GO:0060278 +name: regulation of ovulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060279 +name: positive regulation of ovulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060278 ! regulation of ovulation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060280 +name: negative regulation of ovulation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060278 ! regulation of ovulation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0030728 ! ovulation + +[Term] +id: GO:0060281 +name: regulation of oocyte development +namespace: biological_process +def: "Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb, PMID:2394318] +is_a: GO:1905879 ! regulation of oogenesis +relationship: regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060282 +name: positive regulation of oocyte development +namespace: biological_process +def: "Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060283 +name: negative regulation of oocyte development +namespace: biological_process +def: "Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dph, GOC:tb] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0060281 ! regulation of oocyte development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048599 ! oocyte development + +[Term] +id: GO:0060284 +name: regulation of cell development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:dph, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0048468 ! cell development + +[Term] +id: GO:0060285 +name: cilium-dependent cell motility +namespace: biological_process +alt_id: GO:0071974 +def: "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, GOC:mtg_cambridge_2013] +comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. +synonym: "ciliary cell motility" RELATED [] +synonym: "cilium cell motility" EXACT [] +synonym: "microtubule-based flagellar cell motility" EXACT [] +is_a: GO:0001539 ! cilium or flagellum-dependent cell motility + +[Term] +id: GO:0060286 +name: obsolete flagellar cell motility +namespace: biological_process +def: "OBSOLETE. Cell motility due to the motion of one or more flagella." [GOC:dgh, GOC:dph, GOC:mlg] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "flagellar cell motility" EXACT [] +is_obsolete: true +consider: GO:0060285 +consider: GO:0071973 + +[Term] +id: GO:0060287 +name: epithelial cilium movement involved in determination of left/right asymmetry +namespace: biological_process +def: "The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves." [GOC:dgh, GOC:dph, GOC:krc, GOC:mlg, PMID:28559696, PMID:29367579] +synonym: "cilium movement involved in determinationof L/R asymmetry" EXACT [] +synonym: "Kuppfer's vesicle cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia] +synonym: "nodal cilium movement involved in determination of left/right asymmetry" NARROW [GOC:cilia] +is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0060288 +name: formation of a compartment boundary +namespace: biological_process +def: "Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] +synonym: "compartment boundary formation" EXACT [] +is_a: GO:0048859 ! formation of anatomical boundary +relationship: part_of GO:0007386 ! compartment pattern specification + +[Term] +id: GO:0060289 +name: compartment boundary maintenance +namespace: biological_process +def: "A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier." [GOC:dph] +is_a: GO:0001894 ! tissue homeostasis +relationship: part_of GO:0007386 ! compartment pattern specification + +[Term] +id: GO:0060290 +name: transdifferentiation +namespace: biological_process +def: "The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate." [GOC:dph, GOC:kmv] +xref: Wikipedia:Transdifferentiation +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0060291 +name: long-term synaptic potentiation +namespace: biological_process +def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] +synonym: "long-term potentiation" BROAD [GOC:dph] +synonym: "LTP" RELATED [GOC:dph] +is_a: GO:0048167 ! regulation of synaptic plasticity +is_a: GO:0050806 ! positive regulation of synaptic transmission + +[Term] +id: GO:0060292 +name: long-term synaptic depression +namespace: biological_process +def: "A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse." [GOC:dgh, GOC:dph] +synonym: "long term depression" BROAD [GOC:dph] +synonym: "long term synaptic depression" EXACT [] +synonym: "LTD" RELATED [GOC:dph] +is_a: GO:0048167 ! regulation of synaptic plasticity +is_a: GO:0050805 ! negative regulation of synaptic transmission + +[Term] +id: GO:0060293 +name: germ plasm +namespace: cellular_component +def: "Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line." [GOC:dph] +xref: Wikipedia:Germ_plasm +is_a: GO:0045495 ! pole plasm + +[Term] +id: GO:0060294 +name: cilium movement involved in cell motility +namespace: biological_process +def: "Movement of cilia mediated by motor proteins that contributes to the movement of a cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0003341 ! cilium movement +relationship: part_of GO:0060285 ! cilium-dependent cell motility + +[Term] +id: GO:0060295 +name: regulation of cilium movement involved in cell motility +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0003352 ! regulation of cilium movement +is_a: GO:1902019 ! regulation of cilium-dependent cell motility +relationship: regulates GO:0060294 ! cilium movement involved in cell motility + +[Term] +id: GO:0060296 +name: regulation of cilium beat frequency involved in ciliary motility +namespace: biological_process +def: "Any process that modulates the frequency of cilium beating involved in ciliary motility." [GOC:BHF, GOC:cilia, GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0003356 ! regulation of cilium beat frequency +is_a: GO:0060295 ! regulation of cilium movement involved in cell motility +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0060297 +name: regulation of sarcomere organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of sarcomere organisation" EXACT [GOC:mah] +is_a: GO:0110020 ! regulation of actomyosin structure organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060298 +name: positive regulation of sarcomere organization +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of sarcomere organisation" EXACT [GOC:mah] +is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0060297 ! regulation of sarcomere organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060299 +name: negative regulation of sarcomere organization +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of sarcomere organisation" EXACT [GOC:mah] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0060297 ! regulation of sarcomere organization +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0045214 ! sarcomere organization + +[Term] +id: GO:0060300 +name: regulation of cytokine activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:0060301 +name: positive regulation of cytokine activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0060300 ! regulation of cytokine activity +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0060302 +name: negative regulation of cytokine activity +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060300 ! regulation of cytokine activity +is_a: GO:1900121 ! negative regulation of receptor binding + +[Term] +id: GO:0060303 +name: regulation of nucleosome density +namespace: biological_process +def: "Any process that modulates the number of nucleosomes in a given region of a chromosome." [GOC:dph, GOC:tb] +is_a: GO:0034728 ! nucleosome organization +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0060304 +name: regulation of phosphatidylinositol dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol." [GOC:dph, GOC:tb] +synonym: "regulation of phosphoinositide dephosphorylation" EXACT [] +is_a: GO:0035303 ! regulation of dephosphorylation +is_a: GO:0060255 ! regulation of macromolecule metabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0046856 ! phosphatidylinositol dephosphorylation + +[Term] +id: GO:0060305 +name: regulation of cell diameter +namespace: biological_process +def: "Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell." [GOC:dph, GOC:tb] +synonym: "regulation of cell width" BROAD [GOC:dph, GOC:tb] +is_a: GO:0008361 ! regulation of cell size + +[Term] +id: GO:0060306 +name: regulation of membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0042391 ! regulation of membrane potential +relationship: regulates GO:0086009 ! membrane repolarization + +[Term] +id: GO:0060307 +name: regulation of ventricular cardiac muscle cell membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiomyocyte membrane repolarization" EXACT [] +synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization +relationship: regulates GO:0099625 ! ventricular cardiac muscle cell membrane repolarization + +[Term] +id: GO:0060308 +name: GTP cyclohydrolase I regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0060309 +name: elastin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "elastin breakdown" EXACT [] +synonym: "elastin catabolism" EXACT [] +synonym: "elastin degradation" EXACT [] +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0051541 ! elastin metabolic process + +[Term] +id: GO:0060310 +name: regulation of elastin catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of elastin breakdown" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of elastin catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of elastin degradation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:1903018 ! regulation of glycoprotein metabolic process +relationship: regulates GO:0060309 ! elastin catabolic process + +[Term] +id: GO:0060311 +name: negative regulation of elastin catabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "down-regulation of elastin catabolic process" EXACT [] +synonym: "negative regulation of elastin breakdown" EXACT [] +synonym: "negative regulation of elastin catabolism" EXACT [] +synonym: "negative regulation of elastin degradation" EXACT [] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:0060310 ! regulation of elastin catabolic process +is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process +relationship: negatively_regulates GO:0060309 ! elastin catabolic process + +[Term] +id: GO:0060312 +name: regulation of blood vessel remodeling +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:0060313 +name: negative regulation of blood vessel remodeling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "down-regulation of blood vessel remodeling" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of blood vessel remodeling" NARROW [GOC:dph, GOC:tb] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0060312 ! regulation of blood vessel remodeling +relationship: negatively_regulates GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:0060314 +name: regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:0060315 +name: negative regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol +is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:0060316 +name: positive regulation of ryanodine-sensitive calcium-release channel activity +namespace: biological_process +def: "Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol +is_a: GO:0060314 ! regulation of ryanodine-sensitive calcium-release channel activity +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:0060317 +name: cardiac epithelial to mesenchymal transition +namespace: biological_process +def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, PMID:16314491, PMID:1996351] +synonym: "heart epithelial to mesenchymal transition" EXACT [] +is_a: GO:0001837 ! epithelial to mesenchymal transition +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0060318 +name: definitive erythrocyte differentiation +namespace: biological_process +def: "Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] +synonym: "definitive erythropoiesis" EXACT [] +synonym: "definitive RBC differentiation" EXACT [CL:0000232] +synonym: "definitive red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0030218 ! erythrocyte differentiation +relationship: part_of GO:0060216 ! definitive hemopoiesis + +[Term] +id: GO:0060319 +name: primitive erythrocyte differentiation +namespace: biological_process +def: "Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:BHF, GOC:dph] +synonym: "primitive erythropoiesis" EXACT [GOC:add, GOC:dph] +synonym: "primitive RBC differentiation" EXACT [CL:0000232] +synonym: "primitive red blood cell differentiation" EXACT [CL:0000232] +is_a: GO:0030218 ! erythrocyte differentiation +relationship: part_of GO:0060215 ! primitive hemopoiesis + +[Term] +id: GO:0060320 +name: rejection of self pollen +namespace: biological_process +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma." [GOC:dph, GOC:tb] +is_a: GO:0048544 ! recognition of pollen + +[Term] +id: GO:0060321 +name: acceptance of pollen +namespace: biological_process +def: "The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma." [GOC:dph, GOC:tb] +synonym: "acceptance of non-self pollen" RELATED [GOC:dph, GOC:tb] +synonym: "acceptance of self pollen" NARROW [GOC:dph, GOC:tb] +is_a: GO:0048544 ! recognition of pollen + +[Term] +id: GO:0060322 +name: head development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0060323 +name: head morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0010171 ! body morphogenesis +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0060324 +name: face development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060322 ! head development + +[Term] +id: GO:0060325 +name: face morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060323 ! head morphogenesis +relationship: part_of GO:0060324 ! face development + +[Term] +id: GO:0060326 +name: cell chemotaxis +namespace: biological_process +def: "The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] +is_a: GO:0006935 ! chemotaxis +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0060327 +name: cytoplasmic actin-based contraction involved in cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another." [GOC:dph] +is_a: GO:0070252 ! actin-mediated cell contraction +relationship: part_of GO:0048870 ! cell motility + +[Term] +id: GO:0060328 +name: cytoplasmic actin-based contraction involved in forward cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell." [GOC:dph] +synonym: "cytoplasmic actin-based contraction involved in forward cell locomotion" RELATED [] +is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility + +[Term] +id: GO:0060329 +name: cytoplasmic actin-based contraction involved in rearward cell motility +namespace: biological_process +def: "The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell." [GOC:dph] +synonym: "cytoplasmic actin-based contraction involved in rearward cell locomotion" RELATED [] +is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility + +[Term] +id: GO:0060330 +name: regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "regulation of response to gamma-interferon" RELATED [] +synonym: "regulation of response to immune interferon" EXACT [] +synonym: "regulation of response to type II IFN" BROAD [] +synonym: "regulation of response to type II interferon" BROAD [] +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0060759 ! regulation of response to cytokine stimulus +relationship: regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060331 +name: negative regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "negative regulation of response to gamma-interferon" RELATED [] +synonym: "negative regulation of response to immune interferon" EXACT [] +synonym: "negative regulation of response to type II IFN" BROAD [] +synonym: "negative regulation of response to type II interferon" BROAD [] +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0060330 ! regulation of response to interferon-gamma +is_a: GO:0060761 ! negative regulation of response to cytokine stimulus +relationship: negatively_regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060332 +name: positive regulation of response to interferon-gamma +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus." [GOC:dph] +synonym: "positive regulation of response to gamma-interferon" RELATED [] +synonym: "positive regulation of response to immune interferon" EXACT [] +synonym: "positive regulation of response to type II IFN" BROAD [] +synonym: "positive regulation of response to type II interferon" BROAD [] +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0060330 ! regulation of response to interferon-gamma +is_a: GO:0060760 ! positive regulation of response to cytokine stimulus +relationship: positively_regulates GO:0034341 ! response to interferon-gamma + +[Term] +id: GO:0060333 +name: interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:dph, GOC:signaling] +synonym: "gamma-interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "immune interferon signaling pathway" EXACT [GOC:dph] +synonym: "interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] +synonym: "type II IFN-mediated signaling pathway" BROAD [] +synonym: "type II interferon-mediated signaling pathway" BROAD [GOC:dph] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071346 ! cellular response to interferon-gamma + +[Term] +id: GO:0060334 +name: regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "regulation of immune interferon signaling pathway" EXACT [GOC:dph] +synonym: "regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] +synonym: "regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph] +synonym: "regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +is_a: GO:0060330 ! regulation of response to interferon-gamma +relationship: regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060335 +name: positive regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "positive regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "positive regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "positive regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of type II IFN-mediated pathway" BROAD [GOC:dph] +synonym: "positive regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0060332 ! positive regulation of response to interferon-gamma +is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway +relationship: positively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060336 +name: negative regulation of interferon-gamma-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor." [GOC:dph] +synonym: "negative regulation of gamma-interferon-mediated signaling pathway" RELATED [GOC:dph] +synonym: "negative regulation of immune interferon-mediated signaling pathway" EXACT [GOC:dph] +synonym: "negative regulation of interferon-gamma-mediated signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of type II IFN-mediated signaling pathway" BROAD [GOC:dph] +synonym: "negative regulation of type II interferon-mediated signaling pathway" BROAD [GOC:dph] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0060331 ! negative regulation of response to interferon-gamma +is_a: GO:0060334 ! regulation of interferon-gamma-mediated signaling pathway +relationship: negatively_regulates GO:0060333 ! interferon-gamma-mediated signaling pathway + +[Term] +id: GO:0060337 +name: type I interferon signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:dph, GOC:signaling] +synonym: "type I interferon-activated signaling pathway" EXACT [GOC:signaling] +synonym: "type I interferon-mediated signaling pathway" RELATED [GOC:signaling] +synonym: "type I interferon-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071357 ! cellular response to type I interferon + +[Term] +id: GO:0060338 +name: regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +synonym: "regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0060337 ! type I interferon signaling pathway + +[Term] +id: GO:0060339 +name: negative regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +synonym: "negative regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway +relationship: negatively_regulates GO:0060337 ! type I interferon signaling pathway + +[Term] +id: GO:0060340 +name: positive regulation of type I interferon-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor." [GOC:dph] +synonym: "positive regulation of type I interferon-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0060338 ! regulation of type I interferon-mediated signaling pathway +relationship: positively_regulates GO:0060337 ! type I interferon signaling pathway + +[Term] +id: GO:0060341 +name: regulation of cellular localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell." [GOC:dph, GOC:tb] +synonym: "regulation of cellular localisation" EXACT [GOC:mah] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0051641 ! cellular localization + +[Term] +id: GO:0060342 +name: photoreceptor inner segment membrane +namespace: cellular_component +def: "The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:dph] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0001917 ! photoreceptor inner segment + +[Term] +id: GO:0060343 +name: trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] +synonym: "trabecula biogenesis" RELATED [GOC:dph] +synonym: "trabeculation" EXACT [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0061383 ! trabecula morphogenesis + +[Term] +id: GO:0060344 +name: liver trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "liver trabecula biogenesis" RELATED [] +synonym: "liver trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0060345 +name: spleen trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "spleen trabecula biogenesis" RELATED [GOC:dph] +synonym: "spleen trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0048536 ! spleen development + +[Term] +id: GO:0060346 +name: bone trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "bone trabecula biogenesis" RELATED [GOC:dph] +synonym: "bone trabeculation" EXACT [GOC:dph] +synonym: "skeletal trabecula biogenesis" RELATED [GOC:dph] +synonym: "skeletal trabecula formation" EXACT [GOC:dph] +synonym: "skeletal trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0061430 ! bone trabecula morphogenesis + +[Term] +id: GO:0060347 +name: heart trabecula formation +namespace: biological_process +def: "The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:dph] +synonym: "cardiac trabecula formation" EXACT [GOC:dph] +synonym: "cardiac trabeculation" EXACT [GOC:dph] +synonym: "heart trabecula biogenesis" RELATED [GOC:dph] +synonym: "heart trabeculation" EXACT [GOC:dph] +is_a: GO:0060343 ! trabecula formation +relationship: part_of GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0061384 ! heart trabecula morphogenesis + +[Term] +id: GO:0060348 +name: bone development +namespace: biological_process +def: "The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." [GOC:dph] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0001501 ! skeletal system development + +[Term] +id: GO:0060349 +name: bone morphogenesis +namespace: biological_process +def: "The process in which bones are generated and organized." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0048705 ! skeletal system morphogenesis +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0060350 +name: endochondral bone morphogenesis +namespace: biological_process +def: "The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone." [GOC:dph, PMID:11680679] +is_a: GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0060351 +name: cartilage development involved in endochondral bone morphogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones." [GOC:dph] +is_a: GO:0051216 ! cartilage development +relationship: part_of GO:0060350 ! endochondral bone morphogenesis + +[Term] +id: GO:0060352 +name: cell adhesion molecule production +namespace: biological_process +def: "The appearance of a cell adhesion molecule due to biosynthesis or secretion." [GOC:BHF, GOC:rl] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0060353 +name: regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060354 +name: negative regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0060353 ! regulation of cell adhesion molecule production +relationship: negatively_regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060355 +name: positive regulation of cell adhesion molecule production +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." [GOC:BHF, GOC:rl] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0060353 ! regulation of cell adhesion molecule production +relationship: positively_regulates GO:0060352 ! cell adhesion molecule production + +[Term] +id: GO:0060357 +name: regulation of leucine import +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "regulation of L-leucine import" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of L-leucine uptake" NARROW [GOC:dph, GOC:tb] +synonym: "regulation of leucine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +is_a: GO:1905532 ! regulation of leucine import across plasma membrane +relationship: regulates GO:1903801 ! L-leucine import across plasma membrane + +[Term] +id: GO:0060358 +name: negative regulation of leucine import +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +is_a: GO:0060357 ! regulation of leucine import +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905533 ! negative regulation of leucine import across plasma membrane +relationship: negatively_regulates GO:1903801 ! L-leucine import across plasma membrane + +[Term] +id: GO:0060359 +name: response to ammonium ion +namespace: biological_process +alt_id: GO:1903717 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] +synonym: "response to ammonia" EXACT [] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0060360 +name: negative regulation of leucine import in response to ammonium ion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] +synonym: "negative regulation of leucine uptake in response to ammonium ion" EXACT [] +is_a: GO:0060358 ! negative regulation of leucine import +relationship: part_of GO:0071242 ! cellular response to ammonium ion + +[Term] +id: GO:0060361 +name: flight +namespace: biological_process +def: "Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement." [GOC:dph] +is_a: GO:0040011 ! locomotion + +[Term] +id: GO:0060362 +name: flight involved in flight behavior +namespace: biological_process +def: "Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight." [GOC:dph] +is_a: GO:0031987 ! locomotion involved in locomotory behavior +is_a: GO:0060361 ! flight +relationship: part_of GO:0007629 ! flight behavior + +[Term] +id: GO:0060363 +name: cranial suture morphogenesis +namespace: biological_process +def: "The process in which any suture between cranial bones is generated and organized." [GOC:dph, GOC:pr, GOC:sl] +is_a: GO:0097094 ! craniofacial suture morphogenesis + +[Term] +id: GO:0060364 +name: frontal suture morphogenesis +namespace: biological_process +def: "The process in which the frontal suture is generated and organized." [GOC:dph, GOC:sl] +synonym: "interfrontal suture morphogenesis" EXACT [] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060365 +name: coronal suture morphogenesis +namespace: biological_process +def: "The process in which the coronal suture is generated and organized." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060366 +name: lambdoid suture morphogenesis +namespace: biological_process +def: "The process in which the lambdoid suture is generated and organized." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060367 +name: sagittal suture morphogenesis +namespace: biological_process +def: "The process in which the sagittal suture is generated and organized." [GOC:dph, GOC:sl] +is_a: GO:0060363 ! cranial suture morphogenesis + +[Term] +id: GO:0060368 +name: regulation of Fc receptor mediated stimulatory signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:dph, GOC:tb] +synonym: "regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway + +[Term] +id: GO:0060369 +name: positive regulation of Fc receptor mediated stimulatory signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the Fc receptor mediated stimulatory signaling pathway. The Fc receptor mediated stimulatory signaling pathway is a series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of Fc receptor mediated stimulatory signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway +relationship: positively_regulates GO:0002431 ! Fc receptor mediated stimulatory signaling pathway + +[Term] +id: GO:0060370 +name: susceptibility to T cell mediated cytotoxicity +namespace: biological_process +def: "The process of causing a cell to become susceptible to T cell mediated cytotoxicity." [GOC:dph, GOC:tb] +is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity + +[Term] +id: GO:0060371 +name: regulation of atrial cardiac muscle cell membrane depolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] +synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] +synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of atrial cardiac muscle cell depolarization" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of atrial cardiomyocyte membrane depolarization" EXACT [] +is_a: GO:0003254 ! regulation of membrane depolarization + +[Term] +id: GO:0060372 +name: regulation of atrial cardiac muscle cell membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte." [GOC:dph, GOC:tb] +synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] +synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of atrial cardiac muscle cell repolarization" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of atrial cardiomyocyte membrane repolarization" EXACT [] +is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization +relationship: regulates GO:0099624 ! atrial cardiac muscle cell membrane repolarization + +[Term] +id: GO:0060373 +name: regulation of ventricular cardiac muscle cell membrane depolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte." [GOC:dph, GOC:tb] +synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiomyocyte membrane depolarization" EXACT [] +synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0003254 ! regulation of membrane depolarization + +[Term] +id: GO:0060374 +name: mast cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] +is_a: GO:0002573 ! myeloid leukocyte differentiation + +[Term] +id: GO:0060375 +name: regulation of mast cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] +is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation +relationship: regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060376 +name: positive regulation of mast cell differentiation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] +is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation +is_a: GO:0060375 ! regulation of mast cell differentiation +relationship: positively_regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060377 +name: negative regulation of mast cell differentiation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [GOC:dph, GOC:tb] +is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation +is_a: GO:0060375 ! regulation of mast cell differentiation +relationship: negatively_regulates GO:0060374 ! mast cell differentiation + +[Term] +id: GO:0060378 +name: regulation of brood size +namespace: biological_process +def: "Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:dph, GOC:tb] +is_a: GO:0044706 ! multi-multicellular organism process +is_a: GO:0048609 ! multicellular organismal reproductive process +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0060379 +name: cardiac muscle cell myoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:dph, GOC:tb] +synonym: "cardiac myoblast differentiation" RELATED [GOC:dph, GOC:tb] +synonym: "myocardial precursor cell differentiation" EXACT [GOC:mtg_heart] +is_a: GO:0010002 ! cardioblast differentiation +is_a: GO:0045445 ! myoblast differentiation + +[Term] +id: GO:0060380 +name: regulation of single-stranded telomeric DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of binding to single-stranded telomeric DNA." [GOC:dph, GOC:tb] +synonym: "regulation of telomeric ssDNA binding" EXACT [GOC:mah] +is_a: GO:1904742 ! regulation of telomeric DNA binding + +[Term] +id: GO:0060381 +name: positive regulation of single-stranded telomeric DNA binding +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of single-stranded telomeric DNA binding." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of telomeric ssDNA binding" EXACT [GOC:mah] +is_a: GO:0060380 ! regulation of single-stranded telomeric DNA binding +is_a: GO:1904744 ! positive regulation of telomeric DNA binding + +[Term] +id: GO:0060382 +name: regulation of DNA strand elongation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0022616 ! DNA strand elongation + +[Term] +id: GO:0060383 +name: positive regulation of DNA strand elongation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:mah] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0060382 ! regulation of DNA strand elongation +relationship: positively_regulates GO:0022616 ! DNA strand elongation + +[Term] +id: GO:0060384 +name: innervation +namespace: biological_process +def: "The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue." [GOC:dph, GOC:sart] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0021675 ! nerve development + +[Term] +id: GO:0060385 +name: axonogenesis involved in innervation +namespace: biological_process +def: "The neurite development process that generates a long process of a neuron, as it invades a target tissue." [GOC:dph, GOC:sart] +is_a: GO:0007409 ! axonogenesis +relationship: part_of GO:0060384 ! innervation + +[Term] +id: GO:0060386 +name: synapse assembly involved in innervation +namespace: biological_process +def: "The assembly of a synapse within a target tissue in which a nerve is invading." [GOC:dph, GOC:pr, GOC:sart] +synonym: "synapse biogenesis involved in innervation" EXACT [] +synonym: "synaptogenesis involved in innervation" EXACT [] +is_a: GO:0007416 ! synapse assembly +relationship: part_of GO:0060384 ! innervation + +[Term] +id: GO:0060387 +name: fertilization envelope +namespace: cellular_component +def: "A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release." [GOC:dph, ISBN:0878932437] +synonym: "fertilization membrane" RELATED [] +is_a: GO:0035805 ! egg coat + +[Term] +id: GO:0060388 +name: vitelline envelope +namespace: cellular_component +def: "A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization." [GOC:dph, ISBN:0878932437] +synonym: "fertilization membrane" RELATED [] +is_a: GO:0035805 ! egg coat + +[Term] +id: GO:0060389 +name: pathway-restricted SMAD protein phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor." [GOC:dph, ISBN:3527303782] +synonym: "pathway restricted SMAD protein phosphorylation" EXACT [GOC:rl] +synonym: "R-SMAD protein phosphorylation" EXACT [GOC:rl] +synonym: "receptor regulated SMAD protein phosphorylation" EXACT [GOC:rl] +synonym: "receptor-regulated SMAD protein phosphorylation" EXACT [GOC:rl] +is_a: GO:0006468 ! protein phosphorylation +relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0060390 +name: regulation of SMAD protein signal transduction +namespace: biological_process +alt_id: GO:0007184 +def: "Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] +synonym: "SMAD protein import into nucleus" NARROW [] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0060395 ! SMAD protein signal transduction + +[Term] +id: GO:0060391 +name: positive regulation of SMAD protein signal transduction +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of SMAD protein import into nucleus" NARROW [] +synonym: "positive regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] +is_a: GO:0060390 ! regulation of SMAD protein signal transduction +is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: positively_regulates GO:0060395 ! SMAD protein signal transduction + +[Term] +id: GO:0060392 +name: negative regulation of SMAD protein signal transduction +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "negative regulation of SMAD protein import into nucleus" NARROW [] +synonym: "negative regulation of SMAD protein nuclear translocation" NARROW [GOC:mah] +is_a: GO:0060390 ! regulation of SMAD protein signal transduction +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0060395 ! SMAD protein signal transduction + +[Term] +id: GO:0060393 +name: regulation of pathway-restricted SMAD protein phosphorylation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation + +[Term] +id: GO:0060394 +name: negative regulation of pathway-restricted SMAD protein phosphorylation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation +is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation + +[Term] +id: GO:0060395 +name: SMAD protein signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0060396 +name: growth hormone receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph, PMID:11445442] +synonym: "cellular response to growth hormone" RELATED [GOC:dph] +synonym: "GH receptor signaling pathway" RELATED [GOC:dph] +synonym: "growth hormone receptor signalling pathway" EXACT [GOC:dph] +is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway +relationship: part_of GO:0071378 ! cellular response to growth hormone stimulus + +[Term] +id: GO:0060397 +name: growth hormone receptor signaling pathway via JAK-STAT +namespace: biological_process +def: "The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:BHF, GOC:dph, PMID:11445442] +synonym: "JAK-STAT cascade involved in growth hormone signalling pathway" EXACT [GOC:dph] +is_a: GO:0060396 ! growth hormone receptor signaling pathway + +[Term] +id: GO:0060398 +name: regulation of growth hormone receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] +synonym: "regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0060396 ! growth hormone receptor signaling pathway + +[Term] +id: GO:0060399 +name: positive regulation of growth hormone receptor signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:BHF, GOC:dph] +synonym: "positive regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway +relationship: positively_regulates GO:0060396 ! growth hormone receptor signaling pathway + +[Term] +id: GO:0060400 +name: negative regulation of growth hormone receptor signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the growth hormone receptor signaling pathway. The growth hormone receptor signaling pathway is the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand." [GOC:dph] +synonym: "negative regulation of growth hormone receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0060398 ! regulation of growth hormone receptor signaling pathway +relationship: negatively_regulates GO:0060396 ! growth hormone receptor signaling pathway + +[Term] +id: GO:0060401 +name: cytosolic calcium ion transport +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into, out of or within the cytosol." [GOC:dph, GOC:tb] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0060402 +name: calcium ion transport into cytosol +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into the cytosol." [GOC:dph, GOC:tb] +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0060401 ! cytosolic calcium ion transport + +[Term] +id: GO:0060404 +name: axonemal microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [GOC:cilia, GOC:dph, GOC:krc, GOC:tb] +is_a: GO:0010938 ! cytoplasmic microtubule depolymerization +is_a: GO:0061523 ! cilium disassembly + +[Term] +id: GO:0060405 +name: regulation of penile erection +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:add, GOC:dph, GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0043084 ! penile erection + +[Term] +id: GO:0060406 +name: positive regulation of penile erection +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060405 ! regulation of penile erection +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0043084 ! penile erection + +[Term] +id: GO:0060407 +name: negative regulation of penile erection +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:dph, GOC:tb] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060405 ! regulation of penile erection +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0043084 ! penile erection + +[Term] +id: GO:0060408 +name: regulation of acetylcholine metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0033238 ! regulation of cellular amine metabolic process +is_a: GO:0080090 ! regulation of primary metabolic process +relationship: regulates GO:0008291 ! acetylcholine metabolic process + +[Term] +id: GO:0060409 +name: positive regulation of acetylcholine metabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:0060408 ! regulation of acetylcholine metabolic process +relationship: positively_regulates GO:0008291 ! acetylcholine metabolic process + +[Term] +id: GO:0060410 +name: negative regulation of acetylcholine metabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:dph, GOC:tb] +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:0060408 ! regulation of acetylcholine metabolic process +relationship: negatively_regulates GO:0008291 ! acetylcholine metabolic process + +[Term] +id: GO:0060411 +name: cardiac septum morphogenesis +namespace: biological_process +alt_id: GO:0003280 +def: "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart." [GOC:dph, GOC:mtg_heart] +synonym: "heart septum morphogenesis" EXACT [] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0003206 ! cardiac chamber morphogenesis +relationship: part_of GO:0003279 ! cardiac septum development + +[Term] +id: GO:0060412 +name: ventricular septum morphogenesis +namespace: biological_process +def: "The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another." [GOC:dph] +synonym: "interventricular septum morphogenesis" EXACT [GOC:dph] +is_a: GO:0060411 ! cardiac septum morphogenesis +relationship: part_of GO:0003281 ! ventricular septum development + +[Term] +id: GO:0060413 +name: atrial septum morphogenesis +namespace: biological_process +alt_id: GO:0003287 +def: "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another." [GOC:dph, GOC:mtg_heart] +synonym: "interatrial septum morphogenesis" EXACT [GOC:dph] +is_a: GO:0060411 ! cardiac septum morphogenesis +relationship: part_of GO:0003209 ! cardiac atrium morphogenesis +relationship: part_of GO:0003283 ! atrial septum development + +[Term] +id: GO:0060414 +name: aorta smooth muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body." [GOC:bf, GOC:dgh, GOC:dph, Wikipedia:Aorta] +is_a: GO:0060415 ! muscle tissue morphogenesis +relationship: part_of GO:0035909 ! aorta morphogenesis +relationship: part_of GO:0048745 ! smooth muscle tissue development + +[Term] +id: GO:0060415 +name: muscle tissue morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function." [GOC:dph] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0048644 ! muscle organ morphogenesis + +[Term] +id: GO:0060416 +name: response to growth hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:BHF, GOC:dph] +synonym: "response to growth hormone stimulus" EXACT [GOC:dos] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0060417 +name: yolk +namespace: cellular_component +def: "The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo." [GOC:dph, GOC:tb, PMID:18046696] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0060418 +name: yolk plasma +namespace: cellular_component +def: "Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:dph, GOC:tb, PMID:18046696] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0060417 ! yolk + +[Term] +id: GO:0060419 +name: heart growth +namespace: biological_process +def: "The increase in size or mass of the heart." [GOC:dph, GOC:tb] +is_a: GO:0035265 ! organ growth +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060420 +name: regulation of heart growth +namespace: biological_process +def: "Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:tb] +is_a: GO:0046620 ! regulation of organ growth +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0060419 ! heart growth + +[Term] +id: GO:0060421 +name: positive regulation of heart growth +namespace: biological_process +def: "Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0046622 ! positive regulation of organ growth +is_a: GO:0060420 ! regulation of heart growth +relationship: positively_regulates GO:0060419 ! heart growth + +[Term] +id: GO:0060422 +name: peptidyl-dipeptidase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain." [GOC:dph, GOC:tb] +is_a: GO:0030414 ! peptidase inhibitor activity + +[Term] +id: GO:0060423 +name: foregut regionalization +namespace: biological_process +def: "The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:dph, GOC:mtg_lung] +is_a: GO:0009952 ! anterior/posterior pattern specification + +[Term] +id: GO:0060424 +name: lung field specification +namespace: biological_process +def: "The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung] +synonym: "lung specification" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0010092 ! specification of animal organ identity +is_a: GO:0060423 ! foregut regionalization +relationship: part_of GO:0060431 ! primary lung bud formation + +[Term] +id: GO:0060425 +name: lung morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the lung are generated and organized." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060426 +name: lung vasculature development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary vasculature development" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0001944 ! vasculature development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060427 +name: lung connective tissue development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary connective tissue development" EXACT [] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060428 +name: lung epithelium development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary epithelium development" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060429 +name: epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:dph, GOC:mtg_lung] +subset: goslim_drosophila +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0060430 +name: lung saccule development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells." [GOC:dph, GOC:mtg_lung] +synonym: "lung saccular development" BROAD [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048286 ! lung alveolus development + +[Term] +id: GO:0060431 +name: primary lung bud formation +namespace: biological_process +def: "The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds." [GOC:dph, GOC:mtg_lung] +synonym: "lung formation" EXACT [GOC:dph] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0048645 ! animal organ formation +is_a: GO:0060441 ! epithelial tube branching involved in lung morphogenesis +is_a: GO:0060572 ! morphogenesis of an epithelial bud + +[Term] +id: GO:0060432 +name: lung pattern specification process +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate." [GOC:dph] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060433 +name: bronchus development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0030323 ! respiratory tube development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0060434 +name: bronchus morphogenesis +namespace: biological_process +def: "The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0060433 ! bronchus development + +[Term] +id: GO:0060435 +name: bronchiole development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph, GOC:mtg_lung] +is_a: GO:0030323 ! respiratory tube development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060436 +name: bronchiole morphogenesis +namespace: biological_process +def: "The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi." [GOC:dph] +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0060435 ! bronchiole development + +[Term] +id: GO:0060437 +name: lung growth +namespace: biological_process +def: "The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:dph] +is_a: GO:0035265 ! organ growth +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060438 +name: trachea development +namespace: biological_process +def: "The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0060439 +name: trachea morphogenesis +namespace: biological_process +def: "The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0060438 ! trachea development + +[Term] +id: GO:0060440 +name: trachea formation +namespace: biological_process +def: "The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches." [GOC:dph] +is_a: GO:0048645 ! animal organ formation +relationship: part_of GO:0060439 ! trachea morphogenesis + +[Term] +id: GO:0060441 +name: epithelial tube branching involved in lung morphogenesis +namespace: biological_process +def: "The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:mtg_lung] +synonym: "lung branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0060425 ! lung morphogenesis + +[Term] +id: GO:0060442 +name: branching involved in prostate gland morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] +synonym: "prostate branching" RELATED [GOC:dph] +synonym: "prostate gland branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0060740 ! prostate gland epithelium morphogenesis +is_a: GO:0061138 ! morphogenesis of a branching epithelium + +[Term] +id: GO:0060443 +name: mammary gland morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060444 +name: branching involved in mammary gland duct morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph] +synonym: "mammary gland branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060445 +name: branching involved in salivary gland morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the salivary gland is generated and organized." [GOC:dph] +is_a: GO:0061138 ! morphogenesis of a branching epithelium +relationship: part_of GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0060446 +name: branching involved in open tracheal system development +namespace: biological_process +def: "The process in which the anatomical structures of branches in the open tracheal system are generated and organized." [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0007424 ! open tracheal system development + +[Term] +id: GO:0060447 +name: bud outgrowth involved in lung branching +namespace: biological_process +def: "The process in which a region of the lung epithelium initiates an outgrowth." [GOC:dph, GOC:mtg_lung] +synonym: "bud formation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0060602 ! branch elongation of an epithelium +relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0060448 +name: dichotomous subdivision of terminal units involved in lung branching +namespace: biological_process +def: "The process in which a lung bud bifurcates." [GOC:dph, GOC:mtg_lung] +synonym: "bud bifurcation involved in lung branching" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit +relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0060449 +name: bud elongation involved in lung branching +namespace: biological_process +def: "The process in which a bud in the lung grows out from the point where it is formed." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060602 ! branch elongation of an epithelium +relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0060450 +name: positive regulation of hindgut contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] +is_a: GO:0043134 ! regulation of hindgut contraction +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +is_a: GO:0060456 ! positive regulation of digestive system process +relationship: positively_regulates GO:0043133 ! hindgut contraction + +[Term] +id: GO:0060451 +name: negative regulation of hindgut contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:dph, GOC:tb] +is_a: GO:0043134 ! regulation of hindgut contraction +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +is_a: GO:0060457 ! negative regulation of digestive system process +relationship: negatively_regulates GO:0043133 ! hindgut contraction + +[Term] +id: GO:0060452 +name: positive regulation of cardiac muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cardiac muscle contraction." [GOC:dph, GOC:tb] +is_a: GO:0045823 ! positive regulation of heart contraction +is_a: GO:0045989 ! positive regulation of striated muscle contraction +is_a: GO:0055117 ! regulation of cardiac muscle contraction +relationship: positively_regulates GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0060453 +name: regulation of gastric acid secretion +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0060454 +name: positive regulation of gastric acid secretion +namespace: biological_process +def: "Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060453 ! regulation of gastric acid secretion +is_a: GO:0060456 ! positive regulation of digestive system process +relationship: positively_regulates GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0060455 +name: negative regulation of gastric acid secretion +namespace: biological_process +def: "Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:dph, GOC:tb] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060453 ! regulation of gastric acid secretion +is_a: GO:0060457 ! negative regulation of digestive system process +relationship: negatively_regulates GO:0001696 ! gastric acid secretion + +[Term] +id: GO:0060456 +name: positive regulation of digestive system process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0022600 ! digestive system process + +[Term] +id: GO:0060457 +name: negative regulation of digestive system process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:dph, GOC:tb] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0022600 ! digestive system process + +[Term] +id: GO:0060458 +name: right lung development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] +synonym: "right pulmonary development" EXACT [GOC:dph, GOC:mtg_lung] +is_a: GO:0030324 ! lung development + +[Term] +id: GO:0060459 +name: left lung development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect." [GOC:dph, GOC:mtg_lung] +synonym: "left pulmonary development" EXACT [GOC:dph] +is_a: GO:0030324 ! lung development + +[Term] +id: GO:0060460 +name: left lung morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the left lung are generated and organized." [GOC:dph] +is_a: GO:0060425 ! lung morphogenesis +relationship: part_of GO:0060459 ! left lung development + +[Term] +id: GO:0060461 +name: right lung morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the right lung are generated and organized." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060425 ! lung morphogenesis +relationship: part_of GO:0060458 ! right lung development + +[Term] +id: GO:0060462 +name: lung lobe development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060463 +name: lung lobe morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060425 ! lung morphogenesis +relationship: part_of GO:0060462 ! lung lobe development + +[Term] +id: GO:0060464 +name: lung lobe formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung." [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060463 ! lung lobe morphogenesis + +[Term] +id: GO:0060465 +name: pharynx development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth." [GOC:dph, GOC:rk] +synonym: "pharyngeal development" RELATED [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0060466 +name: activation of meiosis involved in egg activation +namespace: biological_process +def: "Any process that starts the inactive process of meiosis in an egg after the egg has been fertilized or physiologically activated. Eggs generally arrest in meiosis and complete the process after activation." [GOC:dph] +synonym: "reactivation of meiosis after fertilization" NARROW [GOC:dph] +synonym: "resumption of meiosis involved in egg activation" EXACT [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0090427 ! activation of meiosis +relationship: part_of GO:0007343 ! egg activation + +[Term] +id: GO:0060467 +name: negative regulation of fertilization +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:dph] +is_a: GO:0080154 ! regulation of fertilization +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0009566 ! fertilization + +[Term] +id: GO:0060468 +name: prevention of polyspermy +namespace: biological_process +def: "The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg." [GOC:dph] +synonym: "negative regulation of fertilization involved in egg activation" EXACT [GOC:dph] +synonym: "polyspermy block" EXACT [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0060467 ! negative regulation of fertilization +relationship: part_of GO:0007343 ! egg activation + +[Term] +id: GO:0060469 +name: positive regulation of transcription involved in egg activation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of transcription as a part of the process of egg activation." [GOC:dph] +synonym: "activation of the egg genome" RELATED [GOC:dph] +synonym: "activation of the maternal genome" RELATED [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: part_of GO:0007343 ! egg activation + +[Term] +id: GO:0060470 +name: positive regulation of cytosolic calcium ion concentration involved in egg activation +namespace: biological_process +def: "The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg." [GOC:dph] +synonym: "elevation of cytosolic calcium ion concentration involved in egg activation" EXACT [] +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007343 ! egg activation + +[Term] +id: GO:0060471 +name: cortical granule exocytosis +namespace: biological_process +def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy." [GOC:dph] +synonym: "cortical granule release" RELATED [GOC:dph] +synonym: "cortical reaction" RELATED [PMID:22088197] +is_a: GO:0017156 ! calcium-ion regulated exocytosis +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0060468 ! prevention of polyspermy + +[Term] +id: GO:0060472 +name: positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol." [GOC:dph] +synonym: "positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration" EXACT [] +is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis +is_a: GO:0050865 ! regulation of cell activation +is_a: GO:0060470 ! positive regulation of cytosolic calcium ion concentration involved in egg activation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060471 ! cortical granule exocytosis + +[Term] +id: GO:0060473 +name: cortical granule +namespace: cellular_component +def: "A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy." [GOC:dph] +synonym: "cortical vesicle" RELATED [GOC:dph] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0060474 +name: positive regulation of flagellated sperm motility involved in capacitation +namespace: biological_process +def: "The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence." [GOC:cilia, GOC:dph, GOC:krc] +synonym: "positive regulation of sperm motility involved in capacitation" RELATED [] +is_a: GO:0022414 ! reproductive process +is_a: GO:1902093 ! positive regulation of flagellated sperm motility +relationship: part_of GO:0048240 ! sperm capacitation + +[Term] +id: GO:0060475 +name: positive regulation of actin filament polymerization involved in acrosome reaction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin polymerization as part of the acrosome reaction." [GOC:dph] +synonym: "positive regulation of actin polymerization involved in acrosome reaction" RELATED [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0030838 ! positive regulation of actin filament polymerization +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0060476 +name: protein localization involved in acrosome reaction +namespace: biological_process +def: "The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." [GOC:dph] +synonym: "protein localisation involved in acrosome reaction" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0030029 ! actin filament-based process +is_a: GO:0034613 ! cellular protein localization +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0060477 +name: obsolete peptidyl-serine phosphorylation involved in acrosome reaction +namespace: biological_process +def: "OBSOLETE. The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine that is part of the acrosome reaction." [GOC:dph] +comment: The reason for obsoletion is that this term does not represent a specific process. +is_obsolete: true + +[Term] +id: GO:0060478 +name: acrosomal vesicle exocytosis +namespace: biological_process +def: "The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction." [GOC:dph] +synonym: "acrosomal granule exocytosis" RELATED [GOC:dph] +synonym: "acrosome exocytosis" EXACT [GOC:dph] +is_a: GO:0017156 ! calcium-ion regulated exocytosis +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0060479 +name: lung cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary cell differentiation" EXACT [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060480 +name: lung goblet cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary goblet cell differentiation" EXACT [] +is_a: GO:0002067 ! glandular epithelial cell differentiation +is_a: GO:0061140 ! lung secretory cell differentiation +relationship: part_of GO:0060481 ! lobar bronchus epithelium development + +[Term] +id: GO:0060481 +name: lobar bronchus epithelium development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060428 ! lung epithelium development +relationship: part_of GO:0060482 ! lobar bronchus development + +[Term] +id: GO:0060482 +name: lobar bronchus development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060433 ! bronchus development + +[Term] +id: GO:0060483 +name: lobar bronchus mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060484 ! lung-associated mesenchyme development +relationship: part_of GO:0060482 ! lobar bronchus development + +[Term] +id: GO:0060484 +name: lung-associated mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung." [GOC:dph, GOC:mtg_lung] +synonym: "lung mesenchyme development" EXACT [GOC:dph] +synonym: "pulmonary mesenchyme development" EXACT [GOC:dph] +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060485 +name: mesenchyme development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:dph] +synonym: "mesenchymal development" EXACT [GOC:dph] +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0060486 +name: club cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." [GOC:dph, GOC:mtg_lung, PMID:28144783] +synonym: "Clara cell differentiation" EXACT [PMID:28144783] +is_a: GO:0060487 ! lung epithelial cell differentiation + +[Term] +id: GO:0060487 +name: lung epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung." [GOC:dph] +synonym: "pulmonary epithelial cell differentiation" RELATED [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0060479 ! lung cell differentiation +relationship: part_of GO:0060428 ! lung epithelium development + +[Term] +id: GO:0060488 +name: orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis +namespace: biological_process +def: "The process in which a lung bud bifurcates perpendicular to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] +synonym: "perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching + +[Term] +id: GO:0060489 +name: planar dichotomous subdivision of terminal units involved in lung branching morphogenesis +namespace: biological_process +def: "The process in which a lung bud bifurcates parallel to the plane of the previous bud." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060448 ! dichotomous subdivision of terminal units involved in lung branching + +[Term] +id: GO:0060490 +name: lateral sprouting involved in lung morphogenesis +namespace: biological_process +def: "The process in which a branch forms along the side of the lung epithelial tube." [GOC:dph, GOC:mtg_lung] +is_a: GO:0060601 ! lateral sprouting from an epithelium +relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0060491 +name: regulation of cell projection assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cell projection assembly." [GOC:dph, GOC:tb] +synonym: "regulation of cell projection formation" RELATED [GOC:dph, GOC:tb] +is_a: GO:0031344 ! regulation of cell projection organization +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0030031 ! cell projection assembly + +[Term] +id: GO:0060492 +name: lung induction +namespace: biological_process +def: "The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung." [GOC:dph] +is_a: GO:0001759 ! organ induction +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis +relationship: positively_regulates GO:0060424 ! lung field specification + +[Term] +id: GO:0060493 +name: mesenchymal-endodermal cell signaling involved in lung induction +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud." [GOC:dph, GOC:mtg_lung] +synonym: "mesenchymal-endodermal cell signalling involved in lung induction" EXACT [GOC:mah] +is_a: GO:0060494 ! inductive mesenchymal-endodermal cell signaling +is_a: GO:0060496 ! mesenchymal-epithelial cell signaling involved in lung development +is_a: GO:0060497 ! mesenchymal-endodermal cell signaling +relationship: part_of GO:0060492 ! lung induction + +[Term] +id: GO:0060494 +name: inductive mesenchymal-endodermal cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell." [GOC:dph, GOC:mtg_lung] +synonym: "inductive mesenchymal-endodermal cell signalling" EXACT [GOC:mah] +is_a: GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0060495 +name: cell-cell signaling involved in lung development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure." [GOC:dph, GOC:mtg_lung] +synonym: "cell-cell signalling involved in lung development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060496 +name: mesenchymal-epithelial cell signaling involved in lung development +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung." [GOC:dph, GOC:mtg_lung] +synonym: "mesenchymal-epithelial cell signalling involved in lung development" EXACT [GOC:mah] +is_a: GO:0060495 ! cell-cell signaling involved in lung development +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling + +[Term] +id: GO:0060497 +name: mesenchymal-endodermal cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell." [GOC:dph] +synonym: "mesenchymal-endodermal cell signalling" EXACT [GOC:mah] +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling + +[Term] +id: GO:0060498 +name: retinoic acid receptor signaling pathway involved in lung bud formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud." [GOC:dph, GOC:mtg_lung] +synonym: "retinoic acid receptor signalling pathway involved in lung bud formation" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0060431 ! primary lung bud formation + +[Term] +id: GO:0060499 +name: fibroblast growth factor receptor signaling pathway involved in lung induction +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus." [GOC:dph, GOC:mtg_lung] +synonym: "fibroblast growth factor receptor signalling pathway involved in lung induction" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0031131 ! reception of an inductive signal +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction + +[Term] +id: GO:0060500 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in lung bud formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the initial primordium of the lung is formed." [GOC:dph, GOC:mtg_lung] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0060431 + +[Term] +id: GO:0060501 +name: positive regulation of epithelial cell proliferation involved in lung morphogenesis +namespace: biological_process +def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape." [GOC:dph] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis +relationship: positively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis + +[Term] +id: GO:0060502 +name: epithelial cell proliferation involved in lung morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung." [GOC:dph] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0060425 ! lung morphogenesis +relationship: part_of GO:0060428 ! lung epithelium development + +[Term] +id: GO:0060503 +name: bud dilation involved in lung branching +namespace: biological_process +def: "The process in which a bud in the lung increases radially." [GOC:dph] +synonym: "bud expansion" EXACT [GOC:dph] +is_a: GO:0003401 ! axis elongation +relationship: part_of GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0060504 +name: positive regulation of epithelial cell proliferation involved in lung bud dilation +namespace: biological_process +def: "Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially." [GOC:dph] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:0060501 ! positive regulation of epithelial cell proliferation involved in lung morphogenesis +is_a: GO:0061047 ! positive regulation of branching involved in lung morphogenesis +relationship: positively_regulates GO:0060505 ! epithelial cell proliferation involved in lung bud dilation + +[Term] +id: GO:0060505 +name: epithelial cell proliferation involved in lung bud dilation +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells that contribute to the radial growth of a lung bud." [GOC:dph] +is_a: GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis +relationship: part_of GO:0060503 ! bud dilation involved in lung branching + +[Term] +id: GO:0060506 +name: smoothened signaling pathway involved in lung development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] +synonym: "hedgehog signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in lung development" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway involved in lung development" EXACT [GOC:mah] +is_a: GO:0007224 ! smoothened signaling pathway +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development + +[Term] +id: GO:0060507 +name: epidermal growth factor receptor signaling pathway involved in lung development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development." [GOC:dph, GOC:mtg_lung] +synonym: "epidermal growth factor receptor signalling pathway involved in lung development" EXACT [GOC:mah] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0060495 ! cell-cell signaling involved in lung development + +[Term] +id: GO:0060508 +name: lung basal cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary basal cell differentiation" BROAD [GOC:dph, GOC:mtg_lung] +is_a: GO:0060479 ! lung cell differentiation +relationship: part_of GO:0060428 ! lung epithelium development + +[Term] +id: GO:0060509 +name: type I pneumocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] +synonym: "membranous pneumocyte differentiation" EXACT [GOC:dph, ISBN:0721662544] +synonym: "small alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] +synonym: "squamous alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] +is_a: GO:0060487 ! lung epithelial cell differentiation + +[Term] +id: GO:0060510 +name: type II pneumocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies." [GOC:dph, GOC:mtg_lung, ISBN:0721662544] +synonym: "granular pneumocyte differentiation" RELATED [GOC:dph, ISBN:0721662544] +synonym: "great alveolar cell differentiation" EXACT [GOC:dph, ISBN:0721662544] +synonym: "large alveolar cell differentiation" RELATED [GOC:dph, ISBN:0721662544] +is_a: GO:0061140 ! lung secretory cell differentiation + +[Term] +id: GO:0060511 +name: creation of an inductive signal by a mesenchymal cell involved in lung induction +namespace: biological_process +def: "The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud." [GOC:dph, GOC:mtg_lung] +is_a: GO:0031130 ! creation of an inductive signal +relationship: part_of GO:0060493 ! mesenchymal-endodermal cell signaling involved in lung induction + +[Term] +id: GO:0060512 +name: prostate gland morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a prostate gland are generated and organized." [GOC:dph, PMID:18977204] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060513 +name: prostatic bud formation +namespace: biological_process +def: "The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph, PMID:18977204] +synonym: "primary prostate bud formation" EXACT [GOC:dph] +synonym: "prostate ductal budding" EXACT [GOC:dph, PMID:11401393] +synonym: "prostate gland formation" EXACT [GOC:dph] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0048645 ! animal organ formation +is_a: GO:0060572 ! morphogenesis of an epithelial bud +is_a: GO:0060601 ! lateral sprouting from an epithelium +is_a: GO:0060740 ! prostate gland epithelium morphogenesis + +[Term] +id: GO:0060514 +name: prostate induction +namespace: biological_process +def: "The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, PMID:18977204] +is_a: GO:0001759 ! organ induction +is_a: GO:0060685 ! regulation of prostatic bud formation +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060515 ! prostate field specification + +[Term] +id: GO:0060515 +name: prostate field specification +namespace: biological_process +def: "The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GOC:dph, PMID:18977204] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010092 ! specification of animal organ identity +relationship: part_of GO:0060513 ! prostatic bud formation + +[Term] +id: GO:0060516 +name: primary prostatic bud elongation +namespace: biological_process +def: "The increase in size of the prostatic bud as it forms." [GOC:dph, PMID:18977204] +synonym: "prostate bud elongation" BROAD [GOC:dph] +synonym: "prostate bud elongation involved in prostate morphogenesis" EXACT [GOC:dph] +is_a: GO:0060602 ! branch elongation of an epithelium +is_a: GO:0060737 ! prostate gland morphogenetic growth +is_a: GO:0060740 ! prostate gland epithelium morphogenesis + +[Term] +id: GO:0060517 +name: epithelial cell proliferation involved in prostatic bud elongation +namespace: biological_process +def: "The multiplication of epithelial cells, contributing to the expansion of the primary prostatic bud." [GOC:dph, PMID:18977204] +is_a: GO:0060767 ! epithelial cell proliferation involved in prostate gland development +relationship: part_of GO:0060516 ! primary prostatic bud elongation + +[Term] +id: GO:0060518 +name: cell migration involved in prostatic bud elongation +namespace: biological_process +def: "The orderly movement of epithelial cells from one site to another contributing to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] +is_a: GO:0010631 ! epithelial cell migration +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0060516 ! primary prostatic bud elongation + +[Term] +id: GO:0060519 +name: cell adhesion involved in prostatic bud elongation +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud." [GOC:dph, PMID:18977204] +is_a: GO:0007155 ! cell adhesion +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0060516 ! primary prostatic bud elongation + +[Term] +id: GO:0060520 +name: activation of prostate induction by androgen receptor signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland." [GOC:dph, GOC:tb, PMID:18977204] +synonym: "activation of prostate induction by androgen receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0030521 ! androgen receptor signaling pathway +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0060685 ! regulation of prostatic bud formation +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060514 ! prostate induction + +[Term] +id: GO:0060521 +name: mesenchymal-epithelial cell signaling involved in prostate induction +namespace: biological_process +def: "Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate." [GOC:dph, PMID:18977204] +synonym: "mesenchymal-epithelial cell signalling involved in prostate induction" EXACT [GOC:mah] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060522 ! inductive mesenchymal to epithelial cell signaling +is_a: GO:0060739 ! mesenchymal-epithelial cell signaling involved in prostate gland development +relationship: part_of GO:0060514 ! prostate induction + +[Term] +id: GO:0060522 +name: inductive mesenchymal to epithelial cell signaling +namespace: biological_process +def: "Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells." [GOC:dph] +synonym: "inductive mesenchymal to epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0031129 ! inductive cell-cell signaling + +[Term] +id: GO:0060523 +name: prostate epithelial cord elongation +namespace: biological_process +def: "The developmental growth process in which solid chords of prostate epithelium increase in length." [GOC:dph, PMID:18977204] +is_a: GO:0060602 ! branch elongation of an epithelium +is_a: GO:0060737 ! prostate gland morphogenetic growth +is_a: GO:0060740 ! prostate gland epithelium morphogenesis +relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis + +[Term] +id: GO:0060524 +name: dichotomous subdivision of prostate epithelial cord terminal unit +namespace: biological_process +def: "The process in which a prostate epithelial cord bifurcates at its end." [GOC:dph, PMID:18977204] +synonym: "prostate epithelial cord bifurcation" EXACT [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit +relationship: part_of GO:0060442 ! branching involved in prostate gland morphogenesis + +[Term] +id: GO:0060525 +name: prostate glandular acinus development +namespace: biological_process +def: "The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland." [GOC:dph, PMID:18977204] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060526 +name: prostate glandular acinus morphogenesis +namespace: biological_process +def: "The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland." [GOC:dph] +is_a: GO:0060740 ! prostate gland epithelium morphogenesis +relationship: part_of GO:0060525 ! prostate glandular acinus development + +[Term] +id: GO:0060527 +name: prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis +namespace: biological_process +def: "The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini." [GOC:dph, PMID:18977204] +is_a: GO:0060442 ! branching involved in prostate gland morphogenesis +relationship: part_of GO:0060526 ! prostate glandular acinus morphogenesis + +[Term] +id: GO:0060528 +name: secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate." [GOC:dph, PMID:18977204] +is_a: GO:0002067 ! glandular epithelial cell differentiation +is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development +relationship: part_of GO:0060525 ! prostate glandular acinus development + +[Term] +id: GO:0060529 +name: squamous basal epithelial stem cell differentiation involved in prostate gland acinus development +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate." [GOC:dph, PMID:18977204] +is_a: GO:0002067 ! glandular epithelial cell differentiation +is_a: GO:0048863 ! stem cell differentiation +is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development +relationship: part_of GO:0060525 ! prostate glandular acinus development + +[Term] +id: GO:0060530 +name: smooth muscle cell differentiation involved in prostate glandular acinus development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus." [GOC:dph, PMID:18977204] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0051145 ! smooth muscle cell differentiation +relationship: part_of GO:0060525 ! prostate glandular acinus development + +[Term] +id: GO:0060531 +name: neuroendocrine cell differentiation involved in prostate gland acinus development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus." [GOC:dph, PMID:18977204] +is_a: GO:0060742 ! epithelial cell differentiation involved in prostate gland development +is_a: GO:0061101 ! neuroendocrine cell differentiation +relationship: part_of GO:0060525 ! prostate glandular acinus development + +[Term] +id: GO:0060532 +name: bronchus cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph, GOC:mtg_lung] +synonym: "pulmonary cartilage development" EXACT [] +is_a: GO:0051216 ! cartilage development +relationship: part_of GO:0060433 ! bronchus development + +[Term] +id: GO:0060533 +name: bronchus cartilage morphogenesis +namespace: biological_process +def: "The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs." [GOC:dph] +is_a: GO:0060536 ! cartilage morphogenesis +relationship: part_of GO:0060434 ! bronchus morphogenesis +relationship: part_of GO:0060532 ! bronchus cartilage development + +[Term] +id: GO:0060534 +name: trachea cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] +is_a: GO:0051216 ! cartilage development +relationship: part_of GO:0060438 ! trachea development + +[Term] +id: GO:0060535 +name: trachea cartilage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cartilage in the trachea are generated and organized." [GOC:dph] +is_a: GO:0060536 ! cartilage morphogenesis +relationship: part_of GO:0060439 ! trachea morphogenesis +relationship: part_of GO:0060534 ! trachea cartilage development + +[Term] +id: GO:0060536 +name: cartilage morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of cartilage are generated and organized." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0060537 +name: muscle tissue development +namespace: biological_process +def: "The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers." [GOC:dph] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0060538 +name: skeletal muscle organ development +namespace: biological_process +def: "The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue." [GOC:dph] +is_a: GO:0007517 ! muscle organ development + +[Term] +id: GO:0060539 +name: diaphragm development +namespace: biological_process +def: "The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs." [GOC:dph] +is_a: GO:0060538 ! skeletal muscle organ development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0060540 +name: diaphragm morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the diaphragm are generated and organized." [GOC:dph] +is_a: GO:0048644 ! muscle organ morphogenesis +relationship: part_of GO:0060539 ! diaphragm development + +[Term] +id: GO:0060541 +name: respiratory system development +namespace: biological_process +def: "The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange." [GOC:dph] +subset: goslim_drosophila +is_a: GO:0048731 ! system development + +[Term] +id: GO:0060542 +name: regulation of strand invasion +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:tb] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0042148 ! strand invasion + +[Term] +id: GO:0060543 +name: negative regulation of strand invasion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dph, GOC:elh, GOC:tb] +synonym: "negative regulation of D-loop biosynthesis" RELATED [GOC:elh] +synonym: "negative regulation of D-loop formation" RELATED [GOC:elh] +synonym: "negative regulation of Rad51-mediated strand invasion" EXACT [GOC:elh] +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:0060542 ! regulation of strand invasion +relationship: negatively_regulates GO:0042148 ! strand invasion + +[Term] +id: GO:0060544 +name: regulation of necroptotic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "regulation of necroptosis" NARROW [] +is_a: GO:0062098 ! regulation of programmed necrotic cell death +relationship: regulates GO:0070266 ! necroptotic process + +[Term] +id: GO:0060545 +name: positive regulation of necroptotic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "positive regulation of necroptosis" NARROW [] +is_a: GO:0060544 ! regulation of necroptotic process +is_a: GO:0062100 ! positive regulation of programmed necrotic cell death +relationship: positively_regulates GO:0070266 ! necroptotic process + +[Term] +id: GO:0060546 +name: negative regulation of necroptotic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +synonym: "negative regulation of necroptosis" NARROW [] +is_a: GO:0060544 ! regulation of necroptotic process +is_a: GO:0062099 ! negative regulation of programmed necrotic cell death +relationship: negatively_regulates GO:0070266 ! necroptotic process + +[Term] +id: GO:0060547 +name: negative regulation of necrotic cell death +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010939 ! regulation of necrotic cell death +is_a: GO:0060548 ! negative regulation of cell death +relationship: negatively_regulates GO:0070265 ! necrotic cell death + +[Term] +id: GO:0060548 +name: negative regulation of cell death +namespace: biological_process +def: "Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010941 ! regulation of cell death +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0008219 ! cell death + +[Term] +id: GO:0060549 +name: regulation of fructose 1,6-bisphosphate 1-phosphatase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity + +[Term] +id: GO:0060550 +name: positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate 1-phosphatase activity. Fructose 1,6-bisphosphate 1-phosphatase activity is the catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:0060549 ! regulation of fructose 1,6-bisphosphate 1-phosphatase activity + +[Term] +id: GO:0060551 +name: regulation of fructose 1,6-bisphosphate metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process + +[Term] +id: GO:0060552 +name: positive regulation of fructose 1,6-bisphosphate metabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of fructose 1,6-bisphosphate metabolism. Fructose 1,6-bisphosphate metabolism is the chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +is_a: GO:0060551 ! regulation of fructose 1,6-bisphosphate metabolic process +relationship: positively_regulates GO:0030388 ! fructose 1,6-bisphosphate metabolic process + +[Term] +id: GO:0060556 +name: regulation of vitamin D biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0042368 ! vitamin D biosynthetic process + +[Term] +id: GO:0060557 +name: positive regulation of vitamin D biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:BHF, GOC:mah, ISBN:0471331309] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046136 ! positive regulation of vitamin metabolic process +is_a: GO:0060556 ! regulation of vitamin D biosynthetic process +relationship: positively_regulates GO:0042368 ! vitamin D biosynthetic process + +[Term] +id: GO:0060558 +name: regulation of calcidiol 1-monooxygenase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0060559 +name: positive regulation of calcidiol 1-monooxygenase activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity + +[Term] +id: GO:0060560 +name: developmental growth involved in morphogenesis +namespace: biological_process +def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] +synonym: "differential growth" EXACT [GOC:dph] +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0060561 +name: apoptotic process involved in morphogenesis +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of an anatomical structure." [GOC:dph, GOC:mtg_apoptosis] +synonym: "apoptosis involved in development" RELATED [] +synonym: "apoptosis involved in morphogenesis" NARROW [] +synonym: "morphogenetic apoptosis" RELATED [GOC:dph] +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0060562 +name: epithelial tube morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system." [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0035239 ! tube morphogenesis + +[Term] +id: GO:0060563 +name: neuroepithelial cell differentiation +namespace: biological_process +def: "The process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, GOC:tb] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation + +[Term] +id: GO:0060565 +name: obsolete inhibition of APC-Cdc20 complex activity +namespace: biological_process +def: "OBSOLETE. Any process that prevents the activation of APC-Cdc20 complex activity regulating the mitotic cell cycle." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it was not clearly defined and thus used incorrectly in annotation. +synonym: "inhibition of APC activity during mitotic cell cycle" EXACT [GOC:dph, GOC:tb] +synonym: "inhibition of APC-Cdc20 complex activity" EXACT [] +synonym: "inhibition of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "inhibition of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "inhibition of mitotic anaphase-promoting complex activity" RELATED [GOC:vw] +is_obsolete: true +consider: GO:1990948 + +[Term] +id: GO:0060566 +name: positive regulation of DNA-templated transcription, termination +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] +synonym: "positive regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] +synonym: "positive regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "positive regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination +is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +relationship: positively_regulates GO:0006353 ! DNA-templated transcription, termination + +[Term] +id: GO:0060567 +name: negative regulation of DNA-templated transcription, termination +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:dph, GOC:tb, GOC:txnOH] +synonym: "negative regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] +synonym: "negative regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "negative regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +relationship: negatively_regulates GO:0006353 ! DNA-templated transcription, termination + +[Term] +id: GO:0060568 +name: regulation of peptide hormone processing +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0070613 ! regulation of protein processing +relationship: regulates GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0060569 +name: positive regulation of peptide hormone processing +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] +is_a: GO:0010954 ! positive regulation of protein processing +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0060568 ! regulation of peptide hormone processing +relationship: positively_regulates GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0060570 +name: negative regulation of peptide hormone processing +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of peptide hormone processing. Peptide hormone processing is the generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:dph, GOC:tb] +is_a: GO:0010955 ! negative regulation of protein processing +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0060568 ! regulation of peptide hormone processing +relationship: negatively_regulates GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0060571 +name: morphogenesis of an epithelial fold +namespace: biological_process +def: "The morphogenetic process in which an epithelial sheet bends along a linear axis." [GOC:dph] +synonym: "epithelial folding" EXACT [GOC:dph] +synonym: "folding of an epithelial sheet" RELATED [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0060572 +name: morphogenesis of an epithelial bud +namespace: biological_process +def: "The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding." [GOC:dph] +is_a: GO:0060571 ! morphogenesis of an epithelial fold + +[Term] +id: GO:0060573 +name: cell fate specification involved in pattern specification +namespace: biological_process +def: "The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:tb] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification + +[Term] +id: GO:0060574 +name: intestinal epithelial cell maturation +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus." [GOC:dph, PMID:18824147] +is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation +relationship: part_of GO:0060576 ! intestinal epithelial cell development + +[Term] +id: GO:0060575 +name: intestinal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine." [GOC:dph] +is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0060576 +name: intestinal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0002066 ! columnar/cuboidal epithelial cell development +relationship: part_of GO:0060575 ! intestinal epithelial cell differentiation + +[Term] +id: GO:0060577 +name: pulmonary vein morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart." [GOC:dph] +synonym: "pulmonary venous blood vessel morphogenesis" RELATED [GOC:dph] +is_a: GO:0048845 ! venous blood vessel morphogenesis + +[Term] +id: GO:0060578 +name: superior vena cava morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart." [GOC:dph] +is_a: GO:0048845 ! venous blood vessel morphogenesis + +[Term] +id: GO:0060579 +name: ventral spinal cord interneuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] +is_a: GO:0048663 ! neuron fate commitment +is_a: GO:0060581 ! cell fate commitment involved in pattern specification +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning +relationship: part_of GO:0021514 ! ventral spinal cord interneuron differentiation + +[Term] +id: GO:0060580 +name: ventral spinal cord interneuron fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses." [GOC:dph] +is_a: GO:0048664 ! neuron fate determination +is_a: GO:0060582 ! cell fate determination involved in pattern specification +relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment + +[Term] +id: GO:0060581 +name: cell fate commitment involved in pattern specification +namespace: biological_process +def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type." [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0007389 ! pattern specification process + +[Term] +id: GO:0060582 +name: cell fate determination involved in pattern specification +namespace: biological_process +def: "A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0060581 ! cell fate commitment involved in pattern specification + +[Term] +id: GO:0060583 +name: regulation of actin cortical patch localization +namespace: biological_process +def: "Any process that modulates the localization of an actin cortical patch. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:dph, GOC:tb] +synonym: "regulation of actin cortical patch localisation" EXACT [GOC:mah] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0051666 ! actin cortical patch localization + +[Term] +id: GO:0060584 +name: regulation of prostaglandin-endoperoxide synthase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "regulation of (PG)H synthase activity" RELATED [EC:1.14.99.1] +synonym: "regulation of fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1] +synonym: "regulation of PG synthetase activity" RELATED [EC:1.14.99.1] +synonym: "regulation of prostaglandin synthetase activity" RELATED [EC:1.14.99.1] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:0060585 +name: positive regulation of prostaglandin-endoperoxide synthase activity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of (PG)H synthase activity" RELATED [EC:1.14.99.1] +synonym: "positive regulation of fatty acid cyclooxygenase activity" RELATED [EC:1.14.99.1] +synonym: "positive regulation of PG synthetase activity" RELATED [EC:1.14.99.1] +synonym: "positive regulation of prostaglandin synthetase activity" RELATED [EC:1.14.99.1] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:0060584 ! regulation of prostaglandin-endoperoxide synthase activity + +[Term] +id: GO:0060586 +name: multicellular organismal iron ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism." [GOC:dph, GOC:hjd, GOC:tb] +is_a: GO:0048871 ! multicellular organismal homeostasis +is_a: GO:0055072 ! iron ion homeostasis + +[Term] +id: GO:0060587 +name: regulation of lipoprotein lipid oxidation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0034442 ! regulation of lipoprotein oxidation +relationship: regulates GO:0034439 ! lipoprotein lipid oxidation + +[Term] +id: GO:0060588 +name: negative regulation of lipoprotein lipid oxidation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of lipoprotein lipid oxidation. Lipoprotein lipid oxidation is the modification of a lipoprotein by oxidation of the lipid group." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0034443 ! negative regulation of lipoprotein oxidation +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0060587 ! regulation of lipoprotein lipid oxidation +relationship: negatively_regulates GO:0034439 ! lipoprotein lipid oxidation + +[Term] +id: GO:0060589 +name: nucleoside-triphosphatase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of an NTPase." [GOC:dph, GOC:tb] +synonym: "NTPase regulator activity" EXACT [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0060590 +name: ATPase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of an ATP hydrolysis activity." [GOC:dph, GOC:tb] +synonym: "ATP hydrolysis regulator activity" EXACT [] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0060591 +name: chondroblast differentiation +namespace: biological_process +def: "The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes." [GOC:dph] +synonym: "chondrocyte progenitor cell differentiation" RELATED [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0051216 ! cartilage development + +[Term] +id: GO:0060592 +name: mammary gland formation +namespace: biological_process +def: "The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme." [GOC:dph, PMID:16168142, PMID:17120154] +synonym: "mammary bud formation" RELATED [GOC:dph] +synonym: "mammary line formation" NARROW [GOC:dph] +synonym: "mammary placode formation" NARROW [GOC:dph] +synonym: "mammary sprout formation" RELATED [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060443 ! mammary gland morphogenesis + +[Term] +id: GO:0060593 +name: Wnt signaling pathway involved in mammary gland specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] +synonym: "Wnt receptor signaling pathway involved in mammary gland specification" EXACT [] +synonym: "Wnt receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in mammary gland specification" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0060594 ! mammary gland specification + +[Term] +id: GO:0060594 +name: mammary gland specification +namespace: biological_process +def: "The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph] +synonym: "mammary line specification" RELATED [GOC:dph] +is_a: GO:0010092 ! specification of animal organ identity +is_a: GO:0060592 ! mammary gland formation + +[Term] +id: GO:0060595 +name: fibroblast growth factor receptor signaling pathway involved in mammary gland specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of a fibroblast growth factor to its receptor on the surface of al cell in the epidermis resulting in the formation of the mammary line. The mammary line is a ridge of epidermal cells that will form the mammary placodes." [GOC:dph, PMID:16168142] +synonym: "fibroblast growth factor receptor signalling pathway involved in mammary gland specification" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0060594 ! mammary gland specification + +[Term] +id: GO:0060596 +name: mammary placode formation +namespace: biological_process +def: "The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper." [GOC:dph, PMID:16168142] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0060592 ! mammary gland formation + +[Term] +id: GO:0060597 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in mammary gland formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of the mammary line, placode or bud." [GOC:dph, PMID:16168142] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0030879 +consider: GO:0060592 + +[Term] +id: GO:0060598 +name: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis +namespace: biological_process +def: "The process in which the terminal end of a mammary duct bifurcates." [GOC:dph, PMID:17120154] +synonym: "primary mammary duct branching" EXACT [GOC:dph] +is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit +relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching + +[Term] +id: GO:0060599 +name: lateral sprouting involved in mammary gland duct morphogenesis +namespace: biological_process +def: "The process in which a branch forms along the side of a mammary duct." [GOC:dph, PMID:17120154] +synonym: "mammary gland duct secondary branching" EXACT [GOC:dph] +is_a: GO:0060601 ! lateral sprouting from an epithelium +relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis + +[Term] +id: GO:0060600 +name: dichotomous subdivision of an epithelial terminal unit +namespace: biological_process +def: "The process in which an epithelial cord, rod or tube bifurcates at its end." [GOC:dph] +synonym: "primary branching of an epithelium" RELATED [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium + +[Term] +id: GO:0060601 +name: lateral sprouting from an epithelium +namespace: biological_process +def: "The process in which a branch forms along the side of an epithelium." [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium + +[Term] +id: GO:0060602 +name: branch elongation of an epithelium +namespace: biological_process +def: "The growth process in which a branch increases in length from its base to its tip." [GOC:dph] +is_a: GO:0003401 ! axis elongation +relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium + +[Term] +id: GO:0060603 +name: mammary gland duct morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk." [GOC:dph, PMID:17120154] +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0060443 ! mammary gland morphogenesis +relationship: part_of GO:0061180 ! mammary gland epithelium development + +[Term] +id: GO:0060604 +name: mammary gland duct cavitation +namespace: biological_process +def: "Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod." [GOC:dph, PMID:17120154] +synonym: "milk duct cavitation" RELATED [GOC:dph] +is_a: GO:0060605 ! tube lumen cavitation +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060605 +name: tube lumen cavitation +namespace: biological_process +def: "The formation of a lumen by hollowing out a solid rod or cord." [GOC:dph] +is_a: GO:0035148 ! tube formation + +[Term] +id: GO:0060606 +name: tube closure +namespace: biological_process +def: "Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold." [GOC:dph] +is_a: GO:0035148 ! tube formation + +[Term] +id: GO:0060607 +name: cell-cell adhesion involved in sealing an epithelial fold +namespace: biological_process +def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube." [GOC:dph] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0060606 ! tube closure + +[Term] +id: GO:0060608 +name: cell-cell adhesion involved in neural tube closure +namespace: biological_process +def: "The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube." [GOC:dph] +is_a: GO:0060607 ! cell-cell adhesion involved in sealing an epithelial fold +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0060609 +name: apoptotic process involved in tube lumen cavitation +namespace: biological_process +def: "Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube." [GOC:dph, GOC:mtg_apoptosis] +synonym: "apoptosis involved in tube lumen cavitation" NARROW [] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +relationship: part_of GO:0060605 ! tube lumen cavitation + +[Term] +id: GO:0060610 +name: mesenchymal cell differentiation involved in mammary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mammary gland mesenchymal cell. Mammary gland mesenchymal cells form a loosely connected network of cells that surround the mammary ducts." [GOC:dph] +synonym: "mammary gland mesenchymal cell differentiation" EXACT [GOC:dph] +is_a: GO:0048762 ! mesenchymal cell differentiation +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060611 +name: mammary gland fat development +namespace: biological_process +def: "The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." [GOC:dph] +is_a: GO:0060612 ! adipose tissue development +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060612 +name: adipose tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat." [GOC:dph] +synonym: "adipogenesis" RELATED [GOC:mah, GOC:sl] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0060613 +name: fat pad development +namespace: biological_process +def: "The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue." [GOC:dph] +is_a: GO:0060612 ! adipose tissue development + +[Term] +id: GO:0060614 +name: negative regulation of mammary gland development in males by androgen receptor signaling pathway +namespace: biological_process +def: "Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." [GOC:dph] +synonym: "negative regulation of mammary gland development in males by androgen receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0030521 ! androgen receptor signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: negatively_regulates GO:0030879 ! mammary gland development + +[Term] +id: GO:0060615 +name: mammary gland bud formation +namespace: biological_process +def: "The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis." [GOC:dph, PMID:12558599] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060648 ! mammary gland bud morphogenesis + +[Term] +id: GO:0060616 +name: mammary gland cord formation +namespace: biological_process +def: "The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad." [GOC:dph, PMID:12558599] +synonym: "mammary gland sprout formation" EXACT [GOC:dph] +is_a: GO:0016331 ! morphogenesis of embryonic epithelium +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0060652 ! mammary gland cord morphogenesis + +[Term] +id: GO:0060617 +name: positive regulation of mammary placode formation by mesenchymal-epithelial signaling +namespace: biological_process +def: "Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode." [GOC:dph, PMID:12558599] +synonym: "positive regulation of mammary placode formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: positively_regulates GO:0060596 ! mammary placode formation + +[Term] +id: GO:0060618 +name: nipple development +namespace: biological_process +def: "The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060619 +name: cell migration involved in mammary placode formation +namespace: biological_process +def: "The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode." [GOC:dph, PMID:12558599] +is_a: GO:0010631 ! epithelial cell migration +relationship: part_of GO:0060596 ! mammary placode formation + +[Term] +id: GO:0060620 +name: regulation of cholesterol import +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032374 ! regulation of cholesterol transport +is_a: GO:2000909 ! regulation of sterol import +relationship: regulates GO:0070508 ! cholesterol import + +[Term] +id: GO:0060621 +name: negative regulation of cholesterol import +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032375 ! negative regulation of cholesterol transport +is_a: GO:0060620 ! regulation of cholesterol import +is_a: GO:2000910 ! negative regulation of sterol import +relationship: negatively_regulates GO:0070508 ! cholesterol import + +[Term] +id: GO:0060622 +name: regulation of ascospore wall beta-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of ascospore wall beta-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0090093 ! regulation of fungal-type cell wall beta-glucan biosynthetic process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0034412 ! ascospore wall beta-glucan biosynthetic process + +[Term] +id: GO:0060623 +name: regulation of chromosome condensation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:dph, GOC:tb] +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0030261 ! chromosome condensation + +[Term] +id: GO:0060624 +name: regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process, the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D--glucosidic bonds, found in the walls of ascospores." [GOC:dph, GOC:tb] +synonym: "regulation of ascospore wall 1,3-beta-D-glucan biosynthetic process" BROAD [] +synonym: "regulation of ascospore wall 1,3-beta-glucan biosynthetic process" BROAD [] +is_a: GO:0060622 ! regulation of ascospore wall beta-glucan biosynthetic process +is_a: GO:0090334 ! regulation of cell wall (1->3)-beta-D-glucan biosynthetic process +relationship: regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0060625 +name: regulation of protein deneddylation +namespace: biological_process +alt_id: GO:0060626 +def: "Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:dph, GOC:tb] +synonym: "regulation of cullin deneddylation" NARROW [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0000338 ! protein deneddylation + +[Term] +id: GO:0060627 +name: regulation of vesicle-mediated transport +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell." [GOC:dph, GOC:tb] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0060628 +name: regulation of ER to Golgi vesicle-mediated transport +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:dph, GOC:tb] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:0060629 +name: regulation of homologous chromosome segregation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of homologous chromosome segregation, the cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051983 ! regulation of chromosome segregation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0060630 +name: obsolete regulation of M/G1 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of M/G1 transition of the mitotic cell cycle, the progression from M phase to G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "regulation of M/G1 transition of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0060631 +name: regulation of meiosis I +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] +is_a: GO:0040020 ! regulation of meiotic nuclear division +relationship: regulates GO:0007127 ! meiosis I + +[Term] +id: GO:0060632 +name: regulation of microtubule-based movement +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [GOC:dph, GOC:tb] +is_a: GO:0032886 ! regulation of microtubule-based process +is_a: GO:0051270 ! regulation of cellular component movement +relationship: regulates GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0060633 +name: negative regulation of transcription initiation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter." [GOC:dph, GOC:tb, GOC:txnOH] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter +is_a: GO:2000143 ! negative regulation of DNA-templated transcription, initiation +relationship: negatively_regulates GO:0006367 ! transcription initiation from RNA polymerase II promoter + +[Term] +id: GO:0060634 +name: regulation of 4,6-pyruvylated galactose residue biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of 4,6-pyruvylated galactose residue biosynthetic process, the chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-(1->3)-. The galactose residue is part of a larger polysaccharide chain." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0051072 ! 4,6-pyruvylated galactose residue biosynthetic process + +[Term] +id: GO:0060635 +name: positive regulation of (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb] +synonym: "positive regulation of 1,3-beta-D-glucan biosynthetic process" EXACT [] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process +relationship: positively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0060636 +name: negative regulation of (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:dph, GOC:tb] +synonym: "negative regulation of 1,3-beta-D-glucan biosynthetic process" EXACT [] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0060637 +name: positive regulation of lactation by mesenchymal-epithelial cell signaling +namespace: biological_process +def: "The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell." [GOC:dph, PMID:12558599] +synonym: "positive regulation of lactation by mesenchymal-epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling +is_a: GO:1903489 ! positive regulation of lactation + +[Term] +id: GO:0060638 +name: mesenchymal-epithelial cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted." [GOC:dph] +synonym: "mesenchymal-epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0060639 +name: positive regulation of salivary gland formation by mesenchymal-epithelial signaling +namespace: biological_process +def: "Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell." [GOC:dph] +synonym: "positive regulation of salivary gland formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: positively_regulates GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0060640 +name: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling +namespace: biological_process +def: "Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." [GOC:dph] +synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling" RELATED [] +synonym: "positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling" EXACT [GOC:mah] +is_a: GO:0042488 ! positive regulation of odontogenesis of dentin-containing tooth +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling + +[Term] +id: GO:0060641 +name: mammary gland duct regression in males +namespace: biological_process +def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060642 +name: white fat cell differentiation involved in mammary gland fat development +namespace: biological_process +def: "The process in which a preadipocyte acquires specialized features of a white adipocyte of the mammary gland. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [GOC:dph, PMID:12558599] +is_a: GO:0050872 ! white fat cell differentiation +relationship: part_of GO:0060611 ! mammary gland fat development + +[Term] +id: GO:0060643 +name: epithelial cell differentiation involved in mammary gland bud morphogenesis +namespace: biological_process +def: "The process in which a cell of the mammary placode becomes a cell of the mammary gland bud." [GOC:dph] +is_a: GO:0060644 ! mammary gland epithelial cell differentiation +relationship: part_of GO:0060615 ! mammary gland bud formation + +[Term] +id: GO:0060644 +name: mammary gland epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland." [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0061180 ! mammary gland epithelium development + +[Term] +id: GO:0060645 +name: peripheral mammary gland bud epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically." [GOC:dph, PMID:12558599] +is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis + +[Term] +id: GO:0060646 +name: internal mammary gland bud epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape." [GOC:dph, PMID:12558599] +is_a: GO:0060643 ! epithelial cell differentiation involved in mammary gland bud morphogenesis + +[Term] +id: GO:0060647 +name: mesenchymal cell condensation involved in mammary fat development +namespace: biological_process +def: "The cell adhesion process in which mammary mesenchyme cells adhere to one another in the initial stages of the formation of mammary fat development." [GOC:dph, PMID:12558599] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0060611 ! mammary gland fat development + +[Term] +id: GO:0060648 +name: mammary gland bud morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord." [GOC:dph, PMID:12558599] +is_a: GO:0060572 ! morphogenesis of an epithelial bud +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060649 +name: mammary gland bud elongation +namespace: biological_process +def: "The process in which the mammary gland bud grows along its axis." [GOC:dph, PMID:12558599] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0060648 ! mammary gland bud morphogenesis + +[Term] +id: GO:0060650 +name: epithelial cell proliferation involved in mammary gland bud elongation +namespace: biological_process +def: "The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud." [GOC:dph, PMID:12558599] +is_a: GO:0033598 ! mammary gland epithelial cell proliferation +relationship: part_of GO:0060649 ! mammary gland bud elongation + +[Term] +id: GO:0060651 +name: regulation of epithelial cell proliferation involved in mammary gland bud elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud." [GOC:dph, PMID:12558599] +is_a: GO:0033599 ! regulation of mammary gland epithelial cell proliferation +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0060650 ! epithelial cell proliferation involved in mammary gland bud elongation + +[Term] +id: GO:0060652 +name: mammary gland cord morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat." [GOC:dph, PMID:12558599] +synonym: "mammary gland sprout morphogenesis" EXACT [GOC:dph] +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060653 +name: epithelial cell differentiation involved in mammary gland cord morphogenesis +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified." [GOC:dph, PMID:12558599] +synonym: "epithelial cell differentiation involved in mammary gland sprout morphogenesis" RELATED [GOC:dph] +is_a: GO:0060644 ! mammary gland epithelial cell differentiation +relationship: part_of GO:0060652 ! mammary gland cord morphogenesis + +[Term] +id: GO:0060654 +name: mammary gland cord elongation +namespace: biological_process +def: "The process in which the mammary gland sprout grows along its axis." [GOC:dph, PMID:12558599] +is_a: GO:0060751 ! branch elongation involved in mammary gland duct branching +relationship: part_of GO:0060652 ! mammary gland cord morphogenesis + +[Term] +id: GO:0060655 +name: branching involved in mammary gland cord morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct." [GOC:dph, PMID:12558599] +is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis +relationship: part_of GO:0060652 ! mammary gland cord morphogenesis + +[Term] +id: GO:0060656 +name: regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell." [GOC:dph, PMID:12558599] +synonym: "regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0060762 ! regulation of branching involved in mammary gland duct morphogenesis +relationship: regulates GO:0060655 ! branching involved in mammary gland cord morphogenesis + +[Term] +id: GO:0060657 +name: regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell." [GOC:dph, PMID:12558599] +synonym: "regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: regulates GO:0060654 ! mammary gland cord elongation + +[Term] +id: GO:0060658 +name: nipple morphogenesis +namespace: biological_process +def: "The process in which the nipple is generated and organized." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060618 ! nipple development + +[Term] +id: GO:0060659 +name: nipple sheath formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate." [GOC:dph, PMID:12558599] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060658 ! nipple morphogenesis + +[Term] +id: GO:0060660 +name: epidermis morphogenesis involved in nipple formation +namespace: biological_process +def: "The process in which the epidermis of the nipple sheath is uplifted to form an umbrella-like projection." [GOC:dph, PMID:12558599] +is_a: GO:0048730 ! epidermis morphogenesis +relationship: part_of GO:0060658 ! nipple morphogenesis + +[Term] +id: GO:0060661 +name: submandibular salivary gland formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed." [GOC:dph, PMID:17336109] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0060662 +name: salivary gland cavitation +namespace: biological_process +def: "The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland." [GOC:dph] +synonym: "salivary gland invagination" EXACT [] +is_a: GO:0060605 ! tube lumen cavitation +relationship: part_of GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0060663 +name: apoptotic process involved in salivary gland cavitation +namespace: biological_process +def: "Any apoptotic process in which the solid core of the gland is hollowed out to form the duct." [GOC:dph, GOC:mtg_apoptosis, PMID:17336109] +synonym: "apoptosis involved in salivary gland cavitation" NARROW [] +is_a: GO:0060609 ! apoptotic process involved in tube lumen cavitation +relationship: part_of GO:0060662 ! salivary gland cavitation + +[Term] +id: GO:0060664 +name: epithelial cell proliferation involved in salivary gland morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells of the submandibular salivary gland, resulting in the expansion of a cell population and the shaping of the gland." [GOC:dph, PMID:17336109] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0007435 ! salivary gland morphogenesis + +[Term] +id: GO:0060665 +name: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." [GOC:dph, PMID:17336109] +synonym: "regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling" EXACT [GOC:mah] +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling +is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060666 +name: dichotomous subdivision of terminal units involved in salivary gland branching +namespace: biological_process +def: "The process in which a salivary epithelial cord bifurcates at its end." [GOC:dph] +is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit +relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060667 +name: branch elongation involved in salivary gland morphogenesis +namespace: biological_process +def: "The differential growth of the salivary branches along their axis, resulting in the growth of a branch." [GOC:dph] +is_a: GO:0060602 ! branch elongation of an epithelium +relationship: part_of GO:0060445 ! branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060668 +name: regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland." [GOC:dph] +synonym: "regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling" EXACT [GOC:mah] +is_a: GO:0035426 ! extracellular matrix-cell signaling +is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060669 +name: embryonic placenta morphogenesis +namespace: biological_process +def: "The process in which the embryonic placenta is generated and organized." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060670 +name: branching involved in labyrinthine layer morphogenesis +namespace: biological_process +def: "The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer." [GOC:dph, PMID:16916377] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0061138 ! morphogenesis of a branching epithelium +relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis + +[Term] +id: GO:0060671 +name: epithelial cell differentiation involved in embryonic placenta development +namespace: biological_process +def: "The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer." [GOC:dph, PMID:16916377] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development +relationship: part_of GO:0060711 ! labyrinthine layer development + +[Term] +id: GO:0060672 +name: epithelial cell morphogenesis involved in placental branching +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:16916377] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0003382 ! epithelial cell morphogenesis +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060670 ! branching involved in labyrinthine layer morphogenesis +relationship: part_of GO:0060671 ! epithelial cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060673 +name: cell-cell signaling involved in placenta development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another." [GOC:dph, PMID:16916377] +synonym: "cell-cell signalling involved in placenta development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060674 +name: placenta blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure." [GOC:dph, PMID:16916377] +is_a: GO:0001568 ! blood vessel development +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0001890 ! placenta development + +[Term] +id: GO:0060675 +name: ureteric bud morphogenesis +namespace: biological_process +def: "The process in which the ureteric bud is generated and organized." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0072171 ! mesonephric tubule morphogenesis +relationship: part_of GO:0001657 ! ureteric bud development + +[Term] +id: GO:0060676 +name: ureteric bud formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud." [GOC:dph, PMID:16916378] +is_a: GO:0072172 ! mesonephric tubule formation +relationship: part_of GO:0060675 ! ureteric bud morphogenesis + +[Term] +id: GO:0060677 +name: ureteric bud elongation +namespace: biological_process +def: "The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated." [GOC:dph, PMID:16916378] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0060675 ! ureteric bud morphogenesis + +[Term] +id: GO:0060678 +name: dichotomous subdivision of terminal units involved in ureteric bud branching +namespace: biological_process +def: "The process in which a ureteric bud bifurcates at its end." [GOC:dph, PMID:16916378] +synonym: "bifid subdivision of terminal units involved in ureteric bud branching" EXACT [GOC:dph, PMID:16916378] +is_a: GO:0060600 ! dichotomous subdivision of an epithelial terminal unit +relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0060679 +name: trifid subdivision of terminal units involved in ureteric bud branching +namespace: biological_process +def: "The process in which a ureteric bud splits into three units at its end." [GOC:dph, PMID:16916378] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0060680 +name: lateral sprouting involved in ureteric bud morphogenesis +namespace: biological_process +def: "The process in which a branch forms along the side of a ureteric bud." [GOC:dph, PMID:16916378] +is_a: GO:0060601 ! lateral sprouting from an epithelium +relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0060681 +name: branch elongation involved in ureteric bud branching +namespace: biological_process +def: "The growth of a branch of the ureteric bud along its axis." [GOC:dph, PMID:16916378] +is_a: GO:0060602 ! branch elongation of an epithelium +relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis +relationship: part_of GO:0060677 ! ureteric bud elongation + +[Term] +id: GO:0060682 +name: primary ureteric bud growth +namespace: biological_process +def: "The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema." [GOC:dph, PMID:16916378] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0060677 ! ureteric bud elongation + +[Term] +id: GO:0060683 +name: regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland." [GOC:dph, PMID:18559345] +synonym: "regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling" EXACT [GOC:mah] +is_a: GO:0060684 ! epithelial-mesenchymal cell signaling +is_a: GO:0060693 ! regulation of branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060684 +name: epithelial-mesenchymal cell signaling +namespace: biological_process +def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted." [GOC:dph] +synonym: "epithelial-mesenchymal cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0060685 +name: regulation of prostatic bud formation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] +is_a: GO:0003156 ! regulation of animal organ formation +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060513 ! prostatic bud formation + +[Term] +id: GO:0060686 +name: negative regulation of prostatic bud formation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." [GOC:dph] +is_a: GO:0060685 ! regulation of prostatic bud formation +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060513 ! prostatic bud formation + +[Term] +id: GO:0060687 +name: regulation of branching involved in prostate gland morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of prostate gland branching, the process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060442 ! branching involved in prostate gland morphogenesis + +[Term] +id: GO:0060688 +name: regulation of morphogenesis of a branching structure +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized." [GOC:dph] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0001763 ! morphogenesis of a branching structure + +[Term] +id: GO:0060689 +name: cell differentiation involved in salivary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland." [GOC:dph] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0007431 ! salivary gland development + +[Term] +id: GO:0060690 +name: epithelial cell differentiation involved in salivary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland." [GOC:dph] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0060689 ! cell differentiation involved in salivary gland development + +[Term] +id: GO:0060691 +name: epithelial cell maturation involved in salivary gland development +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state." [GOC:dph] +is_a: GO:0002070 ! epithelial cell maturation +relationship: part_of GO:0060690 ! epithelial cell differentiation involved in salivary gland development + +[Term] +id: GO:0060692 +name: mesenchymal cell differentiation involved in salivary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the salivary gland. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] +is_a: GO:0048762 ! mesenchymal cell differentiation +is_a: GO:0060689 ! cell differentiation involved in salivary gland development + +[Term] +id: GO:0060693 +name: regulation of branching involved in salivary gland morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium." [GOC:dph] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0060445 ! branching involved in salivary gland morphogenesis + +[Term] +id: GO:0060694 +name: regulation of cholesterol transporter activity +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0110112 ! regulation of lipid transporter activity + +[Term] +id: GO:0060695 +name: negative regulation of cholesterol transporter activity +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of cholesterol transporter activity." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0060694 ! regulation of cholesterol transporter activity +is_a: GO:0110114 ! negative regulation of lipid transporter activity + +[Term] +id: GO:0060696 +name: regulation of phospholipid catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0009395 ! phospholipid catabolic process + +[Term] +id: GO:0060697 +name: positive regulation of phospholipid catabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of phospholipid catabolism, the chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:0060696 ! regulation of phospholipid catabolic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0009395 ! phospholipid catabolic process + +[Term] +id: GO:0060698 +name: endoribonuclease inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of endoribonuclease." [GOC:dph, GOC:tb] +is_a: GO:0008428 ! ribonuclease inhibitor activity + +[Term] +id: GO:0060699 +name: regulation of endoribonuclease activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] +is_a: GO:0060700 ! regulation of ribonuclease activity + +[Term] +id: GO:0060700 +name: regulation of ribonuclease activity +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] +is_a: GO:0032069 ! regulation of nuclease activity +is_a: GO:0051252 ! regulation of RNA metabolic process + +[Term] +id: GO:0060701 +name: negative regulation of ribonuclease activity +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:dph, GOC:tb] +is_a: GO:0032074 ! negative regulation of nuclease activity +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:0060700 ! regulation of ribonuclease activity + +[Term] +id: GO:0060702 +name: negative regulation of endoribonuclease activity +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:dph, GOC:tb] +is_a: GO:0060699 ! regulation of endoribonuclease activity +is_a: GO:0060701 ! negative regulation of ribonuclease activity + +[Term] +id: GO:0060703 +name: deoxyribonuclease inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of deoxyribonuclease." [GOC:dph, GOC:tb] +synonym: "DNase inhibitor activity" RELATED [GOC:dph, GOC:tb] +is_a: GO:0140721 ! nuclease inhibitor activity + +[Term] +id: GO:0060704 +name: acinar cell differentiation involved in salivary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize an acinar cell of the salivary gland. Acinar cells are protein-secreting cells in the gland." [GOC:dph, GOC:tb] +is_a: GO:0060690 ! epithelial cell differentiation involved in salivary gland development +is_a: GO:0090425 ! acinar cell differentiation + +[Term] +id: GO:0060705 +name: neuron differentiation involved in salivary gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the neurons of the salivary gland." [GOC:dph] +is_a: GO:0030182 ! neuron differentiation +is_a: GO:0060689 ! cell differentiation involved in salivary gland development + +[Term] +id: GO:0060706 +name: cell differentiation involved in embryonic placenta development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060707 +name: trophoblast giant cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua." [GOC:dph, PMID:16269175] +is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060708 +name: spongiotrophoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell." [GOC:dph, PMID:16269175] +synonym: "spongiotrophoblast cell differentiation" EXACT [GOC:cjm] +is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development +relationship: part_of GO:0060712 ! spongiotrophoblast layer development + +[Term] +id: GO:0060709 +name: glycogen cell differentiation involved in embryonic placenta development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer." [GOC:dph, PMID:16269175] +is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development +relationship: part_of GO:0060712 ! spongiotrophoblast layer development + +[Term] +id: GO:0060710 +name: chorio-allantoic fusion +namespace: biological_process +def: "The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois." [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis + +[Term] +id: GO:0060711 +name: labyrinthine layer development +namespace: biological_process +def: "The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state." [GOC:dph] +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060712 +name: spongiotrophoblast layer development +namespace: biological_process +def: "The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state." [GOC:dph] +is_a: GO:0009888 ! tissue development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060713 +name: labyrinthine layer morphogenesis +namespace: biological_process +def: "The process in which the labyrinthine layer of the placenta is generated and organized." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060669 ! embryonic placenta morphogenesis +relationship: part_of GO:0060711 ! labyrinthine layer development + +[Term] +id: GO:0060714 +name: labyrinthine layer formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060713 ! labyrinthine layer morphogenesis + +[Term] +id: GO:0060715 +name: syncytiotrophoblast cell differentiation involved in labyrinthine layer development +namespace: biological_process +def: "The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta." [GOC:dph] +is_a: GO:0060706 ! cell differentiation involved in embryonic placenta development +relationship: part_of GO:0060711 ! labyrinthine layer development + +[Term] +id: GO:0060716 +name: labyrinthine layer blood vessel development +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply." [GOC:dph] +is_a: GO:0048568 ! embryonic organ development +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0060674 ! placenta blood vessel development +relationship: part_of GO:0060711 ! labyrinthine layer development + +[Term] +id: GO:0060717 +name: chorion development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane." [GOC:dph] +is_a: GO:1903867 ! extraembryonic membrane development + +[Term] +id: GO:0060718 +name: chorionic trophoblast cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer." [CL:0011101, GOC:dph, PMID:16983341] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0060717 ! chorion development + +[Term] +id: GO:0060719 +name: chorionic trophoblast cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [CL:0011101, GOC:16983341, GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060718 ! chorionic trophoblast cell differentiation + +[Term] +id: GO:0060720 +name: spongiotrophoblast cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer." [GOC:dph] +is_a: GO:0060722 ! cell proliferation involved in embryonic placenta development +relationship: part_of GO:0090214 ! spongiotrophoblast layer developmental growth + +[Term] +id: GO:0060721 +name: regulation of spongiotrophoblast cell proliferation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of spongiotrophoblast cell proliferation." [GOC:dph] +is_a: GO:0060723 ! regulation of cell proliferation involved in embryonic placenta development +relationship: regulates GO:0060720 ! spongiotrophoblast cell proliferation + +[Term] +id: GO:0060722 +name: cell proliferation involved in embryonic placenta development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta." [GOC:dph] +is_a: GO:0008283 ! cell population proliferation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0001892 ! embryonic placenta development + +[Term] +id: GO:0060723 +name: regulation of cell proliferation involved in embryonic placenta development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development." [GOC:dph] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060722 ! cell proliferation involved in embryonic placenta development + +[Term] +id: GO:0060724 +name: coreceptor activity involved in epidermal growth factor receptor signaling pathway +namespace: molecular_function +def: "Combining with an extracellular messenger, and in cooperation with a primary EGF receptor, initiating a change in cell activity through the EGF receptor signaling pathway." [GOC:dph, GOC:tb] +synonym: "coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0015026 ! coreceptor activity + +[Term] +id: GO:0060725 +name: regulation of coreceptor activity +namespace: biological_process +def: "Any process that modulates the rate or frequency of coreceptor activity, combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:dph, GOC:tb] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:0060726 +name: regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] +synonym: "regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] +is_a: GO:0060725 ! regulation of coreceptor activity + +[Term] +id: GO:0060727 +name: positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] +synonym: "positive regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] +is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0060728 +name: negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway." [GOC:dph, GOC:tb] +synonym: "negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of Neu/ErbB-2 receptor activity" NARROW [GOC:dph, GOC:tb] +is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0060726 ! regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0060729 +name: intestinal epithelial structure maintenance +namespace: biological_process +def: "A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "epithelial structure maintenance of intestine" EXACT [GOC:dph, GOC:tb] +synonym: "maintenance of intestinal epithelium" EXACT [GOC:dph, GOC:tb] +is_a: GO:0030277 ! maintenance of gastrointestinal epithelium + +[Term] +id: GO:0060730 +name: regulation of intestinal epithelial structure maintenance +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0060729 ! intestinal epithelial structure maintenance + +[Term] +id: GO:0060731 +name: positive regulation of intestinal epithelial structure maintenance +namespace: biological_process +def: "Any process the increases the rate, frequency or extent of intestinal epithelial structure maintenance, a tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium." [GOC:dph, GOC:tb] +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:0060730 ! regulation of intestinal epithelial structure maintenance +relationship: positively_regulates GO:0060729 ! intestinal epithelial structure maintenance + +[Term] +id: GO:0060732 +name: positive regulation of inositol phosphate biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0032958 ! inositol phosphate biosynthetic process + +[Term] +id: GO:0060734 +name: regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress." [GOC:dph, GOC:tb] +synonym: "regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress" EXACT [] +synonym: "regulation of eIF2 alpha phosphorylation by ER stress" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +relationship: regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress + +[Term] +id: GO:0060735 +name: regulation of eIF2 alpha phosphorylation by dsRNA +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA." [GOC:dph, GOC:tb] +synonym: "regulation of eIF2 alpha phosphorylation by double-stranded RNA" EXACT [GOC:dph] +synonym: "regulation of eIF2 alpha phosphorylation by PKR" NARROW [GOC:dph, GOC:tb] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: part_of GO:0071359 ! cellular response to dsRNA +relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation + +[Term] +id: GO:0060736 +name: prostate gland growth +namespace: biological_process +def: "The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0035265 ! organ growth +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060737 +name: prostate gland morphogenetic growth +namespace: biological_process +def: "The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form." [GOC:dph] +synonym: "prostate gland growth involved in morphogenesis" EXACT [GOC:dph] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +is_a: GO:0060736 ! prostate gland growth +relationship: part_of GO:0060512 ! prostate gland morphogenesis + +[Term] +id: GO:0060738 +name: epithelial-mesenchymal signaling involved in prostate gland development +namespace: biological_process +def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time." [GOC:dph] +synonym: "epithelial-mesenchymal signalling involved in prostate gland development" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0060684 ! epithelial-mesenchymal cell signaling +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060739 +name: mesenchymal-epithelial cell signaling involved in prostate gland development +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time." [GOC:dph] +synonym: "mesenchymal-epithelial cell signalling involved in prostate gland development" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0060638 ! mesenchymal-epithelial cell signaling +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060740 +name: prostate gland epithelium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0060512 ! prostate gland morphogenesis + +[Term] +id: GO:0060741 +name: prostate gland stromal morphogenesis +namespace: biological_process +def: "The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060512 ! prostate gland morphogenesis +relationship: part_of GO:0061448 ! connective tissue development + +[Term] +id: GO:0060742 +name: epithelial cell differentiation involved in prostate gland development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060743 +name: epithelial cell maturation involved in prostate gland development +namespace: biological_process +def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] +synonym: "prostate gland epithelial cell development" EXACT [GOC:dph] +is_a: GO:0002070 ! epithelial cell maturation +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0060742 ! epithelial cell differentiation involved in prostate gland development + +[Term] +id: GO:0060744 +name: mammary gland branching involved in thelarche +namespace: biological_process +def: "The process in which the branching structure of the mammary gland duct is generated and organized during the period of sexual maturity in mammals. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, PMID:19261859] +synonym: "mammary gland branching involved in puberty" RELATED [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis +relationship: part_of GO:0042695 ! thelarche + +[Term] +id: GO:0060745 +name: mammary gland branching involved in pregnancy +namespace: biological_process +def: "The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy." [GOC:dph, PMID:19261859] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0060135 ! maternal process involved in female pregnancy +is_a: GO:0060444 ! branching involved in mammary gland duct morphogenesis + +[Term] +id: GO:0060746 +name: parental behavior +namespace: biological_process +def: "A reproductive behavior in which a parent cares for and rears offspring." [GOC:dph] +is_a: GO:0019098 ! reproductive behavior + +[Term] +id: GO:0060747 +name: oral incubation +namespace: biological_process +def: "A parental behavior in which fertilized eggs are taken into the mouth and held until hatching." [GOC:dph] +is_a: GO:0060746 ! parental behavior + +[Term] +id: GO:0060748 +name: tertiary branching involved in mammary gland duct morphogenesis +namespace: biological_process +def: "The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy." [GOC:dph, PMID:18614704] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0060745 ! mammary gland branching involved in pregnancy + +[Term] +id: GO:0060749 +name: mammary gland alveolus development +namespace: biological_process +def: "The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061377 ! mammary gland lobule development + +[Term] +id: GO:0060750 +name: epithelial cell proliferation involved in mammary gland duct elongation +namespace: biological_process +def: "The multiplication or reproduction of mammary gland branch epithelial cells, resulting in the elongation of the branch. The mammary gland branch differs from the bud in that it is not the initial curved portion of the outgrowth." [GOC:dph] +is_a: GO:0033598 ! mammary gland epithelial cell proliferation +relationship: part_of GO:0060751 ! branch elongation involved in mammary gland duct branching + +[Term] +id: GO:0060751 +name: branch elongation involved in mammary gland duct branching +namespace: biological_process +def: "The developmental growth process in which a branch of a mammary gland duct elongates." [GOC:dph] +synonym: "mammary gland duct branch elongation" EXACT [GOC:dph] +is_a: GO:0060602 ! branch elongation of an epithelium +relationship: part_of GO:0060444 ! branching involved in mammary gland duct morphogenesis + +[Term] +id: GO:0060752 +name: intestinal phytosterol absorption +namespace: biological_process +def: "Any process in which phytosterols are taken up from the contents of the intestine." [GOC:dph, GOC:tb] +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0098856 ! intestinal lipid absorption + +[Term] +id: GO:0060753 +name: regulation of mast cell chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +relationship: regulates GO:0002551 ! mast cell chemotaxis + +[Term] +id: GO:0060754 +name: positive regulation of mast cell chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0060753 ! regulation of mast cell chemotaxis +relationship: positively_regulates GO:0002551 ! mast cell chemotaxis + +[Term] +id: GO:0060755 +name: negative regulation of mast cell chemotaxis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus." [GOC:dph, GOC:tb] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0060753 ! regulation of mast cell chemotaxis +relationship: negatively_regulates GO:0002551 ! mast cell chemotaxis + +[Term] +id: GO:0060756 +name: foraging behavior +namespace: biological_process +def: "Behavior by which an organism locates food." [GOC:dph, GOC:tb] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0060757 +name: adult foraging behavior +namespace: biological_process +def: "Behavior by which an adult locates food." [GOC:dph, GOC:tb] +is_a: GO:0060756 ! foraging behavior + +[Term] +id: GO:0060758 +name: foraging behavior by probing substrate +namespace: biological_process +def: "Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food." [GOC:dph, GOC:tb] +is_a: GO:0060756 ! foraging behavior + +[Term] +id: GO:0060759 +name: regulation of response to cytokine stimulus +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0034097 ! response to cytokine + +[Term] +id: GO:0060760 +name: positive regulation of response to cytokine stimulus +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0060759 ! regulation of response to cytokine stimulus +relationship: positively_regulates GO:0034097 ! response to cytokine + +[Term] +id: GO:0060761 +name: negative regulation of response to cytokine stimulus +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0060759 ! regulation of response to cytokine stimulus +relationship: negatively_regulates GO:0034097 ! response to cytokine + +[Term] +id: GO:0060762 +name: regulation of branching involved in mammary gland duct morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis." [GOC:dph] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0060444 ! branching involved in mammary gland duct morphogenesis + +[Term] +id: GO:0060763 +name: mammary duct terminal end bud growth +namespace: biological_process +def: "The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty." [GOC:dph, PMID:10804170] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0060603 ! mammary gland duct morphogenesis + +[Term] +id: GO:0060764 +name: cell-cell signaling involved in mammary gland development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure." [GOC:dph] +synonym: "cell-cell signalling involved in mammary gland development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0060765 +name: regulation of androgen receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] +synonym: "regulation of androgen receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +relationship: regulates GO:0030521 ! androgen receptor signaling pathway + +[Term] +id: GO:0060766 +name: negative regulation of androgen receptor signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway." [GOC:dph] +synonym: "negative regulation of androgen receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:0060765 ! regulation of androgen receptor signaling pathway +relationship: negatively_regulates GO:0030521 ! androgen receptor signaling pathway + +[Term] +id: GO:0060767 +name: epithelial cell proliferation involved in prostate gland development +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph] +is_a: GO:0022414 ! reproductive process +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060768 +name: regulation of epithelial cell proliferation involved in prostate gland development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development + +[Term] +id: GO:0060769 +name: positive regulation of epithelial cell proliferation involved in prostate gland development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development + +[Term] +id: GO:0060770 +name: negative regulation of epithelial cell proliferation involved in prostate gland development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time." [GOC:dph] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060768 ! regulation of epithelial cell proliferation involved in prostate gland development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060767 ! epithelial cell proliferation involved in prostate gland development + +[Term] +id: GO:0060771 +name: phyllotactic patterning +namespace: biological_process +def: "The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009956 ! radial pattern formation + +[Term] +id: GO:0060772 +name: leaf phyllotactic patterning +namespace: biological_process +def: "The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060771 ! phyllotactic patterning + +[Term] +id: GO:0060773 +name: flower phyllotactic patterning +namespace: biological_process +def: "The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060771 ! phyllotactic patterning + +[Term] +id: GO:0060774 +name: auxin mediated signaling pathway involved in phyllotactic patterning +namespace: biological_process +def: "The series of molecular signals generated in response to detection of auxin that contributes to the radial pattern formation process resulting in the formation of leaf or flower primordia around the center of a shoot apical meristem." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "auxin mediated signalling pathway involved in phyllotactic patterning" EXACT [GOC:mah] +is_a: GO:0009734 ! auxin-activated signaling pathway +relationship: part_of GO:0060771 ! phyllotactic patterning + +[Term] +id: GO:0060775 +name: planar cell polarity pathway involved in gastrula mediolateral intercalation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +relationship: part_of GO:0060031 ! mediolateral intercalation + +[Term] +id: GO:0060776 +name: simple leaf morphogenesis +namespace: biological_process +def: "The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0060777 +name: compound leaf morphogenesis +namespace: biological_process +def: "The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:0060778 +name: primary leaflet morphogenesis +namespace: biological_process +def: "The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060794 ! leaflet morphogenesis + +[Term] +id: GO:0060779 +name: secondary leaflet morphogenesis +namespace: biological_process +def: "The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060794 ! leaflet morphogenesis + +[Term] +id: GO:0060780 +name: intercalary leaflet morphogenesis +namespace: biological_process +def: "The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060794 ! leaflet morphogenesis + +[Term] +id: GO:0060781 +name: mesenchymal cell proliferation involved in prostate gland development +namespace: biological_process +def: "The multiplication or reproduction of mesenchymal cells, resulting in the expansion of a cell population that contributes to the progression of the prostate gland over time." [GOC:dph, PMID:12221011] +is_a: GO:0010463 ! mesenchymal cell proliferation +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0030850 ! prostate gland development + +[Term] +id: GO:0060782 +name: regulation of mesenchymal cell proliferation involved in prostate gland development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the prostate gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, PMID:12221011] +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060781 ! mesenchymal cell proliferation involved in prostate gland development + +[Term] +id: GO:0060783 +name: mesenchymal smoothened signaling pathway involved in prostate gland development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development." [PMID:12221011] +synonym: "mesenchymal hedgehog signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] +synonym: "mesenchymal hh signaling pathway involved in prostate gland development" EXACT [GOC:bf, GOC:ecd] +synonym: "mesenchymal smoothened signalling pathway involved in prostate gland development" EXACT [GOC:mah] +is_a: GO:0007224 ! smoothened signaling pathway +is_a: GO:0022414 ! reproductive process +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0060738 ! epithelial-mesenchymal signaling involved in prostate gland development + +[Term] +id: GO:0060784 +name: regulation of cell proliferation involved in tissue homeostasis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue." [GOC:dph] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0060785 +name: regulation of apoptosis involved in tissue homeostasis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue." [GOC:dph] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0060786 +name: regulation of cell differentiation involved in tissue homeostasis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue." [GOC:dph] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: part_of GO:0048873 ! homeostasis of number of cells within a tissue + +[Term] +id: GO:0060787 +name: positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "positive regulation of posterior neural plate formation by FGF receptor signaling pathway" RELATED [GOC:dph, GOC:tb] +synonym: "positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: positively_regulates GO:0090018 ! posterior neural plate formation + +[Term] +id: GO:0060788 +name: ectodermal placode formation +namespace: biological_process +def: "The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0071697 ! ectodermal placode morphogenesis + +[Term] +id: GO:0060789 +name: hair follicle placode formation +namespace: biological_process +def: "The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0001942 ! hair follicle development + +[Term] +id: GO:0060790 +name: tooth placode formation +namespace: biological_process +def: "The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth + +[Term] +id: GO:0060791 +name: sebaceous gland placode formation +namespace: biological_process +def: "The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0048733 ! sebaceous gland development + +[Term] +id: GO:0060792 +name: sweat gland development +namespace: biological_process +def: "The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0060793 +name: sweat gland placode formation +namespace: biological_process +def: "The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060788 ! ectodermal placode formation +relationship: part_of GO:0060792 ! sweat gland development + +[Term] +id: GO:0060794 +name: leaflet morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the leaflet are generated and organized." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060777 ! compound leaf morphogenesis + +[Term] +id: GO:0060795 +name: cell fate commitment involved in formation of primary germ layer +namespace: biological_process +def: "The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0001704 ! formation of primary germ layer + +[Term] +id: GO:0060796 +name: obsolete regulation of transcription involved in primary germ layer cell fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0060795 + +[Term] +id: GO:0060797 +name: transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment" EXACT [GOC:mah] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0060795 ! cell fate commitment involved in formation of primary germ layer + +[Term] +id: GO:0060798 +name: transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] +is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment +relationship: part_of GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0060799 +name: transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification" EXACT [GOC:mah] +is_a: GO:0060797 ! transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment +relationship: part_of GO:0001714 ! endodermal cell fate specification + +[Term] +id: GO:0060800 +name: regulation of cell differentiation involved in embryonic placenta development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060706 ! cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060801 +name: negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway +namespace: biological_process +def: "The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway" EXACT [GOC:mah] +is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060802 +name: epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0060803 +name: BMP signaling pathway involved in mesodermal cell fate specification +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "BMP signalling pathway involved in mesodermal cell fate specification" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0007501 ! mesodermal cell fate specification + +[Term] +id: GO:0060804 +name: positive regulation of Wnt signaling pathway by BMP signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in an increase in the rate, frequency or extent of a Wnt signaling pathway." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "positive regulation of WNT receptor signaling pathway by BMP signaling pathway" EXACT [GOC:bf] +synonym: "positive regulation of WNT receptor signalling pathway by BMP signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of Wnt-activated signaling pathway by BMP signaling pathway" EXACT [GOC:signaling] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:0030509 ! BMP signaling pathway + +[Term] +id: GO:0060805 +name: negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060806 ! negative regulation of cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060806 +name: negative regulation of cell differentiation involved in embryonic placenta development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0060800 ! regulation of cell differentiation involved in embryonic placenta development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060706 ! cell differentiation involved in embryonic placenta development + +[Term] +id: GO:0060807 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that ultimately results in a cell being specified to adopt a definitive endodermal cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0001714 +consider: GO:0006357 + +[Term] +id: GO:0060808 +name: positive regulation of mesodermal to mesenchymal transition involved in gastrulation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: positively_regulates GO:0060809 ! mesodermal to mesenchymal transition involved in gastrulation + +[Term] +id: GO:0060809 +name: mesodermal to mesenchymal transition involved in gastrulation +namespace: biological_process +def: "The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001837 ! epithelial to mesenchymal transition +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0060810 +name: intracellular mRNA localization involved in pattern specification process +namespace: biological_process +def: "Any process in which mRNA is transported to, or maintained in, a specific location within an oocyte that results in a pattern being established in the embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "intracellular mRNA localisation involved in pattern specification process" EXACT [GOC:mah] +is_a: GO:0008298 ! intracellular mRNA localization +relationship: part_of GO:0007389 ! pattern specification process + +[Term] +id: GO:0060811 +name: intracellular mRNA localization involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "intracellular mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] +is_a: GO:0060810 ! intracellular mRNA localization involved in pattern specification process +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0060812 +name: orthodenticle mRNA localization +namespace: biological_process +def: "Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "orthodenticle mRNA localisation" EXACT [GOC:mah] +is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification + +[Term] +id: GO:0060813 +name: anterior mRNA localization involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "anterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] +is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification + +[Term] +id: GO:0060814 +name: posterior mRNA localization involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "posterior mRNA localisation involved in anterior/posterior axis specification" EXACT [GOC:mah] +is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification + +[Term] +id: GO:0060815 +name: regulation of translation involved in anterior/posterior axis specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation of mRNAs that contribute to the specification of the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0006417 ! regulation of translation +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0060816 +name: random inactivation of X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:0060817 +name: inactivation of paternal X chromosome +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:0060818 +name: inactivation of paternal X chromosome by genomic imprinting +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genomic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "inactivation of paternal X chromosome by genetic imprinting" RELATED [] +is_a: GO:0060817 ! inactivation of paternal X chromosome +is_a: GO:0060819 ! inactivation of X chromosome by genomic imprinting + +[Term] +id: GO:0060819 +name: inactivation of X chromosome by genomic imprinting +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genomic imprinting." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "inactivation of X chromosome by genetic imprinting" RELATED [] +is_a: GO:0006349 ! regulation of gene expression by genomic imprinting +is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:0060820 +name: inactivation of X chromosome by heterochromatin assembly +namespace: biological_process +def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "inactivation of X chromosome by heterochromatin formation" EXACT [] +is_a: GO:0009048 ! dosage compensation by inactivation of X chromosome +is_a: GO:0140719 ! constitutive heterochromatin assembly + +[Term] +id: GO:0060821 +name: obsolete inactivation of X chromosome by DNA methylation +namespace: biological_process +def: "OBSOLETE. Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by a mechanism of DNA methylation." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0009048 +consider: GO:0035514 + +[Term] +id: GO:0060822 +name: transforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of an axial mesodermal fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in axial mesodermal cell fate specification" EXACT [GOC:mah] +is_a: GO:0060798 ! transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification +relationship: part_of GO:0048327 ! axial mesodermal cell fate specification + +[Term] +id: GO:0060823 +name: canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] +is_a: GO:0060070 ! canonical Wnt signaling pathway +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0060824 +name: retinoic acid receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the formation of the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "retinoic acid receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0060825 +name: fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the anterior/posterior pattern of the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0060826 +name: transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization + +[Term] +id: GO:0060827 +name: regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:signaling] +synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:0060828 +name: regulation of canonical Wnt signaling pathway +namespace: biological_process +alt_id: GO:0035411 +alt_id: GO:0035412 +def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "catenin import into nucleus" NARROW [] +synonym: "regulation of canonical Wnt receptor signaling pathway" EXACT [] +synonym: "regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "regulation of catenin import into nucleus" NARROW [] +synonym: "regulation of catenin protein nuclear translocation" NARROW [GOC:mah] +synonym: "regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: regulates GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:0060829 +name: negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern" EXACT [] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern" EXACT [GOC:signaling] +synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation" EXACT [GOC:mtg_signal] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0060827 ! regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +relationship: negatively_regulates GO:0060823 ! canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:0060830 +name: ciliary receptor clustering involved in smoothened signaling pathway +namespace: biological_process +def: "Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway." [GOC:cilia, GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "ciliary receptor clustering involved in hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "ciliary receptor clustering involved in hh signaling pathway" EXACT [GOC:bf, GOC:ecd] +synonym: "ciliary receptor clustering involved in smoothened signalling pathway" EXACT [GOC:mah] +is_a: GO:0043113 ! receptor clustering +relationship: part_of GO:0007224 ! smoothened signaling pathway + +[Term] +id: GO:0060831 +name: smoothened signaling pathway involved in dorsal/ventral neural tube patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the dorsal/ventral pattern of the neural tube." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:bf, GOC:ecd] +synonym: "smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:mah] +is_a: GO:0007224 ! smoothened signaling pathway +relationship: part_of GO:0021904 ! dorsal/ventral neural tube patterning + +[Term] +id: GO:0060832 +name: oocyte animal/vegetal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0007309 ! oocyte axis specification + +[Term] +id: GO:0060833 +name: Wnt signaling pathway involved in animal/vegetal axis specification +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "Wnt receptor signaling pathway involved in animal/vegetal axis specification" EXACT [] +synonym: "Wnt receptor signalling pathway involved in animal/vegetal axis specification" EXACT [GOC:mah] +synonym: "Wnt- activated signaling pathway involved in animal/vegetal axis specification" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0060832 ! oocyte animal/vegetal axis specification + +[Term] +id: GO:0060834 +name: oral/aboral axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "oral/aboral axis determination" RELATED [GOC:dph] +is_a: GO:0000578 ! embryonic axis specification + +[Term] +id: GO:0060835 +name: transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor receptor beta signalling pathway involved in oral/aboral axis specification" EXACT [GOC:mah] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0060834 ! oral/aboral axis specification + +[Term] +id: GO:0060836 +name: lymphatic endothelial cell differentiation +namespace: biological_process +def: "The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0045446 ! endothelial cell differentiation +relationship: part_of GO:0001945 ! lymph vessel development + +[Term] +id: GO:0060837 +name: blood vessel endothelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0045446 ! endothelial cell differentiation +relationship: part_of GO:0001568 ! blood vessel development + +[Term] +id: GO:0060838 +name: lymphatic endothelial cell fate commitment +namespace: biological_process +def: "The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060839 ! endothelial cell fate commitment +relationship: part_of GO:0060836 ! lymphatic endothelial cell differentiation + +[Term] +id: GO:0060839 +name: endothelial cell fate commitment +namespace: biological_process +def: "The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0072148 ! epithelial cell fate commitment +relationship: part_of GO:0045446 ! endothelial cell differentiation + +[Term] +id: GO:0060840 +name: artery development +namespace: biological_process +def: "The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001568 ! blood vessel development + +[Term] +id: GO:0060841 +name: venous blood vessel development +namespace: biological_process +def: "The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001568 ! blood vessel development + +[Term] +id: GO:0060842 +name: arterial endothelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0060843 +name: venous endothelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0060844 +name: arterial endothelial cell fate commitment +namespace: biological_process +def: "The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060846 ! blood vessel endothelial cell fate commitment +relationship: part_of GO:0060842 ! arterial endothelial cell differentiation + +[Term] +id: GO:0060845 +name: venous endothelial cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060846 ! blood vessel endothelial cell fate commitment +relationship: part_of GO:0060843 ! venous endothelial cell differentiation + +[Term] +id: GO:0060846 +name: blood vessel endothelial cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060839 ! endothelial cell fate commitment +relationship: part_of GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0060847 +name: endothelial cell fate specification +namespace: biological_process +def: "The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0060839 ! endothelial cell fate commitment + +[Term] +id: GO:0060848 +name: endothelial cell fate determination +namespace: biological_process +def: "A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0060839 ! endothelial cell fate commitment + +[Term] +id: GO:0060849 +name: obsolete regulation of transcription involved in lymphatic endothelial cell fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0060838 + +[Term] +id: GO:0060850 +name: obsolete regulation of transcription involved in cell fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0045165 + +[Term] +id: GO:0060851 +name: vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment +namespace: biological_process +def: "The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a venous endothelial cell to a lymphatic endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "vascular endothelial growth factor receptor signalling pathway involved in lymphatic endothelial cell fate commitment" EXACT [GOC:mah] +is_a: GO:0048010 ! vascular endothelial growth factor receptor signaling pathway +relationship: part_of GO:0060838 ! lymphatic endothelial cell fate commitment + +[Term] +id: GO:0060852 +name: obsolete regulation of transcription involved in venous endothelial cell fate commitment +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a cell to a specific fate and contributes to a cell adopting a venous endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0060845 + +[Term] +id: GO:0060853 +name: Notch signaling pathway involved in arterial endothelial cell fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "Notch signalling pathway involved in arterial endothelial cell fate commitment" EXACT [GOC:mah] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0060844 ! arterial endothelial cell fate commitment + +[Term] +id: GO:0060854 +name: branching involved in lymph vessel morphogenesis +namespace: biological_process +def: "The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "patterning of lymph vessels" BROAD [GOC:dph] +is_a: GO:0048754 ! branching morphogenesis of an epithelial tube +relationship: part_of GO:0001946 ! lymphangiogenesis + +[Term] +id: GO:0060855 +name: venous endothelial cell migration involved in lymph vessel development +namespace: biological_process +def: "The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0043534 ! blood vessel endothelial cell migration +relationship: part_of GO:0001945 ! lymph vessel development + +[Term] +id: GO:0060856 +name: establishment of blood-brain barrier +namespace: biological_process +def: "Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:aruk, GOC:dph, GOC:sart, PMID:20080302, PMID:30280653] +synonym: "establishment of BBB" EXACT [] +synonym: "establishment of blood/brain barrier" EXACT [] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:0060857 +name: establishment of glial blood-brain barrier +namespace: biological_process +def: "Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dph, GOC:sart, PMID:20080302] +synonym: "establishment of glial BBB" EXACT [] +synonym: "establishment of glial blood/brain barrier" EXACT [] +is_a: GO:0021782 ! glial cell development +is_a: GO:0060856 ! establishment of blood-brain barrier + +[Term] +id: GO:0060858 +name: vesicle-mediated transport involved in floral organ abscission +namespace: biological_process +def: "The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "membrane trafficking involved in floral organ shedding" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060859 +name: obsolete regulation of vesicle-mediated transport involved in floral organ abscission +namespace: biological_process +def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of the directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0060860 +name: regulation of floral organ abscission +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060861 +name: positive regulation of floral organ abscission +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of floral organ shedding, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0060860 ! regulation of floral organ abscission +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060862 +name: negative regulation of floral organ abscission +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of floral organ abscission, the controlled shedding of floral organs." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0060860 ! regulation of floral organ abscission +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060863 +name: regulation of floral organ abscission by signal transduction +namespace: biological_process +def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately modulating the rate, or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0007165 ! signal transduction +is_a: GO:0060860 ! regulation of floral organ abscission + +[Term] +id: GO:0060864 +name: obsolete positive regulation of floral organ abscission by small GTPase mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that increases the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0060865 +name: negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand and contributing to the decrease in the rate or frequency of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "negative regulation of floral organ abscission by transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:0060862 ! negative regulation of floral organ abscission +is_a: GO:0060863 ! regulation of floral organ abscission by signal transduction + +[Term] +id: GO:0060866 +name: leaf abscission +namespace: biological_process +def: "The controlled shedding of a leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009838 ! abscission + +[Term] +id: GO:0060867 +name: fruit abscission +namespace: biological_process +def: "The controlled shedding of a fruit." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009838 ! abscission + +[Term] +id: GO:0060868 +name: obsolete regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it does not represent a specific pathway. +is_obsolete: true + +[Term] +id: GO:0060869 +name: transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:signaling, GOC:tb] +synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway involved in floral organ abscission" EXACT [GOC:mah] +is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060870 +name: cell wall disassembly involved in floral organ abscission +namespace: biological_process +def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009830 ! cell wall modification involved in abscission +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0010227 ! floral organ abscission + +[Term] +id: GO:0060872 +name: semicircular canal development +namespace: biological_process +def: "The progression of the semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0060873 +name: anterior semicircular canal development +namespace: biological_process +def: "The progession of the anterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060872 ! semicircular canal development + +[Term] +id: GO:0060874 +name: posterior semicircular canal development +namespace: biological_process +def: "The progession of the posterior semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060872 ! semicircular canal development + +[Term] +id: GO:0060875 +name: lateral semicircular canal development +namespace: biological_process +def: "The progession of the lateral semicircular canal from its initial formation to the mature structure." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060872 ! semicircular canal development + +[Term] +id: GO:0060876 +name: semicircular canal formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0035148 ! tube formation +relationship: part_of GO:0048752 ! semicircular canal morphogenesis + +[Term] +id: GO:0060877 +name: regionalization involved in semicircular canal formation +namespace: biological_process +def: "The pattern specification process that results in the subdivision of the otic epithelium in space to define an area or volume in which cells will differentiate to give rise to the semicircular canals." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0060876 ! semicircular canal formation + +[Term] +id: GO:0060878 +name: pouch outgrowth involved in semicircular canal formation +namespace: biological_process +def: "The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0060571 ! morphogenesis of an epithelial fold +relationship: part_of GO:0060876 ! semicircular canal formation + +[Term] +id: GO:0060879 +name: semicircular canal fusion +namespace: biological_process +def: "Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060606 ! tube closure +relationship: part_of GO:0060876 ! semicircular canal formation + +[Term] +id: GO:0060880 +name: cell morphogenesis involved in semicircular canal fusion +namespace: biological_process +def: "The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0060879 ! semicircular canal fusion + +[Term] +id: GO:0060882 +name: basement membrane disassembly involved in semicircular canal fusion +namespace: biological_process +def: "A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "basal lamina disassembly involved in semicircular canal fusion" RELATED [] +is_a: GO:0034769 ! basement membrane disassembly +relationship: part_of GO:0060879 ! semicircular canal fusion + +[Term] +id: GO:0060883 +name: regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication +namespace: biological_process +def: "Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication" RELATED [] +is_a: GO:0007154 ! cell communication +is_a: GO:0010715 ! regulation of extracellular matrix disassembly +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0110011 ! regulation of basement membrane organization +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0060882 ! basement membrane disassembly involved in semicircular canal fusion + +[Term] +id: GO:0060884 +name: clearance of cells from fusion plate +namespace: biological_process +def: "The morphogenetic process in which cells are removed from the inner loop of a semicircular canal." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0002009 ! morphogenesis of an epithelium +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0048752 ! semicircular canal morphogenesis + +[Term] +id: GO:0060885 +name: clearance of cells from fusion plate by apoptotic process +namespace: biological_process +def: "Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals." [GOC:dph, GOC:mtg_apoptosis, GOC:sdb_2009, GOC:tb] +synonym: "clearance of cells from fusion plate by apoptosis" NARROW [] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +is_a: GO:0060884 ! clearance of cells from fusion plate + +[Term] +id: GO:0060886 +name: clearance of cells from fusion plate by epithelial to mesenchymal transition +namespace: biological_process +def: "The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0001837 ! epithelial to mesenchymal transition +is_a: GO:0060884 ! clearance of cells from fusion plate + +[Term] +id: GO:0060887 +name: limb epidermis development +namespace: biological_process +def: "The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0098773 ! skin epidermis development +relationship: part_of GO:0060173 ! limb development + +[Term] +id: GO:0060888 +name: limb epidermis stratification +namespace: biological_process +def: "The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0003002 ! regionalization +is_a: GO:0060887 ! limb epidermis development + +[Term] +id: GO:0060889 +name: limb basal epidermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009913 ! epidermal cell differentiation +is_a: GO:0048863 ! stem cell differentiation +relationship: part_of GO:0060887 ! limb epidermis development + +[Term] +id: GO:0060890 +name: limb spinous cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0030216 ! keratinocyte differentiation +relationship: part_of GO:0060887 ! limb epidermis development + +[Term] +id: GO:0060891 +name: limb granular cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0030216 ! keratinocyte differentiation +relationship: part_of GO:0060887 ! limb epidermis development + +[Term] +id: GO:0060892 +name: limb basal epidermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009957 ! epidermal cell fate specification +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0060888 ! limb epidermis stratification +relationship: part_of GO:0060889 ! limb basal epidermal cell differentiation + +[Term] +id: GO:0060893 +name: limb granular cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009957 ! epidermal cell fate specification +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0060888 ! limb epidermis stratification +relationship: part_of GO:0060891 ! limb granular cell differentiation + +[Term] +id: GO:0060894 +name: limb spinous cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009957 ! epidermal cell fate specification +is_a: GO:0060573 ! cell fate specification involved in pattern specification +relationship: part_of GO:0060888 ! limb epidermis stratification +relationship: part_of GO:0060890 ! limb spinous cell differentiation + +[Term] +id: GO:0060895 +name: retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to the dorsal ventral patterning of the spinal cord." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "retinoic acid receptor signalling pathway involved in spinal cord dorsal/ventral patterning" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning + +[Term] +id: GO:0060896 +name: neural plate pattern specification +namespace: biological_process +def: "The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0060897 +name: neural plate regionalization +namespace: biological_process +def: "The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0003002 ! regionalization +is_a: GO:0060896 ! neural plate pattern specification + +[Term] +id: GO:0060898 +name: eye field cell fate commitment involved in camera-type eye formation +namespace: biological_process +def: "The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0060581 ! cell fate commitment involved in pattern specification +relationship: part_of GO:0046619 ! lens placode formation involved in camera-type eye formation +relationship: part_of GO:0060897 ! neural plate regionalization + +[Term] +id: GO:0060899 +name: obsolete regulation of transcription involved in eye field cell fate commitment of camera-type eye +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neurectodermal cell to a specialized neurectodermal cell that will give rise to the optic vesicle." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0060898 + +[Term] +id: GO:0060900 +name: embryonic camera-type eye formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis + +[Term] +id: GO:0060901 +name: regulation of hair cycle by canonical Wnt signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "regulation of hair cycle by canonical Wnt receptor signaling pathway" EXACT [] +synonym: "regulation of hair cycle by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of hair cycle by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "regulation of hair cycle by Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] +is_a: GO:0042634 ! regulation of hair cycle +is_a: GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:0060902 +name: regulation of hair cycle by BMP signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that modulates the rate, frequency or extent of the hair cycle." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "regulation of hair cycle by BMP signalling pathway" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +is_a: GO:0042634 ! regulation of hair cycle + +[Term] +id: GO:0060903 +name: positive regulation of meiosis I +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:tb] +is_a: GO:0045836 ! positive regulation of meiotic nuclear division +is_a: GO:0060631 ! regulation of meiosis I +relationship: positively_regulates GO:0007127 ! meiosis I + +[Term] +id: GO:0060904 +name: regulation of protein folding in endoplasmic reticulum +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation)." [GOC:dph, GOC:tb] +is_a: GO:1903332 ! regulation of protein folding +relationship: regulates GO:0034975 ! protein folding in endoplasmic reticulum + +[Term] +id: GO:0060905 +name: regulation of induction of conjugation upon nitrogen starvation +namespace: biological_process +def: "Any process that modulates the frequency of induction of conjugation upon nitrogen starvation, the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:dph, GOC:tb] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0031137 ! regulation of conjugation with cellular fusion +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0031142 ! induction of conjugation upon nitrogen starvation + +[Term] +id: GO:0060906 +name: negative regulation of heterochromatin assembly by small RNA +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of heterochromatin assembly by small RNA." [GOC:dph, GOC:tb] +synonym: "negative regulation of chromatin silencing by small RNA" RELATED [] +synonym: "negative regulation of RNAi-mediated heterochromatin assembly" EXACT [] +is_a: GO:0010964 ! regulation of heterochromatin assembly by small RNA +is_a: GO:0031452 ! negative regulation of heterochromatin assembly +relationship: negatively_regulates GO:0031048 ! heterochromatin assembly by small RNA + +[Term] +id: GO:0060907 +name: positive regulation of macrophage cytokine production +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:dph, GOC:tb] +is_a: GO:0010935 ! regulation of macrophage cytokine production +is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response +relationship: positively_regulates GO:0010934 ! macrophage cytokine production + +[Term] +id: GO:0060908 +name: plasmid copy number maintenance +namespace: biological_process +def: "The maintenance of the number of copies of extrachromosomal plasmid DNA." [GOC:dph, GOC:tb] +is_a: GO:0006276 ! plasmid maintenance + +[Term] +id: GO:0060909 +name: regulation of DNA replication initiation involved in plasmid copy number maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] +is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation +relationship: part_of GO:0060908 ! plasmid copy number maintenance + +[Term] +id: GO:0060910 +name: negative regulation of DNA replication initiation involved in plasmid copy number maintenance +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance." [GOC:dph, GOC:tb] +is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation +is_a: GO:0060909 ! regulation of DNA replication initiation involved in plasmid copy number maintenance + +[Term] +id: GO:0060911 +name: cardiac cell fate commitment +namespace: biological_process +def: "The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system." [GOC:mtg_heart] +synonym: "cardiocyte cell fate commitment" EXACT [GOC:dph] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:0060912 +name: cardiac cell fate specification +namespace: biological_process +def: "The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:mtg_heart] +synonym: "cardiocyte cell fate specification" EXACT [GOC:dph] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0060911 ! cardiac cell fate commitment + +[Term] +id: GO:0060913 +name: cardiac cell fate determination +namespace: biological_process +def: "The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:mtg_heart] +synonym: "cardiocyte cell fate determination" RELATED [GOC:dph] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0060911 ! cardiac cell fate commitment + +[Term] +id: GO:0060914 +name: heart formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable." [GOC:mtg_heart] +synonym: "cardiogenesis" RELATED [GOC:mtg_heart] +is_a: GO:0048645 ! animal organ formation +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0060915 +name: mesenchymal cell differentiation involved in lung development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph] +is_a: GO:0048762 ! mesenchymal cell differentiation +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060916 +name: mesenchymal cell proliferation involved in lung development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph] +is_a: GO:0010463 ! mesenchymal cell proliferation +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0060917 +name: regulation of (1->6)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:dph, GOC:tb] +synonym: "regulation of 1,6-beta-glucan biosynthetic process" EXACT [] +is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process +relationship: regulates GO:0006078 ! (1->6)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0060918 +name: auxin transport +namespace: biological_process +def: "The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0009914 ! hormone transport + +[Term] +id: GO:0060919 +name: auxin influx +namespace: biological_process +def: "The process involved in the transport of auxin into the cell." [GOC:dph, GOC:tb] +is_a: GO:0060918 ! auxin transport + +[Term] +id: GO:0060920 +name: cardiac pacemaker cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +synonym: "pacemaker cell differentiation" BROAD [] +is_a: GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0060921 +name: sinoatrial node cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] +synonym: "SA node cell differentiation" EXACT [GOC:mtg_heart] +synonym: "SAN cell differentiation" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "sinus node cell differentiation" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0060920 ! cardiac pacemaker cell differentiation +relationship: part_of GO:0003163 ! sinoatrial node development + +[Term] +id: GO:0060922 +name: atrioventricular node cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node." [GOC:mtg_heart] +synonym: "AV node cell differentiation" RELATED [GOC:mtg_heart] +is_a: GO:0003292 ! cardiac septum cell differentiation +is_a: GO:0060920 ! cardiac pacemaker cell differentiation +relationship: part_of GO:0003162 ! atrioventricular node development + +[Term] +id: GO:0060923 +name: cardiac muscle cell fate commitment +namespace: biological_process +def: "The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] +synonym: "cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] +synonym: "heart muscle cell fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0042693 ! muscle cell fate commitment +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:0060924 +name: atrial cardiac muscle cell fate commitment +namespace: biological_process +def: "The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] +synonym: "atrial cardiomyocyte cell fate commitment" RELATED [GOC:mtg_heart] +synonym: "atrial heart muscle cell fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0060923 ! cardiac muscle cell fate commitment +relationship: part_of GO:0055011 ! atrial cardiac muscle cell differentiation + +[Term] +id: GO:0060925 +name: ventricular cardiac muscle cell fate commitment +namespace: biological_process +def: "The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [GOC:mtg_heart] +synonym: "ventricular cardiomyocyte cell fate commitment" EXACT [GOC:mtg_heart] +synonym: "ventricular heart muscle cell fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0060923 ! cardiac muscle cell fate commitment +relationship: part_of GO:0055012 ! ventricular cardiac muscle cell differentiation + +[Term] +id: GO:0060926 +name: cardiac pacemaker cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +synonym: "pacemaker cell development" BROAD [] +is_a: GO:0055013 ! cardiac muscle cell development +relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation + +[Term] +id: GO:0060927 +name: cardiac pacemaker cell fate commitment +namespace: biological_process +def: "The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] +synonym: "pacemaker cell fate commitment" BROAD [] +is_a: GO:0060923 ! cardiac muscle cell fate commitment +relationship: part_of GO:0060920 ! cardiac pacemaker cell differentiation + +[Term] +id: GO:0060928 +name: atrioventricular node cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state." [GOC:mtg_heart] +synonym: "AV node cell development" EXACT [GOC:mtg_heart] +is_a: GO:0060926 ! cardiac pacemaker cell development +relationship: part_of GO:0060922 ! atrioventricular node cell differentiation + +[Term] +id: GO:0060929 +name: atrioventricular node cell fate commitment +namespace: biological_process +def: "The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells." [GOC:mtg_heart] +synonym: "AV node cell fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0060927 ! cardiac pacemaker cell fate commitment +relationship: part_of GO:0060922 ! atrioventricular node cell differentiation + +[Term] +id: GO:0060930 +name: sinoatrial node cell fate commitment +namespace: biological_process +def: "The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] +synonym: "SA node cell commitment" EXACT [GOC:mtg_heart] +synonym: "SAN cell commitment" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "sinus node cell commitment" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0060927 ! cardiac pacemaker cell fate commitment +relationship: part_of GO:0060921 ! sinoatrial node cell differentiation + +[Term] +id: GO:0060931 +name: sinoatrial node cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node." [GOC:mtg_heart] +synonym: "SA node cell development" EXACT [GOC:mtg_heart] +synonym: "SAN cell development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "sinus node cell development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0060926 ! cardiac pacemaker cell development +relationship: part_of GO:0060921 ! sinoatrial node cell differentiation + +[Term] +id: GO:0060932 +name: His-Purkinje system cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] +is_a: GO:0055007 ! cardiac muscle cell differentiation +relationship: part_of GO:0003164 ! His-Purkinje system development + +[Term] +id: GO:0060933 +name: His-Purkinje system cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation + +[Term] +id: GO:0060934 +name: His-Purkinje system cell fate commitment +namespace: biological_process +def: "The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0060932 ! His-Purkinje system cell differentiation + +[Term] +id: GO:0060935 +name: cardiac fibroblast cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:0060936 +name: cardiac fibroblast cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation + +[Term] +id: GO:0060937 +name: cardiac fibroblast cell fate commitment +namespace: biological_process +def: "The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0060935 ! cardiac fibroblast cell differentiation + +[Term] +id: GO:0060938 +name: epicardium-derived cardiac fibroblast cell differentiation +namespace: biological_process +def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060935 ! cardiac fibroblast cell differentiation + +[Term] +id: GO:0060939 +name: epicardium-derived cardiac fibroblast cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060936 ! cardiac fibroblast cell development +relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation + +[Term] +id: GO:0060940 +name: epithelial to mesenchymal transition involved in cardiac fibroblast development +namespace: biological_process +def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast." [GOC:mtg_heart] +is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition +relationship: part_of GO:0060939 ! epicardium-derived cardiac fibroblast cell development + +[Term] +id: GO:0060941 +name: epicardium-derived cardiac fibroblast cell fate commitment +namespace: biological_process +def: "The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060937 ! cardiac fibroblast cell fate commitment +relationship: part_of GO:0060938 ! epicardium-derived cardiac fibroblast cell differentiation + +[Term] +id: GO:0060942 +name: neural crest-derived cardiac fibroblast cell differentiation +namespace: biological_process +def: "The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060935 ! cardiac fibroblast cell differentiation + +[Term] +id: GO:0060943 +name: neural crest-derived cardiac fibroblast cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060936 ! cardiac fibroblast cell development +relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation + +[Term] +id: GO:0060944 +name: neural crest-derived cardiac fibroblast cell fate commitment +namespace: biological_process +def: "The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:mtg_heart] +is_a: GO:0060937 ! cardiac fibroblast cell fate commitment +relationship: part_of GO:0060942 ! neural crest-derived cardiac fibroblast cell differentiation + +[Term] +id: GO:0060945 +name: cardiac neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart." [GOC:mtg_heart] +synonym: "heart neuron differentiation" EXACT [GOC:mtg_heart] +is_a: GO:0030182 ! neuron differentiation +is_a: GO:0035051 ! cardiocyte differentiation +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:0060946 +name: cardiac blood vessel endothelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels." [GOC:mtg_heart] +is_a: GO:0003348 ! cardiac endothelial cell differentiation +is_a: GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0060947 +name: cardiac vascular smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] +synonym: "heart vascular smooth muscle cell differentiation" EXACT [GOC:mtg_heart] +is_a: GO:0035051 ! cardiocyte differentiation +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation +relationship: part_of GO:0060976 ! coronary vasculature development + +[Term] +id: GO:0060948 +name: cardiac vascular smooth muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state." [GOC:mtg_heart] +synonym: "heart vascular smooth muscle cell development" EXACT [GOC:mtg_heart] +is_a: GO:0055006 ! cardiac cell development +is_a: GO:0097084 ! vascular associated smooth muscle cell development +relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:0060949 +name: cardiac vascular smooth muscle cell fate commitment +namespace: biological_process +def: "The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] +synonym: "heart vascular smooth muscle cell fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0060911 ! cardiac cell fate commitment +is_a: GO:0097081 ! vascular associated smooth muscle cell fate commitment +relationship: part_of GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:0060950 +name: cardiac glial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] +is_a: GO:0010001 ! glial cell differentiation +is_a: GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:0060951 +name: neural crest-derived cardiac glial cell differentiation +namespace: biological_process +def: "The process in which a neural crest cell acquires the specialized features of a glial cell of the heart." [GOC:mtg_heart] +is_a: GO:0060950 ! cardiac glial cell differentiation + +[Term] +id: GO:0060952 +name: cardiac glial cell development +namespace: biological_process +def: "The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell." [GOC:mtg_heart] +is_a: GO:0021782 ! glial cell development +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0060950 ! cardiac glial cell differentiation + +[Term] +id: GO:0060953 +name: cardiac glial cell fate commitment +namespace: biological_process +def: "The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] +is_a: GO:0021781 ! glial cell fate commitment +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0060950 ! cardiac glial cell differentiation + +[Term] +id: GO:0060954 +name: neural crest-derived cardiac glial cell development +namespace: biological_process +def: "The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:mtg_heart] +is_a: GO:0060952 ! cardiac glial cell development +relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation + +[Term] +id: GO:0060955 +name: neural crest-derived cardiac glial cell fate commitment +namespace: biological_process +def: "The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells." [GOC:mtg_heart] +is_a: GO:0060953 ! cardiac glial cell fate commitment +relationship: part_of GO:0060951 ! neural crest-derived cardiac glial cell differentiation + +[Term] +id: GO:0060956 +name: endocardial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] +is_a: GO:0003348 ! cardiac endothelial cell differentiation +relationship: part_of GO:0003157 ! endocardium development + +[Term] +id: GO:0060957 +name: endocardial cell fate commitment +namespace: biological_process +def: "The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] +is_a: GO:0060839 ! endothelial cell fate commitment +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0060956 ! endocardial cell differentiation + +[Term] +id: GO:0060958 +name: endocardial cell development +namespace: biological_process +def: "The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart." [GOC:mtg_heart] +is_a: GO:0001885 ! endothelial cell development +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0060956 ! endocardial cell differentiation + +[Term] +id: GO:0060959 +name: cardiac neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state." [GOC:mtg_heart] +synonym: "heart neuron development" EXACT [GOC:mtg_heart] +is_a: GO:0048666 ! neuron development +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0060945 ! cardiac neuron differentiation + +[Term] +id: GO:0060960 +name: cardiac neuron fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart." [GOC:mtg_heart] +synonym: "heart neuron fate commitment" EXACT [GOC:mtg_heart] +is_a: GO:0048663 ! neuron fate commitment +is_a: GO:0060911 ! cardiac cell fate commitment +relationship: part_of GO:0060945 ! cardiac neuron differentiation + +[Term] +id: GO:0060961 +name: phospholipase D inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of phospholipase D." [GOC:dph, GOC:tb] +is_a: GO:0004859 ! phospholipase inhibitor activity + +[Term] +id: GO:0060962 +name: regulation of ribosomal protein gene transcription by RNA polymerase II +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] +synonym: "regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II + +[Term] +id: GO:0060963 +name: positive regulation of ribosomal protein gene transcription by RNA polymerase II +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] +synonym: "positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II + +[Term] +id: GO:0060964 +name: regulation of gene silencing by miRNA +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604] +synonym: "regulation of gene silencing by microRNA" EXACT [GOC:pr] +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +is_a: GO:0060966 ! regulation of gene silencing by RNA +relationship: regulates GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0060965 +name: negative regulation of gene silencing by miRNA +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of gene silencing by miRNA." [GOC:aruk, GOC:bc, GOC:dph, GOC:rl, GOC:tb, PMID:23985560, PMID:28379604] +synonym: "negative regulation of gene silencing by microRNA" EXACT [GOC:bf, GOC:pr] +is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing +is_a: GO:0060964 ! regulation of gene silencing by miRNA +is_a: GO:0060967 ! negative regulation of gene silencing by RNA +relationship: negatively_regulates GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:0060966 +name: regulation of gene silencing by RNA +namespace: biological_process +def: "Any process that regulates the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0060967 +name: negative regulation of gene silencing by RNA +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of gene silencing by RNA. Gene silencing by RNA is the process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:tb] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0060966 ! regulation of gene silencing by RNA +relationship: negatively_regulates GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0060968 +name: obsolete regulation of gene silencing +namespace: biological_process +def: "OBSOLETE. Any process that modulates the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it was too broadly defined and could not be distinguished from 'GO:0040029 regulation of gene expression, epigenetic'. +is_obsolete: true +consider: GO:0040029 + +[Term] +id: GO:0060969 +name: obsolete negative regulation of gene silencing +namespace: biological_process +def: "OBSOLETE. Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:tb] +comment: This term was obsoleted because its definition was too broad. +is_obsolete: true +consider: GO:0010629 +consider: GO:0031047 +consider: GO:0031507 + +[Term] +id: GO:0060970 +name: embryonic heart tube dorsal/ventral pattern formation +namespace: biological_process +def: "The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis." [GOC:mtg_heart] +is_a: GO:0009953 ! dorsal/ventral pattern formation +relationship: part_of GO:0035050 ! embryonic heart tube development + +[Term] +id: GO:0060971 +name: embryonic heart tube left/right pattern formation +namespace: biological_process +def: "The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place." [GOC:mtg_heart] +is_a: GO:0060972 ! left/right pattern formation +relationship: part_of GO:0035050 ! embryonic heart tube development + +[Term] +id: GO:0060972 +name: left/right pattern formation +namespace: biological_process +def: "The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:mtg_heart] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0060973 +name: cell migration involved in heart development +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ." [GOC:mtg_heart] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060974 +name: cell migration involved in heart formation +namespace: biological_process +def: "The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells." [GOC:mtg_heart] +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0060914 ! heart formation + +[Term] +id: GO:0060975 +name: cardioblast migration to the midline involved in heart field formation +namespace: biological_process +def: "The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] +synonym: "cardiac progenitor cell midline migration" EXACT [GOC:mtg_heart] +synonym: "cardioblast midline convergence" EXACT [GOC:mtg_heart] +is_a: GO:0003260 ! cardioblast migration +is_a: GO:0003318 ! cell migration to the midline involved in heart development +relationship: part_of GO:0060029 ! convergent extension involved in organogenesis + +[Term] +id: GO:0060976 +name: coronary vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure." [GOC:mtg_heart] +synonym: "cardiac blood vessel development" EXACT [GOC:mtg_heart] +synonym: "cardiac vasculature development" EXACT [GOC:mtg_heart] +synonym: "coronary blood vessel development" EXACT [GOC:mtg_heart] +synonym: "heart blood vessel development" EXACT [GOC:mtg_heart] +synonym: "heart vasculature development" EXACT [GOC:mtg_heart] +is_a: GO:0001568 ! blood vessel development +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0060977 +name: coronary vasculature morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood." [GOC:mtg_heart] +synonym: "cardiac blood vessel morphogenesis" EXACT [GOC:mtg_heart] +synonym: "cardiac vasculature morphogenesis" EXACT [GOC:mtg_heart] +synonym: "coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] +synonym: "heart blood vessel morphogenesis" EXACT [GOC:mtg_heart] +synonym: "heart vasculature morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0048514 ! blood vessel morphogenesis +relationship: part_of GO:0060976 ! coronary vasculature development + +[Term] +id: GO:0060978 +name: angiogenesis involved in coronary vascular morphogenesis +namespace: biological_process +def: "Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels." [GOC:mtg_heart] +synonym: "angiogenesis involved in cardiac vascular morphogenesis" EXACT [GOC:mtg_heart] +synonym: "angiogenesis involved in heart vascular morphogenesis" EXACT [GOC:mtg_heart] +synonym: "coronary blood vessel angiogenesis" EXACT [GOC:mtg_heart] +synonym: "coronary vasculature angiogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0001525 ! angiogenesis +relationship: part_of GO:0060977 ! coronary vasculature morphogenesis + +[Term] +id: GO:0060979 +name: vasculogenesis involved in coronary vascular morphogenesis +namespace: biological_process +def: "The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes." [GOC:mtg_heart] +synonym: "coronary vasculogenesis" EXACT [GOC:mtg_heart] +synonym: "vasculogenesis involved in coronary blood vessel morphogenesis" EXACT [GOC:mtg_heart] +is_a: GO:0001570 ! vasculogenesis +relationship: part_of GO:0060977 ! coronary vasculature morphogenesis + +[Term] +id: GO:0060980 +name: cell migration involved in coronary vasculogenesis +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart." [GOC:mtg_heart] +is_a: GO:0035441 ! cell migration involved in vasculogenesis +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0060979 ! vasculogenesis involved in coronary vascular morphogenesis + +[Term] +id: GO:0060981 +name: cell migration involved in coronary angiogenesis +namespace: biological_process +def: "The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels." [GOC:mtg_heart] +is_a: GO:0060973 ! cell migration involved in heart development +relationship: part_of GO:0060978 ! angiogenesis involved in coronary vascular morphogenesis + +[Term] +id: GO:0060982 +name: coronary artery morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle." [GOC:mtg_heart] +is_a: GO:0048844 ! artery morphogenesis +is_a: GO:0060977 ! coronary vasculature morphogenesis + +[Term] +id: GO:0060983 +name: epicardium-derived cardiac vascular smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers." [GOC:mtg_heart] +is_a: GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:0060984 +name: epicardium-derived cardiac vascular smooth muscle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state." [GOC:mtg_heart] +is_a: GO:0060948 ! cardiac vascular smooth muscle cell development +relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:0060985 +name: epicardium-derived cardiac vascular smooth muscle cell fate commitment +namespace: biological_process +def: "The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell." [GOC:mtg_heart] +is_a: GO:0060949 ! cardiac vascular smooth muscle cell fate commitment +relationship: part_of GO:0060983 ! epicardium-derived cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:0060986 +name: endocrine hormone secretion +namespace: biological_process +def: "The regulated release of a hormone into the circulatory system." [GOC:dph] +is_a: GO:0046879 ! hormone secretion +relationship: part_of GO:0050886 ! endocrine process + +[Term] +id: GO:0060987 +name: lipid tube +namespace: cellular_component +def: "A macromolecular complex that contains a tube of lipid surrounded by a protein coat." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032994 ! protein-lipid complex + +[Term] +id: GO:0060988 +name: lipid tube assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "lipid tubulation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0065005 ! protein-lipid complex assembly + +[Term] +id: GO:0060989 +name: lipid tube assembly involved in organelle fusion +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "lipid tubulation involved in organelle fusion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060988 ! lipid tube assembly +relationship: part_of GO:0048284 ! organelle fusion + +[Term] +id: GO:0060990 +name: lipid tube assembly involved in organelle fission +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles undergo fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "lipid tubulation involved in organelle fission" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060988 ! lipid tube assembly +relationship: part_of GO:0048285 ! organelle fission + +[Term] +id: GO:0060991 +name: obsolete lipid tube assembly involved in cytokinesis +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in cytokinesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was made obsolete because there is no evidence the process exists. +synonym: "lipid tube assembly involved in cytokinesis" EXACT [] +synonym: "lipid tubulation involved in cytokinesis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0060992 +name: response to fungicide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi." [GOC:dph] +is_a: GO:0009636 ! response to toxic substance +is_a: GO:0046677 ! response to antibiotic + +[Term] +id: GO:0060993 +name: kidney morphogenesis +namespace: biological_process +def: "Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0060994 +name: regulation of transcription from RNA polymerase II promoter involved in kidney development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the kidney progresses from its initial formation to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0060995 +name: cell-cell signaling involved in kidney development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." [GOC:dph, GOC:mtg_kidney_jan10] +synonym: "cell-cell signalling involved in kidney development" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0060996 +name: dendritic spine development +namespace: biological_process +def: "The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0016358 ! dendrite development + +[Term] +id: GO:0060997 +name: dendritic spine morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] +is_a: GO:0031175 ! neuron projection development +is_a: GO:0048812 ! neuron projection morphogenesis +is_a: GO:0097061 ! dendritic spine organization +relationship: part_of GO:0048813 ! dendrite morphogenesis +relationship: part_of GO:0060996 ! dendritic spine development + +[Term] +id: GO:0060998 +name: regulation of dendritic spine development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060996 ! dendritic spine development + +[Term] +id: GO:0060999 +name: positive regulation of dendritic spine development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0060998 ! regulation of dendritic spine development +relationship: positively_regulates GO:0060996 ! dendritic spine development + +[Term] +id: GO:0061000 +name: negative regulation of dendritic spine development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0060998 ! regulation of dendritic spine development +relationship: negatively_regulates GO:0060996 ! dendritic spine development + +[Term] +id: GO:0061001 +name: regulation of dendritic spine morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0099175 ! regulation of postsynapse organization +relationship: regulates GO:0060997 ! dendritic spine morphogenesis + +[Term] +id: GO:0061002 +name: negative regulation of dendritic spine morphogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] +is_a: GO:0010977 ! negative regulation of neuron projection development +is_a: GO:0061000 ! negative regulation of dendritic spine development +is_a: GO:0061001 ! regulation of dendritic spine morphogenesis +relationship: negatively_regulates GO:0060997 ! dendritic spine morphogenesis + +[Term] +id: GO:0061003 +name: positive regulation of dendritic spine morphogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission." [GOC:dph] +is_a: GO:0010976 ! positive regulation of neuron projection development +is_a: GO:0050775 ! positive regulation of dendrite morphogenesis +is_a: GO:0060999 ! positive regulation of dendritic spine development +is_a: GO:0061001 ! regulation of dendritic spine morphogenesis +relationship: positively_regulates GO:0060997 ! dendritic spine morphogenesis + +[Term] +id: GO:0061004 +name: pattern specification involved in kidney development +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate." [GOC:dph, GOC:mtg_kidney_jan10] +synonym: "kidney pattern formation" RELATED [GOC:mtg_kidney_jan10] +synonym: "kidney pattern specification" EXACT [GOC:mtg_kidney_jan10] +synonym: "pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0001822 ! kidney development +relationship: part_of GO:0072048 ! renal system pattern specification + +[Term] +id: GO:0061005 +name: cell differentiation involved in kidney development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0061006 +name: regulation of cell proliferation involved in kidney morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: part_of GO:0060993 ! kidney morphogenesis + +[Term] +id: GO:0061007 +name: hepaticobiliary system process +namespace: biological_process +def: "An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] +subset: goslim_generic +synonym: "hepatobiliary system process" EXACT [GOC:dph] +is_a: GO:0003008 ! system process + +[Term] +id: GO:0061008 +name: hepaticobiliary system development +namespace: biological_process +def: "The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins." [GOC:dph] +synonym: "hepatobiliary system development" EXACT [GOC:dph] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0061009 +name: common bile duct development +namespace: biological_process +def: "The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine." [PMID:20614624] +synonym: "bile duct development" EXACT [GOC:dph] +synonym: "CBD development" EXACT [PMID:20614624] +synonym: "EHBD development" BROAD [PMID:20614624] +synonym: "extrahepatic bile duct development" BROAD [PMID:20614624] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0061008 ! hepaticobiliary system development + +[Term] +id: GO:0061010 +name: gall bladder development +namespace: biological_process +def: "The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." [GOC:dph] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0061008 ! hepaticobiliary system development + +[Term] +id: GO:0061011 +name: hepatic duct development +namespace: biological_process +def: "The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct." [GOC:dph, PMID:20614624] +is_a: GO:0061009 ! common bile duct development + +[Term] +id: GO:0061013 +name: regulation of mRNA catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: regulates GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0061014 +name: positive regulation of mRNA catabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "positive regulation of mRNA decay" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0061013 ! regulation of mRNA catabolic process +is_a: GO:1903313 ! positive regulation of mRNA metabolic process +relationship: positively_regulates GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:0061015 +name: snRNA import into nucleus +namespace: biological_process +def: "The directed movement of snRNA, small nuclear ribonucleic acid into the nucleus." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0006404 ! RNA import into nucleus +is_a: GO:0051030 ! snRNA transport + +[Term] +id: GO:0061016 +name: snRNA localization to Cajal body +namespace: biological_process +def: "The directed movement of snRNA, small nuclear ribonucleic acid, to a Cajal body." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090670 ! RNA localization to Cajal body + +[Term] +id: GO:0061017 +name: hepatoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes." [GOC:dph, PMID:15226394] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0048863 ! stem cell differentiation +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0061024 +name: membrane organization +namespace: biological_process +alt_id: GO:0016044 +alt_id: GO:0044802 +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_pir +subset: goslim_pombe +synonym: "cellular membrane organisation" EXACT [] +synonym: "cellular membrane organization" EXACT [] +synonym: "membrane organisation" EXACT [GOC:mah] +synonym: "membrane organization and biogenesis" RELATED [GOC:mah] +synonym: "single-organism membrane organization" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0061025 +name: membrane fusion +namespace: biological_process +alt_id: GO:0006944 +alt_id: GO:0044801 +def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] +subset: goslim_yeast +synonym: "cellular membrane fusion" EXACT [] +synonym: "single-organism membrane fusion" RELATED [] +xref: Wikipedia:Lipid_bilayer_fusion +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0061026 +name: cardiac muscle tissue regeneration +namespace: biological_process +def: "The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:dph] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0061027 +name: umbilical cord development +namespace: biological_process +def: "The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:dph] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0061028 +name: establishment of endothelial barrier +namespace: biological_process +def: "The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:dph] +is_a: GO:0001885 ! endothelial cell development + +[Term] +id: GO:0061029 +name: eyelid development in camera-type eye +namespace: biological_process +def: "The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0061030 +name: epithelial cell differentiation involved in mammary gland alveolus development +namespace: biological_process +def: "The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus." [GOC:dph, GOC:yaf] +is_a: GO:0060644 ! mammary gland epithelial cell differentiation +relationship: part_of GO:0060749 ! mammary gland alveolus development + +[Term] +id: GO:0061031 +name: endodermal digestive tract morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm." [GOC:dph, GOC:yaf] +is_a: GO:0048546 ! digestive tract morphogenesis + +[Term] +id: GO:0061032 +name: visceral serous pericardium development +namespace: biological_process +def: "The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium." [GOC:dph, GOC:yaf] +synonym: "epicardium development" EXACT [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060039 ! pericardium development + +[Term] +id: GO:0061033 +name: secretion by lung epithelial cell involved in lung growth +namespace: biological_process +def: "The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development." [GOC:dph] +synonym: "fetal lung liquid secretion" RELATED [GOC:dph] +is_a: GO:0032940 ! secretion by cell +relationship: part_of GO:0060437 ! lung growth + +[Term] +id: GO:0061034 +name: olfactory bulb mitral cell layer development +namespace: biological_process +def: "The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0061035 +name: regulation of cartilage development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0051216 ! cartilage development + +[Term] +id: GO:0061036 +name: positive regulation of cartilage development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0061035 ! regulation of cartilage development +relationship: positively_regulates GO:0051216 ! cartilage development + +[Term] +id: GO:0061037 +name: negative regulation of cartilage development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [GOC:dph] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0061035 ! regulation of cartilage development +relationship: negatively_regulates GO:0051216 ! cartilage development + +[Term] +id: GO:0061038 +name: uterus morphogenesis +namespace: biological_process +def: "The process in which anatomical structures of the uterus are generated and organized." [GOC:BHF, GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0060065 ! uterus development + +[Term] +id: GO:0061040 +name: female gonad morphogenesis +namespace: biological_process +def: "The process in which a female gonad is generated and organized." [GOC:BHF, GOC:dph] +synonym: "ovary morphogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0035262 ! gonad morphogenesis +relationship: part_of GO:0008585 ! female gonad development + +[Term] +id: GO:0061041 +name: regulation of wound healing +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF, GOC:dph] +is_a: GO:1903034 ! regulation of response to wounding +relationship: regulates GO:0042060 ! wound healing + +[Term] +id: GO:0061042 +name: vascular wound healing +namespace: biological_process +def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] +is_a: GO:0060055 ! angiogenesis involved in wound healing + +[Term] +id: GO:0061043 +name: regulation of vascular wound healing +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:dph] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:0061041 ! regulation of wound healing +relationship: regulates GO:0061042 ! vascular wound healing + +[Term] +id: GO:0061044 +name: negative regulation of vascular wound healing +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." [GOC:BHF, GOC:dph] +is_a: GO:0016525 ! negative regulation of angiogenesis +is_a: GO:0061043 ! regulation of vascular wound healing +is_a: GO:0061045 ! negative regulation of wound healing +relationship: negatively_regulates GO:0061042 ! vascular wound healing + +[Term] +id: GO:0061045 +name: negative regulation of wound healing +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:dph] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0061041 ! regulation of wound healing +is_a: GO:1903035 ! negative regulation of response to wounding +relationship: negatively_regulates GO:0042060 ! wound healing + +[Term] +id: GO:0061046 +name: regulation of branching involved in lung morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0061047 +name: positive regulation of branching involved in lung morphogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0061048 +name: negative regulation of branching involved in lung morphogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units." [GOC:dph, GOC:yaf] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0061046 ! regulation of branching involved in lung morphogenesis +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0060441 ! epithelial tube branching involved in lung morphogenesis + +[Term] +id: GO:0061049 +name: cell growth involved in cardiac muscle cell development +namespace: biological_process +def: "The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] +synonym: "cardiac muscle cell hypertrophy" RELATED [GOC:dph] +synonym: "cardiomyocyte growth" RELATED [GOC:dph] +synonym: "heart muscle cell growth" RELATED [GOC:dph] +is_a: GO:0048588 ! developmental cell growth +relationship: part_of GO:0003301 ! physiological cardiac muscle hypertrophy +relationship: part_of GO:0055013 ! cardiac muscle cell development + +[Term] +id: GO:0061050 +name: regulation of cell growth involved in cardiac muscle cell development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0055021 ! regulation of cardiac muscle tissue growth +relationship: regulates GO:0061049 ! cell growth involved in cardiac muscle cell development + +[Term] +id: GO:0061051 +name: positive regulation of cell growth involved in cardiac muscle cell development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] +is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation +is_a: GO:0055023 ! positive regulation of cardiac muscle tissue growth +is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development +relationship: positively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development + +[Term] +id: GO:0061052 +name: negative regulation of cell growth involved in cardiac muscle cell development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state." [GOC:dph] +is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation +is_a: GO:0055022 ! negative regulation of cardiac muscle tissue growth +is_a: GO:0061050 ! regulation of cell growth involved in cardiac muscle cell development +relationship: negatively_regulates GO:0061049 ! cell growth involved in cardiac muscle cell development + +[Term] +id: GO:0061053 +name: somite development +namespace: biological_process +def: "The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:dph] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0061054 +name: dermatome development +namespace: biological_process +def: "The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061053 ! somite development + +[Term] +id: GO:0061055 +name: myotome development +namespace: biological_process +def: "The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061053 ! somite development + +[Term] +id: GO:0061056 +name: sclerotome development +namespace: biological_process +def: "The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0061053 ! somite development + +[Term] +id: GO:0061057 +name: peptidoglycan recognition protein signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides." [GOC:dph, PMID:18688280] +synonym: "Imd signaling pathway" EXACT [GOC:dph] +synonym: "Imd signalling pathway" EXACT [GOC:dph] +synonym: "immune deficiency pathway" RELATED [GOC:dph] +synonym: "immune deficiency signaling pathway" RELATED [GOC:dph] +synonym: "PGRP signaling pathway" RELATED [GOC:dph] +is_a: GO:0002764 ! immune response-regulating signaling pathway +relationship: part_of GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0061058 +name: regulation of peptidoglycan recognition protein signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] +synonym: "regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway + +[Term] +id: GO:0061059 +name: positive regulation of peptidoglycan recognition protein signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] +synonym: "positive regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway +is_a: GO:1900426 ! positive regulation of defense response to bacterium +relationship: positively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway + +[Term] +id: GO:0061060 +name: negative regulation of peptidoglycan recognition protein signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway." [GOC:dph] +synonym: "negative regulation of peptidoglycan recognition protein signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0061058 ! regulation of peptidoglycan recognition protein signaling pathway +is_a: GO:1900425 ! negative regulation of defense response to bacterium +relationship: negatively_regulates GO:0061057 ! peptidoglycan recognition protein signaling pathway + +[Term] +id: GO:0061061 +name: muscle structure development +namespace: biological_process +def: "The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms." [GOC:dph] +subset: goslim_drosophila +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0061062 +name: regulation of nematode larval development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0002119 ! nematode larval development + +[Term] +id: GO:0061063 +name: positive regulation of nematode larval development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0061062 ! regulation of nematode larval development +relationship: positively_regulates GO:0002119 ! nematode larval development + +[Term] +id: GO:0061064 +name: negative regulation of nematode larval development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:dph, GOC:kmv] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0061062 ! regulation of nematode larval development +relationship: negatively_regulates GO:0002119 ! nematode larval development + +[Term] +id: GO:0061065 +name: regulation of dauer larval development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] +is_a: GO:0061062 ! regulation of nematode larval development +relationship: regulates GO:0040024 ! dauer larval development + +[Term] +id: GO:0061066 +name: positive regulation of dauer larval development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] +is_a: GO:0061063 ! positive regulation of nematode larval development +is_a: GO:0061065 ! regulation of dauer larval development +relationship: positively_regulates GO:0040024 ! dauer larval development + +[Term] +id: GO:0061067 +name: negative regulation of dauer larval development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:dph, GOC:kmv] +is_a: GO:0061064 ! negative regulation of nematode larval development +is_a: GO:0061065 ! regulation of dauer larval development +relationship: negatively_regulates GO:0040024 ! dauer larval development + +[Term] +id: GO:0061068 +name: urethra development +namespace: biological_process +def: "The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body." [GOC:dph] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0061069 +name: male urethra development +namespace: biological_process +def: "The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body." [GOC:dph] +is_a: GO:0061068 ! urethra development + +[Term] +id: GO:0061070 +name: female urethra development +namespace: biological_process +def: "The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening." [GOC:dph] +is_a: GO:0061068 ! urethra development + +[Term] +id: GO:0061071 +name: urethra epithelium development +namespace: biological_process +def: "The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes." [GOC:dph] +is_a: GO:0035295 ! tube development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0061068 ! urethra development + +[Term] +id: GO:0061072 +name: iris morphogenesis +namespace: biological_process +def: "The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0061073 +name: ciliary body morphogenesis +namespace: biological_process +def: "The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0048593 ! camera-type eye morphogenesis + +[Term] +id: GO:0061074 +name: regulation of neural retina development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0003407 ! neural retina development + +[Term] +id: GO:0061075 +name: positive regulation of neural retina development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] +is_a: GO:0061074 ! regulation of neural retina development +is_a: GO:1902868 ! positive regulation of retina development in camera-type eye +relationship: positively_regulates GO:0003407 ! neural retina development + +[Term] +id: GO:0061076 +name: negative regulation of neural retina development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:dph] +is_a: GO:0061074 ! regulation of neural retina development +is_a: GO:1902867 ! negative regulation of retina development in camera-type eye +relationship: negatively_regulates GO:0003407 ! neural retina development + +[Term] +id: GO:0061077 +name: chaperone-mediated protein folding +namespace: biological_process +def: "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone." [GOC:dph, GOC:vw] +is_a: GO:0006457 ! protein folding + +[Term] +id: GO:0061078 +name: positive regulation of prostaglandin secretion involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell and contributes to the immune response." [GOC:BHF, GOC:dph] +synonym: "positive regulation of prostaglandin secretion during immune response" RELATED [GOC:dph] +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0032308 ! positive regulation of prostaglandin secretion +relationship: positively_regulates GO:0090323 ! prostaglandin secretion involved in immune response + +[Term] +id: GO:0061079 +name: left horn of sinus venosus development +namespace: biological_process +def: "The progression of the left horn of the sinus venosus from its initial formation to the mature structure." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0003235 ! sinus venosus development + +[Term] +id: GO:0061080 +name: right horn of sinus venosus development +namespace: biological_process +def: "The progression of the right horn of the sinus venosus from its formation to the mature structure." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0003235 ! sinus venosus development + +[Term] +id: GO:0061081 +name: positive regulation of myeloid leukocyte cytokine production involved in immune response +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response." [GOC:BHF, GOC:dph] +synonym: "positive regulation of myeloid cell cytokine production involved in immune response" RELATED [GOC:dph] +is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response +relationship: positively_regulates GO:0061082 ! myeloid leukocyte cytokine production + +[Term] +id: GO:0061082 +name: myeloid leukocyte cytokine production +namespace: biological_process +def: "Any process that contributes to cytokine production by a myeloid cell." [GOC:dph] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002367 ! cytokine production involved in immune response + +[Term] +id: GO:0061083 +name: regulation of protein refolding +namespace: biological_process +def: "Any process that regulates the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:dph, GOC:tb] +is_a: GO:1903332 ! regulation of protein folding +relationship: regulates GO:0042026 ! protein refolding + +[Term] +id: GO:0061084 +name: negative regulation of protein refolding +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein refolding. Protein refolding is the process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0061083 ! regulation of protein refolding +is_a: GO:1903333 ! negative regulation of protein folding +relationship: negatively_regulates GO:0042026 ! protein refolding + +[Term] +id: GO:0061085 +name: regulation of histone H3-K27 methylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0070734 ! histone H3-K27 methylation + +[Term] +id: GO:0061086 +name: negative regulation of histone H3-K27 methylation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0061085 ! regulation of histone H3-K27 methylation +relationship: negatively_regulates GO:0070734 ! histone H3-K27 methylation + +[Term] +id: GO:0061087 +name: positive regulation of histone H3-K27 methylation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone." [GOC:dph, GOC:tb] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0061085 ! regulation of histone H3-K27 methylation +relationship: positively_regulates GO:0070734 ! histone H3-K27 methylation + +[Term] +id: GO:0061088 +name: regulation of sequestering of zinc ion +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0050801 ! ion homeostasis +relationship: regulates GO:0032119 ! sequestering of zinc ion + +[Term] +id: GO:0061089 +name: negative regulation of sequestering of zinc ion +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0061088 ! regulation of sequestering of zinc ion +relationship: negatively_regulates GO:0032119 ! sequestering of zinc ion + +[Term] +id: GO:0061090 +name: positive regulation of sequestering of zinc ion +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0061088 ! regulation of sequestering of zinc ion +relationship: positively_regulates GO:0032119 ! sequestering of zinc ion + +[Term] +id: GO:0061091 +name: regulation of phospholipid translocation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0097035 ! regulation of membrane lipid distribution +is_a: GO:2001138 ! regulation of phospholipid transport +relationship: regulates GO:0045332 ! phospholipid translocation + +[Term] +id: GO:0061092 +name: positive regulation of phospholipid translocation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0061091 ! regulation of phospholipid translocation +is_a: GO:2001140 ! positive regulation of phospholipid transport +relationship: positively_regulates GO:0045332 ! phospholipid translocation + +[Term] +id: GO:0061093 +name: negative regulation of phospholipid translocation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." [GOC:dph, GOC:jh, GOC:tb, PMID:19966303] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0061091 ! regulation of phospholipid translocation +is_a: GO:2001139 ! negative regulation of phospholipid transport +relationship: negatively_regulates GO:0045332 ! phospholipid translocation + +[Term] +id: GO:0061094 +name: regulation of turning behavior involved in mating +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] +is_a: GO:1902435 ! regulation of male mating behavior +relationship: regulates GO:0034607 ! turning behavior involved in mating + +[Term] +id: GO:0061095 +name: positive regulation of turning behavior involved in mating +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] +is_a: GO:0061094 ! regulation of turning behavior involved in mating +is_a: GO:1902437 ! positive regulation of male mating behavior +relationship: positively_regulates GO:0034607 ! turning behavior involved in mating + +[Term] +id: GO:0061096 +name: negative regulation of turning behavior involved in mating +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of turning behavior involved in mating. Turning behavior is the sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail." [GOC:dph, GOC:tb] +is_a: GO:0061094 ! regulation of turning behavior involved in mating +is_a: GO:1902436 ! negative regulation of male mating behavior +relationship: negatively_regulates GO:0034607 ! turning behavior involved in mating + +[Term] +id: GO:0061097 +name: regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0045859 ! regulation of protein kinase activity +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation + +[Term] +id: GO:0061098 +name: positive regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity + +[Term] +id: GO:0061099 +name: negative regulation of protein tyrosine kinase activity +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity." [GOC:dph, GOC:tb] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity + +[Term] +id: GO:0061100 +name: lung neuroendocrine cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium." [GOC:dph, PMID:9126746] +is_a: GO:0061101 ! neuroendocrine cell differentiation +is_a: GO:0061140 ! lung secretory cell differentiation + +[Term] +id: GO:0061101 +name: neuroendocrine cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance." [GOC:dph] +is_a: GO:0060563 ! neuroepithelial cell differentiation + +[Term] +id: GO:0061102 +name: stomach neuroendocrine cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium." [GOC:dph, PMID:18173746] +synonym: "gastric neuroendocrine cell differentiation" RELATED [GOC:dph] +is_a: GO:0061101 ! neuroendocrine cell differentiation +relationship: part_of GO:0062094 ! stomach development + +[Term] +id: GO:0061103 +name: carotid body glomus cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia." [GOC:dph, PMID:6243386] +is_a: GO:0061101 ! neuroendocrine cell differentiation +relationship: part_of GO:0048513 ! animal organ development + +[Term] +id: GO:0061104 +name: adrenal chromaffin cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles." [GOC:dph] +is_a: GO:0002067 ! glandular epithelial cell differentiation +is_a: GO:0061101 ! neuroendocrine cell differentiation +relationship: part_of GO:0030325 ! adrenal gland development + +[Term] +id: GO:0061105 +name: regulation of stomach neuroendocrine cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0061102 ! stomach neuroendocrine cell differentiation + +[Term] +id: GO:0061106 +name: negative regulation of stomach neuroendocrine cell differentiation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach." [GOC:dph] +is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation +is_a: GO:0061105 ! regulation of stomach neuroendocrine cell differentiation +relationship: negatively_regulates GO:0061102 ! stomach neuroendocrine cell differentiation + +[Term] +id: GO:0061107 +name: seminal vesicle development +namespace: biological_process +def: "The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen." [GOC:dph] +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0061108 +name: seminal vesicle epithelium development +namespace: biological_process +def: "The progression of the seminal vesicle epithelium over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0035295 ! tube development +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0061107 ! seminal vesicle development + +[Term] +id: GO:0061109 +name: dense core granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] +synonym: "dense core granule organisation" EXACT [GOC:mah] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0061110 +name: dense core granule biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule." [GOC:dph] +is_a: GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0061111 +name: epithelial-mesenchymal cell signaling involved in lung development +namespace: biological_process +def: "Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell and contributes to the progression of the lung over time from its initial formation to the mature organ." [GOC:dph] +synonym: "epithelial-mesenchymal cell signalling involved in lung development" EXACT [GOC:mah] +is_a: GO:0060495 ! cell-cell signaling involved in lung development +is_a: GO:0060684 ! epithelial-mesenchymal cell signaling + +[Term] +id: GO:0061112 +name: negative regulation of bud outgrowth involved in lung branching +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching." [GOC:dph] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0061048 ! negative regulation of branching involved in lung morphogenesis +relationship: negatively_regulates GO:0060447 ! bud outgrowth involved in lung branching + +[Term] +id: GO:0061113 +name: pancreas morphogenesis +namespace: biological_process +def: "Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized." [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0031016 ! pancreas development + +[Term] +id: GO:0061114 +name: branching involved in pancreas morphogenesis +namespace: biological_process +def: "The process in which the branches of the pancreas are generated and organized." [GOC:dph] +is_a: GO:0061138 ! morphogenesis of a branching epithelium +relationship: part_of GO:0061113 ! pancreas morphogenesis + +[Term] +id: GO:0061115 +name: lung proximal/distal axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli." [GOC:dph] +is_a: GO:0009946 ! proximal/distal axis specification +is_a: GO:0060432 ! lung pattern specification process + +[Term] +id: GO:0061116 +name: ductus venosus closure +namespace: biological_process +def: "The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth." [GOC:dph] +is_a: GO:0048845 ! venous blood vessel morphogenesis + +[Term] +id: GO:0061117 +name: negative regulation of heart growth +namespace: biological_process +def: "Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." [GOC:dph, GOC:hjd] +is_a: GO:0046621 ! negative regulation of organ growth +is_a: GO:0060420 ! regulation of heart growth +relationship: negatively_regulates GO:0060419 ! heart growth + +[Term] +id: GO:0061118 +name: regulation of positive chemotaxis to cAMP +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] +is_a: GO:0050926 ! regulation of positive chemotaxis +relationship: regulates GO:0043327 ! chemotaxis to cAMP + +[Term] +id: GO:0061119 +name: regulation of positive chemotaxis to cAMP by chlorinated alkylphenone +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph, PMID:19684855] +is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP + +[Term] +id: GO:0061120 +name: regulation of positive chemotaxis to cAMP by DIF-1 +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061121 +name: regulation of positive chemotaxis to cAMP by DIF-2 +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061122 +name: positive regulation of positive chemotaxis to cAMP +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] +is_a: GO:0050927 ! positive regulation of positive chemotaxis +is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP +relationship: positively_regulates GO:0043327 ! chemotaxis to cAMP + +[Term] +id: GO:0061123 +name: negative regulation of positive chemotaxis to cAMP +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP." [GOC:dph] +is_a: GO:0050928 ! negative regulation of positive chemotaxis +is_a: GO:0061118 ! regulation of positive chemotaxis to cAMP +relationship: negatively_regulates GO:0043327 ! chemotaxis to cAMP + +[Term] +id: GO:0061124 +name: positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] +is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone +is_a: GO:0061122 ! positive regulation of positive chemotaxis to cAMP + +[Term] +id: GO:0061125 +name: negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions." [GOC:dph] +is_a: GO:0061119 ! regulation of positive chemotaxis to cAMP by chlorinated alkylphenone +is_a: GO:0061123 ! negative regulation of positive chemotaxis to cAMP + +[Term] +id: GO:0061126 +name: positive regulation of positive chemotaxis to cAMP by DIF-1 +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 +is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061127 +name: negative regulation of positive chemotaxis to cAMP by DIF-1 +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061120 ! regulation of positive chemotaxis to cAMP by DIF-1 +is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061128 +name: positive regulation of chemotaxis to cAMP by DIF-2 +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 +is_a: GO:0061124 ! positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061129 +name: negative regulation of positive chemotaxis to cAMP by DIF-2 +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone." [GOC:dph] +is_a: GO:0061121 ! regulation of positive chemotaxis to cAMP by DIF-2 +is_a: GO:0061125 ! negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone + +[Term] +id: GO:0061130 +name: pancreatic bud formation +namespace: biological_process +def: "The morphogenetic process in which the foregut region specified to become the pancreas forms a bud." [GOC:dph] +is_a: GO:0048645 ! animal organ formation +is_a: GO:0061114 ! branching involved in pancreas morphogenesis +is_a: GO:0072175 ! epithelial tube formation + +[Term] +id: GO:0061131 +name: pancreas field specification +namespace: biological_process +def: "The process in which a specific region of the gut is delineated into the area in which the pancreas will develop." [GOC:dph] +is_a: GO:0010092 ! specification of animal organ identity +relationship: part_of GO:0061130 ! pancreatic bud formation + +[Term] +id: GO:0061132 +name: pancreas induction +namespace: biological_process +def: "The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas." [GOC:dph] +is_a: GO:0001759 ! organ induction +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905278 ! positive regulation of epithelial tube formation +relationship: positively_regulates GO:0061131 ! pancreas field specification + +[Term] +id: GO:0061133 +name: endopeptidase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] +is_a: GO:0016504 ! peptidase activator activity +is_a: GO:0061135 ! endopeptidase regulator activity + +[Term] +id: GO:0061134 +name: peptidase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:dph, GOC:tb] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0061135 +name: endopeptidase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:dph, GOC:tb] +is_a: GO:0061134 ! peptidase regulator activity + +[Term] +id: GO:0061136 +name: regulation of proteasomal protein catabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] +is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process +relationship: regulates GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0061137 +name: bud dilation +namespace: biological_process +def: "The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch." [GOC:dph] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0001763 ! morphogenesis of a branching structure + +[Term] +id: GO:0061138 +name: morphogenesis of a branching epithelium +namespace: biological_process +def: "The process in which the anatomical structures of a branched epithelium are generated and organized." [GOC:dph] +is_a: GO:0001763 ! morphogenesis of a branching structure +is_a: GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:0061139 +name: bud field specification +namespace: biological_process +def: "The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:dph] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0061138 ! morphogenesis of a branching epithelium + +[Term] +id: GO:0061140 +name: lung secretory cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part." [GOC:dph] +is_a: GO:0060487 ! lung epithelial cell differentiation + +[Term] +id: GO:0061141 +name: lung ciliated cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells." [GOC:cilia, GOC:dph, GOC:krc] +is_a: GO:0060487 ! lung epithelial cell differentiation + +[Term] +id: GO:0061142 +name: mesothelial-mesenchymal cell signaling involved in early lung development +namespace: biological_process +def: "Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung." [GOC:dph] +synonym: "mesothelial-mesenchymal cell signalling involved in early lung development" EXACT [GOC:mah] +is_a: GO:0060495 ! cell-cell signaling involved in lung development + +[Term] +id: GO:0061143 +name: alveolar primary septum development +namespace: biological_process +def: "The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms." [GOC:dph] +is_a: GO:0060428 ! lung epithelium development +relationship: part_of GO:0060430 ! lung saccule development + +[Term] +id: GO:0061144 +name: alveolar secondary septum development +namespace: biological_process +def: "The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule." [GOC:dph] +is_a: GO:0060428 ! lung epithelium development +relationship: part_of GO:0060430 ! lung saccule development + +[Term] +id: GO:0061145 +name: lung smooth muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0048745 ! smooth muscle tissue development +relationship: part_of GO:0030324 ! lung development + +[Term] +id: GO:0061146 +name: Peyer's patch morphogenesis +namespace: biological_process +def: "The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:dph] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0048541 ! Peyer's patch development + +[Term] +id: GO:0061147 +name: endocardial endothelium development +namespace: biological_process +def: "The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] +is_a: GO:0003158 ! endothelium development +relationship: part_of GO:0003157 ! endocardium development + +[Term] +id: GO:0061148 +name: extracellular matrix organization involved in endocardium development +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:dph] +synonym: "extracellular matrix organisation involved in endocardium development" EXACT [GOC:mah] +is_a: GO:0030198 ! extracellular matrix organization +relationship: part_of GO:0003157 ! endocardium development + +[Term] +id: GO:0061149 +name: BMP signaling pathway involved in ureter morphogenesis +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder." [GOC:dph, GOC:mtg_kidney_jan10] +synonym: "BMP signalling pathway involved in ureter morphogenesis" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0072197 ! ureter morphogenesis + +[Term] +id: GO:0061150 +name: renal system segmentation +namespace: biological_process +def: "The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis." [GOC:dph, GOC:yaf] +synonym: "urinary tract segmentation" EXACT [GOC:dph] +is_a: GO:0035282 ! segmentation +is_a: GO:0072048 ! renal system pattern specification + +[Term] +id: GO:0061151 +name: BMP signaling pathway involved in renal system segmentation +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system." [GOC:dph, GOC:yaf] +synonym: "BMP signalling pathway involved in renal system segmentation" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0061150 ! renal system segmentation + +[Term] +id: GO:0061152 +name: trachea submucosa development +namespace: biological_process +def: "The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0060438 ! trachea development + +[Term] +id: GO:0061153 +name: trachea gland development +namespace: biological_process +def: "The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection." [GOC:dph] +is_a: GO:0048732 ! gland development +relationship: part_of GO:0061152 ! trachea submucosa development + +[Term] +id: GO:0061154 +name: endothelial tube morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:dph, GOC:yaf] +is_a: GO:0003159 ! morphogenesis of an endothelium +is_a: GO:0060562 ! epithelial tube morphogenesis + +[Term] +id: GO:0061155 +name: pulmonary artery endothelial tube morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery." [GOC:dph, GOC:yaf] +is_a: GO:0061154 ! endothelial tube morphogenesis +relationship: part_of GO:0061156 ! pulmonary artery morphogenesis + +[Term] +id: GO:0061156 +name: pulmonary artery morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs." [GOC:dph, GOC:yaf] +is_a: GO:0048844 ! artery morphogenesis + +[Term] +id: GO:0061157 +name: mRNA destabilization +namespace: biological_process +def: "Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [GOC:dph, GOC:jh] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0043488 ! regulation of mRNA stability +is_a: GO:0050779 ! RNA destabilization +is_a: GO:0061014 ! positive regulation of mRNA catabolic process + +[Term] +id: GO:0061158 +name: 3'-UTR-mediated mRNA destabilization +namespace: biological_process +def: "An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:dph, GOC:jh] +is_a: GO:0061157 ! mRNA destabilization + +[Term] +id: GO:0061159 +name: establishment of bipolar cell polarity involved in cell morphogenesis +namespace: biological_process +def: "The specification and formation of bipolar intracellular organization or cell growth patterns that contribute to cell morphogenesis. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] +is_a: GO:0061171 ! establishment of bipolar cell polarity +relationship: part_of GO:0000902 ! cell morphogenesis + +[Term] +id: GO:0061160 +name: regulation of establishment of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell." [GOC:dph, GOC:vw] +is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity +is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:0061161 +name: positive regulation of establishment of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell." [GOC:dph, GOC:vw] +is_a: GO:0061160 ! regulation of establishment of bipolar cell polarity regulating cell shape +is_a: GO:0061173 ! positive regulation of establishment of bipolar cell polarity +is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:0061162 +name: establishment of monopolar cell polarity +namespace: biological_process +def: "The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity + +[Term] +id: GO:0061163 +name: endoplasmic reticulum polarization +namespace: biological_process +alt_id: GO:0061164 +alt_id: GO:0061165 +alt_id: GO:0061166 +alt_id: GO:0061167 +def: "The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity." [GOC:dph, GOC:vw] +synonym: "endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" NARROW [GOC:mah] +synonym: "endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site" NARROW [] +synonym: "ER localization involved in ER polarization at cell division site" NARROW [GOC:dph] +synonym: "ER polarization" EXACT [] +synonym: "establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site" NARROW [GOC:mah] +synonym: "establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site" NARROW [] +synonym: "maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site" NARROW [] +synonym: "transitional endoplasmic reticulum polarization at cell division site" NARROW [] +is_a: GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0061168 +name: regulation of hair follicle placode formation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0060789 ! hair follicle placode formation + +[Term] +id: GO:0061169 +name: positive regulation of hair placode formation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0061168 ! regulation of hair follicle placode formation +relationship: positively_regulates GO:0060789 ! hair follicle placode formation + +[Term] +id: GO:0061170 +name: negative regulation of hair follicle placode formation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud." [GOC:dph] +is_a: GO:0051799 ! negative regulation of hair follicle development +is_a: GO:0061168 ! regulation of hair follicle placode formation +relationship: negatively_regulates GO:0060789 ! hair follicle placode formation + +[Term] +id: GO:0061171 +name: establishment of bipolar cell polarity +namespace: biological_process +def: "The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] +is_a: GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:0061172 +name: regulation of establishment of bipolar cell polarity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane." [GOC:dph, GOC:vw] +is_a: GO:2000114 ! regulation of establishment of cell polarity +relationship: regulates GO:0061171 ! establishment of bipolar cell polarity + +[Term] +id: GO:0061173 +name: positive regulation of establishment of bipolar cell polarity +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity." [GOC:dph, GOC:vw] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity +relationship: positively_regulates GO:0061171 ! establishment of bipolar cell polarity + +[Term] +id: GO:0061174 +name: type I terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] +synonym: "type I terminal button" EXACT [GOC:dph] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:0061175 +name: type II terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc] +synonym: "type II terminal button" EXACT [GOC:dph] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:0061176 +name: type Ib terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons." [GOC:dph, GOC:mc] +synonym: "type Ib terminal button" EXACT [GOC:dph] +is_a: GO:0061174 ! type I terminal bouton + +[Term] +id: GO:0061177 +name: type Is terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons." [GOC:dph, GOC:mc] +synonym: "type Is terminal button" RELATED [GOC:dph] +is_a: GO:0061174 ! type I terminal bouton + +[Term] +id: GO:0061178 +name: regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] +synonym: "regulation of insulin secretion in response to glucose" EXACT [GOC:dph] +is_a: GO:0050796 ! regulation of insulin secretion +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus + +[Term] +id: GO:0061179 +name: negative regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose." [GOC:BHF, GOC:dph] +synonym: "negative regulation of insulin secretion in response to glucose" RELATED [GOC:dph] +synonym: "negative regulation of insulin secretion involved in cellular response to glucose" EXACT [GOC:bf] +is_a: GO:0046676 ! negative regulation of insulin secretion +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0061178 ! regulation of insulin secretion involved in cellular response to glucose stimulus +relationship: negatively_regulates GO:0035773 ! insulin secretion involved in cellular response to glucose stimulus + +[Term] +id: GO:0061180 +name: mammary gland epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk." [GOC:dph, GOC:yaf] +synonym: "breast epithelium development" EXACT [GOC:dph] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0061181 +name: regulation of chondrocyte development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0002063 ! chondrocyte development + +[Term] +id: GO:0061182 +name: negative regulation of chondrocyte development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:BHF, GOC:dph] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0032331 ! negative regulation of chondrocyte differentiation +is_a: GO:0061181 ! regulation of chondrocyte development +relationship: negatively_regulates GO:0002063 ! chondrocyte development + +[Term] +id: GO:0061183 +name: regulation of dermatome development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0061054 ! dermatome development + +[Term] +id: GO:0061184 +name: positive regulation of dermatome development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] +is_a: GO:0040019 ! positive regulation of embryonic development +is_a: GO:0061183 ! regulation of dermatome development +relationship: positively_regulates GO:0061054 ! dermatome development + +[Term] +id: GO:0061185 +name: negative regulation of dermatome development +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin." [GOC:BHF, GOC:dph] +is_a: GO:0045992 ! negative regulation of embryonic development +is_a: GO:0061183 ! regulation of dermatome development +relationship: negatively_regulates GO:0061054 ! dermatome development + +[Term] +id: GO:0061186 +name: negative regulation of silent mating-type cassette heterochromatin assembly +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, PMID:10388812] +synonym: "negative regulation of chromatin silencing at silent mating-type cassette" EXACT [] +is_a: GO:0031452 ! negative regulation of heterochromatin assembly +is_a: GO:0090054 ! regulation of silent mating-type cassette heterochromatin assembly +relationship: negatively_regulates GO:0030466 ! silent mating-type cassette heterochromatin assembly + +[Term] +id: GO:0061187 +name: regulation of ribosomal DNA heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the repression of assembly of rDNA heterochromatin." [GOC:dph, PMID:10388812] +synonym: "regulation of chromatin silencing at rDNA" BROAD [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0000183 ! rDNA heterochromatin assembly + +[Term] +id: GO:0061188 +name: negative regulation of ribosomal DNA heterochromatin assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the repression of assembly of rDNA heterochromatin." [GOC:dph, PMID:10388812] +synonym: "negative regulation of chromatin silencing at rDNA" BROAD [] +is_a: GO:0031452 ! negative regulation of heterochromatin assembly +is_a: GO:0061187 ! regulation of ribosomal DNA heterochromatin assembly +relationship: negatively_regulates GO:0000183 ! rDNA heterochromatin assembly + +[Term] +id: GO:0061189 +name: positive regulation of sclerotome development +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:BHF, GOC:dph] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0061190 ! regulation of sclerotome development +relationship: positively_regulates GO:0061056 ! sclerotome development + +[Term] +id: GO:0061190 +name: regulation of sclerotome development +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra." [GOC:dph] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0061056 ! sclerotome development + +[Term] +id: GO:0061191 +name: positive regulation of vacuole fusion, non-autophagic +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] +is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic +is_a: GO:0044090 ! positive regulation of vacuole organization +relationship: positively_regulates GO:0042144 ! vacuole fusion, non-autophagic + +[Term] +id: GO:0061192 +name: negative regulation of vacuole fusion, non-autophagic +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:dph] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0032889 ! regulation of vacuole fusion, non-autophagic +relationship: negatively_regulates GO:0042144 ! vacuole fusion, non-autophagic + +[Term] +id: GO:0061193 +name: taste bud development +namespace: biological_process +def: "The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] +is_a: GO:0007423 ! sensory organ development +relationship: part_of GO:0043586 ! tongue development + +[Term] +id: GO:0061194 +name: taste bud morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] +is_a: GO:0090596 ! sensory organ morphogenesis +relationship: part_of GO:0043587 ! tongue morphogenesis +relationship: part_of GO:0061193 ! taste bud development + +[Term] +id: GO:0061195 +name: taste bud formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors." [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0061194 ! taste bud morphogenesis + +[Term] +id: GO:0061196 +name: fungiform papilla development +namespace: biological_process +def: "The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043586 ! tongue development + +[Term] +id: GO:0061197 +name: fungiform papilla morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0043587 ! tongue morphogenesis +relationship: part_of GO:0061196 ! fungiform papilla development + +[Term] +id: GO:0061198 +name: fungiform papilla formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue." [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0061197 ! fungiform papilla morphogenesis + +[Term] +id: GO:0061199 +name: striated muscle contraction involved in embryonic body morphogenesis +namespace: biological_process +def: "The process in which force is generated within striated embryonic muscle tissue, resulting in a contraction of the muscle that contributes to the formation of an embryo's characteristic body morphology." [GOC:dph, GOC:kmv] +is_a: GO:0006941 ! striated muscle contraction +relationship: part_of GO:0010172 ! embryonic body morphogenesis + +[Term] +id: GO:0061200 +name: clathrin-sculpted gamma-aminobutyric acid transport vesicle +namespace: cellular_component +def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle." [GOC:dph] +synonym: "clathrin sculpted GABA transport vesicle" EXACT [GOC:dph] +synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle" EXACT [GOC:sl] +is_a: GO:0060198 ! clathrin-sculpted vesicle + +[Term] +id: GO:0061201 +name: clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] +synonym: "clathrin sculpted GABA transport vesicle lumen" EXACT [GOC:dph] +synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle lumen" EXACT [GOC:sl] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle + +[Term] +id: GO:0061202 +name: clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle." [GOC:dph] +synonym: "clathrin sculpted GABA transport vesicle membrane" EXACT [GOC:dph] +synonym: "clathrin sculpted gamma-aminobutyric acid transport vesicle membrane" EXACT [GOC:sl] +is_a: GO:0030665 ! clathrin-coated vesicle membrane +relationship: part_of GO:0061200 ! clathrin-sculpted gamma-aminobutyric acid transport vesicle + +[Term] +id: GO:0061203 +name: striated muscle paramyosin thick filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle." [GOC:dph, GOC:kmv] +is_a: GO:0061204 ! paramyosin filament assembly or disassembly +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0061204 +name: paramyosin filament assembly or disassembly +namespace: biological_process +def: "The formation or disassembly of a filament composed of paramyosin molecules." [GOC:dph, GOC:kmv] +is_a: GO:0030036 ! actin cytoskeleton organization + +[Term] +id: GO:0061205 +name: paramesonephric duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin." [GOC:dph, GOC:yaf] +synonym: "Mullerian duct development" EXACT [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0035295 ! tube development + +[Term] +id: GO:0061206 +name: mesonephros morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephros are generated and organized." [GOC:mtg_kidney_jan10] +synonym: "Wolffian body morphogenesis" EXACT [GOC:dph] +is_a: GO:0060993 ! kidney morphogenesis +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061207 +name: mesonephric juxtaglomerulus cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072052 ! juxtaglomerulus cell differentiation +relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development + +[Term] +id: GO:0061208 +name: cell differentiation involved in mesonephros development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061209 +name: cell proliferation involved in mesonephros development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061210 +name: cell-cell signaling involved in mesonephros development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mesonephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] +synonym: "cell-cell signalling involved in mesonephros development" EXACT [GOC:mah] +is_a: GO:0060995 ! cell-cell signaling involved in kidney development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061211 +name: mesonephric collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] +is_a: GO:0072044 ! collecting duct development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061212 +name: mesonephric juxtaglomerular apparatus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] +is_a: GO:0072051 ! juxtaglomerular apparatus development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061213 +name: positive regulation of mesonephros development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0061217 ! regulation of mesonephros development +is_a: GO:0090184 ! positive regulation of kidney development +relationship: positively_regulates GO:0001823 ! mesonephros development + +[Term] +id: GO:0061214 +name: mesonephric smooth muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072194 ! kidney smooth muscle tissue development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061215 +name: mesonephric nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0072006 ! nephron development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061216 +name: regulation of transcription from RNA polymerase II promoter involved in mesonephros development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the mesonephros progressing from its initial formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061217 +name: regulation of mesonephros development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0090183 ! regulation of kidney development +relationship: regulates GO:0001823 ! mesonephros development + +[Term] +id: GO:0061218 +name: negative regulation of mesonephros development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0061217 ! regulation of mesonephros development +is_a: GO:0090185 ! negative regulation of kidney development +relationship: negatively_regulates GO:0001823 ! mesonephros development + +[Term] +id: GO:0061219 +name: mesonephric mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072074 ! kidney mesenchyme development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061220 +name: mesonephric macula densa development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0061241 ! mesonephric nephron epithelium development +is_a: GO:0072024 ! macula densa development +relationship: part_of GO:0061212 ! mesonephric juxtaglomerular apparatus development + +[Term] +id: GO:0061221 +name: mesonephric mesenchyme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072131 ! kidney mesenchyme morphogenesis +relationship: part_of GO:0061219 ! mesonephric mesenchyme development + +[Term] +id: GO:0061222 +name: mesonephric mesenchymal cell proliferation involved in mesonephros development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population." [GOC:mtg_kidney_jan10] +is_a: GO:0061209 ! cell proliferation involved in mesonephros development +is_a: GO:0072135 ! kidney mesenchymal cell proliferation +relationship: part_of GO:0061219 ! mesonephric mesenchyme development + +[Term] +id: GO:0061223 +name: mesonephric mesenchymal cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development +relationship: part_of GO:0061219 ! mesonephric mesenchyme development + +[Term] +id: GO:0061224 +name: mesonephric glomerulus development +namespace: biological_process +def: "The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0032835 ! glomerulus development +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061225 +name: mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development +namespace: biological_process +def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] +synonym: "mesonephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "mesonephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0061209 ! cell proliferation involved in mesonephros development +is_a: GO:0072122 ! extraglomerular mesangial cell proliferation +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061226 +name: proximal/distal pattern formation involved in mesonephric nephron development +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end)." [GOC:mtg_kidney_jan10] +is_a: GO:0061227 ! pattern specification involved in mesonephros development +is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061227 +name: pattern specification involved in mesonephros development +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] +synonym: "mesonephros pattern formation" RELATED [GOC:mtg_kidney_jan10] +synonym: "mesonephros pattern specification" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061228 +name: mesonephric nephron morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072028 ! nephron morphogenesis +relationship: part_of GO:0061206 ! mesonephros morphogenesis +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061229 +name: mesonephric juxtaglomerulus cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072142 ! juxtaglomerulus cell development +relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation + +[Term] +id: GO:0061230 +name: mesonephric juxtaglomerulus cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] +is_a: GO:0072150 ! juxtaglomerulus cell fate commitment +relationship: part_of GO:0061207 ! mesonephric juxtaglomerulus cell differentiation + +[Term] +id: GO:0061231 +name: mesonephric glomerulus vasculature development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072012 ! glomerulus vasculature development +relationship: part_of GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:0061232 +name: mesonephric glomerular epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0061241 ! mesonephric nephron epithelium development +is_a: GO:0072010 ! glomerular epithelium development +relationship: part_of GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:0061233 +name: mesonephric glomerular basement membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] +is_a: GO:0032836 ! glomerular basement membrane development +relationship: part_of GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:0061234 +name: mesonephric glomerulus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072102 ! glomerulus morphogenesis +relationship: part_of GO:0061224 ! mesonephric glomerulus development +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061235 +name: mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061236 +name: mesonephric comma-shaped body morphogenesis +namespace: biological_process +def: "The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072049 ! comma-shaped body morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061237 +name: convergent extension involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061238 +name: establishment of planar polarity involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "establishment of planar cell polarity involved in mesonephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] +is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061239 +name: mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061240 +name: mesonephric nephron tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072171 ! mesonephric tubule morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis +relationship: part_of GO:0061242 ! mesonephric nephron tubule development + +[Term] +id: GO:0061241 +name: mesonephric nephron epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +is_a: GO:0072163 ! mesonephric epithelium development +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061242 +name: mesonephric nephron tubule development +namespace: biological_process +def: "The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0061241 ! mesonephric nephron epithelium development +is_a: GO:0072080 ! nephron tubule development +is_a: GO:0072164 ! mesonephric tubule development + +[Term] +id: GO:0061243 +name: mesonephric renal vesicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072077 ! renal vesicle morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061244 +name: mesonephric S-shaped body morphogenesis +namespace: biological_process +def: "The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072050 ! S-shaped body morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:0061245 +name: establishment or maintenance of bipolar cell polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns." [GOC:dph, GOC:vw] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0061246 +name: establishment or maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell." [GOC:dph, GOC:vw] +is_a: GO:0061245 ! establishment or maintenance of bipolar cell polarity +is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:0061247 +name: mesonephric glomerular mesangium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072109 ! glomerular mesangium development +relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development + +[Term] +id: GO:0061248 +name: mesonephric glomerulus vasculature morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072103 ! glomerulus vasculature morphogenesis +relationship: part_of GO:0061231 ! mesonephric glomerulus vasculature development +relationship: part_of GO:0061234 ! mesonephric glomerulus morphogenesis + +[Term] +id: GO:0061249 +name: mesonephric glomerular capillary formation +namespace: biological_process +def: "The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] +is_a: GO:0072104 ! glomerular capillary formation +relationship: part_of GO:0061248 ! mesonephric glomerulus vasculature morphogenesis + +[Term] +id: GO:0061250 +name: mesonephric glomerular epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072311 ! glomerular epithelial cell differentiation +relationship: part_of GO:0061232 ! mesonephric glomerular epithelium development + +[Term] +id: GO:0061251 +name: mesonephric glomerular epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072310 ! glomerular epithelial cell development +relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation + +[Term] +id: GO:0061252 +name: mesonephric glomerular epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072314 ! glomerular epithelial cell fate commitment +relationship: part_of GO:0061250 ! mesonephric glomerular epithelial cell differentiation + +[Term] +id: GO:0061253 +name: mesonephric glomerular parietal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation +is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0061254 +name: mesonephric glomerular parietal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +is_a: GO:0061251 ! mesonephric glomerular epithelial cell development +is_a: GO:0072016 ! glomerular parietal epithelial cell development +relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0061255 +name: mesonephric glomerular parietal epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] +is_a: GO:0061252 ! mesonephric glomerular epithelial cell fate commitment +is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment +relationship: part_of GO:0061253 ! mesonephric glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0061256 +name: mesonephric glomerular visceral epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0061250 ! mesonephric glomerular epithelial cell differentiation +is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0061257 +name: mesonephric glomerular visceral epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0061251 ! mesonephric glomerular epithelial cell development +is_a: GO:0072015 ! glomerular visceral epithelial cell development +relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0061258 +name: mesonephric glomerular visceral epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0061251 ! mesonephric glomerular epithelial cell development +is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment +relationship: part_of GO:0061256 ! mesonephric glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0061259 +name: mesonephric glomerular mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061260 ! mesonephric mesangial cell differentiation +is_a: GO:0072008 ! glomerular mesangial cell differentiation +relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development + +[Term] +id: GO:0061260 +name: mesonephric mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072007 ! mesangial cell differentiation + +[Term] +id: GO:0061261 +name: mesenchymal to epithelial transition involved in mesonephros morphogenesis +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "mesonephric mesenchyme to epithelial transition" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +is_a: GO:0060231 ! mesenchymal to epithelial transition +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +relationship: part_of GO:0061206 ! mesonephros morphogenesis + +[Term] +id: GO:0061262 +name: mesonephric renal vesicle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "mesonephros formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072033 ! renal vesicle formation +relationship: part_of GO:0061243 ! mesonephric renal vesicle morphogenesis + +[Term] +id: GO:0061263 +name: mesonephric glomerular mesangial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072144 ! glomerular mesangial cell development +relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation + +[Term] +id: GO:0061264 +name: mesonephric glomerular mesangial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] +is_a: GO:0072152 ! glomerular mesangial cell fate commitment +relationship: part_of GO:0061259 ! mesonephric glomerular mesangial cell differentiation + +[Term] +id: GO:0061265 +name: mesonephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072160 ! nephron tubule epithelial cell differentiation +relationship: part_of GO:0061242 ! mesonephric nephron tubule development + +[Term] +id: GO:0061266 +name: mesonephric interstitial fibroblast differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "mesonephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072071 ! kidney interstitial fibroblast differentiation + +[Term] +id: GO:0061267 +name: mesonephric interstitial fibroblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +synonym: "mesonephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072141 ! renal interstitial fibroblast development +relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation + +[Term] +id: GO:0061268 +name: mesonephric interstitial fibroblast fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast." [GOC:mtg_kidney_jan10] +is_a: GO:0072153 ! renal interstitial fibroblast fate commitment +relationship: part_of GO:0061266 ! mesonephric interstitial fibroblast differentiation + +[Term] +id: GO:0061269 +name: mesonephric glomerular mesangial cell proliferation involved in mesonephros development +namespace: biological_process +def: "The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] +is_a: GO:0061209 ! cell proliferation involved in mesonephros development +is_a: GO:0072110 ! glomerular mesangial cell proliferation +relationship: part_of GO:0061247 ! mesonephric glomerular mesangium development + +[Term] +id: GO:0061270 +name: mesonephric intraglomerular mesangial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] +is_a: GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development +is_a: GO:0072123 ! intraglomerular mesangial cell proliferation + +[Term] +id: GO:0061271 +name: mesenchymal to epithelial transition involved in mesonephric renal vesicle formation +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] +is_a: GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis +is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation +relationship: part_of GO:0061262 ! mesonephric renal vesicle formation + +[Term] +id: GO:0061272 +name: mesonephric connecting tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "mesonephric collecting tubule development" EXACT [GOC:dph] +synonym: "mesonephric connecting duct development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0061242 ! mesonephric nephron tubule development +is_a: GO:0072027 ! connecting tubule development + +[Term] +id: GO:0061273 +name: mesonephric distal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis +is_a: GO:0072156 ! distal tubule morphogenesis +relationship: part_of GO:0061274 ! mesonephric distal tubule development + +[Term] +id: GO:0061274 +name: mesonephric distal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0061242 ! mesonephric nephron tubule development +is_a: GO:0072017 ! distal tubule development + +[Term] +id: GO:0061275 +name: mesonephric proximal tubule development +namespace: biological_process +def: "The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0061242 ! mesonephric nephron tubule development +is_a: GO:0072014 ! proximal tubule development + +[Term] +id: GO:0061276 +name: mesonephric proximal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0061240 ! mesonephric nephron tubule morphogenesis +is_a: GO:0072158 ! proximal tubule morphogenesis +relationship: part_of GO:0061275 ! mesonephric proximal tubule development + +[Term] +id: GO:0061277 +name: mesonephric nephron tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072172 ! mesonephric tubule formation +relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis + +[Term] +id: GO:0061278 +name: epithelial cell migration involved in mesonephric nephron tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis +relationship: part_of GO:0061240 ! mesonephric nephron tubule morphogenesis + +[Term] +id: GO:0061279 +name: epithelial cell migration involved in mesonephric distal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis +is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis +relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis + +[Term] +id: GO:0061280 +name: epithelial cell migration involved in mesonephric proximal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to mesonephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0061278 ! epithelial cell migration involved in mesonephric nephron tubule morphogenesis +is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis +relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis + +[Term] +id: GO:0061281 +name: specification of mesonephric connecting tubule identity +namespace: biological_process +def: "The process in which the connecting tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] +synonym: "specification of mesonephric collecting tubule identity" EXACT [GOC:dph] +is_a: GO:0061282 ! specification of mesonephric nephron tubule identity +is_a: GO:0072085 ! specification of connecting tubule identity +relationship: part_of GO:0061272 ! mesonephric connecting tubule development + +[Term] +id: GO:0061282 +name: specification of mesonephric nephron tubule identity +namespace: biological_process +def: "The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity." [GOC:mtg_kidney_jan10] +is_a: GO:0061227 ! pattern specification involved in mesonephros development +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0061226 ! proximal/distal pattern formation involved in mesonephric nephron development +relationship: part_of GO:0061277 ! mesonephric nephron tubule formation + +[Term] +id: GO:0061283 +name: specification of mesonephric distal tubule identity +namespace: biological_process +def: "The process in which the distal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] +is_a: GO:0061282 ! specification of mesonephric nephron tubule identity +is_a: GO:0072084 ! specification of distal tubule identity +relationship: part_of GO:0061273 ! mesonephric distal tubule morphogenesis + +[Term] +id: GO:0061284 +name: specification of mesonephric proximal tubule identity +namespace: biological_process +def: "The process in which the proximal tubule of the mesonephric nephron acquires its identity." [GOC:mtg_kidney_jan10] +is_a: GO:0061282 ! specification of mesonephric nephron tubule identity +is_a: GO:0072082 ! specification of proximal tubule identity +relationship: part_of GO:0061276 ! mesonephric proximal tubule morphogenesis + +[Term] +id: GO:0061285 +name: mesonephric capsule development +namespace: biological_process +def: "The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue." [GOC:mtg_kidney_jan10] +is_a: GO:0072127 ! renal capsule development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0061286 +name: mesonephric capsule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] +is_a: GO:0072128 ! renal capsule morphogenesis +relationship: part_of GO:0061285 ! mesonephric capsule development + +[Term] +id: GO:0061287 +name: mesonephric capsule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] +is_a: GO:0072129 ! renal capsule formation +relationship: part_of GO:0061286 ! mesonephric capsule morphogenesis + +[Term] +id: GO:0061288 +name: mesonephric capsule specification +namespace: biological_process +def: "The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] +is_a: GO:0061227 ! pattern specification involved in mesonephros development +is_a: GO:0072130 ! renal capsule specification +relationship: part_of GO:0061287 ! mesonephric capsule formation + +[Term] +id: GO:0061289 +name: Wnt signaling pathway involved in kidney development +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time." [GOC:mtg_kidney_jan10] +synonym: "Wnt receptor signaling pathway involved in kidney development" EXACT [] +synonym: "Wnt receptor signalling pathway involved in kidney development" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in kidney development" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +is_a: GO:0060995 ! cell-cell signaling involved in kidney development + +[Term] +id: GO:0061290 +name: canonical Wnt signaling pathway involved in metanephric kidney development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] +synonym: "canonical Wnt receptor signaling pathway involved in metanephric kidney development" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in metanephric kidney development" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in metanephric kidney development" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development +is_a: GO:0072204 ! cell-cell signaling involved in metanephros development + +[Term] +id: GO:0061291 +name: canonical Wnt signaling pathway involved in ureteric bud branching +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] +synonym: "canonical Wnt receptor signaling pathway involved in ureteric bud branching" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in ureteric bud branching" EXACT [GOC:mah] +is_a: GO:0061290 ! canonical Wnt signaling pathway involved in metanephric kidney development +is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development +relationship: part_of GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0061292 +name: canonical Wnt signaling pathway involved in mesonephros development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the mesonephros over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] +synonym: "canonical Wnt receptor signaling pathway involved in mesonephros development" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in mesonephros development" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in mesonephros development" EXACT [GOC:signaling] +is_a: GO:0060070 ! canonical Wnt signaling pathway +is_a: GO:0061210 ! cell-cell signaling involved in mesonephros development +is_a: GO:0061289 ! Wnt signaling pathway involved in kidney development + +[Term] +id: GO:0061293 +name: canonical Wnt signaling pathway involved in mesonephric nephron development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the mesonephric nephron over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_kidney_jan10] +synonym: "canonical Wnt receptor signaling pathway involved in mesonephric nephron development" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in mesonephric nephron development" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in mesonephric nephron development" EXACT [GOC:signaling] +is_a: GO:0061292 ! canonical Wnt signaling pathway involved in mesonephros development +relationship: part_of GO:0061215 ! mesonephric nephron development + +[Term] +id: GO:0061294 +name: mesonephric renal vesicle induction +namespace: biological_process +def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle." [GOC:mtg_kidney_jan10] +is_a: GO:0061217 ! regulation of mesonephros development +is_a: GO:0072034 ! renal vesicle induction +relationship: positively_regulates GO:0061262 ! mesonephric renal vesicle formation + +[Term] +id: GO:0061295 +name: regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] +synonym: "regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] +is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +relationship: regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis +relationship: regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis + +[Term] +id: GO:0061296 +name: negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] +synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] +is_a: GO:0061218 ! negative regulation of mesonephros development +is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +relationship: negatively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis +relationship: negatively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis + +[Term] +id: GO:0061297 +name: positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis" NARROW [] +synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis" EXACT [] +is_a: GO:0061213 ! positive regulation of mesonephros development +is_a: GO:0061295 ! regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +relationship: positively_regulates GO:0061235 ! mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis +relationship: positively_regulates GO:1901146 ! mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis + +[Term] +id: GO:0061298 +name: retina vasculature development in camera-type eye +namespace: biological_process +def: "The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] +synonym: "retinal vasculature development" EXACT [GOC:dph] +is_a: GO:0001944 ! vasculature development +relationship: part_of GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:0061299 +name: retina vasculature morphogenesis in camera-type eye +namespace: biological_process +def: "The process in which the vasculature of the retina is generated and organized." [GOC:BHF, GOC:dph] +synonym: "retinal vasculature morphogenesis" EXACT [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0061298 ! retina vasculature development in camera-type eye + +[Term] +id: GO:0061300 +name: cerebellum vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0001944 ! vasculature development + +[Term] +id: GO:0061301 +name: cerebellum vasculature morphogenesis +namespace: biological_process +def: "The process in which the vasculature of the cerebellum is generated and organized." [GOC:BHF, GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0021549 ! cerebellum development +relationship: part_of GO:0061300 ! cerebellum vasculature development + +[Term] +id: GO:0061302 +name: smooth muscle cell-matrix adhesion +namespace: biological_process +def: "The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules." [GOC:BHF, GOC:dph, PMID:8837777] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0061303 +name: cornea development in camera-type eye +namespace: biological_process +def: "The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye." [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0061304 +name: retinal blood vessel morphogenesis +namespace: biological_process +def: "The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure." [GOC:BHF, GOC:dph] +is_a: GO:0048514 ! blood vessel morphogenesis +is_a: GO:0061299 ! retina vasculature morphogenesis in camera-type eye + +[Term] +id: GO:0061305 +name: maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell." [GOC:dph, GOC:vw] +is_a: GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:0061306 +name: obsolete DNA strand renaturation involved in double-strand break repair +namespace: biological_process +def: "OBSOLETE. The identification and annealing of complementary base pairs in single-strand DNA that contributes to double-strand break repair." [GOC:dph] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0006302 +consider: GO:0036310 + +[Term] +id: GO:0061307 +name: cardiac neural crest cell differentiation involved in heart development +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches." [GOC:dph, GOC:mtg_heart, PMID:19705442] +is_a: GO:0014033 ! neural crest cell differentiation +is_a: GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:0061308 +name: cardiac neural crest cell development involved in heart development +namespace: biological_process +def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." [GOC:dph, GOC:mtg_heart] +is_a: GO:0014032 ! neural crest cell development +relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development + +[Term] +id: GO:0061309 +name: cardiac neural crest cell development involved in outflow tract morphogenesis +namespace: biological_process +def: "The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] +is_a: GO:0061308 ! cardiac neural crest cell development involved in heart development +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0061310 +name: canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in cardiac neural crest cell differentiation." [GOC:dph, GOC:mtg_heart] +synonym: "canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in cardiac neural crest cell differentiation involved in heart development" EXACT [GOC:signaling] +is_a: GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +relationship: part_of GO:0061307 ! cardiac neural crest cell differentiation involved in heart development + +[Term] +id: GO:0061311 +name: cell surface receptor signaling pathway involved in heart development +namespace: biological_process +def: "Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, GOC:signaling] +synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] +synonym: "cell surface receptor linked signalling pathway involved in heart development" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0061312 +name: BMP signaling pathway involved in heart development +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time." [GOC:dph, GOC:mtg_heart] +synonym: "BMP signalling pathway involved in heart development" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development + +[Term] +id: GO:0061313 +name: fibroblast growth factor receptor signaling pathway involved in heart development +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands and contributing to the progression of the heart over time." [GOC:mtg_heart] +synonym: "fibroblast growth factor receptor signalling pathway involved in heart development" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development + +[Term] +id: GO:0061314 +name: Notch signaling involved in heart development +namespace: biological_process +def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time." [GOC:mtg_heart] +synonym: "Notch signalling involved in heart development" EXACT [GOC:mah] +is_a: GO:0007219 ! Notch signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development + +[Term] +id: GO:0061315 +name: canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation +namespace: biological_process +def: "The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells." [GOC:mtg_heart] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation" EXACT [GOC:signaling] +is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +relationship: part_of GO:0060045 ! positive regulation of cardiac muscle cell proliferation + +[Term] +id: GO:0061316 +name: canonical Wnt signaling pathway involved in heart development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart] +synonym: "canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] +is_a: GO:0003306 ! Wnt signaling pathway involved in heart development +is_a: GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:0061317 +name: canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes." [GOC:mtg_heart, PMID:17576928] +synonym: "canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] +synonym: "canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment + +[Term] +id: GO:0061318 +name: renal filtration cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0061319 +name: nephrocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002520, GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0061318 ! renal filtration cell differentiation + +[Term] +id: GO:0061320 +name: pericardial nephrocyte differentiation +namespace: biological_process +alt_id: GO:0007513 +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000474, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] +synonym: "pericardial cell differentiation" NARROW [] +is_a: GO:0061319 ! nephrocyte differentiation + +[Term] +id: GO:0061321 +name: garland nephrocyte differentiation +namespace: biological_process +alt_id: GO:0007514 +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0000486, GOC:dph, GOC:mtg_kidney_jan10, GOC:sart, PMID:19783135] +synonym: "garland cell differentiation" EXACT [] +is_a: GO:0061319 ! nephrocyte differentiation +relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm + +[Term] +id: GO:0061322 +name: disseminated nephrocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [CL:0002524, GOC:19783135, GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0061319 ! nephrocyte differentiation + +[Term] +id: GO:0061323 +name: cell proliferation involved in heart morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0061324 +name: canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation +namespace: biological_process +def: "The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells." [GOC:dph, GOC:mtg_heart] +synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [] +synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:mah] +synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation" EXACT [GOC:signaling] +is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation +is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development +is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis + +[Term] +id: GO:0061325 +name: cell proliferation involved in outflow tract morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart] +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0061326 +name: renal tubule development +namespace: biological_process +def: "The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0061327 +name: anterior Malpighian tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0061328 +name: posterior Malpighian tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0061329 +name: Malpighian tubule principal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0061330 +name: Malpighian tubule stellate cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0061331 +name: epithelial cell proliferation involved in Malpighian tubule morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population and contributing to the shaping of a Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0061332 +name: Malpighian tubule bud morphogenesis +namespace: biological_process +def: "The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +synonym: "Malpighian tubule formation" EXACT [GOC:dph] +is_a: GO:0060572 ! morphogenesis of an epithelial bud +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0061333 +name: renal tubule morphogenesis +namespace: biological_process +def: "The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0061326 ! renal tubule development + +[Term] +id: GO:0061334 +name: cell rearrangement involved in Malpighian tubule morphogenesis +namespace: biological_process +def: "The movement of an epithelial cell with respect to other epithelial cells that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10] +synonym: "cell migration involved in Malpighian tubule morphogenesis" EXACT [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0061335 +name: cell growth involved in Malpighian tubule morphogenesis +namespace: biological_process +def: "The growth of an epithelial cell dependent on cycles of endoreplication, where growth contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0048588 ! developmental cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0061336 +name: cell morphogenesis involved in Malpighian tubule morphogenesis +namespace: biological_process +def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis + +[Term] +id: GO:0061337 +name: cardiac conduction +namespace: biological_process +def: "Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles." [GOC:dph] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0035637 ! multicellular organismal signaling + +[Term] +id: GO:0061338 +name: obsolete atrioventricular node impulse conduction delay +namespace: biological_process +def: "OBSOLETE. A heart process that modulates the propagation of the signal that causes the heart muscle to contract." [GOC:dph] +comment: This term was made obsolete because it was created before the cardiac conduction overhaul, and represents a measurement rather than a process. +synonym: "atrioventricular node impulse conduction delay" EXACT [] +is_obsolete: true +consider: GO:0086016 + +[Term] +id: GO:0061339 +name: establishment or maintenance of monopolar cell polarity +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis." [GOC:dph, GOC:vw] +is_a: GO:0007163 ! establishment or maintenance of cell polarity + +[Term] +id: GO:0061340 +name: establishment or maintenance of monopolar cell polarity regulating cell shape +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:dph, GOC:vw] +is_a: GO:0061339 ! establishment or maintenance of monopolar cell polarity +is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:0061341 +name: non-canonical Wnt signaling pathway involved in heart development +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time." [GOC:dph, GOC:mtg_heart, PMID:16860783] +synonym: "non-canonical Wnt receptor signaling pathway involved in heart development" EXACT [] +synonym: "non-canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] +synonym: "non-canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] +is_a: GO:0003306 ! Wnt signaling pathway involved in heart development +is_a: GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:0061342 +name: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart." [PMID:16860783] +synonym: "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway" EXACT [GOC:mah] +is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development +is_a: GO:0061344 ! regulation of cell adhesion involved in heart morphogenesis + +[Term] +id: GO:0061343 +name: cell adhesion involved in heart morphogenesis +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] +is_a: GO:0007155 ! cell adhesion +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0061344 +name: regulation of cell adhesion involved in heart morphogenesis +namespace: biological_process +def: "Any process that modulates the extent of cell adhesion contributing to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0061343 ! cell adhesion involved in heart morphogenesis + +[Term] +id: GO:0061345 +name: planar cell polarity pathway involved in cardiac muscle cell fate commitment +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate." [GOC:dph, GOC:mtg_heart, PMID:16860783] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development + +[Term] +id: GO:0061346 +name: planar cell polarity pathway involved in heart morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart." [GOC:dph, GOC:mtg_heart, PMID:16860783] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +is_a: GO:0061341 ! non-canonical Wnt signaling pathway involved in heart development +relationship: part_of GO:0003007 ! heart morphogenesis + +[Term] +id: GO:0061347 +name: planar cell polarity pathway involved in outflow tract morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract." [GOC:dph, GOC:mtg_heart, PMID:19056682] +is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0061348 +name: planar cell polarity pathway involved in ventricular septum morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum." [GOC:dph, GOC:mtg_heart, PMID:19056682] +is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis +relationship: part_of GO:0060412 ! ventricular septum morphogenesis + +[Term] +id: GO:0061349 +name: planar cell polarity pathway involved in cardiac right atrium morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium." [GOC:dph, GOC:mtg_heart, PMID:19056682] +is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis +relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis + +[Term] +id: GO:0061350 +name: planar cell polarity pathway involved in cardiac muscle tissue morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue." [GOC:dph, GOC:mtg_heart, PMID:19056682] +is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis +relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis + +[Term] +id: GO:0061351 +name: neural precursor cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell." [GOC:dph, GOC:yaf] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0061352 +name: cell chemotaxis involved in Malpighian tubule morphogenesis +namespace: biological_process +def: "The directed movement of the outgrowing Malpighian tubule guided by specific chemical cues/signals. Movement may be towards a guidance cue (positive chemotaxis) or away from it (negative chemotaxis). Guidance contributes to the final positioning of the tubule." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0060326 ! cell chemotaxis +is_a: GO:0061334 ! cell rearrangement involved in Malpighian tubule morphogenesis + +[Term] +id: GO:0061353 +name: BMP signaling pathway involved in Malpighian tubule cell chemotaxis +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] +synonym: "bone morphogenic protein receptor signalling pathway involved in Malpighian tubule cell chemotaxis" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0061352 ! cell chemotaxis involved in Malpighian tubule morphogenesis + +[Term] +id: GO:0061354 +name: planar cell polarity pathway involved in pericardium morphogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium." [GOC:dph, GOC:mtg_heart, PMID:19056682] +is_a: GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis +relationship: part_of GO:0003344 ! pericardium morphogenesis + +[Term] +id: GO:0061355 +name: Wnt protein secretion +namespace: biological_process +def: "The controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] +is_a: GO:0009306 ! protein secretion +is_a: GO:0023061 ! signal release +relationship: part_of GO:0198738 ! cell-cell signaling by wnt + +[Term] +id: GO:0061356 +name: regulation of Wnt protein secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0061355 ! Wnt protein secretion + +[Term] +id: GO:0061357 +name: positive regulation of Wnt protein secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0061356 ! regulation of Wnt protein secretion +relationship: positively_regulates GO:0061355 ! Wnt protein secretion + +[Term] +id: GO:0061358 +name: negative regulation of Wnt protein secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell." [GOC:bf, PMID:19223472] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0061356 ! regulation of Wnt protein secretion +relationship: negatively_regulates GO:0061355 ! Wnt protein secretion + +[Term] +id: GO:0061359 +name: regulation of Wnt signaling pathway by Wnt protein secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell." [GOC:bf, GOC:jl, PMID:19223472] +synonym: "regulation of Wnt receptor signaling pathway by Wnt protein secretion" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway by Wnt protein secretion" EXACT [GOC:mah] +synonym: "regulation of Wnt-activated signaling pathway by Wnt protein secretion" EXACT [GOC:signaling] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +is_a: GO:0061355 ! Wnt protein secretion + +[Term] +id: GO:0061360 +name: optic chiasma development +namespace: biological_process +def: "The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature." [GOC:dph] +synonym: "optic chiasm development" EXACT [GOC:dph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021554 ! optic nerve development + +[Term] +id: GO:0061361 +name: positive regulation of maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] +is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape +is_a: GO:2000247 ! positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +relationship: positively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:0061362 +name: negative regulation of maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape." [GOC:dph] +is_a: GO:2000115 ! regulation of maintenance of bipolar cell polarity regulating cell shape +is_a: GO:2000750 ! negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +relationship: negatively_regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:0061363 +name: negative regulation of progesterone biosynthesis involved in luteolysis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis." [GOC:dph] +synonym: "functional luteolysis" EXACT [GOC:dph] +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:2000183 ! negative regulation of progesterone biosynthetic process +relationship: part_of GO:0001554 ! luteolysis + +[Term] +id: GO:0061364 +name: apoptotic process involved in luteolysis +namespace: biological_process +def: "The apoptotic process that contributes to luteolysis." [GOC:mtg_apoptosis, PMID:18566128] +synonym: "apoptosis involved in luteolysis" NARROW [] +synonym: "structural luteolysis" EXACT [GOC:dph] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022602 ! ovulation cycle process +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0001554 ! luteolysis + +[Term] +id: GO:0061365 +name: positive regulation of triglyceride lipase activity +namespace: biological_process +def: "Any process that increases the activity of triglyceride lipase." [GOC:dph] +synonym: "positive regulation of TAG activity" EXACT [PMID:16054079] +is_a: GO:0060193 ! positive regulation of lipase activity + +[Term] +id: GO:0061366 +name: behavioral response to chemical pain +namespace: biological_process +def: "Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus." [GOC:dph] +is_a: GO:0007635 ! chemosensory behavior +is_a: GO:0048266 ! behavioral response to pain + +[Term] +id: GO:0061367 +name: behavioral response to acetic acid induced pain +namespace: biological_process +def: "Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus." [GOC:dph] +is_a: GO:0061366 ! behavioral response to chemical pain + +[Term] +id: GO:0061368 +name: behavioral response to formalin induced pain +namespace: biological_process +def: "Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus." [GOC:dph] +is_a: GO:0061366 ! behavioral response to chemical pain + +[Term] +id: GO:0061369 +name: negative regulation of testicular blood vessel morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle." [GOC:BHF, GOC:dph] +synonym: "negative regulation of testicular vasculature morphogenesis" BROAD [GOC:BHF, GOC:dph] +is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis + +[Term] +id: GO:0061370 +name: testosterone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of testosterone, an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4 C-5." [GOC:dph, GOC:yaf] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0061371 +name: determination of heart left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of the heart with respect to the left and right halves of the organism." [GOC:dph, GOC:mtg_heart] +synonym: "determination of cardiac left/right asymmetry" EXACT [GOC:dph] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:0061372 +name: activin receptor signaling pathway involved in heart jogging +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging." [GOC:dph, GOC:mtg_heart, GOC:signaling] +synonym: "activin receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] +is_a: GO:0032924 ! activin receptor signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development +relationship: part_of GO:0003146 ! heart jogging + +[Term] +id: GO:0061373 +name: mammillary axonal complex development +namespace: biological_process +def: "The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain." [GOC:dph, GOC:yaf, PMID:10662642] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021767 ! mammillary body development + +[Term] +id: GO:0061374 +name: mammillothalamic axonal tract development +namespace: biological_process +def: "The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit." [GOC:dph, GOC:yaf, PMID:10662642] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061373 ! mammillary axonal complex development + +[Term] +id: GO:0061375 +name: mammillotectal axonal tract development +namespace: biological_process +def: "The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus." [GOC:dph, GOC:yaf, PMID:10662642] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061373 ! mammillary axonal complex development + +[Term] +id: GO:0061376 +name: mammillotegmental axonal tract development +namespace: biological_process +def: "The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons." [GOC:dph, GOC:yaf, PMID:10662642] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061373 ! mammillary axonal complex development + +[Term] +id: GO:0061377 +name: mammary gland lobule development +namespace: biological_process +def: "The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030879 ! mammary gland development + +[Term] +id: GO:0061378 +name: corpora quadrigemina development +namespace: biological_process +def: "The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:0061379 +name: inferior colliculus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061378 ! corpora quadrigemina development + +[Term] +id: GO:0061380 +name: superior colliculus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain." [GOC:dph, GOC:yaf] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0061378 ! corpora quadrigemina development + +[Term] +id: GO:0061381 +name: cell migration in diencephalon +namespace: biological_process +def: "The orderly movement of a cell that will reside in the diencephalon." [GOC:dph] +is_a: GO:0021885 ! forebrain cell migration +relationship: part_of GO:0021536 ! diencephalon development + +[Term] +id: GO:0061382 +name: Malpighian tubule tip cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells." [GOC:dph, GOC:mtg_kidney_jan10, PMID:7821213] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0072002 ! Malpighian tubule development + +[Term] +id: GO:0061383 +name: trabecula morphogenesis +namespace: biological_process +def: "The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0061384 +name: heart trabecula morphogenesis +namespace: biological_process +def: "The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue." [GOC:dph] +is_a: GO:0061383 ! trabecula morphogenesis + +[Term] +id: GO:0061385 +name: fibroblast proliferation involved in heart morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart." [GOC:dph] +is_a: GO:0048144 ! fibroblast proliferation +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis + +[Term] +id: GO:0061386 +name: closure of optic fissure +namespace: biological_process +def: "The closure of the temporary ventral gap in the optic cup that contributes to its shaping." [GOC:dph] +synonym: "closure or choriod fissure" RELATED [GOC:dph] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet +relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development + +[Term] +id: GO:0061387 +name: regulation of extent of cell growth +namespace: biological_process +def: "Any process that modulates the extent of cell growth." [GOC:mah, GOC:vw] +is_a: GO:0001558 ! regulation of cell growth +relationship: part_of GO:0008361 ! regulation of cell size + +[Term] +id: GO:0061388 +name: regulation of rate of cell growth +namespace: biological_process +def: "Any process that modulates the rate of cell growth." [GOC:mah, GOC:vw] +is_a: GO:0001558 ! regulation of cell growth + +[Term] +id: GO:0061389 +name: regulation of direction of cell growth +namespace: biological_process +def: "Any process that modulates the direction of cell growth." [GOC:mah, GOC:vw] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0008360 ! regulation of cell shape + +[Term] +id: GO:0061390 +name: positive regulation of direction of cell growth +namespace: biological_process +def: "Any process that increases the direction of cell growth." [GOC:mah, GOC:vw] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0061389 ! regulation of direction of cell growth + +[Term] +id: GO:0061391 +name: negative regulation of direction of cell growth +namespace: biological_process +def: "Any process that decreases the direction of cell growth." [GOC:mah, GOC:vw] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0061389 ! regulation of direction of cell growth + +[Term] +id: GO:0061392 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to osmotic stress +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0071470 + +[Term] +id: GO:0061393 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, PMID:12086627, PMID:9858577] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045944 +consider: GO:0071470 + +[Term] +id: GO:0061394 +name: regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph] +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress +relationship: part_of GO:0071243 ! cellular response to arsenic-containing substance + +[Term] +id: GO:0061395 +name: positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0061394 ! regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus + +[Term] +id: GO:0061396 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0071280 + +[Term] +id: GO:0061397 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to copper ion +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045944 +consider: GO:0071280 + +[Term] +id: GO:0061398 +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to copper ion +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0000122 +consider: GO:0071280 + +[Term] +id: GO:0061399 +name: positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus." [GOC:dph] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0071279 ! cellular response to cobalt ion + +[Term] +id: GO:0061400 +name: positive regulation of transcription from RNA polymerase II promoter in response to calcium ion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus." [GOC:dph] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0071277 ! cellular response to calcium ion + +[Term] +id: GO:0061401 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045944 +consider: GO:0071476 + +[Term] +id: GO:0061402 +name: positive regulation of transcription from RNA polymerase II promoter in response to acidic pH +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7." [GOC:dph, GOC:go_curators] +synonym: "positive regulation of transcription from RNA polymerase II promoter in response to acidity" BROAD [] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0071468 ! cellular response to acidic pH + +[Term] +id: GO:0061403 +name: positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0071500 ! cellular response to nitrosative stress + +[Term] +id: GO:0061404 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to increased salt +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045944 +consider: GO:0071472 + +[Term] +id: GO:0061405 +name: positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0071464 ! cellular response to hydrostatic pressure + +[Term] +id: GO:0061406 +name: positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0042149 ! cellular response to glucose starvation + +[Term] +id: GO:0061407 +name: positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:dph] +is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress +relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide + +[Term] +id: GO:0061408 +name: positive regulation of transcription from RNA polymerase II promoter in response to heat stress +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph] +is_a: GO:0034605 ! cellular response to heat +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0061409 +name: positive regulation of transcription from RNA polymerase II promoter in response to freezing +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:dph] +is_a: GO:0061411 ! positive regulation of transcription from RNA polymerase II promoter in response to cold +is_a: GO:0071497 ! cellular response to freezing + +[Term] +id: GO:0061410 +name: positive regulation of transcription from RNA polymerase II promoter in response to ethanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus." [GOC:dph] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0071361 ! cellular response to ethanol + +[Term] +id: GO:0061411 +name: positive regulation of transcription from RNA polymerase II promoter in response to cold +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0070417 ! cellular response to cold + +[Term] +id: GO:0061412 +name: positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids." [GOC:dph] +is_a: GO:0034198 ! cellular response to amino acid starvation +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0061413 +name: regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source +namespace: biological_process +def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] +is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter + +[Term] +id: GO:0061414 +name: positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source +namespace: biological_process +def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] +is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter +is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source + +[Term] +id: GO:0061415 +name: negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source +namespace: biological_process +def: "A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:dph, PMID:19686338] +is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter +is_a: GO:0061413 ! regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source + +[Term] +id: GO:0061416 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to salt stress +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:dph, PMID:18667581] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0071472 + +[Term] +id: GO:0061417 +name: negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:dph, PMID:9767597] +is_a: GO:0043619 ! regulation of transcription from RNA polymerase II promoter in response to oxidative stress +is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0061418 +name: regulation of transcription from RNA polymerase II promoter in response to hypoxia +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:12511571] +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress +relationship: part_of GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:0061419 +name: positive regulation of transcription from RNA polymerase II promoter in response to hypoxia +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus + +[Term] +id: GO:0061420 +name: regulation of transcription from RNA polymerase II promoter in response to biotin starvation +namespace: biological_process +def: "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin." [GOC:dph, PMID:16533810] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0061421 +name: positive regulation of transcription by oleic acid +namespace: biological_process +def: "Any process involving oleic acid that activates or increases the rate of transcription." [GOC:dph, PMID:20395639] +is_a: GO:0045991 ! carbon catabolite activation of transcription + +[Term] +id: GO:0061422 +name: positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0." [GOC:dph, PMID:11523797, PMID:15299026, PMID:21749328] +synonym: "positive regulation of transcription from RNA polymerase II promoter in response to alkalinity" BROAD [] +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress +is_a: GO:0071469 ! cellular response to alkaline pH + +[Term] +id: GO:0061423 +name: positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, PMID:11523797] +is_a: GO:0010765 ! positive regulation of sodium ion transport +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0061424 +name: obsolete positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization." [GOC:dph, PMID:7500953] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of peroxisome organisation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0061425 +name: positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process." [GOC:dph, PMID:10608811, PMID:7760841] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:1900066 ! positive regulation of ethanol catabolic process + +[Term] +id: GO:0061426 +name: positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport." [GOC:dph, PMID:10234785, PMID:10870099] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:1900072 ! positive regulation of sulfite transport + +[Term] +id: GO:0061427 +name: obsolete negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph, PMID:15302821] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0061428 +name: negative regulation of transcription from RNA polymerase II promoter in response to hypoxia +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus." [GOC:dph, PMID:17785431] +is_a: GO:0061418 ! regulation of transcription from RNA polymerase II promoter in response to hypoxia +is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0061429 +name: positive regulation of transcription from RNA polymerase II promoter by oleic acid +namespace: biological_process +def: "Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dph, PMID:20395639] +is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter +is_a: GO:0061421 ! positive regulation of transcription by oleic acid + +[Term] +id: GO:0061430 +name: bone trabecula morphogenesis +namespace: biological_process +def: "The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod." [GOC:BHF, GOC:dph, GOC:vk] +is_a: GO:0061383 ! trabecula morphogenesis + +[Term] +id: GO:0061431 +name: cellular response to methionine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GOC:dph, PMID:7891681] +is_a: GO:0031670 ! cellular response to nutrient +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1904640 ! response to methionine + +[Term] +id: GO:0061432 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to methionine +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus." [GOC:dph, PMID:7891681] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0061433 +name: cellular response to caloric restriction +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake." [GOC:dph, PMID:17914901] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0061771 ! response to caloric restriction + +[Term] +id: GO:0061434 +name: obsolete regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus." [GOC:dph, PMID:17914901] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0090398 + +[Term] +id: GO:0061435 +name: positive regulation of transcription from a mobile element promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter." [GOC:dph, PMID:12230120, PMID:9271107] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated + +[Term] +id: GO:0061436 +name: establishment of skin barrier +namespace: biological_process +def: "Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability." [GOC:dph] +synonym: "epithelial barrier development" RELATED [GOC:dph] +synonym: "establishment of epithelial barrier" BROAD [GOC:dph] +synonym: "skin barrier development" RELATED [GOC:dph] +is_a: GO:0033561 ! regulation of water loss via skin +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0061437 +name: renal system vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] +is_a: GO:0001944 ! vasculature development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0061438 +name: renal system vasculature morphogenesis +namespace: biological_process +def: "The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0061437 ! renal system vasculature development + +[Term] +id: GO:0061439 +name: kidney vasculature morphogenesis +namespace: biological_process +def: "The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph, GOC:mtg_kidney_jan10] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0061438 ! renal system vasculature morphogenesis +relationship: part_of GO:0061440 ! kidney vasculature development + +[Term] +id: GO:0061440 +name: kidney vasculature development +namespace: biological_process +def: "The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure." [GOC:dph, GOC:mtg_kidney_jan10, PMID:11891195] +is_a: GO:0061437 ! renal system vasculature development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0061441 +name: renal artery morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood." [GOC:mtg_kidney_jan10, PMID:11891195] +is_a: GO:0048844 ! artery morphogenesis +relationship: part_of GO:0061439 ! kidney vasculature morphogenesis + +[Term] +id: GO:0061442 +name: cardiac muscle cell fate determination +namespace: biological_process +def: "The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph] +is_a: GO:0007521 ! muscle cell fate determination +is_a: GO:0060913 ! cardiac cell fate determination +relationship: part_of GO:0060923 ! cardiac muscle cell fate commitment + +[Term] +id: GO:0061443 +name: endocardial cushion cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:dph] +is_a: GO:0035051 ! cardiocyte differentiation +relationship: part_of GO:0003197 ! endocardial cushion development + +[Term] +id: GO:0061444 +name: endocardial cushion cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state." [GOC:BHF, GOC:dph] +is_a: GO:0055006 ! cardiac cell development +relationship: part_of GO:0061443 ! endocardial cushion cell differentiation + +[Term] +id: GO:0061445 +name: endocardial cushion cell fate commitment +namespace: biological_process +def: "The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell." [GOC:BHF, GOC:dph] +is_a: GO:0060957 ! endocardial cell fate commitment +relationship: part_of GO:0061443 ! endocardial cushion cell differentiation + +[Term] +id: GO:0061446 +name: endocardial cushion cell fate determination +namespace: biological_process +def: "The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [GOC:BHF, GOC:dph] +is_a: GO:0060913 ! cardiac cell fate determination +relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment + +[Term] +id: GO:0061447 +name: endocardial cushion cell fate specification +namespace: biological_process +def: "The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:BHF, GOC:dph] +is_a: GO:0060912 ! cardiac cell fate specification +relationship: part_of GO:0061445 ! endocardial cushion cell fate commitment + +[Term] +id: GO:0061448 +name: connective tissue development +namespace: biological_process +def: "The progression of a connective tissue over time, from its formation to the mature structure." [GOC:BHF] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0061449 +name: olfactory bulb tufted cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021772 ! olfactory bulb development + +[Term] +id: GO:0061450 +name: trophoblast cell migration +namespace: biological_process +def: "Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst." [GOC:dph] +is_a: GO:0001667 ! ameboidal-type cell migration +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007566 ! embryo implantation + +[Term] +id: GO:0061451 +name: retrotrapezoid nucleus development +namespace: biological_process +def: "The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration." [GOC:dph] +is_a: GO:0048857 ! neural nucleus development +relationship: part_of GO:0021550 ! medulla oblongata development + +[Term] +id: GO:0061452 +name: retrotrapezoid nucleus neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus." [GOC:dph] +is_a: GO:0021953 ! central nervous system neuron differentiation +relationship: part_of GO:0061451 ! retrotrapezoid nucleus development + +[Term] +id: GO:0061453 +name: interstitial cell of Cajal differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." [GOC:dph] +synonym: "ICC differentiation" RELATED [GOC:dph] +is_a: GO:0060563 ! neuroepithelial cell differentiation +is_a: GO:0060575 ! intestinal epithelial cell differentiation + +[Term] +id: GO:0061454 +name: release of sequestered calcium ion into cytosol by Golgi +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb] +synonym: "Golgi calcium ion export" BROAD [] +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0061856 ! Golgi calcium ion transmembrane transport + +[Term] +id: GO:0061455 +name: integral component of muscle cell projection membrane +namespace: cellular_component +def: "The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:dph, GOC:tb] +synonym: "integral to muscle cell projection membrane" EXACT [] +is_a: GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0036195 ! muscle cell projection membrane + +[Term] +id: GO:0061456 +name: mesenchymal stem cell migration involved in uteric bud morphogenesis +namespace: biological_process +def: "The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:dph, GOC:tb] +is_a: GO:0035787 ! cell migration involved in kidney development +relationship: part_of GO:0060675 ! ureteric bud morphogenesis + +[Term] +id: GO:0061457 +name: mesonephric cell migration involved in male gonad development +namespace: biological_process +def: "The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development." [GOC:dph, GOC:tb] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0061458 +name: reproductive system development +namespace: biological_process +def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0061459 +name: L-arginine transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0005288 +alt_id: GO:0015181 +alt_id: GO:0015598 +alt_id: GO:0102022 +def: "Enables the transfer of L-arginine from one side of a membrane to the other." [GOC:dph, RHEA:32143] +synonym: "arginine permease activity" BROAD [] +synonym: "arginine porter activity" NARROW [] +synonym: "arginine transmembrane transporter activity" EXACT [] +synonym: "arginine-importing ATPase activity" NARROW [] +synonym: "ATP-dependent L-arginine transmembrane transporter activity" NARROW [] +synonym: "ATPase-coupled L-arginine transmembrane transporter activity" NARROW [] +synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] +synonym: "L-arginine transporter activity" EXACT [] +synonym: "L-arginine-importing ATPase activity" NARROW [] +xref: RHEA:32143 +is_a: GO:0008324 ! cation transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity +is_a: GO:0015179 ! L-amino acid transmembrane transporter activity + +[Term] +id: GO:0061462 +name: protein localization to lysosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a lysosome." [GOC:dph] +is_a: GO:0072665 ! protein localization to vacuole + +[Term] +id: GO:0061463 +name: O-acetyl-ADP-ribose deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate." [GOC:dph] +is_a: GO:0019213 ! deacetylase activity + +[Term] +id: GO:0061464 +name: obsolete plasma membrane part of cell-substrate junction +namespace: cellular_component +def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell-substrate junction." [GOC:dph] +comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. +is_obsolete: true + +[Term] +id: GO:0061465 +name: obsolete plasma membrane part of hemidesmosome +namespace: cellular_component +def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a hemidesmosome." [GOC:dph] +comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. +is_obsolete: true + +[Term] +id: GO:0061466 +name: obsolete plasma membrane part of cell junction +namespace: cellular_component +def: "OBSOLETE. The part of the plasma membrane that contributes to the structure of a cell junction." [GOC:dph] +comment: The reasons for obsoletion are that (1) this term does not have any gene products associated with them and (2) it can be represented as a GO-CAM. +is_obsolete: true + +[Term] +id: GO:0061468 +name: karyomere +namespace: cellular_component +def: "A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division." [GOC:dph, PMID:12734396, PMID:22863006] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0061469 +name: regulation of type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation." [GOC:dph] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0044342 ! type B pancreatic cell proliferation + +[Term] +id: GO:0061470 +name: T follicular helper cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell." [GOC:dph, PMID:21572431] +synonym: "T-helper follicular cell differentiation" EXACT [GOC:dph] +is_a: GO:0042093 ! T-helper cell differentiation + +[Term] +id: GO:0061471 +name: karyomere assembly +namespace: biological_process +def: "The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle." [GOC:dph, PMID:9732278] +is_a: GO:0070925 ! organelle assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly + +[Term] +id: GO:0061472 +name: karyomere membrane fusion +namespace: biological_process +def: "Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus." [GOC:dph, PMID:2734396] +is_a: GO:0090174 ! organelle membrane fusion +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007084 ! mitotic nuclear membrane reassembly + +[Term] +id: GO:0061473 +name: murein tripeptide carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate." [GOC:dph, PMID:22970852] +is_a: GO:0004181 ! metallocarboxypeptidase activity + +[Term] +id: GO:0061474 +name: phagolysosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a phagolysosome." [GOC:dph, PMID:22073313] +is_a: GO:0005765 ! lysosomal membrane +is_a: GO:0030670 ! phagocytic vesicle membrane +relationship: part_of GO:0032010 ! phagolysosome + +[Term] +id: GO:0061475 +name: cytosolic valyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:dph] +is_a: GO:0006438 ! valyl-tRNA aminoacylation + +[Term] +id: GO:0061476 +name: response to anticoagulant +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061477 +name: response to aromatase inhibitor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061478 +name: response to platelet aggregation inhibitor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061479 +name: response to reverse transcriptase inhibitor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus." [GOC:dph] +is_a: GO:0046677 ! response to antibiotic + +[Term] +id: GO:0061480 +name: response to asparaginase +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061481 +name: response to TNF agonist +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061482 +name: response to irinotecan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus." [GOC:dph] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0061483 +name: sulfinylpropanyl adenylate synthase +namespace: molecular_function +def: "Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate." [GOC:dph, PMID:8346915] +synonym: "SPA synthase" RELATED [PMID:8346915] +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0061484 +name: hematopoietic stem cell homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells." [GOC:dph, PMID:21508411] +is_a: GO:0048872 ! homeostasis of number of cells + +[Term] +id: GO:0061485 +name: memory T cell proliferation +namespace: biological_process +def: "The expansion of a memory T cell population by cell division." [GOC:dph, PMID:14647273] +is_a: GO:0042098 ! T cell proliferation + +[Term] +id: GO:0061486 +name: high-affinity fructose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:dph, PMID:10735857] +synonym: "high affinity fructose transmembrane transporter activity" EXACT [] +is_a: GO:0005353 ! fructose transmembrane transporter activity + +[Term] +id: GO:0061487 +name: obsolete DNA replication initiation from late origin +namespace: biological_process +def: "OBSOLETE. The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase." [GOC:dph, PMID:19221029] +comment: The reason for obsoletion is that there is no evidence that this is a different process from its parent term (DNA replication initiation, GO:0006270), but only that regulation of initiation at late origins differs from regulation of initiation at early origins. +synonym: "late replication origin firing" EXACT [GOC:dph, PMID:19221029] +is_obsolete: true +consider: GO:0101017 + +[Term] +id: GO:0061492 +name: asymmetric protein localization to old or new spindle pole body +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, PMID:22119525] +is_a: GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:0061493 +name: central plaque of mitotic spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body." [GOC:dph] +is_a: GO:0005823 ! central plaque of spindle pole body +relationship: part_of GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0061496 +name: half bridge of mitotic spindle pole body +namespace: cellular_component +def: "Structure adjacent to the plaques of the mitotic spindle pole body." [GOC:dph] +is_a: GO:0005825 ! half bridge of spindle pole body +relationship: part_of GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0061497 +name: inner plaque of mitotic spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus." [GOC:dph, GOC:vw] +is_a: GO:0005822 ! inner plaque of spindle pole body +relationship: part_of GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0061498 +name: intermediate layer of mitotic spindle pole body +namespace: cellular_component +def: "Structure between the central and outer plaques of the mitotic spindle pole body." [GOC:dph] +is_a: GO:0005821 ! intermediate layer of spindle pole body +relationship: part_of GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0061499 +name: outer plaque of mitotic spindle pole body +namespace: cellular_component +def: "One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm." [GOC:dph] +is_a: GO:0005824 ! outer plaque of spindle pole body +relationship: part_of GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0061501 +name: 2',3'-cyclic GMP-AMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP)." [GOC:dph, PMID:23258413, RHEA:42064] +synonym: "2',3' cyclic GMP-AMP synthase activity" EXACT [] +synonym: "2',3' cyclic-GMP-AMP synthase activity" EXACT [] +synonym: "cyclic 2',3' GAMP synthase activity" EXACT [] +synonym: "cyclic-GMP-AMP synthase activity" BROAD [] +xref: EC:2.7.7.86 +xref: Reactome:R-HSA-3244614 "cGAS produces cyclic GMP-AMP" +xref: RHEA:42064 +is_a: GO:0140699 ! cyclic GMP-AMP synthase activity + +[Term] +id: GO:0061502 +name: early endosome to recycling endosome transport +namespace: biological_process +def: "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes." [GOC:dph, GOC:kmv, PMID:21474295] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0098927 ! vesicle-mediated transport between endosomal compartments + +[Term] +id: GO:0061503 +name: tRNA threonylcarbamoyladenosine dehydratase +namespace: molecular_function +def: "Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A." [GOC:dph, PMID:23242255] +is_a: GO:0016836 ! hydro-lyase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0061504 +name: cyclic threonylcarbamoyladenosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [PMID:23242255] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0061506 +name: obsolete DNA topoisomerase type II (ATP-independent) activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:dph] +comment: This term was made obsolete because there is no evidence that this function exists. There are no known type II topoisomerase enzymes that are ATP-independent; as far as we know, ALL type II topoisomerase enzymes utilize hydrolysis of ATP. +is_obsolete: true + +[Term] +id: GO:0061507 +name: 2',3'-cyclic GMP-AMP binding +namespace: molecular_function +alt_id: GO:0098546 +def: "Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages." [GOC:dph, PMID:23258412, PMID:23910378] +synonym: "2',3' cGAMP binding" EXACT [] +synonym: "2',3' cyclic GAMP binding" EXACT [] +synonym: "2',3'-cGAMP binding" EXACT [] +synonym: "2',3'-cyclic GAMP binding" EXACT [] +synonym: "2',5-3',5'-cyclic GMP-AMP binding" EXACT [] +synonym: "c[G(2',5')pA(3',5')p] binding" EXACT [PMID:23910378] +synonym: "cyclic-GMP-AMP binding" BROAD [] +is_a: GO:0030551 ! cyclic nucleotide binding +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0061508 +name: CDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into CDP to produce a CTP." [PMID:7499258] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation + +[Term] +id: GO:0061509 +name: asymmetric protein localization to old mitotic spindle pole body +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw] +is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body +is_a: GO:1902440 ! protein localization to mitotic spindle pole body + +[Term] +id: GO:0061510 +name: asymmetric protein localization to new mitotic spindle pole body +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw] +is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body +is_a: GO:1902440 ! protein localization to mitotic spindle pole body + +[Term] +id: GO:0061511 +name: centriole elongation +namespace: biological_process +def: "The centrosome organization process by which a centriole increases in length as part of the process of replication." [GOC:dph, PMID:21576394] +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0007099 ! centriole replication + +[Term] +id: GO:0061512 +name: protein localization to cilium +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cilium." [GOC:dph] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0061513 +name: glucose 6-phosphate:inorganic phosphate antiporter activity +namespace: molecular_function +alt_id: GO:0008524 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out)." [GOC:dph, PMID:18337460] +synonym: "glucose 6-phosphate:phosphate antiporter activity" BROAD [] +xref: Reactome:R-HSA-198513 "Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4" +xref: Reactome:R-HSA-3229118 "Defective SLC37A4 does not exchange G6P and Pi across the ER membrane" +xref: Reactome:R-HSA-3257122 "SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane" +is_a: GO:0015526 ! hexose-phosphate:inorganic phosphate antiporter activity + +[Term] +id: GO:0061514 +name: interleukin-34-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-34 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:18467591] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0061515 +name: myeloid cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure." [GOC:dph] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0030099 ! myeloid cell differentiation + +[Term] +id: GO:0061516 +name: monocyte proliferation +namespace: biological_process +def: "The expansion of a monocyte population by cell division." [GOC:dph, PMID:18467591] +is_a: GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0061517 +name: macrophage proliferation +namespace: biological_process +def: "The expansion of a macrophage population by cell division." [GOC:dph, PMID:12614284, PMID:19466391] +is_a: GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0061518 +name: microglial cell proliferation +namespace: biological_process +def: "The expansion of a microglial cell population by cell division." [GOC:dph, PMID:17344397] +is_a: GO:0014009 ! glial cell proliferation +is_a: GO:0061517 ! macrophage proliferation + +[Term] +id: GO:0061519 +name: macrophage homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:dph, PMID:21727904] +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:0061520 +name: Langerhans cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a Langerhans cell." [GOC:dph, PMID:22729249] +is_a: GO:0043011 ! myeloid dendritic cell differentiation + +[Term] +id: GO:0061521 +name: hepatic stellate cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell." [GOC:dph, PMID:9407545] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0061522 +name: 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity +namespace: molecular_function +def: "Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA." [GOC:dph] +is_a: GO:0016289 ! CoA hydrolase activity + +[Term] +id: GO:0061523 +name: cilium disassembly +namespace: biological_process +def: "A cellular process that results in the breakdown of a cilium." [GOC:cilia, GOC:dph, PMID:17604723, PMID:27350441] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +synonym: "cilium resorption" EXACT [GOC:dph] +is_a: GO:0044782 ! cilium organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0061524 +name: central canal development +namespace: biological_process +def: "The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord." [GOC:cvs, GOC:dph, PMID:23409159] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021510 ! spinal cord development + +[Term] +id: GO:0061525 +name: hindgut development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut." [GOC:dph] +is_a: GO:0048565 ! digestive tract development + +[Term] +id: GO:0061526 +name: acetylcholine secretion +namespace: biological_process +def: "The regulated release of acetylcholine by a cell." [GOC:dph] +is_a: GO:0015870 ! acetylcholine transport +is_a: GO:0023061 ! signal release + +[Term] +id: GO:0061527 +name: dopamine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0099124 ! axonal dopamine secretion +relationship: part_of GO:0001963 ! synaptic transmission, dopaminergic + +[Term] +id: GO:0061528 +name: aspartate secretion +namespace: biological_process +def: "The regulated release of aspartate by a cell." [GOC:dph] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0061529 +name: epinephrine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter." [GOC:dph] +synonym: "adrenaline secretion, neurotransmission" EXACT [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0048242 ! epinephrine secretion + +[Term] +id: GO:0061530 +name: aspartate secretion, neurotransmission +namespace: biological_process +def: "The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0061528 ! aspartate secretion + +[Term] +id: GO:0061531 +name: primary amine secretion +namespace: biological_process +def: "The regulated release of a primary amine by a cell." [GOC:dph] +is_a: GO:0015837 ! amine transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0061532 +name: primary amine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0061545 ! tyramine secretion + +[Term] +id: GO:0061533 +name: norepinephrine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter." [GOC:dph] +synonym: "noradrenaline secretion, neurotransmission" EXACT [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0048243 ! norepinephrine secretion + +[Term] +id: GO:0061534 +name: gamma-aminobutyric acid secretion, neurotransmission +namespace: biological_process +def: "The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0014051 ! gamma-aminobutyric acid secretion +relationship: part_of GO:0051932 ! synaptic transmission, GABAergic + +[Term] +id: GO:0061535 +name: glutamate secretion, neurotransmission +namespace: biological_process +def: "The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0014047 ! glutamate secretion +relationship: part_of GO:0035249 ! synaptic transmission, glutamatergic + +[Term] +id: GO:0061536 +name: glycine secretion +namespace: biological_process +def: "The controlled release of glycine by a cell." [GOC:dph] +is_a: GO:0015816 ! glycine transport +is_a: GO:0032940 ! secretion by cell + +[Term] +id: GO:0061537 +name: glycine secretion, neurotransmission +namespace: biological_process +def: "The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0061536 ! glycine secretion +relationship: part_of GO:0060012 ! synaptic transmission, glycinergic + +[Term] +id: GO:0061538 +name: histamine secretion, neurotransmission +namespace: biological_process +def: "The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0001821 ! histamine secretion +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0061539 +name: octopamine secretion +namespace: biological_process +def: "The controlled release of octopamine by a cell." [GOC:dph] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0032940 ! secretion by cell +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0061540 +name: octopamine secretion, neurotransmission +namespace: biological_process +def: "The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:0061539 ! octopamine secretion + +[Term] +id: GO:0061541 +name: rhabdomere morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [GOC:dph, PMID:22113834] +is_a: GO:0048812 ! neuron projection morphogenesis +relationship: part_of GO:0008594 ! photoreceptor cell morphogenesis +relationship: part_of GO:0042052 ! rhabdomere development + +[Term] +id: GO:0061542 +name: 3-demethylubiquinol-n 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n." [EC:2.1.1.64, GOC:dph] +synonym: "2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase" NARROW [] +synonym: "5-demethylubiquinone-10 methyltransferase" NARROW [] +synonym: "5-demethylubiquinone-9 methyltransferase" NARROW [] +synonym: "OMHMB-methyltransferase" RELATED [] +synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase" RELATED [] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0061543 +name: 3-demethylubiquinol-6 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6." [GOC:dph] +is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity + +[Term] +id: GO:0061544 +name: peptide secretion, neurotransmission +namespace: biological_process +def: "The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter." [GOC:dph] +is_a: GO:0002790 ! peptide secretion +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0061545 +name: tyramine secretion +namespace: biological_process +def: "The regulated release of a tyramine by a cell." [GOC:dph] +is_a: GO:0006812 ! cation transport +is_a: GO:0015844 ! monoamine transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0061531 ! primary amine secretion + +[Term] +id: GO:0061546 +name: tyramine secretion, neurotransmission +namespace: biological_process +def: "The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter." [GOC:dph] +is_a: GO:0061532 ! primary amine secretion, neurotransmission + +[Term] +id: GO:0061547 +name: glycogen synthase activity, transferring glucose-1-phosphate +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate." [GOC:dph, PMID:21356517] +xref: Reactome:R-HSA-3780994 "GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2" +xref: Reactome:R-HSA-3781024 "GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1" +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups + +[Term] +id: GO:0061548 +name: ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure." [GOC:dph] +synonym: "ganglia development" RELATED [GOC:dph] +synonym: "gangliogenesis" NARROW [GOC:BHF, GOC:rl] +is_a: GO:0009888 ! tissue development +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0007399 ! nervous system development + +[Term] +id: GO:0061549 +name: sympathetic ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure." [GOC:BHF, GOC:rl] +synonym: "sympathetic ganglia development" RELATED [GOC:dph] +is_a: GO:0061548 ! ganglion development +relationship: part_of GO:0048485 ! sympathetic nervous system development + +[Term] +id: GO:0061550 +name: cranial ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure." [GOC:dph] +synonym: "cranial ganglia development" RELATED [GOC:dph] +is_a: GO:0061548 ! ganglion development +relationship: part_of GO:0021545 ! cranial nerve development + +[Term] +id: GO:0061551 +name: trigeminal ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure." [GOC:dph] +synonym: "trigeminal ganglia development" RELATED [GOC:dph] +is_a: GO:0061550 ! cranial ganglion development + +[Term] +id: GO:0061552 +name: ganglion morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of ganglion are generated and organized." [GOC:dph] +synonym: "ganglia morphogenesis" RELATED [GOC:dph] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0061548 ! ganglion development + +[Term] +id: GO:0061553 +name: ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state." [GOC:dph] +synonym: "ganglia maturation" RELATED [GOC:dph] +is_a: GO:0048799 ! animal organ maturation +relationship: part_of GO:0061548 ! ganglion development + +[Term] +id: GO:0061554 +name: ganglion formation +namespace: biological_process +def: "The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] +synonym: "ganglia formation" RELATED [GOC:dph] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0061552 ! ganglion morphogenesis + +[Term] +id: GO:0061555 +name: ganglion structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] +synonym: "ganglia structural organization" RELATED [GOC:dph] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0061552 ! ganglion morphogenesis + +[Term] +id: GO:0061556 +name: trigeminal ganglion morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of a trigeminal ganglion is generated and organized." [GOC:dph] +synonym: "trigeminal ganglia morphogenesis" RELATED [GOC:dph] +is_a: GO:0061559 ! cranial ganglion morphogenesis +relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis +relationship: part_of GO:0061551 ! trigeminal ganglion development + +[Term] +id: GO:0061557 +name: trigeminal ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state." [GOC:dph] +synonym: "trigeminal ganglia maturation" RELATED [GOC:dph] +is_a: GO:0061558 ! cranial ganglion maturation +relationship: part_of GO:0021635 ! trigeminal nerve maturation +relationship: part_of GO:0061551 ! trigeminal ganglion development + +[Term] +id: GO:0061558 +name: cranial ganglion maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state." [GOC:dph] +synonym: "cranial ganglia maturation" RELATED [GOC:dph] +is_a: GO:0061553 ! ganglion maturation +relationship: part_of GO:0021605 ! cranial nerve maturation +relationship: part_of GO:0061550 ! cranial ganglion development + +[Term] +id: GO:0061559 +name: cranial ganglion morphogenesis +namespace: biological_process +def: "The process in which the anatomical structure of a cranial ganglion is generated and organized." [GOC:dph] +synonym: "cranial ganglia morphogenesis" RELATED [GOC:dph] +is_a: GO:0061552 ! ganglion morphogenesis +relationship: part_of GO:0021602 ! cranial nerve morphogenesis +relationship: part_of GO:0061550 ! cranial ganglion development + +[Term] +id: GO:0061560 +name: cranial ganglion formation +namespace: biological_process +def: "The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] +synonym: "cranial ganglia formation" RELATED [GOC:dph] +is_a: GO:0061554 ! ganglion formation +relationship: part_of GO:0061559 ! cranial ganglion morphogenesis + +[Term] +id: GO:0061561 +name: trigeminal ganglion formation +namespace: biological_process +def: "The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dph] +synonym: "trigeminal ganglia formation" RELATED [GOC:dph] +is_a: GO:0061560 ! cranial ganglion formation +relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis + +[Term] +id: GO:0061562 +name: cranial ganglion structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] +synonym: "cranial ganglia structural organization" RELATED [GOC:dph] +is_a: GO:0061555 ! ganglion structural organization +relationship: part_of GO:0021604 ! cranial nerve structural organization +relationship: part_of GO:0061559 ! cranial ganglion morphogenesis + +[Term] +id: GO:0061563 +name: trigeminal ganglion structural organization +namespace: biological_process +def: "The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure." [GOC:dph] +synonym: "trigeminal ganglia organization" RELATED [GOC:dph] +is_a: GO:0061562 ! cranial ganglion structural organization +relationship: part_of GO:0021637 ! trigeminal nerve structural organization +relationship: part_of GO:0061556 ! trigeminal ganglion morphogenesis + +[Term] +id: GO:0061564 +name: axon development +namespace: biological_process +def: "The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation)." [GOC:dph, GOC:pg, GOC:pr] +is_a: GO:0031175 ! neuron projection development + +[Term] +id: GO:0061565 +name: dAMP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP." [GOC:dph, PMID:23416111] +is_a: GO:0046940 ! nucleoside monophosphate phosphorylation + +[Term] +id: GO:0061566 +name: CMP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP." [GOC:dph, PMID:23416111] +is_a: GO:0046940 ! nucleoside monophosphate phosphorylation + +[Term] +id: GO:0061567 +name: dCMP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP." [GOC:dph, PMID:23416111] +is_a: GO:0046940 ! nucleoside monophosphate phosphorylation + +[Term] +id: GO:0061568 +name: GDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP." [GOC:dph, PMID:23416111] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation + +[Term] +id: GO:0061569 +name: UDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP." [GOC:dph, PMID:23416111] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation + +[Term] +id: GO:0061570 +name: dCDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into dCDP to produce a dCTP." [GOC:dph, PMID:23416111] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation + +[Term] +id: GO:0061571 +name: TDP phosphorylation +namespace: biological_process +def: "The process of introducing a phosphate group into TDP to produce a TTP." [GOC:dph, PMID:23416111] +is_a: GO:0006165 ! nucleoside diphosphate phosphorylation + +[Term] +id: GO:0061572 +name: actin filament bundle organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] +synonym: "actin filament cable organization" RELATED [GOC:dph] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0061573 +name: actin filament bundle retrograde transport +namespace: biological_process +def: "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell." [GOC:dph] +synonym: "actin filament cable retrograde transport" RELATED [GOC:dph] +is_a: GO:0070650 ! actin filament bundle distribution + +[Term] +id: GO:0061574 +name: ASAP complex +namespace: cellular_component +def: "A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1." [GOC:dph, PMID:12665594, PMID:16314458, PMID:22388736] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0061575 +name: cyclin-dependent protein serine/threonine kinase activator activity +namespace: molecular_function +alt_id: GO:0016534 +alt_id: GO:0016535 +def: "Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:dph, PMID:2569363, PMID:3322810] +synonym: "cyclin-dependent protein kinase 5 activator activity" NARROW [] +is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity +is_a: GO:0043539 ! protein serine/threonine kinase activator activity + +[Term] +id: GO:0061576 +name: acyl-CoA ceramide synthase complex +namespace: cellular_component +def: "A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1." [GOC:dph, PMID:15692566] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0061577 +name: calcium ion transmembrane transport via high voltage-gated calcium channel +namespace: biological_process +def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel." [GOC:dph] +synonym: "generation of L-type calcium current" RELATED [] +is_a: GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:0061578 +name: Lys63-specific deubiquitinase activity +namespace: molecular_function +def: "Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:dph, GOC:pg, PMID:18313383] +xref: Reactome:R-HSA-5357845 "RIPK1 is deubiquitinated" +xref: Reactome:R-HSA-5690856 "TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1" +xref: Reactome:R-HSA-5691411 "BRCA1-A complex deubiquitinates K63polyUb-histone H2A" +xref: Reactome:R-HSA-5691431 "PSMD14 cleaves K63-linked ubiquitin" +xref: Reactome:R-HSA-5691439 "BRISC complex deubiquitinates NLRP3" +xref: Reactome:R-HSA-5696547 "STAMBPL1 is a deubiquitinase" +xref: Reactome:R-HSA-688136 "TNFAIP3 (A20) deubiquitinates RIP2" +xref: Reactome:R-HSA-741411 "CYLD deubiquitinates NEMO" +xref: Reactome:R-HSA-8869506 "TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6" +xref: Reactome:R-HSA-936381 "OTUD5 deubiquitinates TRAF3" +xref: Reactome:R-HSA-936390 "CYLD mediated deubiquitination of DDX58 (RIG-I)" +is_a: GO:0101005 ! deubiquitinase activity + +[Term] +id: GO:0061579 +name: N-acyl homoserine lactone synthase activity +namespace: molecular_function +def: "Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone." [GOC:dph] +synonym: "autoinducer-1 synthase" RELATED [GOC:dph] +xref: EC:2.3.1.184 +xref: RHEA:10096 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0061580 +name: colon epithelial cell migration +namespace: biological_process +def: "The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] +is_a: GO:0061582 ! intestinal epithelial cell migration + +[Term] +id: GO:0061581 +name: corneal epithelial cell migration +namespace: biological_process +def: "The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0061582 +name: intestinal epithelial cell migration +namespace: biological_process +def: "The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:dph] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0061583 +name: colon epithelial cell chemotaxis +namespace: biological_process +def: "The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph] +is_a: GO:0060326 ! cell chemotaxis +is_a: GO:0061580 ! colon epithelial cell migration + +[Term] +id: GO:0061584 +name: hypocretin secretion +namespace: biological_process +def: "The controlled release of hypocretin from a cell or a tissue." [GOC:dph] +synonym: "orexin secretion" EXACT [GOC:dph] +is_a: GO:0002790 ! peptide secretion + +[Term] +id: GO:0061585 +name: hypocretin secretion, neurotransmission +namespace: biological_process +def: "The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter." [GOC:dph] +synonym: "orexin secretion, neurotransmission" EXACT [GOC:dph] +is_a: GO:0061544 ! peptide secretion, neurotransmission +is_a: GO:0061584 ! hypocretin secretion + +[Term] +id: GO:0061586 +name: positive regulation of transcription by transcription factor localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated + +[Term] +id: GO:0061587 +name: transfer RNA gene-mediated silencing +namespace: biological_process +def: "The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes." [GOC:dph, PMID:23707796] +synonym: "tgm silencing" EXACT [PMID:23707796] +synonym: "transfer RNA gene-mediated chromatin silencing" EXACT [GOC:dph] +synonym: "transfer RNA gene-mediated gene silencing" EXACT [GOC:dph] +synonym: "tRNA gene-mediated chromatin silencing" EXACT [GOC:dph] +synonym: "tRNA gene-mediated gene silencing" EXACT [GOC:dph] +is_a: GO:0140458 ! pre-transcriptional gene silencing by RNA + +[Term] +id: GO:0061588 +name: calcium activated phospholipid scrambling +namespace: biological_process +def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] +is_a: GO:0017121 ! plasma membrane phospholipid scrambling + +[Term] +id: GO:0061589 +name: calcium activated phosphatidylserine scrambling +namespace: biological_process +def: "The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] +is_a: GO:0061588 ! calcium activated phospholipid scrambling + +[Term] +id: GO:0061590 +name: calcium activated phosphatidylcholine scrambling +namespace: biological_process +def: "The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] +is_a: GO:0061588 ! calcium activated phospholipid scrambling + +[Term] +id: GO:0061591 +name: calcium activated galactosylceramide scrambling +namespace: biological_process +def: "The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus." [GOC:krc, PMID:23532839] +is_a: GO:0061588 ! calcium activated phospholipid scrambling + +[Term] +id: GO:0061592 +name: phosphatidylserine exposure on osteoblast involved in bone mineralization +namespace: biological_process +def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization." [GOC:krc, PMID:22936354] +is_a: GO:0017121 ! plasma membrane phospholipid scrambling +relationship: part_of GO:0030282 ! bone mineralization + +[Term] +id: GO:0061593 +name: sulfoquinovose isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose." [GOC:dph, PMID:24463506] +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0061594 +name: 6-deoxy-6-sulfofructose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP." [PMID:24463506] +xref: EC:2.7.1.184 +xref: MetaCyc:RXN-15297 +xref: RHEA:40443 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0061595 +name: 6-deoxy-6-sulfofructose-1-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate." [PMID:24463506] +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0061596 +name: 3-sulfolactaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+." [EC:1.1.1.373, GOC:dph, PMID:24463506] +xref: EC:1.1.1.373 +xref: MetaCyc:RXN-15299 +xref: RHEA:40511 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0061597 +name: obsolete cyclic pyranopterin monophosphate synthase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction GTP = cyclic pyranopterin phosphate + diphosphate." [EC:4.1.99.18, GOC:dph, PMID:18154309] +comment: This term was made obsolete because it represents two distinct molecular functions. +is_obsolete: true + +[Term] +id: GO:0061598 +name: molybdopterin adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin." [EC:2.7.7.75, GOC:dph] +xref: EC:2.7.7.75 +xref: RHEA:31331 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0061599 +name: molybdopterin molybdotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP." [EC:2.10.1.1, GOC:dph] +xref: EC:2.10.1.1 +xref: Reactome:R-HSA-947531 "Molybdenum ion transfer onto molybdopterin" +xref: RHEA:35047 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0061602 +name: molybdenum cofactor cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor." [EC:2.7.7.76, GOC:dph] +xref: EC:2.7.7.76 +xref: RHEA:31335 +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0061603 +name: molybdenum cofactor guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor." [EC:2.7.7.77, GOC:dph] +xref: EC:2.7.7.77 +xref: RHEA:34243 +is_a: GO:0070568 ! guanylyltransferase activity + +[Term] +id: GO:0061604 +name: molybdopterin-synthase sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase." [EC:2.8.1.11, GOC:dph, PMID:18154309, PMID:22370186] +xref: EC:2.8.1.11 +xref: RHEA:48612 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0061605 +name: molybdopterin-synthase adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP." [EC:2.7.7.80, GOC:dph, PMID:18154309, PMID:22370186] +xref: EC:2.7.7.80 +xref: RHEA:43616 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0061606 +name: N-terminal protein amino acid propionylation +namespace: biological_process +def: "The propionylation of the N-terminal amino acid of proteins." [GOC:dph, PMID:17267393, PMID:23043182] +is_a: GO:0043687 ! post-translational protein modification + +[Term] +id: GO:0061607 +name: peptide alpha-N-propionyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein." [GOC:dph, PMID:23043182] +synonym: "N-terminal propionyltransferase activity" EXACT [PMID:23043182] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0061608 +name: nuclear import signal receptor activity +namespace: molecular_function +def: "Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein." [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport] +synonym: "importin activity" RELATED [] +is_a: GO:0140142 ! nucleocytoplasmic carrier activity + +[Term] +id: GO:0061609 +name: fructose-1-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde." [GOC:dph, GOC:glycolysis, ISBN:0201090910, RHEA:30851] +xref: Reactome:R-HSA-5656438 "Defective ALDOB does not cleave Fru 1-P to GA and DHAP" +xref: Reactome:R-HSA-70342 "ALDOB tetramer cleaves Fru-1-P to GA and DHAP" +xref: RHEA:30851 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0061610 +name: glycerol to glycerone phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate." [GOC:dph, ISBN:0201090910] +synonym: "glycerol metabolism to DHAP" EXACT [GOC:dph] +synonym: "glycerol metabolism to dihydroxyacetone phosphate" EXACT [GOC:dph] +synonym: "glycerol metabolism to glycerone phosphate" EXACT [GOC:dph] +synonym: "glycerol to DHAP metabolic process" EXACT [GOC:dph] +synonym: "glycerol to dihydroxyacetone phosphate metabolic process" EXACT [GOC:dph] +is_a: GO:0006071 ! glycerol metabolic process + +[Term] +id: GO:0061611 +name: mannose to fructose-6-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +synonym: "mannose metabolism to fructose-6-phosphate" EXACT [GOC:dph] +is_a: GO:0006013 ! mannose metabolic process + +[Term] +id: GO:0061612 +name: galactose to glucose-1-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +is_a: GO:0006012 ! galactose metabolic process + +[Term] +id: GO:0061613 +name: glycolytic process from glycerol +namespace: biological_process +def: "The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH." [GOC:dph, ISBN:0201090910] +is_a: GO:0006096 ! glycolytic process +is_a: GO:0019563 ! glycerol catabolic process + +[Term] +id: GO:0061614 +name: miRNA transcription +namespace: biological_process +def: "The cellular synthesis of microRNA (miRNA) transcripts. MicroRNA genes are synthesized as primary (pri) miRNA transcripts and subsequently processed to produce the ~22nt miRNAs that function in gene regulation." [GOC:dph, GOC:kmv, PMID:18778799] +synonym: "microRNA gene transcription" EXACT [] +synonym: "miRNA gene transcription" EXACT [] +synonym: "pri-miRNA transcription by RNA polymerase II" EXACT [] +synonym: "pri-miRNA transcription from RNA polymerase II promoter" EXACT [] +synonym: "primary miRNA gene transcription" EXACT [] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0061615 +name: glycolytic process through fructose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +synonym: "glycolysis through fructose-6-phosphate" EXACT [GOC:dph] +xref: MetaCyc:PWY-5484 +is_a: GO:0006096 ! glycolytic process + +[Term] +id: GO:0061616 +name: glycolytic process from fructose through fructose-6-phosphate +namespace: biological_process +def: "The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +synonym: "glycolysis from fructose through fructose-6-phosphate" EXACT [GOC:dph] +xref: MetaCyc:PWY-5484 +is_a: GO:0006001 ! fructose catabolic process +is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:0061617 +name: MICOS complex +namespace: cellular_component +def: "Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60." [GOC:dph, PMID:21944719, PMID:21987634, PMID:22009199, PMID:24687277] +synonym: "Fcj1 complex" EXACT [GOC:dph] +synonym: "MINOS complex" EXACT [GOC:dph] +synonym: "mitochondrial contact site and cristae organizing system" EXACT [GOC:dph] +synonym: "MitOS complex" EXACT [GOC:dph] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane + +[Term] +id: GO:0061618 +name: obsolete sublamina densa +namespace: cellular_component +def: "OBSOLETE. The part of the basement membrane that lies beneath the lamina densa, containing anchoring fibrils, anchoring plaques, collagen fibers, and elastic fibers." [GOC:BHF, PMID:15623520] +comment: This term was made obsolete because it is thought to be an experimental artefact. +is_obsolete: true + +[Term] +id: GO:0061619 +name: glycolytic process from mannose through fructose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +is_a: GO:0019309 ! mannose catabolic process +is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:0061620 +name: glycolytic process through glucose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +xref: MetaCyc:GLYCOLYSIS +is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:0061621 +name: canonical glycolysis +namespace: biological_process +def: "The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910, ISBN:0879010479] +xref: MetaCyc:ANAGLYCOLYSIS-PWY +xref: MetaCyc:PWY66-400 +xref: Reactome:R-HSA-70171 "Glycolysis, Homo sapiens" +xref: Wikipedia:Glycolysis +is_a: GO:0006735 ! NADH regeneration +is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate +is_a: GO:0061718 ! glucose catabolic process to pyruvate + +[Term] +id: GO:0061622 +name: glycolytic process through glucose-1-phosphate +namespace: biological_process +def: "The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910] +is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate + +[Term] +id: GO:0061623 +name: glycolytic process from galactose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP." [GOC:dph, ISBN:0201090910] +is_a: GO:0019388 ! galactose catabolic process +is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate + +[Term] +id: GO:0061624 +name: fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate." [GOC:dph, ISBN:0201090910] +is_a: GO:0006001 ! fructose catabolic process +is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process + +[Term] +id: GO:0061625 +name: glycolytic process through fructose-1-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH." [GOC:dph, ISBN:0201090910] +is_a: GO:0006001 ! fructose catabolic process +is_a: GO:0006096 ! glycolytic process + +[Term] +id: GO:0061626 +name: pharyngeal arch artery morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery." [GOC:BHF, GOC:dph, PMID:20122914] +synonym: "aortic arch artery morphogenesis" BROAD [GOC:dph] +is_a: GO:0048844 ! artery morphogenesis +relationship: part_of GO:0060037 ! pharyngeal system development + +[Term] +id: GO:0061627 +name: S-methylmethionine-homocysteine S-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+." [EC:2.1.1.10, GOC:BHF, GOC:dph] +synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10] +synonym: "methylmethionine:homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] +synonym: "S-methylmethionine homocysteine transmethylase activity" RELATED [EC:2.1.1.10] +xref: Reactome:R-HSA-5696838 "BHMT2 tetramer transfers CH3 group from SMM to LHCYS" +xref: RHEA:26337 +is_a: GO:0008172 ! S-methyltransferase activity + +[Term] +id: GO:0061628 +name: H3K27me3 modified histone binding +namespace: molecular_function +def: "Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation." [GOC:dph, PMID:23948251] +synonym: "H3-K27me3 modified histone binding" EXACT [GOC:dph] +is_a: GO:0035064 ! methylated histone binding + +[Term] +id: GO:0061629 +name: RNA polymerase II-specific DNA-binding transcription factor binding +namespace: molecular_function +alt_id: GO:0001085 +alt_id: GO:0001102 +alt_id: GO:0001103 +def: "Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription." [GOC:dph, GOC:vw] +synonym: "RNA polymerase II activating transcription factor binding" RELATED [] +synonym: "RNA polymerase II repressing transcription factor binding" RELATED [] +synonym: "RNA polymerase II sequence-specific DNA binding transcription factor binding" EXACT [] +synonym: "RNA polymerase II sequence-specific DNA-binding transcription factor binding" EXACT [] +synonym: "RNA polymerase II transcription factor binding" RELATED [] +is_a: GO:0140297 ! DNA-binding transcription factor binding + +[Term] +id: GO:0061630 +name: ubiquitin protein ligase activity +namespace: molecular_function +alt_id: GO:0090302 +alt_id: GO:0090622 +alt_id: GO:1904264 +alt_id: GO:1904822 +def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues." [GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777] +comment: This enzyme catalyzes a transferase reaction. +synonym: "APC-Cdc20 complex activity" NARROW [GOC:vw] +synonym: "APC-fizzy related complex activity" NARROW [GOC:vw] +synonym: "E3" RELATED [GOC:dph] +synonym: "E3 involved in endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] +synonym: "ER-associated E3 ligase" RELATED [PMID:24019521] +synonym: "protein ubiquitination activity" EXACT [GOC:dph] +synonym: "ubiquitin ligase activity" EXACT [GOC:dph] +synonym: "ubiquitin ligase activity involved in ER-associated degradation pathway" NARROW [GOC:TermGenie] +synonym: "ubiquitin protein ligase activity involved in chloroplast disassembly" NARROW [] +synonym: "ubiquitin protein ligase activity involved in ER-associated degradation pathway" NARROW [GOC:TermGenie] +synonym: "ubiquitin protein ligase activity involved in ERAD pathway" NARROW [] +synonym: "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition" NARROW [GOC:dph, GOC:mah, GOC:tb] +xref: Reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL" +xref: Reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1" +xref: Reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8" +xref: Reactome:R-HSA-3322429 "XIAP monoubiquinates TLE" +xref: Reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN" +xref: Reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1" +xref: Reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2" +xref: Reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1" +xref: Reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization" +xref: Reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation" +xref: Reactome:R-HSA-5246693 "APC is K63-polyubiquitinated" +xref: Reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1" +xref: Reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1" +xref: Reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3" +xref: Reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1" +xref: Reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1" +xref: Reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2" +xref: Reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3" +xref: Reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4" +xref: Reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1" +xref: Reactome:R-HSA-5674022 "BRAP autoubiquitinates" +xref: Reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX" +xref: Reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1" +xref: Reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal" +xref: Reactome:R-HSA-5689111 "PARK2 autoubiquitinates" +xref: Reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1" +xref: Reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II" +xref: Reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC" +xref: Reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI" +xref: Reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC" +xref: Reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2" +xref: Reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY" +xref: Reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53" +xref: Reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4" +xref: Reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53" +xref: Reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate" +xref: Reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination" +xref: Reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN" +xref: Reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin" +xref: Reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex" +xref: Reactome:R-HSA-8848829 "CBL autoubiquitinates" +xref: Reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN" +xref: Reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA" +xref: Reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7" +xref: Reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839" +xref: Reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR" +xref: Reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del" +xref: Reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5" +xref: Reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET" +xref: Reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination" +xref: Reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET" +xref: Reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex" +xref: Reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC" +xref: Reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA" +xref: Reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10" +xref: Reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2" +xref: Reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B" +xref: Reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA" +xref: Reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA" +xref: Reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11" +xref: Reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN" +xref: Reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN" +xref: Reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3" +xref: Reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3" +xref: Reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11" +xref: Reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5" +xref: Reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73" +xref: Reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2" +xref: Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2" +xref: Reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2" +xref: Reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2" +xref: Reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1" +xref: Reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3" +xref: Reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11" +xref: Reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL" +xref: Reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation" +xref: Reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216" +xref: Reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4" +xref: Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363" +xref: Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2" +xref: Reactome:R-HSA-9706354 "Ubiquitination of FLT3" +xref: Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3" +xref: Reactome:R-HSA-990526 "Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1" +is_a: GO:0004842 ! ubiquitin-protein transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061631 +name: ubiquitin conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [GOC:BioGRID, GOC:dph] +synonym: "E2" RELATED [GOC:dph] +synonym: "HECT E3" RELATED [GOC:dph] +xref: EC:2.3.2.23 +is_a: GO:0004842 ! ubiquitin-protein transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061632 +name: RNA lariat debranching enzyme activator activity +namespace: molecular_function +def: "Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [GOC:dph, PMID:24919400] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0061633 +name: transport-coupled glycolytic process through glucose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport." [GOC:dph] +is_a: GO:0061620 ! glycolytic process through glucose-6-phosphate +is_a: GO:0061718 ! glucose catabolic process to pyruvate + +[Term] +id: GO:0061634 +name: alpha-D-xyloside xylohydrolase +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose." [EC:3.2.1.177] +synonym: "alpha-xylosidase" RELATED [EC:3.2.1.177] +xref: EC:3.2.1.177 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0061635 +name: regulation of protein complex stability +namespace: biological_process +def: "Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly." [GOC:dph] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0061638 +name: CENP-A containing chromatin +namespace: cellular_component +alt_id: GO:1904834 +def: "The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment." [GOC:vw, PMID:20206496, PMID:22729156, PMID:24710126] +synonym: "centromeric core domain chromatin" RELATED [GOC:vw] +synonym: "centromeric core region chromatin" EXACT [GOC:vw] +synonym: "chromatin containing CENP-A" EXACT [] +synonym: "nuclear CENP-A containing chromatin" NARROW [] +is_a: GO:0000785 ! chromatin +relationship: part_of GO:0034506 ! chromosome, centromeric core domain + +[Term] +id: GO:0061639 +name: Cdv-dependent cytokinesis +namespace: biological_process +def: "A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells." [GOC:dph, PMID:18987308] +is_a: GO:0000910 ! cytokinesis + +[Term] +id: GO:0061640 +name: cytoskeleton-dependent cytokinesis +namespace: biological_process +def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph] +is_a: GO:0000910 ! cytokinesis + +[Term] +id: GO:0061641 +name: CENP-A containing chromatin organization +namespace: biological_process +def: "Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin." [GOC:dph] +synonym: "centromeric chromatin organization" RELATED [GOC:dph] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0061642 +name: chemoattraction of axon +namespace: biological_process +def: "The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:dph, GOC:krc] +is_a: GO:0050918 ! positive chemotaxis +relationship: part_of GO:0007411 ! axon guidance +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0061643 +name: chemorepulsion of axon +namespace: biological_process +def: "The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:dph, GOC:krc] +is_a: GO:0050919 ! negative chemotaxis +relationship: part_of GO:0007411 ! axon guidance +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0061644 +name: protein localization to CENP-A containing chromatin +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin." [GOC:dph, GOC:vw] +is_a: GO:0071168 ! protein localization to chromatin +is_a: GO:0071459 ! protein localization to chromosome, centromeric region + +[Term] +id: GO:0061645 +name: endocytic patch +namespace: cellular_component +def: "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0061646 +name: positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter." [GOC:pad, GOC:PARL] +is_a: GO:0051716 ! cellular response to stimulus +is_a: GO:1903296 ! positive regulation of glutamate secretion, neurotransmission + +[Term] +id: GO:0061647 +name: histone H3-K9 modification +namespace: biological_process +def: "The modification of histone H3 at a lysine in position 9 of the histone." [GOC:vw] +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0061648 +name: tooth replacement +namespace: biological_process +def: "The process whose specific outcome is the replacement of an existing tooth with another tooth." [GOC:dph, PMID:15170864] +is_a: GO:0042476 ! odontogenesis + +[Term] +id: GO:0061649 +name: ubiquitin modification-dependent histone binding +namespace: molecular_function +def: "Binding to a histone protein in which a residue has been modified by ubiquitination. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:dph, PMID:24526689] +synonym: "ubiquitinated histone binding" RELATED [] +is_a: GO:0042393 ! histone binding +is_a: GO:0140036 ! ubiquitin-dependent protein binding + +[Term] +id: GO:0061650 +name: ubiquitin-like protein conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [] +synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0061651 +name: Atg12 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0019777 ! Atg12 transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061652 +name: FAT10 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0019775 ! FAT10 transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061653 +name: ISG15 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0042296 ! ISG15 transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061654 +name: NEDD8 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0019788 ! NEDD8 transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061655 +name: Pup conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity +is_a: GO:0072496 ! Pup transferase activity + +[Term] +id: GO:0061656 +name: SUMO conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0019789 ! SUMO transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061657 +name: UFM1 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity +is_a: GO:0071568 ! UFM1 transferase activity + +[Term] +id: GO:0061658 +name: URM1 conjugating enzyme activity +namespace: molecular_function +def: "Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue." [GOC:dph] +synonym: "E2" RELATED [GOC:dph] +is_a: GO:0042294 ! URM1 transferase activity +is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity + +[Term] +id: GO:0061659 +name: ubiquitin-like protein ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0061660 +name: Atg12 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0019777 ! Atg12 transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061661 +name: FAT10 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0019775 ! FAT10 transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061662 +name: ISG15 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0042296 ! ISG15 transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061663 +name: NEDD8 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0019788 ! NEDD8 transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061664 +name: Pup ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0061659 ! ubiquitin-like protein ligase activity +is_a: GO:0072496 ! Pup transferase activity + +[Term] +id: GO:0061665 +name: SUMO ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0019789 ! SUMO transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061666 +name: UFM1 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0061659 ! ubiquitin-like protein ligase activity +is_a: GO:0071568 ! UFM1 transferase activity + +[Term] +id: GO:0061667 +name: URM1 ligase activity +namespace: molecular_function +def: "Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] +synonym: "E3" RELATED [GOC:dph] +is_a: GO:0042294 ! URM1 transferase activity +is_a: GO:0061659 ! ubiquitin-like protein ligase activity + +[Term] +id: GO:0061668 +name: mitochondrial ribosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits." [GOC:dph] +is_a: GO:0042255 ! ribosome assembly + +[Term] +id: GO:0061669 +name: spontaneous neurotransmitter secretion +namespace: biological_process +def: "Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193] +synonym: "stimulus-independent neurotransmitter secretion" EXACT [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion +relationship: part_of GO:0098814 ! spontaneous synaptic transmission + +[Term] +id: GO:0061670 +name: evoked neurotransmitter secretion +namespace: biological_process +def: "Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential." [GOC:dph, GOC:pad, GOC:PARL, PMID:21334193] +synonym: "stimulus-dependant neurotransmitter secretion" EXACT [GOC:dph] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0061671 +name: Cbp3p-Cbp6 complex +namespace: cellular_component +def: "A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly." [GOC:dph, GOC:rb, PMID:21670217] +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0061672 +name: glutathione hydrolase complex +namespace: cellular_component +def: "Enzyme complex that in S. cerevisiae has components Dug2/Dug3 and is able to catalyze the cleavage of glutathione into glutamate and Cys-Gly." [GOC:dph] +synonym: "gamma-glutamyltranspeptidase complex" EXACT [GOC:dph] +synonym: "glutamine amidotransferase II complex" NARROW [PMID:22277648] +synonym: "glutathionase complex" EXACT [GOC:dph] +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:0061673 +name: mitotic spindle astral microtubule +namespace: cellular_component +def: "Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [GOC:dph] +is_a: GO:0000235 ! astral microtubule +relationship: part_of GO:0072686 ! mitotic spindle + +[Term] +id: GO:0061674 +name: gap filling involved in double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining." [GOC:dph] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:0061675 +name: RBL family protein binding +namespace: molecular_function +def: "Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose." [PMID:22312473] +synonym: "rhamnose-binding lectin family protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0061676 +name: importin-alpha family protein binding +namespace: molecular_function +def: "Binding to a member of the importin-alpha family." [PMID:15350979, PMID:17170104, PMID:23734157] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0061677 +name: 2-dehydro-3-deoxy-D-gluconate aldolase activity +namespace: molecular_function +alt_id: GO:0043725 +def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate <=> pyruvate + D-glyceraldehyde." [EC:4.1.2.51, GOC:dph, PMID:12824170, RHEA:35583] +synonym: "2-keto-3-deoxygluconate aldolase activity" EXACT [] +synonym: "KDG aldolase activity" EXACT [] +xref: EC:4.1.2.51 +xref: MetaCyc:4.1.2.51-RXN +xref: MetaCyc:DHDOGALDOL-RXN +xref: RHEA:35583 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0061678 +name: Entner-Doudoroff pathway +namespace: biological_process +def: "A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate." [GOC:dph, PMID:12921536] +xref: MetaCyc:Entner-Doudoroff-Pathways +is_a: GO:0044275 ! cellular carbohydrate catabolic process + +[Term] +id: GO:0061679 +name: Entner-Doudoroff pathway through gluconate +namespace: biological_process +def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate." [GOC:dph, PMID:12921536] +synonym: "gluconate pathway" RELATED [] +is_a: GO:0061678 ! Entner-Doudoroff pathway + +[Term] +id: GO:0061680 +name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde +namespace: biological_process +def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde." [GOC:dph, MetaCyc:ENTNER-DOUDOROFF-PWY-II, PMID:12921536] +xref: MetaCyc:ENTNER-DOUDOROFF-PWY-II +is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate + +[Term] +id: GO:0061681 +name: Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate +namespace: biological_process +def: "The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate." [GOC:dph, MetaCyc:ENTNER-DOUFDOROFF-PWY-III, PMID:12921536] +xref: MetaCyc:ENTNER-DOUDOROFF-PWY-III +is_a: GO:0061679 ! Entner-Doudoroff pathway through gluconate + +[Term] +id: GO:0061682 +name: seminal vesicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a seminal vesicle are generated and organized." [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0061107 ! seminal vesicle development + +[Term] +id: GO:0061683 +name: branching involved in seminal vesicle morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem." [GOC:dph, PMID:16916376] +synonym: "gonecyst branching morphogenesis" EXACT [GOC:dph] +synonym: "seminal gland branching morphogenesis" EXACT [GOC:dph] +synonym: "seminal vesicle branching" EXACT [GOC:dph] +synonym: "seminal vesicle branching morphogenesis" EXACT [GOC:dph] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0061138 ! morphogenesis of a branching epithelium +relationship: part_of GO:0061108 ! seminal vesicle epithelium development +relationship: part_of GO:0061682 ! seminal vesicle morphogenesis + +[Term] +id: GO:0061684 +name: chaperone-mediated autophagy +namespace: biological_process +def: "The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded." [GOC:pad, GOC:PARL, PMID:22743996, PMID:23434281] +synonym: "CASA" BROAD [PMID:23434281] +synonym: "chaperone-assisted selective autophagy" EXACT [PMID:23434281] +synonym: "CMA" BROAD [PMID:22743996] +xref: Wikipedia:Chaperone-mediated_autophagy +is_a: GO:0006914 ! autophagy +is_a: GO:0030163 ! protein catabolic process + +[Term] +id: GO:0061685 +name: diphthine methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: diphthine methyl ester + H2O <=> diphthine + H+ + methanol." [GOC:dph, PMID:24739148, RHEA:42656] +xref: EC:3.1.1.97 +xref: RHEA:42656 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0061686 +name: hercynylcysteine sulfoxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O." [GOC:dph, PMID:24828577, PMID:4276459, RHEA:42704] +synonym: "hercynylcysteine S-oxide synthase" EXACT [GOC:dph] +synonym: "hercynylcysteine sulfoxide synthase" EXACT [] +xref: EC:1.14.99.51 +xref: RHEA:42704 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0061687 +name: detoxification of inorganic compound +namespace: biological_process +def: "Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds." [GOC:vw] +is_a: GO:0098754 ! detoxification + +[Term] +id: GO:0061688 +name: glycolytic process via Entner-Doudoroff Pathway +namespace: biological_process +def: "A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes." [GOC:dph, PMID:9657988] +synonym: "gluconate pathway" RELATED [] +is_a: GO:0006096 ! glycolytic process + +[Term] +id: GO:0061689 +name: tricellular tight junction +namespace: cellular_component +def: "An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet." [GOC:dk, GOC:dph, PMID:22520461, PMID:25822906] +is_a: GO:0070160 ! tight junction + +[Term] +id: GO:0061690 +name: lipoamidase activity +namespace: molecular_function +def: "Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein." [GOC:dph, PMID:14086741] +synonym: "lipoyl-X-hydrolase" EXACT [PMID:14086741] +xref: MetaCyc:RXN-13031 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0061691 +name: detoxification of hydrogen peroxide +namespace: biological_process +def: "Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph] +is_a: GO:0042743 ! hydrogen peroxide metabolic process +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:0042542 ! response to hydrogen peroxide + +[Term] +id: GO:0061692 +name: cellular detoxification of hydrogen peroxide +namespace: biological_process +def: "Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dph, GOC:vw] +is_a: GO:0061691 ! detoxification of hydrogen peroxide +is_a: GO:0098869 ! cellular oxidant detoxification +relationship: part_of GO:0070301 ! cellular response to hydrogen peroxide + +[Term] +id: GO:0061693 +name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine." [EC:2.7.8.37, GOC:dph, PMID:22089136] +xref: EC:2.7.8.37 +xref: MetaCyc:RXN0-6732 +xref: RHEA:34679 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0061694 +name: alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex +namespace: cellular_component +def: "A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity." [GOC:dph, PMID:22089136] +comment: An example of this complex is PhnI (P16687) in Escherichia coli. +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:0061695 +name: transferase complex, transferring phosphorus-containing groups +namespace: cellular_component +def: "A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:bhm, GOC:dph] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0061696 +name: pituitary gonadotropin complex +namespace: cellular_component +def: "A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function." [GOC:dph, PMID:11420129] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0061697 +name: protein-glutaryllysine deglutarylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:dph, PMID:24703693] +comment: This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide. +xref: RHEA:47664 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0061698 +name: protein deglutarylation +namespace: biological_process +def: "The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein." [GOC:dph, PMID:24703693] +is_a: GO:0035601 ! protein deacylation + +[Term] +id: GO:0061699 +name: peptidyl-lysine deglutarylation +namespace: biological_process +def: "The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein." [GOC:dph, PMID:24703693] +is_a: GO:0061698 ! protein deglutarylation + +[Term] +id: GO:0061700 +name: GATOR2 complex +namespace: cellular_component +def: "A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins." [GOC:krc, GOC:rb, PMID:23723238, PMID:25934700] +comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. +synonym: "SEACAT complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0035859 ! Seh1-associated complex + +[Term] +id: GO:0061701 +name: bacterial outer membrane vesicle +namespace: cellular_component +def: "A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes." [GOC:dph, GOC:pr, PMID:20596524] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:0061702 +name: inflammasome complex +namespace: cellular_component +def: "A cytosolic protein complex that is capable of activating caspase-1." [GOC:dph, PMID:17599095] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0061703 +name: pyroptosome complex +namespace: cellular_component +def: "A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis." [GOC:dph, PMID:17599095] +synonym: "ASC pyroptosome" EXACT [PMID:17599095] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0061704 +name: glycolytic process from sucrose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, PMID:15012287] +is_a: GO:0005987 ! sucrose catabolic process +is_a: GO:0006096 ! glycolytic process + +[Term] +id: GO:0061705 +name: sucrose catabolic process to fructose-6-phosphate through glucose and fructose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-621, PMID:15012287] +xref: MetaCyc:PWY-621 +is_a: GO:0005987 ! sucrose catabolic process + +[Term] +id: GO:0061706 +name: glycolytic process from sucrose through glucose and fructose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:dph, GOC:glycolysis, MetaCyc:PWY-1042, PMID:15012287] +xref: MetaCyc:PWY-1042 +is_a: GO:0061615 ! glycolytic process through fructose-6-phosphate +is_a: GO:0061704 ! glycolytic process from sucrose + +[Term] +id: GO:0061707 +name: extracellular exosome macropinocytosis +namespace: biological_process +def: "The single-organism macropinocytosis process that results in the uptake of an extracellular exosome." [GOC:dph, PMID:24951588] +is_a: GO:0044351 ! macropinocytosis +is_a: GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:0061708 +name: tRNA-5-taurinomethyluridine 2-sulfurtransferase +namespace: molecular_function +def: "Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [GOC:dph, PMID:15509579] +xref: MetaCyc:RXN-16821 +xref: Reactome:R-HSA-6787447 "TRMU (MTO2, MTU1) transfers a sulfur atom to 5-taurinomethyluridine-34 in tRNA" +xref: RHEA:47040 +is_a: GO:0016783 ! sulfurtransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0061709 +name: reticulophagy +namespace: biological_process +alt_id: GO:1990766 +def: "The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions." [GOC:autophagy, GOC:dph, PMID:22481944, PMID:24060720, PMID:26040717] +synonym: "autophagy of the endoplasmic reticulum" EXACT [] +synonym: "autophagy of the ER" EXACT [] +synonym: "endoplasmic reticulum autophagy" EXACT [] +synonym: "endoplasmic reticulum degradation" RELATED [] +synonym: "ER autophagy" EXACT [] +synonym: "ER degradation" RELATED [] +synonym: "ER-phagy" EXACT [] +is_a: GO:0061912 ! selective autophagy +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0061710 +name: L-threonylcarbamoyladenylate synthase +namespace: molecular_function +def: "Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O." [EC:2.7.7.87] +xref: EC:2.7.7.87 +xref: MetaCyc:RXN-14569 +xref: RHEA:36407 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0061711 +name: N(6)-L-threonylcarbamoyladenine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA." [EC:2.3.1.234] +xref: EC:2.3.1.234 +xref: MetaCyc:RXN-14570 +xref: Reactome:R-HSA-6784494 "EKC complex threonylcarbamoylates A37 of tRNAs" +xref: RHEA:37059 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0061712 +name: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase +namespace: molecular_function +def: "Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine." [EC:2.8.4.5] +xref: EC:2.8.4.5 +xref: MetaCyc:RXN-14531 +xref: RHEA:37075 +is_a: GO:0035596 ! methylthiotransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0061713 +name: anterior neural tube closure +namespace: biological_process +def: "The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline." [GOC:BHF, GOC:dph, GOC:hal, PMID:17286298] +is_a: GO:0060606 ! tube closure +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0061714 +name: folic acid receptor activity +namespace: molecular_function +def: "Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis." [GOC:BHF, GOC:hal] +synonym: "folate receptor activity" EXACT [] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0061715 +name: miRNA 2'-O-methylation +namespace: biological_process +def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20705645] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0010586 ! miRNA metabolic process + +[Term] +id: GO:0061716 +name: miRNA export from nucleus +namespace: biological_process +def: "The directed movement of a processed miRNA from the nucleus to the cytoplasm." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15738428, PMID:21554756] +is_a: GO:0097064 ! ncRNA export from nucleus +is_a: GO:1990428 ! miRNA transport + +[Term] +id: GO:0061718 +name: glucose catabolic process to pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate." [GOC:dph] +synonym: "glucose catabolism to pyruvate" EXACT [GOC:dph] +is_a: GO:0006007 ! glucose catabolic process +is_a: GO:0006090 ! pyruvate metabolic process + +[Term] +id: GO:0061719 +name: glucose catabolic process to pyruvate utilizing ADP +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions." [GOC:dph, MetaCyc:P341-PWY] +xref: MetaCyc:P341-PWY +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0061718 ! glucose catabolic process to pyruvate + +[Term] +id: GO:0061720 +name: 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA)." [GOC:dph, PMID:24463506] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process +is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process + +[Term] +id: GO:0061721 +name: 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-) +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-)." [GOC:dph, PMID:14602517, PMID:24463506] +xref: MetaCyc:PWY-7446 +is_a: GO:0019694 ! alkanesulfonate metabolic process +is_a: GO:0051143 ! propanediol metabolic process +is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process + +[Term] +id: GO:0061722 +name: sulphoglycolysis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate." [GOC:dph, PMID:24463506] +synonym: "sulfoglycolysis" EXACT [PMID:14602597] +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:0006734 ! NADH metabolic process +is_a: GO:0019674 ! NAD metabolic process +is_a: GO:0046034 ! ATP metabolic process +is_a: GO:1902777 ! 6-sulfoquinovose(1-) catabolic process + +[Term] +id: GO:0061723 +name: glycophagy +namespace: biological_process +def: "The selective autophagy process in which cellular glycogen is delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:21893048] +is_a: GO:0005980 ! glycogen catabolic process +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0061724 +name: lipophagy +namespace: biological_process +def: "The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:23708524, PMID:26076903] +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0061725 +name: cytosolic lipolysis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy] +is_a: GO:0044242 ! cellular lipid catabolic process + +[Term] +id: GO:0061726 +name: mitochondrion disassembly +namespace: biological_process +def: "The disaggregation of a mitochondrion into its constituent components." [GOC:autophagy, PMID:25009776] +synonym: "mitochondrion degradation" EXACT [GOC:autophagy] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0061727 +name: methylglyoxal catabolic process to lactate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." [GOC:dph, PMID:2198020] +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0051596 ! methylglyoxal catabolic process + +[Term] +id: GO:0061728 +name: GDP-mannose biosynthetic process from mannose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose." [GOC:dph, PMID:16339137, PMID:24218558] +is_a: GO:0006013 ! mannose metabolic process +is_a: GO:0009298 ! GDP-mannose biosynthetic process + +[Term] +id: GO:0061729 +name: GDP-mannose biosynthetic process from fructose-6-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate." [GOC:dph, PMID:16339137] +xref: Reactome:R-HSA-446205 "Synthesis of GDP-mannose, Homo sapiens" +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0009298 ! GDP-mannose biosynthetic process +is_a: GO:0019637 ! organophosphate metabolic process + +[Term] +id: GO:0061730 +name: C-rich strand telomeric DNA binding +namespace: molecular_function +def: "Binding to C-rich, single-stranded, telomere-associated DNA." [GOC:dph, GOC:kmv, PMID:18329362] +is_a: GO:0043047 ! single-stranded telomeric DNA binding + +[Term] +id: GO:0061731 +name: ribonucleoside-diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [GOC:dph, GOC:vw, PMID:16756507] +synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [] +synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [] +synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [] +synonym: "class I ribonucleotide reductase activity" RELATED [] +synonym: "class II ribonucleoside-diphosphate reductase activity" RELATED [] +synonym: "class II ribonucleotide reductase activity" RELATED [] +synonym: "class III ribonucleotide reductase activity" RELATED [] +synonym: "nucleoside diphosphate reductase activity" RELATED [] +synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] +synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [] +synonym: "ribonucleotide diphosphate reductase activity" EXACT [] +synonym: "ribonucleotide reductase activity" BROAD [] +synonym: "RNR" RELATED [] +is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor + +[Term] +id: GO:0061732 +name: mitochondrial acetyl-CoA biosynthetic process from pyruvate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA." [GOC:dph, ISBN:0201090910] +xref: Reactome:R-HSA-372342.1 +xref: Reactome:R-HSA-71397.1 +is_a: GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate + +[Term] +id: GO:0061733 +name: peptide-lysine-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide." [GOC:dph] +xref: Reactome:R-HSA-6811508 "ING2-bound EP300 acetylates TP53" +xref: Reactome:R-HSA-8951966 "EP300 acetylates RUNX3" +xref: Reactome:R-HSA-9617758 "EP300,CREBBP acetylate FOXO4" +xref: Reactome:R-HSA-9620515 "KAT2B,EP300 acetylate FOXO3 under oxidative stress" +xref: Reactome:R-HSA-9626945 "CREBBP acetylates FOXO1" +is_a: GO:0034212 ! peptide N-acetyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0061734 +name: parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190] +synonym: "Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +synonym: "PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +is_a: GO:0098779 ! positive regulation of mitophagy in response to mitochondrial depolarization + +[Term] +id: GO:0061735 +name: DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:25349190] +synonym: "dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +is_a: GO:0098779 ! positive regulation of mitophagy in response to mitochondrial depolarization + +[Term] +id: GO:0061736 +name: engulfment of target by autophagosome +namespace: biological_process +def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] +is_a: GO:0010324 ! membrane invagination +relationship: part_of GO:0000045 ! autophagosome assembly + +[Term] +id: GO:0061737 +name: leukotriene signaling pathway +namespace: biological_process +def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dph, PMID:21771892] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0061738 +name: late endosomal microautophagy +namespace: biological_process +def: "The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:21238931] +is_a: GO:0006914 ! autophagy + +[Term] +id: GO:0061739 +name: protein lipidation involved in autophagosome assembly +namespace: biological_process +def: "The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly." [GOC:autophagy, GOC:dph, PMID:11096062, PMID:11100732, PMID:15277523] +is_a: GO:0006501 ! C-terminal protein lipidation +relationship: part_of GO:0000045 ! autophagosome assembly + +[Term] +id: GO:0061740 +name: protein targeting to lysosome involved in chaperone-mediated autophagy +namespace: biological_process +def: "The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor." [GOC:dph, GOC:pad, GOC:PARL, PMID:22748206] +is_a: GO:0006622 ! protein targeting to lysosome +is_a: GO:0071211 ! protein targeting to vacuole involved in autophagy +relationship: part_of GO:0061684 ! chaperone-mediated autophagy + +[Term] +id: GO:0061741 +name: obsolete chaperone-mediated protein transport involved in chaperone-mediated autophagy +namespace: biological_process +def: "OBSOLETE. The chaperone-mediated protein transport process in which a protein that is bound to a chaperone and a lysosomal receptor is unfolded and transported into the lysosome as part of chaperone-mediated autophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, PMID:22748206] +comment: This term was obsoleted because it represents a function within a process. +is_obsolete: true + +[Term] +id: GO:0061742 +name: chaperone-mediated autophagy translocation complex +namespace: cellular_component +def: "A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy." [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626] +synonym: "chaperone-mediated autophagy receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL] +synonym: "CMA receptor complex" RELATED [GOC:dph, GOC:pad, GOC:PARL] +synonym: "CMA translocation complex" EXACT [GOC:dph, GOC:pad, GOC:PARL, PMID:20797626] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0061743 +name: motor learning +namespace: biological_process +def: "Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience." [GOC:bf, GOC:PARL, Wikipedia:Motor_learning] +is_a: GO:0007612 ! learning + +[Term] +id: GO:0061744 +name: motor behavior +namespace: biological_process +def: "The specific neuromuscular movement of a single organism in response to external or internal stimuli." [GOC:bf, GOC:PARL, PMID:25318560] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0061746 +name: obsolete single-stranded DNA-dependent GTPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:dph, PMID:26277776] +comment: This term was obsoleted because there is no evidence that this reaction occurs under physiological conditions. +is_obsolete: true + +[Term] +id: GO:0061749 +name: forked DNA-dependent helicase activity +namespace: molecular_function +def: "Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis." [GOC:dph, PMID:26277776] +is_a: GO:0003678 ! DNA helicase activity + +[Term] +id: GO:0061750 +name: acid sphingomyelin phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment." [GOC:dph, PMID:26493087] +synonym: "acid SMase" RELATED [PMID:26493087] +synonym: "acid sphingomyelinase" EXACT [PMID:26493087] +is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity + +[Term] +id: GO:0061751 +name: neutral sphingomyelin phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in a neutral environment." [GOC:dph, PMID:26493087] +synonym: "neutral SMase" EXACT [PMID:26493087] +synonym: "neutral sphingomyelinase" EXACT [GOC:26493087] +is_a: GO:0004767 ! sphingomyelin phosphodiesterase activity + +[Term] +id: GO:0061752 +name: telomeric repeat-containing RNA binding +namespace: molecular_function +def: "Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats." [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916] +synonym: "TERRA binding" EXACT [PMID:20655916] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0061753 +name: substrate localization to autophagosome +namespace: biological_process +def: "The localization process by which an autophagic substrate is delivered to a forming autophagosome." [GOC:dph, GOC:pad, GOC:PARL, PMID:23545414] +synonym: "substrate sequestration to autophagosome" EXACT [] +synonym: "substrate sequestration to phagophore" EXACT [] +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0000045 ! autophagosome assembly + +[Term] +id: GO:0061754 +name: negative regulation of circulating fibrinogen levels +namespace: biological_process +def: "Any process that reduces the quantity of fibrinogen circulating in the bloodstream." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:20570858] +is_a: GO:0044537 ! regulation of circulating fibrinogen levels + +[Term] +id: GO:0061755 +name: positive regulation of circulating fibrinogen levels +namespace: biological_process +def: "Any process that increases the quantity of fibrinogen circulating in the bloodstream." [GOC:bf, GOC:BHF, GOC:BHF_miRNA, PMID:20570858] +is_a: GO:0044537 ! regulation of circulating fibrinogen levels + +[Term] +id: GO:0061756 +name: leukocyte adhesion to vascular endothelial cell +namespace: biological_process +def: "The attachment of a leukocyte to vascular endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:23897866] +is_a: GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:0061757 +name: leukocyte adhesion to arterial endothelial cell +namespace: biological_process +def: "The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules." [GOC:add, GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22267480] +is_a: GO:0061756 ! leukocyte adhesion to vascular endothelial cell + +[Term] +id: GO:0061758 +name: 2-hydroxyglutarate dehydrogenase activity, forward reaction +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor." [EC:1.1.99.2, GOC:dph, MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN] +synonym: "alpha-ketoglutarate reductase activity, reverse reaction" EXACT [GOC:dph] +xref: RHEA:21253 +is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity + +[Term] +id: GO:0061759 +name: alpha-ketoglutarate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor." [EC:1.1.99.2, GOC:dph, PMID:26774271, RHEA:21254] +synonym: "2-hydroxyglutarate dehydrogenase activity, reverse reaction" EXACT [GOC:dph] +synonym: "2-ketoglutarate reductase activity" RELATED [GOC:dph] +synonym: "2-oxoglutarate reductase activity" RELATED [GOC:dph] +synonym: "D-2HG reductase activity" RELATED [GOC:dph] +xref: RHEA:21254 +is_a: GO:0047545 ! 2-hydroxyglutarate dehydrogenase activity + +[Term] +id: GO:0061760 +name: antifungal innate immune response +namespace: biological_process +def: "An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [GOC:dph, PMID:22470487] +is_a: GO:0045087 ! innate immune response +is_a: GO:0050832 ! defense response to fungus + +[Term] +id: GO:0061761 +name: alpha-latrotoxin receptor binding +namespace: molecular_function +def: "Binding to an alpha-latrotoxin receptor." [GOC:dph, PMID:21724987] +synonym: "lasso receptor binding" EXACT [GOC:dph, PMID:21724987] +synonym: "latrophilin binding" EXACT [GOC:dph, PMID:21724987] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0061762 +name: CAMKK-AMPK signaling cascade +namespace: biological_process +def: "A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity." [GOC:dph, GOC:pad, GOC:PARL, PMID:23010169, PMID:24709372] +synonym: "stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:dph] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0099004 ! calmodulin dependent kinase signaling pathway + +[Term] +id: GO:0061763 +name: multivesicular body-lysosome fusion +namespace: biological_process +def: "The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle." [GOC:dph, GOC:pad, GOC:PARL, PMID:21118109] +synonym: "fusion of multivesicular body to lysosome" EXACT [GOC:dph] +synonym: "fusion of MVB to lysosome" EXACT [GOC:dph] +synonym: "MVB-lysosome fusion" EXACT [GOC:dph] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0097212 ! lysosomal membrane organization +relationship: part_of GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway + +[Term] +id: GO:0061764 +name: late endosome to lysosome transport via multivesicular body sorting pathway +namespace: biological_process +def: "The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:dph] +is_a: GO:0032510 ! endosome to lysosome transport via multivesicular body sorting pathway +is_a: GO:0045324 ! late endosome to vacuole transport +is_a: GO:1902774 ! late endosome to lysosome transport + +[Term] +id: GO:0061765 +name: modulation by virus of host NIK/NF-kappaB cascade +namespace: biological_process +def: "Any process in which a virus effect a change in the frequency, rate or extent of NIK/NF-kappaB signaling in the host." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:26764146] +synonym: "modulation by virus of host NIK/NF-kappaB signaling" EXACT [] +is_a: GO:0085032 ! modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0061766 +name: positive regulation of lung blood pressure +namespace: biological_process +def: "The process that increases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:22161164] +synonym: "positive regulation of pulmonary blood pressure" EXACT [GOC:dph] +is_a: GO:0014916 ! regulation of lung blood pressure + +[Term] +id: GO:0061767 +name: negative regulation of lung blood pressure +namespace: biological_process +def: "The process that decreases the force with which blood travels through the lungs." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:dph, PMID:22161164] +synonym: "negative regulation of pulmonary blood pressure" EXACT [GOC:dph] +is_a: GO:0014916 ! regulation of lung blood pressure + +[Term] +id: GO:0061768 +name: magnesium:sodium antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in)." [GOC:pad, GOC:PARL, PMID:22031603] +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0061769 +name: ribosylnicotinate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H(+) + nicotinate mononucleotide." [GOC:dph, PMID:17914902] +xref: Reactome:R-HSA-8869606 "NMRK1 phosphorylates NAR to yield NAMN" +xref: Reactome:R-HSA-8869607 "NMRK2 phosphorylates NAR to yield NAMN" +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0061770 +name: translation elongation factor binding +namespace: molecular_function +def: "Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation." [GOC:dph] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0061771 +name: response to caloric restriction +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake." [GOC:dph, PMID:15520862] +is_a: GO:0006950 ! response to stress +is_a: GO:0031667 ! response to nutrient levels + +[Term] +id: GO:0061772 +name: xenobiotic transport across blood-nerve barrier +namespace: biological_process +def: "The directed movement of a xenobiotic through the blood-nerve barrier." [GOC:dph, PMID:22733753] +synonym: "drug transport across blood-nerve barrier" RELATED [] +synonym: "drug transport across perineurial barrier" EXACT [PMID:22733753] +is_a: GO:0042908 ! xenobiotic transport + +[Term] +id: GO:0061773 +name: eNoSc complex +namespace: cellular_component +def: "A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation." [GOC:BHM, Intact:EBI-11789632, Intact:EBI-11790279, PMID:18485871] +synonym: "energy dependent nucleolar silencing complex" EXACT [] +is_a: GO:0005677 ! chromatin silencing complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0061774 +name: cohesin unloading +namespace: biological_process +def: "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA." [GOC:dph, GOC:vw, PMID:26687354] +synonym: "DNA exit from the cohesin ring" EXACT [GOC:dph, GOC:vw] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:0045875 ! negative regulation of sister chromatid cohesion + +[Term] +id: GO:0061775 +name: cohesin loading activity +namespace: molecular_function +def: "Facilitating a conformational change to load a cohesin complex around sister chromatids, driven by ATP hydrolysis." [GOC:vw, PMID:26687354] +synonym: "ATP-dependent cohesin loading activity" EXACT [] +synonym: "cohesin ATPase activity" EXACT [] +synonym: "cohesin loading ATPase" EXACT [] +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0061776 +name: topological DNA co-entrapment activity +namespace: molecular_function +def: "A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring." [GOC:dph, GOC:vw, PMID:16179255, PMID:26687354, PMID:27797071] +synonym: "topological DNA entrapment activity" RELATED [] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0061777 +name: obsolete DNA clamp activity +namespace: molecular_function +def: "OBSOLETE. A DNA binding activity in which a protein complex interacts selectively and non-covalently with single DNA duplex to tightly encircle the DNA." [GOC:dph, GOC:vw, PMID:1349852] +comment: The reason for obsoletion is that the term captures the structure of a complex, not a specific function. +is_obsolete: true + +[Term] +id: GO:0061778 +name: intracellular chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:dph, PMID:23092411] +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0061779 +name: Tapasin-ERp57 complex +namespace: cellular_component +def: "Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role." [GOC:bhm, GOC:dph, Intact:EBI-11896237, Intact:EBI-9013963, PMID:17603487] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0042824 ! MHC class I peptide loading complex + +[Term] +id: GO:0061780 +name: mitotic cohesin loading +namespace: biological_process +def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:vw] +is_a: GO:0071921 ! cohesin loading +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0034087 ! establishment of mitotic sister chromatid cohesion + +[Term] +id: GO:0061781 +name: mitotic cohesin unloading +namespace: biological_process +def: "Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:vw] +is_a: GO:0061774 ! cohesin unloading +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:0061782 +name: vesicle fusion with vesicle +namespace: biological_process +def: "Fusion of the membrane of a transport vesicle with a target membrane on another vesicle." [GOC:bf, GOC:PARL, PMID:16618809] +synonym: "vesicle to vesicle fusion" EXACT [GOC:dph] +synonym: "vesicle-vesicle fusion" EXACT [GOC:dph] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:0061783 +name: peptidoglycan muralytic activity +namespace: molecular_function +def: "A catalytic activity that contributes to the degradation of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0061784 +name: peptidoglycan N-acetylglucosaminidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] +is_a: GO:0015929 ! hexosaminidase activity +is_a: GO:0061783 ! peptidoglycan muralytic activity + +[Term] +id: GO:0061785 +name: peptidoglycan endopeptidase activity +namespace: molecular_function +def: "An endopeptidase activity that uses peptidoglycan as a substrate." [GOC:dph, GOC:jh, PMID:22748813] +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0061783 ! peptidoglycan muralytic activity + +[Term] +id: GO:0061786 +name: peptidoglycan stem peptide endopeptidase activity +namespace: molecular_function +def: "A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan." [GOC:dph, GOC:jh, PMID:22748813] +is_a: GO:0061785 ! peptidoglycan endopeptidase activity + +[Term] +id: GO:0061787 +name: peptidoglycan cross-bridge peptide endopeptidase activity +namespace: molecular_function +def: "A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge." [GOC:dph, GOC:jh, PMID:22748813] +synonym: "lysostaphin activity" NARROW [GOC:dph, GOC:jh, PMID:22748813] +is_a: GO:0061785 ! peptidoglycan endopeptidase activity + +[Term] +id: GO:0061788 +name: EGF repeat binding +namespace: molecular_function +def: "Binding to Epidermal Growth Factor (EGF) repeats." [GOC:25700513, GOC:dph, PMID:25155514] +synonym: "Epidermal growth factor domain binding" BROAD [GOC:dph] +synonym: "Epidermal Growth Factor repeat binding" RELATED [GOC:dph] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0061789 +name: dense core granule priming +namespace: biological_process +def: "A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking." [GOC:bf, GOC:PARL, PMID:10899113, PMID:26575293] +synonym: "dense core vesicle priming" EXACT [PMID:26575293] +synonym: "large dense-core vesicle priming" EXACT [PMID:10899113] +synonym: "LDCV priming" EXACT [PMID:26575293] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:0061790 +name: dense core granule docking +namespace: biological_process +def: "The initial attachment of a dense core granule membrane to the plasma membrane." [GOC:bf, GOC:PARL, PMID:26575293] +is_a: GO:0006904 ! vesicle docking involved in exocytosis +relationship: part_of GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:0061791 +name: GTPase motor activity +namespace: molecular_function +def: "A motor activity driven by GTP hydrolysis." [GOC:dph, GOC:vw, PMID:11242086] +is_a: GO:0003774 ! cytoskeletal motor activity +is_a: GO:0003924 ! GTPase activity + +[Term] +id: GO:0061792 +name: secretory granule maturation +namespace: biological_process +def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] +is_a: GO:0021700 ! developmental maturation +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0061793 +name: chromatin lock complex +namespace: cellular_component +def: "A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping." [GOC:bhm, GOC:dph, PMID:17540172] +synonym: "nucleosome bridging complex" RELATED [GOC:dph] +is_a: GO:0005677 ! chromatin silencing complex + +[Term] +id: GO:0061794 +name: conidium development +namespace: biological_process +def: "The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:dph] +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0061795 +name: Golgi lumen acidification +namespace: biological_process +def: "Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion." [GOC:dph, PMID:23447592] +is_a: GO:0051452 ! intracellular pH reduction + +[Term] +id: GO:0061796 +name: membrane addition at site of mitotic cytokinesis +namespace: biological_process +def: "A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:dph, GOC:vw] +is_a: GO:0007107 ! membrane addition at site of cytokinesis +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:0061797 +name: pH-gated chloride channel activity +namespace: molecular_function +def: "A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH." [GOC:dph, PMID:27358471] +is_a: GO:0005254 ! chloride channel activity +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0061798 +name: GTP 3',8'-cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate." [GOC:dph, GOC:ik, PMID:25896388] +xref: EC:4.1.99.22 +xref: MetaCyc:RXN-8340 +xref: RHEA:49576 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0061799 +name: cyclic pyranopterin monophosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate." [GOC:dph, GOC:ik, PMID:25896388] +xref: EC:4.6.1.17 +xref: MetaCyc:RXN-17809 +xref: RHEA:49580 +is_a: GO:0016849 ! phosphorus-oxygen lyase activity + +[Term] +id: GO:0061800 +name: fibronectin fibril +namespace: cellular_component +def: "A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks." [GOC:dph, PMID:20690820] +is_a: GO:0099512 ! supramolecular fiber +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:0061801 +name: laminin-5B complex +namespace: cellular_component +def: "A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains." [GOC:dph, PMID:15979864] +synonym: "laminin 3B32 complex" EXACT [PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:0061802 +name: anterior cell cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis." [GOC:15666355, GOC:17981131, GOC:dph, GOC:kmv] +is_a: GO:0099738 ! cell cortex region + +[Term] +id: GO:0061803 +name: posterior cell cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis." [GOC:dph, GOC:kmv, PMID:15666355, PMID:17981131] +is_a: GO:0099738 ! cell cortex region + +[Term] +id: GO:0061804 +name: mitotic spindle formation (spindle phase one) +namespace: biological_process +def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase." [GOC:dph, GOC:vw, PMID:21920317] +synonym: "mitotic spindle elongation during mitotic prophase" EXACT [] +synonym: "mitotic spindle elongation during prophase" EXACT [] +synonym: "mitotic spindle elongation during prophase and prometaphase" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization +relationship: part_of GO:0000022 ! mitotic spindle elongation +relationship: part_of GO:0090307 ! mitotic spindle assembly + +[Term] +id: GO:0061805 +name: mitotic spindle elongation (spindle phase three) +namespace: biological_process +def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B." [GOC:dph, GOC:vw, PMID:21920317] +synonym: "mitotic anaphase spindle elongation" EXACT [] +synonym: "mitotic spindle elongation during anaphase" EXACT [] +synonym: "mitotic spindle elongation during mitotic anaphase" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization +relationship: part_of GO:0000022 ! mitotic spindle elongation + +[Term] +id: GO:0061806 +name: regulation of DNA recombination at centromere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA." [GOC:dph, GOC:mah, PMID:27697832] +synonym: "regulation of centromeric recombination" EXACT [GOC:mah] +is_a: GO:0000018 ! regulation of DNA recombination + +[Term] +id: GO:0061807 +name: positive regulation of DNA recombination at centromere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere." [GOC:dph, GOC:mah] +synonym: "positive regulation of centromeric recombination" EXACT [GOC:mah] +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:0061806 ! regulation of DNA recombination at centromere + +[Term] +id: GO:0061808 +name: negative regulation of DNA recombination at centromere +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere." [GOC:dph, GOC:mah] +synonym: "negative regulation of centromeric recombination" EXACT [GOC:dph] +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:0061806 ! regulation of DNA recombination at centromere + +[Term] +id: GO:0061809 +name: NAD+ nucleotidase, cyclic ADP-ribose generating +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] +xref: EC:3.2.2.6 +xref: MetaCyc:NADNUCLEOSID-RXN +is_a: GO:0003953 ! NAD+ nucleosidase activity + +[Term] +id: GO:0061810 +name: NAD glycohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] +xref: EC:3.2.2.5 +xref: Reactome:R-HSA-9637699 "CpnT hydrolyses NAD+" +is_a: GO:0003953 ! NAD+ nucleosidase activity + +[Term] +id: GO:0061811 +name: ADP-ribosyl cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528] +is_a: GO:0009975 ! cyclase activity + +[Term] +id: GO:0061812 +name: cyclic ADP-ribose hydrolase +namespace: molecular_function +def: "Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR)." [GOC:dph, GOC:pad, GOC:PARL, PMID:11866528] +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0061813 +name: obsolete ARID domain binding +namespace: molecular_function +def: "OBSOLETE. Binding to a ARID domain. The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors." [GOC:dph, InterPro:IPR001606, PMID:18270511] +is_obsolete: true + +[Term] +id: GO:0061815 +name: deubiquitinase, acting on linear ubiquitin +namespace: molecular_function +def: "Catalysis of the hydrolysis of ubiquitin units from linear ubiquitin chains." [GOC:dph, PMID:26503766, PMID:27702987] +synonym: "linear ubiquitin specific deubiquitinase activity" EXACT [] +synonym: "Met1 linkage specific DUB" EXACT [] +synonym: "ubiquitinyl hydrolase activity, acting on linear ubiquitin" EXACT [] +is_a: GO:0101005 ! deubiquitinase activity + +[Term] +id: GO:0061816 +name: proteaphagy +namespace: biological_process +def: "The selective autophagy process that clears 26S proteasomes; homeostatic mechanism within the ubiquitin system that modulates proteolytic capacity and eliminates damaged particles." [GOC:dph, GOC:se, PMID:26670610, PMID:27477278] +is_a: GO:0035973 ! aggrephagy + +[Term] +id: GO:0061817 +name: endoplasmic reticulum-plasma membrane tethering +namespace: biological_process +def: "The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers." [GOC:dph, GOC:vw, PMID:23237950, PMID:26877082, PMID:27875684] +synonym: "ER-plasma membrane tethering" EXACT [GOC:dph] +is_a: GO:0051643 ! endoplasmic reticulum localization +is_a: GO:0140056 ! organelle localization by membrane tethering + +[Term] +id: GO:0061818 +name: tRNA folding +namespace: biological_process +def: "The process of assisting in the folding of tRNAs into the correct tertiary structure." [GOC:dph, PMID:27849601] +is_a: GO:0034337 ! RNA folding + +[Term] +id: GO:0061819 +name: telomeric DNA-containing double minutes formation +namespace: biological_process +def: "A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:14690602, PMID:2397458] +synonym: "TDMs formation" EXACT [] +is_a: GO:0000722 ! telomere maintenance via recombination + +[Term] +id: GO:0061820 +name: telomeric D-loop disassembly +namespace: biological_process +def: "A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:10338204, PMID:24012755] +is_a: GO:0090657 ! telomeric loop disassembly + +[Term] +id: GO:0061821 +name: telomeric D-loop binding +namespace: molecular_function +def: "Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19734539] +synonym: "telomeric Displacement-loop binding" EXACT [] +is_a: GO:0062037 ! D-loop DNA binding + +[Term] +id: GO:0061822 +name: ciliary cap +namespace: cellular_component +def: "An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole." [PMID:25447994, PMID:27646273] +synonym: "spermatid ciliary cap" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0061823 +name: ring centriole +namespace: cellular_component +def: "A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum." [PMID:25447994, PMID:4903810] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0061824 +name: cytosolic ciliogenesis +namespace: biological_process +def: "The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm." [PMID:25447994, PMID:26654377] +synonym: "intracellular ciliogenesis" RELATED [] +is_a: GO:0060271 ! cilium assembly + +[Term] +id: GO:0061825 +name: podosome core +namespace: cellular_component +def: "The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [PMID:23158496] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0002102 ! podosome + +[Term] +id: GO:0061826 +name: podosome ring +namespace: cellular_component +def: "The ring structure surrounding the podosome core, containing proteins such as vinculin and talin." [PMID:23158496] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0002102 ! podosome + +[Term] +id: GO:0061827 +name: sperm head +namespace: cellular_component +def: "The part of the late spermatid or spermatozoon that contains the nucleus and acrosome." [PMID:22797892, PMID:24665388] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0061828 +name: apical tubulobulbar complex +namespace: cellular_component +def: "Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [PMID:20403871, PMID:22510523] +synonym: "apical TBC" EXACT [] +is_a: GO:0036284 ! tubulobulbar complex + +[Term] +id: GO:0061829 +name: basal tubulobulbar complex +namespace: cellular_component +def: "Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell." [PMID:20403871, PMID:22510523] +synonym: "basal TBC" EXACT [] +is_a: GO:0036284 ! tubulobulbar complex + +[Term] +id: GO:0061830 +name: concave side of sperm head +namespace: cellular_component +def: "The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species." [PMID:22332112, PMID:23403943, PMID:26990065] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0061827 ! sperm head + +[Term] +id: GO:0061831 +name: apical ectoplasmic specialization +namespace: cellular_component +def: "Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604] +synonym: "apical ES" EXACT [] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0061832 +name: basal ectoplasmic specialization +namespace: cellular_component +def: "Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell." [GOC:aruk, GOC:bc, GOC:dph, PMID:22332112, PMID:23546604] +synonym: "basal ES" EXACT [] +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0061833 +name: protein localization to tricellular tight junction +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction." [PMID:24889144] +is_a: GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0061834 +name: actin filament branch point +namespace: cellular_component +def: "The part of an actin filament where the structure forks." [PMID:18256280] +synonym: "microfilament branch point" EXACT [GOC:dph] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005884 ! actin filament + +[Term] +id: GO:0061835 +name: ventral surface of cell +namespace: cellular_component +def: "The surface of a migrating cell that is in contact with the substratum or cell layer." [PMID:11598004] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0061836 +name: intranuclear rod +namespace: cellular_component +def: "A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions." [PMID:28074884] +synonym: "intranuclear actin rod" EXACT [] +is_a: GO:0099512 ! supramolecular fiber + +[Term] +id: GO:0061837 +name: neuropeptide processing +namespace: biological_process +def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide." [PMID:12657671, PMID:17564681] +is_a: GO:0140448 ! signaling receptor ligand precursor processing + +[Term] +id: GO:0061838 +name: CENP-T-W-S-X complex +namespace: cellular_component +def: "A histone-variant containing protein complex which forms a centromere specific nucleosomal structure, involved in centromeric chromatin organization." [PMID:22304909, PMID:22304917] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0061840 +name: high-affinity ferrous iron transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:bhm, PMID:9413439] +synonym: "high affinity ferrous uptake transmembrane transporter activity" EXACT [] +synonym: "high-affinity ferrous iron uptake transmembrane transporter activity" EXACT [] +is_a: GO:0015093 ! ferrous iron transmembrane transporter activity + +[Term] +id: GO:0061841 +name: high-affinity iron exporter complex +namespace: cellular_component +def: "A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment." [GOC:bhm, PMID:10608875, PMID:9413439] +comment: An example of this is FET5 in Saccharomyces cerevisiae (P43561) in PMID:9413439. +synonym: "FET5-FTH1 high affinity iron exporter complex" NARROW [] +synonym: "FET5-FTH1 high-affinity iron exporter complex" NARROW [] +synonym: "high affinity iron exporter complex" EXACT [] +is_a: GO:1902495 ! transmembrane transporter complex +is_a: GO:1905862 ! ferroxidase complex +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0061842 +name: microtubule organizing center localization +namespace: biological_process +def: "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell." [PMID:21281821] +synonym: "microtubule organizing center polarity" NARROW [] +synonym: "MTOC localization" EXACT [] +synonym: "MTOC polarity" NARROW [] +is_a: GO:0009987 ! cellular process +is_a: GO:0051179 ! localization + +[Term] +id: GO:0061843 +name: Sertoli cell barrier remodeling +namespace: biological_process +def: "The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle." [PMID:20534520, PMID:24467744] +synonym: "blood testis barrier restructuring" BROAD [] +synonym: "restructuring of blood-testis barrier" BROAD [] +synonym: "restructuring of BTB" BROAD [] +synonym: "restructuring of SCB" EXACT [] +synonym: "SCB remodeling" EXACT [] +synonym: "Sertoli cell barrier restructuring" EXACT [] +is_a: GO:0048771 ! tissue remodeling + +[Term] +id: GO:0061844 +name: antimicrobial humoral immune response mediated by antimicrobial peptide +namespace: biological_process +def: "An immune response against microbes mediated by anti-microbial peptides in body fluid." [PMID:15761415, PMID:24287494] +synonym: "antimicrobial peptide-mediated antimicrobial humoral response" EXACT [] +synonym: "peptide-mediated antimicrobial humoral response" BROAD [] +is_a: GO:0019730 ! antimicrobial humoral response + +[Term] +id: GO:0061845 +name: neuron projection branch point +namespace: cellular_component +def: "The location where a secondary projection arises from a neuron projection." [PMID:25586189] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043005 ! neuron projection + +[Term] +id: GO:0061846 +name: dendritic spine cytoplasm +namespace: cellular_component +def: "The region of the neuronal cytoplasm located in dendritic spines." [PMID:15673667] +is_a: GO:0032839 ! dendrite cytoplasm +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0061847 +name: response to cholecystokinin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0061848 +name: cellular response to cholecystokinin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus." [PMID:14622258] +is_a: GO:0061847 ! response to cholecystokinin +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0061849 +name: telomeric G-quadruplex DNA binding +namespace: molecular_function +def: "Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:16142245, PMID:9512530] +is_a: GO:0042162 ! telomeric DNA binding +is_a: GO:0051880 ! G-quadruplex DNA binding + +[Term] +id: GO:0061850 +name: growth cone leading edge +namespace: cellular_component +def: "That part of the growth cone which represents the distal part of the structure." [PMID:10797548] +is_a: GO:0031252 ! cell leading edge +relationship: part_of GO:0090725 ! peripheral region of growth cone + +[Term] +id: GO:0061851 +name: leading edge of lamellipodium +namespace: cellular_component +def: "That part of the lamellipodium which represents the distal part of the structure." [PMID:22339865] +is_a: GO:0031252 ! cell leading edge +relationship: part_of GO:0030027 ! lamellipodium + +[Term] +id: GO:0061852 +name: retrograte transporter complex, Golgi to ER +namespace: cellular_component +def: "Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles." [GOC:bhm, PMID:16093310] +comment: An example of this is ERV41 in Saccharomyces cerevisiae (Q04651) in PMID:16093310 (inferred from direct assay). +synonym: "ERV41-ERV46 retrograde receptor complex" NARROW [] +synonym: "retrograte receptor complex, Golgi to endoplasmic reticulum" EXACT [] +synonym: "retrograte receptor complex, Golgi to ER" EXACT [] +synonym: "retrograte transporter complex, Golgi to endoplasmic reticulum" EXACT [] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:0061853 +name: regulation of neuroblast migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuroblast migration." [PMID:23149556] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0097402 ! neuroblast migration + +[Term] +id: GO:0061854 +name: positive regulation of neuroblast migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuroblast migration." [PMID:23149556] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0061853 ! regulation of neuroblast migration +relationship: positively_regulates GO:0097402 ! neuroblast migration + +[Term] +id: GO:0061855 +name: negative regulation of neuroblast migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration." [PMID:23149556] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0061853 ! regulation of neuroblast migration +relationship: negatively_regulates GO:0097402 ! neuroblast migration + +[Term] +id: GO:0061856 +name: Golgi calcium ion transmembrane transport +namespace: biological_process +def: "A process in which a calcium ion is transported from one side of a Golgi membrane to the other by means of some agent such as a transporter or pore." [PMID:21811607] +is_a: GO:0032472 ! Golgi calcium ion transport +is_a: GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:0061857 +name: endoplasmic reticulum stress-induced pre-emptive quality control +namespace: biological_process +def: "The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome." [PMID:17129784, PMID:26565908] +synonym: "ER pQC" EXACT [] +synonym: "ER stress-indiced pre-emptive quality control" EXACT [] +is_a: GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:0061860 +name: DNA clamp unloader activity +namespace: molecular_function +def: "Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis." [GOC:vw, PMID:23499004] +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0061862 +name: cellular response to differentiation-inducing factor 2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [PMID:19684855] +synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT [] +synonym: "cellular response to DIF-2" RELATED [] +synonym: "cellular response to DIF2" RELATED [] +is_a: GO:0051716 ! cellular response to stimulus +is_a: GO:1905960 ! response to differentiation-inducing factor 2 + +[Term] +id: GO:0061863 +name: microtubule plus end polymerase +namespace: molecular_function +def: "Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers." [PMID:27872152] +is_a: GO:0016740 ! transferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0061864 +name: basement membrane constituent secretion +namespace: biological_process +def: "The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell." [PMID:26610918, PMID:28228250] +is_a: GO:0070278 ! extracellular matrix constituent secretion + +[Term] +id: GO:0061865 +name: polarized secretion of basement membrane proteins in epithelium +namespace: biological_process +def: "The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium." [PMID:26610918, PMID:28228250] +is_a: GO:0061864 ! basement membrane constituent secretion + +[Term] +id: GO:0061866 +name: negative regulation of histone H3-S10 phosphorylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of one or more phosphate groups to histone H3 on a serine residue at position 10." [PMID:27521428] +is_a: GO:0033128 ! negative regulation of histone phosphorylation +is_a: GO:0033137 ! negative regulation of peptidyl-serine phosphorylation +relationship: negatively_regulates GO:0043987 ! histone H3-S10 phosphorylation + +[Term] +id: GO:0061867 +name: establishment of mitotic spindle asymmetry +namespace: biological_process +def: "The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure." [PMID:26659188] +is_a: GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0061868 +name: hepatic stellate cell migration +namespace: biological_process +def: "The orderly movement of a hepatic stellate cell from one site to another." [PMID:24204762] +is_a: GO:0010761 ! fibroblast migration + +[Term] +id: GO:0061869 +name: regulation of hepatic stellate cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] +is_a: GO:0010762 ! regulation of fibroblast migration +relationship: regulates GO:0061868 ! hepatic stellate cell migration + +[Term] +id: GO:0061870 +name: positive regulation of hepatic stellate cell migration +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] +is_a: GO:0010763 ! positive regulation of fibroblast migration +is_a: GO:0061869 ! regulation of hepatic stellate cell migration +relationship: positively_regulates GO:0061868 ! hepatic stellate cell migration + +[Term] +id: GO:0061871 +name: negative regulation of hepatic stellate cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration." [PMID:24204762] +is_a: GO:0010764 ! negative regulation of fibroblast migration +is_a: GO:0061869 ! regulation of hepatic stellate cell migration +relationship: negatively_regulates GO:0061868 ! hepatic stellate cell migration + +[Term] +id: GO:0061872 +name: hepatic stellate cell contraction +namespace: biological_process +def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell." [PMID:24204762] +is_a: GO:0070252 ! actin-mediated cell contraction + +[Term] +id: GO:0061873 +name: regulation of hepatic stellate cell contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: regulates GO:0061872 ! hepatic stellate cell contraction + +[Term] +id: GO:0061874 +name: positive regulation of hepatic stellate cell contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] +is_a: GO:0061873 ! regulation of hepatic stellate cell contraction +is_a: GO:1903116 ! positive regulation of actin filament-based movement +relationship: positively_regulates GO:0061872 ! hepatic stellate cell contraction + +[Term] +id: GO:0061875 +name: negative regulation of hepatic stellate cell contraction +namespace: biological_process +def: "Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction." [PMID:24204762] +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0061873 ! regulation of hepatic stellate cell contraction +relationship: negatively_regulates GO:0061872 ! hepatic stellate cell contraction + +[Term] +id: GO:0061880 +name: regulation of anterograde axonal transport of mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] +synonym: "regulation of anterograde axon transport of mitochondria" EXACT [] +is_a: GO:1902513 ! regulation of organelle transport along microtubule +relationship: regulates GO:0098957 ! anterograde axonal transport of mitochondrion + +[Term] +id: GO:0061881 +name: positive regulation of anterograde axonal transport of mitochondrion +namespace: biological_process +def: "Any process that activates or increasesthe frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] +synonym: "positive regulation of anterograde axon transport of mitochondria" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion +relationship: positively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion + +[Term] +id: GO:0061882 +name: negative regulation of anterograde axonal transport of mitochondrion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [PMID:24302729] +synonym: "negative regulation of anterograde axon transport of mitochondria" EXACT [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0061880 ! regulation of anterograde axonal transport of mitochondrion +relationship: negatively_regulates GO:0098957 ! anterograde axonal transport of mitochondrion + +[Term] +id: GO:0061883 +name: clathrin-dependent endocytosis involved in vitellogenesis +namespace: biological_process +def: "A clathrin-mediated endocytosis process whereby yolk proteins are internalized and trafficked through the endocytic pathway for yolk deposition." [PMID:26265702] +synonym: "clathrin-dependent endocytosis involved in yolk formation" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0072583 ! clathrin-dependent endocytosis +relationship: part_of GO:0007296 ! vitellogenesis + +[Term] +id: GO:0061884 +name: regulation of mini excitatory postsynaptic potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] +is_a: GO:0098815 ! modulation of excitatory postsynaptic potential +relationship: regulates GO:0098816 ! mini excitatory postsynaptic potential + +[Term] +id: GO:0061885 +name: positive regulation of mini excitatory postsynaptic potential +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] +is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential +is_a: GO:2000463 ! positive regulation of excitatory postsynaptic potential +relationship: positively_regulates GO:0098816 ! mini excitatory postsynaptic potential + +[Term] +id: GO:0061886 +name: negative regulation of mini excitatory postsynaptic potential +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:aruk, GOC:bc, PMID:20395454] +is_a: GO:0061884 ! regulation of mini excitatory postsynaptic potential +is_a: GO:0090394 ! negative regulation of excitatory postsynaptic potential +relationship: negatively_regulates GO:0098816 ! mini excitatory postsynaptic potential + +[Term] +id: GO:0061887 +name: obsolete reproduction of symbiont in host +namespace: biological_process +def: "OBSOLETE. The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms, occurring within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23460907, PMID:25713147] +comment: This term was obsoleted because it represents a process and a component. +is_obsolete: true + +[Term] +id: GO:0061888 +name: regulation of astrocyte activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] +is_a: GO:0048710 ! regulation of astrocyte differentiation +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0048143 ! astrocyte activation + +[Term] +id: GO:0061889 +name: negative regulation of astrocyte activation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] +is_a: GO:0048712 ! negative regulation of astrocyte differentiation +is_a: GO:0050866 ! negative regulation of cell activation +is_a: GO:0061888 ! regulation of astrocyte activation +is_a: GO:0150079 ! negative regulation of neuroinflammatory response +relationship: negatively_regulates GO:0048143 ! astrocyte activation + +[Term] +id: GO:0061890 +name: positive regulation of astrocyte activation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of astrocyte activation." [GOC:aruk, GOC:bc, PMID:20005821] +is_a: GO:0048711 ! positive regulation of astrocyte differentiation +is_a: GO:0050867 ! positive regulation of cell activation +is_a: GO:0061888 ! regulation of astrocyte activation +is_a: GO:0150078 ! positive regulation of neuroinflammatory response +relationship: positively_regulates GO:0048143 ! astrocyte activation + +[Term] +id: GO:0061891 +name: calcium ion sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+)." [PMID:16005298, PMID:17020874, PMID:28151650] +is_a: GO:0005509 ! calcium ion binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0061896 +name: all-trans retinol 3,4-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] +xref: RHEA:50292 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0061897 +name: all-trans retinal 3,4-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0061898 +name: all-trans retinoic acid 3,4-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinoic acid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0061899 +name: 11-cis-retinal 3,4-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-cis-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]." [PMID:27059013] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0061900 +name: glial cell activation +namespace: biological_process +def: "A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:aruk, GOC:bc, PMID:18723082] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0150076 ! neuroinflammatory response + +[Term] +id: GO:0061901 +name: regulation of 1-phosphatidylinositol-3-kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] +is_a: GO:0043551 ! regulation of phosphatidylinositol 3-kinase activity + +[Term] +id: GO:0061902 +name: negative regulation of 1-phosphatidylinositol-3-kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] +is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process +is_a: GO:0043553 ! negative regulation of phosphatidylinositol 3-kinase activity +is_a: GO:0061901 ! regulation of 1-phosphatidylinositol-3-kinase activity + +[Term] +id: GO:0061903 +name: positive regulation of 1-phosphatidylinositol-3-kinase activity +namespace: biological_process +def: "Any process that starts or increases the frequency or rate of 1-phosphatidylinositol-3-kinase activity." [GOC:aruk, GOC:bc, PMID:18723082] +is_a: GO:0043552 ! positive regulation of phosphatidylinositol 3-kinase activity +is_a: GO:0061901 ! regulation of 1-phosphatidylinositol-3-kinase activity + +[Term] +id: GO:0061906 +name: autophagosome localization +namespace: biological_process +def: "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell." [PMID:26763909] +is_a: GO:1990849 ! vacuolar localization + +[Term] +id: GO:0061907 +name: negative regulation of AMPA receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity." [GOC:aruk, GOC:bc, PMID:20739563] +is_a: GO:1900450 ! negative regulation of glutamate receptor signaling pathway +is_a: GO:2000272 ! negative regulation of signaling receptor activity +is_a: GO:2000311 ! regulation of AMPA receptor activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:0061908 +name: phagophore +namespace: cellular_component +def: "A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle." [PMID:22664348, PMID:24201109] +synonym: "isolation membrane" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0061909 +name: autophagosome-lysosome fusion +namespace: biological_process +def: "The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome." [PMID:28077293] +synonym: "autophagosome fusion" BROAD [] +synonym: "autophagosome-vacuole fusion" EXACT [] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0061910 +name: autophagosome-endosome fusion +namespace: biological_process +def: "The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome." [PMID:24219988] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0061911 +name: amphisome-lysosome fusion +namespace: biological_process +def: "The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome." [PMID:24219988] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0061912 +name: selective autophagy +namespace: biological_process +def: "The macroautophagy process in which specific structures are targeted by the autophagy process." [PMID:20484971, PMID:21997368, PMID:22966490] +is_a: GO:0016236 ! macroautophagy + +[Term] +id: GO:0061913 +name: positive regulation of growth plate cartilage chondrocyte proliferation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869] +is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation +is_a: GO:0008284 ! positive regulation of cell population proliferation +relationship: positively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation + +[Term] +id: GO:0061914 +name: negative regulation of growth plate cartilage chondrocyte proliferation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [PMID:19264869] +is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0046621 ! negative regulation of organ growth +relationship: negatively_regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation + +[Term] +id: GO:0061915 +name: actin fusion focus localization +namespace: biological_process +def: "Any process in which an actin fusion focus are transported to, or maintained in, a specific location. The actin fusion focus is an aster-like, F-actin-containing structure at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion." [PMID:28410370] +synonym: "actin fusion focus localisation" EXACT [] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0061916 +name: leading edge of axonal growth cone +namespace: cellular_component +def: "That part of the axonal growth cone which represents the distal part of the structure." [PMID:16098134] +synonym: "axonal growth cone leading edge" EXACT [] +synonym: "distal tip of axonal growth cone" EXACT [] +is_a: GO:0061850 ! growth cone leading edge +relationship: part_of GO:0044295 ! axonal growth cone + +[Term] +id: GO:0061917 +name: leading edge of dendritic growth cone +namespace: cellular_component +def: "That part of the dendritic growth cone which represents the distal part of the structure." [PMID:16098134] +synonym: "dendritic growth cone leading edge" EXACT [] +synonym: "distal tip of dendritic growth cone" EXACT [] +is_a: GO:0061850 ! growth cone leading edge +relationship: part_of GO:0044294 ! dendritic growth cone + +[Term] +id: GO:0061919 +name: process utilizing autophagic mechanism +namespace: biological_process +def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] +subset: gocheck_do_not_annotate +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0061920 +name: protein propionyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide." [PMID:17267393] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0061921 +name: peptidyl-lysine propionylation +namespace: biological_process +def: "The propionylation of peptidyl-lysine." [PMID:17267393] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0061922 +name: histone propionyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone." [PMID:17267393] +is_a: GO:0061920 ! protein propionyltransferase activity + +[Term] +id: GO:0061923 +name: (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene." [PMID:27862766] +synonym: "protoillud-7-ene synthase activity" RELATED [] +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0061924 +name: regulation of formation of radial glial scaffolds +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441] +synonym: "regulation of Bergmann fiber biosynthesis" RELATED [] +synonym: "regulation of Bergmann fiber formation" RELATED [] +synonym: "regulation of radial glial scaffold formation" EXACT [] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +relationship: regulates GO:0021943 ! formation of radial glial scaffolds + +[Term] +id: GO:0061925 +name: negative regulation of formation of radial glial scaffolds +namespace: biological_process +def: "Any process that reduces the frequency, rate or extent of the formation of radial glial scaffolds. The scaffolds are used as a substrate for the radial migration of cells." [PMID:22076441] +synonym: "negative regulation of Bergmann fiber biosynthesis" RELATED [] +synonym: "negative regulation of Bergmann fiber formation" RELATED [] +synonym: "negative regulation of radial glial scaffold formation" EXACT [] +is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation +is_a: GO:0061924 ! regulation of formation of radial glial scaffolds +relationship: negatively_regulates GO:0021943 ! formation of radial glial scaffolds + +[Term] +id: GO:0061926 +name: positive regulation of formation of radial glial scaffolds +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the formation of radial glial cell scaffolds." [PMID:22076441] +synonym: "positive regulation of Bergmann fiber biosynthesis" RELATED [] +synonym: "positive regulation of Bergmann fiber formation" RELATED [] +synonym: "positive regulation of radial glial scaffold formation" EXACT [] +is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0061924 ! regulation of formation of radial glial scaffolds +relationship: positively_regulates GO:0021943 ! formation of radial glial scaffolds + +[Term] +id: GO:0061927 +name: TOC-TIC supercomplex I +namespace: cellular_component +def: "The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110." [PMID:28745032] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0061928 +name: glutathione specific gamma-glutamylcyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine." [PMID:23070364, PMID:27913623] +xref: EC:4.3.2.7 +xref: RHEA:47724 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0061929 +name: gamma-glutamylaminecyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline." [PMID:20110353, PMID:6107907] +xref: EC:4.3.2.8 +xref: RHEA:16961 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0061930 +name: regulation of erythrocyte enucleation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:1903429 ! regulation of cell maturation +relationship: regulates GO:0043131 ! erythrocyte enucleation + +[Term] +id: GO:0061931 +name: positive regulation of erythrocyte enucleation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0061930 ! regulation of erythrocyte enucleation +relationship: positively_regulates GO:0043131 ! erythrocyte enucleation + +[Term] +id: GO:0061932 +name: negative regulation of erythrocyte enucleation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of erythrocyte enucleation." [PMID:25241935] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0061930 ! regulation of erythrocyte enucleation +is_a: GO:1903430 ! negative regulation of cell maturation +relationship: negatively_regulates GO:0043131 ! erythrocyte enucleation + +[Term] +id: GO:0061934 +name: regulation of adenine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an adenine biosynthetic process." [PMID:19933844] +is_a: GO:0006141 ! regulation of purine nucleobase metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0046084 ! adenine biosynthetic process + +[Term] +id: GO:0061935 +name: fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes +namespace: biological_process +def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes." [GOC:dph] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0009677 ! double fertilization forming two zygotes + +[Term] +id: GO:0061936 +name: fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm +namespace: biological_process +def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm." [PMID:21123745] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045026 ! plasma membrane fusion +relationship: part_of GO:0009567 ! double fertilization forming a zygote and endosperm + +[Term] +id: GO:0061938 +name: protein localization to somatodendritic compartment +namespace: biological_process +def: "A process in which a protein is transported to or maintained in a location within the somatodendritic compartment." [PMID:18341993] +synonym: "somatodendritic protein localization" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0061939 +name: c-di-GMP signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal." [PMID:22864416, PMID:28057864] +synonym: "3',5'-cyclic di-GMP signaling" EXACT [] +synonym: "cyclic di-(3':5')-guanosine monophosphate signaling" EXACT [] +synonym: "cyclic di-GMP signaling" EXACT [] +synonym: "cyclic diguanylate signaling" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0061940 +name: regulation of c-di-GMP signaling +namespace: biological_process +def: "Any process that modulates the rate frequency or extent of c-di-GMP signaling." [PMID:22864416] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +relationship: regulates GO:0061939 ! c-di-GMP signaling + +[Term] +id: GO:0061941 +name: positive regulation of c-di-GMP signaling +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0061940 ! regulation of c-di-GMP signaling +relationship: positively_regulates GO:0061939 ! c-di-GMP signaling + +[Term] +id: GO:0061942 +name: negative regulation of c-di-GMP signaling +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of c-di-GMP signaling." [PMID:22864416] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0061940 ! regulation of c-di-GMP signaling +relationship: negatively_regulates GO:0061939 ! c-di-GMP signaling + +[Term] +id: GO:0061944 +name: negative regulation of protein K48-linked ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:BHF, GOC:rph, PMID:23460740] +is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination +is_a: GO:1902915 ! negative regulation of protein polyubiquitination +relationship: negatively_regulates GO:0070936 ! protein K48-linked ubiquitination + +[Term] +id: GO:0061945 +name: regulation of protein K48-linked ubiquitination +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of protein K-48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [PMID:23460740] +is_a: GO:1902914 ! regulation of protein polyubiquitination +relationship: regulates GO:0070936 ! protein K48-linked ubiquitination + +[Term] +id: GO:0061948 +name: premature acrosome loss +namespace: biological_process +def: "The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:19153666, PMID:21380641, PMID:26655718] +comment: If the release of the acrosome content when the sperm reaches to the zona pellucida, consider using acrosome reaction. +synonym: "spontaneous acrosome loss" EXACT [] +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0061949 +name: regulation of premature acrosome loss +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248] +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0061948 ! premature acrosome loss + +[Term] +id: GO:0061950 +name: negative regulation of premature acrosome loss +namespace: biological_process +def: "Any process that stops, prevents or reduces the discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents." [PMID:22228629, PMID:23430248] +synonym: "negative regulation of spontaneous acrosome loss" EXACT [] +is_a: GO:0061949 ! regulation of premature acrosome loss +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0061948 ! premature acrosome loss + +[Term] +id: GO:0061951 +name: establishment of protein localization to plasma membrane +namespace: biological_process +def: "The directed movement of a protein to a specific location in a plasma membrane." [GOC:dph, GOC:vw] +is_a: GO:0072659 ! protein localization to plasma membrane +is_a: GO:0090150 ! establishment of protein localization to membrane + +[Term] +id: GO:0061952 +name: midbody abscission +namespace: biological_process +def: "The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells." [PMID:12737809, PMID:29903934] +synonym: "cell separation during cytokinesis" EXACT [] +synonym: "cytokinetic abscission" EXACT [] +is_a: GO:0061024 ! membrane organization +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:0061953 +name: mRNA (adenine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA." [PMID:29072297] +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0061954 +name: positive regulation of actin filament polymerization involved in sperm capacitation +namespace: biological_process +def: "Any process that icreases the rate or extent of actin polymerization as part of sperm capacitation. This process prevents a spontaneous acrosome reaction." [PMID:15749953, PMID:25966627, PMID:26514336, PMID:27178669] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0030838 ! positive regulation of actin filament polymerization +relationship: part_of GO:0048240 ! sperm capacitation + +[Term] +id: GO:0061955 +name: positive regulation of actin filament depolymerization involved in acrosome reaction +namespace: biological_process +def: "Any process that increases the rate or exent of actin depolymerization as part of the acrosome reaction. This allows the acrosomal membrane and plasma membrane to fuse." [PMID:20937821] +is_a: GO:0022414 ! reproductive process +is_a: GO:0030836 ! positive regulation of actin filament depolymerization +relationship: part_of GO:0007340 ! acrosome reaction + +[Term] +id: GO:0061956 +name: penetration of cumulus oophorus +namespace: biological_process +def: "The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [PMID:21380641] +synonym: "penetration of cumulus cells layer" EXACT [] +synonym: "penetration of cumulus mass" EXACT [] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007338 ! single fertilization + +[Term] +id: GO:0061957 +name: NVT complex +namespace: cellular_component +def: "A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1." [PMID:26365378] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0061959 +name: response to (R)-carnitine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an (R)-carnitine stimulus." [PMID:28102299] +synonym: "response to L-carnitine" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0061960 +name: regulation of heme oxygenase activity +namespace: biological_process +def: "Any process that modulates the frequency, or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:0061961 +name: positive regulation of heme oxygenase activity +namespace: biological_process +def: "Any process that activates or increases the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:0061960 ! regulation of heme oxygenase activity + +[Term] +id: GO:0061962 +name: negative regulation of heme oxygenase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency or rate of heme oxygenase activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24844779] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:0061960 ! regulation of heme oxygenase activity + +[Term] +id: GO:0061963 +name: regulation of entry into reproductive diapause +namespace: biological_process +def: "Any process that modulates the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0055116 ! entry into reproductive diapause + +[Term] +id: GO:0061964 +name: negative regulation of entry into reproductive diapause +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0061963 ! regulation of entry into reproductive diapause +relationship: negatively_regulates GO:0055116 ! entry into reproductive diapause + +[Term] +id: GO:0061965 +name: positive regulation of entry into reproductive diapause +namespace: biological_process +def: "Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:ha, PMID:27689881] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0061963 ! regulation of entry into reproductive diapause +relationship: positively_regulates GO:0055116 ! entry into reproductive diapause + +[Term] +id: GO:0061966 +name: establishment of left/right asymmetry +namespace: biological_process +def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] +is_a: GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:0061967 +name: establishment of left sidedness +namespace: biological_process +def: "The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side." [GOC:18629866, GOC:BHF] +is_a: GO:0061966 ! establishment of left/right asymmetry + +[Term] +id: GO:0061968 +name: maintenance of left/right asymmetry +namespace: biological_process +def: "The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] +is_a: GO:0007389 ! pattern specification process + +[Term] +id: GO:0061969 +name: maintenance of left sidedness +namespace: biological_process +def: "The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] +is_a: GO:0061968 ! maintenance of left/right asymmetry + +[Term] +id: GO:0061970 +name: maintenance of right sidedness +namespace: biological_process +def: "The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, PMID:18629866] +is_a: GO:0061968 ! maintenance of left/right asymmetry + +[Term] +id: GO:0061971 +name: replacement bone morphogenesis +namespace: biological_process +def: "The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone." [DOI:10.1002/(SICI)1097-4687(199608)229\:2<121\:\:AID-JMOR1>3.0.CO;2-4] +is_a: GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0061972 +name: dermal bone morphogenesis +namespace: biological_process +def: "The process in which bone which forms superficially in the organism are generated and organized." [PMID:12588850, PMID:15003632] +is_a: GO:0061973 ! membrane bone morphogenesis + +[Term] +id: GO:0061973 +name: membrane bone morphogenesis +namespace: biological_process +def: "The process in which bone which forms deep in the organism are generated and organized." [PMID:14579374] +is_a: GO:0060349 ! bone morphogenesis + +[Term] +id: GO:0061974 +name: perichondral bone morphogenesis +namespace: biological_process +def: "The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone." [PMID:21901110] +is_a: GO:0060350 ! endochondral bone morphogenesis +is_a: GO:0061973 ! membrane bone morphogenesis + +[Term] +id: GO:0061975 +name: articular cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure." [PMID:20097540, PMID:20679519] +synonym: "articular cartilage of joint development" EXACT [] +is_a: GO:0051216 ! cartilage development + +[Term] +id: GO:0061976 +name: temporomandibular joint articular cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure." [PMID:20679519] +is_a: GO:0061975 ! articular cartilage development + +[Term] +id: GO:0061977 +name: hip joint articular cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure." [PMID:20097540] +is_a: GO:0061975 ! articular cartilage development + +[Term] +id: GO:0061978 +name: mandibular condyle articular cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure." [PMID:20679519] +is_a: GO:0061976 ! temporomandibular joint articular cartilage development + +[Term] +id: GO:0061979 +name: femoral head articular cartilage development +namespace: biological_process +def: "The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure." [PMID:20097540] +is_a: GO:0061977 ! hip joint articular cartilage development + +[Term] +id: GO:0061980 +name: regulatory RNA binding +namespace: molecular_function +def: "Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme." [PMID:14622403, PMID:23475961] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0061981 +name: 3-hydroxykynureninase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine." [PMID:17300176] +xref: RHEA:25143 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0061982 +name: meiosis I cell cycle process +namespace: biological_process +def: "A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs." [PMID:29385397] +synonym: "first meiotic cell division" EXACT [PMID:29385397] +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0061983 +name: meiosis II cell cycle process +namespace: biological_process +def: "A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes." [PMID:29385397] +synonym: "second meiotic division" EXACT [PMID:29385397] +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0061984 +name: catabolite repression +namespace: biological_process +def: "A process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources." [GOC:dph, PMID:29197127, PMID:29295552] +is_a: GO:0031670 ! cellular response to nutrient +relationship: negatively_regulates GO:0008152 ! metabolic process + +[Term] +id: GO:0061985 +name: carbon catabolite repression +namespace: biological_process +def: "A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources." [PMID:29295552] +is_a: GO:0061984 ! catabolite repression + +[Term] +id: GO:0061986 +name: negative regulation of transcription by glucose +namespace: biological_process +def: "Any process involving glucose that decreases the frequency, rate or extent or transcription." [PMID:11875061] +is_a: GO:0046015 ! regulation of transcription by glucose + +[Term] +id: GO:0061987 +name: negative regulation of transcription from RNA polymerase II promoter by glucose +namespace: biological_process +def: "Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter." [PMID:11875061] +is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose +is_a: GO:0061986 ! negative regulation of transcription by glucose + +[Term] +id: GO:0061988 +name: karyosome formation +namespace: biological_process +def: "The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0061982 ! meiosis I cell cycle process +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0007276 ! gamete generation + +[Term] +id: GO:0061989 +name: sperm karyosome formation +namespace: biological_process +def: "The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:19696886] +is_a: GO:0061988 ! karyosome formation +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:0061990 +name: beta-ketodecanoyl-[acyl-carrier-protein] synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2." [EC:2.3.1.207, PMID:22753057] +xref: MetaCyc:RXN-13613 +xref: RHEA:42264 +is_a: GO:0016415 ! octanoyltransferase activity + +[Term] +id: GO:0061992 +name: obsolete ATP-dependent chaperone mediated protein folding +namespace: biological_process +def: "OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and dependent on ATP hydrolysis." [PMID:18311152] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0006457 +consider: GO:0140662 + +[Term] +id: GO:0061993 +name: calcium:proton antiporter complex +namespace: cellular_component +def: "A protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [GOC:bhm, PMID:19098009, PMID:28645169] +synonym: "CAX1 homodimer" NARROW [GOC:bhm] +synonym: "CAX1-CAX3 complex" NARROW [GOC:bhm] +synonym: "CAX3 homodimer" NARROW [GOC:bhm] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:0061995 +name: ATP-dependent protein-DNA complex displacement activity +namespace: molecular_function +alt_id: GO:0061994 +def: "An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis." [PMID:18593879] +synonym: "ATP-dependent protein-nucleic acid complex displacement activity" NARROW [] +is_a: GO:0140083 ! ATP-dependent protein-DNA unloading activity + +[Term] +id: GO:0061999 +name: regulation of cardiac endothelial to mesenchymal transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0140074 ! cardiac endothelial to mesenchymal transition + +[Term] +id: GO:0062000 +name: positive regulation of cardiac endothelial to mesenchymal transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition +relationship: positively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition + +[Term] +id: GO:0062001 +name: negative regulation of cardiac endothelial to mesenchymal transition +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26857067] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0061999 ! regulation of cardiac endothelial to mesenchymal transition +relationship: negatively_regulates GO:0140074 ! cardiac endothelial to mesenchymal transition + +[Term] +id: GO:0062002 +name: regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +namespace: biological_process +def: "Any process that modulates the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0062003 +name: negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +namespace: biological_process +def: "Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0062002 ! regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +is_a: GO:0062014 ! negative regulation of small molecule metabolic process + +[Term] +id: GO:0062009 +name: secondary palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences." [PMID:28784960] +is_a: GO:0060021 ! roof of mouth development + +[Term] +id: GO:0062010 +name: primitive palate development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the primitive palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure." [GOC:dph] +is_a: GO:0060021 ! roof of mouth development + +[Term] +id: GO:0062011 +name: mitochondrial respiratory chain complex IV pre-assembly complex +namespace: cellular_component +def: "A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components." [GOC:lnp, PMID:21068384] +synonym: "COX pre-assemply complex" BROAD [GOC:lnp] +synonym: "COX1 preassemply complex" EXACT [GOC:lnp] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +is_a: GO:0101031 ! chaperone complex + +[Term] +id: GO:0062012 +name: regulation of small molecule metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a small molecule metabolic process." [GOC:vw] +synonym: "regulation of small molecule metabolism" EXACT [] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0062013 +name: positive regulation of small molecule metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] +synonym: "positive regulation of small molecule metabolism" EXACT [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: positively_regulates GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0062014 +name: negative regulation of small molecule metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process." [GOC:vw] +synonym: "negative regulation of small molecule metabolism" EXACT [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: negatively_regulates GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0062021 +name: mitotic cohesin dsDNA (leading strand) loading +namespace: biological_process +def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle." [GOC:vw, PMID:29358048] +is_a: GO:0061780 ! mitotic cohesin loading + +[Term] +id: GO:0062022 +name: mitotic cohesin ssDNA (lagging strand) loading +namespace: biological_process +def: "The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle." [GOC:vw, PMID:29358048] +synonym: "second-DNA capture" EXACT [GOC:vw] +is_a: GO:0061780 ! mitotic cohesin loading + +[Term] +id: GO:0062023 +name: collagen-containing extracellular matrix +namespace: cellular_component +def: "An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells." [GOC:BHF, GOC:rph, PMID:21123617] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0062025 +name: regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that modualtes the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +relationship: regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0062026 +name: negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process +namespace: biological_process +def: "Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] +is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +relationship: negatively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0062027 +name: positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process +namespace: biological_process +def: "Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:28007894] +is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:0062025 ! regulation of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process +relationship: positively_regulates GO:0031146 ! SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0062028 +name: regulation of stress granule assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of stress granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0034063 ! stress granule assembly + +[Term] +id: GO:0062029 +name: positive regulation of stress granule assembly +namespace: biological_process +def: "Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] +is_a: GO:0062028 ! regulation of stress granule assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0034063 ! stress granule assembly + +[Term] +id: GO:0062030 +name: negative regulation of stress granule assembly +namespace: biological_process +def: "Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [PMID:20180778] +is_a: GO:0062028 ! regulation of stress granule assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0034063 ! stress granule assembly + +[Term] +id: GO:0062031 +name: filamentous growth MAPK cascade +namespace: biological_process +def: "The MAPK cascade which is activated as a result of partial nutrient deprivation and which results in filamentous growth." [PMID:17604854] +is_a: GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:0062032 +name: cichorine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cichorine, a secondary metabolite found in some species of fungi." [PMID:24244835] +synonym: "cichorine anabolism" EXACT [] +synonym: "cichorine biosynthesis" EXACT [] +synonym: "cichorine formation" EXACT [] +synonym: "cichorine synthesis" EXACT [] +is_a: GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:0062033 +name: positive regulation of mitotic sister chromatid segregation +namespace: biological_process +def: "Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis." [PMID:12773390] +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +is_a: GO:0051984 ! positive regulation of chromosome segregation +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0000070 ! mitotic sister chromatid segregation + +[Term] +id: GO:0062034 +name: L-pipecolic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-pipecolic acid, a metabolite of lysine." [PMID:27758894, PMID:28330936] +synonym: "L-pipecolate biosynthetic process" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0062035 +name: sensory perception of cold stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241] +is_a: GO:0050955 ! thermoception + +[Term] +id: GO:0062036 +name: sensory perception of hot stimulus +namespace: biological_process +def: "The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal." [PMID:21335241] +is_a: GO:0050955 ! thermoception + +[Term] +id: GO:0062037 +name: D-loop DNA binding +namespace: molecular_function +def: "Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind." [PMID:20924116] +synonym: "DNA displacement loop binding" EXACT [] +is_a: GO:0000217 ! DNA secondary structure binding + +[Term] +id: GO:0062038 +name: positive regulation of pheromone response MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade." [PMID:9315645] +is_a: GO:0043410 ! positive regulation of MAPK cascade +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0071507 ! pheromone response MAPK cascade + +[Term] +id: GO:0062039 +name: biofilm matrix +namespace: cellular_component +def: "A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells." [GOC:BHF, PMID:22571672, PMID:27129222, PMID:28516088] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0062040 +name: fungal biofilm matrix +namespace: cellular_component +def: "An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses." [GOC:BHF, PMID:27129222, PMID:28516088] +is_a: GO:0062039 ! biofilm matrix + +[Term] +id: GO:0062041 +name: positive regulation of meiotic sister chromatid arm separation +namespace: biological_process +def: "Any process that increases the rate or exent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis." [PMID:20383139] +is_a: GO:1905134 ! positive regulation of meiotic chromosome separation +relationship: positively_regulates GO:0051755 ! meiotic sister chromatid arm separation + +[Term] +id: GO:0062042 +name: regulation of cardiac epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +relationship: regulates GO:0060317 ! cardiac epithelial to mesenchymal transition + +[Term] +id: GO:0062043 +name: positive regulation of cardiac epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that starts or increases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:rph, PMID:20951801] +is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition +is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition +relationship: positively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition + +[Term] +id: GO:0062044 +name: negative regulation of cardiac epithelial to mesenchymal transition +namespace: biological_process +def: "Any process that stops or decreases the rate, frequency or extent of cardiac epithelial to mesenchymal transition, a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BFH, GOC:rph, PMID:20951801] +is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition +is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition +relationship: negatively_regulates GO:0060317 ! cardiac epithelial to mesenchymal transition + +[Term] +id: GO:0062045 +name: L-lysine alpha-aminotransferase +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine." [PMID:27758894, PMID:28330936] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0062046 +name: dehydropipecolic acid reductase +namespace: molecular_function +def: "Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+." [PMID:27758894, PMID:28330936] +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0062047 +name: pipecolic acid N-hydroxylase +namespace: molecular_function +def: "Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O." [PMID:27758894, PMID:28330936] +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0062048 +name: lymphotoxin complex +namespace: cellular_component +def: "A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations." [PMID:1733951] +synonym: "lymphotoxin alpha-beta" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0062049 +name: protein phosphatase inhibitor complex +namespace: cellular_component +def: "A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase." [GOC:bhm, PMID:19407142, PMID:19933100] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0062050 +name: GPI-mannose ethanolamine phosphate phosphodiesterase activity +namespace: molecular_function +def: "A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor." [PMID:19837036] +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0062051 +name: lipopolysaccharide transport system +namespace: cellular_component +def: "A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner." [PMID:29449493] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:0062052 +name: starch granule initiation +namespace: biological_process +def: "The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts." [PMID:28684429] +is_a: GO:0019252 ! starch biosynthetic process + +[Term] +id: GO:0062054 +name: fluoride channel activity +namespace: molecular_function +def: "Enables the facilitated diffusion of fluoride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [PMID:23991286, PMID:25156118] +is_a: GO:0005253 ! anion channel activity +is_a: GO:1903425 ! fluoride transmembrane transporter activity + +[Term] +id: GO:0062055 +name: photosynthetic state transition +namespace: biological_process +def: "A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems." [PMID:29967049] +is_a: GO:0042548 ! regulation of photosynthesis, light reaction + +[Term] +id: GO:0062056 +name: compound eye pigment cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia." [GOC:ha, PMID:8929534] +is_a: GO:0050931 ! pigment cell differentiation +relationship: part_of GO:0001745 ! compound eye morphogenesis + +[Term] +id: GO:0062057 +name: L-aspartate:fumarate antiporter activity +namespace: molecular_function +def: "Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out)." [PMID:29995997] +is_a: GO:0015138 ! fumarate transmembrane transporter activity +is_a: GO:0015183 ! L-aspartate transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity + +[Term] +id: GO:0062058 +name: transcription factor TFIIH holo complex binding +namespace: molecular_function +def: "Binding to a transcription factor TFIIH holo complex." [PMID:11259578] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062059 +name: FACT complex binding +namespace: molecular_function +def: "Binding to a FACT complex." [PMID:10682845] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062060 +name: NuA4 histone acetyltransferase complex binding +namespace: molecular_function +def: "Binding to a NuA4 histone acetyltransferase complex." [PMID:15528408] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062061 +name: TAP complex binding +namespace: molecular_function +def: "Binding to a TAP complex." [PMID:17947644] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062062 +name: oligosaccharyltransferase complex binding +namespace: molecular_function +def: "Binding to an oligosaccharyltransferase complex." [PMID:12887896] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062063 +name: BBSome binding +namespace: molecular_function +def: "Binding to a BBSome complex." [PMID:20603001] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062064 +name: box C/D snoRNP complex binding +namespace: molecular_function +def: "Binding to a box C/D snoRNP complex." [PMID:10679015] +is_a: GO:0030519 ! snoRNP binding + +[Term] +id: GO:0062065 +name: box H/ACA snoRNP complex binding +namespace: molecular_function +def: "Binding to a box H/ACA snoRNP complex." [PMID:10679015] +is_a: GO:0030519 ! snoRNP binding + +[Term] +id: GO:0062066 +name: PSII associated light-harvesting complex II binding +namespace: molecular_function +def: "Binding to a PSII associated light-harvesting complex II." [PMID:17400553] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062067 +name: chloroplast photosystem I binding +namespace: molecular_function +def: "Binding to a chloroplast photosystem I." [PMID:17400553] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062068 +name: chloroplast photosystem II binding +namespace: molecular_function +def: "Binding to a chloroplast photosystem II." [PMID:17400553] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062069 +name: GARP complex binding +namespace: molecular_function +def: "Binding to a GARP complex." [PMID:20163565] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062070 +name: SAGA complex binding +namespace: molecular_function +def: "Binding to a SAGA complex." [PMID:27185460] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062071 +name: Pi Mi complex +namespace: cellular_component +def: "A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis." [PMID:30089908] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0062072 +name: H3K9me3 modified histone binding +namespace: molecular_function +def: "Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation." [PMID:30110338] +is_a: GO:0035064 ! methylated histone binding + +[Term] +id: GO:0062073 +name: histone mRNA stem-loop binding complex +namespace: cellular_component +def: "A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export." [GOC:bhm, PMID:18025107, PMID:23286197] +synonym: "SLBP-MIF4GD complex" NARROW [] +synonym: "SLBP-SLIP1 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0062074 +name: pollen aperture +namespace: cellular_component +def: "An area where exine is reduced or absent, in the pollen wall." [PMID:30150313] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043667 ! pollen wall + +[Term] +id: GO:0062075 +name: pollen aperture formation +namespace: biological_process +def: "The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall." [PMID:30150313] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +relationship: part_of GO:0010208 ! pollen wall assembly + +[Term] +id: GO:0062076 +name: acyl-CoA delta5-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O." [PMID:10601301, PMID:10769175, RHEA:46424] +synonym: "acyl-CoA (8-3)-desaturase" EXACT [] +synonym: "acyl-CoA D5-desaturase activity" EXACT [] +synonym: "acyl-CoA delta(5)-desaturase activity" EXACT [] +xref: EC:1.14.19.44 +xref: RHEA:46424 +is_a: GO:0016215 ! acyl-CoA desaturase activity + +[Term] +id: GO:0062077 +name: phenylacetyl-CoA 1,2-epoxidase complex +namespace: cellular_component +def: "A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)." [GOC:bhm, PMID:21247899] +synonym: "paaABCE complex" NARROW [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0062078 +name: TSC1-TSC2 complex binding +namespace: molecular_function +def: "Binding to a TSC1-TSC2 complex." [PMID:28561066] +synonym: "tuberin sclerosis complex binding" EXACT [] +synonym: "tuberin-hamartin complex binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0062079 +name: ATG2-ATG18 complex +namespace: cellular_component +def: "A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae." [GOC:bhm, PMID:23230146] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0034045 ! phagophore assembly site membrane + +[Term] +id: GO:0062080 +name: inhibitory MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] +is_a: GO:0032394 ! MHC class Ib receptor activity + +[Term] +id: GO:0062081 +name: activating MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte." [DOI:10.1002/9780470015902.a0024246] +is_a: GO:0032394 ! MHC class Ib receptor activity + +[Term] +id: GO:0062082 +name: HLA-E specific inhibitory MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] +is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity + +[Term] +id: GO:0062083 +name: HLA-G specific inhibitory MHC class Ib receptor activity +namespace: molecular_function +def: "Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte." [DOI:10.1002/9780470015902.a0024246] +is_a: GO:0062080 ! inhibitory MHC class Ib receptor activity + +[Term] +id: GO:0062084 +name: regulation of capsule polysaccharide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:1901913 ! regulation of capsule organization +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0045227 ! capsule polysaccharide biosynthetic process + +[Term] +id: GO:0062085 +name: positive regulation of capsule polysaccharide biosynthetic process +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [PMID:21917918] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062084 ! regulation of capsule polysaccharide biosynthetic process +is_a: GO:1901915 ! positive regulation of capsule organization +relationship: positively_regulates GO:0045227 ! capsule polysaccharide biosynthetic process + +[Term] +id: GO:0062086 +name: regulation of vein smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction +relationship: regulates GO:0014826 ! vein smooth muscle contraction + +[Term] +id: GO:0062087 +name: positive regulation of vein smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] +is_a: GO:0062086 ! regulation of vein smooth muscle contraction +is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction +relationship: positively_regulates GO:0014826 ! vein smooth muscle contraction + +[Term] +id: GO:0062088 +name: negative regulation of vein smooth muscle contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of vein smooth muscle contraction." [PMID:8428203] +is_a: GO:0062086 ! regulation of vein smooth muscle contraction +is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction +relationship: negatively_regulates GO:0014826 ! vein smooth muscle contraction + +[Term] +id: GO:0062089 +name: regulation of taurine biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0042412 ! taurine biosynthetic process + +[Term] +id: GO:0062090 +name: positive regulation of taurine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of taurine biosynthesis." [GOC:BHF, PMID:18648510, PMID:24911144] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:0062089 ! regulation of taurine biosynthetic process +relationship: positively_regulates GO:0042412 ! taurine biosynthetic process + +[Term] +id: GO:0062091 +name: Ycf2/FtsHi complex +namespace: cellular_component +def: "A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma." [PMID:30309901] +synonym: "TIC complex associated chloroplast protein import motor" EXACT [] +is_a: GO:1904949 ! ATPase complex + +[Term] +id: GO:0062092 +name: Yae1-Lto1 complex +namespace: cellular_component +def: "A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p." [PMID:26182403] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0062093 +name: lysophagy +namespace: biological_process +def: "The selective autophagy process in which a damaged lysosome is degraded by macroautophagy." [PMID:28743755] +is_a: GO:0061912 ! selective autophagy + +[Term] +id: GO:0062094 +name: stomach development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ." [PMID:11967278] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0062095 +name: endoplasmic reticulum-peroxisome tethering +namespace: biological_process +def: "The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:28463579] +is_a: GO:0060151 ! peroxisome localization +is_a: GO:0140056 ! organelle localization by membrane tethering + +[Term] +id: GO:0062096 +name: kinetochore disassembly +namespace: biological_process +def: "The disaggregation of a kinetochore into its constituent components." [GOC:mah, PMID:27611693] +is_a: GO:0051383 ! kinetochore organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:0062097 +name: chemosynthesis +namespace: biological_process +def: "The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane." [PMID:25050523] +xref: Wikipedia:Chemosynthesis +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0062098 +name: regulation of programmed necrotic cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] +is_a: GO:0010939 ! regulation of necrotic cell death +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:0062099 +name: negative regulation of programmed necrotic cell death +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0060547 ! negative regulation of necrotic cell death +is_a: GO:0062098 ! regulation of programmed necrotic cell death +relationship: negatively_regulates GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:0062100 +name: positive regulation of programmed necrotic cell death +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of programmed necrotic cell death." [GOC:aruk, GOC:rph, PMID:27258785] +is_a: GO:0010940 ! positive regulation of necrotic cell death +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:0062098 ! regulation of programmed necrotic cell death +relationship: positively_regulates GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:0062101 +name: peptidyl-aspartic acid 3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0004597 +def: "Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2." [PMID:1378441, PMID:1856229, RHEA:11508] +synonym: "aspartate beta-hydroxylase activity" RELATED [EC:1.14.11.16] +synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] +synonym: "aspartylpeptide beta-dioxygenase activity" RELATED [EC:1.14.11.16] +synonym: "peptide-aspartate beta-dioxygenase activity" EXACT [] +synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" RELATED [EC:1.14.11.16] +xref: EC:1.14.11.16 +xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN +xref: RHEA:11508 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0062102 +name: female germline stem cell symmetric division +namespace: biological_process +def: "Division of a female germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:ha, PMID:30248087] +is_a: GO:0098729 ! germline stem cell symmetric division + +[Term] +id: GO:0062103 +name: double-stranded RNA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of double-stranded RNA." [PMID:19701182] +synonym: "double-stranded RNA biosynthesis" EXACT [] +synonym: "dsRNA biosynthesis" EXACT [] +synonym: "dsRNA biosynthetic process" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:rl] +is_a: GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:0062104 +name: pumilio-response element binding +namespace: molecular_function +def: "Binding to a region of RNA containing a Pumilio-response element element. The consensus sequence for the element is UGUAAAUA." [PMID:30601114] +synonym: "PRE binding" EXACT [PMID:30601114] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0062105 +name: RNA 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide." [PMID:30626973, RHEA:58956] +xref: RHEA:58956 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008173 ! RNA methyltransferase activity + +[Term] +id: GO:0062107 +name: regulation of protein localization to non-growing cell tip +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707] +is_a: GO:1903066 ! regulation of protein localization to cell tip +relationship: regulates GO:1902487 ! protein localization to non-growing cell tip + +[Term] +id: GO:0062108 +name: negative regulation of protein localization to non-growing cell tip +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip." [PMID:18328707] +is_a: GO:0062107 ! regulation of protein localization to non-growing cell tip +is_a: GO:1903067 ! negative regulation of protein localization to cell tip +relationship: negatively_regulates GO:1902487 ! protein localization to non-growing cell tip + +[Term] +id: GO:0062109 +name: regulation of DNA recombinase disassembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of DNA recombinase disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +relationship: regulates GO:1990986 ! DNA recombinase disassembly + +[Term] +id: GO:0062110 +name: negative regulation of DNA recombinase disassembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components." [PMID:30297419] +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +is_a: GO:0062109 ! regulation of DNA recombinase disassembly +relationship: negatively_regulates GO:1990986 ! DNA recombinase disassembly + +[Term] +id: GO:0062111 +name: zinc ion import into organelle +namespace: biological_process +def: "The directed import of zinc(2+) from the cytosol, across an organelle membrane, into the organelle." [PMID:29529046] +is_a: GO:0071577 ! zinc ion transmembrane transport + +[Term] +id: GO:0062112 +name: fatty acid primary amide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a fatty acid primary amide." [PMID:10079066, PMID:15952893] +synonym: "FAPA biosynthesis" EXACT [] +synonym: "FAPA biosynthetic process" EXACT [] +synonym: "fatty acid amide biosynthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0062126 ! fatty acid primary amide metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process + +[Term] +id: GO:0062113 +name: early phagosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an eary phagosome." [PMID:18813294] +synonym: "early phagocytic vesicle lumen" EXACT [] +is_a: GO:0097013 ! phagocytic vesicle lumen +relationship: part_of GO:0032009 ! early phagosome + +[Term] +id: GO:0062116 +name: phenyloplast +namespace: cellular_component +def: "A chloroplast-derived plastid in which the solid form of phenol is stored." [PMID:24683183] +is_a: GO:0009536 ! plastid + +[Term] +id: GO:0062119 +name: LinE complex +namespace: cellular_component +def: "A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0062120 +name: LinE complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins." [PMID:30640914] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0030999 ! linear element assembly + +[Term] +id: GO:0062121 +name: linear element maturation +namespace: biological_process +def: "The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements." [PMID:30640914] +synonym: "LinE chromosome loading" EXACT [GOC:mah] +synonym: "LinE focus formation" EXACT [GOC:mah] +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +relationship: part_of GO:0030999 ! linear element assembly + +[Term] +id: GO:0062122 +name: histone methyltransferase activity (H3-K37 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group onto lysine at position 37 of the histone H3 protein." [PMID:30773398] +synonym: "histone lysine N-methyltransferase activity (H3-K37 specific)" EXACT [] +is_a: GO:0018024 ! histone-lysine N-methyltransferase activity + +[Term] +id: GO:0062123 +name: regulation of linear element maturation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of linear element maturation." [PMID:30640914] +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0090006 ! regulation of linear element assembly +relationship: regulates GO:0062121 ! linear element maturation + +[Term] +id: GO:0062124 +name: 4-hydroxybutyrate receptor activity +namespace: molecular_function +def: "Combining with 4-hydroxybutyrte to initiate a change in cell activity." [PMID:17197387] +synonym: "gamma-hydroxybutyrate receptor activity" EXACT [PMID:17197387] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0062125 +name: regulation of mitochondrial gene expression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [PMID:28285835] +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0140053 ! mitochondrial gene expression + +[Term] +id: GO:0062126 +name: fatty acid primary amide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform primary fatty amides." [PMID:11128635] +synonym: "primary fatty amide metabolic process" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:0062127 +name: fatty acid primary amide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of primary fatty amides." [PMID:11128635] +synonym: "primary fatty amide catabolic process" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0062126 ! fatty acid primary amide metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901569 ! fatty acid derivative catabolic process + +[Term] +id: GO:0062128 +name: MutSgamma complex +namespace: cellular_component +def: "A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5." [PMID:27648641, PMID:7622037, PMID:8001134, PMID:9374523] +synonym: "Msh4-Msh5 complex" NARROW [] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0062129 +name: chitin-based extracellular matrix +namespace: cellular_component +def: "Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet." [PMID:23955854] +synonym: "chitin-based ECM" EXACT [GOC:dph] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0062130 +name: adhesive extracellular matrix +namespace: cellular_component +def: "A extracellular matrix which attaches an organism to a substrate." [GOC:dph, GOC:ha, PMID:825230] +synonym: "puparial glue" NARROW [GOC:ha] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0062131 +name: 3-butenylglucosinolate 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O." [PMID:18945935] +synonym: "But-3-enyl Glucosinolate-2-hydroxylase activity" EXACT [] +xref: MetaCyc:RXNQT-4343 +xref: RHEA:60628 +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0062132 +name: regulation of L-glutamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] +is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:1901704 ! L-glutamine biosynthetic process + +[Term] +id: GO:0062133 +name: negative regulation of L-glutamine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] +is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:1901704 ! L-glutamine biosynthetic process + +[Term] +id: GO:0062134 +name: positive regulation of L-glutamine biosynthetic process +namespace: biological_process +def: "Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis." [GOC:ha, PMID:19755423] +is_a: GO:0062132 ! regulation of L-glutamine biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:1901704 ! L-glutamine biosynthetic process + +[Term] +id: GO:0062136 +name: low-density lipoprotein receptor complex +namespace: cellular_component +def: "A plasma membrane protein complex capable of low-density lipoprotein particle receptor activity. It may also bind xenobiotic toxins and deliver them into the cell via endocytosis. While most substrates get degraded via the endosome the receptor is recycled to the plasma membrane. It may also act as a transducer of intracellular signal pathways and often acts in corporation with other cell-surface receptors." [GOC:bhm, PMID:26005850] +synonym: "LDL receptor complex" EXACT [GOC:dph] +synonym: "LDLR complex" EXACT [GOC:dph] +synonym: "low-density lipoprotein particle receptor complex" EXACT [GOC:dph] +is_a: GO:0062137 ! cargo receptor complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0062137 +name: cargo receptor complex +namespace: cellular_component +def: "Any protein complex that is part of a membrane and which functions as a cargo receptor." [PMID:27903609] +is_a: GO:0098796 ! membrane protein complex + +[Term] +id: GO:0062139 +name: camera-type eye photoreceptor cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure." [PMID:20648062, PMID:30237290] +is_a: GO:0042462 ! eye photoreceptor cell development +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:0062140 +name: hyphae septin collar +namespace: cellular_component +def: "A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell." [PMID:29567712] +synonym: "septin collar of invasive hyphae" RELATED [] +is_a: GO:0032173 ! septin collar + +[Term] +id: GO:0062141 +name: nuclear exosome targeting complex +namespace: cellular_component +def: "A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts." [PMID:21855801, PMID:29844170] +synonym: "NEXT complex" EXACT [PMID:21855801, PMID:29844170] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0062142 +name: L-beta-ethynylserine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria." [PMID:3082841, PMID:30867596] +is_a: GO:0120237 ! terminal acetylenic compound biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0062143 +name: L-propargylglycine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria." [PMID:30867596] +is_a: GO:0120237 ! terminal acetylenic compound biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0062144 +name: L-propargylglycine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine." [PMID:30867596, RHEA:59892] +xref: RHEA:59892 +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0062145 +name: L-propargylglycine--L-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate." [PMID:30867596, RHEA:59896] +xref: RHEA:59896 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0062146 +name: 4-chloro-allylglycine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+)." [PMID:30867596, RHEA:59888] +xref: RHEA:59888 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0062147 +name: L-lysine 4-chlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate." [PMID:30867596, RHEA:59884] +xref: RHEA:59884 +is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated + +[Term] +id: GO:0062148 +name: L-gamma-glutamyl-L-propargylglycine hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate." [PMID:30867596, RHEA:59900] +xref: RHEA:59900 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0062149 +name: detection of stimulus involved in sensory perception of pain +namespace: biological_process +def: "The series of events involved in the perception of pain in which a stimulus is received and converted into a molecular signal." [PMID:19837031] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +relationship: part_of GO:0019233 ! sensory perception of pain + +[Term] +id: GO:0062150 +name: amorpha-4,11-diene 12-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:16458889, PMID:16612385, PMID:23246612, RHEA:32999] +xref: EC:1.14.14.114 +xref: RHEA:32999 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0062151 +name: catalase complex +namespace: cellular_component +def: "A protein-containing complex that is capable of catalase activity." [GOC:bhm, PMID:10656833] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0062152 +name: mRNA (cytidine-5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine." [PMID:22395603, PMID:23871666, RHEA:61464] +synonym: "mRNA (cytosine-5-)-methyltransferase activity" EXACT [] +xref: RHEA:61464 +is_a: GO:0008174 ! mRNA methyltransferase activity + +[Term] +id: GO:0062153 +name: C5-methylcytidine-containing RNA binding +namespace: molecular_function +def: "Binding to an RNA molecule modified by C5-methylcytidine." [PMID:28418038] +synonym: "C5-methylcytosine-containing RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0062154 +name: N6-mAMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H(+) + H2O + N6-methyl-AMP = IMP + methylamine." [PMID:29884623, RHEA:16001] +synonym: "MAPDA" EXACT [PMID:29884623] +xref: RHEA:16001 +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0062155 +name: curli secretion complex +namespace: cellular_component +def: "A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms." [PMID:25219853] +is_a: GO:1902495 ! transmembrane transporter complex +relationship: part_of GO:0009279 ! cell outer membrane + +[Term] +id: GO:0062156 +name: mitochondrial ATP-gated potassium channel activity +namespace: molecular_function +def: "Enables the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016] +synonym: "mitochondrial potassium channel activity" EXACT [] +synonym: "mitoK-ATP activity" EXACT [] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0035381 ! ATP-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0062157 +name: mitochondrial ATP-gated potassium channel complex +namespace: cellular_component +def: "A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane." [PMID:31435016] +is_a: GO:0034705 ! potassium channel complex + +[Term] +id: GO:0062158 +name: chloride:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out)." [PMID:14985752] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity + +[Term] +id: GO:0062159 +name: contractile vacuole complex +namespace: cellular_component +def: "A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory." [PMID:23890380] +synonym: "CVC" RELATED [PMID:23890380] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0062160 +name: spongiome +namespace: cellular_component +def: "A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory." [PMID:23890380] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0062159 ! contractile vacuole complex + +[Term] +id: GO:0062161 +name: regulation of pyocyanine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477] +synonym: "regulation of pyocyanin biosynthetic process" EXACT [] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0106220 ! pyocyanine biosynthetic process + +[Term] +id: GO:0062162 +name: positive regulation of pyocyanine biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of a pyocyanine biosynthetic process." [PMID:28715477] +synonym: "positive regulation of pyocyanin biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0062161 ! regulation of pyocyanine biosynthetic process +relationship: positively_regulates GO:0106220 ! pyocyanine biosynthetic process + +[Term] +id: GO:0062163 +name: pseudohyphal septin ring assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of septins and associated proteins to form a tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection." [PMID:29567712] +is_a: GO:0000921 ! septin ring assembly + +[Term] +id: GO:0062164 +name: regulation of pseudohyphal septin ring assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0051493 ! regulation of cytoskeleton organization +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0062163 ! pseudohyphal septin ring assembly + +[Term] +id: GO:0062165 +name: positive regulation of pseudohyphal septin ring assembly +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation." [PMID:29567712] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0062163 ! pseudohyphal septin ring assembly + +[Term] +id: GO:0062166 +name: negative regulation of pseudohyphal septin ring assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly." [PMID:29567712] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0062164 ! regulation of pseudohyphal septin ring assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0062163 ! pseudohyphal septin ring assembly + +[Term] +id: GO:0062167 +name: complement component C1q complex +namespace: cellular_component +def: "A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning." [PMID:29449492] +synonym: "C1q" EXACT [] +synonym: "Complement 1q" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0062168 +name: negative regulation of plus-end directed microtubule sliding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183] +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0062169 ! regulation of plus-end directed microtubule sliding +relationship: negatively_regulates GO:0031535 ! plus-end directed microtubule sliding + +[Term] +id: GO:0062169 +name: regulation of plus-end directed microtubule sliding +namespace: biological_process +def: "Any process that mediates the frequency, rate, or extent of plus-end directed microtubule sliding." [PMID:21892183] +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0031535 ! plus-end directed microtubule sliding + +[Term] +id: GO:0062170 +name: lutein metabolic process +namespace: biological_process +def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform lutein." [PMID:24397433] +synonym: "lutein metabolism" EXACT [] +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:0062171 +name: lutein biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lutein." [PMID:24397433] +synonym: "lutein anabolism" EXACT [] +synonym: "lutein biosynthesis" EXACT [] +synonym: "lutein formation" EXACT [] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:0062170 ! lutein metabolic process + +[Term] +id: GO:0062172 +name: lutein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lutein." [PMID:24397433] +synonym: "lutein breakdown" EXACT [] +synonym: "lutein catabolism" EXACT [] +synonym: "lutein degradation" EXACT [] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:0062170 ! lutein metabolic process + +[Term] +id: GO:0062173 +name: brexanolone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways by which living organisms transform brexanolone." [PMID:24390875] +synonym: "allopregnanolone metabolic process" EXACT [] +synonym: "allopregnanolone metabolism" EXACT [] +synonym: "allotetrahydroprogesterone metabolic process" EXACT [] +synonym: "allotetrahydroprogesterone metabolism" EXACT [] +synonym: "brexanolone metabolism" EXACT [] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:0062174 +name: brexanolone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of brexanolone." [PMID:24390875] +synonym: "allopregnanolone anabolism" EXACT [] +synonym: "allopregnanolone biosynthesis" EXACT [] +synonym: "allopregnanolone biosynthetic process" EXACT [] +synonym: "allopregnanolone synthesis" EXACT [] +synonym: "allotetrahydroprogesterone anabolism" EXACT [] +synonym: "allotetrahydroprogesterone biosynthesis" EXACT [] +synonym: "allotetrahydroprogesterone biosynthetic process" EXACT [] +synonym: "allotetrahydroprogesterone synthesis" EXACT [] +synonym: "brexanolone anabolism" EXACT [] +synonym: "brexanolone biosynthesis" EXACT [] +synonym: "brexanolone synthesis" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0062173 ! brexanolone metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0062175 +name: brexanolone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of brexanolone." [PMID:24390875] +synonym: "allopregnanolone breakdown" EXACT [] +synonym: "allopregnanolone catabolic process" EXACT [] +synonym: "allopregnanolone catabolism" EXACT [] +synonym: "allopregnanolone degradation" EXACT [] +synonym: "allotetrahydroprogesterone breakdown" EXACT [] +synonym: "allotetrahydroprogesterone catabolic process" EXACT [] +synonym: "allotetrahydroprogesterone catabolism" EXACT [] +synonym: "allotetrahydroprogesterone degradation" EXACT [] +synonym: "brexanolone breakdown" EXACT [] +synonym: "brexanolone catabolism" EXACT [] +synonym: "brexanolone degradation" EXACT [] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0062173 ! brexanolone metabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:0062176 +name: R-loop disassembly +namespace: biological_process +def: "A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability." [PMID:28790157] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0062177 +name: radial spoke assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules." [PMID:21613541, PMID:21692193, PMID:24124175, PMID:27940518, PMID:8408197] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0035082 ! axoneme assembly + +[Term] +id: GO:0062179 +name: vitamin D 23-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-23 of any form of vitamin D." [PMID:22100522, PMID:30205156] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0062180 +name: 25-hydroxycholecalciferol-23-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:46616] +xref: RHEA:46616 +is_a: GO:0062179 ! vitamin D 23-hydroxylase activity + +[Term] +id: GO:0062181 +name: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity +namespace: molecular_function +def: "Catatlysis of the reaction: calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]." [PMID:22100522, PMID:30205156, RHEA:49192] +xref: RHEA:49192 +is_a: GO:0062179 ! vitamin D 23-hydroxylase activity + +[Term] +id: GO:0062182 +name: all-trans retinoic acid 4-hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:9250660, PMID:9716180, RHEA:51492] +xref: RHEA:51492 +is_a: GO:0008401 ! retinoic acid 4-hydroxylase activity + +[Term] +id: GO:0062183 +name: all-trans retinoic acid 18-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:22020119, RHEA:55856] +xref: RHEA:55856 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0062184 +name: testosterone 16-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:46304] +xref: RHEA:46304 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0062185 +name: secalciferol 1-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction:2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]." [PMID:10518789, RHEA:49064] +xref: RHEA:49064 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0062186 +name: anandamide epoxidase activity +namespace: molecular_function +def: "Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide." [PMID:21289075] +synonym: "arachidonoylethanolamide epoxidase activity" EXACT [PMID:21289075] +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0062187 +name: anandamide 8,9 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53140] +xref: RHEA:53140 +is_a: GO:0062186 ! anandamide epoxidase activity + +[Term] +id: GO:0062188 +name: anandamide 11,12 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53144] +xref: RHEA:53144 +is_a: GO:0062186 ! anandamide epoxidase activity + +[Term] +id: GO:0062189 +name: anandamide 14,15 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]." [PMID:21289075, RHEA:53148] +xref: RHEA:53148 +is_a: GO:0062186 ! anandamide epoxidase activity + +[Term] +id: GO:0062191 +name: galactoxylomannan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals." [PMID:16441437, PMID:18952901, PMID:19684080, PMID:21843086] +synonym: "galactoxylomannan anabolism" EXACT [] +synonym: "galactoxylomannan biosynthesis" EXACT [] +synonym: "galactoxylomannan formation" EXACT [] +synonym: "galactoxylomannan synthesis" EXACT [] +synonym: "GalXM biosynthetic process" EXACT [] +synonym: "glucuronoxylomannogalactan biosynthetic process" EXACT [] +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0062192 +name: L-rhamnose mutarotase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose." [RHEA:25584] +xref: EC:5.1.3.32 +xref: RHEA:25584 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0062193 +name: D-ribose pyranase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose." [RHEA:25432] +xref: EC:5.4.99.62 +xref: RHEA:25432 +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0062194 +name: cytoplasmic microtubule minus-end +namespace: cellular_component +def: "A microtubule minus end that is part of a cytoplasmic microtubule." [PMID:18061564] +is_a: GO:0036449 ! microtubule minus-end +relationship: part_of GO:0005881 ! cytoplasmic microtubule + +[Term] +id: GO:0062195 +name: microtubule bundle maintenance +namespace: biological_process +def: "The organization process that preserves a microtubule bundle in a stable functional or structural state." [PMID:18061564] +is_a: GO:0043954 ! cellular component maintenance + +[Term] +id: GO:0062196 +name: regulation of lysosome size +namespace: biological_process +def: "Any process that modulates the size of a lysosome." [PMID:31314175] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0062197 +name: cellular response to chemical stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress." [PMID:26653712] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0062198 +name: obsolete rDNA replication pause site heterochromatin +namespace: cellular_component +def: "OBSOLETE. A region of heterochromatin associated with sites in rDNA repeats where replication forks pause." [PMID:25417108] +comment: This term was obsoleted because it does not represent a specific cellular component. +is_obsolete: true + +[Term] +id: GO:0062199 +name: chromosome, centromeric inner repeat region +namespace: cellular_component +def: "The portion of the centromeric region of a chromosome that contains the inner inverted repeat region of a modular centromere and part of the central core surrounding a non-conserved central region. This region is adjacent to the central core, on each chromosome arm." [PMID:21437270] +synonym: "chromosome, centric outer repeat region" RELATED [] +is_a: GO:0098687 ! chromosomal region +relationship: part_of GO:0000775 ! chromosome, centromeric region + +[Term] +id: GO:0062200 +name: RAM/MOR signaling pathway +namespace: biological_process +def: "An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase." [PMID:15731009, PMID:16096637, PMID:20805322, PMID:20826805, PMID:21246752, PMID:22629372] +synonym: "MOR signaling pathway" NARROW [] +synonym: "morphogenesis Orb6 network" EXACT [] +synonym: "RAM signaling pathway" NARROW [] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0062201 +name: actin wave +namespace: cellular_component +def: "A cellular anatomical entity that is part of the actin cytoskeleton and results in a wave-like propagation of actin networks. It consists of dynamic structures traveling on the ventral (substrate-attached) side of the cell during cell migration, cytokinesis, adhesion and neurogenesis." [PMID:26190109, PMID:31230946, PMID:31390543, PMID:31678045, PMID:31774725] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0062202 +name: Labd-13(16),14-diene-9-ol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol." [PMID:29315936, RHEA:62184] +xref: RHEA:62184 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0062203 +name: Viteagnusin D synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D." [PMID:29315936, RHEA:62180] +xref: RHEA:62180 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0062204 +name: (13S)-vitexifolin A synthase activity +namespace: molecular_function +def: "Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate." [PMID:29315936, RHEA:40027] +xref: RHEA:40027 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0062205 +name: miltiradiene synthase activity +namespace: molecular_function +alt_id: GO:0102353 +def: "Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene." [PMID:24990389, RHEA:33983] +synonym: "multiradiene synthase activity" RELATED [] +xref: EC:4.2.3.131 +xref: MetaCyc:RXN-13338 +xref: RHEA:33983 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0062206 +name: manoyl oxide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate." [PMID:24990389, RHEA:54516] +xref: EC:4.2.3.190 +xref: RHEA:54516 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0062207 +name: regulation of pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0062208 +name: positive regulation of pattern recognition receptor signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of a pattern recognition receptor signaling pathway." [PMID:30610168] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway +relationship: positively_regulates GO:0002221 ! pattern recognition receptor signaling pathway + +[Term] +id: GO:0062209 +name: spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination." [PMID:25324213, PMID:30217891] +synonym: "crossover interference" RELATED [PMID:30217891] +synonym: "DSB interference" RELATED [] +synonym: "regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [] +synonym: "regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination" EXACT [] +is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + +[Term] +id: GO:0062210 +name: shoot regeneration +namespace: biological_process +def: "The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot." [PMID:27143753] +synonym: "shoot system regeneration" EXACT [] +is_a: GO:0031099 ! regeneration +is_a: GO:0048367 ! shoot system development + +[Term] +id: GO:0062211 +name: root regeneration +namespace: biological_process +def: "The the regeneration process by which a damaged or lost root regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to form a new root meristem and subsequently new root." [PMID:27143753] +is_a: GO:0031099 ! regeneration +is_a: GO:0048364 ! root development + +[Term] +id: GO:0062212 +name: regulation of mitotic DNA replication initiation from early origin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of firing from an early origin of replication involved in mitotic DNA replication." [PMID:22279046] +synonym: "regulation of early replication origin firing" EXACT [] +is_a: GO:1903466 ! regulation of mitotic DNA replication initiation + +[Term] +id: GO:0062213 +name: peroxynitrite isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: peroxynitrite = nitrate." [PMID:30524950, RHEA:63116] +xref: RHEA:63116 +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0062223 +name: regulation of somatic muscle development +namespace: biological_process +def: "Any process that regulates the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0007525 ! somatic muscle development + +[Term] +id: GO:0062224 +name: positive regulation of somatic muscle development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0062223 ! regulation of somatic muscle development +relationship: positively_regulates GO:0007525 ! somatic muscle development + +[Term] +id: GO:0062225 +name: negative regulation of somatic muscle development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0062223 ! regulation of somatic muscle development +relationship: negatively_regulates GO:0007525 ! somatic muscle development + +[Term] +id: GO:0062226 +name: regulation of adult somatic muscle development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062223 ! regulation of somatic muscle development +relationship: regulates GO:0007527 ! adult somatic muscle development + +[Term] +id: GO:0062227 +name: positive regulation of adult somatic muscle development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062224 ! positive regulation of somatic muscle development +is_a: GO:0062226 ! regulation of adult somatic muscle development +relationship: positively_regulates GO:0007527 ! adult somatic muscle development + +[Term] +id: GO:0062228 +name: negative regulation of adult somatic muscle development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of adult somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062225 ! negative regulation of somatic muscle development +is_a: GO:0062226 ! regulation of adult somatic muscle development +relationship: negatively_regulates GO:0007527 ! adult somatic muscle development + +[Term] +id: GO:0062229 +name: regulation of larval somatic muscle development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062223 ! regulation of somatic muscle development +relationship: regulates GO:0007526 ! larval somatic muscle development + +[Term] +id: GO:0062230 +name: negative regulation of larval somatic muscle development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062225 ! negative regulation of somatic muscle development +is_a: GO:0062229 ! regulation of larval somatic muscle development +relationship: negatively_regulates GO:0007526 ! larval somatic muscle development + +[Term] +id: GO:0062231 +name: positive regulation of larval somatic muscle development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of larval somatic muscle development." [PMID:16643882, PMID:25758712] +is_a: GO:0062224 ! positive regulation of somatic muscle development +is_a: GO:0062229 ! regulation of larval somatic muscle development +relationship: positively_regulates GO:0007526 ! larval somatic muscle development + +[Term] +id: GO:0062232 +name: prostanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prostanoids." [PMID:25449649] +is_a: GO:1901523 ! icosanoid catabolic process + +[Term] +id: GO:0062233 +name: F2-isoprostane catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of F2-isoprostane." [PMID:16371369, PMID:25449649] +is_a: GO:1901523 ! icosanoid catabolic process + +[Term] +id: GO:0062234 +name: platelet activating factor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of platelet activating factor, 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine." [PMID:16371369] +synonym: "2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine catabolic process" EXACT [] +synonym: "PAF catabolic process" RELATED [] +is_a: GO:0044269 ! glycerol ether catabolic process +is_a: GO:0046469 ! platelet activating factor metabolic process +is_a: GO:0046475 ! glycerophospholipid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0062235 +name: axonemal basal plate assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate." [PMID:23352055, PMID:30810527] +synonym: "axonemal basal plate formation" NARROW [] +synonym: "axoneme basal plate assembly" EXACT [] +synonym: "basal plate assembly" BROAD [] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0035082 ! axoneme assembly + +[Term] +id: GO:0062236 +name: ionocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an ionocyte. Ionocytes are specialized epithelial cells that contribute to osmotic homeostasis." [PMID:17555741] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0062237 +name: protein localization to postsynapse +namespace: biological_process +def: "Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell." [PMID:31189538] +is_a: GO:0035418 ! protein localization to synapse + +[Term] +id: GO:0062238 +name: Smp focus +namespace: cellular_component +def: "A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I." [PMID:22582262, PMID:31811152] +synonym: "Smp dot" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0062239 +name: heterochromatin-nuclear membrane anchor activity +namespace: molecular_function +def: "Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization." [PMID:31635174] +synonym: "heterochromatin-nuclear membrane tether activity" EXACT [] +synonym: "nuclear membrane-heterochromatin anchor activity" EXACT [] +synonym: "nuclear membrane-heterochromatin tether activity" EXACT [] +is_a: GO:0140707 ! chromatin-nuclear membrane anchor activity + +[Term] +id: GO:0062240 +name: euchromatin-nuclear membrane anchor activity +namespace: molecular_function +def: "Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization." [PMID:31635174] +synonym: "euchromatin-nuclear membrane tether activity" EXACT [] +synonym: "nuclear membrane-euchromatin anchor activity" EXACT [] +synonym: "nuclear membrane-euchromatin tether activity" EXACT [] +is_a: GO:0140707 ! chromatin-nuclear membrane anchor activity + +[Term] +id: GO:0062241 +name: double strand break-nuclear membrane anchor activity +namespace: molecular_function +def: "Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair." [PMID:31635174] +synonym: "DNA repair factory" RELATED [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0062242 +name: double membrane vesicle viral factory membrane +namespace: cellular_component +def: "One of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839] +synonym: "membrane of double membrane vesicle viral factory" EXACT [] +is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane +relationship: part_of GO:0039718 ! double membrane vesicle viral factory + +[Term] +id: GO:0062243 +name: double membrane vesicle viral factory outer membrane +namespace: cellular_component +def: "The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839] +synonym: "outer membrane of double membrane vesicle viral factory" EXACT [] +is_a: GO:0062242 ! double membrane vesicle viral factory membrane + +[Term] +id: GO:0062244 +name: double membrane vesicle viral factory lumen +namespace: cellular_component +def: "The volume surrounded by the inner membrane of a double membrane vesicle viral factory." [PMID:22440839] +synonym: "lumen of double membrane vesicle viral factory" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0039718 ! double membrane vesicle viral factory + +[Term] +id: GO:0062245 +name: double membrane vesicle viral factory inner membrane +namespace: cellular_component +def: "The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory." [PMID:22440839] +synonym: "inner membrane of double membrane vesicle viral factory" EXACT [] +is_a: GO:0062242 ! double membrane vesicle viral factory membrane + +[Term] +id: GO:0062246 +name: exocytic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by an exocytic vesicle." [PMID:27384577] +is_a: GO:0098566 ! transport vesicle lumen +relationship: part_of GO:0070382 ! exocytic vesicle + +[Term] +id: GO:0062247 +name: chloroplast vesicle +namespace: cellular_component +def: "A intracellular vesicle that is part of a chloroplast." [PMID:32245810] +is_a: GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0009507 ! chloroplast + +[Term] +id: GO:0062248 +name: cleistothecium formation +namespace: biological_process +def: "The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [PMID:20348388, PMID:28889020, PMID:30410052] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0070791 ! cleistothecium development + +[Term] +id: GO:0065001 +name: specification of axis polarity +namespace: biological_process +def: "The pattern specification process in which the polarity of a body or organ axis is established and maintained." [GOC:mah] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0009798 ! axis specification + +[Term] +id: GO:0065002 +name: intracellular protein transmembrane transport +namespace: biological_process +def: "The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore." [GOC:isa_complete] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "intracellular membrane translocation of a protein" EXACT [] +synonym: "intracellular protein membrane transport" EXACT [] +synonym: "intracellular protein transport across a membrane" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0065003 +name: protein-containing complex assembly +namespace: biological_process +alt_id: GO:0006461 +alt_id: GO:0034622 +alt_id: GO:0043623 +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_metagenomics +subset: goslim_pir +subset: goslim_pombe +synonym: "cellular macromolecule complex assembly" RELATED [] +synonym: "cellular protein complex assembly" EXACT [] +synonym: "cellular protein-containing complex assembly" RELATED [] +synonym: "chaperone activity" RELATED [] +synonym: "macromolecular complex assembly" RELATED [] +synonym: "macromolecule complex assembly" RELATED [] +synonym: "protein complex assembly" RELATED [] +synonym: "protein complex formation" RELATED [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0065004 +name: protein-DNA complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] +synonym: "DNA-protein complex assembly" EXACT [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0071824 ! protein-DNA complex subunit organization + +[Term] +id: GO:0065005 +name: protein-lipid complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex." [GOC:jl] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0071825 ! protein-lipid complex subunit organization + +[Term] +id: GO:0065007 +name: biological regulation +namespace: biological_process +def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] +subset: gocheck_do_not_annotate +subset: goslim_pir +synonym: "regulation" BROAD [] +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0065008 +name: regulation of biological quality +namespace: biological_process +def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] +subset: goslim_pir +synonym: "regulation of biological attribute" EXACT [] +synonym: "regulation of biological characteristic" EXACT [] +is_a: GO:0065007 ! biological regulation + +[Term] +id: GO:0065009 +name: regulation of molecular function +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] +subset: gocheck_do_not_annotate +subset: goslim_pir +subset: goslim_plant +synonym: "regulation of a molecular function" EXACT [] +is_a: GO:0065007 ! biological regulation + +[Term] +id: GO:0065010 +name: extracellular membrane-bounded organelle +namespace: cellular_component +def: "Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:isa_complete] +synonym: "extracellular membrane-enclosed organelle" EXACT [] +is_a: GO:0043227 ! membrane-bounded organelle +is_a: GO:0043230 ! extracellular organelle + +[Term] +id: GO:0070001 +name: aspartic-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070002 +name: glutamic-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070003 +name: threonine-type peptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070004 +name: cysteine-type exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE] +is_a: GO:0008234 ! cysteine-type peptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0070005 +name: cysteine-type aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +xref: EC:3.4.18.- +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0070004 ! cysteine-type exopeptidase activity + +[Term] +id: GO:0070006 +name: metalloaminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE] +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0008235 ! metalloexopeptidase activity + +[Term] +id: GO:0070007 +name: glutamic-type endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE] +is_a: GO:0004175 ! endopeptidase activity +is_a: GO:0070002 ! glutamic-type peptidase activity + +[Term] +id: GO:0070008 +name: serine-type exopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE] +xref: EC:3.4.21.- +is_a: GO:0008236 ! serine-type peptidase activity +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0070009 +name: serine-type aminopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +is_a: GO:0004177 ! aminopeptidase activity +is_a: GO:0070008 ! serine-type exopeptidase activity + +[Term] +id: GO:0070012 +name: oligopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds." [GOC:mah, ISBN:0198506732] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070013 +name: intracellular organelle lumen +namespace: cellular_component +def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] +subset: goslim_mouse +is_a: GO:0043233 ! organelle lumen +relationship: part_of GO:0043229 ! intracellular organelle + +[Term] +id: GO:0070014 +name: sucrase-isomaltase complex +namespace: cellular_component +def: "A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities." [PMID:3366777] +synonym: "oligo-1,6-glucosidase complex" RELATED [] +xref: Wikipedia:Sucrase-isomaltase +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1902687 ! glucosidase complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0070016 +name: armadillo repeat domain binding +namespace: molecular_function +def: "Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation." [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225] +synonym: "Arm repeat domain binding" EXACT [] +synonym: "armadillo domain binding" EXACT [] +synonym: "armadillo repeat binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070017 +name: alphav-beta3 integrin-thrombospondin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin." [PMID:2478219] +synonym: "ITGAV-ITGB3-THBS1 complex" NARROW [CORUM:2846] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070018 +name: obsolete transforming growth factor beta type I receptor homodimeric complex +namespace: cellular_component +def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers." [Reactome:R-HSA-170864] +comment: This term was made obsolete because it does not represent a physiological complex. +synonym: "TGF-beta type I receptor complex" EXACT [] +synonym: "TGF-beta type I receptor dimer" EXACT [Reactome:R-HSA-170864] +synonym: "TGFBR1 homodimer" EXACT [Reactome:R-HSA-170864] +synonym: "transforming growth factor beta type I receptor complex" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0070019 +name: obsolete transforming growth factor beta type II receptor homodimeric complex +namespace: cellular_component +def: "OBSOLETE. A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers." [Reactome:R-HSA-170866] +comment: This term was made obsolete because it does not represent a physiological complex. +synonym: "TGF-beta type II receptor complex" EXACT [] +synonym: "TGF-beta type II receptor dimer" EXACT [Reactome:R-HSA-170866] +synonym: "TGFBR2 homodimer" EXACT [Reactome:R-HSA-170866] +synonym: "transforming growth factor beta type II receptor complex" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0070020 +name: obsolete transforming growth factor beta1-type II receptor complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that consists of a dimeric transforming growth factor beta (TGF-beta) type II receptor bound to a TGF-beta1 dimer." [Reactome:R-HSA-170865] +comment: This term was made obsolete because it does not represent a physiological complex. +synonym: "TGF-beta receptor II-TGF-beta1 complex" EXACT [] +synonym: "TGF-beta1-type II receptor complex" EXACT [Reactome:R-HSA-170865] +is_obsolete: true + +[Term] +id: GO:0070021 +name: transforming growth factor beta ligand-receptor complex +namespace: cellular_component +def: "A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand." [Reactome:R-HSA-170840] +synonym: "TGF-beta 1:type II receptor:type I receptor complex" NARROW [Reactome:R-HSA-170840] +synonym: "TGF-beta ligand-receptor complex" EXACT [] +synonym: "TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex" NARROW [] +synonym: "TGF-beta1 ligand-receptor complex" NARROW [] +synonym: "TGF-beta1-beta2 ligand-receptor complex" NARROW [] +synonym: "TGF-beta1-type II receptor-type I receptor complex" NARROW [] +synonym: "TGF-beta2 ligand-receptor complex" NARROW [] +synonym: "TGFb ligand-receptor complex" EXACT [] +synonym: "TGFbeta ligand-receptor complex" EXACT [] +synonym: "TGFbeta1 ligand-receptor complex" NARROW [] +synonym: "TGFbeta1-beta2 ligand-receptor complex" NARROW [] +synonym: "TGFbeta2 ligand-receptor complex" NARROW [] +synonym: "transforming growth factor beta1-type II receptor-type I receptor complex" NARROW [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0070022 +name: obsolete transforming growth factor beta receptor complex +namespace: cellular_component +def: "OBSOLETE. A homodimeric receptor complex that consists of two TGF-beta receptor monomers." [GOC:mah, Reactome:R-HSA-170864, Reactome:R-HSA-170866] +comment: This term was made obsolete because it does not represent a physiological complex. +synonym: "TGF-beta receptor complex" BROAD [] +synonym: "transforming growth factor beta receptor complex" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0070023 +name: interleukin-12-interleukin-12 receptor complex +namespace: cellular_component +def: "A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer." [PMID:11900991] +synonym: "IL12-IL12 receptor complex" EXACT [] +synonym: "IL12B-IL12RB1-IL12RB2 complex" NARROW [CORUM:2020] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070024 +name: CD19-Vav-PIK3R1 complex +namespace: cellular_component +def: "A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K)." [PMID:7528218] +synonym: "CD19-Vav-PI 3-kinase (p85 subunit) complex" EXACT [CORUM:2574] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070025 +name: carbon monoxide binding +namespace: molecular_function +def: "Binding to carbon monoxide (CO)." [GOC:ecd] +synonym: "CO binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0070026 +name: nitric oxide binding +namespace: molecular_function +def: "Binding to nitric oxide (NO)." [GOC:ecd] +synonym: "nitrogen monoxide binding" EXACT [] +synonym: "nitrosyl binding" EXACT [CHEBI:16480] +synonym: "NO binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0070027 +name: carbon monoxide sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO)." [GOC:ecd] +is_a: GO:0070025 ! carbon monoxide binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0070028 +name: obsolete regulation of transcription by carbon monoxide +namespace: biological_process +def: "OBSOLETE. Any process involving carbon monoxide that modulates the frequency, rate or extent of transcription." [GOC:ecd] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of transcription by CO" EXACT [] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:0070029 +name: alphav-beta3 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin." [PMID:7532190] +synonym: "ITGAV-ITGB3-SPP1 complex" NARROW [CORUM:2358] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070030 +name: alphav-beta1 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin." [PMID:7592829] +synonym: "ITGAV-ITGB1-SPP1 complex" NARROW [CORUM:2885] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070031 +name: alphav-beta5 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin." [PMID:7592829] +synonym: "ITGAV-ITGB5-SPP1 complex" NARROW [CORUM:2347] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070032 +name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof)." [PMID:7553862] +synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx1)" NARROW [CORUM:795] +synonym: "Vamp2-Snap25-Stx1a-Cplx1 complex" NARROW [CORUM:795] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070033 +name: synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof)." [PMID:7553862] +synonym: "SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)" NARROW [CORUM:796] +synonym: "Vamp2-Snap25-Stx1a-Cplx2 complex" NARROW [CORUM:796] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070034 +name: telomerase RNA binding +namespace: molecular_function +def: "Binding to the telomerase RNA template." [GOC:krc, PMID:16884717] +synonym: "TERC binding" RELATED [GOC:dph] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0070035 +name: obsolete purine NTP-dependent helicase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] +comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo), therefore this term was an unnecessary grouping term. +is_obsolete: true + +[Term] +id: GO:0070036 +name: obsolete GTP-dependent helicase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] +comment: The reason for obsoletion is that helicases only and always use ATP (although under very specific experimental conditions GTP can perhaps be used; this is not the case in vivo). +is_obsolete: true + +[Term] +id: GO:0070037 +name: rRNA (pseudouridine) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule." [GOC:imk, GOC:mah] +xref: Reactome:R-HSA-6790906 "EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248" +is_a: GO:0008649 ! rRNA methyltransferase activity + +[Term] +id: GO:0070038 +name: rRNA (pseudouridine-N3-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine." [GOC:imk, GOC:mah] +is_a: GO:0070037 ! rRNA (pseudouridine) methyltransferase activity + +[Term] +id: GO:0070039 +name: rRNA (guanosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine." [GOC:imk, GOC:mah] +xref: Reactome:R-HSA-6793096 "MRM3 (RNMTL1) methylates guanosine-1370 of 16S rRNA yielding 2'-O-methylguanosine-1370" +xref: Reactome:R-HSA-6793122 "MRM1 methylates guanosine-1145 of 16S rRNA yielding 2'-O-methylguanosine-1145" +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0070040 +name: rRNA (adenine-C2-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA." [GOC:imk, PMID:20007606, PMID:20184321, PMID:21368151, PMID:21415317, PMID:21527678] +xref: EC:2.1.1.192 +xref: MetaCyc:RXN-11586 +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0070041 +name: rRNA (uridine-C5-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine." [GOC:imk, GOC:mah] +is_a: GO:0008169 ! C-methyltransferase activity +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity + +[Term] +id: GO:0070042 +name: rRNA (uridine-N3-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine." [GOC:imk, GOC:mah] +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity + +[Term] +id: GO:0070043 +name: rRNA (guanine-N7-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine." [GOC:imk, GOC:mah] +xref: Reactome:R-HSA-6790982 "WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639" +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity + +[Term] +id: GO:0070044 +name: synaptobrevin 2-SNAP-25-syntaxin-1a complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] +synonym: "Snap25-Stx1a-Vamp2 complex" NARROW [] +synonym: "SNARE complex (Snap25, Stx1a, Vamp2)" NARROW [CORUM:998] +synonym: "SNARE complex (Stx1a, SNAP25, VAMP)" NARROW [CORUM:841] +synonym: "Stx1a-SNAP25-VAMP complex" NARROW [CORUM:841] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070045 +name: synaptobrevin 2-SNAP-25-syntaxin-2 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx2, Snap25, Vamp2)" NARROW [CORUM:851] +synonym: "Stx2-Snap25-Vamp2 complex" NARROW [CORUM:851] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070046 +name: synaptobrevin 2-SNAP-25-syntaxin-3 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx3, Snap25, Vamp2)" NARROW [CORUM:852] +synonym: "Stx3-Snap25-Vamp2 complex" NARROW [CORUM:852] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070047 +name: synaptobrevin 2-SNAP-25-syntaxin-4 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx4, Snap25, Vamp2)" NARROW [CORUM:853] +synonym: "Stx4-Snap25-Vamp2 complex" NARROW [CORUM:853] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070048 +name: endobrevin-SNAP-25-syntaxin-1a complex +namespace: cellular_component +def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx1a, Snap25, Vamp8)" NARROW [CORUM:854] +synonym: "Stx1a-Snap25-Vamp8 complex" NARROW [CORUM:854] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070049 +name: endobrevin-SNAP-25-syntaxin-2 complex +namespace: cellular_component +def: "A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof)." [PMID:10336434] +synonym: "SNARE complex (Stx2, Snap25, Vamp8)" NARROW [CORUM:855] +synonym: "Stx2-Snap25-Vamp8 complex" NARROW [CORUM:855] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070050 +name: neuron cellular homeostasis +namespace: biological_process +def: "The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state." [GOC:BHF, GOC:mah] +synonym: "neuron maintenance" EXACT [] +is_a: GO:0019725 ! cellular homeostasis +is_a: GO:0060249 ! anatomical structure homeostasis + +[Term] +id: GO:0070051 +name: fibrinogen binding +namespace: molecular_function +def: "Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade." [GOC:BHF, GOC:mah, GOC:vk] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0070052 +name: collagen V binding +namespace: molecular_function +def: "Binding to a type V collagen trimer." [GOC:BHF, GOC:mah] +is_a: GO:0005518 ! collagen binding + +[Term] +id: GO:0070053 +name: thrombospondin receptor activity +namespace: molecular_function +def: "Combining with thrombospondin and transmitting the signal to initiate a change in cell activity." [GOC:BHF, GOC:signaling, GOC:vk] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0070054 +name: mRNA splicing, via endonucleolytic cleavage and ligation +namespace: biological_process +alt_id: GO:0061012 +def: "Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, GOC:mah] +comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. +synonym: "cytosolic mRNA splicing" RELATED [] +is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0070055 +name: obsolete mRNA endonucleolytic cleavage involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. The endonucleolytic cleavage of a mRNA containing an HAC1-type intron at the 5' and 3' splice sites. The cleavage step is part of unconventional mRNA splicing, and contributes to the endoplasmic reticulum unfolded protein response." [GOC:bf, GOC:krc, GOC:mah, PMID:10357823] +comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). +synonym: "ERN1-mediated XBP-1 mRNA cleavage" RELATED [HGNC:3449] +synonym: "HAC1 mRNA cleavage" NARROW [GOC:bf] +synonym: "HAC1-type intron splice site recognition and cleavage" NARROW [] +synonym: "IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:bf] +synonym: "XBP1 mRNA cleavage" NARROW [GOC:bf] +is_obsolete: true +consider: GO:0036498 + +[Term] +id: GO:0070056 +name: prospore membrane leading edge +namespace: cellular_component +def: "The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization." [GOC:mah, PMID:14702385] +synonym: "forespore membrane leading edge" EXACT [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0005628 ! prospore membrane + +[Term] +id: GO:0070057 +name: prospore membrane spindle pole body attachment site +namespace: cellular_component +def: "The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus." [GOC:mah, PMID:14702385] +synonym: "forespore membrane SPB attachment site" EXACT [] +synonym: "forespore membrane spindle pole body attachment site" EXACT [] +synonym: "prospore membrane SPB attachment site" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005628 ! prospore membrane + +[Term] +id: GO:0070058 +name: tRNA gene clustering +namespace: biological_process +def: "The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae." [GOC:jh, GOC:mah, PMID:18708579] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0070059 +name: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:mah, GOC:mtg_apoptosis, PMID:18701708] +synonym: "apoptosis in response to endoplasmic reticulum stress" BROAD [] +synonym: "apoptosis in response to ER stress" EXACT [] +synonym: "apoptosis triggered by ER stress" EXACT [] +synonym: "endoplasmic reticulum stress-induced apoptosis" EXACT [] +synonym: "ER stress-induced apoptosis" EXACT [] +synonym: "intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [] +is_a: GO:0034976 ! response to endoplasmic reticulum stress +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:0070060 +name: 'de novo' actin filament nucleation +namespace: biological_process +def: "The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament." [GOC:mah, PMID:17477841] +synonym: "formin-mediated actin filament nucleation" NARROW [] +synonym: "unbranched actin filament nucleation" RELATED [] +is_a: GO:0045010 ! actin nucleation + +[Term] +id: GO:0070061 +name: fructose binding +namespace: molecular_function +def: "Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:0070062 +name: extracellular exosome +namespace: cellular_component +def: "A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm." [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] +synonym: "exosome" EXACT [GOC:pr] +synonym: "extracellular vesicular exosome" EXACT [GOC:vesicles] +is_a: GO:1903561 ! extracellular vesicle +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0070063 +name: RNA polymerase binding +namespace: molecular_function +def: "Binding to an RNA polymerase molecule or complex." [GOC:BHF, GOC:mah, GOC:txnOH] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0070064 +name: proline-rich region binding +namespace: molecular_function +def: "Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein." [GOC:mah] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070065 +name: cellubrevin-VAMP4-syntaxin-16 complex +namespace: cellular_component +def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp3, Vamp4, Stx16)" NARROW [CORUM:875] +synonym: "Vamp3-Vamp4-Stx16 complex" NARROW [CORUM:875] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070066 +name: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex +namespace: cellular_component +def: "A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp3, Vamp4, Vam8, Stx6)" NARROW [CORUM:874] +synonym: "Vamp3-Vamp4-Vam8-Stx6 complex" NARROW [CORUM:874] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070067 +name: syntaxin-6-syntaxin-16-Vti1a complex +namespace: cellular_component +def: "A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070068 +name: VAMP4-syntaxin-6-syntaxin-16-Vti1a complex +namespace: cellular_component +def: "A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof)." [PMID:11839770] +synonym: "SNARE complex (Vamp4, Stx6, Stx16, Vti1a)" NARROW [CORUM:877] +synonym: "Vamp4-Stx6-Stx16-Vti1a complex" RELATED [CORUM:877] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070069 +name: cytochrome complex +namespace: cellular_component +def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0070070 +name: proton-transporting V-type ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient." [GOC:mah] +synonym: "V-ATPase assembly" RELATED [] +synonym: "V-ATPase complex assembly" RELATED [] +is_a: GO:0070071 ! proton-transporting two-sector ATPase complex assembly + +[Term] +id: GO:0070071 +name: proton-transporting two-sector ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane." [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0070072 +name: vacuolar proton-transporting V-type ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane." [GOC:BHF, GOC:mah] +synonym: "V-ATPase assembly" BROAD [] +synonym: "V-ATPase complex assembly" BROAD [] +is_a: GO:0070070 ! proton-transporting V-type ATPase complex assembly + +[Term] +id: GO:0070073 +name: clustering of voltage-gated calcium channels +namespace: biological_process +def: "The process in which voltage-gated calcium channels become localized together in high densities." [GOC:BHF, GOC:sart, PMID:18385325] +synonym: "clustering of voltage gated calcium channels" EXACT [] +synonym: "clustering of voltage-dependent calcium channels" EXACT [] +synonym: "voltage-gated calcium channel clustering" EXACT [] +is_a: GO:0045161 ! neuronal ion channel clustering + +[Term] +id: GO:0070074 +name: mononeme +namespace: cellular_component +def: "A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts." [GOC:BHF, PMID:18048320] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0020007 ! apical complex + +[Term] +id: GO:0070075 +name: tear secretion +namespace: biological_process +def: "The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium." [GOC:rph] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0032941 ! secretion by tissue + +[Term] +id: GO:0070076 +name: histone lysine demethylation +namespace: biological_process +def: "The modification of a histone by the removal of a methyl group from a lysine residue." [GOC:mah] +is_a: GO:0016577 ! histone demethylation + +[Term] +id: GO:0070077 +name: histone arginine demethylation +namespace: biological_process +def: "The modification of a histone by the removal of a methyl group from an arginine residue." [GOC:mah] +is_a: GO:0016577 ! histone demethylation + +[Term] +id: GO:0070078 +name: histone H3-R2 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone." [GOC:BHF, GOC:vk] +is_a: GO:0070077 ! histone arginine demethylation + +[Term] +id: GO:0070079 +name: histone H4-R3 demethylation +namespace: biological_process +def: "The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone." [GOC:BHF, GOC:vk] +is_a: GO:0070077 ! histone arginine demethylation + +[Term] +id: GO:0070080 +name: titin Z domain binding +namespace: molecular_function +def: "Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34." [GOC:mah, InterPro:IPR015129] +synonym: "Z repeat domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070081 +name: clathrin-sculpted monoamine transport vesicle +namespace: cellular_component +def: "A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines." [GOC:mg2] +synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle" EXACT [] +synonym: "clathrin sculpted monoamine transport vesicle" EXACT [GOC:sl] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0060198 ! clathrin-sculpted vesicle + +[Term] +id: GO:0070082 +name: clathrin-sculpted monoamine transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle." [GOC:mg2] +synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen" EXACT [] +synonym: "clathrin sculpted monoamine transport vesicle lumen" EXACT [GOC:sl] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle + +[Term] +id: GO:0070083 +name: clathrin-sculpted monoamine transport vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle." [GOC:mg2] +synonym: "clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane" EXACT [] +synonym: "clathrin sculpted monoamine transport vesicle membrane" EXACT [GOC:sl] +is_a: GO:0030658 ! transport vesicle membrane +is_a: GO:0030665 ! clathrin-coated vesicle membrane +relationship: part_of GO:0070081 ! clathrin-sculpted monoamine transport vesicle + +[Term] +id: GO:0070084 +name: protein initiator methionine removal +namespace: biological_process +def: "The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein." [GOC:imk, GOC:mah] +synonym: "removal of initiator methionine from protein" EXACT [] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0070085 +name: glycosylation +namespace: biological_process +def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah] +xref: Wikipedia:Glycosylation +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0070086 +name: ubiquitin-dependent endocytosis +namespace: biological_process +def: "Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded." [GOC:jp, GOC:mah, PMID:9409540] +synonym: "ubiquitin-mediated endocytosis" EXACT [GOC:jp] +is_a: GO:0006897 ! endocytosis +is_a: GO:0015031 ! protein transport +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0070087 +name: chromo shadow domain binding +namespace: molecular_function +def: "Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain." [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093] +synonym: "chromoshadow domain binding" EXACT [GOC:vk] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070088 +name: PHA granule +namespace: cellular_component +def: "An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR." [GOC:mah, PMID:15762612] +synonym: "PHB granule" NARROW [] +synonym: "polyhydroxyalkanoate granule" EXACT [] +is_a: GO:0016234 ! inclusion body +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070089 +name: chloride-activated potassium channel activity +namespace: molecular_function +def: "Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:kmv, GOC:mtg_transport] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0022839 ! ion gated channel activity + +[Term] +id: GO:0070090 +name: metaphase plate +namespace: cellular_component +def: "The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division." [GOC:mah] +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0070091 +name: glucagon secretion +namespace: biological_process +def: "The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans)." [GOC:BHF, GOC:rl] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0070092 +name: regulation of glucagon secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070093 +name: negative regulation of glucagon secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] +synonym: "down regulation of glucagon secretion" EXACT [] +synonym: "down-regulation of glucagon secretion" EXACT [] +synonym: "downregulation of glucagon secretion" EXACT [] +synonym: "inhibition of glucagon secretion" NARROW [] +is_a: GO:0070092 ! regulation of glucagon secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070094 +name: positive regulation of glucagon secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon." [GOC:BHF, GOC:mah] +synonym: "activation of glucagon secretion" NARROW [] +synonym: "stimulation of glucagon secretion" NARROW [] +synonym: "up regulation of glucagon secretion" EXACT [] +synonym: "up-regulation of glucagon secretion" EXACT [] +synonym: "upregulation of glucagon secretion" EXACT [] +is_a: GO:0070092 ! regulation of glucagon secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0070091 ! glucagon secretion + +[Term] +id: GO:0070095 +name: fructose-6-phosphate binding +namespace: molecular_function +def: "Binding to fructose 6-phosphate." [GOC:mah] +synonym: "D-fructose 6-phosphate binding" NARROW [] +synonym: "fructose 6-phosphate binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0070096 +name: mitochondrial outer membrane translocase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex." [GOC:BHF, GOC:vk] +synonym: "mitochondrion outer membrane translocase complex assembly" EXACT [] +synonym: "TOM complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0007008 ! outer mitochondrial membrane organization + +[Term] +id: GO:0070097 +name: delta-catenin binding +namespace: molecular_function +def: "Binding to the delta subunit of the catenin complex." [GOC:rph] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070098 +name: chemokine-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] +synonym: "chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:1990869 ! cellular response to chemokine + +[Term] +id: GO:0070099 +name: regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070100 +name: negative regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "negative regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway +relationship: negatively_regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070101 +name: positive regulation of chemokine-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor." [GOC:mah] +synonym: "positive regulation of chemokine-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway +relationship: positively_regulates GO:0070098 ! chemokine-mediated signaling pathway + +[Term] +id: GO:0070102 +name: interleukin-6-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] +synonym: "IL-6-mediated signaling pathway" RELATED [] +synonym: "interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071354 ! cellular response to interleukin-6 + +[Term] +id: GO:0070103 +name: regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070104 +name: negative regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "negative regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway +relationship: negatively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070105 +name: positive regulation of interleukin-6-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "positive regulation of IL-6-mediated signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of interleukin-6-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0070103 ! regulation of interleukin-6-mediated signaling pathway +relationship: positively_regulates GO:0070102 ! interleukin-6-mediated signaling pathway + +[Term] +id: GO:0070106 +name: interleukin-27-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:BHF, GOC:mah, GOC:signaling] +synonym: "IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070107 +name: regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27-mediated binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070108 +name: negative regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "negative regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway +relationship: negatively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070109 +name: positive regulation of interleukin-27-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor." [GOC:BHF, GOC:mah] +synonym: "positive regulation of IL-27-mediated signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of IL27RA/IL6ST signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of interleukin-27-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0070107 ! regulation of interleukin-27-mediated signaling pathway +relationship: positively_regulates GO:0070106 ! interleukin-27-mediated signaling pathway + +[Term] +id: GO:0070110 +name: ciliary neurotrophic factor receptor complex +namespace: cellular_component +def: "A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR." [GOC:BHF, GOC:mah, GOC:rl, PMID:12707266] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0070111 +name: organellar chromatophore +namespace: cellular_component +def: "A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora." [GOC:expert_mm, PMID:18356055] +synonym: "Paulinella-type chromatophore" EXACT [] +is_a: GO:0043660 ! bacteroid-containing symbiosome + +[Term] +id: GO:0070112 +name: organellar chromatophore membrane +namespace: cellular_component +def: "Either of the lipid bilayers that surround an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore membrane" EXACT [GOC:mah] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070113 +name: organellar chromatophore inner membrane +namespace: cellular_component +def: "The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore inner membrane" EXACT [GOC:mah] +is_a: GO:0070112 ! organellar chromatophore membrane + +[Term] +id: GO:0070114 +name: organellar chromatophore outer membrane +namespace: cellular_component +def: "The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore outer membrane" EXACT [GOC:mah] +is_a: GO:0043661 ! peribacteroid membrane +is_a: GO:0070112 ! organellar chromatophore membrane + +[Term] +id: GO:0070115 +name: organellar chromatophore intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers that surround an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore intermembrane space" EXACT [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070116 +name: organellar chromatophore thylakoid +namespace: cellular_component +def: "A thylakoid located in an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore thylakoid" EXACT [GOC:mah] +is_a: GO:0009579 ! thylakoid +relationship: part_of GO:0070111 ! organellar chromatophore + +[Term] +id: GO:0070117 +name: organellar chromatophore thylakoid lumen +namespace: cellular_component +def: "The volume enclosed by an organellar chromatophore thylakoid membrane." [GOC:mah] +synonym: "Paulinella-type chromatophore thylakoid lumen" EXACT [GOC:mah] +is_a: GO:0031977 ! thylakoid lumen +relationship: part_of GO:0070116 ! organellar chromatophore thylakoid + +[Term] +id: GO:0070118 +name: organellar chromatophore thylakoid membrane +namespace: cellular_component +def: "The lipid bilayer membrane of any thylakoid within an organellar chromatophore." [GOC:mah] +synonym: "Paulinella-type chromatophore thylakoid membrane" EXACT [GOC:mah] +is_a: GO:0042651 ! thylakoid membrane +is_a: GO:0070112 ! organellar chromatophore membrane +relationship: part_of GO:0070116 ! organellar chromatophore thylakoid + +[Term] +id: GO:0070119 +name: ciliary neurotrophic factor binding +namespace: molecular_function +def: "Binding to the cytokine ciliary neurotrophic factor." [GOC:BHF, GOC:mah] +synonym: "CNTF binding" EXACT [GOC:mah] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0070120 +name: ciliary neurotrophic factor-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah] +synonym: "ciliary neurotrophic factor-mediated signalling pathway" EXACT [GOC:mah] +synonym: "CNTF-mediated signaling pathway" EXACT [GOC:rl] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070121 +name: Kupffer's vesicle development +namespace: biological_process +def: "The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period." [GOC:dgh] +synonym: "KV development" EXACT [GOC:dgh] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0070122 +name: isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond)." [GOC:mah, Wikipedia:Isopeptidase] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0070123 +name: transforming growth factor beta receptor activity, type III +namespace: molecular_function +def: "Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors." [GOC:BHF, GOC:mah, PMID:9759503] +synonym: "betaglycan" NARROW [] +synonym: "endoglin" NARROW [] +synonym: "transforming growth factor beta ligand binding to type III receptor" RELATED [] +synonym: "type III TGF-beta receptor activity" EXACT [] +synonym: "type III TGFbeta receptor activity" EXACT [] +synonym: "type III transforming growth factor beta receptor activity" EXACT [] +is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity + +[Term] +id: GO:0070124 +name: mitochondrial translational initiation +namespace: biological_process +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:mah] +synonym: "mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0006413 ! translational initiation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070125 +name: mitochondrial translational elongation +namespace: biological_process +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion." [GOC:mah] +synonym: "mitochondrial translation elongation" EXACT [GOC:mah] +is_a: GO:0006414 ! translational elongation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070126 +name: mitochondrial translational termination +namespace: biological_process +def: "The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa)." [GOC:mah, http://mitogenome.org/index.php/Genetic_Code_of_mitochondria] +synonym: "mitochondrial translation termination" EXACT [GOC:mah] +is_a: GO:0006415 ! translational termination +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070127 +name: tRNA aminoacylation for mitochondrial protein translation +namespace: biological_process +def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion." [GOC:mah] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0006418 ! tRNA aminoacylation for protein translation +relationship: part_of GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070129 +name: regulation of mitochondrial translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0062125 ! regulation of mitochondrial gene expression +relationship: regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070130 +name: negative regulation of mitochondrial translation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "negative regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:0070129 ! regulation of mitochondrial translation +relationship: negatively_regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070131 +name: positive regulation of mitochondrial translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." [GOC:mah] +synonym: "positive regulation of mitochondrial protein anabolism" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein formation" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial protein synthesis" EXACT [GOC:mah] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0070129 ! regulation of mitochondrial translation +relationship: positively_regulates GO:0032543 ! mitochondrial translation + +[Term] +id: GO:0070132 +name: regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0070129 ! regulation of mitochondrial translation +relationship: regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070133 +name: negative regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "negative regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0045947 ! negative regulation of translational initiation +is_a: GO:0070132 ! regulation of mitochondrial translational initiation +relationship: negatively_regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070134 +name: positive regulation of mitochondrial translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion." [GOC:mah] +synonym: "positive regulation of mitochondrial translation initiation" EXACT [GOC:mah] +is_a: GO:0045948 ! positive regulation of translational initiation +is_a: GO:0070131 ! positive regulation of mitochondrial translation +is_a: GO:0070132 ! regulation of mitochondrial translational initiation +relationship: positively_regulates GO:0070124 ! mitochondrial translational initiation + +[Term] +id: GO:0070135 +name: beta-1,2-oligomannoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] +synonym: "beta-1,2-oligomannoside metabolism" EXACT [GOC:mah] +is_a: GO:0010412 ! mannan metabolic process + +[Term] +id: GO:0070136 +name: beta-1,2-oligomannoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan." [GOC:mah, PMID:18234669] +synonym: "beta-1,2-oligomannoside anabolism" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside biosynthesis" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside formation" EXACT [GOC:mah] +synonym: "beta-1,2-oligomannoside synthesis" EXACT [GOC:mah] +is_a: GO:0046354 ! mannan biosynthetic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process +is_a: GO:0070135 ! beta-1,2-oligomannoside metabolic process + +[Term] +id: GO:0070137 +name: ubiquitin-like protein-specific endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO)." [GOC:mah] +synonym: "small conjugating protein-specific endopeptidase activity" EXACT [] +is_a: GO:0004197 ! cysteine-type endopeptidase activity +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0070138 +name: ubiquitin-like protein-specific isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated." [GOC:mah] +synonym: "small conjugating protein-specific isopeptidase activity" EXACT [GOC:dph] +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity +is_a: GO:0070122 ! isopeptidase activity + +[Term] +id: GO:0070139 +name: SUMO-specific endopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO." [GOC:mah] +xref: Reactome:R-HSA-2990840 "SENP1,2,5 proteolytically process SUMO1" +xref: Reactome:R-HSA-2990842 "SENP1,2,5 proteolytically process SUMO2" +xref: Reactome:R-HSA-2993763 "SENP1,2,5 proteolytically process SUMO3" +is_a: GO:0016929 ! SUMO-specific protease activity +is_a: GO:0070137 ! ubiquitin-like protein-specific endopeptidase activity + +[Term] +id: GO:0070140 +name: SUMO-specific isopeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated." [GOC:mah] +is_a: GO:0016929 ! SUMO-specific protease activity +is_a: GO:0070138 ! ubiquitin-like protein-specific isopeptidase activity + +[Term] +id: GO:0070141 +name: response to UV-A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:BHF, GOC:mah] +synonym: "response to UV-A light stimulus" EXACT [] +synonym: "response to UV-A radiation stimulus" EXACT [] +synonym: "response to UVA light stimulus" EXACT [] +synonym: "response to UVA radiation stimulus" EXACT [] +is_a: GO:0009411 ! response to UV + +[Term] +id: GO:0070142 +name: synaptic vesicle budding +namespace: biological_process +def: "Evagination of a membrane to form a synaptic vesicle." [GOC:mah] +is_a: GO:0006900 ! vesicle budding from membrane +relationship: part_of GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:0070143 +name: mitochondrial alanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006419 ! alanyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070144 +name: mitochondrial arginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006420 ! arginyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070145 +name: mitochondrial asparaginyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006421 ! asparaginyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070146 +name: mitochondrial aspartyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006422 ! aspartyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070147 +name: mitochondrial cysteinyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006423 ! cysteinyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070148 +name: mitochondrial glutaminyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006425 ! glutaminyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070149 +name: mitochondrial glutamyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006424 ! glutamyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070150 +name: mitochondrial glycyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006426 ! glycyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070151 +name: mitochondrial histidyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006427 ! histidyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070152 +name: mitochondrial isoleucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006428 ! isoleucyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070153 +name: mitochondrial leucyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006429 ! leucyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070154 +name: mitochondrial lysyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006430 ! lysyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070155 +name: mitochondrial methionyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006431 ! methionyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070156 +name: mitochondrial phenylalanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006432 ! phenylalanyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070157 +name: mitochondrial prolyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006433 ! prolyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070158 +name: mitochondrial seryl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006434 ! seryl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070159 +name: mitochondrial threonyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006435 ! threonyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070160 +name: tight junction +namespace: cellular_component +def: "A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [ISBN:0815332181] +synonym: "occluding cell junction" EXACT [GOC:mah] +synonym: "occluding junction" EXACT [GOC:mah] +xref: Wikipedia:Tight_junction +is_a: GO:0005911 ! cell-cell junction + +[Term] +id: GO:0070161 +name: anchoring junction +namespace: cellular_component +def: "A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix." [ISBN:0815332181] +synonym: "anchoring cell junction" EXACT [GOC:mah] +is_a: GO:0030054 ! cell junction + +[Term] +id: GO:0070162 +name: adiponectin secretion +namespace: biological_process +def: "The regulated release of adiponectin, a protein hormone, by adipose tissue." [GOC:BHF, GOC:rl] +is_a: GO:0009306 ! protein secretion +is_a: GO:0060986 ! endocrine hormone secretion + +[Term] +id: GO:0070163 +name: regulation of adiponectin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:mah] +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0070162 ! adiponectin secretion + +[Term] +id: GO:0070164 +name: negative regulation of adiponectin secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah] +synonym: "down regulation of adiponectin secretion" EXACT [GOC:mah] +synonym: "down-regulation of adiponectin secretion" EXACT [GOC:mah] +synonym: "downregulation of adiponectin secretion" EXACT [GOC:mah] +synonym: "inhibition of adiponectin secretion" NARROW [GOC:mah] +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070163 ! regulation of adiponectin secretion +relationship: negatively_regulates GO:0070162 ! adiponectin secretion + +[Term] +id: GO:0070165 +name: positive regulation of adiponectin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell." [GOC:BHF, GOC:mah] +synonym: "activation of adiponectin secretion" NARROW [GOC:mah] +synonym: "stimulation of adiponectin secretion" NARROW [GOC:mah] +synonym: "up regulation of adiponectin secretion" EXACT [GOC:mah] +synonym: "up-regulation of adiponectin secretion" EXACT [GOC:mah] +synonym: "upregulation of adiponectin secretion" EXACT [GOC:mah] +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070163 ! regulation of adiponectin secretion +relationship: positively_regulates GO:0070162 ! adiponectin secretion + +[Term] +id: GO:0070166 +name: enamel mineralization +namespace: biological_process +def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel." [GOC:BHF, GOC:mah, GOC:sl, PMID:10206335, PMID:16931858, PMID:21196346] +synonym: "enamel formation" RELATED [PMID:16931858] +is_a: GO:0034505 ! tooth mineralization +relationship: part_of GO:0097186 ! amelogenesis + +[Term] +id: GO:0070167 +name: regulation of biomineral tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] +is_a: GO:0110149 ! regulation of biomineralization +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0031214 ! biomineral tissue development + +[Term] +id: GO:0070168 +name: negative regulation of biomineral tissue development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070167 ! regulation of biomineral tissue development +is_a: GO:0110150 ! negative regulation of biomineralization +relationship: negatively_regulates GO:0031214 ! biomineral tissue development + +[Term] +id: GO:0070169 +name: positive regulation of biomineral tissue development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds." [GOC:mah] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070167 ! regulation of biomineral tissue development +is_a: GO:0110151 ! positive regulation of biomineralization +relationship: positively_regulates GO:0031214 ! biomineral tissue development + +[Term] +id: GO:0070170 +name: regulation of tooth mineralization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] +is_a: GO:0070167 ! regulation of biomineral tissue development +relationship: regulates GO:0034505 ! tooth mineralization + +[Term] +id: GO:0070171 +name: negative regulation of tooth mineralization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] +is_a: GO:0070168 ! negative regulation of biomineral tissue development +is_a: GO:0070170 ! regulation of tooth mineralization +relationship: negatively_regulates GO:0034505 ! tooth mineralization + +[Term] +id: GO:0070172 +name: positive regulation of tooth mineralization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures." [GOC:BHF, GOC:mah] +is_a: GO:0070169 ! positive regulation of biomineral tissue development +is_a: GO:0070170 ! regulation of tooth mineralization +relationship: positively_regulates GO:0034505 ! tooth mineralization + +[Term] +id: GO:0070173 +name: regulation of enamel mineralization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] +is_a: GO:0070170 ! regulation of tooth mineralization +relationship: regulates GO:0070166 ! enamel mineralization + +[Term] +id: GO:0070174 +name: negative regulation of enamel mineralization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] +is_a: GO:0070171 ! negative regulation of tooth mineralization +is_a: GO:0070173 ! regulation of enamel mineralization +relationship: negatively_regulates GO:0070166 ! enamel mineralization + +[Term] +id: GO:0070175 +name: positive regulation of enamel mineralization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." [GOC:BHF, GOC:mah] +is_a: GO:0070172 ! positive regulation of tooth mineralization +is_a: GO:0070173 ! regulation of enamel mineralization +relationship: positively_regulates GO:0070166 ! enamel mineralization + +[Term] +id: GO:0070176 +name: DRM complex +namespace: cellular_component +def: "A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification." [PMID:17075059] +synonym: "DP/Rb/MuvB" EXACT [PMID:17075059] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0070177 +name: contractile vacuole discharge +namespace: biological_process +def: "The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane." [GOC:mah, PMID:10369671] +is_a: GO:0045055 ! regulated exocytosis + +[Term] +id: GO:0070178 +name: D-serine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:jsg, GOC:mah] +synonym: "D-serine metabolism" EXACT [] +is_a: GO:0009069 ! serine family amino acid metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:0070179 +name: D-serine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine." [CHEBI:16523, GOC:jsg, GOC:mah] +synonym: "D-serine anabolism" EXACT [] +synonym: "D-serine biosynthesis" EXACT [] +synonym: "D-serine formation" EXACT [] +synonym: "D-serine synthesis" EXACT [] +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0046437 ! D-amino acid biosynthetic process +is_a: GO:0070178 ! D-serine metabolic process + +[Term] +id: GO:0070180 +name: large ribosomal subunit rRNA binding +namespace: molecular_function +def: "Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA." [GOC:elh] +synonym: "25S rRNA binding" EXACT [GOC:elh] +synonym: "LSU rRNA binding" EXACT [] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0070181 +name: small ribosomal subunit rRNA binding +namespace: molecular_function +def: "Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." [GOC:elh] +synonym: "18S rRNA binding" EXACT [GOC:elh] +synonym: "SSU rRNA binding" EXACT [] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:0070182 +name: DNA polymerase binding +namespace: molecular_function +def: "Binding to a DNA polymerase." [GOC:BHF, GOC:mah] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0070183 +name: mitochondrial tryptophanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006436 ! tryptophanyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070184 +name: mitochondrial tyrosyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006437 ! tyrosyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070185 +name: mitochondrial valyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, GOC:mcc] +is_a: GO:0006438 ! valyl-tRNA aminoacylation +is_a: GO:0070127 ! tRNA aminoacylation for mitochondrial protein translation + +[Term] +id: GO:0070186 +name: growth hormone activity +namespace: molecular_function +def: "The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth." [GOC:BHF, GOC:mah, PMID:11445442] +synonym: "GH activity" EXACT [PMID:11445442] +synonym: "pituitary growth hormone activity" NARROW [GOC:vk] +synonym: "placental growth hormone activity" NARROW [GOC:vk] +is_a: GO:0005179 ! hormone activity + +[Term] +id: GO:0070187 +name: shelterin complex +namespace: cellular_component +def: "A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1." [GOC:expert_mf, GOC:mah, GOC:vw, PMID:18828880] +synonym: "Pot1 complex" EXACT [GOC:vw] +synonym: "Pot1-Tpz1 complex" EXACT [GOC:vw] +synonym: "telosome" EXACT [GOC:mah, GOC:vw] +is_a: GO:0000783 ! nuclear telomere cap complex + +[Term] +id: GO:0070188 +name: obsolete Stn1-Ten1 complex +namespace: cellular_component +def: "OBSOLETE. A nuclear telomere cap complex that is formed by the association of the Stn1 and Ten1 proteins with telomeric DNA; in some species a third protein is present." [GOC:mah, GOC:vw, PMID:17715303, PMID:19064932] +comment: This term was made obsolete because it was inaccurate. +is_obsolete: true +replaced_by: GO:1990879 + +[Term] +id: GO:0070189 +name: kynurenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine." [CHEBI:28683, GOC:mah, GOC:rph] +synonym: "kynurenine metabolism" EXACT [] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:0070190 +name: obsolete inositol hexakisphosphate 1-kinase or 3-kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate, and ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate." [GOC:jp, PMID:18981179] +comment: This term was made obsolete because it represents two reactions, and should be two separate terms. +synonym: "inositol hexakisphosphate 1-kinase or 3-kinase activity" EXACT [] +is_obsolete: true +consider: GO:0052723 +consider: GO:0052724 + +[Term] +id: GO:0070191 +name: methionine-R-sulfoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin." [GOC:mcc, PMID:17535911, PMID:19049972] +is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor + +[Term] +id: GO:0070192 +name: chromosome organization involved in meiotic cell cycle +namespace: biological_process +def: "A process of chromosome organization that is involved in a meiotic cell cycle." [GOC:mah] +synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] +synonym: "meiotic chromosome organization" EXACT [GOC:mah] +is_a: GO:0051276 ! chromosome organization +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0070193 +name: synaptonemal complex organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis." [GOC:mah] +synonym: "synaptonemal complex organisation" EXACT [GOC:mah] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0070194 +name: synaptonemal complex disassembly +namespace: biological_process +def: "The controlled breakdown of a synaptonemal complex." [GOC:mah] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0070193 ! synaptonemal complex organization + +[Term] +id: GO:0070195 +name: growth hormone receptor complex +namespace: cellular_component +def: "A receptor complex that consists of two identical subunits and binds growth hormone." [GOC:BHF, GOC:mah, GOC:vk, PMID:11445442] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0070196 +name: eukaryotic translation initiation factor 3 complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex." [GOC:mah] +synonym: "eIF-3 assembly" EXACT [GOC:mah] +synonym: "eIF3 assembly" EXACT [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0070197 +name: meiotic attachment of telomere to nuclear envelope +namespace: biological_process +def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation." [GOC:jp, GOC:pr, GOC:vw, PMID:18818742] +synonym: "attachment of telomeres to nuclear envelope" BROAD [] +synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD [] +is_a: GO:0097240 ! chromosome attachment to the nuclear envelope +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0044821 ! meiotic telomere tethering at nuclear periphery + +[Term] +id: GO:0070198 +name: protein localization to chromosome, telomeric region +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] +synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah] +synonym: "protein localization to telomere" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:0070199 +name: establishment of protein localization to chromosome +namespace: biological_process +def: "The directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] +synonym: "establishment of protein localisation to chromosome" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0070200 +name: establishment of protein localization to telomere +namespace: biological_process +def: "The directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] +synonym: "establishment of protein localisation to telomere" EXACT [GOC:mah] +synonym: "establishment of protein localization to chromosome, telomeric region" EXACT [GOC:mah] +is_a: GO:0070198 ! protein localization to chromosome, telomeric region +is_a: GO:0070199 ! establishment of protein localization to chromosome + +[Term] +id: GO:0070201 +name: regulation of establishment of protein localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location." [GOC:BHF, GOC:mah] +synonym: "regulation of establishment of protein localisation" EXACT [GOC:mah] +is_a: GO:0032880 ! regulation of protein localization +relationship: regulates GO:0045184 ! establishment of protein localization + +[Term] +id: GO:0070202 +name: regulation of establishment of protein localization to chromosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome." [GOC:BHF, GOC:mah] +synonym: "regulation of establishment of protein localisation to chromosome" EXACT [GOC:mah] +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0070201 ! regulation of establishment of protein localization +relationship: regulates GO:0070199 ! establishment of protein localization to chromosome + +[Term] +id: GO:0070203 +name: regulation of establishment of protein localization to telomere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:mah] +synonym: "regulation of establishment of protein localisation to telomere" EXACT [GOC:mah] +is_a: GO:0070202 ! regulation of establishment of protein localization to chromosome +is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region +relationship: regulates GO:0070200 ! establishment of protein localization to telomere + +[Term] +id: GO:0070204 +name: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2)." [RHEA:25593] +comment: Note that this function was formerly EC:4.1.3.18. +synonym: "MenD" RELATED [EC:2.2.1.9] +synonym: "SEPHCHC synthase activity" RELATED [EC:2.2.1.9] +xref: EC:2.2.1.9 +xref: KEGG_REACTION:R08165 +xref: MetaCyc:2.5.1.64-RXN +xref: RHEA:25593 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0070205 +name: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate." [EC:4.2.99.20, RHEA:25597] +synonym: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity" RELATED [EC:4.2.99.20] +synonym: "6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity" RELATED [EC:4.2.99.20] +synonym: "MenH" RELATED [EC:4.2.99.20] +synonym: "SHCHC synthase activity" RELATED [EC:4.2.99.20] +synonym: "YfbB" RELATED [EC:4.2.99.20] +xref: EC:4.2.99.20 +xref: KEGG_REACTION:R08166 +xref: MetaCyc:RXN-9310 +xref: RHEA:25597 +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0070206 +name: protein trimerization +namespace: biological_process +def: "The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits." [GOC:hjd] +synonym: "protein trimer assembly" EXACT [GOC:hjd] +synonym: "protein trimer biosynthesis" EXACT [GOC:hjd] +synonym: "protein trimer biosynthetic process" EXACT [GOC:hjd] +synonym: "protein trimer formation" EXACT [GOC:hjd] +is_a: GO:0051259 ! protein complex oligomerization + +[Term] +id: GO:0070207 +name: protein homotrimerization +namespace: biological_process +def: "The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits." [GOC:hjd] +synonym: "protein homotrimer assembly" EXACT [GOC:hjd] +synonym: "protein homotrimer biosynthesis" EXACT [GOC:hjd] +synonym: "protein homotrimer biosynthetic process" EXACT [GOC:hjd] +synonym: "protein homotrimer formation" EXACT [GOC:hjd] +is_a: GO:0051260 ! protein homooligomerization +is_a: GO:0070206 ! protein trimerization + +[Term] +id: GO:0070208 +name: protein heterotrimerization +namespace: biological_process +def: "The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical." [GOC:hjd] +synonym: "protein heterotrimer assembly" EXACT [GOC:hjd] +synonym: "protein heterotrimer biosynthesis" EXACT [GOC:hjd] +synonym: "protein heterotrimer biosynthetic process" EXACT [GOC:hjd] +synonym: "protein heterotrimer formation" EXACT [GOC:hjd] +is_a: GO:0051291 ! protein heterooligomerization +is_a: GO:0070206 ! protein trimerization + +[Term] +id: GO:0070209 +name: ASTRA complex +namespace: cellular_component +def: "A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p." [GOC:rb, PMID:19040720, PMID:22505622] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070210 +name: Rpd3L-Expanded complex +namespace: cellular_component +def: "A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins." [GOC:rb, PMID:19040720] +synonym: "Clr6-LE complex" EXACT [GOC:vw] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070211 +name: Snt2C complex +namespace: cellular_component +def: "A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p." [GOC:rb, PMID:19040720] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070212 +name: protein poly-ADP-ribosylation +namespace: biological_process +def: "The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain." [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379] +synonym: "addition of poly-ADP-ribose to protein" EXACT [GOC:rl] +synonym: "poly(ADP-ribose) addition to protein" EXACT [GOC:rl] +synonym: "protein amino acid poly-ADP-ribosylation" EXACT [GOC:bf] +synonym: "protein poly(ADP-ribose) metabolism" RELATED [GOC:rl] +synonym: "protein poly(ADP-ribose) synthesis" EXACT [GOC:rl] +is_a: GO:0006471 ! protein ADP-ribosylation + +[Term] +id: GO:0070213 +name: protein auto-ADP-ribosylation +namespace: biological_process +def: "The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GOC:BHF, GOC:rl] +synonym: "protein amino acid auto-ADP-ribosylation" EXACT [GOC:bf] +is_a: GO:0006471 ! protein ADP-ribosylation + +[Term] +id: GO:0070214 +name: CSK-GAP-A.p62 complex +namespace: cellular_component +def: "A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation." [PMID:7544435] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:0070215 +name: obsolete MDM2 binding +namespace: molecular_function +def: "OBSOLETE. Binding to an isoform of the MDM2 protein, a negative regulator of p53." [GOC:mah, GOC:nln] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "MDM2 binding" EXACT [] +is_obsolete: true +replaced_by: GO:0097371 + +[Term] +id: GO:0070216 +name: obsolete MDM4 binding +namespace: molecular_function +def: "OBSOLETE. Binding to an isoform of the MDM4 protein, a negative regulator of p53." [GOC:mah, GOC:nln] +comment: This term was made obsolete because it represents binding to an individual protein. +synonym: "MDM4 binding" EXACT [] +synonym: "MDMX binding" EXACT [GOC:nln] +is_obsolete: true +replaced_by: GO:0097371 + +[Term] +id: GO:0070217 +name: transcription factor TFIIIB complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex." [GOC:mah] +synonym: "TFIIIB assembly" EXACT [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0070218 +name: sulfide ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell." [GOC:mah] +synonym: "sulfide generation" RELATED [GOC:mah] +synonym: "sulfide homeostasis" EXACT [GOC:mah] +synonym: "sulfide production" RELATED [GOC:mah] +synonym: "sulphide generation" RELATED [GOC:mah] +synonym: "sulphide homeostasis" EXACT [GOC:mah] +synonym: "sulphide ion homeostasis" EXACT [GOC:mah] +synonym: "sulphide production" RELATED [GOC:mah] +is_a: GO:0055083 ! monovalent inorganic anion homeostasis +is_a: GO:0072505 ! divalent inorganic anion homeostasis + +[Term] +id: GO:0070219 +name: cellular sulfide ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell." [GOC:mah] +synonym: "cellular sulfide homeostasis" EXACT [GOC:mah] +synonym: "cellular sulphide homeostasis" EXACT [GOC:mah] +synonym: "cellular sulphide ion homeostasis" EXACT [GOC:mah] +is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis +is_a: GO:0070218 ! sulfide ion homeostasis +is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis + +[Term] +id: GO:0070220 +name: aerobic sulfur oxidation +namespace: biological_process +def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen." [MetaCyc:SULFUROX-PWY] +synonym: "aerobic sulphur oxidation" EXACT [GOC:mah] +xref: MetaCyc:SULFUROX-PWY +is_a: GO:0019417 ! sulfur oxidation + +[Term] +id: GO:0070221 +name: sulfide oxidation, using sulfide:quinone oxidoreductase +namespace: biological_process +def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase." [MetaCyc:P222-PWY] +synonym: "sulfide oxidation, using sulfide-quinone reductase" EXACT [GOC:mah, MetaCyc:P222-PWY] +synonym: "sulphide oxidation, using sulfide:quinone oxidoreductase" EXACT [GOC:mah] +xref: MetaCyc:P222-PWY +is_a: GO:0019418 ! sulfide oxidation + +[Term] +id: GO:0070222 +name: sulfide oxidation, using sulfide dehydrogenase +namespace: biological_process +def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase." [MetaCyc:PWY-5274] +synonym: "sulphide oxidation, using sulfide dehydrogenase" EXACT [GOC:mah] +xref: MetaCyc:PWY-5274 +is_a: GO:0019418 ! sulfide oxidation + +[Term] +id: GO:0070223 +name: sulfide oxidation, using sulfur dioxygenase +namespace: biological_process +def: "A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase." [MetaCyc:PWY-5285] +synonym: "sulphide oxidation, using sulfur dioxygenase" EXACT [GOC:mah] +xref: MetaCyc:PWY-5285 +is_a: GO:0019418 ! sulfide oxidation + +[Term] +id: GO:0070224 +name: sulfide:quinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN] +synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314] +synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah] +xref: MetaCyc:R17-RXN +xref: Reactome:R-HSA-1614665 "SQR oxidizes sulfide to bound persulfide" +xref: RHEA:30239 +is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0070225 +name: sulfide dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c." [RHEA:30223] +synonym: "flavocytochrome c sulfide dehydrogenase activity" EXACT [MetaCyc:RXN-8156] +synonym: "sulphide dehydrogenase activity" EXACT [GOC:mah] +xref: EC:1.8.2.3 +xref: MetaCyc:RXN-8156 +xref: RHEA:30223 +is_a: GO:0016669 ! oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor + +[Term] +id: GO:0070226 +name: sulfur:ferric ion oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+." [MetaCyc:SULFFEOXIDO-RXN] +synonym: "hydrogen sulfide:ferric ion oxidoreductase" EXACT [MetaCyc:SULFFEOXIDO-RXN] +xref: MetaCyc:SULFFEOXIDO-RXN +is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors + +[Term] +id: GO:0070227 +name: lymphocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "lymphocyte apoptosis" NARROW [] +is_a: GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:0070228 +name: regulation of lymphocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "regulation of lymphocyte apoptosis" NARROW [] +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: regulates GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0070229 +name: negative regulation of lymphocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "down regulation of lymphocyte apoptosis" EXACT [GOC:add] +synonym: "down-regulation of lymphocyte apoptosis" EXACT [GOC:add] +synonym: "downregulation of lymphocyte apoptosis" EXACT [GOC:add] +synonym: "inhibition of lymphocyte apoptosis" NARROW [GOC:add] +synonym: "negative regulation of lymphocyte apoptosis" NARROW [] +is_a: GO:0070228 ! regulation of lymphocyte apoptotic process +is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process +relationship: negatively_regulates GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0070230 +name: positive regulation of lymphocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "activation of lymphocyte apoptosis" NARROW [GOC:add] +synonym: "positive regulation of lymphocyte apoptosis" NARROW [] +synonym: "stimulation of lymphocyte apoptosis" NARROW [GOC:add] +synonym: "up regulation of lymphocyte apoptosis" EXACT [GOC:add] +synonym: "up-regulation of lymphocyte apoptosis" EXACT [GOC:add] +synonym: "upregulation of lymphocyte apoptosis" EXACT [GOC:add] +is_a: GO:0070228 ! regulation of lymphocyte apoptotic process +is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process +relationship: positively_regulates GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0070231 +name: T cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [CL:0000084, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "programmed cell death of T cells by apoptosis" EXACT [GOC:add] +synonym: "T cell apoptosis" NARROW [] +synonym: "T lymphocyte apoptosis" EXACT [GOC:add] +synonym: "T-cell apoptosis" EXACT [GOC:add] +synonym: "T-lymphocyte apoptosis" EXACT [GOC:add] +is_a: GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0070232 +name: regulation of T cell apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] +synonym: "regulation of T cell apoptosis" NARROW [] +synonym: "regulation of T lymphocyte apoptosis" EXACT [GOC:add] +synonym: "regulation of T-cell apoptosis" EXACT [GOC:add] +synonym: "regulation of T-lymphocyte apoptosis" EXACT [GOC:add] +is_a: GO:0070228 ! regulation of lymphocyte apoptotic process +relationship: regulates GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:0070233 +name: negative regulation of T cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "down regulation of T cell apoptosis" EXACT [GOC:add] +synonym: "down-regulation of T cell apoptosis" EXACT [GOC:add] +synonym: "downregulation of T cell apoptosis" EXACT [GOC:add] +synonym: "inhibition of T cell apoptosis" NARROW [GOC:add] +synonym: "negative regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] +synonym: "negative regulation of T cell apoptosis" NARROW [] +synonym: "negative regulation of T lymphocyte apoptosis" EXACT [GOC:add] +synonym: "negative regulation of T-cell apoptosis" EXACT [GOC:add] +synonym: "negative regulation of T-lymphocyte apoptosis" EXACT [GOC:add] +is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: negatively_regulates GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:0070234 +name: positive regulation of T cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "activation of T cell apoptosis" NARROW [GOC:add] +synonym: "positive regulation of programmed cell death of T cells by apoptosis" EXACT [GOC:add] +synonym: "positive regulation of T cell apoptosis" NARROW [] +synonym: "positive regulation of T lymphocyte apoptosis" EXACT [GOC:add] +synonym: "positive regulation of T-cell apoptosis" EXACT [GOC:add] +synonym: "positive regulation of T-lymphocyte apoptosis" EXACT [GOC:add] +synonym: "stimulation of T cell apoptosis" NARROW [GOC:add] +synonym: "up regulation of T cell apoptosis" EXACT [GOC:add] +synonym: "up-regulation of T cell apoptosis" EXACT [GOC:add] +synonym: "upregulation of T cell apoptosis" EXACT [GOC:add] +is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: positively_regulates GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:0070235 +name: regulation of activation-induced cell death of T cells +namespace: biological_process +def: "Any process that modulates the occurrence or rate of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] +synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] +synonym: "regulation of activation-induced cell death of T-cells" EXACT [GOC:add] +synonym: "regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] +synonym: "regulation of AICD" BROAD [GOC:add] +synonym: "regulation of antigen-driven apoptosis" BROAD [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: regulates GO:0006924 ! activation-induced cell death of T cells + +[Term] +id: GO:0070236 +name: negative regulation of activation-induced cell death of T cells +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] +synonym: "down regulation of activation-induced cell death of T cells" EXACT [GOC:add] +synonym: "down-regulation of activation-induced cell death of T cells" EXACT [GOC:add] +synonym: "downregulation of activation-induced cell death of T cells" EXACT [GOC:add] +synonym: "inhibition of activation-induced cell death of T cells" NARROW [GOC:add] +synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "negative regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] +synonym: "negative regulation of activation-induced cell death of T-cells" EXACT [GOC:add] +synonym: "negative regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] +synonym: "negative regulation of AICD" BROAD [GOC:add] +synonym: "negative regulation of antigen-driven apoptosis" BROAD [] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0070233 ! negative regulation of T cell apoptotic process +is_a: GO:0070235 ! regulation of activation-induced cell death of T cells +relationship: negatively_regulates GO:0006924 ! activation-induced cell death of T cells + +[Term] +id: GO:0070237 +name: positive regulation of activation-induced cell death of T cells +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells." [GOC:add, ISBN:0781765196] +synonym: "activation of activation-induced cell death of T cells" NARROW [GOC:add] +synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "positive regulation of activation-induced cell death of T lymphocytes" EXACT [GOC:add] +synonym: "positive regulation of activation-induced cell death of T-cells" EXACT [GOC:add] +synonym: "positive regulation of activation-induced cell death of T-lymphocytes" EXACT [GOC:add] +synonym: "positive regulation of AICD" BROAD [GOC:add] +synonym: "positive regulation of antigen-driven apoptosis" BROAD [GOC:add] +synonym: "stimulation of activation-induced cell death of T cells" NARROW [GOC:add] +synonym: "up regulation of activation-induced cell death of T cells" EXACT [GOC:add] +synonym: "up-regulation of activation-induced cell death of T cells" EXACT [GOC:add] +synonym: "upregulation of activation-induced cell death of T cells" EXACT [GOC:add] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0070234 ! positive regulation of T cell apoptotic process +is_a: GO:0070235 ! regulation of activation-induced cell death of T cells +relationship: positively_regulates GO:0006924 ! activation-induced cell death of T cells + +[Term] +id: GO:0070238 +name: activated T cell autonomous cell death +namespace: biological_process +def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "ACAD" BROAD [GOC:add] +synonym: "activated cell autonomous cell death" BROAD [GOC:add] +synonym: "activated T cell apoptosis" BROAD [GOC:add] +synonym: "activated T lymphocyte autonomous cell death" EXACT [GOC:add] +synonym: "activated T-cell autonomous cell death" EXACT [GOC:add] +synonym: "activated T-lymphocyte autonomous cell death" EXACT [GOC:add] +is_a: GO:0070231 ! T cell apoptotic process +relationship: part_of GO:0043029 ! T cell homeostasis + +[Term] +id: GO:0070239 +name: regulation of activated T cell autonomous cell death +namespace: biological_process +def: "Any process that modulates the occurrence or rate of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "regulation of ACAD" BROAD [GOC:add] +synonym: "regulation of activated cell autonomous cell death" BROAD [GOC:add] +synonym: "regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] +synonym: "regulation of activated T-cell autonomous cell death" EXACT [GOC:add] +synonym: "regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: regulates GO:0070238 ! activated T cell autonomous cell death + +[Term] +id: GO:0070240 +name: negative regulation of activated T cell autonomous cell death +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "down regulation of activated T cell autonomous cell death" EXACT [GOC:add] +synonym: "down-regulation of activated T cell autonomous cell death" EXACT [GOC:add] +synonym: "downregulation of activated T cell autonomous cell death" EXACT [GOC:add] +synonym: "inhibition of activated T cell autonomous cell death" NARROW [GOC:add] +synonym: "negative regulation of ACAD" BROAD [GOC:add] +synonym: "negative regulation of activated cell autonomous cell death" BROAD [GOC:add] +synonym: "negative regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "negative regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] +synonym: "negative regulation of activated T-cell autonomous cell death" EXACT [GOC:add] +synonym: "negative regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0070233 ! negative regulation of T cell apoptotic process +is_a: GO:0070239 ! regulation of activated T cell autonomous cell death +relationship: negatively_regulates GO:0070238 ! activated T cell autonomous cell death + +[Term] +id: GO:0070241 +name: positive regulation of activated T cell autonomous cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "activation of activated T cell autonomous cell death" NARROW [GOC:add] +synonym: "positive regulation of ACAD" BROAD [GOC:add] +synonym: "positive regulation of activated cell autonomous cell death" BROAD [GOC:add] +synonym: "positive regulation of activated T cell apoptosis" BROAD [GOC:add] +synonym: "positive regulation of activated T lymphocyte autonomous cell death" EXACT [GOC:add] +synonym: "positive regulation of activated T-cell autonomous cell death" EXACT [GOC:add] +synonym: "positive regulation of activated T-lymphocyte autonomous cell death" EXACT [GOC:add] +synonym: "stimulation of activated T cell autonomous cell death" NARROW [GOC:add] +synonym: "up regulation of activated T cell autonomous cell death" EXACT [GOC:add] +synonym: "up-regulation of activated T cell autonomous cell death" EXACT [GOC:add] +synonym: "upregulation of activated T cell autonomous cell death" EXACT [GOC:add] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0070234 ! positive regulation of T cell apoptotic process +is_a: GO:0070239 ! regulation of activated T cell autonomous cell death +relationship: positively_regulates GO:0070238 ! activated T cell autonomous cell death + +[Term] +id: GO:0070242 +name: thymocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a thymocyte, an immature T cell located in the thymus." [CL:0000893, GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). +synonym: "immature T cell apoptosis" RELATED [GOC:add] +synonym: "thymocyte apoptosis" NARROW [] +is_a: GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:0070243 +name: regulation of thymocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). +synonym: "regulation of immature T cell apoptosis" RELATED [GOC:add] +synonym: "regulation of thymocyte apoptosis" NARROW [] +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: regulates GO:0070242 ! thymocyte apoptotic process + +[Term] +id: GO:0070244 +name: negative regulation of thymocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). +synonym: "down regulation of thymocyte apoptosis" EXACT [GOC:add] +synonym: "down-regulation of thymocyte apoptosis" EXACT [GOC:add] +synonym: "downregulation of thymocyte apoptosis" EXACT [GOC:add] +synonym: "inhibition of thymocyte apoptosis" NARROW [GOC:add] +synonym: "negative regulation of immature T cell apoptosis" RELATED [GOC:add] +synonym: "negative regulation of thymocyte apoptosis" NARROW [] +is_a: GO:0070233 ! negative regulation of T cell apoptotic process +is_a: GO:0070243 ! regulation of thymocyte apoptotic process +relationship: negatively_regulates GO:0070242 ! thymocyte apoptotic process + +[Term] +id: GO:0070245 +name: positive regulation of thymocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thymocyte death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +comment: Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). +synonym: "activation of thymocyte apoptosis" NARROW [GOC:add] +synonym: "positive regulation of immature T cell apoptosis" RELATED [GOC:add] +synonym: "positive regulation of thymocyte apoptosis" NARROW [] +synonym: "stimulation of thymocyte apoptosis" NARROW [GOC:add] +synonym: "up regulation of thymocyte apoptosis" EXACT [GOC:add] +synonym: "up-regulation of thymocyte apoptosis" EXACT [GOC:add] +synonym: "upregulation of thymocyte apoptosis" EXACT [GOC:add] +is_a: GO:0070234 ! positive regulation of T cell apoptotic process +is_a: GO:0070243 ! regulation of thymocyte apoptotic process +relationship: positively_regulates GO:0070242 ! thymocyte apoptotic process + +[Term] +id: GO:0070246 +name: natural killer cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation." [CL:0000623, GOC:add, GOC:mtg_apoptosis, PMID:15728472] +synonym: "natural killer cell apoptosis" NARROW [] +synonym: "NK cell apoptosis" EXACT [GOC:add] +is_a: GO:0070227 ! lymphocyte apoptotic process + +[Term] +id: GO:0070247 +name: regulation of natural killer cell apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "regulation of natural killer cell apoptosis" NARROW [] +synonym: "regulation of NK cell apoptosis" EXACT [GOC:add] +is_a: GO:0070228 ! regulation of lymphocyte apoptotic process +relationship: regulates GO:0070246 ! natural killer cell apoptotic process + +[Term] +id: GO:0070248 +name: negative regulation of natural killer cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "down regulation of natural killer cell apoptosis" EXACT [GOC:add] +synonym: "down-regulation of natural killer cell apoptosis" EXACT [GOC:add] +synonym: "downregulation of natural killer cell apoptosis" EXACT [GOC:add] +synonym: "inhibition of natural killer cell apoptosis" NARROW [GOC:add] +synonym: "negative regulation of natural killer cell apoptosis" NARROW [] +synonym: "negative regulation of NK cell apoptosis" EXACT [GOC:add] +is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process +is_a: GO:0070247 ! regulation of natural killer cell apoptotic process +relationship: negatively_regulates GO:0070246 ! natural killer cell apoptotic process + +[Term] +id: GO:0070249 +name: positive regulation of natural killer cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell death by apoptotic process." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196] +synonym: "activation of natural killer cell apoptosis" NARROW [GOC:add] +synonym: "positive regulation of natural killer cell apoptosis" NARROW [] +synonym: "positive regulation of NK cell apoptosis" EXACT [GOC:add] +synonym: "stimulation of natural killer cell apoptosis" NARROW [GOC:add] +synonym: "up regulation of natural killer cell apoptosis" EXACT [GOC:add] +synonym: "up-regulation of natural killer cell apoptosis" EXACT [GOC:add] +synonym: "upregulation of natural killer cell apoptosis" EXACT [GOC:add] +is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process +is_a: GO:0070247 ! regulation of natural killer cell apoptotic process +relationship: positively_regulates GO:0070246 ! natural killer cell apoptotic process + +[Term] +id: GO:0070250 +name: mating projection membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone." [GOC:jp] +synonym: "shmoo membrane" NARROW [GOC:jp] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0005937 ! mating projection + +[Term] +id: GO:0070251 +name: pristanate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA." [GOC:pde, PMID:10198260] +synonym: "pristanate:CoA ligase (AMP-forming)" EXACT [GOC:mah] +synonym: "pristanoyl-CoA ligase activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-389632 "pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate" +xref: RHEA:47264 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0070252 +name: actin-mediated cell contraction +namespace: biological_process +def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body." [GOC:mah] +is_a: GO:0030048 ! actin filament-based movement + +[Term] +id: GO:0070253 +name: somatostatin secretion +namespace: biological_process +def: "The regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:mah] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0070254 +name: mucus secretion +namespace: biological_process +def: "The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function." [GOC:add, ISBN:068340007X, ISBN:0721662544] +synonym: "mucus production" EXACT [GOC:add] +is_a: GO:0007589 ! body fluid secretion +is_a: GO:0032941 ! secretion by tissue + +[Term] +id: GO:0070255 +name: regulation of mucus secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "regulation of mucus production" EXACT [GOC:add] +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0070254 ! mucus secretion + +[Term] +id: GO:0070256 +name: negative regulation of mucus secretion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "negative regulation of mucus production" EXACT [GOC:add] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070255 ! regulation of mucus secretion +relationship: negatively_regulates GO:0070254 ! mucus secretion + +[Term] +id: GO:0070257 +name: positive regulation of mucus secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue." [GOC:add] +synonym: "positive regulation of mucus production" EXACT [GOC:add] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070255 ! regulation of mucus secretion +relationship: positively_regulates GO:0070254 ! mucus secretion + +[Term] +id: GO:0070258 +name: inner membrane pellicle complex +namespace: cellular_component +def: "A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell." [GOC:mah, PMID:12456714] +synonym: "inner membrane complex" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020039 ! pellicle + +[Term] +id: GO:0070259 +name: tyrosyl-DNA phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA." [GOC:elh, PMID:16751265] +comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0070260 +name: 5'-tyrosyl-DNA phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA." [PMID:16751265] +comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. +is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity + +[Term] +id: GO:0070262 +name: peptidyl-serine dephosphorylation +namespace: biological_process +def: "The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine." [GOC:bf] +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0070263 +name: external side of fungal-type cell wall +namespace: cellular_component +def: "The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents." [GOC:mah] +is_a: GO:0010339 ! external side of cell wall +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0070264 +name: transcription factor TFIIIE complex +namespace: cellular_component +def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins." [GOC:jp, PMID:19116144] +is_a: GO:0090576 ! RNA polymerase III transcription regulator complex + +[Term] +id: GO:0070265 +name: necrotic cell death +namespace: biological_process +def: "A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910] +comment: Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'. +synonym: "cellular necrosis" EXACT [GOC:add] +synonym: "necrosis" BROAD [GOC:mah] +is_a: GO:0008219 ! cell death + +[Term] +id: GO:0070266 +name: necroptotic process +namespace: biological_process +alt_id: GO:0060553 +alt_id: GO:0060554 +alt_id: GO:0060555 +def: "A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former." [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] +comment: Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097. +synonym: "activation of necroptosis" RELATED [] +synonym: "activation of necroptosis by extracellular signals" RELATED [] +synonym: "activation of necroptosis in response to extracellular signals" RELATED [] +synonym: "activation of necroptosis of activated-T cells" RELATED [] +synonym: "establishment of necroptosis" RELATED [] +synonym: "establishment of necroptosis of activated-T cells" RELATED [] +synonym: "extracellular signal-induced necroptosis" RELATED [] +synonym: "induction of necroptosis" BROAD [] +synonym: "induction of necroptosis by extracellular signals" BROAD [] +synonym: "induction of necroptosis of activated-T cells" BROAD [] +synonym: "necroptosis" NARROW [] +synonym: "PARP-dependent cell death" RELATED [] +synonym: "parthanatos" RELATED [] +synonym: "programmed necrosis" BROAD [Reactome:R-HSA-5213460.1] +synonym: "programmed necrotic cell death" BROAD [GOC:mah] +synonym: "RIPK1-mediated regulated necrosis" EXACT [Reactome:R-HSA-5213460.1] +synonym: "TNF-induced necroptosis" NARROW [PMID:21876153] +is_a: GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:0070267 +name: oncosis +namespace: biological_process +def: "A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death." [PMID:17873035, PMID:18846107] +comment: Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death. +is_a: GO:0045793 ! positive regulation of cell size +relationship: part_of GO:0070265 ! necrotic cell death + +[Term] +id: GO:0070268 +name: cornification +namespace: biological_process +def: "A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." [GOC:krc, PMID:18846107] +is_a: GO:0012501 ! programmed cell death +relationship: part_of GO:0031424 ! keratinization + +[Term] +id: GO:0070269 +name: pyroptosis +namespace: biological_process +def: "A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18." [GOC:mtg_apoptosis, PMID:18846107, PMID:21760595] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0070270 +name: obsolete mitotic catastrophe +namespace: biological_process +def: "OBSOLETE. A type of programmed cell death that occurs during or shortly after a dysregulated or failed mitosis and can be accompanied by morphological alterations including micronucleation and multinucleation." [PMID:18846107] +comment: This term was made obsolete because it does not refer to a true process, but rather to the consequences of aberrations occurred during mitosis. +synonym: "cell death occurring during metaphase" RELATED [PMID:18846107] +synonym: "cell death preceded by multinucleation" RELATED [PMID:18846107] +synonym: "mitotic catastrophe" EXACT [] +is_obsolete: true + +[Term] +id: GO:0070271 +name: obsolete protein complex biogenesis +namespace: biological_process +def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah] +synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0070272 +name: obsolete proton-transporting ATP synthase complex biogenesis +namespace: biological_process +def: "OBSOLETE. The biogenesis of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mah, PMID:19103153] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +synonym: "F-type ATPase complex biogenesis" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0070273 +name: phosphatidylinositol-4-phosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position." [GOC:bf, GOC:mah] +is_a: GO:1901981 ! phosphatidylinositol phosphate binding + +[Term] +id: GO:0070274 +name: RES complex +namespace: cellular_component +def: "A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p." [PMID:15565172, PMID:18809678, PMID:19010333, PMID:19033360] +synonym: "pre-mRNA retention and splicing complex" EXACT [GOC:sre] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070275 +name: aerobic ammonia oxidation to nitrite via pyruvic oxime +namespace: biological_process +def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite." [MetaCyc:PWY-2242] +xref: MetaCyc:PWY-2242 +is_a: GO:0019329 ! ammonia oxidation + +[Term] +id: GO:0070276 +name: halogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds." [GOC:mah] +synonym: "halogen metabolism" EXACT [] +is_a: GO:0044281 ! small molecule metabolic process + +[Term] +id: GO:0070277 +name: iodide oxidation +namespace: biological_process +def: "The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons." [GOC:mah, MetaCyc:IODIDE-PEROXIDASE-RXN] +is_a: GO:0070276 ! halogen metabolic process + +[Term] +id: GO:0070278 +name: extracellular matrix constituent secretion +namespace: biological_process +def: "The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell." [GOC:mah] +synonym: "ECM constituent secretion" EXACT [GOC:mah] +synonym: "ECM secretion" EXACT [GOC:mah] +is_a: GO:0032940 ! secretion by cell +relationship: part_of GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0070279 +name: vitamin B6 binding +namespace: molecular_function +def: "Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate." [GOC:mah] +is_a: GO:0019842 ! vitamin binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0070280 +name: pyridoxal binding +namespace: molecular_function +def: "Binding to pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde, a form of vitamin B6." [CHEBI:17310, GOC:mah] +is_a: GO:0043169 ! cation binding +is_a: GO:0070279 ! vitamin B6 binding + +[Term] +id: GO:0070281 +name: pyridoxamine binding +namespace: molecular_function +def: "Binding to pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16410, GOC:mah] +is_a: GO:0043169 ! cation binding +is_a: GO:0070279 ! vitamin B6 binding + +[Term] +id: GO:0070282 +name: pyridoxine binding +namespace: molecular_function +def: "Binding to pyridoxine, 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol, a form of vitamin B6." [CHEBI:16709, GOC:mah] +is_a: GO:0070279 ! vitamin B6 binding + +[Term] +id: GO:0070284 +name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine." [PMID:18953358] +synonym: "HMP-P synthase activity" EXACT [PMID:18953358] +synonym: "ThiC" RELATED [PMID:18953358] +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0070285 +name: pigment cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate." [GOC:cvs] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0050931 ! pigment cell differentiation + +[Term] +id: GO:0070286 +name: axonemal dynein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:mah, PMID:19052621] +synonym: "dynein arm assembly" EXACT [GOC:vk, PMID:19944405] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0035082 ! axoneme assembly + +[Term] +id: GO:0070287 +name: ferritin receptor activity +namespace: molecular_function +def: "Combining with ferritin, and delivering ferritin into the cell via endocytosis." [GOC:bf, PMID:17459943, PMID:19154717] +synonym: "ferritin complex receptor activity" EXACT [GOC:mah] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0070288 +name: ferritin complex +namespace: cellular_component +def: "A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain." [GOC:mah, PMID:19154717] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0070289 +name: extracellular ferritin complex +namespace: cellular_component +def: "A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains." [GOC:mah, PMID:19154717] +synonym: "serum ferritin complex" RELATED [PMID:19154717] +is_a: GO:0070288 ! ferritin complex +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0070290 +name: N-acylphosphatidylethanolamine-specific phospholipase D activity +namespace: molecular_function +def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693] +subset: goslim_chembl +synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT [] +synonym: "NAPE-specific phospholipase D activity" EXACT [] +xref: EC:3.1.4.4 +xref: Reactome:R-HSA-2466831 "A2PE hydrolyses to A2E" +is_a: GO:0004620 ! phospholipase activity +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0070291 +name: N-acylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group." [CHEBI:52640, GOC:elh, PMID:14634025, PMID:15878693] +synonym: "N-acylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +synonym: "NAE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +synonym: "NAE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042439 ! ethanolamine-containing compound metabolic process + +[Term] +id: GO:0070292 +name: N-acylphosphatidylethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group." [GOC:elh, GOC:mah, PMID:14634025, PMID:15878693] +synonym: "N-acylphosphatidylethanolamine metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +synonym: "NAPE metabolic process" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +synonym: "NAPE metabolism" EXACT [GOC:elh, PMID:14634025, PMID:15878693] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046337 ! phosphatidylethanolamine metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0070293 +name: renal absorption +namespace: biological_process +def: "A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:dph, GOC:mah, GOC:yaf] +synonym: "nephron absorption" EXACT [GOC:mah] +synonym: "renal reabsorption" EXACT [GOC:dph] +is_a: GO:0003014 ! renal system process + +[Term] +id: GO:0070294 +name: renal sodium ion absorption +namespace: biological_process +def: "A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah] +synonym: "nephron sodium ion absorption" EXACT [GOC:mah] +synonym: "renal sodium ion reabsorption" EXACT [GOC:dph] +is_a: GO:0003096 ! renal sodium ion transport +is_a: GO:0070293 ! renal absorption + +[Term] +id: GO:0070295 +name: renal water absorption +namespace: biological_process +def: "A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:dph, GOC:mah] +synonym: "nephron water absorption" EXACT [GOC:mah] +synonym: "renal water reabsorption" EXACT [GOC:dph] +is_a: GO:0003097 ! renal water transport +is_a: GO:0070293 ! renal absorption + +[Term] +id: GO:0070296 +name: sarcoplasmic reticulum calcium ion transport +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) into, out of or within the sarcoplasmic reticulum." [GOC:BHF, GOC:vk] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0070297 +name: regulation of phosphorelay signal transduction system +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] +synonym: "regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] +synonym: "regulation of two-component signal transduction system" EXACT [GOC:bf, GOC:mah] +synonym: "regulation of two-component signal transduction system (phosphorelay)" NARROW [] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0000160 ! phosphorelay signal transduction system + +[Term] +id: GO:0070298 +name: negative regulation of phosphorelay signal transduction system +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] +synonym: "down regulation of two-component signal transduction" EXACT [GOC:mah] +synonym: "down-regulation of two-component signal transduction" EXACT [GOC:mah] +synonym: "downregulation of two-component signal transduction" EXACT [GOC:mah] +synonym: "inhibition of two-component signal transduction" NARROW [GOC:mah] +synonym: "negative regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] +synonym: "negative regulation of two-component signal transduction system (phosphorelay)" NARROW [] +is_a: GO:0070297 ! regulation of phosphorelay signal transduction system +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0000160 ! phosphorelay signal transduction system + +[Term] +id: GO:0070299 +name: positive regulation of phosphorelay signal transduction system +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." [GOC:mah] +synonym: "activation of two-component signal transduction" NARROW [GOC:mah] +synonym: "positive regulation of histidyl-aspartyl phosphorelay" EXACT [GOC:mah] +synonym: "positive regulation of two-component signal transduction system (phosphorelay)" NARROW [] +synonym: "stimulation of two-component signal transduction" NARROW [GOC:mah] +synonym: "up regulation of two-component signal transduction" EXACT [GOC:mah] +synonym: "up-regulation of two-component signal transduction" EXACT [GOC:mah] +synonym: "upregulation of two-component signal transduction" EXACT [GOC:mah] +is_a: GO:0070297 ! regulation of phosphorelay signal transduction system +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0000160 ! phosphorelay signal transduction system + +[Term] +id: GO:0070300 +name: phosphatidic acid binding +namespace: molecular_function +def: "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [CHEBI:16337, GOC:jp, ISBN:0198506732] +synonym: "phosphatidate binding" EXACT [GOC:jp] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0070301 +name: cellular response to hydrogen peroxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah] +is_a: GO:0034614 ! cellular response to reactive oxygen species +is_a: GO:0042542 ! response to hydrogen peroxide + +[Term] +id: GO:0070302 +name: regulation of stress-activated protein kinase signaling cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade." [GOC:mah] +synonym: "regulation of SAPK signaling pathway" EXACT [GOC:mah] +synonym: "regulation of stress-activated protein kinase signaling pathway" EXACT [] +synonym: "regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0080135 ! regulation of cellular response to stress +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0031098 ! stress-activated protein kinase signaling cascade + +[Term] +id: GO:0070303 +name: negative regulation of stress-activated protein kinase signaling cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] +synonym: "down regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +synonym: "down-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +synonym: "downregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +synonym: "inhibition of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] +synonym: "negative regulation of SAPK signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of stress-activated protein kinase signaling pathway" EXACT [] +synonym: "negative regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade + +[Term] +id: GO:0070304 +name: positive regulation of stress-activated protein kinase signaling cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade." [GOC:mah] +synonym: "activation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] +synonym: "positive regulation of SAPK signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of stress-activated protein kinase signaling pathway" EXACT [] +synonym: "positive regulation of stress-activated protein kinase signalling pathway" EXACT [GOC:mah] +synonym: "stimulation of stress-activated protein kinase signaling pathway" NARROW [GOC:mah] +synonym: "up regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +synonym: "up-regulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +synonym: "upregulation of stress-activated protein kinase signaling pathway" EXACT [GOC:mah] +is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0031098 ! stress-activated protein kinase signaling cascade + +[Term] +id: GO:0070305 +name: response to cGMP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:sl] +synonym: "response to 3',5' cGMP" EXACT [GOC:mah] +synonym: "response to 3',5'-cGMP" EXACT [GOC:mah] +synonym: "response to cyclic GMP" EXACT [GOC:mah] +synonym: "response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0070306 +name: lens fiber cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities." [GOC:mah, PMID:7693735] +synonym: "lens fibre cell differentiation" EXACT [GOC:mah] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0002088 ! lens development in camera-type eye + +[Term] +id: GO:0070307 +name: lens fiber cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] +synonym: "lens fibre cell development" EXACT [GOC:mah] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0070306 ! lens fiber cell differentiation + +[Term] +id: GO:0070308 +name: lens fiber cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] +synonym: "lens fibre cell fate commitment" EXACT [GOC:mah] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0070306 ! lens fiber cell differentiation + +[Term] +id: GO:0070309 +name: lens fiber cell morphogenesis +namespace: biological_process +def: "The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [GOC:mah, PMID:7693735] +synonym: "elongation of lens fiber cell" NARROW [GOC:mah, GOC:vk] +synonym: "lens fiber cell morphogenesis during differentiation" EXACT systematic_synonym [GOC:mah] +synonym: "lens fibre cell morphogenesis" EXACT [GOC:mah] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0002089 ! lens morphogenesis in camera-type eye +relationship: part_of GO:0070307 ! lens fiber cell development + +[Term] +id: GO:0070310 +name: ATR-ATRIP complex +namespace: cellular_component +def: "A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A." [GOC:mah, PMID:14724280] +synonym: "Mec1-Lcd1 complex" NARROW [PMID:17339343] +synonym: "Rad3-Rad26 complex" NARROW [PMID:17339343] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070311 +name: nucleosomal methylation activator complex +namespace: cellular_component +def: "A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription." [GOC:mah, PMID:14729568] +synonym: "NUMAC" EXACT [PMID:14729568] +is_a: GO:0035097 ! histone methyltransferase complex + +[Term] +id: GO:0070312 +name: RAD52-ERCC4-ERCC1 complex +namespace: cellular_component +def: "A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein." [PMID:14734547] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0070313 +name: RGS6-DNMT1-DMAP1 complex +namespace: cellular_component +def: "A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1." [GOC:mah, PMID:14734556] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070314 +name: G1 to G0 transition +namespace: biological_process +def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194] +synonym: "cell cycle quiescence" RELATED [GOC:mah] +synonym: "establishment of cell quiescence" EXACT [GOC:mah] +synonym: "G1/G0 transition" EXACT [GOC:mah] +synonym: "stationary phase" RELATED [GOC:mah] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0070315 +name: G1 to G0 transition involved in cell differentiation +namespace: biological_process +def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation." [GOC:mah, ISBN:0815316194] +synonym: "G1/G0 transition involved in cell differentiation" EXACT [GOC:mah] +is_a: GO:0070314 ! G1 to G0 transition +relationship: part_of GO:0030154 ! cell differentiation + +[Term] +id: GO:0070316 +name: regulation of G0 to G1 transition +namespace: biological_process +def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0045023 ! G0 to G1 transition + +[Term] +id: GO:0070317 +name: negative regulation of G0 to G1 transition +namespace: biological_process +def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] +synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah] +synonym: "maintenance of cell quiescence" EXACT [GOC:mah] +synonym: "maintenance of G0 arrest" EXACT [GOC:mah] +synonym: "maintenance of G0 phase" EXACT [GOC:mah] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0070316 ! regulation of G0 to G1 transition +relationship: negatively_regulates GO:0045023 ! G0 to G1 transition + +[Term] +id: GO:0070318 +name: positive regulation of G0 to G1 transition +namespace: biological_process +def: "A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] +is_a: GO:0070316 ! regulation of G0 to G1 transition +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0045023 ! G0 to G1 transition + +[Term] +id: GO:0070319 +name: Golgi to plasma membrane transport vesicle +namespace: cellular_component +def: "A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] +synonym: "Golgi to plasma membrane constitutive secretory pathway transport vesicle" EXACT [] +synonym: "Golgi-plasma membrane transport vesicle" EXACT [GOC:mah] +is_a: GO:0070382 ! exocytic vesicle + +[Term] +id: GO:0070320 +name: inward rectifier potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an inwardly rectifying potassium channel." [GOC:mah] +is_a: GO:0019870 ! potassium channel inhibitor activity + +[Term] +id: GO:0070321 +name: obsolete regulation of translation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] +comment: This term was obsoleted because it was redundant with GO:1903832 ; regulation of cellular response to amino acid starvation. +is_obsolete: true +consider: GO:1903832 + +[Term] +id: GO:0070322 +name: obsolete negative regulation of translation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] +comment: This term was obsoleted because it was redundant with GO:1903574 ; negative regulation of cellular response to amino acid starvation. +synonym: "down regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +synonym: "down-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +synonym: "downregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +synonym: "inhibition of translation in response to nitrogen starvation" NARROW [GOC:mah] +is_obsolete: true +consider: GO:1903574 + +[Term] +id: GO:0070323 +name: obsolete positive regulation of translation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] +comment: This term was obsoleted because it was redundant with GO:1903833 ; positive regulation of cellular response to amino acid starvation. +synonym: "activation of translation in response to nitrogen starvation" NARROW [GOC:mah] +synonym: "stimulation of translation in response to nitrogen starvation" NARROW [GOC:mah] +synonym: "up regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +synonym: "up-regulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +synonym: "upregulation of translation in response to nitrogen starvation" EXACT [GOC:mah] +is_obsolete: true +consider: GO:1903833 + +[Term] +id: GO:0070324 +name: thyroid hormone binding +namespace: molecular_function +def: "Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph] +subset: goslim_chembl +synonym: "thyroxine binding" NARROW [GOC:mah] +synonym: "triiodothyronine binding" NARROW [GOC:mah] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0070325 +name: lipoprotein particle receptor binding +namespace: molecular_function +def: "Binding to a lipoprotein particle receptor." [GOC:BHF, GOC:rl] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0070326 +name: very-low-density lipoprotein particle receptor binding +namespace: molecular_function +def: "Binding to a very-low-density lipoprotein receptor." [GOC:BHF, GOC:mah] +synonym: "apolipoprotein E receptor binding" RELATED [GOC:rl] +synonym: "very-low-density lipoprotein receptor binding" EXACT [GOC:bf, GOC:dph] +synonym: "VLDL receptor binding" EXACT [GOC:mah] +synonym: "VLDLR binding" EXACT [GOC:mah] +is_a: GO:0070325 ! lipoprotein particle receptor binding + +[Term] +id: GO:0070327 +name: thyroid hormone transport +namespace: biological_process +def: "The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:rph] +synonym: "thyroxine transport" NARROW [GOC:mah] +synonym: "triiodothyronine transport" NARROW [GOC:mah] +is_a: GO:0009914 ! hormone transport + +[Term] +id: GO:0070328 +name: triglyceride homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell." [GOC:BHF, GOC:mah] +synonym: "triacylglycerol homeostasis" EXACT [GOC:rl] +is_a: GO:0055090 ! acylglycerol homeostasis + +[Term] +id: GO:0070329 +name: tRNA seleno-modification +namespace: biological_process +def: "The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule." [GOC:jsg, PMID:14594807] +synonym: "tRNA base modification to selenouridine" EXACT [GOC:mah] +is_a: GO:0001887 ! selenium compound metabolic process +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0070330 +name: aromatase activity +namespace: molecular_function +def: "Catalysis of the reduction of an aliphatic ring to yield an aromatic ring." [GOC:cb] +synonym: "estrogen synthetase activity" NARROW [] +xref: EC:1.14.14.1 +xref: MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN +xref: RHEA:17149 +xref: UM-BBD_enzymeID:e0551 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0070331 +name: CD20-Lck-Fyn complex +namespace: cellular_component +def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn." [GOC:mah, PMID:7545683] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0070332 +name: CD20-Lck-Lyn-Fyn complex +namespace: cellular_component +def: "A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn." [GOC:mah, PMID:7545683] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0070333 +name: alpha6-beta4 integrin-Shc-Grb2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2." [PMID:7556090] +synonym: "ITGA6-ITGB4-SHC-GRB2 complex" NARROW [CORUM:3096] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070334 +name: alpha6-beta4 integrin-laminin 5 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5." [GOC:mah, PMID:7556090] +synonym: "alpha6-beta4 integrin-laminin-332 complex" EXACT [GOC:sl, PMID:15979864] +synonym: "ITGA6-ITGB4-LAMA5 complex" NARROW [CORUM:2322] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070335 +name: aspartate binding +namespace: molecular_function +def: "Binding to aspartate, the alpha-amino-acid anion of 2-aminobutanedioic acid that has formula C4H5NO4." [CHEBI:29995, GOC:mah] +synonym: "aspartic acid binding" EXACT [GOC:mah] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0070336 +name: flap-structured DNA binding +namespace: molecular_function +def: "Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0070337 +name: 3'-flap-structured DNA binding +namespace: molecular_function +def: "Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule." [GOC:mah, PMID:15189154] +is_a: GO:0070336 ! flap-structured DNA binding + +[Term] +id: GO:0070338 +name: 5'-flap-structured DNA binding +namespace: molecular_function +def: "Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers." [GOC:mah, PMID:15189154] +is_a: GO:0070336 ! flap-structured DNA binding + +[Term] +id: GO:0070339 +name: response to bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:add, PMID:12077222] +is_a: GO:0032493 ! response to bacterial lipoprotein + +[Term] +id: GO:0070340 +name: detection of bacterial lipopeptide +namespace: biological_process +def: "The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal." [GOC:add, PMID:12077222] +is_a: GO:0042494 ! detection of bacterial lipoprotein +is_a: GO:0070339 ! response to bacterial lipopeptide + +[Term] +id: GO:0070341 +name: fat cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat." [GOC:mah, GOC:sl] +synonym: "adipocyte proliferation" EXACT [GOC:sl] +synonym: "adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0070342 +name: brown fat cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species." [CL:0000449, GOC:mah, GOC:sl] +synonym: "brown adipocyte proliferation" EXACT [GOC:sl] +synonym: "brown adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070341 ! fat cell proliferation + +[Term] +id: GO:0070343 +name: white fat cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population." [CL:0000448, GOC:mah, GOC:sl] +synonym: "white adipocyte proliferation" EXACT [GOC:sl] +synonym: "white adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070341 ! fat cell proliferation + +[Term] +id: GO:0070344 +name: regulation of fat cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "regulation of adipocyte proliferation" EXACT [GOC:sl] +synonym: "regulation of adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0070341 ! fat cell proliferation + +[Term] +id: GO:0070345 +name: negative regulation of fat cell proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "down regulation of fat cell proliferation" EXACT [GOC:mah] +synonym: "down-regulation of fat cell proliferation" EXACT [GOC:mah] +synonym: "downregulation of fat cell proliferation" EXACT [GOC:mah] +synonym: "inhibition of fat cell proliferation" NARROW [GOC:mah] +synonym: "negative regulation of adipocyte proliferation" EXACT [GOC:sl] +synonym: "negative regulation of adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0070344 ! regulation of fat cell proliferation +relationship: negatively_regulates GO:0070341 ! fat cell proliferation + +[Term] +id: GO:0070346 +name: positive regulation of fat cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "activation of fat cell proliferation" NARROW [GOC:mah] +synonym: "positive regulation of adipocyte proliferation" EXACT [GOC:sl] +synonym: "positive regulation of adipose cell proliferation" EXACT [GOC:sl] +synonym: "stimulation of fat cell proliferation" NARROW [GOC:mah] +synonym: "up regulation of fat cell proliferation" EXACT [GOC:mah] +synonym: "up-regulation of fat cell proliferation" EXACT [GOC:mah] +synonym: "upregulation of fat cell proliferation" EXACT [GOC:mah] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0070344 ! regulation of fat cell proliferation +relationship: positively_regulates GO:0070341 ! fat cell proliferation + +[Term] +id: GO:0070347 +name: regulation of brown fat cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "regulation of brown adipocyte proliferation" EXACT [GOC:sl] +synonym: "regulation of brown adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070344 ! regulation of fat cell proliferation +relationship: regulates GO:0070342 ! brown fat cell proliferation + +[Term] +id: GO:0070348 +name: negative regulation of brown fat cell proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "down regulation of brown fat cell proliferation" EXACT [GOC:mah] +synonym: "down-regulation of brown fat cell proliferation" EXACT [GOC:mah] +synonym: "downregulation of brown fat cell proliferation" EXACT [GOC:mah] +synonym: "inhibition of brown fat cell proliferation" NARROW [GOC:mah] +synonym: "negative regulation of brown adipocyte proliferation" EXACT [GOC:sl] +synonym: "negative regulation of brown adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070345 ! negative regulation of fat cell proliferation +is_a: GO:0070347 ! regulation of brown fat cell proliferation +relationship: negatively_regulates GO:0070342 ! brown fat cell proliferation + +[Term] +id: GO:0070349 +name: positive regulation of brown fat cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of brown fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "activation of brown fat cell proliferation" NARROW [GOC:mah] +synonym: "positive regulation of brown adipocyte proliferation" EXACT [GOC:sl] +synonym: "positive regulation of brown adipose cell proliferation" EXACT [GOC:sl] +synonym: "stimulation of brown fat cell proliferation" NARROW [GOC:mah] +synonym: "up regulation of brown fat cell proliferation" EXACT [GOC:mah] +synonym: "up-regulation of brown fat cell proliferation" EXACT [GOC:mah] +synonym: "upregulation of brown fat cell proliferation" EXACT [GOC:mah] +is_a: GO:0070346 ! positive regulation of fat cell proliferation +is_a: GO:0070347 ! regulation of brown fat cell proliferation +relationship: positively_regulates GO:0070342 ! brown fat cell proliferation + +[Term] +id: GO:0070350 +name: regulation of white fat cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "regulation of white adipocyte proliferation" EXACT [GOC:sl] +synonym: "regulation of white adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070344 ! regulation of fat cell proliferation +relationship: regulates GO:0070343 ! white fat cell proliferation + +[Term] +id: GO:0070351 +name: negative regulation of white fat cell proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "down regulation of white fat cell proliferation" EXACT [GOC:mah] +synonym: "down-regulation of white fat cell proliferation" EXACT [GOC:mah] +synonym: "downregulation of white fat cell proliferation" EXACT [GOC:mah] +synonym: "inhibition of white fat cell proliferation" NARROW [GOC:mah] +synonym: "negative regulation of white adipocyte proliferation" EXACT [GOC:sl] +synonym: "negative regulation of white adipose cell proliferation" EXACT [GOC:sl] +is_a: GO:0070345 ! negative regulation of fat cell proliferation +is_a: GO:0070350 ! regulation of white fat cell proliferation +relationship: negatively_regulates GO:0070343 ! white fat cell proliferation + +[Term] +id: GO:0070352 +name: positive regulation of white fat cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of white fat cell proliferation." [GOC:mah, GOC:sl] +synonym: "activation of white fat cell proliferation" NARROW [GOC:mah] +synonym: "positive regulation of white adipocyte proliferation" EXACT [GOC:sl] +synonym: "positive regulation of white adipose cell proliferation" EXACT [GOC:sl] +synonym: "stimulation of white fat cell proliferation" NARROW [GOC:mah] +synonym: "up regulation of white fat cell proliferation" EXACT [GOC:mah] +synonym: "up-regulation of white fat cell proliferation" EXACT [GOC:mah] +synonym: "upregulation of white fat cell proliferation" EXACT [GOC:mah] +is_a: GO:0070346 ! positive regulation of fat cell proliferation +is_a: GO:0070350 ! regulation of white fat cell proliferation +relationship: positively_regulates GO:0070343 ! white fat cell proliferation + +[Term] +id: GO:0070353 +name: GATA1-TAL1-TCF3-Lmo2 complex +namespace: cellular_component +def: "A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070354 +name: GATA2-TAL1-TCF3-Lmo2 complex +namespace: cellular_component +def: "A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis." [PMID:7568177] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070355 +name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex +namespace: cellular_component +def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof)." [PMID:7654227] +synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2)" NARROW [CORUM:1247] +synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex" NARROW [CORUM:1247] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070356 +name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex +namespace: cellular_component +def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof)." [PMID:7654227] +synonym: "SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)" NARROW [CORUM:1244] +synonym: "STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex" NARROW [CORUM:1244] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070357 +name: alphav-beta3 integrin-CD47 complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP)." [PMID:2277087, PMID:7691831] +synonym: "ITGB3-ITGAV-CD47 complex" NARROW [CORUM:2356] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070358 +name: actin polymerization-dependent cell motility +namespace: biological_process +def: "A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell." [GOC:mah, PMID:15773977] +synonym: "cell motility by actin tail formation" EXACT [PMID:15773977] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0070359 +name: actin polymerization-dependent cell motility involved in migration of symbiont in host +namespace: biological_process +def: "A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell." [GOC:jl, GOC:mah, PMID:15773977] +synonym: "actin polymerization-dependent cell motility involved in migration of symbiont within host" EXACT [] +is_a: GO:0070358 ! actin polymerization-dependent cell motility +relationship: part_of GO:0070360 ! migration of symbiont within host by polymerization of host actin + +[Term] +id: GO:0070360 +name: migration of symbiont within host by polymerization of host actin +namespace: biological_process +def: "The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:mah] +is_a: GO:0044001 ! migration in host + +[Term] +id: GO:0070365 +name: hepatocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." [CL:0000182, PMID:7588884] +synonym: "liver cell differentiation" EXACT [GOC:mah] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0070366 +name: regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "regulation of liver cell differentiation" EXACT [GOC:sl] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0070365 ! hepatocyte differentiation + +[Term] +id: GO:0070367 +name: negative regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "down regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "down-regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "downregulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "inhibition of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "negative regulation of liver cell differentiation" EXACT [GOC:sl] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0070366 ! regulation of hepatocyte differentiation +relationship: negatively_regulates GO:0070365 ! hepatocyte differentiation + +[Term] +id: GO:0070368 +name: positive regulation of hepatocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of hepatocyte differentiation." [GOC:mah, GOC:sl] +synonym: "activation of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "positive regulation of liver cell differentiation" EXACT [GOC:sl] +synonym: "stimulation of hepatocyte differentiation" NARROW [GOC:mah] +synonym: "up regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "up-regulation of hepatocyte differentiation" EXACT [GOC:mah] +synonym: "upregulation of hepatocyte differentiation" EXACT [GOC:mah] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0070366 ! regulation of hepatocyte differentiation +relationship: positively_regulates GO:0070365 ! hepatocyte differentiation + +[Term] +id: GO:0070369 +name: beta-catenin-TCF7L2 complex +namespace: cellular_component +def: "A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, PMID:9065401, PMID:9065402] +synonym: "beta-catenin-TCF4 complex" EXACT [PMID:9065401, PMID:9065402] +is_a: GO:0071664 ! catenin-TCF7L2 complex +is_a: GO:1990907 ! beta-catenin-TCF complex + +[Term] +id: GO:0070370 +name: cellular heat acclimation +namespace: biological_process +def: "Any process that increases heat tolerance of a cell in response to high temperatures." [GOC:jp] +synonym: "cellular thermotolerance" EXACT [GOC:jp] +is_a: GO:0010286 ! heat acclimation +is_a: GO:0034605 ! cellular response to heat + +[Term] +id: GO:0070371 +name: ERK1 and ERK2 cascade +namespace: biological_process +def: "An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0121245462, ISBN:0896039986, PMID:20811974, PMID:28903453] +comment: Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases. +synonym: "ERK cascade" BROAD [GOC:add] +synonym: "ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] +synonym: "ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] +synonym: "ERK1 cascade" NARROW [GOC:add] +synonym: "ERK1/2 cascade" EXACT [GOC:add] +synonym: "ERK2 cascade" NARROW [GOC:add] +synonym: "extracellular signal-regulated kinase 1/2 (ERK1/2) cascade" EXACT [PMID:20811974] +synonym: "extracellular signal-regulated kinase 1/2 cascade" EXACT [PMID:20811974] +synonym: "MAPK1 cascade" NARROW [GOC:add] +synonym: "MAPK3 cascade" NARROW [GOC:add] +is_a: GO:0000165 ! MAPK cascade + +[Term] +id: GO:0070372 +name: regulation of ERK1 and ERK2 cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] +synonym: "regulation of ERK cascade" BROAD [GOC:add] +synonym: "regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] +synonym: "regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] +synonym: "regulation of ERK1 cascade" NARROW [GOC:add] +synonym: "regulation of ERK1/2 cascade" EXACT [GOC:add] +synonym: "regulation of ERK2 cascade" NARROW [GOC:add] +synonym: "regulation of MAPK1 cascade" NARROW [GOC:add] +synonym: "regulation of MAPK3 cascade" NARROW [GOC:add] +is_a: GO:0043408 ! regulation of MAPK cascade +relationship: regulates GO:0070371 ! ERK1 and ERK2 cascade + +[Term] +id: GO:0070373 +name: negative regulation of ERK1 and ERK2 cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] +synonym: "down regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +synonym: "down-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +synonym: "downregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +synonym: "inhibition of ERK1 and ERK2 cascade" NARROW [GOC:mah] +synonym: "negative regulation of ERK cascade" BROAD [GOC:add] +synonym: "negative regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of ERK1 cascade" NARROW [GOC:add] +synonym: "negative regulation of ERK1/2 cascade" EXACT [GOC:add] +synonym: "negative regulation of ERK2 cascade" NARROW [GOC:add] +synonym: "negative regulation of MAPK1 cascade" NARROW [GOC:add] +synonym: "negative regulation of MAPK3 cascade" NARROW [GOC:add] +is_a: GO:0043409 ! negative regulation of MAPK cascade +is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade +relationship: negatively_regulates GO:0070371 ! ERK1 and ERK2 cascade + +[Term] +id: GO:0070374 +name: positive regulation of ERK1 and ERK2 cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade." [GOC:mah] +synonym: "activation of ERK1 and ERK2 cascade" NARROW [GOC:mah] +synonym: "positive regulation of ERK cascade" BROAD [GOC:add] +synonym: "positive regulation of ERK1 and ERK2 signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of ERK1 and ERK2 signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of ERK1 cascade" NARROW [GOC:add] +synonym: "positive regulation of ERK1/2 cascade" EXACT [GOC:add] +synonym: "positive regulation of ERK2 cascade" NARROW [GOC:add] +synonym: "positive regulation of MAPK1 cascade" NARROW [GOC:add] +synonym: "positive regulation of MAPK3 cascade" NARROW [GOC:add] +synonym: "stimulation of ERK1 and ERK2 cascade" NARROW [GOC:mah] +synonym: "up regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +synonym: "up-regulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +synonym: "upregulation of ERK1 and ERK2 cascade" EXACT [GOC:mah] +is_a: GO:0043410 ! positive regulation of MAPK cascade +is_a: GO:0070372 ! regulation of ERK1 and ERK2 cascade +relationship: positively_regulates GO:0070371 ! ERK1 and ERK2 cascade + +[Term] +id: GO:0070375 +name: ERK5 cascade +namespace: biological_process +def: "An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0896039986, PMID:16376520, PMID:16880823, PMID:20811974, PMID:28903453] +synonym: "big MAP kinase signaling cascade" EXACT [PMID:20811974] +synonym: "BMK cascade" EXACT [PMID:20811974] +synonym: "BMK signaling pathway" EXACT [GOC:mah] +synonym: "BMK signalling pathway" EXACT [GOC:mah] +synonym: "BMK1 cascade" EXACT [GOC:add] +synonym: "ERK5 signaling pathway" EXACT [PMID:16376520] +synonym: "extracellular signal-regulated kinase 5 cascade" EXACT [PMID:20811974] +synonym: "MAPK7 cascade" EXACT [GOC:add] +is_a: GO:0000165 ! MAPK cascade + +[Term] +id: GO:0070376 +name: regulation of ERK5 cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] +synonym: "regulation of BMK cascade" EXACT [GOC:signaling] +synonym: "regulation of BMK signaling pathway" EXACT [GOC:mah] +synonym: "regulation of BMK signalling pathway" EXACT [GOC:mah] +synonym: "regulation of BMK1 cascade" EXACT [GOC:add] +synonym: "regulation of ERK5 signaling pathway" EXACT [PMID:16376520] +synonym: "regulation of MAPK7 cascade" EXACT [GOC:add] +is_a: GO:0043408 ! regulation of MAPK cascade +relationship: regulates GO:0070375 ! ERK5 cascade + +[Term] +id: GO:0070377 +name: negative regulation of ERK5 cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:add, ISBN:0121245462, ISBN:0896039986] +synonym: "down regulation of BMK cascade" EXACT [GOC:mah] +synonym: "down-regulation of BMK cascade" EXACT [GOC:mah] +synonym: "downregulation of BMK cascade" EXACT [GOC:mah] +synonym: "inhibition of BMK cascade" NARROW [GOC:mah] +synonym: "negative regulation of BMK cascade" EXACT [GOC:signaling] +synonym: "negative regulation of BMK signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of BMK signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of BMK1 cascade" EXACT [GOC:add] +synonym: "negative regulation of ERK5 signaling pathway" EXACT [PMID:16376520] +synonym: "negative regulation of MAPK7 cascade" EXACT [GOC:add] +is_a: GO:0043409 ! negative regulation of MAPK cascade +is_a: GO:0070376 ! regulation of ERK5 cascade +relationship: negatively_regulates GO:0070375 ! ERK5 cascade + +[Term] +id: GO:0070378 +name: positive regulation of ERK5 cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK5 cascade." [GOC:mah] +synonym: "activation of BMK cascade" NARROW [GOC:mah] +synonym: "positive regulation of BMK cascade" EXACT [GOC:signaling] +synonym: "positive regulation of BMK signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of BMK signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of BMK1 cascade" EXACT [GOC:add] +synonym: "positive regulation of ERK5 signaling pathway" EXACT [PMID:16376520] +synonym: "positive regulation of MAPK7 cascade" EXACT [GOC:add] +synonym: "stimulation of BMK cascade" NARROW [GOC:mah] +synonym: "up regulation of BMK cascade" EXACT [GOC:mah] +synonym: "up-regulation of BMK cascade" EXACT [GOC:mah] +synonym: "upregulation of BMK cascade" EXACT [GOC:mah] +is_a: GO:0043410 ! positive regulation of MAPK cascade +is_a: GO:0070376 ! regulation of ERK5 cascade +relationship: positively_regulates GO:0070375 ! ERK5 cascade + +[Term] +id: GO:0070379 +name: high mobility group box 1 binding +namespace: molecular_function +def: "Binding to high mobility group box 1 (HMBGB1)." [GOC:add, PMID:18431461] +synonym: "HMGB1 binding" EXACT [GOC:add] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0070380 +name: high mobility group box 1 receptor activity +namespace: molecular_function +def: "Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, PMID:18431461] +synonym: "HMGB1 receptor activity" EXACT [GOC:add] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0070381 +name: endosome to plasma membrane transport vesicle +namespace: cellular_component +def: "A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah, PMID:10679016, PMID:12110576] +synonym: "endosome to plasma membrane constitutive secretory pathway transport vesicle" EXACT [] +synonym: "endosome-plasma membrane transport vesicle" EXACT [GOC:mah] +is_a: GO:0070382 ! exocytic vesicle + +[Term] +id: GO:0070382 +name: exocytic vesicle +namespace: cellular_component +def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] +synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] +synonym: "exocytotic vesicle" EXACT [GOC:kad] +is_a: GO:0030133 ! transport vesicle +is_a: GO:0099503 ! secretory vesicle + +[Term] +id: GO:0070383 +name: DNA cytosine deamination +namespace: biological_process +def: "The removal of an amino group from a cytosine residue in DNA, forming a uracil residue." [GOC:mah] +is_a: GO:0045006 ! DNA deamination + +[Term] +id: GO:0070384 +name: Harderian gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species." [GOC:hjd, PMID:16856596, PMID:7559104] +comment: Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages. +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0070385 +name: egasyn-beta-glucuronidase complex +namespace: cellular_component +def: "A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum." [PMID:7744842] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0070386 +name: procollagen-proline 4-dioxygenase complex, alpha(I) type +namespace: cellular_component +def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline)." [PMID:14500733, PMID:7753822] +synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type" EXACT [PMID:7753822] +synonym: "prolyl 4-hydroxylase complex (alpha(I)-type)" BROAD [CORUM:472] +is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex + +[Term] +id: GO:0070387 +name: procollagen-proline 4-dioxygenase complex, alpha(II) type +namespace: cellular_component +def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations." [PMID:14500733, PMID:7753822] +synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type" EXACT [PMID:7753822] +synonym: "prolyl 4-hydroxylase complex (alpha(II)-type)" BROAD [CORUM:473] +is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex + +[Term] +id: GO:0070388 +name: procollagen-proline 4-dioxygenase complex, alpha(III) type +namespace: cellular_component +def: "A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform." [PMID:14500733] +synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type" EXACT [PMID:14500733] +synonym: "prolyl 4-hydroxylase complex (alpha(III)-type)" BROAD [CORUM:474] +is_a: GO:0016222 ! procollagen-proline 4-dioxygenase complex + +[Term] +id: GO:0070390 +name: transcription export complex 2 +namespace: cellular_component +def: "A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p." [GOC:dgf, GOC:mah, PMID:17786152, PMID:19289793, PMID:28334829] +synonym: "Sac3-Thp1-Sus1-Sem1-Cdc31 complex" EXACT [PMID:17786152] +synonym: "TREX-2 complex" EXACT [GOC:dgf] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070391 +name: response to lipoteichoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "response to LTA" EXACT [GOC:add] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0070392 +name: detection of lipoteichoic acid +namespace: biological_process +def: "The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "detection of LTA" EXACT [GOC:add] +is_a: GO:0032490 ! detection of molecule of bacterial origin +is_a: GO:0070391 ! response to lipoteichoic acid + +[Term] +id: GO:0070393 +name: teichoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues." [GOC:add, PMID:14665680] +synonym: "teichoic acid breakdown" EXACT [GOC:add] +synonym: "teichoic acid catabolism" EXACT [GOC:add] +synonym: "teichoic acid degradation" EXACT [GOC:add] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:0046374 ! teichoic acid metabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process + +[Term] +id: GO:0070394 +name: lipoteichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "lipoteichoic acid metabolism" EXACT [GOC:add] +synonym: "LTA metabolic process" EXACT [GOC:add] +is_a: GO:0046374 ! teichoic acid metabolic process + +[Term] +id: GO:0070395 +name: lipoteichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "lipoteichoic acid anabolism" EXACT [GOC:add] +synonym: "lipoteichoic acid biosynthesis" EXACT [GOC:add] +synonym: "lipoteichoic acid formation" EXACT [GOC:add] +synonym: "lipoteichoic acid synthesis" EXACT [GOC:add] +synonym: "LTA biosynthetic process" BROAD [GOC:add] +is_a: GO:0019350 ! teichoic acid biosynthetic process +is_a: GO:0070394 ! lipoteichoic acid metabolic process + +[Term] +id: GO:0070396 +name: lipoteichoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipoteichoic acid, which is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:add, PMID:14665680] +synonym: "lipoteichoic acid breakdown" EXACT [GOC:add] +synonym: "lipoteichoic acid catabolism" EXACT [GOC:add] +synonym: "lipoteichoic acid degradation" EXACT [GOC:add] +is_a: GO:0070393 ! teichoic acid catabolic process +is_a: GO:0070394 ! lipoteichoic acid metabolic process + +[Term] +id: GO:0070397 +name: wall teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "wall teichoic acid metabolism" EXACT [GOC:add] +synonym: "WTA metabolic process" EXACT [GOC:add] +is_a: GO:0046374 ! teichoic acid metabolic process + +[Term] +id: GO:0070398 +name: wall teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "wall teichoic acid anabolism" EXACT [GOC:add] +synonym: "wall teichoic acid biosynthesis" EXACT [GOC:add] +synonym: "wall teichoic acid formation" EXACT [GOC:add] +synonym: "wall teichoic acid synthesis" EXACT [GOC:add] +synonym: "WTA biosynthetic process" EXACT [GOC:add] +is_a: GO:0019350 ! teichoic acid biosynthetic process +is_a: GO:0070397 ! wall teichoic acid metabolic process + +[Term] +id: GO:0070399 +name: wall teichoic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan." [GOC:add, PMID:14665680] +synonym: "wall teichoic acid breakdown" EXACT [GOC:add] +synonym: "wall teichoic acid catabolism" EXACT [GOC:add] +synonym: "wall teichoic acid degradation" EXACT [GOC:add] +is_a: GO:0070397 ! wall teichoic acid metabolic process + +[Term] +id: GO:0070400 +name: teichoic acid D-alanylation +namespace: biological_process +def: "The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid." [GOC:add, PMID:14665680, PMID:16020688] +synonym: "teichoic acid alanylation" EXACT [GOC:add] +is_a: GO:0019350 ! teichoic acid biosynthetic process + +[Term] +id: GO:0070401 +name: NADP+ binding +namespace: molecular_function +def: "Binding to the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] +synonym: "NADP (oxidized) binding" EXACT [GOC:mah] +synonym: "NADP binding" RELATED [GOC:mah] +synonym: "oxidized NADP binding" EXACT [GOC:mah] +synonym: "oxidized nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0050661 ! NADP binding + +[Term] +id: GO:0070402 +name: NADPH binding +namespace: molecular_function +def: "Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] +synonym: "NADP (reduced) binding" EXACT [GOC:mah] +synonym: "reduced NADP binding" EXACT [GOC:mah] +synonym: "reduced nicotinamide adenine dinucleotide phosphate binding" EXACT [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0050661 ! NADP binding + +[Term] +id: GO:0070403 +name: NAD+ binding +namespace: molecular_function +def: "Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] +synonym: "NAD (oxidized) binding" EXACT [GOC:mah] +synonym: "NAD binding" RELATED [GOC:mah] +synonym: "oxidized NAD binding" EXACT [GOC:mah] +synonym: "oxidized nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0051287 ! NAD binding + +[Term] +id: GO:0070404 +name: NADH binding +namespace: molecular_function +def: "Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions." [GOC:mah] +synonym: "NAD (reduced) binding" EXACT [GOC:mah] +synonym: "reduced NAD binding" EXACT [GOC:mah] +synonym: "reduced nicotinamide adenine dinucleotide binding" EXACT [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0051287 ! NAD binding + +[Term] +id: GO:0070405 +name: ammonium ion binding +namespace: molecular_function +def: "Binding to ammonium ions (NH4+)." [CHEBI:28938, GOC:ecd] +synonym: "ammonium binding" RELATED [] +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0070406 +name: glutamine binding +namespace: molecular_function +def: "Binding to glutamine, 2,5-diamino-5-oxopentanoic acid." [CHEBI:28300, GOC:ecd] +is_a: GO:0031406 ! carboxylic acid binding + +[Term] +id: GO:0070407 +name: oxidation-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein." [GOC:mah] +synonym: "oxidation-dependent protein breakdown" EXACT [GOC:mah] +synonym: "oxidation-dependent protein catabolism" EXACT [GOC:mah] +synonym: "oxidation-dependent protein degradation" EXACT [GOC:mah] +synonym: "oxidation-dependent proteolysis" EXACT [GOC:mah] +synonym: "oxidized protein catabolic process" EXACT [GOC:mah] +is_a: GO:0019941 ! modification-dependent protein catabolic process + +[Term] +id: GO:0070408 +name: carbamoyl phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] +synonym: "carbamoyl phosphate metabolism" EXACT [GOC:mah] +xref: UM-BBD_pathwayID:bzn +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process + +[Term] +id: GO:0070409 +name: carbamoyl phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways." [CHEBI:17672, GOC:mah, GOC:rph] +synonym: "carbamoyl phosphate anabolism" EXACT [] +synonym: "carbamoyl phosphate biosynthesis" EXACT [] +synonym: "carbamoyl phosphate formation" EXACT [] +synonym: "carbamoyl phosphate synthesis" EXACT [] +synonym: "carbamyl phosphate biosynthetic process" EXACT [GOC:rph] +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0070408 ! carbamoyl phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:0070410 +name: co-SMAD binding +namespace: molecular_function +def: "Binding to a common mediator SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] +synonym: "common mediator SMAD binding" EXACT [GOC:rl] +synonym: "common partner SMAD binding" EXACT [GOC:rl] +synonym: "common-mediator SMAD binding" EXACT [GOC:rl] +synonym: "common-partner SMAD binding" EXACT [GOC:rl] +is_a: GO:0046332 ! SMAD binding + +[Term] +id: GO:0070411 +name: I-SMAD binding +namespace: molecular_function +def: "Binding to an inhibitory SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] +is_a: GO:0046332 ! SMAD binding + +[Term] +id: GO:0070412 +name: R-SMAD binding +namespace: molecular_function +def: "Binding to a receptor-regulated SMAD signaling protein." [GOC:BHF, GOC:vk, PMID:19114992] +synonym: "pathway restricted SMAD binding" EXACT [GOC:rl] +synonym: "pathway-restricted SMAD binding" EXACT [GOC:rl] +synonym: "receptor regulated SMAD binding" EXACT [GOC:rl] +synonym: "receptor-regulated SMAD binding" EXACT [GOC:rl] +is_a: GO:0046332 ! SMAD binding + +[Term] +id: GO:0070413 +name: trehalose metabolism in response to stress +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress." [GOC:jp, GOC:mah, PMID:9797333] +synonym: "trehalose metabolic process involved in response to stress" EXACT systematic_synonym [GOC:mah] +is_a: GO:0005991 ! trehalose metabolic process +relationship: part_of GO:0033554 ! cellular response to stress + +[Term] +id: GO:0070414 +name: trehalose metabolism in response to heat stress +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] +synonym: "trehalose metabolic process involved in response to heat stress" EXACT systematic_synonym [GOC:mah] +is_a: GO:0070413 ! trehalose metabolism in response to stress +relationship: part_of GO:0034605 ! cellular response to heat + +[Term] +id: GO:0070415 +name: trehalose metabolism in response to cold stress +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp, GOC:mah, PMID:9797333] +synonym: "trehalose metabolic process involved in response to cold stress" EXACT systematic_synonym [GOC:mah] +is_a: GO:0070413 ! trehalose metabolism in response to stress +is_a: GO:0070417 ! cellular response to cold + +[Term] +id: GO:0070416 +name: trehalose metabolism in response to water deprivation +namespace: biological_process +def: "The chemical reactions and pathways involving trehalose that occur as a result of deprivation of water." [GOC:jp, GOC:mah, PMID:9797333] +synonym: "trehalose metabolic process involved in response to water deprivation" EXACT systematic_synonym [GOC:mah] +is_a: GO:0070413 ! trehalose metabolism in response to stress +relationship: part_of GO:0009414 ! response to water deprivation + +[Term] +id: GO:0070417 +name: cellular response to cold +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp] +synonym: "cellular response to cold stress" EXACT [GOC:jp] +is_a: GO:0009409 ! response to cold +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0070418 +name: DNA-dependent protein kinase complex +namespace: cellular_component +def: "A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku." [GOC:mah, PMID:10854421, PMID:12235392] +synonym: "DNA-dependent protein kinase, DNA-end-binding complex" NARROW [] +synonym: "DNA-PK complex" EXACT [] +synonym: "DNA-PK-Ku antigen complex" EXACT [CORUM:355] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0070419 +name: nonhomologous end joining complex +namespace: cellular_component +def: "A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends." [GOC:mah, PMID:17072889, PMID:17938628] +synonym: "NHEJ complex" EXACT [GOC:mah] +synonym: "non-homologous end joining complex" EXACT [GOC:mah] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990391 ! DNA repair complex + +[Term] +id: GO:0070420 +name: Ku-DNA ligase complex +namespace: cellular_component +def: "A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria." [GOC:mah, PMID:17938628] +is_a: GO:0070419 ! nonhomologous end joining complex + +[Term] +id: GO:0070421 +name: DNA ligase III-XRCC1 complex +namespace: cellular_component +def: "A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair." [PMID:15141024, PMID:7760816] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070422 +name: G-protein beta/gamma-Raf-1 complex +namespace: cellular_component +def: "A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7782277] +comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. +synonym: "G protein complex (GNG2, GNB2L1, RAF1)" RELATED [CORUM:1539] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070423 +name: nucleotide-binding oligomerization domain containing signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein." [GOC:add, PMID:17944960, PMID:18585455] +synonym: "NOD signaling pathway" EXACT [GOC:add] +synonym: "nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] +is_a: GO:0002753 ! cytoplasmic pattern recognition receptor signaling pathway +is_a: GO:0035872 ! nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway + +[Term] +id: GO:0070424 +name: regulation of nucleotide-binding oligomerization domain containing signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] +synonym: "regulation of NOD signaling pathway" EXACT [GOC:add] +synonym: "regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] +is_a: GO:0062207 ! regulation of pattern recognition receptor signaling pathway +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway + +[Term] +id: GO:0070425 +name: negative regulation of nucleotide-binding oligomerization domain containing signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] +synonym: "negative regulation of NOD signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] +is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway + +[Term] +id: GO:0070426 +name: positive regulation of nucleotide-binding oligomerization domain containing signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing (NOD) pathway." [GOC:add] +synonym: "positive regulation of NOD signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of nucleotide-binding oligomerization domain containing signalling pathway" EXACT [GOC:mah] +is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway +is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway + +[Term] +id: GO:0070427 +name: nucleotide-binding oligomerization domain containing 1 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1)." [GOC:add, PMID:17944960, PMID:18585455] +synonym: "NOD1 signaling pathway" EXACT [GOC:add] +synonym: "nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway + +[Term] +id: GO:0070428 +name: regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] +synonym: "regulation of NOD1 signaling pathway" EXACT [GOC:add] +synonym: "regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway +relationship: regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway + +[Term] +id: GO:0070429 +name: negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] +synonym: "negative regulation of NOD1 signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway +relationship: negatively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway + +[Term] +id: GO:0070430 +name: positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 1 (NOD1) pathway." [GOC:add] +synonym: "positive regulation of NOD1 signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of nucleotide-binding oligomerization domain containing 1 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:0070428 ! regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway +relationship: positively_regulates GO:0070427 ! nucleotide-binding oligomerization domain containing 1 signaling pathway + +[Term] +id: GO:0070431 +name: nucleotide-binding oligomerization domain containing 2 signaling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2)." [GOC:add, PMID:17944960, PMID:18585455] +synonym: "NOD2 signaling pathway" EXACT [GOC:add] +synonym: "nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070423 ! nucleotide-binding oligomerization domain containing signaling pathway + +[Term] +id: GO:0070432 +name: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] +synonym: "regulation of NOD2 signaling pathway" EXACT [GOC:add] +synonym: "regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070424 ! regulation of nucleotide-binding oligomerization domain containing signaling pathway +relationship: regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway + +[Term] +id: GO:0070433 +name: negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] +synonym: "negative regulation of NOD2 signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070425 ! negative regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway +relationship: negatively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway + +[Term] +id: GO:0070434 +name: positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway." [GOC:add] +synonym: "positive regulation of NOD2 signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of nucleotide-binding oligomerization domain containing 2 signalling pathway" EXACT [GOC:mah] +is_a: GO:0070426 ! positive regulation of nucleotide-binding oligomerization domain containing signaling pathway +is_a: GO:0070432 ! regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway +relationship: positively_regulates GO:0070431 ! nucleotide-binding oligomerization domain containing 2 signaling pathway + +[Term] +id: GO:0070435 +name: Shc-EGFR complex +namespace: cellular_component +def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] +synonym: "Shc-Egfr complex, EGF stimulated" NARROW [CORUM:2887] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070436 +name: Grb2-EGFR complex +namespace: cellular_component +def: "A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] +synonym: "Grb2-Egfr complex, EGF stimulated" NARROW [CORUM:2889] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070437 +name: Grb2-Shc complex +namespace: cellular_component +def: "A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway." [GOC:mah, PMID:7798267] +synonym: "Grb2-Shc complex, EGF stimulated" NARROW [CORUM:2888] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070438 +name: obsolete mTOR-FKBP12-rapamycin complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus)." [GOC:sl, PMID:20005306, PMID:7822316] +comment: This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally. +synonym: "Fkbp1a-Frap1 complex" NARROW [CORUM:2987] +synonym: "mTOR-FKBP12-rapamycin complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0070439 +name: Mad-Max-mSin3A complex +namespace: cellular_component +def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p." [PMID:7889570] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0070440 +name: Mad-Max-mSin3B complex +namespace: cellular_component +def: "A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p." [PMID:7889570] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0070441 +name: G-protein beta/gamma-Btk complex +namespace: cellular_component +def: "A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein." [GOC:mah, PMID:7972043] +comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. +synonym: "G protein complex (BTK, GNG1, GNG2)" RELATED [CORUM:1615] +synonym: "G protein complex (Btk, Gng2, Gnb1)" RELATED [CORUM:3195] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070442 +name: integrin alphaIIb-beta3 complex +namespace: cellular_component +def: "An integrin complex that comprises one alphaIIb subunit and one beta3 subunit." [PMID:12297042] +synonym: "alphaIIb-beta3 integrin complex" EXACT [] +synonym: "ITGA2B-ITGB3 complex" NARROW [CORUM:2381] +is_a: GO:0008305 ! integrin complex + +[Term] +id: GO:0070443 +name: Mad-Max complex +namespace: cellular_component +def: "A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max." [PMID:8224841] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0070444 +name: oligodendrocyte progenitor proliferation +namespace: biological_process +def: "The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system." [GOC:mah, GOC:sl, PMID:15504915] +synonym: "oligodendrocyte precursor proliferation" EXACT [GOC:mah] +is_a: GO:0061351 ! neural precursor cell proliferation +relationship: part_of GO:0042063 ! gliogenesis + +[Term] +id: GO:0070445 +name: regulation of oligodendrocyte progenitor proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] +synonym: "regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: regulates GO:0070444 ! oligodendrocyte progenitor proliferation + +[Term] +id: GO:0070446 +name: negative regulation of oligodendrocyte progenitor proliferation +namespace: biological_process +def: "Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] +synonym: "negative regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] +is_a: GO:0014014 ! negative regulation of gliogenesis +is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation +is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation + +[Term] +id: GO:0070447 +name: positive regulation of oligodendrocyte progenitor proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation." [GOC:mah, GOC:sl] +synonym: "positive regulation of oligodendrocyte precursor proliferation" EXACT [GOC:mah] +is_a: GO:0014015 ! positive regulation of gliogenesis +is_a: GO:0070445 ! regulation of oligodendrocyte progenitor proliferation +is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0070444 ! oligodendrocyte progenitor proliferation + +[Term] +id: GO:0070448 +name: laricitrin 5'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." [RHEA:25633] +comment: Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267. +synonym: "CrCOMT2" RELATED [] +synonym: "flavonoid 3',5'-O-dimethyltransferase activity" RELATED [] +synonym: "S-adenosyl-L-methionine:myricetin O-methyltransferase activity" RELATED [] +xref: EC:2.1.1.267 +xref: KEGG_REACTION:R06816 +xref: MetaCyc:RXN-8452 +xref: RHEA:25633 +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0070449 +name: elongin complex +namespace: cellular_component +def: "A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." [PMID:12676794] +comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. +synonym: "elongin (SIII) complex" EXACT [CORUM:56] +synonym: "transcription elongation factor SIII complex" EXACT [PMID:8244996] +synonym: "transcription factor B (SIII) complex" EXACT [] +is_a: GO:0008023 ! transcription elongation factor complex + +[Term] +id: GO:0070450 +name: interleukin4-interleukin-4 receptor complex +namespace: cellular_component +def: "A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule." [GOC:mah, PMID:10358772] +synonym: "IL4-IL4 receptor complex" EXACT [GOC:mah] +synonym: "IL4-IL4R-IL2RG complex" NARROW [CORUM:1515] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070451 +name: cell hair +namespace: cellular_component +def: "A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located." [PMID:11526084] +synonym: "imaginal disc-derived wing hair" NARROW [GOC:mah] +synonym: "non-sensory hair" EXACT [GOC:bf] +xref: Wikipedia:Membrane_nanotube +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0070452 +name: positive regulation of ergosterol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] +synonym: "activation of ergosterol biosynthetic process" NARROW [] +synonym: "positive regulation of ergosterol anabolism" EXACT [] +synonym: "positive regulation of ergosterol biosynthesis" EXACT [] +synonym: "positive regulation of ergosterol formation" EXACT [] +synonym: "positive regulation of ergosterol synthesis" EXACT [] +synonym: "stimulation of ergosterol biosynthetic process" NARROW [] +synonym: "up regulation of ergosterol biosynthetic process" EXACT [] +synonym: "up-regulation of ergosterol biosynthetic process" EXACT [] +synonym: "upregulation of ergosterol biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032443 ! regulation of ergosterol biosynthetic process +is_a: GO:0106120 ! positive regulation of sterol biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0006696 ! ergosterol biosynthetic process + +[Term] +id: GO:0070453 +name: regulation of heme biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] +synonym: "regulation of haem biosynthesis" EXACT [GOC:mah] +synonym: "regulation of haem biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of heme anabolism" EXACT [GOC:mah] +synonym: "regulation of heme biosynthesis" EXACT [GOC:mah] +synonym: "regulation of heme formation" EXACT [GOC:mah] +synonym: "regulation of heme synthesis" EXACT [GOC:mah] +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +relationship: regulates GO:0006783 ! heme biosynthetic process + +[Term] +id: GO:0070454 +name: negative regulation of heme biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] +synonym: "down regulation of heme biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of heme biosynthetic process" EXACT [GOC:mah] +synonym: "downregulation of heme biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of heme biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of haem biosynthetic process" EXACT [GOC:mah] +synonym: "negative regulation of heme anabolism" EXACT [GOC:mah] +synonym: "negative regulation of heme biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of heme formation" EXACT [GOC:mah] +synonym: "negative regulation of heme synthesis" EXACT [GOC:mah] +is_a: GO:0070453 ! regulation of heme biosynthetic process +is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process +relationship: negatively_regulates GO:0006783 ! heme biosynthetic process + +[Term] +id: GO:0070455 +name: positive regulation of heme biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme." [GOC:mah] +synonym: "activation of heme biosynthetic process" NARROW [GOC:mah] +synonym: "positive regulation of haem biosynthetic process" EXACT [GOC:mah] +synonym: "positive regulation of heme anabolism" EXACT [GOC:mah] +synonym: "positive regulation of heme biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of heme formation" EXACT [GOC:mah] +synonym: "positive regulation of heme synthesis" EXACT [GOC:mah] +synonym: "stimulation of heme biosynthetic process" NARROW [GOC:mah] +synonym: "up regulation of heme biosynthetic process" EXACT [GOC:mah] +synonym: "up-regulation of heme biosynthetic process" EXACT [GOC:mah] +synonym: "upregulation of heme biosynthetic process" EXACT [GOC:mah] +is_a: GO:0070453 ! regulation of heme biosynthetic process +is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process +relationship: positively_regulates GO:0006783 ! heme biosynthetic process + +[Term] +id: GO:0070456 +name: galactose-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate." [GOC:mah] +is_a: GO:0050308 ! sugar-phosphatase activity + +[Term] +id: GO:0070457 +name: D-galactose-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate." [GOC:mah, PMID:9462881] +is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity + +[Term] +id: GO:0070458 +name: cellular detoxification of nitrogen compound +namespace: biological_process +def: "Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances." [GOC:mah] +synonym: "cellular detoxification of nitrogenous compound" EXACT [GOC:mah] +is_a: GO:0051410 ! detoxification of nitrogen compound +is_a: GO:1990748 ! cellular detoxification +relationship: part_of GO:0033554 ! cellular response to stress + +[Term] +id: GO:0070459 +name: prolactin secretion +namespace: biological_process +def: "The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] +is_a: GO:0009306 ! protein secretion +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0070460 +name: thyroid-stimulating hormone secretion +namespace: biological_process +def: "The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary." [GOC:mah, ISBN:0198506732] +synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah] +synonym: "TSH secretion" EXACT [] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0070461 +name: SAGA-type complex +namespace: cellular_component +def: "A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs)." [GOC:mah, PMID:10637607, PMID:17337012] +synonym: "SAGA family complex" EXACT [PMID:17337012] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0070462 +name: plus-end specific microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from the plus end of a microtubule." [GOC:krc, PMID:16906145, PMID:16906148] +is_a: GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:0070463 +name: tubulin-dependent ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate." [GOC:mah, PMID:16906148] +synonym: "tubulin-activated ATPase activity" EXACT [] +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0070464 +name: alphav-beta3 integrin-collagen alpha3(VI) complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen." [PMID:8387021] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070465 +name: alpha1-beta1 integrin-alpha3(VI) complex +namespace: cellular_component +def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] +synonym: "ITGA1-ITGB1-COL6A3 complex" NARROW [CORUM:2434] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070466 +name: alpha2-beta1 integrin-alpha3(VI) complex +namespace: cellular_component +def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain." [PMID:8387021] +synonym: "ITGA2-ITGB1-COL6A3 complex" NARROW [CORUM:2431] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070467 +name: RC-1 DNA recombination complex +namespace: cellular_component +def: "A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA." [PMID:8392064, PMID:8670910] +synonym: "DNA recombination complex RC-1" EXACT [GOC:mah] +synonym: "RC-1 complex (recombination complex 1)" EXACT [CORUM:364] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070468 +name: dentin extracellular matrix secretion +namespace: biological_process +def: "The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin." [GOC:mah, PMID:12856968] +synonym: "dentin secretion" RELATED [] +synonym: "dentine secretion" RELATED [GOC:mah] +synonym: "predentin secretion" RELATED [] +is_a: GO:0070278 ! extracellular matrix constituent secretion +relationship: part_of GO:0042475 ! odontogenesis of dentin-containing tooth + +[Term] +id: GO:0070469 +name: respirasome +namespace: cellular_component +def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684, Wikipedia:Respirasome] +synonym: "membrane electron transport chain" EXACT [GOC:mah] +synonym: "respiratory chain" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0070470 +name: plasma membrane respirasome +namespace: cellular_component +def: "A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:imk, GOC:mah, ISBN:0198547684] +synonym: "plasma membrane electron transport chain" EXACT [GOC:mah] +synonym: "plasma membrane respiratory chain" EXACT [] +is_a: GO:0070469 ! respirasome +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0070471 +name: uterine smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth." [GOC:sl] +synonym: "myometrial contraction" EXACT [GOC:sl] +synonym: "myometrial smooth muscle contraction" EXACT [GOC:sl] +synonym: "myometrium contraction" EXACT [GOC:sl] +is_a: GO:0006939 ! smooth muscle contraction + +[Term] +id: GO:0070472 +name: regulation of uterine smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] +synonym: "regulation of myometrial contraction" EXACT [GOC:sl] +synonym: "regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] +synonym: "regulation of myometrium contraction" EXACT [GOC:sl] +is_a: GO:0006940 ! regulation of smooth muscle contraction +relationship: regulates GO:0070471 ! uterine smooth muscle contraction + +[Term] +id: GO:0070473 +name: negative regulation of uterine smooth muscle contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] +synonym: "down regulation of uterine smooth muscle contraction" EXACT [GOC:mah] +synonym: "down-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] +synonym: "downregulation of uterine smooth muscle contraction" EXACT [GOC:mah] +synonym: "inhibition of uterine smooth muscle contraction" NARROW [GOC:mah] +synonym: "negative regulation of myometrial contraction" EXACT [GOC:sl] +synonym: "negative regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] +synonym: "negative regulation of myometrium contraction" EXACT [GOC:sl] +synonym: "uterine smooth muscle relaxation" RELATED [GOC:mah] +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +is_a: GO:0070472 ! regulation of uterine smooth muscle contraction +relationship: negatively_regulates GO:0070471 ! uterine smooth muscle contraction + +[Term] +id: GO:0070474 +name: positive regulation of uterine smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of uterine smooth muscle contraction." [GOC:go_curators] +synonym: "activation of uterine smooth muscle contraction" NARROW [GOC:mah] +synonym: "positive regulation of myometrial contraction" EXACT [GOC:sl] +synonym: "positive regulation of myometrial smooth muscle contraction" EXACT [GOC:sl] +synonym: "positive regulation of myometrium contraction" EXACT [GOC:sl] +synonym: "stimulation of uterine smooth muscle contraction" NARROW [GOC:mah] +synonym: "up regulation of uterine smooth muscle contraction" EXACT [GOC:mah] +synonym: "up-regulation of uterine smooth muscle contraction" EXACT [GOC:mah] +synonym: "upregulation of uterine smooth muscle contraction" EXACT [GOC:mah] +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +is_a: GO:0070472 ! regulation of uterine smooth muscle contraction +relationship: positively_regulates GO:0070471 ! uterine smooth muscle contraction + +[Term] +id: GO:0070475 +name: rRNA base methylation +namespace: biological_process +def: "The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule." [GOC:mah] +is_a: GO:0031167 ! rRNA methylation + +[Term] +id: GO:0070476 +name: rRNA (guanine-N7)-methylation +namespace: biological_process +def: "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule." [GOC:mah] +is_a: GO:0036265 ! RNA (guanine-N7)-methylation +is_a: GO:0070475 ! rRNA base methylation + +[Term] +id: GO:0070477 +name: endospore core +namespace: cellular_component +def: "An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive." [GOC:mah, PMID:15035041, PMID:18035610] +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0070478 +name: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction." [PMID:12769863] +synonym: "3'-5' NMD" EXACT [GOC:jp] +synonym: "3'-5' nonsense-mediated decay" EXACT [GOC:jp] +synonym: "3'-5' nonsense-mediated mRNA decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +is_a: GO:0034427 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' + +[Term] +id: GO:0070479 +name: nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [PMID:18554525] +synonym: "5'-3' NMD" EXACT [GOC:jp] +synonym: "5'-3' nonsense-mediated decay" EXACT [GOC:jp] +synonym: "5'-3' nonsense-mediated mRNA decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay" EXACT [GOC:mah] +is_a: GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +is_a: GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' +is_a: GO:0070480 ! exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay + +[Term] +id: GO:0070480 +name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay." [GOC:jp] +synonym: "exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay" EXACT [GOC:mah] +synonym: "exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay" EXACT [GOC:mah] +synonym: "exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay" EXACT [GOC:mah] +is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic +relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay + +[Term] +id: GO:0070481 +name: nuclear-transcribed mRNA catabolic process, non-stop decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon." [PMID:11910110] +synonym: "non-stop decay" EXACT [GOC:jp] +synonym: "non-stop mRNA decay" EXACT [GOC:jp] +synonym: "nonstop mRNA decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA breakdown, non-stop decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA catabolism, non-stop decay" EXACT [GOC:mah] +synonym: "nuclear-transcribed mRNA degradation, non-stop decay" EXACT [GOC:mah] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0070482 +name: response to oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0070483 +name: detection of hypoxia +namespace: biological_process +def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] +synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] +is_a: GO:0001666 ! response to hypoxia +is_a: GO:0003032 ! detection of oxygen + +[Term] +id: GO:0070484 +name: dehydro-D-arabinono-1,4-lactone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah] +synonym: "dehydro-D-arabinono-1,4-lactone metabolism" EXACT [GOC:mah] +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:0070485 +name: dehydro-D-arabinono-1,4-lactone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dehydro-D-arabinono-1,4-lactone, the gamma-lactone (5R)-3,4-dihydroxy-5-(hydroxymethyl)furan-2(5H)-one." [GOC:cjk, GOC:mah] +synonym: "dehydro-D-arabinono-1,4-lactone anabolism" EXACT [GOC:mah] +synonym: "dehydro-D-arabinono-1,4-lactone biosynthesis" EXACT [GOC:mah] +synonym: "dehydro-D-arabinono-1,4-lactone formation" EXACT [GOC:mah] +synonym: "dehydro-D-arabinono-1,4-lactone synthesis" EXACT [GOC:mah] +is_a: GO:0070484 ! dehydro-D-arabinono-1,4-lactone metabolic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0070486 +name: leukocyte aggregation +namespace: biological_process +def: "The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules." [GOC:sl, PMID:12972508] +synonym: "immune cell aggregation" EXACT [CL:0000738] +synonym: "leucocyte aggregation" EXACT [CL:0000738, GOC:sl] +synonym: "white blood cell aggregation" EXACT [CL:0000738, GOC:sl] +synonym: "white corpuscle aggregation" EXACT [GOC:sl] +is_a: GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:0070487 +name: monocyte aggregation +namespace: biological_process +def: "The adhesion of one monocyte to one or more other monocytes via adhesion molecules." [GOC:sl, PMID:12972508] +synonym: "mononuclear phagocyte aggregation" EXACT [GOC:sl] +is_a: GO:0070486 ! leukocyte aggregation + +[Term] +id: GO:0070488 +name: neutrophil aggregation +namespace: biological_process +def: "The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules." [GOC:sl, PMID:12972508] +synonym: "neutrocyte aggregation" EXACT [CL:0000775, GOC:mah] +synonym: "neutrophil leucocyte aggregation" EXACT [CL:0000775, GOC:mah] +synonym: "neutrophil leukocyte aggregation" EXACT [CL:0000775, GOC:mah] +synonym: "neutrophilic leucocyte aggregation" EXACT [CL:0000775, GOC:mah] +synonym: "neutrophilic leukocyte aggregation" EXACT [CL:0000775, GOC:mah] +is_a: GO:0070486 ! leukocyte aggregation + +[Term] +id: GO:0070489 +name: T cell aggregation +namespace: biological_process +def: "The adhesion of one T cell to one or more other T cells via adhesion molecules." [GOC:sl, PMID:12972508] +synonym: "T lymphocyte aggregation" EXACT [CL:0000084, GOC:sl] +synonym: "T-cell aggregation" EXACT [CL:0000084, GOC:mah] +synonym: "T-lymphocyte aggregation" EXACT [CL:0000084, GOC:mah] +is_a: GO:0071593 ! lymphocyte aggregation + +[Term] +id: GO:0070490 +name: protein pupylation +namespace: biological_process +def: "The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein." [PMID:18980670] +synonym: "Pup-protein conjugation" EXACT [GOC:mah] +synonym: "pupylation" EXACT [GOC:mah] +is_a: GO:0018205 ! peptidyl-lysine modification +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0070492 +name: oligosaccharide binding +namespace: molecular_function +def: "Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:mah] +is_a: GO:0030246 ! carbohydrate binding + +[Term] +id: GO:0070493 +name: thrombin-activated receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah, PMID:1672265] +synonym: "thrombin receptor signaling pathway" EXACT [] +synonym: "thrombin receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0070494 +name: regulation of thrombin-activated receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a thrombin-activated receptor signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "regulation of thrombin receptor signaling pathway" EXACT [] +synonym: "regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0070493 ! thrombin-activated receptor signaling pathway + +[Term] +id: GO:0070495 +name: negative regulation of thrombin-activated receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "negative regulation of thrombin receptor signaling pathway" EXACT [] +synonym: "negative regulation of thrombin receptor signalling pathway" RELATED [GOC:mah] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway +relationship: negatively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway + +[Term] +id: GO:0070496 +name: positive regulation of thrombin-activated receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "positive regulation of thrombin receptor signaling pathway" EXACT [] +synonym: "positive regulation of thrombin receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0070494 ! regulation of thrombin-activated receptor signaling pathway +relationship: positively_regulates GO:0070493 ! thrombin-activated receptor signaling pathway + +[Term] +id: GO:0070497 +name: 6-carboxy-5,6,7,8-tetrahydropterin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+." [GOC:imk, MetaCyc:RXN0-5507, PMID:19231875] +xref: EC:4.1.2.50 +xref: MetaCyc:RXN0-5507 +xref: RHEA:27966 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0070498 +name: interleukin-1-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] +synonym: "IL-1 alpha-mediated signaling pathway" NARROW [GOC:add] +synonym: "IL-1 beta-mediated signaling pathway" NARROW [GOC:add] +synonym: "IL-1-mediated signaling pathway" EXACT [GOC:mah] +synonym: "interleukin-1 alpha-mediated signaling pathway" NARROW [GOC:add] +synonym: "interleukin-1 beta-mediated signaling pathway" NARROW [GOC:add] +synonym: "interleukin-1-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0071347 ! cellular response to interleukin-1 + +[Term] +id: GO:0070499 +name: exosporium assembly +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore." [GOC:mah] +synonym: "exosporium formation" EXACT [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0045229 ! external encapsulating structure organization + +[Term] +id: GO:0070500 +name: poly-gamma-glutamate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] +synonym: "poly-gamma-glutamate metabolism" EXACT [GOC:mah] +is_a: GO:0044260 ! cellular macromolecule metabolic process + +[Term] +id: GO:0070501 +name: poly-gamma-glutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds." [GOC:mah, PMID:16689787] +synonym: "poly-gamma-glutamate anabolism" EXACT [GOC:mah] +synonym: "poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] +synonym: "poly-gamma-glutamate formation" EXACT [GOC:mah] +synonym: "poly-gamma-glutamate synthesis" EXACT [GOC:mah] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0070500 ! poly-gamma-glutamate metabolic process + +[Term] +id: GO:0070502 +name: capsule poly-gamma-glutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule." [GOC:mah, PMID:16689787] +synonym: "capsular poly-gamma-glutamate biosynthetic process" EXACT [GOC:mah] +synonym: "capsule poly-gamma-glutamate anabolism" EXACT [GOC:mah] +synonym: "capsule poly-gamma-glutamate biosynthesis" EXACT [GOC:mah] +synonym: "capsule poly-gamma-glutamate formation" EXACT [GOC:mah] +synonym: "capsule poly-gamma-glutamate synthesis" EXACT [GOC:mah] +is_a: GO:0045230 ! capsule organization +is_a: GO:0070501 ! poly-gamma-glutamate biosynthetic process + +[Term] +id: GO:0070503 +name: selenium-containing prosthetic group metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] +synonym: "selenium-containing prosthetic group metabolism" EXACT [GOC:mah] +is_a: GO:0001887 ! selenium compound metabolic process +is_a: GO:0051189 ! prosthetic group metabolic process + +[Term] +id: GO:0070504 +name: selenium-containing prosthetic group biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments." [GOC:dh, GOC:mah] +synonym: "selenium-containing prosthetic group anabolism" EXACT [GOC:mah] +synonym: "selenium-containing prosthetic group biosynthesis" EXACT [GOC:mah] +synonym: "selenium-containing prosthetic group formation" EXACT [GOC:mah] +synonym: "selenium-containing prosthetic group synthesis" EXACT [GOC:mah] +is_a: GO:0051191 ! prosthetic group biosynthetic process +is_a: GO:0070503 ! selenium-containing prosthetic group metabolic process + +[Term] +id: GO:0070505 +name: pollen coat +namespace: cellular_component +def: "A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma." [GOC:mah, GOC:rph, PMID:12930826, PMID:15012271] +synonym: "pollenkitt" EXACT [PMID:15012271] +synonym: "tryphine" EXACT [PMID:15012271] +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:0070506 +name: high-density lipoprotein particle receptor activity +namespace: molecular_function +def: "Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis." [GOC:bf, GOC:BHF, GOC:rl, PMID:9211901] +synonym: "HDL receptor" EXACT [GOC:rl] +synonym: "high-density lipoprotein receptor activity" EXACT [GOC:dph] +is_a: GO:0030228 ! lipoprotein particle receptor activity + +[Term] +id: GO:0070507 +name: regulation of microtubule cytoskeleton organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] +synonym: "regulation of microtubule cytoskeleton organisation" EXACT [GOC:mah] +synonym: "regulation of microtubule dynamics" EXACT [GOC:dph, GOC:tb] +is_a: GO:0032886 ! regulation of microtubule-based process +is_a: GO:0051493 ! regulation of cytoskeleton organization +relationship: regulates GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0070508 +name: cholesterol import +namespace: biological_process +def: "The directed movement of cholesterol into a cell or organelle." [GOC:BHF, GOC:rl] +synonym: "cholesterol uptake" EXACT [GOC:rl] +is_a: GO:0030301 ! cholesterol transport +is_a: GO:0035376 ! sterol import + +[Term] +id: GO:0070509 +name: calcium ion import +namespace: biological_process +def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah] +synonym: "calcium ion uptake" EXACT [GOC:mah] +synonym: "transmembrane calcium influx" RELATED [GOC:tb] +is_a: GO:0006816 ! calcium ion transport + +[Term] +id: GO:0070510 +name: regulation of histone H4-K20 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0070511 +name: negative regulation of histone H4-K20 methylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] +synonym: "down regulation of histone H4-K20 methylation" EXACT [GOC:mah] +synonym: "down-regulation of histone H4-K20 methylation" EXACT [GOC:mah] +synonym: "downregulation of histone H4-K20 methylation" EXACT [GOC:mah] +synonym: "inhibition of histone H4-K20 methylation" NARROW [GOC:mah] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:0070510 ! regulation of histone H4-K20 methylation +relationship: negatively_regulates GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0070512 +name: positive regulation of histone H4-K20 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 20 of histone H4." [GOC:mah] +synonym: "activation of histone H4-K20 methylation" NARROW [GOC:mah] +synonym: "stimulation of histone H4-K20 methylation" NARROW [GOC:mah] +synonym: "up regulation of histone H4-K20 methylation" EXACT [GOC:mah] +synonym: "up-regulation of histone H4-K20 methylation" EXACT [GOC:mah] +synonym: "upregulation of histone H4-K20 methylation" EXACT [GOC:mah] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:0070510 ! regulation of histone H4-K20 methylation +relationship: positively_regulates GO:0034770 ! histone H4-K20 methylation + +[Term] +id: GO:0070513 +name: death domain binding +namespace: molecular_function +def: "Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB." [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531] +comment: For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'. +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070514 +name: SRF-myogenin-E12 complex +namespace: cellular_component +def: "A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes." [PMID:8617811] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0070515 +name: alphaIIb-beta3 integrin-talin complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin." [PMID:8663236] +synonym: "ITGA2b-ITGB3-TLN1 complex" NARROW [CORUM:2378] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070516 +name: CAK-ERCC2 complex +namespace: cellular_component +def: "A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2." [PMID:8692841, PMID:8692842] +synonym: "cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex" EXACT [GOC:mah] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070517 +name: DNA replication factor C core complex +namespace: cellular_component +def: "A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37." [PMID:8692848, PMID:9228079, PMID:9582326] +synonym: "RFC core complex" EXACT [CORUM:278] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043599 ! nuclear DNA replication factor C complex + +[Term] +id: GO:0070518 +name: alpha4-beta1 integrin-CD53 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family." [PMID:8757325] +synonym: "ITGA4-ITGB1-CD53 complex" NARROW [CORUM:2420] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070519 +name: alpha4-beta1 integrin-CD63 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8757325] +synonym: "ITGA4-ITGB1-CD63 complex" NARROW [CORUM:2424] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070520 +name: alpha4-beta1 integrin-CD81 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family." [PMID:10229664, PMID:8757325] +synonym: "ITGA4-ITGB1-CD81 complex" NARROW [CORUM:2419] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070521 +name: alpha4-beta1 integrin-CD82 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family." [PMID:8757325] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070522 +name: ERCC4-ERCC1 complex +namespace: cellular_component +def: "A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae." [PMID:14734547] +comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. +synonym: "Rad1-Rad10 complex" EXACT [GOC:mah] +synonym: "XPF-ERCC1 complex" EXACT [PMID:14734547] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0070523 +name: 11-beta-hydroxysteroid dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+." [PMID:15761036, RHEA:53116] +xref: RHEA:53116 +xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase +is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity + +[Term] +id: GO:0070524 +name: 11-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+." [RHEA:11388] +synonym: "beta-hydroxysteroid dehydrogenase" BROAD [] +synonym: "corticosteroid 11-beta-dehydrogenase activity" RELATED [EC:1.1.1.146] +xref: EC:1.1.1.146 +xref: RHEA:11388 +xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase +is_a: GO:0003845 ! 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity + +[Term] +id: GO:0070525 +name: tRNA threonylcarbamoyladenosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules." [GOC:imk, GOC:mah, PMID:19287007] +synonym: "t6A metabolic process" EXACT [PMID:19287007] +synonym: "t6A metabolism" EXACT [PMID:19287007] +synonym: "threonylcarbamoyladenosine metabolism" EXACT [GOC:MAH] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0070527 +name: platelet aggregation +namespace: biological_process +def: "The adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF, GOC:vk] +synonym: "blood platelet aggregation" EXACT [CL:0000233] +synonym: "thrombocyte aggregation" RELATED [CL:0000233] +is_a: GO:0034109 ! homotypic cell-cell adhesion +relationship: part_of GO:0030168 ! platelet activation + +[Term] +id: GO:0070528 +name: protein kinase C signaling +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:mah] +synonym: "PKC signal transduction" EXACT [GOC:signaling] +synonym: "PKC signaling cascade" RELATED [GOC:mah] +synonym: "protein kinase C signal transduction" EXACT [GOC:signaling] +synonym: "protein kinase C signaling cascade" RELATED [GOC:signaling] +synonym: "protein kinase C signalling cascade" RELATED [GOC:mah] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0070529 +name: L-tryptophan aminotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid." [GOC:mah] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0070530 +name: K63-linked polyubiquitin modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein." [GOC:mah, PMID:15556404, PMID:17525341] +is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding + +[Term] +id: GO:0070531 +name: BRCA1-A complex +namespace: cellular_component +def: "A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites." [GOC:mah, PMID:19261749] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070532 +name: BRCA1-B complex +namespace: cellular_component +def: "A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites." [GOC:mah, PMID:16391231] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070533 +name: BRCA1-C complex +namespace: cellular_component +def: "A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint." [GOC:mah, PMID:15485915, PMID:16391231] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070534 +name: protein K63-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair." [GOC:mah, PMID:15556404] +synonym: "protein K63-linked polyubiquitination" EXACT [GOC:mah] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0070535 +name: histone H2A K63-linked ubiquitination +namespace: biological_process +def: "A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:18430235] +is_a: GO:0033522 ! histone H2A ubiquitination +is_a: GO:0070534 ! protein K63-linked ubiquitination + +[Term] +id: GO:0070536 +name: protein K63-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein." [GOC:mah, PMID:19202061, PMID:19214193] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0070537 +name: histone H2A K63-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX." [GOC:mah, PMID:19202061, PMID:19214193] +is_a: GO:0016578 ! histone deubiquitination +is_a: GO:0070536 ! protein K63-linked deubiquitination + +[Term] +id: GO:0070538 +name: oleic acid binding +namespace: molecular_function +def: "Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid." [GOC:lp, GOC:mah] +is_a: GO:0005504 ! fatty acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0070539 +name: linoleic acid binding +namespace: molecular_function +def: "Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid." [GOC:lp, GOC:mah] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0070540 +name: stearic acid binding +namespace: molecular_function +def: "Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid." [GOC:lp, GOC:mah] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:0070541 +name: response to platinum ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:sl] +synonym: "response to platinum" EXACT [GOC:mah] +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0070542 +name: response to fatty acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:lp] +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0070543 +name: response to linoleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:lp] +synonym: "response to linoleate" EXACT [GOC:mah] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:0070544 +name: histone H3-K36 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone." [GOC:sart, PMID:19061644] +synonym: "H3K36 demethylation" RELATED [] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0070545 +name: PeBoW complex +namespace: cellular_component +def: "A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively." [GOC:ab, GOC:mah, PMID:16043514, PMID:17353269] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005730 ! nucleolus +relationship: part_of GO:0030686 ! 90S preribosome + +[Term] +id: GO:0070546 +name: L-phenylalanine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid." [GOC:mah] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0070547 +name: L-tyrosine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid." [GOC:mah] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0070548 +name: L-glutamine aminotransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid." [GOC:mah] +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0070549 +name: siRNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA." [GOC:mah, PMID:18771919] +synonym: "down regulation of translation involved in RNA interference" EXACT [GOC:mah] +synonym: "down-regulation of translation involved in RNA interference" EXACT [GOC:mah] +synonym: "downregulation of translation involved in RNA interference" EXACT [GOC:mah] +synonym: "inhibition of translation involved in RNA interference" NARROW [GOC:mah] +synonym: "negative regulation of translation involved in RNA interference" EXACT [] +synonym: "RNA interference, negative regulation of translation" EXACT [GOC:mah] +is_a: GO:0040033 ! RNA-mediated gene silencing by inhibition of translation + +[Term] +id: GO:0070550 +name: rDNA condensation +namespace: biological_process +def: "The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase." [GOC:dgf, PMID:10811823, PMID:15137940] +synonym: "rDNA packaging" EXACT [] +is_a: GO:0006323 ! DNA packaging +relationship: part_of GO:0030261 ! chromosome condensation +relationship: part_of GO:1990700 ! nucleolar chromatin organization + +[Term] +id: GO:0070551 +name: endoribonuclease activity, cleaving siRNA-paired mRNA +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters." [GOC:mah, PMID:15105377] +synonym: "argonaute endoribonuclease activity" RELATED [GOC:mah] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0070552 +name: BRISC complex +namespace: cellular_component +def: "A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains." [GOC:mah, PMID:19214193] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070553 +name: nicotinic acid receptor activity +namespace: molecular_function +def: "Combining with nicotinic acid to initiate a change in cell activity." [GOC:mah, PMID:12522134] +synonym: "niacin receptor activity" EXACT [CHEBI:15940, GOC:mah] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0070554 +name: synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex +namespace: cellular_component +def: "A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof)." [PMID:8824312] +synonym: "SNARE complex (Stx3, Snap25, Vamp2, Cplx1)" NARROW [CORUM:842] +synonym: "Stx3-Snap25-Vamp2-Cplx1 complex" NARROW [CORUM:842] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070555 +name: response to interleukin-1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:BHF, GOC:mah] +synonym: "response to IL-1" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070556 +name: TAF4B-containing transcription factor TFIID complex +namespace: cellular_component +def: "A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4." [GOC:mah, PMID:8858156] +synonym: "TFIID complex, B-cell specific" RELATED [CORUM:485] +is_a: GO:0005669 ! transcription factor TFIID complex + +[Term] +id: GO:0070557 +name: PCNA-p21 complex +namespace: cellular_component +def: "A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication." [GOC:mah, PMID:7911228, PMID:7915843] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070558 +name: alphaM-beta2 integrin-CD63 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family." [PMID:8871662] +synonym: "ITGAM-ITGB2-CD63 complex" NARROW [CORUM:2153] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070559 +name: lysosomal multienzyme complex +namespace: cellular_component +def: "A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism." [GOC:mah, PMID:8910459] +synonym: "GALNS-lysosomal hydrolase 1.27 MDa complex" NARROW [CORUM:1379] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0070560 +name: protein secretion by platelet +namespace: biological_process +def: "The regulated release of proteins by a platelet or group of platelets." [GOC:BHF, GOC:mah] +is_a: GO:0009306 ! protein secretion +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0002576 ! platelet degranulation + +[Term] +id: GO:0070561 +name: vitamin D receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah, PMID:12637589] +synonym: "calcitriol signaling pathway" NARROW [GOC:bf] +synonym: "VDR signaling pathway" EXACT [PMID:12637589] +synonym: "vitamin D receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0030522 ! intracellular receptor signaling pathway +relationship: part_of GO:0071305 ! cellular response to vitamin D + +[Term] +id: GO:0070562 +name: regulation of vitamin D receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] +synonym: "regulation of VDR signaling pathway" EXACT [PMID:12637589] +synonym: "regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0032107 ! regulation of response to nutrient levels +relationship: regulates GO:0070561 ! vitamin D receptor signaling pathway + +[Term] +id: GO:0070563 +name: negative regulation of vitamin D receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] +synonym: "down regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +synonym: "down-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +synonym: "downregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +synonym: "inhibition of vitamin D receptor signaling pathway" NARROW [GOC:mah] +synonym: "negative regulation of VDR signaling pathway" EXACT [GOC:mah] +synonym: "negative regulation of VDR signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation vitamin D receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway +relationship: negatively_regulates GO:0070561 ! vitamin D receptor signaling pathway + +[Term] +id: GO:0070564 +name: positive regulation of vitamin D receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vitamin D receptor signaling pathway activity." [GOC:BHF, GOC:mah] +synonym: "activation of vitamin D receptor signaling pathway" NARROW [GOC:mah] +synonym: "positive regulation of VDR signaling pathway" EXACT [GOC:mah] +synonym: "positive regulation of vitamin D receptor signalling pathway" EXACT [GOC:mah] +synonym: "stimulation of vitamin D receptor signaling pathway" NARROW [GOC:mah] +synonym: "up regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +synonym: "up-regulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +synonym: "upregulation of vitamin D receptor signaling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0070562 ! regulation of vitamin D receptor signaling pathway +relationship: positively_regulates GO:0070561 ! vitamin D receptor signaling pathway + +[Term] +id: GO:0070565 +name: telomere-telomerase complex +namespace: cellular_component +def: "A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome." [GOC:pde, PMID:19179534] +comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. +is_a: GO:0032993 ! protein-DNA complex +relationship: part_of GO:0000781 ! chromosome, telomeric region + +[Term] +id: GO:0070566 +name: adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an adenylyl group to an acceptor." [GOC:mah] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0070567 +name: cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a cytidylyl group to an acceptor." [GOC:mah] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0070568 +name: guanylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a guanylyl group to an acceptor." [GOC:mah] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0070569 +name: uridylyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah] +synonym: "uridyl transferase activity" EXACT [] +synonym: "uridyltransferase activity" EXACT [] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0070570 +name: regulation of neuron projection regeneration +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] +is_a: GO:0010975 ! regulation of neuron projection development +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0031102 ! neuron projection regeneration + +[Term] +id: GO:0070571 +name: negative regulation of neuron projection regeneration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] +synonym: "growth cone collapse" RELATED [GOC:pr] +is_a: GO:0010977 ! negative regulation of neuron projection development +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0070570 ! regulation of neuron projection regeneration +relationship: negatively_regulates GO:0031102 ! neuron projection regeneration + +[Term] +id: GO:0070572 +name: positive regulation of neuron projection regeneration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage." [GOC:mah] +is_a: GO:0010976 ! positive regulation of neuron projection development +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0070570 ! regulation of neuron projection regeneration +relationship: positively_regulates GO:0031102 ! neuron projection regeneration + +[Term] +id: GO:0070573 +name: metallodipeptidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE] +synonym: "metallo-exo-dipeptidase activity" EXACT [GOC:rb] +synonym: "metalloexodipeptidase activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-2022398 "ACE hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)" +xref: Reactome:R-HSA-2022405 "ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" +xref: Reactome:R-HSA-2065355 "Secreted ACE hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" +is_a: GO:0008235 ! metalloexopeptidase activity +is_a: GO:0016805 ! dipeptidase activity + +[Term] +id: GO:0070574 +name: cadmium ion transmembrane transport +namespace: biological_process +def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "cadmium ion membrane transport" EXACT [] +synonym: "transmembrane cadmium transport" EXACT [GOC:mah] +is_a: GO:0015691 ! cadmium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0070575 +name: peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation +namespace: biological_process +def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation." [GOC:mah] +synonym: "peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] +synonym: "peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] +is_a: GO:0007323 ! peptide pheromone maturation +relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation + +[Term] +id: GO:0070576 +name: vitamin D 24-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:mah, PMID:15546903] +synonym: "calciferol 24-hydroxylase activity" NARROW [GOC:rl] +synonym: "cholecalciferol 24-hydroxylase activity" NARROW [GOC:rl] +synonym: "ergocalciferol 24-hydroxylase activity" NARROW [GOC:rl] +synonym: "vitamin D2 24-hydroxylase activity" NARROW [GOC:rl] +synonym: "vitamin D3 24-hydroxylase activity" NARROW [GOC:rl] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0070577 +name: lysine-acetylated histone binding +namespace: molecular_function +def: "Binding to a histone in which a lysine residue has been modified by acetylation." [GOC:BHF, GOC:mah, GOC:rl, PMID:17582821] +synonym: "acetylated histone residue binding" BROAD [GOC:rl] +is_a: GO:0042393 ! histone binding +is_a: GO:0140033 ! acetylation-dependent protein binding + +[Term] +id: GO:0070578 +name: RISC-loading complex +namespace: cellular_component +def: "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710] +synonym: "microRNA loading complex" EXACT [GOC:ab] +synonym: "miRLC" EXACT [GOC:ab] +synonym: "RLC" RELATED [GOC:ab, GOC:mah] +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:0070579 +name: methylcytosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2." [PMID:19372391] +xref: Reactome:R-HSA-5220952 "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine" +xref: Reactome:R-HSA-5220990 "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine" +xref: Reactome:R-HSA-5221014 "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine" +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0070580 +name: base J metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J." [PMID:19114062] +synonym: "base J metabolism" EXACT [GOC:mah] +synonym: "beta-D-glucosyl-HOMedU metabolic process" EXACT [GOC:mah] +synonym: "beta-D-glucosyl-hydroxymethyluracil metabolism" EXACT [PMID:19114062] +is_a: GO:0006304 ! DNA modification + +[Term] +id: GO:0070581 +name: rolling circle DNA replication +namespace: biological_process +def: "A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon." [GOC:cb, GOC:mah, ISBN:0198506732] +synonym: "rolling circle replication" EXACT [GOC:cb] +is_a: GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0070582 +name: theta DNA replication +namespace: biological_process +def: "A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template." [GOC:cb, GOC:mah, ISBN:0198506732] +synonym: "theta replication" EXACT [GOC:cb] +is_a: GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0070583 +name: spore membrane bending pathway +namespace: biological_process +def: "The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore." [GOC:dgf, PMID:18756268] +synonym: "ascospore-type prospore membrane bending" EXACT [GOC:mah] +synonym: "forespore membrane bending" EXACT [GOC:mah] +synonym: "FSM bending" EXACT [GOC:mah] +is_a: GO:0061024 ! membrane organization +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0032120 ! ascospore-type prospore membrane formation + +[Term] +id: GO:0070584 +name: mitochondrion morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mitochondrion are generated and organized." [GOC:mah] +comment: Note that this term is intended for annotation of gene products involved in mitochondrial shape changes associated with development; an example is the morphogenesis of the Nebenkern during spermatogenesis. +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0032990 ! cell part morphogenesis + +[Term] +id: GO:0070585 +name: protein localization to mitochondrion +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] +synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] +synonym: "protein localization in mitochondrion" EXACT [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0070586 +name: cell-cell adhesion involved in gastrulation +namespace: biological_process +def: "The attachment of one cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0007369 ! gastrulation + +[Term] +id: GO:0070587 +name: regulation of cell-cell adhesion involved in gastrulation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation." [GOC:dsf, PMID:19091770] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0070586 ! cell-cell adhesion involved in gastrulation + +[Term] +id: GO:0070588 +name: calcium ion transmembrane transport +namespace: biological_process +def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "calcium ion membrane transport" EXACT [] +synonym: "transmembrane calcium transport" EXACT [GOC:mah] +is_a: GO:0006816 ! calcium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0070589 +name: cellular component macromolecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component." [GOC:mah] +synonym: "cellular component macromolecule biosynthesis" EXACT [GOC:mah] +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +relationship: part_of GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0070590 +name: spore wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah] +is_a: GO:0042546 ! cell wall biogenesis +relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0070591 +name: ascospore wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah] +is_a: GO:0009272 ! fungal-type cell wall biogenesis +is_a: GO:0070590 ! spore wall biogenesis +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0030437 ! ascospore formation + +[Term] +id: GO:0070592 +name: cell wall polysaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall." [GOC:mah] +synonym: "cell wall polysaccharide anabolism" EXACT [GOC:mah] +synonym: "cell wall polysaccharide biosynthesis" EXACT [GOC:mah] +synonym: "cell wall polysaccharide synthesis" EXACT [GOC:mah] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0033692 ! cellular polysaccharide biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process + +[Term] +id: GO:0070593 +name: dendrite self-avoidance +namespace: biological_process +def: "The process in which dendrites recognize and avoid contact with sister dendrites from the same cell." [GOC:sart, PMID:17482551] +synonym: "dendrite repulsion" EXACT [GOC:sart] +is_a: GO:0008038 ! neuron recognition + +[Term] +id: GO:0070594 +name: juvenile hormone response element binding +namespace: molecular_function +def: "Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone." [GOC:sart, PMID:17956872] +synonym: "JHRE binding" EXACT [GOC:mah] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0070595 +name: (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +synonym: "1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0070596 +name: (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan anabolism" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan formation" EXACT [GOC:mah] +synonym: "alpha-1,3 glucan synthesis" EXACT [GOC:mah] +is_a: GO:0030979 ! alpha-glucan biosynthetic process +is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070597 +name: cell wall (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +is_a: GO:0070595 ! (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070598 +name: cell wall (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] +synonym: "cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process +is_a: GO:0070596 ! (1->3)-alpha-glucan biosynthetic process +is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070599 +name: fungal-type cell wall (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "ascospore wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +synonym: "ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process +is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process + +[Term] +id: GO:0070600 +name: fungal-type cell wall (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] +synonym: "fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] +synonym: "fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process +is_a: GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process +is_a: GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070601 +name: centromeric sister chromatid cohesion +namespace: biological_process +def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah] +synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah] +is_a: GO:0007062 ! sister chromatid cohesion + +[Term] +id: GO:0070602 +name: regulation of centromeric sister chromatid cohesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion in the centromeric region of a chromosome." [GOC:mah] +synonym: "regulation of sister chromatid cohesion at centromere" EXACT [GOC:mah] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +relationship: regulates GO:0070601 ! centromeric sister chromatid cohesion + +[Term] +id: GO:0070603 +name: SWI/SNF superfamily-type complex +namespace: cellular_component +alt_id: GO:0090544 +def: "A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP." [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] +subset: gocheck_do_not_manually_annotate +synonym: "BAF-type complex" EXACT [] +synonym: "SWI-SNF global transcription activator complex" RELATED [CORUM:224] +synonym: "SWI-SNF-type complex" EXACT [GOC:mah] +synonym: "SWI/SNF-type complex" RELATED [GOC:krc] +synonym: "SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex" RELATED [GOC:krc] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1904949 ! ATPase complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070605 +name: regulation of (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0032948 ! regulation of alpha-glucan metabolic process +relationship: regulates GO:0070595 ! (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070606 +name: regulation of (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "regulation of 1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan formation" EXACT [GOC:mah] +synonym: "regulation of alpha-1,3 glucan synthesis" EXACT [GOC:mah] +is_a: GO:0032949 ! regulation of alpha-glucan biosynthetic process +is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process +relationship: regulates GO:0070596 ! (1->3)-alpha-glucan biosynthetic process + +[Term] +id: GO:0070607 +name: regulation of cell wall (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0070605 ! regulation of (1->3)-alpha-glucan metabolic process +relationship: regulates GO:0070597 ! cell wall (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070608 +name: regulation of cell wall (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of cells." [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "regulation of cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] +synonym: "regulation of cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0070606 ! regulation of (1->3)-alpha-glucan biosynthetic process +is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process +relationship: regulates GO:0070598 ! cell wall (1->3)-alpha-glucan biosynthetic process + +[Term] +id: GO:0070609 +name: regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-alpha-D-glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in the walls of ascospores." [GOC:mah] +synonym: "regulation of ascospore wall 1,3-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "regulation of ascospore wall alpha-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "regulation of ascospore wall alpha-1,3 glucan metabolism" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan metabolic process" EXACT [GOC:mah] +is_a: GO:0070607 ! regulation of cell wall (1->3)-alpha-glucan metabolic process +relationship: regulates GO:0070599 ! fungal-type cell wall (1->3)-alpha-glucan metabolic process + +[Term] +id: GO:0070610 +name: regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores." [GOC:mah] +synonym: "regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan formation" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall 1,3-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall alpha-1,3-glucan anabolism" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall alpha-1,3-glucan formation" EXACT [GOC:mah] +synonym: "regulation of fungal-type cell wall alpha-1,3-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis +is_a: GO:0070608 ! regulation of cell wall (1->3)-alpha-glucan biosynthetic process +is_a: GO:0070609 ! regulation of fungal-type cell wall (1->3)-alpha-glucan metabolic process +relationship: regulates GO:0070600 ! fungal-type cell wall (1->3)-alpha-glucan biosynthetic process + +[Term] +id: GO:0070611 +name: histone methyltransferase activity (H3-R2 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3." [GOC:mah, PMID:17898714] +synonym: "histone methylase activity (H3-R2 specific)" EXACT [GOC:mah] +synonym: "histone-arginine N-methyltransferase activity (H3-R2 specific)" EXACT [GOC:mah] +is_a: GO:0008469 ! histone-arginine N-methyltransferase activity + +[Term] +id: GO:0070612 +name: histone methyltransferase activity (H2A-R3 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A." [GOC:mah, PMID:17898714] +synonym: "histone methylase activity (H2A-R3 specific)" EXACT [GOC:mah] +synonym: "histone-arginine N-methyltransferase activity (H2A-R3 specific)" EXACT [GOC:mah] +is_a: GO:0008469 ! histone-arginine N-methyltransferase activity + +[Term] +id: GO:0070613 +name: regulation of protein processing +namespace: biological_process +alt_id: GO:0010953 +def: "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GOC:mah] +synonym: "regulation of protein maturation by peptide bond cleavage" EXACT [] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:1903317 ! regulation of protein maturation +relationship: regulates GO:0016485 ! protein processing + +[Term] +id: GO:0070614 +name: tungstate ion transport +namespace: biological_process +def: "The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten." [GOC:dh] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0070616 +name: regulation of thiamine diphosphate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] +synonym: "regulation of thiamin diphosphate biosynthetic process" EXACT [] +synonym: "regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] +synonym: "regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] +synonym: "regulation of thiamine diphosphate formation" EXACT [GOC:mah] +synonym: "regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] +is_a: GO:0019220 ! regulation of phosphate metabolic process +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0009229 ! thiamine diphosphate biosynthetic process + +[Term] +id: GO:0070617 +name: negative regulation of thiamine diphosphate biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate." [GOC:mah] +synonym: "down regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] +synonym: "downregulation of thiamine diphosphate biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of thiamine diphosphate biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of thiamin diphosphate biosynthetic process" EXACT [] +synonym: "negative regulation of thiamine diphosphate anabolism" EXACT [GOC:mah] +synonym: "negative regulation of thiamine diphosphate biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of thiamine diphosphate formation" EXACT [GOC:mah] +synonym: "negative regulation of thiamine diphosphate synthesis" EXACT [GOC:mah] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:0070616 ! regulation of thiamine diphosphate biosynthetic process +relationship: negatively_regulates GO:0009229 ! thiamine diphosphate biosynthetic process + +[Term] +id: GO:0070618 +name: Grb2-Sos complex +namespace: cellular_component +def: "A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] +synonym: "Grb2-mSos1 complex" NARROW [CORUM:2545] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070619 +name: Shc-Grb2-Sos complex +namespace: cellular_component +def: "A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7970708, PMID:8940013] +synonym: "Shc-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2553] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070620 +name: EGFR-Grb2-Sos complex +namespace: cellular_component +def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] +synonym: "Egfr-Grb2-mSos1 complex, EGF stimulated" NARROW [CORUM:2548] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070621 +name: EGFR-Shc-Grb2-Sos complex +namespace: cellular_component +def: "A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway." [GOC:mah, PMID:7798267, PMID:8940013] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070622 +name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex +namespace: cellular_component +def: "A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits." [GOC:mah, PMID:8940155] +synonym: "N-acetylglucosamine-1-phosphotransferase complex" RELATED [CORUM:406] +synonym: "UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex" EXACT [PMID:8940155] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0070623 +name: regulation of thiamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] +synonym: "regulation of thiamin biosynthetic process" EXACT [] +synonym: "regulation of thiamine anabolism" EXACT [GOC:mah] +synonym: "regulation of thiamine biosynthesis" EXACT [GOC:mah] +synonym: "regulation of thiamine formation" EXACT [GOC:mah] +synonym: "regulation of thiamine synthesis" EXACT [GOC:mah] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0009228 ! thiamine biosynthetic process + +[Term] +id: GO:0070624 +name: negative regulation of thiamine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:mah] +synonym: "down regulation of thiamine biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of thiamine biosynthetic process" EXACT [GOC:mah] +synonym: "downregulation of thiamine biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of thiamine biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of thiamin biosynthetic process" EXACT [] +synonym: "negative regulation of thiamine anabolism" EXACT [GOC:mah] +synonym: "negative regulation of thiamine biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of thiamine formation" EXACT [GOC:mah] +synonym: "negative regulation of thiamine synthesis" EXACT [GOC:mah] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:0070623 ! regulation of thiamine biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0009228 ! thiamine biosynthetic process + +[Term] +id: GO:0070625 +name: zymogen granule exocytosis +namespace: biological_process +def: "The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions." [GOC:BHF, GOC:vk, PMID:17442889] +is_a: GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:0070626 +name: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [GOC:mah, GOC:pde] +synonym: "(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity" RELATED [] +synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] +synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] +synonym: "SAICAR-lyase (fumarate forming) activity" RELATED [] +synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] +xref: EC:4.3.2.2 +xref: KEGG_REACTION:R04559 +xref: MetaCyc:AICARSYN-RXN +xref: RHEA:23920 +is_a: GO:0016842 ! amidine-lyase activity + +[Term] +id: GO:0070628 +name: proteasome binding +namespace: molecular_function +def: "Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] +subset: goslim_chembl +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0070629 +name: (1->4)-alpha-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "(1->4)-alpha-D-glucan metabolism" EXACT [GOC:mah] +synonym: "1,4-alpha-D-glucan metabolism" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan metabolism" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan metabolic process" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0030978 ! alpha-glucan metabolic process + +[Term] +id: GO:0070630 +name: (1->4)-alpha-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->4)-alpha-glucans, compounds composed of glucose residues linked by (1->4)-alpha-D-glucosidic bonds." [GOC:mah] +synonym: "(1->4)-alpha-D-glucan anabolism" EXACT [GOC:mah] +synonym: "(1->4)-alpha-D-glucan biosynthesis" EXACT [GOC:mah] +synonym: "(1->4)-alpha-D-glucan formation" EXACT [GOC:mah] +synonym: "(1->4)-alpha-D-glucan synthesis" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan anabolism" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan biosynthesis" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan formation" EXACT [GOC:mah] +synonym: "1,4-alpha-glucan synthesis" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan anabolism" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan biosynthesis" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan biosynthetic process" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan formation" EXACT [GOC:mah] +synonym: "alpha-1,4 glucan synthesis" EXACT [GOC:mah] +is_a: GO:0030979 ! alpha-glucan biosynthetic process +is_a: GO:0070629 ! (1->4)-alpha-glucan metabolic process + +[Term] +id: GO:0070631 +name: spindle pole body localization +namespace: biological_process +alt_id: GO:0071790 +alt_id: GO:1990944 +def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] +synonym: "maintenance of spindle pole body localization" NARROW [] +synonym: "spindle pole body localisation" EXACT [GOC:mah] +is_a: GO:0051641 ! cellular localization +is_a: GO:0061842 ! microtubule organizing center localization + +[Term] +id: GO:0070633 +name: transepithelial transport +namespace: biological_process +def: "The directed movement of a substance from one side of an epithelium to the other." [GOC:mah, GOC:yaf, ISBN:0716731363] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0070634 +name: transepithelial ammonium transport +namespace: biological_process +def: "The directed movement of ammonium ions from one side of an epithelium to the other." [GOC:mah, GOC:yaf] +is_a: GO:0006812 ! cation transport +is_a: GO:0070633 ! transepithelial transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0070635 +name: nicotinamide riboside hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose." [MetaCyc:RXN-8441, PMID:19001417] +synonym: "N-ribosylnicotinamide hydrolase activity" EXACT [CHEBI:15927] +synonym: "nicotinamide ribonucleoside hydrolase activity" EXACT [CHEBI:15927] +xref: MetaCyc:RXN-8441 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0070636 +name: nicotinic acid riboside hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose." [GOC:mah, PMID:19001417] +synonym: "D-ribosylnicotinate hydrolase activity" EXACT [GOC:mah] +synonym: "D-ribosylnicotinic acid hydrolase activity" EXACT [CHEBI:27748] +synonym: "nicotinate ribonucleoside hydrolase activity" EXACT [GOC:mah] +synonym: "nicotinate riboside hydrolase activity" EXACT [GOC:mah] +synonym: "nicotinic acid ribonucleoside hydrolase activity" EXACT [GOC:mah] +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0070637 +name: pyridine nucleoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] +synonym: "pyridine nucleoside metabolism" EXACT [GOC:mah] +is_a: GO:0009116 ! nucleoside metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:0070638 +name: pyridine nucleoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of any pyridine nucleoside, a nucleoside in which a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] +synonym: "pyridine nucleoside breakdown" EXACT [GOC:mah] +synonym: "pyridine nucleoside catabolism" EXACT [GOC:mah] +synonym: "pyridine nucleoside degradation" EXACT [GOC:mah] +is_a: GO:0009164 ! nucleoside catabolic process +is_a: GO:0070637 ! pyridine nucleoside metabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process + +[Term] +id: GO:0070639 +name: vitamin D2 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D2, (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol." [GOC:BHF, GOC:mah] +synonym: "calciferol metabolic process" EXACT [CHEBI:28934] +synonym: "ergocalciferol metabolic process" EXACT [CHEBI:28934] +synonym: "vitamin D2 metabolism" EXACT [GOC:mah] +is_a: GO:0042359 ! vitamin D metabolic process + +[Term] +id: GO:0070640 +name: vitamin D3 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol." [GOC:BHF, GOC:mah] +synonym: "calciol metabolic process" EXACT [CHEBI:28940] +synonym: "cholecalciferol metabolic process" EXACT [CHEBI:28940] +synonym: "vitamin D3 metabolism" EXACT [GOC:mah] +is_a: GO:0042359 ! vitamin D metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:0070641 +name: vitamin D4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D4, (3S,5Z,7E)-9,10-secoergosta-5,7,10(19)-trien-3-ol." [GOC:BHF, GOC:mah] +synonym: "vitamin D4 metabolism" EXACT [GOC:mah] +is_a: GO:0042359 ! vitamin D metabolic process + +[Term] +id: GO:0070642 +name: vitamin D5 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vitamin D5, (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4S)-4-ethyl-1,5-dimethylhexyl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol." [GOC:BHF, GOC:mah, PubChem_Compound:9547700] +synonym: "vitamin D5 metabolism" EXACT [GOC:mah] +is_a: GO:0042359 ! vitamin D metabolic process + +[Term] +id: GO:0070643 +name: vitamin D 25-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the hydroxylation of C-25 of any form of vitamin D." [GOC:BHF, GOC:mah] +synonym: "calciferol 25-hydroxylase activity" NARROW [GOC:mah] +synonym: "cholecalciferol 25-hydroxylase activity" NARROW [GOC:mah] +synonym: "ergocalciferol 25-hydroxylase activity" NARROW [GOC:mah] +synonym: "vitamin D2 25-hydroxylase activity" NARROW [GOC:mah] +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0070644 +name: vitamin D response element binding +namespace: molecular_function +def: "Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:vk, PMID:17426122] +synonym: "VDRE binding" EXACT [GOC:vk, PMID:17426122] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0070645 +name: Ubisch body +namespace: cellular_component +def: "A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development." [GOC:ecd, GOC:mah, PMID:14612572, PMID:16524248] +synonym: "orbicule" EXACT [PMID:14612572] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:0070646 +name: protein modification by small protein removal +namespace: biological_process +def: "A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein." [GOC:mah] +is_a: GO:0006508 ! proteolysis +is_a: GO:0070647 ! protein modification by small protein conjugation or removal + +[Term] +id: GO:0070647 +name: protein modification by small protein conjugation or removal +namespace: biological_process +def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] +subset: goslim_drosophila +subset: goslim_pombe +subset: goslim_yeast +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0070648 +name: formin-nucleated actin cable +namespace: cellular_component +def: "An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth." [PMID:14671023, PMID:16959963] +is_a: GO:0097518 ! parallel actin filament bundle + +[Term] +id: GO:0070649 +name: formin-nucleated actin cable assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:mah, PMID:14671023, PMID:16959963] +synonym: "formin-nucleated actin cable formation" EXACT [GOC:mah] +is_a: GO:0030046 ! parallel actin filament bundle assembly +is_a: GO:0110009 ! formin-nucleated actin cable organization + +[Term] +id: GO:0070650 +name: actin filament bundle distribution +namespace: biological_process +def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah] +is_a: GO:0061572 ! actin filament bundle organization + +[Term] +id: GO:0070651 +name: nonfunctional rRNA decay +namespace: biological_process +def: "An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system." [GOC:mah, GOC:rn, PMID:17188037, PMID:19390089] +synonym: "NRD" RELATED [GOC:rn] +is_a: GO:0016075 ! rRNA catabolic process + +[Term] +id: GO:0070652 +name: HAUS complex +namespace: cellular_component +def: "A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex." [PMID:19427217] +synonym: "HAUS augmin complex" EXACT [GOC:mm2] +is_a: GO:0005875 ! microtubule associated complex + +[Term] +id: GO:0070653 +name: high-density lipoprotein particle receptor binding +namespace: molecular_function +def: "Binding to a high-density lipoprotein receptor." [GOC:BHF, GOC:mah] +synonym: "HDL receptor binding" EXACT [GOC:mah] +synonym: "high-density lipoprotein receptor binding" EXACT [GOC:dph] +is_a: GO:0070325 ! lipoprotein particle receptor binding + +[Term] +id: GO:0070654 +name: sensory epithelium regeneration +namespace: biological_process +def: "The regrowth of a sensory epithelium following its loss or destruction." [GOC:dsf, PMID:19381250] +is_a: GO:1990399 ! epithelium regeneration + +[Term] +id: GO:0070655 +name: mechanosensory epithelium regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed mechanosensory epithelia." [GOC:dsf, PMID:19381250] +is_a: GO:0070654 ! sensory epithelium regeneration + +[Term] +id: GO:0070656 +name: mechanoreceptor differentiation involved in mechanosensory epithelium regeneration +namespace: biological_process +def: "Differentiation of new mechanoreceptors to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] +is_a: GO:0042490 ! mechanoreceptor differentiation +relationship: part_of GO:0070655 ! mechanosensory epithelium regeneration + +[Term] +id: GO:0070657 +name: neuromast regeneration +namespace: biological_process +def: "The regrowth of a neuromast following its loss or destruction." [GOC:dsf, PMID:19381250] +is_a: GO:0070655 ! mechanosensory epithelium regeneration + +[Term] +id: GO:0070658 +name: neuromast hair cell differentiation involved in neuromast regeneration +namespace: biological_process +def: "Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] +is_a: GO:0048886 ! neuromast hair cell differentiation +is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration +relationship: part_of GO:0070657 ! neuromast regeneration + +[Term] +id: GO:0070659 +name: inner ear sensory epithelium regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed inner ear sensory epithelia." [GOC:dsf, PMID:19381250] +is_a: GO:0070655 ! mechanosensory epithelium regeneration + +[Term] +id: GO:0070660 +name: inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration +namespace: biological_process +def: "Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury." [GOC:dsf, PMID:19381250] +is_a: GO:0060113 ! inner ear receptor cell differentiation +is_a: GO:0070656 ! mechanoreceptor differentiation involved in mechanosensory epithelium regeneration +relationship: part_of GO:0070659 ! inner ear sensory epithelium regeneration + +[Term] +id: GO:0070661 +name: leukocyte proliferation +namespace: biological_process +def: "The expansion of a leukocyte population by cell division." [GOC:add] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0070662 +name: mast cell proliferation +namespace: biological_process +def: "The expansion of a mast cell population by cell division." [GOC:add] +is_a: GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0070663 +name: regulation of leukocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0070664 +name: negative regulation of leukocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] +synonym: "down regulation of leukocyte proliferation" EXACT [GOC:mah] +synonym: "down-regulation of leukocyte proliferation" EXACT [GOC:mah] +synonym: "downregulation of leukocyte proliferation" EXACT [GOC:mah] +synonym: "inhibition of leukocyte proliferation" NARROW [GOC:mah] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: negatively_regulates GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0070665 +name: positive regulation of leukocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte proliferation." [GOC:add, GOC:mah] +synonym: "activation of leukocyte proliferation" NARROW [GOC:mah] +synonym: "stimulation of leukocyte proliferation" NARROW [GOC:mah] +synonym: "up regulation of leukocyte proliferation" EXACT [GOC:mah] +synonym: "up-regulation of leukocyte proliferation" EXACT [GOC:mah] +synonym: "upregulation of leukocyte proliferation" EXACT [GOC:mah] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: positively_regulates GO:0070661 ! leukocyte proliferation + +[Term] +id: GO:0070666 +name: regulation of mast cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mast cell proliferation." [GOC:add, GOC:mah] +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: regulates GO:0070662 ! mast cell proliferation + +[Term] +id: GO:0070667 +name: negative regulation of mast cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] +synonym: "down regulation of mast cell proliferation" EXACT [GOC:mah] +synonym: "down-regulation of mast cell proliferation" EXACT [GOC:mah] +synonym: "downregulation of mast cell proliferation" EXACT [GOC:mah] +synonym: "inhibition of mast cell proliferation" NARROW [GOC:mah] +is_a: GO:0070664 ! negative regulation of leukocyte proliferation +is_a: GO:0070666 ! regulation of mast cell proliferation +relationship: negatively_regulates GO:0070662 ! mast cell proliferation + +[Term] +id: GO:0070668 +name: positive regulation of mast cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of mast cell proliferation." [GOC:add, GOC:mah] +synonym: "activation of mast cell proliferation" NARROW [GOC:mah] +synonym: "stimulation of mast cell proliferation" NARROW [GOC:mah] +synonym: "up regulation of mast cell proliferation" EXACT [GOC:mah] +synonym: "up-regulation of mast cell proliferation" EXACT [GOC:mah] +synonym: "upregulation of mast cell proliferation" EXACT [GOC:mah] +is_a: GO:0070665 ! positive regulation of leukocyte proliferation +is_a: GO:0070666 ! regulation of mast cell proliferation +relationship: positively_regulates GO:0070662 ! mast cell proliferation + +[Term] +id: GO:0070669 +name: response to interleukin-2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] +synonym: "response to IL-2" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070670 +name: response to interleukin-4 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] +synonym: "response to IL-4" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070671 +name: response to interleukin-12 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] +synonym: "response to IL-12" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070672 +name: response to interleukin-15 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] +synonym: "response to IL-15" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070673 +name: response to interleukin-18 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] +synonym: "response to IL-18" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070674 +name: hypoxanthine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+." [GOC:mah, GOC:pde] +synonym: "hypoxanthine oxidoreductase activity" BROAD [EC:1.17.1.4] +synonym: "hypoxanthine-NAD oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "hypoxanthine/NAD(+) oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "hypoxanthine/NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "hypoxanthine:NAD+ oxidoreductase activity" RELATED [EC:1.17.1.4] +synonym: "NAD-hypoxanthine dehydrogenase activity" RELATED [EC:1.17.1.4] +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0070675 +name: hypoxanthine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2." [GOC:mah, GOC:pde] +synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] +synonym: "hypoxanthine:O(2) oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "hypoxanthine:O2 oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "hypoxanthine:oxygen oxidoreductase activity" RELATED [EC:1.17.3.2] +synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] +synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] +synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] +is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor + +[Term] +id: GO:0070676 +name: intralumenal vesicle formation +namespace: biological_process +def: "The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome." [GOC:jp, PMID:19234443] +synonym: "endosome membrane budding" EXACT [GOC:jp, GOC:mah] +is_a: GO:0006900 ! vesicle budding from membrane +is_a: GO:0007032 ! endosome organization + +[Term] +id: GO:0070677 +name: rRNA (cytosine-2'-O-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine." [GOC:mah, PMID:19400805] +is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0070678 +name: preprotein binding +namespace: molecular_function +def: "Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing." [GOC:imk, GOC:mah, PMID:12914940] +synonym: "unprocessed protein binding" EXACT [GOC:imk] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070679 +name: inositol 1,4,5 trisphosphate binding +namespace: molecular_function +def: "Binding to inositol 1,4,5 trisphosphate." [GOC:BHF, GOC:mah] +synonym: "InsP3 binding" EXACT [GOC:mah] +synonym: "IP3 binding" EXACT [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:0070680 +name: asparaginyl-tRNAAsn biosynthesis via transamidation +namespace: biological_process +def: "A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase." [GOC:mah, MetaCyc:PWY490-4] +xref: MetaCyc:PWY490-4 +is_a: GO:0043039 ! tRNA aminoacylation + +[Term] +id: GO:0070681 +name: glutaminyl-tRNAGln biosynthesis via transamidation +namespace: biological_process +def: "A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase." [GOC:mah, MetaCyc:PWY-5921] +xref: MetaCyc:PWY-5921 +is_a: GO:0043039 ! tRNA aminoacylation + +[Term] +id: GO:0070682 +name: proteasome regulatory particle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex." [GOC:mah, GOC:rb, PMID:19412159] +synonym: "proteasome regulatory complex assembly" EXACT [GOC:mah] +is_a: GO:0043248 ! proteasome assembly + +[Term] +id: GO:0070684 +name: seminal clot liquefaction +namespace: biological_process +def: "The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa." [GOC:mah, PMID:18482984] +synonym: "semen liquefaction" EXACT [PMID:18482984] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0007320 ! insemination + +[Term] +id: GO:0070685 +name: macropinocytic cup +namespace: cellular_component +def: "A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin." [PMID:12538772, PMID:16968738, PMID:9044041] +synonym: "crown" EXACT [GOC:pf, PMID:9044041] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0070686 +name: macropinocytic cup membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a macropinocytic cup." [GOC:mah] +synonym: "crown membrane" EXACT [GOC:mah] +is_a: GO:0031253 ! cell projection membrane +relationship: part_of GO:0070685 ! macropinocytic cup + +[Term] +id: GO:0070687 +name: macropinocytic cup cytoskeleton +namespace: cellular_component +def: "The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup." [GOC:mah] +synonym: "crown cytoskeleton" EXACT [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030864 ! cortical actin cytoskeleton +relationship: part_of GO:0070685 ! macropinocytic cup + +[Term] +id: GO:0070688 +name: obsolete MLL5-L complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that can methylate lysine-4 of histone H3 and plays an essential role in retinoic-acid-induced granulopoiesis. MLL5 is the catalytic methyltransferase subunit, and the complex also contains serine/threonine kinase 38 (STK38), protein phosphatase 1 catalytic subunits, the host cell factor-1 N-terminal subunit, beta-actin, and O-GlcNAc transferase; the human genes encoding the subunits are MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT, respectively." [GOC:mah, PMID:19377461] +comment: This term was made obsolete because there is no evidence for the existence of this complex. +is_obsolete: true + +[Term] +id: GO:0070689 +name: L-threonine catabolic process to propionate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate." [GOC:bf, GOC:mah, MetaCyc:PWY-5437] +synonym: "L-threonine breakdown to propionate" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine catabolism to propionate" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine degradation to propionate" EXACT [GOC:bf, GOC:mah] +synonym: "threonine catabolic process to propionate" BROAD [GOC:bf] +xref: MetaCyc:PWY-5437 +is_a: GO:0006567 ! threonine catabolic process +is_a: GO:0019541 ! propionate metabolic process + +[Term] +id: GO:0070690 +name: L-threonine catabolic process to acetyl-CoA +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA." [GOC:bf, GOC:mah, MetaCyc:PWY-5436] +synonym: "L-threonine breakdown to acetyl-CoA" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine catabolism to acetyl-CoA" EXACT [GOC:bf, GOC:mah] +synonym: "L-threonine degradation to acetyl-CoA" EXACT [GOC:bf, GOC:mah] +synonym: "threonine catabolic process to acetyl-CoA" BROAD [GOC:bf] +xref: MetaCyc:PWY-5436 +is_a: GO:0006084 ! acetyl-CoA metabolic process +is_a: GO:0006567 ! threonine catabolic process + +[Term] +id: GO:0070691 +name: P-TEFb complex +namespace: cellular_component +def: "A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067, Wikipedia:P-TEFb] +synonym: "Bur1/Bur2 complex" NARROW [PMID:16721054, PMID:19328067] +synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex" NARROW [GOC:vw] +synonym: "cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex" NARROW [GOC:bhm] +synonym: "dimeric positive transcription elongation factor complex b" RELATED [] +synonym: "Sgv1/Bur2 complex" NARROW [GOC:mah] +is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex + +[Term] +id: GO:0070692 +name: CTDK-1 complex +namespace: cellular_component +def: "A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638)." [GOC:mah, GOC:vw, PMID:16721054, PMID:19328067] +synonym: "C-terminal domain kinase I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067] +synonym: "CTDK-I complex" EXACT [PMID:15047695, PMID:16721054, PMID:19328067] +synonym: "Ctk complex" EXACT [PMID:16721054] +synonym: "trimeric positive transcription elongation factor complex b" RELATED [] +is_a: GO:0008024 ! cyclin/CDK positive transcription elongation factor complex + +[Term] +id: GO:0070693 +name: P-TEFb-cap methyltransferase complex +namespace: cellular_component +def: "A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase." [PMID:17332744, PMID:19328067] +synonym: "Cdk9-Pcm1 complex" NARROW [GOC:vw] +synonym: "P-TEFb-Pcm1 complex" NARROW [GOC:vw] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070694 +name: deoxyribonucleoside 5'-monophosphate N-glycosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base." [GOC:ab, PMID:17234634] +synonym: "deoxynucleoside 5'-monophosphate N-glycosidase activity" EXACT [] +xref: Reactome:R-HSA-8953339 "DNPH1 hydrolyses dGMP" +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0070695 +name: FHF complex +namespace: cellular_component +def: "A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex)." [GOC:ab, GOC:mah, PMID:18799622] +comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070696 +name: transmembrane receptor protein serine/threonine kinase binding +namespace: molecular_function +def: "Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] +is_a: GO:0033612 ! receptor serine/threonine kinase binding + +[Term] +id: GO:0070697 +name: activin receptor binding +namespace: molecular_function +def: "Binding to an activin receptor." [GOC:BHF, GOC:vk] +is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding + +[Term] +id: GO:0070698 +name: type I activin receptor binding +namespace: molecular_function +def: "Binding to a type I activin receptor." [GOC:BHF, GOC:vk] +is_a: GO:0070697 ! activin receptor binding + +[Term] +id: GO:0070699 +name: type II activin receptor binding +namespace: molecular_function +def: "Binding to a type II activin receptor." [GOC:BHF, GOC:vk] +is_a: GO:0070697 ! activin receptor binding + +[Term] +id: GO:0070700 +name: BMP receptor binding +namespace: molecular_function +def: "Binding to a BMP receptor." [GOC:BHF, GOC:vk] +synonym: "bone morphogenetic protein receptor binding" EXACT [GOC:mah] +is_a: GO:0070696 ! transmembrane receptor protein serine/threonine kinase binding + +[Term] +id: GO:0070701 +name: mucus layer +namespace: cellular_component +def: "An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes." [GOC:krc, GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394, Wikipedia:Mucin] +synonym: "extracellular proteinaceous gel" BROAD [] +synonym: "mucous" EXACT [] +synonym: "mucous layer" EXACT [] +synonym: "mucus" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region + +[Term] +id: GO:0070702 +name: inner mucus layer +namespace: cellular_component +def: "The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] +is_a: GO:0070701 ! mucus layer + +[Term] +id: GO:0070703 +name: outer mucus layer +namespace: cellular_component +def: "The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria." [GOC:mah, GOC:mm2, PMID:18806221, PMID:19432394] +is_a: GO:0070701 ! mucus layer + +[Term] +id: GO:0070704 +name: sterol desaturase activity +namespace: molecular_function +def: "Catalysis of the introduction of a double bond into a sterol molecule." [GOC:mah, GOC:vw] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0070705 +name: RNA nucleotide insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of one or more nucleotides." [GOC:cb, GOC:mah] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0070706 +name: RNA nucleotide deletion +namespace: biological_process +def: "The modification of an RNA molecule by removal of a single nucleotide." [GOC:cb, GOC:mah] +synonym: "RNA nucleotide excision" EXACT [GOC:cb, GOC:mah] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:0070707 +name: RNA dinucleotide insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of a dinucleotide." [GOC:cb, GOC:mah] +is_a: GO:0070705 ! RNA nucleotide insertion + +[Term] +id: GO:0070708 +name: RNA cytidine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of a cytidine nucleotide." [GOC:cb, GOC:mah] +synonym: "RNA C insertion" EXACT [GOC:mah] +is_a: GO:0070705 ! RNA nucleotide insertion + +[Term] +id: GO:0070709 +name: RNA guanosine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of a guanosine nucleotide." [GOC:cb, GOC:mah] +synonym: "RNA G insertion" EXACT [GOC:mah] +is_a: GO:0070705 ! RNA nucleotide insertion + +[Term] +id: GO:0070710 +name: RNA uridine deletion +namespace: biological_process +def: "The modification of an RNA molecule by removal of a uridine nucleotide." [GOC:cb, GOC:mah] +synonym: "RNA U deletion" EXACT [GOC:mah] +synonym: "RNA uridine excision" EXACT [GOC:cb, GOC:mah] +is_a: GO:0070706 ! RNA nucleotide deletion + +[Term] +id: GO:0070711 +name: RNA adenosine-uridine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide." [GOC:cb, GOC:mah] +synonym: "RNA AU insertion" EXACT [GOC:mah] +is_a: GO:0070707 ! RNA dinucleotide insertion + +[Term] +id: GO:0070712 +name: RNA cytidine-uridine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide." [GOC:cb, GOC:mah] +synonym: "RNA CU insertion" EXACT [GOC:mah] +is_a: GO:0070707 ! RNA dinucleotide insertion + +[Term] +id: GO:0070713 +name: RNA guanosine-cytidine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide." [GOC:cb, GOC:mah] +synonym: "RNA GC insertion" EXACT [GOC:mah] +is_a: GO:0070707 ! RNA dinucleotide insertion + +[Term] +id: GO:0070714 +name: RNA guanosine-uridine insertion +namespace: biological_process +def: "The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide." [GOC:cb, GOC:mah] +synonym: "RNA GU insertion" EXACT [GOC:mah] +is_a: GO:0070707 ! RNA dinucleotide insertion + +[Term] +id: GO:0070715 +name: sodium-dependent organic cation transport +namespace: biological_process +def: "The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] +is_a: GO:0015695 ! organic cation transport + +[Term] +id: GO:0070716 +name: mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication +namespace: biological_process +def: "A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication." [GOC:BHF, GOC:mah] +synonym: "mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] +is_a: GO:0006298 ! mismatch repair +relationship: part_of GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity + +[Term] +id: GO:0070717 +name: poly-purine tract binding +namespace: molecular_function +def: "Binding to a stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] +is_a: GO:0003727 ! single-stranded RNA binding + +[Term] +id: GO:0070718 +name: alphaPDGFR-SHP-2 complex +namespace: cellular_component +def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] +synonym: "PDGFRA-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3183] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070719 +name: alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex +namespace: cellular_component +def: "A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] +synonym: "PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated" NARROW [CORUM:2551] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070720 +name: Grb2-SHP-2 complex +namespace: cellular_component +def: "A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway." [GOC:mah, PMID:8943348] +synonym: "GRB2-SHP-2 complex, PDGF stimulated" NARROW [CORUM:3186] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070721 +name: ISGF3 complex +namespace: cellular_component +def: "A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein." [GOC:mah, PMID:8943351] +synonym: "interferon-stimulated gene factor 3 transcription complex" EXACT [CORUM:60] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0070722 +name: Tle3-Aes complex +namespace: cellular_component +def: "A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product." [GOC:mah, PMID:8955148] +synonym: "Grg3b-Grg5 complex" EXACT [CORUM:3130, PMID:8955148] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:0070723 +name: response to cholesterol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:BHF, GOC:vk] +is_a: GO:0036314 ! response to sterol +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0070724 +name: BMP receptor complex +namespace: cellular_component +def: "A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits." [GOC:mah, GOC:mh, PMID:19377468] +synonym: "bone morphogenetic protein receptor complex" EXACT [GOC:mah] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0070725 +name: Yb body +namespace: cellular_component +def: "A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell." [GOC:sart, PMID:19433453] +is_a: GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0070726 +name: cell wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0071555 ! cell wall organization +relationship: part_of GO:0042546 ! cell wall biogenesis + +[Term] +id: GO:0070727 +name: cellular macromolecule localization +namespace: biological_process +def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] +synonym: "cellular macromolecule localisation" EXACT [GOC:mah] +is_a: GO:0033036 ! macromolecule localization +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0070728 +name: leucine binding +namespace: molecular_function +def: "Binding to 2-amino-4-methylpentanoic acid." [GOC:BHF, GOC:mah] +synonym: "Leu binding" EXACT [GOC:mah] +is_a: GO:0016597 ! amino acid binding + +[Term] +id: GO:0070729 +name: cyclic nucleotide transport +namespace: biological_process +def: "The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell." [GOC:mah, ISBN:0198506732] +is_a: GO:0006862 ! nucleotide transport + +[Term] +id: GO:0070730 +name: cAMP transport +namespace: biological_process +def: "The directed movement of cyclic AMP (cAMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732] +synonym: "cyclic AMP transport" EXACT [GOC:mah] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:0070729 ! cyclic nucleotide transport + +[Term] +id: GO:0070731 +name: cGMP transport +namespace: biological_process +def: "The directed movement of cyclic GMP (cGMP), into, out of or within a cell." [GOC:mah, ISBN:0198506732] +synonym: "cyclic GMP transport" EXACT [GOC:mah] +is_a: GO:0001408 ! guanine nucleotide transport +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0070729 ! cyclic nucleotide transport + +[Term] +id: GO:0070732 +name: spindle envelope +namespace: cellular_component +def: "An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase." [GOC:mah, GOC:sart, PMID:19417004, PMID:6428889] +subset: goslim_candida +is_a: GO:0031967 ! organelle envelope + +[Term] +id: GO:0070733 +name: protein adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins." [GOC:mah, PMID:19039103, PMID:19362538] +synonym: "adenosine monophosphate-protein transferase activity" EXACT [GOC:mah] +synonym: "AMPylator" RELATED [GOC:mah] +xref: EC:2.7.7.n1 +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0070734 +name: histone H3-K27 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone." [GOC:mah, GOC:pr] +synonym: "histone H3 K27 methylation" EXACT [GOC:mah] +synonym: "histone H3K27me" EXACT [GOC:mah] +synonym: "histone lysine H3 K27 methylation" EXACT [GOC:mah] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0070735 +name: protein-glycine ligase activity +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein." [GOC:mah, PMID:19524510] +synonym: "protein glycylase activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-8867370 "TTLL3, TTLL8, TTLL10 polyglycylate tubulin" +is_a: GO:0016881 ! acid-amino acid ligase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0070736 +name: protein-glycine ligase activity, initiating +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein." [GOC:mah, PMID:19524510] +synonym: "protein glycylase activity, initiating" EXACT [GOC:mah] +is_a: GO:0070735 ! protein-glycine ligase activity + +[Term] +id: GO:0070737 +name: protein-glycine ligase activity, elongating +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain." [GOC:mah, PMID:19524510] +synonym: "protein glycylase activity, elongating" EXACT [GOC:mah] +is_a: GO:0070735 ! protein-glycine ligase activity + +[Term] +id: GO:0070738 +name: tubulin-glycine ligase activity +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin." [GOC:mah, PMID:19524510] +synonym: "tubulin glycylase activity" EXACT [GOC:mah] +is_a: GO:0070735 ! protein-glycine ligase activity + +[Term] +id: GO:0070739 +name: protein-glutamic acid ligase activity +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein." [GOC:mah, PMID:19524510] +synonym: "protein glutamylase activity" EXACT [GOC:mah] +synonym: "protein-glutamate ligase activity" EXACT [GOC:mah] +is_a: GO:0016881 ! acid-amino acid ligase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0070740 +name: tubulin-glutamic acid ligase activity +namespace: molecular_function +def: "Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule." [GOC:mah, PMID:19524510] +synonym: "tubulin glutamylase activity" EXACT [GOC:mah] +synonym: "tubulin-glutamate ligase activity" EXACT [GOC:mah] +xref: Reactome:R-HSA-8865774 "TTLLs polyglutamylate tubulin" +xref: Reactome:R-HSA-8955869 "Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin" +is_a: GO:0070739 ! protein-glutamic acid ligase activity + +[Term] +id: GO:0070741 +name: response to interleukin-6 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] +synonym: "response to IL-6" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0070742 +name: C2H2 zinc finger domain binding +namespace: molecular_function +def: "Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion." [GOC:BHF, GOC:mah, Pfam:PF00096] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070743 +name: interleukin-23 complex +namespace: cellular_component +def: "A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." [GOC:add, PMID:11114383, PMID:15999093] +comment: Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12. +synonym: "IL-23 complex" EXACT [GOC:add] +synonym: "IL12B" NARROW [GOC:add] +synonym: "IL23A" NARROW [GOC:add] +synonym: "p19" NARROW [GOC:add] +synonym: "p40" NARROW [GOC:add] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0070744 +name: interleukin-27 complex +namespace: cellular_component +def: "A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:15999093, PMID:19161428] +comment: Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits. +synonym: "EBI3" NARROW [GOC:add] +synonym: "IL-27 complex" EXACT [GOC:add] +synonym: "IL27" NARROW [GOC:add] +synonym: "p28" NARROW [GOC:add] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0070745 +name: interleukin-35 complex +namespace: cellular_component +def: "A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space." [GOC:add, PMID:19161428, PMID:19161429] +comment: Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene. +synonym: "EBI3" NARROW [GOC:add] +synonym: "IL-35 complex" EXACT [GOC:add] +synonym: "IL12A" NARROW [GOC:add] +synonym: "p35" NARROW [GOC:add] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0070746 +name: interleukin-35 binding +namespace: molecular_function +def: "Binding to interleukin-35." [GOC:add] +synonym: "IL-35 binding" EXACT [GOC:add] +is_a: GO:0019955 ! cytokine binding + +[Term] +id: GO:0070747 +name: interleukin-35 receptor activity +namespace: molecular_function +def: "Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling] +synonym: "IL-35 receptor activity" EXACT [GOC:add] +synonym: "IL-35R" EXACT [GOC:add] +is_a: GO:0004896 ! cytokine receptor activity + +[Term] +id: GO:0070748 +name: interleukin-35 receptor binding +namespace: molecular_function +def: "Binding to an interleukin-35 receptor." [GOC:add] +synonym: "IL-35" NARROW [GOC:add] +synonym: "interleukin-35 receptor ligand" NARROW [GOC:add] +is_a: GO:0005126 ! cytokine receptor binding + +[Term] +id: GO:0070753 +name: interleukin-35 production +namespace: biological_process +alt_id: GO:0070749 +alt_id: GO:0072626 +def: "The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] +subset: gocheck_do_not_annotate +synonym: "IL-35 production" EXACT [GOC:add] +synonym: "interleukin-35 biosynthetic process" NARROW [] +synonym: "interleukin-35 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0070754 +name: regulation of interleukin-35 production +namespace: biological_process +alt_id: GO:0070750 +def: "Any process that modulates the frequency, rate, or extent of interleukin-35 production." [GOC:mah] +synonym: "regulation of IL-35 production" EXACT [GOC:add] +synonym: "regulation of interleukin-35 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0070753 ! interleukin-35 production + +[Term] +id: GO:0070755 +name: negative regulation of interleukin-35 production +namespace: biological_process +alt_id: GO:0070751 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production." [GOC:mah] +synonym: "down regulation of interleukin-35 production" EXACT [GOC:mah] +synonym: "down-regulation of interleukin-35 production" EXACT [GOC:mah] +synonym: "downregulation of interleukin-35 production" EXACT [GOC:mah] +synonym: "inhibition of interleukin-35 production" NARROW [GOC:mah] +synonym: "negative regulation of IL-35 production" EXACT [GOC:add] +synonym: "negative regulation of interleukin-35 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0070754 ! regulation of interleukin-35 production +relationship: negatively_regulates GO:0070753 ! interleukin-35 production + +[Term] +id: GO:0070756 +name: positive regulation of interleukin-35 production +namespace: biological_process +alt_id: GO:0070752 +def: "Any process that activates or increases the frequency, rate, or extent of interleukin-35 production." [GOC:mah] +synonym: "activation of interleukin-35 production" NARROW [GOC:mah] +synonym: "positive regulation of IL-35 production" EXACT [GOC:add] +synonym: "positive regulation of interleukin-35 biosynthetic process" NARROW [] +synonym: "stimulation of interleukin-35 production" NARROW [GOC:mah] +synonym: "up regulation of interleukin-35 production" EXACT [GOC:mah] +synonym: "up-regulation of interleukin-35 production" EXACT [GOC:mah] +synonym: "upregulation of interleukin-35 production" EXACT [GOC:mah] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0070754 ! regulation of interleukin-35 production +relationship: positively_regulates GO:0070753 ! interleukin-35 production + +[Term] +id: GO:0070757 +name: interleukin-35-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:add, GOC:mah, GOC:signaling] +synonym: "IL-35-mediated signaling pathway" EXACT [GOC:add] +synonym: "interleukin-35-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0070758 +name: regulation of interleukin-35-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35-mediated binding to a cell surface receptor." [GOC:mah] +synonym: "regulation of IL-35-mediated signaling pathway" EXACT [GOC:mah] +synonym: "regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0070757 ! interleukin-35-mediated signaling pathway + +[Term] +id: GO:0070759 +name: negative regulation of interleukin-35-mediated signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] +synonym: "negative regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] +synonym: "negative regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway +relationship: negatively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway + +[Term] +id: GO:0070760 +name: positive regulation of interleukin-35-mediated signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor." [GOC:mah] +synonym: "positive regulation of IL-35-mediated signaling pathway" EXACT [GOC:add] +synonym: "positive regulation of interleukin-35-mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0070758 ! regulation of interleukin-35-mediated signaling pathway +relationship: positively_regulates GO:0070757 ! interleukin-35-mediated signaling pathway + +[Term] +id: GO:0070761 +name: pre-snoRNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes." [GOC:BHF, GOC:mah, GOC:rl, PMID:17636026, PMID:17709390] +synonym: "pre-small nucleolar ribonucleoprotein complex" EXACT [GOC:rl] +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0070762 +name: nuclear pore transmembrane ring +namespace: cellular_component +def: "A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] +synonym: "NDC1 complex" EXACT [] +synonym: "NDC1 subcomplex" EXACT [PMID:19414609] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:0070763 +name: Delta1 complex +namespace: cellular_component +def: "A protein complex that consists of homodimer of the Notch ligand Delta1." [PMID:12794186] +synonym: "Delta1 homodimer complex" EXACT [CORUM:3271] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070764 +name: gamma-secretase-Delta1 complex +namespace: cellular_component +def: "A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex." [PMID:12794186] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070765 +name: gamma-secretase complex +namespace: cellular_component +def: "A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437] +synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142] +synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466] +synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468] +synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" NARROW [CORUM:3128] +synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467] +synonym: "presenilin complex" EXACT [] +synonym: "PS1 complex" NARROW [] +synonym: "PS2 complex" NARROW [] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070766 +name: endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex +namespace: cellular_component +def: "A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof)." [PMID:8973549] +synonym: "SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2)" NARROW [CORUM:1876] +synonym: "Stx4-Napa-Vamp3-Nsf-Vamp2 complex" NARROW [CORUM:1876] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070767 +name: BRCA1-Rad51 complex +namespace: cellular_component +def: "A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity." [GOC:mah, PMID:9008167] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070768 +name: synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex +namespace: cellular_component +def: "A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof)." [PMID:8999968] +synonym: "Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex" NARROW [CORUM:1873] +synonym: "SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a)" NARROW [CORUM:1873] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0070769 +name: alphaIIb-beta3 integrin-CIB complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin." [PMID:9030514] +synonym: "ITGA2B-ITGB3-CIB1 complex" NARROW [CORUM:2379] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070770 +name: alphaIIb-beta3 integrin-CD47-FAK complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK." [PMID:9169439] +synonym: "ITGA2b-ITGB3-CD47-FAK complex" NARROW [CORUM:2896] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070771 +name: alphaIIb-beta3 integrin-CD47-Src complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src." [PMID:9169439] +synonym: "ITGA2b-ITGB3-CD47-SRC complex" NARROW [CORUM:2377] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0070772 +name: PAS complex +namespace: cellular_component +def: "A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p." [PMID:18950639, PMID:19037259, PMID:19158662] +synonym: "autophagy-specific phosphatidylinositol 3-kinase complex" RELATED [PMID:24165940] +is_a: GO:0035032 ! phosphatidylinositol 3-kinase complex, class III +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0070773 +name: protein-N-terminal glutamine amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein." [PMID:19560421] +synonym: "NtQ-amidase activity" EXACT [PMID:19560421] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0070774 +name: phytoceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine." [GOC:pde, PMID:11356846] +xref: KEGG_REACTION:R06528 +xref: MetaCyc:CERAMIDASE-YEAST-RXN +xref: Reactome:R-HSA-428262 "phytoceramide + H2O => stearate + phytosphingosine" +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! N-acylsphingosine amidohydrolase activity + +[Term] +id: GO:0070775 +name: H3 histone acetyltransferase complex +namespace: cellular_component +def: "A multisubunit complex that catalyzes the acetylation of histone H3." [GOC:mah] +synonym: "H3 HAT complex" EXACT [GOC:mah] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:0070776 +name: MOZ/MORF histone acetyltransferase complex +namespace: cellular_component +def: "A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3." [PMID:18794358] +is_a: GO:0070775 ! H3 histone acetyltransferase complex + +[Term] +id: GO:0070777 +name: D-aspartate transport +namespace: biological_process +def: "The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, GOC:rph] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0042940 ! D-amino acid transport + +[Term] +id: GO:0070778 +name: L-aspartate transmembrane transport +namespace: biological_process +alt_id: GO:0089712 +def: "The directed movement of L-aspartate across a membrane." [PMID:21307582] +synonym: "L-aspartate transport" BROAD [] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0070779 +name: D-aspartate import across plasma membrane +namespace: biological_process +alt_id: GO:0140016 +def: "The directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:7914198] +synonym: "D-aspartate import" BROAD [] +synonym: "D-aspartate import into cell" EXACT [] +synonym: "D-aspartate uptake" EXACT [GOC:mah] +is_a: GO:0070777 ! D-aspartate transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0070780 +name: dihydrosphingosine-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate." [GOC:pde, PMID:12815058] +synonym: "dihydrosphingosine-1-phosphate phosphohydrolase activity" EXACT [GOC:mah] +synonym: "sphinganine-1-phosphate phosphatase activity" EXACT [GOC:mah] +xref: MetaCyc:RXN3DJ-25 +xref: Reactome:R-HSA-428664 "sphinganine 1-phosphate + H2O => sphinganine + orthophosphate" +xref: RHEA:27514 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0070781 +name: response to biotin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:sl] +synonym: "response to Bios IIB" EXACT [GOC:sl] +synonym: "response to coenzyme R" EXACT [GOC:sl] +synonym: "response to vitamin B7" EXACT [GOC:sl] +synonym: "response to vitamin H" EXACT [GOC:sl] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033273 ! response to vitamin +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0070782 +name: phosphatidylserine exposure on apoptotic cell surface +namespace: biological_process +def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity." [GOC:mah, GOC:mtg_apoptosis, GOC:rk, PMID:11536005] +comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure. +synonym: "externalization of phosphatidylserine" EXACT [GOC:rk] +is_a: GO:0017121 ! plasma membrane phospholipid scrambling +relationship: part_of GO:0097194 ! execution phase of apoptosis + +[Term] +id: GO:0070783 +name: growth of unicellular organism as a thread of attached cells +namespace: biological_process +def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc] +subset: goslim_candida +is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:0070784 +name: regulation of growth of unicellular organism as a thread of attached cells +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0070785 +name: negative regulation of growth of unicellular organism as a thread of attached cells +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms +relationship: negatively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0070786 +name: positive regulation of growth of unicellular organism as a thread of attached cells +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium." [GOC:mah] +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +relationship: positively_regulates GO:0070783 ! growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0070787 +name: conidiophore development +namespace: biological_process +def: "The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [PMID:9529886] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0070788 +name: conidiophore stalk development +namespace: biological_process +def: "The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [PMID:9529886] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0070787 ! conidiophore development + +[Term] +id: GO:0070789 +name: metula development +namespace: biological_process +def: "The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [PMID:9529886] +synonym: "development of primary sterigmata" EXACT [PMID:9529886] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048468 ! cell development +relationship: part_of GO:0070787 ! conidiophore development + +[Term] +id: GO:0070790 +name: phialide development +namespace: biological_process +def: "The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips." [PMID:9529886] +synonym: "development of secondary sterigmata" EXACT [PMID:9529886] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048468 ! cell development +relationship: part_of GO:0070787 ! conidiophore development + +[Term] +id: GO:0070791 +name: cleistothecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [ISBN:0471522295, PMID:17446882] +is_a: GO:0000909 ! sporocarp development involved in sexual reproduction + +[Term] +id: GO:0070792 +name: Hulle cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [PMID:19210625] +synonym: "Huelle cell development" EXACT [GOC:mah] +synonym: "Hulle cell formation" NARROW [PMID:19210625] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048468 ! cell development +relationship: part_of GO:0070791 ! cleistothecium development + +[Term] +id: GO:0070793 +name: regulation of conidiophore development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0070787 ! conidiophore development + +[Term] +id: GO:0070794 +name: negative regulation of conidiophore development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] +is_a: GO:0070793 ! regulation of conidiophore development +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +relationship: negatively_regulates GO:0070787 ! conidiophore development + +[Term] +id: GO:0070795 +name: positive regulation of conidiophore development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores." [GOC:mah] +is_a: GO:0070793 ! regulation of conidiophore development +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +relationship: positively_regulates GO:0070787 ! conidiophore development + +[Term] +id: GO:0070796 +name: regulation of cleistothecium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] +is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction +relationship: regulates GO:0070791 ! cleistothecium development + +[Term] +id: GO:0070797 +name: negative regulation of cleistothecium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] +is_a: GO:0070796 ! regulation of cleistothecium development +is_a: GO:1902059 ! negative regulation of sporocarp development involved in sexual reproduction +relationship: negatively_regulates GO:0070791 ! cleistothecium development + +[Term] +id: GO:0070798 +name: positive regulation of cleistothecium development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella." [GOC:mah] +is_a: GO:0070796 ! regulation of cleistothecium development +is_a: GO:1902060 ! positive regulation of sporocarp development involved in sexual reproduction +relationship: positively_regulates GO:0070791 ! cleistothecium development + +[Term] +id: GO:0070799 +name: regulation of conidiophore stalk development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0070788 ! conidiophore stalk development + +[Term] +id: GO:0070800 +name: negative regulation of conidiophore stalk development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0070799 ! regulation of conidiophore stalk development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0070788 ! conidiophore stalk development + +[Term] +id: GO:0070801 +name: positive regulation of conidiophore stalk development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop." [GOC:mah] +is_a: GO:0070795 ! positive regulation of conidiophore development +is_a: GO:0070799 ! regulation of conidiophore stalk development +relationship: positively_regulates GO:0070788 ! conidiophore stalk development + +[Term] +id: GO:0070802 +name: regulation of metula development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:0070793 ! regulation of conidiophore development +relationship: regulates GO:0070789 ! metula development + +[Term] +id: GO:0070803 +name: negative regulation of metula development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0070802 ! regulation of metula development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0070789 ! metula development + +[Term] +id: GO:0070804 +name: positive regulation of metula development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip." [GOC:mah] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0070802 ! regulation of metula development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0070789 ! metula development + +[Term] +id: GO:0070805 +name: regulation of phialide development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0070790 ! phialide development + +[Term] +id: GO:0070806 +name: negative regulation of phialide development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0070794 ! negative regulation of conidiophore development +is_a: GO:0070805 ! regulation of phialide development +relationship: negatively_regulates GO:0070790 ! phialide development + +[Term] +id: GO:0070807 +name: positive regulation of phialide development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." [GOC:mah] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0070805 ! regulation of phialide development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0070790 ! phialide development + +[Term] +id: GO:0070808 +name: regulation of Hulle cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0070792 ! Hulle cell development + +[Term] +id: GO:0070809 +name: negative regulation of Hulle cell development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0070808 ! regulation of Hulle cell development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0070792 ! Hulle cell development + +[Term] +id: GO:0070810 +name: positive regulation of Hulle cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body." [GOC:mah] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0070808 ! regulation of Hulle cell development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0070792 ! Hulle cell development + +[Term] +id: GO:0070811 +name: glycerol-2-phosphate transmembrane transport +namespace: biological_process +def: "The process in which glycerol-2-phosphate is transported across a membrane. Glycerol-2-phosphate is a phosphoric monoester of glycerol." [GOC:mah] +synonym: "glycerol-2-phosphate transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015748 ! organophosphate ester transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:0070813 +name: hydrogen sulfide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [GOC:mah] +synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah] +synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah] +synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah] +is_a: GO:0006790 ! sulfur compound metabolic process + +[Term] +id: GO:0070814 +name: hydrogen sulfide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [GOC:mah] +synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah] +synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah] +synonym: "hydrogen sulfide formation" EXACT [GOC:mah] +synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah] +synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah] +synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah] +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0070813 ! hydrogen sulfide metabolic process + +[Term] +id: GO:0070815 +name: peptidyl-lysine 5-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2." [PMID:19574390] +synonym: "lysine hydroxylase activity" BROAD [GOC:mah] +synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [GOC:mah] +synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [GOC:mah] +synonym: "lysyl hydroxylase activity" BROAD [GOC:mah] +synonym: "peptide-lysine 5-dioxygenase activity" EXACT [GOC:mah] +synonym: "peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity" RELATED [EC:1.14.11.4, GOC:mah] +synonym: "peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity" RELATED [EC:1.14.11.4, GOC:mah] +synonym: "protein lysine hydroxylase activity" EXACT [GOC:mah] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0070816 +name: phosphorylation of RNA polymerase II C-terminal domain +namespace: biological_process +alt_id: GO:0016245 +def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] +synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah] +synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] +synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc] +synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0070817 +name: P-TEFb-cap methyltransferase complex localization +namespace: biological_process +def: "Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of P-TEFb-cap methyltransferase complex localization" EXACT [GOC:MAH] +synonym: "P-TEFb-cap methyltransferase complex localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0070818 +name: protoporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor." [EC:1.3.3.4, GOC:mah, PMID:19583219] +synonym: "protoporphyrinogen IX oxidase activity" RELATED [EC:1.3.3.4] +synonym: "protoporphyrinogen-IX oxidase activity" RELATED [EC:1.3.3.4] +synonym: "protoporphyrinogenase activity" RELATED [EC:1.3.3.4] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0070819 +name: menaquinone-dependent protoporphyrinogen oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone." [GOC:mah, PMID:19583219] +synonym: "protoporphyrinogen-IX:menaquinone oxidoreductase activity" EXACT [GOC:mah] +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor +is_a: GO:0070818 ! protoporphyrinogen oxidase activity + +[Term] +id: GO:0070820 +name: tertiary granule +namespace: cellular_component +def: "A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] +synonym: "gelatinase granule" EXACT [PMID:23650620] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0070821 +name: tertiary granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a tertiary granule." [GOC:BHF, GOC:mah, GOC:rl, PMID:12070036] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0070820 ! tertiary granule + +[Term] +id: GO:0070822 +name: Sin3-type complex +namespace: cellular_component +def: "Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex." [PMID:15565322, PMID:18292778] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000228 ! nuclear chromosome +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070823 +name: HDA1 complex +namespace: cellular_component +def: "A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p." [GOC:dgf, GOC:mah, PMID:11287668, PMID:8663039] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:0070824 +name: SHREC complex +namespace: cellular_component +def: "A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures." [GOC:mah, PMID:17289569] +synonym: "Snf2/HDAC containing repressor complex" EXACT [PMID:17289569, PMID:27105116] +synonym: "Snf2/Hdac repressive complex" EXACT [PMID:27105116] +is_a: GO:0000118 ! histone deacetylase complex + +[Term] +id: GO:0070825 +name: micropyle +namespace: cellular_component +def: "An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization." [GOC:cvs, GOC:mah, PMID:18649270] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042600 ! egg chorion + +[Term] +id: GO:0070826 +name: paraferritin complex +namespace: cellular_component +def: "A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme." [GOC:mah, GOC:rph, PMID:11842004, PMID:8639593] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070827 +name: obsolete chromatin maintenance +namespace: biological_process +def: "OBSOLETE. The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah] +comment: This term was obsoleted because it is redundant with chromatin organization and assembly terms. +is_obsolete: true + +[Term] +id: GO:0070828 +name: heterochromatin organization +namespace: biological_process +def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] +synonym: "heterochromatin organisation" EXACT [GOC:mah] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0070829 +name: obsolete heterochromatin maintenance +namespace: biological_process +alt_id: GO:0006344 +alt_id: GO:0070870 +def: "OBSOLETE. The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] +comment: This term was obsoleted because it is redundant with heterochromatin organization and assembly terms. +synonym: "heterochromatin maintenance involved in chromatin silencing" RELATED [] +synonym: "maintenance of chromatin silencing" RELATED [] +synonym: "maintenance of heterochromatic silencing" RELATED [] +is_obsolete: true + +[Term] +id: GO:0070830 +name: bicellular tight junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [GOC:mah] +synonym: "tight junction formation" EXACT [GOC:mah] +is_a: GO:0120192 ! tight junction assembly +relationship: part_of GO:0043297 ! apical junction assembly + +[Term] +id: GO:0070831 +name: basement membrane assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue." [GOC:mah] +comment: Note that this term has no relationship to 'membrane assembly ; GO:0071709' because the basement membrane is not a lipid bilayer. +is_a: GO:0071711 ! basement membrane organization +is_a: GO:0085029 ! extracellular matrix assembly + +[Term] +id: GO:0070832 +name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-2] +xref: MetaCyc:PWY4FS-2 +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0070833 +name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-3] +xref: MetaCyc:PWY4FS-3 +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process +is_a: GO:1901160 ! primary amino compound metabolic process + +[Term] +id: GO:0070834 +name: phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine." [MetaCyc:PWY4FS-4] +xref: MetaCyc:PWY4FS-4 +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0070835 +name: chromium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of chromium (Cr) ions from one side of a membrane to the other." [GOC:mah, GOC:yaf] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity + +[Term] +id: GO:0070836 +name: caveola assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane." [GOC:BHF, GOC:mah, GOC:vk, PMID:12633858] +synonym: "caveola formation" EXACT [GOC:mah] +synonym: "caveolar biogenesis" RELATED [PMID:12633858] +is_a: GO:0044854 ! plasma membrane raft assembly + +[Term] +id: GO:0070837 +name: dehydroascorbic acid transport +namespace: biological_process +def: "The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C." [GOC:sl] +synonym: "dehydroascorbate transport" EXACT [GOC:sl] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0070839 +name: metal ion export +namespace: biological_process +def: "The directed movement of metal cations, out of a cell or organelle." [GOC:mah] +synonym: "divalent metal ion export" NARROW [] +is_a: GO:0030001 ! metal ion transport + +[Term] +id: GO:0070840 +name: dynein complex binding +namespace: molecular_function +alt_id: GO:0045502 +def: "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity." [GOC:bf, GOC:BHF, GOC:mah] +synonym: "dynein binding" RELATED [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0070841 +name: inclusion body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:mah] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0070842 +name: aggresome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein." [GOC:BHF, GOC:rl, PMID:14675537] +is_a: GO:0070841 ! inclusion body assembly + +[Term] +id: GO:0070843 +name: misfolded protein transport +namespace: biological_process +def: "The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0070844 +name: polyubiquitinated protein transport +namespace: biological_process +def: "The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] +synonym: "polyubiquitylated protein transport" EXACT [GOC:mah] +is_a: GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0070845 +name: polyubiquitinated misfolded protein transport +namespace: biological_process +def: "The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell." [GOC:BHF, GOC:mah, PMID:14675537] +synonym: "misfolded polyubiquitinated protein transport" RELATED [GOC:mah] +synonym: "polyubiquitylated misfolded protein transport" EXACT [GOC:mah] +is_a: GO:0070843 ! misfolded protein transport +is_a: GO:0070844 ! polyubiquitinated protein transport + +[Term] +id: GO:0070846 +name: Hsp90 deacetylation +namespace: biological_process +def: "The modification of an Hsp90 protein by removal of acetyl groups." [GOC:BHF, GOC:mah] +is_a: GO:0006476 ! protein deacetylation + +[Term] +id: GO:0070847 +name: core mediator complex +namespace: cellular_component +def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] +synonym: "C mediator complex" EXACT [PMID:17870225] +synonym: "S mediator complex" EXACT [PMID:17043218] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0070848 +name: response to growth factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF, GOC:mah] +synonym: "response to growth factor stimulus" EXACT [GOC:dos] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0070849 +name: response to epidermal growth factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:BHF, GOC:mah] +synonym: "response to EGF stimulus" EXACT [GOC:mah] +synonym: "response to epidermal growth factor stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0070850 +name: TACC/TOG complex +namespace: cellular_component +def: "A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase." [GOC:mah, GOC:vw, PMID:19606211] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0070851 +name: growth factor receptor binding +namespace: molecular_function +def: "Binding to a growth factor receptor." [GOC:mah, GOC:vw] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0070852 +name: cell body fiber +namespace: cellular_component +def: "A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches." [GOC:dos, GOC:mah] +synonym: "cell body fibre" EXACT [] +synonym: "primary neurite" RELATED [GOC:dos, GOC:mah] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0070853 +name: myosin VI binding +namespace: molecular_function +def: "Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:15473855] +is_a: GO:0017022 ! myosin binding + +[Term] +id: GO:0070854 +name: myosin VI heavy chain binding +namespace: molecular_function +def: "Binding to a heavy chain of a myosin VI complex." [GOC:sart] +is_a: GO:0032036 ! myosin heavy chain binding +is_a: GO:0070853 ! myosin VI binding + +[Term] +id: GO:0070855 +name: myosin VI head/neck binding +namespace: molecular_function +def: "Binding to the head/neck region of a myosin VI heavy chain." [GOC:sart] +is_a: GO:0032028 ! myosin head/neck binding +is_a: GO:0070854 ! myosin VI heavy chain binding + +[Term] +id: GO:0070856 +name: myosin VI light chain binding +namespace: molecular_function +def: "Binding to a light chain of a myosin VI complex." [GOC:sart] +is_a: GO:0032027 ! myosin light chain binding +is_a: GO:0070853 ! myosin VI binding + +[Term] +id: GO:0070857 +name: regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "regulation of bile acid formation" EXACT [GOC:mah] +synonym: "regulation of bile acid synthesis" EXACT [GOC:mah] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +relationship: regulates GO:0006699 ! bile acid biosynthetic process + +[Term] +id: GO:0070858 +name: negative regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "down regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "downregulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "negative regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of bile acid formation" EXACT [GOC:mah] +synonym: "negative regulation of bile acid synthesis" EXACT [GOC:mah] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0070857 ! regulation of bile acid biosynthetic process +is_a: GO:1904252 ! negative regulation of bile acid metabolic process +relationship: negatively_regulates GO:0006699 ! bile acid biosynthetic process + +[Term] +id: GO:0070859 +name: positive regulation of bile acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids." [GOC:BHF, GOC:mah] +synonym: "activation of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "positive regulation of bile acid anabolism" EXACT [GOC:mah] +synonym: "positive regulation of bile acid biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of bile acid formation" EXACT [GOC:mah] +synonym: "positive regulation of bile acid synthesis" EXACT [GOC:mah] +synonym: "stimulation of bile acid biosynthetic process" NARROW [GOC:mah] +synonym: "up regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "up-regulation of bile acid biosynthetic process" EXACT [GOC:mah] +synonym: "upregulation of bile acid biosynthetic process" EXACT [GOC:mah] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0070857 ! regulation of bile acid biosynthetic process +is_a: GO:1904253 ! positive regulation of bile acid metabolic process +relationship: positively_regulates GO:0006699 ! bile acid biosynthetic process + +[Term] +id: GO:0070860 +name: RNA polymerase I core factor complex +namespace: cellular_component +def: "A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p." [PMID:8702872] +comment: Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does. +is_a: GO:0000120 ! RNA polymerase I transcription regulator complex + +[Term] +id: GO:0070861 +name: regulation of protein exit from endoplasmic reticulum +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] +synonym: "regulation of protein exit from ER" EXACT [GOC:mah] +synonym: "regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "regulation of protein export from ER" EXACT [GOC:mah] +is_a: GO:0033157 ! regulation of intracellular protein transport +relationship: regulates GO:0032527 ! protein exit from endoplasmic reticulum + +[Term] +id: GO:0070862 +name: negative regulation of protein exit from endoplasmic reticulum +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the endoplasmic reticulum." [GOC:mah] +synonym: "down regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "down-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "downregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "inhibition of protein exit from endoplasmic reticulum" NARROW [GOC:mah] +synonym: "negative regulation of protein exit from ER" EXACT [GOC:mah] +synonym: "negative regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "negative regulation of protein export from ER" EXACT [GOC:mah] +is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum +is_a: GO:0090317 ! negative regulation of intracellular protein transport +relationship: negatively_regulates GO:0032527 ! protein exit from endoplasmic reticulum + +[Term] +id: GO:0070863 +name: positive regulation of protein exit from endoplasmic reticulum +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the endoplasmic reticulum." [GOC:mah] +synonym: "activation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] +synonym: "positive regulation of protein exit from ER" EXACT [GOC:mah] +synonym: "positive regulation of protein export from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "positive regulation of protein export from ER" EXACT [GOC:mah] +synonym: "stimulation of protein exit from endoplasmic reticulum" NARROW [GOC:mah] +synonym: "up regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "up-regulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +synonym: "upregulation of protein exit from endoplasmic reticulum" EXACT [GOC:mah] +is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum +is_a: GO:0090316 ! positive regulation of intracellular protein transport +relationship: positively_regulates GO:0032527 ! protein exit from endoplasmic reticulum + +[Term] +id: GO:0070864 +name: sperm individualization complex +namespace: cellular_component +def: "A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst." [GOC:sart, PMID:10588662, PMID:9550716] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0070865 +name: investment cone +namespace: cellular_component +def: "A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization." [GOC:sart, PMID:15829565, PMID:9550716] +synonym: "F-actin cone" EXACT [PMID:15829565] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0070864 ! sperm individualization complex + +[Term] +id: GO:0070866 +name: sterol-dependent protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex in the presence of sterols." [GOC:ecd] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0070867 +name: mating projection tip membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a mating projection tip." [GOC:mah] +synonym: "mating projection membrane fusion domain" EXACT [PMID:29134248] +synonym: "shmoo tip membrane" NARROW [GOC:mah] +is_a: GO:0031520 ! plasma membrane of cell tip +relationship: part_of GO:0043332 ! mating projection tip + +[Term] +id: GO:0070868 +name: obsolete heterochromatin organization involved in chromatin silencing +namespace: biological_process +def: "OBSOLETE. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] +comment: This term was obsoleted because it was not clearly defined, and used incorrectly. +synonym: "heterochromatin organisation involved in chromatin silencing" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0070871 +name: cell wall organization involved in conjugation with cellular fusion +namespace: biological_process +def: "A process of cell wall organization that contributes to conjugation with cellular fusion." [GOC:mah] +synonym: "cell wall organisation involved in conjugation with cellular fusion" EXACT [GOC:mah] +is_a: GO:0022414 ! reproductive process +is_a: GO:0071555 ! cell wall organization +relationship: part_of GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0070873 +name: regulation of glycogen metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] +synonym: "regulation of glycogen metabolism" EXACT [GOC:mah] +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0005977 ! glycogen metabolic process + +[Term] +id: GO:0070874 +name: negative regulation of glycogen metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] +synonym: "negative regulation of glycogen metabolism" EXACT [GOC:mah] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +relationship: negatively_regulates GO:0005977 ! glycogen metabolic process + +[Term] +id: GO:0070875 +name: positive regulation of glycogen metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen." [GOC:mah] +synonym: "positive regulation of glycogen metabolism" EXACT [GOC:mah] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010907 ! positive regulation of glucose metabolic process +is_a: GO:0070873 ! regulation of glycogen metabolic process +relationship: positively_regulates GO:0005977 ! glycogen metabolic process + +[Term] +id: GO:0070876 +name: SOSS complex +namespace: cellular_component +def: "A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80." [PMID:19683501] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0070877 +name: microprocessor complex +namespace: cellular_component +def: "A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs." [PMID:16963499, PMID:17159994] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1903095 ! ribonuclease III complex + +[Term] +id: GO:0070878 +name: primary miRNA binding +namespace: molecular_function +def: "Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding." [GOC:sl, PMID:15531877, PMID:15574589] +synonym: "pri-miRNA binding" EXACT [] +synonym: "primary microRNA binding" EXACT [PMID:15531877, PMID:15574589] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0070879 +name: fungal-type cell wall beta-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah, GOC:vw] +synonym: "fungal-type cell wall beta-glucan metabolism" EXACT [GOC:mah] +is_a: GO:0034406 ! cell wall beta-glucan metabolic process +is_a: GO:0071966 ! fungal-type cell wall polysaccharide metabolic process +relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0070880 +name: fungal-type cell wall beta-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:mah] +synonym: "fungal-type cell wall beta-glucan anabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-glucan biosynthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-glucan formation" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0034410 ! cell wall beta-glucan biosynthetic process +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process +is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process + +[Term] +id: GO:0070881 +name: regulation of proline transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proline transport." [GOC:mah] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0015824 ! proline transport + +[Term] +id: GO:0070883 +name: pre-miRNA binding +namespace: molecular_function +def: "Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA." [PMID:18951094] +synonym: "pre-microRNA binding" EXACT [GOC:pr] +synonym: "precursor microRNA binding" EXACT [PMID:18951094] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0070884 +name: regulation of calcineurin-NFAT signaling cascade +namespace: biological_process +alt_id: GO:0051531 +alt_id: GO:0051532 +def: "Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:ai] +synonym: "NFAT protein import into nucleus" NARROW [] +synonym: "regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] +synonym: "regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] +synonym: "regulation of NFAT protein import into nucleus" NARROW [] +is_a: GO:0106056 ! regulation of calcineurin-mediated signaling +relationship: regulates GO:0033173 ! calcineurin-NFAT signaling cascade + +[Term] +id: GO:0070885 +name: negative regulation of calcineurin-NFAT signaling cascade +namespace: biological_process +alt_id: GO:0051534 +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade." [GOC:mah] +synonym: "down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +synonym: "down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +synonym: "downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +synonym: "inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] +synonym: "inhibition of NFAT protein import into nucleus" NARROW [] +synonym: "negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] +synonym: "negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] +synonym: "negative regulation of NFAT protein import into nucleus" NARROW [] +synonym: "termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf] +is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade +is_a: GO:0106057 ! negative regulation of calcineurin-mediated signaling +relationship: negatively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade + +[Term] +id: GO:0070886 +name: positive regulation of calcineurin-NFAT signaling cascade +namespace: biological_process +alt_id: GO:0051533 +def: "Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade." [GOC:mah] +synonym: "activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] +synonym: "positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] +synonym: "positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] +synonym: "positive regulation of NFAT protein import into nucleus" NARROW [] +synonym: "stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] +synonym: "up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +synonym: "up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +synonym: "upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] +is_a: GO:0070884 ! regulation of calcineurin-NFAT signaling cascade +is_a: GO:0106058 ! positive regulation of calcineurin-mediated signaling +relationship: positively_regulates GO:0033173 ! calcineurin-NFAT signaling cascade + +[Term] +id: GO:0070887 +name: cellular response to chemical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0042221 ! response to chemical +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0070888 +name: E-box binding +namespace: molecular_function +def: "Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues." [GOC:BHF, GOC:vk, PMID:11812799] +synonym: "E-box promoter binding" EXACT [GOC:vk] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0070889 +name: platelet alpha granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets." [GOC:rph, PMID:16123220] +synonym: "platelet alpha granule organisation" EXACT [GOC:mah] +synonym: "platelet alpha granule organization and biogenesis" RELATED [GOC:mah] +synonym: "platelet alpha-granule organization" EXACT [GOC:mah] +is_a: GO:0033363 ! secretory granule organization + +[Term] +id: GO:0070891 +name: lipoteichoic acid binding +namespace: molecular_function +def: "Binding to lipoteichoic acid." [GOC:add, PMID:14665680] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0070892 +name: lipoteichoic acid immune receptor activity +namespace: molecular_function +def: "Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response." [GOC:add, PMID:14665680] +synonym: "lipoteichoic acid receptor activity" BROAD [] +is_a: GO:0038187 ! pattern recognition receptor activity + +[Term] +id: GO:0070893 +name: transposon integration +namespace: biological_process +def: "Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome." [GOC:jp, PMID:10882723] +is_a: GO:0015074 ! DNA integration +is_a: GO:0032196 ! transposition + +[Term] +id: GO:0070894 +name: regulation of transposon integration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of regulation of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] +is_a: GO:0010528 ! regulation of transposition +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0070893 ! transposon integration + +[Term] +id: GO:0070895 +name: negative regulation of transposon integration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] +synonym: "down regulation of transposon integration" EXACT [GOC:mah] +synonym: "down-regulation of transposon integration" EXACT [GOC:mah] +synonym: "downregulation of transposon integration" EXACT [GOC:mah] +synonym: "inhibition of transposon integration" NARROW [GOC:mah] +is_a: GO:0010529 ! negative regulation of transposition +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0070894 ! regulation of transposon integration +relationship: negatively_regulates GO:0070893 ! transposon integration + +[Term] +id: GO:0070896 +name: positive regulation of transposon integration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transposon integration, a process in which a transposable element is incorporated into another DNA molecule." [GOC:mah] +synonym: "activation of transposon integration" NARROW [GOC:mah] +synonym: "stimulation of transposon integration" NARROW [GOC:mah] +synonym: "up regulation of transposon integration" EXACT [GOC:mah] +synonym: "up-regulation of transposon integration" EXACT [GOC:mah] +synonym: "upregulation of transposon integration" EXACT [GOC:mah] +is_a: GO:0010530 ! positive regulation of transposition +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0070894 ! regulation of transposon integration +relationship: positively_regulates GO:0070893 ! transposon integration + +[Term] +id: GO:0070897 +name: transcription preinitiation complex assembly +namespace: biological_process +alt_id: GO:0001126 +def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription." [GOC:jp, GOC:txnOH] +synonym: "bacterial-type RNA polymerase preinitiation complex assembly" NARROW [] +synonym: "bacterial-type RNA polymerase transcription PIC formation" NARROW [] +synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" NARROW [] +synonym: "DNA-dependent transcriptional preinitiation complex assembly" EXACT [GOC:txnOH] +synonym: "DNA-templated transcriptional preinitiation complex assembly" EXACT [] +synonym: "transcription PIC biosynthesis" BROAD [GOC:mah] +synonym: "transcription PIC formation" BROAD [GOC:mah] +synonym: "transcriptional preinitiation complex formation" BROAD [GOC:mah] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:0070898 +name: RNA polymerase III preinitiation complex assembly +namespace: biological_process +alt_id: GO:0000999 +alt_id: GO:0001020 +alt_id: GO:0001021 +alt_id: GO:0001043 +def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter." [GOC:jp, GOC:txnOH, PMID:11387215, PMID:12381659] +synonym: "RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly" NARROW [] +synonym: "RNA polymerase III transcription PIC biosynthesis" EXACT [GOC:mah] +synonym: "RNA polymerase III transcription PIC formation" EXACT [GOC:mah] +synonym: "RNA polymerase III transcriptional preinitiation complex assembly" EXACT [] +synonym: "RNA polymerase III transcriptional preinitiation complex formation" EXACT [GOC:mah] +synonym: "RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly" NARROW [] +synonym: "RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly" NARROW [] +synonym: "RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly" NARROW [] +is_a: GO:0070897 ! transcription preinitiation complex assembly +relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter + +[Term] +id: GO:0070899 +name: mitochondrial tRNA wobble uridine modification +namespace: biological_process +def: "The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified." [GOC:mah, GOC:mcc] +is_a: GO:0002098 ! tRNA wobble uridine modification +is_a: GO:0070900 ! mitochondrial tRNA modification + +[Term] +id: GO:0070900 +name: mitochondrial tRNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically." [GOC:mah, GOC:mcc] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process +is_a: GO:0090646 ! mitochondrial tRNA processing +is_a: GO:1900864 ! mitochondrial RNA modification + +[Term] +id: GO:0070901 +name: mitochondrial tRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] +is_a: GO:0030488 ! tRNA methylation +is_a: GO:0070900 ! mitochondrial tRNA modification + +[Term] +id: GO:0070902 +name: mitochondrial tRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] +is_a: GO:0031119 ! tRNA pseudouridine synthesis +is_a: GO:0070900 ! mitochondrial tRNA modification + +[Term] +id: GO:0070903 +name: mitochondrial tRNA thio-modification +namespace: biological_process +def: "The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule." [GOC:mah, GOC:mcc] +is_a: GO:0034227 ! tRNA thio-modification +is_a: GO:0070900 ! mitochondrial tRNA modification + +[Term] +id: GO:0070904 +name: transepithelial L-ascorbic acid transport +namespace: biological_process +def: "The directed movement of L-ascorbic acid from one side of an epithelium to the other." [GOC:mah, GOC:yaf] +synonym: "transepithelial L-ascorbate transport" EXACT [GOC:mah] +synonym: "transepithelial vitamin C transport" EXACT [GOC:mah] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0070633 ! transepithelial transport + +[Term] +id: GO:0070905 +name: serine binding +namespace: molecular_function +def: "Binding to 2-amino-3-hydroxypropanoic acid." [GOC:rph] +synonym: "Ser binding" EXACT [GOC:mah] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:0070906 +name: aspartate:alanine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: aspartate(out) + alanine(in) = aspartate(in) + alanine(out)." [GOC:dh] +synonym: "aspartate-alanine antiporter activity" EXACT [GOC:mah] +synonym: "aspartate/alanine antiporter activity" EXACT [GOC:mah] +xref: RHEA:33139 +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity +is_a: GO:0022858 ! alanine transmembrane transporter activity + +[Term] +id: GO:0070907 +name: histidine:histamine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: histidine(out) + histamine(in) = histidine(in) + histamine(out)." [GOC:dh] +synonym: "histidine-histamine antiporter activity" EXACT [GOC:mah] +synonym: "histidine/histamine antiporter activity" EXACT [GOC:mah] +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:0070908 +name: tyrosine:tyramine antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: tyrosine(out) + tyramine(in) = tyrosine(in) + tyramine(out)." [GOC:dh] +synonym: "tyrosine-tyramine antiporter activity" EXACT [GOC:mah] +synonym: "tyrosine/tyramine antiporter activity" EXACT [GOC:mah] +is_a: GO:0008504 ! monoamine transmembrane transporter activity +is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity +is_a: GO:0015298 ! solute:cation antiporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:0070909 +name: glutamate:gamma-aminobutyric acid antiporter activity +namespace: molecular_function +def: "Catalysis of the reaction: glutamate(out) + gamma-aminobutyric acid(in) = glutamate(in) + gamma-aminobutyric acid(out)." [GOC:dh] +synonym: "glutamate-gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] +synonym: "glutamate/gamma-aminobutyric acid antiporter activity" EXACT [GOC:mah] +synonym: "glutamate: GABA antiporter activity" EXACT [GOC:dh] +is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity +is_a: GO:0015301 ! anion:anion antiporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0070910 +name: cell wall macromolecule catabolic process involved in cell wall disassembly +namespace: biological_process +def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the cell wall." [GOC:mah] +is_a: GO:0016998 ! cell wall macromolecule catabolic process +relationship: part_of GO:0044277 ! cell wall disassembly + +[Term] +id: GO:0070911 +name: global genome nucleotide-excision repair +namespace: biological_process +def: "The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." [PMID:10197977, PMID:18794354] +synonym: "GG-NER" EXACT [PMID:10197977] +synonym: "GGR" EXACT [GOC:vw, PMID:18794354] +synonym: "global genome NER" EXACT [GOC:mah] +synonym: "global genomic nucleotide-excision repair" EXACT [GOC:mah, GOC:vw] +synonym: "global genomic repair" EXACT [GOC:vw, PMID:18794354] +is_a: GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:0070912 +name: Ddb1-Ckn1 complex +namespace: cellular_component +def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0070913 +name: Ddb1-Wdr21 complex +namespace: cellular_component +def: "A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases." [PMID:18794354] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0070914 +name: UV-damage excision repair +namespace: biological_process +def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100] +synonym: "AER" RELATED [GOC:mah, PMID:10704216] +synonym: "alternative excision repair" RELATED [GOC:mah, PMID:10704216] +synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw] +synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100] +synonym: "UVER" EXACT [GOC:vw, PMID:9619100] +is_a: GO:0006281 ! DNA repair +is_a: GO:0034644 ! cellular response to UV + +[Term] +id: GO:0070915 +name: lysophosphatidic acid receptor activity +namespace: molecular_function +def: "Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:15755723] +synonym: "LPA receptor activity" EXACT [PMID:15755723] +is_a: GO:0045125 ! bioactive lipid receptor activity + +[Term] +id: GO:0070916 +name: inositol phosphoceramide synthase complex +namespace: cellular_component +def: "A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces)." [GOC:mah, PMID:19726565] +synonym: "IPC synthase complex" EXACT [GOC:mah] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0070917 +name: inositol phosphoceramide synthase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of inositol phosphoceramide synthase." [GOC:mah] +comment: See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. +synonym: "IPC synthase regulator activity" EXACT [] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0070918 +name: primary sncRNA processing +namespace: biological_process +def: "Any process involved in the conversion of a primary sncRNA (short non-coding RNA) transcript into a mature sncRNA molecule." [GOC:mah, PMID:19239886] +synonym: "gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] +synonym: "gene silencing by RNA, production of small RNA" EXACT [GOC:mah] +synonym: "production of small RNA involved in gene silencing by RNA" RELATED [] +synonym: "sncRNA processing" RELATED [] +is_a: GO:0034470 ! ncRNA processing +relationship: part_of GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0070919 +name: production of siRNA involved in gene silencing by small RNA +namespace: biological_process +def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA." [GOC:mah, PMID:19239886] +synonym: "chromatin silencing by small RNA, production of guide RNAs" EXACT [] +synonym: "chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] +synonym: "production of guide RNAs involved in chromatin silencing by small RNA" EXACT [GOC:mah] +synonym: "production of siRNA involved in chromatin silencing by small RNA" EXACT [] +is_a: GO:0070918 ! primary sncRNA processing +relationship: part_of GO:0031048 ! heterochromatin assembly by small RNA + +[Term] +id: GO:0070920 +name: regulation of production of small RNA involved in gene silencing by RNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA." [GOC:mah] +synonym: "regulation of gene silencing by RNA, production of guide RNA" EXACT [GOC:mah] +synonym: "regulation of gene silencing by RNA, production of small RNA" EXACT [GOC:mah] +is_a: GO:0051252 ! regulation of RNA metabolic process +is_a: GO:0060966 ! regulation of gene silencing by RNA +relationship: regulates GO:0070918 ! primary sncRNA processing + +[Term] +id: GO:0070921 +name: regulation of production of siRNA involved in gene silencing by small RNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA." [GOC:mah] +synonym: "regulation of chromatin silencing by small RNA, production of siRNA" EXACT [GOC:mah] +synonym: "regulation of production of siRNA involved in chromatin silencing by small RNA" EXACT [] +is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA + +[Term] +id: GO:0070922 +name: small RNA loading onto RISC +namespace: biological_process +def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA." [GOC:mah, PMID:19239886] +comment: This term should not be used for direct annotation. Annotations should be made to one of the more specific children. +subset: gocheck_do_not_annotate +synonym: "gene silencing by RNA, small RNA loading onto RISC" EXACT [GOC:mah] +synonym: "RISC assembly" RELATED [GOC:mah] +is_a: GO:0022618 ! ribonucleoprotein complex assembly +relationship: part_of GO:0031047 ! gene silencing by RNA + +[Term] +id: GO:0070923 +name: siRNA loading onto RISC involved in gene silencing by small RNA +namespace: biological_process +def: "The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of heterochromatin assembly, leading to gene silencing." [GOC:mah, PMID:19239886] +synonym: "chromatin silencing by small RNA, siRNA loading onto RISC" EXACT [GOC:mah] +synonym: "siRNA loading onto RISC involved in chromatin silencing by small RNA" EXACT [] +is_a: GO:0070922 ! small RNA loading onto RISC +relationship: part_of GO:0031048 ! heterochromatin assembly by small RNA + +[Term] +id: GO:0070925 +name: organelle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] +subset: goslim_yeast +is_a: GO:0006996 ! organelle organization +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0070926 +name: regulation of ATP:ADP antiporter activity +namespace: biological_process +def: "Any process that modulates the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] +is_a: GO:0032239 ! regulation of nucleobase-containing compound transport +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1903959 ! regulation of anion transmembrane transport + +[Term] +id: GO:0070927 +name: negative regulation of ATP:ADP antiporter activity +namespace: biological_process +def: "Any process that stops or reduces the activity of an ATP:ADP antiporter." [GOC:BHF, GOC:mah] +synonym: "down regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] +synonym: "down-regulation of ATP:ADP antiporter activity" EXACT [GOC:mah] +synonym: "downregulation of ATP:ADP antiporter activity" EXACT [GOC:mah] +synonym: "inhibition of ATP:ADP antiporter activity" NARROW [GOC:mah] +is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0070926 ! regulation of ATP:ADP antiporter activity +is_a: GO:1903960 ! negative regulation of anion transmembrane transport + +[Term] +id: GO:0070928 +name: regulation of mRNA stability, ncRNA-mediated +namespace: biological_process +def: "Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jh2] +synonym: "ncRNA-mediated regulation of mRNA stability" EXACT [GOC:mah] +synonym: "regulation of mRNA stability, non-coding RNA-mediated" EXACT [GOC:mah] +is_a: GO:0043488 ! regulation of mRNA stability + +[Term] +id: GO:0070929 +name: trans-translation +namespace: biological_process +def: "A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes." [GOC:jh2, GOC:mah] +is_a: GO:0006414 ! translational elongation + +[Term] +id: GO:0070930 +name: trans-translation-dependent protein tagging +namespace: biological_process +def: "A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation." [GOC:jh2, GOC:jsg, GOC:mah] +comment: Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus. +synonym: "co-translational protein tagging" EXACT [GOC:jh2, GOC:jsg] +synonym: "cotranslational protein tagging" EXACT [GOC:mah] +synonym: "protein modification by trans-translation" EXACT [GOC:mah] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0070931 +name: Golgi-associated vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a Golgi-associated vesicle." [GOC:mah] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0005794 ! Golgi apparatus +relationship: part_of GO:0005798 ! Golgi-associated vesicle + +[Term] +id: GO:0070932 +name: histone H3 deacetylation +namespace: biological_process +def: "The modification of histone H3 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] +is_a: GO:0016575 ! histone deacetylation + +[Term] +id: GO:0070933 +name: histone H4 deacetylation +namespace: biological_process +def: "The modification of histone H4 by the removal of one or more acetyl groups." [GOC:BHF, GOC:rl] +is_a: GO:0016575 ! histone deacetylation + +[Term] +id: GO:0070934 +name: CRD-mediated mRNA stabilization +namespace: biological_process +def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD)." [GOC:mah, PMID:19029303] +synonym: "coding region determinant-mediated mRNA stabilization" EXACT [GOC:mah] +is_a: GO:0048255 ! mRNA stabilization + +[Term] +id: GO:0070935 +name: 3'-UTR-mediated mRNA stabilization +namespace: biological_process +def: "An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA." [GOC:mah, PMID:19029303] +synonym: "3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:mah] +is_a: GO:0048255 ! mRNA stabilization + +[Term] +id: GO:0070936 +name: protein K48-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." [GOC:cvs, PMID:15556404] +synonym: "protein K48-linked polyubiquitination" EXACT [GOC:mah] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0070937 +name: CRD-mediated mRNA stability complex +namespace: cellular_component +def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9." [GOC:mah, PMID:19029303] +comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. +synonym: "coding-region determinant of instability-mediated mRNA stability complex" EXACT [] +synonym: "coding-region instability determinant -mediated mRNA stability complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070938 +name: contractile ring +namespace: cellular_component +def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] +synonym: "constriction ring" RELATED [GOC:mah] +synonym: "cytokinetic ring" RELATED [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0070939 +name: Dsl1/NZR complex +namespace: cellular_component +def: "A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p." [GOC:jh, GOC:mah, PMID:19151722, PMID:21550981] +comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. +synonym: "CATCHR family complex" BROAD [] +synonym: "Dsl1p complex" EXACT [PMID:19151722] +synonym: "NZR complex" EXACT [PMID:25364732] +is_a: GO:0099023 ! vesicle tethering complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex + +[Term] +id: GO:0070940 +name: dephosphorylation of RNA polymerase II C-terminal domain +namespace: biological_process +def: "The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form." [GOC:krc, GOC:mah, PMID:17079683] +synonym: "CTD domain dephosphorylation of RNA polymerase II" EXACT [GOC:mah] +synonym: "generation of hypophosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] +synonym: "generation of II(A) form of RNA polymerase II" EXACT [GOC:krc] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0070941 +name: eisosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane." [GOC:al, GOC:jp, GOC:mah, PMID:19564405] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0070942 +name: neutrophil mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a neutrophil." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated cell killing" EXACT [GOC:add] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002446 ! neutrophil mediated immunity + +[Term] +id: GO:0070943 +name: neutrophil-mediated killing of symbiont cell +namespace: biological_process +def: "The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated killing of symbiont cell" EXACT [] +is_a: GO:0051873 ! killing by host of symbiont cells +is_a: GO:0070942 ! neutrophil mediated cytotoxicity + +[Term] +id: GO:0070944 +name: neutrophil-mediated killing of bacterium +namespace: biological_process +def: "The directed killing of a bacterium by a neutrophil." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated killing of bacterium" EXACT [] +is_a: GO:0070943 ! neutrophil-mediated killing of symbiont cell +relationship: part_of GO:0042742 ! defense response to bacterium + +[Term] +id: GO:0070945 +name: neutrophil-mediated killing of gram-negative bacterium +namespace: biological_process +def: "The directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated killing of gram-negative bacterium" EXACT [] +is_a: GO:0070944 ! neutrophil-mediated killing of bacterium +relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium + +[Term] +id: GO:0070946 +name: neutrophil-mediated killing of gram-positive bacterium +namespace: biological_process +def: "The directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated killing of gram-positive bacterium" EXACT [] +is_a: GO:0070944 ! neutrophil-mediated killing of bacterium +relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium + +[Term] +id: GO:0070947 +name: neutrophil-mediated killing of fungus +namespace: biological_process +def: "The directed killing of a fungal cell by a neutrophil." [GOC:add, ISBN:0781765196] +synonym: "neutrophil mediated killing of fungus" EXACT [] +is_a: GO:0070943 ! neutrophil-mediated killing of symbiont cell +relationship: part_of GO:0050832 ! defense response to fungus + +[Term] +id: GO:0070948 +name: regulation of neutrophil mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "regulation of neutrophil mediated cell killing" EXACT [GOC:add] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: regulates GO:0070942 ! neutrophil mediated cytotoxicity + +[Term] +id: GO:0070949 +name: regulation of neutrophil mediated killing of symbiont cell +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity +relationship: regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell + +[Term] +id: GO:0070950 +name: regulation of neutrophil mediated killing of bacterium +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] +is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell +relationship: regulates GO:0070944 ! neutrophil-mediated killing of bacterium + +[Term] +id: GO:0070951 +name: regulation of neutrophil mediated killing of gram-negative bacterium +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-negative bacterium, the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] +is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium +relationship: regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium + +[Term] +id: GO:0070952 +name: regulation of neutrophil mediated killing of gram-positive bacterium +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a gram-positive bacterium, the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] +is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium +relationship: regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium + +[Term] +id: GO:0070953 +name: regulation of neutrophil mediated killing of fungus +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] +is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell +is_a: GO:1900150 ! regulation of defense response to fungus +relationship: regulates GO:0070947 ! neutrophil-mediated killing of fungus + +[Term] +id: GO:0070954 +name: negative regulation of neutrophil mediated cytotoxicity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated cytotoxicity" NARROW [GOC:mah] +synonym: "negative regulation of neutrophil mediated cell killing" EXACT [GOC:add] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity +relationship: negatively_regulates GO:0070942 ! neutrophil mediated cytotoxicity + +[Term] +id: GO:0070955 +name: negative regulation of neutrophil mediated killing of symbiont cell +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell +is_a: GO:0070954 ! negative regulation of neutrophil mediated cytotoxicity +relationship: negatively_regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell + +[Term] +id: GO:0070956 +name: negative regulation of neutrophil mediated killing of bacterium +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated killing of bacterium" NARROW [GOC:mah] +is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium +is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell +relationship: negatively_regulates GO:0070944 ! neutrophil-mediated killing of bacterium + +[Term] +id: GO:0070957 +name: negative regulation of neutrophil mediated killing of gram-negative bacterium +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] +is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium +is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium +relationship: negatively_regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium + +[Term] +id: GO:0070958 +name: negative regulation of neutrophil mediated killing of gram-positive bacterium +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] +is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium +is_a: GO:0070956 ! negative regulation of neutrophil mediated killing of bacterium +relationship: negatively_regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium + +[Term] +id: GO:0070959 +name: negative regulation of neutrophil mediated killing of fungus +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "down regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +synonym: "down-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +synonym: "downregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +synonym: "inhibition of neutrophil mediated killing of fungus" NARROW [GOC:mah] +is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus +is_a: GO:0070955 ! negative regulation of neutrophil mediated killing of symbiont cell +relationship: negatively_regulates GO:0070947 ! neutrophil-mediated killing of fungus + +[Term] +id: GO:0070960 +name: positive regulation of neutrophil mediated cytotoxicity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] +synonym: "positive regulation of neutrophil mediated cell killing" EXACT [GOC:add] +synonym: "stimulation of neutrophil mediated cytotoxicity" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated cytotoxicity" EXACT [GOC:mah] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0070948 ! regulation of neutrophil mediated cytotoxicity +relationship: positively_regulates GO:0070942 ! neutrophil mediated cytotoxicity + +[Term] +id: GO:0070961 +name: positive regulation of neutrophil mediated killing of symbiont cell +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] +synonym: "stimulation of neutrophil mediated killing of symbiont cell" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated killing of symbiont cell" EXACT [GOC:mah] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0070949 ! regulation of neutrophil mediated killing of symbiont cell +is_a: GO:0070960 ! positive regulation of neutrophil mediated cytotoxicity +relationship: positively_regulates GO:0070943 ! neutrophil-mediated killing of symbiont cell + +[Term] +id: GO:0070962 +name: positive regulation of neutrophil mediated killing of bacterium +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] +synonym: "stimulation of neutrophil mediated killing of bacterium" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated killing of bacterium" EXACT [GOC:mah] +is_a: GO:0070950 ! regulation of neutrophil mediated killing of bacterium +is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell +is_a: GO:1900426 ! positive regulation of defense response to bacterium +relationship: positively_regulates GO:0070944 ! neutrophil-mediated killing of bacterium + +[Term] +id: GO:0070963 +name: positive regulation of neutrophil mediated killing of gram-negative bacterium +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-negative bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] +synonym: "stimulation of neutrophil mediated killing of gram-negative bacterium" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated killing of gram-negative bacterium" EXACT [GOC:mah] +is_a: GO:0070951 ! regulation of neutrophil mediated killing of gram-negative bacterium +is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium +relationship: positively_regulates GO:0070945 ! neutrophil-mediated killing of gram-negative bacterium + +[Term] +id: GO:0070964 +name: positive regulation of neutrophil mediated killing of gram-positive bacterium +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] +synonym: "stimulation of neutrophil mediated killing of gram-positive bacterium" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated killing of gram-positive bacterium" EXACT [GOC:mah] +is_a: GO:0070952 ! regulation of neutrophil mediated killing of gram-positive bacterium +is_a: GO:0070962 ! positive regulation of neutrophil mediated killing of bacterium +relationship: positively_regulates GO:0070946 ! neutrophil-mediated killing of gram-positive bacterium + +[Term] +id: GO:0070965 +name: positive regulation of neutrophil mediated killing of fungus +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the directed killing of a fungal cell by a neutrophil." [GOC:add, GOC:mah] +synonym: "activation of neutrophil mediated killing of fungus" NARROW [GOC:mah] +synonym: "stimulation of neutrophil mediated killing of fungus" NARROW [GOC:mah] +synonym: "up regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +synonym: "up-regulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +synonym: "upregulation of neutrophil mediated killing of fungus" EXACT [GOC:mah] +is_a: GO:0070953 ! regulation of neutrophil mediated killing of fungus +is_a: GO:0070961 ! positive regulation of neutrophil mediated killing of symbiont cell +relationship: positively_regulates GO:0070947 ! neutrophil-mediated killing of fungus + +[Term] +id: GO:0070966 +name: nuclear-transcribed mRNA catabolic process, no-go decay +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation." [GOC:jp, PMID:16554824] +synonym: "no-go decay" EXACT [GOC:jp] +synonym: "no-go mRNA decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA breakdown, no-go decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA catabolism, no-go decay" EXACT [GOC:jp] +synonym: "nuclear-transcribed mRNA degradation, no-go decay" EXACT [GOC:jp] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process + +[Term] +id: GO:0070967 +name: coenzyme F420 binding +namespace: molecular_function +def: "Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:dh] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:0097367 ! carbohydrate derivative binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0070968 +name: pyrroloquinoline quinone binding +namespace: molecular_function +def: "Binding to pyrroloquinoline quinone, PQQ, the coenzyme or the prosthetic group of certain alcohol dehydrogenases and glucose dehydrogenases." [GOC:dh] +synonym: "PQQ binding" EXACT [GOC:dh] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0048038 ! quinone binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0070971 +name: endoplasmic reticulum exit site +namespace: cellular_component +def: "An endoplasmic reticulum part at which COPII-coated vesicles are produced." [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052] +synonym: "ER exit site" EXACT [GOC:mah] +synonym: "transitional ER" EXACT [PMID:15623529] +xref: NIF_Subcellular:sao124393998 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0070972 +name: protein localization to endoplasmic reticulum +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah] +synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah] +synonym: "protein localization in endoplasmic reticulum" EXACT [] +synonym: "protein localization in ER" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0070973 +name: protein localization to endoplasmic reticulum exit site +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site." [GOC:mah] +synonym: "protein localisation to endoplasmic reticulum exit site" EXACT [GOC:mah] +synonym: "protein localization to ER exit site" EXACT [GOC:mah] +is_a: GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:0070974 +name: POU domain binding +namespace: molecular_function +def: "Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors." [GOC:mah, GOC:yaf, InterPro:IPR000327] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070975 +name: FHA domain binding +namespace: molecular_function +def: "Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich." [GOC:mah, InterPro:IPR000253] +synonym: "Forkhead-associated domain binding" EXACT [InterPro:IPR000253] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070976 +name: TIR domain binding +namespace: molecular_function +def: "Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] +subset: goslim_chembl +synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070977 +name: bone maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state." [GOC:dph, GOC:mah] +is_a: GO:0048799 ! animal organ maturation +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0070978 +name: voltage-gated calcium channel complex assembly +namespace: biological_process +def: "Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex." [GOC:mh] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0070979 +name: protein K11-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains." [GOC:jsg, GOC:pr, GOC:sp, PMID:18485873, PMID:20655260, PMID:21113135] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0070980 +name: biphenyl catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [PMID:16310831, PMID:16339959, UniPathway:UPA00155] +synonym: "biphenyl breakdown" EXACT [GOC:mah] +synonym: "biphenyl catabolism" EXACT [GOC:mah] +synonym: "biphenyl degradation" EXACT [GOC:mah] +is_a: GO:0018879 ! biphenyl metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042178 ! xenobiotic catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0070981 +name: L-asparagine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah] +synonym: "L-asparagine anabolism" EXACT [GOC:mah] +synonym: "L-asparagine biosynthesis" EXACT [GOC:mah] +synonym: "L-asparagine formation" EXACT [GOC:mah] +synonym: "L-asparagine synthesis" EXACT [GOC:mah] +is_a: GO:0006529 ! asparagine biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0070982 ! L-asparagine metabolic process + +[Term] +id: GO:0070982 +name: L-asparagine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-asparagine, (2S)-2-amino-3-carbamoylpropanoic acid." [GOC:mah] +synonym: "L-asparagine metabolism" EXACT [GOC:mah] +is_a: GO:0006528 ! asparagine metabolic process +is_a: GO:0043603 ! cellular amide metabolic process + +[Term] +id: GO:0070983 +name: dendrite guidance +namespace: biological_process +def: "The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:15046878] +synonym: "dendritic guidance" EXACT [GOC:sart] +is_a: GO:0097485 ! neuron projection guidance +relationship: part_of GO:0048813 ! dendrite morphogenesis + +[Term] +id: GO:0070984 +name: SET domain binding +namespace: molecular_function +def: "Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation." [GOC:sart, Pfam:PF00856, PMID:12575990] +synonym: "SET binding" EXACT [GOC:sart] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0070985 +name: transcription factor TFIIK complex +namespace: cellular_component +def: "A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7." [GOC:mah, PMID:19818408, PMID:22572993] +synonym: "cyclin H-CDK7 complex" RELATED [] +synonym: "Mcs6/Mcs2/Pmh1 complex" NARROW [GOC:vw, PMID:19328067] +synonym: "TFIIK complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex +relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex + +[Term] +id: GO:0070986 +name: left/right axis specification +namespace: biological_process +def: "The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes)." [GOC:dph, GOC:gvg, GOC:mah] +synonym: "left-right axis specification" EXACT [GOC:mah] +synonym: "left/right axis determination" RELATED [GOC:dph] +is_a: GO:0009798 ! axis specification +relationship: part_of GO:0060972 ! left/right pattern formation + +[Term] +id: GO:0070987 +name: error-free translesion synthesis +namespace: biological_process +def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level." [GOC:elh] +comment: Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. +is_a: GO:0019985 ! translesion synthesis + +[Term] +id: GO:0070988 +name: demethylation +namespace: biological_process +def: "The process of removing one or more methyl groups from a molecule." [GOC:BHF, GOC:rl] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0070989 +name: oxidative demethylation +namespace: biological_process +def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] +subset: goslim_chembl +is_a: GO:0070988 ! demethylation + +[Term] +id: GO:0070990 +name: snRNP binding +namespace: molecular_function +def: "Binding to a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:0070991 +name: medium-chain-acyl-CoA dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12." [GOC:BHF, GOC:mah] +synonym: "MCAD activity" EXACT [GOC:mah] +xref: EC:1.3.99.- +is_a: GO:0003995 ! acyl-CoA dehydrogenase activity + +[Term] +id: GO:0070992 +name: translation initiation complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd, GOC:mah] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070993 +name: translation preinitiation complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA." [GOC:hjd, GOC:mah] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0070994 +name: detection of oxidative stress +namespace: biological_process +def: "The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." [GOC:mah] +is_a: GO:0006979 ! response to oxidative stress + +[Term] +id: GO:0070995 +name: NADPH oxidation +namespace: biological_process +def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP." [GOC:BHF, GOC:mah] +synonym: "NADP (reduced) dehydrogenation" EXACT [GOC:mah] +synonym: "NADP (reduced) oxidation" EXACT [GOC:mah] +synonym: "NADPH dehydrogenation" EXACT [GOC:mah] +synonym: "reduced NADP dehydrogenation" EXACT [GOC:mah] +synonym: "reduced NADP oxidation" EXACT [GOC:mah] +synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenation" EXACT [GOC:mah] +synonym: "reduced nicotinamide adenine dinucleotide phosphate oxidation" EXACT [GOC:mah] +is_a: GO:0006739 ! NADP metabolic process + +[Term] +id: GO:0070996 +name: type 1 melanocortin receptor binding +namespace: molecular_function +def: "Binding to a type 1 melanocortin receptor." [GOC:BHF, GOC:mah] +synonym: "type 1 melanocortin receptor ligand" NARROW [GOC:mah] +is_a: GO:0031779 ! melanocortin receptor binding + +[Term] +id: GO:0070997 +name: neuron death +namespace: biological_process +def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah] +comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. +synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl] +synonym: "neuronal cell death" EXACT [GOC:mah] +is_a: GO:0008219 ! cell death + +[Term] +id: GO:0070998 +name: sensory perception of gravity +namespace: biological_process +def: "The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:mah] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0070999 +name: detection of mechanical stimulus involved in sensory perception of gravity +namespace: biological_process +def: "The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah] +is_a: GO:0009590 ! detection of gravity +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0070998 ! sensory perception of gravity + +[Term] +id: GO:0071000 +name: response to magnetism +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:sl] +synonym: "response to magnetic stimulus" EXACT [GOC:mah] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0071001 +name: U4/U6 snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0071002 +name: U4atac/U6atac snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes." [GOC:krc, GOC:mah, ISBN:0879695897, PMID:14685174] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0071003 +name: penta-snRNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins." [GOC:krc, GOC:mah, PMID:11804584, PMID:12724403] +synonym: "penta-RNP complex" EXACT [GOC:rb] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0071004 +name: U2-type prespliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] +synonym: "GT-AG prespliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "major prespliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "yeast U2-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071010 ! prespliceosome + +[Term] +id: GO:0071005 +name: U2-type precatalytic spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] +synonym: "GT-AG precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "major precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U2-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast U12-type spliceosomal complex A2-1" RELATED [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071011 ! precatalytic spliceosome + +[Term] +id: GO:0071006 +name: U2-type catalytic step 1 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] +synonym: "GT-AG catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "major catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U2-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "U2-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast U2-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071012 ! catalytic step 1 spliceosome + +[Term] +id: GO:0071007 +name: U2-type catalytic step 2 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] +synonym: "GT-AG catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "major catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U2-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast U2-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071013 ! catalytic step 2 spliceosome + +[Term] +id: GO:0071008 +name: U2-type post-mRNA release spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] +synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "U2/U5/U6 snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941, PMID:24442611] +synonym: "U2/U5/U6 tri-snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071014 ! post-mRNA release spliceosomal complex + +[Term] +id: GO:0071009 +name: U4atac/U6atac x U5 tri-snRNP complex +namespace: cellular_component +def: "A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs." [GOC:krc, GOC:mah, GOC:pr, ISBN:0879695897, PMID:16201866] +synonym: "U4atac/U6atac.U5 snRNP complex" EXACT [] +is_a: GO:0097526 ! spliceosomal tri-snRNP complex + +[Term] +id: GO:0071010 +name: prespliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex." [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890] +synonym: "mammalian spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "prespliceosomal complex" EXACT [GOC:vw] +synonym: "yeast spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0071011 +name: precatalytic spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] +synonym: "mammalian spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0071012 +name: catalytic step 1 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890] +synonym: "activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] +synonym: "mammalian spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0071013 +name: catalytic step 2 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890] +synonym: "mammalian spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0071014 +name: post-mRNA release spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0071015 +name: U12-type prespliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation." [GOC:ab, GOC:krc, GOC:mah, PMID:10197985, PMID:16201866] +synonym: "AT-AC prespliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex A" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "minor prespliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "yeast U12-type spliceosomal complex B" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071010 ! prespliceosome + +[Term] +id: GO:0071016 +name: U12-type precatalytic spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs." [GOC:ab, GOC:krc, GOC:mah, PMID:16201866] +synonym: "AT-AC precatalytic spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex B" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U12-type spliceosomal complex B1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "minor precatalytic spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "yeast U12-type spliceosomal complex A2-1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071011 ! precatalytic spliceosome + +[Term] +id: GO:0071017 +name: U12-type catalytic step 1 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] +synonym: "AT-AC catalytic step 1 spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex B*" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U12-type spliceosomal complex B2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "minor catalytic step 1 spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "U12-type activated spliceosome" EXACT [GOC:krc, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast U12-type spliceosomal complex A1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071012 ! catalytic step 1 spliceosome + +[Term] +id: GO:0071018 +name: U12-type catalytic step 2 spliceosome +namespace: cellular_component +def: "A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] +synonym: "AT-AC catalytic step 2 spliceosome" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex C" NARROW [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] +synonym: "mammalian U12-type spliceosomal complex C1" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "minor catalytic step 2 spliceosome" EXACT [GOC:krc, GOC:mah] +synonym: "yeast U12-type spliceosomal complex A2-2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071013 ! catalytic step 2 spliceosome + +[Term] +id: GO:0071019 +name: U12-type post-mRNA release spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:16201866] +synonym: "AT-AC post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "minor post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071014 ! post-mRNA release spliceosomal complex + +[Term] +id: GO:0071020 +name: post-spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "mammalian spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0071021 +name: U2-type post-spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "GT-AG post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] +synonym: "major post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] +synonym: "mammalian U2-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "yeast U2-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005684 ! U2-type spliceosomal complex +is_a: GO:0071020 ! post-spliceosomal complex + +[Term] +id: GO:0071022 +name: U12-type post-spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac." [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "AT-AC post-spliceosomal complex" NARROW [GOC:krc, GOC:mah] +synonym: "mammalian U12-type spliceosomal complex C2" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +synonym: "minor post-spliceosomal complex" EXACT [GOC:krc, GOC:mah] +synonym: "yeast U12-type spliceosomal complex A2-3" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] +is_a: GO:0005689 ! U12-type spliceosomal complex +is_a: GO:0071020 ! post-spliceosomal complex + +[Term] +id: GO:0071023 +name: trans spliceosomal complex +namespace: cellular_component +def: "A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates." [GOC:krc, ISBN:0879697393] +is_a: GO:0005681 ! spliceosomal complex + +[Term] +id: GO:0071024 +name: SL snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins." [GOC:krc, ISBN:0879697393] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0071025 +name: RNA surveillance +namespace: biological_process +def: "A process that identifies and degrades defective or aberrant RNAs." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "RNA quality control" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:0071026 +name: cytoplasmic RNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading defective or aberrant RNAs within the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "cytoplasmic aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "cytoplasmic RNA quality control" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0071025 ! RNA surveillance + +[Term] +id: GO:0071027 +name: nuclear RNA surveillance +namespace: biological_process +def: "A process that identifies and degrades defective or aberrant RNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "nuclear aberrant RNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear RNA quality control" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0071025 ! RNA surveillance + +[Term] +id: GO:0071028 +name: nuclear mRNA surveillance +namespace: biological_process +alt_id: GO:0071033 +alt_id: GO:0071048 +alt_id: GO:0071049 +def: "A process that identifies and degrades defective or aberrant mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:11586364, PMID:12417728, PMID:14718167, PMID:18644474] +synonym: "nuclear aberrant mRNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear mRNA quality control" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear retention of pre-mRNA at the site of transcription" NARROW [] +synonym: "nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription" NARROW [] +synonym: "nuclear retention of unspliced pre-mRNA at the site of transcription" NARROW [] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +is_a: GO:0071027 ! nuclear RNA surveillance + +[Term] +id: GO:0071029 +name: nuclear ncRNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "nuclear aberrant ncRNA catabolic process" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear ncRNA quality control" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0034661 ! ncRNA catabolic process +is_a: GO:0071027 ! nuclear RNA surveillance + +[Term] +id: GO:0071030 +name: nuclear mRNA surveillance of spliceosomal pre-mRNA splicing +namespace: biological_process +def: "The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "nuclear mRNA quality control of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear RNA catabolic process of incorrectly spliced pre-mRNA" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0071028 ! nuclear mRNA surveillance + +[Term] +id: GO:0071031 +name: nuclear mRNA surveillance of mRNA 3'-end processing +namespace: biological_process +def: "The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "nuclear mRNA catabolic process of mRNA with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear mRNA quality control of mRNAs with aberrant 3'-ends" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0071028 ! nuclear mRNA surveillance + +[Term] +id: GO:0071032 +name: nuclear mRNA surveillance of mRNP export +namespace: biological_process +def: "The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm." [GOC:dgf, GOC:krc, PMID:18644474] +synonym: "nuclear mRNA catabolic process of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] +synonym: "nuclear mRNA quality control of mRNAs in aberrant mRNPs" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0071028 ! nuclear mRNA surveillance + +[Term] +id: GO:0071034 +name: CUT catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs)." [GOC:dgf, GOC:krc] +synonym: "cryptic unstable transcript catabolic process" EXACT [GOC:dgf, GOC:krc] +is_a: GO:0034661 ! ncRNA catabolic process +is_a: GO:0071043 ! CUT metabolic process + +[Term] +id: GO:0071035 +name: nuclear polyadenylation-dependent rRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA." [GOC:dgf, GOC:krc, PMID:15173578, PMID:15572680, PMID:15935758, PMID:17652137, PMID:18591258] +synonym: "nuclear poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0016075 ! rRNA catabolic process +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0071036 +name: nuclear polyadenylation-dependent snoRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA." [GOC:dgf, GOC:krc, PMID:15935758] +synonym: "nuclear poly(A)-dependent snoRNA catabolic process" RELATED [GOC:tb] +is_a: GO:0016077 ! sno(s)RNA catabolic process +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0071037 +name: nuclear polyadenylation-dependent snRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA." [GOC:dgf, GOC:krc] +synonym: "nuclear poly(A)-dependent snRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0016076 ! snRNA catabolic process +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0071038 +name: nuclear polyadenylation-dependent tRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." [GOC:dgf, GOC:krc] +synonym: "nuclear poly(A)-dependent tRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process +is_a: GO:0106354 ! tRNA surveillance + +[Term] +id: GO:0071039 +name: nuclear polyadenylation-dependent CUT catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436, PMID:16973437, PMID:18007593, PMID:18591258] +synonym: "nuclear poly(A)-dependent CUT catabolic process" RELATED [GOC:vw] +is_a: GO:0071034 ! CUT catabolic process +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0071040 +name: nuclear polyadenylation-dependent antisense transcript catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript." [GOC:dgf, GOC:krc, PMID:18022365] +synonym: "nuclear poly(A)-dependent antisense transcript catabolic process" RELATED [GOC:vw] +is_a: GO:0071041 ! antisense RNA transcript catabolic process +is_a: GO:0071046 ! nuclear polyadenylation-dependent ncRNA catabolic process + +[Term] +id: GO:0071041 +name: antisense RNA transcript catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product." [GOC:dgf, GOC:krc] +is_a: GO:0034661 ! ncRNA catabolic process +is_a: GO:0042868 ! antisense RNA metabolic process + +[Term] +id: GO:0071042 +name: nuclear polyadenylation-dependent mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc, PMID:15145828, PMID:15828860, PMID:16431988, PMID:17643380, PMID:18000032, PMID:18644474] +synonym: "nuclear poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0071047 ! polyadenylation-dependent mRNA catabolic process + +[Term] +id: GO:0071043 +name: CUT metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome." [GOC:dgf, GOC:krc, PMID:15935759, PMID:16973436] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0071044 +name: histone mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA)." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] +is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process +is_a: GO:0008334 ! histone mRNA metabolic process + +[Term] +id: GO:0071045 +name: nuclear histone mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus." [GOC:dgf, GOC:krc, PMID:17179095, PMID:17855393] +is_a: GO:0071044 ! histone mRNA catabolic process + +[Term] +id: GO:0071046 +name: nuclear polyadenylation-dependent ncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc, PMID:17410208] +synonym: "nuclear poly(A)-dependent ncRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0043634 ! polyadenylation-dependent ncRNA catabolic process +is_a: GO:0071029 ! nuclear ncRNA surveillance + +[Term] +id: GO:0071047 +name: polyadenylation-dependent mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:dgf, GOC:krc] +synonym: "poly(A)-dependent mRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0006402 ! mRNA catabolic process +is_a: GO:0043633 ! polyadenylation-dependent RNA catabolic process +is_a: GO:0061157 ! mRNA destabilization + +[Term] +id: GO:0071050 +name: sno(s)RNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation." [GOC:dgf, GOC:krc, PMID:18951092] +synonym: "snoRNA polyadenylation" NARROW [] +synonym: "sRNA polyadenylation" NARROW [] +is_a: GO:0031126 ! sno(s)RNA 3'-end processing +is_a: GO:0043629 ! ncRNA polyadenylation + +[Term] +id: GO:0071051 +name: polyadenylation-dependent snoRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA." [GOC:dgf, GOC:krc, PMID:18951092] +synonym: "poly(A)-dependent snoRNA 3'-end processing" RELATED [GOC:vw] +is_a: GO:0031126 ! sno(s)RNA 3'-end processing + +[Term] +id: GO:0071052 +name: alpha9-beta1 integrin-ADAM1 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1." [PMID:11882657] +synonym: "ITGA9-ITGB1-ADAM1 complex" NARROW [CORUM:2964] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071053 +name: alpha9-beta1 integrin-ADAM2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2." [PMID:11882657] +synonym: "ITGA9-ITGB1-ADAM2 complex" NARROW [CORUM:2441] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071054 +name: alpha9-beta1 integrin-ADAM3 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3." [PMID:11882657] +synonym: "ITGA9-ITGB1-ADAM3 complex" NARROW [CORUM:2965] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071055 +name: alpha9-beta1 integrin-ADAM9 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9." [PMID:11882657] +synonym: "ITGA9-ITGB1-ADAM9 complex" NARROW [CORUM:2440] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071056 +name: alpha9-beta1 integrin-ADAM15 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:11882657] +synonym: "ITGA9-ITGB1-ADAM15 complex" NARROW [CORUM:2445] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071057 +name: alphav-beta3 integrin-ADAM15 complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15." [PMID:10944520, PMID:11882657] +synonym: "ITGAV-ITGB3-ADAM15 complex" NARROW [CORUM:2359] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071058 +name: alpha3-beta1 integrin-CD151 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151." [PMID:10811835, PMID:11884516] +synonym: "ITGA3-ITGB1-CD151 complex" NARROW [CORUM:2400] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071059 +name: alpha6-beta1 integrin-CD151 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] +synonym: "ITGA6-ITGB1-CD151 complex" NARROW [CORUM:2411] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071060 +name: alpha7-beta1 integrin-CD151 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151." [PMID:11884516] +synonym: "ITGA7-ITGB1-CD151 complex" NARROW [CORUM:2395] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071061 +name: alpha6-beta4 integrin-CD151 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151." [PMID:10811835] +synonym: "ITGA6-ITGB4-CD151 complex" NARROW [CORUM:2320] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071062 +name: alphav-beta3 integrin-vitronectin complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin." [PMID:10835423] +synonym: "ITGAV-ITGB3-VTN complex" NARROW [CORUM:2826] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071063 +name: sensory perception of wind +namespace: biological_process +def: "The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal." [GOC:mah, PMID:19279637] +synonym: "perception of wind" EXACT [GOC:mah] +synonym: "sensory perception of air flow" EXACT [GOC:mah, PMID:19279637] +is_a: GO:0050954 ! sensory perception of mechanical stimulus + +[Term] +id: GO:0071064 +name: alphaE-beta7 integrin-E-cadherin complex +namespace: cellular_component +def: "A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin." [PMID:10837471] +synonym: "ITGAE-ITGB7-CDH1 complex" NARROW [CORUM:1834] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071065 +name: alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1." [PMID:10209034] +synonym: "ITGA9-ITGB1-VCAM1 complex" NARROW [CORUM:2442] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071066 +name: detection of mechanical stimulus involved in sensory perception of wind +namespace: biological_process +def: "The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal." [GOC:dos, GOC:mah, PMID:19279637] +synonym: "detection of mechanical stimulus involved in sensory perception of air flow" EXACT [GOC:mah] +synonym: "detection of wind" EXACT [GOC:mah] +synonym: "perception of wind, detection of mechanical stimulus" EXACT [GOC:mah] +synonym: "perception of wind, sensory detection of mechanical stimulus" EXACT [GOC:mah] +synonym: "perception of wind, sensory transduction of mechanical stimulus" EXACT [GOC:mah] +synonym: "sensory detection of mechanical stimulus during perception of wind" EXACT [GOC:mah] +synonym: "sensory transduction of mechanical stimulus during perception of wind" EXACT [GOC:mah] +synonym: "sensory transduction of wind" EXACT [GOC:mah] +is_a: GO:0050877 ! nervous system process +is_a: GO:0050974 ! detection of mechanical stimulus involved in sensory perception +relationship: part_of GO:0071063 ! sensory perception of wind + +[Term] +id: GO:0071067 +name: alphav-beta3 integrin-ADAM23 complex +namespace: cellular_component +def: "A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23." [PMID:10749942] +synonym: "ITGAV-ITGB3-ADAM23 complex" NARROW [CORUM:2364] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071068 +name: alpha9-beta1 integrin-ADAM12 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12." [PMID:10944520] +synonym: "ITGA9-ITGB1-ADAM12 complex" NARROW [CORUM:2447] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071069 +name: alpha4-beta1 integrin-thrombospondin-1 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1." [PMID:11980922] +synonym: "ITGA4-ITGB1-THBS1 complex" NARROW [CORUM:2426] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071070 +name: alpha4-beta1 integrin-thrombospondin-2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2." [PMID:11980922] +synonym: "ITGA4-ITGB1-THBS2 complex" NARROW [CORUM:2428] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071071 +name: regulation of phospholipid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] +synonym: "regulation of phospholipid anabolism" EXACT [GOC:mah] +synonym: "regulation of phospholipid biosynthesis" EXACT [GOC:mah] +synonym: "regulation of phospholipid formation" EXACT [GOC:mah] +synonym: "regulation of phospholipid synthesis" EXACT [GOC:mah] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0071072 +name: negative regulation of phospholipid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] +synonym: "down regulation of phospholipid biosynthetic process" EXACT [GOC:mah] +synonym: "down-regulation of phospholipid biosynthetic process" EXACT [GOC:ma] +synonym: "downregulation of phospholipid biosynthetic process" EXACT [GOC:mah] +synonym: "inhibition of phospholipid biosynthetic process" NARROW [GOC:mah] +synonym: "negative regulation of phospholipid anabolism" EXACT [GOC:mah] +synonym: "negative regulation of phospholipid biosynthesis" EXACT [GOC:mah] +synonym: "negative regulation of phospholipid formation" EXACT [GOC:mah] +synonym: "negative regulation of phospholipid synthesis" EXACT [GOC:mah] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0071073 +name: positive regulation of phospholipid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids." [GOC:mah] +synonym: "activation of phospholipid biosynthetic process" NARROW [GOC:mah] +synonym: "positive regulation of phospholipid anabolism" EXACT [GOC:mah] +synonym: "positive regulation of phospholipid biosynthesis" EXACT [GOC:mah] +synonym: "positive regulation of phospholipid formation" EXACT [GOC:mah] +synonym: "positive regulation of phospholipid synthesis" EXACT [GOC:mah] +synonym: "stimulation of phospholipid biosynthetic process" NARROW [GOC:mah] +synonym: "up regulation of phospholipid biosynthetic process" EXACT [GOC:mah] +synonym: "up-regulation of phospholipid biosynthetic process" EXACT [GOC:mah] +synonym: "upregulation of phospholipid biosynthetic process" EXACT [GOC:mah] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0008654 ! phospholipid biosynthetic process + +[Term] +id: GO:0071074 +name: eukaryotic initiation factor eIF2 binding +namespace: molecular_function +def: "Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation." [GOC:hjd] +is_a: GO:0031369 ! translation initiation factor binding + +[Term] +id: GO:0071075 +name: CUGBP1-eIF2 complex +namespace: cellular_component +def: "A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation." [PMID:16931514] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071076 +name: RNA 3' uridylation +namespace: biological_process +def: "The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule." [GOC:vw, PMID:19430462] +is_a: GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0071077 +name: adenosine 3',5'-bisphosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other." [GOC:mah] +synonym: "adenosine 3',5'-diphosphate transporter activity" EXACT [PubChem_Compound:159296] +synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity" EXACT [PubChem_Compound:159296] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity + +[Term] +id: GO:0071078 +name: fibronectin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion." [PMID:10684262] +synonym: "FN-TGM2 complex" NARROW [CORUM:2375] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071079 +name: alpha2-beta1 integrin-chondroadherin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin." [PMID:9281592] +synonym: "ITGA2-ITGB1-CHAD complex" NARROW [CORUM:2430] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071080 +name: alpha3-beta1 integrin-basigin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin." [PMID:9360995] +synonym: "ITGA3-ITGB1-BSG complex" NARROW [CORUM:2398] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071081 +name: alpha3-beta1 integrin-CD63 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63." [PMID:7629079] +synonym: "ITGA3-ITGB1-CD63 complex" NARROW [CORUM:2399] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071082 +name: alpha9-beta1 integrin-tenascin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin." [PMID:9565552] +synonym: "ITGA9-ITGB1-TNC complex" NARROW [CORUM:2443] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071083 +name: alphaV-beta3 integrin-CD47-FCER2 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2)." [PMID:10037797] +synonym: "ITGAV-ITGB3-CD447-FCER2 complex" NARROW [CORUM:2355] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071084 +name: alpha2-beta1 integrin-CD47 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47." [PMID:10397731] +synonym: "ITGA2-ITGB1-CD47 complex" NARROW [CORUM:2429] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071085 +name: alphaIIb-beta3 integrin-CD9 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9." [PMID:10429193] +synonym: "ITGA2b-ITGB3-CD9 complex" NARROW [CORUM:2370] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071086 +name: alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib." [PMID:10429193] +synonym: "ITGA2b-ITGB3-CD9-GP1b-CD47 complex" NARROW [CORUM:2872] +is_a: GO:0090665 ! glycoprotein complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071087 +name: alpha11-beta1 integrin-collagen type I complex +namespace: cellular_component +def: "A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen." [PMID:10464311] +synonym: "ITGA11-ITGB1-COL1A1 complex" NARROW [CORUM:3059] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071088 +name: alpha5-beta1 integrin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] +synonym: "ITGA5-ITGB1-TGM2 complex" NARROW [CORUM:2433] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071089 +name: alphaV-beta3 integrin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase." [PMID:10684262] +synonym: "ITGAV-ITGB3-TGM2 complex" NARROW [CORUM:3095] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071090 +name: alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] +synonym: "ITGA2b-ITGB3-FN1-TGM2 complex" NARROW [CORUM:2376] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071091 +name: alpha1-beta1 integrin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] +synonym: "ITGA1-ITGB1-TGM2 complex" NARROW [CORUM:2894] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071092 +name: alpha3-beta1 integrin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase." [PMID:10684262] +synonym: "ITGA3-ITGB1-TGM2 complex" NARROW [CORUM:2402] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071093 +name: alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase." [PMID:10684262] +synonym: "ITGA5-ITGB1-FN1-TGM2 complex" NARROW [CORUM:2383] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071094 +name: alpha6-beta4 integrin-CD9 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9." [PMID:10711425] +synonym: "ITGA6-ITGB4-CD9 complex" NARROW [CORUM:2770] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071095 +name: alpha3-beta1 integrin-thrombospondin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin." [PMID:11358957] +synonym: "ITGA3-ITGB1-THBS1 complex" NARROW [CORUM:2401] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071096 +name: alphaV-beta3 integrin-gelsolin complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." [PMID:11577104] +synonym: "ITGAV-ITGB3-Gsn complex" NARROW [CORUM:2360] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071097 +name: alphaV-beta3 integrin-paxillin-Pyk2 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2." [PMID:11683411] +synonym: "ITGAV-ITGB3-PXN-PTK2b complex" NARROW [CORUM:2363] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071098 +name: alpha6-beta4 integrin-Fyn complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." [PMID:11684709] +synonym: "ITGA6-ITGB4-FYN complex" NARROW [CORUM:2321] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071099 +name: alphaV-beta6 integrin-TGFbeta-3 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3)." [PMID:11821050] +synonym: "ITGAV-ITGB6-TFGB3 complex" NARROW [CORUM:2353] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071100 +name: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." [PMID:11970960] +synonym: "ITGAV-ITGB8-MMP14-TGFB1 complex" NARROW [CORUM:2342] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071101 +name: alpha4-beta1 integrin-JAM2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2." [PMID:12070135] +synonym: "ITGA4-ITGB1-JAM2 complex" NARROW [CORUM:2422] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071102 +name: alpha4-beta1 integrin-paxillin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin." [PMID:12221126] +synonym: "ITGA4-ITGB1-PXN complex" NARROW [CORUM:2425] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071103 +name: DNA conformation change +namespace: biological_process +def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] +subset: goslim_metagenomics +synonym: "DNA conformation modification" EXACT [GOC:mah] +is_a: GO:0051276 ! chromosome organization + +[Term] +id: GO:0071104 +name: response to interleukin-9 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah, GOC:yaf] +synonym: "response to IL-9" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0071105 +name: response to interleukin-11 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah, GOC:yaf] +synonym: "response to IL-11" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0071106 +name: adenosine 3',5'-bisphosphate transmembrane transport +namespace: biological_process +def: "The process in which adenosine 3',5'-bisphosphate is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "adenosine 3',5'-bisphosphate membrane transport" EXACT [] +synonym: "adenosine 3',5'-diphosphate transport" EXACT [PubChem_Compound:159296] +synonym: "adenosine 3'-phosphate-5'-phosphate transmembrane transport" EXACT [PubChem_Compound:159296] +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:0071107 +name: response to parathyroid hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah, GOC:yaf] +synonym: "response to parathyroid hormone stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0071108 +name: protein K48-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein." [GOC:mah] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0071109 +name: superior temporal gyrus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus." [FMA:61905, GOC:BHF, GOC:mah, PMID:11484000] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0021987 ! cerebral cortex development + +[Term] +id: GO:0071110 +name: histone biotinylation +namespace: biological_process +def: "The modification of a histone by the addition of a biotinyl group." [GOC:rph, PMID:14613969, PMID:19019041] +is_a: GO:0009305 ! protein biotinylation +is_a: GO:0016570 ! histone modification + +[Term] +id: GO:0071111 +name: cyclic-guanylate-specific phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+)." [EC:3.1.4.52, RHEA:24902] +synonym: "c-di-GMP phosphodiesterase activity" RELATED [EC:3.1.4.52] +synonym: "c-di-GMP-specific phosphodiesterase activity" RELATED [EC:3.1.4.52] +synonym: "cyclic bis(3->5')diguanylate phosphodiesterase activity" RELATED [EC:3.1.4.52] +synonym: "PDEA1" RELATED [EC:3.1.4.52] +synonym: "phosphodiesterase A1 activity" RELATED [EC:3.1.4.52] +synonym: "VieA" RELATED [EC:3.1.4.52] +xref: EC:3.1.4.52 +xref: KEGG_REACTION:R08991 +xref: MetaCyc:RXN0-4181 +xref: RHEA:24902 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0071112 +name: alpha4-beta4 integrin-EMILIN-1 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN)." [PMID:12456677] +synonym: "ITGA4-ITGB4-EMILIN1 complex" NARROW [CORUM:2417] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071113 +name: alphaIIb-beta3 integrin-ICAM-4 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4." [PMID:12477717] +synonym: "ITGAIIb-ITGB3-ICAM4 complex" NARROW [CORUM:3115] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071114 +name: alphaV-beta3 integrin-tumstatin complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen." [PMID:12682293] +synonym: "ITGAV-ITGB3-COL4A3 complex" NARROW [CORUM:2365] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071115 +name: alpha5-beta1 integrin-endostatin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen." [PMID:12682293] +synonym: "ITGA5-ITGB1-CAL4A3 complex" NARROW [CORUM:2853] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071116 +name: alpha6-beta1 integrin-CYR61 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis." [PMID:12826661] +synonym: "ITGA6-ITGB1-CYR61 complex" NARROW [CORUM:2437] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071117 +name: alpha5-beta1 integrin-fibronectin-NOV complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV." [PMID:12902636] +synonym: "ITGA5-ITGB1-FN-1-NOV complex" NARROW [CORUM:2850] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071118 +name: alphaV-beta3 integrin-NOV complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV." [PMID:12902636] +synonym: "ITGAV-ITGB3-FN-1-NOV complex" NARROW [CORUM:2849] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071119 +name: alpha7-beta1 integrin-nicotinamide riboside kinase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP)." [PMID:12941630] +synonym: "ITGA7-ITGB1-ITGB1BP3 complex" NARROW [CORUM:2397] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071120 +name: alpha4-beta1 integrin-CD47 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47." [PMID:15292185] +synonym: "ITGA4-ITGB1-CB47 complex" NARROW [CORUM:2423] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071121 +name: alpha9-beta1 integrin-VEGF-D complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D." [PMID:15590642] +synonym: "ITGA9-ITGB1-FIGF complex" NARROW [CORUM:2446] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071122 +name: alpha9-beta1 integrin-VEGF-A complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A." [PMID:17363377] +synonym: "ITGA9-ITGB1-VEGFA complex" NARROW [CORUM:2972] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071123 +name: alpha9-beta1 integrin-VEGF-C complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C." [PMID:15590642] +synonym: "ITGA9-ITGB1-VEGFC complex" NARROW [CORUM:2971] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071124 +name: alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2." [PMID:15592458] +synonym: "ITGA1-ITGB1-PTPN2 complex" NARROW [CORUM:2435] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071125 +name: alphaV-beta3 integrin-EGFR complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor." [PMID:15834425] +synonym: "ITGAV-ITGB3-EGFR complex" NARROW [CORUM:2369] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071126 +name: alphaV-beta6 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin." [PMID:16005200] +synonym: "ITGAV-ITGB6-SPP1 complex" NARROW [CORUM:2352] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071127 +name: alpha9-beta1 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin." [PMID:16005200] +synonym: "ITGA9-ITGB1-SPP1 complex" NARROW [CORUM:3111] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071128 +name: alpha5-beta1 integrin-osteopontin complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin." [PMID:16005200] +synonym: "ITGA5-ITGB1-SPP1 complex" NARROW [CORUM:3112] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071129 +name: alphaV-beta3 integrin-LPP3 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] +synonym: "ITGAV-ITGB3-PPAP2B complex" NARROW [CORUM:2366] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071130 +name: alpha5-beta1 integrin-LPP3 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3." [PMID:16099422] +synonym: "ITGA5-ITGB1-PPAP2B complex" NARROW [CORUM:2386] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071131 +name: alphaV-beta3 integrin-laminin alpha-4 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." [PMID:16824487] +synonym: "ITGAV-ITGB3-LAMA4 complex" NARROW [CORUM:2374] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071132 +name: alphaX-beta2 integrin-ICAM-4 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4." [PMID:16985175] +synonym: "ITGAX-ITGB2-ICAM4 complex" NARROW [CORUM:3114] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071133 +name: alpha9-beta1 integrin-ADAM8 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8." [PMID:16995821] +synonym: "ITGA9-ITGB1-ADAM8 complex" NARROW [CORUM:2989] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071134 +name: alpha9-beta1 integrin-thrombospondin-1 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1." [PMID:17413041] +synonym: "ITGA9-ITGB1-THBS1 complex" NARROW [CORUM:2967] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071135 +name: alpha7-beta1 integrin-focal adhesion kinase complex +namespace: cellular_component +def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase." [PMID:17598176] +synonym: "ITGA7-ITGB1-PTK2 complex" NARROW [CORUM:3106] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071136 +name: alpha7-beta1 integrin-laminin alpha-2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2." [PMID:17598176] +synonym: "ITGA7-ITGB1-LAMA2 complex" NARROW [CORUM:3105] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071137 +name: alphaV-beta3 integrin-CD98 complex +namespace: cellular_component +def: "A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98." [PMID:18032696] +synonym: "ITGAV-ITGB3-SLC3A2 complex" NARROW [CORUM:3103] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071138 +name: alpha5-beta5-fibronectin-SFRP2 complex +namespace: cellular_component +def: "A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2." [PMID:14709558] +synonym: "ITGA5-ITGB5-FN-1-SFRP2 complex" NARROW [CORUM:2388] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071139 +name: resolution of recombination intermediates +namespace: biological_process +def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006310 ! DNA recombination + +[Term] +id: GO:0071140 +name: resolution of mitotic recombination intermediates +namespace: biological_process +def: "The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, GOC:mah, GOC:vw] +is_a: GO:0071139 ! resolution of recombination intermediates +relationship: part_of GO:0006312 ! mitotic recombination + +[Term] +id: GO:0071141 +name: SMAD protein complex +namespace: cellular_component +def: "A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven." [GOC:bhm, GOC:mah, PMID:9670020] +synonym: "SMAD complex" EXACT [GOC:mah] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0071142 +name: homomeric SMAD protein complex +namespace: cellular_component +alt_id: GO:0071143 +def: "A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive." [GOC:bhm, GOC:mah, PMID:11779505, PMID:16322555, PMID:9670020] +synonym: "SMAD1 homotrimer complex" NARROW [] +synonym: "SMAD1 protein complex" NARROW [] +synonym: "SMAD2 homotrimer complex" NARROW [] +synonym: "SMAD2 protein complex" NARROW [] +synonym: "SMAD3 homotrimer complex" NARROW [CORUM:3003] +synonym: "SMAD3 protein complex" NARROW [] +is_a: GO:0071141 ! SMAD protein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071144 +name: heteromeric SMAD protein complex +namespace: cellular_component +alt_id: GO:0071145 +alt_id: GO:0071146 +def: "A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric." [GOC:bhm, GOC:mah, PMID:11779505, PMID:15350224, PMID:16322555, PMID:9389648, PMID:9670020] +synonym: "SMAD1-SMAD4 protein complex" NARROW [] +synonym: "SMAD2-SMAD3-SMAD4 protein complex" NARROW [] +synonym: "SMAD2-SMAD4 protein complex" NARROW [CORUM:3001] +synonym: "SMAD3-SMAD4 protein complex" NARROW [] +is_a: GO:0071141 ! SMAD protein complex +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0071152 +name: G-protein alpha(q)-synembrin complex +namespace: cellular_component +def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] +synonym: "Ric-8A G(q) alpha subunit complex" NARROW [CORUM:175] +is_a: GO:0140535 ! intracellular protein-containing complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0071153 +name: G-protein alpha(o)-synembrin complex +namespace: cellular_component +def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] +synonym: "Ric-8A G(o) alpha-1 subunit complex" NARROW [CORUM:172] +synonym: "Ric-8A G(o) alpha-2 subunit complex" NARROW [CORUM:174] +is_a: GO:0140535 ! intracellular protein-containing complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:0071154 +name: G-protein alpha(i)1-synembrin complex +namespace: cellular_component +def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] +synonym: "Ric-8A G(i) alpha-1 subunit complex" NARROW [CORUM:170] +synonym: "Ric-8A G(i) alpha-2 subunit complex" RELATED [CORUM:171] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0071155 +name: G-protein alpha(13)-synembrin complex +namespace: cellular_component +def: "A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein." [GOC:mah, PMID:12509430] +synonym: "Ric-8A G alpha 13 subunit complex" NARROW [CORUM:176] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0071159 +name: NF-kappaB complex +namespace: cellular_component +def: "A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression." [ISBN:0849327946] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071160 +name: cyanophycin synthetase activity (L-aspartate-adding) +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp." [EC:6.3.2.29] +xref: EC:6.3.2.29 +xref: RHEA:13277 +is_a: GO:0043860 ! cyanophycin synthetase activity + +[Term] +id: GO:0071161 +name: cyanophycin synthetase activity (L-arginine-adding) +namespace: molecular_function +def: "Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1." [EC:6.3.2.30] +xref: EC:6.3.2.30 +xref: RHEA:23888 +is_a: GO:0043860 ! cyanophycin synthetase activity + +[Term] +id: GO:0071162 +name: CMG complex +namespace: cellular_component +def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] +synonym: "unwindosome" EXACT [PMID:19228417] +is_a: GO:0031261 ! DNA replication preinitiation complex +relationship: part_of GO:0000228 ! nuclear chromosome + +[Term] +id: GO:0071163 +name: DNA replication preinitiation complex assembly +namespace: biological_process +alt_id: GO:1902293 +alt_id: GO:1902316 +def: "The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity." [GOC:mah, PMID:28209641] +synonym: "DNA replication preinitiation complex formation" EXACT [GOC:mah] +synonym: "pre-IC complex assembly" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:0071164 +name: RNA trimethylguanosine synthase activity +namespace: molecular_function +def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [GOC:BHF, PMID:11983179, PMID:18775984] +synonym: "cap hypermethylase activity" EXACT [PMID:11983179] +synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl] +synonym: "snRNA methyltransferase activity" RELATED [GOC:rl] +is_a: GO:0008173 ! RNA methyltransferase activity + +[Term] +id: GO:0071165 +name: GINS complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks." [GOC:mah, PMID:16990792] +is_a: GO:0071163 ! DNA replication preinitiation complex assembly + +[Term] +id: GO:0071166 +name: ribonucleoprotein complex localization +namespace: biological_process +def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] +synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah] +synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah] +synonym: "RNP localization" EXACT [GOC:mah] +is_a: GO:0051641 ! cellular localization + +[Term] +id: GO:0071167 +name: obsolete ribonucleoprotein complex import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex from the cytoplasm to the nucleus." [GOC:BHF, GOC:mah] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "ribonucleoprotein complex import into cell nucleus" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex nucleus import" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex targeting to nucleus" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex transport from cytoplasm to nucleus" EXACT [GOC:mah] +synonym: "ribonucleoprotein import into nucleus" EXACT [GOC:rl] +synonym: "RNP import into nucleus" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0071168 +name: protein localization to chromatin +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] +synonym: "protein localisation to chromatin" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:0071169 +name: establishment of protein localization to chromatin +namespace: biological_process +def: "The directed movement of a protein to a part of a chromosome that is organized into chromatin." [GOC:mah] +synonym: "establishment of protein localisation to chromatin" EXACT [GOC:mah] +is_a: GO:0070199 ! establishment of protein localization to chromosome +is_a: GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:0071170 +name: site-specific DNA replication termination +namespace: biological_process +def: "A DNA replication termination process that takes place at a specific termination site." [GOC:mah, PMID:12009298, PMID:18723894] +comment: See also the biological process term 'replication fork arrest ; GO:0043111' and its children. +is_a: GO:0006274 ! DNA replication termination + +[Term] +id: GO:0071171 +name: site-specific DNA replication termination at RTS1 barrier +namespace: biological_process +def: "A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching." [GOC:vw, PMID:12009298, PMID:18723894] +is_a: GO:0022414 ! reproductive process +is_a: GO:0071170 ! site-specific DNA replication termination +relationship: part_of GO:0071516 ! establishment of imprinting at mating-type locus + +[Term] +id: GO:0071172 +name: dihydromonapterin reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+." [GOC:imk, PMID:19897652] +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0071173 +name: spindle assembly checkpoint signaling +namespace: biological_process +alt_id: GO:0072486 +def: "A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic). +subset: gocheck_do_not_manually_annotate +synonym: "SAC" BROAD [GOC:mah] +synonym: "signal transduction involved in spindle assembly checkpoint" EXACT [] +synonym: "spindle assembly checkpoint" EXACT [] +is_a: GO:0031577 ! spindle checkpoint signaling + +[Term] +id: GO:0071174 +name: mitotic spindle checkpoint signaling +namespace: biological_process +alt_id: GO:0072477 +def: "A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints). +subset: gocheck_do_not_manually_annotate +synonym: "mitotic cell cycle spindle checkpoint" EXACT [] +synonym: "mitotic spindle checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic cell cycle spindle checkpoint" EXACT [] +synonym: "signal transduction involved in mitotic spindle checkpoint" EXACT [] +synonym: "topo II checkpoint" RELATED [] +synonym: "topoisomerase II checkpoint" RELATED [] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling +is_a: GO:0031577 ! spindle checkpoint signaling + +[Term] +id: GO:0071175 +name: MAML2-RBP-Jkappa-ICN1 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML2-RBP-Jkappa-Notch1 complex" EXACT [CORUM:1949] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071176 +name: MAML2-RBP-Jkappa-ICN2 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML2-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3217] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071177 +name: MAML2-RBP-Jkappa-ICN3 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML2-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3218] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071178 +name: MAML2-RBP-Jkappa-ICN4 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML2-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3219] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071179 +name: MAML3-RBP-Jkappa-ICN1 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML3-RBP-Jkappa-Notch1 complex" EXACT [CORUM:3220] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071180 +name: MAML3-RBP-Jkappa-ICN2 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML3-RBP-Jkappa-Notch2 complex" EXACT [CORUM:3221] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071181 +name: MAML3-RBP-Jkappa-ICN3 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML3-RBP-Jkappa-Notch3 complex" EXACT [CORUM:3222] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071182 +name: MAML3-RBP-Jkappa-ICN4 complex +namespace: cellular_component +def: "A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [PMID:12370315] +synonym: "MAML3-RBP-Jkappa-Notch4 complex" EXACT [CORUM:3223] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071183 +name: protocadherin-alpha-protocadherin-gamma complex +namespace: cellular_component +def: "A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0071184 +name: protocadherin-alpha-v4-protocadherin-gamma-a1 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdhga1-Pcdha4 complex" NARROW [CORUM:1014] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071185 +name: protocadherin-alpha-v4-protocadherin-gamma-a3 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdhga1-Pcdhga3 complex" NARROW [CORUM:1016] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071186 +name: protocadherin-alpha-v4-protocadherin-gamma-b2 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdhga1-Pcdhgb2 complex" NARROW [CORUM:1015] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071187 +name: protocadherin-alpha-v4-protocadherin-gamma-b4 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdhga1-Pcdhgb4 complex" NARROW [CORUM:1017] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071188 +name: protocadherin-alpha-v7-protocadherin-gamma-a1 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdha7-Pcdhga1 complex" NARROW [CORUM:1021] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071189 +name: protocadherin-alpha-v7-protocadherin-gamma-a3 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdha7-Pcdhga3 complex" NARROW [CORUM:1019] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071190 +name: protocadherin-alpha-v7-protocadherin-gamma-b2 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdha7-Pcdhgb4 complex" NARROW [CORUM:1018] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071191 +name: protocadherin-alpha-v7-protocadherin-gamma-b4 complex +namespace: cellular_component +def: "A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane." [PMID:15347688] +synonym: "Pcdha7-Pcdhgb2 complex" NARROW [CORUM:1020] +is_a: GO:0071183 ! protocadherin-alpha-protocadherin-gamma complex + +[Term] +id: GO:0071192 +name: Kv4.2-KChIP1 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] +xref: CORUM:606 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071193 +name: Kv4.2-KChIP2 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] +xref: CORUM:607 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071194 +name: Kv4.2-KChIP3 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] +xref: CORUM:608 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071195 +name: Kv4.2-KChIP4 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:15356203] +xref: CORUM:3090 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071196 +name: Kv4.3-KChIP1 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15356203] +xref: CORUM:3091 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071197 +name: Kv4.2-Kv4.3 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3." [PMID:15356203] +xref: CORUM:609 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071198 +name: Kv4.1-DPP6 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] +synonym: "Kv4.1-DPPX channel complex" EXACT [PMID:15911355] +xref: CORUM:600 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071199 +name: Kv4.1-DPP10 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1." [PMID:15911355] +synonym: "Kv4.1-DPPY channel complex" EXACT [PMID:15911355] +xref: CORUM:601 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071200 +name: Kv4.2-DPP6 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2." [PMID:12575952, PMID:15911355] +synonym: "Kv4.2-DPPX channel complex" EXACT [PMID:15911355] +xref: CORUM:603 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071201 +name: Kv4.3-DPP6 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:12575952, PMID:15911355] +synonym: "Kv4.3-DPPX channel complex" EXACT [PMID:15911355] +xref: CORUM:599 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071202 +name: Kv4.3-DPP10 channel complex +namespace: cellular_component +def: "A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3." [PMID:15911355] +synonym: "Kv4.3-DPPY channel complex" EXACT [PMID:15911355] +xref: CORUM:598 +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0071203 +name: WASH complex +namespace: cellular_component +def: "A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53." [GOC:sp, PMID:19922875] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071204 +name: histone pre-mRNA 3'end processing complex +namespace: cellular_component +def: "A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1." [GOC:mah, PMID:19470752] +synonym: "histone 3'end pre-mRNA complex" EXACT [GOC:mah] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:0071205 +name: protein localization to juxtaparanode region of axon +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] +synonym: "protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0099612 ! protein localization to axon + +[Term] +id: GO:0071206 +name: establishment of protein localization to juxtaparanode region of axon +namespace: biological_process +def: "The directed movement of a protein to the juxtaparanode region of an axon." [GOC:BHF, GOC:mah] +synonym: "establishment of protein localisation to juxtaparanode region of axon" EXACT [GOC:mah] +is_a: GO:0045184 ! establishment of protein localization +is_a: GO:0071205 ! protein localization to juxtaparanode region of axon + +[Term] +id: GO:0071207 +name: histone pre-mRNA stem-loop binding +namespace: molecular_function +def: "Binding to a conserved stem-loop structure found in histone pre-mRNAs." [PMID:19470752] +is_a: GO:0036002 ! pre-mRNA binding + +[Term] +id: GO:0071208 +name: histone pre-mRNA DCP binding +namespace: molecular_function +def: "Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing." [PMID:19470752] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0071209 +name: U7 snRNA binding +namespace: molecular_function +def: "Binding to a U7 small nuclear RNA (U7 snRNA)." [GOC:mah, PMID:12975319] +comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0071210 +name: protein insertion into membrane raft +namespace: biological_process +def: "The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] +synonym: "establishment of protein localization to membrane raft" BROAD [GOC:mah, GOC:vw] +is_a: GO:0051205 ! protein insertion into membrane +is_a: GO:1903044 ! protein localization to membrane raft +relationship: part_of GO:0031579 ! membrane raft organization + +[Term] +id: GO:0071211 +name: protein targeting to vacuole involved in autophagy +namespace: biological_process +def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring as part of autophagy, the process in which cells digest parts of their own cytoplasm." [GOC:mah] +synonym: "protein targeting to autophagosome" RELATED [GOC:pad] +is_a: GO:0006623 ! protein targeting to vacuole +relationship: part_of GO:0006914 ! autophagy + +[Term] +id: GO:0071212 +name: subsynaptic reticulum +namespace: cellular_component +def: "An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:1460464, PMID:18171947, PMID:19244343, PMID:7946331] +synonym: "SSR" EXACT [PMID:19244343] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0061174 ! type I terminal bouton + +[Term] +id: GO:0071213 +name: cellular response to 1-aminocyclopropane-1-carboxylic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:mah] +is_a: GO:0009961 ! response to 1-aminocyclopropane-1-carboxylic acid +is_a: GO:0071230 ! cellular response to amino acid stimulus + +[Term] +id: GO:0071214 +name: cellular response to abiotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "cellular response to abiotic stress" NARROW [GOC:mah] +is_a: GO:0009628 ! response to abiotic stimulus +is_a: GO:0104004 ! cellular response to environmental stimulus + +[Term] +id: GO:0071215 +name: cellular response to abscisic acid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:mah] +is_a: GO:0009737 ! response to abscisic acid +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071216 +name: cellular response to biotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "cellular response to biotic stress" NARROW [GOC:mah] +is_a: GO:0009607 ! response to biotic stimulus +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0071217 +name: cellular response to external biotic stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:mah] +is_a: GO:0043207 ! response to external biotic stimulus +is_a: GO:0071216 ! cellular response to biotic stimulus +is_a: GO:0071496 ! cellular response to external stimulus + +[Term] +id: GO:0071218 +name: cellular response to misfolded protein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus." [GOC:mah] +is_a: GO:0035967 ! cellular response to topologically incorrect protein +is_a: GO:0051788 ! response to misfolded protein + +[Term] +id: GO:0071219 +name: cellular response to molecule of bacterial origin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:mah] +synonym: "cellular response to bacteria associated molecule" EXACT [GOC:mah] +synonym: "cellular response to bacterial associated molecule" EXACT [GOC:mah] +synonym: "cellular response to bacterium associated molecule" EXACT [GOC:mah] +is_a: GO:0002237 ! response to molecule of bacterial origin +is_a: GO:0071216 ! cellular response to biotic stimulus + +[Term] +id: GO:0071220 +name: cellular response to bacterial lipoprotein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:mah] +is_a: GO:0032493 ! response to bacterial lipoprotein +is_a: GO:0071219 ! cellular response to molecule of bacterial origin + +[Term] +id: GO:0071221 +name: cellular response to bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus." [GOC:mah] +is_a: GO:0070339 ! response to bacterial lipopeptide +is_a: GO:0071220 ! cellular response to bacterial lipoprotein + +[Term] +id: GO:0071222 +name: cellular response to lipopolysaccharide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:mah] +synonym: "cellular response to endotoxin" BROAD [GOC:mah, GOC:sl] +synonym: "cellular response to LPS" EXACT [GOC:mah] +is_a: GO:0032496 ! response to lipopolysaccharide +is_a: GO:0071219 ! cellular response to molecule of bacterial origin +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071223 +name: cellular response to lipoteichoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor." [GOC:mah] +synonym: "cellular response to LTA" EXACT [GOC:mah] +is_a: GO:0070391 ! response to lipoteichoic acid +is_a: GO:0071219 ! cellular response to molecule of bacterial origin +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071224 +name: cellular response to peptidoglycan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:mah] +is_a: GO:0032494 ! response to peptidoglycan +is_a: GO:0071219 ! cellular response to molecule of bacterial origin +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071225 +name: cellular response to muramyl dipeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:mah] +is_a: GO:0032495 ! response to muramyl dipeptide +is_a: GO:1901653 ! cellular response to peptide + +[Term] +id: GO:0071226 +name: cellular response to molecule of fungal origin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:mah] +synonym: "cellular response to fungus associated molecule" EXACT [GOC:mah] +is_a: GO:0002238 ! response to molecule of fungal origin +is_a: GO:0071216 ! cellular response to biotic stimulus + +[Term] +id: GO:0071227 +name: cellular response to molecule of oomycetes origin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:mah] +synonym: "cellular response to oomycetes associated molecule" EXACT [GOC:mah] +is_a: GO:0002240 ! response to molecule of oomycetes origin +is_a: GO:0071216 ! cellular response to biotic stimulus +is_a: GO:0071310 ! cellular response to organic substance +relationship: part_of GO:0009620 ! response to fungus + +[Term] +id: GO:0071228 +name: cellular response to tumor cell +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:mah] +is_a: GO:0002347 ! response to tumor cell +is_a: GO:0071216 ! cellular response to biotic stimulus + +[Term] +id: GO:0071229 +name: cellular response to acid chemical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, Wikipedia:Acid] +comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. +subset: gocheck_do_not_manually_annotate +synonym: "cellular response to acid" BROAD [] +synonym: "cellular response to acid anion" RELATED [] +synonym: "cellular response to oxoanion" RELATED [] +is_a: GO:0001101 ! response to acid chemical +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071230 +name: cellular response to amino acid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [GOC:mah] +synonym: "cellular response to amino acid" EXACT [GOC:mah] +is_a: GO:0043200 ! response to amino acid +is_a: GO:0071229 ! cellular response to acid chemical +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071231 +name: cellular response to folic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus." [GOC:mah] +synonym: "response to folate" EXACT [GOC:mah] +synonym: "response to vitamin B9" EXACT [GOC:mah] +is_a: GO:0051593 ! response to folic acid +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071232 +name: cellular response to histidine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [GOC:mah] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0080052 ! response to histidine + +[Term] +id: GO:0071233 +name: cellular response to leucine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mah] +is_a: GO:0043201 ! response to leucine +is_a: GO:0071230 ! cellular response to amino acid stimulus + +[Term] +id: GO:0071234 +name: cellular response to phenylalanine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [GOC:mah] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0080053 ! response to phenylalanine + +[Term] +id: GO:0071235 +name: cellular response to proline +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:mah] +is_a: GO:0010238 ! response to proline +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071236 +name: cellular response to antibiotic +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:mah] +is_a: GO:0046677 ! response to antibiotic +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071237 +name: cellular response to bacteriocin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation." [GOC:mah] +is_a: GO:0046678 ! response to bacteriocin +is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:1901653 ! cellular response to peptide + +[Term] +id: GO:0071238 +name: cellular response to brefeldin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] +is_a: GO:0031001 ! response to brefeldin A +is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071239 +name: cellular response to streptomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [GOC:mah] +is_a: GO:0046679 ! response to streptomycin +is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071240 +name: cellular response to food +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:mah] +is_a: GO:0032094 ! response to food +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071241 +name: cellular response to inorganic substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071242 +name: cellular response to ammonium ion +namespace: biological_process +alt_id: GO:1903718 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23509267] +synonym: "cellular response to ammonia" EXACT [] +is_a: GO:0060359 ! response to ammonium ion +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0071243 +name: cellular response to arsenic-containing substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah] +synonym: "cellular response to arsenic" EXACT [] +is_a: GO:0046685 ! response to arsenic-containing substance +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071244 +name: cellular response to carbon dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:mah] +is_a: GO:0010037 ! response to carbon dioxide +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071245 +name: cellular response to carbon monoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus." [GOC:mah] +is_a: GO:0034465 ! response to carbon monoxide +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071246 +name: cellular response to chlorate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:mah] +is_a: GO:0010157 ! response to chlorate +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071247 +name: cellular response to chromate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus." [GOC:mah] +is_a: GO:0046687 ! response to chromate +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071248 +name: cellular response to metal ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] +synonym: "cellular response to heavy metal" NARROW [GOC:mah] +synonym: "cellular response to metal" EXACT [GOC:mah] +is_a: GO:0010038 ! response to metal ion +is_a: GO:0071241 ! cellular response to inorganic substance + +[Term] +id: GO:0071249 +name: cellular response to nitrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:mah] +is_a: GO:0010167 ! response to nitrate +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902170 ! cellular response to reactive nitrogen species + +[Term] +id: GO:0071250 +name: cellular response to nitrite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:mah] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0080033 ! response to nitrite +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902170 ! cellular response to reactive nitrogen species + +[Term] +id: GO:0071251 +name: cellular response to silicon dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus." [GOC:mah] +synonym: "cellular response to silica" EXACT [GOC:mah] +synonym: "cellular response to silox" EXACT [GOC:mah] +is_a: GO:0034021 ! response to silicon dioxide +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071252 +name: cellular response to sulfur dioxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [GOC:mah] +is_a: GO:0010477 ! response to sulfur dioxide +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071253 +name: connexin binding +namespace: molecular_function +def: "Binding to a connexin, any of a group of related proteins that assemble to form gap junctions." [GOC:mah, PMID:19864490] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0071254 +name: cytoplasmic U snRNP body +namespace: cellular_component +def: "A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies." [GOC:sart, PMID:17595295] +synonym: "U body" EXACT [GOC:sart, PMID:17595295] +synonym: "U-body" EXACT [GOC:mah] +is_a: GO:1990904 ! ribonucleoprotein complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071255 +name: Cvt vesicle assembly +namespace: biological_process +def: "A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI)." [GOC:rb, PMID:10966461, PMID:11085977] +synonym: "Cvt vesicle biosynthesis" RELATED [GOC:mah] +synonym: "Cvt vesicle formation" EXACT [GOC:mah] +synonym: "cytoplasm to vacuole targeting vesicle assembly" EXACT [] +synonym: "cytoplasm-to-vacuole targetin vesicle assembly" EXACT [] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0032258 ! cytoplasm to vacuole transport by the Cvt pathway + +[Term] +id: GO:0071256 +name: translocon complex +namespace: cellular_component +alt_id: GO:0031206 +def: "A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins." [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571] +subset: goslim_pir +synonym: "Sec complex-associated translocon complex" NARROW [GOC:mah] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0071257 +name: cellular response to electrical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus." [GOC:mah] +synonym: "cellular response to electricity" RELATED [GOC:mah] +is_a: GO:0051602 ! response to electrical stimulus +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071258 +name: cellular response to gravity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:mah] +synonym: "cellular response to gravitational stimulus" EXACT [GOC:mah] +is_a: GO:0009629 ! response to gravity +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071259 +name: cellular response to magnetism +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus." [GOC:mah] +synonym: "cellular response to magnetic stimulus" EXACT [GOC:mah] +is_a: GO:0071000 ! response to magnetism +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071260 +name: cellular response to mechanical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:mah] +synonym: "cellular mechanical stimulus response" EXACT [GOC:mah] +is_a: GO:0009612 ! response to mechanical stimulus +is_a: GO:0071214 ! cellular response to abiotic stimulus +is_a: GO:0071496 ! cellular response to external stimulus + +[Term] +id: GO:0071261 +name: Ssh1 translocon complex +namespace: cellular_component +def: "A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences." [GOC:mah, PMID:12134063, PMID:8612571] +synonym: "Ssh1p-Sss1p-Sbh2p complex" NARROW [GOC:mah] +is_a: GO:0071256 ! translocon complex + +[Term] +id: GO:0071262 +name: regulation of translational initiation in response to starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] +synonym: "regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] +is_a: GO:0043558 ! regulation of translational initiation in response to stress +relationship: part_of GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0071263 +name: negative regulation of translational initiation in response to starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment." [GOC:mah] +synonym: "down regulation of translation initiation in response to starvation" EXACT [GOC:mah] +synonym: "down-regulation of translation initiation in response to starvation" EXACT [GOC:mah] +synonym: "downregulation of translation initiation in response to starvation" EXACT [GOC:mah] +synonym: "inhibition of translation initiation in response to starvation" NARROW [GOC:mah] +synonym: "negative regulation of translational initiation in response to nutrient starvation" EXACT [GOC:vw] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0032057 ! negative regulation of translational initiation in response to stress +is_a: GO:0071262 ! regulation of translational initiation in response to starvation + +[Term] +id: GO:0071264 +name: positive regulation of translational initiation in response to starvation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment." [GOC:mah] +synonym: "activation of translation initiation in response to starvation" NARROW [GOC:mah] +synonym: "positive regulation of translational initiation in response to nutrient starvation" EXACT [GOC:mah] +synonym: "stimulation of translation initiation in response to starvation" NARROW [GOC:mah] +synonym: "up regulation of translation initiation in response to starvation" EXACT [GOC:mah] +synonym: "up-regulation of translation initiation in response to starvation" EXACT [GOC:mah] +synonym: "upregulation of translation initiation in response to starvation" EXACT [GOC:mah] +is_a: GO:0032056 ! positive regulation of translation in response to stress +is_a: GO:0032058 ! positive regulation of translational initiation in response to stress +is_a: GO:0071262 ! regulation of translational initiation in response to starvation + +[Term] +id: GO:0071265 +name: L-methionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid." [GOC:ecd] +synonym: "L-methionine anabolism" EXACT [GOC:mah] +synonym: "L-methionine biosynthesis" EXACT [GOC:mah] +synonym: "L-methionine formation" EXACT [GOC:mah] +synonym: "L-methionine synthesis" EXACT [GOC:mah] +is_a: GO:0009086 ! methionine biosynthetic process + +[Term] +id: GO:0071266 +name: 'de novo' L-methionine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components." [GOC:ecd] +synonym: "'de novo' L-methionine anabolism" EXACT [GOC:mah] +synonym: "'de novo' L-methionine biosynthesis" EXACT [GOC:mah] +synonym: "'de novo' L-methionine formation" EXACT [GOC:mah] +synonym: "'de novo' L-methionine synthesis" EXACT [GOC:mah] +is_a: GO:0071265 ! L-methionine biosynthetic process + +[Term] +id: GO:0071267 +name: L-methionine salvage +namespace: biological_process +def: "Any process that generates L-methionine from derivatives of it, without de novo synthesis." [GOC:ecd] +is_a: GO:0043102 ! amino acid salvage +is_a: GO:0071265 ! L-methionine biosynthetic process + +[Term] +id: GO:0071268 +name: homocysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." [GOC:ecd, GOC:mah] +synonym: "homocysteine anabolism" EXACT [GOC:mah] +synonym: "homocysteine biosynthesis" EXACT [GOC:mah] +synonym: "homocysteine formation" EXACT [GOC:mah] +synonym: "homocysteine synthesis" EXACT [GOC:mah] +is_a: GO:0000097 ! sulfur amino acid biosynthetic process +is_a: GO:0050667 ! homocysteine metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:0071269 +name: L-homocysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-homocysteine, the L-enantiomer of 2-amino-4-sulfanylbutanoic acid." [GOC:ecd, GOC:mah] +synonym: "L-homocysteine anabolism" EXACT [GOC:mah] +synonym: "L-homocysteine biosynthesis" EXACT [GOC:mah] +synonym: "L-homocysteine formation" EXACT [GOC:mah] +synonym: "L-homocysteine synthesis" EXACT [GOC:mah] +is_a: GO:0009070 ! serine family amino acid biosynthetic process +is_a: GO:0071268 ! homocysteine biosynthetic process + +[Term] +id: GO:0071270 +name: 1-butanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-butanol, an alkyl primary alcohol with the formula C4H10O." [GOC:ecd, GOC:mah] +synonym: "1-butanol metabolism" EXACT [GOC:mah] +synonym: "butan-1-ol metabolic process" EXACT [CHEBI:28885] +synonym: "butanol metabolic process" BROAD [GOC:mah] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:0071271 +name: 1-butanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O." [GOC:ecd, GOC:mah] +synonym: "1-butanol anabolism" EXACT [GOC:mah] +synonym: "1-butanol biosynthesis" EXACT [GOC:mah] +synonym: "1-butanol formation" EXACT [GOC:mah] +synonym: "1-butanol synthesis" EXACT [GOC:mah] +synonym: "butan-1-ol biosynthetic process" EXACT [CHEBI:28885] +synonym: "butanol biosynthetic process" BROAD [GOC:mah] +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0071270 ! 1-butanol metabolic process +is_a: GO:1903175 ! fatty alcohol biosynthetic process + +[Term] +id: GO:0071272 +name: morphine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:mah] +synonym: "morphine metabolism" EXACT [GOC:mah] +xref: Wikipedia:Morphine +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:0071273 +name: morphine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:ecd, GOC:mah] +synonym: "morphine breakdown" EXACT [GOC:mah] +synonym: "morphine catabolism" EXACT [GOC:mah] +synonym: "morphine degradation" EXACT [GOC:mah] +xref: UniPathway:Q02198 +is_a: GO:0071272 ! morphine metabolic process +is_a: GO:0071274 ! isoquinoline alkaloid catabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:0071274 +name: isoquinoline alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] +synonym: "ipecac alkaloid catabolism" RELATED [GOC:mah] +synonym: "isoquinoline alkaloid breakdown" EXACT [GOC:mah] +synonym: "isoquinoline alkaloid catabolism" EXACT [GOC:mah] +synonym: "isoquinoline alkaloid degradation" EXACT [GOC:mah] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0071275 +name: cellular response to aluminum ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:mah] +synonym: "cellular response to aluminium ion" EXACT [GOC:mah] +synonym: "cellular response to aluminum" EXACT [GOC:mah] +is_a: GO:0010044 ! response to aluminum ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071276 +name: cellular response to cadmium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah] +synonym: "cellular response to cadmium" EXACT [GOC:mah] +is_a: GO:0046686 ! response to cadmium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071277 +name: cellular response to calcium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] +synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] +is_a: GO:0051592 ! response to calcium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071278 +name: cellular response to cesium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:mah] +synonym: "cellular response to cesium" EXACT [GOC:mah] +is_a: GO:0010164 ! response to cesium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071279 +name: cellular response to cobalt ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] +is_a: GO:0032025 ! response to cobalt ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071280 +name: cellular response to copper ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah] +synonym: "cellular response to copper" EXACT [GOC:mah] +is_a: GO:0046688 ! response to copper ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071281 +name: cellular response to iron ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah] +synonym: "cellular response to iron" EXACT [GOC:mah] +is_a: GO:0010039 ! response to iron ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071282 +name: cellular response to iron(II) ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:mah] +synonym: "cellular response to iron(II)" EXACT [GOC:mah] +is_a: GO:0010040 ! response to iron(II) ion +is_a: GO:0071281 ! cellular response to iron ion + +[Term] +id: GO:0071283 +name: cellular response to iron(III) ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:mah] +synonym: "cellular response to iron(III)" EXACT [GOC:mah] +is_a: GO:0010041 ! response to iron(III) ion +is_a: GO:0071281 ! cellular response to iron ion + +[Term] +id: GO:0071284 +name: cellular response to lead ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:mah] +is_a: GO:0010288 ! response to lead ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071285 +name: cellular response to lithium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:mah] +is_a: GO:0010226 ! response to lithium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071286 +name: cellular response to magnesium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] +is_a: GO:0032026 ! response to magnesium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071287 +name: cellular response to manganese ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:mah] +synonym: "cellular response to manganese" EXACT [GOC:mah] +is_a: GO:0010042 ! response to manganese ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071288 +name: cellular response to mercury ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah] +synonym: "cellular response to mercuric ion" EXACT [GOC:mah] +synonym: "cellular response to mercury" EXACT [GOC:mah] +is_a: GO:0046689 ! response to mercury ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071289 +name: cellular response to nickel ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:mah] +synonym: "cellular response to nickel" EXACT [GOC:mah] +is_a: GO:0010045 ! response to nickel cation +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071290 +name: cellular response to platinum ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platinum stimulus." [GOC:mah] +synonym: "cellular response to platinum" EXACT [GOC:mah] +is_a: GO:0070541 ! response to platinum ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071291 +name: cellular response to selenium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mah] +is_a: GO:0010269 ! response to selenium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071292 +name: cellular response to silver ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah] +is_a: GO:0010272 ! response to silver ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071293 +name: cellular response to tellurium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus." [GOC:mah] +synonym: "cellular response to tellurium" EXACT [GOC:mah] +is_a: GO:0046690 ! response to tellurium ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071294 +name: cellular response to zinc ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah] +synonym: "cellular response to zinc" EXACT [GOC:mah] +is_a: GO:0010043 ! response to zinc ion +is_a: GO:0071248 ! cellular response to metal ion + +[Term] +id: GO:0071295 +name: cellular response to vitamin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah] +is_a: GO:0031670 ! cellular response to nutrient +is_a: GO:0033273 ! response to vitamin + +[Term] +id: GO:0071296 +name: cellular response to biotin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus." [GOC:mah] +synonym: "cellular response to Bios IIB" EXACT [GOC:sl] +synonym: "cellular response to coenzyme R" EXACT [GOC:sl] +synonym: "cellular response to vitamin B7" EXACT [GOC:sl] +synonym: "cellular response to vitamin H" EXACT [GOC:sl] +is_a: GO:0070781 ! response to biotin +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071297 +name: cellular response to cobalamin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus." [GOC:mah] +synonym: "cellular response to vitamin B12" EXACT [GOC:mah] +is_a: GO:0033590 ! response to cobalamin +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071298 +name: cellular response to L-ascorbic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus." [GOC:mah] +synonym: "cellular response to ascorbic acid" BROAD [GOC:mah] +synonym: "cellular response to L-ascorbate" EXACT [GOC:mah] +synonym: "cellular response to vitamin C" EXACT [GOC:mah] +is_a: GO:0033591 ! response to L-ascorbic acid +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071326 ! cellular response to monosaccharide stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071299 +name: cellular response to vitamin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus." [GOC:mah] +synonym: "cellular response to retinol" NARROW [GOC:mah] +is_a: GO:0033189 ! response to vitamin A +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071396 ! cellular response to lipid + +[Term] +id: GO:0071300 +name: cellular response to retinoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:mah] +synonym: "cellular response to vitamin A acid" EXACT [GOC:mah] +is_a: GO:0032526 ! response to retinoic acid +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071301 +name: cellular response to vitamin B1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah] +synonym: "cellular response to thiamin" EXACT [GOC:mah] +synonym: "cellular response to thiamine" EXACT [GOC:mah] +is_a: GO:0010266 ! response to vitamin B1 +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071302 +name: cellular response to vitamin B2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus." [GOC:mah] +synonym: "cellular response to riboflavin" EXACT [GOC:mah] +is_a: GO:0033274 ! response to vitamin B2 +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071303 +name: cellular response to vitamin B3 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus." [GOC:mah] +synonym: "cellular response to niacin" NARROW [GOC:mah] +synonym: "cellular response to nicotinamide" NARROW [GOC:mah] +is_a: GO:0033552 ! response to vitamin B3 +is_a: GO:0071295 ! cellular response to vitamin + +[Term] +id: GO:0071304 +name: cellular response to vitamin B6 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:mah] +is_a: GO:0034516 ! response to vitamin B6 +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071305 +name: cellular response to vitamin D +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus." [GOC:mah] +synonym: "cellular response to calciferol" EXACT [GOC:mah] +synonym: "cellular response to cholecalciferol" NARROW [GOC:mah] +synonym: "cellular response to ergocalciferol" NARROW [GOC:mah] +is_a: GO:0033280 ! response to vitamin D +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071306 +name: cellular response to vitamin E +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus." [GOC:mah] +synonym: "cellular response to DL-alpha-tocopherol acetate" NARROW [GOC:mah] +synonym: "cellular response to DL-alpha-tocopheryl acetate" NARROW [GOC:mah] +synonym: "cellular response to O-Acetyl-alpha-tocopherol" NARROW [GOC:mah] +is_a: GO:0033197 ! response to vitamin E +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071307 +name: cellular response to vitamin K +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:mah] +is_a: GO:0032571 ! response to vitamin K +is_a: GO:0071295 ! cellular response to vitamin +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071308 +name: cellular response to menaquinone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:mah] +synonym: "cellular response to menatetrenone" EXACT [GOC:mah] +synonym: "cellular response to vitamin K2" EXACT [GOC:mah] +is_a: GO:0032572 ! response to menaquinone +is_a: GO:0071307 ! cellular response to vitamin K +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071309 +name: cellular response to phylloquinone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:mah] +synonym: "cellular response to vitamin K1" EXACT [GOC:mah] +is_a: GO:0032573 ! response to phylloquinone +is_a: GO:0071307 ! cellular response to vitamin K + +[Term] +id: GO:0071310 +name: cellular response to organic substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] +is_a: GO:0010033 ! response to organic substance +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071311 +name: cellular response to acetate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:mah] +is_a: GO:0010034 ! response to acetate +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071312 +name: cellular response to alkaloid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah] +is_a: GO:0043279 ! response to alkaloid +is_a: GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0071313 +name: cellular response to caffeine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah] +is_a: GO:0031000 ! response to caffeine +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071415 ! cellular response to purine-containing compound + +[Term] +id: GO:0071314 +name: cellular response to cocaine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [GOC:mah] +is_a: GO:0042220 ! response to cocaine +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071315 +name: cellular response to morphine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [GOC:mah] +is_a: GO:0043278 ! response to morphine +is_a: GO:0071317 ! cellular response to isoquinoline alkaloid + +[Term] +id: GO:0071316 +name: cellular response to nicotine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus." [GOC:mah] +is_a: GO:0035094 ! response to nicotine +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071317 +name: cellular response to isoquinoline alkaloid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [GOC:mah] +is_a: GO:0014072 ! response to isoquinoline alkaloid +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071318 +name: cellular response to ATP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus." [GOC:mah] +synonym: "cellular response to adenosine 5'-triphosphate" EXACT [GOC:mah] +synonym: "cellular response to adenosine triphosphate" EXACT [GOC:mah] +is_a: GO:0033198 ! response to ATP +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071319 +name: cellular response to benzoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0080021 ! response to benzoic acid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071320 +name: cellular response to cAMP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah] +synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah] +synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah] +synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah] +synonym: "cellular response to cyclic AMP" EXACT [GOC:mah] +is_a: GO:0051591 ! response to cAMP +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071321 +name: cellular response to cGMP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus." [GOC:mah] +synonym: "cellular response to 3',5' cGMP" EXACT [GOC:mah] +synonym: "cellular response to 3',5'-cGMP" EXACT [GOC:mah] +synonym: "cellular response to cyclic GMP" EXACT [GOC:mah] +synonym: "cellular response to guanosine 3',5'-cyclophosphate" EXACT [GOC:mah] +is_a: GO:0070305 ! response to cGMP +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071322 +name: cellular response to carbohydrate stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] +is_a: GO:0009743 ! response to carbohydrate +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071323 +name: cellular response to chitin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:mah] +is_a: GO:0010200 ! response to chitin +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071324 +name: cellular response to disaccharide stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus." [GOC:mah] +is_a: GO:0034285 ! response to disaccharide +is_a: GO:0071322 ! cellular response to carbohydrate stimulus + +[Term] +id: GO:0071325 +name: cellular response to mannitol stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [GOC:mah] +is_a: GO:0010555 ! response to mannitol +is_a: GO:0071322 ! cellular response to carbohydrate stimulus + +[Term] +id: GO:0071326 +name: cellular response to monosaccharide stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] +is_a: GO:0034284 ! response to monosaccharide +is_a: GO:0071322 ! cellular response to carbohydrate stimulus + +[Term] +id: GO:0071327 +name: cellular response to trehalose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [GOC:mah] +is_a: GO:0010353 ! response to trehalose +is_a: GO:0071324 ! cellular response to disaccharide stimulus + +[Term] +id: GO:0071328 +name: cellular response to maltose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus." [GOC:mah] +is_a: GO:0034286 ! response to maltose +is_a: GO:0071324 ! cellular response to disaccharide stimulus + +[Term] +id: GO:0071329 +name: cellular response to sucrose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:mah] +is_a: GO:0009744 ! response to sucrose +is_a: GO:0071324 ! cellular response to disaccharide stimulus + +[Term] +id: GO:0071330 +name: cellular response to trehalose-6-phosphate stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [GOC:mah] +is_a: GO:0071324 ! cellular response to disaccharide stimulus +is_a: GO:0080094 ! response to trehalose-6-phosphate + +[Term] +id: GO:0071331 +name: cellular response to hexose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] +is_a: GO:0009746 ! response to hexose +is_a: GO:0071326 ! cellular response to monosaccharide stimulus + +[Term] +id: GO:0071332 +name: cellular response to fructose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:mah] +is_a: GO:0009750 ! response to fructose +is_a: GO:0071331 ! cellular response to hexose stimulus + +[Term] +id: GO:0071333 +name: cellular response to glucose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] +is_a: GO:0001678 ! cellular glucose homeostasis +is_a: GO:0009749 ! response to glucose +is_a: GO:0071331 ! cellular response to hexose stimulus + +[Term] +id: GO:0071334 +name: cellular response to rhamnose stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mah] +synonym: "cellular response to L-rhamnose stimulus" NARROW [GOC:mah] +is_a: GO:0032149 ! response to rhamnose +is_a: GO:0071331 ! cellular response to hexose stimulus + +[Term] +id: GO:0071335 +name: hair follicle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population." [GOC:rph, PMID:16086254] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0071336 +name: regulation of hair follicle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hair follicle cell proliferation." [GOC:mah] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0071335 ! hair follicle cell proliferation + +[Term] +id: GO:0071337 +name: negative regulation of hair follicle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of hair follicle cell proliferation." [GOC:mah] +synonym: "down regulation of hair follicle cell proliferation" EXACT [GOC:mah] +synonym: "down-regulation of hair follicle cell proliferation" EXACT [GOC:mah] +synonym: "downregulation of hair follicle cell proliferation" EXACT [GOC:mah] +synonym: "inhibition of hair follicle cell proliferation" NARROW [GOC:mah] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0071336 ! regulation of hair follicle cell proliferation +relationship: negatively_regulates GO:0071335 ! hair follicle cell proliferation + +[Term] +id: GO:0071338 +name: positive regulation of hair follicle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the rate or extent of hair follicle cell proliferation." [GOC:mah] +synonym: "activation of hair follicle cell proliferation" NARROW [GOC:mah] +synonym: "stimulation of hair follicle cell proliferation" NARROW [GOC:mah] +synonym: "up regulation of hair follicle cell proliferation" EXACT [GOC:mah] +synonym: "up-regulation of hair follicle cell proliferation" EXACT [GOC:mah] +synonym: "upregulation of hair follicle cell proliferation" EXACT [GOC:mah] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0071336 ! regulation of hair follicle cell proliferation +relationship: positively_regulates GO:0071335 ! hair follicle cell proliferation + +[Term] +id: GO:0071339 +name: MLL1 complex +namespace: cellular_component +def: "A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5." [GOC:sp, PMID:15960975] +is_a: GO:0044665 ! MLL1/2 complex + +[Term] +id: GO:0071340 +name: skeletal muscle acetylcholine-gated channel clustering +namespace: biological_process +def: "The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals." [GOC:bf, GOC:dsf, PMID:19285469] +synonym: "skeletal muscle AChR clustering" EXACT [GOC:mah] +synonym: "skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:bf] +is_a: GO:0043113 ! receptor clustering +relationship: part_of GO:0001941 ! postsynaptic membrane organization +relationship: part_of GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:0071341 +name: medial cortical node +namespace: cellular_component +def: "A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis." [GOC:mah, GOC:vw, PMID:19474789, PMID:19959363] +synonym: "mid1p medial cortical dot" EXACT [GOC:vw] +synonym: "midsome" EXACT [GOC:vw, PMID:19959363] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031097 ! medial cortex + +[Term] +id: GO:0071342 +name: regulation of establishment of actomyosin contractile ring localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] +synonym: "regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:1901648 ! regulation of actomyosin contractile ring localization +relationship: regulates GO:0032188 ! establishment of actomyosin contractile ring localization + +[Term] +id: GO:0071343 +name: obsolete negative regulation of establishment of actomyosin contractile ring localization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location." [GOC:mah] +comment: This term was made obsolete because it does not describe a wild-type or normal process. +synonym: "negative regulation of establishment of actomyosin contractile ring localization" EXACT [] +synonym: "negative regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] +synonym: "negative regulation of establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] +synonym: "negative regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] +is_obsolete: true + +[Term] +id: GO:0071344 +name: diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diphosphate, the anion or salt of diphosphoric acid." [GOC:pde] +synonym: "pyrophosphate metabolism" EXACT [GOC:mah] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0043436 ! oxoacid metabolic process + +[Term] +id: GO:0071345 +name: cellular response to cytokine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus." [GOC:mah] +is_a: GO:0034097 ! response to cytokine +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071346 +name: cellular response to interferon-gamma +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far." [GOC:mah] +synonym: "cellular response to gamma-interferon" RELATED [GOC:mah] +synonym: "cellular response to immune interferon" EXACT [GOC:mah] +synonym: "cellular response to type II IFN" BROAD [GOC:mah] +synonym: "cellular response to type II interferon" BROAD [GOC:mah] +is_a: GO:0034341 ! response to interferon-gamma +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071347 +name: cellular response to interleukin-1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus." [GOC:mah] +synonym: "cellular response to IL-1" EXACT [GOC:mah] +is_a: GO:0070555 ! response to interleukin-1 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071348 +name: cellular response to interleukin-11 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus." [GOC:mah] +synonym: "cellular response to IL-11" EXACT [GOC:mah] +is_a: GO:0071105 ! response to interleukin-11 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071349 +name: cellular response to interleukin-12 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus." [GOC:mah] +synonym: "cellular response to IL-12" EXACT [GOC:mah] +is_a: GO:0070671 ! response to interleukin-12 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071350 +name: cellular response to interleukin-15 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus." [GOC:mah] +synonym: "cellular response to IL-15" EXACT [GOC:mah] +is_a: GO:0070672 ! response to interleukin-15 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071351 +name: cellular response to interleukin-18 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus." [GOC:mah] +synonym: "cellular response to IL-18" EXACT [GOC:mah] +is_a: GO:0070673 ! response to interleukin-18 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071352 +name: cellular response to interleukin-2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus." [GOC:mah] +synonym: "cellular response to IL-2" EXACT [GOC:mah] +is_a: GO:0070669 ! response to interleukin-2 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071353 +name: cellular response to interleukin-4 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus." [GOC:mah] +synonym: "cellular response to IL-4" EXACT [GOC:mah] +is_a: GO:0070670 ! response to interleukin-4 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071354 +name: cellular response to interleukin-6 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." [GOC:mah] +synonym: "cellular response to IL-6" EXACT [GOC:mah] +is_a: GO:0070741 ! response to interleukin-6 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071355 +name: cellular response to interleukin-9 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus." [GOC:mah] +synonym: "cellular response to IL-9" EXACT [GOC:mah] +is_a: GO:0071104 ! response to interleukin-9 +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071356 +name: cellular response to tumor necrosis factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus." [GOC:mah] +synonym: "cellular response to TNF" EXACT [GOC:mah] +is_a: GO:0034612 ! response to tumor necrosis factor +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071357 +name: cellular response to type I interferon +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:mah] +synonym: "cellular response to type I IFN" EXACT [GOC:mah] +is_a: GO:0034340 ! response to type I interferon +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071358 +name: cellular response to type III interferon +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far." [GOC:mah] +synonym: "cellular response to interferon-lambda" NARROW [GOC:mah] +synonym: "cellular response to type III IFN" EXACT [GOC:mah] +is_a: GO:0034342 ! response to type III interferon +is_a: GO:0071345 ! cellular response to cytokine stimulus + +[Term] +id: GO:0071359 +name: cellular response to dsRNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:mah] +synonym: "cellular response to double-stranded RNA" EXACT [GOC:mah] +is_a: GO:0043331 ! response to dsRNA +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0071360 +name: cellular response to exogenous dsRNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:mah] +synonym: "cellular response to exogenous double-stranded RNA" EXACT [GOC:mah] +synonym: "cellular response to viral dsRNA" NARROW [GOC:mah] +is_a: GO:0043330 ! response to exogenous dsRNA +is_a: GO:0071359 ! cellular response to dsRNA + +[Term] +id: GO:0071361 +name: cellular response to ethanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus." [GOC:mah] +is_a: GO:0045471 ! response to ethanol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071362 +name: cellular response to ether +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah] +is_a: GO:0045472 ! response to ether +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071363 +name: cellular response to growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:mah] +is_a: GO:0070848 ! response to growth factor +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071364 +name: cellular response to epidermal growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus." [GOC:mah] +synonym: "cellular response to EGF stimulus" EXACT [GOC:mah] +is_a: GO:0070849 ! response to epidermal growth factor +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus + +[Term] +id: GO:0071365 +name: cellular response to auxin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:mah] +is_a: GO:0009733 ! response to auxin +is_a: GO:0032870 ! cellular response to hormone stimulus + +[Term] +id: GO:0071366 +name: cellular response to indolebutyric acid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [GOC:mah] +synonym: "cellular response to IBA stimulus" EXACT [GOC:mah] +synonym: "cellular response to indole-3-butyric acid stimulus" NARROW [GOC:mah] +is_a: GO:0071365 ! cellular response to auxin stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0080026 ! response to indolebutyric acid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071367 +name: cellular response to brassinosteroid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:mah] +is_a: GO:0009741 ! response to brassinosteroid +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071368 +name: cellular response to cytokinin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:mah] +is_a: GO:0009735 ! response to cytokinin +is_a: GO:0032870 ! cellular response to hormone stimulus + +[Term] +id: GO:0071369 +name: cellular response to ethylene stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:mah] +synonym: "cellular response to ethene stimulus" EXACT [GOC:mah] +is_a: GO:0009723 ! response to ethylene +is_a: GO:0032870 ! cellular response to hormone stimulus + +[Term] +id: GO:0071370 +name: cellular response to gibberellin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:mah] +synonym: "cellular response to gibberellic acid stimulus" NARROW [GOC:mah] +is_a: GO:0009739 ! response to gibberellin +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071371 +name: cellular response to gonadotropin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus." [GOC:mah] +synonym: "cellular response to gonadotrophin stimulus" EXACT [GOC:dph] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0034698 ! response to gonadotropin + +[Term] +id: GO:0071372 +name: cellular response to follicle-stimulating hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] +synonym: "cellular response to follicle stimulating hormone stimulus" EXACT [] +synonym: "cellular response to FSH stimulus" EXACT [] +is_a: GO:0032354 ! response to follicle-stimulating hormone +is_a: GO:0071371 ! cellular response to gonadotropin stimulus + +[Term] +id: GO:0071373 +name: cellular response to luteinizing hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus." [GOC:mah] +is_a: GO:0034699 ! response to luteinizing hormone +is_a: GO:0071371 ! cellular response to gonadotropin stimulus +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0071374 +name: cellular response to parathyroid hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus." [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0071107 ! response to parathyroid hormone + +[Term] +id: GO:0071375 +name: cellular response to peptide hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [GOC:mah] +synonym: "cellular response to polypeptide hormone stimulus" EXACT [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0043434 ! response to peptide hormone +is_a: GO:1901653 ! cellular response to peptide + +[Term] +id: GO:0071376 +name: cellular response to corticotropin-releasing hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [GOC:mah] +synonym: "cellular response to corticoliberin stimulus" EXACT [GOC:mah] +synonym: "cellular response to corticotropin-releasing factor stimulus" EXACT [GOC:mah] +synonym: "cellular response to CRF stimulus" EXACT [GOC:mah] +synonym: "cellular response to CRH stimulus" EXACT [GOC:mah] +is_a: GO:0043435 ! response to corticotropin-releasing hormone +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0071377 +name: cellular response to glucagon stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus." [GOC:mah] +is_a: GO:0033762 ! response to glucagon +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0071378 +name: cellular response to growth hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth." [GOC:mah] +is_a: GO:0060416 ! response to growth hormone +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:0071379 +name: cellular response to prostaglandin stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus." [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0034694 ! response to prostaglandin + +[Term] +id: GO:0071380 +name: cellular response to prostaglandin E stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus." [GOC:mah] +is_a: GO:0034695 ! response to prostaglandin E +is_a: GO:0071379 ! cellular response to prostaglandin stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071381 +name: cellular response to prostaglandin F stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus." [GOC:mah] +is_a: GO:0034696 ! response to prostaglandin F +is_a: GO:0071379 ! cellular response to prostaglandin stimulus + +[Term] +id: GO:0071382 +name: cellular response to prostaglandin I stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus." [GOC:mah] +is_a: GO:0034697 ! response to prostaglandin I +is_a: GO:0071379 ! cellular response to prostaglandin stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071383 +name: cellular response to steroid hormone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus." [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0048545 ! response to steroid hormone +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071384 +name: cellular response to corticosteroid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah] +is_a: GO:0031960 ! response to corticosteroid +is_a: GO:0071383 ! cellular response to steroid hormone stimulus + +[Term] +id: GO:0071385 +name: cellular response to glucocorticoid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [GOC:mah] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:0071384 ! cellular response to corticosteroid stimulus + +[Term] +id: GO:0071386 +name: cellular response to corticosterone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses." [GOC:mah] +is_a: GO:0051412 ! response to corticosterone +is_a: GO:0071385 ! cellular response to glucocorticoid stimulus +is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071387 +name: cellular response to cortisol stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions." [GOC:mah] +synonym: "cellular response to hydrocortisone stimulus" EXACT [GOC:mah] +is_a: GO:0051414 ! response to cortisol +is_a: GO:0071385 ! cellular response to glucocorticoid stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071388 +name: cellular response to cortisone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisone stimulus. Cortisone is a natural glucocorticoid steroid hormone that is metabolically convertible to cortisol. Cortisone is synthesized from cholesterol in the cortex of the adrenal gland under the stimulation of adrenocorticotropin hormone (ACTH). The main physiological effect of cortisone is on carbohydrate metabolism; it can stimulate increased glucose release from the liver, increased liver glycogen synthesis, and decreased utilization of glucose by the tissues." [GOC:mah] +is_a: GO:0051413 ! response to cortisone +is_a: GO:0071385 ! cellular response to glucocorticoid stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071389 +name: cellular response to mineralocorticoid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." [GOC:mah] +is_a: GO:0051385 ! response to mineralocorticoid +is_a: GO:0071384 ! cellular response to corticosteroid stimulus + +[Term] +id: GO:0071390 +name: cellular response to ecdysone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus." [GOC:mah] +is_a: GO:0035075 ! response to ecdysone +is_a: GO:0036315 ! cellular response to sterol +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071391 +name: cellular response to estrogen stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:mah] +synonym: "cellular response to oestrogen stimulus" EXACT [GOC:mah] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0043627 ! response to estrogen + +[Term] +id: GO:0071392 +name: cellular response to estradiol stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah] +synonym: "cellular response to E2 stimulus" EXACT [GOC:mah] +is_a: GO:0032355 ! response to estradiol +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071393 +name: cellular response to progesterone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:mah] +is_a: GO:0032570 ! response to progesterone +is_a: GO:0071383 ! cellular response to steroid hormone stimulus +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071394 +name: cellular response to testosterone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus." [GOC:mah] +is_a: GO:0033574 ! response to testosterone +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071395 +name: cellular response to jasmonic acid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:mah] +is_a: GO:0009753 ! response to jasmonic acid +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0071398 ! cellular response to fatty acid + +[Term] +id: GO:0071396 +name: cellular response to lipid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus." [GOC:mah] +is_a: GO:0033993 ! response to lipid +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071397 +name: cellular response to cholesterol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." [GOC:mah] +is_a: GO:0036315 ! cellular response to sterol +is_a: GO:0070723 ! response to cholesterol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071398 +name: cellular response to fatty acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus." [GOC:mah] +is_a: GO:0070542 ! response to fatty acid +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071399 +name: cellular response to linoleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus." [GOC:mah] +synonym: "cellular response to linoleate" EXACT [GOC:mah] +is_a: GO:0070543 ! response to linoleic acid +is_a: GO:0071398 ! cellular response to fatty acid + +[Term] +id: GO:0071400 +name: cellular response to oleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oleic acid stimulus." [GOC:mah] +synonym: "cellular response to oleate" EXACT [GOC:mah] +is_a: GO:0034201 ! response to oleic acid +is_a: GO:0071398 ! cellular response to fatty acid + +[Term] +id: GO:0071401 +name: cellular response to triglyceride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus." [GOC:mah] +synonym: "cellular response to triacylglyceride" EXACT [GOC:mah] +synonym: "cellular response to triacylglycerol" EXACT [GOC:mah] +is_a: GO:0034014 ! response to triglyceride +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071402 +name: cellular response to lipoprotein particle stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus." [GOC:mah] +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0071403 +name: cellular response to high density lipoprotein particle stimulus +namespace: biological_process +alt_id: GO:0055099 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus." [GOC:mah] +synonym: "cellular response to high-density lipoprotein particle stimulus" EXACT [] +synonym: "response to high density lipoprotein particle" BROAD [] +synonym: "response to high density lipoprotein particle stimulus" BROAD [GOC:dos] +is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus + +[Term] +id: GO:0071404 +name: cellular response to low-density lipoprotein particle stimulus +namespace: biological_process +alt_id: GO:0055098 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus." [GOC:mah] +synonym: "response to low density lipoprotein particle" BROAD [] +synonym: "response to low-density lipoprotein particle" BROAD [GOC:dos] +synonym: "response to low-density lipoprotein particle stimulus" BROAD [] +is_a: GO:0055094 ! response to lipoprotein particle +is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus + +[Term] +id: GO:0071405 +name: cellular response to methanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus." [GOC:mah] +is_a: GO:0033986 ! response to methanol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071406 +name: cellular response to methylmercury +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus." [GOC:mah] +synonym: "cellular response to CH3-Hg+" EXACT [GOC:mah] +synonym: "cellular response to MeHg+" EXACT [GOC:mah] +is_a: GO:0051597 ! response to methylmercury +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071407 +name: cellular response to organic cyclic compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah] +synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071408 +name: cellular response to cycloalkane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [GOC:mah] +is_a: GO:0014071 ! response to cycloalkane +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071409 +name: cellular response to cycloheximide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." [GOC:mah] +synonym: "cellular response to actidione" EXACT [GOC:mah] +is_a: GO:0046898 ! response to cycloheximide +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071410 +name: cellular response to cyclopentenone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [GOC:mah] +is_a: GO:0010583 ! response to cyclopentenone +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071411 +name: cellular response to fluoxetine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [GOC:mah, GOC:pr] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0014076 ! response to fluoxetine +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071412 +name: cellular response to genistein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus." [GOC:mah] +is_a: GO:0033595 ! response to genistein +is_a: GO:0071413 ! cellular response to hydroxyisoflavone + +[Term] +id: GO:0071413 +name: cellular response to hydroxyisoflavone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyisoflavone stimulus." [GOC:mah] +is_a: GO:0033594 ! response to hydroxyisoflavone +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1905546 ! cellular response to phenylpropanoid + +[Term] +id: GO:0071414 +name: cellular response to methotrexate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [GOC:mah] +is_a: GO:0031427 ! response to methotrexate +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071415 +name: cellular response to purine-containing compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [GOC:mah] +synonym: "cellular response to purine" RELATED [] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0071416 +name: cellular response to tropane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [GOC:mah] +is_a: GO:0014073 ! response to tropane +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071407 ! cellular response to organic cyclic compound + +[Term] +id: GO:0071417 +name: cellular response to organonitrogen compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [GOC:mah] +synonym: "cellular response to organic nitrogen" EXACT [GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0071418 +name: cellular response to amine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [GOC:mah] +is_a: GO:0014075 ! response to amine +is_a: GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0071419 +name: cellular response to amphetamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [GOC:mah] +is_a: GO:0001975 ! response to amphetamine +is_a: GO:0071418 ! cellular response to amine stimulus + +[Term] +id: GO:0071420 +name: cellular response to histamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter." [GOC:mah] +synonym: "cellular response to histamine stimulus" EXACT [GOC:mah] +is_a: GO:0034776 ! response to histamine +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0071421 +name: manganese ion transmembrane transport +namespace: biological_process +def: "A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "manganese ion membrane transport" EXACT [] +synonym: "transmembrane manganese transport" EXACT [GOC:mah] +is_a: GO:0006828 ! manganese ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0071422 +name: succinate transmembrane transport +namespace: biological_process +def: "The process in which succinate is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "succinate membrane transport" EXACT [] +synonym: "transmembrane succinate transport" EXACT [GOC:mah] +is_a: GO:0015744 ! succinate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0071423 +name: malate transmembrane transport +namespace: biological_process +def: "A process in which a malate ion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "malate membrane transport" EXACT [] +synonym: "transmembrane malate transport" EXACT [GOC:mah] +is_a: GO:0015743 ! malate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0071424 +name: rRNA (cytosine-N4-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + H+ + S-adenosyl-L-homocysteine." [GOC:imk, PMID:19965768, RHEA:62520] +xref: RHEA:62520 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity + +[Term] +id: GO:0071425 +name: hematopoietic stem cell proliferation +namespace: biological_process +def: "The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop." [CL:0000037, GOC:add, GOC:BHF, GOC:mah, GOC:rl] +synonym: "hemopoietic stem cell proliferation" EXACT [] +is_a: GO:0072089 ! stem cell proliferation +relationship: part_of GO:0030097 ! hemopoiesis + +[Term] +id: GO:0071426 +name: obsolete ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071427 +name: obsolete mRNA-containing ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0006406 + +[Term] +id: GO:0071428 +name: obsolete rRNA-containing ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm." [GOC:mah] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "rRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "rRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "rRNA-containing RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071429 +name: obsolete snRNA-containing ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm." [GOC:mah] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "snRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "snRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "snRNA-containing RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071430 +name: obsolete pre-miRNA-containing ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm." [GOC:mah, GOC:sl] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "pre-microRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "pre-microRNA-containing ribonucleoprotein complex export from nucleus" EXACT [] +synonym: "pre-microRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "pre-microRNA-containing RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071431 +name: obsolete tRNA-containing ribonucleoprotein complex export from nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm." [GOC:mah] +comment: This term has been obsoleted because it represents the transport of a carrier bound to its substrate. +synonym: "tRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] +synonym: "tRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] +synonym: "tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "tRNA-containing RNP export from nucleus" EXACT [GOC:mah] +is_obsolete: true +consider: GO:0051168 + +[Term] +id: GO:0071432 +name: peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion." [GOC:mah] +synonym: "a-factor processing (proteolytic)" NARROW [GOC:vw] +synonym: "alpha-factor maturation" NARROW [GOC:vw] +synonym: "mating-type peptide pheromone maturation involved in conjugation with cellular fusion" EXACT [GOC:mah] +synonym: "peptide mating pheromone formation involved in conjugation with cellular fusion" EXACT [GOC:mah] +synonym: "peptide mating pheromone processing involved in conjugation with cellular fusion" EXACT [GOC:mah] +is_a: GO:0007323 ! peptide pheromone maturation +relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion + +[Term] +id: GO:0071433 +name: cell wall repair +namespace: biological_process +def: "A process of cell wall organization that results in the restoration of the cell wall following damage." [GOC:mah, GOC:vw] +is_a: GO:0071555 ! cell wall organization + +[Term] +id: GO:0071434 +name: cell chemotaxis to angiotensin +namespace: biological_process +def: "The directed movement of a motile cell in response to the presence of angiotensin." [GOC:mah] +synonym: "angiotensin mediated chemotaxis" BROAD [GOC:mah] +synonym: "angiotensin-mediated cell chemotaxis" EXACT [GOC:mah] +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0071437 +name: obsolete invadopodium +namespace: cellular_component +def: "OBSOLETE. A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate." [GOC:mah, PMID:16651416, PMID:19491051, PMID:19931459] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +is_obsolete: true + +[Term] +id: GO:0071438 +name: obsolete invadopodium membrane +namespace: cellular_component +def: "OBSOLETE. The portion of the plasma membrane surrounding an invadopodium." [GOC:mah] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +is_obsolete: true + +[Term] +id: GO:0071439 +name: clathrin complex +namespace: cellular_component +def: "A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface." [GOC:mah, PMID:16493411] +synonym: "clathrin triskelion" EXACT [GOC:mah] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0030118 ! clathrin coat + +[Term] +id: GO:0071440 +name: regulation of histone H3-K14 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] +synonym: "regulation of histone H3 acetylation at K14" EXACT [GOC:mah] +synonym: "regulation of histone H3K14 acetylation" EXACT [GOC:mah] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0044154 ! histone H3-K14 acetylation + +[Term] +id: GO:0071441 +name: negative regulation of histone H3-K14 acetylation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] +synonym: "down regulation of histone H3-K14 acetylation" EXACT [GOC:mah] +synonym: "down-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] +synonym: "downregulation of histone H3-K14 acetylation" EXACT [GOC:mah] +synonym: "inhibition of histone H3-K14 acetylation" NARROW [GOC:mah] +synonym: "negative regulation of histone H3 acetylation at K14" EXACT [GOC:mah] +synonym: "negative regulation of histone H3K14 acetylation" EXACT [GOC:mah] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:0071440 ! regulation of histone H3-K14 acetylation +relationship: negatively_regulates GO:0044154 ! histone H3-K14 acetylation + +[Term] +id: GO:0071442 +name: positive regulation of histone H3-K14 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to histone H3 at position 14 of the histone." [GOC:mah] +synonym: "activation of histone H3-K14 acetylation" NARROW [GOC:mah] +synonym: "positive regulation of histone H3 acetylation at K14" EXACT [GOC:mah] +synonym: "positive regulation of histone H3K14 acetylation" EXACT [GOC:mah] +synonym: "stimulation of histone H3-K14 acetylation" NARROW [GOC:mah] +synonym: "up regulation of histone H3-K14 acetylation" EXACT [GOC:mah] +synonym: "up-regulation of histone H3-K14 acetylation" EXACT [GOC:mah] +synonym: "upregulation of histone H3-K14 acetylation" EXACT [GOC:mah] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:0071440 ! regulation of histone H3-K14 acetylation +relationship: positively_regulates GO:0044154 ! histone H3-K14 acetylation + +[Term] +id: GO:0071443 +name: tDNA binding +namespace: molecular_function +def: "Binding to DNA sequences encoding transfer RNA." [GOC:mah] +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:0071444 +name: cellular response to pheromone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah] +synonym: "cellular pheromone response" EXACT [GOC:mah] +is_a: GO:0019236 ! response to pheromone +is_a: GO:0071310 ! cellular response to organic substance + +[Term] +id: GO:0071445 +name: obsolete cellular response to protein stimulus +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus." [GOC:mah] +comment: This term was made obsolete because more specific terms exist. +synonym: "cellular response to protein stimulus" EXACT [] +is_obsolete: true +consider: GO:0032870 +consider: GO:0034620 +consider: GO:0071218 +consider: GO:0071345 +consider: GO:0071363 + +[Term] +id: GO:0071446 +name: cellular response to salicylic acid stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:mah] +synonym: "cellular response to salicylate stimulus" EXACT [GOC:dph] +is_a: GO:0009751 ! response to salicylic acid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071447 +name: cellular response to hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH." [GOC:mah] +is_a: GO:0033194 ! response to hydroperoxide +is_a: GO:0034599 ! cellular response to oxidative stress +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071448 +name: cellular response to alkyl hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group." [GOC:mah] +is_a: GO:0033195 ! response to alkyl hydroperoxide +is_a: GO:0071447 ! cellular response to hydroperoxide + +[Term] +id: GO:0071449 +name: cellular response to lipid hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:mah] +synonym: "cellular response to LHPO" EXACT [GOC:mah] +is_a: GO:0006982 ! response to lipid hydroperoxide +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071447 ! cellular response to hydroperoxide + +[Term] +id: GO:0071450 +name: cellular response to oxygen radical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah] +is_a: GO:0000305 ! response to oxygen radical +is_a: GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:0071451 +name: cellular response to superoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah] +is_a: GO:0000303 ! response to superoxide +is_a: GO:0071450 ! cellular response to oxygen radical + +[Term] +id: GO:0071452 +name: cellular response to singlet oxygen +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:mah] +is_a: GO:0000304 ! response to singlet oxygen +is_a: GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:0071453 +name: cellular response to oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] +synonym: "cellular response to oxygen" RELATED [GOC:al] +is_a: GO:0070482 ! response to oxygen levels +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071454 +name: cellular response to anoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%." [GOC:mah] +comment: Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'. +synonym: "cellular response to anaerobic conditions" EXACT [GOC:elh] +synonym: "cellular response to anoxic stress" EXACT [GOC:mah] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0034059 ! response to anoxia +is_a: GO:0036294 ! cellular response to decreased oxygen levels + +[Term] +id: GO:0071455 +name: cellular response to hyperoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension." [GOC:mah] +synonym: "cellular response to hyperoxic stress" EXACT [GOC:mah] +synonym: "cellular response to increased oxygen tension" EXACT [GOC:mah] +is_a: GO:0036295 ! cellular response to increased oxygen levels +is_a: GO:0055093 ! response to hyperoxia +is_a: GO:0062197 ! cellular response to chemical stress + +[Term] +id: GO:0071456 +name: cellular response to hypoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] +comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. +synonym: "cellular response to hypoxic stress" EXACT [GOC:mah] +synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah] +is_a: GO:0001666 ! response to hypoxia +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0036294 ! cellular response to decreased oxygen levels + +[Term] +id: GO:0071457 +name: cellular response to ozone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:mah] +is_a: GO:0010193 ! response to ozone +is_a: GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:0071458 +name: integral component of cytoplasmic side of endoplasmic reticulum membrane +namespace: cellular_component +def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to cytosolic leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab] +synonym: "integral to cytosolic side of endoplasmic reticulum membrane" EXACT [] +synonym: "integral to cytosolic side of ER membrane" EXACT [GOC:mah] +synonym: "integral to ER membrane, cytosolic side" EXACT [GOC:vw] +is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane +relationship: part_of GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane + +[Term] +id: GO:0071459 +name: protein localization to chromosome, centromeric region +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah] +synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah] +synonym: "protein localization to centromere" EXACT [GOC:mah] +synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:0071460 +name: cellular response to cell-matrix adhesion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion." [GOC:sl, PMID:11425869] +is_a: GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0071461 +name: cellular response to redox state +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important." [GOC:mah] +synonym: "cellular redox signal response" EXACT [GOC:mah] +is_a: GO:0051775 ! response to redox state + +[Term] +id: GO:0071462 +name: cellular response to water stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] +is_a: GO:0009415 ! response to water +is_a: GO:0071214 ! cellular response to abiotic stimulus +is_a: GO:0071229 ! cellular response to acid chemical +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071463 +name: cellular response to humidity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:mah] +is_a: GO:0009270 ! response to humidity +is_a: GO:0071462 ! cellular response to water stimulus + +[Term] +id: GO:0071464 +name: cellular response to hydrostatic pressure +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it." [GOC:mah] +synonym: "cellular response to biomechanical stress" BROAD [GOC:mah] +synonym: "cellular response to static fluid pressure" EXACT [GOC:mah] +is_a: GO:0051599 ! response to hydrostatic pressure +is_a: GO:0062197 ! cellular response to chemical stress +is_a: GO:0071462 ! cellular response to water stimulus + +[Term] +id: GO:0071465 +name: cellular response to desiccation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] +synonym: "desiccation tolerance" RELATED [GOC:mah] +is_a: GO:0009269 ! response to desiccation +is_a: GO:0042631 ! cellular response to water deprivation + +[Term] +id: GO:0071466 +name: cellular response to xenobiotic stimulus +namespace: biological_process +alt_id: GO:0035690 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GOC:krc, GOC:mah] +subset: goslim_chembl +synonym: "cellular response to drug" RELATED [] +is_a: GO:0009410 ! response to xenobiotic stimulus +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0071467 +name: cellular response to pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, Wikipedia:PH] +is_a: GO:0009268 ! response to pH +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071468 +name: cellular response to acidic pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, Wikipedia:PH] +comment: This term should be used to annotate instances where a cell is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0071229 'cellular response to acid chemical'. +synonym: "cellular response to acidity" BROAD [] +is_a: GO:0010447 ! response to acidic pH +is_a: GO:0071467 ! cellular response to pH + +[Term] +id: GO:0071469 +name: cellular response to alkaline pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:mah, Wikipedia:PH] +synonym: "cellular response to alkalinity" BROAD [] +synonym: "cellular response to basic pH" EXACT [GOC:mah] +is_a: GO:0010446 ! response to alkaline pH +is_a: GO:0071467 ! cellular response to pH + +[Term] +id: GO:0071470 +name: cellular response to osmotic stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] +synonym: "cellular osmotic response" EXACT [GOC:mah] +synonym: "cellular osmotic stress response" EXACT [GOC:mah] +is_a: GO:0006970 ! response to osmotic stress +is_a: GO:0062197 ! cellular response to chemical stress +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071471 +name: cellular response to non-ionic osmotic stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah] +is_a: GO:0010335 ! response to non-ionic osmotic stress +is_a: GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0071472 +name: cellular response to salt stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] +synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah] +synonym: "cellular salinity response" EXACT [GOC:mah] +is_a: GO:0009651 ! response to salt stress +is_a: GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0071473 +name: cellular response to cation stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:mah] +is_a: GO:0043157 ! response to cation stress +is_a: GO:0071472 ! cellular response to salt stress + +[Term] +id: GO:0071474 +name: cellular hyperosmotic response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah] +synonym: "cellular HOG response" EXACT [GOC:mah] +synonym: "cellular hypertonic response" EXACT [GOC:mah] +synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf] +is_a: GO:0006972 ! hyperosmotic response +is_a: GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0071475 +name: cellular hyperosmotic salinity response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] +synonym: "cellular response to hyperosmotic salt stress" EXACT [GOC:mah] +is_a: GO:0042538 ! hyperosmotic salinity response +is_a: GO:0071472 ! cellular response to salt stress +is_a: GO:0071474 ! cellular hyperosmotic response + +[Term] +id: GO:0071476 +name: cellular hypotonic response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah] +synonym: "cellular hypo-osmotic response" EXACT [GOC:mah] +is_a: GO:0006971 ! hypotonic response +is_a: GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0071477 +name: cellular hypotonic salinity response +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] +synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah] +is_a: GO:0042539 ! hypotonic salinity response +is_a: GO:0071472 ! cellular response to salt stress +is_a: GO:0071476 ! cellular hypotonic response + +[Term] +id: GO:0071478 +name: cellular response to radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] +comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. +synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to radiation stimulus" EXACT [GOC:mah] +is_a: GO:0009314 ! response to radiation +is_a: GO:0071214 ! cellular response to abiotic stimulus + +[Term] +id: GO:0071479 +name: cellular response to ionizing radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] +synonym: "cellular response to ionising radiation" EXACT [GOC:mah] +synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah] +is_a: GO:0010212 ! response to ionizing radiation +is_a: GO:0071478 ! cellular response to radiation + +[Term] +id: GO:0071480 +name: cellular response to gamma radiation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] +synonym: "cellular response to gamma ray" RELATED [GOC:mah] +synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah] +is_a: GO:0010332 ! response to gamma radiation +is_a: GO:0071479 ! cellular response to ionizing radiation + +[Term] +id: GO:0071481 +name: cellular response to X-ray +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:mah] +synonym: "cellular response to X-ray radiation stimulus" EXACT [GOC:mah] +is_a: GO:0010165 ! response to X-ray +is_a: GO:0071479 ! cellular response to ionizing radiation + +[Term] +id: GO:0071482 +name: cellular response to light stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] +is_a: GO:0009416 ! response to light stimulus +is_a: GO:0071478 ! cellular response to radiation + +[Term] +id: GO:0071483 +name: cellular response to blue light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:mah] +synonym: "cellular response to blue light stimulus" EXACT [GOC:mah] +is_a: GO:0009637 ! response to blue light +is_a: GO:0071482 ! cellular response to light stimulus + +[Term] +id: GO:0071484 +name: cellular response to light intensity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:mah] +is_a: GO:0009642 ! response to light intensity +is_a: GO:0071482 ! cellular response to light stimulus + +[Term] +id: GO:0071485 +name: cellular response to absence of light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:mah] +synonym: "cellular response to darkness" RELATED [] +is_a: GO:0009646 ! response to absence of light +is_a: GO:0071484 ! cellular response to light intensity + +[Term] +id: GO:0071486 +name: cellular response to high light intensity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:mah] +is_a: GO:0009644 ! response to high light intensity +is_a: GO:0071484 ! cellular response to light intensity + +[Term] +id: GO:0071487 +name: cellular response to low light intensity stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:mah] +is_a: GO:0009645 ! response to low light intensity stimulus +is_a: GO:0071484 ! cellular response to light intensity + +[Term] +id: GO:0071488 +name: cellular response to very low light intensity stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec." [GOC:mah] +is_a: GO:0055122 ! response to very low light intensity stimulus +is_a: GO:0071484 ! cellular response to light intensity + +[Term] +id: GO:0071489 +name: cellular response to red or far red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] +is_a: GO:0009639 ! response to red or far red light +is_a: GO:0071482 ! cellular response to light stimulus + +[Term] +id: GO:0071490 +name: cellular response to far red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] +synonym: "cellular response to far red light stimulus" EXACT [GOC:mah] +is_a: GO:0010218 ! response to far red light +is_a: GO:0071489 ! cellular response to red or far red light + +[Term] +id: GO:0071491 +name: cellular response to red light +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mah] +synonym: "cellular response to red light stimulus" EXACT [GOC:mah] +is_a: GO:0010114 ! response to red light +is_a: GO:0071489 ! cellular response to red or far red light + +[Term] +id: GO:0071492 +name: cellular response to UV-A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm." [GOC:mah] +synonym: "cellular response to UV-A light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UV-A radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVA light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVA radiation stimulus" EXACT [GOC:mah] +is_a: GO:0034644 ! cellular response to UV +is_a: GO:0070141 ! response to UV-A + +[Term] +id: GO:0071493 +name: cellular response to UV-B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:mah] +synonym: "cellular response to medium wave ultraviolet light stimulus" EXACT [GOC:mah] +synonym: "cellular response to medium wave ultraviolet radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to UV-B light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UV-B radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVB light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVB radiation stimulus" EXACT [GOC:mah] +is_a: GO:0010224 ! response to UV-B +is_a: GO:0034644 ! cellular response to UV + +[Term] +id: GO:0071494 +name: cellular response to UV-C +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:mah] +synonym: "cellular response to germicidal ultraviolet light stimulus" EXACT [GOC:mah] +synonym: "cellular response to germicidal ultraviolet radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to shortwave ultraviolet light stimulus" EXACT [GOC:mah] +synonym: "cellular response to shortwave ultraviolet radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to UV-C light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UV-C radiation stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVC light stimulus" EXACT [GOC:mah] +synonym: "cellular response to UVC radiation stimulus" EXACT [GOC:mah] +is_a: GO:0010225 ! response to UV-C +is_a: GO:0034644 ! cellular response to UV + +[Term] +id: GO:0071495 +name: cellular response to endogenous stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0009719 ! response to endogenous stimulus + +[Term] +id: GO:0071496 +name: cellular response to external stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0071497 +name: cellular response to freezing +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah] +synonym: "antifreeze activity" RELATED [GOC:mah] +synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah] +is_a: GO:0050826 ! response to freezing +is_a: GO:0070417 ! cellular response to cold + +[Term] +id: GO:0071498 +name: cellular response to fluid shear stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface." [GOC:mah] +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0034405 ! response to fluid shear stress + +[Term] +id: GO:0071499 +name: cellular response to laminar fluid shear stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers." [GOC:mah] +is_a: GO:0034616 ! response to laminar fluid shear stress +is_a: GO:0071498 ! cellular response to fluid shear stress + +[Term] +id: GO:0071500 +name: cellular response to nitrosative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah] +is_a: GO:0051409 ! response to nitrosative stress +is_a: GO:0062197 ! cellular response to chemical stress + +[Term] +id: GO:0071501 +name: cellular response to sterol depletion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:mah] +synonym: "cellular sterol depletion response" EXACT [GOC:mah] +is_a: GO:0006991 ! response to sterol depletion +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0071502 +name: cellular response to temperature stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:mah] +synonym: "cellular response to thermal stimulus" EXACT [GOC:mah] +is_a: GO:0009266 ! response to temperature stimulus + +[Term] +id: GO:0071503 +name: response to heparin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0071504 +name: cellular response to heparin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heparin stimulus." [GOC:mah, GOC:yaf] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0071503 ! response to heparin +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071505 +name: response to mycophenolic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf] +synonym: "response to mycophenolate" EXACT [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0071506 +name: cellular response to mycophenolic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycophenolic acid stimulus." [GOC:mah, GOC:yaf] +synonym: "cellular response to mycophenolate" EXACT [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071505 ! response to mycophenolic acid +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071507 +name: pheromone response MAPK cascade +namespace: biological_process +def: "A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion." [GOC:mah, GOC:vw, PMID:17604854] +synonym: "conjugation with cellular fusion, MAPKKK cascade" EXACT [GOC:mah] +synonym: "Fus3 signaling cascade" NARROW [PMID:20880736] +synonym: "MAPK cascade involved in conjugation with cellular fusion" EXACT [] +synonym: "MAPK signaling in response to pheromone" RELATED [PMID:20880736] +synonym: "MAPKKK cascade involved in conjugation with cellular fusion" EXACT [GOC:signaling] +synonym: "MAPKKK cascade involved in mating response" RELATED [GOC:mah] +synonym: "pheromone MAPK module" RELATED [PMID:20880736] +is_a: GO:0000165 ! MAPK cascade +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0000747 ! conjugation with cellular fusion +relationship: part_of GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion + +[Term] +id: GO:0071508 +name: obsolete activation of MAPK activity involved in conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAPK activity involved in mating response" RELATED [GOC:mah] +synonym: "conjugation with cellular fusion, activation of MAPK activity" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071509 +name: obsolete activation of MAPKK activity involved in conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAP kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] +synonym: "activation of MAPKK activity involved in mating response" RELATED [GOC:mah] +synonym: "conjugation with cellular fusion, activation of MAP kinase kinase activity" EXACT [GOC:mah] +synonym: "conjugation with cellular fusion, activation of MAPKK activity" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071510 +name: obsolete activation of MAPKKK activity involved in conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of conjugation with cellular fusion." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of MAP kinase kinase kinase activity during conjugation with cellular fusion" EXACT [GOC:mah] +synonym: "activation of MAPKKK activity involved in mating response" RELATED [GOC:mah] +synonym: "conjugation with cellular fusion, activation of MAP kinase kinase kinase activity" EXACT [GOC:mah] +synonym: "conjugation with cellular fusion, activation of MAPKKK activity" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071511 +name: obsolete inactivation of MAPK activity involved in conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. Any process that terminates the activity of the active enzyme MAP kinase in the context of conjugation with cellular fusion." [GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "conjugation with cellular fusion, inactivation of MAPK activity" EXACT [GOC:mah] +synonym: "conjugation with cellular fusion, termination of MAPK activity" EXACT [GOC:mah] +synonym: "inactivation of MAPK activity involved in mating response" RELATED [GOC:mah] +synonym: "termination of MAPK activity during conjugation with cellular fusion" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071512 +name: obsolete MAPK import into nucleus involved in conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of conjugation with cellular fusion." [GOC:mah] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "conjugation with cellular fusion, MAPK import into nucleus" EXACT [GOC:mah] +synonym: "conjugation with cellular fusion, nuclear translocation of MAPK" NARROW [GOC:mah] +synonym: "MAPK import into nucleus involved in mating response" RELATED [GOC:mah] +synonym: "nuclear translocation of MAPK involved in conjugation with cellular fusion" NARROW [GOC:mah] +synonym: "nuclear translocation of MAPK involved in mating response" RELATED [GOC:mah] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:0071513 +name: phosphopantothenoylcysteine decarboxylase complex +namespace: cellular_component +def: "A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces." [GOC:jh, PMID:19915539] +comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071514 +name: genomic imprinting +namespace: biological_process +def: "The establishment of epigenetic modifications (imprints) during gametogenesis, leading to an asymmetry in the heterochromatin between the maternal and paternal alleles, and differential expression of the corresponding alleles. This asymmetry results from the different epigenetic pathways acting in maternal and paternal gametes." [PMID:31896690] +synonym: "DNA imprinting" EXACT [GOC:mah] +synonym: "genetic imprinting" EXACT [] +is_a: GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0071515 +name: mating-type locus imprinting +namespace: biological_process +def: "A genomic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] +synonym: "genetic imprinting at mating-type locus" EXACT [] +synonym: "genomic imprinting at mating-type locus" EXACT [] +synonym: "mating type determination, imprinting" EXACT [GOC:vw] +is_a: GO:0022414 ! reproductive process +is_a: GO:0031507 ! heterochromatin assembly +relationship: part_of GO:0007533 ! mating type switching + +[Term] +id: GO:0071516 +name: establishment of imprinting at mating-type locus +namespace: biological_process +def: "The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:18723894] +synonym: "mating type determination, establishment of imprinting" EXACT [GOC:vw] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0071515 ! mating-type locus imprinting + +[Term] +id: GO:0071517 +name: maintenance of imprinting at mating-type locus +namespace: biological_process +def: "Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] +synonym: "mating type determination, maintenance of imprinting" EXACT [GOC:mah] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0071515 ! mating-type locus imprinting + +[Term] +id: GO:0071518 +name: autoinducer-2 kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP." [GOC:imk, PMID:17274596, PMID:20025244] +synonym: "4,5-dihydroxy-pentane-2,3-dione kinase activity" EXACT [CHEBI:29484, GOC:mah] +xref: MetaCyc:RXN0-5461 +xref: RHEA:15377 +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0071519 +name: actomyosin contractile ring actin filament bundle assembly +namespace: biological_process +def: "A process of actin filament bundle formation that occurs in the context of assembling an actomyosin contractile ring during cytokinesis." [GOC:mah, PMID:19713940] +synonym: "actin filament bundle assembly involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb] +synonym: "actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly" EXACT [] +is_a: GO:0051017 ! actin filament bundle assembly +is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:0071520 +name: actomyosin contractile ring assembly actin filament bundle convergence +namespace: biological_process +def: "A process of actin filament bundle distribution that occurs in the context of assembling an actomyosin contractile ring during cytokinesis, and that results in the compaction of actin filaments into a tight ring." [GOC:mah, PMID:19713940] +synonym: "actin filament bundle convergence involved in actomyosin contractile ring formation" RELATED [GOC:dph, GOC:tb] +synonym: "actin filament bundle convergence involved in cytokinetic actomyosin contractile ring assembly" EXACT [] +is_a: GO:0090426 ! actin filament bundle convergence +is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:0071521 +name: Cdc42 GTPase complex +namespace: cellular_component +def: "A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway." [GOC:mah, GOC:vw, PMID:10567532, PMID:7923372, PMID:8943016] +synonym: "Ras1-Scd1-Scd2-Cdc42-Shk1 complex" EXACT [GOC:vw] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071522 +name: ureidoglycine aminohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3." [MetaCyc:URUR-RXN, PMID:19935661, PMID:20038185] +xref: EC:3.5.3.26 +xref: MetaCyc:URUR-RXN +xref: RHEA:25241 +is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines + +[Term] +id: GO:0071523 +name: obsolete TIR domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TIR domain interaction." [GOC:amm] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +is_obsolete: true + +[Term] +id: GO:0071524 +name: pyrrolysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [GOC:dh, PMID:17204561] +synonym: "monomethylamine methyltransferase cofactor lysine adduct biosynthetic process" EXACT [CHEBI:21860] +synonym: "pyrrolysine anabolism" EXACT [GOC:mah] +synonym: "pyrrolysine biosynthesis" EXACT [GOC:mah] +synonym: "pyrrolysine formation" EXACT [GOC:mah] +synonym: "pyrrolysine synthesis" EXACT [GOC:mah] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0071525 ! pyrrolysine metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0071525 +name: pyrrolysine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine." [GOC:mah, PMID:17204561] +synonym: "monomethylamine methyltransferase cofactor lysine adduct metabolic process" EXACT [CHEBI:21860] +synonym: "pyrrolysine metabolism" EXACT [GOC:mah] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0071526 +name: semaphorin-plexin signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] +synonym: "semaphorin-plexin signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0071527 +name: semaphorin-plexin signaling pathway involved in outflow tract morphogenesis +namespace: biological_process +def: "A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand that contributes to outflow tract morphogenesis." [GOC:BHF, GOC:mah, GOC:vk, PMID:15239959] +synonym: "semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:mah] +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development +is_a: GO:0071526 ! semaphorin-plexin signaling pathway +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:0071528 +name: tRNA re-export from nucleus +namespace: biological_process +def: "The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export." [GOC:mcc, PMID:17475781, PMID:20032305] +synonym: "tRNA reexport from nucleus" EXACT [GOC:mcc] +is_a: GO:0006409 ! tRNA export from nucleus + +[Term] +id: GO:0071529 +name: cementum mineralization +namespace: biological_process +def: "The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum." [GOC:sl, PMID:17043865] +synonym: "cementum formation" RELATED [GOC:mah] +is_a: GO:0034505 ! tooth mineralization + +[Term] +id: GO:0071530 +name: obsolete FHA domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an FHA (forkhead-associated) domain interaction." [GOC:amm, InterPro:IPR000253] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "forkhead-associated domain-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071531 +name: obsolete Rel homology domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a Rel homology domain (RHD) interaction." [GOC:amm, InterPro:IPR011539] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "RHD domain-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071532 +name: ankyrin repeat binding +namespace: molecular_function +def: "Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure." [GOC:mah, InterPro:IPR002110] +synonym: "ANK repeat binding" EXACT [GOC:amm] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071533 +name: obsolete ankyrin repeat-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an ankyrin repeat interaction." [GOC:amm, InterPro:IPR002110] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "ANK repeat-mediated complex assembly" EXACT [GOC:amm] +is_obsolete: true + +[Term] +id: GO:0071534 +name: obsolete zf-TRAF domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a TRAF-type zinc finger (zf-TRAF) domain interaction." [GOC:amm, InterPro:IPR001293] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "TRAF-type zinc finger domain-mediated complex assembly" EXACT [GOC:mah] +synonym: "zinc finger TRAF-type domain-mediated complex assembly" EXACT [GOC:mah] +synonym: "zinc-finger-TRAF domain-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071535 +name: RING-like zinc finger domain binding +namespace: molecular_function +def: "Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain." [GOC:mah, InterPro:IPR014857] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071536 +name: obsolete RING-like zinc finger domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RING-like zinc finger domain interaction." [GOC:amm, InterPro:IPR014857] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "RING-like domain-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071537 +name: obsolete C3HC4-type RING finger domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a C3HC4-type RING finger domain interaction." [GOC:amm, InterPro:IPR018957] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "zinc finger C3HC4 type domain-mediated complex assembly" EXACT [GOC:amm] +is_obsolete: true + +[Term] +id: GO:0071538 +name: obsolete SH2 domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an SH2 domain interaction." [GOC:amm] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +is_obsolete: true + +[Term] +id: GO:0071539 +name: protein localization to centrosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, the centrosome." [GOC:ecd] +synonym: "protein localisation to centrosome" EXACT [GOC:mah] +is_a: GO:1905508 ! protein localization to microtubule organizing center + +[Term] +id: GO:0071540 +name: eukaryotic translation initiation factor 3 complex, eIF3e +namespace: cellular_component +def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." [PMID:15904532, PMID:19061185] +synonym: "eIF3e-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] +is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex + +[Term] +id: GO:0071541 +name: eukaryotic translation initiation factor 3 complex, eIF3m +namespace: cellular_component +def: "An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m." [PMID:15904532, PMID:19061185] +synonym: "eIF3m-containing eukaryotic translation initiation factor 3 complex" EXACT [GOC:mah] +is_a: GO:0005852 ! eukaryotic translation initiation factor 3 complex + +[Term] +id: GO:0071542 +name: dopaminergic neuron differentiation +namespace: biological_process +def: "The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine." [GOC:rph] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0071543 +name: diphosphoinositol polyphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] +synonym: "diphosphoinositol polyphosphate metabolism" EXACT [GOC:mah] +is_a: GO:0043647 ! inositol phosphate metabolic process + +[Term] +id: GO:0071544 +name: diphosphoinositol polyphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached." [GOC:mah, PMID:12387729] +synonym: "diphosphoinositol polyphosphate breakdown" EXACT [GOC:mah] +synonym: "diphosphoinositol polyphosphate catabolism" EXACT [GOC:mah] +synonym: "diphosphoinositol polyphosphate degradation" EXACT [GOC:mah] +is_a: GO:0071543 ! diphosphoinositol polyphosphate metabolic process +is_a: GO:0071545 ! inositol phosphate catabolic process + +[Term] +id: GO:0071545 +name: inositol phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:mah] +comment: See also the biological process term 'inositol phosphate dephosphorylation ; GO:0046855'. +synonym: "inositol phosphate breakdown" EXACT [GOC:mah] +synonym: "inositol phosphate catabolism" EXACT [GOC:mah] +synonym: "inositol phosphate degradation" EXACT [GOC:mah] +synonym: "myo-inositol phosphate catabolic process" NARROW [GOC:mah] +is_a: GO:0043647 ! inositol phosphate metabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:0071546 +name: pi-body +namespace: cellular_component +def: "A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes." [GOC:sp, PMID:20011505] +synonym: "intermitochondrial cement" EXACT [GOC:sp] +is_a: GO:0043186 ! P granule + +[Term] +id: GO:0071547 +name: piP-body +namespace: cellular_component +def: "A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway." [GOC:sp, PMID:20011505] +is_a: GO:0043186 ! P granule + +[Term] +id: GO:0071548 +name: response to dexamethasone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] +synonym: "response to dexamethasone stimulus" EXACT [GOC:dos] +is_a: GO:0051384 ! response to glucocorticoid +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0071549 +name: cellular response to dexamethasone stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus." [GOC:mah, GOC:yaf] +is_a: GO:0071385 ! cellular response to glucocorticoid stimulus +is_a: GO:0071548 ! response to dexamethasone +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071550 +name: death-inducing signaling complex assembly +namespace: biological_process +def: "A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway." [GOC:amm, GOC:mtg_apoptosis, InterPro:IPR000488] +synonym: "DD-mediated complex assembly" EXACT [GOC:mah] +synonym: "death domain-mediated complex assembly" EXACT [] +synonym: "death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [] +synonym: "death-inducing signaling complex formation" EXACT [] +synonym: "death-inducing signalling complex assembly" EXACT [] +synonym: "DISC assembly" EXACT [] +synonym: "DISC formation" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:0071551 +name: RIP homotypic interaction motif binding +namespace: molecular_function +def: "Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases." [GOC:mah, PMID:11734559] +synonym: "RHIM binding" EXACT [GOC:mah] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071552 +name: obsolete RIP homotypic interaction motif-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a RIP homotypic interaction motif (RHIM) interaction." [GOC:amm, PMID:11734559] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "RHIM-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071553 +name: G protein-coupled pyrimidinergic nucleotide receptor activity +namespace: molecular_function +def: "Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:sl, PMID:10736418, PMID:12369950, PMID:15796906] +synonym: "G protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] +synonym: "G-protein coupled pyrimidinergic nucleotide receptor activity" EXACT [] +synonym: "pyrimidinergic nucleotide receptor activity, G protein coupled" EXACT [] +synonym: "pyrimidinergic nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0016502 ! nucleotide receptor activity + +[Term] +id: GO:0071554 +name: cell wall organization or biogenesis +namespace: biological_process +alt_id: GO:0070882 +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] +synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] +synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] +synonym: "cellular cell wall organization or biogenesis" EXACT [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0071555 +name: cell wall organization +namespace: biological_process +alt_id: GO:0007047 +alt_id: GO:0044234 +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] +subset: goslim_candida +subset: goslim_pir +synonym: "cell wall organisation" EXACT [] +synonym: "cell wall organisation in other organism" EXACT [GOC:mah] +synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] +synonym: "cell wall organization at cellular level" EXACT [GOC:mah] +synonym: "cell wall organization in other organism" EXACT [] +synonym: "cellular cell wall organisation" EXACT [] +synonym: "cellular cell wall organization" EXACT [] +is_a: GO:0045229 ! external encapsulating structure organization +is_a: GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0071556 +name: integral component of lumenal side of endoplasmic reticulum membrane +namespace: cellular_component +def: "The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to ER membrane, lumenal side" EXACT [GOC:vw] +synonym: "integral to lumenal leaflet of endoplasmic reticulum membrane" EXACT [GOC:ab] +synonym: "integral to lumenal side of endoplasmic reticulum membrane" NARROW [] +synonym: "integral to lumenal side of ER membrane" EXACT [GOC:mah] +is_a: GO:0030176 ! integral component of endoplasmic reticulum membrane +relationship: part_of GO:0098553 ! lumenal side of endoplasmic reticulum membrane + +[Term] +id: GO:0071557 +name: histone H3-K27 demethylation +namespace: biological_process +def: "The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone." [GOC:sp, PMID:20023638] +synonym: "H3K27 demethylation" RELATED [GOC:mah] +is_a: GO:0070076 ! histone lysine demethylation + +[Term] +id: GO:0071558 +name: histone H3-tri/di-methyl-lysine-27 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [GOC:sp, PMID:20622853] +synonym: "histone demethylase activity (H3-K27 specific)" BROAD [] +synonym: "histone H3K27me2 demethylase activity" RELATED [] +synonym: "histone H3K27me3 demethylase activity" RELATED [] +xref: EC:1.14.11.68 +xref: Reactome:R-HSA-3222593 "KDM6B demethylates H3K27me3 on p16INK4A promoter" +xref: Reactome:R-HSA-5617431 "Retinoic acid activates HOXA1 chromatin" +xref: Reactome:R-HSA-5617887 "HOXC4 chromatin is activated" +xref: RHEA:60224 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032452 ! histone demethylase activity + +[Term] +id: GO:0071559 +name: response to transforming growth factor beta +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:mah] +synonym: "response to TGF-beta stimulus" EXACT [GOC:mah] +synonym: "response to TGFbeta stimulus" EXACT [GOC:mah] +synonym: "response to transforming growth factor beta stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0071560 +name: cellular response to transforming growth factor beta stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus." [GOC:ecd, PMID:15451575] +synonym: "cellular response to TGF-beta stimulus" EXACT [GOC:mah] +synonym: "cellular response to TGFbeta stimulus" EXACT [GOC:mah] +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:0071559 ! response to transforming growth factor beta + +[Term] +id: GO:0071561 +name: nucleus-vacuole junction +namespace: cellular_component +def: "An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156, PMID:16806880] +synonym: "nucleus-vacuole membrane contact site" EXACT [GOC:mah] +synonym: "NV junction" EXACT [GOC:jp, PMID:16709156] +synonym: "NVJ" EXACT [GOC:mah, PMID:16806880] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0071562 +name: nucleus-vacuole junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p." [GOC:jp, PMID:16709156] +synonym: "nucleus-vacuole junction formation" EXACT [GOC:jp] +synonym: "NV junction assembly" EXACT [GOC:jp, PMID:16709156] +synonym: "NV junction formation" EXACT [GOC:jp, PMID:16709156] +synonym: "NVJ assembly" EXACT [GOC:mah, PMID:16806880] +synonym: "NVJ formation" EXACT [GOC:mah, PMID:16806880] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0140056 ! organelle localization by membrane tethering +relationship: part_of GO:0034727 ! piecemeal microautophagy of the nucleus + +[Term] +id: GO:0071563 +name: Myo2p-Vac17p-Vac8p transport complex +namespace: cellular_component +def: "A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p." [GOC:jp, PMID:12594460] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0071564 +name: npBAF complex +namespace: cellular_component +def: "A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells." [GOC:mah, GOC:ss, PMID:17640523] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0071565 +name: nBAF complex +namespace: cellular_component +def: "A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth." [GOC:mah, GOC:ss, PMID:17640523] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0071566 +name: UFM1 activating enzyme activity +namespace: molecular_function +def: "Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:sp, PMID:20018847] +is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity + +[Term] +id: GO:0071567 +name: UFM1 hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates." [GOC:sp, PMID:20018847] +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0071568 +name: UFM1 transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages." [GOC:sp, PMID:20018847] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0071569 +name: protein ufmylation +namespace: biological_process +def: "Covalent attachment of the ubiquitin-like protein UFM1 to another protein." [GOC:vw, PMID:20018847] +is_a: GO:0032446 ! protein modification by small protein conjugation + +[Term] +id: GO:0071570 +name: cement gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed." [GOC:bf] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:0071571 +name: obsolete LRR domain-mediated complex assembly +namespace: biological_process +def: "OBSOLETE. A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by an LRR (leucine-rich repeat) domain interaction." [GOC:amm, InterPro:IPR001611] +comment: This term was obsoleted because it represented a molecular function (binding), not a biological process. The term represented a domain involved in protein-protein interactions, but no necessarily the process of assembling a complex. +synonym: "leucine-rich repeat domain-mediated complex assembly" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0071572 +name: histone H3-K56 deacetylation +namespace: biological_process +def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone." [GOC:mah] +is_a: GO:0070932 ! histone H3 deacetylation + +[Term] +id: GO:0071573 +name: shelterin complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase." [GOC:mah, GOC:vw] +synonym: "Pot1 complex assembly" RELATED [GOC:mah, GOC:vw] +synonym: "Pot1-Tpz1 complex assembly" RELATED [GOC:mah, GOC:vw] +synonym: "shelterin complex formation" RELATED [GOC:mah, GOC:vw] +synonym: "telosome assembly" EXACT [] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0032200 ! telomere organization + +[Term] +id: GO:0071574 +name: protein localization to medial cortex +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah] +synonym: "protein localisation to medial cortex" EXACT [GOC:mah] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:0072741 ! protein localization to cell division site + +[Term] +id: GO:0071575 +name: integral component of external side of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to external leaflet of plasma membrane" EXACT [GOC:ab] +synonym: "integral to external side of plasma membrane" NARROW [] +is_a: GO:0005887 ! integral component of plasma membrane +is_a: GO:0031233 ! intrinsic component of external side of plasma membrane + +[Term] +id: GO:0071576 +name: tetrahydrodictyopterin binding +namespace: molecular_function +def: "Binding to tetrahydrodictyopterin, the pterin 2-amino-6-[(1R,2R)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one." [GOC:mah, GOC:vw] +synonym: "D-threo-tetrahydrobiopterin" EXACT [GOC:mah] +synonym: "DH4 binding" EXACT [GOC:mah] +is_a: GO:0034617 ! tetrahydrobiopterin binding + +[Term] +id: GO:0071577 +name: zinc ion transmembrane transport +namespace: biological_process +def: "A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "zinc II ion transmembrane transport" EXACT [] +synonym: "zinc ion membrane transport" EXACT [] +synonym: "zinc transmembrane transport" EXACT [GOC:mah] +is_a: GO:0006829 ! zinc ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0071578 +name: zinc ion import across plasma membrane +namespace: biological_process +alt_id: GO:0006830 +alt_id: GO:0006831 +alt_id: GO:0044749 +alt_id: GO:0140160 +def: "The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:18637840] +synonym: "high-affinity zinc II ion transmembrane import" NARROW [] +synonym: "high-affinity zinc II ion transport" NARROW [] +synonym: "low-affinity zinc II ion transport" NARROW [] +synonym: "zinc II ion plasma membrane import" EXACT [] +synonym: "zinc II ion transmembrane import" EXACT [] +synonym: "zinc import" EXACT [GOC:mah] +synonym: "zinc ion transmembrane import" RELATED [] +synonym: "zinc uptake" EXACT [GOC:mah] +is_a: GO:0071577 ! zinc ion transmembrane transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:0071579 +name: regulation of zinc ion transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] +is_a: GO:0010959 ! regulation of metal ion transport +relationship: regulates GO:0006829 ! zinc ion transport + +[Term] +id: GO:0071580 +name: regulation of zinc ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] +synonym: "regulation of zinc ion membrane transport" EXACT [] +is_a: GO:0071579 ! regulation of zinc ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0071577 ! zinc ion transmembrane transport + +[Term] +id: GO:0071581 +name: regulation of zinc ion transmembrane import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah] +is_a: GO:0071580 ! regulation of zinc ion transmembrane transport +relationship: regulates GO:0071578 ! zinc ion import across plasma membrane + +[Term] +id: GO:0071582 +name: negative regulation of zinc ion transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:mah] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0071579 ! regulation of zinc ion transport +relationship: negatively_regulates GO:0006829 ! zinc ion transport + +[Term] +id: GO:0071583 +name: negative regulation of zinc ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of zinc ions (Zn2+) from one side of a membrane to the other." [GOC:BHF, GOC:mah] +synonym: "negative regulation of zinc ion membrane transport" EXACT [] +is_a: GO:0071580 ! regulation of zinc ion transmembrane transport +is_a: GO:0071582 ! negative regulation of zinc ion transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0071577 ! zinc ion transmembrane transport + +[Term] +id: GO:0071584 +name: negative regulation of zinc ion transmembrane import +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zinc ion import." [GOC:BHF, GOC:mah] +is_a: GO:0071581 ! regulation of zinc ion transmembrane import +is_a: GO:0071583 ! negative regulation of zinc ion transmembrane transport +relationship: negatively_regulates GO:0071578 ! zinc ion import across plasma membrane + +[Term] +id: GO:0071585 +name: detoxification of cadmium ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion." [GOC:BHF, GOC:kmv, PMID:16741752] +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:1990170 ! stress response to cadmium ion + +[Term] +id: GO:0071586 +name: CAAX-box protein processing +namespace: biological_process +def: "The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis." [GOC:mah] +is_a: GO:0016485 ! protein processing +relationship: part_of GO:0080120 ! CAAX-box protein maturation + +[Term] +id: GO:0071587 +name: CAAX-box protein modification +namespace: biological_process +def: "The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins." [GOC:mah] +is_a: GO:0043687 ! post-translational protein modification +relationship: part_of GO:0080120 ! CAAX-box protein maturation + +[Term] +id: GO:0071588 +name: hydrogen peroxide mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2)." [GOC:mah, PMID:17043891] +synonym: "H2O2 mediated signaling pathway" EXACT [GOC:mah] +synonym: "hydrogen peroxide mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0071589 +name: pyridine nucleoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any pyridine nucleoside, one of a family of organic molecules consisting of a pyridine base covalently bonded to a sugar, usually ribose." [GOC:mah] +synonym: "pyridine nucleoside anabolism" EXACT [GOC:mah] +synonym: "pyridine nucleoside biosynthesis" EXACT [GOC:mah] +synonym: "pyridine nucleoside formation" EXACT [GOC:mah] +synonym: "pyridine nucleoside synthesis" EXACT [GOC:mah] +is_a: GO:0009163 ! nucleoside biosynthetic process +is_a: GO:0070637 ! pyridine nucleoside metabolic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process + +[Term] +id: GO:0071590 +name: nicotinamide riboside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [GOC:mah, PMID:19846558] +synonym: "N-ribosylnicotinamide biosynthetic process" EXACT [CHEBI:15927] +synonym: "nicotinamide riboside anabolism" EXACT [GOC:mah] +synonym: "nicotinamide riboside biosynthesis" EXACT [GOC:mah] +synonym: "nicotinamide riboside formation" EXACT [GOC:mah] +synonym: "nicotinamide riboside synthesis" EXACT [GOC:mah] +is_a: GO:0046495 ! nicotinamide riboside metabolic process +is_a: GO:0071589 ! pyridine nucleoside biosynthetic process + +[Term] +id: GO:0071591 +name: nicotinic acid riboside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [GOC:mah, PMID:19846558] +synonym: "D-ribosylnicotinic acid metabolic process" EXACT [CHEBI:27748] +synonym: "nicotinic acid riboside metabolism" EXACT [GOC:mah] +is_a: GO:0070637 ! pyridine nucleoside metabolic process + +[Term] +id: GO:0071592 +name: nicotinic acid riboside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinic acid riboside, the product of the formation of a glycosidic bond between ribose and nicotinic acid." [GOC:mah, PMID:19846558] +synonym: "D-ribosylnicotinic acid biosynthetic process" EXACT [CHEBI:27748] +synonym: "nicotinic acid riboside anabolism" EXACT [GOC:mah] +synonym: "nicotinic acid riboside biosynthesis" EXACT [GOC:mah] +synonym: "nicotinic acid riboside formation" EXACT [GOC:mah] +synonym: "nicotinic acid riboside synthesis" EXACT [GOC:mah] +is_a: GO:0071589 ! pyridine nucleoside biosynthetic process +is_a: GO:0071591 ! nicotinic acid riboside metabolic process + +[Term] +id: GO:0071593 +name: lymphocyte aggregation +namespace: biological_process +def: "The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules." [GOC:sl] +is_a: GO:0070486 ! leukocyte aggregation + +[Term] +id: GO:0071594 +name: thymocyte aggregation +namespace: biological_process +def: "The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules." [GOC:sl, PMID:1382990] +synonym: "immature T cell aggregation" BROAD [CL:0000893, GOC:sl] +synonym: "immature T-cell aggregation" BROAD [CL:0000893, GOC:mah] +synonym: "immature T-lymphocyte aggregation" EXACT [CL:0000893, GOC:mah] +synonym: "T cell precursor aggregation" EXACT [GOC:sl] +synonym: "thymic lymphocyte aggregation" EXACT [GOC:sl] +is_a: GO:0070489 ! T cell aggregation + +[Term] +id: GO:0071595 +name: Nem1-Spo7 phosphatase complex +namespace: cellular_component +def: "A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p." [GOC:mah, PMID:9822591] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network + +[Term] +id: GO:0071596 +name: ubiquitin-dependent protein catabolic process via the N-end rule pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437] +synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah] +synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah] +synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0071597 +name: cellular birth scar +namespace: cellular_component +def: "Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." [GOC:mcc, PMID:16672383, PMID:7730409] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009277 ! fungal-type cell wall + +[Term] +id: GO:0071598 +name: neuronal ribonucleoprotein granule +namespace: cellular_component +def: "A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli." [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989] +synonym: "neuronal RNA granule" NARROW [] +synonym: "neuronal RNP granule" EXACT [] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule +relationship: part_of GO:0120111 ! neuron projection cytoplasm + +[Term] +id: GO:0071599 +name: otic vesicle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] +is_a: GO:0007423 ! sensory organ development +is_a: GO:0035295 ! tube development +is_a: GO:0048839 ! inner ear development +is_a: GO:0060429 ! epithelium development + +[Term] +id: GO:0071600 +name: otic vesicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:mah] +is_a: GO:0042472 ! inner ear morphogenesis +is_a: GO:0048562 ! embryonic organ morphogenesis +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0071599 ! otic vesicle development + +[Term] +id: GO:0071601 +name: sphere organelle +namespace: cellular_component +def: "A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins." [PMID:7758244, PMID:8349728] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0071602 +name: phytosphingosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol." [GOC:mah] +synonym: "phytosphingosine anabolism" EXACT [GOC:mah] +synonym: "phytosphingosine biosynthesis" EXACT [GOC:mah] +synonym: "phytosphingosine formation" EXACT [GOC:mah] +synonym: "phytosphingosine synthesis" EXACT [GOC:mah] +is_a: GO:0006671 ! phytosphingosine metabolic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0046520 ! sphingoid biosynthetic process + +[Term] +id: GO:0071603 +name: endothelial cell-cell adhesion +namespace: biological_process +def: "The attachment of an endothelial cell to another endothelial cell via adhesion molecules." [GOC:BHF] +is_a: GO:0090136 ! epithelial cell-cell adhesion + +[Term] +id: GO:0071604 +name: transforming growth factor beta production +namespace: biological_process +alt_id: GO:0038044 +def: "The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3." [GOC:add, GOC:rv, PMID:16891311, PMID:2022183] +synonym: "TGF-B production" EXACT [GOC:mah] +synonym: "TGF-beta production" EXACT [PMID:2022183] +synonym: "TGFb production" EXACT [GOC:rv] +synonym: "TGFbeta production" EXACT [PMID:16891311] +synonym: "transforming growth factor-beta production" EXACT [GOC:bf] +synonym: "transforming growth factor-beta secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0071605 +name: monocyte chemotactic protein-1 production +namespace: biological_process +def: "The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL2 production" EXACT [GOC:add, GOC:rv] +synonym: "MCP-1 production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071606 +name: chemokine (C-C motif) ligand 4 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL4 production" EXACT [GOC:add, GOC:rv] +synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] +synonym: "MIP-1b production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071607 +name: macrophage inflammatory protein-1 gamma production +namespace: biological_process +def: "The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL9 production" EXACT [GOC:add, GOC:rv] +synonym: "chemokine (C-C motif) ligand 9 production" EXACT [GOC:add, GOC:rv] +synonym: "MIP-1g production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071608 +name: macrophage inflammatory protein-1 alpha production +namespace: biological_process +def: "The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL3 production" EXACT [GOC:add, GOC:rv] +synonym: "chemokine (C-C motif) ligand 3 production" EXACT [GOC:add, GOC:rv] +synonym: "macrophage inflammatory protein production" BROAD [GOC:add, GOC:rv] +synonym: "MIP-1a production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071609 +name: chemokine (C-C motif) ligand 5 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL5 production" EXACT [GOC:add, GOC:rv] +synonym: "RANTES production" EXACT [GOC:bf] +synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071610 +name: chemokine (C-C motif) ligand 1 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL1 production" EXACT [GOC:add, GOC:rv] +synonym: "T cell activation 3 production" EXACT [GOC:add, GOC:rv] +synonym: "TCA-3 production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071611 +name: granulocyte colony-stimulating factor production +namespace: biological_process +def: "The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "colony stimulating factor 3 (granulocyte) production" EXACT [GOC:add] +synonym: "CSF3 production" EXACT [GOC:add] +synonym: "filgrastim production" EXACT [GOC:add] +synonym: "G-CSF production" EXACT [GOC:add] +synonym: "granulocyte colony stimulating factor production" EXACT [] +synonym: "lenograstim production" EXACT [GOC:add] +synonym: "pluripoietin production" EXACT [GOC:add] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0071612 +name: IP-10 production +namespace: biological_process +def: "The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +subset: gocheck_do_not_annotate +synonym: "chemokine (C-C motif) ligand 10 production" EXACT [GOC:add, GOC:rv] +synonym: "CXCL10 production" EXACT [GOC:add, GOC:rv] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071613 +name: granzyme B production +namespace: biological_process +def: "The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:rv] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response + +[Term] +id: GO:0071614 +name: linoleic acid epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid." [GOC:BHF, PMID:11042099] +synonym: "linoleic acid monooxygenase activity" EXACT [GOC:mah] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0071615 +name: obsolete oxidative deethylation +namespace: biological_process +def: "OBSOLETE. The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0071616 +name: acyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [GOC:cjk] +synonym: "acyl-CoA anabolism" EXACT [GOC:mah] +synonym: "acyl-CoA biosynthesis" EXACT [GOC:mah] +synonym: "acyl-CoA formation" EXACT [GOC:mah] +synonym: "acyl-CoA synthesis" EXACT [GOC:mah] +is_a: GO:0006637 ! acyl-CoA metabolic process +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process +is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process +is_a: GO:0035384 ! thioester biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process + +[Term] +id: GO:0071617 +name: lysophospholipid acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid." [GOC:cjk] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0071618 +name: lysophosphatidylethanolamine acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine." [GOC:cjk] +is_a: GO:0071617 ! lysophospholipid acyltransferase activity + +[Term] +id: GO:0071619 +name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +namespace: biological_process +def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683] +is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain + +[Term] +id: GO:0071620 +name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues +namespace: biological_process +def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683] +is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain + +[Term] +id: GO:0071621 +name: granulocyte chemotaxis +namespace: biological_process +def: "The movement of a granulocyte in response to an external stimulus." [GOC:rph] +is_a: GO:0030595 ! leukocyte chemotaxis +is_a: GO:0097530 ! granulocyte migration + +[Term] +id: GO:0071622 +name: regulation of granulocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +relationship: regulates GO:0071621 ! granulocyte chemotaxis + +[Term] +id: GO:0071623 +name: negative regulation of granulocyte chemotaxis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0071622 ! regulation of granulocyte chemotaxis +relationship: negatively_regulates GO:0071621 ! granulocyte chemotaxis + +[Term] +id: GO:0071624 +name: positive regulation of granulocyte chemotaxis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus." [GOC:mah] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0071622 ! regulation of granulocyte chemotaxis +relationship: positively_regulates GO:0071621 ! granulocyte chemotaxis + +[Term] +id: GO:0071625 +name: vocalization behavior +namespace: biological_process +def: "The behavior in which an organism produces sounds by a mechanism involving its respiratory system." [GOC:mah] +synonym: "vocalisation behaviour" EXACT [GOC:mah] +is_a: GO:0007610 ! behavior + +[Term] +id: GO:0071626 +name: mastication +namespace: biological_process +def: "The process of biting and mashing food with the teeth prior to swallowing." [GOC:gvg] +synonym: "chewing" EXACT [GOC:mah] +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0071627 +name: integral component of fungal-type vacuolar membrane +namespace: cellular_component +def: "The component of the fungal-type vacuole membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] +synonym: "integral to fungal-type vacuolar membrane" NARROW [] +is_a: GO:0031166 ! integral component of vacuolar membrane +is_a: GO:0071628 ! intrinsic component of fungal-type vacuolar membrane + +[Term] +id: GO:0071628 +name: intrinsic component of fungal-type vacuolar membrane +namespace: cellular_component +def: "The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +is_a: GO:0031310 ! intrinsic component of vacuolar membrane +relationship: part_of GO:0000329 ! fungal-type vacuole membrane + +[Term] +id: GO:0071629 +name: cytoplasm protein quality control by the ubiquitin-proteasome system +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635] +comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. +synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] +synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] +synonym: "cytoplasm-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] +synonym: "ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome" EXACT [] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process +is_a: GO:0140455 ! cytoplasm protein quality control +relationship: part_of GO:0071218 ! cellular response to misfolded protein + +[Term] +id: GO:0071630 +name: nuclear protein quality control by the ubiquitin-proteasome system +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation." [GOC:mah, GOC:rb, PMID:20080635, PMID:21211726, PMID:21324894] +comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. +synonym: "nucleus-associated proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:mah] +synonym: "nucleus-associated proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:mah] +synonym: "nucleus-associated proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:mah] +synonym: "ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome" EXACT [] +is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process +relationship: part_of GO:0071218 ! cellular response to misfolded protein + +[Term] +id: GO:0071631 +name: mating pheromone secretion involved in positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that positively regulates a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] +synonym: "mating-type pheromone secretion involved in conjugation with cellular fusion" EXACT [GOC:vw] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion +is_a: GO:0071834 ! mating pheromone secretion + +[Term] +id: GO:0071632 +name: optomotor response +namespace: biological_process +def: "Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish." [GOC:dos, PMID:12726833, PMID:2469195] +xref: Wikipedia:Optomotor_response +is_a: GO:0007634 ! optokinetic behavior + +[Term] +id: GO:0071633 +name: dihydroceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine." [GOC:mah, PMID:10900202] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds +is_a: GO:0017040 ! N-acylsphingosine amidohydrolase activity + +[Term] +id: GO:0071634 +name: regulation of transforming growth factor beta production +namespace: biological_process +alt_id: GO:2001201 +def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] +synonym: "regulation of TGF-B production" EXACT [GOC:mah] +synonym: "regulation of TGF-beta production" EXACT [GOC:mah] +synonym: "regulation of TGFB production" EXACT [GOC:mah] +synonym: "regulation of TGFbeta production" EXACT [GOC:obol] +synonym: "regulation of transforming growth factor-beta production" EXACT [GOC:bf] +synonym: "regulation of transforming growth factor-beta secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0071635 +name: negative regulation of transforming growth factor beta production +namespace: biological_process +alt_id: GO:2001202 +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] +synonym: "negative regulation of TGF-B production" EXACT [GOC:mah] +synonym: "negative regulation of TGF-beta production" EXACT [GOC:mah] +synonym: "negative regulation of TGFB production" EXACT [GOC:mah] +synonym: "negative regulation of TGFbeta production" EXACT [GOC:obol] +synonym: "negative regulation of transforming growth factor-beta production" EXACT [GOC:bf] +synonym: "negative regulation of transforming growth factor-beta secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: negatively_regulates GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0071636 +name: positive regulation of transforming growth factor beta production +namespace: biological_process +alt_id: GO:2001203 +def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta." [GOC:mah] +synonym: "positive regulation of TGF-B production" EXACT [GOC:mah] +synonym: "positive regulation of TGF-beta production" EXACT [GOC:mah] +synonym: "positive regulation of TGFB production" EXACT [GOC:mah] +synonym: "positive regulation of TGFbeta production" EXACT [GOC:obol] +synonym: "positive regulation of transforming growth factor-beta production" EXACT [GOC:bf] +synonym: "positive regulation of transforming growth factor-beta secretion" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: positively_regulates GO:0071604 ! transforming growth factor beta production + +[Term] +id: GO:0071637 +name: regulation of monocyte chemotactic protein-1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] +synonym: "regulation of CCL2 production" EXACT [GOC:mah] +synonym: "regulation of MCP-1 production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071605 ! monocyte chemotactic protein-1 production + +[Term] +id: GO:0071638 +name: negative regulation of monocyte chemotactic protein-1 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] +synonym: "negative regulation of CCL2 production" EXACT [GOC:mah] +synonym: "negative regulation of MCP-1 production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production +relationship: negatively_regulates GO:0071605 ! monocyte chemotactic protein-1 production + +[Term] +id: GO:0071639 +name: positive regulation of monocyte chemotactic protein-1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1." [GOC:mah] +synonym: "positive regulation of CCL2 production" EXACT [GOC:mah] +synonym: "positive regulation of MCP-1 production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071637 ! regulation of monocyte chemotactic protein-1 production +relationship: positively_regulates GO:0071605 ! monocyte chemotactic protein-1 production + +[Term] +id: GO:0071640 +name: regulation of macrophage inflammatory protein 1 alpha production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] +synonym: "regulation of CCL3 production" EXACT [GOC:mah] +synonym: "regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] +synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "regulation of MIP-1a production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production + +[Term] +id: GO:0071641 +name: negative regulation of macrophage inflammatory protein 1 alpha production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] +synonym: "negative regulation of CCL3 production" EXACT [GOC:mah] +synonym: "negative regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] +synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "negative regulation of MIP-1a production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production +relationship: negatively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production + +[Term] +id: GO:0071642 +name: positive regulation of macrophage inflammatory protein 1 alpha production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha." [GOC:mah] +synonym: "positive regulation of CCL3 production" EXACT [GOC:mah] +synonym: "positive regulation of chemokine (C-C motif) ligand 3 production" EXACT [GOC:mah] +synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "positive regulation of MIP-1a production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071640 ! regulation of macrophage inflammatory protein 1 alpha production +relationship: positively_regulates GO:0071608 ! macrophage inflammatory protein-1 alpha production + +[Term] +id: GO:0071643 +name: regulation of chemokine (C-C motif) ligand 4 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] +synonym: "regulation of CCL4 production" EXACT [GOC:mah] +synonym: "regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "regulation of MIP-1b production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production + +[Term] +id: GO:0071644 +name: negative regulation of chemokine (C-C motif) ligand 4 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] +synonym: "negative regulation of CCL4 production" EXACT [GOC:mah] +synonym: "negative regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "negative regulation of MIP-1b production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production +relationship: negatively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production + +[Term] +id: GO:0071645 +name: positive regulation of chemokine (C-C motif) ligand 4 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 4." [GOC:mah] +synonym: "positive regulation of CCL4 production" EXACT [GOC:mah] +synonym: "positive regulation of macrophage inflammatory protein production" BROAD [GOC:mah] +synonym: "positive regulation of MIP-1b production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071643 ! regulation of chemokine (C-C motif) ligand 4 production +relationship: positively_regulates GO:0071606 ! chemokine (C-C motif) ligand 4 production + +[Term] +id: GO:0071646 +name: regulation of macrophage inflammatory protein-1 gamma production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] +synonym: "regulation of CCL9 production" EXACT [GOC:mah] +synonym: "regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] +synonym: "regulation of MIP-1g production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production + +[Term] +id: GO:0071647 +name: negative regulation of macrophage inflammatory protein-1 gamma production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] +synonym: "negative regulation of CCL9 production" EXACT [GOC:mah] +synonym: "negative regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] +synonym: "negative regulation of MIP-1g production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production +relationship: negatively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production + +[Term] +id: GO:0071648 +name: positive regulation of macrophage inflammatory protein-1 gamma production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of macrophage inflammatory protein-1 gamma." [GOC:mah] +synonym: "positive regulation of CCL9 production" EXACT [GOC:mah] +synonym: "positive regulation of chemokine (C-C motif) ligand 9 production" EXACT [GOC:mah] +synonym: "positive regulation of MIP-1g production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071646 ! regulation of macrophage inflammatory protein-1 gamma production +relationship: positively_regulates GO:0071607 ! macrophage inflammatory protein-1 gamma production + +[Term] +id: GO:0071649 +name: regulation of chemokine (C-C motif) ligand 5 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] +synonym: "regulation of CCL5 production" EXACT [GOC:mah] +synonym: "regulation of RANTES production" EXACT [GOC:bf] +synonym: "regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production + +[Term] +id: GO:0071650 +name: negative regulation of chemokine (C-C motif) ligand 5 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] +synonym: "negative regulation of CCL5 production" EXACT [GOC:mah] +synonym: "negative regulation of RANTES production" EXACT [GOC:bf] +synonym: "negative regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production +relationship: negatively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production + +[Term] +id: GO:0071651 +name: positive regulation of chemokine (C-C motif) ligand 5 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 5." [GOC:mah] +synonym: "positive regulation of CCL5 production" EXACT [GOC:mah] +synonym: "positive regulation of RANTES production" EXACT [GOC:bf] +synonym: "positive regulation of Regulated upon Activation, Normal T-cell Expressed, and Secreted production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071649 ! regulation of chemokine (C-C motif) ligand 5 production +relationship: positively_regulates GO:0071609 ! chemokine (C-C motif) ligand 5 production + +[Term] +id: GO:0071652 +name: regulation of chemokine (C-C motif) ligand 1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] +synonym: "regulation of CCL1 production" EXACT [GOC:mah] +synonym: "regulation of T cell activation 3 production" EXACT [GOC:mah] +synonym: "regulation of TCA-3 production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production + +[Term] +id: GO:0071653 +name: negative regulation of chemokine (C-C motif) ligand 1 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] +synonym: "negative regulation of CCL1 production" EXACT [GOC:mah] +synonym: "negative regulation of T cell activation 3 production" EXACT [GOC:mah] +synonym: "negative regulation of TCA-3 production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production +relationship: negatively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production + +[Term] +id: GO:0071654 +name: positive regulation of chemokine (C-C motif) ligand 1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 1." [GOC:mah] +synonym: "positive regulation of CCL1 production" EXACT [GOC:mah] +synonym: "positive regulation of T cell activation 3 production" EXACT [GOC:mah] +synonym: "positive regulation of TCA-3 production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071652 ! regulation of chemokine (C-C motif) ligand 1 production +relationship: positively_regulates GO:0071610 ! chemokine (C-C motif) ligand 1 production + +[Term] +id: GO:0071655 +name: regulation of granulocyte colony-stimulating factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] +synonym: "regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] +synonym: "regulation of CSF3 production" EXACT [GOC:mah] +synonym: "regulation of filgrastim production" EXACT [GOC:mah] +synonym: "regulation of G-CSF production" EXACT [GOC:mah] +synonym: "regulation of granulocyte colony stimulating factor production" EXACT [] +synonym: "regulation of lenograstim production" EXACT [GOC:mah] +synonym: "regulation of pluripoietin production" EXACT [GOC:mah] +is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production +relationship: regulates GO:0071611 ! granulocyte colony-stimulating factor production + +[Term] +id: GO:0071656 +name: negative regulation of granulocyte colony-stimulating factor production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor." [GOC:mah] +synonym: "negative regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] +synonym: "negative regulation of CSF3 production" EXACT [GOC:mah] +synonym: "negative regulation of filgrastim production" EXACT [GOC:mah] +synonym: "negative regulation of G-CSF production" EXACT [GOC:mah] +synonym: "negative regulation of granulocyte colony stimulating factor production" EXACT [] +synonym: "negative regulation of lenograstim production" EXACT [GOC:mah] +synonym: "negative regulation of pluripoietin production" EXACT [GOC:mah] +is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production +is_a: GO:1901257 ! negative regulation of macrophage colony-stimulating factor production +relationship: negatively_regulates GO:0071611 ! granulocyte colony-stimulating factor production + +[Term] +id: GO:0071657 +name: positive regulation of granulocyte colony-stimulating factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor." [GOC:mah] +synonym: "positive regulation of colony stimulating factor 3 (granulocyte) production" EXACT [GOC:mah] +synonym: "positive regulation of CSF3 production" EXACT [GOC:mah] +synonym: "positive regulation of filgrastim production" EXACT [GOC:mah] +synonym: "positive regulation of G-CSF production" EXACT [GOC:mah] +synonym: "positive regulation of granulocyte colony stimulating factor production" EXACT [] +synonym: "positive regulation of lenograstim production" EXACT [GOC:mah] +synonym: "positive regulation of pluripoietin production" EXACT [GOC:mah] +is_a: GO:0071655 ! regulation of granulocyte colony-stimulating factor production +is_a: GO:1901258 ! positive regulation of macrophage colony-stimulating factor production +relationship: positively_regulates GO:0071611 ! granulocyte colony-stimulating factor production + +[Term] +id: GO:0071658 +name: regulation of IP-10 production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of IP-10." [GOC:mah] +synonym: "regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] +synonym: "regulation of CXCL10 production" EXACT [GOC:mah] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0071612 ! IP-10 production + +[Term] +id: GO:0071659 +name: negative regulation of IP-10 production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of IP-10." [GOC:mah] +synonym: "negative regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] +synonym: "negative regulation of CXCL10 production" EXACT [GOC:mah] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:0071658 ! regulation of IP-10 production +relationship: negatively_regulates GO:0071612 ! IP-10 production + +[Term] +id: GO:0071660 +name: positive regulation of IP-10 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of IP-10." [GOC:mah] +synonym: "positive regulation of chemokine (C-C motif) ligand 10 production" EXACT [GOC:mah] +synonym: "positive regulation of CXCL10 production" EXACT [GOC:mah] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:0071658 ! regulation of IP-10 production +relationship: positively_regulates GO:0071612 ! IP-10 production + +[Term] +id: GO:0071661 +name: regulation of granzyme B production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of granzyme B." [GOC:mah] +is_a: GO:0001817 ! regulation of cytokine production +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0071613 ! granzyme B production + +[Term] +id: GO:0071662 +name: negative regulation of granzyme B production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granzyme B." [GOC:mah] +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:0071661 ! regulation of granzyme B production +relationship: negatively_regulates GO:0071613 ! granzyme B production + +[Term] +id: GO:0071663 +name: positive regulation of granzyme B production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of production of granzyme B." [GOC:mah] +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:0071661 ! regulation of granzyme B production +relationship: positively_regulates GO:0071613 ! granzyme B production + +[Term] +id: GO:0071664 +name: catenin-TCF7L2 complex +namespace: cellular_component +def: "A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:rl, GOC:vk, PMID:14661054] +synonym: "catenin-TCF4 complex" EXACT [GOC:mah] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071665 +name: gamma-catenin-TCF7L2 complex +namespace: cellular_component +def: "A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." [GOC:BHF, GOC:vk, PMID:14661054] +synonym: "gamma-catenin-TCF4 complex" EXACT [GOC:mah] +synonym: "plakoglobin-TCF4 complex" EXACT [PMID:14661054] +is_a: GO:0071664 ! catenin-TCF7L2 complex + +[Term] +id: GO:0071666 +name: Slit-Robo signaling complex +namespace: cellular_component +def: "A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate." [GOC:sart, PMID:17062560, PMID:18359766] +synonym: "Slit-Robo signalling complex" EXACT [GOC:mah] +is_a: GO:0032992 ! protein-carbohydrate complex + +[Term] +id: GO:0071667 +name: DNA/RNA hybrid binding +namespace: molecular_function +def: "Binding to a RNA/DNA hybrid." [GOC:ecd] +synonym: "RNA/DNA hybrid binding" EXACT [GOC:ecd] +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0071668 +name: plant-type cell wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall." [GOC:mah] +synonym: "plant cell wall assembly" NARROW [] +is_a: GO:0009664 ! plant-type cell wall organization +is_a: GO:0070726 ! cell wall assembly +relationship: part_of GO:0009832 ! plant-type cell wall biogenesis + +[Term] +id: GO:0071669 +name: plant-type cell wall organization or biogenesis +namespace: biological_process +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [GOC:ecd, GOC:mah] +synonym: "plant-type cell wall organisation or biogenesis" EXACT [GOC:mah] +synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0071670 +name: smooth muscle cell chemotaxis +namespace: biological_process +def: "The directed movement of a smooth muscle cell in response to an external stimulus." [GOC:mah] +is_a: GO:0014909 ! smooth muscle cell migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:0071671 +name: regulation of smooth muscle cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0071670 ! smooth muscle cell chemotaxis + +[Term] +id: GO:0071672 +name: negative regulation of smooth muscle cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] +synonym: "down regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +synonym: "down-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +synonym: "downregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +synonym: "inhibition of smooth muscle cell chemotaxis" NARROW [GOC:mah] +is_a: GO:0014912 ! negative regulation of smooth muscle cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis +relationship: negatively_regulates GO:0071670 ! smooth muscle cell chemotaxis + +[Term] +id: GO:0071673 +name: positive regulation of smooth muscle cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis." [GOC:mah] +synonym: "activation of smooth muscle cell chemotaxis" NARROW [GOC:mah] +synonym: "stimulation of smooth muscle cell chemotaxis" NARROW [GOC:mah] +synonym: "up regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +synonym: "up-regulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +synonym: "upregulation of smooth muscle cell chemotaxis" EXACT [GOC:mah] +is_a: GO:0014911 ! positive regulation of smooth muscle cell migration +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:0071671 ! regulation of smooth muscle cell chemotaxis +relationship: positively_regulates GO:0071670 ! smooth muscle cell chemotaxis + +[Term] +id: GO:0071674 +name: mononuclear cell migration +namespace: biological_process +def: "The movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] +is_a: GO:0050900 ! leukocyte migration + +[Term] +id: GO:0071675 +name: regulation of mononuclear cell migration +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:0071674 ! mononuclear cell migration + +[Term] +id: GO:0071676 +name: negative regulation of mononuclear cell migration +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] +synonym: "down regulation of mononuclear cell migration" EXACT [GOC:mah] +synonym: "down-regulation of mononuclear cell migration" EXACT [GOC:mah] +synonym: "downregulation of mononuclear cell migration" EXACT [GOC:mah] +synonym: "inhibition of mononuclear cell migration" NARROW [GOC:mah] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: negatively_regulates GO:0071674 ! mononuclear cell migration + +[Term] +id: GO:0071677 +name: positive regulation of mononuclear cell migration +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." [GOC:mah] +synonym: "activation of mononuclear cell migration" NARROW [GOC:mah] +synonym: "stimulation of mononuclear cell migration" NARROW [GOC:mah] +synonym: "up regulation of mononuclear cell migration" EXACT [GOC:mah] +synonym: "up-regulation of mononuclear cell migration" EXACT [GOC:mah] +synonym: "upregulation of mononuclear cell migration" EXACT [GOC:mah] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: positively_regulates GO:0071674 ! mononuclear cell migration + +[Term] +id: GO:0071678 +name: olfactory bulb axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] +synonym: "olfactory bulb axon pathfinding" EXACT [GOC:vk] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0071679 +name: commissural neuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:mah] +synonym: "commissural neuron axon pathfinding" EXACT [GOC:vk] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0071680 +name: response to indole-3-methanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] +synonym: "response to indole-3-carbinol" EXACT [CHEBI:24814] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0071681 +name: cellular response to indole-3-methanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indole-3-methanol stimulus." [GOC:mah, GOC:yaf] +synonym: "cellular response to indole-3-carbinol" EXACT [CHEBI:24814] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0071680 ! response to indole-3-methanol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0071682 +name: endocytic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of an endocytic vesicle." [GOC:pde] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0030139 ! endocytic vesicle + +[Term] +id: GO:0071683 +name: sensory dendrite +namespace: cellular_component +def: "A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron." [GOC:dos, GOC:kmv, GOC:mah] +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0071684 +name: organism emergence from protective structure +namespace: biological_process +def: "The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case." [GOC:mah] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0071685 +name: NADH dehydrogenase complex (plastoquinone) +namespace: cellular_component +def: "An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids." [DOI:10.1078/0176-1617-00593, GOC:mah] +is_a: GO:0010598 ! NAD(P)H dehydrogenase complex (plastoquinone) +is_a: GO:0030964 ! NADH dehydrogenase complex +relationship: part_of GO:0031976 ! plastid thylakoid + +[Term] +id: GO:0071686 +name: obsolete horsetail nucleus +namespace: cellular_component +def: "OBSOLETE. The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757] +comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions. +is_obsolete: true + +[Term] +id: GO:0071687 +name: obsolete horsetail nucleus leading edge +namespace: cellular_component +def: "OBSOLETE. The part of the horsetail nucleus where telomeres cluster under the SPB and that leads horsetail movement. The horsetail nucleus is the elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:mah, GOC:vw, PMID:15030757] +comment: This term was made obsolete at the request of PomBase as the concept can be expressed by annotating to a less granular term and using annotation extensions. +is_obsolete: true + +[Term] +id: GO:0071688 +name: striated muscle myosin thick filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle." [GOC:mah] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0031034 ! myosin filament assembly +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0071689 +name: muscle thin filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle." [GOC:mah] +is_a: GO:0007015 ! actin filament organization +relationship: part_of GO:0030239 ! myofibril assembly + +[Term] +id: GO:0071690 +name: cardiac muscle myosin thick filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle." [GOC:mah] +is_a: GO:0071688 ! striated muscle myosin thick filament assembly +relationship: part_of GO:0055003 ! cardiac myofibril assembly + +[Term] +id: GO:0071691 +name: cardiac muscle thin filament assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle." [GOC:mah] +is_a: GO:0007015 ! actin filament organization +relationship: part_of GO:0055003 ! cardiac myofibril assembly + +[Term] +id: GO:0071692 +name: protein localization to extracellular region +namespace: biological_process +def: "Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location." [GOC:mah] +synonym: "protein localisation in extracellular region" EXACT [GOC:mah] +synonym: "protein localization in extracellular region" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0071693 +name: protein transport within extracellular region +namespace: biological_process +def: "The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0015031 ! protein transport +is_a: GO:0035592 ! establishment of protein localization to extracellular region + +[Term] +id: GO:0071694 +name: maintenance of protein location in extracellular region +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0045185 ! maintenance of protein location +relationship: part_of GO:0071692 ! protein localization to extracellular region + +[Term] +id: GO:0071695 +name: anatomical structure maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] +is_a: GO:0021700 ! developmental maturation +relationship: part_of GO:0048856 ! anatomical structure development + +[Term] +id: GO:0071696 +name: ectodermal placode development +namespace: biological_process +def: "The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0071697 +name: ectodermal placode morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm." [GOC:mah] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0071696 ! ectodermal placode development + +[Term] +id: GO:0071698 +name: olfactory placode development +namespace: biological_process +def: "The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] +is_a: GO:0071696 ! ectodermal placode development + +[Term] +id: GO:0071699 +name: olfactory placode morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] +is_a: GO:0048598 ! embryonic morphogenesis +is_a: GO:0071697 ! ectodermal placode morphogenesis +relationship: part_of GO:0071698 ! olfactory placode development + +[Term] +id: GO:0071700 +name: olfactory placode maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:mah] +is_a: GO:0071695 ! anatomical structure maturation +relationship: part_of GO:0071698 ! olfactory placode development + +[Term] +id: GO:0071701 +name: regulation of MAPK export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a MAP kinase from the nucleus to the cytoplasm." [GOC:dgf] +synonym: "regulation of cytoplasmic translocation of MAP kinase" EXACT [GOC:mah] +synonym: "regulation of cytoplasmic translocation of mitogen-activated protein kinase" EXACT [GOC:mah] +synonym: "regulation of MAPK export from cell nucleus" EXACT [GOC:mah] +synonym: "regulation of MAPK export out of nucleus" EXACT [GOC:mah] +synonym: "regulation of MAPK transport from nucleus to cytoplasm" EXACT [GOC:mah] +synonym: "regulation of MAPK-nucleus export" EXACT [GOC:mah] +is_a: GO:0046825 ! regulation of protein export from nucleus +relationship: regulates GO:0045204 ! MAPK export from nucleus + +[Term] +id: GO:0071702 +name: organic substance transport +namespace: biological_process +def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [GOC:mah] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0071703 +name: detection of organic substance +namespace: biological_process +def: "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0071704 +name: organic substance metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [GOC:mah] +synonym: "organic molecular entity metabolic process" EXACT [] +synonym: "organic molecular entity metabolism" EXACT [] +synonym: "organic substance metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:0071705 +name: nitrogen compound transport +namespace: biological_process +def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0071706 +name: tumor necrosis factor superfamily cytokine production +namespace: biological_process +def: "The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "TNF superfamily production" RELATED [GOC:rv] +synonym: "TNFSF cytokine production" EXACT [GOC:add] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0071707 +name: immunoglobulin heavy chain V-D-J recombination +namespace: biological_process +def: "The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] +synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] +synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] +synonym: "immunoglobulin V-D-J joining" EXACT [GOC:add] +is_a: GO:0033152 ! immunoglobulin V(D)J recombination + +[Term] +id: GO:0071708 +name: immunoglobulin light chain V-J recombination +namespace: biological_process +def: "The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS)." [GOC:add, ISBN:0781735149] +synonym: "immunoglobulin V(D)J joining" BROAD [GOC:add] +synonym: "immunoglobulin V(D)J recombination" BROAD [GOC:add] +synonym: "immunoglobulin V-J joining" EXACT [GOC:add] +is_a: GO:0033152 ! immunoglobulin V(D)J recombination + +[Term] +id: GO:0071709 +name: membrane assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0044091 ! membrane biogenesis + +[Term] +id: GO:0071710 +name: membrane macromolecule biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell." [GOC:mah] +synonym: "membrane macromolecule anabolism" EXACT [GOC:mah] +synonym: "membrane macromolecule biosynthesis" EXACT [GOC:mah] +synonym: "membrane macromolecule formation" EXACT [GOC:mah] +synonym: "membrane macromolecule synthesis" EXACT [GOC:mah] +is_a: GO:0070589 ! cellular component macromolecule biosynthetic process +relationship: part_of GO:0044091 ! membrane biogenesis + +[Term] +id: GO:0071711 +name: basement membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane." [GOC:mah] +comment: Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. +synonym: "basement membrane organisation" EXACT [GOC:mah] +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0071712 +name: ER-associated misfolded protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation." [GOC:mah, GOC:vw, PMID:14607247, PMID:19520858] +comment: See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. +synonym: "endoplasmic reticulum-associated misfolded protein catabolic process" EXACT [GOC:mah] +synonym: "endoplasmic reticulum-associated misfolded protein catabolism" EXACT [GOC:mah] +synonym: "ER-associated misfolded protein breakdown" EXACT [GOC:mah] +synonym: "ER-associated misfolded protein catabolism" EXACT [GOC:mah] +synonym: "ER-associated misfolded protein degradation" EXACT [GOC:mah] +synonym: "proteasomal protein catabolism of misfolded ER proteins" EXACT [GOC:bf] +is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins +is_a: GO:0036503 ! ERAD pathway +relationship: part_of GO:0071218 ! cellular response to misfolded protein + +[Term] +id: GO:0071713 +name: para-aminobenzoyl-glutamate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate." [GOC:imk, PMID:20190044] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0071714 +name: icosanoid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of icosanoids from one side of a membrane to the other." [GOC:sl] +synonym: "eicosanoid transmembrane transporter activity" EXACT [GOC:sl] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0071715 +name: icosanoid transport +namespace: biological_process +def: "The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [GOC:mah] +synonym: "eicosanoid transport" EXACT [GOC:sl] +is_a: GO:0046942 ! carboxylic acid transport + +[Term] +id: GO:0071716 +name: leukotriene transport +namespace: biological_process +def: "The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [GOC:mah] +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:0071717 +name: thromboxane transport +namespace: biological_process +def: "The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [GOC:mah] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:0071718 +name: sodium-independent icosanoid transport +namespace: biological_process +def: "The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." [GOC:mah, GOC:sl] +synonym: "sodium-independent eicosanoid transport" EXACT [GOC:sl] +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:0071719 +name: sodium-independent leukotriene transport +namespace: biological_process +def: "The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups." [GOC:mah] +is_a: GO:0071716 ! leukotriene transport +is_a: GO:0071718 ! sodium-independent icosanoid transport + +[Term] +id: GO:0071720 +name: sodium-independent prostaglandin transport +namespace: biological_process +def: "The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] +is_a: GO:0015732 ! prostaglandin transport +is_a: GO:0071718 ! sodium-independent icosanoid transport + +[Term] +id: GO:0071721 +name: sodium-independent thromboxane transport +namespace: biological_process +def: "The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels." [GOC:mah] +is_a: GO:0071717 ! thromboxane transport +is_a: GO:0071718 ! sodium-independent icosanoid transport + +[Term] +id: GO:0071722 +name: detoxification of arsenic-containing substance +namespace: biological_process +def: "Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds." [GOC:kmv, PMID:11313333, PMID:20221439] +synonym: "detoxification of arsenic" EXACT [] +is_a: GO:0098754 ! detoxification +relationship: part_of GO:0046685 ! response to arsenic-containing substance + +[Term] +id: GO:0071723 +name: lipopeptide binding +namespace: molecular_function +def: "Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "bacterial lipopeptide binding" NARROW [GOC:add] +synonym: "bacterial lipoprotein binding" RELATED [GOC:add] +is_a: GO:0008289 ! lipid binding +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:0071724 +name: response to diacyl bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "response to diacylated bacterial lipoprotein" EXACT [GOC:add] +is_a: GO:0070339 ! response to bacterial lipopeptide + +[Term] +id: GO:0071725 +name: response to triacyl bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "response to triacylated bacterial lipoprotein" EXACT [GOC:add] +is_a: GO:0070339 ! response to bacterial lipopeptide + +[Term] +id: GO:0071726 +name: cellular response to diacyl bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "cellular response to diacylated bacterial lipoprotein" EXACT [GOC:add] +is_a: GO:0071221 ! cellular response to bacterial lipopeptide +is_a: GO:0071724 ! response to diacyl bacterial lipopeptide + +[Term] +id: GO:0071727 +name: cellular response to triacyl bacterial lipopeptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794] +comment: Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. +synonym: "cellular response to triacylated bacterial lipoprotein" EXACT [GOC:add] +is_a: GO:0071221 ! cellular response to bacterial lipopeptide +is_a: GO:0071725 ! response to triacyl bacterial lipopeptide + +[Term] +id: GO:0071728 +name: beak development +namespace: biological_process +def: "The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0071729 +name: beak morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0071728 ! beak development + +[Term] +id: GO:0071730 +name: beak formation +namespace: biological_process +def: "The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus." [GOC:lp, ISBN:0702008729] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0071729 ! beak morphogenesis + +[Term] +id: GO:0071731 +name: response to nitric oxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0071732 +name: cellular response to nitric oxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0071731 ! response to nitric oxide +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902170 ! cellular response to reactive nitrogen species + +[Term] +id: GO:0071733 +name: obsolete transcriptional activation by promoter-enhancer looping +namespace: biological_process +def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and enhancer regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:mah, PMID:15060134, PMID:19923429] +comment: This term was obsoleted because it was defined like a molecular function. +synonym: "long-range enhancer-promoter communication" RELATED [PMID:15060134] +is_obsolete: true +consider: GO:0045893 + +[Term] +id: GO:0071734 +name: biotin-[pyruvate-carboxylase] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase)." [GOC:mah, PMID:10551847] +synonym: "biotin-[pyruvate carboxylase] ligase activity" EXACT [GOC:jp] +synonym: "biotin-[pyruvate carboxylase] synthetase activity" EXACT [GOC:mah] +synonym: "biotin-pyruvate carboxylase synthetase activity" EXACT [GOC:mah] +synonym: "biotin-pyruvate-carboxylase ligase activity" EXACT [GOC:mah] +synonym: "biotin:apo-pyruvate-carboxylase ligase" EXACT [GOC:mah] +xref: EC:6.3.4.- +is_a: GO:0018271 ! biotin-protein ligase activity + +[Term] +id: GO:0071735 +name: IgG immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. +synonym: "IgG1" NARROW [GOC:add] +synonym: "IgG2" NARROW [GOC:add] +synonym: "IgG2a" NARROW [GOC:add] +synonym: "IgG2b" NARROW [GOC:add] +synonym: "IgG2c" NARROW [GOC:add] +synonym: "IgG3" NARROW [GOC:add] +synonym: "IgG4" NARROW [GOC:add] +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071736 +name: IgG immunoglobulin complex, circulating +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. +synonym: "IgG antibody" NARROW [GOC:add] +synonym: "IgG1 antibody" NARROW [GOC:add] +synonym: "IgG2 antibody" NARROW [GOC:add] +synonym: "IgG2a antibody" NARROW [GOC:add] +synonym: "IgG2b antibody" NARROW [GOC:add] +synonym: "IgG2c antibody" NARROW [GOC:add] +synonym: "IgG3 antibody" NARROW [GOC:add] +synonym: "IgG4 antibody" NARROW [GOC:add] +is_a: GO:0042571 ! immunoglobulin complex, circulating +is_a: GO:0071735 ! IgG immunoglobulin complex + +[Term] +id: GO:0071737 +name: IgG B cell receptor complex +namespace: cellular_component +def: "An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] +comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. +synonym: "membrane-bound IgG" NARROW [GOC:add] +synonym: "membrane-bound IgG1" NARROW [GOC:add] +synonym: "membrane-bound IgG2" NARROW [GOC:add] +synonym: "membrane-bound IgG2a" NARROW [GOC:add] +synonym: "membrane-bound IgG2b" NARROW [GOC:add] +synonym: "membrane-bound IgG2c" NARROW [GOC:add] +synonym: "membrane-bound IgG3" NARROW [GOC:add] +synonym: "membrane-bound IgG4" NARROW [GOC:add] +synonym: "surface IgG" NARROW [GOC:add] +synonym: "surface IgG1" NARROW [GOC:add] +synonym: "surface IgG2" NARROW [GOC:add] +synonym: "surface IgG2a" NARROW [GOC:add] +synonym: "surface IgG2b" NARROW [GOC:add] +synonym: "surface IgG2c" NARROW [GOC:add] +synonym: "surface IgG3" NARROW [GOC:add] +synonym: "surface IgG4" NARROW [GOC:add] +is_a: GO:0019815 ! B cell receptor complex +is_a: GO:0071735 ! IgG immunoglobulin complex + +[Term] +id: GO:0071738 +name: IgD immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] +comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071739 +name: IgD immunoglobulin complex, circulating +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392] +comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "IgD antibody" EXACT [GOC:add] +is_a: GO:0042571 ! immunoglobulin complex, circulating +is_a: GO:0071738 ! IgD immunoglobulin complex + +[Term] +id: GO:0071740 +name: IgD B cell receptor complex +namespace: cellular_component +def: "An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:11282392] +comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "membrane-bound IgD" EXACT [GOC:add] +synonym: "surface IgD" EXACT [GOC:add] +is_a: GO:0019815 ! B cell receptor complex +is_a: GO:0071738 ! IgD immunoglobulin complex + +[Term] +id: GO:0071741 +name: IgD immunoglobulin complex, GPI-anchored +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells." [GOC:add, ISBN:0781765196, PMID:11282392] +comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "GPI-anchored IgD" EXACT [GOC:add] +is_a: GO:0071738 ! IgD immunoglobulin complex + +[Term] +id: GO:0071742 +name: IgE immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071743 +name: IgE immunoglobulin complex, circulating +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "IgE antibody" EXACT [GOC:add] +is_a: GO:0042571 ! immunoglobulin complex, circulating +is_a: GO:0071742 ! IgE immunoglobulin complex + +[Term] +id: GO:0071744 +name: IgE B cell receptor complex +namespace: cellular_component +def: "An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196] +comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "membrane-bound IgE" EXACT [GOC:add] +synonym: "surface IgE" EXACT [GOC:add] +is_a: GO:0019815 ! B cell receptor complex +is_a: GO:0071742 ! IgE immunoglobulin complex + +[Term] +id: GO:0071745 +name: IgA immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "IgA1 antibody" NARROW [GOC:add] +synonym: "IgA2 antibody" NARROW [GOC:add] +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071746 +name: IgA immunoglobulin complex, circulating +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "IgA antibody" EXACT [GOC:add] +synonym: "IgA1 antibody" NARROW [GOC:add] +synonym: "IgA2 antibody" NARROW [GOC:add] +is_a: GO:0042571 ! immunoglobulin complex, circulating +is_a: GO:0071745 ! IgA immunoglobulin complex + +[Term] +id: GO:0071747 +name: IgA B cell receptor complex +namespace: cellular_component +def: "An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "membrane-bound IgA" NARROW [GOC:add] +synonym: "membrane-bound IgA1" NARROW [GOC:add] +synonym: "membrane-bound IgA2" NARROW [GOC:add] +synonym: "surface IgA" NARROW [GOC:add] +synonym: "surface IgA1" NARROW [GOC:add] +synonym: "surface IgA2" NARROW [GOC:add] +is_a: GO:0019815 ! B cell receptor complex +is_a: GO:0071745 ! IgA immunoglobulin complex + +[Term] +id: GO:0071748 +name: monomeric IgA immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "monomeric IgA antibody" EXACT [GOC:add] +synonym: "monomeric IgA1 antibody" NARROW [GOC:add] +synonym: "monomeric IgA2 antibody" NARROW [GOC:add] +is_a: GO:0071746 ! IgA immunoglobulin complex, circulating + +[Term] +id: GO:0071749 +name: polymeric IgA immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms. +synonym: "pIgA antibody" EXACT [GOC:add] +synonym: "pIgA1 antibody" NARROW [GOC:add] +synonym: "polymeric IgA antibody" EXACT [GOC:add] +synonym: "polymeric IgA1 antibody" NARROW [GOC:add] +is_a: GO:0071746 ! IgA immunoglobulin complex, circulating + +[Term] +id: GO:0071750 +name: dimeric IgA immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. +synonym: "dimeric IgA antibody" EXACT [GOC:add] +synonym: "dimeric IgA1 antibody" NARROW [GOC:add] +is_a: GO:0071749 ! polymeric IgA immunoglobulin complex + +[Term] +id: GO:0071751 +name: secretory IgA immunoglobulin complex +namespace: cellular_component +def: "A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA. +synonym: "secretory IgA antibody" EXACT [GOC:add] +synonym: "sIgA antibody" EXACT [GOC:add] +synonym: "sIgA1 antibody" NARROW [GOC:add] +is_a: GO:0071749 ! polymeric IgA immunoglobulin complex + +[Term] +id: GO:0071752 +name: secretory dimeric IgA immunoglobulin complex +namespace: cellular_component +def: "A dimeric form of secretory IgA immunoglobulin complex." [GOC:add, ISBN:0781765196, PMID:16362985] +comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. +synonym: "secretory dimeric IgA antibody" EXACT [GOC:add] +synonym: "secretory dimeric IgA1 antibody" NARROW [GOC:add] +is_a: GO:0071750 ! dimeric IgA immunoglobulin complex +is_a: GO:0071751 ! secretory IgA immunoglobulin complex + +[Term] +id: GO:0071753 +name: IgM immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] +comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071754 +name: IgM immunoglobulin complex, circulating +namespace: cellular_component +def: "A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268] +comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "IgM antibody" EXACT [GOC:add] +is_a: GO:0042571 ! immunoglobulin complex, circulating +is_a: GO:0071753 ! IgM immunoglobulin complex + +[Term] +id: GO:0071755 +name: IgM B cell receptor complex +namespace: cellular_component +def: "An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:20176268] +comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "membrane-bound IgM" NARROW [GOC:add] +synonym: "surface IgM" NARROW [GOC:add] +is_a: GO:0019815 ! B cell receptor complex +is_a: GO:0071753 ! IgM immunoglobulin complex + +[Term] +id: GO:0071756 +name: pentameric IgM immunoglobulin complex +namespace: cellular_component +def: "A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] +comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "pentameric IgM antibody" EXACT [GOC:add] +is_a: GO:0071754 ! IgM immunoglobulin complex, circulating + +[Term] +id: GO:0071757 +name: hexameric IgM immunoglobulin complex +namespace: cellular_component +def: "A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide." [GOC:add, ISBN:0781765196, PMID:20176268] +comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. +synonym: "hexameric IgM antibody" EXACT [GOC:add] +is_a: GO:0071754 ! IgM immunoglobulin complex, circulating + +[Term] +id: GO:0071758 +name: IgW immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071759 +name: IgX immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071760 +name: IgY immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196] +comment: Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds. +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071761 +name: IgZ immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish." [GOC:add, ISBN:0781765196] +comment: Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout. +synonym: "IgT antibody" NARROW [GOC:add] +synonym: "IgT immunoglobulin complex" EXACT [ISBN:0781765196] +synonym: "IgZ antibody" NARROW [GOC:add] +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071762 +name: heavy chain immunoglobulin complex +namespace: cellular_component +def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains." [GOC:add, ISBN:0781765196, PMID:12543123, PMID:16051357] +comment: Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains. +synonym: "HCab" NARROW [GOC:add] +synonym: "Ig NAR immunoglobulin complex" NARROW [GOC:add] +synonym: "IgNAR antibody" NARROW [GOC:add] +synonym: "IgNAR immunoglobulin complex" NARROW [GOC:add] +is_a: GO:0019814 ! immunoglobulin complex + +[Term] +id: GO:0071763 +name: nuclear membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane." [GOC:mah] +synonym: "nuclear membrane organisation" EXACT [GOC:mah] +synonym: "nuclear membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0006998 ! nuclear envelope organization + +[Term] +id: GO:0071764 +name: nuclear outer membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane." [GOC:mah] +synonym: "nuclear outer membrane organisation" EXACT [GOC:mah] +synonym: "nuclear outer membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071763 ! nuclear membrane organization + +[Term] +id: GO:0071765 +name: nuclear inner membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane." [GOC:mah] +synonym: "nuclear inner membrane organisation" EXACT [GOC:mah] +synonym: "nuclear inner membrane organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071763 ! nuclear membrane organization + +[Term] +id: GO:0071766 +name: Actinobacterium-type cell wall biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface." [GOC:mah, PMID:15653820, PMID:3149973] +is_a: GO:0009273 ! peptidoglycan-based cell wall biogenesis + +[Term] +id: GO:0071767 +name: mycolic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, PMID:15653820] +synonym: "mycolate metabolic process" EXACT [GOC:mah] +synonym: "mycolic acid metabolism" EXACT [GOC:mah] +is_a: GO:0006631 ! fatty acid metabolic process + +[Term] +id: GO:0071768 +name: mycolic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain." [GOC:mah, MetaCyc:PWYG-321, PMID:15653820] +synonym: "mycolate biosynthetic process" EXACT [GOC:mah] +synonym: "mycolic acid anabolism" EXACT [GOC:mah] +synonym: "mycolic acid biosynthesis" EXACT [GOC:mah] +synonym: "mycolic acid formation" EXACT [GOC:mah] +synonym: "mycolic acid synthesis" EXACT [GOC:mah] +xref: MetaCyc:PWYG-321 +is_a: GO:0006633 ! fatty acid biosynthetic process +is_a: GO:0044038 ! cell wall macromolecule biosynthetic process +is_a: GO:0071767 ! mycolic acid metabolic process +relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis + +[Term] +id: GO:0071769 +name: mycolate cell wall layer assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer." [GOC:mah, MetaCyc:PWY-6397, PMID:15653820, PMID:3149973] +synonym: "mycolate cell wall layer biogenesis" RELATED [GOC:mah] +xref: MetaCyc:PWY-6397 +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis + +[Term] +id: GO:0071770 +name: DIM/DIP cell wall layer assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall." [GOC:mah, GOC:pr, PMID:15653820, PMID:3149973] +synonym: "DIM cell wall layer assembly" EXACT [GOC:mah] +synonym: "DIM/DIP cell wall layer biogenesis" RELATED [GOC:mah] +synonym: "PDIM cell wall layer assembly" EXACT [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0071766 ! Actinobacterium-type cell wall biogenesis + +[Term] +id: GO:0071771 +name: aldehyde decarbonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO." [GOC:kad, PMID:6593720, PMID:8718622] +synonym: "decarbonylase activity" EXACT [GOC:kad, GOC:mah] +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0071772 +name: response to BMP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] +synonym: "response to BMP stimulus" EXACT [GOC:dos] +synonym: "response to bone morphogenetic protein stimulus" EXACT [GOC:mah] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0071773 +name: cellular response to BMP stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus." [GOC:mah, GOC:yaf] +synonym: "cellular response to bone morphogenetic protein stimulus" EXACT [GOC:mah] +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:0071772 ! response to BMP + +[Term] +id: GO:0071774 +name: response to fibroblast growth factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus." [GOC:mah] +synonym: "response to FGF stimulus" EXACT [GOC:mah] +synonym: "response to fibroblast growth factor stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:0071778 +name: obsolete WINAC complex +namespace: cellular_component +def: "OBSOLETE. A SWI/SNF-type complex that directly interacts with the vitamin D receptor (VDR) through the Williams syndrome transcription factor (WSTF), and mediates the recruitment of unliganded VDR to VDR target sites in promoters. The WINAC complex contains at least 13 subunits, including WSTF, several SWI/SNF components, and DNA replication-related factors." [GOC:BHF, PMID:12837248] +comment: This term was made obsolete because the paper describing the characterization of this complex, which was used to create this term, has been retracted. +synonym: "WINAC complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:0071781 +name: endoplasmic reticulum cisternal network +namespace: cellular_component +def: "A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells." [GOC:vw, PMID:16469703, PMID:20434336] +synonym: "ER cisternal network" EXACT [GOC:mah] +is_a: GO:0098827 ! endoplasmic reticulum subcompartment + +[Term] +id: GO:0071782 +name: endoplasmic reticulum tubular network +namespace: cellular_component +def: "A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] +synonym: "ER tubular network" EXACT [GOC:mah] +is_a: GO:0098827 ! endoplasmic reticulum subcompartment + +[Term] +id: GO:0071783 +name: endoplasmic reticulum cisternal network organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] +synonym: "endoplasmic reticulum cisternal network organisation" EXACT [GOC:mah] +synonym: "ER cisternal network organisation" EXACT [GOC:mah] +synonym: "ER cisternal network organization" EXACT [GOC:mah] +is_a: GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0071784 +name: endoplasmic reticulum cisternal network assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] +synonym: "endoplasmic reticulum cisternal network formation" EXACT [GOC:mah] +synonym: "ER cisternal network assembly" EXACT [GOC:mah] +synonym: "ER cisternal network formation" EXACT [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization + +[Term] +id: GO:0071785 +name: endoplasmic reticulum cisternal network maintenance +namespace: biological_process +def: "The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] +synonym: "ER cisternal network maintenance" EXACT [GOC:mah] +is_a: GO:0043954 ! cellular component maintenance +is_a: GO:0071783 ! endoplasmic reticulum cisternal network organization + +[Term] +id: GO:0071786 +name: endoplasmic reticulum tubular network organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." [GOC:vw, PMID:16469703, PMID:20434336] +synonym: "endoplasmic reticulum tubular network organisation" EXACT [GOC:mah] +synonym: "ER tubular network organisation" EXACT [GOC:mah] +synonym: "ER tubular network organization" EXACT [GOC:mah] +is_a: GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0071787 +name: endoplasmic reticulum tubular network formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, GOC:vw, PMID:16469703, PMID:20434336] +synonym: "endoplasmic reticulum tubular network assembly" EXACT [] +synonym: "ER tubular network assembly" EXACT [GOC:mah] +synonym: "ER tubular network formation" EXACT [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0071786 ! endoplasmic reticulum tubular network organization + +[Term] +id: GO:0071788 +name: endoplasmic reticulum tubular network maintenance +namespace: biological_process +def: "The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section." [GOC:mah, PMID:16469703, PMID:20434336] +synonym: "ER tubular network maintenance" EXACT [GOC:mah] +is_a: GO:0043954 ! cellular component maintenance +is_a: GO:0071786 ! endoplasmic reticulum tubular network organization + +[Term] +id: GO:0071791 +name: chemokine (C-C motif) ligand 5 binding +namespace: molecular_function +def: "Binding to chemokine (C-C motif) ligand 5." [GOC:add, GOC:amm] +synonym: "CCL5 binding" EXACT [GOC:add, GOC:amm] +synonym: "RANTES binding" EXACT [GOC:bf] +synonym: "Regulated upon Activation, Normal T-cell Expressed, and Secreted binding" EXACT [GOC:add] +is_a: GO:0019957 ! C-C chemokine binding + +[Term] +id: GO:0071792 +name: bacillithiol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] +synonym: "bacillithiol metabolism" EXACT [GOC:mah] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0071793 +name: bacillithiol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bacillithiol, the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid. Bacillithiol, produced widely in the Firmicutes and sporadically in other bacterial lineages, is a low-molecular-weight thiol analogous to mycothiol in the Actinomycetes and glutathione in many species." [GOC:dh, PMID:20308541] +synonym: "bacillithiol anabolism" EXACT [GOC:mah] +synonym: "bacillithiol biosynthesis" EXACT [GOC:mah] +synonym: "bacillithiol formation" EXACT [GOC:mah] +synonym: "bacillithiol synthesis" EXACT [GOC:mah] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0071792 ! bacillithiol metabolic process + +[Term] +id: GO:0071794 +name: CAP-Gly domain binding +namespace: molecular_function +def: "Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets." [GOC:mah, InterPro:IPR000938] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071795 +name: K11-linked polyubiquitin modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein." [GOC:sp, PMID:18775313] +is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding + +[Term] +id: GO:0071796 +name: K6-linked polyubiquitin modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein." [GOC:sp, PMID:17525341, PMID:20351172] +is_a: GO:0031593 ! polyubiquitin modification-dependent protein binding + +[Term] +id: GO:0071797 +name: LUBAC complex +namespace: cellular_component +def: "A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex." [GOC:sp, PMID:17006537, PMID:19136968, PMID:21455180] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:0071798 +name: response to prostaglandin D +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] +synonym: "response to prostaglandin D stimulus" EXACT [GOC:dos] +is_a: GO:0034694 ! response to prostaglandin +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:0071799 +name: cellular response to prostaglandin D stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus." [GOC:sl] +is_a: GO:0071379 ! cellular response to prostaglandin stimulus +is_a: GO:0071798 ! response to prostaglandin D +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0071800 +name: podosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell." [GOC:mah, GOC:sl] +is_a: GO:0065003 ! protein-containing complex assembly +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0071801 +name: regulation of podosome assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of podosome assembly." [GOC:mah, GOC:sl] +comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0071800 ! podosome assembly + +[Term] +id: GO:0071802 +name: negative regulation of podosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate or extent of podosome assembly." [GOC:mah, GOC:sl] +synonym: "down regulation of podosome assembly" EXACT [GOC:mah] +synonym: "down-regulation of podosome assembly" EXACT [GOC:mah] +synonym: "downregulation of podosome assembly" EXACT [GOC:mah] +synonym: "inhibition of podosome assembly" NARROW [GOC:mah] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0071801 ! regulation of podosome assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0071800 ! podosome assembly + +[Term] +id: GO:0071803 +name: positive regulation of podosome assembly +namespace: biological_process +def: "Any process that activates or increases the rate or extent of podosome assembly." [GOC:mah, GOC:sl] +synonym: "activation of podosome assembly" NARROW [GOC:mah] +synonym: "stimulation of podosome assembly" NARROW [GOC:mah] +synonym: "up regulation of podosome assembly" EXACT [GOC:mah] +synonym: "up-regulation of podosome assembly" EXACT [GOC:mah] +synonym: "upregulation of podosome assembly" EXACT [GOC:mah] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0071801 ! regulation of podosome assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0071800 ! podosome assembly + +[Term] +id: GO:0071805 +name: potassium ion transmembrane transport +namespace: biological_process +alt_id: GO:0010163 +def: "A process in which a potassium ion is transported from one side of a membrane to the other." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "high affinity potassium ion import" NARROW [] +synonym: "high affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] +synonym: "high-affinity potassium ion import" NARROW [] +synonym: "high-affinity potassium ion uptake" NARROW [GOC:dph, GOC:tb] +synonym: "potassium ion membrane transport" EXACT [] +is_a: GO:0006813 ! potassium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0071806 +name: protein transmembrane transport +namespace: biological_process +def: "The process in which a protein is transported across a membrane." [GOC:mah, GOC:vw] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "protein membrane transport" EXACT [] +is_a: GO:0015031 ! protein transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0071807 +name: replication fork arrest involved in DNA replication termination +namespace: biological_process +def: "A replication fork arrest process that contributes to the termination of DNA replication." [GOC:mah, PMID:17347517, PMID:20797631] +is_a: GO:0043111 ! replication fork arrest +relationship: part_of GO:0006274 ! DNA replication termination + +[Term] +id: GO:0071808 +name: satellite fibril +namespace: cellular_component +def: "An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section)." [GOC:mah, GOC:sl, PMID:20108326] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0071809 +name: regulation of fever generation by regulation of prostaglandin biosynthesis +namespace: biological_process +def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] +is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process +is_a: GO:0031620 ! regulation of fever generation +relationship: regulates GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process + +[Term] +id: GO:0071810 +name: regulation of fever generation by regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that modulates the rate or extent of fever generation via regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah] +is_a: GO:0031620 ! regulation of fever generation +is_a: GO:0032306 ! regulation of prostaglandin secretion +relationship: regulates GO:0100009 ! regulation of fever generation by prostaglandin secretion + +[Term] +id: GO:0071811 +name: positive regulation of fever generation by positive regulation of prostaglandin biosynthesis +namespace: biological_process +def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:BHF, GOC:dph, GOC:mah] +is_a: GO:0031394 ! positive regulation of prostaglandin biosynthetic process +is_a: GO:0031622 ! positive regulation of fever generation + +[Term] +id: GO:0071812 +name: positive regulation of fever generation by positive regulation of prostaglandin secretion +namespace: biological_process +def: "Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:BHF, GOC:dph, GOC:mah] +is_a: GO:0031622 ! positive regulation of fever generation +is_a: GO:0032308 ! positive regulation of prostaglandin secretion + +[Term] +id: GO:0071813 +name: lipoprotein particle binding +namespace: molecular_function +def: "Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [GOC:BHF, GOC:mah] +synonym: "lipoprotein binding" RELATED [GOC:mah] +synonym: "plasma lipoprotein binding" RELATED [GOC:mah] +synonym: "plasma lipoprotein particle binding" EXACT [GOC:mah] +is_a: GO:0071814 ! protein-lipid complex binding + +[Term] +id: GO:0071814 +name: protein-lipid complex binding +namespace: molecular_function +def: "Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules." [GOC:BHF, GOC:mah] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0071815 +name: intermediate-density lipoprotein particle binding +namespace: molecular_function +def: "Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm." [GOC:BHF, GOC:mah] +synonym: "IDL binding" EXACT [GOC:BHF] +synonym: "intermediate-density lipoprotein binding" EXACT [GOC:dph] +is_a: GO:0071813 ! lipoprotein particle binding + +[Term] +id: GO:0071816 +name: tail-anchored membrane protein insertion into ER membrane +namespace: biological_process +def: "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." [GOC:mah, GOC:sp, PMID:20516149, PMID:20676083] +synonym: "protein insertion of tail-anchored membrane proteins into ER membrane" EXACT [GOC:sp] +synonym: "tail-anchored membrane protein insertion into endoplasmic reticulum membrane" EXACT [GOC:mah] +synonym: "type II transmembrane protein insertion into ER membrane" EXACT [GOC:mah, GOC:sp] +is_a: GO:0045048 ! protein insertion into ER membrane + +[Term] +id: GO:0071817 +name: MMXD complex +namespace: cellular_component +def: "A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation." [GOC:sp, PMID:20797633] +synonym: "MMS19-MIP18-XPD complex" EXACT [GOC:sp, PMID:20797633] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005819 ! spindle + +[Term] +id: GO:0071818 +name: BAT3 complex +namespace: cellular_component +def: "A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A." [GOC:bm, PMID:20676083, PMID:21636303] +synonym: "Bag6 complex" EXACT [PMID:21636303] +synonym: "BAG6-UBL4A-TRC35 complex" EXACT [PMID:21636303] +synonym: "BAT3-TRC35-UBL4A complex" RELATED [PMID:20676083] +is_a: GO:0072379 ! ER membrane insertion complex + +[Term] +id: GO:0071819 +name: DUBm complex +namespace: cellular_component +def: "A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p." [PMID:19226466, PMID:20395473] +synonym: "deubiquitinating module" EXACT [GOC:jp, PMID:20395473] +synonym: "deubiquitination module" EXACT [PMID:19226466] +synonym: "SAGA DUBm complex" NARROW [GOC:jp] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071820 +name: N-box binding +namespace: molecular_function +def: "Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses." [GOC:yaf, PMID:11498047] +synonym: "N box binding" EXACT [GOC:mah] +synonym: "N-box promoter binding" EXACT [GOC:mah] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0071821 +name: FANCM-MHF complex +namespace: cellular_component +def: "A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes." [GOC:mah, GOC:vw, PMID:20347428] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0071823 +name: protein-carbohydrate complex subunit organization +namespace: biological_process +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." [GOC:mah] +synonym: "protein-carbohydrate complex subunit organisation" EXACT [GOC:mah] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0071824 +name: protein-DNA complex subunit organization +namespace: biological_process +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] +synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah] +synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0071825 +name: protein-lipid complex subunit organization +namespace: biological_process +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex." [GOC:mah] +synonym: "protein-lipid complex subunit organisation" EXACT [GOC:mah] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0071826 +name: ribonucleoprotein complex subunit organization +namespace: biological_process +def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] +synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] +synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] +synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] +is_a: GO:0043933 ! protein-containing complex organization + +[Term] +id: GO:0071827 +name: plasma lipoprotein particle organization +namespace: biological_process +def: "A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins." [GOC:BHF, GOC:mah] +synonym: "plasma lipoprotein particle organisation" EXACT [GOC:mah] +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0071825 ! protein-lipid complex subunit organization + +[Term] +id: GO:0071828 +name: apolipoprotein E recycling +namespace: biological_process +def: "The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle." [GOC:BHF, PMID:16373604] +synonym: "APOE recycling" EXACT [GOC:BHF] +is_a: GO:0015031 ! protein transport +relationship: part_of GO:0034380 ! high-density lipoprotein particle assembly +relationship: part_of GO:0034382 ! chylomicron remnant clearance + +[Term] +id: GO:0071829 +name: plasma lipoprotein particle disassembly +namespace: biological_process +def: "The disaggregation of a plasma lipoprotein particle into its constituent components." [GOC:mah] +is_a: GO:0032987 ! protein-lipid complex disassembly +is_a: GO:0071827 ! plasma lipoprotein particle organization +relationship: part_of GO:0097006 ! regulation of plasma lipoprotein particle levels + +[Term] +id: GO:0071830 +name: triglyceride-rich lipoprotein particle clearance +namespace: biological_process +def: "The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] +is_a: GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0071831 +name: intermediate-density lipoprotein particle clearance +namespace: biological_process +def: "The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF] +synonym: "IDL clearance" EXACT [GOC:BHF] +is_a: GO:0071830 ! triglyceride-rich lipoprotein particle clearance + +[Term] +id: GO:0071832 +name: peptide pheromone export involved in regulation of conjugation +namespace: biological_process +def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] +is_a: GO:0000770 ! peptide pheromone export +is_a: GO:0046999 ! regulation of conjugation + +[Term] +id: GO:0071833 +name: peptide pheromone export involved in positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [GOC:elh, GOC:jh, GOC:mah] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion +is_a: GO:0071832 ! peptide pheromone export involved in regulation of conjugation + +[Term] +id: GO:0071834 +name: mating pheromone secretion +namespace: biological_process +def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction." [GOC:mah] +synonym: "mating-type pheromone secretion" EXACT [GOC:vw] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0071835 +name: mating pheromone secretion involved in regulation of conjugation +namespace: biological_process +def: "The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that regulates the union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh, GOC:jh, GOC:mah] +synonym: "mating-type pheromone secretion involved in conjugation" EXACT [GOC:mah, GOC:vw] +is_a: GO:0071834 ! mating pheromone secretion +relationship: part_of GO:0000746 ! conjugation + +[Term] +id: GO:0071836 +name: nectar secretion +namespace: biological_process +def: "The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins." [GOC:kad, PMID:19861655] +synonym: "nectar production" RELATED [GOC:kad] +is_a: GO:0046903 ! secretion + +[Term] +id: GO:0071837 +name: HMG box domain binding +namespace: molecular_function +def: "Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin." [GOC:yaf, InterPro:IPR009071, PMID:18445004] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071838 +name: cell proliferation in bone marrow +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] +synonym: "bone marrow cell proliferation" EXACT [GOC:yaf] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0071839 +name: apoptotic process in bone marrow cell +namespace: biological_process +def: "The apoptotic process in cells in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, PMID:17063141] +synonym: "apoptosis in bone marrow" NARROW [] +synonym: "bone marrow cell apoptosis" EXACT [GOC:yaf] +synonym: "bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] +synonym: "killing of bone marrow cells" EXACT [GOC:mah] +synonym: "programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] +synonym: "programmed cell death, bone marrow cells" EXACT [GOC:mah] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0071840 +name: cellular component organization or biogenesis +namespace: biological_process +alt_id: GO:0071841 +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] +subset: goslim_flybase_ribbon +subset: goslim_metagenomics +synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] +synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] +synonym: "cellular component organization or biogenesis at cellular level" EXACT [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0071846 +name: actin filament debranching +namespace: biological_process +def: "An actin filament severing process that results in the removal of actin filament branches specifically at the branch points." [GOC:jh, GOC:mah, PMID:20362448] +is_a: GO:0051014 ! actin filament severing + +[Term] +id: GO:0071847 +name: TNFSF11-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:signaling, PMID:18606301] +synonym: "RANKL-mediated signaling pathway" EXACT [GOC:BHF] +synonym: "receptor activator of nuclear factor kappa-B ligand signaling pathway" EXACT [Wikipedia:RANKL] +synonym: "TNF-related activation-induced cytokine-mediated signaling pathway" EXACT [Wikipedia:RANKL] +synonym: "TNFSF11-mediated signalling pathway" EXACT [GOC:mah] +synonym: "tumor necrosis factor superfamily member 11-mediated signaling pathway" EXACT [Wikipedia:RANKL] +is_a: GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:0071848 +name: positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling +namespace: biological_process +def: "Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade." [GOC:BHF, PMID:18606301] +synonym: "positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling" EXACT [GOC:BHF] +synonym: "positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling" EXACT [GOC:mah] +is_a: GO:0070374 ! positive regulation of ERK1 and ERK2 cascade +is_a: GO:0071847 ! TNFSF11-mediated signaling pathway + +[Term] +id: GO:0071849 +name: obsolete G1 cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] +comment: This term was obsoleted because it does not represent a specific process. +is_obsolete: true + +[Term] +id: GO:0071851 +name: obsolete mitotic G1 cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. The process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen." [GOC:vw] +comment: This term was obsoleted because it does not represent a specific process. +synonym: "G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:vw] +is_obsolete: true + +[Term] +id: GO:0071852 +name: fungal-type cell wall organization or biogenesis +namespace: biological_process +def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah] +synonym: "fungal-type cell wall organisation or biogenesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:0071853 +name: fungal-type cell wall disassembly +namespace: biological_process +def: "A cellular process that results in the breakdown of a fungal-type cell wall." [GOC:mah] +is_a: GO:0031505 ! fungal-type cell wall organization +is_a: GO:0044277 ! cell wall disassembly + +[Term] +id: GO:0071854 +name: cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly +namespace: biological_process +def: "The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall." [GOC:mah] +is_a: GO:0070910 ! cell wall macromolecule catabolic process involved in cell wall disassembly +relationship: part_of GO:0071853 ! fungal-type cell wall disassembly + +[Term] +id: GO:0071855 +name: neuropeptide receptor binding +namespace: molecular_function +def: "Binding to a neuropeptide receptor." [GOC:kmv, GOC:mah] +is_a: GO:0001664 ! G protein-coupled receptor binding + +[Term] +id: GO:0071857 +name: beta-endorphin receptor binding +namespace: molecular_function +def: "Binding to a beta-endorphin receptor." [GOC:kmv, GOC:mah] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0071858 +name: corazonin receptor binding +namespace: molecular_function +def: "Binding to a corazonin receptor." [GOC:kmv, GOC:mah] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0071859 +name: neuropeptide F receptor binding +namespace: molecular_function +def: "Binding to a neuropeptide F receptor." [GOC:kmv, GOC:mah] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0071860 +name: proctolin receptor binding +namespace: molecular_function +def: "Binding to a proctolin receptor." [GOC:kmv, GOC:mah] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0071861 +name: tachykinin receptor binding +namespace: molecular_function +def: "Binding to a tachykinin receptor." [GOC:kmv, GOC:mah] +is_a: GO:0071855 ! neuropeptide receptor binding + +[Term] +id: GO:0071863 +name: regulation of cell proliferation in bone marrow +namespace: biological_process +def: "A process that modulates the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] +synonym: "regulation of bone marrow cell proliferation" EXACT [GOC:yaf] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0071838 ! cell proliferation in bone marrow + +[Term] +id: GO:0071864 +name: positive regulation of cell proliferation in bone marrow +namespace: biological_process +def: "A process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." [GOC:mah, GOC:yaf, PMID:17063141] +synonym: "activation of cell proliferation in bone marrow" NARROW [GOC:mah] +synonym: "positive regulation of bone marrow cell proliferation" EXACT [GOC:yaf] +synonym: "stimulation of cell proliferation in bone marrow" NARROW [GOC:mah] +synonym: "up regulation of cell proliferation in bone marrow" EXACT [GOC:mah] +synonym: "up-regulation of cell proliferation in bone marrow" EXACT [GOC:mah] +synonym: "upregulation of cell proliferation in bone marrow" EXACT [GOC:mah] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0071863 ! regulation of cell proliferation in bone marrow +relationship: positively_regulates GO:0071838 ! cell proliferation in bone marrow + +[Term] +id: GO:0071865 +name: regulation of apoptotic process in bone marrow cell +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141] +synonym: "regulation of apoptosis in bone marrow" NARROW [] +synonym: "regulation of apoptotic process in bone marrow" EXACT [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0071839 ! apoptotic process in bone marrow cell + +[Term] +id: GO:0071866 +name: negative regulation of apoptotic process in bone marrow cell +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow." [GOC:mah, GOC:mtg_apoptosis, GOC:yaf, PMID:17063141] +synonym: "down regulation of apoptosis in bone marrow" EXACT [GOC:mah] +synonym: "down-regulation of apoptosis in bone marrow" EXACT [GOC:mah] +synonym: "downregulation of apoptosis in bone marrow" EXACT [GOC:mah] +synonym: "inhibition of apoptosis in bone marrow" NARROW [GOC:mah] +synonym: "negative regulation of apoptosis in bone marrow" NARROW [] +synonym: "negative regulation of apoptotic process in bone marrow" EXACT [] +synonym: "negative regulation of bone marrow cell apoptosis" EXACT [GOC:mah, GOC:yaf] +synonym: "negative regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:mah] +synonym: "negative regulation of killing of bone marrow cells" EXACT [GOC:mah] +synonym: "negative regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:mah] +synonym: "negative regulation of programmed cell death, bone marrow cells" EXACT [GOC:mah] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell +relationship: negatively_regulates GO:0071839 ! apoptotic process in bone marrow cell + +[Term] +id: GO:0071867 +name: response to monoamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] +synonym: "response to monoamine stimulus" EXACT [GOC:dos] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0071868 +name: cellular response to monoamine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan." [GOC:mah] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0071867 ! response to monoamine + +[Term] +id: GO:0071869 +name: response to catecholamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] +synonym: "response to catecholamine stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0071867 ! response to monoamine +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0071870 +name: cellular response to catecholamine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution." [GOC:BHF, GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071868 ! cellular response to monoamine stimulus +is_a: GO:0071869 ! response to catecholamine +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0071871 +name: response to epinephrine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [GOC:BHF, GOC:mah] +comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. +synonym: "response to adrenaline stimulus" EXACT [GOC:mah] +synonym: "response to epinephrine stimulus" EXACT [GOC:dos] +is_a: GO:0071869 ! response to catecholamine + +[Term] +id: GO:0071872 +name: cellular response to epinephrine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system." [GOC:BHF, GOC:mah] +comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. +synonym: "cellular response to adrenaline stimulus" EXACT [GOC:mah] +is_a: GO:0071870 ! cellular response to catecholamine stimulus +is_a: GO:0071871 ! response to epinephrine + +[Term] +id: GO:0071873 +name: response to norepinephrine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] +comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. +synonym: "response to noradrenaline stimulus" EXACT [GOC:mah] +synonym: "response to norepinephrine stimulus" EXACT [GOC:dos] +is_a: GO:0071869 ! response to catecholamine + +[Term] +id: GO:0071874 +name: cellular response to norepinephrine stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system." [GOC:BHF, GOC:mah] +comment: Note that epinephrine and norepinephrine are ligands for the same receptors, and there are multiple adrenergic receptors. +synonym: "cellular response to noradrenaline stimulus" EXACT [GOC:mah] +is_a: GO:0071870 ! cellular response to catecholamine stimulus +is_a: GO:0071873 ! response to norepinephrine + +[Term] +id: GO:0071875 +name: adrenergic receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF] +synonym: "adrenergic receptor signalling pathway" EXACT [GOC:mah] +synonym: "adrenoceptor signaling pathway" EXACT [GOC:mah] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0071876 +name: obsolete initiation of adrenergic receptor signal transduction +namespace: biological_process +def: "OBSOLETE. A process of signal initiation in which epinephrine or norepinephrine causes activation of an adrenergic receptor." [GOC:BHF, GOC:mah] +comment: This term was made obsolete because the meaning of the term is ambiguous. +synonym: "initiation of adrenergic receptor signal transduction" EXACT [] +is_obsolete: true +consider: GO:0004935 +consider: GO:0005179 +consider: GO:0071872 +consider: GO:0071874 +consider: GO:0071875 + +[Term] +id: GO:0071877 +name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] +synonym: "regulation of adrenergic receptor signaling pathway" EXACT [] +synonym: "regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway + +[Term] +id: GO:0071878 +name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor protein signaling pathway activity. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] +synonym: "negative regulation of adrenergic receptor signaling pathway" EXACT [] +synonym: "negative regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +relationship: negatively_regulates GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway + +[Term] +id: GO:0071879 +name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the adenylate cyclase-activating adrenergic receptor protein signaling pathway. An adrenergic receptor signaling pathway is the series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands." [GOC:BHF, GOC:mah] +synonym: "positive regulation of adrenergic receptor signaling pathway" BROAD [] +synonym: "positive regulation of adrenergic receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +relationship: positively_regulates GO:0071875 ! adrenergic receptor signaling pathway + +[Term] +id: GO:0071880 +name: adenylate cyclase-activating adrenergic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling] +synonym: "activation of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling] +synonym: "activation of adenylate cyclase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] +synonym: "adrenergic receptor, adenylate cyclase activating pathway" EXACT [GOC:mah] +synonym: "adrenergic receptor, adenylyl cyclase activating pathway" EXACT [GOC:mah] +is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:0071875 ! adrenergic receptor signaling pathway + +[Term] +id: GO:0071881 +name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:BHF, GOC:mah, GOC:signaling] +synonym: "adrenergic receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:mah] +synonym: "adrenergic receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:mah] +synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway" RELATED [GOC:signaling] +synonym: "inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway" RELATED [GOC:mah] +is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway +is_a: GO:0071875 ! adrenergic receptor signaling pathway + +[Term] +id: GO:0071882 +name: phospholipase C-activating adrenergic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:BHF, GOC:mah, GOC:signaling] +synonym: "activation of phospholipase C activity by adrenergic receptor signaling pathway" RELATED [GOC:bf] +synonym: "activation of phospholipase C activity by adrenergic receptor signalling pathway" RELATED [GOC:mah] +synonym: "adrenergic receptor, phospholipase C activating pathway" RELATED [GOC:mah] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0071875 ! adrenergic receptor signaling pathway + +[Term] +id: GO:0071883 +name: MAPK-activating adrenergic receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade." [GOC:BHF, GOC:mah] +synonym: "activation of MAP kinase activity by adrenergic receptor signaling pathway" EXACT [GOC:mah] +synonym: "activation of MAP kinase activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] +synonym: "activation of MAPK activity by adrenergic receptor signaling pathway" EXACT [] +synonym: "activation of MAPK activity by adrenergic receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0071875 ! adrenergic receptor signaling pathway + +[Term] +id: GO:0071885 +name: N-terminal protein N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser." [PMID:20481588] +synonym: "X-Pro-Lys N-terminal methyltransferase" NARROW [GOC:rn] +is_a: GO:0008276 ! protein methyltransferase activity + +[Term] +id: GO:0071886 +name: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding +namespace: molecular_function +def: "Binding to the amine 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine, a serotonin receptor agonist that can act as a psychedelic drug." [GOC:yaf, PMID:19057895] +synonym: "(+/-)2-(4-iodo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine binding" EXACT [CHEBI:100436] +synonym: "1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane binding" EXACT [PMID:19057895] +synonym: "4-iodo-2,5-dimethoxyphenylisopropylamine binding" EXACT [PubChem_Compound:1229] +is_a: GO:0043176 ! amine binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0071887 +name: leukocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "leukocyte apoptosis" NARROW [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0071888 +name: macrophage apoptotic process +namespace: biological_process +def: "Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues." [CL:0000235, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +comment: Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). +synonym: "activation-induced cell death" RELATED [GOC:yaf] +synonym: "AICD" RELATED [GOC:yaf] +synonym: "macrophage apoptosis" NARROW [] +is_a: GO:0006925 ! inflammatory cell apoptotic process +is_a: GO:0033028 ! myeloid cell apoptotic process +is_a: GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:0071889 +name: 14-3-3 protein binding +namespace: molecular_function +def: "Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0071890 +name: bicarbonate binding +namespace: molecular_function +def: "Binding to bicarbonate ions (CHO3-)." [GOC:curators] +synonym: "CHO3- ion binding binding" EXACT [] +synonym: "hydrogencarbonate binding" EXACT [CHEBI:17544] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0071891 +name: N-terminal peptidyl-proline dimethylation involved in translation +namespace: biological_process +def: "An N-terminal peptidyl-proline dimethylation process that contributes to translation." [GOC:mah] +is_a: GO:0018016 ! N-terminal peptidyl-proline dimethylation +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:0071892 +name: thrombocyte activation +namespace: biological_process +def: "A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals." [GOC:lb, GOC:mah, PMID:10606877, PMID:15634265, PMID:20180901] +synonym: "blood coagulation, thrombocyte activation" EXACT [GOC:mah] +is_a: GO:0001775 ! cell activation +relationship: part_of GO:0007596 ! blood coagulation + +[Term] +id: GO:0071893 +name: BMP signaling pathway involved in nephric duct formation +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation." [GOC:mah, GOC:mtg_kidney_jan10] +synonym: "BMP signalling pathway involved in nephric duct formation" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +relationship: part_of GO:0072179 ! nephric duct formation + +[Term] +id: GO:0071894 +name: histone H2B conserved C-terminal lysine ubiquitination +namespace: biological_process +def: "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:mah, GOC:vw] +synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw] +synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw] +synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw] +is_a: GO:0033523 ! histone H2B ubiquitination + +[Term] +id: GO:0071895 +name: odontoblast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin." [GOC:sl, PMID:20425127] +is_a: GO:0060563 ! neuroepithelial cell differentiation + +[Term] +id: GO:0071896 +name: protein localization to adherens junction +namespace: biological_process +alt_id: GO:1904696 +def: "Any process in which a protein is transported to, and/or maintained at the adherens junction." [GOC:aruk, GOC:bc, GOC:BHF, GOC:mah, PMID:26412237] +synonym: "protein localisation in adherens junction" EXACT [] +synonym: "protein localisation in cell-cell adherens junction" EXACT [] +synonym: "protein localisation to adherens junction" EXACT [GOC:mah] +synonym: "protein localisation to cell-cell adherens junction" EXACT [] +synonym: "protein localization in adherens junction" EXACT [] +synonym: "protein localization in cell-cell adherens junction" EXACT [] +synonym: "protein localization to cell-cell adherens junction" EXACT [] +is_a: GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0071897 +name: DNA biosynthetic process +namespace: biological_process +def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah] +synonym: "DNA anabolism" EXACT [GOC:mah] +synonym: "DNA biosynthesis" EXACT [GOC:mah] +synonym: "DNA formation" EXACT [GOC:mah] +synonym: "DNA synthesis" EXACT [GOC:mah] +is_a: GO:0006259 ! DNA metabolic process +is_a: GO:0034645 ! cellular macromolecule biosynthetic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process + +[Term] +id: GO:0071898 +name: obsolete regulation of estrogen receptor binding +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of estrogen receptor binding, interacting selectively with a an estrogen receptor." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0071899 +name: obsolete negative regulation of estrogen receptor binding +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of estrogen receptor binding, interacting selectively with an estrogen receptor." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0071900 +name: regulation of protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:0071901 +name: negative regulation of protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0071902 +name: positive regulation of protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:0071903 +name: protein N-linked N-acetylglucosaminylation via asparagine +namespace: biological_process +def: "A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0151] +synonym: "protein amino acid N-linked N-acetylglucosaminylation via asparagine" EXACT [GOC:bf] +xref: RESID:AA0151 +is_a: GO:0018279 ! protein N-linked glycosylation via asparagine +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0071904 +name: protein N-linked N-acetylgalactosaminylation via asparagine +namespace: biological_process +def: "A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0420] +synonym: "protein amino acid N-linked N-acetylgalactosaminylation via asparagine" EXACT [GOC:bf] +xref: RESID:AA0420 +is_a: GO:0018279 ! protein N-linked glycosylation via asparagine +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0071905 +name: protein N-linked glucosylation via asparagine +namespace: biological_process +def: "A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue." [GOC:pr, RESID:AA0421] +synonym: "protein amino acid N-linked glucosylation via asparagine" EXACT [GOC:bf] +xref: RESID:AA0421 +is_a: GO:0018279 ! protein N-linked glycosylation via asparagine + +[Term] +id: GO:0071906 +name: CRD domain binding +namespace: molecular_function +def: "Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins." [GOC:yaf, PMID:19460168] +synonym: "context dependent regulatory domain binding" EXACT [GOC:mah] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071907 +name: determination of digestive tract left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed." [GOC:cvs] +synonym: "determination of gut left/right asymmetry" EXACT [GOC:cvs] +synonym: "determination of left/right asymmetry of the digestive tract" EXACT [GOC:cvs] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0048565 ! digestive tract development + +[Term] +id: GO:0071908 +name: determination of intestine left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism." [GOC:cvs] +is_a: GO:0071907 ! determination of digestive tract left/right asymmetry + +[Term] +id: GO:0071909 +name: determination of stomach left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism." [GOC:cvs] +is_a: GO:0071907 ! determination of digestive tract left/right asymmetry +relationship: part_of GO:0062094 ! stomach development + +[Term] +id: GO:0071910 +name: determination of liver left/right asymmetry +namespace: biological_process +def: "Determination of the asymmetric location of the liver with respect to the left and right halves of the organism." [GOC:cvs] +is_a: GO:0007368 ! determination of left/right symmetry +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0071911 +name: synchronous neurotransmitter secretion +namespace: biological_process +def: "Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0071912 +name: asynchronous neurotransmitter secretion +namespace: biological_process +def: "Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion." [GOC:dsf, PMID:19477156, PMID:20643933] +is_a: GO:0007269 ! neurotransmitter secretion + +[Term] +id: GO:0071913 +name: citrate secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of citrate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mah, GOC:mtg_transport, GOC:vw] +synonym: "citrate carrier activity" EXACT [GOC:mah] +is_a: GO:0005371 ! tricarboxylate secondary active transmembrane transporter activity +is_a: GO:0015137 ! citrate transmembrane transporter activity + +[Term] +id: GO:0071914 +name: prominosome +namespace: cellular_component +def: "An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known." [GOC:vesicles, PMID:15976444, PMID:17109118, PMID:17283184] +synonym: "prominin-containing extracellular membrane vesicle" EXACT [] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:0071915 +name: protein-lysine lysylation +namespace: biological_process +def: "The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:imk, GOC:jsg, PMID:20729861] +synonym: "protein amino acid lysylation" EXACT [GOC:imk] +is_a: GO:0018205 ! peptidyl-lysine modification +relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification + +[Term] +id: GO:0071916 +name: dipeptide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0042936 +def: "Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond." [GOC:mah] +synonym: "dipeptide transporter activity" RELATED [] +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:0071917 +name: triose-phosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a triose phosphate from one side of a membrane to the other." [GOC:mah, GOC:vw] +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:0071918 +name: urea transmembrane transport +namespace: biological_process +def: "The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "urea membrane transport" EXACT [] +is_a: GO:0015840 ! urea transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0071919 +name: G-quadruplex DNA formation +namespace: biological_process +def: "A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature." [GOC:sre, PMID:20098422] +synonym: "G quadruplex DNA formation" EXACT [GOC:mah] +synonym: "G quartet DNA formation" EXACT [GOC:mah] +synonym: "G-quartet DNA formation" EXACT [GOC:mah] +is_a: GO:0006259 ! DNA metabolic process + +[Term] +id: GO:0071920 +name: cleavage body +namespace: cellular_component +def: "A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing." [PMID:10564273, PMID:11598190, PMID:8654386] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0071921 +name: cohesin loading +namespace: biological_process +def: "The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA." [GOC:dph, GOC:mah, GOC:vw, PMID:10882066, PMID:17113138, PMID:26687354] +synonym: "cohesin association with chromatin" EXACT [GOC:lb] +synonym: "cohesin localisation to chromatin" EXACT [GOC:mah] +synonym: "cohesin localization to chromatin" EXACT [GOC:vw] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0071168 ! protein localization to chromatin +relationship: part_of GO:0034085 ! establishment of sister chromatid cohesion + +[Term] +id: GO:0071922 +name: regulation of cohesin loading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] +synonym: "regulation of cohesin association with chromatin" EXACT [GOC:lb] +synonym: "regulation of cohesin localisation to chromatin" EXACT [GOC:mah] +synonym: "regulation of cohesin localization to chromatin" EXACT [GOC:vw] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:1905634 ! regulation of protein localization to chromatin +relationship: regulates GO:0071921 ! cohesin loading + +[Term] +id: GO:0071923 +name: negative regulation of cohesin loading +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:lb, GOC:mah, PMID:17113138] +synonym: "negative regulation of cohesin association with chromatin" EXACT [GOC:lb] +synonym: "negative regulation of cohesin localisation to chromatin" EXACT [GOC:mah] +synonym: "negative regulation of cohesin localization to chromatin" RELATED [GOC:vw] +is_a: GO:0045875 ! negative regulation of sister chromatid cohesion +is_a: GO:0071922 ! regulation of cohesin loading +is_a: GO:0120186 ! negative regulation of protein localization to chromatin +relationship: negatively_regulates GO:0071921 ! cohesin loading + +[Term] +id: GO:0071924 +name: chemokine (C-C motif) ligand 22 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:18832724] +subset: gocheck_do_not_annotate +synonym: "C-C motif chemokine 22 production" EXACT [GOC:mah] +synonym: "CCL-22 production" EXACT [GOC:mah] +synonym: "CCL22 production" EXACT [GOC:mah] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071925 +name: thymic stromal lymphopoietin production +namespace: biological_process +def: "The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:17129180] +subset: gocheck_do_not_annotate +synonym: "TSLP production" EXACT [GOC:mah] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071926 +name: endocannabinoid signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol." [GOC:bf, GOC:mah, PMID:15550444] +synonym: "endocannabinoid signalling pathway" EXACT [GOC:mah] +is_a: GO:0038171 ! cannabinoid signaling pathway + +[Term] +id: GO:0071927 +name: octopamine signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor." [GOC:mah, PMID:15355245] +synonym: "octopamine signalling pathway" EXACT [GOC:mah] +is_a: GO:0007211 ! octopamine or tyramine signaling pathway + +[Term] +id: GO:0071928 +name: tyramine signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor." [GOC:mah, PMID:15355245] +synonym: "tyramine signalling pathway" EXACT [GOC:mah] +is_a: GO:0007211 ! octopamine or tyramine signaling pathway + +[Term] +id: GO:0071929 +name: alpha-tubulin acetylation +namespace: biological_process +def: "The addition of an acetyl group to the lysine 40 residue of alpha-tubulin." [GOC:kmv, PMID:17786050] +is_a: GO:0018393 ! internal peptidyl-lysine acetylation + +[Term] +id: GO:0071930 +name: negative regulation of transcription involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] +synonym: "negative regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] +is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0071931 +name: positive regulation of transcription involved in G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle." [GOC:mah, GOC:vw] +synonym: "positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle" RELATED [GOC:mah] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle" EXACT [GOC:mah] +is_a: GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated + +[Term] +id: GO:0071932 +name: replication fork reversal +namespace: biological_process +def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929] +is_a: GO:0031297 ! replication fork processing + +[Term] +id: GO:0071933 +name: Arp2/3 complex binding +namespace: molecular_function +def: "Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5)." [GOC:mah] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0071934 +name: thiamine transmembrane transport +namespace: biological_process +def: "The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "thiamin transmembrane transport" EXACT [GOC:mah] +synonym: "thiamine membrane transport" EXACT [] +synonym: "vitamin B1 transmembrane transport" EXACT [GOC:mah] +is_a: GO:0015888 ! thiamine transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0045117 ! azole transmembrane transport +is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:0071935 +name: octopamine signaling pathway involved in response to food +namespace: biological_process +def: "The series of molecular signals initiated by binding of octopamine to a receptor on the surface of the target cell that contributes to a response to a food stimulus." [GOC:mah, PMID:19609300] +synonym: "octopamine signalling pathway involved in response to food" EXACT [GOC:mah] +is_a: GO:0071927 ! octopamine signaling pathway +relationship: part_of GO:0032094 ! response to food + +[Term] +id: GO:0071936 +name: coreceptor activity involved in Wnt signaling pathway +namespace: molecular_function +def: "In cooperation with a primary Wnt receptor, initiating a change in cell activity through the Wnt signaling pathway." [GOC:BHF, GOC:mah] +synonym: "coreceptor activity involved in Wnt receptor signaling pathway" EXACT [] +synonym: "coreceptor activity involved in Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "coreceptor activity involved in Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "Wnt co-receptor activity" EXACT [GOC:bf] +is_a: GO:0015026 ! coreceptor activity + +[Term] +id: GO:0071938 +name: vitamin A transport +namespace: biological_process +def: "The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] +synonym: "vitamin A uptake and transport" RELATED [GOC:rs] +is_a: GO:0046865 ! terpenoid transport +is_a: GO:0051180 ! vitamin transport + +[Term] +id: GO:0071939 +name: vitamin A import +namespace: biological_process +def: "The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." [GOC:mah, PMID:16011460, PMID:1924551] +synonym: "vitamin A uptake" EXACT [GOC:mah, GOC:rs] +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0071938 ! vitamin A transport + +[Term] +id: GO:0071940 +name: fungal-type cell wall assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah, GOC:vw, PMID:19646873] +synonym: "fungal-type cell wall formation" RELATED [GOC:mah] +is_a: GO:0031505 ! fungal-type cell wall organization +is_a: GO:0070726 ! cell wall assembly +relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis + +[Term] +id: GO:0071941 +name: nitrogen cycle metabolic process +namespace: biological_process +def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] +subset: goslim_chembl +subset: goslim_generic +subset: goslim_pombe +xref: Wikipedia:Nitrogen_cycle +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0071942 +name: XPC complex +namespace: cellular_component +def: "A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2." [PMID:11279143, PMID:15964821, PMID:19941824] +is_a: GO:0000109 ! nucleotide-excision repair complex + +[Term] +id: GO:0071943 +name: Myc-Max complex +namespace: cellular_component +def: "A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max." [GOC:cna, PMID:16620027, PMID:16620031, PMID:20170194] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0071944 +name: cell periphery +namespace: cellular_component +def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] +subset: goslim_flybase_ribbon +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0071945 +name: regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed +namespace: biological_process +def: "A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein." [GOC:cilia, GOC:jl, PMID:20371342] +synonym: "regulation of bacterial-type flagellar cell motility by regulation of motor speed" RELATED [] +synonym: "regulation of bacterial-type flagellum cell motility by regulation of motor speed" EXACT [] +synonym: "regulation of flagellar cell motility by regulation of motor speed" BROAD [] +is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:0071946 +name: cis-acting DNA replication termination +namespace: biological_process +def: "A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing." [GOC:vw, PMID:20850009] +synonym: "cis acting DNA replication termination" EXACT [GOC:vw] +is_a: GO:0071170 ! site-specific DNA replication termination + +[Term] +id: GO:0071947 +name: protein deubiquitination involved in ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The removal of one or more ubiquitin groups from a protein as part of a process of ubiquitin-dependent protein catabolism." [GOC:mah] +is_a: GO:0016579 ! protein deubiquitination +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0071948 +name: activation-induced B cell apoptotic process +namespace: biological_process +def: "B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death." [GOC:mtg_apoptosis, GOC:tfm, PMID:11032170, PMID:19300454] +synonym: "activated B cell apoptosis" BROAD [GOC:tfm] +synonym: "activation-induced B cell apoptosis" NARROW [] +synonym: "activation-induced B-cell apoptosis" EXACT [GOC:tfm] +synonym: "activation-induced cell death of B cells" EXACT [GOC:tfm] +synonym: "activation-induced cell death of B lymphocytes" EXACT [GOC:tfm] +synonym: "activation-induced cell death of B-cells" EXACT [GOC:tfm] +synonym: "activation-induced cell death of B-lymphocytes" EXACT [GOC:tfm] +synonym: "AICD" BROAD [GOC:tfm] +synonym: "antigen-driven apoptosis" BROAD [GOC:tfm] +is_a: GO:0001783 ! B cell apoptotic process + +[Term] +id: GO:0071949 +name: FAD binding +namespace: molecular_function +def: "Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +synonym: "oxidized flavin adenine dinucleotide binding" EXACT [GOC:mah] +synonym: "oxidized flavine-adenine dinucleotide binding" EXACT [GOC:mah] +is_a: GO:0050660 ! flavin adenine dinucleotide binding + +[Term] +id: GO:0071950 +name: FADH2 binding +namespace: molecular_function +def: "Binding to the reduced form, FADH2, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +synonym: "reduced flavin adenine dinucleotide binding" EXACT [GOC:mah] +synonym: "reduced flavine-adenine dinucleotide binding" EXACT [GOC:mah] +is_a: GO:0050660 ! flavin adenine dinucleotide binding + +[Term] +id: GO:0071951 +name: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA +namespace: biological_process +def: "The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet)." [GOC:jsg, PMID:5337045] +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0071952 +name: conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA +namespace: biological_process +def: "The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA." [GOC:jsg, PMID:17351629, PMID:18559341] +comment: Note that this process has been observed in some archaeal and bacterial species. +is_a: GO:0019988 ! charged-tRNA amino acid modification + +[Term] +id: GO:0071953 +name: elastic fiber +namespace: cellular_component +def: "An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain." [GOC:BHF, GOC:mah, PMID:20236620] +synonym: "elastic fibre" EXACT [GOC:mah] +synonym: "elastin fiber" EXACT [GOC:BHF] +is_a: GO:0099512 ! supramolecular fiber +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:0071954 +name: chemokine (C-C motif) ligand 11 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, PMID:9600955] +subset: gocheck_do_not_annotate +synonym: "C-C motif chemokine 11 production" EXACT [GOC:mah] +synonym: "CCL-11 production" EXACT [GOC:mah] +synonym: "CCL11 production" EXACT [GOC:mah] +synonym: "eotaxin production" BROAD [GOC:mah] +synonym: "eotaxin-1 production" EXACT [GOC:mah] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0071955 +name: recycling endosome to Golgi transport +namespace: biological_process +def: "The directed movement of substances from recycling endosomes to the Golgi." [GOC:lb] +is_a: GO:0042147 ! retrograde transport, endosome to Golgi +is_a: GO:0048193 ! Golgi vesicle transport + +[Term] +id: GO:0071957 +name: old mitotic spindle pole body +namespace: cellular_component +def: "The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis." [GOC:mah, GOC:vw, PMID:15132994] +synonym: "old SPB" EXACT [GOC:mah] +is_a: GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0071958 +name: new mitotic spindle pole body +namespace: cellular_component +def: "The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize." [GOC:mah, GOC:vw, PMID:15132994] +synonym: "new SPB" EXACT [GOC:mah] +is_a: GO:0044732 ! mitotic spindle pole body + +[Term] +id: GO:0071959 +name: maintenance of mitotic sister chromatid cohesion, arms +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] +synonym: "maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:mah] +synonym: "maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:mah] +is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion +relationship: part_of GO:0071961 ! mitotic sister chromatid cohesion, arms + +[Term] +id: GO:0071960 +name: maintenance of mitotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:mah, PMID:1708436] +synonym: "maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] +synonym: "maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:mah] +synonym: "maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:mah] +is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion +relationship: part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric + +[Term] +id: GO:0071961 +name: mitotic sister chromatid cohesion, arms +namespace: biological_process +def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis." [GOC:mah] +synonym: "mitotic sister chromatid cohesion along arms" EXACT [GOC:mah] +synonym: "sister chromatid cohesion along arms at mitosis" EXACT [GOC:mah] +is_a: GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0071962 +name: mitotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah] +synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] +synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah] +synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah] +is_a: GO:0007064 ! mitotic sister chromatid cohesion +is_a: GO:0070601 ! centromeric sister chromatid cohesion + +[Term] +id: GO:0071963 +name: establishment or maintenance of cell polarity regulating cell shape +namespace: biological_process +def: "Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell." [GOC:mah] +is_a: GO:0007163 ! establishment or maintenance of cell polarity +is_a: GO:0008360 ! regulation of cell shape + +[Term] +id: GO:0071964 +name: establishment of cell polarity regulating cell shape +namespace: biological_process +def: "Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell." [GOC:mah] +is_a: GO:0030010 ! establishment of cell polarity +is_a: GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:0071965 +name: multicellular organismal locomotion +namespace: biological_process +def: "Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another." [GOC:mah] +is_a: GO:0040011 ! locomotion +is_a: GO:0050879 ! multicellular organismal movement + +[Term] +id: GO:0071966 +name: fungal-type cell wall polysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall." [GOC:mah] +is_a: GO:0010383 ! cell wall polysaccharide metabolic process +relationship: part_of GO:0071852 ! fungal-type cell wall organization or biogenesis + +[Term] +id: GO:0071967 +name: lipopolysaccharide core heptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+." [MetaCyc:RXN0-5122] +synonym: "LPS core heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] +xref: MetaCyc:RXN0-5122 +xref: RHEA:29923 +is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity + +[Term] +id: GO:0071968 +name: lipid A-core heptosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+." [MetaCyc:RXN0-5127] +xref: MetaCyc:RXN0-5127 +xref: RHEA:30019 +is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity + +[Term] +id: GO:0071969 +name: fungal-type cell wall (1->3)-beta-D-glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi." [GOC:mah] +synonym: "fungal-type cell wall 1,3-beta-D-glucan metabolic process" EXACT [] +synonym: "fungal-type cell wall 1,3-beta-glucan metabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3 glucan metabolic process" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3 glucan metabolism" EXACT [GOC:mah] +is_a: GO:0034407 ! cell wall (1->3)-beta-D-glucan metabolic process +is_a: GO:0070879 ! fungal-type cell wall beta-glucan metabolic process + +[Term] +id: GO:0071970 +name: fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls." [GOC:mah] +synonym: "fungal-type cell wall 1,3-beta-D-glucan biosynthetic process" EXACT [] +synonym: "fungal-type cell wall 1,3-beta-glucan anabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-beta-glucan biosynthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-beta-glucan formation" EXACT [GOC:mah] +synonym: "fungal-type cell wall 1,3-beta-glucan synthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3-glucan anabolism" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3-glucan biosynthesis" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3-glucan biosynthetic process" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3-glucan formation" EXACT [GOC:mah] +synonym: "fungal-type cell wall beta-1,3-glucan synthesis" EXACT [GOC:mah] +is_a: GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process +is_a: GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process +is_a: GO:0071969 ! fungal-type cell wall (1->3)-beta-D-glucan metabolic process + +[Term] +id: GO:0071971 +name: extracellular exosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm." [GOC:mah, GOC:tfm, PMID:19442504, PMID:27462458] +synonym: "extracellular vesicular exosome assembly" EXACT [GOC:vesicles] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0070925 ! organelle assembly +relationship: part_of GO:0097734 ! extracellular exosome biogenesis + +[Term] +id: GO:0071972 +name: peptidoglycan L,D-transpeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine." [MetaCyc:RXN-11349] +xref: MetaCyc:RXN-11349 +is_a: GO:0004185 ! serine-type carboxypeptidase activity + +[Term] +id: GO:0071973 +name: bacterial-type flagellum-dependent cell motility +namespace: biological_process +def: "Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:krc, GOC:mah] +subset: goslim_metagenomics +synonym: "bacterial-type flagellar cell motility" RELATED [] +synonym: "flagellin-based flagellar cell motility" EXACT [GOC:mah] +is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:0071975 +name: cell swimming +namespace: biological_process +def: "Cell motility that results in the smooth movement of a cell through a liquid medium." [PMID:18461074] +synonym: "cell swimming motility" EXACT [GOC:mah] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0071976 +name: cell gliding +namespace: biological_process +def: "Cell motility that results in the smooth movement of a cell along a solid surface." [PMID:18461074] +synonym: "cell gliding motility" EXACT [GOC:mah] +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0071977 +name: bacterial-type flagellum-dependent swimming motility +namespace: biological_process +def: "Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium." [GOC:cilia, PMID:18461074] +synonym: "bacterial-type flagellar swimming motility" RELATED [] +synonym: "bacterial-type flagellum-mediated cell swimming" EXACT [GOC:mah] +is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility +is_a: GO:0071975 ! cell swimming + +[Term] +id: GO:0071978 +name: bacterial-type flagellum-dependent swarming motility +namespace: biological_process +def: "Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria." [GOC:cilia, PMID:14527279, PMID:18461074] +synonym: "bacterial-type flagellar swarming motility" RELATED [] +synonym: "bacterial-type flagellum-mediated cell swarming" EXACT [GOC:mah] +is_a: GO:0071973 ! bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:0071979 +name: cytoskeleton-mediated cell swimming +namespace: biological_process +def: "Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium." [PMID:18461074] +synonym: "cytoskeleton-mediated swimming motility" EXACT [GOC:mah] +is_a: GO:0071975 ! cell swimming + +[Term] +id: GO:0071980 +name: cell surface adhesin-mediated gliding motility +namespace: biological_process +def: "Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." [PMID:18461074] +is_a: GO:0071976 ! cell gliding + +[Term] +id: GO:0071981 +name: exit from diapause +namespace: biological_process +def: "The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0071982 +name: maintenance of diapause +namespace: biological_process +def: "The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation." [GOC:mah] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0071983 +name: exit from reproductive diapause +namespace: biological_process +def: "The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] +is_a: GO:0071981 ! exit from diapause + +[Term] +id: GO:0071984 +name: maintenance of reproductive diapause +namespace: biological_process +def: "The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli." [GOC:mah] +is_a: GO:0071982 ! maintenance of diapause + +[Term] +id: GO:0071985 +name: multivesicular body sorting pathway +namespace: biological_process +def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0071986 +name: Ragulator complex +namespace: cellular_component +alt_id: GO:0034448 +alt_id: GO:0034449 +def: "A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signalling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified)." [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950] +synonym: "EGO complex" RELATED [] +synonym: "EGO-GSE complex" RELATED [] +synonym: "GSE complex" RELATED [] +synonym: "GTPase-containing complex for Gap1p sorting in the endosome" RELATED [] +synonym: "MAPKSP1/ROBLD3/C11orf59 complex" EXACT [GOC:mah] +synonym: "Rag GEF" EXACT [] +is_a: GO:0032045 ! guanyl-nucleotide exchange factor complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005774 ! vacuolar membrane +relationship: part_of GO:0031902 ! late endosome membrane +relationship: part_of GO:0045121 ! membrane raft + +[Term] +id: GO:0071987 +name: WD40-repeat domain binding +namespace: molecular_function +def: "Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain." [GOC:yaf, InterPro:IPR017986] +synonym: "beta-transducin repeat domain binding" EXACT [GOC:yaf] +synonym: "WD domain binding" EXACT [GOC:yaf] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0071988 +name: protein localization to spindle pole body +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah] +synonym: "protein localisation to spindle pole body" EXACT [GOC:mah] +is_a: GO:1905508 ! protein localization to microtubule organizing center + +[Term] +id: GO:0071989 +name: establishment of protein localization to spindle pole body +namespace: biological_process +def: "The directed movement of a protein to a specific location at the spindle pole body." [GOC:mah] +synonym: "establishment of protein localisation to spindle pole body" EXACT [GOC:mah] +is_a: GO:0071988 ! protein localization to spindle pole body +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0071990 +name: maintenance of protein location to spindle pole body +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere." [GOC:mah, GOC:vw] +synonym: "maintenance of protein location at spindle pole body" EXACT [] +synonym: "maintenance of protein location in spindle pole body" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0051300 ! spindle pole body organization +relationship: part_of GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:0071993 +name: phytochelatin transport +namespace: biological_process +def: "The directed movement of a phytochelatin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] +synonym: "cadystin transport" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:0071994 +name: phytochelatin transmembrane transport +namespace: biological_process +def: "The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "cadystin transmembrane transport" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "phytochelatin membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071993 ! phytochelatin transport + +[Term] +id: GO:0071995 +name: phytochelatin import into vacuole +namespace: biological_process +def: "The directed movement of phytochelatins into the vacuole. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes." [GOC:mah, ISBN:0198506732] +synonym: "cadystin import into vacuole" RELATED [GOC:vw, Wikipedia:Phytochelatin#History] +synonym: "phytochelatin transport into vacuole" EXACT [GOC:vw] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0071994 ! phytochelatin transmembrane transport + +[Term] +id: GO:0071996 +name: glutathione transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of glutathione into the vacuole across the vacuolar membrane." [GOC:mah] +synonym: "glutathione transport into vacuole" EXACT [GOC:vw] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0034775 ! glutathione transmembrane transport + +[Term] +id: GO:0071998 +name: ascospore release from ascus +namespace: biological_process +def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah] +synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048869 ! cellular developmental process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0071999 +name: extracellular polysaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw] +synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah] +synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah] +synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah] +is_a: GO:0044247 ! cellular polysaccharide catabolic process +is_a: GO:0046379 ! extracellular polysaccharide metabolic process + +[Term] +id: GO:0072000 +name: extracellular polysaccharide catabolic process involved in ascospore release from ascus +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah, GOC:vw] +synonym: "ascus catabolic process" RELATED [GOC:vw] +synonym: "ascus endolysis" RELATED [GOC:vw] +synonym: "extracellular polysaccharide breakdown involved in ascospore release from ascus" EXACT [GOC:mah] +synonym: "extracellular polysaccharide catabolism involved in ascospore release from ascus" EXACT [GOC:mah] +synonym: "extracellular polysaccharide degradation involved in ascospore release from ascus" EXACT [GOC:mah] +is_a: GO:0071999 ! extracellular polysaccharide catabolic process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0071998 ! ascospore release from ascus + +[Term] +id: GO:0072001 +name: renal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels." [GOC:mtg_kidney_jan10, GOC:yaf, http://en.wikibooks.org/wiki/Human_Physiology/The_Urinary_System] +subset: gocheck_do_not_annotate +synonym: "urinary system development" BROAD [GOC:yaf] +synonym: "urinary tract development" BROAD [GOC:yaf, PMID:17881463] +is_a: GO:0048731 ! system development +relationship: part_of GO:0001655 ! urogenital system development + +[Term] +id: GO:0072002 +name: Malpighian tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [FBbt:00005786, GOC:mtg_kidney_jan10, PMID:19783135] +is_a: GO:0048513 ! animal organ development +is_a: GO:0061326 ! renal tubule development + +[Term] +id: GO:0072003 +name: kidney rudiment formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +synonym: "kidney anlage formation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060993 ! kidney morphogenesis + +[Term] +id: GO:0072004 +name: kidney field specification +namespace: biological_process +def: "The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop." [GOC:mtg_kidney_jan10] +synonym: "specification of kidney anlage" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0010092 ! specification of animal organ identity +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0072003 ! kidney rudiment formation + +[Term] +id: GO:0072005 +name: maintenance of kidney identity +namespace: biological_process +def: "The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] +synonym: "maintenance of kidney anlage identity" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0048496 ! maintenance of animal organ identity +relationship: part_of GO:0072003 ! kidney rudiment formation + +[Term] +id: GO:0072006 +name: nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] +synonym: "nephrogenesis" RELATED [GOC:rph] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072007 +name: mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +is_a: GO:1904238 ! pericyte cell differentiation + +[Term] +id: GO:0072008 +name: glomerular mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +is_a: GO:0072007 ! mesangial cell differentiation +relationship: part_of GO:0072109 ! glomerular mesangium development + +[Term] +id: GO:0072009 +name: nephron epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0072073 ! kidney epithelium development +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0072010 +name: glomerular epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +relationship: part_of GO:0032835 ! glomerulus development + +[Term] +id: GO:0072011 +name: glomerular endothelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0003158 ! endothelium development +is_a: GO:0072010 ! glomerular epithelium development +relationship: part_of GO:0072012 ! glomerulus vasculature development + +[Term] +id: GO:0072012 +name: glomerulus vasculature development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] +synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0001568 ! blood vessel development +is_a: GO:0061440 ! kidney vasculature development +relationship: part_of GO:0032835 ! glomerulus development + +[Term] +id: GO:0072013 +name: glomus development +namespace: biological_process +def: "The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment." [GOC:mtg_kidney_jan10, PMID:10572058, PMID:15647339, PMID:9268568, XAO:0000318] +synonym: "pronephric glomus development" EXACT [GOC:mtg_kidney_jan10, PMID:15895368] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0072014 +name: proximal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072015 +name: glomerular visceral epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] +synonym: "podocyte development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072310 ! glomerular epithelial cell development +relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0072016 +name: glomerular parietal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +synonym: "Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072310 ! glomerular epithelial cell development +relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0072017 +name: distal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072019 +name: proximal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0072014 ! proximal tubule development + +[Term] +id: GO:0072020 +name: proximal straight tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule." [GOC:mtg_kidney_jan10] +synonym: "S3 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0072014 ! proximal tubule development + +[Term] +id: GO:0072021 +name: ascending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0072070 ! loop of Henle development + +[Term] +id: GO:0072022 +name: descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0072070 ! loop of Henle development + +[Term] +id: GO:0072023 +name: thick ascending limb development +namespace: biological_process +alt_id: GO:0072026 +def: "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] +synonym: "TAL development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0072017 ! distal tubule development + +[Term] +id: GO:0072024 +name: macula densa development +namespace: biological_process +def: "The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +relationship: part_of GO:0072051 ! juxtaglomerular apparatus development + +[Term] +id: GO:0072025 +name: distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +relationship: part_of GO:0072017 ! distal tubule development + +[Term] +id: GO:0072027 +name: connecting tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct." [GOC:mtg_kidney_jan10] +synonym: "connecting duct development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072028 +name: nephron morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060993 ! kidney morphogenesis +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0072029 +name: long nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla." [GOC:mtg_kidney_jan10] +synonym: "juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072006 ! nephron development + +[Term] +id: GO:0072030 +name: short nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] +is_a: GO:0072006 ! nephron development + +[Term] +id: GO:0072031 +name: proximal convoluted tubule segment 1 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:mtg_kidney_jan10, MA:0002612] +synonym: "S1 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0072019 ! proximal convoluted tubule development + +[Term] +id: GO:0072032 +name: proximal convoluted tubule segment 2 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride." [GOC:mtg_kidney_jan10, MA:0002613] +synonym: "S2 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0072019 ! proximal convoluted tubule development + +[Term] +id: GO:0072033 +name: renal vesicle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] +synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0072077 ! renal vesicle morphogenesis + +[Term] +id: GO:0072034 +name: renal vesicle induction +namespace: biological_process +def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle." [GOC:mtg_kidney_jan10] +synonym: "nephron induction" EXACT [GOC:mtg_kidney_jan10] +synonym: "positive regulation of nephron formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0031128 ! developmental induction +is_a: GO:0090184 ! positive regulation of kidney development +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0072033 ! renal vesicle formation + +[Term] +id: GO:0072035 +name: pre-tubular aggregate formation +namespace: biological_process +def: "The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] +synonym: "mesenchymal cell condensation involved in renal vesicle formation" EXACT [GOC:mtg_kidney_jan10] +synonym: "nephron epithelium formation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0072033 ! renal vesicle formation + +[Term] +id: GO:0072036 +name: mesenchymal to epithelial transition involved in renal vesicle formation +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the renal vesicle." [GOC:mtg_kidney_jan10] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +is_a: GO:0060231 ! mesenchymal to epithelial transition +relationship: part_of GO:0072033 ! renal vesicle formation + +[Term] +id: GO:0072037 +name: mesenchymal stem cell differentiation involved in nephron morphogenesis +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +is_a: GO:0072497 ! mesenchymal stem cell differentiation +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072038 +name: mesenchymal stem cell maintenance involved in nephron morphogenesis +namespace: biological_process +def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0035019 ! somatic stem cell population maintenance +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072039 +name: regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] +synonym: "regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] +is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis +is_a: GO:1904672 ! regulation of somatic stem cell population maintenance +is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process +relationship: regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis +relationship: regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis + +[Term] +id: GO:0072040 +name: negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +namespace: biological_process +def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] +synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] +is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis +is_a: GO:1904673 ! negative regulation of somatic stem cell population maintenance +is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process +relationship: negatively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis +relationship: negatively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis + +[Term] +id: GO:0072041 +name: positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +namespace: biological_process +def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis" NARROW [] +synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis" EXACT [] +is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis +is_a: GO:1904674 ! positive regulation of somatic stem cell population maintenance +is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process +relationship: positively_regulates GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis +relationship: positively_regulates GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis + +[Term] +id: GO:0072042 +name: regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] +is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation +relationship: regulates GO:0072090 ! mesenchymal stem cell proliferation involved in nephron morphogenesis + +[Term] +id: GO:0072043 +name: regulation of pre-tubular aggregate formation by cell-cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney." [GOC:mtg_kidney_jan10] +synonym: "regulation of pre-tubular aggregate formation by cell-cell signalling" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0072035 ! pre-tubular aggregate formation + +[Term] +id: GO:0072044 +name: collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072045 +name: convergent extension involved in nephron morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0060029 ! convergent extension involved in organogenesis +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072046 +name: establishment of planar polarity involved in nephron morphogenesis +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] +synonym: "establishment of planar cell polarity involved in nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] +is_a: GO:0001736 ! establishment of planar polarity +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072047 +name: proximal/distal pattern formation involved in nephron development +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] +synonym: "proximal-distal pattern formation involved in nephron development" EXACT [GOC:mtg_kidney_jan10] +synonym: "proximal/distal nephron patterning" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0009954 ! proximal/distal pattern formation +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0072048 +name: renal system pattern specification +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system." [GOC:mtg_kidney_jan10] +synonym: "renal system pattern formation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0072049 +name: comma-shaped body morphogenesis +namespace: biological_process +def: "The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072050 +name: S-shaped body morphogenesis +namespace: biological_process +def: "The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072051 +name: juxtaglomerular apparatus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072052 +name: juxtaglomerulus cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0072051 ! juxtaglomerular apparatus development + +[Term] +id: GO:0072053 +name: renal inner medulla development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney." [GOC:mtg_kidney_jan10] +synonym: "inner renal medulla development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072054 +name: renal outer medulla development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla." [GOC:mtg_kidney_jan10] +synonym: "outer renal medulla development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072055 +name: renal cortex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072056 +name: pyramid development +namespace: biological_process +def: "The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] +synonym: "kidney pyramid development" EXACT [GOC:mah] +synonym: "pyramids development" EXACT [GOC:mah] +synonym: "renal medulla development" EXACT [GOC:mah] +synonym: "renal pyramid development" EXACT [GOC:mah] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072057 +name: inner stripe development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0072054 ! renal outer medulla development + +[Term] +id: GO:0072058 +name: outer stripe development +namespace: biological_process +def: "The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0072054 ! renal outer medulla development + +[Term] +id: GO:0072059 +name: cortical collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0072060 +name: outer medullary collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla." [GOC:mtg_kidney_jan10] +is_a: GO:0072044 ! collecting duct development + +[Term] +id: GO:0072061 +name: inner medullary collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla." [GOC:mtg_kidney_jan10] +is_a: GO:0072044 ! collecting duct development + +[Term] +id: GO:0072062 +name: proximal convoluted tubule segment 1 cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "S1 cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0072031 ! proximal convoluted tubule segment 1 development + +[Term] +id: GO:0072063 +name: short descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +is_a: GO:0072022 ! descending thin limb development +relationship: part_of GO:0072030 ! short nephron development + +[Term] +id: GO:0072064 +name: long descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +is_a: GO:0072022 ! descending thin limb development +relationship: part_of GO:0072029 ! long nephron development + +[Term] +id: GO:0072065 +name: long descending thin limb bend development +namespace: biological_process +def: "The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0072064 ! long descending thin limb development + +[Term] +id: GO:0072066 +name: prebend segment development +namespace: biological_process +def: "The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +relationship: part_of GO:0072022 ! descending thin limb development + +[Term] +id: GO:0072067 +name: early distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +relationship: part_of GO:0072025 ! distal convoluted tubule development + +[Term] +id: GO:0072068 +name: late distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +relationship: part_of GO:0072025 ! distal convoluted tubule development + +[Term] +id: GO:0072069 +name: DCT cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0072025 ! distal convoluted tubule development + +[Term] +id: GO:0072070 +name: loop of Henle development +namespace: biological_process +alt_id: GO:0072018 +def: "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule." [GOC:mtg_kidney_jan10] +synonym: "intermediate tubule development" EXACT [] +is_a: GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072071 +name: kidney interstitial fibroblast differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "kidney interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development + +[Term] +id: GO:0072072 +name: kidney stroma development +namespace: biological_process +def: "The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0061448 ! connective tissue development +is_a: GO:0072074 ! kidney mesenchyme development + +[Term] +id: GO:0072073 +name: kidney epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072074 +name: kidney mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0060485 ! mesenchyme development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072075 +name: metanephric mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072074 ! kidney mesenchyme development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072076 +name: nephrogenic mesenchyme development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0072074 ! kidney mesenchyme development +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0072077 +name: renal vesicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0072087 ! renal vesicle development +relationship: part_of GO:0072088 ! nephron epithelium morphogenesis + +[Term] +id: GO:0072078 +name: nephron tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0061333 ! renal tubule morphogenesis +is_a: GO:0072088 ! nephron epithelium morphogenesis +relationship: part_of GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072079 +name: nephron tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0001838 ! embryonic epithelial tube formation +relationship: part_of GO:0072078 ! nephron tubule morphogenesis + +[Term] +id: GO:0072080 +name: nephron tubule development +namespace: biological_process +def: "The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0061326 ! renal tubule development +is_a: GO:0072009 ! nephron epithelium development + +[Term] +id: GO:0072081 +name: specification of nephron tubule identity +namespace: biological_process +def: "The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0007379 ! segment specification +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0072047 ! proximal/distal pattern formation involved in nephron development +relationship: part_of GO:0072079 ! nephron tubule formation + +[Term] +id: GO:0072082 +name: specification of proximal tubule identity +namespace: biological_process +def: "The process in which the proximal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0072158 ! proximal tubule morphogenesis + +[Term] +id: GO:0072084 +name: specification of distal tubule identity +namespace: biological_process +def: "The process in which the distal tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0072156 ! distal tubule morphogenesis + +[Term] +id: GO:0072085 +name: specification of connecting tubule identity +namespace: biological_process +def: "The process in which the connecting tubule of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0072027 ! connecting tubule development + +[Term] +id: GO:0072086 +name: specification of loop of Henle identity +namespace: biological_process +alt_id: GO:0072083 +def: "The process in which the loop of Henle of the kidney nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "specification of intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0072070 ! loop of Henle development + +[Term] +id: GO:0072087 +name: renal vesicle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072073 ! kidney epithelium development +relationship: part_of GO:0072009 ! nephron epithelium development + +[Term] +id: GO:0072088 +name: nephron epithelium morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0072009 ! nephron epithelium development +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:0072089 +name: stem cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0072090 +name: mesenchymal stem cell proliferation involved in nephron morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0097168 ! mesenchymal stem cell proliferation + +[Term] +id: GO:0072091 +name: regulation of stem cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [GOC:mtg_kidney_jan10] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0072089 ! stem cell proliferation + +[Term] +id: GO:0072092 +name: ureteric bud invasion +namespace: biological_process +def: "The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0060677 ! ureteric bud elongation +relationship: part_of GO:0072093 ! metanephric renal vesicle formation + +[Term] +id: GO:0072093 +name: metanephric renal vesicle formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephros formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072033 ! renal vesicle formation +relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis + +[Term] +id: GO:0072094 +name: metanephric renal vesicle induction +namespace: biological_process +def: "Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] +synonym: "positive regulation of metanephros formation" BROAD [GOC:mtg_kidney_jan10] +is_a: GO:0072034 ! renal vesicle induction +is_a: GO:0072216 ! positive regulation of metanephros development +relationship: positively_regulates GO:0072093 ! metanephric renal vesicle formation + +[Term] +id: GO:0072095 +name: regulation of branch elongation involved in ureteric bud branching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0060681 ! branch elongation involved in ureteric bud branching + +[Term] +id: GO:0072096 +name: negative regulation of branch elongation involved in ureteric bud branching +namespace: biological_process +def: "Any process that reduces the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0072095 ! regulation of branch elongation involved in ureteric bud branching +relationship: negatively_regulates GO:0060681 ! branch elongation involved in ureteric bud branching + +[Term] +id: GO:0072097 +name: negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the reduction of the frequency, rate or extent of branch elongation involved in ureteric bud branching, the growth of a branch of the ureteric bud along its axis." [GOC:mtg_kidney_jan10] +synonym: "negative regulation of branch elongation involved in ureteric bud branching by BMP signalling pathway" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +is_a: GO:0072096 ! negative regulation of branch elongation involved in ureteric bud branching + +[Term] +id: GO:0072098 +name: anterior/posterior pattern specification involved in kidney development +namespace: biological_process +def: "The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] +synonym: "anterior/posterior pattern formation involved in kidney development" RELATED [GOC:mtg_kidney_jan10] +synonym: "kidney anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] +synonym: "kidney anterior/posterior pattern specification" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0009952 ! anterior/posterior pattern specification +is_a: GO:0061004 ! pattern specification involved in kidney development + +[Term] +id: GO:0072099 +name: anterior/posterior pattern specification involved in ureteric bud development +namespace: biological_process +def: "The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] +synonym: "ureteric bud anterior/posterior pattern formation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0061227 ! pattern specification involved in mesonephros development +is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development +relationship: part_of GO:0001657 ! ureteric bud development + +[Term] +id: GO:0072100 +name: specification of ureteric bud anterior/posterior symmetry +namespace: biological_process +def: "The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] +synonym: "specification of ureteric bud anterior/posterior asymmetry" EXACT [GOC:dph] +is_a: GO:0009799 ! specification of symmetry +is_a: GO:0072099 ! anterior/posterior pattern specification involved in ureteric bud development + +[Term] +id: GO:0072101 +name: specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway +namespace: biological_process +def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis." [GOC:mtg_kidney_jan10] +synonym: "specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway" EXACT [GOC:dph] +synonym: "specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway" EXACT [GOC:mah] +is_a: GO:0030509 ! BMP signaling pathway +is_a: GO:0072100 ! specification of ureteric bud anterior/posterior symmetry + +[Term] +id: GO:0072102 +name: glomerulus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0032835 ! glomerulus development + +[Term] +id: GO:0072103 +name: glomerulus vasculature morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0048514 ! blood vessel morphogenesis +is_a: GO:0061439 ! kidney vasculature morphogenesis +relationship: part_of GO:0072012 ! glomerulus vasculature development +relationship: part_of GO:0072102 ! glomerulus morphogenesis + +[Term] +id: GO:0072104 +name: glomerular capillary formation +namespace: biological_process +def: "The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] +is_a: GO:0001525 ! angiogenesis +relationship: part_of GO:0072103 ! glomerulus vasculature morphogenesis + +[Term] +id: GO:0072105 +name: ureteric peristalsis +namespace: biological_process +def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_kidney_jan10] +is_a: GO:0014849 ! ureter smooth muscle contraction +is_a: GO:0030432 ! peristalsis + +[Term] +id: GO:0072106 +name: regulation of ureteric bud formation +namespace: biological_process +def: "Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] +is_a: GO:0061217 ! regulation of mesonephros development +is_a: GO:1905276 ! regulation of epithelial tube formation +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0060676 ! ureteric bud formation + +[Term] +id: GO:0072107 +name: positive regulation of ureteric bud formation +namespace: biological_process +def: "Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10] +is_a: GO:0072106 ! regulation of ureteric bud formation +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +is_a: GO:1905278 ! positive regulation of epithelial tube formation +relationship: positively_regulates GO:0060676 ! ureteric bud formation + +[Term] +id: GO:0072108 +name: positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development +relationship: positively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis + +[Term] +id: GO:0072109 +name: glomerular mesangium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0072012 ! glomerulus vasculature development + +[Term] +id: GO:0072110 +name: glomerular mesangial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0072109 ! glomerular mesangium development + +[Term] +id: GO:0072111 +name: cell proliferation involved in kidney development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072112 +name: glomerular visceral epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] +synonym: "podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0061318 ! renal filtration cell differentiation +is_a: GO:0072311 ! glomerular epithelial cell differentiation + +[Term] +id: GO:0072113 +name: head kidney development +namespace: biological_process +def: "The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis." [GOC:mtg_kidney_jan10, ZFA:0000669] +is_a: GO:0048534 ! hematopoietic or lymphoid organ development +is_a: GO:0048793 ! pronephros development + +[Term] +id: GO:0072114 +name: pronephros morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] +synonym: "pronephric kidney morphogenesis" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0060993 ! kidney morphogenesis +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0072115 +name: head kidney morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] +is_a: GO:0072114 ! pronephros morphogenesis +relationship: part_of GO:0072113 ! head kidney development + +[Term] +id: GO:0072116 +name: pronephros formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] +synonym: "pronephric kidney formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048645 ! animal organ formation +is_a: GO:0072003 ! kidney rudiment formation +relationship: part_of GO:0072114 ! pronephros morphogenesis + +[Term] +id: GO:0072117 +name: head kidney formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] +is_a: GO:0072116 ! pronephros formation +relationship: part_of GO:0072115 ! head kidney morphogenesis + +[Term] +id: GO:0072118 +name: pronephros structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] +synonym: "pronephric kidney structural organization" EXACT [GOC:mtg_kidney_jan10] +synonym: "pronephros structural organisation" EXACT [GOC:mah] +is_a: GO:0048532 ! anatomical structure arrangement +relationship: part_of GO:0072114 ! pronephros morphogenesis + +[Term] +id: GO:0072119 +name: head kidney structural organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] +synonym: "head kidney structural organisation" EXACT [GOC:mah] +is_a: GO:0072118 ! pronephros structural organization +relationship: part_of GO:0072115 ! head kidney morphogenesis + +[Term] +id: GO:0072120 +name: pronephros maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:mtg_kidney_jan10] +synonym: "pronephric kidney maturation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048799 ! animal organ maturation +relationship: part_of GO:0048793 ! pronephros development + +[Term] +id: GO:0072121 +name: head kidney maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney." [GOC:mtg_kidney_jan10, ZFA:0000669] +is_a: GO:0072120 ! pronephros maturation +relationship: part_of GO:0072113 ! head kidney development + +[Term] +id: GO:0072122 +name: extraglomerular mesangial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] +synonym: "Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0072006 ! nephron development + +[Term] +id: GO:0072123 +name: intraglomerular mesangial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] +is_a: GO:0072110 ! glomerular mesangial cell proliferation + +[Term] +id: GO:0072124 +name: regulation of glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development +relationship: regulates GO:0072110 ! glomerular mesangial cell proliferation + +[Term] +id: GO:0072125 +name: negative regulation of glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation +is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development +relationship: negatively_regulates GO:0072110 ! glomerular mesangial cell proliferation + +[Term] +id: GO:0072126 +name: positive regulation of glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation +is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development +relationship: positively_regulates GO:0072110 ! glomerular mesangial cell proliferation + +[Term] +id: GO:0072127 +name: renal capsule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] +is_a: GO:0061448 ! connective tissue development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072128 +name: renal capsule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0072127 ! renal capsule development + +[Term] +id: GO:0072129 +name: renal capsule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands." [GOC:mtg_kidney_jan10] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0072128 ! renal capsule morphogenesis + +[Term] +id: GO:0072130 +name: renal capsule specification +namespace: biological_process +def: "The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] +is_a: GO:0003002 ! regionalization +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0072129 ! renal capsule formation + +[Term] +id: GO:0072131 +name: kidney mesenchyme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0072132 ! mesenchyme morphogenesis +relationship: part_of GO:0072074 ! kidney mesenchyme development + +[Term] +id: GO:0072132 +name: mesenchyme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells." [GOC:mtg_kidney_jan10] +is_a: GO:0048729 ! tissue morphogenesis +relationship: part_of GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0060485 ! mesenchyme development + +[Term] +id: GO:0072133 +name: metanephric mesenchyme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072131 ! kidney mesenchyme morphogenesis +relationship: part_of GO:0072075 ! metanephric mesenchyme development + +[Term] +id: GO:0072134 +name: nephrogenic mesenchyme morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron." [GOC:mtg_kidney_jan10] +is_a: GO:0072131 ! kidney mesenchyme morphogenesis +relationship: part_of GO:0072076 ! nephrogenic mesenchyme development + +[Term] +id: GO:0072135 +name: kidney mesenchymal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0010463 ! mesenchymal cell proliferation +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0072074 ! kidney mesenchyme development + +[Term] +id: GO:0072136 +name: metanephric mesenchymal cell proliferation involved in metanephros development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population." [GOC:mtg_kidney_jan10] +is_a: GO:0072135 ! kidney mesenchymal cell proliferation +is_a: GO:0072203 ! cell proliferation involved in metanephros development +relationship: part_of GO:0072075 ! metanephric mesenchyme development + +[Term] +id: GO:0072137 +name: condensed mesenchymal cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0072138 +name: mesenchymal cell proliferation involved in ureteric bud development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureteric bud, that contributes to ureteric bud development." [GOC:mtg_kidney_jan10] +synonym: "ureteric bud mesenchymal cell proliferation" BROAD [GOC:mtg_kidney_jan10] +is_a: GO:0010463 ! mesenchymal cell proliferation +is_a: GO:0061209 ! cell proliferation involved in mesonephros development +relationship: part_of GO:0001657 ! ureteric bud development + +[Term] +id: GO:0072139 +name: glomerular parietal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +is_a: GO:0072311 ! glomerular epithelial cell differentiation + +[Term] +id: GO:0072140 +name: DCT cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +synonym: "distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0072069 ! DCT cell differentiation + +[Term] +id: GO:0072141 +name: renal interstitial fibroblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +synonym: "kidney interstitial cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation + +[Term] +id: GO:0072142 +name: juxtaglomerulus cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation + +[Term] +id: GO:0072143 +name: mesangial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0072007 ! mesangial cell differentiation + +[Term] +id: GO:0072144 +name: glomerular mesangial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0002064 ! epithelial cell development +is_a: GO:0072143 ! mesangial cell development +relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation + +[Term] +id: GO:0072145 +name: proximal convoluted tubule segment 1 cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "S1 cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation + +[Term] +id: GO:0072146 +name: DCT cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell." [GOC:mtg_kidney_jan10] +synonym: "distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0072069 ! DCT cell differentiation + +[Term] +id: GO:0072147 +name: glomerular parietal epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] +synonym: "Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072148 ! epithelial cell fate commitment +is_a: GO:0072314 ! glomerular epithelial cell fate commitment +relationship: part_of GO:0072139 ! glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0072148 +name: epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell." [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:0072149 +name: glomerular visceral epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells." [GOC:mtg_kidney_jan10] +synonym: "podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072148 ! epithelial cell fate commitment +is_a: GO:0072314 ! glomerular epithelial cell fate commitment +relationship: part_of GO:0072112 ! glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0072150 +name: juxtaglomerulus cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell." [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0072052 ! juxtaglomerulus cell differentiation + +[Term] +id: GO:0072151 +name: mesangial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell." [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0072007 ! mesangial cell differentiation + +[Term] +id: GO:0072152 +name: glomerular mesangial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell." [GOC:mtg_kidney_jan10] +is_a: GO:0072151 ! mesangial cell fate commitment +relationship: part_of GO:0072008 ! glomerular mesangial cell differentiation + +[Term] +id: GO:0072153 +name: renal interstitial fibroblast fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast." [GOC:mtg_kidney_jan10] +synonym: "kidney interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0072071 ! kidney interstitial fibroblast differentiation + +[Term] +id: GO:0072154 +name: proximal convoluted tubule segment 1 cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "S1 cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0072062 ! proximal convoluted tubule segment 1 cell differentiation + +[Term] +id: GO:0072155 +name: epithelial cell migration involved in nephron tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0010631 ! epithelial cell migration +is_a: GO:0035787 ! cell migration involved in kidney development +relationship: part_of GO:0072078 ! nephron tubule morphogenesis + +[Term] +id: GO:0072156 +name: distal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072078 ! nephron tubule morphogenesis +relationship: part_of GO:0072017 ! distal tubule development + +[Term] +id: GO:0072157 +name: epithelial cell migration involved in distal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis +relationship: part_of GO:0072156 ! distal tubule morphogenesis + +[Term] +id: GO:0072158 +name: proximal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072078 ! nephron tubule morphogenesis +relationship: part_of GO:0072014 ! proximal tubule development + +[Term] +id: GO:0072159 +name: epithelial cell migration involved in proximal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis +relationship: part_of GO:0072158 ! proximal tubule morphogenesis + +[Term] +id: GO:0072160 +name: nephron tubule epithelial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +relationship: part_of GO:0072080 ! nephron tubule development + +[Term] +id: GO:0072161 +name: mesenchymal cell differentiation involved in kidney development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +is_a: GO:2001012 ! mesenchymal cell differentiation involved in renal system development +relationship: part_of GO:0072074 ! kidney mesenchyme development + +[Term] +id: GO:0072162 +name: metanephric mesenchymal cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0072161 ! mesenchymal cell differentiation involved in kidney development +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072075 ! metanephric mesenchyme development + +[Term] +id: GO:0072163 +name: mesonephric epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072073 ! kidney epithelium development +relationship: part_of GO:0001823 ! mesonephros development + +[Term] +id: GO:0072164 +name: mesonephric tubule development +namespace: biological_process +def: "The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +is_a: GO:0072163 ! mesonephric epithelium development + +[Term] +id: GO:0072165 +name: anterior mesonephric tubule development +namespace: biological_process +def: "The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072164 ! mesonephric tubule development + +[Term] +id: GO:0072166 +name: posterior mesonephric tubule development +namespace: biological_process +def: "The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072164 ! mesonephric tubule development + +[Term] +id: GO:0072167 +name: specification of mesonephric tubule identity +namespace: biological_process +def: "The process in which the tubules of the mesonephros acquire their identity." [GOC:mtg_kidney_jan10] +is_a: GO:0061227 ! pattern specification involved in mesonephros development +is_a: GO:0072081 ! specification of nephron tubule identity +relationship: part_of GO:0072172 ! mesonephric tubule formation + +[Term] +id: GO:0072168 +name: specification of anterior mesonephric tubule identity +namespace: biological_process +def: "The process in which the tubules of the anterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] +is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development +is_a: GO:0072167 ! specification of mesonephric tubule identity +relationship: part_of GO:0072165 ! anterior mesonephric tubule development + +[Term] +id: GO:0072169 +name: specification of posterior mesonephric tubule identity +namespace: biological_process +def: "The process in which the tubules of the posterior mesonephros acquire their identity." [GOC:mtg_kidney_jan10] +is_a: GO:0072098 ! anterior/posterior pattern specification involved in kidney development +is_a: GO:0072167 ! specification of mesonephric tubule identity +relationship: part_of GO:0072166 ! posterior mesonephric tubule development + +[Term] +id: GO:0072170 +name: metanephric tubule development +namespace: biological_process +def: "The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +is_a: GO:0072207 ! metanephric epithelium development + +[Term] +id: GO:0072171 +name: mesonephric tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072078 ! nephron tubule morphogenesis +relationship: part_of GO:0072164 ! mesonephric tubule development + +[Term] +id: GO:0072172 +name: mesonephric tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072079 ! nephron tubule formation +relationship: part_of GO:0072171 ! mesonephric tubule morphogenesis + +[Term] +id: GO:0072173 +name: metanephric tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0072170 ! metanephric tubule development + +[Term] +id: GO:0072174 +name: metanephric tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a metanephric tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0072173 ! metanephric tubule morphogenesis + +[Term] +id: GO:0072175 +name: epithelial tube formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of an epithelial tube." [GOC:mtg_kidney_jan10] +is_a: GO:0035148 ! tube formation +relationship: part_of GO:0060562 ! epithelial tube morphogenesis + +[Term] +id: GO:0072176 +name: nephric duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0035295 ! tube development +is_a: GO:0072073 ! kidney epithelium development + +[Term] +id: GO:0072177 +name: mesonephric duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "Wolffian duct development" EXACT [GOC:dph] +is_a: GO:0072164 ! mesonephric tubule development +is_a: GO:0072176 ! nephric duct development + +[Term] +id: GO:0072178 +name: nephric duct morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0060562 ! epithelial tube morphogenesis +relationship: part_of GO:0072176 ! nephric duct development + +[Term] +id: GO:0072179 +name: nephric duct formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0072175 ! epithelial tube formation +relationship: part_of GO:0072178 ! nephric duct morphogenesis + +[Term] +id: GO:0072180 +name: mesonephric duct morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "Wolffian duct morphogenesis" RELATED [GOC:dph] +is_a: GO:0072171 ! mesonephric tubule morphogenesis +is_a: GO:0072178 ! nephric duct morphogenesis +relationship: part_of GO:0072177 ! mesonephric duct development + +[Term] +id: GO:0072181 +name: mesonephric duct formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros." [GOC:mtg_kidney_jan10] +synonym: "Wolffian duct formation" EXACT [GOC:dph] +is_a: GO:0072172 ! mesonephric tubule formation +is_a: GO:0072179 ! nephric duct formation +is_a: GO:0072180 ! mesonephric duct morphogenesis + +[Term] +id: GO:0072182 +name: regulation of nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development +relationship: regulates GO:0072160 ! nephron tubule epithelial cell differentiation + +[Term] +id: GO:0072183 +name: negative regulation of nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation +is_a: GO:0090185 ! negative regulation of kidney development +is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development +relationship: negatively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation + +[Term] +id: GO:0072184 +name: renal vesicle progenitor cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing." [GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0072087 ! renal vesicle development + +[Term] +id: GO:0072185 +name: metanephric cap development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] +is_a: GO:0072075 ! metanephric mesenchyme development + +[Term] +id: GO:0072186 +name: metanephric cap morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] +is_a: GO:0072133 ! metanephric mesenchyme morphogenesis +relationship: part_of GO:0072185 ! metanephric cap development + +[Term] +id: GO:0072187 +name: metanephric cap formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip." [GOC:mtg_kidney_jan10] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0072186 ! metanephric cap morphogenesis + +[Term] +id: GO:0072188 +name: metanephric cap specification +namespace: biological_process +def: "The process in which the metanephric cap acquires its identity." [GOC:mtg_kidney_jan10] +is_a: GO:0072048 ! renal system pattern specification +is_a: GO:0072187 ! metanephric cap formation +is_a: GO:0072268 ! pattern specification involved in metanephros development + +[Term] +id: GO:0072189 +name: ureter development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut." [GOC:mtg_kidney_jan10] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:0072190 +name: ureter urothelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] +synonym: "ureter epithelium development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0072189 ! ureter development + +[Term] +id: GO:0072191 +name: ureter smooth muscle development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0048745 ! smooth muscle tissue development +relationship: part_of GO:0072189 ! ureter development + +[Term] +id: GO:0072192 +name: ureter epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter." [GOC:mtg_kidney_jan10] +is_a: GO:0030855 ! epithelial cell differentiation +relationship: part_of GO:0072190 ! ureter urothelium development + +[Term] +id: GO:0072193 +name: ureter smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter." [GOC:mtg_kidney_jan10] +is_a: GO:0051145 ! smooth muscle cell differentiation +relationship: part_of GO:0072191 ! ureter smooth muscle development + +[Term] +id: GO:0072194 +name: kidney smooth muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0048745 ! smooth muscle tissue development +relationship: part_of GO:0001822 ! kidney development + +[Term] +id: GO:0072195 +name: kidney smooth muscle cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0051145 ! smooth muscle cell differentiation +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0072194 ! kidney smooth muscle tissue development + +[Term] +id: GO:0072196 +name: proximal/distal pattern formation involved in pronephric nephron development +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros." [GOC:mtg_kidney_jan10] +synonym: "pronephros proximal/distal pattern formation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0039017 ! pattern specification involved in pronephros development +is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development +relationship: part_of GO:0039019 ! pronephric nephron development + +[Term] +id: GO:0072197 +name: ureter morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder." [GOC:mtg_kidney_jan10] +is_a: GO:0009887 ! animal organ morphogenesis +is_a: GO:0035239 ! tube morphogenesis +relationship: part_of GO:0072189 ! ureter development + +[Term] +id: GO:0072198 +name: mesenchymal cell proliferation involved in ureter development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population of the ureter, that contributes to ureter development." [GOC:mtg_kidney_jan10] +synonym: "ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0010463 ! mesenchymal cell proliferation +relationship: part_of GO:0072189 ! ureter development + +[Term] +id: GO:0072199 +name: regulation of mesenchymal cell proliferation involved in ureter development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] +synonym: "regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development + +[Term] +id: GO:0072200 +name: negative regulation of mesenchymal cell proliferation involved in ureter development +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] +synonym: "negative regulation of ureter mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "negative regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development +is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation +relationship: negatively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development + +[Term] +id: GO:0072201 +name: negative regulation of mesenchymal cell proliferation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:mtg_kidney_jan10] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: negatively_regulates GO:0010463 ! mesenchymal cell proliferation + +[Term] +id: GO:0072202 +name: cell differentiation involved in metanephros development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state." [GOC:mah, GOC:mtg_kidney_jan10] +is_a: GO:0061005 ! cell differentiation involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072203 +name: cell proliferation involved in metanephros development +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072111 ! cell proliferation involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072204 +name: cell-cell signaling involved in metanephros development +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the metanephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10] +synonym: "cell-cell signalling involved in metanephros development" EXACT [GOC:mah] +is_a: GO:0060995 ! cell-cell signaling involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072205 +name: metanephric collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder." [GOC:mtg_kidney_jan10] +is_a: GO:0072044 ! collecting duct development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072206 +name: metanephric juxtaglomerular apparatus development +namespace: biological_process +def: "The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate." [GOC:mtg_kidney_jan10] +is_a: GO:0072051 ! juxtaglomerular apparatus development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072207 +name: metanephric epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072073 ! kidney epithelium development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072208 +name: metanephric smooth muscle tissue development +namespace: biological_process +def: "The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072194 ! kidney smooth muscle tissue development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072209 +name: metanephric mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0072007 ! mesangial cell differentiation +is_a: GO:0072202 ! cell differentiation involved in metanephros development + +[Term] +id: GO:0072210 +name: metanephric nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney." [GOC:mtg_kidney_jan10] +is_a: GO:0072006 ! nephron development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072211 +name: metanephric pyramids development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts." [GOC:mtg_kidney_jan10] +synonym: "metanephric kidney pyramid development" EXACT [GOC:mah] +synonym: "metanephric pyramid development" EXACT [GOC:mah] +synonym: "metanephric renal medulla development" EXACT [GOC:mah] +synonym: "metanephric renal pyramid development" EXACT [GOC:mah] +is_a: GO:0072056 ! pyramid development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072212 +name: regulation of transcription from RNA polymerase II promoter involved in metanephros development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the branching morphogenesis by which the metanephros progresses from its initial formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0060994 ! regulation of transcription from RNA polymerase II promoter involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072213 +name: metanephric capsule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] +is_a: GO:0072127 ! renal capsule development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072214 +name: metanephric cortex development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0060485 ! mesenchyme development +is_a: GO:0072055 ! renal cortex development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072215 +name: regulation of metanephros development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0090183 ! regulation of kidney development +relationship: regulates GO:0001656 ! metanephros development + +[Term] +id: GO:0072216 +name: positive regulation of metanephros development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0072215 ! regulation of metanephros development +is_a: GO:0090184 ! positive regulation of kidney development +relationship: positively_regulates GO:0001656 ! metanephros development + +[Term] +id: GO:0072217 +name: negative regulation of metanephros development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:mtg_kidney_jan10] +is_a: GO:0072215 ! regulation of metanephros development +is_a: GO:0090185 ! negative regulation of kidney development +relationship: negatively_regulates GO:0001656 ! metanephros development + +[Term] +id: GO:0072218 +name: metanephric ascending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent." [GOC:mtg_kidney_jan10] +is_a: GO:0072021 ! ascending thin limb development +is_a: GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072236 ! metanephric loop of Henle development + +[Term] +id: GO:0072219 +name: metanephric cortical collecting duct development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex." [GOC:mtg_kidney_jan10] +is_a: GO:0072059 ! cortical collecting duct development + +[Term] +id: GO:0072220 +name: metanephric descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle." [GOC:mtg_kidney_jan10] +is_a: GO:0072022 ! descending thin limb development +relationship: part_of GO:0072236 ! metanephric loop of Henle development + +[Term] +id: GO:0072221 +name: metanephric distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter." [GOC:mtg_kidney_jan10] +is_a: GO:0072025 ! distal convoluted tubule development +is_a: GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072235 ! metanephric distal tubule development + +[Term] +id: GO:0072222 +name: metanephric early distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive." [GOC:mtg_kidney_jan10] +is_a: GO:0072067 ! early distal convoluted tubule development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development + +[Term] +id: GO:0072223 +name: metanephric glomerular mesangium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072109 ! glomerular mesangium development +relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development + +[Term] +id: GO:0072224 +name: metanephric glomerulus development +namespace: biological_process +def: "The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros." [GOC:mah] +synonym: "metanephric glomerular development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0032835 ! glomerulus development +relationship: part_of GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072225 +name: metanephric late distal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive." [GOC:mtg_kidney_jan10] +is_a: GO:0072068 ! late distal convoluted tubule development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development + +[Term] +id: GO:0072226 +name: metanephric long descending thin limb bend development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072065 ! long descending thin limb bend development +relationship: part_of GO:0072220 ! metanephric descending thin limb development +relationship: part_of GO:0072269 ! metanephric long descending thin limb development + +[Term] +id: GO:0072227 +name: metanephric macula densa development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072024 ! macula densa development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development + +[Term] +id: GO:0072228 +name: metanephric prebend segment development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability." [GOC:mtg_kidney_jan10] +is_a: GO:0072066 ! prebend segment development +relationship: part_of GO:0072220 ! metanephric descending thin limb development + +[Term] +id: GO:0072229 +name: metanephric proximal convoluted tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072019 ! proximal convoluted tubule development +is_a: GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072237 ! metanephric proximal tubule development + +[Term] +id: GO:0072230 +name: metanephric proximal straight tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule." [GOC:mtg_kidney_jan10] +synonym: "metanephric S3 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072020 ! proximal straight tubule development +is_a: GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072237 ! metanephric proximal tubule development + +[Term] +id: GO:0072231 +name: metanephric proximal convoluted tubule segment 1 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "metanephric S1 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072031 ! proximal convoluted tubule segment 1 development +relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development + +[Term] +id: GO:0072232 +name: metanephric proximal convoluted tubule segment 2 development +namespace: biological_process +def: "The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "metanephric S2 development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072032 ! proximal convoluted tubule segment 2 development +relationship: part_of GO:0072229 ! metanephric proximal convoluted tubule development + +[Term] +id: GO:0072233 +name: metanephric thick ascending limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule." [GOC:mtg_kidney_jan10] +synonym: "metanephric TAL development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072023 ! thick ascending limb development +is_a: GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072235 ! metanephric distal tubule development + +[Term] +id: GO:0072234 +name: metanephric nephron tubule development +namespace: biological_process +def: "The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072080 ! nephron tubule development +is_a: GO:0072170 ! metanephric tubule development +is_a: GO:0072243 ! metanephric nephron epithelium development + +[Term] +id: GO:0072235 +name: metanephric distal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072017 ! distal tubule development +is_a: GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:0072236 +name: metanephric loop of Henle development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric intermediate tubule development" EXACT [] +is_a: GO:0072070 ! loop of Henle development +is_a: GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:0072237 +name: metanephric proximal tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072014 ! proximal tubule development +is_a: GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:0072238 +name: metanephric long nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric juxtamedullary nephron development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072029 ! long nephron development +is_a: GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072239 +name: metanephric glomerulus vasculature development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] +synonym: "glomerulus capillary development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072012 ! glomerulus vasculature development +relationship: part_of GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072240 +name: metanephric DCT cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "metanephric distal convoluted tubule cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072069 ! DCT cell differentiation +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072221 ! metanephric distal convoluted tubule development + +[Term] +id: GO:0072241 +name: metanephric DCT cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +synonym: "metanephric distal convoluted tubule cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072140 ! DCT cell development +relationship: part_of GO:0072240 ! metanephric DCT cell differentiation + +[Term] +id: GO:0072242 +name: metanephric DCT cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell." [GOC:mtg_kidney_jan10] +synonym: "metanephric distal convoluted tubule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072146 ! DCT cell fate commitment +relationship: part_of GO:0072240 ! metanephric DCT cell differentiation + +[Term] +id: GO:0072243 +name: metanephric nephron epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072009 ! nephron epithelium development +is_a: GO:0072207 ! metanephric epithelium development + +[Term] +id: GO:0072244 +name: metanephric glomerular epithelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072010 ! glomerular epithelium development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072245 +name: metanephric glomerular parietal epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +is_a: GO:0072139 ! glomerular parietal epithelial cell differentiation +is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation + +[Term] +id: GO:0072246 +name: metanephric glomerular parietal epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport." [GOC:mtg_kidney_jan10] +synonym: "metanephric Bowman's capsule development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072016 ! glomerular parietal epithelial cell development +is_a: GO:0072313 ! metanephric glomerular epithelial cell development +relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0072247 +name: metanephric glomerular parietal epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes." [GOC:mtg_kidney_jan10] +synonym: "metanephric Bowman's capsule cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072147 ! glomerular parietal epithelial cell fate commitment +is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment +relationship: part_of GO:0072245 ! metanephric glomerular parietal epithelial cell differentiation + +[Term] +id: GO:0072248 +name: metanephric glomerular visceral epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric podocyte differentiation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072112 ! glomerular visceral epithelial cell differentiation +is_a: GO:0072312 ! metanephric glomerular epithelial cell differentiation + +[Term] +id: GO:0072249 +name: metanephric glomerular visceral epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric podocyte development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072015 ! glomerular visceral epithelial cell development +is_a: GO:0072313 ! metanephric glomerular epithelial cell development +relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0072250 +name: metanephric glomerular visceral epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric podocyte cell fate commitment" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072149 ! glomerular visceral epithelial cell fate commitment +is_a: GO:0072315 ! metanephric glomerular epithelial cell fate commitment +relationship: part_of GO:0072248 ! metanephric glomerular visceral epithelial cell differentiation + +[Term] +id: GO:0072251 +name: metanephric juxtaglomerulus cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0072052 ! juxtaglomerulus cell differentiation +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072206 ! metanephric juxtaglomerular apparatus development + +[Term] +id: GO:0072252 +name: metanephric juxtaglomerulus cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072142 ! juxtaglomerulus cell development +relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation + +[Term] +id: GO:0072253 +name: metanephric juxtaglomerulus cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell." [GOC:mtg_kidney_jan10] +is_a: GO:0072150 ! juxtaglomerulus cell fate commitment +relationship: part_of GO:0072251 ! metanephric juxtaglomerulus cell differentiation + +[Term] +id: GO:0072254 +name: metanephric glomerular mesangial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0072008 ! glomerular mesangial cell differentiation +is_a: GO:0072209 ! metanephric mesangial cell differentiation +relationship: part_of GO:0072223 ! metanephric glomerular mesangium development + +[Term] +id: GO:0072255 +name: metanephric glomerular mesangial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +is_a: GO:0072144 ! glomerular mesangial cell development +relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation + +[Term] +id: GO:0072256 +name: metanephric glomerular mesangial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell." [GOC:mtg_kidney_jan10] +is_a: GO:0072152 ! glomerular mesangial cell fate commitment +relationship: part_of GO:0072254 ! metanephric glomerular mesangial cell differentiation + +[Term] +id: GO:0072257 +name: metanephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +is_a: GO:0072160 ! nephron tubule epithelial cell differentiation +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:0072258 +name: metanephric interstitial fibroblast differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10] +synonym: "metanephros interstitial cell differentiation" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072071 ! kidney interstitial fibroblast differentiation +is_a: GO:0072202 ! cell differentiation involved in metanephros development + +[Term] +id: GO:0072259 +name: metanephric interstitial fibroblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure." [GOC:mtg_kidney_jan10] +synonym: "metanephros interstitial cell development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072141 ! renal interstitial fibroblast development +relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation + +[Term] +id: GO:0072260 +name: metanephric interstitial fibroblast fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast." [GOC:mtg_kidney_jan10] +synonym: "metanephros interstitial cell fate commitment" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072153 ! renal interstitial fibroblast fate commitment +relationship: part_of GO:0072258 ! metanephric interstitial fibroblast differentiation + +[Term] +id: GO:0072261 +name: metanephric extraglomerular mesangial cell proliferation involved in metanephros development +namespace: biological_process +def: "The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." [GOC:mtg_kidney_jan10] +synonym: "metanephric Goormaghtigh proliferation" RELATED [GOC:mtg_kidney_jan10] +synonym: "metanephric lacis cell proliferation" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0072122 ! extraglomerular mesangial cell proliferation +is_a: GO:0072203 ! cell proliferation involved in metanephros development +relationship: part_of GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072262 +name: metanephric glomerular mesangial cell proliferation involved in metanephros development +namespace: biological_process +def: "The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population." [GOC:mtg_kidney_jan10] +is_a: GO:0072110 ! glomerular mesangial cell proliferation +is_a: GO:0072203 ! cell proliferation involved in metanephros development +relationship: part_of GO:0072223 ! metanephric glomerular mesangium development + +[Term] +id: GO:0072263 +name: metanephric intraglomerular mesangial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis." [GOC:mtg_kidney_jan10] +is_a: GO:0072123 ! intraglomerular mesangial cell proliferation +is_a: GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development + +[Term] +id: GO:0072264 +name: metanephric glomerular endothelium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072011 ! glomerular endothelium development +is_a: GO:0072244 ! metanephric glomerular epithelium development +relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development + +[Term] +id: GO:0072265 +name: metanephric capsule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] +is_a: GO:0072128 ! renal capsule morphogenesis +relationship: part_of GO:0072213 ! metanephric capsule development + +[Term] +id: GO:0072266 +name: metanephric capsule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." [GOC:mtg_kidney_jan10] +is_a: GO:0072129 ! renal capsule formation +relationship: part_of GO:0072265 ! metanephric capsule morphogenesis + +[Term] +id: GO:0072267 +name: metanephric capsule specification +namespace: biological_process +def: "The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:mtg_kidney_jan10] +is_a: GO:0072130 ! renal capsule specification +is_a: GO:0072268 ! pattern specification involved in metanephros development +relationship: part_of GO:0072266 ! metanephric capsule formation + +[Term] +id: GO:0072268 +name: pattern specification involved in metanephros development +namespace: biological_process +def: "Any developmental process that results in the creation of defined areas or spaces within the metanephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10] +synonym: "metanephros pattern formation" RELATED [GOC:mtg_kidney_jan10] +synonym: "metanephros pattern specification" EXACT [GOC:mtg_kidney_jan10] +synonym: "pattern formation involved in metanephros development" RELATED [GOC:mtg_kidney_jan10] +is_a: GO:0061004 ! pattern specification involved in kidney development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:0072269 +name: metanephric long descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." [GOC:mtg_kidney_jan10] +is_a: GO:0072064 ! long descending thin limb development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072238 ! metanephric long nephron development + +[Term] +id: GO:0072270 +name: metanephric short nephron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb." [GOC:mtg_kidney_jan10] +is_a: GO:0072030 ! short nephron development +is_a: GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072271 +name: metanephric short descending thin limb development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072063 ! short descending thin limb development +is_a: GO:0072243 ! metanephric nephron epithelium development +relationship: part_of GO:0072270 ! metanephric short nephron development + +[Term] +id: GO:0072272 +name: proximal/distal pattern formation involved in metanephric nephron development +namespace: biological_process +def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end)." [GOC:mtg_kidney_jan10] +synonym: "proximal-distal pattern formation involved in metanephric nephron development" EXACT [GOC:mtg_kidney_jan10] +synonym: "proximal/distal metanephric nephron patterning" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072047 ! proximal/distal pattern formation involved in nephron development +is_a: GO:0072268 ! pattern specification involved in metanephros development +relationship: part_of GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072273 +name: metanephric nephron morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072028 ! nephron morphogenesis +relationship: part_of GO:0003338 ! metanephros morphogenesis +relationship: part_of GO:0072210 ! metanephric nephron development + +[Term] +id: GO:0072274 +name: metanephric glomerular basement membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration." [GOC:mtg_kidney_jan10] +is_a: GO:0032836 ! glomerular basement membrane development +relationship: part_of GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072275 +name: metanephric glomerulus morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072102 ! glomerulus morphogenesis +relationship: part_of GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072276 +name: metanephric glomerulus vasculature morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus." [GOC:mtg_kidney_jan10] +is_a: GO:0072103 ! glomerulus vasculature morphogenesis +relationship: part_of GO:0072239 ! metanephric glomerulus vasculature development +relationship: part_of GO:0072275 ! metanephric glomerulus morphogenesis + +[Term] +id: GO:0072277 +name: metanephric glomerular capillary formation +namespace: biological_process +def: "The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts." [GOC:mtg_kidney_jan10] +is_a: GO:0072104 ! glomerular capillary formation +relationship: part_of GO:0072276 ! metanephric glomerulus vasculature morphogenesis + +[Term] +id: GO:0072278 +name: metanephric comma-shaped body morphogenesis +namespace: biological_process +def: "The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072049 ! comma-shaped body morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072279 +name: convergent extension involved in metanephric nephron morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the renal epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072045 ! convergent extension involved in nephron morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072280 +name: establishment of planar polarity involved in metanephric nephron morphogenesis +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the shaping of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "establishment of planar cell polarity involved in metanephric nephron morphogenesis" NARROW [GOC:mtg_kidney_jan10] +is_a: GO:0072046 ! establishment of planar polarity involved in nephron morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072281 +name: mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0061208 ! cell differentiation involved in mesonephros development +is_a: GO:0072037 ! mesenchymal stem cell differentiation involved in nephron morphogenesis +is_a: GO:0072202 ! cell differentiation involved in metanephros development +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072282 +name: metanephric nephron tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072078 ! nephron tubule morphogenesis +is_a: GO:0072173 ! metanephric tubule morphogenesis +relationship: part_of GO:0072234 ! metanephric nephron tubule development +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072283 +name: metanephric renal vesicle morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072077 ! renal vesicle morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072284 +name: metanephric S-shaped body morphogenesis +namespace: biological_process +def: "The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072050 ! S-shaped body morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072285 +name: mesenchymal to epithelial transition involved in metanephric renal vesicle formation +namespace: biological_process +def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle." [GOC:mtg_kidney_jan10] +is_a: GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis +is_a: GO:0072036 ! mesenchymal to epithelial transition involved in renal vesicle formation +relationship: part_of GO:0072093 ! metanephric renal vesicle formation + +[Term] +id: GO:0072286 +name: metanephric connecting tubule development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros." [GOC:mtg_kidney_jan10] +synonym: "metanephric connecting duct development" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072027 ! connecting tubule development +is_a: GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:0072287 +name: metanephric distal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule." [GOC:mtg_kidney_jan10] +is_a: GO:0072156 ! distal tubule morphogenesis +is_a: GO:0072282 ! metanephric nephron tubule morphogenesis +relationship: part_of GO:0072235 ! metanephric distal tubule development + +[Term] +id: GO:0072288 +name: metanephric proximal tubule morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology." [GOC:mtg_kidney_jan10] +is_a: GO:0072158 ! proximal tubule morphogenesis +is_a: GO:0072282 ! metanephric nephron tubule morphogenesis +relationship: part_of GO:0072237 ! metanephric proximal tubule development + +[Term] +id: GO:0072289 +name: metanephric nephron tubule formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072079 ! nephron tubule formation +is_a: GO:0072174 ! metanephric tubule formation +relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis + +[Term] +id: GO:0072290 +name: epithelial cell migration involved in metanephric nephron tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric nephron tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0035788 ! cell migration involved in metanephros development +is_a: GO:0072155 ! epithelial cell migration involved in nephron tubule morphogenesis +relationship: part_of GO:0072282 ! metanephric nephron tubule morphogenesis + +[Term] +id: GO:0072291 +name: epithelial cell migration involved in metanephric distal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric distal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0072157 ! epithelial cell migration involved in distal tubule morphogenesis +is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis +relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis + +[Term] +id: GO:0072292 +name: epithelial cell migration involved in metanephric proximal tubule morphogenesis +namespace: biological_process +def: "The orderly movement of epithelial cells within a renal tubule that contributes to metanephric proximal tubule morphogenesis." [GOC:mtg_kidney_jan10] +is_a: GO:0072159 ! epithelial cell migration involved in proximal tubule morphogenesis +is_a: GO:0072290 ! epithelial cell migration involved in metanephric nephron tubule morphogenesis +relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis + +[Term] +id: GO:0072293 +name: specification of metanephric nephron tubule identity +namespace: biological_process +def: "The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072081 ! specification of nephron tubule identity +is_a: GO:0072268 ! pattern specification involved in metanephros development +relationship: part_of GO:0072272 ! proximal/distal pattern formation involved in metanephric nephron development +relationship: part_of GO:0072289 ! metanephric nephron tubule formation + +[Term] +id: GO:0072294 +name: specification of metanephric connecting tubule identity +namespace: biological_process +def: "The process in which the connecting tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072085 ! specification of connecting tubule identity +is_a: GO:0072293 ! specification of metanephric nephron tubule identity +relationship: part_of GO:0072286 ! metanephric connecting tubule development + +[Term] +id: GO:0072295 +name: specification of metanephric distal tubule identity +namespace: biological_process +def: "The process in which the distal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072084 ! specification of distal tubule identity +is_a: GO:0072293 ! specification of metanephric nephron tubule identity +relationship: part_of GO:0072287 ! metanephric distal tubule morphogenesis + +[Term] +id: GO:0072296 +name: specification of metanephric loop of Henle identity +namespace: biological_process +def: "The process in which the loop of Henle of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +synonym: "specification of metanephric intermediate tubule identity" EXACT [GOC:mtg_kidney_jan10] +is_a: GO:0072086 ! specification of loop of Henle identity +is_a: GO:0072293 ! specification of metanephric nephron tubule identity +relationship: part_of GO:0072236 ! metanephric loop of Henle development + +[Term] +id: GO:0072297 +name: specification of metanephric proximal tubule identity +namespace: biological_process +def: "The process in which the proximal tubule of the metanephric nephron acquires its identity." [GOC:bf, GOC:mtg_kidney_jan10] +is_a: GO:0072082 ! specification of proximal tubule identity +is_a: GO:0072293 ! specification of metanephric nephron tubule identity +relationship: part_of GO:0072288 ! metanephric proximal tubule morphogenesis + +[Term] +id: GO:0072298 +name: regulation of metanephric glomerulus development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0001656 ! metanephros development +is_a: GO:0090192 ! regulation of glomerulus development +relationship: regulates GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072299 +name: negative regulation of metanephric glomerulus development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072217 ! negative regulation of metanephros development +is_a: GO:0072298 ! regulation of metanephric glomerulus development +is_a: GO:0090194 ! negative regulation of glomerulus development +relationship: negatively_regulates GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072300 +name: positive regulation of metanephric glomerulus development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." [GOC:mtg_kidney_jan10] +is_a: GO:0072216 ! positive regulation of metanephros development +is_a: GO:0072298 ! regulation of metanephric glomerulus development +is_a: GO:0090193 ! positive regulation of glomerulus development +relationship: positively_regulates GO:0072224 ! metanephric glomerulus development + +[Term] +id: GO:0072301 +name: regulation of metanephric glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation +relationship: regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development + +[Term] +id: GO:0072302 +name: negative regulation of metanephric glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation +is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation +relationship: negatively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development + +[Term] +id: GO:0072303 +name: positive regulation of glomerular metanephric mesangial cell proliferation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation +is_a: GO:0072301 ! regulation of metanephric glomerular mesangial cell proliferation +relationship: positively_regulates GO:0072262 ! metanephric glomerular mesangial cell proliferation involved in metanephros development + +[Term] +id: GO:0072304 +name: regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +namespace: biological_process +def: "Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] +synonym: "regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] +is_a: GO:0072039 ! regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development +relationship: regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis +relationship: regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis + +[Term] +id: GO:0072305 +name: negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +namespace: biological_process +def: "Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] +synonym: "negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] +is_a: GO:0072040 ! negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +is_a: GO:1900212 ! negative regulation of mesenchymal cell apoptotic process involved in metanephros development +relationship: negatively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis +relationship: negatively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis + +[Term] +id: GO:0072306 +name: positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +namespace: biological_process +def: "Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10] +synonym: "positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis" NARROW [] +synonym: "positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis" EXACT [] +is_a: GO:0072041 ! positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis +is_a: GO:0072304 ! regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +is_a: GO:1900213 ! positive regulation of mesenchymal cell apoptotic process involved in metanephros development +relationship: positively_regulates GO:0072309 ! mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis +relationship: positively_regulates GO:1901147 ! mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis + +[Term] +id: GO:0072307 +name: regulation of metanephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation +relationship: regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation + +[Term] +id: GO:0072308 +name: negative regulation of metanephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation +is_a: GO:0072307 ! regulation of metanephric nephron tubule epithelial cell differentiation +relationship: negatively_regulates GO:0072257 ! metanephric nephron tubule epithelial cell differentiation + +[Term] +id: GO:0072309 +name: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis +namespace: biological_process +def: "The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072038 ! mesenchymal stem cell maintenance involved in nephron morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:0072310 +name: glomerular epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation + +[Term] +id: GO:0072311 +name: glomerular epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development +relationship: part_of GO:0072010 ! glomerular epithelium development + +[Term] +id: GO:0072312 +name: metanephric glomerular epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072202 ! cell differentiation involved in metanephros development +is_a: GO:0072311 ! glomerular epithelial cell differentiation +relationship: part_of GO:0072244 ! metanephric glomerular epithelium development + +[Term] +id: GO:0072313 +name: metanephric glomerular epithelial cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072310 ! glomerular epithelial cell development +relationship: part_of GO:0072312 ! metanephric glomerular epithelial cell differentiation + +[Term] +id: GO:0072314 +name: glomerular epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0002064 ! epithelial cell development +relationship: part_of GO:0072311 ! glomerular epithelial cell differentiation + +[Term] +id: GO:0072315 +name: metanephric glomerular epithelial cell fate commitment +namespace: biological_process +def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells." [GOC:mtg_kidney_jan10] +is_a: GO:0072314 ! glomerular epithelial cell fate commitment + +[Term] +id: GO:0072316 +name: alpha-glucan catabolic process involved in ascospore release from ascus +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus." [GOC:mah] +synonym: "alpha-glucan breakdown involved in ascospore release from ascus" EXACT [GOC:mah] +synonym: "alpha-glucan catabolism involved in ascospore release from ascus" EXACT [GOC:mah] +synonym: "alpha-glucan degradation involved in ascospore release from ascus" EXACT [GOC:mah] +is_a: GO:0030980 ! alpha-glucan catabolic process +is_a: GO:0072000 ! extracellular polysaccharide catabolic process involved in ascospore release from ascus + +[Term] +id: GO:0072317 +name: obsolete glucan endo-1,3-beta-D-glucosidase activity involved in ascospore release from ascus +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans that contributes to the release of ascospores from the ascus." [GOC:jl] +comment: This term was obsoleted because it should be captured as a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0072318 +name: clathrin coat disassembly +namespace: biological_process +def: "The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system." [PMID:11084334, PMID:11146663, PMID:8524399] +synonym: "clathrin-coat disassembly" EXACT [GOC:rb] +synonym: "clathrin-coat uncoating" EXACT [GOC:rb] +synonym: "clathrin-coated vesicle uncoating" EXACT [GOC:mah] +is_a: GO:0072319 ! vesicle uncoating + +[Term] +id: GO:0072319 +name: vesicle uncoating +namespace: biological_process +def: "A protein depolymerization process that results in the disassembly of vesicle coat proteins." [GOC:mah] +synonym: "vesicle coat disassembly" EXACT [GOC:mah] +is_a: GO:0051261 ! protein depolymerization +relationship: part_of GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0072320 +name: volume-sensitive chloride channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:mah] +synonym: "swell-activated chloride channel" RELATED [GOC:sart, PMID:23056495] +is_a: GO:0005225 ! volume-sensitive anion channel activity +is_a: GO:0005254 ! chloride channel activity + +[Term] +id: GO:0072321 +name: obsolete chaperone-mediated protein transport +namespace: biological_process +def: "OBSOLETE. The directed movement of proteins into, out of or within a cell, or between cells, mediated by chaperone molecules that bind to the transported proteins." [GOC:mah, PMID:20378773] +comment: This term was obsoleted because it represents a function within a process. +is_obsolete: true +consider: GO:0015031 +consider: GO:0140597 + +[Term] +id: GO:0072322 +name: protein transport across periplasmic space +namespace: biological_process +alt_id: GO:0072323 +def: "The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall." [GOC:mah, PMID:20378773] +synonym: "chaperone-mediated protein transport across periplasmic space" NARROW [] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0072324 +name: ascus epiplasm +namespace: cellular_component +def: "Ascus cytoplasm that is not packaged into ascospores." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mcc] +comment: Note that this term is an is_a child of 'cell part' because the epiplasm is extracellular to the spore (each of which is a cell) but within the ascus structure, and originated from cytoplasm. +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0072325 +name: vulval cell fate commitment +namespace: biological_process +def: "The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0040025 ! vulval development + +[Term] +id: GO:0072326 +name: vulval cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] +is_a: GO:0001709 ! cell fate determination +relationship: part_of GO:0072325 ! vulval cell fate commitment + +[Term] +id: GO:0072327 +name: vulval cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes." [GOC:kmv, GOC:mah, ISBN:087969307X, PMID:11236714] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0072325 ! vulval cell fate commitment + +[Term] +id: GO:0072328 +name: alkene binding +namespace: molecular_function +def: "Binding to an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [GOC:mah] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0072329 +name: monocarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process + +[Term] +id: GO:0072330 +name: monocarboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [GOC:mah] +synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] +synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] +synonym: "monocarboxylic acid formation" EXACT [GOC:mah] +synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process + +[Term] +id: GO:0072331 +name: signal transduction by p53 class mediator +namespace: biological_process +def: "An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein." [GOC:mah] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0072332 +name: intrinsic apoptotic signaling pathway by p53 class mediator +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] +synonym: "intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [] +synonym: "signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [] +is_a: GO:0072331 ! signal transduction by p53 class mediator +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:0072333 +name: obsolete anoikis by p53 class mediator +namespace: biological_process +def: "OBSOLETE. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, that results in the induction of anoikis." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +comment: This term was made obsolete because it is misleading, since anoikis occurs following detachment of cells from each other and/or from the culture surface; it is not p53 that induces such separation. +synonym: "anoikis by p53 class mediator" EXACT [] +synonym: "anoikis by signal transduction by p53 class mediator" EXACT [] +synonym: "signal transduction by p53 class mediator resulting in induction of anoikis" RELATED [] +is_obsolete: true + +[Term] +id: GO:0072334 +name: UDP-galactose transmembrane transport +namespace: biological_process +alt_id: GO:0015785 +def: "The process in which UDP-galactose is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "UDP-galactose membrane transport" EXACT [] +synonym: "UDP-galactose transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0072335 +name: regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] +synonym: "regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation + +[Term] +id: GO:0072336 +name: negative regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dgh] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" RELATED [] +synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] +is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +relationship: negatively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation + +[Term] +id: GO:0072337 +name: modified amino acid transport +namespace: biological_process +def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "amino acid derivative transport" EXACT [] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0072338 +name: cellular lactam metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah] +synonym: "cellular lactam metabolism" EXACT [GOC:mah] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0044281 ! small molecule metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:0072339 +name: cellular lactam biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah] +synonym: "cellular lactam anabolism" EXACT [GOC:mah] +synonym: "cellular lactam biosynthesis" EXACT [GOC:mah] +synonym: "cellular lactam formation" EXACT [GOC:mah] +synonym: "cellular lactam synthesis" EXACT [GOC:mah] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0072338 ! cellular lactam metabolic process + +[Term] +id: GO:0072340 +name: cellular lactam catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [GOC:mah] +synonym: "cellular lactam breakdown" EXACT [GOC:mah] +synonym: "cellular lactam catabolism" EXACT [GOC:mah] +synonym: "cellular lactam degradation" EXACT [GOC:mah] +is_a: GO:0043605 ! cellular amide catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072338 ! cellular lactam metabolic process + +[Term] +id: GO:0072341 +name: modified amino acid binding +namespace: molecular_function +def: "Binding to a modified amino acid." [GOC:mah] +synonym: "amino acid derivative binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0072342 +name: response to anion stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment." [GOC:cvs, PMID:19641131] +is_a: GO:0009651 ! response to salt stress + +[Term] +id: GO:0072343 +name: pancreatic stellate cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of pancreatic stellate cells, resulting in the expansion of a pancreatic stellate cell population. Pancreatic stellate cells are found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and have long cytoplasmic processes that encircle the base of the acinus." [CL:0002410, GOC:mah, PMID:17200706] +is_a: GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:0072344 +name: rescue of stalled ribosome +namespace: biological_process +def: "A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex." [GOC:jh2, GOC:mah, PMID:18557701, PMID:19170872, PMID:20117091, PMID:20185543] +is_a: GO:0006414 ! translational elongation + +[Term] +id: GO:0072345 +name: NAADP-sensitive calcium-release channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts." [PMID:19387438, PMID:19557428] +xref: Reactome:R-HSA-2685505 "TPCN1/2 transport lysosomal Ca2+ to cytosol" +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0072346 +name: cADPR-sensitive calcium-release channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts." [PMID:11752598] +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0072347 +name: response to anesthetic +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation." [GOC:sart] +synonym: "response to anaesthetic" EXACT [GOC:mah] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0072348 +name: sulfur compound transport +namespace: biological_process +def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] +synonym: "sulfur-containing compound transport" EXACT [GOC:mah] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0072349 +name: modified amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of modified amino acids from one side of a membrane to the other." [GOC:mah] +synonym: "amino acid derivative transmembrane transporter activity" EXACT [] +synonym: "modified amino acid transporter activity" BROAD [GOC:mah] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0072350 +name: tricarboxylic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-)." [GOC:mah] +synonym: "tricarboxylic acid metabolism" EXACT [GOC:mah] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0072351 +name: tricarboxylic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [GOC:mah] +synonym: "tricarboxylate biosynthesis" EXACT [GOC:mah] +synonym: "tricarboxylate biosynthetic process" EXACT [GOC:mah] +synonym: "tricarboxylic acid anabolism" EXACT [GOC:mah] +synonym: "tricarboxylic acid biosynthesis" EXACT [GOC:mah] +synonym: "tricarboxylic acid formation" EXACT [GOC:mah] +synonym: "tricarboxylic acid synthesis" EXACT [GOC:mah] +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process + +[Term] +id: GO:0072352 +name: tricarboxylic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups." [GOC:mah] +synonym: "tricarboxylate catabolic process" EXACT [GOC:mah] +synonym: "tricarboxylate catabolism" EXACT [GOC:mah] +synonym: "tricarboxylic acid breakdown" EXACT [GOC:mah] +synonym: "tricarboxylic acid catabolism" EXACT [GOC:mah] +synonym: "tricarboxylic acid degradation" EXACT [GOC:mah] +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:0072350 ! tricarboxylic acid metabolic process + +[Term] +id: GO:0072353 +name: cellular age-dependent response to reactive oxygen species +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:mah] +is_a: GO:0001315 ! age-dependent response to reactive oxygen species +is_a: GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:0072354 +name: histone kinase activity (H3-T3 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3." [GOC:mah] +synonym: "histone threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] +synonym: "histone-threonine kinase activity (H3-T3 specific)" EXACT [GOC:mah] +is_a: GO:0035184 ! histone threonine kinase activity + +[Term] +id: GO:0072355 +name: histone H3-T3 phosphorylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone." [GOC:mah] +is_a: GO:0035405 ! histone-threonine phosphorylation + +[Term] +id: GO:0072356 +name: chromosome passenger complex localization to kinetochore +namespace: biological_process +def: "A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis." [GOC:mah] +synonym: "chromosomal passenger complex localization to kinetochore" EXACT [GOC:mah] +synonym: "chromosome passenger complex localisation to kinetochore" RELATED [GOC:mah] +synonym: "CPC complex localization to kinetochore" EXACT [GOC:vw] +synonym: "CPC localization to kinetochore" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0034501 ! protein localization to kinetochore + +[Term] +id: GO:0072357 +name: PTW/PP1 phosphatase complex +namespace: cellular_component +def: "A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase." [GOC:mah, PMID:20516061] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex + +[Term] +id: GO:0072359 +name: circulatory system development +namespace: biological_process +alt_id: GO:0072358 +def: "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis." [GOC:mah, UBERON:0001009] +subset: goslim_drosophila +synonym: "cardiovascular system development" NARROW [] +is_a: GO:0048731 ! system development + +[Term] +id: GO:0072360 +name: vascular cord development +namespace: biological_process +def: "The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis." [GOC:mah, PMID:7084422, ZFA:0005077] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0072359 ! circulatory system development + +[Term] +id: GO:0072361 +name: obsolete regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0072362 +name: obsolete regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: The reason for obsoletion is that this term represented a GO-CAM model. +synonym: "regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0072363 +name: obsolete regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glycolysis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0072364 +name: obsolete regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of cellular ketone metabolic process by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +synonym: "regulation of cellular ketone metabolism by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072365 +name: obsolete regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +synonym: "regulation of cellular ketone metabolism by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072366 +name: obsolete regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cellular ketone metabolic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +synonym: "regulation of cellular ketone metabolism by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072367 +name: obsolete regulation of lipid transport by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of lipid transport by regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0072368 +name: obsolete regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0072369 +name: obsolete regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:mah] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter" EXACT [GOC:bf] +is_obsolete: true + +[Term] +id: GO:0072370 +name: histone H2A-S121 phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone." [GOC:mah, PMID:19965387] +synonym: "histone H2A phosphorylation at S121" EXACT [GOC:mah] +synonym: "histone H2AS121 phosphorylation" EXACT [GOC:mah] +is_a: GO:0035404 ! histone-serine phosphorylation +is_a: GO:1990164 ! histone H2A phosphorylation + +[Term] +id: GO:0072371 +name: histone kinase activity (H2A-S121 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A." [GOC:mah, PMID:19965387] +synonym: "histone serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] +synonym: "histone-serine kinase activity (H2A-S121 specific)" EXACT [GOC:mah] +is_a: GO:0035174 ! histone serine kinase activity + +[Term] +id: GO:0072373 +name: alpha-carotene epsilon hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] +is_a: GO:0072374 ! carotene epsilon hydroxylase activity + +[Term] +id: GO:0072374 +name: carotene epsilon hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [GOC:mah, MetaCyc:CPD-7421, MetaCyc:CPD1F-118, MetaCyc:RXN-5962] +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0072375 +name: medium-term memory +namespace: biological_process +def: "The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster)." [GOC:sart, PMID:14659098, PMID:7923375] +synonym: "middle-term memory" EXACT [GOC:sart] +synonym: "MTM" NARROW [GOC:sart] +is_a: GO:0007613 ! memory + +[Term] +id: GO:0072376 +name: protein activation cascade +namespace: biological_process +def: "A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events." [GOC:add, GOC:mah, GOC:pde] +synonym: "protein activation pathway" EXACT [GOC:add] +synonym: "protein activitory cascade" EXACT [GOC:add] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0050896 ! response to stimulus + +[Term] +id: GO:0072377 +name: blood coagulation, common pathway +namespace: biological_process +def: "A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex." [GOC:add, GOC:mah, GOC:pde, PMID:1931959] +comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. +is_a: GO:0072376 ! protein activation cascade +relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation + +[Term] +id: GO:0072378 +name: blood coagulation, fibrin clot formation +namespace: biological_process +def: "A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events." [GOC:add, GOC:mah, GOC:pde] +comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. +is_a: GO:0072376 ! protein activation cascade +relationship: part_of GO:0007596 ! blood coagulation + +[Term] +id: GO:0072379 +name: ER membrane insertion complex +namespace: cellular_component +def: "A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast." [GOC:mah, PMID:20676083, PMID:20850366] +synonym: "endoplasmic reticulum membrane insertion complex" EXACT [GOC:mah] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0072380 +name: TRC complex +namespace: cellular_component +def: "A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane." [GOC:mah, PMID:20850366, PMID:23142665] +synonym: "GET4-GET5 transmembrane domain recognition complex" RELATED [] +synonym: "TMD recognition complex" EXACT [PMID:20850366] +is_a: GO:0072379 ! ER membrane insertion complex + +[Term] +id: GO:0072381 +name: positive regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin involved in neural crest cell differentiation. The Wnt signaling pathway is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mah] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in neural crest cell differentiation" EXACT [] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in neural crest cell differentiation" EXACT [GOC:mah] +synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in neural crest cell differentiation" EXACT [GOC:signaling] +synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin involved in neural crest cell differentiation" EXACT [GOC:mah] +is_a: GO:0072335 ! regulation of canonical Wnt signaling pathway involved in neural crest cell differentiation +is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway +relationship: positively_regulates GO:0044335 ! canonical Wnt signaling pathway involved in neural crest cell differentiation + +[Term] +id: GO:0072382 +name: minus-end-directed vesicle transport along microtubule +namespace: biological_process +def: "The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] +synonym: "microtubule minus-end-directed vesicle distribution" NARROW [GOC:rl] +synonym: "microtubule minus-end-directed vesicle localization" EXACT [GOC:rl] +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0072385 ! minus-end-directed organelle transport along microtubule + +[Term] +id: GO:0072383 +name: plus-end-directed vesicle transport along microtubule +namespace: biological_process +def: "The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination." [GOC:BHF, GOC:mah] +synonym: "microtubule plus-end-directed vesicle distribution" NARROW [GOC:rl] +synonym: "microtubule plus-end-directed vesicle localization" EXACT [GOC:rl] +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0072386 ! plus-end-directed organelle transport along microtubule + +[Term] +id: GO:0072384 +name: organelle transport along microtubule +namespace: biological_process +def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] +synonym: "microtubule-based organelle localization" EXACT [GOC:rl] +is_a: GO:0010970 ! transport along microtubule +is_a: GO:0051656 ! establishment of organelle localization + +[Term] +id: GO:0072385 +name: minus-end-directed organelle transport along microtubule +namespace: biological_process +def: "The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] +synonym: "microtubule minus-end-directed organelle distribution" NARROW [GOC:rl] +synonym: "microtubule minus-end-directed organelle localization" EXACT [GOC:rl] +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0072386 +name: plus-end-directed organelle transport along microtubule +namespace: biological_process +def: "The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:BHF, GOC:mah] +synonym: "microtubule plus-end-directed organelle distribution" NARROW [GOC:rl] +synonym: "microtubule plus-end-directed organelle localization" EXACT [GOC:rl] +is_a: GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:0072387 +name: flavin adenine dinucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +synonym: "FAD or FADH2 metabolic process" EXACT [] +synonym: "flavin adenine dinucleotide metabolism" EXACT [] +synonym: "flavin-adenine dinucleotide metabolic process" EXACT [] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0042726 ! flavin-containing compound metabolic process + +[Term] +id: GO:0072388 +name: flavin adenine dinucleotide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +synonym: "FAD or FADH2 biosynthetic process" EXACT [] +synonym: "flavin adenine dinucleotide anabolism" EXACT [] +synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] +synonym: "flavin adenine dinucleotide formation" EXACT [] +synonym: "flavin adenine dinucleotide synthesis" EXACT [] +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:0042727 ! flavin-containing compound biosynthetic process +is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process + +[Term] +id: GO:0072389 +name: flavin adenine dinucleotide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of flavin adenine dinucleotide, which acts as a coenzyme or prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:mah] +synonym: "FAD or FADH2 catabolic process" EXACT [] +synonym: "flavin adenine dinucleotide breakdown" EXACT [] +synonym: "flavin adenine dinucleotide catabolism" EXACT [] +synonym: "flavin adenine dinucleotide degradation" EXACT [] +is_a: GO:0009166 ! nucleotide catabolic process +is_a: GO:0042728 ! flavin-containing compound catabolic process +is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process + +[Term] +id: GO:0072390 +name: phenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:0072391 +name: phenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072390 ! phenol metabolic process + +[Term] +id: GO:0072392 +name: phenol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phenol, a compound that consists of a benzene ring with one attached hydroxyl group." [GOC:mah] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072390 ! phenol metabolic process + +[Term] +id: GO:0072393 +name: microtubule anchoring at microtubule organizing center +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] +synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah] +synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF] +is_a: GO:0034453 ! microtubule anchoring + +[Term] +id: GO:0072394 +name: obsolete detection of stimulus involved in cell cycle checkpoint +namespace: biological_process +alt_id: GO:0072403 +alt_id: GO:0072406 +def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "cell cycle checkpoint sensor process" RELATED [GOC:mah] +synonym: "detection of stimulus involved in G1/S transition checkpoint" RELATED [] +synonym: "detection of stimulus involved in G2/M transition checkpoint" RELATED [] +synonym: "G1/S transition checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "G1/S transition checkpoint sensor process" RELATED [GOC:mah] +synonym: "G2/M transition checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "G2/M transition checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in cell cycle checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in G1/S transition checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in G2/M transition checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072396 +name: response to cell cycle checkpoint signaling +namespace: biological_process +alt_id: GO:0072405 +alt_id: GO:0072408 +def: "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah] +synonym: "G1/S transition checkpoint effector process" RELATED [GOC:mah] +synonym: "G2/M transition checkpoint effector process" RELATED [GOC:mah] +synonym: "response to G1/S transition checkpoint signaling" RELATED [] +synonym: "response to G2/M transition checkpoint signaling" RELATED [] +synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah] +synonym: "response to signal involved in G1/S transition checkpoint" RELATED [GOC:mah] +synonym: "response to signal involved in G2/M transition checkpoint" RELATED [GOC:mah] +is_a: GO:0071216 ! cellular response to biotic stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus + +[Term] +id: GO:0072397 +name: obsolete detection of stimulus involved in cytokinesis checkpoint +namespace: biological_process +alt_id: GO:0072418 +def: "OBSOLETE. The series of events in which information about the formation and integrity of cytokinetic structures, such as the contractile ring, is received and converted into a molecular signal, contributing to a cytokinesis checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "cytokinesis checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "cytokinesis checkpoint sensor process" RELATED [GOC:mah] +synonym: "detection of stimulus involved in septin checkpoint" RELATED [] +synonym: "sensing involved in cytokinesis checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in septin checkpoint" RELATED [GOC:mah] +synonym: "septin checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "septin checkpoint sensor process" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072398 +name: signal transduction involved in cytokinesis checkpoint +namespace: biological_process +alt_id: GO:0072419 +def: "A signal transduction process that contributes to a cytokinesis checkpoint." [GOC:mtg_cell_cycle] +is_a: GO:0007093 ! mitotic cell cycle checkpoint signaling + +[Term] +id: GO:0072399 +name: response to cytokinesis checkpoint signaling +namespace: biological_process +alt_id: GO:0072420 +def: "A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "cytokinesis checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in cytokinesis checkpoint" EXACT [GOC:mah] +is_a: GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:0072400 +name: obsolete detection of stimulus involved in mitotic DNA integrity checkpoint +namespace: biological_process +alt_id: GO:0072457 +def: "OBSOLETE. The series of events in which information about DNA integrity is received and converted into a molecular signal, contributing to a mitotic DNA integrity checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in mitotic G2/M transition decatenation checkpoint" RELATED [] +synonym: "DNA integrity checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "DNA integrity checkpoint sensor process" RELATED [GOC:mah] +synonym: "mitotic G2/M transition decatenation checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic G2/M transition decatenation checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in DNA integrity checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072402 +name: response to DNA integrity checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah] +is_a: GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:0072409 +name: obsolete detection of stimulus involved in meiotic cell cycle checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a meiotic cell cycle checkpoint." [GOC:mah, GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "meiotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "meiotic cell cycle checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in meiotic cell cycle checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072410 +name: response to meiotic cell cycle checkpoint signaling +namespace: biological_process +def: "A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint." [GOC:mah] +synonym: "meiotic cell cycle checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in meiotic cell cycle checkpoint" EXACT [GOC:mah] +is_a: GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:0072412 +name: obsolete detection of stimulus involved in mitotic cell cycle checkpoint +namespace: biological_process +alt_id: GO:0072454 +alt_id: GO:0072472 +def: "OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in mitotic cell cycle G1/S checkpoint" RELATED [] +synonym: "mitotic cell cycle checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle checkpoint sensor process" RELATED [GOC:mah] +synonym: "mitotic cell cycle G1/S checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle G1/S checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072414 +name: response to mitotic cell cycle checkpoint signaling +namespace: biological_process +alt_id: GO:0072455 +alt_id: GO:0072473 +def: "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah] +synonym: "mitotic cell cycle G1/S checkpoint effector process" RELATED [GOC:mah] +synonym: "mitotic G2/M transition checkpoint effector process" RELATED [GOC:mah] +synonym: "response to mitotic cell cycle G1/S checkpoint signaling" RELATED [] +synonym: "response to mitotic G2/M transition checkpoint signal" RELATED [] +synonym: "response to signal involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] +synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] +synonym: "response to signal involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah] +is_a: GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:0072415 +name: obsolete detection of stimulus involved in spindle checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about the assembly, orientation or integrity of the spindle is received and converted into a molecular signal, contributing to a spindle checkpoint." [GOC:mah, GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "sensing involved in spindle checkpoint" RELATED [GOC:mah] +synonym: "spindle checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "spindle checkpoint sensor process" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072417 +name: response to spindle checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of spindle checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah] +synonym: "spindle checkpoint effector process" EXACT [GOC:mah] +is_a: GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:0072421 +name: obsolete detection of DNA damage stimulus involved in DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a DNA damage checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "DNA damage checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in DNA damage checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072423 +name: response to DNA damage checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah] +is_a: GO:0072402 ! response to DNA integrity checkpoint signaling + +[Term] +id: GO:0072426 +name: response to G2 DNA damage checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah] +is_a: GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:0072427 +name: obsolete detection of DNA damage stimulus involved in intra-S DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to an intra-S DNA damage checkpoint." [GOC:mah] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "intra-S DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "intra-S DNA damage checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in intra-S DNA damage checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072429 +name: response to intra-S DNA damage checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah] +is_a: GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:0072430 +name: obsolete detection of DNA damage stimulus involved in mitotic G1 DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition DNA damage checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of DNA damage stimulus involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] +synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle G1/S transition DNA damage checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072432 +name: response to G1 DNA damage checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:mah] +synonym: "response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [] +synonym: "response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:mah] +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling +is_a: GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:0072433 +name: obsolete detection of DNA damage stimulus involved in mitotic G2 DNA damage checkpoint +namespace: biological_process +alt_id: GO:0072424 +def: "OBSOLETE. The series of events in which information about damage to DNA is received and converted into a molecular signal, contributing to a mitotic G2/M transition DNA damage checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of DNA damage stimulus involved in G2 DNA damage checkpoint" RELATED [] +synonym: "detection of DNA damage stimulus involved in G2/M transition DNA damage checkpoint" RELATED [] +synonym: "detection of DNA damage stimulus involved in mitotic G2/M transition DNA damage checkpoint" EXACT [] +synonym: "G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic G2/M transition DNA damage checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic G2/M transition DNA damage checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in G2/M transition DNA damage checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in mitotic G2/M transition DNA damage checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072435 +name: response to mitotic G2 DNA damage checkpoint signaling +namespace: biological_process +alt_id: GO:0072458 +def: "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic G2/M transition decatenation checkpoint effector process" RELATED [GOC:mah] +synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] +synonym: "response to mitotic G2/M transition decatenation checkpoint signaling" RELATED [] +synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling" EXACT [] +synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] +synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah] +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling +is_a: GO:0072426 ! response to G2 DNA damage checkpoint signaling + +[Term] +id: GO:0072436 +name: obsolete detection of stimulus involved in DNA replication checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a DNA replication checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "DNA replication checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in DNA replication checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072438 +name: response to DNA replication checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "DNA replication checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in DNA replication checkpoint" EXACT [GOC:mah] +is_a: GO:0072402 ! response to DNA integrity checkpoint signaling + +[Term] +id: GO:0072439 +name: obsolete detection of stimulus involved in meiotic DNA replication checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a meiotic DNA replication checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "meiotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "meiotic DNA replication checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in meiotic DNA replication checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072441 +name: response to meiotic DNA replication checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "meiotic DNA replication checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in meiotic DNA replication checkpoint" EXACT [GOC:mah] +is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling +is_a: GO:0072438 ! response to DNA replication checkpoint signaling + +[Term] +id: GO:0072442 +name: obsolete detection of stimulus involved in mitotic DNA replication checkpoint +namespace: biological_process +alt_id: GO:0072445 +def: "OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in S-M checkpoint" RELATED [] +synonym: "mitotic DNA replication checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic DNA replication checkpoint sensor process" RELATED [GOC:mah] +synonym: "S-M checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "S-M checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic DNA replication checkpoint" RELATED [GOC:mah] +synonym: "sensing involved in S-M checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072444 +name: response to mitotic DNA replication checkpoint signaling +namespace: biological_process +alt_id: GO:0072447 +def: "A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic DNA replication checkpoint effector process" EXACT [GOC:mah] +synonym: "response to S-M checkpoint signaling" EXACT [] +synonym: "response to signal involved in mitotic DNA replication checkpoint" EXACT [GOC:mah] +synonym: "response to signal involved in S-M checkpoint" EXACT [GOC:mah] +synonym: "S-M checkpoint effector process" EXACT [GOC:mah] +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling +is_a: GO:0072438 ! response to DNA replication checkpoint signaling + +[Term] +id: GO:0072448 +name: obsolete detection of stimulus involved in G1 cell size control checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a mitotic cell cycle G1/S transition size control checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [] +synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle G1/S transition size control checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle G1/S transition size control checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072449 +name: response to G1 cell size control checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle G1/S transition size control checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in mitotic cell cycle G1/S transition size control checkpoint" EXACT [GOC:mah] +is_a: GO:0072470 ! response to cell size control checkpoint signaling + +[Term] +id: GO:0072451 +name: obsolete detection of stimulus involved in G2 cell size control checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in G2/M transition size control checkpoint" EXACT [] +synonym: "detection of stimulus involved in mitotic cell cycle G2/M transition size control checkpoint" RELATED [GOC:mah] +synonym: "G2/M transition size control checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "G2/M transition size control checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in G2/M transition size control checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072452 +name: response to G2 transition size control checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "G2/M transition size control checkpoint effector process" EXACT [GOC:mah] +synonym: "response to G2/M transition size control checkpoint signaling" EXACT [] +synonym: "response to mitotic cell cycle G2/M transition size control checkpoint signaling" EXACT [GOC:mah] +synonym: "response to signal involved in G2/M transition size control checkpoint" EXACT [GOC:mah] +is_a: GO:0072470 ! response to cell size control checkpoint signaling + +[Term] +id: GO:0072460 +name: obsolete detection of stimulus involved in meiotic recombination checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether recombination is complete is received and converted into a molecular signal, contributing to a meiotic recombination checkpoint." [GOC:mah] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "meiotic recombination checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "meiotic recombination checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in meiotic recombination checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072461 +name: response to meiotic recombination checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "meiotic recombination checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in meiotic recombination checkpoint" EXACT [GOC:mah] +is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0051598 ! meiotic recombination checkpoint signaling + +[Term] +id: GO:0072463 +name: obsolete detection of stimulus involved in meiotic spindle assembly checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether spindle is correctly assembled and chromosomes are attached to the spindle is received and converted into a molecular signal, contributing to a meiotic spindle assembly checkpoint." [GOC:mah] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "meiotic spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "meiotic spindle assembly checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in meiotic spindle assembly checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072464 +name: response to meiotic spindle assembly checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "meiotic spindle assembly checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in meiotic spindle assembly checkpoint" EXACT [GOC:mah] +is_a: GO:0072410 ! response to meiotic cell cycle checkpoint signaling +is_a: GO:0072485 ! response to spindle assembly checkpoint signaling + +[Term] +id: GO:0072466 +name: obsolete detection of stimulus involved in cell shape checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about aspects of cell polarity control is received and converted into a molecular signal, contributing to a cell shape checkpoint." [GOC:mah, GOC:mtg_cell_cycle] +comment: This term was made obsolete because it was ambiguous. +synonym: "cell shape checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "cell shape checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in cell shape checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072467 +name: obsolete response to cell shape checkpoint signaling +namespace: biological_process +def: "OBSOLETE. A process that occurs in response to signals generated as a result of cell shape checkpoint signaling." [GOC:mtg_cell_cycle] +comment: This term was made obsolete because it was ambiguous. +synonym: "cell shape checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in cell shape checkpoint" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072468 +name: obsolete signal transduction involved in cell shape checkpoint +namespace: biological_process +def: "OBSOLETE. A signal transduction process that contributes to a cell shape checkpoint." [GOC:mah] +comment: This term was made obsolete because it was ambiguous. +is_obsolete: true + +[Term] +id: GO:0072469 +name: obsolete detection of stimulus involved in cell size control checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about cell size is received and converted into a molecular signal, contributing to a cell size control checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "cell size control checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "cell size control checkpoint sensor process" RELATED [GOC:mah] +synonym: "detection of stimulus involved in mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] +synonym: "sensing involved in cell size control checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072470 +name: response to cell size control checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of cell size control checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "cell size control checkpoint effector process" EXACT [GOC:mah] +synonym: "response to mitotic cell cycle cell size control checkpoint signaling" EXACT [GOC:mah] +synonym: "response to signal involved in cell size control checkpoint" EXACT [GOC:mah] +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling + +[Term] +id: GO:0072475 +name: obsolete detection of stimulus involved in mitotic spindle checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in mitotic cell cycle spindle checkpoint" EXACT [] +synonym: "mitotic cell cycle spindle checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle spindle checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle spindle checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072476 +name: response to mitotic spindle checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah] +synonym: "response to mitotic cell cycle spindle checkpoint signaling" EXACT [] +synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah] +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling +is_a: GO:0072417 ! response to spindle checkpoint signaling + +[Term] +id: GO:0072478 +name: obsolete detection of stimulus involved in mitotic spindle assembly checkpoint +namespace: biological_process +alt_id: GO:1902419 +def: "OBSOLETE. The series of events in which information about whether the spindle is correctly assembled, and chromosomes are attached to the spindle, is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle assembly checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in Dma1-dependent checkpoint" NARROW [] +synonym: "detection of stimulus involved in mitotic cell cycle spindle assembly checkpoint" EXACT [] +synonym: "detection of stimulus involved in SAC-independent checkpoint" EXACT [GOC:TermGenie] +synonym: "mitotic cell cycle spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle spindle assembly checkpoint sensor process" RELATED [GOC:mah] +synonym: "perception of stimulus involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "perception of stimulus involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] +synonym: "sensing involved in mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:mah] +synonym: "stimulus detection involved in DMA1-dependent checkpoint" NARROW [GOC:TermGenie] +synonym: "stimulus detection involved in SAC-independent checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in DMA1-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus sensing involved in SAC-independent checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:0072479 +name: response to mitotic cell cycle spindle assembly checkpoint signaling +namespace: biological_process +alt_id: GO:0044811 +def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle spindle assembly checkpoint effector process" EXACT [GOC:mah] +synonym: "response to Dma1-dependent checkpoint signaling" NARROW [] +synonym: "response to Dma1-dependent checkpoint signalling" NARROW [] +synonym: "response to signal involved in mitotic cell cycle spindle assembly checkpoint" EXACT [GOC:mah] +is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling +is_a: GO:0072485 ! response to spindle assembly checkpoint signaling + +[Term] +id: GO:0072481 +name: obsolete detection of stimulus involved in mitotic spindle orientation checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether the spindle is correctly oriented is received and converted into a molecular signal, contributing to a mitotic cell cycle spindle orientation checkpoint." [GOC:mtg_cell_cycle] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in mitotic cell cycle spindle orientation checkpoint" EXACT [] +synonym: "mitotic cell cycle spindle orientation checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "mitotic cell cycle spindle orientation checkpoint sensor process" RELATED [GOC:mah] +synonym: "sensing involved in mitotic cell cycle spindle orientation checkpoint" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072482 +name: response to mitotic cell cycle spindle orientation checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "mitotic cell cycle spindle orientation checkpoint effector process" EXACT [GOC:mah] +synonym: "response to signal involved in mitotic cell cycle spindle orientation checkpoint" EXACT [GOC:mah] +is_a: GO:0072476 ! response to mitotic spindle checkpoint signaling + +[Term] +id: GO:0072484 +name: obsolete detection of stimulus involved in spindle assembly checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about spindle assembly is received and converted into a molecular signal, contributing to a spindle assembly checkpoint." [GOC:mah] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "sensing involved in spindle assembly checkpoint" RELATED [GOC:mah] +synonym: "spindle assembly checkpoint sensor mechanism" RELATED [GOC:mah] +synonym: "spindle assembly checkpoint sensor process" RELATED [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072485 +name: response to spindle assembly checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling." [GOC:mtg_cell_cycle] +synonym: "response to signal involved in spindle assembly checkpoint" EXACT [GOC:mah] +synonym: "spindle assembly checkpoint effector process" EXACT [GOC:mah] +is_a: GO:0072417 ! response to spindle checkpoint signaling + +[Term] +id: GO:0072487 +name: MSL complex +namespace: cellular_component +def: "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3." [PMID:16227571, PMID:20018852] +is_a: GO:1902562 ! H4 histone acetyltransferase complex + +[Term] +id: GO:0072488 +name: ammonium transmembrane transport +namespace: biological_process +alt_id: GO:0015696 +def: "The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "ammonia transport" BROAD [] +synonym: "ammonium membrane transport" EXACT [] +synonym: "ammonium transport" BROAD [] +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0072489 +name: methylammonium transmembrane transport +namespace: biological_process +def: "The process in which methylammonium is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "methylammonium membrane transport" EXACT [] +is_a: GO:0015843 ! methylammonium transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:0072490 +name: toluene-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving toluene, methylbenzene (formula C7H8), or any of its derivatives." [GOC:mah] +synonym: "toluene and derivative metabolic process" EXACT [GOC:mah] +synonym: "toluene-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:0072491 +name: toluene-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives." [GOC:mah] +synonym: "toluene and derivative catabolic process" EXACT [GOC:mah] +synonym: "toluene-containing compound breakdown" EXACT [GOC:mah] +synonym: "toluene-containing compound catabolism" EXACT [GOC:mah] +synonym: "toluene-containing compound degradation" EXACT [GOC:mah] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072490 ! toluene-containing compound metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:0072492 +name: host cell mitochondrial intermembrane space +namespace: cellular_component +def: "The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope." [GOC:ecd] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0044190 ! host cell mitochondrial envelope + +[Term] +id: GO:0072493 +name: host cell endosome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the host cell endosome." [GOC:ecd] +synonym: "host endosome lumen" EXACT [GOC:mah] +is_a: GO:0033655 ! host cell cytoplasm part +relationship: part_of GO:0044174 ! host cell endosome + +[Term] +id: GO:0072494 +name: host multivesicular body +namespace: cellular_component +def: "A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm." [GOC:rph] +synonym: "host cell multivesicular body" EXACT [GOC:mah] +is_a: GO:0044184 ! host cell late endosome + +[Term] +id: GO:0072495 +name: host cell Cajal body +namespace: cellular_component +def: "A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:rph] +synonym: "coiled body of host" EXACT [GOC:rph] +synonym: "host cell coiled body" EXACT [GOC:mah] +is_a: GO:0044094 ! host cell nuclear part +relationship: part_of GO:0044095 ! host cell nucleoplasm + +[Term] +id: GO:0072496 +name: Pup transferase activity +namespace: molecular_function +def: "Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages." [GOC:sp] +synonym: "Pup conjugating enzyme activity" NARROW [GOC:mah] +is_a: GO:0019787 ! ubiquitin-like protein transferase activity + +[Term] +id: GO:0072497 +name: mesenchymal stem cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0002452, GOC:BHF] +is_a: GO:0048863 ! stem cell differentiation + +[Term] +id: GO:0072498 +name: embryonic skeletal joint development +namespace: biological_process +def: "The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure." [GOC:BHF, GOC:vk] +is_a: GO:0048706 ! embryonic skeletal system development + +[Term] +id: GO:0072499 +name: photoreceptor cell axon guidance +namespace: biological_process +def: "The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues." [GOC:sart, PMID:20826677] +synonym: "photoreceptor cell axon pathfinding" EXACT [GOC:mah] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0072500 +name: obsolete negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor +namespace: biological_process +def: "OBSOLETE. Any process in which a ligand-bound hormone receptor acts in the nucleus to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:mah] +comment: This term was made obsolete because it is unclear whether the term represents the action of the receptor or the entire process of transcription regulation. The term 'nuclear hormone receptor' is also misleading since many of these receptors reside in the cytoplasm until they are bound by a ligand. +synonym: "negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0004879 +consider: GO:0030374 +consider: GO:0030522 + +[Term] +id: GO:0072501 +name: cellular divalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell." [GOC:mah] +comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular trivalent inorganic anion homeostasis' ; GO:0072502'). +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:0072505 ! divalent inorganic anion homeostasis + +[Term] +id: GO:0072502 +name: cellular trivalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell." [GOC:mah] +comment: Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular divalent inorganic anion homeostasis' ; GO:0072501'). +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:0072506 ! trivalent inorganic anion homeostasis + +[Term] +id: GO:0072503 +name: cellular divalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell." [GOC:mah] +comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504'). +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0072507 ! divalent inorganic cation homeostasis + +[Term] +id: GO:0072504 +name: cellular trivalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell." [GOC:mah] +comment: Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular divalent inorganic cation homeostasis' ; GO:0072503'). +is_a: GO:0030003 ! cellular cation homeostasis +is_a: GO:0072508 ! trivalent inorganic cation homeostasis + +[Term] +id: GO:0072505 +name: divalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell." [GOC:mah] +comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506'). +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0072506 +name: trivalent inorganic anion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell." [GOC:mah] +comment: Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505'). +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0072507 +name: divalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell." [GOC:mah] +comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0072508 +name: trivalent inorganic cation homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell." [GOC:mah] +comment: Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'divalent inorganic cation homeostasis' ; GO:0072507'). +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0098771 ! inorganic ion homeostasis + +[Term] +id: GO:0072513 +name: positive regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:BHF, GOC:mah, GOC:rl] +synonym: "negative regulation of second heart field cardioblast proliferation" EXACT [GOC:mah] +is_a: GO:0003266 ! regulation of secondary heart field cardioblast proliferation +is_a: GO:0008284 ! positive regulation of cell population proliferation + +[Term] +id: GO:0072514 +name: trehalose transport in response to water deprivation +namespace: biological_process +def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water." [GOC:mah] +is_a: GO:0015771 ! trehalose transport +relationship: part_of GO:0042631 ! cellular response to water deprivation + +[Term] +id: GO:0072515 +name: trehalose transport in response to desiccation +namespace: biological_process +def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water." [GOC:mah] +is_a: GO:0072514 ! trehalose transport in response to water deprivation +relationship: part_of GO:0071465 ! cellular response to desiccation + +[Term] +id: GO:0072517 +name: host cell viral assembly compartment +namespace: cellular_component +alt_id: GO:0072516 +def: "A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place." [GOC:BHF, PMID:20374631] +synonym: "host cell viral assembly site" RELATED [GOC:BHF] +synonym: "host cell virion assembly compartment" EXACT [GOC:mah] +synonym: "viral assembly compartment" EXACT [] +synonym: "viral assembly site" RELATED [] +synonym: "virion assembly compartment" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0039714 ! cytoplasmic viral factory + +[Term] +id: GO:0072518 +name: Rho-dependent protein serine/threonine kinase activity +namespace: molecular_function +def: "Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein." [GOC:ecd, PMID:12778124, PMID:20230755] +comment: This reaction requires binding of the GTPase Rho. +synonym: "Rho-associated protein kinase activity" EXACT [GOC:ecd] +synonym: "ROCK kinase activity" EXACT [GOC:ecd] +is_a: GO:0004674 ! protein serine/threonine kinase activity + +[Term] +id: GO:0072520 +name: seminiferous tubule development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa." [GOC:BHF, GOC:mah, UBERON:0001343] +is_a: GO:0035295 ! tube development +is_a: GO:0048608 ! reproductive structure development +relationship: part_of GO:0008584 ! male gonad development + +[Term] +id: GO:0072521 +name: purine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] +synonym: "purine and derivative metabolic process" EXACT [] +synonym: "purine-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0072522 +name: purine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] +synonym: "purine and derivative biosynthetic process" EXACT [] +synonym: "purine-containing compound anabolism" EXACT [GOC:mah] +synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] +synonym: "purine-containing compound formation" EXACT [GOC:mah] +synonym: "purine-containing compound synthesis" EXACT [GOC:mah] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0072521 ! purine-containing compound metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0072523 +name: purine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [GOC:mah] +synonym: "purine and derivative catabolic process" EXACT [] +synonym: "purine-containing compound breakdown" EXACT [GOC:mah] +synonym: "purine-containing compound catabolism" EXACT [GOC:mah] +synonym: "purine-containing compound degradation" EXACT [GOC:mah] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072521 ! purine-containing compound metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0072524 +name: pyridine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] +synonym: "pyridine and derivative metabolic process" EXACT [] +synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0072525 +name: pyridine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] +synonym: "pyridine and derivative biosynthetic process" EXACT [] +synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah] +synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah] +synonym: "pyridine-containing compound formation" EXACT [GOC:mah] +synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0072526 +name: pyridine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [GOC:mah] +synonym: "pyridine and derivative catabolic process" EXACT [] +synonym: "pyridine-containing compound breakdown" EXACT [GOC:mah] +synonym: "pyridine-containing compound catabolism" EXACT [GOC:mah] +synonym: "pyridine-containing compound degradation" EXACT [GOC:mah] +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0072527 +name: pyrimidine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah] +synonym: "pyrimidine and derivative metabolic process" EXACT [] +synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah] +is_a: GO:0034641 ! cellular nitrogen compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:0072528 +name: pyrimidine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah] +synonym: "pyrimidine and derivative biosynthetic process" EXACT [] +synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah] +synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah] +synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah] +synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0072529 +name: pyrimidine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah] +synonym: "pyrimidine and derivative catabolic process" EXACT [] +synonym: "pyrimidine-containing compound breakdown" EXACT [GOC:mah] +synonym: "pyrimidine-containing compound catabolism" EXACT [GOC:mah] +synonym: "pyrimidine-containing compound degradation" EXACT [GOC:mah] +is_a: GO:0044270 ! cellular nitrogen compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:0072530 +name: purine-containing compound transmembrane transport +namespace: biological_process +def: "The process in which a purine-containing compound is transported across a membrane. A purine-containing compound is any compound that contains purine or a formal derivative thereof." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "purine-containing compound membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0072531 +name: pyrimidine-containing compound transmembrane transport +namespace: biological_process +def: "The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "pyrimidine-containing compound membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0072532 +name: tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives." [GOC:kad, PMID:19779199] +comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986). +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0072533 +name: tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives." [GOC:kad, PMID:19779199] +comment: Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260). +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0072534 +name: perineuronal net +namespace: cellular_component +def: "A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain." [GOC:sl, PMID:18364019] +synonym: "PNN" EXACT [GOC:sl] +is_a: GO:0098966 ! perisynaptic extracellular matrix + +[Term] +id: GO:0072535 +name: tumor necrosis factor (ligand) superfamily member 11 production +namespace: biological_process +def: "The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "RANKL production" EXACT [GOC:ebc, PR:000002107] +synonym: "TNFSF11 production" EXACT [GOC:mah, PR:000002107] +synonym: "tumor necrosis factor ligand superfamily member 11 production" EXACT [GOC:bf, PR:000002107] +is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:0072536 +name: interleukin-23 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits." [GOC:BHF, GOC:mah, PMID:12023369] +synonym: "IL-23 receptor complex" EXACT [GOC:mah] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0072537 +name: fibroblast activation +namespace: biological_process +def: "A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [CL:0000057, GOC:BHF, GOC:mah] +is_a: GO:0001775 ! cell activation + +[Term] +id: GO:0072538 +name: T-helper 17 type immune response +namespace: biological_process +def: "An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22." [GOC:BHF, GOC:ebc] +synonym: "Th17 immune response" EXACT [GOC:mah] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains + +[Term] +id: GO:0072539 +name: T-helper 17 cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] +comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. +synonym: "T-helper 17 cell development" RELATED [GOC:mah] +is_a: GO:0042093 ! T-helper cell differentiation +relationship: part_of GO:0072538 ! T-helper 17 type immune response + +[Term] +id: GO:0072540 +name: T-helper 17 cell lineage commitment +namespace: biological_process +def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17." [CL:0000899, GOC:BHF, GOC:ebc] +synonym: "T-helper 17 cell fate commitment" EXACT [GOC:mah] +synonym: "Th17 cell lineage commitment" EXACT [CL:0000899, GOC:mah] +synonym: "Th17 fate commitment" EXACT [CL:0000899] +is_a: GO:0002295 ! T-helper cell lineage commitment +relationship: part_of GO:0072539 ! T-helper 17 cell differentiation + +[Term] +id: GO:0072541 +name: peroxynitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O." [GOC:rs, PMID:11001062] +comment: Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent. +synonym: "peroxynitritase activity" EXACT [GOC:rs] +is_a: GO:0051920 ! peroxiredoxin activity + +[Term] +id: GO:0072542 +name: protein phosphatase activator activity +namespace: molecular_function +alt_id: GO:0071862 +alt_id: GO:0072543 +def: "Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:mah] +synonym: "protein phosphatase 2 activator activity" NARROW [GOC:dph, GOC:rl] +synonym: "protein phosphatase type 1 activator activity" NARROW [] +synonym: "protein phosphatase type 2A activator activity" NARROW [] +is_a: GO:0019211 ! phosphatase activator activity +is_a: GO:0019888 ! protein phosphatase regulator activity + +[Term] +id: GO:0072544 +name: L-DOPA binding +namespace: molecular_function +def: "Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid." [GOC:mah, GOC:vw] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0072341 ! modified amino acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0072545 +name: tyrosine binding +namespace: molecular_function +def: "Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:mah] +synonym: "Tyr binding" EXACT [GOC:mah] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0072546 +name: EMC complex +namespace: cellular_component +def: "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6." [PMID:29242231, PMID:30415835, PMID:32459176] +comment: Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect. +synonym: "endoplasmic reticulum membrane protein complex" BROAD [] +synonym: "ER membrane protein complex" BROAD [GOC:mah] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane + +[Term] +id: GO:0072547 +name: tricoumaroylspermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +synonym: "tricoumaroyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] +xref: MetaCyc:RXN-11260 +is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072548 +name: dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072549 +name: monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +is_a: GO:0072533 ! tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072550 +name: triferuloylspermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +synonym: "triferuloyl spermidine meta-hydroxylase activity" EXACT [GOC:mah] +xref: MetaCyc:RXN-11262 +is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072551 +name: diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072552 +name: monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O." [GOC:kad, PMID:19779199] +is_a: GO:0072532 ! tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity + +[Term] +id: GO:0072553 +name: terminal button organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:BHF, GOC:mah] +synonym: "bouton organization" EXACT [GOC:mah] +synonym: "presynaptic bouton organization" EXACT [GOC:mah] +synonym: "synaptic bouton organization" EXACT [GOC:mah] +synonym: "terminal bouton organization" EXACT [GOC:mah] +synonym: "terminal button organisation" EXACT [GOC:mah] +is_a: GO:0099172 ! presynapse organization + +[Term] +id: GO:0072554 +name: blood vessel lumenization +namespace: biological_process +def: "The process in which a developing blood vessel forms an endothelial lumen through which blood will flow." [GOC:dsf, PMID:16799567, PMID:20926893] +is_a: GO:0061154 ! endothelial tube morphogenesis +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:0072555 +name: 17-beta-ketosteroid reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+." [GOC:kad, PMID:17074428] +synonym: "17-beta-ketosteroid reductase (NADPH) activity" EXACT [GOC:kad] +synonym: "7beta-ketosteroid reductase activity" EXACT [GOC:kad] +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0072557 +name: IPAF inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0072558 +name: NLRP1 inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] +synonym: "NALP1 inflammasome complex" EXACT [] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0072559 +name: NLRP3 inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus." [GOC:add, GOC:BHF, GOC:vp, PMID:20303873] +synonym: "NALP3 inflammasome complex" EXACT [] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0072560 +name: type B pancreatic cell maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF] +comment: These processes continue to 60 DPA in Gossypium spp. +synonym: "pancreatic B cell maturation" EXACT [CL:0000169, GOC:mah] +synonym: "pancreatic beta cell maturation" EXACT [CL:0000169, GOC:mah] +is_a: GO:0002071 ! glandular epithelial cell maturation +relationship: part_of GO:0003323 ! type B pancreatic cell development + +[Term] +id: GO:0072562 +name: blood microparticle +namespace: cellular_component +def: "A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids." [GOC:BHF, GOC:mah, PMID:16373184] +synonym: "cell membrane microparticle" EXACT [PMID:16373184] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0072563 +name: endothelial microparticle +namespace: cellular_component +def: "A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] +is_a: GO:0072562 ! blood microparticle + +[Term] +id: GO:0072564 +name: blood microparticle formation +namespace: biological_process +def: "The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell." [GOC:BHF, GOC:mah, PMID:16373184] +synonym: "microparticle generation" EXACT [PMID:20978343] +synonym: "microparticle release" EXACT [PMID:16373184] +is_a: GO:0016043 ! cellular component organization +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0072565 +name: endothelial microparticle formation +namespace: biological_process +def: "The cellular component organization process in which microparticles bud off from an endothelial cell." [GOC:BHF, GOC:mah, PMID:16373184] +synonym: "endothelial microparticle generation" EXACT [GOC:mah, PMID:20978343] +synonym: "endothelial microparticle release" EXACT [GOC:mah, PMID:16373184] +is_a: GO:0072564 ! blood microparticle formation + +[Term] +id: GO:0072566 +name: chemokine (C-X-C motif) ligand 1 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] +subset: gocheck_do_not_annotate +synonym: "CXCL1 production" EXACT [GOC:BHF] +synonym: "KC production" EXACT [GOC:BHF] +synonym: "keratinocyte derived chemokine production" EXACT [GOC:BHF] +synonym: "SCYB1 production" EXACT [GOC:BHF] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0072567 +name: chemokine (C-X-C motif) ligand 2 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah] +subset: gocheck_do_not_annotate +synonym: "CXCL2 production" EXACT [GOC:mah] +synonym: "MIP-2 production" EXACT [GOC:BHF] +synonym: "MIP2 production" EXACT [GOC:BHF] +synonym: "SCYB2 production" EXACT [GOC:BHF] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0072570 +name: ADP-D-ribose binding +namespace: molecular_function +def: "Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [GOC:mah, GOC:sart, PMID:20088964] +synonym: "ADP-ribose binding" BROAD [GOC:mah] +is_a: GO:0043168 ! anion binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:0097367 ! carbohydrate derivative binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0072571 +name: mono-ADP-D-ribose binding +namespace: molecular_function +def: "Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment." [GOC:mah, GOC:sart, PMID:20088964] +synonym: "mADPr binding" EXACT [PMID:20088964] +synonym: "mono-ADP-ribose binding" BROAD [GOC:mah] +is_a: GO:0072570 ! ADP-D-ribose binding + +[Term] +id: GO:0072572 +name: poly-ADP-D-ribose binding +namespace: molecular_function +def: "Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring." [GOC:mah, GOC:sart, PMID:20088964] +synonym: "pADPr binding" EXACT [PMID:20088964] +synonym: "poly-ADP-ribose binding" BROAD [GOC:mah] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0072573 +name: tolerance induction to lipopolysaccharide +namespace: biological_process +def: "Tolerance induction directed at lipopolysaccharide antigens." [GOC:BHF, GOC:mah] +synonym: "tolerance induction to endotoxin" BROAD [GOC:add, GOC:mah] +synonym: "tolerance induction to LPS" EXACT [GOC:add, GOC:mah] +is_a: GO:0002507 ! tolerance induction +is_a: GO:0031665 ! negative regulation of lipopolysaccharide-mediated signaling pathway +relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide + +[Term] +id: GO:0072574 +name: hepatocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules." [CL:0000182, GOC:BHF, GOC:mah] +is_a: GO:0072575 ! epithelial cell proliferation involved in liver morphogenesis + +[Term] +id: GO:0072575 +name: epithelial cell proliferation involved in liver morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver." [GOC:BHF, GOC:mah] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0072576 ! liver morphogenesis + +[Term] +id: GO:0072576 +name: liver morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the liver are generated and organized." [GOC:mah] +is_a: GO:0022612 ! gland morphogenesis +relationship: part_of GO:0001889 ! liver development + +[Term] +id: GO:0072577 +name: endothelial cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal." [CL:0000115, GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +synonym: "apoptosis of endothelial cells" EXACT [GOC:mah] +synonym: "endothelial cell apoptosis" NARROW [] +synonym: "endothelial cell programmed cell death by apoptosis" EXACT [GOC:mah] +synonym: "killing of endothelial cells" EXACT [GOC:mah] +synonym: "programmed cell death of endothelial cells by apoptosis" EXACT [GOC:mah] +synonym: "programmed cell death, endothelial cells" EXACT [GOC:mah] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:0072578 +name: neurotransmitter-gated ion channel clustering +namespace: biological_process +def: "The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane." [GOC:dsf, PMID:20843816] +is_a: GO:0043113 ! receptor clustering +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0072579 +name: glycine receptor clustering +namespace: biological_process +def: "The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane." [GOC:dsf, GOC:mah, GOC:pr, PMID:20843816] +is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering +relationship: part_of GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:0072580 +name: bacterial-type EF-P lysine modification +namespace: biological_process +def: "The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P)." [GOC:curators, GOC:imk, GOC:mah, PMID:20729861, PMID:22706199, RESID:AA0530, RESID:AA0531] +comment: The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34. +synonym: "EF-P modification pathway" EXACT [PMID:22706199] +is_a: GO:0018205 ! peptidyl-lysine modification + +[Term] +id: GO:0072581 +name: protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine +namespace: biological_process +def: "The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P)." [GOC:jsg, GOC:mah, PMID:20729861, RESID:AA0531] +is_a: GO:0018205 ! peptidyl-lysine modification +relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification + +[Term] +id: GO:0072582 +name: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+." [GOC:kad, PMID:17074428] +is_a: GO:0004303 ! estradiol 17-beta-dehydrogenase activity + +[Term] +id: GO:0072583 +name: clathrin-dependent endocytosis +namespace: biological_process +def: "An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles." [GOC:BHF, GOC:mah, PMID:18498251, PMID:8970738, PMID:9234965] +synonym: "clathrin coated pit-dependent endocytosis" EXACT [GOC:BHF] +synonym: "clathrin-mediated endocytosis" EXACT [] +synonym: "CME" EXACT [PMID:20074057] +is_a: GO:0006898 ! receptor-mediated endocytosis + +[Term] +id: GO:0072584 +name: caveolin-mediated endocytosis +namespace: biological_process +def: "An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers." [GOC:BHF, GOC:mah, PMID:17318224, PMID:18498251, PMID:8970738, PMID:9234965] +synonym: "caveolae-dependent endocytosis" EXACT [GOC:mah] +synonym: "caveolae-mediated endocytosis" EXACT [GOC:mah] +synonym: "caveolin-dependent endocytosis" EXACT [GOC:BHF] +is_a: GO:0006897 ! endocytosis + +[Term] +id: GO:0072585 +name: xanthosine nucleotidase activity +namespace: molecular_function +def: "Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine." [GOC:kad, MetaCyc:RXN0-363, PMID:21235647] +synonym: "xanthosine ribohydrolase activity" EXACT [GOC:kad] +xref: MetaCyc:RXN0-363 +xref: RHEA:27994 +is_a: GO:0008477 ! purine nucleosidase activity + +[Term] +id: GO:0072586 +name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] +is_a: GO:0030234 ! enzyme regulator activity +is_a: GO:0060590 ! ATPase regulator activity + +[Term] +id: GO:0072587 +name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity +namespace: molecular_function +def: "Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] +is_a: GO:0001671 ! ATPase activator activity +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity + +[Term] +id: GO:0072588 +name: box H/ACA RNP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex." [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:krc, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365] +synonym: "box H/ACA snoRNP pseudouridylase complex" RELATED [GOC:mah] +synonym: "sRNP complex" NARROW [GOC:mah, PMID:17284456, PMID:20227365] +is_a: GO:0005732 ! sno(s)RNA-containing ribonucleoprotein complex + +[Term] +id: GO:0072589 +name: box H/ACA scaRNP complex +namespace: cellular_component +def: "A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs." [GOC:mah, PMID:17284456, PMID:20227365] +synonym: "nucleoplasmic box H/ACA RNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:20227365] +is_a: GO:0072588 ! box H/ACA RNP complex +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0015030 ! Cajal body + +[Term] +id: GO:0072590 +name: N-acetyl-L-aspartate-L-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate." [PMID:20643647, PMID:20657015] +xref: Reactome:R-HSA-8942575 "N-acetylaspartylglutamate synthase A ligates NAA, L-Glu forming NAAG" +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0072591 +name: citrate-L-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate." [PMID:20657015] +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0072592 +name: oxygen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diatomic oxygen (O2)." [GOC:mah] +synonym: "diatomic oxygen metabolic process" EXACT [CHEBI:33263] +synonym: "oxygen metabolism" EXACT [GOC:mah] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0072593 +name: reactive oxygen species metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [GOC:mah] +synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] +synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0072594 +name: establishment of protein localization to organelle +namespace: biological_process +def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] +synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle +is_a: GO:0045184 ! establishment of protein localization + +[Term] +id: GO:0072595 +name: maintenance of protein localization in organelle +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] +synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah] +synonym: "maintenance of protein localization to organelle" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0072596 +name: establishment of protein localization to chloroplast +namespace: biological_process +def: "The directed movement of a protein to a specific location in a chloroplast." [GOC:mah] +synonym: "establishment of protein localisation to chloroplast" EXACT [GOC:mah] +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0072598 ! protein localization to chloroplast + +[Term] +id: GO:0072597 +name: maintenance of protein location in chloroplast +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0072598 ! protein localization to chloroplast + +[Term] +id: GO:0072598 +name: protein localization to chloroplast +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location in a chloroplast." [GOC:ecd] +synonym: "protein localisation to chloroplast" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0072599 +name: establishment of protein localization to endoplasmic reticulum +namespace: biological_process +def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah] +synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah] +synonym: "establishment of protein localisation to ER" EXACT [GOC:mah] +synonym: "establishment of protein localization in endoplasmic reticulum" EXACT [] +synonym: "establishment of protein localization to ER" EXACT [GOC:mah] +is_a: GO:0070972 ! protein localization to endoplasmic reticulum +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0072627 +name: interleukin-28A production +namespace: biological_process +alt_id: GO:0072628 +def: "The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IL-28A production" EXACT [GOC:BHF] +synonym: "IL28A production" EXACT [GOC:BHF] +synonym: "interferon lambda 2 production" EXACT [GOC:BHF] +synonym: "interleukin-28A secretion" NARROW [] +is_a: GO:0034343 ! type III interferon production + +[Term] +id: GO:0072629 +name: interleukin-28B production +namespace: biological_process +alt_id: GO:0072630 +def: "The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IL-28B production" EXACT [GOC:BHF] +synonym: "IL28B production" EXACT [GOC:BHF] +synonym: "interferon lambda 3 production" EXACT [GOC:BHF] +synonym: "interleukin-28B secretion" NARROW [] +is_a: GO:0034343 ! type III interferon production + +[Term] +id: GO:0072631 +name: interleukin-29 production +namespace: biological_process +alt_id: GO:0072632 +def: "The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IL-29 production" EXACT [GOC:BHF] +synonym: "IL29 production" EXACT [GOC:BHF] +synonym: "interferon lambda 1 production" EXACT [GOC:BHF] +synonym: "interleukin-29 secretion" NARROW [] +is_a: GO:0034343 ! type III interferon production + +[Term] +id: GO:0072633 +name: interleukin-30 production +namespace: biological_process +alt_id: GO:0072634 +def: "The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +subset: gocheck_do_not_annotate +synonym: "IL-30 production" EXACT [GOC:BHF] +synonym: "interleukin-30 complex production" EXACT [GOC:BHF] +synonym: "interleukin-30 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0072635 +name: interleukin-31 production +namespace: biological_process +alt_id: GO:0072636 +def: "The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, http://www.copewithcytokines.de/cope.cgi?key=interleukins] +subset: gocheck_do_not_annotate +synonym: "IL-31 production" EXACT [GOC:BHF] +synonym: "interleukin-31 secretion" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0072637 +name: interleukin-32 production +namespace: biological_process +alt_id: GO:0072638 +alt_id: GO:0150188 +def: "The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:23729669] +subset: gocheck_do_not_annotate +synonym: "IL-32 production" EXACT [GOC:BHF] +synonym: "IL32 production" EXACT [GOC:BHF] +synonym: "interleukin-32 biosynthetic process" NARROW [] +synonym: "interleukin-32 secretion" NARROW [] +synonym: "NK4 production" NARROW [GOC:BHF] +synonym: "TAIF production" NARROW [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0072639 +name: interleukin-33 production +namespace: biological_process +alt_id: GO:0072640 +alt_id: GO:0150126 +def: "The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:29778524] +subset: gocheck_do_not_annotate +synonym: "C9orf26 production" NARROW [GOC:BHF] +synonym: "IL-33 production" EXACT [GOC:BHF] +synonym: "IL1F11 production" NARROW [GOC:BHF] +synonym: "IL33 production" EXACT [GOC:BHF] +synonym: "interleukin-33 biosynthetic process" NARROW [] +synonym: "interleukin-33 secretion" NARROW [] +synonym: "NF-HEV production" EXACT [GOC:BHF] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0072645 +name: interferon-delta production +namespace: biological_process +alt_id: GO:0072646 +def: "The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-delta production" EXACT [GOC:mah] +synonym: "IFND production" EXACT [GOC:BHF] +synonym: "interferon-delta secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0072647 +name: interferon-epsilon production +namespace: biological_process +alt_id: GO:0072648 +def: "The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-epsilon production" EXACT [GOC:mah] +synonym: "IFNE production" EXACT [GOC:BHF] +synonym: "interferon-epsilon secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0072649 +name: interferon-kappa production +namespace: biological_process +alt_id: GO:0072650 +def: "The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-kappa production" EXACT [GOC:mah] +synonym: "IFNK production" EXACT [GOC:BHF] +synonym: "interferon-kappa secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0072651 +name: interferon-tau production +namespace: biological_process +alt_id: GO:0072652 +def: "The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-tau production" EXACT [GOC:mah] +synonym: "IFN-tau secretion" EXACT [GOC:mah] +synonym: "IFNT production" EXACT [GOC:BHF] +synonym: "interferon-tau secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0072653 +name: interferon-omega production +namespace: biological_process +alt_id: GO:0072654 +def: "The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:mah, PMID:15546383] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "IFN-omega production" EXACT [GOC:mah] +synonym: "IFNW production" EXACT [GOC:BHF] +synonym: "interferon-omega secretion" NARROW [] +is_a: GO:0032606 ! type I interferon production + +[Term] +id: GO:0072655 +name: establishment of protein localization to mitochondrion +namespace: biological_process +def: "The directed movement of a protein to the mitochondrion or a part of the mitochondrion." [GOC:mah] +synonym: "establishment of protein localisation to mitochondrion" EXACT [GOC:mah] +synonym: "establishment of protein localization in mitochondrion" EXACT [] +is_a: GO:0070585 ! protein localization to mitochondrion +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0072656 +name: maintenance of protein location in mitochondrion +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0070585 ! protein localization to mitochondrion + +[Term] +id: GO:0072657 +name: protein localization to membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] +synonym: "protein localisation in membrane" EXACT [GOC:mah] +synonym: "protein localization in membrane" EXACT [] +is_a: GO:0034613 ! cellular protein localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0072658 +name: maintenance of protein location in membrane +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0072657 ! protein localization to membrane + +[Term] +id: GO:0072659 +name: protein localization to plasma membrane +namespace: biological_process +alt_id: GO:0072661 +alt_id: GO:0090002 +def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] +subset: goslim_generic +subset: goslim_pombe +synonym: "protein localisation in plasma membrane" RELATED [GOC:mah] +synonym: "protein localization in plasma membrane" RELATED [] +synonym: "protein targeting to plasma membrane" RELATED [] +synonym: "protein-plasma membrane targeting" RELATED [GOC:mah] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0072660 +name: maintenance of protein location in plasma membrane +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072658 ! maintenance of protein location in membrane +relationship: part_of GO:0072659 ! protein localization to plasma membrane + +[Term] +id: GO:0072662 +name: protein localization to peroxisome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome." [GOC:ecd] +synonym: "protein localisation to peroxisome" EXACT [GOC:mah] +is_a: GO:0007031 ! peroxisome organization +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0072663 +name: establishment of protein localization to peroxisome +namespace: biological_process +def: "The directed movement of a protein to a specific location in a peroxisome." [GOC:mah] +synonym: "establishment of protein localisation to peroxisome" EXACT [GOC:mah] +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0072662 ! protein localization to peroxisome + +[Term] +id: GO:0072664 +name: maintenance of protein location in peroxisome +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0072662 ! protein localization to peroxisome + +[Term] +id: GO:0072665 +name: protein localization to vacuole +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] +synonym: "protein localisation to vacuole" EXACT [GOC:mah] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0072666 +name: establishment of protein localization to vacuole +namespace: biological_process +def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] +synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0072665 ! protein localization to vacuole + +[Term] +id: GO:0072667 +name: maintenance of protein location in vacuole +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072595 ! maintenance of protein localization in organelle +relationship: part_of GO:0072665 ! protein localization to vacuole + +[Term] +id: GO:0072668 +name: obsolete tubulin complex biogenesis +namespace: biological_process +def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a tubulin complex. Includes the synthesis and folding of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex. A tubulin complex is a heterodimer of tubulins alpha and beta, from which microtubules are assembled." [GOC:mah] +comment: This term was obsoleted because biogenesis should only be used for complexes where synthesis of some non-protein component is necessary for assembly. +synonym: "tubulin complex biogenesis" EXACT [] +is_obsolete: true +replaced_by: GO:0007021 + +[Term] +id: GO:0072669 +name: tRNA-splicing ligase complex +namespace: cellular_component +def: "A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester." [GOC:sp, PMID:21311021] +synonym: "tRNA splicing ligase complex" EXACT [GOC:mah] +xref: MetaCyc:ENTMULTI-CPLX +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:0072670 +name: mitochondrial tRNA threonylcarbamoyladenosine modification +namespace: biological_process +def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base)." [GOC:mcc, PMID:21183954] +synonym: "mitochondrial tRNA t6A modification" EXACT [GOC:mcc] +is_a: GO:0002949 ! tRNA threonylcarbamoyladenosine modification +is_a: GO:0070900 ! mitochondrial tRNA modification + +[Term] +id: GO:0072671 +name: mitochondria-associated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions." [GOC:mcc, PMID:21070972, PMID:21109188] +synonym: "MAD" EXACT [GOC:mcc] +synonym: "mitochondria-associated protein catabolic process" EXACT [] +synonym: "mitochondria-associated protein degradation" EXACT [GOC:mcc] +synonym: "mitochondrion-associated protein catabolic process" EXACT [GOC:mah] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0072672 +name: neutrophil extravasation +namespace: biological_process +def: "The migration of a neutrophil from the blood vessels into the surrounding tissue." [CL:0000775, GOC:BHF] +is_a: GO:0045123 ! cellular extravasation +is_a: GO:1990266 ! neutrophil migration + +[Term] +id: GO:0072673 +name: lamellipodium morphogenesis +namespace: biological_process +def: "A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized." [GOC:BHF, GOC:mah] +synonym: "lamellipodium organization" RELATED [GOC:mah] +is_a: GO:0097581 ! lamellipodium organization +is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis + +[Term] +id: GO:0072674 +name: multinuclear osteoclast differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000779, GOC:mah, PMID:12713016] +synonym: "multinuclear osteoclast formation" RELATED [GOC:BHF, GOC:mah] +synonym: "multinuclear osteoclast morphogenesis" RELATED [GOC:BHF, GOC:mah] +is_a: GO:0030316 ! osteoclast differentiation + +[Term] +id: GO:0072675 +name: osteoclast fusion +namespace: biological_process +def: "The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast." [CL:0000092, CL:0000779, GOC:BHF, GOC:mah, PMID:12713016] +is_a: GO:0000768 ! syncytium formation by plasma membrane fusion +relationship: part_of GO:0072674 ! multinuclear osteoclast differentiation + +[Term] +id: GO:0072676 +name: lymphocyte migration +namespace: biological_process +def: "The movement of a lymphocyte within or between different tissues and organs of the body." [CL:0000542, GOC:BHF, GOC:mah] +is_a: GO:0071674 ! mononuclear cell migration + +[Term] +id: GO:0072677 +name: eosinophil migration +namespace: biological_process +def: "The movement of an eosinophil within or between different tissues and organs of the body." [CL:0000771, GOC:BHF, GOC:mah] +is_a: GO:0097530 ! granulocyte migration + +[Term] +id: GO:0072678 +name: T cell migration +namespace: biological_process +def: "The movement of a T cell within or between different tissues and organs of the body." [CL:0000084, GOC:BHF, GOC:mah] +synonym: "T lymphocyte migration" EXACT [CL:0000084] +synonym: "T-cell migration" EXACT [CL:0000084] +synonym: "T-lymphocyte migration" EXACT [CL:0000084] +is_a: GO:0072676 ! lymphocyte migration + +[Term] +id: GO:0072679 +name: thymocyte migration +namespace: biological_process +def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development." [CL:0000893, GOC:BHF, GOC:mah] +synonym: "immature T cell migration" RELATED [CL:0000893] +synonym: "immature T lymphocyte migration" RELATED [CL:0000893] +synonym: "immature T-cell migration" RELATED [CL:0000893] +synonym: "immature T-lymphocyte migration" RELATED [CL:0000893] +synonym: "thymic lymphocyte migration" EXACT [CL:0000893] +is_a: GO:0072678 ! T cell migration + +[Term] +id: GO:0072680 +name: extracellular matrix-dependent thymocyte migration +namespace: biological_process +def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] +synonym: "extracellular matrix-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] +synonym: "extracellular matrix-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] +synonym: "extracellular matrix-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] +synonym: "extracellular matrix-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] +synonym: "extracellular matrix-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] +is_a: GO:0006929 ! substrate-dependent cell migration +is_a: GO:0072679 ! thymocyte migration + +[Term] +id: GO:0072681 +name: fibronectin-dependent thymocyte migration +namespace: biological_process +def: "The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix." [CL:0000893, GOC:BHF, GOC:mah, PMID:20856819] +synonym: "fibronectin-dependent immature T cell migration" RELATED [CL:0000893, GOC:mah] +synonym: "fibronectin-dependent immature T lymphocyte migration" RELATED [CL:0000893, GOC:mah] +synonym: "fibronectin-dependent immature T-cell migration" RELATED [CL:0000893, GOC:mah] +synonym: "fibronectin-dependent immature T-lymphocyte migration" RELATED [CL:0000893, GOC:mah] +synonym: "fibronectin-dependent thymic lymphocyte migration" EXACT [CL:0000893, GOC:mah] +is_a: GO:0072680 ! extracellular matrix-dependent thymocyte migration + +[Term] +id: GO:0072682 +name: eosinophil extravasation +namespace: biological_process +def: "The migration of an eosinophil from the blood vessels into the surrounding tissue." [CL:0000771, GOC:BHF, GOC:mah] +is_a: GO:0045123 ! cellular extravasation +is_a: GO:0072677 ! eosinophil migration + +[Term] +id: GO:0072683 +name: T cell extravasation +namespace: biological_process +def: "The migration of a T cell from the blood vessels into the surrounding tissue." [CL:0000084, GOC:BHF, GOC:mah] +synonym: "T lymphocyte extravasation" EXACT [CL:0000084] +synonym: "T-cell extravasation" EXACT [CL:0000084] +synonym: "T-lymphocyte extravasation" EXACT [CL:0000084] +is_a: GO:0045123 ! cellular extravasation +is_a: GO:0072678 ! T cell migration + +[Term] +id: GO:0072684 +name: mitochondrial tRNA 3'-trailer cleavage, endonucleolytic +namespace: biological_process +def: "Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion." [GOC:mah] +synonym: "mitochondrial endonucleolytic tRNA 3'-end cleavage" EXACT [GOC:mah] +synonym: "mitochondrial endonucleolytic tRNA 3'-trailer cleavage" RELATED [GOC:mah] +synonym: "mitochondrial tRNA 3'-end cleavage, endonucleolytic" EXACT [GOC:mah] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic + +[Term] +id: GO:0072685 +name: Mre11 complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838] +synonym: "MRN complex assembly" EXACT [GOC:mah] +synonym: "MRX complex assembly" EXACT [GOC:mah] +synonym: "Rad50 complex assembly" EXACT [GOC:mah] +synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah] +synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah] +synonym: "RMX complex assembly" EXACT [GOC:mah] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0072686 +name: mitotic spindle +namespace: cellular_component +def: "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] +is_a: GO:0005819 ! spindle + +[Term] +id: GO:0072687 +name: meiotic spindle +namespace: cellular_component +def: "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] +is_a: GO:0005819 ! spindle + +[Term] +id: GO:0072688 +name: SHREC complex localization +namespace: biological_process +def: "Any process in which a SHREC complex is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of SHREC complex localization" EXACT [GOC:mah] +synonym: "SHREC complex localisation" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0072689 +name: MCM complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:mah, PMID:21813639] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0072690 +name: single-celled organism vegetative growth phase +namespace: biological_process +alt_id: GO:0062178 +def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +synonym: "stationary phase" NARROW [] +synonym: "vegetative growth of a single-celled organism" EXACT [] +is_a: GO:0044848 ! biological phase + +[Term] +id: GO:0072692 +name: obsolete chromatin silencing at centromere central core +namespace: biological_process +def: "OBSOLETE. Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin." [GOC:mah] +comment: This term was made obsolete because the process does not exist. +synonym: "centromere central core chromatin silencing" EXACT [GOC:mah] +synonym: "chromatin silencing at centromeric central core" EXACT [GOC:vw] +synonym: "chromatin silencing at chromosome kinetochore domain" EXACT [GOC:vw] +synonym: "heterochromatic silencing at centromere central core" EXACT [GOC:mah] +is_obsolete: true + +[Term] +id: GO:0072694 +name: obsolete cell cycle arrest in response to caffeine +namespace: biological_process +def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus." [GOC:mah] +comment: This term was made obsolete because it does not represent a real process. +is_obsolete: true + +[Term] +id: GO:0072695 +name: regulation of DNA recombination at telomere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah] +synonym: "regulation of telomeric recombination" EXACT [GOC:mah] +is_a: GO:0000018 ! regulation of DNA recombination + +[Term] +id: GO:0072696 +name: positive regulation of DNA recombination at telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere." [GOC:mah] +synonym: "activation of telomeric recombination at telomere" NARROW [GOC:mah] +synonym: "positive regulation of telomeric recombination" EXACT [GOC:mah] +synonym: "up regulation of telomeric recombination at telomere" EXACT [GOC:mah] +synonym: "up-regulation of telomeric recombination at telomere" EXACT [GOC:mah] +synonym: "upregulation of telomeric recombination at telomere" EXACT [GOC:mah] +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:0072695 ! regulation of DNA recombination at telomere + +[Term] +id: GO:0072697 +name: protein localization to cell cortex +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] +synonym: "protein localisation to cell cortex" EXACT [GOC:mah] +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0072698 +name: protein localization to microtubule cytoskeleton +namespace: biological_process +def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] +synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] +is_a: GO:0044380 ! protein localization to cytoskeleton + +[Term] +id: GO:0072699 +name: protein localization to cortical microtubule cytoskeleton +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton." [GOC:mah] +synonym: "protein localisation to cortical microtubule cytoskeleton" EXACT [GOC:mah] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:0072698 ! protein localization to microtubule cytoskeleton + +[Term] +id: GO:0072700 +name: response to bismuth +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [GOC:mah] +synonym: "response to bismuth ion" EXACT [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0072701 +name: cellular response to bismuth +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus." [GOC:mah] +synonym: "cellular response to bismuth ion" EXACT [] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0072700 ! response to bismuth + +[Term] +id: GO:0072702 +name: response to methyl methanesulfonate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [GOC:mah] +synonym: "response to MMS" EXACT [CHEBI:25255, GOC:mah] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0072703 +name: cellular response to methyl methanesulfonate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [GOC:mah] +synonym: "cellular response to MMS" EXACT [CHEBI:25255, GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0072702 ! response to methyl methanesulfonate +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072704 +name: response to mercaptoethanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [GOC:mah] +synonym: "response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah] +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0072705 +name: cellular response to mercaptoethanol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus." [GOC:mah] +synonym: "cellular response to 2-sulfanylethanol" EXACT [CHEBI:41218, GOC:mah] +is_a: GO:0072704 ! response to mercaptoethanol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:0072706 +name: response to sodium dodecyl sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [GOC:mah] +synonym: "response to SDS" EXACT [CHEBI:8984, GOC:mah] +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:0072707 +name: cellular response to sodium dodecyl sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus." [GOC:mah] +synonym: "cellular response to SDS" EXACT [CHEBI:8984, GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0072706 ! response to sodium dodecyl sulfate +is_a: GO:1902075 ! cellular response to salt + +[Term] +id: GO:0072708 +name: response to sorbitol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [GOC:mah] +synonym: "response to glucitol" EXACT [CHEBI:30911, GOC:mah] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:0072709 +name: cellular response to sorbitol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [GOC:mah] +synonym: "cellular response to glucitol" EXACT [CHEBI:30911, GOC:mah] +is_a: GO:0071322 ! cellular response to carbohydrate stimulus +is_a: GO:0072708 ! response to sorbitol + +[Term] +id: GO:0072710 +name: response to hydroxyurea +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah] +synonym: "response to HU" EXACT [GOC:mah] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0072711 +name: cellular response to hydroxyurea +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [GOC:mah] +synonym: "cellular response to HU" EXACT [GOC:mah] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0072710 ! response to hydroxyurea +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0072712 +name: response to thiabendazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah] +synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0072713 +name: cellular response to thiabendazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [GOC:mah] +synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0072712 ! response to thiabendazole + +[Term] +id: GO:0072714 +name: response to selenite ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [GOC:mah] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:0072715 +name: cellular response to selenite ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [GOC:mah] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0072714 ! response to selenite ion + +[Term] +id: GO:0072716 +name: response to actinomycin D +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [GOC:mah] +is_a: GO:0046677 ! response to antibiotic +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:0072717 +name: cellular response to actinomycin D +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus." [GOC:mah] +is_a: GO:0071236 ! cellular response to antibiotic +is_a: GO:0072716 ! response to actinomycin D +is_a: GO:1901653 ! cellular response to peptide + +[Term] +id: GO:0072718 +name: response to cisplatin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0072719 +name: cellular response to cisplatin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus." [GOC:mah] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:0072718 ! response to cisplatin + +[Term] +id: GO:0072720 +name: response to dithiothreitol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [GOC:mah] +synonym: "response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah] +synonym: "response to DTT" EXACT [GOC:mah] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0072721 +name: cellular response to dithiothreitol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus." [GOC:mah] +synonym: "cellular response to 1,4-dithiothreitol" EXACT [CHEBI:18320, GOC:mah] +synonym: "cellular response to DTT" EXACT [GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0072720 ! response to dithiothreitol +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072722 +name: response to amitrole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah] +synonym: "response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0072723 +name: cellular response to amitrole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus." [GOC:mah] +synonym: "cellular response to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0072722 ! response to amitrole + +[Term] +id: GO:0072724 +name: response to 4-nitroquinoline N-oxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0072725 +name: cellular response to 4-nitroquinoline N-oxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0072724 ! response to 4-nitroquinoline N-oxide +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072726 +name: response to CCCP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [GOC:mah] +synonym: "response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0072727 +name: cellular response to CCCP +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus." [GOC:mah] +synonym: "cellular response to carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259, GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0072726 ! response to CCCP + +[Term] +id: GO:0072728 +name: response to Gentian violet +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [GOC:mah] +synonym: "response to crystal violet" EXACT [GOC:mah] +synonym: "response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:0072729 +name: cellular response to Gentian violet +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus." [GOC:mah] +synonym: "cellular response to crystal violet" EXACT [GOC:mah] +synonym: "cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:198346, GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0072728 ! response to Gentian violet + +[Term] +id: GO:0072730 +name: response to papulacandin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0072731 +name: cellular response to papulacandin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus." [GOC:mah] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0072730 ! response to papulacandin B +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072732 +name: cellular response to calcium ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions." [GOC:mah] +synonym: "cellular response to calcium starvation" EXACT [GOC:mah] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:0072733 +name: response to staurosporine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043279 ! response to alkaloid + +[Term] +id: GO:0072734 +name: cellular response to staurosporine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus." [GOC:mah] +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0072733 ! response to staurosporine + +[Term] +id: GO:0072735 +name: response to tert-butyl hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah] +synonym: "response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] +synonym: "response to t-BOOH" EXACT [GOC:mah] +is_a: GO:0033195 ! response to alkyl hydroperoxide + +[Term] +id: GO:0072736 +name: cellular response to tert-butyl hydroperoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus." [GOC:mah] +synonym: "cellular response to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] +synonym: "cellular response to t-BOOH" EXACT [GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0071448 ! cellular response to alkyl hydroperoxide +is_a: GO:0072735 ! response to tert-butyl hydroperoxide + +[Term] +id: GO:0072737 +name: response to diamide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [GOC:mah] +synonym: "response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0072738 +name: cellular response to diamide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) stimulus." [GOC:mah] +synonym: "cellular response to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] +is_a: GO:0072737 ! response to diamide +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0072739 +name: response to anisomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [GOC:mah] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:0072740 +name: cellular response to anisomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus." [GOC:mah] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0072739 ! response to anisomycin + +[Term] +id: GO:0072741 +name: protein localization to cell division site +namespace: biological_process +def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689] +synonym: "protein localisation to cell division site" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0072742 +name: SAGA complex localization to transcription regulatory region +namespace: biological_process +def: "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene." [GOC:mah] +synonym: "SAGA complex localization to promoter" EXACT [GOC:mah] +synonym: "SAGA complex recruitment" EXACT [GOC:mah] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0072743 +name: cellular response to erythromycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901323 ! response to erythromycin +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072744 +name: cellular response to trichodermin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:mah] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901324 ! response to trichodermin + +[Term] +id: GO:0072745 +name: cellular response to antimycin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901325 ! response to antimycin A +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072746 +name: cellular response to tetracycline +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:mah] +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901326 ! response to tetracycline +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0072747 +name: cellular response to chloramphenicol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:mah] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901322 ! response to chloramphenicol +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072748 +name: cellular response to tacrolimus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus (FK506) stimulus." [GOC:mah] +synonym: "cellular response to FK506" EXACT [CHEBI:61057] +synonym: "cellular response to tacrolimus hydrate" EXACT [CHEBI:61057] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1901327 ! response to tacrolimus + +[Term] +id: GO:0072749 +name: cellular response to cytochalasin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901328 ! response to cytochalasin B +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072750 +name: cellular response to leptomycin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:mah] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901344 ! response to leptomycin B + +[Term] +id: GO:0072751 +name: cellular response to L-thialysine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:mah] +synonym: "cellular response to thialysine" BROAD [GOC:mah] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1901345 ! response to L-thialysine + +[Term] +id: GO:0072752 +name: cellular response to rapamycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901355 ! response to rapamycin +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0072753 +name: cellular response to glutathione +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:mah] +is_a: GO:1901370 ! response to glutathione +is_a: GO:1901653 ! cellular response to peptide + +[Term] +id: GO:0072754 +name: cellular response to purvalanol A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:mah] +is_a: GO:0071415 ! cellular response to purine-containing compound +is_a: GO:1901560 ! response to purvalanol A + +[Term] +id: GO:0072755 +name: cellular response to benomyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901561 ! response to benomyl +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072756 +name: cellular response to paraquat +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:1901562 ! response to paraquat + +[Term] +id: GO:0072757 +name: cellular response to camptothecin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah] +synonym: "cellular response to CPT" EXACT [GOC:mah] +is_a: GO:0071312 ! cellular response to alkaloid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901563 ! response to camptothecin + +[Term] +id: GO:0072758 +name: response to topoisomerase inhibitor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0072759 +name: cellular response to topoisomerase inhibitor +namespace: biological_process +def: "Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus." [GOC:mah] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:0072758 ! response to topoisomerase inhibitor + +[Term] +id: GO:0072760 +name: cellular response to GW 7647 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:mah] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:1901593 ! response to GW 7647 +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072761 +name: cellular response to capsazepine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901594 ! response to capsazepine +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072762 +name: cellular response to carbendazim +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901597 ! response to carbendazim +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072763 +name: cellular response to hesperadin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:mah] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071418 ! cellular response to amine stimulus +is_a: GO:1901595 ! response to hesperadin +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072764 +name: cellular response to reversine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:mah] +is_a: GO:0071415 ! cellular response to purine-containing compound +is_a: GO:1901596 ! response to reversine +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0072765 +name: centromere localization +namespace: biological_process +def: "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location." [GOC:mah] +synonym: "establishment and maintenance of kinetochore localization" EXACT [GOC:mah] +synonym: "kinetochore localisation" EXACT [GOC:mah] +synonym: "kinetochore localization" EXACT [] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0072766 +name: centromere clustering at the mitotic interphase nuclear envelope +namespace: biological_process +def: "The process in which chromatin, or kinetochores are anchored to the nuclear envelope. This process involves the microtubule cytoskeleton, and nuclear tethering factors and is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei." [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349] +synonym: "centromere clustering at the mitotic nuclear envelope" RELATED [] +synonym: "centromere clustering at the nuclear periphery" BROAD [] +synonym: "centromere-SPB clustering" BROAD [GOC:vw, PMID:18158900] +synonym: "kinetochore clustering at SPB" BROAD [GOC:mah] +synonym: "kinetochore clustering at spindle pole body" BROAD [] +synonym: "kinetochore clustering at the old mitotic spindle pole body" EXACT [] +synonym: "kinetochore localization at spindle pole body" BROAD [GOC:pr] +synonym: "rabl configuration" RELATED [PMID:17881496] +is_a: GO:0097240 ! chromosome attachment to the nuclear envelope +is_a: GO:0098653 ! centromere clustering +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0075000 +name: response to host osmotic environment +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response of symbiont to host osmotic environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075001 +name: adhesion of symbiont infection structure to host +namespace: biological_process +def: "The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. +synonym: "adhesion of symbiont infection structure to host during symbiotic interaction" EXACT [] +synonym: "attachment of symbiont infection structure to host" EXACT [] +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0075002 +name: adhesion of symbiont germination tube to host +namespace: biological_process +def: "The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont germination tube to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075003 +name: adhesion of symbiont appressorium to host +namespace: biological_process +def: "The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont appressorium to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host +relationship: part_of GO:0075016 ! appressorium formation + +[Term] +id: GO:0075004 +name: adhesion of symbiont spore to host +namespace: biological_process +def: "The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont spore to host during symbiotic interaction" EXACT [] +is_a: GO:0044406 ! adhesion of symbiont to host + +[Term] +id: GO:0075009 +name: germ tube formation +namespace: biological_process +def: "Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "germ tube formation on or near host" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0009847 ! spore germination + +[Term] +id: GO:0075010 +name: regulation of germ tube formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0075009 ! germ tube formation + +[Term] +id: GO:0075011 +name: positive regulation of germ tube formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "positive regulation of germ tube formation on or near host" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075010 ! regulation of germ tube formation +relationship: positively_regulates GO:0075009 ! germ tube formation + +[Term] +id: GO:0075012 +name: negative regulation of germ tube formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of germ tube formation on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "negative regulation of germ tube formation on or near host" EXACT [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075010 ! regulation of germ tube formation +relationship: negatively_regulates GO:0075009 ! germ tube formation + +[Term] +id: GO:0075013 +name: obsolete growth or development of symbiont on or near host phyllosphere +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "growth or development of symbiont on or near host phyllosphere" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075014 +name: obsolete growth or development of symbiont on or near host rhizosphere +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "growth or development of symbiont on or near host rhizosphere" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075015 +name: formation of infection structure +namespace: biological_process +def: "The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. +synonym: "formation by symbiont of infection structure on or near host" RELATED [] +synonym: "formation of host infection structure" EXACT [] +synonym: "formation of host penetration structure" RELATED [] +synonym: "formation of infection structure on or near host" RELATED [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0044409 ! entry into host + +[Term] +id: GO:0075016 +name: appressorium formation +namespace: biological_process +def: "The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface." [GOC:pamgo_curators] +synonym: "appressorium formation for entry into host, on or near host" EXACT [] +synonym: "appressorium formation on or near host" RELATED [] +synonym: "formation of an appressorium by symbiont on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075017 +name: regulation of appressorium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators] +synonym: "regulation of appressorium formation on or near host" RELATED [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0075016 ! appressorium formation + +[Term] +id: GO:0075018 +name: positive regulation of appressorium formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of appressorium formation on or near host" RELATED [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075017 ! regulation of appressorium formation +relationship: positively_regulates GO:0075016 ! appressorium formation + +[Term] +id: GO:0075019 +name: negative regulation of appressorium formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "negative regulation of appressorium formation on or near host" RELATED [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075017 ! regulation of appressorium formation +relationship: negatively_regulates GO:0075016 ! appressorium formation + +[Term] +id: GO:0075020 +name: obsolete calcium or calmodulin-mediated activation of appressorium formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont calcium or calmodulin-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "Ca++ or calmodulin-mediated activation of appressorium formation" EXACT [] +synonym: "Ca2+ or calmodulin-mediated activation of appressorium formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075021 +name: obsolete cAMP-mediated activation of appressorium formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cAMP mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "cyclic AMP mediated activation of appressorium formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075022 +name: obsolete ethylene-mediated activation of appressorium formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont ethylene-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0075023 +name: obsolete MAPK-mediated regulation of appressorium formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont MAP kinase-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "mitogen-activated protein kinase-mediated activation of appressorium formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075024 +name: obsolete phospholipase C-mediated activation of appressorium formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont phospholipase C-mediated signal transduction during appressorium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0075025 +name: initiation of appressorium formation +namespace: biological_process +def: "The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "appressorium initiation on or near host" EXACT [] +synonym: "initiation of appressorium by symbiont on or near host" EXACT [] +synonym: "initiation of appressorium on or near host" RELATED [] +synonym: "initiation of symbiont appressorium on or near host" EXACT [] +is_a: GO:0044111 ! formation of structure involved in a symbiotic process +relationship: part_of GO:0075016 ! appressorium formation + +[Term] +id: GO:0075026 +name: regulation of appressorium initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium initiation." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of appressorium initiation on or near host" RELATED [] +synonym: "regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0075017 ! regulation of appressorium formation +relationship: regulates GO:0075025 ! initiation of appressorium formation + +[Term] +id: GO:0075027 +name: positive regulation of appressorium initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation." [GOC:pamgo_curators] +synonym: "positive regulation of appressorium initiation on or near host" RELATED [] +synonym: "positive regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +is_a: GO:0075018 ! positive regulation of appressorium formation +is_a: GO:0075026 ! regulation of appressorium initiation +relationship: positively_regulates GO:0075025 ! initiation of appressorium formation + +[Term] +id: GO:0075028 +name: negative regulation of appressorium initiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation." [GOC:pamgo_curators] +synonym: "negative regulation of appressorium initiation on or near host" RELATED [] +synonym: "negative regulation of initiation of appressorium on or near host" EXACT [] +is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process +is_a: GO:0075019 ! negative regulation of appressorium formation +is_a: GO:0075026 ! regulation of appressorium initiation +relationship: negatively_regulates GO:0075025 ! initiation of appressorium formation + +[Term] +id: GO:0075029 +name: formation of appressorium germ tube hook structure +namespace: biological_process +def: "The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation." [GOC:pamgo_curators] +synonym: "formation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "formation of symbiont germ tube hook structure for appressorium development" EXACT [] +synonym: "formation of symbiont germ tube hook structure on or near host" RELATED [] +synonym: "symbiont germ tube hook structure formation on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure +relationship: part_of GO:0075025 ! initiation of appressorium formation + +[Term] +id: GO:0075030 +name: modulation of formation of symbiont germ tube hook structure for appressorium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators] +synonym: "modulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "modulation of symbiont germ tube hook structure formation on or near host" RELATED [] +synonym: "regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +is_a: GO:0075026 ! regulation of appressorium initiation +relationship: regulates GO:0075029 ! formation of appressorium germ tube hook structure + +[Term] +id: GO:0075031 +name: positive regulation of formation of symbiont germ tube hook structure for appressorium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators] +synonym: "positive regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +synonym: "positive regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "positive regulation of symbiont germ tube hook structure formation on or near host" RELATED [] +is_a: GO:0075027 ! positive regulation of appressorium initiation +is_a: GO:0075030 ! modulation of formation of symbiont germ tube hook structure for appressorium development +relationship: positively_regulates GO:0075029 ! formation of appressorium germ tube hook structure + +[Term] +id: GO:0075032 +name: negative regulation of formation of symbiont germ tube hook structure for appressorium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation." [GOC:pamgo_curators] +synonym: "negative regulation of formation of symbiont germ tube hook structure on or near host" EXACT [] +synonym: "negative regulation of germ tube tip of symbiont on or near the exterior of host" EXACT [] +synonym: "negative regulation of symbiont germ tube hook structure formation on or near host" RELATED [] +is_a: GO:0075028 ! negative regulation of appressorium initiation +is_a: GO:0075030 ! modulation of formation of symbiont germ tube hook structure for appressorium development +relationship: negatively_regulates GO:0075029 ! formation of appressorium germ tube hook structure + +[Term] +id: GO:0075033 +name: obsolete appressorium septum formation +namespace: biological_process +def: "OBSOLETE. The process in which a symbiont partition is formed to separate the appressorium from the germination tube, occurring during appressorium formation." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that this process exists. +synonym: "septum formation during appressorium formation on or near host" RELATED [GOC:tb] +synonym: "septum formation involved in appressorium formation" EXACT [] +synonym: "septum formation involved in appressorium formation on or near host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075034 +name: obsolete nuclear division involved in appressorium formation +namespace: biological_process +def: "OBSOLETE. The process in which nuclear division occurs within a symbiont spore that contributes to appressorium formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:dph, GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that this process exists. +synonym: "nuclear division during appressorium formation on or near host" RELATED [GOC:dph] +synonym: "nuclear division involved in appressorium formation on or near host" RELATED [] +is_obsolete: true + +[Term] +id: GO:0075035 +name: appressorium maturation +namespace: biological_process +def: "The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "appressorium maturation on or near host" EXACT [] +synonym: "maturation of appressorium on or near host" RELATED [] +synonym: "maturation of symbiont appressorium on or near host" EXACT [] +is_a: GO:0044111 ! formation of structure involved in a symbiotic process +relationship: part_of GO:0075016 ! appressorium formation + +[Term] +id: GO:0075036 +name: regulation of appressorium maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont appressorium maturation." [GOC:pamgo_curators] +synonym: "regulation of appressorium maturation on or near host" RELATED [] +synonym: "regulation of maturation of appressorium on or near host" EXACT [] +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +relationship: regulates GO:0075035 ! appressorium maturation + +[Term] +id: GO:0075037 +name: positive regulation of appressorium maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation." [GOC:pamgo_curators] +synonym: "positive regulation maturation of appressorium on or near host" EXACT [] +synonym: "positive regulation of appressorium maturation on or near host" RELATED [] +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +is_a: GO:0075018 ! positive regulation of appressorium formation +is_a: GO:0075036 ! regulation of appressorium maturation +relationship: positively_regulates GO:0075035 ! appressorium maturation + +[Term] +id: GO:0075038 +name: negative regulation of appressorium maturation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation." [GOC:pamgo_curators] +synonym: "negative regulation of appressorium maturation on or near host" RELATED [] +synonym: "negative regulation of maturation of appressorium on or near host" EXACT [] +is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process +is_a: GO:0075019 ! negative regulation of appressorium formation +is_a: GO:0075036 ! regulation of appressorium maturation +relationship: negatively_regulates GO:0075035 ! appressorium maturation + +[Term] +id: GO:0075039 +name: establishment of turgor in appressorium +namespace: biological_process +def: "The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "establishment of turgor in symbiont appressorium on or near host" EXACT [] +synonym: "formation of turgor in appressorium" EXACT [] +synonym: "generation of turgor in appressorium" EXACT [] +is_a: GO:0044111 ! formation of structure involved in a symbiotic process +relationship: part_of GO:0075035 ! appressorium maturation + +[Term] +id: GO:0075040 +name: regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process modulates the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators] +synonym: "regulation of turgor formation in appressorium" RELATED [] +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +relationship: regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075041 +name: positive regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators] +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +is_a: GO:0075018 ! positive regulation of appressorium formation +is_a: GO:0075040 ! regulation of establishment of turgor in appressorium +relationship: positively_regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075042 +name: negative regulation of establishment of turgor in appressorium +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium." [GOC:pamgo_curators] +is_a: GO:0075038 ! negative regulation of appressorium maturation +is_a: GO:0075040 ! regulation of establishment of turgor in appressorium +relationship: negatively_regulates GO:0075039 ! establishment of turgor in appressorium + +[Term] +id: GO:0075043 +name: melanization of appressorium wall +namespace: biological_process +def: "The process in which melanin is produced in the appressorium of the symbiont. Melanization of the appressorium increases turgor pressure in the appressorium." [GOC:pamgo_curators, PMID:28165657, Wikipedia:Appressorium] +synonym: "maintenance of turgor in appressorium by melanization" RELATED [] +synonym: "melanization of appressorium to maintain turgor pressure" EXACT [] +is_a: GO:0043476 ! pigment accumulation +relationship: part_of GO:0075035 ! appressorium maturation + +[Term] +id: GO:0075044 +name: positive regulation by symbiont of host autophagy +namespace: biological_process +def: "Any process in which a symbiont organism increases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "autophagy of host cells during interaction with symbiont" RELATED [GOC:dph] +synonym: "autophagy of host cells involved in interaction with symbiont" RELATED [] +synonym: "positive regulation by symbiont of host autophagotic process" RELATED [] +is_a: GO:0075071 ! modulation by symbiont of host autophagy +relationship: positively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0075045 +name: regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +relationship: regulates GO:0052094 ! formation of haustorium for nutrient acquisition + +[Term] +id: GO:0075046 +name: positive regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host +relationship: positively_regulates GO:0052094 ! formation of haustorium for nutrient acquisition + +[Term] +id: GO:0075047 +name: negative regulation of formation by symbiont of haustorium for nutrient acquisition from host +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process +is_a: GO:0075045 ! regulation of formation by symbiont of haustorium for nutrient acquisition from host +relationship: negatively_regulates GO:0052094 ! formation of haustorium for nutrient acquisition + +[Term] +id: GO:0075048 +name: obsolete cell wall strengthening in symbiont involved in entry into host +namespace: biological_process +def: "OBSOLETE. A process in which the cell wall of the symbiont is strengthened or thickened during penetration into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "cell wall strengthening in symbiont during entry into host" RELATED [GOC:tb] +synonym: "cell wall thickening in symbiont during entry into host" RELATED [] +synonym: "symbiont cell wall strengthening during entry into host" RELATED [] +is_obsolete: true + +[Term] +id: GO:0075049 +name: obsolete modulation of symbiont cell wall strengthening involved in entry into host +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for the obsoletion is that there is no evidence that those processes exist. +synonym: "modulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0075050 +name: obsolete positive regulation of symbiont cell wall strengthening involved in entry into host +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for the obsoletion is that there is no evidence that those processes exist. +synonym: "positive regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0075051 +name: obsolete negative regulation of symbiont cell wall strengthening involved in entry into host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont cell wall strengthening during entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for the obsoletion is that there is no evidence that those processes exist. +synonym: "negative regulation of symbiont cell wall strengthening during entry into host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0075053 +name: penetration peg formation +namespace: biological_process +alt_id: GO:0075057 +def: "The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation of symbiont penetration peg for entry into host" RELATED [] +synonym: "initiation of symbiont penetration peg" NARROW [] +synonym: "symbiont penetration peg formation for entry into host" RELATED [] +synonym: "symbiont penetration peg initiation" NARROW [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075054 +name: modulation of penetration peg formation +namespace: biological_process +alt_id: GO:0075058 +def: "Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "modulation of symbiont penetration peg formation for entry into host" NARROW [] +synonym: "modulation of symbiont penetration peg initiation" NARROW [] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: regulates GO:0075053 ! penetration peg formation + +[Term] +id: GO:0075055 +name: positive regulation of penetration peg formation +namespace: biological_process +alt_id: GO:0075059 +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of symbiont penetration peg formation for entry into host" NARROW [] +synonym: "positive regulation of symbiont penetration peg initiation" NARROW [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075054 ! modulation of penetration peg formation +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +relationship: positively_regulates GO:0075053 ! penetration peg formation + +[Term] +id: GO:0075056 +name: obsolete negative regulation of penetration peg formation +namespace: biological_process +alt_id: GO:0075060 +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont penetration peg formation for entry into host" NARROW [] +synonym: "negative regulation of symbiont penetration peg initiation" NARROW [] +is_obsolete: true + +[Term] +id: GO:0075062 +name: obsolete regulation of invasive hypha growth +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont invasive hypha formation in host" EXACT [] +synonym: "regulation of symbiont invasive hypha formation within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075063 +name: obsolete positive regulation of invasive hypha growth +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont invasive hypha formation in host" EXACT [] +synonym: "positive regulation of symbiont invasive hypha formation within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075064 +name: obsolete negative regulation invasive hypha growth +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont invasive hypha formation within host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont invasive hypha formation in host" EXACT [] +synonym: "negative regulation of symbiont invasive hypha formation within host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075065 +name: obsolete growth or development of symbiont in host cell +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development of symbiont in host cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075066 +name: obsolete growth or development of symbiont in host organelle +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development of symbiont in host organelle" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075067 +name: obsolete growth or development of symbiont in host intercellular space +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "growth or development of symbiont in host intercellular space" EXACT [] +is_obsolete: true +consider: GO:0044114 +consider: GO:0051701 + +[Term] +id: GO:0075068 +name: obsolete growth or development of symbiont in host vascular tissue +namespace: biological_process +def: "OBSOLETE. The increase in size or mass of symbiont, or the progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). It has been replaced with the terms 'development of symbiont in host vascular tissue ; GO:0044122' and 'growth of symbiont in host vascular tissue ; GO:0044123'. +synonym: "growth or development of symbiont in host vascular tissue" EXACT [] +is_obsolete: true +consider: GO:0044114 +consider: GO:0051701 + +[Term] +id: GO:0075069 +name: adhesion of symbiont infection cushion to host +namespace: biological_process +def: "The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont infection cushion to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075070 +name: adhesion of symbiont hyphopodium to host +namespace: biological_process +def: "The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont hyphopodium to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075071 +name: modulation by symbiont of host autophagy +namespace: biological_process +def: "Any process in which a symbiont organism modulates the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "autophagy during symbiotic interaction" RELATED [GOC:dph] +synonym: "autophagy involved in symbiotic interaction" RELATED [] +synonym: "modulation by symbiont of host autophagic process" RELATED [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0006914 ! autophagy + +[Term] +id: GO:0075072 +name: obsolete autophagy of symbiont cells involved in interaction with host +namespace: biological_process +def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm during interaction with its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. +synonym: "autophagy of symbiont cells during interaction with host" RELATED [GOC:dph] +is_obsolete: true + +[Term] +id: GO:0075073 +name: obsolete autophagy of symbiont cells on or near host surface +namespace: biological_process +def: "OBSOLETE. The process in which symbiont cells digest parts of their own cytoplasm, occurring when the symbiont is on or near its host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. +is_obsolete: true + +[Term] +id: GO:0075074 +name: obsolete spore autophagy involved in appressorium formation on or near host +namespace: biological_process +def: "OBSOLETE. The process in which a symbiont spore digests parts of its own cytoplasm, occurring when the appressorium forms on or near the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. +synonym: "autophagy of spores during appressorium formation on or near host" EXACT [] +synonym: "spore autophagy during appressorium formation on or near host" RELATED [GOC:tb] +is_obsolete: true + +[Term] +id: GO:0075075 +name: obsolete modulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0075076 +name: obsolete positive regulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0075077 +name: obsolete negative regulation by host of symbiont adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0075078 +name: obsolete modulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075079 +name: obsolete positive regulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075080 +name: obsolete negative regulation by host of symbiont receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075081 +name: obsolete modulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075082 +name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075083 +name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075084 +name: obsolete modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "modulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075085 +name: obsolete positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "activation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "positive regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +synonym: "promotion by host of symbiont transmembrane receptor protein activity involved in cAMP-mediated signal transduction" EXACT [] +synonym: "stimulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "upregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075086 +name: obsolete negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated cAMP signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "downregulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "inhibition by host of symbiont transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "negative regulation by host of symbiont transmembrane receptor-mediated cAMP signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075087 +name: obsolete modulation by host of symbiont G protein-coupled receptor signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "modulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075088 +name: obsolete positive regulation by host of symbiont G protein-coupled receptor signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "positive regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075089 +name: obsolete negative regulation by host of symbiont G protein-coupled receptor signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "negative regulation by host of symbiont G-protein coupled receptor protein signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075090 +name: obsolete modulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075091 +name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075092 +name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein alpha subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075093 +name: obsolete modulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075094 +name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075095 +name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein beta subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075096 +name: obsolete modulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075097 +name: obsolete positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075098 +name: obsolete negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont signal transduction mediated by G-protein gamma subunit. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075099 +name: obsolete modulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075100 +name: obsolete positive regulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075101 +name: obsolete negative regulation by host of symbiont protein kinase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075102 +name: obsolete negative regulation by host of symbiont MAP kinase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of the symbiont MAP kinase-mediated signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075103 +name: obsolete modulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "modulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075104 +name: obsolete positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "positive regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075105 +name: obsolete negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "negative regulation by host of symbiont Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075106 +name: obsolete modulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "Modulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "Modulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "Modulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "Modulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +synonym: "Modulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] +synonym: "Modulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] +synonym: "Modulation by symbiont of host cAMP generating peptide activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0075107 +name: obsolete positive regulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host adenylate cyclase activity, which involves catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "positive regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "positive regulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "positive regulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "positive regulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "positive regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075108 +name: obsolete negative regulation by symbiont of host adenylate cyclase activity +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host adenylate cyclase activity, which catalyze the reaction: ATP = 3',5'-cyclic AMP + diphosphate. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "Negative regulation by symbiont of host 3',5'-cyclic AMP synthetase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenyl cyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenylyl cyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host adenylylcyclase activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing ; 3',5'-cyclic-AMP-forming) activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP diphosphate-lyase (cyclizing) activity" EXACT [] +synonym: "Negative regulation by symbiont of host ATP pyrophosphate-lyase activity" EXACT [] +synonym: "Negative regulation by symbiont of host cAMP generating peptide activity" RELATED [] +is_obsolete: true + +[Term] +id: GO:0075109 +name: modulation by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075110 +name: induction by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". +synonym: "positive regulation by symbiont of host receptor-mediated signal transduction" EXACT [] +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075111 +name: suppression by symbiont of host receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080". +synonym: "negative regulation by symbiont of host receptor-mediated signal transduction" EXACT [] +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075112 +name: modulation by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081". +is_a: GO:0075109 ! modulation by symbiont of host receptor-mediated signal transduction + +[Term] +id: GO:0075113 +name: induction by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". +synonym: "positive regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT [] +is_a: GO:0075110 ! induction by symbiont of host receptor-mediated signal transduction +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075114 +name: suppression by symbiont of host transmembrane receptor-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083". +synonym: "negative regulation by symbiont of host transmembrane receptor-mediated signal transduction" EXACT [] +is_a: GO:0075111 ! suppression by symbiont of host receptor-mediated signal transduction +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075115 +name: obsolete modulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont modulates the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that this process exists. +synonym: "modulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075116 +name: obsolete induction by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that this process exists. +synonym: "activation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "positive regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +synonym: "promotion by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "stimulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "upregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075117 +name: obsolete suppression by symbiont of host transmembrane receptor-mediated cAMP signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of host transmembrane receptor-mediated cAMP signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that this process exists. +synonym: "downregulation by symbiont of host transmembrane receptor-mediated cAMP signal transduction" EXACT [] +synonym: "inhibition by symbiont of host transmembrane receptor-mediated cAMP signal transduction" NARROW [] +synonym: "negative regulation by symbiont of host transmembrane receptor-mediated cAMP signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075118 +name: modulation by symbiont of host G protein-coupled receptor signal transduction +namespace: biological_process +alt_id: GO:0075121 +alt_id: GO:0075124 +alt_id: GO:0075127 +def: "Any process in which the symbiont modulates the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075087". +synonym: "modulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] +synonym: "modulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] +synonym: "modulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] +synonym: "modulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:0075112 ! modulation by symbiont of host transmembrane receptor-mediated signal transduction + +[Term] +id: GO:0075119 +name: induction by symbiont of host G protein-coupled receptor signal transduction +namespace: biological_process +alt_id: GO:0075122 +alt_id: GO:0075125 +alt_id: GO:0075128 +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G protein-coupled receptor signal transduction ; GO:0075088". +synonym: "positive regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [] +synonym: "positive regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] +synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] +synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] +synonym: "positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0075113 ! induction by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075118 ! modulation by symbiont of host G protein-coupled receptor signal transduction + +[Term] +id: GO:0075120 +name: suppression by symbiont of host G protein-coupled receptor signal transduction +namespace: biological_process +alt_id: GO:0075123 +alt_id: GO:0075126 +alt_id: GO:0075129 +def: "Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075089". +synonym: "negative regulation by symbiont of host G protein-coupled receptor signal transduction" EXACT [] +synonym: "negative regulation by symbiont of host G-protein coupled receptor protein signal transduction" EXACT [] +synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit" NARROW [] +synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit" NARROW [] +synonym: "negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit" NARROW [] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0075114 ! suppression by symbiont of host transmembrane receptor-mediated signal transduction +is_a: GO:0075118 ! modulation by symbiont of host G protein-coupled receptor signal transduction + +[Term] +id: GO:0075130 +name: modulation by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075131 +name: induction by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100". +synonym: "positive regulation by symbiont of host protein kinase-mediated signal transduction" EXACT [] +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0075132 +name: suppression by symbiont of host protein kinase-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101". +synonym: "negative regulation by symbiont of host protein kinase-mediated signal transduction" EXACT [] +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway +is_a: GO:0075130 ! modulation by symbiont of host protein kinase-mediated signal transduction + +[Term] +id: GO:0075133 +name: modulation by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". +synonym: "modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075134 +name: induction by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104". +synonym: "positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +synonym: "positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075135 +name: suppression by symbiont of host calcium or calmodulin-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". +synonym: "negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction" EXACT [] +synonym: "negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction" EXACT [] +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway +is_a: GO:0075133 ! modulation by symbiont of host calcium or calmodulin-mediated signal transduction + +[Term] +id: GO:0075136 +name: response to host +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host" RELATED [] +is_a: GO:0051701 ! biological process involved in interaction with host +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0075137 +name: response to host redox environment +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host redox environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075138 +name: response to host oxygen tension environment +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host oxygen tension environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075139 +name: response to host iron concentration +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. +synonym: "response of symbiont to host iron concentration" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075141 +name: obsolete symbiont tolerance to host environment +namespace: biological_process +alt_id: GO:0075142 +alt_id: GO:0075143 +alt_id: GO:0075144 +alt_id: GO:0075146 +alt_id: GO:0075238 +def: "OBSOLETE. Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it is redundant with other terms. +synonym: "maintenance of symbiont tolerance to host environment" RELATED [] +synonym: "maintenance of symbiont tolerance to host iron concentration" NARROW [] +synonym: "maintenance of symbiont tolerance to host osmotic environment" NARROW [] +synonym: "maintenance of symbiont tolerance to host oxygen tension environment" NARROW [] +synonym: "maintenance of symbiont tolerance to host pH environment" NARROW [] +synonym: "maintenance of symbiont tolerance to host redox environment" NARROW [] +is_obsolete: true +consider: GO:0052200 + +[Term] +id: GO:0075147 +name: obsolete regulation of signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075148 +name: obsolete positive regulation of signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075149 +name: obsolete negative regulation of signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075150 +name: obsolete regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075151 +name: obsolete positive regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075152 +name: obsolete negative regulation of receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont receptor-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075153 +name: obsolete regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075154 +name: obsolete positive regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075155 +name: obsolete negative regulation of transmembrane receptor-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont transmembrane receptor-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075156 +name: obsolete regulation of G protein-coupled receptor signaling pathway in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] +synonym: "regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] +synonym: "regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075157 +name: obsolete positive regulation of G protein-coupled receptor signaling pathway in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] +synonym: "positive regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] +synonym: "positive regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075158 +name: obsolete negative regulation of G protein-coupled receptor signaling pathway in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G protein-coupled receptor-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of G-protein coupled receptor protein signaling pathway in response to host" EXACT [] +synonym: "negative regulation of G-protein coupled receptor protein signalling pathway in response to host" EXACT [GOC:mah] +synonym: "negative regulation of symbiont G-protein coupled receptor protein-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075159 +name: obsolete regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075160 +name: obsolete positive regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075161 +name: obsolete negative regulation of G-protein alpha subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein alpha subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont G-protein alpha subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075162 +name: obsolete regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075163 +name: obsolete positive regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075164 +name: obsolete negative regulation of G-protein beta subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein beta subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont G-protein beta subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075165 +name: obsolete regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075166 +name: obsolete positive regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075167 +name: obsolete negative regulation of G-protein gamma subunit-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont G-protein gamma subunit-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont G-protein gamma subunit-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075168 +name: obsolete regulation of protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075169 +name: obsolete positive regulation of symbiont protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075170 +name: obsolete negative regulation of protein kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont protein kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont protein kinase-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075171 +name: obsolete regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075172 +name: obsolete positive regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075173 +name: obsolete negative regulation of MAP kinase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont MAP kinase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont MAP kinase-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075174 +name: obsolete regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075175 +name: obsolete positive regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "positive regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "positive regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075176 +name: obsolete negative regulation of cAMP-mediated signaling in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its cAMP-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of cAMP-mediated signal transduction in response to host" EXACT [] +synonym: "negative regulation of cAMP-mediated signalling in response to host" EXACT [] +synonym: "negative regulation of symbiont cAMP-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075177 +name: obsolete regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "modulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "modulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075178 +name: obsolete positive regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "positive regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075179 +name: obsolete negative regulation of calcium or calmodulin-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont calcium or calmodulin-mediated signal transduction as a result of detecting host molecules in, on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont Ca++ or calmodulin-mediated signal transduction in response to host" EXACT [] +synonym: "negative regulation of symbiont calcium or calmodulin-mediated signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075180 +name: obsolete regulation of transcription in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006355 + +[Term] +id: GO:0075181 +name: obsolete positive regulation of symbiont transcription in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006355 + +[Term] +id: GO:0075182 +name: obsolete negative regulation of symbiont transcription in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0045892 + +[Term] +id: GO:0075183 +name: infection cushion formation +namespace: biological_process +def: "The process in which an organized mass of hyphae is formed and numerous infective hyphae develop from the hyphae mass." [GOC:pamgo_curators] +synonym: "infection cushion formation on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075184 +name: regulation of infection cushion formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont infection cushion formation." [GOC:pamgo_curators] +synonym: "regulation of infection cushion formation on or near host" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0075183 ! infection cushion formation + +[Term] +id: GO:0075185 +name: positive regulation of infection cushion formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "positive regulation of infection cushion formation on or near host" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075184 ! regulation of infection cushion formation +relationship: positively_regulates GO:0075183 ! infection cushion formation + +[Term] +id: GO:0075186 +name: negative regulation of infection cushion formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont infection cushion formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "negative regulation of infection cushion formation on or near host" EXACT [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075184 ! regulation of infection cushion formation +relationship: negatively_regulates GO:0075183 ! infection cushion formation + +[Term] +id: GO:0075187 +name: hyphopodium formation +namespace: biological_process +def: "The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "hyphopodium formation on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075188 +name: regulation of hyphopodium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of hyphopodium formation on or near host" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0075187 ! hyphopodium formation + +[Term] +id: GO:0075189 +name: positive regulation of hyphopodium formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "positive regulation of hyphopodium formation on or near host" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075188 ! regulation of hyphopodium formation +relationship: positively_regulates GO:0075187 ! hyphopodium formation + +[Term] +id: GO:0075190 +name: negative regulation of hyphopodium formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "negative regulation of hyphopodium formation on or near host" EXACT [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075188 ! regulation of hyphopodium formation +relationship: negatively_regulates GO:0075187 ! hyphopodium formation + +[Term] +id: GO:0075191 +name: obsolete autophagy of host cells on or near symbiont surface +namespace: biological_process +def: "OBSOLETE. The process in which the host cells digest parts of their own cytoplasm, occurring when the host is on or near its symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that this term did not represent any specific host/symbiont process. +is_obsolete: true + +[Term] +id: GO:0075192 +name: haustorium mother cell formation +namespace: biological_process +def: "The process in which a symbiont cell is formed, separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "haustorium mother cell formation on or near host" EXACT [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075193 +name: regulation of haustorium mother cell formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "regulation of haustorium mother cell formation on or near host" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0075192 ! haustorium mother cell formation + +[Term] +id: GO:0075194 +name: positive regulation of haustorium mother cell formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of haustorium mother cell formation on or near host" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075193 ! regulation of haustorium mother cell formation +relationship: positively_regulates GO:0075192 ! haustorium mother cell formation + +[Term] +id: GO:0075195 +name: negative regulation of haustorium mother cell formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium mother cell formation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "negative regulation of haustorium mother cell formation on or near host" EXACT [] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0075193 ! regulation of haustorium mother cell formation +relationship: negatively_regulates GO:0075192 ! haustorium mother cell formation + +[Term] +id: GO:0075196 +name: adhesion of symbiont haustorium mother cell to host +namespace: biological_process +def: "The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "adhesion of symbiont haustorium mother cell to host during symbiotic interaction" EXACT [] +is_a: GO:0075001 ! adhesion of symbiont infection structure to host + +[Term] +id: GO:0075197 +name: haustorium neck formation +namespace: biological_process +def: "The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, Wikipedia:Haustorium] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation of symbiont haustorium neck for entry into host" RELATED [] +synonym: "symbiont haustorium neck formation for entry into host" RELATED [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075198 +name: modulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: regulates GO:0075197 ! haustorium neck formation + +[Term] +id: GO:0075199 +name: positive regulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075198 ! modulation of symbiont haustorium neck formation for entry into host +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +relationship: positively_regulates GO:0075197 ! haustorium neck formation + +[Term] +id: GO:0075200 +name: obsolete negative regulation of symbiont haustorium neck formation for entry into host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075201 +name: penetration hypha formation +namespace: biological_process +def: "The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators, PMID:26441323] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation of symbiont penetration hypha for entry into host" RELATED [] +synonym: "symbiont penetration hypha formation for entry into host" RELATED [] +is_a: GO:0075015 ! formation of infection structure + +[Term] +id: GO:0075202 +name: regulation of penetration hypha formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "modulation of symbiont penetration hypha formation for entry into host" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: regulates GO:0075201 ! penetration hypha formation + +[Term] +id: GO:0075203 +name: positive regulation of penetration hypha formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "positive regulation of symbiont penetration hypha formation for entry into host" EXACT [] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0075202 ! regulation of penetration hypha formation +is_a: GO:0075294 ! positive regulation by symbiont of entry into host +relationship: positively_regulates GO:0075201 ! penetration hypha formation + +[Term] +id: GO:0075204 +name: obsolete negative regulation of symbiont penetration hypha formation for entry into host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075205 +name: obsolete modulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The cAMP-mediated signal transduction is defined as a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "modulation by host of symbiont cAMP-mediated signaling" RELATED [] +synonym: "modulation by host of symbiont cAMP-mediated signalling" EXACT [] +synonym: "regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075206 +name: obsolete positive regulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "positive regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075207 +name: obsolete negative regulation by host of symbiont cAMP-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +synonym: "negative regulation by host of symbiont cAMP-mediated signaling" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075208 +name: modulation by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". +synonym: "modulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0043949 ! regulation of cAMP-mediated signaling +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0075209 +name: induction by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". +synonym: "positive regulation by symbiont of host cAMP-mediated signal transduction" EXACT [] +synonym: "positive regulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0052028 ! induction by symbiont of host signal transduction pathway +is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075210 +name: suppression by symbiont of host cAMP-mediated signal transduction +namespace: biological_process +def: "Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207". +synonym: "negative regulation by symbiont of host cAMP-mediated signal transduction" EXACT [] +synonym: "negative regulation by symbiont of host cAMP-mediated signaling" EXACT [] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway +is_a: GO:0075208 ! modulation by symbiont of host cAMP-mediated signal transduction + +[Term] +id: GO:0075211 +name: obsolete regulation of transmembrane receptor-mediated cAMP signaling in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +synonym: "regulation of transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +synonym: "regulation of transmembrane receptor-mediated cAMP signalling in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075212 +name: obsolete positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "positive regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" RELATED [] +is_obsolete: true + +[Term] +id: GO:0075213 +name: obsolete negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont transmembrane receptor-mediated cAMP signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "negative regulation of symbiont transmembrane receptor-mediated cAMP signal transduction in response to host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075214 +name: spore encystment +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:kmv, GOC:pamgo_curators] +synonym: "spore encystment on host" RELATED [] +is_a: GO:0022611 ! dormancy process +is_a: GO:0048468 ! cell development + +[Term] +id: GO:0075215 +name: modulation of spore encystment on host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0075214 ! spore encystment + +[Term] +id: GO:0075216 +name: positive regulation of spore encystment on host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0075215 ! modulation of spore encystment on host +relationship: positively_regulates GO:0075214 ! spore encystment + +[Term] +id: GO:0075217 +name: negative regulation of spore encystment on host +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0075215 ! modulation of spore encystment on host +relationship: negatively_regulates GO:0075214 ! spore encystment + +[Term] +id: GO:0075218 +name: zoospore encystment on host +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075214 ! spore encystment + +[Term] +id: GO:0075219 +name: modulation of zoospore encystment on host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075215 ! modulation of spore encystment on host +relationship: regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075220 +name: positive regulation of zoospore encystment on host +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075216 ! positive regulation of spore encystment on host +is_a: GO:0075219 ! modulation of zoospore encystment on host +relationship: positively_regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075221 +name: negative regulation of zoospore encystment on host +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +is_a: GO:0075217 ! negative regulation of spore encystment on host +is_a: GO:0075219 ! modulation of zoospore encystment on host +relationship: negatively_regulates GO:0075218 ! zoospore encystment on host + +[Term] +id: GO:0075222 +name: sporangium germination +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth. A sporangium is a structure producing and containing spores." [GOC:pamgo_curators] +synonym: "direct germination on or near host" NARROW [] +synonym: "germination of symbiont sporangium on or near host" EXACT [] +synonym: "sporangium germination on or near host" EXACT [] +synonym: "symbiont sporangium germination on or near host" EXACT [] +is_a: GO:0043582 ! sporangium development + +[Term] +id: GO:0075223 +name: regulation of sporangium germination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators] +synonym: "modulation of sporangium germination" NARROW [] +synonym: "modulation of sporangium germination on or near host" NARROW [] +is_a: GO:0075310 ! regulation of sporangium development +relationship: regulates GO:0075222 ! sporangium germination + +[Term] +id: GO:0075224 +name: positive regulation of sporangium germination +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators] +synonym: "positive regulation of sporangium germination on or near host" NARROW [] +is_a: GO:0075223 ! regulation of sporangium germination +is_a: GO:0075311 ! positive regulation of sporangium development +relationship: positively_regulates GO:0075222 ! sporangium germination + +[Term] +id: GO:0075225 +name: negative regulation of sporangium germination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium germination." [GOC:pamgo_curators] +synonym: "negative regulation of sporangium germination on or near host" NARROW [] +is_a: GO:0075223 ! regulation of sporangium germination +is_a: GO:0075312 ! negative regulation of sporangium development +relationship: negatively_regulates GO:0075222 ! sporangium germination + +[Term] +id: GO:0075226 +name: encysted zoospore germination +namespace: biological_process +def: "The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "encysted zoospore germination on or near host" EXACT [] +is_a: GO:0009847 ! spore germination + +[Term] +id: GO:0075227 +name: regulation of encysted zoospore germination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an encysted zoospore germination." [GOC:pamgo_curators] +synonym: "modulation of encysted zoospore germination on or near host" EXACT [] +synonym: "regulation of encysted zoospore germination on or near host" NARROW [] +is_a: GO:1904359 ! regulation of spore germination +relationship: regulates GO:0075226 ! encysted zoospore germination + +[Term] +id: GO:0075228 +name: positive regulation of encysted zoospore germination +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of encysted zoospore germination." [GOC:pamgo_curators] +synonym: "positive regulation of encysted zoospore germination on or near host" EXACT [] +is_a: GO:0075227 ! regulation of encysted zoospore germination +is_a: GO:1904361 ! positive regulation of spore germination +relationship: positively_regulates GO:0075226 ! encysted zoospore germination + +[Term] +id: GO:0075229 +name: negative regulation of encysted zoospore germination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of encysted zoospore germination." [GOC:pamgo_curators] +synonym: "negative regulation of encysted zoospore germination on or near host" EXACT [] +is_a: GO:0075227 ! regulation of encysted zoospore germination +is_a: GO:1904360 ! negative regulation of spore germination +relationship: negatively_regulates GO:0075226 ! encysted zoospore germination + +[Term] +id: GO:0075230 +name: obsolete spore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process involved in the directed movement of a motile spore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075231 +name: obsolete modulation of spore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075232 +name: obsolete positive regulation of spore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075233 +name: obsolete negative regulation of spore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of spore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075234 +name: obsolete zoospore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process involved in the directed movement of a zoospore on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "zoospore motility on or near host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075235 +name: obsolete modulation of zoospore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of zoospore movement on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +synonym: "regulation of zoospore motility on or near host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075236 +name: obsolete positive regulation of zoospore movement on or near host +namespace: biological_process +def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075237 +name: obsolete obsolete negative regulation of zoospore movement on or near host +namespace: biological_process +def: "OBSOLETE. OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore movement on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represented both a process and a location. +is_obsolete: true + +[Term] +id: GO:0075239 +name: zoospore formation +namespace: biological_process +def: "The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075240 +name: regulation of zoospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075241 +name: positive regulation of zoospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075240 ! regulation of zoospore formation +is_a: GO:0075287 ! positive regulation of sporangiospore formation +relationship: positively_regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075242 +name: negative regulation of zoospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore formation, a process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores." [GOC:pamgo_curators] +is_a: GO:0075240 ! regulation of zoospore formation +is_a: GO:0075288 ! negative regulation of sporangiospore formation +relationship: negatively_regulates GO:0075239 ! zoospore formation + +[Term] +id: GO:0075243 +name: oospore formation +namespace: biological_process +def: "The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi." [GOC:pamgo_curators] +is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075244 +name: regulation of oospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075245 +name: positive regulation of oospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075244 ! regulation of oospore formation +relationship: positively_regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075246 +name: negative regulation of oospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oospore formation, a process in which male and female gametangia develop and fuse to form a thick-walled resting spore of oomycetes." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075244 ! regulation of oospore formation +relationship: negatively_regulates GO:0075243 ! oospore formation + +[Term] +id: GO:0075247 +name: aeciospore formation +namespace: biological_process +def: "The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host." [GOC:pamgo_curators] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075248 +name: regulation of aeciospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075249 +name: positive regulation of aeciospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075248 ! regulation of aeciospore formation +relationship: positively_regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075250 +name: negative regulation of aeciospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075248 ! regulation of aeciospore formation +relationship: negatively_regulates GO:0075247 ! aeciospore formation + +[Term] +id: GO:0075251 +name: uredospore formation +namespace: biological_process +def: "The process which specific outcome is the formation of an asexual, dikaryotic, often rusty-colored spore, produced in a structure called a uredinium; mostly found in the rust fungus." [GOC:pamgo_curators] +synonym: "urediniospore formation" EXACT [] +synonym: "ureidospore formation" EXACT [] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075252 +name: regulation of uredospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +synonym: "regulation of ureidospore formation" EXACT [] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075251 ! uredospore formation + +[Term] +id: GO:0075253 +name: positive regulation of uredospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +synonym: "positive regulation of ureidospore formation" EXACT [] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075252 ! regulation of uredospore formation +relationship: positively_regulates GO:0075251 ! uredospore formation + +[Term] +id: GO:0075254 +name: negative regulation of uredospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." [GOC:pamgo_curators] +synonym: "negative regulation of ureidospore formation" EXACT [] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075252 ! regulation of uredospore formation +relationship: negatively_regulates GO:0075251 ! uredospore formation + +[Term] +id: GO:0075255 +name: teliospore formation +namespace: biological_process +def: "The set of processes leading to the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore + +[Term] +id: GO:0075256 +name: regulation of teliospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or over-wintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075257 +name: positive regulation of teliospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075256 ! regulation of teliospore formation +relationship: positively_regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075258 +name: negative regulation of teliospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of teliospore formation, which is the formation of a thick-walled resting or overwintering spore produced by the rust fungi (Uredinales) and smut fungi (Ustilaginales) in which karyogamy occurs." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075256 ! regulation of teliospore formation +relationship: negatively_regulates GO:0075255 ! teliospore formation + +[Term] +id: GO:0075259 +name: spore-bearing structure development +namespace: biological_process +def: "The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] +synonym: "fruiting structure development" EXACT [] +synonym: "sporangium development" BROAD [] +synonym: "spore-bearing organ development" RELATED [] +synonym: "sporophore development" EXACT [] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0075260 +name: regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075261 +name: positive regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0075260 ! regulation of spore-bearing organ development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075262 +name: negative regulation of spore-bearing organ development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." [GOC:pamgo_curators] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0075260 ! regulation of spore-bearing organ development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075263 +name: oogonium development +namespace: biological_process +def: "The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075264 +name: regulation of oogonium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075265 +name: positive regulation of oogonium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075264 ! regulation of oogonium development +relationship: positively_regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075266 +name: negative regulation of oogonium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oogonium development, a process that leads to the formation of a female gametangium of oomycetes, containing one or more gametes." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075264 ! regulation of oogonium development +relationship: negatively_regulates GO:0075263 ! oogonium development + +[Term] +id: GO:0075267 +name: aecium development +namespace: biological_process +def: "The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium." [GOC:pamgo_curators] +is_a: GO:0030582 ! reproductive fruiting body development + +[Term] +id: GO:0075268 +name: regulation of aecium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0031155 ! regulation of reproductive fruiting body development +relationship: regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075269 +name: positive regulation of aecium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075268 ! regulation of aecium development +relationship: positively_regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075270 +name: negative regulation of aecium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aecium development, a process in which a cuplike structure containing chains of aeciospores is formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075268 ! regulation of aecium development +relationship: negatively_regulates GO:0075267 ! aecium development + +[Term] +id: GO:0075271 +name: zygosporangium development +namespace: biological_process +def: "The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075272 +name: regulation of zygosporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075273 +name: positive regulation of zygosporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075272 ! regulation of zygosporangium development +relationship: positively_regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075274 +name: negative regulation of zygosporangium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygosporangium development, a process in which a fruiting body called zygosporangium is formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075272 ! regulation of zygosporangium development +relationship: negatively_regulates GO:0075271 ! zygosporangium development + +[Term] +id: GO:0075275 +name: telium development +namespace: biological_process +def: "The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075276 +name: regulation of telium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075275 ! telium development + +[Term] +id: GO:0075277 +name: positive regulation of telium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075276 ! regulation of telium development +relationship: positively_regulates GO:0075275 ! telium development + +[Term] +id: GO:0075278 +name: negative regulation of telium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of telium development, a process that leads to the formation of a teliospore-bearing sorus of the rust fungi." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075276 ! regulation of telium development +relationship: negatively_regulates GO:0075275 ! telium development + +[Term] +id: GO:0075279 +name: uredinium development +namespace: biological_process +def: "The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +synonym: "development of uredium" EXACT [] +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075280 +name: regulation of uredinium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075281 +name: positive regulation of uredinium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075280 ! regulation of uredinium development +relationship: positively_regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075282 +name: negative regulation of uredinium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of uredinium development, a process that leads to the formation of a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075280 ! regulation of uredinium development +relationship: negatively_regulates GO:0075279 ! uredinium development + +[Term] +id: GO:0075283 +name: sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure." [GOC:pamgo_curators] +synonym: "multicellular or syncytial spore formation by sporulation" EXACT [GOC:dph, GOC:tb] +is_a: GO:0043934 ! sporulation + +[Term] +id: GO:0075284 +name: asexual sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The formation of a multicellular or syncytial spore via septations derived from mitosis." [GOC:pamgo_curators] +is_a: GO:0030436 ! asexual sporulation +is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore + +[Term] +id: GO:0075285 +name: sexual sporulation resulting in formation of a multicellular or syncytial spore +namespace: biological_process +def: "The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] +is_a: GO:0034293 ! sexual sporulation +is_a: GO:0075283 ! sporulation resulting in formation of a multicellular or syncytial spore + +[Term] +id: GO:0075286 +name: regulation of sporangiospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043943 ! regulation of asexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075287 +name: positive regulation of sporangiospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043945 ! positive regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: positively_regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075288 +name: negative regulation of sporangiospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm." [GOC:pamgo_curators] +is_a: GO:0043944 ! negative regulation of asexual sporulation resulting in formation of a cellular spore +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: negatively_regulates GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075289 +name: aplanospore formation +namespace: biological_process +def: "The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0034300 ! sporangiospore formation + +[Term] +id: GO:0075290 +name: regulation of aplanospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075286 ! regulation of sporangiospore formation +relationship: regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075291 +name: positive regulation of aplanospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075287 ! positive regulation of sporangiospore formation +is_a: GO:0075290 ! regulation of aplanospore formation +relationship: positively_regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075292 +name: negative regulation of aplanospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of aplanospore formation, a process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell." [GOC:pamgo_curators] +is_a: GO:0075288 ! negative regulation of sporangiospore formation +is_a: GO:0075290 ! regulation of aplanospore formation +relationship: negatively_regulates GO:0075289 ! aplanospore formation + +[Term] +id: GO:0075293 +name: response to host pH environment +namespace: biological_process +def: "Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "response of symbiont to host pH environment" EXACT [] +is_a: GO:0075136 ! response to host + +[Term] +id: GO:0075294 +name: positive regulation by symbiont of entry into host +namespace: biological_process +alt_id: GO:0075295 +def: "Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "activation by organism of entry into other organism during symbiotic interaction" NARROW [] +synonym: "activation by symbiont of entry into host" NARROW [] +synonym: "positive regulation by organism of entry into other organism during symbiotic interaction" RELATED [GOC:tb] +synonym: "positive regulation by organism of entry into other organism involved in symbiotic interaction" RELATED [] +synonym: "up regulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "up regulation by symbiont of entry into host" EXACT [] +synonym: "up-regulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "up-regulation by symbiont of entry into host" EXACT [] +synonym: "upregulation by organism of entry into other organism during symbiotic interaction" RELATED [] +synonym: "upregulation by symbiont of entry into host" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: positively_regulates GO:0044409 ! entry into host + +[Term] +id: GO:0075296 +name: positive regulation of ascospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0034307 ! regulation of ascospore formation +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +relationship: positively_regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0075297 +name: negative regulation of ascospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascospore formation, a process in which a sexual spore, named ascospore, from Ascomycete fungi was produced inside an ascus." [GOC:pamgo_curators] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0034307 ! regulation of ascospore formation +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +relationship: negatively_regulates GO:0030437 ! ascospore formation + +[Term] +id: GO:0075298 +name: regulation of zygospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075299 +name: positive regulation of zygospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075298 ! regulation of zygospore formation +relationship: positively_regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075300 +name: negative regulation of zygospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of zygospore formation, a process in which a thick-walled spore of some algae and fungi is formed by union of two similar sexual cells, usually serves as a resting spore, and produces the sporophytic phase." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075298 ! regulation of zygospore formation +relationship: negatively_regulates GO:0034296 ! zygospore formation + +[Term] +id: GO:0075301 +name: obsolete cell differentiation involved in spore germination +namespace: biological_process +def: "OBSOLETE. The process in which a relatively unspecialized cell acquires specialized features of a specific cell type occurring during spore germination, the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth." [GOC:jl] +comment: This term was made obsolete because it describes a process that doesn't exist. +is_obsolete: true + +[Term] +id: GO:0075302 +name: regulation of basidiospore formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi Basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043940 ! regulation of sexual sporulation resulting in formation of a cellular spore +relationship: regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0075303 +name: positive regulation of basidiospore formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043941 ! positive regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075302 ! regulation of basidiospore formation +relationship: positively_regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0075304 +name: negative regulation of basidiospore formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidiospore formation, a process in which a sexually produced fungal spore is formed on a basidium in the fungi basidiomycetes." [GOC:pamgo_curators] +is_a: GO:0043942 ! negative regulation of sexual sporulation resulting in formation of a cellular spore +is_a: GO:0075302 ! regulation of basidiospore formation +relationship: negatively_regulates GO:0034295 ! basidiospore formation + +[Term] +id: GO:0075305 +name: obsolete modulation of growth or development of symbiont on or near host +namespace: biological_process +def: "OBSOLETE. Any process by which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "modulation of growth or development of symbiont on or near host" EXACT [] +synonym: "modulation of growth or development of symbiont on or near host surface" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075306 +name: regulation of conidium formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] +is_a: GO:0034305 ! regulation of asexual sporulation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075307 +name: positive regulation of conidium formation +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0075306 ! regulation of conidium formation +is_a: GO:1903666 ! positive regulation of asexual reproduction +relationship: positively_regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075308 +name: negative regulation of conidium formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus." [GOC:di, GOC:pamgo_curators] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0075306 ! regulation of conidium formation +is_a: GO:1903665 ! negative regulation of asexual reproduction +relationship: negatively_regulates GO:0048315 ! conidium formation + +[Term] +id: GO:0075309 +name: obsolete negative regulation of growth or development of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "negative regulation of growth or development of symbiont on or near host surface" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075310 +name: regulation of sporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075311 +name: positive regulation of sporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075310 ! regulation of sporangium development +relationship: positively_regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075312 +name: negative regulation of sporangium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sporangium development, a process that leads to the formation of sporangium, a single-celled or many-celled structure in which spores are produced, as in fungi, algae, mosses, and ferns, gymnosperms, angiosperms." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075310 ! regulation of sporangium development +relationship: negatively_regulates GO:0043582 ! sporangium development + +[Term] +id: GO:0075313 +name: basidium development +namespace: biological_process +def: "The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] +comment: Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075314 +name: regulation of basidium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basidium development, a process that leads to the formation of a basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075315 +name: positive regulation of basidium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075314 ! regulation of basidium development +relationship: positively_regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075316 +name: negative regulation of basidium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of basidium development, a process that leads to the formation of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to basidiomycetes and distinguishes them from other kinds of fungi." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075314 ! regulation of basidium development +relationship: negatively_regulates GO:0075313 ! basidium development + +[Term] +id: GO:0075317 +name: ascus development +namespace: biological_process +def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] +comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. +is_a: GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0075318 +name: regulation of ascus development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ascus development, a process that leads to the formation of basidium, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075260 ! regulation of spore-bearing organ development +relationship: regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075319 +name: positive regulation of ascus development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:0075318 ! regulation of ascus development +relationship: positively_regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075320 +name: negative regulation of ascus development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ascus development, a saclike structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:pamgo_curators] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:0075318 ! regulation of ascus development +relationship: negatively_regulates GO:0075317 ! ascus development + +[Term] +id: GO:0075321 +name: oomycete sporangium development +namespace: biological_process +def: "The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0030436 ! asexual sporulation +is_a: GO:0043582 ! sporangium development + +[Term] +id: GO:0075322 +name: regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0034305 ! regulation of asexual sporulation +is_a: GO:0075310 ! regulation of sporangium development +relationship: regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075323 +name: positive regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0043938 ! positive regulation of sporulation +is_a: GO:0075311 ! positive regulation of sporangium development +is_a: GO:0075322 ! regulation of oomycete sporangium development +is_a: GO:1903666 ! positive regulation of asexual reproduction +relationship: positively_regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075324 +name: negative regulation of oomycete sporangium development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oomycete sporangium development, a process that leads to the formation of oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiate, through specialized cleavage vesicles, into between 10 and 30 zoospores, which is laterally flagellated." [GOC:pamgo_curators] +is_a: GO:0043939 ! negative regulation of sporulation +is_a: GO:0075312 ! negative regulation of sporangium development +is_a: GO:0075322 ! regulation of oomycete sporangium development +is_a: GO:1903665 ! negative regulation of asexual reproduction +relationship: negatively_regulates GO:0075321 ! oomycete sporangium development + +[Term] +id: GO:0075325 +name: spore dispersal +namespace: biological_process +alt_id: GO:0075326 +alt_id: GO:0075327 +def: "Any process in which an organism disseminates its spores." [Wikipedia:Spore] +synonym: "active spore dispersal on or near host" NARROW [] +synonym: "active spore dispersal on or near host during symbiotic interaction" NARROW [] +synonym: "passive spore dispersal on or near host" NARROW [] +synonym: "spore dispersal on or near host" NARROW [] +synonym: "spore dispersal on or near host during symbiotic interaction" EXACT [] +is_a: GO:0000003 ! reproduction + +[Term] +id: GO:0075328 +name: formation of arbuscule for nutrient acquisition +namespace: biological_process +def: "The assembly of an arbuscule, a fine, tree-like hyphal symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +synonym: "formation by symbiont of arbuscule for nutrient acquisition from host" RELATED [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition + +[Term] +id: GO:0075329 +name: regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:0044145 ! modulation of formation of structure involved in a symbiotic process +is_a: GO:0060259 ! regulation of feeding behavior +relationship: regulates GO:0075328 ! formation of arbuscule for nutrient acquisition + +[Term] +id: GO:0075330 +name: positive regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044149 ! positive regulation of formation of structure involved in a symbiotic process +is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host +relationship: positively_regulates GO:0075328 ! formation of arbuscule for nutrient acquisition + +[Term] +id: GO:0075331 +name: negative regulation of arbuscule formation for nutrient acquisition from host +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. +is_a: GO:0044147 ! negative regulation of formation of structure involved in a symbiotic process +is_a: GO:0075329 ! regulation of arbuscule formation for nutrient acquisition from host +relationship: negatively_regulates GO:0075328 ! formation of arbuscule for nutrient acquisition + +[Term] +id: GO:0075332 +name: obsolete modulation by host of symbiont adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075333 +name: obsolete positive regulation by host of symbiont adenylate cyclase-mediated signal transduction +namespace: biological_process +def: "OBSOLETE. Any process in which the host organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. +is_obsolete: true + +[Term] +id: GO:0075334 +name: obsolete modulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism modulates the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075335 +name: obsolete positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism activates, maintains or increases the frequency, rate or extent of its adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075336 +name: obsolete negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host +namespace: biological_process +def: "OBSOLETE. Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of its symbiont adenylate cyclase-mediated signal transduction as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0075337 +name: obsolete positive regulation of growth or development of symbiont on or near host surface +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass, or its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:pamgo_curators] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "positive regulation of growth or development of symbiont on or near host surface" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075338 +name: obsolete modulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "modulation of growth or development of symbiont during interaction with host" EXACT [] +is_obsolete: true +consider: GO:0044145 + +[Term] +id: GO:0075339 +name: obsolete positive regulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "positive regulation of growth or development of symbiont during interaction with host" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075340 +name: obsolete negative regulation of growth or development of symbiont during interaction with host +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl] +comment: This term was made obsolete because it contained a conjunction (or). +synonym: "negative regulation of growth or development of symbiont during interaction with host" EXACT [] +is_obsolete: true +consider: GO:0044147 + +[Term] +id: GO:0075341 +name: host cell PML body +namespace: cellular_component +def: "A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism." [GOC:BHF, GOC:jl] +synonym: "host cell PML NB" EXACT [] +synonym: "host cell PML nuclear body" EXACT [] +is_a: GO:0044094 ! host cell nuclear part + +[Term] +id: GO:0075342 +name: disruption by symbiont of host cell PML body +namespace: biological_process +def: "The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:BHF, GOC:jl] +synonym: "catabolism by symbiont of host cell PML body" EXACT [] +synonym: "degradation by symbiont of host cell PML body" EXACT [] +synonym: "disassembly by symbiont of host cell PML body" EXACT [] +synonym: "disassembly by symbiont of host cell PML body during symbiotic interaction" EXACT [] +synonym: "disassembly by symbiont of host cell PML NB" EXACT [] +synonym: "disassembly by symbiont of host cell PML nuclear body" EXACT [] +is_a: GO:0052008 ! disruption by symbiont of host cellular component + +[Term] +id: GO:0075343 +name: modulation by symbiont of abscisic acid levels in host +namespace: biological_process +def: "The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'. +is_a: GO:0052019 ! modulation by symbiont of host hormone or growth regulator levels + +[Term] +id: GO:0075344 +name: obsolete modulation by symbiont of host protein levels +namespace: biological_process +def: "OBSOLETE. The alteration by an organism of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:0075345 +name: obsolete modification by symbiont of host protein +namespace: biological_process +def: "OBSOLETE. The covalent alteration by an organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0075346 +name: obsolete modification by symbiont of host protein by ubiquitination +namespace: biological_process +def: "OBSOLETE. The process in which an organism adds one or more ubiquitin groups to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it represents a molecular function. +synonym: "modification by symbiont of host protein by ubiquitinylation" EXACT [] +synonym: "modification by symbiont of host protein by ubiquitylation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075502 +name: endosome membrane permeabilization involved in viral entry into host cell +namespace: biological_process +alt_id: GO:0075518 +def: "Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm." [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane" RELATED [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization" RELATED [GOC:bf, GOC:jl] +is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell + +[Term] +id: GO:0075503 +name: fusion of virus membrane with host macropinosome membrane +namespace: biological_process +def: "Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm." [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane" EXACT [] +synonym: "viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane" RELATED [GOC:bf, GOC:jl] +is_a: GO:0039654 ! fusion of virus membrane with host endosome membrane + +[Term] +id: GO:0075504 +name: macropinosomal membrane permeabilization involved in viral entry into host cell +namespace: biological_process +def: "Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization" RELATED [GOC:bf, GOC:jl] +is_a: GO:0039665 ! permeabilization of host organelle membrane involved in viral entry into host cell + +[Term] +id: GO:0075505 +name: entry of intact viral capsid into host nucleus through nuclear pore complex +namespace: biological_process +def: "Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC)." [PMID:22929056, VZ:989] +comment: This mechanism is used by viruses with capsids small enough to cross the nuclear pore complex, such as the single-stranded (ss) DNA viruses Parvoviridae, Circoviridae and Geminiviridae. +is_a: GO:0075732 ! viral penetration into host nucleus + +[Term] +id: GO:0075506 +name: entry of viral genome into host nucleus through nuclear pore complex via importin +namespace: biological_process +def: "Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery." [PMID:22929056, VZ:989] +comment: This mechanism is used by some RNA viruses (e.g. Orthomyxoviridae), some dsDNA viruses (e.g. Polyomaviridae) and some ssRNA viruses (e.g. Lentivirus). +synonym: "entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex" EXACT [GOC:jl] +is_a: GO:0075732 ! viral penetration into host nucleus + +[Term] +id: GO:0075507 +name: entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome +namespace: biological_process +def: "Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm." [PMID:22929056, VZ:989] +comment: This mechanism is used by viruses such as Herpesvirales whose capsid is too large to enter the nuclear pore complex (NPC) pore. +is_a: GO:0075732 ! viral penetration into host nucleus + +[Term] +id: GO:0075508 +name: entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm +namespace: biological_process +def: "Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm." [PMID:22929056, VZ:989] +comment: This mechanism is used by viruses such as Hepadnaviridae whose capsids enter the NPC but are too big to pass intact into the nucleus. +synonym: "entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm" EXACT [GOC:jl] +is_a: GO:0075732 ! viral penetration into host nucleus + +[Term] +id: GO:0075509 +name: endocytosis involved in viral entry into host cell +namespace: biological_process +def: "Any endocytosis that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, VZ:977] +synonym: "viral entry into host cell via endocytosis" RELATED [GOC:bf, GOC:jl] +synonym: "viral penetration via endocytosis followed by endosome disruption" EXACT [] +synonym: "virus endocytosis by host" EXACT [UniProtKB-KW:KW-1164] +xref: VZ:977 "Virus endocytosis by host" +is_a: GO:0006897 ! endocytosis +is_a: GO:0046794 ! transport of virus +relationship: part_of GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0075510 +name: macropinocytosis involved in viral entry into host cell +namespace: biological_process +def: "Any macropinocytosis that is involved in the uptake of a virus into a host cell." [GOC:jl, GOC:sp, PMID:17077125, PMID:19404330, VZ:800] +synonym: "viral entry into host cell via macropinocytosis" RELATED [GOC:bf, GOC:jl] +xref: VZ:800 "Macropinocytosis of virus by host" +is_a: GO:0075509 ! endocytosis involved in viral entry into host cell + +[Term] +id: GO:0075511 +name: macropinosome lysis involved in viral entry into host cell +namespace: biological_process +def: "Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm." [GOC:bf, GOC:jl] +is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell + +[Term] +id: GO:0075512 +name: clathrin-dependent endocytosis of virus by host cell +namespace: biological_process +alt_id: GO:0075516 +def: "Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus." [GOC:bf, GOC:jl, VZ:957] +synonym: "clathrin-mediated endocytosis of virus by host cell" EXACT [] +synonym: "viral entry into host cell via clathrin-mediated endocytosis" RELATED [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis" NARROW [] +synonym: "viral penetration via clathrin-mediated endocytosis" EXACT [GOC:sp] +xref: VZ:957 "Clathrin-mediated endocytosis of virus by host" +is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell +is_a: GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:0075513 +name: caveolin-mediated endocytosis of virus by host cell +namespace: biological_process +def: "Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus." [GOC:bf, GOC:jl, VZ:976] +synonym: "viral entry into host cell via caveolae-mediated endocytosis" EXACT [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via caveolin-mediated endocytosis" RELATED [GOC:bf, GOC:jl] +synonym: "viral penetration via caveolae-mediated endocytosis followed by endosome disruption" EXACT [] +xref: VZ:976 "Caveolin-mediated endocytosis of virus by host" +is_a: GO:0019065 ! receptor-mediated endocytosis of virus by host cell +is_a: GO:0072584 ! caveolin-mediated endocytosis + +[Term] +id: GO:0075514 +name: endosome lysis involved in viral entry into host cell +namespace: biological_process +def: "Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm." [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis" EXACT [GOC:bf, GOC:jl] +is_a: GO:0039664 ! lysis of host organelle involved in viral entry into host cell + +[Term] +id: GO:0075515 +name: obsolete viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane +namespace: biological_process +def: "OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl, VZ:976] +comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis. +synonym: "viral entry into host cell via caveolae-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [GOC:bf, GOC:jl] +synonym: "viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075519 +name: microtubule-dependent intracellular transport of viral material +namespace: biological_process +def: "The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus." [VZ:983] +is_a: GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:0075520 +name: actin-dependent intracellular transport of virus +namespace: biological_process +def: "The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions." [UniProtKB-KW:KW-1178, VZ:991] +synonym: "actin-dependent intracellular transport of viral material" EXACT [] +xref: VZ:991 "Actin-dependent inwards viral transport" +is_a: GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:0075521 +name: microtubule-dependent intracellular transport of viral material towards nucleus +namespace: biological_process +def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules." [UniProtKB-KW:KW-1177, VZ:983] +synonym: "microtubule-dependent intracellular transport of viral material to nucleus" EXACT [GOC:jl] +xref: VZ:983 "Microtubular inwards viral transport" +is_a: GO:0075519 ! microtubule-dependent intracellular transport of viral material +is_a: GO:0075606 ! transport of viral material towards nucleus + +[Term] +id: GO:0075522 +name: IRES-dependent viral translational initiation +namespace: biological_process +def: "Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation." [GOC:bf, GOC:jl, PMID:19632368, VZ:867] +xref: VZ:867 "Viral initiation of translation: IRES and DLP" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019081 ! viral translation + +[Term] +id: GO:0075523 +name: viral translational frameshifting +namespace: biological_process +def: "A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins." [GOC:bf, GOC:ch, GOC:jl, PMID:24825891, PMID:8852897, VZ:860] +comment: This term is intended to annotate gene products involved in the process of viral translational frameshifting, not viral proteins produced by this translation process. +synonym: "ribosomal frameshifting involved in viral translation" EXACT [GOC:jl] +xref: VZ:860 "Ribosomal frameshifting" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019081 ! viral translation + +[Term] +id: GO:0075524 +name: ribosomal skipping +namespace: biological_process +def: "A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue." [GOC:bf, GOC:ch, GOC:jl, VZ:914] +comment: This term is intended to annotate gene products involved in the process of ribosomal skipping, not viral proteins produced by this translation process. +xref: VZ:914 "Ribosomal skipping" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019081 ! viral translation + +[Term] +id: GO:0075525 +name: viral translational termination-reinitiation +namespace: biological_process +def: "A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF." [GOC:bf, GOC:ch, GOC:jl, PMID:18631147, PMID:18824510, VZ:858] +comment: This term is intended to annotate gene products involved in the process of viral translational termination-reinitiation, not viral proteins produced by this translation process. +synonym: "termination reinitiation involved in viral translation" EXACT [GO:jl] +synonym: "viral translation involving termination re-initiation" EXACT [GO:jl] +synonym: "viral translation involving termination-reinitiation" EXACT [GO:jl] +synonym: "viral translation involving translational stop-start" EXACT [GO:jl] +xref: VZ:858 "RNA termination-reinitiation" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019081 ! viral translation + +[Term] +id: GO:0075526 +name: cap snatching +namespace: biological_process +def: "A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs." [GOC:bf, GOC:jl, VZ:839] +synonym: "cap snatching involved in viral mRNA transcription" EXACT [GO:jl] +xref: VZ:839 +is_a: GO:0016032 ! viral process +relationship: part_of GO:0039697 ! negative stranded viral RNA transcription + +[Term] +id: GO:0075527 +name: viral RNA editing +namespace: biological_process +def: "The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon." [PMID:1629949, VZ:857] +synonym: "RNA editing involved in viral mRNA transcription" EXACT [GO:jl] +xref: VZ:857 "RNA editing" +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019083 ! viral transcription + +[Term] +id: GO:0075528 +name: modulation by virus of host immune response +namespace: biological_process +def: "The process in which a virus effects a change in the host immune response." [GOC:bf, GOC:jl] +synonym: "regulation by virus of host immune system process" EXACT [GOC:jl] +is_a: GO:0019054 ! modulation by virus of host cellular process +is_a: GO:0052553 ! modulation by symbiont of host immune response +relationship: regulates GO:0006955 ! immune response + +[Term] +id: GO:0075529 +name: establishment of latency as a circular episome +namespace: biological_process +def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure." [GOC:jl] +synonym: "establishment of circular plasmid latency" EXACT [] +synonym: "establishment of latency as a circular plasmid" EXACT [] +is_a: GO:0075720 ! establishment of episomal latency + +[Term] +id: GO:0075530 +name: establishment of latency as a linear episome +namespace: biological_process +def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure." [GOC:jl] +synonym: "establishment of latency as a linear plasmid" EXACT [] +synonym: "establishment of linear plasmid latency" EXACT [] +is_a: GO:0075720 ! establishment of episomal latency + +[Term] +id: GO:0075606 +name: transport of viral material towards nucleus +namespace: biological_process +def: "The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane." [GOC:bf, GOC:jl, VZ:990] +comment: This process does not include the viral material crossing the nuclear membrane. For transport of viral material into the nucleus, consider instead: 'viral penetration into host nucleus ; GO:0075732'. +synonym: "cytoplasmic inwards viral transport" EXACT [UniProtKB-KW:KW-1176, VZ:990] +synonym: "transport of viral material to nucleus" EXACT [GOC:jl] +synonym: "viral genome transport to host cell nucleus" EXACT [] +xref: VZ:990 "Cytoplasmic inwards viral transport" +is_a: GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:0075705 +name: obsolete viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane +namespace: biological_process +def: "OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane." [GOC:jl] +comment: This term was made obsolete because it doesn't represent a genuine process. The term injection is mostly used for prokaryotic viruses where there is no endocytosis. +synonym: "viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane" EXACT [] +synonym: "viral penetration via endocytosis followed by genetic injection through the endosome membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:0075713 +name: establishment of integrated proviral latency +namespace: biological_process +alt_id: GO:0019047 +def: "A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage." [GOC:jl] +synonym: "prophage integration" EXACT [] +synonym: "provirus integration" EXACT [] +xref: VZ:980 "Viral genome integration" +is_a: GO:0019043 ! establishment of viral latency + +[Term] +id: GO:0075720 +name: establishment of episomal latency +namespace: biological_process +def: "A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity." [GOC:jl] +synonym: "establishment as a plasmid prophage" NARROW [] +synonym: "establishment of plasmid latency" EXACT [] +is_a: GO:0019043 ! establishment of viral latency + +[Term] +id: GO:0075732 +name: viral penetration into host nucleus +namespace: biological_process +def: "The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid." [PMID:22929056, VZ:989] +synonym: "viral entry into host nucleus" EXACT [] +synonym: "viral import into host nucleus" EXACT [] +xref: VZ:989 "Viral penetration into host nucleus" +is_a: GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:0075733 +name: intracellular transport of virus +namespace: biological_process +alt_id: GO:0046788 +alt_id: GO:0046795 +alt_id: GO:0046796 +def: "The directed movement of a virus, or part of a virus, within the host cell." [GOC:ai, GOC:bf, GOC:jl, PMID:11733033] +synonym: "egress of virus within host cell" EXACT [] +synonym: "intracellular transport of viral material" EXACT [GOC:bf, GOC:jl] +synonym: "intracellular virion transport" RELATED [] +synonym: "movement of virus within host cell" EXACT [] +synonym: "viral egress" RELATED [] +synonym: "viral genome transport in host cell" EXACT [] +is_a: GO:0046794 ! transport of virus +relationship: part_of GO:0019058 ! viral life cycle + +[Term] +id: GO:0080001 +name: mucilage extrusion from seed coat +namespace: biological_process +def: "The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat." [PMID:18266922] +synonym: "mucilage release from seed coat" RELATED [] +synonym: "secretion of mucilage from seed coat" RELATED [] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0009845 ! seed germination +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0080002 +name: UDP-glucose:4-aminobenzoate acylglucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP." [EC:2.4.1.-, PMID:18385129] +synonym: "UDP-glucose:p-aminobenzoate acylglucosyltransferase activity" RELATED [] +synonym: "UDP-glucose:p-aminobenzoate glucosyltransferase activity" RELATED [] +synonym: "UDP-glucose:pABA acylglucosyltransferase activity" RELATED [] +xref: MetaCyc:RXN-6142 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080003 +name: thalianol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the triterpene thalianol." [PMID:18356490] +synonym: "thalianol metabolism" EXACT [GOC:tair_curators] +is_a: GO:0010683 ! tricyclic triterpenoid metabolic process + +[Term] +id: GO:0080004 +name: thalian-diol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15." [PMID:18356490] +xref: EC:1.14.21.- +xref: MetaCyc:RXN-9637 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0080005 +name: photosystem stoichiometry adjustment +namespace: biological_process +def: "Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis." [PMID:11607105] +is_a: GO:0010109 ! regulation of photosynthesis + +[Term] +id: GO:0080006 +name: internode patterning +namespace: biological_process +def: "Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached." [GOC:tb] +is_a: GO:0007389 ! pattern specification process +relationship: part_of GO:0048367 ! shoot system development + +[Term] +id: GO:0080007 +name: S-nitrosoglutathione reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+." [MetaCyc:RXN-10742, PMID:11260719] +xref: MetaCyc:RXN-10742 +is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor + +[Term] +id: GO:0080008 +name: Cul4-RING E3 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:16792691, PMID:18223036, PMID:18552200] +is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex + +[Term] +id: GO:0080009 +name: mRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule." [PMID:18505803] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0016556 ! mRNA modification + +[Term] +id: GO:0080010 +name: obsolete regulation of oxygen and reactive oxygen species metabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [PMID:18450450] +comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. +synonym: "regulation of oxygen and reactive oxygen species metabolic process" EXACT [] +is_obsolete: true +consider: GO:2000374 +consider: GO:2000377 + +[Term] +id: GO:0080011 +name: baruol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol." [PMID:17705488, RHEA:31987] +xref: EC:5.4.99.57 +xref: MetaCyc:RXN-9685 +xref: RHEA:31987 +is_a: GO:0031559 ! oxidosqualene cyclase activity + +[Term] +id: GO:0080012 +name: trihydroxyferuloyl spermidine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+." [PMID:18557837] +synonym: "N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity" EXACT [MetaCyc:RXN-11263] +xref: MetaCyc:RXN-11263 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080013 +name: (E,E)-geranyllinalool synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate." [MetaCyc:RXN-10441, PMID:18398052] +xref: MetaCyc:RXN-10441 +xref: RHEA:38155 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0080014 +name: thalianol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X." [MetaCyc:RXN-9631, PMID:17474751, PMID:18356490] +comment: In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008). +xref: EC:1.14.13.- +xref: MetaCyc:RXN-9631 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0080015 +name: sabinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate." [MetaCyc:RXN-5103, PMID:12566586, PMID:9747540] +xref: EC:4.2.3.- +xref: MetaCyc:RXN-5103 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0080016 +name: (-)-E-beta-caryophyllene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate." [MetaCyc:RXN-8414, PMID:12566586, PMID:9442047] +xref: EC:4.2.3.57 +xref: MetaCyc:RXN-8414 +xref: RHEA:28294 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0080017 +name: alpha-humulene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate." [PMID:12566586, PMID:9442047, RHEA:31895] +xref: EC:4.2.3.104 +xref: MetaCyc:RXN-8415 +xref: RHEA:31895 +is_a: GO:0009975 ! cyclase activity +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0080018 +name: anthocyanin 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP." [PMID:15807784] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080019 +name: fatty-acyl-CoA reductase (alcohol-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA." [PMID:16980563] +synonym: "fatty acyl CoA reductase (alcohol-forming) activity" EXACT [] +synonym: "fatty acyl-CoA reductase (alcohol-forming) activity" EXACT [GOC:mah] +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0080020 +name: regulation of coenzyme A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzyme A." [PMID:18621975] +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +relationship: regulates GO:0015937 ! coenzyme A biosynthetic process + +[Term] +id: GO:0080021 +name: response to benzoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus." [PMID:18753285] +synonym: "response to benzoic acid stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0080022 +name: primary root development +namespace: biological_process +def: "The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle." [GOC:dhl] +is_a: GO:0048364 ! root development + +[Term] +id: GO:0080023 +name: 3R-hydroxyacyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O." [PMID:16982622] +xref: Reactome:R-HSA-5676637 "PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA" +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0080024 +name: indolebutyric acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants." [PMID:18725356] +synonym: "IBA metabolic process" EXACT [] +synonym: "IBA metabolism" EXACT [] +synonym: "indole-3-butyric acid metabolic process" NARROW [] +is_a: GO:0009850 ! auxin metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:0080025 +name: phosphatidylinositol-3,5-bisphosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." [GOC:bf, PMID:18397324] +synonym: "PtdIns(3,5)P2 binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding + +[Term] +id: GO:0080026 +name: response to indolebutyric acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus." [PMID:18725356] +synonym: "response to IBA stimulus" EXACT [] +synonym: "response to indole-3-butyric acid stimulus" NARROW [] +synonym: "response to indolebutyric acid stimulus" EXACT [GOC:dos] +is_a: GO:0009733 ! response to auxin +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0080027 +name: response to herbivore +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore." [PMID:18987211] +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0080028 +name: nitrile biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [PMID:18987211] +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:0050898 ! nitrile metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0080029 +name: cellular response to boron-containing substance levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances." [PMID:18952773] +synonym: "cellular response to boron levels" EXACT [] +is_a: GO:0010036 ! response to boron-containing substance +is_a: GO:0031669 ! cellular response to nutrient levels +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0080030 +name: methyl indole-3-acetate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+." [MetaCyc:RXN-10711, PMID:18467465] +synonym: "indole-3-Acetic acid methyl ester esterase activity" EXACT [] +synonym: "MeIAA esterase activity" EXACT [] +synonym: "Methyl IAA esterase activity" EXACT [] +xref: EC:3.1.1.1 +xref: MetaCyc:RXN-10711 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0080031 +name: methyl salicylate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+." [MetaCyc:RXNQT-4366, PMID:18467465, PMID:18643994] +synonym: "MESA esterase activity" EXACT [] +synonym: "methyl SA esterase activity" EXACT [] +synonym: "methylsalicylate esterase activity" EXACT [] +synonym: "salicylic acid methyl ester esterase activity" EXACT [] +xref: MetaCyc:RXNQT-4366 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0080032 +name: methyl jasmonate esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol." [PMID:15233793, PMID:18467465] +synonym: "jasmonic acid methyl ester esterase activity" EXACT [] +synonym: "MEJA esterase activity" EXACT [] +synonym: "methyl JA esterase activity" EXACT [] +xref: MetaCyc:RXN-10767 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0080033 +name: response to nitrite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus." [GOC:dhl, PMID:17951451] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0080034 +name: host response to induction by symbiont of tumor, nodule or growth in host +namespace: biological_process +def: "Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:18836040] +is_a: GO:0009608 ! response to symbiont + +[Term] +id: GO:0080035 +name: 2-hydroxy-but-3-enyl glucosinolate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of progoitrin, a 2-hydroxy-but-3-enyl glucosinolate. Glucosinolates are substituted thioglucosides found in rapeseed products and related cruciferae, and progoitrin has been implicated in causing goiters in mammals and bitter taste in cruciferous vegetables." [PMID:11560911, PMID:18945935] +synonym: "2-hydroxy-but-3-enyl glucosinolate anabolism" EXACT [] +synonym: "2-hydroxy-but-3-enyl glucosinolate biosynthesis" EXACT [] +synonym: "2-hydroxy-but-3-enyl glucosinolate formation" EXACT [] +synonym: "2-hydroxy-but-3-enyl glucosinolate synthesis" EXACT [] +synonym: "progoitrin biosynthesis" EXACT [] +synonym: "progoitrin biosynthetic process" EXACT [] +synonym: "progoitrin synthesis" EXACT [] +is_a: GO:0019761 ! glucosinolate biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0080036 +name: regulation of cytokinin-activated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytokinin signaling." [GOC:dhl] +synonym: "regulation of cytokinin mediated signaling pathway" RELATED [] +synonym: "regulation of cytokinin mediated signalling" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009736 ! cytokinin-activated signaling pathway + +[Term] +id: GO:0080037 +name: negative regulation of cytokinin-activated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cytokinin signaling." [GOC:dhl, PMID:14973166] +synonym: "negative regulation of cytokinin mediated signaling pathway" RELATED [] +synonym: "negative regulation of cytokinin mediated signalling" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway +relationship: negatively_regulates GO:0009736 ! cytokinin-activated signaling pathway + +[Term] +id: GO:0080038 +name: positive regulation of cytokinin-activated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytokinin signaling." [GOC:dhl] +synonym: "positive regulation of cytokinin mediated signaling pathway" RELATED [] +synonym: "positive regulation of cytokinin mediated signalling" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0080036 ! regulation of cytokinin-activated signaling pathway +relationship: positively_regulates GO:0009736 ! cytokinin-activated signaling pathway + +[Term] +id: GO:0080040 +name: positive regulation of cellular response to phosphate starvation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to phosphate starvation." [PMID:18315545] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:0140255 ! regulation of cellular response to phosphate starvation +relationship: positively_regulates GO:0016036 ! cellular response to phosphate starvation + +[Term] +id: GO:0080041 +name: ADP-ribose pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate." [GOC:tb] +is_a: GO:0019144 ! ADP-sugar diphosphatase activity + +[Term] +id: GO:0080042 +name: ADP-glucose pyrophosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate." [GOC:tb] +is_a: GO:0019144 ! ADP-sugar diphosphatase activity + +[Term] +id: GO:0080043 +name: quercetin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule." [PMID:15352060] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080044 +name: quercetin 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule." [PMID:15352060] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080045 +name: quercetin 3'-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule." [PMID:15352060] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080046 +name: quercetin 4'-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule." [PMID:15352060] +xref: MetaCyc:RXN-10788 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080047 +name: GDP-L-galactose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP." [EC:2.7.7.69, PMID:18463094] +xref: EC:2.7.7.69 +xref: MetaCyc:RXNQT-4141 +xref: RHEA:27698 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0080048 +name: GDP-D-glucose phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP." [PMID:18463094] +xref: EC:2.7.7.78 +xref: MetaCyc:RXN-12486 +xref: RHEA:30387 +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0080049 +name: L-gulono-1,4-lactone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [PMID:18190525] +xref: MetaCyc:RXN-1439 +is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor + +[Term] +id: GO:0080050 +name: regulation of seed development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seed development." [PMID:19141706] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048316 ! seed development + +[Term] +id: GO:0080051 +name: cutin transport +namespace: biological_process +def: "The directed movement of cutin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cutin, which consists of C16-18 fatty acids, is the major component of the cuticle that covers the plant surface." [PMID:17951461] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:0080052 +name: response to histidine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus." [PMID:15889294] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:0080053 +name: response to phenylalanine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylalanine stimulus." [PMID:15889294] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:0080054 +name: low-affinity nitrate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [PMID:19050168] +synonym: "low affinity nitrate transmembrane transporter activity" EXACT [] +is_a: GO:0015112 ! nitrate transmembrane transporter activity + +[Term] +id: GO:0080056 +name: petal vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the petal of vascular plants." [PMID:17369435] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0080057 +name: sepal vascular tissue pattern formation +namespace: biological_process +def: "Vascular tissue pattern formation as it occurs in the sepal of vascular plants." [PMID:17369435] +is_a: GO:0010051 ! xylem and phloem pattern formation + +[Term] +id: GO:0080058 +name: protein deglutathionylation +namespace: biological_process +def: "The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage." [GOC:tb] +synonym: "protein amino acid deglutathionylation" EXACT [GOC:bf] +is_a: GO:0006464 ! cellular protein modification process + +[Term] +id: GO:0080059 +name: flavonol 3-O-arabinosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside." [PMID:18757557] +is_a: GO:0008194 ! UDP-glycosyltransferase activity +is_a: GO:0052636 ! arabinosyltransferase activity + +[Term] +id: GO:0080060 +name: integument development +namespace: biological_process +def: "The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex." [PMID:19054366, PO:0020021] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009888 ! tissue development +relationship: part_of GO:0048481 ! plant ovule development + +[Term] +id: GO:0080061 +name: indole-3-acetonitrile nitrilase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3." [RHEA:45776] +xref: EC:3.5.5.1 +xref: MetaCyc:RXN-1404 +xref: RHEA:45776 +is_a: GO:0000257 ! nitrilase activity + +[Term] +id: GO:0080062 +name: cytokinin 9-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event." [KEGG_REACTION:R08369, PMID:15342621] +xref: KEGG_REACTION:R08369 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0080064 +name: 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation +namespace: biological_process +def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780] +synonym: "4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity" RELATED [] +is_a: GO:0034440 ! lipid oxidation + +[Term] +id: GO:0080065 +name: 4-alpha-methyl-delta7-sterol oxidation +namespace: biological_process +def: "A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O." [GOC:pr, PMID:14653780] +synonym: "4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity" RELATED [] +is_a: GO:0034440 ! lipid oxidation + +[Term] +id: GO:0080066 +name: 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXN-2209 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080067 +name: 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXNQT-4329 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080068 +name: 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXNQT-4330 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080069 +name: 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXNQT-4332 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080070 +name: 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXNQT-4333 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080071 +name: indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate." [PMID:19077143] +xref: MetaCyc:RXN-1443 +is_a: GO:0047364 ! desulfoglucosinolate sulfotransferase activity + +[Term] +id: GO:0080072 +name: spermidine:sinapoyl CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0080073 +name: spermidine:coumaroyl CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0080074 +name: spermidine:caffeoyl CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0080075 +name: spermidine:feruloyl CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule." [PMID:19077165] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0080076 +name: caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule." [PMID:19077165] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080077 +name: trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule." [PMID:19077165] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080078 +name: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule." [PMID:19077165] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080079 +name: cellobiose glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cellobiose + H2O = 2 D-glucose." [PMID:15604686] +synonym: "cellobiose glucohydrolase activity" EXACT [] +xref: MetaCyc:RXN-10773 +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0080081 +name: 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside." [PMID:15604686] +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0080082 +name: esculin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucosidic link in esculin." [PMID:15604686] +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0080083 +name: beta-gentiobiose beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose." [PMID:15604686] +is_a: GO:0008422 ! beta-glucosidase activity + +[Term] +id: GO:0080084 +name: 5S rDNA binding +namespace: molecular_function +def: "Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists." [PMID:12711688] +is_a: GO:0000182 ! rDNA binding + +[Term] +id: GO:0080085 +name: signal recognition particle, chloroplast targeting +namespace: cellular_component +def: "A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast." [PMID:17513500] +is_a: GO:0048500 ! signal recognition particle + +[Term] +id: GO:0080086 +name: stamen filament development +namespace: biological_process +def: "The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen." [PMID:19139039, PO:0009067] +synonym: "filament development" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048443 ! stamen development + +[Term] +id: GO:0080088 +name: spermidine hydroxycinnamate conjugate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spermidine hydroxycinnamate conjugates." [PMID:19077165] +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0080089 +name: sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative." [PMID:19168716] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0080090 +name: regulation of primary metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0044238 ! primary metabolic process + +[Term] +id: GO:0080091 +name: regulation of raffinose metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving raffinose." [PMID:19211694] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +relationship: regulates GO:0033530 ! raffinose metabolic process + +[Term] +id: GO:0080092 +name: regulation of pollen tube growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pollen tube growth." [PMID:19208902] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0051510 ! regulation of unidimensional cell growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009860 ! pollen tube growth + +[Term] +id: GO:0080093 +name: regulation of photorespiration +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of photorespiration. Photorespiration is a light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved." [GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0009853 ! photorespiration + +[Term] +id: GO:0080094 +name: response to trehalose-6-phosphate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus." [PMID:19193861] +synonym: "response to trehalose-6-phosphate stimulus" EXACT [GOC:dos] +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0080095 +name: phosphatidylethanolamine-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine." [PMID:16020547] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0080096 +name: phosphatidate-sterol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate." [PMID:16020547] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0080097 +name: L-tryptophan:pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine." [RHEA:27586] +comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate = 3-(indol-3-yl)pyruvate). +xref: EC:2.6.1.99 +xref: MetaCyc:RXN-10139 +xref: RHEA:27586 +is_a: GO:0070529 ! L-tryptophan aminotransferase activity + +[Term] +id: GO:0080098 +name: L-tyrosine:pyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine." [MetaCyc:RXN3O-4157] +xref: EC:2.6.1.58 +xref: MetaCyc:RXN3O-4157 +is_a: GO:0070547 ! L-tyrosine aminotransferase activity + +[Term] +id: GO:0080099 +name: L-methionine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate." [PMID:18394996] +comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5). +synonym: "L-methionine:alpha-ketoglutarate aminotransferase activity" EXACT [] +is_a: GO:0010326 ! methionine-oxo-acid transaminase activity + +[Term] +id: GO:0080100 +name: L-glutamine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate." [PMID:18394996] +comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50). +synonym: "L-glutamine:alpha-ketoglutarate aminotransferase activity" EXACT [] +xref: EC:2.6.1.50 +is_a: GO:0070548 ! L-glutamine aminotransferase activity + +[Term] +id: GO:0080101 +name: phosphatidyl-N-dimethylethanolamine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine." [EC:2.1.1.71, PMID:19366698] +xref: EC:2.1.1.71 +xref: KEGG_REACTION:R01320 +xref: MetaCyc:RXN4FS-2 +xref: RHEA:32739 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0080102 +name: 3-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +xref: MetaCyc:RXN-2221 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080103 +name: 4-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080104 +name: 5-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080105 +name: 6-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080106 +name: 7-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080107 +name: 8-methylthiopropyl glucosinolate S-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate." [PMID:18799661] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0080108 +name: S-alkylthiohydroximate lyase activity +namespace: molecular_function +def: "Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate." [PMID:14871316] +synonym: "S-alkylthiohydroximate C-S lyase activity" NARROW [] +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0080109 +name: indole-3-acetonitrile nitrile hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide." [EC:4.2.1.84, MetaCyc:RXN-7567, PMID:11607511, PMID:12430025] +xref: EC:4.2.1.84 +xref: KEGG_REACTION:R04020 +xref: MetaCyc:RXN-7567 +is_a: GO:0018822 ! nitrile hydratase activity + +[Term] +id: GO:0080110 +name: sporopollenin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer." [PMID:19218397] +synonym: "sporopollenin biosynthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +relationship: part_of GO:0010584 ! pollen exine formation + +[Term] +id: GO:0080111 +name: DNA demethylation +namespace: biological_process +def: "The removal of a methyl group from one or more nucleotides within an DNA molecule." [PMID:17208187] +is_a: GO:0035510 ! DNA dealkylation +is_a: GO:0044728 ! DNA methylation or demethylation +is_a: GO:0070988 ! demethylation + +[Term] +id: GO:0080112 +name: seed growth +namespace: biological_process +def: "The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo." [GOC:dhl, PO:0009010] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0080113 +name: regulation of seed growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth of the seed of an plant." [PMID:19141706] +synonym: "regulation of seed size" EXACT [] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0080112 ! seed growth + +[Term] +id: GO:0080114 +name: positive regulation of glycine hydroxymethyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1, PMID:19223513] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051347 ! positive regulation of transferase activity + +[Term] +id: GO:0080115 +name: myosin XI tail binding +namespace: molecular_function +def: "Binding to the tail region of a myosin XI heavy chain." [PMID:18703495] +is_a: GO:0032029 ! myosin tail binding + +[Term] +id: GO:0080116 +name: glucuronoxylan glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649] +is_a: GO:0015020 ! glucuronosyltransferase activity + +[Term] +id: GO:0080117 +name: secondary growth +namespace: biological_process +def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium." [ISBN:0471245208, PMID:19074290, PO:0005598, PO:0025004] +comment: Occurs in vascular plants, including gymnosperms and most dicotyledons. Commonly supplemented by activity of the cork cambium or phellogen (PO:0005599). Monocotyledons do not have secondary growth, but may undergo primary thickening (GO:0080192) or secondary thickening (GO:0080191), which can give the appearance of secondary growth. Primary and secondary growth can occur simultaneously in the same organism. +synonym: "cambial secondary growth" EXACT [] +is_a: GO:0080190 ! lateral growth + +[Term] +id: GO:0080118 +name: brassinosteroid sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative." [PMID:10409637, PMID:17039368] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0080119 +name: ER body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the formation of ER (endoplasmic reticulum) body. ER body is a compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:18780803, PMID:19147648] +synonym: "endoplasmic reticulum body organization" EXACT [] +synonym: "endoplasmic reticulum body organization and biogenesis" RELATED [GOC:mah] +synonym: "ER body organisation" EXACT [GOC:mah] +synonym: "ER body organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0080120 +name: CAAX-box protein maturation +namespace: biological_process +def: "A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase." [PMID:12039957, PMID:17114793, PMID:18641086] +synonym: "CAAX-box protein processing" RELATED [] +synonym: "farnesylated protein maturation" RELATED [GOC:vw] +is_a: GO:0044267 ! cellular protein metabolic process +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0080121 +name: AMP transport +namespace: biological_process +def: "The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18923018] +synonym: "adenosine monophosphate transport" EXACT [] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport + +[Term] +id: GO:0080122 +name: AMP transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other." [PMID:18923018] +synonym: "adenosine monophosphate transmembrane transporter activity" EXACT [] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity + +[Term] +id: GO:0080123 +name: jasmonate-amino synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate)." [PMID:15258265, PMID:17291501] +synonym: "ja-amino synthetase activity" EXACT [] +synonym: "jasmonate-amido synthetase activity" EXACT [] +synonym: "jasmonate-amino acid conjugate synthetase activity" EXACT [] +synonym: "jasmonate-amino acid synthetase activity" EXACT [] +synonym: "jasmonate:amino acid synthetase activity" EXACT [] +synonym: "jasmonic acid-amino synthetase activity" EXACT [] +synonym: "jasmonyl-amino synthetase activity" EXACT [] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0080124 +name: pheophytinase activity +namespace: molecular_function +def: "Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide." [PMID:19304936] +synonym: "pheophytin pheophorbide hydrolase activity" EXACT [] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0080125 +name: obsolete multicellular structure septum development +namespace: biological_process +def: "OBSOLETE. The process whose specific outcome is the progression of the multicellular structure septum over time, from its formation to the mature structure. The multicellular structure septum is the thin partition or membrane that divides a cavity or a mass of tissue." [GOC:dhl] +comment: This term was made obsolete because it is not a useful grouping term. +is_obsolete: true + +[Term] +id: GO:0080126 +name: ovary septum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)." [PMID:17855426] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:1905328 ! plant septum development +relationship: part_of GO:0035670 ! plant-type ovary development + +[Term] +id: GO:0080127 +name: fruit septum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit." [GOC:dhl, PO:0005008] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009791 ! post-embryonic development +is_a: GO:1905328 ! plant septum development +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:0080128 +name: anther septum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone." [GOC:dhl, PO:0005010] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:1905328 ! plant septum development +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0080129 +name: proteasome core complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [PMID:12401807, PMID:17971041] +synonym: "20S proteasome assembly" EXACT [] +is_a: GO:0043248 ! proteasome assembly + +[Term] +id: GO:0080130 +name: L-phenylalanine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate." [GOC:pmn_curators, PMID:18394996] +comment: This reaction falls within the larger set of reactions associated with EC:2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57). +synonym: "L-phenylalanine:alpha-ketoglutarate aminotransferase activity" EXACT [] +xref: EC:2.6.1.57 +xref: KEGG_REACTION:R00694 +xref: MetaCyc:PHEAMINOTRANS-RXN +xref: MetaCyc:RXN-10814 +xref: RHEA:25152 +is_a: GO:0008793 ! aromatic-amino-acid:2-oxoglutarate aminotransferase activity +is_a: GO:0070546 ! L-phenylalanine aminotransferase activity + +[Term] +id: GO:0080131 +name: hydroxyjasmonate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate." [EC:2.8.2.-, GOC:pmn_curators, MetaCyc:RXN-10451, MetaCyc:RXN-10453, PMID:12637544] +synonym: "11-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10453] +synonym: "11-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10453] +synonym: "11-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10453] +synonym: "12-hydroxyjasmonate sulfotransferase activity" NARROW [MetaCyc:RXN-10451] +synonym: "12-hydroxyjasmonic acid sulfotransferase activity" NARROW [MetaCyc:RXN-10451] +synonym: "12-OHJA sulfotransferase activity" NARROW [MetaCyc:RXN-10451] +synonym: "hydroxyjasmonic acid sulfotransferase activity" EXACT [] +synonym: "OHJA sulfotransferase activity" EXACT [] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0080132 +name: fatty acid alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain." [PMID:19054355] +synonym: "fatty acid 2-hydroxylase" EXACT [] +xref: Reactome:R-HSA-5693761 "FA2H hydroxylates CERA" +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0080133 +name: midchain alkane hydroxylase activity +namespace: molecular_function +def: "Catalysis of the conversion of an alkane to a secondary alcohol." [PMID:17905869] +is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0080134 +name: regulation of response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0006950 ! response to stress + +[Term] +id: GO:0080135 +name: regulation of cellular response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:dhl] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0033554 ! cellular response to stress + +[Term] +id: GO:0080136 +name: priming of cellular response to stress +namespace: biological_process +def: "The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress." [PMID:19318610] +synonym: "priming of response to stress" BROAD [] +synonym: "priming of stress response" BROAD [] +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: part_of GO:0033554 ! cellular response to stress + +[Term] +id: GO:0080139 +name: borate efflux transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane." [PMID:18603465] +synonym: "boron efflux transmembrane transporter activity" RELATED [] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity +is_a: GO:0015562 ! efflux transmembrane transporter activity + +[Term] +id: GO:0080140 +name: regulation of jasmonic acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid." [GOC:dhl] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +relationship: regulates GO:0009694 ! jasmonic acid metabolic process + +[Term] +id: GO:0080141 +name: regulation of jasmonic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid." [GOC:dhl] +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0080140 ! regulation of jasmonic acid metabolic process +relationship: regulates GO:0009695 ! jasmonic acid biosynthetic process + +[Term] +id: GO:0080142 +name: regulation of salicylic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of salicylic acid." [GOC:dhl] +is_a: GO:0010337 ! regulation of salicylic acid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0009697 ! salicylic acid biosynthetic process + +[Term] +id: GO:0080143 +name: regulation of amino acid export +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle." [PMID:20018597] +is_a: GO:1903789 ! regulation of amino acid transmembrane transport +relationship: regulates GO:0032973 ! amino acid export across plasma membrane + +[Term] +id: GO:0080144 +name: amino acid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell." [PMID:19955263] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0080145 +name: cysteine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of cysteine within an organism or cell." [PMID:19955263] +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0080146 +name: L-cysteine desulfhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+." [MetaCyc:LCYSDESULF-RXN, PMID:19955263] +xref: EC:4.4.1.1 +xref: MetaCyc:LCYSDESULF-RXN +xref: Reactome:R-HSA-1614591 "Excess cysteine yields lanthionine and H2S" +xref: Reactome:R-HSA-1614614 "Cysteine is degraded to serine and H2S" +xref: RHEA:24931 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0080147 +name: root hair cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state." [PMID:19675148] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048765 ! root hair cell differentiation + +[Term] +id: GO:0080148 +name: negative regulation of response to water deprivation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [PMID:18835996] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2000070 ! regulation of response to water deprivation +relationship: negatively_regulates GO:0009414 ! response to water deprivation + +[Term] +id: GO:0080149 +name: sucrose induced translational repression +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level." [PMID:19403731] +synonym: "negative regulation of translation in response to sucrose" EXACT [] +is_a: GO:0032055 ! negative regulation of translation in response to stress + +[Term] +id: GO:0080150 +name: S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine." [MetaCyc:RXN-6722, PMID:10852939] +synonym: "S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity" EXACT [] +xref: MetaCyc:RXN-6722 +xref: RHEA:36099 +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:0080151 +name: positive regulation of salicylic acid mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction." [PMID:20181750] +synonym: "positive regulation of salicylic acid mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2000031 ! regulation of salicylic acid mediated signaling pathway +relationship: positively_regulates GO:0009863 ! salicylic acid mediated signaling pathway + +[Term] +id: GO:0080152 +name: regulation of reductive pentose-phosphate cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle." [PMID:17031544] +synonym: "regulation of C3 photosynthesis" NARROW [] +synonym: "regulation of Calvin cycle" NARROW [] +is_a: GO:0010110 ! regulation of photosynthesis, dark reaction +relationship: regulates GO:0019253 ! reductive pentose-phosphate cycle + +[Term] +id: GO:0080153 +name: negative regulation of reductive pentose-phosphate cycle +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle." [PMID:17031544, PMID:20399532] +synonym: "negative regulation of C3 photosynthesis" NARROW [] +synonym: "negative regulation of Calvin cycle" NARROW [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:0080152 ! regulation of reductive pentose-phosphate cycle +is_a: GO:1905156 ! negative regulation of photosynthesis +relationship: negatively_regulates GO:0019253 ! reductive pentose-phosphate cycle + +[Term] +id: GO:0080154 +name: regulation of fertilization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:DHL, PMID:20478994] +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009566 ! fertilization + +[Term] +id: GO:0080155 +name: regulation of double fertilization forming a zygote and endosperm +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:DHL, PMID:20478994] +is_a: GO:0080154 ! regulation of fertilization +relationship: regulates GO:0009567 ! double fertilization forming a zygote and endosperm + +[Term] +id: GO:0080156 +name: mitochondrial mRNA modification +namespace: biological_process +def: "The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [PMID:20566637] +synonym: "mitochondrial mRNA editing" NARROW [] +synonym: "mitochondrial RNA editing" BROAD [] +is_a: GO:0016556 ! mRNA modification +is_a: GO:1900864 ! mitochondrial RNA modification + +[Term] +id: GO:0080157 +name: regulation of plant-type cell wall organization or biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall." [PMID:20530756] +synonym: "regulation of plant-type cell wall organisation or biogenesis" EXACT [GOC:mah] +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: regulates GO:0071669 ! plant-type cell wall organization or biogenesis + +[Term] +id: GO:0080158 +name: obsolete chloroplast ribulose bisphosphate carboxylase complex biogenesis +namespace: biological_process +def: "OBSOLETE. A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a chloroplast ribulose bisphosphate carboxylase (RubisCO) complex. Includes the synthesis of the constituent protein molecules, and those protein modifications that are involved in synthesis or assembly of the complex." [PMID:20561259] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +is_obsolete: true + +[Term] +id: GO:0080159 +name: zygote elongation +namespace: biological_process +def: "The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana." [GOC:tb] +is_a: GO:0009826 ! unidimensional cell growth +is_a: GO:0048598 ! embryonic morphogenesis + +[Term] +id: GO:0080160 +name: selenate transport +namespace: biological_process +def: "The directed movement of selenate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:18761637] +is_a: GO:0015698 ! inorganic anion transport + +[Term] +id: GO:0080161 +name: auxin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth." [PMID:19506555] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0080162 +name: intracellular auxin transport +namespace: biological_process +def: "The directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth." [PMID:19506555] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0060919 ! auxin influx + +[Term] +id: GO:0080163 +name: regulation of protein serine/threonine phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [PMID:19407142] +synonym: "regulation of protein phosphatase type 2c activity" NARROW [] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:0080164 +name: regulation of nitric oxide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:DHL] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:0080165 +name: callose deposition in phloem sieve plate +namespace: biological_process +def: "Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls." [PMID:19470642] +is_a: GO:0052545 ! callose localization + +[Term] +id: GO:0080166 +name: stomium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released." [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048653 ! anther development + +[Term] +id: GO:0080167 +name: response to karrikin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants)." [PMID:20351290] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0080168 +name: abscisic acid transport +namespace: biological_process +def: "The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:20133881] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0046865 ! terpenoid transport + +[Term] +id: GO:0080169 +name: cellular response to boron-containing substance deprivation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances." [PMID:20059736] +synonym: "cellular response to boron deprivation" EXACT [] +synonym: "cellular response to boron starvation" EXACT [] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0062197 ! cellular response to chemical stress +is_a: GO:0080029 ! cellular response to boron-containing substance levels + +[Term] +id: GO:0080170 +name: hydrogen peroxide transmembrane transport +namespace: biological_process +def: "The process in which hydrogen peroxide is transported across a membrane." [GOC:tb] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "hydrogen peroxide membrane transport" EXACT [] +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0080171 +name: lytic vacuole organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole." [PMID:20729380] +synonym: "lytic vacuolar assembly" NARROW [] +synonym: "lytic vacuole biogenesis" RELATED [] +synonym: "lytic vacuole organisation" EXACT [] +synonym: "lytic vacuole organization and biogenesis" RELATED [] +is_a: GO:0007033 ! vacuole organization + +[Term] +id: GO:0080172 +name: petal epidermis patterning +namespace: biological_process +def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis." [GOC:tb] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0080173 +name: male-female gamete recognition during double fertilization forming a zygote and endosperm +namespace: biological_process +def: "The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana." [PMID:21123745] +synonym: "gamete recognition" BROAD [] +synonym: "male-female gamete recognition" EXACT [] +is_a: GO:0009988 ! cell-cell recognition +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0061936 ! fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm + +[Term] +id: GO:0080175 +name: phragmoplast microtubule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells." [PMID:19383896] +synonym: "phragmoplast microtubule cytoskeleton organization" EXACT [] +synonym: "phragmoplast microtubule organisation" EXACT [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization + +[Term] +id: GO:0080176 +name: xyloglucan 1,6-alpha-xylosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus." [PMID:20801759] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0080177 +name: plastoglobule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [PMID:20813909] +synonym: "plastoglobule organisation" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0009658 ! chloroplast organization + +[Term] +id: GO:0080178 +name: 5-carbamoylmethyl uridine residue modification +namespace: biological_process +def: "The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA." [GOC:dph, GOC:tb] +synonym: "5-carbamoylmethyluridine metabolic process" RELATED [] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0080179 +name: 1-methylguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-methylguanosine." [GOC:tb] +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:0080180 +name: 2-methylguanosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-methylguanosine." [GOC:tb] +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:0080181 +name: lateral root branching +namespace: biological_process +def: "Any process involved in the formation of branches in lateral roots." [GOC:tb] +is_a: GO:0001763 ! morphogenesis of a branching structure +relationship: part_of GO:0010102 ! lateral root morphogenesis + +[Term] +id: GO:0080182 +name: histone H3-K4 trimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone." [GOC:BHF, GOC:se, GOC:tb] +is_a: GO:0018023 ! peptidyl-lysine trimethylation +is_a: GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0080183 +name: response to photooxidative stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [DOI:10.1111/j.1399-3054.1994.tb03042.x] +is_a: GO:0006979 ! response to oxidative stress + +[Term] +id: GO:0080184 +name: response to phenylpropanoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a phenylpropanoid stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. A phenylpropanoid is any of secondary metabolites with structures based on a phenylpropane skeleton. The class includes phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules. Phenylpropanoids are also precursors of lignin." [GOC:tb] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0080185 +name: effector-mediated induction of plant hypersensitive response by symbiont +namespace: biological_process +alt_id: GO:0052101 +alt_id: GO:0052286 +alt_id: GO:0052423 +alt_id: GO:0052527 +def: "A symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes)." [PMID:16497589, PMID:22241993, PMID:23411798, PMID:27641772] +synonym: "activation by organism of defense response in host by specific elicitors" BROAD [] +synonym: "activation by organism of host gene-for-gene resistance" EXACT [] +synonym: "activation by organism of host resistance gene-dependent defense response" EXACT [] +synonym: "activation by symbiont of host resistance gene-dependent defense response" EXACT [] +synonym: "activation of HR" NARROW [GOC:pamgo_curators] +synonym: "activation of hypersensitive response" NARROW [GOC:pamgo_curators] +synonym: "avirulence protein" RELATED [] +synonym: "effector-triggered immunity" BROAD [] +synonym: "effector-triggered induction of host innate immune response" RELATED [] +synonym: "effector-triggered induction of plant hypersensitive response by symbiont" RELATED [] +synonym: "effector-triggered necrosis" RELATED [PMID:27641772] +synonym: "ETI triggered of host innate immune response" RELATED [] +synonym: "ETI-triggered of host innate immune response" RELATED [] +synonym: "induction by organism of defense response in host by specific elicitors" BROAD [] +synonym: "induction by organism of host gene-for-gene resistance" EXACT [] +synonym: "induction by organism of pathogen-race/host plant cultivar-specific resistance in host" BROAD [] +synonym: "induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction" BROAD [] +synonym: "induction by symbiont of host resistance gene-dependent defense response" EXACT [] +synonym: "induction of effector-triggered immunity (ETI)" RELATED [] +synonym: "necrotrophic effector" RELATED [] +synonym: "positive regulation by organism of defense response in host by specific elicitors" BROAD [] +synonym: "positive regulation by organism of host gene-for-gene resistance" EXACT [] +synonym: "positive regulation by symbiont of host resistance gene-dependent defense response" RELATED [] +synonym: "positive regulation by symbiont of plant HR" EXACT [GOC:pamgo_curators] +synonym: "positive regulation by symbiont of plant hypersensitive response" EXACT [GOC:pamgo_curators] +xref: Wikipedia:Effector-triggered_immunity +is_a: GO:0034053 ! modulation by symbiont of host defense-related programmed cell death +is_a: GO:0052042 ! positive regulation by symbiont of host programmed cell death +is_a: GO:0052158 ! modulation by symbiont of host resistance gene-dependent defense response +is_a: GO:0052390 ! induction by symbiont of host innate immune response +is_a: GO:0140404 ! effector-mediated modulation of host innate immune response by symbiont + +[Term] +id: GO:0080186 +name: developmental vegetative growth +namespace: biological_process +def: "The increase in size or mass of non-reproductive plant parts." [PO:0007134] +is_a: GO:0048589 ! developmental growth + +[Term] +id: GO:0080187 +name: floral organ senescence +namespace: biological_process +def: "An organ senescence that has as a participant a floral organ." [PMID:21689171, PO:0025395] +comment: Includes senescence of petals, sepals, anthers, and any other plant organ that is part of a flower. Floral organ senescence may follow pollination. In some flowers, the organs of the corolla abscise before they senesce. +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0090693 ! plant organ senescence +relationship: part_of GO:0048437 ! floral organ development + +[Term] +id: GO:0080188 +name: gene silencing by RNA-directed DNA methylation +namespace: biological_process +def: "A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism." [PMID:21420348] +comment: This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase. +synonym: "RdDM" EXACT [] +synonym: "RNA-directed DNA methylation" RELATED [] +is_a: GO:0006346 ! DNA methylation-dependent heterochromatin assembly +is_a: GO:0140458 ! pre-transcriptional gene silencing by RNA + +[Term] +id: GO:0080189 +name: primary growth +namespace: biological_process +def: "Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed." [ISBN:0471245208] +comment: Has its inception in the apical meristems (PO:0020144) and continues in their derivative meristems - protoderm (PO:0006210) and procambium (PO:0025275) - even in older tissues. Primary and secondary growth can occur simultaneously in the same organism. +is_a: GO:0032501 ! multicellular organismal process +is_a: GO:0040007 ! growth + +[Term] +id: GO:0080190 +name: lateral growth +namespace: biological_process +def: "Growth of a plant axis (shoot axis or root) that originates from a lateral meristem." [PO:0020145] +comment: Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons. +is_a: GO:0040007 ! growth + +[Term] +id: GO:0080191 +name: secondary thickening +namespace: biological_process +def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem." [JSTOR:4354165, PO:0025004, PO:0025414] +comment: Occurs in shoot axes in some monocotyledons such as Dracaena, and rarely in roots of monocotyledons. Distinct from primary thickening, because it is distant from and generally discontinuous with the apical meristem. +is_a: GO:0080190 ! lateral growth + +[Term] +id: GO:0080192 +name: primary thickening +namespace: biological_process +def: "Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem." [ISBN:0471245208, JSTOR:4354165, PO:0005039, PO:0025004] +comment: Occurs in shoot axes and rarely in roots in many monocotyledons. +is_a: GO:0080190 ! lateral growth + +[Term] +id: GO:0080193 +name: diffuse secondary thickening +namespace: biological_process +def: "Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem." [GOC:dhl] +comment: Occurs in the stems (PO:0009047) of some Arecaceae (palms). +is_a: GO:0080190 ! lateral growth + +[Term] +id: GO:0085000 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type V secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type V secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085001 +name: formation of stylet for nutrient acquisition +namespace: biological_process +def: "The assembly of a stylet, a hollow protrusible spear-like symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "formation by symbiont of stylet for nutrient acquisition from host" RELATED [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition + +[Term] +id: GO:0085002 +name: obsolete interaction with host mediated by secreted substance released by symbiont from symbiotic structure +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a symbiont secreted substance released by specialized structures generated in either organisms as a result of the symbiotic interaction. The term host is used for the larger (macro) of the two members of a symbiosis." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085003 +name: obsolete interaction with host via secreted substance released from stylet +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the stylet, a hollow protrusible spear-like structure in the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085004 +name: obsolete interaction with host via secreted substance released from haustorium +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the haustorium, a projection from a cell or tissue that penetrates the host's cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085005 +name: obsolete interaction with host via secreted substance released from invasive hyphae +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via invasive hyphae. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085006 +name: obsolete interaction with host mediated by symbiont secreted substance released from symbiont-containing vacuole +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via a symbiont-containing vacuole, a specialized sac within the host in which the symbiont resides. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with host mediated by symbiont secreted substance released from parasitophorous vacuole" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085007 +name: obsolete interaction with host via secreted substance released from rhoptry +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the rhoptry, a large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secreaton system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085008 +name: obsolete interaction with host via secreted substance released from microneme +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via the microneme, a small, elongated secretory organelle that forms part of the apical complex of an apicomplexan parasite. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was deprecated because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085009 +name: obsolete interaction with host mediated by symbiont secreted substance released from Maurer's cleft +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance released by the other (symbiont) organism via Maurer's cleft. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with host mediated by symbiont secreted substance released from Maurers cleft" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085010 +name: obsolete interaction with host mediated by secreted substance entering host via endocytosis +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a secreted substance from the symbiont entering host cells via endocytosis of the substance. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085011 +name: obsolete interaction with host via protein secreted by Sec complex +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Sec complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with host via protein secreted by Sec secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085012 +name: obsolete interaction with host via protein secreted by Tat complex +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a Tat complex. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "interaction with host via protein secreted by Tat secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085013 +name: obsolete interaction with host via protein secreted by type VII secretion system +namespace: biological_process +def: "OBSOLETE. An interaction with the host organism mediated by a substance secreted by the symbiont organism by a type VII secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085014 +name: dormancy entry of symbiont in host +namespace: biological_process +def: "Entry into a dormant state of the symbiont within the host organism." [GOC:jl] +is_a: GO:0022611 ! dormancy process +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0085015 +name: dormancy maintenance of symbiont in host +namespace: biological_process +def: "Any process in which a dormant state is maintained by the symbiont within the host organism." [GOC:jl] +synonym: "non-replicating persistence" EXACT [] +synonym: "NRP" EXACT [] +is_a: GO:0022611 ! dormancy process +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0085016 +name: dormancy exit of symbiont in host +namespace: biological_process +def: "Exit from dormant state, also known as resuscitation, of the symbiont within the host organism." [GOC:jl] +synonym: "resuscitation of symbiont" EXACT [] +is_a: GO:0022611 ! dormancy process +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0085017 +name: entry into host cell by a symbiont-containing vacuole +namespace: biological_process +alt_id: GO:0052370 +def: "The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole." [GOC:jl, PMID:18665841, PMID:8690024, PMID:9580555] +synonym: "symbiont entry into host cell forming a parasitophorous vacuole" EXACT [] +synonym: "symbiont entry into host cell forming a pathogen-containing vacuole" EXACT [] +synonym: "symbiont entry into host cell forming a symbiont-containing vacuole" RELATED [] +is_a: GO:0044409 ! entry into host + +[Term] +id: GO:0085018 +name: obsolete maintenance of symbiont-containing vacuole by host +namespace: biological_process +def: "OBSOLETE. The process in which a host organism maintains the structure and function of a symbiont-containing vacuole. The symbiont-containing vacuole is a membrane-bounded vacuole within a host cell in which a symbiont organism resides, and can serve to reduce pathogenicity of invading symbionts by restricting them to the vacuolar compartment." [GOC:jl, GOC:yaf, PMID:18665841] +comment: This term has been obsoleted because there is no evidence that this process exists. +synonym: "maintenance of parasitophorous vacuole" EXACT [] +synonym: "maintenance of pathogen-containing vacuole" EXACT [] +synonym: "maintenance of vacuolar integrity during bacterial infection" NARROW [] +is_obsolete: true + +[Term] +id: GO:0085019 +name: formation of tubovesicular network for nutrient acquisition +namespace: biological_process +def: "The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "formation by symbiont of a tubovesicular network for nutrient acquisition from host" RELATED [] +synonym: "formation of a symbiont- induced tubovesicular network for nutrient acquisition from host" EXACT [] +is_a: GO:0052093 ! formation of specialized structure for nutrient acquisition + +[Term] +id: GO:0085020 +name: protein K6-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair." [GOC:sp] +synonym: "protein K6-linked polyubiquitination" EXACT [GOC:mah] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0085021 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type I secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type I secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085022 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VI secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VI secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085023 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by type VII secretion system +namespace: biological_process +def: "OBSOLETE. The process in which an organism effects a change in the structure or function of its host organism, mediated by a substance secreted by a type VII secretion system in the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +is_obsolete: true + +[Term] +id: GO:0085024 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Sec complex +namespace: biological_process +def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Sec complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Sec secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085025 +name: obsolete modification by symbiont of host morphology or physiology via protein secreted by Tat complex +namespace: biological_process +def: "OBSOLETE. The process in which an organism (symbiont) effects a change in the structure or function of its host organism, mediated by a substance secreted by the Tat complex in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +comment: This term was obsoleted because it conflated the process in which a gene product is involved with the secretion system by which it reaches its target. +synonym: "modification by symbiont of host morphology or physiology via protein secreted by the Tat secretion system" EXACT [] +is_obsolete: true + +[Term] +id: GO:0085026 +name: tubovesicular membrane network +namespace: cellular_component +def: "A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains." [GOC:pamgo_curators] +synonym: "TVM network" EXACT [] +synonym: "TVN" EXACT [] +is_a: GO:0033655 ! host cell cytoplasm part +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0085029 +name: extracellular matrix assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the extracellular matrix." [GOC:jl] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0085030 +name: symbiotic process benefiting host +namespace: biological_process +def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism." [GOC:pdt] +synonym: "mutualism" RELATED [] +is_a: GO:0044403 ! biological process involved in symbiotic interaction + +[Term] +id: GO:0085032 +name: modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "modulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] +is_a: GO:0043122 ! regulation of I-kappaB kinase/NF-kappaB signaling +is_a: GO:0052027 ! modulation by symbiont of host signal transduction pathway + +[Term] +id: GO:0085033 +name: induction by symbiont of host I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "activation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway" EXACT [] +synonym: "positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway" EXACT [] +synonym: "stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +synonym: "upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +is_a: GO:0043123 ! positive regulation of I-kappaB kinase/NF-kappaB signaling +is_a: GO:0085032 ! modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade + +[Term] +id: GO:0085034 +name: suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators] +synonym: "negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade" EXACT [] +is_a: GO:0043124 ! negative regulation of I-kappaB kinase/NF-kappaB signaling +is_a: GO:0052029 ! suppression by symbiont of host signal transduction pathway + +[Term] +id: GO:0085035 +name: haustorium +namespace: cellular_component +def: "A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane." [GOC:pamgo_curators] +comment: See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037. +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0085036 +name: extrahaustorial matrix +namespace: cellular_component +def: "The space between the symbiont plasma membrane and the extrahaustorial membrane of the host." [GOC:pamgo_curators] +comment: See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005576 ! extracellular region +relationship: part_of GO:0043655 ! host extracellular space + +[Term] +id: GO:0085037 +name: extrahaustorial membrane +namespace: cellular_component +def: "The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane." [GOC:pamgo_curators] +comment: See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036. +is_a: GO:0033644 ! host cell membrane +relationship: part_of GO:0020002 ! host cell plasma membrane + +[Term] +id: GO:0085039 +name: hyphal membrane +namespace: cellular_component +def: "A host-derived membrane surrounding the symbiont hypha during infection." [GOC:pamgo_curators] +synonym: "extra-invasive hyphal membrane" RELATED [] +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0085040 +name: obsolete extra-invasive hyphal space +namespace: cellular_component +def: "OBSOLETE. The space between the symbiont plasma membrane and the extra-invasive hyphal membrane." [GOC:pamgo_curators] +comment: This term was obsoleted because the cellular component represented is not different from 'host cytoplasm'. +is_obsolete: true + +[Term] +id: GO:0085041 +name: arbuscule +namespace: cellular_component +def: "Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange." [GOC:pamgo_curators] +comment: See also: periarbuscular membrane ; GO:0085042. +is_a: GO:0085035 ! haustorium + +[Term] +id: GO:0085042 +name: periarbuscular membrane +namespace: cellular_component +def: "A host-derived membrane surrounding the symbiont arbuscule during symbiosis." [GOC:pamgo_curators] +comment: See also: arbuscule ; GO:0085041. +is_a: GO:0033644 ! host cell membrane + +[Term] +id: GO:0085044 +name: disassembly by symbiont of host cuticle +namespace: biological_process +def: "The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators] +synonym: "catabolism of host cuticle" EXACT [] +synonym: "degradation of host cuticle" RELATED [] +is_a: GO:0052111 ! modification by symbiont of host structure + +[Term] +id: GO:0086001 +name: cardiac muscle cell action potential +namespace: biological_process +def: "An action potential that occurs in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0001508 ! action potential + +[Term] +id: GO:0086002 +name: cardiac muscle cell action potential involved in contraction +namespace: biological_process +def: "An action potential that occurs in a cardiac muscle cell and is involved in its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086001 ! cardiac muscle cell action potential +relationship: part_of GO:0086003 ! cardiac muscle cell contraction + +[Term] +id: GO:0086003 +name: cardiac muscle cell contraction +namespace: biological_process +def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0070252 ! actin-mediated cell contraction +relationship: part_of GO:0060048 ! cardiac muscle contraction + +[Term] +id: GO:0086004 +name: regulation of cardiac muscle cell contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0055117 ! regulation of cardiac muscle contraction +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: regulates GO:0086003 ! cardiac muscle cell contraction + +[Term] +id: GO:0086005 +name: ventricular cardiac muscle cell action potential +namespace: biological_process +def: "An action potential that occurs in a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction + +[Term] +id: GO:0086006 +name: voltage-gated sodium channel activity involved in cardiac muscle cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0005248 ! voltage-gated sodium channel activity + +[Term] +id: GO:0086007 +name: voltage-gated calcium channel activity involved in cardiac muscle cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0086008 +name: voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0086009 +name: membrane repolarization +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0034220 ! ion transmembrane transport +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0086010 +name: membrane depolarization during action potential +namespace: biological_process +def: "The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0051899 ! membrane depolarization +relationship: part_of GO:0001508 ! action potential + +[Term] +id: GO:0086011 +name: membrane repolarization during action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086009 ! membrane repolarization +relationship: part_of GO:0001508 ! action potential + +[Term] +id: GO:0086012 +name: membrane depolarization during cardiac muscle cell action potential +namespace: biological_process +def: "The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086010 ! membrane depolarization during action potential +relationship: part_of GO:0086001 ! cardiac muscle cell action potential + +[Term] +id: GO:0086013 +name: membrane repolarization during cardiac muscle cell action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086011 ! membrane repolarization during action potential +is_a: GO:0099622 ! cardiac muscle cell membrane repolarization +relationship: part_of GO:0086001 ! cardiac muscle cell action potential + +[Term] +id: GO:0086014 +name: atrial cardiac muscle cell action potential +namespace: biological_process +def: "An action potential that occurs in an atrial cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086002 ! cardiac muscle cell action potential involved in contraction +relationship: part_of GO:0086026 ! atrial cardiac muscle cell to AV node cell signaling + +[Term] +id: GO:0086015 +name: SA node cell action potential +namespace: biological_process +def: "An action potential that occurs in a sinoatrial node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "SA node cardiac muscle cell action potential" EXACT [] +synonym: "SAN cardiac muscle cell action potential" EXACT [] +synonym: "sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0086001 ! cardiac muscle cell action potential +relationship: part_of GO:0086018 ! SA node cell to atrial cardiac muscle cell signaling + +[Term] +id: GO:0086016 +name: AV node cell action potential +namespace: biological_process +def: "An action potential that occurs in an atrioventricular node cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0086001 ! cardiac muscle cell action potential +relationship: part_of GO:0086027 ! AV node cell to bundle of His cell signaling + +[Term] +id: GO:0086017 +name: Purkinje myocyte action potential +namespace: biological_process +def: "An action potential that occurs in a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086001 ! cardiac muscle cell action potential +relationship: part_of GO:0086029 ! Purkinje myocyte to ventricular cardiac muscle cell signaling + +[Term] +id: GO:0086018 +name: SA node cell to atrial cardiac muscle cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell signalling" EXACT [] +synonym: "SA node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] +synonym: "SAN cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] +synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling" EXACT [] +synonym: "sinus node cardiomyocyte to atrial cardiomyocyte signalling" NARROW [] +is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction +is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication + +[Term] +id: GO:0086019 +name: cell-cell signaling involved in cardiac conduction +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "cell-cell signalling involved in cardiac conduction" EXACT [GOC:mah] +is_a: GO:0007267 ! cell-cell signaling +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086020 +name: gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "gap junction channel activity involved in SA node cell-atrial cardiomyocyte electrical coupling" EXACT [] +synonym: "gap junction channel activity involved in SAN cell-atrial cardiomyocyte electrical coupling" EXACT [] +synonym: "gap junction channel activity involved in sinoatrial node cell-atrial cardiomyocyte electrical coupling" EXACT [] +synonym: "gap junction channel activity involved in sinus node cell-atrial cardiomyocyte electrical coupling" NARROW [] +is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling + +[Term] +id: GO:0086021 +name: SA node cell to atrial cardiac muscle cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling" EXACT [] +synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] +synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] +synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" EXACT [] +synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling" NARROW [] +is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction +is_a: GO:0086070 ! SA node cell to atrial cardiac muscle cell communication + +[Term] +id: GO:0086022 +name: SA node cell-atrial cardiac muscle cell adhesion involved in cell communication +namespace: biological_process +def: "The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication" EXACT [] +synonym: "SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] +synonym: "SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] +synonym: "sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" EXACT [] +synonym: "sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication" NARROW [] +is_a: GO:0034113 ! heterotypic cell-cell adhesion +is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion +relationship: part_of GO:0086070 ! SA node cell to atrial cardiac muscle cell communication + +[Term] +id: GO:0086023 +name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "A series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "adrenergic receptor signaling pathway involved in heart process" EXACT [] +synonym: "adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:bf] +synonym: "beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:bf] +is_a: GO:0071880 ! adenylate cyclase-activating adrenergic receptor signaling pathway +is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process + +[Term] +id: GO:0086024 +name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate +namespace: biological_process +def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118] +synonym: "activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] +synonym: "adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] +synonym: "adrenergic receptor signaling pathway involved in positive regulation of heart rate" BROAD [] +synonym: "adrenergic receptor signalling pathway involved in positive regulation of heart rate" BROAD [GOC:bf] +synonym: "beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:mtg_cardiac_conduct_nov11] +synonym: "Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:mtg_cardiac_conduct_nov11] +synonym: "If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine +is_a: GO:0140200 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate +relationship: part_of GO:0010460 ! positive regulation of heart rate + +[Term] +id: GO:0086026 +name: atrial cardiac muscle cell to AV node cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrial cardiomyocyte to atrioventricular node cell signaling" EXACT [] +synonym: "atrial cardiomyocyte to AV node cell signaling" EXACT [] +synonym: "atrial cardiomyocyte to AV node cell signalling" EXACT [GOC:mah] +is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction +is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication + +[Term] +id: GO:0086027 +name: AV node cell to bundle of His cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular node to bundle of His cell signaling" EXACT [] +synonym: "AV node cell to bundle of His cell signalling" EXACT [GOC:mah] +is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction +is_a: GO:0086067 ! AV node cell to bundle of His cell communication + +[Term] +id: GO:0086028 +name: bundle of His cell to Purkinje myocyte signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signaling" EXACT [] +synonym: "bundle of His cardiac muscle cell to Purkinje myocyte signalling" EXACT [GOC:mah] +is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction +is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication + +[Term] +id: GO:0086029 +name: Purkinje myocyte to ventricular cardiac muscle cell signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "Purkinje myocyte to ventricular cardiac muscle cell signalling" EXACT [GOC:mah] +is_a: GO:0086019 ! cell-cell signaling involved in cardiac conduction +is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication + +[Term] +id: GO:0086030 +name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation +namespace: biological_process +def: "An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541] +synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [] +synonym: "adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC" RELATED [GOC:mtg_cardiac_conduct_nov11] +synonym: "adrenergic receptor-induced cardiac relaxation" RELATED [PMID:10571541] +synonym: "Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation" EXACT [GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +relationship: part_of GO:0055119 ! relaxation of cardiac muscle + +[Term] +id: GO:0086033 +name: G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate +namespace: biological_process +def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] +synonym: "M2 receptor signalling pathway involved in negative regulation of heart rate" EXACT [] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] +synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate" EXACT [] +is_a: GO:0086093 ! G protein-coupled acetylcholine receptor signaling pathway involved in heart process +relationship: part_of GO:0003063 ! negative regulation of heart rate by acetylcholine + +[Term] +id: GO:0086036 +name: regulation of cardiac muscle cell membrane potential +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0086037 +name: P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0005391 ! P-type sodium:potassium-exchanging transporter activity + +[Term] +id: GO:0086038 +name: calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0005432 ! calcium:sodium antiporter activity + +[Term] +id: GO:0086039 +name: P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential +namespace: molecular_function +def: "A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential" EXACT [] +is_a: GO:0005388 ! P-type calcium transporter activity + +[Term] +id: GO:0086040 +name: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential" EXACT [] +is_a: GO:0015385 ! sodium:proton antiporter activity + +[Term] +id: GO:0086041 +name: voltage-gated potassium channel activity involved in SA node cell action potential depolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated potassium channel activity involved in SAN cell action potential depolarization" EXACT [] +synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization" EXACT [] +synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential depolarization" NARROW [] +is_a: GO:0005249 ! voltage-gated potassium channel activity + +[Term] +id: GO:0086042 +name: cardiac muscle cell-cardiac muscle cell adhesion +namespace: biological_process +def: "The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "cardiomyocyte-cardiomyocyte adhesion" EXACT [] +is_a: GO:0034109 ! homotypic cell-cell adhesion + +[Term] +id: GO:0086043 +name: bundle of His cell action potential +namespace: biological_process +def: "An action potential that occurs in a bundle of His cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0086001 ! cardiac muscle cell action potential +relationship: part_of GO:0086028 ! bundle of His cell to Purkinje myocyte signaling + +[Term] +id: GO:0086044 +name: atrial cardiac muscle cell to AV node cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling" EXACT [] +synonym: "atrial cardiomyocyte to AV node cell communication by electrical coupling" EXACT [] +is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction +is_a: GO:0086066 ! atrial cardiac muscle cell to AV node cell communication + +[Term] +id: GO:0086045 +name: membrane depolarization during AV node cell action potential +namespace: biological_process +def: "The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "membrane depolarization during AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086016 ! AV node cell action potential + +[Term] +id: GO:0086046 +name: membrane depolarization during SA node cell action potential +namespace: biological_process +def: "The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane depolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] +synonym: "membrane depolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] +synonym: "membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086015 ! SA node cell action potential + +[Term] +id: GO:0086047 +name: membrane depolarization during Purkinje myocyte cell action potential +namespace: biological_process +def: "The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086017 ! Purkinje myocyte action potential + +[Term] +id: GO:0086048 +name: membrane depolarization during bundle of His cell action potential +namespace: biological_process +def: "The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane depolarization during bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086043 ! bundle of His cell action potential + +[Term] +id: GO:0086049 +name: membrane repolarization during AV node cell action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "membrane repolarization involved in regulation of AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +relationship: part_of GO:0086016 ! AV node cell action potential + +[Term] +id: GO:0086050 +name: membrane repolarization during bundle of His cell action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane repolarization during bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +relationship: part_of GO:0086043 ! bundle of His cell action potential + +[Term] +id: GO:0086051 +name: membrane repolarization during Purkinje myocyte action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +relationship: part_of GO:0086017 ! Purkinje myocyte action potential + +[Term] +id: GO:0086052 +name: membrane repolarization during SA node cell action potential +namespace: biological_process +def: "The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] +synonym: "membrane repolarization involved in regulation of SA node cardiac muscle cell action potential" EXACT [] +synonym: "membrane repolarization involved in regulation of SAN cardiac muscle cell action potential" EXACT [] +synonym: "membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +relationship: part_of GO:0086015 ! SA node cell action potential + +[Term] +id: GO:0086053 +name: AV node cell to bundle of His cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular node cell to bundle of His cell communication by electrical coupling" EXACT [] +is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction +is_a: GO:0086067 ! AV node cell to bundle of His cell communication + +[Term] +id: GO:0086054 +name: bundle of His cell to Purkinje myocyte communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling" EXACT [] +is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction +is_a: GO:0086069 ! bundle of His cell to Purkinje myocyte communication + +[Term] +id: GO:0086055 +name: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling +namespace: biological_process +def: "The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction +is_a: GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication + +[Term] +id: GO:0086056 +name: voltage-gated calcium channel activity involved in AV node cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086057 +name: voltage-gated calcium channel activity involved in bundle of His cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086058 +name: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086059 +name: voltage-gated calcium channel activity involved SA node cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0086007 ! voltage-gated calcium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086060 +name: voltage-gated sodium channel activity involved in AV node cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086061 +name: voltage-gated sodium channel activity involved in bundle of His cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086062 +name: voltage-gated sodium channel activity involved in Purkinje myocyte action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086063 +name: voltage-gated sodium channel activity involved in SA node cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0086006 ! voltage-gated sodium channel activity involved in cardiac muscle cell action potential + +[Term] +id: GO:0086064 +name: cell communication by electrical coupling involved in cardiac conduction +namespace: biological_process +def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0010644 ! cell communication by electrical coupling +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086065 +name: cell communication involved in cardiac conduction +namespace: biological_process +def: "Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0007154 ! cell communication +relationship: part_of GO:0061337 ! cardiac conduction + +[Term] +id: GO:0086066 +name: atrial cardiac muscle cell to AV node cell communication +namespace: biological_process +def: "The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrial cardiomyocyte to atrioventricular node cell communication" EXACT [] +synonym: "atrial cardiomyocyte to AV node cell communication" EXACT [] +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086067 +name: AV node cell to bundle of His cell communication +namespace: biological_process +def: "The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular node cell to bundle of His cell communication" EXACT [] +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086068 +name: Purkinje myocyte to ventricular cardiac muscle cell communication +namespace: biological_process +def: "The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086069 +name: bundle of His cell to Purkinje myocyte communication +namespace: biological_process +def: "The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular junction myocyte to bundle branch myocyte" NARROW [] +synonym: "bundle branch myocyte to Purkinje myocyte communication" NARROW [] +synonym: "bundle of His cardiac muscle cell to Purkinje myocyte communication" EXACT [] +synonym: "bundle of His myocyte to atrioventricular junction myocyte" NARROW [] +synonym: "ventricular conduction system cell to cell communication" EXACT [] +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086070 +name: SA node cell to atrial cardiac muscle cell communication +namespace: biological_process +def: "The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "SA node cardiac muscle cell to atrial cardiac muscle cell communication" EXACT [] +synonym: "SA node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] +synonym: "SAN cardiomyocyte to atrial cardiomyocyte communication" EXACT [] +synonym: "sinoatrial node cardiomyocyte to atrial cardiomyocyte communication" EXACT [] +synonym: "sinus node cardiomyocyte to atrial cardiomyocyte communication" NARROW [] +is_a: GO:0086065 ! cell communication involved in cardiac conduction + +[Term] +id: GO:0086071 +name: atrial cardiac muscle cell-AV node cell adhesion involved in cell communication +namespace: biological_process +def: "The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication" EXACT [] +synonym: "atrial cardiomyocyte-AV node cell adhesion involved in cell communication" EXACT [] +is_a: GO:0034113 ! heterotypic cell-cell adhesion +is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion +relationship: part_of GO:0086066 ! atrial cardiac muscle cell to AV node cell communication + +[Term] +id: GO:0086072 +name: AV node cell-bundle of His cell adhesion involved in cell communication +namespace: biological_process +def: "The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "atrioventricular node cell-bundle of His cell adhesion involved in cell communication" EXACT [] +is_a: GO:0034113 ! heterotypic cell-cell adhesion +is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion +relationship: part_of GO:0086067 ! AV node cell to bundle of His cell communication + +[Term] +id: GO:0086073 +name: bundle of His cell-Purkinje myocyte adhesion involved in cell communication +namespace: biological_process +def: "The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0034113 ! heterotypic cell-cell adhesion +is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion +relationship: part_of GO:0086069 ! bundle of His cell to Purkinje myocyte communication + +[Term] +id: GO:0086074 +name: Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication +namespace: biological_process +def: "The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0034113 ! heterotypic cell-cell adhesion +is_a: GO:0086042 ! cardiac muscle cell-cardiac muscle cell adhesion +relationship: part_of GO:0086068 ! Purkinje myocyte to ventricular cardiac muscle cell communication + +[Term] +id: GO:0086075 +name: gap junction channel activity involved in cardiac conduction electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:1903763 ! gap junction channel activity involved in cell communication by electrical coupling + +[Term] +id: GO:0086076 +name: gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "gap junction channel activity involved in atrial cardiomyocyte-atrioventricular node cell electrical coupling" EXACT [] +synonym: "gap junction channel activity involved in atrial cardiomyocyte-AV node cell electrical coupling" RELATED [] +is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling + +[Term] +id: GO:0086077 +name: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "gap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling" EXACT [] +is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling + +[Term] +id: GO:0086078 +name: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling + +[Term] +id: GO:0086079 +name: gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling +namespace: molecular_function +def: "A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086075 ! gap junction channel activity involved in cardiac conduction electrical coupling + +[Term] +id: GO:0086080 +name: protein binding involved in heterotypic cell-cell adhesion +namespace: molecular_function +def: "Binding to a protein or protein complex contributing to the adhesion of two different types of cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0098632 ! cell-cell adhesion mediator activity + +[Term] +id: GO:0086081 +name: cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication +namespace: molecular_function +def: "Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-atrioventricular node cell communication" EXACT [] +synonym: "cell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication" EXACT [] +is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion + +[Term] +id: GO:0086082 +name: cell adhesive protein binding involved in AV node cell-bundle of His cell communication +namespace: molecular_function +def: "Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "cell adhesive protein binding involved in atrioventricular node cell-bundle of His cell communication" EXACT [] +is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion + +[Term] +id: GO:0086083 +name: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication +namespace: molecular_function +def: "Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion + +[Term] +id: GO:0086084 +name: cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication +namespace: molecular_function +def: "Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion + +[Term] +id: GO:0086085 +name: cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication +namespace: molecular_function +def: "Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "cell adhesive protein binding involved in SA cardiomyocyte-atrial cardiomyocyte communication" EXACT [] +is_a: GO:0086080 ! protein binding involved in heterotypic cell-cell adhesion + +[Term] +id: GO:0086086 +name: voltage-gated potassium channel activity involved in AV node cell action potential repolarization +namespace: molecular_function +def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization" EXACT [] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:0086087 +name: voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:0086088 +name: voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:0086089 +name: voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:0086090 +name: voltage-gated potassium channel activity involved in SA node cell action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "voltage-gated potassium channel activity involved in SAN cell action potential" EXACT [] +synonym: "voltage-gated potassium channel activity involved in sinoatrial node cell action potential" EXACT [] +synonym: "voltage-gated potassium channel activity involved in sinus node cell action potential" NARROW [] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:0086091 +name: regulation of heart rate by cardiac conduction +namespace: biological_process +def: "A cardiac conduction process that modulates the frequency or rate of heart contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0002027 ! regulation of heart rate +is_a: GO:0061337 ! cardiac conduction + +[Term] +id: GO:0086092 +name: regulation of the force of heart contraction by cardiac conduction +namespace: biological_process +def: "A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0002026 ! regulation of the force of heart contraction +is_a: GO:0061337 ! cardiac conduction + +[Term] +id: GO:0086093 +name: G protein-coupled acetylcholine receptor signaling pathway involved in heart process +namespace: biological_process +def: "A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in heart process" EXACT [] +synonym: "G-protein coupled acetylcholine receptor signalling pathway involved in heart process" EXACT [GOC:bf] +synonym: "M2 receptor signaling pathway involved in heart process" NARROW [GOC:mtg_cardiac_conduct_nov11] +synonym: "muscarinic receptor signaling pathway involved in heart process" RELATED [GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway +is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process + +[Term] +id: GO:0086094 +name: positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction +namespace: biological_process +def: "An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21099118] +synonym: "adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation" NARROW [PMID:21099118] +is_a: GO:0140200 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate +relationship: part_of GO:0060452 ! positive regulation of cardiac muscle contraction + +[Term] +id: GO:0086095 +name: positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate +namespace: biological_process +def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, Wikipedia:G_protein-gated_ion_channel] +synonym: "cardiac muscarinic receptor signaling via Gbeta/gamma" RELATED [GOC:mtg_cardiac_conduct_nov11] +synonym: "Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:mtg_cardiac_conduct_nov11] +synonym: "muscarinic receptor signaling pathway involved in activation of IKACH" EXACT [GOC:mtg_cardiac_conduct_nov11] +synonym: "muscarinic receptor signaling pathway involved in ion channel activation" BROAD [GOC:mtg_cardiac_conduct_nov11] +synonym: "positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling" EXACT [] +is_a: GO:0086033 ! G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate +is_a: GO:1900129 ! positive regulation of G-protein activated inward rectifier potassium channel activity + +[Term] +id: GO:0086096 +name: adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "An adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart, where the activated adrenergic receptor transmits the signal by Gi-mediated inhibition of adenylate cyclase activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10571541] +comment: Although Beta1-adrenergic receptors couple exclusively to the Gs protein, Beta2-adrenergic receptors couple to both Gs and Gi proteins. Coupling to Gi proteins may localize the Gs-mediated signaling. +synonym: "cardiac adrenergic receptor signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:bf] +synonym: "G-inhibitory-coupled Beta2AR signaling pathway involved in heart process" EXACT [PMID:17376402] +synonym: "Gi-coupled adrenergic receptor signaling pathway involved in heart process" EXACT [PMID:10571541] +synonym: "Gi-coupled Beta2-AR signaling pathway involved in heart process" EXACT [PMID:10571541] +is_a: GO:0071881 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway +is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process + +[Term] +id: GO:0086097 +name: phospholipase C-activating angiotensin-activated signaling pathway +namespace: biological_process +def: "An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "angiotensin-mediated signaling pathway via activation of phospholipase C" EXACT [GOC:bf] +synonym: "Gq-coupled angiotensin receptor signaling pathway" EXACT [GOC:bf] +synonym: "phospholipase C-activating angiotensin receptor signaling pathway" EXACT [GOC:bf] +synonym: "phospholipase C-activating angiotensin-mediated signaling pathway" RELATED [] +synonym: "PLC-activating angiotensin receptor signaling pathway" EXACT [GOC:bf] +is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway +is_a: GO:0038166 ! angiotensin-activated signaling pathway + +[Term] +id: GO:0086098 +name: angiotensin-activated signaling pathway involved in heart process +namespace: biological_process +def: "An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] +synonym: "angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf] +synonym: "angiotensin receptor signalling pathway involved in heart process" EXACT [GOC:bf] +synonym: "angiotensin-mediated signaling pathway involved in heart process" RELATED [] +is_a: GO:0038166 ! angiotensin-activated signaling pathway +is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process + +[Term] +id: GO:0086099 +name: phospholipase C-activating angiotensin-activated signaling pathway involved in heart process +namespace: biological_process +def: "An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] +synonym: "angiotensin receptor signaling pathway via activation of phospholipase C involved in heart process" EXACT [GOC:bf] +synonym: "cardiac angiotensin receptor signaling pathway via activation of PLC" EXACT [GOC:bf] +synonym: "Gq-coupled angiotensin receptor signaling pathway involved in heart process" EXACT [PMID:17376402] +synonym: "phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process" RELATED [] +synonym: "PLC-activating angiotensin receptor signaling pathway involved in heart process" EXACT [GOC:bf] +is_a: GO:0086097 ! phospholipase C-activating angiotensin-activated signaling pathway +is_a: GO:0086098 ! angiotensin-activated signaling pathway involved in heart process + +[Term] +id: GO:0086100 +name: endothelin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869] +synonym: "endothelin signaling pathway" RELATED [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0086101 +name: endothelin receptor signaling pathway involved in heart process +namespace: biological_process +def: "An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] +synonym: "endothelin receptor signalling pathway involved in heart process" EXACT [GOC:bf] +is_a: GO:0086100 ! endothelin receptor signaling pathway +is_a: GO:0086103 ! G protein-coupled receptor signaling pathway involved in heart process + +[Term] +id: GO:0086102 +name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate +namespace: biological_process +def: "A G protein-coupled acetylcholine receptor signaling pathway that contributes to an decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "AC-inhibiting muscarinic receptor signaling pathway involved in negative regulation of heart rate" RELATED [GOC:bf] +synonym: "adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" EXACT [] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate via inhibition of adenylate cyclase activity" EXACT [GOC:bf] +synonym: "Gi-coupled G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" BROAD [GOC:bf] +synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of funny current" EXACT [GOC:mtg_cardiac_conduct_nov11] +synonym: "muscarinic receptor signalling pathway involved in negative regulation of heart rate by inhibition of If channel" EXACT [GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0007197 ! adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway +is_a: GO:0086033 ! G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate + +[Term] +id: GO:0086103 +name: G protein-coupled receptor signaling pathway involved in heart process +namespace: biological_process +def: "An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:17376402] +synonym: "G-protein coupled receptor signaling pathway involved in heart process" EXACT [GOC:bf] +synonym: "G-protein coupled receptor signalling pathway involved in heart process" EXACT [GOC:bf] +synonym: "GPCR signaling pathway involved in cardiac process" EXACT [GOC:bf] +synonym: "GPCR signaling pathway involved in heart process" EXACT [GOC:bf] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +relationship: part_of GO:0003015 ! heart process + +[Term] +id: GO:0089700 +name: protein kinase D signaling +namespace: biological_process +def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dos, GOC:mah] +synonym: "PKD signal transduction" EXACT [GOC:signaling] +synonym: "PKD signaling cascade" RELATED [GOC:mah] +synonym: "protein kinase D signal transduction" EXACT [GOC:signaling] +synonym: "protein kinase D signaling cascade" RELATED [GOC:signaling] +synonym: "protein kinase D signalling cascade" RELATED [GOC:mah] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:0089701 +name: U2AF complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point." [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565] +synonym: "U2 accessory factor" EXACT [] +synonym: "U2AF" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0089702 +name: undecaprenyl-phosphate glucose phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.31, GOC:dos, GOC:imk] +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0089703 +name: L-aspartate transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0034487 ! vacuolar amino acid transmembrane transport +is_a: GO:0070778 ! L-aspartate transmembrane transport + +[Term] +id: GO:0089704 +name: L-glutamate transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0089705 +name: protein localization to outer membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane." [GOC:dos, PMID:12823819] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0089706 +name: L-ornithine transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:1903352 ! L-ornithine transmembrane transport + +[Term] +id: GO:0089707 +name: L-lysine transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-lysine out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:1903401 ! L-lysine transmembrane transport + +[Term] +id: GO:0089708 +name: L-histidine transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:1902024 ! L-histidine transport +is_a: GO:1990822 ! basic amino acid transmembrane transport + +[Term] +id: GO:0089709 +name: L-histidine transmembrane transport +namespace: biological_process +def: "The directed movement of L-histidine across a membrane." [PMID:21307582] +is_a: GO:0015801 ! aromatic amino acid transport +is_a: GO:0045117 ! azole transmembrane transport +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0089710 +name: endocytic targeting sequence binding +namespace: molecular_function +def: "Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits." [PMID:8918456] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0089713 +name: Cbf1-Met4-Met28 complex +namespace: cellular_component +def: "A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation." [PMID:8665859, PMID:9171357] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0089714 +name: UDP-N-acetyl-D-mannosamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+." [EC:1.1.1.336] +xref: EC:1.1.1.336 +xref: RHEA:25780 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0089715 +name: tRNA m6t6A37 methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine." [PMID:25063302] +comment: This activity is distinct from 'tRNA (adenine-N6-)-methyltransferase activity' (GO:0016430) in that it requires the presence of a threonylcarbamoyl modification. +xref: MetaCyc:RXN0-7114 +is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity + +[Term] +id: GO:0089716 +name: Pip2-Oaf1 complex +namespace: cellular_component +def: "A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins." [PMID:8972187, PMID:9288897] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0089717 +name: spanning component of membrane +namespace: cellular_component +def: "The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:dos] +is_a: GO:0016021 ! integral component of membrane + +[Term] +id: GO:0089718 +name: amino acid import across plasma membrane +namespace: biological_process +alt_id: GO:0043092 +alt_id: GO:0044745 +alt_id: GO:1902837 +def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] +synonym: "amino acid import into cell" EXACT [] +synonym: "amino acid transmembrane import" BROAD [] +synonym: "L-amino acid import" BROAD [] +synonym: "L-amino acid uptake" NARROW [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0043090 ! amino acid import +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0089719 +name: RHG protein domain binding +namespace: molecular_function +def: "Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)." [GOC:dos, GOC:ha] +synonym: "iap binding domain binding" EXACT [] +synonym: "inhibitor of apoptosis binding domain binding" EXACT [] +synonym: "reaper hid grim domain binding" EXACT [] +synonym: "RHG domain binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0089720 +name: caspase binding +namespace: molecular_function +def: "Binding to a caspase family protein." [GOC:dos, GOC:ha] +is_a: GO:0002020 ! protease binding + +[Term] +id: GO:0089721 +name: phosphoenolpyruvate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other." [GOC:dos] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity + +[Term] +id: GO:0089722 +name: phosphoenolpyruvate transmembrane transport +namespace: biological_process +def: "The directed movement of phosphoenolpytuvate across a membrane." [GOC:dos] +is_a: GO:0015714 ! phosphoenolpyruvate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0090001 +name: replication fork arrest at tRNA locus +namespace: biological_process +def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb] +is_a: GO:0043111 ! replication fork arrest + +[Term] +id: GO:0090006 +name: regulation of linear element assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:tb] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0060629 ! regulation of homologous chromosome segregation +relationship: regulates GO:0030999 ! linear element assembly + +[Term] +id: GO:0090007 +name: obsolete regulation of mitotic anaphase +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic anaphase, a cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:tb] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "regulation of mitotic anaphase" EXACT [] +is_obsolete: true + +[Term] +id: GO:0090008 +name: hypoblast development +namespace: biological_process +def: "The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0090009 +name: primitive streak formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0001702 ! gastrulation with mouth forming second +relationship: part_of GO:0009948 ! anterior/posterior axis specification + +[Term] +id: GO:0090010 +name: transforming growth factor beta receptor signaling pathway involved in primitive streak formation +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "TGFbeta signaling pathway involved in primitive streak formation" RELATED [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0090009 ! primitive streak formation + +[Term] +id: GO:0090011 +name: Wnt signaling pathway involved in primitive streak formation +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "Wnt receptor signaling pathway involved in primitive streak formation" EXACT [] +synonym: "Wnt receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in primitive streak formation" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0090009 ! primitive streak formation + +[Term] +id: GO:0090012 +name: negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "negative regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] +is_a: GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway +is_a: GO:0090013 ! regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation +relationship: negatively_regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation + +[Term] +id: GO:0090013 +name: regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "regulation of transforming growth factor beta receptor signalling pathway involved in primitive streak formation" EXACT [GOC:mah] +is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway +relationship: regulates GO:0090010 ! transforming growth factor beta receptor signaling pathway involved in primitive streak formation + +[Term] +id: GO:0090014 +name: leaflet formation +namespace: biological_process +def: "The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0060794 ! leaflet morphogenesis + +[Term] +id: GO:0090015 +name: positive regulation of leaflet formation by auxin mediated signaling pathway +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "positive regulation of leaflet formation by auxin mediated signalling pathway" EXACT [GOC:mah] +is_a: GO:0009734 ! auxin-activated signaling pathway +is_a: GO:0090016 ! regulation of leaflet formation +is_a: GO:1905623 ! positive regulation of leaf development +relationship: positively_regulates GO:0090014 ! leaflet formation + +[Term] +id: GO:0090016 +name: regulation of leaflet formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leaflet formation." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:1901371 ! regulation of leaf morphogenesis +relationship: regulates GO:0090014 ! leaflet formation + +[Term] +id: GO:0090017 +name: anterior neural plate formation +namespace: biological_process +def: "The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021990 ! neural plate formation + +[Term] +id: GO:0090018 +name: posterior neural plate formation +namespace: biological_process +def: "The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0021990 ! neural plate formation + +[Term] +id: GO:0090019 +name: obsolete regulation of transcription involved in anterior neural plate formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the anterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0090017 + +[Term] +id: GO:0090020 +name: obsolete regulation of transcription involved in posterior neural plate formation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter contributing to the formation of the posterior neural plate." [GOC:dph, GOC:sdb_2009, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0090018 + +[Term] +id: GO:0090021 +name: positive regulation of posterior neural plate formation by Wnt signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation." [GOC:dph, GOC:sdb_2009, GOC:tb] +synonym: "positive regulation of posterior neural plate formation by Wnt receptor signaling pathway" EXACT [] +synonym: "positive regulation of posterior neural plate formation by Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of posterior neural plate formation by Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: positively_regulates GO:0090018 ! posterior neural plate formation + +[Term] +id: GO:0090022 +name: regulation of neutrophil chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] +is_a: GO:0071622 ! regulation of granulocyte chemotaxis +is_a: GO:1902622 ! regulation of neutrophil migration +relationship: regulates GO:0030593 ! neutrophil chemotaxis + +[Term] +id: GO:0090023 +name: positive regulation of neutrophil chemotaxis +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] +is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis +is_a: GO:0090022 ! regulation of neutrophil chemotaxis +is_a: GO:1902624 ! positive regulation of neutrophil migration +relationship: positively_regulates GO:0030593 ! neutrophil chemotaxis + +[Term] +id: GO:0090024 +name: negative regulation of neutrophil chemotaxis +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:dph, GOC:tb] +is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis +is_a: GO:0090022 ! regulation of neutrophil chemotaxis +is_a: GO:1902623 ! negative regulation of neutrophil migration +relationship: negatively_regulates GO:0030593 ! neutrophil chemotaxis + +[Term] +id: GO:0090025 +name: regulation of monocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: regulates GO:0002548 ! monocyte chemotaxis + +[Term] +id: GO:0090026 +name: positive regulation of monocyte chemotaxis +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0071677 ! positive regulation of mononuclear cell migration +is_a: GO:0090025 ! regulation of monocyte chemotaxis +relationship: positively_regulates GO:0002548 ! monocyte chemotaxis + +[Term] +id: GO:0090027 +name: negative regulation of monocyte chemotaxis +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of monocyte chemotaxis." [GOC:dph, GOC:tb] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0071676 ! negative regulation of mononuclear cell migration +is_a: GO:0090025 ! regulation of monocyte chemotaxis +relationship: negatively_regulates GO:0002548 ! monocyte chemotaxis + +[Term] +id: GO:0090028 +name: positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +is_a: GO:0060239 ! positive regulation of signal transduction involved in conjugation with cellular fusion +relationship: positively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion + +[Term] +id: GO:0090029 +name: negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] +is_a: GO:0010969 ! regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +is_a: GO:0060240 ! negative regulation of signal transduction involved in conjugation with cellular fusion +relationship: negatively_regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion + +[Term] +id: GO:0090030 +name: regulation of steroid hormone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process + +[Term] +id: GO:0090031 +name: positive regulation of steroid hormone biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process + +[Term] +id: GO:0090032 +name: negative regulation of steroid hormone biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones." [GOC:dph, GOC:tb] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process + +[Term] +id: GO:0090033 +name: positive regulation of filamentous growth +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:tb] +is_a: GO:0010570 ! regulation of filamentous growth +is_a: GO:0045927 ! positive regulation of growth +relationship: positively_regulates GO:0030447 ! filamentous growth + +[Term] +id: GO:0090034 +name: regulation of chaperone-mediated protein complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0051131 ! chaperone-mediated protein complex assembly + +[Term] +id: GO:0090035 +name: positive regulation of chaperone-mediated protein complex assembly +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0090034 ! regulation of chaperone-mediated protein complex assembly +relationship: positively_regulates GO:0051131 ! chaperone-mediated protein complex assembly + +[Term] +id: GO:0090036 +name: regulation of protein kinase C signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] +synonym: "regulation of protein kinase C signalling cascade" RELATED [GOC:mah] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0070528 ! protein kinase C signaling + +[Term] +id: GO:0090037 +name: positive regulation of protein kinase C signaling +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "positive regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] +synonym: "positive regulation of protein kinase C signalling cascade" EXACT [GOC:mah] +is_a: GO:0090036 ! regulation of protein kinase C signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0070528 ! protein kinase C signaling + +[Term] +id: GO:0090038 +name: negative regulation of protein kinase C signaling +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound." [GOC:dph, GOC:tb] +synonym: "negative regulation of protein kinase C signaling cascade" RELATED [GOC:signaling] +synonym: "negative regulation of protein kinase C signalling cascade" RELATED [GOC:mah] +is_a: GO:0090036 ! regulation of protein kinase C signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0070528 ! protein kinase C signaling + +[Term] +id: GO:0090042 +name: tubulin deacetylation +namespace: biological_process +def: "The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0006476 ! protein deacetylation + +[Term] +id: GO:0090043 +name: regulation of tubulin deacetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0090311 ! regulation of protein deacetylation +relationship: regulates GO:0090042 ! tubulin deacetylation + +[Term] +id: GO:0090044 +name: positive regulation of tubulin deacetylation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0090043 ! regulation of tubulin deacetylation +is_a: GO:0090312 ! positive regulation of protein deacetylation +relationship: positively_regulates GO:0090042 ! tubulin deacetylation + +[Term] +id: GO:0090045 +name: positive regulation of deacetylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0150065 ! regulation of deacetylase activity + +[Term] +id: GO:0090046 +name: obsolete regulation of transcription regulator activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] +comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. +synonym: "regulation of transcription regulator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0090047 +name: obsolete positive regulation of transcription regulator activity +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] +comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. +synonym: "positive regulation of transcription regulator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0090048 +name: obsolete negative regulation of transcription regulator activity +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:BHF, GOC:rl] +comment: At the time of obsoletion, under "regulation of molecular function", a term exists for "regulation of sequence-specific DNA-binding transcription factor activity" and the positive and negative child terms, but no more detailed terms exist. In reannotating, please consider if the paper would support annotation to a regulation term for a specific RNA polymerase. Also consider if what you need would be regulation of protein binding transcription factor activity or any of its child terms instead. If so, please consider making a SF item regarding creation of such a term. +synonym: "negative regulation of transcription regulator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0090049 +name: regulation of cell migration involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0043535 ! regulation of blood vessel endothelial cell migration +relationship: regulates GO:0002042 ! cell migration involved in sprouting angiogenesis + +[Term] +id: GO:0090050 +name: positive regulation of cell migration involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0043536 ! positive regulation of blood vessel endothelial cell migration +is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis +relationship: positively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis + +[Term] +id: GO:0090051 +name: negative regulation of cell migration involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] +is_a: GO:0043537 ! negative regulation of blood vessel endothelial cell migration +is_a: GO:0090049 ! regulation of cell migration involved in sprouting angiogenesis +relationship: negatively_regulates GO:0002042 ! cell migration involved in sprouting angiogenesis + +[Term] +id: GO:0090052 +name: regulation of pericentric heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] +synonym: "regulation of chromatin silencing at centromere" EXACT [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0031508 ! pericentric heterochromatin assembly + +[Term] +id: GO:0090053 +name: positive regulation of pericentric heterochromatin assembly +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of chromatin silencing at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:dph, GOC:tb] +synonym: "positive regulation of chromatin silencing at centromere" EXACT [] +is_a: GO:0031453 ! positive regulation of heterochromatin assembly +is_a: GO:0090052 ! regulation of pericentric heterochromatin assembly +relationship: positively_regulates GO:0031508 ! pericentric heterochromatin assembly + +[Term] +id: GO:0090054 +name: regulation of silent mating-type cassette heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] +synonym: "regulation of chromatin silencing at silent mating-type cassette" EXACT [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0030466 ! silent mating-type cassette heterochromatin assembly + +[Term] +id: GO:0090055 +name: positive regulation of silent mating-type cassette heterochromatin assembly +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of chromatin silencing at silent mating-type cassette. Chromatin silencing at silent mating-type cassette is the repression of transcription at silent mating-type loci by altering the structure of chromatin." [GOC:dph, GOC:tb] +synonym: "positive regulation of chromatin silencing at silent mating-type cassette" EXACT [] +is_a: GO:0031453 ! positive regulation of heterochromatin assembly +is_a: GO:0090054 ! regulation of silent mating-type cassette heterochromatin assembly +relationship: positively_regulates GO:0030466 ! silent mating-type cassette heterochromatin assembly + +[Term] +id: GO:0090056 +name: regulation of chlorophyll metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll." [GOC:dph, GOC:tb] +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: regulates GO:0015994 ! chlorophyll metabolic process + +[Term] +id: GO:0090057 +name: root radial pattern formation +namespace: biological_process +def: "The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0009956 ! radial pattern formation +relationship: part_of GO:0048364 ! root development + +[Term] +id: GO:0090058 +name: metaxylem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0010089 ! xylem development + +[Term] +id: GO:0090059 +name: protoxylem development +namespace: biological_process +def: "The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:0010089 ! xylem development + +[Term] +id: GO:0090060 +name: regulation of metaxylem development +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed." [GOC:dph, GOC:sdb_2009, GOC:tb] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0090058 ! metaxylem development + +[Term] +id: GO:0090062 +name: regulation of trehalose metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:dph, GOC:tb] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +relationship: regulates GO:0005991 ! trehalose metabolic process + +[Term] +id: GO:0090063 +name: positive regulation of microtubule nucleation +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] +is_a: GO:0010968 ! regulation of microtubule nucleation +is_a: GO:0031116 ! positive regulation of microtubule polymerization +relationship: positively_regulates GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0090064 +name: activation of microtubule nucleation +namespace: biological_process +def: "Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] +is_a: GO:0090063 ! positive regulation of microtubule nucleation + +[Term] +id: GO:0090065 +name: regulation of production of siRNA involved in RNA interference +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:dph, GOC:mah, GOC:tb] +synonym: "regulation of RNA interference, production of siRNA" EXACT [GOC:mah] +is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA +relationship: regulates GO:0030422 ! production of siRNA involved in RNA interference + +[Term] +id: GO:0090066 +name: regulation of anatomical structure size +namespace: biological_process +def: "Any process that modulates the size of an anatomical structure." [GOC:dph, GOC:tb] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0090067 +name: regulation of thalamus size +namespace: biological_process +def: "Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus." [GOC:dph, GOC:tb] +is_a: GO:0090066 ! regulation of anatomical structure size + +[Term] +id: GO:0090068 +name: positive regulation of cell cycle process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0045787 ! positive regulation of cell cycle +relationship: positively_regulates GO:0022402 ! cell cycle process + +[Term] +id: GO:0090069 +name: regulation of ribosome biogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0090070 +name: positive regulation of ribosome biogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0090069 ! regulation of ribosome biogenesis +relationship: positively_regulates GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0090071 +name: negative regulation of ribosome biogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits." [GOC:dph, GOC:tb] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0090069 ! regulation of ribosome biogenesis +relationship: negatively_regulates GO:0042254 ! ribosome biogenesis + +[Term] +id: GO:0090072 +name: obsolete positive regulation of sodium ion transport via voltage-gated sodium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of sodium ions via the activity of voltage-gated sodium channels." [GOC:dph, GOC:tb] +comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. +synonym: "positive regulation of sodium ion transport via voltage-gated sodium channel activity" EXACT [] +is_obsolete: true +consider: GO:0005248 + +[Term] +id: GO:0090073 +name: positive regulation of protein homodimerization activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:0043496 ! regulation of protein homodimerization activity + +[Term] +id: GO:0090074 +name: negative regulation of protein homodimerization activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:dph, GOC:tb] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:0043496 ! regulation of protein homodimerization activity + +[Term] +id: GO:0090075 +name: relaxation of muscle +namespace: biological_process +def: "A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain." [GOC:BHF, GOC:rl, PMID:19996365] +is_a: GO:0003012 ! muscle system process + +[Term] +id: GO:0090076 +name: relaxation of skeletal muscle +namespace: biological_process +def: "A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases." [GOC:BHF, GOC:rl] +is_a: GO:0090075 ! relaxation of muscle + +[Term] +id: GO:0090077 +name: foam cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0090078 +name: smooth muscle derived foam cell differentiation +namespace: biological_process +def: "The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0090077 ! foam cell differentiation + +[Term] +id: GO:0090079 +name: translation regulator activity, nucleic acid binding +namespace: molecular_function +def: "Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:dph, GOC:tb, GOC:vw] +is_a: GO:0003676 ! nucleic acid binding +is_a: GO:0045182 ! translation regulator activity + +[Term] +id: GO:0090080 +name: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade." [GOC:dph, GOC:tb] +synonym: "positive regulation of MAPKKK cascade by fibroblast growth factor receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0043410 ! positive regulation of MAPK cascade + +[Term] +id: GO:0090081 +name: regulation of heart induction by regulation of canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart] +synonym: "regulation of heart induction by regulation of canonical Wnt receptor signaling pathway" EXACT [] +synonym: "regulation of heart induction by regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of heart induction by regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +is_a: GO:0090381 ! regulation of heart induction +relationship: regulates GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway + +[Term] +id: GO:0090082 +name: positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:mtg_heart, PMID:16860783] +synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway" EXACT [] +synonym: "positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development +is_a: GO:0090081 ! regulation of heart induction by regulation of canonical Wnt signaling pathway +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +is_a: GO:1901321 ! positive regulation of heart induction + +[Term] +id: GO:0090083 +name: regulation of inclusion body assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0070841 ! inclusion body assembly + +[Term] +id: GO:0090084 +name: negative regulation of inclusion body assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0090083 ! regulation of inclusion body assembly +relationship: negatively_regulates GO:0070841 ! inclusion body assembly + +[Term] +id: GO:0090085 +name: regulation of protein deubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0090086 +name: negative regulation of protein deubiquitination +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:0090085 ! regulation of protein deubiquitination +is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal +relationship: negatively_regulates GO:0016579 ! protein deubiquitination + +[Term] +id: GO:0090087 +name: regulation of peptide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015833 ! peptide transport + +[Term] +id: GO:0090088 +name: regulation of oligopeptide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:dph, GOC:tb] +is_a: GO:0090087 ! regulation of peptide transport +relationship: regulates GO:0006857 ! oligopeptide transport + +[Term] +id: GO:0090089 +name: regulation of dipeptide transport +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] +is_a: GO:0090088 ! regulation of oligopeptide transport +relationship: regulates GO:0042938 ! dipeptide transport + +[Term] +id: GO:0090090 +name: negative regulation of canonical Wnt signaling pathway +namespace: biological_process +alt_id: GO:0035414 +def: "Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:dph, GOC:tb] +synonym: "negative regulation of canonical Wnt receptor signaling pathway" EXACT [] +synonym: "negative regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "negative regulation of catenin import into nucleus" NARROW [] +synonym: "negative regulation of catenin protein nuclear translocation" NARROW [GOC:mah] +synonym: "negative regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: negatively_regulates GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:0090091 +name: positive regulation of extracellular matrix disassembly +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:dph, GOC:tb] +is_a: GO:0010715 ! regulation of extracellular matrix disassembly +is_a: GO:1903055 ! positive regulation of extracellular matrix organization +relationship: positively_regulates GO:0022617 ! extracellular matrix disassembly + +[Term] +id: GO:0090092 +name: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] +synonym: "regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0090093 +name: regulation of fungal-type cell wall beta-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells." [GOC:dph, GOC:tb] +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process +is_a: GO:0032995 ! regulation of fungal-type cell wall biogenesis +relationship: regulates GO:0070880 ! fungal-type cell wall beta-glucan biosynthetic process + +[Term] +id: GO:0090094 +name: metanephric cap mesenchymal cell proliferation involved in metanephros development +namespace: biological_process +def: "The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf, PMID:19161241] +is_a: GO:0010463 ! mesenchymal cell proliferation +is_a: GO:0072203 ! cell proliferation involved in metanephros development +relationship: part_of GO:0072186 ! metanephric cap morphogenesis + +[Term] +id: GO:0090095 +name: regulation of metanephric cap mesenchymal cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development +relationship: regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development + +[Term] +id: GO:0090096 +name: positive regulation of metanephric cap mesenchymal cell proliferation +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation +is_a: GO:0090095 ! regulation of metanephric cap mesenchymal cell proliferation +is_a: GO:0090184 ! positive regulation of kidney development +is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development +relationship: positively_regulates GO:0090094 ! metanephric cap mesenchymal cell proliferation involved in metanephros development + +[Term] +id: GO:0090100 +name: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] +synonym: "positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: positively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0090101 +name: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:dph, GOC:tb] +synonym: "negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +relationship: negatively_regulates GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway + +[Term] +id: GO:0090102 +name: cochlea development +namespace: biological_process +def: "The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound." [GOC:dph, GOC:tb] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048839 ! inner ear development + +[Term] +id: GO:0090103 +name: cochlea morphogenesis +namespace: biological_process +def: "The process in which the cochlea is generated and organized." [GOC:dph, GOC:tb] +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0042472 ! inner ear morphogenesis +relationship: part_of GO:0090102 ! cochlea development + +[Term] +id: GO:0090104 +name: pancreatic epsilon cell differentiation +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin." [GOC:dph, GOC:tb] +synonym: "pancreatic E cell differentiation" EXACT [] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0031018 ! endocrine pancreas development + +[Term] +id: GO:0090105 +name: pancreatic E cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure." [GOC:dph, GOC:tb] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation + +[Term] +id: GO:0090106 +name: pancreatic E cell fate commitment +namespace: biological_process +def: "The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell." [GOC:dph, GOC:tb] +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0090104 ! pancreatic epsilon cell differentiation + +[Term] +id: GO:0090107 +name: regulation of high-density lipoprotein particle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:dph, GOC:tb] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0034380 ! high-density lipoprotein particle assembly + +[Term] +id: GO:0090108 +name: positive regulation of high-density lipoprotein particle assembly +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0090107 ! regulation of high-density lipoprotein particle assembly +relationship: positively_regulates GO:0034380 ! high-density lipoprotein particle assembly + +[Term] +id: GO:0090109 +name: regulation of cell-substrate junction assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:dph, GOC:tb] +is_a: GO:0150116 ! regulation of cell-substrate junction organization +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: regulates GO:0007044 ! cell-substrate junction assembly + +[Term] +id: GO:0090110 +name: COPII-coated vesicle cargo loading +namespace: biological_process +def: "The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." [GOC:ascb_2009, GOC:dph, GOC:lb, GOC:tb] +synonym: "cargo loading into COPII vesicle" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "cargo loading into COPII-coated vesicle" EXACT [] +synonym: "cargo selection into COPII-coated vesicle" EXACT [GOC:vw] +synonym: "COPII coat-cargo complex assembly" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0035459 ! vesicle cargo loading +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0090114 ! COPII-coated vesicle budding + +[Term] +id: GO:0090111 +name: regulation of COPII vesicle uncoating +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: regulates GO:0090112 ! COPII vesicle uncoating + +[Term] +id: GO:0090112 +name: COPII vesicle uncoating +namespace: biological_process +def: "The process in which COPII vesicle coat proteins are disassembled, and released." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0072319 ! vesicle uncoating +relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:0090113 +name: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis +namespace: biological_process +def: "The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport + +[Term] +id: GO:0090114 +name: COPII-coated vesicle budding +namespace: biological_process +def: "The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "COPII vesicle budding" RELATED [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +synonym: "ER exit" NARROW [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +synonym: "ER vesicle budding" BROAD [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0006900 ! vesicle budding from membrane +relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:0090115 +name: obsolete C-5 methylation on cytosine involved in chromatin silencing +namespace: biological_process +def: "OBSOLETE. The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule that contributes to chromatin silencing." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0090116 +name: C-5 methylation of cytosine +namespace: biological_process +def: "The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0090117 +name: endosome to lysosome transport of low-density lipoprotein particle +namespace: biological_process +def: "The directed movement of low-density lipoprotein particle from endosomes to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "endosome to lysosome transport of LDL" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0008333 ! endosome to lysosome transport +is_a: GO:0090119 ! vesicle-mediated cholesterol transport + +[Term] +id: GO:0090118 +name: receptor-mediated endocytosis involved in cholesterol transport +namespace: biological_process +def: "A receptor-mediated endocytosis process involved in intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:pr, GOC:tb] +synonym: "receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [] +synonym: "receptor-mediated endocytosis of LDL" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:dph] +synonym: "receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0046907 ! intracellular transport +relationship: part_of GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0090119 +name: vesicle-mediated cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0032367 ! intracellular cholesterol transport + +[Term] +id: GO:0090120 +name: lysosome to ER cholesterol transport +namespace: biological_process +def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum." [GOC:mah] +synonym: "lysosome to endoplasmic reticulum cholesterol transport" EXACT [GOC:mah] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0090119 ! vesicle-mediated cholesterol transport + +[Term] +id: GO:0090121 +name: low-density lipoprotein particle disassembly involved in cholesterol transport +namespace: biological_process +def: "The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090495 ! low-density lipoprotein particle disassembly +relationship: part_of GO:0030301 ! cholesterol transport + +[Term] +id: GO:0090122 +name: cholesterol ester hydrolysis involved in cholesterol transport +namespace: biological_process +def: "The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0008203 ! cholesterol metabolic process +relationship: part_of GO:0090119 ! vesicle-mediated cholesterol transport + +[Term] +id: GO:0090123 +name: lysosomal glycocalyx +namespace: cellular_component +def: "The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes." [GOC:ascb_2009, GOC:dph, GOC:krc, GOC:tb, PMID:10521503, PMID:22809326, PMID:29367433] +is_a: GO:0030112 ! glycocalyx +relationship: part_of GO:0005764 ! lysosome + +[Term] +id: GO:0090124 +name: N-4 methylation of cytosine +namespace: biological_process +def: "The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032776 ! DNA methylation on cytosine + +[Term] +id: GO:0090125 +name: cell-cell adhesion involved in synapse maturation +namespace: biological_process +def: "The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "trans-synaptic adhesion" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0060074 ! synapse maturation + +[Term] +id: GO:0090126 +name: protein-containing complex assembly involved in synapse maturation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "protein complex assembly involved in synapse maturation" RELATED [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0060074 ! synapse maturation + +[Term] +id: GO:0090127 +name: positive regulation of synapse maturation by synaptic transmission +namespace: biological_process +def: "Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007268 ! chemical synaptic transmission +is_a: GO:0090129 ! positive regulation of synapse maturation + +[Term] +id: GO:0090128 +name: regulation of synapse maturation +namespace: biological_process +def: "Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] +subset: goslim_synapse +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0060074 ! synapse maturation + +[Term] +id: GO:0090129 +name: positive regulation of synapse maturation +namespace: biological_process +def: "Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0090128 ! regulation of synapse maturation +relationship: positively_regulates GO:0060074 ! synapse maturation + +[Term] +id: GO:0090130 +name: tissue migration +namespace: biological_process +def: "The process in which the population of cells that make up a tissue undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0090131 +name: mesenchyme migration +namespace: biological_process +def: "The process in which the population of cells that make up a mesenchyme undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090130 ! tissue migration +relationship: part_of GO:0072132 ! mesenchyme morphogenesis + +[Term] +id: GO:0090132 +name: epithelium migration +namespace: biological_process +def: "The process in which the population of cells that make up an epithelium undergo directed movement." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090130 ! tissue migration + +[Term] +id: GO:0090133 +name: mesendoderm migration +namespace: biological_process +def: "The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090132 ! epithelium migration +relationship: part_of GO:0007369 ! gastrulation +relationship: part_of GO:0048382 ! mesendoderm development + +[Term] +id: GO:0090134 +name: cell migration involved in mesendoderm migration +namespace: biological_process +def: "The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0042074 ! cell migration involved in gastrulation +relationship: part_of GO:0090133 ! mesendoderm migration + +[Term] +id: GO:0090135 +name: actin filament branching +namespace: biological_process +def: "The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007015 ! actin filament organization + +[Term] +id: GO:0090136 +name: epithelial cell-cell adhesion +namespace: biological_process +def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0090137 +name: epithelial cell-cell adhesion involved in epithelium migration +namespace: biological_process +def: "The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090136 ! epithelial cell-cell adhesion +relationship: part_of GO:0090132 ! epithelium migration + +[Term] +id: GO:0090138 +name: regulation of actin cytoskeleton organization by cell-cell adhesion +namespace: biological_process +def: "Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of actin cytoskeleton organisation by cell-cell adhesion" EXACT [GOC:mah] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0090139 +name: mitochondrial DNA packaging +namespace: biological_process +def: "Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0036385 ! nucleoid DNA packaging + +[Term] +id: GO:0090140 +name: regulation of mitochondrial fission +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010821 ! regulation of mitochondrion organization +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0000266 ! mitochondrial fission + +[Term] +id: GO:0090141 +name: positive regulation of mitochondrial fission +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "positive regulation of mitochondrial division" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0090140 ! regulation of mitochondrial fission +relationship: positively_regulates GO:0000266 ! mitochondrial fission + +[Term] +id: GO:0090143 +name: nucleoid organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "nucleoid organisation" EXACT [GOC:mah] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0090144 +name: mitochondrial nucleoid organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "mitochondrial nucleoid organisation" EXACT [GOC:mah] +is_a: GO:0090143 ! nucleoid organization + +[Term] +id: GO:0090145 +name: obsolete mitochondrial nucleoid organization involved in mitochondrial fission +namespace: biological_process +def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid that contributes to mitochondrial division." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was obsoleted because it represented a phenotype. +synonym: "mitochondrial nucleoid organisation involved in mitochondrial fission" EXACT [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0000002 +consider: GO:0000266 + +[Term] +id: GO:0090146 +name: obsolete establishment of mitochondrion localization involved in mitochondrial fission +namespace: biological_process +def: "OBSOLETE. The directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was obsoleted because it represented a phenotype. +synonym: "establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] +synonym: "mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0000002 +consider: GO:0000266 + +[Term] +id: GO:0090147 +name: obsolete regulation of establishment of mitochondrion localization involved in mitochondrial fission +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was obsoleted because it represented a phenotype. +synonym: "regulation of establishment of mitochondrion localisation involved in mitochondrial fission" EXACT [GOC:mah] +synonym: "regulation of mitochondrial localization involved in mitochondrial fission" RELATED [GOC:dph, GOC:tb] +is_obsolete: true +consider: GO:0000002 +consider: GO:0000266 + +[Term] +id: GO:0090148 +name: membrane fission +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "membrane scission" EXACT [] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0090149 +name: mitochondrial membrane fission +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "membrane fission involved in mitochondrial fission" EXACT [] +synonym: "mitochondrial membrane scission" EXACT [] +is_a: GO:0090148 ! membrane fission +relationship: part_of GO:0000266 ! mitochondrial fission + +[Term] +id: GO:0090150 +name: establishment of protein localization to membrane +namespace: biological_process +def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] +synonym: "establishment of protein localization in membrane" EXACT [] +is_a: GO:0045184 ! establishment of protein localization +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:0090151 +name: establishment of protein localization to mitochondrial membrane +namespace: biological_process +def: "The directed movement of a protein to a specific location in the mitochondrial membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "establishment of protein localisation in mitochondrial membrane" EXACT [GOC:mah] +synonym: "establishment of protein localization in mitochondrial membrane" EXACT [] +is_a: GO:0007006 ! mitochondrial membrane organization +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0072655 ! establishment of protein localization to mitochondrion +is_a: GO:0090150 ! establishment of protein localization to membrane + +[Term] +id: GO:0090152 +name: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission +namespace: biological_process +def: "The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "establishment of protein localisation in mitochondrial membrane involved in mitochondrial fission" EXACT [GOC:mah] +synonym: "establishment of protein localization in mitochondrial membrane involved in mitochondrial fission" EXACT [] +is_a: GO:0090151 ! establishment of protein localization to mitochondrial membrane +relationship: part_of GO:0000266 ! mitochondrial fission + +[Term] +id: GO:0090153 +name: regulation of sphingolipid biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1905038 ! regulation of membrane lipid metabolic process +relationship: regulates GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0090154 +name: positive regulation of sphingolipid biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process +relationship: positively_regulates GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0090155 +name: negative regulation of sphingolipid biosynthetic process +namespace: biological_process +alt_id: GO:0090157 +def: "Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis" RELATED [] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process +relationship: negatively_regulates GO:0030148 ! sphingolipid biosynthetic process + +[Term] +id: GO:0090156 +name: cellular sphingolipid homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0055082 ! cellular chemical homeostasis +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:0090158 +name: endoplasmic reticulum membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "endoplasmic reticulum membrane organisation" EXACT [GOC:mah] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0007029 ! endoplasmic reticulum organization + +[Term] +id: GO:0090159 +name: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "sphingolipid biosynthesis involved in endoplasmic reticulum membrane organisation" EXACT [GOC:mah] +is_a: GO:0030148 ! sphingolipid biosynthetic process +relationship: part_of GO:0090158 ! endoplasmic reticulum membrane organization + +[Term] +id: GO:0090160 +name: Golgi to lysosome transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0006896 ! Golgi to vacuole transport +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0016482 ! cytosolic transport + +[Term] +id: GO:0090161 +name: Golgi ribbon formation +namespace: biological_process +def: "The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007030 ! Golgi organization + +[Term] +id: GO:0090162 +name: establishment of epithelial cell polarity +namespace: biological_process +def: "The specification and formation of anisotropic intracellular organization of an epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:0090163 +name: establishment of epithelial cell planar polarity +namespace: biological_process +def: "The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090162 ! establishment of epithelial cell polarity + +[Term] +id: GO:0090164 +name: asymmetric Golgi ribbon formation +namespace: biological_process +def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090161 ! Golgi ribbon formation +relationship: part_of GO:0090162 ! establishment of epithelial cell polarity + +[Term] +id: GO:0090165 +name: regulation of secretion by asymmetric Golgi ribbon formation +namespace: biological_process +def: "The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0051046 ! regulation of secretion +is_a: GO:0090164 ! asymmetric Golgi ribbon formation + +[Term] +id: GO:0090166 +name: Golgi disassembly +namespace: biological_process +def: "A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007030 ! Golgi organization +is_a: GO:1903008 ! organelle disassembly +relationship: part_of GO:0048313 ! Golgi inheritance + +[Term] +id: GO:0090167 +name: Golgi distribution to daughter cells +namespace: biological_process +def: "Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007030 ! Golgi organization +is_a: GO:0051645 ! Golgi localization +relationship: part_of GO:0048313 ! Golgi inheritance + +[Term] +id: GO:0090168 +name: Golgi reassembly +namespace: biological_process +def: "The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007030 ! Golgi organization +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0048313 ! Golgi inheritance + +[Term] +id: GO:0090169 +name: regulation of spindle assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of spindle formation" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090224 ! regulation of spindle organization +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0051225 ! spindle assembly + +[Term] +id: GO:0090170 +name: regulation of Golgi inheritance +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:1903358 ! regulation of Golgi organization +relationship: regulates GO:0048313 ! Golgi inheritance + +[Term] +id: GO:0090171 +name: chondrocyte morphogenesis +namespace: biological_process +def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +relationship: part_of GO:0002063 ! chondrocyte development + +[Term] +id: GO:0090172 +name: microtubule cytoskeleton organization involved in homologous chromosome segregation +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "microtubule cytoskeleton organisation involved in homologous chromosome segregation" EXACT [GOC:mah] +synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0090173 +name: regulation of synaptonemal complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007130 ! synaptonemal complex assembly + +[Term] +id: GO:0090174 +name: organelle membrane fusion +namespace: biological_process +def: "The joining of two lipid bilayers to form a single organelle membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0048284 ! organelle fusion +is_a: GO:0061025 ! membrane fusion + +[Term] +id: GO:0090175 +name: regulation of establishment of planar polarity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0090176 +name: microtubule cytoskeleton organization involved in establishment of planar polarity +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "microtubule cytoskeleton organisation involved in establishment of planar polarity" EXACT [GOC:mah] +is_a: GO:0000226 ! microtubule cytoskeleton organization +relationship: part_of GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0090177 +name: establishment of planar polarity involved in neural tube closure +namespace: biological_process +def: "Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0042249 ! establishment of planar polarity of embryonic epithelium +is_a: GO:0048598 ! embryonic morphogenesis +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0090178 +name: regulation of establishment of planar polarity involved in neural tube closure +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090175 ! regulation of establishment of planar polarity +relationship: regulates GO:0090177 ! establishment of planar polarity involved in neural tube closure + +[Term] +id: GO:0090179 +name: planar cell polarity pathway involved in neural tube closure +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure +relationship: part_of GO:0001843 ! neural tube closure + +[Term] +id: GO:0090180 +name: positive regulation of thiamine biosynthetic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine." [GOC:dph, GOC:tb] +synonym: "positive regulation of thiamin biosynthetic process" EXACT [] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046136 ! positive regulation of vitamin metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0070623 ! regulation of thiamine biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0009228 ! thiamine biosynthetic process + +[Term] +id: GO:0090181 +name: regulation of cholesterol metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0008203 ! cholesterol metabolic process + +[Term] +id: GO:0090182 +name: regulation of secretion of lysosomal enzymes +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0033299 ! secretion of lysosomal enzymes + +[Term] +id: GO:0090183 +name: regulation of kidney development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] +synonym: "regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0001822 ! kidney development + +[Term] +id: GO:0090184 +name: positive regulation of kidney development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] +synonym: "positive regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0090183 ! regulation of kidney development +relationship: positively_regulates GO:0001822 ! kidney development + +[Term] +id: GO:0090185 +name: negative regulation of kidney development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:tb, GOC:yaf] +synonym: "negative regulation of nephrogenesis" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0090183 ! regulation of kidney development +relationship: negatively_regulates GO:0001822 ! kidney development + +[Term] +id: GO:0090186 +name: regulation of pancreatic juice secretion +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:dph, GOC:tb] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0030157 ! pancreatic juice secretion + +[Term] +id: GO:0090187 +name: positive regulation of pancreatic juice secretion +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:0090186 ! regulation of pancreatic juice secretion +relationship: positively_regulates GO:0030157 ! pancreatic juice secretion + +[Term] +id: GO:0090188 +name: negative regulation of pancreatic juice secretion +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:0090186 ! regulation of pancreatic juice secretion +relationship: negatively_regulates GO:0030157 ! pancreatic juice secretion + +[Term] +id: GO:0090189 +name: regulation of branching involved in ureteric bud morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:0090183 ! regulation of kidney development +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0090190 +name: positive regulation of branching involved in ureteric bud morphogenesis +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0090191 +name: negative regulation of branching involved in ureteric bud morphogenesis +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0090189 ! regulation of branching involved in ureteric bud morphogenesis +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0001658 ! branching involved in ureteric bud morphogenesis + +[Term] +id: GO:0090192 +name: regulation of glomerulus development +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0090183 ! regulation of kidney development +relationship: regulates GO:0032835 ! glomerulus development + +[Term] +id: GO:0090193 +name: positive regulation of glomerulus development +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0090184 ! positive regulation of kidney development +is_a: GO:0090192 ! regulation of glomerulus development +relationship: positively_regulates GO:0032835 ! glomerulus development + +[Term] +id: GO:0090194 +name: negative regulation of glomerulus development +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0090185 ! negative regulation of kidney development +is_a: GO:0090192 ! regulation of glomerulus development +relationship: negatively_regulates GO:0032835 ! glomerulus development + +[Term] +id: GO:0090199 +name: regulation of release of cytochrome c from mitochondria +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] +comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly regulate this process. +is_a: GO:0010821 ! regulation of mitochondrion organization +relationship: regulates GO:0001836 ! release of cytochrome c from mitochondria + +[Term] +id: GO:0090200 +name: positive regulation of release of cytochrome c from mitochondria +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and positively regulate this process. +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria +relationship: positively_regulates GO:0001836 ! release of cytochrome c from mitochondria + +[Term] +id: GO:0090201 +name: negative regulation of release of cytochrome c from mitochondria +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] +comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process. +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:0090199 ! regulation of release of cytochrome c from mitochondria +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +relationship: negatively_regulates GO:0001836 ! release of cytochrome c from mitochondria + +[Term] +id: GO:0090202 +name: obsolete gene looping +namespace: biological_process +def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose sequentially separated regions of RNA polymerase II-transcribed genes." [GOC:dph, GOC:rb, GOC:tb, PMID:19923429, PMID:19933150] +comment: This term was obsoleted because it was defined like a molecular function. +is_obsolete: true +consider: GO:0140587 + +[Term] +id: GO:0090203 +name: obsolete transcriptional activation by promoter-terminator looping +namespace: biological_process +def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes and activate transcription from an RNA polymerase II promoter." [GOC:dph, GOC:rb, GOC:tb] +comment: This term was obsoleted because it was defined like a molecular function. +synonym: "transcriptional activation by memory gene loops" RELATED [GOC:dph, GOC:rb, GOC:tb] +is_obsolete: true +consider: GO:0045893 + +[Term] +id: GO:0090204 +name: protein localization to nuclear pore +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a nuclear pore." [GOC:dph, GOC:rb, GOC:tb] +synonym: "protein localisation to nuclear pore" EXACT [GOC:mah] +is_a: GO:0090435 ! protein localization to nuclear envelope + +[Term] +id: GO:0090205 +name: positive regulation of cholesterol metabolic process +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:0090181 ! regulation of cholesterol metabolic process +relationship: positively_regulates GO:0008203 ! cholesterol metabolic process + +[Term] +id: GO:0090206 +name: negative regulation of cholesterol metabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:0090181 ! regulation of cholesterol metabolic process +relationship: negatively_regulates GO:0008203 ! cholesterol metabolic process + +[Term] +id: GO:0090207 +name: regulation of triglyceride metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006641 ! triglyceride metabolic process + +[Term] +id: GO:0090208 +name: positive regulation of triglyceride metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0090207 ! regulation of triglyceride metabolic process +relationship: positively_regulates GO:0006641 ! triglyceride metabolic process + +[Term] +id: GO:0090209 +name: negative regulation of triglyceride metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0090207 ! regulation of triglyceride metabolic process +relationship: negatively_regulates GO:0006641 ! triglyceride metabolic process + +[Term] +id: GO:0090210 +name: regulation of establishment of blood-brain barrier +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] +synonym: "regulation of establishment of BBB" EXACT [PMID:20080302] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0060856 ! establishment of blood-brain barrier + +[Term] +id: GO:0090211 +name: positive regulation of establishment of blood-brain barrier +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:BHF, GOC:dph, GOC:tb] +synonym: "positive regulation of establishment of BBB" EXACT [PMID:20080302] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0090210 ! regulation of establishment of blood-brain barrier +relationship: positively_regulates GO:0060856 ! establishment of blood-brain barrier + +[Term] +id: GO:0090212 +name: negative regulation of establishment of blood-brain barrier +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain." [GOC:dph, GOC:tb] +synonym: "negative regulation of establishment of BBB" EXACT [PMID:20080302] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0090210 ! regulation of establishment of blood-brain barrier +relationship: negatively_regulates GO:0060856 ! establishment of blood-brain barrier + +[Term] +id: GO:0090213 +name: regulation of radial pattern formation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:tb] +synonym: "regulation of radial pattern specification" NARROW [GOC:tb] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009956 ! radial pattern formation + +[Term] +id: GO:0090214 +name: spongiotrophoblast layer developmental growth +namespace: biological_process +def: "The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state." [GOC:dph, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0048589 ! developmental growth +relationship: part_of GO:0060712 ! spongiotrophoblast layer development + +[Term] +id: GO:0090215 +name: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] +is_a: GO:0043550 ! regulation of lipid kinase activity + +[Term] +id: GO:0090216 +name: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] +is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity +is_a: GO:0090218 ! positive regulation of lipid kinase activity + +[Term] +id: GO:0090217 +name: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GOC:dph, GOC:tb] +is_a: GO:0090215 ! regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity +is_a: GO:0090219 ! negative regulation of lipid kinase activity + +[Term] +id: GO:0090218 +name: positive regulation of lipid kinase activity +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:0043550 ! regulation of lipid kinase activity +is_a: GO:0045834 ! positive regulation of lipid metabolic process + +[Term] +id: GO:0090219 +name: negative regulation of lipid kinase activity +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:dph, GOC:tb] +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:0043550 ! regulation of lipid kinase activity +is_a: GO:0045833 ! negative regulation of lipid metabolic process + +[Term] +id: GO:0090220 +name: chromosome localization to nuclear envelope involved in homologous chromosome segregation +namespace: biological_process +def: "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287] +synonym: "chromosome localisation to nuclear envelope involved in homologous chromosome segregation" EXACT [GOC:mah] +is_a: GO:0051303 ! establishment of chromosome localization +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0045143 ! homologous chromosome segregation + +[Term] +id: GO:0090221 +name: mitotic spindle-templated microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0090222 +name: centrosome-templated microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center + +[Term] +id: GO:0090223 +name: chromatin-templated microtubule nucleation +namespace: biological_process +def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0007020 ! microtubule nucleation + +[Term] +id: GO:0090224 +name: regulation of spindle organization +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of spindle organisation" EXACT [GOC:mah] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization +relationship: regulates GO:0007051 ! spindle organization + +[Term] +id: GO:0090225 +name: regulation of spindle density +namespace: biological_process +def: "Any process that modulates the number of microtubules in a given region of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:0090224 ! regulation of spindle organization + +[Term] +id: GO:0090226 +name: regulation of microtubule nucleation by Ran protein signal transduction +namespace: biological_process +def: "Any series of molecular signals in which a Ran GTPase relays one or more of the signals resulting in the modulation of the rate, frequency or extent of microtubule nucleation." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010968 ! regulation of microtubule nucleation +is_a: GO:0031291 ! Ran protein signal transduction + +[Term] +id: GO:0090227 +name: regulation of red or far-red light signaling pathway +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] +synonym: "regulation of phytochrome signaling pathway" EXACT [GOC:tb] +synonym: "regulation of red or far-red light signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:2000030 ! regulation of response to red or far red light +relationship: regulates GO:0010017 ! red or far-red light signaling pathway + +[Term] +id: GO:0090228 +name: positive regulation of red or far-red light signaling pathway +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] +synonym: "positive regulation of phytochrome signaling pathway" EXACT [GOC:tb] +synonym: "positive regulation of red or far-red light signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0090227 ! regulation of red or far-red light signaling pathway +relationship: positively_regulates GO:0010017 ! red or far-red light signaling pathway + +[Term] +id: GO:0090229 +name: negative regulation of red or far-red light signaling pathway +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light." [GOC:tb] +synonym: "negative regulation of phytochrome signaling pathway" EXACT [GOC:tb] +synonym: "negative regulation of red or far-red light signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0090227 ! regulation of red or far-red light signaling pathway +relationship: negatively_regulates GO:0010017 ! red or far-red light signaling pathway + +[Term] +id: GO:0090230 +name: regulation of centromere complex assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "centromere licensing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0034508 ! centromere complex assembly + +[Term] +id: GO:0090231 +name: regulation of spindle checkpoint +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). +subset: gocheck_do_not_manually_annotate +is_a: GO:1901976 ! regulation of cell cycle checkpoint +relationship: regulates GO:0031577 ! spindle checkpoint signaling + +[Term] +id: GO:0090232 +name: positive regulation of spindle checkpoint +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +subset: gocheck_do_not_manually_annotate +synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090231 ! regulation of spindle checkpoint +is_a: GO:1901978 ! positive regulation of cell cycle checkpoint +relationship: positively_regulates GO:0031577 ! spindle checkpoint signaling + +[Term] +id: GO:0090233 +name: negative regulation of spindle checkpoint +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). +subset: gocheck_do_not_manually_annotate +synonym: "spindle checkpoint silencing" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090231 ! regulation of spindle checkpoint +is_a: GO:1901977 ! negative regulation of cell cycle checkpoint +relationship: negatively_regulates GO:0031577 ! spindle checkpoint signaling + +[Term] +id: GO:0090234 +name: regulation of kinetochore assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of chromosome-kinetochore attachment" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090230 ! regulation of centromere complex assembly +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0051382 ! kinetochore assembly + +[Term] +id: GO:0090235 +name: regulation of metaphase plate congression +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0051310 ! metaphase plate congression + +[Term] +id: GO:0090236 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in somitogenesis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [GOC:ascb_2009, GOC:dph, GOC:tb] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0001756 +consider: GO:0006357 + +[Term] +id: GO:0090237 +name: regulation of arachidonic acid secretion +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:dph, GOC:tb] +is_a: GO:0032303 ! regulation of icosanoid secretion +relationship: regulates GO:0050482 ! arachidonic acid secretion + +[Term] +id: GO:0090238 +name: positive regulation of arachidonic acid secretion +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0032305 ! positive regulation of icosanoid secretion +is_a: GO:0090237 ! regulation of arachidonic acid secretion +relationship: positively_regulates GO:0050482 ! arachidonic acid secretion + +[Term] +id: GO:0090239 +name: regulation of histone H4 acetylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0090240 +name: positive regulation of histone H4 acetylation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:0090239 ! regulation of histone H4 acetylation +relationship: positively_regulates GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0090241 +name: negative regulation of histone H4 acetylation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group." [GOC:dph, GOC:tb] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:0090239 ! regulation of histone H4 acetylation +relationship: negatively_regulates GO:0043967 ! histone H4 acetylation + +[Term] +id: GO:0090242 +name: retinoic acid receptor signaling pathway involved in somitogenesis +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "retinoic acid receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] +is_a: GO:0048384 ! retinoic acid receptor signaling pathway +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0090243 +name: fibroblast growth factor receptor signaling pathway involved in somitogenesis +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "fibroblast growth factor receptor signalling pathway involved in somitogenesis" EXACT [GOC:mah] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0090244 +name: Wnt signaling pathway involved in somitogenesis +namespace: biological_process +def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "Wnt receptor signaling pathway involved in somitogenesis" EXACT [] +synonym: "Wnt receptor signalling" EXACT [GOC:mah] +synonym: "Wnt-activated signaling pathway involved in somitogenesis" EXACT [GOC:signaling] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0090245 +name: axis elongation involved in somitogenesis +namespace: biological_process +def: "The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0003401 ! axis elongation +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:0090246 +name: convergent extension involved in somitogenesis +namespace: biological_process +def: "The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0060027 ! convergent extension involved in gastrulation +is_a: GO:0060028 ! convergent extension involved in axis elongation +relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis + +[Term] +id: GO:0090248 +name: cell migration involved in somitogenic axis elongation +namespace: biological_process +alt_id: GO:0090247 +def: "Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "cell motility involved in somitogenic axis elongation" BROAD [] +is_a: GO:0016477 ! cell migration +relationship: part_of GO:0090245 ! axis elongation involved in somitogenesis + +[Term] +id: GO:0090249 +name: regulation of cell migration involved in somitogenic axis elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "regulation of cell motility involved in somitogenic axis elongation" BROAD [] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0090248 ! cell migration involved in somitogenic axis elongation + +[Term] +id: GO:0090250 +name: cell-cell adhesion involved in establishment of planar polarity +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0090251 +name: protein localization involved in establishment of planar polarity +namespace: biological_process +def: "Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity." [GOC:ascb_2009, GOC:dph, GOC:tb] +synonym: "protein localisation involved in establishment of planar polarity" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization +relationship: part_of GO:0001736 ! establishment of planar polarity + +[Term] +id: GO:0090252 +name: epithelium migration involved in imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0090132 ! epithelium migration +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0090253 +name: convergent extension involved in imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0009886 ! post-embryonic animal morphogenesis +is_a: GO:0060029 ! convergent extension involved in organogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0090254 +name: cell elongation involved in imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0009826 ! unidimensional cell growth +is_a: GO:0009886 ! post-embryonic animal morphogenesis +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0090255 +name: cell proliferation involved in imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0090256 +name: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis +relationship: regulates GO:0090255 ! cell proliferation involved in imaginal disc-derived wing morphogenesis + +[Term] +id: GO:0090257 +name: regulation of muscle system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system." [GOC:dph, GOC:tb] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0003012 ! muscle system process + +[Term] +id: GO:0090258 +name: negative regulation of mitochondrial fission +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [GOC:sl, GOC:tb] +synonym: "negative regulation of mitochondrial division" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0090140 ! regulation of mitochondrial fission +relationship: negatively_regulates GO:0000266 ! mitochondrial fission + +[Term] +id: GO:0090259 +name: regulation of retinal ganglion cell axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0031290 ! retinal ganglion cell axon guidance + +[Term] +id: GO:0090260 +name: negative regulation of retinal ganglion cell axon guidance +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:tb, GOC:yaf] +comment: Note that growth cone collapse has been observed only in assays performed in vitro. +synonym: "axon growth cone collapse" RELATED [] +is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance +is_a: GO:1902668 ! negative regulation of axon guidance +relationship: negatively_regulates GO:0031290 ! retinal ganglion cell axon guidance + +[Term] +id: GO:0090261 +name: positive regulation of inclusion body assembly +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body." [GOC:tb] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0090083 ! regulation of inclusion body assembly +relationship: positively_regulates GO:0070841 ! inclusion body assembly + +[Term] +id: GO:0090262 +name: regulation of transcription-coupled nucleotide-excision repair +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [GOC:tb] +is_a: GO:2000819 ! regulation of nucleotide-excision repair +relationship: regulates GO:0006283 ! transcription-coupled nucleotide-excision repair + +[Term] +id: GO:0090263 +name: positive regulation of canonical Wnt signaling pathway +namespace: biological_process +alt_id: GO:0035413 +def: "Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes." [GOC:tb] +synonym: "positive regulation of canonical Wnt receptor signaling pathway" EXACT [] +synonym: "positive regulation of canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "positive regulation of catenin import into nucleus" NARROW [] +synonym: "positive regulation of catenin protein nuclear translocation" NARROW [GOC:mah] +synonym: "positive regulation of Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:mtg_signal] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: positively_regulates GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:0090264 +name: regulation of immune complex clearance by monocytes and macrophages +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:tb] +is_a: GO:0002697 ! regulation of immune effector process +relationship: regulates GO:0002436 ! immune complex clearance by monocytes and macrophages + +[Term] +id: GO:0090265 +name: positive regulation of immune complex clearance by monocytes and macrophages +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages." [GOC:BHF] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0090264 ! regulation of immune complex clearance by monocytes and macrophages +relationship: positively_regulates GO:0002436 ! immune complex clearance by monocytes and macrophages + +[Term] +id: GO:0090266 +name: regulation of mitotic cell cycle spindle assembly checkpoint +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle] +is_a: GO:0007088 ! regulation of mitotic nuclear division +is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +is_a: GO:1903504 ! regulation of mitotic spindle checkpoint +relationship: regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling + +[Term] +id: GO:0090267 +name: positive regulation of mitotic cell cycle spindle assembly checkpoint +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0090232 ! positive regulation of spindle checkpoint +is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint +relationship: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling + +[Term] +id: GO:0090268 +name: activation of mitotic cell cycle spindle assembly checkpoint +namespace: biological_process +def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw] +is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint + +[Term] +id: GO:0090269 +name: fibroblast growth factor production +namespace: biological_process +def: "The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +subset: gocheck_do_not_annotate +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0090270 +name: regulation of fibroblast growth factor production +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0090269 ! fibroblast growth factor production + +[Term] +id: GO:0090271 +name: positive regulation of fibroblast growth factor production +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0090270 ! regulation of fibroblast growth factor production +relationship: positively_regulates GO:0090269 ! fibroblast growth factor production + +[Term] +id: GO:0090272 +name: negative regulation of fibroblast growth factor production +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0090270 ! regulation of fibroblast growth factor production +relationship: negatively_regulates GO:0090269 ! fibroblast growth factor production + +[Term] +id: GO:0090273 +name: regulation of somatostatin secretion +namespace: biological_process +def: "Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0070253 ! somatostatin secretion + +[Term] +id: GO:0090274 +name: positive regulation of somatostatin secretion +namespace: biological_process +def: "Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] +is_a: GO:0090273 ! regulation of somatostatin secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0070253 ! somatostatin secretion + +[Term] +id: GO:0090275 +name: negative regulation of somatostatin secretion +namespace: biological_process +def: "Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." [GOC:BHF] +is_a: GO:0090273 ! regulation of somatostatin secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0070253 ! somatostatin secretion + +[Term] +id: GO:0090276 +name: regulation of peptide hormone secretion +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] +is_a: GO:0002791 ! regulation of peptide secretion +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0090277 +name: positive regulation of peptide hormone secretion +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] +is_a: GO:0002793 ! positive regulation of peptide secretion +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: positively_regulates GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0090278 +name: negative regulation of peptide hormone secretion +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules." [GOC:tb] +is_a: GO:0002792 ! negative regulation of peptide secretion +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: negatively_regulates GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0090279 +name: regulation of calcium ion import +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] +synonym: "regulation of transmembrane calcium influx" RELATED [GOC:tb] +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: regulates GO:0070509 ! calcium ion import + +[Term] +id: GO:0090280 +name: positive regulation of calcium ion import +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] +synonym: "positive regulation of transmembrane calcium influx" RELATED [GOC:tb] +is_a: GO:0051928 ! positive regulation of calcium ion transport +is_a: GO:0090279 ! regulation of calcium ion import +relationship: positively_regulates GO:0070509 ! calcium ion import + +[Term] +id: GO:0090281 +name: negative regulation of calcium ion import +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle." [GOC:BHF] +synonym: "negative regulation of transmembrane calcium influx" RELATED [GOC:tb] +is_a: GO:0051926 ! negative regulation of calcium ion transport +is_a: GO:0090279 ! regulation of calcium ion import +relationship: negatively_regulates GO:0070509 ! calcium ion import + +[Term] +id: GO:0090282 +name: positive regulation of transcription involved in G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:rn, PMID:10747051, PMID:10894548, PMID:10899128, PMID:10959837] +synonym: "activation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] +synonym: "activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] +synonym: "activation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn] +synonym: "positive regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] +synonym: "positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle" EXACT [GOC:rn] +synonym: "up-regulation of G2/M-specific transcription in the mitotic cell cycle" EXACT [GOC:rn] +synonym: "up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" EXACT [GOC:rn] +synonym: "up-regulation of transcription involved in G2/M transition of mitotic cell cycle" EXACT [GOC:rn] +is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0090283 +name: regulation of protein glycosylation in Golgi +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] +synonym: "regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +is_a: GO:0060049 ! regulation of protein glycosylation +relationship: regulates GO:0033578 ! protein glycosylation in Golgi + +[Term] +id: GO:0090284 +name: positive regulation of protein glycosylation in Golgi +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] +synonym: "positive regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +is_a: GO:0060050 ! positive regulation of protein glycosylation +is_a: GO:0090283 ! regulation of protein glycosylation in Golgi +relationship: positively_regulates GO:0033578 ! protein glycosylation in Golgi + +[Term] +id: GO:0090285 +name: negative regulation of protein glycosylation in Golgi +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." [GOC:pr, GOC:tb] +synonym: "negative regulation of protein amino acid glycosylation in Golgi" EXACT [GOC:bf] +is_a: GO:0060051 ! negative regulation of protein glycosylation +is_a: GO:0090283 ! regulation of protein glycosylation in Golgi +relationship: negatively_regulates GO:0033578 ! protein glycosylation in Golgi + +[Term] +id: GO:0090286 +name: obsolete cytoskeletal anchoring at nuclear membrane +namespace: biological_process +def: "OBSOLETE. The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane." [GOC:tb] +comment: This term was obsoleted because it represented a molecular function. +is_obsolete: true +consider: GO:0140444 + +[Term] +id: GO:0090287 +name: regulation of cellular response to growth factor stimulus +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:tb] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071363 ! cellular response to growth factor stimulus + +[Term] +id: GO:0090288 +name: negative regulation of cellular response to growth factor stimulus +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus." [GOC:BHF] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: negatively_regulates GO:0071363 ! cellular response to growth factor stimulus + +[Term] +id: GO:0090289 +name: regulation of osteoclast proliferation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: regulates GO:0002158 ! osteoclast proliferation + +[Term] +id: GO:0090290 +name: positive regulation of osteoclast proliferation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] +is_a: GO:0070665 ! positive regulation of leukocyte proliferation +is_a: GO:0090289 ! regulation of osteoclast proliferation +relationship: positively_regulates GO:0002158 ! osteoclast proliferation + +[Term] +id: GO:0090291 +name: negative regulation of osteoclast proliferation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population." [GOC:tb] +is_a: GO:0070664 ! negative regulation of leukocyte proliferation +is_a: GO:0090289 ! regulation of osteoclast proliferation +relationship: negatively_regulates GO:0002158 ! osteoclast proliferation + +[Term] +id: GO:0090292 +name: nuclear matrix anchoring at nuclear membrane +namespace: biological_process +def: "The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane." [GOC:tb] +synonym: "nucleoskeleton anchoring at nuclear membrane" EXACT [GOC:tb] +is_a: GO:0043578 ! nuclear matrix organization +is_a: GO:0051457 ! maintenance of protein location in nucleus + +[Term] +id: GO:0090293 +name: nitrogen catabolite regulation of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] +synonym: "regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:0031670 ! cellular response to nutrient +relationship: part_of GO:0071417 ! cellular response to organonitrogen compound + +[Term] +id: GO:0090294 +name: nitrogen catabolite activation of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] +synonym: "positive regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:0090293 ! nitrogen catabolite regulation of transcription + +[Term] +id: GO:0090295 +name: nitrogen catabolite repression of transcription +namespace: biological_process +def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:rb, PMID:19104072] +synonym: "negative regulation of transcription by nitrogen catabolites" EXACT [GOC:mah] +synonym: "nitrogen catabolite repression" EXACT [GOC:mah, GOC:rb] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0061984 ! catabolite repression +is_a: GO:0090293 ! nitrogen catabolite regulation of transcription + +[Term] +id: GO:0090296 +name: regulation of mitochondrial DNA replication +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] +synonym: "regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0006264 ! mitochondrial DNA replication + +[Term] +id: GO:0090297 +name: positive regulation of mitochondrial DNA replication +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] +synonym: "positive regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] +is_a: GO:0090296 ! regulation of mitochondrial DNA replication +is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication +relationship: positively_regulates GO:0006264 ! mitochondrial DNA replication + +[Term] +id: GO:0090298 +name: negative regulation of mitochondrial DNA replication +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion." [GOC:tb] +synonym: "negative regulation of mitochondrial DNA synthesis" RELATED [GOC:tb] +is_a: GO:0090296 ! regulation of mitochondrial DNA replication +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0006264 ! mitochondrial DNA replication + +[Term] +id: GO:0090299 +name: regulation of neural crest formation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds." [GOC:tb] +is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0014029 ! neural crest formation + +[Term] +id: GO:0090300 +name: positive regulation of neural crest formation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] +is_a: GO:0010718 ! positive regulation of epithelial to mesenchymal transition +is_a: GO:0090299 ! regulation of neural crest formation +relationship: positively_regulates GO:0014029 ! neural crest formation + +[Term] +id: GO:0090301 +name: negative regulation of neural crest formation +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:tb] +is_a: GO:0010719 ! negative regulation of epithelial to mesenchymal transition +is_a: GO:0090299 ! regulation of neural crest formation +relationship: negatively_regulates GO:0014029 ! neural crest formation + +[Term] +id: GO:0090303 +name: positive regulation of wound healing +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." [GOC:BHF] +is_a: GO:0061041 ! regulation of wound healing +is_a: GO:1903036 ! positive regulation of response to wounding +relationship: positively_regulates GO:0042060 ! wound healing + +[Term] +id: GO:0090304 +name: nucleic acid metabolic process +namespace: biological_process +def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] +is_a: GO:0006139 ! nucleobase-containing compound metabolic process +is_a: GO:0043170 ! macromolecule metabolic process + +[Term] +id: GO:0090305 +name: nucleic acid phosphodiester bond hydrolysis +namespace: biological_process +def: "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] +synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb] +is_a: GO:0090304 ! nucleic acid metabolic process + +[Term] +id: GO:0090306 +name: meiotic spindle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] +synonym: "spindle assembly involved in meiosis" EXACT [] +is_a: GO:0000212 ! meiotic spindle organization +is_a: GO:0051225 ! spindle assembly +relationship: part_of GO:0140013 ! meiotic nuclear division + +[Term] +id: GO:0090307 +name: mitotic spindle assembly +namespace: biological_process +def: "Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied." [GOC:tb, GOC:vw] +synonym: "spindle assembly involved in mitosis" EXACT [] +is_a: GO:0007052 ! mitotic spindle organization +is_a: GO:0051225 ! spindle assembly +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0090308 +name: regulation of DNA methylation-dependent heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] +synonym: "regulation of methylation-dependent chromatin silencing" BROAD [] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0006346 ! DNA methylation-dependent heterochromatin assembly + +[Term] +id: GO:0090309 +name: positive regulation of DNA methylation-dependent heterochromatin assembly +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] +synonym: "positive regulation of methylation-dependent chromatin silencing" BROAD [] +is_a: GO:0031453 ! positive regulation of heterochromatin assembly +is_a: GO:0090308 ! regulation of DNA methylation-dependent heterochromatin assembly +relationship: positively_regulates GO:0006346 ! DNA methylation-dependent heterochromatin assembly + +[Term] +id: GO:0090310 +name: negative regulation of DNA methylation-dependent heterochromatin assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:BHF] +synonym: "negative regulation of methylation-dependent chromatin silencing" BROAD [] +is_a: GO:0031452 ! negative regulation of heterochromatin assembly +is_a: GO:0090308 ! regulation of DNA methylation-dependent heterochromatin assembly +relationship: negatively_regulates GO:0006346 ! DNA methylation-dependent heterochromatin assembly + +[Term] +id: GO:0090311 +name: regulation of protein deacetylation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:tb] +synonym: "regulation of protein amino acid deacetylation" EXACT [GOC:bf] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0006476 ! protein deacetylation + +[Term] +id: GO:0090312 +name: positive regulation of protein deacetylation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ecd, PMID:20027304] +synonym: "positive regulation of protein amino acid deacetylation" EXACT [GOC:bf] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0090311 ! regulation of protein deacetylation +relationship: positively_regulates GO:0006476 ! protein deacetylation + +[Term] +id: GO:0090313 +name: regulation of protein targeting to membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] +is_a: GO:1903533 ! regulation of protein targeting +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0006612 ! protein targeting to membrane + +[Term] +id: GO:0090314 +name: positive regulation of protein targeting to membrane +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] +is_a: GO:0090313 ! regulation of protein targeting to membrane +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:0006612 ! protein targeting to membrane + +[Term] +id: GO:0090315 +name: negative regulation of protein targeting to membrane +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:tb] +is_a: GO:0090313 ! regulation of protein targeting to membrane +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:0006612 ! protein targeting to membrane + +[Term] +id: GO:0090316 +name: positive regulation of intracellular protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0051222 ! positive regulation of protein transport +relationship: positively_regulates GO:0006886 ! intracellular protein transport + +[Term] +id: GO:0090317 +name: negative regulation of intracellular protein transport +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells." [GOC:tb] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0051224 ! negative regulation of protein transport +relationship: negatively_regulates GO:0006886 ! intracellular protein transport +relationship: negatively_regulates GO:0034613 ! cellular protein localization + +[Term] +id: GO:0090318 +name: regulation of chylomicron remodeling +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0034371 ! chylomicron remodeling + +[Term] +id: GO:0090319 +name: positive regulation of chylomicron remodeling +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:BHF] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0090318 ! regulation of chylomicron remodeling +relationship: positively_regulates GO:0034371 ! chylomicron remodeling + +[Term] +id: GO:0090320 +name: regulation of chylomicron remnant clearance +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:tb] +is_a: GO:0010984 ! regulation of lipoprotein particle clearance +relationship: regulates GO:0034382 ! chylomicron remnant clearance + +[Term] +id: GO:0090321 +name: positive regulation of chylomicron remnant clearance +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded." [GOC:BHF] +is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance +is_a: GO:0090320 ! regulation of chylomicron remnant clearance +relationship: positively_regulates GO:0034382 ! chylomicron remnant clearance + +[Term] +id: GO:0090322 +name: regulation of superoxide metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:tb] +synonym: "regulation of superoxide metabolism" EXACT [GOC:tb] +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process +relationship: regulates GO:0006801 ! superoxide metabolic process + +[Term] +id: GO:0090323 +name: prostaglandin secretion involved in immune response +namespace: biological_process +def: "The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring." [GOC:dph, GOC:tb] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0002440 ! production of molecular mediator of immune response +is_a: GO:0032310 ! prostaglandin secretion +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0090324 +name: negative regulation of oxidative phosphorylation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:BHF] +is_a: GO:0002082 ! regulation of oxidative phosphorylation +is_a: GO:1901856 ! negative regulation of cellular respiration +is_a: GO:1903579 ! negative regulation of ATP metabolic process +relationship: negatively_regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:0090325 +name: regulation of locomotion involved in locomotory behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0031987 ! locomotion involved in locomotory behavior + +[Term] +id: GO:0090326 +name: positive regulation of locomotion involved in locomotory behavior +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior +relationship: positively_regulates GO:0031987 ! locomotion involved in locomotory behavior + +[Term] +id: GO:0090327 +name: negative regulation of locomotion involved in locomotory behavior +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:dph, GOC:kmv, GOC:tb] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0090325 ! regulation of locomotion involved in locomotory behavior +relationship: negatively_regulates GO:0031987 ! locomotion involved in locomotory behavior + +[Term] +id: GO:0090328 +name: regulation of olfactory learning +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [GOC:dph, GOC:tb] +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0008355 ! olfactory learning + +[Term] +id: GO:0090329 +name: regulation of DNA-dependent DNA replication +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:dph, GOC:tb] +is_a: GO:0006275 ! regulation of DNA replication +relationship: regulates GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:0090330 +name: regulation of platelet aggregation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:dph, GOC:tb] +is_a: GO:0010543 ! regulation of platelet activation +is_a: GO:0034110 ! regulation of homotypic cell-cell adhesion +relationship: regulates GO:0070527 ! platelet aggregation + +[Term] +id: GO:0090331 +name: negative regulation of platelet aggregation +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:BHF] +synonym: "platelet disaggregation" NARROW [GOC:dph, PMID:12871378] +is_a: GO:0010544 ! negative regulation of platelet activation +is_a: GO:0034111 ! negative regulation of homotypic cell-cell adhesion +is_a: GO:0090330 ! regulation of platelet aggregation +relationship: negatively_regulates GO:0070527 ! platelet aggregation + +[Term] +id: GO:0090332 +name: stomatal closure +namespace: biological_process +def: "The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] +is_a: GO:0010118 ! stomatal movement + +[Term] +id: GO:0090333 +name: regulation of stomatal closure +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [GOC:tb] +is_a: GO:0010119 ! regulation of stomatal movement +relationship: regulates GO:0090332 ! stomatal closure + +[Term] +id: GO:0090334 +name: regulation of cell wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells." [GOC:tb] +synonym: "regulation of cell wall 1,3-beta-D-glucan biosynthetic process" BROAD [] +synonym: "regulation of cell wall 1,3-beta-glucan biosynthetic process" BROAD [] +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0032953 ! regulation of (1->3)-beta-D-glucan biosynthetic process +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: regulates GO:0034411 ! cell wall (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0090335 +name: regulation of brown fat cell differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:tb] +is_a: GO:0045598 ! regulation of fat cell differentiation +relationship: regulates GO:0050873 ! brown fat cell differentiation + +[Term] +id: GO:0090336 +name: positive regulation of brown fat cell differentiation +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [GOC:BHF] +is_a: GO:0045600 ! positive regulation of fat cell differentiation +is_a: GO:0090335 ! regulation of brown fat cell differentiation +relationship: positively_regulates GO:0050873 ! brown fat cell differentiation + +[Term] +id: GO:0090337 +name: regulation of formin-nucleated actin cable assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] +is_a: GO:0032231 ! regulation of actin filament bundle assembly +relationship: regulates GO:0070649 ! formin-nucleated actin cable assembly + +[Term] +id: GO:0090338 +name: positive regulation of formin-nucleated actin cable assembly +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] +is_a: GO:0032233 ! positive regulation of actin filament bundle assembly +is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly +relationship: positively_regulates GO:0070649 ! formin-nucleated actin cable assembly + +[Term] +id: GO:0090339 +name: negative regulation of formin-nucleated actin cable assembly +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins." [GOC:jh, GOC:tb, PMID:12810699, PMID:15923184] +is_a: GO:0032232 ! negative regulation of actin filament bundle assembly +is_a: GO:0090337 ! regulation of formin-nucleated actin cable assembly +relationship: negatively_regulates GO:0070649 ! formin-nucleated actin cable assembly + +[Term] +id: GO:0090340 +name: positive regulation of secretion of lysosomal enzymes +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes +relationship: positively_regulates GO:0033299 ! secretion of lysosomal enzymes + +[Term] +id: GO:0090341 +name: negative regulation of secretion of lysosomal enzymes +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell." [GOC:BHF] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0090182 ! regulation of secretion of lysosomal enzymes +relationship: negatively_regulates GO:0033299 ! secretion of lysosomal enzymes + +[Term] +id: GO:0090342 +name: regulation of cell aging +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0007569 ! cell aging + +[Term] +id: GO:0090343 +name: positive regulation of cell aging +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0090342 ! regulation of cell aging +relationship: positively_regulates GO:0007569 ! cell aging + +[Term] +id: GO:0090344 +name: negative regulation of cell aging +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of cell aging. Cell aging is the progression of the cell from its inception to the end of its lifespan." [GOC:BHF, GOC:dph, GOC:tb] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0090342 ! regulation of cell aging +relationship: negatively_regulates GO:0007569 ! cell aging + +[Term] +id: GO:0090345 +name: cellular organohalogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0090346 +name: cellular organofluorine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0090345 ! cellular organohalogen metabolic process + +[Term] +id: GO:0090347 +name: regulation of cellular organohalogen metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0090345 ! cellular organohalogen metabolic process + +[Term] +id: GO:0090348 +name: regulation of cellular organofluorine metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process +relationship: regulates GO:0090346 ! cellular organofluorine metabolic process + +[Term] +id: GO:0090349 +name: negative regulation of cellular organohalogen metabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0090347 ! regulation of cellular organohalogen metabolic process +relationship: negatively_regulates GO:0090345 ! cellular organohalogen metabolic process + +[Term] +id: GO:0090350 +name: negative regulation of cellular organofluorine metabolic process +namespace: biological_process +def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." [GOC:BHF] +is_a: GO:0090348 ! regulation of cellular organofluorine metabolic process +is_a: GO:0090349 ! negative regulation of cellular organohalogen metabolic process +relationship: negatively_regulates GO:0090346 ! cellular organofluorine metabolic process + +[Term] +id: GO:0090351 +name: seedling development +namespace: biological_process +def: "The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge." [GOC:tb, PO:0007131] +xref: PO:0008037 +is_a: GO:0009791 ! post-embryonic development + +[Term] +id: GO:0090352 +name: regulation of nitrate assimilation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances." [GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process +relationship: regulates GO:0042128 ! nitrate assimilation + +[Term] +id: GO:0090353 +name: polygalacturonase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of polygalacturonase." [GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0090354 +name: regulation of auxin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] +synonym: "regulation of auxin metabolism" EXACT [GOC:tb] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +relationship: regulates GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0090355 +name: positive regulation of auxin metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] +synonym: "positive regulation of auxin metabolism" EXACT [GOC:tb] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0090354 ! regulation of auxin metabolic process +relationship: positively_regulates GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0090356 +name: negative regulation of auxin metabolic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth." [GOC:tb] +synonym: "negative regulation of auxin metabolism" EXACT [GOC:tb] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0090354 ! regulation of auxin metabolic process +relationship: negatively_regulates GO:0009850 ! auxin metabolic process + +[Term] +id: GO:0090357 +name: regulation of tryptophan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] +synonym: "regulation of tryptophan metabolism" EXACT [GOC:tb] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +relationship: regulates GO:0006568 ! tryptophan metabolic process + +[Term] +id: GO:0090358 +name: positive regulation of tryptophan metabolic process +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:tb] +synonym: "positive regulation of tryptophan metabolism" EXACT [GOC:tb] +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:0090357 ! regulation of tryptophan metabolic process +relationship: positively_regulates GO:0006568 ! tryptophan metabolic process + +[Term] +id: GO:0090359 +name: negative regulation of abscisic acid biosynthetic process +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:tb] +synonym: "negative regulation of abscisic acid biosynthesis" EXACT [GOC:tb] +is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0009688 ! abscisic acid biosynthetic process + +[Term] +id: GO:0090360 +name: platelet-derived growth factor production +namespace: biological_process +def: "The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0090361 +name: regulation of platelet-derived growth factor production +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0090360 ! platelet-derived growth factor production + +[Term] +id: GO:0090362 +name: positive regulation of platelet-derived growth factor production +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0090361 ! regulation of platelet-derived growth factor production +relationship: positively_regulates GO:0090360 ! platelet-derived growth factor production + +[Term] +id: GO:0090363 +name: regulation of proteasome core complex assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles." [GOC:dph, GOC:elh, GOC:tb] +is_a: GO:0090364 ! regulation of proteasome assembly +relationship: regulates GO:0080129 ! proteasome core complex assembly + +[Term] +id: GO:0090364 +name: regulation of proteasome assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:dph, GOC:elh, GOC:tb] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0043248 ! proteasome assembly + +[Term] +id: GO:0090365 +name: regulation of mRNA modification +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb, PMID:14559896] +synonym: "regulation of mRNA editing" NARROW [] +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: regulates GO:0016556 ! mRNA modification + +[Term] +id: GO:0090366 +name: positive regulation of mRNA modification +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0090365 ! regulation of mRNA modification +is_a: GO:1903313 ! positive regulation of mRNA metabolic process +relationship: positively_regulates GO:0016556 ! mRNA modification + +[Term] +id: GO:0090367 +name: negative regulation of mRNA modification +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:dph, GOC:sl, GOC:tb] +is_a: GO:0090365 ! regulation of mRNA modification +is_a: GO:1903312 ! negative regulation of mRNA metabolic process +relationship: negatively_regulates GO:0016556 ! mRNA modification + +[Term] +id: GO:0090368 +name: regulation of ornithine metabolic process +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +relationship: regulates GO:0006591 ! ornithine metabolic process + +[Term] +id: GO:0090369 +name: ornithine carbamoyltransferase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase." [GOC:dph, GOC:jp, GOC:tb] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0090370 +name: negative regulation of cholesterol efflux +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:dph, GOC:tb, GOC:yaf] +is_a: GO:0010874 ! regulation of cholesterol efflux +is_a: GO:0032375 ! negative regulation of cholesterol transport +relationship: negatively_regulates GO:0033344 ! cholesterol efflux + +[Term] +id: GO:0090371 +name: regulation of glycerol transport +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015793 ! glycerol transport + +[Term] +id: GO:0090372 +name: positive regulation of glycerol transport +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0090371 ! regulation of glycerol transport +relationship: positively_regulates GO:0015793 ! glycerol transport + +[Term] +id: GO:0090373 +name: negative regulation of glycerol transport +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:jh, GOC:tb] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0090371 ! regulation of glycerol transport +relationship: negatively_regulates GO:0015793 ! glycerol transport + +[Term] +id: GO:0090374 +name: oligopeptide export from mitochondrion +namespace: biological_process +def: "The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [PMID:11251115] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0090375 +name: negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:tb] +synonym: "negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency" EXACT [GOC:tb] +is_a: GO:0033217 ! regulation of transcription from RNA polymerase II promoter in response to iron ion starvation +is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0090376 +name: seed trichome differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function." [GOC:tb, PMID:17905721] +synonym: "cotton fiber development" NARROW [GOC:tb] +synonym: "seed hair differentiation" EXACT [PO:0004511] +synonym: "seed trichome development" RELATED [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010026 ! trichome differentiation +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0090377 +name: seed trichome initiation +namespace: biological_process +def: "The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis." [PMID:17905721] +comment: These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp. +synonym: "seed trichome fate commitment" EXACT [GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0045165 ! cell fate commitment +relationship: part_of GO:0090376 ! seed trichome differentiation + +[Term] +id: GO:0090378 +name: seed trichome elongation +namespace: biological_process +def: "The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [GOC:tb] +comment: The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp. +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009826 ! unidimensional cell growth +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0090376 ! seed trichome differentiation + +[Term] +id: GO:0090379 +name: secondary cell wall biogenesis involved in seed trichome differentiation +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete." [GOC:tb] +comment: The processes involved in the massive amount of secondary wall cellulose synthesis in seed trichomes continue to 30 DPA in Gossypium spp. +synonym: "secondary cell wall biosynthesis involved in seed trichome differentiation" EXACT [GOC:tb] +synonym: "seed trichome secondary wall biosynthesis" RELATED [GOC:tb] +is_a: GO:0009834 ! plant-type secondary cell wall biogenesis +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0090376 ! seed trichome differentiation + +[Term] +id: GO:0090380 +name: seed trichome maturation +namespace: biological_process +def: "A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state." [GOC:tb] +comment: These processes continue to 60 DPA in Gossypium spp. +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0048469 ! cell maturation +relationship: part_of GO:0090376 ! seed trichome differentiation + +[Term] +id: GO:0090381 +name: regulation of heart induction +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:dph, GOC:tb] +is_a: GO:0003156 ! regulation of animal organ formation +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000826 ! regulation of heart morphogenesis +relationship: regulates GO:0003129 ! heart induction + +[Term] +id: GO:0090382 +name: phagosome maturation +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0090383 +name: phagosome acidification +namespace: biological_process +def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion." [GOC:kmv, GOC:tb] +synonym: "phagosomal acidification" EXACT [GOC:kmv, GOC:tb] +is_a: GO:0051452 ! intracellular pH reduction +relationship: part_of GO:0090382 ! phagosome maturation + +[Term] +id: GO:0090384 +name: phagosome-lysosome docking +namespace: biological_process +def: "The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] +synonym: "lysosome recruitment to phagosome" EXACT [GOC:kmv, GOC:tb] +is_a: GO:0048278 ! vesicle docking +relationship: part_of GO:0001845 ! phagolysosome assembly + +[Term] +id: GO:0090385 +name: phagosome-lysosome fusion +namespace: biological_process +def: "The creation of a phagolysosome from a phagosome and a lysosome." [GOC:kmv, GOC:tb] +is_a: GO:0006906 ! vesicle fusion +relationship: part_of GO:0001845 ! phagolysosome assembly + +[Term] +id: GO:0090386 +name: phagosome maturation involved in apoptotic cell clearance +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome." [GOC:kmv, GOC:tb] +is_a: GO:0090382 ! phagosome maturation +relationship: part_of GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:0090387 +name: phagolysosome assembly involved in apoptotic cell clearance +namespace: biological_process +def: "The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] +is_a: GO:0001845 ! phagolysosome assembly +relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance + +[Term] +id: GO:0090388 +name: phagosome-lysosome docking involved in apoptotic cell clearance +namespace: biological_process +def: "The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere." [GOC:kmv, GOC:tb] +is_a: GO:0090384 ! phagosome-lysosome docking +relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance + +[Term] +id: GO:0090389 +name: phagosome-lysosome fusion involved in apoptotic cell clearance +namespace: biological_process +def: "The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] +is_a: GO:0090385 ! phagosome-lysosome fusion +relationship: part_of GO:0090387 ! phagolysosome assembly involved in apoptotic cell clearance + +[Term] +id: GO:0090390 +name: phagosome acidification involved in apoptotic cell clearance +namespace: biological_process +def: "Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance." [GOC:kmv, GOC:tb] +is_a: GO:0090383 ! phagosome acidification +relationship: part_of GO:0090386 ! phagosome maturation involved in apoptotic cell clearance + +[Term] +id: GO:0090391 +name: granum assembly +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts." [GOC:tb] +synonym: "grana formation" EXACT [GOC:tb] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0009658 ! chloroplast organization + +[Term] +id: GO:0090392 +name: sepal giant cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C." [GOC:tb, PMID:20485493] +is_a: GO:0090627 ! plant epidermal cell differentiation + +[Term] +id: GO:0090393 +name: sepal giant cell development +namespace: biological_process +def: "The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:tb] +synonym: "sepal giant cell formation" RELATED [GOC:tb] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0090392 ! sepal giant cell differentiation + +[Term] +id: GO:0090394 +name: negative regulation of excitatory postsynaptic potential +namespace: biological_process +def: "Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:BHF] +synonym: "negative regulation of EPSP" RELATED [] +synonym: "negative regulation of excitatory post-synaptic membrane potential" EXACT [] +synonym: "reduction of excitatory postsynaptic membrane potential" EXACT [GOC:bf] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:0098815 ! modulation of excitatory postsynaptic potential +relationship: negatively_regulates GO:0060079 ! excitatory postsynaptic potential + +[Term] +id: GO:0090395 +name: plant cell papilla +namespace: cellular_component +def: "A cell projection that is a short, rounded projection from a plant epidermal cell." [GOC:tb] +comment: Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001). +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0090396 +name: leaf papilla +namespace: cellular_component +def: "A plant cell papilla that is part of a leaf papilla cell." [GOC:tb] +comment: Part of leaf papilla cell (PO:0025167). +is_a: GO:0090395 ! plant cell papilla + +[Term] +id: GO:0090397 +name: stigma papilla +namespace: cellular_component +def: "A plant cell papilla that is part of a stigma papilla cell." [GOC:tb] +comment: Part of stigma papilla cell (PO:0025168). +is_a: GO:0090395 ! plant cell papilla + +[Term] +id: GO:0090398 +name: cellular senescence +namespace: biological_process +def: "A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest." [GOC:BHF] +is_a: GO:0007569 ! cell aging +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0090399 +name: replicative senescence +namespace: biological_process +def: "A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging." [GOC:BHF] +is_a: GO:0007569 ! cell aging + +[Term] +id: GO:0090400 +name: stress-induced premature senescence +namespace: biological_process +def: "A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays." [GOC:BHF] +synonym: "SIPS" EXACT [GOC:BHF] +is_a: GO:0090398 ! cellular senescence + +[Term] +id: GO:0090401 +name: obsolete viral-induced premature senescence +namespace: biological_process +def: "OBSOLETE. A cellular senescence process associated with the dismantling of a cell as a response to viral infection." [GOC:BHF] +comment: The reason for obsoletion is was not clearly defined. There is nothing in the literature that mentions this process; there are papers that mention viral proteins overcoming premature senescence, for example, PMID:22326283. +is_obsolete: true + +[Term] +id: GO:0090402 +name: oncogene-induced cell senescence +namespace: biological_process +def: "A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family." [GOC:BHF] +synonym: "OIS" EXACT [GOC:BHF] +is_a: GO:0090398 ! cellular senescence + +[Term] +id: GO:0090403 +name: oxidative stress-induced premature senescence +namespace: biological_process +def: "A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals." [GOC:BHF] +is_a: GO:0090400 ! stress-induced premature senescence +relationship: part_of GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:0090404 +name: pollen tube tip +namespace: cellular_component +def: "The region at growing end of the pollen tube cell, where polarized growth occurs." [GOC:tb, PO:0025195, PO:0025281] +is_a: GO:0035838 ! growing cell tip +relationship: part_of GO:0090406 ! pollen tube + +[Term] +id: GO:0090405 +name: unicellular trichome branch +namespace: cellular_component +def: "A cell projection part that is a branch of a unicellular trichome." [GOC:tb, PO:0025537] +comment: Unicellular trichome (PO:0025537) is a trichome(PO:0000282) that is a single plant cell (PO:0009002). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163). +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0090406 +name: pollen tube +namespace: cellular_component +def: "A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain." [GOC:tb, PO:0025195, PO:0025281] +comment: Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195). +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0090407 +name: organophosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0090408 +name: phloem nitrate loading +namespace: biological_process +def: "The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:tb] +is_a: GO:0015706 ! nitrate transport +is_a: GO:0110126 ! phloem loading + +[Term] +id: GO:0090409 +name: malonyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate." [MetaCyc:RXN-12359] +xref: EC:6.2.1.n3 +xref: MetaCyc:RXN-12359 +xref: RHEA:32139 +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0090410 +name: malonate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of malonate, the propanedioate ion." [GOC:tb] +is_a: GO:0043649 ! dicarboxylic acid catabolic process + +[Term] +id: GO:0090411 +name: brassinosteroid binding +namespace: molecular_function +def: "Binding to a brassinosteroid." [GOC:tb] +is_a: GO:0005496 ! steroid binding + +[Term] +id: GO:0090412 +name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT [] +is_obsolete: true +consider: GO:0045944 + +[Term] +id: GO:0090413 +name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process." [GOC:vw] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process" EXACT [] +is_obsolete: true +consider: GO:0000122 + +[Term] +id: GO:0090414 +name: molybdate ion export from vacuole +namespace: biological_process +def: "The directed movement of molybdate ions out of the vacuole." [GOC:tb] +is_a: GO:0015689 ! molybdate ion transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:0090415 +name: 7-hydroxymethyl chlorophyll a reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O." [GOC:kad, PMID:21934147] +is_a: GO:0052592 ! oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor + +[Term] +id: GO:0090416 +name: nicotinate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of nicotinate from one side of a membrane to the other." [GOC:tb] +xref: Reactome:R-HSA-8869603 "SLC22A13 transports NCA from extracellular region to cytosol" +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0090417 +name: N-methylnicotinate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of N-methylnicotinate from one side of a membrane to the other." [GOC:tb] +synonym: "N-methylnicotinate transporter activity" RELATED [] +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity + +[Term] +id: GO:0090418 +name: obsolete positive regulation of transcription involved in S-phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle." [PMID:16912276] +comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. +synonym: "activation of S phase specific transcription in the mitotic cell cycle" RELATED [] +synonym: "activation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] +synonym: "activation of transcription involved in S phase of mitotic cell cycle" RELATED [] +synonym: "positive regulation of S phase specific transcription in the mitotic cell cycle" RELATED [] +synonym: "positive regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] +synonym: "positive regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] +synonym: "up-regulation of S phase specific transcription in the mitotic cell cycle" RELATED [] +synonym: "up-regulation of transcription from RNA polymerase II promoter during S phase of the mitotic cell cycle" RELATED [] +synonym: "up-regulation of transcription involved in S phase of mitotic cell cycle" RELATED [] +is_obsolete: true +consider: GO:0000083 +consider: GO:0045944 + +[Term] +id: GO:0090419 +name: negative regulation of transcription involved in G2/M transition of mitotic cell cycle +namespace: biological_process +def: "Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:10747051] +synonym: "down-regulation of transcription from RNA polymerase II promoter during the G2/M transition of the mitotic cell cycle" RELATED [] +synonym: "negative regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle" RELATED [] +is_a: GO:0000117 ! regulation of transcription involved in G2/M transition of mitotic cell cycle +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated + +[Term] +id: GO:0090420 +name: obsolete naphthalene-containing compound metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving naphthalene-containing compounds." [GOC:dph, GOC:tb] +comment: This term was obsoleted because it is a unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0090421 +name: embryonic meristem initiation +namespace: biological_process +def: "Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation." [GOC:tb] +is_a: GO:0010014 ! meristem initiation + +[Term] +id: GO:0090422 +name: thiamine pyrophosphate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other." [GOC:tb] +synonym: "thiamine diphosphate transporter activity" EXACT [GOC:tb] +synonym: "thiamine pyrophosphate transporter activity" NARROW [] +xref: Reactome:R-HSA-8875838 "SLC25A19 transports ThDP from cytosol to mitochondrial matrix" +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015234 ! thiamine transmembrane transporter activity +is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity + +[Term] +id: GO:0090423 +name: phytochelatin-metal complex formation +namespace: biological_process +def: "A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex." [GOC:tb] +synonym: "low molecular weight phytochelatin complex formation" RELATED [] +synonym: "LWM phytochelatin complex formation" RELATED [] +is_a: GO:0046937 ! phytochelatin metabolic process + +[Term] +id: GO:0090424 +name: phytochelatin-metal-sulfur complex formation +namespace: biological_process +def: "A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex." [GOC:tb] +synonym: "high molecular weight phytochelatin complex formation" RELATED [] +synonym: "HWM phytochelatin complex formation" RELATED [] +is_a: GO:0046937 ! phytochelatin metabolic process + +[Term] +id: GO:0090425 +name: acinar cell differentiation +namespace: biological_process +def: "The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini." [GOC:dph, GOC:tb] +is_a: GO:0002067 ! glandular epithelial cell differentiation + +[Term] +id: GO:0090426 +name: actin filament bundle convergence +namespace: biological_process +def: "A process of actin filament bundle distribution that results in the compaction of actin filaments." [GOC:dph, GOC:tb] +is_a: GO:0070650 ! actin filament bundle distribution + +[Term] +id: GO:0090427 +name: activation of meiosis +namespace: biological_process +def: "Any process that starts the inactive process of meiosis." [GOC:dph, GOC:tb] +is_a: GO:0045836 ! positive regulation of meiotic nuclear division + +[Term] +id: GO:0090428 +name: perianth development +namespace: biological_process +def: "The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals." [GOC:tb, PO:0009058] +is_a: GO:0048438 ! floral whorl development + +[Term] +id: GO:0090429 +name: detection of endogenous biotic stimulus +namespace: biological_process +def: "The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal." [GOC:dph, GOC:tb] +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0009726 ! detection of endogenous stimulus + +[Term] +id: GO:0090430 +name: caffeoyl-CoA: alcohol caffeoyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA." [GOC:pz] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0090431 +name: alkyl caffeate ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate." [GOC:pz] +synonym: "alkyl caffeate ester anabolism" EXACT [GOC:tb] +synonym: "alkyl caffeate ester biosynthesis" EXACT [GOC:tb] +synonym: "alkyl caffeate ester formation" EXACT [GOC:tb] +synonym: "alkyl caffeate ester synthesis" EXACT [GOC:tb] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0009802 ! cinnamic acid ester biosynthetic process + +[Term] +id: GO:0090432 +name: myristoyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA." [GOC:al, PMID:18071249] +synonym: "myristoyl-CoA synthetase activity" EXACT [] +is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0090433 +name: palmitoyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA." [GOC:al, PMID:18071249] +synonym: "palmitoyl-CoA synthetase activity" EXACT [] +xref: Reactome:R-HSA-434382 "ACSL3,4 ligates coenzyme A (CoA-SH) to palmitate yielding palmitoyl-coenzyme A in the pancreatic beta cell" +is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0090434 +name: oleoyl-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA." [GOC:al, PMID:18071249] +synonym: "oleoyl-CoA synthetase activity" EXACT [] +is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0090435 +name: protein localization to nuclear envelope +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location within a nuclear envelope." [GOC:tb] +synonym: "protein localization in nuclear envelope" EXACT [] +is_a: GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:0090436 +name: leaf pavement cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate." [GOC:tb] +is_a: GO:0048468 ! cell development +relationship: part_of GO:0048366 ! leaf development + +[Term] +id: GO:0090437 +name: socket cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support." [GOC:tb] +is_a: GO:0090627 ! plant epidermal cell differentiation +relationship: part_of GO:0090558 ! plant epidermis development + +[Term] +id: GO:0090438 +name: camelliol C synthase activity +namespace: molecular_function +def: "Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C." [GOC:tb, PMID:17985917] +synonym: "(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming)" EXACT [] +is_a: GO:0016866 ! intramolecular transferase activity + +[Term] +id: GO:0090439 +name: tetraketide alpha-pyrone synthase activity +namespace: molecular_function +def: "Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A ." [MetaCyc:RXN-12183, PMID:21193570] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0090440 +name: abscisic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of abscisic acid from one side of a membrane to the other." [GOC:tb] +synonym: "abscisic acid transporter activity" EXACT [] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0090441 +name: trehalose biosynthesis in response to heat stress +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb] +synonym: "trehalose biosynthetic process in response to heat stress" EXACT systematic_synonym [GOC:tb] +is_a: GO:0005992 ! trehalose biosynthetic process +is_a: GO:0070414 ! trehalose metabolism in response to heat stress + +[Term] +id: GO:0090442 +name: trehalose catabolism in response to heat stress +namespace: biological_process +def: "The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:dph, GOC:tb] +synonym: "trehalose catabolic process in response to heat stress" EXACT systematic_synonym [GOC:tb] +is_a: GO:0005993 ! trehalose catabolic process +is_a: GO:0070414 ! trehalose metabolism in response to heat stress +relationship: part_of GO:0010353 ! response to trehalose + +[Term] +id: GO:0090443 +name: FAR/SIN/STRIPAK complex +namespace: cellular_component +def: "A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body." [GOC:vw, PMID:21561862, PMID:22119525] +synonym: "FAR complex" RELATED [GOC:vw] +synonym: "SIP complex" EXACT [PMID:22119525] +synonym: "striatin interacting phosphatase and kinase complex" EXACT [GOC:vw] +synonym: "STRIPAK signalling complex" RELATED [GOC:vw] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0090444 +name: regulation of nematode larval development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:17550772] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:0061062 ! regulation of nematode larval development + +[Term] +id: GO:0090445 +name: positive regulation of nematode larval development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached." [PMID:17550772] +is_a: GO:0045962 ! positive regulation of development, heterochronic +is_a: GO:0061063 ! positive regulation of nematode larval development +is_a: GO:0090444 ! regulation of nematode larval development, heterochronic + +[Term] +id: GO:0090446 +name: negative regulation of nematode larval development, heterochronic +namespace: biological_process +def: "Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached." [PMID:17550772] +is_a: GO:0045961 ! negative regulation of development, heterochronic +is_a: GO:0061064 ! negative regulation of nematode larval development +is_a: GO:0090444 ! regulation of nematode larval development, heterochronic + +[Term] +id: GO:0090447 +name: glycerol-3-phosphate 2-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.198] +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0090448 +name: glucosinolate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in)." [PMID:22864417] +synonym: "glucosinolate:hydrogen symporter activity" EXACT [] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0090449 +name: phloem glucosinolate loading +namespace: biological_process +def: "The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [PMID:22864417] +is_a: GO:0110126 ! phloem loading +is_a: GO:1901349 ! glucosinolate transport + +[Term] +id: GO:0090451 +name: cotyledon boundary formation +namespace: biological_process +def: "The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained." [GOC:tb] +is_a: GO:0090691 ! formation of plant organ boundary + +[Term] +id: GO:0090452 +name: lithium ion transmembrane transport +namespace: biological_process +def: "The directed movement of lithium ions across a membrane." [GOC:tb] +synonym: "lithium ion import" NARROW [] +synonym: "lithium ion uptake" EXACT [GOC:tb] +is_a: GO:0010351 ! lithium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:0090453 +name: aspartate transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of aspartate into the vacuole across the vacuolar membrane." [GOC:tb] +synonym: "vacuolar aspartate import" EXACT [GOC:tb] +is_a: GO:0015740 ! C4-dicarboxylate transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0034487 ! vacuolar amino acid transmembrane transport +is_a: GO:0043090 ! amino acid import +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0090454 +name: glutamate transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb] +synonym: "vacuolar glutamate import" RELATED [GOC:tb] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0090455 +name: ornithine transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of ornithine into the vacuole across the vacuolar membrane." [GOC:tb] +synonym: "vacuolar ornithine import" RELATED [GOC:tb] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0015822 ! ornithine transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0043090 ! amino acid import +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0090459 +name: aspartate homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell." [GOC:tb] +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090460 +name: threonine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of threonine within an organism or cell." [GOC:tb] +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090461 +name: glutamate homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell." [GOC:tb] +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090462 +name: ornithine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell." [GOC:tb] +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090463 +name: lysine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of lysine within an organism or cell." [GOC:tb] +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090464 +name: histidine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of histidine within an organism or cell." [GOC:tb] +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090465 +name: arginine homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of arginine within an organism or cell." [GOC:tb] +is_a: GO:0055080 ! cation homeostasis +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0080144 ! amino acid homeostasis + +[Term] +id: GO:0090470 +name: shoot organ boundary specification +namespace: biological_process +def: "The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained." [PMID:18757555] +is_a: GO:0090691 ! formation of plant organ boundary + +[Term] +id: GO:0090471 +name: 9,15,9'-tri-cis-zeta-carotene isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene." [EC:5.2.1.12] +synonym: "9,15,9'-tricis-zeta-carotene cis-trans-isomerase" RELATED [] +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0090472 +name: dibasic protein processing +namespace: biological_process +def: "Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein." [GOC:al] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0090473 +name: lys-arg specific dibasic protein processing +namespace: biological_process +def: "Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein." [GOC:al] +is_a: GO:0090472 ! dibasic protein processing + +[Term] +id: GO:0090474 +name: arg-arg specific dibasic protein processing +namespace: biological_process +def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein." [GOC:al] +is_a: GO:0090472 ! dibasic protein processing + +[Term] +id: GO:0090475 +name: lys-lys specific dibasic protein processing +namespace: biological_process +def: "Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein." [GOC:al] +is_a: GO:0090472 ! dibasic protein processing + +[Term] +id: GO:0090480 +name: purine nucleotide-sugar transmembrane transport +namespace: biological_process +alt_id: GO:0036079 +def: "The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "purine nucleotide-sugar membrane transport" EXACT [] +synonym: "purine nucleotide-sugar transport" RELATED [] +is_a: GO:0015780 ! nucleotide-sugar transmembrane transport + +[Term] +id: GO:0090481 +name: pyrimidine nucleotide-sugar transmembrane transport +namespace: biological_process +alt_id: GO:0015781 +def: "The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "pyrimidine nucleotide-sugar membrane transport" EXACT [] +synonym: "pyrimidine nucleotide-sugar transport" RELATED [] +is_a: GO:0015780 ! nucleotide-sugar transmembrane transport + +[Term] +id: GO:0090482 +name: vitamin transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0051183 +def: "Enables the transfer of a vitamin from one side of a membrane to the other." [GOC:tb] +synonym: "vitamin or cofactor transporter activity" BROAD [] +synonym: "vitamin transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:0090483 +name: phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine." [PMID:22988102] +synonym: "cardiolipin synthase" RELATED [GOC:tb] +is_a: GO:0030572 ! phosphatidyltransferase activity + +[Term] +id: GO:0090485 +name: obsolete chromosome number maintenance +namespace: biological_process +def: "OBSOLETE. The maintenance of the standard number of chromosomes in a cell." [GOC:tb] +comment: The reason for obsoletion is that this term represents a phenotype, and could be captured by other terms such as GO:0007059 chromosome segregation or GO:1903467 negative regulation of mitotic DNA replication initiation. +synonym: "diploidization" RELATED [GOC:tb] +synonym: "haploidization" RELATED [GOC:tb] +is_obsolete: true +consider: GO:0007059 +consider: GO:1903467 + +[Term] +id: GO:0090486 +name: small RNA 2'-O-methyltransferase +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide." [EC:2.1.1.n8, GOC:tb, GOC:vw] +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0090487 +name: secondary metabolite catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:tb] +synonym: "secondary metabolite breakdown" EXACT [GOC:tb] +synonym: "secondary metabolite catabolism" EXACT [GOC:tb] +synonym: "secondary metabolite degradation" EXACT [GOC:tb] +is_a: GO:0009056 ! catabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:0090488 +name: polo box domain specific binding +namespace: molecular_function +def: "Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases." [GOC:al, GOC:tb, Pfam:PF00659, PMID:12352953] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0090489 +name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) +namespace: molecular_function +def: "Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O." [EC:1.14.13.125, KEGG_REACTION:R08160] +synonym: "tryptophan N-monooxygenase activity" RELATED [] +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0090490 +name: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) +namespace: molecular_function +def: "Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09583] +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0090491 +name: N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) +namespace: molecular_function +def: "Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O." [KEGG_REACTION:R09584] +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0090492 +name: N,N-Dihydroxy-L-tryptophan decarboxylase activity +namespace: molecular_function +def: "Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O." [KEGG_REACTION:R09585] +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0090493 +name: catecholamine uptake +namespace: biological_process +def: "The directed movement of catecholamine into a cell." [GOC:dph, GOC:tb] +is_a: GO:0051937 ! catecholamine transport +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0090494 +name: dopamine uptake +namespace: biological_process +def: "The directed movement of dopamine into a cell." [GOC:dph, GOC:tb] +is_a: GO:0015872 ! dopamine transport +is_a: GO:0090493 ! catecholamine uptake + +[Term] +id: GO:0090495 +name: low-density lipoprotein particle disassembly +namespace: biological_process +def: "The disaggregation of a low-density lipoprotein particle into its constituent components." [GOC:dph, GOC:tb] +is_a: GO:0071829 ! plasma lipoprotein particle disassembly + +[Term] +id: GO:0090496 +name: mesenchyme migration involved in limb bud formation +namespace: biological_process +def: "The migration of mesenchymal tissue that contributes to the formation of a limb bud." [GOC:dph, GOC:tb] +is_a: GO:0090131 ! mesenchyme migration +relationship: part_of GO:0060174 ! limb bud formation + +[Term] +id: GO:0090497 +name: mesenchymal cell migration +namespace: biological_process +def: "The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism." [GOC:dph, GOC:tb] +is_a: GO:0001667 ! ameboidal-type cell migration + +[Term] +id: GO:0090498 +name: extrinsic component of Golgi membrane +namespace: cellular_component +def: "The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, PMID:21337012] +synonym: "extrinsic to Golgi membrane" NARROW [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0000139 ! Golgi membrane + +[Term] +id: GO:0090499 +name: pimelyl-[acyl-carrier protein] methyl ester esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol." [EC:3.1.1.85, PMID:23045647] +comment: Note that while this reaction occurs on a modified protein (acyl-carrier protein), the ACP only acts as a carrier that later releases the end product. +synonym: "pimelyl-[acyl-carrier protein] methyl ester hydrolase activity" RELATED [] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0090500 +name: endocardial cushion to mesenchymal transition +namespace: biological_process +def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, GOC:tb] +is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition + +[Term] +id: GO:0090501 +name: RNA phosphodiester bond hydrolysis +namespace: biological_process +def: "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] +is_a: GO:0016070 ! RNA metabolic process +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis + +[Term] +id: GO:0090502 +name: RNA phosphodiester bond hydrolysis, endonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] +is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis + +[Term] +id: GO:0090503 +name: RNA phosphodiester bond hydrolysis, exonucleolytic +namespace: biological_process +def: "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] +is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis + +[Term] +id: GO:0090504 +name: epiboly +namespace: biological_process +def: "The expansion of one cell sheet over other cells or yolk." [GOC:dph, GOC:tb] +is_a: GO:0002011 ! morphogenesis of an epithelial sheet + +[Term] +id: GO:0090505 +name: epiboly involved in wound healing +namespace: biological_process +def: "The expansion of one cell sheet over other cells involved in wound healing." [GOC:dph, GOC:tb] +is_a: GO:0090504 ! epiboly +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:0090506 +name: axillary shoot meristem initiation +namespace: biological_process +def: "A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf." [GOC:tb] +synonym: "axillary bud meristem initiation" RELATED [] +is_a: GO:0010014 ! meristem initiation +relationship: part_of GO:0010223 ! secondary shoot formation + +[Term] +id: GO:0090507 +name: phenylethylamine metabolic process involved in synaptic transmission +namespace: biological_process +def: "The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission." [GOC:tb] +is_a: GO:0042133 ! neurotransmitter metabolic process +is_a: GO:0042443 ! phenylethylamine metabolic process +relationship: part_of GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0090508 +name: phenylethylamine biosynthetic process involved in synaptic transmission +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission." [GOC:tb] +is_a: GO:0042136 ! neurotransmitter biosynthetic process +is_a: GO:0042444 ! phenylethylamine biosynthetic process +is_a: GO:0090507 ! phenylethylamine metabolic process involved in synaptic transmission + +[Term] +id: GO:0090510 +name: anticlinal cell division +namespace: biological_process +def: "A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file." [GOC:tair_curators, PMID:21391814] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0090511 +name: periclinal cell division +namespace: biological_process +def: "A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file." [GOC:tair_curators, PMID:21391814] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0090512 +name: eisosome membrane domain/MCC +namespace: cellular_component +def: "A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins." [GOC:al, GOC:vw, PMID:22368779] +is_a: GO:0044853 ! plasma membrane raft +relationship: part_of GO:0032126 ! eisosome + +[Term] +id: GO:0090513 +name: L-histidine transmembrane import into vacuole +namespace: biological_process +alt_id: GO:0090457 +def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al] +synonym: "histidine transmembrane import into vacuole" BROAD [] +synonym: "vacuolar histidine import" BROAD [GOC:tb] +is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:1902024 ! L-histidine transport + +[Term] +id: GO:0090514 +name: L-tyrosine transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of L-tyrosine into the vacuole across the vacuolar membrane." [GOC:al] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015828 ! tyrosine transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0090515 +name: L-glutamate transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0051938 ! L-glutamate import +is_a: GO:0090454 ! glutamate transmembrane import into vacuole + +[Term] +id: GO:0090516 +name: L-serine transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of L-serine into the vacuole across the vacuolar membrane." [GOC:al] +is_a: GO:0015825 ! L-serine transport +is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0090517 +name: L-lysine transmembrane import into vacuole +namespace: biological_process +alt_id: GO:0090456 +def: "The directed movement of L-lysine into the vacuole across the vacuolar membrane." [GOC:al] +synonym: "lysine transmembrane import into vacuole" BROAD [] +synonym: "vacuolar lysine import" BROAD [GOC:tb] +is_a: GO:0015819 ! lysine transport +is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole +is_a: GO:1903401 ! L-lysine transmembrane transport + +[Term] +id: GO:0090518 +name: L-arginine transmembrane import into vacuole +namespace: biological_process +alt_id: GO:0090458 +def: "The directed movement of L-arginine into the vacuole across the vacuolar membrane." [GOC:al] +synonym: "arginine transmembrane import into vacuole" BROAD [] +synonym: "vacuolar arginine import" EXACT [GOC:tb] +is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole +is_a: GO:1903826 ! L-arginine transmembrane transport + +[Term] +id: GO:0090519 +name: anoxia protection +namespace: biological_process +def: "Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia." [GOC:tb, PMID:19372430] +is_a: GO:0034059 ! response to anoxia + +[Term] +id: GO:0090520 +name: sphingolipid mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by a sphingolipid." [PMID:9525917] +synonym: "ceramide 1-phosphate signaling pathway" NARROW [PMID:20870412] +synonym: "ceramide signaling pathway" NARROW [PMID:20870412] +synonym: "sphingolipid mediated signal transduction" EXACT [GOC:signaling] +synonym: "sphingolipid signaling pathway" RELATED [] +synonym: "sphingolipid-mediated signaling pathway" EXACT [GOC:signaling] +synonym: "sphingosine signaling pathway" NARROW [PMID:20870412] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0090521 +name: glomerular visceral epithelial cell migration +namespace: biological_process +def: "The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell." [GOC:pm, PMID:21402783] +synonym: "podocyte cell migration" RELATED [GOC:pm] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0090522 +name: vesicle tethering involved in exocytosis +namespace: biological_process +def: "The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [GOC:rn, PMID:10559876, PMID:17052174, PMID:17488620, PMID:22420621, PMID:27243008] +synonym: "vesicle tethering to plasma membrane" NARROW [] +is_a: GO:0099022 ! vesicle tethering +is_a: GO:0140029 ! exocytic process + +[Term] +id: GO:0090523 +name: cytochrome-b5 reductase activity, acting on NADPH +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5)." [GOC:tb, RHEA:64576] +synonym: "cytochrome-b5 reductase activity" BROAD [] +xref: RHEA:64576 +is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H + +[Term] +id: GO:0090524 +name: cytochrome-b5 reductase activity, acting on NADH +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [GOC:tb] +synonym: "cytochrome b5 reductase activity" BROAD [] +is_a: GO:0004128 ! cytochrome-b5 reductase activity, acting on NAD(P)H + +[Term] +id: GO:0090527 +name: actin filament reorganization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments." [GOC:dph, GOC:tb] +is_a: GO:0007015 ! actin filament organization +relationship: part_of GO:0031532 ! actin cytoskeleton reorganization + +[Term] +id: GO:0090528 +name: smooth septate junction assembly +namespace: biological_process +def: "The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:22854041] +is_a: GO:0019991 ! septate junction assembly + +[Term] +id: GO:0090529 +name: cell septum assembly +namespace: biological_process +alt_id: GO:0090530 +def: "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:mtg_cell_cycle] +synonym: "cell septum assembly involved in cell cycle cytokinesis" EXACT [] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0032506 ! cytokinetic process + +[Term] +id: GO:0090531 +name: L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose." [GOC:yaf, PMID:11153268] +synonym: "L-ascorbic acid biosynthesis via GDP-alpha-D-mannose" RELATED [] +synonym: "Smirnoff-Wheeler's pathway" RELATED [] +xref: BioCyc:PWY-882 +is_a: GO:0019853 ! L-ascorbic acid biosynthetic process + +[Term] +id: GO:0090532 +name: L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate." [BioCyc:PWY3DJ-35471, GOC:yaf, PMID:11153268, UniPathway:UPA00991] +comment: This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans. +synonym: "L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate" RELATED [] +is_a: GO:0019853 ! L-ascorbic acid biosynthetic process + +[Term] +id: GO:0090533 +name: cation-transporting ATPase complex +namespace: cellular_component +def: "Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:BHF] +is_a: GO:0098533 ! ATPase dependent transmembrane transport complex + +[Term] +id: GO:0090534 +name: calcium ion-transporting ATPase complex +namespace: cellular_component +def: "Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in)." [GOC:BHF] +is_a: GO:0090533 ! cation-transporting ATPase complex + +[Term] +id: GO:0090535 +name: WICH complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair." [GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0090536 +name: NoRC complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters." [GOC:krc] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0090537 +name: CERF complex +namespace: cellular_component +def: "An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters." [GOC:krc] +is_a: GO:0031010 ! ISWI-type complex + +[Term] +id: GO:0090538 +name: peptide pheromone secretion +namespace: biological_process +def: "The regulated release of a peptide pheromone from a cell." [GOC:al, GOC:tb, GOC:vw] +is_a: GO:0000770 ! peptide pheromone export +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:0090539 +name: peptide pheromone export by transmembrane transport +namespace: biological_process +def: "The directed movement of a peptide pheromone across a membrane and out of a cell." [GOC:al, GOC:tb, GOC:vw] +synonym: "peptide pheromone export by membrane transport" EXACT [] +is_a: GO:0000770 ! peptide pheromone export +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0090540 +name: bacterial cellulose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria." [DOI:10.1016/S0268-005X(87)80024-3, DOI:10.1023/A\:1009272904582, GOC:tb, GOC:yaf, UniPathway:UPA00694] +synonym: "bacterial cellulose biosynthesis" EXACT [GOC:yaf] +is_a: GO:0030244 ! cellulose biosynthetic process + +[Term] +id: GO:0090541 +name: MIT domain binding +namespace: molecular_function +def: "Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking." [GOC:pm, InterPro:IPR007330] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0090542 +name: ELYC domain binding +namespace: molecular_function +def: "Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC." [GOC:pm, PMID:18032582, PMID:19525971] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0090543 +name: Flemming body +namespace: cellular_component +def: "A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge." [GOC:pm, PMID:18641129, PMID:22522702] +synonym: "Midbody ring" RELATED [PMID:18329369] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030496 ! midbody + +[Term] +id: GO:0090545 +name: CHD-type complex +namespace: cellular_component +def: "A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure." [GOC:krc, GOC:tb, PMID:17350655] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0090546 +name: chlorophyll fluorescence +namespace: biological_process +def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light." [PMID:10938857] +is_a: GO:1990066 ! energy quenching + +[Term] +id: GO:0090547 +name: response to low humidity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere." [GOC:tb] +is_a: GO:0009270 ! response to humidity + +[Term] +id: GO:0090548 +name: response to nitrate starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate." [GOC:tair_curators] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0090549 +name: response to carbon starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source." [GOC:tair_curators, PMID:18245858] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0090550 +name: response to molybdenum starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum." [GOC:tair_curators] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0090551 +name: response to manganese starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese." [GOC:tair_curators] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0090552 +name: unicellular trichome apex +namespace: cellular_component +def: "A cell projection part that is the apical most portion of a unicellular trichome." [GOC:PO_curators, PO:0025537] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0090553 +name: unicellular trichome tip +namespace: cellular_component +def: "A cell projection part that is the apical most portion of a unicellular trichome apex." [GOC:PO_curators] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0090552 ! unicellular trichome apex + +[Term] +id: GO:0090554 +name: phosphatidylcholine floppase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, RHEA:38583] +synonym: "ATP-dependent phosphatidylcholine transporter activity" BROAD [] +synonym: "ATPase-coupled phosphatidylcholine transporter activity" BROAD [] +synonym: "phosphatidylcholine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "phosphatidylcholine-translocating ATPase activity" BROAD [] +xref: RHEA:38583 +is_a: GO:0008525 ! phosphatidylcholine transporter activity +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0090555 +name: phosphatidylethanolamine flippase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36440] +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane). +synonym: "ATP-dependent phosphatidylethanolamine transporter activity" RELATED [] +synonym: "ATPase-coupled phosphatidylethanolamine transporter activity" BROAD [] +synonym: "phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +synonym: "phosphatidylethanolamine-translocating ATPase activity" RELATED [] +xref: RHEA:66132 +is_a: GO:0140333 ! glycerophospholipid flippase activity + +[Term] +id: GO:0090556 +name: phosphatidylserine floppase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:ab, PMID:16452632, PMID:20224745, RHEA:38567] +synonym: "ATPase-coupled phosphatidylserine transporter activity" BROAD [] +synonym: "ATPase-dependent phosphatidylserine transporter activity" BROAD [] +synonym: "phosphatidylserine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "phosphatidylserine-translocating ATPase activity" BROAD [] +xref: RHEA:38567 +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0090557 +name: establishment of endothelial intestinal barrier +namespace: biological_process +def: "The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition." [GOC:krc, PMID:22155109] +is_a: GO:0061028 ! establishment of endothelial barrier + +[Term] +id: GO:0090558 +name: plant epidermis development +namespace: biological_process +def: "The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure." [GOC:tb] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:0090559 +name: regulation of membrane permeability +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane." [GOC:kmv, PMID:22677064] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0090560 +name: 2-(3-amino-3-carboxypropyl)histidine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]." [GOC:pde, PMID:15485916] +xref: EC:2.5.1.108 +xref: MetaCyc:RXN-11371 +xref: Reactome:R-HSA-5358494 "DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2" +xref: RHEA:36783 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0090561 +name: nuclear migration during mitotic telophase +namespace: biological_process +def: "The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis." [GOC:vw, PMID:23087209] +is_a: GO:0030473 ! nuclear migration along microtubule + +[Term] +id: GO:0090562 +name: protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0090563 +name: protein-phosphocysteine-sugar phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0022804 ! active transmembrane transporter activity + +[Term] +id: GO:0090564 +name: protein-phosphocysteine-glucose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090565 +name: protein-phosphocysteine-mannitol phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:am] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090566 +name: protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in)." [GOC:am, PMID:10913119] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090567 +name: reproductive shoot system development +namespace: biological_process +def: "The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure." [GOC:pj] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048367 ! shoot system development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0090570 +name: RNA polymerase I transcription repressor complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter." [GOC:tb] +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090571 +name: RNA polymerase II transcription repressor complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter." [GOC:tb] +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090572 +name: RNA polymerase III transcription repressor complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter." [GOC:tb] +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090573 +name: RNA polymerase IV transcription repressor complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter." [GOC:tb] +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090574 +name: RNA polymerase V transcription repressor complex +namespace: cellular_component +def: "A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter." [GOC:tb] +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090575 +name: RNA polymerase II transcription regulator complex +namespace: cellular_component +def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II." [GOC:tb] +synonym: "RNA polymerase II transcription factor complex" NARROW [] +is_a: GO:0005667 ! transcription regulator complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:0090576 +name: RNA polymerase III transcription regulator complex +namespace: cellular_component +def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III." [GOC:tb] +synonym: "RNA polymerase III transcription factor complex" NARROW [] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0090577 +name: RNA polymerase IV transcription regulator complex +namespace: cellular_component +def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV." [GOC:tb] +synonym: "RNA polymerase IV transcription factor complex" NARROW [] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0090578 +name: RNA polymerase V transcription regulator complex +namespace: cellular_component +def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V." [GOC:tb] +synonym: "RNA polymerase V transcription factor complex" NARROW [] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0090579 +name: obsolete dsDNA loop formation +namespace: biological_process +def: "OBSOLETE. The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule." [GOC:jh, PMID:15950878] +comment: This term was obsoleted because it was defined like a molecular function. +synonym: "chromatin looping" RELATED [GOC:dph] +synonym: "dsDNA looping" EXACT [GOC:dph] +is_obsolete: true +consider: GO:0140587 + +[Term] +id: GO:0090580 +name: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands +namespace: molecular_function +def: "Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand." [GOC:pde, GOC:rb, PMID:11238902] +is_a: GO:0008081 ! phosphoric diester hydrolase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0090581 +name: protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in)." [PMID:14645248] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090582 +name: protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in)." [PMID:8626640] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090583 +name: protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in)." [PMID:8875915] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090584 +name: protein-phosphocysteine-galactitol-phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in)." [PMID:8955298] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090585 +name: protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in)." [PMID:15153772] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090586 +name: protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in)." [PMID:8246840] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090587 +name: protein-phosphocysteine-glucosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in)." [PMID:8246840] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090588 +name: protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in)." [PMID:15060041] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090589 +name: protein-phosphocysteine-trehalose phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in)." [PMID:7608078] +is_a: GO:0090563 ! protein-phosphocysteine-sugar phosphotransferase activity + +[Term] +id: GO:0090590 +name: protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in)." [PMID:8246840] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0090591 +name: protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity +namespace: molecular_function +def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in)." [PMID:9864311] +is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity + +[Term] +id: GO:0090592 +name: DNA synthesis involved in DNA replication +namespace: biological_process +def: "Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA." [GOC:vw] +is_a: GO:0071897 ! DNA biosynthetic process +relationship: part_of GO:0006260 ! DNA replication + +[Term] +id: GO:0090593 +name: peptidyl-histidine autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein." [PMID:15947782, PMID:8962061] +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:0090594 +name: inflammatory response to wounding +namespace: biological_process +def: "The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents." [GOC:add] +is_a: GO:0006954 ! inflammatory response +is_a: GO:0009611 ! response to wounding + +[Term] +id: GO:0090595 +name: acetyl-CoA:L-lysine N6-acetyltransferase +namespace: molecular_function +def: "Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+)." [MetaCyc:LYSACET-RXN] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0090596 +name: sensory organ morphogenesis +namespace: biological_process +def: "Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:kmv, ISBN:978-0199210893] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0007423 ! sensory organ development + +[Term] +id: GO:0090597 +name: nematode male tail mating organ morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules." [GOC:kmv, PMID:1782863, PMID:18050419, PMID:7409314] +is_a: GO:0048808 ! male genitalia morphogenesis +is_a: GO:0090596 ! sensory organ morphogenesis + +[Term] +id: GO:0090598 +name: male anatomical structure morphogenesis +namespace: biological_process +def: "The processes by which anatomical structures that are only present in the male organism are generated and organized." [GOC:kmv, GOC:tb] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0046661 ! male sex differentiation + +[Term] +id: GO:0090599 +name: alpha-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb] +xref: EC:3.2.1.20 +xref: Reactome:R-HSA-9036727 "GAA hydrolyzes lysosomal glycogen" +xref: Reactome:R-HSA-9036729 "Defective GAA does not hydrolyze lysosomal glycogen" +is_a: GO:0015926 ! glucosidase activity + +[Term] +id: GO:0090600 +name: alpha-1,3-glucosidase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose." [GOC:sd, GOC:tb] +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0090601 +name: enucleation +namespace: biological_process +def: "The process in which nucleated precursor cells lose their nucleus." [GOC:tb] +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:0090602 +name: sieve element enucleation +namespace: biological_process +def: "The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded." [GOC:tb, PMID:25081480] +is_a: GO:0090601 ! enucleation +relationship: part_of GO:0090603 ! sieve element differentiation + +[Term] +id: GO:0090603 +name: sieve element differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of a sieve element." [GOC:tb] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0090604 +name: surface biofilm formation +namespace: biological_process +def: "A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] +is_a: GO:0042710 ! biofilm formation + +[Term] +id: GO:0090605 +name: submerged biofilm formation +namespace: biological_process +def: "A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] +synonym: "solid substrate biofilm formation" RELATED [] +is_a: GO:0042710 ! biofilm formation + +[Term] +id: GO:0090606 +name: single-species surface biofilm formation +namespace: biological_process +alt_id: GO:0032022 +def: "A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface." [GOC:ml] +synonym: "multicellular pellicle formation" RELATED [] +is_a: GO:0044010 ! single-species biofilm formation +is_a: GO:0090604 ! surface biofilm formation + +[Term] +id: GO:0090609 +name: single-species submerged biofilm formation +namespace: biological_process +def: "A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, GOC:tb] +is_a: GO:0044010 ! single-species biofilm formation +is_a: GO:0090605 ! submerged biofilm formation + +[Term] +id: GO:0090610 +name: bundle sheath cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:tb, PMID:24517883] +is_a: GO:0001708 ! cell fate specification + +[Term] +id: GO:0090611 +name: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination." [PMID:22547407] +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:0090612 +name: cAMP deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3." [PMID:24074367, RHEA:22908] +synonym: "cyclic adenosine monophosphate deaminase activity" EXACT [] +xref: EC:3.5.4.46 +xref: RHEA:22908 +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0090613 +name: 5'-deoxyadenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3." [PMID:23968233, RHEA:42892] +xref: EC:3.5.4.41 +xref: RHEA:42892 +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0090614 +name: 5'-methylthioadenosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3." [PMID:23968233, RHEA:25025] +xref: EC:3.5.4.31 +xref: RHEA:25025 +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0090615 +name: mitochondrial mRNA processing +namespace: biological_process +def: "Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs." [GOC:tb, PMID:25181358] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0006397 ! mRNA processing + +[Term] +id: GO:0090616 +name: mitochondrial mRNA 3'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358] +is_a: GO:0000965 ! mitochondrial RNA 3'-end processing +is_a: GO:0031124 ! mRNA 3'-end processing +is_a: GO:0090615 ! mitochondrial mRNA processing + +[Term] +id: GO:0090617 +name: mitochondrial mRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome." [GOC:tb, PMID:25181358] +is_a: GO:0090615 ! mitochondrial mRNA processing + +[Term] +id: GO:0090618 +name: DNA clamp unloading +namespace: biological_process +def: "The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates." [GOC:rb, PMID:23499004] +synonym: "PCNA unloading" RELATED [GOC:rb, PMID:23499004] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0090619 +name: meiotic spindle pole +namespace: cellular_component +def: "Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:ha, PMID:18250200] +is_a: GO:0000922 ! spindle pole +relationship: part_of GO:0072687 ! meiotic spindle + +[Term] +id: GO:0090620 +name: obsolete APC-Cdc20 complex +namespace: cellular_component +def: "OBSOLETE. An anaphase promoting complex bound to the fizzy family APC activator Cdc20/Slp1 which regulates the metaphase anaphase transition by activating the APC/C to target the anaphase inhibitor securin and promotes sister chromatid separation." [GOC:vw, PMID:10921876] +comment: This term was made obsolete because it is too fine-grained for GO. Consider Complex Portal EBI-1252490, Anaphase-Promoting Complex variant 2 as an alternate term. +synonym: "APC-fizzy complex" EXACT [GOC:vw] +synonym: "APC-Slp1 complex" EXACT [GOC:vw] +synonym: "mitotic anaphase promotic complex" RELATED [GOC:vw] +is_obsolete: true +consider: GO:0005680 + +[Term] +id: GO:0090621 +name: obsolete APC-fizzy-related complex +namespace: cellular_component +def: "OBSOLETE. An anaphase promoting complex bound to the fizzy-related family APC activator FZR1/Cdh1/Srw1 that regulates mitotic exit by activating the APC/C to target mitotic cyclins for destruction during anaphase and telophase. Is also active during G1." [GOC:vw, PMID:10921876] +comment: This term was made obsolete because it is too fine-grained for GO. +synonym: "APC-Hct1/Cdh1 complex" EXACT [GOC:vw] +synonym: "APC-Srw1 complex" EXACT [GOC:vw] +is_obsolete: true +consider: GO:0005680 + +[Term] +id: GO:0090624 +name: endoribonuclease activity, cleaving miRNA-paired mRNA +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970, PMID:19239888] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:0090625 +name: mRNA destabilization-mediated gene silencing by siRNA +namespace: biological_process +def: "The process in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:15260970] +synonym: "mRNA cleavage involved in gene silencing by siRNA" EXACT [] +is_a: GO:0035194 ! post-transcriptional gene silencing by RNA +is_a: GO:0098795 ! mRNA destabilization-mediated gene silencing + +[Term] +id: GO:0090626 +name: plant epidermis morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the plant epidermis are generated and organized." [GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0090558 ! plant epidermis development + +[Term] +id: GO:0090627 +name: plant epidermal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell." [GOC:tb] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:0090628 +name: plant epidermal cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:tb] +is_a: GO:0001708 ! cell fate specification +relationship: part_of GO:0090627 ! plant epidermal cell differentiation + +[Term] +id: GO:0090629 +name: lagging strand initiation +namespace: biological_process +def: "The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started." [GOC:mah, GOC:tb] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0006273 ! lagging strand elongation + +[Term] +id: GO:0090630 +name: activation of GTPase activity +namespace: biological_process +alt_id: GO:0032856 +alt_id: GO:0032857 +alt_id: GO:0032858 +alt_id: GO:0032859 +alt_id: GO:0032860 +alt_id: GO:0032861 +alt_id: GO:0032862 +alt_id: GO:0032863 +alt_id: GO:0032864 +def: "Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP." [GOC:dph, GOC:mah, GOC:tb] +synonym: "activation of ARF GTPase activity" NARROW [] +synonym: "activation of Cdc42 GTPase activity" NARROW [] +synonym: "activation of Rab GTPase activity" NARROW [] +synonym: "activation of Rac GTPase activity" NARROW [] +synonym: "activation of Ral GTPase activity" NARROW [] +synonym: "activation of Ran GTPase activity" NARROW [] +synonym: "activation of Rap GTPase activity" NARROW [] +synonym: "activation of Ras GTPase activity" NARROW [] +synonym: "activation of Rho GTPase activity" NARROW [] +synonym: "ARF GTPase activation" NARROW [] +synonym: "Cdc42 GTPase activation" NARROW [] +synonym: "Rab GTPase activation" NARROW [] +synonym: "Rac GTPase activation" NARROW [] +synonym: "Ral GTPase activation" NARROW [] +synonym: "Ran GTPase activation" NARROW [] +synonym: "Rap GTPase activation" NARROW [] +synonym: "Ras GTPase activation" NARROW [] +synonym: "Rho GTPase activation" NARROW [] +is_a: GO:0043547 ! positive regulation of GTPase activity + +[Term] +id: GO:0090632 +name: N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411] +synonym: "CMP-Neu5Gc synthetase activity" EXACT [] +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0090633 +name: keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN." [ISBN:978-1-60805-067-3, PMID:11479279, PMID:8381411] +synonym: "CMP-KDN synthetase activity" EXACT [] +synonym: "cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity" EXACT [] +is_a: GO:0070567 ! cytidylyltransferase activity + +[Term] +id: GO:0090634 +name: microglial cell mediated cytotoxicity +namespace: biological_process +def: "The directed killing of a target cell by a microglial cell." [GOC:BHF, GOC:nc, PMID:19100238] +is_a: GO:0001909 ! leukocyte mediated cytotoxicity +is_a: GO:0002444 ! myeloid leukocyte mediated immunity + +[Term] +id: GO:0090635 +name: extracellular core region of desmosome +namespace: cellular_component +def: "The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner." [PMID:20066089] +synonym: "desmoglea" EXACT [PMID:20066089] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030057 ! desmosome + +[Term] +id: GO:0090636 +name: outer dense plaque of desmosome +namespace: cellular_component +def: "The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane." [PMID:20066089] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030057 ! desmosome + +[Term] +id: GO:0090637 +name: inner dense plaque of desmosome +namespace: cellular_component +def: "The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane." [PMID:20066089] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030057 ! desmosome + +[Term] +id: GO:0090638 +name: phosphatidylcholine biosynthesis from phosphatidylethanolamine +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations." [MetaCyc:PWY-6825] +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0090639 +name: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine." [MetaCyc:PWY-6826] +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0090640 +name: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine +namespace: biological_process +def: "The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine." [MetaCyc:PWY-7470, PMID:24329598, PMID:27758859] +is_a: GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:0090641 +name: microsporidian-type endospore +namespace: cellular_component +def: "The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins." [PMID:19457051] +comment: Microsporidian biology uses the term endospore differently than GO:0043593 endospore coat which is for a spore formed inside of another cell. Microsporidian endospore refers to the inner layer of the spore wall itself. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031160 ! spore wall + +[Term] +id: GO:0090642 +name: microsporidian-type exospore +namespace: cellular_component +def: "The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore." [PMID:19457051, PMID:25363531] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031160 ! spore wall + +[Term] +id: GO:0090643 +name: inflorescence phyllotactic patterning +namespace: biological_process +def: "The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem." [PMID:25352850] +is_a: GO:0060771 ! phyllotactic patterning + +[Term] +id: GO:0090644 +name: age-related resistance +namespace: biological_process +def: "An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR)." [PMID:17635216, PMID:19694953] +synonym: "adult seedling resistance" NARROW [] +synonym: "ARR" EXACT [] +synonym: "developmental resistance" BROAD [] +synonym: "flowering-induced resistance" NARROW [] +synonym: "mature seedling resistance" NARROW [] +synonym: "ontogenic resistance" BROAD [] +synonym: "senescence-induced resistance" NARROW [] +is_a: GO:0032502 ! developmental process +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0090646 +name: mitochondrial tRNA processing +namespace: biological_process +def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw] +is_a: GO:0000963 ! mitochondrial RNA processing +is_a: GO:0008033 ! tRNA processing + +[Term] +id: GO:0090647 +name: modulation of age-related behavioral decline +namespace: biological_process +def: "Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory." [GOC:cjm, GOC:kmv, PMID:20523893] +is_a: GO:0065008 ! regulation of biological quality +relationship: part_of GO:0007568 ! aging + +[Term] +id: GO:0090648 +name: response to environmental enrichment +namespace: biological_process +def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment." [GOC:sl, PMID:23644055, PMID:25934034] +synonym: "response to the introduction of novel objects" NARROW [] +is_a: GO:0009605 ! response to external stimulus + +[Term] +id: GO:0090649 +name: response to oxygen-glucose deprivation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936] +synonym: "response to OGD" EXACT [GOC:sl] +is_a: GO:0031667 ! response to nutrient levels +is_a: GO:0036293 ! response to decreased oxygen levels + +[Term] +id: GO:0090650 +name: cellular response to oxygen-glucose deprivation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose." [GOC:sl, PMID:21525936] +synonym: "cellular response to OGD" EXACT [GOC:sl] +is_a: GO:0031669 ! cellular response to nutrient levels +is_a: GO:0036294 ! cellular response to decreased oxygen levels +is_a: GO:0090649 ! response to oxygen-glucose deprivation + +[Term] +id: GO:0090651 +name: apical cytoplasm +namespace: cellular_component +def: "The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0090652 +name: basolateral cytoplasm +namespace: cellular_component +def: "The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells." [PMID:17494872] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0090653 +name: apical recycling endosome +namespace: cellular_component +def: "Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells." [PMID:12669082, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315] +is_a: GO:0055037 ! recycling endosome +relationship: part_of GO:0090651 ! apical cytoplasm + +[Term] +id: GO:0090654 +name: basolateral recycling endosome +namespace: cellular_component +def: "Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells." [PMID:11389442, PMID:16394106, PMID:17494872, PMID:21170358, PMID:9405315] +is_a: GO:0055037 ! recycling endosome +relationship: part_of GO:0090652 ! basolateral cytoplasm + +[Term] +id: GO:0090655 +name: double-stranded/single-stranded junction telomeric DNA binding +namespace: molecular_function +def: "Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang." [GOC:BHF, GOC:BHF_telomere, GOC:bhm, GOC:nc, PMID:21852327] +is_a: GO:0000406 ! double-strand/single-strand DNA junction binding +is_a: GO:0042162 ! telomeric DNA binding + +[Term] +id: GO:0090656 +name: t-circle formation +namespace: biological_process +def: "A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD)." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19214183, PMID:19581589, PMID:19809492, PMID:19858100] +synonym: "telomeric circle formation" EXACT [] +is_a: GO:0001325 ! formation of extrachromosomal circular DNA +relationship: part_of GO:0090737 ! telomere maintenance via telomere trimming + +[Term] +id: GO:0090657 +name: telomeric loop disassembly +namespace: biological_process +def: "The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:22579284] +synonym: "T loop disassembly" EXACT [] +synonym: "t-loop disassembly" EXACT [] +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0090658 +name: cone matrix sheath +namespace: cellular_component +def: "A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments." [GOC:mr, PMID:2055688] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0033165 ! interphotoreceptor matrix + +[Term] +id: GO:0090659 +name: walking behavior +namespace: biological_process +def: "The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:tb] +synonym: "locomotor gait pattern" NARROW [] +is_a: GO:0007626 ! locomotory behavior + +[Term] +id: GO:0090660 +name: cerebrospinal fluid circulation +namespace: biological_process +def: "The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional." [GOC:mgi_curators, PMID:22100360, PMID:24229449] +synonym: "cerebrospinal fluid flow" EXACT [] +synonym: "CSF circulation" EXACT [] +synonym: "CSF flow" EXACT [] +is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement +is_a: GO:0050877 ! nervous system process + +[Term] +id: GO:0090661 +name: box H/ACA telomerase RNP complex +namespace: cellular_component +def: "A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283] +is_a: GO:0072588 ! box H/ACA RNP complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005697 ! telomerase holoenzyme complex + +[Term] +id: GO:0090663 +name: galanin-activated signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor." [GOC:lb, PMID:25691535] +synonym: "galanin signaling pathway" RELATED [] +synonym: "galanin signalling pathway" RELATED [] +synonym: "galanin-activated signalling pathway" EXACT [] +is_a: GO:0007218 ! neuropeptide signaling pathway + +[Term] +id: GO:0090664 +name: response to high population density +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area." [GOC:mr, PMID:26439857] +synonym: "response to crowding" EXACT [GOC:mr] +is_a: GO:0006950 ! response to stress +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0090665 +name: glycoprotein complex +namespace: cellular_component +def: "A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds." [GOC:pf, PMID:7693675, PMID:8662961] +comment: An example is the Dictyostelium multi protein pspB complex, which is secreted from prespore vesicles and incorporated into the spore coat. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0090666 +name: scaRNA localization to Cajal body +namespace: biological_process +def: "A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] +is_a: GO:0090670 ! RNA localization to Cajal body + +[Term] +id: GO:0090667 +name: cell chemotaxis to vascular endothelial growth factor +namespace: biological_process +def: "The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851] +is_a: GO:0060326 ! cell chemotaxis +relationship: part_of GO:0035924 ! cellular response to vascular endothelial growth factor stimulus + +[Term] +id: GO:0090668 +name: endothelial cell chemotaxis to vascular endothelial growth factor +namespace: biological_process +def: "The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF)." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21885851] +is_a: GO:0090667 ! cell chemotaxis to vascular endothelial growth factor + +[Term] +id: GO:0090669 +name: telomerase RNA stabilization +namespace: biological_process +def: "Prevention of degradation of telomerase RNA (TERC) molecules." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] +synonym: "TERC stabilization" EXACT [] +is_a: GO:0043489 ! RNA stabilization + +[Term] +id: GO:0090670 +name: RNA localization to Cajal body +namespace: biological_process +def: "A process in which an RNA is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] +is_a: GO:0090685 ! RNA localization to nucleus + +[Term] +id: GO:0090671 +name: telomerase RNA localization to Cajal body +namespace: biological_process +def: "A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] +is_a: GO:0090670 ! RNA localization to Cajal body +is_a: GO:0090672 ! telomerase RNA localization + +[Term] +id: GO:0090672 +name: telomerase RNA localization +namespace: biological_process +def: "Any process in which telomerase RNA is transported to, or maintained in, a specific location." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:25467444] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0090673 +name: endothelial cell-matrix adhesion +namespace: biological_process +def: "The binding of an endothelial cell to the extracellular matrix via adhesion molecules." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962] +is_a: GO:0007160 ! cell-matrix adhesion + +[Term] +id: GO:0090674 +name: endothelial cell-matrix adhesion via fibronectin +namespace: biological_process +def: "The binding of an endothelial cell to the extracellular matrix via fibronectin." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:19460962] +is_a: GO:0090673 ! endothelial cell-matrix adhesion + +[Term] +id: GO:0090675 +name: intermicrovillar adhesion +namespace: biological_process +def: "The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin." [GOC:lb, PMID:24725409] +is_a: GO:0022610 ! biological adhesion +relationship: part_of GO:1904970 ! brush border assembly + +[Term] +id: GO:0090676 +name: calcium ion transmembrane transport via low voltage-gated calcium channel +namespace: biological_process +def: "A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel." [GOC:bf, GOC:PARL, PMID:20371816] +synonym: "generation of T-type calcium current" RELATED [] +is_a: GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:0090677 +name: reversible differentiation +namespace: biological_process +def: "A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another." [GOC:curators] +is_a: GO:0036166 ! phenotypic switching + +[Term] +id: GO:0090678 +name: cell dedifferentiation involved in phenotypic switching +namespace: biological_process +def: "A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators] +is_a: GO:0043697 ! cell dedifferentiation +relationship: part_of GO:0090677 ! reversible differentiation + +[Term] +id: GO:0090679 +name: cell differentiation involved in phenotypic switching +namespace: biological_process +def: "A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations." [GOC:curators] +is_a: GO:0030154 ! cell differentiation +relationship: part_of GO:0090677 ! reversible differentiation + +[Term] +id: GO:0090680 +name: disruption by virus of host outer membrane +namespace: biological_process +def: "A process by which a virus has a negative effect on the functioning of a host outer membrane." [PMID:17900620] +is_a: GO:0044662 ! disruption by virus of host cell membrane + +[Term] +id: GO:0090681 +name: GPCR taste receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor activity that is responsible for the sense of taste." [GOC:hat, GOC:tb] +synonym: "G-protein coupled taste receptor activity" EXACT [] +synonym: "G-protein-coupled taste receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0090682 +name: GPCR bitter taste receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor activity that is responsible for the sense of bitter taste." [GOC:hat, GOC:tb] +synonym: "G protein-coupled receptor bitter taste receptor activity" EXACT [] +synonym: "G-protein coupled receptor bitter taste receptor activity" EXACT [] +is_a: GO:0033038 ! bitter taste receptor activity +is_a: GO:0090681 ! GPCR taste receptor activity + +[Term] +id: GO:0090683 +name: GPCR sweet taste receptor activity +namespace: molecular_function +def: "A G protein-coupled receptor activity that is responsible for the sense of sweet taste." [GOC:hat, GOC:tb] +synonym: "G-protein coupled receptor sweet taste receptor activity" EXACT [] +is_a: GO:0033041 ! sweet taste receptor activity +is_a: GO:0090681 ! GPCR taste receptor activity + +[Term] +id: GO:0090684 +name: contact chemoreceptor activity +namespace: molecular_function +def: "A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception." [GOC:hat, GOC:tb] +synonym: "contact chemosensation receptor activity" EXACT [] +is_a: GO:0008527 ! taste receptor activity + +[Term] +id: GO:0090685 +name: RNA localization to nucleus +namespace: biological_process +def: "A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus." [GOC:mah, PMID:26305931] +synonym: "RNA localisation to nucleus" EXACT [GOC:mah] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:0090686 +name: glycine betaine-activated nonselective monovalent cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a monovalent cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts." [GOC:kmv, PMID:24212673] +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0090687 +name: activation of meiosis I spindle assembly checkpoint +namespace: biological_process +def: "Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint." [GOC:mah] +is_a: GO:1905326 ! positive regulation of meiosis I spindle assembly checkpoint + +[Term] +id: GO:0090688 +name: cleavage furrow rim +namespace: cellular_component +def: "The part of the cleavage furrow closest to the cell surface." [GOC:vw, PMID:27082518] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032154 ! cleavage furrow + +[Term] +id: GO:0090689 +name: cleavage furrow leading edge +namespace: cellular_component +def: "The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring." [GOC:vw, PMID:27082518] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032154 ! cleavage furrow + +[Term] +id: GO:0090690 +name: obsolete heteroreceptor complex +namespace: cellular_component +def: "OBSOLETE. A receptor complex that consists of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger. The formation of the higher level complex initiates a change in cell function." [GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794] +comment: This term was obsoleted as it was created in error. +is_obsolete: true + +[Term] +id: GO:0090691 +name: formation of plant organ boundary +namespace: biological_process +def: "The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:tb] +is_a: GO:0048859 ! formation of anatomical boundary + +[Term] +id: GO:0090692 +name: mitochondrial membrane scission site +namespace: cellular_component +def: "The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission." [GOC:bc, GOC:PARL, PMID:26618722] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0090693 +name: plant organ senescence +namespace: biological_process +def: "The process that occurs in a plant organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb] +is_a: GO:0007568 ! aging +relationship: part_of GO:0099402 ! plant organ development + +[Term] +id: GO:0090694 +name: Scc2-Scc4 cohesin loading complex +namespace: cellular_component +def: "A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA." [GOC:vw, PMID:24291789] +synonym: "Mis4-Ssl3 cohesin loading complex" EXACT [GOC:vw] +is_a: GO:0032116 ! SMC loading complex + +[Term] +id: GO:0090695 +name: Wpl/Pds5 cohesin loading/unloading complex +namespace: cellular_component +def: "A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA." [GOC:vw, PMID:26687354] +is_a: GO:0032116 ! SMC loading complex + +[Term] +id: GO:0090696 +name: post-embryonic plant organ development +namespace: biological_process +def: "Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb] +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0099402 ! plant organ development + +[Term] +id: GO:0090697 +name: post-embryonic plant organ morphogenesis +namespace: biological_process +def: "Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:tb] +is_a: GO:0090698 ! post-embryonic plant morphogenesis +is_a: GO:1905392 ! plant organ morphogenesis +relationship: part_of GO:0090696 ! post-embryonic plant organ development + +[Term] +id: GO:0090698 +name: post-embryonic plant morphogenesis +namespace: biological_process +def: "The process, occurring after plant embryonic development, by which anatomical structures are generated and organized." [GOC:tb] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0090700 +name: maintenance of plant organ identity +namespace: biological_process +def: "The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb, PMID:9090883] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0099402 ! plant organ development + +[Term] +id: GO:0090701 +name: specification of plant organ identity +namespace: biological_process +def: "The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:1905393 ! plant organ formation + +[Term] +id: GO:0090703 +name: obsolete triplex DNA unwinding +namespace: biological_process +def: "OBSOLETE. The process by which a three-stranded D-loop DNA is unwound or 'melted'." [PMID:26503245] +comment: This term was made obsolete because it was created in error. +is_obsolete: true + +[Term] +id: GO:0090704 +name: nicotinate-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP." [GOC:tb, PMID:26116607] +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0090705 +name: trichome papilla +namespace: cellular_component +def: "A plant cell papilla that is part of a trichome cell." [GOC:tb, PMID:24014871] +comment: Part of trichome cell (PO:0008030). +is_a: GO:0090395 ! plant cell papilla + +[Term] +id: GO:0090706 +name: specification of plant organ position +namespace: biological_process +def: "The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ." [GOC:tb, PMID:9611175] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:0090707 +name: establishment of plant organ orientation +namespace: biological_process +def: "The process that determines the orientation of a plant organ or tissue with reference to an axis." [GOC:tb] +is_a: GO:0048560 ! establishment of anatomical structure orientation +relationship: part_of GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:0090708 +name: specification of plant organ axis polarity +namespace: biological_process +def: "The process in which the polarity of a plant organ axis is specified." [GOC:tb] +is_a: GO:0065001 ! specification of axis polarity +relationship: part_of GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:0090709 +name: regulation of timing of plant organ formation +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development." [GOC:tb] +is_a: GO:0040034 ! regulation of development, heterochronic +is_a: GO:1905428 ! regulation of plant organ formation + +[Term] +id: GO:0090710 +name: phosphomevalonate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate." [EC:4.1.1.99, MetaCyc:RXN-10067, PMID:24375100] +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0090711 +name: FMN hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: FMN + H2O = riboflavin + phosphate." [EC:3.1.3.102, PMID:16183635] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0090712 +name: basal pole of outer hair cell +namespace: cellular_component +def: "The end of the outer hair cell which receives and transmits neural signals." [GOC:sl, PMID:12845523] +is_a: GO:0060187 ! cell pole + +[Term] +id: GO:0090713 +name: immunological memory process +namespace: biological_process +def: "Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] +is_a: GO:0002376 ! immune system process +relationship: part_of GO:0006955 ! immune response + +[Term] +id: GO:0090714 +name: innate immunity memory response +namespace: biological_process +def: "An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus." [GOC:add, PMID:26086132] +is_a: GO:0045087 ! innate immune response +is_a: GO:0090713 ! immunological memory process + +[Term] +id: GO:0090715 +name: immunological memory formation process +namespace: biological_process +def: "Any immunological memory process that can contribute to the formation of immunological memory." [GOC:add, PMID:26086132, PMID:26831526] +is_a: GO:0090713 ! immunological memory process + +[Term] +id: GO:0090716 +name: adaptive immune memory response +namespace: biological_process +def: "An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526] +is_a: GO:0002250 ! adaptive immune response +is_a: GO:0090713 ! immunological memory process + +[Term] +id: GO:0090717 +name: adaptive immune memory response involving T cells and B cells +namespace: biological_process +def: "An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response." [GOC:add, PMID:26831526] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0090716 ! adaptive immune memory response + +[Term] +id: GO:0090718 +name: adaptive immune effector response +namespace: biological_process +def: "An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response." [GOC:add, ISBN:1405196831] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0090719 +name: adaptive immune effector response involving T cells and B lineage cells +namespace: biological_process +def: "An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells." [GOC:add, ISBN:1405196831] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0090718 ! adaptive immune effector response + +[Term] +id: GO:0090720 +name: primary adaptive immune response +namespace: biological_process +def: "An adaptive immune response against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526] +is_a: GO:0002250 ! adaptive immune response + +[Term] +id: GO:0090721 +name: primary adaptive immune response involving T cells and B cells +namespace: biological_process +def: "An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system." [GOC:add, PMID:26831526] +is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:0090720 ! primary adaptive immune response + +[Term] +id: GO:0090722 +name: receptor-receptor interaction +namespace: molecular_function +def: "The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function." [GOC:dox, GOC:pad, GOC:PARL, PMID:22035699, PMID:24157794] +synonym: "hetero-receptor complex formation" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0090723 +name: obsolete growth cone part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a growth cone, the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, GOC:tb] +is_obsolete: true +consider: GO:0030426 + +[Term] +id: GO:0090724 +name: central region of growth cone +namespace: cellular_component +def: "The center of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:0090725 +name: peripheral region of growth cone +namespace: cellular_component +def: "The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite." [GOC:sl, PMID:16260607] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:0090726 +name: cortical dynamic polarity patch +namespace: cellular_component +def: "A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation." [GOC:mah, PMID:23200991] +synonym: "dynamic polarity patch at the cell cortex" EXACT [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005938 ! cell cortex + +[Term] +id: GO:0090727 +name: positive regulation of brood size +namespace: biological_process +def: "Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] +is_a: GO:0060378 ! regulation of brood size + +[Term] +id: GO:0090728 +name: negative regulation of brood size +namespace: biological_process +def: "Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." [GOC:rz] +is_a: GO:0060378 ! regulation of brood size + +[Term] +id: GO:0090729 +name: toxin activity +namespace: molecular_function +alt_id: GO:0050827 +def: "Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom." [GOC:pt] +subset: goslim_generic +synonym: "toxin receptor binding" EXACT [] +xref: Wikipedia:Toxin +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0090730 +name: Las1 complex +namespace: cellular_component +def: "A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448)." [GOC:vw, PMID:26638174] +synonym: "Las1-Grc3-Rat1-Rai1" NARROW [GOC:vw] +is_a: GO:1902555 ! endoribonuclease complex +is_a: GO:1902911 ! protein kinase complex +is_a: GO:1905354 ! exoribonuclease complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0090731 +name: cellular response to very-low-density lipoprotein particle stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus." [GOC:aruk, GOC:bc] +synonym: "cellular response to VLDL particle stimulus" EXACT [] +is_a: GO:0055094 ! response to lipoprotein particle +is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus + +[Term] +id: GO:0090732 +name: cofilin-actin rod +namespace: cellular_component +def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers." [GOC:sl, PMID:22573689, PMID:24760020] +is_a: GO:0031002 ! actin rod + +[Term] +id: GO:0090733 +name: tenascin complex +namespace: cellular_component +def: "A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R." [GOC:bhm, PMID:11731446, PMID:12845616, PMID:17909022, PMID:23658023] +comment: An example is Tenascin-N (Q9UQP3) in PMID:17909022 (IDA). +synonym: "Tenascin-C" NARROW [] +synonym: "Tenascin-N" NARROW [] +synonym: "Tenascin-R" NARROW [] +synonym: "Tenascin-W" NARROW [] +synonym: "Tenascin-X" NARROW [] +is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0090734 +name: site of DNA damage +namespace: cellular_component +def: "A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:pg] +xref: Wikipedia:DNA_repair +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0090735 +name: DNA repair complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex." [GOC:pg, PMID:27113759, PMID:27233470] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0090736 +name: MATH domain binding +namespace: molecular_function +def: "Binding to a meprin and TRAF homology (MATH) domain." [InterPro:IPR002083, PMID:22621901] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0090737 +name: telomere maintenance via telomere trimming +namespace: biological_process +def: "A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:27918544] +is_a: GO:0000723 ! telomere maintenance + +[Term] +id: GO:0090740 +name: integral component of pigment granule membrane +namespace: cellular_component +def: "The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [PMID:11294610] +is_a: GO:0031301 ! integral component of organelle membrane +relationship: part_of GO:0090741 ! pigment granule membrane + +[Term] +id: GO:0090741 +name: pigment granule membrane +namespace: cellular_component +def: "Any membrane that is part of a pigment granule." [PMID:11294610] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0048770 ! pigment granule + +[Term] +id: GO:0093001 +name: glycolysis from storage polysaccharide through glucose-1-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH." [GOC:dph, GOC:glycolysis] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0061622 ! glycolytic process through glucose-1-phosphate + +[Term] +id: GO:0093002 +name: response to nematicide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes." [GOC:kvm, PMID:22301316] +synonym: "response to antihelmintic" EXACT [GOC:kvm] +synonym: "response to nematocide" EXACT [GOC:kvm] +is_a: GO:0009636 ! response to toxic substance + +[Term] +id: GO:0095500 +name: acetylcholine receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "acetylcholine receptor signalling pathway" EXACT [] +is_a: GO:0098926 ! postsynaptic signal transduction +relationship: part_of GO:1905145 ! cellular response to acetylcholine + +[Term] +id: GO:0097001 +name: ceramide binding +namespace: molecular_function +def: "Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes." [GOC:sart] +is_a: GO:0033218 ! amide binding +is_a: GO:0046625 ! sphingolipid binding + +[Term] +id: GO:0097002 +name: mitochondrial inner boundary membrane +namespace: cellular_component +def: "The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane." [GOC:mcc, PMID:16054341, PMID:19019989] +synonym: "inner bounding mitochondrial membrane" EXACT [NIF_Subcellular:sao18461326] +xref: NIF_Subcellular:sao18461326 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0097003 +name: adipokinetic hormone receptor activity +namespace: molecular_function +def: "Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] +synonym: "AKH receptor activity" EXACT [] +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:0097004 +name: adipokinetic hormone binding +namespace: molecular_function +def: "Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] +synonym: "AKH binding" EXACT [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0097005 +name: adipokinetic hormone receptor binding +namespace: molecular_function +def: "Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis." [GOC:sart, PMID:11904407] +synonym: "AKH receptor binding" EXACT [] +is_a: GO:0051428 ! peptide hormone receptor binding + +[Term] +id: GO:0097006 +name: regulation of plasma lipoprotein particle levels +namespace: biological_process +def: "Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism." [GOC:BHF] +synonym: "plasma lipoprotein particle homeostasis" NARROW [] +is_a: GO:0050789 ! regulation of biological process + +[Term] +id: GO:0097007 +name: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone." [GOC:kad, MetaCyc:RXN-8620, PMID:21088219] +synonym: "4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity" EXACT [] +synonym: "TMTT synthase activity" EXACT [] +xref: MetaCyc:RXN-8620 +xref: RHEA:13545 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0097008 +name: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone." [GOC:kad, MetaCyc:RXN-8619, PMID:21088219] +synonym: "(3E)-4,8-dimethylnona-1,3,7-triene synthase activity" EXACT [] +synonym: "DNMT synthase activity" RELATED [] +xref: MetaCyc:RXN-8619 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0097009 +name: energy homeostasis +namespace: biological_process +alt_id: GO:2000505 +alt_id: GO:2000506 +alt_id: GO:2000507 +def: "Any process involved in the balance between food intake (energy input) and energy expenditure." [GOC:yaf, PMID:15919751] +synonym: "negative regulation of energy homeostasis" RELATED [] +synonym: "positive regulation of energy homeostasis" RELATED [] +synonym: "regulation of energy homeostasis" RELATED [] +is_a: GO:0048871 ! multicellular organismal homeostasis + +[Term] +id: GO:0097010 +name: eukaryotic translation initiation factor 4F complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex." [GOC:BHF, GOC:ebc, PMID:18337562] +synonym: "eIF-4F assembly" EXACT [GOC:pr] +synonym: "eIF4F assembly" EXACT [GOC:pr] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0097011 +name: cellular response to granulocyte macrophage colony-stimulating factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:BHF, GOC:ebc, PMID:7901744] +synonym: "cellular response to GM-CSF stimulus" EXACT [] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:0097012 ! response to granulocyte macrophage colony-stimulating factor + +[Term] +id: GO:0097012 +name: response to granulocyte macrophage colony-stimulating factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus." [GOC:pr] +synonym: "response to GM-CSF" EXACT [] +synonym: "response to granulocyte macrophage colony-stimulating factor stimulus" EXACT [GOC:dos] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0097013 +name: phagocytic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a phagocytic vesicle." [GOC:rs] +is_a: GO:0071682 ! endocytic vesicle lumen +relationship: part_of GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:0097014 +name: ciliary plasm +namespace: cellular_component +def: "All of the contents of a cilium, excluding the plasma membrane surrounding the cilium." [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". +synonym: "cilial cytoplasm" RELATED [] +synonym: "ciliary cytoplasm" RELATED [] +synonym: "cilium cytoplasm" RELATED [] +synonym: "cilium plasm" EXACT [] +synonym: "microtubule-based flagellar cytoplasm" RELATED [] +synonym: "microtubule-based flagellar matrix" NARROW [] +synonym: "microtubule-based flagellum cytoplasm" RELATED [] +synonym: "microtubule-based flagellum matrix" NARROW [] +is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097015 +name: obsolete bacterial-type flagellar cytoplasm +namespace: cellular_component +def: "OBSOLETE. All of the contents of a bacterial-type flagellum, excluding the plasma membrane surrounding the flagellum." [GOC:BHF] +comment: The reason for obsoletion is that this term describes a cellular component that does not exist. +synonym: "bacterial-type flagellum cytoplasm" EXACT [] +is_obsolete: true + +[Term] +id: GO:0097016 +name: L27 domain binding +namespace: molecular_function +def: "Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner." [GOC:BHF, PMID:15241471, PMID:17237226, Prosite:PDOC51022] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0097017 +name: renal protein absorption +namespace: biological_process +def: "A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686)." [GOC:yaf, PMID:18431508] +is_a: GO:0070293 ! renal absorption + +[Term] +id: GO:0097018 +name: renal albumin absorption +namespace: biological_process +def: "A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron." [GOC:yaf, PMID:18431508] +is_a: GO:0097017 ! renal protein absorption + +[Term] +id: GO:0097019 +name: neurotransmitter receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors." [GOC:kmv] +synonym: "neurotransmitter receptor breakdown" EXACT [] +synonym: "neurotransmitter receptor catabolism" EXACT [] +synonym: "neurotransmitter receptor degradation" EXACT [] +is_a: GO:0032801 ! receptor catabolic process +is_a: GO:0045213 ! neurotransmitter receptor metabolic process + +[Term] +id: GO:0097020 +name: COPII receptor activity +namespace: molecular_function +def: "Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles." [GOC:rb, PMID:16957051, PMID:20236934] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0097021 +name: lymphocyte migration into lymphoid organs +namespace: biological_process +def: "The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] +synonym: "lymphocyte homing" NARROW [] +is_a: GO:0072676 ! lymphocyte migration + +[Term] +id: GO:0097022 +name: lymphocyte migration into lymph node +namespace: biological_process +def: "The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen." [GOC:BHF, GOC:pr, PMID:18379575] +synonym: "lymphocyte homing" EXACT [] +is_a: GO:0097021 ! lymphocyte migration into lymphoid organs + +[Term] +id: GO:0097023 +name: fructose 6-phosphate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate." [GOC:imk, PMID:11120740, PMID:21290439] +xref: RHEA:28002 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0097025 +name: MPP7-DLG1-LIN7 complex +namespace: cellular_component +def: "A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions." [GOC:BHF, PMID:17237226] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005912 ! adherens junction + +[Term] +id: GO:0097026 +name: dendritic cell dendrite assembly +namespace: biological_process +def: "Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, PMID:12200351] +comment: Note that dendrites of dendritic cells should not be confused with neuronal cell dendrites, which process electrical signals. +synonym: "dendritic extension" BROAD [] +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0097027 +name: ubiquitin-protein transferase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein." [GOC:rb, PMID:18321851] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0055106 ! ubiquitin-protein transferase regulator activity + +[Term] +id: GO:0097028 +name: dendritic cell differentiation +namespace: biological_process +def: "The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:pr] +comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. +is_a: GO:1903131 ! mononuclear cell differentiation + +[Term] +id: GO:0097029 +name: mature conventional dendritic cell differentiation +namespace: biological_process +def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx, PMID:15845453] +comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. +is_a: GO:0002573 ! myeloid leukocyte differentiation +is_a: GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:0097030 +name: CENP-A containing nucleosome binding +namespace: molecular_function +def: "Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:jp, PMID:21412236] +synonym: "centromere-specific nucleosome binding" RELATED [GOC:vw] +synonym: "centromeric nucleosome binding" RELATED [] +is_a: GO:0031491 ! nucleosome binding + +[Term] +id: GO:0097031 +name: obsolete mitochondrial respiratory chain complex I biogenesis +namespace: biological_process +def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex I, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +is_obsolete: true + +[Term] +id: GO:0097032 +name: obsolete mitochondrial respiratory chain complex II biogenesis +namespace: biological_process +def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex II, a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:pr] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +is_obsolete: true + +[Term] +id: GO:0097033 +name: obsolete mitochondrial respiratory chain complex III biogenesis +namespace: biological_process +def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex III (also known as cytochrome bc(1) complex or ubiquinol-cytochrome c reductase), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +synonym: "mitochondrial cytochrome bc(1) complex biogenesis" EXACT [GOC:pr] +is_obsolete: true + +[Term] +id: GO:0097034 +name: obsolete mitochondrial respiratory chain complex IV biogenesis +namespace: biological_process +def: "OBSOLETE. The biogenesis of a mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase complex), a protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Includes the synthesis of constituent proteins and their aggregation, arrangement and bonding together." [GOC:mcc] +comment: The reason for obsoletion is that 'biogenesis' as related to a protein is translation, and there is no indication that the members of these complexes are synthesized in a particular way. Historically biogenesis terms were created for some processes when the level of a molecule was changed by an unknown mechanism, for instance transcription, translation, assembly etc. This is now considered too indirect for annotation. +synonym: "mitochondrial cytochrome c oxidase complex biogenesis" EXACT [GOC:pr] +is_obsolete: true + +[Term] +id: GO:0097035 +name: regulation of membrane lipid distribution +namespace: biological_process +def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909] +is_a: GO:0061024 ! membrane organization +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0097036 +name: regulation of plasma membrane sterol distribution +namespace: biological_process +def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [GOC:mah, PMID:18441123, PMID:20823909] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0097035 ! regulation of membrane lipid distribution + +[Term] +id: GO:0097037 +name: heme export +namespace: biological_process +def: "The directed movement of heme out of a cell or organelle." [GOC:lf, PMID:15369674, PMID:20610401] +is_a: GO:0015886 ! heme transport + +[Term] +id: GO:0097038 +name: perinuclear endoplasmic reticulum +namespace: cellular_component +def: "The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes." [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] +synonym: "perinuclear ER" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005783 ! endoplasmic reticulum +relationship: part_of GO:0048471 ! perinuclear region of cytoplasm + +[Term] +id: GO:0097039 +name: protein linear polyubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein." [GOC:jsg, GOC:sp, PMID:21455173, PMID:21455180, PMID:21455181] +synonym: "M1 linkage" NARROW [] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:0097040 +name: phthiocerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents." [GOC:dph, GOC:ecd, PMID:9201977] +synonym: "phthiocerol anabolism" EXACT [] +synonym: "phthiocerol biosynthesis" EXACT [] +synonym: "phthiocerol formation" EXACT [] +synonym: "phthiocerol synthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0042845 ! glycol biosynthetic process + +[Term] +id: GO:0097041 +name: phenolic phthiocerol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position." [GOC:dph, GOC:ecd, PMID:9201977] +synonym: "phenolic phthiocerol anabolism" EXACT [] +synonym: "phenolic phthiocerol biosynthesis" EXACT [] +synonym: "phenolic phthiocerol formation" EXACT [] +synonym: "phenolic phthiocerol synthesis" EXACT [] +synonym: "phenolphthiocerol biosynthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process + +[Term] +id: GO:0097042 +name: extrinsic component of fungal-type vacuolar membrane +namespace: cellular_component +def: "The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:jh, PMID:21454883] +synonym: "extrinsic to fungal-type vacuolar membrane" NARROW [] +is_a: GO:0000306 ! extrinsic component of vacuolar membrane +relationship: part_of GO:0000329 ! fungal-type vacuole membrane + +[Term] +id: GO:0097043 +name: histone H3-K56 acetylation +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr] +is_a: GO:0043966 ! histone H3 acetylation + +[Term] +id: GO:0097044 +name: histone H3-K56 acetylation in response to DNA damage +namespace: biological_process +def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell." [GOC:pr, GOC:vw, PMID:18344406] +is_a: GO:0097043 ! histone H3-K56 acetylation +relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:0097045 +name: phosphatidylserine exposure on blood platelet +namespace: biological_process +def: "A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system." [GOC:bf, GOC:lf, GOC:pr, PMID:21107324] +is_a: GO:0017121 ! plasma membrane phospholipid scrambling +is_a: GO:0030194 ! positive regulation of blood coagulation + +[Term] +id: GO:0097046 +name: replication fork progression beyond termination site +namespace: biological_process +def: "Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks." [GOC:bf, GOC:mcc, GOC:pr, PMID:20797631] +is_a: GO:2000621 ! regulation of DNA replication termination + +[Term] +id: GO:0097047 +name: DNA replication termination region +namespace: cellular_component +def: "A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks." [GOC:mcc, GOC:pr, PMID:20797631] +synonym: "TER" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0097048 +name: dendritic cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, GOC:BHF, GOC:mtg_apoptosis, PMID:15059845] +synonym: "dendritic cell apoptosis" NARROW [] +is_a: GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:0097049 +name: motor neuron apoptotic process +namespace: biological_process +def: "Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:BHF, GOC:mtg_apoptosis, PMID:14523086] +synonym: "motoneuron apoptosis" EXACT [] +synonym: "motor neuron apoptosis" NARROW [] +is_a: GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0097050 +name: type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:BHF, GOC:mtg_apoptosis, PMID:16087305] +synonym: "pancreatic B cell apoptosis" EXACT [] +synonym: "pancreatic beta cell apoptosis" EXACT [] +synonym: "type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:0097051 +name: establishment of protein localization to endoplasmic reticulum membrane +namespace: biological_process +def: "The directed movement of a protein to a specific location in the endoplasmic reticulum membrane." [GOC:rb, PMID:9388185] +synonym: "establishment of protein localisation in endoplasmic reticulum membrane" EXACT [GOC:mah] +synonym: "establishment of protein localization in endoplasmic reticulum membrane" EXACT [] +is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum +is_a: GO:0090150 ! establishment of protein localization to membrane + +[Term] +id: GO:0097052 +name: L-kynurenine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [GOC:yaf] +synonym: "L-kynurenine metabolism" EXACT [] +is_a: GO:0070189 ! kynurenine metabolic process + +[Term] +id: GO:0097053 +name: L-kynurenine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine)." [GOC:yaf] +synonym: "L-kynurenine breakdown" EXACT [] +synonym: "L-kynurenine catabolism" EXACT [] +synonym: "L-kynurenine degradation" EXACT [] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0097052 ! L-kynurenine metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:0097054 +name: L-glutamate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid." [GOC:yaf] +synonym: "L-glutamate anabolism" EXACT [] +synonym: "L-glutamate biosynthesis" EXACT [] +synonym: "L-glutamate formation" EXACT [] +synonym: "L-glutamate synthesis" EXACT [] +is_a: GO:0006537 ! glutamate biosynthetic process + +[Term] +id: GO:0097055 +name: agmatine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase." [GOC:pr, GOC:yaf] +synonym: "agmatine anabolism" EXACT [] +synonym: "agmatine biosynthesis" EXACT [] +synonym: "agmatine formation" EXACT [] +synonym: "agmatine synthesis" EXACT [] +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:0097056 +name: selenocysteinyl-tRNA(Sec) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine." [GOC:yaf, PMID:15317934, UniPathway:UPA00906] +synonym: "selenocysteinyl-tRNA(Sec) anabolism" EXACT [] +synonym: "selenocysteinyl-tRNA(Sec) biosynthesis" EXACT [] +synonym: "selenocysteinyl-tRNA(Sec) formation" EXACT [] +synonym: "selenocysteinyl-tRNA(Sec) synthesis" EXACT [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:0097057 +name: TRAF2-GSTP1 complex +namespace: cellular_component +def: "A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses." [GOC:BHF, PMID:16636664] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097058 +name: CRLF-CLCF1 complex +namespace: cellular_component +def: "A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex." [GOC:BHF, PMID:10966616] +synonym: "CLF-CLC complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0097059 +name: CNTFR-CLCF1 complex +namespace: cellular_component +def: "A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space." [GOC:BHF, PMID:11285233] +synonym: "sCNTFR-CLC complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0097060 +name: synaptic membrane +namespace: cellular_component +def: "A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, PMID:20410104] +subset: goslim_synapse +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0045202 ! synapse + +[Term] +id: GO:0097061 +name: dendritic spine organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] +synonym: "dendritic spine organisation" EXACT [] +is_a: GO:0099173 ! postsynapse organization +is_a: GO:0106027 ! neuron projection organization + +[Term] +id: GO:0097062 +name: dendritic spine maintenance +namespace: biological_process +def: "The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission." [GOC:BHF, PMID:20410104] +is_a: GO:0043954 ! cellular component maintenance +is_a: GO:0097061 ! dendritic spine organization + +[Term] +id: GO:0097063 +name: cadmium ion sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++)." [GOC:rs, PMID:19456862] +is_a: GO:0046870 ! cadmium ion binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0097064 +name: ncRNA export from nucleus +namespace: biological_process +def: "The directed movement of a non-coding RNA transcript (ncRNA) from the nucleus to the cytoplasm." [GOC:dgf, PMID:11352936] +synonym: "non-coding RNA export from nucleus" EXACT [GOC:pr] +is_a: GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0097065 +name: anterior head development +namespace: biological_process +def: "The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure." [GOC:yaf, PMID:14695376, PMID:15857913] +is_a: GO:0060322 ! head development + +[Term] +id: GO:0097066 +name: response to thyroid hormone +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872] +synonym: "response to thyroid hormone stimulus" EXACT [GOC:dos] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:0097067 +name: cellular response to thyroid hormone stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus." [GOC:sjw, PMID:9916872] +is_a: GO:0032870 ! cellular response to hormone stimulus +is_a: GO:0097066 ! response to thyroid hormone + +[Term] +id: GO:0097068 +name: response to thyroxine +namespace: biological_process +def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872] +synonym: "response to T4" EXACT [Wikipedia:Thyroxine] +synonym: "response to T4 stimulus" EXACT [Wikipedia:Thyroxine] +synonym: "response to thyroxine stimulus" EXACT [GOC:dos] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid +is_a: GO:0097066 ! response to thyroid hormone +is_a: GO:1904386 ! response to L-phenylalanine derivative + +[Term] +id: GO:0097069 +name: cellular response to thyroxine stimulus +namespace: biological_process +def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus." [GOC:sjw, PMID:9916872] +synonym: "cellular response to T4 stimulus" EXACT [Wikipedia:Thyroxine] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0097067 ! cellular response to thyroid hormone stimulus +is_a: GO:0097068 ! response to thyroxine +is_a: GO:1904387 ! cellular response to L-phenylalanine derivative + +[Term] +id: GO:0097070 +name: ductus arteriosus closure +namespace: biological_process +def: "The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs." [GOC:hw] +is_a: GO:0048844 ! artery morphogenesis + +[Term] +id: GO:0097071 +name: interferon regulatory factor complex +namespace: cellular_component +def: "A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit." [GOC:cna, PMID:20043992] +synonym: "IRF complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097072 +name: interferon regulatory factor 3 complex +namespace: cellular_component +def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3." [GOC:cna, PMID:12855817, PMID:14556004, Reactome:R-HSA-166272] +synonym: "IRF3:IRF3 complex" EXACT [] +is_a: GO:0097071 ! interferon regulatory factor complex + +[Term] +id: GO:0097073 +name: interferon regulatory factor 5 complex +namespace: cellular_component +def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5." [GOC:cna, PMID:12138184, PMID:16751392] +synonym: "IRF5:IRF5 complex" EXACT [] +is_a: GO:0097071 ! interferon regulatory factor complex + +[Term] +id: GO:0097074 +name: interferon regulatory factor 7 complex +namespace: cellular_component +def: "An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:R-HSA-450344] +synonym: "IRF7:IRF7 complex" EXACT [] +is_a: GO:0097071 ! interferon regulatory factor complex + +[Term] +id: GO:0097075 +name: interferon regulatory factor 3-interferon regulatory factor 7 complex +namespace: cellular_component +def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7." [GOC:cna, PMID:18068231, Reactome:R-HSA-1027367] +synonym: "IRF3:IRF7 complex" EXACT [] +is_a: GO:0097071 ! interferon regulatory factor complex + +[Term] +id: GO:0097076 +name: transforming growth factor beta activated kinase 1 complex +namespace: cellular_component +def: "A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits)." [GOC:cna, PMID:16410796, PMID:17496917, PMID:18021073] +synonym: "TAK1 kinase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097077 +name: copper ion sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+)." [GOC:rs, PMID:19928961] +is_a: GO:0005507 ! copper ion binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0097078 +name: FAL1-SGD1 complex +namespace: cellular_component +def: "A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits." [GOC:rb, PMID:21576267] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097079 +name: selenite:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in)." [GOC:mcc, PMID:20861301] +synonym: "selenite:H+ symporter activity" EXACT [] +synonym: "selenite:hydrogen symporter activity" EXACT [] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0097080 +name: plasma membrane selenite transport +namespace: biological_process +def: "The directed movement of inorganic selenite (HSeO3-1 at physiological pH) across a plasma membrane." [GOC:mcc, PMID:20861301] +synonym: "plasma membrane hydrogenselenite transport" EXACT [] +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0097081 +name: vascular associated smooth muscle cell fate commitment +namespace: biological_process +def: "The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate commitment" EXACT [] +is_a: GO:0042693 ! muscle cell fate commitment +relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:0097082 +name: vascular associated smooth muscle cell fate specification +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate specification" EXACT [] +is_a: GO:0042694 ! muscle cell fate specification +relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment + +[Term] +id: GO:0097083 +name: vascular associated smooth muscle cell fate determination +namespace: biological_process +def: "The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell fate determination" EXACT [] +is_a: GO:0007521 ! muscle cell fate determination +relationship: part_of GO:0097081 ! vascular associated smooth muscle cell fate commitment + +[Term] +id: GO:0097084 +name: vascular associated smooth muscle cell development +namespace: biological_process +def: "The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [GOC:BHF] +synonym: "vascular smooth muscle cell development" EXACT [] +is_a: GO:0055001 ! muscle cell development +relationship: part_of GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:0097085 +name: interferon regulatory factor 3-interferon regulatory factor 5 complex +namespace: cellular_component +def: "An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5." [GOC:cna, PMID:12138184] +synonym: "IRF3:IRF5 complex" EXACT [] +is_a: GO:0097071 ! interferon regulatory factor complex + +[Term] +id: GO:0097086 +name: amniotic stem cell differentiation +namespace: biological_process +def: "The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone." [CL:0002639, GOC:yaf, PMID:20942606, Wikipedia:Amniotic_stem_cells] +is_a: GO:0072497 ! mesenchymal stem cell differentiation + +[Term] +id: GO:0097087 +name: interleukin-17A production +namespace: biological_process +alt_id: GO:0150154 +def: "The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PMID:27901018] +subset: gocheck_do_not_annotate +synonym: "IL-17A production" EXACT [] +synonym: "interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0097088 +name: interleukin-17F production +namespace: biological_process +def: "The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, Wikipedia:Interleukin_17] +subset: gocheck_do_not_annotate +synonym: "IL-17F production" EXACT [] +is_a: GO:0032620 ! interleukin-17 production + +[Term] +id: GO:0097089 +name: methyl-branched fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain." [GOC:rs, PMID:19933331] +synonym: "methyl-branched fatty acid metabolism" EXACT [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006629 ! lipid metabolic process + +[Term] +id: GO:0097090 +name: presynaptic membrane organization +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:19730411] +comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. +synonym: "pre-synaptic membrane organization" EXACT [] +synonym: "presynaptic membrane organisation" EXACT [] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0097091 +name: synaptic vesicle clustering +namespace: biological_process +def: "The process that results in grouping synaptic vesicles in presynaptic structures." [GOC:ans, GOC:pr, PMID:19900895, PMID:7568108] +subset: goslim_synapse +is_a: GO:0097479 ! synaptic vesicle localization +relationship: part_of GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0097092 +name: polyacyltrehalose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [GOC:rs, PMID:19729090] +synonym: "polyacyltrehalose metabolism" EXACT [] +is_a: GO:0006664 ! glycolipid metabolic process + +[Term] +id: GO:0097093 +name: polyacyltrehalose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid." [GOC:rs, PMID:19729090] +synonym: "polyacyltrehalose anabolism" EXACT [] +synonym: "polyacyltrehalose biosynthesis" EXACT [] +synonym: "polyacyltrehalose formation" EXACT [] +synonym: "polyacyltrehalose synthesis" EXACT [] +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:0097092 ! polyacyltrehalose metabolic process + +[Term] +id: GO:0097094 +name: craniofacial suture morphogenesis +namespace: biological_process +def: "The process in which any suture between cranial and/or facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0060349 ! bone morphogenesis +relationship: part_of GO:1904888 ! cranial skeletal system development + +[Term] +id: GO:0097095 +name: frontonasal suture morphogenesis +namespace: biological_process +def: "The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized." [GOC:pr, GOC:sl, PMID:12416537, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] +synonym: "nasofrontal suture morphogenesis" EXACT [] +is_a: GO:0097094 ! craniofacial suture morphogenesis + +[Term] +id: GO:0097096 +name: facial suture morphogenesis +namespace: biological_process +def: "The process in which any suture between facial bones is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] +is_a: GO:0097094 ! craniofacial suture morphogenesis + +[Term] +id: GO:0097097 +name: nasal suture morphogenesis +namespace: biological_process +def: "The process in which the nasal suture is generated and organized." [GOC:pr, GOC:sl, Wikipedia:Cranial_sutures, Wikipedia:Head_and_neck_anatomy#Musculoskeletal_system] +synonym: "internasal suture morphogenesis" EXACT [] +is_a: GO:0097096 ! facial suture morphogenesis + +[Term] +id: GO:0097098 +name: DNA/RNA hybrid annealing activity +namespace: molecular_function +def: "An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops." [GOC:imk, PMID:21699496] +is_a: GO:0071667 ! DNA/RNA hybrid binding +is_a: GO:0140666 ! annealing activity + +[Term] +id: GO:0097099 +name: structural constituent of albumen +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo." [GOC:jj, Wikipedia:Albumen] +synonym: "structural constituent of egg white" EXACT [] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0097100 +name: supercoiled DNA binding +namespace: molecular_function +def: "Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA." [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil] +is_a: GO:0003690 ! double-stranded DNA binding + +[Term] +id: GO:0097101 +name: blood vessel endothelial cell fate specification +namespace: biological_process +def: "The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels." [CL:0002139, GOC:dgh, PMID:21521739] +is_a: GO:0060847 ! endothelial cell fate specification +relationship: part_of GO:0060846 ! blood vessel endothelial cell fate commitment + +[Term] +id: GO:0097102 +name: endothelial tip cell fate specification +namespace: biological_process +def: "The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels." [CL:0000704, GOC:dgh, PMID:21521739] +synonym: "angiogenic tip cell fate specification" EXACT [] +is_a: GO:0097101 ! blood vessel endothelial cell fate specification +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0097103 +name: endothelial stalk cell fate specification +namespace: biological_process +def: "The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout." [CL:0002671, GOC:dgh, PMID:21521739] +synonym: "angiogenic stalk cell fate specification" EXACT [] +is_a: GO:0097101 ! blood vessel endothelial cell fate specification +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0097104 +name: postsynaptic membrane assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:BHF, GOC:sjp, PMID:21424692] +subset: goslim_synapse +synonym: "post-synaptic membrane assembly" EXACT [] +is_a: GO:0001941 ! postsynaptic membrane organization +is_a: GO:0071709 ! membrane assembly +relationship: part_of GO:0099068 ! postsynapse assembly + +[Term] +id: GO:0097105 +name: presynaptic membrane assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction." [GOC:BHF, GOC:pr, GOC:sjp, PMID:15797875, PMID:18550748] +comment: Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. +subset: goslim_synapse +synonym: "pre-synaptic membrane assembly" EXACT [] +is_a: GO:0071709 ! membrane assembly +is_a: GO:0097090 ! presynaptic membrane organization +relationship: part_of GO:0099054 ! presynapse assembly + +[Term] +id: GO:0097106 +name: postsynaptic density organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] +synonym: "post synaptic density organization" EXACT [] +synonym: "post-synaptic density organization" EXACT [] +synonym: "postsynaptic density organisation" EXACT [] +synonym: "PSD organization" EXACT [] +is_a: GO:0099084 ! postsynaptic specialization organization + +[Term] +id: GO:0097107 +name: postsynaptic density assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse." [GOC:BHF, GOC:sjp, PMID:21525273] +subset: goslim_synapse +synonym: "post synaptic density assembly" EXACT [] +synonym: "post-synaptic density assembly" EXACT [] +synonym: "PSD assembly" EXACT [] +is_a: GO:0097106 ! postsynaptic density organization +is_a: GO:0098698 ! postsynaptic specialization assembly +relationship: part_of GO:1904861 ! excitatory synapse assembly + +[Term] +id: GO:0097108 +name: hedgehog family protein binding +namespace: molecular_function +def: "Binding to a member of the hedgehog protein family, signaling proteins involved in development." [GOC:BHF, GOC:pr, PMID:10050855] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097109 +name: neuroligin family protein binding +namespace: molecular_function +def: "Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation." [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:0097110 +name: scaffold protein binding +namespace: molecular_function +def: "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes." [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097111 +name: endoplasmic reticulum-Golgi intermediate compartment organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment." [GOC:br, PMID:18287528] +synonym: "endoplasmic reticulum-Golgi intermediate compartment organisation" EXACT [] +synonym: "endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis" RELATED [] +synonym: "ER-Golgi intermediate compartment organization" EXACT [] +synonym: "ERGIC organization" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0097112 +name: gamma-aminobutyric acid receptor clustering +namespace: biological_process +def: "The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359] +synonym: "GABA receptor clustering" EXACT [] +is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering +relationship: part_of GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:0097113 +name: AMPA glutamate receptor clustering +namespace: biological_process +def: "The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:pr, GOC:sjp, PMID:12796785] +synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [] +synonym: "AMPA receptor clustering" EXACT [] +is_a: GO:0097688 ! glutamate receptor clustering +relationship: part_of GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:0097114 +name: NMDA glutamate receptor clustering +namespace: biological_process +def: "The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [GOC:BHF, GOC:sjp, PMID:15620359] +synonym: "N-methyl-D-aspartate receptor clustering" EXACT [] +synonym: "NMDA receptor clustering" EXACT [] +is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering +relationship: part_of GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:0097115 +name: neurexin clustering involved in presynaptic membrane assembly +namespace: biological_process +def: "The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals." [GOC:BHF, GOC:sjp, PMID:12796785] +synonym: "neurexin clustering" BROAD [] +synonym: "Nrxn clustering" BROAD [] +synonym: "presynaptic neurexin clustering" EXACT [] +is_a: GO:0043113 ! receptor clustering +relationship: part_of GO:0097105 ! presynaptic membrane assembly + +[Term] +id: GO:0097116 +name: gephyrin clustering involved in postsynaptic density assembly +namespace: biological_process +def: "The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses." [GOC:BHF, GOC:sjp, PMID:15620359, PMID:24552784, PMID:25772192] +synonym: "Geph clustering" BROAD [] +is_a: GO:0035418 ! protein localization to synapse +relationship: part_of GO:0097107 ! postsynaptic density assembly + +[Term] +id: GO:0097117 +name: guanylate kinase-associated protein clustering +namespace: biological_process +def: "The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons." [GOC:BHF, GOC:sjp, PMID:15620359] +synonym: "GKAP clustering" EXACT [] +is_a: GO:0072657 ! protein localization to membrane +relationship: part_of GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:0097118 +name: neuroligin clustering involved in postsynaptic membrane assembly +namespace: biological_process +def: "The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons." [GOC:BHF, GOC:sjp, PMID:12796785] +synonym: "neuroligin clustering" BROAD [] +synonym: "Nlgn clustering" BROAD [] +synonym: "postsynaptic neuroligin clustering" EXACT [] +is_a: GO:0043113 ! receptor clustering +relationship: part_of GO:0097104 ! postsynaptic membrane assembly + +[Term] +id: GO:0097119 +name: postsynaptic density protein 95 clustering +namespace: biological_process +def: "The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins." [GOC:BHF, GOC:sjp, PMID:10433269] +synonym: "Dlg4 clustering" EXACT [] +synonym: "post-synaptic density protein 95 clustering" EXACT [] +synonym: "PSD-95 clustering" EXACT [] +is_a: GO:0072657 ! protein localization to membrane +relationship: part_of GO:0001941 ! postsynaptic membrane organization +relationship: part_of GO:0097106 ! postsynaptic density organization + +[Term] +id: GO:0097120 +name: receptor localization to synapse +namespace: biological_process +def: "Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:BHF, GOC:sjp, PMID:21525273] +synonym: "receptor localisation to synapse" EXACT [] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0097121 +name: cyclin A1-CDK1 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097122 +name: cyclin A2-CDK1 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097123 +name: cyclin A1-CDK2 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097124 +name: cyclin A2-CDK2 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097125 +name: cyclin B1-CDK1 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097126 +name: cyclin B2-CDK1 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097127 +name: cyclin B3-CDK2 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097128 +name: cyclin D1-CDK4 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097129 +name: cyclin D2-CDK4 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097130 +name: cyclin D3-CDK4 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097131 +name: cyclin D1-CDK6 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097132 +name: cyclin D2-CDK6 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097133 +name: cyclin D3-CDK6 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097134 +name: cyclin E1-CDK2 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097135 +name: cyclin E2-CDK2 complex +namespace: cellular_component +def: "A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [GOC:so, PMID:15935619] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:0097136 +name: Bcl-2 family protein complex +namespace: cellular_component +def: "A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed." [GOC:so, PMID:14634621] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097137 +name: BAD-BCL-xl complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097138 +name: BAD-BCL-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097139 +name: BID-BCL-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097140 +name: BIM-BCL-xl complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097141 +name: BIM-BCL-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097142 +name: PUMA-BCL-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097143 +name: PUMA-BCL-xl complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097144 +name: BAX complex +namespace: cellular_component +def: "An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097145 +name: BAK complex +namespace: cellular_component +def: "An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097146 +name: NOXA-BCL-xl complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097147 +name: NOXA-BCL-2 complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097148 +name: BCL-2 complex +namespace: cellular_component +def: "A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, GOC:so, PMID:14634621] +is_a: GO:0097136 ! Bcl-2 family protein complex + +[Term] +id: GO:0097149 +name: centralspindlin complex +namespace: cellular_component +def: "A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals)." [GOC:ans, PMID:11782313, PMID:16236794] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0072686 ! mitotic spindle + +[Term] +id: GO:0097150 +name: neuronal stem cell population maintenance +namespace: biological_process +def: "Any process in by an organism or tissue maintains a population of neuronal stem cells." [CL:0000047, GOC:dos, GOC:yaf, PMID:11399758] +is_a: GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:0097151 +name: positive regulation of inhibitory postsynaptic potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:BHF, GOC:sjp, PMID:18550748] +synonym: "positive regulation of inhibitory post-synaptic membrane potential" EXACT [] +synonym: "positive regulation of IPSP" EXACT [] +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:0098828 ! modulation of inhibitory postsynaptic potential +relationship: positively_regulates GO:0060080 ! inhibitory postsynaptic potential + +[Term] +id: GO:0097152 +name: mesenchymal cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [CL:0000134, GOC:mtg_apoptosis, GOC:yaf, PMID:18231833] +synonym: "mesenchymal cell apoptosis" NARROW [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0097153 +name: cysteine-type endopeptidase activity involved in apoptotic process +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process." [GOC:mtg_apoptosis] +synonym: "caspase activity" BROAD [] +synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] +xref: Reactome:R-HSA-6800797 "The PIDDosome activates CASP2" +is_a: GO:0004197 ! cysteine-type endopeptidase activity + +[Term] +id: GO:0097154 +name: GABAergic neuron differentiation +namespace: biological_process +def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron." [GOC:kmv, PMID:11517269] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:0097155 +name: fasciculation of sensory neuron axon +namespace: biological_process +def: "The collection of sensory neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711] +is_a: GO:0007413 ! axonal fasciculation + +[Term] +id: GO:0097156 +name: fasciculation of motor neuron axon +namespace: biological_process +def: "The collection of motor neuron axons into a bundle of rods, known as a fascicle." [GOC:lb, PMID:18403711] +is_a: GO:0007413 ! axonal fasciculation + +[Term] +id: GO:0097157 +name: pre-mRNA intronic binding +namespace: molecular_function +def: "Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624] +synonym: "pre-messenger RNA intronic binding" EXACT [] +is_a: GO:0036002 ! pre-mRNA binding + +[Term] +id: GO:0097158 +name: pre-mRNA intronic pyrimidine-rich binding +namespace: molecular_function +def: "Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA)." [GOC:ans, PMID:16260624, PMID:16777844] +synonym: "pre-messenger RNA intronic pyrimidine-rich binding" EXACT [] +is_a: GO:0097157 ! pre-mRNA intronic binding + +[Term] +id: GO:0097159 +name: organic cyclic compound binding +namespace: molecular_function +def: "Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [GOC:sjw, PMID:7583672] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0097160 +name: polychlorinated biphenyl binding +namespace: molecular_function +def: "Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings." [GOC:sjw, PMID:7583672] +synonym: "PCB binding" EXACT [] +synonym: "polychlorobiphenyl binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:0097161 +name: DH domain binding +namespace: molecular_function +def: "Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket." [GOC:yaf, InterPro:IPR000219, PMID:12775584] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0097162 +name: MADS box domain binding +namespace: molecular_function +def: "Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs." [GOC:yaf, InterPro:IPR002100, PMID:18296735, Wikipedia:MADS-box] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0097163 +name: sulfur carrier activity +namespace: molecular_function +def: "Covalently binding to sulfur and delivering it to an acceptor molecule." [GOC:imk, PMID:16387657] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0097164 +name: ammonium ion metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the ammonium ion." [GOC:dhl, GOC:tb, PMID:14671018] +synonym: "ammonium ion metabolism" EXACT [] +synonym: "ammonium metabolic process" RELATED [] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:0097165 +name: nuclear stress granule +namespace: cellular_component +def: "A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:10359787, PMID:12865437] +is_a: GO:0035770 ! ribonucleoprotein granule +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0097166 +name: lens epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth." [CL:0002224, GOC:yaf, PMID:18423449, Wikipedia:Lens_%28anatomy%29#Lens_epithelium] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0002088 ! lens development in camera-type eye + +[Term] +id: GO:0097167 +name: circadian regulation of translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours." [GOC:ans, PMID:17264215] +synonym: "regulation of mRNA translation in response to circadian clock" EXACT [] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0007623 ! circadian rhythm +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0097168 +name: mesenchymal stem cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." [CL:0000134, GOC:yaf, PMID:20626275] +synonym: "MSC proliferation" EXACT [] +is_a: GO:0072089 ! stem cell proliferation + +[Term] +id: GO:0097169 +name: AIM2 inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA." [GOC:vp, PMID:20303873] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0097170 +name: ADP-L-glycero-beta-D-manno-heptose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [GOC:yaf] +synonym: "ADP-L-glycero-beta-D-manno-heptose metabolism" EXACT [] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:0097171 +name: ADP-L-glycero-beta-D-manno-heptose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate." [GOC:yaf, UniPathway:UPA00356] +synonym: "ADP-L-glycero-beta-D-manno-heptose anabolism" EXACT [] +synonym: "ADP-L-glycero-beta-D-manno-heptose biosynthesis" EXACT [] +synonym: "ADP-L-glycero-beta-D-manno-heptose formation" EXACT [] +synonym: "ADP-L-glycero-beta-D-manno-heptose synthesis" EXACT [] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0097170 ! ADP-L-glycero-beta-D-manno-heptose metabolic process + +[Term] +id: GO:0097172 +name: N-acetylmuramic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [GOC:yaf] +synonym: "N-acetylmuramate metabolic process" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramate metabolism" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramic acid metabolism" EXACT [PubChem_Compound:5462244] +is_a: GO:0019752 ! carboxylic acid metabolic process + +[Term] +id: GO:0097173 +name: N-acetylmuramic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine." [GOC:yaf, UniPathway:UPA00342] +synonym: "N-acetylmuramate breakdown" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramate catabolic process" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramate catabolism" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramate degradation" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramic acid breakdown" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramic acid catabolism" EXACT [PubChem_Compound:5462244] +synonym: "N-acetylmuramic acid degradation" EXACT [PubChem_Compound:5462244] +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:0097172 ! N-acetylmuramic acid metabolic process + +[Term] +id: GO:0097174 +name: 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [GOC:yaf, PMID:15901686] +synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolic process" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramate metabolism" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramic acid metabolism" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid metabolic process" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid metabolism" EXACT [] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:0097175 +name: 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid." [GOC:yaf, PMID:15901686, UniPathway:UPA00343] +synonym: "1,6-anhydro-N-acetyl-beta-muramate breakdown" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolic process" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramate catabolism" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramate degradation" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramic acid breakdown" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramic acid catabolism" EXACT [] +synonym: "1,6-anhydro-N-acetyl-beta-muramic acid degradation" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramate breakdown" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramate catabolic process" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramate catabolism" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramate degradation" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid breakdown" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid catabolic process" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid catabolism" EXACT [] +synonym: "1,6-anhydro-N-acetylmuramic acid degradation" EXACT [] +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0097174 ! 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process + +[Term] +id: GO:0097176 +name: epoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers." [GOC:rs, PMID:15822179] +synonym: "epoxide metabolism" EXACT [] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0097177 +name: mitochondrial ribosome binding +namespace: molecular_function +def: "Binding to a mitochondrial ribosome." [GOC:ans, PMID:20739282] +is_a: GO:0043022 ! ribosome binding + +[Term] +id: GO:0097178 +name: ruffle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42." [GOC:yaf, http:en.wikipedia.org/wiki/Membrane_ruffling, PMID:12556481] +synonym: "membrane ruffle formation" EXACT [] +synonym: "membrane ruffling" EXACT [] +is_a: GO:0031529 ! ruffle organization +is_a: GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0097179 +name: protease inhibitor complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity." [GOC:ans, PMID:6323392] +synonym: "peptidase inhibitor complex" BROAD [] +is_a: GO:1904090 ! peptidase inhibitor complex + +[Term] +id: GO:0097180 +name: serine protease inhibitor complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity." [GOC:ans, PMID:6323392] +synonym: "serine-type endopeptidase inhibitor complex" EXACT [GOC:bf, GOC:pr] +synonym: "serpin complex" EXACT [] +is_a: GO:0097179 ! protease inhibitor complex + +[Term] +id: GO:0097181 +name: protein C inhibitor-coagulation factor V complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V." [GOC:ans, PMID:6323392] +synonym: "PCI-coagulation factor V complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-coagulation factor V complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-F5 complex" EXACT [PR:000007300] +synonym: "serpin A5-coagulation factor V complex" EXACT [PR:000014685] +synonym: "SERPINA5-coagulation factor V complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0097182 +name: protein C inhibitor-coagulation factor Xa complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa." [GOC:ans, PMID:6323392] +synonym: "PCI-coagulation factor Xa complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-coagulation factor Xa complex" EXACT [PR:000014685] +synonym: "serpin A5-coagulation factor Xa complex" EXACT [PR:000014685] +synonym: "SERPINA5-coagulation factor Xa complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0097183 +name: protein C inhibitor-coagulation factor XI complex +namespace: cellular_component +def: "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI." [GOC:ans, PMID:2844223] +synonym: "PCI-coagulation factor XI complex" EXACT [PR:000014685] +synonym: "plasma serine protease inhibitor-coagulation factor XI complex" EXACT [PR:000014685] +synonym: "protein C inhibitor-F11 complex" EXACT [PR:000007295] +synonym: "serpin A5-coagulation factor XI complex" EXACT [PR:000014685] +synonym: "SERPINA5-coagulation factor XI complex" EXACT [PR:000014685] +is_a: GO:0097180 ! serine protease inhibitor complex + +[Term] +id: GO:0097184 +name: response to azide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [GOC:yaf, PMID:16846222] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:0097185 +name: cellular response to azide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus." [GOC:yaf, PMID:16846222] +is_a: GO:0071241 ! cellular response to inorganic substance +is_a: GO:0097184 ! response to azide +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:0097186 +name: amelogenesis +namespace: biological_process +def: "The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] +synonym: "enamel development" EXACT [] +is_a: GO:0042475 ! odontogenesis of dentin-containing tooth +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0097187 +name: dentinogenesis +namespace: biological_process +def: "The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." [GOC:cjm, GOC:sl, PMID:10206335, PMID:21196346] +synonym: "dentin development" EXACT [] +synonym: "dentine development" EXACT [] +is_a: GO:0042475 ! odontogenesis of dentin-containing tooth +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:0097188 +name: dentin mineralization +namespace: biological_process +def: "The process in which calcium salts are deposited into the calcareous tooth structure known as dentin." [GOC:sl, PMID:10206335, PMID:21196346] +synonym: "dentine mineralization" EXACT [] +is_a: GO:0034505 ! tooth mineralization +relationship: part_of GO:0097187 ! dentinogenesis + +[Term] +id: GO:0097189 +name: apoptotic body +namespace: cellular_component +def: "A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um." [GOC:mtg_apoptosis, GOC:vesicles, PMID:15242875, PMID:24223256, Wikipedia:Apoptosis, Wikipedia:Bleb_(cell_biology)] +synonym: "apoptotic bleb" RELATED [GOC:vesicles] +synonym: "apoptotic vesicle" EXACT [GOC:vesicles] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:0097190 +name: apoptotic signaling pathway +namespace: biological_process +alt_id: GO:0008624 +def: "A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis] +comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. +synonym: "apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "induction of apoptosis by extracellular signals" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0006915 ! apoptotic process + +[Term] +id: GO:0097191 +name: extrinsic apoptotic signaling pathway +namespace: biological_process +def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, GOC:yaf, PMID:17340152] +comment: Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. +synonym: "death receptor-mediated apoptosis" NARROW [] +synonym: "extrinsic apoptosis" NARROW [] +synonym: "extrinsic apoptotic pathway" EXACT [] +synonym: "extrinsic apoptotic signaling pathway in presence of ligand" NARROW [] +synonym: "extrinsic apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:0007166 ! cell surface receptor signaling pathway +is_a: GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0097192 +name: extrinsic apoptotic signaling pathway in absence of ligand +namespace: biological_process +def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] +comment: For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154). +synonym: "dependence receptor signaling pathway" RELATED [] +synonym: "extrinsic apoptosis in absence of ligand" NARROW [] +synonym: "extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] +is_a: GO:0038034 ! signal transduction in absence of ligand +is_a: GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:0097193 +name: intrinsic apoptotic signaling pathway +namespace: biological_process +alt_id: GO:0008629 +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] +comment: The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595. +synonym: "induction of apoptosis by intracellular signals" RELATED [] +synonym: "intrinsic apoptosis" NARROW [] +synonym: "intrinsic apoptotic pathway" EXACT [] +synonym: "intrinsic apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "mitochondrial-mediated apoptotic pathway" EXACT [] +is_a: GO:0035556 ! intracellular signal transduction +is_a: GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0097194 +name: execution phase of apoptosis +namespace: biological_process +def: "A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:mtg_apoptosis, PMID:21760595] +synonym: "apoptosis" NARROW [] +synonym: "execution phase of apoptotic process" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0006915 ! apoptotic process + +[Term] +id: GO:0097195 +name: pilomotor reflex +namespace: biological_process +def: "The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect." [GOC:BHF, PMID:21335239, Wikipedia:Pilomotor_reflex] +synonym: "goosebump reflex" EXACT [] +synonym: "horripilation" EXACT [] +synonym: "piloerection" EXACT [] +is_a: GO:0060004 ! reflex + +[Term] +id: GO:0097196 +name: Shu complex +namespace: cellular_component +def: "A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p." [GOC:jh, PMID:15654096, PMID:19496932] +is_a: GO:1990391 ! DNA repair complex + +[Term] +id: GO:0097197 +name: tetraspanin-enriched microdomain +namespace: cellular_component +def: "A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities." [GOC:ans, PMID:19709882, PMID:21930792] +synonym: "membrane tetraspanin-enriched microdomain" EXACT [] +synonym: "TEM" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0097198 +name: histone H3-K36 trimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone." [GOC:se, PMID:17948059] +is_a: GO:0010452 ! histone H3-K36 methylation +is_a: GO:0018023 ! peptidyl-lysine trimethylation + +[Term] +id: GO:0097199 +name: cysteine-type endopeptidase activity involved in apoptotic signaling pathway +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway." [GOC:mtg_apoptosis, PMID:11717445, Wikipedia:Caspase] +comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases. +synonym: "activator caspase activity" NARROW [] +synonym: "apical caspase activity" NARROW [] +synonym: "cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "initiator caspase activity" NARROW [] +is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:0097200 +name: cysteine-type endopeptidase activity involved in execution phase of apoptosis +namespace: molecular_function +def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis." [GOC:mtg_apoptosis, Wikipedia:Caspase] +comment: Examples of gene products that may be annotated to this term include CASP3, CASP6 and CASP7, also called effector (or executioner) caspases. +synonym: "effector caspase activity" NARROW [] +synonym: "executioner caspase activity" NARROW [] +is_a: GO:0097153 ! cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:0097201 +name: negative regulation of transcription from RNA polymerase II promoter in response to stress +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:rn, PMID:11027285, PMID:15575969, PMID:16556235, PMID:18086556, PMID:18627600] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:0097202 +name: activation of cysteine-type endopeptidase activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:21726810] +comment: This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919. +synonym: "activation of caspase activity" NARROW [] +synonym: "activation of metacaspase activity" RELATED [] +is_a: GO:0031638 ! zymogen activation +is_a: GO:2001056 ! positive regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:0097203 +name: phagocytic cup lip +namespace: cellular_component +def: "The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome." [GOC:pf, PMID:20200225] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0001891 ! phagocytic cup + +[Term] +id: GO:0097204 +name: phagocytic cup base +namespace: cellular_component +def: "The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking." [GOC:pf, PMID:20200225] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0001891 ! phagocytic cup + +[Term] +id: GO:0097205 +name: renal filtration +namespace: biological_process +def: "A renal system process in which fluid circulating through the body is filtered through a barrier system." [GOC:pr, GOC:sart] +is_a: GO:0003014 ! renal system process + +[Term] +id: GO:0097206 +name: nephrocyte filtration +namespace: biological_process +def: "The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm." [GOC:sart, PMID:18971929] +is_a: GO:0097205 ! renal filtration + +[Term] +id: GO:0097207 +name: bud dormancy process +namespace: biological_process +def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud." [GOC:PO_curators, PO_REF:00009] +comment: Bud dormancy may precede dormancy of the whole plant. +synonym: "bud dormancy" RELATED [] +is_a: GO:0022611 ! dormancy process +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0097208 +name: alveolar lamellar body +namespace: cellular_component +def: "A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:cjm, Wikipedia:Lamellar_granule] +is_a: GO:0042599 ! lamellar body + +[Term] +id: GO:0097209 +name: epidermal lamellar body +namespace: cellular_component +def: "A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:cjm, Wikipedia:Lamellar_granule] +is_a: GO:0042599 ! lamellar body + +[Term] +id: GO:0097210 +name: response to gonadotropin-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007] +synonym: "response to GnRH" EXACT [] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:0097211 +name: cellular response to gonadotropin-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:yaf, PMID:15976007] +synonym: "cellular response to GnRH" EXACT [] +synonym: "cellular response to gonadotrophin-releasing hormone" EXACT [GOC:dph] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:0097210 ! response to gonadotropin-releasing hormone + +[Term] +id: GO:0097212 +name: lysosomal membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:yaf, PMID:20544854] +synonym: "lysosomal membrane organisation" EXACT [GOC:mah] +synonym: "lysosome membrane organization" EXACT [] +is_a: GO:0061024 ! membrane organization +relationship: part_of GO:0007040 ! lysosome organization + +[Term] +id: GO:0097213 +name: regulation of lysosomal membrane permeability +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] +synonym: "regulation of lysosome membrane permeability" EXACT [] +is_a: GO:0090559 ! regulation of membrane permeability +is_a: GO:0097212 ! lysosomal membrane organization + +[Term] +id: GO:0097214 +name: positive regulation of lysosomal membrane permeability +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] +synonym: "positive regulation of lysosome membrane permeability" EXACT [] +is_a: GO:0097213 ! regulation of lysosomal membrane permeability +is_a: GO:1905710 ! positive regulation of membrane permeability + +[Term] +id: GO:0097215 +name: negative regulation of lysosomal membrane permeability +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane." [GOC:yaf, PMID:20544854] +synonym: "negative regulation of lysosome membrane permeability" EXACT [] +is_a: GO:0097213 ! regulation of lysosomal membrane permeability +is_a: GO:1905709 ! negative regulation of membrane permeability + +[Term] +id: GO:0097216 +name: guanosine tetraphosphate binding +namespace: molecular_function +def: "Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions." [GOC:imk, PMID:15109491, PMID:16968770, PMID:18359660] +synonym: "5'-ppGpp-3' binding" EXACT [] +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0097217 +name: sieve area +namespace: cellular_component +def: "A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements." [ISBN:0471738433, POC:curators] +comment: Part of a sieve element (PO:0025406). +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009505 ! plant-type cell wall + +[Term] +id: GO:0097218 +name: sieve plate +namespace: cellular_component +def: "A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas." [ISBN:0471738433, POC:curators] +comment: Typical of angiosperms. Part of sieve tube member (PO:0000289). +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009505 ! plant-type cell wall + +[Term] +id: GO:0097219 +name: compound sieve plate +namespace: cellular_component +def: "A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement." [ISBN:0471738433, POC:curators] +comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. +is_a: GO:0097218 ! sieve plate + +[Term] +id: GO:0097220 +name: simple sieve plate +namespace: cellular_component +def: "A sieve plate that contains a single specialized sieve area." [ISBN:0471738433, POC:curators] +comment: Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. +is_a: GO:0097218 ! sieve plate + +[Term] +id: GO:0097221 +name: M/G1 phase-specific MADS box-forkhead transcription factor complex +namespace: cellular_component +def: "A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2." [GOC:mah, PMID:18057023] +synonym: "PBF complex" NARROW [] +synonym: "PBF transcription complex" NARROW [GOC:vw] +synonym: "PCB binding factor complex" NARROW [] +synonym: "pombe cell cycle box binding factor complex" NARROW [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0097222 +name: mitochondrial mRNA polyadenylation +namespace: biological_process +def: "The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails." [GOC:ans, PMID:18083837] +is_a: GO:0006378 ! mRNA polyadenylation +is_a: GO:0090616 ! mitochondrial mRNA 3'-end processing + +[Term] +id: GO:0097223 +name: obsolete sperm part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cjm] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +is_obsolete: true +consider: CL:0000019 + +[Term] +id: GO:0097224 +name: sperm connecting piece +namespace: cellular_component +def: "The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum." [GOC:cjm, MP:0009830] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097225 +name: sperm midpiece +namespace: cellular_component +def: "The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece." [GOC:cjm, MP:0009831] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097226 +name: sperm mitochondrial sheath +namespace: cellular_component +def: "The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:cjm, MP:0009832] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097227 +name: sperm annulus +namespace: cellular_component +def: "The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity." [GOC:cjm, MP:0009834] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097228 +name: sperm principal piece +namespace: cellular_component +def: "The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece." [GOC:cjm, MP:0009836] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097229 +name: sperm end piece +namespace: cellular_component +def: "The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane." [GOC:cjm, GOC:sart, MP:0009837] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0036126 ! sperm flagellum + +[Term] +id: GO:0097230 +name: cell motility in response to potassium ion +namespace: biological_process +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624] +synonym: "K+ facilitation of cell motility" EXACT [] +synonym: "potassium ion facilitation of cell motility" EXACT [] +is_a: GO:0048870 ! cell motility +relationship: part_of GO:0035865 ! cellular response to potassium ion + +[Term] +id: GO:0097231 +name: cell motility in response to calcium ion +namespace: biological_process +def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus." [GOC:pf, PMID:19363786, PMID:21239624, PMID:8937985] +synonym: "Ca2+ facilitation of cell motility" EXACT [] +synonym: "calcium ion facilitation of cell motility" EXACT [] +is_a: GO:0048870 ! cell motility +relationship: part_of GO:0071277 ! cellular response to calcium ion + +[Term] +id: GO:0097232 +name: lamellar body membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:sl, PMID:11940594] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0042599 ! lamellar body + +[Term] +id: GO:0097233 +name: alveolar lamellar body membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant." [GOC:sl, PMID:11940594] +is_a: GO:0097232 ! lamellar body membrane +relationship: part_of GO:0097208 ! alveolar lamellar body + +[Term] +id: GO:0097234 +name: epidermal lamellar body membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function." [GOC:sl, PMID:11940594] +is_a: GO:0097232 ! lamellar body membrane +relationship: part_of GO:0097209 ! epidermal lamellar body + +[Term] +id: GO:0097235 +name: obsolete positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:1899286] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0097236 +name: obsolete positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of zinc ions." [GOC:dgf, PMID:19702872] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0034224 +consider: GO:0045944 + +[Term] +id: GO:0097237 +name: cellular response to toxic substance +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:pr] +is_a: GO:0009636 ! response to toxic substance +is_a: GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:0097238 +name: cellular response to methylglyoxal +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:pr] +is_a: GO:0051595 ! response to methylglyoxal +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0110096 ! cellular response to aldehyde +is_a: GO:1901655 ! cellular response to ketone + +[Term] +id: GO:0097239 +name: positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus." [GOC:dgf, PMID:15773992] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0097238 ! cellular response to methylglyoxal + +[Term] +id: GO:0097240 +name: chromosome attachment to the nuclear envelope +namespace: biological_process +def: "The process in which chromatin is anchored to the nuclear envelope." [GOC:vw, PMID:31635174] +synonym: "attachment of chromatin to nuclear envelope" RELATED [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0050000 ! chromosome localization + +[Term] +id: GO:0097241 +name: hematopoietic stem cell migration to bone marrow +namespace: biological_process +def: "The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system." [CL:0000037, GOC:yaf, PMID:17368745] +synonym: "hematopoietic stem cell homing" BROAD [] +synonym: "hemopoietic stem cell migration to bone marrow" EXACT [] +synonym: "progenitor cell homing" BROAD [] +is_a: GO:0035701 ! hematopoietic stem cell migration + +[Term] +id: GO:0097242 +name: amyloid-beta clearance +namespace: biological_process +def: "The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors." [GOC:aruk, GOC:bc, GOC:BHF, PMID:18289866, PMID:19098903, PMID:26005850] +synonym: "beta-amyloid clearance" EXACT [] +is_a: GO:0032501 ! multicellular organismal process + +[Term] +id: GO:0097243 +name: flavonoid binding +namespace: molecular_function +def: "Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge." [GOC:sl, PMID:20599706] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0097244 +name: flavonol binding +namespace: molecular_function +def: "Binding to a flavonol, a flavonoid that contains a 3-hydroxy-2-phenylchromen-4-one backbone." [GOC:sl] +is_a: GO:0043168 ! anion binding +is_a: GO:0097243 ! flavonoid binding + +[Term] +id: GO:0097245 +name: flavanol binding +namespace: molecular_function +def: "Binding to a flavanol." [GOC:sl] +synonym: "flavan-3-ol binding" NARROW [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:0097243 ! flavonoid binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0097246 +name: catechin binding +namespace: molecular_function +def: "Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure." [GOC:sl] +is_a: GO:0097245 ! flavanol binding + +[Term] +id: GO:0097247 +name: epigallocatechin 3-gallate binding +namespace: molecular_function +def: "Binding to epigallocatechin 3-gallate, a compound that is a gallic acid ester of a catechin." [GOC:sl, PMID:21307292] +synonym: "catechin gallate binding" BROAD [] +synonym: "EGCG binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:0097243 ! flavonoid binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0097248 +name: maintenance of protein location in cell cortex of cell tip +namespace: biological_process +def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell." [GOC:al, PMID:19646873] +is_a: GO:0032065 ! maintenance of protein location in cell cortex + +[Term] +id: GO:0097250 +name: mitochondrial respirasome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex." [GOC:mcc, PMID:21909073, PMID:22342701] +synonym: "mitochondrial respiratory chain supercomplex assembly" EXACT [] +synonym: "mitochondrial respiratory supercomplex assembly" EXACT [] +is_a: GO:0007005 ! mitochondrion organization +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0097251 +name: leukotriene B4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [GOC:yaf, UniPathway:UPA00878] +synonym: "leukotriene B4 anabolism" EXACT [] +synonym: "leukotriene B4 biosynthesis" EXACT [] +synonym: "leukotriene B4 formation" EXACT [] +synonym: "leukotriene B4 synthesis" EXACT [] +synonym: "LTB4 anabolism" EXACT [] +synonym: "LTB4 biosynthesis" EXACT [] +synonym: "LTB4 formation" EXACT [] +synonym: "LTB4 synthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0019370 ! leukotriene biosynthetic process +is_a: GO:0036102 ! leukotriene B4 metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0097252 +name: oligodendrocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons." [CL:0000128, GOC:mtg_apoptosis, GOC:yaf, PMID:16723520] +synonym: "oligodendrocyte apoptosis" NARROW [] +is_a: GO:0034349 ! glial cell apoptotic process + +[Term] +id: GO:0097253 +name: beta-hydroxybutyrate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid." [GOC:dsf, PMID:22302940] +synonym: "(R)-3-hydroxybutyrate transmembrane transporter activity" EXACT [] +synonym: "3-hydroxybutanoic acid transmembrane transporter activity" EXACT [] +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015245 ! fatty acid transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity + +[Term] +id: GO:0097254 +name: renal tubular secretion +namespace: biological_process +def: "The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs." [GOC:rph, PMID:25287933, Wikipedia:Renal_secretion#Secretion] +is_a: GO:0003014 ! renal system process +is_a: GO:0007588 ! excretion + +[Term] +id: GO:0097255 +name: R2TP complex +namespace: cellular_component +def: "A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others." [GOC:mcc, PMID:15766533, PMID:21925213] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097256 +name: phenyllactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH." [GOC:pde, PMID:10849007, RHEA:38351] +comment: This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU). +xref: RHEA:38351 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0097257 +name: leukotriene B4 12-hydroxy dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)." [GOC:mw, KEGG_REACTION:R03864, PMID:8394361, PMID:9461497] +synonym: "leukotriene B4 12-hydroxydehydrogenase activity" EXACT [] +xref: Reactome:R-HSA-2161567 "LTB4 is oxidised to 12-oxoLTB4 by PTGR1" +xref: RHEA:50608 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0097258 +name: 20-hydroxy-leukotriene B4 omega oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]." [GOC:mw, PMID:2836406, PMID:9675028, RHEA:48668] +synonym: "20-hydroxy-leukotriene B4 omega-oxidase activity" EXACT [] +synonym: "20-hydroxy-leukotriene B4 omega-oxidation" RELATED [] +xref: Reactome:R-HSA-2161745 "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3" +xref: RHEA:48668 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0097259 +name: 20-aldehyde-leukotriene B4 20-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [GOC:mw, PMID:2549038, PMID:2836406, PMID:9675028, RHEA:48672] +xref: Reactome:R-HSA-2161792 "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3" +xref: Reactome:R-HSA-2161979 "20cho-LTB4 is oxidised to 20cooh-LTB4 by ALDH" +xref: RHEA:48672 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0097260 +name: eoxin A4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene A4 = eoxin A4." [GOC:mw, PMID:18184802, PMID:18647347] +xref: Reactome:R-HSA-2162019 "LTA4 is converted to EXA4 by ALOX15" +is_a: GO:0016853 ! isomerase activity + +[Term] +id: GO:0097261 +name: eoxin C4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4." [GOC:mw, PMID:18184802, PMID:18647347] +xref: Reactome:R-HSA-2161768 "EXA4 is converted to EXC4 by LTC4S" +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0097262 +name: eoxin D4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid." [GOC:mw, PMID:18184802, PMID:18647347] +xref: Reactome:R-HSA-2161945 "EXC4 is converted to EXD4 by GGT" +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0097263 +name: eoxin E4 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine." [GOC:mw, PMID:18184802, PMID:18647347] +xref: Reactome:R-HSA-2161868 "EXD4 is converted to EXE4 by DPEP" +is_a: GO:0008238 ! exopeptidase activity + +[Term] +id: GO:0097264 +name: self proteolysis +namespace: biological_process +def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [GOC:yaf, PMID:18676612, PMID:19144634] +synonym: "autolysis" BROAD [] +synonym: "self-proteolysis" EXACT [] +is_a: GO:0006508 ! proteolysis + +[Term] +id: GO:0097265 +name: 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-HETE + NADP(+) = 5-oxo-ETE + NADPH + H(+)." [GOC:mw, PMID:1326548] +synonym: "5(S)-HETE dehydrogenase activity" EXACT [] +synonym: "5-HETE dehydrogenase activity" EXACT [] +synonym: "5-hydroxy-eicosatetraenoic acid dehydrogenase activity" EXACT [] +xref: Reactome:R-HSA-2161776 "5S-HETE is oxidised to 5-oxoETE by 5-HEDH" +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0097266 +name: phenylacetyl-CoA 1,2-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+)." [EC:1.14.13.149, GOC:bf, GOC:gk, PMID:20660314, PMID:21247899] +synonym: "phenylacetyl-CoA epoxidase activity" EXACT [GOC:bf] +synonym: "phenylacetyl-CoA monooxygenase activity" RELATED [EC:1.14.13.149] +synonym: "ring 1,2-phenylacetyl-CoA epoxidase activity" RELATED [EC:1.14.13.149] +xref: EC:1.14.13.149 +xref: KEGG_REACTION:R09838 +xref: RHEA:32171 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0097267 +name: omega-hydroxylase P450 pathway +namespace: biological_process +def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation." [GOC:mw, PMID:10681399] +synonym: "P450 omega-hydroxylase pathway" EXACT [] +is_a: GO:0019369 ! arachidonic acid metabolic process + +[Term] +id: GO:0097268 +name: cytoophidium +namespace: cellular_component +def: "A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human." [GOC:mag, PMID:20513629, PMID:21930098, Wikipedia:CTP_synthase#Cytoophidium] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097269 +name: all-trans-decaprenyl-diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate." [GOC:mw, PMID:16262699, RHEA:27802] +synonym: "(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [] +synonym: "2-trans,6-trans-farnesyl diphosphate activity" EXACT [] +xref: EC:2.5.1.91 +xref: Reactome:R-HSA-2162253 "FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer" +xref: RHEA:27802 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0097270 +name: dishabituation +namespace: biological_process +def: "The temporary recovery of response to a stimulus when a novel stimulus is added." [GOC:kmv, PMID:11390637, Wikipedia:Habituation] +is_a: GO:0046958 ! nonassociative learning + +[Term] +id: GO:0097271 +name: protein localization to bud neck +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location within a cellular bud neck." [GOC:rb, PMID:22344253] +synonym: "protein localisation to bud neck" EXACT [GOC:mah] +synonym: "protein localization to cellular bud neck" EXACT [] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:0097272 +name: ammonium homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of ammonium." [GOC:yaf, PMID:12695560] +synonym: "ammonia homeostasis" EXACT [] +is_a: GO:0055067 ! monovalent inorganic cation homeostasis + +[Term] +id: GO:0097273 +name: creatinine homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of creatinine." [GOC:yaf, PMID:12695560] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0097274 +name: urea homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of urea." [GOC:yaf, PMID:12695560] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:0097275 +name: cellular ammonium homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell." [GOC:yaf, PMID:12695560] +synonym: "cellular ammonia homeostasis" EXACT [] +is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis +is_a: GO:0097272 ! ammonium homeostasis + +[Term] +id: GO:0097276 +name: cellular creatinine homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell." [GOC:yaf, PMID:12695560] +is_a: GO:0055082 ! cellular chemical homeostasis +is_a: GO:0097273 ! creatinine homeostasis + +[Term] +id: GO:0097277 +name: cellular urea homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell." [GOC:yaf, PMID:12695560] +is_a: GO:0055082 ! cellular chemical homeostasis +is_a: GO:0097274 ! urea homeostasis + +[Term] +id: GO:0097278 +name: complement-dependent cytotoxicity +namespace: biological_process +def: "Cell killing caused by the membrane attack complex formed following complement activation." [GOC:add, GOC:rv] +is_a: GO:0001906 ! cell killing + +[Term] +id: GO:0097279 +name: histamine secretion mediated by IgE immunoglobulin +namespace: biological_process +def: "Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen." [GOC:add, GOC:rv] +synonym: "histamine secretion mediated by IgE antibody" EXACT [] +synonym: "Ig-mediated histamine release" BROAD [] +is_a: GO:0097280 ! histamine secretion mediated by immunoglobulin + +[Term] +id: GO:0097280 +name: histamine secretion mediated by immunoglobulin +namespace: biological_process +def: "Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface." [GOC:add, GOC:rv, PMID:11490155, PMID:1719184] +is_a: GO:0002437 ! inflammatory response to antigenic stimulus +is_a: GO:0002441 ! histamine secretion involved in inflammatory response + +[Term] +id: GO:0097281 +name: immune complex formation +namespace: biological_process +def: "The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus." [GOC:add, GOC:rv] +synonym: "antibody-mediated agglutination" EXACT [] +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0097282 +name: immunoglobulin-mediated neutralization +namespace: biological_process +def: "The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin." [GOC:add, GOC:rv] +synonym: "antibody-mediated neutralization" EXACT [] +is_a: GO:0016064 ! immunoglobulin mediated immune response + +[Term] +id: GO:0097283 +name: keratinocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000312, GOC:jc, GOC:mtg_apoptosis, PMID:10201527] +synonym: "keratinocyte apoptosis" NARROW [] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:0097284 +name: hepatocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a hepatocyte, the main structural component of the liver." [CL:0000182, GOC:jc, GOC:mtg_apoptosis, PMID:15856020] +synonym: "hepatocyte apoptosis" NARROW [] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:0097285 +name: obsolete cell-type specific apoptotic process +namespace: biological_process +def: "OBSOLETE. Any apoptotic process in a specific cell type." [GOC:mtg_apoptosis] +comment: This term was made obsolete because it was an unnecessary grouping term. +synonym: "cell-type specific apoptosis" NARROW [] +is_obsolete: true +consider: GO:0006915 + +[Term] +id: GO:0097287 +name: 7-cyano-7-deazaguanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [GOC:yaf, PMID:364423] +synonym: "7-cyano-7-deazaguanine metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0050898 ! nitrile metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:0097288 +name: 7-cyano-7-deazaguanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo." [GOC:yaf, PMID:364423, UniPathway:UPA00391] +synonym: "7-cyano-7-deazaguanine anabolism" EXACT [] +synonym: "7-cyano-7-deazaguanine biosynthesis" EXACT [] +synonym: "7-cyano-7-deazaguanine formation" EXACT [] +synonym: "7-cyano-7-deazaguanine synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0080028 ! nitrile biosynthetic process +is_a: GO:0097287 ! 7-cyano-7-deazaguanine metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0097289 +name: alpha-ribazole metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [GOC:yaf] +synonym: "alpha-ribazole metabolism" EXACT [] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:0097290 +name: alpha-ribazole biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12)." [GOC:yaf, MetaCyc:PWY-5508, MetaCyc:PWY-6269, UniPathway:UPA00061] +synonym: "alpha-ribazole anabolism" EXACT [] +synonym: "alpha-ribazole biosynthesis" EXACT [] +synonym: "alpha-ribazole formation" EXACT [] +synonym: "alpha-ribazole synthesis" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0097289 ! alpha-ribazole metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901659 ! glycosyl compound biosynthetic process + +[Term] +id: GO:0097291 +name: renal phosphate ion absorption +namespace: biological_process +def: "A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:lb, PMID:18784102, PMID:22506049] +synonym: "renal phosphate absorption" EXACT [] +is_a: GO:0070293 ! renal absorption + +[Term] +id: GO:0097292 +name: XMP metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving XMP, xanthosine monophosphate." [GOC:yaf] +synonym: "XMP metabolism" EXACT [] +is_a: GO:0009150 ! purine ribonucleotide metabolic process +is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process + +[Term] +id: GO:0097293 +name: XMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate." [GOC:yaf] +synonym: "XMP anabolism" EXACT [] +synonym: "XMP biosynthesis" EXACT [] +synonym: "XMP formation" EXACT [] +synonym: "XMP synthesis" EXACT [] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process +is_a: GO:0097292 ! XMP metabolic process + +[Term] +id: GO:0097294 +name: 'de novo' XMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors." [GOC:yaf, MetaCyc:IMP-DEHYDROG-RXN, UniPathway:UPA00601] +synonym: "'de novo' XMP anabolism" EXACT [] +synonym: "'de novo' XMP biosynthesis" EXACT [] +synonym: "'de novo' XMP formation" EXACT [] +synonym: "'de novo' XMP synthesis" EXACT [] +is_a: GO:0097293 ! XMP biosynthetic process + +[Term] +id: GO:0097295 +name: morphine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum." [GOC:yaf, UniPathway:UPA00852] +synonym: "morphine anabolism" EXACT [] +synonym: "morphine biosynthesis" EXACT [] +synonym: "morphine formation" EXACT [] +synonym: "morphine synthesis" EXACT [] +is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process +is_a: GO:0071272 ! morphine metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:0097296 +name: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway." [GOC:mtg_apoptosis] +comment: Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. +synonym: "activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [] +synonym: "activation of initiator caspase activity" NARROW [] +is_a: GO:2001269 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway + +[Term] +id: GO:0097297 +name: activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +namespace: biological_process +def: "Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis." [GOC:mtg_apoptosis] +comment: Note that this term should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the execution phase of apoptosis (also known as an effector caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. +synonym: "activation of effector caspase activity" NARROW [] +is_a: GO:2001272 ! positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis + +[Term] +id: GO:0097298 +name: regulation of nucleus size +namespace: biological_process +def: "Any process that modulates the size of the nucleus." [GOC:al, GOC:mah, PMID:19366728] +synonym: "regulation of nuclear size" EXACT [] +synonym: "regulation of nuclear volume" EXACT [] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0097299 +name: obsolete cysteine-type endopeptidase activity involved in plant-type hypersensitive response +namespace: molecular_function +def: "OBSOLETE. Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to plant-type hypersensitive response, the rapid, localized death of plant cells in response to invasion by a pathogen." [GOC:mtg_apoptosis] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "metacaspase activity involved in plant-type hypersensitive response" NARROW [] +is_obsolete: true + +[Term] +id: GO:0097300 +name: programmed necrotic cell death +namespace: biological_process +def: "A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors." [GOC:mtg_apoptosis, PMID:21760595] +comment: This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples. +synonym: "programmed cell death by necrosis" EXACT [] +synonym: "regulated necrosis" BROAD [] +is_a: GO:0012501 ! programmed cell death +is_a: GO:0070265 ! necrotic cell death + +[Term] +id: GO:0097301 +name: regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:20412803] +synonym: "cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" EXACT [] +synonym: "potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter" BROAD [] +is_a: GO:0030007 ! cellular potassium ion homeostasis +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:0097302 +name: lipoprotein biosynthetic process via diacylglyceryl transfer +namespace: biological_process +def: "The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00664] +synonym: "lipoprotein biosynthesis (diacylglyceryl transfer)" EXACT [] +is_a: GO:0042158 ! lipoprotein biosynthetic process + +[Term] +id: GO:0097303 +name: lipoprotein biosynthetic process via N-acyl transfer +namespace: biological_process +def: "The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00666] +synonym: "lipoprotein biosynthesis (N-acyl transfer)" EXACT [] +is_a: GO:0042158 ! lipoprotein biosynthetic process + +[Term] +id: GO:0097304 +name: lipoprotein biosynthetic process via signal peptide cleavage +namespace: biological_process +def: "The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex." [GOC:pde, GOC:yaf, UniPathway:UPA00665] +synonym: "lipoprotein biosynthesis (signal peptide cleavage)" EXACT [] +is_a: GO:0042158 ! lipoprotein biosynthetic process + +[Term] +id: GO:0097305 +name: response to alcohol +namespace: biological_process +alt_id: GO:1990335 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr, PMID:24014527] +synonym: "process resulting in tolerance to alcohol" NARROW [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0097306 +name: cellular response to alcohol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [GOC:pr] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0097307 +name: response to farnesol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:pr] +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0097308 +name: cellular response to farnesol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus." [GOC:di, PMID:11425711] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:0097307 ! response to farnesol + +[Term] +id: GO:0097309 +name: cap1 mRNA methylation +namespace: biological_process +def: "Methylation of the ribose of the first nucleotide of a 5'-capped mRNA." [GOC:sp, PMID:20713356] +synonym: "cap1 mRNA capping" BROAD [] +is_a: GO:0036451 ! cap mRNA methylation + +[Term] +id: GO:0097310 +name: cap2 mRNA methylation +namespace: biological_process +def: "Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA." [GOC:sp, PMID:20713356] +synonym: "cap2 mRNA capping" BROAD [] +is_a: GO:0036451 ! cap mRNA methylation + +[Term] +id: GO:0097311 +name: bacterial biofilm matrix +namespace: cellular_component +def: "A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm] +is_a: GO:0062039 ! biofilm matrix + +[Term] +id: GO:0097312 +name: obsolete bacterial biofilm matrix component +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "biofilm matrix part" EXACT [] +is_obsolete: true +consider: GO:0097311 + +[Term] +id: GO:0097313 +name: bacterial biofilm matrix surface +namespace: cellular_component +def: "The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria." [GOC:imk, PMID:22571672, Wikipedia:Biofilm] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097311 ! bacterial biofilm matrix + +[Term] +id: GO:0097314 +name: apoptosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process." [GOC:mtg_apoptosis] +synonym: "apoptosome formation" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0097315 +name: response to N-acetyl-D-glucosamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [GOC:di, PMID:21700702] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0097316 +name: cellular response to N-acetyl-D-glucosamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus." [GOC:di, PMID:21700702] +is_a: GO:0071310 ! cellular response to organic substance +is_a: GO:0097315 ! response to N-acetyl-D-glucosamine +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0097317 +name: invasive growth in response to biotic stimulus +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus." [GOC:di, PMID:18679170] +is_a: GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus +is_a: GO:0036267 ! invasive filamentous growth + +[Term] +id: GO:0097318 +name: invasive growth in response to abiotic stimulus +namespace: biological_process +def: "The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans." [GOC:di, PMID:18679170] +is_a: GO:0009628 ! response to abiotic stimulus +is_a: GO:0036267 ! invasive filamentous growth + +[Term] +id: GO:0097320 +name: plasma membrane tubulation +namespace: biological_process +def: "A membrane tubulation process occurring in a plasma membrane." [GOC:BHF, GOC:pr, PMID:15252009, PMID:20730103] +synonym: "membrane tubulation" BROAD [] +synonym: "vesicle scission" RELATED [] +is_a: GO:0007009 ! plasma membrane organization + +[Term] +id: GO:0097321 +name: cell growth mode switching, filamentous to budding +namespace: biological_process +def: "The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans." [GOC:di, PMID:14617167] +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells + +[Term] +id: GO:0097322 +name: 7SK snRNA binding +namespace: molecular_function +def: "Binding to a 7SK small nuclear RNA (7SK snRNA)." [GOC:nhn, PMID:21853533] +synonym: "7SK small nuclear RNA binding" EXACT [] +is_a: GO:0017069 ! snRNA binding + +[Term] +id: GO:0097323 +name: B cell adhesion +namespace: biological_process +def: "The attachment of a B cell to another cell via adhesion molecules." [GOC:jc] +is_a: GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:0097324 +name: melanocyte migration +namespace: biological_process +def: "The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532] +is_a: GO:0010631 ! epithelial cell migration + +[Term] +id: GO:0097325 +name: melanocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance." [CL:0000148, GOC:uh, PMID:22637532] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:0097326 +name: melanocyte adhesion +namespace: biological_process +def: "The attachment of a melanocyte to another cell via adhesion molecules." [CL:0000148, GOC:uh, PMID:22637532] +is_a: GO:0090136 ! epithelial cell-cell adhesion + +[Term] +id: GO:0097327 +name: response to antineoplastic agent +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms." [GOC:pr] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0097328 +name: response to carboplatin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus." [GOC:pr] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0097329 +name: response to antimetabolite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization." [GOC:pr] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0097330 +name: response to 5-fluoro-2'-deoxyuridine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0097331 +name: response to cytarabine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1903416 ! response to glycoside + +[Term] +id: GO:0097332 +name: response to antipsychotic drug +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect." [GOC:pr] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0097333 +name: response to olanzapine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0097334 +name: response to perphenazine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:0097335 +name: response to quetiapine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0097336 +name: response to risperidone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:0097337 +name: response to ziprasidone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0097338 +name: response to clozapine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus." [GOC:pr] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:0097339 +name: glycolate transmembrane transport +namespace: biological_process +def: "The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid)." [GOC:am, PMID:11283302, PMID:11785976] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "glycolate membrane transport" EXACT [] +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1900866 ! glycolate transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0097340 +name: inhibition of cysteine-type endopeptidase activity +namespace: biological_process +def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase." [GOC:mtg_apoptosis, PMID:20383739] +synonym: "inhibition of caspase activity" NARROW [] +synonym: "prevention of caspase activity" NARROW [] +synonym: "prevention of cysteine-type endopeptidase activity" EXACT [] +is_a: GO:0097341 ! zymogen inhibition +is_a: GO:2000117 ! negative regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:0097341 +name: zymogen inhibition +namespace: biological_process +def: "Any process that prevents the proteolytic processing of an inactive enzyme to an active form." [GOC:mtg_apoptosis, PMID:20383739] +synonym: "prevention of zymogen activation" EXACT [] +is_a: GO:0010955 ! negative regulation of protein processing + +[Term] +id: GO:0097342 +name: ripoptosome +namespace: cellular_component +def: "A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400] +comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330). +synonym: "necrosome" RELATED [] +synonym: "TNFR1 complex II" NARROW [PMID:22089168] +synonym: "Tnfr1-CII" NARROW [PMID:22089168] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0097343 +name: ripoptosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more." [GOC:mtg_apoptosis, PMID:22274400] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0097344 +name: Rix1 complex +namespace: cellular_component +def: "A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes." [GOC:vw, PMID:14759368, PMID:15260980, PMID:21385875] +synonym: "IPI complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097345 +name: mitochondrial outer membrane permeabilization +namespace: biological_process +def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:pg, PMID:21041309] +comment: BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively). +synonym: "mitochondrial outer membrane permeabilization during apoptotic cell death" BROAD [] +synonym: "mitochondrion outer membrane permeabilization" EXACT [] +synonym: "MOMP" EXACT [] +is_a: GO:1902110 ! positive regulation of mitochondrial membrane permeability involved in apoptotic process +relationship: part_of GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:0097346 +name: INO80-type complex +namespace: cellular_component +def: "A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair." [GOC:rb, PMID:19355820] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0097347 +name: TAM protein secretion complex +namespace: cellular_component +def: "A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane." [GOC:am, PMID:22466966] +synonym: "translocation and assembly module protein complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097348 +name: host cell endocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a host cell endocytic vesicle." [GOC:ecd] +is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane + +[Term] +id: GO:0097350 +name: neutrophil clearance +namespace: biological_process +def: "The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms." [GOC:BHF, PMID:21957127] +is_a: GO:0043277 ! apoptotic cell clearance +relationship: part_of GO:0001780 ! neutrophil homeostasis + +[Term] +id: GO:0097351 +name: toxin sequestering activity +namespace: molecular_function +def: "Binding to a toxic protein, disabling its function. There may be more than one antitoxin to a toxic protein. Instances of this activity are known only in prokaryotes, where the toxic protein may be a ribonuclease, a DNA gyrase, or other." [GOC:rs, PMID:19143615, PMID:19325885, PMID:21819231, PMID:22545240, PMID:24806488, Wikipedia:Toxin-antitoxin_system#Type_II] +synonym: "toxin-antitoxin pair type I binding" NARROW [] +synonym: "toxin-antitoxin pair type II binding" NARROW [] +is_a: GO:0140313 ! molecular sequestering activity + +[Term] +id: GO:0097352 +name: autophagosome maturation +namespace: biological_process +alt_id: GO:0000046 +def: "Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling." [GOC:autophagy, GOC:lf, PMID:28077293] +synonym: "autophagic vacuole fusion" EXACT [GOC:autophagy] +synonym: "autophagic vacuole maturation" EXACT [GOC:autophagy] +synonym: "autophagosome fusion" RELATED [] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:0097353 +name: centrolateral pattern formation +namespace: biological_process +def: "The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment." [GOC:dsz] +synonym: "mediolateral pattern formation" EXACT [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:0097354 +name: prenylation +namespace: biological_process +def: "The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, PMID:18029206, PMID:21351751, PMID:22123822, PMID:22642693, PMID:22660767] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0097355 +name: protein localization to heterochromatin +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] +synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] +is_a: GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:0097356 +name: perinucleolar compartment +namespace: cellular_component +def: "The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC." [GOC:vw, PMID:21385875, Wikipedia:Perinucleolar_compartment] +synonym: "perinucleolar region" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:0097358 +name: D-leucyl-tRNA(Leu) deacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu)." [GOC:se, PMID:10918062] +is_a: GO:0051499 ! D-aminoacyl-tRNA deacylase activity + +[Term] +id: GO:0097359 +name: UDP-glucosylation +namespace: biological_process +def: "The covalent attachment of a UDP-glucose residue to a substrate molecule." [GOC:al] +is_a: GO:0006011 ! UDP-glucose metabolic process + +[Term] +id: GO:0097360 +name: chorionic trophoblast cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population." [CL:0011101, GOC:BHF, PMID:15150278] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:0097361 +name: CIA complex +namespace: cellular_component +def: "The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity." [GOC:sp, PMID:22678362] +synonym: "cytosolic iron-sulfur protein assembly complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0097362 +name: MCM8-MCM9 complex +namespace: cellular_component +def: "A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links." [GOC:sp, PMID:22771115, PMID:22771120] +is_a: GO:0042555 ! MCM complex + +[Term] +id: GO:0097363 +name: protein O-GlcNAc transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine." [GOC:jsg, GOC:sart, PMID:22158438] +synonym: "O-GlcNAc transferase" EXACT [] +synonym: "O-linked N-acetylglucosaminyltransferase" EXACT [] +synonym: "OGTase" EXACT [] +synonym: "UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase" EXACT [] +xref: EC:2.4.1.255 +xref: Reactome:R-HSA-9687828 "O-GlcNAcylation of RIPK3 (TLR4 signaling)" +is_a: GO:0016757 ! glycosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0097364 +name: stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758] +is_a: GO:0015275 ! stretch-activated, cation-selective, calcium channel activity + +[Term] +id: GO:0097365 +name: stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:21290758] +is_a: GO:0097364 ! stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential + +[Term] +id: GO:0097366 +name: response to bronchodilator +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to bronchodilator agent" EXACT [] +synonym: "response to broncholytic agent" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:0097367 +name: carbohydrate derivative binding +namespace: molecular_function +def: "Binding to a carbohydrate derivative." [GOC:pr] +subset: goslim_agr +subset: goslim_mouse +is_a: GO:0005488 ! binding + +[Term] +id: GO:0097368 +name: establishment of Sertoli cell barrier +namespace: biological_process +def: "Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions." [GOC:sl, PMID:19509333, Wikipedia:Blood-testis_barrier] +synonym: "establishment of blood-testis barrier" EXACT [] +synonym: "establishment of BTB" EXACT [] +synonym: "establishment of SCB" EXACT [] +is_a: GO:0060009 ! Sertoli cell development + +[Term] +id: GO:0097370 +name: protein O-GlcNAcylation via threonine +namespace: biological_process +def: "The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine." [GOC:pr, GOC:sart, PMID:22158438] +is_a: GO:0018243 ! protein O-linked glycosylation via threonine +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:0097371 +name: MDM2/MDM4 family protein binding +namespace: molecular_function +def: "Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53." [InterPro:IPR016495] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097372 +name: NAD-dependent histone deacetylase activity (H3-K18 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein." [GOC:sp, PMID:22722849, PMID:28450737] +is_a: GO:0017136 ! NAD-dependent histone deacetylase activity +is_a: GO:0034739 ! histone deacetylase activity (H4-K16 specific) + +[Term] +id: GO:0097373 +name: MCM core complex +namespace: cellular_component +def: "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated." [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914] +synonym: "MCM4/6/7 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097374 +name: sensory neuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses." [CL:0000101, GOC:pr] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0097375 +name: spinal sensory neuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord." [CL:0009000, GOC:pr, GOC:yaf] +is_a: GO:0097374 ! sensory neuron axon guidance + +[Term] +id: GO:0097376 +name: interneuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions." [CL:0000099, GOC:pr] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0097377 +name: spinal cord interneuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord." [CL:0005000, GOC:pr] +is_a: GO:0097376 ! interneuron axon guidance + +[Term] +id: GO:0097378 +name: dorsal spinal cord interneuron axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord." [GOC:yaf] +synonym: "dorsal interneuron axon guidance" EXACT [] +is_a: GO:0097377 ! spinal cord interneuron axon guidance + +[Term] +id: GO:0097379 +name: dorsal spinal cord interneuron posterior axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367] +synonym: "dorsal interneuron caudal axon projection" RELATED [] +is_a: GO:0033564 ! anterior/posterior axon guidance +is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance + +[Term] +id: GO:0097380 +name: dorsal spinal cord interneuron anterior axon guidance +namespace: biological_process +def: "The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:yaf, PMID:19545367] +synonym: "dorsal interneuron rostral axon projection" RELATED [] +is_a: GO:0033564 ! anterior/posterior axon guidance +is_a: GO:0097378 ! dorsal spinal cord interneuron axon guidance + +[Term] +id: GO:0097381 +name: photoreceptor disc membrane +namespace: cellular_component +def: "Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane." [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0001750 ! photoreceptor outer segment + +[Term] +id: GO:0097382 +name: deoxynucleoside-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate." [GOC:pde] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0097383 +name: dIDP diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: dIDP + H2O = dIMP + phosphate." [GOC:pde, PMID:20385596] +synonym: "deoxyinosine-diphosphatase activity" EXACT [] +xref: Reactome:R-HSA-2509793 "NUDT16 hydrolyses dIDP to dIMP" +xref: RHEA:35211 +is_a: GO:0097382 ! deoxynucleoside-diphosphatase activity + +[Term] +id: GO:0097384 +name: cellular lipid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells." [GOC:pr] +synonym: "cellular lipid anabolism" EXACT [] +synonym: "cellular lipid biosynthesis" EXACT [] +synonym: "cellular lipid formation" EXACT [] +synonym: "cellular lipid synthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044255 ! cellular lipid metabolic process + +[Term] +id: GO:0097385 +name: programmed necrotic cell death in response to starvation +namespace: biological_process +def: "A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment)." [GOC:mtg_apoptosis, GOC:pg, PMID:13679856] +synonym: "necrotic cell death in response to starvation" BROAD [] +is_a: GO:0042594 ! response to starvation +is_a: GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:0097386 +name: glial cell projection +namespace: cellular_component +def: "A prolongation or process extending from a glial cell." [GOC:mc] +synonym: "glial process" RELATED [] +synonym: "glial projection" RELATED [] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0097387 +name: capitate projection +namespace: cellular_component +def: "Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies)." [GOC:mc, PMID:3098431] +is_a: GO:0097386 ! glial cell projection + +[Term] +id: GO:0097388 +name: chemokine (C-C motif) ligand 19 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL19 production" EXACT [] +synonym: "EBI1 ligand chemokine production" EXACT [] +synonym: "ELC production" EXACT [] +synonym: "macrophage inflammatory protein-3-beta production" EXACT [] +synonym: "MIP-3-beta production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0097389 +name: chemokine (C-C motif) ligand 21 production +namespace: biological_process +def: "The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CCL21 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0097390 +name: chemokine (C-X-C motif) ligand 12 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CXCL12 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0097391 +name: chemokine (C-X-C motif) ligand 13 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CXCL13 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0097392 +name: chemokine (C-X-C motif) ligand 16 production +namespace: biological_process +def: "The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv] +subset: gocheck_do_not_annotate +synonym: "CXCL16 production" EXACT [] +is_a: GO:0032602 ! chemokine production + +[Term] +id: GO:0097393 +name: telomeric repeat-containing RNA transcription +namespace: biological_process +def: "The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome." [GOC:al, PMID:22139915] +synonym: "TERRA transcription" EXACT [PMID:22139915] +is_a: GO:0034660 ! ncRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0097394 +name: telomeric repeat-containing RNA transcription by RNA polymerase II +namespace: biological_process +def: "The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter." [GOC:al, PMID:22139915] +synonym: "telomeric repeat-containing RNA transcription from RNA pol II promoter" EXACT [] +synonym: "telomeric RNA transcription from Pol II promoter" RELATED [] +synonym: "TERRA RNA transcription from RNA pol II promoter" RELATED [GOC:22139915] +is_a: GO:0006366 ! transcription by RNA polymerase II +is_a: GO:0097393 ! telomeric repeat-containing RNA transcription + +[Term] +id: GO:0097395 +name: response to interleukin-32 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr] +synonym: "response to IL-32" EXACT [] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0097396 +name: response to interleukin-17 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] +synonym: "response to IL-17" EXACT [] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0097397 +name: cellular response to interleukin-32 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus." [GOC:pr] +synonym: "cellular response to IL-32" EXACT [] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:0097395 ! response to interleukin-32 + +[Term] +id: GO:0097398 +name: cellular response to interleukin-17 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus." [GOC:pr] +synonym: "cellular response to IL-17" EXACT [] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:0097396 ! response to interleukin-17 + +[Term] +id: GO:0097399 +name: interleukin-32-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-32 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] +synonym: "IL-32-mediated signaling pathway" EXACT [] +synonym: "IL-32-mediated signalling pathway" EXACT [] +synonym: "interleukin-32-mediated signalling pathway" EXACT [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0097397 ! cellular response to interleukin-32 + +[Term] +id: GO:0097400 +name: interleukin-17-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-17 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ic, PMID:21602493] +synonym: "IL-17-mediated signaling pathway" EXACT [] +synonym: "IL-17-mediated signalling pathway" EXACT [] +synonym: "interleukin-17-mediated signalling pathway" EXACT [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway +relationship: part_of GO:0097398 ! cellular response to interleukin-17 + +[Term] +id: GO:0097401 +name: synaptic vesicle lumen acidification +namespace: biological_process +def: "The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading." [GOC:dsf, PMID:21172605, PMID:22875945] +subset: goslim_synapse +synonym: "synaptic vesicle lumen pH reduction" EXACT [] +synonym: "synaptic vesicle proton loading" EXACT syngo_official_label [] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0070050 ! neuron cellular homeostasis +is_a: GO:1902600 ! proton transmembrane transport +relationship: part_of GO:0016188 ! synaptic vesicle maturation +relationship: part_of GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0097402 +name: neuroblast migration +namespace: biological_process +def: "The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron." [CL:0000031, GOC:jc, PMID:15543145] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0097403 +name: cellular response to raffinose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:al] +is_a: GO:0071322 ! cellular response to carbohydrate stimulus +is_a: GO:1901545 ! response to raffinose + +[Term] +id: GO:0097407 +name: Bunina body +namespace: cellular_component +def: "Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles." [NIF_Subcellular:nlx_subcell_20090101, PMID:18026741] +xref: NIF_Subcellular:nlx_subcell_20090101 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097408 +name: fibrillary inclusion +namespace: cellular_component +def: "Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra." [NIF_Subcellular:sao967812059] +xref: NIF_Subcellular:sao967812059 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097409 +name: glial cytoplasmic inclusion +namespace: cellular_component +def: "Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy." [NIF_Subcellular:nlx_subcell_20090703, PMID:21562886, PMID:2559165] +synonym: "GCI" EXACT [] +synonym: "Papp-Lantos body" RELATED [] +xref: NIF_Subcellular:nlx_subcell_20090703 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097410 +name: hippocampal interneuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron." [CL:1001569, GOC:jc, PMID:19655320] +is_a: GO:0030182 ! neuron differentiation +relationship: part_of GO:0021766 ! hippocampus development + +[Term] +id: GO:0097411 +name: hypoxia-inducible factor-1alpha signaling pathway +namespace: biological_process +def: "A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia." [GOC:bf, GOC:jc, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway] +synonym: "HIF1alpha pathway" EXACT [] +synonym: "hypoxia-inducible factor signaling" EXACT [GOC:bf] +synonym: "hypoxia-inducible factor-1alpha signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:0097412 +name: hyaline inclusion +namespace: cellular_component +def: "A glass-like, pale intracellular inclusion." [NIF_Subcellular:nlx_subcell_20090104] +synonym: "pale body" RELATED [] +xref: NIF_Subcellular:nlx_subcell_20090104 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097413 +name: Lewy body +namespace: cellular_component +def: "Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein." [NIF_Subcellular:sao4933778419] +synonym: "cytoplasmic inclusion" RELATED [] +xref: NIF_Subcellular:sao4933778419 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097414 +name: classical Lewy body +namespace: cellular_component +def: "Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils." [NIF_Subcellular:sao4749542545] +synonym: "brainstem Lewy body" RELATED [] +xref: NIF_Subcellular:sao4749542545 +is_a: GO:0097413 ! Lewy body + +[Term] +id: GO:0097415 +name: cortical Lewy body +namespace: cellular_component +def: "Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils." [NIF_Subcellular:sao4040591221] +xref: NIF_Subcellular:sao4040591221 +is_a: GO:0097413 ! Lewy body + +[Term] +id: GO:0097416 +name: Lewy body-like hyaline inclusion +namespace: cellular_component +def: "Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments." [NIF_Subcellular:nlx_subcell_20090105, PMID:18026741] +synonym: "LBHI" EXACT [] +xref: NIF_Subcellular:nlx_subcell_20090105 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097417 +name: nematosome +namespace: cellular_component +def: "Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles." [NIF_Subcellular:sao138430598, PMID:5458990] +xref: NIF_Subcellular:sao138430598 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097418 +name: neurofibrillary tangle +namespace: cellular_component +def: "Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star." [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926] +comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). +synonym: "flame-shaped neurofibrillary tangle" NARROW [] +synonym: "star-shaped neurofibrillary tangle" NARROW [] +xref: NIF_Subcellular:nlx_subcell_20090201 +xref: NIF_Subcellular:nlx_subcell_20090202 +xref: NIF_Subcellular:sao2409833926 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097419 +name: Pick body +namespace: cellular_component +def: "Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E." [NIF_Subcellular:nlx_subcell_20090102] +xref: NIF_Subcellular:nlx_subcell_20090102 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097420 +name: skein-like inclusion +namespace: cellular_component +def: "Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin." [NIF_Subcellular:nlx_subcell_20090103, PMID:18026741] +xref: NIF_Subcellular:nlx_subcell_20090103 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:0097421 +name: liver regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed liver." [GOC:gap, PMID:19447520] +is_a: GO:0001889 ! liver development +is_a: GO:0031100 ! animal organ regeneration + +[Term] +id: GO:0097422 +name: tubular endosome +namespace: cellular_component +def: "A network of fine tubules in the vicinity of the Golgi complex and around the centriole." [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161] +synonym: "coated tip" RELATED [] +xref: NIF_Subcellular:sao1570660411 +xref: NIF_Subcellular:sao694815499 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005768 ! endosome + +[Term] +id: GO:0097423 +name: mitochondrion-associated adherens complex +namespace: cellular_component +def: "An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans." [NIF_Subcellular:sao1933817066, PMID:20089910] +synonym: "MAC" RELATED [] +synonym: "mitochondrial adhaerens complex" EXACT [] +xref: NIF_Subcellular:sao1933817066 +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097424 +name: nucleolus-associated heterochromatin +namespace: cellular_component +def: "Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus." [NIF_Subcellular:sao1210952635] +xref: NIF_Subcellular:sao1210952635 +is_a: GO:0030874 ! nucleolar chromatin + +[Term] +id: GO:0097425 +name: obsolete smooth endoplasmic reticulum part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of the smooth endoplasmic reticulum (also called smooth ER, or SER)." [NIF_Subcellular:sao184202831] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_annotate +synonym: "SER subcomponent" RELATED [NIF_Subcellular:sao1842028314] +xref: NIF_Subcellular:sao184202831 +is_obsolete: true +consider: GO:0005790 + +[Term] +id: GO:0097426 +name: glial filament +namespace: cellular_component +def: "An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes." [NIF_Subcellular:sao1863852493] +xref: NIF_Subcellular:sao1863852493 +is_a: GO:0005882 ! intermediate filament + +[Term] +id: GO:0097427 +name: microtubule bundle +namespace: cellular_component +def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] +synonym: "microtubule fascicle" EXACT [] +xref: NIF_Subcellular:sao1872343973 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0097428 +name: protein maturation by iron-sulfur cluster transfer +namespace: biological_process +def: "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977] +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0097429 +name: amino acid ligation activity by nonribosomal peptide synthase +namespace: molecular_function +def: "Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase." [GOC:vw] +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0097430 +name: copper ion import across prospore membrane +namespace: biological_process +def: "The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol." [GOC:al, GOC:vw, PMID:21828039] +synonym: "copper ion import into ascospore-type prospore" RELATED [] +synonym: "copper ion transport into forespores" RELATED [] +is_a: GO:0015677 ! copper ion import +is_a: GO:0035434 ! copper ion transmembrane transport + +[Term] +id: GO:0097431 +name: mitotic spindle pole +namespace: cellular_component +def: "Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:vw] +is_a: GO:0000922 ! spindle pole +relationship: part_of GO:0072686 ! mitotic spindle + +[Term] +id: GO:0097432 +name: hippocampal pyramidal neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus." [CL:1001571, GOC:jc, PMID:19342486] +is_a: GO:0021859 ! pyramidal neuron differentiation + +[Term] +id: GO:0097433 +name: dense body +namespace: cellular_component +def: "An electron dense body which may contain granules." [ISBN:0195065719, NIF_Subcellular:sao730872736] +xref: NIF_Subcellular:sao730872736 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0097434 +name: succinate:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in)." [GOC:al, PMID:1293882] +synonym: "succinate:hydrogen symporter activity" EXACT [] +is_a: GO:0015141 ! succinate transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0097435 +name: supramolecular fiber organization +namespace: biological_process +alt_id: GO:0043206 +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:pr] +synonym: "extracellular fibril organisation" NARROW [] +synonym: "extracellular fibril organization" NARROW [] +synonym: "extracellular fibril organization and biogenesis" NARROW [GOC:mah] +synonym: "fibril organisation" RELATED [] +synonym: "fibril organization" RELATED [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:0097436 +name: entry into dormancy +namespace: biological_process +def: "The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] +synonym: "induction of dormancy" EXACT [] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0097437 +name: maintenance of dormancy +namespace: biological_process +def: "The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0097438 +name: exit from dormancy +namespace: biological_process +def: "The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated." [GOC:PO_curators, PO_REF:00009] +synonym: "release from dormancy" EXACT [] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0097439 +name: acquisition of desiccation tolerance +namespace: biological_process +def: "The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state." [GOC:PO_curators] +is_a: GO:0022611 ! dormancy process + +[Term] +id: GO:0097440 +name: apical dendrite +namespace: cellular_component +def: "A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon." [NIF_Subcellular:sao273773228] +xref: NIF_Subcellular:sao273773228 +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0097441 +name: basal dendrite +namespace: cellular_component +def: "A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681] +synonym: "basilar dendrite" EXACT [NIF_Subcellular:sao1079900774] +xref: NIF_Subcellular:sao1079900774 +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0097442 +name: CA3 pyramidal cell dendrite +namespace: cellular_component +def: "A dendrite of a hippocampal CA3 pyramidal cell." [NIF_Subcellular:nlx_subcell_1005001] +xref: NIF_Subcellular:nlx_subcell_1005001 +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0097443 +name: sorting endosome +namespace: cellular_component +def: "A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles." [NIF_Subcellular:sao1028571114] +synonym: "MVB-tubule complex" RELATED [] +xref: NIF_Subcellular:sao1028571114 +is_a: GO:0005768 ! endosome + +[Term] +id: GO:0097444 +name: spine apparatus +namespace: cellular_component +def: "A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum." [NIF_Subcellular:sao725931194, PMID:20400711, PMID:8987748] +subset: goslim_synapse +synonym: "dense material" NARROW [NIF_Subcellular:sao1004601938] +xref: NIF_Subcellular:sao725931194 +is_a: GO:0043227 ! membrane-bounded organelle +relationship: part_of GO:0012505 ! endomembrane system +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0097445 +name: presynaptic active zone dense projection +namespace: cellular_component +def: "Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered." [NIF_Subcellular:sao494258938, PMID:15381754] +synonym: "active zone dense projection" EXACT [] +synonym: "pre-synaptic active zone dense projection" EXACT [] +xref: NIF_Subcellular:sao494258938 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:0097446 +name: protein localization to eisosome filament +namespace: biological_process +def: "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945] +synonym: "protein localization to linear eisosome" EXACT [] +is_a: GO:0044380 ! protein localization to cytoskeleton +is_a: GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:0097447 +name: dendritic tree +namespace: cellular_component +def: "The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches." [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168] +xref: NIF_Subcellular:sao172297168 +is_a: GO:0043005 ! neuron projection +relationship: part_of GO:0036477 ! somatodendritic compartment + +[Term] +id: GO:0097448 +name: spine mat +namespace: cellular_component +def: "A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma." [NIF_Subcellular:sao2128156969, PMID:10818137] +xref: NIF_Subcellular:sao2128156969 +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097449 +name: astrocyte projection +namespace: cellular_component +def: "A prolongation or process extending from the soma of an astrocyte and wrapping around neurons." [NIF_Subcellular:sao1630537580] +synonym: "astrocyte process" EXACT [] +synonym: "peripheral astrocyte process" RELATED [NIF_Subcellular:sao1573004591, PMID:12445894] +synonym: "vellous process" RELATED [NIF_Subcellular:sao1189060993] +xref: NIF_Subcellular:sao1630537580 +is_a: GO:0097386 ! glial cell projection + +[Term] +id: GO:0097450 +name: astrocyte end-foot +namespace: cellular_component +def: "Terminal process of astrocyte abutting non-neuronal surfaces in the brain." [NIF_Subcellular:sao388182739] +synonym: "astrocyte endfoot" EXACT [] +xref: NIF_Subcellular:sao388182739 +is_a: GO:0097449 ! astrocyte projection + +[Term] +id: GO:0097451 +name: glial limiting end-foot +namespace: cellular_component +def: "Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans." [NIF_Subcellular:sao181458425] +synonym: "glial limiting endfoot" EXACT [] +xref: NIF_Subcellular:sao181458425 +is_a: GO:0097450 ! astrocyte end-foot + +[Term] +id: GO:0097452 +name: GAIT complex +namespace: cellular_component +def: "A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP." [GOC:br, PMID:15479637, PMID:23071094] +synonym: "gamma interferon-activated inhibitor of translation complex" EXACT [] +synonym: "IFN-gamma-activated inhibitor of translation complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0097453 +name: mesaxon +namespace: cellular_component +def: "Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide." [ISBN:0195065719, NIF_Subcellular:sao2127666702] +synonym: "mesaxon of Schwann cell" NARROW [] +xref: NIF_Subcellular:sao2127666702 +is_a: GO:1990015 ! ensheathing process + +[Term] +id: GO:0097454 +name: Schwann cell microvillus +namespace: cellular_component +def: "Small finger-like extension of a Schwann cell that contacts the nodal membrane." [NIF_Subcellular:sao1890444066, PMID:15988042] +xref: NIF_Subcellular:sao1890444066 +is_a: GO:0005902 ! microvillus +is_a: GO:0097386 ! glial cell projection + +[Term] +id: GO:0097455 +name: spiny bracelet of Nageotte +namespace: cellular_component +def: "Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin." [NIF_Subcellular:sao937871668, PMID:15988042] +xref: NIF_Subcellular:sao937871668 +is_a: GO:0097386 ! glial cell projection + +[Term] +id: GO:0097456 +name: terminal loop +namespace: cellular_component +def: "Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath." [NIF_Subcellular:sao924713546] +synonym: "terminal loop of Schwann cell" EXACT [] +xref: NIF_Subcellular:sao924713546 +is_a: GO:0097386 ! glial cell projection + +[Term] +id: GO:0097457 +name: hippocampal mossy fiber +namespace: cellular_component +def: "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709] +xref: NIF_Subcellular:nlx_subcell_100312 +is_a: GO:0044302 ! dentate gyrus mossy fiber + +[Term] +id: GO:0097458 +name: obsolete neuron part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system." [GOC:pr, Wikipedia:Neuron] +subset: gocheck_do_not_annotate +subset: goslim_flybase_ribbon +is_obsolete: true +consider: CL:0000540 + +[Term] +id: GO:0097462 +name: Lewy neurite +namespace: cellular_component +def: "Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease." [NIF_Subcellular:sao601362597] +xref: NIF_Subcellular:sao601362597 +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0097463 +name: gemmule +namespace: cellular_component +def: "Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex." [NIF_Subcellular:nlx_subcell_1005003] +xref: NIF_Subcellular:nlx_subcell_1005003 +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0097464 +name: thorny excrescence +namespace: cellular_component +def: "Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads." [NIF_Subcellular:nlx_467, PMID:730852] +xref: NIF_Subcellular:nlx_467 +is_a: GO:0043197 ! dendritic spine + +[Term] +id: GO:0097465 +name: somatic spine +namespace: cellular_component +def: "Spine emanating from the cell soma of a neuron." [NIF_Subcellular:sao2048514053] +xref: NIF_Subcellular:sao2048514053 +is_a: GO:0044309 ! neuron spine + +[Term] +id: GO:0097466 +name: ubiquitin-dependent glycoprotein ERAD pathway +namespace: biological_process +def: "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177] +synonym: "ER-associated glycoprotein degradation" EXACT [GOC:bf] +synonym: "glycoprotein ERAD" EXACT [GOC:bf] +synonym: "gpERAD" EXACT [PMID:25092655] +synonym: "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [] +is_a: GO:0006516 ! glycoprotein catabolic process +is_a: GO:0030433 ! ubiquitin-dependent ERAD pathway +is_a: GO:1904587 ! response to glycoprotein + +[Term] +id: GO:0097467 +name: type III terminal bouton +namespace: cellular_component +def: "Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones." [GOC:mc, PMID:10218156] +synonym: "type III terminal button" EXACT [] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:0097468 +name: programmed cell death in response to reactive oxygen species +namespace: biological_process +def: "Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mtg_apoptosis] +synonym: "PCD in response to oxidative stress" BROAD [] +synonym: "PCD in response to reactive oxygen species" EXACT [] +synonym: "programmed cell death in response to oxidative stress" BROAD [] +synonym: "reactive oxygen species-mediated PCD" EXACT [] +synonym: "reactive oxygen species-mediated programmed cell death" EXACT [] +is_a: GO:0012501 ! programmed cell death +is_a: GO:0036473 ! cell death in response to oxidative stress +relationship: part_of GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:0097469 +name: obsolete cyclin-dependent protein tyrosine kinase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. This reaction requires the binding of a regulatory cyclin subunit." [GOC:al, GOC:vw, PMID:1372994] +comment: This term was made obsolete because it was added in error; the specific activity it refers to has never been observed. +synonym: "cyclin-dependent protein tyrosine kinase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:0097470 +name: ribbon synapse +namespace: cellular_component +def: "Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm." [NIF_Subcellular:sao1884931180, PMID:15626493] +synonym: "synapsis fasciolaris" EXACT [Wikipedia:Ribbon_synapse&oldid=757407851] +xref: NIF_Subcellular:sao1884931180 +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0097471 +name: mossy fiber rosette +namespace: cellular_component +def: "A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes." [NIF_Subcellular:nlx_subcell_091021, Wikipedia:Mossy_fiber_(cerebellum)] +subset: goslim_synapse +synonym: "cerebellar mossy fiber to granule cell synapse" EXACT syngo_official_label [] +xref: NIF_Subcellular:nlx_subcell_091021 +is_a: GO:0032279 ! asymmetric synapse + +[Term] +id: GO:0097472 +name: cyclin-dependent protein kinase activity +namespace: molecular_function +def: "Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:pr] +comment: This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0097473 +name: retinal rod cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000604, GOC:jc, PMID:17202487] +synonym: "rod photoreceptor apoptotic process" EXACT [] +is_a: GO:0051402 ! neuron apoptotic process +is_a: GO:1990009 ! retinal cell apoptotic process + +[Term] +id: GO:0097474 +name: retinal cone cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina." [CL:0000573, GOC:jc] +synonym: "cone photoreceptor apoptotic process" EXACT [] +is_a: GO:0051402 ! neuron apoptotic process +is_a: GO:1990009 ! retinal cell apoptotic process + +[Term] +id: GO:0097475 +name: motor neuron migration +namespace: biological_process +def: "The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement." [CL:0000100, GOC:yaf, PMID:20711475] +is_a: GO:0001764 ! neuron migration + +[Term] +id: GO:0097476 +name: spinal cord motor neuron migration +namespace: biological_process +def: "The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [CL:0011001, GOC:yaf, PMID:20711475] +is_a: GO:0097475 ! motor neuron migration + +[Term] +id: GO:0097477 +name: lateral motor column neuron migration +namespace: biological_process +def: "The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." [CL:0011002, GOC:yaf, PMID:20711475] +is_a: GO:0097476 ! spinal cord motor neuron migration + +[Term] +id: GO:0097478 +name: leaflet of membrane bilayer +namespace: cellular_component +def: "Any of the two layers of lipid molecules that constitute a membrane." [GOC:cjm] +synonym: "membrane leaflet" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0097479 +name: synaptic vesicle localization +namespace: biological_process +def: "Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location." [GOC:pr] +synonym: "establishment and maintenance of synaptic vesicle localization" EXACT [] +synonym: "establishment and maintenance of synaptic vesicle position" EXACT [] +synonym: "synaptic vesicle localisation" EXACT [] +is_a: GO:0051648 ! vesicle localization + +[Term] +id: GO:0097480 +name: establishment of synaptic vesicle localization +namespace: biological_process +def: "The directed movement of a synaptic vesicle or vesicles to a specific location." [GOC:pr] +synonym: "establishment of synaptic vesicle localisation" EXACT [] +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0097479 ! synaptic vesicle localization + +[Term] +id: GO:0097482 +name: muscle cell postsynaptic specialization +namespace: cellular_component +def: "A postsynaptic specialization that is part of a neuromuscular junction." [GOC:pr] +synonym: "muscle cell postsynaptic density" EXACT [] +synonym: "muscle fiber postsynaptic density" EXACT [] +is_a: GO:0099572 ! postsynaptic specialization +relationship: part_of GO:0098975 ! postsynapse of neuromuscular junction + +[Term] +id: GO:0097484 +name: dendrite extension +namespace: biological_process +def: "Long distance growth of a single dendrite involved in cellular development." [GOC:BHF, GOC:rl] +is_a: GO:1990138 ! neuron projection extension + +[Term] +id: GO:0097485 +name: neuron projection guidance +namespace: biological_process +def: "The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] +synonym: "neurite guidance" NARROW [] +synonym: "neuron process guidance" EXACT [] +synonym: "neuron protrusion guidance" EXACT [] +synonym: "neuronal cell projection guidance" EXACT [] +is_a: GO:0006928 ! movement of cell or subcellular component +relationship: part_of GO:0006935 ! chemotaxis +relationship: part_of GO:0048812 ! neuron projection morphogenesis + +[Term] +id: GO:0097486 +name: multivesicular body lumen +namespace: cellular_component +def: "The volume enclosed by the outermost membrane of a multivesicular body." [GOC:pde, PMID:21183070] +is_a: GO:0031906 ! late endosome lumen +relationship: part_of GO:0005771 ! multivesicular body + +[Term] +id: GO:0097487 +name: multivesicular body, internal vesicle +namespace: cellular_component +def: "A membrane-bounded vesicle wholly contained within a multivesicular body." [GOC:pde, PMID:21183070] +is_a: GO:0031410 ! cytoplasmic vesicle +relationship: part_of GO:0005771 ! multivesicular body + +[Term] +id: GO:0097488 +name: multivesicular body, internal vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a multivesicular body internal vesicle." [GOC:pde, PMID:21183070] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0097487 ! multivesicular body, internal vesicle + +[Term] +id: GO:0097489 +name: multivesicular body, internal vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of the multivesicular body internal vesicle." [GOC:pde, PMID:21183070] +is_a: GO:0031983 ! vesicle lumen +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0097487 ! multivesicular body, internal vesicle + +[Term] +id: GO:0097490 +name: sympathetic neuron projection extension +namespace: biological_process +def: "Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009] +synonym: "sympathetic neurite extension" NARROW [] +synonym: "sympathetic neuron process extension" EXACT [] +synonym: "sympathetic neuron protrusion extension" EXACT [] +synonym: "sympathetic neuronal cell projection extension" EXACT [] +is_a: GO:1990138 ! neuron projection extension + +[Term] +id: GO:0097491 +name: sympathetic neuron projection guidance +namespace: biological_process +def: "The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] +synonym: "sympathetic neurite guidance" NARROW [] +synonym: "sympathetic neuron process guidance" EXACT [] +synonym: "sympathetic neuron protrusion guidance" EXACT [] +synonym: "sympathetic neuronal cell projection guidance" EXACT [] +is_a: GO:0097485 ! neuron projection guidance + +[Term] +id: GO:0097492 +name: sympathetic neuron axon guidance +namespace: biological_process +def: "The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [GOC:BHF, GOC:rl, PMID:22790009] +synonym: "sympathetic neuron axon chemotaxis" RELATED [] +synonym: "sympathetic neuron axon growth cone guidance" NARROW [] +synonym: "sympathetic neuron axon pathfinding" EXACT [] +is_a: GO:0007411 ! axon guidance + +[Term] +id: GO:0097493 +name: structural molecule activity conferring elasticity +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling." [GOC:BHF, GOC:rl, PMID:23283722] +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0097494 +name: regulation of vesicle size +namespace: biological_process +def: "Any process that modulates the size of a vesicle." [GOC:pm, PMID:20007772] +is_a: GO:0032535 ! regulation of cellular component size + +[Term] +id: GO:0097495 +name: H-NS-Hha complex +namespace: cellular_component +def: "A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:21600204] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0097496 +name: blood vessel lumen ensheathment +namespace: biological_process +def: "A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel." [GOC:dgh, PMID:23698350] +is_a: GO:0072554 ! blood vessel lumenization + +[Term] +id: GO:0097497 +name: blood vessel endothelial cell delamination +namespace: biological_process +def: "The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet." [GOC:dgh, PMID:23698350] +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0097498 +name: endothelial tube lumen extension +namespace: biological_process +def: "Any endothelial tube morphogenesis process by which the tube is increased in length." [GOC:dgh, PMID:23698350] +is_a: GO:0061154 ! endothelial tube morphogenesis + +[Term] +id: GO:0097499 +name: protein localization to non-motile cilium +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241] +synonym: "protein localization to nonmotile primary cilium" RELATED [] +is_a: GO:0061512 ! protein localization to cilium + +[Term] +id: GO:0097500 +name: receptor localization to non-motile cilium +namespace: biological_process +def: "A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium." [GOC:cilia, GOC:kmv, PMID:23128241] +synonym: "receptor localization to nonmotile primary cilium" RELATED [] +is_a: GO:0097499 ! protein localization to non-motile cilium +is_a: GO:1903441 ! protein localization to ciliary membrane + +[Term] +id: GO:0097501 +name: stress response to metal ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus." [GOC:kmv] +synonym: "response to excess metal ion" RELATED [] +synonym: "response to metal ion stress" EXACT [] +synonym: "response to metal ion toxicity" RELATED [] +synonym: "response to metal toxicity" RELATED [] +is_a: GO:0006950 ! response to stress +is_a: GO:0010038 ! response to metal ion + +[Term] +id: GO:0097502 +name: mannosylation +namespace: biological_process +def: "The covalent attachment of a mannose residue to a substrate molecule." [GOC:cjm] +is_a: GO:0070085 ! glycosylation + +[Term] +id: GO:0097503 +name: sialylation +namespace: biological_process +def: "The covalent attachment of sialic acid to a substrate molecule." [GOC:cjm] +is_a: GO:0043412 ! macromolecule modification + +[Term] +id: GO:0097504 +name: Gemini of coiled bodies +namespace: cellular_component +def: "Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA)." [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems] +synonym: "Gems" EXACT [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:0097505 +name: Rad6-Rad18 complex +namespace: cellular_component +def: "A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity." [GOC:jd, PMID:9287349] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:0097506 +name: deaminated base DNA N-glycosylase activity +namespace: molecular_function +def: "DNA N-glycosylase activity acting on deaminated bases." [GOC:al, PMID:18789404] +synonym: "deaminated base DNA glycosylase activity" EXACT [] +synonym: "DNA glycosylase activity acting on deaminated bases" EXACT [] +is_a: GO:0019104 ! DNA N-glycosylase activity + +[Term] +id: GO:0097507 +name: hypoxanthine DNA N-glycosylase activity +namespace: molecular_function +def: "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)." [GOC:al, PMID:18789404] +synonym: "hypoxanthine-DNA glycosylase activity" RELATED [] +is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity + +[Term] +id: GO:0097508 +name: xanthine DNA N-glycosylase activity +namespace: molecular_function +def: "DNA N-glycosylase activity acting on deaminated guanine (xanthine)." [GOC:al, PMID:18789404] +synonym: "xanthine-DNA glycosylase activity" RELATED [] +is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity + +[Term] +id: GO:0097509 +name: oxanine DNA N-glycosylase activity +namespace: molecular_function +def: "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination." [GOC:al, PMID:18789404] +synonym: "oxanine-DNA glycosylase activity" RELATED [] +is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity + +[Term] +id: GO:0097510 +name: base-excision repair, AP site formation via deaminated base removal +namespace: biological_process +def: "A base-excision repair, AP site formation process occurring via excision of a deaminated base." [GOC:al, PMID:18789404] +is_a: GO:0006285 ! base-excision repair, AP site formation + +[Term] +id: GO:0097511 +name: dendritic cell dendrite +namespace: cellular_component +def: "A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells." [CL:0000451, GOC:BHF, GOC:cjm, PMID:12200351] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0097512 +name: cardiac myofibril +namespace: cellular_component +def: "A cardiac myofibril is a myofibril specific to cardiac muscle cells." [GOC:cjm, GOC:devbiol] +is_a: GO:0030016 ! myofibril + +[Term] +id: GO:0097513 +name: myosin II filament +namespace: cellular_component +def: "A bipolar filament composed of myosin II molecules." [GOC:cjm, GOC:mah] +is_a: GO:0032982 ! myosin filament + +[Term] +id: GO:0097514 +name: sexual spore wall +namespace: cellular_component +def: "A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis." [GOC:cjm, GOC:mah] +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0097515 +name: asexual spore wall +namespace: cellular_component +def: "A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species." [GOC:cjm, GOC:mah] +is_a: GO:0031160 ! spore wall + +[Term] +id: GO:0097516 +name: microvillar actin bundle +namespace: cellular_component +def: "A parallel bundle of actin filaments at the core of a microvillus." [GOC:cjm, GOC:mah] +is_a: GO:0098859 ! actin filament bundle of actin-based cell projection +relationship: part_of GO:0005902 ! microvillus + +[Term] +id: GO:0097517 +name: contractile actin filament bundle +namespace: cellular_component +def: "An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:cjm, GOC:mah, ISBN:0815316194] +is_a: GO:0032432 ! actin filament bundle + +[Term] +id: GO:0097518 +name: parallel actin filament bundle +namespace: cellular_component +def: "An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:cjm, GOC:mah, ISBN:0815316194] +is_a: GO:0032432 ! actin filament bundle + +[Term] +id: GO:0097519 +name: DNA recombinase complex +namespace: cellular_component +def: "A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA." [GOC:cjm, PMID:10357855] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0097520 +name: nucleotide-excision repair, preincision complex +namespace: cellular_component +def: "A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage." [GOC:cjm, GOC:elh, PMID:10197977] +synonym: "UvrA(2)-UvrB(2) complex" NARROW [PMID:12145219] +synonym: "UvrA(2)B(2) complex" NARROW [GOC:bhm, PMID:12145219] +synonym: "UvrB dimer" NARROW [GOC:bhm, PMID:12145219] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0097522 +name: protein-DNA ISRE complex +namespace: cellular_component +def: "A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA." [GOC:amm, GOC:cjm, PMID:11747630] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0097523 +name: transcription ternary complex +namespace: cellular_component +def: "A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript." [GOC:cjm, GOC:txnOH] +synonym: "transcription protein-DNA-RNA complex" EXACT [] +is_a: GO:0001114 ! protein-DNA-RNA complex + +[Term] +id: GO:0097524 +name: sperm plasma membrane +namespace: cellular_component +def: "A plasma membrane that is part of a sperm cell." [GOC:cjm] +is_a: GO:0005886 ! plasma membrane + +[Term] +id: GO:0097525 +name: spliceosomal snRNP complex +namespace: cellular_component +def: "A small ribonucleoprotein complex involved in formation of the spliceosome." [GOC:krc, GOC:pr, ISBN:0879695897] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex + +[Term] +id: GO:0097526 +name: spliceosomal tri-snRNP complex +namespace: cellular_component +def: "A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP." [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384] +is_a: GO:0097525 ! spliceosomal snRNP complex + +[Term] +id: GO:0097527 +name: necroptotic signaling pathway +namespace: biological_process +def: "A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered." [GOC:mtg_apoptosis, PMID:20823910] +comment: Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality. +synonym: "necroptosis signaling" RELATED [] +synonym: "necroptosis signaling pathway" EXACT [] +synonym: "necroptotic signal transduction" EXACT [GOC:signaling] +synonym: "necroptotic signalling pathway" RELATED [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0070266 ! necroptotic process + +[Term] +id: GO:0097528 +name: execution phase of necroptosis +namespace: biological_process +def: "A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died." [GOC:mtg_apoptosis, PMID:20823910] +synonym: "execution phase of necroptotic process" EXACT [] +synonym: "necroptosis" BROAD [] +synonym: "necroptotic execution phase" EXACT [] +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0070266 ! necroptotic process + +[Term] +id: GO:0097529 +name: myeloid leukocyte migration +namespace: biological_process +def: "The movement of a myeloid leukocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:22342843, PMID:24157461] +is_a: GO:0050900 ! leukocyte migration + +[Term] +id: GO:0097530 +name: granulocyte migration +namespace: biological_process +def: "The movement of a granulocyte within or between different tissues and organs of the body." [GOC:cvs, PMID:24163421, PMID:24193336] +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:0097531 +name: mast cell migration +namespace: biological_process +def: "The movement of a mast cell within or between different tissues and organs of the body." [GOC:cvs, PMID:24152847] +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:0097532 +name: stress response to acid chemical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid] +synonym: "response to acid stress" BROAD [] +synonym: "stress response to acid" BROAD [] +is_a: GO:0001101 ! response to acid chemical +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:0097533 +name: cellular stress response to acid chemical +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:aa, GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049, PMID:19170886, Wikipedia:Acid] +synonym: "cellular response to acid stress" BROAD [] +synonym: "cellular stress response to acid" BROAD [] +is_a: GO:0097532 ! stress response to acid chemical +relationship: part_of GO:0033554 ! cellular response to stress +relationship: part_of GO:0071229 ! cellular response to acid chemical + +[Term] +id: GO:0097534 +name: lymphoid lineage cell migration +namespace: biological_process +def: "The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage." [GOC:pr, PMID:22342843] +synonym: "lymphoid lineage restricted progenitor cell migration" EXACT [] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0097535 +name: lymphoid lineage cell migration into thymus +namespace: biological_process +def: "The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process." [GOC:cvs, PMID:22342843] +synonym: "lymphoid lineage restricted progenitor cell migration into thymus" EXACT [] +is_a: GO:0097534 ! lymphoid lineage cell migration + +[Term] +id: GO:0097536 +name: thymus epithelium morphogenesis +namespace: biological_process +def: "The process in which the thymus epithelium is generated and organized." [GOC:pr, PMID:22342843] +synonym: "thymic epithelium morphogenesis" EXACT [] +is_a: GO:0002009 ! morphogenesis of an epithelium +relationship: part_of GO:0048538 ! thymus development + +[Term] +id: GO:0097537 +name: Y-shaped link +namespace: cellular_component +def: "A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium." [GOC:cilia, PMID:22653444, PMID:4554367] +synonym: "membrane-microtubule complex" RELATED [] +synonym: "Y-link" RELATED [] +synonym: "Y-link structure" RELATED [] +synonym: "Y-shaped assemblage" RELATED [] +synonym: "Y-shaped fiber" RELATED [] +synonym: "Y-shaped fibre" RELATED [] +synonym: "Y-shaped linker" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0035869 ! ciliary transition zone + +[Term] +id: GO:0097538 +name: ciliary necklace +namespace: cellular_component +def: "A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links." [GOC:cilia, PMID:22653444, PMID:4554367] +synonym: "cilial necklace" EXACT [] +synonym: "cilium necklace" EXACT [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0035869 ! ciliary transition zone +relationship: part_of GO:0060170 ! ciliary membrane + +[Term] +id: GO:0097539 +name: ciliary transition fiber +namespace: cellular_component +def: "A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium)." [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827] +comment: In mammals, ciliary transition fibers comprise at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) (PMID:24469809). +synonym: "centriolar distal appendage" RELATED [PMID:24469809] +synonym: "cilial transition fiber" EXACT [] +synonym: "cilial transition fibre" EXACT [] +synonym: "ciliary transition fibre" EXACT [] +synonym: "cilium transition fiber" EXACT [] +synonym: "cilium transition fibre" EXACT [] +synonym: "distal appendage of basal body" RELATED [GOC:krc] +synonym: "distal appendage of centriole" RELATED [GOC:krc] +synonym: "distal appendage of mother centriole" RELATED [GOC:krc] +synonym: "transition fiber" BROAD [] +synonym: "transition fibre" BROAD [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097540 +name: axonemal central pair +namespace: cellular_component +def: "Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia." [GOC:cilia, GOC:krc, PMID:24283352] +synonym: "axonemal microtubule central pair" EXACT [] +synonym: "axoneme central pair" EXACT [] +synonym: "axoneme microtubule central pair" EXACT [] +synonym: "central pair" BROAD [] +synonym: "central-pair microtubules" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:1990716 ! axonemal central apparatus + +[Term] +id: GO:0097541 +name: axonemal basal plate +namespace: cellular_component +def: "Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure." [GOC:cilia, PMID:23352055, PMID:4554367] +synonym: "axoneme basal plate" EXACT [] +synonym: "basal plate" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0097542 +name: ciliary tip +namespace: cellular_component +def: "Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction." [GOC:cilia, PMID:23970417] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "cilial tip" EXACT [] +synonym: "cilium tip" EXACT [] +synonym: "flagellar tip" EXACT [] +synonym: "flagellum tip" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097543 +name: ciliary inversin compartment +namespace: cellular_component +def: "Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium." [GOC:cilia, PMID:19050042] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "cilial inversin compartment" EXACT [] +synonym: "cilium inversin compartment" EXACT [] +synonym: "flagellar inversin compartment" EXACT [] +synonym: "flagellum inversin compartment" EXACT [] +synonym: "Inv compartment of the cilium" EXACT [] +synonym: "inversin compartment" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097544 +name: ciliary shaft +namespace: cellular_component +def: "The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space." [GOC:cilia, GOC:krc, PMID:19866682] +comment: Note that 'ciliary shaft' is sparingly used in the literature to denote the projecting part of the cilium; many authors would refer to the axoneme instead. However, the definition of GO:0005930 'axoneme' is rather stringent, and the localization of many ciliary proteins would not fit that definition. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "cilial shaft" EXACT [] +synonym: "cilium shaft" EXACT [] +synonym: "flagellar shaft" EXACT [] +synonym: "flagellum shaft" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097545 +name: axonemal outer doublet +namespace: cellular_component +def: "Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium." [GOC:cilia, GOC:krc, GOC:pr, PMID:5044758, PMID:5664206, Wikipedia:Axoneme] +synonym: "axoneme outer doublet" EXACT [] +synonym: "outer doublet" BROAD [] +synonym: "outer-doublet microtubules" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0097546 +name: ciliary base +namespace: cellular_component +def: "Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area." [GOC:cilia, GOC:krc, PMID:22653444] +comment: Due to resolution issues, researchers are often unable to assign protein localization to more specific ciliary compartments such as the basal body, transition fibers or transition zone, and instead refer to 'ciliary base'. The terms GO:0036064 'ciliary basal body', GO:0097539 'ciliary transition fiber' and GO:0035869 'ciliary transition zone' represent strictly defined compartments at the ciliary base and should be used for annotation whenever possible. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. +synonym: "cilial base" EXACT [] +synonym: "cilium base" EXACT [] +synonym: "flagellar base" EXACT [] +synonym: "flagellum base" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0097547 +name: synaptic vesicle protein transport vesicle +namespace: cellular_component +def: "A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270] +comment: This term should not be confused with GO:0008021 'synaptic vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. +synonym: "STV" EXACT [] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0097548 +name: seed abscission +namespace: biological_process +def: "The controlled shedding of a seed." [GOC:lmo] +is_a: GO:0009838 ! abscission + +[Term] +id: GO:0097549 +name: obsolete chromatin organization involved in negative regulation of transcription +namespace: biological_process +alt_id: GO:1903758 +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093] +comment: This term was obsoleted because these it was redundant with other terms: heterochromatin assembly and negative regulation of gene expression, epigenetic. +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription by chromatin organization" EXACT [] +synonym: "negative regulation of transcription from Pol II promoter by histone modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter by histone modification" NARROW [] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global by histone modification" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:0097550 +name: transcription preinitiation complex +namespace: cellular_component +def: "A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription." [GOC:di, PMID:22751016] +synonym: "DNA-templated transcriptional preinitiation complex" EXACT [] +synonym: "PIC" NARROW [] +synonym: "preinitiation complex" NARROW [] +synonym: "transcriptional pre-initiation complex" EXACT [] +synonym: "transcriptional preinitiation complex" EXACT [] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:0097551 +name: mitochondrial double-strand break repair +namespace: biological_process +def: "The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:di, PMID:22214610] +comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. +synonym: "mtDSB repair" EXACT [] +is_a: GO:0006302 ! double-strand break repair + +[Term] +id: GO:0097552 +name: mitochondrial double-strand break repair via homologous recombination +namespace: biological_process +def: "The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:di, PMID:22214610] +comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. +synonym: "mtDSB repair via homologous recombination" EXACT [] +is_a: GO:0000725 ! recombinational repair +is_a: GO:0097551 ! mitochondrial double-strand break repair + +[Term] +id: GO:0097553 +name: calcium ion transmembrane import into cytosol +namespace: biological_process +def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw] +synonym: "calcium transmembrane import into cytosol" BROAD [] +is_a: GO:0060402 ! calcium ion transport into cytosol +is_a: GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:0097554 +name: left anterior flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "left anterior cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097555 +name: right anterior flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "right anterior cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097556 +name: left posteriolateral flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "left posteriolateral cilium" EXACT [] +synonym: "left posterolateral cilium" EXACT [] +synonym: "left posterolateral flagellum" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097557 +name: right posteriolateral flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "right posteriolateral cilium" EXACT [] +synonym: "right posterolateral cilium" EXACT [] +synonym: "right posterolateral flagellum" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097558 +name: left ventral flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "left ventral cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097559 +name: right ventral flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "right ventral cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097560 +name: left caudal flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "left caudal cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097561 +name: right caudal flagellum +namespace: cellular_component +def: "A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "right caudal cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097562 +name: left lateral basal body pair +namespace: cellular_component +def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097563 +name: left middle basal body pair +namespace: cellular_component +def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097564 +name: right lateral basal body pair +namespace: cellular_component +def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097565 +name: right middle basal body pair +namespace: cellular_component +def: "Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097566 +name: left tetrad +namespace: cellular_component +def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097567 +name: right tetrad +namespace: cellular_component +def: "Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally)." [GOC:giardia, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:0097568 +name: median body +namespace: cellular_component +def: "A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc." [GOC:giardia, PMID:5961344] +comment: Note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "parabasal body" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0097569 +name: lateral shield +namespace: cellular_component +def: "Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella." [GOC:giardia, ISBN:9780124260207] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044297 ! cell body + +[Term] +id: GO:0097570 +name: cyst wall +namespace: cellular_component +def: "The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins." [GOC:giardia, PMID:15134259, PMID:2026212, Wikipedia:Microbial_cyst] +is_a: GO:0005618 ! cell wall + +[Term] +id: GO:0097571 +name: left nucleus +namespace: cellular_component +def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0097572 +name: right nucleus +namespace: cellular_component +def: "One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side." [GOC:giardia, ISBN:0-444-81258-X] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +is_a: GO:0005634 ! nucleus + +[Term] +id: GO:0097573 +name: glutathione oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione." [GOC:jd, PMID:18992757] +comment: Note that this activity is different from GO:0015038 'glutathione disulfide oxidoreductase activity'. See PMID:18992757: "Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism". +is_a: GO:0015035 ! protein-disulfide reductase activity + +[Term] +id: GO:0097574 +name: lateral part of cell +namespace: cellular_component +def: "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells." [GOC:pr] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097575 +name: lateral cell cortex +namespace: cellular_component +def: "The region directly beneath the plasma membrane of the lateral portion of the cell." [GOC:mah, PMID:24146635] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0097574 ! lateral part of cell + +[Term] +id: GO:0097576 +name: vacuole fusion +namespace: biological_process +def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, Wikipedia:Vacuole] +is_a: GO:0007033 ! vacuole organization +is_a: GO:0048284 ! organelle fusion + +[Term] +id: GO:0097577 +name: sequestering of iron ion +namespace: biological_process +def: "The process of binding or confining iron ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] +synonym: "iron ion retention" EXACT [] +synonym: "iron ion sequestering" EXACT [] +synonym: "iron ion sequestration" EXACT [] +synonym: "iron ion storage" EXACT [] +synonym: "retention of iron ion" EXACT [] +synonym: "sequestration of iron ion" EXACT [] +synonym: "storage of iron ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0006879 ! cellular iron ion homeostasis + +[Term] +id: GO:0097578 +name: sequestering of copper ion +namespace: biological_process +def: "The process of binding or confining copper ions such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] +synonym: "copper ion retention" EXACT [] +synonym: "copper ion sequestering" EXACT [] +synonym: "copper ion sequestration" EXACT [] +synonym: "copper ion storage" EXACT [] +synonym: "retention of copper ion" EXACT [] +synonym: "sequestration of copper ion" EXACT [] +synonym: "storage of copper ion" EXACT [] +is_a: GO:0006878 ! cellular copper ion homeostasis +is_a: GO:0051238 ! sequestering of metal ion +is_a: GO:0051651 ! maintenance of location in cell + +[Term] +id: GO:0097579 +name: extracellular sequestering of copper ion +namespace: biological_process +def: "The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] +synonym: "extracellular copper ion retention" EXACT [] +synonym: "extracellular copper ion sequestering" EXACT [] +synonym: "extracellular copper ion sequestration" EXACT [] +synonym: "extracellular copper ion storage" EXACT [] +synonym: "extracellular retention of copper ion" EXACT [] +synonym: "extracellular sequestration of copper ion" EXACT [] +synonym: "extracellular storage of copper ion" EXACT [] +is_a: GO:0097578 ! sequestering of copper ion +relationship: part_of GO:0006878 ! cellular copper ion homeostasis + +[Term] +id: GO:0097580 +name: intracellular sequestering of copper ion +namespace: biological_process +def: "The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GOC:mr, PMID:3099306] +synonym: "intracellular copper ion retention" EXACT [] +synonym: "intracellular copper ion sequestering" EXACT [] +synonym: "intracellular copper ion sequestration" EXACT [] +synonym: "intracellular copper ion storage" EXACT [] +synonym: "intracellular retention of copper ion" EXACT [] +synonym: "intracellular sequestration of copper ion" EXACT [] +synonym: "intracellular storage of copper ion" EXACT [] +is_a: GO:0097578 ! sequestering of copper ion +relationship: part_of GO:0006878 ! cellular copper ion homeostasis + +[Term] +id: GO:0097581 +name: lamellipodium organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments." [GOC:als, PMID:16054028] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0097582 +name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex +namespace: cellular_component +def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p." [GOC:jd, PMID:12551906] +synonym: "Pmt1p-Pmt2p complex" NARROW [] +is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex + +[Term] +id: GO:0097583 +name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex +namespace: cellular_component +def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p." [GOC:jd, PMID:12551906] +synonym: "Pmt1p-Pmt3p complex" NARROW [] +is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex + +[Term] +id: GO:0097584 +name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex +namespace: cellular_component +def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p." [GOC:jd, PMID:12551906] +synonym: "Pmt5p-Pmt2p complex" NARROW [] +is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex + +[Term] +id: GO:0097585 +name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex +namespace: cellular_component +def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p." [GOC:jd, PMID:12551906] +synonym: "Pmt5p-Pmt3p complex" NARROW [] +is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex + +[Term] +id: GO:0097586 +name: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex +namespace: cellular_component +def: "A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p." [GOC:bhm, GOC:jd, PMID:12551906] +synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer" EXACT [] +synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex" EXACT [] +synonym: "Pmt4p-Pmt4p complex" NARROW [] +is_a: GO:0031502 ! dolichyl-phosphate-mannose-protein mannosyltransferase complex + +[Term] +id: GO:0097587 +name: MutLgamma complex +namespace: cellular_component +def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3." [GOC:jd, PMID:10570173] +is_a: GO:0032300 ! mismatch repair complex + +[Term] +id: GO:0097588 +name: archaeal or bacterial-type flagellum-dependent cell motility +namespace: biological_process +def: "Cell motility due to movement of bacterial- or archaeal-type flagella." [GOC:cilia, GOC:krc] +comment: Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. This term was added for mapping to the UniProt keyword "flagellar rotation". For manual annotation, please use one of the child terms of GO:0097588 that refer specifically to either archaeal- or bacterial-type flagella. +is_a: GO:0001539 ! cilium or flagellum-dependent cell motility + +[Term] +id: GO:0097589 +name: archaeal-type flagellum +namespace: cellular_component +def: "A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function." [GOC:cilia, GOC:krc, PMID:21265748, PMID:23146836, PMID:23204365, PMID:24330313, Wikipedia:Flagellum#Archaeal] +synonym: "archaeal flagellum" RELATED [] +synonym: "archaella" RELATED [] +synonym: "archaellum" EXACT [] +is_a: GO:0042995 ! cell projection +is_a: GO:0043228 ! non-membrane-bounded organelle + +[Term] +id: GO:0097590 +name: archaeal-type flagellum-dependent cell motility +namespace: biological_process +def: "Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel." [GOC:cilia, GOC:krc, Wikipedia:Flagellum#Archaeal] +synonym: "archaeal-type flagellar cell motility" RELATED [] +is_a: GO:0097588 ! archaeal or bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:0097591 +name: ventral disc lateral crest +namespace: cellular_component +def: "Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet." [GOC:giardia] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "lateral crest" BROAD [] +synonym: "ventral disk lateral crest" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097592 +name: ventral disc overlap zone +namespace: cellular_component +def: "A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself)." [GOC:giardia] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "overlap zone" BROAD [] +synonym: "ventral disk overlap zone" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097593 +name: ventral disc microtubule array +namespace: cellular_component +def: "A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane." [GOC:giardia] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "spiral microtubule array" BROAD [] +synonym: "ventral disc spiral microtubule array" EXACT [] +synonym: "ventral disk microtubule array" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097594 +name: ventral disc dorsal microribbon +namespace: cellular_component +def: "Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons." [GOC:giardia, PMID:11432808] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "dorsal microribbon" BROAD [] +synonym: "dorsal ribbon" BROAD [] +synonym: "microribbon" BROAD [] +synonym: "ventral disk dorsal microribbon" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097595 +name: ventral disc crossbridge +namespace: cellular_component +def: "Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet." [GOC:giardia] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "crossbridge" BROAD [] +synonym: "ventral disk crossbridge" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097596 +name: ventral disc supernumerary microtubule array +namespace: cellular_component +def: "A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage)." [GOC:giardia, ISBN:9780124260207] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "supernumerary microtubule array" BROAD [] +synonym: "ventral disk supernumerary microtubule array" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097597 ! ventral disc + +[Term] +id: GO:0097597 +name: ventral disc +namespace: cellular_component +def: "Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence." [GOC:giardia, ISBN:9780124260207, PMID:11432808, PMID:4777416, PMID:5961344] +comment: Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "adhesive disc" RELATED [] +synonym: "ventral adhesive disc" EXACT [] +synonym: "ventral disk" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0097598 +name: sperm cytoplasmic droplet +namespace: cellular_component +def: "A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted." [GOC:krc, GOC:vesicles, PMID:12672117, PMID:21076437, PMID:23159014] +synonym: "sperm residual cytoplasm" EXACT [] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0097599 +name: xylanase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues." [GOC:jh2, ISBN:81-7736-269-0] +synonym: "xylosidase activity" RELATED [] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0097600 +name: exoxylanase activity +namespace: molecular_function +def: "A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains." [GOC:jh2, ISBN:81-7736-269-0, PMID:16535010] +is_a: GO:0097599 ! xylanase activity + +[Term] +id: GO:0097601 +name: retina blood vessel maintenance +namespace: biological_process +def: "A retina homeostatic process preventing the degeneration of a retina blood vessel." [GOC:jh2, PMID:23093773] +synonym: "maintenance of choriocapillaris" NARROW [] +synonym: "maintenance of retina blood vessel" EXACT [] +synonym: "maintenance of retinal blood vessel" EXACT [] +is_a: GO:0001895 ! retina homeostasis + +[Term] +id: GO:0097602 +name: cullin family protein binding +namespace: molecular_function +def: "Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3)." [GOC:ha, InterPro:IPR016158, PMID:18698375] +synonym: "cullin binding" NARROW [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097603 +name: temperature-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824] +synonym: "heat-activated ion channel activity" NARROW [] +synonym: "temperature gated ion channel activity" EXACT [] +synonym: "temperature-activated ion channel activity" EXACT [] +synonym: "temperature-dependent ion channel activity" EXACT [] +is_a: GO:0005216 ! ion channel activity +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0097604 +name: temperature-gated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism)." [GOC:ha, GOC:pr, PMID:23027824] +synonym: "heat-activated cation channel activity" NARROW [] +synonym: "temperature gated cation channel activity" EXACT [] +synonym: "temperature-activated cation channel activity" EXACT [] +synonym: "temperature-dependent cation channel activity" EXACT [] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0097603 ! temperature-gated ion channel activity + +[Term] +id: GO:0097605 +name: obsolete regulation of nuclear envelope permeability +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] +comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. +synonym: "regulation of nuclear membrane permeability" RELATED [] +is_obsolete: true + +[Term] +id: GO:0097606 +name: obsolete positive regulation of nuclear envelope permeability +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] +comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. +synonym: "positive regulation of nuclear membrane permeability" RELATED [] +is_obsolete: true + +[Term] +id: GO:0097607 +name: obsolete negative regulation of nuclear envelope permeability +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the nuclear envelope." [GOC:pr] +comment: The reason for obsoletion is that the nuclear envelope is quite permeable, so there is no cellular process to regulate it. +synonym: "negative regulation of nuclear membrane permeability" RELATED [] +is_obsolete: true + +[Term] +id: GO:0097608 +name: transverse flagellum +namespace: cellular_component +def: "A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. +synonym: "transverse cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097609 +name: longitudinal flagellum +namespace: cellular_component +def: "A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. +synonym: "longitudinal cilium" EXACT [] +is_a: GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097610 +name: cell surface furrow +namespace: cellular_component +def: "A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates." [GOC:pr] +synonym: "cell surface groove" RELATED [] +synonym: "furrow" BROAD [] +synonym: "groove" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009986 ! cell surface + +[Term] +id: GO:0097611 +name: dinoflagellate cingulum +namespace: cellular_component +def: "A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "cingulum" BROAD [] +synonym: "girdle" RELATED [] +synonym: "transverse groove" RELATED [] +is_a: GO:0097610 ! cell surface furrow + +[Term] +id: GO:0097612 +name: dinoflagellate sulcus +namespace: cellular_component +def: "A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). +synonym: "longitudinal furrow" RELATED [] +synonym: "longitudinal groove" RELATED [] +synonym: "sulcus" BROAD [] +is_a: GO:0097610 ! cell surface furrow + +[Term] +id: GO:0097613 +name: dinoflagellate epicone +namespace: cellular_component +def: "The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "epicone" BROAD [] +synonym: "episome" RELATED [] +synonym: "epitheca" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097614 +name: dinoflagellate hypocone +namespace: cellular_component +def: "The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "hypocone" BROAD [] +synonym: "hyposome" RELATED [] +synonym: "hypotheca" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097615 +name: modulation by host of symbiont type IV pilus-dependent motility +namespace: biological_process +def: "The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568] +synonym: "modulation by host of bacterial type IV pilus-dependent motility" EXACT [] +is_a: GO:0051851 ! modulation by host of symbiont process + +[Term] +id: GO:0097616 +name: positive regulation by host of symbiont type IV pilus-dependent motility +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:als, PMID:12037568] +synonym: "positive regulation by host of bacterial type IV pilus-dependent motility" EXACT [] +is_a: GO:0097615 ! modulation by host of symbiont type IV pilus-dependent motility + +[Term] +id: GO:0097618 +name: dinoflagellate sulcal notch +namespace: cellular_component +def: "A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). The term 'sulcal notch' appears mostly in older literature; more recently, indication of a bilobed hypocone is used to express the same. +synonym: "dinoflagellate sulcus notch" EXACT [] +synonym: "sulcal notch" RELATED [] +is_a: GO:0097612 ! dinoflagellate sulcus + +[Term] +id: GO:0097619 +name: PTEX complex +namespace: cellular_component +def: "A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components." [GOC:pr, PMID:19536257, PMID:25043010, PMID:25043043] +synonym: "Plasmodium translocon of exported proteins" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane + +[Term] +id: GO:0097620 +name: (R)-mandelate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor." [GOC:pr, PMID:1731758, RHEA:43112] +comment: In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate. +synonym: "D-mandelate dehydrogenase activity" EXACT [] +xref: RHEA:43112 +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0097621 +name: monoamine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2." [GOC:pr, RHEA:26414] +comment: Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC:1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. +synonym: "amine:oxygen oxidoreductase (deaminating) activity" EXACT [] +xref: EC:1.4.3.4 +xref: RHEA:26414 +is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor + +[Term] +id: GO:0097622 +name: cytoplasmic translational elongation through polyproline stretches +namespace: biological_process +def: "The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm." [GOC:mcc, PMID:24923804] +is_a: GO:0002182 ! cytoplasmic translational elongation + +[Term] +id: GO:0097623 +name: potassium ion export across plasma membrane +namespace: biological_process +alt_id: GO:0071435 +alt_id: GO:0098668 +def: "The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:11932440] +synonym: "potassium export" BROAD [GOC:mah] +synonym: "potassium export across plasma membrane" EXACT [] +synonym: "potassium ion export" BROAD [] +synonym: "potassium ion export from cell" EXACT [] +is_a: GO:0070839 ! metal ion export +is_a: GO:0071805 ! potassium ion transmembrane transport +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0097624 +name: UDP-galactose transmembrane import into Golgi lumen +namespace: biological_process +def: "The directed movement of UDP-galactose into the Golgi lumen across the Golgi membrane." [GOC:vw, PMID:11378902] +synonym: "UDP-galactose import into Golgi lumen" BROAD [] +is_a: GO:0072334 ! UDP-galactose transmembrane transport + +[Term] +id: GO:0097625 +name: low-affinity basic amino acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:pr] +synonym: "low affinity basic amino acid transmembrane transporter activity" EXACT [] +is_a: GO:0015174 ! basic amino acid transmembrane transporter activity + +[Term] +id: GO:0097626 +name: low-affinity L-arginine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:krc, PMID:8195186] +synonym: "low affinity L-arginine transmembrane transporter activity" EXACT [] +is_a: GO:0061459 ! L-arginine transmembrane transporter activity +is_a: GO:0097625 ! low-affinity basic amino acid transmembrane transporter activity + +[Term] +id: GO:0097627 +name: high-affinity L-ornithine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:krc, PMID:8195186] +synonym: "high affinity L-ornithine transmembrane transporter activity" EXACT [] +is_a: GO:0000064 ! L-ornithine transmembrane transporter activity + +[Term] +id: GO:0097628 +name: distal tip cell migration +namespace: biological_process +def: "The orderly movement of a distal tip cell." [CL:0000661, GOC:mm2, PMID:24968003] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0097629 +name: extrinsic component of omegasome membrane +namespace: cellular_component +def: "The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf, PMID:18725538, PMID:24591649] +synonym: "extrinsic to omegasome membrane" EXACT [] +synonym: "omegasome peripheral membrane" RELATED [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:1903349 ! omegasome membrane + +[Term] +id: GO:0097630 +name: intrinsic component of omegasome membrane +namespace: cellular_component +def: "The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf, PMID:18725538, PMID:24591649] +synonym: "intrinsic to omegasome membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:1903349 ! omegasome membrane + +[Term] +id: GO:0097631 +name: integral component of omegasome membrane +namespace: cellular_component +def: "The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf, PMID:18725538, PMID:24591649] +synonym: "integral to omegasome membrane" NARROW [] +synonym: "omegasome integral membrane protein" RELATED [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0097630 ! intrinsic component of omegasome membrane + +[Term] +id: GO:0097632 +name: extrinsic component of phagophore assembly site membrane +namespace: cellular_component +def: "The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:mf] +synonym: "extrinsic component of pre-autophagosomal structure membrane" NARROW [] +synonym: "extrinsic to phagophore assembly site membrane" EXACT [] +synonym: "phagophore assembly site peripheral membrane" RELATED [] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0034045 ! phagophore assembly site membrane + +[Term] +id: GO:0097633 +name: intrinsic component of phagophore assembly site membrane +namespace: cellular_component +def: "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:mf] +synonym: "intrinsic to phagophore assembly site membrane" NARROW [] +is_a: GO:0031224 ! intrinsic component of membrane +relationship: part_of GO:0034045 ! phagophore assembly site membrane + +[Term] +id: GO:0097634 +name: integral component of phagophore assembly site membrane +namespace: cellular_component +def: "The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mf] +synonym: "integral to phagophore assembly site membrane" NARROW [] +synonym: "phagophore assembly site integral membrane protein" RELATED [] +is_a: GO:0016021 ! integral component of membrane +is_a: GO:0097633 ! intrinsic component of phagophore assembly site membrane + +[Term] +id: GO:0097635 +name: extrinsic component of autophagosome membrane +namespace: cellular_component +def: "The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +synonym: "autophagic vacuole peripheral membrane" RELATED [] +synonym: "extrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy] +synonym: "extrinsic to autophagic vacuole membrane" EXACT [] +is_a: GO:0000306 ! extrinsic component of vacuolar membrane +relationship: part_of GO:0000421 ! autophagosome membrane + +[Term] +id: GO:0097636 +name: intrinsic component of autophagosome membrane +namespace: cellular_component +def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:autophagy, GOC:mf] +synonym: "intrinsic component of autophagic vacuole membrane" EXACT [GOC:autophagy] +synonym: "intrinsic to autophagic vacuole membrane" NARROW [] +is_a: GO:0031310 ! intrinsic component of vacuolar membrane +relationship: part_of GO:0000421 ! autophagosome membrane + +[Term] +id: GO:0097637 +name: integral component of autophagosome membrane +namespace: cellular_component +def: "The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:autophagy, GOC:mf] +synonym: "autophagic vacuole integral membrane protein" RELATED [] +synonym: "integral component of autophagic vacuole membrane" EXACT [GOC:autophagy] +synonym: "integral to autophagic vacuole membrane" NARROW [] +is_a: GO:0031166 ! integral component of vacuolar membrane +is_a: GO:0097636 ! intrinsic component of autophagosome membrane + +[Term] +id: GO:0097638 +name: L-arginine import across plasma membrane +namespace: biological_process +alt_id: GO:0090467 +alt_id: GO:1902765 +def: "The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] +synonym: "arginine import" BROAD [] +synonym: "L-arginine import into cell" EXACT [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:0097639 +name: L-lysine import across plasma membrane +namespace: biological_process +alt_id: GO:1903410 +def: "The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] +synonym: "L-lysine import into cell" EXACT [] +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:1903401 ! L-lysine transmembrane transport + +[Term] +id: GO:0097640 +name: L-ornithine import across plasma membrane +namespace: biological_process +alt_id: GO:1903411 +def: "The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] +synonym: "L-ornithine import into cell" EXACT [] +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:1903352 ! L-ornithine transmembrane transport + +[Term] +id: GO:0097641 +name: alpha-ketoglutarate-dependent xanthine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate." [GOC:vw, PMID:15948966, PMID:17429948, RHEA:43120] +synonym: "2-oxoglutarate-dependent xanthine dioxygenase activity" EXACT [] +synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity" RELATED [] +synonym: "alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity" RELATED [] +xref: RHEA:43120 +is_a: GO:0051213 ! dioxygenase activity + +[Term] +id: GO:0097642 +name: calcitonin family receptor activity +namespace: molecular_function +def: "Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity." [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:0008528 ! G protein-coupled peptide receptor activity + +[Term] +id: GO:0097643 +name: amylin receptor activity +namespace: molecular_function +def: "Combining with amylin to initiate a change in cell activity." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:0097642 ! calcitonin family receptor activity + +[Term] +id: GO:0097644 +name: calcitonin family binding +namespace: molecular_function +def: "Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs))." [GOC:bhm, InterPro:IPR021116, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0097645 +name: amylin binding +namespace: molecular_function +def: "Binding to amylin." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:0097644 ! calcitonin family binding + +[Term] +id: GO:0097646 +name: calcitonin family receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) combining with a calcitonin family receptor on the surface of the target cell. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] +synonym: "calcitonin family receptor signalling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0097647 +name: amylin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell." [GOC:bhm, PMID:10871296, PMID:12037140, PMID:18687416] +synonym: "amilyn receptor signalling pathway" EXACT [] +is_a: GO:0097646 ! calcitonin family receptor signaling pathway + +[Term] +id: GO:0097648 +name: G protein-coupled receptor complex +namespace: cellular_component +def: "A protein complex that contains G protein-coupled receptors." [GOC:bhm] +synonym: "G-protein coupled receptor complex" EXACT [] +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:0097649 +name: A axonemal microtubule +namespace: cellular_component +def: "A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule." [GOC:cilia, ISBN:0716731363] +synonym: "A tubule" BROAD [] +is_a: GO:0005879 ! axonemal microtubule +relationship: part_of GO:0097545 ! axonemal outer doublet + +[Term] +id: GO:0097650 +name: B axonemal microtubule +namespace: cellular_component +def: "An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet." [GOC:cilia, ISBN:0716731363] +synonym: "B tubule" BROAD [] +is_a: GO:0005879 ! axonemal microtubule +relationship: part_of GO:0097545 ! axonemal outer doublet + +[Term] +id: GO:0097651 +name: phosphatidylinositol 3-kinase complex, class I +namespace: cellular_component +def: "A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488] +synonym: "class I phosphatidylinositol 3-kinase complex" EXACT [] +synonym: "class I PI3K complex" EXACT [] +is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex + +[Term] +id: GO:0097652 +name: phosphatidylinositol 3-kinase complex, class II +namespace: cellular_component +def: "A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast." [GOC:ha, PMID:24587488] +synonym: "class II phosphatidylinositol 3-kinase complex" EXACT [] +synonym: "class II PI3K complex" EXACT [] +is_a: GO:0005942 ! phosphatidylinositol 3-kinase complex + +[Term] +id: GO:0097653 +name: unencapsulated part of cell +namespace: cellular_component +def: "The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures." [GOC:curators] +synonym: "non-encapsulated part of cell" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0097654 +name: platelet SNARE complex +namespace: cellular_component +def: "A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4." [GOC:bhm, PMID:12130530, PMID:19450911] +is_a: GO:0031201 ! SNARE complex + +[Term] +id: GO:0097655 +name: serpin family protein binding +namespace: molecular_function +def: "Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors." [GOC:mr, InterPro:IPR000215, PMID:16737556] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097656 +name: cell-cell self recognition +namespace: biological_process +def: "A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development." [GOC:pf, PMID:21700835, PMID:23910661] +comment: Examples are the membrane proteins TgrB1 and TgrC1 in the social amoeba Dictyostelium discoideum. +synonym: "kin discrimination" RELATED [] +synonym: "kin recognition" BROAD [] +synonym: "self recognition" BROAD [] +is_a: GO:0009988 ! cell-cell recognition + +[Term] +id: GO:0097657 +name: 3',5'-nucleotide bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate." [GOC:jh2, PMID:24401123, RHEA:43532] +xref: EC:3.1.3.97 +xref: RHEA:43532 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0097658 +name: Asi complex +namespace: cellular_component +def: "A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p." [GOC:mcc, PMID:25236469] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005637 ! nuclear inner membrane + +[Term] +id: GO:0097659 +name: nucleic acid-templated transcription +namespace: biological_process +def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +subset: goslim_mouse +is_a: GO:0032774 ! RNA biosynthetic process +relationship: part_of GO:0010467 ! gene expression + +[Term] +id: GO:0097660 +name: SCF-Cdc4 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:9346238] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097661 +name: SCF-Ctf13 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097662 +name: SCF-Das1 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097663 +name: SCF-Dia2/Pof3 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097664 +name: SCF-Grr1/Pof2 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe)." [GOC:jd, GOC:vw, PMID:10213692, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097665 +name: SCF-Mdm30 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097666 +name: SCF-Met30/Pof1 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe)." [GOC:jd, GOC:vw, PMID:15147268, PMID:9499404] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097667 +name: SCF-Rcy1/Pof6 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097668 +name: SCF-Saf1/Pof9 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe)." [GOC:jd, GOC:vw, PMID:11283612, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097669 +name: SCF-Skp2 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097670 +name: SCF-Ufo1/Pof10 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097671 +name: SCF-YDR131C ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097672 +name: SCF-Pof5 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] +synonym: "SCF-YDR306C ubiquitin ligase complex" RELATED [] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097673 +name: SCF-Ucc1 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:14747994, PMID:25982115] +synonym: "SCF-YLR224W ubiquitin ligase complex" EXACT [PMID:14747994] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097674 +name: SCF-YLR352W ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae." [GOC:jd, GOC:vw, PMID:19882662] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097675 +name: SCF-Hrt3/Pof7 ubiquitin ligase complex +namespace: cellular_component +def: "An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe)." [GOC:jd, GOC:vw, PMID:14747994, PMID:15147268] +is_a: GO:0019005 ! SCF ubiquitin ligase complex + +[Term] +id: GO:0097676 +name: histone H3-K36 dimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone." [GOC:lb, PMID:21187428] +is_a: GO:0010452 ! histone H3-K36 methylation +is_a: GO:0018027 ! peptidyl-lysine dimethylation + +[Term] +id: GO:0097677 +name: STAT family protein binding +namespace: molecular_function +def: "Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses." [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978] +synonym: "signal transducers and activators of transcription family protein binding" EXACT [] +is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding + +[Term] +id: GO:0097678 +name: SOCS family protein binding +namespace: molecular_function +def: "Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions." [GOC:mr, InterPro:IPR028413, PMID:23885323, PMID:24705897] +synonym: "suppressor of cytokine signaling family protein binding" EXACT [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0097680 +name: double-strand break repair via classical nonhomologous end joining +namespace: biological_process +def: "An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining)." [GOC:rph, PMID:18584027] +synonym: "C-NHEJ" RELATED [] +synonym: "canonical nonhomologous end joining" EXACT [] +is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:0097681 +name: double-strand break repair via alternative nonhomologous end joining +namespace: biological_process +def: "An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment." [GOC:rph, PMID:18584027, PMID:21655080, Wikipedia:Microhomology-mediated_end_joining] +synonym: "A-NHEJ" RELATED [] +synonym: "alt-NHEJ" RELATED [] +synonym: "double-strand break repair via microhomology-mediated end joining" EXACT [] +synonym: "MMEJ" RELATED [] +is_a: GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:0097682 +name: intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:ha, PMID:24375408] +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0097683 +name: dinoflagellate apex +namespace: cellular_component +def: "The anterior most point of a dinoflagellate epicone." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "apex" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097613 ! dinoflagellate epicone + +[Term] +id: GO:0097684 +name: dinoflagellate antapex +namespace: cellular_component +def: "The anterior most point of a dinoflagellate hypocone." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "antapex" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097614 ! dinoflagellate hypocone + +[Term] +id: GO:0097685 +name: dinoflagellate apical groove +namespace: cellular_component +def: "A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex." [GOC:at, http://tolweb.org/Dinoflagellates/2445, http://www.sms.si.edu/irlspec/Phyl_Dinofl_Glossary.htm, ISBN:0632009152, Wikipedia:Dinoflagellate#Morphology] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +synonym: "apical groove" BROAD [] +is_a: GO:0097610 ! cell surface furrow +relationship: part_of GO:0097613 ! dinoflagellate epicone + +[Term] +id: GO:0097686 +name: dinoflagellate apical horn +namespace: cellular_component +def: "A horn-shaped dinoflagellate apex found in thecate species." [GOC:at, http://species-identification.org] +is_a: GO:0097683 ! dinoflagellate apex + +[Term] +id: GO:0097687 +name: dinoflagellate antapical horn +namespace: cellular_component +def: "A horn-shaped dinoflagellate antapex found in thecate species." [GOC:at, http://species-identification.org] +is_a: GO:0097684 ! dinoflagellate antapex + +[Term] +id: GO:0097688 +name: glutamate receptor clustering +namespace: biological_process +def: "The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane." [GOC:krc, PMID:19723286] +synonym: "glutamatergic receptor clustering" EXACT [] +is_a: GO:0072578 ! neurotransmitter-gated ion channel clustering + +[Term] +id: GO:0097690 +name: iron ion transmembrane transporter inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an iron ion transmembrane transporter." [GOC:BHF, GOC:kom, PMID:15514116] +comment: An example of this is human hepcidin (UniProt symbol P81172), which regulates iron transport out of cells (see PMID:15514116). +synonym: "iron channel inhibitor activity" EXACT [] +is_a: GO:0140678 ! molecular function inhibitor activity + +[Term] +id: GO:0097691 +name: bacterial extracellular vesicle +namespace: cellular_component +def: "Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells." [GOC:aa, PMID:25704309] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:0097692 +name: histone H3-K4 monomethylation +namespace: biological_process +def: "The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone." [GOC:jh2, PMID:26320581] +is_a: GO:0051568 ! histone H3-K4 methylation + +[Term] +id: GO:0097693 +name: ocelloid +namespace: cellular_component +def: "Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids." [GOC:ar, PMID:26131935] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0097694 +name: establishment of RNA localization to telomere +namespace: biological_process +def: "The directed movement of RNA to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433] +synonym: "establishment of RNA localisation to telomere" EXACT [] +is_a: GO:0051236 ! establishment of RNA localization + +[Term] +id: GO:0097695 +name: establishment of protein-containing complex localization to telomere +namespace: biological_process +def: "The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome." [GOC:BHF, GOC:BHF_telomere, GOC:rph, PMID:26586433] +synonym: "establishment of macromolecular complex localisation to telomere" EXACT [] +synonym: "establishment of macromolecular complex localization to telomere" RELATED [] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051234 ! establishment of localization +relationship: part_of GO:0070727 ! cellular macromolecule localization + +[Term] +id: GO:0097696 +name: receptor signaling pathway via STAT +namespace: biological_process +def: "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:rjd, PMID:21534947, PMID:24587195] +comment: In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins. +synonym: "kinase activated-STAT cascade" EXACT [] +synonym: "kinase-STAT cascade" EXACT [] +synonym: "STAT signalling pathway" EXACT [] +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:0097697 +name: tRNA 5-carboxymethoxyuridine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule." [GOC:imk, PMID:26681692] +is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity + +[Term] +id: GO:0097698 +name: telomere maintenance via base-excision repair +namespace: biological_process +def: "A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:24703901] +is_a: GO:0006284 ! base-excision repair +is_a: GO:0043247 ! telomere maintenance in response to DNA damage + +[Term] +id: GO:0097699 +name: vascular endothelial cell response to fluid shear stress +namespace: biological_process +def: "Any response to fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +synonym: "blood vessel endothelial cell response to fluid shear stress" EXACT [] +is_a: GO:0071498 ! cellular response to fluid shear stress + +[Term] +id: GO:0097700 +name: vascular endothelial cell response to laminar fluid shear stress +namespace: biological_process +def: "Any response to laminar fluid shear stress in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +synonym: "blood vessel endothelial cell response to laminar fluid shear stress" EXACT [] +is_a: GO:0071499 ! cellular response to laminar fluid shear stress +is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress + +[Term] +id: GO:0097701 +name: response to pulsatile fluid shear stress +namespace: biological_process +def: "Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +is_a: GO:0034405 ! response to fluid shear stress + +[Term] +id: GO:0097702 +name: response to oscillatory fluid shear stress +namespace: biological_process +def: "Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +is_a: GO:0034405 ! response to fluid shear stress + +[Term] +id: GO:0097703 +name: cellular response to pulsatile fluid shear stress +namespace: biological_process +def: "Any response to pulsatile fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +is_a: GO:0071498 ! cellular response to fluid shear stress +is_a: GO:0097701 ! response to pulsatile fluid shear stress + +[Term] +id: GO:0097704 +name: cellular response to oscillatory fluid shear stress +namespace: biological_process +def: "Any response to oscillatory fluid shear stress that occurs at the level of a cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +is_a: GO:0071498 ! cellular response to fluid shear stress +is_a: GO:0097702 ! response to oscillatory fluid shear stress + +[Term] +id: GO:0097705 +name: vascular endothelial cell response to pulsatile fluid shear stress +namespace: biological_process +def: "Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +synonym: "blood vessel endothelial cell response to pulsatile fluid shear stress" EXACT [] +is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress +is_a: GO:0097703 ! cellular response to pulsatile fluid shear stress + +[Term] +id: GO:0097706 +name: vascular endothelial cell response to oscillatory fluid shear stress +namespace: biological_process +def: "Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:21768538] +synonym: "blood vessel endothelial cell response to oscillatory fluid shear stress" EXACT [] +is_a: GO:0097699 ! vascular endothelial cell response to fluid shear stress +is_a: GO:0097704 ! cellular response to oscillatory fluid shear stress + +[Term] +id: GO:0097707 +name: ferroptosis +namespace: biological_process +def: "A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes." [GOC:mtg_apoptosis, PMID:25236395, PMID:26794443] +synonym: "iron-dependent programmed cell death" RELATED [] +is_a: GO:0012501 ! programmed cell death + +[Term] +id: GO:0097708 +name: intracellular vesicle +namespace: cellular_component +def: "Any vesicle that is part of the intracellular region." [GOC:vesicles] +is_a: GO:0031982 ! vesicle +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0097709 +name: connective tissue replacement +namespace: biological_process +def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared." [GOC:bc, GOC:BHF, GOC:BHF_miRNA, PMID:25590961] +is_a: GO:0048771 ! tissue remodeling + +[Term] +id: GO:0097710 +name: viral terminase, small subunit +namespace: cellular_component +def: "The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit." [GOC:ch, GOC:jh2, PMID:18687036] +comment: This term should only be used when the small subunit consists of more than one polypeptide. +synonym: "virus terminase, small subunit" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0043493 ! viral terminase complex + +[Term] +id: GO:0097711 +name: ciliary basal body-plasma membrane docking +namespace: biological_process +def: "The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane." [GOC:cilia, PMID:13978319, PMID:23348840, PMID:23530209, PMID:25686250, PMID:26981235, Reactome:R-HSA-5620912.1] +comment: Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. +synonym: "anchoring of the basal body to the plasma membrane" RELATED [] +synonym: "ciliary basal body docking" EXACT [] +xref: Reactome:R-HSA-5620912.1 +is_a: GO:0140056 ! organelle localization by membrane tethering +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:0097712 +name: vesicle targeting, trans-Golgi to periciliary membrane compartment +namespace: biological_process +def: "The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:cilia, PMID:20106869, PMID:23351793, PMID:24814148, PMID:26485645, Reactome:R-HSA-5620920.1] +is_a: GO:0048199 ! vesicle targeting, to, from or within Golgi +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:0097713 +name: dolichol-phosphate-mannose synthase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of dolichol-phosphate-mannose synthase." [GOC:vw, PMID:10835346] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:0097714 +name: response to viscosity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0097715 +name: cellular response to viscosity +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [GOC:sl, PMID:7061416] +is_a: GO:0071214 ! cellular response to abiotic stimulus +is_a: GO:0097714 ! response to viscosity + +[Term] +id: GO:0097716 +name: copper ion transport across blood-brain barrier +namespace: biological_process +def: "The directed movement of copper (Cu) ions passing through the blood-brain barrier." [GOC:sl, PMID:24614235] +synonym: "copper ion transport across BBB" RELATED [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0150104 ! transport across blood-brain barrier + +[Term] +id: GO:0097717 +name: copper ion transport across blood-cerebrospinal fluid barrier +namespace: biological_process +def: "The directed movement of copper (Cu) ions passing through the blood-cerebrospinal fluid barrier." [GOC:sl, PMID:24614235] +synonym: "copper ion transport across BCB" RELATED [] +synonym: "copper ion transport across BCSFB" EXACT [] +synonym: "copper ion transport across blood-CSF barrier" EXACT [] +synonym: "copper ion transport across blood/cerebrospinal fluid barrier" EXACT [] +synonym: "copper ion transport across blood/CSF barrier" EXACT [] +is_a: GO:0006825 ! copper ion transport +is_a: GO:0150195 ! transport across blood-cerebrospinal fluid barrier + +[Term] +id: GO:0097718 +name: disordered domain specific binding +namespace: molecular_function +def: "Binding to a disordered domain of a protein." [GOC:gg, PMID:11746698] +synonym: "disordered protein domain specific binding" RELATED [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0097719 +name: neural tissue regeneration +namespace: biological_process +def: "The regrowth of neural tissue following its loss or destruction." [Wikipedia:Neuroregeneration] +synonym: "neuroregeneration" RELATED [] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:0097720 +name: calcineurin-mediated signaling +namespace: biological_process +def: "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544] +synonym: "calcineurin signaling" RELATED [] +synonym: "calcineurin-mediated signalling" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling + +[Term] +id: GO:0097721 +name: ciliary vesicle +namespace: cellular_component +def: "A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle." [GOC:cilia, PMID:13978319, PMID:25686250] +synonym: "CV" RELATED [PMID:2568625] +synonym: "primary ciliary vesicle" EXACT [PMID:20427320] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0097722 +name: sperm motility +namespace: biological_process +def: "Any process involved in the controlled movement of a sperm cell." [GOC:cilia, GOC:krc] +subset: gocheck_do_not_annotate +synonym: "sperm movement" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0048870 ! cell motility + +[Term] +id: GO:0097723 +name: amoeboid sperm motility +namespace: biological_process +def: "Any process involved in the controlled movement of an amoeboid sperm cell." [GOC:cilia, GOC:krc] +synonym: "ameboid sperm motility" EXACT [] +synonym: "ameboid sperm movement" EXACT [] +synonym: "amoeboid sperm movement" EXACT [] +is_a: GO:0097722 ! sperm motility + +[Term] +id: GO:0097725 +name: histone H3-K79 dimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone." [GOC:hbye, PMID:27541139] +synonym: "histone H3 K79 dimethylation" EXACT [] +synonym: "histone lysine H3 K79 dimethylation" EXACT [] +is_a: GO:0018027 ! peptidyl-lysine dimethylation +is_a: GO:0034729 ! histone H3-K79 methylation + +[Term] +id: GO:0097726 +name: LEM domain binding +namespace: molecular_function +def: "Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)." [GOC:rz, InterPro:IPR003887, PMID:22399800] +synonym: "lamina-associated polypeptide, emerin, MAN1 domain binding" EXACT [] +synonym: "LAP2, emerin, MAN1 domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0097727 +name: blepharoplast +namespace: cellular_component +def: "An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell." [GOC:cilia, GOC:tb, PMID:22691130, PMID:25047614] +comment: The blepharoplast should not be confused with a basal body; rather, it acts as the precursor assembly zone for multiple basal bodies. +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0097728 +name: 9+0 motile cilium +namespace: cellular_component +def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:10330409, PMID:22118931] +comment: This type of cilia may be present in solitary (classic nodal cilia in embryonic nodes) or in multiple copies (e.g. in the choroid plexus epithelium). +synonym: "motile 9+0 cilium" EXACT [] +synonym: "nodal cilium" NARROW [] +is_a: GO:0031514 ! motile cilium + +[Term] +id: GO:0097729 +name: 9+2 motile cilium +namespace: cellular_component +def: "A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:22118931] +comment: This type of cilia may be present in solitary (so-called flagella, e.g. in sperm) or in multiple copies (so-called conventional motile cilia, e.g. in tracheal epithelium, ependyma or oviduct epithelium). +synonym: "conventional motile cilium" NARROW [] +synonym: "motile 9+2 cilium" EXACT [] +synonym: "sperm flagellum" NARROW [] +is_a: GO:0031514 ! motile cilium + +[Term] +id: GO:0097730 +name: non-motile cilium +namespace: cellular_component +alt_id: GO:0031513 +def: "A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] +synonym: "immotile cilium" EXACT [] +synonym: "immotile primary cilium" RELATED [] +synonym: "nonmotile cilium" EXACT [] +synonym: "nonmotile primary cilia" RELATED [] +synonym: "nonmotile primary cilium" RELATED [] +synonym: "sensory cilium" RELATED [] +is_a: GO:0005929 ! cilium + +[Term] +id: GO:0097731 +name: 9+0 non-motile cilium +namespace: cellular_component +def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme)." [GOC:cilia, PMID:22118931] +comment: This type of cilia may be present in solitary (authentic primary cilia in many cell types) or in multiple copies (e.g. in Grueneberg ganglion neurons). +synonym: "9+0 immotile cilium" EXACT [] +synonym: "non-motile 9+0 cilium" EXACT [] +synonym: "primary cilium" NARROW [] +is_a: GO:0097730 ! non-motile cilium + +[Term] +id: GO:0097732 +name: 9+2 non-motile cilium +namespace: cellular_component +def: "A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme)." [GOC:cilia, PMID:21307074, PMID:22118931] +comment: This type of cilia may be present in solitary (e.g. in inner hair cells) or in multiple copies (e.g. in olfactory neurons). +synonym: "9+2 immotile cilium" RELATED [] +synonym: "non-motile 9+2 cilium" EXACT [] +is_a: GO:0097730 ! non-motile cilium + +[Term] +id: GO:0097733 +name: photoreceptor cell cilium +namespace: cellular_component +def: "A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment." [GOC:cilia, Wikipedia:Photoreceptor_cell#Histology] +synonym: "photoreceptor cilium" EXACT [] +is_a: GO:0043005 ! neuron projection +is_a: GO:0097731 ! 9+0 non-motile cilium + +[Term] +id: GO:0097734 +name: extracellular exosome biogenesis +namespace: biological_process +def: "The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:bf, GOC:PARL, PMID:19442504, PMID:25392495] +synonym: "exosome assembly or secretion" EXACT [] +synonym: "exosome biogenesis" EXACT [] +synonym: "exosome production" EXACT [] +synonym: "ILV assembly" RELATED [] +synonym: "intraluminal vesicle assembly" RELATED [] +is_a: GO:0140112 ! extracellular vesicle biogenesis + +[Term] +id: GO:0097735 +name: DIM/DIP cell wall layer +namespace: cellular_component +def: "A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds." [GOC:pr] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009275 ! Gram-positive-bacterium-type cell wall + +[Term] +id: GO:0097736 +name: aerial mycelium formation +namespace: biological_process +def: "The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae." [GOC:di, PMID:12832397] +synonym: "aerial hyphal growth" RELATED [] +synonym: "fertile mycelium formation" RELATED [] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0097737 +name: acquisition of mycelium reproductive competence +namespace: biological_process +def: "A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium." [GOC:di, PMID:23864594] +synonym: "mycelium developmental competence" RELATED [] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0097738 +name: substrate mycelium formation +namespace: biological_process +def: "The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate." [GOC:di, PMID:10021365] +is_a: GO:0019954 ! asexual reproduction +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0097739 +name: negative regulation of ferrichrome biosynthetic process in response to iron +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus." [GOC:al] +is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process +relationship: part_of GO:0071281 ! cellular response to iron ion + +[Term] +id: GO:0097740 +name: paraflagellar rod +namespace: cellular_component +def: "A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling." [GOC:cilia, PMID:19879876, PMID:26199333, PMID:26688619] +synonym: "PFR" RELATED [] +is_a: GO:0099080 ! supramolecular complex +relationship: part_of GO:0097729 ! 9+2 motile cilium + +[Term] +id: GO:0097741 +name: mastigoneme +namespace: cellular_component +def: "A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum." [GOC:cilia, PMID:943397, Wikipedia:Mastigoneme] +is_a: GO:0099080 ! supramolecular complex +relationship: part_of GO:0031514 ! motile cilium + +[Term] +id: GO:0097742 +name: de novo centriole assembly +namespace: biological_process +def: "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects." [GOC:cilia, PMID:25047614, PMID:25291643] +synonym: "acentriolar basal body biogenesis" RELATED [] +synonym: "de novo basal body amplification" RELATED [] +synonym: "de novo basal body assembly" RELATED [] +synonym: "de novo basal body biogenesis" RELATED [] +synonym: "de novo basal body generation" RELATED [] +synonym: "de novo centriole amplification" RELATED [] +synonym: "de novo ciliary basal body assembly" RELATED [] +synonym: "multiciliation" RELATED [] +synonym: "multiciliogenesis" RELATED [] +is_a: GO:0098534 ! centriole assembly + +[Term] +id: GO:0097743 +name: de novo centriole assembly via blepharoplast +namespace: biological_process +def: "A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface." [GOC:cilia, PMID:25047614] +synonym: "multiciliation" RELATED [] +synonym: "multiciliogenesis" RELATED [] +is_a: GO:0097742 ! de novo centriole assembly + +[Term] +id: GO:0097744 +name: renal urate salt excretion +namespace: biological_process +def: "The elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine." [GOC:jl, PMID:25287933, PMID:3906799, Wikipedia:Renal_physiology#Secretion] +synonym: "urate excretion" BROAD [] +synonym: "urate salt excretion" BROAD [] +is_a: GO:0097254 ! renal tubular secretion + +[Term] +id: GO:0097745 +name: mitochondrial tRNA 5'-end processing +namespace: biological_process +def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:pf, PMID:21307182, PMID:26143376, PMID:27484477] +is_a: GO:0000964 ! mitochondrial RNA 5'-end processing +is_a: GO:0090646 ! mitochondrial tRNA processing +is_a: GO:0099116 ! tRNA 5'-end processing + +[Term] +id: GO:0097746 +name: blood vessel diameter maintenance +namespace: biological_process +alt_id: GO:0042312 +alt_id: GO:0050880 +def: "Any process that modulates the diameter of blood vessels." [GOC:pr] +synonym: "blood vessel diameter homeostasis" EXACT [] +synonym: "regulation of blood vessel diameter" EXACT [] +synonym: "regulation of blood vessel size" RELATED [] +synonym: "regulation of vasodilatation" RELATED [] +synonym: "regulation of vasodilation" RELATED [] +is_a: GO:0003018 ! vascular process in circulatory system +is_a: GO:0035296 ! regulation of tube diameter +relationship: part_of GO:0008015 ! blood circulation + +[Term] +id: GO:0097747 +name: RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [GOC:pf] +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0097748 +name: 3'-5' RNA polymerase activity +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end." [GOC:pf, PMID:22456265, PMID:27484477] +xref: RHEA:57528 +is_a: GO:0097747 ! RNA polymerase activity + +[Term] +id: GO:0097749 +name: membrane tubulation +namespace: biological_process +def: "A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules)." [GOC:pr] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0097750 +name: endosome membrane tubulation +namespace: biological_process +def: "A membrane tubulation process occurring in an endosome membrane." [GOC:bc, GOC:PARL, PMID:26911690] +synonym: "endosomal membrane tubulation" EXACT [] +is_a: GO:0007032 ! endosome organization +is_a: GO:0097749 ! membrane tubulation + +[Term] +id: GO:0097751 +name: spore-bearing structure formation +namespace: biological_process +def: "The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores." [GOC:di] +synonym: "sporangium formation" BROAD [] +synonym: "sporophore formation" EXACT [] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0075259 ! spore-bearing structure development + +[Term] +id: GO:0097752 +name: regulation of DNA stability +namespace: biological_process +def: "Any process that modulates the stability of DNA." [GOC:pr] +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0097753 +name: membrane bending +namespace: biological_process +def: "A membrane organization process resulting in the bending of a membrane." [GOC:krc, GOC:pr, GOC:vw, Wikipedia:Membrane_curvature] +synonym: "membrane curvature" RELATED [] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0097754 +name: clathrin-mediated membrane bending +namespace: biological_process +def: "A membrane bending process mediated by clathrin." [GOC:pr, Wikipedia:Membrane_curvature] +is_a: GO:0097753 ! membrane bending + +[Term] +id: GO:0097755 +name: obsolete positive regulation of blood vessel diameter +namespace: biological_process +def: "OBSOLETE. Any process that increases the diameter of blood vessels." [GOC:pr] +comment: This term was obsoleted because it corresponded to an existing term, GO:0042311 ; vasodilation. +synonym: "positive regulation of vasodilation" RELATED [] +is_obsolete: true + +[Term] +id: GO:0097756 +name: obsolete negative regulation of blood vessel diameter +namespace: biological_process +def: "OBSOLETE. Any process that decreases the diameter of blood vessels." [GOC:pr] +comment: This term was obsoleted because it corresponded to an existing term, GO:0042310 ; vasocontriction. +synonym: "negative regulation of vasodilation" RELATED [] +is_obsolete: true + +[Term] +id: GO:0098001 +name: receptor-mediated bacteriophage reversible attachment to host cell +namespace: biological_process +def: "Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection." [GOC:bm] +comment: This process was historically defined by the release, by Waring blending or sonication, by dilution and centrifugation, or by filtration and washing, of infective virions from their complexes with cells, thus contrary to what is observed after irreversible adsorption. +synonym: "phage reversible adsorption" RELATED [GOC:bm] +synonym: "reversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] +is_a: GO:0098671 ! adhesion receptor-mediated virion attachment to host cell + +[Term] +id: GO:0098002 +name: receptor-mediated bacteriophage irreversible attachment to host cell +namespace: biological_process +def: "The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell." [GOC:bm] +synonym: "irreversible bacteriophage attachment, binding of host cell surface receptor" EXACT [GOC:bf, GOC:jl] +synonym: "phage irreversible adsorption" RELATED [GOC:bm] +is_a: GO:0098670 ! entry receptor-mediated virion attachment to host cell + +[Term] +id: GO:0098003 +name: viral tail assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail." [GOC:bm] +synonym: "bacteriophage tail assembly" NARROW [GOC:bm] +synonym: "virus tail assembly" EXACT [GOC:bf, GOC:jl] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0098004 +name: virus tail fiber assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber." [GOC:bm] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0098003 ! viral tail assembly + +[Term] +id: GO:0098005 +name: viral head-tail joining +namespace: biological_process +def: "Process by which virus heads and tails are attached to each other." [GOC:bm] +synonym: "phage head tail joining" NARROW [GOC:bm] +synonym: "virus head-tail joining" EXACT [GOC:bf, GOC:jl] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019068 ! virion assembly + +[Term] +id: GO:0098006 +name: viral DNA genome packaging, headful +namespace: biological_process +def: "The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full." [GOC:bm] +comment: Generalized transducing phages usually use this mode of DNA packaging. +synonym: "phage headful packaging" NARROW [GOC:bm] +is_a: GO:0019073 ! viral DNA genome packaging + +[Term] +id: GO:0098009 +name: viral terminase, large subunit +namespace: cellular_component +def: "The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit." [GOC:bm, GOC:ch, GOC:jh2, PMID:18687036] +comment: This term should only be used when the large subunit consists of more than one polypeptide. +synonym: "virus terminase, large subunit" EXACT [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0043493 ! viral terminase complex + +[Term] +id: GO:0098015 +name: virus tail +namespace: cellular_component +def: "Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell." [GOC:bm] +comment: Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell. +synonym: "bacteriophage tail" NARROW [GOC:bm] +synonym: "viral tail" RELATED [GOC:bf] +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0098017 +name: viral capsid, major subunit +namespace: cellular_component +def: "The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits." [GOC:bm] +synonym: "major capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl] +synonym: "major head protein" RELATED [] +is_a: GO:0046727 ! capsomere + +[Term] +id: GO:0098018 +name: viral capsid, minor subunit +namespace: cellular_component +def: "The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits." [GOC:bm] +synonym: "minor capsomere" EXACT [GOC:bf, GOC:bm, GOC:jl] +synonym: "minor head protein" RELATED [] +is_a: GO:0046727 ! capsomere + +[Term] +id: GO:0098019 +name: obsolete virus tail, major subunit +namespace: cellular_component +def: "OBSOLETE. The part of the viral tail that comprises the most common subunit type." [GOC:bm] +comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages. +synonym: "major tail protein" RELATED [] +is_obsolete: true + +[Term] +id: GO:0098020 +name: obsolete virus tail, minor subunit +namespace: cellular_component +def: "OBSOLETE. The part of the viral tail that comprises the least common subunit type." [GOC:bm] +comment: The reason for obsoletion is that these are not precise structures: major (most abundant) and minor subunits of viral tails vary in different viruses/phages. +synonym: "bacteriophage minor protein subunit" NARROW [GOC:bm] +synonym: "minor tail protein" RELATED [GOC:bm] +is_obsolete: true + +[Term] +id: GO:0098021 +name: viral capsid, decoration +namespace: cellular_component +def: "Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential." [GOC:bm] +synonym: "decoration protein" RELATED [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019028 ! viral capsid + +[Term] +id: GO:0098022 +name: viral capsid, fiber +namespace: cellular_component +def: "A type of capsid decoration composed of fiber structures." [GOC:bm] +synonym: "head/capsid fiber" RELATED [GOC:bm] +is_a: GO:0098021 ! viral capsid, decoration + +[Term] +id: GO:0098023 +name: virus tail, tip +namespace: cellular_component +def: "The basal end of the virus tail, which is used by the virus to attach to the host cell." [GOC:bm] +synonym: "bacteriophage tail tip" NARROW [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098024 +name: virus tail, fiber +namespace: cellular_component +def: "The fibrous region of the virus tail used to scan, recognize and attach to the host cell." [GOC:bm] +comment: For tailed bacteriophages, fibers typically bind to particular Lipopolysaccharide (LPS), polysaccharide or protein receptors on the cell surface. +synonym: "bacteriophage tail fiber" NARROW [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098025 +name: virus tail, baseplate +namespace: cellular_component +def: "Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached." [GOC:bm] +comment: Tail fibers are often attached to the baseplate of Caudovirales (tailed bacteriophages with dsDNA genomes). Sometimes referred to as the tail tip or tip structure in Siphoviridae. +synonym: "bacteriophage baseplate" NARROW [GOC:bm] +synonym: "tail structure" RELATED [GOC:bm] +synonym: "tail tip" RELATED [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098026 +name: virus tail, tube +namespace: cellular_component +def: "The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm." [GOC:bm] +comment: Applies in particular the Myoviridae bacteriophages. +synonym: "bacteriophage tail tube" NARROW [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098027 +name: virus tail, sheath +namespace: cellular_component +def: "The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm." [GOC:bm] +synonym: "bacteriophage tail sheath" NARROW [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098028 +name: virus tail, shaft +namespace: cellular_component +def: "The tube of the non-contractile tails of some viruses." [GOC:bm] +comment: This term applies in particular to the Siphoviridae bacteriophages, where the shaft is the channel for DNA translocation into the host cytoplasm. +synonym: "bacteriophage tail shaft" NARROW [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0098015 ! virus tail + +[Term] +id: GO:0098029 +name: icosahedral viral capsid, spike +namespace: cellular_component +def: "A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell." [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0098030 +name: icosahedral viral capsid, neck +namespace: cellular_component +def: "A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae)." [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0098031 +name: icosahedral viral capsid, collar +namespace: cellular_component +def: "A small disk located at the base of some icosahedral virus capsids." [GOC:bm] +is_a: GO:0044423 ! virion component +relationship: part_of GO:0019030 ! icosahedral viral capsid + +[Term] +id: GO:0098032 +name: icosahedral viral capsid, collar fiber +namespace: cellular_component +def: "A fiber attached to the collar structure of some icosahedral viral capsids." [GOC:bm] +is_a: GO:0098022 ! viral capsid, fiber +relationship: part_of GO:0098031 ! icosahedral viral capsid, collar + +[Term] +id: GO:0098033 +name: icosahedral viral capsid, neck fiber +namespace: cellular_component +def: "A fiber attached to the neck at the base of some icosahedral viral capsids." [GOC:bm] +is_a: GO:0098022 ! viral capsid, fiber +relationship: part_of GO:0098030 ! icosahedral viral capsid, neck + +[Term] +id: GO:0098035 +name: viral DNA genome packaging via site-specific sequence recognition +namespace: biological_process +def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase." [GOC:bm] +is_a: GO:0019073 ! viral DNA genome packaging + +[Term] +id: GO:0098036 +name: viral DNA genome packaging, 3' extended cos packaging +namespace: biological_process +def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends." [GOC:bm] +is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition + +[Term] +id: GO:0098037 +name: viral DNA genome packaging, 5' extended cos packaging +namespace: biological_process +def: "The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends." [GOC:bm] +is_a: GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition + +[Term] +id: GO:0098038 +name: non-replicative transposition, DNA-mediated +namespace: biological_process +def: "Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition." [GOC:bm, PMID:2553270] +synonym: "cut-and-paste transposition" EXACT [GOC:bm] +is_a: GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0098039 +name: replicative transposition, DNA-mediated +namespace: biological_process +def: "Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition." [GOC:bm, PMID:10540284] +synonym: "copy-and-paste transposition" EXACT [GOC:bm] +synonym: "transpositional DNA genome replication" EXACT [] +is_a: GO:0006313 ! transposition, DNA-mediated + +[Term] +id: GO:0098045 +name: virus baseplate assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a virus baseplate." [GOC:bm] +is_a: GO:0016032 ! viral process +relationship: part_of GO:0098003 ! viral tail assembly + +[Term] +id: GO:0098046 +name: type V protein secretion system complex +namespace: cellular_component +def: "A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc)." [GOC:bf, GOC:bhm, PMID:15119822, PMID:15590781] +comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. +synonym: "autotransporter system complex" NARROW [PMID:15590781, Wikipedia:Secretion] +synonym: "T5SS complex" EXACT [Wikipedia:Secretion] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098061 +name: viral capsid, internal space +namespace: cellular_component +def: "The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins." [GOC:bm] +synonym: "internal head protein" EXACT [GOC:bm] +is_a: GO:0044423 ! virion component + +[Term] +id: GO:0098501 +name: obsolete polynucleotide dephosphorylation +namespace: biological_process +def: "OBSOLETE. The process of removing one or more phosphate groups from a polynucleotide." [GOC:DOS] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0098502 +name: obsolete DNA dephosphorylation +namespace: biological_process +def: "OBSOLETE. The process of removing one or more phosphate groups from a DNA molecule." [GOC:DOS] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0098503 +name: obsolete DNA 3' dephosphorylation +namespace: biological_process +def: "OBSOLETE. The process of removing a 3' phosphate group from a DNA molecule." [GOC:DOS] +comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process. +is_obsolete: true + +[Term] +id: GO:0098504 +name: obsolete DNA 3' dephosphorylation involved in DNA repair +namespace: biological_process +def: "OBSOLETE. Any 3' DNA dephosphorylation that is involved in the process of DNA repair." [GOC:DOS, PMID:11729194] +comment: This term was obsoleted because it represents a molecular function, and not a specific coordinated process. +is_obsolete: true + +[Term] +id: GO:0098505 +name: G-rich strand telomeric DNA binding +namespace: molecular_function +def: "Binding to G-rich, single-stranded, telomere-associated DNA." [PMID:11349150] +is_a: GO:0043047 ! single-stranded telomeric DNA binding + +[Term] +id: GO:0098506 +name: polynucleotide 3' dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate groups from the 3' end of a polynucleotide." [GOC:dos] +is_a: GO:0016311 ! dephosphorylation + +[Term] +id: GO:0098507 +name: polynucleotide 5' dephosphorylation +namespace: biological_process +def: "The process of removing one or more phosphate groups from the 5' end of a polynucleotide." [GOC:dos] +is_a: GO:0016311 ! dephosphorylation + +[Term] +id: GO:0098508 +name: endothelial to hematopoietic transition +namespace: biological_process +def: "The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium." [PMID:20154732, PMID:22521721] +is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0060232 ! delamination + +[Term] +id: GO:0098509 +name: sensory perception of humidity +namespace: biological_process +def: "The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908, PMID:8650222] +comment: Note, this is not classified under 'detection of chemical stimulus' as there are various potential mechanisms of hygroperception including detection of mechanical stimulus. +synonym: "hygrosensory perception" EXACT [PMID:8650222] +is_a: GO:0007600 ! sensory perception + +[Term] +id: GO:0098510 +name: sensory perception of high humidity +namespace: biological_process +def: "The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908] +is_a: GO:0098509 ! sensory perception of humidity + +[Term] +id: GO:0098511 +name: sensory perception of low humidity +namespace: biological_process +def: "The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process." [PMID:18269908] +is_a: GO:0098509 ! sensory perception of humidity + +[Term] +id: GO:0098512 +name: detection of humidity stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity." [GOC:dos, PMID:8650222] +is_a: GO:0050906 ! detection of stimulus involved in sensory perception +is_a: GO:0098513 ! detection of humidity +relationship: part_of GO:0098509 ! sensory perception of humidity + +[Term] +id: GO:0098513 +name: detection of humidity +namespace: biological_process +def: "The series of events in which a humidity stimulus is received and converted into a molecular signal." [GOC:dos] +is_a: GO:0009581 ! detection of external stimulus +is_a: GO:0009582 ! detection of abiotic stimulus + +[Term] +id: GO:0098514 +name: detection of high humidity stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity." [GOC:dos, PMID:18269908] +is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception +is_a: GO:0098516 ! detection of high humidity +relationship: part_of GO:0098510 ! sensory perception of high humidity + +[Term] +id: GO:0098515 +name: detection of low humidity stimulus involved in sensory perception +namespace: biological_process +def: "The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity." [GOC:dos, PMID:18269908] +is_a: GO:0098512 ! detection of humidity stimulus involved in sensory perception +is_a: GO:0098517 ! detection of low humidity +relationship: part_of GO:0098511 ! sensory perception of low humidity + +[Term] +id: GO:0098516 +name: detection of high humidity +namespace: biological_process +def: "The series of events in which high humidity is detected and converted into a molecular signal." [GOC:dos] +is_a: GO:0098513 ! detection of humidity + +[Term] +id: GO:0098517 +name: detection of low humidity +namespace: biological_process +def: "The series of events in which low humidity is detected and converted into a molecular signal." [GOC:dos] +is_a: GO:0098513 ! detection of humidity + +[Term] +id: GO:0098518 +name: polynucleotide phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0098519 +name: nucleotide phosphatase activity, acting on free nucleotides +namespace: molecular_function +def: "Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate." [GOC:dos] +comment: To be used for NTP->NDP or NDP -> NMP. For nucleotide -> nucleoside (all phosphates removed) use nucleotidase. +synonym: "nucleotide phosphatase activity" EXACT [] +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0098520 +name: excitatory neuromuscular junction +namespace: cellular_component +def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction." [GOC:dos] +is_a: GO:0031594 ! neuromuscular junction +is_a: GO:0060076 ! excitatory synapse + +[Term] +id: GO:0098521 +name: inhibitory neuromuscular junction +namespace: cellular_component +def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction." [GOC:dos] +comment: Inhibitory neuromuscular junctions are found in arthropods but not in vertebrates. +is_a: GO:0031594 ! neuromuscular junction +is_a: GO:0060077 ! inhibitory synapse + +[Term] +id: GO:0098522 +name: neuromuscular junction of skeletal muscle fiber +namespace: cellular_component +def: "A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber." [GOC:dos] +comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. +is_a: GO:0098520 ! excitatory neuromuscular junction +is_a: GO:0098523 ! neuromuscular junction of myotube +is_a: GO:0098981 ! cholinergic synapse + +[Term] +id: GO:0098523 +name: neuromuscular junction of myotube +namespace: cellular_component +def: "A neuromuscular junction in which the target muscle cell is a myotube." [GOC:dos] +comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting the myotubes of skeletal muscle (AKA skeletal muscle fibers). Neuromuscular junctions targeting other muscle cell types exist in invertebrates such as the mononucleate somatic muscles of nematodes. +is_a: GO:0031594 ! neuromuscular junction + +[Term] +id: GO:0098524 +name: neuromuscular junction of somatic muscle myotube +namespace: cellular_component +def: "A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell." [GOC:dos] +is_a: GO:0098523 ! neuromuscular junction of myotube +is_a: GO:0098527 ! neuromuscular junction of somatic muscle + +[Term] +id: GO:0098525 +name: excitatory neuromuscular junction of somatic myotube +namespace: cellular_component +def: "A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells." [GOC:dos] +is_a: GO:0098520 ! excitatory neuromuscular junction +is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube + +[Term] +id: GO:0098526 +name: inhibitory neuromuscular junction of somatic myotube +namespace: cellular_component +def: "A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods." [GOC:dos] +is_a: GO:0098521 ! inhibitory neuromuscular junction +is_a: GO:0098524 ! neuromuscular junction of somatic muscle myotube + +[Term] +id: GO:0098527 +name: neuromuscular junction of somatic muscle +namespace: cellular_component +def: "A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods." [GOC:dos] +is_a: GO:0031594 ! neuromuscular junction + +[Term] +id: GO:0098528 +name: skeletal muscle fiber differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract." [GOC:dos] +is_a: GO:0014902 ! myotube differentiation +is_a: GO:0035914 ! skeletal muscle cell differentiation + +[Term] +id: GO:0098529 +name: neuromuscular junction development, skeletal muscle fiber +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber." [GOC:mtg_OBO2OWL_2013] +is_a: GO:0007528 ! neuromuscular junction development +relationship: part_of GO:0048741 ! skeletal muscle fiber development + +[Term] +id: GO:0098530 +name: positive regulation of strand invasion +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:dos, GOC:dph, GOC:elh, GOC:tb] +synonym: "positive regulation of D-loop biosynthesis" RELATED [GOC:elh] +synonym: "positive regulation of D-loop formation" RELATED [GOC:elh] +synonym: "positive regulation of Rad51-mediated strand invasion" EXACT [GOC:elh] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0060542 ! regulation of strand invasion +relationship: positively_regulates GO:0042148 ! strand invasion + +[Term] +id: GO:0098531 +name: ligand-activated transcription factor activity +namespace: molecular_function +def: "A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors." [GOC:dos, PMID:25568920, PMID:8735275] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +synonym: "direct ligand regulated sequence-specific DNA binding transcription factor activity" EXACT [] +synonym: "transcription factor activity, direct ligand regulated sequence-specific DNA binding" EXACT [] +is_a: GO:0003700 ! DNA-binding transcription factor activity + +[Term] +id: GO:0098532 +name: histone H3-K27 trimethylation +namespace: biological_process +def: "The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone." [PMID:19270745] +is_a: GO:0070734 ! histone H3-K27 methylation + +[Term] +id: GO:0098533 +name: ATPase dependent transmembrane transport complex +namespace: cellular_component +def: "A transmembrane protein complex that functions in ATPase dependent active transport across a membrane." [GOC:dos] +comment: The location of this complex is implicit in its activity, so its location is asserted as a regular relationship rather than as a part of an intersection. +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:0098534 +name: centriole assembly +namespace: biological_process +def: "A cellular process that results in the assembly of one or more centrioles." [GOC:dos, PMID:24075808] +is_a: GO:0031023 ! microtubule organizing center organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:0098535 +name: de novo centriole assembly involved in multi-ciliated epithelial cell differentiation +namespace: biological_process +def: "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation." [GOC:cilia, GOC:dos, PMID:24075808, PMID:5111878, PMID:5661997] +comment: In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. +synonym: "centriole amplification" RELATED [PMID:24075808] +synonym: "de novo centriole assembly" BROAD [] +synonym: "de novo centriole assembly via deuterosome" EXACT [] +synonym: "deuterosomal basal body biogenesis" RELATED [] +synonym: "deuterosome pathway" RELATED [PMID:25047614] +synonym: "deuterosome-mediated centriole biogenesis" RELATED [PMID:24075808] +synonym: "multiciliation" RELATED [] +synonym: "multiciliogenesis" RELATED [] +is_a: GO:0097742 ! de novo centriole assembly +relationship: part_of GO:1903251 ! multi-ciliated epithelial cell differentiation + +[Term] +id: GO:0098536 +name: deuterosome +namespace: cellular_component +def: "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles." [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0098537 +name: obsolete lobed nucleus +namespace: cellular_component +def: "OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm] +comment: This term was obsoleted because it does not correspond to a specific type of nucleus, it is a morphologically different nucleus present in certain cell types. +is_obsolete: true + +[Term] +id: GO:0098538 +name: lumenal side of transport vesicle membrane +namespace: cellular_component +def: "The side (leaflet) of the transport vesicle membrane that faces the lumen." [GOC:ab] +synonym: "internal side of transport vesicle membrane" EXACT [] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0030658 ! transport vesicle membrane + +[Term] +id: GO:0098539 +name: cytoplasmic side of transport vesicle membrane +namespace: cellular_component +def: "The side (leaflet) of the transport vesicle membrane that faces the cytoplasm." [GOC:ab] +synonym: "external side of transport vesicle membrane" EXACT [] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0030658 ! transport vesicle membrane + +[Term] +id: GO:0098540 +name: lumenal side of trans-Golgi network transport vesicle membrane +namespace: cellular_component +def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen." [GOC:ab] +synonym: "internal side of trans-Golgi network transport vesicle membrane" RELATED [] +is_a: GO:0098538 ! lumenal side of transport vesicle membrane +relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane + +[Term] +id: GO:0098541 +name: cytoplasmic side of trans-Golgi network transport vesicle membrane +namespace: cellular_component +def: "The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the cytoplasm." [GOC:ab] +synonym: "external side of trans-Golgi network transport vesicle membrane" EXACT [] +is_a: GO:0098539 ! cytoplasmic side of transport vesicle membrane +relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane + +[Term] +id: GO:0098542 +name: defense response to other organism +namespace: biological_process +alt_id: GO:0009814 +def: "Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism." [GOC:dos] +subset: goslim_generic +synonym: "defence response incompatible interaction" NARROW [] +synonym: "defence response to pathogen, incompatible interaction" NARROW [] +synonym: "defense response, incompatible interaction" NARROW [] +synonym: "resistance response to pathogen" NARROW [] +is_a: GO:0006952 ! defense response +is_a: GO:0051707 ! response to other organism + +[Term] +id: GO:0098543 +name: detection of other organism +namespace: biological_process +alt_id: GO:0051824 +def: "The series of events in which a stimulus from another organism is received and converted into a molecular signal." [GOC:dos] +synonym: "recognition of other organism during symbiotic interaction" NARROW [GOC:dph] +synonym: "recognition of other organism involved in symbiotic interaction" NARROW [] +is_a: GO:0051707 ! response to other organism +is_a: GO:0098581 ! detection of external biotic stimulus + +[Term] +id: GO:0098544 +name: maintenance of protein complex location +namespace: biological_process +def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051235 ! maintenance of location + +[Term] +id: GO:0098545 +name: maintenance of protein complex location in cytoplasm +namespace: biological_process +def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos] +is_a: GO:0051651 ! maintenance of location in cell +is_a: GO:0098544 ! maintenance of protein complex location + +[Term] +id: GO:0098547 +name: lumenal side of Golgi membrane +namespace: cellular_component +def: "The side of the Golgi membrane that faces the lumen." [GOC:ab, GOC:dos] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0000139 ! Golgi membrane + +[Term] +id: GO:0098548 +name: cytoplasmic side of Golgi membrane +namespace: cellular_component +def: "The side (leaflet) of the Golgi membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0000139 ! Golgi membrane + +[Term] +id: GO:0098549 +name: somatic ring canal +namespace: cellular_component +def: "A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects." [GOC:dos, PMID:22135360, PMID:670316] +is_a: GO:0045171 ! intercellular bridge + +[Term] +id: GO:0098550 +name: lumenal side of early endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the early endosome membrane that faces the lumen." [GOC:lr] +synonym: "internal leaflet of early endosome membrane" EXACT [GOC:ab] +synonym: "internal side of early endosome membrane" EXACT [] +is_a: GO:0098565 ! lumenal side of endosome membrane +relationship: part_of GO:0031901 ! early endosome membrane + +[Term] +id: GO:0098551 +name: lumenal side of late endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the late endosome membrane that faces the lumen." [GOC:lr] +synonym: "internal leaflet of late endosome membrane" EXACT [GOC:ab] +synonym: "internal side of late endosome membrane" EXACT [] +is_a: GO:0098565 ! lumenal side of endosome membrane +relationship: part_of GO:0031902 ! late endosome membrane + +[Term] +id: GO:0098552 +name: side of membrane +namespace: cellular_component +def: "A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface." [GOC:dos] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0098553 +name: lumenal side of endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the plasma membrane that faces the lumen." [GOC:ab, GOC:dos] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0098554 +name: cytoplasmic side of endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:0098555 +name: lumenal side of rough endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos] +is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0098556 +name: cytoplasmic side of rough endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane +relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane + +[Term] +id: GO:0098557 +name: cytoplasmic side of smooth endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +is_a: GO:0098554 ! cytoplasmic side of endoplasmic reticulum membrane +relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane + +[Term] +id: GO:0098558 +name: lumenal side of smooth endoplasmic reticulum membrane +namespace: cellular_component +def: "The side (leaflet) of the smooth endoplasmic reticulum membrane that faces the lumen." [GOC:ab, GOC:dos] +is_a: GO:0098553 ! lumenal side of endoplasmic reticulum membrane +relationship: part_of GO:0030868 ! smooth endoplasmic reticulum membrane + +[Term] +id: GO:0098559 +name: cytoplasmic side of early endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the early endosome membrane that faces the cytoplasm." [GOC:lr] +comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. +synonym: "external leaflet of early endosome membrane" EXACT [GOC:ab] +synonym: "external side of early endosome membrane" EXACT [] +is_a: GO:0010009 ! cytoplasmic side of endosome membrane +relationship: part_of GO:0031901 ! early endosome membrane + +[Term] +id: GO:0098560 +name: cytoplasmic side of late endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the late endosome membrane that faces the cytoplasm." [GOC:lr] +comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. +synonym: "external leaflet of late endosome membrane" EXACT [GOC:ab] +synonym: "external side of late endosome membrane" EXACT [] +is_a: GO:0010009 ! cytoplasmic side of endosome membrane +relationship: part_of GO:0031902 ! late endosome membrane + +[Term] +id: GO:0098561 +name: methyl accepting chemotaxis protein complex +namespace: cellular_component +def: "A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus." [GOC:dos, PMID:1326408, PMID:15802240] +comment: A number of complexes of this class are found in E.coli. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098562 +name: cytoplasmic side of membrane +namespace: cellular_component +def: "The side of a membrane that faces the cytoplasm." [GOC:dos] +is_a: GO:0098552 ! side of membrane + +[Term] +id: GO:0098563 +name: intrinsic component of synaptic vesicle membrane +namespace: cellular_component +def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0030672 ! synaptic vesicle membrane + +[Term] +id: GO:0098564 +name: trans-Golgi network transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed within the membrane of a trans-Golgi network transport vesicle." [GOC:dos] +is_a: GO:0005796 ! Golgi lumen +is_a: GO:0098566 ! transport vesicle lumen +relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle + +[Term] +id: GO:0098565 +name: lumenal side of endosome membrane +namespace: cellular_component +def: "The side (leaflet) of the endosome membrane that faces the lumen." [GOC:dos] +synonym: "internal leaflet of endosome membrane" EXACT [GOC:ab] +synonym: "internal side of endosome membrane" EXACT [] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0098566 +name: transport vesicle lumen +namespace: cellular_component +def: "The volume enclosed within the membrane of a transport vesicle." [GOC:dos] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0030133 ! transport vesicle + +[Term] +id: GO:0098567 +name: periplasmic side of plasma membrane +namespace: cellular_component +def: "The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface." [GOC:dos] +is_a: GO:0009897 ! external side of plasma membrane + +[Term] +id: GO:0098568 +name: external side of mycolate outer membrane +namespace: cellular_component +def: "The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface." [GOC:dos, PMID:18316738, PMID:18567661] +is_a: GO:0031240 ! external side of cell outer membrane + +[Term] +id: GO:0098569 +name: internal side of mycolate outer membrane +namespace: cellular_component +def: "The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network." [GOC:dos, PMID:18316738, PMID:18567661] +is_a: GO:0098552 ! side of membrane + +[Term] +id: GO:0098570 +name: stromal side of plastid inner membrane +namespace: cellular_component +def: "The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0009528 ! plastid inner membrane + +[Term] +id: GO:0098571 +name: lumenal side of plastid thylakoid membrane +namespace: cellular_component +def: "The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0055035 ! plastid thylakoid membrane + +[Term] +id: GO:0098572 +name: stromal side of plastid thylakoid membrane +namespace: cellular_component +def: "The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface." [GOC:dos] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0055035 ! plastid thylakoid membrane + +[Term] +id: GO:0098573 +name: intrinsic component of mitochondrial membrane +namespace: cellular_component +def: "The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] +synonym: "intrinsic to mitochondrial membrane" NARROW [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0031966 ! mitochondrial membrane + +[Term] +id: GO:0098574 +name: cytoplasmic side of lysosomal membrane +namespace: cellular_component +def: "The side (leaflet) of the lysosomal membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +synonym: "external leaflet of lysosomal membrane" EXACT [GOC:dos] +synonym: "external side of lysosomal membrane" EXACT [] +is_a: GO:0098562 ! cytoplasmic side of membrane +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0098575 +name: lumenal side of lysosomal membrane +namespace: cellular_component +def: "The side (leaflet) of the lysosomal membrane that faces the lumen." [GOC:dos] +synonym: "internal leaflet of lysosomal membrane" EXACT [GOC:ab] +synonym: "internal side of lysosomal membrane" EXACT [] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:0098576 +name: lumenal side of membrane +namespace: cellular_component +def: "Any side (leaflet) of a membrane that faces the lumen of an organelle." [GOC:dos] +is_a: GO:0098552 ! side of membrane +relationship: part_of GO:0031090 ! organelle membrane + +[Term] +id: GO:0098577 +name: inactive sex chromosome +namespace: cellular_component +def: "A sex chromosome that has been inactivated." [GOC:dos] +synonym: "inactivated sex chromosome" EXACT [] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0098578 +name: condensed chromatin of inactivated sex chromosome +namespace: cellular_component +def: "A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation." [GOC:dos] +is_a: GO:0001739 ! sex chromatin +relationship: part_of GO:0098577 ! inactive sex chromosome + +[Term] +id: GO:0098579 +name: active sex chromosome +namespace: cellular_component +def: "A sex chromosome that has not been inactivated." [GOC:dos] +is_a: GO:0000803 ! sex chromosome + +[Term] +id: GO:0098580 +name: obsolete chromatin of active sex chromosome +namespace: cellular_component +def: "OBSOLETE. Chromatin that is part of an active sex chromosome." [GOC:dos, PMID:23816838] +comment: This term was obsoleted because it represents a biological process, not a cellular localization. +is_obsolete: true + +[Term] +id: GO:0098581 +name: detection of external biotic stimulus +namespace: biological_process +def: "The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated." [GOC:dos] +synonym: "detection of exogenous biotic stimulus" EXACT [] +is_a: GO:0009595 ! detection of biotic stimulus +is_a: GO:0043207 ! response to external biotic stimulus + +[Term] +id: GO:0098582 +name: innate vocalization behavior +namespace: biological_process +def: "A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur." [GOC:BHF, GOC:dos, GOC:rl] +is_a: GO:0071625 ! vocalization behavior + +[Term] +id: GO:0098583 +name: learned vocalization behavior +namespace: biological_process +def: "A vocalization behavior that is the result of learning." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] +comment: Examples include human speech and learned bird song. +is_a: GO:0071625 ! vocalization behavior +is_a: GO:0098598 ! learned vocalization behavior or vocal learning + +[Term] +id: GO:0098584 +name: host cell synaptic vesicle +namespace: cellular_component +def: "A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [GOC:dos] +is_a: GO:0044161 ! host cell cytoplasmic vesicle +relationship: part_of GO:0044221 ! host cell synapse + +[Term] +id: GO:0098585 +name: host cell synaptic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a host synaptic vesicle." [GOC:dos] +is_a: GO:0044162 ! host cell cytoplasmic vesicle membrane +relationship: part_of GO:0098584 ! host cell synaptic vesicle + +[Term] +id: GO:0098586 +name: cellular response to virus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:dos] +is_a: GO:0009615 ! response to virus + +[Term] +id: GO:0098588 +name: bounding membrane of organelle +namespace: cellular_component +def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] +comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. +is_a: GO:0031090 ! organelle membrane + +[Term] +id: GO:0098590 +name: plasma membrane region +namespace: cellular_component +def: "A membrane that is a (regional) part of the plasma membrane." [GOC:dos] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. +subset: gocheck_do_not_manually_annotate +synonym: "region of plasma membrane" EXACT [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0098591 +name: external side of apical plasma membrane +namespace: cellular_component +def: "The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:ab, GOC:dos] +is_a: GO:0009897 ! external side of plasma membrane +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0098592 +name: cytoplasmic side of apical plasma membrane +namespace: cellular_component +def: "The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm." [GOC:ab, GOC:dos] +is_a: GO:0009898 ! cytoplasmic side of plasma membrane +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0098593 +name: goblet cell theca +namespace: cellular_component +def: "A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel." [PMID:6541604] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0098594 +name: mucin granule +namespace: cellular_component +def: "A secretory granule that contains mucin." [PMID:16377632] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0098595 +name: perivitelline space +namespace: cellular_component +def: "The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane)." [GOC:dos] +is_a: GO:0005576 ! extracellular region + +[Term] +id: GO:0098596 +name: imitative learning +namespace: biological_process +def: "Learning in which new behaviors are acquired through imitation." [GOC:dos, Wikipedia:Imitative_learning&oldid=593192364] +xref: Wikipedia:Imitative_learning +xref: Wikipedia:Observational_learning#Observational_learning_compared_to_imitation +is_a: GO:0098597 ! observational learning + +[Term] +id: GO:0098597 +name: observational learning +namespace: biological_process +def: "Learning that occurs through observing the behavior of others." [GOC:dos, Wikipedia:Observational_learning&oldid=603524137] +comment: Observation here is used in a broad sense to include perception of the behavior of others via any form or combination of forms of sensory perception (visual, auditory etc). Observational learning is broader than imitative learning in that it does not require a duplication of the behavior exhibited by the model. +xref: Wikipedia:Observational_learning +is_a: GO:0007612 ! learning + +[Term] +id: GO:0098598 +name: learned vocalization behavior or vocal learning +namespace: biological_process +def: "Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521] +comment: This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior. +is_a: GO:0007611 ! learning or memory + +[Term] +id: GO:0098599 +name: palmitoyl hydrolase activity +namespace: molecular_function +def: "Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate." [GOC:dos, GOC:pg] +xref: Reactome:R-HSA-5690046 "PPT2 hydrolyses PALMCoA to PALM" +xref: Reactome:R-HSA-9027670 "ESTG binding induces ESR depalmitoylation" +is_a: GO:0016787 ! hydrolase activity + +[Term] +id: GO:0098600 +name: selenomethionine gamma-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid." [PMID:11578145, PMID:16037612, PMID:16444005] +xref: Reactome:R-HSA-2408537 "Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH" +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0098601 +name: selenomethionine adenosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine." [PMID:2339986] +xref: Reactome:R-HSA-2408551 "SeMet is converted to AdoSeMet by MAT" +xref: RHEA:31211 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0098603 +name: selenol Se-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine." [PMID:1711890] +xref: Reactome:R-HSA-2408544 "AdoSeMet is converted to AdeSeHCys by MetTrans(1)" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0098604 +name: adenosylselenohomocysteinase activity +namespace: molecular_function +def: "Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine." [GOC:dos, PMID:1711890, PMID:7305945] +xref: Reactome:R-HSA-2408532 "AdeSeHCys is hydrolysed to SeHCys by AHCY" +is_a: GO:0016802 ! trialkylsulfonium hydrolase activity + +[Term] +id: GO:0098605 +name: selenocystathionine beta-synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O." [PMID:6456763] +xref: Reactome:R-HSA-2408559 "SeHCys and Ser are dehydrated into SeCysta by CBS" +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0098606 +name: selenocystathionine gamma-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid." [PMID:6456763] +xref: Reactome:R-HSA-2408543 "SeCysta is hydrolysed to Sec by PXLP-K212-CTH" +xref: RHEA:31151 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0098607 +name: methylselenocysteine deselenhydrase activity +namespace: molecular_function +def: "Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol." [PMID:17451884, PMID:20383543] +xref: Reactome:R-HSA-2408539 "MeSec is hydrolysed to MeSeH by PXLP-K212-CTH" +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:0098608 +name: methylselenol demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH." [PMID:17451884, PMID:17988700] +xref: Reactome:R-HSA-2408530 "MeSeH is hydrolysed to H2Se by methylselenol demethylase" +is_a: GO:0032451 ! demethylase activity + +[Term] +id: GO:0098609 +name: cell-cell adhesion +namespace: biological_process +alt_id: GO:0016337 +def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] +synonym: "single organismal cell-cell adhesion" RELATED [] +is_a: GO:0007155 ! cell adhesion + +[Term] +id: GO:0098610 +name: adhesion between unicellular organisms +namespace: biological_process +alt_id: GO:0098741 +def: "The attachment of two unicellular organisms to each other." [GOC:dos] +synonym: "adhesion between unicellular organisms via cell-wall interaction" NARROW [] +synonym: "multi-organismal cell-cell adhesion" BROAD [] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0098613 +name: methaneselenol methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide." [PMID:14705, PMID:17988700, PMID:4380351] +xref: Reactome:R-HSA-2408541 "MeSeH is methylated to Me2Se by MeSeH methyltransferase" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0098614 +name: hydrogen selenide methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol." [PMID:14705, PMID:17988700] +xref: Reactome:R-HSA-2408536 "H2Se is methylated to MeSeH by H2Se methyltransferase" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0098615 +name: dimethyl selenide methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium." [PMID:17988700, PMID:3350800] +xref: Reactome:R-HSA-2408554 "Me2Se is methylated to Me3Se+ by INMT" +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0098616 +name: selenate adenylyltransferase (ATP) activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate." [PMID:2537056] +xref: Reactome:R-HSA-2408525 "H2SeO4 is converted to APSe by PAPSS1,2" +is_a: GO:0070566 ! adenylyltransferase activity + +[Term] +id: GO:0098617 +name: adenylylselenate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate." [PMID:2537056] +xref: Reactome:R-HSA-2408540 "APSe is phosphorylated to PAPSe by PAPSS1,2" +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0098618 +name: selenomethionine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met)." [PMID:16661668, PMID:16661782] +xref: Reactome:R-HSA-2408546 "tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex" +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0098619 +name: selenocysteine-tRNA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate." [PMID:8890909, PMID:9431993, PMID:9637248] +xref: Reactome:R-HSA-2408526 "tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer" +is_a: GO:0004812 ! aminoacyl-tRNA ligase activity + +[Term] +id: GO:0098620 +name: seryl-selenocysteinyl-tRNA kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP." [PMID:15317934] +xref: Reactome:R-HSA-2408507 "Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK" +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0098621 +name: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid." [PMID:17142313, PMID:19608919, RHEA:25041] +xref: EC:2.9.1.2 +xref: Reactome:R-HSA-2408555 "Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer" +xref: RHEA:25041 +is_a: GO:0016785 ! selenotransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0098622 +name: selenodiglutathione-disulfide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+." [PMID:1569062] +xref: Reactome:R-HSA-2408542 "GSSeSG is reduced to GSSeH and GSH by GSR" +xref: RHEA:34927 +is_a: GO:0015036 ! disulfide oxidoreductase activity +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0098623 +name: selenite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O." [PMID:1321713] +xref: Reactome:R-HSA-2408558 "SeO3(2-) is reduced to H2Se by TXNRD1" +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0098624 +name: 3'-phosphoadenylylselenate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+." [PMID:14723223] +synonym: "PAPSe reductase activity" EXACT [PMID:14723223] +xref: Reactome:R-HSA-2408548 "PAPSe is reduced to SeO3(2-) by PAPSe reductase" +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0098625 +name: methylselenol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O." [PMID:11782468] +xref: Reactome:R-HSA-5263614 "MeSeOH is reduced to MeSeH by TXNRD1" +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0098626 +name: methylseleninic acid reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O." [PMID:11782468] +xref: Reactome:R-HSA-5263616 "MeSeO2H is reduced to MeSeOH by TXNRD1" +is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H + +[Term] +id: GO:0098627 +name: protein arginine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate." [PMID:23770242, RHEA:43380] +comment: Made part of peptidyl-N-phospho-arginine phosphatase activity on the assumption that arginine phosphorylation in proteins occurs via an N link. +xref: EC:3.9.1.2 +xref: RHEA:43380 +is_a: GO:0004721 ! phosphoprotein phosphatase activity +is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds + +[Term] +id: GO:0098628 +name: peptidyl-N-phospho-arginine dephosphorylation +namespace: biological_process +def: "The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine." [PMID:23770242] +is_a: GO:0006470 ! protein dephosphorylation + +[Term] +id: GO:0098629 +name: trans-Golgi network membrane organization +namespace: biological_process +def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane." [GOC:di, GOC:dos, PMID:23345439] +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0098630 +name: aggregation of unicellular organisms +namespace: biological_process +def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos] +synonym: "aggregation of single cell organisms" EXACT [] +is_a: GO:0098743 ! cell aggregation + +[Term] +id: GO:0098631 +name: cell adhesion mediator activity +namespace: molecular_function +def: "The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell." [GOC:vw, Wikipedia:Cell_adhesion] +subset: goslim_generic +synonym: "cell adhesion molecule" EXACT [] +synonym: "protein binding involved in cell adhesion" EXACT [] +is_a: GO:0050839 ! cell adhesion molecule binding + +[Term] +id: GO:0098632 +name: cell-cell adhesion mediator activity +namespace: molecular_function +def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell." [Wikipedia:Cell_adhesion] +synonym: "cell-cell adhesion molecule" EXACT [] +synonym: "protein binding involved in cell-cell adhesion" EXACT [] +is_a: GO:0098631 ! cell adhesion mediator activity + +[Term] +id: GO:0098633 +name: collagen fibril binding +namespace: molecular_function +def: "Binding to a collagen fibril." [GOC:dos, PMID:21421911] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0098634 +name: cell-matrix adhesion mediator activity +namespace: molecular_function +def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix." [Wikipedia:Cell_adhesion] +synonym: "cell-matrix adhesion molecule" EXACT [] +synonym: "protein binding involved in cell-matrix adhesion" EXACT [] +is_a: GO:0098631 ! cell adhesion mediator activity + +[Term] +id: GO:0098635 +name: protein complex involved in cell-cell adhesion +namespace: cellular_component +def: "Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion." [GOC:dos] +is_a: GO:0098636 ! protein complex involved in cell adhesion + +[Term] +id: GO:0098636 +name: protein complex involved in cell adhesion +namespace: cellular_component +alt_id: GO:1990307 +def: "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell." [GOC:dos] +synonym: "cell adhesion complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098637 +name: protein complex involved in cell-matrix adhesion +namespace: cellular_component +def: "Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion." [GOC:dos] +is_a: GO:0098636 ! protein complex involved in cell adhesion + +[Term] +id: GO:0098638 +name: laminin binding involved in cell-matrix adhesion +namespace: molecular_function +def: "Any laminin protein binding that occurs as part of cell-matrix adhesion." [GOC:dos] +is_a: GO:0043236 ! laminin binding +is_a: GO:0098634 ! cell-matrix adhesion mediator activity + +[Term] +id: GO:0098639 +name: collagen binding involved in cell-matrix adhesion +namespace: molecular_function +def: "Any collagen binding that occurs as part of cell-matrix adhesion." [GOC:dos] +is_a: GO:0005518 ! collagen binding +is_a: GO:0098634 ! cell-matrix adhesion mediator activity + +[Term] +id: GO:0098640 +name: integrin binding involved in cell-matrix adhesion +namespace: molecular_function +def: "Any integrin binding that occurs as part of the process of cell-matrix adhesion." [GOC:dos] +is_a: GO:0005178 ! integrin binding +is_a: GO:0098634 ! cell-matrix adhesion mediator activity + +[Term] +id: GO:0098641 +name: cadherin binding involved in cell-cell adhesion +namespace: molecular_function +def: "Any cadherin binding that occurs as part of the process of cell-cell adhesion." [GOC:dos] +is_a: GO:0045296 ! cadherin binding +is_a: GO:0098632 ! cell-cell adhesion mediator activity + +[Term] +id: GO:0098642 +name: network-forming collagen trimer +namespace: cellular_component +def: "A collagen trimer that forms networks." [PMID:21421911] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0098645 ! collagen network + +[Term] +id: GO:0098643 +name: banded collagen fibril +namespace: cellular_component +def: "A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands)." [GOC:dos, PMID:21421911] +is_a: GO:0098644 ! complex of collagen trimers +is_a: GO:0099512 ! supramolecular fiber + +[Term] +id: GO:0098644 +name: complex of collagen trimers +namespace: cellular_component +def: "A complex of collagen trimers such as a fibril or collagen network." [GOC:dos] +synonym: "Supramolecular aggregate of collagen" EXACT [PMID:19693541] +synonym: "Supramolecular collagen assembly" EXACT [PMID:21421911] +is_a: GO:0099080 ! supramolecular complex +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0098645 +name: collagen network +namespace: cellular_component +def: "A supramolecular complex that consists of collagen triple helices associated to form a network." [GOC:dos, PMID:21421911] +is_a: GO:0098644 ! complex of collagen trimers +is_a: GO:0099081 ! supramolecular polymer + +[Term] +id: GO:0098646 +name: collagen sheet +namespace: cellular_component +def: "A protein complex that consists of collagen triple helices associated to form a sheet-like network." [GOC:dos, PMID:21421911] +synonym: "collagen hexagonal network" EXACT [PMID:21421911] +is_a: GO:0098645 ! collagen network + +[Term] +id: GO:0098647 +name: collagen beaded filament +namespace: cellular_component +def: "A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure." [GOC:dos, PMID:19693541] +synonym: "beads on a string" RELATED [PMID:19693541] +is_a: GO:0099512 ! supramolecular fiber + +[Term] +id: GO:0098648 +name: collagen anchoring fibril +namespace: cellular_component +def: "A specialised collagen fibril that functions as an anchor, binding to other collagen structures." [GOC:dos] +is_a: GO:0098644 ! complex of collagen trimers + +[Term] +id: GO:0098649 +name: obsolete response to peptidyl-dipeptidase A inhibitor +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidyl-dipeptidase A inhibitor stimulus." [GOC:dos] +comment: This term was obsoleted because it does not represent a physiological process. +synonym: "response to ACE inhibitor" NARROW [] +synonym: "response to angiotensin-converting enzyme inhibitor" NARROW [] +is_obsolete: true + +[Term] +id: GO:0098650 +name: peptidyl-proline 4-dioxygenase binding +namespace: molecular_function +def: "Binding to a peptidyl-proline 4-dioxygenase." [GOC:dos, GOC:kvm] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:0098651 +name: basement membrane collagen trimer +namespace: cellular_component +def: "Any collagen timer that is part of a basement membrane." [GOC:dos, PMID:21421911] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0005604 ! basement membrane + +[Term] +id: GO:0098652 +name: collagen type VII anchoring fibril +namespace: cellular_component +def: "An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis." [PMID:19693541] +is_a: GO:0098648 ! collagen anchoring fibril + +[Term] +id: GO:0098653 +name: centromere clustering +namespace: biological_process +alt_id: GO:0098587 +def: "The process by which centromeres/kinetochores become localized to clusters." [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732] +comment: As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process. +synonym: "kinetochore clustering" EXACT [] +is_a: GO:0050000 ! chromosome localization +is_a: GO:0072765 ! centromere localization + +[Term] +id: GO:0098654 +name: CENP-A recruiting complex +namespace: cellular_component +def: "A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere." [PMID:24774534] +synonym: "MIS18 complex" NARROW [GOC:bhm, GOC:vw] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098655 +name: cation transmembrane transport +namespace: biological_process +alt_id: GO:0099132 +def: "The process in which a cation is transported across a membrane." [GOC:dos, GOC:vw] +synonym: "ATP hydrolysis coupled cation transmembrane transport" NARROW [] +is_a: GO:0006812 ! cation transport +is_a: GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0098656 +name: anion transmembrane transport +namespace: biological_process +alt_id: GO:0099133 +def: "The process in which an anion is transported across a membrane." [GOC:dos, GOC:vw] +synonym: "ATP hydrolysis coupled anion transmembrane transport" NARROW [] +is_a: GO:0006820 ! anion transport +is_a: GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0098657 +name: import into cell +namespace: biological_process +def: "The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] +synonym: "uptake" BROAD [] +is_a: GO:0006810 ! transport + +[Term] +id: GO:0098658 +name: inorganic anion import across plasma membrane +namespace: biological_process +def: "The directed movement of inorganic anions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "inorganic anion import into cell" EXACT [] +is_a: GO:0098661 ! inorganic anion transmembrane transport +is_a: GO:0099587 ! inorganic ion import across plasma membrane + +[Term] +id: GO:0098659 +name: inorganic cation import across plasma membrane +namespace: biological_process +def: "The directed movement of inorganic cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "inorganic cation import into cell" EXACT [] +is_a: GO:0098662 ! inorganic cation transmembrane transport +is_a: GO:0099587 ! inorganic ion import across plasma membrane + +[Term] +id: GO:0098660 +name: inorganic ion transmembrane transport +namespace: biological_process +def: "The process in which an inorganic ion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "inorganic ion membrane transport" EXACT [] +synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0034220 ! ion transmembrane transport + +[Term] +id: GO:0098661 +name: inorganic anion transmembrane transport +namespace: biological_process +def: "The process in which an inorganic anion is transported across a membrane." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "inorganic anion membrane transport" EXACT [] +synonym: "transmembrane inorganic anion transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0015698 ! inorganic anion transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098660 ! inorganic ion transmembrane transport + +[Term] +id: GO:0098662 +name: inorganic cation transmembrane transport +namespace: biological_process +alt_id: GO:0015672 +alt_id: GO:0072511 +def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "divalent inorganic cation transport" NARROW [] +synonym: "inorganic cation membrane transport" EXACT [] +synonym: "monovalent inorganic cation transport" NARROW [] +synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb] +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098660 ! inorganic ion transmembrane transport + +[Term] +id: GO:0098663 +name: obsolete transmembrane transporter activity involved in import into cell +namespace: molecular_function +def: "OBSOLETE. Any transmembrane transporter activity that is involved in importing some substance into a cell." [GOC:dos] +comment: The reason for obsoletion is that this terms partly represents the process "import into cell". +is_obsolete: true + +[Term] +id: GO:0098664 +name: G protein-coupled serotonin receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands." [GOC:mah] +synonym: "G-protein coupled serotonin receptor signaling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +is_a: GO:0007210 ! serotonin receptor signaling pathway + +[Term] +id: GO:0098665 +name: serotonin receptor complex +namespace: cellular_component +def: "A protein complex that is capable of serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] +synonym: "5-HT receptor complex" EXACT [] +synonym: "5-hydroxytryptamine receptor complex" EXACT [] +synonym: "5HT receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0098666 +name: G protein-coupled serotonin receptor complex +namespace: cellular_component +def: "A protein complex that is capable of G protein-coupled serotonin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie] +synonym: "G-protein coupled serotonin receptor complex" EXACT [] +is_a: GO:0098665 ! serotonin receptor complex + +[Term] +id: GO:0098669 +name: superinfection exclusion +namespace: biological_process +def: "The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented." [PMID:11985726, PMID:23692331, PMID:24089557, PMID:8012757, VZ:3971] +xref: VZ:3971 +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0098670 +name: entry receptor-mediated virion attachment to host cell +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration." [PMID:18351291, VZ:3942] +synonym: "viral attachment to host entry receptor" EXACT [VZ:3942] +xref: VZ:3942 +is_a: GO:0046813 ! receptor-mediated virion attachment to host cell + +[Term] +id: GO:0098671 +name: adhesion receptor-mediated virion attachment to host cell +namespace: biological_process +def: "The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located." [PMID:18351291, VZ:3943] +synonym: "viral attachment to host adhesion receptor" EXACT [VZ:3943] +xref: VZ:3943 +is_a: GO:0046813 ! receptor-mediated virion attachment to host cell + +[Term] +id: GO:0098672 +name: inhibition of host CRISPR-cas system by virus +namespace: biological_process +def: "A process by which a virus inhibits the CRISPR-cas system of its host." [PMID:23242138, PMID:23446421, PMID:26416740] +synonym: "anti-CRISPR" BROAD [] +synonym: "CRISPR-cas system evasion by virus" EXACT [VZ:3962] +synonym: "evasion by virus of CRISPR-cas system" RELATED [] +xref: VZ:3962 +is_a: GO:0019049 ! mitigation of host defenses by virus + +[Term] +id: GO:0098673 +name: inhibition of host DNA replication by virus +namespace: biological_process +def: "Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication." [PMID:17010157, PMID:21205014] +is_a: GO:0019054 ! modulation by virus of host cellular process + +[Term] +id: GO:0098674 +name: extrinsic component of neuronal dense core vesicle membrane +namespace: cellular_component +def: "The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098922 ! extrinsic component of dense core granule membrane +relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane + +[Term] +id: GO:0098675 +name: intrinsic component of neuronal dense core vesicle membrane +namespace: cellular_component +def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to neuronal dense core granule membrane" EXACT [] +is_a: GO:0098956 ! intrinsic component of dense core granule membrane +relationship: part_of GO:0099012 ! neuronal dense core vesicle membrane + +[Term] +id: GO:0098676 +name: modulation of host virulence by virus +namespace: biological_process +def: "Any process by which a virus modulates the ability of its host to infect and/or damage an organism for which it is a host. Typically this involves a phage modulating the virulence of a bacterium. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production exotoxins or provide protection against host immune defenses." [PMID:10913072, PMID:11553559, PMID:23981100, VZ:3965] +xref: VZ:3965 +is_a: GO:0019048 ! modulation by virus of host process + +[Term] +id: GO:0098677 +name: virion maturation +namespace: biological_process +def: "Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection." [ISBN:0781718325, UniProtKB-KW:KW-0917, VZ:1946] +synonym: "viral particle maturation" EXACT [] +synonym: "virus particle maturation" RELATED [] +xref: UniProtKB-KW:KW-0917 +xref: VZ:1946 +is_a: GO:0016032 ! viral process +relationship: part_of GO:0019075 ! virus maturation + +[Term] +id: GO:0098678 +name: viral tropism switching +namespace: biological_process +def: "A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase." [PMID:6232613, VZ:4498] +xref: VZ:4498 +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0098679 +name: obsolete regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate catabloism." [PMID:16408318] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of carbohydrate catabolism by regulation of transcription from RNA polymerase II promoter" EXACT [] +is_obsolete: true + +[Term] +id: GO:0098680 +name: template-free RNA nucleotidyltransferase +namespace: molecular_function +def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:nc, PMID:15994230] +is_a: GO:0016779 ! nucleotidyltransferase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0098681 +name: synaptic ribbon +namespace: cellular_component +def: "A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical." [PMID:15626493] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0098682 +name: arciform density +namespace: cellular_component +def: "An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane." [PMID:15626493] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0097470 ! ribbon synapse + +[Term] +id: GO:0098683 +name: cochlear hair cell ribbon synapse +namespace: cellular_component +def: "A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density." [PMID:15626493] +subset: goslim_synapse +is_a: GO:0097470 ! ribbon synapse + +[Term] +id: GO:0098684 +name: photoreceptor ribbon synapse +namespace: cellular_component +def: "A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon." [PMID:15626493] +subset: goslim_synapse +is_a: GO:0097470 ! ribbon synapse + +[Term] +id: GO:0098685 +name: Schaffer collateral - CA1 synapse +namespace: cellular_component +def: "A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." [PMID:16399689] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098686 +name: hippocampal mossy fiber to CA3 synapse +namespace: cellular_component +def: "One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell." [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762] +subset: goslim_synapse +is_a: GO:0098984 ! neuron to neuron synapse + +[Term] +id: GO:0098687 +name: chromosomal region +namespace: cellular_component +def: "Any subdivision of a chromosome along its length." [GOC:dos] +comment: Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. +synonym: "chromosome region" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005694 ! chromosome + +[Term] +id: GO:0098688 +name: parallel fiber to Purkinje cell synapse +namespace: cellular_component +def: "An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells." [PMID:16623829, PMID:3209740] +subset: goslim_synapse +is_a: GO:0060076 ! excitatory synapse + +[Term] +id: GO:0098689 +name: latency-replication decision +namespace: biological_process +def: "The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic swtich controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli." [PMID:19416825, PMID:24339346, VZ:3964] +synonym: "Latency-replication switch" EXACT [] +synonym: "lytic switch" EXACT [] +synonym: "prophage induction" NARROW [] +synonym: "proviral induction" EXACT [] +synonym: "proviral switch" EXACT [] +synonym: "reactivation of latent virus" EXACT [] +xref: VZ:3964 +is_a: GO:0016032 ! viral process +relationship: regulates GO:0019046 ! release from viral latency + +[Term] +id: GO:0098690 +name: glycinergic synapse +namespace: cellular_component +def: "A synapse that uses glycine as a neurotransmitter." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098691 +name: dopaminergic synapse +namespace: cellular_component +def: "A synapse that uses dopamine as a neurotransmitter." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098692 +name: noradrenergic synapse +namespace: cellular_component +def: "A synapse that uses noradrenaline as a neurotransmitter." [GOC:dos] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098693 +name: regulation of synaptic vesicle cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle." [GOC:dos] +subset: goslim_synapse +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0098694 +name: regulation of synaptic vesicle budding from presynaptic endocytic zone membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane + +[Term] +id: GO:0098695 +name: inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels +namespace: molecular_function +def: "Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos] +subset: goslim_synapse +synonym: "IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT [] +is_a: GO:0005220 ! inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity + +[Term] +id: GO:0098696 +name: regulation of neurotransmitter receptor localization to postsynaptic specialization membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:1902473 ! regulation of protein localization to synapse +is_a: GO:1902683 ! regulation of receptor localization to synapse +is_a: GO:1904375 ! regulation of protein localization to cell periphery +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0099645 ! neurotransmitter receptor localization to postsynaptic specialization membrane + +[Term] +id: GO:0098697 +name: ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels +namespace: molecular_function +def: "Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005219 ! ryanodine-sensitive calcium-release channel activity + +[Term] +id: GO:0098698 +name: postsynaptic specialization assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0070925 ! organelle assembly +is_a: GO:0099084 ! postsynaptic specialization organization +relationship: part_of GO:0099068 ! postsynapse assembly + +[Term] +id: GO:0098699 +name: structural constituent of presynaptic actin cytoskeleton +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005200 ! structural constituent of cytoskeleton +is_a: GO:0099181 ! structural constituent of presynapse + +[Term] +id: GO:0098700 +name: neurotransmitter loading into synaptic vesicle +namespace: biological_process +def: "The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps." [GOC:bf, GOC:pad, GOC:PARL, PMID:10099709, PMID:15217342] +subset: goslim_synapse +synonym: "neurotransmitter import into synaptic vesicle" EXACT [] +synonym: "neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342] +synonym: "synaptic vesicle neurotransmitter loading" EXACT syngo_official_label [] +is_a: GO:0006836 ! neurotransmitter transport +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0099504 ! synaptic vesicle cycle + +[Term] +id: GO:0098702 +name: adenine import across plasma membrane +namespace: biological_process +alt_id: GO:0061488 +def: "The directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "adenine import into cell" EXACT [] +is_a: GO:0015853 ! adenine transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1904823 ! purine nucleobase transmembrane transport + +[Term] +id: GO:0098703 +name: calcium ion import across plasma membrane +namespace: biological_process +alt_id: GO:1990035 +def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "calcium ion import into cell" EXACT [] +synonym: "calcium ion uptake into cell" EXACT [GOC:vw] +is_a: GO:0097553 ! calcium ion transmembrane import into cytosol +is_a: GO:0098659 ! inorganic cation import across plasma membrane +is_a: GO:1902656 ! calcium ion import into cytosol + +[Term] +id: GO:0098704 +name: carbohydrate import across plasma membrane +namespace: biological_process +alt_id: GO:0097319 +def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "carbohydrate import into cell" EXACT [] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0098705 +name: copper ion import across plasma membrane +namespace: biological_process +alt_id: GO:0015678 +alt_id: GO:1902861 +def: "The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "copper cation import into cell" EXACT [] +synonym: "copper ion import into cell" EXACT [] +synonym: "high affinity copper ion transport" NARROW [] +synonym: "high affinity copper transport" NARROW [] +synonym: "high-affinity copper ion transport" NARROW [] +is_a: GO:0015677 ! copper ion import +is_a: GO:0015679 ! plasma membrane copper ion transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:0098706 +name: iron ion import across cell outer membrane +namespace: biological_process +alt_id: GO:0015683 +alt_id: GO:0097461 +def: "The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space." [GOC:mah, PMID:23192658] +synonym: "ferric ion import into cell" EXACT [GOC:mah] +synonym: "ferric iron import across cell outer membrane" NARROW [] +synonym: "ferric iron import into cell" EXACT [] +synonym: "ferric iron transmembrane transport" BROAD [] +synonym: "high affinity ferric iron transport" NARROW [] +synonym: "high-affinity ferric iron transmembrane transport" NARROW [] +is_a: GO:0034755 ! iron ion transmembrane transport + +[Term] +id: GO:0098708 +name: glucose import across plasma membrane +namespace: biological_process +alt_id: GO:0061490 +alt_id: GO:1990821 +def: "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "glucose import into cell" EXACT [] +synonym: "high affinity glucose import" NARROW [] +is_a: GO:0046323 ! glucose import +is_a: GO:0140271 ! hexose import across plasma membrane + +[Term] +id: GO:0098709 +name: glutathione import across plasma membrane +namespace: biological_process +alt_id: GO:0036347 +def: "The directed movement of glutathione from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "glutathione import into cell" EXACT [] +synonym: "glutathione uptake" EXACT [GOC:bf] +is_a: GO:0034775 ! glutathione transmembrane transport +is_a: GO:0140207 ! tripeptide import across plasma membrane + +[Term] +id: GO:0098710 +name: guanine import across plasma membrane +namespace: biological_process +alt_id: GO:0061489 +def: "The directed movement of guanine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "guanine import into cell" EXACT [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1903716 ! guanine transmembrane transport + +[Term] +id: GO:0098711 +name: iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:0097459 +alt_id: GO:0097460 +alt_id: GO:0098707 +def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:mah, PMID:8321236] +synonym: "ferrous ion import into cell" RELATED [GOC:mah] +synonym: "ferrous iron import across plasma membrane" RELATED [] +synonym: "ferrous iron import into cell" RELATED [] +synonym: "iron import into cell" RELATED [GOC:mah] +synonym: "iron ion import into cell" EXACT [] +is_a: GO:0033212 ! iron import into cell +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:0098712 +name: L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1903802 +alt_id: GO:1990123 +def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "L-glutamate import into cell" EXACT [] +synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] +synonym: "L-glutamate(1-) import into cell" EXACT [] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0051938 ! L-glutamate import +is_a: GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:0098713 +name: leucine import across plasma membrane +namespace: biological_process +alt_id: GO:1990122 +def: "The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "L-leucine import into cell" NARROW [GOC:mah] +synonym: "leucine import into cell" EXACT [] +is_a: GO:0015820 ! leucine transport +is_a: GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:0098714 +name: malate import across plasma membrane +namespace: biological_process +alt_id: GO:0097405 +def: "The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "malate import into cell" EXACT [] +is_a: GO:0071423 ! malate transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0098715 +name: malonic acid import across plasma membrane +namespace: biological_process +alt_id: GO:0097406 +def: "The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "malonate import into cell" EXACT [] +synonym: "malonic acid import into cell" EXACT [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1901553 ! malonic acid transmembrane transport + +[Term] +id: GO:0098716 +name: nickel cation import across plasma membrane +namespace: biological_process +alt_id: GO:0090509 +def: "The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "nickel cation import into cell" EXACT [] +is_a: GO:0035444 ! nickel cation transmembrane transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:0098717 +name: pantothenate import across plasma membrane +namespace: biological_process +alt_id: GO:0044755 +alt_id: GO:1901688 +def: "The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "pantothenate import" RELATED [] +synonym: "pantothenate import into cell" EXACT [] +is_a: GO:0015887 ! pantothenate transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0098718 +name: serine import across plasma membrane +namespace: biological_process +alt_id: GO:0061491 +def: "The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "serine import into cell" EXACT [] +is_a: GO:0032329 ! serine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0098719 +name: sodium ion import across plasma membrane +namespace: biological_process +alt_id: GO:0097369 +alt_id: GO:1990118 +def: "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "sodium import" EXACT [] +synonym: "sodium ion import" RELATED [] +synonym: "sodium ion import into cell" EXACT [] +is_a: GO:0035725 ! sodium ion transmembrane transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:0098720 +name: succinate import across plasma membrane +namespace: biological_process +alt_id: GO:0097404 +def: "The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "succinate import into cell" EXACT [] +is_a: GO:0071422 ! succinate transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0098721 +name: uracil import across plasma membrane +namespace: biological_process +alt_id: GO:1902431 +def: "The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "uracil import into cell" EXACT [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1903791 ! uracil transmembrane transport + +[Term] +id: GO:0098722 +name: asymmetric stem cell division +namespace: biological_process +def: "Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity." [GOC:dos, PMID:18513950] +is_a: GO:0008356 ! asymmetric cell division +is_a: GO:0017145 ! stem cell division + +[Term] +id: GO:0098723 +name: skeletal muscle myofibril +namespace: cellular_component +def: "A myofibril of a skeletal muscle fiber." [GOC:dos] +is_a: GO:0030016 ! myofibril + +[Term] +id: GO:0098724 +name: symmetric stem cell division +namespace: biological_process +def: "Symmetric division of a stem cell to produce two stem cells of the same type as the parent. Symmetric stem cell division is necessary for amplification of stem cell populations in the absence of sources of stem cells external to an existing population." [PMID:19948499, PMID:23303905] +comment: Examples include the self-renewal of spermatogonial stem cells and (some) division during amplification of skeletal muscle satellite cell populations. +is_a: GO:0017145 ! stem cell division +is_a: GO:0098725 ! symmetric cell division + +[Term] +id: GO:0098725 +name: symmetric cell division +namespace: biological_process +def: "Cell division in which both daughter cells are of the same type." [GOC:dos] +is_a: GO:0051301 ! cell division + +[Term] +id: GO:0098726 +name: symmetric division of skeletal muscle satellite stem cell +namespace: biological_process +def: "The symmetric division of a skeletal muscle satellite stem cell, resulting in two skeletal muscle satellite stem cells. This process is involved in amplification of the pool of these cells." [PMID:23303905] +is_a: GO:0048103 ! somatic stem cell division +is_a: GO:0098724 ! symmetric stem cell division + +[Term] +id: GO:0098727 +name: maintenance of cell number +namespace: biological_process +def: "Any process by which the numbers of cells of a particular type or in a tissue are maintained." [GOC:dos] +is_a: GO:0032502 ! developmental process + +[Term] +id: GO:0098728 +name: germline stem cell asymmetric division +namespace: biological_process +def: "The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes." [GOC:dos] +is_a: GO:0042078 ! germ-line stem cell division +is_a: GO:0098722 ! asymmetric stem cell division + +[Term] +id: GO:0098729 +name: germline stem cell symmetric division +namespace: biological_process +def: "Division of a germline stem cell to produce two germline stem cells of the same type as the parent." [GOC:dos, PMID:19948499] +is_a: GO:0042078 ! germ-line stem cell division +is_a: GO:0098724 ! symmetric stem cell division + +[Term] +id: GO:0098730 +name: male germline stem cell symmetric division +namespace: biological_process +def: "The symmetric division of a male germline stem cell to produce two male germline stem cells. An example of this is found in mammalian spermatogonial stem cells, some proportion of which divide symmetrically, so amplifying the population. The choice between asymmetric and symmetric division in this case appears to be internal and stochastic." [GOC:dos, PMID:19948499] +is_a: GO:0098729 ! germline stem cell symmetric division + +[Term] +id: GO:0098731 +name: skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells." [PMID:23303905] +is_a: GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration +is_a: GO:0035019 ! somatic stem cell population maintenance + +[Term] +id: GO:0098732 +name: macromolecule deacylation +namespace: biological_process +def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule." [GOC:dos] +is_a: GO:0043412 ! macromolecule modification + +[Term] +id: GO:0098733 +name: hemidesmosome associated protein complex +namespace: cellular_component +def: "Any protein complex that is part of or has some part in a hemidesmosome." [GOC:dos] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098734 +name: macromolecule depalmitoylation +namespace: biological_process +def: "The removal of palymitoyl groups from a macromolecule." [GOC:dos] +is_a: GO:0098732 ! macromolecule deacylation + +[Term] +id: GO:0098735 +name: positive regulation of the force of heart contraction +namespace: biological_process +def: "Any process that increases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280] +is_a: GO:0002026 ! regulation of the force of heart contraction + +[Term] +id: GO:0098736 +name: negative regulation of the force of heart contraction +namespace: biological_process +def: "Any process that decreases the force of heart muscle contraction." [GOC:BHF, GOC:dos, GOC:mtg_cardiac_conduct_nov11, GOC:rl, PMID:17242280] +is_a: GO:0002026 ! regulation of the force of heart contraction + +[Term] +id: GO:0098737 +name: protein insertion into plasma membrane +namespace: biological_process +def: "The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:DOS] +is_a: GO:0051205 ! protein insertion into membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0098739 +name: import across plasma membrane +namespace: biological_process +def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "uptake" BROAD [] +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0098740 +name: obsolete multi organism cell adhesion +namespace: biological_process +def: "OBSOLETE. Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms." [GOC:dos] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0098742 +name: cell-cell adhesion via plasma-membrane adhesion molecules +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos] +is_a: GO:0098609 ! cell-cell adhesion + +[Term] +id: GO:0098743 +name: cell aggregation +namespace: biological_process +def: "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0098744 +name: 1-phosphatidylinositol 4-kinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of 1-phosphatidylinositol 4-kinase." [PMID:21288895] +is_a: GO:0019209 ! kinase activator activity + +[Term] +id: GO:0098745 +name: Dcp1-Dcp2 complex +namespace: cellular_component +def: "A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA." [GOC:dos, GOC:vw, PMID:22323607] +comment: Additional components may be present, for example in ascomycetes this complex includes an additional regulatory subunit, Edc1. +is_a: GO:0034518 ! RNA cap binding complex + +[Term] +id: GO:0098746 +name: fast, calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release." [GOC:dos, GOC:pad, GOC:PARL, PMID:4405553, PMID:7809151, PMID:7954835] +synonym: "synchronous, calcium ion-dependent exocytosis of neurotransmitter" EXACT [PMID:7954835] +is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter + +[Term] +id: GO:0098747 +name: slow, calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release." [GOC:dos, GOC:pad, GOC:parl, PMID:7809151, PMID:7954835] +is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter + +[Term] +id: GO:0098749 +name: cerebellar neuron development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] +is_a: GO:0048666 ! neuron development +relationship: part_of GO:0021549 ! cerebellum development + +[Term] +id: GO:0098750 +name: FYXD domain binding +namespace: molecular_function +def: "Binding to a FXYD domain." [GOC:dos, GOC:mr, PMID:10950925, PMID:16403837, PMID:18000745] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0098751 +name: bone cell development +namespace: biological_process +def: "The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dos] +comment: Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. +subset: gocheck_do_not_annotate +is_a: GO:0048468 ! cell development +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:0098752 +name: integral component of the cytoplasmic side of the plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane." [GOC:dos] +is_a: GO:0005887 ! integral component of plasma membrane +is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane + +[Term] +id: GO:0098753 +name: anchored component of the cytoplasmic side of the plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane." [GOC:dos] +comment: Examples include many myristoylated proteins. +is_a: GO:0031235 ! intrinsic component of the cytoplasmic side of the plasma membrane +is_a: GO:0046658 ! anchored component of plasma membrane + +[Term] +id: GO:0098754 +name: detoxification +namespace: biological_process +def: "Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:dos] +subset: goslim_generic +subset: goslim_pombe +is_a: GO:0008150 ! biological_process +relationship: part_of GO:0009636 ! response to toxic substance + +[Term] +id: GO:0098755 +name: maintenance of seed dormancy by absisic acid +namespace: biological_process +def: "The process by which seed dormancy is maintained by the presence of absisic acid." [GOC:dos, PMID:9580097] +is_a: GO:0010231 ! maintenance of seed dormancy +relationship: part_of GO:0009737 ! response to abscisic acid + +[Term] +id: GO:0098756 +name: response to interleukin-21 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah] +synonym: "response to IL-21" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0098757 +name: cellular response to interleukin-21 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus." [GOC:BHF, GOC:mah] +synonym: "cellular response to IL-21" EXACT [GOC:mah] +is_a: GO:0098756 ! response to interleukin-21 + +[Term] +id: GO:0098758 +name: response to interleukin-8 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah] +synonym: "response to IL-8" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0098759 +name: cellular response to interleukin-8 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus." [GOC:BHF, GOC:mah] +synonym: "cellular response to IL-8" EXACT [GOC:mah] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:0098758 ! response to interleukin-8 + +[Term] +id: GO:0098760 +name: response to interleukin-7 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] +synonym: "response to IL-7" EXACT [GOC:mah] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:0098761 +name: cellular response to interleukin-7 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus." [GOC:BHF, GOC:mah] +synonym: "cellular response to IL-7" EXACT [GOC:mah] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:0098760 ! response to interleukin-7 + +[Term] +id: GO:0098762 +name: meiotic cell cycle phase +namespace: biological_process +def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] +comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0098763 +name: mitotic cell cycle phase +namespace: biological_process +def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] +comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0022403 ! cell cycle phase + +[Term] +id: GO:0098764 +name: meiosis I cell cycle phase +namespace: biological_process +def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] +comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0098762 ! meiotic cell cycle phase + +[Term] +id: GO:0098765 +name: meiosis II cell cycle phase +namespace: biological_process +def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos] +comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0098762 ! meiotic cell cycle phase + +[Term] +id: GO:0098766 +name: obsolete meiosis I M phase +namespace: biological_process +def: "OBSOLETE. M phase during meiosis I." [GOC:dos] +comment: Obsoleted because added in error. +is_obsolete: true +consider: GO:0098762 + +[Term] +id: GO:0098767 +name: obsolete meiosis II M phase +namespace: biological_process +def: "OBSOLETE. M phase during meiosis II." [GOC:dos] +comment: Obsoleted because added in error. +is_obsolete: true +consider: GO:0098762 + +[Term] +id: GO:0098768 +name: meiotic prometaphase I +namespace: biological_process +def: "The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate." [PMID:16012859] +comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). +subset: gocheck_do_not_annotate +is_a: GO:0098764 ! meiosis I cell cycle phase + +[Term] +id: GO:0098769 +name: TIMP family protein binding +namespace: molecular_function +def: "Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family." [PMID:22078297] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0098770 +name: FBXO family protein binding +namespace: molecular_function +def: "Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction." [PMID:11178263] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0098771 +name: inorganic ion homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell." [GOC:dos] +is_a: GO:0050801 ! ion homeostasis + +[Term] +id: GO:0098772 +name: molecular function regulator +namespace: molecular_function +def: "A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition." [GOC:dos, GOC:pt] +subset: gocheck_do_not_annotate +subset: goslim_flybase_ribbon +subset: goslim_generic +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0098773 +name: skin epidermis development +namespace: biological_process +def: "The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure." [GOC:dos] +is_a: GO:0008544 ! epidermis development +is_a: GO:0060429 ! epithelium development +relationship: part_of GO:0043588 ! skin development + +[Term] +id: GO:0098774 +name: curli +namespace: cellular_component +def: "A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization." [PMID:16704339] +synonym: "tafi" NARROW [PMID:16704339] +synonym: "thin aggregative fimbrae" NARROW [PMID:16704339] +is_a: GO:0009289 ! pilus +relationship: part_of GO:0097311 ! bacterial biofilm matrix + +[Term] +id: GO:0098775 +name: curli assembly +namespace: biological_process +def: "The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex." [PMID:16704339] +is_a: GO:0009297 ! pilus assembly + +[Term] +id: GO:0098776 +name: protein transport across the cell outer membrane +namespace: biological_process +def: "The directed movement of proteins across the cell outer membrane." [GOC:dos] +is_a: GO:0071806 ! protein transmembrane transport + +[Term] +id: GO:0098777 +name: protein secretion by the type VIII secretion system +namespace: biological_process +def: "Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits." [PMID:19299134, PMID:24080089] +comment: This term is defined so as to leave open the possibility that things other than curli subunits are secreted via same secretory system as that used by curli subunits. +synonym: "T8SS" EXACT [PMID:19299134] +is_a: GO:0098776 ! protein transport across the cell outer membrane + +[Term] +id: GO:0098778 +name: curli subunit secretion coupled to curli assembly +namespace: biological_process +def: "The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface." [PMID:24080089] +synonym: "extracellular nucleation-precipitation pathway" EXACT [PMID:19299134] +is_a: GO:0098777 ! protein secretion by the type VIII secretion system +relationship: part_of GO:0098775 ! curli assembly + +[Term] +id: GO:0098779 +name: positive regulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GOC:PARL, PMID:18200046, PMID:23985961] +synonym: "positive regulation of macromitophagy in response to mitochondrial depolarization" EXACT [] +is_a: GO:1904925 ! positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization +relationship: positively_regulates GO:0000423 ! mitophagy + +[Term] +id: GO:0098780 +name: response to mitochondrial depolarisation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria." [GOC:dos] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0098781 +name: ncRNA transcription +namespace: biological_process +def: "The transcription of non (protein) coding RNA from a DNA template." [GOC:dos] +is_a: GO:0006351 ! transcription, DNA-templated + +[Term] +id: GO:0098782 +name: mechanosensitived potassium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a channel that opens in response to a mechanical stress." [PMID:22282805, PMID:25471887, PMID:25500157] +synonym: "mechanically-gated potassium channel activity" EXACT [] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0140135 ! mechanosensitive cation channel activity + +[Term] +id: GO:0098784 +name: biofilm matrix organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix." [GOC:mah] +synonym: "biofilm matrix organization and biogenesis" RELATED [GOC:dos] +is_a: GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:0098785 +name: biofilm matrix assembly +namespace: biological_process +def: "A process that results in the assembly of a biofilm matrix." [GOC:mah] +is_a: GO:0085029 ! extracellular matrix assembly +is_a: GO:0098784 ! biofilm matrix organization +relationship: part_of GO:0042710 ! biofilm formation + +[Term] +id: GO:0098786 +name: biofilm matrix disassembly +namespace: biological_process +def: "A process that results in the disassembly of a biofilm matrix." [GOC:mah] +is_a: GO:0022617 ! extracellular matrix disassembly +is_a: GO:0098784 ! biofilm matrix organization + +[Term] +id: GO:0098787 +name: mRNA cleavage involved in mRNA processing +namespace: biological_process +def: "Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide." [GOC:dos] +is_a: GO:0006379 ! mRNA cleavage +relationship: part_of GO:0006397 ! mRNA processing + +[Term] +id: GO:0098788 +name: dendritic knob +namespace: cellular_component +def: "The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium." [PMID:20801626] +synonym: "apical dendritic knob" EXACT [] +is_a: GO:0044292 ! dendrite terminus + +[Term] +id: GO:0098789 +name: pre-mRNA cleavage required for polyadenylation +namespace: biological_process +def: "The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation." [http://www.ncbi.nlm.nih.gov/books/NBK21563/#_A2878_] +synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] +synonym: "pre-mRNA cleavage factor activity" EXACT [] +is_a: GO:0098787 ! mRNA cleavage involved in mRNA processing +relationship: part_of GO:0031124 ! mRNA 3'-end processing + +[Term] +id: GO:0098790 +name: ncRNA transcription associated with protein coding gene TSS/TES +namespace: biological_process +def: "The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes." [PMID:20502517] +synonym: "pasRNA transcription" NARROW [PMID:20502517] +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0098791 +name: Golgi apparatus subcompartment +namespace: cellular_component +def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus." [GOC:dos] +synonym: "Golgi subcompartment" EXACT [] +is_a: GO:0031984 ! organelle subcompartment +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:0098792 +name: xenophagy +namespace: biological_process +def: "The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents." [GOC:autophagy, GOC:pad, GOC:PARL, PMID:19802565, PMID:20159618, PMID:25497060] +comment: While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation. +is_a: GO:0061912 ! selective autophagy +relationship: part_of GO:0098542 ! defense response to other organism + +[Term] +id: GO:0098793 +name: presynapse +namespace: cellular_component +def: "The part of a synapse that is part of the presynaptic cell." [GOC:dos] +subset: goslim_synapse +synonym: "presynaptic terminal" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045202 ! synapse + +[Term] +id: GO:0098794 +name: postsynapse +namespace: cellular_component +def: "The part of a synapse that is part of the post-synaptic cell." [GOC:dos] +subset: goslim_synapse +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045202 ! synapse + +[Term] +id: GO:0098795 +name: mRNA destabilization-mediated gene silencing +namespace: biological_process +def: "A gene silencing mechanism that involves the destabilization of an mRNA." [GOC:BHF, GOC:BHF_miRNA, GOC:dos] +synonym: "mRNA cleavage involved in gene silencing" EXACT [] +is_a: GO:0016441 ! posttranscriptional gene silencing + +[Term] +id: GO:0098796 +name: membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of a membrane." [GOC:dos] +subset: goslim_metagenomics +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0016020 ! membrane + +[Term] +id: GO:0098797 +name: plasma membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of the plasma membrane." [GOC:dos] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:0098798 +name: mitochondrial protein-containing complex +namespace: cellular_component +def: "A protein complex that is part of a mitochondrion." [GOC:dos] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "mitochondrial protein complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005739 ! mitochondrion + +[Term] +id: GO:0098799 +name: outer mitochondrial membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of the outer mitochondrial membrane." [GOC:dos] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005741 ! mitochondrial outer membrane + +[Term] +id: GO:0098800 +name: inner mitochondrial membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0098801 +name: regulation of renal system process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system." [GOC:dos] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0003014 ! renal system process + +[Term] +id: GO:0098802 +name: plasma membrane signaling receptor complex +namespace: cellular_component +def: "Any protein complex that is part of the plasma membrane and which functions as a signaling receptor." [GOC:dos] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0043235 ! receptor complex +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:0098803 +name: respiratory chain complex +namespace: cellular_component +def: "Any protein complex that is part of a respiratory chain." [GOC:dos] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0070469 ! respirasome + +[Term] +id: GO:0098804 +name: non-motile cilium membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding a non-motile cilium." [GOC:cilia, GOC:dos] +synonym: "nonmotile primary cilium membrane" RELATED [] +is_a: GO:0060170 ! ciliary membrane +relationship: part_of GO:0097730 ! non-motile cilium + +[Term] +id: GO:0098806 +name: mRNA deadenylation-mediated gene silencing by miRNA +namespace: biological_process +def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA following miRNA binding to mRNA, resulting in destabilization of the mRNA and a reduction in the efficiency of its translation." [GOC:BHF, GOC:dos, PMID:21118121, PMID:23209154] +synonym: "deadenylation involved in gene silencing by miRNA" EXACT [] +is_a: GO:0035279 ! miRNA-mediated gene silencing by mRNA destabilization + +[Term] +id: GO:0098807 +name: chloroplast thylakoid membrane protein complex +namespace: cellular_component +def: "A protein complex that is part of a chloroplast thylakoid membrane." [GOC:dos] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0009535 ! chloroplast thylakoid membrane + +[Term] +id: GO:0098808 +name: mRNA cap binding +namespace: molecular_function +def: "Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule." [GOC:dos] +is_a: GO:0000339 ! RNA cap binding +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:0098809 +name: nitrite reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor." [GOC:dos, GOC:jh] +is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors + +[Term] +id: GO:0098810 +name: neurotransmitter reuptake +namespace: biological_process +def: "The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0098811 +name: obsolete transcriptional repressor activity, RNA polymerase II activating transcription factor binding +namespace: molecular_function +def: "OBSOLETE. Binding to an RNA polymerase II activating transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription." [GOC:BHF, GOC:dos, GOC:rl, GOC:txnOH] +comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. +synonym: "RNA polymerase II activating transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT [] +synonym: "RNA polymerase II activating transcription factor binding transcription repressor activity" EXACT [] +synonym: "RNA polymerase II transcription repressor activity" BROAD [] +is_obsolete: true +consider: GO:0001227 + +[Term] +id: GO:0098812 +name: nuclear rRNA polyadenylation involved in polyadenylation-dependent rRNA catabolic process +namespace: biological_process +def: "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a rRNA, occurring as part of the process of polyadenylation-dependent rRNA catabolism in the nucleus." [GOC:dph, GOC:jl, GOC:tb] +synonym: "nuclear rRNA polyadenylation during polyadenylation-dependent rRNA catabolic process" RELATED [GOC:dph, GOC:tb] +synonym: "nuclear rRNA polyadenylation involved in poly(A)-dependent rRNA catabolic process" RELATED [GOC:vw] +is_a: GO:0016072 ! rRNA metabolic process +is_a: GO:0043630 ! ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process +relationship: part_of GO:0071035 ! nuclear polyadenylation-dependent rRNA catabolic process + +[Term] +id: GO:0098813 +name: nuclear chromosome segregation +namespace: biological_process +def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] +is_a: GO:0007059 ! chromosome segregation +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0098814 +name: spontaneous synaptic transmission +namespace: biological_process +def: "The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential." [PMID:20200227] +comment: This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs). +subset: goslim_synapse +synonym: "basal synaptic transmission" EXACT [PMID:16899074] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0098815 +name: modulation of excitatory postsynaptic potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:dos] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0042391 ! regulation of membrane potential +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0060079 ! excitatory postsynaptic potential + +[Term] +id: GO:0098816 +name: mini excitatory postsynaptic potential +namespace: biological_process +def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse." [GOC:dos] +is_a: GO:0060079 ! excitatory postsynaptic potential + +[Term] +id: GO:0098817 +name: evoked excitatory postsynaptic potential +namespace: biological_process +def: "A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse." [GOC:dos] +is_a: GO:0060079 ! excitatory postsynaptic potential + +[Term] +id: GO:0098818 +name: hyperpolarization of postsynaptic membrane +namespace: biological_process +def: "A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold." [GOC:dos] +is_a: GO:0060078 ! regulation of postsynaptic membrane potential + +[Term] +id: GO:0098819 +name: depolarization of postsynaptic membrane +namespace: biological_process +def: "A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold." [GOC:dos] +is_a: GO:0060078 ! regulation of postsynaptic membrane potential + +[Term] +id: GO:0098820 +name: trans-synaptic protein complex +namespace: cellular_component +def: "A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes." [PMID:20200227] +subset: goslim_synapse +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0098821 +name: BMP receptor activity +namespace: molecular_function +def: "Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity." [GOC:BHF, GOC:dos] +is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity + +[Term] +id: GO:0098822 +name: peptidyl-cysteine modification to L-cysteine persulfide +namespace: biological_process +def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide." [PMID:11592406] +xref: RESID:AA0269 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0098823 +name: peptidyl-cysteine modification to S-amindino-L-cysteine +namespace: biological_process +def: "The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine." [RESID:AA0335] +xref: RESID:AA0335 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0098824 +name: peptidyl-cysteine sulfation +namespace: biological_process +def: "The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] +xref: RESID:AA0171 +is_a: GO:0018198 ! peptidyl-cysteine modification + +[Term] +id: GO:0098825 +name: peptidyl-histidine guanylation +namespace: biological_process +def: "The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine." [RESID:AA0325] +xref: RESID:AA0325 +is_a: GO:0018117 ! protein adenylylation +is_a: GO:0018202 ! peptidyl-histidine modification + +[Term] +id: GO:0098826 +name: endoplasmic reticulum tubular network membrane +namespace: cellular_component +def: "The membrane of the endoplasmic reticulum tubular network." [PMID:16469703] +is_a: GO:0005789 ! endoplasmic reticulum membrane +relationship: part_of GO:0071782 ! endoplasmic reticulum tubular network + +[Term] +id: GO:0098827 +name: endoplasmic reticulum subcompartment +namespace: cellular_component +def: "A distinct region of the endoplasmic reticulum." [GOC:dos] +is_a: GO:0031984 ! organelle subcompartment +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0098828 +name: modulation of inhibitory postsynaptic potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential." [GOC:dos] +synonym: "regulation of inhibitory postsynaptic potential" EXACT [] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0042391 ! regulation of membrane potential +relationship: regulates GO:0060080 ! inhibitory postsynaptic potential + +[Term] +id: GO:0098829 +name: intestinal folate absorption +namespace: biological_process +def: "Uptake of folic into the blood by absorption from the small intestine." [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432] +is_a: GO:0015884 ! folic acid transport +is_a: GO:0050892 ! intestinal absorption + +[Term] +id: GO:0098830 +name: presynaptic endosome +namespace: cellular_component +def: "An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles." [PMID:20200227, PMID:25939282] +comment: As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details. +subset: goslim_synapse +is_a: GO:0005768 ! endosome +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0098831 +name: presynaptic active zone cytoplasmic component +namespace: cellular_component +def: "A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles." [GOC:dos] +subset: goslim_synapse +synonym: "cortex of presynaptic active zone" EXACT [] +synonym: "presynaptic zone cortex" EXACT [] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:0098832 +name: peri-centrosomal recycling endosome +namespace: cellular_component +def: "A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes." [PMID:19696797, PMID:20820847] +is_a: GO:0055037 ! recycling endosome + +[Term] +id: GO:0098833 +name: presynaptic endocytic zone +namespace: cellular_component +def: "A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity." [PMID:17455288] +comment: May be identical to periactive zone? +subset: goslim_synapse +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0098834 +name: presynaptic endocytic zone cytoplasmic component +namespace: cellular_component +def: "The cytoplasmic component of the presynaptic endocytic zone." [GOC:dos] +subset: goslim_synapse +synonym: "cortex of presynaptic endocytic zone" EXACT [] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0098833 ! presynaptic endocytic zone + +[Term] +id: GO:0098835 +name: presynaptic endocytic zone membrane +namespace: cellular_component +def: "The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release." [GOC:dos] +subset: goslim_synapse +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0042734 ! presynaptic membrane +relationship: part_of GO:0098833 ! presynaptic endocytic zone + +[Term] +id: GO:0098836 +name: cytoskeleton of dendritic spine +namespace: cellular_component +def: "The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling." [PMID:24854120] +is_a: GO:0099571 ! postsynaptic cytoskeleton +relationship: part_of GO:0043197 ! dendritic spine + +[Term] +id: GO:0098837 +name: postsynaptic recycling endosome +namespace: cellular_component +def: "A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation." [PMID:20820847] +subset: goslim_synapse +synonym: "postsynaptic endosomal recycling compartment" BROAD [PMID:20820847] +synonym: "postsynaptic recycling outpost" EXACT [PMID:20820847] +is_a: GO:0055037 ! recycling endosome +is_a: GO:0098845 ! postsynaptic endosome + +[Term] +id: GO:0098838 +name: folate transmembrane transport +namespace: biological_process +def: "The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane." [PMID:24745983] +synonym: "folic acid transmembrane transport" RELATED [] +synonym: "reduced folate transmembrane transport" NARROW [] +is_a: GO:0015884 ! folic acid transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:0098839 +name: postsynaptic density membrane +namespace: cellular_component +def: "The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099634 ! postsynaptic specialization membrane +relationship: part_of GO:0014069 ! postsynaptic density + +[Term] +id: GO:0098840 +name: protein transport along microtubule +namespace: biological_process +def: "The directed movement of a protein along a microtubule, mediated by motor proteins." [PMID:25987607] +synonym: "microtubule-based protein transport" BROAD [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0010970 ! transport along microtubule +is_a: GO:0099118 ! microtubule-based protein transport + +[Term] +id: GO:0098841 +name: protein localization to cell division site after cytokinesis +namespace: biological_process +def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis." [PMID:25411334] +is_a: GO:0072741 ! protein localization to cell division site + +[Term] +id: GO:0098842 +name: postsynaptic early endosome +namespace: cellular_component +def: "An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling." [PMID:19603039, PMID:20820847, PMID:24727350] +comment: Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1. +subset: goslim_synapse +is_a: GO:0005769 ! early endosome +is_a: GO:0098845 ! postsynaptic endosome + +[Term] +id: GO:0098843 +name: postsynaptic endocytic zone +namespace: cellular_component +def: "A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins." [PMID:17880892] +subset: goslim_synapse +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0098844 +name: postsynaptic endocytic zone membrane +namespace: cellular_component +def: "The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta." [PMID:17880892] +subset: goslim_synapse +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0045211 ! postsynaptic membrane +relationship: part_of GO:0098843 ! postsynaptic endocytic zone + +[Term] +id: GO:0098845 +name: postsynaptic endosome +namespace: cellular_component +def: "An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse." [PMID:20820847] +subset: goslim_synapse +is_a: GO:0005768 ! endosome +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0098846 +name: podocyte foot +namespace: cellular_component +def: "A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms." [PMID:25324828] +synonym: "pedicel" EXACT [Wikipedia:Podocyte] +synonym: "podocyte foot process" EXACT [PMID:25324828] +synonym: "secondary podocyte projection" EXACT [] +xref: Wikipedia:Podocyte +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0098847 +name: sequence-specific single stranded DNA binding +namespace: molecular_function +def: "Binding to single-stranded DNA of a specific nucleotide composition." [PMID:9531483] +is_a: GO:0003697 ! single-stranded DNA binding +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:0098848 +name: alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane." [EC:4.7.1.1, GOC:dos, GOC:ik] +synonym: "alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming)" RELATED [EC:4.7.1.1] +xref: EC:4.7.1.1 +xref: RHEA:34707 +is_a: GO:0018835 ! carbon phosphorus lyase activity + +[Term] +id: GO:0098849 +name: cellular detoxification of cadmium ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [GOC:dos, GOC:vw] +is_a: GO:0071585 ! detoxification of cadmium ion +is_a: GO:1990748 ! cellular detoxification +relationship: part_of GO:0071276 ! cellular response to cadmium ion + +[Term] +id: GO:0098850 +name: extrinsic component of synaptic vesicle membrane +namespace: cellular_component +def: "The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0030672 ! synaptic vesicle membrane + +[Term] +id: GO:0098851 +name: double-stranded miRNA binding +namespace: molecular_function +def: "Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19966796] +synonym: "miRNA duplex binding" EXACT [] +is_a: GO:0003725 ! double-stranded RNA binding + +[Term] +id: GO:0098852 +name: lytic vacuole membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell." [GOC:dos] +is_a: GO:0005774 ! vacuolar membrane +relationship: part_of GO:0000323 ! lytic vacuole + +[Term] +id: GO:0098853 +name: endoplasmic reticulum-vacuole membrane contact site +namespace: cellular_component +def: "A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes." [GOC:dos, PMID:26283797] +synonym: "ER-vacuole membrane contact site" EXACT [] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0098854 +name: podocyte primary projection +namespace: cellular_component +def: "A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot." [PMID:24309184, PMID:25324828] +synonym: "glomerular visceral epithelial cell primary projection" EXACT [] +synonym: "podocyte major process" EXACT [] +synonym: "primary podocyte process" EXACT [] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0098855 +name: HCN channel complex +namespace: cellular_component +alt_id: GO:1990746 +alt_id: GO:1990759 +def: "A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart." [PMID:20829353] +synonym: "HCN1 channel complex" NARROW [] +synonym: "HCN2 channel complex" NARROW [] +synonym: "HCN3 channel complex" NARROW [] +synonym: "HCN4 channel complex" NARROW [] +synonym: "K/Na hyperpolarization-activated channel 3 complex" NARROW [] +synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW [] +synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW [] +synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW [] +synonym: "K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT [] +synonym: "potassium/sodium hyperpolarization-activated channel 3 complex" NARROW [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex" NARROW [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex" NARROW [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer" RELATED [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex" NARROW [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer" RELATED [] +synonym: "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex" EXACT [] +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:0098856 +name: intestinal lipid absorption +namespace: biological_process +def: "Any process in which lipids are taken up from the contents of the intestine." [GOC:dos, GOC:sl, PMID:18768481] +is_a: GO:0006869 ! lipid transport +is_a: GO:0050892 ! intestinal absorption + +[Term] +id: GO:0098857 +name: membrane microdomain +namespace: cellular_component +def: "A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it." [PMID:20044567, PMID:26253820] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0098858 +name: actin-based cell projection +namespace: cellular_component +def: "A cell projection supported by an assembly of actin filaments, and which lacks microtubules." [PMID:15661519] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0098859 +name: actin filament bundle of actin-based cell projection +namespace: cellular_component +def: "A bundle of cross-linked actin filaments that is part of an actin-based cell protrusion, in which filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which stabilizes the filaments." [PMID:12566431, PMID:15661519] +is_a: GO:0097518 ! parallel actin filament bundle +relationship: part_of GO:0098858 ! actin-based cell projection + +[Term] +id: GO:0098860 +name: actin filament bundle of stereocilium +namespace: cellular_component +def: "A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane." [PMID:15661519] +is_a: GO:0098859 ! actin filament bundle of actin-based cell projection +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0098861 +name: actin filament bundle of filopodium +namespace: cellular_component +def: "A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex." [PMID:12566431] +is_a: GO:0098859 ! actin filament bundle of actin-based cell projection +relationship: part_of GO:0030175 ! filopodium + +[Term] +id: GO:0098862 +name: cluster of actin-based cell projections +namespace: cellular_component +def: "A cell part consisting of multiple, closely packed actin-based cell projections." [GOC:dos] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0098863 +name: nuclear migration by microtubule mediated pushing forces +namespace: biological_process +def: "The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules." [GOC:vw, PMID:11309419, PMID:16611238] +is_a: GO:0007097 ! nuclear migration +is_a: GO:0099098 ! microtubule polymerization based movement +is_a: GO:0099111 ! microtubule-based transport + +[Term] +id: GO:0098864 +name: modification by symbiont of host tight cell-cell junction +namespace: biological_process +def: "The process in which a symbiont organism effects a change in the structure or function of its host tight junction, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [PMID:24287273] +is_a: GO:0044067 ! modification by symbiont of host intercellular junctions + +[Term] +id: GO:0098865 +name: modification by symbiont of host bicellular tight junctions +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of its host bicellular tight junctions, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet." [PMID:24287273] +is_a: GO:0098864 ! modification by symbiont of host tight cell-cell junction + +[Term] +id: GO:0098866 +name: multivesicular body fusion to apical plasma membrane +namespace: biological_process +def: "The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell." [PMID:26459596] +is_a: GO:0099500 ! vesicle fusion to plasma membrane +relationship: part_of GO:1990182 ! exosomal secretion + +[Term] +id: GO:0098867 +name: intramembranous bone growth +namespace: biological_process +def: "The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone." [PMID:26399686] +is_a: GO:0098868 ! bone growth + +[Term] +id: GO:0098868 +name: bone growth +namespace: biological_process +def: "The increase in size or mass of a bone that contributes to the shaping of that bone." [GOC:dos] +is_a: GO:0035265 ! organ growth + +[Term] +id: GO:0098869 +name: cellular oxidant detoxification +namespace: biological_process +def: "Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide." [GOC:dos, GOC:vw] +is_a: GO:1990748 ! cellular detoxification + +[Term] +id: GO:0098870 +name: action potential propagation +namespace: biological_process +def: "The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold." [GOC:dos] +is_a: GO:0001508 ! action potential + +[Term] +id: GO:0098871 +name: postsynaptic actin cytoskeleton +namespace: cellular_component +def: "The actin cytoskeleton that is part of a postsynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0015629 ! actin cytoskeleton +is_a: GO:0099571 ! postsynaptic cytoskeleton + +[Term] +id: GO:0098872 +name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse." [GOC:dos] +subset: goslim_synapse +synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [] +synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity +is_a: GO:0099583 ! neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration + +[Term] +id: GO:0098873 +name: neuronal action potential back-propagation +namespace: biological_process +def: "Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma." [GOC:dos] +is_a: GO:0098870 ! action potential propagation + +[Term] +id: GO:0098874 +name: spike train +namespace: biological_process +alt_id: GO:0099603 +def: "A series of sequential, propagated action potentials occurring in a single cell." [ISBN:978-0071390118] +synonym: "burst of action potentials" EXACT [] +synonym: "spike-train" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0098875 +name: epididymosome +namespace: cellular_component +def: "A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins." [GOC:dos, GOC:mg, PMID:23177142, PMID:26112475] +is_a: GO:1990742 ! microvesicle + +[Term] +id: GO:0098876 +name: vesicle-mediated transport to the plasma membrane +namespace: biological_process +def: "The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis." [GOC:dos] +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0098877 +name: neurotransmitter receptor transport to plasma membrane +namespace: biological_process +def: "The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles." [GOC:dos] +subset: goslim_synapse +is_a: GO:0090150 ! establishment of protein localization to membrane +is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane +is_a: GO:0099637 ! neurotransmitter receptor transport +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0098878 +name: neurotransmitter receptor complex +namespace: cellular_component +def: "Any protein complex that is capable of functioning as a neurotransmitter receptor." [GOC:dos] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:0098879 +name: structural constituent of postsynaptic specialization +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a postsynaptic specialization." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099186 ! structural constituent of postsynapse + +[Term] +id: GO:0098880 +name: maintenance of postsynaptic specialization structure +namespace: biological_process +def: "A process which maintains the organization and the arrangement of proteins in the presynaptic specialization." [GOC:dos] +subset: goslim_synapse +is_a: GO:0097106 ! postsynaptic density organization +is_a: GO:0099558 ! maintenance of synapse structure + +[Term] +id: GO:0098881 +name: exocytic insertion of neurotransmitter receptor to plasma membrane +namespace: biological_process +def: "The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion." [GOC:aruk, GOC:bc, PMID:19503082] +subset: goslim_synapse +synonym: "neurotransmitter receptor insertion" EXACT [] +is_a: GO:0006904 ! vesicle docking involved in exocytosis +is_a: GO:0090522 ! vesicle tethering involved in exocytosis +relationship: part_of GO:0098877 ! neurotransmitter receptor transport to plasma membrane + +[Term] +id: GO:0098882 +name: structural constituent of presynaptic active zone +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a presynaptic active zone." [GOC:dos] +subset: goslim_synapse +synonym: "structural constituent of active zone" EXACT syngo_official_label [] +is_a: GO:0098918 ! structural constituent of synapse + +[Term] +id: GO:0098883 +name: synapse pruning +namespace: biological_process +def: "A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared." [GOC:dos, PMID:12062020, PMID:18083105, PMID:22632716, PMID:29844190] +subset: goslim_synapse +synonym: "synapse clearance" EXACT [GOC:aruk, GOC:bc, PMID:22632716] +synonym: "synapse disassembly" EXACT syngo_official_label [PMID:12062020] +synonym: "synapse elimination" EXACT [GOC:aruk, GOC:bc, PMID:18083105, PMID:29844190] +synonym: "synapse removal" EXACT [GOC:aruk, GOC:bc, PMID:22632716] +is_a: GO:0050808 ! synapse organization +is_a: GO:0150146 ! cell junction disassembly + +[Term] +id: GO:0098884 +name: postsynaptic neurotransmitter receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle." [GOC:dos] +subset: goslim_synapse +synonym: "postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label [] +is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels +is_a: GO:0099590 ! neurotransmitter receptor internalization +is_a: GO:0140239 ! postsynaptic endocytosis + +[Term] +id: GO:0098885 +name: modification of postsynaptic actin cytoskeleton +namespace: biological_process +def: "Any process that modifies the structure of a postsynaptic actin cytoskeleton." [GOC:dos] +comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. +subset: goslim_synapse +synonym: "postsynaptic actin cytoskeleton remodelling" EXACT [] +is_a: GO:0099010 ! modification of postsynaptic structure + +[Term] +id: GO:0098886 +name: modification of dendritic spine +namespace: biological_process +def: "Any process that modifies the structure of a dendritic spine." [GOC:dos] +comment: This class does not cover assembly or disassembly of dendritic spines, only the modification/remodelling of existing ones. +is_a: GO:0099010 ! modification of postsynaptic structure + +[Term] +id: GO:0098887 +name: neurotransmitter receptor transport, endosome to postsynaptic membrane +namespace: biological_process +def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos] +subset: goslim_synapse +synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD [] +is_a: GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane +is_a: GO:0099639 ! neurotransmitter receptor transport, endosome to plasma membrane + +[Term] +id: GO:0098888 +name: extrinsic component of presynaptic membrane +namespace: cellular_component +def: "The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +synonym: "extrinsic component of presynaptic plasma membrane" EXACT [] +is_a: GO:0099243 ! extrinsic component of synaptic membrane +relationship: part_of GO:0042734 ! presynaptic membrane + +[Term] +id: GO:0098889 +name: intrinsic component of presynaptic membrane +namespace: cellular_component +def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to presynaptic membrane" NARROW [] +is_a: GO:0099240 ! intrinsic component of synaptic membrane +relationship: part_of GO:0042734 ! presynaptic membrane + +[Term] +id: GO:0098890 +name: extrinsic component of postsynaptic membrane +namespace: cellular_component +def: "The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0099243 ! extrinsic component of synaptic membrane +relationship: part_of GO:0045211 ! postsynaptic membrane + +[Term] +id: GO:0098891 +name: extrinsic component of presynaptic active zone membrane +namespace: cellular_component +def: "The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098888 ! extrinsic component of presynaptic membrane +relationship: part_of GO:0048787 ! presynaptic active zone membrane + +[Term] +id: GO:0098892 +name: extrinsic component of postsynaptic specialization membrane +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098890 ! extrinsic component of postsynaptic membrane +relationship: part_of GO:0099634 ! postsynaptic specialization membrane + +[Term] +id: GO:0098893 +name: extrinsic component of postsynaptic endocytic zone +namespace: cellular_component +def: "The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098890 ! extrinsic component of postsynaptic membrane +relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane + +[Term] +id: GO:0098894 +name: extrinsic component of presynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098888 ! extrinsic component of presynaptic membrane +relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane + +[Term] +id: GO:0098895 +name: postsynaptic endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a postsynaptic endosome." [GOC:pz] +subset: goslim_synapse +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0098845 ! postsynaptic endosome + +[Term] +id: GO:0098896 +name: postsynaptic early endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a postsynaptic early endosome." [GOC:pz] +subset: goslim_synapse +is_a: GO:0031901 ! early endosome membrane +is_a: GO:0098895 ! postsynaptic endosome membrane +relationship: part_of GO:0098842 ! postsynaptic early endosome + +[Term] +id: GO:0098897 +name: spine apparatus membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the spine apparatus." [GOC:mah] +subset: goslim_synapse +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:0097444 ! spine apparatus + +[Term] +id: GO:0098898 +name: dense core granule lumen +namespace: cellular_component +def: "The volume enclosed by the dense core granule membrane." [GOC:dos] +synonym: "dense core vesicle lumen" EXACT [] +is_a: GO:0034774 ! secretory granule lumen +relationship: part_of GO:0031045 ! dense core granule + +[Term] +id: GO:0098899 +name: spine apparatus lumen +namespace: cellular_component +def: "The volume enclosed by the spine apparatus membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0097444 ! spine apparatus + +[Term] +id: GO:0098900 +name: regulation of action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] +comment: The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. +is_a: GO:0042391 ! regulation of membrane potential +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0001508 ! action potential + +[Term] +id: GO:0098901 +name: regulation of cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dos, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0098900 ! regulation of action potential +relationship: regulates GO:0086001 ! cardiac muscle cell action potential + +[Term] +id: GO:0098902 +name: regulation of membrane depolarization during action potential +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] +is_a: GO:0003254 ! regulation of membrane depolarization +relationship: regulates GO:0086010 ! membrane depolarization during action potential + +[Term] +id: GO:0098903 +name: regulation of membrane repolarization during action potential +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential." [GOC:dos, GOC:dph, GOC:tb, ISBN:978-0-07-139011-8] +is_a: GO:0060306 ! regulation of membrane repolarization +is_a: GO:0098900 ! regulation of action potential +relationship: regulates GO:0086011 ! membrane repolarization during action potential + +[Term] +id: GO:0098904 +name: regulation of AV node cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "regulation of atrioventricular node cardiac muscle cell action potential" EXACT [] +synonym: "regulation of AV node cardiac muscle cell action potential" EXACT [] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: regulates GO:0086016 ! AV node cell action potential + +[Term] +id: GO:0098905 +name: regulation of bundle of His cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "regulation of bundle of His cardiac muscle cell action potential" EXACT [] +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: regulates GO:0086043 ! bundle of His cell action potential + +[Term] +id: GO:0098906 +name: regulation of Purkinje myocyte action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: regulates GO:0086017 ! Purkinje myocyte action potential + +[Term] +id: GO:0098907 +name: regulation of SA node cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +synonym: "regulation of SA node cardiac muscle cell action potential" EXACT [] +synonym: "regulation of SAN cardiac muscle cell action potential" EXACT [] +synonym: "regulation of sinoatrial node cardiac muscle cell action potential" EXACT [] +synonym: "regulation of sinus node cardiac muscle cell action potential" NARROW [] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: regulates GO:0086015 ! SA node cell action potential + +[Term] +id: GO:0098908 +name: regulation of neuronal action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:dph, GOC:isa_complete, GOC:tb] +synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051969 ! regulation of transmission of nerve impulse +is_a: GO:0098900 ! regulation of action potential +relationship: regulates GO:0019228 ! neuronal action potential + +[Term] +id: GO:0098909 +name: regulation of cardiac muscle cell action potential involved in regulation of contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: part_of GO:0086004 ! regulation of cardiac muscle cell contraction + +[Term] +id: GO:0098910 +name: regulation of atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086004 ! regulation of cardiac muscle cell contraction +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +is_a: GO:1903779 ! regulation of cardiac conduction +relationship: regulates GO:0086014 ! atrial cardiac muscle cell action potential + +[Term] +id: GO:0098911 +name: regulation of ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0086004 ! regulation of cardiac muscle cell contraction +is_a: GO:0098901 ! regulation of cardiac muscle cell action potential +relationship: regulates GO:0086005 ! ventricular cardiac muscle cell action potential + +[Term] +id: GO:0098912 +name: membrane depolarization during atrial cardiac muscle cell action potential +namespace: biological_process +def: "The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +synonym: "atrial cardiac muscle cell depolarization" BROAD [GOC:dph, GOC:tb] +synonym: "atrial depolarization" RELATED [GOC:dph, GOC:tb] +synonym: "electrocardiogram PR interval" RELATED [GOC:dph, GOC:tb] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential + +[Term] +id: GO:0098913 +name: membrane depolarization during ventricular cardiac muscle cell action potential +namespace: biological_process +def: "The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] +synonym: "ventricular depolarization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0086012 ! membrane depolarization during cardiac muscle cell action potential +relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential + +[Term] +id: GO:0098914 +name: membrane repolarization during atrial cardiac muscle cell action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +synonym: "atrial repolarization" RELATED [GOC:dph, GOC:tb] +synonym: "electrocardiogram QRS complex" RELATED [GOC:dph, GOC:tb] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +is_a: GO:0099624 ! atrial cardiac muscle cell membrane repolarization +relationship: part_of GO:0086014 ! atrial cardiac muscle cell action potential + +[Term] +id: GO:0098915 +name: membrane repolarization during ventricular cardiac muscle cell action potential +namespace: biological_process +def: "The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential." [GOC:BHF, GOC:dph, GOC:mtg_cardiac_conduct_nov11, GOC:tb] +synonym: "electrocardiogram T wave" RELATED [GOC:dph, GOC:tb] +synonym: "regulation of ventricular cardiac muscle repolarization" RELATED [GOC:dph, GOC:tb] +synonym: "ventricular repolarization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0086013 ! membrane repolarization during cardiac muscle cell action potential +is_a: GO:0099625 ! ventricular cardiac muscle cell membrane repolarization +relationship: part_of GO:0086005 ! ventricular cardiac muscle cell action potential + +[Term] +id: GO:0098916 +name: anterograde trans-synaptic signaling +namespace: biological_process +def: "Cell-cell signaling from pre to post-synapse, across the synaptic cleft." [GOC:dos] +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0098917 +name: retrograde trans-synaptic signaling +namespace: biological_process +def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft." [GOC:dos] +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0098918 +name: structural constituent of synapse +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a synapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005198 ! structural molecule activity + +[Term] +id: GO:0098919 +name: structural constituent of postsynaptic density +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a postsynaptic density." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098879 ! structural constituent of postsynaptic specialization + +[Term] +id: GO:0098920 +name: retrograde trans-synaptic signaling by lipid +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098917 ! retrograde trans-synaptic signaling +is_a: GO:0099541 ! trans-synaptic signaling by lipid + +[Term] +id: GO:0098921 +name: retrograde trans-synaptic signaling by endocannabinoid +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098920 ! retrograde trans-synaptic signaling by lipid +is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid + +[Term] +id: GO:0098922 +name: extrinsic component of dense core granule membrane +namespace: cellular_component +def: "The component of the dense core granule membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0032127 ! dense core granule membrane + +[Term] +id: GO:0098923 +name: retrograde trans-synaptic signaling by soluble gas +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098917 ! retrograde trans-synaptic signaling +is_a: GO:0099543 ! trans-synaptic signaling by soluble gas + +[Term] +id: GO:0098924 +name: retrograde trans-synaptic signaling by nitric oxide +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098923 ! retrograde trans-synaptic signaling by soluble gas +is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide + +[Term] +id: GO:0098925 +name: retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission +namespace: biological_process +def: "Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0098924 ! retrograde trans-synaptic signaling by nitric oxide +is_a: GO:0099555 ! trans-synaptic signaling by nitric oxide, modulating synaptic transmission + +[Term] +id: GO:0098926 +name: postsynaptic signal transduction +namespace: biological_process +def: "Signal transduction in which the initial step occurs in a postsynapse." [GOC:dos] +comment: Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts. +subset: gocheck_do_not_manually_annotate +subset: goslim_synapse +synonym: "postsynaptic signaling pathway" EXACT syngo_official_label [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0099536 ! synaptic signaling + +[Term] +id: GO:0098927 +name: vesicle-mediated transport between endosomal compartments +namespace: biological_process +def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome." [GOC:dos, PMID:10930469] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0098928 +name: presynaptic signal transduction +namespace: biological_process +def: "Signal transduction in which the initial step occurs in a presynapse." [GOC:dos] +comment: Do not directly annotate. This term intended for grouping. Annotate to either a subclass or to some other subclass of signal transduction extended with has_start_location/occurs_in presynapse or one of its parts. Such extensions will result in automatic annotation to this term. +subset: gocheck_do_not_manually_annotate +subset: goslim_synapse +synonym: "presynaptic signaling pathway" EXACT syngo_official_label [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0098929 +name: extrinsic component of spine apparatus membrane +namespace: cellular_component +def: "The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031312 ! extrinsic component of organelle membrane +relationship: part_of GO:0098897 ! spine apparatus membrane + +[Term] +id: GO:0098930 +name: axonal transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules in axons." [ISBN:0815316194] +subset: goslim_synapse +synonym: "axon cargo transport" EXACT [] +synonym: "axoplasmic transport" EXACT [] +xref: Wikipedia:Axoplasmic_transport +is_a: GO:0008088 ! axo-dendritic transport + +[Term] +id: GO:0098931 +name: virion attachment to host cell flagellum +namespace: biological_process +def: "The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface." [GOC:dos, VZ:3949] +xref: VZ:3949 +is_a: GO:0019062 ! virion attachment to host cell + +[Term] +id: GO:0098932 +name: disruption by virus of host cell wall peptidoglycan during virus entry +namespace: biological_process +def: "A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry." [GOC:dos, VZ:3940] +synonym: "catabolism of host cell wall peptidoglycan by virus" EXACT [] +synonym: "degradation of host cell wall peptidoglycan by virus" EXACT [] +synonym: "degradation of host peptidoglycans during virus entry" EXACT [VZ:3940] +synonym: "disassembly by virus of host cell wall peptidoglycan" EXACT [] +xref: VZ:3940 +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0052009 ! disruption by symbiont of host cell wall +is_a: GO:0098994 ! disruption of host cell envelope during viral entry + +[Term] +id: GO:0098933 +name: disruption by symbiont of host cell envelope +namespace: biological_process +def: "The process by which a symbiont breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:0198547684] +is_a: GO:0052020 ! modification by symbiont of host cell wall + +[Term] +id: GO:0098934 +name: retrograde dendritic transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098935 ! dendritic transport + +[Term] +id: GO:0098935 +name: dendritic transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules in dendrites." [ISBN:0815316194] +subset: goslim_synapse +synonym: "dendrite cargo transport" EXACT [] +is_a: GO:0008088 ! axo-dendritic transport + +[Term] +id: GO:0098936 +name: intrinsic component of postsynaptic membrane +namespace: cellular_component +def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic membrane" NARROW [] +is_a: GO:0099240 ! intrinsic component of synaptic membrane +relationship: part_of GO:0045211 ! postsynaptic membrane + +[Term] +id: GO:0098937 +name: anterograde dendritic transport +namespace: biological_process +def: "The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites." [ISBN:0815316194] +subset: goslim_synapse +is_a: GO:0098935 ! dendritic transport + +[Term] +id: GO:0098938 +name: actin cytoskeleton of dendritic spine +namespace: cellular_component +def: "The actin cytoskeleton that is part of a dendritic spine." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098836 ! cytoskeleton of dendritic spine +is_a: GO:0098871 ! postsynaptic actin cytoskeleton + +[Term] +id: GO:0098939 +name: dendritic transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in nerve cell dendrites." [GOC:ai] +subset: goslim_synapse +is_a: GO:0047497 ! mitochondrion transport along microtubule +is_a: GO:0098935 ! dendritic transport + +[Term] +id: GO:0098940 +name: anterograde trans-synaptic signaling by nitric oxide +namespace: biological_process +def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098916 ! anterograde trans-synaptic signaling +is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide + +[Term] +id: GO:0098941 +name: anterograde trans-synaptic signaling by trans-synaptic protein complex +namespace: biological_process +def: "Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098916 ! anterograde trans-synaptic signaling +is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex + +[Term] +id: GO:0098942 +name: retrograde trans-synaptic signaling by trans-synaptic protein complex +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098917 ! retrograde trans-synaptic signaling +is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex + +[Term] +id: GO:0098943 +name: neurotransmitter receptor transport, postsynaptic endosome to lysosome +namespace: biological_process +def: "The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation." [GOC:dos] +subset: goslim_synapse +synonym: "postsynaptic neurotransmitter receptor endosomal trafficking" BROAD [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0008333 ! endosome to lysosome transport +is_a: GO:0061462 ! protein localization to lysosome +is_a: GO:0072666 ! establishment of protein localization to vacuole +is_a: GO:0099637 ! neurotransmitter receptor transport + +[Term] +id: GO:0098944 +name: postsynaptic recycling endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a postsynaptic recycling endosome." [GOC:pz] +subset: goslim_synapse +is_a: GO:0098895 ! postsynaptic endosome membrane +relationship: part_of GO:0098837 ! postsynaptic recycling endosome + +[Term] +id: GO:0098945 +name: intrinsic component of presynaptic active zone membrane +namespace: cellular_component +def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to presynaptic acive zone membrane" NARROW [] +is_a: GO:0098889 ! intrinsic component of presynaptic membrane +relationship: part_of GO:0048787 ! presynaptic active zone membrane + +[Term] +id: GO:0098946 +name: intrinsic component of presynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to presynaptic acive zone membrane" NARROW [] +is_a: GO:0098889 ! intrinsic component of presynaptic membrane +relationship: part_of GO:0098835 ! presynaptic endocytic zone membrane + +[Term] +id: GO:0098947 +name: intrinsic component of postsynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic acive zone membrane" NARROW [] +is_a: GO:0098936 ! intrinsic component of postsynaptic membrane +relationship: part_of GO:0098844 ! postsynaptic endocytic zone membrane + +[Term] +id: GO:0098948 +name: intrinsic component of postsynaptic specialization membrane +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic specialization membrane" NARROW [] +is_a: GO:0098936 ! intrinsic component of postsynaptic membrane +relationship: part_of GO:0099634 ! postsynaptic specialization membrane + +[Term] +id: GO:0098949 +name: intrinsic component of postsynaptic endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic endosome membrane" NARROW [] +is_a: GO:0031302 ! intrinsic component of endosome membrane +relationship: part_of GO:0098895 ! postsynaptic endosome membrane + +[Term] +id: GO:0098950 +name: intrinsic component of postsynaptic early endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic early endosome membrane" NARROW [] +is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane +relationship: part_of GO:0098896 ! postsynaptic early endosome membrane + +[Term] +id: GO:0098951 +name: intrinsic component of postsynaptic recycling endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic recycling endosome membrane" EXACT [] +is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane +relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane + +[Term] +id: GO:0098952 +name: intrinsic component of spine apparatus membrane +namespace: cellular_component +def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to spine apparatus membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0098897 ! spine apparatus membrane + +[Term] +id: GO:0098953 +name: receptor diffusion trapping +namespace: biological_process +def: "The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix." [PMID:18832033] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0098954 +name: presynaptic endosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a presynaptic endosome." [GOC:pz] +subset: goslim_synapse +is_a: GO:0010008 ! endosome membrane +relationship: part_of GO:0098830 ! presynaptic endosome + +[Term] +id: GO:0098955 +name: intrinsic component of presynaptic endosome membrane +namespace: cellular_component +def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to presynaptic endosome membrane" EXACT [] +is_a: GO:0031302 ! intrinsic component of endosome membrane +relationship: part_of GO:0098954 ! presynaptic endosome membrane + +[Term] +id: GO:0098956 +name: intrinsic component of dense core granule membrane +namespace: cellular_component +def: "The component of the dense core granule membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +synonym: "intrinsic to dense core granule membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0032127 ! dense core granule membrane + +[Term] +id: GO:0098957 +name: anterograde axonal transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse." [GOC:dos] +subset: goslim_synapse +synonym: "anterograde axon transport of mitochondria" EXACT [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0019896 ! axonal transport of mitochondrion + +[Term] +id: GO:0098958 +name: retrograde axonal transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse." [GOC:dos] +subset: goslim_synapse +synonym: "retrograde axon transport of mitochondria" EXACT [] +is_a: GO:0008090 ! retrograde axonal transport +is_a: GO:0019896 ! axonal transport of mitochondrion + +[Term] +id: GO:0098959 +name: retrograde dendritic transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse." [GOC:dos] +subset: goslim_synapse +synonym: "retrograde dendrite transport of mitochondria" EXACT [] +is_a: GO:0098939 ! dendritic transport of mitochondrion + +[Term] +id: GO:0098960 +name: postsynaptic neurotransmitter receptor activity +namespace: molecular_function +def: "Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission." [GOC:dos, GOC:signaling] +synonym: "neurotransmitter receptor activity involved in chemical synaptic transmission" EXACT [] +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0098961 +name: dendritic transport of ribonucleoprotein complex +namespace: biological_process +def: "The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] +subset: goslim_synapse +synonym: "dendritic transport of RNP complex" EXACT [] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0098935 ! dendritic transport + +[Term] +id: GO:0098962 +name: regulation of postsynaptic neurotransmitter receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031644 ! regulation of nervous system process +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0099601 ! regulation of neurotransmitter receptor activity + +[Term] +id: GO:0098963 +name: dendritic transport of messenger ribonucleoprotein complex +namespace: biological_process +def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites." [GOC:dos] +subset: goslim_synapse +synonym: "dendritic transport of mRNA RNP complex" EXACT [] +is_a: GO:0098961 ! dendritic transport of ribonucleoprotein complex + +[Term] +id: GO:0098964 +name: anterograde dendritic transport of messenger ribonucleoprotein complex +namespace: biological_process +def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] +subset: goslim_synapse +synonym: "anterograde dendritic transport of mRNA RNP complex" EXACT [] +is_a: GO:0098937 ! anterograde dendritic transport +is_a: GO:0098963 ! dendritic transport of messenger ribonucleoprotein complex + +[Term] +id: GO:0098965 +name: extracellular matrix of synaptic cleft +namespace: cellular_component +def: "The portion of the extracellular matrix that lies within the synaptic cleft." [GOC:dos] +subset: goslim_synapse +synonym: "ECM of synaptic cleft" EXACT [] +synonym: "synaptic cleft ECM" EXACT [] +is_a: GO:0062023 ! collagen-containing extracellular matrix +relationship: part_of GO:0099535 ! synapse-associated extracellular matrix + +[Term] +id: GO:0098966 +name: perisynaptic extracellular matrix +namespace: cellular_component +def: "The portion of the extracellular matrix that lies within the perisynaptic space." [GOC:dos] +subset: goslim_synapse +synonym: "extrasynaptic extracellular matrix" EXACT [] +synonym: "perisynaptic ECM" EXACT [] +is_a: GO:0062023 ! collagen-containing extracellular matrix +relationship: part_of GO:0099535 ! synapse-associated extracellular matrix + +[Term] +id: GO:0098967 +name: exocytic insertion of neurotransmitter receptor to postsynaptic membrane +namespace: biological_process +def: "The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion." [PMID:19503082] +subset: goslim_synapse +is_a: GO:0006887 ! exocytosis +is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels +relationship: part_of GO:0098969 ! neurotransmitter receptor transport to postsynaptic membrane + +[Term] +id: GO:0098968 +name: neurotransmitter receptor transport postsynaptic membrane to endosome +namespace: biological_process +def: "Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome." [GOC:dos] +subset: goslim_synapse +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0062237 ! protein localization to postsynapse +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0099637 ! neurotransmitter receptor transport +is_a: GO:1902946 ! protein localization to early endosome + +[Term] +id: GO:0098969 +name: neurotransmitter receptor transport to postsynaptic membrane +namespace: biological_process +def: "The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles." [GOC:dos] +subset: goslim_synapse +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane +is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels +is_a: GO:1903540 ! establishment of protein localization to postsynaptic membrane + +[Term] +id: GO:0098970 +name: postsynaptic neurotransmitter receptor diffusion trapping +namespace: biological_process +def: "The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization." [PMID:18832033] +subset: goslim_synapse +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels +is_a: GO:0099628 ! neurotransmitter receptor diffusion trapping + +[Term] +id: GO:0098971 +name: anterograde dendritic transport of neurotransmitter receptor complex +namespace: biological_process +def: "The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0098937 ! anterograde dendritic transport + +[Term] +id: GO:0098972 +name: anterograde dendritic transport of mitochondrion +namespace: biological_process +def: "The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098937 ! anterograde dendritic transport +is_a: GO:0098939 ! dendritic transport of mitochondrion + +[Term] +id: GO:0098973 +name: structural constituent of postsynaptic actin cytoskeleton +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005200 ! structural constituent of cytoskeleton +is_a: GO:0099186 ! structural constituent of postsynapse + +[Term] +id: GO:0098974 +name: postsynaptic actin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0099188 ! postsynaptic cytoskeleton organization + +[Term] +id: GO:0098975 +name: postsynapse of neuromuscular junction +namespace: cellular_component +def: "The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma." [GOC:dos, Wikipedia:Neuromuscular_junction&oldid=723623502] +is_a: GO:0098794 ! postsynapse +relationship: part_of GO:0031594 ! neuromuscular junction + +[Term] +id: GO:0098976 +name: excitatory chemical synaptic transmission +namespace: biological_process +def: "Synaptic transmission that results in an excitatory postsynaptic potential." [GOC:dos] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0098977 +name: inhibitory chemical synaptic transmission +namespace: biological_process +def: "Synaptic transmission that results in an inhibitory postsynaptic potential." [GOC:dos] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0098978 +name: glutamatergic synapse +namespace: cellular_component +def: "A synapse that uses glutamate as a neurotransmitter." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098979 +name: polyadic synapse +namespace: cellular_component +def: "A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems." [PMID:26780543] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098980 +name: presynaptic density +namespace: cellular_component +def: "An electron dense specialization of the presynaptic active zone cytoskeleton." [GOC:dos, PMID:26780543] +is_a: GO:0048788 ! cytoskeleton of presynaptic active zone + +[Term] +id: GO:0098981 +name: cholinergic synapse +namespace: cellular_component +def: "A synapse that uses acetylcholine as a neurotransmitter." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098982 +name: GABA-ergic synapse +namespace: cellular_component +def: "A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098983 +name: symmetric, GABA-ergic, inhibitory synapse +namespace: cellular_component +def: "A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials." [GOC:dos] +is_a: GO:0032280 ! symmetric synapse +is_a: GO:0060077 ! inhibitory synapse +is_a: GO:0098982 ! GABA-ergic synapse + +[Term] +id: GO:0098984 +name: neuron to neuron synapse +namespace: cellular_component +def: "A synapse in which pre and post-synaptic cells are neurons." [GOC:dos] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0098985 +name: asymmetric, glutamatergic, excitatory synapse +namespace: cellular_component +def: "A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials." [GOC:dos] +is_a: GO:0032279 ! asymmetric synapse +is_a: GO:0060076 ! excitatory synapse +is_a: GO:0098978 ! glutamatergic synapse + +[Term] +id: GO:0098986 +name: T-bar +namespace: cellular_component +def: "A T-shaped presynpatic density. These are common in arhropod central nervous systems." [GOC:dos, PMID:26780543] +is_a: GO:0098980 ! presynaptic density + +[Term] +id: GO:0098987 +name: regulation of modification of synapse structure, modulating synaptic transmission +namespace: biological_process +def: "Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:1905244 ! regulation of modification of synaptic structure + +[Term] +id: GO:0098988 +name: G protein-coupled glutamate receptor activity +namespace: molecular_function +def: "Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [GOC:dos] +synonym: "G-protein coupled glutamate receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0008066 ! glutamate receptor activity + +[Term] +id: GO:0098989 +name: NMDA selective glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005] +is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway + +[Term] +id: GO:0098990 +name: AMPA selective glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:dos, ISBN:9780071120005] +subset: goslim_synapse +is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway + +[Term] +id: GO:0098991 +name: kainate selective glutamate receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:9780071120005] +subset: goslim_synapse +is_a: GO:0035235 ! ionotropic glutamate receptor signaling pathway + +[Term] +id: GO:0098992 +name: neuronal dense core vesicle +namespace: cellular_component +def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] +subset: goslim_synapse +is_a: GO:0031045 ! dense core granule + +[Term] +id: GO:0098993 +name: anchored component of synaptic vesicle membrane +namespace: cellular_component +def: "The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane + +[Term] +id: GO:0098994 +name: disruption of host cell envelope during viral entry +namespace: biological_process +def: "The disruption of host cell envelope by viral proteins during virus entry." [GOC:dos] +xref: VZ:3938 +is_a: GO:0098933 ! disruption by symbiont of host cell envelope +relationship: part_of GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0098995 +name: disruption by virus of host envelope lipopolysaccharide during virus entry +namespace: biological_process +def: "The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides." [GOC:dos, VZ:3940] +synonym: "degradation of host cell envelope lipopolysaccharide during viral entry" EXACT [] +synonym: "degradation of host lipopolysaccharide during virus entry" EXACT [VZ:3940] +synonym: "disassembly by virus of outer membrane lipopolysaccharide during viral entry" NARROW [] +xref: VZ:3939 +is_a: GO:0019048 ! modulation by virus of host process +is_a: GO:0052009 ! disruption by symbiont of host cell wall +is_a: GO:0098994 ! disruption of host cell envelope during viral entry + +[Term] +id: GO:0098996 +name: disruption of host cell glycocalyx during viral entry +namespace: biological_process +def: "The disruption of host cell glycocalyx by viral proteins during virus entry." [GOC:dos] +synonym: "catabolism of host glycocalyx during viral entry" EXACT [] +synonym: "degradation of host capsule during virus entry" EXACT [VZ:3896] +synonym: "degradation of host glycocalyx during viral entry" EXACT [] +synonym: "disassembly of glycocalyx during viral entry" EXACT [] +xref: VZ:3938 +is_a: GO:0098994 ! disruption of host cell envelope during viral entry + +[Term] +id: GO:0098997 +name: fusion of virus membrane with host outer membrane +namespace: biological_process +def: "Fusion of a viral membrane with the host cell outer membrane during viral entry." [GOC:dos, VZ:3941] +synonym: "fusion of viral membrane with host outer membrane" RELATED [GOC:dos, VZ:3941] +synonym: "viral envelope fusion" BROAD [] +synonym: "viral envelope fusion with host outer membrane" EXACT [] +synonym: "viral penetration via membrane fusion" BROAD [] +synonym: "viral-cell fusion molecule activity" RELATED [] +xref: VZ:3941 "Fusion of virus membrane with host cell membrane" +is_a: GO:0019064 ! fusion of virus membrane with host plasma membrane + +[Term] +id: GO:0098998 +name: extrinsic component of postsynaptic early endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane +relationship: part_of GO:0098896 ! postsynaptic early endosome membrane + +[Term] +id: GO:0098999 +name: extrinsic component of postsynaptic endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0031313 ! extrinsic component of endosome membrane +relationship: part_of GO:0098895 ! postsynaptic endosome membrane + +[Term] +id: GO:0099000 +name: viral genome ejection through host cell envelope, contractile tail mechanism +namespace: biological_process +def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope." [GOC:dos, PMID:26283379, VZ:3950] +synonym: "viral contractile tail ejection system" EXACT [VZ:3950] +xref: VZ:3950 +is_a: GO:0039678 ! viral genome ejection through host cell envelope + +[Term] +id: GO:0099001 +name: viral genome ejection through host cell envelope, long flexible tail mechanism +namespace: biological_process +def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm." [GOC:dos, PMID:22297512, VZ:3952] +synonym: "viral long flexible tail ejection system" EXACT [VZ:3952] +xref: VZ:3952 +is_a: GO:0039678 ! viral genome ejection through host cell envelope +is_a: GO:0046794 ! transport of virus + +[Term] +id: GO:0099002 +name: viral genome ejection through host cell envelope, short tail mechanism +namespace: biological_process +def: "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties." [GOC:dos, PMID:22297513, VZ:3954] +synonym: "viral short tail ejection system" EXACT [VZ:3954] +xref: VZ:3954 +is_a: GO:0039678 ! viral genome ejection through host cell envelope +is_a: GO:0046794 ! transport of virus + +[Term] +id: GO:0099003 +name: vesicle-mediated transport in synapse +namespace: biological_process +def: "Any vesicle-mediated transport that occurs in a synapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0099004 +name: calmodulin dependent kinase signaling pathway +namespace: biological_process +def: "Any signal transduction pathway involving calmodulin dependent kinase activity." [GOC:dos] +synonym: "CAMK signaling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0099005 +name: extrinsic component of postsynaptic recycling endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098999 ! extrinsic component of postsynaptic endosome membrane +relationship: part_of GO:0098944 ! postsynaptic recycling endosome membrane + +[Term] +id: GO:0099006 +name: viral entry via permeabilization of endosomal membrane +namespace: biological_process +def: "The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen." [PMID:15329727, PMID:25055856, VZ:985] +synonym: "viral penetration via permeabilization of host membrane" BROAD [vz:985] +xref: VZ:985 +is_a: GO:0140267 ! viral entry via permeabilization of host membrane + +[Term] +id: GO:0099007 +name: extrinsic component of presynaptic endosome membrane +namespace: cellular_component +def: "The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0031313 ! extrinsic component of endosome membrane +relationship: part_of GO:0098954 ! presynaptic endosome membrane + +[Term] +id: GO:0099008 +name: viral entry via permeabilization of inner membrane +namespace: biological_process +def: "The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane." [PMID:15795287, PMID:20427561, VZ:985] +synonym: "viral penetration via permeabilization of host membrane" BROAD [vz:985] +xref: VZ:985 +is_a: GO:0140267 ! viral entry via permeabilization of host membrane + +[Term] +id: GO:0099009 +name: viral genome circularization +namespace: biological_process +def: "The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities." [PMID:11894948, PMID:15489417, PMID:19523475, PMID:319596, VZ:3968] +xref: VZ:3968 +is_a: GO:0016032 ! viral process + +[Term] +id: GO:0099010 +name: modification of postsynaptic structure +namespace: biological_process +def: "Any process that modifies the structure of a postsynapse." [GOC:dos] +comment: This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones. +subset: goslim_synapse +synonym: "synapse remodelling" BROAD [] +is_a: GO:0099563 ! modification of synaptic structure + +[Term] +id: GO:0099011 +name: neuronal dense core vesicle exocytosis +namespace: biological_process +def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a neuronal dense core vesicle by fusion of the granule with the plasma membrane of a neuron in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] +is_a: GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:0099012 +name: neuronal dense core vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] +subset: goslim_synapse +is_a: GO:0032127 ! dense core granule membrane +relationship: part_of GO:0098992 ! neuronal dense core vesicle + +[Term] +id: GO:0099013 +name: neuronal dense core vesicle lumen +namespace: cellular_component +def: "The volume enclosed by a neuronal dense core vesicle membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098898 ! dense core granule lumen +relationship: part_of GO:0098992 ! neuronal dense core vesicle + +[Term] +id: GO:0099014 +name: neuronal dense core vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] +is_a: GO:0061109 ! dense core granule organization + +[Term] +id: GO:0099015 +name: degradation of host chromosome by virus +namespace: biological_process +def: "The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis." [PMID:163355, PMID:335083, PMID:3972821, PMID:5263754, VZ:3947] +xref: VZ:3947 +is_a: GO:0039637 ! catabolism by virus of host DNA + +[Term] +id: GO:0099016 +name: DNA end degradation evasion by virus +namespace: biological_process +def: "A process by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases." [GOC:dos] +xref: VZ:3963 +is_a: GO:0019049 ! mitigation of host defenses by virus + +[Term] +id: GO:0099017 +name: maintenance of protein localization at cell tip +namespace: biological_process +def: "Any process in which localization of a protein is maintained at the cell tip." [GOC:dos, GOC:vw, PMID:12894167] +synonym: "maintenance of protein location at cell tip" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell + +[Term] +id: GO:0099018 +name: restriction-modification system evasion by virus +namespace: biological_process +def: "Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction." [PMID:20348932, PMID:23979432, PMID:24123737, VZ:3966] +xref: VZ:3966 +is_a: GO:0019049 ! mitigation of host defenses by virus + +[Term] +id: GO:0099019 +name: maintenance of protein localization at growing cell tip +namespace: biological_process +def: "Any process in which localization of a protein is maintained at the growing cell tip." [GOC:dos, GOC:vw, PMID:24146635] +synonym: "maintenance of protein location at growing cell tip" EXACT [] +is_a: GO:0099017 ! maintenance of protein localization at cell tip + +[Term] +id: GO:0099020 +name: perinuclear endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the perinuclear endoplasmic reticulum." [GOC:dos, GOC:vw] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum + +[Term] +id: GO:0099021 +name: cortical endoplasmic reticulum lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of the cortical endoplasmic reticulum." [GOC:dos, GOC:vw] +is_a: GO:0005788 ! endoplasmic reticulum lumen +relationship: part_of GO:0032541 ! cortical endoplasmic reticulum + +[Term] +id: GO:0099022 +name: vesicle tethering +namespace: biological_process +def: "The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion." [PMID:27243008] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0006903 ! vesicle targeting + +[Term] +id: GO:0099023 +name: vesicle tethering complex +namespace: cellular_component +def: "Any protein complex that plays a role in vesicle tethering." [GOC:dos, GOC:vw, PMID:27243008] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0099024 +name: plasma membrane invagination +namespace: biological_process +def: "An infolding of the plasma membrane." [GOC:dos, GOC:vw] +is_a: GO:0010324 ! membrane invagination + +[Term] +id: GO:0099025 +name: anchored component of postsynaptic membrane +namespace: cellular_component +def: "The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098936 ! intrinsic component of postsynaptic membrane +is_a: GO:0099144 ! anchored component of synaptic membrane + +[Term] +id: GO:0099026 +name: anchored component of presynaptic membrane +namespace: cellular_component +def: "The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +synonym: "anchored component of presynaptic plasma membrane" EXACT [] +is_a: GO:0098889 ! intrinsic component of presynaptic membrane +is_a: GO:0099144 ! anchored component of synaptic membrane + +[Term] +id: GO:0099027 +name: anchored component of presynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane +is_a: GO:0099026 ! anchored component of presynaptic membrane + +[Term] +id: GO:0099028 +name: anchored component of postynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane +is_a: GO:0099025 ! anchored component of postsynaptic membrane + +[Term] +id: GO:0099029 +name: anchored component of presynaptic active zone membrane +namespace: cellular_component +def: "The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane +is_a: GO:0099026 ! anchored component of presynaptic membrane + +[Term] +id: GO:0099030 +name: anchored component of postsynaptic specialization membrane +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane +is_a: GO:0099025 ! anchored component of postsynaptic membrane + +[Term] +id: GO:0099031 +name: anchored component of postsynaptic density membrane +namespace: cellular_component +def: "The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane +is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane + +[Term] +id: GO:0099032 +name: anchored component of postsynaptic early endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane +is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane + +[Term] +id: GO:0099033 +name: anchored component of postsynaptic recycling endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane +is_a: GO:0099034 ! anchored component of postsynaptic endosome membrane + +[Term] +id: GO:0099034 +name: anchored component of postsynaptic endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane + +[Term] +id: GO:0099035 +name: anchored component of spine apparatus membrane +namespace: cellular_component +def: "The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0098952 ! intrinsic component of spine apparatus membrane + +[Term] +id: GO:0099036 +name: anchored component of neuronal dense core vesicle membrane +namespace: cellular_component +def: "The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane + +[Term] +id: GO:0099037 +name: anchored component of presynaptic endosome membrane +namespace: cellular_component +def: "The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031225 ! anchored component of membrane +is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane + +[Term] +id: GO:0099038 +name: ceramide floppase activity +namespace: molecular_function +def: "Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [GOC:BHF, GOC:dos, GOC:rl] +synonym: "ATP-dependent ceramide transporter activity" BROAD [] +synonym: "ATPase-coupled ceramide transporter activity" BROAD [] +synonym: "ceramide floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +synonym: "ceramide-translocating ATPase activity" BROAD [] +is_a: GO:0046623 ! sphingolipid floppase activity + +[Term] +id: GO:0099039 +name: sphingolipid translocation +namespace: biological_process +def: "The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl] +is_a: GO:0034204 ! lipid translocation +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:0099040 +name: ceramide translocation +namespace: biological_process +def: "The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:BHF, GOC:rl] +is_a: GO:0035627 ! ceramide transport +is_a: GO:0099039 ! sphingolipid translocation + +[Term] +id: GO:0099041 +name: vesicle tethering to Golgi +namespace: biological_process +def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008] +is_a: GO:0099022 ! vesicle tethering + +[Term] +id: GO:0099042 +name: nucleation of clathrin-coated pit +namespace: biological_process +def: "The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit." [GOC:dos, GOC:vw, PMID:21779028] +is_a: GO:0099024 ! plasma membrane invagination +relationship: part_of GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:0099043 +name: cargo loading involved in clathrin-dependent endocytosis +namespace: biological_process +def: "Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat." [GOC:dos, GOC:lb, GOC:vw, PMID:21779028] +is_a: GO:0035652 ! clathrin-coated vesicle cargo loading +relationship: part_of GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:0099044 +name: vesicle tethering to endoplasmic reticulum +namespace: biological_process +def: "The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion." [PMID:27243008] +is_a: GO:0099022 ! vesicle tethering + +[Term] +id: GO:0099045 +name: viral extrusion +namespace: biological_process +def: "The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded." [PMID:15567492, VZ:3951] +xref: VZ:3951 +is_a: GO:0046753 ! non-lytic viral release + +[Term] +id: GO:0099046 +name: clearance of foreign intracellular nucleic acids +namespace: biological_process +def: "A defense process that protects an organism from DNA or RNA from an invading organism." [GO:dos] +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0099047 +name: clearance of foreign intracellular RNA +namespace: biological_process +def: "A defense process that protects an organism from invading foreign RNA." [GO:dos] +is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids + +[Term] +id: GO:0099048 +name: CRISPR-cas system +namespace: biological_process +def: "An adaptive immune response of bacteria that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci." [PMID:23495939] +is_a: GO:0099046 ! clearance of foreign intracellular nucleic acids + +[Term] +id: GO:0099049 +name: clathrin coat assembly involved in endocytosis +namespace: biological_process +def: "The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation." [PMID:21779028] +is_a: GO:0048268 ! clathrin coat assembly +relationship: part_of GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:0099050 +name: vesicle scission +namespace: biological_process +def: "The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane." [PMID:21779028] +is_a: GO:0090148 ! membrane fission + +[Term] +id: GO:0099051 +name: vesicle scission involved in endocytosis +namespace: biological_process +def: "The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane." [PMID:21779028] +is_a: GO:0099050 ! vesicle scission +relationship: part_of GO:0006897 ! endocytosis + +[Term] +id: GO:0099052 +name: vesicle scission involved in clathrin-mediated endocytosis +namespace: biological_process +def: "The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane." [PMID:21779028] +comment: Like other vesicle scission events this involves dynamin. At least some of the dynamin recruiting factors are distinct to scission of clathrin-coated vesicles (PMID:21779028). +is_a: GO:0099051 ! vesicle scission involved in endocytosis +relationship: part_of GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:0099053 +name: activating signal cointegrator 1 complex +namespace: cellular_component +def: "A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3." [PMID:12077347] +synonym: "ASC-1 complex" EXACT [PMID:12077347] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0099054 +name: presynapse assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a presynapse." [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494] +subset: goslim_synapse +synonym: "presynapse biogenesis" EXACT [GOC:mah] +synonym: "presynaptic terminal assembly" EXACT [PMID:24449494] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0099172 ! presynapse organization +relationship: part_of GO:0007416 ! synapse assembly + +[Term] +id: GO:0099055 +name: integral component of postsynaptic membrane +namespace: cellular_component +def: "The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098936 ! intrinsic component of postsynaptic membrane +is_a: GO:0099699 ! integral component of synaptic membrane + +[Term] +id: GO:0099056 +name: integral component of presynaptic membrane +namespace: cellular_component +def: "The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +synonym: "integral component of presynaptic plasma membrane" EXACT [] +is_a: GO:0098889 ! intrinsic component of presynaptic membrane +is_a: GO:0099699 ! integral component of synaptic membrane + +[Term] +id: GO:0099057 +name: integral component of presynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098946 ! intrinsic component of presynaptic endocytic zone membrane +is_a: GO:0099056 ! integral component of presynaptic membrane + +[Term] +id: GO:0099058 +name: integral component of postsynaptic endocytic zone membrane +namespace: cellular_component +def: "The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098947 ! intrinsic component of postsynaptic endocytic zone membrane +is_a: GO:0099055 ! integral component of postsynaptic membrane + +[Term] +id: GO:0099059 +name: integral component of presynaptic active zone membrane +namespace: cellular_component +def: "The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098945 ! intrinsic component of presynaptic active zone membrane +is_a: GO:0099056 ! integral component of presynaptic membrane + +[Term] +id: GO:0099060 +name: integral component of postsynaptic specialization membrane +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane +is_a: GO:0099055 ! integral component of postsynaptic membrane + +[Term] +id: GO:0099061 +name: integral component of postsynaptic density membrane +namespace: cellular_component +def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099060 ! integral component of postsynaptic specialization membrane +is_a: GO:0099146 ! intrinsic component of postsynaptic density membrane + +[Term] +id: GO:0099062 +name: integral component of postsynaptic early endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098950 ! intrinsic component of postsynaptic early endosome membrane +is_a: GO:0099064 ! integral component of postsynaptic endosome membrane + +[Term] +id: GO:0099063 +name: integral component of postsynaptic recycling endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098951 ! intrinsic component of postsynaptic recycling endosome membrane +is_a: GO:0099064 ! integral component of postsynaptic endosome membrane + +[Term] +id: GO:0099064 +name: integral component of postsynaptic endosome membrane +namespace: cellular_component +def: "The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031303 ! integral component of endosome membrane +is_a: GO:0098949 ! intrinsic component of postsynaptic endosome membrane + +[Term] +id: GO:0099065 +name: integral component of spine apparatus membrane +namespace: cellular_component +def: "The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0098952 ! intrinsic component of spine apparatus membrane + +[Term] +id: GO:0099066 +name: integral component of neuronal dense core vesicle membrane +namespace: cellular_component +def: "The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:0098675 ! intrinsic component of neuronal dense core vesicle membrane + +[Term] +id: GO:0099067 +name: integral component of presynaptic endosome membrane +namespace: cellular_component +def: "The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0031303 ! integral component of endosome membrane +is_a: GO:0098955 ! intrinsic component of presynaptic endosome membrane + +[Term] +id: GO:0099068 +name: postsynapse assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:bf, GOC:dos, GOCL:PARL] +synonym: "postsynapse biogenesis" EXACT [GOC:mah] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0099173 ! postsynapse organization +relationship: part_of GO:0007416 ! synapse assembly + +[Term] +id: GO:0099069 +name: synaptic vesicle tethering involved in synaptic vesicle exocytosis +namespace: biological_process +def: "The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion." [GOC:rn] +is_a: GO:0090522 ! vesicle tethering involved in exocytosis +relationship: part_of GO:0016081 ! synaptic vesicle docking + +[Term] +id: GO:0099070 +name: static microtubule bundle +namespace: cellular_component +def: "A microtubule bundle that has a constant length, and in which microtubule sliding does not take place." [GOC:vw, PMID:26124291] +comment: In fission yeast, quiescent cells contain only static microtubule bundles. +synonym: "Q-MT bundle" NARROW [] +synonym: "quiescent cell microtubule bundle" NARROW [] +synonym: "quiescent cell MT bundle" NARROW [] +is_a: GO:0097427 ! microtubule bundle + +[Term] +id: GO:0099071 +name: dynamic microtubule bundle +namespace: cellular_component +def: "A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place." [GOC:vw, PMID:26124291] +is_a: GO:0097427 ! microtubule bundle + +[Term] +id: GO:0099072 +name: regulation of postsynaptic membrane neurotransmitter receptor levels +namespace: biological_process +def: "Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0065008 ! regulation of biological quality + +[Term] +id: GO:0099073 +name: mitochondrion-derived vesicle +namespace: cellular_component +def: "A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:18207745, PMID:20619655, PMID:22226745, PMID:23300790] +synonym: "MDV" EXACT [PMID:26618722] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0099074 +name: mitochondrion to lysosome transport +namespace: biological_process +def: "Transport from the mitochondrion to the lysosome, mediated by mitochondrion-derived vesicles." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] +is_a: GO:0006839 ! mitochondrial transport +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport + +[Term] +id: GO:0099075 +name: mitochondrion-derived vesicle mediated transport +namespace: biological_process +def: "Transport from the mitochondrion, mediated by mitochondrion derived vesicles." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:2061965, PMID:20619655] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0099076 +name: mitochondrion to peroxisome transport +namespace: biological_process +def: "Transport from the mitochondrion to the peroxisome, mediated by mitochondrion-derived vesicles." [GOC:bc, GOC:pad, GOC:PARL-UCL, PMID:20619655] +is_a: GO:0099075 ! mitochondrion-derived vesicle mediated transport + +[Term] +id: GO:0099077 +name: histone-dependent DNA binding +namespace: molecular_function +def: "DNA-binding activity that is dependent on binding to a histone." [PMID:11691835] +is_a: GO:0003677 ! DNA binding + +[Term] +id: GO:0099078 +name: BORC complex +namespace: cellular_component +def: "A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors." [GOC:dos, GOC:li, PMID:25898167] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0099079 +name: actin body +namespace: cellular_component +def: "An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin." [PMID:16914523] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015629 ! actin cytoskeleton + +[Term] +id: GO:0099080 +name: supramolecular complex +namespace: cellular_component +def: "A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber." [GOC:dos] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0099081 +name: supramolecular polymer +namespace: cellular_component +def: "A polymeric supramolecular structure." [GOC:dos] +is_a: GO:0099080 ! supramolecular complex + +[Term] +id: GO:0099082 +name: retrograde trans-synaptic signaling by neuropeptide +namespace: biological_process +def: "Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] +subset: goslim_synapse +is_a: GO:0098917 ! retrograde trans-synaptic signaling +is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide + +[Term] +id: GO:0099083 +name: retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission +namespace: biological_process +def: "Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide." [GOC:bf, GOC:dos, GOC:PARL, PMID:19448629] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide +is_a: GO:0099551 ! trans-synaptic signaling by neuropeptide, modulating synaptic transmission + +[Term] +id: GO:0099084 +name: postsynaptic specialization organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane." [GOC:BHF, GOC:sjp, PMID:21525273, PMID:26834556] +subset: goslim_synapse +synonym: "post synaptic specialization organization" EXACT [] +synonym: "post-synaptic specialization organization" EXACT [] +synonym: "postsynaptic specialization organisation" EXACT [] +is_a: GO:0006996 ! organelle organization +relationship: part_of GO:0099173 ! postsynapse organization + +[Term] +id: GO:0099085 +name: DIF dechlorinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-." [PMID:1521542, PMID:22035794] +synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity" EXACT [] +synonym: "1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity" EXACT [] +synonym: "DIF-1 3(5)-dechlorinase activity" EXACT [] +synonym: "DIF-1 dechlorinase activity" EXACT [] +synonym: "differentiation-inducing factor 1 dechlorinase activity" EXACT [] +synonym: "differentiation-inducing factor dechlorinase activity" EXACT [] +is_a: GO:0016848 ! carbon-halide lyase activity + +[Term] +id: GO:0099086 +name: synaptonemal structure +namespace: cellular_component +def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh, GOC:vw] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0099087 +name: anterograde axonal transport of messenger ribonucleoprotein complex +namespace: biological_process +def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse." [GOC:dos, PMID:26586091] +subset: goslim_synapse +synonym: "anterograde axonal transport of mRNA RNP complex" EXACT [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0099088 ! axonal transport of messenger ribonucleoprotein complex + +[Term] +id: GO:0099088 +name: axonal transport of messenger ribonucleoprotein complex +namespace: biological_process +def: "The directed movement of a messenger ribonucleoprotein complex along microtubules in axons." [GOC:dos, PMID:26586091] +subset: goslim_synapse +synonym: "axonal transport of mRNA RNP complex" EXACT [] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0098930 ! axonal transport + +[Term] +id: GO:0099089 +name: establishment of endoplasmic reticulum localization to postsynapse +namespace: biological_process +def: "The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine." [GOC:dos, PMID:21151132] +subset: goslim_synapse +synonym: "establishment of ER localization to postsynapse" EXACT [GOC:dos] +is_a: GO:0051686 ! establishment of ER localization + +[Term] +id: GO:0099091 +name: postsynaptic specialization, intracellular component +namespace: cellular_component +def: "A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] +subset: goslim_synapse +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0099572 ! postsynaptic specialization + +[Term] +id: GO:0099092 +name: postsynaptic density, intracellular component +namespace: cellular_component +def: "A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099091 ! postsynaptic specialization, intracellular component +relationship: part_of GO:0014069 ! postsynaptic density + +[Term] +id: GO:0099093 +name: calcium export from the mitochondrion +namespace: biological_process +def: "A process in which a calcium ion (Ca2+) is transported out of the mitochondrial matrix, and into the cytosol." [GOC:dos, GOC:vw] +synonym: "calcium ion transmembrane export from mitochondrion" EXACT [] +synonym: "mitochondrial calcium ion export" BROAD [GOC:vw] +synonym: "mitochondrial calcium release" EXACT [] +is_a: GO:0006851 ! mitochondrial calcium ion transmembrane transport +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:1901660 ! calcium ion export + +[Term] +id: GO:0099094 +name: ligand-gated cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0099095 +name: ligand-gated anion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +is_a: GO:0005253 ! anion channel activity +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0099096 +name: vestibular calyx terminal +namespace: cellular_component +def: "The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell." [PMID:10706428, PMID:25355208] +is_a: GO:0043679 ! axon terminus + +[Term] +id: GO:0099098 +name: microtubule polymerization based movement +namespace: biological_process +def: "The movement of a cellular component as a result of microtubule polymerization." [GOC:cjm, ISBN:0815316194] +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0099099 +name: G-protein gated ion channel activity +namespace: molecular_function +def: "An ion channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos] +is_a: GO:0015075 ! ion transmembrane transporter activity +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:0099100 +name: G-protein gated cation channel activity +namespace: molecular_function +def: "A cation channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0099099 ! G-protein gated ion channel activity + +[Term] +id: GO:0099101 +name: G-protein gated potassium channel activity +namespace: molecular_function +def: "A potassium channel activity that is gated by binding of a G-protein beta-gamma dimer." [GOC:dos, PMID:9429760] +is_a: GO:0005267 ! potassium channel activity +is_a: GO:0099100 ! G-protein gated cation channel activity + +[Term] +id: GO:0099102 +name: G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential." [GOC:dos, PMID:9429760] +subset: goslim_synapse +is_a: GO:0099101 ! G-protein gated potassium channel activity + +[Term] +id: GO:0099103 +name: channel activator activity +namespace: molecular_function +def: "Direct interaction with a channel (binding or modification), resulting in its opening. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos] +synonym: "channel gating activity" EXACT [] +is_a: GO:0016247 ! channel regulator activity +is_a: GO:0140677 ! molecular function activator activity + +[Term] +id: GO:0099104 +name: potassium channel activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a potassium channel, resulting in its opening." [GOC:dos] +is_a: GO:0015459 ! potassium channel regulator activity +is_a: GO:0099103 ! channel activator activity + +[Term] +id: GO:0099105 +name: ion channel modulating, G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of an ion channel." [GOC:dos] +synonym: "ion channel modulating, G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway + +[Term] +id: GO:0099106 +name: ion channel regulator activity +namespace: molecular_function +def: "Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:dos] +is_a: GO:0016247 ! channel regulator activity + +[Term] +id: GO:0099107 +name: ion channel regulator activity involved in G protein-coupled receptor signaling pathway +namespace: molecular_function +def: "Modulation of the activity of an ion channel via direct interaction with it as part of G protein-coupled receptor signaling." [GOC:dos] +synonym: "ion channel regulator activity involved in G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0099106 ! ion channel regulator activity + +[Term] +id: GO:0099108 +name: potassium channel activator activity involved in G protein-coupled receptor signaling pathway +namespace: molecular_function +def: "Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling." [PMID:9429760] +comment: Examples include G-protein beta-gamma complexes that bind to and activate potassium channels. +subset: goslim_synapse +synonym: "potassium channel activator activity involved in G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0099104 ! potassium channel activator activity +is_a: GO:0099107 ! ion channel regulator activity involved in G protein-coupled receptor signaling pathway + +[Term] +id: GO:0099109 +name: potassium channel activating, G protein-coupled receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel." [GOC:dos, PMID:9429760] +synonym: "potassium channel activating, G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0099105 ! ion channel modulating, G protein-coupled receptor signaling pathway + +[Term] +id: GO:0099110 +name: microtubule polymerization based protein transport to cell tip cortex +namespace: biological_process +def: "The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached." [GOC:dos, GOC:vw, PMID:11018050] +is_a: GO:0099112 ! microtubule polymerization based protein transport +is_a: GO:1990896 ! protein localization to cell cortex of cell tip + +[Term] +id: GO:0099111 +name: microtubule-based transport +namespace: biological_process +def: "A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] +is_a: GO:0006810 ! transport +is_a: GO:0007018 ! microtubule-based movement + +[Term] +id: GO:0099112 +name: microtubule polymerization based protein transport +namespace: biological_process +def: "The transport of a protein driven by polymerization of a microtubule to which it is attached." [GOC:dos, GOC:vw, PMID:11018050] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0099098 ! microtubule polymerization based movement +is_a: GO:0099118 ! microtubule-based protein transport + +[Term] +id: GO:0099113 +name: negative regulation of presynaptic cytosolic calcium concentration +namespace: biological_process +def: "Any process that decreases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0051481 ! negative regulation of cytosolic calcium ion concentration +is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration + +[Term] +id: GO:0099115 +name: chromosome, subtelomeric region +namespace: cellular_component +alt_id: GO:1990421 +alt_id: GO:1990707 +def: "A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin." [GOC:mah, PMID:18761674, PMID:22771823, PMID:26205977, PMID:7660126] +synonym: "nuclear subtelomeric heterochromatin" NARROW [] +synonym: "sub-telomeric heterochromatin" RELATED [] +synonym: "subtelomere" EXACT [] +synonym: "subtelomeric heterochromatin" RELATED [] +xref: SO:0001997 +is_a: GO:0000781 ! chromosome, telomeric region + +[Term] +id: GO:0099116 +name: tRNA 5'-end processing +namespace: biological_process +def: "The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:dos, GOC:pf, PMID:27484477] +synonym: "tRNA 5' processing" EXACT [] +is_a: GO:0008033 ! tRNA processing +is_a: GO:0034471 ! ncRNA 5'-end processing + +[Term] +id: GO:0099117 +name: protein transport along microtubule to cell tip +namespace: biological_process +def: "The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins." [PMID:15177031] +is_a: GO:0098840 ! protein transport along microtubule +is_a: GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:0099118 +name: microtubule-based protein transport +namespace: biological_process +def: "A microtubule-based process that results in the transport of proteins." [GOC:vw] +is_a: GO:0015031 ! protein transport +is_a: GO:0099111 ! microtubule-based transport + +[Term] +id: GO:0099119 +name: 3-demethylubiquinol-8 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8." [GOC:ic] +is_a: GO:0061542 ! 3-demethylubiquinol-n 3-O-methyltransferase activity + +[Term] +id: GO:0099120 +name: socially cooperative development +namespace: biological_process +alt_id: GO:0090702 +def: "The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies." [GOC:pf, PMID:12448714] +synonym: "colonial development" EXACT [] +synonym: "non-reproductive fruiting body development" RELATED [] +synonym: "socially co-operative development" EXACT [] +is_a: GO:0048856 ! anatomical structure development +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms + +[Term] +id: GO:0099121 +name: fungal sorus development +namespace: biological_process +def: "The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure." [GOC:dos] +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:0099122 +name: RNA polymerase II C-terminal domain binding +namespace: molecular_function +def: "Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." [PMID:20889714] +synonym: "RNAP II C-terminal binding" EXACT [] +is_a: GO:0000993 ! RNA polymerase II complex binding + +[Term] +id: GO:0099123 +name: somato-dendritic dopamine secretion +namespace: biological_process +def: "The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron." [GOC:bf, GOC:PARL, PMID:21576241] +synonym: "somatodendritic dopamine release" EXACT [PMID:21576241] +synonym: "STD DA release" EXACT [PMID:21576241] +synonym: "STD dopamine release" EXACT [PMID:21576241] +is_a: GO:0014046 ! dopamine secretion +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0099124 +name: axonal dopamine secretion +namespace: biological_process +def: "The regulated release of dopamine from an axon." [GOC:bf, GOC:PARL, PMID:21576241] +synonym: "axonal DA release" EXACT [PMID:21576241] +synonym: "axonal dopamine release" EXACT [PMID:21576241] +is_a: GO:0014046 ! dopamine secretion +is_a: GO:0051649 ! establishment of localization in cell + +[Term] +id: GO:0099125 +name: PAK family kinase-Sog2 complex +namespace: cellular_component +def: "A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network." [PMID:23462181] +is_a: GO:1902911 ! protein kinase complex + +[Term] +id: GO:0099126 +name: transforming growth factor beta complex +namespace: cellular_component +def: "A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP." [GOC:bhm, PMID:22943793] +synonym: "TGF-beta complex" EXACT [] +synonym: "TGF-beta dimer" EXACT [] +synonym: "TGFB complex" EXACT [] +synonym: "TGFB dimer" EXACT [] +synonym: "TGFbeta complex" EXACT [] +synonym: "TGFbeta dimer" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0099127 +name: envenomation resulting in positive regulation of argininosuccinate synthase activity in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism." [PMID:19491403] +synonym: "envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0099128 +name: mitochondrial iron-sulfur cluster assembly complex +namespace: cellular_component +def: "A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine." [PMID:27519411] +is_a: GO:0098798 ! mitochondrial protein-containing complex + +[Term] +id: GO:0099129 +name: cochlear outer hair cell electromotile response +namespace: biological_process +def: "A rapid, force generating length change of an outer hair cell in response to electical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification." [PMID:12239568, PMID:2187727] +is_a: GO:0006928 ! movement of cell or subcellular component + +[Term] +id: GO:0099130 +name: estrogen binding +namespace: molecular_function +def: "Binding to an estrogen." [GOC:dos] +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:0099134 +name: chimeric sorocarp development +namespace: biological_process +def: "Development of a sorocarp formed by aggregation of cells with different genotypes." [PMID:18272966] +subset: gocheck_do_not_manually_annotate +is_a: GO:0030587 ! sorocarp development +is_a: GO:0099136 ! chimeric non-reproductive fruiting body development + +[Term] +id: GO:0099135 +name: chimeric colonial development +namespace: biological_process +def: "Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype." [PMID:18272966] +subset: gocheck_do_not_manually_annotate +is_a: GO:0099120 ! socially cooperative development + +[Term] +id: GO:0099136 +name: chimeric non-reproductive fruiting body development +namespace: biological_process +def: "Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes." [PMID:18272966] +subset: gocheck_do_not_manually_annotate +is_a: GO:0099135 ! chimeric colonial development + +[Term] +id: GO:0099137 +name: altruistic, chimeric, non-reproductive fruiting body development +namespace: biological_process +def: "Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966] +synonym: "fully co-operative, chimeric, non-reproductive fruiting body development" EXACT [] +is_a: GO:0099136 ! chimeric non-reproductive fruiting body development + +[Term] +id: GO:0099138 +name: altruistic, chimeric sorocarp development +namespace: biological_process +def: "Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell." [PMID:18272966] +synonym: "fully co-operative, chimeric sorocarp development" EXACT [] +is_a: GO:0099134 ! chimeric sorocarp development +is_a: GO:0099137 ! altruistic, chimeric, non-reproductive fruiting body development + +[Term] +id: GO:0099139 +name: cheating during chimeric sorocarp development +namespace: biological_process +def: "Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes." [PMID:18272966] +is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation +relationship: part_of GO:0099134 ! chimeric sorocarp development + +[Term] +id: GO:0099140 +name: presynaptic actin cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0030036 ! actin cytoskeleton organization +is_a: GO:0099187 ! presynaptic cytoskeleton organization + +[Term] +id: GO:0099141 +name: cellular response to protozoan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:dos] +is_a: GO:0001562 ! response to protozoan + +[Term] +id: GO:0099142 +name: intracellularly ATP-gated ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:9755289] +is_a: GO:0005217 ! intracellular ligand-gated ion channel activity +is_a: GO:0035381 ! ATP-gated ion channel activity + +[Term] +id: GO:0099143 +name: presynaptic actin cytoskeleton +namespace: cellular_component +def: "The actin cytoskeleton that is part of a presynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0015629 ! actin cytoskeleton +is_a: GO:0099569 ! presynaptic cytoskeleton + +[Term] +id: GO:0099144 +name: anchored component of synaptic membrane +namespace: cellular_component +def: "The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0046658 ! anchored component of plasma membrane +is_a: GO:0099240 ! intrinsic component of synaptic membrane + +[Term] +id: GO:0099145 +name: regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:1902683 ! regulation of receptor localization to synapse +is_a: GO:1904375 ! regulation of protein localization to cell periphery +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0098967 ! exocytic insertion of neurotransmitter receptor to postsynaptic membrane + +[Term] +id: GO:0099146 +name: intrinsic component of postsynaptic density membrane +namespace: cellular_component +def: "The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic specialization membrane" NARROW [] +is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane +relationship: part_of GO:0098839 ! postsynaptic density membrane + +[Term] +id: GO:0099147 +name: extrinsic component of postsynaptic density membrane +namespace: cellular_component +def: "The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:autophagy, GOC:mf] +subset: goslim_synapse +is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane +relationship: part_of GO:0098839 ! postsynaptic density membrane + +[Term] +id: GO:0099148 +name: regulation of synaptic vesicle docking +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle docking." [GOC:dos] +subset: goslim_synapse +is_a: GO:0106020 ! regulation of vesicle docking +relationship: regulates GO:0016081 ! synaptic vesicle docking + +[Term] +id: GO:0099149 +name: regulation of postsynaptic neurotransmitter receptor internalization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse." [GOC:ai] +subset: goslim_synapse +synonym: "regulation of postsynaptic neurotransmitter receptor endocytosis" EXACT syngo_official_label [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0098884 ! postsynaptic neurotransmitter receptor internalization + +[Term] +id: GO:0099150 +name: regulation of postsynaptic specialization assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization." [GOC:dos] +subset: goslim_synapse +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0098698 ! postsynaptic specialization assembly + +[Term] +id: GO:0099151 +name: regulation of postsynaptic density assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099150 ! regulation of postsynaptic specialization assembly +is_a: GO:1904889 ! regulation of excitatory synapse assembly +is_a: GO:1905874 ! regulation of postsynaptic density organization +relationship: regulates GO:0097107 ! postsynaptic density assembly + +[Term] +id: GO:0099152 +name: regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles." [GOC:dos, PMID:20098723] +subset: goslim_synapse +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:1902473 ! regulation of protein localization to synapse +is_a: GO:1902683 ! regulation of receptor localization to synapse +is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport +relationship: regulates GO:0098887 ! neurotransmitter receptor transport, endosome to postsynaptic membrane + +[Term] +id: GO:0099153 +name: synaptic transmission, serotonergic +namespace: biological_process +def: "The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] +synonym: "serotonergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099154 +name: serotonergic synapse +namespace: cellular_component +def: "A synapse that uses serotonin as a neurotransmitter." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0099155 +name: synaptic transmission, noradrenergic +namespace: biological_process +def: "The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] +synonym: "noradrenergic synaptic transmission" EXACT [] +is_a: GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099156 +name: cell-cell signaling via exosome +namespace: biological_process +def: "Cell-cell signaling in which the ligand is carried between cells by an exosome." [GOC:dos, PMID:19837038] +synonym: "exosome mediated" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0099157 +name: trans-synaptic signalling via exosome +namespace: biological_process +def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] +subset: goslim_synapse +synonym: "exosome mediated transynaptic signalling" EXACT [] +is_a: GO:0099156 ! cell-cell signaling via exosome +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099158 +name: regulation of recycling endosome localization within postsynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse." [GOC:dos, PMID:20098723] +subset: goslim_synapse +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:1903421 ! regulation of synaptic vesicle recycling +relationship: regulates GO:0036466 ! synaptic vesicle recycling via endosome + +[Term] +id: GO:0099159 +name: regulation of modification of postsynaptic structure +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic structure." [GOC:dos] +subset: goslim_synapse +synonym: "regulation of postsynapse remodelling" EXACT [] +is_a: GO:1905244 ! regulation of modification of synaptic structure +relationship: regulates GO:0099010 ! modification of postsynaptic structure + +[Term] +id: GO:0099160 +name: postsynaptic intermediate filament cytoskeleton +namespace: cellular_component +def: "The intermediate filament cytoskeleton that is part of a postsynapse." [GOC:dos, PMID:25869803] +subset: goslim_synapse +is_a: GO:0045111 ! intermediate filament cytoskeleton +is_a: GO:0099571 ! postsynaptic cytoskeleton + +[Term] +id: GO:0099161 +name: regulation of presynaptic dense core granule exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis." [GOC:dos, PMID:17881523] +subset: goslim_synapse +synonym: "regulation of presynaptic dense core vesicle exocytosis" EXACT syngo_official_label [] +is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission +is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter +is_a: GO:1905413 ! regulation of dense core granule exocytosis +relationship: regulates GO:0099525 ! presynaptic dense core vesicle exocytosis + +[Term] +id: GO:0099162 +name: regulation of neurotransmitter loading into synaptic vesicle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles." [GOC:dos, PMID:25176177] +subset: goslim_synapse +synonym: "regulation of neurotransmitter uptake into synaptic vesicle" EXACT [PMID:15217342] +synonym: "regulation of synaptic vesicle neurotransmitter loading" EXACT syngo_official_label [] +is_a: GO:0051588 ! regulation of neurotransmitter transport +is_a: GO:0098693 ! regulation of synaptic vesicle cycle +relationship: regulates GO:0098700 ! neurotransmitter loading into synaptic vesicle + +[Term] +id: GO:0099163 +name: synaptic signaling by nitric oxide +namespace: biological_process +def: "Cell-cell signaling to or from a synapse, mediated by nitric oxide." [GOC:dos, PMID:19038221] +subset: goslim_synapse +is_a: GO:0099536 ! synaptic signaling + +[Term] +id: GO:0099164 +name: postsynaptic specialization membrane of symmetric synapse +namespace: cellular_component +def: "The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099634 ! postsynaptic specialization membrane +relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse + +[Term] +id: GO:0099165 +name: postsynaptic specialization of symmetric synapse, intracellular component +namespace: cellular_component +def: "A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099091 ! postsynaptic specialization, intracellular component +relationship: part_of GO:0099629 ! postsynaptic specialization of symmetric synapse + +[Term] +id: GO:0099166 +name: intrinsic component of postsynaptic specialization membrane of symmetric synapse +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos] +subset: goslim_synapse +synonym: "intrinsic to postsynaptic specialization membrane of symmetric synapse" NARROW [] +is_a: GO:0098948 ! intrinsic component of postsynaptic specialization membrane +relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse + +[Term] +id: GO:0099167 +name: integral component of postsynaptic specialization membrane of symmetric synapse +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099060 ! integral component of postsynaptic specialization membrane +is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse + +[Term] +id: GO:0099168 +name: extrinsic component of postsynaptic specialization membrane of symmetric synapse +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098892 ! extrinsic component of postsynaptic specialization membrane +relationship: part_of GO:0099164 ! postsynaptic specialization membrane of symmetric synapse + +[Term] +id: GO:0099169 +name: anchored component of postsynaptic specialization membrane of symmetric synapse +namespace: cellular_component +def: "The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099030 ! anchored component of postsynaptic specialization membrane +is_a: GO:0099166 ! intrinsic component of postsynaptic specialization membrane of symmetric synapse + +[Term] +id: GO:0099170 +name: postsynaptic modulation of chemical synaptic transmission +namespace: biological_process +def: "Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission." [GOC:dos] +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission + +[Term] +id: GO:0099171 +name: presynaptic modulation of chemical synaptic transmission +namespace: biological_process +def: "Any process, acting in the presynapse that results in modulation of chemical synaptic transmission." [GOC:dos] +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission + +[Term] +id: GO:0099172 +name: presynapse organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse." [GOC:dos] +subset: goslim_synapse +synonym: "presynapse development" EXACT [] +synonym: "presynapse morphogenesis" RELATED [GOC:BHF] +synonym: "presynapse organisation" EXACT [] +synonym: "presynapse organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0099173 +name: postsynapse organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse." [GOC:dos] +subset: goslim_synapse +synonym: "postsynapse development" EXACT [] +synonym: "postsynapse morphogenesis" RELATED [GOC:BHF] +synonym: "postsynapse organisation" EXACT [] +synonym: "postsynapse organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0099174 +name: regulation of presynapse organization +namespace: biological_process +def: "Any process that modulates the physical form of a presynapse." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_synapse +synonym: "regulation of presynapse organisation" EXACT [GOC:mah] +synonym: "regulation of presynapse organization and biogenesis" RELATED [GOC:mah] +synonym: "regulation of presynapse structure" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0099172 ! presynapse organization + +[Term] +id: GO:0099175 +name: regulation of postsynapse organization +namespace: biological_process +def: "Any process that modulates the physical form of a postsynapse." [GOC:ai, GOC:dph, GOC:tb] +subset: goslim_synapse +synonym: "regulation of postsynapse organisation" EXACT [GOC:mah] +synonym: "regulation of postsynapse organization and biogenesis" RELATED [GOC:mah] +synonym: "regulation of postsynapse structure" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0099173 ! postsynapse organization + +[Term] +id: GO:0099176 +name: regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex." [GOC:dos, PMID:23209303] +subset: goslim_synapse +synonym: "regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +is_a: GO:0099177 ! regulation of trans-synaptic signaling +relationship: regulates GO:0098942 ! retrograde trans-synaptic signaling by trans-synaptic protein complex + +[Term] +id: GO:0099177 +name: regulation of trans-synaptic signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling." [GOC:dos] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +relationship: regulates GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099178 +name: regulation of retrograde trans-synaptic signaling by endocanabinoid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by an endocannabinoid." [GOC:dos, PMID:15664177] +synonym: "regulation of endocannabinoid-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +is_a: GO:0099177 ! regulation of trans-synaptic signaling +relationship: regulates GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid + +[Term] +id: GO:0099179 +name: regulation of synaptic membrane adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes." [GOC:dos] +subset: goslim_synapse +synonym: "regulation of synapse adhesion between pre- and post-synapse" EXACT syngo_official_label [] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0099560 ! synaptic membrane adhesion + +[Term] +id: GO:0099180 +name: zinc ion import into synaptic vesicle +namespace: biological_process +def: "The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle." [PMID:9990090] +subset: goslim_synapse +synonym: "zinc import into synaptic vesicle" EXACT [] +synonym: "Zn2+ import into synaptic vesicle" EXACT [] +is_a: GO:0062111 ! zinc ion import into organelle + +[Term] +id: GO:0099181 +name: structural constituent of presynapse +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a presynapse." [GOC:dos, PMID:23751498] +subset: goslim_synapse +is_a: GO:0098918 ! structural constituent of synapse + +[Term] +id: GO:0099182 +name: presynaptic intermediate filament cytoskeleton +namespace: cellular_component +def: "The intermediate filament cytoskeleton that is part of a presynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045111 ! intermediate filament cytoskeleton +is_a: GO:0099569 ! presynaptic cytoskeleton + +[Term] +id: GO:0099183 +name: trans-synaptic signaling by BDNF, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099191 ! trans-synaptic signaling by BDNF +is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission + +[Term] +id: GO:0099184 +name: structural constituent of postsynaptic intermediate filament cytoskeleton +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005200 ! structural constituent of cytoskeleton +is_a: GO:0099186 ! structural constituent of postsynapse + +[Term] +id: GO:0099185 +name: postsynaptic intermediate filament cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0045104 ! intermediate filament cytoskeleton organization +is_a: GO:0099188 ! postsynaptic cytoskeleton organization + +[Term] +id: GO:0099186 +name: structural constituent of postsynapse +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of a postsynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098918 ! structural constituent of synapse + +[Term] +id: GO:0099187 +name: presynaptic cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton." [GOC:dos] +is_a: GO:0007010 ! cytoskeleton organization +relationship: part_of GO:0099172 ! presynapse organization + +[Term] +id: GO:0099188 +name: postsynaptic cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton." [GOC:dos] +subset: goslim_synapse +is_a: GO:0007010 ! cytoskeleton organization +relationship: part_of GO:0099173 ! postsynapse organization + +[Term] +id: GO:0099189 +name: postsynaptic spectrin-associated cytoskeleton +namespace: cellular_component +def: "The portion of the spectrin-associated cytoskeleton contained within the postsynapse." [GOC:dos, PMID:28576936] +subset: goslim_synapse +is_a: GO:0014731 ! spectrin-associated cytoskeleton +is_a: GO:0099571 ! postsynaptic cytoskeleton + +[Term] +id: GO:0099190 +name: postsynaptic spectrin-associated cytoskeleton organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse." [GOC:dos, PMID:28576936] +subset: goslim_synapse +is_a: GO:0099188 ! postsynaptic cytoskeleton organization + +[Term] +id: GO:0099191 +name: trans-synaptic signaling by BDNF +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft." [GOC:dos] +subset: goslim_synapse +synonym: "trans-synaptic signaling by brain-derived neurotrophic factor" EXACT [] +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099192 +name: cerebellar Golgi cell to granule cell synapse +namespace: cellular_component +def: "A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell." [PMID:26134650] +subset: goslim_synapse +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0099240 +name: intrinsic component of synaptic membrane +namespace: cellular_component +def: "The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] +subset: goslim_synapse +synonym: "intrinsic to synaptic membrane" NARROW [] +is_a: GO:0031226 ! intrinsic component of plasma membrane +relationship: part_of GO:0097060 ! synaptic membrane + +[Term] +id: GO:0099243 +name: extrinsic component of synaptic membrane +namespace: cellular_component +def: "The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +subset: goslim_synapse +is_a: GO:0019897 ! extrinsic component of plasma membrane +relationship: part_of GO:0097060 ! synaptic membrane + +[Term] +id: GO:0099400 +name: caveola neck +namespace: cellular_component +def: "A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it." [GOC:pad, GOC:PARL, PMID:17227843] +is_a: GO:0098590 ! plasma membrane region +is_a: GO:0098857 ! membrane microdomain +relationship: part_of GO:0005901 ! caveola + +[Term] +id: GO:0099401 +name: caveola bulb +namespace: cellular_component +def: "The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins." [GOC:PARL, GOC:POD, PMID:17227843] +synonym: "caveola crater" EXACT [] +is_a: GO:0098857 ! membrane microdomain + +[Term] +id: GO:0099402 +name: plant organ development +namespace: biological_process +def: "Development of a plant organ, a multi-tissue plant structure that forms a functional unit." [GOC:dos] +synonym: "development of a plant organ" EXACT [] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0048731 ! system development + +[Term] +id: GO:0099403 +name: maintenance of mitotic sister chromatid cohesion, telomeric +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle." [GOC:BHF, GOC:BHF_telomere, GOC:dos, GOC:rph, PMID:26373281] +synonym: "maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:mah] +synonym: "maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:mah] +synonym: "maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah] +is_a: GO:0034088 ! maintenance of mitotic sister chromatid cohesion +relationship: part_of GO:0099404 ! mitotic sister chromatid cohesion, telomeric + +[Term] +id: GO:0099404 +name: mitotic sister chromatid cohesion, telomeric +namespace: biological_process +def: "The cell cycle process in which telomeres of sister chromatids are joined during mitosis." [GOC:BHF, GOC:BHF_telomere, GOC:mah, GOC:rph, PMID:26373281] +synonym: "mitotic sister chromatid cohesion at telomere" EXACT [GOC:mah] +synonym: "sister chromatid cohesion at telomere at mitosis" EXACT [GOC:mah] +synonym: "telomeric mitotic sister chromatin cohesion" EXACT [GOC:mah] +is_a: GO:0007064 ! mitotic sister chromatid cohesion + +[Term] +id: GO:0099500 +name: vesicle fusion to plasma membrane +namespace: biological_process +def: "Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space." [GOC:aruk, GOC:bc, ISBN:0071120009, PMID:18618940] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0140029 ! exocytic process + +[Term] +id: GO:0099501 +name: exocytic vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding an exocytic vesicle." [GOC:dos] +synonym: "secretory vesicle membrane" BROAD [] +is_a: GO:0030658 ! transport vesicle membrane +relationship: part_of GO:0070382 ! exocytic vesicle + +[Term] +id: GO:0099502 +name: calcium-dependent activation of synaptic vesicle fusion +namespace: biological_process +def: "The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane." [PMID:23060190] +subset: goslim_synapse +is_a: GO:0031632 ! positive regulation of synaptic vesicle fusion to presynaptic active zone membrane +relationship: part_of GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:0099503 +name: secretory vesicle +namespace: cellular_component +def: "A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space." [GOC:dos] +subset: goslim_drosophila +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0099504 +name: synaptic vesicle cycle +namespace: biological_process +def: "A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters." [GOC:aruk, GOC:bc, PMID:15217342] +subset: goslim_synapse +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099003 ! vesicle-mediated transport in synapse + +[Term] +id: GO:0099505 +name: regulation of presynaptic membrane potential +namespace: biological_process +def: "Any process that modulates the potential difference across a presynaptic membrane." [GOC:dph, GOC:ef] +subset: goslim_synapse +synonym: "regulation of pre-synaptic membrane potential" EXACT [] +is_a: GO:0042391 ! regulation of membrane potential + +[Term] +id: GO:0099506 +name: synaptic vesicle transport along actin filament +namespace: biological_process +def: "The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0030050 ! vesicle transport along actin filament +is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport + +[Term] +id: GO:0099507 +name: ligand-gated ion channel activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:15145529, PMID:19558451] +subset: goslim_synapse +synonym: "ligand gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] +synonym: "ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] +synonym: "ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] +synonym: "ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] +is_a: GO:0015276 ! ligand-gated ion channel activity + +[Term] +id: GO:0099508 +name: voltage-gated ion channel activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse." [GOC:dos] +subset: goslim_synapse +synonym: "voltage gated ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] +synonym: "voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] +synonym: "voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential" EXACT [] +synonym: "voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential" EXACT [] +is_a: GO:0005244 ! voltage-gated ion channel activity + +[Term] +id: GO:0099509 +name: regulation of presynaptic cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that regulates the concentration of calcium in the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +synonym: "regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration +is_a: GO:0070050 ! neuron cellular homeostasis + +[Term] +id: GO:0099510 +name: calcium ion binding involved in regulation of cytosolic calcium ion concentration +namespace: molecular_function +def: "The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] +synonym: "regulation of cytosolic calcium ion concentration by calcium ion buffering" EXACT [] +is_a: GO:0005509 ! calcium ion binding + +[Term] +id: GO:0099511 +name: voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels +namespace: molecular_function +def: "Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:0099512 +name: supramolecular fiber +namespace: cellular_component +alt_id: GO:0043205 +def: "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." [GOC:dos] +synonym: "fibril" RELATED [] +is_a: GO:0099081 ! supramolecular polymer + +[Term] +id: GO:0099513 +name: polymeric cytoskeletal fiber +namespace: cellular_component +def: "A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits." [GOC:dos] +is_a: GO:0099512 ! supramolecular fiber +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0099514 +name: synaptic vesicle cytoskeletal transport +namespace: biological_process +def: "The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0048489 ! synaptic vesicle transport +is_a: GO:0099518 ! vesicle cytoskeletal trafficking + +[Term] +id: GO:0099515 +name: actin filament-based transport +namespace: biological_process +def: "The transport of organelles or other particles from one location in the cell to another along actin filaments." [GOC:dos, GOC:dph, GOC:mah, GOC:tb] +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport + +[Term] +id: GO:0099517 +name: synaptic vesicle transport along microtubule +namespace: biological_process +def: "The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0099514 ! synaptic vesicle cytoskeletal transport + +[Term] +id: GO:0099518 +name: vesicle cytoskeletal trafficking +namespace: biological_process +def: "The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins." [GOC:ecd, GOC:rl] +synonym: "cytoskeletal fiber-based vesicle localization" EXACT [GOC:rl] +synonym: "vesicle cytoskeletal transport" EXACT [] +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport +is_a: GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:0099519 +name: dense core granule cytoskeletal transport +namespace: biological_process +def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451] +synonym: "dense core vesicle cytoskeletal trafficking" EXACT [] +is_a: GO:0099518 ! vesicle cytoskeletal trafficking +is_a: GO:1901950 ! dense core granule transport + +[Term] +id: GO:0099520 +name: ion antiporter activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos] +subset: goslim_synapse +synonym: "ion antiporter activity involved in regulation of pre-synaptic membrane potential" EXACT [] +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0099521 +name: ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential." [GOC:dos, PMID:17220883] +subset: goslim_synapse +synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential" EXACT [] +synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential" EXACT [] +is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity + +[Term] +id: GO:0099522 +name: cytosolic region +namespace: cellular_component +def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] +subset: gocheck_do_not_annotate +synonym: "region of cytosol" EXACT [] +is_a: GO:0005829 ! cytosol + +[Term] +id: GO:0099523 +name: presynaptic cytosol +namespace: cellular_component +def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099522 ! cytosolic region +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0099524 +name: postsynaptic cytosol +namespace: cellular_component +def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099522 ! cytosolic region +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0099525 +name: presynaptic dense core vesicle exocytosis +namespace: biological_process +def: "The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels." [PMID:17553987, PMID:24653208] +subset: goslim_synapse +is_a: GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter +is_a: GO:0099011 ! neuronal dense core vesicle exocytosis + +[Term] +id: GO:0099526 +name: presynapse to nucleus signaling pathway +namespace: biological_process +def: "A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077] +comment: This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term. +subset: goslim_synapse +synonym: "presynaptic signaling to nucleus" EXACT [] +is_a: GO:0098928 ! presynaptic signal transduction + +[Term] +id: GO:0099527 +name: postsynapse to nucleus signaling pathway +namespace: biological_process +def: "A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications)." [GOC:dos, PMID:24317321, PMID:25652077] +subset: goslim_synapse +synonym: "postsynaptic signaling to nucleus" EXACT [] +is_a: GO:0098926 ! postsynaptic signal transduction + +[Term] +id: GO:0099528 +name: G protein-coupled neurotransmitter receptor activity +namespace: molecular_function +def: "Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] +synonym: "G-protein coupled neurotransmitter receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0099529 +name: neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel)." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity + +[Term] +id: GO:0099530 +name: G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane." [GOC:dos] +subset: goslim_synapse +synonym: "G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0099531 +name: presynaptic process involved in chemical synaptic transmission +namespace: biological_process +def: "The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission." [GOC:dos] +subset: gocheck_do_not_annotate +subset: goslim_synapse +is_a: GO:0050877 ! nervous system process +relationship: part_of GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099532 +name: synaptic vesicle endosomal processing +namespace: biological_process +def: "The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:aruk, GOC:bc, GOC:dos] +comment: This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. +subset: goslim_synapse +synonym: "synaptic vesicle processing via endosome" EXACT [] +is_a: GO:0016197 ! endosomal transport + +[Term] +id: GO:0099533 +name: positive regulation of presynaptic cytosolic calcium concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +is_a: GO:0099509 ! regulation of presynaptic cytosolic calcium ion concentration + +[Term] +id: GO:0099534 +name: calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] +subset: goslim_synapse +synonym: "calcium ion binding involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "presynaptic calcium ion buffering" EXACT [] +synonym: "regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering" EXACT [] +is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0099535 +name: synapse-associated extracellular matrix +namespace: cellular_component +def: "The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:dos] +subset: goslim_synapse +synonym: "extra-synaptic extracellular matrix" EXACT [] +is_a: GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0099536 +name: synaptic signaling +namespace: biological_process +def: "Cell-cell signaling to, from or within a synapse." [GOC:dos] +subset: goslim_drosophila +subset: goslim_synapse +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0099537 +name: trans-synaptic signaling +namespace: biological_process +def: "Cell-cell signaling in either direction across the synaptic cleft." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099536 ! synaptic signaling + +[Term] +id: GO:0099538 +name: synaptic signaling via neuropeptide +namespace: biological_process +def: "Cell-cell signaling to or from a synapse, mediated by a peptide." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099536 ! synaptic signaling + +[Term] +id: GO:0099539 +name: neuropeptide secretion from presynapse +namespace: biological_process +def: "The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration." [PMID:17553987, PMID:24653208] +subset: goslim_synapse +synonym: "neuropeptide secretion from presynapse via dense core granule exocytosis" EXACT [] +is_a: GO:0002790 ! peptide secretion +is_a: GO:0099525 ! presynaptic dense core vesicle exocytosis +relationship: part_of GO:0099538 ! synaptic signaling via neuropeptide + +[Term] +id: GO:0099540 +name: trans-synaptic signaling by neuropeptide +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099537 ! trans-synaptic signaling +is_a: GO:0099538 ! synaptic signaling via neuropeptide + +[Term] +id: GO:0099541 +name: trans-synaptic signaling by lipid +namespace: biological_process +def: "Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099542 +name: trans-synaptic signaling by endocannabinoid +namespace: biological_process +def: "Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099541 ! trans-synaptic signaling by lipid + +[Term] +id: GO:0099543 +name: trans-synaptic signaling by soluble gas +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099544 +name: perisynaptic space +namespace: cellular_component +def: "The extracellular region immediately adjacent to to a synapse." [GOC:dos] +subset: goslim_synapse +synonym: "extrasynaptic space" EXACT syngo_official_label [] +is_a: GO:0005576 ! extracellular region + +[Term] +id: GO:0099545 +name: trans-synaptic signaling by trans-synaptic complex +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099537 ! trans-synaptic signaling + +[Term] +id: GO:0099546 +name: protein catabolic process, modulating synaptic transmission +namespace: biological_process +def: "Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission." [GOC:dos, PMID:23083742] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099547 +name: regulation of translation at synapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating translation occurring at the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0140243 ! regulation of translation at synapse + +[Term] +id: GO:0099548 +name: trans-synaptic signaling by nitric oxide +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099163 ! synaptic signaling by nitric oxide +is_a: GO:0099543 ! trans-synaptic signaling by soluble gas + +[Term] +id: GO:0099549 +name: trans-synaptic signaling by carbon monoxide +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099543 ! trans-synaptic signaling by soluble gas + +[Term] +id: GO:0099550 +name: trans-synaptic signaling, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099537 ! trans-synaptic signaling +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099551 +name: trans-synaptic signaling by neuropeptide, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099540 ! trans-synaptic signaling by neuropeptide +is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission + +[Term] +id: GO:0099552 +name: trans-synaptic signaling by lipid, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099541 ! trans-synaptic signaling by lipid +is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission + +[Term] +id: GO:0099553 +name: trans-synaptic signaling by endocannabinoid, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:21531987] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099542 ! trans-synaptic signaling by endocannabinoid +is_a: GO:0099552 ! trans-synaptic signaling by lipid, modulating synaptic transmission + +[Term] +id: GO:0099554 +name: trans-synaptic signaling by soluble gas, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099543 ! trans-synaptic signaling by soluble gas +is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission + +[Term] +id: GO:0099555 +name: trans-synaptic signaling by nitric oxide, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099548 ! trans-synaptic signaling by nitric oxide +is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission + +[Term] +id: GO:0099556 +name: trans-synaptic signaling by carbon monoxide, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099549 ! trans-synaptic signaling by carbon monoxide +is_a: GO:0099554 ! trans-synaptic signaling by soluble gas, modulating synaptic transmission + +[Term] +id: GO:0099557 +name: trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission +namespace: biological_process +def: "Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse." [GOC:dos, PMID:19029886] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099545 ! trans-synaptic signaling by trans-synaptic complex +is_a: GO:0099550 ! trans-synaptic signaling, modulating synaptic transmission + +[Term] +id: GO:0099558 +name: maintenance of synapse structure +namespace: biological_process +def: "A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds." [GOC:dos, PMID:24449494, PMID:25611509] +subset: goslim_synapse +synonym: "synaptic maintenance" EXACT [] +is_a: GO:0034331 ! cell junction maintenance +is_a: GO:0050808 ! synapse organization + +[Term] +id: GO:0099559 +name: maintenance of alignment of postsynaptic density and presynaptic active zone +namespace: biological_process +def: "The process by which alignment between postsynaptic density and presynaptic active zone is maintained." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099558 ! maintenance of synapse structure + +[Term] +id: GO:0099560 +name: synaptic membrane adhesion +namespace: biological_process +def: "The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane." [GOC:dos] +subset: goslim_synapse +synonym: "synapse adhesion between pre- and post-synapse" EXACT syngo_official_label [] +is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0099561 +name: synaptic membrane adhesion to extracellular matrix +namespace: biological_process +def: "The binding of a synaptic membrane to the extracellular matrix via adhesion molecules." [GOC:dos] +subset: goslim_synapse +is_a: GO:0007160 ! cell-matrix adhesion +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:0099562 +name: maintenance of postsynaptic density structure +namespace: biological_process +def: "A process which maintains the organization and the arrangement of proteins in the presynaptic density." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098880 ! maintenance of postsynaptic specialization structure + +[Term] +id: GO:0099563 +name: modification of synaptic structure +namespace: biological_process +def: "Any process that modifies the structure/morphology of a synapse." [GOC:dos] +comment: This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. +subset: goslim_synapse +synonym: "synapse remodelling" EXACT [] +is_a: GO:0050808 ! synapse organization + +[Term] +id: GO:0099564 +name: modification of synaptic structure, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission via modification of the structure of the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099563 ! modification of synaptic structure +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099565 +name: chemical synaptic transmission, postsynaptic +namespace: biological_process +def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos] +subset: gocheck_do_not_annotate +subset: goslim_synapse +synonym: "postsynaptic process involved in chemical synaptic transmission" RELATED syngo_official_label [] +is_a: GO:0050877 ! nervous system process +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling +relationship: part_of GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099566 +name: regulation of postsynaptic cytosolic calcium ion concentration +namespace: biological_process +def: "Any process that regulates the concentration of calcium in the postsynaptic cytosol." [GOC:dos] +subset: goslim_synapse +synonym: "regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0099567 +name: calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations." [PMID:24442513, PMID:26190970] +subset: goslim_synapse +synonym: "calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "postsynaptic calcium ion buffering" EXACT [] +synonym: "regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering" RELATED [] +is_a: GO:0099510 ! calcium ion binding involved in regulation of cytosolic calcium ion concentration + +[Term] +id: GO:0099568 +name: cytoplasmic region +namespace: cellular_component +def: "Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm." [GOC:dos] +subset: gocheck_do_not_annotate +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:0099569 +name: presynaptic cytoskeleton +namespace: cellular_component +def: "The portion of the cytoskeleton contained within the presynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005856 ! cytoskeleton +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0099571 +name: postsynaptic cytoskeleton +namespace: cellular_component +def: "The portion of the cytoskeleton contained within the postsynapse." [GOC:dos, PMID:19889835] +subset: goslim_synapse +is_a: GO:0005856 ! cytoskeleton +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0099572 +name: postsynaptic specialization +namespace: cellular_component +def: "A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [PMID:22046028] +subset: goslim_synapse +is_a: GO:0043226 ! organelle +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0099573 +name: glutamatergic postsynaptic density +namespace: cellular_component +def: "The post-synaptic specialization of a glutamatergic excitatory synapse." [GOC:dos] +subset: goslim_synapse +synonym: "postsynaptic specialization, glutamatergic neuron-to-neuron synapse" EXACT syngo_official_label [] +is_a: GO:0014069 ! postsynaptic density + +[Term] +id: GO:0099574 +name: regulation of protein catabolic process at synapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating protein degradation at the synapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +is_a: GO:0140250 ! regulation protein catabolic process at synapse + +[Term] +id: GO:0099575 +name: regulation of protein catabolic process at presynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission + +[Term] +id: GO:0099576 +name: regulation of protein catabolic process at postsynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0042176 ! regulation of protein catabolic process +is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission + +[Term] +id: GO:0099577 +name: regulation of translation at presynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating translation occurring at the presynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission +is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission +is_a: GO:0140244 ! regulation of translation at presynapse + +[Term] +id: GO:0099578 +name: regulation of translation at postsynapse, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse." [GOC:dos] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0099170 ! postsynaptic modulation of chemical synaptic transmission +is_a: GO:0099547 ! regulation of translation at synapse, modulating synaptic transmission +is_a: GO:0140245 ! regulation of translation at postsynapse + +[Term] +id: GO:0099579 +name: G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential." [GOC:dos] +subset: goslim_synapse +synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" EXACT [] +is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity +is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential +is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential + +[Term] +id: GO:0099580 +name: ion antiporter activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos] +subset: goslim_synapse +synonym: "ion antiporter activity involved in regulation of post-synaptic membrane potential" EXACT [] +is_a: GO:0015297 ! antiporter activity + +[Term] +id: GO:0099581 +name: ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential." [GOC:dos] +subset: goslim_synapse +synonym: "ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential" EXACT [] +synonym: "ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential" EXACT [] +is_a: GO:0042625 ! ATPase-coupled ion transmembrane transporter activity + +[Term] +id: GO:0099582 +name: neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +synonym: "neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0030594 ! neurotransmitter receptor activity + +[Term] +id: GO:0099583 +name: neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol." [GOC:dos] +subset: goslim_synapse +synonym: "neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0098960 ! postsynaptic neurotransmitter receptor activity + +[Term] +id: GO:0099585 +name: release of sequestered calcium ion into presynaptic cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration + +[Term] +id: GO:0099586 +name: release of sequestered calcium ion into postsynaptic cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0099588 ! positive regulation of postsynaptic cytosolic calcium concentration + +[Term] +id: GO:0099587 +name: inorganic ion import across plasma membrane +namespace: biological_process +def: "The directed movement of inorganic ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "inorganic ion import into cell" EXACT [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098660 ! inorganic ion transmembrane transport +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0099588 +name: positive regulation of postsynaptic cytosolic calcium concentration +namespace: biological_process +def: "Any process that increases the concentration of calcium ions in the postsynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration +is_a: GO:0099566 ! regulation of postsynaptic cytosolic calcium ion concentration + +[Term] +id: GO:0099589 +name: serotonin receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [GOC:dos] +is_a: GO:0004888 ! transmembrane signaling receptor activity + +[Term] +id: GO:0099590 +name: neurotransmitter receptor internalization +namespace: biological_process +def: "A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor." [GOC:dos] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0031623 ! receptor internalization + +[Term] +id: GO:0099592 +name: endocytosed synaptic vesicle processing via endosome +namespace: biological_process +def: "The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." [GOC:dos] +synonym: "synaptic vesicle processing via endosome involved in synaptic vesicle recycling" EXACT [] +is_a: GO:0099003 ! vesicle-mediated transport in synapse +is_a: GO:0099532 ! synaptic vesicle endosomal processing +relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome + +[Term] +id: GO:0099593 +name: endocytosed synaptic vesicle to endosome fusion +namespace: biological_process +def: "Fusion of an endocytosed synaptic vesicle with an endosome." [GOC:dos] +is_a: GO:0016189 ! synaptic vesicle to endosome fusion +relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome + +[Term] +id: GO:0099601 +name: regulation of neurotransmitter receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:0099602 +name: neurotransmitter receptor regulator activity +namespace: molecular_function +def: "A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing." [GOC:dos, PMID:12740117, PMID:18387948] +is_a: GO:0030545 ! signaling receptor regulator activity + +[Term] +id: GO:0099604 +name: ligand-gated calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:dos] +is_a: GO:0005262 ! calcium channel activity +is_a: GO:0099094 ! ligand-gated cation channel activity + +[Term] +id: GO:0099605 +name: regulation of action potential firing rate +namespace: biological_process +def: "Any process that regulates the frequency of action potentials in a spike train." [ISBN:978-0071390118] +is_a: GO:0098900 ! regulation of action potential + +[Term] +id: GO:0099606 +name: microtubule plus-end directed mitotic chromosome migration +namespace: biological_process +def: "The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression." [GOC:dos, PMID:26258632, PMID:26705896] +synonym: "plus-end directed chromosome gliding" EXACT [PMID:26258632] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0051303 ! establishment of chromosome localization +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007080 ! mitotic metaphase plate congression + +[Term] +id: GO:0099607 +name: lateral attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate)." [PMID:26258632, PMID:26705896] +is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:0099608 +name: regulation of action potential firing pattern +namespace: biological_process +def: "Any process that regulates the temporal pattern of a sequence of action potentials in a neuron." [ISBN:978-0071390118] +synonym: "spike train sculpting" EXACT [] +is_a: GO:0098900 ! regulation of action potential +relationship: regulates GO:0098874 ! spike train + +[Term] +id: GO:0099609 +name: microtubule lateral binding +namespace: molecular_function +def: "Binding to the side of a microtubule." [GOC:dos] +is_a: GO:0008017 ! microtubule binding + +[Term] +id: GO:0099610 +name: action potential initiation +namespace: biological_process +def: "The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate." [ISBN:978-0071390118, PMID:19439602] +synonym: "action potential firing" EXACT [] +synonym: "action potential triggering" EXACT [] +is_a: GO:0001508 ! action potential + +[Term] +id: GO:0099611 +name: regulation of action potential firing threshold +namespace: biological_process +def: "Any process that regulates the potential at which an axon potential is triggered." [ISBN:978-0071390118] +is_a: GO:0098900 ! regulation of action potential + +[Term] +id: GO:0099612 +name: protein localization to axon +namespace: biological_process +def: "A process in which a protein is transported to or maintained in a location within an axon." [GOC:dos, PMID:26157139] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:0099613 +name: protein localization to cell wall +namespace: biological_process +def: "The process of directing proteins towards the cell-wall." [ISBN:0716731363] +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0099614 +name: protein localization to spore cell wall +namespace: biological_process +def: "A process in which a protein is transported, tethered to or otherwise maintained in a spore cell wall." [GOC:dos] +synonym: "protein targeting to spore cell wall" RELATED [] +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0099615 +name: (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor." [PMID:26774271] +synonym: "D-2HG-pyruvate transhydrogenase activity" EXACT [] +synonym: "R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity" EXACT [] +is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors + +[Term] +id: GO:0099616 +name: extrinsic component of matrix side of mitochondrial inner membrane +namespace: cellular_component +def: "The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos] +is_a: GO:0031314 ! extrinsic component of mitochondrial inner membrane +relationship: part_of GO:0099617 ! matrix side of mitochondrial inner membrane + +[Term] +id: GO:0099617 +name: matrix side of mitochondrial inner membrane +namespace: cellular_component +def: "The side (leaflet) of the mitochondrial inner membrane that faces the matrix." [GOC:dos] +is_a: GO:0098576 ! lumenal side of membrane +relationship: part_of GO:0005743 ! mitochondrial inner membrane + +[Term] +id: GO:0099618 +name: UDP-glucuronic acid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+." [GOC:al, GOC:dos] +synonym: "UDP-GlcUA decarboxylase activity" EXACT [] +xref: EC:1.1.1.305 +xref: RHEA:24702 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0099619 +name: UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [PMID:15695810, PMID:15807526, PMID:15809294, PMID:15939024, PMID:17928292] +synonym: "10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity" EXACT [] +synonym: "ArnAFT activity" EXACT [] +synonym: "UDP-L-Ara4N formyltransferase activity" EXACT [] +xref: EC:2.1.2.13 +xref: RHEA:24706 +is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity + +[Term] +id: GO:0099620 +name: UDP-4-amino-4-deoxy-L-arabinose aminotransferase +namespace: molecular_function +def: "Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate." [GOC:al, GOC:dos, PMID:12429098, PMID:12704196] +synonym: "UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase" EXACT [] +synonym: "UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase" EXACT [] +synonym: "UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase" EXACT [] +synonym: "UDP-Ara4O aminotransferase" EXACT [] +synonym: "UDP-L-Ara4N transaminase" EXACT [] +xref: EC:2.6.1.87 +xref: RHEA:24710 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0099621 +name: undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity +namespace: molecular_function +alt_id: GO:0103019 +def: "Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate." [GOC:al, GOC:dos, PMID:11706007, PMID:15695810] +synonym: "Ara4FN transferase activity" EXACT [] +synonym: "undecaprenyl phosphate-L-Ara4FN transferase activity" EXACT [] +synonym: "undecaprenyl-phosphate Ara4FN transferase activity" EXACT [] +xref: EC:2.4.2.53 +xref: MetaCyc:RXN0-3521 +xref: RHEA:27722 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0099622 +name: cardiac muscle cell membrane repolarization +namespace: biological_process +def: "The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0086009 ! membrane repolarization + +[Term] +id: GO:0099623 +name: regulation of cardiac muscle cell membrane repolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte." [GOC:BHF, GOC:dos, GOC:rl] +synonym: "heart repolarization" RELATED [] +synonym: "regulation of cardiac muscle cell repolarization" EXACT [] +synonym: "regulation of cardiomyocyte membrane repolarization" EXACT [] +is_a: GO:0060306 ! regulation of membrane repolarization +relationship: regulates GO:0099622 ! cardiac muscle cell membrane repolarization + +[Term] +id: GO:0099624 +name: atrial cardiac muscle cell membrane repolarization +namespace: biological_process +def: "The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF] +is_a: GO:0099622 ! cardiac muscle cell membrane repolarization + +[Term] +id: GO:0099625 +name: ventricular cardiac muscle cell membrane repolarization +namespace: biological_process +def: "The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] +is_a: GO:0099622 ! cardiac muscle cell membrane repolarization + +[Term] +id: GO:0099626 +name: voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels +namespace: molecular_function +def: "Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels." [GOC:dos, PMID:15548655] +subset: goslim_synapse +synonym: "voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels + +[Term] +id: GO:0099627 +name: neurotransmitter receptor cycle +namespace: biological_process +def: "The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping)." [GOC:dos] +is_a: GO:0099637 ! neurotransmitter receptor transport + +[Term] +id: GO:0099628 +name: neurotransmitter receptor diffusion trapping +namespace: biological_process +def: "The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane." [PMID:18832033] +subset: goslim_synapse +is_a: GO:0098953 ! receptor diffusion trapping + +[Term] +id: GO:0099629 +name: postsynaptic specialization of symmetric synapse +namespace: cellular_component +def: "A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses." [PMID:18832033] +subset: goslim_synapse +synonym: "postsynaptic density of inhibitory synapse" EXACT [PMID:18832033] +is_a: GO:0099572 ! postsynaptic specialization +relationship: part_of GO:0032280 ! symmetric synapse + +[Term] +id: GO:0099630 +name: postsynaptic neurotransmitter receptor cycle +namespace: biological_process +def: "The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane." [PMID:18832033] +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099627 ! neurotransmitter receptor cycle + +[Term] +id: GO:0099631 +name: postsynaptic endocytic zone cytoplasmic component +namespace: cellular_component +def: "The cytoplasmic component of the postsynaptic endocytic zone." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0098843 ! postsynaptic endocytic zone + +[Term] +id: GO:0099632 +name: protein transport within plasma membrane +namespace: biological_process +def: "A process in which protein is transported from one region of the plasma membrane to another." [GOC:dos] +is_a: GO:0032594 ! protein transport within lipid bilayer + +[Term] +id: GO:0099633 +name: protein localization to postsynaptic specialization membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. post synaptic density)." [GOC:dos] +synonym: "protein localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie] +is_a: GO:0033365 ! protein localization to organelle +is_a: GO:1903539 ! protein localization to postsynaptic membrane + +[Term] +id: GO:0099634 +name: postsynaptic specialization membrane +namespace: cellular_component +def: "The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated." [GOC:dos] +subset: goslim_synapse +is_a: GO:0097060 ! synaptic membrane +relationship: part_of GO:0045211 ! postsynaptic membrane +relationship: part_of GO:0099572 ! postsynaptic specialization + +[Term] +id: GO:0099635 +name: voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels +namespace: molecular_function +def: "Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099626 ! voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels + +[Term] +id: GO:0099636 +name: cytoplasmic streaming +namespace: biological_process +def: "The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains." [GOC:dos, Wikipedia:Cytoplasmic_streaming&oldid=706214009] +xref: Wikipedia:Cytoplasmic_streaming +is_a: GO:0016482 ! cytosolic transport + +[Term] +id: GO:0099637 +name: neurotransmitter receptor transport +namespace: biological_process +def: "The directed movement of neurotransmitter receptors." [GOC:dos] +subset: goslim_synapse +is_a: GO:0015031 ! protein transport +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0099638 +name: endosome to plasma membrane protein transport +namespace: biological_process +def: "The directed movement of proteins from the endosome to the plasma membrane in transport vesicles." [GOC:dos] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0032456 ! endocytic recycling +is_a: GO:0061951 ! establishment of protein localization to plasma membrane + +[Term] +id: GO:0099639 +name: neurotransmitter receptor transport, endosome to plasma membrane +namespace: biological_process +def: "The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles." [GOC:dos] +subset: goslim_synapse +is_a: GO:0098877 ! neurotransmitter receptor transport to plasma membrane +is_a: GO:0099638 ! endosome to plasma membrane protein transport + +[Term] +id: GO:0099640 +name: axo-dendritic protein transport +namespace: biological_process +def: "The directed movement of proteins along microtubules in neuron projections." [ISBN:0815316194] +subset: goslim_synapse +synonym: "axonal protein transport" NARROW [] +is_a: GO:0008088 ! axo-dendritic transport +is_a: GO:0098840 ! protein transport along microtubule + +[Term] +id: GO:0099641 +name: anterograde axonal protein transport +namespace: biological_process +def: "The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons." [GOC:dos] +subset: goslim_synapse +synonym: "anterograde axon cargo transport" BROAD [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0099640 ! axo-dendritic protein transport +is_a: GO:1905383 ! protein localization to presynapse + +[Term] +id: GO:0099642 +name: retrograde axonal protein transport +namespace: biological_process +def: "The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] +subset: goslim_synapse +synonym: "retrograde axon cargo transport" BROAD [] +is_a: GO:0008090 ! retrograde axonal transport +is_a: GO:0099640 ! axo-dendritic protein transport + +[Term] +id: GO:0099643 +name: signal release from synapse +namespace: biological_process +def: "Any signal release from a synapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0023061 ! signal release +relationship: part_of GO:0099536 ! synaptic signaling + +[Term] +id: GO:0099644 +name: protein localization to presynaptic membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a presynaptic membrane." [GOC:dos] +synonym: "protein localisation in presynaptic membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to presynaptic membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in presynaptic membrane" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1905383 ! protein localization to presynapse +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:0099645 +name: neurotransmitter receptor localization to postsynaptic specialization membrane +namespace: biological_process +def: "A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density)." [GOC:dos] +subset: goslim_synapse +synonym: "neurotransmitter receptor localisation in postsynaptic specialization membrane" EXACT [GOC:TermGenie] +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0099072 ! regulation of postsynaptic membrane neurotransmitter receptor levels +is_a: GO:0099633 ! protein localization to postsynaptic specialization membrane + +[Term] +id: GO:0099646 +name: neurotransmitter receptor transport, plasma membrane to endosome +namespace: biological_process +def: "Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome." [GOC:dos] +subset: goslim_synapse +is_a: GO:0036010 ! protein localization to endosome +is_a: GO:0048227 ! plasma membrane to endosome transport +is_a: GO:0072594 ! establishment of protein localization to organelle +is_a: GO:0099637 ! neurotransmitter receptor transport + +[Term] +id: GO:0099699 +name: integral component of synaptic membrane +namespace: cellular_component +def: "The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos] +subset: goslim_synapse +is_a: GO:0005887 ! integral component of plasma membrane +is_a: GO:0099240 ! intrinsic component of synaptic membrane + +[Term] +id: GO:0099703 +name: induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration +namespace: biological_process +def: "The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission." [GOC:dos, ISBN:9780071120005] +subset: goslim_synapse +is_a: GO:0099171 ! presynaptic modulation of chemical synaptic transmission +is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration +is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis +relationship: part_of GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0099738 +name: cell cortex region +namespace: cellular_component +def: "The complete extent of cell cortex that underlies some some region of the plasma membrane." [GOC:dos] +subset: gocheck_do_not_annotate +synonym: "perimembrane region" EXACT [] +is_a: GO:0005938 ! cell cortex +is_a: GO:0099568 ! cytoplasmic region + +[Term] +id: GO:0100001 +name: regulation of skeletal muscle contraction by action potential +namespace: biological_process +def: "Any action potential process that regulates skeletal muscle contraction." [GOC:cjm, GOC:obol] +is_a: GO:0001508 ! action potential +is_a: GO:0014819 ! regulation of skeletal muscle contraction + +[Term] +id: GO:0100002 +name: negative regulation of protein kinase activity by protein phosphorylation +namespace: biological_process +def: "Any protein phosphorylation process that negatively regulates protein kinase activity." [GOC:cjm, GOC:obol] +is_a: GO:0006468 ! protein phosphorylation + +[Term] +id: GO:0100003 +name: obsolete positive regulation of sodium ion transport by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sodium ion transport." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100004 +name: obsolete positive regulation of peroxisome organization by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates peroxisome organization." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100005 +name: obsolete positive regulation of ethanol catabolic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates ethanol catabolic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100006 +name: obsolete positive regulation of sulfite transport by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfite transport." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100007 +name: obsolete negative regulation of ceramide biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates ceramide biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100008 +name: regulation of fever generation by prostaglandin biosynthetic process +namespace: biological_process +def: "Any prostaglandin biosynthetic process process that regulates fever generation." [GOC:cjm, GOC:obol] +is_a: GO:0001516 ! prostaglandin biosynthetic process +relationship: regulates GO:0001660 ! fever generation + +[Term] +id: GO:0100009 +name: regulation of fever generation by prostaglandin secretion +namespace: biological_process +def: "Any prostaglandin secretion process that regulates fever generation." [GOC:cjm, GOC:obol] +is_a: GO:0032310 ! prostaglandin secretion +relationship: regulates GO:0001660 ! fever generation + +[Term] +id: GO:0100010 +name: positive regulation of fever generation by prostaglandin biosynthetic process +namespace: biological_process +def: "Any prostaglandin biosynthetic process process that positively_regulates fever generation." [GOC:cjm, GOC:obol] +is_a: GO:0100008 ! regulation of fever generation by prostaglandin biosynthetic process +relationship: positively_regulates GO:0001660 ! fever generation + +[Term] +id: GO:0100011 +name: positive regulation of fever generation by prostaglandin secretion +namespace: biological_process +def: "Any prostaglandin secretion process that positively_regulates fever generation." [GOC:cjm, GOC:obol] +is_a: GO:0100009 ! regulation of fever generation by prostaglandin secretion +relationship: positively_regulates GO:0001660 ! fever generation + +[Term] +id: GO:0100012 +name: regulation of heart induction by canonical Wnt signaling pathway +namespace: biological_process +def: "Any canonical Wnt signaling pathway process that regulates heart induction." [GOC:cjm, GOC:obol] +is_a: GO:0060070 ! canonical Wnt signaling pathway +is_a: GO:0090381 ! regulation of heart induction + +[Term] +id: GO:0100013 +name: obsolete positive regulation of fatty acid beta-oxidation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates fatty acid beta-oxidation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100014 +name: obsolete positive regulation of mating type switching by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates mating type switching." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100015 +name: obsolete positive regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates inositol biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100016 +name: obsolete regulation of thiamine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates thiamine biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100017 +name: obsolete negative regulation of cell-cell adhesion by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates single organismal cell-cell adhesion." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100018 +name: obsolete regulation of glucose import by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates glucose import." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100019 +name: obsolete regulation of cAMP-mediated signaling by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cAMP-mediated signaling." [GOC:cjm, GOC:obol] +comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter. +is_obsolete: true + +[Term] +id: GO:0100020 +name: obsolete regulation of transport by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates transport." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100021 +name: obsolete regulation of iron ion transport by transcription from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:0100022 +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates iron ion transport." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of iron ion import by transcription from RNA polymerase II promoter" RELATED [] +is_obsolete: true + +[Term] +id: GO:0100023 +name: obsolete regulation of meiotic nuclear division by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates meiotic nuclear division." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100024 +name: obsolete regulation of carbohydrate metabolic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates carbohydrate metabolic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100025 +name: obsolete negative regulation of cellular amino acid biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular amino acid biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100026 +name: positive regulation of DNA repair by transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any transcription from RNA polymerase II promoter process that positively regulates DNA repair." [GOC:cjm, GOC:obol] +is_a: GO:0006366 ! transcription by RNA polymerase II +relationship: positively_regulates GO:0006281 ! DNA repair + +[Term] +id: GO:0100027 +name: obsolete regulation of cell separation after cytokinesis by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cell separation after cytokinesis." [GOC:cjm, GOC:obol] +is_obsolete: true + +[Term] +id: GO:0100028 +name: obsolete regulation of conjugation with cellular fusion by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates conjugation with cellular fusion." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100029 +name: obsolete regulation of histone modification by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone modification." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:0100030 +name: obsolete regulation of histone acetylation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone acetylation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:0100031 +name: obsolete regulation of histone methylation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates histone methylation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:0100032 +name: obsolete positive regulation of phospholipid biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phospholipid biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100033 +name: obsolete regulation of fungal-type cell wall biogenesis by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fungal-type cell wall biogenesis." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100034 +name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates 4,6-pyruvylated galactose residue biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100035 +name: obsolete negative regulation of transmembrane transport by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates transmembrane transport." [GOC:cjm, GOC:obol] +comment: The term was obsoleted because it is better represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100036 +name: obsolete positive regulation of purine nucleotide biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates purine nucleotide biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100037 +name: obsolete positive regulation of cellular alcohol catabolic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates cellular alcohol catabolic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100038 +name: obsolete regulation of cellular response to oxidative stress by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates cellular response to oxidative stress." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100039 +name: obsolete regulation of pyrimidine nucleotide biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates pyrimidine nucleotide biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100040 +name: obsolete negative regulation of invasive growth in response to glucose limitation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates invasive growth in response to glucose limitation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100041 +name: obsolete positive regulation of pseudohyphal growth by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pseudohyphal growth." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100042 +name: obsolete negative regulation of pseudohyphal growth by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates pseudohyphal growth." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100043 +name: obsolete negative regulation of cellular response to alkaline pH by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular response to alkaline pH." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100044 +name: obsolete negative regulation of cellular hyperosmotic salinity response by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates cellular hyperosmotic salinity response." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100045 +name: negative regulation of arginine catabolic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any transcription from RNA polymerase II promoter process that negatively regulates arginine catabolic process." [GOC:cjm, GOC:obol] +is_a: GO:0006366 ! transcription by RNA polymerase II +relationship: negatively_regulates GO:0006527 ! arginine catabolic process + +[Term] +id: GO:0100046 +name: obsolete positive regulation of arginine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates arginine biosynthetic process." [GOC:cjm, GOC:obol] +comment: GO:0100046 +is_obsolete: true + +[Term] +id: GO:0100047 +name: obsolete negative regulation of inositol biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates inositol biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100048 +name: obsolete positive regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylcholine biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100049 +name: obsolete negative regulation of phosphatidylcholine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylcholine biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100050 +name: obsolete negative regulation of mating type switching by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates mating type switching." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100051 +name: obsolete positive regulation of meiotic nuclear division by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates meiotic nuclear division." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100052 +name: obsolete negative regulation of G1/S transition of mitotic cell cycle by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates G1/S transition of mitotic cell cycle." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100053 +name: obsolete positive regulation of sulfate assimilation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates sulfate assimilation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100054 +name: obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates flocculation via cell wall protein-carbohydrate interaction." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100055 +name: obsolete positive regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phosphatidylserine biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100056 +name: obsolete negative regulation of phosphatidylserine biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phosphatidylserine biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100057 +name: obsolete regulation of phenotypic switching by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates phenotypic switching." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100058 +name: obsolete positive regulation of phenotypic switching by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates phenotypic switching." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100059 +name: obsolete negative regulation of phenotypic switching by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates phenotypic switching." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100060 +name: obsolete negative regulation of SREBP signaling pathway by DNA binding +namespace: molecular_function +def: "OBSOLETE. Any DNA binding that negatively regulates SREBP signaling pathway." [GOC:cjm, GOC:obol] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100061 +name: obsolete negative regulation of SREBP signaling pathway by transcription factor catabolic process +namespace: biological_process +def: "OBSOLETE. Any transcription factor catabolic process process that negatively regulates SREBP signaling pathway." [GOC:cjm, GOC:obol] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100062 +name: obsolete positive regulation of SREBP signaling pathway by transcription factor catabolic process +namespace: biological_process +def: "OBSOLETE. Any transcription factor catabolic process process that positively_regulates SREBP signaling pathway." [GOC:cjm, GOC:obol] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100063 +name: obsolete regulation of dipeptide transmembrane transport by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates dipeptide transmembrane transport." [GOC:cjm, GOC:obol] +comment: The term was obsoleted because it is better represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100064 +name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates filamentous growth of a population of unicellular organisms in response to starvation." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100065 +name: obsolete negative regulation of leucine import by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates leucine import." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100066 +name: obsolete negative regulation of induction of conjugation with cellular fusion by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates induction of conjugation with cellular fusion." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100067 +name: positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway +namespace: biological_process +def: "Any canonical Wnt signaling pathway process that positively_regulates spinal cord association neuron differentiation." [GOC:cjm, GOC:obol] +is_a: GO:0060070 ! canonical Wnt signaling pathway +is_a: GO:1902831 ! positive regulation of spinal cord association neuron differentiation + +[Term] +id: GO:0100068 +name: obsolete positive regulation of pyrimidine-containing compound salvage by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that positively regulates pyrimidine-containing compound salvage." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100069 +name: obsolete negative regulation of neuron apoptotic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that negatively regulates neuron apoptotic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0100070 +name: obsolete obsolete regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any transcription from RNA polymerase II promoter process that regulates fatty acid biosynthetic process." [GOC:cjm, GOC:obol] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:0101002 +name: ficolin-1-rich granule +namespace: cellular_component +def: "Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry." [GOC:mec, PMID:19741154] +synonym: "ficolin granule" RELATED [] +synonym: "ficolin-1 rich granule" EXACT [] +is_a: GO:0030141 ! secretory granule + +[Term] +id: GO:0101003 +name: ficolin-1-rich granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a ficolin-1-rich granule." [GOC:mec, PMID:23650620] +is_a: GO:0030667 ! secretory granule membrane +relationship: part_of GO:0070820 ! tertiary granule +relationship: part_of GO:0101002 ! ficolin-1-rich granule + +[Term] +id: GO:0101004 +name: cytolytic granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding the cytolytic granule." [PMID:17272266, PMID:21247065] +is_a: GO:0005765 ! lysosomal membrane +relationship: part_of GO:0044194 ! cytolytic granule + +[Term] +id: GO:0101005 +name: deubiquitinase activity +namespace: molecular_function +alt_id: GO:1904265 +def: "Catalysis of the hydrolysis of ubiquitin from proteins." [GOC:mec] +comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. +synonym: "ubiquitinyl hydrolase activity" EXACT [] +xref: Reactome:R-HSA-9674127 "USP30 deubiquitinates ATM dimer:Ub-p-PEX5" +is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity + +[Term] +id: GO:0101006 +name: protein histidine phosphatase activity +namespace: molecular_function +alt_id: GO:0008969 +def: "Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate." [GOC:mec, RHEA:47964] +comment: This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- (RHEA:47964) and tele- (RHEA:47960) nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) (EC:3.9.1.3). +synonym: "phosphohistidine phosphatase activity" BROAD [] +xref: EC:3.9.1.3 +xref: RHEA:47964 +is_a: GO:0004721 ! phosphoprotein phosphatase activity +is_a: GO:0016825 ! hydrolase activity, acting on acid phosphorus-nitrogen bonds + +[Term] +id: GO:0101007 +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to salt stress +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0000122 +consider: GO:0071472 + +[Term] +id: GO:0101008 +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to increased salt +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mec] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0000122 +consider: GO:0071472 + +[Term] +id: GO:0101010 +name: pulmonary blood vessel remodeling +namespace: biological_process +def: "The reorganization or renovation of existing pulmonary blood vessels." [GOC:mec] +is_a: GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:0101011 +name: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate." [GOC:mah, PMID:26422458] +synonym: "inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity" EXACT [] +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0101012 +name: inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate + H2O = myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + phosphate." [GOC:mah, PMID:26422458] +synonym: "inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity" EXACT [] +is_a: GO:0052745 ! inositol phosphate phosphatase activity + +[Term] +id: GO:0101013 +name: mechanosensitive voltage-gated sodium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel whose activity is modulated in response to mechanical stress. Response to mechanical stress and voltage gating together is different than the sum of individual responses. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [PMID:21041530, PMID:26838316] +synonym: "mechanically-modulated voltage-gated sodium channel activity" EXACT [] +is_a: GO:0005248 ! voltage-gated sodium channel activity +is_a: GO:0140135 ! mechanosensitive cation channel activity + +[Term] +id: GO:0101014 +name: [isocitrate dehydrogenase (NADP+)] phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate." [PMID:6292732] +synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] +xref: MetaCyc:ICITDEHASE-KIN-PHOSPHA +is_a: GO:0004721 ! phosphoprotein phosphatase activity + +[Term] +id: GO:0101016 +name: FMN-binding domain binding +namespace: molecular_function +def: "Binding to the FMN-binding domain of a protein." [PMID:15752726] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0101017 +name: regulation of mitotic DNA replication initiation from late origin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] +synonym: "regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029] +is_a: GO:1903466 ! regulation of mitotic DNA replication initiation + +[Term] +id: GO:0101018 +name: negative regulation of mitotic DNA replication initiation from late origin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] +synonym: "negative regulation of late replication origin firing" EXACT [GOC:dph, GOC:krc, PMID:19221029] +is_a: GO:0101017 ! regulation of mitotic DNA replication initiation from late origin +is_a: GO:1903467 ! negative regulation of mitotic DNA replication initiation + +[Term] +id: GO:0101019 +name: nucleolar exosome (RNase complex) +namespace: cellular_component +def: "A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] +is_a: GO:0000176 ! nuclear exosome (RNase complex) +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0101020 +name: estrogen 16-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O." [GOC:BHF] +synonym: "oestrogen 16-alpha-hydroxylase activity" EXACT [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0101021 +name: estrogen 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O." [GOC:BHF, GOC:rl, PMID:14559847] +synonym: "oestrogen 2-hydroxylase activity" EXACT [] +is_a: GO:0008395 ! steroid hydroxylase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0101023 +name: vascular endothelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:23201774] +is_a: GO:0001935 ! endothelial cell proliferation + +[Term] +id: GO:0101024 +name: mitotic nuclear membrane organization +namespace: biological_process +def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis." [GOC:vw, PMID:15147872] +comment: This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. +synonym: "nuclear membrane organization involved in mitotic nuclear division" EXACT [] +is_a: GO:0071763 ! nuclear membrane organization +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0101025 +name: nuclear membrane biogenesis +namespace: biological_process +def: "The process in which a nuclear membrane is synthesized, aggregates, and bonds together." [GOC:vw] +is_a: GO:0044091 ! membrane biogenesis +relationship: part_of GO:0071763 ! nuclear membrane organization + +[Term] +id: GO:0101026 +name: mitotic nuclear membrane biogenesis +namespace: biological_process +def: "A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division." [GOC:vw, PMID:26869222] +synonym: "nuclear membrane biogenesis involved in mitotic nuclear division" EXACT [] +is_a: GO:0061024 ! membrane organization +is_a: GO:0101025 ! nuclear membrane biogenesis +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0140014 ! mitotic nuclear division + +[Term] +id: GO:0101027 +name: optical nerve axon regeneration +namespace: biological_process +def: "The regrowth of axons of the optical nerve following their loss or damage." [GOC:pga, PMID:16699509] +is_a: GO:0031103 ! axon regeneration + +[Term] +id: GO:0101028 +name: positive regulation of liquid surface tension +namespace: biological_process +def: "Any process that activates or increases the surface tension of a liquid." [GOC:sl, PMID:20949060] +synonym: "positive regulation of surface tension of a liquid" EXACT [] +is_a: GO:0050828 ! regulation of liquid surface tension + +[Term] +id: GO:0101029 +name: negative regulation of liquid surface tension +namespace: biological_process +def: "Any process that prevents or reduces the surface tension of a liquid." [GOC:sl, PMID:20949060] +synonym: "negative regulation of surface tension of a liquid" EXACT [] +is_a: GO:0050828 ! regulation of liquid surface tension + +[Term] +id: GO:0101030 +name: tRNA-guanine transglycosylation +namespace: biological_process +def: "The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine." [GOC:PomBase, GOC:vw, PMID:24911101] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0101031 +name: chaperone complex +namespace: cellular_component +def: "A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins." [GOC:bhm, PMID:21855797] +comment: An example of this is HSP90AB1 in human (P08238) in PMID:21855797 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0102001 +name: isoleucine N-monooxygenase (oxime forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.39] +xref: EC:1.14.14.39 +xref: MetaCyc:1.14.13.117-RXN +xref: RHEA:28602 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102002 +name: valine N-monooxygenase (oxime forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O." [EC:1.14.14.38] +xref: EC:1.14.14.38 +xref: MetaCyc:1.14.13.118-RXN +xref: RHEA:28606 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102003 +name: Delta8-sphingolipid desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.4] +xref: EC:1.14.19.4 +xref: MetaCyc:1.14.19.4-RXN +is_a: GO:0052631 ! sphingolipid delta-8 desaturase activity + +[Term] +id: GO:0102004 +name: 2-octaprenyl-6-hydroxyphenol methylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine." [EC:2.1.1.222] +xref: MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN +xref: RHEA:27770 +is_a: GO:1990888 ! 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity + +[Term] +id: GO:0102006 +name: 4-methyl-2-oxopentanoate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-] +xref: MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN +xref: RHEA:25177 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102007 +name: acyl-L-homoserine-lactone lactonohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine." [EC:3.1.1.81] +xref: EC:3.1.1.81 +xref: MetaCyc:3.1.1.81-RXN +xref: Reactome:R-HSA-8932633 "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE" +xref: RHEA:22576 +is_a: GO:0046573 ! lactonohydrolase activity + +[Term] +id: GO:0102009 +name: proline dipeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid." [EC:3.4.13.9] +xref: EC:3.4.13.9 +xref: MetaCyc:3.4.13.9-RXN +is_a: GO:0016805 ! dipeptidase activity + +[Term] +id: GO:0102013 +name: ATPase-coupled L-glutamate tranmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in)." [EC:7.4.2.1] +synonym: "L-glutamate-importing ATPase activity" RELATED [] +xref: MetaCyc:ABC-13-RXN +is_a: GO:0015426 ! ATPase-coupled polar amino acid-transporter activity + +[Term] +id: GO:0102014 +name: beta-D-galactose-importing ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+." [EC:3.6.3.17] +xref: MetaCyc:ABC-18-RXN +xref: RHEA:30011 +is_a: GO:0015407 ! ABC-type monosaccharide transporter activity + +[Term] +id: GO:0102025 +name: ABC-type thiosulfate transporter activity +namespace: molecular_function +alt_id: GO:0032146 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in)." [GOC:mlg, GOC:pz] +synonym: "ATPase-coupled thiosulfate transmembrane transporter activity" RELATED [] +synonym: "thiosulfate transmembrane-transporting ATPase activity" RELATED [] +synonym: "thiosulphate ABC transporter activity" EXACT [] +xref: EC:7.3.2.3 +xref: MetaCyc:ABC-7-RXN +xref: RHEA:29871 +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:0102027 +name: S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine." [GOC:pz, RHEA:30063] +xref: EC:2.1.1.163 +xref: MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN +xref: RHEA:30063 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102028 +name: cystathionine gamma-synthase activity (acts on O-phosphohomoserine) +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate." [GOC:pz, PMID:5922970, PMID:9531508] +xref: EC:2.5.1.48 +xref: MetaCyc:CYSPH-RXN +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102029 +name: D-lactate dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol." [GOC:pz, PMID:10944213, PMID:4575624, RHEA:51468] +xref: EC:1.1.5.12 +xref: MetaCyc:DLACTDEHYDROGFAD-RXN +xref: RHEA:51468 +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0102030 +name: dTDP-L-rhamnose synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+." [GOC:pz] +xref: MetaCyc:DTDPRHAMSYNTHMULTI-RXN +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102031 +name: 4-acetamido-4,6-dideoxy-D-galactose transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP." [EC:2.4.1.325, GOC:pz] +xref: EC:2.4.1.325 +xref: MetaCyc:FUC4NACTRANS-RXN +xref: RHEA:28759 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102033 +name: long-chain fatty acid omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:krc, PMID:18544608, RHEA:56748] +synonym: "cytochrome P450 fatty acid omega-hydroxylase activity" RELATED [] +xref: EC:1.14.14.80 +xref: MetaCyc:RXN-16394 +xref: RHEA:56748 +is_a: GO:0120250 ! fatty acid omega-hydroxylase activity + +[Term] +id: GO:0102035 +name: isobutyryl-CoA:FAD oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2." [GOC:pz, PMID:3988734] +xref: EC:1.3.8.5 +xref: MetaCyc:MEPROPCOA-FAD-RXN +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102036 +name: methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]." [EC:2.1.1.258, GOC:pz, PMID:7928975] +xref: EC:2.1.1.258 +xref: MetaCyc:METHCOCLTH-RXN +xref: RHEA:45200 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102037 +name: 4-nitrotoluene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O." [GOC:pz] +xref: MetaCyc:R361-RXN +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102038 +name: 4-nitrobenzyl alcohol oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide." [GOC:pz] +xref: MetaCyc:R362-RXN +is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor + +[Term] +id: GO:0102039 +name: alkylhydroperoxide reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide." [GOC:pz, PMID:12517450] +xref: EC:1.11.1.26 +xref: MetaCyc:R4-RXN +is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor + +[Term] +id: GO:0102040 +name: fumarate reductase (menaquinone) +namespace: molecular_function +def: "Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone." [GOC:pz, PMID:11850430, RHEA:27834] +xref: EC:1.3.5.4 +xref: MetaCyc:R601-RXN +xref: RHEA:27834 +is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor + +[Term] +id: GO:0102041 +name: 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase +namespace: molecular_function +def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid." [GOC:pz, RHEA:35951] +xref: EC:2.5.1.105 +xref: MetaCyc:RXN-10009 +xref: RHEA:35951 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102042 +name: dehydroquinate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+." [GOC:pz, RHEA:25956] +xref: EC:1.4.1.24 +xref: MetaCyc:RXN-10032 +xref: RHEA:25956 +is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102043 +name: isopentenyl phosphate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-)." [GOC:pz, PMID:19928876, RHEA:33963] +xref: EC:2.7.4.26 +xref: MetaCyc:RXN-10068 +xref: RHEA:33963 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0102044 +name: 3-chlorobenzoate-4,5-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz] +xref: MetaCyc:RXN-10421 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0102045 +name: 3-chlorobenzoate-3,4-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." [GOC:pz, PMID:8285670] +xref: MetaCyc:RXN-10422 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0102046 +name: 3,4-dichlorobenzoate-4,5-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor." [GOC:pz, PMID:9322760] +xref: MetaCyc:RXN-10427 +is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor + +[Term] +id: GO:0102047 +name: indole-3-acetyl-glycine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] +xref: MetaCyc:RXN-10429 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102048 +name: indole-3-acetyl-isoleucine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] +xref: MetaCyc:RXN-10430 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102049 +name: indole-3-acetyl-methionine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid." [GOC:pz, PMID:15659623] +xref: MetaCyc:RXN-10431 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102050 +name: indole-3-acetyl-tyrosine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10432 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102051 +name: indole-3-acetyl-tryptophan synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10433 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102052 +name: indole-3-acetyl-proline synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10434 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102053 +name: (-)-jasmonoyl-isoleucine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid." [GOC:pz] +xref: MetaCyc:RXN-10435 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102054 +name: maleylpyruvate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate." [GOC:pz, PMID:7400101, RHEA:47956] +xref: EC:3.7.1.23 +xref: MetaCyc:RXN-10447 +xref: RHEA:47956 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102055 +name: 12-hydroxyjasmonate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate." [GOC:pz, RHEA:52728] +xref: EC:2.8.2.39 +xref: MetaCyc:RXN-10451 +xref: RHEA:52728 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0102056 +name: 11-hydroxyjasmonate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate." [GOC:pz, RHEA:52732] +xref: EC:2.8.2.39 +xref: MetaCyc:RXN-10453 +xref: RHEA:52732 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0102057 +name: jasmonoyl-valine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine." [GOC:pz, PMID:17291501] +xref: EC:6.3.2.52 +xref: MetaCyc:RXN-10457 +xref: RHEA:55772 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102058 +name: jasmonoyl-leucine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine." [GOC:pz, PMID:17291501] +xref: EC:6.3.2.52 +xref: MetaCyc:RXN-10459 +xref: RHEA:55772 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102059 +name: 2-cis,6-cis-farnesyl pyrophosphate synthase activity +namespace: molecular_function +alt_id: GO:0102192 +def: "Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate." [GOC:pz, RHEA:27810] +synonym: "neryl-diphosphate:isopentenyl-diphosphate cistransferase activity" NARROW [] +xref: EC:2.5.1.92 +xref: MetaCyc:RXN-10481 +xref: MetaCyc:RXN-11973 +xref: RHEA:27810 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102060 +name: endo-alpha-bergamotene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid." [GOC:pz, RHEA:30471] +synonym: "endo-alpha-bergamontene synthase activity" EXACT [] +xref: EC:4.2.3.54 +xref: MetaCyc:RXN-10482 +xref: RHEA:30471 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102061 +name: endo-beta-bergamotene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid." [GOC:pz, RHEA:30467] +synonym: "(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing)" EXACT [EC:4.2.3.53] +synonym: "(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene" EXACT [EC:4.2.3.53] +synonym: "endo-beta-bergamontene synthase activity" EXACT [] +xref: EC:4.2.3.53 +xref: MetaCyc:RXN-10483 +xref: RHEA:30467 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102062 +name: alpha-santalene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid." [EC:4.2.3.50, GOC:pz] +xref: EC:4.2.3.50 +xref: MetaCyc:RXN-10567 +xref: RHEA:30463 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102063 +name: beta-curcumene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-10598 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102064 +name: gamma-curcumene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid." [EC:4.2.3.94, GOC:pz] +xref: EC:4.2.3.94 +xref: MetaCyc:RXN-10599 +xref: RHEA:32031 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102065 +name: patchoulene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-10602 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102066 +name: alpha-patchoulene synthase activityy +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-10603 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102067 +name: geranylgeranyl diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+." [EC:1.3.1.83, GOC:pz] +xref: EC:1.3.1.83 +xref: MetaCyc:RXN-10625 +xref: RHEA:26229 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102068 +name: alpha-humulene 10-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O." [EC:1.14.14.113, GOC:pz] +xref: EC:1.14.14.113 +xref: MetaCyc:RXN-10628 +xref: RHEA:32491 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102069 +name: zerumbone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+." [EC:1.1.1.326, GOC:pz] +xref: EC:1.1.1.326 +xref: MetaCyc:RXN-10629 +xref: RHEA:32327 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102070 +name: 18-hydroxyoleate peroxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol." [GOC:pz, PMID:12226220, PMID:14535881, PMID:468835] +xref: EC:1.11.2.3 +xref: MetaCyc:RXN-1064 +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0102071 +name: 9,10-epoxy-18-hydroxystearate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate." [EC:3.3.2.-, GOC:pz] +xref: MetaCyc:RXN-1065 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0102072 +name: obsolete 3-oxo-cis-Delta9-hexadecenoyl-[acp] reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxy cis Delta9-hexadecenoyl-[acp] <=> NADPH + H+ + a 3-oxo-cis-Delta9-hexadecenoyl-[acp]." [GOC:pz] +comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO. +is_obsolete: true +consider: GO:0004316 + +[Term] +id: GO:0102073 +name: OPC8-trans-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA <=> OPC8-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz] +xref: MetaCyc:RXN-10697 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102074 +name: OPC6-trans-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA <=> OPC6-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz] +xref: MetaCyc:RXN-10704 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102075 +name: OPC4-trans-2-enoyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA <=> OPC4-trans-2-enoyl-CoA + H2O." [EC:4.2.1.17, GOC:pz] +xref: MetaCyc:RXN-10705 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102076 +name: beta,beta-carotene-9',10'-cleaving oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone." [EC:1.13.11.71, GOC:pz] +xref: EC:1.13.11.71 +xref: MetaCyc:RXN-10741 +xref: RHEA:26389 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102077 +name: oleamide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleamide + H2O <=> oleate + ammonium." [EC:3.5.1.99, GOC:pz] +xref: EC:3.5.1.99 +xref: MetaCyc:RXN-10756 +xref: RHEA:26506 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0102080 +name: phenylacetyl-coenzyme A:glycine N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A." [EC:2.3.1.192, GOC:pz] +xref: EC:2.3.1.192 +xref: MetaCyc:RXN-10821 +xref: RHEA:27850 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102081 +name: homotaurine:2-oxoglutarate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-)." [EC:2.6.1.-, GOC:pz] +xref: MetaCyc:RXN-10822 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0102082 +name: demethylrebeccamycin--D-glucose O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine." [EC:2.1.1.164, GOC:pz] +xref: EC:2.1.1.164 +xref: MetaCyc:RXN-10847 +xref: RHEA:27353 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102083 +name: 7,8-dihydromonapterin aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol." [GOC:pz, PMID:15107504] +xref: MetaCyc:RXN-10857 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0102084 +name: L-dopa O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.6, GOC:pz] +xref: EC:2.1.1.6 +xref: MetaCyc:RXN-10870 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102085 +name: N-(4-aminobenzoyl)-L-glutamate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10884 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102086 +name: N-vanillate-L-glutamate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10885 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102087 +name: N-benzoyl-L-glutamate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10886 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102088 +name: N-(4-hydroxybenzoyl)-L-glutamate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-10887 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102089 +name: dehydroscoulerine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+." [EC:1.21.3.-, GOC:pz] +xref: MetaCyc:RXN-10888 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0102090 +name: adrenaline O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.6, GOC:pz] +xref: MetaCyc:RXN-10909 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102091 +name: phosphatidylinositol-5-phosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = hydrogenphosphate + an L-1-phosphatidyl-inositol." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN-10962 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0102092 +name: 5-diphosphoinositol pentakisphosphate 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP." [EC:2.7.4.24, GOC:pz] +xref: EC:2.7.4.24 +xref: MetaCyc:RXN-10979 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0102093 +name: acrylate:acyl-coA CoA transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-10985 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102094 +name: S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol." [GOC:pz, PMID:1444716, PMID:9045837, RHEA:26466] +xref: EC:2.1.1.163 +xref: MetaCyc:RXN-11046 +xref: RHEA:26466 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102096 +name: decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+." [EC:2.4.1.289, GOC:pz] +xref: EC:2.4.1.289 +xref: MetaCyc:RXN-11070 +xref: RHEA:34487 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102097 +name: (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O." [GOC:pz, RHEA:27325] +xref: EC:1.14.14.147 +xref: MetaCyc:RXN-11101 +xref: RHEA:27325 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102098 +name: D-galacturonate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+." [EC:1.1.1.365, GOC:pz] +xref: EC:1.1.1.365 +xref: MetaCyc:RXN-11151 +xref: RHEA:26345 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102099 +name: FAD-dependent urate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O." [EC:1.14.13.113, GOC:pz] +xref: EC:1.14.13.113 +xref: MetaCyc:RXN-11186 +xref: RHEA:27329 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102100 +name: mycothiol-arsenate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O." [EC:2.8.4.2, GOC:pz] +xref: EC:2.8.4.2 +xref: MetaCyc:RXN-11187 +xref: RHEA:27349 +is_a: GO:0050497 ! alkylthioltransferase activity + +[Term] +id: GO:0102102 +name: homocarnosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate." [EC:6.3.2.11, GOC:pz] +xref: EC:6.3.2.11 +xref: MetaCyc:RXN-11222 +xref: RHEA:59568 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0102103 +name: demethoxycurcumin synthase +namespace: molecular_function +def: "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide." [EC:2.3.1.219, GOC:pz] +xref: EC:2.3.1.219 +xref: MetaCyc:RXN-11223 +xref: RHEA:35119 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102104 +name: demethoxycurcumin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-11224 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102105 +name: demethoxycurcumin synthase activity from feruloylacetyl-CoA +namespace: molecular_function +def: "Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide." [GOC:pz, RHEA:35139] +xref: EC:2.3.1.219 +xref: MetaCyc:RXN-11225 +xref: RHEA:35139 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102106 +name: curcumin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide." [EC:2.3.1.217, GOC:pz] +xref: EC:2.3.1.217 +xref: MetaCyc:RXN-11226 +xref: RHEA:34823 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102109 +name: tricaffeoyl spermidine O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine." [GOC:pz, PMID:19077165] +xref: MetaCyc:RXN-11261 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102111 +name: gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-113 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102113 +name: hypoxia-inducible factor-asparagine oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + O2 + a hypoxia inducible factor (HIF) alpha subunit = succinate + carbon dioxide + a (3S)-3-hydroxy-L-asparagine-HIF alpha subunit." [GOC:pz, RHEA:54268] +xref: EC:1.14.11.30 +xref: MetaCyc:RXN-11321 +xref: RHEA:54268 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102114 +name: caprate dehydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: decanoate + NADPH + O2 + H+ <=> 10-hydroxycaprate + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11325 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102115 +name: peptidoglycan asparagine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid." [EC:6.3.1.-, GOC:pz] +xref: MetaCyc:RXN-11338 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0102116 +name: laurate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11340 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102117 +name: gibberellin A9 carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.275, GOC:pz] +xref: EC:2.1.1.275 +xref: MetaCyc:RXN-11358 +xref: RHEA:36119 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102118 +name: gibberellin A4 carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.276, GOC:pz] +xref: EC:2.1.1.276 +xref: MetaCyc:RXN-11359 +xref: RHEA:36107 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102119 +name: gibberellin A20 carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11360 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102121 +name: ceramidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid." [EC:3.5.1.23, GOC:pz] +xref: EC:3.5.1.23 +xref: MetaCyc:RXN-11375 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0102122 +name: gibberellin A34 carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz, RHEA:36127] +xref: MetaCyc:RXN-11384 +xref: RHEA:36127 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102123 +name: gibberellin A4 16alpha,17 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P)." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-11385 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102124 +name: gibberellin A12 16alpha,17 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P)." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-11387 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102125 +name: gibberellin A9 16alpha,17 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P)." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-11388 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102126 +name: coniferyl aldehyde 5-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-1142 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102127 +name: 8-oxoguanine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium." [EC:3.5.4.32, GOC:pz] +xref: EC:3.5.4.32 +xref: MetaCyc:RXN-11455 +xref: RHEA:32067 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0102128 +name: chalcone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide." [GOC:pz, PMID:20356611] +xref: EC:2.3.1.74 +xref: MetaCyc:RXN-11468 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102130 +name: malonyl-CoA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester." [GOC:pz, RHEA:17105] +xref: EC:2.1.1.197 +xref: MetaCyc:RXN-11475 +xref: RHEA:17105 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102131 +name: obsolete 3-oxo-glutaryl-[acp] methyl ester reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxyglutaryl-[acp] methyl ester <=> NADPH + H+ + a 3-oxo-glutaryl-[acp] methyl ester." [GOC:pz] +comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO. +is_obsolete: true +consider: GO:0004316 + +[Term] +id: GO:0102132 +name: obsolete 3-oxo-pimeloyl-[acp] methyl ester reductase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: NADP + a 3R-hydroxypimeloyl-[acp] methyl ester <=> NADPH + H+ + a 3-oxo-pimeloyl-[acp] methyl ester." [GOC:pz] +comment: This term was obsoleted because it represents a specific substrate, and is beyond the specificity of GO. +is_obsolete: true +consider: GO:0004316 + +[Term] +id: GO:0102133 +name: limonene hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11493 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102134 +name: (22S)-22-hydroxy-campesterol C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O." [GOC:pz] +xref: MetaCyc:RXN-11529 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102135 +name: (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O." [GOC:pz] +xref: MetaCyc:RXN-11530 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102136 +name: 3-epi-6-deoxocathasterone C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O." [GOC:pz, PMID:17138693, RHEA:27321] +xref: EC:1.14.14.147 +xref: MetaCyc:RXN-11531 +xref: RHEA:27321 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102137 +name: 7-oxateasterone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11537 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102138 +name: 7-oxatyphasterol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11538 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102139 +name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate." [EC:3.7.1.13, GOC:pz] +xref: EC:3.7.1.13 +xref: MetaCyc:RXN-11543 +xref: RHEA:27870 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102140 +name: heparan sulfate N-deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine." [EC:3.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11557 +is_a: GO:0019213 ! deacetylase activity +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102141 +name: [chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate." [EC:2.8.2.-, GOC:pz] +xref: MetaCyc:RXN-11560 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0102142 +name: [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate." [EC:2.8.2.-, GOC:pz] +xref: MetaCyc:RXN-11561 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0102143 +name: carboxynorspermidine dehydrogenase I activity +namespace: molecular_function +def: "Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+." [EC:1.5.1.43, GOC:pz] +xref: MetaCyc:RXN-11565 +xref: RHEA:34115 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102144 +name: carboxyspermidine dehydrogenase II activity +namespace: molecular_function +def: "Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+." [EC:1.5.1.43, GOC:pz] +xref: MetaCyc:RXN-11566 +xref: RHEA:34111 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102145 +name: (3R)-(E)-nerolidol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid." [GOC:pz, RHEA:27534] +xref: EC:4.2.3.49 +xref: MetaCyc:RXN-11575 +xref: RHEA:27534 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102146 +name: tricetin O-methytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine." [GOC:pz, RHEA:27493] +xref: MetaCyc:RXN-11582 +xref: RHEA:27493 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102147 +name: 3'-O-methyltricetin O methyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11583 +xref: RHEA:27497 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102148 +name: N-acetyl-beta-D-galactosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan." [EC:3.2.1.52, GOC:pz] +xref: EC:3.2.1.52 +xref: MetaCyc:RXN-11622 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102149 +name: farnesylcysteine lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide." [EC:1.8.3.6, GOC:pz] +xref: EC:1.8.3.6 +xref: MetaCyc:RXN-11623 +xref: RHEA:30231 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0102150 +name: 3-oxo-myristoyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+." [EC:3.1.2.-, GOC:pz] +xref: MetaCyc:RXN-11668 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102151 +name: 3-oxo-myristate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide." [EC:4.1.1.56, GOC:pz] +xref: EC:4.1.1.56 +xref: MetaCyc:RXN-11669 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0102152 +name: Delta12-linoleate epoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11671 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102154 +name: 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-11685 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102155 +name: S-sulfolactate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+." [EC:1.1.1.310, GOC:pz] +xref: EC:1.1.1.310 +xref: MetaCyc:RXN-11689 +xref: RHEA:28194 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102156 +name: 2,5-DHBA UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-11705 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102157 +name: (R)-sulfopropanediol 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+." [GOC:pz, PMID:20150239] +xref: MetaCyc:RXN-11729 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102158 +name: very-long-chain 3-hydroxyacyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain trans-2,3-dehydroacyl-CoA." [GOC:pz, RHEA:45812] +xref: EC:4.2.1.134 +xref: MetaCyc:RXN-11750 +xref: RHEA:45812 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102159 +name: baicalein 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin." [EC:2.4.1.253, GOC:pz] +xref: EC:2.4.1.253 +xref: MetaCyc:RXN-11755 +xref: RHEA:28314 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102160 +name: cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP." [EC:2.4.1.254, GOC:pz] +xref: EC:2.4.1.254 +xref: MetaCyc:RXN-11756 +xref: RHEA:28258 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102161 +name: copal-8-ol diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O." [EC:4.2.1.133, GOC:pz] +xref: EC:4.2.1.133 +xref: MetaCyc:RXN-11772 +xref: RHEA:32703 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102162 +name: all-trans-8'-apo-beta-carotenal 15,15'-oxygenase +namespace: molecular_function +def: "Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial." [EC:1.13.11.75, GOC:pz] +xref: EC:1.13.11.75 +xref: MetaCyc:RXN-11783 +xref: RHEA:26385 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102163 +name: 3-hydroxyacyl-CoA-acyl carrier protein transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-11785 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102164 +name: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O." [EC:1.14.13.182, GOC:pz] +xref: EC:1.14.13.182 +xref: MetaCyc:RXN-11849 +xref: RHEA:37871 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102165 +name: (Z)-3-hexen-1-ol acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A." [GOC:pz, RHEA:28254] +xref: EC:2.3.1.195 +xref: MetaCyc:RXN-11852 +xref: RHEA:28254 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102166 +name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine." [EC:3.2.1.169, GOC:pz] +xref: EC:3.2.1.169 +xref: MetaCyc:RXN-11891 +xref: RHEA:48892 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102167 +name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine." [EC:3.2.1.169, GOC:pz] +xref: EC:3.2.1.169 +xref: MetaCyc:RXN-11892 +xref: RHEA:48876 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102168 +name: 5-methyl-phenazine-1-carboxylate N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11897 +xref: RHEA:49112 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102169 +name: pyocyanin hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ = pyocyanin + NAD + carbon dioxide + H2O." [GOC:pz, PMID:11591691] +xref: EC:1.14.13.218 +xref: MetaCyc:RXN-11898 +xref: RHEA:48976 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102170 +name: 5-epi-aristolochene-1,3-dihydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O." [EC:1.14.14.149, GOC:pz] +xref: EC:1.14.14.149 +xref: MetaCyc:RXN-11908 +xref: RHEA:28226 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102171 +name: DMNT synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11911 +xref: RHEA:55424 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102172 +name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11925 +xref: RHEA:58860 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102173 +name: 24-methylenecycloartanol 4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11926 +xref: RHEA:58836 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102174 +name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11927 +xref: RHEA:58864 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102175 +name: 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH." [GOC:pz, RHEA:34775] +xref: MetaCyc:RXN-11928 +xref: RHEA:34775 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102176 +name: cycloeucalenone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cycloeucalenone + NADPH + H+ <=> cycloeucalenol + NADP." [GOC:pz, PMID:4387005] +xref: EC:1.1.1.270 +xref: MetaCyc:RXN-11929 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102177 +name: 24-methylenelophenol methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [GOC:pz, PMID:11707264, RHEA:58872] +xref: EC:1.14.18.11 +xref: MetaCyc:RXN-11930 +xref: RHEA:58872 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102178 +name: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11932 +xref: RHEA:58880 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102179 +name: 24-ethylidenelophenol 4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11935 +xref: RHEA:59032 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102180 +name: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11936 +xref: RHEA:59036 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102181 +name: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11937 +xref: RHEA:59040 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102182 +name: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11938 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102183 +name: avenastenone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: avenastenone + NADPH + H+ <=> avenasterol + NADP." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11939 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102184 +name: cycloartenol 4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11946 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102185 +name: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11947 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102186 +name: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11948 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102187 +name: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) <=> 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-11949 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102188 +name: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11956 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102189 +name: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11957 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102190 +name: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-11958 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102191 +name: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide." [GOC:pz, RHEA:59016] +xref: EC:1.1.1.418 +xref: MetaCyc:RXN-11959 +xref: RHEA:59016 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102193 +name: protein-ribulosamine 3-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine." [EC:2.7.1.172, GOC:pz] +xref: EC:2.7.1.172 +xref: MetaCyc:RXN-12003 +xref: RHEA:48432 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0102194 +name: protein-fructosamine 3-kinase activity +namespace: molecular_function +alt_id: GO:0030387 +def: "Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine." [EC:2.7.1.171, GOC:pz, PMID:11016445] +synonym: "fructosamine-3-kinase activity" RELATED [] +xref: EC:2.7.1.171 +xref: MetaCyc:RXN-12005 +xref: RHEA:59832 +is_a: GO:0016301 ! kinase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0102195 +name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+." [EC:6.3.2.37, GOC:pz] +xref: EC:6.3.2.37 +xref: MetaCyc:RXN-12042 +xref: RHEA:25273 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0102196 +name: cortisol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+." [GOC:pz, PMID:16216911] +xref: EC:1.1.1.146 +xref: MetaCyc:RXN-12085 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102197 +name: vinylacetate caboxylester hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate." [GOC:pz, PMID:19555778] +xref: MetaCyc:RXN-12087 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102198 +name: L-idonate 5-dehydrogenase activity (NAD-dependent) +namespace: molecular_function +def: "Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+." [GOC:pz, RHEA:21172] +xref: EC:1.1.1.366 +xref: MetaCyc:RXN-12107 +xref: RHEA:21172 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102199 +name: nitric oxide reductase activity (NAD(P)H-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H." [EC:1.7.1.14, GOC:pz] +xref: EC:1.7.1.14 +xref: MetaCyc:RXN-12112 +is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor + +[Term] +id: GO:0102200 +name: N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate." [GOC:pz, RHEA:33159] +xref: EC:3.1.4.54 +xref: MetaCyc:RXN-12116 +xref: RHEA:33159 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0102201 +name: (+)-2-epi-prezizaene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid." [GOC:pz, PMID:20175559, PMID:20201526] +xref: MetaCyc:RXN-12117 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102202 +name: soladodine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+." [EC:2.4.1.173, GOC:pz, RHEA:61844] +xref: EC:2.4.1.173 +xref: MetaCyc:RXN-12123 +xref: RHEA:61844 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102203 +name: brassicasterol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+." [EC:2.4.1.173, GOC:pz, RHEA:61840] +xref: EC:2.4.1.173 +xref: MetaCyc:RXN-12125 +xref: RHEA:61840 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102205 +name: cholesterol alpha-glucosyltransferase activity +namespace: molecular_function +alt_id: GO:0051505 +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+." [GOC:pz, RHEA:61848] +synonym: "cholesterol allpha-glucosyltransferase activity" EXACT [] +synonym: "cholesterol UDP-glucosyltransferase activity" RELATED [] +xref: EC:2.4.1.173 +xref: MetaCyc:RXN-12127 +xref: RHEA:61848 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102207 +name: docosanoate omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:krc, GOC:pz, RHEA:40079] +synonym: "behenate omega-hydroxylase activity" EXACT [] +xref: MetaCyc:RXN-12155 +xref: RHEA:40079 +is_a: GO:0120250 ! fatty acid omega-hydroxylase activity + +[Term] +id: GO:0102208 +name: 2-polyprenyl-6-hydroxyphenol methylase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol." [EC:2.1.1.222, GOC:pz] +xref: MetaCyc:RXN-12160 +xref: RHEA:31411 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102209 +name: trans-permethrin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate." [EC:3.1.1.88, GOC:pz] +xref: EC:3.1.1.88 +xref: MetaCyc:RXN-12167 +xref: RHEA:30283 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102210 +name: rhamnogalacturonan endolyase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]." [EC:4.2.2.23, GOC:pz] +xref: EC:4.2.2.23 +xref: MetaCyc:RXN-12173 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0102211 +name: unsaturated rhamnogalacturonyl hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose." [EC:3.2.1.172, GOC:pz] +xref: EC:3.2.1.172 +xref: MetaCyc:RXN-12174 +xref: RHEA:30927 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102212 +name: unsaturated chondroitin disaccharide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate." [EC:3.2.1.180, GOC:pz] +xref: EC:3.2.1.180 +xref: MetaCyc:RXN-12177 +xref: RHEA:31647 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102213 +name: in-chain hydroxy fatty acyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12184 +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0102214 +name: omega-hydroxy fatty acyl-CoA synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12185 +is_a: GO:0015645 ! fatty acid ligase activity +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0102215 +name: thiocyanate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-12189 +xref: RHEA:28014 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102216 +name: maltodextrin water dikinase +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin." [EC:2.7.9.4, GOC:pz] +xref: EC:2.7.9.4 +xref: MetaCyc:RXN-12201 +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0102217 +name: 6-phosphoglucan, water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin." [GOC:pz, RHEA:10256] +xref: EC:2.7.9.5 +xref: MetaCyc:RXN-12202 +xref: RHEA:10256 +is_a: GO:0016781 ! phosphotransferase activity, paired acceptors + +[Term] +id: GO:0102218 +name: starch, H2O dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin." [EC:2.7.9.4, GOC:pz] +xref: EC:2.7.9.4 +xref: MetaCyc:RXN-12203 +is_a: GO:0050521 ! alpha-glucan, water dikinase activity + +[Term] +id: GO:0102219 +name: phosphogluco-amylopectin water dikinase activity +namespace: molecular_function +def: "Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin." [EC:2.7.9.5, GOC:pz] +xref: EC:2.7.9.5 +xref: MetaCyc:RXN-12204 +is_a: GO:0051752 ! phosphoglucan, water dikinase activity + +[Term] +id: GO:0102220 +name: hydrogenase activity (NAD+, ferredoxin) +namespace: molecular_function +def: "Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin." [GOC:pz, RHEA:30279] +xref: EC:1.12.1.4 +xref: MetaCyc:RXN-12215 +xref: RHEA:30279 +is_a: GO:0016696 ! oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor + +[Term] +id: GO:0102222 +name: obsolete 6-phosophogluco-3-phosphogluco-starch phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: m+q H2O + a 6-phosphogluco-3-phosphogluco-amylopectin <=> m+q hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin." [GOC:pz] +comment: This term was obsoleted because it was created by error. +xref: MetaCyc:RXN-12218 +is_obsolete: true + +[Term] +id: GO:0102223 +name: 4,4'-diapophytoene desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2." [EC:1.3.8.2, GOC:pz] +xref: EC:1.3.8.2 +xref: MetaCyc:RXN-12224 +xref: RHEA:31391 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102224 +name: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12236 +xref: RHEA:46316 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102225 +name: 4,4'-diaponeurosporene desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2." [EC:1.3.8.-, GOC:pz] +xref: MetaCyc:RXN-12258 +xref: RHEA:31407 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102229 +name: amylopectin maltohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose." [EC:3.2.1.2, GOC:pz] +xref: EC:3.2.1.2 +xref: MetaCyc:RXN-12278 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102232 +name: acrolein reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP." [GOC:pz, PMID:21169366] +xref: MetaCyc:RXN-12281 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102233 +name: crotonaldehyde redutase activity +namespace: molecular_function +def: "Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12292 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102234 +name: but-1-en-3-one reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12293 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102235 +name: 1-penten-3-one reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP." [GOC:pz] +xref: MetaCyc:RXN-12295 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102236 +name: trans-4-hexen-3-one reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP." [GOC:pz, PMID:21169366] +xref: MetaCyc:RXN-12296 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102237 +name: ATP:farnesol kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+." [GOC:pz, RHEA:61656] +synonym: "ATP-dependent farnesol kinase activity" RELATED [] +xref: MetaCyc:RXN-12304 +xref: RHEA:61656 +is_a: GO:0052673 ! prenol kinase activity + +[Term] +id: GO:0102238 +name: geraniol kinase activity (ATP-dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+." [EC:2.7.1.-, GOC:pz] +xref: MetaCyc:RXN-12307 +is_a: GO:0052670 ! geraniol kinase activity + +[Term] +id: GO:0102240 +name: soyasapogenol B glucuronide galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III." [EC:2.4.1.272, GOC:pz] +xref: EC:2.4.1.272 +xref: MetaCyc:RXN-12319 +xref: RHEA:31487 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102241 +name: soyasaponin III rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I." [EC:2.4.1.273, GOC:pz] +xref: EC:2.4.1.273 +xref: MetaCyc:RXN-12320 +xref: RHEA:31491 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102243 +name: ATP:geranylgeraniol phosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP." [GOC:pz, RHEA:61660] +xref: EC:2.7.1.216 +xref: MetaCyc:RXN-12325 +xref: RHEA:61660 +is_a: GO:0052671 ! geranylgeraniol kinase activity + +[Term] +id: GO:0102244 +name: 3-aminopropanal dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH." [EC:1.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12332 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102245 +name: lupan-3beta,20-diol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O." [EC:4.2.1.128, GOC:pz] +xref: EC:4.2.1.128 +xref: MetaCyc:RXN-12338 +xref: RHEA:31351 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102246 +name: 6-amino-6-deoxyfutalosine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine." [EC:3.2.2.30, GOC:pz] +xref: EC:3.2.2.30 +xref: MetaCyc:RXN-12346 +xref: RHEA:33079 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0102247 +name: malonyl-malonyl acyl carrier protein-condensing enzyme activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12361 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102248 +name: diacylglycerol transacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12383 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102249 +name: phosphatidylcholine:diacylglycerol cholinephosphotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine." [EC:2.7.8.-, GOC:pz] +xref: MetaCyc:RXN-12386 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0102250 +name: linear malto-oligosaccharide phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide." [EC:2.4.1.1, GOC:pz] +xref: EC:2.4.1.1 +xref: MetaCyc:RXN-12392 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102251 +name: all-trans-beta-apo-10'-carotenal cleavage oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial." [EC:1.13.11.70, GOC:pz] +xref: EC:1.13.11.70 +xref: MetaCyc:RXN-12393 +xref: RHEA:26401 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102252 +name: cellulose 1,4-beta-cellobiosidase activity (reducing end) +namespace: molecular_function +def: "Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains." [EC:3.2.1.176, GOC:pz] +xref: EC:3.2.1.176 +xref: MetaCyc:RXN-12420 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102253 +name: neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside." [EC:3.2.1.159, GOC:pz] +xref: EC:3.2.1.159 +xref: MetaCyc:RXN-12426 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102254 +name: neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose." [EC:3.2.1.159, GOC:pz] +xref: EC:3.2.1.159 +xref: MetaCyc:RXN-12427 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102255 +name: neo-lambda-carrahexaose hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose." [EC:3.2.1.162, GOC:pz] +xref: EC:3.2.1.162 +xref: MetaCyc:RXN-12428 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102256 +name: neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose." [EC:3.2.1.159, GOC:pz] +xref: EC:3.2.1.159 +xref: MetaCyc:RXN-12429 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102257 +name: 1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+." [EC:3.1.1.32, GOC:pz] +xref: MetaCyc:RXN-12430 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102258 +name: 1,3-diacylglycerol acylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid." [GOC:pz, PMID:21477884] +xref: MetaCyc:RXN-12433 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102259 +name: 1,2-diacylglycerol acylhydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid." [GOC:pz, PMID:1477884] +xref: MetaCyc:RXN-12434 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102261 +name: 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420." [EC:1.5.1.40, GOC:pz] +xref: EC:1.5.1.40 +xref: MetaCyc:RXN-12450 +xref: RHEA:31363 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102262 +name: tRNA-dihydrouridine16 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) <=> H+ + a uracil16 in tRNA + NAD(P)H." [EC:1.3.1.88, GOC:pz] +xref: MetaCyc:RXN-12454 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102263 +name: tRNA-dihydrouridine17 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) <=> H+ + a uracil17 in tRNA + NAD(P)H." [EC:1.3.1.88, GOC:pz] +xref: EC:1.3.1.88 +xref: MetaCyc:RXN-12455 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102264 +name: tRNA-dihydrouridine20 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) <=> H+ + a uracil20 in tRNA + NAD(P)H." [EC:1.3.1.91, GOC:pz] +xref: EC:1.3.1.91 +xref: MetaCyc:RXN-12456 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102265 +name: tRNA-dihydrouridine47 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H." [EC:1.3.1.89, GOC:pz] +xref: EC:1.3.1.89 +xref: MetaCyc:RXN-12457 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102266 +name: tRNA-dihydrouridine20a synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) <=> H+ + a uracil20a in tRNA + NAD(P)H." [EC:1.3.1.90, GOC:pz] +xref: EC:1.3.1.90 +xref: MetaCyc:RXN-12475 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102267 +name: tRNA-dihydrouridine20b synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) <=> H+ + a uracil20b in tRNA + NAD(P)H." [EC:1.3.1.90, GOC:pz] +xref: MetaCyc:RXN-12476 +is_a: GO:0017150 ! tRNA dihydrouridine synthase activity + +[Term] +id: GO:0102272 +name: homophytochelatin synthase activity (polymer-forming) +namespace: molecular_function +def: "Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine." [EC:2.3.2.-, GOC:pz] +xref: MetaCyc:RXN-12528 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0102273 +name: homophytochelatin synthase (dimmer forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine." [EC:2.3.2.-, GOC:pz] +xref: MetaCyc:RXN-12529 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0102274 +name: glutathione S-conjugate carboxypeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate." [EC:3.4.17.-, GOC:pz] +xref: MetaCyc:RXN-12532 +is_a: GO:0004181 ! metallocarboxypeptidase activity + +[Term] +id: GO:0102275 +name: cysteine-S-conjugate N-malonyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12534 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102276 +name: 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O." [EC:1.13.12.19, GOC:pz] +xref: EC:1.13.12.19 +xref: MetaCyc:RXN-12538 +xref: RHEA:31523 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0102277 +name: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12544 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102278 +name: N,N'-diacetylchitobiose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-12554 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102279 +name: lecithin:11-cis retinol acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine." [EC:2.3.1.135, GOC:pz] +xref: EC:2.3.1.135 +xref: MetaCyc:RXN-12563 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102280 +name: choline monooxygenase activity (NADP-dependent) +namespace: molecular_function +def: "Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-12582 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102281 +name: formylaminopyrimidine deformylase activity +namespace: molecular_function +def: "Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate." [EC:3.5.1.-, GOC:pz] +xref: MetaCyc:RXN-12612 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0102282 +name: 3-ketodihydrosphinganine (C18) reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(1-) + a sphinganine <=> 3-dehydrosphinganinium(1+) + NADH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-12641 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102283 +name: 3-ketodihydrosphinganine (C20) reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: C20 sphinganine(1+) + NADP <=> C20 3-dehydrosphinganine(1+) + NADPH + H+." [EC:1.1.1.102, GOC:pz] +xref: MetaCyc:RXN-12642 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102284 +name: L-threo-sphinganine reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-threo-sphinganine + NADP <=> H+ + NADPH + 3-dehydrosphinganinium(1+)." [EC:1.1.1.102, GOC:pz] +xref: MetaCyc:RXN-12645 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102285 +name: 1-deoxy-11-oxopentalenate oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP." [GOC:pz, RHEA:34635] +xref: EC:1.14.13.170 +xref: MetaCyc:RXN-12654 +xref: RHEA:34635 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102286 +name: ornithine N-delta-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12667 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102287 +name: 4-coumaroylhexanoylmethane synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12668 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102289 +name: beta-amyrin 11-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP." [EC:1.14.14.152, GOC:pz] +xref: EC:1.14.14.152 +xref: MetaCyc:RXN-12680 +xref: RHEA:31711 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102290 +name: beta-amyrin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP." [EC:1.14.14.152, GOC:pz] +xref: EC:1.14.14.152 +xref: MetaCyc:RXN-12681 +xref: RHEA:31715 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102291 +name: 11alpha-hydroxy-beta-amyrin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP." [GOC:pz, RHEA:31719] +xref: EC:1.14.14.152 +xref: MetaCyc:RXN-12682 +xref: RHEA:31719 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102292 +name: 30-hydroxy-beta-amyrin 11-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-12683 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102293 +name: pheophytinase b activity +namespace: molecular_function +def: "Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol." [EC:3.1.1.14, GOC:pz] +xref: EC:3.1.1.14 +xref: MetaCyc:RXN-12686 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102294 +name: cholesterol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+." [GOC:pz, RHEA:35459] +xref: EC:1.1.1.145 +xref: MetaCyc:RXN-12693 +xref: RHEA:35459 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102295 +name: 4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12699 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102296 +name: 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+." [EC:3.7.1.17, GOC:pz] +xref: EC:3.7.1.17 +xref: MetaCyc:RXN-12718 +xref: RHEA:32035 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102297 +name: selenate adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid." [EC:2.7.7.4, GOC:pz] +xref: MetaCyc:RXN-12720 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0102298 +name: selenocystathione synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine." [EC:2.5.1.-, GOC:pz] +xref: MetaCyc:RXN-12728 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102299 +name: linolenate 9R-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate." [EC:1.13.11.61, GOC:pz] +xref: EC:1.13.11.61 +xref: MetaCyc:RXN-12759 +xref: RHEA:31687 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102300 +name: linoleate 9R-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE." [GOC:pz, RHEA:31691] +xref: EC:1.13.11.61 +xref: MetaCyc:RXN-12760 +xref: RHEA:31691 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102301 +name: gamma-linolenate elongase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-12777 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102302 +name: mycinamicin VI 2''-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+." [EC:2.1.1.238, GOC:pz] +xref: EC:2.1.1.238 +xref: MetaCyc:RXN-12801 +xref: RHEA:31643 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102303 +name: resveratrol 3,5-O-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+." [EC:2.1.1.240, GOC:pz] +xref: EC:2.1.1.240 +xref: MetaCyc:RXN-12805 +xref: RHEA:32103 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102304 +name: sesquithujene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid." [EC:4.2.3.102, GOC:pz] +xref: EC:4.2.3.102 +xref: MetaCyc:RXN-12838 +xref: RHEA:31991 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102305 +name: (13E)-labda-7,13-dien-15-ol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid." [GOC:pz, RHEA:32075] +xref: EC:3.1.7.10 +xref: MetaCyc:RXN-12892 +xref: RHEA:32075 +is_a: GO:0016794 ! diphosphoric monoester hydrolase activity + +[Term] +id: GO:0102306 +name: benzil reductase [(S)-benzoin-forming] activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+." [EC:1.1.1.320, GOC:pz] +xref: EC:1.1.1.320 +xref: MetaCyc:RXN-12898 +xref: RHEA:25968 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102307 +name: erythromycin C 3''-o-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+." [EC:2.1.1.254, GOC:pz] +xref: EC:2.1.1.254 +xref: MetaCyc:RXN-12923 +xref: RHEA:32647 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102308 +name: erythromycin D 3''-o-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+." [EC:2.1.1.254, GOC:pz] +xref: EC:2.1.1.254 +xref: MetaCyc:RXN-12924 +xref: RHEA:32651 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102309 +name: dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-D-oliose + NADP <=> dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-12930 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102310 +name: dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H." [EC:1.17.1.-, GOC:pz] +xref: MetaCyc:RXN-12940 +is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor + +[Term] +id: GO:0102311 +name: 8-hydroxygeraniol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+." [EC:1.1.1.324, GOC:pz] +xref: EC:1.1.1.324 +xref: MetaCyc:RXN-12961 +xref: RHEA:32659 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102312 +name: 4-coumaroyl 2'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide." [GOC:pz, PMID:22168819, PMID:22169019] +xref: EC:1.14.11.62 +xref: MetaCyc:RXN-12963 +xref: RHEA:57868 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102313 +name: 1,8-cineole synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid." [GOC:pz, RHEA:32543] +xref: EC:4.2.3.108 +xref: MetaCyc:RXN-12980 +xref: RHEA:32543 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102317 +name: 4-methylaminobutyrate oxidase (demethylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide." [EC:1.5.3.19, GOC:pz] +xref: EC:1.5.3.19 +xref: MetaCyc:RXN-13067 +xref: RHEA:33907 +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:0102318 +name: 2-deoxystreptamine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+." [EC:2.4.1.284, GOC:pz] +xref: EC:2.4.1.284 +xref: MetaCyc:RXN-13121 +xref: RHEA:34063 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102319 +name: 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-)." [EC:2.4.1.283, GOC:pz] +xref: EC:2.4.1.283 +xref: MetaCyc:RXN-13122 +xref: RHEA:33947 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102320 +name: 1,8-cineole 2-exo-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O." [GOC:pz, RHEA:32895] +xref: EC:1.14.14.56 +xref: MetaCyc:RXN-13133 +xref: RHEA:32895 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102321 +name: 2,2'-hydroxybiphenyl monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD." [GOC:pz, RHEA:63512] +xref: EC:1.14.13.44 +xref: MetaCyc:MONOMER-17239 +xref: RHEA:63512 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102322 +name: 2-propylphenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD." [GOC:pz] +xref: MetaCyc:RXN-13151 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102323 +name: 2-isopropylphenol monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD." [GOC:pz] +xref: MetaCyc:RXN-13152 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102324 +name: 2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+." [EC:3.7.1.-, GOC:pz] +xref: MetaCyc:RXN-13157 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102325 +name: 2,2',3-trihydroxybiphenyl monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O." [GOC:pz, RHEA:63516] +xref: MetaCyc:RXN-13169 +xref: RHEA:63516 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102326 +name: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+." [EC:3.7.1.8, GOC:pz] +xref: MetaCyc:RXN-13171 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102327 +name: 3-oxoacyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid." [EC:3.1.2.-, GOC:pz] +xref: MetaCyc:RXN-13247 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102328 +name: 3-oxoacid decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone." [EC:4.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13248 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0102329 +name: hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP <=> hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13251 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102330 +name: palmitoyl-[acp] elongase/decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-13258 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102331 +name: heptadecanoyl-[acp] elongase/decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-13259 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102332 +name: fatty-acyl-[acp] elongase/decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-13260 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102333 +name: stearoyl-[acp] elongase/decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-13261 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102334 +name: N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP." [EC:2.7.8.36, GOC:pz] +xref: EC:2.7.8.36 +xref: MetaCyc:RXN-13269 +xref: RHEA:34515 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0102335 +name: N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+." [EC:2.4.1.290, GOC:pz] +xref: EC:2.4.1.290 +xref: MetaCyc:RXN-13274 +xref: RHEA:34511 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102336 +name: 3-oxo-arachidoyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A." [GOC:pz, RHEA:35319] +xref: MetaCyc:RXN-13294 +xref: RHEA:35319 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102337 +name: 3-oxo-cerotoyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A." [GOC:pz, RHEA:36515] +xref: MetaCyc:RXN-13296 +xref: RHEA:36515 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102338 +name: 3-oxo-lignoceronyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A." [GOC:pz, RHEA:36507] +xref: MetaCyc:RXN-13297 +xref: RHEA:36507 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102339 +name: 3-oxo-arachidoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) <=> 3-oxoicosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] +xref: EC:1.1.1.330 +xref: MetaCyc:RXN-13298 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102340 +name: 3-oxo-behenoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] +xref: EC:1.1.1.330 +xref: MetaCyc:RXN-13299 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102341 +name: 3-oxo-lignoceroyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP <=> 3-oxotetracosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] +xref: EC:1.1.1.330 +xref: MetaCyc:RXN-13300 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102342 +name: 3-oxo-cerotoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP <=> 3-oxohexacosanoyl-CoA + NADPH + H+." [EC:1.1.1.330, GOC:pz] +xref: EC:1.1.1.330 +xref: MetaCyc:RXN-13301 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102343 +name: 3-hydroxy-arachidoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA <=> trans-2-icosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz] +xref: EC:4.2.1.134 +xref: MetaCyc:RXN-13302 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102344 +name: 3-hydroxy-behenoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA <=> trans-2-docosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz] +xref: EC:4.2.1.134 +xref: MetaCyc:RXN-13303 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102345 +name: 3-hydroxy-lignoceroyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) <=> trans-2-tetracosenoyl-CoA + H2O." [EC:4.2.1.134, GOC:pz] +xref: EC:4.2.1.134 +xref: MetaCyc:RXN-13304 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102346 +name: 3-hydroxy-cerotoyl-CoA dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) <=> trans-2-hexacosenoyl-CoA(4-) + H2O." [EC:4.2.1.134, GOC:pz] +xref: MetaCyc:RXN-13305 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102347 +name: trans-arachidon-2-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) <=> trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+." [EC:1.3.1.93, GOC:pz] +xref: MetaCyc:RXN-13306 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102348 +name: trans-docosan-2-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: behenoyl-CoA + NADP <=> trans-2-docosenoyl-CoA + NADPH + H+." [EC:1.3.1.93, GOC:pz] +xref: MetaCyc:RXN-13307 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102349 +name: trans-lignocero-2-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetracosanoyl-CoA + NADP <=> trans-2-tetracosenoyl-CoA + NADPH + H+." [EC:1.3.1.93, GOC:pz] +xref: MetaCyc:RXN-13308 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102350 +name: trans-cerot-2-enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) <=> trans-2-hexacosenoyl-CoA + NADPH + H+." [EC:1.3.1.93, GOC:pz] +xref: MetaCyc:RXN-13309 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102351 +name: gamma-aminobutyrate transaminase (glyoxylate dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine." [EC:2.6.1.96, GOC:pz] +xref: EC:2.6.1.96 +xref: MetaCyc:RXN-13328 +xref: RHEA:32267 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0102352 +name: phosphatidate kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate." [EC:2.7.4.-, GOC:pz] +xref: MetaCyc:RXN-13336 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0102354 +name: 11-cis-retinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+." [GOC:pz, RHEA:54912] +xref: MetaCyc:RXN-13363 +xref: RHEA:54912 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102355 +name: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+." [EC:3.1.1.91, GOC:pz] +xref: EC:3.1.1.91 +xref: MetaCyc:RXN-13371 +xref: RHEA:33967 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102356 +name: isoitalicene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-13373 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102357 +name: mithramycin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: mithramycin + NADP <=> mithramycin DK + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13385 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102358 +name: daphnetin-8-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13448 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102359 +name: daphnetin 4-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+." [EC:2.4.1.126, GOC:pz] +xref: EC:2.4.1.126 +xref: MetaCyc:RXN-13450 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102360 +name: daphnetin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+." [EC:2.4.1.91, GOC:pz] +xref: EC:2.4.1.91 +xref: MetaCyc:RXN-13452 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102361 +name: esculetin 4-O-beta-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+." [EC:2.4.1.126, GOC:pz] +xref: EC:2.4.1.126 +xref: MetaCyc:RXN-13471 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102362 +name: esculetin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13472 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102363 +name: isoscopoletin-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13475 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102365 +name: taxusin 2-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O." [GOC:pz, PMID:15178487] +xref: MetaCyc:RXN-13486 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102366 +name: 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13487 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102367 +name: 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13488 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102368 +name: beta-amyrin 30-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13489 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102369 +name: 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O." [GOC:pz] +xref: MetaCyc:RXN-13491 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102370 +name: lupeol 28-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13497 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102371 +name: betulin dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-13498 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102372 +name: alpha-amyrin 28-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13500 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102373 +name: uvaol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O." [GOC:pz, PMID:22039103] +xref: EC:1.14.14.126 +xref: MetaCyc:RXN-13501 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102374 +name: ursolic aldehyde 28-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O." [GOC:pz, PMID:22039103] +xref: EC:1.14.14.126 +xref: MetaCyc:RXN-13502 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102375 +name: 11-oxo-beta-amyrin 30-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O." [GOC:pz, RHEA:35499] +xref: EC:1.14.14.115 +xref: MetaCyc:RXN-13506 +xref: RHEA:35499 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102376 +name: lupeol 28-oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13507 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102377 +name: steviol 13-O glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13511 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102378 +name: steviolmonoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13512 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102379 +name: steviolbioside glucosyltransferase activity (stevioside forming) +namespace: molecular_function +def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13514 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102380 +name: steviolbioside glucosyltransferase activity (rebaudioside B forming) +namespace: molecular_function +def: "Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13516 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102381 +name: stevioside glucosyltransferase activity (rebaudioside A forming) +namespace: molecular_function +def: "Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13517 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102382 +name: rebaudioside B glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13518 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102383 +name: steviol 19-O glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13520 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102384 +name: 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13521 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102385 +name: patchoulol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-13522 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102386 +name: phenylacetaldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13536 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102387 +name: 2-phenylethanol acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A." [EC:2.3.1.224, GOC:pz] +xref: EC:2.3.1.224 +xref: MetaCyc:RXN-13542 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102388 +name: UDP-N,N'-diacetylbacillosamine 2-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+." [EC:3.2.1.184, GOC:pz] +xref: EC:3.2.1.184 +xref: MetaCyc:RXN-13574 +xref: RHEA:34491 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102389 +name: polyprenol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol." [EC:1.3.1.94, GOC:pz] +xref: EC:1.3.1.94 +xref: MetaCyc:RXN-13604 +xref: RHEA:34279 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102390 +name: mycophenolic acid acyl-glucuronide esterase activity +namespace: molecular_function +def: "Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate." [EC:3.1.1.93, GOC:pz] +xref: EC:3.1.1.93 +xref: MetaCyc:RXN-13605 +xref: RHEA:34179 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102391 +name: decanoate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA." [GOC:pz, RHEA:33627] +xref: MetaCyc:RXN-13614 +xref: RHEA:33627 +is_a: GO:0031956 ! medium-chain fatty acid-CoA ligase activity + +[Term] +id: GO:0102392 +name: decanoate-[HmqF protein] ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN-13623 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0102393 +name: decanoyl-[acp] 2-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein <=> FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF." [EC:1.3.8.-, GOC:pz] +xref: MetaCyc:RXN-13624 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102394 +name: 4-hydroxy-L-isoleucine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD <=> (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13637 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102395 +name: 9-cis-beta-carotene 9',10'-cleavage oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone." [EC:1.13.11.68, GOC:pz] +xref: EC:1.13.11.68 +xref: MetaCyc:RXN-13642 +xref: RHEA:34399 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102396 +name: 9-cis-10'-apo-beta-carotenal cleavage oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal." [EC:1.13.11.69, GOC:pz] +xref: EC:1.13.11.69 +xref: MetaCyc:RXN-13643 +xref: RHEA:34403 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102398 +name: dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13657 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102399 +name: dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13658 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102400 +name: dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13667 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102402 +name: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose." [EC:3.2.1.149, GOC:pz] +xref: EC:3.2.1.149 +xref: MetaCyc:RXN-13694 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102404 +name: linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity +namespace: molecular_function +def: "Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool." [EC:3.2.1.149, GOC:pz] +xref: EC:3.2.1.149 +xref: MetaCyc:RXN-13701 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102405 +name: (+)-taxifolin 5'-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O." [GOC:pz] +xref: MetaCyc:RXN-13718 +xref: RHEA:61116 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102406 +name: omega-hydroxypalmitate O-sinapoyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate." [EC:2.3.1.188, GOC:pz] +xref: EC:2.3.1.188 +xref: MetaCyc:RXN-13728 +xref: RHEA:26470 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102407 +name: sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate <=> coenzyme A + 2-C22:0-DCA-LPA." [EC:2.3.1.198, GOC:pz] +xref: MetaCyc:RXN-13734 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102408 +name: sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA." [EC:2.3.1.198, GOC:pz] +xref: MetaCyc:RXN-13735 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102409 +name: sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) <=> coenzyme A + 2-docosanoyl-glycerol 3-phosphate." [EC:2.3.1.198, GOC:pz] +xref: MetaCyc:RXN-13736 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102410 +name: quercetin-4',3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13765 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102411 +name: quercetin-3,4'-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-)." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13766 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102412 +name: valerena-4,7(11)-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid." [EC:4.2.3.139, GOC:pz] +xref: EC:4.2.3.139 +xref: MetaCyc:RXN-13769 +xref: RHEA:34467 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102413 +name: 6-O-methyl-deacetylisoipecoside beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-13791 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102414 +name: quercetin-3-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13797 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102415 +name: quercetin gentiobioside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13798 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102416 +name: quercetin gentiotrioside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13799 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102417 +name: apigenin-7-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13800 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102418 +name: luteolin-7-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13801 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102419 +name: sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA." [EC:2.3.1.198, GOC:pz] +xref: EC:2.3.1.198 +xref: MetaCyc:RXN-13803 +xref: RHEA:33559 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102420 +name: sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate." [EC:2.3.1.15, GOC:pz] +xref: EC:2.3.1.15 +xref: MetaCyc:RXN-13805 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102421 +name: curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13813 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102422 +name: curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13814 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102423 +name: (+)-sesaminol 2-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:18248594, PMID:19561332] +xref: MetaCyc:RXN-13818 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102424 +name: sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13821 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102425 +name: myricetin 3-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP." [EC:2.4.1.91, GOC:pz] +xref: EC:2.4.1.91 +xref: MetaCyc:RXN-13822 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102426 +name: myricetin-3-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13823 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102427 +name: allocryptopine 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-13828 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102428 +name: kaempferol-3-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13830 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102429 +name: genistein-3-O-glucoside 1,6-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-13831 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102430 +name: alpha-linolenate delta5 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-13857 +xref: RHEA:38039 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102431 +name: acyl-lipid omega-(9-4) desaturase +namespace: molecular_function +def: "Catalysis of the reaction: linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H(+) <=> pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O." [GOC:pz, RHEA:46236] +synonym: "linoleate delta5 desaturase activity" RELATED [] +xref: EC:1.14.19.12 +xref: MetaCyc:RXN-13858 +xref: RHEA:46236 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102432 +name: quercetin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13906 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102433 +name: phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine." [EC:1.14.16.1, GOC:pz] +xref: MetaCyc:RXN-13907 +is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102434 +name: pterin-4alpha-carbinolamine dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate." [GOC:pz, PMID:18245455, PMID:20959559] +xref: MetaCyc:RXN-13908 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102435 +name: myricetin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13910 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102436 +name: 7-methylmyricetin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13911 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102438 +name: laricitrin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13914 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102439 +name: 3',4',5'-trimethylmyricetin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13916 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102440 +name: 3',4',5'-trimethylmyricetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13918 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102441 +name: syringetin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13919 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102442 +name: syringetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13920 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102443 +name: L-2-hydroxycarboxylate dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate." [EC:1.1.1.337, GOC:pz] +xref: EC:1.1.1.337 +xref: MetaCyc:RXN-13927 +xref: RHEA:34555 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102444 +name: isorhamnetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13929 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102445 +name: 3-methylquercetin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13930 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102446 +name: rhamnetin 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13932 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102447 +name: rhamnetin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13933 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102448 +name: rhamnetin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13934 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102449 +name: kaempferol 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13935 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102450 +name: kaempferide 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13936 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102451 +name: kaempferide 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-13937 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102452 +name: bisdemethoxycurcumin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide." [EC:2.3.1.211, GOC:pz] +xref: EC:2.3.1.211 +xref: MetaCyc:RXN-13958 +xref: RHEA:34803 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102453 +name: anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]." [GOC:pz, RHEA:35411] +xref: EC:2.3.1.215 +xref: MetaCyc:RXN-13959 +xref: RHEA:35411 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102454 +name: cyanidin 3-O-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP." [GOC:pz, RHEA:35631] +xref: EC:2.4.1.294 +xref: MetaCyc:RXN-13960 +xref: RHEA:35631 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102455 +name: anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside." [GOC:pz, RHEA:35419] +xref: EC:2.4.1.297 +xref: MetaCyc:RXN-13965 +xref: RHEA:35419 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102456 +name: cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+." [EC:2.4.1.299, GOC:pz] +xref: MetaCyc:RXN-13967 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102457 +name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate." [EC:2.4.1.300, GOC:pz] +xref: EC:2.4.1.300 +xref: MetaCyc:RXN-13969 +xref: RHEA:35431 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102458 +name: cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+." [EC:2.4.1.299, GOC:pz] +xref: EC:2.4.1.299 +xref: MetaCyc:RXN-13970 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102459 +name: 8-oxo-deoxyadenine diphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+." [EC:3.6.1.-, GOC:pz] +xref: MetaCyc:RXN-14005 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102460 +name: kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14008 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102461 +name: kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14009 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102462 +name: quercetin 3-sophoroside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14011 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102463 +name: quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14012 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102464 +name: zeaxanthin 2-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD." [GOC:pz, PMID:22509387] +xref: MetaCyc:RXN-14016 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102465 +name: zeaxanthin 2,2'-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O." [GOC:pz] +xref: MetaCyc:RXN-14018 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102466 +name: beta-carotene 2,2'-beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14019 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102467 +name: scutellarein 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+." [EC:2.4.1.253, GOC:pz] +xref: EC:2.4.1.253 +xref: MetaCyc:RXN-14058 +xref: RHEA:28318 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102468 +name: wogonin 7-O-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+." [EC:2.4.1.253, GOC:pz] +xref: EC:2.4.1.253 +xref: MetaCyc:RXN-14060 +xref: RHEA:28322 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102469 +name: naringenin 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14069 +xref: RHEA:57588 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102470 +name: 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14075 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102471 +name: 2-hydroxynaringenin-6C-glucoside dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O." [EC:4.2.1.-, GOC:pz] +xref: MetaCyc:RXN-14076 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102472 +name: eriodictyol 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14077 +xref: RHEA:57596 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102473 +name: eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14079 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102474 +name: eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14080 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102475 +name: 2-hydroxyeriodictyol 6C-glucoside dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O." [EC:4.2.1.-, GOC:pz] +xref: MetaCyc:RXN-14081 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102476 +name: pinocembrin 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14083 +xref: RHEA:57592 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102477 +name: 2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O." [EC:4.2.1.-, GOC:pz] +xref: MetaCyc:RXN-14088 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102478 +name: beta-L-arabinofuranosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose." [GOC:pz, RHEA:36051] +xref: EC:3.2.1.185 +xref: MetaCyc:RXN-14089 +xref: RHEA:36051 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102479 +name: quercetin 3-O-beta:-D-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+." [EC:2.4.1.234, GOC:pz] +xref: EC:2.4.1.234 +xref: MetaCyc:RXN-14109 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102480 +name: 5-fluorocytosine deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium." [EC:3.5.4.1, GOC:pz] +xref: EC:3.5.4.1 +xref: MetaCyc:RXN-14129 +is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines + +[Term] +id: GO:0102481 +name: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+." [EC:3.7.1.22, GOC:pz] +xref: EC:3.7.1.22 +xref: MetaCyc:RXN-14149 +xref: RHEA:25836 +is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances + +[Term] +id: GO:0102482 +name: 5-deoxy-D-glucuronate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate." [GOC:pz, RHEA:25840] +xref: EC:5.3.1.30 +xref: MetaCyc:RXN-14150 +xref: RHEA:25840 +is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses + +[Term] +id: GO:0102483 +name: scopolin beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin." [EC:3.2.1.21, GOC:pz] +xref: EC:3.2.1.21 +xref: MetaCyc:RXN-14179 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102484 +name: esculetin glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14182 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102485 +name: dATP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14195 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102486 +name: dCTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14198 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102487 +name: dUTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14199 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102488 +name: dTTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14200 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102489 +name: GTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14201 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102490 +name: 8-oxo-dGTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14205 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102491 +name: dGTP phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+." [EC:3.6.1.5, GOC:pz] +xref: EC:3.6.1.5 +xref: MetaCyc:RXN-14208 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0102493 +name: wogonin 7-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+." [GOC:pz, PMID:10872235] +xref: MetaCyc:RXN-14239 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102494 +name: GA20 2,3-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-14317 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102495 +name: GA5 3beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-14318 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102496 +name: GA5 2,3 epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-14327 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102497 +name: scyllo-inositol dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+." [EC:1.1.1.371, GOC:pz] +xref: EC:1.1.1.371 +xref: MetaCyc:RXN-14347 +xref: RHEA:39063 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102498 +name: maltose glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + maltose = 2 glucose." [GOC:pz, PMID:16343940] +xref: MetaCyc:RXN-15910 +is_a: GO:0090599 ! alpha-glucosidase activity + +[Term] +id: GO:0102499 +name: SHG alpha-glucan phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan." [GOC:pz, RHEA:41732] +xref: EC:2.4.1.1 +xref: MetaCyc:RXN-14353 +xref: RHEA:41732 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102500 +name: beta-maltose 4-alpha-glucanotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose." [EC:2.4.1.25, GOC:pz] +xref: EC:2.4.1.25 +xref: MetaCyc:RXN-14354 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102501 +name: D-fructuronate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate." [GOC:pz, PMID:22925190] +xref: MetaCyc:RXN-14368 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102502 +name: ADP-glucose-starch glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose." [EC:2.4.1.242, GOC:pz] +xref: EC:2.4.1.242 +xref: MetaCyc:RXN-14378 +is_a: GO:0033840 ! NDP-glucose-starch glucosyltransferase activity + +[Term] +id: GO:0102504 +name: luteolinidin 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14424 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102505 +name: apigeninidin 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-14427 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102506 +name: cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+." [EC:2.4.1.299, GOC:pz] +xref: EC:2.4.1.299 +xref: MetaCyc:RXN-14432 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102507 +name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+." [EC:2.4.1.300, GOC:pz] +xref: EC:2.4.1.300 +xref: MetaCyc:RXN-14434 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102508 +name: cyanidin 3,7-diglucoside glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-14435 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102509 +name: cyanidin 3,5-diglucoside glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-14436 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102510 +name: pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+." [EC:2.4.1.299, GOC:pz] +xref: EC:2.4.1.299 +xref: MetaCyc:RXN-14439 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102511 +name: pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+." [EC:2.4.1.300, GOC:pz] +xref: EC:2.4.1.300 +xref: MetaCyc:RXN-14440 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102512 +name: delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+." [EC:2.4.1.299, GOC:pz] +xref: EC:2.4.1.299 +xref: MetaCyc:RXN-14441 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102513 +name: delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+." [EC:2.4.1.300, GOC:pz] +xref: MetaCyc:RXN-14442 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102514 +name: cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+." [EC:2.4.1.300, GOC:pz] +xref: EC:2.4.1.300 +xref: MetaCyc:RXN-14446 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102515 +name: pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+." [EC:2.4.1.300, GOC:pz] +xref: MetaCyc:RXN-14447 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102516 +name: delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+." [EC:2.4.1.300, GOC:pz] +xref: MetaCyc:RXN-14448 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102517 +name: oleate 12-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14487 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102518 +name: (11Z)-eicosenoate 14-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O." [EC:1.14.18.4, GOC:pz, PMID:8784737, PMID:9680976] +xref: EC:1.14.18.4 +xref: MetaCyc:RXN-14488 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102520 +name: L-threonine O-3-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN-14505 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0102521 +name: tRNA-4-demethylwyosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe." [GOC:pz, PMID:34184886, RHEA:36347] +xref: EC:4.1.3.44 +xref: MetaCyc:RXN-14516 +xref: RHEA:36347 +is_a: GO:0016833 ! oxo-acid-lyase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0102522 +name: tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe." [EC:2.5.1.114, GOC:pz] +xref: EC:2.5.1.114 +xref: MetaCyc:RXN-14518 +xref: RHEA:36355 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0102523 +name: 2-chloroacrylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+." [EC:1.3.1.103, GOC:pz] +xref: EC:1.3.1.103 +xref: MetaCyc:RXN-14536 +xref: RHEA:36591 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102524 +name: tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe." [GOC:pz, RHEA:37899] +xref: EC:1.14.11.42 +xref: MetaCyc:RXN-14538 +xref: RHEA:37899 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0102525 +name: 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide." [GOC:pz, RHEA:36607] +xref: EC:1.14.11.41 +xref: MetaCyc:RXN-14542 +xref: RHEA:36607 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102526 +name: 8-demethylnovobiocic acid C8-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+." [EC:2.1.1.284, GOC:pz] +xref: EC:2.1.1.284 +xref: MetaCyc:RXN-14543 +xref: RHEA:36651 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102527 +name: 8-demethylnovobiocate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid." [EC:6.3.1.15, GOC:pz] +xref: EC:6.3.1.15 +xref: MetaCyc:RXN-14547 +xref: RHEA:36699 +is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity + +[Term] +id: GO:0102528 +name: 7,8,4'-trihydroxyflavone methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-14658 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102529 +name: apigenin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-14661 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102530 +name: aclacinomycin T methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+." [EC:3.1.1.95, GOC:pz] +xref: EC:3.1.1.95 +xref: MetaCyc:RXN-14703 +xref: RHEA:37891 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102531 +name: ecdysteroid-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid." [GOC:pz, PMID:12721294] +xref: MetaCyc:RXN-14734 +xref: RHEA:63576 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0102532 +name: genkwanin 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14748 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102533 +name: genkwanin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-14750 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102534 +name: apigenin-7,4'-dimethyl ether 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-14751 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102535 +name: ladanein 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-14752 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102536 +name: sakuranetin 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP." [GOC:pz, PMID:23184958] +xref: MetaCyc:RXN-14754 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102537 +name: ecdysone-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN-14766 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0102538 +name: UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H." [GOC:pz, PMID:10627048, PMID:24817117] +xref: MetaCyc:RXN-14767 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102539 +name: UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H." [GOC:pz, PMID:10627048] +xref: MetaCyc:RXN-14769 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102540 +name: D-mannose 6-phosphate 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate." [EC:5.1.3.-, GOC:pz] +xref: MetaCyc:RXN-14815 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0102541 +name: D-galactose 6-phosphate 1-epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate." [EC:5.1.3.-, GOC:pz] +xref: MetaCyc:RXN-14816 +is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives + +[Term] +id: GO:0102542 +name: aclacinomycin A methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+." [EC:3.1.1.95, GOC:pz] +xref: EC:3.1.1.95 +xref: MetaCyc:RXN-14863 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102543 +name: epsilon-rhodomycinone methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+." [EC:3.1.1.95, GOC:pz] +xref: EC:3.1.1.95 +xref: MetaCyc:RXN-14865 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102544 +name: ornaline synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O." [EC:1.5.1.-, GOC:pz] +xref: MetaCyc:RXN-14880 +is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102545 +name: phosphatidyl phospholipase B activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate." [EC:3.1.1.5, GOC:pz] +xref: EC:3.1.1.5 +xref: MetaCyc:RXN-14899 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102546 +name: mannosylglycerate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate." [EC:3.3.2.-, GOC:pz] +xref: MetaCyc:RXN-14900 +xref: RHEA:58456 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0102547 +name: glucosylglycerate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate." [EC:3.3.2.-, GOC:pz] +xref: MetaCyc:RXN-14901 +xref: RHEA:32059 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0102549 +name: 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+." [EC:3.1.1.26, GOC:pz] +xref: EC:3.1.1.26 +xref: MetaCyc:RXN-14912 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102550 +name: 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+." [EC:2.1.1.295, GOC:pz] +xref: EC:2.1.1.295 +xref: MetaCyc:RXN-14917 +xref: RHEA:38007 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102551 +name: homogentisate geranylgeranyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide." [EC:2.5.1.116, GOC:pz] +xref: EC:2.5.1.116 +xref: MetaCyc:RXN-14929 +xref: RHEA:38003 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102552 +name: lipoyl synthase activity (acting on glycine-cleavage complex H protein +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [EC:2.8.1.8, GOC:pz] +xref: EC:2.8.1.8 +xref: MetaCyc:RXN-14950 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0102553 +name: lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [EC:2.8.1.8, GOC:pz] +xref: EC:2.8.1.8 +xref: MetaCyc:RXN-14957 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0102554 +name: lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]." [EC:2.8.1.8, GOC:pz] +xref: MetaCyc:RXN-14959 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0102555 +name: octanoyl transferase activity (acting on glycine-cleavage complex H protein) +namespace: molecular_function +def: "Catalysis of the reaction: [glycine cleavage system lipoyl-carrier protein]-L-lysine + octanoyl-ACP = H+ + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein]." [GOC:pz, RHEA:17665] +xref: EC:2.3.1.181 +xref: MetaCyc:RXN-14966 +xref: RHEA:17665 +is_a: GO:0016415 ! octanoyltransferase activity + +[Term] +id: GO:0102556 +name: dammarenediol 12-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O." [EC:1.14.14.120, GOC:pz] +xref: EC:1.14.14.120 +xref: MetaCyc:RXN-14975 +xref: RHEA:38579 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102557 +name: protopanaxadiol 6-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O." [EC:1.14.14.121, GOC:pz] +xref: EC:1.14.14.121 +xref: MetaCyc:RXN-14978 +xref: RHEA:22272 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102559 +name: protein-(glutamine-N5) methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine." [GOC:pz, RHEA:42896] +xref: EC:2.1.1.297 +xref: MetaCyc:RXN-14992 +xref: RHEA:42896 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102560 +name: 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+." [EC:3.1.4.57, GOC:pz] +synonym: "phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase" EXACT [] +xref: EC:3.1.4.57 +xref: MetaCyc:RXN-14995 +xref: RHEA:41612 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0102561 +name: D-ribose 2,5-bisphosphate 2-phosphohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate." [GOC:pz, RHEA:41616] +xref: EC:3.1.4.57 +xref: MetaCyc:RXN-14996 +xref: RHEA:41616 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0102562 +name: hydroxyproline O-arbinofuranose transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline." [EC:2.4.2.-, GOC:pz] +xref: MetaCyc:RXN-15011 +xref: RHEA:49472 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0102563 +name: aurachin C monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15029 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102564 +name: aurachin C epoxide hydrolase/isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)." [EC:3.3.2.-, GOC:pz] +xref: MetaCyc:RXN-15030 +xref: RHEA:48728 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0102566 +name: 1-acyl dihydroxyacetone phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP." [EC:1.1.1.101, GOC:pz] +xref: EC:1.1.1.101 +xref: MetaCyc:RXN-15046 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102569 +name: FR-33289 synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-15082 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102570 +name: tyrosine:phenylpyruvate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate." [EC:2.6.1.-, GOC:pz] +xref: MetaCyc:RXN-15200 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0102571 +name: [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)." [EC:3.2.1.169, GOC:pz] +xref: EC:3.2.1.169 +xref: MetaCyc:RXN-15215 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102572 +name: N-glutamylanilide hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+." [EC:3.5.1.-, GOC:pz] +xref: MetaCyc:RXN-15251 +xref: RHEA:50684 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0102573 +name: aminodeoxyfutalosine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+." [EC:2.5.1.120, GOC:pz] +xref: EC:2.5.1.120 +xref: MetaCyc:RXN-15264 +xref: RHEA:33075 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102574 +name: 3-oxo-myristoyl-ACP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]." [EC:3.1.2.-, GOC:pz] +xref: MetaCyc:RXN-15280 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102575 +name: 3-oxo-dodecanoyl-ACP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]." [EC:3.1.2.-, GOC:pz] +xref: MetaCyc:RXN-15281 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102576 +name: 3-oxo-palmitoyl-ACP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]." [EC:3.1.2.-, GOC:pz] +xref: MetaCyc:RXN-15282 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102577 +name: 3-oxo-palmitate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide." [EC:4.1.1.56, GOC:pz] +xref: EC:4.1.1.56 +xref: MetaCyc:RXN-15283 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0102580 +name: cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP." [EC:2.4.2.51, GOC:pz] +xref: EC:2.4.2.51 +xref: MetaCyc:RXN-15326 +xref: RHEA:35443 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0102581 +name: cyanidin 3-O-glucoside-p-coumaroyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15327 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102582 +name: cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+." [EC:2.4.2.-, GOC:pz] +xref: MetaCyc:RXN-15328 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0102583 +name: cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15329 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102584 +name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+." [GOC:pz, PMID:15807784] +xref: MetaCyc:RXN-15330 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102585 +name: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A." [GOC:pz, PMID:17292360] +xref: MetaCyc:RXN-15331 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102586 +name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15332 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102587 +name: cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-15333 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102588 +name: cyanidin 3-O-glucoside 6''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A." [EC:2.3.1.171, GOC:pz] +xref: EC:2.3.1.171 +xref: MetaCyc:RXN-15335 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102589 +name: cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15336 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102590 +name: delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-15351 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102591 +name: delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15352 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102592 +name: delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15354 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102593 +name: UDP-glucose: N-methylanthranilate glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-15371 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102594 +name: cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15372 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102595 +name: cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15374 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102596 +name: cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O." [EC:1.14.14.70, GOC:pz] +xref: EC:1.14.14.70 +xref: MetaCyc:RXN-15379 +xref: RHEA:41464 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102597 +name: 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O." [EC:1.14.14.122, GOC:pz] +xref: EC:1.14.14.122 +xref: MetaCyc:RXN-15381 +xref: RHEA:41468 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102598 +name: 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O." [EC:1.14.14.123, GOC:pz] +xref: EC:1.14.14.123 +xref: MetaCyc:RXN-15382 +xref: RHEA:41472 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102599 +name: cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15383 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102600 +name: cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15384 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102601 +name: cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP." [GOC:pz, RHEA:55440] +xref: EC:1.14.14.63 +xref: MetaCyc:RXN-15385 +xref: RHEA:55440 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102602 +name: cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P)." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15386 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102603 +name: 12-demethyl-elloramycin C12a O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15402 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102604 +name: naringenin,NADPH:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-naringenin(1-) + O2 + NADPH + H+ <=> 2-hydroxy-2,3-dihydrogenistein-7-olate + NADP + H2O." [EC:1.14.14.87, GOC:pz] +xref: EC:1.14.14.87 +xref: MetaCyc:RXN-1541 +xref: RHEA:35487 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102605 +name: cyclooctat-9-en-5,7-diol C18-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15430 +xref: RHEA:56824 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102606 +name: octat-9-en-7-ol 5-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15431 +xref: RHEA:56820 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102607 +name: 3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15433 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102608 +name: tetracenomycin B3 8-O-methyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15435 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102610 +name: (+)-secoisolariciresinol glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+." [GOC:pz, PMID:24678929] +xref: MetaCyc:RXN-15442 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102611 +name: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+." [GOC:pz, PMID:24678929] +xref: MetaCyc:RXN-15443 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102612 +name: syn-pimaradiene 6beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O." [GOC:pz, PMID:22215681] +xref: MetaCyc:RXN-15452 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102613 +name: trimethyluric acid monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O." [GOC:pz, RHEA:48992] +xref: MetaCyc:RXN-15454 +xref: RHEA:48992 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102614 +name: germacrene A acid 8beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15460 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102615 +name: ent-cassadiene-C2-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15462 +xref: RHEA:55484 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102616 +name: oryzalexin A synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin A + H+ + NAD(P)H." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15464 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102617 +name: oryzalexin C synthase (oryzalexin B dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: oryzalexin B + NAD(P) <=> oryzalexin C + H+ + NAD(P)H." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15465 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102618 +name: oryzalexin B synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin B + H+ + NAD(P)H." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15466 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102619 +name: oryzalexin C synthase (oryzalexin A dependent) activity +namespace: molecular_function +def: "Catalysis of the reaction: oryzalexin A + NAD(P) <=> oryzalexin C + H+ + NAD(P)H." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15467 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102620 +name: 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15495 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102621 +name: emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity +namespace: molecular_function +def: "Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15496 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102622 +name: linuron hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline." [EC:3.5.1.-, GOC:pz] +xref: MetaCyc:RXN-15526 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0102623 +name: scutellarein 7-methyl ether 6-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15528 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102624 +name: scutellarein 7-methyl ether 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15529 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102625 +name: cirsimaritin 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15530 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102626 +name: parthenolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15531 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102627 +name: parthenolide 3beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15532 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102628 +name: costunolide 3beta-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15533 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102629 +name: patuletin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15534 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102630 +name: gossypetin 8-methyl ester 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15536 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102631 +name: caffeoylglucose 3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-15537 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102632 +name: (S)-nandinine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O." [GOC:pz, PMID:17250743, PMID:21094631, RHEA:50364] +xref: EC:1.14.19.73 +xref: MetaCyc:RXN-15538 +xref: RHEA:50364 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102633 +name: flaviolin monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15585 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102634 +name: 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+." [GOC:pz, PMID:15701630] +xref: MetaCyc:RXN-15586 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0102635 +name: 11-deoxycorticosterone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD." [GOC:pz, HEA:47716] +xref: MetaCyc:RXN-15607 +xref: RHEA:47716 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102636 +name: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine <=> 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate." [EC:2.3.2.-, GOC:pz] +xref: MetaCyc:RXN-15681 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0102637 +name: 5-aminolevulinate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN-15714 +is_a: GO:0016405 ! CoA-ligase activity +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0102638 +name: [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid." [EC:2.5.1.105, GOC:pz] +xref: EC:2.5.1.105 +xref: MetaCyc:RXN-15734 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102639 +name: paspalicine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15737 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102640 +name: paspalinine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-15738 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102641 +name: (R)-lactaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+." [GOC:pz] +xref: MetaCyc:RXN-15743 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102643 +name: scalarane-17alpha-19-diol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O." [EC:4.2.1.-, GOC:pz] +xref: MetaCyc:RXN-15755 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102644 +name: monocyclic sesterterpenediol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O." [EC:4.2.1.-, GOC:pz] +xref: MetaCyc:RXN-15756 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102645 +name: 17(E)-cheilanthenediol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O." [GOC:pz, PMID:24200803] +xref: MetaCyc:RXN-15758 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102646 +name: 14betaH-scalarane-17alpha-19-diol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O." [GOC:pz, PMID:24200803] +xref: MetaCyc:RXN-15759 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102647 +name: D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate." [EC:2.2.1.-, GOC:pz] +xref: MetaCyc:RXN-15789 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0102648 +name: D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate." [EC:2.2.1.-, GOC:pz] +xref: MetaCyc:RXN-15790 +is_a: GO:0016744 ! transketolase or transaldolase activity + +[Term] +id: GO:0102649 +name: acetoacetyl-ACP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-15810 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102650 +name: cyclo-acetoacetyl-L-tryptophan synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]." [EC:6.3.2.-, GOC:pz] +xref: MetaCyc:RXN-15811 +is_a: GO:0016881 ! acid-amino acid ligase activity + +[Term] +id: GO:0102652 +name: gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-171 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102653 +name: gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-172 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102654 +name: 1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46764] +xref: EC:1.14.19.43 +xref: MetaCyc:RXN-1725 +xref: RHEA:46764 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102655 +name: 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-1726 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102656 +name: 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-1727 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102657 +name: 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15579662] +xref: EC:1.14.19.42 +xref: MetaCyc:RXN-1728 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102658 +name: 2-oxo-5-methylthiopentanoate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate." [EC:2.6.1.-, GOC:pz] +xref: MetaCyc:RXN-2205 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0102659 +name: UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXN-2208 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102660 +name: caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-2621 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102661 +name: homogentisate solanyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid." [EC:2.5.1.117, GOC:pz] +xref: EC:2.5.1.117 +xref: MetaCyc:RXN-2761 +xref: RHEA:37995 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102662 +name: malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-)." [EC:1.2.1.-, GOC:pz] +xref: MetaCyc:RXN-2902 +xref: RHEA:22992 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102663 +name: gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-292 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102664 +name: indole-3-acetyl-leucine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-2945 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102665 +name: indole-3-acetyl-glutamate synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-2947 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102666 +name: indole-3-acetyl-beta-4-D-glucose hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose." [EC:3.1.-.-, GOC:pz] +xref: MetaCyc:RXN-3164 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0102667 +name: indole-3-acetyl-beta-1-D-glucose hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose." [EC:3.1.-.-, GOC:pz] +xref: MetaCyc:RXN-3165 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0102668 +name: liquiritigenin,NADPH:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: liquiritigenin + NADPH + O2 + H+ <=> 2,4',7-trihydroxyisoflavanone + NADP(3-) + H2O." [EC:1.14.14.87, GOC:pz] +xref: EC:1.14.14.87 +xref: MetaCyc:RXN-3283 +xref: RHEA:31723 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102669 +name: isoflavone-7-O-glucoside beta-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose." [EC:3.2.1.-, GOC:pz] +xref: MetaCyc:RXN-3591 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102670 +name: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine." [EC:2.1.1.212, GOC:pz] +xref: EC:2.1.1.212 +xref: MetaCyc:RXN-3624 +xref: RHEA:31371 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102671 +name: 6a-hydroxymaackiain-3-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine." [EC:2.1.1.270, GOC:pz] +xref: EC:2.1.1.270 +xref: MetaCyc:RXN-4002 +xref: RHEA:35471 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102672 +name: fatty acid alpha-oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid." [EC:1.13.11.-, GOC:pz] +xref: MetaCyc:RXN-4121 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102673 +name: fatty aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid." [EC:1.2.1.3, GOC:pz] +xref: MetaCyc:RXN-4142 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102674 +name: obsolete C4-demethylase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 24-methylenelophenol + a demethylated methyl acceptor <=> 9xi-episterol + a methylated methyl acceptor." [EC:2.1.1.-, GOC:pz] +comment: This term was obsoleted because there is no evidence that this actvity exists. +xref: MetaCyc:RXN-4181 +is_obsolete: true + +[Term] +id: GO:0102675 +name: obsolete C4-methyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: 24-ethylidenelophenol + a demethylated methyl acceptor <=> avenasterol + a methylated methyl acceptor." [EC:2.1.1.-, GOC:pz] +comment: This term was obsoleted because there is no evidence that this actvity exists. +xref: MetaCyc:RXN-4208 +is_obsolete: true + +[Term] +id: GO:0102676 +name: avenasterol-desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-4209 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102677 +name: campesterol,NADPH:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-4225 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102678 +name: 22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-4229 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102679 +name: (5alpha)-campestan-3-one hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP." [GOC:pz, PMID:10377996] +xref: MetaCyc:RXN-4230 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102680 +name: campest-4-en-3-one hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-4231 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102681 +name: isoamylase (maltodextrin-releasing) activity +namespace: molecular_function +def: "Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin." [EC:3.2.1.68, GOC:pz] +xref: MetaCyc:RXN-4301 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102682 +name: N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate." [EC:3.2.2.-, GOC:pz] +xref: MetaCyc:RXN-4313 +xref: RHEA:48560 +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0102684 +name: L-phenylalanine N-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide." [EC:1.14.14.40, GOC:pz] +xref: EC:1.14.14.40 +xref: MetaCyc:RXN-4602 +xref: RHEA:33263 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102685 +name: UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4721 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102686 +name: UDP-glucose:trans-zeatin 9-N-glucosyltransferase +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-)." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4722 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102687 +name: UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4724 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102688 +name: dihydrozeatin UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4725 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102689 +name: UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4727 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102690 +name: isopentenyladenine UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4728 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102691 +name: UDP-glucose:benzyladenine 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4729 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102692 +name: benzyladenine UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4730 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102693 +name: UDP-glucose:kinetin 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4731 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102694 +name: kinetin UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4732 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102695 +name: UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4733 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102696 +name: cis-zeatin UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4734 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102697 +name: trans-zeatin-O-glucoside UDP glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-4736 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102698 +name: 5-epi-aristolochene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid." [EC:4.2.3.61, GOC:pz] +xref: EC:4.2.3.61 +xref: MetaCyc:RXN-4781 +xref: RHEA:28635 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102699 +name: 2-methylpropionitrile hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-5082 +xref: RHEA:51964 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102700 +name: alpha-thujene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-5105 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102701 +name: tricyclene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid." [EC:4.2.3.105, GOC:pz] +xref: EC:4.2.3.105 +xref: MetaCyc:RXN-5121 +xref: RHEA:32687 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102702 +name: 2-carene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid." [GOC:pz, PMID:10700382] +xref: MetaCyc:RXN-5122 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102703 +name: camphene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid." [EC:4.2.3.117, GOC:pz] +xref: EC:4.2.3.117 +xref: MetaCyc:RXN-5142 +xref: RHEA:25484 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102704 +name: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol." [EC:2.4.1.257, GOC:pz] +xref: EC:2.4.1.257 +xref: MetaCyc:RXN-5463 +xref: RHEA:29519 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102705 +name: serine decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide." [GOC:pz, PMID:11461929, RHEA:45824] +xref: MetaCyc:RXN-5641 +xref: RHEA:45824 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0102706 +name: butein:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+." [GOC:pz, RHEA:34203] +xref: EC:1.21.3.6 +xref: MetaCyc:RXN-6242 +xref: RHEA:34203 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0102707 +name: S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine." [EC:2.1.1.49, GOC:pz] +xref: EC:2.1.1.49 +xref: MetaCyc:RXN-6461 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0102708 +name: S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-6462 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0102709 +name: S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-6464 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0102710 +name: D-inositol-3-phosphate glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+." [GOC:pz, RHEA:26188] +xref: EC:2.4.1.250 +xref: MetaCyc:RXN-6501 +xref: RHEA:26188 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102711 +name: gibberellin A25,oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6541 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102712 +name: gibberellin A13,oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6542 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102713 +name: gibberellin A25 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6543 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102714 +name: gibberellin A12,oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6544 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102715 +name: gibberellin A17,oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6546 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102716 +name: gibberellin A28,oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-6547 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102717 +name: DIBOA-glucoside oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide." [EC:1.14.11.59, GOC:pz] +xref: EC:1.14.11.59 +xref: MetaCyc:RXN-6685 +xref: RHEA:32115 +is_a: GO:0050498 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated + +[Term] +id: GO:0102718 +name: TRIBOA-glucoside methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.241, GOC:pz] +xref: EC:2.1.1.241 +xref: MetaCyc:RXN-6687 +xref: RHEA:32099 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102719 +name: S-adenosyl-L-methionine:eugenol-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine." [EC:2.1.1.146, GOC:pz] +xref: EC:2.1.1.146 +xref: MetaCyc:RXN-6741 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102720 +name: acetyl-coenzyme A:acetyl alcohol acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A." [EC:2.3.1.224, GOC:pz] +xref: EC:2.3.1.224 +xref: MetaCyc:RXN-6762 +xref: RHEA:36147 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102721 +name: ubiquinol:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone." [GOC:pz, RHEA:30255] +xref: EC:1.10.3.11 +xref: MetaCyc:RXN-6883 +xref: RHEA:30255 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0102722 +name: gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-6903 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102723 +name: UDP-glucose:curcumin glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-7062 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102724 +name: UDP-glucose:curcumin monoglucoside glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-7063 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102725 +name: 24-methyldesmosterol reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP." [EC:1.3.-.-, GOC:pz] +xref: MetaCyc:RXN-708 +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0102726 +name: DIMBOA glucoside beta-D-glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose." [EC:3.2.1.182, GOC:pz] +xref: EC:3.2.1.182 +xref: MetaCyc:RXN-7082 +xref: RHEA:33975 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102727 +name: 3beta-hydroxysteroid dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-710 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102728 +name: campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-711 +xref: RHEA:54416 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102729 +name: 6-oxocampestanol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-715 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102730 +name: cathasterone hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-716 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102731 +name: D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP." [EC:2.7.1.-, GOC:pz] +xref: MetaCyc:RXN-7185 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0102732 +name: myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP." [EC:2.7.1.140, GOC:pz] +xref: EC:2.7.1.140 +xref: MetaCyc:RXN-7186 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0102733 +name: typhasterol C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor." [GOC:pz, PMID:17138693] +xref: MetaCyc:RXN-719 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102734 +name: brassinolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-720 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102735 +name: trihydroxybenzophenone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide." [GOC:pz, RHEA:35143] +xref: EC:2.3.1.220 +xref: MetaCyc:RXN-7481 +xref: RHEA:35143 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102737 +name: p-coumaroyltriacetic acid synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7577 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102738 +name: (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate." [GOC:pz] +xref: MetaCyc:RXN-7589 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102739 +name: (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide." [GOC:pz] +xref: MetaCyc:RXN-7591 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102740 +name: theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine." [EC:2.1.1.160, GOC:pz] +xref: EC:2.1.1.160 +xref: MetaCyc:RXN-7599 +xref: RHEA:20944 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102741 +name: paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine." [EC:2.1.1.160, GOC:pz] +xref: EC:2.1.1.160 +xref: MetaCyc:RXN-7601 +xref: RHEA:10280 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102742 +name: R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP." [EC:1.1.1.237, GOC:pz] +xref: EC:1.1.1.237 +xref: MetaCyc:RXN-7632 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102743 +name: eriodictyol,NADPH:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7653 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102744 +name: all-trans-geranyl-geranyl diphosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7658 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102745 +name: dihydrogeranylgeranyl-PP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7659 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102746 +name: tetrahydrogeranylgeranyl-PP reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7660 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102747 +name: chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid." [EC:2.5.1.-, GOC:pz] +xref: MetaCyc:RXN-7663 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102748 +name: geranylgeranyl-chlorophyll a reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7664 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102749 +name: dihydrogeranylgeranyl-chlorophyll a reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7665 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102750 +name: tetrahydrogeranylgeranyl-chlorophyll a reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7666 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102751 +name: UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+." [EC:2.4.1.186, GOC:pz] +xref: EC:2.4.1.186 +xref: MetaCyc:RXN-7667 +xref: RHEA:56560 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102752 +name: 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) +namespace: molecular_function +def: "Catalysis of the reaction: a glucosylated glycogenin = a glycogen." [EC:2.4.1.18, GOC:pz] +xref: EC:2.4.1.18 +xref: MetaCyc:RXN-7669 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102753 +name: chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid." [EC:2.5.1.-, GOC:pz] +xref: MetaCyc:RXN-7673 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102754 +name: chlorophyllide-b:phytyl-diphosphate phytyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid." [EC:2.5.1.-, GOC:pz] +xref: MetaCyc:RXN-7674 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102755 +name: gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-7680 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102756 +name: very-long-chain 3-ketoacyl-CoA synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA." [GOC:pz, RHEA:32727] +xref: EC:2.3.1.199 +xref: MetaCyc:RXN-7697 +xref: RHEA:32727 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102757 +name: NADPH phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN-7703 +xref: RHEA:60664 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0102758 +name: very-long-chain enoyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA." [EC:1.3.1.93, GOC:pz] +xref: EC:1.3.1.93 +xref: MetaCyc:RXN-7711 +xref: RHEA:14473 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102759 +name: campestanol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-773 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102760 +name: 6-deoxocathasterone hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-774 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102761 +name: eriodictyol 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-7753 +xref: RHEA:60948 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102762 +name: eriodictyol 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-7754 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102763 +name: phytyl-P kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate." [EC:2.7.4.-, GOC:pz] +xref: MetaCyc:RXN-7763 +xref: RHEA:38099 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor + +[Term] +id: GO:0102764 +name: 6-deoxotyphasterol C-23 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor." [EC:1.14.-.-, GOC:pz] +xref: MetaCyc:RXN-777 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0102765 +name: UDP-D-apiose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide." [EC:4.1.1.-, GOC:pz] +xref: MetaCyc:RXN-7770 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:0102766 +name: naringenin 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.232, GOC:pz] +xref: EC:2.1.1.232 +xref: MetaCyc:RXN-7773 +xref: RHEA:31539 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102767 +name: flavanone 4'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine." [EC:2.1.1.231, GOC:pz] +xref: EC:2.1.1.231 +xref: MetaCyc:RXN-7777 +xref: RHEA:31743 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102768 +name: anthocyanidin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-7785 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102769 +name: dihydroceramide glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine." [EC:2.4.1.80, GOC:pz] +xref: EC:2.4.1.80 +xref: MetaCyc:RXN-7793 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102770 +name: inositol phosphorylceramide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol." [EC:2.7.1.-, GOC:pz] +xref: MetaCyc:RXN-7795 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0102771 +name: sphingolipid very long chain fatty acid alpha-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7796 +xref: RHEA:46512 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102772 +name: sphingolipid long-chain base 4-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P)." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7797 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102773 +name: dihydroceramide kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate." [EC:2.7.1.138, GOC:pz] +xref: EC:2.7.1.138 +xref: MetaCyc:RXN-7799 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0102774 +name: p-coumaroyltriacetic acid lactone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7822 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102775 +name: 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7826 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102776 +name: UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-7828 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102777 +name: caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-)." [EC:2.3.1.153, GOC:pz] +xref: EC:2.3.1.153 +xref: MetaCyc:RXN-7842 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102778 +name: Delta9-tetrahydrocannabinolate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide." [GOC:pz, RHEA:34135] +xref: EC:1.21.3.7 +xref: MetaCyc:RXN-7854 +xref: RHEA:34135 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0102779 +name: cannabidiolate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide." [EC:1.21.3.8, GOC:pz] +xref: EC:1.21.3.8 +xref: MetaCyc:RXN-7855 +xref: RHEA:34411 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0102780 +name: sitosterol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7876 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102781 +name: isofucosterol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7877 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102782 +name: cholestanol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-7878 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102783 +name: beta-carotene oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [EC:1.13.11.-, GOC:pz] +xref: MetaCyc:RXN-7883 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102784 +name: lutein oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [EC:1.13.11.-, GOC:pz] +xref: MetaCyc:RXN-7884 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102785 +name: violaxanthin oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial." [GOC:pz, PMID:11316814] +xref: MetaCyc:RXN-7886 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102786 +name: stearoyl-[acp] desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin." [EC:1.14.19.2, GOC:pz] +xref: EC:1.14.19.2 +xref: MetaCyc:RXN-7903 +xref: RHEA:11776 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102787 +name: caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7997 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102788 +name: 4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-7998 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102789 +name: UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8005 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102790 +name: cyanidin 5,3-O-glycosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8006 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102791 +name: sulfuretin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O." [EC:1.21.3.6, GOC:pz] +xref: EC:1.21.3.6 +xref: MetaCyc:RXN-8008 +is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor + +[Term] +id: GO:0102792 +name: sinapaldehyde:NAD(P)+ oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH." [EC:1.2.1.-, GOC:pz] +xref: MetaCyc:RXN-8014 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102793 +name: soyasapogenol B glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate." [EC:2.4.1.262, GOC:pz] +xref: EC:2.4.1.262 +xref: MetaCyc:RXN-8086 +xref: RHEA:31475 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102794 +name: cinnamaldehyde:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide." [EC:1.2.3.9, GOC:pz] +xref: EC:1.2.3.9 +xref: MetaCyc:RXN-8089 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0102795 +name: 1-naphthaldehyde:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide." [EC:1.2.3.9, GOC:pz] +xref: EC:1.2.3.9 +xref: MetaCyc:RXN-8090 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0102796 +name: protocatechualdehyde:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide." [EC:1.2.3.9, GOC:pz] +xref: EC:1.2.3.9 +xref: MetaCyc:RXN-8091 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0102797 +name: geranial:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide." [EC:1.2.3.1, GOC:pz] +xref: EC:1.2.3.1 +xref: MetaCyc:RXN-8093 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0102798 +name: heptaldehyde:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide." [EC:1.2.3.1, GOC:pz] +xref: EC:1.2.3.1 +xref: MetaCyc:RXN-8094 +is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor + +[Term] +id: GO:0102799 +name: glucosinolate glucohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides." [EC:3.2.1.147, GOC:pz] +xref: EC:3.2.1.147 +xref: MetaCyc:RXN-8134 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102800 +name: caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8138 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102801 +name: anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A." [GOC:pz, RHEA:35515] +xref: EC:2.3.1.214 +xref: MetaCyc:RXN-8139 +xref: RHEA:35515 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102802 +name: thebaine 6-O-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.31, GOC:pz] +xref: EC:1.14.11.31 +xref: MetaCyc:RXN-8147 +xref: RHEA:27477 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102803 +name: thebane O-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.32, GOC:pz] +xref: EC:1.14.11.32 +xref: MetaCyc:RXN-8149 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102804 +name: oripavine 6-O-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.31, GOC:pz] +xref: EC:1.14.11.31 +xref: MetaCyc:RXN-8151 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102805 +name: codeine O-demethylase activity +namespace: molecular_function +def: "Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide." [EC:1.14.11.32, GOC:pz] +xref: EC:1.14.11.32 +xref: MetaCyc:RXN-8152 +xref: RHEA:27413 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102806 +name: 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8170 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102807 +name: cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8176 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102808 +name: pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8177 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102809 +name: delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8178 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102810 +name: glutarate-semialdehyde dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+." [EC:1.2.1.-, GOC:pz] +xref: MetaCyc:RXN-8182 +xref: RHEA:57832 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102811 +name: geraniol 10-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O." [EC:1.14.14.83, GOC:pz] +xref: EC:1.14.14.83 +xref: MetaCyc:RXN-8197 +xref: RHEA:32495 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102812 +name: 4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8204 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102813 +name: UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8205 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102814 +name: caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8232 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102815 +name: caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A." [EC:2.3.1.153, GOC:pz] +xref: EC:2.3.1.153 +xref: MetaCyc:RXN-8233 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102816 +name: UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP." [EC:2.4.1.298, GOC:pz] +xref: EC:2.4.1.298 +xref: MetaCyc:RXN-8234 +xref: RHEA:35423 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102817 +name: caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8235 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102818 +name: lycopene cleavage oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde." [EC:1.13.12.-, GOC:pz] +xref: MetaCyc:RXN-8236 +is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) + +[Term] +id: GO:0102819 +name: bixin aldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+." [EC:1.2.1.-, GOC:pz] +xref: MetaCyc:RXN-8237 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102820 +name: norbixin methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-8238 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102821 +name: bixin methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-8239 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102822 +name: quercetin 3'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine." [EC:2.1.1.42, GOC:pz] +xref: EC:2.1.1.42 +xref: MetaCyc:RXN-8262 +xref: RHEA:55332 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102823 +name: kaempferol-3-rhamnoside-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8266 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102824 +name: UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8267 +xref: RHEA:61160 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102825 +name: quercetin 3-O-rhamnoside-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8268 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102826 +name: kaempferol-3-glucoside-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8270 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102827 +name: galactosylononitol-raffinose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol." [EC:2.4.1.67, GOC:pz] +xref: MetaCyc:RXN-8282 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102828 +name: stachyose galactinol:verbascose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8284 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102829 +name: ajugose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8285 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102830 +name: verbascose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose." [GOC:pz, PMID:12060258] +xref: MetaCyc:RXN-8286 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102831 +name: stachyose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose." [GOC:pz, PMID:12060258] +xref: MetaCyc:RXN-8287 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102832 +name: verbascose galactinol:ajugose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol." [GOC:pz, PMID:11675396] +xref: MetaCyc:RXN-8288 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102833 +name: sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8292 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102834 +name: 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8294 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102835 +name: 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8295 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102836 +name: 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8296 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102837 +name: 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8297 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102838 +name: 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8298 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102839 +name: 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8299 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102840 +name: 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8301 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102841 +name: 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:11607123] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8302 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102842 +name: 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46412] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8303 +xref: RHEA:46412 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102843 +name: 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46756] +xref: EC:1.14.19.42 +xref: MetaCyc:RXN-8304 +xref: RHEA:46756 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102844 +name: 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8305 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102845 +name: 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8307 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102846 +name: 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8308 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102847 +name: 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8309 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102848 +name: 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8310 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102849 +name: 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8314 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102850 +name: 1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46376] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8316 +xref: RHEA:46376 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102851 +name: 1-18:2-2-16:0-phosphatidylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.43 +xref: MetaCyc:RXN-8318 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102852 +name: 1-18:3-2-16:0-phosphatidylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8319 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102853 +name: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8320 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102854 +name: 1-18:2-2-18:1-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8321 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102855 +name: 1-18:1-2-18:2-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46332] +xref: EC:1.14.19.22 +xref: MetaCyc:RXN-8322 +xref: RHEA:46332 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102856 +name: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.25 +xref: MetaCyc:RXN-8323 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102857 +name: 1-18:1-2-18:3-phosphatidylcholinedesaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.22 +xref: MetaCyc:RXN-8324 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102858 +name: 1-18:2-2-18:3-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8325 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102859 +name: 1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, RHEA:46404] +xref: EC:1.14.19.25 +xref: MetaCyc:RXN-8326 +xref: RHEA:46404 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102860 +name: 1-18:1-2-18:2-phosphatidylcholine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:1-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.22 +xref: MetaCyc:RXN-8327 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102861 +name: 1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.22 +xref: MetaCyc:RXN-8328 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102862 +name: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming) +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.25 +xref: MetaCyc:RXN-8329 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102863 +name: 1-18:3-2-18:1-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8330 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102864 +name: 1-18:3-2-18:2-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8331 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102865 +name: delta6-acyl-lipid desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O." [GOC:pz, PMID:10848999, RHEA:46536] +xref: EC:1.14.19.38 +xref: MetaCyc:RXN-8343 +xref: RHEA:46536 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102866 +name: di-homo-gamma-linolenate delta5 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-8346 +xref: RHEA:46260 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102867 +name: molybdenum cofactor sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O." [EC:2.8.1.9, GOC:pz] +xref: EC:2.8.1.9 +xref: MetaCyc:RXN-8351 +xref: RHEA:42636 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0102868 +name: 24-epi-campsterol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8352 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102869 +name: 6-hydroxyflavone-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8354 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102870 +name: 7-hydroxyflavone-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8355 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102871 +name: 1-16:0-2-18:1-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:475773] +xref: EC:1.14.19.22 +xref: MetaCyc:RXN-8360 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102872 +name: 1-16:0-2-18:2-phosphatidylcholine desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:15538555, PMID:8102138] +xref: EC:1.14.19.25 +xref: MetaCyc:RXN-8361 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102873 +name: 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:7948918, PMID:8066133] +xref: EC:1.14.19.23 +xref: MetaCyc:RXN-8363 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102874 +name: 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz, PMID:17064923] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8365 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102875 +name: 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor." [GOC:pz] +xref: EC:1.14.19.35 +xref: MetaCyc:RXN-8366 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102876 +name: psoralen synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O." [EC:1.14.14.141, GOC:pz] +xref: EC:1.14.14.141 +xref: MetaCyc:RXN-8386 +xref: RHEA:19281 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102877 +name: alpha-copaene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid." [EC:4.2.3.133, GOC:pz] +xref: EC:4.2.3.133 +xref: MetaCyc:RXN-8416 +xref: RHEA:33991 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102878 +name: (+)-alpha-barbatene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid." [EC:4.2.3.69, GOC:pz] +xref: EC:4.2.3.69 +xref: MetaCyc:RXN-8417 +xref: RHEA:29499 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102879 +name: (+)-thujopsene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid." [GOC:pz, RHEA:30375] +xref: EC:4.2.3.79 +xref: MetaCyc:RXN-8418 +xref: RHEA:30375 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102880 +name: isobazzanene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8419 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102881 +name: (+)-beta-barbatene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid." [GOC:pz, PMID:15918888, PMID:16297850] +xref: MetaCyc:RXN-8421 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102882 +name: beta-acoradiene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8423 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102883 +name: (+)-beta-chamigrene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid." [EC:4.2.3.78, GOC:pz] +xref: EC:4.2.3.78 +xref: MetaCyc:RXN-8424 +xref: RHEA:30379 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102884 +name: alpha-zingiberene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid." [EC:4.2.3.65, GOC:pz] +xref: EC:4.2.3.65 +xref: MetaCyc:RXN-8425 +xref: RHEA:28643 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102885 +name: alpha-cuprenene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid." [EC:4.2.3.95, GOC:pz] +xref: EC:4.2.3.95 +xref: MetaCyc:RXN-8426 +xref: RHEA:32027 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102886 +name: alpha-chamigrene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8428 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102887 +name: beta-sesquiphellandrene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid." [EC:4.2.3.123, GOC:pz] +xref: EC:4.2.3.123 +xref: MetaCyc:RXN-8430 +xref: RHEA:32699 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102888 +name: delta-cuprenene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8431 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102889 +name: beta-elemene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8432 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102890 +name: naringenin chalcone 4'-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+." [EC:2.4.1.286, GOC:pz] +xref: EC:2.4.1.286 +xref: MetaCyc:RXN-8453 +xref: RHEA:34291 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102891 +name: 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP." [EC:2.4.1.286, GOC:pz] +xref: EC:2.4.1.286 +xref: MetaCyc:RXN-8455 +xref: RHEA:34295 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102892 +name: betanidin 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8479 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102893 +name: betanidin 6-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8480 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102894 +name: UDPG:cyclo-DOPA 5-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP." [GOC:pz, PMID:15196939, PMID:15695438] +xref: MetaCyc:RXN-8481 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102895 +name: colneleate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O." [EC:4.2.1.121, GOC:pz] +xref: EC:4.2.1.121 +xref: MetaCyc:RXN-8496 +xref: RHEA:28174 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102896 +name: colnelenate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O." [EC:4.2.1.121, GOC:pz] +xref: MetaCyc:RXN-8498 +xref: RHEA:28178 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0102897 +name: abietadienal hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8510 +xref: RHEA:56928 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102898 +name: levopimaradienol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8517 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102899 +name: dehydroabietadienol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8532 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102900 +name: dehydroabietadienal hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8534 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102901 +name: isopimaradienol hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8536 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102902 +name: isopimaradienal hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-8538 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102903 +name: gamma-terpinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid." [GOC:pz, RHEA:32559] +xref: EC:4.2.3.114 +xref: MetaCyc:RXN-8547 +xref: RHEA:32559 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102904 +name: germacrene C synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid." [EC:4.2.3.60, GOC:pz] +xref: EC:4.2.3.60 +xref: MetaCyc:RXN-8561 +xref: RHEA:28302 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102905 +name: valencene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid." [EC:4.2.3.73, GOC:pz] +xref: EC:4.2.3.73 +xref: MetaCyc:RXN-8608 +xref: RHEA:29511 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102906 +name: 7-epi-alpha-selinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid." [EC:4.2.3.86, GOC:pz] +xref: EC:4.2.3.86 +xref: MetaCyc:RXN-8609 +xref: RHEA:30383 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102907 +name: sesquisabinene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene." [EC:4.2.3.-, GOC:pz] +xref: MetaCyc:RXN-8622 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102909 +name: alpha-ketoglutarate reductase activity (NADH-dependent) +namespace: molecular_function +def: "Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-8645 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102910 +name: dirigent protein activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O." [EC:1.10.3.-, GOC:pz] +xref: MetaCyc:RXN-8677 +is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor + +[Term] +id: GO:0102911 +name: (-)-secoisolariciresinol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH." [EC:1.1.1.331, GOC:pz] +xref: MetaCyc:RXN-8680 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102912 +name: (-)-lactol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH." [EC:1.1.1.331, GOC:pz] +xref: MetaCyc:RXN-8681 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102913 +name: 3-aminomethylindole N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-8686 +xref: RHEA:52268 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102914 +name: N-methyl-3-aminomethylindole N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-8687 +xref: RHEA:52272 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102915 +name: piperitol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O." [GOC:pz, PMID:16785429, RHEA:56776] +xref: EC:1.14.19.74 +xref: MetaCyc:RXN-8695 +xref: RHEA:56776 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102916 +name: sesamin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O." [GOC:pz, PMID:16785429] +xref: EC:1.14.19.74 +xref: MetaCyc:RXN-8696 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102917 +name: (S)-reticuline 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine." [GOC:pz, RHEA:10444] +xref: EC:2.1.1.291 +xref: MetaCyc:RXN-8700 +xref: RHEA:10444 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102918 +name: (R)-reticuline 7-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+." [GOC:pz, RHEA:38907] +xref: EC:2.1.1.291 +xref: MetaCyc:RXN-8701 +xref: RHEA:38907 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102919 +name: 5,6-dimethylbenzimidazole synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid." [EC:1.13.11.79, GOC:pz] +xref: EC:1.13.11.79 +xref: MetaCyc:RXN-8771 +xref: RHEA:27345 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0102920 +name: acyl coenzyme A: isopenicillin N acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate." [EC:2.3.1.164, GOC:pz] +xref: EC:2.3.1.164 +xref: MetaCyc:RXN-8809 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102921 +name: mannosylglycerate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP." [EC:2.4.1.269, GOC:pz] +xref: EC:2.4.1.269 +xref: MetaCyc:RXN-8849 +xref: RHEA:30639 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102922 +name: phenylpropanoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8857 +xref: RHEA:42488 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102923 +name: 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8859 +xref: RHEA:33687 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102924 +name: gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-886 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102925 +name: solanine UDP-galactose galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8875 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102926 +name: solanidine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8882 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102927 +name: beta-chaconine rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8883 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102928 +name: beta-solanine rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-8884 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102929 +name: lachrymatory factor synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide." [EC:5.3.-.-, GOC:pz] +xref: MetaCyc:RXN-8911 +is_a: GO:0016860 ! intramolecular oxidoreductase activity + +[Term] +id: GO:0102930 +name: 4-hydroxybenzoate geranyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid." [GOC:pz, RHEA:27854] +xref: EC:2.5.1.93 +xref: MetaCyc:RXN-8920 +xref: RHEA:27854 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups + +[Term] +id: GO:0102931 +name: (Z,E)-alpha- farnesene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid." [GOC:pz, PMID:17140613] +xref: MetaCyc:RXN-8931 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0102932 +name: pterocarpan reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-8936 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102933 +name: GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate." [GOC:pz, RHEA:36779] +xref: EC:2.6.1.102 +xref: MetaCyc:RXN-8953 +xref: RHEA:36779 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0102934 +name: costunolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP." [GOC:pz, RHEA:28230] +xref: EC:1.14.14.150 +xref: MetaCyc:RXN-8971 +xref: RHEA:28230 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102935 +name: gypsogenin-UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9012 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102936 +name: gypsogenate-UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9013 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102937 +name: 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP." [GOC:pz] +xref: MetaCyc:RXN-9014 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102938 +name: orcinol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine." [EC:2.1.1.6, GOC:pz] +xref: EC:2.1.1.6 +xref: MetaCyc:RXN-9017 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102939 +name: 3-methoxy-5-hydroxytoluene O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9018 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102940 +name: phloroglucinol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9020 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102941 +name: 3,5-dihydroxyanisole O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9021 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102942 +name: 3,5-dimethoxyphenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9022 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102943 +name: trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate." [GOC:pz, RHEA:28182] +xref: EC:5.3.3.17 +xref: MetaCyc:RXN-9031 +xref: RHEA:28182 +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0102944 +name: medicagenate UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9035 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102945 +name: soyasapogenol B UDP-glucosyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9037 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102946 +name: soyasapogenol E UDP-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9038 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102947 +name: (+)-delta-cadinene-8-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O." [GOC:pz] +xref: MetaCyc:RXN-9045 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102948 +name: luteolin C-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9081 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102949 +name: 1,2-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor." [GOC:pz, PMID:15220389] +xref: MetaCyc:RXN-9082 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102950 +name: indole-3-acetyl-valine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-9083 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102951 +name: indole-3-acetyl-phenylalanine synthetase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid." [EC:6.3.-.-, GOC:pz] +xref: MetaCyc:RXN-9084 +is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds + +[Term] +id: GO:0102952 +name: UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-91 +xref: RHEA:57708 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102953 +name: hypoglycin A gamma-glutamyl transpeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B." [EC:2.3.2.2, GOC:pz] +xref: EC:2.3.2.2 +xref: MetaCyc:RXN-9157 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0102954 +name: dalcochinase activity +namespace: molecular_function +def: "Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose." [GOC:pz, PMID:16814564] +xref: MetaCyc:RXN-9162 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0102955 +name: S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+." [GOC:pz, PMID:1444716, PMID:9045837, RHEA:33255] +xref: EC:2.1.1.163 +xref: MetaCyc:RXN-9191 +xref: RHEA:33255 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102956 +name: UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-92 +xref: RHEA:57712 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102960 +name: momilactone-A synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H." [GOC:pz, RHEA:25367] +xref: EC:1.1.1.295 +xref: MetaCyc:RXN-9290 +xref: RHEA:25367 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102961 +name: 4,4'-diapophytofluene desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2." [EC:1.3.8.-, GOC:pz] +xref: MetaCyc:RXN-9304 +xref: RHEA:31399 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102962 +name: 4,4'-diapo-zeta-carotene desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2." [EC:1.3.8.-, GOC:pz] +xref: MetaCyc:RXN-9305 +xref: RHEA:31403 +is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor + +[Term] +id: GO:0102963 +name: (S)-corytuberine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O." [GOC:pz, PMID:18230623, RHEA:51540] +xref: EC:1.14.19.51 +xref: MetaCyc:RXN-9314 +xref: RHEA:51540 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102964 +name: S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9315 +xref: RHEA:51524 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102965 +name: alcohol-forming fatty acyl-CoA reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol." [EC:1.2.1.84, GOC:pz] +xref: EC:1.2.1.84 +xref: MetaCyc:RXN-9344 +xref: RHEA:52716 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102966 +name: arachidoyl-CoA:1-dodecanol O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A." [EC:2.3.1.75, GOC:pz] +xref: EC:2.3.1.75 +xref: MetaCyc:RXN-9356 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102967 +name: 10-hydroxygeraniol oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+." [GOC:pz, RHEA:32607] +xref: MetaCyc:RXN-9367 +xref: RHEA:32607 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102968 +name: 10-hydroxygeranial oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [GOC:pz, RHEA:32611] +xref: MetaCyc:RXN-9369 +xref: RHEA:32611 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102969 +name: 10-oxogeraniol oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+." [GOC:pz, RHEA:32615] +xref: MetaCyc:RXN-9370 +xref: RHEA:32615 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102970 +name: 7-deoxyloganetic acid glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP." [EC:2.4.1.323, GOC:pz] +xref: EC:2.4.1.323 +xref: MetaCyc:RXN-9372 +xref: RHEA:39895 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102971 +name: phosphinothricin N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate." [EC:2.3.1.183, GOC:pz] +xref: EC:2.3.1.183 +xref: MetaCyc:RXN-9382 +xref: RHEA:12597 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102972 +name: gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-947 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0102973 +name: norsolorinate anthrone synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]." [EC:2.3.1.221, GOC:pz] +synonym: "norsolorinic acid synthase" EXACT [] +xref: EC:2.3.1.221 +xref: MetaCyc:RXN-9479 +xref: RHEA:35179 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102974 +name: hydroxyversicolorone reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH." [GOC:pz, RHEA:35691] +xref: EC:1.1.1.353 +xref: MetaCyc:RXN-9489 +xref: RHEA:35691 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102975 +name: versiconal hemiacetal acetate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH." [EC:1.1.1.353, GOC:pz] +xref: EC:1.1.1.353 +xref: MetaCyc:RXN-9490 +xref: RHEA:35695 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102976 +name: versiconal reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+." [EC:1.1.1.353, GOC:pz] +xref: EC:1.1.1.353 +xref: MetaCyc:RXN-9491 +xref: RHEA:35699 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102977 +name: nitrilotriacetate monooxygenase activity (FMN-dependent) +namespace: molecular_function +def: "Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN." [EC:1.14.14.10, GOC:pz] +xref: EC:1.14.14.10 +xref: MetaCyc:RXN-9508 +xref: RHEA:31359 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102978 +name: furaneol oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+." [EC:1.3.1.105, GOC:pz] +xref: EC:1.3.1.105 +xref: MetaCyc:RXN-9563 +xref: RHEA:39111 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102979 +name: homofuraneol oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-9564 +xref: RHEA:53944 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102980 +name: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-9565 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102981 +name: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-9567 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102982 +name: UDP-3-dehydro-alpha-D-glucose dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9578 +xref: RHEA:35755 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102983 +name: xylogalacturonan beta-1,3-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan." [EC:2.4.2.41, GOC:pz] +xref: EC:2.4.2.41 +xref: MetaCyc:RXN-9589 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0102984 +name: sulfoacetaldehyde dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+." [EC:1.2.1.73, GOC:pz] +xref: EC:1.2.1.73 +xref: MetaCyc:RXN-9592 +xref: RHEA:25637 +is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102985 +name: delta12-fatty-acid desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9." [GOC:pz, RHEA:25856] +xref: EC:1.14.19.6 +xref: MetaCyc:RXN-9601 +xref: RHEA:25856 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102986 +name: trehalose synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate." [EC:2.4.1.245, GOC:pz] +xref: EC:2.4.1.245 +xref: MetaCyc:RXN-9603 +xref: RHEA:47416 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102987 +name: palmitoleic acid delta 12 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-9616 +xref: RHEA:45096 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102988 +name: 9,12-cis-hexadecadienoic acid delta 15 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-9617 +xref: RHEA:46232 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102989 +name: 5-pentadecatrienylresorcinol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide." [EC:2.3.1.-, GOC:pz] +xref: MetaCyc:RXN-9618 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0102990 +name: 5-n-alk(en)ylresorcinol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN-9619 +xref: RHEA:26325 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0102991 +name: myristoyl-CoA hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A." [EC:3.1.2.2, GOC:pz] +xref: EC:3.1.2.2 +xref: MetaCyc:RXN-9626 +xref: RHEA:40119 +is_a: GO:0016790 ! thiolester hydrolase activity + +[Term] +id: GO:0102992 +name: 2-methylbutyronitrile hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-9642 +xref: RHEA:51948 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102993 +name: linolenate delta15 desaturase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor." [EC:1.14.19.-, GOC:pz] +xref: MetaCyc:RXN-9667 +xref: RHEA:46408 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0102995 +name: angelicin synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O." [EC:1.14.14.148, GOC:pz] +xref: EC:1.14.14.148 +xref: MetaCyc:RXN-9689 +xref: RHEA:27481 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0102996 +name: beta,beta digalactosyldiacylglycerol galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol." [EC:2.4.1.184, GOC:pz] +xref: EC:2.4.1.184 +xref: MetaCyc:RXN-9721 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0102997 +name: progesterone 5beta- reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP." [EC:1.3.1.-, GOC:pz] +xref: MetaCyc:RXN-9726 +is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0102998 +name: 4-sulfomuconolactone hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+." [EC:3.1.1.92, GOC:pz] +xref: EC:3.1.1.92 +xref: MetaCyc:RXN-9733 +xref: RHEA:33711 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0102999 +name: UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9743 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103000 +name: UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN-9748 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103001 +name: dimethylsulfoxide oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-9767 +xref: RHEA:57956 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103002 +name: 16-hydroxypalmitate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH." [GOC:pz] +xref: MetaCyc:RXN-9802 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103003 +name: oleate peroxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol." [EC:1.11.-.-, GOC:pz] +xref: MetaCyc:RXN-9804 +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:0103004 +name: 9,10-epoxystearate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-9805 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103005 +name: 9,10-epoxystearate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate." [EC:3.3.2.-, GOC:pz] +xref: MetaCyc:RXN-9806 +is_a: GO:0016803 ! ether hydrolase activity + +[Term] +id: GO:0103006 +name: 9,10-dihydroxystearate hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-9807 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103007 +name: indole-3-acetate carboxyl methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine." [EC:2.1.1.278, GOC:pz] +xref: EC:2.1.1.278 +xref: MetaCyc:RXN-9825 +xref: RHEA:36131 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0103008 +name: 4-chloro-2-methylphenoxyacetate oxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-9864 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103009 +name: 3-chlorotoluene monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXN-9908 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103010 +name: gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN-991 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103011 +name: mannosylfructose-phosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP." [EC:2.4.1.246, GOC:pz] +xref: EC:2.4.1.246 +xref: MetaCyc:RXN-9935 +xref: RHEA:26039 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103012 +name: ferredoxin-thioredoxin reductase activity +namespace: molecular_function +alt_id: GO:0030385 +def: "Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide." [GOC:pz, PMID:14769790, RHEA:42336] +synonym: "ferredoxin:thioredoxin reductase activity" EXACT [] +xref: EC:1.8.7.2 +xref: MetaCyc:RXN-9944 +xref: RHEA:42336 +is_a: GO:0016673 ! oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor + +[Term] +id: GO:0103014 +name: beta-keto ester reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-1941 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103015 +name: 4-amino-4-deoxy-L-arabinose transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate." [EC:2.4.2.43, GOC:pz] +xref: EC:2.4.2.43 +xref: MetaCyc:RXN0-2001 +xref: RHEA:35371 +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0103016 +name: tRNA-specific 2-thiouridylase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine." [GOC:pz, PMID:12949933] +xref: MetaCyc:RXN0-2023 +is_a: GO:0016874 ! ligase activity + +[Term] +id: GO:0103020 +name: 1-deoxy-D-xylulose kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP." [GOC:pz, PMID:11168365, PMID:16920870] +xref: MetaCyc:RXN0-382 +xref: RHEA:27990 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0103023 +name: ITPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate." [GOC:pz, PMID:16216582, RHEA:28330] +xref: EC:3.6.1.73 +xref: MetaCyc:RXN0-5073 +xref: RHEA:28330 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0103026 +name: fructose-1-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN0-5186 +xref: RHEA:35603 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0103027 +name: FMN phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate." [EC:3.1.3.-, GOC:pz] +xref: MetaCyc:RXN0-5187 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0103028 +name: murein hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide." [EC:4.2.2.-, GOC:pz] +xref: MetaCyc:RXN0-5190 +is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides + +[Term] +id: GO:0103030 +name: ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-5213 +xref: RHEA:35615 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103031 +name: L-Ala-D/L-Glu epimerase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate." [EC:5.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-5228 +xref: RHEA:28394 +is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives + +[Term] +id: GO:0103032 +name: tartronate semialdehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-5289 +xref: RHEA:18845 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103033 +name: beta-galactosidase activity (lactose isomerization) +namespace: molecular_function +def: "Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose." [EC:5.4.1.-, GOC:pz] +xref: MetaCyc:RXN0-5363 +is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups + +[Term] +id: GO:0103035 +name: NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP." [EC:1.6.5.-, GOC:pz] +xref: MetaCyc:RXN0-5387 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0103036 +name: NADH:menaquinone oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol." [GOC:pz] +xref: MetaCyc:RXN0-5388 +is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor + +[Term] +id: GO:0103037 +name: L-glyceraldehyde 3-phosphate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-5410 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103039 +name: protein methylthiotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor." [EC:2.8.4.4, GOC:pz] +xref: EC:2.8.4.4 +xref: MetaCyc:RXN0-6366 +xref: RHEA:37087 +is_a: GO:0035596 ! methylthiotransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0103040 +name: aldose sugar dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor." [EC:1.1.5.-, GOC:pz] +xref: MetaCyc:RXN0-6371 +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0103041 +name: thiosulfate-thioredoxin sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin." [EC:2.8.1.-, GOC:pz] +xref: MetaCyc:RXN0-6385 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:0103042 +name: 4-hydroxy-L-threonine aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine." [GOC:pz, RHEA:28779] +xref: MetaCyc:RXN0-6563 +xref: RHEA:28779 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0103043 +name: 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate." [EC:3.1.4.55, GOC:pz] +xref: EC:3.1.4.55 +xref: MetaCyc:RXN0-6710 +xref: RHEA:34795 +is_a: GO:0008081 ! phosphoric diester hydrolase activity + +[Term] +id: GO:0103044 +name: ribosomal protein S6 glutamate-glutamate ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate." [EC:6.3.2.-, GOC:pz] +xref: MetaCyc:RXN0-6726 +is_a: GO:0018169 ! ribosomal S6-glutamic acid ligase activity + +[Term] +id: GO:0103045 +name: methione N-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+." [EC:2.3.1.1, GOC:pz] +xref: EC:2.3.1.1 +xref: MetaCyc:RXN0-6948 +xref: RHEA:44144 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0103046 +name: alanylglutamate dipeptidase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate." [EC:3.4.13.18, GOC:pz] +xref: EC:3.4.13.18 +xref: MetaCyc:RXN0-6981 +is_a: GO:0016805 ! dipeptidase activity + +[Term] +id: GO:0103047 +name: methyl beta-D-glucoside 6-phosphate glucohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol." [EC:3.2.1.86, GOC:pz] +xref: EC:3.2.1.86 +xref: MetaCyc:RXN0-6994 +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0103048 +name: tRNA m2A37 methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA." [EC:2.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-7007 +is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity + +[Term] +id: GO:0103050 +name: isobutyraldehyde reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: isobutanol + NADP <=> isobutyraldehyde + NADPH + H+." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXN0-7119 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103054 +name: gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN1F-162 +xref: RHEA:60776 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103055 +name: gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN1F-163 +xref: RHEA:60780 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103056 +name: gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN1F-167 +xref: RHEA:60800 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103057 +name: gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate." [EC:1.14.11.-, GOC:pz] +xref: MetaCyc:RXN1F-169 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0103058 +name: kaempferol 3-glucoside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN1F-443 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103059 +name: UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-)." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN1F-474 +xref: RHEA:61164 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103060 +name: kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXN1F-475 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103061 +name: trans-methoxy-C60-meroacyl-AMP ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]." [GOC:pz, PMID:15042094] +xref: MetaCyc:RXN1G-4141 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0103062 +name: cis-keto-C60-meroacyl-AMP ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN1G-4142 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0103063 +name: trans-keto-C61-meroacyl-AMP ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]." [EC:6.2.1.-, GOC:pz] +xref: MetaCyc:RXN1G-4143 +is_a: GO:0016878 ! acid-thiol ligase activity + +[Term] +id: GO:0103064 +name: inositol phosphorylceramide mannosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+." [GOC:pz, RHEA:64596] +xref: EC:2.4.1.370 +xref: https://github.com/geneontology/go-ontology/issues/21803 +xref: MetaCyc:RXN3O-663 +xref: RHEA:64596 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103066 +name: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H." [EC:1.1.1.170, GOC:pz] +xref: EC:1.1.1.170 +xref: MetaCyc:RXN66-18 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103067 +name: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity +namespace: molecular_function +def: "Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H." [GOC:pz, RHEA:33447] +xref: EC:1.1.1.170 +xref: MetaCyc:RXN66-23 +xref: RHEA:33447 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103068 +name: leukotriene C4 gamma-glutamyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid." [GOC:pz, PMID:1676842, PMID:9139674] +xref: EC:2.3.2.2 +xref: MetaCyc:RXN66-336 +is_a: GO:0016755 ! aminoacyltransferase activity + +[Term] +id: GO:0103069 +name: 17-hydroxyprogesterone 21-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:pz, RHEA:50308] +xref: MetaCyc:RXN66-356 +xref: RHEA:50308 +is_a: GO:0004509 ! steroid 21-monooxygenase activity + +[Term] +id: GO:0103071 +name: 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA <=> formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde." [EC:4.1.-.-, GOC:pz] +xref: MetaCyc:RXN66-471 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0103072 +name: straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde." [EC:4.1.-.-, GOC:pz] +xref: MetaCyc:RXN66-475 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:0103073 +name: anandamide amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+)." [EC:3.5.1.99, GOC:pz] +xref: EC:3.5.1.99 +xref: MetaCyc:RXN6666-2 +xref: RHEA:26136 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0103074 +name: glucose-6-phosphate 3-dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate." [GOC:pz, RHEA:37547] +xref: EC:1.1.1.361 +xref: MetaCyc:RXN8J2-136 +xref: RHEA:37547 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103075 +name: indole-3-pyruvate monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O." [EC:1.14.13.168, GOC:pz] +xref: EC:1.14.13.168 +xref: MetaCyc:RXNDQC-2 +xref: RHEA:34331 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103077 +name: quercetin 3-glucoside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4161 +xref: RHEA:61188 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103078 +name: quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4162 +xref: RHEA:61184 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103079 +name: 2-(3'-methylthio)propylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A." [EC:2.3.3.-, GOC:pz] +xref: MetaCyc:RXNQT-4163 +xref: RHEA:25605 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0103080 +name: methylthiopropylmalate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate." [EC:5.4.4.-, GOC:pz] +xref: MetaCyc:RXNQT-4164 +xref: RHEA:50644 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0103081 +name: methylthiopropylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(3'-methylthio)propylmalate <=> H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4165 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103082 +name: 2-(4'-methylthio)butylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A." [EC:2.3.3.-, GOC:pz] +xref: MetaCyc:RXNQT-4166 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0103083 +name: methylthiobutylmalate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate." [EC:5.4.4.-, GOC:pz] +xref: MetaCyc:RXNQT-4167 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0103084 +name: methylthiobutylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(4'-methylthio)butylmalate <=> H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4168 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103085 +name: 2-(5'-methylthio)pentylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A." [EC:2.3.3.-, GOC:pz] +xref: MetaCyc:RXNQT-4169 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0103086 +name: methylthiopentylmalate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate." [EC:5.4.4.-, GOC:pz] +xref: MetaCyc:RXNQT-4170 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0103087 +name: methylthiopentylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(5'-methylthio)pentylmalate <=> H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4171 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103088 +name: 2-(6'-methylthio)hexylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A." [EC:2.3.3.-, GOC:pz] +xref: MetaCyc:RXNQT-4172 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0103089 +name: methylthiohexylmalate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate." [EC:5.4.4.-, GOC:pz] +xref: MetaCyc:RXNQT-4173 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0103090 +name: methylthiohexylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(6'-methylthio)hexylmalate <=> H+ + 2-oxo-9-methylthiononanoate + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4174 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103091 +name: 2-(7'-methylthio)heptylmalate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A." [EC:2.3.3.-, GOC:pz] +xref: MetaCyc:RXNQT-4175 +is_a: GO:0046912 ! acyltransferase, acyl groups converted into alkyl on transfer + +[Term] +id: GO:0103092 +name: methylthioalkylmalate isomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate." [EC:5.4.4.-, GOC:pz] +xref: MetaCyc:RXNQT-4176 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0103093 +name: methylthioalkylmalate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-(7'-methylthio)heptylmalate <=> H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide." [EC:1.1.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4178 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0103096 +name: CYP79F1 dihomomethionine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXNQT-4309 +xref: RHEA:32719 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103097 +name: CYP79F1 trihomomethionine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXNQT-4310 +xref: RHEA:32723 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103098 +name: CYP79F1 tetrahomomethionine monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime." [EC:1.14.13.-, GOC:pz] +xref: MetaCyc:RXNQT-4311 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0103099 +name: UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXNQT-4324 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103100 +name: UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-)." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXNQT-4325 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103101 +name: UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXNQT-4326 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103102 +name: UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXNQT-4327 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103103 +name: UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+." [EC:2.4.1.195, GOC:pz] +xref: EC:2.4.1.195 +xref: MetaCyc:RXNQT-4328 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103104 +name: 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate." [EC:2.8.2.-, GOC:pz] +xref: MetaCyc:RXNQT-4331 +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:0103105 +name: 2-oxo-6-methylthiohexanoate aminotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate." [EC:2.6.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4345 +is_a: GO:0008483 ! transaminase activity + +[Term] +id: GO:0103106 +name: brassinolide 23-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4397 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103107 +name: castasterone 23-O-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+." [EC:2.4.1.-, GOC:pz] +xref: MetaCyc:RXNQT-4398 +is_a: GO:0016758 ! hexosyltransferase activity + +[Term] +id: GO:0103111 +name: D-glucosamine PTS permease activity +namespace: molecular_function +def: "Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine." [EC:2.7.1.69, GOC:pz] +xref: EC:2.7.1.69 +xref: MetaCyc:TRANS-RXN-167A +xref: RHEA:37359 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0103113 +name: obsolete glucosyl-oleandomycin-exporting ATPase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: glucosyl-oleandomycin + ATP + H2O <=> glucosyl-oleandomycin + ADP + hydrogenphosphate + H+." [EC:3.6.3.-, GOC:pz] +comment: This term was obsoleted because it represents a substrate-specific version of the general term GO:0008559 ATPase-coupled xenobiotic transmembrane transporter activity. +xref: MetaCyc:TRANS-RXN-220 +is_obsolete: true + +[Term] +id: GO:0103116 +name: ABC-type D-galactofuranose transporter +namespace: molecular_function +def: "Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+." [GOC:pz, PMID:19744923, RHEA:61716] +synonym: "alpha-D-galactofuranose transporter activity" EXACT [] +synonym: "ATP-dependent alpha-D-galactofuranose transporter activity" EXACT [] +synonym: "ATPase-coupled alpha-D-galactofuranose transporter activity" RELATED [] +xref: EC:7.5.2.9 +xref: MetaCyc:TRANS-RXN0-491 +xref: RHEA:61716 +is_a: GO:0005354 ! galactose transmembrane transporter activity +is_a: GO:0015407 ! ABC-type monosaccharide transporter activity + +[Term] +id: GO:0103117 +name: UDP-3-O-acyl-N-acetylglucosamine deacetylase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate." [EC:3.5.1.108, GOC:pz] +xref: EC:3.5.1.108 +xref: MetaCyc:UDPACYLGLCNACDEACETYL-RXN +xref: RHEA:25209 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0103118 +name: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity +namespace: molecular_function +alt_id: GO:0043764 +def: "Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]." [EC:2.3.1.191, GOC:pz] +synonym: "UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity" RELATED [] +xref: EC:2.3.1.191 +xref: MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN +xref: RHEA:17817 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0104004 +name: cellular response to environmental stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus." [GOC:dos] +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:0104005 +name: obsolete hijacked molecular function +namespace: molecular_function +def: "OBSOLETE. A function that was not selected for in the evolution of an organism, but arises from co-option by another organism, e.g. a human protein used as a virus receptor." [GOC:pdt] +comment: This term was obsoleted because it was an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0106001 +name: intestinal hexose absorption +namespace: biological_process +def: "Uptake of hexoses, notably D-glucose, fructose, and galactose, into the blood by absorption from the small intestine." [GOC:hjd] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0050892 ! intestinal absorption + +[Term] +id: GO:0106002 +name: mCRD-mediated mRNA stability complex +namespace: cellular_component +def: "A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP." [GOC:bhm, PMID:11051545] +comment: This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA. +synonym: "major coding region determinant of instability-mediated mRNA stability complex" EXACT [] +synonym: "major coding region instability determinant-mediated mRNA stability complex" EXACT [] +synonym: "major coding region instability determinant-poly(A)-bridging complex" EXACT [] +synonym: "major coding-region determinant of instability - poly(A) tail-bridging complex" EXACT [] +synonym: "mCRD-poly(A)-bridging complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0106003 +name: amyloid-beta complex +namespace: cellular_component +def: "Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease." [GOC:bhm, PMID:18568035] +comment: An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay). +synonym: "Abeta complex" EXACT [] +synonym: "Abeta-derived diffusible ligand complex" NARROW [] +synonym: "ADDL complex" NARROW [] +synonym: "amyloid beta complex" EXACT [] +synonym: "amyloid beta dimer" NARROW [] +synonym: "amyloid beta heterodimer" NARROW [] +synonym: "amyloid beta heterooligomer" NARROW [] +synonym: "amyloid beta heterotrimer" NARROW [] +synonym: "amyloid beta homodimer" NARROW [] +synonym: "amyloid beta homooligomer" NARROW [] +synonym: "amyloid beta homotrimer" NARROW [] +synonym: "amyloid beta oligomer" NARROW [] +synonym: "amyloid beta trimer" NARROW [] +synonym: "amyloid-beta protein 40 complex" NARROW [] +synonym: "amyloid-beta protein 40/42 complex" NARROW [] +synonym: "amyloid-beta protein 42 complex" NARROW [] +synonym: "beta amyloid complex" EXACT [] +synonym: "beta-amyloid complex" EXACT [] +synonym: "betaA complex" EXACT [] +synonym: "heterodimer of amyloid beta protein" NARROW [] +synonym: "heterooligomer of amyloid beta protein" NARROW [] +synonym: "heterotrimer of amyloid beta protein" NARROW [] +synonym: "homodimer of amyloid beta protein" NARROW [] +synonym: "homooligomer of amyloid beta protein" NARROW [] +synonym: "homotrimer of amyloid beta protein" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0106004 +name: tRNA (guanine-N7)-methylation +namespace: biological_process +def: "The process whereby a guanine in a tRNA is methylated at the N7 position of guanine." [GOC:hjd, PMID:17382321] +is_a: GO:0030488 ! tRNA methylation +is_a: GO:0036265 ! RNA (guanine-N7)-methylation + +[Term] +id: GO:0106005 +name: RNA 5'-cap (guanine-N7)-methylation +namespace: biological_process +def: "The process whereby a guanine in 5-cap is methylated at the N7 position of guanine." [GOC:hjd] +is_a: GO:0036265 ! RNA (guanine-N7)-methylation +relationship: part_of GO:0009452 ! 7-methylguanosine RNA capping + +[Term] +id: GO:0106006 +name: cytoskeletal protein-membrane anchor activity +namespace: molecular_function +alt_id: GO:0140362 +def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location." [PMID:25736293, PMID:30840879] +synonym: "BAR domain adaptor" NARROW [] +synonym: "cytoskeletal protein membrane adaptor" BROAD [] +synonym: "cytoskeletal protein membrane anchor activity" BROAD [] +synonym: "cytoskeletal protein membrane tether activity" BROAD [] +synonym: "cytoskeletal protein-membrane adaptor activity" BROAD [] +synonym: "F-BAR domain adaptor" NARROW [] +synonym: "membrane-cytoskeletal protein anchor activity" BROAD [] +synonym: "membrane-cytoskeletal protein tether activity" BROAD [] +synonym: "microtubule cortical anchor activity" NARROW [] +is_a: GO:0008093 ! cytoskeletal anchor activity +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0106007 +name: microtubule anchoring at cell cortex of cell tip +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex." [GOC:mah, PMID:25736293] +is_a: GO:0034453 ! microtubule anchoring + +[Term] +id: GO:0106008 +name: 2-oxoglutaramate amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3)." [EC:3.5.1.111, PMID:21288482] +xref: EC:3.5.1.111 +xref: RHEA:32963 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0106009 +name: (4S)-4-hydroxy-2-oxoglutarate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.42, GOC:hjd, PMID:1098660, PMID:1339418] +xref: EC:4.1.3.42 +xref: RHEA:35639 +is_a: GO:0016833 ! oxo-acid-lyase activity + +[Term] +id: GO:0106011 +name: regulation of protein localization to medial cortex +namespace: biological_process +def: "Any process that regulates the localization of a protein to the medial cortex." [GOC:hjd] +is_a: GO:1901900 ! regulation of protein localization to cell division site +is_a: GO:1904776 ! regulation of protein localization to cell cortex +relationship: regulates GO:0071574 ! protein localization to medial cortex + +[Term] +id: GO:0106012 +name: positive regulation of protein localization to medial cortex +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to the medial cortex." [GOC:hjd, PMID:19474789] +is_a: GO:0106011 ! regulation of protein localization to medial cortex +is_a: GO:1904778 ! positive regulation of protein localization to cell cortex +relationship: positively_regulates GO:0071574 ! protein localization to medial cortex + +[Term] +id: GO:0106013 +name: negative regulation of protein localization to cell cortex of cell tip +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip." [GOC:vw, PMID:19474792] +is_a: GO:1990895 ! regulation of protein localization to cell cortex of cell tip + +[Term] +id: GO:0106014 +name: regulation of inflammatory response to wounding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:1903034 ! regulation of response to wounding +relationship: regulates GO:0090594 ! inflammatory response to wounding + +[Term] +id: GO:0106015 +name: negative regulation of inflammatory response to wounding +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0106014 ! regulation of inflammatory response to wounding +is_a: GO:1903035 ! negative regulation of response to wounding +relationship: negatively_regulates GO:0090594 ! inflammatory response to wounding + +[Term] +id: GO:0106016 +name: positive regulation of inflammatory response to wounding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0106014 ! regulation of inflammatory response to wounding +is_a: GO:1903036 ! positive regulation of response to wounding +relationship: positively_regulates GO:0090594 ! inflammatory response to wounding + +[Term] +id: GO:0106017 +name: phosphatidylinositol-3,4-bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity + +[Term] +id: GO:0106018 +name: phosphatidylinositol-3,5-bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity + +[Term] +id: GO:0106019 +name: phosphatidylinositol-4,5-bisphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate." [GOC:hjd] +is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity + +[Term] +id: GO:0106020 +name: regulation of vesicle docking +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vesicle docking." [PMID:22810233] +synonym: "regulation of vesicle to membrane docking" EXACT [] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0048278 ! vesicle docking + +[Term] +id: GO:0106021 +name: negative regulation of vesicle docking +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking." [PMID:22810233] +synonym: "negative regulation of vesicle to membrane docking" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0106020 ! regulation of vesicle docking +relationship: negatively_regulates GO:0048278 ! vesicle docking + +[Term] +id: GO:0106022 +name: positive regulation of vesicle docking +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vesicle docking." [PMID:22810233] +synonym: "positive regulation of vesicle to membrane docking" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0106020 ! regulation of vesicle docking +relationship: positively_regulates GO:0048278 ! vesicle docking + +[Term] +id: GO:0106023 +name: regulation of pupariation +namespace: biological_process +def: "Any process that modulates the onset of pupariation." [PMID:26510564] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0035073 ! pupariation + +[Term] +id: GO:0106024 +name: negative regulation of pupariation +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of onset of pupariation." [PMID:26510564] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:0106023 ! regulation of pupariation +relationship: negatively_regulates GO:0035073 ! pupariation + +[Term] +id: GO:0106025 +name: positive regulation of pupariation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of onset of pupariation." [GOC:hjd] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0106023 ! regulation of pupariation +relationship: positively_regulates GO:0035073 ! pupariation + +[Term] +id: GO:0106026 +name: Gly-tRNA(Ala) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala)." [PMID:28362257] +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0106027 +name: neuron projection organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite." [GOC:aruk, GOC:bc, PMID:11585923] +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0106028 +name: neuron projection retraction +namespace: biological_process +def: "The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:aruk, GOC:bc, PMID:11585923.] +synonym: "neuron projection disassembly" EXACT [] +is_a: GO:0106027 ! neuron projection organization + +[Term] +id: GO:0106029 +name: tRNA pseudouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:11095668] +synonym: "Mitochondrial tRNA pseudouridine(27/28) synthase" NARROW [EC:5.4.99.44] +synonym: "transfer ribonucleate pseudouridine synthetase activity" EXACT [] +synonym: "transfer RNA pseudouridine synthetase activity" EXACT [] +synonym: "tRNA pseudouridine(13) synthase" NARROW [EC:5.4.99.27] +synonym: "tRNA pseudouridine(31) synthase" NARROW [EC:5.4.99.42] +synonym: "tRNA pseudouridine(32) synthase" NARROW [EC:5.4.99.28] +synonym: "tRNA pseudouridine(38-40) synthase" NARROW [EC:5.4.99.12] +synonym: "tRNA pseudouridine(38/39) synthase" NARROW [EC:5.4.99.45] +synonym: "tRNA pseudouridine(55) synthase" NARROW [EC:5.4.99.25] +synonym: "tRNA pseudouridine(65) synthase" NARROW [EC:5.4.99.26] +synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] +synonym: "tRNA-pseudouridine synthase activity" EXACT [] +synonym: "tRNA-pseudouridine synthase I activity" NARROW [EC:5.4.99.12] +synonym: "tRNA-uridine isomerase activity" EXACT [] +synonym: "tRNA-uridine uracilmutase activity" EXACT [] +xref: EC:5.4.99.12 +xref: EC:5.4.99.25 +xref: EC:5.4.99.26 +xref: EC:5.4.99.27 +xref: EC:5.4.99.28 +xref: EC:5.4.99.42 +xref: EC:5.4.99.44 +xref: EC:5.4.99.45 +xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN +xref: RHEA:22376 +is_a: GO:0009982 ! pseudouridine synthase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0106030 +name: neuron projection fasciculation +namespace: biological_process +def: "The collection of neuronal projections into a bundle of rods, known as a fascicle." [GOC:aruk, GOC:bc., PMID:12761826] +is_a: GO:0031175 ! neuron projection development + +[Term] +id: GO:0106032 +name: snRNA pseudouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181] +is_a: GO:0009982 ! pseudouridine synthase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0106033 +name: spine synapse +namespace: cellular_component +def: "A type of synapse occurring between an axon and a dendritic spine." [PMID:15028757] +synonym: "dendritic spine synapse" EXACT [] +is_a: GO:0032279 ! asymmetric synapse + +[Term] +id: GO:0106034 +name: protein maturation by [2Fe-2S] cluster transfer +namespace: biological_process +def: "The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440] +is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer + +[Term] +id: GO:0106035 +name: protein maturation by [4Fe-4S] cluster transfer +namespace: biological_process +def: "The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [PMID:23615440] +is_a: GO:0097428 ! protein maturation by iron-sulfur cluster transfer + +[Term] +id: GO:0106036 +name: assembly of apicomedial cortex actomyosin +namespace: biological_process +def: "A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin." [PMID:28263180] +is_a: GO:0030866 ! cortical actin cytoskeleton organization +is_a: GO:0031032 ! actomyosin structure organization + +[Term] +id: GO:0106037 +name: apicomedial cortex +namespace: cellular_component +def: "The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell." [PMID:23831726, PMID:28263180] +synonym: "medioapical cortex" EXACT [] +is_a: GO:0045179 ! apical cortex + +[Term] +id: GO:0106038 +name: obsolete vesicle assembly +namespace: biological_process +def: "OBSOLETE. A process carried out at the cellular level, which results in the arrangement of constituent parts of a vesicle. Vesicle assembly begins with membrane bending (GO:0097753) and ends with fusion of the vesicle after vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166] +comment: This term was made obsolete because it is an exact synonym of 'membrane budding'. +synonym: "vesicle biosynthesis" EXACT [] +synonym: "vesicle formation" EXACT [] +is_obsolete: true + +[Term] +id: GO:0106039 +name: obsolete vesicle fusion involved in vesicle assembly +namespace: biological_process +def: "OBSOLETE. A process carried out at the cellular level, which is the final step in vesicle assembly. Vesicle fusion occurs when a newly assembled vesicle closes up, following vesicle vesicle scission (GO:0099050)." [GOC:aruk, GOC:bc, PMID:25898166] +comment: This term was made obsolete becausethat 'fusion' should only be used for two membranes getting joined together, whereas in this case it would be one membrane 'closing/sealing up'. +is_obsolete: true + +[Term] +id: GO:0106040 +name: regulation of GABA-A receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:0106041 +name: positive regulation of GABA-A receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] +is_a: GO:0106040 ! regulation of GABA-A receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:0106042 +name: negative regulation of GABA-A receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity." [PMID:24044036] +is_a: GO:0106040 ! regulation of GABA-A receptor activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:0106044 +name: guanine deglycation +namespace: biological_process +def: "The removal of a sugar or dicarbonyl from a glycated guanine." [PMID:28596309] +is_a: GO:0009117 ! nucleotide metabolic process + +[Term] +id: GO:0106045 +name: guanine deglycation, methylglyoxal removal +namespace: biological_process +def: "The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine." [PMID:28596309] +is_a: GO:0106044 ! guanine deglycation +is_a: GO:0140041 ! cellular detoxification of methylglyoxal + +[Term] +id: GO:0106046 +name: guanine deglycation, glyoxal removal +namespace: biological_process +def: "The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine." [PMID:28596309] +is_a: GO:0106044 ! guanine deglycation + +[Term] +id: GO:0106047 +name: polyamine deacetylation +namespace: biological_process +def: "The modification of acetylpolyamine by the removal of acetyl groups." [PMID:28516954] +is_a: GO:0006595 ! polyamine metabolic process +is_a: GO:0098732 ! macromolecule deacylation + +[Term] +id: GO:0106048 +name: spermidine deacetylation +namespace: biological_process +def: "The modification of acetylspermadine by the removal of acetyl groups." [PMID:28516954] +synonym: "N8-acetylspermidine deacetylation" EXACT [] +is_a: GO:0008216 ! spermidine metabolic process +is_a: GO:0106047 ! polyamine deacetylation + +[Term] +id: GO:0106049 +name: regulation of cellular response to osmotic stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cellular response to osmotic stress." [PMID:10398679] +is_a: GO:0047484 ! regulation of response to osmotic stress +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0071470 ! cellular response to osmotic stress + +[Term] +id: GO:0106050 +name: tRNA 2'-O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide." [PMID:17242307] +is_a: GO:0008175 ! tRNA methyltransferase activity +is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity + +[Term] +id: GO:0106054 +name: tRNA U34 sulfurtransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+." [PMID:12549933, PMID:16387657] +synonym: "tRNA U34 2-thiouridylase" EXACT [] +synonym: "tRNA U34 thiol-transferase activity" EXACT [] +synonym: "tRNA-specific 2-thiouridylase" RELATED [] +is_a: GO:0016783 ! sulfurtransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0106055 +name: mannosyl-oligosaccharide 1,2-alpha-mannosidase complex +namespace: cellular_component +def: "A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bhm, PMID:21700223] +comment: An example is MNL1 (P38888) in Saccharomyces cerevisiae. PMID:19124653 (by physical interaction evidence). +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005788 ! endoplasmic reticulum lumen + +[Term] +id: GO:0106056 +name: regulation of calcineurin-mediated signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] +is_a: GO:0050848 ! regulation of calcium-mediated signaling +relationship: regulates GO:0097720 ! calcineurin-mediated signaling + +[Term] +id: GO:0106057 +name: negative regulation of calcineurin-mediated signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signalling." [PMID:25081204] +is_a: GO:0050849 ! negative regulation of calcium-mediated signaling +is_a: GO:0106056 ! regulation of calcineurin-mediated signaling +relationship: negatively_regulates GO:0097720 ! calcineurin-mediated signaling + +[Term] +id: GO:0106058 +name: positive regulation of calcineurin-mediated signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcineurin-mediated signaling." [PMID:25081204] +is_a: GO:0050850 ! positive regulation of calcium-mediated signaling +is_a: GO:0106056 ! regulation of calcineurin-mediated signaling +relationship: positively_regulates GO:0097720 ! calcineurin-mediated signaling + +[Term] +id: GO:0106059 +name: tRNA (cytidine 56-2'-O)-methyltransferase +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA." [EC:2.1.1.206] +is_a: GO:0052666 ! tRNA (cytosine-2'-O-)-methyltransferase activity + +[Term] +id: GO:0106060 +name: regulation of exit from meiosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exit from mitosis." [GOC:al, PMID:11493649] +is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition +relationship: regulates GO:1990947 ! exit from meiosis + +[Term] +id: GO:0106061 +name: negative regulation of exit from meiosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649] +is_a: GO:0106060 ! regulation of exit from meiosis +is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition +relationship: negatively_regulates GO:1990947 ! exit from meiosis + +[Term] +id: GO:0106062 +name: positive regulation of exit from meiosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exit from meiosis." [GOC:al, PMID:11493649] +is_a: GO:0106060 ! regulation of exit from meiosis +is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition +relationship: positively_regulates GO:1990947 ! exit from meiosis + +[Term] +id: GO:0106063 +name: G protein-coupled folate receptor activity +namespace: molecular_function +def: "Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity." [PMID:26906738] +synonym: "G-protein coupled folate receptor activity" EXACT [] +synonym: "G-protein coupled folic acid receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:0106064 +name: regulation of cobalamin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [PMID:29056341] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: regulates GO:0009235 ! cobalamin metabolic process + +[Term] +id: GO:0106068 +name: SUMO ligase complex +namespace: cellular_component +def: "A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex." [PMID:16847351] +synonym: "SUMO transferase complex" EXACT [] +synonym: "SUMO-protein ligase complex" EXACT [] +synonym: "Sumoylation complex" EXACT [] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0106069 +name: synapsis initiation complex +namespace: cellular_component +def: "A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase." [PMID:16847351] +is_a: GO:0106068 ! SUMO ligase complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0000794 ! condensed nuclear chromosome + +[Term] +id: GO:0106070 +name: regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489] +synonym: "regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0106071 +name: positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489] +synonym: "positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +relationship: positively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0106072 +name: negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway." [GOC:hjd, PMID:19246489] +synonym: "negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +relationship: negatively_regulates GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0106073 +name: dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol." [GOC:ha, PMID:9597543] +xref: EC:2.4.1.256 +xref: RHEA:29543 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0106074 +name: aminoacyl-tRNA metabolism involved in translational fidelity +namespace: biological_process +def: "Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation." [GOC:hjd] +synonym: "aminoacyl-tRNA correction" RELATED [] +synonym: "aminoacyl-tRNA editin" RELATED [] +synonym: "aminoacyl-tRNA proofreading" RELATED [] +is_a: GO:0006399 ! tRNA metabolic process +is_a: GO:0006450 ! regulation of translational fidelity + +[Term] +id: GO:0106075 +name: peptide N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide." [PMID:29211711] +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0106076 +name: peptide-lysine-N-succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide." [PMID:29211711] +is_a: GO:0106075 ! peptide N-succinyltransferase activity + +[Term] +id: GO:0106077 +name: histone succinylation +namespace: biological_process +def: "The modification of a histone by the addition of an succinyl group." [PMID:29211711] +is_a: GO:0018335 ! protein succinylation + +[Term] +id: GO:0106078 +name: histone succinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone." [PMID:29211711] +is_a: GO:0106075 ! peptide N-succinyltransferase activity + +[Term] +id: GO:0106080 +name: GATOR1 complex binding +namespace: molecular_function +def: "Binding to a GATOR1 complex." [PMID:28199306] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0106081 +name: maltose import across plasma membrane +namespace: biological_process +def: "The directed movement of maltose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464] +is_a: GO:0098704 ! carbohydrate import across plasma membrane +is_a: GO:1904981 ! maltose transmembrane transport + +[Term] +id: GO:0106082 +name: sucrose import across plasma membrane +namespace: biological_process +def: "The directed movement of sucrose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:11136464] +is_a: GO:0098704 ! carbohydrate import across plasma membrane +is_a: GO:1904982 ! sucrose transmembrane transport + +[Term] +id: GO:0106083 +name: nuclear membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of the nuclear membrane." [GOC:lnp, PMID:28356353] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005635 ! nuclear envelope +relationship: part_of GO:0031224 ! intrinsic component of membrane + +[Term] +id: GO:0106084 +name: mitotic nuclear membrane microtubule tethering complex +namespace: cellular_component +def: "A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane." [GOC:lnp, PMID:28356353] +comment: In S. cerevisae Mps2-Bpb1 is the membrane anchor sub complex and Spc29 is the spindle pole body linker molecule. +synonym: "Mps2-Bbp1-Spc29 complex" RELATED [] +synonym: "nuclear membrane mitotic spindle pole body tethering complex" EXACT [] +is_a: GO:0106094 ! nuclear membrane microtubule tethering complex + +[Term] +id: GO:0106088 +name: regulation of cell adhesion involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] +is_a: GO:0030155 ! regulation of cell adhesion +relationship: regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis + +[Term] +id: GO:0106089 +name: negative regulation of cell adhesion involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] +is_a: GO:0007162 ! negative regulation of cell adhesion +is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis +is_a: GO:1903671 ! negative regulation of sprouting angiogenesis +relationship: negatively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis + +[Term] +id: GO:0106090 +name: positive regulation of cell adhesion involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24177325] +is_a: GO:0045785 ! positive regulation of cell adhesion +is_a: GO:0106088 ! regulation of cell adhesion involved in sprouting angiogenesis +relationship: positively_regulates GO:0120078 ! cell adhesion involved in sprouting angiogenesis + +[Term] +id: GO:0106091 +name: glial cell projection elongation +namespace: biological_process +def: "The process of creating an elongation or projection from a glial cell." [GOC:ha, PMID:27131624] +is_a: GO:0048858 ! cell projection morphogenesis +relationship: part_of GO:0021782 ! glial cell development + +[Term] +id: GO:0106092 +name: glial cell projection elongation involved in axon ensheathment +namespace: biological_process +def: "The extension of a glial cell process or projection to wrap around an axon." [GOC:ha, PMID:27131624] +is_a: GO:0008366 ! axon ensheathment +is_a: GO:0106091 ! glial cell projection elongation + +[Term] +id: GO:0106093 +name: EDS1 disease-resistance complex +namespace: cellular_component +def: "A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes." [GOC:bhm, PMID:11574472, PMID:16040633] +comment: Interacts with the R genes triggering ETI and systemic resistance. +synonym: "EDS1-PAD4 complex" NARROW [] +synonym: "EDS1-PAD4-SAG101 complex" NARROW [] +synonym: "EDS1-SAG101 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0106094 +name: nuclear membrane microtubule tethering complex +namespace: cellular_component +def: "A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules." [GOC:vw, PMID:19225124] +is_a: GO:0106083 ! nuclear membrane protein complex + +[Term] +id: GO:0106095 +name: m7G(5')pppN diphosphatase complex +namespace: cellular_component +def: "A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide." [GOC:lnp, PMID:22985415, PMID:26258763] +synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme" EXACT [] +synonym: "DCS1 decapping scavenger complex" EXACT [] +synonym: "M(7)G(5')pppN pyrophosphatase enzyme" EXACT [] +synonym: "m7G(5')pppN diphosphatase enzyme" EXACT [] +synonym: "m7G(5')pppN pyrophosphatase enzyme" EXACT [] +is_a: GO:0034518 ! RNA cap binding complex +is_a: GO:1903293 ! phosphatase complex + +[Term] +id: GO:0106096 +name: response to ceramide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:0106097 +name: cellular response to ceramide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus." [PMID:18006463] +is_a: GO:0071396 ! cellular response to lipid + +[Term] +id: GO:0106098 +name: NAGS/NAGK complex +namespace: cellular_component +def: "A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate." [GOC:lnp, PMID:11553611] +is_a: GO:0031248 ! protein acetyltransferase complex +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups +is_a: GO:0098798 ! mitochondrial protein-containing complex +relationship: part_of GO:0005759 ! mitochondrial matrix + +[Term] +id: GO:0106099 +name: 2-keto-3-deoxy-L-rhamnonate aldolase activity +namespace: molecular_function +def: "Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde." [EC:4.1.2.53, GOC:imk, PMID:18754683] +xref: EC:4.1.2.53 +xref: RHEA:25784 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0106100 +name: beta-pinacene synthase activity +namespace: molecular_function +def: "Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene." [GOC:rjd, PMID:28696553] +is_a: GO:0010333 ! terpene synthase activity + +[Term] +id: GO:0106101 +name: ER-dependent peroxisome localization +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum." [GOC:pga, PMID:19479899, PMID:26408931] +is_a: GO:0072662 ! protein localization to peroxisome + +[Term] +id: GO:0106103 +name: COPII vesicles tethering complex +namespace: cellular_component +def: "A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae." [GOC:lnp, PMID:21482742, PMID:9628863] +synonym: "Bug1-Grh1 complex" NARROW [] +synonym: "GRASP65-GM130 complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0099023 ! vesicle tethering complex +relationship: part_of GO:0033106 ! cis-Golgi network membrane + +[Term] +id: GO:0106104 +name: regulation of glutamate receptor clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamate receptor clustering." [GOC:ha, PMID:28455372] +is_a: GO:1903909 ! regulation of receptor clustering +relationship: regulates GO:0097688 ! glutamate receptor clustering + +[Term] +id: GO:0106105 +name: Ala-tRNA(Thr) hydrolase activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of misacylated ala-tRNA(thr)." [PMID:29410408] +synonym: "L-alanyl-tRNA(Thr) deacylase" EXACT [] +is_a: GO:0002161 ! aminoacyl-tRNA editing activity + +[Term] +id: GO:0106106 +name: cold-induced thermogenesis +namespace: biological_process +def: "The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature." [PMID:27876809] +synonym: "CIT" RELATED [] +is_a: GO:0001659 ! temperature homeostasis +is_a: GO:1990845 ! adaptive thermogenesis + +[Term] +id: GO:0106107 +name: regulation of (R)-mevalonic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process + +[Term] +id: GO:0106108 +name: negative regulation of (R)-mevalonic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process +relationship: negatively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process + +[Term] +id: GO:0106109 +name: positive regulation of (R)-mevalonic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of (R)-mevalonic acid biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:24296663] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:0106107 ! regulation of (R)-mevalonic acid biosynthetic process +relationship: positively_regulates GO:1901737 ! (R)-mevalonic acid biosynthetic process + +[Term] +id: GO:0106110 +name: vomitoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, also known as deoxynivalenol, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." [http://www.inchem.org/documents/jecfa/jecmono/v47je05.htm, https://doi.org/10.1007/BF03356188, PMID:19333439, PMID:25680507, PMID:25758923, PMID:8637056] +synonym: "deoxynivalenol biosynthetic process" EXACT [] +synonym: "DON biosynthetic process" EXACT [] +synonym: "vomitoxin anabolism" EXACT [] +synonym: "vomitoxin biosynthesis" EXACT [] +synonym: "vomitoxin formation" EXACT [] +synonym: "vomitoxin synthesis" EXACT [] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0097176 ! epoxide metabolic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0106111 +name: regulation of mitotic cohesin ssDNA (lagging strand) loading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] +is_a: GO:1905405 ! regulation of mitotic cohesin loading +relationship: regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading + +[Term] +id: GO:0106112 +name: negative regulation of mitotic cohesin ssDNA (lagging strand) loading +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] +is_a: GO:0106111 ! regulation of mitotic cohesin ssDNA (lagging strand) loading +is_a: GO:1905412 ! negative regulation of mitotic cohesin loading +relationship: negatively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading + +[Term] +id: GO:0106113 +name: positive regulation of mitotic cohesin ssDNA (lagging strand) loading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading." [PMID:29358048] +is_a: GO:0106111 ! regulation of mitotic cohesin ssDNA (lagging strand) loading +is_a: GO:1905406 ! positive regulation of mitotic cohesin loading +relationship: positively_regulates GO:0062022 ! mitotic cohesin ssDNA (lagging strand) loading + +[Term] +id: GO:0106114 +name: regulation of mitotic cohesin dsDNA (leading strand) loading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] +is_a: GO:1905405 ! regulation of mitotic cohesin loading +relationship: regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading + +[Term] +id: GO:0106115 +name: negative regulation of mitotic cohesin dsDNA (leading strand) loading +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] +is_a: GO:0106114 ! regulation of mitotic cohesin dsDNA (leading strand) loading +is_a: GO:1905412 ! negative regulation of mitotic cohesin loading +relationship: negatively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading + +[Term] +id: GO:0106116 +name: positive regulation of mitotic cohesin dsDNA (leading strand) loading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin dsDNA (leading strand) loading." [PMID:29358048] +is_a: GO:0106114 ! regulation of mitotic cohesin dsDNA (leading strand) loading +is_a: GO:1905406 ! positive regulation of mitotic cohesin loading +relationship: positively_regulates GO:0062021 ! mitotic cohesin dsDNA (leading strand) loading + +[Term] +id: GO:0106117 +name: acidocalcisome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GO:0020022, PMID:25964650, PMID:26523947] +synonym: "acidocalcisome biogenesis" EXACT [] +synonym: "acidocalcisome organisation" EXACT [] +synonym: "acidocalcisome organization and biogenesis" EXACT [] +synonym: "metachromatic granule organization" EXACT [] +synonym: "polyphosphate vacuole organization" RELATED [] +synonym: "volutin granule organization" EXACT [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0106118 +name: regulation of sterol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0016126 ! sterol biosynthetic process + +[Term] +id: GO:0106119 +name: negative regulation of sterol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0106118 ! regulation of sterol biosynthetic process +relationship: negatively_regulates GO:0016126 ! sterol biosynthetic process + +[Term] +id: GO:0106120 +name: positive regulation of sterol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a sterol biosynthetic process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:16459310] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0106118 ! regulation of sterol biosynthetic process +relationship: positively_regulates GO:0016126 ! sterol biosynthetic process + +[Term] +id: GO:0106121 +name: positive regulation of cobalamin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] +is_a: GO:0046136 ! positive regulation of vitamin metabolic process +is_a: GO:0106064 ! regulation of cobalamin metabolic process +is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process +relationship: positively_regulates GO:0009235 ! cobalamin metabolic process + +[Term] +id: GO:0106122 +name: negative regulation of cobalamin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process." [PMID:29056341] +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:0106064 ! regulation of cobalamin metabolic process +is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process +relationship: negatively_regulates GO:0009235 ! cobalamin metabolic process + +[Term] +id: GO:0106123 +name: reservosome +namespace: cellular_component +def: "A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes." [GOC:ach, PMID:12204365, PMID:15521631, PMID:1845219, PMID:19288526, PMID:21818313, PMID:22425988] +is_a: GO:0000322 ! storage vacuole +is_a: GO:0000323 ! lytic vacuole + +[Term] +id: GO:0106124 +name: reservosome lumen +namespace: cellular_component +def: "The volume enclosed by the membranes of a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0106123 ! reservosome + +[Term] +id: GO:0106125 +name: reservosome matrix +namespace: cellular_component +def: "A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0106123 ! reservosome + +[Term] +id: GO:0106126 +name: reservosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a reservosome." [GOC:ach, PMID:12204365, PMID:15521631, PMID:18452191, PMID:19288526, PMID:21818313, PMID:22425988] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0106123 ! reservosome + +[Term] +id: GO:0106128 +name: negative regulation of store-operated calcium entry +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642] +is_a: GO:0051926 ! negative regulation of calcium ion transport +is_a: GO:2001256 ! regulation of store-operated calcium entry +relationship: negatively_regulates GO:0002115 ! store-operated calcium entry + +[Term] +id: GO:0106129 +name: positive regulation of store-operated calcium entry +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium entry." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23447642] +is_a: GO:0051928 ! positive regulation of calcium ion transport +is_a: GO:2001256 ! regulation of store-operated calcium entry +relationship: positively_regulates GO:0002115 ! store-operated calcium entry + +[Term] +id: GO:0106130 +name: purine phosphoribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate." [PMID:5123876] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0106134 +name: positive regulation of cardiac muscle cell contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] +is_a: GO:0086004 ! regulation of cardiac muscle cell contraction +is_a: GO:1903116 ! positive regulation of actin filament-based movement +relationship: positively_regulates GO:0086003 ! cardiac muscle cell contraction + +[Term] +id: GO:0106135 +name: negative regulation of cardiac muscle cell contraction +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction." [PMID:19525381] +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0055118 ! negative regulation of cardiac muscle contraction +is_a: GO:0086004 ! regulation of cardiac muscle cell contraction +relationship: negatively_regulates GO:0086003 ! cardiac muscle cell contraction + +[Term] +id: GO:0106136 +name: lectin-induced modified bacterial internalization +namespace: biological_process +def: "The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:rjd, PMID:30049880] +synonym: "LIMBI" EXACT [] +is_a: GO:0051702 ! biological process involved in interaction with symbiont + +[Term] +id: GO:0106137 +name: IkappaB kinase complex binding +namespace: molecular_function +def: "Binding to a IkappaB kinase complex." [GOC:pga, PMID:12492477] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0106138 +name: Sec61 translocon complex binding +namespace: molecular_function +def: "Binding to a Sec61 translocon complex." [GOC:pga, PMID:9792704] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0106139 +name: symbiont cell surface +namespace: cellular_component +def: "The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:rjd, PMID:30049880] +synonym: "endosymbiont cell surface" EXACT [] +is_a: GO:0044217 ! other organism part + +[Term] +id: GO:0106140 +name: P-TEFb complex binding +namespace: molecular_function +def: "Binding to a P-TEFb complex." [GOC:pga, PMID:18391197] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0106141 +name: flavin prenyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate." [GOC:imk, PMID:26083743] +xref: EC:2.5.1.129 +xref: RHEA:37743 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0106142 +name: rRNA (adenine-N1-)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA." [EC:2.1.1.287, PMID:23180764] +comment: The m(1)A modification at position 645 in the large rRNA is highly conserved in eukaryotes. +synonym: "25S rRNA (adenine(645)-N(1))-methyltransferase" RELATED [EC:2.1.1.287] +synonym: "25S rRNA m(1)A(645) methyltransferase" RELATED [EC:2.1.1.287] +xref: EC:2.1.1.287 +xref: RHEA:43792 +is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity + +[Term] +id: GO:0106143 +name: tRNA (m7G46) methyltransferase complex +namespace: cellular_component +def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat)." [GOC:vw, PMID:15811913, PMID:1738232, PMID:18164779, PMID:18184583] +synonym: "Trm8-Trm82 complex" EXACT [] +synonym: "tRNA (m7G46) methyltransferase" EXACT [] +synonym: "tRNA m7G methylation complex" EXACT [] +is_a: GO:0043527 ! tRNA methyltransferase complex + +[Term] +id: GO:0106144 +name: fraxetin 5-hydroxylase activity +namespace: molecular_function +def: "Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20." [GOC:lr, PMID:29581584, RHEA:57844] +xref: EC:1.14.14.164 +xref: RHEA:57844 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106145 +name: scopoletin 8-hydroxylase activity +namespace: molecular_function +def: "Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2)." [GOC:lr, PMID:29361149, PMID:29581584, RHEA:57848] +xref: EC:1.14.11.60 +xref: RHEA:57848 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106146 +name: sideretin biosynthesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sideretin." [GOC:lr, PMID:29581584] +is_a: GO:0009805 ! coumarin biosynthetic process + +[Term] +id: GO:0106147 +name: fraxetin biosynthesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fraxetin." [GOC:lr, PMID:29581584] +is_a: GO:0009805 ! coumarin biosynthetic process + +[Term] +id: GO:0106148 +name: 4-hydroxyindole-3- carbonyl nitrile biosynthesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside." [GOC:lr, PMID:26352477] +is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process + +[Term] +id: GO:0106149 +name: indole-3-carbonyl nitrile 4-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP(+) + H20." [GOC:lr, PMID:26352477, RHEA:57864] +xref: EC:1.14.14.165 +xref: RHEA:57864 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106150 +name: zearalenone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals." [GOC:ach, PMID:16517624, PMID:20578001] +is_a: GO:0033068 ! macrolide biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process + +[Term] +id: GO:0106151 +name: CNBH domain intrinsic ligand binding +namespace: molecular_function +def: "Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide." [GOC:cvs, PMID:27025590, PMID:29567795] +comment: It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids. +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0106153 +name: phosphorylated histone binding +namespace: molecular_function +def: "Binding to a histone in which a residue has been modified by phosphorylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." [GOC:mah, PMID:20679485] +is_a: GO:0042393 ! histone binding +is_a: GO:0140031 ! phosphorylation-dependent protein binding + +[Term] +id: GO:0106154 +name: perithecium formation +namespace: biological_process +def: "The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, GOC:ach, PMID:19547974, PMID:21134480, PMID:25311923] +is_a: GO:0120165 ! perithecium development + +[Term] +id: GO:0106155 +name: peptidyl-lysine 3-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2." [GOC:al, PMID:29915238, RHEA:57152] +xref: EC:1.14.11.63 +xref: RHEA:57152 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0106156 +name: peptidyl-lysine 4-dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2." [GOC:pde, PMID:24486019, RHEA:57156] +xref: RHEA:57156 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0106157 +name: peptidyl-arginine 3-dioxygenase activity +namespace: molecular_function +alt_id: GO:0140554 +def: "Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate." [PMID:29563586] +synonym: "L-arginine 3-hydroxylase activity" EXACT [] +xref: RHEA:56744 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0106158 +name: glycero-3-phosphocholine acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine." [PMID:18430972, PMID:27758859, RHEA:58476] +synonym: "glycerophosphocholine O-acyltransferase activity" EXACT [] +synonym: "GPACT activity" EXACT [] +xref: RHEA:58476 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0106159 +name: obsolete regulation of small RNA loading onto RISC +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent small RNA loading onto RISC." [GOC:ha, PMID:29775584] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0106160 +name: obsolete negative regulation of small RNA loading onto RISC +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0106161 +name: obsolete positive regulation of small RNA loading onto RISC +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of small RNA loading onto RISC." [GOC:ha, PMID:29775584] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:0106162 +name: mRNA N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate." [GOC:sp, PMID:30449621] +xref: RHEA:58480 +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:0106163 +name: regulation of exonucleolytic catabolism of deadenylated mRNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114] +is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +relationship: regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA + +[Term] +id: GO:0106164 +name: positive regulation of exonucleolytic catabolism of deadenylated mRNA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114] +is_a: GO:0106163 ! regulation of exonucleolytic catabolism of deadenylated mRNA +is_a: GO:1900153 ! positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +relationship: positively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA + +[Term] +id: GO:0106165 +name: negative regulation of exonucleolytic catabolism of deadenylated mRNA +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay." [GOC:vw, PMID:30601114] +is_a: GO:0106163 ! regulation of exonucleolytic catabolism of deadenylated mRNA +is_a: GO:1900152 ! negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +relationship: negatively_regulates GO:0043928 ! exonucleolytic catabolism of deadenylated mRNA + +[Term] +id: GO:0106166 +name: spindle pole body-nuclear membrane anchor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body." [GOC:vw, PMID:9763447] +synonym: "nuclear membrane-spindle pole body anchor activity" EXACT [] +synonym: "spindle pole body nuclear membrane anchor activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity +is_a: GO:0140475 ! spindle pole body anchor activity + +[Term] +id: GO:0106167 +name: extracellular ATP signaling +namespace: biological_process +def: "A series of molecular signals mediated by the detection of extracellular ATP." [GOC:tb, PMID:12948585, PMID:20817461, PMID:29274390] +is_a: GO:0007165 ! signal transduction +is_a: GO:0071318 ! cellular response to ATP + +[Term] +id: GO:0106172 +name: COPI-coated vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a COPI-coated endocytic vesicle." [GOC:pde, PMID:29535154] +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0030137 ! COPI-coated vesicle + +[Term] +id: GO:0106173 +name: COPII-coated vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a COPII-coated endocytic vesicle." [GOC:pde, PMID:21172817] +is_a: GO:0060205 ! cytoplasmic vesicle lumen + +[Term] +id: GO:0106174 +name: phagolysosome vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a phagolysosome." [GOC:pde, PMID:29471269] +is_a: GO:0005775 ! vacuolar lumen +is_a: GO:0060205 ! cytoplasmic vesicle lumen +is_a: GO:0097013 ! phagocytic vesicle lumen +relationship: part_of GO:0032010 ! phagolysosome + +[Term] +id: GO:0106175 +name: phagolysosome vesicle membrane +namespace: cellular_component +def: "The lipid bylayer surrounding a phagolysosome." [GOC:pde, PMID:29471269] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +relationship: part_of GO:0032010 ! phagolysosome + +[Term] +id: GO:0106176 +name: clathrin-coated endocytic vesicle lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a clathrin-coated endocytic vesicle." [GOC:pde, PMID:2516741] +is_a: GO:0071682 ! endocytic vesicle lumen +relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle + +[Term] +id: GO:0106177 +name: cyclic-GMP-AMP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP." [GOC:sp, PMID:25344812, RHEA:58808] +xref: RHEA:58808 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0106178 +name: obsolete translocase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis the movement of ions or molecules across membranes or their separation within membranes." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.-.-.- +is_obsolete: true + +[Term] +id: GO:0106179 +name: obsolete translocase activity acting on inorganic cations and their chelates +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.2.-.- +is_obsolete: true + +[Term] +id: GO:0106180 +name: obsolete translocase activty of hydrons +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of hydrons (hydron being the general name for H+ in its natural abundance)." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.1.-.- +is_obsolete: true + +[Term] +id: GO:0106181 +name: obsolete translocase activity acting on inorganic anions +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic anions." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.3.-.- +is_obsolete: true + +[Term] +id: GO:0106182 +name: obsolete translocase activity acting on amino acids and peptides. +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.4.-.- +is_obsolete: true + +[Term] +id: GO:0106183 +name: obsolete translocase activity acting on carbohydrates and their derivatives. +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of carbohydrates and their derivatives." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.5.-.- +is_obsolete: true + +[Term] +id: GO:0106184 +name: obsolete translocation activity acting on other compounds +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of other compounds not included in EC:7.1 through EC:7.5 ." [GOC:hjd, http://www.enzyme-database.org/] +comment: This term was made obsolete because the name and scope ( other compounds not included in EC:7.1 through EC:7.5 ) is not good ontological practice. +xref: EC:7.6.-.- +is_obsolete: true + +[Term] +id: GO:0106185 +name: histone H3-K37 methylation +namespace: biological_process +def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone." [GOC:mah, PMID:30773398] +synonym: "histone H3 K37 methylation" EXACT [] +synonym: "histone H3K37me" EXACT [] +synonym: "histone lysine H3 K37 methylation" EXACT [] +is_a: GO:0034968 ! histone lysine methylation + +[Term] +id: GO:0106186 +name: cytoplasmic side of plasma membrane, cell tip +namespace: cellular_component +def: "The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:vw, PMID:28292899] +is_a: GO:0009898 ! cytoplasmic side of plasma membrane +relationship: part_of GO:0031520 ! plasma membrane of cell tip + +[Term] +id: GO:0106187 +name: obsolete translocase activity acting on hydrons linked to oxidoreductase reactions +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of hydrons linked to an oxidoreduction reaction." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.1.1.- +is_obsolete: true + +[Term] +id: GO:0106188 +name: obsolete translocase activity acting on hydrons linked the hydrolysis of a nucleoside triphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.1.2.- +is_obsolete: true + +[Term] +id: GO:0106189 +name: obsolete translocase activity acting on hydrons linked to the hydrolysis of a diphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of hydrons linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.1.3.- +is_obsolete: true + +[Term] +id: GO:0106190 +name: obsolete translocase activity acting on hydrons linked to a decarboxylation reaction +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of hydrons linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.1.4.- +is_obsolete: true + +[Term] +id: GO:0106191 +name: obsolete translocase activity acting on inogranic cations linked to oxidoreductase reactions +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic cations linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.2.1.- +is_obsolete: true + +[Term] +id: GO:0106192 +name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +is_obsolete: true + +[Term] +id: GO:0106193 +name: obsolete translocase activity acting on inorganic cations and their chelates linked to the hydrolysis of a diphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic cations and their chelates linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.2.3.- +is_obsolete: true + +[Term] +id: GO:0106194 +name: obsolete translocase activity acting on inorganic cations and their chelates linked to a decarboxylation reaction +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transocation of inorganic cations and their chelates linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.2.4.- +is_obsolete: true + +[Term] +id: GO:0106195 +name: obsolete translocase activty acting on inorganic anions linked to oxidoreductase reactions +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.3.1.- +is_obsolete: true + +[Term] +id: GO:0106196 +name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a nucleoside triphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic anions linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.3.2.- +is_obsolete: true + +[Term] +id: GO:0106197 +name: obsolete translocase activity acting on inorganic anions linked to the hydrolysis of a diphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of inorganic anions llinked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.3.3.- +is_obsolete: true + +[Term] +id: GO:0106198 +name: obsolete translocase activity acting on inorganic anions linked to a decarboxylation reaction +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of an inorganic anion linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.3.4.- +is_obsolete: true + +[Term] +id: GO:0106199 +name: obsolete translocase activity acting on amino acids and peptides linked to oxidoreductase reactions +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to oxidoreductase reactions." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.4.1.- +is_obsolete: true + +[Term] +id: GO:0106200 +name: obsolete translocase activity acting on amio acids and peptides linked to the hydrolysis of a nucleoside triphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a nucleoside triphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.4.2.- +is_obsolete: true + +[Term] +id: GO:0106201 +name: obsolete translocase activity acting on amino acids and peptides linked to the hydrolysis of a diphosphate +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of amino acids and peptides linked to the hydrolysis of a diphosphate." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.4.3.- +is_obsolete: true + +[Term] +id: GO:0106202 +name: obsolete translocase activity acting on amino acids and peptides linked to a decarboxylation reaction +namespace: molecular_function +def: "OBSOLETE. Catalysis of the translocation of amno acids and peptides linked to a decarboxylation reaction." [GOC:hjd, http://www.enzyme-database.org] +comment: This term was made obsolete because the concept of using the non-4 digit EC classes as parent terms for the transporter banch of the onotolgy was consided confusing. +xref: EC:7.4.4.- +is_obsolete: true + +[Term] +id: GO:0106210 +name: culmorin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris." [GOC:ach, PMID:19880637, PMID:26673640] +synonym: "culmorin anabolism" EXACT [] +synonym: "culmorin biosynthesis" EXACT [] +synonym: "culmorin formation" EXACT [] +synonym: "culmorin synthesis" EXACT [] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:0106211 +name: inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate." [GOC:rn, PMID:29540476] +synonym: "5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT [] +synonym: "5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity" EXACT [] +synonym: "5-PP-InsP4 activity" EXACT [] +xref: RHEA:59500 +is_a: GO:0052840 ! inositol diphosphate tetrakisphosphate diphosphatase activity + +[Term] +id: GO:0106212 +name: centromere detachment from spindle pole body involved in meiotic chromosome organization +namespace: biological_process +def: "The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693] +synonym: "centromere detachment from SPB involved in meiotic chromosome organization" EXACT [] +synonym: "centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT [] +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle + +[Term] +id: GO:0106213 +name: kinetochore disassembly involved in meiotic chromosome organization +namespace: biological_process +def: "The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I." [GOC:mah, PMID:27611693] +synonym: "kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle" EXACT [] +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle + +[Term] +id: GO:0106214 +name: regulation of vesicle fusion with Golgi apparatus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] +is_a: GO:0031338 ! regulation of vesicle fusion +is_a: GO:1903358 ! regulation of Golgi organization +relationship: regulates GO:0048280 ! vesicle fusion with Golgi apparatus + +[Term] +id: GO:0106215 +name: negative regulation of vesicle fusion with Golgi apparatus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus." [GOC:se, PMID:26195667] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus +relationship: negatively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus + +[Term] +id: GO:0106216 +name: positive regulation of vesicle fusion with Golgi apparatus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus." [GOC:se, PMID:26195667] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:0106214 ! regulation of vesicle fusion with Golgi apparatus +relationship: positively_regulates GO:0048280 ! vesicle fusion with Golgi apparatus + +[Term] +id: GO:0106217 +name: tRNA C3-cytosine methylation +namespace: biological_process +def: "The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine." [PMID:28655767] +is_a: GO:0030488 ! tRNA methylation + +[Term] +id: GO:0106218 +name: galactosaminogalactan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN)." [PMID:173713, PMID:22102815, PMID:24257745, PMID:26492565, PMID:26932183, PMID:27048799, PMID:30667338] +synonym: "GAG biosynthetic process" RELATED [] +synonym: "galactosaminogalactan anabolism" RELATED [] +synonym: "galactosaminogalactan biosynthesis" RELATED [] +synonym: "galactosaminogalactan formation" RELATED [] +synonym: "galactosaminogalactan synthesis" RELATED [] +is_a: GO:0051278 ! fungal-type cell wall polysaccharide biosynthetic process + +[Term] +id: GO:0106219 +name: zinc ion sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc." [GOC:vw, PMID:31239353] +is_a: GO:0008270 ! zinc ion binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0106220 +name: pyocyanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrocyanin, an iminium betaine that is 5-methylphenazin-5-ium which is substituted at position 1 by an oxidanidyl group." [PMID:28715477] +synonym: "pyocyanin biosynthetic process" EXACT [] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0106222 +name: lncRNA binding +namespace: molecular_function +def: "Binding to a long noncoding RNA (lncRNA)." [PMID:25578728] +synonym: "long noncoding RNA binding" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0106223 +name: germacrene A hydroxylase activity +namespace: molecular_function +alt_id: GO:0102260 +def: "Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]." [PMID:11299372, PMID:20351109, RHEA:30303] +comment: Formerly EC:1.1.1.314. +synonym: "germacrene A alcohol dehydrogenase activity" RELATED [] +xref: EC:1.14.14.95 +xref: MetaCyc:RXN-12449 +xref: RHEA:30303 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106225 +name: peptidyl-lysine 2-hydroxyisobutyrylation +namespace: biological_process +def: "The 2-hydroxyisobutyrylation of a lysine residue in a protein." [GOC:sp, PMID:29775581] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0106226 +name: peptide 2-hydroxyisobutyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide." [GOC:sp, PMID:29775581] +xref: RHEA:24180 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0106227 +name: peptidyl-lysine glutarylation +namespace: biological_process +def: "The glutarylation of a lysine residue in a protein." [GOC:sp, PMID:31542297] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0106228 +name: peptide glutaryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]." [GOC:sp, PMID:31542297] +xref: RHEA:18009 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0106229 +name: histone glutaryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone." [GOC:sp, PMID:31542297] +is_a: GO:0106228 ! peptide glutaryltransferase activity + +[Term] +id: GO:0106230 +name: protein depropionylation +namespace: biological_process +def: "The removal of a propionyl group from a residue in a peptide or protein." [GOC:sp, PMID:30026585] +is_a: GO:0035601 ! protein deacylation + +[Term] +id: GO:0106231 +name: protein-propionyllysine depropionylase activity +namespace: molecular_function +def: "Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [GOC:sp, PMID:30026585, RHEA:23500] +comment: This reaction is the removal of a propionyl group from a propionylated lysine residue of a protein or peptide. +xref: RHEA:23500 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0106232 +name: hydroxyisourate hydrolase complex +namespace: cellular_component +def: "A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin." [GOC:bhm, PMID:21795808] +synonym: "5-hydroxyisourate hydrolase complex" NARROW [] +synonym: "HIU hydrolase complex" NARROW [] +synonym: "HIUH complex" NARROW [] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0106233 +name: glycosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:ach, PMID:15539076, PMID:28426655, PMID:31341002, PMID:8056787] +synonym: "glycosome biogenesis" RELATED [] +synonym: "glycosome organisation" EXACT [] +synonym: "glycosome organization and biogenesis" RELATED [] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:0106234 +name: outer membrane protein complex +namespace: cellular_component +def: "Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC." [GOC:am, PMID:25267629, PMID:27282389] +is_a: GO:0098796 ! membrane protein complex + +[Term] +id: GO:0106235 +name: ceramide-1-phosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate." [GOC:lb, PMID:10359651] +xref: RHEA:50888 +is_a: GO:0042577 ! lipid phosphatase activity + +[Term] +id: GO:0106236 +name: rhamnolipid biosynthesis +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal." [GOC:vw, PMID:28715477] +synonym: "rhamnolipid production" RELATED [] +is_a: GO:0009247 ! glycolipid biosynthetic process + +[Term] +id: GO:0106237 +name: arachidonate 12(R)-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: arachidonate + O(2)=(5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [GOC:gap, PMID:10100631, PMID:11256953, RHEA:41336] +xref: RHEA:41336 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:0106238 +name: peregrinol diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O." [GOC:emb, PMID:24990389, PMID:29315936, RHEA:54652] +xref: EC:4.2.1.174 +xref: RHEA:54652 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0106239 +name: 9,13-epoxylabda-14-ene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate." [GOC:emb, PMID:24990389, RHEA:54512] +xref: EC:4.2.3.189 +xref: RHEA:54512 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0106240 +name: labd-13Z-ene-9,15,16-triol synthase activity +namespace: molecular_function +def: "Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29315936, RHEA:62192] +xref: RHEA:62192 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0106242 +name: kolavenyl diphosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate." [GOC:eab, PMID:29315936, RHEA:54676] +xref: EC:5.5.1.29 +xref: RHEA:54676 +is_a: GO:0016872 ! intramolecular lyase activity + +[Term] +id: GO:0106243 +name: syn-isopimara-7,15-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene." [GOC:emb, PMID:29315936, RHEA:62188] +xref: RHEA:62188 +is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates + +[Term] +id: GO:0106244 +name: eupatolide synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:eab, PMID:29758164, RHEA:57972] +xref: EC:1.14.14.169 +xref: RHEA:57972 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0106245 +name: L-serine-phosphatidylethanolamine phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine." [PMID:19014349, PMID:31869331, RHEA:27606] +xref: EC:2.7.8.29 +xref: RHEA:27606 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0106246 +name: regulation of poly(A)-specific ribonuclease activity +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [GOC:mah, PMID:29932902] +is_a: GO:1901917 ! regulation of exoribonuclease activity + +[Term] +id: GO:0106247 +name: negative regulation of poly(A)-specific ribonuclease activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of poly(A)-specific ribonuclease activity." [GOC:mah, PMID:29932902] +is_a: GO:0106246 ! regulation of poly(A)-specific ribonuclease activity +is_a: GO:1901918 ! negative regulation of exoribonuclease activity + +[Term] +id: GO:0106248 +name: positive regulation of poly(A)-specific ribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of poly(A)-specific ribonuclease activity." [GOC:mah, PMID:29932902] +is_a: GO:0106246 ! regulation of poly(A)-specific ribonuclease activity +is_a: GO:1901919 ! positive regulation of exoribonuclease activity + +[Term] +id: GO:0106249 +name: Nicalin-NOMO complex +namespace: cellular_component +def: "A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147." [GOC:al, GOC:bhm, PMID:20538592] +synonym: "Nicalin-TMEM147-NOMO complex" EXACT [PMID:32820719] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0106250 +name: DNA-binding transcription repressor activity, RNA polymerase III-specific +namespace: molecular_function +def: "A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III." [GOC:txnOH-2018, PMID:15590667, PMID:31833215] +comment: For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. +is_a: GO:0001217 ! DNA-binding transcription repressor activity + +[Term] +id: GO:0106251 +name: N4-acetylcytidine amidohydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate." [GOC:imk, PMID:31964920, RHEA:62932] +xref: RHEA:62932 +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0106253 +name: positive regulation of DNA strand resection involved in replication fork processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:vw, PMID:31575705] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0110026 ! regulation of DNA strand resection involved in replication fork processing +relationship: positively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing + +[Term] +id: GO:0106254 +name: lipid sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid." [GOC:vw, PMID:30075144] +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0106255 +name: hydroperoxy icosatetraenoate isomerase activity +namespace: molecular_function +def: "A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate." [PMID:12881489, RHEA:55560] +xref: EC:5.4.4.7 +xref: RHEA:55560 +is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups + +[Term] +id: GO:0106256 +name: hydroperoxy icosatetraenoate dehydratase activity +namespace: molecular_function +def: "A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O." [PMID:12881489, RHEA:55556] +xref: EC:4.2.1.152 +xref: RHEA:55556 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0106257 +name: glycerol-3-phosphate dehydrogenase [NADP+] activity +namespace: molecular_function +def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = glycerone phosphate + NADH + H+." [RHEA:11096] +xref: RHEA:11096 +is_a: GO:0047952 ! glycerol-3-phosphate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0106258 +name: L-serine-phosphatidylcholine phosphatidyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline." [PMID:19014349., RHEA:45088] +xref: RHEA:45088 +is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups + +[Term] +id: GO:0106259 +name: cell-to-cell migration in host +namespace: biological_process +def: "The directional movement of a symbiont from one host cell to another." [GOC:vw, PMID:29567712] +is_a: GO:0044001 ! migration in host + +[Term] +id: GO:0106260 +name: DNA-DNA tethering activity +namespace: molecular_function +alt_id: GO:0140564 +def: "Bridging together two regions of a DNA molecule." [PMID:29358048, PMID:30626735] +synonym: "double-stranded DNA bridging" EXACT [] +synonym: "dsDNA bridging" EXACT [] +is_a: GO:0003690 ! double-stranded DNA binding +is_a: GO:0060090 ! molecular adaptor activity + +[Term] +id: GO:0106261 +name: tRNA uridine(34) acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine." [PMID:25151136, PMID:30733442, RHEA:61020] +xref: RHEA:61020 +is_a: GO:0016407 ! acetyltransferase activity + +[Term] +id: GO:0106262 +name: 1-acylglycerophosphoethanolamine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA." [PMID:18287005, RHEA:32995] +xref: RHEA:32995 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0106263 +name: 1-acylglycerophosphoserine O-acyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA." [PMID:18287005, RHEA:33191] +xref: RHEA:33191 +is_a: GO:0008374 ! O-acyltransferase activity + +[Term] +id: GO:0106264 +name: protein serine kinase activity (using GTP as donor) +namespace: molecular_function +def: "Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]." [GOC:sp, PMID:32322062, RHEA:64020] +xref: RHEA:64020 +is_a: GO:0106310 ! protein serine kinase activity + +[Term] +id: GO:0106265 +name: THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA." [PMID:9446571, RHEA:64352] +synonym: "polyketide syntase" BROAD [] +xref: RHEA:64352 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0106266 +name: 3-chloro THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O." [PMID:20231486, RHEA:64356] +xref: RHEA:64356 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106267 +name: 3,5 dichloro-THPH synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O." [PMID:20231486, RHEA:64360] +xref: RHEA:64360 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106268 +name: 3,5-dichloro-THPH methyl transferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine." [PMID:20231486, RHEA:48396] +synonym: "DIF-1 syntase" RELATED [] +xref: RHEA:48396 +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0106271 +name: D-arabinose 1-dehydrogenase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH." [RHEA:21892] +xref: EC:1.1.1.117 +xref: RHEA:21892 +is_a: GO:0045290 ! D-arabinose 1-dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0106272 +name: protein localization to ERGIC +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] +is_a: GO:0034067 ! protein localization to Golgi apparatus + +[Term] +id: GO:0106273 +name: cytosol to ERGIC protein transport +namespace: biological_process +def: "The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC)." [PMID:32272059] +is_a: GO:0015031 ! protein transport + +[Term] +id: GO:0106274 +name: NAD+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:19149] +xref: EC:2.4.2.31 +xref: RHEA:19149 +is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity + +[Term] +id: GO:0106275 +name: NADP+-protein-arginine ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [RHEA:54884] +xref: EC:2.4.2.31 +xref: RHEA:54884 +is_a: GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity + +[Term] +id: GO:0106276 +name: biliberdin reductase NAD+ activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+." [RHEA:15797] +xref: EC:1.3.1.24 +xref: RHEA:15797 +is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity + +[Term] +id: GO:0106277 +name: biliverdin reductase (NADP+) activity +namespace: molecular_function +def: "Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+." [RHEA:15793] +xref: EC:1.3.1.24 +xref: RHEA:15793 +is_a: GO:0004074 ! biliverdin reductase (NAD(P)+) activity + +[Term] +id: GO:0106278 +name: regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the UDP-N_acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process + +[Term] +id: GO:0106279 +name: negative regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "negative regulation of UDP-GlcNAc biosynthesis" RELATED [] +synonym: "negative regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "negative regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process +relationship: negatively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process + +[Term] +id: GO:0106280 +name: positive regulation of UDP-N-acetylglucosamine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the UDP-N-acetylglucosamine biosynthetic process." [PMID:32579556] +synonym: "positive egulation of UDP-N-acetylglucosamine formation" RELATED [] +synonym: "positive regulation of UDP-GlcNAc biosynthetic process" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine anabolism" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine biosynthesis" RELATED [] +synonym: "positive regulation of UDP-N-acetylglucosamine synthesis" RELATED [] +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:0106278 ! regulation of UDP-N-acetylglucosamine biosynthetic process +relationship: positively_regulates GO:0006048 ! UDP-N-acetylglucosamine biosynthetic process + +[Term] +id: GO:0106281 +name: chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH." [PMID:12917011, RHEA:42036] +xref: RHEA:42036 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0106282 +name: isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH." [PMID:12917011, RHEA:42024] +xref: RHEA:42024 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0106283 +name: ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH." [PMID:12917011, RHEA:42028] +xref: RHEA:42028 +is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0106286 +name: (E)-caffeate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate." [PMID:22649270, RHEA:36299] +xref: RHEA:36299 +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0106288 +name: regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA." [PMID:32354837] +is_a: GO:0061013 ! regulation of mRNA catabolic process +relationship: regulates GO:0000290 ! deadenylation-dependent decapping of nuclear-transcribed mRNA + +[Term] +id: GO:0106289 +name: negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of deadenylation-dependent decapping of nuclear-transcribed mRNA." [PMID:32354837] +is_a: GO:0106288 ! regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA +is_a: GO:1902373 ! negative regulation of mRNA catabolic process +relationship: negatively_regulates GO:0000290 ! deadenylation-dependent decapping of nuclear-transcribed mRNA + +[Term] +id: GO:0106290 +name: trans-cinnamate-CoA ligase activity +namespace: molecular_function +def: "Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate." [PMID:22649270, RHEA:64788] +xref: RHEA:64788 +is_a: GO:0016405 ! CoA-ligase activity + +[Term] +id: GO:0106291 +name: superoxide-generating NADH oxidase activity. +namespace: molecular_function +def: "Catalysis of the reaction: NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide." [RHEA:63184] +xref: RHEA:63184 +is_a: GO:0016175 ! superoxide-generating NAD(P)H oxidase activity + +[Term] +id: GO:0106292 +name: superoxide-generating NADPH oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide." [RHEA:63180] +xref: RHEA:63180 +is_a: GO:0016175 ! superoxide-generating NAD(P)H oxidase activity + +[Term] +id: GO:0106293 +name: NADH oxidase H202-forming activity +namespace: molecular_function +def: "Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2)." [RHEA:11264] +xref: RHEA:11264 +is_a: GO:0016174 ! NAD(P)H oxidase H2O2-forming activity + +[Term] +id: GO:0106294 +name: NADPH oxidase H202-forming activity +namespace: molecular_function +def: "Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2)." [RHEA:11260] +xref: RHEA:11260 +is_a: GO:0016174 ! NAD(P)H oxidase H2O2-forming activity + +[Term] +id: GO:0106295 +name: resolvin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid." [PMID:24899309] +comment: Resolvin biosynthesis is a combination of oxidation, reduction and hydrolysis reactions involving lipoxygenases and cyclooxygenases. +is_a: GO:0006633 ! fatty acid biosynthetic process + +[Term] +id: GO:0106296 +name: D-series resolvin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid." [PMID:12391014] +is_a: GO:0106295 ! resolvin biosynthetic process + +[Term] +id: GO:0106297 +name: E-series resolvin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid." [PMID:21206090] +is_a: GO:0106295 ! resolvin biosynthetic process + +[Term] +id: GO:0106298 +name: 13-series resolvin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid." [PMID:26236990] +is_a: GO:0106295 ! resolvin biosynthetic process + +[Term] +id: GO:0106299 +name: resolution phase response +namespace: biological_process +def: "An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function." [PMID:28087575] +comment: Acute inflammatory response(s) are self-limited, resolve on their own and classically divide into initiation and resolution phases. SPMs are a superfamily of proresolving mediators that include resolvins (Rvs), protectins (PDs), maresins (MaRs) and lipoxins (LXs). +is_a: GO:0002526 ! acute inflammatory response + +[Term] +id: GO:0106300 +name: protein-DNA covalent cross-linking repair +namespace: biological_process +def: "The removal of covalent cross-link between DNA and a protein." [PMID:31921408] +synonym: "resolution of protein-DNA covalent cross-linking" EXACT [] +is_a: GO:0006281 ! DNA repair + +[Term] +id: GO:0106301 +name: arachidonic acid 5,6-epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid." [PMID:10491410, PMID:8631948, RHEA:49936] +xref: RHEA:49936 +is_a: GO:0008392 ! arachidonic acid epoxygenase activity + +[Term] +id: GO:0106302 +name: arachidonic acid 8,9-epoxygenase activity +namespace: molecular_function +def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid." [PMID:10491410, PMID:8246128, RHEA:64984] +xref: RHEA:64984 +is_a: GO:0008392 ! arachidonic acid epoxygenase activity + +[Term] +id: GO:0106303 +name: mannogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:12902334, PMID:16766650, PMID:31513773, PMID:31662278] +synonym: "beta-1,2-mannan metabolic process" RELATED [] +synonym: "mannogen metabolism" RELATED [] +is_a: GO:0044264 ! cellular polysaccharide metabolic process + +[Term] +id: GO:0106304 +name: mannogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:16766650, PMID:31513773, PMID:31662278] +synonym: "beta-1,2-mannan biosynthetic process" RELATED [] +synonym: "mannogen anabolism" RELATED [] +synonym: "mannogen biosynthesis" RELATED [] +synonym: "mannogen formation" RELATED [] +synonym: "mannogen synthesis" RELATED [] +is_a: GO:0106303 ! mannogen metabolic process + +[Term] +id: GO:0106305 +name: mannogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania." [PMID:12902334, PMID:31513773, PMID:31662278] +synonym: "beta-1,2-mannan catabolic process" RELATED [] +synonym: "beta-1,2-mannan catabolism" RELATED [] +synonym: "mannogen breakdown" RELATED [] +synonym: "mannogen catabolism" RELATED [] +synonym: "mannogen degradation" RELATED [] +is_a: GO:0106303 ! mannogen metabolic process + +[Term] +id: GO:0106309 +name: progesterone 21-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [PMID:25855791, RHEA:50304] +xref: RHEA:50304 +is_a: GO:0004509 ! steroid 21-monooxygenase activity + +[Term] +id: GO:0106310 +name: protein serine kinase activity +namespace: molecular_function +def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate." [RHEA:17989] +comment: Note that this term is to annotate proteins the specifically phosphorylate a serine residue on a protein. An example is human PIKFYVE (UniProt:Q9Y2I7). For dual specificity protein kinases, use 'protein serine/threonine kinase activity' ; GO:0004712. +xref: RHEA:17989 +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:0106312 +name: methylenetetrahydrofolate reductase NADH activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+." [RHEA:19821] +xref: RHEA:19821 +is_a: GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity + +[Term] +id: GO:0106313 +name: methylenetetrahydrofolate reductase NADPH activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+." [RHEA:19817] +xref: RHEA:19817 +is_a: GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity + +[Term] +id: GO:0106314 +name: nitrite reductase NADPH activity +namespace: molecular_function +def: "Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+." [RHEA:24632] +xref: RHEA:24632 +is_a: GO:0008942 ! nitrite reductase [NAD(P)H] activity + +[Term] +id: GO:0106316 +name: nitrite reductase NADH activity +namespace: molecular_function +def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+." [RHEA:24628] +xref: RHEA:24628 +is_a: GO:0008942 ! nitrite reductase [NAD(P)H] activity + +[Term] +id: GO:0106317 +name: methane monooxygenase NADH activity +namespace: molecular_function +def: "Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O." [RHEA:13637] +xref: EC:1.14.13.25 +xref: RHEA:13637 +is_a: GO:0015049 ! methane monooxygenase activity + +[Term] +id: GO:0106318 +name: methane monooxygenase NADPH activity +namespace: molecular_function +def: "Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O." [RHEA:13641] +xref: EC:1.14.13.25 +xref: RHEA:13641 +is_a: GO:0015049 ! methane monooxygenase activity + +[Term] +id: GO:0106319 +name: (R)-limonene 1,2-monooxygenase NADH activity +namespace: molecular_function +def: "Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide." [RHEA:26093] +xref: EC:1.14.13.107 +xref: RHEA:26093 +is_a: GO:0018635 ! (R)-limonene 1,2-monooxygenase activity + +[Term] +id: GO:0106320 +name: (R)-limonene 1,2-monooxygenase NADPH activity +namespace: molecular_function +def: "Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide." [RHEA:26097] +xref: EC:1.14.13.107 +xref: RHEA:26097 +is_a: GO:0018635 ! (R)-limonene 1,2-monooxygenase activity + +[Term] +id: GO:0106321 +name: S-(hydroxymethyl)glutathione dehydrogenase NADP activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+." [RHEA:19981] +xref: EC:1.1.1.284 +xref: RHEA:19981 +is_a: GO:0051903 ! S-(hydroxymethyl)glutathione dehydrogenase activity + +[Term] +id: GO:0106322 +name: S-(hydroxymethyl)glutathione dehydrogenase NAD activity +namespace: molecular_function +def: "Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+." [RHEA:19985] +xref: EC:1.1.1.284 +xref: RHEA:19985 +is_a: GO:0051903 ! S-(hydroxymethyl)glutathione dehydrogenase activity + +[Term] +id: GO:0106323 +name: (S)-limonene 1,2-monooxygenase NADPH activity +namespace: molecular_function +def: "Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide." [RHEA:26085] +xref: RHEA:26085 +is_a: GO:0052601 ! (S)-limonene 1,2-monooxygenase activity + +[Term] +id: GO:0106324 +name: (S)-limonene 1,2-monooxygenase NADH activity +namespace: molecular_function +def: "Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide." [RHEA:26089] +xref: RHEA:26089 +is_a: GO:0052601 ! (S)-limonene 1,2-monooxygenase activity + +[Term] +id: GO:0106325 +name: acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP." [RHEA:56188] +xref: EC:2.4.1.148 +xref: RHEA:56188 +is_a: GO:0047225 ! acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity + +[Term] +id: GO:0106326 +name: acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP." [RHEA:56192] +xref: EC:2.4.1.148 +xref: RHEA:56192 +is_a: GO:0047225 ! acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity + +[Term] +id: GO:0106327 +name: acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP." [RHEA:46880] +xref: EC:2.4.1.147 +xref: RHEA:46880 +is_a: GO:0047224 ! acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity + +[Term] +id: GO:0106328 +name: acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP." [RHEA:46884] +xref: EC:2.4.1.147 +xref: RHEA:46884 +is_a: GO:0047224 ! acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity + +[Term] +id: GO:0106329 +name: L-phenylalaine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+)." [RHEA:61240] +xref: RHEA:61240 +is_a: GO:0001716 ! L-amino-acid oxidase activity + +[Term] +id: GO:0106330 +name: sialate 9-O-acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate." [RHEA:22600] +xref: EC:3.1.1.53 +xref: RHEA:22600 +is_a: GO:0001681 ! sialate O-acetylesterase activity + +[Term] +id: GO:0106331 +name: sialate 4-O-acetylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate." [RHEA:25564] +xref: EC:3.1.1.53 +xref: RHEA:25564 +is_a: GO:0001681 ! sialate O-acetylesterase activity + +[Term] +id: GO:0106332 +name: ds/ssDNA junction-specific dsDNA endonuclease activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction." [PMID:14528010] +is_a: GO:1990238 ! double-stranded DNA endodeoxyribonuclease activity + +[Term] +id: GO:0106333 +name: subcortical maternal complex +namespace: cellular_component +def: "Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex." [PMID:18804437, PMID:28992324] +synonym: "SCMC" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0106334 +name: 3'-deoxyribose phosphate lyase activity +namespace: molecular_function +def: "Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate." [GOC:mah, PMID:21276450, PMID:22084197, PMID:22375014] +synonym: "3'-dRP lyase" RELATED [] +synonym: "3'-dRP lyase activity" RELATED [] +is_a: GO:0016829 ! lyase activity +is_a: GO:0140097 ! catalytic activity, acting on DNA + +[Term] +id: GO:0106335 +name: tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine." [PMID:20123966, RHEA:43208] +xref: EC:2.1.1.229 +xref: RHEA:43208 +is_a: GO:0008168 ! methyltransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0106336 +name: yolk syncytial layer development +namespace: biological_process +def: "The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm." [PMID:29180571] +comment: The "yolk syncytial layer" structure can be found in Teleostei, Myxini, Chondrichthyes, Lepisosteiformes and Cephalopoda according. +synonym: "YSL development" RELATED [] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:0106339 +name: tRNA (cytidine 32-2'-O)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA." [PMID:25404562] +is_a: GO:0052666 ! tRNA (cytosine-2'-O-)-methyltransferase activity + +[Term] +id: GO:0106340 +name: tRNA (guanosine 32-2'-O)-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 32 in tRNA." [PMID:25404562] +is_a: GO:0009020 ! tRNA (guanosine-2'-O-)-methyltransferase activity + +[Term] +id: GO:0106341 +name: omega-hydroxyceramide transacylase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine." [PMID:28248318, RHEA:55264] +xref: RHEA:55264 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0106342 +name: omega-hydroxyceramide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide." [PMID:28248318] +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:0106343 +name: glutarate dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2." [PMID:30498244, RHEA:13821] +xref: EC:1.14.11.64 +xref: RHEA:13821 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0106344 +name: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP +namespace: molecular_function +def: "Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]." [PMID:22568620, RHEA:65756] +xref: RHEA:65756 +is_a: GO:0016740 ! transferase activity + +[Term] +id: GO:0106345 +name: glyoxylate reductase activity +namespace: molecular_function +def: "Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H." [GOC:curators, PMID:3548703] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0106346 +name: snRNA methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule." [PMID:27573892] +is_a: GO:0008173 ! RNA methyltransferase activity + +[Term] +id: GO:0106347 +name: U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+." [PMID:31913360, RHEA:62672] +xref: RHEA:62672 +is_a: GO:0106346 ! snRNA methyltransferase activity + +[Term] +id: GO:0106348 +name: U2 snRNA adenosine m6 methytransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+." [PMID:32637152] +is_a: GO:0106346 ! snRNA methyltransferase activity + +[Term] +id: GO:0106349 +name: snRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule." [PMID:21823225] +is_a: GO:0001510 ! RNA methylation +is_a: GO:0040031 ! snRNA modification + +[Term] +id: GO:0106350 +name: octaprenyl pyrophosphate synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate." [PMID:3519603, PMID:8037730, RHEA:27798] +xref: EC:2.5.1.90 +xref: RHEA:27798 +is_a: GO:0004659 ! prenyltransferase activity + +[Term] +id: GO:0106351 +name: aspartate dehydrogenase NAD activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + H2O + NAD+ = oxaloacetate + NH3 + NADH+ H+." [RHEA:11788] +xref: RHEA:11788 +is_a: GO:0033735 ! aspartate dehydrogenase activity + +[Term] +id: GO:0106352 +name: aspartate dehydrogenase NADP activity +namespace: molecular_function +def: "Catalysis of the reaction: L-aspartate + H2O + NADP+ = oxaloacetate + NH3 + NADPH+ H+." [RHEA:11784] +xref: RHEA:11784 +is_a: GO:0033735 ! aspartate dehydrogenase activity + +[Term] +id: GO:0106354 +name: tRNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading defective or aberrant tRNAs." [GOC:mah, PMID:32841241] +is_a: GO:0016078 ! tRNA catabolic process +is_a: GO:0071025 ! RNA surveillance + +[Term] +id: GO:0106355 +name: 4-hydroxybenzoate 3-monooxygenase [NADH] activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+." [RHEA:19473] +xref: RHEA:19473 +is_a: GO:0018671 ! 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity + +[Term] +id: GO:0106356 +name: 4-hydroxybenzoate 3-monooxygenase [NADPH] activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+." [RHEA:19477] +xref: RHEA:19477 +is_a: GO:0018671 ! 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity + +[Term] +id: GO:0106357 +name: glycerol-1-phosphate dehydrogenase [NAD+] activity +namespace: molecular_function +def: "Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH." [RHEA:21412] +xref: RHEA:21412 +is_a: GO:0050492 ! glycerol-1-phosphate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0106358 +name: glycerol-1-phosphate dehydrogenase [NADP+] activity +namespace: molecular_function +def: "Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH." [RHEA:21416] +xref: RHEA:21416 +is_a: GO:0050492 ! glycerol-1-phosphate dehydrogenase [NAD(P)+] activity + +[Term] +id: GO:0106359 +name: 2-hydroxyacyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: A 2-hydroxyacyl-CoA = formyl-CoA + a propanol." [PMID:21708296, PMID:28289220] +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0106360 +name: 2-hydroxy-3-methylhexadecanoyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA." [RHEA:25379] +xref: RHEA:25379 +is_a: GO:0106359 ! 2-hydroxyacyl-CoA lyase activity + +[Term] +id: GO:0106361 +name: protein-arginine rhamnosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]." [GOC:sp, PMID:25686373, PMID:26060278, RHEA:66692] +xref: RHEA:66692 +is_a: GO:0046527 ! glucosyltransferase activity + +[Term] +id: GO:0106362 +name: protein-arginine N-acetylglucosaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP." [GOC:sp, PMID:23955153, PMID:30619781, RHEA:66632] +xref: RHEA:66632 +is_a: GO:0016262 ! protein N-acetylglucosaminyltransferase activity + +[Term] +id: GO:0106363 +name: protein-cysteine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]." [GOC:sp, PMID:21481189, PMID:22158122, PMID:24235145, PMID:25412445, RHEA:66544] +xref: RHEA:66544 +is_a: GO:0008172 ! S-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0106364 +name: 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity +namespace: molecular_function +def: "4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]." [PMID:21944752, RHEA:20361] +xref: RHEA:20361 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106365 +name: beta-carotene isomerase activity +namespace: molecular_function +def: "Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene." [PMID:19470589, PMID:22422982, RHEA:34455] +xref: EC:5.2.1.14 +xref: RHEA:34455 +is_a: GO:0016859 ! cis-trans isomerase activity + +[Term] +id: GO:0106366 +name: guanosine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + guanosine = ADP + GMP." [PMID:10879466, PMID:7665468, RHEA:27710] +xref: EC:2.7.1.73 +xref: RHEA:27710 +is_a: GO:0016301 ! kinase activity +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0106367 +name: (deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor +namespace: molecular_function +def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP." [PMID:20497505, RHEA:62128] +xref: RHEA:62128 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0106368 +name: (deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor +namespace: molecular_function +def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP." [PMID:20497505, RHEA:62132] +xref: RHEA:62132 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0106369 +name: (deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor +namespace: molecular_function +def: "Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP." [PMID:20497505, RHEA:62124] +xref: RHEA:62124 +is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor +is_a: GO:0019205 ! nucleobase-containing compound kinase activity + +[Term] +id: GO:0106370 +name: protein-L-histidine N-pros-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine." [PMID:33563959, RHEA:67076] +xref: RHEA:67076 +is_a: GO:0008170 ! N-methyltransferase activity +is_a: GO:0008276 ! protein methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:0106371 +name: fluorescent chlorophyll catabolite monooxygenase (deformylase) activity +namespace: molecular_function +def: "Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite." [PMID:23723324, RHEA:67172] +xref: RHEA:67172 +is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0106372 +name: primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC." [PMID:23723324, RHEA:67176] +xref: RHEA:67176 +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:0106373 +name: 3-deoxyglucosone dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH." [PMID:17175089, RHEA:67244] +xref: RHEA:67244 +is_a: GO:0004029 ! aldehyde dehydrogenase (NAD+) activity + +[Term] +id: GO:0106375 +name: deoxynucleoside triphosphate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate." [RHEA:46148] +xref: RHEA:46148 +is_a: GO:0016793 ! triphosphoric monoester hydrolase activity + +[Term] +id: GO:0106376 +name: 2-hydroxyphytanoyl-CoA lyase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA." [PMID:10468558, RHEA:25355] +xref: RHEA:25355 +is_a: GO:0016832 ! aldehyde-lyase activity + +[Term] +id: GO:0106377 +name: 2-hydroxy-ATP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + diphosphate." [PMID:11139615, RHEA:67392] +xref: RHEA:67392 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0106378 +name: 2-hydroxy-dATP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate." [PMID:11139615, RHEA:31583] +xref: RHEA:31583 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0106379 +name: 8-oxo-(d)RTP hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+." [PMID:11139615] +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides + +[Term] +id: GO:0106380 +name: purine ribonucleotide salvage +namespace: biological_process +def: "Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis." [PMID:8864750] +is_a: GO:0009152 ! purine ribonucleotide biosynthetic process +is_a: GO:0032261 ! purine nucleotide salvage + +[Term] +id: GO:0106381 +name: purine deoxyribonucleotide salvage +namespace: biological_process +def: "Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis." [PMID:6605343] +is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process +is_a: GO:0032261 ! purine nucleotide salvage + +[Term] +id: GO:0106383 +name: dAMP salvage +namespace: biological_process +def: "Any process which produces a dAMP from derivatives of it, without de novo synthesis." [PMID:21829339, PMID:6605343] +is_a: GO:0006170 ! dAMP biosynthetic process +is_a: GO:0106381 ! purine deoxyribonucleotide salvage + +[Term] +id: GO:0106384 +name: dGMP salvage +namespace: biological_process +def: "Any process which produces a dGMP from derivatives of it, without de novo synthesis." [PMID:21829339, PMID:6605343] +is_a: GO:0006181 ! dGMP biosynthetic process +is_a: GO:0106381 ! purine deoxyribonucleotide salvage + +[Term] +id: GO:0106385 +name: dIMP salvage +namespace: biological_process +def: "Any process which produces a dIMP from derivatives of it, without de novo synthesis." [PMID:8692979] +is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process +is_a: GO:0106381 ! purine deoxyribonucleotide salvage + +[Term] +id: GO:0106386 +name: (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity +namespace: molecular_function +def: "Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH." [PMID:19571038, PMID:25203508] +xref: EC:1.1.1.n12 +xref: RHEA:32711 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0106387 +name: 'de novo' GMP biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate." [PMID:25605736] +synonym: "'de novo' guanosine 5'-monophosphate biosynthetic process" EXACT [] +is_a: GO:0006177 ! GMP biosynthetic process + +[Term] +id: GO:0106388 +name: 18S rRNA aminocarboxypropyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine." [PMID:27084949] +xref: RHEA:63296 +is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups +is_a: GO:0140102 ! catalytic activity, acting on a rRNA + +[Term] +id: GO:0106389 +name: ecdysteroid 22-kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+." [PMID:16899460] +xref: MetaCyc:RXN-14755 +is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor + +[Term] +id: GO:0106391 +name: bI4 intron splicing complex +namespace: cellular_component +def: "A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing." [GOC:lnp, PMID:19622748] +xref: Intact:EBI-16420264 +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:0106392 +name: bI3 intron splicing complex +namespace: cellular_component +def: "Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing." [GOC:lnp, PMID:11773622] +xref: Intact:EBI-16426213 +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:0106393 +name: regulation of palmitic acid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:1900534 ! palmitic acid catabolic process + +[Term] +id: GO:0106394 +name: negative regulation of palmitic acid catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:0106393 ! regulation of palmitic acid catabolic process +relationship: negatively_regulates GO:1900534 ! palmitic acid catabolic process + +[Term] +id: GO:0106395 +name: positive regulation of palmitic acid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process." [PMID:14677856] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:0106393 ! regulation of palmitic acid catabolic process +relationship: positively_regulates GO:1900534 ! palmitic acid catabolic process + +[Term] +id: GO:0106396 +name: regulation of R7 cell fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552] +is_a: GO:0010453 ! regulation of cell fate commitment +relationship: regulates GO:0007465 ! R7 cell fate commitment + +[Term] +id: GO:0106397 +name: positive regulation of R7 cell fate commitment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0106396 ! regulation of R7 cell fate commitment +relationship: positively_regulates GO:0007465 ! R7 cell fate commitment + +[Term] +id: GO:0106398 +name: negative regulation of R7 cell fate commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment." [GOC:ha, PMID:22878552] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0106396 ! regulation of R7 cell fate commitment +relationship: negatively_regulates GO:0007465 ! R7 cell fate commitment + +[Term] +id: GO:0106399 +name: acyl-coenzyme A diphosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: an acyl-CoA + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H(+)." [PMID:32915949, RHEA:50044] +xref: RHEA:50044 +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0106400 +name: double-strand break repair via transcription-associated homologous recombination +namespace: biological_process +def: "A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair." [PMID:25186730] +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:0106402 +name: Lewis x epitope biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a Lewis x epitope, a trisaccharide (beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-beta-D-glucosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system. The related Lewis x epitope is formed by alpha(1,3) fucosylation of the N-acetylglucosaminyl residue of a type 2 histo-blood group antigen precursor disaccharide." [PMID:16973732, PMID:23000574] +synonym: "sialyl-Lewis X biosynthetic process" RELATED [] +synonym: "sLeX biosynthetic process" RELATED [] +is_a: GO:0005975 ! carbohydrate metabolic process + +[Term] +id: GO:0106405 +name: isoprenoid diphosphate phosphatase activity +namespace: molecular_function +def: "Catalysis of the dephosphorylation of isoprenoid diphosphates." [PMID:33246356] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0106407 +name: Glc2Man9GlcNAc2 oligosaccharide glucosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: Glc(2)Man(9)GlcNAc(2)-[protein] + H(2)O = GlcMan(9)GlcNAc(2)-[protein] + beta-D-glucopyranose." [PMID:30389790] +comment: Trims Glc alpha 1,3 Glc bond in Glc2Man9GlcNAc2 oligosaccharide in inmature glycoproteins. +synonym: "Glucosidase II" BROAD [] +is_a: GO:0004573 ! Glc3Man9GlcNAc2 oligosaccharide glucosidase activity + +[Term] +id: GO:0106408 +name: diadenylate cyclase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate." [PMID:30884174, RHEA:35655] +synonym: "cyclic-di-AMP synthase" EXACT [EC:2.7.7.85] +xref: EC:2.7.7.85 +xref: MetaCyc:RXN-14338 +xref: RHEA:35655 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0106409 +name: cyclic-di-AMP phosphodiesterase activity +namespace: molecular_function +def: "Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+." [PMID:21909268, RHEA:54420] +xref: EC:3.1.4.59 +xref: MetaCyc:RXN-19814 +xref: RHEA:54420 +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0106410 +name: box C/D RNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of a box C/D RNA molecule." [PMID:34352089] +is_a: GO:0034471 ! ncRNA 5'-end processing +is_a: GO:0034963 ! box C/D RNA processing + +[Term] +id: GO:0106411 +name: XMP 5'-nucleosidase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine." [PMID:34824243, RHEA:28530] +xref: EC:3.1.3.5 +xref: MetaCyc:XMPXAN-RXN +xref: RHEA:28530 +is_a: GO:0008253 ! 5'-nucleotidase activity + +[Term] +id: GO:0106413 +name: dihydrouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: RNA-uracil + acceptor = RNA-dihydrouridine + reduced acceptor." [PMID:12581659, PMID:25073379] +is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors + +[Term] +id: GO:0106414 +name: mRNA dihydrouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: mRNA-uracil + acceptor = mRNA-dihydrouridine + reduced acceptor." [PMID:34798057] +is_a: GO:0106413 ! dihydrouridine synthase activity + +[Term] +id: GO:0106415 +name: muramoyltetrapeptide carboxypeptidase activity +namespace: molecular_function +def: "GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H(2)O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine." [PMID:10428950, PMID:15361936] +xref: EC:3.4.17.13 +xref: RHEA:48688 +is_a: GO:0004180 ! carboxypeptidase activity + +[Term] +id: GO:0106417 +name: dopaminechrome tautomerase activity +namespace: molecular_function +def: "Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole." [PMID:34388859] +is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds + +[Term] +id: GO:0110001 +name: toxin-antitoxin complex +namespace: cellular_component +def: "A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon." [GOC:bhm, PMID:16109374, PMID:25093388] +comment: An example is YoeB (P69348) in Escherichia coli in PMID:16109374 (inferred by direct evidence). +is_a: GO:0017053 ! transcription repressor complex + +[Term] +id: GO:0110002 +name: regulation of tRNA methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation." [GOC:vw, PMID:23074192] +is_a: GO:2000235 ! regulation of tRNA processing +relationship: regulates GO:0030488 ! tRNA methylation + +[Term] +id: GO:0110003 +name: regulation of tRNA C5-cytosine methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192] +is_a: GO:0110002 ! regulation of tRNA methylation +relationship: regulates GO:0002946 ! tRNA C5-cytosine methylation + +[Term] +id: GO:0110004 +name: positive regulation of tRNA methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA methylation." [GOC:vw, PMID:23074192] +is_a: GO:0110002 ! regulation of tRNA methylation +is_a: GO:2000237 ! positive regulation of tRNA processing +relationship: positively_regulates GO:0030488 ! tRNA methylation + +[Term] +id: GO:0110005 +name: positive regulation of tRNA C5-cytosine methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation." [GOC:vw, PMID:23074192] +is_a: GO:0110003 ! regulation of tRNA C5-cytosine methylation +is_a: GO:0110004 ! positive regulation of tRNA methylation +relationship: positively_regulates GO:0002946 ! tRNA C5-cytosine methylation + +[Term] +id: GO:0110008 +name: ncRNA deadenylation +namespace: biological_process +def: "Shortening of the poly(A) tail of a nuclear-transcribed ncRNA." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:26950371] +is_a: GO:0034660 ! ncRNA metabolic process + +[Term] +id: GO:0110009 +name: formin-nucleated actin cable organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable." [GOC:mah] +is_a: GO:0061572 ! actin filament bundle organization + +[Term] +id: GO:0110010 +name: basolateral protein secretion +namespace: biological_process +def: "The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base." [GOC:ha, PMID:27404358] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:0110011 +name: regulation of basement membrane organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane." [GOC:ha, PMID:27404358] +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: regulates GO:0071711 ! basement membrane organization + +[Term] +id: GO:0110012 +name: protein localization to P-body +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, a P-body." [GOC:mah, PMID:28031482] +synonym: "protein localisation to P-body" EXACT [GOC:mah] +synonym: "protein localization to cytoplasmic mRNA processing body" EXACT [] +synonym: "protein localization to P body" EXACT [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:0110013 +name: positive regulation of aggregation involved in sorocarp development +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development +relationship: positively_regulates GO:0031152 ! aggregation involved in sorocarp development + +[Term] +id: GO:0110014 +name: negative regulation of aggregation involved in sorocarp development +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:rjd, PMID:28257811] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development +relationship: negatively_regulates GO:0031152 ! aggregation involved in sorocarp development + +[Term] +id: GO:0110015 +name: positive regulation of elastin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:0060310 ! regulation of elastin catabolic process +is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process +relationship: positively_regulates GO:0060309 ! elastin catabolic process + +[Term] +id: GO:0110016 +name: B-WICH complex +namespace: cellular_component +def: "A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself." [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184] +comment: An example is BAZ1B (Q9UIG0) in human in PMID:16603771 (by IPI). +is_a: GO:0070603 ! SWI/SNF superfamily-type complex +relationship: part_of GO:0005730 ! nucleolus + +[Term] +id: GO:0110017 +name: cap-independent translational initiation of linear mRNA +namespace: biological_process +def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [GOC:kmv] +is_a: GO:0002190 ! cap-independent translational initiation + +[Term] +id: GO:0110018 +name: cap-independent translational initiation of circular RNA +namespace: biological_process +def: "The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082] +synonym: "cap-independent translational initiation of circRNA" EXACT [] +is_a: GO:0002190 ! cap-independent translational initiation + +[Term] +id: GO:0110019 +name: IRES-dependent translational initiation of circular RNA +namespace: biological_process +def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation." [GOC:sp, PMID:28281539, PMID:28344080, PMID:28344082] +synonym: "IRES-dependent translational initiation of circRNA" EXACT [] +is_a: GO:0110018 ! cap-independent translational initiation of circular RNA + +[Term] +id: GO:0110020 +name: regulation of actomyosin structure organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin." [GOC:lf, PMID:22790195] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0031032 ! actomyosin structure organization + +[Term] +id: GO:0110021 +name: cardiac muscle myoblast proliferation +namespace: biological_process +def: "The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] +is_a: GO:0051450 ! myoblast proliferation + +[Term] +id: GO:0110022 +name: regulation of cardiac muscle myoblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] +is_a: GO:2000291 ! regulation of myoblast proliferation +relationship: regulates GO:0110021 ! cardiac muscle myoblast proliferation + +[Term] +id: GO:0110023 +name: negative regulation of cardiac muscle myoblast proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] +is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation +is_a: GO:2000818 ! negative regulation of myoblast proliferation +relationship: negatively_regulates GO:0110021 ! cardiac muscle myoblast proliferation + +[Term] +id: GO:0110024 +name: positive regulation of cardiac muscle myoblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26512644] +is_a: GO:0110022 ! regulation of cardiac muscle myoblast proliferation +is_a: GO:2000288 ! positive regulation of myoblast proliferation +relationship: positively_regulates GO:0110021 ! cardiac muscle myoblast proliferation + +[Term] +id: GO:0110025 +name: DNA strand resection involved in replication fork processing +namespace: biological_process +def: "The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing." [GOC:mah, PMID:28475874] +is_a: GO:0006259 ! DNA metabolic process +relationship: part_of GO:0031297 ! replication fork processing + +[Term] +id: GO:0110026 +name: regulation of DNA strand resection involved in replication fork processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0110025 ! DNA strand resection involved in replication fork processing + +[Term] +id: GO:0110027 +name: negative regulation of DNA strand resection involved in replication fork processing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing." [GOC:mah, PMID:28475874] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0110026 ! regulation of DNA strand resection involved in replication fork processing +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0110025 ! DNA strand resection involved in replication fork processing + +[Term] +id: GO:0110028 +name: positive regulation of mitotic spindle organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle organization." [GOC:bhm, PMID:17576815] +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0060236 ! regulation of mitotic spindle organization +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0007052 ! mitotic spindle organization + +[Term] +id: GO:0110029 +name: negative regulation of meiosis I +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:vw] +is_a: GO:0045835 ! negative regulation of meiotic nuclear division +is_a: GO:0060631 ! regulation of meiosis I +relationship: negatively_regulates GO:0007127 ! meiosis I + +[Term] +id: GO:0110030 +name: regulation of G2/MI transition of meiotic cell cycle +namespace: biological_process +def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw] +is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition +is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition +relationship: regulates GO:0008315 ! G2/MI transition of meiotic cell cycle + +[Term] +id: GO:0110031 +name: negative regulation of G2/MI transition of meiotic cell cycle +namespace: biological_process +def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] +is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle +is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition +is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition +relationship: negatively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle + +[Term] +id: GO:0110032 +name: positive regulation of G2/MI transition of meiotic cell cycle +namespace: biological_process +def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle." [GOC:vw, PMID:25492408] +is_a: GO:0110030 ! regulation of G2/MI transition of meiotic cell cycle +is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition +is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition +relationship: positively_regulates GO:0008315 ! G2/MI transition of meiotic cell cycle + +[Term] +id: GO:0110033 +name: regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:al, PMID:24297439] +synonym: "regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:1902659 ! regulation of glucose mediated signaling pathway +relationship: regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway + +[Term] +id: GO:0110034 +name: negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway." [GOC:al, PMID:24297439] +synonym: "negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] +is_a: GO:0106072 ! negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:0110033 ! regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway +is_a: GO:1902660 ! negative regulation of glucose mediated signaling pathway +relationship: negatively_regulates GO:0010619 ! adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway + +[Term] +id: GO:0110035 +name: rDNA spacer replication fork barrier binding, bending +namespace: molecular_function +def: "The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:al, GOC:vw, PMID:27035982] +is_a: GO:0043110 ! rDNA spacer replication fork barrier binding +is_a: GO:0044374 ! sequence-specific DNA binding, bending + +[Term] +id: GO:0110036 +name: C2 domain binding +namespace: molecular_function +def: "Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes." [GOC:sl, PMID:24882364] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:0110037 +name: regulation of nematode male tail tip morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nematode male tail tip morphogenesis, the process in which the anatomical structure of the adult male tail tip is generated and organized." [GOC:rz, PMID:28068334] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0045138 ! nematode male tail tip morphogenesis + +[Term] +id: GO:0110038 +name: negative regulation of nematode male tail tip morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0045138 ! nematode male tail tip morphogenesis + +[Term] +id: GO:0110039 +name: positive regulation of nematode male tail tip morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis." [GOC:rz, PMID:28068334] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0110037 ! regulation of nematode male tail tip morphogenesis +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0045138 ! nematode male tail tip morphogenesis + +[Term] +id: GO:0110040 +name: pharynx morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of the pharynx are generated and organized." [GOC:rz, PMID:20805556] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0110041 +name: regulation of pharynx morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized." [GOC:rz, PMID:20805556] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0110040 ! pharynx morphogenesis + +[Term] +id: GO:0110042 +name: negative regulation of pharynx morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0110041 ! regulation of pharynx morphogenesis +relationship: negatively_regulates GO:0110040 ! pharynx morphogenesis + +[Term] +id: GO:0110043 +name: positive regulation of pharynx morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis." [GOC:rz, PMID:20805556] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0110041 ! regulation of pharynx morphogenesis +relationship: positively_regulates GO:0110040 ! pharynx morphogenesis + +[Term] +id: GO:0110044 +name: regulation of cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143] +synonym: "sexual differentiation" RELATED [PMID:30922219, PMID:32788233] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0110045 +name: negative regulation of cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [GOC:al, PMID:17674143] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +is_a: GO:0110044 ! regulation of cell cycle switching, mitotic to meiotic cell cycle +relationship: negatively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0110046 +name: signal transduction involved in cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "A signal transduction process that contributes to cell cycle switching, mitotic to meiotic cell cycle." [GOC:al, PMID:17674143] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0035556 ! intracellular signal transduction +relationship: part_of GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0110050 +name: deaminated glutathione amidase activity +namespace: molecular_function +def: "Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O = 2-oxoglutarate + L-cysteinylglycine." [GOC:ka, PMID:28373563] +comment: N-(4-oxoglutarate)-L-cysteinylglycine = deaminated glutathione +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0110051 +name: metabolite repair +namespace: biological_process +def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, PMID:23334546, PMID:28373563] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:0110052 +name: toxic metabolite repair +namespace: biological_process +def: "A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites." [GOC:ka, GOC:vw, PMID:23334546] +is_a: GO:0110051 ! metabolite repair +is_a: GO:1990748 ! cellular detoxification + +[Term] +id: GO:0110053 +name: regulation of actin filament organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament organization." [GOC:kmv] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0007015 ! actin filament organization + +[Term] +id: GO:0110054 +name: regulation of actin filament annealing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:15743909, PMID:19244341] +is_a: GO:0110053 ! regulation of actin filament organization + +[Term] +id: GO:0110055 +name: negative regulation of actin filament annealing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:15743909] +is_a: GO:0110054 ! regulation of actin filament annealing + +[Term] +id: GO:0110056 +name: positive regulation of actin filament annealing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments." [GOC:mah, PMID:10585915, PMID:11575927, PMID:19244341] +is_a: GO:0110054 ! regulation of actin filament annealing + +[Term] +id: GO:0110057 +name: regulation of blood vessel endothelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] +is_a: GO:0045601 ! regulation of endothelial cell differentiation +relationship: regulates GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0110058 +name: positive regulation of blood vessel endothelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] +is_a: GO:0045603 ! positive regulation of endothelial cell differentiation +is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation +relationship: positively_regulates GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0110059 +name: negative regulation of blood vessel endothelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:23072816] +is_a: GO:0045602 ! negative regulation of endothelial cell differentiation +is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation +relationship: negatively_regulates GO:0060837 ! blood vessel endothelial cell differentiation + +[Term] +id: GO:0110061 +name: regulation of angiotensin-activated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0038166 ! angiotensin-activated signaling pathway + +[Term] +id: GO:0110062 +name: negative regulation of angiotensin-activated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway +relationship: negatively_regulates GO:0038166 ! angiotensin-activated signaling pathway + +[Term] +id: GO:0110063 +name: positive regulation of angiotensin-activated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway." [GOC:lf, PMID:28784619] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0110061 ! regulation of angiotensin-activated signaling pathway +relationship: positively_regulates GO:0038166 ! angiotensin-activated signaling pathway + +[Term] +id: GO:0110064 +name: lncRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length." [GOC:al, PMID:24493644] +synonym: "lncRNA breakdown" EXACT [] +synonym: "lncRNA catabolism" EXACT [] +synonym: "lncRNA degradation" EXACT [] +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0110065 +name: regulation of interphase mitotic telomere clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919] +synonym: "regulation of mitotic telomere clustering during interphase" EXACT [] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0120110 ! interphase mitotic telomere clustering + +[Term] +id: GO:0110066 +name: negative regulation of interphase mitotic telomere clustering +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase." [GOC:vw, PMID:25778919] +synonym: "negative regulation of mitotic telomere clustering during interphase" EXACT [] +synonym: "telomere dispersion during interphase" EXACT [GOC:vw, PMID:25778919] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0110065 ! regulation of interphase mitotic telomere clustering +relationship: negatively_regulates GO:0120110 ! interphase mitotic telomere clustering + +[Term] +id: GO:0110067 +name: ammonium transmembrane transporter complex +namespace: cellular_component +def: "High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other." [GOC:bhm, PMID:17026539, PMID:23463773] +synonym: "AMT1 complex" NARROW [GOC:bhm] +is_a: GO:0034703 ! cation channel complex + +[Term] +id: GO:0110068 +name: glucosylglycerate phosphorylase activity +namespace: molecular_function +def: "Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate." [GOC:imk, PMID:28754708] +is_a: GO:0004645 ! 1,4-alpha-oligoglucan phosphorylase activity + +[Term] +id: GO:0110069 +name: syncytial embryo cellularization +namespace: biological_process +def: "The separation of a syncytial embryo into individual cells." [GOC:ha, PMID:27226317] +is_a: GO:0007349 ! cellularization +is_a: GO:0051301 ! cell division +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:0110070 +name: cellularization cleavage furrow +namespace: cellular_component +def: "A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells." [GOC:ha, PMID:27226317] +is_a: GO:0098590 ! plasma membrane region + +[Term] +id: GO:0110071 +name: cellularization cleavage furrow invagination front +namespace: cellular_component +def: "The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane." [GOC:ha, PMID:27226317] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0110070 ! cellularization cleavage furrow + +[Term] +id: GO:0110072 +name: apical constriction involved in ventral furrow formation +namespace: biological_process +def: "The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [GOC:ha, PMID:28495958] +is_a: GO:0003384 ! apical constriction involved in gastrulation +relationship: part_of GO:0007370 ! ventral furrow formation + +[Term] +id: GO:0110073 +name: regulation of apical constriction involved in ventral furrow formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958] +is_a: GO:0010470 ! regulation of gastrulation +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: regulates GO:0110072 ! apical constriction involved in ventral furrow formation + +[Term] +id: GO:0110074 +name: positive regulation of apical constriction involved in ventral furrow formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation." [GOC:ha, PMID:28495958] +is_a: GO:0110073 ! regulation of apical constriction involved in ventral furrow formation +is_a: GO:1903116 ! positive regulation of actin filament-based movement +relationship: positively_regulates GO:0110072 ! apical constriction involved in ventral furrow formation + +[Term] +id: GO:0110075 +name: regulation of ferroptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0097707 ! ferroptosis + +[Term] +id: GO:0110076 +name: negative regulation of ferroptosis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis." [GOC:sp, PMID:24439385, PMID:25402683, PMID:29290465] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:0110075 ! regulation of ferroptosis +relationship: negatively_regulates GO:0097707 ! ferroptosis + +[Term] +id: GO:0110077 +name: vesicle-mediated intercellular transport +namespace: biological_process +def: "A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane." [GOC:sp, PMID:29328915, PMID:29328916] +is_a: GO:0010496 ! intercellular transport +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0110078 +name: TTT complex +namespace: cellular_component +def: "A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209)." [GOC:lnp, PMID:20810650, PMID:22505622, PMID:28827813] +synonym: "Tel2-Tti1-Tti2" EXACT [GOC:lnp, PMID:28827813] +synonym: "TELO2-TTI1-TTI2" EXACT [GOC:lnp] +synonym: "Triple T complex" EXACT [GOC:lnp, PMID:20810650] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0110079 +name: regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:1901342 ! regulation of vasculature development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060674 ! placenta blood vessel development + +[Term] +id: GO:0110080 +name: positive regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0110079 ! regulation of placenta blood vessel development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060674 ! placenta blood vessel development + +[Term] +id: GO:0110081 +name: negative regulation of placenta blood vessel development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27748453] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0110079 ! regulation of placenta blood vessel development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060674 ! placenta blood vessel development + +[Term] +id: GO:0110082 +name: regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:1901900 ! regulation of protein localization to cell division site +relationship: regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly + +[Term] +id: GO:0110083 +name: positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly + +[Term] +id: GO:0110084 +name: negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly." [GOC:vw, PMID:29343550] +is_a: GO:0110082 ! regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:1903476 ! protein localization to cell division site involved in mitotic actomyosin contractile ring assembly + +[Term] +id: GO:0110085 +name: mitotic actomyosin contractile ring +namespace: cellular_component +def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:vw, PMID:27505246] +is_a: GO:0005826 ! actomyosin contractile ring + +[Term] +id: GO:0110086 +name: meiotic actomyosin contractile ring +namespace: cellular_component +def: "A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis." [GOC:vw, PMID:22526418] +is_a: GO:0005826 ! actomyosin contractile ring + +[Term] +id: GO:0110087 +name: obsolete suppression by virus of host protease activator activity +namespace: biological_process +def: "OBSOLETE. Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protease activator activity." [PMID:23303392] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true + +[Term] +id: GO:0110088 +name: hippocampal neuron apoptotic process +namespace: biological_process +def: "Any apoptotic process that occurs in a hippocampal neuron." [GOC:sl, PMID:18940801] +is_a: GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:0110089 +name: regulation of hippocampal neuron apoptotic process +namespace: biological_process +def: "Any process that modulates the occurrence or rate of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] +is_a: GO:0043523 ! regulation of neuron apoptotic process +relationship: regulates GO:0110088 ! hippocampal neuron apoptotic process + +[Term] +id: GO:0110090 +name: positive regulation of hippocampal neuron apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] +is_a: GO:0043525 ! positive regulation of neuron apoptotic process +is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process +relationship: positively_regulates GO:0110088 ! hippocampal neuron apoptotic process + +[Term] +id: GO:0110091 +name: negative regulation of hippocampal neuron apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons." [GOC:sl, PMID:18940801] +is_a: GO:0043524 ! negative regulation of neuron apoptotic process +is_a: GO:0110089 ! regulation of hippocampal neuron apoptotic process +relationship: negatively_regulates GO:0110088 ! hippocampal neuron apoptotic process + +[Term] +id: GO:0110092 +name: nucleus leading edge +namespace: cellular_component +def: "The area of a motile nucleus closest to the direction of movement." [GOC:al, GOC:mah, GOC:vw, PMID:15030757, PMID:24335254] +synonym: "horsetail nucleus leading edge" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0110093 +name: nucleus lagging edge +namespace: cellular_component +def: "The area of a motile nucleus furthest from the direction of movement." [GOC:kmv, PMID:24335254] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0110094 +name: polyphosphate-mediated signaling +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another using polyphosphate as the signal." [GOC:rjd, PMID:27519410, PMID:28584190] +synonym: "polyphosphate signaling" EXACT [GOC:rjd] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0110095 +name: cellular detoxification of aldehyde +namespace: biological_process +def: "Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw, PMID:25656103] +is_a: GO:1990748 ! cellular detoxification +relationship: part_of GO:0110096 ! cellular response to aldehyde + +[Term] +id: GO:0110096 +name: cellular response to aldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus." [GOC:vw, PMID:25656103] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:0110097 +name: regulation of calcium import into the mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] +is_a: GO:0090279 ! regulation of calcium ion import +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +relationship: regulates GO:0036444 ! calcium import into the mitochondrion + +[Term] +id: GO:0110098 +name: positive regulation of calcium import into the mitochondrion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion." [GOC:sl, PMID:24085037] +is_a: GO:0090280 ! positive regulation of calcium ion import +is_a: GO:0110097 ! regulation of calcium import into the mitochondrion +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +relationship: positively_regulates GO:0036444 ! calcium import into the mitochondrion + +[Term] +id: GO:0110099 +name: negative regulation of calcium import into the mitochondrion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion." [GOC:sl, PMID:24085037] +is_a: GO:0090281 ! negative regulation of calcium ion import +is_a: GO:0110097 ! regulation of calcium import into the mitochondrion +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +relationship: negatively_regulates GO:0036444 ! calcium import into the mitochondrion + +[Term] +id: GO:0110100 +name: spindle pole body separation +namespace: biological_process +def: "The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble." [GOC:vw] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0051300 ! spindle pole body organization + +[Term] +id: GO:0110101 +name: L-valine transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of L-valine into the vacuole across the vacuolar membrane." [GOC:al, PMID:20944394] +is_a: GO:0034491 ! neutral amino acid transmembrane import into vacuole +is_a: GO:1903785 ! L-valine transmembrane transport + +[Term] +id: GO:0110102 +name: ribulose bisphosphate carboxylase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ribulose bisphosphate carboxylase complex." [GOC:krc, GOC:tb, PMID:29396988, PMID:29589905] +synonym: "RuBisCO assembly" EXACT [GOC:krc] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0110103 +name: RNA polymerase II termination complex +namespace: cellular_component +def: "A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end." [GOC:lnp, PMID:23200120, PMID:25722373] +comment: In S. cerevisiae, this complex is formed by RAI1 and RAT1; in H. sapiens it is formed by Twi12, Xrn2 and Tan1. +synonym: "TXT complex" EXACT [PMID:23084833] +is_a: GO:0140513 ! nuclear protein-containing complex +is_a: GO:1905354 ! exoribonuclease complex + +[Term] +id: GO:0110104 +name: mRNA alternative polyadenylation +namespace: biological_process +def: "The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals)." [GOC:ans, PMID:28453393, PMID:29276085] +is_a: GO:1900363 ! regulation of mRNA polyadenylation + +[Term] +id: GO:0110105 +name: mRNA cleavage and polyadenylation specificity factor complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex." [GOC:mah, PMID:27401558] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0031123 ! RNA 3'-end processing + +[Term] +id: GO:0110107 +name: regulation of imaginal disc-derived wing vein specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007474 ! imaginal disc-derived wing vein specification + +[Term] +id: GO:0110108 +name: positive regulation of imaginal disc-derived wing vein specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification +relationship: positively_regulates GO:0007474 ! imaginal disc-derived wing vein specification + +[Term] +id: GO:0110109 +name: negative regulation of imaginal disc-derived wing vein specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification." [GOC:ha, PMID:11861482] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0110107 ! regulation of imaginal disc-derived wing vein specification +relationship: negatively_regulates GO:0007474 ! imaginal disc-derived wing vein specification + +[Term] +id: GO:0110110 +name: positive regulation of animal organ morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: positively_regulates GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0110111 +name: negative regulation of animal organ morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis." [GOC:kmv] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: negatively_regulates GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:0110112 +name: regulation of lipid transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0032409 ! regulation of transporter activity + +[Term] +id: GO:0110113 +name: positive regulation of lipid transporter activity +namespace: biological_process +def: "Any process that increases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0110112 ! regulation of lipid transporter activity + +[Term] +id: GO:0110114 +name: negative regulation of lipid transporter activity +namespace: biological_process +def: "Any process that decreases the frequency, rate, or extent of lipid transporter activity." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27365390] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0110112 ! regulation of lipid transporter activity + +[Term] +id: GO:0110115 +name: Cdr2 medial cortical node complex +namespace: cellular_component +def: "A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase." [GOC:vw, PMID:29514920] +synonym: "interphase cortical node" EXACT [GOC:vw] +synonym: "interphase node" EXACT [GOC:vw] +is_a: GO:1902911 ! protein kinase complex +relationship: part_of GO:0071341 ! medial cortical node + +[Term] +id: GO:0110116 +name: regulation of compound eye photoreceptor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] +is_a: GO:0046532 ! regulation of photoreceptor cell differentiation +relationship: regulates GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0110117 +name: positive regulation of compound eye photoreceptor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] +is_a: GO:0046534 ! positive regulation of photoreceptor cell differentiation +is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation +relationship: positively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0110118 +name: negative regulation of compound eye photoreceptor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation." [GOC:ha, PMID:16377567] +is_a: GO:0046533 ! negative regulation of photoreceptor cell differentiation +is_a: GO:0110116 ! regulation of compound eye photoreceptor cell differentiation +relationship: negatively_regulates GO:0001751 ! compound eye photoreceptor cell differentiation + +[Term] +id: GO:0110119 +name: positive regulation of very-low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:25510864] +is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance +is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance +relationship: positively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance + +[Term] +id: GO:0110120 +name: gamma-tubulin complex localization to nuclear side of mitotic spindle pole body +namespace: biological_process +def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body." [GOC:vw, PMID:19942852] +is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body + +[Term] +id: GO:0110121 +name: gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body +namespace: biological_process +def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body." [GOC:vw, PMID:19001497] +is_a: GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body + +[Term] +id: GO:0110122 +name: myotube cell migration +namespace: biological_process +def: "The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse." [GOC:ha, PMID:29122742] +is_a: GO:0014812 ! muscle cell migration + +[Term] +id: GO:0110123 +name: regulation of myotube cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0110122 ! myotube cell migration + +[Term] +id: GO:0110124 +name: positive regulation of myotube cell migration +namespace: biological_process +def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0110123 ! regulation of myotube cell migration +relationship: positively_regulates GO:0110122 ! myotube cell migration + +[Term] +id: GO:0110125 +name: negative regulation of myotube cell migration +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration." [GOC:ha, PMID:29122742] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0110123 ! regulation of myotube cell migration +relationship: negatively_regulates GO:0110122 ! myotube cell migration + +[Term] +id: GO:0110126 +name: phloem loading +namespace: biological_process +def: "The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:lr, PMID:19025382] +is_a: GO:0010233 ! phloem transport + +[Term] +id: GO:0110127 +name: phloem unloading +namespace: biological_process +def: "The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:19025382] +is_a: GO:0010233 ! phloem transport + +[Term] +id: GO:0110128 +name: phloem sucrose unloading +namespace: biological_process +def: "The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues." [GOC:lr, PMID:30018170] +is_a: GO:0015770 ! sucrose transport +is_a: GO:0110127 ! phloem unloading + +[Term] +id: GO:0110129 +name: SHREC2 complex +namespace: cellular_component +def: "A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2." [GOC:mah, PMID:19111658] +is_a: GO:0000118 ! histone deacetylase complex +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:0110130 +name: ribitol-5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate." [GOC:rn, PMID:30240188] +xref: RHEA:47648 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:0110131 +name: Aim21-Tda2 complex +namespace: cellular_component +def: "A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables." [GOC:rn, PMID:28706108, PMID:29467252] +synonym: "Aim21/Tda2 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030479 ! actin cortical patch + +[Term] +id: GO:0110132 +name: obsolete regulation of CRISPR-cas system +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308] +comment: This term was obsoleted because it does not accurately capture the process described in the literature. +is_obsolete: true + +[Term] +id: GO:0110133 +name: obsolete negative regulation of CRISPR-cas system +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of a CRISPR-cas system." [PMID:30190307, PMID:30190308] +comment: This term was obsoleted because it does not accurately capture the process described in the literature. +is_obsolete: true +consider: GO:0098672 + +[Term] +id: GO:0110134 +name: meiotic drive +namespace: biological_process +def: "A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis." [GOC:mah, PMID:26920473, PMID:29322557, PMID:29499907] +subset: goslim_pombe +is_a: GO:0022414 ! reproductive process + +[Term] +id: GO:0110135 +name: Norrin signaling pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state." [GOC:BHF, GOC:rl, PMID:15035989, PMID:17955262] +is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling + +[Term] +id: GO:0110136 +name: protein-RNA complex remodeling +namespace: biological_process +def: "The acquisition, loss, or modification of macromolecules within a protein-RNA complex, resulting in the alteration of an existing complex." [GOC:rn, PMID:19737519, PMID:20542003, PMID:24240281] +is_a: GO:0034367 ! protein-containing complex remodeling +is_a: GO:0071826 ! ribonucleoprotein complex subunit organization + +[Term] +id: GO:0110137 +name: regulation of imaginal disc-derived leg joint morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized." [GOC:ha, PMID:25329825] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0007480 ! imaginal disc-derived leg morphogenesis + +[Term] +id: GO:0110138 +name: positive regulation of imaginal disc-derived leg joint morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis +relationship: positively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis + +[Term] +id: GO:0110139 +name: negative regulation of imaginal disc-derived leg joint morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis." [GOC:ha, PMID:25329825] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0110137 ! regulation of imaginal disc-derived leg joint morphogenesis +relationship: negatively_regulates GO:0007480 ! imaginal disc-derived leg morphogenesis + +[Term] +id: GO:0110140 +name: flagellum attachment zone organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum attachment zone. FAZ is a network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [GOC:ach, PMID:26776656] +synonym: "FAZ organization" EXACT [] +synonym: "flagellum attachment zone organisation" EXACT [] +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0110141 +name: L-glutamate import into mitochondrion +namespace: biological_process +def: "The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix." [GOC:vw, PMID:30297026] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0051938 ! L-glutamate import +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0110142 +name: ubiquinone biosynthesis complex +namespace: cellular_component +def: "The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K." [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758] +synonym: "CoQ metabolon" EXACT [PMID:28927698] +synonym: "Ubi complex" EXACT [PMID:30686758] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0110143 +name: magnetosome +namespace: cellular_component +def: "A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles." [GOC:aa, PMID:27620945] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0110144 +name: obsolete magnetosome part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a magnetosome, a membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria." [GOC:aa, PMID:27620945] +is_obsolete: true +consider: GO:0110143 + +[Term] +id: GO:0110145 +name: magnetosome lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a magnetosome." [GOC:aa, PMID:27620945] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0110143 ! magnetosome + +[Term] +id: GO:0110146 +name: magnetosome membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a magnetosome." [GOC:aa, PMID:27620945] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0110143 ! magnetosome + +[Term] +id: GO:0110147 +name: protein maturation by nickel ion transfer +namespace: biological_process +def: "A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation." [GOC:al, PMID:24115911] +is_a: GO:0051604 ! protein maturation + +[Term] +id: GO:0110148 +name: biomineralization +namespace: biological_process +def: "The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products." [GOC:aa, PMID:24395694, PMID:28229486] +synonym: "biomineral formation" NARROW [] +synonym: "biomineralisation" EXACT [] +synonym: "mineralisation" EXACT [] +synonym: "mineralization" EXACT [] +xref: Wikipedia:Biomineralization +is_a: GO:0008150 ! biological_process + +[Term] +id: GO:0110149 +name: regulation of biomineralization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] +synonym: "regulation of biomineral formation" NARROW [] +synonym: "regulation of biomineralisation" EXACT [] +synonym: "regulation of mineralisation" EXACT [] +synonym: "regulation of mineralization" EXACT [] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0110148 ! biomineralization + +[Term] +id: GO:0110150 +name: negative regulation of biomineralization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] +synonym: "negative regulation of biomineral formation" NARROW [] +synonym: "negative regulation of biomineralisation" EXACT [] +synonym: "negative regulation of mineralisation" EXACT [] +synonym: "negative regulation of mineralization" EXACT [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0110149 ! regulation of biomineralization +relationship: negatively_regulates GO:0110148 ! biomineralization + +[Term] +id: GO:0110151 +name: positive regulation of biomineralization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms." [PMID:22992051] +synonym: "positive regulation of biomineral formation" NARROW [] +synonym: "positive regulation of biomineralisation" EXACT [] +synonym: "positive regulation of mineralisation" EXACT [] +synonym: "positive regulation of mineralization" EXACT [] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0110149 ! regulation of biomineralization +relationship: positively_regulates GO:0110148 ! biomineralization + +[Term] +id: GO:0110152 +name: RNA NAD-cap (NAD-forming) hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+)." [GOC:sp, PMID:28283058, RHEA:60880] +comment: This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. +xref: RHEA:60880 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0110153 +name: RNA NAD-cap (NMN-forming) hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)." [GOC:sp, PMID:25533955, PMID:31101919, RHEA:60876] +comment: This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. +xref: RHEA:60876 +is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0110154 +name: RNA decapping +namespace: biological_process +def: "Cleavage of the 5'-cap of an RNA." [GOC:sp, PMID:25533955, PMID:31101919] +is_a: GO:0016070 ! RNA metabolic process + +[Term] +id: GO:0110155 +name: NAD-cap decapping +namespace: biological_process +def: "Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes." [GOC:sp, PMID:25533955, PMID:28283058, PMID:31101919] +is_a: GO:0110154 ! RNA decapping + +[Term] +id: GO:0110156 +name: methylguanosine-cap decapping +namespace: biological_process +def: "Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA." [PMID:23287066] +is_a: GO:0110154 ! RNA decapping + +[Term] +id: GO:0110157 +name: reelin complex +namespace: cellular_component +def: "An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain." [GOC:bhm, PMID:21844191, PMID:28887403] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005615 ! extracellular space + +[Term] +id: GO:0110158 +name: calpain complex +namespace: cellular_component +def: "A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate." [GOC:bhm, PMID:10639123] +synonym: "M-calpain" NARROW [] +synonym: "mu-calpain" NARROW [] +is_a: GO:0008303 ! caspase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0110159 +name: regulation of mitotic spindle formation (spindle phase one) +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw, PMID:27697865] +is_a: GO:1901673 ! regulation of mitotic spindle assembly +relationship: part_of GO:0032888 ! regulation of mitotic spindle elongation +relationship: regulates GO:0061804 ! mitotic spindle formation (spindle phase one) + +[Term] +id: GO:0110160 +name: negative regulation of mitotic spindle formation (spindle phase one) +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw] +is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) +is_a: GO:1905831 ! negative regulation of spindle assembly +relationship: negatively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) + +[Term] +id: GO:0110161 +name: positive regulation of mitotic spindle formation (spindle phase one) +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one)." [GOC:vw] +is_a: GO:0110028 ! positive regulation of mitotic spindle organization +is_a: GO:0110159 ! regulation of mitotic spindle formation (spindle phase one) +is_a: GO:1905832 ! positive regulation of spindle assembly +relationship: positively_regulates GO:0061804 ! mitotic spindle formation (spindle phase one) + +[Term] +id: GO:0110162 +name: regulation of mitotic spindle elongation (spindle phase three) +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] +is_a: GO:0032888 ! regulation of mitotic spindle elongation +is_a: GO:0060236 ! regulation of mitotic spindle organization +relationship: regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) + +[Term] +id: GO:0110163 +name: negative regulation of mitotic spindle elongation (spindle phase three) +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) +is_a: GO:1902845 ! negative regulation of mitotic spindle elongation +relationship: negatively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) + +[Term] +id: GO:0110164 +name: positive regulation of mitotic spindle elongation (spindle phase three) +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three)." [GOC:vw, PMID:27697865] +is_a: GO:0110028 ! positive regulation of mitotic spindle organization +is_a: GO:0110162 ! regulation of mitotic spindle elongation (spindle phase three) +is_a: GO:1902846 ! positive regulation of mitotic spindle elongation +relationship: positively_regulates GO:0061805 ! mitotic spindle elongation (spindle phase three) + +[Term] +id: GO:0110165 +name: cellular anatomical entity +namespace: cellular_component +def: "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex." [GOC:kmv] +is_a: GO:0005575 ! cellular_component + +[Term] +id: GO:0110166 +name: DNA synthesis involved in mitochondrial DNA replication +namespace: biological_process +def: "Any DNA biosynthetic process that is involved in mitochondrial DNA replication." [PMID:28408491, PMID:29931097] +synonym: "DNA biosynthetic process involved in mitochondrial DNA replication" EXACT [] +is_a: GO:0032042 ! mitochondrial DNA metabolic process +is_a: GO:0090592 ! DNA synthesis involved in DNA replication +relationship: part_of GO:0006264 ! mitochondrial DNA replication + +[Term] +id: GO:0120001 +name: apical plasma membrane urothelial plaque +namespace: cellular_component +def: "A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array." [GOC:krc, PMID:21468280, PMID:21887288] +synonym: "asymmetric unit membrane" EXACT [] +synonym: "AUM" RELATED [] +is_a: GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0120002 +name: fusiform vesicle +namespace: cellular_component +def: "A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder." [GOC:krc, PMID:21468280, PMID:21887288] +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:0120003 +name: hinge region between urothelial plaques of apical plasma membrane +namespace: cellular_component +def: "A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane." [GOC:krc, PMID:21468280, PMID:21887288] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0016324 ! apical plasma membrane + +[Term] +id: GO:0120006 +name: regulation of glutamatergic neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:1905962 ! glutamatergic neuron differentiation + +[Term] +id: GO:0120007 +name: negative regulation of glutamatergic neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation +relationship: negatively_regulates GO:1905962 ! glutamatergic neuron differentiation + +[Term] +id: GO:0120008 +name: positive regulation of glutamatergic neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation." [PMID:24030726] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:0120006 ! regulation of glutamatergic neuron differentiation +relationship: positively_regulates GO:1905962 ! glutamatergic neuron differentiation + +[Term] +id: GO:0120009 +name: intermembrane lipid transfer +namespace: biological_process +def: "The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +is_a: GO:0006869 ! lipid transport +is_a: GO:0061024 ! membrane organization + +[Term] +id: GO:0120010 +name: intermembrane phospholipid transfer +namespace: biological_process +def: "The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +is_a: GO:0015914 ! phospholipid transport +is_a: GO:0120009 ! intermembrane lipid transfer + +[Term] +id: GO:0120011 +name: intermembrane sterol transfer +namespace: biological_process +def: "The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +is_a: GO:0015918 ! sterol transport +is_a: GO:0120009 ! intermembrane lipid transfer + +[Term] +id: GO:0120012 +name: intermembrane sphingolipid transfer +namespace: biological_process +def: "The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs)." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0120009 ! intermembrane lipid transfer + +[Term] +id: GO:0120013 +name: lipid transfer activity +namespace: molecular_function +def: "Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane lipid transfer activity" EXACT [] +synonym: "lipid carrier activity" EXACT [] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0120014 +name: phospholipid transfer activity +namespace: molecular_function +def: "Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane phospholipid transfer activity" NARROW [] +synonym: "phospholipid carrier activity" EXACT [] +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0120015 +name: sterol transfer activity +namespace: molecular_function +def: "Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane sterol transfer activity" NARROW [] +synonym: "sterol carrier activity" EXACT [] +is_a: GO:0015248 ! sterol transporter activity +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0120016 +name: sphingolipid transfer activity +namespace: molecular_function +def: "Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane sphingolipid transfer activity" NARROW [] +synonym: "sphingolipid carrier activity" NARROW [] +is_a: GO:0046624 ! sphingolipid transporter activity +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0120017 +name: ceramide transfer activity +namespace: molecular_function +alt_id: GO:0035620 +def: "Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "ceramide carrier activity" EXACT [] +synonym: "ceramide transporter activity" BROAD [] +synonym: "intermembrane ceramide transfer activity" NARROW [] +is_a: GO:0120016 ! sphingolipid transfer activity + +[Term] +id: GO:0120019 +name: phosphatidylcholine transfer activity +namespace: molecular_function +def: "Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane phosphatidylcholine transfer activity" NARROW [] +synonym: "phosphatidylcholine carrier activity" EXACT [] +is_a: GO:0008525 ! phosphatidylcholine transporter activity +is_a: GO:0120014 ! phospholipid transfer activity + +[Term] +id: GO:0120020 +name: cholesterol transfer activity +namespace: molecular_function +alt_id: GO:0017127 +def: "Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "cholesterol carrier activity" EXACT [] +synonym: "cholesterol transporter activity" BROAD [] +synonym: "intermembrane cholesterol transfer activity" NARROW [] +xref: Reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux" +xref: Reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane" +xref: Reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake" +xref: Reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake" +xref: Reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface" +xref: Reactome:R-HSA-5682111 "Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane" +xref: Reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane" +is_a: GO:0120015 ! sterol transfer activity + +[Term] +id: GO:0120021 +name: oxysterol transfer activity +namespace: molecular_function +def: "Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198] +synonym: "intermembrane oxysterol transfer activity" NARROW [] +synonym: "oxysterol carrier activity" EXACT [] +is_a: GO:0120015 ! sterol transfer activity + +[Term] +id: GO:0120022 +name: glucagon family peptide binding +namespace: molecular_function +alt_id: GO:0120024 +def: "Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP)." [PMID:17715056] +synonym: "glucagon binding" NARROW [] +synonym: "glucagon-like peptide binding" NARROW [] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0120023 +name: somatostatin binding +namespace: molecular_function +def: "Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin." [GOC:cvs, PMID:20472043] +is_a: GO:0017046 ! peptide hormone binding + +[Term] +id: GO:0120025 +name: plasma membrane bounded cell projection +namespace: cellular_component +def: "A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] +is_a: GO:0042995 ! cell projection + +[Term] +id: GO:0120026 +name: host cell uropod +namespace: cellular_component +def: "A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [PMID:24965475] +synonym: "host cell uropodium" EXACT [] +is_a: GO:0044157 ! host cell projection + +[Term] +id: GO:0120027 +name: regulation of osmosensory signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw] +is_a: GO:0106049 ! regulation of cellular response to osmotic stress +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0120028 +name: negative regulation of osmosensory signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling pathway." [GOC:vw] +is_a: GO:0120027 ! regulation of osmosensory signaling pathway +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0007231 ! osmosensory signaling pathway + +[Term] +id: GO:0120029 +name: proton export across plasma membrane +namespace: biological_process +def: "The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:9762918] +synonym: "hydrogen ion export across plasma membrane" EXACT [] +synonym: "hydrogen ion export from cell" BROAD [] +synonym: "proton export from cell" BROAD [] +is_a: GO:0140115 ! export across plasma membrane +is_a: GO:1902600 ! proton transmembrane transport + +[Term] +id: GO:0120030 +name: positive regulation of cilium beat frequency involved in ciliary motility +namespace: biological_process +def: "Any process that activates or increases the frequency of cilium beating involved in ciliary motility." [PMID:28035044] +is_a: GO:0060296 ! regulation of cilium beat frequency involved in ciliary motility + +[Term] +id: GO:0120031 +name: plasma membrane bounded cell projection assembly +namespace: biological_process +def: "Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon." [GOC:krc] +synonym: "eupodium" NARROW [GOC:krc, GOC:rjd, PMID:10328951, PMID:9096956] +is_a: GO:0030031 ! cell projection assembly +is_a: GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0120032 +name: regulation of plasma membrane bounded cell projection assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly." [GOC:krc] +is_a: GO:0060491 ! regulation of cell projection assembly +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: regulates GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0120033 +name: negative regulation of plasma membrane bounded cell projection assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: negatively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0120034 +name: positive regulation of plasma membrane bounded cell projection assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly." [GOC:krc] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: positively_regulates GO:0120031 ! plasma membrane bounded cell projection assembly + +[Term] +id: GO:0120035 +name: regulation of plasma membrane bounded cell projection organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections." [GOC:krc] +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0120036 ! plasma membrane bounded cell projection organization + +[Term] +id: GO:0120036 +name: plasma membrane bounded cell projection organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] +is_a: GO:0030030 ! cell projection organization + +[Term] +id: GO:0120038 +name: obsolete plasma membrane bounded cell projection part +namespace: cellular_component +def: "OBSOLETE. Any constituent part of a plasma membrane bounded cell projection, a prolongation or process extending from a cell, e.g. a cilium or axon." [GOC:krc] +is_obsolete: true +consider: GO:0120025 + +[Term] +id: GO:0120039 +name: plasma membrane bounded cell projection morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized." [GOC:krc] +is_a: GO:0048858 ! cell projection morphogenesis + +[Term] +id: GO:0120040 +name: regulation of macrophage proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0070663 ! regulation of leukocyte proliferation +relationship: regulates GO:0061517 ! macrophage proliferation + +[Term] +id: GO:0120041 +name: positive regulation of macrophage proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0070665 ! positive regulation of leukocyte proliferation +is_a: GO:0120040 ! regulation of macrophage proliferation +relationship: positively_regulates GO:0061517 ! macrophage proliferation + +[Term] +id: GO:0120042 +name: negative regulation of macrophage proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0070664 ! negative regulation of leukocyte proliferation +is_a: GO:0120040 ! regulation of macrophage proliferation +relationship: negatively_regulates GO:0061517 ! macrophage proliferation + +[Term] +id: GO:0120043 +name: stereocilium shaft +namespace: cellular_component +def: "The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle." [GOC:krc, PMID:20170899] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0120044 +name: stereocilium base +namespace: cellular_component +def: "The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium." [GOC:krc, PMID:20170899] +synonym: "stereocilium taper" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0120045 +name: stereocilium maintenance +namespace: biological_process +def: "The organization process that preserves a stereocilium in a stable functional or structural state." [GOC:krc, PMID:27693694] +is_a: GO:0043954 ! cellular component maintenance +is_a: GO:0060122 ! inner ear receptor cell stereocilium organization + +[Term] +id: GO:0120046 +name: regulation of protein localization to medial cortical node +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789] +is_a: GO:0106011 ! regulation of protein localization to medial cortex +relationship: regulates GO:1902577 ! protein localization to medial cortical node + +[Term] +id: GO:0120047 +name: positive regulation of protein localization to medial cortical node +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node." [PMID:19474789] +is_a: GO:0106012 ! positive regulation of protein localization to medial cortex +is_a: GO:0120046 ! regulation of protein localization to medial cortical node +relationship: positively_regulates GO:1902577 ! protein localization to medial cortical node + +[Term] +id: GO:0120048 +name: U6 snRNA (adenine-(43)-N(6))-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA." [PMID:28525753] +is_a: GO:0106346 ! snRNA methyltransferase activity + +[Term] +id: GO:0120049 +name: snRNA (adenine-N6)-methylation +namespace: biological_process +def: "The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule." [PMID:28525753] +is_a: GO:0040031 ! snRNA modification + +[Term] +id: GO:0120053 +name: ribitol beta-1,4-xylosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R." [PMID:27733679] +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0120054 +name: intestinal motility +namespace: biological_process +def: "Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth)." [GOC:sl, PMID:15890336] +is_a: GO:0022600 ! digestive system process + +[Term] +id: GO:0120055 +name: small intestinal transit +namespace: biological_process +def: "Migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] +synonym: "small bowel transit" EXACT [] +synonym: "small intestine transit" EXACT [] +is_a: GO:0120054 ! intestinal motility + +[Term] +id: GO:0120056 +name: large intestinal transit +namespace: biological_process +def: "Migration of ingested material along the length of the large intestine." [GOC:sl, PMID:28157109] +synonym: "colon transit" EXACT [] +synonym: "colonic transit" EXACT [] +synonym: "large bowel transit" EXACT [] +synonym: "large intestine transit" EXACT [] +is_a: GO:0120054 ! intestinal motility + +[Term] +id: GO:0120057 +name: regulation of small intestinal transit +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] +synonym: "regulation of small bowel transit" EXACT [] +synonym: "regulation of small intestine transit" EXACT [] +is_a: GO:0044058 ! regulation of digestive system process +relationship: regulates GO:0120055 ! small intestinal transit + +[Term] +id: GO:0120058 +name: positive regulation of small intestinal transit +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] +synonym: "positive regulation of small bowel transit" EXACT [] +synonym: "positive regulation of small intestine transit" EXACT [] +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:0120057 ! regulation of small intestinal transit +relationship: positively_regulates GO:0120055 ! small intestinal transit + +[Term] +id: GO:0120059 +name: negative regulation of small intestinal transit +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of any small intestinal transit process, the migration of ingested material along the length of the small intestine." [GOC:sl, PMID:15890336] +synonym: "negative regulation of small bowel transit" EXACT [] +synonym: "negative regulation of small intestine transit" EXACT [] +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:0120057 ! regulation of small intestinal transit +relationship: negatively_regulates GO:0120055 ! small intestinal transit + +[Term] +id: GO:0120060 +name: regulation of gastric emptying +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] +synonym: "regulation of small bowel emptying" EXACT [] +synonym: "regulation of small intestine emptying" EXACT [] +is_a: GO:1905333 ! regulation of gastric motility +relationship: regulates GO:0035483 ! gastric emptying + +[Term] +id: GO:0120061 +name: negative regulation of gastric emptying +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:0120060 ! regulation of gastric emptying +relationship: negatively_regulates GO:0035483 ! gastric emptying + +[Term] +id: GO:0120062 +name: positive regulation of gastric emptying +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum." [GOC:sl, PMID:15890336] +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:0120060 ! regulation of gastric emptying +relationship: positively_regulates GO:0035483 ! gastric emptying + +[Term] +id: GO:0120063 +name: stomach smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach." [GOC:sl, PMID:15890336] +is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:0120064 +name: stomach pylorus smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach." [GOC:sl, PMID:15890336] +is_a: GO:0014828 ! distal stomach smooth muscle contraction + +[Term] +id: GO:0120065 +name: pyloric antrum smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach." [GOC:sl, PMID:15890336] +synonym: "antrum smooth muscle contraction" EXACT [] +is_a: GO:0120064 ! stomach pylorus smooth muscle contraction + +[Term] +id: GO:0120066 +name: pyloric canal smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter." [GOC:sl, PMID:15890336] +is_a: GO:0120064 ! stomach pylorus smooth muscle contraction + +[Term] +id: GO:0120067 +name: pyloric sphincter smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum." [GOC:sl, PMID:15890336] +is_a: GO:0120064 ! stomach pylorus smooth muscle contraction + +[Term] +id: GO:0120068 +name: regulation of stomach fundus smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: regulates GO:0014825 ! stomach fundus smooth muscle contraction + +[Term] +id: GO:0120069 +name: positive regulation of stomach fundus smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +relationship: positively_regulates GO:0014825 ! stomach fundus smooth muscle contraction + +[Term] +id: GO:0120070 +name: negative regulation of stomach fundus smooth muscle contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:0120068 ! regulation of stomach fundus smooth muscle contraction +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +relationship: negatively_regulates GO:0014825 ! stomach fundus smooth muscle contraction + +[Term] +id: GO:0120071 +name: regulation of pyloric antrum smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: regulates GO:0120065 ! pyloric antrum smooth muscle contraction + +[Term] +id: GO:0120072 +name: positive regulation of pyloric antrum smooth muscle contraction +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +relationship: positively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction + +[Term] +id: GO:0120073 +name: negative regulation of pyloric antrum smooth muscle contraction +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction." [GOC:sl, PMID:15890336] +is_a: GO:0120071 ! regulation of pyloric antrum smooth muscle contraction +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +relationship: negatively_regulates GO:0120065 ! pyloric antrum smooth muscle contraction + +[Term] +id: GO:0120074 +name: regulation of endocardial cushion cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: regulates GO:0061443 ! endocardial cushion cell differentiation + +[Term] +id: GO:0120075 +name: positive regulation of endocardial cushion cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation +is_a: GO:1905209 ! positive regulation of cardiocyte differentiation +relationship: positively_regulates GO:0061443 ! endocardial cushion cell differentiation + +[Term] +id: GO:0120076 +name: negative regulation of endocardial cushion cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0120074 ! regulation of endocardial cushion cell differentiation +is_a: GO:1905208 ! negative regulation of cardiocyte differentiation +relationship: negatively_regulates GO:0061443 ! endocardial cushion cell differentiation + +[Term] +id: GO:0120077 +name: angiogenic sprout fusion +namespace: biological_process +def: "The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis." [GOC:cvs, PMID:28264837] +synonym: "blood vessel anastomosis" EXACT [] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:0120078 +name: cell adhesion involved in sprouting angiogenesis +namespace: biological_process +def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network." [GOC:cvs, PMID:28264837] +synonym: "cell adhesion involved in blood vessel anastomosis" EXACT [] +synonym: "cell adhesion involved in vascular anastomosis" RELATED [] +is_a: GO:0007155 ! cell adhesion +relationship: part_of GO:0120077 ! angiogenic sprout fusion + +[Term] +id: GO:0120079 +name: obsolete regulation of microfilament motor activity +namespace: biological_process +alt_id: GO:1904621 +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of actin filament motor activity" EXACT [] +synonym: "regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie] +synonym: "regulation of actin-dependent ATPase activity" RELATED [] +synonym: "regulation of actin-filament motor activity" EXACT [] +synonym: "regulation of muscle motor activity" NARROW [] +synonym: "regulation of myosin ATPase activity" RELATED [] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:0120080 +name: obsolete negative regulation of microfilament motor activity +namespace: biological_process +alt_id: GO:1904622 +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of actin-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of actin-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of actin-dependent ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of actin filament motor activity" EXACT [] +synonym: "negative regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of actin-dependent ATPase activity" RELATED [] +synonym: "negative regulation of actin-filament motor activity" EXACT [] +synonym: "negative regulation of muscle motor activity" NARROW [] +synonym: "negative regulation of myosin ATPase activity" RELATED [] +is_obsolete: true +consider: GO:0140661 + +[Term] +id: GO:0120081 +name: obsolete positive regulation of microfilament motor activity +namespace: biological_process +alt_id: GO:1904623 +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of microfilament motor activity." [GOC:mah, PMID:20705471, PMID:8621557] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of actin-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of actin-dependent ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of actin filament motor activity" EXACT [] +synonym: "positive regulation of actin-activated ATPase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of actin-dependent ATPase activity" RELATED [] +synonym: "positive regulation of actin-filament motor activity" EXACT [] +synonym: "positive regulation of muscle motor activity" NARROW [] +synonym: "positive regulation of myosin ATPase activity" BROAD [] +synonym: "upregulation of actin-dependent ATPase activity" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:0140660 + +[Term] +id: GO:0120082 +name: smooth endoplasmic reticulum cisterna +namespace: cellular_component +def: "A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005790 ! smooth endoplasmic reticulum +relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network + +[Term] +id: GO:0120083 +name: rough endoplasmic reticulum cisterna +namespace: cellular_component +def: "A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity." [GOC:sl, PMID:12112448] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0071781 ! endoplasmic reticulum cisternal network + +[Term] +id: GO:0120084 +name: endothelial tip cell filopodium assembly +namespace: biological_process +def: "The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout." [GOC:cvs, PMID:28264837] +is_a: GO:0046847 ! filopodium assembly + +[Term] +id: GO:0120085 +name: transposon integration involved in RNA-mediated transposition +namespace: biological_process +def: "Any transposon integration that contributes to a process of RNA-mediated transposition." [GOC:mah, PMID:26358720] +synonym: "retrotransposon integration" EXACT [] +is_a: GO:0070893 ! transposon integration +relationship: part_of GO:0032197 ! transposition, RNA-mediated + +[Term] +id: GO:0120086 +name: (3S)-(+)-asterisca-2(9),6-diene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene." [PMID:27862766] +synonym: "asterisca-2(9),6-diene synthase activity" BROAD [] +is_a: GO:0010334 ! sesquiterpene synthase activity + +[Term] +id: GO:0120091 +name: jasmonic acid hydrolase +namespace: molecular_function +def: "Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid." [PMID:28559313, PMID:28760569] +synonym: "2-oxoglutarate dioxygenase" BROAD [] +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:0120092 +name: crotonyl-CoA hydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine." [PMID:28803779] +xref: RHEA:45584 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:0120093 +name: regulation of peptidyl-lysine crotonylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of crotonylation of a lysine residue in a protein." [PMID:28803779] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0140066 ! peptidyl-lysine crotonylation + +[Term] +id: GO:0120094 +name: negative regulation of peptidyl-lysine crotonylation +namespace: biological_process +def: "Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein." [PMID:28803779] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0120093 ! regulation of peptidyl-lysine crotonylation +relationship: negatively_regulates GO:0140066 ! peptidyl-lysine crotonylation + +[Term] +id: GO:0120095 +name: vacuole-isolation membrane contact site +namespace: cellular_component +def: "An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome." [PMID:23549786] +synonym: "vacuole-IM contact site" EXACT [] +synonym: "vacuole-phagophore contact site" EXACT [] +synonym: "VICS" RELATED [] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0120097 +name: glycosylphosphatidylinositol-mannosyltransferase II complex +namespace: cellular_component +def: "A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p." [GOC:bhm, PMID:17615295] +synonym: "GPI-MT-I complex" RELATED [] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0120098 +name: procentriole +namespace: cellular_component +def: "A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primative land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells." [GOC:bhm, GOC:krc, PMID:18620859, PMID:21289083, PMID:25047614] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0120099 +name: procentriole replication complex +namespace: cellular_component +def: "A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates." [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0120100 +name: bacterial-type flagellum motor +namespace: cellular_component +def: "A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009425 ! bacterial-type flagellum basal body + +[Term] +id: GO:0120101 +name: bacterial-type flagellum stator complex +namespace: cellular_component +def: "A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] +synonym: "bacterial-type flagellum motor force generator complex" EXACT [PMID:24697492] +synonym: "bacterial-type flagellum torque generator complex" EXACT [DOI:10.1002/9780470015902.a0000744.pub4] +is_a: GO:0005887 ! integral component of plasma membrane +relationship: part_of GO:0120100 ! bacterial-type flagellum motor + +[Term] +id: GO:0120102 +name: bacterial-type flagellum secretion apparatus +namespace: cellular_component +def: "A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament." [DOI:10.1002/9780470015902.a0000744.pub4, GOC:cilia, PMID:10572114, PMID:12624192, PMID:24697492, PMID:25251856] +synonym: "bacterial-type flagellum export apparatus" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0009425 ! bacterial-type flagellum basal body + +[Term] +id: GO:0120103 +name: centriolar subdistal appendage +namespace: cellular_component +def: "A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68." [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092] +synonym: "subdistal appendage of basal body" EXACT [GOC:krc] +synonym: "subdistal appendage of centriole" EXACT [GOC:krc] +synonym: "subdistal appendage of mother centriole" EXACT [GOC:krc] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0120104 +name: mitotic actomyosin contractile ring, proximal layer +namespace: cellular_component +def: "The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, proximal layer" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring + +[Term] +id: GO:0120105 +name: mitotic actomyosin contractile ring, intermediate layer +namespace: cellular_component +def: "The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, intermediate layer" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring + +[Term] +id: GO:0120106 +name: mitotic actomyosin contractile ring, distal actin filament layer +namespace: cellular_component +def: "The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to." [GOC:krc, GOC:vw, PMID:28914606] +synonym: "actomyosin contractile ring, distal actin filament layer" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0110085 ! mitotic actomyosin contractile ring + +[Term] +id: GO:0120107 +name: bacterial-type flagellum rotor complex +namespace: cellular_component +def: "The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation." [GOC:cilia, PMID:10572114, PMID:12624192, PMID:25251856] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0120100 ! bacterial-type flagellum motor + +[Term] +id: GO:0120108 +name: DNA-3'-diphospho-5'-guanosine diphosphatase +namespace: molecular_function +def: "Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP." [PMID:26007660, RHEA:52140] +synonym: "DNA-3'pp5'G guanylate hydrolase" EXACT [] +xref: EC:3.6.1.72 +xref: RHEA:52140 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0120109 +name: mitotic telomere clustering and tethering at nuclear periphery +namespace: biological_process +def: "The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle." [PMID:25778919] +is_a: GO:0034397 ! telomere localization + +[Term] +id: GO:0120110 +name: interphase mitotic telomere clustering +namespace: biological_process +def: "The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope." [PMID:25778919] +comment: It is likely that both intra chromosome telomere clustering and inter-chromosome occur because a single focus is sometimes observed, although this has yet to be proven. +synonym: "mitotic telomere clustering during interphase" EXACT [] +is_a: GO:0034397 ! telomere localization +relationship: part_of GO:0120109 ! mitotic telomere clustering and tethering at nuclear periphery + +[Term] +id: GO:0120111 +name: neuron projection cytoplasm +namespace: cellular_component +def: "All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection." [GOC:ha] +is_a: GO:0032838 ! plasma membrane bounded cell projection cytoplasm +relationship: part_of GO:0043005 ! neuron projection + +[Term] +id: GO:0120112 +name: UDP-glucose transmembrane transport into endoplasmic reticulum +namespace: biological_process +def: "The directed movement of UDP-glucose from cytosol to endoplasmic reticulum." [PMID:27587357] +is_a: GO:0015786 ! UDP-glucose transmembrane transport +is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport + +[Term] +id: GO:0120113 +name: cytoplasm to vacuole transport by the NVT pathway +namespace: biological_process +def: "A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe." [PMID:26365378] +synonym: "cytoplasm to vacuole targeting" BROAD [] +synonym: "cytoplasm-to-vacuole targeting" BROAD [] +synonym: "protein localization by the Nbr1-mediated vacuolar targeting pathway" EXACT [] +synonym: "protein localization by the NVT pathway" EXACT [] +is_a: GO:0006623 ! protein targeting to vacuole + +[Term] +id: GO:0120114 +name: Sm-like protein family complex +namespace: cellular_component +def: "A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles." [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0120115 +name: Lsm2-8 complex +namespace: cellular_component +def: "A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202] +is_a: GO:0120114 ! Sm-like protein family complex + +[Term] +id: GO:0120116 +name: glucagon processing +namespace: biological_process +def: "The formation of mature glucagon by proteolysis of the precursor proglucagon." [PMID:28719828] +is_a: GO:0016486 ! peptide hormone processing + +[Term] +id: GO:0120117 +name: T cell meandering migration +namespace: biological_process +def: "The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs)." [GOC:add, GOC:krc, PMID:25083865] +synonym: "lymph node surveillance" RELATED [] +synonym: "T cell meandering search" EXACT [] +is_a: GO:0072678 ! T cell migration + +[Term] +id: GO:0120118 +name: flagella connector +namespace: cellular_component +def: "A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum." [PMID:11641501, PMID:15075226, PMID:16954145, PMID:26820516] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. +is_a: GO:0030054 ! cell junction + +[Term] +id: GO:0120119 +name: flagellum attachment zone +namespace: cellular_component +def: "A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species." [PMID:10361731, PMID:16414276, PMID:17945531, PMID:20541452, PMID:25972344, PMID:2606941, PMID:26746239, PMID:26776656] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. +synonym: "FAZ" RELATED [] +is_a: GO:0070161 ! anchoring junction + +[Term] +id: GO:0120120 +name: bilobe structure +namespace: cellular_component +def: "A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone)." [PMID:22327007, PMID:22445359, PMID:26540076] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. +synonym: "kinetoplastid flagellar hook complex" EXACT [PMID:26540076] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0120121 +name: tripartite attachment complex +namespace: cellular_component +def: "A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body." [PMID:12802053, PMID:18059470, PMID:24821793, PMID:27168148] +synonym: "TAC" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:0120122 +name: prolactin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals." [PMID:11015620] +synonym: "prolactin metabolism" EXACT [] +is_a: GO:0034754 ! cellular hormone metabolic process + +[Term] +id: GO:0120123 +name: ubiquitin activating enzyme complex +namespace: cellular_component +def: "A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:lnp, PMID:9545234] +synonym: "E1 complex" EXACT [GOC:lnp] +synonym: "E1 ubiquitin-activating enzyme" RELATED [GOC:lnp] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0120124 +name: membrane fusion priming complex +namespace: cellular_component +def: "A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes." [GOC:lnp, PMID:9015301] +synonym: "GATE-16 complex" EXACT [] +synonym: "LMA1 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0120125 +name: PNGase complex +namespace: cellular_component +def: "A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [GOC:lnp, PMID:15964983, PMID:16249333] +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:0120126 +name: response to copper ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion." [GOC:sl, PMID:24024382] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0120127 +name: response to zinc ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion." [GOC:sl, PMID:24024381] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:0120132 +name: positive regulation of apoptotic process in bone marrow cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in the bone marrow." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:27908889] +synonym: "activation of apoptosis in bone marrow" NARROW [GOC:krc] +synonym: "positive regulation of apoptosis in bone marrow" NARROW [GO:krc] +synonym: "positive regulation of apoptotic process in bone marrow" EXACT [] +synonym: "positive regulation of bone marrow cell apoptosis" EXACT [GOC:krc] +synonym: "positive regulation of bone marrow cell programmed cell death by apoptosis" EXACT [GOC:krc] +synonym: "positive regulation of killing of bone marrow cells" EXACT [GOC:krc] +synonym: "positive regulation of programmed cell death of bone marrow cells by apoptosis" EXACT [GOC:krc] +synonym: "positive regulation of programmed cell death, bone marrow cells" EXACT [GOC:krc] +synonym: "up regulation of apoptosis in bone marrow" EXACT [GOC:krc] +synonym: "up-regulation of apoptosis in bone marrow" EXACT [GOC:krc] +synonym: "upregulation of apoptosis in bone marrow" EXACT [GOC:krc] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0071865 ! regulation of apoptotic process in bone marrow cell +relationship: positively_regulates GO:0071839 ! apoptotic process in bone marrow cell + +[Term] +id: GO:0120133 +name: negative regulation of actin cortical patch assembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches." [PMID:19962315] +synonym: "down regulation of actin cortical patch assembly" EXACT [] +synonym: "down-regulation of actin cortical patch assembly" EXACT [] +synonym: "downregulation of actin cortical patch assembly" EXACT [] +synonym: "inhibition of actin cortical patch assembly" NARROW [] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +relationship: negatively_regulates GO:0000147 ! actin cortical patch assembly + +[Term] +id: GO:0120134 +name: proximal portion of axoneme +namespace: cellular_component +def: "The portion of the axoneme that is close to the base of the cilium." [GOC:krc] +synonym: "proximal part of axoneme" EXACT [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0120135 +name: distal portion of axoneme +namespace: cellular_component +def: "The portion of the axoneme that is close to the tip of the cilium." [GOC:krc] +synonym: "distal part of axoneme" EXACT [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0120136 +name: dUMP kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + dUMP = ADP + dUDP." [PMID:3010881, RHEA:30655] +synonym: "ATP:dUMP phosphotransferase activity" EXACT [] +synonym: "deoxyuridine monophosphate kinase activity" EXACT [] +synonym: "dUMP-kinase activity" EXACT [] +xref: RHEA:30655 +is_a: GO:0009041 ! uridylate kinase activity + +[Term] +id: GO:0120137 +name: positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +namespace: biological_process +def: "Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity." [PMID:23407971] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0062002 ! regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity +is_a: GO:0062013 ! positive regulation of small molecule metabolic process + +[Term] +id: GO:0120138 +name: regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:0120139 +name: positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:0120138 ! regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity + +[Term] +id: GO:0120140 +name: negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." [PMID:17097615] +is_a: GO:0010923 ! negative regulation of phosphatase activity +is_a: GO:0120138 ! regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity + +[Term] +id: GO:0120141 +name: regulation of ecdysone receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:1905957 ! regulation of cellular response to alcohol +relationship: regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway + +[Term] +id: GO:0120142 +name: positive regulation of ecdysone receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] +is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:0120141 ! regulation of ecdysone receptor-mediated signaling pathway +relationship: positively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway + +[Term] +id: GO:0120143 +name: negative regulation of ecdysone receptor-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway." [GOC:ha, PMID:23072462] +is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:0120141 ! regulation of ecdysone receptor-mediated signaling pathway +is_a: GO:1905958 ! negative regulation of cellular response to alcohol +relationship: negatively_regulates GO:0035076 ! ecdysone receptor-mediated signaling pathway + +[Term] +id: GO:0120145 +name: protein localization to basal ectoplasmic specialization +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a basal ectoplasmic specialization." [PMID:22872576] +synonym: "protein localisation in basal ectoplasmic specialization" EXACT [GOC:krc] +synonym: "protein localisation to basal ectoplasmic specialization" EXACT [GOC:krc] +synonym: "protein localization in basal ectoplasmic specialization" EXACT [GOC:krc] +is_a: GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0120146 +name: sulfatide binding +namespace: molecular_function +def: "Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group." [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide] +synonym: "3-O-sulfogalactosylceramide binding" EXACT [] +synonym: "SM4 binding" EXACT [] +synonym: "sulfated galactocerebroside binding" EXACT [] +is_a: GO:0051861 ! glycolipid binding + +[Term] +id: GO:0120147 +name: Formylglycine-generating oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O." [EC:1.8.3.7, RHEA:51152] +xref: EC:1.8.3.7 +xref: MetaCyc:RXN-16226 +xref: RHEA:51152 +is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor + +[Term] +id: GO:0120148 +name: host cell centrosome +namespace: cellular_component +def: "A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [ISBN:0198547684] +synonym: "host centrosome" EXACT [] +is_a: GO:0044163 ! host cytoskeleton + +[Term] +id: GO:0120149 +name: host cell peroxisome +namespace: cellular_component +def: "A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [PMID:9302272] +synonym: "host peroxisome" EXACT [] +is_a: GO:0033648 ! host intracellular membrane-bounded organelle +is_a: GO:0033655 ! host cell cytoplasm part + +[Term] +id: GO:0120150 +name: regulation of mitotic actomyosin contractile ring disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423] +synonym: "regulation of mitotic actomyosin ring disassembly" EXACT [PMID:19109423] +synonym: "regulation of mitotic CAR disassembly" EXACT [PMID:19109423] +synonym: "regulation of mitotic constriction ring disassembly" EXACT [PMID:19109423] +synonym: "regulation of mitotic contractile actomyosin ring disassembly" EXACT [PMID:19109423] +synonym: "regulation of mitotic cytokinetic ring disassembly" EXACT [PMID:19109423] +is_a: GO:0110020 ! regulation of actomyosin structure organization +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly + +[Term] +id: GO:0120151 +name: positive regulation of mitotic actomyosin contractile ring disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring disassembly." [PMID:19109423] +synonym: "positive regulation of mitotic actomyosin ring disassembly" EXACT [PMID:19109423] +synonym: "positive regulation of mitotic CAR disassembly" EXACT [PMID:19109423] +synonym: "positive regulation of mitotic constriction ring disassembly" EXACT [PMID:19109423] +synonym: "positive regulation of mitotic contractile actomyosin ring disassembly" EXACT [PMID:19109423] +synonym: "positive regulation of mitotic cytokinetic ring disassembly" EXACT [PMID:19109423] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0120150 ! regulation of mitotic actomyosin contractile ring disassembly +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +relationship: positively_regulates GO:1990274 ! mitotic actomyosin contractile ring disassembly + +[Term] +id: GO:0120152 +name: calcium-dependent outer dynein arm binding +namespace: molecular_function +def: "Binding to an outer dynein arm in the presence of calcium." [GOC:krc, PMID:18620543] +is_a: GO:0048306 ! calcium-dependent protein binding + +[Term] +id: GO:0120153 +name: calcium-dependent carbohydrate binding +namespace: molecular_function +def: "Binding to a carbohydrate in the presence of calcium." [PMID:25912189] +is_a: GO:0030246 ! carbohydrate binding + +[Term] +id: GO:0120154 +name: negative regulation of ERBB4 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway." [PMID:15219672] +is_a: GO:1901185 ! negative regulation of ERBB signaling pathway +relationship: negatively_regulates GO:0038130 ! ERBB4 signaling pathway + +[Term] +id: GO:0120155 +name: MIH complex +namespace: cellular_component +def: "A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins." [GOC:rn, PMID:24413167, PMID:24895401] +synonym: "Mlc1p-Iqg1p-Hof1p complex" EXACT [GOC:rn] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005935 ! cellular bud neck + +[Term] +id: GO:0120157 +name: PAR polarity complex +namespace: cellular_component +def: "A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC." [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236] +comment: "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4. +synonym: "apical polarity complex" EXACT [GOC:lnp] +synonym: "BEM1-CDC24-CLA4 complex" NARROW [] +synonym: "Cdc42p GEF-PAK complex" NARROW [] +synonym: "PAR3-PAR6-atypical PKC" NARROW [GOC:lnp] +synonym: "PAR3/PAR6/aPKC" NARROW [GOC:lnp] +synonym: "PAR6-PAR3-aPKC complex" NARROW [PMID:18005931] +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:0120158 +name: positive regulation of collagen catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:dph, GOC:tb] +synonym: "activation of collagen catabolic process" NARROW [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] +synonym: "positive regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] +synonym: "up regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "up-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +synonym: "upregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010710 ! regulation of collagen catabolic process +is_a: GO:0010714 ! positive regulation of collagen metabolic process +relationship: positively_regulates GO:0030574 ! collagen catabolic process + +[Term] +id: GO:0120159 +name: rRNA pseudouridine synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [PMID:28432181] +synonym: "16S rRNA pseudouridine(516) synthase" NARROW [EC:5.4.99.19] +synonym: "21S rRNA pseudouridine(2819) synthase" NARROW [EC:5.4.99.43] +synonym: "23S rRNA pseudouridine(1911/1915/1917) synthase" NARROW [EC:5.4.99.23] +synonym: "23S rRNA pseudouridine(2457) synthase" NARROW [EC:5.4.99.20] +synonym: "23S rRNA pseudouridine(2604) synthase" NARROW [EC:5.4.99.21] +synonym: "23S rRNA pseudouridine(2605) synthase" NARROW [EC:5.4.99.22] +synonym: "23S rRNA pseudouridine(746) synthase" NARROW [EC:5.4.99.29] +synonym: "23S rRNA pseudouridine(955/2504/2580) synthase" NARROW [EC:5.4.99.24] +xref: EC:5.4.99.19 +xref: EC:5.4.99.20 +xref: EC:5.4.99.21 +xref: EC:5.4.99.22 +xref: EC:5.4.99.23 +xref: EC:5.4.99.24 +xref: EC:5.4.99.29 +xref: EC:5.4.99.43 +is_a: GO:0009982 ! pseudouridine synthase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0120160 +name: intraciliary transport particle A binding +namespace: molecular_function +def: "Binding to an intraciliary transport particle A (IFT A) complex." [PMID:20889716] +synonym: "IFT A complex binding" RELATED [] +synonym: "intraciliary transport complex A binding" EXACT [] +synonym: "intraflagellar transport complex A binding" EXACT [] +synonym: "intraflagellar transport particle A binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0120161 +name: regulation of cold-induced thermogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809] +synonym: "regulation of CIT" RELATED [] +is_a: GO:0019222 ! regulation of metabolic process +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0106106 ! cold-induced thermogenesis + +[Term] +id: GO:0120162 +name: positive regulation of cold-induced thermogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis." [PMID:27876809] +synonym: "positive regulation of CIT" RELATED [] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0120161 ! regulation of cold-induced thermogenesis +relationship: positively_regulates GO:0106106 ! cold-induced thermogenesis + +[Term] +id: GO:0120163 +name: negative regulation of cold-induced thermogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis." [PMID:27876809] +synonym: "negative regulation of CIT" RELATED [] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0120161 ! regulation of cold-induced thermogenesis +relationship: negatively_regulates GO:0106106 ! cold-induced thermogenesis + +[Term] +id: GO:0120164 +name: conidium germination +namespace: biological_process +def: "The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination." [DOI:10.1128/9781555815523.ch10, PMID:10835388, PMID:11377860, PMID:17950638, PMID:18944978, PMID:25063657, PMID:27355215, PMID:9529886] +is_a: GO:0009847 ! spore germination + +[Term] +id: GO:0120165 +name: perithecium development +namespace: biological_process +def: "The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:19547974, PMID:20739093, PMID:25311923] +is_a: GO:0030582 ! reproductive fruiting body development + +[Term] +id: GO:0120166 +name: protoperithecium formation +namespace: biological_process +def: "The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium." [DOI:10.1007/978-3-642-00286-1_2, PMID:125266, PMID:20739093, PMID:25311923, PMID:4410944, PMID:6235211, PMID:6235212] +comment: Note that this term represents protoperithecium formation across homothallic and heterothallic species that do not have the same mechanism. +is_a: GO:0030582 ! reproductive fruiting body development + +[Term] +id: GO:0120168 +name: detection of hot stimulus involved in thermoception +namespace: biological_process +def: "The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241] +synonym: "sensory detection of heat stimulus during thermoception" EXACT [] +synonym: "sensory detection of hot stimulus during thermoception" EXACT [] +synonym: "sensory transduction of heat stimulus during thermoception" EXACT [] +synonym: "sensory transduction of hot stimulus during thermoception" EXACT [] +synonym: "thermoception, sensory detection of heat stimulus" EXACT [] +synonym: "thermoception, sensory detection of hot stimulus" EXACT [] +synonym: "thermoception, sensory transduction of heat stimulus" EXACT [] +synonym: "thermoception, sensory transduction of hot stimulus" EXACT [] +is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception +relationship: part_of GO:0062036 ! sensory perception of hot stimulus + +[Term] +id: GO:0120169 +name: detection of cold stimulus involved in thermoception +namespace: biological_process +def: "The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception." [PMID:21335241] +synonym: "sensory detection of cold stimulus during thermoception" EXACT [] +synonym: "sensory transduction of cold stimulus during thermoception" EXACT [] +synonym: "thermoception, sensory detection of cold stimulus" EXACT [] +synonym: "thermoception, sensory transduction of cold stimulus" EXACT [] +is_a: GO:0050960 ! detection of temperature stimulus involved in thermoception +relationship: part_of GO:0062035 ! sensory perception of cold stimulus + +[Term] +id: GO:0120170 +name: intraciliary transport particle B binding +namespace: molecular_function +def: "Binding to an intraciliary transport particle B (IFT B) complex." [PMID:20889716] +synonym: "IFT B complex binding" RELATED [] +synonym: "intraciliary transport complex B binding" EXACT [] +synonym: "intraflagellar transport complex B binding" EXACT [] +synonym: "intraflagellar transport particle B binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0120171 +name: Cdc24p-Far1p-Gbetagamma complex +namespace: cellular_component +def: "A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit)." [PMID:10087263] +synonym: "CDC24-FAR1-BG complex" EXACT [GOC:bm] +synonym: "CDC24-FAR1-Gbetagamma complex" EXACT [GOC:bm] +synonym: "Cdc24p-Far1p-BG complex" EXACT [GOC:rn, PMID:10087263] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0120172 +name: positive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735] +is_a: GO:0120173 ! regulation of actin filament bundle convergence involved in mitotic contractile ring assembly +is_a: GO:1903482 ! positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +relationship: positively_regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly + +[Term] +id: GO:0120173 +name: regulation of actin filament bundle convergence involved in mitotic contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament bundle convergence involved in mitotic contractile ring assembly." [GOC:vw, PMID:24798735] +is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +relationship: regulates GO:1903478 ! actin filament bundle convergence involved in mitotic contractile ring assembly + +[Term] +id: GO:0120174 +name: stress-induced homeostatically regulated protein degradation pathway +namespace: biological_process +def: "A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway." [GOC:rl, GOC:rn, PMID:29861160] +comment: Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct. +synonym: "SHRED pathway" RELATED [GOC:rn] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0033554 ! cellular response to stress +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0120175 +name: regulation of torso signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0008293 ! torso signaling pathway + +[Term] +id: GO:0120176 +name: positive regulation of torso signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0120175 ! regulation of torso signaling pathway +relationship: positively_regulates GO:0008293 ! torso signaling pathway + +[Term] +id: GO:0120177 +name: negative regulation of torso signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway." [GOC:ha, PMID:23732470] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0120175 ! regulation of torso signaling pathway +relationship: negatively_regulates GO:0008293 ! torso signaling pathway + +[Term] +id: GO:0120178 +name: steroid hormone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [GOC:krc, GOC:nln] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042446 ! hormone biosynthetic process + +[Term] +id: GO:0120179 +name: adherens junction disassembly +namespace: biological_process +def: "The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GOC:aruk, GOC:bc, PMID:25490267] +is_a: GO:0034332 ! adherens junction organization +is_a: GO:0150147 ! cell-cell junction disassembly + +[Term] +id: GO:0120180 +name: cell-substrate junction disassembly +namespace: biological_process +def: "The disaggregation of a cell-substrate junction into its constituent components." [GOC:aruk, GOC:bc, PMID:25490267] +is_a: GO:0150115 ! cell-substrate junction organization +is_a: GO:0150146 ! cell junction disassembly + +[Term] +id: GO:0120181 +name: focal adhesion disassembly +namespace: biological_process +def: "The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity." [PMID:25490267] +is_a: GO:0120180 ! cell-substrate junction disassembly + +[Term] +id: GO:0120182 +name: regulation of focal adhesion disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267] +is_a: GO:0150116 ! regulation of cell-substrate junction organization +relationship: regulates GO:0120181 ! focal adhesion disassembly + +[Term] +id: GO:0120183 +name: positive regulation of focal adhesion disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components." [PMID:25490267] +is_a: GO:0120182 ! regulation of focal adhesion disassembly +is_a: GO:0150117 ! positive regulation of cell-substrate junction organization +relationship: positively_regulates GO:0120181 ! focal adhesion disassembly + +[Term] +id: GO:0120184 +name: negative regulation of focal adhesion disassembly +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components." [PMID:25490267] +is_a: GO:0120182 ! regulation of focal adhesion disassembly +is_a: GO:0150118 ! negative regulation of cell-substrate junction organization +relationship: negatively_regulates GO:0120181 ! focal adhesion disassembly + +[Term] +id: GO:0120185 +name: MBF transcription complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex." [PMID:9303312] +synonym: "DSC1 transcription factor complex assembly" EXACT [] +synonym: "MBF complex assembly" EXACT [] +synonym: "Mlu1-box binding factor assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0120186 +name: negative regulation of protein localization to chromatin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] +synonym: "negative regulation of protein localisation to chromatin" EXACT [GOC:krc] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905634 ! regulation of protein localization to chromatin +relationship: negatively_regulates GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:0120187 +name: positive regulation of protein localization to chromatin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromatin." [PMID:20889714, PMID:29899453] +synonym: "positive regulation of protein localisation to chromatin" EXACT [GOC:krc] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905634 ! regulation of protein localization to chromatin +relationship: positively_regulates GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:0120188 +name: regulation of bile acid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0032782 ! bile acid secretion + +[Term] +id: GO:0120189 +name: positive regulation of bile acid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0120188 ! regulation of bile acid secretion +is_a: GO:1903793 ! positive regulation of anion transport +relationship: positively_regulates GO:0032782 ! bile acid secretion + +[Term] +id: GO:0120190 +name: negative regulation of bile acid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0120188 ! regulation of bile acid secretion +is_a: GO:1903792 ! negative regulation of anion transport +relationship: negatively_regulates GO:0032782 ! bile acid secretion + +[Term] +id: GO:0120191 +name: negative regulation of termination of RNA polymerase II transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription." [GOC:krc, GOC:vw, PMID:29899453] +synonym: "down regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] +synonym: "down regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] +synonym: "down regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] +synonym: "down regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] +synonym: "down regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] +synonym: "down regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] +synonym: "down-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] +synonym: "down-regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] +synonym: "down-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] +synonym: "down-regulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] +synonym: "down-regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] +synonym: "down-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] +synonym: "downregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] +synonym: "downregulation of RNA polymerase II transcription termination" EXACT [GOC:krc] +synonym: "downregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] +synonym: "downregulation of termination of RNA polymerase II transcription" EXACT [GOC:krc] +synonym: "downregulation of transcription termination from Pol II promoter" EXACT [GOC:krc] +synonym: "downregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] +synonym: "negative regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:krc] +synonym: "negative regulation of RNA polymerase II transcription termination" EXACT [GOC:krc] +synonym: "negative regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] +synonym: "negative regulation of transcription termination from Pol II promoter" EXACT [GOC:krc] +synonym: "negative regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:krc] +synonym: "repression of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:krc] +synonym: "repression of RNA polymerase II transcription termination" NARROW [GOC:krc] +synonym: "repression of RNA polymerase II transcription termination factor activity" RELATED [GOC:krc] +synonym: "repression of termination of RNA polymerase II transcription" NARROW [GOC:krc] +synonym: "repression of transcription termination from Pol II promoter" NARROW [GOC:krc] +synonym: "repression of transcription termination from RNA polymerase II promoter" NARROW [GOC:krc] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination +is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription +relationship: negatively_regulates GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:0120192 +name: tight junction assembly +namespace: biological_process +def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:rl] +synonym: "occluding cell junction assembly" EXACT [GOC:rl] +synonym: "occluding junction assembly" EXACT [GOC:rl] +is_a: GO:0007043 ! cell-cell junction assembly +is_a: GO:0120193 ! tight junction organization + +[Term] +id: GO:0120193 +name: tight junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other." [GOC:krc, GOC:rl] +synonym: "occluding cell junction organization" EXACT [GOC:rl] +synonym: "occluding junction organization" EXACT [] +is_a: GO:0045216 ! cell-cell junction organization + +[Term] +id: GO:0120194 +name: regulation of anther dehiscence +namespace: biological_process +def: "Any process involved in the dehiscence of an anther to release the pollen grains contained within it." [GOC:lr, PMID:30911018] +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009901 ! anther dehiscence + +[Term] +id: GO:0120195 +name: positive regulation of anther dehiscence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anther dehiscence." [GOC:lr, PMID:30911018] +is_a: GO:0120194 ! regulation of anther dehiscence +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0009901 ! anther dehiscence + +[Term] +id: GO:0120196 +name: negative regulation of anther dehiscence +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence." [GOC:lr, PMID:30911018] +is_a: GO:0120194 ! regulation of anther dehiscence +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0009901 ! anther dehiscence + +[Term] +id: GO:0120197 +name: mucociliary clearance +namespace: biological_process +def: "The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways." [GOC:krc, PMID:24119105, PMID:27864314] +synonym: "MCC" RELATED [PMID:24119105, PMID:27864314] +synonym: "MCT" RELATED [PMID:28289722] +synonym: "mucociliary transport" EXACT [PMID:28289722] +is_a: GO:0003016 ! respiratory system process +is_a: GO:0003351 ! epithelial cilium movement involved in extracellular fluid movement + +[Term] +id: GO:0120198 +name: positive regulation of imaginal disc-derived wing size +namespace: biological_process +def: "Any process that increases the size of an imaginal disc-derived wing." [GOC:ha, PIMD:23485686] +is_a: GO:0044719 ! regulation of imaginal disc-derived wing size + +[Term] +id: GO:0120199 +name: cone photoreceptor outer segment +namespace: cellular_component +def: "The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0001750 ! photoreceptor outer segment + +[Term] +id: GO:0120200 +name: rod photoreceptor outer segment +namespace: cellular_component +def: "The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0001750 ! photoreceptor outer segment + +[Term] +id: GO:0120201 +name: cone photoreceptor disc membrane +namespace: cellular_component +def: "Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0060170 ! ciliary membrane +is_a: GO:0097381 ! photoreceptor disc membrane + +[Term] +id: GO:0120202 +name: rod photoreceptor disc membrane +namespace: cellular_component +def: "Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0030659 ! cytoplasmic vesicle membrane +is_a: GO:0097381 ! photoreceptor disc membrane + +[Term] +id: GO:0120203 +name: rod photoreceptor disc lumen +namespace: cellular_component +def: "The volume enclosed by the membrane of a rod photoreceptor cell disc membrane." [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304] +is_a: GO:0043233 ! organelle lumen +relationship: part_of GO:0120200 ! rod photoreceptor outer segment + +[Term] +id: GO:0120204 +name: methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2." [PMID:31043749] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0120205 +name: photoreceptor proximal connecting cilium +namespace: cellular_component +def: "The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR." [GOC:krc, PMID:29899041] +synonym: "PCC" RELATED [PMID:29899041] +synonym: "photoreceptor PCC" RELATED [PMID:29899041] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032391 ! photoreceptor connecting cilium + +[Term] +id: GO:0120206 +name: photoreceptor distal connecting cilium +namespace: cellular_component +def: "The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability." [GOC:krc, PMID:29899041] +synonym: "DCC" RELATED [PMID:29899041] +synonym: "photoreceptor DCC" RELATED [PMID:29899041] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0032391 ! photoreceptor connecting cilium + +[Term] +id: GO:0120207 +name: endocytosis, site selection +namespace: biological_process +def: "The process of selecting and or marking the position where endocytosis will occur." [GOC:vw, PMID:30044717] +is_a: GO:1990778 ! protein localization to cell periphery +relationship: part_of GO:0006897 ! endocytosis + +[Term] +id: GO:0120208 +name: telodendria +namespace: cellular_component +def: "Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons." [GOC:cvs, GOC:krc, PMID:11074451, PMID:11506430, PMID:14755521, PMID:1646866, PMID:20533354, PMID:29127712, PMID:451992, PMID:8390352] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:0120209 +name: cone telodendria +namespace: cellular_component +def: "Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:29127712] +is_a: GO:0120208 ! telodendria + +[Term] +id: GO:0120210 +name: rod telodendria +namespace: cellular_component +def: "Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina." [GOC:cvs, GOC:krc, PMID:14755521] +is_a: GO:0120208 ! telodendria + +[Term] +id: GO:0120211 +name: proacrosomal vesicle fusion +namespace: biological_process +def: "Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome." [GOC:krc, PMID:29991750] +is_a: GO:0006906 ! vesicle fusion +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0001675 ! acrosome assembly + +[Term] +id: GO:0120212 +name: sperm head-tail coupling apparatus +namespace: cellular_component +def: "A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head." [GOC:krc, PMID:24415959, PMID:30032984] +synonym: "head-tail coupling apparatus" EXACT [PMID:24415959, PMID:30032984] +synonym: "HTCA" RELATED [PMID:24415959] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0120213 +name: regulation of histidine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] +synonym: "regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "regulation of histidine formation" EXACT [GOC:krc] +synonym: "regulation of histidine synthesis" EXACT [GOC:krc] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0000105 ! histidine biosynthetic process + +[Term] +id: GO:0120214 +name: negative regulation of histidine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] +synonym: "down regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "down regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "down regulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "down regulation of histidine formation" EXACT [GOC:krc] +synonym: "down regulation of histidine synthesis" EXACT [GOC:krc] +synonym: "down-regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "down-regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "down-regulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "down-regulation of histidine formation" EXACT [GOC:krc] +synonym: "down-regulation of histidine synthesis" EXACT [GOC:krc] +synonym: "downregulation of histidine anabolism" EXACT [GOC:krc] +synonym: "downregulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "downregulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "downregulation of histidine formation" EXACT [GOC:krc] +synonym: "downregulation of histidine synthesis" EXACT [GOC:krc] +synonym: "inhibition of histidine anabolism" NARROW [GOC:krc] +synonym: "inhibition of histidine biosynthesis" NARROW [GOC:krc] +synonym: "inhibition of histidine biosynthetic process" NARROW [GOC:krc] +synonym: "inhibition of histidine formation" NARROW [GOC:krc] +synonym: "inhibition of histidine synthesis" NARROW [GOC:krc] +synonym: "negative regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "negative regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "negative regulation of histidine formation" EXACT [GOC:krc] +synonym: "negative regulation of histidine synthesis" EXACT [GOC:krc] +is_a: GO:0120213 ! regulation of histidine biosynthetic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0000105 ! histidine biosynthetic process + +[Term] +id: GO:0120215 +name: positive regulation of histidine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histidine biosynthetic process." [GOC:krc] +synonym: "activation of histidine anabolism" NARROW [GOC:krc] +synonym: "activation of histidine biosynthesis" NARROW [GOC:krc] +synonym: "activation of histidine biosynthetic process" NARROW [GOC:krc] +synonym: "activation of histidine formation" NARROW [GOC:krc] +synonym: "activation of histidine synthesis" NARROW [GOC:krc] +synonym: "positive regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "positive regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "positive regulation of histidine formation" EXACT [GOC:krc] +synonym: "positive regulation of histidine synthesis" EXACT [GOC:krc] +synonym: "up regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "up regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "up regulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "up regulation of histidine formation" EXACT [GOC:krc] +synonym: "up regulation of histidine synthesis" EXACT [GOC:krc] +synonym: "up-regulation of histidine anabolism" EXACT [GOC:krc] +synonym: "up-regulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "up-regulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "up-regulation of histidine formation" EXACT [GOC:krc] +synonym: "up-regulation of histidine synthesis" EXACT [GOC:krc] +synonym: "upregulation of histidine anabolism" EXACT [GOC:krc] +synonym: "upregulation of histidine biosynthesis" EXACT [GOC:krc] +synonym: "upregulation of histidine biosynthetic process" EXACT [GOC:krc] +synonym: "upregulation of histidine formation" EXACT [GOC:krc] +synonym: "upregulation of histidine synthesis" EXACT [GOC:krc] +is_a: GO:0120213 ! regulation of histidine biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:0000105 ! histidine biosynthetic process + +[Term] +id: GO:0120216 +name: matrilin complex +namespace: cellular_component +def: "A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer." [GOC:bhm, PMID:10367731, PMID:15075323, PMID:9699631] +synonym: "matrilin family complex" RELATED [GOC:bhm] +synonym: "matrilin-1 complex" NARROW [GOC:bhm] +synonym: "matrilin-2 complex" NARROW [GOC:bhm] +synonym: "matrilin-3 complex" NARROW [GOC:bhm] +synonym: "matrilin-4 complex" NARROW [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:0120217 +name: DNA gyrase complex +namespace: cellular_component +def: "A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB)." [GOC:bhm, GOC:krc, PMID:1657531, PMID:20675723, Wikipedia:DNA_gyrase] +synonym: "topoisomerase II complex" EXACT [GOC:bhm, GOC:krc, Wikipedia:DNA_gyrase] +is_a: GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex + +[Term] +id: GO:0120218 +name: host interaction involved in quorum sensing +namespace: biological_process +def: "A quorum sensing process that is modulated by some interaction with a host cell or organism." [GOC:krc, GOC:mlg, PMID:11780122, PMID:16630813] +is_a: GO:0009372 ! quorum sensing + +[Term] +id: GO:0120219 +name: subapical part of cell +namespace: cellular_component +def: "The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina." [GOC:krc, PMID:29891944] +synonym: "subapical region of cell" EXACT [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0120220 +name: basal body patch +namespace: cellular_component +def: "The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster." [GOC:krc, PMID:20164345, PMID:20685736, PMID:29891944] +synonym: "centriolar patch" EXACT [GOC:krc, PMID:29891944] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045177 ! apical part of cell + +[Term] +id: GO:0120221 +name: maintenance of ciliary planar beating movement pattern +namespace: biological_process +def: "Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement." [GOC:krc, PMID:26506310] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. +is_a: GO:0003352 ! regulation of cilium movement + +[Term] +id: GO:0120222 +name: regulation of blastocyst development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blastocyst development." [GOC:krc, PMID:29593216] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0001824 ! blastocyst development + +[Term] +id: GO:0120223 +name: larynx morphogenesis +namespace: biological_process +def: "The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] +synonym: "laryngeal morphogenesis" EXACT [GOC:krc, PMID:28177282] +is_a: GO:0009887 ! animal organ morphogenesis +relationship: part_of GO:0120224 ! larynx development + +[Term] +id: GO:0120224 +name: larynx development +namespace: biological_process +def: "The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration." [GOC:krc, PMID:28177282] +is_a: GO:0048513 ! animal organ development +relationship: part_of GO:0060541 ! respiratory system development + +[Term] +id: GO:0120225 +name: coenzyme A binding +namespace: molecular_function +def: "Binding to coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:krc, ISBN:0198547684] +synonym: "CoA binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0120226 +name: succinyl-CoA binding +namespace: molecular_function +def: "Binding to succinyl-CoA, an omega-carboxyacyl-CoA having succinoyl as the S-acyl component." [GOC:krc] +synonym: "succinyl-coenzyme A binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:0120227 ! acyl-CoA binding + +[Term] +id: GO:0120227 +name: acyl-CoA binding +namespace: molecular_function +def: "Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid." [GOC:krc] +synonym: "acyl binding" BROAD [] +synonym: "acyl-coenzyme A binding" EXACT [] +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0033218 ! amide binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:0120228 +name: outer dynein arm docking complex +namespace: cellular_component +def: "A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules." [GOC:krc, PMID:15064350, PMID:24067530, PMID:25192045, PMID:27486780, PMID:8045937] +synonym: "ODA docking complex" RELATED [PMID:27486780] +synonym: "ODA-DC" RELATED [PMID:27486780] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:0120229 +name: protein localization to motile cilium +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a motile cilium." [GOC:krc, PMID:27486780] +synonym: "protein localization to nonmotile primary cilium" RELATED [] +is_a: GO:0061512 ! protein localization to cilium + +[Term] +id: GO:0120230 +name: recombinase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a recombinase." [GOC:mah, PMID:32414915] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0120231 +name: DNA recombinase auxiliary factor complex +namespace: cellular_component +def: "A protein complex that binds to a recombinase and incrseases its activity." [PMID:32414915] +synonym: "DNA recombinase accessory factor complex" EXACT [PMID:32414915] +synonym: "DNA recombinase activator complex" EXACT [PMID:32414915] +is_a: GO:0150005 ! enzyme activator complex + +[Term] +id: GO:0120232 +name: prenyl-FMNH2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754] +synonym: "prenyl-FMNH2 anabolism" EXACT [] +synonym: "prenyl-FMNH2 biosynthesis" EXACT [] +synonym: "prenyl-FMNH2 formation" EXACT [] +synonym: "prenyl-FMNH2 synthesis" EXACT [] +synonym: "prenylated FMNH2 anabolism" EXACT [] +synonym: "prenylated FMNH2 biosynthesis" EXACT [] +synonym: "prenylated FMNH2 biosynthetic process" EXACT [] +synonym: "prenylated FMNH2 formation" EXACT [] +synonym: "prenylated FMNH2 synthesis" EXACT [] +is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process +is_a: GO:0009260 ! ribonucleotide biosynthetic process +is_a: GO:0042727 ! flavin-containing compound biosynthetic process + +[Term] +id: GO:0120233 +name: prenyl-FMNH2 binding +namespace: molecular_function +def: "Binding to prenyl-FMNH2, a flavin mononucleotide obtained by prenylation of the N-10 position of FMNH2 followed by cyclisation. An essential cofactor for the decarboxylase enzymes UbiD and Fdc1." [GOC:krc, PMID:25647642, PMID:26083743, PMID:26083754] +synonym: "prenylated FMNH2 binding" EXACT [] +is_a: GO:0032553 ! ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0120234 +name: stereocilium coat +namespace: cellular_component +def: "A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle." [GOC:krc, ISBN:9781461268918, PMID:31444330, PMID:3583936] +synonym: "auditory hair cell glycocalyx" BROAD [] +synonym: "stereocilium glycocalyx" EXACT [] +is_a: GO:0030112 ! glycocalyx +relationship: part_of GO:0032420 ! stereocilium + +[Term] +id: GO:0120235 +name: regulation of posttranslational protein targeting to membrane, translocation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane." [GOC:krc, GOC:rn, PMID:32513868] +synonym: "regulation of N-terminal signal peptide-independent translocation into the ER" NARROW [GOC:rn] +synonym: "regulation of posttranslational endoplasmic reticulum membrane protein translocation" EXACT [GOC:rn] +synonym: "regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation" NARROW [GOC:rn] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0034762 ! regulation of transmembrane transport +relationship: regulates GO:0031204 ! posttranslational protein targeting to membrane, translocation + +[Term] +id: GO:0120236 +name: negative regulation of posttranslational protein targeting to membrane, translocation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane." [GOC:krc, GOC:rn, PMID:32513868] +synonym: "negative regulation of N-terminal signal peptide-independent translocation into the ER" NARROW [GOC:rn] +synonym: "negative regulation of posttranslational endoplasmic reticulum membrane protein translocation" EXACT [GOC:rn] +synonym: "negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation" NARROW [GOC:rn] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:0120235 ! regulation of posttranslational protein targeting to membrane, translocation +relationship: negatively_regulates GO:0031204 ! posttranslational protein targeting to membrane, translocation + +[Term] +id: GO:0120237 +name: terminal acetylenic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "terminal alkyne substituted compound anabolic process" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound anabolism" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound biosynthesis" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound biosynthetic process" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound synthesis" EXACT [GOC:krc] +is_a: GO:0120244 ! terminal acetylenic compound metabolic process +is_a: GO:0120247 ! acetylenic compound biosynthetic process + +[Term] +id: GO:0120238 +name: sperm glycocalyx +namespace: cellular_component +def: "The carbohydrate rich layer at the outermost periphery of a sperm cell." [GOC:krc] +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0120239 +name: vascular endothelial glycocalyx +namespace: cellular_component +def: "The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated." [GOC:krc, PMID:17256154] +synonym: "endothelial glycocalyx" EXACT [] +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0120240 +name: platelet glycocalyx +namespace: cellular_component +def: "The carbohydrate rich layer at the outermost periphery of a platelet." [GOC:krc, PMID:24967889] +is_a: GO:0030112 ! glycocalyx + +[Term] +id: GO:0120241 +name: 2-iminobutanoate/2-iminopropanoate deaminase +namespace: molecular_function +def: "Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17." [EC:3.5.99.10] +comment: This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates (from EC:3.5.99.10). +synonym: "2-iminobutanoate deaminase" NARROW [EC:3.5.99.10] +synonym: "2-iminopropanoate deaminase" NARROW [EC:3.5.99.10] +synonym: "enamine/imine deaminase" BROAD [EC:3.5.99.10] +synonym: "imine intermediate deaminase activity" RELATED [] {comment="EC:3.5.99.10"} +xref: EC:3.5.99.10 +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds +is_a: GO:0019239 ! deaminase activity + +[Term] +id: GO:0120242 +name: 2-iminobutanoate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)." [RHEA:39975] +synonym: "2-iminobutanoate/2-iminopropanoate deaminase" BROAD [EC:3.5.99.10] +xref: KEGG_REACTION:R11098 +xref: MetaCyc:RXN-15123 +xref: RHEA:39975 +is_a: GO:0120241 ! 2-iminobutanoate/2-iminopropanoate deaminase + +[Term] +id: GO:0120243 +name: 2-iminopropanoate deaminase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate." [RHEA:40671] +synonym: "2-iminobutanoate/2-iminopropanoate deaminase" BROAD [EC:3.5.99.10] +xref: KEGG_REACTION:R11099 +xref: MetaCyc:RXN-15127 +xref: RHEA:40671 +is_a: GO:0120241 ! 2-iminobutanoate/2-iminopropanoate deaminase + +[Term] +id: GO:0120244 +name: terminal acetylenic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a terminal acetylenic compound, involving a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "terminal alkyne substituted compound metabolic process" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound metabolism" EXACT [GOC:krc] +is_a: GO:0120246 ! acetylenic compound metabolic process + +[Term] +id: GO:0120245 +name: terminal acetylenic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a terminal acetylenic compound, a compound which contains a terminal alkyne moiety in which a carbon of the carbon-carbon triple bond (aka C#C) moiety is attached to a hydrogen atom." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "terminal alkyne substituted compound breakdown" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound catabolic process" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound catabolism" EXACT [GOC:krc] +synonym: "terminal alkyne substituted compound degradation" EXACT [GOC:krc] +is_a: GO:0120244 ! terminal acetylenic compound metabolic process +is_a: GO:0120248 ! acetylenic compound catabolic process + +[Term] +id: GO:0120246 +name: acetylenic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "alkyne substituted compound metabolic process" EXACT [] +synonym: "alkyne substituted compound metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0120247 +name: acetylenic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "alkyne substituted compound anabolic process" EXACT [GOC:krc] +synonym: "alkyne substituted compound anabolism" EXACT [GOC:krc] +synonym: "alkyne substituted compound biosynthesis" EXACT [GOC:krc] +synonym: "alkyne substituted compound biosynthetic process" EXACT [GOC:krc] +synonym: "alkyne substituted compound synthesis" EXACT [GOC:krc] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0120246 ! acetylenic compound metabolic process + +[Term] +id: GO:0120248 +name: acetylenic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an acetylenic compound, any compound which contains a carbon-carbon triple bond (aka C#C)." [DOI:10.1007/978-1-4615-4913-0_3, GOC:krc] +synonym: "alkyne substituted compound breakdown" EXACT [GOC:krc] +synonym: "alkyne substituted compound catabolic process" EXACT [GOC:krc] +synonym: "alkyne substituted compound catabolism" EXACT [GOC:krc] +synonym: "alkyne substituted compound degradation" EXACT [GOC:krc] +is_a: GO:0009056 ! catabolic process +is_a: GO:0120246 ! acetylenic compound metabolic process + +[Term] +id: GO:0120249 +name: lateral wall of outer hair cell +namespace: cellular_component +def: "The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae." [GOC:krc, PMID:26352669, PMID:31920560, PMID:9412485] +synonym: "lateral wall of OHC" RELATED [GOC:krc] +synonym: "OHC lateral wall" RELATED [GOC:krc] +synonym: "outer hair cell lateral wall" EXACT [GOC:krc] +is_a: GO:0097574 ! lateral part of cell + +[Term] +id: GO:0120250 +name: fatty acid omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]." [GOC:krc, RHEA:39023] +xref: RHEA:39023 +is_a: GO:0004497 ! monooxygenase activity +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0120251 +name: hydrocarbon biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon] +synonym: "hydrocarbon anabolism" EXACT [GOC:krc] +synonym: "hydrocarbon biosynthesis" EXACT [GOC:krc] +synonym: "hydrocarbon formation" EXACT [GOC:krc] +synonym: "hydrocarbon synthesis" EXACT [GOC:krc] +is_a: GO:0120252 ! hydrocarbon metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:0120252 +name: hydrocarbon metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon] +synonym: "hydrocarbon metabolism" EXACT [GOC:krc] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0120253 +name: hydrocarbon catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a hydrocarbon, a compound consisting of carbon and hydrogen only." [GOC:krc, Wikipedia:Hydrocarbon] +synonym: "hydrocarbon breakdown" EXACT [GOC:krc] +synonym: "hydrocarbon catabolism" EXACT [GOC:krc] +synonym: "hydrocarbon degradation" EXACT [GOC:krc] +is_a: GO:0120252 ! hydrocarbon metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:0120254 +name: olefinic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] +synonym: "alkene substituted compound metabolic process" EXACT [] +synonym: "alkene substituted compound metabolism" EXACT [] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:0120255 +name: olefinic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] +synonym: "alkene substituted compound anabolic process" EXACT [GOC:krc] +synonym: "alkene substituted compound anabolism" EXACT [GOC:krc] +synonym: "alkene substituted compound biosynthesis" EXACT [GOC:krc] +synonym: "alkene substituted compound biosynthetic process" EXACT [GOC:krc] +synonym: "alkene substituted compound synthesis" EXACT [GOC:krc] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0120256 +name: olefinic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an olefinic compound, any compound which contains a carbon-carbon double bond (aka C=C)." [GOC:krc] +synonym: "alkene substituted compound breakdown" EXACT [GOC:krc] +synonym: "alkene substituted compound catabolic process" EXACT [GOC:krc] +synonym: "alkene substituted compound catabolism" EXACT [GOC:krc] +synonym: "alkene substituted compound degradation" EXACT [GOC:krc] +is_a: GO:0009056 ! catabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:0120257 +name: peptidyl-threonine acetylation +namespace: biological_process +def: "The acetylation of peptidyl-threonine." [GOC:krc, PMID:16728640, PMID:22802624] +is_a: GO:0006473 ! protein acetylation + +[Term] +id: GO:0120258 +name: peptidyl-threonine O-acetylation +namespace: biological_process +def: "The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine." [PMID:16728640, PMID:22802624, RESID:AA0423] +xref: RESID:AA0364 +is_a: GO:0018210 ! peptidyl-threonine modification +is_a: GO:0120257 ! peptidyl-threonine acetylation + +[Term] +id: GO:0120259 +name: 7SK snRNP +namespace: cellular_component +def: "A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb." [PMID:18249148, PMID:28431135] +synonym: "snRNP 7SK" EXACT [GOC:krc] +is_a: GO:0030532 ! small nuclear ribonucleoprotein complex + +[Term] +id: GO:0120260 +name: ciliary microtubule quartet +namespace: cellular_component +def: "A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape." [DOI:10.5772/66859, GOC:ach, GOC:krc, PMID:19299460, PMID:32518185] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. +synonym: "ciliary MtQ" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton +relationship: part_of GO:0005929 ! cilium + +[Term] +id: GO:0120261 +name: regulation of heterochromatin organization +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or location of heterochromatin organization." [GOC:krc] +is_a: GO:1902275 ! regulation of chromatin organization +relationship: regulates GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0120262 +name: negative regulation of heterochromatin organization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization." [GOC:krc] +synonym: "down regulation of heterochromatin organization" EXACT [] +synonym: "down-regulation of heterochromatin organization" EXACT [] +synonym: "downregulation of heterochromatin organization" EXACT [] +synonym: "inhibition of heterochromatin organization" NARROW [] +is_a: GO:0120261 ! regulation of heterochromatin organization +is_a: GO:1905268 ! negative regulation of chromatin organization +relationship: negatively_regulates GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0120263 +name: positive regulation of heterochromatin organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heterochromatin organization." [GOC:krc] +synonym: "activation of heterochromatin organization" NARROW [] +synonym: "stimulation of heterochromatin organization" NARROW [] +synonym: "up regulation of heterochromatin organization" EXACT [] +synonym: "up-regulation of heterochromatin organization" EXACT [] +synonym: "upregulation of heterochromatin organization" EXACT [] +is_a: GO:0120261 ! regulation of heterochromatin organization +is_a: GO:1905269 ! positive regulation of chromatin organization +relationship: positively_regulates GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0120264 +name: regulation of chromosome attachment to the nuclear envelope +namespace: biological_process +def: "Any process that modulates the frequency, rate, extent or location of chromosome attachment to the nuclear envelope." [GOC:krc] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0097240 ! chromosome attachment to the nuclear envelope + +[Term] +id: GO:0120265 +name: negative regulation of chromosome attachment to the nuclear envelope +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chromosome attachment to the nuclear envelope." [GOC:krc] +synonym: "down regulation of chromosome attachment to the nuclear envelope" EXACT [] +synonym: "down-regulation of chromosome attachment to the nuclear envelope" EXACT [] +synonym: "downregulation of chromosome attachment to the nuclear envelope" EXACT [] +synonym: "inhibition of chromosome attachment to the nuclear envelope" NARROW [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0120264 ! regulation of chromosome attachment to the nuclear envelope +relationship: negatively_regulates GO:0097240 ! chromosome attachment to the nuclear envelope + +[Term] +id: GO:0120266 +name: positive regulation of chromosome attachment to the nuclear envelope +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chromosome attachment to the nuclear envelope." [GOC:krc] +synonym: "activation of chromosome attachment to the nuclear envelope" NARROW [] +synonym: "stimulation of chromosome attachment to the nuclear envelope" NARROW [] +synonym: "up regulation of chromosome attachment to the nuclear envelope" EXACT [] +synonym: "up-regulation of chromosome attachment to the nuclear envelope" EXACT [] +synonym: "upregulation of chromosome attachment to the nuclear envelope" EXACT [] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0120264 ! regulation of chromosome attachment to the nuclear envelope +relationship: positively_regulates GO:0097240 ! chromosome attachment to the nuclear envelope + +[Term] +id: GO:0120267 +name: pellicular membrane +namespace: cellular_component +def: "The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles." [GOC:ach, GOC:krc, PMID:18095354, PMID:30550896, PMID:6993644, PMID:7175771] +comment: This sub-domain of the plasma membrane excludes the ciliary and ciliary pocket membranes. +synonym: "pellicle membrane" EXACT [] +synonym: "pellicular plasma membrane" EXACT [] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0020039 ! pellicle + +[Term] +id: GO:0120268 +name: paraflagellar rod assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme." [GOC:ach, GOC:krc, PMID:23787017, PMID:32295845] +synonym: "paraflagellar rod biogenesis" EXACT [] +synonym: "paraflagellar rod formation" EXACT [] +synonym: "PFR assembly" RELATED [] +is_a: GO:0044458 ! motile cilium assembly + +[Term] +id: GO:0120269 +name: ciliary centrin arm +namespace: cellular_component +def: "A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules." [GOC:ach, GOC:krc, PMID:26540076, PMID:31217284] +comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0020016 ! ciliary pocket + +[Term] +id: GO:0120270 +name: regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274] +is_a: GO:0061013 ! regulation of mRNA catabolic process +relationship: regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts + +[Term] +id: GO:0120271 +name: negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274] +is_a: GO:0120270 ! regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +is_a: GO:1902373 ! negative regulation of mRNA catabolic process +relationship: negatively_regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts + +[Term] +id: GO:0120272 +name: positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein." [GOC:krc, PMID:24920274] +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:0120270 ! regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts +relationship: positively_regulates GO:0033621 ! nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts + +[Term] +id: GO:0120273 +name: ciliary centrin arm assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules." [GOC:ach, GOC:krc, PMID:32675283] +synonym: "ciliary centrin arm formation" RELATED [] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:0120274 +name: virus coreceptor activity +namespace: molecular_function +def: "Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:ha, GOC:krc, PMID:16051304] +synonym: "viral coreceptor activity" EXACT [] +is_a: GO:0140272 ! exogenous protein binding + +[Term] +id: GO:0120275 +name: cerebral blood circulation +namespace: biological_process +def: "The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:krc, PMID:25397684] +synonym: "cerebrum blood circulation" EXACT [] +synonym: "telencephelon blood circulation" EXACT [] +is_a: GO:0008015 ! blood circulation + +[Term] +id: GO:0120276 +name: regulation of cerebral blood circulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] +synonym: "regulation of cerebrum blood circulation" EXACT [] +synonym: "regulation of telencephalon blood circulation" EXACT [] +is_a: GO:1903522 ! regulation of blood circulation +relationship: regulates GO:0120275 ! cerebral blood circulation + +[Term] +id: GO:0120277 +name: positive regulation of cerebral blood circulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] +synonym: "activation of cerebral blood circulation" NARROW [] +synonym: "positive regulation of cerebrum blood circulation" EXACT [] +synonym: "positive regulation of telencephalon blood circulation" EXACT [] +synonym: "up regulation of cerebral blood circulation" EXACT [] +synonym: "up-regulation of cerebral blood circulation" EXACT [] +synonym: "upregulation of cerebral blood circulation" EXACT [] +is_a: GO:0120276 ! regulation of cerebral blood circulation +is_a: GO:1903524 ! positive regulation of blood circulation +relationship: positively_regulates GO:0120275 ! cerebral blood circulation + +[Term] +id: GO:0120278 +name: negative regulation of cerebral blood circulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation." [GOC:krc, PMID:25397684] +synonym: "down regulation of cerebral blood circulation" EXACT [] +synonym: "down-regulation of cerebral blood circulation" EXACT [] +synonym: "downregulation of cerebral blood circulation" EXACT [] +synonym: "inhibition of cerebral blood circulation" NARROW [] +synonym: "negative regulation of cerebrum blood circulation" EXACT [] +synonym: "negative regulation of telencephalon blood circulation" EXACT [] +is_a: GO:0120276 ! regulation of cerebral blood circulation +is_a: GO:1903523 ! negative regulation of blood circulation +relationship: negatively_regulates GO:0120275 ! cerebral blood circulation + +[Term] +id: GO:0120279 +name: Z granule +namespace: cellular_component +def: "A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans." [GOC:dr, GOC:krc, PMID:29769721, PMID:31378614, PMID:32650583] +synonym: "germline granule" BROAD [] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule +relationship: part_of GO:0060293 ! germ plasm + +[Term] +id: GO:0120280 +name: ciliary pro-basal body +namespace: cellular_component +def: "The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium." [ISBN:0198547684] +comment: Pro-basal bodies are distinct from basal bodies as they are not at the base of a cilium and are not capable of nucleating a cilium. While immature, they contain some structures in common with the mature basal body and also may contain proteins unique to the immature state. Note that cilia and eukaryotic flagella are deemed to be equivalent. In many eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. In other eukaryotic cells, centrioles are not involved in cell division but only in cilium assembly, which is thought to be the ancestral role of the centriole/basal body. +synonym: "flagellar pro-basal body" EXACT [GOC:ach] +synonym: "flagellar probasal body" EXACT [GOC:krc] +synonym: "pro-basal body" BROAD [GOC:ach] +synonym: "pro-centriole" BROAD [GOC:ach] +synonym: "probasal body" BROAD [GOC:krc] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0120281 +name: autolysosome membrane +namespace: cellular_component +def: "A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded." [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650] +is_a: GO:0000421 ! autophagosome membrane +is_a: GO:0005765 ! lysosomal membrane +relationship: part_of GO:0044754 ! autolysosome + +[Term] +id: GO:0120282 +name: autolysosome lumen +namespace: cellular_component +def: "The volume that is enclosed within the autolysosome single-membrane." [GOC:krc, GOC:nhn, PMID:17182262, PMID:24657946, PMID:26382870, PMID:32047650] +is_a: GO:0005775 ! vacuolar lumen +relationship: part_of GO:0044754 ! autolysosome + +[Term] +id: GO:0120283 +name: protein serine/threonine kinase binding +namespace: molecular_function +def: "Binding to a protein serine/threonine kinase." [GOC:krc, GOC:sl, PMID:28608965] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:0120284 +name: tryptophan binding +namespace: molecular_function +def: "Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:krc] +synonym: "Trp binding" EXACT [GOC:krc] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043169 ! cation binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:0120285 +name: tyrosine sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine." [GOC:krc, PMID:31498992] +is_a: GO:0072545 ! tyrosine binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0120286 +name: tryptophan sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan." [GOC:krc, PMID:31498992] +is_a: GO:0120284 ! tryptophan binding +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0120287 +name: regulation of aspartic endopeptidase activity, intramembrane cleaving +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437] +is_a: GO:0052548 ! regulation of endopeptidase activity +is_a: GO:1905245 ! regulation of aspartic-type peptidase activity + +[Term] +id: GO:0120288 +name: negative regulation of aspartic endopeptidase activity, intramembrane cleaving +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437] +is_a: GO:0010951 ! negative regulation of endopeptidase activity +is_a: GO:0120287 ! regulation of aspartic endopeptidase activity, intramembrane cleaving +is_a: GO:1905246 ! negative regulation of aspartic-type peptidase activity + +[Term] +id: GO:0120289 +name: positive regulation of aspartic endopeptidase activity, intramembrane cleaving +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of intramembrane cleaving aspartic-type endopeptidase activity." [GOC:krc, PMID:32616437] +is_a: GO:0010950 ! positive regulation of endopeptidase activity +is_a: GO:0120287 ! regulation of aspartic endopeptidase activity, intramembrane cleaving +is_a: GO:1905247 ! positive regulation of aspartic-type peptidase activity + +[Term] +id: GO:0120290 +name: stalled replication fork localization to nuclear periphery +namespace: biological_process +def: "A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication." [GOC:krc, GOC:mah, PMID:33159083] +synonym: "stalled replication fork localization to nuclear periphery involved in replication fork processing" EXACT [] +is_a: GO:0051641 ! cellular localization +relationship: part_of GO:0031297 ! replication fork processing + +[Term] +id: GO:0120291 +name: negative regulation of mitotic recombination involved in replication fork processing +namespace: biological_process +def: "Any process that inhibits or decreases the rate of mitotic DNA recombination during replication fork processing. Suppression of recombination at replication forks is necessary to prevent template switching." [GOC:krc, GOC:mah, PMID:28586299, PMID:30667359, PMID:31149897] +synonym: "maintenance of template fidelity during replication fork processing" EXACT [] +synonym: "negative regulation of template switch recombination involved in replication fork processing" EXACT [] +synonym: "suppression of template switching during replication fork processing" EXACT [] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045950 ! negative regulation of mitotic recombination +is_a: GO:1903221 ! regulation of mitotic recombination involved in replication fork processing +relationship: negatively_regulates GO:1903211 ! mitotic recombination involved in replication fork processing +relationship: part_of GO:0031297 ! replication fork processing + +[Term] +id: GO:0120292 +name: positive regulation of mitotic recombination-dependent replication fork processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:krc, GOC:mah, PMID:23093942, PMID:28586299, PMID:31149897] +synonym: "positive regulation of homologous recombination dependent replication fork recovery" RELATED [PMID:23093942] +synonym: "positive regulation of homologous recombination-dependent replication fork processing" EXACT [] +synonym: "positive regulation of recombination-dependent DNA replication" EXACT [] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:1990426 ! mitotic recombination-dependent replication fork processing + +[Term] +id: GO:0120293 +name: dynein axonemal particle +namespace: cellular_component +def: "An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm." [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282] +synonym: "DynAP" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:0120294 +name: peptide serotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:14697203] +xref: RHEA:66552 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0120295 +name: histone serotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+)." [GOC:sp, PMID:30867594] +is_a: GO:0120294 ! peptide serotonyltransferase activity + +[Term] +id: GO:0120296 +name: peptide dopaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:22858378, PMID:32273471] +xref: RHEA:66556 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0120297 +name: histone dopaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+)." [GOC:sp, PMID:32273471] +is_a: GO:0120296 ! peptide dopaminyltransferase activity + +[Term] +id: GO:0120298 +name: peptide noradrenalinyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)." [GOC:sp, PMID:22858378] +xref: RHEA:66560 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0120299 +name: peptide histaminyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]." [GOC:sp, PMID:23022564, PMID:23797785] +xref: RHEA:66564 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0120300 +name: peptide lactyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]." [GOC:sp, PMID:31645732, RHEA:61996] +xref: RHEA:61996 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0120301 +name: histone lactyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[histone]." [GOC:sp, PMID:31645732] +is_a: GO:0120300 ! peptide lactyltransferase activity + +[Term] +id: GO:0120302 +name: background adaptation +namespace: biological_process +def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity." [GOC:cvs, GOC:krc, PMID:10493760, PMID:29239123, PMID:32898924] +is_a: GO:0009642 ! response to light intensity +is_a: GO:0120305 ! regulation of pigmentation + +[Term] +id: GO:0120303 +name: visually-mediated background adaptation +namespace: biological_process +def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells." [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924] +is_a: GO:0120302 ! background adaptation + +[Term] +id: GO:0120304 +name: integument-mediated background adaptation +namespace: biological_process +def: "Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument." [GOC:cvs, GOC:krc, PMID:29239123, PMID:32898924] +is_a: GO:0120302 ! background adaptation + +[Term] +id: GO:0120305 +name: regulation of pigmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism." [GOC:krc] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0043473 ! pigmentation + +[Term] +id: GO:0120306 +name: cellular response to actin cytoskeletal stress +namespace: biological_process +alt_id: GO:1903956 +alt_id: GO:1903957 +alt_id: GO:1904804 +alt_id: GO:1904805 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton." [GOC:krc, GOC:vw, PMID:32915139] +synonym: "cellular response to actin cytoskeleton stress" EXACT [GOC:krc] +synonym: "cellular response to latrunculin A" NARROW [GOC:vw] +synonym: "cellular response to latrunculin B" NARROW [GOC:vw] +synonym: "response to latrunculin A" NARROW [GOC:vw] +synonym: "response to latrunculin B" NARROW [GOC:vw] +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0120307 +name: Hechtian strand +namespace: cellular_component +def: "An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely." [GOC:krc, PMID:32397402] +xref: Wikipedia:Hechtian_strand +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0120308 +name: axonemal outer doublet assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule." [GOC:ach, GOC:krc, PMID:16278296] +synonym: "axonemal outer doublet biogenesis" EXACT [] +synonym: "axonemal outer doublet formation" EXACT [] +synonym: "axonemal outer doublet morphogenesis" EXACT [] +synonym: "axoneme outer doublet assembly" EXACT [] +synonym: "outer doublet assembly" BROAD [] +synonym: "outer-doublet microtubule assembly" BROAD [] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0035082 ! axoneme assembly + +[Term] +id: GO:0120309 +name: cilium attachment to cell body +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species." [GOC:ach, GOC:krc, PMID:11877446, PMID:18820079, PMID:22623724, PMID:26272611] +synonym: "cilial attachment to cell body" EXACT [GOC:ach] +synonym: "ciliary attachment to cell body" EXACT [GOC:ach] +synonym: "flagellar attachment to cell body" EXACT [GOC:ach] +synonym: "flagellum attachment to cell body" EXACT [GOC:ach] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0044782 ! cilium organization + +[Term] +id: GO:0120310 +name: amastigogenesis +namespace: biological_process +def: "The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites." [DOI:10.5772/intechopen.84639, GOC:ach, GOC:krc, PMID:12377273, PMID:13129524, PMID:26752404] +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0120311 +name: ciliary pro-basal body maturation +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium." [GOC:ach, GOC:krc, PMID:26862392] +synonym: "flagellar pro-basal body maturation" RELATED [GOC:ach] +synonym: "flagellar probasal body maturation" RELATED [GOC:ach] +synonym: "pro-basal body maturation" RELATED [GOC:ach] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0032053 ! ciliary basal body organization + +[Term] +id: GO:0120312 +name: ciliary basal body segregation +namespace: biological_process +def: "The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites." [GOC:ach, GOC:krc, PMID:1876188, PMID:26272611, PMID:26862392, PMID:27252853, PMID:4055898] +synonym: "ciliary basal body separation" NARROW [GO:ach] +synonym: "microtubule basal body segregation" EXACT [GO:ach] +synonym: "microtubule basal body separation" NARROW [GO:ach] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0120313 +name: regulation of oocyte karyosome formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0030717 ! oocyte karyosome formation + +[Term] +id: GO:0120314 +name: negative regulation of oocyte karyosome formation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0120313 ! regulation of oocyte karyosome formation +is_a: GO:2000242 ! negative regulation of reproductive process +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0030717 ! oocyte karyosome formation + +[Term] +id: GO:0120315 +name: positive regulation of oocyte karyosome formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [GOC:ha, GOC:krc, PMID:33382409] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0120313 ! regulation of oocyte karyosome formation +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0030717 ! oocyte karyosome formation + +[Term] +id: GO:0120316 +name: sperm flagellum assembly +namespace: biological_process +def: "The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium)." [GOC:krc, PMID:32791035] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0044458 ! motile cilium assembly +relationship: part_of GO:0007286 ! spermatid development +relationship: part_of GO:0030317 ! flagellated sperm motility + +[Term] +id: GO:0120317 +name: sperm mitochondrial sheath assembly +namespace: biological_process +def: "The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum." [GOC:krc, PMID:32791035] +is_a: GO:0003006 ! developmental process involved in reproduction +relationship: part_of GO:0120316 ! sperm flagellum assembly + +[Term] +id: GO:0120318 +name: olfactory sociosexual communication +namespace: biological_process +def: "The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system." [GOC:krc, PMID:17935991] +comment: Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. +is_a: GO:0007610 ! behavior +is_a: GO:0051703 ! biological process involved in intraspecies interaction between organisms + +[Term] +id: GO:0120319 +name: long-chain fatty acid omega-1 hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase." [GOC:nhn, PMID:18577768, PMID:22772592, PMID:24242247, RHEA:60936] +synonym: "cytochrome P450 fatty acid omega-1 hydroxylase activity" RELATED [] +xref: RHEA:60936 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0120320 +name: lateral pseudopodium retraction +namespace: biological_process +def: "The myosin-based contraction and retraction of a lateral pseudopodium." [GOC:krc, GOC:pf, PMID:12953059, PMID:15483055, PMID:17623773] +synonym: "lateral pseudopodium suppression" RELATED [] +is_a: GO:0031270 ! pseudopodium retraction + +[Term] +id: GO:0120321 +name: nuclear envelope adjacent to nuclear pore complex +namespace: cellular_component +def: "The region of the nuclear envelope situated in close proximity to a nuclear pore complex." [GOC:mah, PMID:21802294, PMID:24184107] +synonym: "associated with the nuclear pore" RELATED [GOC:mah] +synonym: "nuclear envelope adjacent to NPC" EXACT [GOC:mah] +synonym: "nuclear envelope periphery of the nuclear pore complex" EXACT [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005635 ! nuclear envelope + +[Term] +id: GO:0120322 +name: lipid modification by small protein conjugation +namespace: biological_process +def: "A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid." [GOC:sp, PMID:34012115] +is_a: GO:0030258 ! lipid modification + +[Term] +id: GO:0120323 +name: lipid ubiquitination +namespace: biological_process +def: "The process in which one or more ubiquitin groups are added to a lipid." [GOC:sp, PMID:34012115] +is_a: GO:0120322 ! lipid modification by small protein conjugation + +[Term] +id: GO:0120324 +name: procyclogenesis +namespace: biological_process +def: "The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei." [GOC:ach, https://www.cdc.gov/parasites/sleepingsickness/biology.html, PMID:10593184, PMID:1698624, PMID:17997129, PMID:3194362, PMID:3194363] +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0120325 +name: NuRD complex binding +namespace: molecular_function +def: "Binding to a NuRD complex." [GOC:krc, GOC:lb, PMID:25150861] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0120326 +name: appressorium-mediated entry into host +namespace: biological_process +def: "Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ach, GOC:krc, PMID:14731267, PMID:22589729] +synonym: "appressorium-mediated host invasion" EXACT [GOC:ach] +synonym: "appressorium-mediated host penetration" EXACT [GOC:ach] +synonym: "appressorium-mediated invasion into host" EXACT [GOC:ach] +synonym: "appressorium-mediated penetration into host" EXACT [] {EXACT="GOC:ach"} +is_a: GO:0044409 ! entry into host + +[Term] +id: GO:0120327 +name: telopode +namespace: cellular_component +def: "A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions." [GOC:krc, MESH:D000067617, PMID:20367664] +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:0120328 +name: ATP-dependent DNA (cytosine-5-)-methyltransferase activity +namespace: molecular_function +def: "Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis." [GOC:krc, PMID:31955845, PMID:32437639] +is_a: GO:0003886 ! DNA (cytosine-5-)-methyltransferase activity +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0140007 +name: KICSTOR complex +namespace: cellular_component +def: "A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2." [PMID:28199306] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0140009 +name: L-aspartate import across plasma membrane +namespace: biological_process +def: "The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000069, PMID:7914198] +is_a: GO:0070778 ! L-aspartate transmembrane transport +is_a: GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:0140010 +name: D-aspartate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of D-aspartate from one side of a membrane to the other." [GO_REF:0000070, PMID:7914198] +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity +is_a: GO:0042943 ! D-amino acid transmembrane transporter activity + +[Term] +id: GO:0140013 +name: meiotic nuclear division +namespace: biological_process +def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [PMID:9334324] +subset: goslim_generic +synonym: "meiosis" EXACT [] +is_a: GO:0000280 ! nuclear division +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0140014 +name: mitotic nuclear division +namespace: biological_process +def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] +subset: goslim_chembl +subset: goslim_generic +synonym: "mitosis" EXACT [] +is_a: GO:0000280 ! nuclear division +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:0140018 +name: regulation of cytoplasmic translational fidelity +namespace: biological_process +def: "Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code." [PMID:22768388] +is_a: GO:0006450 ! regulation of translational fidelity +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation + +[Term] +id: GO:0140020 +name: DNA methyltransferase complex +namespace: cellular_component +def: "A protein complex that possesses DNA methyltransferase activity." [PMID:20939822, PMID:24947342] +is_a: GO:0034708 ! methyltransferase complex + +[Term] +id: GO:0140021 +name: mitochondrial ADP transmembrane transport +namespace: biological_process +def: "The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:2541251] +is_a: GO:0015866 ! ADP transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140022 +name: cnida +namespace: cellular_component +def: "A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria." [Wikipedia:Cnida#Structure_and_function] +synonym: "cnidae (plural)" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0140023 +name: tRNA adenosine deamination to inosine +namespace: biological_process +def: "The removal of an amine group from an adenosine to produce inosine within a tRNA molecule." [PMID:27974624] +synonym: "A-to-I tRNA editing" EXACT [] +is_a: GO:0006400 ! tRNA modification + +[Term] +id: GO:0140024 +name: plus-end-directed endosome transport along mitotic spindle midzone microtubule +namespace: biological_process +def: "The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination." [PMID:24803650, PMID:25706234] +is_a: GO:0072383 ! plus-end-directed vesicle transport along microtubule + +[Term] +id: GO:0140025 +name: contractile vacuole tethering involved in discharge +namespace: biological_process +def: "The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion." [PMID:22323285] +synonym: "contractile vacuole tethering to plasma membrane" NARROW [] +is_a: GO:0006903 ! vesicle targeting +is_a: GO:0090522 ! vesicle tethering involved in exocytosis +relationship: part_of GO:0070177 ! contractile vacuole discharge + +[Term] +id: GO:0140026 +name: contractile vacuole dissociation from plasma membrane +namespace: biological_process +def: "The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network." [PMID:22323285] +synonym: "contractile vacuole detethering from plasma membrane" EXACT [] +is_a: GO:0016192 ! vesicle-mediated transport + +[Term] +id: GO:0140027 +name: contractile vacuole localization +namespace: biological_process +def: "The directed movement of the contractile vacuole to a specific location." [PMID:19687255] +synonym: "establishment of contractile vacuole localization" NARROW [] +is_a: GO:0051648 ! vesicle localization +is_a: GO:1990849 ! vacuolar localization + +[Term] +id: GO:0140028 +name: pore formation during contractile vacuole discharge +namespace: biological_process +def: "The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes." [PMID:22323285, Wikipedia:Exocytosis] +is_a: GO:0140029 ! exocytic process +relationship: part_of GO:0070177 ! contractile vacuole discharge + +[Term] +id: GO:0140029 +name: exocytic process +namespace: biological_process +def: "The cellular processes that contribute to exocytosis." [Wikipedia:Exocytosis] +subset: gocheck_do_not_annotate +is_a: GO:0009987 ! cellular process +relationship: part_of GO:0006887 ! exocytosis + +[Term] +id: GO:0140030 +name: modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon post-translation modification of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. +synonym: "modified protein binding" RELATED [] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:0140031 +name: phosphorylation-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon phosphorylation of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of the protein to another region; this type of phosphorylation-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0140032 +name: glycosylation-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon glycosylation of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the protein to another region; this type of glycosylation-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0140033 +name: acetylation-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon acetylation of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0140034 +name: methylation-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon methylation of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein to another region; this type of methylation-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0140035 +name: ubiquitination-like modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon modification by a ubiquitin-like protein of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0140036 +name: ubiquitin-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon ubiquitination of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the protein to another region; this type of ubiquitination-dependent protein binding is valid for annotation to this term. +is_a: GO:0140035 ! ubiquitination-like modification-dependent protein binding + +[Term] +id: GO:0140037 +name: sumo-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon sumoylation of the target protein." [PMID:26060076] +comment: This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein to another region; this type of sumoylation-dependent protein binding is valid for annotation to this term. +is_a: GO:0140035 ! ubiquitination-like modification-dependent protein binding + +[Term] +id: GO:0140039 +name: cell-cell adhesion in response to extracellular stimulus +namespace: biological_process +def: "The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus." [PMID:14996911] +is_a: GO:0098609 ! cell-cell adhesion +relationship: part_of GO:0031668 ! cellular response to extracellular stimulus + +[Term] +id: GO:0140040 +name: mitochondrial polycistronic RNA processing +namespace: biological_process +def: "The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs." [PMID:20211597] +is_a: GO:0031426 ! polycistronic mRNA processing +is_a: GO:0090615 ! mitochondrial mRNA processing + +[Term] +id: GO:0140041 +name: cellular detoxification of methylglyoxal +namespace: biological_process +def: "Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal." [PMID:15042280] +is_a: GO:0009438 ! methylglyoxal metabolic process +is_a: GO:0110095 ! cellular detoxification of aldehyde +relationship: part_of GO:0097238 ! cellular response to methylglyoxal + +[Term] +id: GO:0140042 +name: lipid droplet formation +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts of a lipid droplet." [PMID:28011631] +synonym: "adiposome formation" EXACT [] +synonym: "lipid body formation" EXACT [] +synonym: "lipid particle formation" EXACT [] +is_a: GO:0034389 ! lipid droplet organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly +relationship: part_of GO:0019915 ! lipid storage + +[Term] +id: GO:0140043 +name: lipid droplet localization to prospore membrane leading edge +namespace: biological_process +def: "Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge." [PMID:28011631] +synonym: "adiposome localization to ascospore-type prospore membrane leading edge" EXACT [] +synonym: "adiposome localization to forespore membrane leading edge" RELATED [] +synonym: "adiposome localization to FSM membrane leading edge" EXACT [] +synonym: "lipid body localization to ascospore-type prospore membrane leading edge" EXACT [] +synonym: "lipid body localization to forespore membrane leading edge" RELATED [] +synonym: "lipid body localization to FSM membrane leading edge" EXACT [] +synonym: "lipid particle localization to ascospore-type prospore membrane leading edge" EXACT [] +synonym: "lipid particle localization to forespore membrane leading edge" RELATED [] +synonym: "lipid particle localization to FSM membrane leading edge" EXACT [] +is_a: GO:0010876 ! lipid localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0140048 +name: manganese ion export across plasma membrane +namespace: biological_process +def: "The directed movement of manganese ions from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:25319704] +synonym: "manganese ion export from cell" EXACT [] +is_a: GO:0070839 ! metal ion export +is_a: GO:0071421 ! manganese ion transmembrane transport +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0140049 +name: regulation of endocardial cushion to mesenchymal transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] +is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition +relationship: regulates GO:0090500 ! endocardial cushion to mesenchymal transition + +[Term] +id: GO:0140050 +name: negative regulation of endocardial cushion to mesenchymal transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] +is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition +is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition +relationship: negatively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition + +[Term] +id: GO:0140051 +name: positive regulation of endocardial cushion to mesenchymal transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:21778427] +is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition +is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition +relationship: positively_regulates GO:0090500 ! endocardial cushion to mesenchymal transition + +[Term] +id: GO:0140052 +name: cellular response to oxidised low-density lipoprotein particle stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus." [GOC:aruk, GOC:BHF, PMID:20037584, PMID:27607416] +synonym: "cellular response to ox-LDL particle stimulus" EXACT [] +synonym: "cellular response to oxidised LDL particle stimulus" EXACT [] +synonym: "cellular response to oxidized LDL particle stimulus" EXACT [] +synonym: "cellular response to oxidized low-density lipoprotein particle stimulus" EXACT [] +synonym: "cellular response to oxLDL particle stimulus" EXACT [] +is_a: GO:0055094 ! response to lipoprotein particle +is_a: GO:0071402 ! cellular response to lipoprotein particle stimulus + +[Term] +id: GO:0140053 +name: mitochondrial gene expression +namespace: biological_process +def: "The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [PMID:27058308] +subset: goslim_generic +subset: goslim_pombe +is_a: GO:0010467 ! gene expression + +[Term] +id: GO:0140056 +name: organelle localization by membrane tethering +namespace: biological_process +def: "The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other." [PMID:27875684] +subset: goslim_pombe +is_a: GO:0022406 ! membrane docking +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:0140057 +name: vacuole-mitochondria membrane tethering +namespace: biological_process +def: "The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:27875684] +is_a: GO:0140056 ! organelle localization by membrane tethering + +[Term] +id: GO:0140058 +name: neuron projection arborization +namespace: biological_process +def: "The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:aruk, GOC:bc, PMID:17114044, PMID:23270857, PMID:23764288] +synonym: "branching morphogenesis of a neurite" RELATED [] +synonym: "branching morphogenesis of a neuron projection" RELATED [] +synonym: "neurite arborization" EXACT [] +synonym: "neurite branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044] +synonym: "neuron projection branching" EXACT [GOC:aruk, GOC:bc, PMID:17114044] +is_a: GO:0048812 ! neuron projection morphogenesis + +[Term] +id: GO:0140059 +name: dendrite arborization +namespace: biological_process +def: "The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:23270857] +is_a: GO:0048813 ! dendrite morphogenesis +is_a: GO:0140058 ! neuron projection arborization + +[Term] +id: GO:0140060 +name: axon arborization +namespace: biological_process +def: "The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches." [GOC:aruk, GOC:bc, PMID:23764288] +is_a: GO:0007409 ! axonogenesis +is_a: GO:0140058 ! neuron projection arborization + +[Term] +id: GO:0140061 +name: 5-hydroxymethylcytosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2." [PMID:27918559] +synonym: "5hmC dioxygenase" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0140062 +name: 5-formylcytosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2." [PMID:27918559] +synonym: "5fC dioxygenase" EXACT [] +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity + +[Term] +id: GO:0140064 +name: peptide crotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide." [PMID:25818647] +synonym: "protein crotonyltransferase activity" RELATED [] +xref: RHEA:53908 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0140065 +name: peptide butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide." [PMID:27105113] +synonym: "protein butyryltransferase activity" RELATED [] +xref: RHEA:53912 +is_a: GO:0016410 ! N-acyltransferase activity + +[Term] +id: GO:0140066 +name: peptidyl-lysine crotonylation +namespace: biological_process +def: "The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid." [PMID:25818647, Wikipedia:crotonyl] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0140067 +name: peptidyl-lysine butyrylation +namespace: biological_process +def: "The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid." [PMID:27105113, Wikipedia:butyryl] +is_a: GO:0043543 ! protein acylation + +[Term] +id: GO:0140068 +name: histone crotonyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone." [PMID:25818647] +is_a: GO:0140064 ! peptide crotonyltransferase activity + +[Term] +id: GO:0140069 +name: histone butyryltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone." [PMID:27105113] +is_a: GO:0140065 ! peptide butyryltransferase activity + +[Term] +id: GO:0140074 +name: cardiac endothelial to mesenchymal transition +namespace: biological_process +def: "A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes." [GOC:BHF, GOC:nc, PMID:16162442, PMID:26053665] +synonym: "EndMT" EXACT [PMID:28181491] +synonym: "EndoMT" EXACT [] +is_a: GO:0048762 ! mesenchymal cell differentiation + +[Term] +id: GO:0140075 +name: regulation of lipoprotein transport +namespace: biological_process +def: "Any process that controls lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] +is_a: GO:0051223 ! regulation of protein transport +relationship: regulates GO:0042953 ! lipoprotein transport + +[Term] +id: GO:0140076 +name: negative regulation of lipoprotein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] +is_a: GO:0051224 ! negative regulation of protein transport +is_a: GO:0140075 ! regulation of lipoprotein transport +relationship: negatively_regulates GO:0042953 ! lipoprotein transport + +[Term] +id: GO:0140077 +name: positive regulation of lipoprotein transport +namespace: biological_process +def: "Any process that activates or increases the rate or extent of lipoprotein transport." [GOC:BHF, GOC:BHF_miRNA, GOC:RPH, PMID:26501192] +is_a: GO:0051222 ! positive regulation of protein transport +is_a: GO:0140075 ! regulation of lipoprotein transport +relationship: positively_regulates GO:0042953 ! lipoprotein transport + +[Term] +id: GO:0140078 +name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate." [PMID:1698278, RHEA:66592] +comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV. +synonym: "AP endonuclease class I activity" RELATED [] +synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [] +synonym: "class I DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] +synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [] +synonym: "DNA-(apurinic or apyrimidinic site) lyase activity" EXACT [] +xref: EC:4.2.99.18 +xref: MetaCyc:4.2.99.18-RXN +xref: RHEA:66592 +xref: Wikipedia:AP_endonuclease +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity +is_a: GO:0016835 ! carbon-oxygen lyase activity + +[Term] +id: GO:0140080 +name: class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity +namespace: molecular_function +def: "Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH." [PMID:2519777] +comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV. +synonym: "endonuclease III" RELATED [] +synonym: "endonuclease IV" RELATED [] +xref: Wikipedia:AP_endonuclease +is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity + +[Term] +id: GO:0140081 +name: glycosylated region protein binding +namespace: molecular_function +def: "Binding to a glycosylated region of a protein." [GOC:pg] +is_a: GO:0005515 ! protein binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:0140082 +name: SUMO-ubiquitin ligase activity +namespace: molecular_function +def: "Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue." [PMID:28552615] +is_a: GO:0061665 ! SUMO ligase activity + +[Term] +id: GO:0140083 +name: ATP-dependent protein-DNA unloading activity +namespace: molecular_function +def: "Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction." [PMID:28552615] +synonym: "protein-DNA unloading ATPase activity" EXACT [] +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0140084 +name: sexual macrocyst formation +namespace: biological_process +def: "The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum." [PMID:16592095, PMID:20089169] +synonym: "macrocyst formation" RELATED [] +synonym: "sexual fusion" RELATED [] +is_a: GO:0019953 ! sexual reproduction + +[Term] +id: GO:0140090 +name: membrane curvature sensor activity +namespace: molecular_function +def: "Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins." [PMID:25898166] +is_a: GO:0008289 ! lipid binding + +[Term] +id: GO:0140091 +name: mBAF complex +namespace: cellular_component +def: "A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof." [GO:bhm, PMID:11175787, PMID:12620226, PMID:15525990, PMID:8804307, PMID:8895581] +synonym: "muscle-specific BAF complex" EXACT [] +synonym: "muscle-specific SWI/SNF complex" EXACT [] +synonym: "muscle-type BAF complex" EXACT [] +synonym: "muscle-type SWI/SNF complex" EXACT [] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0140092 +name: bBAF complex +namespace: cellular_component +def: "A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180." [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581] +synonym: "brain-specific BAF complex" EXACT [] +synonym: "brain-specific SWI/SNF complex" EXACT [] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0140093 +name: esBAF complex +namespace: cellular_component +def: "An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C." [GOC:bhm, PMID:19279218, PMID:19279220, PMID:2620226, PMID:8804307, PMID:8895581] +synonym: "embryonic stem cell-specific BAF complex" EXACT [] +synonym: "embryonic stem cell-specific SWI/SNF complex" EXACT [] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0140096 +name: catalytic activity, acting on a protein +namespace: molecular_function +def: "Catalytic activity that acts to modify a protein." [GOC:molecular_function_refactoring, GOC:pdt] +subset: goslim_generic +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0140097 +name: catalytic activity, acting on DNA +namespace: molecular_function +def: "Catalytic activity that acts to modify DNA." [GOC:molecular_function_refactoring, GOC:pdt] +subset: goslim_generic +is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid + +[Term] +id: GO:0140098 +name: catalytic activity, acting on RNA +namespace: molecular_function +def: "Catalytic activity that acts to modify RNA, driven by ATP hydrolysis." [GOC:molecular_function_refactoring, GOC:pdt] +subset: goslim_generic +is_a: GO:0140640 ! catalytic activity, acting on a nucleic acid + +[Term] +id: GO:0140101 +name: catalytic activity, acting on a tRNA +namespace: molecular_function +def: "Catalytic activity that acts to modify a tRNA." [GOC:molecular_function_refactoring, GOC:pdt] +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0140102 +name: catalytic activity, acting on a rRNA +namespace: molecular_function +def: "Catalytic activity that acts to modify a ribosomal RNA." [GOC:molecular_function_refactoring, GOC:pdt] +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0140103 +name: catalytic activity, acting on a glycoprotein +namespace: molecular_function +def: "Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein." [GOC:molecular_function_refactoring, GOC:pdt] +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0140104 +name: molecular carrier activity +namespace: molecular_function +def: "Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location." [GOC:molecular_function_refactoring, GOC:pdt] +comment: Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization. +subset: gocheck_do_not_annotate +subset: goslim_generic +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140105 +name: interleukin-10-mediated signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of interleukin-10 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [PMID:11244051] +synonym: "IL-10-mediated signaling pathway" EXACT [] +synonym: "interleukin-10-mediated signalling pathway" EXACT [] +is_a: GO:0019221 ! cytokine-mediated signaling pathway + +[Term] +id: GO:0140107 +name: high-affinity potassium ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:10629185] +is_a: GO:0015079 ! potassium ion transmembrane transporter activity + +[Term] +id: GO:0140108 +name: high-affinity glucose transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:25411338] +is_a: GO:0005355 ! glucose transmembrane transporter activity + +[Term] +id: GO:0140110 +name: transcription regulator activity +namespace: molecular_function +def: "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons." [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor] +subset: gocheck_do_not_annotate +subset: goslim_flybase_ribbon +subset: goslim_plant +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140111 +name: [choline trimethylamine-lyase]-activating enzyme activity +namespace: molecular_function +def: "Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM)." [PMID:24854437] +xref: MetaCyc:RXN-16470 +is_a: GO:0043364 ! glycyl-radical enzyme activating activity + +[Term] +id: GO:0140112 +name: extracellular vesicle biogenesis +namespace: biological_process +def: "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content." [PMID:28736435] +synonym: "extracellular vesicle assembly" EXACT [] +is_a: GO:0044085 ! cellular component biogenesis + +[Term] +id: GO:0140113 +name: extracellular microvesicle biogenesis +namespace: biological_process +def: "The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding." [PMID:28736435] +synonym: "extracellular microvesicle assembly" RELATED [] +is_a: GO:0140112 ! extracellular vesicle biogenesis + +[Term] +id: GO:0140114 +name: cellular detoxification of fluoride +namespace: biological_process +def: "Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] +is_a: GO:1990748 ! cellular detoxification +relationship: part_of GO:1902618 ! cellular response to fluoride + +[Term] +id: GO:0140115 +name: export across plasma membrane +namespace: biological_process +def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg] +synonym: "efflux" BROAD [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0140352 ! export from cell + +[Term] +id: GO:0140116 +name: fluoride export across plasma membrane +namespace: biological_process +def: "The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:27327046] +is_a: GO:0140115 ! export across plasma membrane +is_a: GO:1903424 ! fluoride transmembrane transport + +[Term] +id: GO:0140121 +name: Lewy body formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a Lewy body." [PMID:15158159] +is_a: GO:0070841 ! inclusion body assembly + +[Term] +id: GO:0140122 +name: regulation of Lewy body formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Lewy body formation." [GOC:sl] +is_a: GO:0090083 ! regulation of inclusion body assembly +relationship: regulates GO:0140121 ! Lewy body formation + +[Term] +id: GO:0140123 +name: negative regulation of Lewy body formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation." [GOC:sl] +is_a: GO:0090084 ! negative regulation of inclusion body assembly +is_a: GO:0140122 ! regulation of Lewy body formation +relationship: negatively_regulates GO:0140121 ! Lewy body formation + +[Term] +id: GO:0140124 +name: positive regulation of Lewy body formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Lewy body formation." [GOC:sl] +is_a: GO:0090261 ! positive regulation of inclusion body assembly +is_a: GO:0140122 ! regulation of Lewy body formation +relationship: positively_regulates GO:0140121 ! Lewy body formation + +[Term] +id: GO:0140125 +name: thiamine import across plasma membrane +namespace: biological_process +def: "The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] +is_a: GO:0071934 ! thiamine transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140131 +name: positive regulation of lymphocyte chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis." [PMID:19255442] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:1901623 ! regulation of lymphocyte chemotaxis +is_a: GO:2000403 ! positive regulation of lymphocyte migration +relationship: positively_regulates GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:0140132 +name: iron-sulfur cluster carrier activity +namespace: molecular_function +def: "Binding to an iron-sulfur cluster and delivering it to an acceptor molecule." [PMID:22966982, PMID:29051382] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0140133 +name: suppression by symbiont of host cytokine production +namespace: biological_process +def: "Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:23083102] +synonym: "negative regulation by symbiont of host cytokine production" EXACT [] +synonym: "suppression by symbiont of host cytokine secretion" RELATED [] +is_a: GO:0052170 ! suppression by symbiont of host innate immune response + +[Term] +id: GO:0140135 +name: mechanosensitive cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens in response to a mechanical stress." [GOC:ha, PMID:22343900] +synonym: "mechanically-gated cation channel activity" EXACT [] +is_a: GO:0005261 ! cation channel activity +is_a: GO:0008381 ! mechanosensitive ion channel activity + +[Term] +id: GO:0140140 +name: mitochondrial guanine nucleotide transmembrane transport +namespace: biological_process +def: "The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:14998997] +is_a: GO:1903716 ! guanine transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140141 +name: mitochondrial potassium ion transmembrane transport +namespace: biological_process +def: "The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:20197279] +is_a: GO:0071805 ! potassium ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140142 +name: nucleocytoplasmic carrier activity +namespace: molecular_function +alt_id: GO:0061717 +alt_id: GO:0090631 +def: "Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein." [GOC:pg] +subset: gocheck_do_not_annotate +synonym: "miRNA transporter activity" NARROW [] +synonym: "nucleocytoplasmic importin/exportin activity" EXACT [] +synonym: "pre-miRNA transporter activity" NARROW [] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0140145 +name: copper ion export from vacuole +namespace: biological_process +def: "The directed movement of copper ions out of the vacuole across the vacuolar membrane." [GOC:vw, PMID:12244050] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0060003 ! copper ion export + +[Term] +id: GO:0140146 +name: calcium ion import into vacuole +namespace: biological_process +def: "The directed movement of calcium cations into the vacuole across the vacuolar membrane." [GOC:vw, PMID:8628289] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0060401 ! cytosolic calcium ion transport +is_a: GO:0070588 ! calcium ion transmembrane transport +is_a: GO:1901660 ! calcium ion export + +[Term] +id: GO:0140147 +name: zinc ion export from vacuole +namespace: biological_process +def: "The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol." [GOC:vw, PMC:PMC203372] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0070839 ! metal ion export +is_a: GO:0071577 ! zinc ion transmembrane transport + +[Term] +id: GO:0140157 +name: ammonium import across plasma membrane +namespace: biological_process +def: "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:16999738] +is_a: GO:0072488 ! ammonium transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140159 +name: borate export across plasma membrane +namespace: biological_process +def: "The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:vw, PMID:17459946] +is_a: GO:0035445 ! borate transmembrane transport +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:0140161 +name: monocarboxylate:sodium symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in)." [GOC:ln, PMID:15322102] +is_a: GO:0005343 ! organic acid:sodium symporter activity +is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity + +[Term] +id: GO:0140164 +name: Golgi transport complex binding +namespace: molecular_function +def: "Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family." [GOC:ha, PMID:28100664] +synonym: "COG complex binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0140192 +name: regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0106070 ! regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +relationship: regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140193 +name: regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0044057 ! regulation of system process +is_a: GO:0071877 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway +relationship: regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140194 +name: negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0140193 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +relationship: negatively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140195 +name: positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway +is_a: GO:0140193 ! regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process +relationship: positively_regulates GO:0086096 ! adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140196 +name: positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0071879 ! positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway +is_a: GO:0106071 ! positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway +is_a: GO:0140192 ! regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +relationship: positively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140199 +name: negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process." [GOC:BHF, GOC:BHF_miRNA, GOC:rph] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0071878 ! negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway +is_a: GO:0140192 ! regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +relationship: negatively_regulates GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process + +[Term] +id: GO:0140200 +name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate +namespace: biological_process +def: "An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction." [GOC:BHF] +is_a: GO:0086023 ! adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process +relationship: part_of GO:0003062 ! regulation of heart rate by chemical signal + +[Term] +id: GO:0140201 +name: urea import across plasma membrane +namespace: biological_process +def: "The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313] +is_a: GO:0071918 ! urea transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140202 +name: polyamine import across plasma membrane +namespace: biological_process +def: "The directed movement of a polyamine from outside of a cell, across the plasma membrane and into the cytosol." [PMID:17218313] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140203 +name: spermidine import across plasma membrane +namespace: biological_process +def: "The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] +is_a: GO:0140202 ! polyamine import across plasma membrane +is_a: GO:1903711 ! spermidine transmembrane transport + +[Term] +id: GO:0140204 +name: pyridoxal import across plasma membrane +namespace: biological_process +def: "The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1903090 ! pyridoxal transmembrane transport + +[Term] +id: GO:0140205 +name: oligopeptide import across plasma membrane +namespace: biological_process +def: "The directed movement of an oligopeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] +is_a: GO:0035672 ! oligopeptide transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140206 +name: dipeptide import across plasma membrane +namespace: biological_process +def: "The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] +is_a: GO:0035442 ! dipeptide transmembrane transport +is_a: GO:0140205 ! oligopeptide import across plasma membrane + +[Term] +id: GO:0140207 +name: tripeptide import across plasma membrane +namespace: biological_process +def: "The directed movement of a tripeptide from outside of a cell, across the plasma membrane and into the cytosol." [PMID:22226946] +is_a: GO:0035443 ! tripeptide transmembrane transport +is_a: GO:0140205 ! oligopeptide import across plasma membrane + +[Term] +id: GO:0140208 +name: apoptotic process in response to mitochondrial fragmentation +namespace: biological_process +def: "Any apoptotic process that occurs as a result of mitochondrial fragmentation." [PMID:18940801] +synonym: "apoptosis in response to mitochondrial fragmentation" EXACT [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:0140209 +name: zinc ion import into endoplasmic reticulum +namespace: biological_process +def: "The directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum." [PMID:11886869, PMID:29529046] +comment: This term covers zinc(2+) import *across* the endoplasmic reticulum membrane through a channel or pore. It does not cover import via vesicle fusion with endoplasmic reticulum membrane, as in this case transport does not involve crossing the membrane. +synonym: "zinc ion import across endoplasmic reticulum" EXACT [] +synonym: "zinc ion import into ER" EXACT [] +synonym: "zinc(2+) import across endoplasmic reticulum" EXACT [] +synonym: "zinc(2+) import into endoplasmic reticulum" EXACT [] +is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport +is_a: GO:0062111 ! zinc ion import into organelle + +[Term] +id: GO:0140210 +name: protein transport along microtubule to kinetochore +namespace: biological_process +def: "Any process in which a protein is transported to the kinetochore along a microtubule." [PMID:25472718] +is_a: GO:0034501 ! protein localization to kinetochore +is_a: GO:0070199 ! establishment of protein localization to chromosome +is_a: GO:0098840 ! protein transport along microtubule + +[Term] +id: GO:0140211 +name: folic acid:proton symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid." [PMID:24745983] +xref: TC:2.A.1.50.1 +is_a: GO:0008517 ! folic acid transmembrane transporter activity +is_a: GO:0015295 ! solute:proton symporter activity + +[Term] +id: GO:0140212 +name: regulation of long-chain fatty acid import into cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239] +is_a: GO:2000191 ! regulation of fatty acid transport +relationship: regulates GO:0044539 ! long-chain fatty acid import into cell + +[Term] +id: GO:0140213 +name: negative regulation of long-chain fatty acid import into cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239] +is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell +is_a: GO:2000192 ! negative regulation of fatty acid transport +relationship: negatively_regulates GO:0044539 ! long-chain fatty acid import into cell + +[Term] +id: GO:0140214 +name: positive regulation of long-chain fatty acid import into cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of long-chain fatty acid import into a cell." [PMID:28178239] +is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell +is_a: GO:2000193 ! positive regulation of fatty acid transport +relationship: positively_regulates GO:0044539 ! long-chain fatty acid import into cell + +[Term] +id: GO:0140215 +name: regulation of D-aspartate import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: regulates GO:0070779 ! D-aspartate import across plasma membrane + +[Term] +id: GO:0140216 +name: negative regulation of D-aspartate import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +relationship: negatively_regulates GO:0070779 ! D-aspartate import across plasma membrane + +[Term] +id: GO:0140217 +name: positive regulation of D-aspartate import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol." [PMID:27663541] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:0140215 ! regulation of D-aspartate import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +relationship: positively_regulates GO:0070779 ! D-aspartate import across plasma membrane + +[Term] +id: GO:0140220 +name: pathogen-containing vacuole +namespace: cellular_component +def: "A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides." [PMID:10560000, PMID:26842840] +synonym: "pathogen inclusion" RELATED [] +synonym: "pathogen-containing compartment" RELATED [] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0140221 +name: pathogen-containing vacuole membrane +namespace: cellular_component +def: "Host-derived membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840] +synonym: "pathogen inclusion membrane" RELATED [] +synonym: "pathogen-containing compartment membrane" EXACT [] +is_a: GO:0016020 ! membrane +relationship: part_of GO:0140220 ! pathogen-containing vacuole + +[Term] +id: GO:0140222 +name: pathogen-containing vacuole lumen +namespace: cellular_component +def: "The enclosed volume within the sealed membrane of a pathogen-containing vacuole." [PMID:10560000, PMID:26842840] +synonym: "lumen of a pathogen-containing vacuole" EXACT [] +synonym: "pathogen inclusion lumen" RELATED [] +synonym: "pathogen-containing compartment lumen" EXACT [] +synonym: "pathogen-containing vacuolar lumen" EXACT [] +is_a: GO:0031974 ! membrane-enclosed lumen +relationship: part_of GO:0140220 ! pathogen-containing vacuole + +[Term] +id: GO:0140223 +name: general transcription initiation factor activity +namespace: molecular_function +def: "A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary." [GOC:txnOH-2018] +comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation. +subset: goslim_drosophila +subset: goslim_generic +synonym: "basal transcription factor activity" EXACT [] +synonym: "general transcription factor activity" EXACT [] +synonym: "GTF activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140224 +name: SLAC complex +namespace: cellular_component +def: "A protein complex that regulates Arp2/3 complex-mediated actin nucleation." [GOC:lnp, PMID:22973053] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0140225 +name: DNA topoisomerase III-beta-TDRD3 complex +namespace: cellular_component +def: "A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities." [GOC:lnp, PMID:23912945, PMID:28176834] +synonym: "Top3-beta-TDRD3 complex" EXACT [GOC:krc] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0140226 +name: RNA topoisomerase activity +namespace: molecular_function +def: "Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA." [GOC:lnp, PMID:23912945, PMID:27257063] +is_a: GO:0016853 ! isomerase activity +is_a: GO:0140098 ! catalytic activity, acting on RNA + +[Term] +id: GO:0140227 +name: serotonin-gated cation-selective signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by serotonin binding to a seratonin receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25392484, PMID:27764665] +synonym: "5-HT-gated cation-selective signaling pathway" EXACT [] +synonym: "5-HT-gated cation-selective signalling pathway" EXACT [] +synonym: "5-hydroxytryptamine-gated cation-selective signaling pathway" EXACT [] +synonym: "5-hydroxytryptamine-gated cation-selective signalling pathway" EXACT [] +synonym: "serotonin-gated cation-selective signalling pathway" EXACT [] +is_a: GO:0007210 ! serotonin receptor signaling pathway +is_a: GO:1990806 ! ligand-gated ion channel signaling pathway + +[Term] +id: GO:0140231 +name: anterograde axonal transport of neurotransmitter receptor complex +namespace: biological_process +def: "The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons." [PMID:28680963] +subset: goslim_synapse +is_a: GO:0097120 ! receptor localization to synapse +is_a: GO:0099637 ! neurotransmitter receptor transport +is_a: GO:0099641 ! anterograde axonal protein transport + +[Term] +id: GO:0140232 +name: intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential." [PMID:21358644] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +synonym: "intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential" EXACT [] +is_a: GO:0005222 ! intracellular cAMP-activated cation channel activity + +[Term] +id: GO:0140233 +name: intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential." [GOC:pvn] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +synonym: "intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential" EXACT [] +is_a: GO:0005222 ! intracellular cAMP-activated cation channel activity + +[Term] +id: GO:0140235 +name: RNA polyadenylation at postsynapse +namespace: biological_process +def: "A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse." [PMID:22727665] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0043631 ! RNA polyadenylation + +[Term] +id: GO:0140236 +name: translation at presynapse +namespace: biological_process +def: "Translation that occurs at the presynapse." [PMID:27321671] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140241 ! translation at synapse + +[Term] +id: GO:0140237 +name: translation at presynapse, modulating chemical synaptic transmission +namespace: biological_process +def: "Translation that occurs at the presynapse, and that modulates chemical synaptic transmission." [PMID:27321671] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140236 ! translation at presynapse +relationship: regulates GO:0007268 ! chemical synaptic transmission + +[Term] +id: GO:0140238 +name: presynaptic endocytosis +namespace: biological_process +def: "A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:24719103] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0006897 ! endocytosis +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099003 ! vesicle-mediated transport in synapse + +[Term] +id: GO:0140239 +name: postsynaptic endocytosis +namespace: biological_process +def: "A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [PMID:12839988] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0006897 ! endocytosis +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099003 ! vesicle-mediated transport in synapse + +[Term] +id: GO:0140240 +name: perforant pathway to dendrate granule cell synapse +namespace: cellular_component +def: "A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus." [PMID:22727665, PMID:29199135] +subset: goslim_synapse +synonym: "perforant pathway to DG granule cell synapse" EXACT [] +is_a: GO:0045202 ! synapse + +[Term] +id: GO:0140241 +name: translation at synapse +namespace: biological_process +def: "Translation that occurs at the synapse." [PMID:23083742] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0006412 ! translation + +[Term] +id: GO:0140242 +name: translation at postsynapse +namespace: biological_process +def: "Translation that occurs at the postsynapse." [PMID:20427644] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140241 ! translation at synapse + +[Term] +id: GO:0140243 +name: regulation of translation at synapse +namespace: biological_process +def: "Any process that regulates translation occurring at the synapse." [PMID:20427644] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0006417 ! regulation of translation + +[Term] +id: GO:0140244 +name: regulation of translation at presynapse +namespace: biological_process +def: "Any process that regulates translation occurring at the presynapse." [PMID:20427644] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140243 ! regulation of translation at synapse + +[Term] +id: GO:0140245 +name: regulation of translation at postsynapse +namespace: biological_process +def: "Any process that regulates translation occurring at the postsynapse." [PMID:20427644] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140243 ! regulation of translation at synapse + +[Term] +id: GO:0140246 +name: protein catabolic process at synapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a synapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0030163 ! protein catabolic process + +[Term] +id: GO:0140247 +name: protein catabolic process at presynapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse." [PMID:27764673] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse + +[Term] +id: GO:0140249 +name: protein catabolic process at postsynapse +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140246 ! protein catabolic process at synapse + +[Term] +id: GO:0140250 +name: regulation protein catabolic process at synapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse." [PMID:23083742] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0009894 ! regulation of catabolic process + +[Term] +id: GO:0140251 +name: regulation protein catabolic process at presynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse." [PMID:27764673] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140250 ! regulation protein catabolic process at synapse + +[Term] +id: GO:0140252 +name: regulation protein catabolic process at postsynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse." [PMID:17062563] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0140250 ! regulation protein catabolic process at synapse + +[Term] +id: GO:0140253 +name: cell-cell fusion +namespace: biological_process +def: "A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium." [Wikipedia:Cell_fusion] +synonym: "cell cell fusion" EXACT [] +synonym: "cell fusion" BROAD [] +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0140255 +name: regulation of cellular response to phosphate starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0016036 ! cellular response to phosphate starvation + +[Term] +id: GO:0140256 +name: negative regulation of cellular response to phosphate starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation." [PMID:29414789] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:0140255 ! regulation of cellular response to phosphate starvation +relationship: negatively_regulates GO:0016036 ! cellular response to phosphate starvation + +[Term] +id: GO:0140259 +name: PRC1 complex binding +namespace: molecular_function +def: "Binding to a PRC1 complex." [PMID:15280237] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0140260 +name: mitochondrial proton-transporting ATP synthase complex binding +namespace: molecular_function +def: "Binding to a mitochondrial proton-transporting ATP synthase complex." [PMID:12110673] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0140261 +name: BCOR complex +namespace: cellular_component +def: "A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10." [PMID:16943429, PMID:22325352, PMID:24515802] +synonym: "BCL6 corepressor (BCOR) complex" EXACT [] +synonym: "BCOR/BCORL1 complex" EXACT [] +synonym: "non-canonical BCOR-PRC1.1 complex" EXACT [] +synonym: "non-canonical PRC1-BCOR complex" EXACT [] +synonym: "PRC1.1 complex" EXACT [] +is_a: GO:0000152 ! nuclear ubiquitin ligase complex + +[Term] +id: GO:0140262 +name: mRNA cap binding complex binding +namespace: molecular_function +def: "Binding to a mRNA cap binding complex." [PMID:16938833] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0140266 +name: Woronin body +namespace: cellular_component +def: "Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes." [PMID:12640443, PMID:15155882, PMID:18227279, PMID:20707002, PMID:23882222] +is_a: GO:0042579 ! microbody + +[Term] +id: GO:0140267 +name: viral entry via permeabilization of host membrane +namespace: biological_process +def: "The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm." [PMID:20427561, PMID:25055856] +subset: gocheck_do_not_annotate +is_a: GO:0046718 ! viral entry into host cell + +[Term] +id: GO:0140268 +name: endoplasmic reticulum-plasma membrane contact site +namespace: cellular_component +def: "A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes." [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696] +synonym: "endoplasmic reticulum-plasma membrane contact junction" EXACT [] +synonym: "EPCS" EXACT [] +synonym: "ER-plasma membrane contact site" EXACT [] +synonym: "ER-PM contact site" EXACT [] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0140270 +name: gluconate import across plasma membrane +namespace: biological_process +def: "The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] +is_a: GO:0035429 ! gluconate transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140271 +name: hexose import across plasma membrane +namespace: biological_process +def: "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] +is_a: GO:0008645 ! hexose transmembrane transport +is_a: GO:0098704 ! carbohydrate import across plasma membrane + +[Term] +id: GO:0140272 +name: exogenous protein binding +namespace: molecular_function +def: "Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein." [PMID:28861068] +comment: Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant. +is_a: GO:0005488 ! binding + +[Term] +id: GO:0140273 +name: repair of mitotic kinetochore microtubule attachment defect +namespace: biological_process +def: "The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536] +synonym: "correction of mitotic kinetochore microtubule attachment defects" EXACT [] +synonym: "repair of mitotic kinetochore microtubule attachment defects" EXACT [] +is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007080 ! mitotic metaphase plate congression + +[Term] +id: GO:0140274 +name: repair of kinetochore microtubule attachment defect +namespace: biological_process +def: "The cell cycle process where kinetochore microtubule attachment defects are corrected." [PMID:15525536] +synonym: "correction of kinetochore microtubule attachment defects" EXACT [] +synonym: "repair of kinetochore microtubule attachment defects" EXACT [] +is_a: GO:0022402 ! cell cycle process + +[Term] +id: GO:0140275 +name: MIB complex +namespace: cellular_component +def: "A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1." [PMID:26477565] +synonym: "mitochondrial intermembrane space bridging complex" EXACT [] +synonym: "mitofilin complex" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane + +[Term] +id: GO:0140276 +name: obsolete pericentric heterochromatin maintenance +namespace: biological_process +alt_id: GO:1902368 +def: "OBSOLETE. Any heterochromatin maintenance that is involved in chromatin silencing at or near a centromere." [GOC:TermGenie, GOC:vw, PMID:21289066] +comment: This term was obsoleted because it represents a phenotype. +synonym: "heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region" RELATED [] +synonym: "heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats" EXACT [GOC:vw] +synonym: "heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:0140278 +name: mitotic division septum assembly +namespace: biological_process +def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [PMID:22786806] +is_a: GO:0000917 ! division septum assembly +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:0140279 +name: regulation of mitotic division septum assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] +synonym: "regulation of division septum formation involved in mitotic cell cycle" EXACT [] +synonym: "regulation of formation of division septum involved in mitotic cell cycle" EXACT [] +synonym: "regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0032955 ! regulation of division septum assembly +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:0140278 ! mitotic division septum assembly + +[Term] +id: GO:0140280 +name: negative regulation of mitotic division septum assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] +synonym: "down regulation of division septum formation involved in mitotic cell cycle" EXACT [] +synonym: "down regulation of formation of division septum involved in mitotic cell cycle" EXACT [] +synonym: "down regulation of mitotic division septum assembly" EXACT [] +synonym: "down regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [] +synonym: "down regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [] +synonym: "down-regulation of division septum formation involved in mitotic cell cycle" EXACT [] +synonym: "down-regulation of formation of division septum involved in mitotic cell cycle" EXACT [] +synonym: "down-regulation of mitotic division septum assembly" EXACT [] +synonym: "down-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of division septum formation involved in mitotic cell cycle" EXACT [] +synonym: "downregulation of formation of division septum involved in mitotic cell cycle" EXACT [] +synonym: "downregulation of mitotic division septum assembly" EXACT [] +synonym: "downregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "inhibition of division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic division septum assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "inhibition of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of division septum formation involved in mitotic cell cycle" EXACT [] +synonym: "negative regulation of formation of division septum involved in mitotic cell cycle" EXACT [] +synonym: "negative regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0010974 ! negative regulation of division septum assembly +is_a: GO:0140279 ! regulation of mitotic division septum assembly +is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process +relationship: negatively_regulates GO:0140278 ! mitotic division septum assembly + +[Term] +id: GO:0140281 +name: positive regulation of mitotic division septum assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [PMID:22786806] +synonym: "activation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "activation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "activation of mitotic division septum assembly" EXACT [GOC:TermGenie] +synonym: "activation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "activation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic division septum assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic division septum assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of division septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of formation of division septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of septin assembly and septum biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of septin assembly and septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0010973 ! positive regulation of division septum assembly +is_a: GO:0140279 ! regulation of mitotic division septum assembly +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +relationship: positively_regulates GO:0140278 ! mitotic division septum assembly + +[Term] +id: GO:0140282 +name: carbon-nitrogen ligase activity on lipid II +namespace: molecular_function +def: "Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate." [PMID:22291598, PMID:30093673, PMID:30154570, RHEA:57928] +synonym: "L-glutamate--lipid II transaminase activity" EXACT [] +synonym: "undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity" EXACT [] +xref: EC:6.3.5.13 +xref: RHEA:57928 +is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor + +[Term] +id: GO:0140284 +name: endoplasmic reticulum-endosome membrane contact site +namespace: cellular_component +def: "A contact site between the endoplasmic reticulum membrane and the endosome membrane." [PMID:24105263, PMID:30220460] +synonym: "ER-endosome membrane contact site" EXACT [] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:0140285 +name: endosome fission +namespace: biological_process +def: "The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane." [PMID:25416943, PMID:30220460] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0140288 +name: GBAF complex +namespace: cellular_component +def: "A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM." [PMID:29374058] +is_a: GO:0070603 ! SWI/SNF superfamily-type complex + +[Term] +id: GO:0140289 +name: protein mono-ADP-ribosylation +namespace: biological_process +def: "The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids." [PMID:25043379] +is_a: GO:0006471 ! protein ADP-ribosylation + +[Term] +id: GO:0140290 +name: peptidyl-serine ADP-deribosylation +namespace: biological_process +def: "The removal of ADP-ribose from ADP-ribosylserine." [PMID:28650317, PMID:29234005] +is_a: GO:0051725 ! protein de-ADP-ribosylation + +[Term] +id: GO:0140291 +name: peptidyl-glutamate ADP-deribosylation +namespace: biological_process +def: "The removal of ADP-ribose from ADP-ribosylglutamate." [PMID:23481255] +is_a: GO:0051725 ! protein de-ADP-ribosylation + +[Term] +id: GO:0140292 +name: ADP-ribosylserine hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose." [PMID:28650317, PMID:29234005] +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0140293 +name: ADP-ribosylglutamate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose." [PMID:23481255] +is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds + +[Term] +id: GO:0140294 +name: NAD DNA ADP-ribosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA." [PMID:27471034, PMID:29361132, PMID:29520010] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:0140295 +name: pathogen-derived receptor ligand activity +namespace: molecular_function +def: "The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity." [PMID:20601497] +comment: Note that this term is meant to annotate effectors for which the evolved activity is to act as a ligand to activate (for necrotrophs) or suppress (for biotrophs) the host immune system. It should not be used to annotate PAMPs (pathogen-associated molecular pattern molecules) or similar types of microbial proteins recognized by the host innate immune system (for example, PAMPs are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals). PAMPs activate innate immune responses, protecting the host from infection, but this is not the molecular function of PAMPs; those usually form the structure of the bacterial cell wall. +synonym: "innate receptor ligand activity" RELATED [] +is_a: GO:0048018 ! receptor ligand activity + +[Term] +id: GO:0140296 +name: general transcription initiation factor binding +namespace: molecular_function +def: "Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation." [GOC:txnOH-2018] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0140297 +name: DNA-binding transcription factor binding +namespace: molecular_function +alt_id: GO:0001107 +alt_id: GO:0033613 +alt_id: GO:0070491 +def: "Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription." [GOC:txnOH-2018] +synonym: "activating transcription factor binding" RELATED [] +synonym: "repressing transcription factor binding" RELATED [] +synonym: "transcription activator binding" RELATED [] +is_a: GO:0008134 ! transcription factor binding + +[Term] +id: GO:0140298 +name: endocytic iron import into cell +namespace: biological_process +def: "Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis." [PMID:23092063] +synonym: "iron import into cell by endocytosis" EXACT [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0033212 ! iron import into cell + +[Term] +id: GO:0140299 +name: small molecule sensor activity +namespace: molecular_function +def: "Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:26328879] +subset: goslim_drosophila +subset: goslim_generic +synonym: "small molecular sensor activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140300 +name: serine import into mitochondrion +namespace: biological_process +def: "The process in which serine is transported from the cytosol into the mitochondrial matrix." [PMID:30442778] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0032329 ! serine transport +is_a: GO:0043090 ! amino acid import +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140301 +name: pollen-stigma interaction +namespace: biological_process +def: "The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae." [PMID:27899537] +is_a: GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0140302 +name: pollen-style interaction +namespace: biological_process +def: "The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte." [PMID:27899537] +is_a: GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:0140303 +name: intramembrane lipid transporter activity +namespace: molecular_function +def: "Enables the transport of a lipid from a region of a membrane to a different region on the same membrane." [PMID:16828084] +synonym: "flippase activity" RELATED [] +synonym: "translocase activity" BROAD [] +is_a: GO:0005319 ! lipid transporter activity + +[Term] +id: GO:0140306 +name: lipoprotein releasing activity +namespace: molecular_function +def: "The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex." [PMID:10783239, PMID:21670534] +is_a: GO:0140318 ! protein transporter activity + +[Term] +id: GO:0140311 +name: protein sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a specific protein, to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:1493333] +is_a: GO:0140313 ! molecular sequestering activity + +[Term] +id: GO:0140312 +name: cargo adaptor activity +namespace: molecular_function +alt_id: GO:0098748 +def: "Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery." [PMID:25795254] +synonym: "endocytic adaptor activity" NARROW [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0140313 +name: molecular sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a specific molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] +subset: goslim_drosophila +subset: goslim_generic +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140314 +name: calcium ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a calcium ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:13130076] +is_a: GO:0140487 ! metal ion sequestering activity + +[Term] +id: GO:0140315 +name: iron ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with an iron ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:27780864] +is_a: GO:0140487 ! metal ion sequestering activity + +[Term] +id: GO:0140316 +name: obsolete vesicular transport adaptor activity +namespace: molecular_function +def: "OBSOLETE. Binding directly to sorting signals in the cytosolic tails of transmembrane cargos (or transmembrane cargo receptors serving as recognition interfaces for lumenal cargos), to concentrate them into vesicles or tubules for transport via intracellular vesicular transport or the secretory pathway." [PMID:25795254] +comment: Thi sterm was obsoleted because it represented an unnecessary grouping class. +is_obsolete: true + +[Term] +id: GO:0140317 +name: export across cell outer membrane +namespace: biological_process +def: "The directed movement of a substance across the outer membrane in cells with two membranes." [PMID:15968039] +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:0140318 +name: protein transporter activity +namespace: molecular_function +def: "Directly binding to a specific protein and delivering it to a specific cellular location." [PMID:18706423] +comment: Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. +synonym: "protein carrier activity" RELATED [] +synonym: "protein transport chaperone" RELATED [] +xref: Reactome:R-HSA-9662747 "iRHOM2 transports ADAM17 from ER to the Golgi-network" +xref: Reactome:R-HSA-9662818 "iRHOM2 transports ADAM17:Zn2+ from Golgi to the plasma membrane" +is_a: GO:0005215 ! transporter activity + +[Term] +id: GO:0140319 +name: receptor decoy activity +namespace: molecular_function +alt_id: GO:0005040 +def: "Recognizing, binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor." [Wikipedia:Decoy_receptors] +synonym: "decoy death receptor activity" NARROW [] +synonym: "decoy receptor" EXACT [] +is_a: GO:0140313 ! molecular sequestering activity + +[Term] +id: GO:0140320 +name: PAMP receptor decoy activity +namespace: molecular_function +def: "A gene product which recognizes, binds and sequesters PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response." [PMID:20724636] +synonym: "pathogen-associated molecular pattern receptor decoy activity" EXACT [] +synonym: "pattern recognition receptor decoy activity" EXACT [] +is_a: GO:0140319 ! receptor decoy activity + +[Term] +id: GO:0140321 +name: negative regulation by symbiont of host autophagy +namespace: biological_process +def: "Any process in which a symbiont organism decreases the frequency, rate or extent of autophagy in the host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pg] +is_a: GO:0075071 ! modulation by symbiont of host autophagy +relationship: negatively_regulates GO:0006914 ! autophagy + +[Term] +id: GO:0140323 +name: solute:anion antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(in) + solute(out) = anion(out) + solute(in)." [GOC:pg] +is_a: GO:0008509 ! anion transmembrane transporter activity +is_a: GO:0015297 ! antiporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0140325 +name: negative regulation of protein localization to medial cortex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex." [PMID:30853434] +is_a: GO:0106011 ! regulation of protein localization to medial cortex +is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane +is_a: GO:1904777 ! negative regulation of protein localization to cell cortex +relationship: negatively_regulates GO:0071574 ! protein localization to medial cortex + +[Term] +id: GO:0140326 +name: ATPase-coupled intramembrane lipid transporter activity +namespace: molecular_function +alt_id: GO:0004012 +alt_id: GO:0008557 +def: "Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases." [PMID:16828084] +synonym: "aminophospholipid-transporting ATPase" RELATED [] +synonym: "ATPase-coupled phospholipid transporter activity" RELATED [] +synonym: "ATPase-dependent phospholipid transporter activity" RELATED [] +synonym: "phospholipid flippase activity" NARROW [] +synonym: "phospholipid translocating ATPase activity" RELATED [] +synonym: "phospholipid-translocating ATPase activity" RELATED [] +synonym: "phospholipid-transporting ATPase activity" RELATED [EC:7.6.2.1] +xref: EC:7.6.2.1 +xref: MetaCyc:3.6.3.1-RXN +xref: Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane" +xref: Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" +is_a: GO:0140303 ! intramembrane lipid transporter activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0140327 +name: flippase activity +namespace: molecular_function +def: "Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane). +synonym: "flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity + +[Term] +id: GO:0140328 +name: floppase activity +namespace: molecular_function +def: "Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:20043909, PMID:25284293, Wikipedia:Flippase] +comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaftlet of a membrane). +synonym: "floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +is_a: GO:0140326 ! ATPase-coupled intramembrane lipid transporter activity + +[Term] +id: GO:0140329 +name: lysophospholipid translocation +namespace: biological_process +def: "The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [PMID:15661733] +is_a: GO:0045332 ! phospholipid translocation +is_a: GO:0051977 ! lysophospholipid transport + +[Term] +id: GO:0140330 +name: xenobiotic detoxification by transmembrane export across the cell outer membrane +namespace: biological_process +def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane." [PMID:11948170] +is_a: GO:0046618 ! xenobiotic export +is_a: GO:0140317 ! export across cell outer membrane +relationship: part_of GO:0098754 ! detoxification + +[Term] +id: GO:0140331 +name: aminophospholipid translocation +namespace: biological_process +def: "The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [GOC:pg] +is_a: GO:0015917 ! aminophospholipid transport +is_a: GO:0045332 ! phospholipid translocation + +[Term] +id: GO:0140332 +name: lipopolysaccharide transfer activity +namespace: molecular_function +def: "Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:24639492] +synonym: "intermembrane lipopolysaccharide transfer activity" EXACT [] +synonym: "intermembrane lipopolysaccharide transporter activity" EXACT [] +synonym: "intermembrane LPS transporter activity" EXACT [] +synonym: "lipopolysaccharide carrier activity" EXACT [] +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0140333 +name: glycerophospholipid flippase activity +namespace: molecular_function +def: "Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:26212235] +synonym: "glycerophospholipid flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0140327 ! flippase activity + +[Term] +id: GO:0140334 +name: lipopolysaccharide localization to cell outer membrane +namespace: biological_process +def: "A process in which a lipopolysaccharide is transported to the cell outer membrane." [PMID:24639492] +synonym: "LPS localization to cell outer membrane" EXACT [] +is_a: GO:0010876 ! lipid localization +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:0140337 +name: diacylglyceride transfer activity +namespace: molecular_function +def: "Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] +synonym: "diacylglyceride carrier activity" EXACT [] +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0140338 +name: sphingomyelin transfer activity +namespace: molecular_function +alt_id: GO:0010175 +def: "Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:9132017] +synonym: "sphingomyelin carrier activity" EXACT [] +synonym: "sphingosine transmembrane transporter activity" BROAD [] +is_a: GO:0120014 ! phospholipid transfer activity +is_a: GO:0120016 ! sphingolipid transfer activity + +[Term] +id: GO:0140339 +name: phosphatidylglycerol transfer activity +namespace: molecular_function +def: "Directly binding to phosphatidylglycerol and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] +synonym: "phosphatidylglycerol carrier activity" EXACT [] +is_a: GO:0120014 ! phospholipid transfer activity + +[Term] +id: GO:0140340 +name: cerebroside transfer activity +namespace: molecular_function +def: "Directly binding to a cerebroside and delivering it either to an acceptor molecule or to a specific location." [PMID:9132017] +synonym: "cerebroside carrier activity" EXACT [] +is_a: GO:0017089 ! glycolipid transfer activity +is_a: GO:0120017 ! ceramide transfer activity + +[Term] +id: GO:0140341 +name: phosphatidylethanolamine floppase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylethanolamine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:10029989] +synonym: "phosphatidylethanolamine floppase activity (cytosolic to exoplasmic leaftlet)" EXACT [] +is_a: GO:0005548 ! phospholipid transporter activity +is_a: GO:0140328 ! floppase activity + +[Term] +id: GO:0140343 +name: phosphatidylserine transfer activity +namespace: molecular_function +def: "Removes phosphatidylserine from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." [PMID:26206935] +synonym: "intermembrane phosphatidylserine carrier activity" NARROW [] +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0140344 +name: triglyceride transfer activity +namespace: molecular_function +def: "Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location." [PMID:23475612] +synonym: "triglyceride carrier activity" EXACT [] +is_a: GO:0120013 ! lipid transfer activity + +[Term] +id: GO:0140345 +name: phosphatidylcholine flippase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854] +synonym: "phosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0008525 ! phosphatidylcholine transporter activity +is_a: GO:0140333 ! glycerophospholipid flippase activity + +[Term] +id: GO:0140346 +name: phosphatidylserine flippase activity +namespace: molecular_function +def: "Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:11870854] +synonym: "phosphatidylserine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0015247 ! aminophospholipid flippase activity +is_a: GO:0140333 ! glycerophospholipid flippase activity + +[Term] +id: GO:0140347 +name: N-retinylidene-phosphatidylethanolamine flippase activity +namespace: molecular_function +def: "Catalysis of the movement of N-retinylidene-N-retinylphosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:10412977] +synonym: "N-retinylidene-phosphatidylethanolamine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0140333 ! glycerophospholipid flippase activity + +[Term] +id: GO:0140348 +name: lysophosphatidylcholine flippase activity +namespace: molecular_function +def: "Catalysis of the movement of lysophosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." [PMID:26945070] +synonym: "lysophosphatidylcholine flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0140333 ! glycerophospholipid flippase activity + +[Term] +id: GO:0140351 +name: glycosylceramide flippase activity +namespace: molecular_function +def: "Catalysis of the movement of glycosylceramide from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Glycosylceramides are ceramides containing a functional group derived from a sugar." [PMID:30530492] +synonym: "galactocerebroside flippase activity" NARROW [] +synonym: "galactosylceramide flippase activity" NARROW [] +synonym: "glucosylceramide flippase activity" NARROW [] +synonym: "glycoceramide flippase activity" EXACT [] +synonym: "glycosylceramide flippase activity (exoplasmic to cytosolic leaftlet)" EXACT [] +is_a: GO:0046624 ! sphingolipid transporter activity +is_a: GO:0140327 ! flippase activity + +[Term] +id: GO:0140352 +name: export from cell +namespace: biological_process +def: "The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis." [GOC:pg] +synonym: "efflux" BROAD [] +is_a: GO:0006810 ! transport +is_a: GO:0009987 ! cellular process + +[Term] +id: GO:0140353 +name: lipid export from cell +namespace: biological_process +def: "The directed movement of a lipid from a cell, into the extracellular region." [GOC:pg] +synonym: "lipid efflux" BROAD [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0140352 ! export from cell + +[Term] +id: GO:0140354 +name: lipid import into cell +namespace: biological_process +def: "The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [GOC:pg] +synonym: "lipid uptake" BROAD [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0098657 ! import into cell + +[Term] +id: GO:0140355 +name: cargo receptor ligand activity +namespace: molecular_function +def: "The activity of a gene product that interacts with a cargo receptor and initiates endocytosis." [PMID:15797858] +synonym: "cargo" RELATED [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:0140357 +name: heme export from vacuole to cytoplasm +namespace: biological_process +def: "The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol." [PMID:28193844] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0035351 ! heme transmembrane transport +is_a: GO:0097037 ! heme export + +[Term] +id: GO:0140358 +name: P-type transmembrane transporter activity +namespace: molecular_function +def: "Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol." [PMID:18075584, PMID:25918123] +synonym: "E1-E2 ATPase" EXACT [Wikipedia:P-type_ATPase] +synonym: "P-type ATPase" EXACT [Wikipedia:P-type_ATPase] +xref: TC:3.A.3 +xref: Wikipedia:P-type_ATPase +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0140359 +name: ABC-type transporter activity +namespace: molecular_function +def: "Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane." [PMID:26517899] +synonym: "ABC transporter" EXACT [] +synonym: "ABC-type efflux permease activity" EXACT [] +synonym: "ABC-type efflux porter activity" EXACT [] +synonym: "ABC-type transmembrane transporter activity" EXACT [] +synonym: "ABC-type uptake permease activity" EXACT [] +synonym: "ATP binding cassette transporter" EXACT [] +synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] +synonym: "ATP-binding cassette transporter" EXACT [] +xref: Reactome:R-HSA-266070 "LTC4 is exported from the cytosol by ABCC1" +xref: Reactome:R-HSA-5223313 "ABCD4 may transport Cbl from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-5362459 "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol" +xref: Reactome:R-HSA-5387389 "Hh processing variants are translocated to the cytosol in a VCP-dependent manner" +xref: Reactome:R-HSA-5683325 "Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol" +xref: Reactome:R-HSA-9661405 "ABCC1 transports BIL from cytosol to extracellular region (blood)" +xref: TC:3.A.1 +xref: Wikipedia:ATP-binding_cassette_transporter +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity + +[Term] +id: GO:0140360 +name: cyclic-GMP-AMP transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other." [PMID:31126740] +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:0140361 +name: cyclic-GMP-AMP transmembrane import across plasma membrane +namespace: biological_process +def: "The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol." [PMID:31126740] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:0070729 ! cyclic nucleotide transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1903790 ! guanine nucleotide transmembrane transport + +[Term] +id: GO:0140363 +name: TIS granule +namespace: cellular_component +def: "A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER)." [PMID:30449617, PMID:30479375, Wikipedia:TIGER_domain] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0140364 +name: GW body +namespace: cellular_component +def: "A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs." [PMID:16418578, PMID:26930655, PMID:29576456] +synonym: "GW-body" EXACT [] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0140365 +name: RNP body +namespace: cellular_component +def: "A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules." [PMID:30197298] +synonym: "BR-body" EXACT [] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule + +[Term] +id: GO:0140366 +name: galectin lattice +namespace: cellular_component +def: "A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids." [PMID:19021578, PMID:26092931, PMID:28893908, PMID:30951647] +is_a: GO:0098635 ! protein complex involved in cell-cell adhesion + +[Term] +id: GO:0140367 +name: antibacterial innate immune response +namespace: biological_process +def: "An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:16177355, PMID:23006328] +is_a: GO:0042742 ! defense response to bacterium +is_a: GO:0045087 ! innate immune response + +[Term] +id: GO:0140368 +name: decoy receptor complex +namespace: cellular_component +def: "A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound." [GOC:bhm, PMID:30621730, PMID:9168977] +synonym: "osteoclastogenesis inhibitory factor" NARROW [] +synonym: "osteoprotegerin complex" NARROW [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:0140372 +name: histone H3 ubiquitination +namespace: biological_process +def: "The modification of histone H3 by the addition of one or more ubiquitin groups." [GOC:mah, PMID:31468675] +synonym: "histone H3 ubiquitylation" EXACT [] +is_a: GO:0016574 ! histone ubiquitination + +[Term] +id: GO:0140373 +name: histone H3-K14 ubiquitination +namespace: biological_process +def: "The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone." [GOC:mah, PMID:31468675] +synonym: "histone H3 ubiquitination at K14" EXACT [] +synonym: "histone H3-K14 ubiquitylation" EXACT [] +synonym: "histone H3K14 ubiquitination" EXACT [] +is_a: GO:0140372 ! histone H3 ubiquitination + +[Term] +id: GO:0140374 +name: antiviral innate immune response +namespace: biological_process +def: "A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens." [PMID:31006531] +is_a: GO:0045087 ! innate immune response +is_a: GO:0051607 ! defense response to virus + +[Term] +id: GO:0140375 +name: immune receptor activity +namespace: molecular_function +def: "Receiving a signal and transmitting it in a cell to initiate an immune response." [PMID:31415752, Wikipedia:Immune_receptor] +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:0140376 +name: innate immune receptor activity +namespace: molecular_function +def: "Receiving a signal and transmitting it in a cell to initiate an innate immune response." [PMID:28921463, PMID:31415752] +is_a: GO:0140375 ! immune receptor activity + +[Term] +id: GO:0140380 +name: psilocybin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product." [PMID:28763571] +is_a: GO:0006568 ! tryptophan metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process + +[Term] +id: GO:0140381 +name: 4-hydroxytryptamine 4-phosphate methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin." [PMID:28763571] +synonym: "norbaeocystin methyltransferase" EXACT [] +synonym: "psilocybin synthase" EXACT [] +xref: EC:2.1.1.345 +xref: RHEA:55568 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:0140382 +name: tryptamine 4-monooxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: tryptamine + reduced acceptor + O(2) <=> 4-hydroxytryptamine + acceptor + H(2)O." [PMID:28763571] +xref: EC:1.14.99.59 +xref: RHEA:15865 +is_a: GO:0004497 ! monooxygenase activity + +[Term] +id: GO:0140383 +name: 4-hydroxytryptamine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+)." [PMID:28763571] +xref: EC:2.7.1.222 +xref: RHEA:55564 +is_a: GO:0016301 ! kinase activity + +[Term] +id: GO:0140384 +name: metacyclogenesis +namespace: biological_process +def: "The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania." [PMID:12152483, PMID:21514274, PMID:2659372, PMID:29091711, PMID:29409544] +is_a: GO:0044114 ! development of symbiont in host + +[Term] +id: GO:0140393 +name: norsolorinic acid ketoreductase activity +namespace: molecular_function +def: "Catalysis of the reaction: (1'S)-averantin + NADP(+) <=> norsolorinic acid + NADPH." [PMID:10584035, PMID:8368836, RHEA:35447] +xref: EC:1.1.1.349 +xref: KEGG_REACTION:R10309 +xref: MetaCyc:RXN-9480 +xref: RHEA:35447 +is_a: GO:0045703 ! ketoreductase activity + +[Term] +id: GO:0140394 +name: ABC-type azole transporter activity +namespace: molecular_function +def: "Enables the transfer of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other according to the reaction: ATP + H2O + azole(in) = ADP + phosphate + azole(out)." [PMID:31501141, RHEA:33503] +synonym: "ATPase-coupled azole transmembrane transporter activity" RELATED [] +synonym: "azole ABC transporter activity" EXACT [] +xref: RHEA:33503 +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:0140395 +name: averantin hydroxylase activity +namespace: molecular_function +def: "Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O. Involved in aflatoxin biosynthesis." [EC:1.14.14.116, PMID:8368836] +xref: EC:1.14.14.116 +xref: MetaCyc:RXN-9482 +xref: RHEA:35575 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen + +[Term] +id: GO:0140396 +name: 5'-hydroxyaverantin dehydrogenase activity +namespace: molecular_function +def: "Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD(+) <=> 5'-oxoaverantin + NADH." [EC:1.1.1.352, PMID:14602595] +xref: EC:1.1.1.352 +xref: RHEA:35475 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0140397 +name: versiconal hemiacetal acetate esterase activity +namespace: molecular_function +def: "Catalyzes the reactions: versiconal hemiacetal acetate + H(2)O <=> versiconal + acetate, as well as versiconol acetate + H(2)O <=> versiconol + acetate." [EC:3.1.1.94, PMID:15006741, PMID:15932995, PMID:8368837] +xref: EC:3.1.1.94 +xref: MetaCyc:RXN-9488 +xref: MetaCyc:RXN-9493 +xref: RHEA:35715 +is_a: GO:0016788 ! hydrolase activity, acting on ester bonds + +[Term] +id: GO:0140398 +name: versicolorin B desaturase activity +namespace: molecular_function +def: "Catalyzes the reaction: versicolorin B + NADPH + O(2) <=> versicolorin A + NADP(+) + 2 H(2)O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus." [PMID:15006741, PMID:8368837] +xref: KEGG_REACTION:R10479 +xref: MetaCyc:RXN-9495 +xref: RHEA:35743 +is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water + +[Term] +id: GO:0140399 +name: aflatoxin B synthase activity +namespace: molecular_function +def: "Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H(2)O + methanol + CO(2). Produces both aflatoxin B(1) and aflatoxin B(2)." [EC:1.14.14.117] +xref: EC:1.14.14.117 +xref: MetaCyc:RXN-9497 +xref: MetaCyc:RXN-9502 +xref: RHEA:35759 +is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen + +[Term] +id: GO:0140403 +name: effector-mediated suppression of host innate immune response +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214, PMID:30584105] +synonym: "effector dependent suppression of host immune innate response by symbiont" EXACT [] +synonym: "effector triggered suppression of host immune innate response by symbiont" EXACT [] +synonym: "effector-dependent suppression of host immune innate response by symbiont" EXACT [] +synonym: "effector-mediated suppression of host immune innate response by symbiont" EXACT [] +synonym: "effector-mediated suppression of host innate immune response by symbiont" EXACT [] +synonym: "effector-mediated suppression of host innate immunity" EXACT [] +synonym: "effector-triggered suppression of host immune innate response by symbiont" EXACT [] +is_a: GO:0052170 ! suppression by symbiont of host innate immune response +is_a: GO:0140404 ! effector-mediated modulation of host innate immune response by symbiont +is_a: GO:0140590 ! effector-mediated suppression of host defenses + +[Term] +id: GO:0140404 +name: effector-mediated modulation of host innate immune response by symbiont +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214] +synonym: "effector mediated modulation of host immune response by symbiont" EXACT [] +synonym: "effector triggered modulation of host immune response by symbiont" EXACT [] +synonym: "effector-dependent modulation of host immune response by symbiont" EXACT [] +synonym: "effector-mediated modulation of host immunity" EXACT [] +synonym: "effector-triggered modulation of host immune response by symbiont" EXACT [] +is_a: GO:0052167 ! modulation by symbiont of host innate immune response +is_a: GO:0140415 ! effector-mediated modulation of host defenses by symbiont + +[Term] +id: GO:0140405 +name: spindle pole body-led chromosome movement during mitotic interphase +namespace: biological_process +def: "A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase." [PMID:31483748] +is_a: GO:0007018 ! microtubule-based movement +is_a: GO:0051303 ! establishment of chromosome localization + +[Term] +id: GO:0140406 +name: L-alanine export across the plasma membrane +namespace: biological_process +def: "The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region." [PMID:26073055, PMID:31591285] +is_a: GO:0032973 ! amino acid export across plasma membrane +is_a: GO:1904557 ! L-alanine transmembrane transport + +[Term] +id: GO:0140407 +name: L-alanine:proton antiporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)." [PMID:26073055, PMID:31591285] +is_a: GO:0015180 ! L-alanine transmembrane transporter activity +is_a: GO:0015299 ! solute:proton antiporter activity +is_a: GO:0015491 ! cation:cation antiporter activity + +[Term] +id: GO:0140408 +name: regulation of mRNA alternative polyadenylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755] +is_a: GO:1900363 ! regulation of mRNA polyadenylation +relationship: regulates GO:0110104 ! mRNA alternative polyadenylation + +[Term] +id: GO:0140409 +name: positive regulation of mRNA alternative polyadenylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation." [PMID:29507755] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:0140408 ! regulation of mRNA alternative polyadenylation +relationship: positively_regulates GO:0110104 ! mRNA alternative polyadenylation + +[Term] +id: GO:0140410 +name: solute:bicarbonate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + HCO3-(out) = solute(in) + HCO3-(in)." [PMID:27166256] +is_a: GO:0015106 ! bicarbonate transmembrane transporter activity +is_a: GO:0015293 ! symporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity + +[Term] +id: GO:0140412 +name: zinc:bicarbonate symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) = zinc(in) + HCO3-(in)." [PMID:27166256] +is_a: GO:0015294 ! solute:cation symporter activity +is_a: GO:0046915 ! transition metal ion transmembrane transporter activity +is_a: GO:0140410 ! solute:bicarbonate symporter activity + +[Term] +id: GO:0140413 +name: zinc:bicarbonate:selenite symporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: zinc(out) + HCO3-(out) + HO3Se-(out) = zinc(in) + HCO3-(in) + HO3Se-(out)." [PMID:27166256] +is_a: GO:0015296 ! anion:cation symporter activity +is_a: GO:0140412 ! zinc:bicarbonate symporter activity + +[Term] +id: GO:0140414 +name: phosphopantetheine-dependent carrier activity +namespace: molecular_function +def: "Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate." [PMID:17502372] +synonym: "carrier protein activity" EXACT [] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0140415 +name: effector-mediated modulation of host defenses by symbiont +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:30610168] +is_a: GO:0052200 ! response to host defenses +is_a: GO:0140418 ! effector-mediated modulation of host process by symbiont + +[Term] +id: GO:0140416 +name: transcription regulator inhibitor activity +namespace: molecular_function +def: "A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification." [PMID:10652346] +comment: Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA. +synonym: "DNA-binding transcription factor inhibitor activity" NARROW [] +is_a: GO:0140678 ! molecular function inhibitor activity + +[Term] +id: GO:0140417 +name: ATP-sensitive calcium-release channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts." [PMID:22736763] +is_a: GO:0015278 ! calcium-release channel activity + +[Term] +id: GO:0140418 +name: effector-mediated modulation of host process by symbiont +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21467214] +synonym: "effector mediated modulation of host process by symbiont" EXACT [] +synonym: "effector triggered modulation of host process by symbiont" EXACT [] +synonym: "effector-dependent modulation of host process by symbiont" EXACT [] +is_a: GO:0044003 ! modulation by symbiont of host process + +[Term] +id: GO:0140420 +name: heme import into cell +namespace: biological_process +def: "The directed movement of a heme from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis." [PMID:28193844] +synonym: "heme assimilation" BROAD [] +is_a: GO:0015886 ! heme transport +is_a: GO:0033212 ! iron import into cell + +[Term] +id: GO:0140421 +name: endocytic heme import into cell +namespace: biological_process +def: "The directed movement into cell of externally available heme by receptor-mediated endocytosis." [PMID:28193844] +synonym: "heme assimilation" BROAD [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0140420 ! heme import into cell + +[Term] +id: GO:0140423 +name: effector-mediated suppression of host pattern-triggered immunity signaling +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants." [PMID:30584105] +synonym: "effector-mediated suppression of host pattern recognition receptor signaling" BROAD [] +synonym: "effector-mediated suppression of host PRR signaling" BROAD [] +synonym: "effector-mediated suppression of host PRR signalling" BROAD [] +synonym: "effector-mediated suppression of pattern-triggered immunity signaling" EXACT [] +synonym: "effector-mediated suppression of PTI signalling" EXACT [] +is_a: GO:0052034 ! effector-mediated suppression of host pattern-triggered immunity + +[Term] +id: GO:0140425 +name: galactose import across plasma membrane +namespace: biological_process +def: "The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:23254763] +is_a: GO:0015757 ! galactose transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:0140426 +name: PAMP-triggered immunity signalling pathway +namespace: biological_process +def: "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species." [PMID:25744358] +synonym: "MAMP-triggered immunity signalling" EXACT [] +synonym: "pathogen-associated molecular pattern signalling" EXACT [] +synonym: "PTI signalling" EXACT [] +is_a: GO:0002221 ! pattern recognition receptor signaling pathway +is_a: GO:0002758 ! innate immune response-activating signal transduction + +[Term] +id: GO:0140429 +name: positive regulation of mitotic sister chromatid biorientation +namespace: biological_process +alt_id: GO:0098783 +alt_id: GO:1990598 +def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536, PMID:20739936, PMID:21306900] +synonym: "correction of merotelic kinetochore attachment, mitotic" NARROW [] +synonym: "correction of mono-orientation defects" NARROW [] +synonym: "correction of syntelic kinetochore attachment, mitotic" NARROW [GOC:vw] +synonym: "repair of mitotic merotelic kinetochore attachment defect" NARROW [] +synonym: "repair of mitotic merotelic kinetochore attachment defects" NARROW [] +synonym: "repair of mitotic mono-orientation defect" NARROW [] +synonym: "repair of mitotic mono-orientation defects" NARROW [] +is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling +is_a: GO:0140273 ! repair of mitotic kinetochore microtubule attachment defect +is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore +relationship: positively_regulates GO:1990758 ! mitotic sister chromatid biorientation + +[Term] +id: GO:0140430 +name: positive regulation of chromosome passenger complex localization to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore." [PMID:20739936] +is_a: GO:1905342 ! positive regulation of protein localization to kinetochore +relationship: positively_regulates GO:0072356 ! chromosome passenger complex localization to kinetochore + +[Term] +id: GO:0140431 +name: DNA-(abasic site) binding +namespace: molecular_function +def: "Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base." [PMID:23245849] +synonym: "DNA AP site binding" EXACT [] +synonym: "DNA-(apurinic site) binding" NARROW [] +synonym: "DNA-(apurinic site/apyrimidinic site) binding" EXACT [] +synonym: "DNA-(apyrimidinic site) binding" NARROW [] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:0140432 +name: 5'-hydroxyl dinucleotide hydrolase +namespace: molecular_function +def: "Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA." [PMID:31777937] +is_a: GO:0004540 ! ribonuclease activity + +[Term] +id: GO:0140433 +name: regulation of protein localization to meiotic spindle pole body +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:1902363 ! regulation of protein localization to spindle pole body +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:1902441 ! protein localization to meiotic spindle pole body + +[Term] +id: GO:0140434 +name: positive regulation of protein localization to meiotic spindle pole body +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0140433 ! regulation of protein localization to meiotic spindle pole body +is_a: GO:1902365 ! positive regulation of protein localization to spindle pole body +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:1902441 ! protein localization to meiotic spindle pole body + +[Term] +id: GO:0140435 +name: negative regulation of protein localization to meiotic spindle pole body +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body." [PMID:22438582] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0140433 ! regulation of protein localization to meiotic spindle pole body +is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:1902441 ! protein localization to meiotic spindle pole body + +[Term] +id: GO:0140438 +name: protein stearoylation +namespace: biological_process +def: "The covalent attachment of a stearoyl group to an amino acid in a protein." [PMID:26214738] +is_a: GO:0006497 ! protein lipidation + +[Term] +id: GO:0140439 +name: protein-cysteine S-stearoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]." [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740] +xref: RHEA:59740 +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0140440 +name: protein-cysteine S-oleoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]." [PMID:22247542, RHEA:59744] +xref: RHEA:59744 +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0140441 +name: protein-cysteine S-arachidonoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]." [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59748] +xref: RHEA:59748 +is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity + +[Term] +id: GO:0140442 +name: peroxide sensor activity +namespace: molecular_function +def: "Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule." [PMID:20919928] +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0140443 +name: mitochondrion-plasma membrane adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:31582398] +synonym: "mitochondrion plasma membrane adaptor activity" EXACT [] +synonym: "mitochondrion plasma membrane tether activity" EXACT [] +synonym: "plasma membrane-mitochondrion adaptor activity" EXACT [] +synonym: "plasma membrane-mitochondrion tether activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140444 +name: cytoskeleton-nuclear membrane anchor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane." [PMID:16237665] +synonym: "cytoskeletal protein-nuclear membrane adaptor activity" EXACT [] +synonym: "cytoskeletal protein-nuclear membrane anchor activity" EXACT [] +synonym: "cytoskeleton nuclear membrane anchor activity" EXACT [] +synonym: "nuclear membrane-cytoskeleton anchor activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140445 +name: chromosome, telomeric repeat region +namespace: cellular_component +def: "A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop." [PMID:11352055, PMID:30208292] +is_a: GO:0000781 ! chromosome, telomeric region + +[Term] +id: GO:0140446 +name: fumigermin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus." [PMID:32083553] +synonym: "fumigermin anabolism" EXACT [] +synonym: "fumigermin biosynthesis" EXACT [] +synonym: "fumigermin formation" EXACT [] +synonym: "fumigermin synthesis" EXACT [] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:0140447 +name: cytokine precursor processing +namespace: biological_process +def: "The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine." [PMID:29247995] +synonym: "interleukin maturation" NARROW [] +synonym: "interleukin processing" NARROW [] +is_a: GO:0140448 ! signaling receptor ligand precursor processing +relationship: part_of GO:0001816 ! cytokine production + +[Term] +id: GO:0140448 +name: signaling receptor ligand precursor processing +namespace: biological_process +alt_id: GO:0035638 +def: "The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand." [PMID:29247995] +synonym: "ligand maturation" NARROW [GOC:bf] +synonym: "signal maturation" RELATED [] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:0140449 +name: centromere-nuclear envelope anchor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location." [PMID:31635174] +synonym: "centromere nuclear envelope anchor activity" EXACT [] +synonym: "centromere nuclear envelope tether activity" EXACT [] +synonym: "centromere-inner nuclear envelope anchor activity" EXACT [] +synonym: "centromere-inner nuclear envelope tether activity" EXACT [] +synonym: "chromosome, centromeric region-nuclear envelope anchor activity" EXACT [] +synonym: "nuclear envelope-centromere anchor activity" EXACT [] +synonym: "nuclear envelope-centromere tether activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140450 +name: protein targeting to Golgi apparatus +namespace: biological_process +def: "The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation)." [PMID:18817523] +is_a: GO:0006605 ! protein targeting +is_a: GO:0034067 ! protein localization to Golgi apparatus +is_a: GO:0072594 ! establishment of protein localization to organelle + +[Term] +id: GO:0140451 +name: counting factor complex +namespace: cellular_component +def: "A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum." [PMID:10444594, PMID:12117815, PMID:12912898, PMID:16963635, PMID:18426773] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0140453 +name: protein aggregate center +namespace: cellular_component +def: "Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773] +synonym: "PAC" BROAD [] +synonym: "protein aggregate centre" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0140454 +name: protein aggregate center assembly +namespace: biological_process +def: "The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773] +synonym: "PAC assembly" BROAD [] +synonym: "protein aggregate center formation" EXACT [] +synonym: "protein aggregate centre assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0140455 +name: cytoplasm protein quality control +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding." [PMID:32075773] +is_a: GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins + +[Term] +id: GO:0140456 +name: initial meiotic spindle pole body separation +namespace: biological_process +def: "The release of duplicated meiotic spindle pole bodies (SPBs)." [PMID:31532702] +synonym: "initial spindle pole body separation involved in meiosis I" EXACT [] +synonym: "meiotic spindle pole body duplication" EXACT [] +is_a: GO:0110100 ! spindle pole body separation +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:0140457 +name: protein demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a protein." [PMID:24498420, PMID:28360925] +is_a: GO:0032451 ! demethylase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0140458 +name: pre-transcriptional gene silencing by RNA +namespace: biological_process +def: "Any gene inactivation (silencing) process mediated by small RNA molecules that occur before the trancription begins." [PMID:21420348] +is_a: GO:0031047 ! gene silencing by RNA +is_a: GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0140459 +name: response to Gram-positive bacterium +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium." [PMID:23664307] +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0140460 +name: response to Gram-negative bacterium +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium." [PMID:23664307] +is_a: GO:0009617 ! response to bacterium + +[Term] +id: GO:0140461 +name: obsolete subtelomeric heterochromatin organization +namespace: biological_process +def: "OBSOLETE. The organization of chromatin into heterochromatin at the subtelomeric region of a chromosome." [PMID:26744419] +comment: This term has been obsoleted because it represents a different process, GO:0097240 attachment of telomeric heterochromatin to nuclear envelope. +is_obsolete: true + +[Term] +id: GO:0140462 +name: pericentric heterochromatin organization +namespace: biological_process +def: "The organization of chromatin into heterochromatin at the pericentric region of a chromosome." [PMID:26744419] +is_a: GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0140463 +name: chromatin-protein adaptor +namespace: molecular_function +def: "The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex." [PMID:32277274] +synonym: "chromatin adaptor" EXACT [] +synonym: "chromatin adaptor activity" EXACT [] +synonym: "chromatin receptor" EXACT [] +synonym: "chromatin recruitment" RELATED [] +synonym: "protein-chromatin adaptor activity" EXACT [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0140464 +name: silent mating-type cassette heterochromatin organization +namespace: biological_process +def: "The organization of chromatin into heterochromatin at a silent mating-type cassette locus." [PMID:26744419] +is_a: GO:0070828 ! heterochromatin organization + +[Term] +id: GO:0140466 +name: iron-sulfur cluster export from the mitochondrion +namespace: biological_process +def: "The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane." [PMID:31040179] +is_a: GO:1902497 ! iron-sulfur cluster transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140467 +name: integrated stress response signaling +namespace: biological_process +def: "The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery." [PMID:27629041] +synonym: "ISR" RELATED [] +xref: Wikipedia:Integrated_stress_response +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:0140468 +name: HRI-mediated signaling +namespace: biological_process +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock." [PMID:27629041] +synonym: "EIF2AK1-mediated signaling" EXACT [] +is_a: GO:0140467 ! integrated stress response signaling + +[Term] +id: GO:0140469 +name: GCN2-mediated signaling +namespace: biological_process +alt_id: GO:0060733 +def: "A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation." [PMID:27629041] +synonym: "EIF2AK4-mediated signaling" EXACT [] +synonym: "regulation of eIF2 alpha phosphorylation by amino acid starvation" NARROW [] +is_a: GO:0140467 ! integrated stress response signaling + +[Term] +id: GO:0140471 +name: positive regulation of transepithelial migration of symbiont in host +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transepithelial migration of symbiont in host." [PMID:29113016] +synonym: "positive regulation of transmigration of symbiont in host" RELATED [] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0035756 ! transepithelial migration of symbiont in host + +[Term] +id: GO:0140472 +name: cell cortex of non-growing cell tip +namespace: cellular_component +def: "The region directly beneath the plasma membrane at the cell tip at which no growth takes place." [PMID:17895368] +is_a: GO:0051285 ! cell cortex of cell tip +relationship: part_of GO:0035839 ! non-growing cell tip + +[Term] +id: GO:0140473 +name: telomere-nuclear envelope anchor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location." [PMID:31635174] +synonym: "nuclear envelope-telomere anchor activity" EXACT [] +synonym: "telomere-nuclear envelope anchoring activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140474 +name: mitochondrion-endoplasmic reticulum membrane tether activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion." [PMID:19556461, PMID:27875684] +synonym: "endoplasmic reticulum-mitochondrion membrane adaptor activity" EXACT [] +synonym: "endoplasmic reticulum-mitochondrion membrane tether activity" EXACT [] +synonym: "ER-mitochondrion membrane adaptor activity" EXACT [] +synonym: "ER-mitochondrion membrane tether activity" EXACT [] +synonym: "mitochondrion-endoplasmic reticulum membrane adaptor activity" EXACT [] +synonym: "mitochondrion-ER membrane adaptor activity" EXACT [] +synonym: "mitochondrion-ER membrane tether activity" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140475 +name: spindle pole body anchor activity +namespace: molecular_function +def: "The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way." [PMID:19942852] +is_a: GO:0008093 ! cytoskeletal anchor activity + +[Term] +id: GO:0140479 +name: ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase +namespace: biological_process +def: "A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide." [PMID:22209968, PMID:24828577] +is_a: GO:0052699 ! ergothioneine biosynthetic process + +[Term] +id: GO:0140480 +name: mitotic spindle pole body insertion into the nuclear envelope +namespace: biological_process +def: "A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane." [PMID:19487457, PMID:24529240] +synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [] +synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT [] +synonym: "establishment of spindle pole body localization to nuclear envelope" EXACT [] +is_a: GO:1990608 ! mitotic spindle pole body localization + +[Term] +id: GO:0140481 +name: ABC-type iron-sulfur cluster transporter activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O + iron-sulfur cluster(in) = ADP + phosphate + iron-sulfur cluster(out)." [PMID:31040179] +synonym: "ATPase-coupled Fe-S cluster transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled iron-sulfur cluster transmembrane transporter activity" RELATED [] +xref: TC:3.A.1.210.1 +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0140482 +name: iron sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron." [PMID:11956219, PMID:25806539] +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0140483 +name: kinetochore adaptor activity +namespace: molecular_function +def: "The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way." [PMID:22521786] +synonym: "inner kinetochore adaptor activity" NARROW [] +synonym: "outer kinetochore adaptor activity" NARROW [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0140484 +name: 5-aminolevulinic acid import across plasma membrane +namespace: biological_process +def: "The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol." [PMID:31989647] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:0140485 +name: 5-aminolevulinic acid transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other." [PMID:31989647, RHEA:64816] +xref: RHEA:64816 +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015171 ! amino acid transmembrane transporter activity + +[Term] +id: GO:0140486 +name: zinc ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a zinc ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156] +is_a: GO:0140487 ! metal ion sequestering activity + +[Term] +id: GO:0140487 +name: metal ion sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a metal ion to prevent it from interacting with sensitive components of a biological system." [PMID:12050156] +is_a: GO:0140313 ! molecular sequestering activity + +[Term] +id: GO:0140488 +name: heme receptor activity +namespace: molecular_function +def: "Binding specifically to heme to deliver it to a transport vesicle." [PMID:28193844, PMID:32185489] +is_a: GO:0038024 ! cargo receptor activity + +[Term] +id: GO:0140489 +name: molecular template activity +namespace: molecular_function +def: "The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence." [GOC:pg] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140490 +name: microtubule nucleator activity +namespace: molecular_function +def: "The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly." [PMID:20631709, PMID:21993292] +synonym: "microtubule nucleation template activity" EXACT [] +is_a: GO:0140489 ! molecular template activity + +[Term] +id: GO:0140491 +name: ubiquitin-like hydrolase activity +namespace: molecular_function +def: "An activity that cleaves ubiquitin or ubiquitin-like proteins (ULP) from target proteins." [PMID:19489724] +synonym: "ubiquitinyl-like hydrolase activity" EXACT [] +is_a: GO:0008233 ! peptidase activity + +[Term] +id: GO:0140492 +name: metal-dependent deubiquitinase activity +namespace: molecular_function +def: "Catalysis of the metal-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [PMID:19489724] +synonym: "metal-dependent ubiquitin-like hydrolase activity" EXACT [] +synonym: "metal-dependent ubiquitinyl-like hydrolase activity" EXACT [] +is_a: GO:0008237 ! metallopeptidase activity +is_a: GO:0101005 ! deubiquitinase activity + +[Term] +id: GO:0140493 +name: very long-chain fatty acid beta-oxidation +namespace: biological_process +def: "A fatty acid beta-oxidation pathway acting on fatty acid which has a chain length greater than C22 in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:ha, PMID:17028011, PMID:32169171] +is_a: GO:0033540 ! fatty acid beta-oxidation using acyl-CoA oxidase +is_a: GO:0042760 ! very long-chain fatty acid catabolic process + +[Term] +id: GO:0140494 +name: migrasome +namespace: cellular_component +def: "A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration." [PMID:25342562, PMID:31371827] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:0140495 +name: migracytosis +namespace: biological_process +def: "A cell migration-dependent mechanism for releasing cellular contents." [PMID:25342562] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:0140496 +name: gamma-tubulin complex binding +namespace: molecular_function +def: "Binding to a gamma-tubulin complex." [PMID:30174135] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:0140497 +name: mannan polymerase II complex +namespace: cellular_component +def: "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p." [PMID:9430634] +is_a: GO:0000136 ! mannan polymerase complex + +[Term] +id: GO:0140498 +name: mannan polymerase I complex +namespace: cellular_component +def: "A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p." [PMID:9430634] +is_a: GO:0000136 ! mannan polymerase complex + +[Term] +id: GO:0140499 +name: negative regulation of mitotic spindle assembly checkpoint signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling." [PMID:28017606] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition +is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation +is_a: GO:0090233 ! negative regulation of spindle checkpoint +is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint +relationship: negatively_regulates GO:0007094 ! mitotic spindle assembly checkpoint signaling + +[Term] +id: GO:0140500 +name: regulation of reticulophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reticulophagy." [PMID:32735772] +synonym: "regulation of autophagy of the endoplasmic reticulum" EXACT [] +synonym: "regulation of autophagy of the ER" EXACT [] +synonym: "regulation of endoplasmic reticulum autophagy" EXACT [] +synonym: "regulation of endoplasmic reticulum degradation" RELATED [] +synonym: "regulation of ER autophagy" EXACT [] +synonym: "regulation of ER degradation" RELATED [] +synonym: "regulation of ER-phagy" EXACT [] +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0061709 ! reticulophagy + +[Term] +id: GO:0140501 +name: positive regulation of reticulophagy +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of reticulophagy." [PMID:32735772] +synonym: "positive regulation of autophagy of the endoplasmic reticulum" EXACT [] +synonym: "positive regulation of autophagy of the ER" EXACT [] +synonym: "positive regulation of endoplasmic reticulum autophagy" EXACT [] +synonym: "positive regulation of endoplasmic reticulum degradation" RELATED [] +synonym: "positive regulation of ER autophagy" EXACT [] +synonym: "positive regulation of ER degradation" RELATED [] +synonym: "positive regulation of ER-phagy" EXACT [] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:0140500 ! regulation of reticulophagy +relationship: positively_regulates GO:0061709 ! reticulophagy + +[Term] +id: GO:0140502 +name: effector-mediated suppression of host salicylic acid-mediated innate immune signalling +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signalling." [PMID:25438793, PMID:30651637] +is_a: GO:0052003 ! suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway +is_a: GO:0140404 ! effector-mediated modulation of host innate immune response by symbiont + +[Term] +id: GO:0140504 +name: microlipophagy +namespace: biological_process +def: "Microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion, such as during the transition to stationary phase or in response to nutrient limitation. Microlipophagy is mediated by the formation of sterol-enriched vacuolar microdomains at sites of engulfment. Initiation of microautophagy is defined as the point where liquid-ordered microdomains are formed at sites of engulfment, that requires S. cerevisiae Atg32p and Atg21p, as well as Niemann-Pick type C (NPC) sterol transporter proteins, Ncr1p and Npc2p. This is followed by redistribution of Atg14p from ER exit sites onto liquid-ordered vacuole membrane domains through interaction with stabilized AMP-activated protein kinase (AMPK), and together with Atg6p facilities docking and internalization of lipid droplets (LDs) at sites of invagination." [PMID:25070953, PMID:28394250, PMID:28838958, PMID:29293450, PMID:29601311] +synonym: "lipid droplet autophagy" EXACT [PMID:29293450] +is_a: GO:0016237 ! lysosomal microautophagy + +[Term] +id: GO:0140505 +name: regulation of microlipophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion." [PMID:28394250, PMID:29601311] +is_a: GO:0010506 ! regulation of autophagy +relationship: regulates GO:0140504 ! microlipophagy + +[Term] +id: GO:0140506 +name: endoplasmic reticulum-autophagosome adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy." [PMID:32735772] +synonym: "autophagosome-endoplasmic reticulum anchor" EXACT [] +synonym: "autophagosome-ER anchor" EXACT [] +synonym: "ER- autophagosome anchor" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140507 +name: granzyme-mediated programmed cell death signaling pathway +namespace: biological_process +def: "A series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells." [PMID:32299851] +synonym: "granzyme-mediated cell death signaling pathway" BROAD [] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0012501 ! programmed cell death + +[Term] +id: GO:0140509 +name: epithelium-like organization +namespace: biological_process +def: "The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins." [PMID:21393547, PMID:22902739] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:0140510 +name: mitotic nuclear bridge +namespace: cellular_component +def: "A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei." [PMID:32848252] +synonym: "nuclear bridge" BROAD [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0140511 +name: mitotic nuclear bridge stalk +namespace: cellular_component +def: "Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes." [PMID:32848252] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0140510 ! mitotic nuclear bridge + +[Term] +id: GO:0140512 +name: mitotic nuclear bridge midzone +namespace: cellular_component +def: "The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei." [PMID:32848252] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0140510 ! mitotic nuclear bridge + +[Term] +id: GO:0140513 +name: nuclear protein-containing complex +namespace: cellular_component +def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus." [GOC:pg] +subset: gocheck_do_not_annotate +synonym: "nuclear complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005634 ! nucleus + +[Term] +id: GO:0140515 +name: mitotic nuclear bridge organization +namespace: biological_process +def: "A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis." [PMID:32848252] +is_a: GO:0101024 ! mitotic nuclear membrane organization + +[Term] +id: GO:0140516 +name: mitotic nuclear pore complex disassembly +namespace: biological_process +def: "The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis." [PMID:32848252] +synonym: "nuclear pore complex disassembly during mitosis" EXACT [] +is_a: GO:0006999 ! nuclear pore organization +is_a: GO:0007077 ! mitotic nuclear membrane disassembly +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:0140517 +name: protein-RNA adaptor activity +namespace: molecular_function +def: "The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way." [PMID:24470144] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0140522 +name: fusogenic activity +namespace: molecular_function +def: "The activity of joining two lipid bilayers to form a single membrane." [PMID:10332732, PMID:11493675, PMID:12600315, PMID:32100701, PMID:32641474] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140523 +name: GTPase-dependent fusogenic activity +namespace: molecular_function +def: "A GTPase activity that mediates the joining two lipid bilayers to form a single membrane." [PMID:29663589] +synonym: "membrane fusion GTPase activity" EXACT [] +is_a: GO:0140522 ! fusogenic activity + +[Term] +id: GO:0140525 +name: antipodal site +namespace: cellular_component +def: "The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication." [PMID:12455998, PMID:17462016, PMID:8045928] +synonym: "antipodal zone" EXACT [] +is_a: GO:0020023 ! kinetoplast + +[Term] +id: GO:0140526 +name: double membrane vesicle viral factory assembly +namespace: biological_process +def: "A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle." [PMID:32555292] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0140527 +name: reciprocal homologous recombination +namespace: biological_process +def: "A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules." [PMID:17846636] +is_a: GO:0035825 ! homologous recombination + +[Term] +id: GO:0140528 +name: bilobe structure assembly +namespace: biological_process +def: "The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone)." [PMID:18443217, PMID:32675283] +synonym: "bilobe structure biogenesis" EXACT [] +synonym: "bilobe structure formation" EXACT [] +synonym: "kinetoplastid flagellar hook complex assembly" EXACT [] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:0140529 +name: CMG complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes." [PMID:22718908, PMID:28501329] +is_a: GO:0071163 ! DNA replication preinitiation complex assembly +relationship: part_of GO:1902315 ! nuclear cell cycle DNA replication initiation + +[Term] +id: GO:0140530 +name: MCM complex loading +namespace: biological_process +def: "The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly." [PMID:23603117, PMID:28191893, PMID:28191894, PMID:28501329] +synonym: "MCM complex loading at replication origin" EXACT [] +synonym: "MCM double hexamer formation at replication origin" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:1902315 ! nuclear cell cycle DNA replication initiation + +[Term] +id: GO:0140531 +name: regulation of osmosensory signaling MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osmosensory signaling MAPK cascade." [PMID:31911490] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +is_a: GO:0120027 ! regulation of osmosensory signaling pathway +relationship: regulates GO:0000161 ! osmosensory signaling MAPK cascade + +[Term] +id: GO:0140532 +name: negative regulation of osmosensory signaling MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmosensory signaling MAPK cascade." [PMID:31911490] +is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade +is_a: GO:0120028 ! negative regulation of osmosensory signaling pathway +is_a: GO:0140531 ! regulation of osmosensory signaling MAPK cascade +relationship: negatively_regulates GO:0000161 ! osmosensory signaling MAPK cascade + +[Term] +id: GO:0140533 +name: suppression of host RNAi-mediated antiviral immune response +namespace: biological_process +def: "Any process in which a symbiont stops, prevents, or reduces the rate or extent of the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17693253] +synonym: "suppression of host RNAi-mediated antiviral immunity" EXACT [] +synonym: "suppression of host RNAi-mediated gene silencing" EXACT [] +is_a: GO:0052170 ! suppression by symbiont of host innate immune response + +[Term] +id: GO:0140534 +name: endoplasmic reticulum protein-containing complex +namespace: cellular_component +def: "A protein complex that is part of an endoplasmic reticulum." [GOC:pg] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:0140535 +name: intracellular protein-containing complex +namespace: cellular_component +def: "A protein-containing complex located intracellularly." [GOC:pg] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0140536 +name: nuclear receptor corepressor activity +namespace: molecular_function +def: "A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [PMID:7566114, PMID:7566126, PMID:9238851] +comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. +synonym: "nuclear corepressor activity" BROAD [] +is_a: GO:0003714 ! transcription corepressor activity + +[Term] +id: GO:0140537 +name: transcription regulator activator activity +namespace: molecular_function +def: "A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification." [PMID:9597751] +comment: Usage guidance: transcription regulator activators bind to a transcription regulator to allow it to reach the chromatin or to contact other transcriptional regulators. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001216 ; DNA-binding transcription activator activity or GO:0003713; transcription coactivator activity; those activities respectively bind DNA themselves or positively regulate a transcription regulator when it is located at the chromatin. +is_a: GO:0140677 ! molecular function activator activity + +[Term] +id: GO:0140538 +name: negative regulation of conjugation with zygote +namespace: biological_process +def: "A process that prevents a zygote from fusing an additional cell." [PMID:30089908] +is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion + +[Term] +id: GO:0140539 +name: regulation of melanotic encapsulation of foreign target +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of melanotic encapsulation of foreign target." [PMID:15749104, PMID:18457993] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0035007 ! regulation of melanization defense response +relationship: regulates GO:0035011 ! melanotic encapsulation of foreign target + +[Term] +id: GO:0140540 +name: negative regulation melanotic encapsulation of foreign target +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target." [PMID:15749104, PMID:18457993] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0035009 ! negative regulation of melanization defense response +is_a: GO:0140539 ! regulation of melanotic encapsulation of foreign target +relationship: negatively_regulates GO:0035011 ! melanotic encapsulation of foreign target + +[Term] +id: GO:0140541 +name: piRNA transcription +namespace: biological_process +def: "The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [PMID:28847004] +synonym: "Piwi-associated RNA transcription" EXACT [] +synonym: "PIWI-interacting RNA transcription" EXACT [] +is_a: GO:0034660 ! ncRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0140542 +name: regulation of piRNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of a piRNA." [PMID:28847004] +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0140541 ! piRNA transcription + +[Term] +id: GO:0140543 +name: positive regulation of piRNA transcription +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the synthesis of piRNA." [PMID:28847004] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:0140542 ! regulation of piRNA transcription +relationship: positively_regulates GO:0140541 ! piRNA transcription + +[Term] +id: GO:0140544 +name: septin collar organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising the septin collar." [PMID:21736496, PMID:32386534] +synonym: "cellular bud neck septin hourglass organization" EXACT [] +is_a: GO:0032185 ! septin cytoskeleton organization + +[Term] +id: GO:0140545 +name: protein disaggregase activity +namespace: molecular_function +def: "An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates." [PMID:26312418] +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0140546 +name: defense response to symbiont +namespace: biological_process +def: "Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont." [GOC:pg] +is_a: GO:0098542 ! defense response to other organism + +[Term] +id: GO:0140547 +name: acquisition of seed longevity +namespace: biological_process +def: "The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes." [PMID:26637538] +is_a: GO:0022414 ! reproductive process +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0048316 ! seed development + +[Term] +id: GO:0140548 +name: envenomation resulting in blood agglutination in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism." [PMID:10484740] +synonym: "envenomation resulting in blood agglutination in other organism" EXACT [] +synonym: "envenomation resulting in erythrocytes agglutination in other organism" EXACT [] +synonym: "envenomation resulting in red blood cells agglutination in other organism" EXACT [] +is_a: GO:0035738 ! envenomation resulting in modulation of process in another organism + +[Term] +id: GO:0140549 +name: spore inner membrane +namespace: cellular_component +def: "The membrane surrounding the spore core (endospore core) that separates it from its external environment." [PMID:23202530] +synonym: "spore membrane" BROAD [] +is_a: GO:0016020 ! membrane + +[Term] +id: GO:0140550 +name: phosphatidylinositol-4,5-bisphosphate sensor activity +namespace: molecular_function +def: "Binding to and responding, e.g. by conformational change, to changes in the cellular level of phosphatidylinositol-4,5-bisphosphate." [PMID:33172987] +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0140552 +name: TEAD-YAP complex +namespace: cellular_component +alt_id: GO:0071147 +alt_id: GO:0071148 +alt_id: GO:0071149 +alt_id: GO:0071150 +alt_id: GO:0071151 +def: "A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP." [GOC:mah, PMID:11358867] +synonym: "TEAD-1-YAP complex" NARROW [] +synonym: "TEAD-2 multiprotein complex" NARROW [] +synonym: "TEAD-2-YAP complex" NARROW [] +synonym: "TEAD-3-YAP complex" NARROW [] +synonym: "TEAD-4-YAP complex" NARROW [] +xref: CORUM:2870 +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:0140560 +name: xylosyl alpha-1,3-xylosyltransferase activity +namespace: molecular_function +def: "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains." [PMID:22117070, PMID:8982869, RHEA:22820] +xref: EC:2.4.2.62 +xref: RHEA:22820 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0140561 +name: EGF-domain serine glucosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine." [RHEA:58116] +xref: EC:2.4.1.376 +xref: RHEA:58116 +is_a: GO:0035251 ! UDP-glucosyltransferase activity + +[Term] +id: GO:0140562 +name: EGF-domain serine xylosyltransferase activity +namespace: molecular_function +def: "Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine." [RHEA:62016] +xref: EC:2.4.2.63 +xref: RHEA:62016 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0140563 +name: UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity +namespace: molecular_function +def: "Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine." [EC:2.4.2.42, PMID:30127001, RHEA:56064] +xref: EC:2.4.2.42 +xref: RHEA:56064 +is_a: GO:0035252 ! UDP-xylosyltransferase activity + +[Term] +id: GO:0140566 +name: histone reader +namespace: molecular_function +def: "A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery." [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351] +synonym: "epigenetic reader" BROAD [] +is_a: GO:0140463 ! chromatin-protein adaptor + +[Term] +id: GO:0140567 +name: transmembrane protein dislocase activity +namespace: molecular_function +def: "The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. The reaction is driven by ATP hydrolysis." [PMID:24821790, PMID:28712723, PMID:32973005] +synonym: "transmembrane helix dislocase" RELATED [] +xref: RHEA:66168 +is_a: GO:0140318 ! protein transporter activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0140568 +name: extraction of mislocalized protein from membrane +namespace: biological_process +def: "The removal of a mislocalized protein from a cellular membrane." [PMID:24821790, PMID:28712723, PMID:32973005] +is_a: GO:0090150 ! establishment of protein localization to membrane + +[Term] +id: GO:0140569 +name: extraction of mislocalized protein from ER membrane +namespace: biological_process +def: "The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane." [PMID:32973005] +is_a: GO:0140568 ! extraction of mislocalized protein from membrane + +[Term] +id: GO:0140570 +name: extraction of mislocalized protein from mitochondrial outer membrane +namespace: biological_process +def: "The removal of a mislocalized protein from the mitochondrial outer membrane." [PMID:32973005] +synonym: "extraction of mislocalized protein from outer mitochondrion membrane" EXACT [] +is_a: GO:0140568 ! extraction of mislocalized protein from membrane + +[Term] +id: GO:0140571 +name: transmembrane ascorbate ferrireductase activity +namespace: molecular_function +def: "Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction." [PMID:16911521, PMID:24449903, RHEA:30403] +synonym: "ascorbate-cytochrome b5 reductase activity" EXACT [] +synonym: "L-ascorbate-cytochrome-b5 reductase activity" EXACT [] +synonym: "L-ascorbate:ferricytochrome-b5 oxidoreductase activity" EXACT [] +xref: EC:7.2.1.3 +xref: MetaCyc:1.10.2.1-RXN +xref: RHEA:30403 +is_a: GO:0015453 ! oxidoreduction-driven active transmembrane transporter activity +is_a: GO:0016722 ! oxidoreductase activity, acting on metal ions + +[Term] +id: GO:0140572 +name: vacuole fission +namespace: biological_process +def: "The division of a vacuole within a cell to form two or more separate vacuoles." [PMID:19643199] +is_a: GO:0048285 ! organelle fission + +[Term] +id: GO:0140573 +name: histone H3-containing nucleosome +namespace: cellular_component +def: "A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures." [PMID:33155135] +synonym: "histone H3 containing nucleosome" EXACT [] +is_a: GO:0000786 ! nucleosome + +[Term] +id: GO:0140575 +name: transmembrane monodehydroascorbate reductase activity +namespace: molecular_function +def: "Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction." [PMID:1623014, RHEA:66524] +xref: RHEA:66524 +is_a: GO:0016491 ! oxidoreductase activity + +[Term] +id: GO:0140576 +name: ascorbate homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of ascorbate at the level of a cell." [PMID:1623014, PMID:17068337, PMID:32547589] +synonym: "cellular ascorbate homeostasis" NARROW [] +is_a: GO:0055081 ! anion homeostasis + +[Term] +id: GO:0140579 +name: obsolete oxidoreductase activity, reducing metal ions +namespace: molecular_function +def: "OBSOLETE. Catalysis of an oxidation-reduction in which the metal ion is reduced." [PMID:14499595] +comment: This term was obsoleted because it is an unnecessary grouping class. +is_obsolete: true +consider: GO:0016722 + +[Term] +id: GO:0140580 +name: mitochondrion autophagosome adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy." [PMID:33138913] +synonym: "mitophagy receptor" EXACT [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140581 +name: P-type monovalent copper transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) -> ADP + phosphate + Cu+(out)." [RHEA:25792] +comment: Note that this enzyme transports Cu(+) or Ag(+), and cannot transport the divalent ions, contrary to EC:7.2.2.9, which mainly transports the divalent copper ion (source: EC:7.2.2.8). +xref: EC:7.2.2.8 +xref: RHEA:25792 +is_a: GO:0005375 ! copper ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0140582 +name: adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by cAMP binding to its receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex." [PMID:9578623] +synonym: "extracellular cAMP signaling pathway" EXACT [] +is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:0140584 +name: chromatin extrusion motor activity +namespace: molecular_function +def: "A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis." [PMID:23074191, PMID:26499245, PMID:27210764] +synonym: "chromatin extrusion activity" EXACT [] +is_a: GO:0015616 ! DNA translocase activity + +[Term] +id: GO:0140585 +name: promoter-enhancer loop anchoring activity +namespace: molecular_function +def: "Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop." [PMID:32213323] +comment: Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element. +synonym: "enhancer-promoter loop anchoring activity" EXACT [] +is_a: GO:0140587 ! chromatin loop anchoring activity + +[Term] +id: GO:0140586 +name: promoter-terminator loop anchoring activity +namespace: molecular_function +def: "Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop." [PMID:19933151] +comment: Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element. +synonym: "terminator-promoter loop anchoring activity" EXACT [] +is_a: GO:0140587 ! chromatin loop anchoring activity + +[Term] +id: GO:0140587 +name: chromatin loop anchoring activity +namespace: molecular_function +def: "Bridging together two DNA loop anchors together, maintaining a chromatin loop." [PMID:32213323] +synonym: "chromosomal loop binding" EXACT [] +synonym: "DNA loop binding" EXACT [] +is_a: GO:0106260 ! DNA-DNA tethering activity + +[Term] +id: GO:0140588 +name: chromatin looping +namespace: biological_process +def: "A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome." [PMID:32213323] +comment: To describe the molecular function associated with chromatin looping, consider 'chromatin extrusion motor activity'; GO:0140584. +synonym: "chromatin folding" RELATED [] +synonym: "chromatin loop assembly" EXACT [] +synonym: "DNA loop extrusion" EXACT [] +synonym: "DNA looping" BROAD [] +is_a: GO:0006325 ! chromatin organization + +[Term] +id: GO:0140590 +name: effector-mediated suppression of host defenses +namespace: biological_process +def: "A process mediated by a molecule secreted by a symbiont that results in the supression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:28082413] +synonym: "effector-mediated suppression of host defenses by symbiont" EXACT [] +is_a: GO:0044414 ! suppression of host defenses by symbiont +is_a: GO:0140415 ! effector-mediated modulation of host defenses by symbiont + +[Term] +id: GO:0140591 +name: nuclear envelope budding +namespace: biological_process +def: "The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm." [PMID:27236823, PMID:32503943] +is_a: GO:0051168 ! nuclear export + +[Term] +id: GO:0140592 +name: histone methyltransferase activity (H3-R8 specific) +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to arginine at position 8 of histone H3." [PMID:20708585, PMID:31533925] +is_a: GO:0008469 ! histone-arginine N-methyltransferase activity + +[Term] +id: GO:0140593 +name: host apoplast +namespace: cellular_component +def: "The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:28082413] +synonym: "host cell apoplast" EXACT [] +is_a: GO:0033643 ! host cell part + +[Term] +id: GO:0140594 +name: xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity +namespace: molecular_function +def: "Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase." [PMID:28082413] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0140595 +name: MIM complex +namespace: cellular_component +def: "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2." [PMID:19944477, PMID:22467864, PMID:33035511] +synonym: "mitochondrial outer import machinery" EXACT [] +is_a: GO:0005742 ! mitochondrial outer membrane translocase complex + +[Term] +id: GO:0140596 +name: TOM complex +namespace: cellular_component +def: "A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane." [PMID:33035511] +synonym: "translocase of the outer mitochondrial membrane" EXACT [] +is_a: GO:0005742 ! mitochondrial outer membrane translocase complex + +[Term] +id: GO:0140597 +name: protein carrier chaperone +namespace: molecular_function +def: "Binding to and carrying a protein between two different cellular components by moving along with the target protein." [PMID:7628437] +synonym: "protein carrier activity" EXACT [] +synonym: "protein chaperone" BROAD [] +is_a: GO:0140104 ! molecular carrier activity + +[Term] +id: GO:0140598 +name: lipoprotein carrier activity +namespace: molecular_function +def: "Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein." [PMID:7628437] +is_a: GO:0140597 ! protein carrier chaperone + +[Term] +id: GO:0140599 +name: mitotic nuclear bridge midzone membrane domain +namespace: cellular_component +def: "A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets." [PMID:25963819, PMID:32502403] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0140512 ! mitotic nuclear bridge midzone + +[Term] +id: GO:0140602 +name: nucleolar ring +namespace: cellular_component +def: "Ring-like structures located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress." [PMID:33176152] +synonym: "NuRs" RELATED [] +is_a: GO:0042405 ! nuclear inclusion body + +[Term] +id: GO:0140603 +name: obsolete ATP hydrolysis activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [GOC:curators] +comment: This term was deprecated because it was created in the wrong branch on the ontology. +is_obsolete: true +replaced_by: GO:0016887 + +[Term] +id: GO:0140604 +name: mycofactocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA." [PMID:21223593, PMID:27312813, PMID:30183269, PMID:30778644, PMID:31381312, PMID:33014324] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:0140605 +name: proton motive force-driven motor activity +namespace: molecular_function +def: "A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella." [PMID:18216858] +is_a: GO:0003774 ! cytoskeletal motor activity + +[Term] +id: GO:0140608 +name: cysteine-type endopeptidase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a cysteine-type endopeptidase." [PMID:32558991] +synonym: "caspase activator activator activity" NARROW [] +is_a: GO:0061133 ! endopeptidase activator activity + +[Term] +id: GO:0140609 +name: phycocyanobilin biosynthetic process +namespace: biological_process +def: "The chemical reactions or pathway resulting in the formation of phycocyanobilin, which involves the oxidative cleavage of heme by a heme oxygenase (HO) to form biliverdin IX alpha. Biliverdin IX alpha is subsequently converted to phycocyanobilin by a ferredoxin-dependent oxidoreductase (PCYA)." [PMID:23345435] +synonym: "phycocyanobilin biosynthesis" EXACT [] +is_a: GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:0140610 +name: RNA sequestering activity +namespace: molecular_function +def: "The selective interaction of a protein with a specific RNA molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell." [PMID:29084823] +is_a: GO:0140313 ! molecular sequestering activity + +[Term] +id: GO:0140612 +name: DNA damage sensor activity +namespace: molecular_function +def: "A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signalling response." [PMID:31995034] +is_a: GO:0140299 ! small molecule sensor activity + +[Term] +id: GO:0140613 +name: P-type manganese transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate." [PMID:11134055, PMID:15590060, PMID:15831496, PMID:21187401, RHEA:66820] +xref: RHEA:66820 +is_a: GO:0005384 ! manganese ion transmembrane transporter activity +is_a: GO:0015662 ! P-type ion transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity + +[Term] +id: GO:0140614 +name: 1,8-dihydroxynaphthalene-melanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin." [PMID:12788746, PMID:23998343] +synonym: "DHN-melanin biosynthesis" EXACT [] +is_a: GO:0019290 ! siderophore biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0042438 ! melanin biosynthetic process + +[Term] +id: GO:0140615 +name: ATP-dependent citrate lyase complex +namespace: cellular_component +def: "A protein complex that catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA." [PMID:12376641] +synonym: "citrate lyase complex" BROAD [] +synonym: "citrate synthase complex" BROAD [] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:0140616 +name: iodotyrosine deiodinase activity +namespace: molecular_function +def: "Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH." [PMID:15289438, PMID:18434651, PMID:25395621, PMID:27643701, RHEA:32479] +synonym: "iodide peroxidase-tyrosine iodinase activity" RELATED [] +synonym: "iodotyrosine deiodase activity" RELATED [] +synonym: "monoiodotyrosine deiodinase activity" RELATED [] +synonym: "tyrosine iodinase activity" RELATED [] +xref: EC:1.21.1.1 +xref: RHEA:32479 +is_a: GO:0046992 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond + +[Term] +id: GO:0140617 +name: transvection +namespace: biological_process +def: "An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression." [PMID:24236213, PMID:33479152] +is_a: GO:0040029 ! regulation of gene expression, epigenetic + +[Term] +id: GO:0140618 +name: ferric-chelate reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH." [RHEA:15061] +synonym: "ferric chelate reductase activity" BROAD [] +synonym: "iron chelate reductase activity" BROAD [] +synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] +synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] +xref: EC:1.16.1.7 +xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN +xref: RHEA:15061 +is_a: GO:0000293 ! ferric-chelate reductase activity +is_a: GO:0016723 ! oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor + +[Term] +id: GO:0140619 +name: DNA strand exchange activator activity +namespace: molecular_function +def: "Binds to and increases a DNA strand exchange activity." [PMID:33493431] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0140620 +name: DNA strand exchange inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces a DNA strand exchange activity." [PMID:33493431] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0140621 +name: type I pilus +namespace: cellular_component +def: "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits." [PMID:28496159, PMID:29345620] +synonym: "type 1 pilus" EXACT [] +synonym: "type I fimbriae" EXACT [] +synonym: "type I pili" EXACT [] +is_a: GO:0009289 ! pilus + +[Term] +id: GO:0140622 +name: ER-to-endosome phospholipid transfer complex +namespace: cellular_component +def: "Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site." [GOC:lnp, PMID:20016005, PMID:24366873] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:0140623 +name: type I pilus assembly +namespace: biological_process +def: "The assembly from its constituent parts of a type I pilus." [PMID:1679330] +synonym: "T1P assembly" BROAD [] +synonym: "type 1 pilus biogenesis" EXACT [] +synonym: "type I fimbria assembly" EXACT [] +synonym: "type I fimbria biogenesis" EXACT [] +synonym: "type I fimbriae assembly" EXACT [] +synonym: "type I fimbriae biogenesis" EXACT [] +synonym: "type I fimbrial assembly" EXACT [] +synonym: "type I fimbrial biogenesis" EXACT [] +synonym: "type I fimbrium assembly" EXACT [] +synonym: "type I fimbrium biogenesis" EXACT [] +is_a: GO:0009297 ! pilus assembly + +[Term] +id: GO:0140624 +name: EGAD pathway +namespace: biological_process +def: "The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation." [PMID:31368600] +is_a: GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:0140625 +name: opioid growth factor receptor activity +namespace: molecular_function +def: "Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes." [PMID:11890982] +synonym: "met-enkephalin receptor activity" RELATED [] +synonym: "metenkefalin receptor activity" RELATED [] +synonym: "methionine enkephalin receptor activity" EXACT [] +is_a: GO:0001653 ! peptide receptor activity + +[Term] +id: GO:0140626 +name: opioid growth factor receptor signaling pathway +namespace: biological_process +def: "The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A)." [PMID:19675283, PMID:19923357] +comment: Note that this term represents the activation of the zeta-opioid receptor. Do not confuse with GO:0038003 ; G protein-coupled opioid receptor signaling pathway, activated by the delta, kappa, mu, and nociceptin opioid receptors. +xref: Wikipedia:OGFr +xref: Wikipedia:Opioid_receptor +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:0140627 +name: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms." [PMID:29775578, PMID:29779948] +synonym: "DesCEND" EXACT [] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0140628 +name: outward rectifier potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel." [PMID:28108814] +is_a: GO:0019870 ! potassium channel inhibitor activity + +[Term] +id: GO:0140629 +name: small conductance calcium-activated potassium channel inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel." [PMID:20562108] +is_a: GO:0019870 ! potassium channel inhibitor activity + +[Term] +id: GO:0140630 +name: all-trans-phytoene synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate." [PMID:12641468, PMID:7896759] +synonym: "phytoene synthase activity" BROAD [] +is_a: GO:0016462 ! pyrophosphatase activity + +[Term] +id: GO:0140631 +name: aldehyde dehydrogenase (NAD+) inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+)." [PMID:33495566] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0140632 +name: inflammasome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex." [PMID:33420028, PMID:33420033, PMID:33542150] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:0140633 +name: CARD8 inflammasome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex." [PMID:33420028, PMID:33420033, PMID:33542150] +is_a: GO:0140632 ! inflammasome complex assembly + +[Term] +id: GO:0140634 +name: CARD8 inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of CARD8 and CASP1." [PMID:33420028, PMID:33420033, PMID:33542150] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0140635 +name: neutrophil dispersal +namespace: biological_process +def: "The movement of a neutrophil away from the site of wound or infection following its initial migration to the site." [PMID:31727891] +is_a: GO:1990266 ! neutrophil migration + +[Term] +id: GO:0140636 +name: copper import into the mitochondrion +namespace: biological_process +def: "The process in which copper is transported from the cytosol into the mitochondrial matrix." [PMID:32979421] +is_a: GO:0015677 ! copper ion import +is_a: GO:0035434 ! copper ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0140638 +name: small ribosomal subunit processing complex +namespace: cellular_component +def: "A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p." [GOC:lnp, PMID:21849504, PMID:25064857] +synonym: "small ribosomal subunit maturation complex" RELATED [] +is_a: GO:1905348 ! endonuclease complex + +[Term] +id: GO:0140639 +name: positive regulation of pyroptosis +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of pyroptosis." [PMID:24626226] +is_a: GO:0043068 ! positive regulation of programmed cell death +relationship: positively_regulates GO:0070269 ! pyroptosis + +[Term] +id: GO:0140640 +name: catalytic activity, acting on a nucleic acid +namespace: molecular_function +def: "Catalytic activity that acts to modify a nucleic acid." [GOC:pg] +is_a: GO:0003824 ! catalytic activity + +[Term] +id: GO:0140641 +name: mitotic spindle formation (spindle phase two) +namespace: biological_process +def: "The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase." [PMID:32723864] +synonym: "metaphase spindle stability" EXACT [] +synonym: "metaphase spindle stabilization" EXACT [] +is_a: GO:0090307 ! mitotic spindle assembly + +[Term] +id: GO:0140642 +name: meiotic spindle formation (spindle phase two) +namespace: biological_process +def: "The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase." [PMID:32723864] +is_a: GO:0090306 ! meiotic spindle assembly + +[Term] +id: GO:0140643 +name: hydroxymethylglutaryl-CoA reductase (NADH) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) <=> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH." [PMID:29224355, RHEA:14833] +comment: Note that this activity is not present in eukaryotes, see PMID:29224355. +synonym: "3-hydroxy-3-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] +synonym: "beta-hydroxy-beta-methylglutaryl CoA-reductase activity" BROAD [EC:1.1.1.88] +synonym: "beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] +synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.88] +synonym: "hydroxymethylglutaryl coenzyme A reductase activity" BROAD [EC:1.1.1.88] +xref: EC:1.1.1.88 +xref: KEGG_REACTION:R02081 +xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN +xref: RHEA:14833 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:0140644 +name: neutrophil extracellular trap +namespace: cellular_component +def: "Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms." [PMID:31172493] +synonym: "NET" BROAD [] +is_a: GO:0043264 ! extracellular non-membrane-bounded organelle + +[Term] +id: GO:0140645 +name: neutrophic extracellular trap formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a neutrophil extracellular trap, a network of extracellular fibers primarily composed of DNA from neutrophils, which bind and neutralizes pathogens." [PMID:28267716] +synonym: "NET formation" BROAD [] +xref: http://purl.obolibrary.org/obo/TXPO_0002149 +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:0140646 +name: negative regulation of pre-B cell receptor expression +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells." [PMID:22949502] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0002330 ! pre-B cell receptor expression + +[Term] +id: GO:0140647 +name: P450-containing electron transport chain +namespace: biological_process +def: "A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways." [PMID:16042601] +synonym: "P450-containing system" RELATED [] +xref: Wikipedia:P450-containing_systems +is_a: GO:0022900 ! electron transport chain + +[Term] +id: GO:0140648 +name: positive regulation of cell cycle switching, mitotic to meiotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division." [PMID:22375066] +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0110044 ! regulation of cell cycle switching, mitotic to meiotic cell cycle +relationship: positively_regulates GO:0051728 ! cell cycle switching, mitotic to meiotic cell cycle + +[Term] +id: GO:0140649 +name: cell-to-cell migration by invasive hypha +namespace: biological_process +def: "The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction." [PMID:29567712] +comment: Do not confuse with ' GO:0036267 invasive filamentous growth ', which doesn't include invasion of cells within the host. +synonym: "host tissue colonization" BROAD [] +synonym: "invasive growth" BROAD [] +synonym: "invasive hyphae formation" EXACT [] +synonym: "plant tissue colonization" BROAD [] +is_a: GO:0106259 ! cell-to-cell migration in host + +[Term] +id: GO:0140650 +name: radial glia-guided pyramidal neuron migration +namespace: biological_process +def: "The radial migration of a pyramidal neuron along radial glial cells." [PMID:3760547] +synonym: "radial glia-dependent neuronal migration" EXACT [] +is_a: GO:0001764 ! neuron migration + +[Term] +id: GO:0140651 +name: futile creatine cycle +namespace: biological_process +def: "The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis." [PMID:33597756, PMID:33981039] +is_a: GO:0008152 ! metabolic process +relationship: part_of GO:1990845 ! adaptive thermogenesis + +[Term] +id: GO:0140652 +name: pyripyropene A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyripyropene A." [GOC:ach, PMID:21224862, PMID:26019565] +synonym: "pyripyropene A anabolism" EXACT [] +synonym: "pyripyropene A biosynthesis" EXACT [] +synonym: "pyripyropene A formation" EXACT [] +synonym: "pyripyropene A synthesis" EXACT [] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:0140653 +name: fumitremorgin C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumitremorgin C." [GOC:ach, PMID:19226505] +synonym: "fumitremorgin C anabolism" EXACT [] +synonym: "fumitremorgin C biosynthesis" EXACT [] +synonym: "fumitremorgin C formation" EXACT [] +synonym: "fumitremorgin C synthesis" EXACT [] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0140654 +name: tryprostatin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tryprostatin A." [GOC:ach, PMID:19226505] +synonym: "tryprostatin A anabolism" EXACT [] +synonym: "tryprostatin A biosynthesis" EXACT [] +synonym: "tryprostatin A formation" EXACT [] +synonym: "tryprostatin A synthesis" EXACT [] +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:0140655 +name: mitochondrial proliferation +namespace: biological_process +def: "The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell." [PMID:28301064] +is_a: GO:0007005 ! mitochondrion organization + +[Term] +id: GO:0140656 +name: endodeoxyribonuclease activator activity +namespace: molecular_function +def: "Binds to and increases the activity of an endodeoxyribonuclease." [PMID:33836577] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:0140657 +name: ATP-dependent activity +namespace: molecular_function +def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] +comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. +subset: gocheck_do_not_annotate +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_generic +subset: goslim_yeast +synonym: "ATP hydrolysis-dependent activity" EXACT [] +synonym: "ATPase activity" EXACT [] +synonym: "ATPase activity, coupled" EXACT [] +synonym: "ATPase-dependent activity" EXACT [] +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140658 +name: ATP-dependent chromatin remodeler activity +namespace: molecular_function +alt_id: GO:0070615 +def: "An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling." [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222] +synonym: "ATP hydrolysis-dependent chromatin remodeler activity" EXACT [] +synonym: "ATPase-dependent chromatin remodeler activity" EXACT [] +synonym: "nucleosome-activated ATPase activity" RELATED [GOC:mah] +synonym: "nucleosome-dependent ATPase activity" RELATED [] +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA + +[Term] +id: GO:0140659 +name: cytoskeletal motor regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of a motor protein." [PMID:23142046, PMID:33221250] +synonym: "motor activity regulator activity" BROAD [] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0140660 +name: cytoskeletal motor activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a motor protein." [PMID:33221250] +synonym: "motor activity activator activity" BROAD [] +is_a: GO:0140659 ! cytoskeletal motor regulator activity +is_a: GO:0140677 ! molecular function activator activity + +[Term] +id: GO:0140661 +name: cytoskeletal motor inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents, or reduces the activity of a motor protein." [PMID:23142046] +synonym: "motor activity inhibitor activity" BROAD [] +is_a: GO:0140659 ! cytoskeletal motor regulator activity +is_a: GO:0140678 ! molecular function inhibitor activity + +[Term] +id: GO:0140662 +name: ATP-dependent protein folding chaperone +namespace: molecular_function +def: "Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis." [PMID:27365453] +is_a: GO:0044183 ! protein folding chaperone +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0140663 +name: ATP-dependent FeS chaperone activity +namespace: molecular_function +def: "Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis." [PMID:16843540] +is_a: GO:0016530 ! metallochaperone activity +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:0140664 +name: ATP-dependent DNA damage sensor activity +namespace: molecular_function +def: "A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis." [PMID:33302090, PMID:33510387] +is_a: GO:0008094 ! ATP-dependent activity, acting on DNA +is_a: GO:0140612 ! DNA damage sensor activity + +[Term] +id: GO:0140665 +name: ATP-dependent H3-H4 histone complex loader activity +namespace: molecular_function +def: "Loading of a histone H3-H4 complex onto DNA, driven by ATP hydrolysis." [PMID:31848341, PMID:33658433] +synonym: "H3-H4 dimer loading activity" EXACT [] +synonym: "H3-H4 histone chaperone" BROAD [] +synonym: "H3-H4 histone complex loader activity" BROAD [] +synonym: "histone chaperone" RELATED [] +synonym: "histone H3-H4 dimer loading activity" EXACT [] +is_a: GO:0140674 ! ATP-dependent histone loader activity + +[Term] +id: GO:0140666 +name: annealing activity +namespace: molecular_function +alt_id: GO:0097617 +def: "An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule." [PMID:22888405] +synonym: "renaturation" RELATED [] +is_a: GO:0003676 ! nucleic acid binding + +[Term] +id: GO:0140667 +name: regulation of oxytocin production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of oxytocin." [PMID:25096581] +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0036162 ! oxytocin production + +[Term] +id: GO:0140668 +name: positive regulation of oxytocin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of production of oxytocin." [PMID:25096581] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0140667 ! regulation of oxytocin production +relationship: positively_regulates GO:0036162 ! oxytocin production + +[Term] +id: GO:0140669 +name: negative regulation of oxytocin production +namespace: biological_process +def: "Any process that stops, prevents, or reduces the rate of production of oxytocin." [PMID:25096581] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0140667 ! regulation of oxytocin production +relationship: negatively_regulates GO:0036162 ! oxytocin production + +[Term] +id: GO:0140670 +name: ATP-dependent cohesin unloading activity +namespace: molecular_function +def: "Facilitating a conformational change to unload a cohesin complex from sister chromatids, driven by ATP hydrolysis." [PMID:26687354] +is_a: GO:0140083 ! ATP-dependent protein-DNA unloading activity + +[Term] +id: GO:0140671 +name: ADA complex +namespace: cellular_component +def: "A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex." [GOC:bhm, PMID:21734642, PMID:28966424] +synonym: "ADA HAT complex" EXACT [] +synonym: "ADA histone acetyltransferase complex" EXACT [] +synonym: "Ada2/Gcn5/Ada3 transcription activator complex" RELATED [] +synonym: "scADA" NARROW [] +is_a: GO:0070461 ! SAGA-type complex + +[Term] +id: GO:0140672 +name: ATAC complex +namespace: cellular_component +def: "A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation." [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424] +synonym: "Ada two A containing complex" EXACT [] +synonym: "Ada Two-A containing complex" EXACT [] +synonym: "Ada-Two-A-containing complex" EXACT [] +synonym: "ADA2A-containing complex" EXACT [] +synonym: "G-ATAC complex" EXACT [] +synonym: "KAT2A-containing ATAC complex" EXACT [] +synonym: "KAT2B-containing ATAC complex" EXACT [] +is_a: GO:0070461 ! SAGA-type complex + +[Term] +id: GO:0140673 +name: co-transcriptional chromatin reassembly +namespace: biological_process +def: "The reestablishment of chromatin structure that was disrupted upon passage of RNA polymerase II during transcription elongation. This process prevents cryptic intragenic transcription initiation." [PMID:22922743] +comment: Note: Do not confuse with 'GO:0045815 epigenetic maintenance of chromatin in transcription-competent conformation', which describes the maintenance of chromatin in an open conformation (indeendent of transcription). +synonym: "chromatin maintenance during transcription elongation" RELATED [] +synonym: "euchromatin maintenance during transcription elongation" EXACT [] +synonym: "maintainance of chromatin integrity during transcription elongation by RNAPII" EXACT [] +synonym: "maintenance of transcriptionally active chromatin during transcription elongation" EXACT [] +is_a: GO:0031497 ! chromatin assembly +relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:0140674 +name: ATP-dependent histone loader activity +namespace: molecular_function +def: "Depositing a histone or a histone complex onto DNA." [PMID:26459557] +synonym: "histone loader activity" BROAD [] +synonym: "histone loading activity" EXACT [] +is_a: GO:0140658 ! ATP-dependent chromatin remodeler activity + +[Term] +id: GO:0140675 +name: ATP-dependent histone unloader activity +namespace: molecular_function +def: "Removing a histone or a histone complex from DNA." [PMID:26459557] +synonym: "histone unloader activity" BROAD [] +synonym: "histone unloading activity" EXACT [] +is_a: GO:0140658 ! ATP-dependent chromatin remodeler activity + +[Term] +id: GO:0140676 +name: oscillatory cAMP signaling +namespace: biological_process +def: "Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate." [PMID:18657484] +synonym: "cAMP relay" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0140677 +name: molecular function activator activity +namespace: molecular_function +def: "A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0140678 +name: molecular function inhibitor activity +namespace: molecular_function +def: "A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target." [GOC:curators] +is_a: GO:0098772 ! molecular function regulator + +[Term] +id: GO:0140679 +name: ABC-type sodium transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) -> ADP + phosphate + Na(out)." [PMID:9106203] +xref: EC:7.2.2.4 +xref: RHEA:14633 +xref: TC:3.A.1.115.1 +is_a: GO:0015081 ! sodium ion transmembrane transporter activity +is_a: GO:0019829 ! ATPase-coupled cation transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:0140680 +name: histone H3-di/monomethyl-lysine-36 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20531378] +synonym: "histone H3K36me demethylase activity" RELATED [] +synonym: "histone H3K36me2 demethylase activity" BROAD [] +xref: EC:1.14.11.27 +xref: MetaCyc:RXN-8661 +xref: RHEA:42032 +is_a: GO:0051864 ! histone H3-methyl-lysine-36 demethylase activity + +[Term] +id: GO:0140681 +name: histone H3-tri/dimethyl-lysine-36 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:21914792] +synonym: "histone H3K36me2 demethylase activity" BROAD [] +synonym: "histone H3K36me3 demethylase activity" RELATED [] +xref: EC:1.14.11.69 +xref: MetaCyc:RXN-8660 +xref: RHEA:60236 +is_a: GO:0051864 ! histone H3-methyl-lysine-36 demethylase activity + +[Term] +id: GO:0140682 +name: histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470] +synonym: "histone H3K4me demethylase activity" RELATED [] +synonym: "histone H3K4me2 demethylase activity" BROAD [] +xref: EC:1.14.99.66 +xref: RHEA:60244 +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0032453 ! histone H3-methyl-lysine-4 demethylase activity + +[Term] +id: GO:0140683 +name: histone H3-di/monomethyl-lysine-9 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:16603238] +synonym: "histone H3K9me demethylase activity" BROAD [] +synonym: "histone H3K9me2 demethylase activity" BROAD [] +xref: EC:1.14.11.65 +xref: RHEA:60188 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032454 ! histone H3-methyl-lysine-9 demethylase activity + +[Term] +id: GO:0140684 +name: histone H3-tri/dimethyl-lysine-9 demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate." [PMID:20208542, PMID:20531378] +synonym: "histone H3K9me2 demethylase activity" BROAD [] +synonym: "histone H3K9me3 demethylase activity" RELATED [] +xref: EC:1.14.11.66 +xref: RHEA:60200 +is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity +is_a: GO:0032454 ! histone H3-methyl-lysine-9 demethylase activity + +[Term] +id: GO:0140685 +name: histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction." [PMID:22473470] +synonym: "histone H3K9me demethylase activity" BROAD [] +synonym: "histone H3K9me2 demethylase activity" BROAD [] +is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen +is_a: GO:0032454 ! histone H3-methyl-lysine-9 demethylase activity + +[Term] +id: GO:0140690 +name: dihydropyrimidine dehydrogenase (NAD+) complex +namespace: cellular_component +def: "A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT." [PMID:21169495, PMID:34097066] +xref: MetaCyc:CPLX0-7788 +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:0140691 +name: RNA folding chaperone +namespace: molecular_function +def: "Binding to an RNA or an RNA-containing complex to assist the folding process." [PMID:31165735] +subset: goslim_generic +is_a: GO:0003674 ! molecular_function + +[Term] +id: GO:0140692 +name: very long-chain fatty acid omega-hydroxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]." [PMID:16547005] +is_a: GO:0120250 ! fatty acid omega-hydroxylase activity + +[Term] +id: GO:0140693 +name: molecular condensate scaffold activity +namespace: molecular_function +def: "Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate." [PMID:28225081] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:0140694 +name: non-membrane-bounded organelle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle." [PMID:28225081] +synonym: "non-membrane-bounded organelle formation" EXACT [] +synonym: "non-membrane-enclosed organelle assembly" EXACT [] +synonym: "non-membrane-enclosed organelle formation" EXACT [] +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:0140696 +name: (S)-2-hydroxyglutarate dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol." [PMID:30498244, RHEA:58664] +synonym: "L-2-hydroxyglutarate dehydrogenase activity" EXACT [] +xref: EC:1.1.5.13 +xref: RHEA:58664 +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:0140698 +name: attachment of telomeric heterochromatin to nuclear envelope +namespace: biological_process +def: "The process in which physical connections are formed between sub-telomeric heterochromatin and the nuclear envelope facilitating bouquet formation." [PMID:31635174] +synonym: "attachment of telomeres to nuclear envelope" BROAD [] +synonym: "attachment of telomeric chromatin to nuclear envelope" BROAD [] +synonym: "heterochromatin organization" BROAD [] +is_a: GO:0097240 ! chromosome attachment to the nuclear envelope + +[Term] +id: GO:0140699 +name: cyclic GMP-AMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." [PMID:23258413] +comment: Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that descibes the position of the phosphate group on the cGAMP molecule. +subset: gocheck_do_not_annotate +synonym: "cyclic-GMP-AMP synthase activity" EXACT [] +is_a: GO:0016779 ! nucleotidyltransferase activity + +[Term] +id: GO:0140700 +name: 3',2'-cyclic GMP-AMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP)." [PMID:34261127] +synonym: "3',2' cyclic-GMP-AMP synthase activity" EXACT [] +synonym: "3',2'-cyclic GAMP synthase activity" EXACT [] +is_a: GO:0140699 ! cyclic GMP-AMP synthase activity + +[Term] +id: GO:0140701 +name: 3',3'-cyclic GMP-AMP synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP)." [PMID:30787435, RHEA:35647] +synonym: "3',3' cyclic-GAMP synthase activity" EXACT [] +synonym: "3',3' cyclic-GMP-AMP synthase activity" EXACT [] +synonym: "3',3'-cyclic GAMP synthase activity" EXACT [] +xref: RHEA:35647 +is_a: GO:0140699 ! cyclic GMP-AMP synthase activity + +[Term] +id: GO:0140702 +name: cyclic GMP-AMP binding +namespace: molecular_function +def: "Binding to cyclic GMP-AMP (cGAMP) nucleotide." [PMID:23258412] +subset: gocheck_do_not_annotate +is_a: GO:0030551 ! cyclic nucleotide binding +is_a: GO:0032559 ! adenyl ribonucleotide binding +is_a: GO:0032561 ! guanyl ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:0140703 +name: 3',3'-cyclic GMP-AMP binding +namespace: molecular_function +def: "Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages." [PMID:30787435] +synonym: "3',3' cyclic-GMP-AMP binding" EXACT [] +synonym: "3',3'-cGAMP binding" EXACT [] +synonym: "3',3'-cGMP-AMP binding" EXACT [] +synonym: "3',3'-cyclic GAMP binding" EXACT [] +is_a: GO:0030551 ! cyclic nucleotide binding + +[Term] +id: GO:0140704 +name: 3',2'-cyclic GMP-AMP binding +namespace: molecular_function +def: "Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages." [PMID:34261127] +synonym: "3',2' cyclic-GMP-AMP binding" EXACT [] +synonym: "3',2'-cGAMP binding" EXACT [] +synonym: "3',2'-cyclic GAMP binding" EXACT [] +is_a: GO:0030551 ! cyclic nucleotide binding + +[Term] +id: GO:0140706 +name: protein-containing complex localization to centriolar satellite +namespace: biological_process +def: "A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite." [PMID:27979967] +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0140707 +name: chromatin-nuclear membrane anchor activity +namespace: molecular_function +def: "Binding to chromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization, or to enable equal segregation of the nuclear membrane during mitosis." [PMID:24184107] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:0140708 +name: CAT tailing +namespace: biological_process +def: "The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control sytem." [PMID:25554787, PMID:32934225] +is_a: GO:0002182 ! cytoplasmic translational elongation +relationship: part_of GO:1990116 ! ribosome-associated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:0140709 +name: Frizzled Nuclear Import pathway +namespace: biological_process +def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by internalization and cleavage of the frizzled receptor to yeild a C-terminal fragment that is imported into the nucleus. The frizzled C-terminal fragment is incorporated into large ribonucleoprotein particles and stimulates their egress via nuclear budding." [PMID:22510459, PMID:22579286] +synonym: "FNI" BROAD [] +synonym: "Frizzled Nuclear Import Wnt Pathway" EXACT [] +is_a: GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:0140710 +name: regulation of Frizzled Nuclear Import pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286] +synonym: "regulation of FNI" BROAD [] +synonym: "regulation of Frizzled Nuclear Import Wnt Pathway" EXACT [] +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: regulates GO:0140709 ! Frizzled Nuclear Import pathway + +[Term] +id: GO:0140711 +name: positive regulation of Frizzled Nuclear Import pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286] +synonym: "positive regulation of FNI" BROAD [] +synonym: "positive regulation of Frizzled Nuclear Import Wnt Pathway" EXACT [] +is_a: GO:0140710 ! regulation of Frizzled Nuclear Import pathway +is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway +relationship: positively_regulates GO:0140709 ! Frizzled Nuclear Import pathway + +[Term] +id: GO:0140712 +name: negative regulation of Frizzled Nuclear Import pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a Frizzled Nuclear Import pathway." [PMID:22510459, PMID:22579286] +synonym: "negative regulation of FNI" BROAD [] +synonym: "negative regulation of Frizzled Nuclear Import Wnt Pathway" EXACT [] +is_a: GO:0140710 ! regulation of Frizzled Nuclear Import pathway +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +relationship: negatively_regulates GO:0140709 ! Frizzled Nuclear Import pathway + +[Term] +id: GO:0140713 +name: histone chaperone activity +namespace: molecular_function +def: "Binding to and carrying a histone or a histone complex until it is deposited on DNA, or degraded." [PMID:26459557] +synonym: "histone carrier activity" EXACT [] +is_a: GO:0140597 ! protein carrier chaperone + +[Term] +id: GO:0140714 +name: large ribosomal subunit pre-assembly complex +namespace: cellular_component +def: "A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae)." [GOC:lnp, PMID:17145778, PMID:9528757] +is_a: GO:0101031 ! chaperone complex + +[Term] +id: GO:0140715 +name: serine-tRNA ligase complex +namespace: cellular_component +def: "A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser)." [PMID:30943413] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:0140717 +name: entry into host through the stromata +namespace: biological_process +def: "Entry of a symbiont into host plant tissue via the stromata, microscopic pores in the epidermis of the aerial parts of terrestrial plants. These pores are essential for photosynthesis, as they allow CO(2) to diffuse into the plant. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16959560, PMID:17419713, PMID:29307013] +is_a: GO:0044409 ! entry into host + +[Term] +id: GO:0140718 +name: facultative heterochromatin assembly +namespace: biological_process +def: "The assembly of facultative heterochromatin, heterochromatin that can be converted to euchromatin and allow transcription under specific contexts. These can be temporal (e.g., developmental states or specific cell-cycle stages), spatial (e.g., nuclear localization changes from the center to the periphery or vice versa due to exogenous factors/signals), or parental/heritable (e.g., monoallelic gene expression)." [PMID:17936700] +synonym: "fHC assembly" EXACT [] +is_a: GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0140719 +name: constitutive heterochromatin assembly +namespace: biological_process +def: "The assembly of constitutive heterochromatin, heterochromatin that is always in a conformation refactory to transcription." [PMID:17936700] +is_a: GO:0031507 ! heterochromatin assembly + +[Term] +id: GO:0140720 +name: subtelomeric heterochromatin +namespace: cellular_component +def: "Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3)." [PMID:34576871] +is_a: GO:0000792 ! heterochromatin +relationship: part_of GO:0099115 ! chromosome, subtelomeric region + +[Term] +id: GO:0140721 +name: nuclease inhibitor activity +namespace: molecular_function +def: "Binds to and modulates the activity of a nuclease." [PMID:28785032, PMID:29554913, PMID:30046034] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:0140722 +name: mycophenolic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mycophenolic acid (MPA). MPA is the first isolated antibiotic natural product in the world obtained from a culture of Penicillium brevicompactum in 1893." [PMID:21398490, PMID:26751579, PMID:31209052] +synonym: "MPA anabolism" BROAD [] +synonym: "MPA biosynthesis" BROAD [] +synonym: "MPA formation" BROAD [] +synonym: "MPA synthesis" BROAD [] +synonym: "mycophenolic acid anabolism" EXACT [] +synonym: "mycophenolic acid biosynthesis" EXACT [] +synonym: "mycophenolic acid formation" EXACT [] +synonym: "mycophenolic acid synthesis" EXACT [] +is_a: GO:0017000 ! antibiotic biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0140723 +name: patulin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria." [PMID:25120234, PMID:30680886] +synonym: "patulin anabolism" EXACT [] +synonym: "patulin biosynthesis" EXACT [] +synonym: "patulin formation" EXACT [] +synonym: "patulin synthesis" EXACT [] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process + +[Term] +id: GO:0140724 +name: positive regulation of patulin biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of patulin." [PMID:25625822] +synonym: "positive regulation of patulin anabolism" EXACT [] +synonym: "positive regulation of patulin formation" EXACT [] +synonym: "positive regulation of patulin synthesis" EXACT [] +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +relationship: positively_regulates GO:0140723 ! patulin biosynthetic process + +[Term] +id: GO:0140725 +name: detoxification of free heme +namespace: biological_process +def: "Any process that reduces or removes the toxicity of free heme. These include transport of heme away from sensitive areas and to compartments or complexes whose purpose is sequestration of heme." [PMID:26741528, PMID:32983129] +synonym: "free heme detoxification" EXACT [] +is_a: GO:0098754 ! detoxification + +[Term] +id: GO:0140727 +name: siRNA-dependent pericentric heterochromatin assembly +namespace: biological_process +def: "The assembly of pericentric heterochromatin by a process mediated by a small interfering RNA." [PMID:15289661] +synonym: "siRNA dependent pericentric heterochromatin assembly" EXACT [] +is_a: GO:0031508 ! pericentric heterochromatin assembly + +[Term] +id: GO:0140728 +name: GC-box binding +namespace: molecular_function +def: "Binding to a GC-box, a DNA motif with the consensus sequence GGGCGG that is located upstream of the start point of eukaryotic transcription units. The GC-box may occur in multiple copies or in either orientation relative to the transcription start site." [PMID:14701757] +synonym: "GC box binding" EXACT [] +synonym: "GC rich promoter region binding" BROAD [] +synonym: "GC-rich region binding" BROAD [] +synonym: "GC_rich_promoter_region binding" BROAD [] +is_a: GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding + +[Term] +id: GO:0140729 +name: self-resistance to endogenously produced metabolite +namespace: biological_process +def: "A process that reduces or removes the toxicity of an endogenously produced substance. Mechanisms of resistance to endogenously produced compounds include modification the compound, export, sequestration, or mutations in the target enzyme." [PMID:21923907, PMID:29763292] +synonym: "prevention of self-toxicity" EXACT [] +synonym: "self-resistance to bioactive secondary metabolite" EXACT [] +synonym: "self-resistance to endogenously produced compound" EXACT [] +synonym: "self-resistance to endogenously produced toxin" EXACT [] +is_a: GO:0098754 ! detoxification + +[Term] +id: GO:0140730 +name: amphiregulin production +namespace: biological_process +def: "The appearance of amphiregulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor." [PMID:24463227] +comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. +subset: gocheck_do_not_annotate +synonym: "AREG production" BROAD [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0140731 +name: regulation of amphiregulin production +namespace: biological_process +def: "Any process that modulates the frequency, rate, or extent of production of amphiregulin." [PMID:24463227] +synonym: "regulation of AREG production" BROAD [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0140730 ! amphiregulin production + +[Term] +id: GO:0140732 +name: positive regulation of amphiregulin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of production of amphiregulin." [PMID:24463227] +synonym: "positive regulation of AREG production" BROAD [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0140731 ! regulation of amphiregulin production +relationship: positively_regulates GO:0140730 ! amphiregulin production + +[Term] +id: GO:0140733 +name: tRNA ligase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of a tRNA ligase, an enzyme that catalyzes the formation of aminoacyl-tRNA." [PMID:30943413] +is_a: GO:0008047 ! enzyme activator activity +is_a: GO:0055103 ! ligase regulator activity + +[Term] +id: GO:0140734 +name: ammonium excretion +namespace: biological_process +def: "The elimination of ammonium ions from an excretory cell." [PMID:25740900] +synonym: "ammonia excretion" RELATED [] +is_a: GO:0007588 ! excretion + +[Term] +id: GO:0140735 +name: lovastatin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lovastatin (also known as mevinolin, mevacor or monacolin K), a hypolipidemic inhibitor of (3S)-hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)." [PMID:10334994, PMID:10381407] +synonym: "lovastatin anabolism" EXACT [] +synonym: "lovastatin biosynthesis" EXACT [] +synonym: "lovastatin formation" EXACT [] +synonym: "lovastatin synthesis" EXACT [] +synonym: "mevacor anabolism" EXACT [] +synonym: "mevacor biosynthesis" EXACT [] +synonym: "mevacor biosynthetic process" EXACT [] +synonym: "mevacor formation" EXACT [] +synonym: "mevacor synthesis" EXACT [] +synonym: "mevinolin anabolism" EXACT [] +synonym: "mevinolin biosynthesis" EXACT [] +synonym: "mevinolin biosynthetic process" EXACT [] +synonym: "mevinolin formation," EXACT [] +synonym: "mevinolin synthesis" EXACT [] +synonym: "monacolin K anabolism" EXACT [] +synonym: "monacolin K biosynthesis" EXACT [] +synonym: "monacolin K biosynthetic process" EXACT [] +synonym: "monacolin K formation" EXACT [] +synonym: "monacolin K synthesis" EXACT [] +xref: KEGG_PATHWAY:M00893 +xref: MetaCyc:PWY-7535 +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:0140736 +name: positive regulation of lovastatin biosynthetic process +namespace: biological_process +def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of lovastin." [PMID:10334994, PMID:19781329] +synonym: "positive regulation of mevacor biosynthetic process" EXACT [] +synonym: "positive regulation of mevinolin biosynthetic process" EXACT [] +synonym: "positive regulation of monacolin K biosynthetic process" EXACT [] +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +relationship: positively_regulates GO:0140735 ! lovastatin biosynthetic process + +[Term] +id: GO:0140737 +name: encapsulin nanocompartment +namespace: cellular_component +def: "Intracellular non-membrane bound organelle, consisting of proteinaceous polyhedral shells that encapsulate enzymes, protecting the contents from their surrounding milieu and/or the milieu from reactants in their interior. The self-assembling, 25-42 nm nanocompartment shell, unlike larger bacterial microcompartments, is made of only one protein, and has only a few proteins inside. Shells about vary from about 25-42 nm in diameter. The shell protein has an HK97-like fold and probably evolved from a viral protein. Artificial encapsulin nanocompartments can be expressed and filled with cargo proteins for biotechnological uses. They are found in many bacterial and a few archaeal phyla." [PMID:32918485] +synonym: "protein nanocompartment" BROAD [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:0140738 +name: NLRP6 inflammasome complex +namespace: cellular_component +def: "An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11." [PMID:30674671, PMID:34678144] +is_a: GO:0061702 ! inflammasome complex + +[Term] +id: GO:0140739 +name: NLRP6 inflammasome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex." [PMID:30674671, PMID:34678144] +is_a: GO:0140632 ! inflammasome complex assembly + +[Term] +id: GO:0140740 +name: ADP-riboxanase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + H(+) + NH4(+) + nicotinamide." [PMID:34671164] +comment: Note that this activity has two steps: a transfer of an ADP-robose group, followed by the elimitation of an ammonia group. +xref: EC:4.3.99.- +is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups +is_a: GO:0016841 ! ammonia-lyase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:0140741 +name: tRNA U4 sulfurtransferase +namespace: molecular_function +def: "Catalyzes the reaction: ATP + [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + uracil in tRNA + 2 reduced ferredoxin [iron-sulfur] cluster <=> AMP + diphosphate + 4-thiouracil in tRNA + [ThiI sulfur-carrier protein]-L-cysteine + 2 oxidized ferredoxin [iron-sulfur] cluster." [PMID:27791189, PMID:5541999, RHEA:24176] +synonym: "tRNA uracil 4 sulfurtransferase" EXACT [] +synonym: "tRNA uracil 4-sulfurtransferase" EXACT [] +xref: EC:2.8.1.4 +xref: MetaCyc:TRNA-S-TRANSFERASE-RXN +xref: RHEA:24176 +is_a: GO:0016783 ! sulfurtransferase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:0140742 +name: lncRNA transcription +namespace: biological_process +def: "The transcription of lncRNAs, non-coding RNAs over 200 nucleotides in length, from a DNA template." [PMID:33767452, PMID:33913806] +is_a: GO:0034660 ! ncRNA metabolic process +is_a: GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0140743 +name: regulation of lncRNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the synthesis of a lncRNA." [PMID:33767452, PMID:33913806] +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0140742 ! lncRNA transcription + +[Term] +id: GO:0140744 +name: negative regulation of lncRNA transcription +namespace: biological_process +def: "Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA." [PMID:33767452, PMID:33913806] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0140743 ! regulation of lncRNA transcription +relationship: negatively_regulates GO:0140742 ! lncRNA transcription + +[Term] +id: GO:0140745 +name: siRNA transcription +namespace: biological_process +def: "The transcription of a small interfering RNA from an RNA template." [PMID:23001036] +is_a: GO:0001172 ! transcription, RNA-templated + +[Term] +id: GO:0140746 +name: siRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs)." [PMID:25928405] +is_a: GO:0034661 ! ncRNA catabolic process + +[Term] +id: GO:0140747 +name: regulation of ncRNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription of a non-protein coding gene from a DNA-template." [GOC:pg] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0098781 ! ncRNA transcription + +[Term] +id: GO:0140748 +name: positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process." [PMID:19189958] +is_a: GO:0060624 ! regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process +is_a: GO:0060635 ! positive regulation of (1->3)-beta-D-glucan biosynthetic process +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0034413 ! ascospore wall (1->3)-beta-D-glucan biosynthetic process + +[Term] +id: GO:0140749 +name: phlorizin hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin." [PMID:9762914] +is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds + +[Term] +id: GO:0150001 +name: primary dendrite +namespace: cellular_component +def: "A dendrite emerging from the cell body (the soma) of a neuron." [GOC:aruk, GOC:bc] +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0150002 +name: distal dendrite +namespace: cellular_component +def: "The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:20629984] +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:0150003 +name: regulation of spontaneous synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spontaneous synaptic transmission." [GOC:aruk, GOC:bc, PMID:15457210] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0098814 ! spontaneous synaptic transmission + +[Term] +id: GO:0150004 +name: dendritic spine origin +namespace: cellular_component +def: "The part of the dendritic spine neck where the spine arises from the dendritic shaft." [GOC:aruk, GOC:bc, PMID:9030614] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0044326 ! dendritic spine neck + +[Term] +id: GO:0150005 +name: enzyme activator complex +namespace: cellular_component +def: "A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active." [GOC:bhm, PMID:16244137, PMID:28710280] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:0150006 +name: urease activator complex +namespace: cellular_component +def: "A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function." [GOC:bhm, PMID:16244137, PMID:28710280] +is_a: GO:0150005 ! enzyme activator complex + +[Term] +id: GO:0150007 +name: clathrin-dependent synaptic vesicle endocytosis +namespace: biological_process +def: "Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds." [GOC:aruk, GOC:bc, GOC:ha, PMID:16982422, PMID:18579735, PMID:18579748, PMID:26430111, PMID:27252645, PMID:28391090, PMID:4348786] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0048488 ! synaptic vesicle endocytosis +is_a: GO:0072583 ! clathrin-dependent endocytosis +relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome + +[Term] +id: GO:0150008 +name: bulk synaptic vesicle endocytosis +namespace: biological_process +def: "Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse." [GOC:aruk, GOC:bc, GOC:ha, PMID:18250322, PMID:18579735, PMID:19266323, PMID:26430111, PMID:28391090] +synonym: "activity-dependent bulk endocytosis" EXACT [] +synonym: "activity-dependent bulk synaptic vesicle endocytosis" EXACT [] +synonym: "ADBE" EXACT [] +synonym: "bulk endocytosis" EXACT [] +is_a: GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:0150011 +name: regulation of neuron projection arborization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] +synonym: "regulation of neurite arborization" EXACT [] +synonym: "regulation of neurite branching" EXACT [] +synonym: "regulation of neuron projection branching" EXACT [] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0031344 ! regulation of cell projection organization +relationship: regulates GO:0140058 ! neuron projection arborization + +[Term] +id: GO:0150012 +name: positive regulation of neuron projection arborization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] +synonym: "positive regulation of neurite arborization" EXACT [] +synonym: "positive regulation of neurite branching" EXACT [] +synonym: "positive regulation of neuron projection branching" EXACT [] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0150011 ! regulation of neuron projection arborization +relationship: positively_regulates GO:0140058 ! neuron projection arborization + +[Term] +id: GO:0150013 +name: negative regulation of neuron projection arborization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches." [GOC:aruk, GOC:bc, PMID:17114044] +synonym: "negative regulation of neurite arborization" EXACT [] +synonym: "negative regulation of neurite branching" EXACT [] +synonym: "negative regulation of neuron projection branching" EXACT [] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0150011 ! regulation of neuron projection arborization +relationship: negatively_regulates GO:0140058 ! neuron projection arborization + +[Term] +id: GO:0150014 +name: apical distal dendrite +namespace: cellular_component +def: "Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma)." [GO:bc, GOC:aruk, PMID:1720142, PMID:20629984, PMID:9214543] +is_a: GO:0097440 ! apical dendrite +is_a: GO:0150002 ! distal dendrite + +[Term] +id: GO:0150015 +name: apical proximal dendrite +namespace: cellular_component +def: "The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:1720142, PMID:9214543] +is_a: GO:0097440 ! apical dendrite +is_a: GO:1990635 ! proximal dendrite + +[Term] +id: GO:0150016 +name: basal distal dendrite +namespace: cellular_component +def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:17046728, PMID:1720142, PMID:20629984, PMID:22683681, PMID:9214543] +is_a: GO:0097441 ! basal dendrite +is_a: GO:0150002 ! distal dendrite + +[Term] +id: GO:0150017 +name: basal proximal dendrite +namespace: cellular_component +def: "Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma)." [GOC:aruk, GOC:bc, PMID:16899232, PMID:17046728, PMID:1720142, PMID:22683681, PMID:9214543] +is_a: GO:0097441 ! basal dendrite +is_a: GO:1990635 ! proximal dendrite + +[Term] +id: GO:0150018 +name: basal dendrite development +namespace: biological_process +def: "The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0016358 ! dendrite development + +[Term] +id: GO:0150019 +name: basal dendrite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of a basal dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0048813 ! dendrite morphogenesis +relationship: part_of GO:0150018 ! basal dendrite development + +[Term] +id: GO:0150020 +name: basal dendrite arborization +namespace: biological_process +def: "The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0140059 ! dendrite arborization +is_a: GO:0150019 ! basal dendrite morphogenesis + +[Term] +id: GO:0150021 +name: apical dendrite morphogenesis +namespace: biological_process +def: "The process in which the anatomical structures of an apical dendrite are generated and organized." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0048813 ! dendrite morphogenesis +relationship: part_of GO:0150022 ! apical dendrite development + +[Term] +id: GO:0150022 +name: apical dendrite development +namespace: biological_process +def: "The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0016358 ! dendrite development + +[Term] +id: GO:0150023 +name: apical dendrite arborization +namespace: biological_process +def: "The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches." [GOC:aruk, GOC:bc, PMID:22683681] +is_a: GO:0140059 ! dendrite arborization +is_a: GO:0150021 ! apical dendrite morphogenesis + +[Term] +id: GO:0150024 +name: oxidised low-density lipoprotein particle clearance +namespace: biological_process +def: "The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:aruk, GOC:bc, PMID:27607416] +synonym: "ox-LDL particle clearance" EXACT [] +synonym: "oxidised LDL particle clearance" EXACT [] +synonym: "oxidized LDL particle clearance" EXACT [] +synonym: "oxidized low-density lipoprotein particle clearance" EXACT [] +synonym: "oxLDL particle clearance" EXACT [] +is_a: GO:0034381 ! plasma lipoprotein particle clearance + +[Term] +id: GO:0150025 +name: oxidised low-density lipoprotein particle receptor activity +namespace: molecular_function +def: "Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis." [GOC:aruk, GOC:bc, PMID:27607416] +synonym: "ox-LDL particle receptor activity" EXACT [] +synonym: "ox-LDL receptor activity" RELATED [] +synonym: "oxidised LDL particle receptor activity" EXACT [] +synonym: "oxidised LDL receptor activity" RELATED [] +synonym: "oxidised low-density lipoprotein receptor activity" RELATED [] +synonym: "oxidized LDL particle receptor activity" EXACT [] +synonym: "oxidized LDL receptor activity" RELATED [] +synonym: "oxidized low-density lipoprotein particle receptor activity" EXACT [] +synonym: "oxidized low-density lipoprotein receptor activity" RELATED [] +synonym: "oxLDL particle receptor activity" EXACT [] +synonym: "oxLDL receptor activity" RELATED [] +is_a: GO:0030228 ! lipoprotein particle receptor activity + +[Term] +id: GO:0150031 +name: regulation of protein localization to lysosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0061462 ! protein localization to lysosome + +[Term] +id: GO:0150032 +name: positive regulation of protein localization to lysosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0150031 ! regulation of protein localization to lysosome +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0061462 ! protein localization to lysosome + +[Term] +id: GO:0150033 +name: negative regulation of protein localization to lysosome +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome." [GOC:aruk, GOC:bc, PMID:24305806] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0150031 ! regulation of protein localization to lysosome +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0061462 ! protein localization to lysosome + +[Term] +id: GO:0150034 +name: distal axon +namespace: cellular_component +def: "That part of an axon close to and including the growth cone or the axon terminus." [GOC:aruk, GOC:bc, PMID:17202468] +synonym: "distal part of axon" EXACT [] +synonym: "distal part of the axon" EXACT [PMID:17202468] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:0150035 +name: regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:19448629] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0099183 ! trans-synaptic signaling by BDNF, modulating synaptic transmission + +[Term] +id: GO:0150036 +name: regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission." [GOC:aruk, GOC:bc, PMID:27296803] +comment: Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. +subset: goslim_synapse +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0099553 ! trans-synaptic signaling by endocannabinoid, modulating synaptic transmission + +[Term] +id: GO:0150037 +name: regulation of calcium-dependent activation of synaptic vesicle fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion." [GOC:aruk, GOC:bc, PMID:27052163] +subset: goslim_synapse +is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane +relationship: regulates GO:0099502 ! calcium-dependent activation of synaptic vesicle fusion + +[Term] +id: GO:0150038 +name: postsynaptic dense core vesicle exocytosis +namespace: biological_process +def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels." [GOC:aruk, GOC:bc, PMID:19448629] +subset: goslim_synapse +is_a: GO:0051649 ! establishment of localization in cell +is_a: GO:0099003 ! vesicle-mediated transport in synapse +is_a: GO:0099011 ! neuronal dense core vesicle exocytosis + +[Term] +id: GO:0150043 +name: structural constituent of synapse-associated extracellular matrix +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft." [GOC:aruk, GOC:bc, PMID:17189701] +subset: goslim_synapse +synonym: "extra-synaptic extracellular matrix structural constituent" EXACT [] +synonym: "structural constituent of extra-synaptic extracellular matrix" EXACT [] +synonym: "synapse-associated extracellular matrix structural constituent" EXACT [] +is_a: GO:0005201 ! extracellular matrix structural constituent + +[Term] +id: GO:0150044 +name: regulation of postsynaptic dense core vesicle exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis." [GOC:aruk, GOC:bc, PMID:19448629] +subset: goslim_synapse +is_a: GO:1905413 ! regulation of dense core granule exocytosis +relationship: regulates GO:0150038 ! postsynaptic dense core vesicle exocytosis + +[Term] +id: GO:0150045 +name: regulation of synaptic signaling by nitric oxide +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide." [GOC:aruk, GOC:bc, PMID:26311509] +subset: goslim_synapse +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +relationship: regulates GO:0099163 ! synaptic signaling by nitric oxide + +[Term] +id: GO:0150047 +name: G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential +namespace: molecular_function +def: "G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential." [GOC:aruk, GOC:bc, PMID:11498050] +subset: goslim_synapse +synonym: "G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential" EXACT [] +is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity + +[Term] +id: GO:0150048 +name: cerebellar granule cell to Purkinje cell synapse +namespace: cellular_component +def: "A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum." [GOC:aruk, GOC:bc, PMID:12427822] +subset: goslim_synapse +synonym: "cerebellar parallel fiber to Purkinje cell synapse" EXACT [] +is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse + +[Term] +id: GO:0150050 +name: postsynaptic septin cytoskeleton +namespace: cellular_component +def: "The portion of the septin cytoskeleton contained within the postsynapse." [GOC:aruk, GOC:bc, PMID:28065648] +subset: goslim_synapse +is_a: GO:0032156 ! septin cytoskeleton +is_a: GO:0099571 ! postsynaptic cytoskeleton + +[Term] +id: GO:0150051 +name: postsynaptic Golgi apparatus +namespace: cellular_component +def: "The network of the Golgi apparatus structures located within the postsynapse." [GOC:aruk, GOC:bc, PMID:23838184] +subset: goslim_synapse +synonym: "Golgi outpost" RELATED [GOC:aruk, GOC:bc, PMID:21215635] +is_a: GO:0005794 ! Golgi apparatus +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:0150052 +name: regulation of postsynapse assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse." [GOC:aruk, GOC:bc, PMID:16394100, PMID:16672654, PMID:28185854] +subset: goslim_synapse +is_a: GO:0051963 ! regulation of synapse assembly +is_a: GO:0099175 ! regulation of postsynapse organization +relationship: regulates GO:0099068 ! postsynapse assembly + +[Term] +id: GO:0150053 +name: cerebellar climbing fiber to Purkinje cell synapse +namespace: cellular_component +def: "A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata." [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254] +subset: goslim_synapse +synonym: "cerebellar climbing fibre to Purkinje cell synapse" EXACT [] +is_a: GO:0098985 ! asymmetric, glutamatergic, excitatory synapse + +[Term] +id: GO:0150054 +name: regulation of postsynaptic neurotransmitter receptor diffusion trapping +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping." [GOC:aruk, GOC:bc, PMID:20935643] +subset: goslim_synapse +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0065008 ! regulation of biological quality +is_a: GO:1902683 ! regulation of receptor localization to synapse +relationship: regulates GO:0098970 ! postsynaptic neurotransmitter receptor diffusion trapping + +[Term] +id: GO:0150056 +name: amylin receptor complex 1 +namespace: cellular_component +def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY1 complex" EXACT [] +is_a: GO:1903440 ! amylin receptor complex + +[Term] +id: GO:0150057 +name: amylin receptor complex 2 +namespace: cellular_component +def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY2 complex" EXACT [] +is_a: GO:1903440 ! amylin receptor complex + +[Term] +id: GO:0150058 +name: amylin receptor complex 3 +namespace: cellular_component +def: "A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signalling pathways." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY3 complex" EXACT [] +is_a: GO:1903440 ! amylin receptor complex + +[Term] +id: GO:0150059 +name: amylin receptor 1 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY1 signaling pathway" EXACT [] +is_a: GO:0097647 ! amylin receptor signaling pathway + +[Term] +id: GO:0150060 +name: amylin receptor 2 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM)." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY2 signaling pathway" EXACT [] +is_a: GO:0097647 ! amylin receptor signaling pathway + +[Term] +id: GO:0150061 +name: amylin receptor 3 signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos." [GOC:aruk, GOC:bc, PMID:22500019] +synonym: "AMY3 signaling pathway" EXACT [] +is_a: GO:0097647 ! amylin receptor signaling pathway + +[Term] +id: GO:0150062 +name: complement-mediated synapse pruning +namespace: biological_process +def: "Synaptic pruning mediated by complement system signalling." [GOC:aruk, GOC:bc, PMID:18083105, PMID:22632727, PMID:29844190] +synonym: "complement-dependent synapse pruning" EXACT [] +synonym: "synapse clearance" BROAD [] +synonym: "synapse disassembly" BROAD [] +synonym: "synapse elimination" BROAD [] +synonym: "synapse removal" BROAD [] +is_a: GO:0098883 ! synapse pruning + +[Term] +id: GO:0150063 +name: visual system development +namespace: biological_process +def: "The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways." [GOC:aruk, GOC:bc, GOC:krc, PMID:15004427, PMID:20647017, PMID:22632727] +synonym: "optic pathway development" RELATED [] +synonym: "visual pathway development" RELATED [] +is_a: GO:0048880 ! sensory system development + +[Term] +id: GO:0150064 +name: vertebrate eye-specific patterning +namespace: biological_process +def: "Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus." [GOC:aruk, GOC:bc, PMID:16025107, PMID:22632727, PMID:29322522] +synonym: "binocular vision development" RELATED [] +synonym: "eye-specific patterning" BROAD [] +synonym: "eye-specific segregation" BROAD [] +synonym: "vertebrate eye-specific segregation" EXACT [] +is_a: GO:0003002 ! regionalization +relationship: part_of GO:0007417 ! central nervous system development +relationship: part_of GO:0150063 ! visual system development + +[Term] +id: GO:0150065 +name: regulation of deacetylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0150066 +name: negative regulation of deacetylase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0150065 ! regulation of deacetylase activity + +[Term] +id: GO:0150067 +name: regulation of tubulin deacetylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] +is_a: GO:0090043 ! regulation of tubulin deacetylation +is_a: GO:0150065 ! regulation of deacetylase activity + +[Term] +id: GO:0150068 +name: positive regulation of tubulin deacetylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc] +is_a: GO:0090044 ! positive regulation of tubulin deacetylation +is_a: GO:0090045 ! positive regulation of deacetylase activity +is_a: GO:0150067 ! regulation of tubulin deacetylase activity + +[Term] +id: GO:0150069 +name: negative regulation of tubulin deacetylase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity." [GOC:aruk, GOC:bc, PMID:19457097] +is_a: GO:0150066 ! negative regulation of deacetylase activity +is_a: GO:0150067 ! regulation of tubulin deacetylase activity +is_a: GO:1904428 ! negative regulation of tubulin deacetylation + +[Term] +id: GO:0150070 +name: regulation of arginase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:0150071 +name: negative regulation of arginase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:0150070 ! regulation of arginase activity + +[Term] +id: GO:0150072 +name: positive regulation of arginase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of arginase activity." [GOC:aruk, GOC:bc, PMID:26670206] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:0150070 ! regulation of arginase activity + +[Term] +id: GO:0150073 +name: regulation of protein-glutamine gamma-glutamyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:0150074 +name: positive regulation of protein-glutamine gamma-glutamyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc, PMID:26670206] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity + +[Term] +id: GO:0150075 +name: negative regulation of protein-glutamine gamma-glutamyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity." [GOC:aruk, GOC:bc] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:0150073 ! regulation of protein-glutamine gamma-glutamyltransferase activity + +[Term] +id: GO:0150076 +name: neuroinflammatory response +namespace: biological_process +def: "The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] +synonym: "nerve tissue inflammatory response" EXACT [] +synonym: "nervous tissue inflammatory response" EXACT [] +synonym: "neural tissue inflammatory response" EXACT [] +is_a: GO:0006954 ! inflammatory response + +[Term] +id: GO:0150077 +name: regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423] +is_a: GO:0050727 ! regulation of inflammatory response +relationship: regulates GO:0150076 ! neuroinflammatory response + +[Term] +id: GO:0150078 +name: positive regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc] +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0150077 ! regulation of neuroinflammatory response +relationship: positively_regulates GO:0150076 ! neuroinflammatory response + +[Term] +id: GO:0150079 +name: negative regulation of neuroinflammatory response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response." [GOC:aruk, GOC:bc, PMID:11099416, PMID:18164423] +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:0150077 ! regulation of neuroinflammatory response +relationship: negatively_regulates GO:0150076 ! neuroinflammatory response + +[Term] +id: GO:0150086 +name: multiple synapse bouton +namespace: cellular_component +def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344] +synonym: "MSB" EXACT [] +synonym: "multi-synapse" RELATED [] +synonym: "multi-synapse bouton" EXACT [] +synonym: "multi-synaptic bouton" EXACT [] +synonym: "multiple spine synapse bouton" EXACT [] +synonym: "multiple synapse" RELATED [] +synonym: "multiple-synapse bouton" EXACT [] +synonym: "multisynapse" RELATED [] +synonym: "multisynapse bouton" EXACT [] +synonym: "multisynaptic bouton" EXACT [] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:0150087 +name: multiple synapse bouton, contacting single dendrite +namespace: cellular_component +def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234] +synonym: "MSB1" EXACT [PMID:24487234] +synonym: "type 1 multi-synapse bouton" EXACT [PMID:24487234] +synonym: "type 1 multi-synaptic bouton" EXACT [PMID:24487234] +synonym: "type 1 multiple spine synapse bouton" EXACT [PMID:24487234] +synonym: "type 1 multiple-synapse bouton" EXACT [PMID:24487234] +synonym: "type 1 multisynapse bouton" EXACT [PMID:24487234] +synonym: "type 1 multisynaptic bouton" EXACT [PMID:24487234] +is_a: GO:0150086 ! multiple synapse bouton + +[Term] +id: GO:0150088 +name: multiple synapse bouton, contacting multiple dendrites +namespace: cellular_component +def: "A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344] +synonym: "MSB2" EXACT [PMID:24487234] +synonym: "type 2 multi-synapse bouton" EXACT [PMID:24487234] +synonym: "type 2 multi-synaptic bouton" EXACT [PMID:24487234] +synonym: "type 2 multiple spine synapse bouton" EXACT [PMID:24487234] +synonym: "type 2 multiple-synapse bouton" EXACT [PMID:24487234] +synonym: "type 2 multisynapse bouton" EXACT [PMID:24487234] +synonym: "type 2 multisynaptic bouton" EXACT [PMID:24487234] +is_a: GO:0150086 ! multiple synapse bouton + +[Term] +id: GO:0150089 +name: multiple spine synapse organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:11466428, PMID:18501438, PMID:22028887, PMID:29774619, PMID:7482800, PMID:8366344] +synonym: "multi-synapse organisation" BROAD [] +synonym: "multi-synapse organization" BROAD [] +synonym: "multi-synaptic organisation" BROAD [] +synonym: "multi-synaptic organization" BROAD [] +synonym: "multiple spine synapse organisation" EXACT [] +synonym: "multisynapse organisation" BROAD [] +synonym: "multisynapse organization" BROAD [] +synonym: "multisynaptic organisation" BROAD [] +synonym: "multisynaptic organization" BROAD [] +is_a: GO:0050808 ! synapse organization + +[Term] +id: GO:0150090 +name: multiple spine synapse organization, single dendrite +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234] +is_a: GO:0150089 ! multiple spine synapse organization + +[Term] +id: GO:0150091 +name: multiple spine synapse organization, multiple dendrites +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites." [GOC:aruk, GOC:bc, PMID:10586883, PMID:11248111, PMID:22028887, PMID:24487234, PMID:7482800, PMID:8366344] +is_a: GO:0150089 ! multiple spine synapse organization + +[Term] +id: GO:0150092 +name: regulation of synaptic scaling +namespace: biological_process +def: "A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell." [GOC:aruk, GOC:bc, PMID:14630218, PMID:14735113, PMID:16547515] +synonym: "homeostatic synaptic scaling" RELATED [PMID:16547515] +synonym: "regulation of homeostatic synaptic scaling" RELATED [] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:0150093 +name: amyloid-beta clearance by transcytosis +namespace: biological_process +def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:26005850] +is_a: GO:0045056 ! transcytosis +is_a: GO:0097242 ! amyloid-beta clearance + +[Term] +id: GO:0150094 +name: amyloid-beta clearance by cellular catabolic process +namespace: biological_process +def: "The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation." [GOC:aruk, GOC:bc, PMID:18289866] +synonym: "amyloid-beta clearance by phagocytosis" NARROW [] +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0097242 ! amyloid-beta clearance + +[Term] +id: GO:0150098 +name: glial cell-neuron signaling +namespace: biological_process +def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] +synonym: "glia-neuron signaling" EXACT [] +synonym: "glia-neuron signalling" EXACT [] +synonym: "glia-neurone signaling" EXACT [] +synonym: "glia-neurone signalling" EXACT [] +synonym: "glial cell- neuron signalling" EXACT [] +synonym: "glial cell-neurone signalling" EXACT [] +synonym: "glial cell-neurone singaling" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0150099 +name: neuron-glial cell signaling +namespace: biological_process +def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] +synonym: "neuron-glia signaling" EXACT [] +synonym: "neuron-glia signalling" EXACT [] +synonym: "neuron-glial cell signalling" EXACT [] +synonym: "neurone-glia signaling" EXACT [] +synonym: "neurone-glia signalling" EXACT [] +synonym: "neurone-glial cell signaling" EXACT [] +synonym: "neurone-glial cell signalling" EXACT [] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:0150100 +name: RNA binding involved in posttranscriptional gene silencing +namespace: molecular_function +def: "Any RNA binding that is involved in posttranscriptional gene silencing." [GOC:aruk, GOC:bc, GOC:rl, PMID:23985560, PMID:28379604] +synonym: "RNA binding involved in cosuppression" RELATED [] +synonym: "RNA binding involved in post-transcriptional gene silencing" EXACT [] +synonym: "RNA binding involved in PTGS" EXACT [] +synonym: "RNA binding involved in quelling" EXACT [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:0150101 +name: regulation of microtubule anchoring at centrosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome." [GOC:aruk, GOC:bc, PMID:17139249] +is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization +relationship: regulates GO:0034454 ! microtubule anchoring at centrosome + +[Term] +id: GO:0150102 +name: negative regulation of monocyte activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation." [GOC:aruk, PMID:15597323] +synonym: "repression of monocyte activation" EXACT [] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0042117 ! monocyte activation + +[Term] +id: GO:0150103 +name: reactive gliosis +namespace: biological_process +def: "A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells." [GOC:aruk, GOC:bc, PMID:24462092] +synonym: "gliosis" BROAD [] +is_a: GO:0150076 ! neuroinflammatory response + +[Term] +id: GO:0150104 +name: transport across blood-brain barrier +namespace: biological_process +def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008] +synonym: "transport across BBB" EXACT [] +synonym: "transport across blood brain barrier" EXACT [] +is_a: GO:0010232 ! vascular transport + +[Term] +id: GO:0150105 +name: protein localization to cell-cell junction +namespace: biological_process +def: "A process in which a protein is transported to, or maintained, in a location within a cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] +is_a: GO:1902414 ! protein localization to cell junction + +[Term] +id: GO:0150106 +name: regulation of protein localization to cell-cell junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] +is_a: GO:0032880 ! regulation of protein localization +relationship: regulates GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0150107 +name: positive regulation of protein localization to cell-cell junction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc, PMID:26706435] +is_a: GO:0150106 ! regulation of protein localization to cell-cell junction +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0150110 +name: negative regulation of cholesterol esterification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification." [GOC:aruk, GOC:bc, PMID:21810484, PMID:24201375] +is_a: GO:0010872 ! regulation of cholesterol esterification +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +relationship: negatively_regulates GO:0034435 ! cholesterol esterification + +[Term] +id: GO:0150111 +name: regulation of transepithelial transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transepithelial transport." [GOC:aruk, PMID:27593915] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0070633 ! transepithelial transport + +[Term] +id: GO:0150115 +name: cell-substrate junction organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-substrate junction. A cell-substrate junction is a specialized region of connection between a cell and the extracellular matrix." [GOC:aruk, GOC:bc, PMID:10419689, PMID:1643657, PMID:16805308, PMID:26923917, PMID:8314002] +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0150116 +name: regulation of cell-substrate junction organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0150115 ! cell-substrate junction organization + +[Term] +id: GO:0150117 +name: positive regulation of cell-substrate junction organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0150116 ! regulation of cell-substrate junction organization +relationship: positively_regulates GO:0150115 ! cell-substrate junction organization + +[Term] +id: GO:0150118 +name: negative regulation of cell-substrate junction organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell-substrate junction organization." [GOC:aruk] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0150116 ! regulation of cell-substrate junction organization +relationship: negatively_regulates GO:0150115 ! cell-substrate junction organization + +[Term] +id: GO:0150119 +name: negative regulation of protein localization to cell-cell junction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction." [GOC:aruk, GOC:bc] +synonym: "negative regulation of protein localisation to cell-cell junction" EXACT [] +is_a: GO:0150106 ! regulation of protein localization to cell-cell junction +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:0150127 +name: regulation of interleukin-33 production +namespace: biological_process +alt_id: GO:0150123 +alt_id: GO:0150130 +def: "Any process that modulates the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] +synonym: "regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-33 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0072639 ! interleukin-33 production + +[Term] +id: GO:0150128 +name: negative regulation of interleukin-33 production +namespace: biological_process +alt_id: GO:0150124 +alt_id: GO:0150131 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-33 production." [GOC:aruk, PMID:29778524] +synonym: "negative regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-33 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0150127 ! regulation of interleukin-33 production +relationship: negatively_regulates GO:0072639 ! interleukin-33 production + +[Term] +id: GO:0150129 +name: positive regulation of interleukin-33 production +namespace: biological_process +alt_id: GO:0150125 +alt_id: GO:0150132 +def: "Any process that activates or increases the frequency, rate or extent of interleukin-33 production." [GOC:aruk] +synonym: "positive regulation of interleukin-33 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-33 secretion" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0150127 ! regulation of interleukin-33 production +relationship: positively_regulates GO:0072639 ! interleukin-33 production + +[Term] +id: GO:0150136 +name: regulation of interleukin-37 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558] +synonym: "regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0150137 ! interleukin-37 production + +[Term] +id: GO:0150137 +name: interleukin-37 production +namespace: biological_process +def: "The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:30362558] +subset: gocheck_do_not_annotate +synonym: "interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0150138 +name: negative regulation of interleukin-37 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-37 production." [GOC:aruk, PMID:30362558] +synonym: "negative regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0150136 ! regulation of interleukin-37 production +relationship: negatively_regulates GO:0150137 ! interleukin-37 production + +[Term] +id: GO:0150139 +name: positive regulation of interleukin-37 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-37 production." [GOC:aruk] +synonym: "positive regulation of interleukin-37 biosynthetic process" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0150136 ! regulation of interleukin-37 production +relationship: positively_regulates GO:0150137 ! interleukin-37 production + +[Term] +id: GO:0150140 +name: regulation of CD86 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "regulation of CD86 biosynthetic process" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0035781 ! CD86 biosynthetic process + +[Term] +id: GO:0150141 +name: negative regulation of CD86 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "negative regulation of CD86 biosynthetic process" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0150140 ! regulation of CD86 production +relationship: negatively_regulates GO:0035781 ! CD86 biosynthetic process + +[Term] +id: GO:0150142 +name: positive regulation of CD86 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD86 biosynthetic process." [GOC:aruk] +synonym: "positive regulation of CD86 biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0150140 ! regulation of CD86 production +relationship: positively_regulates GO:0035781 ! CD86 biosynthetic process + +[Term] +id: GO:0150143 +name: regulation of CD80 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "regulation of CD80 biosynthetic process" EXACT [] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0035780 ! CD80 biosynthetic process + +[Term] +id: GO:0150144 +name: negative regulation of CD80 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk, PMID:26936882] +synonym: "negative regulation of CD80 biosynthetic process" EXACT [] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +is_a: GO:0150143 ! regulation of CD80 production +relationship: negatively_regulates GO:0035780 ! CD80 biosynthetic process + +[Term] +id: GO:0150145 +name: positive regulation of CD80 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD80 biosynthetic process." [GOC:aruk] +synonym: "positive regulation of CD80 biosynthetic process" EXACT [] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:0150143 ! regulation of CD80 production +relationship: positively_regulates GO:0035780 ! CD80 biosynthetic process + +[Term] +id: GO:0150146 +name: cell junction disassembly +namespace: biological_process +def: "The disaggregation of a cell junction into its constituent components." [GOC:aruk, PMID:25490267] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0034330 ! cell junction organization + +[Term] +id: GO:0150147 +name: cell-cell junction disassembly +namespace: biological_process +def: "The disaggregation of a cell-cell junction into its constituent components." [GOC:aruk, PMID:25490267] +is_a: GO:0045216 ! cell-cell junction organization +is_a: GO:0150146 ! cell junction disassembly + +[Term] +id: GO:0150151 +name: regulation of interleukin-17A production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018] +synonym: "regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032660 ! regulation of interleukin-17 production +relationship: regulates GO:0097087 ! interleukin-17A production + +[Term] +id: GO:0150152 +name: negative regulation of interleukin-17A production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17A production." [GOC:aruk, PMID:27901018] +synonym: "negative regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032700 ! negative regulation of interleukin-17 production +is_a: GO:0150151 ! regulation of interleukin-17A production +relationship: negatively_regulates GO:0097087 ! interleukin-17A production + +[Term] +id: GO:0150153 +name: positive regulation of interleukin-17A production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-17A production." [GOC:aruk] +synonym: "positive regulation of interleukin-17A biosynthetic process" NARROW [] +is_a: GO:0032740 ! positive regulation of interleukin-17 production +is_a: GO:0150151 ! regulation of interleukin-17A production +relationship: positively_regulates GO:0097087 ! interleukin-17A production + +[Term] +id: GO:0150155 +name: interleukin-34 production +namespace: biological_process +def: "The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:aruk, PMID:26754294] +subset: gocheck_do_not_annotate +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:0150157 +name: regulation of interleukin-34 production +namespace: biological_process +alt_id: GO:0150156 +alt_id: GO:0150160 +def: "Any process that modulates the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294] +synonym: "interleukin-34 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-34 biosynthetic process" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0150155 ! interleukin-34 production + +[Term] +id: GO:0150158 +name: positive regulation of interleukin-34 production +namespace: biological_process +alt_id: GO:0150161 +def: "Any process that activates or increases the frequency, rate or extent of interleukin-34 production." [GOC:aruk] +synonym: "positive regulation of interleukin-34 biosynthetic process" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0150157 ! regulation of interleukin-34 production +relationship: positively_regulates GO:0150155 ! interleukin-34 production + +[Term] +id: GO:0150159 +name: negative regulation of interleukin-34 production +namespace: biological_process +alt_id: GO:0150162 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production." [GOC:aruk, PMID:26754294] +synonym: "negative regulation of interleukin-34 biosynthetic process" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0150157 ! regulation of interleukin-34 production +relationship: negatively_regulates GO:0150155 ! interleukin-34 production + +[Term] +id: GO:0150163 +name: miRNA-mediated activation of transcription by RNA polymerase II +namespace: biological_process +def: "Any process mediated by a microRNA (miRNA) that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk, PMID:20737563, PMID:27145859] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:0150164 ! miRNA-mediated regulation of transcription by RNA polymerase II +is_a: GO:1903313 ! positive regulation of mRNA metabolic process +relationship: positively_regulates GO:0042789 ! mRNA transcription by RNA polymerase II + +[Term] +id: GO:0150164 +name: miRNA-mediated regulation of transcription by RNA polymerase II +namespace: biological_process +def: "Any process mediated by a microRNA (miRNA) that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk, PMID:20737563, PMID:27145859] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: regulates GO:0042789 ! mRNA transcription by RNA polymerase II + +[Term] +id: GO:0150165 +name: miRNA-mediated inhibition of transcription by RNA polymerase II +namespace: biological_process +def: "Any process mediated by a microRNA (miRNA) that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:aruk] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0150164 ! miRNA-mediated regulation of transcription by RNA polymerase II +is_a: GO:1903312 ! negative regulation of mRNA metabolic process +relationship: negatively_regulates GO:0042789 ! mRNA transcription by RNA polymerase II + +[Term] +id: GO:0150166 +name: regulation of histone H3-K4 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0043973 ! histone H3-K4 acetylation + +[Term] +id: GO:0150167 +name: positive regulation of histone H3-K4 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk, PMID:20737563] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:0150166 ! regulation of histone H3-K4 acetylation +relationship: positively_regulates GO:0043973 ! histone H3-K4 acetylation + +[Term] +id: GO:0150168 +name: negative regulation of histone H3-K4 acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation." [GOC:aruk] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:0150166 ! regulation of histone H3-K4 acetylation +relationship: negatively_regulates GO:0043973 ! histone H3-K4 acetylation + +[Term] +id: GO:0150172 +name: regulation of phosphatidylcholine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0150173 +name: positive regulation of phosphatidylcholine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0150174 +name: negative regulation of phosphatidylcholine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0046470 ! phosphatidylcholine metabolic process + +[Term] +id: GO:0150175 +name: regulation of phosphatidylethanolamine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0150176 +name: positive regulation of phosphatidylethanolamine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0150175 ! regulation of phosphatidylethanolamine metabolic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0150177 +name: negative regulation of phosphatidylethanolamine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0150175 ! regulation of phosphatidylethanolamine metabolic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0046337 ! phosphatidylethanolamine metabolic process + +[Term] +id: GO:0150178 +name: regulation of phosphatidylserine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0006658 ! phosphatidylserine metabolic process + +[Term] +id: GO:0150179 +name: positive regulation of phosphatidylserine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0006658 ! phosphatidylserine metabolic process + +[Term] +id: GO:0150180 +name: negative regulation of phosphatidylserine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine metabolic process." [GOC:aruk, GOC:bc, PMID:30074985] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0006658 ! phosphatidylserine metabolic process + +[Term] +id: GO:0150189 +name: regulation of interleukin-32 production +namespace: biological_process +alt_id: GO:0150192 +def: "Any process that modulates the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669] +synonym: "regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "regulation of interleukin-32 secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0072637 ! interleukin-32 production + +[Term] +id: GO:0150190 +name: negative regulation of interleukin-32 production +namespace: biological_process +alt_id: GO:0150193 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-32 production." [GOC:aruk, PMID:23729669] +synonym: "negative regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "negative regulation of interleukin-32 secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0150189 ! regulation of interleukin-32 production +relationship: negatively_regulates GO:0072637 ! interleukin-32 production + +[Term] +id: GO:0150191 +name: positive regulation of interleukin-32 production +namespace: biological_process +alt_id: GO:0150194 +def: "Any process that activates or increases the frequency, rate or extent of interleukin-32 production." [GOC:aruk] +synonym: "positive regulation of interleukin-32 biosynthetic process" NARROW [] +synonym: "positive regulation of interleukin-32 secretion" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:0150189 ! regulation of interleukin-32 production +relationship: positively_regulates GO:0072637 ! interleukin-32 production + +[Term] +id: GO:0150195 +name: transport across blood-cerebrospinal fluid barrier +namespace: biological_process +def: "The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier." [GOC:aruk, GOC:bc, PMID:21349151] +synonym: "transport across BCSFB" EXACT [] +synonym: "transport across blood-CSF barrier" EXACT [] +synonym: "transport across blood/cerebrospinal fluid barrier" EXACT [] +synonym: "transport across blood/CSF barrier" EXACT [] +is_a: GO:0010232 ! vascular transport + +[Term] +id: GO:0150200 +name: regulation of transport across blood-brain barrier +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] +is_a: GO:0044057 ! regulation of system process +is_a: GO:0051049 ! regulation of transport +relationship: part_of GO:0043114 ! regulation of vascular permeability +relationship: regulates GO:0150104 ! transport across blood-brain barrier + +[Term] +id: GO:0150201 +name: positive regulation of transport across blood-brain barrier +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0150200 ! regulation of transport across blood-brain barrier +relationship: part_of GO:0043117 ! positive regulation of vascular permeability +relationship: positively_regulates GO:0150104 ! transport across blood-brain barrier + +[Term] +id: GO:0150202 +name: negative regulation of transport across blood-brain barrier +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier." [GOC:aruk, GOC:bc, PMID:29377008, PMID:30280653] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0150200 ! regulation of transport across blood-brain barrier +relationship: negatively_regulates GO:0150104 ! transport across blood-brain barrier +relationship: part_of GO:0043116 ! negative regulation of vascular permeability + +[Term] +id: GO:0160001 +name: extrasynaptic signaling via GABA +namespace: biological_process +def: "Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid." [PMID:23038269, PMID:9364051] +is_a: GO:0007214 ! gamma-aminobutyric acid signaling pathway + +[Term] +id: GO:0160002 +name: ADP-D-ribose modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon ADP-ribosylation of the target protein." [PMID:26673700] +comment: This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. +is_a: GO:0140030 ! modification-dependent protein binding + +[Term] +id: GO:0160003 +name: mono-ADP-D-ribose modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon mono-ADP-ribosylation of the target protein." [PMID:34023495] +comment: This term should only be used when the binding is shown to require a mono-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. +is_a: GO:0160002 ! ADP-D-ribose modification-dependent protein binding + +[Term] +id: GO:0160004 +name: poly-ADP-D-ribose modification-dependent protein binding +namespace: molecular_function +def: "Binding to a protein upon poly-ADP-ribosylation of the target protein." [PMID:26673700] +comment: This term should only be used when the binding is shown to require a poly-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. +is_a: GO:0160002 ! ADP-D-ribose modification-dependent protein binding + +[Term] +id: GO:0160005 +name: PAT complex +namespace: cellular_component +def: "A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane after their release from the Sec61 translocon. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47." [PMID:32814900, PMID:33082068, PMID:33960686] +comment: PAT complex functions by shielding exposed hydrophilicity of transmembrane domains (TMDs) to prevent premature degradation and promote proper folding and bundling of TMDs. +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane + +[Term] +id: GO:0160006 +name: Fc receptor-mediated immune complex endocytosis +namespace: biological_process +def: "An endocytosis process mediated by the Fc receptor for the purpose of delivery of antigen-bound immunoglobulin to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. This process selectively targets antigens for presentation by MHC class II or cross-presentation by MHC class I." [PMID:28389502, PMID:9143687, PMID:9463401] +synonym: "antigen-antibody immune complex uptake via Fc receptor" EXACT [] +synonym: "Fc receptor-mediated immune complex internalization" RELATED [] +synonym: "Ig-complexed antigen endocytosis via Fc receptor" EXACT [] +is_a: GO:0006898 ! receptor-mediated endocytosis +is_a: GO:0031503 ! protein-containing complex localization + +[Term] +id: GO:0160007 +name: glutathione import into mitochondrion +namespace: biological_process +def: "The process in which glutathione is transported from the cytosol into the mitochondrial matrix." [PMID:34707288] +is_a: GO:0034775 ! glutathione transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:0160008 +name: protein decrotonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein]." [PMID:28497810, PMID:30279482, PMID:34608293] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0160009 +name: histone decrotonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]." [PMID:28497810] +is_a: GO:0160008 ! protein decrotonylase activity + +[Term] +id: GO:0160010 +name: protein de-2-hydroxyisobutyrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2-hydroxy-2-methylpropanoate + L-lysyl-[protein]." [PMID:29192674] +is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides + +[Term] +id: GO:0160011 +name: NAD-dependent protein decrotonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[protein] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:28497810] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0160012 +name: NAD-dependent histone decrotonylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl-[histone] + nicotinamide." [PMID:28497810] +is_a: GO:0160011 ! NAD-dependent protein decrotonylase activity + +[Term] +id: GO:0160013 +name: NAD-dependent protein de-2-hydroxyisobutyrylase activity +namespace: molecular_function +def: "Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide." [PMID:31328167] +xref: RHEA:24364 +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:0160014 +name: exopher +namespace: cellular_component +def: "An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles." [PMID:28178240, PMID:33016946, PMID:33027673, PMID:33659873, PMID:34288362, PMID:34475208] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:0160015 +name: platelet rolling +namespace: biological_process +def: "Transient adhesive interactions between platelets and endothelial cells lining blood vessels. Carbohydrates on circulating platelets bind selectins or other molecules on the vessel wall causing the platelets to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between surface molecules of platelets and endothelium." [GOC:sl, PMID:29018081] +is_a: GO:0034113 ! heterotypic cell-cell adhesion + +[Term] +id: GO:0160017 +name: regulation of platelet rolling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of platelet rolling." [GO_REF:0000058, GOC:sl] +is_a: GO:0034114 ! regulation of heterotypic cell-cell adhesion +relationship: regulates GO:0160015 ! platelet rolling + +[Term] +id: GO:0160018 +name: positive regulation of platelet rolling +namespace: biological_process +def: "Any process that increases the rate, frequency, or extent of platelet rolling." [GO_REF:0000058, GOC:sl] +is_a: GO:0034116 ! positive regulation of heterotypic cell-cell adhesion +is_a: GO:0160017 ! regulation of platelet rolling +relationship: positively_regulates GO:0160015 ! platelet rolling + +[Term] +id: GO:0160019 +name: negative regulation of platelet rolling +namespace: biological_process +def: "Any process that decreases the rate, frequency, or extent of platelet rolling." [GO_REF:0000058, GOC:sl, PMID:15738422] +is_a: GO:0034115 ! negative regulation of heterotypic cell-cell adhesion +is_a: GO:0160017 ! regulation of platelet rolling +relationship: negatively_regulates GO:0160015 ! platelet rolling + +[Term] +id: GO:0198738 +name: cell-cell signaling by wnt +namespace: biological_process +def: "Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell." [GOC:dos] +is_a: GO:0007267 ! cell-cell signaling + +[Term] +id: GO:1900000 +name: regulation of anthocyanin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] +synonym: "regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of anthocyanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0031537 ! regulation of anthocyanin metabolic process +relationship: regulates GO:0046284 ! anthocyanin-containing compound catabolic process + +[Term] +id: GO:1900001 +name: negative regulation of anthocyanin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] +synonym: "down regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of anthocyanin degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of anthocyanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process +is_a: GO:1900000 ! regulation of anthocyanin catabolic process +relationship: negatively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process + +[Term] +id: GO:1900002 +name: positive regulation of anthocyanin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anthocyanin catabolic process." [GOC:TermGenie] +synonym: "positive regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of anthocyanin degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of anthocyanin breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of anthocyanin catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of anthocyanin catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of anthocyanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process +is_a: GO:1900000 ! regulation of anthocyanin catabolic process +relationship: positively_regulates GO:0046284 ! anthocyanin-containing compound catabolic process + +[Term] +id: GO:1900003 +name: regulation of serine-type endopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] +synonym: "regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] +is_a: GO:0052548 ! regulation of endopeptidase activity +is_a: GO:1902571 ! regulation of serine-type peptidase activity + +[Term] +id: GO:1900004 +name: negative regulation of serine-type endopeptidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] +synonym: "down regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] +synonym: "down regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] +is_a: GO:0010951 ! negative regulation of endopeptidase activity +is_a: GO:1900003 ! regulation of serine-type endopeptidase activity +is_a: GO:1902572 ! negative regulation of serine-type peptidase activity + +[Term] +id: GO:1900005 +name: positive regulation of serine-type endopeptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of serine-type endopeptidase activity." [GOC:TermGenie] +synonym: "positive regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] +synonym: "up regulation of blood coagulation factor activity" RELATED [GOC:TermGenie] +synonym: "up regulation of serine-type endopeptidase activity" RELATED [GOC:TermGenie] +is_a: GO:0010950 ! positive regulation of endopeptidase activity +is_a: GO:1900003 ! regulation of serine-type endopeptidase activity +is_a: GO:1902573 ! positive regulation of serine-type peptidase activity + +[Term] +id: GO:1900006 +name: positive regulation of dendrite development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendrite development." [GOC:TermGenie] +synonym: "up regulation of dendrite development" RELATED [GOC:TermGenie] +is_a: GO:0010976 ! positive regulation of neuron projection development +is_a: GO:0050773 ! regulation of dendrite development +is_a: GO:0051094 ! positive regulation of developmental process +relationship: positively_regulates GO:0016358 ! dendrite development + +[Term] +id: GO:1900007 +name: obsolete regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] +synonym: "regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900008 +name: obsolete negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] +synonym: "down regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "down regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie] +synonym: "down regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] +synonym: "negative regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "negative regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900009 +name: obsolete positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of extrachromosomal rDNA circle accumulation involved in replicative cell aging." [GOC:TermGenie, PMID:15020466] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] +synonym: "positive regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "positive regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [GOC:TermGenie] +synonym: "up regulation of extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +synonym: "up regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging" RELATED [GOC:TermGenie] +synonym: "up regulation of extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900010 +name: regulation of corticotropin-releasing hormone receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] +synonym: "regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] +synonym: "regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] +synonym: "regulation of CRF receptor activity" EXACT [GOC:TermGenie] +synonym: "regulation of CRH receptor activity" EXACT [GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:1900011 +name: negative regulation of corticotropin-releasing hormone receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] +synonym: "down regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie] +synonym: "down regulation of CRF receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CRH receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CRF receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CRH receptor activity" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:1900012 +name: positive regulation of corticotropin-releasing hormone receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity." [GOC:TermGenie, GOC:yaf, PMID:18234674] +synonym: "positive regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CRF receptor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CRH receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of adrenocorticotropin-releasing hormone receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of corticotropin-releasing factor receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of corticotropin-releasing hormone receptor activity" RELATED [GOC:TermGenie] +synonym: "up regulation of CRF receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CRH receptor activity" EXACT [GOC:TermGenie] +is_a: GO:1900010 ! regulation of corticotropin-releasing hormone receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1900013 +name: obsolete cellular response to potassium ion involved in chemotaxis to cAMP +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624] +comment: This term was made obsolete because it was added by mistake. +synonym: "cellular response to K+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to K+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to K+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] +synonym: "cellular response to K+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to K+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] +synonym: "cellular response to potassium ion involved in chemotaxis to cAMP" EXACT [] +synonym: "cellular response to potassium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to potassium of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to potassium of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] +synonym: "cellular response to potassium of chemotaxis to cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to potassium of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900014 +name: obsolete cellular response to calcium ion involved in chemotaxis to cAMP +namespace: biological_process +def: "OBSOLETE. The directed movement of a motile cell in response to the presence of 3',5'-cAMP that results in a change in state or activity (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:pf, GOC:TermGenie, PMID:19363786, PMID:21239624, PMID:8937985] +synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5' cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to Ca2+ ion of chemotaxis to 3',5'-cAMP" EXACT [GOC:TermGenie] +synonym: "cellular response to Ca2+ ion of chemotaxis to adenosine 3',5'-cyclophosphate" EXACT [GOC:TermGenie] +synonym: "cellular response to Ca2+ ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to Ca2+ ion of chemotaxis to cyclic AMP" EXACT [GOC:TermGenie] +synonym: "cellular response to calcium ion involved in chemotaxis to cAMP" EXACT [] +synonym: "cellular response to calcium ion of chemotaxis to 3',5' cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to calcium ion of chemotaxis to 3',5'-cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to calcium ion of chemotaxis to adenosine 3',5'-cyclophosphate" RELATED [GOC:TermGenie] +synonym: "cellular response to calcium ion of chemotaxis to cAMP" RELATED [GOC:TermGenie] +synonym: "cellular response to calcium ion of chemotaxis to cyclic AMP" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900015 +name: regulation of cytokine production involved in inflammatory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] +synonym: "regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0002534 ! cytokine production involved in inflammatory response + +[Term] +id: GO:1900016 +name: negative regulation of cytokine production involved in inflammatory response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] +synonym: "down regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] +synonym: "down regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] +synonym: "negative regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response +relationship: negatively_regulates GO:0002534 ! cytokine production involved in inflammatory response + +[Term] +id: GO:1900017 +name: positive regulation of cytokine production involved in inflammatory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response." [GOC:TermGenie] +synonym: "positive regulation of cytokine production involved in acute inflammatory response" NARROW [GOC:TermGenie] +synonym: "up regulation of cytokine production involved in acute inflammatory response" BROAD [GOC:TermGenie] +synonym: "up regulation of cytokine production involved in inflammatory response" RELATED [GOC:TermGenie] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1900015 ! regulation of cytokine production involved in inflammatory response +relationship: positively_regulates GO:0002534 ! cytokine production involved in inflammatory response + +[Term] +id: GO:1900018 +name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex +namespace: biological_process +def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex." [GOC:rb, GOC:TermGenie, PMID:10594013, PMID:19666497] +is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues +relationship: part_of GO:0036031 ! recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex + +[Term] +id: GO:1900019 +name: regulation of protein kinase C activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie] +synonym: "regulation of PKC" RELATED [GOC:TermGenie] +synonym: "regulation of PKC activity" EXACT [GOC:TermGenie] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:1900020 +name: positive regulation of protein kinase C activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase C activity." [GOC:signaling, GOC:TermGenie] +synonym: "positive regulation of PKC" RELATED [GOC:TermGenie] +synonym: "positive regulation of PKC activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PKC" RELATED [GOC:TermGenie] +synonym: "up regulation of PKC activity" EXACT [GOC:TermGenie] +is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity +is_a: GO:1900019 ! regulation of protein kinase C activity + +[Term] +id: GO:1900022 +name: regulation of D-erythro-sphingosine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie] +synonym: "regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:1900023 +name: positive regulation of D-erythro-sphingosine kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of D-erythro-sphingosine kinase activity." [GOC:signaling, GOC:TermGenie] +synonym: "positive regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of D-erythro-sphingosine kinase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of sphingosine kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:1900022 ! regulation of D-erythro-sphingosine kinase activity + +[Term] +id: GO:1900024 +name: regulation of substrate adhesion-dependent cell spreading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] +synonym: "regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: regulates GO:0034446 ! substrate adhesion-dependent cell spreading + +[Term] +id: GO:1900025 +name: negative regulation of substrate adhesion-dependent cell spreading +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] +synonym: "down regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] +synonym: "down regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie] +synonym: "negative regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] +synonym: "negative regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] +is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation +is_a: GO:0010812 ! negative regulation of cell-substrate adhesion +is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading +relationship: negatively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading + +[Term] +id: GO:1900026 +name: positive regulation of substrate adhesion-dependent cell spreading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading." [GOC:TermGenie, GOC:yaf] +synonym: "positive regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] +synonym: "positive regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] +synonym: "up regulation of cell spreading during cell substrate adhesion" EXACT [GOC:TermGenie] +synonym: "up regulation of substrate adhesion dependent cell spreading" EXACT [GOC:TermGenie] +synonym: "up regulation of substrate adhesion-dependent cell spreading" RELATED [GOC:TermGenie] +is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0010811 ! positive regulation of cell-substrate adhesion +is_a: GO:1900024 ! regulation of substrate adhesion-dependent cell spreading +relationship: positively_regulates GO:0034446 ! substrate adhesion-dependent cell spreading + +[Term] +id: GO:1900027 +name: regulation of ruffle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of membrane ruffle formation" EXACT [GOC:TermGenie] +synonym: "regulation of membrane ruffling" EXACT [GOC:TermGenie] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0097178 ! ruffle assembly + +[Term] +id: GO:1900028 +name: negative regulation of ruffle assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of membrane ruffle formation" EXACT [GOC:TermGenie] +synonym: "down regulation of membrane ruffling" EXACT [GOC:TermGenie] +synonym: "down regulation of ruffle assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of membrane ruffle formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of membrane ruffling" EXACT [GOC:TermGenie] +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +is_a: GO:1900027 ! regulation of ruffle assembly +relationship: negatively_regulates GO:0097178 ! ruffle assembly + +[Term] +id: GO:1900029 +name: positive regulation of ruffle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ruffle assembly." [GOC:TermGenie, GOC:yaf] +synonym: "positive regulation of membrane ruffle formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of membrane ruffling" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane ruffle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane ruffling" EXACT [GOC:TermGenie] +synonym: "up regulation of ruffle assembly" RELATED [GOC:TermGenie] +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:1900027 ! regulation of ruffle assembly +relationship: positively_regulates GO:0097178 ! ruffle assembly + +[Term] +id: GO:1900030 +name: regulation of pectin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pectin biosynthetic process." [GOC:TermGenie] +synonym: "regulation of pectin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of pectin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of pectin formation" EXACT [GOC:TermGenie] +synonym: "regulation of pectin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0045489 ! pectin biosynthetic process + +[Term] +id: GO:1900031 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling +namespace: biological_process +def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036] +synonym: "global transcription regulation from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium signalling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of calcium-mediated signalling" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0006357 +consider: GO:0019722 + +[Term] +id: GO:1900032 +name: regulation of trichome patterning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trichome patterning." [GOC:TermGenie] +synonym: "regulation of trichome distribution" BROAD [GOC:TermGenie] +synonym: "regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "regulation of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "regulation of trichome spacing" EXACT [GOC:TermGenie] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048629 ! trichome patterning + +[Term] +id: GO:1900033 +name: negative regulation of trichome patterning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of trichome patterning." [GOC:TermGenie] +synonym: "down regulation of trichome distribution" BROAD [GOC:TermGenie] +synonym: "down regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "down regulation of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "down regulation of trichome patterning" RELATED [GOC:TermGenie] +synonym: "down regulation of trichome spacing" EXACT [GOC:TermGenie] +synonym: "down-regulation of trichome distribution" BROAD [GOC:TermGenie] +synonym: "down-regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "down-regulation of trichome patterning" RELATED [GOC:TermGenie] +synonym: "down-regulation of trichome spacing" EXACT [GOC:TermGenie] +synonym: "downregulation of trichome distribution" BROAD [GOC:TermGenie] +synonym: "downregulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "downregulation of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "downregulation of trichome patterning" RELATED [GOC:TermGenie] +synonym: "downregulation of trichome spacing" EXACT [GOC:TermGenie] +synonym: "inhibition of trichome distribution" BROAD [GOC:TermGenie] +synonym: "inhibition of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "inhibition of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "inhibition of trichome patterning" RELATED [GOC:TermGenie] +synonym: "inhibition of trichome spacing" EXACT [GOC:TermGenie] +synonym: "negative regulation of trichome distribution" BROAD [GOC:TermGenie] +synonym: "negative regulation of trichome pattern biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of trichome pattern formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of trichome pattern specification" RELATED [GOC:TermGenie] +synonym: "negative regulation of trichome spacing" EXACT [GOC:TermGenie] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1900032 ! regulation of trichome patterning +relationship: negatively_regulates GO:0048629 ! trichome patterning + +[Term] +id: GO:1900034 +name: regulation of cellular response to heat +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0034605 ! cellular response to heat + +[Term] +id: GO:1900035 +name: negative regulation of cellular response to heat +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "down regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900034 ! regulation of cellular response to heat +relationship: negatively_regulates GO:0034605 ! cellular response to heat + +[Term] +id: GO:1900036 +name: positive regulation of cellular response to heat +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to heat." [GOC:TermGenie, GOC:yaf] +synonym: "activation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "activation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular response to heat stress" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to heat" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular response to heat stress" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900034 ! regulation of cellular response to heat +relationship: positively_regulates GO:0034605 ! cellular response to heat + +[Term] +id: GO:1900037 +name: regulation of cellular response to hypoxia +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:1900038 +name: negative regulation of cellular response to hypoxia +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "down regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900037 ! regulation of cellular response to hypoxia +relationship: negatively_regulates GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:1900039 +name: positive regulation of cellular response to hypoxia +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to hypoxia." [GOC:TermGenie, GOC:yaf] +synonym: "activation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "activation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "activation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to hypoxia" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular response to hypoxic stress" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to lowered oxygen tension" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900037 ! regulation of cellular response to hypoxia +relationship: positively_regulates GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:1900043 +name: obsolete leptin-mediated signaling pathway involved in negative regulation of appetite +namespace: biological_process +def: "OBSOLETE. Any leptin-mediated signaling pathway that is involved in negative regulation of appetite." [GOC:BHF, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "adipocytokine signaling pathway of appetite suppression" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] +synonym: "adipocytokine signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway involved in negative regulation of appetite" EXACT [] +synonym: "leptin-mediated signaling pathway of appetite suppression" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of down regulation of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of down-regulation of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of downregulation of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of inhibition of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signaling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of appetite suppression" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of down regulation of appetite" EXACT [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of down-regulation of appetite" EXACT [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of downregulation of appetite" EXACT [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of inhibition of appetite" NARROW [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of negative regulation of appetite" RELATED [GOC:TermGenie] +synonym: "leptin-mediated signalling pathway of negative regulation of hunger" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900044 +name: regulation of protein K63-linked ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie] +synonym: "regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +is_a: GO:1902914 ! regulation of protein polyubiquitination +relationship: regulates GO:0070534 ! protein K63-linked ubiquitination + +[Term] +id: GO:1900045 +name: negative regulation of protein K63-linked ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie] +synonym: "down regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] +synonym: "downregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] +synonym: "inhibition of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "inhibition of protein K63-linked ubiquitination" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination +is_a: GO:1902915 ! negative regulation of protein polyubiquitination +relationship: negatively_regulates GO:0070534 ! protein K63-linked ubiquitination + +[Term] +id: GO:1900046 +name: regulation of hemostasis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemostasis." [GOC:TermGenie] +is_a: GO:0050789 ! regulation of biological process +is_a: GO:0050878 ! regulation of body fluid levels +relationship: regulates GO:0007599 ! hemostasis + +[Term] +id: GO:1900047 +name: negative regulation of hemostasis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis." [GOC:TermGenie] +synonym: "down regulation of hemostasis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemostasis" EXACT [GOC:TermGenie] +synonym: "downregulation of hemostasis" EXACT [GOC:TermGenie] +synonym: "inhibition of hemostasis" NARROW [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1900046 ! regulation of hemostasis +relationship: negatively_regulates GO:0007599 ! hemostasis + +[Term] +id: GO:1900048 +name: positive regulation of hemostasis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hemostasis." [GOC:TermGenie] +synonym: "activation of hemostasis" NARROW [GOC:TermGenie] +synonym: "up regulation of hemostasis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemostasis" EXACT [GOC:TermGenie] +synonym: "upregulation of hemostasis" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1900046 ! regulation of hemostasis +relationship: positively_regulates GO:0007599 ! hemostasis + +[Term] +id: GO:1900049 +name: regulation of histone exchange +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] +synonym: "regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "regulation of histone displacement" EXACT [GOC:TermGenie] +synonym: "regulation of histone replacement" EXACT [GOC:TermGenie] +is_a: GO:1902275 ! regulation of chromatin organization +relationship: regulates GO:0043486 ! histone exchange + +[Term] +id: GO:1900050 +name: negative regulation of histone exchange +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] +synonym: "down regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "down regulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "down regulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "down-regulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "down-regulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "downregulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "downregulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "downregulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "inhibition of histone chaperone" RELATED [GOC:TermGenie] +synonym: "inhibition of histone exchange" RELATED [GOC:TermGenie] +synonym: "inhibition of histone replacement" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "negative regulation of histone replacement" EXACT [GOC:TermGenie] +is_a: GO:1900049 ! regulation of histone exchange +is_a: GO:1905268 ! negative regulation of chromatin organization +relationship: negatively_regulates GO:0043486 ! histone exchange + +[Term] +id: GO:1900051 +name: positive regulation of histone exchange +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone exchange." [GOC:TermGenie, PMID:20332092] +synonym: "activation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "activation of histone exchange" RELATED [GOC:TermGenie] +synonym: "activation of histone replacement" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "positive regulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "up regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "up regulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "up regulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "up-regulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "up-regulation of histone replacement" EXACT [GOC:TermGenie] +synonym: "upregulation of histone chaperone" RELATED [GOC:TermGenie] +synonym: "upregulation of histone exchange" RELATED [GOC:TermGenie] +synonym: "upregulation of histone replacement" EXACT [GOC:TermGenie] +is_a: GO:1900049 ! regulation of histone exchange +is_a: GO:1905269 ! positive regulation of chromatin organization +relationship: positively_regulates GO:0043486 ! histone exchange + +[Term] +id: GO:1900052 +name: regulation of retinoic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0002138 ! retinoic acid biosynthetic process + +[Term] +id: GO:1900053 +name: negative regulation of retinoic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process +relationship: negatively_regulates GO:0002138 ! retinoic acid biosynthetic process + +[Term] +id: GO:1900054 +name: positive regulation of retinoic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "activation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "activation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of retinoic acid anabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of retinoic acid biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046136 ! positive regulation of vitamin metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1900052 ! regulation of retinoic acid biosynthetic process +relationship: positively_regulates GO:0002138 ! retinoic acid biosynthetic process + +[Term] +id: GO:1900055 +name: regulation of leaf senescence +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leaf senescence." [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0010150 ! leaf senescence + +[Term] +id: GO:1900056 +name: negative regulation of leaf senescence +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf senescence." [GOC:TermGenie] +synonym: "down regulation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "down-regulation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "downregulation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "inhibition of leaf senescence" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1900055 ! regulation of leaf senescence +relationship: negatively_regulates GO:0010150 ! leaf senescence + +[Term] +id: GO:1900057 +name: positive regulation of leaf senescence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leaf senescence." [GOC:TermGenie] +synonym: "activation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "up regulation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "up-regulation of leaf senescence" RELATED [GOC:TermGenie] +synonym: "upregulation of leaf senescence" RELATED [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1900055 ! regulation of leaf senescence +relationship: positively_regulates GO:0010150 ! leaf senescence + +[Term] +id: GO:1900058 +name: regulation of sulfate assimilation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681] +synonym: "regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "regulation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: regulates GO:0000103 ! sulfate assimilation + +[Term] +id: GO:1900059 +name: positive regulation of sulfate assimilation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sulfate assimilation." [GOC:TermGenie, PMID:7601277, PMID:7891681] +synonym: "activation of sulfate assimilation" RELATED [GOC:TermGenie] +synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "activation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "positive regulation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "up regulation of sulfate assimilation" RELATED [GOC:TermGenie] +synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "up regulation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "up-regulation of sulfate assimilation" RELATED [GOC:TermGenie] +synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "up-regulation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "upregulation of sulfate assimilation" RELATED [GOC:TermGenie] +synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +synonym: "upregulation of sulphate assimilation" EXACT [GOC:TermGenie] +synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [GOC:TermGenie] +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900058 ! regulation of sulfate assimilation +relationship: positively_regulates GO:0000103 ! sulfate assimilation + +[Term] +id: GO:1900060 +name: negative regulation of ceramide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process." [GOC:TermGenie, PMID:15302821] +synonym: "down regulation of ceramide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of ceramide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ceramide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ceramide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of ceramide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ceramide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ceramide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ceramide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ceramide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of ceramide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ceramide synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ceramide anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of ceramide biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ceramide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of ceramide formation" EXACT [GOC:TermGenie] +synonym: "inhibition of ceramide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ceramide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ceramide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ceramide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ceramide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0090155 ! negative regulation of sphingolipid biosynthetic process +is_a: GO:2000303 ! regulation of ceramide biosynthetic process +relationship: negatively_regulates GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:1900061 +name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling +namespace: biological_process +def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in calcium-mediated signaling." [GOC:TermGenie, PMID:9407035, PMID:9407036] +comment: This term was made obsolete because it represents a GO-CAM model. +synonym: "activation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signaling" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium ion signaling" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signaling" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium signalling" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium ion signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium signalling" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter of calcium-mediated signalling" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter of calcium ion signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter of calcium signalling" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter of calcium-mediated signalling" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0019722 +consider: GO:0045944 + +[Term] +id: GO:1900062 +name: obsolete regulation of replicative cell aging +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of replicative cell aging." [GOC:TermGenie, PMID:17914901] +comment: This term was obsoleted because it represents an assay, not a true biological process. +synonym: "regulation of replicative cell ageing" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900063 +name: regulation of peroxisome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953] +synonym: "regulation of peroxisome organisation" EXACT [GOC:TermGenie] +synonym: "regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007031 ! peroxisome organization + +[Term] +id: GO:1900064 +name: positive regulation of peroxisome organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peroxisome organization." [GOC:TermGenie, PMID:7500953] +synonym: "activation of peroxisome organisation" NARROW [GOC:TermGenie] +synonym: "activation of peroxisome organization" NARROW [GOC:TermGenie] +synonym: "activation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "activation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of peroxisome organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of peroxisome organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of peroxisome organization" RELATED [GOC:TermGenie] +synonym: "up regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of peroxisome organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of peroxisome organization" RELATED [GOC:TermGenie] +synonym: "up-regulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of peroxisome organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of peroxisome organization" RELATED [GOC:TermGenie] +synonym: "upregulation of peroxisome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of peroxisome-assembly ATPase activity" RELATED [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1900063 ! regulation of peroxisome organization +relationship: positively_regulates GO:0007031 ! peroxisome organization + +[Term] +id: GO:1900065 +name: regulation of ethanol catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841] +synonym: "regulation of ethanol breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of ethanol catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ethanol degradation" EXACT [GOC:TermGenie] +is_a: GO:0009894 ! regulation of catabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0006068 ! ethanol catabolic process + +[Term] +id: GO:1900066 +name: positive regulation of ethanol catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ethanol catabolic process." [GOC:TermGenie, PMID:10608811, PMID:7760841] +synonym: "activation of ethanol breakdown" NARROW [GOC:TermGenie] +synonym: "activation of ethanol catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ethanol catabolism" NARROW [GOC:TermGenie] +synonym: "activation of ethanol degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ethanol breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of ethanol catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ethanol degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of ethanol breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of ethanol catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of ethanol catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ethanol degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ethanol breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of ethanol catabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of ethanol catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ethanol degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of ethanol breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of ethanol catabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of ethanol catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ethanol degradation" EXACT [GOC:TermGenie] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900065 ! regulation of ethanol catabolic process +relationship: positively_regulates GO:0006068 ! ethanol catabolic process + +[Term] +id: GO:1900067 +name: regulation of cellular response to alkaline pH +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] +synonym: "regulation of cellular response to alkalinity" BROAD [] +synonym: "regulation of cellular response to basic pH" EXACT [GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071469 ! cellular response to alkaline pH + +[Term] +id: GO:1900068 +name: negative regulation of cellular response to alkaline pH +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alkalinity." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] +synonym: "down regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to alkalinity" RELATED [GOC:TermGenie] +synonym: "down regulation of cellular response to basic pH" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to alkalinity" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to basic pH" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to alkaline pH" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to alkalinity" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to basic pH" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to alkaline pH" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to alkalinity" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to basic pH" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to alkalinity" BROAD [] +synonym: "negative regulation of cellular response to basic pH" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900067 ! regulation of cellular response to alkaline pH +relationship: negatively_regulates GO:0071469 ! cellular response to alkaline pH + +[Term] +id: GO:1900069 +name: regulation of cellular hyperosmotic salinity response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455] +synonym: "regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] +is_a: GO:0106049 ! regulation of cellular response to osmotic stress +is_a: GO:1901000 ! regulation of response to salt stress +relationship: regulates GO:0071475 ! cellular hyperosmotic salinity response + +[Term] +id: GO:1900070 +name: negative regulation of cellular hyperosmotic salinity response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular hyperosmotic salinity response." [GOC:dgf, GOC:TermGenie, PMID:16278455] +synonym: "down regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] +synonym: "down regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular hyperosmotic salinity response" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular hyperosmotic salinity response" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to hyperosmotic salt stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to hyperosmotic salt stress" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1900069 ! regulation of cellular hyperosmotic salinity response +is_a: GO:1901001 ! negative regulation of response to salt stress +relationship: negatively_regulates GO:0071475 ! cellular hyperosmotic salinity response + +[Term] +id: GO:1900071 +name: regulation of sulfite transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099] +synonym: "regulation of sulphite transport" EXACT [GOC:TermGenie] +is_a: GO:0044070 ! regulation of anion transport +relationship: regulates GO:0000316 ! sulfite transport + +[Term] +id: GO:1900072 +name: positive regulation of sulfite transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sulfite transport." [GOC:TermGenie, PMID:10234785, PMID:10870099] +synonym: "activation of sulfite transport" NARROW [GOC:TermGenie] +synonym: "activation of sulphite transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of sulphite transport" EXACT [GOC:TermGenie] +synonym: "up regulation of sulfite transport" RELATED [GOC:TermGenie] +synonym: "up regulation of sulphite transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of sulfite transport" RELATED [GOC:TermGenie] +synonym: "up-regulation of sulphite transport" EXACT [GOC:TermGenie] +synonym: "upregulation of sulfite transport" RELATED [GOC:TermGenie] +synonym: "upregulation of sulphite transport" EXACT [GOC:TermGenie] +is_a: GO:1900071 ! regulation of sulfite transport +is_a: GO:1903793 ! positive regulation of anion transport +relationship: positively_regulates GO:0000316 ! sulfite transport + +[Term] +id: GO:1900073 +name: regulation of neuromuscular synaptic transmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] +is_a: GO:0050804 ! modulation of chemical synaptic transmission +relationship: regulates GO:0007274 ! neuromuscular synaptic transmission + +[Term] +id: GO:1900074 +name: negative regulation of neuromuscular synaptic transmission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] +synonym: "down regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "down-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "downregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "inhibition of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +is_a: GO:0050805 ! negative regulation of synaptic transmission +is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission +relationship: negatively_regulates GO:0007274 ! neuromuscular synaptic transmission + +[Term] +id: GO:1900075 +name: positive regulation of neuromuscular synaptic transmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission." [GOC:kmv, GOC:TermGenie] +synonym: "activation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "up regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "up-regulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +synonym: "upregulation of neuromuscular synaptic transmission" RELATED [GOC:TermGenie] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:1900073 ! regulation of neuromuscular synaptic transmission +relationship: positively_regulates GO:0007274 ! neuromuscular synaptic transmission + +[Term] +id: GO:1900076 +name: regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0032869 ! cellular response to insulin stimulus + +[Term] +id: GO:1900077 +name: negative regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to insulin stimulus" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900076 ! regulation of cellular response to insulin stimulus +relationship: negatively_regulates GO:0032869 ! cellular response to insulin stimulus + +[Term] +id: GO:1900078 +name: positive regulation of cellular response to insulin stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to insulin stimulus." [GOC:TermGenie, GOC:yaf] +synonym: "activation of cellular response to insulin stimulus" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to insulin stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900076 ! regulation of cellular response to insulin stimulus +relationship: positively_regulates GO:0032869 ! cellular response to insulin stimulus + +[Term] +id: GO:1900079 +name: regulation of arginine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie] +synonym: "regulation of arginine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of arginine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of arginine formation" EXACT [GOC:TermGenie] +synonym: "regulation of arginine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0000821 ! regulation of arginine metabolic process +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0006526 ! arginine biosynthetic process + +[Term] +id: GO:1900080 +name: positive regulation of arginine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process." [GOC:dgf, GOC:TermGenie] +synonym: "activation of arginine anabolism" NARROW [GOC:TermGenie] +synonym: "activation of arginine biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of arginine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of arginine formation" NARROW [GOC:TermGenie] +synonym: "activation of arginine synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of arginine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900079 ! regulation of arginine biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:0006526 ! arginine biosynthetic process + +[Term] +id: GO:1900081 +name: regulation of arginine catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie] +synonym: "regulation of arginine breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of arginine catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of arginine degradation" EXACT [GOC:TermGenie] +is_a: GO:0000821 ! regulation of arginine metabolic process +is_a: GO:0033241 ! regulation of cellular amine catabolic process +relationship: regulates GO:0006527 ! arginine catabolic process + +[Term] +id: GO:1900082 +name: negative regulation of arginine catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process." [GOC:dgf, GOC:TermGenie] +synonym: "down regulation of arginine breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of arginine catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of arginine catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of arginine degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of arginine breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of arginine catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of arginine catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of arginine degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of arginine breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of arginine catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of arginine catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of arginine degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of arginine breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of arginine catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of arginine catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of arginine degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of arginine breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of arginine catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of arginine degradation" EXACT [GOC:TermGenie] +is_a: GO:0033242 ! negative regulation of cellular amine catabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1900081 ! regulation of arginine catabolic process +relationship: negatively_regulates GO:0006527 ! arginine catabolic process + +[Term] +id: GO:1900083 +name: obsolete regulation of Sertoli cell proliferation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Sertoli cell proliferation." [GOC:pr, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of Sertoli cell proliferation" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900084 +name: regulation of peptidyl-tyrosine autophosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] +synonym: "regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0031952 ! regulation of protein autophosphorylation +is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation +relationship: regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation + +[Term] +id: GO:1900085 +name: negative regulation of peptidyl-tyrosine autophosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] +synonym: "down regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "down regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "down-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "downregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine autophosphorylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0031953 ! negative regulation of protein autophosphorylation +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation +relationship: negatively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation + +[Term] +id: GO:1900086 +name: positive regulation of peptidyl-tyrosine autophosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptidyl-tyrosine autophosphorylation." [GOC:bf, GOC:TermGenie] +synonym: "activation of peptidyl-tyrosine autophosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of tyrosine autophosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "up regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "up-regulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-tyrosine autophosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor tyrosine kinase autophosphorylation" NARROW [GOC:TermGenie] +synonym: "upregulation of tyrosine autophosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0031954 ! positive regulation of protein autophosphorylation +is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation +is_a: GO:1900084 ! regulation of peptidyl-tyrosine autophosphorylation +relationship: positively_regulates GO:0038083 ! peptidyl-tyrosine autophosphorylation + +[Term] +id: GO:1900087 +name: positive regulation of G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] +synonym: "activation of G1/S transition of mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "up regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition +is_a: GO:1902808 ! positive regulation of cell cycle G1/S phase transition +is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle +relationship: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:1900088 +name: regulation of inositol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0006021 ! inositol biosynthetic process + +[Term] +id: GO:1900089 +name: negative regulation of inositol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "down regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of inositol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900088 ! regulation of inositol biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0006021 ! inositol biosynthetic process + +[Term] +id: GO:1900090 +name: positive regulation of inositol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inositol biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "activation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of inositol formation" EXACT [GOC:TermGenie] +synonym: "activation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "activation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of myo-inositol biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of myo-inositol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of vitamin Bh biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin Bh biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900088 ! regulation of inositol biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0006021 ! inositol biosynthetic process + +[Term] +id: GO:1900091 +name: regulation of raffinose biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "regulation of raffinose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +is_a: GO:0080091 ! regulation of raffinose metabolic process +relationship: regulates GO:0033529 ! raffinose biosynthetic process + +[Term] +id: GO:1900092 +name: negative regulation of raffinose biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "down regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "down regulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "downregulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of raffinose biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of raffinose formation" EXACT [GOC:TermGenie] +synonym: "inhibition of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of raffinose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:1900091 ! regulation of raffinose biosynthetic process +relationship: negatively_regulates GO:0033529 ! raffinose biosynthetic process + +[Term] +id: GO:1900093 +name: positive regulation of raffinose biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of raffinose biosynthetic process." [GOC:TermGenie, PMID:22307851] +synonym: "activation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "activation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of raffinose biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "activation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "up regulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of raffinose synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of raffinose anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of raffinose biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of raffinose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of raffinose formation" EXACT [GOC:TermGenie] +synonym: "upregulation of raffinose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:1900091 ! regulation of raffinose biosynthetic process +relationship: positively_regulates GO:0033529 ! raffinose biosynthetic process + +[Term] +id: GO:1900094 +name: regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry +namespace: biological_process +def: "Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry." [GOC:BHF, GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of determination of left/right asymmetry" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter of determination of left/right symmetry" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry" RELATED [GOC:TermGenie] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: part_of GO:0007368 ! determination of left/right symmetry + +[Term] +id: GO:1900095 +name: regulation of dosage compensation by inactivation of X chromosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:mr, GOC:TermGenie, PMID:20622855, Wikipedia:XY_sex-determination_system] +synonym: "regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +is_a: GO:0010468 ! regulation of gene expression +relationship: regulates GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:1900096 +name: negative regulation of dosage compensation by inactivation of X chromosome +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie] +synonym: "down regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "down regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "down regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "down regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "down-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "downregulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "downregulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "downregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "downregulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "inhibition of Barr body formation" RELATED [GOC:TermGenie] +synonym: "inhibition of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "inhibition of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie] +synonym: "inhibition of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "negative regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome +relationship: negatively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:1900097 +name: positive regulation of dosage compensation by inactivation of X chromosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." [GOC:TermGenie] +synonym: "activation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "activation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "activation of dosage compensation, by inactivation of X chromosome" NARROW [GOC:TermGenie] +synonym: "activation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "positive regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "up regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "up regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "up regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "up regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "up-regulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of X chromosome inactivation" EXACT [GOC:TermGenie] +synonym: "upregulation of Barr body formation" RELATED [GOC:TermGenie] +synonym: "upregulation of chromosome inactivation" BROAD [GOC:TermGenie] +synonym: "upregulation of dosage compensation, by inactivation of X chromosome" EXACT [GOC:TermGenie] +synonym: "upregulation of X chromosome inactivation" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1900095 ! regulation of dosage compensation by inactivation of X chromosome +relationship: positively_regulates GO:0009048 ! dosage compensation by inactivation of X chromosome + +[Term] +id: GO:1900098 +name: regulation of plasma cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] +synonym: "regulation of plasma cell development" RELATED [GOC:TermGenie] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0045577 ! regulation of B cell differentiation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002317 ! plasma cell differentiation + +[Term] +id: GO:1900099 +name: negative regulation of plasma cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] +synonym: "down regulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "down regulation of plasma cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "down-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "downregulation of plasma cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of plasma cell development" RELATED [GOC:TermGenie] +synonym: "inhibition of plasma cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of plasma cell development" RELATED [GOC:TermGenie] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0045578 ! negative regulation of B cell differentiation +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:1900098 ! regulation of plasma cell differentiation +relationship: negatively_regulates GO:0002317 ! plasma cell differentiation + +[Term] +id: GO:1900100 +name: positive regulation of plasma cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasma cell differentiation." [GOC:TermGenie] +synonym: "activation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "activation of plasma cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "up regulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "up regulation of plasma cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "up-regulation of plasma cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of plasma cell development" RELATED [GOC:TermGenie] +synonym: "upregulation of plasma cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0045579 ! positive regulation of B cell differentiation +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:1900098 ! regulation of plasma cell differentiation +relationship: positively_regulates GO:0002317 ! plasma cell differentiation + +[Term] +id: GO:1900101 +name: regulation of endoplasmic reticulum unfolded protein response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] +synonym: "regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +relationship: regulates GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:1900102 +name: negative regulation of endoplasmic reticulum unfolded protein response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "down regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "down-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of erUPR" EXACT [GOC:TermGenie] +synonym: "downregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "inhibition of erUPR" EXACT [GOC:TermGenie] +synonym: "inhibition of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "negative regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress +relationship: negatively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:1900103 +name: positive regulation of endoplasmic reticulum unfolded protein response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response." [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "activation of erUPR" EXACT [GOC:TermGenie] +synonym: "activation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "positive regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "positive regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "up regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of erUPR" EXACT [GOC:TermGenie] +synonym: "up-regulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of ER unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of erUPR" EXACT [GOC:TermGenie] +synonym: "upregulation of SREBP-mediated signalling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress +relationship: positively_regulates GO:0030968 ! endoplasmic reticulum unfolded protein response + +[Term] +id: GO:1900104 +name: regulation of hyaluranon cable assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of HA cable assembly" EXACT [GOC:TermGenie] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0036118 ! hyaluranon cable assembly + +[Term] +id: GO:1900105 +name: negative regulation of hyaluranon cable assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of hyaluranon cable assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of HA cable assembly" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1900104 ! regulation of hyaluranon cable assembly +relationship: negatively_regulates GO:0036118 ! hyaluranon cable assembly + +[Term] +id: GO:1900106 +name: positive regulation of hyaluranon cable assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly." [GOC:TermGenie, GOC:yaf] +synonym: "activation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "activation of hyaluranon cable assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of HA cable assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluranon cable assembly" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1900104 ! regulation of hyaluranon cable assembly +relationship: positively_regulates GO:0036118 ! hyaluranon cable assembly + +[Term] +id: GO:1900107 +name: regulation of nodal signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] +synonym: "regulation of nodal signaling" EXACT [GOC:TermGenie] +synonym: "regulation of nodal signalling pathway" EXACT [GOC:mah] +is_a: GO:0032925 ! regulation of activin receptor signaling pathway +relationship: regulates GO:0038092 ! nodal signaling pathway + +[Term] +id: GO:1900108 +name: negative regulation of nodal signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway." [GOC:BHF, GOC:TermGenie, GOC:vk] +synonym: "down regulation of nodal signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of nodal signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of nodal signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of nodal signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of nodal signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of nodal signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of nodal signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of nodal signalling pathway" EXACT [GOC:mah] +is_a: GO:0032926 ! negative regulation of activin receptor signaling pathway +is_a: GO:1900107 ! regulation of nodal signaling pathway +relationship: negatively_regulates GO:0038092 ! nodal signaling pathway + +[Term] +id: GO:1900109 +name: regulation of histone H3-K9 dimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] +synonym: "regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: regulates GO:0036123 ! histone H3-K9 dimethylation + +[Term] +id: GO:1900110 +name: negative regulation of histone H3-K9 dimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] +synonym: "down regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3 K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone H3-K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation +is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation +relationship: negatively_regulates GO:0036123 ! histone H3-K9 dimethylation + +[Term] +id: GO:1900111 +name: positive regulation of histone H3-K9 dimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 dimethylation." [GOC:TermGenie, GOC:vw] +synonym: "activation of histone H3 K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "activation of histone H3-K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "activation of histone lysine H3 K9 dimethylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3 K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K9 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone lysine H3 K9 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation +is_a: GO:1900109 ! regulation of histone H3-K9 dimethylation +relationship: positively_regulates GO:0036123 ! histone H3-K9 dimethylation + +[Term] +id: GO:1900112 +name: regulation of histone H3-K9 trimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] +is_a: GO:0051570 ! regulation of histone H3-K9 methylation +relationship: regulates GO:0036124 ! histone H3-K9 trimethylation + +[Term] +id: GO:1900113 +name: negative regulation of histone H3-K9 trimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] +synonym: "down regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3-K9 trimethylation" NARROW [GOC:TermGenie] +is_a: GO:0051573 ! negative regulation of histone H3-K9 methylation +is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation +relationship: negatively_regulates GO:0036124 ! histone H3-K9 trimethylation + +[Term] +id: GO:1900114 +name: positive regulation of histone H3-K9 trimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 trimethylation." [GOC:TermGenie] +synonym: "activation of histone H3-K9 trimethylation" NARROW [GOC:TermGenie] +synonym: "up regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K9 trimethylation" EXACT [GOC:TermGenie] +is_a: GO:0051574 ! positive regulation of histone H3-K9 methylation +is_a: GO:1900112 ! regulation of histone H3-K9 trimethylation +relationship: positively_regulates GO:0036124 ! histone H3-K9 trimethylation + +[Term] +id: GO:1900115 +name: extracellular regulation of signal transduction +namespace: biological_process +def: "Any regulation of signal transduction that takes place in the extracellular region." [GOC:signaling, GOC:TermGenie] +synonym: "regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] +synonym: "regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction + +[Term] +id: GO:1900116 +name: extracellular negative regulation of signal transduction +namespace: biological_process +def: "Any negative regulation of signal transduction that takes place in extracellular region." [GOC:signaling, GOC:TermGenie] +synonym: "down regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] +synonym: "down-regulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] +synonym: "downregulation of signal transduction in extracellular region" EXACT [GOC:TermGenie] +synonym: "extracellular inhibition of signaling pathway" NARROW [GOC:bf] +synonym: "inhibition of signal transduction in extracellular region" NARROW [GOC:TermGenie] +synonym: "negative regulation of signaling pathway in extracellular region" EXACT [GOC:TermGenie] +synonym: "negative regulation of signalling pathway in extracellular region" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900115 ! extracellular regulation of signal transduction + +[Term] +id: GO:1900117 +name: regulation of execution phase of apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0097194 ! execution phase of apoptosis + +[Term] +id: GO:1900118 +name: negative regulation of execution phase of apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "down regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of execution phase of apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:1900117 ! regulation of execution phase of apoptosis +relationship: negatively_regulates GO:0097194 ! execution phase of apoptosis + +[Term] +id: GO:1900119 +name: positive regulation of execution phase of apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis." [GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "activation of execution phase of apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of execution phase of apoptosis" EXACT [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:1900117 ! regulation of execution phase of apoptosis +relationship: positively_regulates GO:0097194 ! execution phase of apoptosis + +[Term] +id: GO:1900120 +name: regulation of receptor binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] +synonym: "regulation of receptor ligand" NARROW [GOC:TermGenie] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:1900121 +name: negative regulation of receptor binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] +synonym: "down regulation of receptor binding" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor-associated protein activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor binding" EXACT [GOC:TermGenie] +synonym: "inhibition of receptor binding" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor ligand" NARROW [GOC:TermGenie] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1900122 +name: positive regulation of receptor binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor." [GOC:signaling, GOC:TermGenie] +synonym: "activation of receptor binding" NARROW [GOC:TermGenie] +synonym: "up regulation of receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor binding" EXACT [GOC:TermGenie] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1900123 +name: regulation of nodal receptor complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104] +synonym: "regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0038099 ! nodal receptor complex assembly + +[Term] +id: GO:1900124 +name: negative regulation of nodal receptor complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nodal receptor complex assembly." [GOC:signaling, GOC:TermGenie, PMID:15062104] +synonym: "down regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal receptor complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal receptor complex formation" EXACT [GOC:TermGenie] +synonym: "inhibition of ActRIIB.ALK4.EGF-CFC complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of nodal receptor complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of nodal receptor complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of ActRIIB.ALK4.EGF-CFC complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of nodal receptor complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1900123 ! regulation of nodal receptor complex assembly +relationship: negatively_regulates GO:0038099 ! nodal receptor complex assembly + +[Term] +id: GO:1900125 +name: regulation of hyaluronan biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0030213 ! hyaluronan biosynthetic process + +[Term] +id: GO:1900126 +name: negative regulation of hyaluronan biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "down regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "downregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "inhibition of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process +relationship: negatively_regulates GO:0030213 ! hyaluronan biosynthetic process + +[Term] +id: GO:1900127 +name: positive regulation of hyaluronan biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process." [GOC:TermGenie, GOC:yaf] +synonym: "activation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "activation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of hyaluronan biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "activation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "up regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluronan anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluronan biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluronan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluronan formation" EXACT [GOC:TermGenie] +synonym: "upregulation of hyaluronan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900125 ! regulation of hyaluronan biosynthetic process +relationship: positively_regulates GO:0030213 ! hyaluronan biosynthetic process + +[Term] +id: GO:1900128 +name: regulation of G-protein activated inward rectifier potassium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie] +synonym: "regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity + +[Term] +id: GO:1900129 +name: positive regulation of G-protein activated inward rectifier potassium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G-protein activated inward rectifier potassium channel activity." [GOC:TermGenie] +synonym: "activation of G protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of G protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of G-protein activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of G-protein enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of G-protein-activated inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of G-protein-enhanced inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein-activated inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein-enhanced inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1900128 ! regulation of G-protein activated inward rectifier potassium channel activity +is_a: GO:1901980 ! positive regulation of inward rectifier potassium channel activity + +[Term] +id: GO:1900130 +name: regulation of lipid binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1900131 +name: negative regulation of lipid binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] +synonym: "down regulation of lipid binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipid binding" EXACT [GOC:TermGenie] +synonym: "downregulation of lipid binding" EXACT [GOC:TermGenie] +synonym: "inhibition of lipid binding" NARROW [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1900130 ! regulation of lipid binding + +[Term] +id: GO:1900132 +name: positive regulation of lipid binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lipid binding." [GOC:pm, GOC:TermGenie] +synonym: "activation of lipid binding" NARROW [GOC:TermGenie] +synonym: "up regulation of lipid binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipid binding" EXACT [GOC:TermGenie] +synonym: "upregulation of lipid binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1900130 ! regulation of lipid binding + +[Term] +id: GO:1900133 +name: regulation of renin secretion into blood stream +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] +synonym: "regulation of renin release into blood stream" EXACT [GOC:TermGenie] +is_a: GO:0003073 ! regulation of systemic arterial blood pressure +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0050708 ! regulation of protein secretion +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0002001 ! renin secretion into blood stream + +[Term] +id: GO:1900134 +name: negative regulation of renin secretion into blood stream +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] +synonym: "down regulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "down regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +synonym: "down-regulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "down-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +synonym: "downregulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "downregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +synonym: "inhibition of renin release into blood stream" NARROW [GOC:TermGenie] +synonym: "inhibition of renin secretion into blood stream" NARROW [GOC:TermGenie] +synonym: "negative regulation of renin release into blood stream" EXACT [GOC:TermGenie] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:1900133 ! regulation of renin secretion into blood stream +relationship: negatively_regulates GO:0002001 ! renin secretion into blood stream + +[Term] +id: GO:1900135 +name: positive regulation of renin secretion into blood stream +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of renin secretion into blood stream." [GOC:TermGenie] +synonym: "activation of renin release into blood stream" NARROW [GOC:TermGenie] +synonym: "activation of renin secretion into blood stream" NARROW [GOC:TermGenie] +synonym: "positive regulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "up regulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "up regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +synonym: "up-regulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "up-regulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +synonym: "upregulation of renin release into blood stream" EXACT [GOC:TermGenie] +synonym: "upregulation of renin secretion into blood stream" EXACT [GOC:TermGenie] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:1900133 ! regulation of renin secretion into blood stream +relationship: positively_regulates GO:0002001 ! renin secretion into blood stream + +[Term] +id: GO:1900136 +name: regulation of chemokine activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemokine activity." [GOC:TermGenie] +is_a: GO:0060300 ! regulation of cytokine activity + +[Term] +id: GO:1900137 +name: negative regulation of chemokine activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity." [GOC:TermGenie] +synonym: "down regulation of chemokine activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemokine activity" EXACT [GOC:TermGenie] +synonym: "downregulation of chemokine activity" EXACT [GOC:TermGenie] +synonym: "inhibition of chemokine activity" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0060302 ! negative regulation of cytokine activity +is_a: GO:1900136 ! regulation of chemokine activity + +[Term] +id: GO:1900138 +name: negative regulation of phospholipase A2 activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity." [GOC:TermGenie] +synonym: "down regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of lecithinase A activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phospholipase A" RELATED [GOC:TermGenie] +synonym: "down regulation of phospholipase A2 activity" EXACT [GOC:TermGenie] +synonym: "down regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of lecithinase A activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipase A" RELATED [GOC:TermGenie] +synonym: "down-regulation of phospholipase A2 activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of lecithinase A activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of phosphatidolipase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipase A" RELATED [GOC:TermGenie] +synonym: "downregulation of phospholipase A2 activity" EXACT [GOC:TermGenie] +synonym: "downregulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of lecithinase A activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of phosphatidolipase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylcholine 2-acylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phospholipase A" RELATED [GOC:TermGenie] +synonym: "inhibition of phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytosolic phospholipase A2 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of lecithinase A activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of phosphatidolipase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylcholine 2-acylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phospholipase A" RELATED [GOC:TermGenie] +synonym: "negative regulation of secreted phospholipase A2 activity" NARROW [GOC:TermGenie] +is_a: GO:0010519 ! negative regulation of phospholipase activity +is_a: GO:0032429 ! regulation of phospholipase A2 activity + +[Term] +id: GO:1900139 +name: negative regulation of arachidonic acid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of arachidonic acid secretion." [GOC:TermGenie] +synonym: "down regulation of arachidonic acid secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of arachidonic acid secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of arachidonic acid secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of arachidonic acid secretion" NARROW [GOC:TermGenie] +is_a: GO:0032304 ! negative regulation of icosanoid secretion +is_a: GO:0090237 ! regulation of arachidonic acid secretion +relationship: negatively_regulates GO:0050482 ! arachidonic acid secretion + +[Term] +id: GO:1900140 +name: regulation of seedling development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seedling development." [GOC:TermGenie] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0090351 ! seedling development + +[Term] +id: GO:1900141 +name: regulation of oligodendrocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0034350 ! regulation of glial cell apoptotic process +relationship: regulates GO:0097252 ! oligodendrocyte apoptotic process + +[Term] +id: GO:1900142 +name: negative regulation of oligodendrocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] +synonym: "down regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0034351 ! negative regulation of glial cell apoptotic process +is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process +relationship: negatively_regulates GO:0097252 ! oligodendrocyte apoptotic process + +[Term] +id: GO:1900143 +name: positive regulation of oligodendrocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process." [GOC:TermGenie, GOC:yaf] +synonym: "activation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of oligodendrocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of oligodendrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of oligodendrocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0034352 ! positive regulation of glial cell apoptotic process +is_a: GO:1900141 ! regulation of oligodendrocyte apoptotic process +relationship: positively_regulates GO:0097252 ! oligodendrocyte apoptotic process + +[Term] +id: GO:1900144 +name: positive regulation of BMP secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of BMP secretion." [GOC:sart, GOC:TermGenie] +synonym: "activation of BMP protein secretion" NARROW [GOC:TermGenie] +synonym: "activation of BMP secretion" NARROW [GOC:TermGenie] +synonym: "activation of bone morphogenetic protein secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of BMP protein secretion" EXACT [GOC:TermGenie] +synonym: "positive regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP protein secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP protein secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP protein secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of bone morphogenetic protein secretion" EXACT [GOC:TermGenie] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:2001284 ! regulation of BMP secretion +relationship: positively_regulates GO:0038055 ! BMP secretion + +[Term] +id: GO:1900145 +name: regulation of nodal signaling pathway involved in determination of left/right asymmetry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] +synonym: "regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:1900107 ! regulation of nodal signaling pathway +relationship: regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry + +[Term] +id: GO:1900146 +name: negative regulation of nodal signaling pathway involved in determination of left/right asymmetry +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry." [GOC:BHF, GOC:signaling, GOC:TermGenie, GOC:vk] +synonym: "down regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "down-regulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "inhibition of nodal signaling pathway involved in determination of left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "negative regulation of nodal signalling pathway involved in determination of left/right asymmetry" EXACT [GOC:mah] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1900108 ! negative regulation of nodal signaling pathway +is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry +relationship: negatively_regulates GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry + +[Term] +id: GO:1900147 +name: regulation of Schwann cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] +is_a: GO:1903975 ! regulation of glial cell migration +relationship: regulates GO:0036135 ! Schwann cell migration + +[Term] +id: GO:1900148 +name: negative regulation of Schwann cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] +synonym: "down regulation of Schwann cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of Schwann cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of Schwann cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of Schwann cell migration" NARROW [GOC:TermGenie] +is_a: GO:1900147 ! regulation of Schwann cell migration +is_a: GO:1903976 ! negative regulation of glial cell migration +relationship: negatively_regulates GO:0036135 ! Schwann cell migration + +[Term] +id: GO:1900149 +name: positive regulation of Schwann cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Schwann cell migration." [GOC:sjw, GOC:TermGenie] +synonym: "activation of Schwann cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of Schwann cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of Schwann cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of Schwann cell migration" EXACT [GOC:TermGenie] +is_a: GO:1900147 ! regulation of Schwann cell migration +is_a: GO:1903977 ! positive regulation of glial cell migration +relationship: positively_regulates GO:0036135 ! Schwann cell migration + +[Term] +id: GO:1900150 +name: regulation of defense response to fungus +namespace: biological_process +alt_id: GO:2000072 +def: "Any process that modulates the frequency, rate or extent of defense response to fungus." [GOC:dhl, GOC:TermGenie, PMID:22242006] +synonym: "regulation of defence response to fungi" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to fungus" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to fungi" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to fungi, incompatible interaction" NARROW [GOC:obol] +synonym: "regulation of defense response to fungus, incompatible interaction" NARROW [] +synonym: "regulation of resistance response to pathogenic fungi" NARROW [GOC:obol] +synonym: "regulation of resistance response to pathogenic fungus" NARROW [GOC:obol] +synonym: "regulation of response to pathogenic fungus (incompatible interaction)" NARROW [GOC:obol] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0050832 ! defense response to fungus + +[Term] +id: GO:1900151 +name: regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] +synonym: "regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0043488 ! regulation of mRNA stability +relationship: regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:1900152 +name: negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] +synonym: "down regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "downregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "inhibition of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "negative regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +is_a: GO:1902373 ! negative regulation of mRNA catabolic process +relationship: negatively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:1900153 +name: positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay." [GOC:mcc, GOC:TermGenie] +synonym: "activation of deadenylation-dependent mRNA decay" NARROW [GOC:TermGenie] +synonym: "activation of mRNA breakdown, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "activation of mRNA catabolic process, deadenylation-dependent" NARROW [GOC:TermGenie] +synonym: "activation of mRNA catabolic process, deadenylylation-dependent" NARROW [GOC:TermGenie] +synonym: "activation of mRNA catabolism, deadenylation-dependent" NARROW [GOC:TermGenie] +synonym: "activation of mRNA catabolism, deadenylylation-dependent" NARROW [GOC:TermGenie] +synonym: "activation of mRNA degradation, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "activation of nuclear mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "activation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" NARROW [GOC:TermGenie] +synonym: "positive regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "positive regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up-regulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "upregulation of deadenylation-dependent mRNA decay" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA breakdown, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA catabolic process, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA catabolic process, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA catabolism, deadenylation-dependent" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA catabolism, deadenylylation-dependent" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA degradation, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" EXACT [GOC:TermGenie] +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:1900151 ! regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay +relationship: positively_regulates GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay + +[Term] +id: GO:1900154 +name: regulation of bone trabecula formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060346 ! bone trabecula formation + +[Term] +id: GO:1900155 +name: negative regulation of bone trabecula formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "down regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "down regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "down regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "downregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "downregulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "inhibition of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of bone trabecula formation" NARROW [GOC:TermGenie] +synonym: "inhibition of bone trabeculation" NARROW [GOC:TermGenie] +synonym: "inhibition of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of skeletal trabecula formation" NARROW [GOC:TermGenie] +synonym: "inhibition of skeletal trabeculation" NARROW [GOC:TermGenie] +synonym: "negative regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "negative regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1900154 ! regulation of bone trabecula formation +relationship: negatively_regulates GO:0060346 ! bone trabecula formation + +[Term] +id: GO:1900156 +name: positive regulation of bone trabecula formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone trabecula formation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "activation of bone trabecula formation" NARROW [GOC:TermGenie] +synonym: "activation of bone trabeculation" NARROW [GOC:TermGenie] +synonym: "activation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "activation of skeletal trabecula formation" NARROW [GOC:TermGenie] +synonym: "activation of skeletal trabeculation" NARROW [GOC:TermGenie] +synonym: "positive regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "positive regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "up regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "up regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "up regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "up regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal trabeculation" EXACT [GOC:TermGenie] +synonym: "upregulation of bone trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of bone trabecula formation" EXACT [GOC:TermGenie] +synonym: "upregulation of bone trabeculation" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal trabecula biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of skeletal trabecula formation" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal trabeculation" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1900154 ! regulation of bone trabecula formation +relationship: positively_regulates GO:0060346 ! bone trabecula formation + +[Term] +id: GO:1900157 +name: regulation of bone mineralization involved in bone maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] +is_a: GO:0030500 ! regulation of bone mineralization +relationship: regulates GO:0035630 ! bone mineralization involved in bone maturation + +[Term] +id: GO:1900158 +name: negative regulation of bone mineralization involved in bone maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] +is_a: GO:0030502 ! negative regulation of bone mineralization +is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation +relationship: negatively_regulates GO:0035630 ! bone mineralization involved in bone maturation + +[Term] +id: GO:1900159 +name: positive regulation of bone mineralization involved in bone maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of bone mineralization involved in bone maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of bone mineralization involved in bone maturation" EXACT [GOC:TermGenie] +is_a: GO:0030501 ! positive regulation of bone mineralization +is_a: GO:1900157 ! regulation of bone mineralization involved in bone maturation +relationship: positively_regulates GO:0035630 ! bone mineralization involved in bone maturation + +[Term] +id: GO:1900160 +name: plastid DNA packaging +namespace: biological_process +def: "Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure." [GOC:emb, GOC:TermGenie, PMID:12081370] +synonym: "DNA organisation in plastid" EXACT [GOC:TermGenie] +synonym: "DNA organization in plastid" EXACT [GOC:TermGenie] +synonym: "plastidial DNA packaging" EXACT [GOC:emb] +is_a: GO:0036385 ! nucleoid DNA packaging + +[Term] +id: GO:1900161 +name: regulation of phospholipid scramblase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] +is_a: GO:0061091 ! regulation of phospholipid translocation +is_a: GO:0110112 ! regulation of lipid transporter activity +is_a: GO:1903729 ! regulation of plasma membrane organization + +[Term] +id: GO:1900162 +name: negative regulation of phospholipid scramblase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] +synonym: "down regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of phospholipid scramblase activity" NARROW [GOC:TermGenie] +is_a: GO:0061093 ! negative regulation of phospholipid translocation +is_a: GO:0110114 ! negative regulation of lipid transporter activity +is_a: GO:1900161 ! regulation of phospholipid scramblase activity + +[Term] +id: GO:1900163 +name: positive regulation of phospholipid scramblase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipid scramblase activity." [GOC:TermGenie] +synonym: "activation of phospholipid scramblase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipid scramblase activity" EXACT [GOC:TermGenie] +is_a: GO:0110113 ! positive regulation of lipid transporter activity +is_a: GO:1900161 ! regulation of phospholipid scramblase activity + +[Term] +id: GO:1900164 +name: nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of lateral mesoderm with respect to the left and right halves." [GOC:BHF, GOC:TermGenie, GOC:vk] +synonym: "nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] +is_a: GO:0038107 ! nodal signaling pathway involved in determination of left/right asymmetry +relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm + +[Term] +id: GO:1900166 +name: regulation of glial cell-derived neurotrophic factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf] +synonym: "regulation of GDNF secretion" NARROW [GOC:TermGenie] +synonym: "regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] +synonym: "regulation of glial cell-derived neurotrophic factor secretion" NARROW [] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0044467 ! glial cell-derived neurotrophic factor production + +[Term] +id: GO:1900167 +name: negative regulation of glial cell-derived neurotrophic factor production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf] +synonym: "inhibition of GDNF secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of GDNF secretion" EXACT [GOC:TermGenie] +synonym: "negative regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] +synonym: "negative regulation of glial cell-derived neurotrophic factor secretion" NARROW [] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor production +relationship: negatively_regulates GO:0044467 ! glial cell-derived neurotrophic factor production + +[Term] +id: GO:1900168 +name: positive regulation of glial cell-derived neurotrophic factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor production." [GOC:TermGenie, GOC:yaf] +synonym: "activation of glial cell line-derived neurotrophic factor secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of GDNF production" EXACT [GOC:TermGenie] +synonym: "positive regulation of glial cell line-derived neurotrophic factor secretion" RELATED [] +synonym: "positive regulation of glial cell-derived neurotrophic factor secretion" NARROW [] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1900166 ! regulation of glial cell-derived neurotrophic factor production +relationship: positively_regulates GO:0044467 ! glial cell-derived neurotrophic factor production + +[Term] +id: GO:1900169 +name: regulation of glucocorticoid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] +synonym: "regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0043402 ! glucocorticoid mediated signaling pathway + +[Term] +id: GO:1900170 +name: negative regulation of glucocorticoid mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] +synonym: "down regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "downregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "inhibition of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of glucocorticoid mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway +relationship: negatively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway + +[Term] +id: GO:1900171 +name: positive regulation of glucocorticoid mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway." [GOC:TermGenie] +synonym: "activation of glucocorticoid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of glucocorticoid mediated signalling" NARROW [GOC:TermGenie] +synonym: "positive regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "up regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +synonym: "upregulation of glucocorticoid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of glucocorticoid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900169 ! regulation of glucocorticoid mediated signaling pathway +relationship: positively_regulates GO:0043402 ! glucocorticoid mediated signaling pathway + +[Term] +id: GO:1900175 +name: regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk] +synonym: "regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] +is_a: GO:1900145 ! regulation of nodal signaling pathway involved in determination of left/right asymmetry +relationship: regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1900176 +name: negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry in the lateral mesoderm." [GOC:BHF, GOC:TermGenie, GOC:vk, PMID:15084459] +synonym: "down-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "downregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "inhibition of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "negative regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] +is_a: GO:1900146 ! negative regulation of nodal signaling pathway involved in determination of left/right asymmetry +is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +relationship: negatively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1900177 +name: regulation of aflatoxin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] +synonym: "regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0045122 ! aflatoxin biosynthetic process + +[Term] +id: GO:1900178 +name: negative regulation of aflatoxin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] +synonym: "down regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of aflatoxin anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aflatoxin biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of aflatoxin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aflatoxin formation" NARROW [GOC:TermGenie] +synonym: "inhibition of aflatoxin synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0045122 ! aflatoxin biosynthetic process + +[Term] +id: GO:1900179 +name: positive regulation of aflatoxin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process." [GOC:di] +synonym: "activation of aflatoxin anabolism" NARROW [GOC:TermGenie] +synonym: "activation of aflatoxin biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of aflatoxin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of aflatoxin formation" NARROW [GOC:TermGenie] +synonym: "activation of aflatoxin synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of aflatoxin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aflatoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of aflatoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aflatoxin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of aflatoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900177 ! regulation of aflatoxin biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0045122 ! aflatoxin biosynthetic process + +[Term] +id: GO:1900180 +name: regulation of protein localization to nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] +synonym: "regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1900181 +name: negative regulation of protein localization to nucleus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] +synonym: "down regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to nucleus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to nucleus" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to nucleus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in cell nucleus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in nucleus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to nucleus" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1900180 ! regulation of protein localization to nucleus +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1900182 +name: positive regulation of protein localization to nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleus." [GOC:TermGenie] +synonym: "activation of protein localisation to nucleus" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in cell nucleus" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "activation of protein localization to nucleus" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to nucleus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to nucleus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to nucleus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in cell nucleus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in nucleus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to nucleus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1900180 ! regulation of protein localization to nucleus +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1900183 +name: regulation of xanthone-containing compound biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +relationship: regulates GO:2001307 ! xanthone-containing compound biosynthetic process + +[Term] +id: GO:1900184 +name: negative regulation of xanthone-containing compound biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "down regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "downregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "inhibition of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of xanthones anabolism" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process +relationship: negatively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process + +[Term] +id: GO:1900185 +name: positive regulation of xanthone-containing compound biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xanthone-containing compound biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "activation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of xanthone-containing compound biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "activation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "up regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of xanthone biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of xanthone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of xanthone-containing compound anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of xanthone-containing compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of xanthone-containing compound biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of xanthone-containing compound formation" EXACT [GOC:TermGenie] +synonym: "upregulation of xanthone-containing compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process +relationship: positively_regulates GO:2001307 ! xanthone-containing compound biosynthetic process + +[Term] +id: GO:1900186 +name: negative regulation of clathrin-dependent endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:TermGenie] +synonym: "down regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin-mediated endocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of clathrin-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of clathrin-mediated endocytosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of clathrin-mediated endocytosis" EXACT [] +is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis +is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis +relationship: negatively_regulates GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:1900187 +name: regulation of cell adhesion involved in single-species biofilm formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] +synonym: "regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +relationship: regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation + +[Term] +id: GO:1900188 +name: negative regulation of cell adhesion involved in single-species biofilm formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] +synonym: "down regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "down regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "downregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "downregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "inhibition of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "inhibition of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +is_a: GO:0010812 ! negative regulation of cell-substrate adhesion +is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation +relationship: negatively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation + +[Term] +id: GO:1900189 +name: positive regulation of cell adhesion involved in single-species biofilm formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell adhesion involved in single-species biofilm formation." [GOC:di, GOC:TermGenie] +synonym: "activation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "activation of cell adhesion involved in single-species biofilm formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "up regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "up regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "upregulation of cell adhesion during single-species biofilm formation" RELATED [GOC:TermGenie] +synonym: "upregulation of cell adhesion involved in single-species biofilm formation" EXACT [GOC:TermGenie] +is_a: GO:0010811 ! positive regulation of cell-substrate adhesion +is_a: GO:1900187 ! regulation of cell adhesion involved in single-species biofilm formation +relationship: positively_regulates GO:0043709 ! cell adhesion involved in single-species biofilm formation + +[Term] +id: GO:1900190 +name: regulation of single-species biofilm formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0044010 ! single-species biofilm formation + +[Term] +id: GO:1900191 +name: negative regulation of single-species biofilm formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] +synonym: "down regulation of single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "downregulation of single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "inhibition of single-species biofilm formation" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1900190 ! regulation of single-species biofilm formation +relationship: negatively_regulates GO:0044010 ! single-species biofilm formation + +[Term] +id: GO:1900192 +name: positive regulation of single-species biofilm formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation." [GOC:di, GOC:TermGenie] +synonym: "activation of single-species biofilm formation" NARROW [GOC:TermGenie] +synonym: "up regulation of single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of single-species biofilm formation" EXACT [GOC:TermGenie] +synonym: "upregulation of single-species biofilm formation" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1900190 ! regulation of single-species biofilm formation +relationship: positively_regulates GO:0044010 ! single-species biofilm formation + +[Term] +id: GO:1900193 +name: regulation of oocyte maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +is_a: GO:1903429 ! regulation of cell maturation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0001556 ! oocyte maturation + +[Term] +id: GO:1900194 +name: negative regulation of oocyte maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +synonym: "down regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of oocyte maturation" NARROW [GOC:TermGenie] +is_a: GO:1900193 ! regulation of oocyte maturation +is_a: GO:1903430 ! negative regulation of cell maturation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0001556 ! oocyte maturation + +[Term] +id: GO:1900195 +name: positive regulation of oocyte maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oocyte maturation." [GOC:kmv, GOC:TermGenie] +synonym: "activation of oocyte maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of oocyte maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of oocyte maturation" EXACT [GOC:TermGenie] +is_a: GO:1900193 ! regulation of oocyte maturation +is_a: GO:1903431 ! positive regulation of cell maturation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0001556 ! oocyte maturation + +[Term] +id: GO:1900196 +name: regulation of penicillin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "regulation of penicillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0033244 ! regulation of penicillin metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0042318 ! penicillin biosynthetic process + +[Term] +id: GO:1900197 +name: negative regulation of penicillin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of penicillin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of penicillin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of penicillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0033245 ! negative regulation of penicillin metabolic process +is_a: GO:1900196 ! regulation of penicillin biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0042318 ! penicillin biosynthetic process + +[Term] +id: GO:1900198 +name: positive regulation of penicillin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of penicillin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of penicillin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "activation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of penicillin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of penicillin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of penicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of penicillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of penicillin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of penicillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0033246 ! positive regulation of penicillin metabolic process +is_a: GO:1900196 ! regulation of penicillin biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0042318 ! penicillin biosynthetic process + +[Term] +id: GO:1900199 +name: positive regulation of protein export from nucleus during meiotic anaphase II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm, during anaphase occurring as part of meiosis II." [GOC:al, GOC:TermGenie, PMID:20970342] +synonym: "positive regulation of protein export from nucleus involved in meiotic anaphase II" BROAD [GOC:pr] +is_a: GO:0046827 ! positive regulation of protein export from nucleus + +[Term] +id: GO:1900200 +name: mesenchymal cell apoptotic process involved in metanephros development +namespace: biological_process +def: "Any mesenchymal cell apoptotic process that is involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "mesenchymal cell apoptosis involved in metanephros development" NARROW [] +is_a: GO:0097152 ! mesenchymal cell apoptotic process +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0001656 ! metanephros development + +[Term] +id: GO:1900201 +name: obsolete regulation of spread of virus in host, cell to cell +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "regulation of spread of virus in host, cell to cell" EXACT [] +synonym: "regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900202 +name: obsolete negative regulation of spread of virus in host, cell to cell +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "down regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "down regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "down regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "down-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "downregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "downregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "downregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "downregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "inhibition of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "inhibition of spread of virus in host, cell to cell" NARROW [GOC:TermGenie] +synonym: "inhibition of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "inhibition of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "negative regulation of spread of virus in host, cell to cell" EXACT [] +synonym: "negative regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900203 +name: obsolete positive regulation of spread of virus in host, cell to cell +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of spread of virus in host, cell to cell." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "activation of spread of virus in host, cell to cell" NARROW [GOC:TermGenie] +synonym: "activation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "activation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "positive regulation of spread of virus in host, cell to cell" EXACT [] +synonym: "positive regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "up regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "up-regulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "upregulation of cell to cell spread of virus within host" EXACT [GOC:TermGenie] +synonym: "upregulation of spread of virus in host, cell to cell" EXACT [GOC:TermGenie] +synonym: "upregulation of spread of virus within host, cell to cell" EXACT [GOC:TermGenie] +synonym: "upregulation of viral spread within host, cell to cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900204 +name: apoptotic process involved in metanephric collecting duct development +namespace: biological_process +def: "Any apoptotic process that is involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0072205 ! metanephric collecting duct development + +[Term] +id: GO:1900205 +name: apoptotic process involved in metanephric nephron tubule development +namespace: biological_process +def: "Any apoptotic process that is involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +is_a: GO:1902742 ! apoptotic process involved in development +relationship: part_of GO:0072234 ! metanephric nephron tubule development + +[Term] +id: GO:1900206 +name: regulation of pronephric nephron tubule development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pronephric nephron tubule development." [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0039020 ! pronephric nephron tubule development + +[Term] +id: GO:1900207 +name: negative regulation of pronephric nephron tubule development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pronephric nephron tubule development." [GOC:bf, GOC:TermGenie, PMID:9758706] +synonym: "down regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of pronephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "inhibition of pronephric nephron tubule development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1900206 ! regulation of pronephric nephron tubule development +relationship: negatively_regulates GO:0039020 ! pronephric nephron tubule development + +[Term] +id: GO:1900208 +name: regulation of cardiolipin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] +synonym: "regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: regulates GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:1900209 +name: negative regulation of cardiolipin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] +synonym: "down regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of cardiolipin metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +is_a: GO:1900208 ! regulation of cardiolipin metabolic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:1900210 +name: positive regulation of cardiolipin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiolipin metabolic process." [GOC:TermGenie] +synonym: "activation of cardiolipin metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "activation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "activation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of cardiolipin metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiolipin metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of diphosphatidylglycerol metabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of diphosphatidylglycerol metabolism" RELATED [GOC:TermGenie] +is_a: GO:1900208 ! regulation of cardiolipin metabolic process +is_a: GO:1903727 ! positive regulation of phospholipid metabolic process +relationship: positively_regulates GO:0032048 ! cardiolipin metabolic process + +[Term] +id: GO:1900211 +name: regulation of mesenchymal cell apoptotic process involved in metanephros development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] +is_a: GO:1904748 ! regulation of apoptotic process involved in development +is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process +relationship: regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development + +[Term] +id: GO:1900212 +name: negative regulation of mesenchymal cell apoptotic process involved in metanephros development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "down regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +synonym: "downregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +synonym: "inhibition of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] +synonym: "negative regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] +is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +is_a: GO:2001054 ! negative regulation of mesenchymal cell apoptotic process +relationship: negatively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development + +[Term] +id: GO:1900213 +name: positive regulation of mesenchymal cell apoptotic process involved in metanephros development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development." [GOC:mtg_apoptosis, GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "activation of mesenchymal cell apoptosis involved in metanephros development" NARROW [GOC:TermGenie] +synonym: "positive regulation of mesenchymal cell apoptosis involved in metanephros development" NARROW [] +synonym: "up regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +synonym: "upregulation of mesenchymal cell apoptosis involved in metanephros development" EXACT [GOC:TermGenie] +is_a: GO:1900211 ! regulation of mesenchymal cell apoptotic process involved in metanephros development +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +is_a: GO:2001055 ! positive regulation of mesenchymal cell apoptotic process +relationship: positively_regulates GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development + +[Term] +id: GO:1900214 +name: regulation of apoptotic process involved in metanephric collecting duct development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development + +[Term] +id: GO:1900215 +name: negative regulation of apoptotic process involved in metanephric collecting duct development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "down regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "down regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "down-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "down-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "downregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "downregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "downregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "inhibition of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "inhibition of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "inhibition of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "negative regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "negative regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "negative regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +relationship: negatively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development + +[Term] +id: GO:1900216 +name: positive regulation of apoptotic process involved in metanephric collecting duct development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric collecting duct development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "activation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "activation of apoptotic process involved in metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "activation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "activation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "activation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "activation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "positive regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "positive regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "positive regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "up regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up-regulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "up-regulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "up-regulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic program of metanephric collecting duct development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic programmed cell death of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "upregulation of programmed cell death by apoptosis of metanephric collecting duct development" EXACT [GOC:TermGenie] +synonym: "upregulation of signaling (initiator) caspase activity of metanephric collecting duct development" RELATED [GOC:TermGenie] +synonym: "upregulation of type I programmed cell death of metanephric collecting duct development" NARROW [GOC:TermGenie] +is_a: GO:1900214 ! regulation of apoptotic process involved in metanephric collecting duct development +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +relationship: positively_regulates GO:1900204 ! apoptotic process involved in metanephric collecting duct development + +[Term] +id: GO:1900217 +name: regulation of apoptotic process involved in metanephric nephron tubule development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development + +[Term] +id: GO:1900218 +name: negative regulation of apoptotic process involved in metanephric nephron tubule development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "down regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "down regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "down-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "down-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "downregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "downregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "inhibition of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "inhibition of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "inhibition of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "negative regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "negative regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "negative regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +relationship: negatively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development + +[Term] +id: GO:1900219 +name: positive regulation of apoptotic process involved in metanephric nephron tubule development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in metanephric nephron tubule development." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:17314325] +synonym: "activation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "activation of apoptotic process involved in metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "activation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "activation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "activation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "activation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "positive regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "positive regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "positive regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "up regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up-regulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "up-regulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "up-regulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic program of metanephric nephron tubule development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic programmed cell death of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "upregulation of programmed cell death by apoptosis of metanephric nephron tubule development" EXACT [GOC:TermGenie] +synonym: "upregulation of signaling (initiator) caspase activity of metanephric nephron tubule development" RELATED [GOC:TermGenie] +synonym: "upregulation of type I programmed cell death of metanephric nephron tubule development" NARROW [GOC:TermGenie] +is_a: GO:1900217 ! regulation of apoptotic process involved in metanephric nephron tubule development +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +relationship: positively_regulates GO:1900205 ! apoptotic process involved in metanephric nephron tubule development + +[Term] +id: GO:1900220 +name: semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis +namespace: biological_process +def: "Any semaphorin-plexin signaling pathway that contributes to bone trabecula morphogenesis." [GOC:BHF, GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway of bone trabecula morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0071526 ! semaphorin-plexin signaling pathway +relationship: part_of GO:0061430 ! bone trabecula morphogenesis + +[Term] +id: GO:1900221 +name: regulation of amyloid-beta clearance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of beta-amyloid clearance" EXACT [] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0097242 ! amyloid-beta clearance + +[Term] +id: GO:1900222 +name: negative regulation of amyloid-beta clearance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +synonym: "inhibition of beta-amyloid clearance" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-amyloid clearance" EXACT [] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1900221 ! regulation of amyloid-beta clearance +relationship: negatively_regulates GO:0097242 ! amyloid-beta clearance + +[Term] +id: GO:1900223 +name: positive regulation of amyloid-beta clearance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance." [GOC:BHF, GOC:TermGenie] +synonym: "activation of beta-amyloid clearance" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-amyloid clearance" EXACT [] +synonym: "up regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-amyloid clearance" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1900221 ! regulation of amyloid-beta clearance +relationship: positively_regulates GO:0097242 ! amyloid-beta clearance + +[Term] +id: GO:1900224 +name: positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GOC:BHF, GOC:TermGenie] +synonym: "activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] +synonym: "up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +synonym: "upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm" EXACT [GOC:TermGenie] +is_a: GO:0032927 ! positive regulation of activin receptor signaling pathway +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1900175 ! regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry +relationship: positively_regulates GO:1900164 ! nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1900225 +name: regulation of NLRP3 inflammasome complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] +synonym: "regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0044546 ! NLRP3 inflammasome complex assembly + +[Term] +id: GO:1900226 +name: negative regulation of NLRP3 inflammasome complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] +synonym: "down regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "down regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "down-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "downregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "inhibition of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly +relationship: negatively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly + +[Term] +id: GO:1900227 +name: positive regulation of NLRP3 inflammasome complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NLRP3 inflammasome complex assembly." [GOC:TermGenie] +synonym: "activation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "activation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "activation of NLRP3 inflammasome complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "up regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "up regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "up-regulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of NALP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of NLRP3 inflammasome activation" RELATED [GOC:TermGenie] +synonym: "upregulation of NLRP3 inflammasome complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1900225 ! regulation of NLRP3 inflammasome complex assembly +relationship: positively_regulates GO:0044546 ! NLRP3 inflammasome complex assembly + +[Term] +id: GO:1900228 +name: regulation of single-species biofilm formation in or on host organism +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:1900190 ! regulation of single-species biofilm formation +relationship: regulates GO:0044407 ! single-species biofilm formation in or on host organism + +[Term] +id: GO:1900229 +name: negative regulation of single-species biofilm formation in or on host organism +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] +synonym: "down regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +synonym: "down-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +synonym: "downregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +synonym: "inhibition of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie] +is_a: GO:1900191 ! negative regulation of single-species biofilm formation +is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism +relationship: negatively_regulates GO:0044407 ! single-species biofilm formation in or on host organism + +[Term] +id: GO:1900230 +name: positive regulation of single-species biofilm formation in or on host organism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation in or on host organism." [GOC:di, GOC:TermGenie] +synonym: "activation of single-species biofilm formation in or on host organism" NARROW [GOC:TermGenie] +synonym: "up regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +synonym: "up-regulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +synonym: "upregulation of single-species biofilm formation in or on host organism" EXACT [GOC:TermGenie] +is_a: GO:1900192 ! positive regulation of single-species biofilm formation +is_a: GO:1900228 ! regulation of single-species biofilm formation in or on host organism +relationship: positively_regulates GO:0044407 ! single-species biofilm formation in or on host organism + +[Term] +id: GO:1900231 +name: regulation of single-species biofilm formation on inanimate substrate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] +is_a: GO:1900190 ! regulation of single-species biofilm formation +relationship: regulates GO:0044011 ! single-species biofilm formation on inanimate substrate + +[Term] +id: GO:1900232 +name: negative regulation of single-species biofilm formation on inanimate substrate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] +synonym: "down regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +synonym: "down-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +synonym: "downregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +synonym: "inhibition of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] +is_a: GO:1900191 ! negative regulation of single-species biofilm formation +is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate +relationship: negatively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate + +[Term] +id: GO:1900233 +name: positive regulation of single-species biofilm formation on inanimate substrate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of single-species biofilm formation on inanimate substrate." [GOC:di, GOC:TermGenie] +synonym: "activation of single-species biofilm formation on inanimate substrate" NARROW [GOC:TermGenie] +synonym: "up regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +synonym: "up-regulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +synonym: "upregulation of single-species biofilm formation on inanimate substrate" EXACT [GOC:TermGenie] +is_a: GO:1900192 ! positive regulation of single-species biofilm formation +is_a: GO:1900231 ! regulation of single-species biofilm formation on inanimate substrate +relationship: positively_regulates GO:0044011 ! single-species biofilm formation on inanimate substrate + +[Term] +id: GO:1900234 +name: regulation of Kit signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] +synonym: "regulation of Kit signalling pathway" EXACT [GOC:mah] +synonym: "regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0038109 ! Kit signaling pathway + +[Term] +id: GO:1900235 +name: negative regulation of Kit signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] +synonym: "down regulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of Kit signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of Kit signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1900234 ! regulation of Kit signaling pathway +relationship: negatively_regulates GO:0038109 ! Kit signaling pathway + +[Term] +id: GO:1900236 +name: positive regulation of Kit signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Kit signaling pathway." [GOC:signaling, GOC:TermGenie] +synonym: "activation of Kit signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "activation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of Kit signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Kit signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of stem cell factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of stem cell factor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1900234 ! regulation of Kit signaling pathway +relationship: positively_regulates GO:0038109 ! Kit signaling pathway + +[Term] +id: GO:1900237 +name: positive regulation of induction of conjugation with cellular fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion." [GOC:TermGenie] +synonym: "up regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of induction of conjugation with cellular fusion" EXACT [GOC:TermGenie] +is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion +relationship: positively_regulates GO:0010514 ! induction of conjugation with cellular fusion + +[Term] +id: GO:1900238 +name: regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of regulation of metanephric mesenchymal cell migration, by platelet-derived growth factor receptor-beta signaling pathway." [GOC:mtg_kidney_jan10, GOC:TermGenie, GOC:yaf, PMID:19019919] +synonym: "regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +synonym: "regulation of metanephric mesenchyme chemotaxis by platelet-derived growth factor receptor-beta signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway +is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration + +[Term] +id: GO:1900239 +name: regulation of phenotypic switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] +synonym: "regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0036166 ! phenotypic switching + +[Term] +id: GO:1900240 +name: negative regulation of phenotypic switching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] +synonym: "down regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down regulation of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down-regulation of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "downregulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "downregulation of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "inhibition of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "inhibition of phenotypic switching" NARROW [GOC:TermGenie] +synonym: "negative regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1900239 ! regulation of phenotypic switching +relationship: negatively_regulates GO:0036166 ! phenotypic switching + +[Term] +id: GO:1900241 +name: positive regulation of phenotypic switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phenotypic switching." [GOC:di, GOC:TermGenie] +synonym: "activation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "activation of phenotypic switching" NARROW [GOC:TermGenie] +synonym: "positive regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up regulation of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up-regulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up-regulation of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "upregulation of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "upregulation of phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1900239 ! regulation of phenotypic switching +relationship: positively_regulates GO:0036166 ! phenotypic switching + +[Term] +id: GO:1900242 +name: regulation of synaptic vesicle endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] +subset: goslim_synapse +synonym: "regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:1903421 ! regulation of synaptic vesicle recycling +relationship: regulates GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:1900243 +name: negative regulation of synaptic vesicle endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle endocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis +is_a: GO:1903422 ! negative regulation of synaptic vesicle recycling +relationship: negatively_regulates GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:1900244 +name: positive regulation of synaptic vesicle endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis." [GOC:BHF, GOC:TermGenie] +synonym: "activation of synaptic vesicle endocytosis" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle endocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle retrieval" RELATED [GOC:TermGenie] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:1900242 ! regulation of synaptic vesicle endocytosis +is_a: GO:1903423 ! positive regulation of synaptic vesicle recycling +relationship: positively_regulates GO:0048488 ! synaptic vesicle endocytosis + +[Term] +id: GO:1900245 +name: positive regulation of MDA-5 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway." [GOC:TermGenie] +synonym: "activation of IFIH1 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of MDA-5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of MDA5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of melanoma differentiation-associated gene 5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of MDA-5 signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of IFIH1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of MDA-5 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of MDA5 signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of melanoma differentiation-associated gene 5 signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0039533 ! regulation of MDA-5 signaling pathway +is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0039530 ! MDA-5 signaling pathway + +[Term] +id: GO:1900246 +name: positive regulation of RIG-I signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway." [GOC:TermGenie] +synonym: "activation of DDX58 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of retinoic acid inducible gene I signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of RIG-I signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of RIG-I signalling pathway" EXACT [GOC:mah] +synonym: "up regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of DDX58 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of retinoic acid inducible gene I signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of RIG-I signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0039535 ! regulation of RIG-I signaling pathway +is_a: GO:0062208 ! positive regulation of pattern recognition receptor signaling pathway +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0039529 ! RIG-I signaling pathway + +[Term] +id: GO:1900247 +name: regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +is_a: GO:0006448 ! regulation of translational elongation +relationship: regulates GO:0002182 ! cytoplasmic translational elongation + +[Term] +id: GO:1900248 +name: negative regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie] +is_a: GO:0045900 ! negative regulation of translational elongation +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation +is_a: GO:2000766 ! negative regulation of cytoplasmic translation +relationship: negatively_regulates GO:0002182 ! cytoplasmic translational elongation + +[Term] +id: GO:1900249 +name: positive regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +is_a: GO:0045901 ! positive regulation of translational elongation +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation +relationship: positively_regulates GO:0002182 ! cytoplasmic translational elongation + +[Term] +id: GO:1900256 +name: regulation of beta1-adrenergic receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] +synonym: "regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:1900257 +name: negative regulation of beta1-adrenergic receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] +synonym: "down regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "down regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "downregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +synonym: "inhibition of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "inhibition of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:1900258 +name: positive regulation of beta1-adrenergic receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of beta1-adrenergic receptor activity." [GOC:TermGenie] +synonym: "activation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "activation of beta1-adrenergic receptor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "up regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "up regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta1 adrenoceptor" EXACT [GOC:TermGenie] +synonym: "upregulation of beta1-adrenergic receptor activity" EXACT [GOC:TermGenie] +is_a: GO:1900256 ! regulation of beta1-adrenergic receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1900259 +name: regulation of RNA-directed 5'-3' RNA polymerase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] +synonym: "regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA-directed RNA polymerase activity" BROAD [] +synonym: "regulation of transcriptase" BROAD [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity +is_a: GO:1903506 ! regulation of nucleic acid-templated transcription + +[Term] +id: GO:1900260 +name: negative regulation of RNA-directed 5'-3' RNA polymerase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] +synonym: "down regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "down regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "down regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "down regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "down regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "down regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "down regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "down-regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "down-regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "down-regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "down-regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "down-regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "down-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "down-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "downregulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "downregulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "downregulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "downregulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "downregulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "downregulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RDRP" RELATED [GOC:TermGenie] +synonym: "downregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "inhibition of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "inhibition of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "inhibition of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "inhibition of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "inhibition of polymerase L" RELATED [GOC:TermGenie] +synonym: "inhibition of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RDRP" RELATED [GOC:TermGenie] +synonym: "inhibition of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of transcriptase" BROAD [GOC:TermGenie] +synonym: "negative regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "negative regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "negative regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "negative regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "negative regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "negative regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "negative regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA-directed RNA polymerase activity" BROAD [] +synonym: "negative regulation of transcriptase" BROAD [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1900259 ! regulation of RNA-directed 5'-3' RNA polymerase activity +is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription + +[Term] +id: GO:1900261 +name: positive regulation of RNA-directed 5'-3' RNA polymerase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity." [GOC:pf, GOC:TermGenie] +synonym: "activation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "activation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "activation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "activation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "activation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "activation of polymerase L" RELATED [GOC:TermGenie] +synonym: "activation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of RDRP" RELATED [GOC:TermGenie] +synonym: "activation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "activation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "activation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "activation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "activation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "activation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "activation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "activation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of RNA-directed RNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of transcriptase" BROAD [GOC:TermGenie] +synonym: "positive regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "positive regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "positive regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "positive regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "positive regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "positive regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "positive regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA-directed RNA polymerase activity" BROAD [] +synonym: "positive regulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "up regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "up regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "up regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "up regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "up regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "up regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "up regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "up-regulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "up-regulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "up-regulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "up-regulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "up-regulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "up-regulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RDRP" RELATED [GOC:TermGenie] +synonym: "up-regulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcriptase" BROAD [GOC:TermGenie] +synonym: "upregulation of 3D polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [GOC:TermGenie] +synonym: "upregulation of PB1 proteins" RELATED [GOC:TermGenie] +synonym: "upregulation of PB2 proteins" RELATED [GOC:TermGenie] +synonym: "upregulation of phage f2 replicase" NARROW [GOC:TermGenie] +synonym: "upregulation of polymerase L" RELATED [GOC:TermGenie] +synonym: "upregulation of Q-beta replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RDRP" RELATED [GOC:TermGenie] +synonym: "upregulation of ribonucleic acid replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ribonucleic replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ribonucleic synthetase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of RNA nucleotidyltransferase (RNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA synthetase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA-dependent RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA-dependent RNA replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA-directed RNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of transcriptase" BROAD [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1900259 ! regulation of RNA-directed 5'-3' RNA polymerase activity + +[Term] +id: GO:1900262 +name: regulation of DNA-directed DNA polymerase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] +synonym: "regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +is_a: GO:2000278 ! regulation of DNA biosynthetic process + +[Term] +id: GO:1900263 +name: negative regulation of DNA-directed DNA polymerase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] +synonym: "down regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "down regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "down regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "down regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "down regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "down regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "down regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "down-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "down-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "down-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "down-regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "down-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "down-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of duplicase" BROAD [GOC:TermGenie] +synonym: "downregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "downregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of sequenase" RELATED [GOC:TermGenie] +synonym: "downregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "downregulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "downregulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "downregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "inhibition of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of duplicase" BROAD [GOC:TermGenie] +synonym: "inhibition of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "inhibition of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sequenase" RELATED [GOC:TermGenie] +synonym: "inhibition of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "inhibition of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "inhibition of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "inhibition of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "negative regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "negative regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "negative regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "negative regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "negative regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "negative regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process + +[Term] +id: GO:1900264 +name: positive regulation of DNA-directed DNA polymerase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] +synonym: "activation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "activation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "activation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "activation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "activation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "activation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "activation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "activation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "activation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "activation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "activation of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of duplicase" BROAD [GOC:TermGenie] +synonym: "activation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "activation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of sequenase" RELATED [GOC:TermGenie] +synonym: "activation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "activation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "activation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "activation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "positive regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "positive regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "positive regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "positive regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "positive regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "positive regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "up regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "up regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "up regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "up regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "up regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "up regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of duplicase" BROAD [GOC:TermGenie] +synonym: "up-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "up-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of sequenase" RELATED [GOC:TermGenie] +synonym: "up-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "up-regulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "up-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "up-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA duplicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA polymerase alpha" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase beta" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase gamma" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase I" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase II" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase III" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA polymerase V activity" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA replicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of duplicase" BROAD [GOC:TermGenie] +synonym: "upregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of Klenow fragment" NARROW [GOC:TermGenie] +synonym: "upregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of sequenase" RELATED [GOC:TermGenie] +synonym: "upregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of Taq DNA polymerase" NARROW [GOC:TermGenie] +synonym: "upregulation of Taq Pol I" NARROW [GOC:TermGenie] +synonym: "upregulation of Tca DNA polymerase" NARROW [GOC:TermGenie] +synonym: "upregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process + +[Term] +id: GO:1900265 +name: regulation of substance P receptor binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] +synonym: "regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1900266 +name: negative regulation of substance P receptor binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] +synonym: "down regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "down regulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "down regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "down-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "downregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "inhibition of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "inhibition of substance P receptor binding" NARROW [GOC:TermGenie] +synonym: "inhibition of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "negative regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +is_a: GO:1900121 ! negative regulation of receptor binding +is_a: GO:1900265 ! regulation of substance P receptor binding + +[Term] +id: GO:1900267 +name: positive regulation of substance P receptor binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of substance P receptor binding." [GOC:TermGenie] +synonym: "activation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "activation of substance P receptor binding" NARROW [GOC:TermGenie] +synonym: "activation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "positive regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "up regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "up regulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "up regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "up-regulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of substance P receptor ligand" NARROW [GOC:TermGenie] +synonym: "upregulation of neurokinin-1 receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of substance P receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of substance P receptor ligand" NARROW [GOC:TermGenie] +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:1900265 ! regulation of substance P receptor binding + +[Term] +id: GO:1900268 +name: regulation of reverse transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reverse transcription." [GOC:TermGenie] +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: regulates GO:0001171 ! reverse transcription + +[Term] +id: GO:1900269 +name: negative regulation of reverse transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse transcription." [GOC:TermGenie] +synonym: "down regulation of reverse transcription" EXACT [GOC:TermGenie] +synonym: "down-regulation of reverse transcription" EXACT [GOC:TermGenie] +synonym: "downregulation of reverse transcription" EXACT [GOC:TermGenie] +synonym: "inhibition of reverse transcription" NARROW [GOC:TermGenie] +is_a: GO:1900268 ! regulation of reverse transcription +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process +relationship: negatively_regulates GO:0001171 ! reverse transcription + +[Term] +id: GO:1900270 +name: positive regulation of reverse transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of reverse transcription." [GOC:TermGenie] +synonym: "activation of reverse transcription" NARROW [GOC:TermGenie] +synonym: "up regulation of reverse transcription" EXACT [GOC:TermGenie] +synonym: "up-regulation of reverse transcription" EXACT [GOC:TermGenie] +synonym: "upregulation of reverse transcription" EXACT [GOC:TermGenie] +is_a: GO:1900268 ! regulation of reverse transcription +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process +relationship: positively_regulates GO:0001171 ! reverse transcription + +[Term] +id: GO:1900271 +name: regulation of long-term synaptic potentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "regulation of LTP" RELATED [GOC:TermGenie] +is_a: GO:0048167 ! regulation of synaptic plasticity +relationship: regulates GO:0060291 ! long-term synaptic potentiation + +[Term] +id: GO:1900272 +name: negative regulation of long-term synaptic potentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "down regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of LTP" RELATED [GOC:TermGenie] +synonym: "down-regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "down-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of LTP" RELATED [GOC:TermGenie] +synonym: "downregulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "downregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of LTP" RELATED [GOC:TermGenie] +synonym: "inhibition of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "inhibition of long-term synaptic potentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of LTP" RELATED [GOC:TermGenie] +synonym: "negative regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "negative regulation of LTP" RELATED [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1900271 ! regulation of long-term synaptic potentiation +relationship: negatively_regulates GO:0060291 ! long-term synaptic potentiation + +[Term] +id: GO:1900273 +name: positive regulation of long-term synaptic potentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "activation of long-term synaptic potentiation" NARROW [GOC:TermGenie] +synonym: "activation of LTP" RELATED [GOC:TermGenie] +synonym: "positive regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "positive regulation of LTP" RELATED [GOC:TermGenie] +synonym: "up regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "up regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of LTP" RELATED [GOC:TermGenie] +synonym: "up-regulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "up-regulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of LTP" RELATED [GOC:TermGenie] +synonym: "upregulation of long-term potentiation" BROAD [GOC:TermGenie] +synonym: "upregulation of long-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of LTP" RELATED [GOC:TermGenie] +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:1900271 ! regulation of long-term synaptic potentiation +relationship: positively_regulates GO:0060291 ! long-term synaptic potentiation + +[Term] +id: GO:1900274 +name: regulation of phospholipase C activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "regulation of phosphatidase C" RELATED [GOC:TermGenie] +is_a: GO:0010517 ! regulation of phospholipase activity + +[Term] +id: GO:1900275 +name: negative regulation of phospholipase C activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "down regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "down regulation of phosphatidase C" RELATED [GOC:TermGenie] +synonym: "down regulation of phospholipase C activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "down-regulation of phosphatidase C" RELATED [GOC:TermGenie] +synonym: "down-regulation of phospholipase C activity" EXACT [GOC:TermGenie] +synonym: "downregulation of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "downregulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "downregulation of phosphatidase C" RELATED [GOC:TermGenie] +synonym: "downregulation of phospholipase C activity" EXACT [GOC:TermGenie] +synonym: "inhibition of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "inhibition of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "inhibition of phosphatidase C" RELATED [GOC:TermGenie] +synonym: "inhibition of phospholipase C activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of lecithinase C activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of lipophosphodiesterase C" RELATED [GOC:TermGenie] +synonym: "negative regulation of phosphatidase C" RELATED [GOC:TermGenie] +is_a: GO:0010519 ! negative regulation of phospholipase activity +is_a: GO:1900274 ! regulation of phospholipase C activity + +[Term] +id: GO:1900276 +name: regulation of proteinase activated receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:1900277 +name: negative regulation of proteinase activated receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +synonym: "inhibition of proteinase activated receptor activity" NARROW [GOC:TermGenie] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:1900276 ! regulation of proteinase activated receptor activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:1900278 +name: positive regulation of proteinase activated receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proteinase activated receptor activity." [GOC:BHF, GOC:TermGenie] +synonym: "activation of proteinase activated receptor activity" NARROW [GOC:TermGenie] +synonym: "up regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of proteinase activated receptor activity" EXACT [GOC:TermGenie] +is_a: GO:1900276 ! regulation of proteinase activated receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1900279 +name: regulation of CD4-positive, alpha-beta T cell costimulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] +synonym: "regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000523 ! regulation of T cell costimulation +relationship: regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation + +[Term] +id: GO:1900280 +name: negative regulation of CD4-positive, alpha-beta T cell costimulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] +synonym: "down regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +synonym: "downregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +synonym: "inhibition of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie] +synonym: "negative regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] +is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation +is_a: GO:2000524 ! negative regulation of T cell costimulation +relationship: negatively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation + +[Term] +id: GO:1900281 +name: positive regulation of CD4-positive, alpha-beta T cell costimulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell costimulation." [GOC:BHF, GOC:pr, GOC:TermGenie] +synonym: "activation of CD4-positive, alpha beta T cell costimulation" NARROW [GOC:TermGenie] +synonym: "positive regulation of CD4-positive, alpha beta T cell costimulation" EXACT [] +synonym: "up regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +synonym: "upregulation of CD4-positive, alpha beta T cell costimulation" EXACT [GOC:TermGenie] +is_a: GO:1900279 ! regulation of CD4-positive, alpha-beta T cell costimulation +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000525 ! positive regulation of T cell costimulation +relationship: positively_regulates GO:0035783 ! CD4-positive, alpha-beta T cell costimulation + +[Term] +id: GO:1900282 +name: regulation of cellobiose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:2000930 ! regulation of cellobiose metabolic process +relationship: regulates GO:2000892 ! cellobiose catabolic process + +[Term] +id: GO:1900283 +name: negative regulation of cellobiose catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of cellobiose catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cellobiose catabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:1900282 ! regulation of cellobiose catabolic process +is_a: GO:2000931 ! negative regulation of cellobiose metabolic process +relationship: negatively_regulates GO:2000892 ! cellobiose catabolic process + +[Term] +id: GO:1900284 +name: positive regulation of cellobiose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellobiose catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of cellobiose catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of cellobiose catabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellobiose catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of cellobiose catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cellobiose catabolism" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1900282 ! regulation of cellobiose catabolic process +is_a: GO:2000932 ! positive regulation of cellobiose metabolic process +relationship: positively_regulates GO:2000892 ! cellobiose catabolic process + +[Term] +id: GO:1900285 +name: regulation of cellotriose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001096 ! cellotriose transport + +[Term] +id: GO:1900286 +name: negative regulation of cellotriose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of cellotriose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellotriose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of cellotriose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of cellotriose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900285 ! regulation of cellotriose transport +relationship: negatively_regulates GO:2001096 ! cellotriose transport + +[Term] +id: GO:1900287 +name: positive regulation of cellotriose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of cellotriose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of cellotriose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellotriose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of cellotriose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900285 ! regulation of cellotriose transport +relationship: positively_regulates GO:2001096 ! cellotriose transport + +[Term] +id: GO:1900288 +name: regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process + +[Term] +id: GO:1900289 +name: negative regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process +relationship: negatively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process + +[Term] +id: GO:1900290 +name: positive regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme F420-dependent nitroimidazole breakdown" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme F420-dependent nitroimidazole catabolism" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme F420-dependent nitroimidazole reduction" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "positive regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme F420-dependent nitroimidazole breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme F420-dependent nitroimidazole catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme F420-dependent nitroimidazole reduction" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme F420-dependent nitroreductase activity" RELATED [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900288 ! regulation of coenzyme F420-dependent bicyclic nitroimidazole catabolic process +relationship: positively_regulates GO:0052799 ! coenzyme F420-dependent bicyclic nitroimidazole catabolic process + +[Term] +id: GO:1900291 +name: regulation of galactotriose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001093 ! galactotriose transport + +[Term] +id: GO:1900292 +name: negative regulation of galactotriose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of galactotriose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of galactotriose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of galactotriose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of galactotriose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900291 ! regulation of galactotriose transport +relationship: negatively_regulates GO:2001093 ! galactotriose transport + +[Term] +id: GO:1900293 +name: positive regulation of galactotriose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of galactotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of galactotriose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of galactotriose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of galactotriose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of galactotriose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900291 ! regulation of galactotriose transport +relationship: positively_regulates GO:2001093 ! galactotriose transport + +[Term] +id: GO:1900294 +name: regulation of heptasaccharide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001104 ! heptasaccharide transport + +[Term] +id: GO:1900295 +name: negative regulation of heptasaccharide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of heptasaccharide transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of heptasaccharide transport" EXACT [GOC:TermGenie] +synonym: "downregulation of heptasaccharide transport" EXACT [GOC:TermGenie] +synonym: "inhibition of heptasaccharide transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900294 ! regulation of heptasaccharide transport +relationship: negatively_regulates GO:2001104 ! heptasaccharide transport + +[Term] +id: GO:1900296 +name: positive regulation of heptasaccharide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heptasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of heptasaccharide transport" NARROW [GOC:TermGenie] +synonym: "up regulation of heptasaccharide transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of heptasaccharide transport" EXACT [GOC:TermGenie] +synonym: "upregulation of heptasaccharide transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900294 ! regulation of heptasaccharide transport +relationship: positively_regulates GO:2001104 ! heptasaccharide transport + +[Term] +id: GO:1900297 +name: regulation of hexasaccharide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001102 ! hexasaccharide transport + +[Term] +id: GO:1900298 +name: negative regulation of hexasaccharide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of hexasaccharide transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexasaccharide transport" EXACT [GOC:TermGenie] +synonym: "downregulation of hexasaccharide transport" EXACT [GOC:TermGenie] +synonym: "inhibition of hexasaccharide transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900297 ! regulation of hexasaccharide transport +relationship: negatively_regulates GO:2001102 ! hexasaccharide transport + +[Term] +id: GO:1900299 +name: positive regulation of hexasaccharide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hexasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of hexasaccharide transport" NARROW [GOC:TermGenie] +synonym: "up regulation of hexasaccharide transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexasaccharide transport" EXACT [GOC:TermGenie] +synonym: "upregulation of hexasaccharide transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900297 ! regulation of hexasaccharide transport +relationship: positively_regulates GO:2001102 ! hexasaccharide transport + +[Term] +id: GO:1900300 +name: regulation of laminarabiose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001086 ! laminarabiose transport + +[Term] +id: GO:1900301 +name: negative regulation of laminarabiose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of laminarabiose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of laminarabiose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of laminarabiose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of laminarabiose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900300 ! regulation of laminarabiose transport +relationship: negatively_regulates GO:2001086 ! laminarabiose transport + +[Term] +id: GO:1900302 +name: positive regulation of laminarabiose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of laminarabiose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of laminarabiose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of laminarabiose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of laminarabiose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of laminarabiose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900300 ! regulation of laminarabiose transport +relationship: positively_regulates GO:2001086 ! laminarabiose transport + +[Term] +id: GO:1900303 +name: regulation of laminaritriose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001097 ! laminaritriose transport + +[Term] +id: GO:1900304 +name: negative regulation of laminaritriose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of laminaritriose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of laminaritriose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of laminaritriose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of laminaritriose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900303 ! regulation of laminaritriose transport +relationship: negatively_regulates GO:2001097 ! laminaritriose transport + +[Term] +id: GO:1900305 +name: positive regulation of laminaritriose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of laminaritriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of laminaritriose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of laminaritriose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of laminaritriose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of laminaritriose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900303 ! regulation of laminaritriose transport +relationship: positively_regulates GO:2001097 ! laminaritriose transport + +[Term] +id: GO:1900306 +name: regulation of maltoheptaose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1900294 ! regulation of heptasaccharide transport +relationship: regulates GO:2001105 ! maltoheptaose transport + +[Term] +id: GO:1900307 +name: negative regulation of maltoheptaose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltoheptaose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltoheptaose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltoheptaose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltoheptaose transport" NARROW [GOC:TermGenie] +is_a: GO:1900295 ! negative regulation of heptasaccharide transport +is_a: GO:1900306 ! regulation of maltoheptaose transport +relationship: negatively_regulates GO:2001105 ! maltoheptaose transport + +[Term] +id: GO:1900308 +name: positive regulation of maltoheptaose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltoheptaose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltoheptaose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltoheptaose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltoheptaose transport" EXACT [GOC:TermGenie] +is_a: GO:1900296 ! positive regulation of heptasaccharide transport +is_a: GO:1900306 ! regulation of maltoheptaose transport +relationship: positively_regulates GO:2001105 ! maltoheptaose transport + +[Term] +id: GO:1900309 +name: regulation of maltoheptaose metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +relationship: regulates GO:2001122 ! maltoheptaose metabolic process + +[Term] +id: GO:1900310 +name: negative regulation of maltoheptaose metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of maltoheptaose metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of maltoheptaose metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:1900309 ! regulation of maltoheptaose metabolic process +relationship: negatively_regulates GO:2001122 ! maltoheptaose metabolic process + +[Term] +id: GO:1900311 +name: positive regulation of maltoheptaose metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltoheptaose metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltoheptaose metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of maltoheptaose metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of maltoheptaose metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of maltoheptaose metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:1900309 ! regulation of maltoheptaose metabolic process +relationship: positively_regulates GO:2001122 ! maltoheptaose metabolic process + +[Term] +id: GO:1900312 +name: regulation of maltohexaose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1900297 ! regulation of hexasaccharide transport +relationship: regulates GO:2001103 ! maltohexaose transport + +[Term] +id: GO:1900313 +name: negative regulation of maltohexaose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltohexaose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltohexaose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltohexaose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltohexaose transport" NARROW [GOC:TermGenie] +is_a: GO:1900298 ! negative regulation of hexasaccharide transport +is_a: GO:1900312 ! regulation of maltohexaose transport +relationship: negatively_regulates GO:2001103 ! maltohexaose transport + +[Term] +id: GO:1900314 +name: positive regulation of maltohexaose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltohexaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltohexaose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltohexaose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltohexaose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltohexaose transport" EXACT [GOC:TermGenie] +is_a: GO:1900299 ! positive regulation of hexasaccharide transport +is_a: GO:1900312 ! regulation of maltohexaose transport +relationship: positively_regulates GO:2001103 ! maltohexaose transport + +[Term] +id: GO:1900315 +name: regulation of maltopentaose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1900360 ! regulation of pentasaccharide transport +relationship: regulates GO:2001101 ! maltopentaose transport + +[Term] +id: GO:1900316 +name: negative regulation of maltopentaose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltopentaose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltopentaose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltopentaose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltopentaose transport" NARROW [GOC:TermGenie] +is_a: GO:1900315 ! regulation of maltopentaose transport +is_a: GO:1900361 ! negative regulation of pentasaccharide transport +relationship: negatively_regulates GO:2001101 ! maltopentaose transport + +[Term] +id: GO:1900317 +name: positive regulation of maltopentaose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltopentaose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltopentaose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltopentaose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltopentaose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltopentaose transport" EXACT [GOC:TermGenie] +is_a: GO:1900315 ! regulation of maltopentaose transport +is_a: GO:1900362 ! positive regulation of pentasaccharide transport +relationship: positively_regulates GO:2001101 ! maltopentaose transport + +[Term] +id: GO:1900318 +name: regulation of methane biosynthetic process from dimethylamine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001129 ! methane biosynthetic process from dimethylamine + +[Term] +id: GO:1900319 +name: negative regulation of methane biosynthetic process from dimethylamine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine + +[Term] +id: GO:1900320 +name: positive regulation of methane biosynthetic process from dimethylamine +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from dimethylamine" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from dimethylamine" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900318 ! regulation of methane biosynthetic process from dimethylamine +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001129 ! methane biosynthetic process from dimethylamine + +[Term] +id: GO:1900321 +name: regulation of maltotetraose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001099 ! maltotetraose transport + +[Term] +id: GO:1900322 +name: negative regulation of maltotetraose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltotetraose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltotetraose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltotetraose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltotetraose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900321 ! regulation of maltotetraose transport +relationship: negatively_regulates GO:2001099 ! maltotetraose transport + +[Term] +id: GO:1900323 +name: positive regulation of maltotetraose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltotetraose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltotetraose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltotetraose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltotetraose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltotetraose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900321 ! regulation of maltotetraose transport +relationship: positively_regulates GO:2001099 ! maltotetraose transport + +[Term] +id: GO:1900324 +name: regulation of maltotriulose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001090 ! maltotriulose transport + +[Term] +id: GO:1900325 +name: negative regulation of maltotriulose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of maltotriulose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltotriulose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltotriulose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltotriulose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900324 ! regulation of maltotriulose transport +relationship: negatively_regulates GO:2001090 ! maltotriulose transport + +[Term] +id: GO:1900326 +name: positive regulation of maltotriulose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltotriulose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of maltotriulose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltotriulose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltotriulose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltotriulose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900324 ! regulation of maltotriulose transport +relationship: positively_regulates GO:2001090 ! maltotriulose transport + +[Term] +id: GO:1900327 +name: regulation of mannotriose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001095 ! mannotriose transport + +[Term] +id: GO:1900328 +name: negative regulation of mannotriose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of mannotriose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of mannotriose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of mannotriose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of mannotriose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900327 ! regulation of mannotriose transport +relationship: negatively_regulates GO:2001095 ! mannotriose transport + +[Term] +id: GO:1900329 +name: positive regulation of mannotriose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mannotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of mannotriose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of mannotriose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of mannotriose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of mannotriose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900327 ! regulation of mannotriose transport +relationship: positively_regulates GO:2001095 ! mannotriose transport + +[Term] +id: GO:1900330 +name: regulation of methane biosynthetic process from trimethylamine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001130 ! methane biosynthetic process from trimethylamine + +[Term] +id: GO:1900331 +name: negative regulation of methane biosynthetic process from trimethylamine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine + +[Term] +id: GO:1900332 +name: positive regulation of methane biosynthetic process from trimethylamine +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from trimethylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from trimethylamine" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from trimethylamine" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900330 ! regulation of methane biosynthetic process from trimethylamine +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001130 ! methane biosynthetic process from trimethylamine + +[Term] +id: GO:1900333 +name: regulation of methane biosynthetic process from 3-(methylthio)propionic acid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid + +[Term] +id: GO:1900334 +name: negative regulation of methane biosynthetic process from 3-(methylthio)propionic acid +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie] +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid + +[Term] +id: GO:1900335 +name: positive regulation of methane biosynthetic process from 3-(methylthio)propionic acid +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from 3-(methylthio)propionic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from 3-(methylthio)propionic acid" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from 3-(methylthio)propionic acid" EXACT [GOC:TermGenie] +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900333 ! regulation of methane biosynthetic process from 3-(methylthio)propionic acid +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001132 ! methane biosynthetic process from 3-(methylthio)propionic acid + +[Term] +id: GO:1900336 +name: regulation of methane biosynthetic process from carbon monoxide +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001134 ! methane biosynthetic process from carbon monoxide + +[Term] +id: GO:1900337 +name: negative regulation of methane biosynthetic process from carbon monoxide +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie] +is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide + +[Term] +id: GO:1900338 +name: positive regulation of methane biosynthetic process from carbon monoxide +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from carbon monoxide." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from carbon monoxide" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from carbon monoxide" EXACT [GOC:TermGenie] +is_a: GO:1900336 ! regulation of methane biosynthetic process from carbon monoxide +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001134 ! methane biosynthetic process from carbon monoxide + +[Term] +id: GO:1900339 +name: regulation of methane biosynthetic process from formic acid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001127 ! methane biosynthetic process from formic acid + +[Term] +id: GO:1900340 +name: negative regulation of methane biosynthetic process from formic acid +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie] +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001127 ! methane biosynthetic process from formic acid + +[Term] +id: GO:1900341 +name: positive regulation of methane biosynthetic process from formic acid +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from formic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from formic acid" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from formic acid" EXACT [GOC:TermGenie] +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900339 ! regulation of methane biosynthetic process from formic acid +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001127 ! methane biosynthetic process from formic acid + +[Term] +id: GO:1900342 +name: regulation of methane biosynthetic process from dimethyl sulfide +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide + +[Term] +id: GO:1900343 +name: negative regulation of methane biosynthetic process from dimethyl sulfide +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie] +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide + +[Term] +id: GO:1900344 +name: positive regulation of methane biosynthetic process from dimethyl sulfide +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from dimethyl sulfide" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from dimethyl sulfide" EXACT [GOC:TermGenie] +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900342 ! regulation of methane biosynthetic process from dimethyl sulfide +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001131 ! methane biosynthetic process from dimethyl sulfide + +[Term] +id: GO:1900345 +name: regulation of methane biosynthetic process from methanethiol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001133 ! methane biosynthetic process from methanethiol + +[Term] +id: GO:1900346 +name: negative regulation of methane biosynthetic process from methanethiol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie] +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001133 ! methane biosynthetic process from methanethiol + +[Term] +id: GO:1900347 +name: positive regulation of methane biosynthetic process from methanethiol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methanethiol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from methanethiol" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from methanethiol" EXACT [GOC:TermGenie] +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900345 ! regulation of methane biosynthetic process from methanethiol +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001133 ! methane biosynthetic process from methanethiol + +[Term] +id: GO:1900348 +name: regulation of methane biosynthetic process from methylamine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0043457 ! regulation of cellular respiration +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:2001128 ! methane biosynthetic process from methylamine + +[Term] +id: GO:1900349 +name: negative regulation of methane biosynthetic process from methylamine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +synonym: "down-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +synonym: "downregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +synonym: "inhibition of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +is_a: GO:1901856 ! negative regulation of cellular respiration +relationship: negatively_regulates GO:2001128 ! methane biosynthetic process from methylamine + +[Term] +id: GO:1900350 +name: positive regulation of methane biosynthetic process from methylamine +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methane biosynthetic process from methylamine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methane biosynthetic process from methylamine" NARROW [GOC:TermGenie] +synonym: "up regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +synonym: "up-regulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +synonym: "upregulation of methane biosynthetic process from methylamine" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900348 ! regulation of methane biosynthetic process from methylamine +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +is_a: GO:1901857 ! positive regulation of cellular respiration +relationship: positively_regulates GO:2001128 ! methane biosynthetic process from methylamine + +[Term] +id: GO:1900351 +name: regulation of methanofuran biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +is_a: GO:1900354 ! regulation of methanofuran metabolic process +relationship: regulates GO:2001120 ! methanofuran biosynthetic process + +[Term] +id: GO:1900352 +name: negative regulation of methanofuran biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of methanofuran biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045863 ! negative regulation of pteridine metabolic process +is_a: GO:1900351 ! regulation of methanofuran biosynthetic process +is_a: GO:1900355 ! negative regulation of methanofuran metabolic process +relationship: negatively_regulates GO:2001120 ! methanofuran biosynthetic process + +[Term] +id: GO:1900353 +name: positive regulation of methanofuran biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of methanofuran biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methanofuran biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of methanofuran biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045864 ! positive regulation of pteridine metabolic process +is_a: GO:1900351 ! regulation of methanofuran biosynthetic process +is_a: GO:1900356 ! positive regulation of methanofuran metabolic process +relationship: positively_regulates GO:2001120 ! methanofuran biosynthetic process + +[Term] +id: GO:1900354 +name: regulation of methanofuran metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:2001119 ! methanofuran metabolic process + +[Term] +id: GO:1900355 +name: negative regulation of methanofuran metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of methanofuran metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900354 ! regulation of methanofuran metabolic process +relationship: negatively_regulates GO:2001119 ! methanofuran metabolic process + +[Term] +id: GO:1900356 +name: positive regulation of methanofuran metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methanofuran metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methanofuran metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanofuran metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of methanofuran metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methanofuran metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900354 ! regulation of methanofuran metabolic process +relationship: positively_regulates GO:2001119 ! methanofuran metabolic process + +[Term] +id: GO:1900357 +name: regulation of nigerotriose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001091 ! nigerotriose transport + +[Term] +id: GO:1900358 +name: negative regulation of nigerotriose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of nigerotriose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of nigerotriose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of nigerotriose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of nigerotriose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900357 ! regulation of nigerotriose transport +relationship: negatively_regulates GO:2001091 ! nigerotriose transport + +[Term] +id: GO:1900359 +name: positive regulation of nigerotriose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nigerotriose transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of nigerotriose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of nigerotriose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of nigerotriose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of nigerotriose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900357 ! regulation of nigerotriose transport +relationship: positively_regulates GO:2001091 ! nigerotriose transport + +[Term] +id: GO:1900360 +name: regulation of pentasaccharide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:2001100 ! pentasaccharide transport + +[Term] +id: GO:1900361 +name: negative regulation of pentasaccharide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of pentasaccharide transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of pentasaccharide transport" EXACT [GOC:TermGenie] +synonym: "downregulation of pentasaccharide transport" EXACT [GOC:TermGenie] +synonym: "inhibition of pentasaccharide transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1900360 ! regulation of pentasaccharide transport +relationship: negatively_regulates GO:2001100 ! pentasaccharide transport + +[Term] +id: GO:1900362 +name: positive regulation of pentasaccharide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pentasaccharide transport." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of pentasaccharide transport" NARROW [GOC:TermGenie] +synonym: "up regulation of pentasaccharide transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of pentasaccharide transport" EXACT [GOC:TermGenie] +synonym: "upregulation of pentasaccharide transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1900360 ! regulation of pentasaccharide transport +relationship: positively_regulates GO:2001100 ! pentasaccharide transport + +[Term] +id: GO:1900363 +name: regulation of mRNA polyadenylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] +synonym: "regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +is_a: GO:0031440 ! regulation of mRNA 3'-end processing +relationship: regulates GO:0006378 ! mRNA polyadenylation + +[Term] +id: GO:1900364 +name: negative regulation of mRNA polyadenylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] +synonym: "down regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "down regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "downregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "downregulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "inhibition of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA polyadenylation" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA polyadenylylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +is_a: GO:0031441 ! negative regulation of mRNA 3'-end processing +is_a: GO:1900363 ! regulation of mRNA polyadenylation +relationship: negatively_regulates GO:0006378 ! mRNA polyadenylation + +[Term] +id: GO:1900365 +name: positive regulation of mRNA polyadenylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA polyadenylation." [GOC:se, GOC:TermGenie, PMID:15121841] +synonym: "activation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "activation of mRNA polyadenylation" NARROW [GOC:TermGenie] +synonym: "activation of mRNA polyadenylylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "up regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "up regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +synonym: "upregulation of cleavage and polyadenylylation specificity factor activity" NARROW [GOC:TermGenie] +synonym: "upregulation of mRNA polyadenylation" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA polyadenylylation" EXACT [GOC:TermGenie] +is_a: GO:0031442 ! positive regulation of mRNA 3'-end processing +is_a: GO:1900363 ! regulation of mRNA polyadenylation +relationship: positively_regulates GO:0006378 ! mRNA polyadenylation + +[Term] +id: GO:1900366 +name: negative regulation of defense response to insect +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] +synonym: "down regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "down regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "down-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "downregulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "inhibition of defense response to insect" NARROW [GOC:TermGenie] +synonym: "inhibition of physiological defense response to insect" NARROW [GOC:TermGenie] +synonym: "negative regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "susceptibility to insect" RELATED [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:2000068 ! regulation of defense response to insect +relationship: negatively_regulates GO:0002213 ! defense response to insect + +[Term] +id: GO:1900367 +name: positive regulation of defense response to insect +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of defense response to insect." [GOC:TermGenie, PMID:22474183] +synonym: "activation of defense response to insect" NARROW [GOC:TermGenie] +synonym: "activation of physiological defense response to insect" NARROW [GOC:TermGenie] +synonym: "positive regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "up regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "up-regulation of physiological defense response to insect" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to insect" EXACT [GOC:TermGenie] +synonym: "upregulation of physiological defense response to insect" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:2000068 ! regulation of defense response to insect +relationship: positively_regulates GO:0002213 ! defense response to insect + +[Term] +id: GO:1900368 +name: regulation of RNA interference +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] +synonym: "regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "regulation of RNAi" EXACT [GOC:TermGenie] +is_a: GO:0060147 ! regulation of posttranscriptional gene silencing +is_a: GO:0060966 ! regulation of gene silencing by RNA +relationship: regulates GO:0016246 ! RNA interference + +[Term] +id: GO:1900369 +name: negative regulation of RNA interference +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] +synonym: "down regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "down regulation of RNAi" EXACT [GOC:TermGenie] +synonym: "down-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNAi" EXACT [GOC:TermGenie] +synonym: "downregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "downregulation of RNAi" EXACT [GOC:TermGenie] +synonym: "inhibition of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA interference" NARROW [GOC:TermGenie] +synonym: "inhibition of RNAi" EXACT [GOC:TermGenie] +synonym: "negative regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNAi" EXACT [GOC:TermGenie] +is_a: GO:0060149 ! negative regulation of posttranscriptional gene silencing +is_a: GO:0060967 ! negative regulation of gene silencing by RNA +is_a: GO:1900368 ! regulation of RNA interference +relationship: negatively_regulates GO:0016246 ! RNA interference + +[Term] +id: GO:1900370 +name: positive regulation of RNA interference +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA interference." [GOC:kmv, GOC:TermGenie, PMID:22412382] +synonym: "activation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "activation of RNA interference" NARROW [GOC:TermGenie] +synonym: "activation of RNAi" EXACT [GOC:TermGenie] +synonym: "positive regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNAi" EXACT [GOC:TermGenie] +synonym: "up regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "up regulation of RNAi" EXACT [GOC:TermGenie] +synonym: "up-regulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNAi" EXACT [GOC:TermGenie] +synonym: "upregulation of posttranscriptional gene silencing by siRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA interference" EXACT [GOC:TermGenie] +synonym: "upregulation of RNAi" EXACT [GOC:TermGenie] +is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing +is_a: GO:1900368 ! regulation of RNA interference +relationship: positively_regulates GO:0016246 ! RNA interference + +[Term] +id: GO:1900371 +name: regulation of purine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] +synonym: "regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +relationship: regulates GO:0006164 ! purine nucleotide biosynthetic process + +[Term] +id: GO:1900372 +name: negative regulation of purine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] +synonym: "down regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "inhibition of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +relationship: negatively_regulates GO:0006164 ! purine nucleotide biosynthetic process + +[Term] +id: GO:1900373 +name: positive regulation of purine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide biosynthetic processes." [GOC:go_curators, GOC:TermGenie] +synonym: "activation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +relationship: positively_regulates GO:0006164 ! purine nucleotide biosynthetic process + +[Term] +id: GO:1900374 +name: obsolete positive regulation of mating type switching by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:go_curators, GOC:TermGenie, PMID:8804308] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "stimulation of mating type switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of mating type switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900375 +name: obsolete positive regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of inositol biosynthetic process." [GOC:go_curators, GOC:TermGenie, PMID:2004420] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of myo-inositol biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of myo-inositol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of vitamin Bh biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin Bh biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900376 +name: regulation of secondary metabolite biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:1900377 +name: negative regulation of secondary metabolite biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:1900378 +name: positive regulation of secondary metabolite biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of secondary metabolite biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of secondary metabolite biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of secondary metabolite biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: positively_regulates GO:0044550 ! secondary metabolite biosynthetic process + +[Term] +id: GO:1900379 +name: regulation of asperthecin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0036184 ! asperthecin biosynthetic process + +[Term] +id: GO:1900380 +name: negative regulation of asperthecin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of asperthecin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900379 ! regulation of asperthecin biosynthetic process +relationship: negatively_regulates GO:0036184 ! asperthecin biosynthetic process + +[Term] +id: GO:1900381 +name: positive regulation of asperthecin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of asperthecin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "activation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperthecin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of asperthecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of asperthecin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of asperthecin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of asperthecin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900379 ! regulation of asperthecin biosynthetic process +relationship: positively_regulates GO:0036184 ! asperthecin biosynthetic process + +[Term] +id: GO:1900382 +name: obsolete regulation of thiamine biosynthetic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of thiamine biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16874521] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of thiamin biosynthetic process by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of thiamine anabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of thiamine biosynthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of thiamine formation by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of thiamine synthesis by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900383 +name: regulation of synaptic plasticity by receptor localization to synapse +namespace: biological_process +def: "Any process that modulates synaptic plasticity, the ability of synapses to change as circumstances require, via receptor localization to the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. Processes may include receptor transport to, and/or maintenance at, the synapse." [GOC:kmv, GOC:TermGenie, PMID:22464329] +synonym: "regulation of synaptic plasticity by receptor localisation to synapse" EXACT [GOC:TermGenie] +is_a: GO:0097120 ! receptor localization to synapse + +[Term] +id: GO:1900384 +name: regulation of flavonol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] +is_a: GO:0009962 ! regulation of flavonoid biosynthetic process +relationship: regulates GO:0051555 ! flavonol biosynthetic process + +[Term] +id: GO:1900385 +name: negative regulation of flavonol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of flavonol biosynthetic process" NARROW [GOC:TermGenie] +is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process +is_a: GO:1900384 ! regulation of flavonol biosynthetic process +relationship: negatively_regulates GO:0051555 ! flavonol biosynthetic process + +[Term] +id: GO:1900386 +name: positive regulation of flavonol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of flavonol biosynthetic process." [GOC:TermGenie] +synonym: "activation of flavonol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of flavonol biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process +is_a: GO:1900384 ! regulation of flavonol biosynthetic process +relationship: positively_regulates GO:0051555 ! flavonol biosynthetic process + +[Term] +id: GO:1900387 +name: obsolete negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cell-cell adhesion." [GOC:BHF, GOC:TermGenie, PMID:15737616] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900388 +name: obsolete regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of vesicle-mediated transport." [GOC:mah, GOC:TermGenie, PMID:18622392] +comment: This term was made obsolete because there is no evidence that vesicle-mediated transport is regulated transcriptionally. +synonym: "regulation of vesicle-mediated transport by regulation of transcription from RNA polymerase II promoter" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900389 +name: obsolete regulation of glucose import by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of glucose import." [GOC:mah, GOC:TermGenie, PMID:18622392] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of glucose uptake by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900391 +name: obsolete regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cAMP-mediated signaling." [GOC:mah, GOC:TermGenie, PMID:15448137] +comment: The reason for obsoletion is that cAMP-mediated signaling is not mediated by transcription from RNA polII promoter. +synonym: "regulation of cAMP-mediated signalling by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900392 +name: obsolete regulation of transport by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in regulation of transport." [GOC:mah, GOC:TermGenie, PMID:17446861] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900394 +name: regulation of kojic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:2001317 ! kojic acid biosynthetic process + +[Term] +id: GO:1900395 +name: negative regulation of kojic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "down regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "downregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "inhibition of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "inhibition of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of kojic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "inhibition of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900394 ! regulation of kojic acid biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:2001317 ! kojic acid biosynthetic process + +[Term] +id: GO:1900396 +name: positive regulation of kojic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of kojic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "activation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "activation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "activation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "activation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "activation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "activation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of kojic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "activation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "up regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of kojic acid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of C6H6O4 anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of C6H6O4 biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of C6H6O4 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of C6H6O4 formation" RELATED [GOC:TermGenie] +synonym: "upregulation of C6H6O4 synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of kojic acid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of kojic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of kojic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of kojic acid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of kojic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900394 ! regulation of kojic acid biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:2001317 ! kojic acid biosynthetic process + +[Term] +id: GO:1900397 +name: regulation of pyrimidine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] +synonym: "regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +relationship: regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process + +[Term] +id: GO:1900398 +name: negative regulation of pyrimidine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "inhibition of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process +is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process +relationship: negatively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process + +[Term] +id: GO:1900399 +name: positive regulation of pyrimidine nucleotide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pyrimidine nucleotide biosynthetic process." [GOC:TermGenie] +synonym: "activation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "activation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of pyrimidine nucleotide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "activation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine nucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine nucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine nucleotide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine nucleotide formation" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine nucleotide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process +is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process +relationship: positively_regulates GO:0006221 ! pyrimidine nucleotide biosynthetic process + +[Term] +id: GO:1900400 +name: regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +alt_id: GO:1900393 +def: "A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import." [GOC:mah, GOC:TermGenie, PMID:18622392] +synonym: "regulation of iron import by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of iron ion import by regulation of transcription from RNA polymerase II promoter" RELATED [] +synonym: "regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter" BROAD [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0034756 ! regulation of iron ion transport +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0033212 ! iron import into cell + +[Term] +id: GO:1900402 +name: obsolete regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of carbohydrate metabolic process." [GOC:mah, GOC:TermGenie, PMID:16408318] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of carbohydrate metabolism by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900403 +name: obsolete negative regulation of cellular amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of cellular amino acid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:17446861] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of amino acid biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular amino acid anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular amino acid biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular amino acid formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular amino acid synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900404 +name: positive regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of DNA repair." [GOC:mah, GOC:TermGenie, PMID:20299455] +synonym: "activation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "stimulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA repair by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0045739 ! positive regulation of DNA repair +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: positively_regulates GO:0100026 ! positive regulation of DNA repair by transcription from RNA polymerase II promoter + +[Term] +id: GO:1900405 +name: obsolete regulation of cell separation after cytokinesis by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cell separation after cytokinesis." [GOC:mah, GOC:TermGenie, PMID:10491317, PMID:12665550] +synonym: "regulation of cytokinetic cell separation by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900406 +name: obsolete regulation of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of conjugation with cellular fusion." [GOC:mah, GOC:TermGenie, PMID:1112904] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900407 +name: regulation of cellular response to oxidative stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] +synonym: "regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +is_a: GO:0080135 ! regulation of cellular response to stress +is_a: GO:1902882 ! regulation of response to oxidative stress +relationship: regulates GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:1900408 +name: negative regulation of cellular response to oxidative stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] +synonym: "down regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "down regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "down-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "downregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "inhibition of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1900407 ! regulation of cellular response to oxidative stress +is_a: GO:1902883 ! negative regulation of response to oxidative stress +relationship: negatively_regulates GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:1900409 +name: positive regulation of cellular response to oxidative stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie] +synonym: "activation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "up regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "up-regulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of adaptive response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "upregulation of cellular response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1900407 ! regulation of cellular response to oxidative stress +is_a: GO:1902884 ! positive regulation of response to oxidative stress +relationship: positively_regulates GO:0034599 ! cellular response to oxidative stress + +[Term] +id: GO:1900410 +name: obsolete regulation of histone modification by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone modification." [GOC:mah, GOC:TermGenie] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:1900411 +name: obsolete regulation of histone acetylation by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone acetylation." [GOC:mah, GOC:TermGenie, PMID:15218150] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:1900412 +name: obsolete regulation of histone methylation by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of histone methylation." [GOC:mah, GOC:TermGenie, PMID:15218150] +comment: This term was obsoleted because it describes a process that does not exist. +is_obsolete: true + +[Term] +id: GO:1900413 +name: obsolete positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of phospholipid biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:16537923] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of phospholipid biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phospholipid synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900414 +name: obsolete regulation of cytokinesis by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cytokinesis." [GOC:mah, GOC:TermGenie, PMID:15509866] +is_obsolete: true + +[Term] +id: GO:1900415 +name: obsolete regulation of fungal-type cell wall biogenesis by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of fungal-type cell wall biogenesis." [GOC:mah, GOC:TermGenie, PMID:15509866] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900416 +name: obsolete regulation of 4,6-pyruvylated galactose residue biosynthetic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of 4,6-pyruvylated galactose residue biosynthetic process." [GOC:mah, GOC:TermGenie, PMID:15173185] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900417 +name: obsolete negative regulation of transmembrane transport by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of transmembrane transport." [GOC:mah, GOC:TermGenie, PMID:20404084] +comment: The term was obsoleted because it is better represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900418 +name: obsolete positive regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of purine nucleotide biosynthetic process." [GOC:curators, GOC:TermGenie, PMID:17573544] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900419 +name: regulation of cellular alcohol catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0044109 ! cellular alcohol catabolic process + +[Term] +id: GO:1900420 +name: negative regulation of cellular alcohol catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] +synonym: "down regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular alcohol catabolic process" NARROW [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900419 ! regulation of cellular alcohol catabolic process +relationship: negatively_regulates GO:0044109 ! cellular alcohol catabolic process + +[Term] +id: GO:1900421 +name: positive regulation of cellular alcohol catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular alcohol catabolic process." [GOC:TermGenie] +synonym: "activation of cellular alcohol catabolic process" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular alcohol catabolic process" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900419 ! regulation of cellular alcohol catabolic process +relationship: positively_regulates GO:0044109 ! cellular alcohol catabolic process + +[Term] +id: GO:1900422 +name: obsolete positive regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of cellular alcohol catabolic process." [GOC:curators, GOC:TermGenie, PMID:3305157, PMID:8221926] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular alcohol catabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900423 +name: obsolete positive regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of mating type switching." [GOC:TermGenie, PMID:8804308] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "stimulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of mating type switching by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900424 +name: regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902477 +def: "Any process that modulates the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "regulation of defence response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "regulation of defense response to bacterium, incompatible interaction" NARROW [] +synonym: "regulation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "regulation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0042742 ! defense response to bacterium + +[Term] +id: GO:1900425 +name: negative regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902478 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "down regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "down regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "down regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "down regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "down regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "down-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "down-regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "downregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "downregulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "downregulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "inhibition of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "inhibition of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "inhibition of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "inhibition of defence response to pathogenic bacteria, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of defence response to pathogenic bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "inhibition of defense response to bacterium" NARROW [GOC:TermGenie] +synonym: "inhibition of defense response to bacterium, incompatible interaction" NARROW [GOC:TermGenie] +synonym: "inhibition of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "inhibition of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +synonym: "inhibition of response to pathogenic bacteria (incompatible interaction)" NARROW [GOC:TermGenie] +synonym: "inhibition of response to pathogenic bacterium (incompatible interaction)" NARROW [GOC:TermGenie] +synonym: "negative regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "negative regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "negative regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "negative regulation of defense response to bacterium, incompatible interaction" NARROW [] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1900424 ! regulation of defense response to bacterium +relationship: negatively_regulates GO:0042742 ! defense response to bacterium + +[Term] +id: GO:1900426 +name: positive regulation of defense response to bacterium +namespace: biological_process +alt_id: GO:1902479 +def: "Any process that activates or increases the frequency, rate or extent of defense response to bacterium." [GOC:TermGenie, PMID:22346749] +synonym: "activation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "activation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "activation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "activation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "activation of defense response to bacterium" NARROW [GOC:TermGenie] +synonym: "activation of resistance response to pathogenic bacteria" NARROW [GOC:TermGenie] +synonym: "activation of resistance response to pathogenic bacterium" NARROW [GOC:TermGenie] +synonym: "positive regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "positive regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of defense response to bacterium, incompatible interaction" NARROW [] +synonym: "up regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "upregulation of defence response to bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of defence response to bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to bacterium" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1900424 ! regulation of defense response to bacterium +relationship: positively_regulates GO:0042742 ! defense response to bacterium + +[Term] +id: GO:1900427 +name: obsolete regulation of cellular response to oxidative stress by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of cellular response to oxidative stress." [GOC:mah, GOC:TermGenie, PMID:10348908] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of adaptive response to oxidative stress by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900428 +name: regulation of filamentous growth of a population of unicellular organisms +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] +is_a: GO:0010570 ! regulation of filamentous growth +relationship: regulates GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:1900429 +name: negative regulation of filamentous growth of a population of unicellular organisms +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie] +is_a: GO:0060258 ! negative regulation of filamentous growth +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: negatively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:1900430 +name: positive regulation of filamentous growth of a population of unicellular organisms +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms" EXACT [GOC:TermGenie] +is_a: GO:0090033 ! positive regulation of filamentous growth +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: positively_regulates GO:0044182 ! filamentous growth of a population of unicellular organisms + +[Term] +id: GO:1900431 +name: regulation of filamentous growth of a population of unicellular organisms in response to heat +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] +is_a: GO:0080134 ! regulation of response to stress +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat + +[Term] +id: GO:1900432 +name: negative regulation of filamentous growth of a population of unicellular organisms in response to heat +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat +relationship: negatively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat + +[Term] +id: GO:1900433 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to heat +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to heat." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to heat" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to heat" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900431 ! regulation of filamentous growth of a population of unicellular organisms in response to heat +relationship: positively_regulates GO:0036168 ! filamentous growth of a population of unicellular organisms in response to heat + +[Term] +id: GO:1900434 +name: regulation of filamentous growth of a population of unicellular organisms in response to starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080134 ! regulation of response to stress +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation + +[Term] +id: GO:1900435 +name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900436 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to starvation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to starvation" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to starvation" EXACT [GOC:TermGenie] +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900434 ! regulation of filamentous growth of a population of unicellular organisms in response to starvation +relationship: positively_regulates GO:0036170 ! filamentous growth of a population of unicellular organisms in response to starvation + +[Term] +id: GO:1900437 +name: regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus + +[Term] +id: GO:1900438 +name: negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus +relationship: negatively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus + +[Term] +id: GO:1900439 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900437 ! regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus +relationship: positively_regulates GO:0036171 ! filamentous growth of a population of unicellular organisms in response to chemical stimulus + +[Term] +id: GO:1900440 +name: regulation of filamentous growth of a population of unicellular organisms in response to neutral pH +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] +is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH +relationship: regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH + +[Term] +id: GO:1900441 +name: negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie] +is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH +is_a: GO:1900742 ! negative regulation of filamentous growth of a population of unicellular organisms in response to pH +relationship: negatively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH + +[Term] +id: GO:1900442 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to neutral pH." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to neutral pH" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to neutral pH" EXACT [GOC:TermGenie] +is_a: GO:1900440 ! regulation of filamentous growth of a population of unicellular organisms in response to neutral pH +is_a: GO:1900743 ! positive regulation of filamentous growth of a population of unicellular organisms in response to pH +relationship: positively_regulates GO:0036178 ! filamentous growth of a population of unicellular organisms in response to neutral pH + +[Term] +id: GO:1900443 +name: regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus + +[Term] +id: GO:1900444 +name: negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus +relationship: negatively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus + +[Term] +id: GO:1900445 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to biotic stimulus." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900443 ! regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus +relationship: positively_regulates GO:0036180 ! filamentous growth of a population of unicellular organisms in response to biotic stimulus + +[Term] +id: GO:1900446 +name: obsolete negative regulation of tRNA transcription from RNA polymerase III promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of tRNA transcription from RNA polymerase III promoter." [GOC:sart, GOC:TermGenie] +comment: The reason for obsoletion is that there is no specific regulator for negatively regulating tRNA transcription which is separable from general negative regulation of transcription from RNA polymerase III. +synonym: "down regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of tRNA transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of tRNA transcription from Pol III promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900447 +name: regulation of cell morphogenesis involved in phenotypic switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing a phenotypic switch. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells, such as the opaque cells of C. albicans, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:di, GOC:TermGenie] +synonym: "negative regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "negative regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] +synonym: "regulation of cell morphogenesis of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of cell morphogenesis of phenotypic switching" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape and cell size of phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of cell shape and cell size of phenotypic switching" RELATED [GOC:TermGenie] +is_a: GO:0022604 ! regulation of cell morphogenesis +relationship: part_of GO:0036166 ! phenotypic switching + +[Term] +id: GO:1900448 +name: obsolete regulation of pyrimidine nucleotide biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of pyrimidine nucleotide biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900449 +name: regulation of glutamate receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007215 ! glutamate receptor signaling pathway + +[Term] +id: GO:1900450 +name: negative regulation of glutamate receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway +relationship: negatively_regulates GO:0007215 ! glutamate receptor signaling pathway + +[Term] +id: GO:1900451 +name: positive regulation of glutamate receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "activation of glutamate receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "activation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamate receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamate signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamate signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900449 ! regulation of glutamate receptor signaling pathway +relationship: positively_regulates GO:0007215 ! glutamate receptor signaling pathway + +[Term] +id: GO:1900452 +name: regulation of long-term synaptic depression +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "regulation of long term synaptic depression" EXACT [] +synonym: "regulation of LTD" RELATED [GOC:TermGenie] +is_a: GO:0048167 ! regulation of synaptic plasticity +relationship: regulates GO:0060292 ! long-term synaptic depression + +[Term] +id: GO:1900453 +name: negative regulation of long-term synaptic depression +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "down regulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "down regulation of LTD" RELATED [GOC:TermGenie] +synonym: "down-regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "down-regulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "down-regulation of LTD" RELATED [GOC:TermGenie] +synonym: "downregulation of long term depression" BROAD [GOC:TermGenie] +synonym: "downregulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "downregulation of LTD" RELATED [GOC:TermGenie] +synonym: "inhibition of long term depression" BROAD [GOC:TermGenie] +synonym: "inhibition of long term synaptic depression" NARROW [GOC:TermGenie] +synonym: "inhibition of LTD" RELATED [GOC:TermGenie] +synonym: "negative regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "negative regulation of long term synaptic depression" RELATED [] +synonym: "negative regulation of LTD" RELATED [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0050806 ! positive regulation of synaptic transmission +is_a: GO:1900452 ! regulation of long-term synaptic depression +relationship: negatively_regulates GO:0060292 ! long-term synaptic depression + +[Term] +id: GO:1900454 +name: positive regulation of long-term synaptic depression +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of long term synaptic depression." [GOC:BHF, GOC:TermGenie] +synonym: "activation of long term depression" BROAD [GOC:TermGenie] +synonym: "activation of long term synaptic depression" NARROW [GOC:TermGenie] +synonym: "activation of LTD" RELATED [GOC:TermGenie] +synonym: "positive regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "positive regulation of long term synaptic depression" EXACT [] +synonym: "positive regulation of LTD" RELATED [GOC:TermGenie] +synonym: "up regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "up regulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "up regulation of LTD" RELATED [GOC:TermGenie] +synonym: "up-regulation of long term depression" BROAD [GOC:TermGenie] +synonym: "up-regulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "up-regulation of LTD" RELATED [GOC:TermGenie] +synonym: "upregulation of long term depression" BROAD [GOC:TermGenie] +synonym: "upregulation of long term synaptic depression" EXACT [GOC:TermGenie] +synonym: "upregulation of LTD" RELATED [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1900452 ! regulation of long-term synaptic depression +relationship: positively_regulates GO:0060292 ! long-term synaptic depression + +[Term] +id: GO:1900456 +name: obsolete regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10373537, PMID:10591965, PMID:12024013, PMID:15466424, PMID:16568252, PMID:8710886, PMID:9811878, PMID:9987114] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of colony morphology by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of invasive growth in response to glucose limitation by regulation of transcription from RNA polymerase II promoter" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900457 +name: regulation of brassinosteroid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] +synonym: "regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009742 ! brassinosteroid mediated signaling pathway + +[Term] +id: GO:1900458 +name: negative regulation of brassinosteroid mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] +synonym: "down regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "down-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "downregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "inhibition of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway +relationship: negatively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway + +[Term] +id: GO:1900459 +name: positive regulation of brassinosteroid mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid mediated signaling pathway." [GOC:TermGenie, PMID:21855796] +synonym: "activation of brassinosteroid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "positive regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "up regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "up-regulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +synonym: "upregulation of brassinosteroid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of brassinosteroid mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900457 ! regulation of brassinosteroid mediated signaling pathway +relationship: positively_regulates GO:0009742 ! brassinosteroid mediated signaling pathway + +[Term] +id: GO:1900460 +name: obsolete negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024013, PMID:15466424, PMID:9811878] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of colony morphology by negative regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900461 +name: positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:11046133, PMID:8710886, PMID:9987114] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:2000222 ! positive regulation of pseudohyphal growth + +[Term] +id: GO:1900462 +name: obsolete negative regulation of pseudohyphal growth by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12024012, PMID:9811878] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900463 +name: negative regulation of cellular response to alkaline pH by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular response to alkalinity by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:12509465, PMID:17023428] +synonym: "negative regulation of cellular response to alkalinity by negative regulation of transcription from RNA polymerase II promoter" BROAD [] +synonym: "negative regulation of cellular response to basic pH by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:1900068 ! negative regulation of cellular response to alkaline pH + +[Term] +id: GO:1900464 +name: negative regulation of cellular hyperosmotic salinity response by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular hyperosmotic salinity response by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:16278455] +synonym: "negative regulation of cellular response to hyperosmotic salt stress by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:1900070 ! negative regulation of cellular hyperosmotic salinity response + +[Term] +id: GO:1900465 +name: obsolete negative regulation of arginine catabolic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cellular arginine catabolic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of arginine breakdown by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of arginine catabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of arginine degradation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900466 +name: obsolete positive regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of arginine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19233144, PMID:8455631] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900467 +name: obsolete regulation of cellular potassium ion homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cellular potassium ion homeostasis." [GOC:dgf, GOC:TermGenie, PMID:20412803] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of cellular potassium ion homeostasis" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900468 +name: regulation of phosphatidylserine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +synonym: "regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +is_a: GO:0150178 ! regulation of phosphatidylserine metabolic process +relationship: regulates GO:0006659 ! phosphatidylserine biosynthetic process + +[Term] +id: GO:1900469 +name: negative regulation of phosphatidylserine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +synonym: "down regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +is_a: GO:0150180 ! negative regulation of phosphatidylserine metabolic process +is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process +relationship: negatively_regulates GO:0006659 ! phosphatidylserine biosynthetic process + +[Term] +id: GO:1900470 +name: positive regulation of phosphatidylserine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +synonym: "activation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +is_a: GO:0150179 ! positive regulation of phosphatidylserine metabolic process +is_a: GO:1900468 ! regulation of phosphatidylserine biosynthetic process +relationship: positively_regulates GO:0006659 ! phosphatidylserine biosynthetic process + +[Term] +id: GO:1900471 +name: obsolete negative regulation of inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of inositol biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of inositol anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of inositol synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of myo-inositol biosynthesis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of myo-inositol biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of vitamin Bh biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of vitamin Bh biosynthetic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900472 +name: obsolete positive regulation of phosphatidylcholine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of phosphatidylcholine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylcholine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylcholine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylcholine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900473 +name: obsolete negative regulation of phosphatidylcholine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of phosphatidylcholine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylcholine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylcholine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylcholine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900474 +name: obsolete negative regulation of mating type switching by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8625408, PMID:8625409] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1900477 +name: negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:19841732] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle + +[Term] +id: GO:1900478 +name: obsolete positive regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of sulfate assimilation by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:7601277, PMID:7891681] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "activation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up-regulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up-regulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of sulfate assimilation by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "upregulation of sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "upregulation of sulphate assimilation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900480 +name: regulation of diacylglycerol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] +synonym: "regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:0006651 ! diacylglycerol biosynthetic process + +[Term] +id: GO:1900481 +name: negative regulation of diacylglycerol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process +relationship: negatively_regulates GO:0006651 ! diacylglycerol biosynthetic process + +[Term] +id: GO:1900482 +name: positive regulation of diacylglycerol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol biosynthetic process." [GOC:TermGenie] +synonym: "activation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of diacylglycerol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "activation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1900480 ! regulation of diacylglycerol biosynthetic process +relationship: positively_regulates GO:0006651 ! diacylglycerol biosynthetic process + +[Term] +id: GO:1900483 +name: regulation of protein targeting to vacuolar membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] +is_a: GO:0090313 ! regulation of protein targeting to membrane +is_a: GO:1903335 ! regulation of vacuolar transport +relationship: regulates GO:0044395 ! protein targeting to vacuolar membrane + +[Term] +id: GO:1900484 +name: negative regulation of protein targeting to vacuolar membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] +synonym: "down regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie] +is_a: GO:0090315 ! negative regulation of protein targeting to membrane +is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane +is_a: GO:1903336 ! negative regulation of vacuolar transport +relationship: negatively_regulates GO:0044395 ! protein targeting to vacuolar membrane + +[Term] +id: GO:1900485 +name: positive regulation of protein targeting to vacuolar membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane." [GOC:TermGenie] +synonym: "activation of protein targeting to vacuolar membrane" NARROW [GOC:TermGenie] +synonym: "up regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein targeting to vacuolar membrane" EXACT [GOC:TermGenie] +is_a: GO:0090314 ! positive regulation of protein targeting to membrane +is_a: GO:1900483 ! regulation of protein targeting to vacuolar membrane +is_a: GO:1903337 ! positive regulation of vacuolar transport +relationship: positively_regulates GO:0044395 ! protein targeting to vacuolar membrane + +[Term] +id: GO:1900486 +name: positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:TermGenie] +synonym: "activation of Ac-MVA pathway" EXACT [GOC:TermGenie] +synonym: "activation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "activation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" NARROW [GOC:TermGenie] +synonym: "activation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "activation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Ac-MVA pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Ac-MVA pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of acetate-mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:TermGenie] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway +relationship: positively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway + +[Term] +id: GO:1900487 +name: regulation of [2Fe-2S] cluster assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] +synonym: "regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly +relationship: regulates GO:0044571 ! [2Fe-2S] cluster assembly + +[Term] +id: GO:1900488 +name: negative regulation of [2Fe-2S] cluster assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly +is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly +relationship: negatively_regulates GO:0044571 ! [2Fe-2S] cluster assembly + +[Term] +id: GO:1900489 +name: positive regulation of [2Fe-2S] cluster assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of [2Fe-2S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] +synonym: "activation of 2Fe-2S cluster assembly" NARROW [GOC:TermGenie] +synonym: "activation of [2Fe-2S] cluster assembly" NARROW [GOC:TermGenie] +synonym: "activation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of 2Fe-2S cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of [2Fe-2S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of [2Fe-2S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1900487 ! regulation of [2Fe-2S] cluster assembly +is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly +relationship: positively_regulates GO:0044571 ! [2Fe-2S] cluster assembly + +[Term] +id: GO:1900490 +name: obsolete positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:TermGenie] +comment: This term has been obsoleted because it represents a molecular function. +synonym: "activation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] +synonym: "activation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] +synonym: "activation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] +synonym: "positive regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] +synonym: "up regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] +synonym: "up regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] +synonym: "up regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] +synonym: "up-regulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] +synonym: "up-regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [GOC:TermGenie] +synonym: "upregulation of HMG-CoA reductase activity" BROAD [GOC:TermGenie] +synonym: "upregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0008047 +consider: GO:0106109 + +[Term] +id: GO:1900491 +name: regulation of [4Fe-4S] cluster assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] +synonym: "regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly +relationship: regulates GO:0044572 ! [4Fe-4S] cluster assembly + +[Term] +id: GO:1900492 +name: negative regulation of [4Fe-4S] cluster assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] +synonym: "down regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly +is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly +relationship: negatively_regulates GO:0044572 ! [4Fe-4S] cluster assembly + +[Term] +id: GO:1900493 +name: positive regulation of [4Fe-4S] cluster assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of [4Fe-4S] cluster assembly." [GOC:mengo_curators, GOC:pr, GOC:TermGenie] +synonym: "activation of 4Fe-4S cluster assembly" NARROW [GOC:TermGenie] +synonym: "activation of [4Fe-4S] cluster assembly" NARROW [GOC:TermGenie] +synonym: "activation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of 4Fe-4S cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of [4Fe-4S] cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of [4Fe-4S] cluster biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:1900491 ! regulation of [4Fe-4S] cluster assembly +is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly +relationship: positively_regulates GO:0044572 ! [4Fe-4S] cluster assembly + +[Term] +id: GO:1900494 +name: regulation of butyryl-CoA biosynthetic process from acetyl-CoA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process +relationship: regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA + +[Term] +id: GO:1900495 +name: negative regulation of butyryl-CoA biosynthetic process from acetyl-CoA +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "down regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie] +synonym: "negative regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process +is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA +relationship: negatively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA + +[Term] +id: GO:1900496 +name: positive regulation of butyryl-CoA biosynthetic process from acetyl-CoA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA biosynthetic process from acetyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "activation of butyryl-CoA biosynthetic process from acetyl-CoA" NARROW [GOC:TermGenie] +synonym: "positive regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA biosynthesis from acetyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA biosynthetic process from acetyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process +is_a: GO:1900494 ! regulation of butyryl-CoA biosynthetic process from acetyl-CoA +relationship: positively_regulates GO:0044579 ! butyryl-CoA biosynthetic process from acetyl-CoA + +[Term] +id: GO:1900497 +name: regulation of butyryl-CoA catabolic process to butanol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +is_a: GO:0019217 ! regulation of fatty acid metabolic process +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:0050994 ! regulation of lipid catabolic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0044582 ! butyryl-CoA catabolic process to butanol + +[Term] +id: GO:1900498 +name: negative regulation of butyryl-CoA catabolic process to butanol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "down regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "negative regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0045922 ! negative regulation of fatty acid metabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol + +[Term] +id: GO:1900499 +name: positive regulation of butyryl-CoA catabolic process to butanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of butyryl-CoA catabolic process to butanol" NARROW [GOC:TermGenie] +synonym: "activation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "positive regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA catabolic process to butanol" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA catabolism to butanol" EXACT [GOC:TermGenie] +is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0045923 ! positive regulation of fatty acid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900497 ! regulation of butyryl-CoA catabolic process to butanol +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0044582 ! butyryl-CoA catabolic process to butanol + +[Term] +id: GO:1900500 +name: regulation of butyryl-CoA catabolic process to butyrate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +is_a: GO:0033121 ! regulation of purine nucleotide catabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +relationship: regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate + +[Term] +id: GO:1900501 +name: negative regulation of butyryl-CoA catabolic process to butyrate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "down regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "down-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "downregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie] +synonym: "inhibition of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "negative regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +is_a: GO:0033122 ! negative regulation of purine nucleotide catabolic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate +relationship: negatively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate + +[Term] +id: GO:1900502 +name: positive regulation of butyryl-CoA catabolic process to butyrate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of butyryl-CoA catabolic process to butyrate" NARROW [GOC:TermGenie] +synonym: "activation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "positive regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "up regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "up-regulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA catabolic process to butyrate" EXACT [GOC:TermGenie] +synonym: "upregulation of butyryl-CoA catabolism to butyrate" EXACT [GOC:TermGenie] +is_a: GO:0033123 ! positive regulation of purine nucleotide catabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900500 ! regulation of butyryl-CoA catabolic process to butyrate +relationship: positively_regulates GO:0044581 ! butyryl-CoA catabolic process to butyrate + +[Term] +id: GO:1900503 +name: regulation of cellulosome assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0044575 ! cellulosome assembly + +[Term] +id: GO:1900504 +name: negative regulation of cellulosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of cellulosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellulosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cellulosome assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of cellulosome assembly" NARROW [GOC:TermGenie] +is_a: GO:1900503 ! regulation of cellulosome assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0044575 ! cellulosome assembly + +[Term] +id: GO:1900505 +name: positive regulation of cellulosome assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellulosome assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of cellulosome assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of cellulosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellulosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of cellulosome assembly" EXACT [GOC:TermGenie] +is_a: GO:1900503 ! regulation of cellulosome assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0044575 ! cellulosome assembly + +[Term] +id: GO:1900506 +name: regulation of iron-sulfur-molybdenum cofactor assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly +relationship: regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly + +[Term] +id: GO:1900507 +name: negative regulation of iron-sulfur-molybdenum cofactor assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly +is_a: GO:1903330 ! negative regulation of iron-sulfur cluster assembly +relationship: negatively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly + +[Term] +id: GO:1900508 +name: positive regulation of iron-sulfur-molybdenum cofactor assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur-molybdenum cofactor assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "activation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "activation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "activation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "activation of iron-sulfur-molybdenum cofactor assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of FeMoco assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of FeMoco biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of iron molybdenum cofactor assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of iron molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of iron molybdenum cofactor biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of iron-sulfur-molybdenum cofactor assembly" EXACT [GOC:TermGenie] +is_a: GO:1900506 ! regulation of iron-sulfur-molybdenum cofactor assembly +is_a: GO:1903331 ! positive regulation of iron-sulfur cluster assembly +relationship: positively_regulates GO:0044593 ! iron-sulfur-molybdenum cofactor assembly + +[Term] +id: GO:1900509 +name: regulation of pentose catabolic process to ethanol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0044576 ! pentose catabolic process to ethanol + +[Term] +id: GO:1900510 +name: negative regulation of pentose catabolic process to ethanol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "down regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "downregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "downregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "inhibition of pentose catabolic process to ethanol" NARROW [GOC:TermGenie] +synonym: "inhibition of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "negative regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0044576 ! pentose catabolic process to ethanol + +[Term] +id: GO:1900511 +name: positive regulation of pentose catabolic process to ethanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of pentose catabolic process to ethanol" NARROW [GOC:TermGenie] +synonym: "activation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "positive regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "up regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "up regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "upregulation of pentose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "upregulation of pentose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0044576 ! pentose catabolic process to ethanol + +[Term] +id: GO:1900512 +name: regulation of starch utilization system complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "regulation of SUS complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0044574 ! starch utilization system complex assembly + +[Term] +id: GO:1900513 +name: negative regulation of starch utilization system complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "down regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "down-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "downregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "inhibition of starch utilization system complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "negative regulation of SUS complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1900512 ! regulation of starch utilization system complex assembly +relationship: negatively_regulates GO:0044574 ! starch utilization system complex assembly + +[Term] +id: GO:1900514 +name: positive regulation of starch utilization system complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of starch utilization system complex assembly." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "activation of starch utilization system complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "positive regulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "up regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "up-regulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of SUS complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of assembly of starch utilization system complex" EXACT [GOC:TermGenie] +synonym: "upregulation of starch utilization system complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of SUS complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1900512 ! regulation of starch utilization system complex assembly +relationship: positively_regulates GO:0044574 ! starch utilization system complex assembly + +[Term] +id: GO:1900515 +name: regulation of xylose catabolic process to ethanol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:0043469 ! regulation of D-xylose catabolic process +is_a: GO:1900509 ! regulation of pentose catabolic process to ethanol +relationship: regulates GO:0044577 ! xylose catabolic process to ethanol + +[Term] +id: GO:1900516 +name: negative regulation of xylose catabolic process to ethanol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "down regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "downregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "downregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "inhibition of xylose catabolic process to ethanol" NARROW [GOC:TermGenie] +synonym: "inhibition of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "negative regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:1900510 ! negative regulation of pentose catabolic process to ethanol +is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol +relationship: negatively_regulates GO:0044577 ! xylose catabolic process to ethanol + +[Term] +id: GO:1900517 +name: positive regulation of xylose catabolic process to ethanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xylose catabolic process to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of xylose catabolic process to ethanol" NARROW [GOC:TermGenie] +synonym: "activation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "positive regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "up regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "up regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "upregulation of xylose catabolic process to ethanol" EXACT [GOC:TermGenie] +synonym: "upregulation of xylose catabolism to ethanol" EXACT [GOC:TermGenie] +is_a: GO:1900511 ! positive regulation of pentose catabolic process to ethanol +is_a: GO:1900515 ! regulation of xylose catabolic process to ethanol +relationship: positively_regulates GO:0044577 ! xylose catabolic process to ethanol + +[Term] +id: GO:1900518 +name: regulation of response to pullulan +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0044592 ! response to pullulan + +[Term] +id: GO:1900519 +name: negative regulation of response to pullulan +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to pullulan" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to pullulan" EXACT [GOC:TermGenie] +synonym: "downregulation of response to pullulan" EXACT [GOC:TermGenie] +synonym: "inhibition of response to pullulan" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900518 ! regulation of response to pullulan +relationship: negatively_regulates GO:0044592 ! response to pullulan + +[Term] +id: GO:1900520 +name: positive regulation of response to pullulan +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to pullulan." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to pullulan" NARROW [GOC:TermGenie] +synonym: "up regulation of response to pullulan" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to pullulan" EXACT [GOC:TermGenie] +synonym: "upregulation of response to pullulan" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900518 ! regulation of response to pullulan +relationship: positively_regulates GO:0044592 ! response to pullulan + +[Term] +id: GO:1900521 +name: regulation of response to amylopectin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0044591 ! response to amylopectin + +[Term] +id: GO:1900522 +name: negative regulation of response to amylopectin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to amylopectin" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to amylopectin" EXACT [GOC:TermGenie] +synonym: "downregulation of response to amylopectin" EXACT [GOC:TermGenie] +synonym: "inhibition of response to amylopectin" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900521 ! regulation of response to amylopectin +relationship: negatively_regulates GO:0044591 ! response to amylopectin + +[Term] +id: GO:1900523 +name: positive regulation of response to amylopectin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to amylopectin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to amylopectin" NARROW [GOC:TermGenie] +synonym: "up regulation of response to amylopectin" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to amylopectin" EXACT [GOC:TermGenie] +synonym: "upregulation of response to amylopectin" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900521 ! regulation of response to amylopectin +relationship: positively_regulates GO:0044591 ! response to amylopectin + +[Term] +id: GO:1900524 +name: obsolete positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of flocculation via cell wall protein-carbohydrate interaction process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252] +comment: This term was obsoleted because it represents a GO-CAM. +synonym: "activation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900525 +name: obsolete positive regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of phosphatidylserine biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324, PMID:8614637] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "activation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine anabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine biosynthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine biosynthetic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine formation by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine synthesis by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900526 +name: obsolete negative regulation of phosphatidylserine biosynthetic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylserine biosynthetic process by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, GOC:TermGenie, PMID:8056324] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of phosphatidylserine anabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine biosynthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine formation by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine synthesis by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900527 +name: obsolete regulation of nucleus size involved in G1 to G0 transition +namespace: biological_process +def: "OBSOLETE. Any regulation of nucleus size that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728] +comment: This term was made obsolete because it represents a phenotype. +synonym: "regulation of nuclear size involved in cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "regulation of nuclear size involved in establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear size involved in G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear size involved in G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear size involved in stationary phase" RELATED [GOC:TermGenie] +synonym: "regulation of nuclear volume involved in cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "regulation of nuclear volume involved in establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear volume involved in G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear volume involved in G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear volume involved in stationary phase" RELATED [GOC:TermGenie] +synonym: "regulation of nucleus size involved in cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "regulation of nucleus size involved in establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "regulation of nucleus size involved in G1 to G0 transition" EXACT [] +synonym: "regulation of nucleus size involved in G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of nucleus size involved in stationary phase" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900528 +name: obsolete regulation of cell shape involved in G1 to G0 transition +namespace: biological_process +def: "OBSOLETE. Any regulation of cell shape that is involved in G1 to G0 transition." [GOC:al, GOC:TermGenie, PMID:19366728] +comment: This term was made obsolete because it represents a phenotype. +synonym: "regulation of cell shape involved in cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "regulation of cell shape involved in establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape involved in G1 to G0 transition" EXACT [] +synonym: "regulation of cell shape involved in G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape involved in stationary phase" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900529 +name: obsolete regulation of cell shape involved in cellular response to glucose starvation +namespace: biological_process +def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to glucose starvation." [GOC:al, GOC:TermGenie, PMID:9135147] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of cell shape involved in cellular response to glucose starvation" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900530 +name: obsolete regulation of cell shape involved in cellular response to salt stress +namespace: biological_process +def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to salt stress." [GOC:al, GOC:TermGenie, PMID:9135147] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of cell shape involved in cellular response to salt stress" EXACT [] +synonym: "regulation of cell shape of cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape of cellular response to salt stress" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape of cellular salinity response" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900531 +name: obsolete regulation of cell shape involved in cellular response to heat +namespace: biological_process +def: "OBSOLETE. Any regulation of cell shape that is involved in cellular response to heat." [GOC:al, GOC:TermGenie, PMID:9135147] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of cell shape involved in cellular response to heat" EXACT [] +synonym: "regulation of cell shape of cellular response to heat" EXACT [GOC:TermGenie] +synonym: "regulation of cell shape of cellular response to heat stress" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900532 +name: obsolete negative regulation of cell proliferation involved in cellular hyperosmotic response +namespace: biological_process +def: "OBSOLETE. Negative regulation of cell proliferation during cellular hyperosmotic response." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] +synonym: "down regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] +synonym: "down regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] +synonym: "down regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] +synonym: "inhibition of cell proliferation of cellular HOG response" NARROW [GOC:TermGenie] +synonym: "inhibition of cell proliferation of cellular hyperosmotic response" NARROW [GOC:TermGenie] +synonym: "inhibition of cell proliferation of cellular hypertonic response" NARROW [GOC:TermGenie] +synonym: "inhibition of cell proliferation of cellular response to hypertonicity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell proliferation involved in cellular hyperosmotic response" EXACT [] +synonym: "negative regulation of cell proliferation of cellular HOG response" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell proliferation of cellular hyperosmotic response" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell proliferation of cellular hypertonic response" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell proliferation of cellular response to hypertonicity" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900533 +name: palmitic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving palmitic acid." [GOC:TermGenie] +is_a: GO:0001676 ! long-chain fatty acid metabolic process + +[Term] +id: GO:1900534 +name: palmitic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of palmitic acid." [GOC:TermGenie] +is_a: GO:0042758 ! long-chain fatty acid catabolic process +is_a: GO:1900533 ! palmitic acid metabolic process + +[Term] +id: GO:1900535 +name: palmitic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of palmitic acid." [GOC:TermGenie] +is_a: GO:0042759 ! long-chain fatty acid biosynthetic process +is_a: GO:1900533 ! palmitic acid metabolic process + +[Term] +id: GO:1900536 +name: obsolete regulation of glucose homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of glucose homeostasis" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900537 +name: obsolete negative regulation of glucose homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of glucose homeostasis" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose homeostasis" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose homeostasis" EXACT [GOC:TermGenie] +synonym: "inhibition of glucose homeostasis" NARROW [GOC:TermGenie] +synonym: "negative regulation of glucose homeostasis" EXACT [] +is_obsolete: true + +[Term] +id: GO:1900538 +name: obsolete positive regulation of glucose homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose homeostasis." [GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of glucose homeostasis" NARROW [GOC:TermGenie] +synonym: "positive regulation of glucose homeostasis" EXACT [] +synonym: "up regulation of glucose homeostasis" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose homeostasis" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose homeostasis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900539 +name: fumonisin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumonisin." [GOC:TermGenie] +synonym: "fumonisin metabolism" RELATED [] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:1900540 +name: fumonisin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumonisin." [GOC:TermGenie] +synonym: "fumonisin breakdown" EXACT [] +synonym: "fumonisin catabolism" EXACT [] +synonym: "fumonisin degradation" RELATED [] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900539 ! fumonisin metabolic process + +[Term] +id: GO:1900541 +name: fumonisin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumonisin." [GOC:TermGenie] +synonym: "fumonisin anabolism" EXACT [] +synonym: "fumonisin biosynthesis" EXACT [] +synonym: "fumonisin formation" EXACT [] +synonym: "fumonisin synthesis" EXACT [] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900539 ! fumonisin metabolic process + +[Term] +id: GO:1900542 +name: regulation of purine nucleotide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] +synonym: "regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006140 ! regulation of nucleotide metabolic process +relationship: regulates GO:0006163 ! purine nucleotide metabolic process + +[Term] +id: GO:1900543 +name: negative regulation of purine nucleotide metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] +synonym: "down regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "down regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "down regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "downregulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "downregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of purine metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of purine nucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of purine nucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045980 ! negative regulation of nucleotide metabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +relationship: negatively_regulates GO:0006163 ! purine nucleotide metabolic process + +[Term] +id: GO:1900544 +name: positive regulation of purine nucleotide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process." [GOC:TermGenie] +synonym: "activation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "activation of purine nucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of purine nucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "up regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "up regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of purine metabolic process" NARROW [GOC:TermGenie] +synonym: "upregulation of purine metabolism" NARROW [GOC:TermGenie] +synonym: "upregulation of purine nucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of purine nucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045981 ! positive regulation of nucleotide metabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +relationship: positively_regulates GO:0006163 ! purine nucleotide metabolic process + +[Term] +id: GO:1900545 +name: obsolete regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of phenotypic switching." [GOC:di, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900546 +name: obsolete positive regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of phenotypic switching." [GOC:di, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "activation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up-regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "upregulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900547 +name: obsolete negative regulation of phenotypic switching by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of phenotypic switching." [GOC:di, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of phenotypic dimorphism by regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900548 +name: heme B catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:TermGenie, GOC:yaf, PMID:28352909, UniPathway:UPA00684] +synonym: "heme B breakdown" EXACT [GOC:TermGenie] +synonym: "heme B catabolism" EXACT [GOC:TermGenie] +synonym: "heme B degradation" EXACT [GOC:TermGenie] +synonym: "protoheme catabolic process" EXACT [] +synonym: "protoheme degradation" EXACT [] +xref: MetaCyc:PWY-5874 +is_a: GO:0042167 ! heme catabolic process +is_a: GO:0046492 ! heme B metabolic process + +[Term] +id: GO:1900549 +name: N',N'',N'''-triacetylfusarinine C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1900550 +name: N',N'',N'''-triacetylfusarinine C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C breakdown" EXACT [GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C catabolism" EXACT [GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C degradation" EXACT [GOC:TermGenie] +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:1900551 +name: N',N'',N'''-triacetylfusarinine C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C." [GOC:di, GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900549 ! N',N'',N'''-triacetylfusarinine C metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:1900552 +name: asperfuranone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving asperfuranone." [GOC:di, GOC:TermGenie] +synonym: "asperfuranone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:1900553 +name: asperfuranone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of asperfuranone." [GOC:di, GOC:TermGenie] +synonym: "asperfuranone breakdown" EXACT [GOC:TermGenie] +synonym: "asperfuranone catabolism" EXACT [GOC:TermGenie] +synonym: "asperfuranone degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900552 ! asperfuranone metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900554 +name: asperfuranone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of asperfuranone." [GOC:di, GOC:TermGenie] +synonym: "asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "asperfuranone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1900552 ! asperfuranone metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:1900555 +name: emericellamide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving emericellamide." [GOC:di, GOC:TermGenie] +synonym: "emericellamide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0050761 ! depsipeptide metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:1900556 +name: emericellamide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of emericellamide." [GOC:di, GOC:TermGenie] +synonym: "emericellamide breakdown" EXACT [GOC:TermGenie] +synonym: "emericellamide catabolism" EXACT [GOC:TermGenie] +synonym: "emericellamide degradation" EXACT [GOC:TermGenie] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0050762 ! depsipeptide catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900555 ! emericellamide metabolic process +is_a: GO:1901335 ! lactone catabolic process + +[Term] +id: GO:1900557 +name: emericellamide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of emericellamide." [GOC:di, GOC:TermGenie] +synonym: "emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "emericellamide formation" EXACT [GOC:TermGenie] +synonym: "emericellamide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0050763 ! depsipeptide biosynthetic process +is_a: GO:1900555 ! emericellamide metabolic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:1900558 +name: austinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving austinol." [GOC:di, GOC:TermGenie] +synonym: "austinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1900559 +name: austinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of austinol." [GOC:di, GOC:TermGenie] +synonym: "austinol breakdown" EXACT [GOC:TermGenie] +synonym: "austinol catabolism" EXACT [GOC:TermGenie] +synonym: "austinol degradation" EXACT [GOC:TermGenie] +is_a: GO:1900558 ! austinol metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1900560 +name: austinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of austinol." [GOC:di, GOC:TermGenie] +synonym: "austinol anabolism" EXACT [GOC:TermGenie] +synonym: "austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "austinol formation" EXACT [GOC:TermGenie] +synonym: "austinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900558 ! austinol metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1900561 +name: dehydroaustinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving dehydroaustinol." [GOC:di, GOC:TermGenie] +synonym: "dehydroaustinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1900562 +name: dehydroaustinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dehydroaustinol." [GOC:di, GOC:TermGenie] +synonym: "dehydroaustinol breakdown" EXACT [GOC:TermGenie] +synonym: "dehydroaustinol catabolism" EXACT [GOC:TermGenie] +synonym: "dehydroaustinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900561 ! dehydroaustinol metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1900563 +name: dehydroaustinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of dehydroaustinol." [GOC:di, GOC:TermGenie] +synonym: "dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "dehydroaustinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900561 ! dehydroaustinol metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1900564 +name: chanoclavine-I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chanoclavine-I." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I metabolism" EXACT [GOC:TermGenie] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0035836 ! ergot alkaloid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900565 +name: chanoclavine-I catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I breakdown" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I catabolism" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I degradation" EXACT [GOC:TermGenie] +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900564 ! chanoclavine-I metabolic process +is_a: GO:1900806 ! ergot alkaloid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900566 +name: chanoclavine-I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0035837 ! ergot alkaloid biosynthetic process +is_a: GO:1900564 ! chanoclavine-I metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900567 +name: chanoclavine-I aldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I aldehyde metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0035836 ! ergot alkaloid metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900568 +name: chanoclavine-I aldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I aldehyde breakdown" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I aldehyde catabolism" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I aldehyde degradation" EXACT [GOC:TermGenie] +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process +is_a: GO:1900806 ! ergot alkaloid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900569 +name: chanoclavine-I aldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde." [GOC:di, GOC:TermGenie] +synonym: "chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +is_a: GO:0035837 ! ergot alkaloid biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1900567 ! chanoclavine-I aldehyde metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900570 +name: diorcinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diorcinol." [GOC:di, GOC:TermGenie] +synonym: "diorcinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:1900571 +name: diorcinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diorcinol." [GOC:di, GOC:TermGenie] +synonym: "diorcinol breakdown" EXACT [GOC:TermGenie] +synonym: "diorcinol catabolism" EXACT [GOC:TermGenie] +synonym: "diorcinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900570 ! diorcinol metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900572 +name: diorcinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of diorcinol." [GOC:di, GOC:TermGenie] +synonym: "diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "diorcinol formation" EXACT [GOC:TermGenie] +synonym: "diorcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900570 ! diorcinol metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900573 +name: emodin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving emodin." [GOC:di, GOC:TermGenie] +synonym: "emodin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1900574 +name: emodin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of emodin." [GOC:di, GOC:TermGenie] +synonym: "emodin breakdown" EXACT [GOC:TermGenie] +synonym: "emodin catabolism" EXACT [GOC:TermGenie] +synonym: "emodin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900573 ! emodin metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1900575 +name: emodin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of emodin." [GOC:di, GOC:TermGenie] +synonym: "emodin anabolism" EXACT [GOC:TermGenie] +synonym: "emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "emodin formation" EXACT [GOC:TermGenie] +synonym: "emodin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900573 ! emodin metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1900576 +name: gerfelin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gerfelin." [GOC:di, GOC:TermGenie] +synonym: "gerfelin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1900577 +name: gerfelin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gerfelin." [GOC:di, GOC:TermGenie] +synonym: "gerfelin breakdown" EXACT [GOC:TermGenie] +synonym: "gerfelin catabolism" EXACT [GOC:TermGenie] +synonym: "gerfelin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900576 ! gerfelin metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900578 +name: gerfelin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gerfelin." [GOC:di, GOC:TermGenie] +synonym: "gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "gerfelin formation" EXACT [GOC:TermGenie] +synonym: "gerfelin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900576 ! gerfelin metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900579 +name: (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:1900580 +name: (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol breakdown" EXACT [GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol catabolism" EXACT [GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol degradation" EXACT [GOC:TermGenie] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016105 ! triterpenoid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process + +[Term] +id: GO:1900581 +name: (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol." [GOC:di, GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol anabolism" EXACT [GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol formation" EXACT [GOC:TermGenie] +synonym: "(17Z)-protosta-17(20),24-dien-3beta-ol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0010686 ! tetracyclic triterpenoid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900579 ! (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:1900582 +name: o-orsellinic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving o-orsellinic acid." [GOC:di, GOC:TermGenie] +synonym: "o-orsellinic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1900583 +name: o-orsellinic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid." [GOC:di, GOC:TermGenie] +synonym: "o-orsellinic acid breakdown" EXACT [GOC:TermGenie] +synonym: "o-orsellinic acid catabolism" EXACT [GOC:TermGenie] +synonym: "o-orsellinic acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900582 ! o-orsellinic acid metabolic process + +[Term] +id: GO:1900584 +name: o-orsellinic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of o-orsellinic acid." [GOC:di, GOC:TermGenie] +synonym: "o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1900582 ! o-orsellinic acid metabolic process + +[Term] +id: GO:1900585 +name: arugosin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving arugosin." [GOC:di, GOC:TermGenie] +synonym: "arugosin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1900586 +name: arugosin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of arugosin." [GOC:di, GOC:TermGenie] +synonym: "arugosin breakdown" EXACT [GOC:TermGenie] +synonym: "arugosin catabolism" EXACT [GOC:TermGenie] +synonym: "arugosin degradation" EXACT [GOC:TermGenie] +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900585 ! arugosin metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1900587 +name: arugosin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of arugosin." [GOC:di, GOC:TermGenie] +synonym: "arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "arugosin formation" EXACT [GOC:TermGenie] +synonym: "arugosin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900585 ! arugosin metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1900588 +name: violaceol I metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving violaceol I." [GOC:di, GOC:TermGenie] +synonym: "violaceol I metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:1900589 +name: violaceol I catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of violaceol I." [GOC:di, GOC:TermGenie] +synonym: "violaceol I breakdown" EXACT [GOC:TermGenie] +synonym: "violaceol I catabolism" EXACT [GOC:TermGenie] +synonym: "violaceol I degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900588 ! violaceol I metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900590 +name: violaceol I biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of violaceol I." [GOC:di, GOC:TermGenie] +synonym: "violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "violaceol I formation" EXACT [GOC:TermGenie] +synonym: "violaceol I synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900588 ! violaceol I metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900591 +name: violaceol II metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving violaceol II." [GOC:di, GOC:TermGenie] +synonym: "violaceol II metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:1900592 +name: violaceol II catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of violaceol II." [GOC:di, GOC:TermGenie] +synonym: "violaceol II breakdown" EXACT [GOC:TermGenie] +synonym: "violaceol II catabolism" EXACT [GOC:TermGenie] +synonym: "violaceol II degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900591 ! violaceol II metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900593 +name: violaceol II biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of violaceol II." [GOC:di, GOC:TermGenie] +synonym: "violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "violaceol II formation" EXACT [GOC:TermGenie] +synonym: "violaceol II synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900591 ! violaceol II metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900594 +name: (+)-kotanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-kotanin." [GOC:di, GOC:TermGenie] +synonym: "(+)-kotanin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900595 +name: (+)-kotanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-kotanin." [GOC:di, GOC:TermGenie] +synonym: "(+)-kotanin breakdown" EXACT [GOC:TermGenie] +synonym: "(+)-kotanin catabolism" EXACT [GOC:TermGenie] +synonym: "(+)-kotanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900594 ! (+)-kotanin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900596 +name: (+)-kotanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-kotanin." [GOC:di, GOC:TermGenie] +synonym: "(+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "(+)-kotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900594 ! (+)-kotanin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900597 +name: demethylkotanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving demethylkotanin." [GOC:di, GOC:TermGenie] +synonym: "demethylkotanin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900598 +name: demethylkotanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of demethylkotanin." [GOC:di, GOC:TermGenie] +synonym: "demethylkotanin breakdown" EXACT [GOC:TermGenie] +synonym: "demethylkotanin catabolism" EXACT [GOC:TermGenie] +synonym: "demethylkotanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900597 ! demethylkotanin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900599 +name: demethylkotanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of demethylkotanin." [GOC:di, GOC:TermGenie] +synonym: "demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "demethylkotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900597 ! demethylkotanin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900600 +name: endocrocin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving endocrocin." [GOC:di, GOC:TermGenie] +synonym: "endocrocin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1900601 +name: endocrocin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of endocrocin." [GOC:di, GOC:TermGenie] +synonym: "endocrocin breakdown" EXACT [GOC:TermGenie] +synonym: "endocrocin catabolism" EXACT [GOC:TermGenie] +synonym: "endocrocin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900600 ! endocrocin metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1900602 +name: endocrocin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of endocrocin." [GOC:di, GOC:TermGenie] +synonym: "endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "endocrocin formation" EXACT [GOC:TermGenie] +synonym: "endocrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900600 ! endocrocin metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1900603 +name: tensidol A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tensidol A." [GOC:di, GOC:TermGenie] +synonym: "tensidol A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1900604 +name: tensidol A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tensidol A." [GOC:di, GOC:TermGenie] +synonym: "tensidol A breakdown" EXACT [GOC:TermGenie] +synonym: "tensidol A catabolism" EXACT [GOC:TermGenie] +synonym: "tensidol A degradation" EXACT [GOC:TermGenie] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900603 ! tensidol A metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:1900605 +name: tensidol A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tensidol A." [GOC:di, GOC:TermGenie] +synonym: "tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "tensidol A formation" EXACT [GOC:TermGenie] +synonym: "tensidol A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900603 ! tensidol A metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:1900606 +name: tensidol B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tensidol B." [GOC:di, GOC:TermGenie] +synonym: "tensidol B metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900607 +name: tensidol B catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tensidol B." [GOC:di, GOC:TermGenie] +synonym: "tensidol B breakdown" EXACT [GOC:TermGenie] +synonym: "tensidol B catabolism" EXACT [GOC:TermGenie] +synonym: "tensidol B degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900606 ! tensidol B metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900608 +name: tensidol B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tensidol B." [GOC:di, GOC:TermGenie] +synonym: "tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "tensidol B formation" EXACT [GOC:TermGenie] +synonym: "tensidol B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900606 ! tensidol B metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900609 +name: F-9775A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving F-9775A." [GOC:di, GOC:TermGenie] +synonym: "F-9775A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:1900610 +name: F-9775A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of F-9775A." [GOC:di, GOC:TermGenie] +synonym: "F-9775A breakdown" EXACT [GOC:TermGenie] +synonym: "F-9775A catabolism" EXACT [GOC:TermGenie] +synonym: "F-9775A degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:1900609 ! F-9775A metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:1900611 +name: F-9775A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of F-9775A." [GOC:di, GOC:TermGenie] +synonym: "F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "F-9775A formation" EXACT [GOC:TermGenie] +synonym: "F-9775A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900609 ! F-9775A metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:1900612 +name: F-9775B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving F-9775B." [GOC:di, GOC:TermGenie] +synonym: "F-9775B metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:1900613 +name: F-9775B catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of F-9775B." [GOC:di, GOC:TermGenie] +synonym: "F-9775B breakdown" EXACT [GOC:TermGenie] +synonym: "F-9775B catabolism" EXACT [GOC:TermGenie] +synonym: "F-9775B degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:1900612 ! F-9775B metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:1900614 +name: F-9775B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of F-9775B." [GOC:di, GOC:TermGenie] +synonym: "F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "F-9775B formation" EXACT [GOC:TermGenie] +synonym: "F-9775B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900612 ! F-9775B metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:1900615 +name: emericellamide A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving emericellamide A." [GOC:di, GOC:TermGenie] +synonym: "emericellamide A metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900555 ! emericellamide metabolic process + +[Term] +id: GO:1900616 +name: emericellamide A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of emericellamide A." [GOC:di, GOC:TermGenie] +synonym: "emericellamide A breakdown" EXACT [GOC:TermGenie] +synonym: "emericellamide A catabolism" EXACT [GOC:TermGenie] +synonym: "emericellamide A degradation" EXACT [GOC:TermGenie] +is_a: GO:1900556 ! emericellamide catabolic process +is_a: GO:1900615 ! emericellamide A metabolic process + +[Term] +id: GO:1900617 +name: emericellamide A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of emericellamide A." [GOC:di, GOC:TermGenie] +synonym: "emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "emericellamide A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900557 ! emericellamide biosynthetic process +is_a: GO:1900615 ! emericellamide A metabolic process + +[Term] +id: GO:1900618 +name: regulation of shoot system morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shoot morphogenesis." [GOC:TermGenie] +synonym: "regulation of shoot morphogenesis" EXACT [] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0010016 ! shoot system morphogenesis + +[Term] +id: GO:1900619 +name: acetate ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie] +synonym: "acetate ester metabolism" EXACT [GOC:TermGenie] +synonym: "acetyl ester metabolic process" EXACT [CHEBI:47622] +synonym: "acetyl ester metabolism" EXACT [CHEBI:47622] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1900620 +name: acetate ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid." [GOC:TermGenie, PMID:15042596] +synonym: "acetate ester anabolism" EXACT [GOC:TermGenie] +synonym: "acetate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "acetate ester formation" EXACT [GOC:TermGenie] +synonym: "acetate ester synthesis" EXACT [GOC:TermGenie] +synonym: "acetyl ester biosynthesis" EXACT [CHEBI:47622] +synonym: "acetyl ester biosynthetic process" EXACT [CHEBI:47622] +is_a: GO:1900619 ! acetate ester metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1900621 +name: obsolete regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +namespace: biological_process +def: "OBSOLETE. Calcium-mediated signaling that results in regulation of transcription from an RNA polymerase II promoter." [GOC:BHF, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0006357 +consider: GO:0019722 + +[Term] +id: GO:1900622 +name: positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling +namespace: biological_process +def: "Calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter." [GOC:bf, GOC:BHF, GOC:dgf, GOC:TermGenie, PMID:9407035, PMID:9407036] +synonym: "activation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "calcineurin-dependent transcription activation" NARROW [PMID:9407036] +synonym: "calcineurin-dependent transcriptional induction" NARROW [PMID:9407035] +synonym: "calcineurin-mediated activation of transcription" NARROW [PMID:9407035] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter by calcium-mediated signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter by calcium-mediated signaling" EXACT [GOC:TermGenie] +is_a: GO:0019722 ! calcium-mediated signaling +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II + +[Term] +id: GO:1900623 +name: regulation of monocyte aggregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: regulates GO:0070487 ! monocyte aggregation + +[Term] +id: GO:1900624 +name: negative regulation of monocyte aggregation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "down regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "downregulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "downregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "inhibition of monocyte aggregation" NARROW [GOC:TermGenie] +synonym: "inhibition of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "negative regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +is_a: GO:1900623 ! regulation of monocyte aggregation +is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion +relationship: negatively_regulates GO:0070487 ! monocyte aggregation + +[Term] +id: GO:1900625 +name: positive regulation of monocyte aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monocyte aggregation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of monocyte aggregation" NARROW [GOC:TermGenie] +synonym: "activation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "positive regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "up regulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "up regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +synonym: "upregulation of monocyte aggregation" EXACT [GOC:TermGenie] +synonym: "upregulation of mononuclear phagocyte aggregation" EXACT [GOC:TermGenie] +is_a: GO:1900623 ! regulation of monocyte aggregation +is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion +relationship: positively_regulates GO:0070487 ! monocyte aggregation + +[Term] +id: GO:1900626 +name: regulation of arugosin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "regulation of arugosin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900587 ! arugosin biosynthetic process + +[Term] +id: GO:1900627 +name: negative regulation of arugosin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of arugosin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of arugosin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of arugosin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900626 ! regulation of arugosin biosynthetic process +relationship: negatively_regulates GO:1900587 ! arugosin biosynthetic process + +[Term] +id: GO:1900628 +name: positive regulation of arugosin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of arugosin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of arugosin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "activation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of arugosin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arugosin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of arugosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arugosin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of arugosin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of arugosin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900626 ! regulation of arugosin biosynthetic process +relationship: positively_regulates GO:1900587 ! arugosin biosynthetic process + +[Term] +id: GO:1900629 +name: methanophenazine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving methanophenazine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "methanophenazine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1900630 +name: methanophenazine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methanophenazine." [GOC:mengo_curators, GOC:TermGenie] +synonym: "methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "methanophenazine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1900629 ! methanophenazine metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:1900631 +name: tridecane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tridecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "tridecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:1900632 +name: tridecane biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tridecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "tridecane formation" EXACT [GOC:TermGenie] +synonym: "tridecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043447 ! alkane biosynthetic process +is_a: GO:1900631 ! tridecane metabolic process + +[Term] +id: GO:1900633 +name: pentadecane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentadecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "pentadecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:1900634 +name: pentadecane biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentadecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "pentadecane anabolism" EXACT [GOC:TermGenie] +synonym: "pentadecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "pentadecane formation" EXACT [GOC:TermGenie] +synonym: "pentadecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043447 ! alkane biosynthetic process +is_a: GO:1900633 ! pentadecane metabolic process + +[Term] +id: GO:1900635 +name: heptadecane metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heptadecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "heptadecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043446 ! cellular alkane metabolic process + +[Term] +id: GO:1900636 +name: heptadecane biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heptadecane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "heptadecane anabolism" EXACT [GOC:TermGenie] +synonym: "heptadecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "heptadecane formation" EXACT [GOC:TermGenie] +synonym: "heptadecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043447 ! alkane biosynthetic process +is_a: GO:1900635 ! heptadecane metabolic process + +[Term] +id: GO:1900637 +name: regulation of asperfuranone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:1900554 ! asperfuranone biosynthetic process + +[Term] +id: GO:1900638 +name: negative regulation of asperfuranone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "down regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "downregulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of asperfuranone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "inhibition of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process +is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:1900554 ! asperfuranone biosynthetic process + +[Term] +id: GO:1900639 +name: positive regulation of asperfuranone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asperfuranone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "activation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of asperfuranone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "activation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "up regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of asperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of asperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of asperfuranone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of asperfuranone formation" EXACT [GOC:TermGenie] +synonym: "upregulation of asperfuranone synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900637 ! regulation of asperfuranone biosynthetic process +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:1900554 ! asperfuranone biosynthetic process + +[Term] +id: GO:1900640 +name: regulation of austinol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "regulation of austinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009889 ! regulation of biosynthetic process +relationship: regulates GO:1900560 ! austinol biosynthetic process + +[Term] +id: GO:1900641 +name: negative regulation of austinol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of austinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of austinol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of austinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:1900640 ! regulation of austinol biosynthetic process +relationship: negatively_regulates GO:1900560 ! austinol biosynthetic process + +[Term] +id: GO:1900642 +name: positive regulation of austinol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of austinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of austinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of austinol formation" EXACT [GOC:TermGenie] +synonym: "activation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of austinol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of austinol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of austinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of austinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of austinol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of austinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:1900640 ! regulation of austinol biosynthetic process +relationship: positively_regulates GO:1900560 ! austinol biosynthetic process + +[Term] +id: GO:1900643 +name: regulation of chanoclavine-I biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:1900566 ! chanoclavine-I biosynthetic process + +[Term] +id: GO:1900644 +name: negative regulation of chanoclavine-I biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process +is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:1900566 ! chanoclavine-I biosynthetic process + +[Term] +id: GO:1900645 +name: positive regulation of chanoclavine-I biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I formation" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900643 ! regulation of chanoclavine-I biosynthetic process +is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:1900566 ! chanoclavine-I biosynthetic process + +[Term] +id: GO:1900646 +name: regulation of chanoclavine-I aldehyde biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process +relationship: regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process + +[Term] +id: GO:1900647 +name: negative regulation of chanoclavine-I aldehyde biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "down regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "downregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "inhibition of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process +is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process +relationship: negatively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process + +[Term] +id: GO:1900648 +name: positive regulation of chanoclavine-I aldehyde biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I aldehyde biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "activation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "up regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I aldehyde biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I aldehyde formation" EXACT [GOC:TermGenie] +synonym: "upregulation of chanoclavine-I aldehyde synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900646 ! regulation of chanoclavine-I aldehyde biosynthetic process +is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process +relationship: positively_regulates GO:1900569 ! chanoclavine-I aldehyde biosynthetic process + +[Term] +id: GO:1900649 +name: regulation of dehydroaustinol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900563 ! dehydroaustinol biosynthetic process + +[Term] +id: GO:1900650 +name: negative regulation of dehydroaustinol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process +relationship: negatively_regulates GO:1900563 ! dehydroaustinol biosynthetic process + +[Term] +id: GO:1900651 +name: positive regulation of dehydroaustinol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dehydroaustinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of dehydroaustinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "activation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of dehydroaustinol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of dehydroaustinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of dehydroaustinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of dehydroaustinol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of dehydroaustinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900649 ! regulation of dehydroaustinol biosynthetic process +relationship: positively_regulates GO:1900563 ! dehydroaustinol biosynthetic process + +[Term] +id: GO:1900652 +name: regulation of demethylkotanin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900599 ! demethylkotanin biosynthetic process + +[Term] +id: GO:1900653 +name: negative regulation of demethylkotanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process +relationship: negatively_regulates GO:1900599 ! demethylkotanin biosynthetic process + +[Term] +id: GO:1900654 +name: positive regulation of demethylkotanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of demethylkotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of demethylkotanin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "activation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of demethylkotanin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of demethylkotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of demethylkotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of demethylkotanin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of demethylkotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900652 ! regulation of demethylkotanin biosynthetic process +relationship: positively_regulates GO:1900599 ! demethylkotanin biosynthetic process + +[Term] +id: GO:1900655 +name: regulation of diorcinol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900572 ! diorcinol biosynthetic process + +[Term] +id: GO:1900656 +name: negative regulation of diorcinol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of diorcinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900655 ! regulation of diorcinol biosynthetic process +relationship: negatively_regulates GO:1900572 ! diorcinol biosynthetic process + +[Term] +id: GO:1900657 +name: positive regulation of diorcinol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of diorcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of diorcinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "activation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of diorcinol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of diorcinol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of diorcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of diorcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of diorcinol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of diorcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900655 ! regulation of diorcinol biosynthetic process +relationship: positively_regulates GO:1900572 ! diorcinol biosynthetic process + +[Term] +id: GO:1900658 +name: regulation of emericellamide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900557 ! emericellamide biosynthetic process + +[Term] +id: GO:1900659 +name: negative regulation of emericellamide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900658 ! regulation of emericellamide biosynthetic process +relationship: negatively_regulates GO:1900557 ! emericellamide biosynthetic process + +[Term] +id: GO:1900660 +name: positive regulation of emericellamide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of emericellamide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide formation" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900658 ! regulation of emericellamide biosynthetic process +relationship: positively_regulates GO:1900557 ! emericellamide biosynthetic process + +[Term] +id: GO:1900661 +name: regulation of emericellamide A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900658 ! regulation of emericellamide biosynthetic process +relationship: regulates GO:1900617 ! emericellamide A biosynthetic process + +[Term] +id: GO:1900662 +name: negative regulation of emericellamide A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "down regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "inhibition of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900659 ! negative regulation of emericellamide biosynthetic process +is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process +relationship: negatively_regulates GO:1900617 ! emericellamide A biosynthetic process + +[Term] +id: GO:1900663 +name: positive regulation of emericellamide A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of emericellamide A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "activation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "up regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide A anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide A biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide A formation" EXACT [GOC:TermGenie] +synonym: "upregulation of emericellamide A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900660 ! positive regulation of emericellamide biosynthetic process +is_a: GO:1900661 ! regulation of emericellamide A biosynthetic process +relationship: positively_regulates GO:1900617 ! emericellamide A biosynthetic process + +[Term] +id: GO:1900664 +name: regulation of emodin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "regulation of emodin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900575 ! emodin biosynthetic process + +[Term] +id: GO:1900665 +name: negative regulation of emodin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of emodin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of emodin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of emodin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900664 ! regulation of emodin biosynthetic process +relationship: negatively_regulates GO:1900575 ! emodin biosynthetic process + +[Term] +id: GO:1900666 +name: positive regulation of emodin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of emodin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of emodin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of emodin formation" EXACT [GOC:TermGenie] +synonym: "activation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of emodin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emodin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of emodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of emodin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of emodin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of emodin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900664 ! regulation of emodin biosynthetic process +relationship: positively_regulates GO:1900575 ! emodin biosynthetic process + +[Term] +id: GO:1900667 +name: regulation of endocrocin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900602 ! endocrocin biosynthetic process + +[Term] +id: GO:1900668 +name: negative regulation of endocrocin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of endocrocin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900667 ! regulation of endocrocin biosynthetic process +relationship: negatively_regulates GO:1900602 ! endocrocin biosynthetic process + +[Term] +id: GO:1900669 +name: positive regulation of endocrocin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of endocrocin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "activation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endocrocin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of endocrocin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of endocrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of endocrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of endocrocin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of endocrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900667 ! regulation of endocrocin biosynthetic process +relationship: positively_regulates GO:1900602 ! endocrocin biosynthetic process + +[Term] +id: GO:1900670 +name: regulation of F-9775A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +relationship: regulates GO:1900611 ! F-9775A biosynthetic process + +[Term] +id: GO:1900671 +name: negative regulation of F-9775A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900670 ! regulation of F-9775A biosynthetic process +is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process +relationship: negatively_regulates GO:1900611 ! F-9775A biosynthetic process + +[Term] +id: GO:1900672 +name: positive regulation of F-9775A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of F-9775A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "activation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of F-9775A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "activation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775A synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775A anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775A biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775A formation" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900670 ! regulation of F-9775A biosynthetic process +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +relationship: positively_regulates GO:1900611 ! F-9775A biosynthetic process + +[Term] +id: GO:1900673 +name: olefin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving olefin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "olefin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0120252 ! hydrocarbon metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:1900674 +name: olefin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of olefin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "olefin anabolism" EXACT [GOC:TermGenie] +synonym: "olefin biosynthesis" EXACT [GOC:TermGenie] +synonym: "olefin formation" EXACT [GOC:TermGenie] +synonym: "olefin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0120251 ! hydrocarbon biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1900673 ! olefin metabolic process + +[Term] +id: GO:1900675 +name: regulation of F-9775B biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +relationship: regulates GO:1900614 ! F-9775B biosynthetic process + +[Term] +id: GO:1900676 +name: negative regulation of F-9775B biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "down regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "downregulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775B biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "inhibition of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900675 ! regulation of F-9775B biosynthetic process +is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process +relationship: negatively_regulates GO:1900614 ! F-9775B biosynthetic process + +[Term] +id: GO:1900677 +name: positive regulation of F-9775B biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of F-9775B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "activation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of F-9775B biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "activation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "up regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-9775B synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775B anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775B biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775B formation" EXACT [GOC:TermGenie] +synonym: "upregulation of F-9775B synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900675 ! regulation of F-9775B biosynthetic process +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +relationship: positively_regulates GO:1900614 ! F-9775B biosynthetic process + +[Term] +id: GO:1900678 +name: regulation of ferricrocin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process +relationship: regulates GO:0031171 ! ferricrocin biosynthetic process + +[Term] +id: GO:1900679 +name: negative regulation of ferricrocin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "downregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "downregulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ferricrocin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "inhibition of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process +is_a: GO:1905569 ! negative regulation of ferrichrome biosynthetic process +relationship: negatively_regulates GO:0031171 ! ferricrocin biosynthetic process + +[Term] +id: GO:1900680 +name: positive regulation of ferricrocin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ferricrocin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of ferricrocin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "activation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "activation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "activation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ferricrocin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ferricrocin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ferricrocin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ferricrocin biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "upregulation of ferricrocin biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "upregulation of ferricrocin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ferricrocin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900678 ! regulation of ferricrocin biosynthetic process +is_a: GO:1905570 ! positive regulation of ferrichrome biosynthetic process +relationship: positively_regulates GO:0031171 ! ferricrocin biosynthetic process + +[Term] +id: GO:1900681 +name: octadecene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving octadecene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "octadecene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900682 +name: octadecene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of octadecene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "1-octadecene biosynthetic process" EXACT [GOC:mengo_curators] +synonym: "octadecene anabolism" EXACT [GOC:TermGenie] +synonym: "octadecene biosynthesis" EXACT [GOC:TermGenie] +synonym: "octadecene formation" EXACT [GOC:TermGenie] +synonym: "octadecene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900681 ! octadecene metabolic process + +[Term] +id: GO:1900683 +name: regulation of fumonisin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900541 ! fumonisin biosynthetic process + +[Term] +id: GO:1900684 +name: negative regulation of fumonisin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of fumonisin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900683 ! regulation of fumonisin biosynthetic process +relationship: negatively_regulates GO:1900541 ! fumonisin biosynthetic process + +[Term] +id: GO:1900685 +name: positive regulation of fumonisin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fumonisin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of fumonisin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "activation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumonisin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of fumonisin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of fumonisin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of fumonisin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of fumonisin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of fumonisin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900683 ! regulation of fumonisin biosynthetic process +relationship: positively_regulates GO:1900541 ! fumonisin biosynthetic process + +[Term] +id: GO:1900686 +name: regulation of gerfelin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900578 ! gerfelin biosynthetic process + +[Term] +id: GO:1900687 +name: negative regulation of gerfelin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of gerfelin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900686 ! regulation of gerfelin biosynthetic process +relationship: negatively_regulates GO:1900578 ! gerfelin biosynthetic process + +[Term] +id: GO:1900688 +name: positive regulation of gerfelin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gerfelin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of gerfelin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "activation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of gerfelin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gerfelin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of gerfelin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gerfelin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of gerfelin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of gerfelin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900686 ! regulation of gerfelin biosynthetic process +relationship: positively_regulates GO:1900578 ! gerfelin biosynthetic process + +[Term] +id: GO:1900689 +name: regulation of gliotoxin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:2001310 ! gliotoxin biosynthetic process + +[Term] +id: GO:1900690 +name: negative regulation of gliotoxin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of gliotoxin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process +relationship: negatively_regulates GO:2001310 ! gliotoxin biosynthetic process + +[Term] +id: GO:1900691 +name: positive regulation of gliotoxin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gliotoxin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of gliotoxin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "activation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gliotoxin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of gliotoxin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gliotoxin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of gliotoxin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of gliotoxin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900689 ! regulation of gliotoxin biosynthetic process +relationship: positively_regulates GO:2001310 ! gliotoxin biosynthetic process + +[Term] +id: GO:1900692 +name: regulation of (+)-kotanin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900596 ! (+)-kotanin biosynthetic process + +[Term] +id: GO:1900693 +name: negative regulation of (+)-kotanin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process +relationship: negatively_regulates GO:1900596 ! (+)-kotanin biosynthetic process + +[Term] +id: GO:1900694 +name: positive regulation of (+)-kotanin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of (+)-kotanin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of (+)-kotanin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "activation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of (+)-kotanin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of (+)-kotanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of (+)-kotanin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of (+)-kotanin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of (+)-kotanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900692 ! regulation of (+)-kotanin biosynthetic process +relationship: positively_regulates GO:1900596 ! (+)-kotanin biosynthetic process + +[Term] +id: GO:1900695 +name: regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process + +[Term] +id: GO:1900696 +name: negative regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "down regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "downregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "inhibition of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process +relationship: negatively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process + +[Term] +id: GO:1900697 +name: positive regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of N',N'',N'''-triacetylfusarinine C biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "activation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "up regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of N',N'',N'''-triacetylfusarinine C anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of N',N'',N'''-triacetylfusarinine C formation" EXACT [GOC:TermGenie] +synonym: "upregulation of N',N'',N'''-triacetylfusarinine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900695 ! regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process +relationship: positively_regulates GO:1900551 ! N',N'',N'''-triacetylfusarinine C biosynthetic process + +[Term] +id: GO:1900698 +name: regulation of o-orsellinic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900584 ! o-orsellinic acid biosynthetic process + +[Term] +id: GO:1900699 +name: negative regulation of o-orsellinic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "inhibition of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process +relationship: negatively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process + +[Term] +id: GO:1900700 +name: positive regulation of o-orsellinic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of o-orsellinic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "activation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of o-orsellinic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "activation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of o-orsellinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of o-orsellinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of o-orsellinic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of o-orsellinic acid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of o-orsellinic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900698 ! regulation of o-orsellinic acid biosynthetic process +relationship: positively_regulates GO:1900584 ! o-orsellinic acid biosynthetic process + +[Term] +id: GO:1900701 +name: regulation of orcinol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "regulation of orcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0046197 ! orcinol biosynthetic process + +[Term] +id: GO:1900702 +name: negative regulation of orcinol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of orcinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of orcinol formation" EXACT [GOC:TermGenie] +synonym: "inhibition of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of orcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900701 ! regulation of orcinol biosynthetic process +relationship: negatively_regulates GO:0046197 ! orcinol biosynthetic process + +[Term] +id: GO:1900703 +name: positive regulation of orcinol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "activation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of orcinol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "activation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of orcinol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of orcinol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of orcinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of orcinol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of orcinol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of orcinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900701 ! regulation of orcinol biosynthetic process +relationship: positively_regulates GO:0046197 ! orcinol biosynthetic process + +[Term] +id: GO:1900704 +name: regulation of siderophore biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "regulation of siderophore synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:1900705 +name: negative regulation of siderophore biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "down regulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down-regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "downregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "downregulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "downregulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of siderophore biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "inhibition of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "inhibition of siderophore formation" EXACT [GOC:TermGenie] +synonym: "inhibition of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of siderophore synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900704 ! regulation of siderophore biosynthetic process +relationship: negatively_regulates GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:1900706 +name: positive regulation of siderophore biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "activation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of siderophore biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "activation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "activation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "activation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "up regulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up-regulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of siderophore synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of siderochrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of siderochrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of siderophore anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of siderophore biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of siderophore biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of siderophore biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "upregulation of siderophore biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "upregulation of siderophore formation" EXACT [GOC:TermGenie] +synonym: "upregulation of siderophore synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900704 ! regulation of siderophore biosynthetic process +relationship: positively_regulates GO:0019290 ! siderophore biosynthetic process + +[Term] +id: GO:1900707 +name: regulation of tensidol A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900605 ! tensidol A biosynthetic process + +[Term] +id: GO:1900708 +name: negative regulation of tensidol A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900707 ! regulation of tensidol A biosynthetic process +relationship: negatively_regulates GO:1900605 ! tensidol A biosynthetic process + +[Term] +id: GO:1900709 +name: positive regulation of tensidol A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tensidol A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "activation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of tensidol A biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "activation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol A synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol A anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol A biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol A formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900707 ! regulation of tensidol A biosynthetic process +relationship: positively_regulates GO:1900605 ! tensidol A biosynthetic process + +[Term] +id: GO:1900710 +name: regulation of tensidol B biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900608 ! tensidol B biosynthetic process + +[Term] +id: GO:1900711 +name: negative regulation of tensidol B biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "down regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol B biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "inhibition of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900710 ! regulation of tensidol B biosynthetic process +relationship: negatively_regulates GO:1900608 ! tensidol B biosynthetic process + +[Term] +id: GO:1900712 +name: positive regulation of tensidol B biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tensidol B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "activation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of tensidol B biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "activation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tensidol B synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol B anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol B biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol B formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tensidol B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900710 ! regulation of tensidol B biosynthetic process +relationship: positively_regulates GO:1900608 ! tensidol B biosynthetic process + +[Term] +id: GO:1900713 +name: regulation of violaceol I biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900590 ! violaceol I biosynthetic process + +[Term] +id: GO:1900714 +name: negative regulation of violaceol I biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol I biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900713 ! regulation of violaceol I biosynthetic process +relationship: negatively_regulates GO:1900590 ! violaceol I biosynthetic process + +[Term] +id: GO:1900715 +name: positive regulation of violaceol I biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of violaceol I biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "activation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of violaceol I biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "activation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol I synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol I anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol I biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol I biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol I formation" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol I synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900713 ! regulation of violaceol I biosynthetic process +relationship: positively_regulates GO:1900590 ! violaceol I biosynthetic process + +[Term] +id: GO:1900716 +name: regulation of violaceol II biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900593 ! violaceol II biosynthetic process + +[Term] +id: GO:1900717 +name: negative regulation of violaceol II biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "down regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "downregulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol II biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "inhibition of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900716 ! regulation of violaceol II biosynthetic process +relationship: negatively_regulates GO:1900593 ! violaceol II biosynthetic process + +[Term] +id: GO:1900718 +name: positive regulation of violaceol II biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of violaceol II biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "activation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of violaceol II biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "activation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "up regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of violaceol II synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol II anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol II biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol II biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol II formation" EXACT [GOC:TermGenie] +synonym: "upregulation of violaceol II synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900716 ! regulation of violaceol II biosynthetic process +relationship: positively_regulates GO:1900593 ! violaceol II biosynthetic process + +[Term] +id: GO:1900719 +name: regulation of uterine smooth muscle relaxation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] +synonym: "regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +is_a: GO:1901080 ! regulation of relaxation of smooth muscle +relationship: regulates GO:0044558 ! uterine smooth muscle relaxation + +[Term] +id: GO:1900720 +name: negative regulation of uterine smooth muscle relaxation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] +synonym: "down regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "down regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "down-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "down-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "downregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "downregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "inhibition of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "inhibition of uterine smooth muscle relaxation" NARROW [GOC:TermGenie] +synonym: "negative regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation +is_a: GO:1901081 ! negative regulation of relaxation of smooth muscle +relationship: negatively_regulates GO:0044558 ! uterine smooth muscle relaxation + +[Term] +id: GO:1900721 +name: positive regulation of uterine smooth muscle relaxation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation." [GOC:TermGenie] +synonym: "activation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "activation of uterine smooth muscle relaxation" NARROW [GOC:TermGenie] +synonym: "positive regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "up regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "up regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "up-regulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle relaxation of the uterus" EXACT [GOC:TermGenie] +synonym: "upregulation of uterine smooth muscle relaxation" EXACT [GOC:TermGenie] +is_a: GO:1900719 ! regulation of uterine smooth muscle relaxation +is_a: GO:1901082 ! positive regulation of relaxation of smooth muscle +relationship: positively_regulates GO:0044558 ! uterine smooth muscle relaxation + +[Term] +id: GO:1900722 +name: regulation of protein adenylylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] +synonym: "regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein AMPylation" EXACT [GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0018117 ! protein adenylylation + +[Term] +id: GO:1900723 +name: negative regulation of protein adenylylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] +synonym: "down regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein adenylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein adenylylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein AMPylation" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1900722 ! regulation of protein adenylylation +relationship: negatively_regulates GO:0018117 ! protein adenylylation + +[Term] +id: GO:1900724 +name: positive regulation of protein adenylylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein adenylylation." [GOC:TermGenie] +synonym: "activation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "activation of protein adenylylation" NARROW [GOC:TermGenie] +synonym: "activation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "activation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein AMPylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein adenylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein adenylylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein amino acid adenylylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein AMPylation" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1900722 ! regulation of protein adenylylation +relationship: positively_regulates GO:0018117 ! protein adenylylation + +[Term] +id: GO:1900725 +name: osmoregulated periplasmic glucan metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] +synonym: "osmoregulated periplasmic glucan metabolism" EXACT [GOC:TermGenie] +is_a: GO:0044042 ! glucan metabolic process + +[Term] +id: GO:1900726 +name: osmoregulated periplasmic glucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] +synonym: "osmoregulated periplasmic glucan breakdown" EXACT [GOC:TermGenie] +synonym: "osmoregulated periplasmic glucan catabolism" EXACT [GOC:TermGenie] +synonym: "osmoregulated periplasmic glucan degradation" EXACT [GOC:TermGenie] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process + +[Term] +id: GO:1900727 +name: osmoregulated periplasmic glucan biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan." [GOC:TermGenie, GOC:yaf] +synonym: "osmoregulated periplasmic glucan anabolism" EXACT [GOC:TermGenie] +synonym: "osmoregulated periplasmic glucan biosynthesis" EXACT [GOC:TermGenie] +synonym: "osmoregulated periplasmic glucan formation" EXACT [GOC:TermGenie] +synonym: "osmoregulated periplasmic glucan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009250 ! glucan biosynthetic process +is_a: GO:1900725 ! osmoregulated periplasmic glucan metabolic process + +[Term] +id: GO:1900728 +name: cardiac neural crest cell delamination involved in outflow tract morphogenesis +namespace: biological_process +def: "Any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis." [GOC:hjd, GOC:TermGenie, PMID:18539270] +is_a: GO:0036036 ! cardiac neural crest cell delamination +relationship: part_of GO:0003151 ! outflow tract morphogenesis + +[Term] +id: GO:1900729 +name: regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] +synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor" RELATED [PMID:17157995] +synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] +is_a: GO:2000474 ! regulation of opioid receptor signaling pathway +relationship: regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway + +[Term] +id: GO:1900730 +name: negative regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] +synonym: "down regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] +synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:TermGenie] +is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway +is_a: GO:2000475 ! negative regulation of opioid receptor signaling pathway +relationship: negatively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway + +[Term] +id: GO:1900731 +name: positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting opioid receptor signaling pathway." [GOC:sjw, GOC:TermGenie, PMID:17157995] +synonym: "activation of adenylate cyclase-inhibiting opioid receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of opioid receptor-mediated adenylate cyclase inhibition" RELATED [] +synonym: "up regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of adenylate cyclase-inhibiting opioid receptor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1900729 ! regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway +is_a: GO:2000476 ! positive regulation of opioid receptor signaling pathway +relationship: positively_regulates GO:0031635 ! adenylate cyclase-inhibiting opioid receptor signaling pathway + +[Term] +id: GO:1900732 +name: regulation of polyketide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "regulation of polyketide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0030639 ! polyketide biosynthetic process + +[Term] +id: GO:1900733 +name: negative regulation of polyketide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of polyketide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of polyketide formation" EXACT [GOC:TermGenie] +synonym: "inhibition of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyketide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +relationship: negatively_regulates GO:0030639 ! polyketide biosynthetic process + +[Term] +id: GO:1900734 +name: positive regulation of polyketide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "activation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of polyketide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "activation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "up regulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyketide synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of polyketide anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of polyketide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of polyketide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of polyketide formation" EXACT [GOC:TermGenie] +synonym: "upregulation of polyketide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +relationship: positively_regulates GO:0030639 ! polyketide biosynthetic process + +[Term] +id: GO:1900735 +name: positive regulation of flocculation +namespace: biological_process +alt_id: GO:1900479 +def: "Any process that activates or increases the frequency, rate or extent of flocculation." [GOC:dgf, GOC:TermGenie, PMID:10591965, PMID:15466424, PMID:16568252] +synonym: "activation of flocculation" NARROW [GOC:TermGenie] +synonym: "activation of flocculation via cell wall protein-carbohydrate interaction" NARROW [GOC:TermGenie] +synonym: "positive regulation of flocculation via cell wall protein-carbohydrate interaction" RELATED [] +synonym: "up regulation of flocculation" EXACT [GOC:TermGenie] +synonym: "up regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] +synonym: "up-regulation of flocculation" EXACT [GOC:TermGenie] +synonym: "up-regulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] +synonym: "upregulation of flocculation" EXACT [GOC:TermGenie] +synonym: "upregulation of flocculation via cell wall protein-carbohydrate interaction" EXACT [GOC:TermGenie] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0060256 ! regulation of flocculation +relationship: positively_regulates GO:0000128 ! flocculation + +[Term] +id: GO:1900736 +name: regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] +synonym: "regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:1900737 +name: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "down regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "down regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "down-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "downregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "downregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "downregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "downregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "downregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "inhibition of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "inhibition of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "inhibition of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "inhibition of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "inhibition of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "inhibition of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "negative regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "negative regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] +synonym: "negative regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +relationship: negatively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:1900738 +name: positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "activation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "activation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "activation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "activation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "activation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "activation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "activation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of phospholipase C-activating G-protein coupled receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "positive regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] +synonym: "positive regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "up regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "up-regulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:TermGenie] +synonym: "upregulation of G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "upregulation of G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of PLC-activating GPCR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:1900736 ! regulation of phospholipase C-activating G protein-coupled receptor signaling pathway +relationship: positively_regulates GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway + +[Term] +id: GO:1900739 +name: regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0010821 ! regulation of mitochondrion organization +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + +[Term] +id: GO:1900740 +name: positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1900739 ! regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway +is_a: GO:1901030 ! positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:0001844 ! protein insertion into mitochondrial membrane involved in apoptotic signaling pathway + +[Term] +id: GO:1900741 +name: regulation of filamentous growth of a population of unicellular organisms in response to pH +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:1900428 ! regulation of filamentous growth of a population of unicellular organisms +relationship: regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH + +[Term] +id: GO:1900742 +name: negative regulation of filamentous growth of a population of unicellular organisms in response to pH +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] +synonym: "down regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +synonym: "down-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +synonym: "downregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +synonym: "inhibition of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1900429 ! negative regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH +relationship: negatively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH + +[Term] +id: GO:1900743 +name: positive regulation of filamentous growth of a population of unicellular organisms in response to pH +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to pH." [GOC:di, GOC:TermGenie] +synonym: "activation of filamentous growth of a population of unicellular organisms in response to pH" NARROW [GOC:TermGenie] +synonym: "up regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +synonym: "up-regulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +synonym: "upregulation of filamentous growth of a population of unicellular organisms in response to pH" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1900430 ! positive regulation of filamentous growth of a population of unicellular organisms +is_a: GO:1900741 ! regulation of filamentous growth of a population of unicellular organisms in response to pH +relationship: positively_regulates GO:0036177 ! filamentous growth of a population of unicellular organisms in response to pH + +[Term] +id: GO:1900744 +name: regulation of p38MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie] +synonym: "regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +relationship: regulates GO:0038066 ! p38MAPK cascade + +[Term] +id: GO:1900745 +name: positive regulation of p38MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of p38MAPK cascade." [GOC:TermGenie] +synonym: "activation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "activation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "activation of p38MAPK cascade" NARROW [GOC:TermGenie] +synonym: "positive regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "positive regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of p38MAPK cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of p38MAPK cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of p38MAPK cascade" EXACT [GOC:TermGenie] +is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade +is_a: GO:1900744 ! regulation of p38MAPK cascade +relationship: positively_regulates GO:0038066 ! p38MAPK cascade + +[Term] +id: GO:1900746 +name: regulation of vascular endothelial growth factor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] +synonym: "regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus +relationship: regulates GO:0038084 ! vascular endothelial growth factor signaling pathway + +[Term] +id: GO:1900747 +name: negative regulation of vascular endothelial growth factor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] +synonym: "down regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "inhibition of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway +is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus +relationship: negatively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway + +[Term] +id: GO:1900748 +name: positive regulation of vascular endothelial growth factor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor signaling pathway." [GOC:TermGenie] +synonym: "activation of vascular endothelial growth factor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "activation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "activation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular endothelial growth factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular endothelial growth factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of VEGF signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of VEGF-activated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900746 ! regulation of vascular endothelial growth factor signaling pathway +relationship: positively_regulates GO:0038084 ! vascular endothelial growth factor signaling pathway + +[Term] +id: GO:1900749 +name: (R)-carnitine transport +namespace: biological_process +def: "The directed movement of a (R)-carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798] +synonym: "(-)-Carnitine transport" RELATED [GOC:TermGenie] +synonym: "(-)-L-Carnitine transport" RELATED [GOC:TermGenie] +synonym: "(3R)-3-hydroxy-4-(trimethylammonio)butanoate transport" EXACT [GOC:TermGenie] +synonym: "C7H15NO3 transport" RELATED [GOC:TermGenie] +synonym: "Carnicor transport" RELATED [GOC:TermGenie] +synonym: "Carnitene transport" RELATED [GOC:TermGenie] +synonym: "Carnitine transport" RELATED [GOC:TermGenie] +synonym: "Carnitor transport" RELATED [GOC:TermGenie] +synonym: "L-Carnitine transport" EXACT [GOC:TermGenie] +synonym: "Levocarnitine transport" RELATED [GOC:TermGenie] +synonym: "Vitamin BT transport" RELATED [GOC:TermGenie] +is_a: GO:0015879 ! carnitine transport + +[Term] +id: GO:1900750 +name: oligopeptide binding +namespace: molecular_function +def: "Binding to an oligopeptide." [GOC:TermGenie, PMID:21854595] +synonym: "Oligopeptid binding" RELATED [GOC:TermGenie] +synonym: "oligopeptides binding" EXACT [GOC:TermGenie] +synonym: "oligopeptido binding" RELATED [GOC:TermGenie] +is_a: GO:0042277 ! peptide binding + +[Term] +id: GO:1900751 +name: 4-(trimethylammonio)butanoate transport +namespace: biological_process +def: "The directed movement of a 4-(trimethylammonio)butanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:16365044, PMID:20357772, PMID:20829798] +synonym: "4-(N-trimethylamino)butyrate transport" EXACT [GOC:TermGenie] +synonym: "4-butyrobetaine transport" EXACT [GOC:TermGenie] +synonym: "Actinine transport" RELATED [GOC:TermGenie] +synonym: "butyrobetaine transport" RELATED [GOC:TermGenie] +synonym: "C7H15NO2 transport" RELATED [GOC:TermGenie] +synonym: "deoxycarnitine transport" RELATED [GOC:TermGenie] +synonym: "gamma-Butyrobetain transport" EXACT [GOC:TermGenie] +synonym: "gamma-butyrobetaine transport" EXACT [GOC:TermGenie] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015838 ! amino-acid betaine transport + +[Term] +id: GO:1900752 +name: malonic acid transport +namespace: biological_process +def: "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9128730, PMID:9573154] +synonym: "C3H4O4 transport" RELATED [GOC:TermGenie] +synonym: "H2malo transport" RELATED [GOC:TermGenie] +synonym: "HOOC-CH2-COOH transport" RELATED [GOC:TermGenie] +synonym: "propanedioic acid transport" EXACT [GOC:TermGenie] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:1900753 +name: doxorubicin transport +namespace: biological_process +def: "The directed movement of a doxorubicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:12057006, PMID:15090538, PMID:19063901, PMID:19651502, PMID:9651400] +synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" EXACT [GOC:TermGenie] +synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside transport" RELATED [GOC:TermGenie] +synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione transport" RELATED [GOC:TermGenie] +synonym: "14-hydroxydaunomycin transport" RELATED [GOC:TermGenie] +synonym: "14-hydroxydaunorubicine transport" RELATED [GOC:TermGenie] +synonym: "Adriamycin transport" RELATED [GOC:TermGenie] +synonym: "doxorubicine transport" RELATED [GOC:TermGenie] +synonym: "doxorubicinum transport" RELATED [GOC:TermGenie] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015850 ! organic hydroxy compound transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:1901656 ! glycoside transport + +[Term] +id: GO:1900754 +name: 4-hydroxyphenylacetate transport +namespace: biological_process +def: "The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9315705] +synonym: "(4-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie] +synonym: "(p-hydroxyphenyl)acetate transport" EXACT [GOC:TermGenie] +synonym: "2-(4-hydroxyphenyl)ethanoate transport" EXACT [GOC:TermGenie] +synonym: "4-hydroxybenzeneacetate transport" EXACT [GOC:TermGenie] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:1900756 +name: protein processing in phagocytic vesicle +namespace: biological_process +def: "Protein processing that takes place in the phagosome. Most protein processing in the phagosome represents protein degradation." [GOC:rjd, GOC:TermGenie] +synonym: "peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "protein processing in phagosome" EXACT [GOC:TermGenie] +is_a: GO:0016485 ! protein processing + +[Term] +id: GO:1900757 +name: regulation of D-amino-acid oxidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] +synonym: "regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of new yellow enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1900758 +name: negative regulation of D-amino-acid oxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] +synonym: "down regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "down regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "down-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "downregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "downregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "inhibition of D-amino-acid oxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "inhibition of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "negative regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of new yellow enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity + +[Term] +id: GO:1900759 +name: positive regulation of D-amino-acid oxidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of D-amino-acid oxidase activity." [GOC:TermGenie] +synonym: "activation of D-amino-acid oxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "activation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "activation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "up regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "up regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of new yellow enzyme" RELATED [GOC:TermGenie] +synonym: "upregulation of D-amino-acid oxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [GOC:TermGenie] +synonym: "upregulation of L-amino acid:O2 oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of new yellow enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1900757 ! regulation of D-amino-acid oxidase activity + +[Term] +id: GO:1900760 +name: negative regulation of sterigmatocystin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterigmatocystin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sterigmatocystin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of sterigmatocystin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sterigmatocystin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sterigmatocystin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of sterigmatocystin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of sterigmatocystin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of sterigmatocystin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of sterigmatocystin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of sterigmatocystin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of sterigmatocystin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +relationship: negatively_regulates GO:0045461 ! sterigmatocystin biosynthetic process + +[Term] +id: GO:1900761 +name: averantin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving averantin." [GOC:di, GOC:TermGenie] +synonym: "averantin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1900762 +name: averantin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of averantin." [GOC:di, GOC:TermGenie] +synonym: "averantin breakdown" EXACT [GOC:TermGenie] +synonym: "averantin catabolism" EXACT [GOC:TermGenie] +synonym: "averantin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:1900761 ! averantin metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1900763 +name: averantin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of averantin." [GOC:di, GOC:TermGenie] +synonym: "averantin anabolism" EXACT [GOC:TermGenie] +synonym: "averantin biosynthesis" EXACT [GOC:TermGenie] +synonym: "averantin formation" EXACT [GOC:TermGenie] +synonym: "averantin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900761 ! averantin metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1900764 +name: emericellin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving emericellin." [GOC:di, GOC:TermGenie] +synonym: "emericellin metabolism" EXACT [GOC:TermGenie] +synonym: "Variecoxanthone B metabolic process" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B metabolism" RELATED [GOC:TermGenie] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:2001305 ! xanthone-containing compound metabolic process + +[Term] +id: GO:1900765 +name: emericellin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of emericellin." [GOC:di, GOC:TermGenie] +synonym: "emericellin breakdown" EXACT [GOC:TermGenie] +synonym: "emericellin catabolism" EXACT [GOC:TermGenie] +synonym: "emericellin degradation" EXACT [GOC:TermGenie] +synonym: "Variecoxanthone B breakdown" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B catabolic process" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B catabolism" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B degradation" RELATED [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900764 ! emericellin metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900766 +name: emericellin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of emericellin." [GOC:di, GOC:TermGenie] +synonym: "emericellin anabolism" EXACT [GOC:TermGenie] +synonym: "emericellin biosynthesis" EXACT [GOC:TermGenie] +synonym: "emericellin formation" EXACT [GOC:TermGenie] +synonym: "emericellin synthesis" EXACT [GOC:TermGenie] +synonym: "Variecoxanthone B anabolism" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B formation" RELATED [GOC:TermGenie] +synonym: "Variecoxanthone B synthesis" RELATED [GOC:TermGenie] +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900764 ! emericellin metabolic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:2001307 ! xanthone-containing compound biosynthetic process + +[Term] +id: GO:1900767 +name: fonsecin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fonsecin." [GOC:di, GOC:TermGenie] +synonym: "fonsecin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process + +[Term] +id: GO:1900768 +name: fonsecin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fonsecin." [GOC:di, GOC:TermGenie] +synonym: "fonsecin breakdown" EXACT [GOC:TermGenie] +synonym: "fonsecin catabolism" EXACT [GOC:TermGenie] +synonym: "fonsecin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1900767 ! fonsecin metabolic process +is_a: GO:1900786 ! naphtho-gamma-pyrone catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900769 +name: fonsecin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fonsecin." [GOC:di, GOC:TermGenie] +synonym: "fonsecin anabolism" EXACT [GOC:TermGenie] +synonym: "fonsecin biosynthesis" EXACT [GOC:TermGenie] +synonym: "fonsecin formation" EXACT [GOC:TermGenie] +synonym: "fonsecin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900767 ! fonsecin metabolic process +is_a: GO:1900787 ! naphtho-gamma-pyrone biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900770 +name: fumitremorgin B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumitremorgin B." [GOC:di, GOC:TermGenie] +synonym: "fumitremorgin B metabolism" EXACT [GOC:TermGenie] +synonym: "Lanosulin metabolic process" RELATED [GOC:TermGenie] +synonym: "Lanosulin metabolism" RELATED [GOC:TermGenie] +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0035834 ! indole alkaloid metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:1900771 +name: fumitremorgin B catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumitremorgin B." [GOC:di, GOC:TermGenie] +synonym: "fumitremorgin B breakdown" EXACT [GOC:TermGenie] +synonym: "fumitremorgin B catabolism" EXACT [GOC:TermGenie] +synonym: "fumitremorgin B degradation" EXACT [GOC:TermGenie] +synonym: "Lanosulin breakdown" RELATED [GOC:TermGenie] +synonym: "Lanosulin catabolic process" RELATED [GOC:TermGenie] +synonym: "Lanosulin catabolism" RELATED [GOC:TermGenie] +synonym: "Lanosulin degradation" RELATED [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900770 ! fumitremorgin B metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:1900772 +name: fumitremorgin B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumitremorgin B." [GOC:di, GOC:TermGenie] +synonym: "fumitremorgin B anabolism" EXACT [GOC:TermGenie] +synonym: "fumitremorgin B biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumitremorgin B formation" EXACT [GOC:TermGenie] +synonym: "fumitremorgin B synthesis" EXACT [GOC:TermGenie] +synonym: "Lanosulin anabolism" RELATED [GOC:TermGenie] +synonym: "Lanosulin biosynthesis" RELATED [GOC:TermGenie] +synonym: "Lanosulin biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Lanosulin formation" RELATED [GOC:TermGenie] +synonym: "Lanosulin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900770 ! fumitremorgin B metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process + +[Term] +id: GO:1900773 +name: fumiquinazoline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumiquinazoline." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline metabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazolines metabolic process" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines metabolism" RELATED [GOC:TermGenie] +is_a: GO:0035834 ! indole alkaloid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900774 +name: fumiquinazoline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline breakdown" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline catabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline degradation" EXACT [GOC:TermGenie] +synonym: "fumiquinazolines breakdown" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines catabolic process" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines catabolism" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines degradation" RELATED [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900773 ! fumiquinazoline metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900775 +name: fumiquinazoline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline anabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline formation" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline synthesis" EXACT [GOC:TermGenie] +synonym: "fumiquinazolines anabolism" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines biosynthesis" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines biosynthetic process" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines formation" RELATED [GOC:TermGenie] +synonym: "fumiquinazolines synthesis" RELATED [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:1900773 ! fumiquinazoline metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900776 +name: fumiquinazoline A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumiquinazoline A." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline A metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900773 ! fumiquinazoline metabolic process + +[Term] +id: GO:1900777 +name: fumiquinazoline A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline A." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline A breakdown" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline A catabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline A degradation" EXACT [GOC:TermGenie] +is_a: GO:1900774 ! fumiquinazoline catabolic process +is_a: GO:1900776 ! fumiquinazoline A metabolic process + +[Term] +id: GO:1900778 +name: fumiquinazoline A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline A." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline A anabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline A biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline A formation" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline A synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900775 ! fumiquinazoline biosynthetic process +is_a: GO:1900776 ! fumiquinazoline A metabolic process + +[Term] +id: GO:1900779 +name: fumiquinazoline C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumiquinazoline C." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline C metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900773 ! fumiquinazoline metabolic process + +[Term] +id: GO:1900780 +name: fumiquinazoline C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline C." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline C breakdown" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline C catabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline C degradation" EXACT [GOC:TermGenie] +is_a: GO:1900774 ! fumiquinazoline catabolic process +is_a: GO:1900779 ! fumiquinazoline C metabolic process + +[Term] +id: GO:1900781 +name: fumiquinazoline C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline C." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline C anabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline C biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline C formation" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline C synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900775 ! fumiquinazoline biosynthetic process +is_a: GO:1900779 ! fumiquinazoline C metabolic process + +[Term] +id: GO:1900782 +name: fumiquinazoline F metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumiquinazoline F." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline F metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042430 ! indole-containing compound metabolic process +is_a: GO:1900773 ! fumiquinazoline metabolic process + +[Term] +id: GO:1900783 +name: fumiquinazoline F catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumiquinazoline F." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline F breakdown" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline F catabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline F degradation" EXACT [GOC:TermGenie] +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:1900774 ! fumiquinazoline catabolic process +is_a: GO:1900782 ! fumiquinazoline F metabolic process + +[Term] +id: GO:1900784 +name: fumiquinazoline F biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumiquinazoline F." [GOC:di, GOC:TermGenie] +synonym: "fumiquinazoline F anabolism" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline F biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline F formation" EXACT [GOC:TermGenie] +synonym: "fumiquinazoline F synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:1900775 ! fumiquinazoline biosynthetic process +is_a: GO:1900782 ! fumiquinazoline F metabolic process + +[Term] +id: GO:1900785 +name: naphtho-gamma-pyrone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] +synonym: "naphtho-gamma-pyrone metabolism" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones metabolic process" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones metabolism" RELATED [GOC:TermGenie] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900786 +name: naphtho-gamma-pyrone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] +synonym: "naphtho-gamma-pyrone breakdown" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrone catabolism" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrone degradation" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones breakdown" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones catabolic process" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones catabolism" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones degradation" RELATED [GOC:TermGenie] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900787 +name: naphtho-gamma-pyrone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of naphtho-gamma-pyrone." [GOC:di, GOC:TermGenie] +synonym: "naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie] +synonym: "naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1900785 ! naphtho-gamma-pyrone metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900788 +name: pseurotin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pseurotin A." [GOC:di, GOC:TermGenie] +synonym: "pseurotin A metabolism" EXACT [GOC:TermGenie] +synonym: "Pseurotin metabolic process" RELATED [GOC:TermGenie] +synonym: "Pseurotin metabolism" RELATED [GOC:TermGenie] +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1900789 +name: pseurotin A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pseurotin A." [GOC:di, GOC:TermGenie] +synonym: "pseurotin A breakdown" EXACT [GOC:TermGenie] +synonym: "pseurotin A catabolism" EXACT [GOC:TermGenie] +synonym: "pseurotin A degradation" EXACT [GOC:TermGenie] +synonym: "Pseurotin breakdown" RELATED [GOC:TermGenie] +synonym: "Pseurotin catabolic process" RELATED [GOC:TermGenie] +synonym: "Pseurotin catabolism" RELATED [GOC:TermGenie] +synonym: "Pseurotin degradation" RELATED [GOC:TermGenie] +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900788 ! pseurotin A metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:1900790 +name: pseurotin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pseurotin A." [GOC:di, GOC:TermGenie] +synonym: "pseurotin A anabolism" EXACT [GOC:TermGenie] +synonym: "pseurotin A biosynthesis" EXACT [GOC:TermGenie] +synonym: "pseurotin A formation" EXACT [GOC:TermGenie] +synonym: "pseurotin A synthesis" EXACT [GOC:TermGenie] +synonym: "Pseurotin anabolism" RELATED [GOC:TermGenie] +synonym: "Pseurotin biosynthesis" RELATED [GOC:TermGenie] +synonym: "Pseurotin biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Pseurotin formation" RELATED [GOC:TermGenie] +synonym: "Pseurotin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1900788 ! pseurotin A metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:1900791 +name: shamixanthone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving shamixanthone." [GOC:di, GOC:TermGenie] +synonym: "shamixanthone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1900792 +name: shamixanthone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of shamixanthone." [GOC:di, GOC:TermGenie] +synonym: "shamixanthone breakdown" EXACT [GOC:TermGenie] +synonym: "shamixanthone catabolism" EXACT [GOC:TermGenie] +synonym: "shamixanthone degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900791 ! shamixanthone metabolic process + +[Term] +id: GO:1900793 +name: shamixanthone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of shamixanthone." [GOC:di, GOC:TermGenie] +synonym: "shamixanthone anabolism" EXACT [GOC:TermGenie] +synonym: "shamixanthone biosynthesis" EXACT [GOC:TermGenie] +synonym: "shamixanthone formation" EXACT [GOC:TermGenie] +synonym: "shamixanthone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900791 ! shamixanthone metabolic process + +[Term] +id: GO:1900794 +name: terrequinone A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving terrequinone A." [GOC:di, GOC:TermGenie] +synonym: "terrequinone A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1900795 +name: terrequinone A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of terrequinone A." [GOC:di, GOC:TermGenie] +synonym: "terrequinone A breakdown" EXACT [GOC:TermGenie] +synonym: "terrequinone A catabolism" EXACT [GOC:TermGenie] +synonym: "terrequinone A degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1900794 ! terrequinone A metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1900796 +name: terrequinone A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of terrequinone A." [GOC:di, GOC:TermGenie] +synonym: "terrequinone A anabolism" EXACT [GOC:TermGenie] +synonym: "terrequinone A biosynthesis" EXACT [GOC:TermGenie] +synonym: "terrequinone A formation" EXACT [GOC:TermGenie] +synonym: "terrequinone A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1900794 ! terrequinone A metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1900797 +name: cordyol C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cordyol C." [GOC:di, GOC:TermGenie] +synonym: "cordyol C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0019748 ! secondary metabolic process + +[Term] +id: GO:1900798 +name: cordyol C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cordyol C." [GOC:di, GOC:TermGenie] +synonym: "cordyol C breakdown" EXACT [GOC:TermGenie] +synonym: "cordyol C catabolism" EXACT [GOC:TermGenie] +synonym: "cordyol C degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900797 ! cordyol C metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900799 +name: cordyol C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cordyol C." [GOC:di, GOC:TermGenie] +synonym: "cordyol C anabolism" EXACT [GOC:TermGenie] +synonym: "cordyol C biosynthesis" EXACT [GOC:TermGenie] +synonym: "cordyol C formation" EXACT [GOC:TermGenie] +synonym: "cordyol C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900797 ! cordyol C metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900800 +name: cspyrone B1 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cspyrone B1." [GOC:di, GOC:TermGenie] +synonym: "cspyrone B1 metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:1900801 +name: cspyrone B1 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cspyrone B1." [GOC:di, GOC:TermGenie] +synonym: "cspyrone B1 breakdown" EXACT [GOC:TermGenie] +synonym: "cspyrone B1 catabolism" EXACT [GOC:TermGenie] +synonym: "cspyrone B1 degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900800 ! cspyrone B1 metabolic process +is_a: GO:1901335 ! lactone catabolic process + +[Term] +id: GO:1900802 +name: cspyrone B1 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cspyrone B1." [GOC:di, GOC:TermGenie] +synonym: "cspyrone B1 anabolism" EXACT [GOC:TermGenie] +synonym: "cspyrone B1 biosynthesis" EXACT [GOC:TermGenie] +synonym: "cspyrone B1 formation" EXACT [GOC:TermGenie] +synonym: "cspyrone B1 synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900800 ! cspyrone B1 metabolic process +is_a: GO:1901336 ! lactone biosynthetic process + +[Term] +id: GO:1900803 +name: brevianamide F metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving brevianamide F." [GOC:di, GOC:TermGenie] +synonym: "brevianamide F metabolism" EXACT [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) metabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro metabolic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro metabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline metabolic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline metabolism" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride metabolic process" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride metabolism" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride metabolic process" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride metabolism" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine metabolic process" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine metabolism" RELATED [GOC:TermGenie] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042430 ! indole-containing compound metabolic process + +[Term] +id: GO:1900804 +name: brevianamide F catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of brevianamide F." [GOC:di, GOC:TermGenie] +synonym: "brevianamide F breakdown" EXACT [GOC:TermGenie] +synonym: "brevianamide F catabolism" EXACT [GOC:TermGenie] +synonym: "brevianamide F degradation" EXACT [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) breakdown" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) catabolic process" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) catabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) degradation" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro breakdown" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro catabolic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro catabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro degradation" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline breakdown" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline catabolic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline catabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline degradation" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride breakdown" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride catabolic process" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride catabolism" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride degradation" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride breakdown" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride catabolic process" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride catabolism" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride degradation" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine breakdown" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine catabolic process" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine catabolism" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine degradation" RELATED [GOC:TermGenie] +is_a: GO:0042436 ! indole-containing compound catabolic process +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900803 ! brevianamide F metabolic process + +[Term] +id: GO:1900805 +name: brevianamide F biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of brevianamide F." [GOC:di, GOC:TermGenie] +synonym: "brevianamide F anabolism" EXACT [GOC:TermGenie] +synonym: "brevianamide F biosynthesis" EXACT [GOC:TermGenie] +synonym: "brevianamide F formation" EXACT [GOC:TermGenie] +synonym: "brevianamide F synthesis" EXACT [GOC:TermGenie] +synonym: "C16H17N3O2 anabolism" RELATED [GOC:TermGenie] +synonym: "C16H17N3O2 biosynthesis" RELATED [GOC:TermGenie] +synonym: "C16H17N3O2 biosynthetic process" RELATED [GOC:TermGenie] +synonym: "C16H17N3O2 formation" RELATED [GOC:TermGenie] +synonym: "C16H17N3O2 synthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) anabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) biosynthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) biosynthetic process" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) formation" RELATED [GOC:TermGenie] +synonym: "cyclo-(Trp-Pro) synthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro anabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro biosynthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro biosynthetic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro formation" RELATED [GOC:TermGenie] +synonym: "cyclo-L-Trp-L-Pro synthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline anabolism" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline biosynthesis" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline biosynthetic process" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline formation" RELATED [GOC:TermGenie] +synonym: "cyclo-L-tryptophanyl-L-proline synthesis" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride anabolism" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride biosynthesis" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride biosynthetic process" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride formation" RELATED [GOC:TermGenie] +synonym: "L-prolyl-L-tryptophan anhydride synthesis" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride anabolism" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthesis" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride biosynthetic process" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride formation" RELATED [GOC:TermGenie] +synonym: "L-tryptophyl-L-proline cyclic anhydride synthesis" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine anabolism" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine formation" RELATED [GOC:TermGenie] +synonym: "tryptophan-proline diketopiperazine synthesis" RELATED [GOC:TermGenie] +is_a: GO:0042435 ! indole-containing compound biosynthetic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900803 ! brevianamide F metabolic process + +[Term] +id: GO:1900806 +name: ergot alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ergot alkaloid." [GOC:di, GOC:TermGenie] +synonym: "ergot alkaloid breakdown" EXACT [GOC:TermGenie] +synonym: "ergot alkaloid catabolism" EXACT [GOC:TermGenie] +synonym: "ergot alkaloid degradation" EXACT [GOC:TermGenie] +synonym: "ergot alkaloids breakdown" RELATED [GOC:TermGenie] +synonym: "ergot alkaloids catabolic process" RELATED [GOC:TermGenie] +synonym: "ergot alkaloids catabolism" RELATED [GOC:TermGenie] +synonym: "ergot alkaloids degradation" RELATED [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0035836 ! ergot alkaloid metabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process + +[Term] +id: GO:1900807 +name: fumigaclavine C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumigaclavine C." [GOC:di, GOC:TermGenie] +synonym: "fumigaclavine C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035836 ! ergot alkaloid metabolic process +is_a: GO:1900619 ! acetate ester metabolic process + +[Term] +id: GO:1900808 +name: fumigaclavine C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumigaclavine C." [GOC:di, GOC:TermGenie] +synonym: "fumigaclavine C breakdown" EXACT [GOC:TermGenie] +synonym: "fumigaclavine C catabolism" EXACT [GOC:TermGenie] +synonym: "fumigaclavine C degradation" EXACT [GOC:TermGenie] +is_a: GO:1900806 ! ergot alkaloid catabolic process +is_a: GO:1900807 ! fumigaclavine C metabolic process + +[Term] +id: GO:1900809 +name: fumigaclavine C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumigaclavine C." [GOC:di, GOC:TermGenie] +synonym: "fumigaclavine C anabolism" EXACT [GOC:TermGenie] +synonym: "fumigaclavine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumigaclavine C formation" EXACT [GOC:TermGenie] +synonym: "fumigaclavine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0035837 ! ergot alkaloid biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process +is_a: GO:1900807 ! fumigaclavine C metabolic process + +[Term] +id: GO:1900810 +name: helvolic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving helvolic acid." [GOC:di, GOC:TermGenie] +synonym: "Fumigacin metabolic process" RELATED [GOC:TermGenie] +synonym: "Fumigacin metabolism" RELATED [GOC:TermGenie] +synonym: "helvolic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1900619 ! acetate ester metabolic process + +[Term] +id: GO:1900811 +name: helvolic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of helvolic acid." [GOC:di, GOC:TermGenie] +synonym: "Fumigacin breakdown" RELATED [GOC:TermGenie] +synonym: "Fumigacin catabolic process" RELATED [GOC:TermGenie] +synonym: "Fumigacin catabolism" RELATED [GOC:TermGenie] +synonym: "Fumigacin degradation" RELATED [GOC:TermGenie] +synonym: "helvolic acid breakdown" EXACT [GOC:TermGenie] +synonym: "helvolic acid catabolism" EXACT [GOC:TermGenie] +synonym: "helvolic acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1900810 ! helvolic acid metabolic process + +[Term] +id: GO:1900812 +name: helvolic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of helvolic acid." [GOC:di, GOC:TermGenie] +synonym: "Fumigacin anabolism" RELATED [GOC:TermGenie] +synonym: "Fumigacin biosynthesis" RELATED [GOC:TermGenie] +synonym: "Fumigacin biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Fumigacin formation" RELATED [GOC:TermGenie] +synonym: "Fumigacin synthesis" RELATED [GOC:TermGenie] +synonym: "helvolic acid anabolism" EXACT [GOC:TermGenie] +synonym: "helvolic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "helvolic acid formation" EXACT [GOC:TermGenie] +synonym: "helvolic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process +is_a: GO:1900810 ! helvolic acid metabolic process + +[Term] +id: GO:1900813 +name: monodictyphenone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monodictyphenone." [GOC:di, GOC:TermGenie] +synonym: "monodictyphenone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1900814 +name: monodictyphenone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monodictyphenone." [GOC:di, GOC:TermGenie] +synonym: "monodictyphenone breakdown" EXACT [GOC:TermGenie] +synonym: "monodictyphenone catabolism" EXACT [GOC:TermGenie] +synonym: "monodictyphenone degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900813 ! monodictyphenone metabolic process + +[Term] +id: GO:1900815 +name: monodictyphenone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monodictyphenone." [GOC:di, GOC:TermGenie] +synonym: "monodictyphenone anabolism" EXACT [GOC:TermGenie] +synonym: "monodictyphenone biosynthesis" EXACT [GOC:TermGenie] +synonym: "monodictyphenone formation" EXACT [GOC:TermGenie] +synonym: "monodictyphenone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900813 ! monodictyphenone metabolic process + +[Term] +id: GO:1900816 +name: ochratoxin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ochratoxin A." [GOC:di, GOC:TermGenie] +synonym: "Ochratoxin A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:1900817 +name: ochratoxin A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ochratoxin A." [GOC:di, GOC:TermGenie] +synonym: "ochratoxin A breakdown" EXACT [GOC:TermGenie] +synonym: "ochratoxin A catabolism" EXACT [GOC:TermGenie] +synonym: "ochratoxin A degradation" EXACT [GOC:TermGenie] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900816 ! ochratoxin A metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901569 ! fatty acid derivative catabolic process + +[Term] +id: GO:1900818 +name: ochratoxin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ochratoxin A." [GOC:di, GOC:TermGenie] +synonym: "Ochratoxin A anabolism" EXACT [GOC:TermGenie] +synonym: "Ochratoxin A biosynthesis" EXACT [GOC:TermGenie] +synonym: "Ochratoxin A formation" EXACT [GOC:TermGenie] +synonym: "Ochratoxin A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1900816 ! ochratoxin A metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process + +[Term] +id: GO:1900819 +name: orlandin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving orlandin." [GOC:di, GOC:TermGenie] +synonym: "orlandin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1900820 +name: orlandin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of orlandin." [GOC:di, GOC:TermGenie] +synonym: "orlandin breakdown" EXACT [GOC:TermGenie] +synonym: "orlandin catabolism" EXACT [GOC:TermGenie] +synonym: "orlandin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0090487 ! secondary metabolite catabolic process +is_a: GO:1900819 ! orlandin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900821 +name: orlandin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of orlandin." [GOC:di, GOC:TermGenie] +synonym: "orlandin anabolism" EXACT [GOC:TermGenie] +synonym: "orlandin biosynthesis" EXACT [GOC:TermGenie] +synonym: "orlandin formation" EXACT [GOC:TermGenie] +synonym: "orlandin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0044550 ! secondary metabolite biosynthetic process +is_a: GO:1900819 ! orlandin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900822 +name: regulation of ergot alkaloid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:0035837 ! ergot alkaloid biosynthetic process + +[Term] +id: GO:1900823 +name: negative regulation of ergot alkaloid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "inhibition of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process +relationship: negatively_regulates GO:0035837 ! ergot alkaloid biosynthetic process + +[Term] +id: GO:1900824 +name: positive regulation of ergot alkaloid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "activation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of ergot alkaloid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "activation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ergot alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ergot alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ergot alkaloid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ergot alkaloid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ergot alkaloid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process +relationship: positively_regulates GO:0035837 ! ergot alkaloid biosynthetic process + +[Term] +id: GO:1900825 +name: regulation of membrane depolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] +is_a: GO:0098902 ! regulation of membrane depolarization during action potential +relationship: regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential + +[Term] +id: GO:1900826 +name: negative regulation of membrane depolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] +synonym: "down regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane depolarization during of cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] +is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential +is_a: GO:1904180 ! negative regulation of membrane depolarization +relationship: negatively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential + +[Term] +id: GO:1900827 +name: positive regulation of membrane depolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during a cardiac muscle cell action potential." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:TermGenie] +synonym: "activation of membrane depolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane depolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential +is_a: GO:1904181 ! positive regulation of membrane depolarization +relationship: positively_regulates GO:0086012 ! membrane depolarization during cardiac muscle cell action potential + +[Term] +id: GO:1900828 +name: D-tyrosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-tyrosine." [GOC:TermGenie, PMID:10766779] +synonym: "D-tyrosine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006570 ! tyrosine metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:1900829 +name: D-tyrosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-tyrosine." [GOC:TermGenie, PMID:10766779] +synonym: "D-tyrosine breakdown" EXACT [GOC:TermGenie] +synonym: "D-tyrosine catabolism" EXACT [GOC:TermGenie] +synonym: "D-tyrosine degradation" EXACT [GOC:TermGenie] +is_a: GO:0006572 ! tyrosine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:1900828 ! D-tyrosine metabolic process + +[Term] +id: GO:1900830 +name: obsolete D-tyrosine biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of D-tyrosine." [GOC:TermGenie, PMID:10766779] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "D-tyrosine anabolism" EXACT [GOC:TermGenie] +synonym: "D-tyrosine biosynthesis" EXACT [GOC:TermGenie] +synonym: "D-tyrosine formation" EXACT [GOC:TermGenie] +synonym: "D-tyrosine synthesis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1900831 +name: D-leucine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-leucine." [GOC:TermGenie, PMID:10918062] +synonym: "D-leucine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006551 ! leucine metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:1900832 +name: D-leucine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-leucine." [GOC:TermGenie, PMID:10918062] +synonym: "D-leucine breakdown" EXACT [GOC:TermGenie] +synonym: "D-leucine catabolism" EXACT [GOC:TermGenie] +synonym: "D-leucine degradation" EXACT [GOC:TermGenie] +is_a: GO:0006552 ! leucine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:1900831 ! D-leucine metabolic process + +[Term] +id: GO:1900833 +name: D-leucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-leucine." [GOC:TermGenie, PMID:10918062] +synonym: "D-leucine anabolism" EXACT [GOC:TermGenie] +synonym: "D-leucine biosynthesis" EXACT [GOC:TermGenie] +synonym: "D-leucine formation" EXACT [GOC:TermGenie] +synonym: "D-leucine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009098 ! leucine biosynthetic process +is_a: GO:0046437 ! D-amino acid biosynthetic process +is_a: GO:1900831 ! D-leucine metabolic process + +[Term] +id: GO:1900834 +name: regulation of emericellin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of emericellin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of emericellin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of emericellin formation" EXACT [GOC:TermGenie] +synonym: "regulation of emericellin synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of Variecoxanthone B anabolism" RELATED [GOC:TermGenie] +synonym: "regulation of Variecoxanthone B biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of Variecoxanthone B biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of Variecoxanthone B formation" RELATED [GOC:TermGenie] +synonym: "regulation of Variecoxanthone B synthesis" RELATED [GOC:TermGenie] +is_a: GO:1900183 ! regulation of xanthone-containing compound biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900766 ! emericellin biosynthetic process + +[Term] +id: GO:1900835 +name: negative regulation of emericellin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of emericellin biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:1900184 ! negative regulation of xanthone-containing compound biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900834 ! regulation of emericellin biosynthetic process +relationship: negatively_regulates GO:1900766 ! emericellin biosynthetic process + +[Term] +id: GO:1900836 +name: positive regulation of emericellin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of emericellin biosynthetic process." [GOC:di, GOC:TermGenie] +is_a: GO:1900185 ! positive regulation of xanthone-containing compound biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900834 ! regulation of emericellin biosynthetic process +relationship: positively_regulates GO:1900766 ! emericellin biosynthetic process + +[Term] +id: GO:1900837 +name: regulation of fumigaclavine C biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of fumigaclavine C anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of fumigaclavine C biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of fumigaclavine C formation" EXACT [GOC:TermGenie] +synonym: "regulation of fumigaclavine C synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900822 ! regulation of ergot alkaloid biosynthetic process +relationship: regulates GO:1900809 ! fumigaclavine C biosynthetic process + +[Term] +id: GO:1900838 +name: negative regulation of fumigaclavine C biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "inhibition of fumigaclavine C biosynthetic process" NARROW [GOC:TermGenie] +is_a: GO:1900823 ! negative regulation of ergot alkaloid biosynthetic process +is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process +relationship: negatively_regulates GO:1900809 ! fumigaclavine C biosynthetic process + +[Term] +id: GO:1900839 +name: positive regulation of fumigaclavine C biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fumigaclavine C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of fumigaclavine C biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:1900824 ! positive regulation of ergot alkaloid biosynthetic process +is_a: GO:1900837 ! regulation of fumigaclavine C biosynthetic process +relationship: positively_regulates GO:1900809 ! fumigaclavine C biosynthetic process + +[Term] +id: GO:1900840 +name: regulation of helvolic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900812 ! helvolic acid biosynthetic process + +[Term] +id: GO:1900841 +name: negative regulation of helvolic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process +relationship: negatively_regulates GO:1900812 ! helvolic acid biosynthetic process + +[Term] +id: GO:1900842 +name: positive regulation of helvolic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of helvolic acid biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of helvolic acid biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900840 ! regulation of helvolic acid biosynthetic process +relationship: positively_regulates GO:1900812 ! helvolic acid biosynthetic process + +[Term] +id: GO:1900843 +name: regulation of monodictyphenone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of monodictyphenone anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of monodictyphenone biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of monodictyphenone formation" EXACT [GOC:TermGenie] +synonym: "regulation of monodictyphenone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900815 ! monodictyphenone biosynthetic process + +[Term] +id: GO:1900844 +name: negative regulation of monodictyphenone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process +relationship: negatively_regulates GO:1900815 ! monodictyphenone biosynthetic process + +[Term] +id: GO:1900845 +name: positive regulation of monodictyphenone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monodictyphenone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "upregulation of monodictyphenone biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900843 ! regulation of monodictyphenone biosynthetic process +relationship: positively_regulates GO:1900815 ! monodictyphenone biosynthetic process + +[Term] +id: GO:1900846 +name: regulation of naphtho-gamma-pyrone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrone anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrone biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrone formation" EXACT [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrone synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrones anabolism" RELATED [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrones biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrones biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrones formation" RELATED [GOC:TermGenie] +synonym: "regulation of naphtho-gamma-pyrones synthesis" RELATED [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +relationship: regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process + +[Term] +id: GO:1900847 +name: negative regulation of naphtho-gamma-pyrone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process +relationship: negatively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process + +[Term] +id: GO:1900848 +name: positive regulation of naphtho-gamma-pyrone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of naphtho-gamma-pyrone biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of naphtho-gamma-pyrone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of naphtho-gamma-pyrone biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900846 ! regulation of naphtho-gamma-pyrone biosynthetic process +relationship: positively_regulates GO:1900787 ! naphtho-gamma-pyrone biosynthetic process + +[Term] +id: GO:1900849 +name: regulation of pseurotin A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of pseurotin A anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of pseurotin A biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of pseurotin A formation" EXACT [GOC:TermGenie] +synonym: "regulation of pseurotin A synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of Pseurotin anabolism" RELATED [GOC:TermGenie] +synonym: "regulation of Pseurotin biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of Pseurotin biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of Pseurotin formation" RELATED [GOC:TermGenie] +synonym: "regulation of Pseurotin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +relationship: regulates GO:1900790 ! pseurotin A biosynthetic process + +[Term] +id: GO:1900850 +name: negative regulation of pseurotin A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process +relationship: negatively_regulates GO:1900790 ! pseurotin A biosynthetic process + +[Term] +id: GO:1900851 +name: positive regulation of pseurotin A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of pseurotin A biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:1900849 ! regulation of pseurotin A biosynthetic process +relationship: positively_regulates GO:1900790 ! pseurotin A biosynthetic process + +[Term] +id: GO:1900852 +name: regulation of terrequinone A biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of terrequinone A anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of terrequinone A biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of terrequinone A formation" EXACT [GOC:TermGenie] +synonym: "regulation of terrequinone A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900796 ! terrequinone A biosynthetic process + +[Term] +id: GO:1900853 +name: negative regulation of terrequinone A biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process +relationship: negatively_regulates GO:1900796 ! terrequinone A biosynthetic process + +[Term] +id: GO:1900854 +name: positive regulation of terrequinone A biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of terrequinone A biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of terrequinone A biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900852 ! regulation of terrequinone A biosynthetic process +relationship: positively_regulates GO:1900796 ! terrequinone A biosynthetic process + +[Term] +id: GO:1900855 +name: regulation of fumitremorgin B biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of fumitremorgin B anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of fumitremorgin B biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of fumitremorgin B formation" EXACT [GOC:TermGenie] +synonym: "regulation of fumitremorgin B synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of Lanosulin anabolism" RELATED [GOC:TermGenie] +synonym: "regulation of Lanosulin biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of Lanosulin biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of Lanosulin formation" RELATED [GOC:TermGenie] +synonym: "regulation of Lanosulin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900772 ! fumitremorgin B biosynthetic process + +[Term] +id: GO:1900856 +name: negative regulation of fumitremorgin B biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process +relationship: negatively_regulates GO:1900772 ! fumitremorgin B biosynthetic process + +[Term] +id: GO:1900857 +name: positive regulation of fumitremorgin B biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fumitremorgin B biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of fumitremorgin B biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900855 ! regulation of fumitremorgin B biosynthetic process +relationship: positively_regulates GO:1900772 ! fumitremorgin B biosynthetic process + +[Term] +id: GO:1900858 +name: regulation of brevianamide F biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of brevianamide F anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of brevianamide F biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of brevianamide F formation" EXACT [GOC:TermGenie] +synonym: "regulation of brevianamide F synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900805 ! brevianamide F biosynthetic process + +[Term] +id: GO:1900859 +name: negative regulation of brevianamide F biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process +relationship: negatively_regulates GO:1900805 ! brevianamide F biosynthetic process + +[Term] +id: GO:1900860 +name: positive regulation of brevianamide F biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of brevianamide F biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "up regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of brevianamide F biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900858 ! regulation of brevianamide F biosynthetic process +relationship: positively_regulates GO:1900805 ! brevianamide F biosynthetic process + +[Term] +id: GO:1900861 +name: regulation of cordyol C biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +relationship: regulates GO:1900799 ! cordyol C biosynthetic process + +[Term] +id: GO:1900862 +name: negative regulation of cordyol C biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1900861 ! regulation of cordyol C biosynthetic process +relationship: negatively_regulates GO:1900799 ! cordyol C biosynthetic process + +[Term] +id: GO:1900863 +name: positive regulation of cordyol C biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cordyol C biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of cordyol C biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cordyol C biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1900861 ! regulation of cordyol C biosynthetic process +relationship: positively_regulates GO:1900799 ! cordyol C biosynthetic process + +[Term] +id: GO:1900864 +name: mitochondrial RNA modification +namespace: biological_process +def: "Any RNA modification that takes place in mitochondrion." [GOC:TermGenie] +synonym: "mitochondrial RNA editing" NARROW [GOC:TermGenie] +is_a: GO:0000959 ! mitochondrial RNA metabolic process +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:1900865 +name: chloroplast RNA modification +namespace: biological_process +def: "Any RNA modification that takes place in chloroplast." [GOC:TermGenie] +synonym: "RNA editing in chloroplast" NARROW [GOC:TermGenie] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:1900866 +name: glycolate transport +namespace: biological_process +def: "The directed movement of a glycolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:1900867 +name: sarcinapterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sarcinapterin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "sarcinapterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:2001115 ! methanopterin-containing compound metabolic process + +[Term] +id: GO:1900868 +name: sarcinapterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sarcinapterin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "sarcinapterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process +is_a: GO:1900867 ! sarcinapterin metabolic process +is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process + +[Term] +id: GO:1900869 +name: tatiopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tatiopterin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "tatiopterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:1900870 +name: tatiopterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tatiopterin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "tatiopterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1900869 ! tatiopterin metabolic process + +[Term] +id: GO:1900871 +name: chloroplast mRNA modification +namespace: biological_process +def: "The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:TermGenie, PMID:1653905] +synonym: "chloroplast mRNA editing" NARROW [] +synonym: "mRNA editing in chloroplast" NARROW [GOC:TermGenie] +is_a: GO:0016556 ! mRNA modification +is_a: GO:1900865 ! chloroplast RNA modification + +[Term] +id: GO:1900872 +name: pentadec-1-ene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "pentadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900873 +name: pentadec-1-ene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "pentadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "pentadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "pentadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "pentadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900872 ! pentadec-1-ene metabolic process + +[Term] +id: GO:1900874 +name: heptadec-1-ene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "heptadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900875 +name: heptadec-1-ene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of heptadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "heptadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "heptadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "heptadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "heptadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900874 ! heptadec-1-ene metabolic process + +[Term] +id: GO:1900876 +name: nonadec-1-ene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900877 +name: nonadec-1-ene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900876 ! nonadec-1-ene metabolic process + +[Term] +id: GO:1900878 +name: (Z)-nonadeca-1,14-diene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "(Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900673 ! olefin metabolic process + +[Term] +id: GO:1900879 +name: (Z)-nonadeca-1,14-diene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (Z)-nonadeca-1,14-diene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "(Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "(Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "(Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "(Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900674 ! olefin biosynthetic process +is_a: GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process + +[Term] +id: GO:1900880 +name: 18-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900881 +name: 18-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 18-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900880 ! 18-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900882 +name: 17-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1900883 +name: 17-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 17-methylnonadec-1-ene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1900882 ! 17-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900884 +name: regulation of tridecane biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "regulation of tridecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900893 ! regulation of tridecane metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:1900632 ! tridecane biosynthetic process + +[Term] +id: GO:1900885 +name: negative regulation of tridecane biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "down regulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tridecane anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of tridecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of tridecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tridecane formation" NARROW [GOC:TermGenie] +synonym: "inhibition of tridecane synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tridecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900884 ! regulation of tridecane biosynthetic process +is_a: GO:1900894 ! negative regulation of tridecane metabolic process +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +relationship: negatively_regulates GO:1900632 ! tridecane biosynthetic process + +[Term] +id: GO:1900886 +name: positive regulation of tridecane biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tridecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tridecane anabolism" NARROW [GOC:TermGenie] +synonym: "activation of tridecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of tridecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tridecane formation" NARROW [GOC:TermGenie] +synonym: "activation of tridecane synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900884 ! regulation of tridecane biosynthetic process +is_a: GO:1900895 ! positive regulation of tridecane metabolic process +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +relationship: positively_regulates GO:1900632 ! tridecane biosynthetic process + +[Term] +id: GO:1900887 +name: regulation of pentadecane biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of pentadecane anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of pentadecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of pentadecane formation" EXACT [GOC:TermGenie] +synonym: "regulation of pentadecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900890 ! regulation of pentadecane metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:1900634 ! pentadecane biosynthetic process + +[Term] +id: GO:1900888 +name: negative regulation of pentadecane biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "down regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "downregulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of pentadecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of pentadecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "inhibition of pentadecane synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +is_a: GO:1900887 ! regulation of pentadecane biosynthetic process +is_a: GO:1900891 ! negative regulation of pentadecane metabolic process +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +relationship: negatively_regulates GO:1900634 ! pentadecane biosynthetic process + +[Term] +id: GO:1900889 +name: positive regulation of pentadecane biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pentadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of pentadecane anabolism" NARROW [GOC:TermGenie] +synonym: "activation of pentadecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of pentadecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of pentadecane formation" NARROW [GOC:TermGenie] +synonym: "activation of pentadecane synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "up regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of pentadecane synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of pentadecane anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of pentadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of pentadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of pentadecane formation" RELATED [GOC:TermGenie] +synonym: "upregulation of pentadecane synthesis" RELATED [GOC:TermGenie] +is_a: GO:1900887 ! regulation of pentadecane biosynthetic process +is_a: GO:1900892 ! positive regulation of pentadecane metabolic process +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +relationship: positively_regulates GO:1900634 ! pentadecane biosynthetic process + +[Term] +id: GO:1900890 +name: regulation of pentadecane metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of pentadecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:1900633 ! pentadecane metabolic process + +[Term] +id: GO:1900891 +name: negative regulation of pentadecane metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of pentadecane metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of pentadecane metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900890 ! regulation of pentadecane metabolic process +relationship: negatively_regulates GO:1900633 ! pentadecane metabolic process + +[Term] +id: GO:1900892 +name: positive regulation of pentadecane metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pentadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of pentadecane metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of pentadecane metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of pentadecane metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of pentadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of pentadecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900890 ! regulation of pentadecane metabolic process +relationship: positively_regulates GO:1900633 ! pentadecane metabolic process + +[Term] +id: GO:1900893 +name: regulation of tridecane metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tridecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:1900631 ! tridecane metabolic process + +[Term] +id: GO:1900894 +name: negative regulation of tridecane metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of tridecane metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tridecane metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of tridecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900893 ! regulation of tridecane metabolic process +relationship: negatively_regulates GO:1900631 ! tridecane metabolic process + +[Term] +id: GO:1900895 +name: positive regulation of tridecane metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tridecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tridecane metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tridecane metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tridecane metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of tridecane metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tridecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900893 ! regulation of tridecane metabolic process +relationship: positively_regulates GO:1900631 ! tridecane metabolic process + +[Term] +id: GO:1900896 +name: regulation of heptadecane biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of heptadecane anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of heptadecane biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of heptadecane formation" EXACT [GOC:TermGenie] +synonym: "regulation of heptadecane synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900899 ! regulation of heptadecane metabolic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: regulates GO:1900636 ! heptadecane biosynthetic process + +[Term] +id: GO:1900897 +name: negative regulation of heptadecane biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "down regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "downregulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of heptadecane anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of heptadecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of heptadecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of heptadecane formation" NARROW [GOC:TermGenie] +synonym: "inhibition of heptadecane synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +is_a: GO:1900896 ! regulation of heptadecane biosynthetic process +is_a: GO:1900900 ! negative regulation of heptadecane metabolic process +is_a: GO:1901578 ! negative regulation of alkane biosynthetic process +relationship: negatively_regulates GO:1900636 ! heptadecane biosynthetic process + +[Term] +id: GO:1900898 +name: positive regulation of heptadecane biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heptadecane biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of heptadecane anabolism" NARROW [GOC:TermGenie] +synonym: "activation of heptadecane biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of heptadecane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of heptadecane formation" NARROW [GOC:TermGenie] +synonym: "activation of heptadecane synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "up regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of heptadecane synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of heptadecane anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of heptadecane biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of heptadecane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of heptadecane formation" RELATED [GOC:TermGenie] +synonym: "upregulation of heptadecane synthesis" RELATED [GOC:TermGenie] +is_a: GO:1900896 ! regulation of heptadecane biosynthetic process +is_a: GO:1900901 ! positive regulation of heptadecane metabolic process +is_a: GO:1901579 ! positive regulation of alkane biosynthetic process +relationship: positively_regulates GO:1900636 ! heptadecane biosynthetic process + +[Term] +id: GO:1900899 +name: regulation of heptadecane metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of heptadecane metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:1900635 ! heptadecane metabolic process + +[Term] +id: GO:1900900 +name: negative regulation of heptadecane metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of heptadecane metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of heptadecane metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900899 ! regulation of heptadecane metabolic process +relationship: negatively_regulates GO:1900635 ! heptadecane metabolic process + +[Term] +id: GO:1900901 +name: positive regulation of heptadecane metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heptadecane metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of heptadecane metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of heptadecane metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of heptadecane metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of heptadecane metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of heptadecane metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900899 ! regulation of heptadecane metabolic process +relationship: positively_regulates GO:1900635 ! heptadecane metabolic process + +[Term] +id: GO:1900902 +name: regulation of hexadecanal biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of hexadecanal anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of hexadecanal biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hexadecanal formation" EXACT [GOC:TermGenie] +synonym: "regulation of hexadecanal synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of palmitaldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of palmitaldehyde biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900905 ! regulation of hexadecanal metabolic process +relationship: regulates GO:0006634 ! hexadecanal biosynthetic process + +[Term] +id: GO:1900903 +name: negative regulation of hexadecanal biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "down regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "downregulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of hexadecanal anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of hexadecanal biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hexadecanal biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hexadecanal formation" NARROW [GOC:TermGenie] +synonym: "inhibition of hexadecanal synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of palmitaldehyde biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process +is_a: GO:1900906 ! negative regulation of hexadecanal metabolic process +relationship: negatively_regulates GO:0006634 ! hexadecanal biosynthetic process + +[Term] +id: GO:1900904 +name: positive regulation of hexadecanal biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hexadecanal biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of hexadecanal anabolism" NARROW [GOC:TermGenie] +synonym: "activation of hexadecanal biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of hexadecanal biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of hexadecanal formation" NARROW [GOC:TermGenie] +synonym: "activation of hexadecanal synthesis" NARROW [GOC:TermGenie] +synonym: "activation of palmitaldehyde biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "up regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of hexadecanal anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of hexadecanal biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of hexadecanal biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hexadecanal formation" RELATED [GOC:TermGenie] +synonym: "upregulation of hexadecanal synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of palmitaldehyde biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of palmitaldehyde biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900902 ! regulation of hexadecanal biosynthetic process +is_a: GO:1900907 ! positive regulation of hexadecanal metabolic process +relationship: positively_regulates GO:0006634 ! hexadecanal biosynthetic process + +[Term] +id: GO:1900905 +name: regulation of hexadecanal metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of hexadecanal metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0046458 ! hexadecanal metabolic process + +[Term] +id: GO:1900906 +name: negative regulation of hexadecanal metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of hexadecanal metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900905 ! regulation of hexadecanal metabolic process +relationship: negatively_regulates GO:0046458 ! hexadecanal metabolic process + +[Term] +id: GO:1900907 +name: positive regulation of hexadecanal metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hexadecanal metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of hexadecanal metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of hexadecanal metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of hexadecanal metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hexadecanal metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900905 ! regulation of hexadecanal metabolic process +relationship: positively_regulates GO:0046458 ! hexadecanal metabolic process + +[Term] +id: GO:1900908 +name: regulation of olefin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of olefin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:1900673 ! olefin metabolic process + +[Term] +id: GO:1900909 +name: negative regulation of olefin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of olefin metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of olefin metabolism" RELATED [GOC:TermGenie] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: negatively_regulates GO:1900673 ! olefin metabolic process + +[Term] +id: GO:1900910 +name: positive regulation of olefin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of olefin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of olefin metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of olefin metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of olefin metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of olefin metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of olefin metabolism" RELATED [GOC:TermGenie] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: positively_regulates GO:1900673 ! olefin metabolic process + +[Term] +id: GO:1900911 +name: regulation of olefin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of olefin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of olefin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of olefin formation" EXACT [GOC:TermGenie] +synonym: "regulation of olefin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900674 ! olefin biosynthetic process + +[Term] +id: GO:1900912 +name: negative regulation of olefin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "down regulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "downregulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of olefin anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of olefin biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of olefin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of olefin formation" NARROW [GOC:TermGenie] +synonym: "inhibition of olefin synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of olefin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +relationship: negatively_regulates GO:1900674 ! olefin biosynthetic process + +[Term] +id: GO:1900913 +name: positive regulation of olefin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of olefin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of olefin anabolism" NARROW [GOC:TermGenie] +synonym: "activation of olefin biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of olefin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of olefin formation" NARROW [GOC:TermGenie] +synonym: "activation of olefin synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "up regulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of olefin synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of olefin anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of olefin biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of olefin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of olefin formation" RELATED [GOC:TermGenie] +synonym: "upregulation of olefin synthesis" RELATED [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +relationship: positively_regulates GO:1900674 ! olefin biosynthetic process + +[Term] +id: GO:1900914 +name: regulation of octadecene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 1-octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of octadecene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of octadecene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of octadecene formation" EXACT [GOC:TermGenie] +synonym: "regulation of octadecene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900917 ! regulation of octadecene metabolic process +relationship: regulates GO:1900682 ! octadecene biosynthetic process + +[Term] +id: GO:1900915 +name: negative regulation of octadecene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "down regulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "downregulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of 1-octadecene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene formation" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of octadecene synthesis" RELATED [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900914 ! regulation of octadecene biosynthetic process +is_a: GO:1900918 ! negative regulation of octadecene metabolic process +relationship: negatively_regulates GO:1900682 ! octadecene biosynthetic process + +[Term] +id: GO:1900916 +name: positive regulation of octadecene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of octadecene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "activation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of octadecene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "activation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "up regulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of octadecene synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of 1-octadecene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of octadecene anabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of octadecene biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of octadecene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of octadecene formation" RELATED [GOC:TermGenie] +synonym: "upregulation of octadecene synthesis" RELATED [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900914 ! regulation of octadecene biosynthetic process +is_a: GO:1900919 ! positive regulation of octadecene metabolic process +relationship: positively_regulates GO:1900682 ! octadecene biosynthetic process + +[Term] +id: GO:1900917 +name: regulation of octadecene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of octadecene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900681 ! octadecene metabolic process + +[Term] +id: GO:1900918 +name: negative regulation of octadecene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of octadecene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of octadecene metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of octadecene metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900917 ! regulation of octadecene metabolic process +relationship: negatively_regulates GO:1900681 ! octadecene metabolic process + +[Term] +id: GO:1900919 +name: positive regulation of octadecene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of octadecene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of octadecene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of octadecene metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of octadecene metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of octadecene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of octadecene metabolism" RELATED [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900917 ! regulation of octadecene metabolic process +relationship: positively_regulates GO:1900681 ! octadecene metabolic process + +[Term] +id: GO:1900923 +name: regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] +synonym: "regulation of glycine import" BROAD [] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1903804 ! glycine import across plasma membrane + +[Term] +id: GO:1900924 +name: negative regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] +synonym: "down regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] +synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] +synonym: "negative regulation of glycine import" BROAD [] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1900923 ! regulation of glycine import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane + +[Term] +id: GO:1900925 +name: positive regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie] +synonym: "activation of glycine import" NARROW [GOC:TermGenie] +synonym: "positive regulation of glycine import" BROAD [] +synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1900923 ! regulation of glycine import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane + +[Term] +id: GO:1900926 +name: regulation of L-threonine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] +synonym: "regulation of L-threonine import" BROAD [] +synonym: "regulation of L-threonine uptake" EXACT [GOC:TermGenie] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1903807 ! L-threonine import across plasma membrane + +[Term] +id: GO:1900927 +name: negative regulation of L-threonine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] +synonym: "down regulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "down regulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "downregulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "downregulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "inhibition of L-threonine import" NARROW [GOC:TermGenie] +synonym: "inhibition of L-threonine uptake" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-threonine uptake" RELATED [GOC:TermGenie] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:1903807 ! L-threonine import across plasma membrane + +[Term] +id: GO:1900928 +name: positive regulation of L-threonine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-threonine import into cell." [GOC:TermGenie] +synonym: "activation of L-threonine import" NARROW [GOC:TermGenie] +synonym: "activation of L-threonine uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-threonine import" BROAD [] +synonym: "positive regulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "up regulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-threonine uptake" RELATED [GOC:TermGenie] +synonym: "upregulation of L-threonine import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-threonine uptake" RELATED [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1900926 ! regulation of L-threonine import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:1903807 ! L-threonine import across plasma membrane + +[Term] +id: GO:1900929 +name: regulation of L-tyrosine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] +synonym: "regulation of L-tyrosine import" BROAD [] +synonym: "regulation of L-tyrosine uptake" EXACT [GOC:TermGenie] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1903808 ! L-tyrosine import across plasma membrane + +[Term] +id: GO:1900930 +name: negative regulation of L-tyrosine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] +synonym: "down regulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "down regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "downregulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "downregulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "inhibition of L-tyrosine import" NARROW [GOC:TermGenie] +synonym: "inhibition of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "negative regulation of L-tyrosine import" BROAD [] +synonym: "negative regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:1903808 ! L-tyrosine import across plasma membrane + +[Term] +id: GO:1900931 +name: positive regulation of L-tyrosine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-tyrosine import into the cell." [GOC:TermGenie] +synonym: "activation of L-tyrosine import" NARROW [GOC:TermGenie] +synonym: "activation of L-tyrosine uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-tyrosine import" BROAD [] +synonym: "positive regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "up regulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +synonym: "upregulation of L-tyrosine import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-tyrosine uptake" RELATED [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1900929 ! regulation of L-tyrosine import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:1903808 ! L-tyrosine import across plasma membrane + +[Term] +id: GO:1900932 +name: regulation of nonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900876 ! nonadec-1-ene metabolic process + +[Term] +id: GO:1900933 +name: negative regulation of nonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process +relationship: negatively_regulates GO:1900876 ! nonadec-1-ene metabolic process + +[Term] +id: GO:1900934 +name: positive regulation of nonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of nonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process +relationship: positively_regulates GO:1900876 ! nonadec-1-ene metabolic process + +[Term] +id: GO:1900935 +name: regulation of nonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900932 ! regulation of nonadec-1-ene metabolic process +relationship: regulates GO:1900877 ! nonadec-1-ene biosynthetic process + +[Term] +id: GO:1900936 +name: negative regulation of nonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "downregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "inhibition of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900933 ! negative regulation of nonadec-1-ene metabolic process +is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process +relationship: negatively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process + +[Term] +id: GO:1900937 +name: positive regulation of nonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "activation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of nonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "activation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "upregulation of nonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900934 ! positive regulation of nonadec-1-ene metabolic process +is_a: GO:1900935 ! regulation of nonadec-1-ene biosynthetic process +relationship: positively_regulates GO:1900877 ! nonadec-1-ene biosynthetic process + +[Term] +id: GO:1900938 +name: regulation of (Z)-nonadeca-1,14-diene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process + +[Term] +id: GO:1900939 +name: negative regulation of (Z)-nonadeca-1,14-diene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process +relationship: negatively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process + +[Term] +id: GO:1900940 +name: positive regulation of (Z)-nonadeca-1,14-diene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene metabolism" EXACT [GOC:TermGenie] +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process +relationship: positively_regulates GO:1900878 ! (Z)-nonadeca-1,14-diene metabolic process + +[Term] +id: GO:1900941 +name: regulation of (Z)-nonadeca-1,14-diene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900938 ! regulation of (Z)-nonadeca-1,14-diene metabolic process +relationship: regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process + +[Term] +id: GO:1900942 +name: negative regulation of (Z)-nonadeca-1,14-diene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "down regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "downregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie] +synonym: "inhibition of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900939 ! negative regulation of (Z)-nonadeca-1,14-diene metabolic process +is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process +relationship: negatively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process + +[Term] +id: GO:1900943 +name: positive regulation of (Z)-nonadeca-1,14-diene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of (Z)-nonadeca-1,14-diene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene anabolism" NARROW [GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene formation" NARROW [GOC:TermGenie] +synonym: "activation of (Z)-nonadeca-1,14-diene synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "up regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene formation" EXACT [GOC:TermGenie] +synonym: "upregulation of (Z)-nonadeca-1,14-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900940 ! positive regulation of (Z)-nonadeca-1,14-diene metabolic process +is_a: GO:1900941 ! regulation of (Z)-nonadeca-1,14-diene biosynthetic process +relationship: positively_regulates GO:1900879 ! (Z)-nonadeca-1,14-diene biosynthetic process + +[Term] +id: GO:1900944 +name: regulation of isoprene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of isoprene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:0043611 ! isoprene metabolic process + +[Term] +id: GO:1900945 +name: negative regulation of isoprene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of hemiterpene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hemiterpene metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of isoprene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of isoprene metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoprene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900944 ! regulation of isoprene metabolic process +relationship: negatively_regulates GO:0043611 ! isoprene metabolic process + +[Term] +id: GO:1900946 +name: positive regulation of isoprene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isoprene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 2-methyl-1,3-butadiene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of 2-methyl-1,3-butadiene metabolism" NARROW [GOC:TermGenie] +synonym: "activation of hemiterpene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of hemiterpene metabolism" NARROW [GOC:TermGenie] +synonym: "activation of isoprene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of isoprene metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoprene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 2-methyl-1,3-butadiene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 2-methyl-1,3-butadiene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of hemiterpene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hemiterpene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of isoprene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of isoprene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900944 ! regulation of isoprene metabolic process +relationship: positively_regulates GO:0043611 ! isoprene metabolic process + +[Term] +id: GO:1900947 +name: regulation of isoprene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900944 ! regulation of isoprene metabolic process +relationship: regulates GO:0043612 ! isoprene biosynthetic process + +[Term] +id: GO:1900948 +name: negative regulation of isoprene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hemiterpene biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hemiterpene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of isoprene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900945 ! negative regulation of isoprene metabolic process +is_a: GO:1900947 ! regulation of isoprene biosynthetic process +relationship: negatively_regulates GO:0043612 ! isoprene biosynthetic process + +[Term] +id: GO:1900949 +name: positive regulation of isoprene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 2-methyl-1,3-butadiene biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of 2-methyl-1,3-butadiene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of hemiterpene biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of hemiterpene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of isoprene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 2-methyl-1,3-butadiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 2-methyl-1,3-butadiene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hemiterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hemiterpene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of isoprene biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900946 ! positive regulation of isoprene metabolic process +is_a: GO:1900947 ! regulation of isoprene biosynthetic process +relationship: positively_regulates GO:0043612 ! isoprene biosynthetic process + +[Term] +id: GO:1900950 +name: regulation of 18-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process +relationship: regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900951 +name: negative regulation of 18-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process +is_a: GO:1900954 ! negative regulation of 18-methylnonadec-1-ene metabolic process +relationship: negatively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900952 +name: positive regulation of 18-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900950 ! regulation of 18-methylnonadec-1-ene biosynthetic process +is_a: GO:1900955 ! positive regulation of 18-methylnonadec-1-ene metabolic process +relationship: positively_regulates GO:1900881 ! 18-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900953 +name: regulation of 18-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900954 +name: negative regulation of 18-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process +relationship: negatively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900955 +name: positive regulation of 18-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 18-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900953 ! regulation of 18-methylnonadec-1-ene metabolic process +relationship: positively_regulates GO:1900880 ! 18-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900956 +name: regulation of 17-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900911 ! regulation of olefin biosynthetic process +is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process +relationship: regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900957 +name: negative regulation of 17-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900912 ! negative regulation of olefin biosynthetic process +is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process +is_a: GO:1900960 ! negative regulation of 17-methylnonadec-1-ene metabolic process +relationship: negatively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900958 +name: positive regulation of 17-methylnonadec-1-ene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene formation" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900913 ! positive regulation of olefin biosynthetic process +is_a: GO:1900956 ! regulation of 17-methylnonadec-1-ene biosynthetic process +is_a: GO:1900961 ! positive regulation of 17-methylnonadec-1-ene metabolic process +relationship: positively_regulates GO:1900883 ! 17-methylnonadec-1-ene biosynthetic process + +[Term] +id: GO:1900959 +name: regulation of 17-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:1900908 ! regulation of olefin metabolic process +relationship: regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900960 +name: negative regulation of 17-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1900909 ! negative regulation of olefin metabolic process +is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process +relationship: negatively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900961 +name: positive regulation of 17-methylnonadec-1-ene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 17-methylnonadec-1-ene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1900910 ! positive regulation of olefin metabolic process +is_a: GO:1900959 ! regulation of 17-methylnonadec-1-ene metabolic process +relationship: positively_regulates GO:1900882 ! 17-methylnonadec-1-ene metabolic process + +[Term] +id: GO:1900962 +name: regulation of methanophenazine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900965 ! regulation of methanophenazine metabolic process +relationship: regulates GO:1900630 ! methanophenazine biosynthetic process + +[Term] +id: GO:1900963 +name: negative regulation of methanophenazine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of methanophenazine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "inhibition of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process +is_a: GO:1900966 ! negative regulation of methanophenazine metabolic process +relationship: negatively_regulates GO:1900630 ! methanophenazine biosynthetic process + +[Term] +id: GO:1900964 +name: positive regulation of methanophenazine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methanophenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "activation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of methanophenazine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "activation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900962 ! regulation of methanophenazine biosynthetic process +is_a: GO:1900967 ! positive regulation of methanophenazine metabolic process +relationship: positively_regulates GO:1900630 ! methanophenazine biosynthetic process + +[Term] +id: GO:1900965 +name: regulation of methanophenazine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:1900629 ! methanophenazine metabolic process + +[Term] +id: GO:1900966 +name: negative regulation of methanophenazine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of methanophenazine metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900965 ! regulation of methanophenazine metabolic process +relationship: negatively_regulates GO:1900629 ! methanophenazine metabolic process + +[Term] +id: GO:1900967 +name: positive regulation of methanophenazine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methanophenazine metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methanophenazine metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methanophenazine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900965 ! regulation of methanophenazine metabolic process +relationship: positively_regulates GO:1900629 ! methanophenazine metabolic process + +[Term] +id: GO:1900968 +name: regulation of sarcinapterin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019220 ! regulation of phosphate metabolic process +is_a: GO:0042068 ! regulation of pteridine metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:1900867 ! sarcinapterin metabolic process + +[Term] +id: GO:1900969 +name: negative regulation of sarcinapterin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of sarcinapterin metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045863 ! negative regulation of pteridine metabolic process +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900968 ! regulation of sarcinapterin metabolic process +relationship: negatively_regulates GO:1900867 ! sarcinapterin metabolic process + +[Term] +id: GO:1900970 +name: positive regulation of sarcinapterin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of sarcinapterin metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045864 ! positive regulation of pteridine metabolic process +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900968 ! regulation of sarcinapterin metabolic process +relationship: positively_regulates GO:1900867 ! sarcinapterin metabolic process + +[Term] +id: GO:1900971 +name: regulation of sarcinapterin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900968 ! regulation of sarcinapterin metabolic process +relationship: regulates GO:1900868 ! sarcinapterin biosynthetic process + +[Term] +id: GO:1900972 +name: negative regulation of sarcinapterin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900969 ! negative regulation of sarcinapterin metabolic process +is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process +relationship: negatively_regulates GO:1900868 ! sarcinapterin biosynthetic process + +[Term] +id: GO:1900973 +name: positive regulation of sarcinapterin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sarcinapterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of sarcinapterin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "activation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of sarcinapterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900970 ! positive regulation of sarcinapterin metabolic process +is_a: GO:1900971 ! regulation of sarcinapterin biosynthetic process +relationship: positively_regulates GO:1900868 ! sarcinapterin biosynthetic process + +[Term] +id: GO:1900974 +name: regulation of tatiopterin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900977 ! regulation of tatiopterin metabolic process +relationship: regulates GO:1900870 ! tatiopterin biosynthetic process + +[Term] +id: GO:1900975 +name: negative regulation of tatiopterin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tatiopterin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process +is_a: GO:1900978 ! negative regulation of tatiopterin metabolic process +relationship: negatively_regulates GO:1900870 ! tatiopterin biosynthetic process + +[Term] +id: GO:1900976 +name: positive regulation of tatiopterin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tatiopterin biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of tatiopterin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "activation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900974 ! regulation of tatiopterin biosynthetic process +is_a: GO:1900979 ! positive regulation of tatiopterin metabolic process +relationship: positively_regulates GO:1900870 ! tatiopterin biosynthetic process + +[Term] +id: GO:1900977 +name: regulation of tatiopterin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0051174 ! regulation of phosphorus metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:1900869 ! tatiopterin metabolic process + +[Term] +id: GO:1900978 +name: negative regulation of tatiopterin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tatiopterin metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0010563 ! negative regulation of phosphorus metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1900977 ! regulation of tatiopterin metabolic process +relationship: negatively_regulates GO:1900869 ! tatiopterin metabolic process + +[Term] +id: GO:1900979 +name: positive regulation of tatiopterin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tatiopterin metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tatiopterin metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tatiopterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0010562 ! positive regulation of phosphorus metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1900977 ! regulation of tatiopterin metabolic process +relationship: positively_regulates GO:1900869 ! tatiopterin metabolic process + +[Term] +id: GO:1900980 +name: regulation of phenazine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0002047 ! phenazine biosynthetic process + +[Term] +id: GO:1900981 +name: negative regulation of phenazine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of phenazine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1900980 ! regulation of phenazine biosynthetic process +relationship: negatively_regulates GO:0002047 ! phenazine biosynthetic process + +[Term] +id: GO:1900982 +name: positive regulation of phenazine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phenazine biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of phenazine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of acridizine biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of acridizine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of azophenylene biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of azophenylene biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of dibenzo-p-diazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of dibenzo-p-diazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of dibenzopyrazine biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of dibenzopyrazine biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of phenazine biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1900980 ! regulation of phenazine biosynthetic process +relationship: positively_regulates GO:0002047 ! phenazine biosynthetic process + +[Term] +id: GO:1900983 +name: vindoline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] +synonym: "vindoline metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process +is_a: GO:1900619 ! acetate ester metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:1900984 +name: vindoline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] +synonym: "vindoline breakdown" EXACT [GOC:TermGenie] +synonym: "vindoline catabolism" EXACT [GOC:TermGenie] +synonym: "vindoline degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1900983 ! vindoline metabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process + +[Term] +id: GO:1900985 +name: vindoline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vindoline." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5292, UniPathway:UPA00365] +synonym: "vindoline anabolism" EXACT [GOC:TermGenie] +synonym: "vindoline biosynthesis" EXACT [GOC:TermGenie] +synonym: "vindoline formation" EXACT [GOC:TermGenie] +synonym: "vindoline synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process +is_a: GO:1900983 ! vindoline metabolic process +is_a: GO:1901378 ! organic heteropentacyclic compound biosynthetic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:1900986 +name: ajmaline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] +synonym: "ajmaline metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1900987 +name: ajmaline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] +synonym: "ajmaline breakdown" EXACT [GOC:TermGenie] +synonym: "ajmaline catabolism" EXACT [GOC:TermGenie] +synonym: "ajmaline degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:1900986 ! ajmaline metabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:1900988 +name: ajmaline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ajmaline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00310] +synonym: "ajmaline anabolism" EXACT [GOC:TermGenie] +synonym: "ajmaline biosynthesis" EXACT [GOC:TermGenie] +synonym: "ajmaline formation" EXACT [GOC:TermGenie] +synonym: "ajmaline synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009709 ! terpenoid indole alkaloid biosynthetic process +is_a: GO:1900986 ! ajmaline metabolic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:1900989 +name: scopolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] +synonym: "scopolamine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046448 ! tropane alkaloid metabolic process +is_a: GO:0097176 ! epoxide metabolic process + +[Term] +id: GO:1900990 +name: scopolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] +synonym: "scopolamine breakdown" EXACT [GOC:TermGenie] +synonym: "scopolamine catabolism" EXACT [GOC:TermGenie] +synonym: "scopolamine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1900989 ! scopolamine metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1900991 +name: scopolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of scopolamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00725] +synonym: "scopolamine anabolism" EXACT [GOC:TermGenie] +synonym: "scopolamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "scopolamine formation" EXACT [GOC:TermGenie] +synonym: "scopolamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009710 ! tropane alkaloid biosynthetic process +is_a: GO:1900989 ! scopolamine metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1900992 +name: (-)-secologanin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] +synonym: "(-)-secologanin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006081 ! cellular aldehyde metabolic process +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1900993 +name: (-)-secologanin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] +synonym: "(-)-secologanin breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-secologanin catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-secologanin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016100 ! monoterpenoid catabolic process +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1900992 ! (-)-secologanin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901805 ! beta-glucoside catabolic process + +[Term] +id: GO:1900994 +name: (-)-secologanin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-secologanin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00328] +synonym: "(-)-secologanin anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-secologanin biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-secologanin formation" EXACT [GOC:TermGenie] +synonym: "(-)-secologanin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016099 ! monoterpenoid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1900992 ! (-)-secologanin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:1900995 +name: ubiquinone-6 binding +namespace: molecular_function +def: "Binding to ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie] +is_a: GO:0048039 ! ubiquinone binding + +[Term] +id: GO:1900996 +name: benzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272] +synonym: "benzene breakdown" EXACT [GOC:TermGenie] +synonym: "benzene catabolism" EXACT [GOC:TermGenie] +synonym: "benzene degradation" EXACT [GOC:TermGenie] +is_a: GO:0018910 ! benzene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900997 +name: benzene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of benzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00272] +synonym: "benzene anabolism" EXACT [GOC:TermGenie] +synonym: "benzene biosynthesis" EXACT [GOC:TermGenie] +synonym: "benzene formation" EXACT [GOC:TermGenie] +synonym: "benzene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018910 ! benzene metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0120251 ! hydrocarbon biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1900998 +name: nitrobenzene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923] +synonym: "nitrobenzene breakdown" EXACT [GOC:TermGenie] +synonym: "nitrobenzene catabolism" EXACT [GOC:TermGenie] +synonym: "nitrobenzene degradation" EXACT [GOC:TermGenie] +is_a: GO:0018916 ! nitrobenzene metabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1900999 +name: nitrobenzene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nitrobenzene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00923] +synonym: "nitrobenzene anabolism" EXACT [GOC:TermGenie] +synonym: "nitrobenzene biosynthesis" EXACT [GOC:TermGenie] +synonym: "nitrobenzene formation" EXACT [GOC:TermGenie] +synonym: "nitrobenzene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018916 ! nitrobenzene metabolic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1901000 +name: regulation of response to salt stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] +synonym: "regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "regulation of salinity response" EXACT [GOC:TermGenie] +is_a: GO:0047484 ! regulation of response to osmotic stress +relationship: regulates GO:0009651 ! response to salt stress + +[Term] +id: GO:1901001 +name: negative regulation of response to salt stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] +synonym: "down regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "down regulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "down regulation of salinity response" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of salinity response" EXACT [GOC:TermGenie] +synonym: "downregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "downregulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "downregulation of salinity response" EXACT [GOC:TermGenie] +synonym: "inhibition of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "inhibition of response to salt stress" NARROW [GOC:TermGenie] +synonym: "inhibition of salinity response" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of salinity response" EXACT [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901000 ! regulation of response to salt stress +relationship: negatively_regulates GO:0009651 ! response to salt stress + +[Term] +id: GO:1901002 +name: positive regulation of response to salt stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to salt stress." [GOC:TermGenie, PMID:22627139] +synonym: "activation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "activation of response to salt stress" NARROW [GOC:TermGenie] +synonym: "activation of salinity response" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of salinity response" EXACT [GOC:TermGenie] +synonym: "up regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "up regulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "up regulation of salinity response" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of salinity response" EXACT [GOC:TermGenie] +synonym: "upregulation of response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "upregulation of response to salt stress" EXACT [GOC:TermGenie] +synonym: "upregulation of salinity response" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901000 ! regulation of response to salt stress +relationship: positively_regulates GO:0009651 ! response to salt stress + +[Term] +id: GO:1901003 +name: negative regulation of fermentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fermentation." [GOC:TermGenie] +synonym: "down regulation of fermentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of fermentation" EXACT [GOC:TermGenie] +synonym: "downregulation of fermentation" EXACT [GOC:TermGenie] +synonym: "inhibition of fermentation" NARROW [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0043465 ! regulation of fermentation +relationship: negatively_regulates GO:0006113 ! fermentation + +[Term] +id: GO:1901004 +name: ubiquinone-6 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ubiquinone-6. Ubiquinone-6 is a ubiquinone compound having a (2E,6E,10E,14E,18E)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl substituent at position 2." [GOC:al, GOC:TermGenie, PMID:1409592] +synonym: "coenzyme Q6 metabolic process" EXACT [CHEBI:52971] +synonym: "coenzyme Q6 metabolism" EXACT [CHEBI:52971] +synonym: "ubiquinone-6 metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006743 ! ubiquinone metabolic process + +[Term] +id: GO:1901005 +name: ubiquinone-6 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone-6." [GOC:TermGenie] +synonym: "ubiquinone-6 breakdown" EXACT [GOC:TermGenie] +synonym: "ubiquinone-6 catabolism" EXACT [GOC:TermGenie] +synonym: "ubiquinone-6 degradation" EXACT [GOC:TermGenie] +is_a: GO:0032322 ! ubiquinone catabolic process +is_a: GO:1901004 ! ubiquinone-6 metabolic process + +[Term] +id: GO:1901006 +name: ubiquinone-6 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ubiquinone-6." [GOC:TermGenie] +synonym: "ubiquinone-6 anabolism" EXACT [GOC:TermGenie] +synonym: "ubiquinone-6 biosynthesis" EXACT [GOC:TermGenie] +synonym: "ubiquinone-6 formation" EXACT [GOC:TermGenie] +synonym: "ubiquinone-6 synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006744 ! ubiquinone biosynthetic process +is_a: GO:1901004 ! ubiquinone-6 metabolic process + +[Term] +id: GO:1901007 +name: (S)-scoulerine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] +synonym: "(S)-scoulerine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process + +[Term] +id: GO:1901008 +name: (S)-scoulerine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] +synonym: "(S)-scoulerine breakdown" EXACT [GOC:TermGenie] +synonym: "(S)-scoulerine catabolism" EXACT [GOC:TermGenie] +synonym: "(S)-scoulerine degradation" EXACT [GOC:TermGenie] +is_a: GO:0071274 ! isoquinoline alkaloid catabolic process +is_a: GO:1901007 ! (S)-scoulerine metabolic process + +[Term] +id: GO:1901009 +name: (S)-scoulerine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (S)-scoulerine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00319] +synonym: "(S)-scoulerine anabolism" EXACT [GOC:TermGenie] +synonym: "(S)-scoulerine biosynthesis" EXACT [GOC:TermGenie] +synonym: "(S)-scoulerine formation" EXACT [GOC:TermGenie] +synonym: "(S)-scoulerine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process +is_a: GO:1901007 ! (S)-scoulerine metabolic process + +[Term] +id: GO:1901010 +name: (S)-reticuline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] +synonym: "(S)-reticuline metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process + +[Term] +id: GO:1901011 +name: (S)-reticuline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] +synonym: "(S)-reticuline breakdown" EXACT [GOC:TermGenie] +synonym: "(S)-reticuline catabolism" EXACT [GOC:TermGenie] +synonym: "(S)-reticuline degradation" EXACT [GOC:TermGenie] +is_a: GO:0071274 ! isoquinoline alkaloid catabolic process +is_a: GO:1901010 ! (S)-reticuline metabolic process + +[Term] +id: GO:1901012 +name: (S)-reticuline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (S)-reticuline." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00306] +synonym: "(S)-reticuline anabolism" EXACT [GOC:TermGenie] +synonym: "(S)-reticuline biosynthesis" EXACT [GOC:TermGenie] +synonym: "(S)-reticuline formation" EXACT [GOC:TermGenie] +synonym: "(S)-reticuline synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009708 ! benzyl isoquinoline alkaloid biosynthetic process +is_a: GO:1901010 ! (S)-reticuline metabolic process + +[Term] +id: GO:1901013 +name: 3alpha(S)-strictosidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] +synonym: "3alpha(S)-strictosidine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035834 ! indole alkaloid metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1901014 +name: 3alpha(S)-strictosidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] +synonym: "3alpha(S)-strictosidine breakdown" EXACT [GOC:TermGenie] +synonym: "3alpha(S)-strictosidine catabolism" EXACT [GOC:TermGenie] +synonym: "3alpha(S)-strictosidine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process +is_a: GO:1901805 ! beta-glucoside catabolic process + +[Term] +id: GO:1901015 +name: 3alpha(S)-strictosidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3alpha(S)-strictosidine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00311] +synonym: "3alpha(S)-strictosidine anabolism" EXACT [GOC:TermGenie] +synonym: "3alpha(S)-strictosidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "3alpha(S)-strictosidine formation" EXACT [GOC:TermGenie] +synonym: "3alpha(S)-strictosidine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:1901013 ! 3alpha(S)-strictosidine metabolic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process + +[Term] +id: GO:1901016 +name: regulation of potassium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of potassium transporter activity" EXACT [GOC:TermGenie] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1901379 ! regulation of potassium ion transmembrane transport + +[Term] +id: GO:1901017 +name: negative regulation of potassium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "down regulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "inhibition of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie] +synonym: "inhibition of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of potassium transporter activity" EXACT [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport + +[Term] +id: GO:1901018 +name: positive regulation of potassium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +synonym: "activation of potassium ion transmembrane transporter activity" NARROW [GOC:TermGenie] +synonym: "activation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "up regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "up regulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium transporter activity" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium transporter activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport + +[Term] +id: GO:1901019 +name: regulation of calcium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport + +[Term] +id: GO:1901020 +name: negative regulation of calcium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport + +[Term] +id: GO:1901021 +name: positive regulation of calcium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity." [GOC:BHF, GOC:TermGenie] +synonym: "activation of calcium ion transmembrane transporter activity" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion transmembrane transporter activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport + +[Term] +id: GO:1901022 +name: 4-hydroxyphenylacetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] +synonym: "4-hydroxyphenylacetate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:1901023 +name: 4-hydroxyphenylacetate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] +synonym: "4-hydroxyphenylacetate breakdown" EXACT [GOC:TermGenie] +synonym: "4-hydroxyphenylacetate catabolism" EXACT [GOC:TermGenie] +synonym: "4-hydroxyphenylacetate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process + +[Term] +id: GO:1901024 +name: 4-hydroxyphenylacetate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyphenylacetate." [GOC:TermGenie, GOC:yaf, MetaCyc:RXN-8505, UniPathway:UPA00208] +synonym: "4-hydroxyphenylacetate anabolism" EXACT [GOC:TermGenie] +synonym: "4-hydroxyphenylacetate biosynthesis" EXACT [GOC:TermGenie] +synonym: "4-hydroxyphenylacetate formation" EXACT [GOC:TermGenie] +synonym: "4-hydroxyphenylacetate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901022 ! 4-hydroxyphenylacetate metabolic process + +[Term] +id: GO:1901025 +name: ripoptosome assembly involved in extrinsic apoptotic signaling pathway +namespace: biological_process +def: "The aggregation, arrangement and bonding together of ripoptosome components leading to apoptosis via the extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400] +is_a: GO:0097343 ! ripoptosome assembly +relationship: part_of GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:1901026 +name: ripoptosome assembly involved in necroptotic process +namespace: biological_process +def: "The aggregation, arrangement and bonding together of ripoptosome components leading to a necroptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:22274400] +synonym: "ripoptosome assembly involved in necroptosis" NARROW [] +is_a: GO:0097343 ! ripoptosome assembly +relationship: part_of GO:0070266 ! necroptotic process + +[Term] +id: GO:1901027 +name: dextrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of dextrin." [GOC:TermGenie] +synonym: "dextrin breakdown" EXACT [GOC:TermGenie] +synonym: "dextrin catabolism" EXACT [GOC:TermGenie] +synonym: "dextrin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009251 ! glucan catabolic process + +[Term] +id: GO:1901028 +name: regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "regulation of mitochondrial outer membrane permeabilization" BROAD [] +synonym: "regulation of MOMP" EXACT [GOC:TermGenie] +is_a: GO:0010821 ! regulation of mitochondrion organization +is_a: GO:0046902 ! regulation of mitochondrial membrane permeability +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0097345 ! mitochondrial outer membrane permeabilization + +[Term] +id: GO:1901029 +name: negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] +synonym: "down regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "down regulation of MOMP" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "down-regulation of MOMP" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "downregulation of MOMP" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie] +synonym: "inhibition of MOMP" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial outer membrane permeabilization" BROAD [] +synonym: "negative regulation of MOMP" EXACT [GOC:TermGenie] +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +relationship: negatively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization + +[Term] +id: GO:1901030 +name: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie] +comment: Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID. +synonym: "activation of mitochondrial outer membrane permeabilization" NARROW [GOC:TermGenie] +synonym: "activation of MOMP" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial outer membrane permeabilization" BROAD [] +synonym: "positive regulation of MOMP" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "up regulation of MOMP" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "up-regulation of MOMP" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial outer membrane permeabilization" EXACT [GOC:TermGenie] +synonym: "upregulation of MOMP" EXACT [GOC:TermGenie] +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1901028 ! regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway +relationship: positively_regulates GO:0097345 ! mitochondrial outer membrane permeabilization + +[Term] +id: GO:1901031 +name: regulation of response to reactive oxygen species +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] +synonym: "regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "regulation of response to ROS" EXACT [GOC:TermGenie] +is_a: GO:1902882 ! regulation of response to oxidative stress +relationship: regulates GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:1901032 +name: negative regulation of response to reactive oxygen species +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] +synonym: "down regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "down regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "down regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "down regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "down regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "down regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "down regulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "downregulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "downregulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "downregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "downregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "downregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "downregulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "downregulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "inhibition of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "inhibition of response to AOS" EXACT [GOC:TermGenie] +synonym: "inhibition of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "inhibition of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "inhibition of response to reactive oxygen species" NARROW [GOC:TermGenie] +synonym: "inhibition of response to ROI" EXACT [GOC:TermGenie] +synonym: "inhibition of response to ROS" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to ROS" EXACT [GOC:TermGenie] +is_a: GO:1901031 ! regulation of response to reactive oxygen species +is_a: GO:1902883 ! negative regulation of response to oxidative stress +relationship: negatively_regulates GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:1901033 +name: positive regulation of response to reactive oxygen species +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to reactive oxygen species." [GOC:kmv, GOC:TermGenie] +synonym: "activation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "activation of response to AOS" EXACT [GOC:TermGenie] +synonym: "activation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "activation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "activation of response to reactive oxygen species" NARROW [GOC:TermGenie] +synonym: "activation of response to ROI" EXACT [GOC:TermGenie] +synonym: "activation of response to ROS" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "up regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "up regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "up regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "up regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "up regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "up regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "up regulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to ROS" EXACT [GOC:TermGenie] +synonym: "upregulation of response to active oxygen species" EXACT [GOC:TermGenie] +synonym: "upregulation of response to AOS" EXACT [GOC:TermGenie] +synonym: "upregulation of response to reactive oxidative species" EXACT [GOC:TermGenie] +synonym: "upregulation of response to reactive oxygen intermediate" EXACT [GOC:TermGenie] +synonym: "upregulation of response to reactive oxygen species" EXACT [GOC:TermGenie] +synonym: "upregulation of response to ROI" EXACT [GOC:TermGenie] +synonym: "upregulation of response to ROS" EXACT [GOC:TermGenie] +is_a: GO:1901031 ! regulation of response to reactive oxygen species +is_a: GO:1902884 ! positive regulation of response to oxidative stress +relationship: positively_regulates GO:0000302 ! response to reactive oxygen species + +[Term] +id: GO:1901034 +name: regulation of L-glutamine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie] +synonym: "regulation of L-glutamine import" BROAD [] +synonym: "regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +is_a: GO:2000485 ! regulation of glutamine transport +relationship: regulates GO:1903803 ! L-glutamine import across plasma membrane + +[Term] +id: GO:1901035 +name: negative regulation of L-glutamine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine import into a cell." [GOC:TermGenie] +synonym: "down regulation of L-glutamine import" EXACT [GOC:TermGenie] +synonym: "down regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-glutamine import" BROAD [GOC:TermGenie] +synonym: "down-regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamine import" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "inhibition of L-glutamine import" NARROW [GOC:TermGenie] +synonym: "inhibition of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-glutamine import" BROAD [] +synonym: "negative regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:2000486 ! negative regulation of glutamine transport +relationship: negatively_regulates GO:1903803 ! L-glutamine import across plasma membrane + +[Term] +id: GO:1901036 +name: positive regulation of L-glutamine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-glutamine import into cell." [GOC:TermGenie] +synonym: "activation of L-glutamine import" NARROW [GOC:TermGenie] +synonym: "activation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-glutamine import" BROAD [] +synonym: "positive regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamine import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamine uptake" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamine import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamine uptake" EXACT [GOC:TermGenie] +is_a: GO:1901034 ! regulation of L-glutamine import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:2000487 ! positive regulation of glutamine transport +relationship: positively_regulates GO:1903803 ! L-glutamine import across plasma membrane + +[Term] +id: GO:1901037 +name: obsolete regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed during the M/G1 transition of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:12411492] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "global transcription regulation from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of transcription during M/G1 transition of mitotic cell cycle" BROAD [] +synonym: "regulation of transcription from Pol II promoter during M/G1 transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter during M/G1 transition of mitotic cell cycle" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter involved in M/G1 transition of mitotic cell cycle" RELATED [] +is_obsolete: true +consider: GO:0006357 + +[Term] +id: GO:1901038 +name: cyanidin 3-O-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside." [GOC:TermGenie, PMID:21899608] +synonym: "cyanidin 3-O-beta-D-glucoside metabolic process" EXACT [] +synonym: "cyanidin 3-O-beta-D-glucoside metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009812 ! flavonoid metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1901039 +name: regulation of peptide antigen transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie] +is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen +is_a: GO:0090087 ! regulation of peptide transport +relationship: regulates GO:0046968 ! peptide antigen transport + +[Term] +id: GO:1901040 +name: negative regulation of peptide antigen transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie, PMID:16691491] +synonym: "down regulation of peptide antigen transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptide antigen transport" EXACT [GOC:TermGenie] +synonym: "downregulation of peptide antigen transport" EXACT [GOC:TermGenie] +synonym: "inhibition of peptide antigen transport" NARROW [GOC:TermGenie] +is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1901039 ! regulation of peptide antigen transport +relationship: negatively_regulates GO:0046968 ! peptide antigen transport + +[Term] +id: GO:1901041 +name: positive regulation of peptide antigen transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptide antigen transport." [GOC:bf, GOC:TermGenie] +synonym: "activation of peptide antigen transport" NARROW [GOC:TermGenie] +synonym: "up regulation of peptide antigen transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptide antigen transport" EXACT [GOC:TermGenie] +synonym: "upregulation of peptide antigen transport" EXACT [GOC:TermGenie] +is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1901039 ! regulation of peptide antigen transport +relationship: positively_regulates GO:0046968 ! peptide antigen transport + +[Term] +id: GO:1901043 +name: obsolete protein polyubiquitination involved in cellular response to misfolded protein +namespace: biological_process +def: "OBSOLETE. Any protein polyubiquitination that is involved in cellular response to misfolded protein." [GOC:al, GOC:TermGenie, PMID:21324894] +comment: This term was made obsolete because it was added in error and a more specific term was created. +synonym: "polyubiquitin of cellular response to misfolded protein" RELATED [GOC:TermGenie] +synonym: "protein polyubiquitination involved in cellular response to misfolded protein" EXACT [] +synonym: "protein polyubiquitination of cellular response to misfolded protein" EXACT [GOC:TermGenie] +synonym: "protein polyubiquitinylation of cellular response to misfolded protein" EXACT [GOC:TermGenie] +synonym: "protein polyubiquitylation of cellular response to misfolded protein" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:1901044 + +[Term] +id: GO:1901044 +name: protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any protein polyubiquitination that is involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process." [GOC:al, GOC:TermGenie, PMID:21324894] +is_a: GO:0000209 ! protein polyubiquitination +relationship: part_of GO:0071630 ! nuclear protein quality control by the ubiquitin-proteasome system + +[Term] +id: GO:1901045 +name: negative regulation of oviposition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie] +synonym: "down regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "down regulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "down regulation of oviposition" EXACT [GOC:TermGenie] +synonym: "down-regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "down-regulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "down-regulation of oviposition" EXACT [GOC:TermGenie] +synonym: "downregulation of egg laying" BROAD [GOC:TermGenie] +synonym: "downregulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "downregulation of oviposition" EXACT [GOC:TermGenie] +synonym: "inhibition of egg laying" BROAD [GOC:TermGenie] +synonym: "inhibition of egg-laying" BROAD [GOC:TermGenie] +synonym: "inhibition of oviposition" NARROW [GOC:TermGenie] +synonym: "negative regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "negative regulation of egg-laying" BROAD [GOC:TermGenie] +is_a: GO:0046662 ! regulation of oviposition +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0018991 ! oviposition + +[Term] +id: GO:1901046 +name: positive regulation of oviposition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oviposition." [GOC:kmv, GOC:TermGenie] +synonym: "activation of egg laying" BROAD [GOC:TermGenie] +synonym: "activation of egg-laying" BROAD [GOC:TermGenie] +synonym: "activation of oviposition" NARROW [GOC:TermGenie] +synonym: "positive regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "positive regulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "up regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "up regulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "up regulation of oviposition" EXACT [GOC:TermGenie] +synonym: "up-regulation of egg laying" BROAD [GOC:TermGenie] +synonym: "up-regulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "up-regulation of oviposition" EXACT [GOC:TermGenie] +synonym: "upregulation of egg laying" BROAD [GOC:TermGenie] +synonym: "upregulation of egg-laying" BROAD [GOC:TermGenie] +synonym: "upregulation of oviposition" EXACT [GOC:TermGenie] +is_a: GO:0046662 ! regulation of oviposition +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0018991 ! oviposition + +[Term] +id: GO:1901047 +name: insulin receptor signaling pathway involved in determination of adult lifespan +namespace: biological_process +def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin that controls viability and duration in the adult phase of the life-cycle." [GOC:kmv, GOC:TermGenie, PMID:9360933] +synonym: "daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +is_a: GO:0008286 ! insulin receptor signaling pathway +relationship: part_of GO:0008340 ! determination of adult lifespan + +[Term] +id: GO:1901048 +name: transforming growth factor beta receptor signaling pathway involved in regulation of multicellular organism growth +namespace: biological_process +def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription, that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:kmv, GOC:TermGenie, PMID:9847239] +synonym: "TGF-beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signaling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signaling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signaling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway of regulation of body growth" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway of regulation of body size" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway of regulation of multicellular organism growth" EXACT [GOC:TermGenie] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +relationship: part_of GO:0040014 ! regulation of multicellular organism growth + +[Term] +id: GO:1901049 +name: atropine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] +synonym: "atropine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046448 ! tropane alkaloid metabolic process + +[Term] +id: GO:1901050 +name: atropine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] +synonym: "atropine breakdown" EXACT [GOC:TermGenie] +synonym: "atropine catabolism" EXACT [GOC:TermGenie] +synonym: "atropine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901049 ! atropine metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1901051 +name: atropine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of atropine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00303] +synonym: "atropine anabolism" EXACT [GOC:TermGenie] +synonym: "atropine biosynthesis" EXACT [GOC:TermGenie] +synonym: "atropine formation" EXACT [GOC:TermGenie] +synonym: "atropine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009710 ! tropane alkaloid biosynthetic process +is_a: GO:1901049 ! atropine metabolic process + +[Term] +id: GO:1901052 +name: sarcosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] +synonym: "sarcosine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1901053 +name: sarcosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] +synonym: "sarcosine breakdown" EXACT [GOC:TermGenie] +synonym: "sarcosine catabolism" EXACT [GOC:TermGenie] +synonym: "sarcosine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:1901052 ! sarcosine metabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process + +[Term] +id: GO:1901054 +name: sarcosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sarcosine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00292] +synonym: "sarcosine anabolism" EXACT [GOC:TermGenie] +synonym: "sarcosine biosynthesis" EXACT [GOC:TermGenie] +synonym: "sarcosine formation" EXACT [GOC:TermGenie] +synonym: "sarcosine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:1901052 ! sarcosine metabolic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process + +[Term] +id: GO:1901055 +name: trimethylenediamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] +synonym: "trimethylenediamine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:1901056 +name: trimethylenediamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] +synonym: "trimethylenediamine breakdown" EXACT [GOC:TermGenie] +synonym: "trimethylenediamine catabolism" EXACT [GOC:TermGenie] +synonym: "trimethylenediamine degradation" EXACT [GOC:TermGenie] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:1901055 ! trimethylenediamine metabolic process + +[Term] +id: GO:1901057 +name: trimethylenediamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of trimethylenediamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00010] +synonym: "trimethylenediamine anabolism" EXACT [GOC:TermGenie] +synonym: "trimethylenediamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "trimethylenediamine formation" EXACT [GOC:TermGenie] +synonym: "trimethylenediamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:1901055 ! trimethylenediamine metabolic process + +[Term] +id: GO:1901058 +name: p-hydroxyphenyl lignin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "H-lignin metabolic process" EXACT [GOC:mengo_curators] +synonym: "p-hydroxyphenyl lignin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009808 ! lignin metabolic process + +[Term] +id: GO:1901059 +name: p-hydroxyphenyl lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "H-lignin catabolic process" EXACT [GOC:mengo_curators] +synonym: "p-hydroxyphenyl lignin breakdown" EXACT [GOC:TermGenie] +synonym: "p-hydroxyphenyl lignin catabolism" EXACT [GOC:TermGenie] +synonym: "p-hydroxyphenyl lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0046274 ! lignin catabolic process +is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process + +[Term] +id: GO:1901060 +name: p-hydroxyphenyl lignin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "H-lignin biosynthetic process" EXACT [GOC:mengo_curators] +synonym: "p-hydroxyphenyl lignin anabolism" EXACT [GOC:TermGenie] +synonym: "p-hydroxyphenyl lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "p-hydroxyphenyl lignin formation" EXACT [GOC:TermGenie] +synonym: "p-hydroxyphenyl lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009809 ! lignin biosynthetic process +is_a: GO:1901058 ! p-hydroxyphenyl lignin metabolic process + +[Term] +id: GO:1901061 +name: guaiacyl lignin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "G-lignin metabolic process" EXACT [GOC:mengo_curators] +synonym: "guaiacyl lignin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009808 ! lignin metabolic process + +[Term] +id: GO:1901062 +name: guaiacyl lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "G-lignin catabolic process" EXACT [GOC:mengo_curators] +synonym: "guaiacyl lignin breakdown" EXACT [GOC:TermGenie] +synonym: "guaiacyl lignin catabolism" EXACT [GOC:TermGenie] +synonym: "guaiacyl lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0046274 ! lignin catabolic process +is_a: GO:1901061 ! guaiacyl lignin metabolic process + +[Term] +id: GO:1901063 +name: guaiacyl lignin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guaiacyl lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "G-lignin biosynthetic process" EXACT [GOC:mengo_curators] +synonym: "guaiacyl lignin anabolism" EXACT [GOC:TermGenie] +synonym: "guaiacyl lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "guaiacyl lignin formation" EXACT [GOC:TermGenie] +synonym: "guaiacyl lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009809 ! lignin biosynthetic process +is_a: GO:1901061 ! guaiacyl lignin metabolic process + +[Term] +id: GO:1901064 +name: syringal lignin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving syringal lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "S-lignin metabolic process" EXACT [GOC:mengo_curators] +synonym: "syringal lignin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009808 ! lignin metabolic process + +[Term] +id: GO:1901065 +name: syringal lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of syringal lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "S-lignin catabolic process" EXACT [GOC:mengo_curators] +synonym: "syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "syringal lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0046274 ! lignin catabolic process +is_a: GO:1901064 ! syringal lignin metabolic process + +[Term] +id: GO:1901066 +name: syringal lignin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of syringal lignin." [GOC:mengo_curators, GOC:TermGenie] +synonym: "S-lignin biosynthetic process" EXACT [GOC:mengo_curators] +synonym: "syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "syringal lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009809 ! lignin biosynthetic process +is_a: GO:1901064 ! syringal lignin metabolic process + +[Term] +id: GO:1901067 +name: ferulate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ferulate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "ferulate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0033494 ! ferulate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1901068 +name: guanosine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving guanosine-containing compounds (guanosines)." [GOC:TermGenie] +synonym: "guanosine-containing compound metabolism" EXACT [GOC:bf] +synonym: "guanosines metabolic process" EXACT [CHEBI:24458] +synonym: "guanosines metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:1901069 +name: guanosine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines)." [GOC:TermGenie] +synonym: "guanosine-containing compound breakdown" EXACT [GOC:bf] +synonym: "guanosine-containing compound catabolism" EXACT [GOC:bf] +synonym: "guanosine-containing compound degradation" EXACT [GOC:bf] +synonym: "guanosines breakdown" EXACT [GOC:TermGenie] +synonym: "guanosines catabolic process" EXACT [CHEBI:24458] +synonym: "guanosines catabolism" EXACT [GOC:TermGenie] +synonym: "guanosines degradation" EXACT [GOC:TermGenie] +is_a: GO:0046130 ! purine ribonucleoside catabolic process +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:1901070 +name: guanosine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of guanosine-containing compounds (guanosines)." [GOC:TermGenie] +synonym: "guanosine-containing compound anabolism" EXACT [GOC:bf] +synonym: "guanosine-containing compound biosynthesis" EXACT [GOC:bf] +synonym: "guanosine-containing compound formation" EXACT [GOC:bf] +synonym: "guanosine-containing compound synthesis" EXACT [GOC:bf] +synonym: "guanosines anabolism" EXACT [GOC:TermGenie] +synonym: "guanosines biosynthesis" EXACT [GOC:TermGenie] +synonym: "guanosines biosynthetic process" EXACT [CHEBI:24458] +synonym: "guanosines formation" EXACT [GOC:TermGenie] +synonym: "guanosines synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process +is_a: GO:1901068 ! guanosine-containing compound metabolic process + +[Term] +id: GO:1901071 +name: glucosamine-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] +synonym: "glucosamine-containing compound metabolism" EXACT [GOC:bf] +synonym: "glucosamines metabolic process" EXACT [CHEBI:24271] +synonym: "glucosamines metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006040 ! amino sugar metabolic process + +[Term] +id: GO:1901072 +name: glucosamine-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] +synonym: "glucosamine-containing compound breakdown" EXACT [GOC:bf] +synonym: "glucosamine-containing compound catabolism" EXACT [GOC:bf] +synonym: "glucosamine-containing compound degradation" EXACT [GOC:bf] +synonym: "glucosamines breakdown" EXACT [GOC:TermGenie] +synonym: "glucosamines catabolic process" EXACT [CHEBI:24271] +synonym: "glucosamines catabolism" EXACT [GOC:TermGenie] +synonym: "glucosamines degradation" EXACT [GOC:TermGenie] +is_a: GO:0046348 ! amino sugar catabolic process +is_a: GO:1901071 ! glucosamine-containing compound metabolic process + +[Term] +id: GO:1901073 +name: glucosamine-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glucosamine-containing compounds (glucosamines)." [GOC:TermGenie] +synonym: "glucosamine-containing compound anabolism" EXACT [GOC:bf] +synonym: "glucosamine-containing compound biosynthesis" EXACT [GOC:bf] +synonym: "glucosamine-containing compound formation" EXACT [GOC:bf] +synonym: "glucosamine-containing compound synthesis" EXACT [GOC:bf] +synonym: "glucosamines anabolism" EXACT [GOC:TermGenie] +synonym: "glucosamines biosynthesis" EXACT [GOC:TermGenie] +synonym: "glucosamines biosynthetic process" EXACT [CHEBI:24271] +synonym: "glucosamines formation" EXACT [GOC:TermGenie] +synonym: "glucosamines synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046349 ! amino sugar biosynthetic process +is_a: GO:1901071 ! glucosamine-containing compound metabolic process + +[Term] +id: GO:1901074 +name: regulation of engulfment of apoptotic cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] +synonym: "regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +is_a: GO:0060099 ! regulation of phagocytosis, engulfment +relationship: regulates GO:0043652 ! engulfment of apoptotic cell + +[Term] +id: GO:1901075 +name: negative regulation of engulfment of apoptotic cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] +synonym: "down regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "down regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "down regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "down-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "down-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "downregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "downregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "downregulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "inhibition of engulfment of apoptotic cell" NARROW [GOC:TermGenie] +synonym: "inhibition of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie] +synonym: "inhibition of engulfment of cell corpse" NARROW [GOC:TermGenie] +synonym: "negative regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "negative regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +is_a: GO:0060101 ! negative regulation of phagocytosis, engulfment +is_a: GO:1901074 ! regulation of engulfment of apoptotic cell +is_a: GO:2000426 ! negative regulation of apoptotic cell clearance +relationship: negatively_regulates GO:0043652 ! engulfment of apoptotic cell + +[Term] +id: GO:1901076 +name: positive regulation of engulfment of apoptotic cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell." [GO:kmv, GOC:TermGenie, PMID:19402756] +synonym: "activation of engulfment of apoptotic cell" NARROW [GOC:TermGenie] +synonym: "activation of engulfment of apoptotic cell corpse" NARROW [GOC:TermGenie] +synonym: "activation of engulfment of cell corpse" NARROW [GOC:TermGenie] +synonym: "positive regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "positive regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "up regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "up regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "up regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "up-regulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "up-regulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +synonym: "upregulation of engulfment of apoptotic cell" EXACT [GOC:TermGenie] +synonym: "upregulation of engulfment of apoptotic cell corpse" EXACT [GOC:TermGenie] +synonym: "upregulation of engulfment of cell corpse" EXACT [GOC:TermGenie] +is_a: GO:0060100 ! positive regulation of phagocytosis, engulfment +is_a: GO:1901074 ! regulation of engulfment of apoptotic cell +is_a: GO:2000427 ! positive regulation of apoptotic cell clearance +relationship: positively_regulates GO:0043652 ! engulfment of apoptotic cell + +[Term] +id: GO:1901077 +name: regulation of relaxation of muscle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] +is_a: GO:0090257 ! regulation of muscle system process +relationship: regulates GO:0090075 ! relaxation of muscle + +[Term] +id: GO:1901078 +name: negative regulation of relaxation of muscle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] +synonym: "down regulation of relaxation of muscle" EXACT [GOC:TermGenie] +synonym: "down-regulation of relaxation of muscle" EXACT [GOC:TermGenie] +synonym: "downregulation of relaxation of muscle" EXACT [GOC:TermGenie] +synonym: "inhibition of relaxation of muscle" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901077 ! regulation of relaxation of muscle +relationship: negatively_regulates GO:0090075 ! relaxation of muscle + +[Term] +id: GO:1901079 +name: positive regulation of relaxation of muscle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of relaxation of muscle." [GOC:TermGenie] +synonym: "activation of relaxation of muscle" NARROW [GOC:TermGenie] +synonym: "up regulation of relaxation of muscle" EXACT [GOC:TermGenie] +synonym: "up-regulation of relaxation of muscle" EXACT [GOC:TermGenie] +synonym: "upregulation of relaxation of muscle" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901077 ! regulation of relaxation of muscle +relationship: positively_regulates GO:0090075 ! relaxation of muscle + +[Term] +id: GO:1901080 +name: regulation of relaxation of smooth muscle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] +synonym: "regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +is_a: GO:1901077 ! regulation of relaxation of muscle +relationship: regulates GO:0044557 ! relaxation of smooth muscle + +[Term] +id: GO:1901081 +name: negative regulation of relaxation of smooth muscle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] +synonym: "down regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "down regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "down-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "down-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "downregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "downregulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "inhibition of relaxation of smooth muscle" NARROW [GOC:TermGenie] +synonym: "inhibition of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "negative regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +is_a: GO:1901078 ! negative regulation of relaxation of muscle +is_a: GO:1901080 ! regulation of relaxation of smooth muscle +relationship: negatively_regulates GO:0044557 ! relaxation of smooth muscle + +[Term] +id: GO:1901082 +name: positive regulation of relaxation of smooth muscle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of relaxation of smooth muscle." [GOC:TermGenie] +synonym: "activation of relaxation of smooth muscle" NARROW [GOC:TermGenie] +synonym: "activation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "positive regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "up regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "up regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "up-regulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +synonym: "upregulation of relaxation of smooth muscle" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle relaxation" EXACT [GOC:TermGenie] +is_a: GO:1901079 ! positive regulation of relaxation of muscle +is_a: GO:1901080 ! regulation of relaxation of smooth muscle +relationship: positively_regulates GO:0044557 ! relaxation of smooth muscle + +[Term] +id: GO:1901083 +name: pyrrolizidine alkaloid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] +synonym: "pyrrolizidine alkaloid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009820 ! alkaloid metabolic process + +[Term] +id: GO:1901084 +name: pyrrolizidine alkaloid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] +synonym: "pyrrolizidine alkaloid breakdown" EXACT [GOC:TermGenie] +synonym: "pyrrolizidine alkaloid catabolism" EXACT [GOC:TermGenie] +synonym: "pyrrolizidine alkaloid degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process + +[Term] +id: GO:1901085 +name: pyrrolizidine alkaloid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pyrrolizidine alkaloid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00329] +synonym: "pyrrolizidine alkaloid anabolism" EXACT [GOC:TermGenie] +synonym: "pyrrolizidine alkaloid biosynthesis" EXACT [GOC:TermGenie] +synonym: "pyrrolizidine alkaloid formation" EXACT [GOC:TermGenie] +synonym: "pyrrolizidine alkaloid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:1901083 ! pyrrolizidine alkaloid metabolic process + +[Term] +id: GO:1901086 +name: benzylpenicillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] +synonym: "benzylpenicillin metabolism" EXACT [GOC:TermGenie] +synonym: "penicillin G metabolism" EXACT [] +is_a: GO:0042316 ! penicillin metabolic process + +[Term] +id: GO:1901087 +name: benzylpenicillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] +synonym: "benzylpenicillin breakdown" EXACT [GOC:TermGenie] +synonym: "benzylpenicillin catabolism" EXACT [GOC:TermGenie] +synonym: "benzylpenicillin degradation" EXACT [GOC:TermGenie] +synonym: "penicillin G breakdown" EXACT [] +synonym: "penicillin G catabolic process" EXACT [] +synonym: "penicillin G catabolism" EXACT [] +synonym: "penicillin G degradation" EXACT [] +is_a: GO:0042317 ! penicillin catabolic process +is_a: GO:1901086 ! benzylpenicillin metabolic process + +[Term] +id: GO:1901088 +name: benzylpenicillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of benzylpenicillin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00149] +synonym: "benzylpenicillin anabolism" EXACT [GOC:TermGenie] +synonym: "benzylpenicillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "benzylpenicillin formation" EXACT [GOC:TermGenie] +synonym: "benzylpenicillin synthesis" EXACT [GOC:TermGenie] +synonym: "penicillin G anabolism" EXACT [GOC:yaf] +synonym: "penicillin G biosynthesis" EXACT [GOC:yaf] +synonym: "penicillin G formation" EXACT [GOC:yaf] +synonym: "penicillin G synthesis" EXACT [GOC:yaf] +is_a: GO:0042318 ! penicillin biosynthetic process +is_a: GO:1901086 ! benzylpenicillin metabolic process + +[Term] +id: GO:1901089 +name: acetate ester metabolic process involved in fermentation +namespace: biological_process +def: "Any acetate ester metabolic process that is involved in fermentation." [GOC:sgd_curators, GOC:TermGenie] +synonym: "acetate ester metabolic process during fermentation" EXACT [GOC:sgd_curators] +is_a: GO:1900619 ! acetate ester metabolic process +relationship: part_of GO:0006113 ! fermentation + +[Term] +id: GO:1901090 +name: regulation of protein tetramerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] +synonym: "regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of protein tetramer formation" EXACT [GOC:TermGenie] +is_a: GO:0032459 ! regulation of protein oligomerization +relationship: regulates GO:0051262 ! protein tetramerization + +[Term] +id: GO:1901091 +name: negative regulation of protein tetramerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] +synonym: "down regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein tetramerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tetramerization" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tetramerization" EXACT [GOC:TermGenie] +synonym: "inhibition of protein tetramer assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of protein tetramer biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of protein tetramer biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of protein tetramer formation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein tetramerization" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein tetramer formation" EXACT [GOC:TermGenie] +is_a: GO:0032460 ! negative regulation of protein oligomerization +is_a: GO:1901090 ! regulation of protein tetramerization +relationship: negatively_regulates GO:0051262 ! protein tetramerization + +[Term] +id: GO:1901092 +name: positive regulation of protein tetramerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein tetramerization." [GOC:pm, GOC:TermGenie] +synonym: "activation of protein tetramer assembly" NARROW [GOC:TermGenie] +synonym: "activation of protein tetramer biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of protein tetramer biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of protein tetramer formation" NARROW [GOC:TermGenie] +synonym: "activation of protein tetramerization" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tetramerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tetramerization" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tetramer assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tetramer formation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tetramerization" EXACT [GOC:TermGenie] +is_a: GO:0032461 ! positive regulation of protein oligomerization +is_a: GO:1901090 ! regulation of protein tetramerization +relationship: positively_regulates GO:0051262 ! protein tetramerization + +[Term] +id: GO:1901093 +name: regulation of protein homotetramerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] +synonym: "regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +is_a: GO:0032462 ! regulation of protein homooligomerization +is_a: GO:1901090 ! regulation of protein tetramerization +relationship: regulates GO:0051289 ! protein homotetramerization + +[Term] +id: GO:1901094 +name: negative regulation of protein homotetramerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] +synonym: "down regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein homotetramerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein homotetramerization" EXACT [GOC:TermGenie] +synonym: "downregulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein homotetramerization" EXACT [GOC:TermGenie] +synonym: "inhibition of protein homotetramer assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of protein homotetramer biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of protein homotetramer formation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein homotetramerization" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +is_a: GO:0032463 ! negative regulation of protein homooligomerization +is_a: GO:1901091 ! negative regulation of protein tetramerization +is_a: GO:1901093 ! regulation of protein homotetramerization +relationship: negatively_regulates GO:0051289 ! protein homotetramerization + +[Term] +id: GO:1901095 +name: positive regulation of protein homotetramerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein homotetramerization." [GOC:pm, GOC:TermGenie] +synonym: "activation of protein homotetramer assembly" NARROW [GOC:TermGenie] +synonym: "activation of protein homotetramer biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of protein homotetramer biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of protein homotetramer formation" NARROW [GOC:TermGenie] +synonym: "activation of protein homotetramerization" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein homotetramerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein homotetramerization" EXACT [GOC:TermGenie] +synonym: "upregulation of protein homotetramer assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of protein homotetramer biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of protein homotetramer biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of protein homotetramer formation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein homotetramerization" EXACT [GOC:TermGenie] +is_a: GO:0032464 ! positive regulation of protein homooligomerization +is_a: GO:1901092 ! positive regulation of protein tetramerization +is_a: GO:1901093 ! regulation of protein homotetramerization +relationship: positively_regulates GO:0051289 ! protein homotetramerization + +[Term] +id: GO:1901096 +name: regulation of autophagosome maturation +namespace: biological_process +alt_id: GO:1902452 +def: "Any process that modulates the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] +synonym: "regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] +synonym: "regulation of autophagosome fusion" EXACT [] +synonym: "regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +relationship: regulates GO:0097352 ! autophagosome maturation + +[Term] +id: GO:1901097 +name: negative regulation of autophagosome maturation +namespace: biological_process +alt_id: GO:1902453 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] +synonym: "down regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "down regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "down regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "down regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "down regulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "down regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "down-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "down-regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "downregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "downregulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "downregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "inhibition of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagic vacuole fusion" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagic vacuole maturation" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "negative regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] +synonym: "negative regulation of autophagosome fusion" EXACT [] +synonym: "negative regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +is_a: GO:1901096 ! regulation of autophagosome maturation +relationship: negatively_regulates GO:0097352 ! autophagosome maturation + +[Term] +id: GO:1901098 +name: positive regulation of autophagosome maturation +namespace: biological_process +alt_id: GO:1902454 +def: "Any process that activates or increases the frequency, rate or extent of autophagosome maturation." [GOC:autophagy, GOC:TermGenie, PMID:10436019, PMID:21383079] +synonym: "activation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "activation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "activation of autophagic vacuole fusion" NARROW [GOC:TermGenie] +synonym: "activation of autophagic vacuole maturation" NARROW [GOC:TermGenie] +synonym: "activation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "activation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "positive regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of autophagic vacuole fusion" EXACT [GOC:autophagy] +synonym: "positive regulation of autophagosome fusion" EXACT [] +synonym: "positive regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "up regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "up regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "up regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "up regulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "up regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "up-regulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "up-regulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +synonym: "upregulation of amphisome-lysosome fusion" NARROW [GOC:TermGenie] +synonym: "upregulation of autolysosome formation" NARROW [GOC:TermGenie] +synonym: "upregulation of autophagic vacuole fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of autophagic vacuole maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of autophagosome maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of fusion of autophagosome with lysosome" NARROW [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly +is_a: GO:1901096 ! regulation of autophagosome maturation +relationship: positively_regulates GO:0097352 ! autophagosome maturation + +[Term] +id: GO:1901099 +name: negative regulation of signal transduction in absence of ligand +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction in absence of ligand." [GOC:TermGenie] +synonym: "down regulation of basal signaling" NARROW [GOC:TermGenie] +synonym: "down regulation of non-classical signal transduction" BROAD [GOC:TermGenie] +synonym: "down regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] +synonym: "down regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] +synonym: "down-regulation of basal signaling" NARROW [GOC:TermGenie] +synonym: "down-regulation of non-classical signal transduction" BROAD [GOC:TermGenie] +synonym: "down-regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] +synonym: "down-regulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] +synonym: "downregulation of basal signaling" NARROW [GOC:TermGenie] +synonym: "downregulation of non-classical signal transduction" BROAD [GOC:TermGenie] +synonym: "downregulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] +synonym: "downregulation of signal transduction in absence of ligand" EXACT [GOC:TermGenie] +synonym: "inhibition of signal transduction in absence of ligand" NARROW [GOC:TermGenie] +synonym: "negative regulation of non-classical signal transduction" BROAD [GOC:TermGenie] +synonym: "negative regulation of signal transduction in absence of agonist" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +relationship: negatively_regulates GO:0038034 ! signal transduction in absence of ligand + +[Term] +id: GO:1901101 +name: gramicidin S metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] +synonym: "gramicidin S metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:1901102 +name: gramicidin S catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] +synonym: "gramicidin S breakdown" EXACT [GOC:TermGenie] +synonym: "gramicidin S catabolism" EXACT [GOC:TermGenie] +synonym: "gramicidin S degradation" EXACT [GOC:TermGenie] +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:1901101 ! gramicidin S metabolic process + +[Term] +id: GO:1901103 +name: gramicidin S biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gramicidin S." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00102] +synonym: "gramicidin S anabolism" EXACT [GOC:TermGenie] +synonym: "gramicidin S biosynthesis" EXACT [GOC:TermGenie] +synonym: "gramicidin S formation" EXACT [GOC:TermGenie] +synonym: "gramicidin S synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:1901101 ! gramicidin S metabolic process + +[Term] +id: GO:1901104 +name: tetracenomycin C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] +synonym: "tetracenomycin C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:1901105 +name: tetracenomycin C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] +synonym: "tetracenomycin C breakdown" EXACT [GOC:TermGenie] +synonym: "tetracenomycin C catabolism" EXACT [GOC:TermGenie] +synonym: "tetracenomycin C degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1901104 ! tetracenomycin C metabolic process + +[Term] +id: GO:1901106 +name: tetracenomycin C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tetracenomycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00174] +synonym: "tetracenomycin C anabolism" EXACT [GOC:TermGenie] +synonym: "tetracenomycin C biosynthesis" EXACT [GOC:TermGenie] +synonym: "tetracenomycin C formation" EXACT [GOC:TermGenie] +synonym: "tetracenomycin C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1901104 ! tetracenomycin C metabolic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:1901107 +name: granaticin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] +synonym: "granaticin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1901108 +name: granaticin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] +synonym: "granaticin breakdown" EXACT [GOC:TermGenie] +synonym: "granaticin catabolism" EXACT [GOC:TermGenie] +synonym: "granaticin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901107 ! granaticin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1901109 +name: granaticin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of granaticin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00175] +synonym: "granaticin anabolism" EXACT [GOC:TermGenie] +synonym: "granaticin biosynthesis" EXACT [GOC:TermGenie] +synonym: "granaticin formation" EXACT [GOC:TermGenie] +synonym: "granaticin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:1901107 ! granaticin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1901110 +name: actinorhodin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] +synonym: "actinorhodin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1901111 +name: actinorhodin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] +synonym: "actinorhodin breakdown" EXACT [GOC:TermGenie] +synonym: "actinorhodin catabolism" EXACT [GOC:TermGenie] +synonym: "actinorhodin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901110 ! actinorhodin metabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1901112 +name: actinorhodin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of actinorhodin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00173] +synonym: "actinorhodin anabolism" EXACT [GOC:TermGenie] +synonym: "actinorhodin biosynthesis" EXACT [GOC:TermGenie] +synonym: "actinorhodin formation" EXACT [GOC:TermGenie] +synonym: "actinorhodin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901110 ! actinorhodin metabolic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1901113 +name: erythromycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] +synonym: "erythromycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0033067 ! macrolide metabolic process + +[Term] +id: GO:1901114 +name: erythromycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] +synonym: "erythromycin breakdown" EXACT [GOC:TermGenie] +synonym: "erythromycin catabolism" EXACT [GOC:TermGenie] +synonym: "erythromycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:1901113 ! erythromycin metabolic process +is_a: GO:1901335 ! lactone catabolic process + +[Term] +id: GO:1901115 +name: erythromycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of erythromycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00240] +synonym: "erythromycin anabolism" EXACT [GOC:TermGenie] +synonym: "erythromycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "erythromycin formation" EXACT [GOC:TermGenie] +synonym: "erythromycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0033068 ! macrolide biosynthetic process +is_a: GO:1901113 ! erythromycin metabolic process + +[Term] +id: GO:1901116 +name: cephamycin C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] +synonym: "cephamycin C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:1901117 +name: cephamycin C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] +synonym: "cephamycin C breakdown" EXACT [GOC:TermGenie] +synonym: "cephamycin C catabolism" EXACT [GOC:TermGenie] +synonym: "cephamycin C degradation" EXACT [GOC:TermGenie] +is_a: GO:0030655 ! beta-lactam antibiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901116 ! cephamycin C metabolic process + +[Term] +id: GO:1901118 +name: cephamycin C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cephamycin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00183] +synonym: "cephamycin C anabolism" EXACT [GOC:TermGenie] +synonym: "cephamycin C biosynthesis" EXACT [GOC:TermGenie] +synonym: "cephamycin C formation" EXACT [GOC:TermGenie] +synonym: "cephamycin C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901116 ! cephamycin C metabolic process + +[Term] +id: GO:1901119 +name: tobramycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] +synonym: "tobramycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:1901120 +name: tobramycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] +synonym: "tobramycin breakdown" EXACT [GOC:TermGenie] +synonym: "tobramycin catabolism" EXACT [GOC:TermGenie] +synonym: "tobramycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901119 ! tobramycin metabolic process + +[Term] +id: GO:1901121 +name: tobramycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tobramycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00971] +synonym: "tobramycin anabolism" EXACT [GOC:TermGenie] +synonym: "tobramycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "tobramycin formation" EXACT [GOC:TermGenie] +synonym: "tobramycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901119 ! tobramycin metabolic process + +[Term] +id: GO:1901122 +name: bacitracin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] +synonym: "bacitracin A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006518 ! peptide metabolic process + +[Term] +id: GO:1901123 +name: bacitracin A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] +synonym: "bacitracin A breakdown" EXACT [GOC:TermGenie] +synonym: "bacitracin A catabolism" EXACT [GOC:TermGenie] +synonym: "bacitracin A degradation" EXACT [GOC:TermGenie] +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:1901122 ! bacitracin A metabolic process + +[Term] +id: GO:1901124 +name: bacitracin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bacitracin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00179] +synonym: "bacitracin A anabolism" EXACT [GOC:TermGenie] +synonym: "bacitracin A biosynthesis" EXACT [GOC:TermGenie] +synonym: "bacitracin A formation" EXACT [GOC:TermGenie] +synonym: "bacitracin A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:1901122 ! bacitracin A metabolic process + +[Term] +id: GO:1901125 +name: candicidin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] +synonym: "candicidin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901126 +name: candicidin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] +synonym: "candicidin breakdown" EXACT [GOC:TermGenie] +synonym: "candicidin catabolism" EXACT [GOC:TermGenie] +synonym: "candicidin degradation" EXACT [GOC:TermGenie] +is_a: GO:1901125 ! candicidin metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901127 +name: candicidin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of candicidin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00101] +synonym: "candicidin anabolism" EXACT [GOC:TermGenie] +synonym: "candicidin biosynthesis" EXACT [GOC:TermGenie] +synonym: "candicidin formation" EXACT [GOC:TermGenie] +synonym: "candicidin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901125 ! candicidin metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901128 +name: gentamycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] +synonym: "gentamycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:1901129 +name: gentamycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] +synonym: "gentamycin breakdown" EXACT [GOC:TermGenie] +synonym: "gentamycin catabolism" EXACT [GOC:TermGenie] +synonym: "gentamycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901128 ! gentamycin metabolic process + +[Term] +id: GO:1901130 +name: gentamycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of gentamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00967] +synonym: "gentamycin anabolism" EXACT [GOC:TermGenie] +synonym: "gentamycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "gentamycin formation" EXACT [GOC:TermGenie] +synonym: "gentamycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901128 ! gentamycin metabolic process + +[Term] +id: GO:1901131 +name: kanamycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] +synonym: "kanamycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:1901132 +name: kanamycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] +synonym: "kanamycin breakdown" EXACT [GOC:TermGenie] +synonym: "kanamycin catabolism" EXACT [GOC:TermGenie] +synonym: "kanamycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901131 ! kanamycin metabolic process + +[Term] +id: GO:1901133 +name: kanamycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of kanamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00965] +synonym: "kanamycin anabolism" EXACT [GOC:TermGenie] +synonym: "kanamycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "kanamycin formation" EXACT [GOC:TermGenie] +synonym: "kanamycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901131 ! kanamycin metabolic process + +[Term] +id: GO:1901135 +name: carbohydrate derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] +subset: goslim_agr +subset: goslim_generic +subset: goslim_mouse +synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901136 +name: carbohydrate derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] +synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] +is_a: GO:1901135 ! carbohydrate derivative metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901137 +name: carbohydrate derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] +synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] +synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901135 ! carbohydrate derivative metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901140 +name: p-coumaryl alcohol transport +namespace: biological_process +def: "The directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] +synonym: "4-hydroxycinnamyl alcohol transport" EXACT [] +is_a: GO:0015850 ! organic hydroxy compound transport + +[Term] +id: GO:1901141 +name: regulation of lignin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lignin biosynthetic process." [GOC:TermGenie] +synonym: "regulation of lignin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of lignin formation" EXACT [GOC:TermGenie] +synonym: "regulation of lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process +relationship: regulates GO:0009809 ! lignin biosynthetic process + +[Term] +id: GO:1901142 +name: insulin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving insulin." [GOC:TermGenie] +synonym: "insulin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:1901143 +name: insulin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of insulin." [GOC:TermGenie] +synonym: "insulin breakdown" EXACT [GOC:TermGenie] +synonym: "insulin catabolism" EXACT [GOC:TermGenie] +synonym: "insulin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030163 ! protein catabolic process +is_a: GO:1901142 ! insulin metabolic process + +[Term] +id: GO:1901144 +name: obsolete insulin biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of insulin." [GOC:TermGenie] +synonym: "insulin anabolism" EXACT [GOC:TermGenie] +synonym: "insulin biosynthesis" EXACT [GOC:TermGenie] +synonym: "insulin biosynthetic process" EXACT [] +synonym: "insulin formation" EXACT [GOC:TermGenie] +synonym: "insulin synthesis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901145 +name: mesenchymal cell apoptotic process involved in nephron morphogenesis +namespace: biological_process +def: "Any mesenchymal cell apoptotic process that is involved in nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +is_a: GO:0097152 ! mesenchymal cell apoptotic process +relationship: part_of GO:0072028 ! nephron morphogenesis + +[Term] +id: GO:1901146 +name: mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis +namespace: biological_process +def: "Any mesenchymal cell apoptotic process that is involved in mesonephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] +is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis +relationship: part_of GO:0061228 ! mesonephric nephron morphogenesis + +[Term] +id: GO:1901147 +name: mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis +namespace: biological_process +def: "Any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis." [GOC:mtg_apoptosis, GOC:TermGenie] +is_a: GO:1900200 ! mesenchymal cell apoptotic process involved in metanephros development +is_a: GO:1901145 ! mesenchymal cell apoptotic process involved in nephron morphogenesis +relationship: part_of GO:0072273 ! metanephric nephron morphogenesis + +[Term] +id: GO:1901148 +name: gene expression involved in extracellular matrix organization +namespace: biological_process +def: "Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form." [GOC:pg, GOC:TermGenie, PMID:18668558] +synonym: "expression of extracellular matrix proteins" EXACT [GOC:bf] +synonym: "extracellular matrix protein production" RELATED [GOC:pg] +is_a: GO:0010467 ! gene expression +relationship: part_of GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:1901149 +name: salicylic acid binding +namespace: molecular_function +def: "Binding to salicylic acid." [GOC:TermGenie, PMID:22699612] +synonym: "salicylic acid receptor" NARROW [PMID:22699612] +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:1901150 +name: vistamycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] +synonym: "ribostamycin metabolic process" EXACT [GOC:yaf] +synonym: "ribostamycin metabolism" EXACT [GOC:yaf] +synonym: "vistamycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:1901151 +name: vistamycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] +synonym: "ribostamycin breakdown" EXACT [GOC:yaf] +synonym: "ribostamycin catabolic process" EXACT [GOC:yaf] +synonym: "ribostamycin catabolism" EXACT [GOC:yaf] +synonym: "ribostamycin degradation" EXACT [GOC:yaf] +synonym: "vistamycin breakdown" EXACT [GOC:TermGenie] +synonym: "vistamycin catabolism" EXACT [GOC:TermGenie] +synonym: "vistamycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901150 ! vistamycin metabolic process + +[Term] +id: GO:1901152 +name: vistamycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vistamycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00972] +synonym: "ribostamycin anabolism" EXACT [GOC:yaf] +synonym: "ribostamycin biosynthesis" EXACT [GOC:yaf] +synonym: "ribostamycin biosynthetic process" EXACT [GOC:yaf] +synonym: "ribostamycin formation" EXACT [GOC:yaf] +synonym: "ribostamycin synthesis" EXACT [GOC:yaf] +synonym: "vistamycin anabolism" EXACT [GOC:TermGenie] +synonym: "vistamycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "vistamycin formation" EXACT [GOC:TermGenie] +synonym: "vistamycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901150 ! vistamycin metabolic process + +[Term] +id: GO:1901153 +name: paromomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] +synonym: "paromomycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:1901154 +name: paromomycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] +synonym: "paromomycin breakdown" EXACT [GOC:TermGenie] +synonym: "paromomycin catabolism" EXACT [GOC:TermGenie] +synonym: "paromomycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901153 ! paromomycin metabolic process + +[Term] +id: GO:1901155 +name: paromomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of paromomycin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00970] +synonym: "paromomycin anabolism" EXACT [GOC:TermGenie] +synonym: "paromomycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "paromomycin formation" EXACT [GOC:TermGenie] +synonym: "paromomycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901153 ! paromomycin metabolic process + +[Term] +id: GO:1901156 +name: neomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] +synonym: "neomycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process + +[Term] +id: GO:1901157 +name: neomycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] +synonym: "neomycin breakdown" EXACT [GOC:TermGenie] +synonym: "neomycin catabolism" EXACT [GOC:TermGenie] +synonym: "neomycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901156 ! neomycin metabolic process + +[Term] +id: GO:1901158 +name: neomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-7016, UniPathway:UPA00969] +synonym: "neomycin anabolism" EXACT [GOC:TermGenie] +synonym: "neomycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "neomycin formation" EXACT [GOC:TermGenie] +synonym: "neomycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901156 ! neomycin metabolic process + +[Term] +id: GO:1901159 +name: xylulose 5-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate." [GOC:bf, GOC:TermGenie] +synonym: "xylulose 5-phosphate anabolism" EXACT [GOC:TermGenie] +synonym: "xylulose 5-phosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "xylulose 5-phosphate formation" EXACT [GOC:TermGenie] +synonym: "xylulose 5-phosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051167 ! xylulose 5-phosphate metabolic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:1901160 +name: primary amino compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving primary amino compound." [GOC:TermGenie] +synonym: "primary amino compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1901161 +name: primary amino compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of primary amino compound." [GOC:TermGenie] +synonym: "primary amino compound breakdown" EXACT [GOC:TermGenie] +synonym: "primary amino compound catabolism" EXACT [GOC:TermGenie] +synonym: "primary amino compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901160 ! primary amino compound metabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process + +[Term] +id: GO:1901162 +name: primary amino compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of primary amino compound." [GOC:TermGenie] +synonym: "primary amino compound anabolism" EXACT [GOC:TermGenie] +synonym: "primary amino compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "primary amino compound formation" EXACT [GOC:TermGenie] +synonym: "primary amino compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901160 ! primary amino compound metabolic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:1901163 +name: regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0061450 ! trophoblast cell migration + +[Term] +id: GO:1901164 +name: negative regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of trophoblast cell migration" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901163 ! regulation of trophoblast cell migration +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0061450 ! trophoblast cell migration + +[Term] +id: GO:1901165 +name: positive regulation of trophoblast cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of trophoblast cell migration." [GOC:BHF, GOC:TermGenie] +synonym: "activation of trophoblast cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of trophoblast cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of trophoblast cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901163 ! regulation of trophoblast cell migration +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0061450 ! trophoblast cell migration + +[Term] +id: GO:1901166 +name: neural crest cell migration involved in autonomic nervous system development +namespace: biological_process +def: "Any neural crest cell migration that is involved in autonomic nervous system development." [GOC:BHF, GOC:TermGenie] +is_a: GO:0001755 ! neural crest cell migration +relationship: part_of GO:0048483 ! autonomic nervous system development + +[Term] +id: GO:1901167 +name: 3-chlorocatechol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] +synonym: "3-chlorocatechol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1901168 +name: 3-chlorocatechol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] +synonym: "3-chlorocatechol breakdown" EXACT [GOC:TermGenie] +synonym: "3-chlorocatechol catabolism" EXACT [GOC:TermGenie] +synonym: "3-chlorocatechol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:1901167 ! 3-chlorocatechol metabolic process + +[Term] +id: GO:1901169 +name: 3-chlorocatechol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-chlorocatechol." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00083] +synonym: "3-chlorocatechol anabolism" EXACT [GOC:TermGenie] +synonym: "3-chlorocatechol biosynthesis" EXACT [GOC:TermGenie] +synonym: "3-chlorocatechol formation" EXACT [GOC:TermGenie] +synonym: "3-chlorocatechol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:1901167 ! 3-chlorocatechol metabolic process + +[Term] +id: GO:1901170 +name: naphthalene catabolic process +namespace: biological_process +alt_id: GO:0018931 +def: "The chemical reactions and pathways resulting in the breakdown of naphthalene." [GOC:TermGenie, GOC:yaf, PMID:11133965] +synonym: "naphthalene breakdown" EXACT [GOC:TermGenie] +synonym: "naphthalene catabolism" EXACT [GOC:TermGenie] +synonym: "naphthalene degradation" EXACT [GOC:TermGenie] +synonym: "naphthalene metabolic process" RELATED [] +synonym: "naphthalene metabolism" RELATED [] +xref: UM-BBD_pathwayID:naph +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0120253 ! hydrocarbon catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1901171 +name: obsolete naphthalene biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of naphthalene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00082] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "naphthalene anabolism" EXACT [GOC:TermGenie] +synonym: "naphthalene biosynthesis" EXACT [GOC:TermGenie] +synonym: "naphthalene formation" EXACT [GOC:TermGenie] +synonym: "naphthalene synthesis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901172 +name: phytoene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] +synonym: "phytoene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901173 +name: phytoene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] +synonym: "phytoene breakdown" EXACT [GOC:TermGenie] +synonym: "phytoene catabolism" EXACT [GOC:TermGenie] +synonym: "phytoene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901172 ! phytoene metabolic process + +[Term] +id: GO:1901174 +name: phytoene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phytoene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00799] +synonym: "phytoene anabolism" EXACT [GOC:TermGenie] +synonym: "phytoene biosynthesis" EXACT [GOC:TermGenie] +synonym: "phytoene formation" EXACT [GOC:TermGenie] +synonym: "phytoene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901172 ! phytoene metabolic process + +[Term] +id: GO:1901175 +name: lycopene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] +synonym: "lycopene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901176 +name: lycopene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] +synonym: "lycopene breakdown" EXACT [GOC:TermGenie] +synonym: "lycopene catabolism" EXACT [GOC:TermGenie] +synonym: "lycopene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901175 ! lycopene metabolic process + +[Term] +id: GO:1901177 +name: lycopene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lycopene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00803] +synonym: "lycopene anabolism" EXACT [GOC:TermGenie] +synonym: "lycopene biosynthesis" EXACT [GOC:TermGenie] +synonym: "lycopene formation" EXACT [GOC:TermGenie] +synonym: "lycopene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901175 ! lycopene metabolic process + +[Term] +id: GO:1901178 +name: spheroidene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] +synonym: "spheroidene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016122 ! xanthophyll metabolic process +is_a: GO:0018904 ! ether metabolic process + +[Term] +id: GO:1901179 +name: spheroidene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] +synonym: "spheroidene breakdown" EXACT [GOC:TermGenie] +synonym: "spheroidene catabolism" EXACT [GOC:TermGenie] +synonym: "spheroidene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:1901178 ! spheroidene metabolic process +is_a: GO:1901502 ! ether catabolic process + +[Term] +id: GO:1901180 +name: spheroidene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of spheroidene." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00683] +synonym: "spheroidene anabolism" EXACT [GOC:TermGenie] +synonym: "spheroidene biosynthesis" EXACT [GOC:TermGenie] +synonym: "spheroidene formation" EXACT [GOC:TermGenie] +synonym: "spheroidene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:1901178 ! spheroidene metabolic process +is_a: GO:1901503 ! ether biosynthetic process + +[Term] +id: GO:1901181 +name: negative regulation of cellular response to caffeine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to caffeine." [GOC:TermGenie] +synonym: "down regulation of cellular response to caffeine" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to caffeine" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to caffeine" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to caffeine" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +relationship: negatively_regulates GO:0071313 ! cellular response to caffeine + +[Term] +id: GO:1901182 +name: regulation of camalexin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie] +synonym: "regulation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "regulation of camalexin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0052319 ! regulation of phytoalexin biosynthetic process +relationship: regulates GO:0010120 ! camalexin biosynthetic process + +[Term] +id: GO:1901183 +name: positive regulation of camalexin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of camalexin biosynthetic process." [GOC:TermGenie] +synonym: "activation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of camalexin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "activation of camalexin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of camalexin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of camalexin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of camalexin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of camalexin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of camalexin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of camalexin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of camalexin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of camalexin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process +is_a: GO:1901182 ! regulation of camalexin biosynthetic process +relationship: positively_regulates GO:0010120 ! camalexin biosynthetic process + +[Term] +id: GO:1901184 +name: regulation of ERBB signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:1901185 +name: negative regulation of ERBB signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "inhibition of ERBB signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1901184 ! regulation of ERBB signaling pathway +relationship: negatively_regulates GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:1901186 +name: positive regulation of ERBB signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ERBB signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "activation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "activation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "activation of ERBB signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of EGF receptor family signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of EGFR family signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of ErbB signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of ERBB signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of ERBB signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1901184 ! regulation of ERBB signaling pathway +relationship: positively_regulates GO:0038127 ! ERBB signaling pathway + +[Term] +id: GO:1901187 +name: regulation of ephrin receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048013 ! ephrin receptor signaling pathway + +[Term] +id: GO:1901188 +name: negative regulation of ephrin receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of ephrin receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway +relationship: negatively_regulates GO:0048013 ! ephrin receptor signaling pathway + +[Term] +id: GO:1901189 +name: positive regulation of ephrin receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ephrin receptor signaling pathway." [GOC:BHF, GOC:TermGenie] +synonym: "activation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "activation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "activation of ephrin receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Eph receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Eph receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of ephrin receptor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1901187 ! regulation of ephrin receptor signaling pathway +relationship: positively_regulates GO:0048013 ! ephrin receptor signaling pathway + +[Term] +id: GO:1901190 +name: regulation of formation of translation initiation ternary complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] +synonym: "regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0001677 ! formation of translation initiation ternary complex + +[Term] +id: GO:1901191 +name: negative regulation of formation of translation initiation ternary complex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] +synonym: "down regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "down regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "down-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "downregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] +synonym: "inhibition of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0045947 ! negative regulation of translational initiation +is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex +relationship: negatively_regulates GO:0001677 ! formation of translation initiation ternary complex + +[Term] +id: GO:1901192 +name: positive regulation of formation of translation initiation ternary complex +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex." [GOC:TermGenie] +synonym: "activation of formation of translation initiation ternary complex" NARROW [GOC:TermGenie] +synonym: "activation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "up regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "up-regulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of formation of translation initiation ternary complex" EXACT [GOC:TermGenie] +synonym: "upregulation of translation initiation ternary complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1901190 ! regulation of formation of translation initiation ternary complex +relationship: positively_regulates GO:0001677 ! formation of translation initiation ternary complex + +[Term] +id: GO:1901193 +name: regulation of formation of translation preinitiation complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] +synonym: "regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +relationship: regulates GO:0001731 ! formation of translation preinitiation complex + +[Term] +id: GO:1901194 +name: negative regulation of formation of translation preinitiation complex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] +synonym: "down regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "down regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "down regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "down-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "down-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "downregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "downregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "inhibition of formation of translation preinitiation complex" NARROW [GOC:TermGenie] +synonym: "inhibition of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "negative regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1901193 ! regulation of formation of translation preinitiation complex +is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation +relationship: negatively_regulates GO:0001731 ! formation of translation preinitiation complex + +[Term] +id: GO:1901195 +name: positive regulation of formation of translation preinitiation complex +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex." [GOC:TermGenie] +synonym: "activation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "activation of formation of translation preinitiation complex" NARROW [GOC:TermGenie] +synonym: "activation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "positive regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "up regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "up regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "up-regulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "up-regulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of formation of translation pre-initiation complex" EXACT [GOC:TermGenie] +synonym: "upregulation of formation of translation preinitiation complex" EXACT [GOC:TermGenie] +synonym: "upregulation of translation preinitiation complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1901193 ! regulation of formation of translation preinitiation complex +relationship: positively_regulates GO:0001731 ! formation of translation preinitiation complex + +[Term] +id: GO:1901196 +name: positive regulation of calcium-mediated signaling involved in cellular response to salt stress +namespace: biological_process +def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to salt stress." [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to salt stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular salinity response" EXACT [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" NARROW [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to salt stress" NARROW [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular salinity response" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to salt stress" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular salinity response" EXACT [GOC:TermGenie] +is_a: GO:0050850 ! positive regulation of calcium-mediated signaling +relationship: part_of GO:0071472 ! cellular response to salt stress + +[Term] +id: GO:1901197 +name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion +namespace: biological_process +def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +is_a: GO:0050850 ! positive regulation of calcium-mediated signaling +relationship: part_of GO:0071277 ! cellular response to calcium ion + +[Term] +id: GO:1901198 +name: positive regulation of calcium ion transport into cytosol involved in cellular response to calcium ion +namespace: biological_process +def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to calcium ion." [GOC:TermGenie] +synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol +relationship: part_of GO:0071277 ! cellular response to calcium ion + +[Term] +id: GO:1901199 +name: positive regulation of calcium ion transport into cytosol involved in cellular response to salt stress +namespace: biological_process +def: "Any positive regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie] +synonym: "positive regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie] +is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol +relationship: part_of GO:0071472 ! cellular response to salt stress + +[Term] +id: GO:1901200 +name: negative regulation of calcium ion transport into cytosol involved in cellular response to salt stress +namespace: biological_process +def: "Any negative regulation of calcium ion transport into cytosol that is involved in cellular response to salt stress." [GOC:TermGenie] +synonym: "negative regulation of calcium ion transport into cytosol involved in cellular response to ionic osmotic stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of calcium ion transport into cytosol involved in cellular salinity response" EXACT [GOC:TermGenie] +is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol +relationship: part_of GO:0071472 ! cellular response to salt stress + +[Term] +id: GO:1901201 +name: regulation of extracellular matrix assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: regulates GO:0085029 ! extracellular matrix assembly + +[Term] +id: GO:1901202 +name: negative regulation of extracellular matrix assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of extracellular matrix assembly" NARROW [GOC:TermGenie] +is_a: GO:1901201 ! regulation of extracellular matrix assembly +is_a: GO:1903054 ! negative regulation of extracellular matrix organization +relationship: negatively_regulates GO:0085029 ! extracellular matrix assembly + +[Term] +id: GO:1901203 +name: positive regulation of extracellular matrix assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly." [GOC:BHF, GOC:TermGenie] +synonym: "activation of extracellular matrix assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular matrix assembly" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:1901201 ! regulation of extracellular matrix assembly +is_a: GO:1903055 ! positive regulation of extracellular matrix organization +relationship: positively_regulates GO:0085029 ! extracellular matrix assembly + +[Term] +id: GO:1901204 +name: obsolete regulation of adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901205 +name: obsolete negative regulation of adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "down regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "down-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "downregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "inhibition of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "negative regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901206 +name: obsolete positive regulation of adrenergic receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of a cardiac adrenergic receptor signaling pathway." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "activation of adrenergic receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "activation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "positive regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "up regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "up-regulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "upregulation of adrenergic receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of adrenergic receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-adrenergic receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901207 +name: regulation of heart looping +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of cardiac looping" EXACT [GOC:TermGenie] +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0001947 ! heart looping + +[Term] +id: GO:1901208 +name: negative regulation of heart looping +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "down regulation of heart looping" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart looping" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "downregulation of heart looping" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac looping" EXACT [GOC:TermGenie] +synonym: "inhibition of heart looping" NARROW [GOC:TermGenie] +synonym: "negative regulation of cardiac looping" EXACT [GOC:TermGenie] +is_a: GO:1901207 ! regulation of heart looping +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0001947 ! heart looping + +[Term] +id: GO:1901209 +name: positive regulation of heart looping +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heart looping." [GOC:BHF, GOC:TermGenie] +synonym: "activation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "activation of heart looping" NARROW [GOC:TermGenie] +synonym: "positive regulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "up regulation of heart looping" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart looping" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac looping" EXACT [GOC:TermGenie] +synonym: "upregulation of heart looping" EXACT [GOC:TermGenie] +is_a: GO:1901207 ! regulation of heart looping +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0001947 ! heart looping + +[Term] +id: GO:1901210 +name: regulation of cardiac chamber formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of heart chamber formation" EXACT [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0003207 ! cardiac chamber formation + +[Term] +id: GO:1901211 +name: negative regulation of cardiac chamber formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "down regulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "downregulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac chamber formation" NARROW [GOC:TermGenie] +synonym: "inhibition of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of heart chamber formation" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901210 ! regulation of cardiac chamber formation +relationship: negatively_regulates GO:0003207 ! cardiac chamber formation + +[Term] +id: GO:1901212 +name: positive regulation of cardiac chamber formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber formation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of cardiac chamber formation" NARROW [GOC:TermGenie] +synonym: "activation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "up regulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart chamber formation" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac chamber formation" EXACT [GOC:TermGenie] +synonym: "upregulation of heart chamber formation" EXACT [GOC:TermGenie] +is_a: GO:1901210 ! regulation of cardiac chamber formation +is_a: GO:1901221 ! positive regulation of cardiac chamber morphogenesis +relationship: positively_regulates GO:0003207 ! cardiac chamber formation + +[Term] +id: GO:1901213 +name: regulation of transcription from RNA polymerase II promoter involved in heart development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time." [GOC:BHF, GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: part_of GO:0007507 ! heart development + +[Term] +id: GO:1901214 +name: regulation of neuron death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] +synonym: "regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "regulation of neuronal cell death" EXACT [GOC:TermGenie] +is_a: GO:0010941 ! regulation of cell death +relationship: regulates GO:0070997 ! neuron death + +[Term] +id: GO:1901215 +name: negative regulation of neuron death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] +synonym: "down regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron death" EXACT [GOC:TermGenie] +synonym: "down regulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron death" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron death" EXACT [GOC:TermGenie] +synonym: "downregulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "inhibition of neuron cell death" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron death" NARROW [GOC:TermGenie] +synonym: "inhibition of neuronal cell death" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuronal cell death" EXACT [GOC:TermGenie] +is_a: GO:0060548 ! negative regulation of cell death +is_a: GO:1901214 ! regulation of neuron death +relationship: negatively_regulates GO:0070997 ! neuron death + +[Term] +id: GO:1901216 +name: positive regulation of neuron death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] +synonym: "activation of neuron cell death" NARROW [GOC:TermGenie] +synonym: "activation of neuron death" NARROW [GOC:TermGenie] +synonym: "activation of neuronal cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "up regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "up regulation of neuron death" EXACT [GOC:TermGenie] +synonym: "up regulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuron death" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuronal cell death" EXACT [GOC:TermGenie] +synonym: "upregulation of neuron cell death" EXACT [GOC:TermGenie] +synonym: "upregulation of neuron death" EXACT [GOC:TermGenie] +synonym: "upregulation of neuronal cell death" EXACT [GOC:TermGenie] +is_a: GO:0010942 ! positive regulation of cell death +is_a: GO:1901214 ! regulation of neuron death +relationship: positively_regulates GO:0070997 ! neuron death + +[Term] +id: GO:1901217 +name: regulation of holin activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie] +is_a: GO:0022898 ! regulation of transmembrane transporter activity +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0019076 ! viral release from host cell + +[Term] +id: GO:1901218 +name: negative regulation of holin activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of holin activity." [GOC:bm, GOC:TermGenie] +synonym: "antiholin activity" EXACT [] +synonym: "down regulation of holin activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of holin activity" EXACT [GOC:TermGenie] +synonym: "downregulation of holin activity" EXACT [GOC:TermGenie] +synonym: "inhibition of holin activity" NARROW [GOC:TermGenie] +synonym: "phage antiholin" NARROW [GOC:bm] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0048525 ! negative regulation of viral process +is_a: GO:0051711 ! negative regulation of killing of cells of another organism +is_a: GO:1901217 ! regulation of holin activity +relationship: negatively_regulates GO:0019076 ! viral release from host cell + +[Term] +id: GO:1901219 +name: regulation of cardiac chamber morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:2000826 ! regulation of heart morphogenesis +relationship: regulates GO:0003206 ! cardiac chamber morphogenesis + +[Term] +id: GO:1901220 +name: negative regulation of cardiac chamber morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of heart chamber morphogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis +relationship: negatively_regulates GO:0003206 ! cardiac chamber morphogenesis + +[Term] +id: GO:1901221 +name: positive regulation of cardiac chamber morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis." [GOC:BHF, GOC:TermGenie] +synonym: "activation of cardiac chamber morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of heart chamber morphogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac chamber morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of heart chamber morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1901219 ! regulation of cardiac chamber morphogenesis +relationship: positively_regulates GO:0003206 ! cardiac chamber morphogenesis + +[Term] +id: GO:1901222 +name: regulation of NIK/NF-kappaB signaling +namespace: biological_process +alt_id: GO:0042345 +alt_id: GO:0042348 +def: "Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] +synonym: "NF-kappaB import into nucleus" NARROW [] +synonym: "NF-KB import into nucleus" NARROW [GOC:bf] +synonym: "regulation of NF-kappaB import into nucleus" NARROW [] +synonym: "regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0038061 ! NIK/NF-kappaB signaling + +[Term] +id: GO:1901223 +name: negative regulation of NIK/NF-kappaB signaling +namespace: biological_process +alt_id: GO:0042347 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] +synonym: "down regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "down regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "down regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "down regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "down-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "down-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "down-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "downregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "downregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "downregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "inhibition of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "inhibition of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "negative regulation of NF-kappaB import into nucleus" NARROW [] +synonym: "negative regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "negative regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "negative regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "negative regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0038061 ! NIK/NF-kappaB signaling + +[Term] +id: GO:1901224 +name: positive regulation of NIK/NF-kappaB signaling +namespace: biological_process +alt_id: GO:0008588 +alt_id: GO:0042346 +def: "Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling." [GOC:TermGenie] +synonym: "activation of NIK/NF-kappaB cascade" NARROW [GOC:TermGenie] +synonym: "activation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "activation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "activation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytoplasmic NF-kappaB storage" NARROW [] +synonym: "positive regulation of NF-kappaB import into nucleus" NARROW [] +synonym: "positive regulation of NIK/NF-kappaB cascade" RELATED [GOC:signaling] +synonym: "positive regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "positive regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "positive regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "release of cytoplasmic sequestered NF-kappaB" NARROW [] +synonym: "release of NF-kappaB sequestered in cytoplasm" NARROW [] +synonym: "up regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "up regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "up regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "up-regulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "up-regulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "up-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "up-regulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +synonym: "upregulation of NIK/NF-kappaB cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of non-canonical NF-KB signaling" BROAD [GOC:TermGenie] +synonym: "upregulation of noncanonical NF-kappaB signaling" BROAD [GOC:TermGenie] +synonym: "upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway" BROAD [GOC:TermGenie] +synonym: "upregulation of p52-dependent NF-kappaB signaling" NARROW [GOC:TermGenie] +is_a: GO:1901222 ! regulation of NIK/NF-kappaB signaling +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0038061 ! NIK/NF-kappaB signaling + +[Term] +id: GO:1901225 +name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in heart development +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "downregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "inhibition of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0007507 + +[Term] +id: GO:1901226 +name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in heart development +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter involved in heart development." [GOC:BHF, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "activation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "activation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "activation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [] +synonym: "up regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up-regulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription regulation from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription regulation from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription regulation from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "upregulation of regulation of transcription from RNA polymerase II promoter, global involved in heart development" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0007507 +consider: GO:0045944 + +[Term] +id: GO:1901227 +name: negative regulation of transcription from RNA polymerase II promoter involved in heart development +namespace: biological_process +def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development + +[Term] +id: GO:1901228 +name: positive regulation of transcription from RNA polymerase II promoter involved in heart development +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in heart development." [GOC:BHF, GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in heart development" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in dorsal vessel development" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in heart development" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in heart development" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development + +[Term] +id: GO:1901229 +name: regulation of non-canonical Wnt signaling pathway via JNK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] +synonym: "regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade + +[Term] +id: GO:1901230 +name: negative regulation of non-canonical Wnt signaling pathway via JNK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "inhibition of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie] +synonym: "negative regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] +synonym: "negative regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" RELATED [GOC:signaling] +is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +relationship: negatively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade + +[Term] +id: GO:1901231 +name: positive regulation of non-canonical Wnt signaling pathway via JNK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt signaling pathway via JNK cascade." [GOC:BHF, GOC:TermGenie] +synonym: "activation of non-canonical Wnt receptor signaling pathway via JNK cascade" NARROW [GOC:TermGenie] +synonym: "activation of non-canonical Wnt receptor signalling pathway via JNK cascade" NARROW [GOC:TermGenie] +synonym: "positive regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [] +synonym: "positive regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "positive regulation of non-canonical Wnt-activated signaling pathway via JNK cascade" EXACT [GOC:signaling] +synonym: "up regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of non-canonical Wnt receptor signaling pathway via JNK cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of non-canonical Wnt receptor signalling pathway via JNK cascade" EXACT [GOC:TermGenie] +is_a: GO:1901229 ! regulation of non-canonical Wnt signaling pathway via JNK cascade +is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway +relationship: positively_regulates GO:0038031 ! non-canonical Wnt signaling pathway via JNK cascade + +[Term] +id: GO:1901232 +name: regulation of convergent extension involved in axis elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0060028 ! convergent extension involved in axis elongation + +[Term] +id: GO:1901233 +name: negative regulation of convergent extension involved in axis elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0060028 ! convergent extension involved in axis elongation + +[Term] +id: GO:1901234 +name: positive regulation of convergent extension involved in axis elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of convergent extension involved in axis elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in axis elongation" EXACT [GOC:TermGenie] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0060028 ! convergent extension involved in axis elongation + +[Term] +id: GO:1901235 +name: (R)-carnitine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of (R)-carnitine from one side of a membrane to the other." [GOC:TermGenie, PMID:16365042, PMID:20357772, PMID:20829798] +xref: RHEA:34959 +is_a: GO:0015226 ! carnitine transmembrane transporter activity + +[Term] +id: GO:1901236 +name: 4-(trimethylammonio)butanoate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 4-(trimethylammonio)butanoate from one side of a membrane to the other." [GOC:TermGenie, PMID:16952940, PMID:21784948] +xref: RHEA:32835 +is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity + +[Term] +id: GO:1901238 +name: ABC-type tungstate transporter activity +namespace: molecular_function +alt_id: GO:1901237 +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out)." [GOC:TermGenie, PMID:16952940, PMID:21784948, RHEA:35027] +synonym: "ATPase-coupled tungstate transmembrane transporter activity" RELATED [] +synonym: "tungstate transmembrane transporter activity" BROAD [] +synonym: "tungstate transmembrane-transporting ATPase activity" RELATED [] +xref: EC:7.3.2.6 +xref: RHEA:35027 +is_a: GO:0043225 ! ATPase-coupled inorganic anion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:1901239 +name: malonate(1-) transmembrane transporter activity +namespace: molecular_function +alt_id: GO:1901549 +def: "Enables the transfer of malonate(1-) from one side of a membrane to the other." [GOC:TermGenie, PMID:9128730, PMID:9573154] +synonym: "malonic acid uptake transmembrane transporter activity" RELATED [] +xref: RHEA:33115 +is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity + +[Term] +id: GO:1901241 +name: 4-hydroxyphenylacetate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other." [GOC:TermGenie, PMID:9315705] +xref: RHEA:33175 +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity + +[Term] +id: GO:1901242 +name: ABC-type doxorubicin transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + doxorubicin(in) = ADP + phosphate + doxorubicin(out)." [GOC:TermGenie, PMID:12057006, PMID:15090538] +synonym: "ATPase-coupled doxorubicin transmembrane transporter activity" RELATED [] +synonym: "doxorubicin transmembrane-transporting ATPase activity" RELATED [] +xref: TC:3.A.1.105.1 +is_a: GO:0015101 ! organic cation transmembrane transporter activity +is_a: GO:0015665 ! alcohol transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:1901244 +name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter to protect the cell or organism in response to the presence of a fungus." [GOC:kmv, GOC:TermGenie] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungi" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to fungus" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungi" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to fungus" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungi" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to fungus" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungi" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to fungus" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0045944 +consider: GO:0050832 + +[Term] +id: GO:1901245 +name: positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization +namespace: biological_process +def: "The movement of a B cell receptor (BCR) from the plasma membrane to the inside of the cell, which results in positive regulation of toll-like receptor 9 (TLR9) signaling. For example, internalized BCR signals to recruit TLR9 from multiple small endosomes to large autophagosome-like compartments to enhance TLR9 signaling." [GOC:amm, GOC:bf, GOC:TermGenie, PMID:18513998] +synonym: "BCR-induced TLR9 recruitment" NARROW [PMID:18513998] +synonym: "positive regulation of TLR9 signaling pathway by B cell receptor internalization" EXACT [GOC:TermGenie] +synonym: "positive regulation of TLR9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of TLR9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] +synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR endocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of toll-like receptor 9 signaling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] +synonym: "positive regulation of toll-like receptor 9 signalling pathway by B cell receptor internalization" EXACT [GOC:TermGenie] +synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR endocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of toll-like receptor 9 signalling pathway by BCR receptor internalization" EXACT [GOC:TermGenie] +is_a: GO:0034165 ! positive regulation of toll-like receptor 9 signaling pathway +is_a: GO:0036300 ! B cell receptor internalization +is_a: GO:0038010 ! positive regulation of signal transduction by receptor internalization + +[Term] +id: GO:1901246 +name: regulation of lung ciliated cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0061141 ! lung ciliated cell differentiation + +[Term] +id: GO:1901247 +name: negative regulation of lung ciliated cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of lung ciliated cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901246 ! regulation of lung ciliated cell differentiation +relationship: negatively_regulates GO:0061141 ! lung ciliated cell differentiation + +[Term] +id: GO:1901248 +name: positive regulation of lung ciliated cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of lung ciliated cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of lung ciliated cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901246 ! regulation of lung ciliated cell differentiation +relationship: positively_regulates GO:0061141 ! lung ciliated cell differentiation + +[Term] +id: GO:1901249 +name: regulation of lung goblet cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0060480 ! lung goblet cell differentiation + +[Term] +id: GO:1901250 +name: negative regulation of lung goblet cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of lung goblet cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901249 ! regulation of lung goblet cell differentiation +relationship: negatively_regulates GO:0060480 ! lung goblet cell differentiation + +[Term] +id: GO:1901251 +name: positive regulation of lung goblet cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of lung goblet cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of pulmonary goblet cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of lung goblet cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of pulmonary goblet cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901249 ! regulation of lung goblet cell differentiation +relationship: positively_regulates GO:0060480 ! lung goblet cell differentiation + +[Term] +id: GO:1901252 +name: regulation of intracellular transport of viral material +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of egress of virus within host cell." [GOC:bf, GOC:jl, GOC:TermGenie] +synonym: "regulation of egress of virus within host cell" RELATED [] +synonym: "regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "regulation of viral egress" EXACT [GOC:TermGenie] +is_a: GO:1903900 ! regulation of viral life cycle +relationship: regulates GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:1901253 +name: negative regulation of intracellular transport of viral material +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie] +synonym: "down regulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "down regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "down regulation of viral egress" EXACT [GOC:TermGenie] +synonym: "down-regulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral egress" EXACT [GOC:TermGenie] +synonym: "downregulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "downregulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "downregulation of viral egress" EXACT [GOC:TermGenie] +synonym: "inhibition of egress of virus within host cell" NARROW [GOC:TermGenie] +synonym: "inhibition of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "inhibition of viral egress" EXACT [GOC:TermGenie] +synonym: "negative regulation of egress of virus within host cell" RELATED [] +synonym: "negative regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral egress" EXACT [GOC:TermGenie] +is_a: GO:1901252 ! regulation of intracellular transport of viral material +is_a: GO:1903901 ! negative regulation of viral life cycle +relationship: negatively_regulates GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:1901254 +name: positive regulation of intracellular transport of viral material +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material." [GOC:bf, GOC:jl, GOC:TermGenie] +synonym: "activation of egress of virus within host cell" NARROW [GOC:TermGenie] +synonym: "activation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "activation of viral egress" EXACT [GOC:TermGenie] +synonym: "positive regulation of egress of virus within host cell" RELATED [] +synonym: "positive regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral egress" EXACT [GOC:TermGenie] +synonym: "up regulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "up regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "up regulation of viral egress" EXACT [GOC:TermGenie] +synonym: "up-regulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral egress" EXACT [GOC:TermGenie] +synonym: "upregulation of egress of virus within host cell" EXACT [GOC:TermGenie] +synonym: "upregulation of movement of virus within host cell" EXACT [GOC:TermGenie] +synonym: "upregulation of viral egress" EXACT [GOC:TermGenie] +is_a: GO:1901252 ! regulation of intracellular transport of viral material +is_a: GO:1903902 ! positive regulation of viral life cycle +relationship: positively_regulates GO:0075733 ! intracellular transport of virus + +[Term] +id: GO:1901255 +name: nucleotide-excision repair involved in interstrand cross-link repair +namespace: biological_process +def: "Any nucleotide-excision repair that is involved in interstrand cross-link repair." [GOC:TermGenie, PMID:22064477] +synonym: "NER involved in ICL repair" EXACT [GOC:TermGenie] +synonym: "NER involved in interstrand cross-link repair" EXACT [GOC:TermGenie] +synonym: "nucleotide-excision repair involved in ICL repair" EXACT [GOC:TermGenie] +is_a: GO:0006289 ! nucleotide-excision repair +relationship: part_of GO:0036297 ! interstrand cross-link repair + +[Term] +id: GO:1901256 +name: regulation of macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of M-CSF production" EXACT [GOC:TermGenie] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0036301 ! macrophage colony-stimulating factor production + +[Term] +id: GO:1901257 +name: negative regulation of macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "down regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +synonym: "down-regulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "down-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +synonym: "downregulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "downregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +synonym: "inhibition of M-CSF production" EXACT [GOC:TermGenie] +synonym: "inhibition of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie] +synonym: "negative regulation of M-CSF production" EXACT [GOC:TermGenie] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production +relationship: negatively_regulates GO:0036301 ! macrophage colony-stimulating factor production + +[Term] +id: GO:1901258 +name: positive regulation of macrophage colony-stimulating factor production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor production." [GOC:BHF, GOC:TermGenie] +synonym: "activation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "activation of macrophage colony-stimulating factor production" NARROW [GOC:TermGenie] +synonym: "positive regulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "up regulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "up regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +synonym: "up-regulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "up-regulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +synonym: "upregulation of M-CSF production" EXACT [GOC:TermGenie] +synonym: "upregulation of macrophage colony-stimulating factor production" EXACT [GOC:TermGenie] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1901256 ! regulation of macrophage colony-stimulating factor production +relationship: positively_regulates GO:0036301 ! macrophage colony-stimulating factor production + +[Term] +id: GO:1901259 +name: chloroplast rRNA processing +namespace: biological_process +def: "Any rRNA processing that takes place in chloroplast." [GOC:TermGenie] +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:1901260 +name: peptidyl-lysine hydroxylation involved in bacterial-type EF-P lysine modification +namespace: biological_process +def: "Any peptidyl-lysine hydroxylation that is involved in bacterial-type EF-P lysine modification." [GOC:imk, GOC:TermGenie, PMID:22706199] +synonym: "EF-P lysine hydroxylation" RELATED [PMID:3555234] +is_a: GO:0017185 ! peptidyl-lysine hydroxylation +relationship: part_of GO:0072580 ! bacterial-type EF-P lysine modification + +[Term] +id: GO:1901261 +name: regulation of sorocarp spore cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] +is_a: GO:0031156 ! regulation of sorocarp development +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0044671 ! sorocarp spore cell differentiation + +[Term] +id: GO:1901262 +name: negative regulation of sorocarp spore cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] +synonym: "down regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of sorocarp spore cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation +relationship: negatively_regulates GO:0044671 ! sorocarp spore cell differentiation + +[Term] +id: GO:1901263 +name: positive regulation of sorocarp spore cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sorocarp spore cell differentiation." [GOC:rjd, GOC:TermGenie] +synonym: "activation of sorocarp spore cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of sorocarp spore cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1901261 ! regulation of sorocarp spore cell differentiation +relationship: positively_regulates GO:0044671 ! sorocarp spore cell differentiation + +[Term] +id: GO:1901264 +name: carbohydrate derivative transport +namespace: biological_process +def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:1901265 +name: nucleoside phosphate binding +namespace: molecular_function +def: "Binding to nucleoside phosphate." [GOC:TermGenie] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1901266 +name: cephalosporin C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] +synonym: "cephalosporin C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0043645 ! cephalosporin metabolic process + +[Term] +id: GO:1901267 +name: cephalosporin C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] +synonym: "cephalosporin C breakdown" EXACT [GOC:TermGenie] +synonym: "cephalosporin C catabolism" EXACT [GOC:TermGenie] +synonym: "cephalosporin C degradation" EXACT [GOC:TermGenie] +is_a: GO:0030655 ! beta-lactam antibiotic catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046395 ! carboxylic acid catabolic process +is_a: GO:1901266 ! cephalosporin C metabolic process + +[Term] +id: GO:1901268 +name: cephalosporin C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cephalosporin C." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00172] +synonym: "cephalosporin C anabolism" EXACT [GOC:TermGenie] +synonym: "cephalosporin C biosynthesis" EXACT [GOC:TermGenie] +synonym: "cephalosporin C formation" EXACT [GOC:TermGenie] +synonym: "cephalosporin C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043646 ! cephalosporin biosynthetic process +is_a: GO:0046394 ! carboxylic acid biosynthetic process +is_a: GO:1901266 ! cephalosporin C metabolic process + +[Term] +id: GO:1901269 +name: lipooligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] +synonym: "lipooligosaccharide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:1901270 +name: lipooligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] +synonym: "lipooligosaccharide breakdown" EXACT [GOC:TermGenie] +synonym: "lipooligosaccharide catabolism" EXACT [GOC:TermGenie] +synonym: "lipooligosaccharide degradation" EXACT [GOC:TermGenie] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1901269 ! lipooligosaccharide metabolic process + +[Term] +id: GO:1901271 +name: lipooligosaccharide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipooligosaccharide." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00501] +synonym: "lipooligosaccharide anabolism" EXACT [GOC:TermGenie] +synonym: "lipooligosaccharide biosynthesis" EXACT [GOC:TermGenie] +synonym: "lipooligosaccharide formation" EXACT [GOC:TermGenie] +synonym: "lipooligosaccharide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009312 ! oligosaccharide biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:1901269 ! lipooligosaccharide metabolic process + +[Term] +id: GO:1901272 +name: 2-dehydro-3-deoxy-D-gluconic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] +synonym: "2-dehydro-3-deoxy-D-gluconic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:1901273 +name: 2-dehydro-3-deoxy-D-gluconic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] +synonym: "2-dehydro-3-deoxy-D-gluconic acid breakdown" EXACT [GOC:TermGenie] +synonym: "2-dehydro-3-deoxy-D-gluconic acid catabolism" EXACT [GOC:TermGenie] +synonym: "2-dehydro-3-deoxy-D-gluconic acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0046365 ! monosaccharide catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process + +[Term] +id: GO:1901274 +name: 2-dehydro-3-deoxy-D-gluconic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-dehydro-3-deoxy-D-gluconic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00856] +synonym: "2-dehydro-3-deoxy-D-gluconic acid anabolism" EXACT [GOC:TermGenie] +synonym: "2-dehydro-3-deoxy-D-gluconic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "2-dehydro-3-deoxy-D-gluconic acid formation" EXACT [GOC:TermGenie] +synonym: "2-dehydro-3-deoxy-D-gluconic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046364 ! monosaccharide biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901272 ! 2-dehydro-3-deoxy-D-gluconic acid metabolic process + +[Term] +id: GO:1901275 +name: tartrate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] +synonym: "tartrate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1901276 +name: tartrate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] +synonym: "tartrate breakdown" EXACT [GOC:TermGenie] +synonym: "tartrate catabolism" EXACT [GOC:TermGenie] +synonym: "tartrate degradation" EXACT [GOC:TermGenie] +is_a: GO:0009056 ! catabolic process +is_a: GO:1901275 ! tartrate metabolic process + +[Term] +id: GO:1901277 +name: tartrate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tartrate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00839] +synonym: "tartrate anabolism" EXACT [GOC:TermGenie] +synonym: "tartrate biosynthesis" EXACT [GOC:TermGenie] +synonym: "tartrate formation" EXACT [GOC:TermGenie] +synonym: "tartrate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:1901275 ! tartrate metabolic process + +[Term] +id: GO:1901278 +name: D-ribose 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] +synonym: "D-ribose 5-phosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019693 ! ribose phosphate metabolic process + +[Term] +id: GO:1901279 +name: D-ribose 5-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] +synonym: "D-ribose 5-phosphate breakdown" EXACT [GOC:TermGenie] +synonym: "D-ribose 5-phosphate catabolism" EXACT [GOC:TermGenie] +synonym: "D-ribose 5-phosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process + +[Term] +id: GO:1901280 +name: D-ribose 5-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of D-ribose 5-phosphate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00293] +synonym: "D-ribose 5-phosphate anabolism" EXACT [GOC:TermGenie] +synonym: "D-ribose 5-phosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "D-ribose 5-phosphate formation" EXACT [GOC:TermGenie] +synonym: "D-ribose 5-phosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046390 ! ribose phosphate biosynthetic process +is_a: GO:1901278 ! D-ribose 5-phosphate metabolic process + +[Term] +id: GO:1901281 +name: fructoselysine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784] +synonym: "fructosyllysine breakdown" EXACT [GOC:TermGenie] +synonym: "fructosyllysine catabolic process" EXACT [] +synonym: "fructosyllysine catabolism" EXACT [GOC:TermGenie] +synonym: "fructosyllysine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0030392 ! fructosamine catabolic process +is_a: GO:0030393 ! fructoselysine metabolic process + +[Term] +id: GO:1901282 +name: fructoselysine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fructoselysine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00784] +synonym: "fructosyllysine anabolism" EXACT [GOC:TermGenie] +synonym: "fructosyllysine biosynthesis" EXACT [GOC:TermGenie] +synonym: "fructosyllysine biosynthetic process" EXACT [] +synonym: "fructosyllysine formation" EXACT [GOC:TermGenie] +synonym: "fructosyllysine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:0030391 ! fructosamine biosynthetic process +is_a: GO:0030393 ! fructoselysine metabolic process + +[Term] +id: GO:1901283 +name: 5,6,7,8-tetrahydromethanopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] +synonym: "5,6,7,8-tetrahydromethanopterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043648 ! dicarboxylic acid metabolic process +is_a: GO:2001117 ! tetrahydromethanopterin metabolic process + +[Term] +id: GO:1901284 +name: 5,6,7,8-tetrahydromethanopterin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] +synonym: "5,6,7,8-tetrahydromethanopterin breakdown" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydromethanopterin catabolism" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydromethanopterin degradation" EXACT [GOC:TermGenie] +is_a: GO:0042560 ! pteridine-containing compound catabolic process +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process + +[Term] +id: GO:1901285 +name: 5,6,7,8-tetrahydromethanopterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydromethanopterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00065] +synonym: "5,6,7,8-tetrahydromethanopterin anabolism" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydromethanopterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydromethanopterin formation" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydromethanopterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:1901283 ! 5,6,7,8-tetrahydromethanopterin metabolic process +is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process + +[Term] +id: GO:1901286 +name: iron-sulfur-molybdenum cofactor metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] +synonym: "FeMo-co metabolic process" EXACT [GOC:yaf] +synonym: "FeMo-co metabolism" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor metabolic process" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor metabolism" EXACT [GOC:yaf] +synonym: "iron-sulfur-molybdenum cofactor metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1901287 +name: iron-sulfur-molybdenum cofactor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] +synonym: "FeMo-co breakdown" EXACT [GOC:yaf] +synonym: "FeMo-co catabolic process" EXACT [GOC:yaf] +synonym: "FeMo-co catabolism" EXACT [GOC:yaf] +synonym: "FeMo-co degradation" EXACT [GOC:yaf] +synonym: "iron-molybdenum breakdown" EXACT [GOC:yaf] +synonym: "iron-molybdenum catabolic process" EXACT [GOC:yaf] +synonym: "iron-molybdenum catabolism" EXACT [GOC:yaf] +synonym: "iron-molybdenum degradation" EXACT [GOC:yaf] +synonym: "iron-sulfur-molybdenum cofactor breakdown" EXACT [GOC:TermGenie] +synonym: "iron-sulfur-molybdenum cofactor catabolism" EXACT [GOC:TermGenie] +synonym: "iron-sulfur-molybdenum cofactor degradation" EXACT [GOC:TermGenie] +is_a: GO:0009056 ! catabolic process +is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process + +[Term] +id: GO:1901288 +name: iron-sulfur-molybdenum cofactor biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00782] +synonym: "FeMo-co anabolism" EXACT [GOC:yaf] +synonym: "FeMo-co biosynthesis" EXACT [GOC:yaf] +synonym: "FeMo-co biosynthetic process" EXACT [GOC:yaf] +synonym: "FeMo-co formation" EXACT [GOC:yaf] +synonym: "FeMo-co synthesis" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor anabolism" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor biosynthesis" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor biosynthetic process" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor formation" EXACT [GOC:yaf] +synonym: "iron-molybdenum cofactor synthesis" EXACT [GOC:yaf] +synonym: "iron-sulfur-molybdenum cofactor anabolism" EXACT [GOC:TermGenie] +synonym: "iron-sulfur-molybdenum cofactor biosynthesis" EXACT [GOC:TermGenie] +synonym: "iron-sulfur-molybdenum cofactor formation" EXACT [GOC:TermGenie] +synonym: "iron-sulfur-molybdenum cofactor synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:1901286 ! iron-sulfur-molybdenum cofactor metabolic process + +[Term] +id: GO:1901289 +name: succinyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929] +synonym: "succinyl-CoA breakdown" EXACT [GOC:TermGenie] +synonym: "succinyl-CoA catabolism" EXACT [GOC:TermGenie] +synonym: "succinyl-CoA degradation" EXACT [GOC:TermGenie] +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process + +[Term] +id: GO:1901290 +name: succinyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of succinyl-CoA." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00929] +synonym: "succinyl-CoA anabolism" EXACT [GOC:TermGenie] +synonym: "succinyl-CoA biosynthesis" EXACT [GOC:TermGenie] +synonym: "succinyl-CoA formation" EXACT [GOC:TermGenie] +synonym: "succinyl-CoA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006104 ! succinyl-CoA metabolic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process + +[Term] +id: GO:1901291 +name: negative regulation of double-strand break repair via single-strand annealing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via single-strand annealing." [GOC:sart, GOC:TermGenie] +synonym: "down regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] +synonym: "down-regulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] +synonym: "downregulation of double-strand break repair via single-strand annealing" EXACT [GOC:TermGenie] +synonym: "inhibition of double-strand break repair via single-strand annealing" NARROW [GOC:TermGenie] +is_a: GO:2000780 ! negative regulation of double-strand break repair +relationship: negatively_regulates GO:0045002 ! double-strand break repair via single-strand annealing + +[Term] +id: GO:1901292 +name: nucleoside phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside phosphate." [GOC:TermGenie] +synonym: "nucleoside phosphate breakdown" EXACT [GOC:TermGenie] +synonym: "nucleoside phosphate catabolism" EXACT [GOC:TermGenie] +synonym: "nucleoside phosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0006753 ! nucleoside phosphate metabolic process +is_a: GO:0034655 ! nucleobase-containing compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process + +[Term] +id: GO:1901293 +name: nucleoside phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] +synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie] +synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie] +synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006753 ! nucleoside phosphate metabolic process +is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process + +[Term] +id: GO:1901294 +name: obsolete negative regulation of SREBP signaling pathway by negative regulation of DNA binding +namespace: biological_process +def: "OBSOLETE. Negative regulation of DNA binding that results in negative regulation of a SREBP signaling pathway." [GOC:TermGenie, PMID:22017871] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +synonym: "inhibition of SREBP-dependent transcription by blocking DNA binding" EXACT [PMID:22017871] +synonym: "negative regulation of SREBP signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by down regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by down-regulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by downregulation of DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by inhibition of DNA binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by negative regulation of DNA binding" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901295 +name: regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] +is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development +relationship: regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + +[Term] +id: GO:1901296 +name: negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] +is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +is_a: GO:1905067 ! negative regulation of canonical Wnt signaling pathway involved in heart development +relationship: negatively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + +[Term] +id: GO:1901297 +name: positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment." [GOC:BHF, GOC:TermGenie] +synonym: "activation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:signaling] +synonym: "up regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signalling pathway involved in cardiac muscle cell fate commitment" EXACT [GOC:TermGenie] +is_a: GO:1901295 ! regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment +is_a: GO:1905068 ! positive regulation of canonical Wnt signaling pathway involved in heart development +relationship: positively_regulates GO:0061317 ! canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + +[Term] +id: GO:1901298 +name: regulation of hydrogen peroxide-mediated programmed cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] +is_a: GO:0043067 ! regulation of programmed cell death +is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death +relationship: regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death + +[Term] +id: GO:1901299 +name: negative regulation of hydrogen peroxide-mediated programmed cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +synonym: "inhibition of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death +is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death +relationship: negatively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death + +[Term] +id: GO:1901300 +name: positive regulation of hydrogen peroxide-mediated programmed cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death." [GOC:BHF, GOC:TermGenie] +synonym: "activation of hydrogen peroxide-mediated programmed cell death" NARROW [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide-mediated programmed cell death" EXACT [GOC:TermGenie] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death +is_a: GO:1905206 ! positive regulation of hydrogen peroxide-induced cell death +relationship: positively_regulates GO:0010421 ! hydrogen peroxide-mediated programmed cell death + +[Term] +id: GO:1901301 +name: regulation of cargo loading into COPII-coated vesicle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cargo loading into COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885] +synonym: "regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0090110 ! COPII-coated vesicle cargo loading + +[Term] +id: GO:1901303 +name: negative regulation of cargo loading into COPII-coated vesicle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cargo loading into a COPII-coated vesicle." [GOC:lb, GOC:TermGenie, PMID:15899885] +synonym: "down regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of cargo loading into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "inhibition of cargo loading into COPII-coated vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "inhibition of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of COPII vesicle protein binding" NARROW [PMID:15899885] +synonym: "inhibition of protein sorting into COPII-coated vesicles" EXACT [PMID:15899885] +synonym: "negative regulation of cargo loading into COPII vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of cargo selection into COPII-coated vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of COPII coat-cargo complex assembly" RELATED [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:1901301 ! regulation of cargo loading into COPII-coated vesicle +relationship: negatively_regulates GO:0090110 ! COPII-coated vesicle cargo loading + +[Term] +id: GO:1901304 +name: regulation of spermidine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] +synonym: "regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "regulation of spermidine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010967 ! regulation of polyamine biosynthetic process +relationship: regulates GO:0008295 ! spermidine biosynthetic process + +[Term] +id: GO:1901305 +name: negative regulation of spermidine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] +synonym: "down regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of spermidine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of spermidine formation" EXACT [GOC:TermGenie] +synonym: "inhibition of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of spermidine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0033239 ! negative regulation of cellular amine metabolic process +is_a: GO:1901304 ! regulation of spermidine biosynthetic process +relationship: negatively_regulates GO:0008295 ! spermidine biosynthetic process + +[Term] +id: GO:1901307 +name: positive regulation of spermidine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process." [GOC:pm, GOC:TermGenie] +synonym: "activation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "activation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of spermidine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "activation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of spermidine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of spermidine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of spermidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of spermidine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of spermidine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of spermidine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0033240 ! positive regulation of cellular amine metabolic process +is_a: GO:1901304 ! regulation of spermidine biosynthetic process +relationship: positively_regulates GO:0008295 ! spermidine biosynthetic process + +[Term] +id: GO:1901308 +name: regulation of sterol regulatory element binding protein cleavage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie] +synonym: "regulation of SREBP cleavage" EXACT [GOC:TermGenie] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0070613 ! regulation of protein processing +relationship: regulates GO:0035103 ! sterol regulatory element binding protein cleavage + +[Term] +id: GO:1901309 +name: negative regulation of sterol regulatory element binding protein cleavage +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117] +synonym: "down regulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "down regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +synonym: "down-regulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "down-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +synonym: "downregulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "downregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +synonym: "inhibition of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "inhibition of SREBP processing" EXACT [GOC:bf] +synonym: "inhibition of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie] +synonym: "negative regulation of SREBP cleavage" EXACT [GOC:TermGenie] +is_a: GO:0010955 ! negative regulation of protein processing +is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage +is_a: GO:2000639 ! negative regulation of SREBP signaling pathway +relationship: negatively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage + +[Term] +id: GO:1901310 +name: positive regulation of sterol regulatory element binding protein cleavage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sterol regulatory element binding protein cleavage." [GOC:TermGenie, PMID:15899885, PMID:16525117] +synonym: "activation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "activation of sterol regulatory element binding protein cleavage" NARROW [GOC:TermGenie] +synonym: "positive regulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "up regulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "up regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +synonym: "up-regulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "up-regulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +synonym: "upregulation of SREBP cleavage" EXACT [GOC:TermGenie] +synonym: "upregulation of sterol regulatory element binding protein cleavage" EXACT [GOC:TermGenie] +is_a: GO:0010954 ! positive regulation of protein processing +is_a: GO:1901308 ! regulation of sterol regulatory element binding protein cleavage +relationship: positively_regulates GO:0035103 ! sterol regulatory element binding protein cleavage + +[Term] +id: GO:1901311 +name: obsolete regulation of gene expression involved in extracellular matrix organization +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] +comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. +synonym: "regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0010468 + +[Term] +id: GO:1901312 +name: obsolete negative regulation of gene expression involved in extracellular matrix organization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] +comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. +synonym: "down regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "down regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "down regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "down-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "downregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "downregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "inhibition of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "inhibition of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "inhibition of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "negative regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0010629 + +[Term] +id: GO:1901313 +name: obsolete positive regulation of gene expression involved in extracellular matrix organization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of gene expression involved in extracellular matrix organization." [GOC:BHF, GOC:TermGenie] +comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. +synonym: "activation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "activation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "activation of gene expression involved in extracellular matrix organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "positive regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "up regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "up regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "up regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "up-regulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "upregulation of expression of extracellular matrix proteins" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular matrix protein production" RELATED [GOC:TermGenie] +synonym: "upregulation of gene expression involved in extracellular matrix organization" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0010628 + +[Term] +id: GO:1901314 +name: regulation of histone H2A K63-linked ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] +is_a: GO:0033182 ! regulation of histone ubiquitination +is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination +relationship: regulates GO:0070535 ! histone H2A K63-linked ubiquitination + +[Term] +id: GO:1901315 +name: negative regulation of histone H2A K63-linked ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] +synonym: "down regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie] +is_a: GO:0033183 ! negative regulation of histone ubiquitination +is_a: GO:1900045 ! negative regulation of protein K63-linked ubiquitination +is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination +relationship: negatively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination + +[Term] +id: GO:1901316 +name: positive regulation of histone H2A K63-linked ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H2A K63-linked ubiquitination." [GOC:TermGenie] +synonym: "activation of histone H2A K63-linked ubiquitination" NARROW [GOC:TermGenie] +synonym: "up regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H2A K63-linked ubiquitination" EXACT [GOC:TermGenie] +is_a: GO:0033184 ! positive regulation of histone ubiquitination +is_a: GO:1901314 ! regulation of histone H2A K63-linked ubiquitination +is_a: GO:1902523 ! positive regulation of protein K63-linked ubiquitination +relationship: positively_regulates GO:0070535 ! histone H2A K63-linked ubiquitination + +[Term] +id: GO:1901317 +name: regulation of flagellated sperm motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] +synonym: "regulation of sperm motility" BROAD [] +synonym: "regulation of sperm movement" BROAD [GOC:TermGenie] +is_a: GO:0060295 ! regulation of cilium movement involved in cell motility +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0030317 ! flagellated sperm motility + +[Term] +id: GO:1901318 +name: negative regulation of flagellated sperm motility +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:krc, GOC:TermGenie] +synonym: "down regulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "down regulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "down-regulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "down-regulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "downregulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "downregulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "inhibition of sperm motility" NARROW [GOC:TermGenie] +synonym: "inhibition of sperm movement" BROAD [GOC:TermGenie] +synonym: "negative regulation of sperm motility" BROAD [] +synonym: "negative regulation of sperm movement" BROAD [GOC:TermGenie] +is_a: GO:0003354 ! negative regulation of cilium movement +is_a: GO:1901317 ! regulation of flagellated sperm motility +is_a: GO:1902020 ! negative regulation of cilium-dependent cell motility +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0030317 ! flagellated sperm motility + +[Term] +id: GO:1901319 +name: positive regulation of trehalose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of trehalose catabolic process." [GOC:TermGenie] +synonym: "activation of mycose catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of mycose catabolism" EXACT [GOC:TermGenie] +synonym: "activation of mykose catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of mykose catabolism" EXACT [GOC:TermGenie] +synonym: "activation of trehalose breakdown" EXACT [GOC:TermGenie] +synonym: "activation of trehalose catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of trehalose catabolism" EXACT [GOC:TermGenie] +synonym: "activation of trehalose degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of mycose catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of mycose catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of mykose catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of mykose catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of trehalose breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of trehalose catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of trehalose degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of mycose catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of mycose catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mykose catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of mykose catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of trehalose breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of trehalose catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of trehalose catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of trehalose degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mycose catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mycose catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mykose catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mykose catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of trehalose breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of trehalose catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of trehalose catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of trehalose degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of mycose catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mycose catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mykose catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mykose catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of trehalose breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of trehalose catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of trehalose catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of trehalose degradation" EXACT [GOC:TermGenie] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:0090062 ! regulation of trehalose metabolic process +relationship: positively_regulates GO:0005993 ! trehalose catabolic process + +[Term] +id: GO:1901320 +name: negative regulation of heart induction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart induction." [GOC:TermGenie] +synonym: "down regulation of heart induction" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart induction" EXACT [GOC:TermGenie] +synonym: "downregulation of heart induction" EXACT [GOC:TermGenie] +synonym: "inhibition of heart induction" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0090381 ! regulation of heart induction +relationship: negatively_regulates GO:0003129 ! heart induction + +[Term] +id: GO:1901321 +name: positive regulation of heart induction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heart induction." [GOC:TermGenie] +synonym: "activation of heart induction" NARROW [GOC:TermGenie] +synonym: "up regulation of heart induction" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart induction" EXACT [GOC:TermGenie] +synonym: "upregulation of heart induction" EXACT [GOC:TermGenie] +is_a: GO:0090381 ! regulation of heart induction +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +relationship: positively_regulates GO:0003129 ! heart induction + +[Term] +id: GO:1901322 +name: response to chloramphenicol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901323 +name: response to erythromycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901324 +name: response to trichodermin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether + +[Term] +id: GO:1901325 +name: response to antimycin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901326 +name: response to tetracycline +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus." [GOC:TermGenie] +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1901327 +name: response to tacrolimus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus." [GOC:TermGenie] +synonym: "response to FK506" EXACT [CHEBI:61057] +synonym: "response to tacrolimus hydrate" EXACT [CHEBI:61057] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1901328 +name: response to cytochalasin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901329 +name: regulation of odontoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0071895 ! odontoblast differentiation + +[Term] +id: GO:1901330 +name: negative regulation of odontoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] +synonym: "down regulation of odontoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of odontoblast differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of odontoblast differentiation" NARROW [GOC:TermGenie] +is_a: GO:0002085 ! inhibition of neuroepithelial cell differentiation +is_a: GO:1901329 ! regulation of odontoblast differentiation +relationship: negatively_regulates GO:0071895 ! odontoblast differentiation + +[Term] +id: GO:1901331 +name: positive regulation of odontoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of odontoblast differentiation." [GOC:TermGenie] +synonym: "activation of odontoblast differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of odontoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of odontoblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of odontoblast differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901329 ! regulation of odontoblast differentiation +is_a: GO:1902913 ! positive regulation of neuroepithelial cell differentiation +relationship: positively_regulates GO:0071895 ! odontoblast differentiation + +[Term] +id: GO:1901332 +name: negative regulation of lateral root development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral root development." [GOC:TermGenie] +synonym: "down regulation of lateral root development" EXACT [GOC:TermGenie] +synonym: "down-regulation of lateral root development" EXACT [GOC:TermGenie] +synonym: "downregulation of lateral root development" EXACT [GOC:TermGenie] +synonym: "inhibition of lateral root development" NARROW [GOC:TermGenie] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:2000023 ! regulation of lateral root development +relationship: negatively_regulates GO:0048527 ! lateral root development + +[Term] +id: GO:1901333 +name: positive regulation of lateral root development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral root development." [GOC:TermGenie] +synonym: "activation of lateral root development" NARROW [GOC:TermGenie] +synonym: "up regulation of lateral root development" EXACT [GOC:TermGenie] +synonym: "up-regulation of lateral root development" EXACT [GOC:TermGenie] +synonym: "upregulation of lateral root development" EXACT [GOC:TermGenie] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:2000023 ! regulation of lateral root development +relationship: positively_regulates GO:0048527 ! lateral root development + +[Term] +id: GO:1901334 +name: lactone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lactone." [GOC:TermGenie] +synonym: "lactone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901335 +name: lactone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactone." [GOC:TermGenie] +synonym: "lactone breakdown" EXACT [GOC:TermGenie] +synonym: "lactone catabolism" EXACT [GOC:TermGenie] +synonym: "lactone degradation" EXACT [GOC:TermGenie] +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901334 ! lactone metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process + +[Term] +id: GO:1901336 +name: lactone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lactone." [GOC:TermGenie] +synonym: "lactone anabolism" EXACT [GOC:TermGenie] +synonym: "lactone biosynthesis" EXACT [GOC:TermGenie] +synonym: "lactone formation" EXACT [GOC:TermGenie] +synonym: "lactone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901334 ! lactone metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process + +[Term] +id: GO:1901337 +name: thioester transport +namespace: biological_process +def: "The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:1901338 +name: catecholamine binding +namespace: molecular_function +def: "Binding to catecholamine." [GOC:TermGenie] +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:1901339 +name: regulation of store-operated calcium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1901340 +name: negative regulation of store-operated calcium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] +synonym: "down regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of store-operated calcium channel activity" NARROW [GOC:TermGenie] +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:1901339 ! regulation of store-operated calcium channel activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1901341 +name: positive regulation of store-operated calcium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity." [GOC:TermGenie] +synonym: "activation of store-operated calcium channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of store-operated calcium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:1901339 ! regulation of store-operated calcium channel activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1901342 +name: regulation of vasculature development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vasculature development." [GOC:TermGenie] +synonym: "regulation of vascular system development" RELATED [GOC:TermGenie] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0001944 ! vasculature development + +[Term] +id: GO:1901343 +name: negative regulation of vasculature development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development." [GOC:TermGenie] +synonym: "down regulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "down regulation of vasculature development" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "down-regulation of vasculature development" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "downregulation of vasculature development" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular system development" RELATED [GOC:TermGenie] +synonym: "inhibition of vasculature development" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular system development" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901342 ! regulation of vasculature development +relationship: negatively_regulates GO:0001944 ! vasculature development + +[Term] +id: GO:1901344 +name: response to leptomycin B +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1901345 +name: response to L-thialysine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus." [GOC:TermGenie] +synonym: "response to thialysine" BROAD [GOC:mah] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1901346 +name: negative regulation of vasculature development involved in avascular cornea development in camera-type eye +namespace: biological_process +def: "Any negative regulation of vasculature development that is involved in developing an avascular cornea of a camera-type eye." [GOC:TermGenie, GOC:uh, PMID:16849433, PMID:17051153] +synonym: "down regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] +synonym: "down regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] +synonym: "down regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] +synonym: "down regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] +synonym: "down-regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] +synonym: "down-regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] +synonym: "down-regulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] +synonym: "downregulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] +synonym: "downregulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] +synonym: "downregulation of vasculature development involved in avascular cornea development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] +synonym: "inhibition of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] +synonym: "inhibition of vasculature development involved in avascular cornea development" NARROW [GOC:TermGenie] +synonym: "inhibition of vasculature development involved in avascular cornea development in camera-type eye" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular system development involved in avascular cornea development" RELATED [GOC:TermGenie] +synonym: "negative regulation of vascular system development involved in avascular cornea development in camera-type eye" RELATED [GOC:TermGenie] +synonym: "negative regulation of vasculature development involved in avascular cornea development" EXACT [GOC:TermGenie] +is_a: GO:1901343 ! negative regulation of vasculature development +relationship: part_of GO:0036331 ! avascular cornea development in camera-type eye + +[Term] +id: GO:1901347 +name: negative regulation of secondary cell wall biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie] +synonym: "down regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "down regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "down regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "down regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "down-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "down-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "down-regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "down-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "downregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "downregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "downregulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "downregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "inhibition of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "inhibition of secondary cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "inhibition of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "inhibition of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "negative regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "negative regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "negative regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "negative regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +is_a: GO:1903339 ! negative regulation of cell wall organization or biogenesis +is_a: GO:2000652 ! regulation of secondary cell wall biogenesis +relationship: negatively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis + +[Term] +id: GO:1901348 +name: positive regulation of secondary cell wall biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secondary cell wall biogenesis." [GOC:TermGenie] +synonym: "activation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "activation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "activation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "activation of secondary cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "activation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "activation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "positive regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "positive regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "positive regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "positive regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "up regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "up regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "up regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "up regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "up-regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "up-regulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "up-regulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "up-regulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +synonym: "upregulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of plant-type secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of secondary cell wall anabolism" BROAD [GOC:TermGenie] +synonym: "upregulation of secondary cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of secondary cell wall biosynthetic process" BROAD [GOC:TermGenie] +synonym: "upregulation of secondary cell wall formation" BROAD [GOC:TermGenie] +synonym: "upregulation of secondary cell wall synthesis" BROAD [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:1903340 ! positive regulation of cell wall organization or biogenesis +is_a: GO:2000652 ! regulation of secondary cell wall biogenesis +relationship: positively_regulates GO:0009834 ! plant-type secondary cell wall biogenesis + +[Term] +id: GO:1901349 +name: glucosinolate transport +namespace: biological_process +def: "The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] +is_a: GO:0006820 ! anion transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0072348 ! sulfur compound transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:1901350 +name: obsolete cell-cell signaling involved in cell-cell junction organization +namespace: biological_process +def: "OBSOLETE. Any cell-cell signaling that is involved in cell-cell junction organization." [GOC:TermGenie] +comment: The reasons for obsoletion are that: (1) the term was created in 2012 and it had been used for only 1 NAS annotation (UniProt) since then; and (2)\nit can be represented as a GO-CAM. +synonym: "cell-cell signaling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "cell-cell signaling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie] +synonym: "cell-cell signaling involved in cell-cell junction organisation" EXACT [GOC:TermGenie] +synonym: "cell-cell signaling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "cell-cell signalling involved in cell-cell junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "cell-cell signalling involved in cell-cell junction biogenesis" RELATED [GOC:TermGenie] +synonym: "cell-cell signalling involved in cell-cell junction organisation" EXACT [GOC:TermGenie] +synonym: "cell-cell signalling involved in cell-cell junction organization" EXACT [GOC:TermGenie] +synonym: "cell-cell signalling involved in intercellular junction assembly and maintenance" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901351 +name: regulation of phosphatidylglycerol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] +synonym: "regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +relationship: regulates GO:0006655 ! phosphatidylglycerol biosynthetic process + +[Term] +id: GO:1901352 +name: negative regulation of phosphatidylglycerol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] +synonym: "down regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylglycerol formation" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process +relationship: negatively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process + +[Term] +id: GO:1901353 +name: positive regulation of phosphatidylglycerol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylglycerol biosynthetic process." [GOC:dgf, GOC:TermGenie, PMID:12869188] +synonym: "activation of phosphatidylglycerol anabolism" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylglycerol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylglycerol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylglycerol formation" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylglycerol synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylglycerol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylglycerol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylglycerol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylglycerol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylglycerol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +is_a: GO:1901351 ! regulation of phosphatidylglycerol biosynthetic process +relationship: positively_regulates GO:0006655 ! phosphatidylglycerol biosynthetic process + +[Term] +id: GO:1901354 +name: response to L-canavanine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus." [GOC:TermGenie] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1901355 +name: response to rapamycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1901356 +name: beta-D-galactofuranose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-D-galactofuranose." [GOC:di, GOC:TermGenie] +synonym: "beta-D-galactofuranose metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006012 ! galactose metabolic process + +[Term] +id: GO:1901357 +name: beta-D-galactofuranose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-D-galactofuranose." [GOC:di, GOC:TermGenie] +synonym: "beta-D-galactofuranose breakdown" EXACT [GOC:TermGenie] +synonym: "beta-D-galactofuranose catabolism" EXACT [GOC:TermGenie] +synonym: "beta-D-galactofuranose degradation" EXACT [GOC:TermGenie] +is_a: GO:0019388 ! galactose catabolic process +is_a: GO:1901356 ! beta-D-galactofuranose metabolic process + +[Term] +id: GO:1901358 +name: beta-D-galactofuranose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-D-galactofuranose." [GOC:di, GOC:TermGenie] +synonym: "beta-D-galactofuranose anabolism" EXACT [GOC:TermGenie] +synonym: "beta-D-galactofuranose biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-D-galactofuranose formation" EXACT [GOC:TermGenie] +synonym: "beta-D-galactofuranose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046369 ! galactose biosynthetic process +is_a: GO:1901356 ! beta-D-galactofuranose metabolic process + +[Term] +id: GO:1901359 +name: tungstate binding +namespace: molecular_function +def: "Binding to tungstate." [GOC:TermGenie] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:1901360 +name: organic cyclic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] +synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901361 +name: organic cyclic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie] +synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901362 +name: organic cyclic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] +synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] +synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901363 +name: heterocyclic compound binding +namespace: molecular_function +def: "Binding to heterocyclic compound." [GOC:TermGenie] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1901364 +name: funalenone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving funalenone." [GOC:di, GOC:TermGenie] +synonym: "funalenone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:1901365 +name: funalenone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of funalenone." [GOC:di, GOC:TermGenie] +synonym: "funalenone breakdown" EXACT [GOC:TermGenie] +synonym: "funalenone catabolism" EXACT [GOC:TermGenie] +synonym: "funalenone degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901364 ! funalenone metabolic process + +[Term] +id: GO:1901366 +name: funalenone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of funalenone." [GOC:di, GOC:TermGenie] +synonym: "funalenone anabolism" EXACT [GOC:TermGenie] +synonym: "funalenone biosynthesis" EXACT [GOC:TermGenie] +synonym: "funalenone formation" EXACT [GOC:TermGenie] +synonym: "funalenone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901364 ! funalenone metabolic process + +[Term] +id: GO:1901367 +name: response to L-cysteine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus." [GOC:TermGenie] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1901369 +name: cyclic 2,3-bisphospho-D-glycerate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid." [GOC:bf, GOC:crds, GOC:TermGenie, PMID:2226838] +synonym: "cDPG biosynthesis" EXACT [PMID:2226838] +synonym: "cyclic 2,3-bisphospho-D-glyceric acid anabolism" EXACT [GOC:TermGenie] +synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process" EXACT [CHEBI:28699] +synonym: "cyclic 2,3-bisphospho-D-glyceric acid formation" EXACT [GOC:TermGenie] +synonym: "cyclic 2,3-bisphospho-D-glyceric acid synthesis" EXACT [GOC:TermGenie] +synonym: "cyclic 2,3-diphosphoglycerate biosynthesis" EXACT [CHEBI:28699] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process + +[Term] +id: GO:1901370 +name: response to glutathione +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus." [GOC:TermGenie] +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:1901371 +name: regulation of leaf morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leaf morphogenesis." [GOC:TermGenie] +is_a: GO:1900618 ! regulation of shoot system morphogenesis +is_a: GO:1905421 ! regulation of plant organ morphogenesis +relationship: regulates GO:0009965 ! leaf morphogenesis + +[Term] +id: GO:1901372 +name: obsolete trehalose biosynthetic process involved in ascospore formation +namespace: biological_process +def: "OBSOLETE. Any trehalose biosynthetic process that is involved in ascospore formation." [GOC:TermGenie] +comment: This term was obsoleted because it does not represent a specific pathway. +synonym: "mycose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "mycose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "mycose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "mycose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "mykose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "mykose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "mykose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "mykose biosynthetic process involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "trehalose anabolism involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "trehalose anabolism involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "trehalose biosynthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "trehalose biosynthesis involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "trehalose biosynthetic process involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "trehalose formation involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "trehalose formation involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "trehalose synthesis involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "trehalose synthesis involved in ascospore formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901373 +name: lipid hydroperoxide transport +namespace: biological_process +def: "The directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] +is_a: GO:0006869 ! lipid transport + +[Term] +id: GO:1901374 +name: acetate ester transport +namespace: biological_process +def: "The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:1901375 +name: acetate ester transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an acetate ester from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901376 +name: organic heteropentacyclic compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic heteropentacyclic compound." [GOC:TermGenie] +synonym: "organic heteropentacyclic compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901377 +name: organic heteropentacyclic compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic heteropentacyclic compound." [GOC:TermGenie] +synonym: "organic heteropentacyclic compound breakdown" EXACT [GOC:TermGenie] +synonym: "organic heteropentacyclic compound catabolism" EXACT [GOC:TermGenie] +synonym: "organic heteropentacyclic compound degradation" EXACT [GOC:TermGenie] +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:1901378 +name: organic heteropentacyclic compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic heteropentacyclic compound." [GOC:TermGenie] +synonym: "organic heteropentacyclic compound anabolism" EXACT [GOC:TermGenie] +synonym: "organic heteropentacyclic compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "organic heteropentacyclic compound formation" EXACT [GOC:TermGenie] +synonym: "organic heteropentacyclic compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:1901379 +name: regulation of potassium ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of potassium ion membrane transport" EXACT [] +is_a: GO:0043266 ! regulation of potassium ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0071805 ! potassium ion transmembrane transport + +[Term] +id: GO:1901380 +name: negative regulation of potassium ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of potassium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of potassium ion membrane transport" EXACT [] +is_a: GO:0043267 ! negative regulation of potassium ion transport +is_a: GO:1901379 ! regulation of potassium ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0071805 ! potassium ion transmembrane transport + +[Term] +id: GO:1901381 +name: positive regulation of potassium ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport." [GOC:BHF, GOC:TermGenie] +synonym: "activation of potassium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of potassium ion membrane transport" EXACT [] +synonym: "up regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium ion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0043268 ! positive regulation of potassium ion transport +is_a: GO:1901379 ! regulation of potassium ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0071805 ! potassium ion transmembrane transport + +[Term] +id: GO:1901382 +name: regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0097360 ! chorionic trophoblast cell proliferation + +[Term] +id: GO:1901383 +name: negative regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation +relationship: negatively_regulates GO:0097360 ! chorionic trophoblast cell proliferation + +[Term] +id: GO:1901384 +name: positive regulation of chorionic trophoblast cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of chorionic trophoblast cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of chorionic trophoblast cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1901382 ! regulation of chorionic trophoblast cell proliferation +relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proliferation + +[Term] +id: GO:1901385 +name: regulation of voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1901386 +name: negative regulation of voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "down regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "down regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "down regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "down-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "down-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "down-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "downregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "downregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "downregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "downregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "inhibition of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "inhibition of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "inhibition of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "negative regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "negative regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "negative regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1901387 +name: positive regulation of voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated calcium channel activity." [GOC:BHF, GOC:TermGenie] +synonym: "activation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "activation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "activation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of voltage-gated calcium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "activation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "positive regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "positive regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "positive regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "up regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "up regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "up regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "up-regulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "up-regulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "up-regulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +synonym: "upregulation of depolarization-activated calcium channel" BROAD [GOC:TermGenie] +synonym: "upregulation of depolarization-activated voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of depolarization-activated voltage-gated calcium channel" EXACT [GOC:TermGenie] +synonym: "upregulation of depolarization-activated voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of dihydropyridine-sensitive calcium channel activity" NARROW [GOC:TermGenie] +synonym: "upregulation of voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated calcium ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-sensitive calcium channel" EXACT [GOC:TermGenie] +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1901388 +name: regulation of transforming growth factor beta activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] +synonym: "regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFbeta activation" EXACT [GOC:TermGenie] +is_a: GO:0071634 ! regulation of transforming growth factor beta production +relationship: regulates GO:0036363 ! transforming growth factor beta activation + +[Term] +id: GO:1901389 +name: negative regulation of transforming growth factor beta activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] +synonym: "down regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "down regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +synonym: "downregulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "downregulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "downregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +synonym: "inhibition of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "inhibition of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFB activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "inhibition of transforming growth factor beta activation" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFbeta activation" EXACT [GOC:TermGenie] +is_a: GO:0071635 ! negative regulation of transforming growth factor beta production +is_a: GO:1901388 ! regulation of transforming growth factor beta activation +relationship: negatively_regulates GO:0036363 ! transforming growth factor beta activation + +[Term] +id: GO:1901390 +name: positive regulation of transforming growth factor beta activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation." [GOC:sl, GOC:TermGenie] +synonym: "activation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "activation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "activation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "activation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "activation of transforming growth factor beta activation" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "up regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "up regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +synonym: "upregulation of L-TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "upregulation of latent TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGF-B activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGF-beta activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFB activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFbeta activation" EXACT [GOC:TermGenie] +synonym: "upregulation of transforming growth factor beta activation" EXACT [GOC:TermGenie] +is_a: GO:0071636 ! positive regulation of transforming growth factor beta production +is_a: GO:1901388 ! regulation of transforming growth factor beta activation +relationship: positively_regulates GO:0036363 ! transforming growth factor beta activation + +[Term] +id: GO:1901392 +name: regulation of transforming growth factor beta1 activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] +synonym: "regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +is_a: GO:1901388 ! regulation of transforming growth factor beta activation +relationship: regulates GO:0036364 ! transforming growth factor beta1 activation + +[Term] +id: GO:1901393 +name: negative regulation of transforming growth factor beta1 activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] +synonym: "down regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of transforming growth factor beta1 activation" NARROW [GOC:TermGenie] +synonym: "inhibition of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +is_a: GO:0032911 ! negative regulation of transforming growth factor beta1 production +is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation +is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation +relationship: negatively_regulates GO:0036364 ! transforming growth factor beta1 activation + +[Term] +id: GO:1901394 +name: positive regulation of transforming growth factor beta1 activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation." [GOC:sl, GOC:TermGenie] +synonym: "activation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "activation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "activation of transforming growth factor beta1 activation" NARROW [GOC:TermGenie] +synonym: "activation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of L-TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of latent-TGF-beta1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGF-beta 1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFB1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFbeta 1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of transforming growth factor beta1 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of transforming growth factor-beta1 activation" EXACT [GOC:TermGenie] +is_a: GO:0032914 ! positive regulation of transforming growth factor beta1 production +is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation +is_a: GO:1901392 ! regulation of transforming growth factor beta1 activation +relationship: positively_regulates GO:0036364 ! transforming growth factor beta1 activation + +[Term] +id: GO:1901395 +name: regulation of transforming growth factor beta2 activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] +synonym: "regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +is_a: GO:0032909 ! regulation of transforming growth factor beta2 production +is_a: GO:1901388 ! regulation of transforming growth factor beta activation +relationship: regulates GO:0036365 ! transforming growth factor beta2 activation + +[Term] +id: GO:1901396 +name: negative regulation of transforming growth factor beta2 activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] +synonym: "down regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of transforming growth factor beta2 activation" NARROW [GOC:TermGenie] +synonym: "negative regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +is_a: GO:0032912 ! negative regulation of transforming growth factor beta2 production +is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation +is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation +relationship: negatively_regulates GO:0036365 ! transforming growth factor beta2 activation + +[Term] +id: GO:1901397 +name: positive regulation of transforming growth factor beta2 activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation." [GOC:sl, GOC:TermGenie] +synonym: "activation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "activation of transforming growth factor beta2 activation" NARROW [GOC:TermGenie] +synonym: "positive regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGF-beta 2 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFB2 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFbeta 2 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of transforming growth factor beta2 activation" EXACT [GOC:TermGenie] +is_a: GO:0032915 ! positive regulation of transforming growth factor beta2 production +is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation +is_a: GO:1901395 ! regulation of transforming growth factor beta2 activation +relationship: positively_regulates GO:0036365 ! transforming growth factor beta2 activation + +[Term] +id: GO:1901398 +name: regulation of transforming growth factor beta3 activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] +synonym: "regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +is_a: GO:0032910 ! regulation of transforming growth factor beta3 production +is_a: GO:1901388 ! regulation of transforming growth factor beta activation +relationship: regulates GO:0036366 ! transforming growth factor beta3 activation + +[Term] +id: GO:1901399 +name: negative regulation of transforming growth factor beta3 activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] +synonym: "down regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "down regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "downregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "inhibition of transforming growth factor beta3 activation" NARROW [GOC:TermGenie] +synonym: "negative regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +is_a: GO:0032913 ! negative regulation of transforming growth factor beta3 production +is_a: GO:1901389 ! negative regulation of transforming growth factor beta activation +is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation +relationship: negatively_regulates GO:0036366 ! transforming growth factor beta3 activation + +[Term] +id: GO:1901400 +name: positive regulation of transforming growth factor beta3 activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation." [GOC:sl, GOC:TermGenie] +synonym: "activation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "activation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "activation of transforming growth factor beta3 activation" NARROW [GOC:TermGenie] +synonym: "positive regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "up regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGF-beta 3 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFB3 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of TGFbeta 3 activation" EXACT [GOC:TermGenie] +synonym: "upregulation of transforming growth factor beta3 activation" EXACT [GOC:TermGenie] +is_a: GO:0032916 ! positive regulation of transforming growth factor beta3 production +is_a: GO:1901390 ! positive regulation of transforming growth factor beta activation +is_a: GO:1901398 ! regulation of transforming growth factor beta3 activation +relationship: positively_regulates GO:0036366 ! transforming growth factor beta3 activation + +[Term] +id: GO:1901401 +name: regulation of tetrapyrrole metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:1901402 +name: negative regulation of tetrapyrrole metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: negatively_regulates GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:1901403 +name: positive regulation of tetrapyrrole metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: positively_regulates GO:0033013 ! tetrapyrrole metabolic process + +[Term] +id: GO:1901404 +name: regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: regulates GO:0033015 ! tetrapyrrole catabolic process + +[Term] +id: GO:1901405 +name: negative regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process +is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process +relationship: negatively_regulates GO:0033015 ! tetrapyrrole catabolic process + +[Term] +id: GO:1901406 +name: positive regulation of tetrapyrrole catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process +is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process +relationship: positively_regulates GO:0033015 ! tetrapyrrole catabolic process + +[Term] +id: GO:1901407 +name: regulation of phosphorylation of RNA polymerase II C-terminal domain +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] +synonym: "regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +is_a: GO:0001932 ! regulation of protein phosphorylation +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +relationship: regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain + +[Term] +id: GO:1901408 +name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] +synonym: "down regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "down-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "down-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "downregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "downregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "downregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "downregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "inhibition of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "inhibition of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "inhibition of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "inhibition of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] +synonym: "negative regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "negative regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "negative regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "negative regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain +relationship: negatively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain + +[Term] +id: GO:1901409 +name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain." [GOC:TermGenie] +synonym: "activation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "activation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "activation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "activation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "activation of phosphorylation of RNA polymerase II C-terminal domain" NARROW [GOC:TermGenie] +synonym: "positive regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "positive regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "up regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "up-regulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up-regulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "upregulation of CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "upregulation of generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "upregulation of generation of II(0) form of RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:TermGenie] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain +relationship: positively_regulates GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain + +[Term] +id: GO:1901410 +name: regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +is_a: GO:2000211 ! regulation of glutamate metabolic process +relationship: regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate + +[Term] +id: GO:1901411 +name: negative regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate +is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process +is_a: GO:2000212 ! negative regulation of glutamate metabolic process +relationship: negatively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate + +[Term] +id: GO:1901412 +name: positive regulation of tetrapyrrole biosynthetic process from glutamate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glutamate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthetic process from glutamate" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole anabolism from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthesis from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthetic process from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole formation from glutamate" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole synthesis from glutamate" EXACT [GOC:TermGenie] +is_a: GO:1901410 ! regulation of tetrapyrrole biosynthetic process from glutamate +is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process +is_a: GO:2000213 ! positive regulation of glutamate metabolic process +relationship: positively_regulates GO:0033526 ! tetrapyrrole biosynthetic process from glutamate + +[Term] +id: GO:1901413 +name: regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +relationship: regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA + +[Term] +id: GO:1901414 +name: negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA +is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process +relationship: negatively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA + +[Term] +id: GO:1901415 +name: positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process from glycine and succinyl-CoA." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole anabolism from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole formation from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole synthesis from glycine and succinyl-CoA" EXACT [GOC:TermGenie] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process +is_a: GO:1901413 ! regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA +is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process +relationship: positively_regulates GO:0033527 ! tetrapyrrole biosynthetic process from glycine and succinyl-CoA + +[Term] +id: GO:1901416 +name: regulation of response to ethanol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1901419 ! regulation of response to alcohol +relationship: regulates GO:0045471 ! response to ethanol + +[Term] +id: GO:1901417 +name: negative regulation of response to ethanol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to ethanol" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to ethanol" EXACT [GOC:TermGenie] +synonym: "downregulation of response to ethanol" EXACT [GOC:TermGenie] +synonym: "inhibition of response to ethanol" NARROW [GOC:TermGenie] +is_a: GO:1901416 ! regulation of response to ethanol +is_a: GO:1901420 ! negative regulation of response to alcohol +relationship: negatively_regulates GO:0045471 ! response to ethanol + +[Term] +id: GO:1901418 +name: positive regulation of response to ethanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to ethanol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to ethanol" NARROW [GOC:TermGenie] +synonym: "up regulation of response to ethanol" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to ethanol" EXACT [GOC:TermGenie] +synonym: "upregulation of response to ethanol" EXACT [GOC:TermGenie] +is_a: GO:1901416 ! regulation of response to ethanol +is_a: GO:1901421 ! positive regulation of response to alcohol +relationship: positively_regulates GO:0045471 ! response to ethanol + +[Term] +id: GO:1901419 +name: regulation of response to alcohol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0097305 ! response to alcohol + +[Term] +id: GO:1901420 +name: negative regulation of response to alcohol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to alcohol" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to alcohol" EXACT [GOC:TermGenie] +synonym: "downregulation of response to alcohol" EXACT [GOC:TermGenie] +synonym: "inhibition of response to alcohol" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901419 ! regulation of response to alcohol +relationship: negatively_regulates GO:0097305 ! response to alcohol + +[Term] +id: GO:1901421 +name: positive regulation of response to alcohol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to alcohol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to alcohol" NARROW [GOC:TermGenie] +synonym: "up regulation of response to alcohol" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to alcohol" EXACT [GOC:TermGenie] +synonym: "upregulation of response to alcohol" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901419 ! regulation of response to alcohol +relationship: positively_regulates GO:0097305 ! response to alcohol + +[Term] +id: GO:1901422 +name: response to butan-1-ol +namespace: biological_process +alt_id: GO:1990336 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie, PMID:24014527] +synonym: "process resulting in tolerance to butan-1-ol" NARROW [] +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:1901423 +name: response to benzene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzene stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1901424 +name: response to toluene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toluene stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1901425 +name: response to formic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formic acid stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901426 +name: response to furfural +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a furfural stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901427 +name: response to propan-1-ol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a propan-1-ol stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:1901428 +name: regulation of syringal lignin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] +synonym: "regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901141 ! regulation of lignin biosynthetic process +relationship: regulates GO:1901066 ! syringal lignin biosynthetic process + +[Term] +id: GO:1901429 +name: negative regulation of syringal lignin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process +relationship: negatively_regulates GO:1901066 ! syringal lignin biosynthetic process + +[Term] +id: GO:1901430 +name: positive regulation of syringal lignin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of syringal lignin biosynthetic process." [GOC:TermGenie] +synonym: "activation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of S-lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process +is_a: GO:1901428 ! regulation of syringal lignin biosynthetic process +relationship: positively_regulates GO:1901066 ! syringal lignin biosynthetic process + +[Term] +id: GO:1901431 +name: regulation of response to cycloalkane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0014071 ! response to cycloalkane + +[Term] +id: GO:1901432 +name: negative regulation of response to cycloalkane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to cycloalkane" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to cycloalkane" EXACT [GOC:TermGenie] +synonym: "downregulation of response to cycloalkane" EXACT [GOC:TermGenie] +synonym: "inhibition of response to cycloalkane" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901431 ! regulation of response to cycloalkane +relationship: negatively_regulates GO:0014071 ! response to cycloalkane + +[Term] +id: GO:1901433 +name: positive regulation of response to cycloalkane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to cycloalkane." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to cycloalkane" NARROW [GOC:TermGenie] +synonym: "up regulation of response to cycloalkane" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to cycloalkane" EXACT [GOC:TermGenie] +synonym: "upregulation of response to cycloalkane" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901431 ! regulation of response to cycloalkane +relationship: positively_regulates GO:0014071 ! response to cycloalkane + +[Term] +id: GO:1901434 +name: regulation of toluene catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of toluene degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:1901437 ! regulation of toluene metabolic process +relationship: regulates GO:0042203 ! toluene catabolic process + +[Term] +id: GO:1901435 +name: negative regulation of toluene catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of toluene catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of toluene degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of toluene degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:1901434 ! regulation of toluene catabolic process +is_a: GO:1901438 ! negative regulation of toluene metabolic process +relationship: negatively_regulates GO:0042203 ! toluene catabolic process + +[Term] +id: GO:1901436 +name: positive regulation of toluene catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of toluene catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "activation of toluene catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "activation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1901434 ! regulation of toluene catabolic process +is_a: GO:1901439 ! positive regulation of toluene metabolic process +relationship: positively_regulates GO:0042203 ! toluene catabolic process + +[Term] +id: GO:1901437 +name: regulation of toluene metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of toluene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0018970 ! toluene metabolic process + +[Term] +id: GO:1901438 +name: negative regulation of toluene metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of toluene metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of toluene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1901437 ! regulation of toluene metabolic process +relationship: negatively_regulates GO:0018970 ! toluene metabolic process + +[Term] +id: GO:1901439 +name: positive regulation of toluene metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of toluene metabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "activation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "activation of toluene metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of toluene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of methylbenzene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methylbenzene metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of toluene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1901437 ! regulation of toluene metabolic process +relationship: positively_regulates GO:0018970 ! toluene metabolic process + +[Term] +id: GO:1901440 +name: poly(hydroxyalkanoate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901441 +name: poly(hydroxyalkanoate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate)." [GOC:mengo_curators, GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) anabolism" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) formation" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901442 +name: regulation of response to furfural +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:1901426 ! response to furfural + +[Term] +id: GO:1901443 +name: negative regulation of response to furfural +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to furfural" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to furfural" EXACT [GOC:TermGenie] +synonym: "downregulation of response to furfural" EXACT [GOC:TermGenie] +synonym: "inhibition of response to furfural" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901442 ! regulation of response to furfural +relationship: negatively_regulates GO:1901426 ! response to furfural + +[Term] +id: GO:1901444 +name: positive regulation of response to furfural +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to furfural." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to furfural" NARROW [GOC:TermGenie] +synonym: "up regulation of response to furfural" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to furfural" EXACT [GOC:TermGenie] +synonym: "upregulation of response to furfural" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901442 ! regulation of response to furfural +relationship: positively_regulates GO:1901426 ! response to furfural + +[Term] +id: GO:1901445 +name: regulation of response to propan-1-ol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1901419 ! regulation of response to alcohol +relationship: regulates GO:1901427 ! response to propan-1-ol + +[Term] +id: GO:1901446 +name: negative regulation of response to propan-1-ol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to propan-1-ol" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to propan-1-ol" EXACT [GOC:TermGenie] +synonym: "downregulation of response to propan-1-ol" EXACT [GOC:TermGenie] +synonym: "inhibition of response to propan-1-ol" NARROW [GOC:TermGenie] +is_a: GO:1901420 ! negative regulation of response to alcohol +is_a: GO:1901445 ! regulation of response to propan-1-ol +relationship: negatively_regulates GO:1901427 ! response to propan-1-ol + +[Term] +id: GO:1901447 +name: positive regulation of response to propan-1-ol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to propan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to propan-1-ol" NARROW [GOC:TermGenie] +synonym: "up regulation of response to propan-1-ol" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to propan-1-ol" EXACT [GOC:TermGenie] +synonym: "upregulation of response to propan-1-ol" EXACT [GOC:TermGenie] +is_a: GO:1901421 ! positive regulation of response to alcohol +is_a: GO:1901445 ! regulation of response to propan-1-ol +relationship: positively_regulates GO:1901427 ! response to propan-1-ol + +[Term] +id: GO:1901448 +name: regulation of response to butan-1-ol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1901419 ! regulation of response to alcohol +relationship: regulates GO:1901422 ! response to butan-1-ol + +[Term] +id: GO:1901449 +name: negative regulation of response to butan-1-ol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "downregulation of response to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "inhibition of response to butan-1-ol" NARROW [GOC:TermGenie] +is_a: GO:1901420 ! negative regulation of response to alcohol +is_a: GO:1901448 ! regulation of response to butan-1-ol +relationship: negatively_regulates GO:1901422 ! response to butan-1-ol + +[Term] +id: GO:1901450 +name: positive regulation of response to butan-1-ol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to butan-1-ol." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to butan-1-ol" NARROW [GOC:TermGenie] +synonym: "up regulation of response to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "upregulation of response to butan-1-ol" EXACT [GOC:TermGenie] +is_a: GO:1901421 ! positive regulation of response to alcohol +is_a: GO:1901448 ! regulation of response to butan-1-ol +relationship: positively_regulates GO:1901422 ! response to butan-1-ol + +[Term] +id: GO:1901451 +name: regulation of response to benzene +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:1901423 ! response to benzene + +[Term] +id: GO:1901452 +name: negative regulation of response to benzene +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to benzene" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to benzene" EXACT [GOC:TermGenie] +synonym: "downregulation of response to benzene" EXACT [GOC:TermGenie] +synonym: "inhibition of response to benzene" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901451 ! regulation of response to benzene +relationship: negatively_regulates GO:1901423 ! response to benzene + +[Term] +id: GO:1901453 +name: positive regulation of response to benzene +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to benzene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to benzene" NARROW [GOC:TermGenie] +synonym: "up regulation of response to benzene" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to benzene" EXACT [GOC:TermGenie] +synonym: "upregulation of response to benzene" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901451 ! regulation of response to benzene +relationship: positively_regulates GO:1901423 ! response to benzene + +[Term] +id: GO:1901454 +name: regulation of response to toluene +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:1901424 ! response to toluene + +[Term] +id: GO:1901455 +name: negative regulation of response to toluene +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to toluene" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to toluene" EXACT [GOC:TermGenie] +synonym: "downregulation of response to toluene" EXACT [GOC:TermGenie] +synonym: "inhibition of response to toluene" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901454 ! regulation of response to toluene +relationship: negatively_regulates GO:1901424 ! response to toluene + +[Term] +id: GO:1901456 +name: positive regulation of response to toluene +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to toluene." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to toluene" NARROW [GOC:TermGenie] +synonym: "up regulation of response to toluene" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to toluene" EXACT [GOC:TermGenie] +synonym: "upregulation of response to toluene" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901454 ! regulation of response to toluene +relationship: positively_regulates GO:1901424 ! response to toluene + +[Term] +id: GO:1901457 +name: regulation of response to acetate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0010034 ! response to acetate + +[Term] +id: GO:1901458 +name: negative regulation of response to acetate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to acetate" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to acetate" EXACT [GOC:TermGenie] +synonym: "downregulation of response to acetate" EXACT [GOC:TermGenie] +synonym: "inhibition of response to acetate" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901457 ! regulation of response to acetate +relationship: negatively_regulates GO:0010034 ! response to acetate + +[Term] +id: GO:1901459 +name: positive regulation of response to acetate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to acetate." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to acetate" NARROW [GOC:TermGenie] +synonym: "up regulation of response to acetate" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to acetate" EXACT [GOC:TermGenie] +synonym: "upregulation of response to acetate" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901457 ! regulation of response to acetate +relationship: positively_regulates GO:0010034 ! response to acetate + +[Term] +id: GO:1901460 +name: regulation of response to formic acid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:1901425 ! response to formic acid + +[Term] +id: GO:1901461 +name: negative regulation of response to formic acid +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of response to formic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to formic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of response to formic acid" EXACT [GOC:TermGenie] +synonym: "inhibition of response to formic acid" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1901460 ! regulation of response to formic acid +relationship: negatively_regulates GO:1901425 ! response to formic acid + +[Term] +id: GO:1901462 +name: positive regulation of response to formic acid +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to formic acid." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of response to formic acid" NARROW [GOC:TermGenie] +synonym: "up regulation of response to formic acid" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to formic acid" EXACT [GOC:TermGenie] +synonym: "upregulation of response to formic acid" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901460 ! regulation of response to formic acid +relationship: positively_regulates GO:1901425 ! response to formic acid + +[Term] +id: GO:1901463 +name: regulation of tetrapyrrole biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1901401 ! regulation of tetrapyrrole metabolic process +relationship: regulates GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:1901464 +name: negative regulation of tetrapyrrole biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "down regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "inhibition of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1901402 ! negative regulation of tetrapyrrole metabolic process +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +relationship: negatively_regulates GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:1901465 +name: positive regulation of tetrapyrrole biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "activation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tetrapyrrole synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1901403 ! positive regulation of tetrapyrrole metabolic process +is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process +relationship: positively_regulates GO:0033014 ! tetrapyrrole biosynthetic process + +[Term] +id: GO:1901466 +name: regulation of ferulate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ferulate degradation" EXACT [GOC:TermGenie] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:1901067 ! ferulate catabolic process + +[Term] +id: GO:1901467 +name: negative regulation of ferulate catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of ferulate catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferulate degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1901466 ! regulation of ferulate catabolic process +relationship: negatively_regulates GO:1901067 ! ferulate catabolic process + +[Term] +id: GO:1901468 +name: positive regulation of ferulate catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ferulate catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "activation of ferulate catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "activation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferulate degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of ferulate breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of ferulate catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ferulate catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ferulate degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1901466 ! regulation of ferulate catabolic process +relationship: positively_regulates GO:1901067 ! ferulate catabolic process + +[Term] +id: GO:1901469 +name: regulation of syringal lignin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process +relationship: regulates GO:1901065 ! syringal lignin catabolic process + +[Term] +id: GO:1901470 +name: negative regulation of syringal lignin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "down regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:1901469 ! regulation of syringal lignin catabolic process +relationship: negatively_regulates GO:1901065 ! syringal lignin catabolic process + +[Term] +id: GO:1901471 +name: positive regulation of syringal lignin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of syringal lignin catabolic process." [GOC:mengo_curators, GOC:TermGenie] +synonym: "activation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "activation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of syringal lignin degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of S-lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of syringal lignin degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1901469 ! regulation of syringal lignin catabolic process +relationship: positively_regulates GO:1901065 ! syringal lignin catabolic process + +[Term] +id: GO:1901472 +name: regulation of Golgi calcium ion export +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +relationship: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi + +[Term] +id: GO:1901474 +name: azole transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0045118 +def: "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] +synonym: "azole transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901475 +name: pyruvate transmembrane transport +namespace: biological_process +def: "The directed movement of pyruvate across a membrane." [GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "pyruvate membrane transport" EXACT [] +is_a: GO:0006848 ! pyruvate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1901477 +name: benomyl transmembrane transport +namespace: biological_process +def: "The directed movement of benomyl across a membrane." [GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "benomyl membrane transport" EXACT [] +is_a: GO:0015900 ! benomyl transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1901478 +name: aminotriazole transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015241 +def: "Enables the transfer of amitrole from one side of a membrane to the other." [GOC:TermGenie] +synonym: "aminotriazole transporter activity" BROAD [] +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:1901479 +name: benomyl transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015242 +def: "Enables the transfer of benomyl from one side of a membrane to the other." [GOC:TermGenie] +synonym: "benomyl transporter activity" RELATED [] +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0042910 ! xenobiotic transmembrane transporter activity + +[Term] +id: GO:1901480 +name: oleate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of oleate from one side of a membrane to the other." [GOC:TermGenie, PMID:19493158, RHEA:33655] +synonym: "oleate transporter activity" RELATED [] +xref: RHEA:33655 +is_a: GO:0005324 ! long-chain fatty acid transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015245 ! fatty acid transmembrane transporter activity + +[Term] +id: GO:1901481 +name: L-glutamate import involved in cellular response to nitrogen starvation +namespace: biological_process +def: "Any L-glutamate import that is involved in cellular response to nitrogen starvation." [GOC:TermGenie] +synonym: "L-glutamate uptake involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie] +is_a: GO:0051938 ! L-glutamate import +relationship: part_of GO:0006995 ! cellular response to nitrogen starvation + +[Term] +id: GO:1901482 +name: L-lysine import into vacuole involved in cellular response to nitrogen starvation +namespace: biological_process +def: "A L-lysine import into the vacuole that is involved in cellular response to nitrogen starvation." [GOC:TermGenie] +is_a: GO:0090517 ! L-lysine transmembrane import into vacuole +relationship: part_of GO:0006995 ! cellular response to nitrogen starvation + +[Term] +id: GO:1901483 +name: regulation of transcription factor catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559] +synonym: "regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of transcription factor degradation" EXACT [GOC:TermGenie] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +relationship: regulates GO:0036369 ! transcription factor catabolic process + +[Term] +id: GO:1901484 +name: negative regulation of transcription factor catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw] +synonym: "down regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription factor catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription factor degradation" EXACT [GOC:TermGenie] +is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1901483 ! regulation of transcription factor catabolic process +relationship: negatively_regulates GO:0036369 ! transcription factor catabolic process + +[Term] +id: GO:1901485 +name: positive regulation of transcription factor catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription factor catabolic process." [GOC:al, GOC:TermGenie, GOC:vw, PMID:22833559] +synonym: "activation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "activation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "activation of transcription factor catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "activation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription factor degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasome-mediated transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of sequence-specific DNA binding transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription factor breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription factor catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription factor degradation" EXACT [GOC:TermGenie] +is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1901483 ! regulation of transcription factor catabolic process +relationship: positively_regulates GO:0036369 ! transcription factor catabolic process + +[Term] +id: GO:1901486 +name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process +namespace: biological_process +def: "OBSOLETE. Positive regulation of transcription factor catabolism that results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation" NARROW [GOC:bf] +synonym: "negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolism" EXACT [GOC:bf] +synonym: "negative regulation of SREBP-mediated signaling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signalling pathway by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901487 +name: obsolete negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels +namespace: biological_process +def: "OBSOLETE. Positive regulation of transcription factor catabolism in response to increased oxygen levels, which results in negative regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] +comment: The reason for obsoletion is that this is better captured in a GO-CAM model. +synonym: "negative regulation of SREBP signaling by acceleration of SREBP degradation, in response to increased oxygen levels" NARROW [PMID:22833559] +synonym: "negative regulation of SREBP signaling by positive regulation of transcription factor catabolism in response to increased oxygen levels" EXACT [GOC:bf] +synonym: "negative regulation of SREBP signaling pathway by positive regulation of SREBP degradation, in response to elevated oxygen" NARROW [GOC:bf] +synonym: "negative regulation of SREBP-mediated signaling pathway in presence of oxygen by positive regulation of transcription factor catabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels by positive regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901488 +name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process +namespace: biological_process +def: "OBSOLETE. Negative regulation of transcription factor catabolism that results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +synonym: "positive regulation of SREBP signaling pathway by inhibition of SREBP degradation" NARROW [PMID:22833559] +synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation" NARROW [PMID:22833559] +synonym: "positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolism" EXACT [GOC:bf] +synonym: "positive regulation of SREBP-mediated signaling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of SREBP-mediated signalling pathway by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901489 +name: obsolete positive regulation of SREBP signaling pathway by negative regulation of transcription factor catabolic process in response to decreased oxygen levels +namespace: biological_process +def: "OBSOLETE. Negative regulation of transcription factor catabolism in response to decreased oxygen levels, which results in positive regulation of the SREBP signaling pathway." [GOC:TermGenie, GOC:vw, PMID:22833559] +comment: The reason for obsoletion is that this term should be represented by a GO-CAM model. +synonym: "positive regulation of SREBP signaling by inhibition of SREBP degradation in response to decreased oxygen levels" EXACT [GOC:bf] +synonym: "positive regulation of SREBP signaling by negative regulation of transcription factor catabolism at low oxygen levels" EXACT [GOC:bf] +synonym: "positive regulation of SREBP signaling pathway by negative regulation of SREBP degradation, in response to decreased oxygen" NARROW [PMID:22833559] +synonym: "positive regulation of SREBP-mediated signaling pathway in absence of oxygen by negative regulation of transcription factor catabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels by negative regulation of transcription factor catabolic process" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901490 +name: regulation of lymphangiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] +synonym: "regulation of lymph vessel formation" EXACT [GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0001946 ! lymphangiogenesis + +[Term] +id: GO:1901491 +name: negative regulation of lymphangiogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] +synonym: "down regulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "down regulation of lymphangiogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "downregulation of lymphangiogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of lymph vessel formation" NARROW [GOC:TermGenie] +synonym: "inhibition of lymphangiogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of lymph vessel formation" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901490 ! regulation of lymphangiogenesis +relationship: negatively_regulates GO:0001946 ! lymphangiogenesis + +[Term] +id: GO:1901492 +name: positive regulation of lymphangiogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphangiogenesis." [GOC:dph, GOC:TermGenie, PMID:20133819] +synonym: "activation of lymph vessel formation" NARROW [GOC:TermGenie] +synonym: "activation of lymphangiogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "up regulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "up regulation of lymphangiogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lymphangiogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of lymph vessel formation" EXACT [GOC:TermGenie] +synonym: "upregulation of lymphangiogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1901490 ! regulation of lymphangiogenesis +relationship: positively_regulates GO:0001946 ! lymphangiogenesis + +[Term] +id: GO:1901493 +name: response to decalin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decalin stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1901494 +name: regulation of cysteine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] +synonym: "regulation of cysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process +relationship: regulates GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:1901495 +name: negative regulation of cysteine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] +synonym: "down regulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of cysteine metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cysteine metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of cysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1901494 ! regulation of cysteine metabolic process +relationship: negatively_regulates GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:1901496 +name: positive regulation of cysteine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cysteine metabolic process." [GOC:TermGenie] +synonym: "activation of cysteine metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of cysteine metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cysteine metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of cysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:1901494 ! regulation of cysteine metabolic process +relationship: positively_regulates GO:0006534 ! cysteine metabolic process + +[Term] +id: GO:1901497 +name: response to diphenyl ether +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenyl ether stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether + +[Term] +id: GO:1901498 +name: response to tetralin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetralin stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1901499 +name: response to hexane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexane stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1901500 +name: response to p-xylene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a p-xylene stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:1901501 ! response to xylene + +[Term] +id: GO:1901501 +name: response to xylene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xylene stimulus." [GOC:mengo_curators, GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1901502 +name: ether catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ether." [GOC:pr, GOC:TermGenie] +synonym: "ether breakdown" EXACT [GOC:TermGenie] +synonym: "ether catabolism" EXACT [GOC:TermGenie] +synonym: "ether degradation" EXACT [GOC:TermGenie] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901503 +name: ether biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ether." [GOC:pr, GOC:TermGenie] +synonym: "ether anabolism" EXACT [GOC:TermGenie] +synonym: "ether biosynthesis" EXACT [GOC:TermGenie] +synonym: "ether formation" EXACT [GOC:TermGenie] +synonym: "ether synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901504 +name: triazole transport +namespace: biological_process +def: "The directed movement of a triazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] +is_a: GO:0071702 ! organic substance transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:1901505 +name: carbohydrate derivative transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carbohydrate derivative from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "carbohydrate derivative transporter activity" RELATED [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901506 +name: regulation of acylglycerol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] +synonym: "regulation of glyceride transport" EXACT [GOC:TermGenie] +is_a: GO:0032368 ! regulation of lipid transport +relationship: regulates GO:0034196 ! acylglycerol transport + +[Term] +id: GO:1901507 +name: negative regulation of acylglycerol transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] +synonym: "down regulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "down regulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "downregulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "downregulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "inhibition of acylglycerol transport" NARROW [GOC:TermGenie] +synonym: "inhibition of glyceride transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of glyceride transport" EXACT [GOC:TermGenie] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:1901506 ! regulation of acylglycerol transport +relationship: negatively_regulates GO:0034196 ! acylglycerol transport + +[Term] +id: GO:1901508 +name: positive regulation of acylglycerol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acylglycerol transport." [GOC:sart, GOC:TermGenie] +synonym: "activation of acylglycerol transport" NARROW [GOC:TermGenie] +synonym: "activation of glyceride transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "up regulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "up regulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of glyceride transport" EXACT [GOC:TermGenie] +synonym: "upregulation of acylglycerol transport" EXACT [GOC:TermGenie] +synonym: "upregulation of glyceride transport" EXACT [GOC:TermGenie] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:1901506 ! regulation of acylglycerol transport +relationship: positively_regulates GO:0034196 ! acylglycerol transport + +[Term] +id: GO:1901509 +name: regulation of endothelial tube morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." [GOC:dph, GOC:TermGenie] +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0061154 ! endothelial tube morphogenesis + +[Term] +id: GO:1901510 +name: (-)-microperfuranone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-microperfuranone." [GOC:di, GOC:TermGenie] +synonym: "(-)-microperfuranone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018904 ! ether metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:1901511 +name: (-)-microperfuranone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone." [GOC:di, GOC:TermGenie] +synonym: "(-)-microperfuranone breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-microperfuranone catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-microperfuranone degradation" EXACT [GOC:TermGenie] +is_a: GO:1901335 ! lactone catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901510 ! (-)-microperfuranone metabolic process + +[Term] +id: GO:1901512 +name: (-)-microperfuranone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-microperfuranone." [GOC:di, GOC:TermGenie] +synonym: "(-)-microperfuranone anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-microperfuranone biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-microperfuranone formation" EXACT [GOC:TermGenie] +synonym: "(-)-microperfuranone synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901336 ! lactone biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901510 ! (-)-microperfuranone metabolic process + +[Term] +id: GO:1901513 +name: lipo-chitin oligosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901514 +name: ATPase-coupled lipo-chitin oligosaccharide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipo-chitin oligosaccharide(in) = ADP + phosphate + lipo-chitin oligosaccharide(out)." [GOC:TermGenie] +synonym: "lipo-chitin oligosaccharide transmembrane-transporting ATPase activity" RELATED [] +is_a: GO:0042626 ! ATPase-coupled transmembrane transporter activity +is_a: GO:1901513 ! lipo-chitin oligosaccharide transmembrane transporter activity + +[Term] +id: GO:1901515 +name: poly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of poly-beta-1,6-N-acetyl-D-glucosamine from one side of a membrane to the other." [GOC:TermGenie, PMID:15090514, PMID:18359807] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901516 +name: aspyridone A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aspyridone A." [GOC:di, GOC:TermGenie] +synonym: "aspyridone A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:1901517 +name: aspyridone A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aspyridone A." [GOC:di, GOC:TermGenie] +synonym: "aspyridone A breakdown" EXACT [GOC:TermGenie] +synonym: "aspyridone A catabolism" EXACT [GOC:TermGenie] +synonym: "aspyridone A degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process +is_a: GO:1901516 ! aspyridone A metabolic process + +[Term] +id: GO:1901518 +name: aspyridone A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aspyridone A." [GOC:di, GOC:TermGenie] +synonym: "aspyridone A anabolism" EXACT [GOC:TermGenie] +synonym: "aspyridone A biosynthesis" EXACT [GOC:TermGenie] +synonym: "aspyridone A formation" EXACT [GOC:TermGenie] +synonym: "aspyridone A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process +is_a: GO:1901516 ! aspyridone A metabolic process + +[Term] +id: GO:1901519 +name: aspyridone B metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aspyridone B." [GOC:di, GOC:TermGenie] +synonym: "aspyridone B metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:1901520 +name: aspyridone B catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of aspyridone B." [GOC:di, GOC:TermGenie] +synonym: "aspyridone B breakdown" EXACT [GOC:TermGenie] +synonym: "aspyridone B catabolism" EXACT [GOC:TermGenie] +synonym: "aspyridone B degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process +is_a: GO:1901519 ! aspyridone B metabolic process + +[Term] +id: GO:1901521 +name: aspyridone B biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aspyridone B." [GOC:di, GOC:TermGenie] +synonym: "aspyridone B anabolism" EXACT [GOC:TermGenie] +synonym: "aspyridone B biosynthesis" EXACT [GOC:TermGenie] +synonym: "aspyridone B formation" EXACT [GOC:TermGenie] +synonym: "aspyridone B synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process +is_a: GO:1901519 ! aspyridone B metabolic process + +[Term] +id: GO:1901522 +name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777] +synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0070887 ! cellular response to chemical stimulus + +[Term] +id: GO:1901523 +name: icosanoid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of icosanoid." [GOC:pr, GOC:TermGenie] +synonym: "icosanoid breakdown" EXACT [GOC:TermGenie] +synonym: "icosanoid catabolism" EXACT [GOC:TermGenie] +synonym: "icosanoid degradation" EXACT [GOC:TermGenie] +is_a: GO:1901569 ! fatty acid derivative catabolic process + +[Term] +id: GO:1901524 +name: regulation of mitophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macromitophagy." [GOC:TermGenie] +synonym: "regulation of macromitophagy" EXACT [] +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:1903146 ! regulation of autophagy of mitochondrion +relationship: regulates GO:0000423 ! mitophagy + +[Term] +id: GO:1901525 +name: negative regulation of mitophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy." [GOC:TermGenie] +synonym: "down regulation of macromitophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of macromitophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of macromitophagy" EXACT [GOC:TermGenie] +synonym: "inhibition of macromitophagy" NARROW [GOC:TermGenie] +synonym: "negative regulation of macromitophagy" EXACT [] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:1901524 ! regulation of mitophagy +is_a: GO:1903147 ! negative regulation of autophagy of mitochondrion +relationship: negatively_regulates GO:0000423 ! mitophagy + +[Term] +id: GO:1901526 +name: positive regulation of mitophagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitophagy." [GOC:TermGenie] +synonym: "activation of macromitophagy" NARROW [GOC:TermGenie] +synonym: "positive regulation of macromitophagy" EXACT [] +synonym: "up regulation of macromitophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of macromitophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of macromitophagy" EXACT [GOC:TermGenie] +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:1901524 ! regulation of mitophagy +is_a: GO:1903599 ! positive regulation of autophagy of mitochondrion +relationship: positively_regulates GO:0000423 ! mitophagy + +[Term] +id: GO:1901527 +name: abscisic acid-activated signaling pathway involved in stomatal movement +namespace: biological_process +def: "Any abscisic acid mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie, PMID:22730405] +synonym: "abscisic acid mediated signaling pathway involved in stomatal movement" RELATED [] +synonym: "abscisic acid mediated signalling involved in stomatal movement" EXACT [GOC:TermGenie] +is_a: GO:0009738 ! abscisic acid-activated signaling pathway +relationship: part_of GO:0010118 ! stomatal movement + +[Term] +id: GO:1901528 +name: hydrogen peroxide mediated signaling pathway involved in stomatal movement +namespace: biological_process +def: "Any hydrogen peroxide mediated signaling pathway that is involved in stomatal movement." [GOC:TermGenie] +synonym: "H2O2 mediated signaling pathway involved in stomatal movement" EXACT [GOC:TermGenie] +synonym: "hydrogen peroxide mediated signalling pathway involved in stomatal movement" EXACT [GOC:TermGenie] +is_a: GO:0071588 ! hydrogen peroxide mediated signaling pathway +relationship: part_of GO:0010118 ! stomatal movement + +[Term] +id: GO:1901529 +name: positive regulation of anion channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anion channel activity." [GOC:TermGenie] +synonym: "activation of anion channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of anion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of anion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of anion channel activity" EXACT [GOC:TermGenie] +is_a: GO:0010359 ! regulation of anion channel activity +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1903961 ! positive regulation of anion transmembrane transport + +[Term] +id: GO:1901530 +name: response to hypochlorite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hypochlorite stimulus." [GOC:pr, GOC:TermGenie, PMID:22223481] +is_a: GO:0000302 ! response to reactive oxygen species +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:1901531 +name: hypochlorite binding +namespace: molecular_function +def: "Binding to hypochlorite." [GOC:pr, GOC:TermGenie, PMID:22223481] +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:1901532 +name: regulation of hematopoietic progenitor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] +synonym: "regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of hemopoietic progenitor cell differentiation" EXACT [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0002244 ! hematopoietic progenitor cell differentiation + +[Term] +id: GO:1901533 +name: negative regulation of hematopoietic progenitor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] +synonym: "down regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "down regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "down-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "downregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "inhibition of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemopoietic progenitor cell differentiation" EXACT [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation +relationship: negatively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation + +[Term] +id: GO:1901534 +name: positive regulation of hematopoietic progenitor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation." [GOC:BHF, GOC:rl, GOC:TermGenie] +synonym: "activation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "activation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "activation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "activation of hemopoietic progenitor cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemopoietic progenitor cell differentiation" EXACT [] +synonym: "up regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "up regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of haematopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of haemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of hematopoietic progenitor cell differentiation" RELATED [GOC:TermGenie] +synonym: "upregulation of hemopoietic progenitor cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation +relationship: positively_regulates GO:0002244 ! hematopoietic progenitor cell differentiation + +[Term] +id: GO:1901535 +name: regulation of DNA demethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0080111 ! DNA demethylation + +[Term] +id: GO:1901536 +name: negative regulation of DNA demethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] +synonym: "down regulation of DNA demethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA demethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA demethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA demethylation" NARROW [GOC:TermGenie] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:1901535 ! regulation of DNA demethylation +relationship: negatively_regulates GO:0080111 ! DNA demethylation + +[Term] +id: GO:1901537 +name: positive regulation of DNA demethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA demethylation." [GOC:TermGenie] +synonym: "activation of DNA demethylation" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA demethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA demethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA demethylation" EXACT [GOC:TermGenie] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:1901535 ! regulation of DNA demethylation +relationship: positively_regulates GO:0080111 ! DNA demethylation + +[Term] +id: GO:1901538 +name: changes to DNA methylation involved in embryo development +namespace: biological_process +def: "The addition or removal of methyl groups to DNA that contributes to the epigenetic regulation of embryonic gene expression." [GOC:TermGenie] +synonym: "changes in DNA methylation involved in embryo development" EXACT [GOC:TermGenie] +synonym: "changes in DNA methylation involved in embryogenesis" EXACT [GOC:TermGenie] +synonym: "changes in DNA methylation involved in embryonal development" RELATED [GOC:TermGenie] +synonym: "DNA methylation or demethylation involved in embryogenesis" EXACT [GOC:TermGenie] +synonym: "DNA methylation or demethylation involved in embryonal development" EXACT [GOC:TermGenie] +is_a: GO:0044728 ! DNA methylation or demethylation +relationship: part_of GO:0009790 ! embryo development + +[Term] +id: GO:1901539 +name: ent-pimara-8(14),15-diene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:1901540 +name: ent-pimara-8(14),15-diene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene breakdown" EXACT [GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene catabolism" EXACT [GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene degradation" EXACT [GOC:TermGenie] +is_a: GO:0046247 ! terpene catabolic process +is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process + +[Term] +id: GO:1901541 +name: ent-pimara-8(14),15-diene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ent-pimara-8(14),15-diene." [GOC:di, GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:1901539 ! ent-pimara-8(14),15-diene metabolic process + +[Term] +id: GO:1901542 +name: regulation of ent-pimara-8(14),15-diene biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +relationship: regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process + +[Term] +id: GO:1901543 +name: negative regulation of ent-pimara-8(14),15-diene biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "down regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process +relationship: negatively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process + +[Term] +id: GO:1901544 +name: positive regulation of ent-pimara-8(14),15-diene biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." [GOC:di, GOC:TermGenie] +synonym: "activation of ent-pimara-8(14),15-diene anabolism" NARROW [GOC:TermGenie] +synonym: "activation of ent-pimara-8(14),15-diene biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of ent-pimara-8(14),15-diene biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ent-pimara-8(14),15-diene formation" NARROW [GOC:TermGenie] +synonym: "activation of ent-pimara-8(14),15-diene synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ent-pimara-8(14),15-diene anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ent-pimara-8(14),15-diene biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ent-pimara-8(14),15-diene biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ent-pimara-8(14),15-diene formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ent-pimara-8(14),15-diene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1901542 ! regulation of ent-pimara-8(14),15-diene biosynthetic process +relationship: positively_regulates GO:1901541 ! ent-pimara-8(14),15-diene biosynthetic process + +[Term] +id: GO:1901545 +name: response to raffinose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus." [GOC:TermGenie] +is_a: GO:0009743 ! response to carbohydrate + +[Term] +id: GO:1901546 +name: regulation of synaptic vesicle lumen acidification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] +subset: goslim_synapse +synonym: "regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "regulation of synaptic vesicle lumen proton loading" EXACT syngo_official_label [] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0097401 ! synaptic vesicle lumen acidification + +[Term] +id: GO:1901547 +name: negative regulation of synaptic vesicle lumen acidification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie] +synonym: "negative regulation of proton loading" EXACT syngo_official_label [] +synonym: "negative regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0097401 ! synaptic vesicle lumen acidification + +[Term] +id: GO:1901548 +name: positive regulation of synaptic vesicle lumen acidification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle lumen acidification." [GOC:TermGenie] +synonym: "activation of synaptic vesicle lumen acidification" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle lumen pH reduction" NARROW [GOC:TermGenie] +synonym: "positive regulation of proton loading" EXACT syngo_official_label [] +synonym: "positive regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle lumen acidification" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle lumen pH reduction" EXACT [GOC:TermGenie] +is_a: GO:1901546 ! regulation of synaptic vesicle lumen acidification +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0097401 ! synaptic vesicle lumen acidification + +[Term] +id: GO:1901550 +name: regulation of endothelial cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] +is_a: GO:0045601 ! regulation of endothelial cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0001885 ! endothelial cell development + +[Term] +id: GO:1901551 +name: negative regulation of endothelial cell development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] +synonym: "down regulation of endothelial cell development" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelial cell development" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelial cell development" EXACT [GOC:TermGenie] +synonym: "inhibition of endothelial cell development" NARROW [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0045602 ! negative regulation of endothelial cell differentiation +is_a: GO:1901550 ! regulation of endothelial cell development +relationship: negatively_regulates GO:0001885 ! endothelial cell development + +[Term] +id: GO:1901552 +name: positive regulation of endothelial cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell development." [GOC:pr, GOC:TermGenie, PMID:19470579] +synonym: "activation of endothelial cell development" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelial cell development" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelial cell development" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelial cell development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:1901550 ! regulation of endothelial cell development +relationship: positively_regulates GO:0001885 ! endothelial cell development + +[Term] +id: GO:1901553 +name: malonic acid transmembrane transport +namespace: biological_process +def: "The directed movement of malonic acid across a membrane." [GOC:al, GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "malonic acid membrane transport" EXACT [] +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1900752 ! malonic acid transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1901554 +name: response to paracetamol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paracetamol stimulus." [GOC:TermGenie] +synonym: "response to acetaminophen" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901555 +name: response to paclitaxel +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GOC:TermGenie] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1901556 +name: response to candesartan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a candesartan stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901557 +name: response to fenofibrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fenofibrate stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1901558 +name: response to metformin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metformin stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1901559 +name: response to ribavirin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ribavirin stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901560 +name: response to purvalanol A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:TermGenie] +is_a: GO:0014074 ! response to purine-containing compound + +[Term] +id: GO:1901561 +name: response to benomyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901562 +name: response to paraquat +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus." [GOC:TermGenie] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1901563 +name: response to camptothecin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] +synonym: "response to CPT" EXACT [GOC:mah] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043279 ! response to alkaloid +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:1901564 +name: organonitrogen compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] +synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901565 +name: organonitrogen compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie] +synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901566 +name: organonitrogen compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] +synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] +synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901567 +name: fatty acid derivative binding +namespace: molecular_function +def: "Binding to fatty acid derivative." [GOC:pr, GOC:TermGenie] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1901568 +name: fatty acid derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acid derivative." [GOC:pr, GOC:TermGenie] +synonym: "fatty acid derivative metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901569 +name: fatty acid derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty acid derivative." [GOC:pr, GOC:TermGenie] +synonym: "fatty acid derivative breakdown" EXACT [GOC:TermGenie] +synonym: "fatty acid derivative catabolism" EXACT [GOC:TermGenie] +synonym: "fatty acid derivative degradation" EXACT [GOC:TermGenie] +is_a: GO:1901568 ! fatty acid derivative metabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1901570 +name: fatty acid derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acid derivative." [GOC:pr, GOC:TermGenie] +synonym: "fatty acid derivative anabolism" EXACT [GOC:TermGenie] +synonym: "fatty acid derivative biosynthesis" EXACT [GOC:TermGenie] +synonym: "fatty acid derivative formation" EXACT [GOC:TermGenie] +synonym: "fatty acid derivative synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901568 ! fatty acid derivative metabolic process +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901571 +name: fatty acid derivative transport +namespace: biological_process +def: "The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:1901572 +name: obsolete chemical substance metabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways involving chemical substance." [GOC:pr, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "chemical substance metabolic process" EXACT [] +synonym: "chemical substance metabolism" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901573 +name: obsolete chemical substance catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of chemical substance." [GOC:pr, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "chemical substance breakdown" EXACT [GOC:TermGenie] +synonym: "chemical substance catabolic process" EXACT [] +synonym: "chemical substance catabolism" EXACT [GOC:TermGenie] +synonym: "chemical substance degradation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901574 +name: obsolete chemical substance biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of chemical substance." [GOC:pr, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "chemical substance anabolism" EXACT [GOC:TermGenie] +synonym: "chemical substance biosynthesis" EXACT [GOC:TermGenie] +synonym: "chemical substance biosynthetic process" EXACT [] +synonym: "chemical substance formation" EXACT [GOC:TermGenie] +synonym: "chemical substance synthesis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901575 +name: organic substance catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] +synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie] +synonym: "organic molecular entity catabolic process" EXACT [] +synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie] +synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie] +synonym: "organic substance breakdown" EXACT [] +synonym: "organic substance catabolism" EXACT [] +synonym: "organic substance degradation" EXACT [] +is_a: GO:0009056 ! catabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901576 +name: organic substance biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] +synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] +synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] +synonym: "organic molecular entity biosynthetic process" EXACT [] +synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] +synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] +synonym: "organic substance anabolism" EXACT [] +synonym: "organic substance biosynthesis" EXACT [] +synonym: "organic substance formation" EXACT [] +synonym: "organic substance synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901577 +name: regulation of alkane biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] +synonym: "regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "regulation of alkane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0043447 ! alkane biosynthetic process + +[Term] +id: GO:1901578 +name: negative regulation of alkane biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "down regulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "downregulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of alkane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of alkane formation" EXACT [GOC:TermGenie] +synonym: "inhibition of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of alkane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: negatively_regulates GO:0043447 ! alkane biosynthetic process + +[Term] +id: GO:1901579 +name: positive regulation of alkane biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alkane biosynthetic process." [GOC:TermGenie] +synonym: "activation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "activation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of alkane biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of alkane formation" EXACT [GOC:TermGenie] +synonym: "activation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "up regulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of alkane synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of alkane anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of alkane biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of alkane biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of alkane formation" EXACT [GOC:TermGenie] +synonym: "upregulation of alkane synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1901577 ! regulation of alkane biosynthetic process +relationship: positively_regulates GO:0043447 ! alkane biosynthetic process + +[Term] +id: GO:1901580 +name: regulation of telomeric RNA transcription from RNA pol II promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] +synonym: "regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II + +[Term] +id: GO:1901581 +name: negative regulation of telomeric RNA transcription from RNA pol II promoter +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] +synonym: "down regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter +relationship: negatively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II + +[Term] +id: GO:1901582 +name: positive regulation of telomeric RNA transcription from RNA pol II promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomeric RNA transcription from RNA pol II promoter." [GOC:TermGenie] +synonym: "activation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "activation of telomeric RNA transcription from RNA pol II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric RNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric RNA transcription from RNA pol II promoter" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:1901580 ! regulation of telomeric RNA transcription from RNA pol II promoter +relationship: positively_regulates GO:0097394 ! telomeric repeat-containing RNA transcription by RNA polymerase II + +[Term] +id: GO:1901583 +name: tetrapeptide import across plasma membrane +namespace: biological_process +def: "The directed movement of a tetrapeptide from outside of a cell, across the plasma membrane and into the cytosol." [GOC:TermGenie, PMID:22226946] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "tetrapeptide membrane transport" EXACT [] +synonym: "tetrapeptide transmembrane transport" BROAD [] +is_a: GO:0140205 ! oligopeptide import across plasma membrane + +[Term] +id: GO:1901584 +name: tetrapeptide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of tetrapeptide from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0035673 ! oligopeptide transmembrane transporter activity + +[Term] +id: GO:1901585 +name: regulation of acid-sensing ion channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] +synonym: "regulation of ASIC activity" EXACT [GOC:TermGenie] +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1901586 +name: negative regulation of acid-sensing ion channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] +synonym: "down regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "inhibition of acid-sensing ion channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ASIC activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ASIC activity" EXACT [GOC:TermGenie] +is_a: GO:1901585 ! regulation of acid-sensing ion channel activity +is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1901587 +name: positive regulation of acid-sensing ion channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acid-sensing ion channel activity." [GOC:TermGenie] +synonym: "activation of acid-sensing ion channel activity" NARROW [GOC:TermGenie] +synonym: "activation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ASIC activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acid-sensing ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ASIC activity" EXACT [GOC:TermGenie] +is_a: GO:1901585 ! regulation of acid-sensing ion channel activity +is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1901588 +name: dendritic microtubule +namespace: cellular_component +def: "Any microtubule in a dendrite, a neuron projection." [GOC:TermGenie, NIF_Subcellular:sao110773650] +synonym: "microtubule of dendrite" EXACT [GOC:TermGenie] +synonym: "microtubulus of dendrite" EXACT [GOC:TermGenie] +xref: NIF_Subcellular:sao110773650 +is_a: GO:0005874 ! microtubule +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:1901589 +name: axon microtubule bundle +namespace: cellular_component +def: "An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment." [GOC:TermGenie, NIF_Subcellular:sao707332678] +synonym: "axon microtubule fascicle" EXACT [] +synonym: "microtubule bundle of axon" EXACT [GOC:TermGenie] +synonym: "microtubule fascicle of axon" EXACT [GOC:TermGenie] +xref: NIF_Subcellular:sao707332678 +is_a: GO:0097427 ! microtubule bundle +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:1901591 +name: regulation of double-strand break repair via break-induced replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie] +is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination +relationship: regulates GO:0000727 ! double-strand break repair via break-induced replication + +[Term] +id: GO:1901592 +name: negative regulation of double-strand break repair via break-induced replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via break-induced replication." [GOC:TermGenie] +synonym: "down regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] +synonym: "downregulation of double-strand break repair via break-induced replication" EXACT [GOC:TermGenie] +synonym: "inhibition of double-strand break repair via break-induced replication" NARROW [GOC:TermGenie] +is_a: GO:1901591 ! regulation of double-strand break repair via break-induced replication +is_a: GO:2000042 ! negative regulation of double-strand break repair via homologous recombination +relationship: negatively_regulates GO:0000727 ! double-strand break repair via break-induced replication + +[Term] +id: GO:1901593 +name: response to GW 7647 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus." [GOC:TermGenie] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901594 +name: response to capsazepine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901595 +name: response to hesperadin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0014075 ! response to amine +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901596 +name: response to reversine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus." [GOC:TermGenie] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901597 +name: response to carbendazim +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus." [GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901598 +name: (-)-pinoresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-pinoresinol." [GOC:TermGenie] +synonym: "(-)-pinoresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1901599 +name: (-)-pinoresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-pinoresinol." [GOC:TermGenie] +synonym: "(-)-pinoresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-pinoresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-pinoresinol formation" EXACT [GOC:TermGenie] +synonym: "(-)-pinoresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901598 ! (-)-pinoresinol metabolic process + +[Term] +id: GO:1901600 +name: strigolactone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving strigolactone." [GOC:TermGenie] +synonym: "strigolactone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:1901601 +name: strigolactone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of strigolactone." [GOC:TermGenie] +synonym: "strigolactone anabolism" EXACT [GOC:TermGenie] +synonym: "strigolactone biosynthesis" EXACT [GOC:TermGenie] +synonym: "strigolactone formation" EXACT [GOC:TermGenie] +synonym: "strigolactone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process +is_a: GO:1901600 ! strigolactone metabolic process + +[Term] +id: GO:1901602 +name: dethiobiotin binding +namespace: molecular_function +def: "Binding to dethiobiotin." [GOC:TermGenie] +is_a: GO:0033218 ! amide binding +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1901604 +name: dethiobiotin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of dethiobiotin from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:1901605 +name: alpha-amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] +synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006520 ! cellular amino acid metabolic process + +[Term] +id: GO:1901606 +name: alpha-amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] +synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1901607 +name: alpha-amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] +synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] +synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008652 ! cellular amino acid biosynthetic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1901608 +name: regulation of vesicle transport along microtubule +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] +synonym: "regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +is_a: GO:1902513 ! regulation of organelle transport along microtubule +relationship: regulates GO:0047496 ! vesicle transport along microtubule + +[Term] +id: GO:1901609 +name: negative regulation of vesicle transport along microtubule +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] +synonym: "down regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "down regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "downregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +synonym: "inhibition of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "inhibition of vesicle transport along microtubule" NARROW [GOC:TermGenie] +synonym: "negative regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +relationship: negatively_regulates GO:0047496 ! vesicle transport along microtubule + +[Term] +id: GO:1901610 +name: positive regulation of vesicle transport along microtubule +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule." [GOC:TermGenie] +synonym: "activation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "activation of vesicle transport along microtubule" NARROW [GOC:TermGenie] +synonym: "positive regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "up regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule-based vesicle localization" EXACT [GOC:TermGenie] +synonym: "upregulation of vesicle transport along microtubule" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +relationship: positively_regulates GO:0047496 ! vesicle transport along microtubule + +[Term] +id: GO:1901611 +name: phosphatidylglycerol binding +namespace: molecular_function +def: "Binding to phosphatidylglycerol." [GOC:kmv, GOC:TermGenie] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:1901612 +name: cardiolipin binding +namespace: molecular_function +def: "Binding to cardiolipin." [GOC:kmv, GOC:TermGenie] +is_a: GO:1901611 ! phosphatidylglycerol binding + +[Term] +id: GO:1901613 +name: negative regulation of terminal button organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] +synonym: "down regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "down regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal button organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal button organization" EXACT [GOC:TermGenie] +synonym: "downregulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal button organization" EXACT [GOC:TermGenie] +synonym: "inhibition of bouton organization" NARROW [GOC:TermGenie] +synonym: "inhibition of presynaptic bouton organization" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic bouton organization" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal bouton organization" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal button organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal button organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of terminal button organisation" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:2000331 ! regulation of terminal button organization +relationship: negatively_regulates GO:0072553 ! terminal button organization + +[Term] +id: GO:1901614 +name: positive regulation of terminal button organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of terminal button organization." [GOC:TermGenie, PMID:22426000] +synonym: "activation of bouton organization" NARROW [GOC:TermGenie] +synonym: "activation of presynaptic bouton organization" NARROW [GOC:TermGenie] +synonym: "activation of synaptic bouton organization" NARROW [GOC:TermGenie] +synonym: "activation of terminal bouton organization" NARROW [GOC:TermGenie] +synonym: "activation of terminal button organisation" NARROW [GOC:TermGenie] +synonym: "activation of terminal button organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal button organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal button organization" EXACT [GOC:TermGenie] +synonym: "upregulation of bouton organization" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic bouton organization" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal bouton organization" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal button organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal button organization" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:2000331 ! regulation of terminal button organization +relationship: positively_regulates GO:0072553 ! terminal button organization + +[Term] +id: GO:1901615 +name: organic hydroxy compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] +synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1901616 +name: organic hydroxy compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of organic hydroxy compound." [GOC:pr, GOC:TermGenie] +synonym: "organic hydroxy compound breakdown" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound catabolism" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901575 ! organic substance catabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1901617 +name: organic hydroxy compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie] +synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie] +synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901576 ! organic substance biosynthetic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1901618 +name: organic hydroxy compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of organic hydroxy compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901619 +name: obsolete tRNA methylation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule as a result of deprivation of nitrogen." [GOC:TermGenie, PMID:23074192] +is_obsolete: true + +[Term] +id: GO:1901620 +name: regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] +synonym: "regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +is_a: GO:0008589 ! regulation of smoothened signaling pathway +relationship: regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning + +[Term] +id: GO:1901621 +name: negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] +synonym: "down regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "down-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "downregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "downregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "downregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "downregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "inhibition of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "inhibition of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "inhibition of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "inhibition of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "negative regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "negative regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "negative regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +is_a: GO:0045879 ! negative regulation of smoothened signaling pathway +is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +relationship: negatively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning + +[Term] +id: GO:1901622 +name: positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smoothened signaling pathway involved in dorsal/ventral neural tube patterning." [GOC:TermGenie] +synonym: "activation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "activation of hh signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "activation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "activation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" NARROW [GOC:TermGenie] +synonym: "positive regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "positive regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "positive regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up-regulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up-regulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up-regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "up-regulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "upregulation of hedgehog signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "upregulation of hh signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "upregulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +synonym: "upregulation of smoothened signalling pathway involved in dorsal/ventral neural tube patterning" EXACT [GOC:TermGenie] +is_a: GO:0045880 ! positive regulation of smoothened signaling pathway +is_a: GO:1901620 ! regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +relationship: positively_regulates GO:0060831 ! smoothened signaling pathway involved in dorsal/ventral neural tube patterning + +[Term] +id: GO:1901623 +name: regulation of lymphocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:2000401 ! regulation of lymphocyte migration +relationship: regulates GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:1901624 +name: negative regulation of lymphocyte chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis." [GOC:TermGenie] +synonym: "down regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] +synonym: "down-regulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] +synonym: "downregulation of lymphocyte chemotaxis" EXACT [GOC:TermGenie] +synonym: "inhibition of lymphocyte chemotaxis" NARROW [GOC:TermGenie] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:1901623 ! regulation of lymphocyte chemotaxis +is_a: GO:2000402 ! negative regulation of lymphocyte migration +relationship: negatively_regulates GO:0048247 ! lymphocyte chemotaxis + +[Term] +id: GO:1901625 +name: cellular response to ergosterol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ergosterol stimulus." [GOC:TermGenie] +is_a: GO:0036315 ! cellular response to sterol +is_a: GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:1901626 +name: regulation of postsynaptic membrane organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "regulation of post-synaptic membrane organization" EXACT [] +synonym: "regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:1901627 +name: negative regulation of postsynaptic membrane organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "down regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "downregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "inhibition of postsynaptic membrane organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of postsynaptic membrane organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of post-synaptic membrane organization" EXACT [] +synonym: "negative regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +is_a: GO:1901626 ! regulation of postsynaptic membrane organization +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:1901628 +name: positive regulation of postsynaptic membrane organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of postsynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "activation of postsynaptic membrane organisation" NARROW [GOC:TermGenie] +synonym: "activation of postsynaptic membrane organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of post-synaptic membrane organization" EXACT [] +synonym: "positive regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "upregulation of postsynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of postsynaptic membrane organization" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1901626 ! regulation of postsynaptic membrane organization +relationship: positively_regulates GO:0001941 ! postsynaptic membrane organization + +[Term] +id: GO:1901629 +name: regulation of presynaptic membrane organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "regulation of pre-synaptic membrane organization" EXACT [] +synonym: "regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0097090 ! presynaptic membrane organization + +[Term] +id: GO:1901630 +name: negative regulation of presynaptic membrane organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "down regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "inhibition of presynaptic membrane organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of presynaptic membrane organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of pre-synaptic membrane organization" EXACT [] +synonym: "negative regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +is_a: GO:1901629 ! regulation of presynaptic membrane organization +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0097090 ! presynaptic membrane organization + +[Term] +id: GO:1901631 +name: positive regulation of presynaptic membrane organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of presynaptic membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "activation of presynaptic membrane organisation" NARROW [GOC:TermGenie] +synonym: "activation of presynaptic membrane organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of pre-synaptic membrane organization" EXACT [] +synonym: "positive regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic membrane organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic membrane organization" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1901629 ! regulation of presynaptic membrane organization +relationship: positively_regulates GO:0097090 ! presynaptic membrane organization + +[Term] +id: GO:1901632 +name: regulation of synaptic vesicle membrane organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0048499 ! synaptic vesicle membrane organization + +[Term] +id: GO:1901633 +name: negative regulation of synaptic vesicle membrane organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "down regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle membrane organization" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle membrane organization and biogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization +relationship: negatively_regulates GO:0048499 ! synaptic vesicle membrane organization + +[Term] +id: GO:1901634 +name: positive regulation of synaptic vesicle membrane organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle membrane organization." [GOC:TermGenie, PMID:22426000] +synonym: "activation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle membrane organisation" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle membrane organization" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of SLMV biogenesis" NARROW [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle membrane organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle membrane organization" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle membrane organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1901632 ! regulation of synaptic vesicle membrane organization +relationship: positively_regulates GO:0048499 ! synaptic vesicle membrane organization + +[Term] +id: GO:1901635 +name: obsolete regulation of maintenance of presynaptic active zone structure +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of maintenance of presynaptic active zone structure" EXACT [] +is_obsolete: true + +[Term] +id: GO:1901636 +name: obsolete negative regulation of maintenance of presynaptic active zone structure +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +synonym: "inhibition of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of maintenance of presynaptic active zone structure" EXACT [] +is_obsolete: true + +[Term] +id: GO:1901637 +name: obsolete positive regulation of maintenance of presynaptic active zone structure +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of presynaptic active zone structure." [GOC:TermGenie, PMID:22426000] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of maintenance of presynaptic active zone structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of maintenance of presynaptic active zone structure" EXACT [] +synonym: "up regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of presynaptic active zone structure" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901638 +name: obsolete copper ion import into ascospore-type prospore +namespace: biological_process +def: "OBSOLETE. Any copper ion import that takes place in ascospore-type prospore." [GOC:TermGenie] +comment: https://sourceforge.net/tracker/index.php?func=detail&aid=3510080&group_id=36855&atid=440764 +synonym: "copper ion import into ascospore-type prospore" EXACT [] +synonym: "copper ion uptake in ascospore-type prospore" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901639 +name: obsolete XDP catabolic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of XDP." [GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this reaction exist in vivo. +synonym: "XDP breakdown" EXACT [GOC:TermGenie] +synonym: "XDP catabolism" EXACT [GOC:TermGenie] +synonym: "XDP degradation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901640 +name: XTP binding +namespace: molecular_function +def: "Binding to XTP." [GOC:TermGenie] +is_a: GO:0032555 ! purine ribonucleotide binding +is_a: GO:0035639 ! purine ribonucleoside triphosphate binding + +[Term] +id: GO:1901641 +name: ITP binding +namespace: molecular_function +def: "Binding to ITP." [GOC:TermGenie] +is_a: GO:0032555 ! purine ribonucleotide binding +is_a: GO:0035639 ! purine ribonucleoside triphosphate binding + +[Term] +id: GO:1901642 +name: nucleoside transmembrane transport +namespace: biological_process +def: "The directed movement of nucleoside across a membrane." [GOC:pr, GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "nucleoside membrane transport" EXACT [] +is_a: GO:0015858 ! nucleoside transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1901643 +name: obsolete regulation of tRNA methylation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901644 +name: obsolete positive regulation of tRNA methylation in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of tRNA methylation in response to nitrogen starvation." [GOC:TermGenie] +synonym: "activation of tRNA methylation in response to nitrogen starvation" NARROW [GOC:TermGenie] +synonym: "up regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA methylation in response to nitrogen starvation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901645 +name: regulation of synoviocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0002941 ! synoviocyte proliferation + +[Term] +id: GO:1901646 +name: negative regulation of synoviocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] +synonym: "down regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of synoviocyte proliferation" NARROW [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1901645 ! regulation of synoviocyte proliferation +relationship: negatively_regulates GO:0002941 ! synoviocyte proliferation + +[Term] +id: GO:1901647 +name: positive regulation of synoviocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synoviocyte proliferation." [GOC:TermGenie] +synonym: "activation of synoviocyte proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of synoviocyte proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1901645 ! regulation of synoviocyte proliferation +relationship: positively_regulates GO:0002941 ! synoviocyte proliferation + +[Term] +id: GO:1901648 +name: regulation of actomyosin contractile ring localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] +synonym: "regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0032187 ! actomyosin contractile ring localization + +[Term] +id: GO:1901649 +name: negative regulation of actomyosin contractile ring localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] +synonym: "down regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "down regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "down regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "downregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "inhibition of actomyosin contractile ring localization" NARROW [GOC:TermGenie] +synonym: "inhibition of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "inhibition of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:1901648 ! regulation of actomyosin contractile ring localization +relationship: negatively_regulates GO:0032187 ! actomyosin contractile ring localization + +[Term] +id: GO:1901650 +name: positive regulation of actomyosin contractile ring localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actomyosin contractile ring localization." [GOC:TermGenie] +synonym: "activation of actomyosin contractile ring localization" NARROW [GOC:TermGenie] +synonym: "activation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "activation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "up regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "up regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "up regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "upregulation of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1901648 ! regulation of actomyosin contractile ring localization +relationship: positively_regulates GO:0032187 ! actomyosin contractile ring localization + +[Term] +id: GO:1901651 +name: regulation of mitotic chromosome decondensation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic chromosome decondensation." [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0007083 ! mitotic chromosome decondensation + +[Term] +id: GO:1901652 +name: response to peptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901653 +name: cellular response to peptide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus." [GOC:pr, GOC:TermGenie] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901652 ! response to peptide +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:1901654 +name: response to ketone +namespace: biological_process +alt_id: GO:1990369 +def: "A response that results in a state of tolerance to ketone." [GOC:mengo_curators, PMID:23356676] +synonym: "process resulting in tolerance to ketone" NARROW [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901655 +name: cellular response to ketone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] +is_a: GO:1901654 ! response to ketone +is_a: GO:1901701 ! cellular response to oxygen-containing compound + +[Term] +id: GO:1901656 +name: glycoside transport +namespace: biological_process +def: "The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:1901657 +name: glycosyl compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie] +synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie] +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:1901658 +name: glycosyl compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycosyl compound." [GOC:pr, GOC:TermGenie] +synonym: "glycosyl compound breakdown" EXACT [GOC:TermGenie] +synonym: "glycosyl compound catabolism" EXACT [GOC:TermGenie] +synonym: "glycosyl compound degradation" EXACT [GOC:TermGenie] +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:1901659 +name: glycosyl compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie] +synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie] +synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie] +synonym: "glycosyl compound formation" EXACT [GOC:TermGenie] +synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:1901657 ! glycosyl compound metabolic process + +[Term] +id: GO:1901660 +name: calcium ion export +namespace: biological_process +def: "The directed movement of calcium ion out of a cell or organelle." [GOC:TermGenie] +is_a: GO:0006816 ! calcium ion transport +is_a: GO:0070839 ! metal ion export + +[Term] +id: GO:1901661 +name: quinone metabolic process +namespace: biological_process +alt_id: GO:0042375 +def: "The chemical reactions and pathways involving quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie] +synonym: "quinone cofactor metabolic process" RELATED [] +synonym: "quinone cofactor metabolism" RELATED [] +synonym: "quinone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:1901662 +name: quinone catabolic process +namespace: biological_process +alt_id: GO:0042378 +def: "The chemical reactions and pathways resulting in the breakdown of quinone." [GOC:go_curators, GOC:pr, GOC:TermGenie] +synonym: "quinone breakdown" EXACT [GOC:TermGenie] +synonym: "quinone catabolism" EXACT [GOC:TermGenie] +synonym: "quinone cofactor breakdown" RELATED [] +synonym: "quinone cofactor catabolic process" RELATED [] +synonym: "quinone cofactor catabolism" RELATED [] +synonym: "quinone cofactor degradation" RELATED [] +synonym: "quinone degradation" EXACT [GOC:TermGenie] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1901663 +name: quinone biosynthetic process +namespace: biological_process +alt_id: GO:0045426 +def: "The chemical reactions and pathways resulting in the formation of quinone." [GOC:mb, GOC:pr, GOC:TermGenie] +synonym: "quinone anabolism" EXACT [GOC:TermGenie] +synonym: "quinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "quinone cofactor anabolism" RELATED [] +synonym: "quinone cofactor biosynthesis" RELATED [] +synonym: "quinone cofactor biosynthetic process" RELATED [] +synonym: "quinone cofactor formation" RELATED [] +synonym: "quinone cofactor synthesis" RELATED [] +synonym: "quinone formation" EXACT [GOC:TermGenie] +synonym: "quinone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1901664 +name: regulation of NAD+ ADP-ribosyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1901665 +name: negative regulation of NAD+ ADP-ribosyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "inhibition of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity + +[Term] +id: GO:1901666 +name: positive regulation of NAD+ ADP-ribosyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NAD+ ADP-ribosyltransferase activity." [GOC:BHF, GOC:TermGenie] +synonym: "activation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "activation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "activation of NAD+ ADP-ribosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "activation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "activation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "activation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "activation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ADP-ribosyltransferase (polymerizing) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD+ ADP-ribosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(adenosine diphosphate ribose) polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(ADP-ribose) synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(ADP-ribose) synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(ADP-ribose)polymerase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1901664 ! regulation of NAD+ ADP-ribosyltransferase activity + +[Term] +id: GO:1901667 +name: negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration." [GOC:dph, GOC:TermGenie, PMID:21272575] +synonym: "down regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of satellite cell activation involved in skeletal muscle regeneration" EXACT [GOC:TermGenie] +synonym: "inhibition of satellite cell activation involved in skeletal muscle regeneration" NARROW [GOC:TermGenie] +is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration +is_a: GO:0043417 ! negative regulation of skeletal muscle tissue regeneration +is_a: GO:0050866 ! negative regulation of cell activation +relationship: negatively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration + +[Term] +id: GO:1901668 +name: regulation of superoxide dismutase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] +synonym: "regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "regulation of SOD" RELATED [GOC:TermGenie] +synonym: "regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "regulation of SODF" RELATED [GOC:TermGenie] +synonym: "regulation of SODS" RELATED [GOC:TermGenie] +synonym: "regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1901670 +name: negative regulation of superoxide dismutase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] +synonym: "down regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "down regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "down regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "down regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "down regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "down regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "down regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "down regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "down regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "down regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down regulation of SOD" RELATED [GOC:TermGenie] +synonym: "down regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "down regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "down regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "down regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "down regulation of SODF" RELATED [GOC:TermGenie] +synonym: "down regulation of SODS" RELATED [GOC:TermGenie] +synonym: "down regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "down regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "down regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "down-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "down-regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "down-regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "down-regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "down-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "down-regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "down-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "down-regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "down-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "down-regulation of SOD" RELATED [GOC:TermGenie] +synonym: "down-regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "down-regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "down-regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "down-regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "down-regulation of SODF" RELATED [GOC:TermGenie] +synonym: "down-regulation of SODS" RELATED [GOC:TermGenie] +synonym: "down-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "down-regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "down-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "downregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "downregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cuprein" RELATED [GOC:TermGenie] +synonym: "downregulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "downregulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "downregulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "downregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "downregulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "downregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "downregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "downregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "downregulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "downregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "downregulation of SOD" RELATED [GOC:TermGenie] +synonym: "downregulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "downregulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "downregulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "downregulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "downregulation of SODF" RELATED [GOC:TermGenie] +synonym: "downregulation of SODS" RELATED [GOC:TermGenie] +synonym: "downregulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "downregulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "downregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "inhibition of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "inhibition of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cuprein" RELATED [GOC:TermGenie] +synonym: "inhibition of cytocuprein" RELATED [GOC:TermGenie] +synonym: "inhibition of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "inhibition of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "inhibition of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hemocuprein" RELATED [GOC:TermGenie] +synonym: "inhibition of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "inhibition of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "inhibition of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "inhibition of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "inhibition of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "inhibition of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "inhibition of SOD" RELATED [GOC:TermGenie] +synonym: "inhibition of SOD-1" RELATED [GOC:TermGenie] +synonym: "inhibition of SOD-2" RELATED [GOC:TermGenie] +synonym: "inhibition of SOD-3" RELATED [GOC:TermGenie] +synonym: "inhibition of SOD-4" RELATED [GOC:TermGenie] +synonym: "inhibition of SODF" RELATED [GOC:TermGenie] +synonym: "inhibition of SODS" RELATED [GOC:TermGenie] +synonym: "inhibition of superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "inhibition of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "inhibition of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "negative regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "negative regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "negative regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "negative regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "negative regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "negative regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "negative regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "negative regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "negative regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "negative regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "negative regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "negative regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "negative regulation of SOD" RELATED [GOC:TermGenie] +synonym: "negative regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "negative regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "negative regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "negative regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "negative regulation of SODF" RELATED [GOC:TermGenie] +synonym: "negative regulation of SODS" RELATED [GOC:TermGenie] +synonym: "negative regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "negative regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "negative regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1901668 ! regulation of superoxide dismutase activity +is_a: GO:1904832 ! negative regulation of removal of superoxide radicals + +[Term] +id: GO:1901671 +name: positive regulation of superoxide dismutase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of superoxide dismutase activity." [GOC:TermGenie] +synonym: "activation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "activation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of cuprein" RELATED [GOC:TermGenie] +synonym: "activation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "activation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "activation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "activation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "activation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "activation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "activation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "activation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "activation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "activation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "activation of SOD" RELATED [GOC:TermGenie] +synonym: "activation of SOD-1" RELATED [GOC:TermGenie] +synonym: "activation of SOD-2" RELATED [GOC:TermGenie] +synonym: "activation of SOD-3" RELATED [GOC:TermGenie] +synonym: "activation of SOD-4" RELATED [GOC:TermGenie] +synonym: "activation of SODF" RELATED [GOC:TermGenie] +synonym: "activation of SODS" RELATED [GOC:TermGenie] +synonym: "activation of superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "activation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "activation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "activation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "activation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "positive regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "positive regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "positive regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "positive regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "positive regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "positive regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "positive regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "positive regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "positive regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "positive regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "positive regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "positive regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "positive regulation of SOD" RELATED [GOC:TermGenie] +synonym: "positive regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "positive regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "positive regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "positive regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "positive regulation of SODF" RELATED [GOC:TermGenie] +synonym: "positive regulation of SODS" RELATED [GOC:TermGenie] +synonym: "positive regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "positive regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "positive regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "up regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "up regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "up regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "up regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "up regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "up regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "up regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "up regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "up regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up regulation of SOD" RELATED [GOC:TermGenie] +synonym: "up regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "up regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "up regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "up regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "up regulation of SODF" RELATED [GOC:TermGenie] +synonym: "up regulation of SODS" RELATED [GOC:TermGenie] +synonym: "up regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "up regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "up regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up-regulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "up-regulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of cuprein" RELATED [GOC:TermGenie] +synonym: "up-regulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "up-regulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "up-regulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "up-regulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "up-regulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "up-regulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up-regulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up-regulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "up-regulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "up-regulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "up-regulation of SOD" RELATED [GOC:TermGenie] +synonym: "up-regulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "up-regulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "up-regulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "up-regulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "up-regulation of SODF" RELATED [GOC:TermGenie] +synonym: "up-regulation of SODS" RELATED [GOC:TermGenie] +synonym: "up-regulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "up-regulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "up-regulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "upregulation of copper, zinc superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of Cu,Zn-SOD" RELATED [GOC:TermGenie] +synonym: "upregulation of Cu-Zn superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of cuprein" RELATED [GOC:TermGenie] +synonym: "upregulation of cytocuprein" RELATED [GOC:TermGenie] +synonym: "upregulation of erythrocuprein" RELATED [GOC:TermGenie] +synonym: "upregulation of Fe-SOD" RELATED [GOC:TermGenie] +synonym: "upregulation of ferrisuperoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hemocuprein" RELATED [GOC:TermGenie] +synonym: "upregulation of hepatocuprein" RELATED [GOC:TermGenie] +synonym: "upregulation of iron superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of iron superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "upregulation of manganese superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of manganese superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "upregulation of Mn, Fe superoxide dismutase" NARROW [GOC:TermGenie] +synonym: "upregulation of Mn-SOD" RELATED [GOC:TermGenie] +synonym: "upregulation of nickel superoxide dismutase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of nickel superoxide oxidoreductase" RELATED [GOC:TermGenie] +synonym: "upregulation of SOD" RELATED [GOC:TermGenie] +synonym: "upregulation of SOD-1" RELATED [GOC:TermGenie] +synonym: "upregulation of SOD-2" RELATED [GOC:TermGenie] +synonym: "upregulation of SOD-3" RELATED [GOC:TermGenie] +synonym: "upregulation of SOD-4" RELATED [GOC:TermGenie] +synonym: "upregulation of SODF" RELATED [GOC:TermGenie] +synonym: "upregulation of SODS" RELATED [GOC:TermGenie] +synonym: "upregulation of superoxide dismutase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of superoxide dismutase I" RELATED [GOC:TermGenie] +synonym: "upregulation of superoxide dismutase II" RELATED [GOC:TermGenie] +synonym: "upregulation of superoxide:superoxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of zinc superoxide oxidoreductase" RELATED [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1901668 ! regulation of superoxide dismutase activity + +[Term] +id: GO:1901672 +name: positive regulation of systemic acquired resistance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of systemic acquired resistance." [GOC:TermGenie] +synonym: "activation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] +synonym: "activation of systemic acquired resistance" NARROW [GOC:TermGenie] +synonym: "positive regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] +synonym: "up regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] +synonym: "up regulation of systemic acquired resistance" EXACT [GOC:TermGenie] +synonym: "up-regulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] +synonym: "up-regulation of systemic acquired resistance" EXACT [GOC:TermGenie] +synonym: "upregulation of salicylic acid-dependent systemic resistance" EXACT [GOC:TermGenie] +synonym: "upregulation of systemic acquired resistance" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0010112 ! regulation of systemic acquired resistance +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +relationship: positively_regulates GO:0009627 ! systemic acquired resistance + +[Term] +id: GO:1901673 +name: regulation of mitotic spindle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic spindle assembly." [GOC:TermGenie] +synonym: "regulation of spindle assembly involved in mitosis" EXACT [] +is_a: GO:0060236 ! regulation of mitotic spindle organization +is_a: GO:0090169 ! regulation of spindle assembly +relationship: regulates GO:0090307 ! mitotic spindle assembly + +[Term] +id: GO:1901674 +name: regulation of histone H3-K27 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] +synonym: "regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0043974 ! histone H3-K27 acetylation + +[Term] +id: GO:1901675 +name: negative regulation of histone H3-K27 acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] +synonym: "down regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3-K27 acetylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:1901674 ! regulation of histone H3-K27 acetylation +relationship: negatively_regulates GO:0043974 ! histone H3-K27 acetylation + +[Term] +id: GO:1901676 +name: positive regulation of histone H3-K27 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation." [GOC:BHF, GOC:TermGenie] +synonym: "activation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "activation of histone H3-K27 acetylation" NARROW [GOC:TermGenie] +synonym: "activation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3 acetylation at K27" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K27 acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3K27 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:1901674 ! regulation of histone H3-K27 acetylation +relationship: positively_regulates GO:0043974 ! histone H3-K27 acetylation + +[Term] +id: GO:1901678 +name: iron coordination entity transport +namespace: biological_process +def: "The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:pr, GOC:TermGenie] +is_a: GO:0006826 ! iron ion transport + +[Term] +id: GO:1901679 +name: nucleotide transmembrane transport +namespace: biological_process +def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +synonym: "nucleotide membrane transport" EXACT [] +is_a: GO:0006862 ! nucleotide transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1901680 +name: sulfur-containing amino acid secondary active transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of sulfur-containing amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:pr, GOC:TermGenie] +is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity +is_a: GO:0015291 ! secondary active transmembrane transporter activity + +[Term] +id: GO:1901681 +name: sulfur compound binding +namespace: molecular_function +def: "Binding to a sulfur compound." [GOC:pr, GOC:TermGenie] +synonym: "sulfur molecular entity binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1901682 +name: sulfur compound transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a sulfur compound from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "sulfur molecular entity transmembrane transporter activity" EXACT [] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901683 +name: arsenate ion transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of an arsenate ion from one side of a membrane to the other." [GOC:TermGenie] +is_a: GO:0008509 ! anion transmembrane transporter activity + +[Term] +id: GO:1901684 +name: arsenate ion transmembrane transport +namespace: biological_process +def: "The process in which arsenate is transported across a membrane." [GOC:TermGenie] +comment: Note that this term is not intended for use in annotating lateral movement within membranes. +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1901685 +name: glutathione derivative metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glutathione derivative." [GOC:pr, GOC:TermGenie] +synonym: "glutathione derivative metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1901686 +name: glutathione derivative catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glutathione derivative." [GOC:pr, GOC:TermGenie] +synonym: "glutathione derivative breakdown" EXACT [GOC:TermGenie] +synonym: "glutathione derivative catabolism" EXACT [GOC:TermGenie] +synonym: "glutathione derivative degradation" EXACT [GOC:TermGenie] +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901685 ! glutathione derivative metabolic process + +[Term] +id: GO:1901687 +name: glutathione derivative biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glutathione derivative." [GOC:pr, GOC:TermGenie] +synonym: "glutathione derivative anabolism" EXACT [GOC:TermGenie] +synonym: "glutathione derivative biosynthesis" EXACT [GOC:TermGenie] +synonym: "glutathione derivative formation" EXACT [GOC:TermGenie] +synonym: "glutathione derivative synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901685 ! glutathione derivative metabolic process + +[Term] +id: GO:1901691 +name: proton binding +namespace: molecular_function +def: "Binding to proton." [GOC:TermGenie] +synonym: "hydrogen ion binding" EXACT [GOC:bm] +is_a: GO:0043169 ! cation binding + +[Term] +id: GO:1901692 +name: regulation of compound eye retinal cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:1990010 ! compound eye retinal cell apoptotic process + +[Term] +id: GO:1901693 +name: negative regulation of compound eye retinal cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] +synonym: "down regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process +relationship: negatively_regulates GO:1990010 ! compound eye retinal cell apoptotic process + +[Term] +id: GO:1901694 +name: positive regulation of compound eye retinal cell apoptotic process +namespace: biological_process +alt_id: GO:0046675 +def: "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process." [GOC:mtg_apoptosis, GOC:TermGenie, PMID:12021768] +synonym: "activation of compound eye retinal cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "induction of compound eye retinal cell programmed cell death" RELATED [] +synonym: "up regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of compound eye retinal cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0046672 ! positive regulation of compound eye retinal cell programmed cell death +is_a: GO:1901692 ! regulation of compound eye retinal cell apoptotic process +relationship: positively_regulates GO:1990010 ! compound eye retinal cell apoptotic process + +[Term] +id: GO:1901695 +name: tyramine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyramine." [GOC:TermGenie, PMID:21284755] +synonym: "tyramine anabolism" EXACT [GOC:TermGenie] +synonym: "tyramine biosynthesis" EXACT [GOC:TermGenie] +synonym: "tyramine formation" EXACT [GOC:TermGenie] +synonym: "tyramine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901162 ! primary amino compound biosynthetic process + +[Term] +id: GO:1901696 +name: cannabinoid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cannabinoid." [GOC:TermGenie] +synonym: "cannabinoid anabolism" EXACT [GOC:TermGenie] +synonym: "cannabinoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "cannabinoid formation" EXACT [GOC:TermGenie] +synonym: "cannabinoid synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901576 ! organic substance biosynthetic process + +[Term] +id: GO:1901697 +name: olivetolic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of olivetolic acid." [GOC:TermGenie] +synonym: "olivetolic acid anabolism" EXACT [GOC:TermGenie] +synonym: "olivetolic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "olivetolic acid formation" EXACT [GOC:TermGenie] +synonym: "olivetolic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process + +[Term] +id: GO:1901698 +name: response to nitrogen compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] +synonym: "response to nitrogen molecular entity" EXACT [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1901699 +name: cellular response to nitrogen compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] +synonym: "cellular response to nitrogen molecular entity" EXACT [] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:1901700 +name: response to oxygen-containing compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] +synonym: "response to oxygen molecular entity" EXACT [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1901701 +name: cellular response to oxygen-containing compound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] +synonym: "cellular response to oxygen molecular entity" EXACT [] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1901702 +name: salt transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of salt from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +is_a: GO:0022857 ! transmembrane transporter activity + +[Term] +id: GO:1901703 +name: protein localization involved in auxin polar transport +namespace: biological_process +def: "Any protein localization that is involved in auxin polar transport." [GOC:TermGenie, PMID:23163883] +synonym: "establishment and maintenance of protein localization involved in auxin polar transport" EXACT [GOC:TermGenie] +synonym: "protein localisation involved in auxin polar transport" EXACT [GOC:TermGenie] +is_a: GO:0008104 ! protein localization +relationship: part_of GO:0009926 ! auxin polar transport + +[Term] +id: GO:1901704 +name: L-glutamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-glutamine." [GOC:TermGenie] +synonym: "L-glutamine anabolism" EXACT [GOC:TermGenie] +synonym: "L-glutamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "L-glutamine formation" EXACT [GOC:TermGenie] +synonym: "L-glutamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006542 ! glutamine biosynthetic process + +[Term] +id: GO:1901705 +name: L-isoleucine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-isoleucine." [GOC:TermGenie] +synonym: "L-isoleucine anabolism" EXACT [GOC:TermGenie] +synonym: "L-isoleucine biosynthesis" EXACT [GOC:TermGenie] +synonym: "L-isoleucine formation" EXACT [GOC:TermGenie] +synonym: "L-isoleucine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009067 ! aspartate family amino acid biosynthetic process +is_a: GO:0009097 ! isoleucine biosynthetic process + +[Term] +id: GO:1901706 +name: mesenchymal cell differentiation involved in bone development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state." [GOC:hjd, GOC:TermGenie, PMID:21571217] +is_a: GO:0048762 ! mesenchymal cell differentiation +relationship: part_of GO:0060348 ! bone development + +[Term] +id: GO:1901707 +name: leptomycin B binding +namespace: molecular_function +def: "Binding to leptomycin B." [GOC:TermGenie] +is_a: GO:0008289 ! lipid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1901708 +name: (+)-3'-hydroxylarreatricin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-3'-hydroxylarreatricin." [GOC:TermGenie, pmid:12960376] +synonym: "(+)-3'-hydroxylarreatricin anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-3'-hydroxylarreatricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-3'-hydroxylarreatricin formation" EXACT [GOC:TermGenie] +synonym: "(+)-3'-hydroxylarreatricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process + +[Term] +id: GO:1901709 +name: (+)-larreatricin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-larreatricin." [GOC:TermGenie, pmid:12960376] +synonym: "(+)-larreatricin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1901710 +name: regulation of homoserine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] +synonym: "regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "regulation of homoserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0009090 ! homoserine biosynthetic process + +[Term] +id: GO:1901711 +name: negative regulation of homoserine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] +synonym: "down regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of homoserine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of homoserine formation" EXACT [GOC:TermGenie] +synonym: "inhibition of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of homoserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901710 ! regulation of homoserine biosynthetic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0009090 ! homoserine biosynthetic process + +[Term] +id: GO:1901712 +name: positive regulation of homoserine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of homoserine biosynthetic process." [GOC:TermGenie] +synonym: "activation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "activation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of homoserine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "activation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of homoserine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of homoserine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of homoserine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of homoserine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of homoserine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of homoserine synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901710 ! regulation of homoserine biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:0009090 ! homoserine biosynthetic process + +[Term] +id: GO:1901713 +name: negative regulation of urea catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of urea catabolic process." [GOC:TermGenie] +synonym: "down regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "down regulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "down-regulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "downregulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of urea breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of urea catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of urea catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of urea decomposition" EXACT [GOC:TermGenie] +synonym: "inhibition of urea degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "negative regulation of urea degradation" EXACT [GOC:TermGenie] +is_a: GO:0034252 ! negative regulation of cellular amide catabolic process +is_a: GO:0034254 ! regulation of urea catabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1903315 ! negative regulation of nitrogen cycle metabolic process +relationship: negatively_regulates GO:0043419 ! urea catabolic process + +[Term] +id: GO:1901714 +name: positive regulation of urea catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of urea catabolic process." [GOC:TermGenie] +synonym: "activation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "activation of urea catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "activation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "activation of urea degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "positive regulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "up regulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of urea breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of urea catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of urea catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of urea decomposition" EXACT [GOC:TermGenie] +synonym: "upregulation of urea degradation" EXACT [GOC:TermGenie] +is_a: GO:0034253 ! positive regulation of cellular amide catabolic process +is_a: GO:0034254 ! regulation of urea catabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1903316 ! positive regulation of nitrogen cycle metabolic process +relationship: positively_regulates GO:0043419 ! urea catabolic process + +[Term] +id: GO:1901715 +name: regulation of gamma-aminobutyric acid catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] +synonym: "regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0009450 ! gamma-aminobutyric acid catabolic process + +[Term] +id: GO:1901716 +name: negative regulation of gamma-aminobutyric acid catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] +synonym: "down regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process +relationship: negatively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process + +[Term] +id: GO:1901717 +name: positive regulation of gamma-aminobutyric acid catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-aminobutyric acid catabolic process." [GOC:TermGenie] +synonym: "activation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "activation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "activation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "activation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "activation of gamma-aminobutyric acid catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "activation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of 4-aminobutanoate catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 4-aminobutanoate catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 4-aminobutyrate catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 4-aminobutyrate catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of GABA catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of GABA catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of gamma-aminobutyric acid breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of gamma-aminobutyric acid catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of gamma-aminobutyric acid catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of gamma-aminobutyric acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:1901715 ! regulation of gamma-aminobutyric acid catabolic process +relationship: positively_regulates GO:0009450 ! gamma-aminobutyric acid catabolic process + +[Term] +id: GO:1901718 +name: obsolete regulation of dipeptide transmembrane transport by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in regulation of dipeptide transmembrane transport." [GOC:TermGenie, GOC:vw] +comment: The term was obsoleted because it is better represented by a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1901719 +name: regulation of NMS complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] +synonym: "regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] +synonym: "regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +is_a: GO:0090234 ! regulation of kinetochore assembly +relationship: regulates GO:0044768 ! NMS complex assembly + +[Term] +id: GO:1901720 +name: negative regulation of NMS complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] +synonym: "down regulation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "downregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "downregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "downregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "downregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "inhibition of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "inhibition of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "inhibition of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "inhibition of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie] +synonym: "negative regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "negative regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "negative regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] +synonym: "negative regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +is_a: GO:1901719 ! regulation of NMS complex assembly +is_a: GO:1905560 ! negative regulation of kinetochore assembly +relationship: negatively_regulates GO:0044768 ! NMS complex assembly + +[Term] +id: GO:1901721 +name: positive regulation of NMS complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." [GOC:TermGenie, GOC:vw, PMID:22561345] +synonym: "activation of KMN complex assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "activation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "activation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "activation of NMS complex interaction involved in chromosome segregation" NARROW [GOC:TermGenie] +synonym: "positive regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "positive regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "positive regulation of NMS complex assembly involved in kinetochore assembly" EXACT [] +synonym: "positive regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of KMN complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of KMN network assembly involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of NMS complex association involved in chromosome segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of NMS complex interaction involved in chromosome segregation" EXACT [GOC:TermGenie] +is_a: GO:1901719 ! regulation of NMS complex assembly +is_a: GO:1905561 ! positive regulation of kinetochore assembly +relationship: positively_regulates GO:0044768 ! NMS complex assembly + +[Term] +id: GO:1901722 +name: regulation of cell proliferation involved in kidney development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0072111 ! cell proliferation involved in kidney development + +[Term] +id: GO:1901723 +name: negative regulation of cell proliferation involved in kidney development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] +synonym: "down regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +synonym: "inhibition of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development +relationship: negatively_regulates GO:0072111 ! cell proliferation involved in kidney development + +[Term] +id: GO:1901724 +name: positive regulation of cell proliferation involved in kidney development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in kidney development." [GOC:TermGenie, PMID:18182616] +synonym: "activation of cell proliferation involved in kidney development" NARROW [GOC:TermGenie] +synonym: "up regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +synonym: "upregulation of cell proliferation involved in kidney development" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development +relationship: positively_regulates GO:0072111 ! cell proliferation involved in kidney development + +[Term] +id: GO:1901725 +name: regulation of histone deacetylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +is_a: GO:0031063 ! regulation of histone deacetylation +is_a: GO:0150065 ! regulation of deacetylase activity + +[Term] +id: GO:1901726 +name: negative regulation of histone deacetylase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +synonym: "down regulation of histone deacetylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone deacetylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of histone deacetylase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of histone deacetylase activity" NARROW [GOC:TermGenie] +is_a: GO:0031064 ! negative regulation of histone deacetylation +is_a: GO:0150066 ! negative regulation of deacetylase activity +is_a: GO:1901725 ! regulation of histone deacetylase activity + +[Term] +id: GO:1901727 +name: positive regulation of histone deacetylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone deacetylase activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +synonym: "activation of histone deacetylase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of histone deacetylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone deacetylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of histone deacetylase activity" EXACT [GOC:TermGenie] +is_a: GO:0031065 ! positive regulation of histone deacetylation +is_a: GO:0090045 ! positive regulation of deacetylase activity +is_a: GO:1901725 ! regulation of histone deacetylase activity + +[Term] +id: GO:1901728 +name: monensin A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] +synonym: "monensin A metabolism" EXACT [GOC:TermGenie] +synonym: "monensin metabolism" EXACT [GOC:yaf] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901729 +name: monensin A catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] +synonym: "monensin A breakdown" EXACT [GOC:TermGenie] +synonym: "monensin A catabolism" EXACT [GOC:TermGenie] +synonym: "monensin A degradation" EXACT [GOC:TermGenie] +synonym: "monensin breakdown" EXACT [GOC:yaf] +synonym: "monensin catabolism" EXACT [GOC:yaf] +synonym: "monensin degradation" EXACT [GOC:yaf] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901728 ! monensin A metabolic process + +[Term] +id: GO:1901730 +name: monensin A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monensin A." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00178] +synonym: "monensin A anabolism" EXACT [GOC:TermGenie] +synonym: "monensin A biosynthesis" EXACT [GOC:TermGenie] +synonym: "monensin A formation" EXACT [GOC:TermGenie] +synonym: "monensin A synthesis" EXACT [GOC:TermGenie] +synonym: "monensin anabolism" EXACT [GOC:yaf] +synonym: "monensin biosynthesis" EXACT [GOC:yaf] +synonym: "monensin formation" EXACT [GOC:yaf] +synonym: "monensin synthesis" EXACT [GOC:yaf] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901728 ! monensin A metabolic process + +[Term] +id: GO:1901731 +name: positive regulation of platelet aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules." [GOC:fj, GOC:TermGenie] +synonym: "activation of blood platelet aggregation" NARROW [GOC:TermGenie] +synonym: "activation of platelet aggregation" NARROW [GOC:TermGenie] +synonym: "activation of thrombocyte aggregation" RELATED [GOC:TermGenie] +synonym: "positive regulation of blood platelet aggregation" EXACT [GOC:TermGenie] +synonym: "positive regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] +synonym: "up regulation of blood platelet aggregation" EXACT [GOC:TermGenie] +synonym: "up regulation of platelet aggregation" EXACT [GOC:TermGenie] +synonym: "up regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] +synonym: "up-regulation of blood platelet aggregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of platelet aggregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of thrombocyte aggregation" RELATED [GOC:TermGenie] +synonym: "upregulation of blood platelet aggregation" EXACT [GOC:TermGenie] +synonym: "upregulation of platelet aggregation" EXACT [GOC:TermGenie] +synonym: "upregulation of thrombocyte aggregation" RELATED [GOC:TermGenie] +is_a: GO:0034112 ! positive regulation of homotypic cell-cell adhesion +is_a: GO:0090330 ! regulation of platelet aggregation +relationship: positively_regulates GO:0070527 ! platelet aggregation + +[Term] +id: GO:1901732 +name: quercetin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] +synonym: "quercetin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051552 ! flavone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1901733 +name: quercetin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] +synonym: "quercetin breakdown" EXACT [GOC:TermGenie] +synonym: "quercetin catabolism" EXACT [GOC:TermGenie] +synonym: "quercetin degradation" EXACT [GOC:TermGenie] +is_a: GO:0046275 ! flavonoid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process +is_a: GO:1901732 ! quercetin metabolic process + +[Term] +id: GO:1901734 +name: quercetin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of quercetin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] +synonym: "quercetin anabolism" EXACT [GOC:TermGenie] +synonym: "quercetin biosynthesis" EXACT [GOC:TermGenie] +synonym: "quercetin formation" EXACT [GOC:TermGenie] +synonym: "quercetin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051553 ! flavone biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1901732 ! quercetin metabolic process + +[Term] +id: GO:1901735 +name: (R)-mevalonic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] +synonym: "(R) mevalonate metabolism" EXACT [GOC:yaf] +synonym: "(R)-mevalonic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1901736 +name: (R)-mevalonic acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] +synonym: "(R)-mevalonate breakdown" EXACT [MetaCyc:PWY-5074] +synonym: "(R)-mevalonate catabolism" EXACT [MetaCyc:PWY-5074] +synonym: "(R)-mevalonate degradation" EXACT [MetaCyc:PWY-5074] +synonym: "(R)-mevalonic acid breakdown" EXACT [GOC:TermGenie] +synonym: "(R)-mevalonic acid catabolism" EXACT [GOC:TermGenie] +synonym: "(R)-mevalonic acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process +is_a: GO:1901735 ! (R)-mevalonic acid metabolic process + +[Term] +id: GO:1901737 +name: (R)-mevalonic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (R)-mevalonic acid." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00058] +synonym: "(R)-mevalonate anabolism" EXACT [GOC:yaf] +synonym: "(R)-mevalonate biosynthesis" EXACT [GOC:yaf] +synonym: "(R)-mevalonate synthesis" EXACT [GOC:yaf] +synonym: "(R)-mevalonic acid anabolism" EXACT [GOC:TermGenie] +synonym: "(R)-mevalonic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "(R)-mevalonic acid formation" EXACT [GOC:TermGenie] +synonym: "(R)-mevalonic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1901735 ! (R)-mevalonic acid metabolic process + +[Term] +id: GO:1901738 +name: regulation of vitamin A metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vitamin A metabolic process." [GOC:TermGenie, PMID:18093975] +synonym: "regulation of vitamin A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0030656 ! regulation of vitamin metabolic process +relationship: regulates GO:0006776 ! vitamin A metabolic process + +[Term] +id: GO:1901739 +name: regulation of myoblast fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] +is_a: GO:0060142 ! regulation of syncytium formation by plasma membrane fusion +relationship: regulates GO:0007520 ! myoblast fusion + +[Term] +id: GO:1901740 +name: negative regulation of myoblast fusion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] +synonym: "down regulation of myoblast fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of myoblast fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of myoblast fusion" EXACT [GOC:TermGenie] +synonym: "inhibition of myoblast fusion" NARROW [GOC:TermGenie] +is_a: GO:0034242 ! negative regulation of syncytium formation by plasma membrane fusion +is_a: GO:1901739 ! regulation of myoblast fusion +relationship: negatively_regulates GO:0007520 ! myoblast fusion + +[Term] +id: GO:1901741 +name: positive regulation of myoblast fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myoblast fusion." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21364645] +synonym: "activation of myoblast fusion" NARROW [GOC:TermGenie] +synonym: "up regulation of myoblast fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of myoblast fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of myoblast fusion" EXACT [GOC:TermGenie] +is_a: GO:0060143 ! positive regulation of syncytium formation by plasma membrane fusion +is_a: GO:1901739 ! regulation of myoblast fusion +relationship: positively_regulates GO:0007520 ! myoblast fusion + +[Term] +id: GO:1901742 +name: 2-deoxystreptamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf] +synonym: "2-deoxystreptamine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:1901743 +name: 2-deoxystreptamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf] +synonym: "2-deoxystreptamine breakdown" EXACT [GOC:TermGenie] +synonym: "2-deoxystreptamine catabolism" EXACT [GOC:TermGenie] +synonym: "2-deoxystreptamine degradation" EXACT [GOC:TermGenie] +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901742 ! 2-deoxystreptamine metabolic process + +[Term] +id: GO:1901744 +name: 2-deoxystreptamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-deoxystreptamine." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00907] +synonym: "2-deoxystreptamine anabolism" EXACT [GOC:TermGenie] +synonym: "2-deoxystreptamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "2-deoxystreptamine formation" EXACT [GOC:TermGenie] +synonym: "2-deoxystreptamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901742 ! 2-deoxystreptamine metabolic process + +[Term] +id: GO:1901745 +name: prephenate(2-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890] +synonym: "prephenate metabolism" EXACT [GOC:yaf] +synonym: "prephenate(2-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043648 ! dicarboxylic acid metabolic process + +[Term] +id: GO:1901746 +name: prephenate(2-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890] +synonym: "prephenate breakdown" EXACT [GOC:yaf] +synonym: "prephenate catabolism" EXACT [GOC:yaf] +synonym: "prephenate degradation" EXACT [GOC:yaf] +synonym: "prephenate(2-) breakdown" EXACT [GOC:TermGenie] +synonym: "prephenate(2-) catabolism" EXACT [GOC:TermGenie] +synonym: "prephenate(2-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0043649 ! dicarboxylic acid catabolic process +is_a: GO:1901745 ! prephenate(2-) metabolic process + +[Term] +id: GO:1901747 +name: prephenate(2-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of prephenate(2-)." [GOC:TermGenie, GOC:yaf, PMID:16752890, UniPathway:UPA00120] +synonym: "prephenate anabolism" EXACT [GOC:yaf] +synonym: "prephenate biosynthesis" EXACT [GOC:yaf] +synonym: "prephenate formation" EXACT [GOC:yaf] +synonym: "prephenate synthesis" EXACT [GOC:yaf] +synonym: "prephenate(2-) anabolism" EXACT [GOC:TermGenie] +synonym: "prephenate(2-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "prephenate(2-) formation" EXACT [GOC:TermGenie] +synonym: "prephenate(2-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043650 ! dicarboxylic acid biosynthetic process +is_a: GO:1901745 ! prephenate(2-) metabolic process + +[Term] +id: GO:1901748 +name: leukotriene D4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leukotriene D4." [GOC:TermGenie, GOC:yaf] +synonym: "leukotriene D4 metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:1901749 +name: leukotriene D4 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of leukotriene D4." [GOC:TermGenie, GOC:yaf] +synonym: "leukotriene D4 breakdown" EXACT [GOC:TermGenie] +synonym: "leukotriene D4 catabolism" EXACT [GOC:TermGenie] +synonym: "leukotriene D4 degradation" EXACT [GOC:TermGenie] +is_a: GO:0036100 ! leukotriene catabolic process +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901523 ! icosanoid catabolic process +is_a: GO:1901748 ! leukotriene D4 metabolic process + +[Term] +id: GO:1901750 +name: leukotriene D4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leukotriene D4." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00880] +synonym: "leukotriene D4 anabolism" EXACT [GOC:TermGenie] +synonym: "leukotriene D4 biosynthesis" EXACT [GOC:TermGenie] +synonym: "leukotriene D4 formation" EXACT [GOC:TermGenie] +synonym: "leukotriene D4 synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019370 ! leukotriene biosynthetic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process +is_a: GO:1901748 ! leukotriene D4 metabolic process + +[Term] +id: GO:1901751 +name: leukotriene A4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving leukotriene A4." [GOC:TermGenie, GOC:yaf] +synonym: "leukotriene A4 metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0006691 ! leukotriene metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0097176 ! epoxide metabolic process +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:1901752 +name: leukotriene A4 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of leukotriene A4." [GOC:TermGenie, GOC:yaf] +synonym: "leukotriene A4 breakdown" EXACT [GOC:TermGenie] +synonym: "leukotriene A4 catabolism" EXACT [GOC:TermGenie] +synonym: "leukotriene A4 degradation" EXACT [GOC:TermGenie] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0036100 ! leukotriene catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901523 ! icosanoid catabolic process +is_a: GO:1901751 ! leukotriene A4 metabolic process + +[Term] +id: GO:1901753 +name: leukotriene A4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of leukotriene A4." [GOC:TermGenie, GOC:yaf, PMID:23242647] +synonym: "eoxin A4 biosynthesis" EXACT [] +synonym: "leukotriene A4 anabolism" EXACT [GOC:TermGenie] +synonym: "leukotriene A4 biosynthesis" EXACT [GOC:TermGenie] +synonym: "leukotriene A4 formation" EXACT [GOC:TermGenie] +synonym: "leukotriene A4 synthesis" EXACT [GOC:TermGenie] +synonym: "LTA4 biosynthesis" EXACT [] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019370 ! leukotriene biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901570 ! fatty acid derivative biosynthetic process +is_a: GO:1901751 ! leukotriene A4 metabolic process + +[Term] +id: GO:1901754 +name: vitamin D3 catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of vitamin D3." [GOC:TermGenie, GOC:yaf] +synonym: "calciol breakdown" EXACT [GOC:TermGenie] +synonym: "calciol catabolic process" EXACT [GOC:pr] +synonym: "calciol catabolism" EXACT [GOC:TermGenie] +synonym: "calciol degradation" EXACT [GOC:TermGenie] +synonym: "cholecalciferol catabolic process" EXACT [GOC:pr] +synonym: "cholecalciferol catabolism" EXACT [GOC:pr] +synonym: "vitamin D3 breakdown" EXACT [GOC:yaf] +synonym: "vitamin D3 catabolism" EXACT [GOC:yaf] +synonym: "vitamin D3 degradation" EXACT [GOC:yaf] +is_a: GO:0042369 ! vitamin D catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:0070640 ! vitamin D3 metabolic process + +[Term] +id: GO:1901755 +name: vitamin D3 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of vitamin D3." [GOC:TermGenie, GOC:yaf, Unipathway:UPA00955] +synonym: "calciol anabolism" EXACT [GOC:TermGenie] +synonym: "calciol biosynthesis" EXACT [GOC:TermGenie] +synonym: "calciol biosynthetic process" EXACT [GOC:pr] +synonym: "calciol formation" EXACT [GOC:TermGenie] +synonym: "calciol synthesis" EXACT [GOC:TermGenie] +synonym: "cholecalciferol biosynthesis" EXACT [GOC:pr] +synonym: "cholecalciferol biosynthetic process" EXACT [GOC:pr] +synonym: "vitamin D3 anabolism" EXACT [GOC:yaf] +synonym: "vitamin D3 biosynthesis" EXACT [GOC:yaf] +synonym: "vitamin D3 formation" EXACT [GOC:yaf] +synonym: "vitamin D3 synthesis" EXACT [GOC:yaf] +is_a: GO:0042368 ! vitamin D biosynthetic process +is_a: GO:0070640 ! vitamin D3 metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process + +[Term] +id: GO:1901756 +name: butirosin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving butirosin." [GOC:TermGenie, GOC:yaf] +synonym: "butirosin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016137 ! glycoside metabolic process +is_a: GO:0019751 ! polyol metabolic process + +[Term] +id: GO:1901757 +name: butirosin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of butirosin." [GOC:TermGenie, GOC:yaf] +synonym: "butirosin breakdown" EXACT [GOC:TermGenie] +synonym: "butirosin catabolism" EXACT [GOC:TermGenie] +synonym: "butirosin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:1901756 ! butirosin metabolic process + +[Term] +id: GO:1901758 +name: butirosin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of butirosin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00964] +synonym: "butirosin anabolism" EXACT [GOC:TermGenie] +synonym: "butirosin biosynthesis" EXACT [GOC:TermGenie] +synonym: "butirosin formation" EXACT [GOC:TermGenie] +synonym: "butirosin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:1901756 ! butirosin metabolic process + +[Term] +id: GO:1901759 +name: beta-L-Ara4N-lipid A metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-L-Ara4N-lipid A." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326] +synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolic process" EXACT [] +synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A metabolism" EXACT [] +synonym: "beta-L-Ara4N-lipid A metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006664 ! glycolipid metabolic process +is_a: GO:1901269 ! lipooligosaccharide metabolic process + +[Term] +id: GO:1901760 +name: beta-L-Ara4N-lipid A biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-L-Ara4N-lipid A which occurs as a result of modification of the lipid A moiety of lipopolysaccharide by the addition of the sugar 4-amino-4-deoxy-L-arabinose (L-Ara4N). This strategy is adopted by pathogenic Gram-negative bacteria to evade cationic antimicrobial peptides produced by the innate immune system." [GOC:TermGenie, GOC:yaf, PMID:17928292, PMID:19166326, UniPathway:UPA00037] +synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis" EXACT [] +synonym: "4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthetic process" EXACT [] +synonym: "beta-L-Ara4N-lipid A anabolism" EXACT [GOC:TermGenie] +synonym: "beta-L-Ara4N-lipid A biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-L-Ara4N-lipid A formation" EXACT [GOC:TermGenie] +synonym: "beta-L-Ara4N-lipid A synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0009247 ! glycolipid biosynthetic process +is_a: GO:1901271 ! lipooligosaccharide biosynthetic process +is_a: GO:1901759 ! beta-L-Ara4N-lipid A metabolic process + +[Term] +id: GO:1901761 +name: oxytetracycline metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168] +synonym: "oxytetracycline metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030638 ! polyketide metabolic process + +[Term] +id: GO:1901762 +name: oxytetracycline catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168] +synonym: "oxytetracycline breakdown" EXACT [GOC:TermGenie] +synonym: "oxytetracycline catabolism" EXACT [GOC:TermGenie] +synonym: "oxytetracycline degradation" EXACT [GOC:TermGenie] +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:1901761 ! oxytetracycline metabolic process + +[Term] +id: GO:1901763 +name: oxytetracycline biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of oxytetracycline." [GOC:TermGenie, GOC:yaf, PMID:8163168, UniPathway:UPA00926] +synonym: "oxytetracycline anabolism" EXACT [GOC:TermGenie] +synonym: "oxytetracycline biosynthesis" EXACT [GOC:TermGenie] +synonym: "oxytetracycline formation" EXACT [GOC:TermGenie] +synonym: "oxytetracycline synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:1901761 ! oxytetracycline metabolic process + +[Term] +id: GO:1901764 +name: phosphinothricin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphinothricin." [GOC:TermGenie, GOC:yaf] +synonym: "phosphinothricin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1901765 +name: phosphinothricin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of phosphinothricin." [GOC:TermGenie, GOC:yaf] +synonym: "phosphinothricin breakdown" EXACT [GOC:TermGenie] +synonym: "phosphinothricin catabolism" EXACT [GOC:TermGenie] +synonym: "phosphinothricin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009056 ! catabolic process +is_a: GO:1901764 ! phosphinothricin metabolic process + +[Term] +id: GO:1901766 +name: phosphinothricin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphinothricin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00168] +synonym: "phosphinothricin anabolism" EXACT [GOC:TermGenie] +synonym: "phosphinothricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "phosphinothricin formation" EXACT [GOC:TermGenie] +synonym: "phosphinothricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:1901764 ! phosphinothricin metabolic process + +[Term] +id: GO:1901767 +name: carbapenem metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024] +synonym: "carbapenem metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030653 ! beta-lactam antibiotic metabolic process + +[Term] +id: GO:1901768 +name: carbapenem catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024] +synonym: "carbapenem breakdown" EXACT [GOC:TermGenie] +synonym: "carbapenem catabolism" EXACT [GOC:TermGenie] +synonym: "carbapenem degradation" EXACT [GOC:TermGenie] +is_a: GO:0030655 ! beta-lactam antibiotic catabolic process +is_a: GO:1901767 ! carbapenem metabolic process + +[Term] +id: GO:1901769 +name: carbapenem biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of carbapenem." [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182] +synonym: "carbapenem anabolism" EXACT [GOC:TermGenie] +synonym: "carbapenem biosynthesis" EXACT [GOC:TermGenie] +synonym: "carbapenem formation" EXACT [GOC:TermGenie] +synonym: "carbapenem synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030654 ! beta-lactam antibiotic biosynthetic process +is_a: GO:1901767 ! carbapenem metabolic process + +[Term] +id: GO:1901770 +name: daunorubicin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857] +synonym: "daunorubicin breakdown" EXACT [GOC:TermGenie] +synonym: "daunorubicin catabolism" EXACT [GOC:TermGenie] +synonym: "daunorubicin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0030649 ! aminoglycoside antibiotic catabolic process +is_a: GO:0044597 ! daunorubicin metabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901662 ! quinone catabolic process + +[Term] +id: GO:1901771 +name: daunorubicin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of daunorubicin." [GOC:TermGenie, GOC:yaf, PMID:7601857, UniPathway:UPA00054] +synonym: "daunorubicin anabolism" EXACT [GOC:TermGenie] +synonym: "daunorubicin biosynthesis" EXACT [GOC:TermGenie] +synonym: "daunorubicin formation" EXACT [GOC:TermGenie] +synonym: "daunorubicin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process +is_a: GO:0044597 ! daunorubicin metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process + +[Term] +id: GO:1901772 +name: lincomycin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249] +synonym: "lincomycin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0016143 ! S-glycoside metabolic process +is_a: GO:0043603 ! cellular amide metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901773 +name: lincomycin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lincomycin." [GOC:TermGenie, GOC:yaf, PMID:8577249] +synonym: "lincomycin breakdown" EXACT [GOC:TermGenie] +synonym: "lincomycin catabolism" EXACT [GOC:TermGenie] +synonym: "lincomycin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016145 ! S-glycoside catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901772 ! lincomycin metabolic process + +[Term] +id: GO:1901774 +name: lincomycin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lincomycin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6955, PMID:8577249, UniPathway:UPA00161] +synonym: "lincomycin anabolism" EXACT [GOC:TermGenie] +synonym: "lincomycin biosynthesis" EXACT [GOC:TermGenie] +synonym: "lincomycin formation" EXACT [GOC:TermGenie] +synonym: "lincomycin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016144 ! S-glycoside biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:0043604 ! amide biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901772 ! lincomycin metabolic process + +[Term] +id: GO:1901775 +name: mitomycin C metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135] +synonym: "mitomycin C metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process +is_a: GO:1901661 ! quinone metabolic process + +[Term] +id: GO:1901776 +name: mitomycin C catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135] +synonym: "mitomycin C breakdown" EXACT [GOC:TermGenie] +synonym: "mitomycin C catabolism" EXACT [GOC:TermGenie] +synonym: "mitomycin C degradation" EXACT [GOC:TermGenie] +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901662 ! quinone catabolic process +is_a: GO:1901775 ! mitomycin C metabolic process + +[Term] +id: GO:1901777 +name: mitomycin C biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of mitomycin C." [GOC:TermGenie, GOC:yaf, PMID:10094699, PMID:10099135, UniPathway:UPA00851] +synonym: "mitomycin C anabolism" EXACT [GOC:TermGenie] +synonym: "mitomycin C biosynthesis" EXACT [GOC:TermGenie] +synonym: "mitomycin C formation" EXACT [GOC:TermGenie] +synonym: "mitomycin C synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901663 ! quinone biosynthetic process +is_a: GO:1901775 ! mitomycin C metabolic process + +[Term] +id: GO:1901778 +name: pentalenolactone metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094] +synonym: "pentalenolactone metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006714 ! sesquiterpenoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0097176 ! epoxide metabolic process +is_a: GO:1901334 ! lactone metabolic process + +[Term] +id: GO:1901779 +name: pentalenolactone catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pentalenolactone." [GOC:TermGenie, GOC:yaf, PMID:17178094] +synonym: "pentalenolactone breakdown" EXACT [GOC:TermGenie] +synonym: "pentalenolactone catabolism" EXACT [GOC:TermGenie] +synonym: "pentalenolactone degradation" EXACT [GOC:TermGenie] +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901335 ! lactone catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901778 ! pentalenolactone metabolic process + +[Term] +id: GO:1901780 +name: pentalenolactone biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of pentalenolactone." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6915, PMID:17178094, UniPathway:UPA00974] +synonym: "pentalenolactone anabolism" EXACT [GOC:TermGenie] +synonym: "pentalenolactone biosynthesis" EXACT [GOC:TermGenie] +synonym: "pentalenolactone formation" EXACT [GOC:TermGenie] +synonym: "pentalenolactone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901336 ! lactone biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901778 ! pentalenolactone metabolic process + +[Term] +id: GO:1901781 +name: p-cumate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713] +synonym: "p-cumate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1901782 +name: p-cumate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-cumate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5273, PMID:8631713, UniPathway:UPA00937] +synonym: "p-cumate breakdown" EXACT [GOC:TermGenie] +synonym: "p-cumate catabolism" EXACT [GOC:TermGenie] +synonym: "p-cumate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901781 ! p-cumate metabolic process + +[Term] +id: GO:1901783 +name: p-cumate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of p-cumate." [GOC:TermGenie, GOC:yaf, PMID:8631713] +synonym: "p-cumate anabolism" EXACT [GOC:TermGenie] +synonym: "p-cumate biosynthesis" EXACT [GOC:TermGenie] +synonym: "p-cumate formation" EXACT [GOC:TermGenie] +synonym: "p-cumate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901781 ! p-cumate metabolic process + +[Term] +id: GO:1901784 +name: p-cresol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531] +synonym: "p-cresol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042212 ! cresol metabolic process + +[Term] +id: GO:1901785 +name: p-cresol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531, UniPathway:UPA00708] +synonym: "p-cresol breakdown" EXACT [GOC:TermGenie] +synonym: "p-cresol catabolism" EXACT [GOC:TermGenie] +synonym: "p-cresol degradation" EXACT [GOC:TermGenie] +is_a: GO:0046199 ! cresol catabolic process +is_a: GO:1901784 ! p-cresol metabolic process + +[Term] +id: GO:1901786 +name: p-cresol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of p-cresol." [GOC:TermGenie, GOC:yaf, PMID:10623531] +synonym: "p-cresol anabolism" EXACT [GOC:TermGenie] +synonym: "p-cresol biosynthesis" EXACT [GOC:TermGenie] +synonym: "p-cresol formation" EXACT [GOC:TermGenie] +synonym: "p-cresol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901784 ! p-cresol metabolic process + +[Term] +id: GO:1901787 +name: benzoyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving benzoyl-CoA." [GOC:TermGenie, GOC:yaf] +synonym: "benzoyl-CoA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:1901788 +name: benzoyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of benzoyl-CoA." [GOC:TermGenie, GOC:yaf, MetaCyc:CENTBENZCOA-PWY, MetaCyc:P321-PWY, MetaCyc:PWY-1361, UniPathway:UPA00739] +synonym: "benzoyl-CoA breakdown" EXACT [GOC:TermGenie] +synonym: "benzoyl-CoA catabolism" EXACT [GOC:TermGenie] +synonym: "benzoyl-CoA degradation" EXACT [GOC:TermGenie] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901787 ! benzoyl-CoA metabolic process + +[Term] +id: GO:1901789 +name: benzoyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of benzoyl-CoA." [GOC:TermGenie, GOC:yaf] +synonym: "benzoyl-CoA anabolism" EXACT [GOC:TermGenie] +synonym: "benzoyl-CoA biosynthesis" EXACT [GOC:TermGenie] +synonym: "benzoyl-CoA formation" EXACT [GOC:TermGenie] +synonym: "benzoyl-CoA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071616 ! acyl-CoA biosynthetic process +is_a: GO:1901787 ! benzoyl-CoA metabolic process + +[Term] +id: GO:1901790 +name: 3-(2,3-dihydroxyphenyl)propanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY] +synonym: "3-(2,3-dihydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009712 ! catechol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:1901791 +name: 3-(2,3-dihydroxyphenyl)propanoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY, UniPathway:UPA00836] +synonym: "3-(2,3-dihydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] +synonym: "3-(2,3-dihydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] +synonym: "3-(2,3-dihydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019614 ! catechol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process + +[Term] +id: GO:1901792 +name: 3-(2,3-dihydroxyphenyl)propanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-(2,3-dihydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:1.13.11.16-RXN, MetaCyc:HCAMHPDEG-PWY] +synonym: "3-(2,3-dihydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie] +synonym: "3-(2,3-dihydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie] +synonym: "3-(2,3-dihydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie] +synonym: "3-(2,3-dihydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009713 ! catechol-containing compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901790 ! 3-(2,3-dihydroxyphenyl)propanoate metabolic process + +[Term] +id: GO:1901793 +name: 3-(3-hydroxyphenyl)propanoate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203] +synonym: "3-(3-hydroxyphenyl)propanoate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0032787 ! monocarboxylic acid metabolic process + +[Term] +id: GO:1901794 +name: 3-(3-hydroxyphenyl)propanoate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY0-1277, PMID:10537203, UniPathway:UPA00835] +synonym: "3-(3-hydroxyphenyl)propanoate breakdown" EXACT [GOC:TermGenie] +synonym: "3-(3-hydroxyphenyl)propanoate catabolism" EXACT [GOC:TermGenie] +synonym: "3-(3-hydroxyphenyl)propanoate degradation" EXACT [GOC:TermGenie] +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process + +[Term] +id: GO:1901795 +name: 3-(3-hydroxyphenyl)propanoate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-(3-hydroxyphenyl)propanoate." [GOC:TermGenie, GOC:yaf, PMID:10537203] +synonym: "3-(3-hydroxyphenyl)propanoate anabolism" EXACT [GOC:TermGenie] +synonym: "3-(3-hydroxyphenyl)propanoate biosynthesis" EXACT [GOC:TermGenie] +synonym: "3-(3-hydroxyphenyl)propanoate formation" EXACT [GOC:TermGenie] +synonym: "3-(3-hydroxyphenyl)propanoate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901793 ! 3-(3-hydroxyphenyl)propanoate metabolic process + +[Term] +id: GO:1901796 +name: regulation of signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0072331 ! signal transduction by p53 class mediator + +[Term] +id: GO:1901797 +name: negative regulation of signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] +synonym: "down regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "inhibition of signal transduction by p53 class mediator" NARROW [GOC:TermGenie] +is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0072331 ! signal transduction by p53 class mediator + +[Term] +id: GO:1901798 +name: positive regulation of signal transduction by p53 class mediator +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator." [GOC:TermGenie] +synonym: "activation of signal transduction by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "up regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0072331 ! signal transduction by p53 class mediator + +[Term] +id: GO:1901799 +name: negative regulation of proteasomal protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] +synonym: "down regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of proteasomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +is_a: GO:0061136 ! regulation of proteasomal protein catabolic process +is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process +relationship: negatively_regulates GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:1901800 +name: positive regulation of proteasomal protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] +synonym: "activation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] +is_a: GO:0061136 ! regulation of proteasomal protein catabolic process +is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process +relationship: positively_regulates GO:0010498 ! proteasomal protein catabolic process + +[Term] +id: GO:1901801 +name: 1,5-anhydro-D-fructose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] +synonym: "1,5-anhydro-D-fructose metabolism" EXACT [GOC:TermGenie] +is_a: GO:0005996 ! monosaccharide metabolic process +is_a: GO:0019751 ! polyol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0097176 ! epoxide metabolic process + +[Term] +id: GO:1901802 +name: 1,5-anhydro-D-fructose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] +synonym: "1,5-anhydro-D-fructose breakdown" EXACT [GOC:TermGenie] +synonym: "1,5-anhydro-D-fructose catabolism" EXACT [GOC:TermGenie] +synonym: "1,5-anhydro-D-fructose degradation" EXACT [GOC:TermGenie] +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046174 ! polyol catabolic process +is_a: GO:0046365 ! monosaccharide catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process + +[Term] +id: GO:1901803 +name: 1,5-anhydro-D-fructose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1,5-anhydro-D-fructose." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6992, PMID:15716041, UniPathway:UPA00738] +synonym: "1,5-anhydro-D-fructose anabolism" EXACT [GOC:TermGenie] +synonym: "1,5-anhydro-D-fructose biosynthesis" EXACT [GOC:TermGenie] +synonym: "1,5-anhydro-D-fructose formation" EXACT [GOC:TermGenie] +synonym: "1,5-anhydro-D-fructose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046173 ! polyol biosynthetic process +is_a: GO:0046364 ! monosaccharide biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901801 ! 1,5-anhydro-D-fructose metabolic process + +[Term] +id: GO:1901804 +name: beta-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] +synonym: "beta-glucoside metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:1901805 +name: beta-glucoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] +synonym: "beta-glucoside breakdown" EXACT [GOC:TermGenie] +synonym: "beta-glucoside catabolism" EXACT [GOC:TermGenie] +synonym: "beta-glucoside degradation" EXACT [GOC:TermGenie] +is_a: GO:0016139 ! glycoside catabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1901806 +name: beta-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-glucoside." [GOC:TermGenie, GOC:yaf, PMID:15205427, PMID:16390337, PMID:8990303, Unipathway:UPA00237] +synonym: "beta-glucoside anabolism" EXACT [GOC:TermGenie] +synonym: "beta-glucoside biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-glucoside formation" EXACT [GOC:TermGenie] +synonym: "beta-glucoside synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1901807 +name: capsanthin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] +synonym: "capsanthin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:1901808 +name: capsanthin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] +synonym: "capsanthin breakdown" EXACT [GOC:TermGenie] +synonym: "capsanthin catabolism" EXACT [GOC:TermGenie] +synonym: "capsanthin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:1901807 ! capsanthin metabolic process + +[Term] +id: GO:1901809 +name: capsanthin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of capsanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, PMID:10995282, UniPathway:UPA00806] +synonym: "capsanthin anabolism" EXACT [GOC:TermGenie] +synonym: "capsanthin biosynthesis" EXACT [GOC:TermGenie] +synonym: "capsanthin formation" EXACT [GOC:TermGenie] +synonym: "capsanthin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:1901807 ! capsanthin metabolic process + +[Term] +id: GO:1901810 +name: beta-carotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] +synonym: "beta-carotene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901811 +name: beta-carotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] +synonym: "beta-carotene breakdown" EXACT [GOC:TermGenie] +synonym: "beta-carotene catabolism" EXACT [GOC:TermGenie] +synonym: "beta-carotene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901810 ! beta-carotene metabolic process + +[Term] +id: GO:1901812 +name: beta-carotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5943, PMID:11387982, UniPathway:UPA00802] +synonym: "beta-carotene anabolism" EXACT [GOC:TermGenie] +synonym: "beta-carotene biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-carotene formation" EXACT [GOC:TermGenie] +synonym: "beta-carotene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901810 ! beta-carotene metabolic process + +[Term] +id: GO:1901813 +name: astaxanthin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] +synonym: "astaxanthin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:1901814 +name: astaxanthin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] +synonym: "astaxanthin breakdown" EXACT [GOC:TermGenie] +synonym: "astaxanthin catabolism" EXACT [GOC:TermGenie] +synonym: "astaxanthin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:1901813 ! astaxanthin metabolic process + +[Term] +id: GO:1901815 +name: astaxanthin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of astaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5288, PMID:16434154, UniPathway:UPA00387] +synonym: "astaxanthin anabolism" EXACT [GOC:TermGenie] +synonym: "astaxanthin biosynthesis" EXACT [GOC:TermGenie] +synonym: "astaxanthin formation" EXACT [GOC:TermGenie] +synonym: "astaxanthin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:1901813 ! astaxanthin metabolic process + +[Term] +id: GO:1901816 +name: beta-zeacarotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] +synonym: "beta-zeacarotene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901817 +name: beta-zeacarotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] +synonym: "beta-zeacarotene breakdown" EXACT [GOC:TermGenie] +synonym: "beta-zeacarotene catabolism" EXACT [GOC:TermGenie] +synonym: "beta-zeacarotene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901816 ! beta-zeacarotene metabolic process + +[Term] +id: GO:1901818 +name: beta-zeacarotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:3710717, UniPathway:UPA00805] +synonym: "beta-zeacarotene anabolism" EXACT [GOC:TermGenie] +synonym: "beta-zeacarotene biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-zeacarotene formation" EXACT [GOC:TermGenie] +synonym: "beta-zeacarotene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901816 ! beta-zeacarotene metabolic process + +[Term] +id: GO:1901819 +name: alpha-zeacarotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] +synonym: "alpha-zeacarotene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901820 +name: alpha-zeacarotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] +synonym: "alpha-zeacarotene breakdown" EXACT [GOC:TermGenie] +synonym: "alpha-zeacarotene catabolism" EXACT [GOC:TermGenie] +synonym: "alpha-zeacarotene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901819 ! alpha-zeacarotene metabolic process + +[Term] +id: GO:1901821 +name: alpha-zeacarotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-zeacarotene." [GOC:TermGenie, GOC:yaf, PMID:6060456, UniPathway:UPA00804] +synonym: "alpha-zeacarotene anabolism" EXACT [GOC:TermGenie] +synonym: "alpha-zeacarotene biosynthesis" EXACT [GOC:TermGenie] +synonym: "alpha-zeacarotene formation" EXACT [GOC:TermGenie] +synonym: "alpha-zeacarotene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901819 ! alpha-zeacarotene metabolic process + +[Term] +id: GO:1901822 +name: delta-carotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] +synonym: "delta-carotene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:0016119 ! carotene metabolic process + +[Term] +id: GO:1901823 +name: delta-carotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] +synonym: "delta-carotene breakdown" EXACT [GOC:TermGenie] +synonym: "delta-carotene catabolism" EXACT [GOC:TermGenie] +synonym: "delta-carotene degradation" EXACT [GOC:TermGenie] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:0016121 ! carotene catabolic process +is_a: GO:1901822 ! delta-carotene metabolic process + +[Term] +id: GO:1901824 +name: delta-carotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of delta-carotene." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5946, PMID:8837512, UniPathway:UPA00801] +synonym: "delta-carotene anabolism" EXACT [GOC:TermGenie] +synonym: "delta-carotene biosynthesis" EXACT [GOC:TermGenie] +synonym: "delta-carotene formation" EXACT [GOC:TermGenie] +synonym: "delta-carotene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:0016120 ! carotene biosynthetic process +is_a: GO:1901822 ! delta-carotene metabolic process + +[Term] +id: GO:1901825 +name: zeaxanthin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] +synonym: "zeaxanthin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:1901826 +name: zeaxanthin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] +synonym: "zeaxanthin breakdown" EXACT [GOC:TermGenie] +synonym: "zeaxanthin catabolism" EXACT [GOC:TermGenie] +synonym: "zeaxanthin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:1901825 ! zeaxanthin metabolic process + +[Term] +id: GO:1901827 +name: zeaxanthin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zeaxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5944, UniPathway:UPA00843] +synonym: "zeaxanthin anabolism" EXACT [GOC:TermGenie] +synonym: "zeaxanthin biosynthesis" EXACT [GOC:TermGenie] +synonym: "zeaxanthin formation" EXACT [GOC:TermGenie] +synonym: "zeaxanthin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:1901825 ! zeaxanthin metabolic process + +[Term] +id: GO:1901828 +name: zeaxanthin bis(beta-D-glucoside) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] +synonym: "zeaxanthin bis(beta-D-glucoside) metabolism" EXACT [GOC:TermGenie] +synonym: "zeaxanthin diglucoside metabolism" EXACT [GOC:yaf] +is_a: GO:0016116 ! carotenoid metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1901829 +name: zeaxanthin bis(beta-D-glucoside) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] +synonym: "zeaxanthin bis(beta-D-glucoside) breakdown" EXACT [GOC:TermGenie] +synonym: "zeaxanthin bis(beta-D-glucoside) catabolism" EXACT [GOC:TermGenie] +synonym: "zeaxanthin bis(beta-D-glucoside) degradation" EXACT [GOC:TermGenie] +synonym: "zeaxanthin diglucoside breakdown" EXACT [GOC:yaf] +synonym: "zeaxanthin diglucoside catabolism" EXACT [GOC:yaf] +synonym: "zeaxanthin diglucoside degradation" EXACT [GOC:yaf] +is_a: GO:0016118 ! carotenoid catabolic process +is_a: GO:1901805 ! beta-glucoside catabolic process +is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process + +[Term] +id: GO:1901830 +name: zeaxanthin bis(beta-D-glucoside) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of zeaxanthin bis(beta-D-glucoside)." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6288, PMID:20075616, UniPathway:UPA00798] +synonym: "zeaxanthin bis(beta-D-glucoside) anabolism" EXACT [GOC:TermGenie] +synonym: "zeaxanthin bis(beta-D-glucoside) biosynthesis" EXACT [GOC:TermGenie] +synonym: "zeaxanthin bis(beta-D-glucoside) formation" EXACT [GOC:TermGenie] +synonym: "zeaxanthin bis(beta-D-glucoside) synthesis" EXACT [GOC:TermGenie] +synonym: "zeaxanthin diglucoside anabolism" EXACT [GOC:yaf] +synonym: "zeaxanthin diglucoside biosynthesis" EXACT [GOC:yaf] +synonym: "zeaxanthin diglucoside formation" EXACT [GOC:yaf] +synonym: "zeaxanthin diglucoside synthesis" EXACT [GOC:yaf] +is_a: GO:0016117 ! carotenoid biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process +is_a: GO:1901828 ! zeaxanthin bis(beta-D-glucoside) metabolic process + +[Term] +id: GO:1901831 +name: all-trans-neoxanthin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] +synonym: "all-trans-neoxanthin metabolism" EXACT [GOC:TermGenie] +synonym: "neoxanthin metabolic process" EXACT [GOC:yaf] +synonym: "neoxanthin metabolism" EXACT [GOC:yaf] +is_a: GO:0016122 ! xanthophyll metabolic process +is_a: GO:0097176 ! epoxide metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:1901832 +name: all-trans-neoxanthin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] +synonym: "all-trans-neoxanthin breakdown" EXACT [GOC:TermGenie] +synonym: "all-trans-neoxanthin catabolism" EXACT [GOC:TermGenie] +synonym: "all-trans-neoxanthin degradation" EXACT [GOC:TermGenie] +synonym: "neoxanthin breakdown" EXACT [GOC:yaf] +synonym: "neoxanthin catabolic process" EXACT [GOC:yaf] +synonym: "neoxanthin catabolism" EXACT [GOC:yaf] +synonym: "neoxanthin degradation" EXACT [GOC:yaf] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901831 ! all-trans-neoxanthin metabolic process + +[Term] +id: GO:1901833 +name: all-trans-neoxanthin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of all-trans-neoxanthin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-6809, PMID:11029576, UniPathway:UPA00388] +synonym: "all-trans-neoxanthin anabolism" EXACT [GOC:TermGenie] +synonym: "all-trans-neoxanthin biosynthesis" EXACT [GOC:TermGenie] +synonym: "all-trans-neoxanthin formation" EXACT [GOC:TermGenie] +synonym: "all-trans-neoxanthin synthesis" EXACT [GOC:TermGenie] +synonym: "neoxanthin anabolism" EXACT [GOC:yaf] +synonym: "neoxanthin biosynthesis" EXACT [GOC:yaf] +synonym: "neoxanthin biosynthetic process" EXACT [GOC:yaf] +synonym: "neoxanthin formation" EXACT [GOC:yaf] +synonym: "neoxanthin synthesis" EXACT [GOC:yaf] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1901831 ! all-trans-neoxanthin metabolic process + +[Term] +id: GO:1901834 +name: regulation of deadenylation-independent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie] +synonym: "regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA + +[Term] +id: GO:1901835 +name: positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA." [GOC:TermGenie] +synonym: "activation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "activation of deadenylation-independent decapping of nuclear-transcribed mRNA" NARROW [GOC:TermGenie] +synonym: "activation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +synonym: "positive regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "positive regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +synonym: "up regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +synonym: "up-regulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +synonym: "upregulation of deadenylation-independent decapping of nuclear mRNA" RELATED [GOC:TermGenie] +synonym: "upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of deadenylylation-independent decapping" EXACT [GOC:TermGenie] +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:1901834 ! regulation of deadenylation-independent decapping of nuclear-transcribed mRNA +relationship: positively_regulates GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA + +[Term] +id: GO:1901836 +name: regulation of transcription of nucleolar large rRNA by RNA polymerase I +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] +synonym: "regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] +synonym: "regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +is_a: GO:0006356 ! regulation of transcription by RNA polymerase I +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I + +[Term] +id: GO:1901837 +name: negative regulation of transcription of nucleolar large rRNA by RNA polymerase I +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription of nuclear large rRNA transcript mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] +synonym: "down regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] +synonym: "negative regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I +is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I +relationship: negatively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I + +[Term] +id: GO:1901838 +name: positive regulation of transcription of nucleolar large rRNA by RNA polymerase I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription of nuclear large rRNA mediated by RNA polymerase I." [GOC:sart, GOC:TermGenie] +synonym: "activation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" NARROW [GOC:TermGenie] +synonym: "activation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [] +synonym: "positive regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription of nuclear rRNA large Pol I transcript" EXACT [GOC:TermGenie] +is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I +is_a: GO:1901836 ! regulation of transcription of nucleolar large rRNA by RNA polymerase I +relationship: positively_regulates GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I + +[Term] +id: GO:1901839 +name: regulation of RNA polymerase I regulatory region sequence-specific DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie] +is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1901840 +name: negative regulation of RNA polymerase I regulatory region sequence-specific DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase I regulatory region sequence-specific DNA binding." [GOC:sart, GOC:TermGenie] +synonym: "down regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA polymerase I regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA polymerase I regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] +is_a: GO:1901839 ! regulation of RNA polymerase I regulatory region sequence-specific DNA binding +is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1901841 +name: regulation of high voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] +synonym: "regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity + +[Term] +id: GO:1901842 +name: negative regulation of high voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] +synonym: "down regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901386 ! negative regulation of voltage-gated calcium channel activity +is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity + +[Term] +id: GO:1901843 +name: positive regulation of high voltage-gated calcium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of high voltage-gated calcium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254] +synonym: "activation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "activation of high voltage-gated calcium channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of high voltage gated calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of high voltage-dependent calcium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of high voltage-gated calcium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901387 ! positive regulation of voltage-gated calcium channel activity +is_a: GO:1901841 ! regulation of high voltage-gated calcium channel activity + +[Term] +id: GO:1901844 +name: regulation of cell communication by electrical coupling involved in cardiac conduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] +is_a: GO:0010649 ! regulation of cell communication by electrical coupling +relationship: regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction + +[Term] +id: GO:1901845 +name: negative regulation of cell communication by electrical coupling involved in cardiac conduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] +synonym: "down regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +synonym: "downregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +synonym: "inhibition of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie] +is_a: GO:0010651 ! negative regulation of cell communication by electrical coupling +is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction +relationship: negatively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction + +[Term] +id: GO:1901846 +name: positive regulation of cell communication by electrical coupling involved in cardiac conduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302] +synonym: "activation of cell communication by electrical coupling involved in cardiac conduction" NARROW [GOC:TermGenie] +synonym: "up regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +synonym: "upregulation of cell communication by electrical coupling involved in cardiac conduction" EXACT [GOC:TermGenie] +is_a: GO:0010650 ! positive regulation of cell communication by electrical coupling +is_a: GO:1901844 ! regulation of cell communication by electrical coupling involved in cardiac conduction +relationship: positively_regulates GO:0086064 ! cell communication by electrical coupling involved in cardiac conduction + +[Term] +id: GO:1901847 +name: nicotinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] +synonym: "nicotinate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0009820 ! alkaloid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:1901848 +name: nicotinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] +synonym: "nicotinate breakdown" EXACT [GOC:TermGenie] +synonym: "nicotinate catabolism" EXACT [GOC:TermGenie] +synonym: "nicotinate degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:0072526 ! pyridine-containing compound catabolic process +is_a: GO:1901847 ! nicotinate metabolic process + +[Term] +id: GO:1901849 +name: nicotinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of nicotinate." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00830] +synonym: "nicotinate anabolism" EXACT [GOC:TermGenie] +synonym: "nicotinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "nicotinate formation" EXACT [GOC:TermGenie] +synonym: "nicotinate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009821 ! alkaloid biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process +is_a: GO:1901847 ! nicotinate metabolic process + +[Term] +id: GO:1901850 +name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolism" EXACT [GOC:TermGenie] +synonym: "coenzyme F0 metabolism" EXACT [GOC:yaf] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process +is_a: GO:1901564 ! organonitrogen compound metabolic process + +[Term] +id: GO:1901851 +name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin breakdown" EXACT [GOC:TermGenie] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolism" EXACT [GOC:TermGenie] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin degradation" EXACT [GOC:TermGenie] +synonym: "coenzyme F0 breakdown" EXACT [GOC:yaf] +synonym: "coenzyme F0 catabolic process" EXACT [GOC:yaf] +synonym: "coenzyme F0 catabolism" EXACT [GOC:yaf] +synonym: "coenzyme F0 degradation" EXACT [GOC:yaf] +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901565 ! organonitrogen compound catabolic process +is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process + +[Term] +id: GO:1901852 +name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 7,8-didemethyl-8-hydroxy-5-deazariboflavin." [GOC:TermGenie, GOC:yaf, PMID:14593448, UniPathway:UPA00072] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin anabolism" EXACT [GOC:TermGenie] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis" EXACT [GOC:TermGenie] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin formation" EXACT [GOC:TermGenie] +synonym: "7,8-didemethyl-8-hydroxy-5-deazariboflavin synthesis" EXACT [GOC:TermGenie] +synonym: "coenzyme F0 anabolism" EXACT [GOC:yaf] +synonym: "coenzyme F0 biosynthesis" EXACT [GOC:yaf] +synonym: "coenzyme F0 biosynthetic process" EXACT [GOC:yaf] +synonym: "coenzyme F0 formation" EXACT [GOC:yaf] +synonym: "coenzyme F0 synthesis" EXACT [GOC:yaf] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1901850 ! 7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process + +[Term] +id: GO:1901853 +name: 5,6,7,8-tetrahydrosarcinapterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] +synonym: "5,6,7,8-tetrahydrosarcinapterin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0072350 ! tricarboxylic acid metabolic process +is_a: GO:2001117 ! tetrahydromethanopterin metabolic process + +[Term] +id: GO:1901854 +name: 5,6,7,8-tetrahydrosarcinapterin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] +synonym: "5,6,7,8-tetrahydrosarcinapterin breakdown" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydrosarcinapterin catabolism" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydrosarcinapterin degradation" EXACT [GOC:TermGenie] +is_a: GO:0042560 ! pteridine-containing compound catabolic process +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:0072352 ! tricarboxylic acid catabolic process +is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process + +[Term] +id: GO:1901855 +name: 5,6,7,8-tetrahydrosarcinapterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5,6,7,8-tetrahydrosarcinapterin." [GOC:TermGenie, GOC:yaf, UniPathway:UPA00069] +synonym: "5,6,7,8-tetrahydrosarcinapterin anabolism" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydrosarcinapterin biosynthesis" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydrosarcinapterin formation" EXACT [GOC:TermGenie] +synonym: "5,6,7,8-tetrahydrosarcinapterin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process +is_a: GO:1901853 ! 5,6,7,8-tetrahydrosarcinapterin metabolic process +is_a: GO:2001118 ! tetrahydromethanopterin biosynthetic process + +[Term] +id: GO:1901856 +name: negative regulation of cellular respiration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "down regulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of respiration" BROAD [GOC:TermGenie] +synonym: "down-regulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of respiration" BROAD [GOC:TermGenie] +synonym: "downregulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of respiration" BROAD [GOC:TermGenie] +synonym: "inhibition of cellular respiration" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of respiration" BROAD [GOC:TermGenie] +synonym: "negative regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of respiration" BROAD [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +relationship: negatively_regulates GO:0045333 ! cellular respiration + +[Term] +id: GO:1901857 +name: positive regulation of cellular respiration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular respiration." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "activation of cellular respiration" NARROW [GOC:TermGenie] +synonym: "activation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "activation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "activation of respiration" BROAD [GOC:TermGenie] +synonym: "positive regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of respiration" BROAD [GOC:TermGenie] +synonym: "up regulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of respiration" BROAD [GOC:TermGenie] +synonym: "up-regulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of respiration" BROAD [GOC:TermGenie] +synonym: "upregulation of cellular respiration" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidative metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidative metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of respiration" BROAD [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0043457 ! regulation of cellular respiration +relationship: positively_regulates GO:0045333 ! cellular respiration + +[Term] +id: GO:1901858 +name: regulation of mitochondrial DNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:1901859 +name: negative regulation of mitochondrial DNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "down regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process +relationship: negatively_regulates GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:1901860 +name: positive regulation of mitochondrial DNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "activation of mitochondrial DNA metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "activation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "activation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mtDNA metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial DNA metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial DNA metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mtDNA metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mtDNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:1901858 ! regulation of mitochondrial DNA metabolic process +relationship: positively_regulates GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:1901861 +name: regulation of muscle tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060537 ! muscle tissue development + +[Term] +id: GO:1901862 +name: negative regulation of muscle tissue development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "down regulation of muscle tissue development" EXACT [GOC:TermGenie] +synonym: "down-regulation of muscle tissue development" EXACT [GOC:TermGenie] +synonym: "downregulation of muscle tissue development" EXACT [GOC:TermGenie] +synonym: "inhibition of muscle tissue development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901861 ! regulation of muscle tissue development +relationship: negatively_regulates GO:0060537 ! muscle tissue development + +[Term] +id: GO:1901863 +name: positive regulation of muscle tissue development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle tissue development." [GOC:TermGenie, GOC:yaf, PMID:23150719] +synonym: "activation of muscle tissue development" NARROW [GOC:TermGenie] +synonym: "up regulation of muscle tissue development" EXACT [GOC:TermGenie] +synonym: "up-regulation of muscle tissue development" EXACT [GOC:TermGenie] +synonym: "upregulation of muscle tissue development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1901861 ! regulation of muscle tissue development +relationship: positively_regulates GO:0060537 ! muscle tissue development + +[Term] +id: GO:1901864 +name: capsorubin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] +synonym: "capsorubin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016122 ! xanthophyll metabolic process + +[Term] +id: GO:1901865 +name: capsorubin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] +synonym: "capsorubin breakdown" EXACT [GOC:TermGenie] +synonym: "capsorubin catabolism" EXACT [GOC:TermGenie] +synonym: "capsorubin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016124 ! xanthophyll catabolic process +is_a: GO:1901864 ! capsorubin metabolic process + +[Term] +id: GO:1901866 +name: capsorubin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of capsorubin." [GOC:TermGenie, GOC:yaf, MetaCyc:PWY-5174, UniPathway:UPA00807] +synonym: "capsorubin anabolism" EXACT [GOC:TermGenie] +synonym: "capsorubin biosynthesis" EXACT [GOC:TermGenie] +synonym: "capsorubin formation" EXACT [GOC:TermGenie] +synonym: "capsorubin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016123 ! xanthophyll biosynthetic process +is_a: GO:1901864 ! capsorubin metabolic process + +[Term] +id: GO:1901867 +name: ecgonine methyl ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonine methyl ester metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046448 ! tropane alkaloid metabolic process + +[Term] +id: GO:1901868 +name: ecgonine methyl ester catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonine methyl ester breakdown" EXACT [GOC:TermGenie] +synonym: "ecgonine methyl ester catabolism" EXACT [GOC:TermGenie] +synonym: "ecgonine methyl ester degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901867 ! ecgonine methyl ester metabolic process + +[Term] +id: GO:1901869 +name: ecgonine methyl ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecgonine methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonine methyl ester anabolism" EXACT [GOC:TermGenie] +synonym: "ecgonine methyl ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "ecgonine methyl ester formation" EXACT [GOC:TermGenie] +synonym: "ecgonine methyl ester synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009710 ! tropane alkaloid biosynthetic process +is_a: GO:1901867 ! ecgonine methyl ester metabolic process + +[Term] +id: GO:1901870 +name: ecgonone methyl ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonone methyl ester metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046448 ! tropane alkaloid metabolic process + +[Term] +id: GO:1901871 +name: ecgonone methyl ester catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonone methyl ester breakdown" EXACT [GOC:TermGenie] +synonym: "ecgonone methyl ester catabolism" EXACT [GOC:TermGenie] +synonym: "ecgonone methyl ester degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901870 ! ecgonone methyl ester metabolic process + +[Term] +id: GO:1901872 +name: ecgonone methyl ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ecgonone methyl ester." [GOC:TermGenie, PMID:22665766] +synonym: "ecgonone methyl ester anabolism" EXACT [GOC:TermGenie] +synonym: "ecgonone methyl ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "ecgonone methyl ester formation" EXACT [GOC:TermGenie] +synonym: "ecgonone methyl ester synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009710 ! tropane alkaloid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1901870 ! ecgonone methyl ester metabolic process + +[Term] +id: GO:1901873 +name: regulation of post-translational protein modification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] +synonym: "regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "regulation of PTM" EXACT [GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0043687 ! post-translational protein modification + +[Term] +id: GO:1901874 +name: negative regulation of post-translational protein modification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] +synonym: "down regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "down regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "down regulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "down regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "down regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "down regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "down regulation of PTM" EXACT [GOC:TermGenie] +synonym: "down-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of PTM" EXACT [GOC:TermGenie] +synonym: "downregulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "downregulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "downregulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "downregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "downregulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "downregulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "downregulation of PTM" EXACT [GOC:TermGenie] +synonym: "inhibition of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "inhibition of post-translational modification" EXACT [GOC:TermGenie] +synonym: "inhibition of post-translational protein modification" NARROW [GOC:TermGenie] +synonym: "inhibition of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "inhibition of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "inhibition of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "inhibition of PTM" EXACT [GOC:TermGenie] +synonym: "negative regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of PTM" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1901873 ! regulation of post-translational protein modification +relationship: negatively_regulates GO:0043687 ! post-translational protein modification + +[Term] +id: GO:1901875 +name: positive regulation of post-translational protein modification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of post-translational protein modification." [GOC:TermGenie, GOC:yaf, PMID:21209915] +synonym: "activation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "activation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "activation of post-translational protein modification" NARROW [GOC:TermGenie] +synonym: "activation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "activation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "activation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "activation of PTM" EXACT [GOC:TermGenie] +synonym: "positive regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of PTM" EXACT [GOC:TermGenie] +synonym: "up regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "up regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "up regulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "up regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "up regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "up regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "up regulation of PTM" EXACT [GOC:TermGenie] +synonym: "up-regulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of PTM" EXACT [GOC:TermGenie] +synonym: "upregulation of post-translational amino acid modification" EXACT [GOC:TermGenie] +synonym: "upregulation of post-translational modification" EXACT [GOC:TermGenie] +synonym: "upregulation of post-translational protein modification" EXACT [GOC:TermGenie] +synonym: "upregulation of posttranslational amino acid modification" EXACT [GOC:TermGenie] +synonym: "upregulation of posttranslational modification" EXACT [GOC:TermGenie] +synonym: "upregulation of posttranslational protein modification" EXACT [GOC:TermGenie] +synonym: "upregulation of PTM" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1901873 ! regulation of post-translational protein modification +relationship: positively_regulates GO:0043687 ! post-translational protein modification + +[Term] +id: GO:1901876 +name: regulation of calcium ion binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] +synonym: "regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1901877 +name: negative regulation of calcium ion binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] +synonym: "down regulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "downregulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "inhibition of calcium ion binding" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1901876 ! regulation of calcium ion binding + +[Term] +id: GO:1901878 +name: positive regulation of calcium ion binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion binding." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16432188] +synonym: "activation of calcium ion binding" NARROW [GOC:TermGenie] +synonym: "activation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "up regulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion storage activity" RELATED [GOC:TermGenie] +synonym: "upregulation of calcium ion binding" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion storage activity" RELATED [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1901876 ! regulation of calcium ion binding + +[Term] +id: GO:1901879 +name: regulation of protein depolymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] +synonym: "regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of protein polymer degradation" EXACT [GOC:TermGenie] +is_a: GO:0043244 ! regulation of protein-containing complex disassembly +relationship: regulates GO:0051261 ! protein depolymerization + +[Term] +id: GO:1901880 +name: negative regulation of protein depolymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] +synonym: "down regulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein depolymerization" NARROW [GOC:TermGenie] +synonym: "inhibition of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "inhibition of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein polymer degradation" EXACT [GOC:TermGenie] +is_a: GO:0043242 ! negative regulation of protein-containing complex disassembly +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: negatively_regulates GO:0051261 ! protein depolymerization + +[Term] +id: GO:1901881 +name: positive regulation of protein depolymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein depolymerization." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12032137] +synonym: "activation of protein depolymerization" NARROW [GOC:TermGenie] +synonym: "activation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "activation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "activation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "activation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polymer degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein depolymerization" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polymer breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polymer catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polymer catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polymer degradation" EXACT [GOC:TermGenie] +is_a: GO:0043243 ! positive regulation of protein-containing complex disassembly +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: positively_regulates GO:0051261 ! protein depolymerization + +[Term] +id: GO:1901882 +name: 4-hydroxycoumarin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] +synonym: "4-hydroxycoumarin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009804 ! coumarin metabolic process + +[Term] +id: GO:1901883 +name: 4-hydroxycoumarin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] +synonym: "4-hydroxycoumarin breakdown" EXACT [GOC:TermGenie] +synonym: "4-hydroxycoumarin catabolism" EXACT [GOC:TermGenie] +synonym: "4-hydroxycoumarin degradation" EXACT [GOC:TermGenie] +is_a: GO:0046226 ! coumarin catabolic process +is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process + +[Term] +id: GO:1901884 +name: 4-hydroxycoumarin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 4-hydroxycoumarin." [GOC:TermGenie, pmid:19757094] +synonym: "4-hydroxycoumarin anabolism" EXACT [GOC:TermGenie] +synonym: "4-hydroxycoumarin biosynthesis" EXACT [GOC:TermGenie] +synonym: "4-hydroxycoumarin formation" EXACT [GOC:TermGenie] +synonym: "4-hydroxycoumarin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009805 ! coumarin biosynthetic process +is_a: GO:1901882 ! 4-hydroxycoumarin metabolic process + +[Term] +id: GO:1901885 +name: 2-hydroxybenzoyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] +synonym: "2-hydroxybenzoyl-CoA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006637 ! acyl-CoA metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process + +[Term] +id: GO:1901886 +name: 2-hydroxybenzoyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] +synonym: "2-hydroxybenzoyl-CoA breakdown" EXACT [GOC:TermGenie] +synonym: "2-hydroxybenzoyl-CoA catabolism" EXACT [GOC:TermGenie] +synonym: "2-hydroxybenzoyl-CoA degradation" EXACT [GOC:TermGenie] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process + +[Term] +id: GO:1901887 +name: 2-hydroxybenzoyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-hydroxybenzoyl-CoA." [GOC:TermGenie, pmid:19757094] +synonym: "2-hydroxybenzoyl-CoA anabolism" EXACT [GOC:TermGenie] +synonym: "2-hydroxybenzoyl-CoA biosynthesis" EXACT [GOC:TermGenie] +synonym: "2-hydroxybenzoyl-CoA formation" EXACT [GOC:TermGenie] +synonym: "2-hydroxybenzoyl-CoA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process +is_a: GO:1901885 ! 2-hydroxybenzoyl-CoA metabolic process + +[Term] +id: GO:1901888 +name: regulation of cell junction assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0034329 ! cell junction assembly + +[Term] +id: GO:1901889 +name: negative regulation of cell junction assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] +synonym: "down regulation of cell junction assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell junction assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cell junction assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of cell junction assembly" NARROW [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: negatively_regulates GO:0034329 ! cell junction assembly + +[Term] +id: GO:1901890 +name: positive regulation of cell junction assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell junction assembly." [GOC:TermGenie] +synonym: "activation of cell junction assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of cell junction assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell junction assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of cell junction assembly" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: positively_regulates GO:0034329 ! cell junction assembly + +[Term] +id: GO:1901891 +name: regulation of cell septum assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] +is_a: GO:0032954 ! regulation of cytokinetic process +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0090529 ! cell septum assembly + +[Term] +id: GO:1901892 +name: negative regulation of cell septum assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] +synonym: "down regulation of cell septum assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell septum assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cell septum assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of cell septum assembly" NARROW [GOC:TermGenie] +is_a: GO:0032466 ! negative regulation of cytokinesis +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1901891 ! regulation of cell septum assembly +relationship: negatively_regulates GO:0090529 ! cell septum assembly + +[Term] +id: GO:1901893 +name: positive regulation of cell septum assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell septum assembly." [GOC:TermGenie] +synonym: "activation of cell septum assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of cell septum assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell septum assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of cell septum assembly" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1901891 ! regulation of cell septum assembly +relationship: positively_regulates GO:0090529 ! cell septum assembly + +[Term] +id: GO:1901894 +name: regulation of ATPase-coupled calcium transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +synonym: "regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "regulation of calcium-transporting ATPase activity" EXACT [] +synonym: "regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity + +[Term] +id: GO:1901895 +name: negative regulation of ATPase-coupled calcium transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +synonym: "down regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "down regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "down regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "down regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "down regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "down regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "down regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "down-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "down-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "down-regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "down-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "down-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "down-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "downregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "downregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "downregulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "downregulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "downregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "downregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "downregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "inhibition of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium pump" BROAD [GOC:TermGenie] +synonym: "inhibition of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium-transporting ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "inhibition of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "negative regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "negative regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium-transporting ATPase activity" EXACT [] +synonym: "negative regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "negative regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "negative regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity + +[Term] +id: GO:1901896 +name: positive regulation of ATPase-coupled calcium transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an ATPase-coupled calcium transmembrane transporter activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +synonym: "activation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "activation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "activation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "activation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "activation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "activation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "activation of calcium pump" BROAD [GOC:TermGenie] +synonym: "activation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "activation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of calcium-transporting ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "activation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "activation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "positive regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "positive regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium-transporting ATPase activity" EXACT [] +synonym: "positive regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "positive regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "positive regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "up regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "up regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "up regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "up regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "up regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "up-regulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "up-regulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "up-regulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "up-regulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "up-regulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "up-regulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +synonym: "upregulation of ATP phosphohydrolase (Ca2+-transporting)" EXACT [GOC:TermGenie] +synonym: "upregulation of Ca(2+)-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Ca2+-pumping ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Ca2+-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ABC transporter" NARROW [GOC:TermGenie] +synonym: "upregulation of calcium efflux ATPase" NARROW [GOC:TermGenie] +synonym: "upregulation of calcium pump" BROAD [GOC:TermGenie] +synonym: "upregulation of calcium transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-translocating P-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of calcium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of plasma membrane Ca-ATPase" NARROW [GOC:TermGenie] +synonym: "upregulation of sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [GOC:TermGenie] +synonym: "upregulation of sarcoplasmic reticulum ATPase" NARROW [GOC:TermGenie] +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:1901894 ! regulation of ATPase-coupled calcium transmembrane transporter activity + +[Term] +id: GO:1901897 +name: regulation of relaxation of cardiac muscle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +is_a: GO:1901077 ! regulation of relaxation of muscle +relationship: regulates GO:0055119 ! relaxation of cardiac muscle + +[Term] +id: GO:1901898 +name: negative regulation of relaxation of cardiac muscle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +synonym: "down regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +synonym: "down-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +synonym: "downregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +synonym: "inhibition of relaxation of cardiac muscle" NARROW [GOC:TermGenie] +is_a: GO:1901078 ! negative regulation of relaxation of muscle +is_a: GO:1901897 ! regulation of relaxation of cardiac muscle +relationship: negatively_regulates GO:0055119 ! relaxation of cardiac muscle + +[Term] +id: GO:1901899 +name: positive regulation of relaxation of cardiac muscle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of relaxation of cardiac muscle." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671] +synonym: "activation of relaxation of cardiac muscle" NARROW [GOC:TermGenie] +synonym: "up regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +synonym: "up-regulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +synonym: "upregulation of relaxation of cardiac muscle" EXACT [GOC:TermGenie] +is_a: GO:1901079 ! positive regulation of relaxation of muscle +is_a: GO:1901897 ! regulation of relaxation of cardiac muscle +relationship: positively_regulates GO:0055119 ! relaxation of cardiac muscle + +[Term] +id: GO:1901900 +name: regulation of protein localization to cell division site +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell division site." [GOC:dph, GOC:TermGenie, PMID:22573892] +synonym: "regulation of protein localisation to cell division site" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0072741 ! protein localization to cell division site + +[Term] +id: GO:1901901 +name: regulation of protein localization to cell division site involved in cytokinesis +namespace: biological_process +def: "Any regulation of protein localization to cell division site that is involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892] +synonym: "regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:1901900 ! regulation of protein localization to cell division site +relationship: part_of GO:0000910 ! cytokinesis + +[Term] +id: GO:1901902 +name: tyrocidine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938] +synonym: "tyrocidine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1901903 +name: tyrocidine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938] +synonym: "tyrocidine breakdown" EXACT [GOC:TermGenie] +synonym: "tyrocidine catabolism" EXACT [GOC:TermGenie] +synonym: "tyrocidine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009056 ! catabolic process +is_a: GO:1901902 ! tyrocidine metabolic process + +[Term] +id: GO:1901904 +name: tyrocidine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tyrocidine." [GOC:TermGenie, GOC:yaf, PMID:9352938, UniPathway:UPA00180] +synonym: "tyrocidine anabolism" EXACT [GOC:TermGenie] +synonym: "tyrocidine biosynthesis" EXACT [GOC:TermGenie] +synonym: "tyrocidine formation" EXACT [GOC:TermGenie] +synonym: "tyrocidine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:1901902 ! tyrocidine metabolic process + +[Term] +id: GO:1901905 +name: response to tamsulosin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tamsulosin stimulus." [GOC:TermGenie] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0014075 ! response to amine +is_a: GO:0045472 ! response to ether + +[Term] +id: GO:1901906 +name: diadenosine pentaphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752] +synonym: "diadenosine pentaphosphate metabolism" EXACT [GOC:pr] +synonym: "diadenosyl pentaphosphate metabolic process" EXACT [GOC:pr] +synonym: "diadenosyl pentaphosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:1901907 +name: diadenosine pentaphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate." [GOC:TermGenie, PMID:10090752] +synonym: "diadenosine pentaphosphate catabolism" EXACT [GOC:pr] +synonym: "diadenosyl pentaphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "diadenosyl pentaphosphate catabolic process" EXACT [GOC:pr] +synonym: "diadenosyl pentaphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "diadenosyl pentaphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:1901906 ! diadenosine pentaphosphate metabolic process + +[Term] +id: GO:1901908 +name: diadenosine hexaphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752] +synonym: "diadenosine hexaphosphate metabolism" EXACT [GOC:pr] +synonym: "diadenosyl hexaphosphate metabolic process" EXACT [GOC:pr] +synonym: "diadenosyl hexaphosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0015959 ! diadenosine polyphosphate metabolic process + +[Term] +id: GO:1901909 +name: diadenosine hexaphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate." [GOC:TermGenie, PMID:10090752] +synonym: "diadenosine hexaphosphate catabolism" EXACT [GOC:pr] +synonym: "diadenosyl hexaphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "diadenosyl hexaphosphate catabolic process" EXACT [GOC:pr] +synonym: "diadenosyl hexaphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "diadenosyl hexaphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0015961 ! diadenosine polyphosphate catabolic process +is_a: GO:1901908 ! diadenosine hexaphosphate metabolic process + +[Term] +id: GO:1901910 +name: adenosine 5'-(hexahydrogen pentaphosphate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752] +synonym: "adenosine 5'-(hexahydrogen pentaphosphate) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009150 ! purine ribonucleotide metabolic process + +[Term] +id: GO:1901911 +name: adenosine 5'-(hexahydrogen pentaphosphate) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate)." [GOC:TermGenie, PMID:10090752] +synonym: "adenosine 5'-(hexahydrogen pentaphosphate) breakdown" EXACT [GOC:TermGenie] +synonym: "adenosine 5'-(hexahydrogen pentaphosphate) catabolism" EXACT [GOC:TermGenie] +synonym: "adenosine 5'-(hexahydrogen pentaphosphate) degradation" EXACT [GOC:TermGenie] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:1901910 ! adenosine 5'-(hexahydrogen pentaphosphate) metabolic process + +[Term] +id: GO:1901913 +name: regulation of capsule organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] +synonym: "regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0045230 ! capsule organization + +[Term] +id: GO:1901914 +name: negative regulation of capsule organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] +synonym: "down regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "down regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "downregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of capsule organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of capsule organization" NARROW [GOC:TermGenie] +synonym: "inhibition of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1901913 ! regulation of capsule organization +relationship: negatively_regulates GO:0045230 ! capsule organization + +[Term] +id: GO:1901915 +name: positive regulation of capsule organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of capsule organization." [GOC:di, GOC:TermGenie] +synonym: "activation of capsule organisation" NARROW [GOC:TermGenie] +synonym: "activation of capsule organization" NARROW [GOC:TermGenie] +synonym: "activation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "up regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of capsule organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of capsule organization" EXACT [GOC:TermGenie] +synonym: "upregulation of capsule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1901913 ! regulation of capsule organization +relationship: positively_regulates GO:0045230 ! capsule organization + +[Term] +id: GO:1901916 +name: obsolete protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis +namespace: molecular_function +def: "OBSOLETE. Any protein kinase activity that is involved in regulation of protein localization to cell division site involved in cytokinesis." [GOC:dph, GOC:TermGenie, PMID:22573892] +comment: This term was obsoleted is that this term represents both a function and a process. +synonym: "protamine kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" NARROW [GOC:TermGenie] +synonym: "protamine kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis" NARROW [GOC:TermGenie] +synonym: "protein kinase activity involved in regulation of protein localisation to cell division site involved in cytokinesis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1901917 +name: regulation of exoribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] +is_a: GO:0060700 ! regulation of ribonuclease activity +is_a: GO:1905777 ! regulation of exonuclease activity + +[Term] +id: GO:1901918 +name: negative regulation of exoribonuclease activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] +synonym: "down regulation of exoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of exoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "downregulation of exoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "inhibition of exoribonuclease activity" NARROW [GOC:TermGenie] +is_a: GO:0060701 ! negative regulation of ribonuclease activity +is_a: GO:1901917 ! regulation of exoribonuclease activity +is_a: GO:1905778 ! negative regulation of exonuclease activity + +[Term] +id: GO:1901919 +name: positive regulation of exoribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exoribonuclease activity." [GOC:TermGenie, PMID:22570495] +synonym: "activation of exoribonuclease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of exoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of exoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "upregulation of exoribonuclease activity" EXACT [GOC:TermGenie] +is_a: GO:1901917 ! regulation of exoribonuclease activity +is_a: GO:1905779 ! positive regulation of exonuclease activity + +[Term] +id: GO:1901920 +name: peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity +namespace: biological_process +def: "Any peptidyl-tyrosine dephosphorylation that is involved in activation of protein kinase activity." [GOC:TermGenie, PMID:1756737] +synonym: "peptidyl-tyrosine dephosphorylation involved in protein kinase activation" RELATED [GOC:TermGenie] +is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation +relationship: part_of GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:1901921 +name: phosphorylation of RNA polymerase II C-terminal domain involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex +namespace: biological_process +def: "Any phosphorylation of RNA polymerase II C-terminal domain that is involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex." [GOC:TermGenie, PMID:10594013] +synonym: "CTD domain phosphorylation of RNA polymerase II involved in recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex" EXACT [GOC:TermGenie] +is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain +relationship: part_of GO:0034402 ! recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex + +[Term] +id: GO:1901922 +name: regulation of sclerotium development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:1990045 ! sclerotium development + +[Term] +id: GO:1901923 +name: negative regulation of sclerotium development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] +synonym: "down regulation of sclerotium development" EXACT [GOC:TermGenie] +synonym: "down-regulation of sclerotium development" EXACT [GOC:TermGenie] +synonym: "downregulation of sclerotium development" EXACT [GOC:TermGenie] +synonym: "inhibition of sclerotium development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901922 ! regulation of sclerotium development +relationship: negatively_regulates GO:1990045 ! sclerotium development + +[Term] +id: GO:1901924 +name: positive regulation of sclerotium development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sclerotium development." [GOC:di, GOC:TermGenie, PMID:21148914] +synonym: "activation of sclerotium development" NARROW [GOC:TermGenie] +synonym: "up regulation of sclerotium development" EXACT [GOC:TermGenie] +synonym: "up-regulation of sclerotium development" EXACT [GOC:TermGenie] +synonym: "upregulation of sclerotium development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1901922 ! regulation of sclerotium development +relationship: positively_regulates GO:1990045 ! sclerotium development + +[Term] +id: GO:1901925 +name: negative regulation of protein import into nucleus during spindle assembly checkpoint +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p)." [GOC:dgf, GOC:TermGenie, PMID:23177738] +synonym: "Kap121p transport inhibitory pathway" RELATED [] +synonym: "KTIP" RELATED [] +synonym: "negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint" EXACT [] +is_a: GO:0072479 ! response to mitotic cell cycle spindle assembly checkpoint signaling + +[Term] +id: GO:1901926 +name: cadinene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cadinene." [GOC:TermGenie, pmid:22867794] +synonym: "cadinene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051761 ! sesquiterpene metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901927 +name: cadinene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cadinene." [GOC:TermGenie, pmid:22867794] +synonym: "cadinene breakdown" EXACT [GOC:TermGenie] +synonym: "cadinene catabolism" EXACT [GOC:TermGenie] +synonym: "cadinene degradation" EXACT [GOC:TermGenie] +is_a: GO:0051763 ! sesquiterpene catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901926 ! cadinene metabolic process + +[Term] +id: GO:1901928 +name: cadinene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cadinene." [GOC:TermGenie, pmid:22867794] +synonym: "cadinene anabolism" EXACT [GOC:TermGenie] +synonym: "cadinene biosynthesis" EXACT [GOC:TermGenie] +synonym: "cadinene formation" EXACT [GOC:TermGenie] +synonym: "cadinene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901926 ! cadinene metabolic process + +[Term] +id: GO:1901929 +name: alpha-copaene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving alpha-copaene." [GOC:TermGenie, pmid:22867794] +synonym: "alpha-copaene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:1901930 +name: alpha-copaene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of alpha-copaene." [GOC:TermGenie, pmid:22867794] +synonym: "alpha-copaene breakdown" EXACT [GOC:TermGenie] +synonym: "alpha-copaene catabolism" EXACT [GOC:TermGenie] +synonym: "alpha-copaene degradation" EXACT [GOC:TermGenie] +is_a: GO:0051763 ! sesquiterpene catabolic process +is_a: GO:1901929 ! alpha-copaene metabolic process + +[Term] +id: GO:1901931 +name: alpha-copaene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of alpha-copaene." [GOC:TermGenie, pmid:22867794] +synonym: "alpha-copaene anabolism" EXACT [GOC:TermGenie] +synonym: "alpha-copaene biosynthesis" EXACT [GOC:TermGenie] +synonym: "alpha-copaene formation" EXACT [GOC:TermGenie] +synonym: "alpha-copaene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1901929 ! alpha-copaene metabolic process + +[Term] +id: GO:1901932 +name: bicyclogermacrene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bicyclogermacrene." [GOC:TermGenie, pmid:22867794] +synonym: "bicyclogermacrene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051761 ! sesquiterpene metabolic process + +[Term] +id: GO:1901933 +name: bicyclogermacrene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of bicyclogermacrene." [GOC:TermGenie, pmid:22867794] +synonym: "bicyclogermacrene breakdown" EXACT [GOC:TermGenie] +synonym: "bicyclogermacrene catabolism" EXACT [GOC:TermGenie] +synonym: "bicyclogermacrene degradation" EXACT [GOC:TermGenie] +is_a: GO:0051763 ! sesquiterpene catabolic process +is_a: GO:1901932 ! bicyclogermacrene metabolic process + +[Term] +id: GO:1901934 +name: bicyclogermacrene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of bicyclogermacrene." [GOC:TermGenie, pmid:22867794] +synonym: "bicyclogermacrene anabolism" EXACT [GOC:TermGenie] +synonym: "bicyclogermacrene biosynthesis" EXACT [GOC:TermGenie] +synonym: "bicyclogermacrene formation" EXACT [GOC:TermGenie] +synonym: "bicyclogermacrene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1901932 ! bicyclogermacrene metabolic process + +[Term] +id: GO:1901935 +name: beta-caryophyllene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving beta-caryophyllene." [GOC:TermGenie, pmid:22867794] +synonym: "beta-caryophyllene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051761 ! sesquiterpene metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901936 +name: beta-caryophyllene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of beta-caryophyllene." [GOC:TermGenie, pmid:22867794] +synonym: "beta-caryophyllene breakdown" EXACT [GOC:TermGenie] +synonym: "beta-caryophyllene catabolism" EXACT [GOC:TermGenie] +synonym: "beta-caryophyllene degradation" EXACT [GOC:TermGenie] +is_a: GO:0051763 ! sesquiterpene catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901935 ! beta-caryophyllene metabolic process + +[Term] +id: GO:1901937 +name: beta-caryophyllene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of beta-caryophyllene." [GOC:TermGenie, pmid:22867794] +synonym: "beta-caryophyllene anabolism" EXACT [GOC:TermGenie] +synonym: "beta-caryophyllene biosynthesis" EXACT [GOC:TermGenie] +synonym: "beta-caryophyllene formation" EXACT [GOC:TermGenie] +synonym: "beta-caryophyllene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901935 ! beta-caryophyllene metabolic process + +[Term] +id: GO:1901938 +name: (-)-exo-alpha-bergamotene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] +synonym: "(-)-exo-alpha-bergamotene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051761 ! sesquiterpene metabolic process +is_a: GO:1900673 ! olefin metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901939 +name: (-)-exo-alpha-bergamotene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] +synonym: "(-)-exo-alpha-bergamotene breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-exo-alpha-bergamotene catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-exo-alpha-bergamotene degradation" EXACT [GOC:TermGenie] +is_a: GO:0051763 ! sesquiterpene catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process + +[Term] +id: GO:1901940 +name: (-)-exo-alpha-bergamotene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-exo-alpha-bergamotene." [GOC:TermGenie, pmid:22867794] +synonym: "(-)-exo-alpha-bergamotene anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-exo-alpha-bergamotene biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-exo-alpha-bergamotene formation" EXACT [GOC:TermGenie] +synonym: "(-)-exo-alpha-bergamotene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051762 ! sesquiterpene biosynthetic process +is_a: GO:1900674 ! olefin biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901938 ! (-)-exo-alpha-bergamotene metabolic process + +[Term] +id: GO:1901941 +name: (+)-epi-alpha-bisabolol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] +synonym: "(+)-epi-alpha-bisabolol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006714 ! sesquiterpenoid metabolic process + +[Term] +id: GO:1901942 +name: (+)-epi-alpha-bisabolol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] +synonym: "(+)-epi-alpha-bisabolol breakdown" EXACT [GOC:TermGenie] +synonym: "(+)-epi-alpha-bisabolol catabolism" EXACT [GOC:TermGenie] +synonym: "(+)-epi-alpha-bisabolol degradation" EXACT [GOC:TermGenie] +is_a: GO:0016107 ! sesquiterpenoid catabolic process +is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process + +[Term] +id: GO:1901943 +name: (+)-epi-alpha-bisabolol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-epi-alpha-bisabolol." [GOC:TermGenie, pmid:22867794] +synonym: "(+)-epi-alpha-bisabolol anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-epi-alpha-bisabolol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-epi-alpha-bisabolol formation" EXACT [GOC:TermGenie] +synonym: "(+)-epi-alpha-bisabolol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016106 ! sesquiterpenoid biosynthetic process +is_a: GO:1901941 ! (+)-epi-alpha-bisabolol metabolic process + +[Term] +id: GO:1901944 +name: miltiradiene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving miltiradiene." [GOC:TermGenie, pmid:22027823] +synonym: "miltiradiene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042214 ! terpene metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901945 +name: miltiradiene catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of miltiradiene." [GOC:TermGenie, pmid:22027823] +synonym: "miltiradiene breakdown" EXACT [GOC:TermGenie] +synonym: "miltiradiene catabolism" EXACT [GOC:TermGenie] +synonym: "miltiradiene degradation" EXACT [GOC:TermGenie] +is_a: GO:0046247 ! terpene catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901944 ! miltiradiene metabolic process + +[Term] +id: GO:1901946 +name: miltiradiene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of miltiradiene." [GOC:TermGenie, pmid:22027823] +synonym: "miltiradiene anabolism" EXACT [GOC:TermGenie] +synonym: "miltiradiene biosynthesis" EXACT [GOC:TermGenie] +synonym: "miltiradiene formation" EXACT [GOC:TermGenie] +synonym: "miltiradiene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901944 ! miltiradiene metabolic process + +[Term] +id: GO:1901947 +name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1901948 +name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0016103 ! diterpenoid catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process + +[Term] +id: GO:1901949 +name: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate." [GOC:TermGenie, pmid:22027823] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate formation" EXACT [GOC:TermGenie] +synonym: "5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901947 ! 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate metabolic process + +[Term] +id: GO:1901950 +name: dense core granule transport +namespace: biological_process +def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451] +comment: goslim_synapse +synonym: "dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0032253 ! dense core granule localization +is_a: GO:0051650 ! establishment of vesicle localization + +[Term] +id: GO:1901951 +name: regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +is_a: GO:1904809 ! regulation of dense core granule transport +relationship: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport + +[Term] +id: GO:1901952 +name: negative regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie] +is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule +is_a: GO:1901951 ! regulation of anterograde dense core granule transport +is_a: GO:1904810 ! negative regulation of dense core granule transport +relationship: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport + +[Term] +id: GO:1901953 +name: positive regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule +is_a: GO:1901951 ! regulation of anterograde dense core granule transport +is_a: GO:1904811 ! positive regulation of dense core granule transport +relationship: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport + +[Term] +id: GO:1901954 +name: regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +is_a: GO:1904809 ! regulation of dense core granule transport +is_a: GO:2001017 ! regulation of retrograde axon cargo transport +relationship: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport + +[Term] +id: GO:1901955 +name: negative regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie] +is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule +is_a: GO:1901954 ! regulation of retrograde dense core granule transport +is_a: GO:1904810 ! negative regulation of dense core granule transport +is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport +relationship: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport + +[Term] +id: GO:1901956 +name: positive regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie] +synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule +is_a: GO:1901954 ! regulation of retrograde dense core granule transport +is_a: GO:1904811 ! positive regulation of dense core granule transport +is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport +relationship: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport + +[Term] +id: GO:1901957 +name: regulation of cutin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] +synonym: "regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "regulation of cutin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +relationship: regulates GO:0010143 ! cutin biosynthetic process + +[Term] +id: GO:1901958 +name: negative regulation of cutin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] +synonym: "down regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cutin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cutin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of cutin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:1901957 ! regulation of cutin biosynthetic process +relationship: negatively_regulates GO:0010143 ! cutin biosynthetic process + +[Term] +id: GO:1901959 +name: positive regulation of cutin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cutin biosynthetic process." [GOC:tb, GOC:TermGenie, PMID:23243127] +synonym: "activation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of cutin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of cutin formation" EXACT [GOC:TermGenie] +synonym: "activation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cutin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cutin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of cutin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cutin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cutin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of cutin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:1901957 ! regulation of cutin biosynthetic process +relationship: positively_regulates GO:0010143 ! cutin biosynthetic process + +[Term] +id: GO:1901960 +name: isobutanol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870] +synonym: "isobutanol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0034308 ! primary alcohol metabolic process + +[Term] +id: GO:1901961 +name: isobutanol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isobutanol." [GOC:mengo_curators, GOC:TermGenie, PMID:22224870] +synonym: "isobutanol anabolism" EXACT [GOC:TermGenie] +synonym: "isobutanol biosynthesis" EXACT [GOC:TermGenie] +synonym: "isobutanol formation" EXACT [GOC:TermGenie] +synonym: "isobutanol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:1901960 ! isobutanol metabolic process + +[Term] +id: GO:1901962 +name: S-adenosyl-L-methionine transmembrane transport +namespace: biological_process +def: "The directed movement of S-adenosyl-L-methionine across a membrane." [GOC:TermGenie, PMID:10497160] +synonym: "S-adenosylmethionine transmembrane transport" EXACT [] +synonym: "SAM transmembrane transport" EXACT [] +is_a: GO:0015805 ! S-adenosyl-L-methionine transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1901963 +name: regulation of cell proliferation involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] +is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis +relationship: regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis + +[Term] +id: GO:1901964 +name: positive regulation of cell proliferation involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_heart, GOC:TermGenie, PMID:21419760] +synonym: "activation of cell proliferation involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cell proliferation involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:1901963 ! regulation of cell proliferation involved in outflow tract morphogenesis +is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis +relationship: positively_regulates GO:0061325 ! cell proliferation involved in outflow tract morphogenesis + +[Term] +id: GO:1901965 +name: endoplasmic reticulum to chloroplast transport +namespace: biological_process +def: "The directed movement of substances from endoplasmic reticulum to chloroplast." [GOC:TermGenie, PMID:18689504] +synonym: "ER to chloroplast transport" EXACT [GOC:TermGenie] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:1901966 +name: regulation of cellular response to iron ion starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0010106 ! cellular response to iron ion starvation + +[Term] +id: GO:1901967 +name: negative regulation of cellular response to iron ion starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to iron ion starvation." [GOC:TermGenie, PMID:23115244] +synonym: "down regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to iron ion starvation" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to iron ion starvation" NARROW [GOC:TermGenie] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:1901966 ! regulation of cellular response to iron ion starvation +relationship: negatively_regulates GO:0010106 ! cellular response to iron ion starvation + +[Term] +id: GO:1901968 +name: regulation of polynucleotide 3'-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050] +synonym: "regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:1901969 +name: positive regulation of polynucleotide 3'-phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity." [GOC:TermGenie, PMID:23316050] +synonym: "activation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "activation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "activation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "activation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "activation of polynucleotide 3'-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 2'(3')-polynucleotidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5'-polynucleotidekinase 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleate 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polynucleotide 3'-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polynucleotide 3'-phosphohydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:1901968 ! regulation of polynucleotide 3'-phosphatase activity + +[Term] +id: GO:1901970 +name: positive regulation of mitotic sister chromatid separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation." [GOC:TermGenie, PMID:1846086] +synonym: "activation of chromosome separation during mitosis" RELATED [GOC:TermGenie] +synonym: "activation of mitotic chromosome separation" RELATED [GOC:TermGenie] +synonym: "activation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] +synonym: "activation of mitotic sister chromatid separation" NARROW [GOC:TermGenie] +synonym: "activation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] +synonym: "positive regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] +synonym: "up regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] +synonym: "up regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] +synonym: "up regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] +synonym: "up-regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] +synonym: "upregulation of mitotic chromosome separation" RELATED [GOC:TermGenie] +synonym: "upregulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] +synonym: "upregulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] +is_a: GO:0010965 ! regulation of mitotic sister chromatid separation +is_a: GO:1905820 ! positive regulation of chromosome separation +relationship: positively_regulates GO:0051306 ! mitotic sister chromatid separation + +[Term] +id: GO:1901971 +name: regulation of DNA-5-methylcytosine glycosylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050] +is_a: GO:1902544 ! regulation of DNA N-glycosylase activity + +[Term] +id: GO:1901972 +name: positive regulation of DNA-5-methylcytosine glycosylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-5-methylcytosine glycosylase activity." [GOC:TermGenie, PMID:23316050] +synonym: "activation of DNA-5-methylcytosine glycosylase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA-5-methylcytosine glycosylase activity" EXACT [GOC:TermGenie] +is_a: GO:1901971 ! regulation of DNA-5-methylcytosine glycosylase activity +is_a: GO:1902546 ! positive regulation of DNA N-glycosylase activity + +[Term] +id: GO:1901973 +name: proline binding +namespace: molecular_function +def: "Binding to proline." [GOC:pm, GOC:TermGenie, PMID:7730362] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1901974 +name: glycerate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of glycerate from one side of a membrane to the other." [GOC:TermGenie, pmid:23382251] +is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity +is_a: GO:0015144 ! carbohydrate transmembrane transporter activity +is_a: GO:0042879 ! aldonate transmembrane transporter activity + +[Term] +id: GO:1901975 +name: glycerate transmembrane transport +namespace: biological_process +def: "The process in which glycerate is transported across a membrane." [GOC:TermGenie, pmid:23382251] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0042873 ! aldonate transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1901976 +name: regulation of cell cycle checkpoint +namespace: biological_process +alt_id: GO:2001047 +def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). +subset: gocheck_do_not_manually_annotate +synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol] +synonym: "regulation of G1/S transition checkpoint" RELATED [] +is_a: GO:1901987 ! regulation of cell cycle phase transition +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0000075 ! cell cycle checkpoint signaling + +[Term] +id: GO:1901977 +name: negative regulation of cell cycle checkpoint +namespace: biological_process +alt_id: GO:2001048 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). +subset: gocheck_do_not_manually_annotate +synonym: "down regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "inhibition of cell cycle checkpoint" NARROW [GOC:TermGenie] +synonym: "negative regulation of G1/S checkpoint" RELATED [GOC:obol] +synonym: "negative regulation of G1/S transition checkpoint" RELATED [] +is_a: GO:1901976 ! regulation of cell cycle checkpoint +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +relationship: negatively_regulates GO:0000075 ! cell cycle checkpoint signaling + +[Term] +id: GO:1901978 +name: positive regulation of cell cycle checkpoint +namespace: biological_process +alt_id: GO:2001052 +def: "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] +synonym: "activation of cell cycle checkpoint" NARROW [GOC:TermGenie] +synonym: "positive regulation of G1/S checkpoint" RELATED [GOC:obol] +synonym: "positive regulation of G1/S transition checkpoint" RELATED [] +synonym: "up regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1901976 ! regulation of cell cycle checkpoint +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +relationship: positively_regulates GO:0000075 ! cell cycle checkpoint signaling + +[Term] +id: GO:1901979 +name: regulation of inward rectifier potassium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501] +synonym: "regulation of Kir channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1901980 +name: positive regulation of inward rectifier potassium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity." [GOC:TermGenie, PMID:23449501] +synonym: "activation of inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Kir channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity +is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity + +[Term] +id: GO:1901981 +name: phosphatidylinositol phosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol phosphate." [GOC:TermGenie, PMID:23445487] +is_a: GO:0035091 ! phosphatidylinositol binding + +[Term] +id: GO:1901982 +name: maltose binding +namespace: molecular_function +def: "Binding to maltose." [GOC:TermGenie, PMID:21566157] +is_a: GO:0048030 ! disaccharide binding + +[Term] +id: GO:1901983 +name: regulation of protein acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] +synonym: "regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0006473 ! protein acetylation + +[Term] +id: GO:1901984 +name: negative regulation of protein acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] +synonym: "down regulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein acetylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein amino acid acetylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1901983 ! regulation of protein acetylation +relationship: negatively_regulates GO:0006473 ! protein acetylation + +[Term] +id: GO:1901985 +name: positive regulation of protein acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein acetylation." [GOC:TermGenie, PMID:22117195] +synonym: "activation of protein acetylation" NARROW [GOC:TermGenie] +synonym: "activation of protein amino acid acetylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein amino acid acetylation" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1901983 ! regulation of protein acetylation +relationship: positively_regulates GO:0006473 ! protein acetylation + +[Term] +id: GO:1901986 +name: response to ketamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketamine stimulus." [GOC:TermGenie, PMID:11251190] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1901987 +name: regulation of cell cycle phase transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "cell cycle control" EXACT [GOC:vw] +synonym: "regulation of cell cycle transition" EXACT [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:1901988 +name: negative regulation of cell cycle phase transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "down regulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "down regulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "inhibition of cell cycle phase transition" NARROW [GOC:TermGenie] +synonym: "inhibition of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell cycle transition" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: negatively_regulates GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:1901989 +name: positive regulation of cell cycle phase transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "activation of cell cycle phase transition" NARROW [GOC:TermGenie] +synonym: "activation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "up regulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "up regulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle transition" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle transition" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: positively_regulates GO:0044770 ! cell cycle phase transition + +[Term] +id: GO:1901990 +name: regulation of mitotic cell cycle phase transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "mitotic cell cycle control" EXACT [GOC:vw] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: regulates GO:0044772 ! mitotic cell cycle phase transition + +[Term] +id: GO:1901991 +name: negative regulation of mitotic cell cycle phase transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "down regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +is_a: GO:1901988 ! negative regulation of cell cycle phase transition +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +relationship: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition + +[Term] +id: GO:1901992 +name: positive regulation of mitotic cell cycle phase transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "activation of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] +synonym: "up regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +relationship: positively_regulates GO:0044772 ! mitotic cell cycle phase transition + +[Term] +id: GO:1901993 +name: regulation of meiotic cell cycle phase transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "meiotic cell cycle control" EXACT [GOC:vw] +synonym: "regulation of cell cycle transition" BROAD [GOC:TermGenie] +is_a: GO:1901987 ! regulation of cell cycle phase transition +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0044771 ! meiotic cell cycle phase transition + +[Term] +id: GO:1901994 +name: negative regulation of meiotic cell cycle phase transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "down regulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "down regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "down-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "downregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "inhibition of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "inhibition of meiotic cell cycle phase transition" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell cycle transition" BROAD [GOC:TermGenie] +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +is_a: GO:1901988 ! negative regulation of cell cycle phase transition +is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition +relationship: negatively_regulates GO:0044771 ! meiotic cell cycle phase transition + +[Term] +id: GO:1901995 +name: positive regulation of meiotic cell cycle phase transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] +synonym: "activation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "activation of meiotic cell cycle phase transition" NARROW [GOC:TermGenie] +synonym: "positive regulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "up regulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "up regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "up-regulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle transition" BROAD [GOC:TermGenie] +synonym: "upregulation of meiotic cell cycle phase transition" EXACT [GOC:TermGenie] +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition +relationship: positively_regulates GO:0044771 ! meiotic cell cycle phase transition + +[Term] +id: GO:1901996 +name: regulation of indoleacetic acid biosynthetic process via tryptophan +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040] +synonym: "regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +is_a: GO:0010600 ! regulation of auxin biosynthetic process +is_a: GO:0090357 ! regulation of tryptophan metabolic process +relationship: regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan + +[Term] +id: GO:1901997 +name: negative regulation of indoleacetic acid biosynthetic process via tryptophan +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of indoleacetic acid biosynthetic process via tryptophan." [GOC:TermGenie, PMID:23377040] +synonym: "down regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "down regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "down regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "down regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "down regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of indoleacetic acid biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +synonym: "inhibition of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "inhibition of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "inhibition of indoleacetic acid biosynthetic process via tryptophan" NARROW [GOC:TermGenie] +synonym: "inhibition of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "inhibition of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +synonym: "negative regulation of IAA biosynthetic process via tryptophan" EXACT [GOC:TermGenie] +synonym: "negative regulation of indoleacetic acid anabolism via tryptophan" EXACT [GOC:TermGenie] +synonym: "negative regulation of indoleacetic acid formation via tryptophan" EXACT [GOC:TermGenie] +synonym: "negative regulation of indoleacetic acid synthesis via tryptophan" EXACT [GOC:TermGenie] +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:0090356 ! negative regulation of auxin metabolic process +is_a: GO:1901996 ! regulation of indoleacetic acid biosynthetic process via tryptophan +relationship: negatively_regulates GO:0009848 ! indoleacetic acid biosynthetic process via tryptophan + +[Term] +id: GO:1901998 +name: toxin transport +namespace: biological_process +def: "The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:17118486] +is_a: GO:0006810 ! transport + +[Term] +id: GO:1901999 +name: homogentisate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving homogentisate." [GOC:TermGenie, PMID:22980205] +synonym: "homogentisate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process + +[Term] +id: GO:1902000 +name: homogentisate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of homogentisate." [GOC:TermGenie, PMID:22980205] +synonym: "homogentisate breakdown" EXACT [GOC:TermGenie] +synonym: "homogentisate catabolism" EXACT [GOC:TermGenie] +synonym: "homogentisate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901999 ! homogentisate metabolic process + +[Term] +id: GO:1902001 +name: fatty acid transmembrane transport +namespace: biological_process +def: "The process in which a fatty acid is transported across a membrane." [GOC:rb, GOC:TermGenie, PMID:9395310] +is_a: GO:0015908 ! fatty acid transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1902002 +name: obsolete protein phosphorylation involved in cellular protein catabolic process +namespace: biological_process +def: "OBSOLETE. Any protein phosphorylation that is involved in cellular protein catabolic process." [GOC:rb, GOC:TermGenie, PMID:21098119, PMID:21993622, PMID:23264631] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "protein amino acid phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "protein amino acid phosphorylation involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "protein amino acid phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "protein amino acid phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "protein phosphorylation involved in cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "protein phosphorylation involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "protein phosphorylation involved in cellular protein degradation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902003 +name: regulation of amyloid-beta formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871] +synonym: "regulation of beta-amyloid formation" EXACT [] +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process +relationship: regulates GO:0034205 ! amyloid-beta formation + +[Term] +id: GO:1902004 +name: positive regulation of amyloid-beta formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amyloid-beta formation." [GOC:dph, GOC:TermGenie, PMID:17098871] +synonym: "activation of beta-amyloid formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-amyloid formation" EXACT [] +synonym: "up regulation of beta-amyloid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-amyloid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-amyloid formation" EXACT [GOC:TermGenie] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:1902003 ! regulation of amyloid-beta formation +is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process +relationship: positively_regulates GO:0034205 ! amyloid-beta formation + +[Term] +id: GO:1902005 +name: regulation of proline biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322] +synonym: "regulation of proline anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of proline formation" EXACT [GOC:TermGenie] +synonym: "regulation of proline synthesis" EXACT [GOC:TermGenie] +is_a: GO:2000214 ! regulation of proline metabolic process +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0006561 ! proline biosynthetic process + +[Term] +id: GO:1902006 +name: negative regulation of proline biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline biosynthetic process." [GOC:TermGenie, PMID:23415322] +synonym: "down regulation of proline anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of proline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of proline formation" EXACT [GOC:TermGenie] +synonym: "down regulation of proline synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of proline anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of proline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of proline formation" EXACT [GOC:TermGenie] +synonym: "downregulation of proline synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of proline anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of proline biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of proline formation" EXACT [GOC:TermGenie] +synonym: "inhibition of proline synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of proline anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of proline biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of proline formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of proline synthesis" EXACT [GOC:TermGenie] +is_a: GO:1902005 ! regulation of proline biosynthetic process +is_a: GO:2000215 ! negative regulation of proline metabolic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0006561 ! proline biosynthetic process + +[Term] +id: GO:1902007 +name: regulation of toxin transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:1901998 ! toxin transport + +[Term] +id: GO:1902008 +name: negative regulation of toxin transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] +synonym: "down regulation of toxin transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of toxin transport" EXACT [GOC:TermGenie] +synonym: "downregulation of toxin transport" EXACT [GOC:TermGenie] +synonym: "inhibition of toxin transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1902007 ! regulation of toxin transport +relationship: negatively_regulates GO:1901998 ! toxin transport + +[Term] +id: GO:1902009 +name: positive regulation of toxin transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of toxin transport." [GOC:dph, GOC:TermGenie, PMID:22792315] +synonym: "activation of toxin transport" NARROW [GOC:TermGenie] +synonym: "up regulation of toxin transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of toxin transport" EXACT [GOC:TermGenie] +synonym: "upregulation of toxin transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1902007 ! regulation of toxin transport +relationship: positively_regulates GO:1901998 ! toxin transport + +[Term] +id: GO:1902010 +name: negative regulation of translation in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:dph, GOC:TermGenie, PMID:10882126] +synonym: "down regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "down regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "downregulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "downregulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "inhibition of protein biosynthetic process involved in ER stress response" NARROW [GOC:TermGenie] +synonym: "inhibition of protein biosynthetic process involved in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "inhibition of protein biosynthetic process involved in response to ER stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein anabolism involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein anabolism involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein anabolism involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthesis involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthesis involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthetic process involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthetic process involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein biosynthetic process involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein formation involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein formation involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein formation involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein synthesis involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein synthesis involved in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein synthesis involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of translation involved in ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of translation involved in response to ER stress" EXACT [GOC:TermGenie] +synonym: "protein biosynthesis inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie] +synonym: "protein biosynthesis inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "protein biosynthesis inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie] +synonym: "protein biosynthetic process inhibitor activity involved in ER stress response" RELATED [GOC:TermGenie] +synonym: "protein biosynthetic process inhibitor activity involved in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "protein biosynthetic process inhibitor activity involved in response to ER stress" RELATED [GOC:TermGenie] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0036490 ! regulation of translation in response to endoplasmic reticulum stress + +[Term] +id: GO:1902011 +name: poly(ribitol phosphate) teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790] +synonym: "poly(ribitol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046374 ! teichoic acid metabolic process + +[Term] +id: GO:1902012 +name: poly(ribitol phosphate) teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(ribitol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00790] +synonym: "poly(ribitol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] +synonym: "poly(ribitol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(ribitol phosphate) teichoic acid formation" EXACT [GOC:TermGenie] +synonym: "poly(ribitol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019350 ! teichoic acid biosynthetic process +is_a: GO:1902011 ! poly(ribitol phosphate) teichoic acid metabolic process + +[Term] +id: GO:1902013 +name: poly(glycerol phosphate) teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827] +synonym: "poly(glycerol phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046374 ! teichoic acid metabolic process + +[Term] +id: GO:1902014 +name: poly(glycerol phosphate) teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(glycerol phosphate) teichoic acid." [GOC:TermGenie, PMID:11882717, UniPathway:UPA00827] +synonym: "poly(glycerol phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] +synonym: "poly(glycerol phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(glycerol phosphate) teichoic acid formation" EXACT [GOC:TermGenie] +synonym: "poly(glycerol phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019350 ! teichoic acid biosynthetic process +is_a: GO:1902013 ! poly(glycerol phosphate) teichoic acid metabolic process + +[Term] +id: GO:1902015 +name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828] +synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [GOC:TermGenie] +synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process" EXACT [] +synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolism" EXACT [] +is_a: GO:0046374 ! teichoic acid metabolic process + +[Term] +id: GO:1902016 +name: poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid." [GOC:TermGenie, PMID:16735734, UniPathway:UPA00789, UniPathway:UPA00828] +synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid anabolism" EXACT [GOC:TermGenie] +synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid formation" EXACT [GOC:TermGenie] +synonym: "poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid synthesis" EXACT [GOC:TermGenie] +synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthesis" EXACT [] +synonym: "poly(glucosyl N-acetylgalactosamine 1-phosphate) teichoic acid biosynthetic process" EXACT [] +is_a: GO:0019350 ! teichoic acid biosynthetic process +is_a: GO:1902015 ! poly(glucopyranosyl N-acetylgalactosamine 1-phosphate) teichoic acid metabolic process + +[Term] +id: GO:1902017 +name: regulation of cilium assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] +synonym: "regulation of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of cilium biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0060271 ! cilium assembly + +[Term] +id: GO:1902018 +name: negative regulation of cilium assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly." [GOC:cilia, GOC:dph, GOC:TermGenie, PMID:17719545] +synonym: "down regulation of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cilium assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cilium assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cilium assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cilium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of ciliogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cilium biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +is_a: GO:1902017 ! regulation of cilium assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0060271 ! cilium assembly + +[Term] +id: GO:1902019 +name: regulation of cilium-dependent cell motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] +synonym: "regulation of ciliary cell motility" RELATED [] +synonym: "regulation of cilium cell motility" EXACT [] +is_a: GO:2000145 ! regulation of cell motility +relationship: regulates GO:0060285 ! cilium-dependent cell motility + +[Term] +id: GO:1902020 +name: negative regulation of cilium-dependent cell motility +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] +synonym: "down regulation of ciliary cell motility" EXACT [GOC:TermGenie] +synonym: "down-regulation of ciliary cell motility" EXACT [GOC:TermGenie] +synonym: "downregulation of ciliary cell motility" EXACT [GOC:TermGenie] +synonym: "inhibition of ciliary cell motility" NARROW [GOC:TermGenie] +synonym: "negative regulation of ciliary cell motility" RELATED [] +synonym: "negative regulation of cilium cell motility" EXACT [] +is_a: GO:1902019 ! regulation of cilium-dependent cell motility +is_a: GO:2000146 ! negative regulation of cell motility +relationship: negatively_regulates GO:0060285 ! cilium-dependent cell motility + +[Term] +id: GO:1902021 +name: regulation of bacterial-type flagellum-dependent cell motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] +synonym: "regulation of bacterial-type flagellar cell motility" RELATED [] +synonym: "regulation of bacterial-type flagellum cell motility" EXACT [] +synonym: "regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +is_a: GO:2000145 ! regulation of cell motility +relationship: regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:1902022 +name: L-lysine transport +namespace: biological_process +def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] +is_a: GO:0006812 ! cation transport +is_a: GO:0006865 ! amino acid transport +is_a: GO:0015807 ! L-amino acid transport + +[Term] +id: GO:1902024 +name: L-histidine transport +namespace: biological_process +def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] +is_a: GO:0006812 ! cation transport +is_a: GO:0015801 ! aromatic amino acid transport +is_a: GO:0015817 ! histidine transport + +[Term] +id: GO:1902025 +name: nitrate import +namespace: biological_process +def: "The directed movement of nitrate into a cell or organelle." [GOC:TermGenie, PMID:22658680] +synonym: "nitrate influx" EXACT [] +synonym: "nitrate uptake" EXACT [] +is_a: GO:0015706 ! nitrate transport + +[Term] +id: GO:1902026 +name: regulation of cartilage condensation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0001502 ! cartilage condensation + +[Term] +id: GO:1902027 +name: positive regulation of cartilage condensation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cartilage condensation." [GOC:TermGenie, PMID:17202865] +synonym: "activation of cartilage condensation" NARROW [GOC:TermGenie] +synonym: "up regulation of cartilage condensation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cartilage condensation" EXACT [GOC:TermGenie] +synonym: "upregulation of cartilage condensation" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1902026 ! regulation of cartilage condensation +relationship: positively_regulates GO:0001502 ! cartilage condensation + +[Term] +id: GO:1902028 +name: regulation of histone H3-K18 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] +synonym: "regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0043971 ! histone H3-K18 acetylation + +[Term] +id: GO:1902029 +name: positive regulation of histone H3-K18 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] +synonym: "activation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "activation of histone H3-K18 acetylation" NARROW [GOC:TermGenie] +synonym: "activation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:1902028 ! regulation of histone H3-K18 acetylation +relationship: positively_regulates GO:0043971 ! histone H3-K18 acetylation + +[Term] +id: GO:1902030 +name: negative regulation of histone H3-K18 acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K18 acetylation." [GOC:TermGenie, PMID:22110608] +synonym: "down regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K18 acetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3-K18 acetylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone H3K18 acetylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone H3 acetylation at K18" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone H3K18 acetylation" EXACT [GOC:TermGenie] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:1902028 ! regulation of histone H3-K18 acetylation +relationship: negatively_regulates GO:0043971 ! histone H3-K18 acetylation + +[Term] +id: GO:1902031 +name: regulation of NADP metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NADP metabolic process." [GOC:TermGenie, PMID:23334421] +synonym: "regulation of NAD phosphorylation and dephosphorylation" RELATED [GOC:TermGenie] +synonym: "regulation of NADP (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of NADP (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of NADP (reduced) metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of NADP (reduced) metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of NADP metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of NADPH metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of NADPH metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized NADP metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized NADP metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of reduced NADP metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of reduced NADP metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0006739 ! NADP metabolic process + +[Term] +id: GO:1902032 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress +namespace: biological_process +def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in response to osmotic stress." [GOC:kmv, GOC:TermGenie, PMID:18636113] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "global transcription regulation from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic response" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in osmotic response" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in osmotic stress response" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in response to osmotic stress" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in osmotic response" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in osmotic stress response" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic response" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in osmotic stress response" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress" EXACT [] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic response" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in osmotic stress response" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in response to osmotic stress" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0006357 +consider: GO:0006970 + +[Term] +id: GO:1902033 +name: regulation of hematopoietic stem cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] +synonym: "regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0072091 ! regulation of stem cell proliferation +relationship: regulates GO:0071425 ! hematopoietic stem cell proliferation + +[Term] +id: GO:1902034 +name: negative regulation of hematopoietic stem cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] +synonym: "down regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation +is_a: GO:1903707 ! negative regulation of hemopoiesis +is_a: GO:2000647 ! negative regulation of stem cell proliferation +relationship: negatively_regulates GO:0071425 ! hematopoietic stem cell proliferation + +[Term] +id: GO:1902035 +name: positive regulation of hematopoietic stem cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation." [GOC:TermGenie, PMID:23403623] +synonym: "activation of hematopoietic stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of hemopoietic stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hematopoietic stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hemopoietic stem cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:1902033 ! regulation of hematopoietic stem cell proliferation +is_a: GO:2000648 ! positive regulation of stem cell proliferation +relationship: positively_regulates GO:0071425 ! hematopoietic stem cell proliferation + +[Term] +id: GO:1902036 +name: regulation of hematopoietic stem cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] +synonym: "regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: regulates GO:0060218 ! hematopoietic stem cell differentiation + +[Term] +id: GO:1902037 +name: negative regulation of hematopoietic stem cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] +synonym: "down regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation +is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation +is_a: GO:2000737 ! negative regulation of stem cell differentiation +relationship: negatively_regulates GO:0060218 ! hematopoietic stem cell differentiation + +[Term] +id: GO:1902038 +name: positive regulation of hematopoietic stem cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation." [GOC:TermGenie, PMID:23403623] +synonym: "activation of haematopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of haemopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of hematopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of hemopoietic stem cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of haematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of haemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of hematopoietic stem cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of hemopoietic stem cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation +is_a: GO:1902036 ! regulation of hematopoietic stem cell differentiation +is_a: GO:2000738 ! positive regulation of stem cell differentiation +relationship: positively_regulates GO:0060218 ! hematopoietic stem cell differentiation + +[Term] +id: GO:1902039 +name: negative regulation of seed dormancy process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449] +synonym: "down regulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "down regulation of seed dormancy process" EXACT [GOC:TermGenie] +synonym: "down-regulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "down-regulation of seed dormancy process" EXACT [GOC:TermGenie] +synonym: "downregulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "downregulation of seed dormancy process" EXACT [GOC:TermGenie] +synonym: "inhibition of seed dormancy" RELATED [GOC:TermGenie] +synonym: "inhibition of seed dormancy process" NARROW [GOC:TermGenie] +synonym: "negative regulation of seed dormancy" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000033 ! regulation of seed dormancy process +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0010162 ! seed dormancy process + +[Term] +id: GO:1902040 +name: positive regulation of seed dormancy process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of seed dormancy process." [GOC:TermGenie, PMID:23378449] +synonym: "activation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "activation of seed dormancy process" NARROW [GOC:TermGenie] +synonym: "positive regulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "up regulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "up regulation of seed dormancy process" EXACT [GOC:TermGenie] +synonym: "up-regulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "up-regulation of seed dormancy process" EXACT [GOC:TermGenie] +synonym: "upregulation of seed dormancy" RELATED [GOC:TermGenie] +synonym: "upregulation of seed dormancy process" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000033 ! regulation of seed dormancy process +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0010162 ! seed dormancy process + +[Term] +id: GO:1902041 +name: regulation of extrinsic apoptotic signaling pathway via death domain receptors +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] +synonym: "regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway +relationship: regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors + +[Term] +id: GO:1902042 +name: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] +synonym: "down regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +synonym: "down-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +synonym: "downregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +synonym: "inhibition of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie] +synonym: "negative regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors +is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors + +[Term] +id: GO:1902043 +name: positive regulation of extrinsic apoptotic signaling pathway via death domain receptors +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors." [GOC:TermGenie, PMID:17245429] +synonym: "activation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of extrinsic apoptotic signaling pathway via death domain receptors" NARROW [GOC:TermGenie] +synonym: "positive regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +synonym: "up-regulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +synonym: "upregulation of death receptor-mediated apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of extrinsic apoptotic signaling pathway via death domain receptors" EXACT [GOC:TermGenie] +is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors +is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors + +[Term] +id: GO:1902044 +name: regulation of Fas signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] +synonym: "regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0036337 ! Fas signaling pathway + +[Term] +id: GO:1902045 +name: negative regulation of Fas signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] +synonym: "down regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of Apo-1 signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of CD95 signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of Fas receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of FasR signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902044 ! regulation of Fas signaling pathway +relationship: negatively_regulates GO:0036337 ! Fas signaling pathway + +[Term] +id: GO:1902046 +name: positive regulation of Fas signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Fas signaling pathway." [GOC:TermGenie, PMID:17245429] +synonym: "activation of Apo-1 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of CD95 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of Fas receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of FasR signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of FasR signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Apo-1 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of CD95 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of FAS ligand-Fas signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of Fas receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Fas signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Fas-FasL signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of FasL signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of FasR signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902044 ! regulation of Fas signaling pathway +relationship: positively_regulates GO:0036337 ! Fas signaling pathway + +[Term] +id: GO:1902047 +name: polyamine transmembrane transport +namespace: biological_process +alt_id: GO:1905122 +def: "The process in which a polyamine macromolecule is transported across a membrane." [GOC:TermGenie, GOC:vw] +synonym: "polyamine import" RELATED [] +synonym: "polyamine uptake" RELATED [PMID:23205587] +is_a: GO:0015846 ! polyamine transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1902048 +name: neosartoricin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "neosartoricin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0030638 ! polyketide metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1900619 ! acetate ester metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:1902049 +name: neosartoricin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "neosartoricin breakdown" EXACT [GOC:TermGenie] +synonym: "neosartoricin catabolism" EXACT [GOC:TermGenie] +synonym: "neosartoricin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0030640 ! polyketide catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1902048 ! neosartoricin metabolic process + +[Term] +id: GO:1902050 +name: neosartoricin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of neosartoricin." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "neosartoricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030639 ! polyketide biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1900620 ! acetate ester biosynthetic process +is_a: GO:1902048 ! neosartoricin metabolic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:1902051 +name: (25S)-Delta(4)-dafachronate binding +namespace: molecular_function +def: "Binding to (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:16529801] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1902052 +name: (25S)-Delta(7)-dafachronate binding +namespace: molecular_function +def: "Binding to (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:16529801] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043177 ! organic acid binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1902053 +name: regulation of neosartoricin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900732 ! regulation of polyketide biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:1902050 ! neosartoricin biosynthetic process + +[Term] +id: GO:1902054 +name: negative regulation of neosartoricin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "down regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of neosartoricin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900733 ! negative regulation of polyketide biosynthetic process +is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:1902050 ! neosartoricin biosynthetic process + +[Term] +id: GO:1902055 +name: positive regulation of neosartoricin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neosartoricin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23368997] +synonym: "activation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of neosartoricin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "activation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of neosartoricin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of neosartoricin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of neosartoricin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of neosartoricin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of neosartoricin synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900734 ! positive regulation of polyketide biosynthetic process +is_a: GO:1902053 ! regulation of neosartoricin biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +relationship: positively_regulates GO:1902050 ! neosartoricin biosynthetic process + +[Term] +id: GO:1902056 +name: (25S)-Delta(7)-dafachronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (25S)-Delta(7)-dafachronate." [GOC:TermGenie, PMID:22505847] +synonym: "(25S)-Delta(7)-dafachronate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:1902057 +name: (25S)-Delta(4)-dafachronate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (25S)-Delta(4)-dafachronate." [GOC:TermGenie, PMID:20178781] +synonym: "(25S)-Delta(4)-dafachronate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0019752 ! carboxylic acid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:1902058 +name: regulation of sporocarp development involved in sexual reproduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] +synonym: "regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +is_a: GO:0031155 ! regulation of reproductive fruiting body development +relationship: regulates GO:0000909 ! sporocarp development involved in sexual reproduction + +[Term] +id: GO:1902059 +name: negative regulation of sporocarp development involved in sexual reproduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] +synonym: "down regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "down regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "down regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "down regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "down regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "down-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "down-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "down-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "down-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +synonym: "downregulation of ascus development" NARROW [GOC:TermGenie] +synonym: "downregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "downregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "downregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "downregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +synonym: "inhibition of ascus development" NARROW [GOC:TermGenie] +synonym: "inhibition of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "inhibition of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "inhibition of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "inhibition of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie] +synonym: "negative regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "negative regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "negative regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "negative regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +is_a: GO:0075262 ! negative regulation of spore-bearing organ development +is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction +relationship: negatively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction + +[Term] +id: GO:1902060 +name: positive regulation of sporocarp development involved in sexual reproduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sporocarp development involved in sexual reproduction." [GOC:di, GOC:TermGenie, PMID:23480775] +synonym: "activation of ascus development" NARROW [GOC:TermGenie] +synonym: "activation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "activation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "activation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "activation of sporocarp development involved in sexual reproduction" NARROW [GOC:TermGenie] +synonym: "positive regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "positive regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "positive regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "positive regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "up regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "up regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "up regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "up regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "up regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of ascus development" NARROW [GOC:TermGenie] +synonym: "up-regulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "up-regulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "up-regulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "up-regulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +synonym: "upregulation of ascus development" NARROW [GOC:TermGenie] +synonym: "upregulation of fruiting body development involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "upregulation of fruiting body formation involved in sexual reproduction" BROAD [GOC:TermGenie] +synonym: "upregulation of perfect stage fruiting body development" NARROW [GOC:TermGenie] +synonym: "upregulation of sporocarp development involved in sexual reproduction" EXACT [GOC:TermGenie] +is_a: GO:0075261 ! positive regulation of spore-bearing organ development +is_a: GO:1902058 ! regulation of sporocarp development involved in sexual reproduction +relationship: positively_regulates GO:0000909 ! sporocarp development involved in sexual reproduction + +[Term] +id: GO:1902061 +name: betaine aldehyde metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] +synonym: "betaine aldehyde metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006807 ! nitrogen compound metabolic process +is_a: GO:0071704 ! organic substance metabolic process + +[Term] +id: GO:1902062 +name: betaine aldehyde catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] +synonym: "betaine aldehyde breakdown" EXACT [GOC:TermGenie] +synonym: "betaine aldehyde catabolism" EXACT [GOC:TermGenie] +synonym: "betaine aldehyde degradation" EXACT [GOC:TermGenie] +is_a: GO:1901575 ! organic substance catabolic process +is_a: GO:1902061 ! betaine aldehyde metabolic process + +[Term] +id: GO:1902063 +name: betaine aldehyde biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of betaine aldehyde." [GOC:di, GOC:TermGenie, PMID:23563483] +synonym: "betaine aldehyde anabolism" EXACT [GOC:TermGenie] +synonym: "betaine aldehyde biosynthesis" EXACT [GOC:TermGenie] +synonym: "betaine aldehyde formation" EXACT [GOC:TermGenie] +synonym: "betaine aldehyde synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901576 ! organic substance biosynthetic process +is_a: GO:1902061 ! betaine aldehyde metabolic process + +[Term] +id: GO:1902064 +name: regulation of transcription from RNA polymerase II promoter involved in spermatogenesis +namespace: biological_process +def: "Any regulation of transcription from RNA polymerase II promoter that is involved in spermatogenesis." [GOC:kmv, GOC:TermGenie, PMID:22570621] +synonym: "global transcription regulation from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] +synonym: "global transcription regulation from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in generation of spermatozoa" RELATED [GOC:TermGenie] +synonym: "regulation of global transcription from Pol II promoter involved in spermatogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from Pol II promoter involved in spermatogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter involved in generation of spermatozoa" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in generation of spermatozoa" RELATED [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in spermatogenesis" RELATED [GOC:TermGenie] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0007283 ! spermatogenesis + +[Term] +id: GO:1902065 +name: response to L-glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus." [GOC:TermGenie, PMID:23574009] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1902066 +name: regulation of cell wall pectin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell wall pectin metabolic process." [GOC:TermGenie, PMID:23453954] +synonym: "regulation of cell wall pectin metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of cellulose and pectin-containing cell wall pectin metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of pectin metabolism during cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of plant-type cell wall pectin metabolic process" EXACT [GOC:TermGenie] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0052546 ! cell wall pectin metabolic process + +[Term] +id: GO:1902068 +name: regulation of sphingolipid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] +synonym: "regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0090520 ! sphingolipid mediated signaling pathway + +[Term] +id: GO:1902069 +name: negative regulation of sphingolipid mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] +synonym: "down regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway +relationship: negatively_regulates GO:0090520 ! sphingolipid mediated signaling pathway + +[Term] +id: GO:1902070 +name: positive regulation of sphingolipid mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sphingolipid signaling." [GOC:TermGenie, PMID:20870412] +synonym: "activation of sphingolipid mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of sphingolipid mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of sphingolipid signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902068 ! regulation of sphingolipid mediated signaling pathway +relationship: positively_regulates GO:0090520 ! sphingolipid mediated signaling pathway + +[Term] +id: GO:1902071 +name: regulation of hypoxia-inducible factor-1alpha signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie] +synonym: "regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway + +[Term] +id: GO:1902072 +name: negative regulation of hypoxia-inducible factor-1alpha signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie] +synonym: "down regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1900038 ! negative regulation of cellular response to hypoxia +is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway +relationship: negatively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway + +[Term] +id: GO:1902073 +name: positive regulation of hypoxia-inducible factor-1alpha signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway." [GOC:bf, GOC:TermGenie, PMID:21685248] +synonym: "activation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "activation of hypoxia-inducible factor-1alpha signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "hypoxic stabilization of HIF1A" NARROW [] +synonym: "positive regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of HIF1alpha pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of hypoxia-inducible factor-1alpha signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of hypoxia-inducible factor-1alpha signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902071 ! regulation of hypoxia-inducible factor-1alpha signaling pathway +relationship: positively_regulates GO:0097411 ! hypoxia-inducible factor-1alpha signaling pathway + +[Term] +id: GO:1902074 +name: response to salt +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] +synonym: "response to salinity" NARROW [GOC:mls] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1902075 +name: cellular response to salt +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." [GOC:mls, GOC:TermGenie, PMID:16666921] +synonym: "cellular response to salinity" NARROW [GOC:mls] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:1902076 +name: regulation of lateral motor column neuron migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] +is_a: GO:1905483 ! regulation of motor neuron migration +relationship: regulates GO:0097477 ! lateral motor column neuron migration + +[Term] +id: GO:1902077 +name: negative regulation of lateral motor column neuron migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] +synonym: "down regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +synonym: "downregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +synonym: "inhibition of lateral motor column neuron migration" NARROW [GOC:TermGenie] +is_a: GO:1902076 ! regulation of lateral motor column neuron migration +is_a: GO:1905484 ! negative regulation of motor neuron migration +relationship: negatively_regulates GO:0097477 ! lateral motor column neuron migration + +[Term] +id: GO:1902078 +name: positive regulation of lateral motor column neuron migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral motor column neuron migration." [GOC:TermGenie, GOC:yaf, PMID:20711475] +synonym: "activation of lateral motor column neuron migration" NARROW [GOC:TermGenie] +synonym: "up regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +synonym: "upregulation of lateral motor column neuron migration" EXACT [GOC:TermGenie] +is_a: GO:1902076 ! regulation of lateral motor column neuron migration +is_a: GO:1905485 ! positive regulation of motor neuron migration +relationship: positively_regulates GO:0097477 ! lateral motor column neuron migration + +[Term] +id: GO:1902079 +name: D-valine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of D-valine." [GOC:TermGenie, PMID:23085840] +synonym: "D-valine breakdown" EXACT [GOC:TermGenie] +synonym: "D-valine catabolism" EXACT [GOC:TermGenie] +synonym: "D-valine degradation" EXACT [GOC:TermGenie] +is_a: GO:0006574 ! valine catabolic process +is_a: GO:0019478 ! D-amino acid catabolic process +is_a: GO:1902114 ! D-valine metabolic process + +[Term] +id: GO:1902080 +name: regulation of calcium ion import into sarcoplasmic reticulum +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0090279 ! regulation of calcium ion import +relationship: regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum + +[Term] +id: GO:1902081 +name: negative regulation of calcium ion import into sarcoplasmic reticulum +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] +synonym: "down regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0090281 ! negative regulation of calcium ion import +is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum +relationship: negatively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum + +[Term] +id: GO:1902082 +name: positive regulation of calcium ion import into sarcoplasmic reticulum +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:8349590] +synonym: "activation of calcium ion import into sarcoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion import into sarcoplasmic reticulum" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0090280 ! positive regulation of calcium ion import +is_a: GO:1902080 ! regulation of calcium ion import into sarcoplasmic reticulum +relationship: positively_regulates GO:1990036 ! calcium ion import into sarcoplasmic reticulum + +[Term] +id: GO:1902083 +name: negative regulation of peptidyl-cysteine S-nitrosylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19198614] +synonym: "down regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "down regulation of S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-cysteine S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "downregulation of S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidyl-cysteine S-nitrosylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "inhibition of S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein S-nitrosylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of S-nitrosylation" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation +relationship: negatively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation + +[Term] +id: GO:1902084 +name: fumagillin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "fumagillin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0097176 ! epoxide metabolic process + +[Term] +id: GO:1902085 +name: fumagillin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "fumagillin breakdown" EXACT [GOC:TermGenie] +synonym: "fumagillin catabolism" EXACT [GOC:TermGenie] +synonym: "fumagillin degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1902084 ! fumagillin metabolic process + +[Term] +id: GO:1902086 +name: fumagillin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fumagillin." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "fumagillin formation" EXACT [GOC:TermGenie] +synonym: "fumagillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1902084 ! fumagillin metabolic process + +[Term] +id: GO:1902087 +name: dimethylsulfoniopropionate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of S,S-dimethyl-beta-propiothetin." [GOC:jh2, GOC:TermGenie, PMID:19807777] +synonym: "S,S-dimethyl-beta-propiothetin breakdown" EXACT [GOC:TermGenie] +synonym: "S,S-dimethyl-beta-propiothetin catabolic process" EXACT [] +synonym: "S,S-dimethyl-beta-propiothetin catabolism" EXACT [GOC:TermGenie] +synonym: "S,S-dimethyl-beta-propiothetin degradation" EXACT [GOC:TermGenie] +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901575 ! organic substance catabolic process + +[Term] +id: GO:1902088 +name: plant-type cell wall loosening involved in abscission +namespace: biological_process +def: "Any plant-type cell wall loosening that is involved in abscission." [GOC:TermGenie, PMID:23479623] +synonym: "cellulose and pectin-containing cell wall loosening involved in abscission" EXACT [GOC:TermGenie] +is_a: GO:0009828 ! plant-type cell wall loosening +is_a: GO:0009830 ! cell wall modification involved in abscission + +[Term] +id: GO:1902089 +name: cell wall polysaccharide catabolic process involved in lateral root development +namespace: biological_process +def: "Any cell wall polysaccharide catabolic process that is involved in lateral root development." [GOC:TermGenie, PMID:23479623] +synonym: "cell wall polysaccharide breakdown involved in lateral root development" EXACT [GOC:TermGenie] +is_a: GO:0044347 ! cell wall polysaccharide catabolic process +relationship: part_of GO:0048527 ! lateral root development + +[Term] +id: GO:1902090 +name: regulation of fumagillin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043455 ! regulation of secondary metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:1902086 ! fumagillin biosynthetic process + +[Term] +id: GO:1902091 +name: negative regulation of fumagillin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "down regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of fumagillin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "inhibition of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1902090 ! regulation of fumagillin biosynthetic process +relationship: negatively_regulates GO:1902086 ! fumagillin biosynthetic process + +[Term] +id: GO:1902092 +name: positive regulation of fumagillin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fumagillin biosynthetic process." [GOC:di, GOC:TermGenie, PMID:23488861] +synonym: "activation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "activation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "activation of fumagillin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "activation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumagillin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of fumagillin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of fumagillin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of fumagillin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of fumagillin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of fumagillin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1902090 ! regulation of fumagillin biosynthetic process +relationship: positively_regulates GO:1902086 ! fumagillin biosynthetic process + +[Term] +id: GO:1902093 +name: positive regulation of flagellated sperm motility +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of flagellated sperm motility." [GOC:cilia, GOC:jh2, GOC:krc, GOC:TermGenie, PMID:7513657] +synonym: "activation of sperm motility" NARROW [GOC:TermGenie] +synonym: "activation of sperm movement" BROAD [GOC:TermGenie] +synonym: "positive regulation of sperm motility" BROAD [] +synonym: "positive regulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "up regulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "up regulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "up-regulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "up-regulation of sperm movement" BROAD [GOC:TermGenie] +synonym: "upregulation of sperm motility" BROAD [GOC:TermGenie] +synonym: "upregulation of sperm movement" BROAD [GOC:TermGenie] +is_a: GO:0003353 ! positive regulation of cilium movement +is_a: GO:1901317 ! regulation of flagellated sperm motility +is_a: GO:2000155 ! positive regulation of cilium-dependent cell motility +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0030317 ! flagellated sperm motility + +[Term] +id: GO:1902097 +name: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in defense response to Gram-negative bacterium." [GOC:kmv, GOC:TermGenie, PMID:17183709] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium + +[Term] +id: GO:1902098 +name: calcitriol binding +namespace: molecular_function +def: "Binding to calcitriol. Calcitriol (1,25-dihydroxycholecalciferol) is the hormonally active form of vitamin D3." [GOC:TermGenie, PMID:21872797, Wikipedia:Calcitriol_receptor] +synonym: "1,25-dihydroxycholecalciferol binding" EXACT [Wikipedia:Calcitriol] +synonym: "1,25-dihydroxyvitamin D3 binding" EXACT [Wikipedia:Calcitriol] +synonym: "1alpha,25(OH)2 vitamin D3 binding" EXACT [PMID:21872797] +synonym: "1alpha,25(OH)2D3 binding" EXACT [CHEBI:17823] +synonym: "1alpha,25-dihydroxycholecalciferol binding" EXACT [CHEBI:17823] +synonym: "1alpha,25-dihydroxyvitamin D3 binding" EXACT [CHEBI:17823] +synonym: "hormonally active vitamin D3 binding" EXACT [GOC:bf] +is_a: GO:1902271 ! D3 vitamins binding + +[Term] +id: GO:1902099 +name: regulation of metaphase/anaphase transition of cell cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +is_a: GO:0033045 ! regulation of sister chromatid segregation +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle + +[Term] +id: GO:1902100 +name: negative regulation of metaphase/anaphase transition of cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "down regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +synonym: "inhibition of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] +is_a: GO:1901988 ! negative regulation of cell cycle phase transition +is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle +relationship: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle + +[Term] +id: GO:1902101 +name: positive regulation of metaphase/anaphase transition of cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] +synonym: "up regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle +relationship: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle + +[Term] +id: GO:1902102 +name: regulation of metaphase/anaphase transition of meiotic cell cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1901993 ! regulation of meiotic cell cycle phase transition +is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle +is_a: GO:1905132 ! regulation of meiotic chromosome separation +relationship: regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle + +[Term] +id: GO:1902103 +name: negative regulation of metaphase/anaphase transition of meiotic cell cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "down regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "down regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "inhibition of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie] +synonym: "negative regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1901994 ! negative regulation of meiotic cell cycle phase transition +is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle +is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905133 ! negative regulation of meiotic chromosome separation +relationship: negatively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle + +[Term] +id: GO:1902104 +name: positive regulation of metaphase/anaphase transition of meiotic cell cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "activation of metaphase/anaphase transition of meiotic cell cycle" NARROW [GOC:TermGenie] +synonym: "positive regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "up regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "up regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic metaphase/anaphase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of metaphase/anaphase transition of meiotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:1901995 ! positive regulation of meiotic cell cycle phase transition +is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle +is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905134 ! positive regulation of meiotic chromosome separation +relationship: positively_regulates GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle + +[Term] +id: GO:1902105 +name: regulation of leukocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] +synonym: "regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:1903706 ! regulation of hemopoiesis +relationship: regulates GO:0002521 ! leukocyte differentiation + +[Term] +id: GO:1902106 +name: negative regulation of leukocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] +synonym: "down regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of leukocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of immune cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of leucocyte differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of leukocyte differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1902105 ! regulation of leukocyte differentiation +is_a: GO:1903707 ! negative regulation of hemopoiesis +relationship: negatively_regulates GO:0002521 ! leukocyte differentiation + +[Term] +id: GO:1902107 +name: positive regulation of leukocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte differentiation." [GOC:add, GOC:TermGenie] +synonym: "activation of immune cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of leucocyte differentiation" NARROW [GOC:TermGenie] +synonym: "activation of leukocyte differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of leukocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of immune cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of leucocyte differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1902105 ! regulation of leukocyte differentiation +is_a: GO:1903708 ! positive regulation of hemopoiesis +relationship: positively_regulates GO:0002521 ! leukocyte differentiation + +[Term] +id: GO:1902108 +name: regulation of mitochondrial membrane permeability involved in apoptotic process +namespace: biological_process +def: "Any regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] +synonym: "regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] +is_a: GO:0008637 ! apoptotic mitochondrial changes +is_a: GO:0046902 ! regulation of mitochondrial membrane permeability + +[Term] +id: GO:1902109 +name: negative regulation of mitochondrial membrane permeability involved in apoptotic process +namespace: biological_process +def: "Any negative regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] +synonym: "mitochondrial membrane impermeability involved in apoptosis" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in apoptotic cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in apoptotic process" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in apoptotic program" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in apoptotic programmed cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in programmed cell death by apoptosis" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeability involved in type I programmed cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in apoptotic process" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane impermeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] +is_a: GO:0035795 ! negative regulation of mitochondrial membrane permeability +is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process + +[Term] +id: GO:1902110 +name: positive regulation of mitochondrial membrane permeability involved in apoptotic process +namespace: biological_process +def: "Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process." [GOC:mtg_apoptosis, GOC:pm, GOC:TermGenie, PMID:19168129] +comment: Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process. +synonym: "mitochondrial membrane permeability transition involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in apoptotic process" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in apoptotic cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in apoptotic process" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in apoptotic cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in apoptotic process" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in programmed cell death by apoptosis" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in type I programmed cell death" NARROW [GOC:TermGenie] +is_a: GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process +is_a: GO:1902686 ! mitochondrial outer membrane permeabilization involved in programmed cell death + +[Term] +id: GO:1902111 +name: response to diethyl maleate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1902112 +name: cellular response to diethyl maleate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902111 ! response to diethyl maleate + +[Term] +id: GO:1902113 +name: nucleotide phosphorylation involved in DNA repair +namespace: biological_process +def: "Any nucleotide phosphorylation that is involved in DNA repair." [GOC:TermGenie, PMID:11729194] +is_a: GO:0046939 ! nucleotide phosphorylation +relationship: part_of GO:0006281 ! DNA repair + +[Term] +id: GO:1902114 +name: D-valine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving D-valine." [GOC:TermGenie, PMID:23085840] +synonym: "D-valine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006573 ! valine metabolic process +is_a: GO:0046416 ! D-amino acid metabolic process + +[Term] +id: GO:1902115 +name: regulation of organelle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0070925 ! organelle assembly + +[Term] +id: GO:1902116 +name: negative regulation of organelle assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] +synonym: "down regulation of organelle assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of organelle assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of organelle assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of organelle assembly" NARROW [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1902115 ! regulation of organelle assembly +relationship: negatively_regulates GO:0070925 ! organelle assembly + +[Term] +id: GO:1902117 +name: positive regulation of organelle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of organelle assembly." [GOC:pr, GOC:TermGenie] +synonym: "activation of organelle assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of organelle assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of organelle assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of organelle assembly" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:1902115 ! regulation of organelle assembly +relationship: positively_regulates GO:0070925 ! organelle assembly + +[Term] +id: GO:1902118 +name: calcidiol binding +namespace: molecular_function +def: "Binding to calcidiol." [GOC:bf, GOC:TermGenie, PMID:11799400] +synonym: "25(OH)D3 binding" EXACT [CHEBI:17933] +synonym: "25-hydroxycholecalciferol binding" EXACT [CHEBI:17933] +synonym: "25-hydroxyvitamin D3 binding" EXACT [CHEBI:17933] +synonym: "25OHD3 binding" EXACT [PMID:11799400] +synonym: "calcifediol binding" EXACT [CHEBI:17933] +is_a: GO:1902271 ! D3 vitamins binding + +[Term] +id: GO:1902119 +name: regulation of meiotic spindle elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] +synonym: "regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] +is_a: GO:0032887 ! regulation of spindle elongation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0051232 ! meiotic spindle elongation + +[Term] +id: GO:1902120 +name: negative regulation of meiotic spindle elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation." [GOC:TermGenie, PMID:23370392] +synonym: "down regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "down regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic spindle elongation" NARROW [GOC:TermGenie] +synonym: "inhibition of spindle elongation during meiosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of spindle elongation during meiosis" EXACT [GOC:TermGenie] +is_a: GO:0045835 ! negative regulation of meiotic nuclear division +is_a: GO:1902119 ! regulation of meiotic spindle elongation +relationship: negatively_regulates GO:0051232 ! meiotic spindle elongation + +[Term] +id: GO:1902121 +name: lithocholic acid binding +namespace: molecular_function +def: "Binding to lithocholic acid." [GOC:bf, GOC:TermGenie, PMID:20371703] +synonym: "LCA binding" EXACT [PMID:20371703] +is_a: GO:0005496 ! steroid binding +is_a: GO:0032052 ! bile acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:1902122 +name: chenodeoxycholic acid binding +namespace: molecular_function +def: "Binding to chenodeoxycholic acid." [GOC:bf, GOC:TermGenie, PMID:10334992] +synonym: "CDCA binding" EXACT [CHEBI:16755] +is_a: GO:0005496 ! steroid binding +is_a: GO:0032052 ! bile acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:1902123 +name: (-)-pinoresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-pinoresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(-)-pinoresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-pinoresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-pinoresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1901598 ! (-)-pinoresinol metabolic process + +[Term] +id: GO:1902124 +name: (+)-pinoresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-pinoresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0042537 ! benzene-containing compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1902125 +name: (+)-pinoresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-pinoresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(+)-pinoresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(+)-pinoresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1902124 ! (+)-pinoresinol metabolic process + +[Term] +id: GO:1902126 +name: (+)-pinoresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-pinoresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-pinoresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-pinoresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-pinoresinol formation" EXACT [GOC:TermGenie] +synonym: "(+)-pinoresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1902124 ! (+)-pinoresinol metabolic process + +[Term] +id: GO:1902127 +name: (-)-lariciresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(-)-lariciresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1902128 +name: (-)-lariciresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(-)-lariciresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-lariciresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-lariciresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1902127 ! (-)-lariciresinol metabolic process + +[Term] +id: GO:1902129 +name: (-)-lariciresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-lariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(-)-lariciresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-lariciresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-lariciresinol formation" EXACT [GOC:TermGenie] +synonym: "(-)-lariciresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1902127 ! (-)-lariciresinol metabolic process + +[Term] +id: GO:1902130 +name: (+)-lariciresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-lariciresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0046483 ! heterocycle metabolic process + +[Term] +id: GO:1902131 +name: (+)-lariciresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-lariciresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(+)-lariciresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(+)-lariciresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1902130 ! (+)-lariciresinol metabolic process + +[Term] +id: GO:1902132 +name: (+)-lariciresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-lariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(+)-lariciresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-lariciresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-lariciresinol formation" EXACT [GOC:TermGenie] +synonym: "(+)-lariciresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1902130 ! (+)-lariciresinol metabolic process + +[Term] +id: GO:1902133 +name: (+)-secoisolariciresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(+)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:1902134 +name: (+)-secoisolariciresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(+)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(+)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(+)-secoisolariciresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process + +[Term] +id: GO:1902135 +name: (+)-secoisolariciresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (+)-secoisolariciresinol." [GOC:TermGenie, PMID:15949826, PMID:9872995] +synonym: "(+)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(+)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(+)-secoisolariciresinol formation" EXACT [GOC:TermGenie] +synonym: "(+)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1902133 ! (+)-secoisolariciresinol metabolic process + +[Term] +id: GO:1902136 +name: (-)-secoisolariciresinol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(-)-secoisolariciresinol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009806 ! lignan metabolic process +is_a: GO:0018958 ! phenol-containing compound metabolic process +is_a: GO:0034311 ! diol metabolic process + +[Term] +id: GO:1902137 +name: (-)-secoisolariciresinol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(-)-secoisolariciresinol breakdown" EXACT [GOC:TermGenie] +synonym: "(-)-secoisolariciresinol catabolism" EXACT [GOC:TermGenie] +synonym: "(-)-secoisolariciresinol degradation" EXACT [GOC:TermGenie] +is_a: GO:0019336 ! phenol-containing compound catabolic process +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0046273 ! lignan catabolic process +is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process + +[Term] +id: GO:1902138 +name: (-)-secoisolariciresinol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (-)-secoisolariciresinol." [GOC:TermGenie, PMID:8910615, PMID:9872995] +synonym: "(-)-secoisolariciresinol anabolism" EXACT [GOC:TermGenie] +synonym: "(-)-secoisolariciresinol biosynthesis" EXACT [GOC:TermGenie] +synonym: "(-)-secoisolariciresinol formation" EXACT [GOC:TermGenie] +synonym: "(-)-secoisolariciresinol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009807 ! lignan biosynthetic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0046189 ! phenol-containing compound biosynthetic process +is_a: GO:1902136 ! (-)-secoisolariciresinol metabolic process + +[Term] +id: GO:1902140 +name: response to inositol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1902141 +name: cellular response to inositol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus." [GOC:TermGenie, PMID:16496115] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902140 ! response to inositol + +[Term] +id: GO:1902145 +name: regulation of response to cell cycle checkpoint signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:1902146 +name: positive regulation of response to cell cycle checkpoint signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to cell cycle checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "activation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "activation of response to cell cycle checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "activation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "activation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "activation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "activation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "positive regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "positive regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +synonym: "up regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "up regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "up regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "up regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "up regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "up-regulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "up-regulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +synonym: "upregulation of cell cycle checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of G1/S transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "upregulation of G2/M transition checkpoint effector process" RELATED [GOC:TermGenie] +synonym: "upregulation of response to cell cycle checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to G1/S transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of response to G2/M transition checkpoint signaling" RELATED [GOC:TermGenie] +synonym: "upregulation of response to signal involved in cell cycle checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in G1/S transition checkpoint" RELATED [GOC:TermGenie] +synonym: "upregulation of response to signal involved in G2/M transition checkpoint" RELATED [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling +relationship: positively_regulates GO:0072396 ! response to cell cycle checkpoint signaling + +[Term] +id: GO:1902147 +name: regulation of response to cytokinesis checkpoint signaling +namespace: biological_process +alt_id: GO:1902149 +def: "Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling +relationship: regulates GO:0072399 ! response to cytokinesis checkpoint signaling + +[Term] +id: GO:1902148 +name: positive regulation of response to cytokinesis checkpoint signaling +namespace: biological_process +alt_id: GO:1902150 +def: "Any process that activates or increases the frequency, rate or extent of response to cytokinesis checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of response to cytokinesis checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of cytokinesis checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of response to cytokinesis checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in cytokinesis checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling +is_a: GO:1902147 ! regulation of response to cytokinesis checkpoint signaling +relationship: positively_regulates GO:0072399 ! response to cytokinesis checkpoint signaling + +[Term] +id: GO:1902151 +name: regulation of response to DNA integrity checkpoint signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902145 ! regulation of response to cell cycle checkpoint signaling +relationship: regulates GO:0072402 ! response to DNA integrity checkpoint signaling + +[Term] +id: GO:1902152 +name: positive regulation of response to DNA integrity checkpoint signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of response to DNA integrity checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA integrity checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of response to DNA integrity checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in DNA integrity checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902146 ! positive regulation of response to cell cycle checkpoint signaling +is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling +relationship: positively_regulates GO:0072402 ! response to DNA integrity checkpoint signaling + +[Term] +id: GO:1902153 +name: regulation of response to DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902151 ! regulation of response to DNA integrity checkpoint signaling +relationship: regulates GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:1902154 +name: positive regulation of response to DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of response to DNA damage checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of response to DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902152 ! positive regulation of response to DNA integrity checkpoint signaling +is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling +relationship: positively_regulates GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:1902155 +name: regulation of response to G1 DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling +relationship: regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling + +[Term] +id: GO:1902156 +name: positive regulation of response to G1 DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of response to G1 DNA damage checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "activation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic cell cycle G1/S transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of response to G1 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling +is_a: GO:1902155 ! regulation of response to G1 DNA damage checkpoint signaling +relationship: positively_regulates GO:0072432 ! response to G1 DNA damage checkpoint signaling + +[Term] +id: GO:1902157 +name: regulation of response to G2 DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902153 ! regulation of response to DNA damage checkpoint signaling +relationship: regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling + +[Term] +id: GO:1902158 +name: positive regulation of response to G2 DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to G2 DNA damage checkpoint signaling." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "activation of response to G2 DNA damage checkpoint signaling" NARROW [GOC:TermGenie] +synonym: "activation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "positive regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of G2/M transition DNA damage checkpoint effector process" EXACT [GOC:TermGenie] +synonym: "upregulation of response to G2 DNA damage checkpoint signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:1902154 ! positive regulation of response to DNA damage checkpoint signaling +is_a: GO:1902157 ! regulation of response to G2 DNA damage checkpoint signaling +relationship: positively_regulates GO:0072426 ! response to G2 DNA damage checkpoint signaling + +[Term] +id: GO:1902159 +name: regulation of cyclic nucleotide-gated ion channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] +synonym: "regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:1902160 +name: negative regulation of cyclic nucleotide-gated ion channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] +synonym: "down regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity + +[Term] +id: GO:1902161 +name: positive regulation of cyclic nucleotide-gated ion channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." [GOC:TermGenie, PMID:11420311] +synonym: "activation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "activation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "activation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "activation of cyclic nucleotide-gated ion channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclic nucleotide activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclic nucleotide gated ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclic nucleotide-activated ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclic nucleotide-gated ion channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1902159 ! regulation of cyclic nucleotide-gated ion channel activity + +[Term] +id: GO:1902162 +name: regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541] +is_a: GO:0043516 ! regulation of DNA damage response, signal transduction by p53 class mediator +relationship: regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + +[Term] +id: GO:1902163 +name: negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541] +synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie] +is_a: GO:0043518 ! negative regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +relationship: negatively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + +[Term] +id: GO:1902164 +name: positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator." [GOC:TermGenie, PMID:17719541] +synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" EXACT [GOC:TermGenie] +is_a: GO:0043517 ! positive regulation of DNA damage response, signal transduction by p53 class mediator +is_a: GO:1902162 ! regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator +relationship: positively_regulates GO:0006978 ! DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator + +[Term] +id: GO:1902165 +name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] +synonym: "regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + +[Term] +id: GO:1902166 +name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] +synonym: "down regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +is_a: GO:1902230 ! negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: negatively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + +[Term] +id: GO:1902167 +name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator." [GOC:TermGenie, PMID:17719541] +synonym: "activation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" EXACT [GOC:TermGenie] +is_a: GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator +is_a: GO:1902231 ! positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: positively_regulates GO:0042771 ! intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + +[Term] +id: GO:1902168 +name: response to catechin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620] +is_a: GO:0080184 ! response to phenylpropanoid +is_a: GO:1905395 ! response to flavonoid + +[Term] +id: GO:1902169 +name: cellular response to catechin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catechin stimulus." [GOC:rjd, GOC:TermGenie, PMID:23516620] +is_a: GO:1902168 ! response to catechin +is_a: GO:1905396 ! cellular response to flavonoid +is_a: GO:1905546 ! cellular response to phenylpropanoid + +[Term] +id: GO:1902170 +name: cellular response to reactive nitrogen species +namespace: biological_process +alt_id: GO:1990106 +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638] +is_a: GO:1901699 ! cellular response to nitrogen compound + +[Term] +id: GO:1902171 +name: regulation of tocopherol cyclase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tocopherol cyclase activity." [GOC:TermGenie, PMID:23632854] +is_a: GO:0031279 ! regulation of cyclase activity + +[Term] +id: GO:1902172 +name: regulation of keratinocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] +synonym: "regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:0097283 ! keratinocyte apoptotic process + +[Term] +id: GO:1902173 +name: negative regulation of keratinocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] +synonym: "down regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of keratinocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1902172 ! regulation of keratinocyte apoptotic process +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +relationship: negatively_regulates GO:0097283 ! keratinocyte apoptotic process + +[Term] +id: GO:1902174 +name: positive regulation of keratinocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:18938133] +synonym: "activation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of keratinocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of keratinocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of keratinocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1902172 ! regulation of keratinocyte apoptotic process +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +relationship: positively_regulates GO:0097283 ! keratinocyte apoptotic process + +[Term] +id: GO:1902175 +name: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] +synonym: "regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] +is_a: GO:1903201 ! regulation of oxidative stress-induced cell death +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1902176 +name: negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] +is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1902177 +name: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:TermGenie, PMID:11672522] +synonym: "activation of intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:bf] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1902178 +name: fibroblast growth factor receptor apoptotic signaling pathway +namespace: biological_process +def: "An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR)." [GOC:mtg_apoptosis, GOC:pm, GOC:pr, GOC:TermGenie, PMID:17561467] +synonym: "FGF receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "FGF receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "FGF receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "FGFR signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic process" EXACT [GOC:pm] +synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signaling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic cell death" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic process" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic program" NARROW [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis" EXACT [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity" RELATED [GOC:TermGenie] +synonym: "fibroblast growth factor receptor signalling pathway involved in type I programmed cell death" NARROW [GOC:TermGenie] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +is_a: GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:1902179 +name: verruculogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] +synonym: "verruculogen metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0018904 ! ether metabolic process +is_a: GO:0034311 ! diol metabolic process +is_a: GO:0035834 ! indole alkaloid metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1902180 +name: verruculogen catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] +synonym: "verruculogen breakdown" EXACT [GOC:TermGenie] +synonym: "verruculogen catabolism" EXACT [GOC:TermGenie] +synonym: "verruculogen degradation" EXACT [GOC:TermGenie] +is_a: GO:0009822 ! alkaloid catabolic process +is_a: GO:0019439 ! aromatic compound catabolic process +is_a: GO:0034313 ! diol catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:1901502 ! ether catabolic process +is_a: GO:1902179 ! verruculogen metabolic process + +[Term] +id: GO:1902181 +name: verruculogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of verruculogen." [GOC:di, GOC:TermGenie, PMID:23649274] +synonym: "verruculogen anabolism" EXACT [GOC:TermGenie] +synonym: "verruculogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "verruculogen formation" EXACT [GOC:TermGenie] +synonym: "verruculogen synthesis" EXACT [GOC:TermGenie] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0019748 ! secondary metabolic process +is_a: GO:0034312 ! diol biosynthetic process +is_a: GO:0035835 ! indole alkaloid biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901503 ! ether biosynthetic process +is_a: GO:1902179 ! verruculogen metabolic process + +[Term] +id: GO:1902182 +name: shoot apical meristem development +namespace: biological_process +def: "The process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure." [GOC:TermGenie, PMID:21496644] +synonym: "primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "promeristem development" BROAD [GOC:TermGenie] +synonym: "SAM development" EXACT [GOC:TermGenie] +is_a: GO:0048507 ! meristem development + +[Term] +id: GO:1902183 +name: regulation of shoot apical meristem development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] +synonym: "regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "regulation of SAM development" EXACT [GOC:TermGenie] +is_a: GO:0048509 ! regulation of meristem development +relationship: regulates GO:1902182 ! shoot apical meristem development + +[Term] +id: GO:1902184 +name: negative regulation of shoot apical meristem development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] +synonym: "down regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "down regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "down regulation of SAM development" EXACT [GOC:TermGenie] +synonym: "down regulation of shoot apical meristem development" EXACT [GOC:TermGenie] +synonym: "down-regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "down-regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "down-regulation of SAM development" EXACT [GOC:TermGenie] +synonym: "down-regulation of shoot apical meristem development" EXACT [GOC:TermGenie] +synonym: "downregulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "downregulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "downregulation of SAM development" EXACT [GOC:TermGenie] +synonym: "downregulation of shoot apical meristem development" EXACT [GOC:TermGenie] +synonym: "inhibition of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "inhibition of promeristem development" BROAD [GOC:TermGenie] +synonym: "inhibition of SAM development" EXACT [GOC:TermGenie] +synonym: "inhibition of shoot apical meristem development" NARROW [GOC:TermGenie] +synonym: "negative regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "negative regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "negative regulation of SAM development" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1902183 ! regulation of shoot apical meristem development +relationship: negatively_regulates GO:1902182 ! shoot apical meristem development + +[Term] +id: GO:1902185 +name: positive regulation of shoot apical meristem development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of shoot apical meristem development." [GOC:TermGenie, PMID:21496644] +synonym: "activation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "activation of promeristem development" BROAD [GOC:TermGenie] +synonym: "activation of SAM development" EXACT [GOC:TermGenie] +synonym: "activation of shoot apical meristem development" NARROW [GOC:TermGenie] +synonym: "positive regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "positive regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "positive regulation of SAM development" EXACT [GOC:TermGenie] +synonym: "up regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "up regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "up regulation of SAM development" EXACT [GOC:TermGenie] +synonym: "up regulation of shoot apical meristem development" EXACT [GOC:TermGenie] +synonym: "up-regulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "up-regulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "up-regulation of SAM development" EXACT [GOC:TermGenie] +synonym: "up-regulation of shoot apical meristem development" EXACT [GOC:TermGenie] +synonym: "upregulation of primary shoot meristem development" RELATED [GOC:TermGenie] +synonym: "upregulation of promeristem development" BROAD [GOC:TermGenie] +synonym: "upregulation of SAM development" EXACT [GOC:TermGenie] +synonym: "upregulation of shoot apical meristem development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1902183 ! regulation of shoot apical meristem development +relationship: positively_regulates GO:1902182 ! shoot apical meristem development + +[Term] +id: GO:1902186 +name: obsolete regulation of viral release from host cell +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167] +comment: This term was obsoleted because there is no evidence that it is a regulated process. +synonym: "regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "regulation of viral release" EXACT [GOC:TermGenie] +synonym: "regulation of viral shedding" EXACT [GOC:TermGenie] +is_obsolete: true +replaced_by: GO:0019076 + +[Term] +id: GO:1902188 +name: obsolete positive regulation of viral release from host cell +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of viral release from host cell." [GOC:TermGenie, PMID:18305167] +comment: This term was obsoleted because there is no evidence that it is a regulated process. +synonym: "activation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "activation of viral exit" EXACT [GOC:TermGenie] +synonym: "activation of viral release" EXACT [GOC:TermGenie] +synonym: "activation of viral release from host cell" NARROW [GOC:TermGenie] +synonym: "activation of viral shedding" EXACT [GOC:TermGenie] +synonym: "positive regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral release" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "up regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "up regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "up regulation of viral release" EXACT [GOC:TermGenie] +synonym: "up regulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "up regulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "up-regulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral exit" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral release" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral shedding" EXACT [GOC:TermGenie] +synonym: "upregulation of release of virus from host" EXACT [GOC:TermGenie] +synonym: "upregulation of viral exit" EXACT [GOC:TermGenie] +synonym: "upregulation of viral release" EXACT [GOC:TermGenie] +synonym: "upregulation of viral release from host cell" EXACT [GOC:TermGenie] +synonym: "upregulation of viral shedding" EXACT [GOC:TermGenie] +is_obsolete: true +replaced_by: GO:0019076 + +[Term] +id: GO:1902189 +name: 2-methylbutanoyl-CoA(4-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbutanoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:1902190 +name: 2-methylbutanoyl-CoA(4-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbutanoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] +synonym: "2-methylbutanoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] +synonym: "2-methylbutanoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process +is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902191 +name: 2-methylbutanoyl-CoA(4-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-methylbutanoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbutanoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] +synonym: "2-methylbutanoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "2-methylbutanoyl-CoA(4-) formation" EXACT [GOC:TermGenie] +synonym: "2-methylbutanoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process +is_a: GO:1902189 ! 2-methylbutanoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902192 +name: 2-methylbut-2-enoyl-CoA(4-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:1902193 +name: 2-methylbut-2-enoyl-CoA(4-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] +synonym: "2-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] +synonym: "2-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process +is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902194 +name: 2-methylbut-2-enoyl-CoA(4-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 2-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, PMID:15574432] +synonym: "2-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] +synonym: "2-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "2-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie] +synonym: "2-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process +is_a: GO:1902192 ! 2-methylbut-2-enoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902195 +name: isovaleryl-CoA(4-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "isovaleryl-CoA(4-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:1902196 +name: isovaleryl-CoA(4-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "isovaleryl-CoA(4-) breakdown" EXACT [GOC:TermGenie] +synonym: "isovaleryl-CoA(4-) catabolism" EXACT [GOC:TermGenie] +synonym: "isovaleryl-CoA(4-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process +is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process + +[Term] +id: GO:1902197 +name: isovaleryl-CoA(4-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "isovaleryl-CoA(4-) anabolism" EXACT [GOC:TermGenie] +synonym: "isovaleryl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "isovaleryl-CoA(4-) formation" EXACT [GOC:TermGenie] +synonym: "isovaleryl-CoA(4-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process +is_a: GO:1902195 ! isovaleryl-CoA(4-) metabolic process + +[Term] +id: GO:1902198 +name: 3-methylbut-2-enoyl-CoA(4-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "3-methylbut-2-enoyl-CoA(4-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0035337 ! fatty-acyl-CoA metabolic process + +[Term] +id: GO:1902199 +name: 3-methylbut-2-enoyl-CoA(4-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "3-methylbut-2-enoyl-CoA(4-) breakdown" EXACT [GOC:TermGenie] +synonym: "3-methylbut-2-enoyl-CoA(4-) catabolism" EXACT [GOC:TermGenie] +synonym: "3-methylbut-2-enoyl-CoA(4-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0036115 ! fatty-acyl-CoA catabolic process +is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902200 +name: 3-methylbut-2-enoyl-CoA(4-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-methylbut-2-enoyl-CoA(4-)." [GOC:TermGenie, pmid:11231285] +synonym: "3-methylbut-2-enoyl-CoA(4-) anabolism" EXACT [GOC:TermGenie] +synonym: "3-methylbut-2-enoyl-CoA(4-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "3-methylbut-2-enoyl-CoA(4-) formation" EXACT [GOC:TermGenie] +synonym: "3-methylbut-2-enoyl-CoA(4-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046949 ! fatty-acyl-CoA biosynthetic process +is_a: GO:1902198 ! 3-methylbut-2-enoyl-CoA(4-) metabolic process + +[Term] +id: GO:1902201 +name: negative regulation of bacterial-type flagellum-dependent cell motility +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility." [GOC:cilia, GOC:jl, GOC:TermGenie] +synonym: "down regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "down regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "down-regulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "down-regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "downregulation of bacterial-type flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "downregulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "inhibition of bacterial-type flagellar cell motility" NARROW [GOC:TermGenie] +synonym: "inhibition of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +synonym: "negative regulation of bacterial-type flagellar cell motility" RELATED [] +synonym: "negative regulation of flagellin-based flagellar cell motility" EXACT [GOC:TermGenie] +is_a: GO:1902021 ! regulation of bacterial-type flagellum-dependent cell motility +is_a: GO:2000146 ! negative regulation of cell motility +relationship: negatively_regulates GO:0071973 ! bacterial-type flagellum-dependent cell motility + +[Term] +id: GO:1902202 +name: regulation of hepatocyte growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] +synonym: "regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of Met signaling pathway" NARROW [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway + +[Term] +id: GO:1902203 +name: negative regulation of hepatocyte growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] +synonym: "down regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of Met signaling pathway" NARROW [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway +relationship: negatively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway + +[Term] +id: GO:1902204 +name: positive regulation of hepatocyte growth factor receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway." [GOC:TermGenie, PMID:18819921] +synonym: "activation of hepatocyte growth factor receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "activation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "activation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of Met signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of hepatocyte growth factor receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of HGF receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of HGF receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of Met signaling pathway" NARROW [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902202 ! regulation of hepatocyte growth factor receptor signaling pathway +relationship: positively_regulates GO:0048012 ! hepatocyte growth factor receptor signaling pathway + +[Term] +id: GO:1902205 +name: regulation of interleukin-2-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] +synonym: "regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0038110 ! interleukin-2-mediated signaling pathway + +[Term] +id: GO:1902206 +name: negative regulation of interleukin-2-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] +synonym: "down regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway +relationship: negatively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway + +[Term] +id: GO:1902207 +name: positive regulation of interleukin-2-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-2-mediated signaling pathway." [GOC:TermGenie, PMID:11909529] +synonym: "activation of IL-2-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-2-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-2-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of IL-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-2-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-2-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1902205 ! regulation of interleukin-2-mediated signaling pathway +relationship: positively_regulates GO:0038110 ! interleukin-2-mediated signaling pathway + +[Term] +id: GO:1902208 +name: regulation of bacterial-type flagellum assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] +synonym: "regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +is_a: GO:0060491 ! regulation of cell projection assembly +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0044780 ! bacterial-type flagellum assembly + +[Term] +id: GO:1902209 +name: negative regulation of bacterial-type flagellum assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] +synonym: "down regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of bacterial flagellum assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of bacterial-type flagellum assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly +relationship: negatively_regulates GO:0044780 ! bacterial-type flagellum assembly + +[Term] +id: GO:1902210 +name: positive regulation of bacterial-type flagellum assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bacterial-type flagellum assembly." [GOC:jl, GOC:TermGenie] +synonym: "activation of bacterial flagellum assembly" NARROW [GOC:TermGenie] +synonym: "activation of bacterial-type flagellum assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of bacterial flagellum assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of bacterial-type flagellum assembly" EXACT [GOC:TermGenie] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:1902208 ! regulation of bacterial-type flagellum assembly +relationship: positively_regulates GO:0044780 ! bacterial-type flagellum assembly + +[Term] +id: GO:1902211 +name: regulation of prolactin signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] +synonym: "regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0038161 ! prolactin signaling pathway + +[Term] +id: GO:1902212 +name: negative regulation of prolactin signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] +synonym: "down regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of PRL signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of prolactin signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1902211 ! regulation of prolactin signaling pathway +relationship: negatively_regulates GO:0038161 ! prolactin signaling pathway + +[Term] +id: GO:1902213 +name: positive regulation of prolactin signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway." [GOC:TermGenie, PMID:11773439] +synonym: "activation of PRL signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of prolactin signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of prolactin-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of PRL signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of prolactin signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of prolactin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1902211 ! regulation of prolactin signaling pathway +relationship: positively_regulates GO:0038161 ! prolactin signaling pathway + +[Term] +id: GO:1902214 +name: regulation of interleukin-4-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] +synonym: "regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0035771 ! interleukin-4-mediated signaling pathway + +[Term] +id: GO:1902215 +name: negative regulation of interleukin-4-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] +synonym: "down regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway +relationship: negatively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway + +[Term] +id: GO:1902216 +name: positive regulation of interleukin-4-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway." [GOC:TermGenie, PMID:17210636] +synonym: "activation of IL-4-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-4-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-4-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of IL-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-4-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-4-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1902214 ! regulation of interleukin-4-mediated signaling pathway +relationship: positively_regulates GO:0035771 ! interleukin-4-mediated signaling pathway + +[Term] +id: GO:1902217 +name: erythrocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in an erythrocyte." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "red blood cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0033028 ! myeloid cell apoptotic process + +[Term] +id: GO:1902218 +name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +is_a: GO:0106049 ! regulation of cellular response to osmotic stress +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress + +[Term] +id: GO:1902219 +name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie] +is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress + +[Term] +id: GO:1902220 +name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress" NARROW [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress" EXACT [GOC:TermGenie] +is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress + +[Term] +id: GO:1902221 +name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1902222 +name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid breakdown" EXACT [GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolism" EXACT [GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid degradation" EXACT [GOC:TermGenie] +is_a: GO:1901606 ! alpha-amino acid catabolic process +is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process + +[Term] +id: GO:1902223 +name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of erythrose 4-phosphate/phosphoenolpyruvate family amino acid." [GOC:pr, GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid anabolism" EXACT [GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid formation" EXACT [GOC:TermGenie] +synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901607 ! alpha-amino acid biosynthetic process +is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process + +[Term] +id: GO:1902224 +name: ketone body metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ketone body." [GOC:pr, GOC:TermGenie] +synonym: "ketone body metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006091 ! generation of precursor metabolites and energy +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:1902225 +name: negative regulation of acrosome reaction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction." [GOC:TermGenie, PMID:23430248] +synonym: "down regulation of acrosome reaction" EXACT [GOC:TermGenie] +synonym: "down-regulation of acrosome reaction" EXACT [GOC:TermGenie] +synonym: "downregulation of acrosome reaction" EXACT [GOC:TermGenie] +synonym: "inhibition of acrosome reaction" NARROW [GOC:TermGenie] +is_a: GO:0060046 ! regulation of acrosome reaction +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007340 ! acrosome reaction + +[Term] +id: GO:1902226 +name: regulation of macrophage colony-stimulating factor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] +synonym: "regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus +relationship: regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway + +[Term] +id: GO:1902227 +name: negative regulation of macrophage colony-stimulating factor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] +synonym: "down regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of M-CSF signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway +relationship: negatively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway + +[Term] +id: GO:1902228 +name: positive regulation of macrophage colony-stimulating factor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway." [GOC:TermGenie, PMID:16705167] +synonym: "activation of M-CSF signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of macrophage colony-stimulating factor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of macrophage colony-stimulating factor signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of M-CSF signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of macrophage colony-stimulating factor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of macrophage colony-stimulating factor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1902226 ! regulation of macrophage colony-stimulating factor signaling pathway +relationship: positively_regulates GO:0038145 ! macrophage colony-stimulating factor signaling pathway + +[Term] +id: GO:1902229 +name: regulation of intrinsic apoptotic signaling pathway in response to DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] +synonym: "regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage + +[Term] +id: GO:1902230 +name: negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] +synonym: "down regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage + +[Term] +id: GO:1902231 +name: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15314165] +synonym: "activation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to DNA damage" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to DNA damage" EXACT [GOC:TermGenie] +is_a: GO:1902229 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage +is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage + +[Term] +id: GO:1902232 +name: regulation of positive thymic T cell selection +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] +synonym: "regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +is_a: GO:0033081 ! regulation of T cell differentiation in thymus +relationship: regulates GO:0045059 ! positive thymic T cell selection + +[Term] +id: GO:1902233 +name: negative regulation of positive thymic T cell selection +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] +synonym: "down regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "down regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "down regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "down regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "downregulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "downregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "downregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "downregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "inhibition of positive thymic T cell selection" NARROW [GOC:TermGenie] +synonym: "inhibition of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie] +synonym: "inhibition of positive thymic T-cell selection" NARROW [GOC:TermGenie] +synonym: "inhibition of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie] +synonym: "negative regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "negative regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "negative regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus +is_a: GO:1902232 ! regulation of positive thymic T cell selection +relationship: negatively_regulates GO:0045059 ! positive thymic T cell selection + +[Term] +id: GO:1902234 +name: positive regulation of positive thymic T cell selection +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection." [GOC:TermGenie, PMID:22080863] +synonym: "activation of positive thymic T cell selection" NARROW [GOC:TermGenie] +synonym: "activation of positive thymic T lymphocyte selection" NARROW [GOC:TermGenie] +synonym: "activation of positive thymic T-cell selection" NARROW [GOC:TermGenie] +synonym: "activation of positive thymic T-lymphocyte selection" NARROW [GOC:TermGenie] +synonym: "positive regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "positive regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "positive regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "up regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "up regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "up regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "up regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "up-regulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "up-regulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "up-regulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "up-regulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "upregulation of positive thymic T cell selection" EXACT [GOC:TermGenie] +synonym: "upregulation of positive thymic T lymphocyte selection" EXACT [GOC:TermGenie] +synonym: "upregulation of positive thymic T-cell selection" EXACT [GOC:TermGenie] +synonym: "upregulation of positive thymic T-lymphocyte selection" EXACT [GOC:TermGenie] +is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus +is_a: GO:1902232 ! regulation of positive thymic T cell selection +relationship: positively_regulates GO:0045059 ! positive thymic T cell selection + +[Term] +id: GO:1902235 +name: regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] +synonym: "regulation of apoptosis in response to endoplasmic reticulum stress" BROAD [GOC:TermGenie] +synonym: "regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + +[Term] +id: GO:1902236 +name: negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] +synonym: "down regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptosis in response to ER stress" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis triggered by ER stress" NARROW [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of ER stress-induced apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "negative regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + +[Term] +id: GO:1902237 +name: positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:20160352] +synonym: "activation of apoptosis in response to ER stress" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis triggered by ER stress" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum stress-induced apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of ER stress-induced apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "positive regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "up regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptosis in response to ER stress" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptosis triggered by ER stress" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of ER stress-induced apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + +[Term] +id: GO:1902238 +name: regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] +is_a: GO:1902218 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + +[Term] +id: GO:1902239 +name: negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie] +is_a: GO:1902219 ! negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +is_a: GO:1902254 ! negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: negatively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + +[Term] +id: GO:1902240 +name: positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator." [GOC:krc, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16571598] +synonym: "activation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator" EXACT [GOC:TermGenie] +is_a: GO:1902220 ! positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:1902238 ! regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +is_a: GO:1902255 ! positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator +relationship: positively_regulates GO:1990127 ! intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + +[Term] +id: GO:1902241 +name: copal-8-ol diphosphate(3-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] +synonym: "copal-8-ol diphosphate(3-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0016101 ! diterpenoid metabolic process + +[Term] +id: GO:1902242 +name: copal-8-ol diphosphate(3-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] +synonym: "copal-8-ol diphosphate(3-) breakdown" EXACT [GOC:TermGenie] +synonym: "copal-8-ol diphosphate(3-) catabolism" EXACT [GOC:TermGenie] +synonym: "copal-8-ol diphosphate(3-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0016103 ! diterpenoid catabolic process +is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process + +[Term] +id: GO:1902243 +name: copal-8-ol diphosphate(3-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of copal-8-ol diphosphate(3-)." [GOC:TermGenie, pmid:22672125] +synonym: "copal-8-ol diphosphate(3-) anabolism" EXACT [GOC:TermGenie] +synonym: "copal-8-ol diphosphate(3-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "copal-8-ol diphosphate(3-) formation" EXACT [GOC:TermGenie] +synonym: "copal-8-ol diphosphate(3-) synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:1902241 ! copal-8-ol diphosphate(3-) metabolic process + +[Term] +id: GO:1902244 +name: cis-abienol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cis-abienol." [GOC:TermGenie, pmid:22672125] +synonym: "cis-abienol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016101 ! diterpenoid metabolic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:1902245 +name: cis-abienol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cis-abienol." [GOC:TermGenie, pmid:22672125] +synonym: "cis-abienol breakdown" EXACT [GOC:TermGenie] +synonym: "cis-abienol catabolism" EXACT [GOC:TermGenie] +synonym: "cis-abienol degradation" EXACT [GOC:TermGenie] +is_a: GO:0016103 ! diterpenoid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1902244 ! cis-abienol metabolic process + +[Term] +id: GO:1902246 +name: cis-abienol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cis-abienol." [GOC:TermGenie, pmid:22672125] +synonym: "cis-abienol anabolism" EXACT [GOC:TermGenie] +synonym: "cis-abienol biosynthesis" EXACT [GOC:TermGenie] +synonym: "cis-abienol formation" EXACT [GOC:TermGenie] +synonym: "cis-abienol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016102 ! diterpenoid biosynthetic process +is_a: GO:1902244 ! cis-abienol metabolic process +is_a: GO:1902645 ! tertiary alcohol biosynthetic process + +[Term] +id: GO:1902247 +name: geranylgeranyl diphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of geranylgeranyl diphosphate." [GOC:TermGenie, pmid:22672125] +synonym: "geranylgeranyl diphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "geranylgeranyl diphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "geranylgeranyl diphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0016115 ! terpenoid catabolic process +is_a: GO:0033385 ! geranylgeranyl diphosphate metabolic process + +[Term] +id: GO:1902248 +name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding +namespace: molecular_function +def: "Binding to 5-O-phosphono-alpha-D-ribofuranosyl diphosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] +synonym: "5-phosphoribose 1-diphosphate binding" EXACT [] +synonym: "phosphoribosylpyrophosphate binding" EXACT [GOC:al] +is_a: GO:0043168 ! anion binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:1902249 +name: IMP binding +namespace: molecular_function +def: "Binding to IMP, inosine monophosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] +is_a: GO:0032555 ! purine ribonucleotide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:1902250 +name: regulation of erythrocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +relationship: regulates GO:1902217 ! erythrocyte apoptotic process + +[Term] +id: GO:1902251 +name: negative regulation of erythrocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "down regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of erythrocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of RBC apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of red blood cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process +is_a: GO:1902250 ! regulation of erythrocyte apoptotic process +relationship: negatively_regulates GO:1902217 ! erythrocyte apoptotic process + +[Term] +id: GO:1902252 +name: positive regulation of erythrocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:14569084] +synonym: "activation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of erythrocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of RBC apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of red blood cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of erythrocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of erythrocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of RBC apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of RBC apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of red blood cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of red blood cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process +is_a: GO:1902250 ! regulation of erythrocyte apoptotic process +relationship: positively_regulates GO:1902217 ! erythrocyte apoptotic process + +[Term] +id: GO:1902253 +name: regulation of intrinsic apoptotic signaling pathway by p53 class mediator +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] +synonym: "regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1901796 ! regulation of signal transduction by p53 class mediator +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator + +[Term] +id: GO:1902254 +name: negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] +synonym: "down regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "down-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "downregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "inhibition of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "negative regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1901797 ! negative regulation of signal transduction by p53 class mediator +is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator + +[Term] +id: GO:1902255 +name: positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, GOC:TermGenie, PMID:15705871] +synonym: "activation of intrinsic apoptotic signaling pathway by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" NARROW [GOC:TermGenie] +synonym: "activation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "positive regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "up-regulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator" EXACT [GOC:TermGenie] +synonym: "upregulation of signal transduction by p53 class mediator resulting in induction of apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1901798 ! positive regulation of signal transduction by p53 class mediator +is_a: GO:1902253 ! regulation of intrinsic apoptotic signaling pathway by p53 class mediator +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator + +[Term] +id: GO:1902256 +name: regulation of apoptotic process involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] +synonym: "regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis +relationship: regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis + +[Term] +id: GO:1902257 +name: negative regulation of apoptotic process involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] +synonym: "down regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis +is_a: GO:1902338 ! negative regulation of apoptotic process involved in morphogenesis +relationship: negatively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis + +[Term] +id: GO:1902258 +name: positive regulation of apoptotic process involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16839542] +synonym: "activation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptosis involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:1902256 ! regulation of apoptotic process involved in outflow tract morphogenesis +is_a: GO:1902339 ! positive regulation of apoptotic process involved in morphogenesis +relationship: positively_regulates GO:0003275 ! apoptotic process involved in outflow tract morphogenesis + +[Term] +id: GO:1902259 +name: regulation of delayed rectifier potassium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204] +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1902260 +name: negative regulation of delayed rectifier potassium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11299204] +synonym: "down regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie] +is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity +is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity + +[Term] +id: GO:1902261 +name: positive regulation of delayed rectifier potassium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204] +synonym: "activation of delayed rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of delayed rectifier potassium channel activity" EXACT [GOC:TermGenie] +is_a: GO:1902259 ! regulation of delayed rectifier potassium channel activity +is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity + +[Term] +id: GO:1902262 +name: apoptotic process involved in blood vessel morphogenesis +namespace: biological_process +def: "Any apoptotic process that is involved in blood vessel morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:16163358] +synonym: "apoptosis involved in patterning of blood vessels" NARROW [GOC:TermGenie] +synonym: "apoptotic cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "apoptotic program involved in patterning of blood vessels" NARROW [GOC:TermGenie] +synonym: "apoptotic programmed cell death involved in patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "programmed cell death by apoptosis involved in patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity involved in patterning of blood vessels" RELATED [GOC:TermGenie] +synonym: "type I programmed cell death involved in patterning of blood vessels" NARROW [GOC:TermGenie] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +relationship: part_of GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:1902263 +name: apoptotic process involved in embryonic digit morphogenesis +namespace: biological_process +def: "Any apoptotic process that is involved in embryonic digit morphogenesis." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:15967824] +synonym: "apoptosis involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] +synonym: "apoptotic cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] +synonym: "apoptotic program involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] +synonym: "apoptotic programmed cell death involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] +synonym: "programmed cell death by apoptosis involved in embryonic digit morphogenesis" EXACT [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity involved in embryonic digit morphogenesis" RELATED [GOC:TermGenie] +synonym: "type I programmed cell death involved in embryonic digit morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +relationship: part_of GO:0042733 ! embryonic digit morphogenesis + +[Term] +id: GO:1902265 +name: abscisic acid homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of abscisic acid within an organism or cell." [GOC:TermGenie, PMID:23252460] +synonym: "2-cis-abscisate homeostasis" RELATED [] +synonym: "ABA homeostasis" RELATED [] +is_a: GO:0055081 ! anion homeostasis +is_a: GO:0055088 ! lipid homeostasis + +[Term] +id: GO:1902266 +name: cellular abscisic acid homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of abscisic acid at the level of the cell." [GOC:TermGenie, PMID:23252460] +synonym: "cellular 2-cis-abscisate homeostasis" EXACT [] +synonym: "cellular ABA homeostasis" RELATED [] +is_a: GO:0030002 ! cellular anion homeostasis +is_a: GO:1902265 ! abscisic acid homeostasis + +[Term] +id: GO:1902267 +name: regulation of polyamine transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] +is_a: GO:0034762 ! regulation of transmembrane transport +relationship: regulates GO:1902047 ! polyamine transmembrane transport + +[Term] +id: GO:1902268 +name: negative regulation of polyamine transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] +synonym: "down regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of polyamine transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:1902267 ! regulation of polyamine transmembrane transport +relationship: negatively_regulates GO:1902047 ! polyamine transmembrane transport + +[Term] +id: GO:1902269 +name: positive regulation of polyamine transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of polyamine transmembrane transport." [GOC:TermGenie, PMID:23755272] +synonym: "activation of polyamine transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of polyamine transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:1902267 ! regulation of polyamine transmembrane transport +relationship: positively_regulates GO:1902047 ! polyamine transmembrane transport + +[Term] +id: GO:1902270 +name: (R)-carnitine transmembrane transport +namespace: biological_process +def: "The process in which (R)-carnitine is transported across a membrane." [GOC:TermGenie, PMID:23755272] +is_a: GO:1900749 ! (R)-carnitine transport +is_a: GO:1902603 ! carnitine transmembrane transport + +[Term] +id: GO:1902271 +name: D3 vitamins binding +namespace: molecular_function +def: "Binding to D3 vitamins." [GOC:bf, GOC:TermGenie, PMID:9127467] +is_a: GO:0005499 ! vitamin D binding + +[Term] +id: GO:1902272 +name: regulation of (R)-carnitine transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1902270 ! (R)-carnitine transmembrane transport + +[Term] +id: GO:1902273 +name: negative regulation of (R)-carnitine transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] +synonym: "down regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:1902270 ! (R)-carnitine transmembrane transport + +[Term] +id: GO:1902274 +name: positive regulation of (R)-carnitine transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of (R)-carnitine transmembrane transport." [GOC:TermGenie, PMID:23755272] +synonym: "activation of (R)-carnitine transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of (R)-carnitine transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:1902272 ! regulation of (R)-carnitine transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:1902270 ! (R)-carnitine transmembrane transport + +[Term] +id: GO:1902275 +name: regulation of chromatin organization +namespace: biological_process +alt_id: GO:1903308 +def: "Any process that modulates the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:bf, GOC:TermGenie, GOC:vw, PMID:18314879] +synonym: "regulation of chromatin modification" RELATED [] +synonym: "regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0006325 ! chromatin organization + +[Term] +id: GO:1902276 +name: regulation of pancreatic amylase secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie] +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0036395 ! pancreatic amylase secretion + +[Term] +id: GO:1902277 +name: negative regulation of pancreatic amylase secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie] +synonym: "down regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of pancreatic amylase secretion" NARROW [GOC:TermGenie] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:1902276 ! regulation of pancreatic amylase secretion +relationship: negatively_regulates GO:0036395 ! pancreatic amylase secretion + +[Term] +id: GO:1902278 +name: positive regulation of pancreatic amylase secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687] +synonym: "activation of pancreatic amylase secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic amylase secretion" EXACT [GOC:TermGenie] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:1902276 ! regulation of pancreatic amylase secretion +relationship: positively_regulates GO:0036395 ! pancreatic amylase secretion + +[Term] +id: GO:1902279 +name: positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway +namespace: biological_process +def: "A cholecystokinin signaling pathway that results in positive regulation of pancreatic amylase secretion." [GOC:jc, GOC:TermGenie, PMID:19028687] +synonym: "activation of pancreatic amylase secretion by cholecystokinin signaling pathway" NARROW [GOC:TermGenie] +synonym: "CCK-induced amylase release in pancreatic cell" EXACT [PMID:19028687] +synonym: "CCK-mediated pancreatic amylase secretion" EXACT [PMID:19028687] +synonym: "CCK-stimulated pancreatic amylase release" EXACT [PMID:19028687] +synonym: "cholecystokinin-mediated pancreatic amylase secretion" EXACT [PMID:19028687] +synonym: "up regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic amylase secretion by cholecystokinin signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0038188 ! cholecystokinin signaling pathway +is_a: GO:1902278 ! positive regulation of pancreatic amylase secretion + +[Term] +id: GO:1902280 +name: regulation of RNA helicase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653] +synonym: "regulation of ATP-dependent RNA helicase activity" EXACT [] +is_a: GO:0051095 ! regulation of helicase activity + +[Term] +id: GO:1902281 +name: negative regulation of RNA helicase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:23721653] +synonym: "down regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP-dependent RNA helicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ATP-dependent RNA helicase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP-dependent RNA helicase activity" EXACT [] +is_a: GO:0051097 ! negative regulation of helicase activity +is_a: GO:1902280 ! regulation of RNA helicase activity + +[Term] +id: GO:1902282 +name: voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +namespace: molecular_function +def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244] +synonym: "voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0086008 ! voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization + +[Term] +id: GO:1902283 +name: negative regulation of primary amine oxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary amine oxidase activity." [GOC:TermGenie, PMID:23349812] +synonym: "down regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] +synonym: "down regulation of primary amine oxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of primary amine oxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] +synonym: "downregulation of primary amine oxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] +synonym: "inhibition of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of primary amine oxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of primary-amine:oxygen oxidoreductase (deaminating) activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of amine oxidase (copper-containing) activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity + +[Term] +id: GO:1902284 +name: neuron projection extension involved in neuron projection guidance +namespace: biological_process +def: "Any neuron projection extension that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] +synonym: "neurite extension involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "neurite extension involved in neuron process guidance" NARROW [GOC:TermGenie] +synonym: "neurite extension involved in neuron projection guidance" NARROW [GOC:TermGenie] +synonym: "neurite extension involved in neuron protrusion guidance" NARROW [GOC:TermGenie] +synonym: "neurite extension involved in neuronal cell projection guidance" NARROW [GOC:TermGenie] +synonym: "neuron process extension involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "neuron process extension involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "neuron process extension involved in neuron projection guidance" EXACT [GOC:TermGenie] +synonym: "neuron process extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "neuron process extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +synonym: "neuron projection extension involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "neuron projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "neuron projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "neuron projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +synonym: "neuron protrusion extension involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "neuron protrusion extension involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "neuron protrusion extension involved in neuron projection guidance" EXACT [GOC:TermGenie] +synonym: "neuron protrusion extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "neuron protrusion extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +synonym: "neuronal cell projection extension involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "neuronal cell projection extension involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "neuronal cell projection extension involved in neuron projection guidance" EXACT [GOC:TermGenie] +synonym: "neuronal cell projection extension involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "neuronal cell projection extension involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +is_a: GO:1990138 ! neuron projection extension +relationship: part_of GO:0097485 ! neuron projection guidance + +[Term] +id: GO:1902285 +name: semaphorin-plexin signaling pathway involved in neuron projection guidance +namespace: biological_process +def: "Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] +synonym: "semaphorin-plexin signaling pathway involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in neurite guidance" NARROW [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in neuron process guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in neuron projection guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in neuron protrusion guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in neuronal cell projection guidance" EXACT [GOC:TermGenie] +is_a: GO:0071526 ! semaphorin-plexin signaling pathway +relationship: part_of GO:0097485 ! neuron projection guidance + +[Term] +id: GO:1902286 +name: semaphorin-plexin signaling pathway involved in dendrite guidance +namespace: biological_process +def: "Any semaphorin-plexin signaling pathway that is involved in dendrite guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] +synonym: "semaphorin-plexin signaling pathway involved in dendritic guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in dendrite guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in dendritic guidance" EXACT [GOC:TermGenie] +is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance +relationship: part_of GO:0070983 ! dendrite guidance + +[Term] +id: GO:1902287 +name: semaphorin-plexin signaling pathway involved in axon guidance +namespace: biological_process +def: "Any semaphorin-plexin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22790009] +synonym: "semaphorin-plexin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "semaphorin-plexin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in axon guidance" EXACT [GOC:TermGenie] +synonym: "semaphorin-plexin signalling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902285 ! semaphorin-plexin signaling pathway involved in neuron projection guidance +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:1902288 +name: regulation of defense response to oomycetes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0002229 ! defense response to oomycetes + +[Term] +id: GO:1902289 +name: negative regulation of defense response to oomycetes +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] +synonym: "down regulation of defense response to oomycetes" EXACT [GOC:TermGenie] +synonym: "down-regulation of defense response to oomycetes" EXACT [GOC:TermGenie] +synonym: "downregulation of defense response to oomycetes" EXACT [GOC:TermGenie] +synonym: "inhibition of defense response to oomycetes" NARROW [GOC:TermGenie] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1902288 ! regulation of defense response to oomycetes +relationship: negatively_regulates GO:0002229 ! defense response to oomycetes + +[Term] +id: GO:1902290 +name: positive regulation of defense response to oomycetes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of defense response to oomycetes." [GOC:TermGenie, PMID:16040633] +synonym: "activation of defense response to oomycetes" NARROW [GOC:TermGenie] +synonym: "up regulation of defense response to oomycetes" EXACT [GOC:TermGenie] +synonym: "up-regulation of defense response to oomycetes" EXACT [GOC:TermGenie] +synonym: "upregulation of defense response to oomycetes" EXACT [GOC:TermGenie] +is_a: GO:0002833 ! positive regulation of response to biotic stimulus +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1902288 ! regulation of defense response to oomycetes +relationship: positively_regulates GO:0002229 ! defense response to oomycetes + +[Term] +id: GO:1902291 +name: cell cycle DNA replication DNA ligation +namespace: biological_process +def: "Any DNA ligation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA ligation involved in cell cycle DNA replication" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0051104 ! DNA-dependent DNA replication DNA ligation +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902292 +name: cell cycle DNA replication initiation +namespace: biological_process +def: "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA endoreduplication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA re-replication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA replication initiation involved in cell cycle DNA replication" EXACT [] +synonym: "DNA-dependent DNA replication initiation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] +is_a: GO:0006270 ! DNA replication initiation +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902294 +name: cell cycle DNA replication termination +namespace: biological_process +def: "Any DNA replication termination that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication termination involved in cell cycle DNA replication" EXACT [] +is_a: GO:0006274 ! DNA replication termination +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902295 +name: synthesis of RNA primer involved in cell cycle DNA replication +namespace: biological_process +def: "Any DNA replication, synthesis of RNA primer that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication, synthesis of RNA primer involved in cell cycle DNA replication" EXACT [] +synonym: "replication priming involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +is_a: GO:0006269 ! DNA replication, synthesis of RNA primer +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902296 +name: DNA strand elongation involved in cell cycle DNA replication +namespace: biological_process +def: "Any DNA strand elongation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication elongation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA strand elongation during DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +is_a: GO:0006271 ! DNA strand elongation involved in DNA replication +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902297 +name: cell cycle DNA replication DNA unwinding +namespace: biological_process +def: "Any DNA unwinding that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA unwinding during replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +synonym: "DNA unwinding factor involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +synonym: "DNA unwinding involved in cell cycle DNA replication" EXACT [] +is_a: GO:0006268 ! DNA unwinding involved in DNA replication +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902298 +name: cell cycle DNA replication maintenance of fidelity +namespace: biological_process +def: "Any maintenance of fidelity that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +synonym: "maintenance of fidelity involved in cell cycle DNA replication" EXACT [] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902299 +name: pre-replicative complex assembly involved in cell cycle DNA replication +namespace: biological_process +def: "Any pre-replicative complex assembly that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "pre-RC assembly involved in cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "pre-replication complex assembly involved in cell cycle DNA replication" RELATED [GOC:TermGenie] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0036388 ! pre-replicative complex assembly +relationship: part_of GO:0044786 ! cell cycle DNA replication + +[Term] +id: GO:1902300 +name: galactarate transmembrane transport +namespace: biological_process +alt_id: GO:0042871 +def: "The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "D-galactarate transport" RELATED [] +synonym: "galactarate transport" RELATED [] +synonym: "galactaric acid anion transport" EXACT [] +is_a: GO:0042869 ! aldarate transmembrane transport + +[Term] +id: GO:1902301 +name: galactarate transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0042877 +def: "Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other." [GOC:pr, GOC:TermGenie] +synonym: "D-galactarate transmembrane transporter activity" RELATED [] +synonym: "galactaric acid anion transmembrane transporter activity" EXACT [] +is_a: GO:0042876 ! aldarate transmembrane transporter activity + +[Term] +id: GO:1902305 +name: regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0002028 ! regulation of sodium ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0035725 ! sodium ion transmembrane transport + +[Term] +id: GO:1902306 +name: negative regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "down regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of sodium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0010766 ! negative regulation of sodium ion transport +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0035725 ! sodium ion transmembrane transport + +[Term] +id: GO:1902307 +name: positive regulation of sodium ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18591664] +synonym: "activation of sodium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of sodium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium ion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0010765 ! positive regulation of sodium ion transport +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0035725 ! sodium ion transmembrane transport + +[Term] +id: GO:1902308 +name: regulation of peptidyl-serine dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] +is_a: GO:0035304 ! regulation of protein dephosphorylation +relationship: regulates GO:0070262 ! peptidyl-serine dephosphorylation + +[Term] +id: GO:1902309 +name: negative regulation of peptidyl-serine dephosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] +synonym: "down regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie] +is_a: GO:0035308 ! negative regulation of protein dephosphorylation +is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation +relationship: negatively_regulates GO:0070262 ! peptidyl-serine dephosphorylation + +[Term] +id: GO:1902310 +name: positive regulation of peptidyl-serine dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptidyl-serine dephosphorylation." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:11953308] +synonym: "activation of peptidyl-serine dephosphorylation" NARROW [GOC:TermGenie] +synonym: "up regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-serine dephosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0035307 ! positive regulation of protein dephosphorylation +is_a: GO:1902308 ! regulation of peptidyl-serine dephosphorylation +relationship: positively_regulates GO:0070262 ! peptidyl-serine dephosphorylation + +[Term] +id: GO:1902311 +name: regulation of copper ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] +synonym: "regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0010959 ! regulation of metal ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0035434 ! copper ion transmembrane transport + +[Term] +id: GO:1902312 +name: negative regulation of copper ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] +synonym: "down regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of copper cation transmembrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of copper ion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of copper ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "negative regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +is_a: GO:1902311 ! regulation of copper ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0035434 ! copper ion transmembrane transport + +[Term] +id: GO:1902313 +name: positive regulation of copper ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of copper ion transmembrane transport." [GOC:di, GOC:TermGenie, PMID:21489137] +synonym: "activation of copper cation transmembrane transport" NARROW [GOC:TermGenie] +synonym: "activation of copper ion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of copper ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of copper cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of copper ion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of copper ion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:1902311 ! regulation of copper ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0035434 ! copper ion transmembrane transport + +[Term] +id: GO:1902314 +name: hydroquinone binding +namespace: molecular_function +def: "Binding to hydroquinone." [GOC:bhm, GOC:TermGenie, pmid:15667223] +synonym: "quinol binding" EXACT [] +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:1902315 +name: nuclear cell cycle DNA replication initiation +namespace: biological_process +def: "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA re-replication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA replication initiation involved in nuclear cell cycle DNA replication" EXACT [] +is_a: GO:1902292 ! cell cycle DNA replication initiation +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902317 +name: nuclear DNA replication termination +namespace: biological_process +def: "Any DNA replication termination that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication termination involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA replication termination involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA replication termination involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "DNA replication termination involved in nuclear cell cycle DNA replication" EXACT [] +is_a: GO:1902294 ! cell cycle DNA replication termination +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902318 +name: synthesis of RNA primer involved in nuclear cell cycle DNA replication +namespace: biological_process +def: "Any synthesis of RNA primer that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication, synthesis of RNA primer involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA replication, synthesis of RNA primer involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "replication priming involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "replication priming involved in DNA replication involved in S phase" RELATED [GOC:TermGenie] +synonym: "replication priming involved in DNA replication involved in S-phase" RELATED [GOC:TermGenie] +synonym: "replication priming involved in nuclear cell cycle DNA replication" RELATED [GOC:TermGenie] +is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902319 +name: DNA strand elongation involved in nuclear cell cycle DNA replication +namespace: biological_process +def: "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA strand elongation involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA strand elongation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA strand elongation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902320 +name: nuclear DNA replication DNA duplex unwinding +namespace: biological_process +def: "Any DNA duplex unwinding that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA duplex unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA duplex unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA duplex unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "DNA duplex unwinding involved in nuclear cell cycle DNA replication" EXACT [] +synonym: "DNA unwinding involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA unwinding involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA unwinding involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "DNA unwinding involved in nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "duplex DNA melting involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "duplex DNA melting involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "duplex DNA melting involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902321 +name: methyl-branched fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methyl-branched fatty acid." [GOC:kmv, GOC:TermGenie, PMID:15340492] +synonym: "methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:0097089 ! methyl-branched fatty acid metabolic process + +[Term] +id: GO:1902322 +name: regulation of methyl-branched fatty acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] +synonym: "regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process + +[Term] +id: GO:1902323 +name: negative regulation of methyl-branched fatty acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] +synonym: "down regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of methyl-branched fatty acid formation" NARROW [GOC:TermGenie] +synonym: "inhibition of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process +relationship: negatively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process + +[Term] +id: GO:1902324 +name: positive regulation of methyl-branched fatty acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methyl-branched fatty acid biosynthetic process." [GOC:kmv, GOC:TermGenie, PMID:15340492] +synonym: "activation of methyl-branched fatty acid anabolism" NARROW [GOC:TermGenie] +synonym: "activation of methyl-branched fatty acid biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of methyl-branched fatty acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of methyl-branched fatty acid formation" NARROW [GOC:TermGenie] +synonym: "activation of methyl-branched fatty acid synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of methyl-branched fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of methyl-branched fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of methyl-branched fatty acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of methyl-branched fatty acid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of methyl-branched fatty acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1902322 ! regulation of methyl-branched fatty acid biosynthetic process +relationship: positively_regulates GO:1902321 ! methyl-branched fatty acid biosynthetic process + +[Term] +id: GO:1902325 +name: negative regulation of chlorophyll biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952] +synonym: "down regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chlorophyll anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll formation" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process +is_a: GO:1901464 ! negative regulation of tetrapyrrole biosynthetic process +relationship: negatively_regulates GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:1902326 +name: positive regulation of chlorophyll biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chlorophyll biosynthetic process." [GOC:TermGenie, PMID:23555952] +synonym: "activation of chlorophyll anabolism" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll formation" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll formation" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010380 ! regulation of chlorophyll biosynthetic process +is_a: GO:1901465 ! positive regulation of tetrapyrrole biosynthetic process +relationship: positively_regulates GO:0015995 ! chlorophyll biosynthetic process + +[Term] +id: GO:1902327 +name: bacterial-type DNA replication DNA ligation +namespace: biological_process +def: "Any DNA ligation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA ligation involved in bacterial-type DNA replication" EXACT [] +is_a: GO:1902291 ! cell cycle DNA replication DNA ligation +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:1902328 +name: bacterial-type DNA replication initiation +namespace: biological_process +def: "Any DNA replication initiation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA endoreduplication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA re-replication initiation involved in bacterial-type DNA replication" NARROW [GOC:TermGenie] +synonym: "DNA replication initiation involved in bacterial-type DNA replication" EXACT [] +synonym: "DNA-dependent DNA replication initiation involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] +is_a: GO:1902292 ! cell cycle DNA replication initiation +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:1902329 +name: bacterial-type DNA replication termination +namespace: biological_process +def: "Any DNA replication termination that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA replication termination involved in bacterial-type DNA replication" EXACT [] +is_a: GO:1902294 ! cell cycle DNA replication termination +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:1902330 +name: synthesis of RNA primer involved in bacterial-type DNA replication +namespace: biological_process +def: "Any synthesis of RNA primer that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "replication priming involved in bacterial-type DNA replication" RELATED [GOC:TermGenie] +is_a: GO:1902295 ! synthesis of RNA primer involved in cell cycle DNA replication +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:1902331 +name: obsolete DNA strand elongation involved in bacterial-type DNA replication +namespace: biological_process +def: "OBSOLETE. Any DNA strand elongation that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it does not represent a distinct function from its parent, DNA strand elongation involved in DNA replication. +is_obsolete: true + +[Term] +id: GO:1902332 +name: bacterial-type DNA replication DNA duplex unwinding +namespace: biological_process +def: "Any DNA duplex unwinding that is involved in bacterial-type DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA duplex unwinding involved in bacterial-type DNA replication" EXACT [] +synonym: "DNA unwinding involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] +synonym: "duplex DNA melting involved in bacterial-type DNA replication" EXACT [GOC:TermGenie] +is_a: GO:1902297 ! cell cycle DNA replication DNA unwinding +relationship: part_of GO:0044787 ! bacterial-type DNA replication + +[Term] +id: GO:1902333 +name: nuclear DNA replication DNA ligation +namespace: biological_process +def: "Any DNA ligation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "DNA ligation involved in DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "DNA ligation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "DNA ligation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "DNA ligation involved in nuclear cell cycle DNA replication" EXACT [] +is_a: GO:1902291 ! cell cycle DNA replication DNA ligation +relationship: part_of GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902334 +name: fructose export from vacuole to cytoplasm +namespace: biological_process +def: "The directed movement of fructose from vacuole to cytoplasm." [GOC:TermGenie, PMID:23583552] +synonym: "fructose transport from vacuole to cytoplasm" EXACT [] +is_a: GO:0015755 ! fructose transmembrane transport +is_a: GO:0033231 ! carbohydrate export +is_a: GO:0034486 ! vacuolar transmembrane transport + +[Term] +id: GO:1902335 +name: obsolete positive chemotaxis involved in neuron migration +namespace: biological_process +def: "OBSOLETE. Any positive chemotaxis that is involved in neuron migration." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "chemoattraction involved in neuron chemotaxis" EXACT [GOC:TermGenie] +synonym: "chemoattraction involved in neuron guidance" RELATED [GOC:TermGenie] +synonym: "chemoattraction involved in neuron migration" EXACT [GOC:TermGenie] +synonym: "chemoattraction involved in neuronal migration" EXACT [GOC:TermGenie] +synonym: "positive chemotaxis involved in neuron chemotaxis" EXACT [GOC:TermGenie] +synonym: "positive chemotaxis involved in neuron guidance" RELATED [GOC:TermGenie] +synonym: "positive chemotaxis involved in neuron migration" EXACT [] +synonym: "positive chemotaxis involved in neuronal migration" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902336 +name: positive regulation of retinal ganglion cell axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] +synonym: "activation of retinal ganglion cell axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of retinal ganglion cell axon pathfinding" NARROW [GOC:TermGenie] +synonym: "positive regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] +synonym: "upregulation of retinal ganglion cell axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of retinal ganglion cell axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0090259 ! regulation of retinal ganglion cell axon guidance +is_a: GO:1902669 ! positive regulation of axon guidance +relationship: positively_regulates GO:0031290 ! retinal ganglion cell axon guidance + +[Term] +id: GO:1902337 +name: regulation of apoptotic process involved in morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] +synonym: "regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: regulates GO:0060561 ! apoptotic process involved in morphogenesis + +[Term] +id: GO:1902338 +name: negative regulation of apoptotic process involved in morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] +synonym: "down regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "down regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "down-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "downregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "inhibition of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "negative regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis +is_a: GO:1904746 ! negative regulation of apoptotic process involved in development +relationship: negatively_regulates GO:0060561 ! apoptotic process involved in morphogenesis + +[Term] +id: GO:1902339 +name: positive regulation of apoptotic process involved in morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis." [GOC:sart, GOC:TermGenie, PMID:12202035] +synonym: "activation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "activation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "positive regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "up regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "up-regulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +synonym: "upregulation of apoptosis involved in development" RELATED [GOC:TermGenie] +synonym: "upregulation of apoptosis involved in morphogenesis" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of morphogenetic apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1902337 ! regulation of apoptotic process involved in morphogenesis +is_a: GO:1904747 ! positive regulation of apoptotic process involved in development +relationship: positively_regulates GO:0060561 ! apoptotic process involved in morphogenesis + +[Term] +id: GO:1902340 +name: negative regulation of chromosome condensation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation." [GOC:TermGenie, PMID:23219725] +synonym: "down regulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "down regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "down-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "downregulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "downregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "inhibition of chromosome condensation" NARROW [GOC:TermGenie] +synonym: "inhibition of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear chromosome condensation" NARROW [GOC:TermGenie] +synonym: "negative regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "negative regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +is_a: GO:0060623 ! regulation of chromosome condensation +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0030261 ! chromosome condensation + +[Term] +id: GO:1902341 +name: xylitol transport +namespace: biological_process +def: "The directed movement of a xylitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xylitol is a polyalcohol (pentane-1,2,3,4,5-pentol), produced by hydrogenation of xylose." [GOC:TermGenie, PMID:23475614] +is_a: GO:0008643 ! carbohydrate transport +is_a: GO:0015791 ! polyol transport + +[Term] +id: GO:1902342 +name: xylitol export +namespace: biological_process +def: "The directed movement of xylitol out of a cell or organelle." [GOC:TermGenie, PMID:23475614] +is_a: GO:0033231 ! carbohydrate export +is_a: GO:1902341 ! xylitol transport + +[Term] +id: GO:1902343 +name: regulation of maltose transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0015768 ! maltose transport + +[Term] +id: GO:1902344 +name: negative regulation of maltose transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] +synonym: "down regulation of maltose transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of maltose transport" EXACT [GOC:TermGenie] +synonym: "downregulation of maltose transport" EXACT [GOC:TermGenie] +synonym: "inhibition of maltose transport" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1902343 ! regulation of maltose transport +relationship: negatively_regulates GO:0015768 ! maltose transport + +[Term] +id: GO:1902345 +name: positive regulation of maltose transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maltose transport." [GOC:dph, GOC:TermGenie, PMID:23770568] +synonym: "activation of maltose transport" NARROW [GOC:TermGenie] +synonym: "up regulation of maltose transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of maltose transport" EXACT [GOC:TermGenie] +synonym: "upregulation of maltose transport" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1902343 ! regulation of maltose transport +relationship: positively_regulates GO:0015768 ! maltose transport + +[Term] +id: GO:1902346 +name: meiotic strand displacement involved in double-strand break repair via SDSA +namespace: biological_process +def: "Any meiotic strand displacement that is involved in double-strand break repair via synthesis-dependent strand annealing (SDSA)." [GOC:al, GOC:TermGenie, PMID:22723423] +synonym: "meiotic D-loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] +synonym: "meiotic D-loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie] +synonym: "meiotic D-loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] +synonym: "meiotic D-loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie] +synonym: "meiotic displacement loop dissociation involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] +synonym: "meiotic displacement loop dissociation involved in mitotic gene conversion" RELATED [GOC:TermGenie] +synonym: "meiotic displacement loop processing involved in double-strand break repair via synthesis-dependent strand annealing" RELATED [GOC:TermGenie] +synonym: "meiotic displacement loop processing involved in mitotic gene conversion" RELATED [GOC:TermGenie] +synonym: "meiotic strand displacement involved in double-strand break repair via synthesis-dependent strand annealing" EXACT [] +synonym: "meiotic strand displacement involved in mitotic gene conversion" RELATED [GOC:TermGenie] +synonym: "meiotic strand displacement involved in SDSA" BROAD [] +is_a: GO:0000714 ! meiotic strand displacement +relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing + +[Term] +id: GO:1902347 +name: response to strigolactone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] +synonym: "response to strigolactone analog GR24" RELATED [PMID:23893171] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1902348 +name: cellular response to strigolactone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." [GOC:TermGenie, PMID:23893171] +synonym: "cellular response to strigolactone analog GR24" RELATED [PMID:23893171] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902347 ! response to strigolactone + +[Term] +id: GO:1902349 +name: response to chloroquine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1902350 +name: cellular response to chloroquine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloroquine stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1902349 ! response to chloroquine + +[Term] +id: GO:1902351 +name: response to imidacloprid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an imidacloprid stimulus." [GOC:kmv, GOC:TermGenie, PMID:23922869] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1902352 +name: obsolete negative regulation of filamentous growth of a population of unicellular organisms in response to starvation by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GOC:rn, GOC:TermGenie, PMID:23223039] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1902353 +name: obsolete positive regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter by pheromones that results in positive regulation of induction of conjugation with cellular fusion." [GOC:rn, GOC:TermGenie, PMID:23872066] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "up regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] +synonym: "up-regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] +synonym: "upregulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902354 +name: blood vessel endothelial cell delamination involved in blood vessel lumen ensheathment +namespace: biological_process +def: "Any blood vessel endothelial cell delamination that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350] +is_a: GO:0097497 ! blood vessel endothelial cell delamination +relationship: part_of GO:0097496 ! blood vessel lumen ensheathment + +[Term] +id: GO:1902355 +name: endothelial tube lumen extension involved in blood vessel lumen ensheathment +namespace: biological_process +def: "Any endothelial tube lumen extension that is involved in blood vessel lumen ensheathment." [GOC:dgh, GOC:TermGenie, PMID:23698350] +is_a: GO:0097498 ! endothelial tube lumen extension +relationship: part_of GO:0097496 ! blood vessel lumen ensheathment + +[Term] +id: GO:1902356 +name: oxaloacetate(2-) transmembrane transport +namespace: biological_process +def: "The directed movement of oxaloacetate(2-) across a membrane." [GOC:dph, GOC:TermGenie, PMID:18682385] +is_a: GO:0015729 ! oxaloacetate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1902357 +name: 2-isopropylmalate(2-) transmembrane transport +namespace: biological_process +def: "The process in which 2-isopropylmalate(2-) is transported across a membrane." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:18682385] +is_a: GO:0034659 ! isopropylmalate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1902358 +name: sulfate transmembrane transport +namespace: biological_process +def: "The directed movement of sulfate across a membrane." [GOC:dph, GOC:TermGenie, PMID:9055073] +is_a: GO:0008272 ! sulfate transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1902359 +name: Notch signaling pathway involved in somitogenesis +namespace: biological_process +def: "Any Notch signaling pathway that is involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] +synonym: "N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:0001756 ! somitogenesis + +[Term] +id: GO:1902360 +name: obsolete conversion of ds siRNA to ss siRNA involved in gene silencing by small RNA +namespace: biological_process +def: "OBSOLETE. Any conversion of ds siRNA to ss siRNA that is involved in gene silencing by small RNA." [GOC:TermGenie, GOC:vw, PMID:19239886] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in chromatin silencing by small RNA" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA interference-like chromatin silencing" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated chromatin silencing" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNA-mediated transcriptional silencing" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-directed chromatin silencing" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in RNAi-like chromatin silencing" RELATED [GOC:TermGenie] +synonym: "conversion of double-stranded small interfering RNA to single-stranded small interfering RNA involved in small RNA-mediated heterochromatic silencing" RELATED [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in chromatin silencing by small RNA" EXACT [] +synonym: "conversion of ds siRNA to ss siRNA involved in RNA interference-like chromatin silencing" EXACT [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated chromatin silencing" EXACT [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in RNA-mediated transcriptional silencing" EXACT [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-directed chromatin silencing" EXACT [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in RNAi-like chromatin silencing" EXACT [GOC:TermGenie] +synonym: "conversion of ds siRNA to ss siRNA involved in small RNA-mediated heterochromatic silencing" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0004521 +consider: GO:0031047 + +[Term] +id: GO:1902362 +name: melanocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a melanocyte, the main structural component of the epidermis." [GOC:ic, GOC:TermGenie, PMID:20530876] +synonym: "melanocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "melanophore apoptosis" NARROW [GOC:TermGenie] +synonym: "melanophore apoptotic process" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1902363 +name: regulation of protein localization to spindle pole body +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] +synonym: "regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:1902364 +name: negative regulation of protein localization to spindle pole body +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] +synonym: "down regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to spindle pole body" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to spindle pole body" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1902363 ! regulation of protein localization to spindle pole body +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:1902365 +name: positive regulation of protein localization to spindle pole body +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to spindle pole body." [GOC:TermGenie, PMID:21131906] +synonym: "activation of protein localisation to spindle pole body" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to spindle pole body" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to spindle pole body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1902363 ! regulation of protein localization to spindle pole body +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:1902366 +name: regulation of Notch signaling pathway involved in somitogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] +synonym: "regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +is_a: GO:0008593 ! regulation of Notch signaling pathway +relationship: regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis + +[Term] +id: GO:1902367 +name: negative regulation of Notch signaling pathway involved in somitogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Notch signaling pathway involved in somitogenesis." [GOC:dph, GOC:TermGenie, PMID:21795391] +synonym: "down regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "down-regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "downregulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of N signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of N signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of N signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of N signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch-receptor signaling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch-receptor signaling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch-receptor signalling pathway involved in formation of mesodermal clusters" NARROW [GOC:TermGenie] +synonym: "inhibition of Notch-receptor signalling pathway involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of N signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of N signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of N signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of N signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch-receptor signaling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch-receptor signaling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch-receptor signalling pathway involved in formation of mesodermal clusters" EXACT [GOC:TermGenie] +synonym: "negative regulation of Notch-receptor signalling pathway involved in somitogenesis" EXACT [GOC:TermGenie] +is_a: GO:0045746 ! negative regulation of Notch signaling pathway +is_a: GO:1902366 ! regulation of Notch signaling pathway involved in somitogenesis +relationship: negatively_regulates GO:1902359 ! Notch signaling pathway involved in somitogenesis + +[Term] +id: GO:1902369 +name: negative regulation of RNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:16640457] +synonym: "down regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of RNA breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0051253 ! negative regulation of RNA metabolic process +relationship: negatively_regulates GO:0006401 ! RNA catabolic process + +[Term] +id: GO:1902370 +name: regulation of tRNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie] +synonym: "regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of tRNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:1903326 ! regulation of tRNA metabolic process +relationship: regulates GO:0016078 ! tRNA catabolic process + +[Term] +id: GO:1902371 +name: negative regulation of tRNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22919049] +synonym: "down regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of tRNA breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of tRNA catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tRNA catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of tRNA degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of tRNA degradation" EXACT [GOC:TermGenie] +is_a: GO:1902369 ! negative regulation of RNA catabolic process +is_a: GO:1902370 ! regulation of tRNA catabolic process +is_a: GO:1903327 ! negative regulation of tRNA metabolic process +relationship: negatively_regulates GO:0016078 ! tRNA catabolic process + +[Term] +id: GO:1902372 +name: positive regulation of tRNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA catabolic process." [GOC:bf, GOC:TermGenie] +synonym: "activation of tRNA breakdown" NARROW [GOC:TermGenie] +synonym: "activation of tRNA catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tRNA catabolism" NARROW [GOC:TermGenie] +synonym: "activation of tRNA degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:1902370 ! regulation of tRNA catabolic process +is_a: GO:1903328 ! positive regulation of tRNA metabolic process +relationship: positively_regulates GO:0016078 ! tRNA catabolic process + +[Term] +id: GO:1902373 +name: negative regulation of mRNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:22626865] +synonym: "down regulation of mRNA breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA decay" RELATED [GOC:TermGenie] +synonym: "down regulation of mRNA degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA decay" RELATED [GOC:TermGenie] +synonym: "down-regulation of mRNA degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA decay" RELATED [GOC:TermGenie] +synonym: "downregulation of mRNA degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of mRNA breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA decay" RELATED [GOC:TermGenie] +synonym: "inhibition of mRNA degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of mRNA breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA decay" RELATED [GOC:TermGenie] +synonym: "negative regulation of mRNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0061013 ! regulation of mRNA catabolic process +is_a: GO:1902369 ! negative regulation of RNA catabolic process +is_a: GO:1903312 ! negative regulation of mRNA metabolic process +relationship: negatively_regulates GO:0006402 ! mRNA catabolic process + +[Term] +id: GO:1902374 +name: regulation of rRNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rRNA catabolic process." [GOC:bf, GOC:TermGenie, PMID:20160119] +synonym: "regulation of rRNA breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of rRNA catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of rRNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0016075 ! rRNA catabolic process + +[Term] +id: GO:1902375 +name: nuclear tRNA 3'-trailer cleavage, endonucleolytic +namespace: biological_process +def: "Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus." [GOC:TermGenie, PMID:23928301] +synonym: "endonucleolytic tRNA 3'-end cleavage in cell nucleus" EXACT [GOC:TermGenie] +synonym: "endonucleolytic tRNA 3'-end cleavage in nucleus" EXACT [GOC:TermGenie] +synonym: "endonucleolytic tRNA 3'-trailer cleavage in cell nucleus" RELATED [GOC:TermGenie] +synonym: "endonucleolytic tRNA 3'-trailer cleavage in nucleus" RELATED [GOC:TermGenie] +synonym: "tRNA 3'-end cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie] +synonym: "tRNA 3'-end cleavage, endonucleolytic in nucleus" EXACT [GOC:TermGenie] +synonym: "tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus" EXACT [GOC:TermGenie] +is_a: GO:0034414 ! tRNA 3'-trailer cleavage, endonucleolytic + +[Term] +id: GO:1902376 +name: obsolete protein denaturation involved in proteasomal ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "OBSOLETE. Any protein denaturation that is involved in proteasomal ubiquitin-dependent protein catabolic process." [GOC:TermGenie, PMID:21091378] +comment: This term was made obsolete because it was poorly defined and the intended usage was unclear. +synonym: "protein denaturation involved in proteasomal pathway" EXACT [GOC:TermGenie] +synonym: "protein denaturation involved in proteasomal processing" RELATED [GOC:TermGenie] +synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein breakdown" EXACT [GOC:TermGenie] +synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein catabolism" EXACT [GOC:TermGenie] +synonym: "protein denaturation involved in proteasomal ubiquitin-dependent protein degradation" EXACT [GOC:TermGenie] +synonym: "protein denaturation involved in proteasome pathway" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902378 +name: VEGF-activated neuropilin signaling pathway involved in axon guidance +namespace: biological_process +def: "Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] +synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] +synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] +synonym: "vascular endothelial growth factor-activated neuropilin signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] +synonym: "VEGF-activated neuropilin signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "VEGF-activated neuropilin signaling pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "VEGF-activated neuropilin signaling pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "VEGF-Npn-1 signaling involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "VEGF-Npn-1 signaling involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "VEGF-Npn-1 signaling involved in axon guidance" NARROW [GOC:TermGenie] +synonym: "VEGF-Npn-1 signaling involved in axon pathfinding" NARROW [GOC:TermGenie] +is_a: GO:0038190 ! VEGF-activated neuropilin signaling pathway +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:1902379 +name: chemoattractant activity involved in axon guidance +namespace: molecular_function +def: "Any chemoattractant activity that is involved in axon guidance." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21658587] +synonym: "chemoattractant activity involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "chemoattractant activity involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "chemoattractant activity involved in axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0042056 ! chemoattractant activity + +[Term] +id: GO:1902380 +name: positive regulation of endoribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endoribonuclease activity." [GOC:bf, GOC:TermGenie] +synonym: "activation of endonuclease G activity" RELATED [GOC:TermGenie] +synonym: "activation of endoribonuclease activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of endonuclease G activity" RELATED [GOC:TermGenie] +synonym: "up regulation of endonuclease G activity" RELATED [GOC:TermGenie] +synonym: "up regulation of endoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of endonuclease G activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of endoribonuclease activity" EXACT [GOC:TermGenie] +synonym: "upregulation of endonuclease G activity" RELATED [GOC:TermGenie] +synonym: "upregulation of endoribonuclease activity" EXACT [GOC:TermGenie] +is_a: GO:0032075 ! positive regulation of nuclease activity +is_a: GO:0060699 ! regulation of endoribonuclease activity + +[Term] +id: GO:1902381 +name: 11-oxo-beta-amyrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] +synonym: "11-oxo-beta-amyrin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:1902382 +name: 11-oxo-beta-amyrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] +synonym: "11-oxo-beta-amyrin breakdown" EXACT [GOC:TermGenie] +synonym: "11-oxo-beta-amyrin catabolism" EXACT [GOC:TermGenie] +synonym: "11-oxo-beta-amyrin degradation" EXACT [GOC:TermGenie] +is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process + +[Term] +id: GO:1902383 +name: 11-oxo-beta-amyrin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 11-oxo-beta-amyrin." [GOC:TermGenie, pmid:22128119] +synonym: "11-oxo-beta-amyrin anabolism" EXACT [GOC:TermGenie] +synonym: "11-oxo-beta-amyrin biosynthesis" EXACT [GOC:TermGenie] +synonym: "11-oxo-beta-amyrin formation" EXACT [GOC:TermGenie] +synonym: "11-oxo-beta-amyrin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1902381 ! 11-oxo-beta-amyrin metabolic process + +[Term] +id: GO:1902384 +name: glycyrrhetinate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glycyrrhetinate." [GOC:TermGenie, pmid:22128119] +synonym: "glycyrrhetinate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1902385 +name: glycyrrhetinate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glycyrrhetinate." [GOC:TermGenie, pmid:22128119] +synonym: "glycyrrhetinate breakdown" EXACT [GOC:TermGenie] +synonym: "glycyrrhetinate catabolism" EXACT [GOC:TermGenie] +synonym: "glycyrrhetinate degradation" EXACT [GOC:TermGenie] +is_a: GO:0019741 ! pentacyclic triterpenoid catabolic process +is_a: GO:0042182 ! ketone catabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process +is_a: GO:1902384 ! glycyrrhetinate metabolic process + +[Term] +id: GO:1902386 +name: glycyrrhetinate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glycyrrhetinate." [GOC:TermGenie, pmid:22128119] +synonym: "glycyrrhetinate anabolism" EXACT [GOC:TermGenie] +synonym: "glycyrrhetinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "glycyrrhetinate formation" EXACT [GOC:TermGenie] +synonym: "glycyrrhetinate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019745 ! pentacyclic triterpenoid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1902384 ! glycyrrhetinate metabolic process + +[Term] +id: GO:1902387 +name: ceramide 1-phosphate binding +namespace: molecular_function +def: "Binding to ceramide 1-phosphate." [GOC:TermGenie, PMID:23863933] +is_a: GO:0005543 ! phospholipid binding +is_a: GO:0043168 ! anion binding +is_a: GO:0097001 ! ceramide binding + +[Term] +id: GO:1902388 +name: ceramide 1-phosphate transfer activity +namespace: molecular_function +def: "Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GOC:TermGenie, PMID:23863933] +synonym: "ceramide 1-phosphate carrier activity" EXACT [] +synonym: "ceramide 1-phosphate transporter activity" BROAD [] +synonym: "intermembrane ceramide 1-phosphate transfer activity" NARROW [] +xref: Reactome:R-HSA-5339535 "GLTPD1 transports C1P from plasma membrane to Golgi membrane" +is_a: GO:0120014 ! phospholipid transfer activity +is_a: GO:0120017 ! ceramide transfer activity + +[Term] +id: GO:1902389 +name: ceramide 1-phosphate transport +namespace: biological_process +def: "The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:23863933] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015914 ! phospholipid transport +is_a: GO:0035627 ! ceramide transport + +[Term] +id: GO:1902390 +name: regulation of N-terminal peptidyl-serine acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279] +is_a: GO:1901983 ! regulation of protein acetylation +is_a: GO:1903317 ! regulation of protein maturation +relationship: regulates GO:0017198 ! N-terminal peptidyl-serine acetylation + +[Term] +id: GO:1902391 +name: positive regulation of N-terminal peptidyl-serine acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-serine acetylation." [GOC:TermGenie, PMID:23912279] +synonym: "activation of N-terminal peptidyl-serine acetylation" NARROW [GOC:TermGenie] +synonym: "up regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] +synonym: "upregulation of N-terminal peptidyl-serine acetylation" EXACT [GOC:TermGenie] +is_a: GO:1901985 ! positive regulation of protein acetylation +is_a: GO:1902390 ! regulation of N-terminal peptidyl-serine acetylation +is_a: GO:1903319 ! positive regulation of protein maturation +relationship: positively_regulates GO:0017198 ! N-terminal peptidyl-serine acetylation + +[Term] +id: GO:1902392 +name: regulation of exodeoxyribonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie] +is_a: GO:0032070 ! regulation of deoxyribonuclease activity +is_a: GO:1905777 ! regulation of exonuclease activity + +[Term] +id: GO:1902393 +name: negative regulation of exodeoxyribonuclease activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie] +synonym: "down regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +synonym: "downregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +synonym: "inhibition of exodeoxyribonuclease activity" NARROW [GOC:TermGenie] +is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity +is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity +is_a: GO:1905778 ! negative regulation of exonuclease activity + +[Term] +id: GO:1902394 +name: positive regulation of exodeoxyribonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exodeoxyribonuclease activity." [GOC:jl, GOC:TermGenie, PMID:1234] +synonym: "activation of exodeoxyribonuclease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +synonym: "upregulation of exodeoxyribonuclease activity" EXACT [GOC:TermGenie] +is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity +is_a: GO:1902392 ! regulation of exodeoxyribonuclease activity +is_a: GO:1905779 ! positive regulation of exonuclease activity + +[Term] +id: GO:1902395 +name: regulation of 1-deoxy-D-xylulose-5-phosphate synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity." [GOC:TermGenie, PMID:23612965] +synonym: "regulation of 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [GOC:TermGenie] +synonym: "regulation of 1-deoxyxylulose-5-phosphate synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DOXP synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DXP-synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1902396 +name: protein localization to bicellular tight junction +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a bicellular tight junction." [GOC:TermGenie, PMID:18332111] +synonym: "protein localisation in tight junction" EXACT [GOC:TermGenie] +synonym: "protein localisation to tight junction" EXACT [GOC:TermGenie] +synonym: "protein localization in tight junction" EXACT [GOC:TermGenie] +is_a: GO:0150105 ! protein localization to cell-cell junction + +[Term] +id: GO:1902397 +name: obsolete detection of stimulus involved in meiotic spindle checkpoint +namespace: biological_process +def: "OBSOLETE. Any detection of stimulus that is involved in meiotic spindle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "perception of stimulus involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus detection involved in meiotic spindle checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in meiotic spindle checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902399 +name: obsolete detection of stimulus involved in G1 DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. Any detection of stimulus that is involved in G1 DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "perception of stimulus involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] +synonym: "perception of stimulus involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus detection involved in G1 DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus detection involved in G1/S DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in G1 DNA damage checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus sensing involved in G1/S DNA damage checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902401 +name: obsolete detection of stimulus involved in mitotic DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. Any detection of stimulus that is involved in mitotic DNA damage checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "perception of stimulus involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus detection involved in mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in mitotic DNA damage checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902404 +name: mitotic actomyosin contractile ring contraction +namespace: biological_process +def: "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "mitotic actomyosin contractile ring constriction" EXACT [GOC:vw] +is_a: GO:0000916 ! actomyosin contractile ring contraction +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1902405 +name: mitotic actomyosin contractile ring localization +namespace: biological_process +def: "Any actomyosin contractile ring localization that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0032187 ! actomyosin contractile ring localization +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1902406 +name: mitotic actomyosin contractile ring maintenance +namespace: biological_process +def: "Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0031566 ! actomyosin contractile ring maintenance +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1902407 +name: assembly of actomyosin apparatus involved in mitotic cytokinesis +namespace: biological_process +def: "Any assembly of mitotic cytokinetic actomyosin apparatus." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1902408 +name: mitotic cytokinesis, site selection +namespace: biological_process +def: "Any cytokinesis, site selection that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "site selection involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "site selection involved in cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0007105 ! cytokinesis, site selection +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1902410 +name: mitotic cytokinetic process +namespace: biological_process +def: "Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] +is_a: GO:0032506 ! cytokinetic process +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:1902412 +name: regulation of mitotic cytokinesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +is_a: GO:0032465 ! regulation of cytokinesis +relationship: regulates GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:1902413 +name: negative regulation of mitotic cytokinesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "down regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cytokinesis after mitosis" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +is_a: GO:0032466 ! negative regulation of cytokinesis +is_a: GO:1902412 ! regulation of mitotic cytokinesis +relationship: negatively_regulates GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:1902414 +name: protein localization to cell junction +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cell junction." [GOC:TermGenie, PMID:18332111] +synonym: "protein localisation in cell junction" EXACT [GOC:TermGenie] +synonym: "protein localisation to cell junction" EXACT [GOC:TermGenie] +synonym: "protein localization in cell junction" EXACT [GOC:TermGenie] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:1902415 +name: regulation of mRNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] +is_a: GO:1905214 ! regulation of RNA binding + +[Term] +id: GO:1902416 +name: positive regulation of mRNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA binding." [GOC:rb, GOC:TermGenie, PMID:22890846] +synonym: "activation of mRNA binding" NARROW [GOC:TermGenie] +synonym: "up regulation of mRNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA binding" EXACT [GOC:TermGenie] +is_a: GO:1902415 ! regulation of mRNA binding +is_a: GO:1905216 ! positive regulation of RNA binding + +[Term] +id: GO:1902417 +name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other." [GOC:TermGenie, PMID:24028845] +synonym: "ABA-GE transmembrane transporter activity" EXACT [] +synonym: "abscisic acid glucosyl ester transmembrane transporter activity" EXACT [] +is_a: GO:0042947 ! glucoside transmembrane transporter activity + +[Term] +id: GO:1902418 +name: (+)-abscisic acid D-glucopyranosyl ester transmembrane transport +namespace: biological_process +def: "The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane." [GOC:TermGenie, PMID:24028845] +synonym: "ABA-GE transmembrane transport" EXACT [] +synonym: "abscisic acid glucosyl ester transmembrane transport" EXACT [] +is_a: GO:0042946 ! glucoside transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1902421 +name: hydrogen metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761] +synonym: "dihydrogen metabolism" EXACT [GOC:TermGenie] +synonym: "H2 metabolism" EXACT [] +synonym: "molecular hydrogen metabolism" EXACT [] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1902422 +name: hydrogen biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen)." [GOC:mengo_curators, GOC:TermGenie, PMID:20395274, PMID:20692761] +synonym: "dihydrogen synthesis" EXACT [GOC:jl] +synonym: "H2 biosynthesis" EXACT [] +synonym: "hydrogen anabolism" EXACT [GOC:TermGenie] +synonym: "hydrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "hydrogen formation" EXACT [GOC:TermGenie] +synonym: "hydrogen generation" EXACT [GOC:jl] +synonym: "hydrogen production" EXACT [] +synonym: "hydrogen synthesis" EXACT [GOC:TermGenie] +synonym: "molecular hydrogen biosynthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:1902421 ! hydrogen metabolic process + +[Term] +id: GO:1902423 +name: regulation of attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639] +synonym: "regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] +synonym: "regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +is_a: GO:0090235 ! regulation of metaphase plate congression +relationship: regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1902424 +name: negative regulation of attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, GOC:vw, PMID:22065639] +synonym: "down regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "down regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "down regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "down-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "down-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "downregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "downregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "downregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "inhibition of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie] +synonym: "inhibition of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie] +synonym: "inhibition of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "negative regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] +synonym: "negative regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic attachment of spindle microtubules to kinetochore" EXACT [] +synonym: "negative regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +is_a: GO:0051986 ! negative regulation of attachment of spindle microtubules to kinetochore +is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore +relationship: negatively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1902425 +name: positive regulation of attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation." [GOC:TermGenie, PMID:22065639] +synonym: "activation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitosis" NARROW [GOC:TermGenie] +synonym: "activation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" NARROW [GOC:TermGenie] +synonym: "activation of attachment of spindle microtubules to mitotic chromosome" NARROW [GOC:TermGenie] +synonym: "activation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] +synonym: "positive regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to mitotic chromosome" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic bipolar attachment" RELATED [GOC:TermGenie] +is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore +is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore +relationship: positively_regulates GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1902426 +name: deactivation of mitotic spindle assembly checkpoint +namespace: biological_process +def: "A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:19075002, PMID:19592249] +comment: A mitotic spindle assembly checkpoint is either activated or switched off; no other means of reducing the frequency, rate or extent of this process are currently known. +synonym: "down regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "down regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "down regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "down-regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "down-regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "down-regulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "downregulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "downregulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "downregulation of mitotic spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "inhibition of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "inhibition of mitotic cell cycle spindle assembly checkpoint" RELATED [GOC:TermGenie] +synonym: "inhibition of mitotic spindle assembly checkpoint" RELATED [GOC:TermGenie] +synonym: "mitotic spindle assembly checkpoint silencing" EXACT [] +synonym: "mitotic spindle assembly deactivation" EXACT [] +synonym: "negative regulation of Mad2-dependent checkpoint" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitotic cell cycle spindle assembly checkpoint" BROAD [GOC:TermGenie] +synonym: "negative regulation of mitotic spindle assembly checkpoint" BROAD [] +is_a: GO:0140499 ! negative regulation of mitotic spindle assembly checkpoint signaling + +[Term] +id: GO:1902427 +name: regulation of water channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752] +synonym: "regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "regulation of aquaporin permeability" NARROW [PMID:22095752] +is_a: GO:0022898 ! regulation of transmembrane transporter activity + +[Term] +id: GO:1902428 +name: negative regulation of water channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity." [GOC:TermGenie] +synonym: "down regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "down regulation of water channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "down-regulation of water channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "downregulation of water channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of aquaporin" NARROW [GOC:TermGenie] +synonym: "inhibition of water channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of aquaporin" NARROW [GOC:TermGenie] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:1902427 ! regulation of water channel activity + +[Term] +id: GO:1902429 +name: positive regulation of water channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of water channel activity." [GOC:nhn, GOC:TermGenie, PMID:22095752] +synonym: "activation of aquaporin" NARROW [GOC:TermGenie] +synonym: "activation of water channel activity" NARROW [GOC:TermGenie] +synonym: "aquaporin activation" NARROW [PMID:22095752] +synonym: "positive regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "up regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "up regulation of water channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "up-regulation of water channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aquaporin" NARROW [GOC:TermGenie] +synonym: "upregulation of water channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:1902427 ! regulation of water channel activity + +[Term] +id: GO:1902430 +name: negative regulation of amyloid-beta formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation." [GOC:hjd, GOC:TermGenie, PMID:22992957] +synonym: "down regulation of beta-amyloid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-amyloid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-amyloid formation" EXACT [GOC:TermGenie] +synonym: "inhibition of beta-amyloid formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-amyloid formation" EXACT [] +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:1902003 ! regulation of amyloid-beta formation +is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process +relationship: negatively_regulates GO:0034205 ! amyloid-beta formation + +[Term] +id: GO:1902432 +name: protein localization to division septum +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a division septum." [GOC:TermGenie, PMID:9367977] +synonym: "protein localisation in division septum" EXACT [GOC:TermGenie] +synonym: "protein localisation to division septum" EXACT [GOC:TermGenie] +synonym: "protein localization in division septum" EXACT [GOC:TermGenie] +is_a: GO:0072741 ! protein localization to cell division site + +[Term] +id: GO:1902433 +name: positive regulation of water channel activity involved in maintenance of lens transparency +namespace: biological_process +def: "Any positive regulation of water channel activity that is involved in maintenance of lens transparency." [GOC:nhn, GOC:TermGenie, PMID:22095752] +synonym: "activation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "activation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "activation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "activation of water channel activity involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "activation of water channel activity involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "activation of water channel activity involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "aquaporin activation involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "aquaporin activation involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "aquaporin activation involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "positive regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "positive regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "positive regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "positive regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] +synonym: "positive regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] +synonym: "up regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "up regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "up regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "up regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] +synonym: "up regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] +synonym: "up regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] +synonym: "up-regulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "up-regulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "up-regulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "up-regulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] +synonym: "up-regulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] +synonym: "up-regulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] +synonym: "upregulation of aquaporin involved in maintenance of lens transparency" NARROW [GOC:TermGenie] +synonym: "upregulation of aquaporin involved in maintenance of ocular lens transparency" NARROW [GOC:TermGenie] +synonym: "upregulation of aquaporin involved in preservation of lens transparency" NARROW [GOC:TermGenie] +synonym: "upregulation of water channel activity involved in maintenance of lens transparency" EXACT [GOC:TermGenie] +synonym: "upregulation of water channel activity involved in maintenance of ocular lens transparency" EXACT [GOC:TermGenie] +synonym: "upregulation of water channel activity involved in preservation of lens transparency" EXACT [GOC:TermGenie] +is_a: GO:1902429 ! positive regulation of water channel activity +relationship: part_of GO:0036438 ! maintenance of lens transparency + +[Term] +id: GO:1902434 +name: sulfate import across plasma membrane +namespace: biological_process +def: "The directed movement of sulfate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:TermGenie, PMID:14723223] +synonym: "sulfate import into cell" EXACT [] +synonym: "sulphate import into cell" EXACT [] +is_a: GO:0098658 ! inorganic anion import across plasma membrane +is_a: GO:1902358 ! sulfate transmembrane transport + +[Term] +id: GO:1902435 +name: regulation of male mating behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] +is_a: GO:0050795 ! regulation of behavior +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060179 ! male mating behavior + +[Term] +id: GO:1902436 +name: negative regulation of male mating behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] +synonym: "down regulation of male mating behavior" EXACT [GOC:TermGenie] +synonym: "down-regulation of male mating behavior" EXACT [GOC:TermGenie] +synonym: "downregulation of male mating behavior" EXACT [GOC:TermGenie] +synonym: "inhibition of male mating behavior" NARROW [GOC:TermGenie] +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902435 ! regulation of male mating behavior +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060179 ! male mating behavior + +[Term] +id: GO:1902437 +name: positive regulation of male mating behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of male mating behavior." [GOC:TermGenie, PMID:24089208] +synonym: "activation of male mating behavior" NARROW [GOC:TermGenie] +synonym: "up regulation of male mating behavior" EXACT [GOC:TermGenie] +synonym: "up-regulation of male mating behavior" EXACT [GOC:TermGenie] +synonym: "upregulation of male mating behavior" EXACT [GOC:TermGenie] +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902435 ! regulation of male mating behavior +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060179 ! male mating behavior + +[Term] +id: GO:1902438 +name: response to vanadate(3-) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1902439 +name: cellular response to vanadate(3-) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vanadate(3-) stimulus." [GOC:di, GOC:TermGenie, PMID:7489911] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1902438 ! response to vanadate(3-) + +[Term] +id: GO:1902440 +name: protein localization to mitotic spindle pole body +namespace: biological_process +alt_id: GO:1990975 +def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body." [GOC:TermGenie, PMID:22438582] +synonym: "establishment of protein localization to mitotic spindle pole body" NARROW [] +synonym: "protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "protein localization in mitotic spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:0071988 ! protein localization to spindle pole body + +[Term] +id: GO:1902441 +name: protein localization to meiotic spindle pole body +namespace: biological_process +alt_id: GO:1990945 +alt_id: GO:1990954 +def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body." [PMID:20833892] +synonym: "establishment of protein localization to meiotic spindle pole body" NARROW [] +synonym: "protein localisation in meiotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "protein localisation to meiotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "protein localization in meiotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "protein location to meiotic spindle pole body" EXACT [] +is_a: GO:0071988 ! protein localization to spindle pole body +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:1990395 ! meiotic spindle pole body organization + +[Term] +id: GO:1902442 +name: regulation of ripoptosome assembly involved in necroptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097] +synonym: "regulation of ripoptosome assembly involved in necroptosis" NARROW [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process + +[Term] +id: GO:1902443 +name: negative regulation of ripoptosome assembly involved in necroptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:21052097] +synonym: "down regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of ripoptosome assembly involved in necroptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of ripoptosome assembly involved in necroptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of ripoptosome assembly involved in necroptosis" NARROW [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1902442 ! regulation of ripoptosome assembly involved in necroptotic process +relationship: negatively_regulates GO:1901026 ! ripoptosome assembly involved in necroptotic process + +[Term] +id: GO:1902444 +name: riboflavin binding +namespace: molecular_function +def: "Binding to riboflavin." [GOC:TermGenie, PMID:12083520] +is_a: GO:0043168 ! anion binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1902445 +name: regulation of mitochondrial membrane permeability involved in programmed necrotic cell death +namespace: biological_process +def: "Any regulation of mitochondrial membrane permeability that is involved in programmed necrotic cell death." [GOC:dph, GOC:mtg_apoptosis, GOC:TermGenie, PMID:22493254] +synonym: "regulation of transport across mitochondrial membrane involved in programmed necrotic cell death" EXACT [GOC:TermGenie] +is_a: GO:0046902 ! regulation of mitochondrial membrane permeability +relationship: part_of GO:0097300 ! programmed necrotic cell death + +[Term] +id: GO:1902446 +name: regulation of shade avoidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] +is_a: GO:2000030 ! regulation of response to red or far red light +relationship: regulates GO:0009641 ! shade avoidance + +[Term] +id: GO:1902447 +name: negative regulation of shade avoidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] +synonym: "down regulation of shade avoidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of shade avoidance" EXACT [GOC:TermGenie] +synonym: "downregulation of shade avoidance" EXACT [GOC:TermGenie] +synonym: "inhibition of shade avoidance" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1902446 ! regulation of shade avoidance +relationship: negatively_regulates GO:0009641 ! shade avoidance + +[Term] +id: GO:1902448 +name: positive regulation of shade avoidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of shade avoidance." [GOC:TermGenie, PMID:23763263] +synonym: "activation of shade avoidance" NARROW [GOC:TermGenie] +synonym: "up regulation of shade avoidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of shade avoidance" EXACT [GOC:TermGenie] +synonym: "upregulation of shade avoidance" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1902446 ! regulation of shade avoidance +relationship: positively_regulates GO:0009641 ! shade avoidance + +[Term] +id: GO:1902455 +name: negative regulation of stem cell population maintenance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] +synonym: "down regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "down regulation of stem cell maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "down-regulation of stem cell maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "downregulation of stem cell maintenance" EXACT [GOC:TermGenie] +synonym: "inhibition of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "inhibition of stem cell maintenance" NARROW [GOC:TermGenie] +synonym: "negative regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000036 ! regulation of stem cell population maintenance +relationship: negatively_regulates GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:1902456 +name: regulation of stomatal opening +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] +is_a: GO:0010119 ! regulation of stomatal movement +relationship: regulates GO:1990069 ! stomatal opening + +[Term] +id: GO:1902457 +name: negative regulation of stomatal opening +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] +synonym: "down regulation of stomatal opening" EXACT [GOC:TermGenie] +synonym: "down-regulation of stomatal opening" EXACT [GOC:TermGenie] +synonym: "downregulation of stomatal opening" EXACT [GOC:TermGenie] +synonym: "inhibition of stomatal opening" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1902456 ! regulation of stomatal opening +relationship: negatively_regulates GO:1990069 ! stomatal opening + +[Term] +id: GO:1902458 +name: positive regulation of stomatal opening +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stomatal opening." [GOC:TermGenie, PMID:23766366] +synonym: "activation of stomatal opening" NARROW [GOC:TermGenie] +synonym: "up regulation of stomatal opening" EXACT [GOC:TermGenie] +synonym: "up-regulation of stomatal opening" EXACT [GOC:TermGenie] +synonym: "upregulation of stomatal opening" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1902456 ! regulation of stomatal opening +relationship: positively_regulates GO:1990069 ! stomatal opening + +[Term] +id: GO:1902459 +name: positive regulation of stem cell population maintenance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stem cell population maintenance." [GOC:hjd, GOC:TermGenie, PMID:22969033] +synonym: "activation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "activation of stem cell maintenance" NARROW [GOC:TermGenie] +synonym: "positive regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "up regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "up regulation of stem cell maintenance" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "up-regulation of stem cell maintenance" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "upregulation of stem cell maintenance" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000036 ! regulation of stem cell population maintenance +relationship: positively_regulates GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:1902460 +name: regulation of mesenchymal stem cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] +synonym: "regulation of MSC proliferation" EXACT [GOC:TermGenie] +is_a: GO:0072091 ! regulation of stem cell proliferation +relationship: regulates GO:0097168 ! mesenchymal stem cell proliferation + +[Term] +id: GO:1902461 +name: negative regulation of mesenchymal stem cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] +synonym: "down regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of MSC proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of MSC proliferation" EXACT [GOC:TermGenie] +is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation +is_a: GO:2000647 ! negative regulation of stem cell proliferation +relationship: negatively_regulates GO:0097168 ! mesenchymal stem cell proliferation + +[Term] +id: GO:1902462 +name: positive regulation of mesenchymal stem cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell proliferation." [GOC:pm, GOC:TermGenie, PMID:18672106] +synonym: "activation of mesenchymal stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of MSC proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of MSC proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of mesenchymal stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of MSC proliferation" EXACT [GOC:TermGenie] +is_a: GO:1902460 ! regulation of mesenchymal stem cell proliferation +is_a: GO:2000648 ! positive regulation of stem cell proliferation +relationship: positively_regulates GO:0097168 ! mesenchymal stem cell proliferation + +[Term] +id: GO:1902463 +name: protein localization to cell leading edge +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cell leading edge." [GOC:lb, GOC:TermGenie, PMID:21543326] +synonym: "protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "protein localization in cell leading edge" EXACT [GOC:TermGenie] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:1902464 +name: regulation of histone H3-K27 trimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] +is_a: GO:0061085 ! regulation of histone H3-K27 methylation +relationship: regulates GO:0098532 ! histone H3-K27 trimethylation + +[Term] +id: GO:1902465 +name: negative regulation of histone H3-K27 trimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] +synonym: "down regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3-K27 trimethylation" NARROW [GOC:TermGenie] +is_a: GO:0061086 ! negative regulation of histone H3-K27 methylation +is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation +relationship: negatively_regulates GO:0098532 ! histone H3-K27 trimethylation + +[Term] +id: GO:1902466 +name: positive regulation of histone H3-K27 trimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation." [GOC:TermGenie, PMID:19270745] +synonym: "activation of histone H3-K27 trimethylation" NARROW [GOC:TermGenie] +synonym: "up regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K27 trimethylation" EXACT [GOC:TermGenie] +is_a: GO:0061087 ! positive regulation of histone H3-K27 methylation +is_a: GO:1902464 ! regulation of histone H3-K27 trimethylation +relationship: positively_regulates GO:0098532 ! histone H3-K27 trimethylation + +[Term] +id: GO:1902471 +name: regulation of mitotic actomyosin contractile ring localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring localization." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] +is_a: GO:1901648 ! regulation of actomyosin contractile ring localization +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:1902405 ! mitotic actomyosin contractile ring localization + +[Term] +id: GO:1902472 +name: regulation of mitotic cytokinesis, site selection +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cytokinesis, site selection." [GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +is_a: GO:2000073 ! regulation of cytokinesis, site selection +relationship: regulates GO:1902408 ! mitotic cytokinesis, site selection + +[Term] +id: GO:1902473 +name: regulation of protein localization to synapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] +synonym: "regulation of protein localisation to synapse" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +relationship: regulates GO:0035418 ! protein localization to synapse + +[Term] +id: GO:1902474 +name: positive regulation of protein localization to synapse +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to synapse." [GOC:kmv, GOC:TermGenie, PMID:22588719] +synonym: "activation of protein localisation to synapse" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to synapse" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to synapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to synapse" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to synapse" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to synapse" EXACT [GOC:TermGenie] +is_a: GO:1902473 ! regulation of protein localization to synapse +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0035418 ! protein localization to synapse + +[Term] +id: GO:1902475 +name: L-alpha-amino acid transmembrane transport +namespace: biological_process +def: "The directed movement of L-alpha-amino acid across a membrane." [GOC:kmv, GOC:TermGenie, PMID:14668347] +is_a: GO:0003333 ! amino acid transmembrane transport + +[Term] +id: GO:1902476 +name: chloride transmembrane transport +namespace: biological_process +def: "The process in which chloride is transported across a membrane." [GOC:TermGenie, GOC:vw] +is_a: GO:0006821 ! chloride transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1902480 +name: protein localization to mitotic spindle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle." [GOC:TermGenie, PMID:23885124] +synonym: "protein localisation in mitotic spindle" EXACT [GOC:TermGenie] +synonym: "protein localisation to mitotic spindle" EXACT [GOC:TermGenie] +synonym: "protein localization in mitotic spindle" EXACT [GOC:TermGenie] +is_a: GO:0072698 ! protein localization to microtubule cytoskeleton + +[Term] +id: GO:1902481 +name: gamma-tubulin complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex." [GOC:TermGenie, PMID:23885124] +synonym: "gamma-tubulin complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1902482 +name: regulatory T cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a regulatory T cell." [GOC:nhn, GOC:TermGenie, PMID:20471291] +synonym: "regulatory T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulatory T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulatory T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulatory T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulatory T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulatory T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulatory T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:1902483 +name: cytotoxic T cell pyroptotic process +namespace: biological_process +def: "Any pyroptotic process in a cytotoxic T cell." [GOC:nhn, GOC:TermGenie, PMID:32299851] +synonym: "cytotoxic T cell apoptosis" RELATED [GOC:TermGenie] +synonym: "cytotoxic T cell apoptotic process" RELATED [] +synonym: "cytotoxic T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "cytotoxic T lymphocyte apoptotic process" RELATED [GOC:TermGenie] +synonym: "cytotoxic T-cell apoptosis" RELATED [GOC:TermGenie] +synonym: "cytotoxic T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "cytotoxic T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "cytotoxic T-lymphocyte apoptotic process" RELATED [GOC:TermGenie] +is_a: GO:0070269 ! pyroptosis + +[Term] +id: GO:1902484 +name: Sertoli cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a Sertoli cell." [GOC:ic, GOC:TermGenie, PMID:17761895] +synonym: "Sertoli cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1902485 +name: L-cysteine binding +namespace: molecular_function +def: "Binding to L-cysteine." [GOC:bhm, GOC:TermGenie, PMID:12941942] +is_a: GO:0016597 ! amino acid binding +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0043169 ! cation binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:1902486 +name: protein localization to growing cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a growing cell tip." [GOC:TermGenie, PMID:23041194] +synonym: "protein localisation in growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization in growing cell tip" EXACT [GOC:TermGenie] +is_a: GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1902487 +name: protein localization to non-growing cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip." [GOC:TermGenie, PMID:21652630, PMID:23041194] +synonym: "protein localisation in non-growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to non-growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization in non-growing cell tip" EXACT [GOC:TermGenie] +is_a: GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1902488 +name: cholangiocyte apoptotic process +namespace: biological_process +def: "Any apoptotic process in a cholangiocyte." [GOC:TermGenie, PMID:22961800] +synonym: "cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1902489 +name: hepatoblast apoptotic process +namespace: biological_process +def: "Any apoptotic process in a hepatoblast." [GOC:TermGenie, PMID:22412967] +synonym: "hepatoblast apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1902490 +name: regulation of sperm capacitation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] +synonym: "regulation of sperm activation" RELATED [GOC:TermGenie] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:1903429 ! regulation of cell maturation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048240 ! sperm capacitation + +[Term] +id: GO:1902491 +name: negative regulation of sperm capacitation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] +synonym: "down regulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "down regulation of sperm capacitation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "down-regulation of sperm capacitation" EXACT [GOC:TermGenie] +synonym: "downregulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "downregulation of sperm capacitation" EXACT [GOC:TermGenie] +synonym: "inhibition of sperm activation" RELATED [GOC:TermGenie] +synonym: "inhibition of sperm capacitation" NARROW [GOC:TermGenie] +synonym: "negative regulation of sperm activation" RELATED [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902490 ! regulation of sperm capacitation +is_a: GO:1903430 ! negative regulation of cell maturation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048240 ! sperm capacitation + +[Term] +id: GO:1902492 +name: positive regulation of sperm capacitation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sperm capacitation." [GOC:hjd, GOC:TermGenie, PMID:22539676] +synonym: "activation of sperm activation" RELATED [GOC:TermGenie] +synonym: "activation of sperm capacitation" NARROW [GOC:TermGenie] +synonym: "positive regulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "up regulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "up regulation of sperm capacitation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "up-regulation of sperm capacitation" EXACT [GOC:TermGenie] +synonym: "upregulation of sperm activation" RELATED [GOC:TermGenie] +synonym: "upregulation of sperm capacitation" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902490 ! regulation of sperm capacitation +is_a: GO:1903431 ! positive regulation of cell maturation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048240 ! sperm capacitation + +[Term] +id: GO:1902493 +name: acetyltransferase complex +namespace: cellular_component +def: "A protein complex which is capable of acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1902494 +name: catalytic complex +namespace: cellular_component +def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] +subset: goslim_metagenomics +synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1902495 +name: transmembrane transporter complex +namespace: cellular_component +def: "A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other." [GOC:bhm, GOC:TermGenie, PMID:18024586] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1990351 ! transporter complex +relationship: part_of GO:0016021 ! integral component of membrane + +[Term] +id: GO:1902496 +name: obsolete protein binding involved in negative regulation of telomere maintenance via telomerase +namespace: molecular_function +def: "OBSOLETE. Any protein binding that is involved in negative regulation of telomere maintenance via telomerase." [GOC:dph, GOC:TermGenie, GOC:vw, PMID:24013504] +comment: The reason for obsoletion is that this should be captured as a GO-CAM model. +synonym: "protein binding involved in down regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] +synonym: "protein binding involved in down-regulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] +synonym: "protein binding involved in downregulation of telomere maintenance via telomerase activity" EXACT [GOC:TermGenie] +synonym: "protein binding involved in inhibition of telomere maintenance via telomerase" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902497 +name: iron-sulfur cluster transmembrane transport +namespace: biological_process +def: "A process in which an iron-sulfur cluster is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dph, GOC:TermGenie, PMID:19810706] +synonym: "iron-sulfur cluster transport" BROAD [] +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:1901678 ! iron coordination entity transport + +[Term] +id: GO:1902498 +name: regulation of protein autoubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405] +synonym: "regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +is_a: GO:0031396 ! regulation of protein ubiquitination +relationship: regulates GO:0051865 ! protein autoubiquitination + +[Term] +id: GO:1902499 +name: positive regulation of protein autoubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein autoubiquitination." [GOC:rb, GOC:TermGenie, PMID:24069405] +synonym: "activation of protein auto-ubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein auto-ubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of protein autoubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein autoubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of protein self-ubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein self-ubiquitinylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:1902498 ! regulation of protein autoubiquitination +relationship: positively_regulates GO:0051865 ! protein autoubiquitination + +[Term] +id: GO:1902500 +name: vacuolar HOPS complex +namespace: cellular_component +def: "Any HOPS complex that is part of a vacuolar membrane." [GOC:TermGenie, PMID:23645161] +synonym: "vacuolar membrane HOPS complex" EXACT [] +is_a: GO:0030897 ! HOPS complex +relationship: part_of GO:0005774 ! vacuolar membrane + +[Term] +id: GO:1902501 +name: lysosomal HOPS complex +namespace: cellular_component +def: "Any HOPS complex that is part of a lysosomal membrane." [GOC:TermGenie, PMID:23645161] +synonym: "lysosomal membrane HOPS complex" EXACT [] +is_a: GO:1902500 ! vacuolar HOPS complex +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:1902502 +name: multivesicular body HOPS complex +namespace: cellular_component +def: "Any HOPS complex that is part of a multivesicular body membrane." [GOC:TermGenie, PMID:23645161] +synonym: "multivesicular body membrane HOPS complex" EXACT [] +is_a: GO:0030897 ! HOPS complex +relationship: part_of GO:0032585 ! multivesicular body membrane + +[Term] +id: GO:1902503 +name: adenylyltransferase complex +namespace: cellular_component +def: "A protein complex which is capable of adenylyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:11713534] +synonym: "ThiF-ThiS complex" RELATED [GOC:dph] +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:1902507 +name: thiazole synthase complex +namespace: cellular_component +def: "A protein complex which is capable of thiazole synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933] +is_a: GO:1990228 ! sulfurtransferase complex + +[Term] +id: GO:1902508 +name: 2-iminoacetate synthase complex +namespace: cellular_component +def: "A protein complex which is capable of 2-iminoacetate synthase activity." [GOC:bhm, GOC:TermGenie, PMID:12650933] +synonym: "ThiH-ThiG complex" NARROW [GOC:bhm, GOC:dph] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1902509 +name: methionine-importing complex +namespace: cellular_component +def: "A protein complex which is capable of methionine-importing activity." [GOC:pr, GOC:TermGenie, PMID:23748165] +synonym: "methionine importer complex" EXACT [] +synonym: "methionine importing complex" EXACT [] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1902510 +name: regulation of apoptotic DNA fragmentation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351, PMID:15723341] +comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases (see GO:0006309 'apoptotic DNA fragmentation'). Gene products involved in compartmentalization of such nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). +synonym: "regulation of chromatinolysis" BROAD [GOC:TermGenie] +synonym: "regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "regulation of DNA fragmentation" BROAD [GOC:TermGenie] +synonym: "regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +is_a: GO:1903624 ! regulation of DNA catabolic process +relationship: regulates GO:0006309 ! apoptotic DNA fragmentation + +[Term] +id: GO:1902511 +name: negative regulation of apoptotic DNA fragmentation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] +synonym: "down regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "down regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "down-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "downregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] +synonym: "inhibition of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "negative regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation +is_a: GO:1903625 ! negative regulation of DNA catabolic process +relationship: negatively_regulates GO:0006309 ! apoptotic DNA fragmentation + +[Term] +id: GO:1902512 +name: positive regulation of apoptotic DNA fragmentation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic DNA fragmentation." [GOC:hjd, GOC:TermGenie, PMID:15572351] +synonym: "activation of apoptotic DNA fragmentation" NARROW [GOC:TermGenie] +synonym: "activation of DNA catabolic process during apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of DNA catabolism during apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of DNA fragmentation involved in apoptotic nuclear change" NARROW [GOC:TermGenie] +synonym: "activation of endonucleolytic DNA catabolic process involved in apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "positive regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "up regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "up-regulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic DNA fragmentation" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA catabolic process during apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA catabolism during apoptosis" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:TermGenie] +synonym: "upregulation of endonucleolytic DNA catabolic process involved in apoptosis" EXACT [GOC:TermGenie] +is_a: GO:1902510 ! regulation of apoptotic DNA fragmentation +is_a: GO:1903626 ! positive regulation of DNA catabolic process +relationship: positively_regulates GO:0006309 ! apoptotic DNA fragmentation + +[Term] +id: GO:1902513 +name: regulation of organelle transport along microtubule +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of organelle transport along microtubule." [GOC:dph, GOC:TermGenie, PMID:21147087] +synonym: "regulation of microtubule-based organelle localization" EXACT [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0072384 ! organelle transport along microtubule + +[Term] +id: GO:1902514 +name: regulation of calcium ion transmembrane transport via high voltage-gated calcium channel +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel." [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048] +synonym: "regulation of generation of L-type calcium current" RELATED [] +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +relationship: regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel + +[Term] +id: GO:1902515 +name: thioredoxin-disulfide reductase complex +namespace: cellular_component +def: "A protein complex which is capable of thioredoxin-disulfide reductase activity." [GOC:bhm, GOC:TermGenie, PMID:10947986] +comment: An example of this is thioredoxin reductase (TrxB) in E. coli [P0A9P4] in PMID:10947986. +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1902516 +name: sn-glycerol 3-phosphate binding +namespace: molecular_function +def: "Binding to sn-glycerol 3-phosphate." [GOC:bhm, GOC:TermGenie, PMID:23013274] +comment: An example of this is UgpB in E. coli [P0AG80] - see PMID:23013274. +is_a: GO:0043168 ! anion binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:1902517 +name: glycerol-3-phosphate-transporting ATPase complex +namespace: cellular_component +def: "A protein complex which is capable of glycerol-3-phosphate-transporting ATPase activity." [GOC:bhm, GOC:TermGenie, PMID:23013274] +comment: An example of this is UgpB in E. coli in PMID:23013274. +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:1902518 +name: response to cyclophosphamide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclophosphamide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1902519 +name: response to docetaxel trihydrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to docetaxel" RELATED [] +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1902520 +name: response to doxorubicin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1903416 ! response to glycoside + +[Term] +id: GO:1902521 +name: response to etoposide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an etoposide stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1904631 ! response to glucoside + +[Term] +id: GO:1902522 +name: response to 4'-epidoxorubicin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus." [GOC:dw, GOC:TermGenie, PMID:23648065] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +synonym: "response to epirubicin" RELATED [] +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1903416 ! response to glycoside + +[Term] +id: GO:1902523 +name: positive regulation of protein K63-linked ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination." [GOC:TermGenie, PMID:21931591] +comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. +synonym: "activation of protein K63-linked polyubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein K63-linked ubiquitination" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein K63-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein K63-linked ubiquitination" EXACT [GOC:TermGenie] +is_a: GO:1900044 ! regulation of protein K63-linked ubiquitination +is_a: GO:1902916 ! positive regulation of protein polyubiquitination +relationship: positively_regulates GO:0070534 ! protein K63-linked ubiquitination + +[Term] +id: GO:1902524 +name: positive regulation of protein K48-linked ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein K48-linked ubiquitination." [GOC:TermGenie, PMID:21931591] +comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. +synonym: "activation of protein K48-linked polyubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein K48-linked ubiquitination" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein K48-linked polyubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein K48-linked ubiquitination" EXACT [GOC:TermGenie] +is_a: GO:0061945 ! regulation of protein K48-linked ubiquitination +is_a: GO:1902916 ! positive regulation of protein polyubiquitination +relationship: positively_regulates GO:0070936 ! protein K48-linked ubiquitination + +[Term] +id: GO:1902525 +name: regulation of protein monoubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] +synonym: "regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031396 ! regulation of protein ubiquitination +relationship: regulates GO:0006513 ! protein monoubiquitination + +[Term] +id: GO:1902526 +name: negative regulation of protein monoubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] +synonym: "down regulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein monoubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of protein monoubiquitinylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein monoubiquitylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:1902525 ! regulation of protein monoubiquitination +relationship: negatively_regulates GO:0006513 ! protein monoubiquitination + +[Term] +id: GO:1902527 +name: positive regulation of protein monoubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein monoubiquitination." [GOC:TermGenie, PMID:21931591] +comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. +synonym: "activation of protein monoubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein monoubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of protein monoubiquitylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein monoubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein monoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein monoubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:1902525 ! regulation of protein monoubiquitination +relationship: positively_regulates GO:0006513 ! protein monoubiquitination + +[Term] +id: GO:1902528 +name: regulation of protein linear polyubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] +synonym: "regulation of M1 linkage" NARROW [GOC:TermGenie] +is_a: GO:1902914 ! regulation of protein polyubiquitination +relationship: regulates GO:0097039 ! protein linear polyubiquitination + +[Term] +id: GO:1902529 +name: negative regulation of protein linear polyubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] +synonym: "down regulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "down regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "down-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "downregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +synonym: "inhibition of M1 linkage" NARROW [GOC:TermGenie] +synonym: "inhibition of protein linear polyubiquitination" NARROW [GOC:TermGenie] +synonym: "negative regulation of M1 linkage" NARROW [GOC:TermGenie] +is_a: GO:1902528 ! regulation of protein linear polyubiquitination +is_a: GO:1902915 ! negative regulation of protein polyubiquitination +relationship: negatively_regulates GO:0097039 ! protein linear polyubiquitination + +[Term] +id: GO:1902530 +name: positive regulation of protein linear polyubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein linear polyubiquitination." [GOC:TermGenie, PMID:21931591] +comment: An example is BIRC2 (UniProt ID Q13490) in PMID:21931591. +synonym: "activation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "activation of protein linear polyubiquitination" NARROW [GOC:TermGenie] +synonym: "positive regulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "up regulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "up regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "up-regulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of M1 linkage" NARROW [GOC:TermGenie] +synonym: "upregulation of protein linear polyubiquitination" EXACT [GOC:TermGenie] +is_a: GO:1902528 ! regulation of protein linear polyubiquitination +is_a: GO:1902916 ! positive regulation of protein polyubiquitination +relationship: positively_regulates GO:0097039 ! protein linear polyubiquitination + +[Term] +id: GO:1902531 +name: regulation of intracellular signal transduction +namespace: biological_process +alt_id: GO:0010627 +def: "Any process that modulates the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] +synonym: "regulation of intracellular protein kinase cascade" NARROW [] +synonym: "regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] +synonym: "regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:1902532 +name: negative regulation of intracellular signal transduction +namespace: biological_process +alt_id: GO:0010741 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction." [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] +synonym: "down regulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of intracellular signaling cascade" NARROW [GOC:TermGenie] +synonym: "down regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "down regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "down regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "down-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of signal transmission via intracellular cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of intracellular signaling cascade" NARROW [GOC:TermGenie] +synonym: "downregulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular signaling cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular signaling chain" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "inhibition of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "negative regulation of intracellular protein kinase cascade" EXACT [] +synonym: "negative regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of intracellular signaling cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "negative regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "negative regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: negatively_regulates GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:1902533 +name: positive regulation of intracellular signal transduction +namespace: biological_process +alt_id: GO:0010740 +def: "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction." [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] +synonym: "activation of intracellular signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "activation of intracellular signaling cascade" NARROW [GOC:TermGenie] +synonym: "activation of intracellular signaling chain" NARROW [GOC:TermGenie] +synonym: "activation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "activation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "positive regulation of intracellular protein kinase cascade" NARROW [] +synonym: "positive regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "positive regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "up regulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "up regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "up-regulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +synonym: "upregulation of intracellular signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of intracellular signaling chain" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of signal transduction via intracellular signaling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of signal transmission via intracellular cascade" NARROW [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: positively_regulates GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:1902535 +name: obsolete multi-organism membrane invagination +namespace: biological_process +def: "OBSOLETE. A membrane invagination which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:1902537 +name: obsolete multi-organism pinocytosis +namespace: biological_process +def: "OBSOLETE. A pinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:1902539 +name: obsolete multi-organism macropinocytosis +namespace: biological_process +def: "OBSOLETE. A macropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:1902541 +name: obsolete multi-organism micropinocytosis +namespace: biological_process +def: "OBSOLETE. A micropinocytosis which involves another organism." [GOC:bf, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +is_obsolete: true + +[Term] +id: GO:1902542 +name: regulation of protein localization to mitotic spindle pole body +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626] +synonym: "regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:1902363 ! regulation of protein localization to spindle pole body +relationship: regulates GO:1902440 ! protein localization to mitotic spindle pole body + +[Term] +id: GO:1902543 +name: negative regulation of protein localization to mitotic spindle pole body +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body." [GOC:TermGenie, PMID:22809626] +synonym: "down regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to mitotic spindle pole body" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to mitotic spindle pole body" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to mitotic spindle pole body" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] +is_a: GO:1902364 ! negative regulation of protein localization to spindle pole body +is_a: GO:1902542 ! regulation of protein localization to mitotic spindle pole body +relationship: negatively_regulates GO:1902440 ! protein localization to mitotic spindle pole body + +[Term] +id: GO:1902544 +name: regulation of DNA N-glycosylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] +synonym: "regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1902545 +name: negative regulation of DNA N-glycosylase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] +synonym: "down regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "downregulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "inhibition of DNA glycosylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA N-glycosylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:1902544 ! regulation of DNA N-glycosylase activity + +[Term] +id: GO:1902546 +name: positive regulation of DNA N-glycosylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA N-glycosylase activity." [GOC:rph, GOC:TermGenie, PMID:15518571] +synonym: "activation of DNA glycosylase activity" NARROW [GOC:TermGenie] +synonym: "activation of DNA N-glycosylase activity" NARROW [GOC:TermGenie] +synonym: "activation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "up regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +synonym: "upregulation of DNA glycosylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA N-glycosylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of endonuclease VIII activity" RELATED [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1902544 ! regulation of DNA N-glycosylase activity + +[Term] +id: GO:1902547 +name: regulation of cellular response to vascular endothelial growth factor stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370] +synonym: "regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "regulation of cellular response to VEGF" EXACT [GOC:TermGenie] +synonym: "regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus + +[Term] +id: GO:1902548 +name: negative regulation of cellular response to vascular endothelial growth factor stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17895370] +comment: ADAMTS12 (UniProt ID P58397) in human in PMID:17895370 inhibits the formation of VEGF-induced tubular structures in BAE-1 cells (endothelial cell line). +synonym: "down regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to VEGF" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "down regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] +synonym: "down-regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to VEGF" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "down-regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] +synonym: "downregulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to vascular endothelial growth factor stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to VEGF" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "downregulation of cellular response to VEGFB" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to vascular endothelial growth factor" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to vascular endothelial growth factor stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to VEGF" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to VEGFB" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to VEGF" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to VEGFA" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to VEGFB" NARROW [GOC:TermGenie] +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus +relationship: negatively_regulates GO:0035924 ! cellular response to vascular endothelial growth factor stimulus + +[Term] +id: GO:1902549 +name: protein localization to Mei2 nuclear dot +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot." [GOC:TermGenie, PMID:23980030] +synonym: "protein localisation in Mei2 nuclear dot" EXACT [GOC:TermGenie] +synonym: "protein localisation to Mei2 nuclear dot" EXACT [GOC:TermGenie] +synonym: "protein localization in Mei2 nuclear dot" EXACT [GOC:TermGenie] +synonym: "protein localization to Mei2 dot" EXACT [] +is_a: GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1902550 +name: lymphoid lineage cell migration into thymus involved in thymus epithelium morphogenesis +namespace: biological_process +def: "Any lymphoid lineage cell migration into thymus that is involved in thymus epithelium morphogenesis." [GOC:cvs, GOC:TermGenie, PMID:22342843] +synonym: "lymphoid lineage cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "lymphoid lineage restricted progenitor cell migration into thymus involved in thymus epithelium morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0097535 ! lymphoid lineage cell migration into thymus +relationship: part_of GO:0097536 ! thymus epithelium morphogenesis + +[Term] +id: GO:1902551 +name: regulation of catalase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] +synonym: "regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CAT" RELATED [GOC:TermGenie] +synonym: "regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "regulation of optidase activity" EXACT [GOC:TermGenie] +is_a: GO:2000468 ! regulation of peroxidase activity + +[Term] +id: GO:1902552 +name: negative regulation of catalase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] +synonym: "down regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CAT" RELATED [GOC:TermGenie] +synonym: "down regulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "down regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CAT" RELATED [GOC:TermGenie] +synonym: "down-regulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "down-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CAT" RELATED [GOC:TermGenie] +synonym: "downregulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "downregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of caperase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CAT" RELATED [GOC:TermGenie] +synonym: "inhibition of catalase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of catalase reaction" NARROW [GOC:TermGenie] +synonym: "inhibition of catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of equilase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of optidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CAT" RELATED [GOC:TermGenie] +synonym: "negative regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "negative regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of optidase activity" EXACT [GOC:TermGenie] +is_a: GO:1902551 ! regulation of catalase activity +is_a: GO:2000469 ! negative regulation of peroxidase activity + +[Term] +id: GO:1902553 +name: positive regulation of catalase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of catalase activity." [GOC:TermGenie, PMID:24285797] +synonym: "activation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of caperase activity" NARROW [GOC:TermGenie] +synonym: "activation of CAT" RELATED [GOC:TermGenie] +synonym: "activation of catalase activity" NARROW [GOC:TermGenie] +synonym: "activation of catalase reaction" NARROW [GOC:TermGenie] +synonym: "activation of catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of equilase activity" NARROW [GOC:TermGenie] +synonym: "activation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "activation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "activation of optidase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CAT" RELATED [GOC:TermGenie] +synonym: "positive regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "positive regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CAT" RELATED [GOC:TermGenie] +synonym: "up regulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "up regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CAT" RELATED [GOC:TermGenie] +synonym: "up-regulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "up-regulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of optidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of bacterial catalase-peroxidase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of caperase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CAT" RELATED [GOC:TermGenie] +synonym: "upregulation of catalase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of catalase reaction" EXACT [GOC:TermGenie] +synonym: "upregulation of catalase-peroxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of equilase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of haem catalase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of heme catalase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of manganese catalase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of optidase activity" EXACT [GOC:TermGenie] +is_a: GO:1902551 ! regulation of catalase activity +is_a: GO:2000470 ! positive regulation of peroxidase activity + +[Term] +id: GO:1902554 +name: serine/threonine protein kinase complex +namespace: cellular_component +def: "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] +comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). +synonym: "PDR16 complex dimer" RELATED [] +synonym: "PDR16 complex homodimer" RELATED [] +is_a: GO:1902911 ! protein kinase complex + +[Term] +id: GO:1902555 +name: endoribonuclease complex +namespace: cellular_component +def: "A protein complex which is capable of endoribonuclease activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] +comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). +synonym: "Ire1 complex dimer" RELATED [] +synonym: "Ire1 complex homodimer" RELATED [] +synonym: "Ire1 complex homooligomer" RELATED [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1902556 +name: phosphatidylinositol transporter complex +namespace: cellular_component +def: "A protein complex which is capable of phosphatidylinositol transporter activity." [GOC:bhm, GOC:TermGenie, PMID:9890948] +comment: An example is PDR16 in S. cerevisiae (UniProt ID P53860) in PMID:9890948 (inferred from direct assay). +synonym: "Ire1 complex dimer" RELATED [] +synonym: "Ire1 complex homodimer" RELATED [] +synonym: "Ire1 complex homooligomer" RELATED [] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:1902557 +name: 5'-adenylyl sulfate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other." [GOC:TermGenie, PMID:24296033] +comment: An example of this is the YPR011C gene product in S. cerevisiae in PMID:24296033. +is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:1901682 ! sulfur compound transmembrane transporter activity + +[Term] +id: GO:1902558 +name: 5'-adenylyl sulfate transmembrane transport +namespace: biological_process +def: "The process in which 5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033] +synonym: "adenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0015868 ! purine ribonucleotide transport +is_a: GO:0051503 ! adenine nucleotide transport +is_a: GO:0072348 ! sulfur compound transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:1902559 +name: 3'-phospho-5'-adenylyl sulfate transmembrane transport +namespace: biological_process +def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane." [GOC:TermGenie, PMID:24296033] +synonym: "3'-phosphoadenosine 5'-phosphosulfate transmembrane transport" EXACT [PMID:24296033] +is_a: GO:0046963 ! 3'-phosphoadenosine 5'-phosphosulfate transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:1902560 +name: GMP reductase complex +namespace: cellular_component +def: "An oxidoreductase complex which is capable of GMP reductase activity. It catalyses the irreversible reaction: GMP + 2 H(+) + NADPH => IMP + NADP(+) + NH(4)(+)." [GOC:bhm, GOC:TermGenie, PMID:12009299] +comment: An example of this is GMPR2 in human (UniProt Symbol Q9P2T1) in PMID:12009299 (inferred from direct assay). +synonym: "GMP reductase" NARROW [] +synonym: "GMPR1 complex" NARROW [] +synonym: "GMPR2 complex" NARROW [] +synonym: "guanosine monophosphate reductase" NARROW [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1902561 +name: origin recognition complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex." [GOC:TermGenie, PMID:11717425] +synonym: "ORC assembly" EXACT [GOC:TermGenie] +synonym: "ORC formation" EXACT [GOC:TermGenie] +synonym: "origin of replication recognition complex assembly" EXACT [GOC:TermGenie] +synonym: "origin of replication recognition complex formation" EXACT [GOC:TermGenie] +synonym: "origin recognition complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1902562 +name: H4 histone acetyltransferase complex +namespace: cellular_component +def: "A protein complex which is capable of H4 histone acetyltransferase activity." [GOC:bhm, GOC:TermGenie, PMID:23775086] +comment: An example of this is Hpa2 in yeast [Q06592] in PMID:23775086 [IDA]. +synonym: "Hpa3 (homo-)dimer" NARROW [PMID:23775086] +synonym: "Hpa3 complex" NARROW [PMID:23775086] +is_a: GO:0000123 ! histone acetyltransferase complex + +[Term] +id: GO:1902563 +name: regulation of neutrophil activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0042119 ! neutrophil activation + +[Term] +id: GO:1902564 +name: negative regulation of neutrophil activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] +synonym: "down regulation of neutrophil activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of neutrophil activation" EXACT [GOC:TermGenie] +synonym: "downregulation of neutrophil activation" EXACT [GOC:TermGenie] +synonym: "inhibition of neutrophil activation" NARROW [GOC:TermGenie] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:1902563 ! regulation of neutrophil activation +relationship: negatively_regulates GO:0042119 ! neutrophil activation + +[Term] +id: GO:1902565 +name: positive regulation of neutrophil activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil activation." [GOC:TermGenie, PMID:17588661] +synonym: "activation of neutrophil activation" NARROW [GOC:TermGenie] +synonym: "up regulation of neutrophil activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of neutrophil activation" EXACT [GOC:TermGenie] +synonym: "upregulation of neutrophil activation" EXACT [GOC:TermGenie] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:1902563 ! regulation of neutrophil activation +relationship: positively_regulates GO:0042119 ! neutrophil activation + +[Term] +id: GO:1902566 +name: regulation of eosinophil activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] +is_a: GO:0002694 ! regulation of leukocyte activation +relationship: regulates GO:0043307 ! eosinophil activation + +[Term] +id: GO:1902567 +name: negative regulation of eosinophil activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] +synonym: "down regulation of eosinophil activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of eosinophil activation" EXACT [GOC:TermGenie] +synonym: "downregulation of eosinophil activation" EXACT [GOC:TermGenie] +synonym: "inhibition of eosinophil activation" NARROW [GOC:TermGenie] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:1902566 ! regulation of eosinophil activation +relationship: negatively_regulates GO:0043307 ! eosinophil activation + +[Term] +id: GO:1902568 +name: positive regulation of eosinophil activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil activation." [GOC:TermGenie, PMID:16254138] +synonym: "activation of eosinophil activation" NARROW [GOC:TermGenie] +synonym: "up regulation of eosinophil activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of eosinophil activation" EXACT [GOC:TermGenie] +synonym: "upregulation of eosinophil activation" EXACT [GOC:TermGenie] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:1902566 ! regulation of eosinophil activation +relationship: positively_regulates GO:0043307 ! eosinophil activation + +[Term] +id: GO:1902569 +name: negative regulation of activation of Janus kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK (Janus Activated Kinase) kinase activity." [GOC:TermGenie, PMID:16254138] +synonym: "down regulation of activation of JAK1 kinase activity" NARROW [] +synonym: "down regulation of activation of JAK1 protein" NARROW [] +synonym: "down regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] +synonym: "down regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] +synonym: "down regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] +synonym: "down-regulation of activation of JAK1 kinase activity" NARROW [] +synonym: "down-regulation of activation of JAK1 protein" NARROW [] +synonym: "down-regulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] +synonym: "down-regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] +synonym: "down-regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:TermGenie] +synonym: "downregulation of activation of JAK1 kinase activity" NARROW [] +synonym: "downregulation of activation of JAK1 protein" NARROW [] +synonym: "downregulation of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of tyrosine phosphorylation of JAK1 protein" NARROW [] +synonym: "downregulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] +synonym: "inhibition of activation of JAK1 kinase activity" NARROW [] +synonym: "inhibition of activation of JAK1 protein" NARROW [] +synonym: "inhibition of activation of JAK2 kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of activation of JAK2 protein" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine phosphorylation of JAK1 protein" NARROW [] +synonym: "inhibition of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] +synonym: "negative regulation of activation of JAK1 protein" NARROW [] +synonym: "negative regulation of activation of JAK2 kinase activity" NARROW [] +synonym: "negative regulation of activation of JAK2 protein" NARROW [GOC:TermGenie] +synonym: "negative regulation of tyrosine phosphorylation of JAK1 protein" NARROW [] +synonym: "negative regulation of tyrosine phosphorylation of JAK2 protein" RELATED [GOC:TermGenie] +is_a: GO:0010533 ! regulation of activation of Janus kinase activity +is_a: GO:0050732 ! negative regulation of peptidyl-tyrosine phosphorylation +relationship: negatively_regulates GO:0042976 ! activation of Janus kinase activity + +[Term] +id: GO:1902570 +name: protein localization to nucleolus +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] +synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] +is_a: GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1902571 +name: regulation of serine-type peptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] +synonym: "regulation of serine protease activity" NARROW [GOC:TermGenie] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:1902572 +name: negative regulation of serine-type peptidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] +synonym: "down regulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "down regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "downregulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of serine protease activity" NARROW [GOC:TermGenie] +synonym: "inhibition of serine-type peptidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of serine protease activity" NARROW [GOC:TermGenie] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:1902571 ! regulation of serine-type peptidase activity + +[Term] +id: GO:1902573 +name: positive regulation of serine-type peptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of serine-type peptidase activity." [GOC:krc, GOC:TermGenie, PMID:20179351] +synonym: "activation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "activation of serine-type peptidase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of serine protease activity" NARROW [GOC:TermGenie] +synonym: "upregulation of serine-type peptidase activity" EXACT [GOC:TermGenie] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:1902571 ! regulation of serine-type peptidase activity + +[Term] +id: GO:1902574 +name: obsolete negative regulation of leucine import by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in negative regulation of leucine import." [GOC:TermGenie, PMID:22992726] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1902575 +name: protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +namespace: biological_process +def: "Any protein localization to cell division site that is involved in cytokinesis, actomyosin contractile ring assembly." [GOC:al, GOC:TermGenie, PMID:24127216] +synonym: "protein localisation to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] +synonym: "protein localisation to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] +synonym: "protein localization to cell division site involved in constriction ring assembly" NARROW [GOC:TermGenie] +synonym: "protein localization to cell division site involved in contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "protein localization to cell division site involved in cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] +synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] +synonym: "protein localization to cell division site involved in cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] +synonym: "protein localization to cell division site involved in cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0072741 ! protein localization to cell division site +relationship: part_of GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:1902576 +name: negative regulation of nuclear cell cycle DNA replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication." [GOC:TermGenie, PMID:19033384] +synonym: "down regulation of DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "down regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "down-regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "downregulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "inhibition of DNA replication involved in S phase" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replication involved in S-phase" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA replication during S phase" RELATED [GOC:TermGenie] +synonym: "negative regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication +is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0033260 ! nuclear DNA replication + +[Term] +id: GO:1902577 +name: protein localization to medial cortical node +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a medial cortical node." [GOC:TermGenie, PMID:24127216] +synonym: "protein localisation in medial cortical node" EXACT [GOC:TermGenie] +synonym: "protein localisation to medial cortical node" EXACT [GOC:TermGenie] +synonym: "protein localization in medial cortical node" EXACT [GOC:TermGenie] +is_a: GO:0071574 ! protein localization to medial cortex + +[Term] +id: GO:1902579 +name: obsolete multi-organism localization +namespace: biological_process +def: "OBSOLETE. A localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism localization" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902581 +name: obsolete multi-organism cellular localization +namespace: biological_process +def: "OBSOLETE. A cellular localization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism cellular localization" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902583 +name: obsolete multi-organism intracellular transport +namespace: biological_process +def: "OBSOLETE. An intracellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism intracellular transport" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902584 +name: positive regulation of response to water deprivation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to water deprivation." [GO_REF:0000058, GOC:TermGenie, PMID:24198318] +synonym: "activation of drought tolerance" RELATED [GOC:TermGenie] +synonym: "activation of response to dehydration" NARROW [GOC:TermGenie] +synonym: "activation of response to drought" NARROW [GOC:TermGenie] +synonym: "activation of response to thirst" NARROW [GOC:TermGenie] +synonym: "activation of response to water deprivation" NARROW [GOC:TermGenie] +synonym: "positive regulation of drought tolerance" RELATED [GOC:TermGenie] +synonym: "positive regulation of response to dehydration" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to drought" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to thirst" EXACT [GOC:TermGenie] +synonym: "up regulation of drought tolerance" RELATED [GOC:TermGenie] +synonym: "up regulation of response to dehydration" EXACT [GOC:TermGenie] +synonym: "up regulation of response to drought" EXACT [GOC:TermGenie] +synonym: "up regulation of response to thirst" EXACT [GOC:TermGenie] +synonym: "up regulation of response to water deprivation" EXACT [GOC:TermGenie] +synonym: "up-regulation of drought tolerance" RELATED [GOC:TermGenie] +synonym: "up-regulation of response to dehydration" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to drought" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to thirst" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to water deprivation" EXACT [GOC:TermGenie] +synonym: "upregulation of drought tolerance" RELATED [GOC:TermGenie] +synonym: "upregulation of response to dehydration" EXACT [GOC:TermGenie] +synonym: "upregulation of response to drought" EXACT [GOC:TermGenie] +synonym: "upregulation of response to thirst" EXACT [GOC:TermGenie] +synonym: "upregulation of response to water deprivation" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2000070 ! regulation of response to water deprivation +relationship: positively_regulates GO:0009414 ! response to water deprivation + +[Term] +id: GO:1902586 +name: obsolete multi-organism intercellular transport +namespace: biological_process +def: "OBSOLETE. An intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism intercellular transport" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902588 +name: obsolete multi-organism plasmodesmata-mediated intercellular transport +namespace: biological_process +def: "OBSOLETE. A plasmodesmata-mediated intercellular transport which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism plasmodesmata-mediated intercellular transport" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902590 +name: obsolete multi-organism organelle organization +namespace: biological_process +def: "OBSOLETE. An organelle organization which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism organelle organization" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902592 +name: obsolete multi-organism membrane budding +namespace: biological_process +def: "OBSOLETE. A membrane budding which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: Obsoleted because it was a grouping term for a viral process that was incorrectly under 'multi-organism cellular process'. The children terms have been moved under 'viral process', so that this grouping term is not necessary anymore. +synonym: "multi organism membrane budding" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902594 +name: obsolete multi-organism nuclear import +namespace: biological_process +def: "OBSOLETE. A nuclear import which involves another organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "multi organism nuclear import" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902595 +name: regulation of DNA replication origin binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] +synonym: "regulation of ARS binding" NARROW [GOC:TermGenie] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:1902596 +name: negative regulation of DNA replication origin binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] +synonym: "down regulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "down regulation of DNA replication origin binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "down-regulation of DNA replication origin binding" EXACT [GOC:TermGenie] +synonym: "downregulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "downregulation of DNA replication origin binding" EXACT [GOC:TermGenie] +synonym: "inhibition of ARS binding" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replication origin binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of ARS binding" NARROW [GOC:TermGenie] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:1902595 ! regulation of DNA replication origin binding + +[Term] +id: GO:1902597 +name: positive regulation of DNA replication origin binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA replication origin binding." [GO_REF:0000059, GOC:TermGenie, PMID:11850415] +synonym: "activation of ARS binding" NARROW [GOC:TermGenie] +synonym: "activation of DNA replication origin binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "up regulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA replication origin binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "up-regulation of DNA replication origin binding" EXACT [GOC:TermGenie] +synonym: "upregulation of ARS binding" NARROW [GOC:TermGenie] +synonym: "upregulation of DNA replication origin binding" EXACT [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:1902595 ! regulation of DNA replication origin binding + +[Term] +id: GO:1902599 +name: sulfathiazole transmembrane transport +namespace: biological_process +alt_id: GO:0015906 +def: "The directed movement of sulfathiazole across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "sulfathiazole transport" BROAD [] +synonym: "sulphathiazole transport" BROAD [] +is_a: GO:0042886 ! amide transport +is_a: GO:0045117 ! azole transmembrane transport +is_a: GO:0072348 ! sulfur compound transport + +[Term] +id: GO:1902600 +name: proton transmembrane transport +namespace: biological_process +alt_id: GO:0006818 +alt_id: GO:0015991 +alt_id: GO:0015992 +def: "The directed movement of a proton across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +subset: goslim_pir +synonym: "ATP hydrolysis coupled proton transport" NARROW [] +synonym: "hydrogen ion transmembrane transport" EXACT [] +synonym: "hydrogen ion transport" RELATED [] +synonym: "hydrogen transmembrane transport" EXACT [] +synonym: "hydrogen transport" BROAD [] +synonym: "passive proton transport, down the electrochemical gradient" NARROW [] +synonym: "proton transport" BROAD [] +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:1902601 +name: silver ion transmembrane transport +namespace: biological_process +def: "The directed movement of silver ion across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "silver transmembrane transport" BROAD [] +is_a: GO:0098660 ! inorganic ion transmembrane transport + +[Term] +id: GO:1902602 +name: aluminum ion transmembrane transport +namespace: biological_process +def: "The process in which an aluminium ion is transported across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "aluminium ion transmembrane transport" EXACT [] +synonym: "aluminium transmembrane transport" BROAD [] +synonym: "aluminum transmembrane transport" BROAD [] +is_a: GO:0098660 ! inorganic ion transmembrane transport + +[Term] +id: GO:1902603 +name: carnitine transmembrane transport +namespace: biological_process +def: "The directed movement of carnitine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +is_a: GO:0015879 ! carnitine transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1902604 +name: p-aminobenzoyl-glutamate transmembrane transport +namespace: biological_process +def: "The directed movement of N-(4-aminobenzoyl)-L-glutamate across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "N-(4-aminobenzoyl)-L-glutamate transmembrane transport" EXACT [] +is_a: GO:0015814 ! p-aminobenzoyl-glutamate transport +is_a: GO:0035442 ! dipeptide transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1902605 +name: heterotrimeric G-protein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a heterotrimeric G-protein complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:23637185] +synonym: "heterotrimeric G-protein complex formation" EXACT [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase activity assembly" RELATED [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase activity formation" RELATED [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit assembly" NARROW [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, alpha-subunit formation" NARROW [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, beta-subunit assembly" NARROW [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, beta-subunit formation" NARROW [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit assembly" NARROW [GOC:TermGenie] +synonym: "heterotrimeric G-protein GTPase, gamma-subunit formation" NARROW [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1902606 +name: regulation of large conductance calcium-activated potassium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] +synonym: "regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1902607 +name: negative regulation of large conductance calcium-activated potassium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] +synonym: "down regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "down regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "down regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "down-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "down-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "downregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "downregulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "downregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "inhibition of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of BK channel activity" RELATED [GOC:TermGenie] +synonym: "inhibition of BK KCa channels" NARROW [GOC:TermGenie] +synonym: "inhibition of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of large conductance KCa channels" NARROW [GOC:TermGenie] +synonym: "negative regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "negative regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity +is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1902608 +name: positive regulation of large conductance calcium-activated potassium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of large conductance calcium-activated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:23407708] +synonym: "activation of BK calcium-activated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "activation of BK KCa channels" NARROW [GOC:TermGenie] +synonym: "activation of large conductance calcium-activated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of large conductance KCa channels" NARROW [GOC:TermGenie] +synonym: "positive regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "positive regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "up regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "up regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "up regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "up-regulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "up-regulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of large conductance KCa channels" EXACT [GOC:TermGenie] +synonym: "upregulation of BK calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of BK channel activity" RELATED [GOC:TermGenie] +synonym: "upregulation of BK KCa channels" EXACT [GOC:TermGenie] +synonym: "upregulation of large conductance calcium-activated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of large conductance KCa channels" EXACT [GOC:TermGenie] +is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity +is_a: GO:1902606 ! regulation of large conductance calcium-activated potassium channel activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1902609 +name: (R)-2-hydroxy-alpha-linolenic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of (R)-2-hydroxy-alpha-linolenic acid." [GO_REF:0000068, GOC:TermGenie, PMID:24214535] +synonym: "(R)-2-hydroxy-alpha-linolenic acid anabolism" EXACT [GOC:TermGenie] +synonym: "(R)-2-hydroxy-alpha-linolenic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "(R)-2-hydroxy-alpha-linolenic acid formation" EXACT [GOC:TermGenie] +synonym: "(R)-2-hydroxy-alpha-linolenic acid synthesis" EXACT [GOC:TermGenie] +synonym: "2-hydroxy-octadecatrienoic acid biosynthesis" BROAD [] +is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process +is_a: GO:0042759 ! long-chain fatty acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process + +[Term] +id: GO:1902610 +name: response to N-phenylthiourea +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1902611 +name: cellular response to N-phenylthiourea +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a N-phenylthiourea stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:24006265] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1902610 ! response to N-phenylthiourea + +[Term] +id: GO:1902612 +name: regulation of anti-Mullerian hormone signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:1990262 ! anti-Mullerian hormone signaling pathway + +[Term] +id: GO:1902613 +name: negative regulation of anti-Mullerian hormone signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] +synonym: "down regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway +relationship: negatively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway + +[Term] +id: GO:1902614 +name: positive regulation of anti-Mullerian hormone signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anti-Mullerian hormone signaling pathway." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23624077] +synonym: "activation of anti-Mullerian hormone signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of anti-Mullerian hormone signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902612 ! regulation of anti-Mullerian hormone signaling pathway +relationship: positively_regulates GO:1990262 ! anti-Mullerian hormone signaling pathway + +[Term] +id: GO:1902615 +name: immune response involved in response to exogenous dsRNA +namespace: biological_process +def: "Any immune response that is involved in response to exogenous dsRNA." [GO_REF:0000060, GOC:pg, GOC:TermGenie, PMID:21266579] +synonym: "immune response involved in response to exogenous double-stranded RNA" EXACT [GOC:TermGenie] +synonym: "immune response involved in response to viral dsRNA" NARROW [GOC:TermGenie] +is_a: GO:0006955 ! immune response +relationship: part_of GO:0043330 ! response to exogenous dsRNA + +[Term] +id: GO:1902616 +name: acyl carnitine transmembrane transport +namespace: biological_process +def: "The process in which acyl carnitine is transported across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] +synonym: "O-acylcarnitine transmembrane transport" EXACT [] +is_a: GO:0006844 ! acyl carnitine transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1902617 +name: response to fluoride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:1902618 +name: cellular response to fluoride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus." [GO_REF:0000071, GOC:kmv, GOC:TermGenie, PMID:8138152] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1902617 ! response to fluoride + +[Term] +id: GO:1902619 +name: regulation of microtubule minus-end binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623] +is_a: GO:1904526 ! regulation of microtubule binding + +[Term] +id: GO:1902620 +name: positive regulation of microtubule minus-end binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule minus-end binding." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:22939623] +synonym: "activation of microtubule minus-end binding" NARROW [GOC:TermGenie] +synonym: "up regulation of microtubule minus-end binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule minus-end binding" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule minus-end binding" EXACT [GOC:TermGenie] +is_a: GO:1902619 ! regulation of microtubule minus-end binding +is_a: GO:1904528 ! positive regulation of microtubule binding + +[Term] +id: GO:1902621 +name: actomyosin contractile ring disassembly +namespace: biological_process +def: "The disaggregation of an actomyosin contractile ring into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:14602073, PMID:22891673] +synonym: "actomyosin ring disassembly" RELATED [GOC:TermGenie] +synonym: "CAR disassembly" EXACT [GOC:TermGenie] +synonym: "constriction ring disassembly" RELATED [GOC:TermGenie] +synonym: "contractile actomyosin ring disassembly" EXACT [GOC:TermGenie] +synonym: "cytokinetic ring disassembly" RELATED [GOC:TermGenie] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0032506 ! cytokinetic process +is_a: GO:0044837 ! actomyosin contractile ring organization + +[Term] +id: GO:1902622 +name: regulation of neutrophil migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:1990266 ! neutrophil migration + +[Term] +id: GO:1902623 +name: negative regulation of neutrophil migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] +synonym: "down regulation of neutrophil migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of neutrophil migration" EXACT [GOC:TermGenie] +synonym: "downregulation of neutrophil migration" EXACT [GOC:TermGenie] +synonym: "inhibition of neutrophil migration" NARROW [GOC:TermGenie] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:1902622 ! regulation of neutrophil migration +relationship: negatively_regulates GO:1990266 ! neutrophil migration + +[Term] +id: GO:1902624 +name: positive regulation of neutrophil migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil migration." [GO_REF:0000058, GOC:TermGenie, PMID:1826836] +synonym: "activation of neutrophil migration" NARROW [GOC:TermGenie] +synonym: "up regulation of neutrophil migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of neutrophil migration" EXACT [GOC:TermGenie] +synonym: "upregulation of neutrophil migration" EXACT [GOC:TermGenie] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:1902622 ! regulation of neutrophil migration +relationship: positively_regulates GO:1990266 ! neutrophil migration + +[Term] +id: GO:1902625 +name: obsolete negative regulation of induction of conjugation with cellular fusion by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:9671458] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1902626 +name: assembly of large subunit precursor of preribosome +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the large subunit precursor of the preribosome." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:22735702] +synonym: "66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:1902627 +name: regulation of assembly of large subunit precursor of preribosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702] +synonym: "regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "regulation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1902626 ! assembly of large subunit precursor of preribosome + +[Term] +id: GO:1902628 +name: positive regulation of assembly of large subunit precursor of preribosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of assembly of a large subunit precursor of preribosome." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22735702] +synonym: "activation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "activation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "activation of assembly of large subunit precursor of preribosome" NARROW [GOC:TermGenie] +synonym: "activation of preribosome, large subunit precursor formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +synonym: "up regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "up regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] +synonym: "up regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +synonym: "upregulation of 66S preribosome assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of 66S preribosome formation" NARROW [GOC:TermGenie] +synonym: "upregulation of assembly of large subunit precursor of preribosome" EXACT [GOC:TermGenie] +synonym: "upregulation of preribosome, large subunit precursor formation" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1902627 ! regulation of assembly of large subunit precursor of preribosome +relationship: positively_regulates GO:1902626 ! assembly of large subunit precursor of preribosome + +[Term] +id: GO:1902629 +name: regulation of mRNA stability involved in cellular response to UV +namespace: biological_process +def: "Any regulation of mRNA stability that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:10954610] +synonym: "regulation of mRNA stability involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA stability involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA stability involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA stability involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie] +is_a: GO:0043488 ! regulation of mRNA stability +relationship: part_of GO:0034644 ! cellular response to UV + +[Term] +id: GO:1902630 +name: regulation of membrane hyperpolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] +is_a: GO:0042391 ! regulation of membrane potential +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0060081 ! membrane hyperpolarization + +[Term] +id: GO:1902631 +name: negative regulation of membrane hyperpolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] +synonym: "down regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane hyperpolarization" NARROW [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1902630 ! regulation of membrane hyperpolarization +relationship: negatively_regulates GO:0060081 ! membrane hyperpolarization + +[Term] +id: GO:1902632 +name: positive regulation of membrane hyperpolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane hyperpolarization." [GO_REF:0000058, GOC:TermGenie, PMID:23223304] +synonym: "activation of membrane hyperpolarization" NARROW [GOC:TermGenie] +synonym: "up regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane hyperpolarization" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1902630 ! regulation of membrane hyperpolarization +relationship: positively_regulates GO:0060081 ! membrane hyperpolarization + +[Term] +id: GO:1902633 +name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] +comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:1902634 +name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] +comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0031161 ! phosphatidylinositol catabolic process +is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process + +[Term] +id: GO:1902635 +name: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:22562153] +comment: Phosphatidylinositol-4,5-bisphosphate, PtdIns(4,5)P(2) common name. +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process +is_a: GO:1902633 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process + +[Term] +id: GO:1902636 +name: kinociliary basal body +namespace: cellular_component +def: "A ciliary basal body that is part of a kinocilium." [GO_REF:0000064, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:15855039, PMID:15882574] +synonym: "cilial basal body of kinocilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of kinocilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of kinocilium" EXACT [GOC:TermGenie] +synonym: "kinocilial basal body" EXACT [] +synonym: "kinocilium basal body" EXACT [] +synonym: "kinocilium ciliary basal body" EXACT [] +synonym: "microtubule basal body of kinocilium" EXACT [GOC:TermGenie] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0060091 ! kinocilium + +[Term] +id: GO:1902637 +name: neural crest cell differentiation involved in thymus development +namespace: biological_process +def: "Any neural crest cell differentiation that is involved in thymus development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317, PMID:18292542] +is_a: GO:0014033 ! neural crest cell differentiation +relationship: part_of GO:0048538 ! thymus development + +[Term] +id: GO:1902638 +name: neural crest cell differentiation involved in parathyroid gland development +namespace: biological_process +def: "Any neural crest cell differentiation that is involved in parathyroid gland development." [GO_REF:0000060, GOC:nhn, GOC:TermGenie, PMID:15741317] +is_a: GO:0014033 ! neural crest cell differentiation +relationship: part_of GO:0060017 ! parathyroid gland development + +[Term] +id: GO:1902639 +name: propan-2-ol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237] +synonym: "Isopropanol metabolic process" EXACT [] +synonym: "Isopropyl alcohol metabolic process" EXACT [] +synonym: "propan-2-ol metabolism" EXACT [GOC:TermGenie] +is_a: GO:1902652 ! secondary alcohol metabolic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:1902640 +name: propan-2-ol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of propan-2-ol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16346237] +synonym: "Isopropanol biosynthetic process" EXACT [] +synonym: "Isopropyl alcohol biosynthetic process" EXACT [] +synonym: "propan-2-ol anabolism" EXACT [GOC:TermGenie] +synonym: "propan-2-ol biosynthesis" EXACT [GOC:TermGenie] +synonym: "propan-2-ol formation" EXACT [GOC:TermGenie] +synonym: "propan-2-ol synthesis" EXACT [GOC:TermGenie] +is_a: GO:1902639 ! propan-2-ol metabolic process +is_a: GO:1902653 ! secondary alcohol biosynthetic process +is_a: GO:1903175 ! fatty alcohol biosynthetic process + +[Term] +id: GO:1902641 +name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0060696 ! regulation of phospholipid catabolic process +relationship: regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process + +[Term] +id: GO:1902642 +name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0050995 ! negative regulation of lipid catabolic process +is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +is_a: GO:1903726 ! negative regulation of phospholipid metabolic process +relationship: negatively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process + +[Term] +id: GO:1902643 +name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0060697 ! positive regulation of phospholipid catabolic process +is_a: GO:1902641 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process +relationship: positively_regulates GO:1902634 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process + +[Term] +id: GO:1902644 +name: tertiary alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] +synonym: "tertiary alcohol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006066 ! alcohol metabolic process + +[Term] +id: GO:1902645 +name: tertiary alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of tertiary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] +synonym: "tertiary alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "tertiary alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "tertiary alcohol formation" EXACT [GOC:TermGenie] +synonym: "tertiary alcohol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:1902644 ! tertiary alcohol metabolic process + +[Term] +id: GO:1902646 +name: regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process +relationship: regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process + +[Term] +id: GO:1902647 +name: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "down regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010512 ! negative regulation of phosphatidylinositol biosynthetic process +is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +relationship: negatively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process + +[Term] +id: GO:1902648 +name: positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22562153] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" NARROW [GOC:TermGenie] +synonym: "activation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010513 ! positive regulation of phosphatidylinositol biosynthetic process +is_a: GO:1902646 ! regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process +relationship: positively_regulates GO:1902635 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process + +[Term] +id: GO:1902649 +name: obsolete regulation of histone H2A-H2B dimer displacement +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0140713 + +[Term] +id: GO:1902650 +name: obsolete negative regulation of histone H2A-H2B dimer displacement +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:0140713 + +[Term] +id: GO:1902651 +name: obsolete positive regulation of histone H2A-H2B dimer displacement +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of histone H2A-H2B dimer displacement." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:22199252] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of histone H2A-H2B dimer displacement" NARROW [GOC:TermGenie] +synonym: "up regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H2A-H2B dimer displacement" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0140713 + +[Term] +id: GO:1902652 +name: secondary alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] +synonym: "secondary alcohol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006066 ! alcohol metabolic process + +[Term] +id: GO:1902653 +name: secondary alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of secondary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200] +synonym: "secondary alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "secondary alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "secondary alcohol formation" EXACT [GOC:TermGenie] +synonym: "secondary alcohol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:1902652 ! secondary alcohol metabolic process + +[Term] +id: GO:1902654 +name: aromatic primary alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878] +synonym: "aromatic primary alcohol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:1902655 +name: aromatic primary alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of aromatic primary alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:19219878] +synonym: "aromatic primary alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "aromatic primary alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "aromatic primary alcohol formation" EXACT [GOC:TermGenie] +synonym: "aromatic primary alcohol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1902654 ! aromatic primary alcohol metabolic process + +[Term] +id: GO:1902656 +name: calcium ion import into cytosol +namespace: biological_process +def: "The directed movement of calcium ion into a cytosol." [GO_REF:0000075, GOC:TermGenie, GOC:vw] +synonym: "calcium import into cytosol" BROAD [] +is_a: GO:0060402 ! calcium ion transport into cytosol +is_a: GO:0070509 ! calcium ion import + +[Term] +id: GO:1902657 +name: protein localization to prospore membrane +namespace: biological_process +alt_id: GO:0072693 +alt_id: GO:1902658 +def: "A process in which a protein is transported to, or maintained in, a location within a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347] +synonym: "establishment of protein localisation in prospore membrane" RELATED [GOC:TermGenie] +synonym: "establishment of protein localisation to prospore membrane" RELATED [GOC:TermGenie] +synonym: "establishment of protein localization in prospore membrane" RELATED [GOC:TermGenie] +synonym: "establishment of protein localization to prospore membrane" RELATED [] +synonym: "protein localisation in prospore membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to prospore membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in prospore membrane" EXACT [GOC:TermGenie] +synonym: "protein targeting to ascospore-type prospore membrane" RELATED [GOC:mah] +synonym: "protein targeting to forespore membrane" RELATED [GOC:mah] +synonym: "protein targeting to FSM" RELATED [GOC:mah] +synonym: "protein targeting to prospore membrane" RELATED [] +synonym: "protein-prospore membrane targeting" RELATED [GOC:mah] +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1902659 +name: regulation of glucose mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] +synonym: "regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0010255 ! glucose mediated signaling pathway + +[Term] +id: GO:1902660 +name: negative regulation of glucose mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] +synonym: "down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902659 ! regulation of glucose mediated signaling pathway +relationship: negatively_regulates GO:0010255 ! glucose mediated signaling pathway + +[Term] +id: GO:1902661 +name: positive regulation of glucose mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucose mediated signaling pathway." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24277933] +synonym: "activation of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "positive regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "up regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902659 ! regulation of glucose mediated signaling pathway +relationship: positively_regulates GO:0010255 ! glucose mediated signaling pathway + +[Term] +id: GO:1902662 +name: regulation of peptidyl-L-cysteine S-palmitoylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] +synonym: "regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +is_a: GO:1903059 ! regulation of protein lipidation +relationship: regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation + +[Term] +id: GO:1902663 +name: negative regulation of peptidyl-L-cysteine S-palmitoylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] +synonym: "down regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "negative regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation +is_a: GO:1903060 ! negative regulation of protein lipidation +relationship: negatively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation + +[Term] +id: GO:1902664 +name: positive regulation of peptidyl-L-cysteine S-palmitoylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptidyl-L-cysteine S-palmitoylation." [GO_REF:0000058, GOC:TermGenie, PMID:23444136] +synonym: "activation of peptidyl-cysteine S-palmitoylation" NARROW [GOC:TermGenie] +synonym: "activation of peptidyl-L-cysteine S-palmitoylation" NARROW [GOC:TermGenie] +synonym: "activation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "activation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "activation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "activation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" NARROW [GOC:TermGenie] +synonym: "positive regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-L-cysteine S-palmitoylation" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [GOC:TermGenie] +is_a: GO:1902662 ! regulation of peptidyl-L-cysteine S-palmitoylation +is_a: GO:1903061 ! positive regulation of protein lipidation +relationship: positively_regulates GO:0018230 ! peptidyl-L-cysteine S-palmitoylation + +[Term] +id: GO:1902665 +name: response to isobutanol +namespace: biological_process +alt_id: GO:1990337 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:24014527] +synonym: "process resulting in tolerance to isobutanol" NARROW [] +synonym: "response to 2-methylpropan-1-ol" EXACT [GOC:mengo_curators] +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:1902666 +name: obsolete protein localization to Mmi1 nuclear focus complex +namespace: biological_process +def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex." [GO_REF:0000087, GOC:TermGenie, PMID:23980030] +comment: This term was obsoleted because there is no evidence that this process exists (no factor mediates the localization of proteins to Mmi1 nuclear foci) +synonym: "protein localisation in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] +synonym: "protein localisation to Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] +synonym: "protein localization in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902667 +name: regulation of axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] +synonym: "regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "regulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0050920 ! regulation of chemotaxis +is_a: GO:0051270 ! regulation of cellular component movement +relationship: regulates GO:0007411 ! axon guidance + +[Term] +id: GO:1902668 +name: negative regulation of axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] +synonym: "down regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "down regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "down regulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "down-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "down-regulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "downregulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "downregulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "downregulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "inhibition of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "inhibition of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of axon pathfinding" NARROW [GOC:TermGenie] +synonym: "negative regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "negative regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "negative regulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1902667 ! regulation of axon guidance +relationship: negatively_regulates GO:0007411 ! axon guidance + +[Term] +id: GO:1902669 +name: positive regulation of axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axon guidance." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:23006775] +synonym: "activation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "activation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "activation of axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of axon pathfinding" NARROW [GOC:TermGenie] +synonym: "positive regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "positive regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "positive regulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "up regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "up regulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "up-regulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "up-regulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of axon pathfinding" EXACT [GOC:TermGenie] +synonym: "upregulation of axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "upregulation of axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "upregulation of axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1902667 ! regulation of axon guidance +relationship: positively_regulates GO:0007411 ! axon guidance + +[Term] +id: GO:1902670 +name: carbon dioxide binding +namespace: molecular_function +def: "Binding to carbon dioxide." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:15491402] +synonym: "CO2 binding" EXACT [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1902671 +name: left anterior basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of left anterior cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left anterior flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left anterior cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left anterior flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left anterior cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left anterior flagellum" EXACT [GOC:TermGenie] +synonym: "left anterior flagellum ciliary basal body" EXACT [] +synonym: "microtubule basal body of left anterior cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left anterior flagellum" EXACT [GOC:TermGenie] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097554 ! left anterior flagellum + +[Term] +id: GO:1902672 +name: right anterior basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of right anterior cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right anterior flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right anterior cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right anterior flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right anterior cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right anterior flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right anterior cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right anterior flagellum" EXACT [GOC:TermGenie] +synonym: "right anterior flagellum ciliary basal body" EXACT [] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097555 ! right anterior flagellum + +[Term] +id: GO:1902673 +name: left posteriolateral basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "left posteriolateral flagellum ciliary basal body" EXACT [] +synonym: "microtubule basal body of left posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left posterolateral flagellum" EXACT [GOC:TermGenie] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097556 ! left posteriolateral flagellum + +[Term] +id: GO:1902674 +name: right posteriolateral basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right posteriolateral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right posteriolateral flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right posterolateral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right posterolateral flagellum" EXACT [GOC:TermGenie] +synonym: "right posteriolateral flagellum ciliary basal body" EXACT [] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097557 ! right posteriolateral flagellum + +[Term] +id: GO:1902675 +name: left ventral basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of left ventral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left ventral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left ventral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left ventral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left ventral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left ventral flagellum" EXACT [GOC:TermGenie] +synonym: "left ventral flagellum ciliary basal body" EXACT [] +synonym: "microtubule basal body of left ventral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left ventral flagellum" EXACT [GOC:TermGenie] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097558 ! left ventral flagellum + +[Term] +id: GO:1902676 +name: right ventral basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of right ventral cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right ventral flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right ventral cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right ventral flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right ventral cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right ventral flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right ventral cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right ventral flagellum" EXACT [GOC:TermGenie] +synonym: "right ventral flagellum ciliary basal body" EXACT [] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097559 ! right ventral flagellum + +[Term] +id: GO:1902677 +name: left caudal basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of left caudal cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of left caudal flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left caudal cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of left caudal flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left caudal cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of left caudal flagellum" EXACT [GOC:TermGenie] +synonym: "left caudal flagellum ciliary basal body" EXACT [] +synonym: "microtubule basal body of left caudal cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of left caudal flagellum" EXACT [GOC:TermGenie] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097560 ! left caudal flagellum + +[Term] +id: GO:1902678 +name: right caudal basal body +namespace: cellular_component +def: "Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage)." [GO_REF:0000064, GOC:giardia, GOC:TermGenie, ISBN:9780124260207, PMID:16607022, PMID:5961344] +comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. +synonym: "cilial basal body of right caudal cilium" EXACT [GOC:TermGenie] +synonym: "cilial basal body of right caudal flagellum" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right caudal cilium" EXACT [GOC:TermGenie] +synonym: "ciliary basal body of right caudal flagellum" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right caudal cilium" EXACT [GOC:TermGenie] +synonym: "cilium basal body of right caudal flagellum" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right caudal cilium" EXACT [GOC:TermGenie] +synonym: "microtubule basal body of right caudal flagellum" EXACT [GOC:TermGenie] +synonym: "right caudal flagellum ciliary basal body" EXACT [] +is_a: GO:0036064 ! ciliary basal body +relationship: part_of GO:0097561 ! right caudal flagellum + +[Term] +id: GO:1902679 +name: negative regulation of RNA biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] +synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:2001141 ! regulation of RNA biosynthetic process +relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:1902680 +name: positive regulation of RNA biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] +synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] +synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of RNA formation" NARROW [GOC:TermGenie] +synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:2001141 ! regulation of RNA biosynthetic process +relationship: positively_regulates GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:1902681 +name: regulation of replication fork arrest at rDNA repeats +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats." [GO_REF:0000058, GOC:TermGenie, PMID:23260662] +synonym: "regulation of replication fork arrest at ribosomal DNA repeats" EXACT [GOC:TermGenie] +synonym: "regulation of replication fork blocking at rDNA repeats" EXACT [GOC:TermGenie] +is_a: GO:0033044 ! regulation of chromosome organization +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0031582 ! replication fork arrest at rDNA repeats + +[Term] +id: GO:1902682 +name: protein localization to pericentric heterochromatin +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in the pericentric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20211136] +synonym: "protein localisation in centromeric heterochromatin" EXACT [GOC:TermGenie] +is_a: GO:0071459 ! protein localization to chromosome, centromeric region +is_a: GO:0097355 ! protein localization to heterochromatin + +[Term] +id: GO:1902683 +name: regulation of receptor localization to synapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] +synonym: "regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0097120 ! receptor localization to synapse + +[Term] +id: GO:1902684 +name: negative regulation of receptor localization to synapse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] +synonym: "down regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor localization to synapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor localization to synapse" EXACT [GOC:TermGenie] +synonym: "inhibition of receptor localisation to synapse" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor localization to synapse" NARROW [GOC:TermGenie] +synonym: "negative regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1902683 ! regulation of receptor localization to synapse +relationship: negatively_regulates GO:0097120 ! receptor localization to synapse + +[Term] +id: GO:1902685 +name: positive regulation of receptor localization to synapse +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor localization to synapse." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22252129] +synonym: "activation of receptor localisation to synapse" NARROW [GOC:TermGenie] +synonym: "activation of receptor localization to synapse" NARROW [GOC:TermGenie] +synonym: "positive regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor localization to synapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor localization to synapse" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor localisation to synapse" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor localization to synapse" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1902683 ! regulation of receptor localization to synapse +relationship: positively_regulates GO:0097120 ! receptor localization to synapse + +[Term] +id: GO:1902686 +name: mitochondrial outer membrane permeabilization involved in programmed cell death +namespace: biological_process +def: "The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie, PMID:20151314] +synonym: "mitochondrial membrane permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in PCD" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeability transition involved in regulated cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in PCD" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial membrane permeabilization involved in regulated cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrial outer membrane permeabilization during programmed cell death" EXACT [] +synonym: "mitochondrial permeability transition involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in PCD" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in programmed cell death" NARROW [GOC:TermGenie] +synonym: "mitochondrial permeability transition involved in regulated cell death" RELATED [GOC:TermGenie] +synonym: "mitochondrion outer membrane permeabilization involved in programmed cell death" EXACT [] +synonym: "MPT involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "MPT involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "MPT involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "MPT involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "MPT involved in PCD" NARROW [GOC:TermGenie] +synonym: "MPT involved in programmed cell death" NARROW [GOC:TermGenie] +synonym: "MPT involved in regulated cell death" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in PCD" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitochondrial membrane permeability involved in programmed cell death" EXACT [] +synonym: "positive regulation of mitochondrial membrane permeability involved in regulated cell death" RELATED [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis" RELATED [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death" NARROW [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in PCD" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in programmed cell death" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport across mitochondrial membrane involved in regulated cell death" RELATED [GOC:TermGenie] +is_a: GO:0035794 ! positive regulation of mitochondrial membrane permeability +relationship: part_of GO:0012501 ! programmed cell death + +[Term] +id: GO:1902687 +name: glucosidase complex +namespace: cellular_component +def: "A protein complex which is capable of glucosidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23826932] +comment: An example of this is ygjK in E. coli (P42592) in PMID:23826932. +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1902688 +name: regulation of NAD metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] +synonym: "regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0019674 ! NAD metabolic process + +[Term] +id: GO:1902689 +name: negative regulation of NAD metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] +synonym: "down regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "down regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "down-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "downregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of NAD (oxidized) metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of NAD metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of NAD metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidized NAD metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidized NAD metabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:1902688 ! regulation of NAD metabolic process +relationship: negatively_regulates GO:0019674 ! NAD metabolic process + +[Term] +id: GO:1902690 +name: positive regulation of NAD metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NAD metabolic process." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:19846558] +synonym: "activation of NAD (oxidized) metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of NAD (oxidized) metabolism" NARROW [GOC:TermGenie] +synonym: "activation of NAD metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of NAD metabolism" NARROW [GOC:TermGenie] +synonym: "activation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "activation of oxidized NAD metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of oxidized NAD metabolism" NARROW [GOC:TermGenie] +synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of oxidized nicotinamide adenine dinucleotide metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "up regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "up-regulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD (oxidized) metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD (oxidized) metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of NAD phosphorylation and dephosphorylation" NARROW [GOC:TermGenie] +synonym: "upregulation of nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidized NAD metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidized NAD metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidized nicotinamide adenine dinucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:1902688 ! regulation of NAD metabolic process +relationship: positively_regulates GO:0019674 ! NAD metabolic process + +[Term] +id: GO:1902691 +name: respiratory basal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell." [GO_REF:0000086, GOC:TermGenie, MP:0011114, PMID:17909629] +comment: Changes in the lineage choice of ABCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders +synonym: "airway basal cell differentiation" EXACT [MP:0011114] +is_a: GO:0030855 ! epithelial cell differentiation +is_a: GO:0048863 ! stem cell differentiation + +[Term] +id: GO:1902692 +name: regulation of neuroblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuroblast proliferation." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:21168496] +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: regulates GO:0007405 ! neuroblast proliferation + +[Term] +id: GO:1902693 +name: superoxide dismutase complex +namespace: cellular_component +def: "A protein complex which is capable of superoxide dismutase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10026301] +comment: An example of this is SOD1 in Saccharomyces cerevisiae S288c (UniProt symbol P00445) in PMID:10026301. +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1902694 +name: superoxide dismutase copper chaperone complex +namespace: cellular_component +def: "A protein complex which is capable of superoxide dismutase copper chaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947] +comment: An example of this is CCS1 in Saccharomyces cerevisiae S288c (UniProt symbol P40202) in PMID:10426947. +is_a: GO:1902695 ! metallochaperone complex + +[Term] +id: GO:1902695 +name: metallochaperone complex +namespace: cellular_component +def: "A protein complex which is capable of metallochaperone activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10426947] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1902696 +name: glycine catabolic process to isobutanol +namespace: biological_process +alt_id: GO:1990293 +def: "The chemical reactions and pathways resulting in the breakdown of glycine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:23642236] +synonym: "glycine breakdown to isobutanol" EXACT [GOC:TermGenie] +synonym: "glycine catabolism to isobutanol" EXACT [GOC:TermGenie] +synonym: "glycine degradation to isobutanol" EXACT [GOC:TermGenie] +is_a: GO:0006546 ! glycine catabolic process +is_a: GO:1901960 ! isobutanol metabolic process + +[Term] +id: GO:1902697 +name: valine catabolic process to isobutanol +namespace: biological_process +alt_id: GO:1990292 +def: "The chemical reactions and pathways resulting in the breakdown of valine to isobutanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:9748245] +synonym: "valine breakdown to isobutanol" EXACT [GOC:TermGenie] +synonym: "valine catabolism to isobutanol" EXACT [GOC:TermGenie] +synonym: "valine degradation to isobutanol" EXACT [GOC:TermGenie] +is_a: GO:0006574 ! valine catabolic process +is_a: GO:1901960 ! isobutanol metabolic process + +[Term] +id: GO:1902698 +name: pentose catabolic process to butyrate +namespace: biological_process +alt_id: GO:1990288 +def: "The chemical reactions and pathways resulting in the breakdown of pentose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "acidogenesis" BROAD [GOC:tt] +synonym: "pentose breakdown to butyrate" EXACT [GOC:TermGenie] +synonym: "pentose catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "pentose degradation to butyrate" EXACT [GOC:TermGenie] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:1902699 +name: pentose catabolic process to acetate +namespace: biological_process +alt_id: GO:1990289 +def: "The chemical reactions and pathways resulting in the breakdown of pentose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "acidogenesis" BROAD [GOC:tt] +synonym: "pentose breakdown to acetate" EXACT [GOC:TermGenie] +synonym: "pentose catabolism to acetate" EXACT [GOC:TermGenie] +synonym: "pentose degradation to acetate" EXACT [GOC:TermGenie] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0019323 ! pentose catabolic process + +[Term] +id: GO:1902700 +name: pentose catabolic process to butan-1-ol +namespace: biological_process +alt_id: GO:1990290 +def: "The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "pentose breakdown to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "pentose catabolic process to 1-butanol" EXACT [GOC:tt] +synonym: "pentose catabolic process to butanol" EXACT [GOC:tt] +synonym: "pentose catabolism to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "pentose degradation to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "solventogenesis" BROAD [GOC:tt] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:0071270 ! 1-butanol metabolic process + +[Term] +id: GO:1902701 +name: pentose catabolic process to propan-2-ol +namespace: biological_process +alt_id: GO:1990291 +def: "The chemical reactions and pathways resulting in the breakdown of pentose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "pentose breakdown to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "pentose catabolic process to isopropanol" EXACT [GOC:tt] +synonym: "pentose catabolic process to isopropyl alcohol" EXACT [GOC:tt] +synonym: "pentose catabolism to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "pentose degradation to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "solventogenesis" BROAD [GOC:tt] +is_a: GO:0019323 ! pentose catabolic process +is_a: GO:1902639 ! propan-2-ol metabolic process + +[Term] +id: GO:1902702 +name: hexose catabolic process to propan-2-ol +namespace: biological_process +alt_id: GO:1990283 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "hexose breakdown to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "hexose catabolic process to isopropanol" EXACT [GOC:tt] +synonym: "hexose catabolic process to isopropyl alcohol" EXACT [GOC:tt] +synonym: "hexose catabolism to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "hexose degradation to propan-2-ol" EXACT [GOC:TermGenie] +synonym: "solventogenesis" RELATED [GOC:tt] +is_a: GO:0019320 ! hexose catabolic process +is_a: GO:1902639 ! propan-2-ol metabolic process + +[Term] +id: GO:1902703 +name: hexose catabolic process to butan-1-ol +namespace: biological_process +alt_id: GO:1990284 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to butan-1-ol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "hexose breakdown to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "hexose catabolic process to 1-butanol" EXACT [GOC:tt] +synonym: "hexose catabolic process to butanol" EXACT [GOC:tt] +synonym: "hexose catabolism to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "hexose degradation to butan-1-ol" EXACT [GOC:TermGenie] +synonym: "solventogenesis" BROAD [GOC:tt] +is_a: GO:0019320 ! hexose catabolic process +is_a: GO:0071270 ! 1-butanol metabolic process + +[Term] +id: GO:1902704 +name: hexose catabolic process to acetone +namespace: biological_process +alt_id: GO:1990285 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetone." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "hexose breakdown to acetone" EXACT [GOC:TermGenie] +synonym: "hexose catabolic process to 2-propanone" EXACT [GOC:tt] +synonym: "hexose catabolism to acetone" EXACT [GOC:TermGenie] +synonym: "hexose degradation to acetone" EXACT [GOC:TermGenie] +synonym: "solventogenesis" BROAD [GOC:tt] +is_a: GO:0019320 ! hexose catabolic process +is_a: GO:0043443 ! acetone metabolic process + +[Term] +id: GO:1902705 +name: hexose catabolic process to butyrate +namespace: biological_process +alt_id: GO:1990287 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to butyrate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "acidogenesis" BROAD [GOC:tt] +synonym: "hexose breakdown to butyrate" EXACT [GOC:TermGenie] +synonym: "hexose catabolism to butyrate" EXACT [GOC:TermGenie] +synonym: "hexose degradation to butyrate" EXACT [GOC:TermGenie] +is_a: GO:0019320 ! hexose catabolic process +is_a: GO:0019605 ! butyrate metabolic process + +[Term] +id: GO:1902706 +name: hexose catabolic process to acetate +namespace: biological_process +alt_id: GO:1990286 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to acetate." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "acidogenesis" BROAD [GOC:tt] +synonym: "hexose breakdown to acetate" EXACT [GOC:TermGenie] +synonym: "hexose catabolism to acetate" EXACT [GOC:TermGenie] +synonym: "hexose degradation to acetate" EXACT [GOC:TermGenie] +is_a: GO:0006083 ! acetate metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:1902707 +name: hexose catabolic process to ethanol +namespace: biological_process +alt_id: GO:1990282 +def: "The chemical reactions and pathways resulting in the breakdown of hexose to ethanol." [GO_REF:0000093, GOC:mengo_curators, GOC:TermGenie, PMID:18727018, PMID:19539744] +synonym: "hexose breakdown to ethanol" EXACT [GOC:TermGenie] +synonym: "hexose catabolism to ethanol" EXACT [GOC:TermGenie] +synonym: "hexose degradation to ethanol" EXACT [GOC:TermGenie] +synonym: "solventogenesis" BROAD [GOC:tt] +is_a: GO:0006067 ! ethanol metabolic process +is_a: GO:0019320 ! hexose catabolic process + +[Term] +id: GO:1902708 +name: response to plumbagin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1902709 +name: cellular response to plumbagin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1902708 ! response to plumbagin + +[Term] +id: GO:1902710 +name: GABA receptor complex +namespace: cellular_component +def: "A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] +synonym: "gamma-aminobutyric acid receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1902711 +name: GABA-A receptor complex +namespace: cellular_component +def: "A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor)." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] +comment: An example of this is GBRA1 in human (UniProt symbol P14867) in PMID:18790874. +is_a: GO:1902710 ! GABA receptor complex + +[Term] +id: GO:1902712 +name: G protein-coupled GABA receptor complex +namespace: cellular_component +def: "A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874] +comment: An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874. +synonym: "G-protein coupled GABA receptor complex" EXACT [] +is_a: GO:0038037 ! G protein-coupled receptor dimeric complex +is_a: GO:1902710 ! GABA receptor complex + +[Term] +id: GO:1902716 +name: cell cortex of growing cell tip +namespace: cellular_component +def: "Any cell cortex that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:24146635] +synonym: "cell cortex of growing cell end" EXACT [] +is_a: GO:0051285 ! cell cortex of cell tip +relationship: part_of GO:0035838 ! growing cell tip + +[Term] +id: GO:1902717 +name: obsolete sequestering of iron ion +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of iron ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "sequestering of iron ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1902718 +name: obsolete sequestering of copper ion +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of sequestering of copper ion." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "sequestering of copper ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1902719 +name: obsolete extracellular sequestering of copper ion +namespace: biological_process +def: "OBSOLETE. The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "extracellular sequestering of copper ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1902720 +name: obsolete intracellular sequestering of copper ion +namespace: biological_process +def: "OBSOLETE. The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system." [GO_REF:0000058, GOC:TermGenie, PMID:3099306] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "intracellular sequestering of copper ion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1902721 +name: negative regulation of prolactin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] +synonym: "down regulation of prolactin secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of prolactin secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of prolactin secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of prolactin secretion" NARROW [GOC:TermGenie] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +relationship: negatively_regulates GO:0070459 ! prolactin secretion + +[Term] +id: GO:1902722 +name: positive regulation of prolactin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of prolactin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:16159377] +synonym: "activation of prolactin secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of prolactin secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of prolactin secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of prolactin secretion" EXACT [GOC:TermGenie] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +relationship: positively_regulates GO:0070459 ! prolactin secretion + +[Term] +id: GO:1902723 +name: negative regulation of skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "down regulation of satellite cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of satellite cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of satellite cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation +is_a: GO:0014859 ! negative regulation of skeletal muscle cell proliferation +relationship: negatively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation + +[Term] +id: GO:1902724 +name: positive regulation of skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "activation of satellite cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of satellite cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of satellite cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of satellite cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation +is_a: GO:0014858 ! positive regulation of skeletal muscle cell proliferation +relationship: positively_regulates GO:0014841 ! skeletal muscle satellite cell proliferation + +[Term] +id: GO:1902725 +name: negative regulation of satellite cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "down regulation of satellite cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of satellite cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of satellite cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation +relationship: negatively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation + +[Term] +id: GO:1902726 +name: positive regulation of skeletal muscle satellite cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of satellite cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "activation of satellite cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of satellite cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of satellite cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of satellite cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation +relationship: positively_regulates GO:0014816 ! skeletal muscle satellite cell differentiation + +[Term] +id: GO:1902727 +name: negative regulation of growth factor dependent skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +is_a: GO:1902723 ! negative regulation of skeletal muscle satellite cell proliferation + +[Term] +id: GO:1902728 +name: positive regulation of growth factor dependent skeletal muscle satellite cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +is_a: GO:1902724 ! positive regulation of skeletal muscle satellite cell proliferation + +[Term] +id: GO:1902729 +name: negative regulation of proteoglycan biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "down regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "down regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "downregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of proteoglycan anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of proteoglycan biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of proteoglycan formation" NARROW [GOC:TermGenie] +synonym: "inhibition of proteoglycan synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010561 ! negative regulation of glycoprotein biosynthetic process +relationship: negatively_regulates GO:0030166 ! proteoglycan biosynthetic process + +[Term] +id: GO:1902730 +name: positive regulation of proteoglycan biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "activation of proteoglycan anabolism" NARROW [GOC:TermGenie] +synonym: "activation of proteoglycan biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of proteoglycan biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of proteoglycan formation" NARROW [GOC:TermGenie] +synonym: "activation of proteoglycan synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "up regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of proteoglycan anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of proteoglycan biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of proteoglycan biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of proteoglycan formation" EXACT [GOC:TermGenie] +synonym: "upregulation of proteoglycan synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +relationship: positively_regulates GO:0030166 ! proteoglycan biosynthetic process + +[Term] +id: GO:1902731 +name: negative regulation of chondrocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "down regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of cartilage cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of chondrocyte cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of chondrocyte proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +relationship: negatively_regulates GO:0035988 ! chondrocyte proliferation + +[Term] +id: GO:1902732 +name: positive regulation of chondrocyte proliferation +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +synonym: "activation of cartilage cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of chondrocyte cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of chondrocyte proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of cartilage cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of chondrocyte cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of chondrocyte proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +relationship: positively_regulates GO:0035988 ! chondrocyte proliferation + +[Term] +id: GO:1902733 +name: regulation of growth plate cartilage chondrocyte differentiation +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:23212449] +is_a: GO:1902738 ! regulation of chondrocyte differentiation involved in endochondral bone morphogenesis +relationship: regulates GO:0003418 ! growth plate cartilage chondrocyte differentiation + +[Term] +id: GO:1902734 +name: regulation of receptor-mediated virion attachment to host cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] +synonym: "regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:1903900 ! regulation of viral life cycle +relationship: regulates GO:0046813 ! receptor-mediated virion attachment to host cell + +[Term] +id: GO:1902735 +name: negative regulation of receptor-mediated virion attachment to host cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] +synonym: "down regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "down regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "downregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "inhibition of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie] +synonym: "inhibition of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie] +synonym: "negative regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell +relationship: negatively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell + +[Term] +id: GO:1902736 +name: positive regulation of receptor-mediated virion attachment to host cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18385238] +synonym: "activation of receptor-mediated virion attachment to host cell" NARROW [GOC:TermGenie] +synonym: "activation of virion attachment, binding of host cell surface receptor" NARROW [GOC:TermGenie] +synonym: "positive regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "up regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor-mediated virion attachment to host cell" EXACT [GOC:TermGenie] +synonym: "upregulation of virion attachment, binding of host cell surface receptor" EXACT [GOC:TermGenie] +is_a: GO:1902734 ! regulation of receptor-mediated virion attachment to host cell +is_a: GO:1903902 ! positive regulation of viral life cycle +relationship: positively_regulates GO:0046813 ! receptor-mediated virion attachment to host cell + +[Term] +id: GO:1902737 +name: dendritic filopodium +namespace: cellular_component +def: "A small, membranous protrusion found primarily on dendritic stretches of developing neurons. May receive synaptic input, and can develop into dendritic spines." [GO_REF:0000064, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24464040, Wikipedia:Dendritic_filopodia] +comment: Dendritic filopodia are generally less-well studied than dendritic spines because their transient nature makes them difficult to detect with traditional microscopy techniques, and because they are sometimes destroyed by sample preparation. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. +synonym: "dendrite filopodium" EXACT [] +is_a: GO:0030175 ! filopodium +is_a: GO:0043005 ! neuron projection +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:1902738 +name: regulation of chondrocyte differentiation involved in endochondral bone morphogenesis +namespace: biological_process +def: "Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GO_REF:0000058, GOC:TermGenie, PMID:8662546] +is_a: GO:0032330 ! regulation of chondrocyte differentiation +is_a: GO:1903010 ! regulation of bone development +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis + +[Term] +id: GO:1902742 +name: apoptotic process involved in development +namespace: biological_process +def: "Any apoptotic process that is involved in anatomical structure development." [GO_REF:0000060, GOC:mtg_apoptosis, GOC:pg, GOC:TermGenie] +synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "apoptotic process involved in anatomical structure development" EXACT [] +synonym: "apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process +relationship: part_of GO:0048856 ! anatomical structure development + +[Term] +id: GO:1902743 +name: regulation of lamellipodium organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: regulates GO:0097581 ! lamellipodium organization + +[Term] +id: GO:1902744 +name: negative regulation of lamellipodium organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] +synonym: "down regulation of lamellipodium organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of lamellipodium organization" EXACT [GOC:TermGenie] +synonym: "downregulation of lamellipodium organization" EXACT [GOC:TermGenie] +synonym: "inhibition of lamellipodium organization" NARROW [GOC:TermGenie] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:1902743 ! regulation of lamellipodium organization +relationship: negatively_regulates GO:0097581 ! lamellipodium organization + +[Term] +id: GO:1902745 +name: positive regulation of lamellipodium organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lamellipodium organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:16054028] +synonym: "activation of lamellipodium organization" NARROW [GOC:TermGenie] +synonym: "up regulation of lamellipodium organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of lamellipodium organization" EXACT [GOC:TermGenie] +synonym: "upregulation of lamellipodium organization" EXACT [GOC:TermGenie] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:1902743 ! regulation of lamellipodium organization +relationship: positively_regulates GO:0097581 ! lamellipodium organization + +[Term] +id: GO:1902746 +name: regulation of lens fiber cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] +synonym: "regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0070306 ! lens fiber cell differentiation + +[Term] +id: GO:1902747 +name: negative regulation of lens fiber cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] +synonym: "down regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of lens fiber cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of lens fibre cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902746 ! regulation of lens fiber cell differentiation +relationship: negatively_regulates GO:0070306 ! lens fiber cell differentiation + +[Term] +id: GO:1902748 +name: positive regulation of lens fiber cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17592637] +synonym: "activation of lens fiber cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of lens fibre cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of lens fiber cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of lens fibre cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902746 ! regulation of lens fiber cell differentiation +relationship: positively_regulates GO:0070306 ! lens fiber cell differentiation + +[Term] +id: GO:1902749 +name: regulation of cell cycle G2/M phase transition +namespace: biological_process +def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: regulates GO:0044839 ! cell cycle G2/M phase transition + +[Term] +id: GO:1902750 +name: negative regulation of cell cycle G2/M phase transition +namespace: biological_process +def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] +synonym: "down regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +synonym: "inhibition of cell cycle G2/M phase transition" NARROW [GOC:TermGenie] +is_a: GO:1901988 ! negative regulation of cell cycle phase transition +is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition +relationship: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition + +[Term] +id: GO:1902751 +name: positive regulation of cell cycle G2/M phase transition +namespace: biological_process +def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle." [GO_REF:0000058, GOC:jl, GOC:TermGenie] +synonym: "activation of cell cycle G2/M phase transition" NARROW [GOC:TermGenie] +synonym: "up regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition +relationship: positively_regulates GO:0044839 ! cell cycle G2/M phase transition + +[Term] +id: GO:1902752 +name: regulation of renal amino acid absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:1990297 ! renal amino acid absorption + +[Term] +id: GO:1902753 +name: negative regulation of renal amino acid absorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] +synonym: "down regulation of renal amino acid absorption" EXACT [GOC:TermGenie] +synonym: "down-regulation of renal amino acid absorption" EXACT [GOC:TermGenie] +synonym: "downregulation of renal amino acid absorption" EXACT [GOC:TermGenie] +synonym: "inhibition of renal amino acid absorption" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902752 ! regulation of renal amino acid absorption +relationship: negatively_regulates GO:1990297 ! renal amino acid absorption + +[Term] +id: GO:1902754 +name: positive regulation of renal amino acid absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of renal amino acid absorption." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:1526373] +synonym: "activation of renal amino acid absorption" NARROW [GOC:TermGenie] +synonym: "up regulation of renal amino acid absorption" EXACT [GOC:TermGenie] +synonym: "up-regulation of renal amino acid absorption" EXACT [GOC:TermGenie] +synonym: "upregulation of renal amino acid absorption" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902752 ! regulation of renal amino acid absorption +relationship: positively_regulates GO:1990297 ! renal amino acid absorption + +[Term] +id: GO:1902755 +name: sulfurated eukaryotic molybdenum cofactor(2-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600] +synonym: "sulfurated eukaryotic molybdenum cofactor(2-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process + +[Term] +id: GO:1902756 +name: sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:18258600] +synonym: "sulfurated eukaryotic molybdenum cofactor(2-) anabolism" EXACT [GOC:TermGenie] +synonym: "sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis" EXACT [GOC:TermGenie] +synonym: "sulfurated eukaryotic molybdenum cofactor(2-) formation" EXACT [GOC:TermGenie] +synonym: "sulfurated eukaryotic molybdenum cofactor(2-) synthesis" EXACT [GOC:TermGenie] +xref: MetaCyc:PWY-6476 +xref: Reactome:R-HSA-947581 +is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process +is_a: GO:1902755 ! sulfurated eukaryotic molybdenum cofactor(2-) metabolic process + +[Term] +id: GO:1902757 +name: bis(molybdopterin guanine dinucleotide)molybdenum metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] +synonym: "bis(molybdopterin guanine dinucleotide)molybdenum metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process + +[Term] +id: GO:1902758 +name: bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process +namespace: biological_process +alt_id: GO:0061600 +def: "The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] +synonym: "bis(molybdopterin guanine dinucleotide)molybdenum anabolism" EXACT [GOC:TermGenie] +synonym: "bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis" EXACT [GOC:TermGenie] +synonym: "bis(molybdopterin guanine dinucleotide)molybdenum formation" EXACT [GOC:TermGenie] +synonym: "bis(molybdopterin guanine dinucleotide)molybdenum synthesis" EXACT [GOC:TermGenie] +synonym: "bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process" EXACT [] +xref: MetaCyc:PWY-5964 +is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:1902757 ! bis(molybdopterin guanine dinucleotide)molybdenum metabolic process + +[Term] +id: GO:1902759 +name: Mo(VI)-molybdopterin cytosine dinucleotide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] +synonym: "Mo(VI)-molybdopterin cytosine dinucleotide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009117 ! nucleotide metabolic process +is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process + +[Term] +id: GO:1902760 +name: Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process +namespace: biological_process +alt_id: GO:0061601 +def: "The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:23201473] +synonym: "Mo(VI)-molybdopterin cytosine dinucleotide anabolism" EXACT [GOC:TermGenie] +synonym: "Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis" EXACT [GOC:TermGenie] +synonym: "Mo(VI)-molybdopterin cytosine dinucleotide formation" EXACT [GOC:TermGenie] +synonym: "Mo(VI)-molybdopterin cytosine dinucleotide synthesis" EXACT [GOC:TermGenie] +synonym: "Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process" EXACT [] +xref: MetaCyc:PWY-6476 +is_a: GO:0006777 ! Mo-molybdopterin cofactor biosynthetic process +is_a: GO:0009165 ! nucleotide biosynthetic process +is_a: GO:1902759 ! Mo(VI)-molybdopterin cytosine dinucleotide metabolic process + +[Term] +id: GO:1902761 +name: positive regulation of chondrocyte development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chondrocyte development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] +synonym: "activation of chondrocyte development" NARROW [GOC:TermGenie] +synonym: "up regulation of chondrocyte development" EXACT [GOC:TermGenie] +synonym: "up-regulation of chondrocyte development" EXACT [GOC:TermGenie] +synonym: "upregulation of chondrocyte development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0032332 ! positive regulation of chondrocyte differentiation +is_a: GO:0061181 ! regulation of chondrocyte development +relationship: positively_regulates GO:0002063 ! chondrocyte development + +[Term] +id: GO:1902762 +name: regulation of embryonic skeletal joint development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0072498 ! embryonic skeletal joint development + +[Term] +id: GO:1902763 +name: negative regulation of embryonic skeletal joint development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] +synonym: "down regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +synonym: "down-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +synonym: "downregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +synonym: "inhibition of embryonic skeletal joint development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1902762 ! regulation of embryonic skeletal joint development +relationship: negatively_regulates GO:0072498 ! embryonic skeletal joint development + +[Term] +id: GO:1902764 +name: positive regulation of embryonic skeletal joint development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryonic skeletal joint development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16575901] +synonym: "activation of embryonic skeletal joint development" NARROW [GOC:TermGenie] +synonym: "up regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +synonym: "up-regulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +synonym: "upregulation of embryonic skeletal joint development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1902762 ! regulation of embryonic skeletal joint development +relationship: positively_regulates GO:0072498 ! embryonic skeletal joint development + +[Term] +id: GO:1902766 +name: skeletal muscle satellite cell migration +namespace: biological_process +def: "The orderly movement of a skeletal muscle satellite cell from one site to another. Migration of these cells is a key step in the process of growth and repair of skeletal muscle cells." [GO_REF:0000091, GOC:mr, GOC:TermGenie, PMID:17996437, PMID:19609936] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:1902767 +name: isoprenoid biosynthetic process via mevalonate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoprenoid via mevalonate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:11078528] +synonym: "isoprenoid anabolism via mevalonate" EXACT [GOC:TermGenie] +synonym: "isoprenoid biosynthesis via mevalonate" EXACT [GOC:TermGenie] +synonym: "isoprenoid formation via mevalonate" EXACT [GOC:TermGenie] +synonym: "isoprenoid synthesis via mevalonate" EXACT [GOC:TermGenie] +is_a: GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:1902768 +name: isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isoprenoid via 1-deoxy-D-xylulose 5-phosphate." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:23746261] +synonym: "isoprenoid anabolism via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] +synonym: "isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] +synonym: "isoprenoid formation via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] +synonym: "isoprenoid synthesis via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:TermGenie] +is_a: GO:0008299 ! isoprenoid biosynthetic process + +[Term] +id: GO:1902769 +name: regulation of choline O-acetyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] +synonym: "regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1902770 +name: negative regulation of choline O-acetyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] +synonym: "down regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CHOACTase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of choline acetylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of choline acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of choline O-acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity + +[Term] +id: GO:1902771 +name: positive regulation of choline O-acetyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of choline O-acetyltransferase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:7576634] +synonym: "activation of acetyl-CoA:choline O-acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CHOACTase activity" NARROW [GOC:TermGenie] +synonym: "activation of choline acetylase activity" NARROW [GOC:TermGenie] +synonym: "activation of choline acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of choline O-acetyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acetyl-CoA:choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CHOACTase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of choline acetylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of choline acetyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of choline O-acetyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1902769 ! regulation of choline O-acetyltransferase activity + +[Term] +id: GO:1902772 +name: positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signaling pathway +namespace: biological_process +def: "Any positive regulation of phosphorelay signal transduction system that is involved in hydrogen peroxide mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:18406331] +synonym: "activation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of histidyl-aspartyl phosphorelay involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphorelay signal transduction system involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphorelay signal transduction system involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of two-component signal transduction system (phosphorelay) involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "stimulation of two-component signal transduction involved in H2O2 mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "stimulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of two-component signal transduction involved in H2O2 mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of two-component signal transduction involved in hydrogen peroxide mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0070299 ! positive regulation of phosphorelay signal transduction system +relationship: part_of GO:0071588 ! hydrogen peroxide mediated signaling pathway + +[Term] +id: GO:1902773 +name: GTPase activator complex +namespace: cellular_component +def: "A protein complex which is capable of GTPase activator activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187] +comment: An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay). +is_a: GO:0150005 ! enzyme activator complex + +[Term] +id: GO:1902774 +name: late endosome to lysosome transport +namespace: biological_process +def: "The directed movement of substances from late endosome to lysosome." [GO_REF:0000076, GOC:TermGenie, PMID:23949442] +comment: an example of this is snapin in mouse (Q9Z266) in PMID:20920792 inferred from mutant phenotype +synonym: "prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie] +is_a: GO:0007041 ! lysosomal transport + +[Term] +id: GO:1902775 +name: mitochondrial large ribosomal subunit assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit." [GO_REF:0000079, GOC:TermGenie, PMID:24206665] +synonym: "39S ribosomal subunit, mitochondrial assembly" NARROW [GOC:TermGenie] +synonym: "39S ribosomal subunit, mitochondrial formation" NARROW [GOC:TermGenie] +synonym: "mitochondrial large ribosomal subunit formation" EXACT [GOC:TermGenie] +is_a: GO:0000027 ! ribosomal large subunit assembly +relationship: part_of GO:0061668 ! mitochondrial ribosome assembly + +[Term] +id: GO:1902776 +name: 6-sulfoquinovose(1-) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506] +synonym: "6-sulfoquinovose(1-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:1902777 +name: 6-sulfoquinovose(1-) catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-)." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:24463506] +synonym: "6-sulfoquinovose(1-) breakdown" EXACT [GOC:TermGenie] +synonym: "6-sulfoquinovose(1-) catabolism" EXACT [GOC:TermGenie] +synonym: "6-sulfoquinovose(1-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:1902776 ! 6-sulfoquinovose(1-) metabolic process + +[Term] +id: GO:1902778 +name: response to alkane +namespace: biological_process +alt_id: GO:1990373 +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995] +synonym: "process resulting in tolerance to alkane" NARROW [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1902779 +name: cellular response to alkane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739, PMID:23826995] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902780 +name: response to nonane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902781 +name: cellular response to nonane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22958739] +is_a: GO:1902779 ! cellular response to alkane +is_a: GO:1902780 ! response to nonane + +[Term] +id: GO:1902782 +name: response to decane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902783 +name: cellular response to decane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a decane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902779 ! cellular response to alkane +is_a: GO:1902782 ! response to decane + +[Term] +id: GO:1902784 +name: response to undecane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902785 +name: cellular response to undecane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an undecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902779 ! cellular response to alkane +is_a: GO:1902784 ! response to undecane + +[Term] +id: GO:1902786 +name: response to dodecane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902787 +name: cellular response to dodecane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dodecane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:23826995] +is_a: GO:1902779 ! cellular response to alkane +is_a: GO:1902786 ! response to dodecane + +[Term] +id: GO:1902788 +name: response to isooctane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] +is_a: GO:1902778 ! response to alkane + +[Term] +id: GO:1902789 +name: cellular response to isooctane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isooctane stimulus." [GO_REF:0000071, GOC:mengo_curators, GOC:TermGenie, PMID:22328008] +is_a: GO:1902779 ! cellular response to alkane +is_a: GO:1902788 ! response to isooctane + +[Term] +id: GO:1902790 +name: undecan-2-one metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559] +synonym: "undecan-2-one metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042180 ! cellular ketone metabolic process + +[Term] +id: GO:1902791 +name: undecan-2-one biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of undecan-2-one." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:4950559] +synonym: "undecan-2-one anabolism" EXACT [GOC:TermGenie] +synonym: "undecan-2-one biosynthesis" EXACT [GOC:TermGenie] +synonym: "undecan-2-one formation" EXACT [GOC:TermGenie] +synonym: "undecan-2-one synthesis" EXACT [GOC:TermGenie] +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1902790 ! undecan-2-one metabolic process + +[Term] +id: GO:1902792 +name: pyrroline-5-carboxylate reductase complex +namespace: cellular_component +def: "A protein complex which is capable of pyrroline-5-carboxylate reductase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:2722838] +comment: An example of this is PYCR1 in human (P32322) in PMID:2722838 (inferred from direct assay). +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1902793 +name: glutamate decarboxylase complex +namespace: cellular_component +def: "A protein complex which is capable of glutamate decarboxylase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17384644] +comment: An example of this is GAD1 in human (Q99259) in PMID:17384644 (inferred from direct assay). +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1902794 +name: siRNA-independent facultative heterochromatin assembly +namespace: biological_process +def: "The assembly of facultative heterochromatin to form a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process independent of small interfering RNAs." [GO_REF:0000079, GOC:TermGenie, PMID:22144463, PMID:24210919] +synonym: "heterochromatin island assembly" EXACT [] +synonym: "heterochromatin island formation" EXACT [GOC:TermGenie] +is_a: GO:0140718 ! facultative heterochromatin assembly + +[Term] +id: GO:1902795 +name: siRNA-dependent facultative heterochromatin assembly +namespace: biological_process +def: "The assembly of facultative heterochromatin to form a heterochromatin domain, enriched in histone H3 methylated on lysine 9 (H3K9me), by a process mediated by a small interfering RNA." [GO_REF:0000079, GOC:TermGenie, PMID:23151475, PMID:24210919] +synonym: "heterochromatin domain assembly" EXACT [] +synonym: "heterochromatin domain formation" EXACT [GOC:TermGenie] +synonym: "HOOD assembly" EXACT [GOC:TermGenie] +synonym: "HOOD formation" EXACT [GOC:TermGenie] +is_a: GO:0031048 ! heterochromatin assembly by small RNA +is_a: GO:0140718 ! facultative heterochromatin assembly + +[Term] +id: GO:1902796 +name: regulation of snoRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:1903323 ! regulation of snoRNA metabolic process +relationship: regulates GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:1902797 +name: negative regulation of snoRNA processing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] +synonym: "down regulation of snoRNA processing" EXACT [GOC:TermGenie] +synonym: "down-regulation of snoRNA processing" EXACT [GOC:TermGenie] +synonym: "downregulation of snoRNA processing" EXACT [GOC:TermGenie] +synonym: "inhibition of snoRNA processing" NARROW [GOC:TermGenie] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:1902796 ! regulation of snoRNA processing +is_a: GO:1903324 ! negative regulation of snoRNA metabolic process +relationship: negatively_regulates GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:1902798 +name: positive regulation of snoRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of snoRNA processing." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] +synonym: "activation of snoRNA processing" NARROW [GOC:TermGenie] +synonym: "up regulation of snoRNA processing" EXACT [GOC:TermGenie] +synonym: "up-regulation of snoRNA processing" EXACT [GOC:TermGenie] +synonym: "upregulation of snoRNA processing" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:1902796 ! regulation of snoRNA processing +is_a: GO:1903325 ! positive regulation of snoRNA metabolic process +relationship: positively_regulates GO:0043144 ! sno(s)RNA processing + +[Term] +id: GO:1902799 +name: regulation of phosphodiesterase I activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510] +synonym: "regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "regulation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PDE I activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphodiesterase activity" BROAD [GOC:TermGenie] +is_a: GO:1905777 ! regulation of exonuclease activity + +[Term] +id: GO:1902800 +name: positive regulation of phosphodiesterase I activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase I activity." [GO_REF:0000059, GOC:TermGenie, PMID:24559510] +synonym: "activation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" NARROW [GOC:TermGenie] +synonym: "activation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "activation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "activation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "activation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "activation of nucleotide pyrophosphatase/phosphodiesterase I activity" NARROW [GOC:TermGenie] +synonym: "activation of oligonucleate 5'-nucleotidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of orthophosphoric diester phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of PDE I activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphodiesterase I activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PDE I activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "up regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "up regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "up regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PDE I activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PDE I activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5'-exonuclease activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'-NPDase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'-nucleotide phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'-PDase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'-PDE activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'-phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5'NPDE activity" RELATED [GOC:TermGenie] +synonym: "upregulation of alkaline phosphodiesterase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of exonuclease I activity" RELATED [GOC:TermGenie] +synonym: "upregulation of nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [GOC:TermGenie] +synonym: "upregulation of oligonucleate 5'-nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of orthophosphoric diester phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PDE I activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphodiesterase I activity" EXACT [GOC:TermGenie] +is_a: GO:1902799 ! regulation of phosphodiesterase I activity +is_a: GO:1905779 ! positive regulation of exonuclease activity + +[Term] +id: GO:1902801 +name: regulation of siRNA-independent facultative heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of siRNA-independent facultative heterochromatin assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] +synonym: "regulation of heterochromatin island assembly" EXACT [] +synonym: "regulation of heterochromatin island formation" EXACT [GOC:TermGenie] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:1902794 ! siRNA-independent facultative heterochromatin assembly + +[Term] +id: GO:1902802 +name: regulation of siRNA-dependent facultative heterochromatin assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of siRNA-dependent facultative heterochromatin assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24210919] +synonym: "regulation of heterochromatin domain assembly" EXACT [] +synonym: "regulation of heterochromatin domain formation" EXACT [GOC:TermGenie] +synonym: "regulation of HOOD assembly" EXACT [GOC:TermGenie] +synonym: "regulation of HOOD formation" EXACT [GOC:TermGenie] +is_a: GO:0010964 ! regulation of heterochromatin assembly by small RNA +relationship: regulates GO:1902795 ! siRNA-dependent facultative heterochromatin assembly + +[Term] +id: GO:1902803 +name: regulation of synaptic vesicle transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] +synonym: "regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:1902804 +name: negative regulation of synaptic vesicle transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] +synonym: "down regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1902803 ! regulation of synaptic vesicle transport +relationship: negatively_regulates GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:1902805 +name: positive regulation of synaptic vesicle transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23527112] +synonym: "activation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "activation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "activation of synaptic vesicle transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle fission" RELATED [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle fusion" RELATED [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1902803 ! regulation of synaptic vesicle transport +relationship: positively_regulates GO:0048489 ! synaptic vesicle transport + +[Term] +id: GO:1902806 +name: regulation of cell cycle G1/S phase transition +namespace: biological_process +def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +is_a: GO:1901987 ! regulation of cell cycle phase transition +relationship: regulates GO:0044843 ! cell cycle G1/S phase transition + +[Term] +id: GO:1902807 +name: negative regulation of cell cycle G1/S phase transition +namespace: biological_process +def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "down regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +synonym: "downregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +synonym: "inhibition of cell cycle G1/S phase transition" NARROW [GOC:TermGenie] +is_a: GO:1901988 ! negative regulation of cell cycle phase transition +is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition +relationship: negatively_regulates GO:0044843 ! cell cycle G1/S phase transition + +[Term] +id: GO:1902808 +name: positive regulation of cell cycle G1/S phase transition +namespace: biological_process +def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of cell cycle G1/S phase transition" NARROW [GOC:TermGenie] +synonym: "up regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +synonym: "upregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] +is_a: GO:1901989 ! positive regulation of cell cycle phase transition +is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition +relationship: positively_regulates GO:0044843 ! cell cycle G1/S phase transition + +[Term] +id: GO:1902809 +name: regulation of skeletal muscle fiber differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] +is_a: GO:0010830 ! regulation of myotube differentiation +is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation +relationship: regulates GO:0098528 ! skeletal muscle fiber differentiation + +[Term] +id: GO:1902810 +name: negative regulation of skeletal muscle fiber differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] +synonym: "down regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] +is_a: GO:0010832 ! negative regulation of myotube differentiation +is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation +is_a: GO:2001015 ! negative regulation of skeletal muscle cell differentiation +relationship: negatively_regulates GO:0098528 ! skeletal muscle fiber differentiation + +[Term] +id: GO:1902811 +name: positive regulation of skeletal muscle fiber differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17879321] +synonym: "activation of skeletal muscle fiber differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal muscle fiber differentiation" EXACT [GOC:TermGenie] +is_a: GO:0010831 ! positive regulation of myotube differentiation +is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation +is_a: GO:2001016 ! positive regulation of skeletal muscle cell differentiation +relationship: positively_regulates GO:0098528 ! skeletal muscle fiber differentiation + +[Term] +id: GO:1902812 +name: regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] +synonym: "regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +is_a: GO:0030510 ! regulation of BMP signaling pathway +relationship: regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1902813 +name: negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] +synonym: "down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie] +synonym: "inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +is_a: GO:0030514 ! negative regulation of BMP signaling pathway +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +relationship: negatively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1902814 +name: positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10499580] +synonym: "activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" NARROW [GOC:TermGenie] +synonym: "activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" NARROW [GOC:TermGenie] +synonym: "positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:TermGenie] +is_a: GO:0030513 ! positive regulation of BMP signaling pathway +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902812 ! regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry +relationship: positively_regulates GO:0003155 ! BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry + +[Term] +id: GO:1902815 +name: N,N'-diacetylchitobiose import +namespace: biological_process +def: "The directed movement of N,N'-diacetylchitobiose into a cell or organelle." [GO_REF:0000073, GOC:am, GOC:TermGenie, PMID:9405618] +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:1902816 +name: regulation of protein localization to microtubule +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] +synonym: "regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0035372 ! protein localization to microtubule + +[Term] +id: GO:1902817 +name: negative regulation of protein localization to microtubule +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:23087209] +synonym: "down regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to microtubule" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to microtubule" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to microtubule" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to microtubule" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to microtubule" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to microtubule" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to microtubule" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1902816 ! regulation of protein localization to microtubule +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0035372 ! protein localization to microtubule + +[Term] +id: GO:1902818 +name: ethyl acetate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] +synonym: "ethyl acetate metabolism" EXACT [GOC:TermGenie] +synonym: "ethyl ethanoate metabolic process" EXACT [] +is_a: GO:1900619 ! acetate ester metabolic process + +[Term] +id: GO:1902819 +name: ethyl acetate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ethyl acetate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] +synonym: "ethyl acetate anabolism" EXACT [GOC:TermGenie] +synonym: "ethyl acetate biosynthesis" EXACT [GOC:TermGenie] +synonym: "ethyl acetate formation" EXACT [GOC:TermGenie] +synonym: "ethyl acetate synthesis" EXACT [GOC:TermGenie] +synonym: "ethyl ethanoate biosynthetic process" EXACT [] +is_a: GO:1900620 ! acetate ester biosynthetic process +is_a: GO:1902818 ! ethyl acetate metabolic process + +[Term] +id: GO:1902820 +name: 1-undecene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] +synonym: "1-undecene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0043449 ! cellular alkene metabolic process + +[Term] +id: GO:1902821 +name: 1-undecene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-undecene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16013377] +synonym: "1-undecene anabolism" EXACT [GOC:TermGenie] +synonym: "1-undecene biosynthesis" EXACT [GOC:TermGenie] +synonym: "1-undecene formation" EXACT [GOC:TermGenie] +synonym: "1-undecene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0043450 ! alkene biosynthetic process +is_a: GO:1902820 ! 1-undecene metabolic process + +[Term] +id: GO:1902822 +name: regulation of late endosome to lysosome transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] +synonym: "regulation of prevacuolar compartment to lysosome transport" BROAD [GOC:TermGenie] +is_a: GO:1903335 ! regulation of vacuolar transport +relationship: regulates GO:1902774 ! late endosome to lysosome transport + +[Term] +id: GO:1902823 +name: negative regulation of late endosome to lysosome transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] +synonym: "down regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +synonym: "downregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +synonym: "inhibition of late endosome to lysosome transport" NARROW [GOC:TermGenie] +is_a: GO:1902822 ! regulation of late endosome to lysosome transport +is_a: GO:1903336 ! negative regulation of vacuolar transport +relationship: negatively_regulates GO:1902774 ! late endosome to lysosome transport + +[Term] +id: GO:1902824 +name: positive regulation of late endosome to lysosome transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23949442] +synonym: "activation of late endosome to lysosome transport" NARROW [GOC:TermGenie] +synonym: "up regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +synonym: "upregulation of late endosome to lysosome transport" EXACT [GOC:TermGenie] +is_a: GO:1902822 ! regulation of late endosome to lysosome transport +is_a: GO:1903337 ! positive regulation of vacuolar transport +relationship: positively_regulates GO:1902774 ! late endosome to lysosome transport + +[Term] +id: GO:1902829 +name: regulation of spinal cord association neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +synonym: "regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0021527 ! spinal cord association neuron differentiation + +[Term] +id: GO:1902830 +name: negative regulation of spinal cord association neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +synonym: "down regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of spinal cord association neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation +relationship: negatively_regulates GO:0021527 ! spinal cord association neuron differentiation + +[Term] +id: GO:1902831 +name: positive regulation of spinal cord association neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spinal cord association neuron differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +synonym: "activation of spinal cord association neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of spinal cord dorsal interneuron differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of spinal cord association neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of spinal cord dorsal interneuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation +relationship: positively_regulates GO:0021527 ! spinal cord association neuron differentiation + +[Term] +id: GO:1902832 +name: negative regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +synonym: "down regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +synonym: "inhibition of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] +is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord +is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord + +[Term] +id: GO:1902833 +name: positive regulation of cell proliferation in dorsal spinal cord +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in dorsal spinal cord." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +synonym: "activation of cell proliferation in dorsal spinal cord" NARROW [GOC:TermGenie] +synonym: "up regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +synonym: "upregulation of cell proliferation in dorsal spinal cord" EXACT [GOC:TermGenie] +is_a: GO:0021921 ! regulation of cell proliferation in dorsal spinal cord +is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0010456 ! cell proliferation in dorsal spinal cord + +[Term] +id: GO:1902834 +name: regulation of proline import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +synonym: "regulation of proline import into cell" EXACT [] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +relationship: regulates GO:1905647 ! proline import across plasma membrane + +[Term] +id: GO:1902835 +name: negative regulation of proline import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +synonym: "down regulation of proline import into cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of proline import into cell" EXACT [GOC:TermGenie] +synonym: "downregulation of proline import into cell" EXACT [GOC:TermGenie] +synonym: "inhibition of proline import into cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of proline import into cell" EXACT [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1902834 ! regulation of proline import across plasma membrane +relationship: negatively_regulates GO:1905647 ! proline import across plasma membrane + +[Term] +id: GO:1902836 +name: positive regulation of proline import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proline import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +synonym: "activation of proline import into cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of proline import into cell" EXACT [] +synonym: "up regulation of proline import into cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of proline import into cell" EXACT [GOC:TermGenie] +synonym: "upregulation of proline import into cell" EXACT [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1902834 ! regulation of proline import across plasma membrane +relationship: positively_regulates GO:1905647 ! proline import across plasma membrane + +[Term] +id: GO:1902838 +name: regulation of nuclear migration along microtubule +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear movement, microtubule-mediated" BROAD [GOC:TermGenie] +synonym: "regulation of nucleus migration" BROAD [GOC:TermGenie] +synonym: "regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +is_a: GO:1902513 ! regulation of organelle transport along microtubule +relationship: regulates GO:0030473 ! nuclear migration along microtubule + +[Term] +id: GO:1902839 +name: negative regulation of nuclear migration along microtubule +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "down regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "down regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "down regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "down-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "down-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "downregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "downregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "inhibition of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear migration along microtubule" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] +synonym: "inhibition of transport of nucleus by microtubules" NARROW [GOC:TermGenie] +synonym: "inhibition of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] +synonym: "negative regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "negative regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "negative regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1902838 ! regulation of nuclear migration along microtubule +relationship: negatively_regulates GO:0030473 ! nuclear migration along microtubule + +[Term] +id: GO:1902840 +name: positive regulation of nuclear migration along microtubule +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "activation of microtubule cytoskeleton-dependent nuclear positioning" NARROW [GOC:TermGenie] +synonym: "activation of microtubule cytoskeleton-dependent nucleus positioning" NARROW [GOC:TermGenie] +synonym: "activation of microtubule-dependent nuclear positioning" NARROW [GOC:TermGenie] +synonym: "activation of microtubule-dependent nucleus positioning" NARROW [GOC:TermGenie] +synonym: "activation of microtubule-mediated nuclear migration" NARROW [GOC:TermGenie] +synonym: "activation of nuclear migration along microtubule" NARROW [GOC:TermGenie] +synonym: "activation of nuclear migration, microtubule-mediated" NARROW [GOC:TermGenie] +synonym: "activation of transport of nucleus by microtubules" NARROW [GOC:TermGenie] +synonym: "activation of transport of nucleus, microtubule-mediated" NARROW [GOC:TermGenie] +synonym: "positive regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "positive regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "positive regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "up regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "up regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "up-regulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "up-regulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule cytoskeleton-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule cytoskeleton-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule-dependent nuclear positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule-dependent nucleus positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule-mediated nuclear migration" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear migration along microtubule" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear migration, microtubule-mediated" EXACT [GOC:TermGenie] +synonym: "upregulation of transport of nucleus by microtubules" EXACT [GOC:TermGenie] +synonym: "upregulation of transport of nucleus, microtubule-mediated" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1902838 ! regulation of nuclear migration along microtubule +relationship: positively_regulates GO:0030473 ! nuclear migration along microtubule + +[Term] +id: GO:1902841 +name: regulation of netrin-activated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] +synonym: "regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0038007 ! netrin-activated signaling pathway + +[Term] +id: GO:1902842 +name: negative regulation of netrin-activated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] +synonym: "down regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of netrin signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of netrin-activated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of netrin-activated signalling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of netrin-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902841 ! regulation of netrin-activated signaling pathway +relationship: negatively_regulates GO:0038007 ! netrin-activated signaling pathway + +[Term] +id: GO:1902843 +name: positive regulation of netrin-activated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of netrin-activated signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:24004945] +synonym: "activation of netrin signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of netrin-activated signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "activation of netrin-activated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of netrin-activated signalling pathway" NARROW [GOC:TermGenie] +synonym: "activation of netrin-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of netrin signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of netrin-activated signal transduction pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of netrin-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of netrin-activated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of netrin-mediated signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902841 ! regulation of netrin-activated signaling pathway +relationship: positively_regulates GO:0038007 ! netrin-activated signaling pathway + +[Term] +id: GO:1902844 +name: positive regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway +namespace: biological_process +def: "A negative regulation of canonical Wnt signaling pathway that results in positive regulation of spinal cord association neuron differentiation." [GO_REF:0000063, GOC:mr, GOC:TermGenie, PMID:11262869] +synonym: "activation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of spinal cord association neuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of spinal cord dorsal interneuron differentiation by negative regulation of canonical Wnt signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +is_a: GO:1902829 ! regulation of spinal cord association neuron differentiation +relationship: negatively_regulates GO:0100067 ! positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway + +[Term] +id: GO:1902845 +name: negative regulation of mitotic spindle elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "down regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "down regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic spindle elongation" NARROW [GOC:TermGenie] +synonym: "inhibition of spindle elongation during mitosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0032888 ! regulation of mitotic spindle elongation +relationship: negatively_regulates GO:0000022 ! mitotic spindle elongation + +[Term] +id: GO:1902846 +name: positive regulation of mitotic spindle elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "activation of mitotic spindle elongation" NARROW [GOC:TermGenie] +synonym: "activation of spindle elongation during mitosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic spindle elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle elongation during mitosis" EXACT [GOC:TermGenie] +is_a: GO:0032888 ! regulation of mitotic spindle elongation +is_a: GO:0062033 ! positive regulation of mitotic sister chromatid segregation +relationship: positively_regulates GO:0000022 ! mitotic spindle elongation + +[Term] +id: GO:1902847 +name: regulation of neuronal signal transduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0023041 ! neuronal signal transduction + +[Term] +id: GO:1902848 +name: negative regulation of neuronal signal transduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] +synonym: "down regulation of neuronal signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuronal signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of neuronal signal transduction" EXACT [GOC:TermGenie] +synonym: "inhibition of neuronal signal transduction" NARROW [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1902847 ! regulation of neuronal signal transduction +relationship: negatively_regulates GO:0023041 ! neuronal signal transduction + +[Term] +id: GO:1902849 +name: positive regulation of neuronal signal transduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuronal signal transduction." [GO_REF:0000058, GOC:sjp, GOC:TermGenie] +synonym: "activation of neuronal signal transduction" NARROW [GOC:TermGenie] +synonym: "up regulation of neuronal signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuronal signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of neuronal signal transduction" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1902847 ! regulation of neuronal signal transduction +relationship: positively_regulates GO:0023041 ! neuronal signal transduction + +[Term] +id: GO:1902850 +name: microtubule cytoskeleton organization involved in mitosis +namespace: biological_process +def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] +synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] +synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] +synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] +is_a: GO:0000226 ! microtubule cytoskeleton organization +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:1902852 +name: regulation of nuclear migration during mitotic telophase +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +is_a: GO:1902838 ! regulation of nuclear migration along microtubule +relationship: regulates GO:0090561 ! nuclear migration during mitotic telophase + +[Term] +id: GO:1902853 +name: negative regulation of nuclear migration during mitotic telophase +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "down regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +synonym: "inhibition of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie] +is_a: GO:1902839 ! negative regulation of nuclear migration along microtubule +is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase +relationship: negatively_regulates GO:0090561 ! nuclear migration during mitotic telophase + +[Term] +id: GO:1902854 +name: positive regulation of nuclear migration during mitotic telophase +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase." [GO_REF:0000058, GOC:TermGenie, PMID:23087209] +synonym: "activation of nuclear migration during mitotic telophase" NARROW [GOC:TermGenie] +synonym: "up regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear migration during mitotic telophase" EXACT [GOC:TermGenie] +is_a: GO:1902840 ! positive regulation of nuclear migration along microtubule +is_a: GO:1902852 ! regulation of nuclear migration during mitotic telophase +relationship: positively_regulates GO:0090561 ! nuclear migration during mitotic telophase + +[Term] +id: GO:1902855 +name: regulation of non-motile cilium assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] +synonym: "regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "regulation of nonmotile primary cilium assembly" RELATED [] +synonym: "regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +is_a: GO:1902017 ! regulation of cilium assembly +relationship: regulates GO:1905515 ! non-motile cilium assembly + +[Term] +id: GO:1902856 +name: negative regulation of non-motile cilium assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] +synonym: "down regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of immotile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory cilium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of nonmotile primary cilium assembly" RELATED [] +synonym: "negative regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +is_a: GO:1902018 ! negative regulation of cilium assembly +is_a: GO:1902855 ! regulation of non-motile cilium assembly +relationship: negatively_regulates GO:1905515 ! non-motile cilium assembly + +[Term] +id: GO:1902857 +name: positive regulation of non-motile cilium assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of non-motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:23807208] +synonym: "activation of immotile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "activation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "activation of nonmotile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "activation of sensory cilium assembly" NARROW [GOC:TermGenie] +synonym: "activation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of nonmotile primary cilium assembly" RELATED [] +synonym: "positive regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of immotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of nonmotile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of nonmotile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of sensory cilium assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of sensory cilium biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0045724 ! positive regulation of cilium assembly +is_a: GO:1902855 ! regulation of non-motile cilium assembly +relationship: positively_regulates GO:1905515 ! non-motile cilium assembly + +[Term] +id: GO:1902858 +name: propionyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] +synonym: "propionyl-CoA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:1902859 +name: propionyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] +synonym: "propionyl-CoA breakdown" EXACT [GOC:TermGenie] +synonym: "propionyl-CoA catabolism" EXACT [GOC:TermGenie] +synonym: "propionyl-CoA degradation" EXACT [GOC:TermGenie] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:1902858 ! propionyl-CoA metabolic process + +[Term] +id: GO:1902860 +name: propionyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of propionyl-CoA." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:15514053] +synonym: "propionyl-CoA anabolism" EXACT [GOC:TermGenie] +synonym: "propionyl-CoA biosynthesis" EXACT [GOC:TermGenie] +synonym: "propionyl-CoA formation" EXACT [GOC:TermGenie] +synonym: "propionyl-CoA synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0071616 ! acyl-CoA biosynthetic process +is_a: GO:1902858 ! propionyl-CoA metabolic process + +[Term] +id: GO:1902862 +name: obsolete glycerol catabolic process to glycerone phosphate +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glycerol to glycerone phosphate." [GO_REF:0000093, GOC:dph, GOC:TermGenie, ISBN:0201090910] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "glycerol breakdown to glycerone phosphate" EXACT [GOC:TermGenie] +synonym: "glycerol catabolic process to glycerone phosphate" EXACT [] +synonym: "glycerol catabolism to glycerone phosphate" EXACT [GOC:TermGenie] +synonym: "glycerol degradation to glycerone phosphate" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902863 +name: regulation of embryonic camera-type eye development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "regulation of embryonic eye development" EXACT [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0031076 ! embryonic camera-type eye development + +[Term] +id: GO:1902864 +name: negative regulation of embryonic camera-type eye development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "down regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "down regulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "down-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "down-regulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "downregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "downregulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "inhibition of embryonic camera-type eye development" NARROW [GOC:TermGenie] +synonym: "inhibition of embryonic eye development" NARROW [GOC:TermGenie] +synonym: "negative regulation of embryonic eye development" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1902863 ! regulation of embryonic camera-type eye development +relationship: negatively_regulates GO:0031076 ! embryonic camera-type eye development + +[Term] +id: GO:1902865 +name: positive regulation of embryonic camera-type eye development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "activation of embryonic camera-type eye development" NARROW [GOC:TermGenie] +synonym: "activation of embryonic eye development" NARROW [GOC:TermGenie] +synonym: "positive regulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "up regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "up regulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "up-regulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "up-regulation of embryonic eye development" EXACT [GOC:TermGenie] +synonym: "upregulation of embryonic camera-type eye development" EXACT [GOC:TermGenie] +synonym: "upregulation of embryonic eye development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1902863 ! regulation of embryonic camera-type eye development +relationship: positively_regulates GO:0031076 ! embryonic camera-type eye development + +[Term] +id: GO:1902866 +name: regulation of retina development in camera-type eye +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "regulation of retinal development" RELATED [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:1902867 +name: negative regulation of retina development in camera-type eye +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "down regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "down regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "down regulation of retinal development" RELATED [GOC:TermGenie] +synonym: "down-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "down-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "down-regulation of retinal development" RELATED [GOC:TermGenie] +synonym: "downregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "downregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "downregulation of retinal development" RELATED [GOC:TermGenie] +synonym: "inhibition of retina development in camera-style eye" NARROW [GOC:TermGenie] +synonym: "inhibition of retina development in camera-type eye" NARROW [GOC:TermGenie] +synonym: "inhibition of retinal development" RELATED [GOC:TermGenie] +synonym: "negative regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "negative regulation of retinal development" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902866 ! regulation of retina development in camera-type eye +relationship: negatively_regulates GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:1902868 +name: positive regulation of retina development in camera-type eye +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "activation of retina development in camera-style eye" NARROW [GOC:TermGenie] +synonym: "activation of retina development in camera-type eye" NARROW [GOC:TermGenie] +synonym: "activation of retinal development" RELATED [GOC:TermGenie] +synonym: "positive regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "positive regulation of retinal development" RELATED [GOC:TermGenie] +synonym: "up regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "up regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "up regulation of retinal development" RELATED [GOC:TermGenie] +synonym: "up-regulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "up-regulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinal development" RELATED [GOC:TermGenie] +synonym: "upregulation of retina development in camera-style eye" EXACT [GOC:TermGenie] +synonym: "upregulation of retina development in camera-type eye" EXACT [GOC:TermGenie] +synonym: "upregulation of retinal development" RELATED [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902866 ! regulation of retina development in camera-type eye +relationship: positively_regulates GO:0060041 ! retina development in camera-type eye + +[Term] +id: GO:1902869 +name: regulation of amacrine cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0035881 ! amacrine cell differentiation + +[Term] +id: GO:1902870 +name: negative regulation of amacrine cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "down regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of amacrine cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of amacrine neuron differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:1902869 ! regulation of amacrine cell differentiation +relationship: negatively_regulates GO:0035881 ! amacrine cell differentiation + +[Term] +id: GO:1902871 +name: positive regulation of amacrine cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "activation of amacrine cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of amacrine neuron differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of amacrine cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of amacrine neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:1902869 ! regulation of amacrine cell differentiation +relationship: positively_regulates GO:0035881 ! amacrine cell differentiation + +[Term] +id: GO:1902872 +name: regulation of horizontal cell localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0035852 ! horizontal cell localization + +[Term] +id: GO:1902873 +name: negative regulation of horizontal cell localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "down regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "down regulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "down regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "down regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "downregulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "downregulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "downregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "inhibition of horizontal cell localisation" NARROW [GOC:TermGenie] +synonym: "inhibition of horizontal cell localization" NARROW [GOC:TermGenie] +synonym: "inhibition of horizontal cell positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie] +synonym: "inhibition of retinal horizontal cell positioning" NARROW [GOC:TermGenie] +synonym: "negative regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1902872 ! regulation of horizontal cell localization +relationship: negatively_regulates GO:0035852 ! horizontal cell localization + +[Term] +id: GO:1902874 +name: positive regulation of horizontal cell localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of horizontal cell localization." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "activation of horizontal cell localisation" NARROW [GOC:TermGenie] +synonym: "activation of horizontal cell localization" NARROW [GOC:TermGenie] +synonym: "activation of horizontal cell positioning" NARROW [GOC:TermGenie] +synonym: "activation of laminar positioning of retinal horizontal cell" NARROW [GOC:TermGenie] +synonym: "activation of retinal horizontal cell positioning" NARROW [GOC:TermGenie] +synonym: "positive regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "up regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "up regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of horizontal cell localisation" EXACT [GOC:TermGenie] +synonym: "upregulation of horizontal cell localization" EXACT [GOC:TermGenie] +synonym: "upregulation of horizontal cell positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of laminar positioning of retinal horizontal cell" EXACT [GOC:TermGenie] +synonym: "upregulation of retinal horizontal cell positioning" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1902872 ! regulation of horizontal cell localization +relationship: positively_regulates GO:0035852 ! horizontal cell localization + +[Term] +id: GO:1902875 +name: regulation of embryonic pattern specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "regulation of embryonic pattern biosynthesis" BROAD [GOC:TermGenie] +synonym: "regulation of embryonic pattern formation" BROAD [GOC:TermGenie] +synonym: "regulation of ventral/lateral system" RELATED [GOC:TermGenie] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009880 ! embryonic pattern specification + +[Term] +id: GO:1902876 +name: negative regulation of embryonic pattern specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "down regulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "down regulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "down-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "downregulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "downregulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "inhibition of embryonic pattern specification" NARROW [GOC:TermGenie] +synonym: "inhibition of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "negative regulation of ventral/lateral system" RELATED [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1902875 ! regulation of embryonic pattern specification +relationship: negatively_regulates GO:0009880 ! embryonic pattern specification + +[Term] +id: GO:1902877 +name: positive regulation of embryonic pattern specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of embryonic pattern specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16872597] +synonym: "activation of embryonic pattern specification" NARROW [GOC:TermGenie] +synonym: "activation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "positive regulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "up regulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "up regulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "up-regulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of ventral/lateral system" RELATED [GOC:TermGenie] +synonym: "upregulation of embryonic pattern specification" EXACT [GOC:TermGenie] +synonym: "upregulation of ventral/lateral system" RELATED [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1902875 ! regulation of embryonic pattern specification +relationship: positively_regulates GO:0009880 ! embryonic pattern specification + +[Term] +id: GO:1902878 +name: obsolete regulation of BMP signaling pathway involved in spinal cord association neuron specification +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902879 +name: obsolete negative regulation of BMP signaling pathway involved in spinal cord association neuron specification +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "down regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "downregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "downregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "downregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "downregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "inhibition of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "inhibition of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "inhibition of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "inhibition of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "negative regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "negative regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "negative regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902880 +name: obsolete positive regulation of BMP signaling pathway involved in spinal cord association neuron specification +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in spinal cord association neuron specification." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:21730158] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "activation of BMP signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "activation of BMP signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "activation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "activation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" NARROW [GOC:TermGenie] +synonym: "positive regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "positive regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "positive regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "upregulation of BMP signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "upregulation of bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +synonym: "upregulation of bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902882 +name: regulation of response to oxidative stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0006979 ! response to oxidative stress + +[Term] +id: GO:1902883 +name: negative regulation of response to oxidative stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] +synonym: "down regulation of response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "inhibition of response to oxidative stress" NARROW [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1902882 ! regulation of response to oxidative stress +relationship: negatively_regulates GO:0006979 ! response to oxidative stress + +[Term] +id: GO:1902884 +name: positive regulation of response to oxidative stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to oxidative stress." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16899554] +synonym: "activation of response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "up regulation of response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1902882 ! regulation of response to oxidative stress +relationship: positively_regulates GO:0006979 ! response to oxidative stress + +[Term] +id: GO:1902885 +name: obsolete regulation of proteasome-activating ATPase activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902886 +name: obsolete negative regulation of proteasome-activating ATPase activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "down regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "down regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "downregulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "downregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of proteasomal ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "inhibition of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "inhibition of proteasome-activating ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902887 +name: obsolete positive regulation of proteasome-activating ATPase activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of proteasome-activating ATPase activity." [GO_REF:0000059, GOC:di, GOC:TermGenie, PMID:23995839] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of ATPase involved in positive regulation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of proteasomal ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "activation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "activation of proteasome-activating ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "up regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "up regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "up regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATPase involved in positive regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasomal ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of proteasome channel gating activity" NARROW [GOC:TermGenie] +synonym: "upregulation of proteasome channel opening activity" NARROW [GOC:TermGenie] +synonym: "upregulation of proteasome-activating ATPase activity" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1902888 +name: protein localization to astral microtubule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an astral microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030] +synonym: "protein localisation in astral microtubule" EXACT [GOC:TermGenie] +synonym: "protein localisation to astral microtubule" EXACT [GOC:TermGenie] +synonym: "protein localization in astral microtubule" EXACT [GOC:TermGenie] +is_a: GO:1902889 ! protein localization to spindle microtubule +is_a: GO:1905755 ! protein localization to cytoplasmic microtubule + +[Term] +id: GO:1902889 +name: protein localization to spindle microtubule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a spindle microtubule." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:16054030] +synonym: "protein localisation in spindle microtubule" EXACT [GOC:TermGenie] +synonym: "protein localisation to spindle microtubule" EXACT [GOC:TermGenie] +synonym: "protein localization in spindle microtubule" EXACT [GOC:TermGenie] +is_a: GO:0035372 ! protein localization to microtubule + +[Term] +id: GO:1902890 +name: regulation of root hair elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0048767 ! root hair elongation + +[Term] +id: GO:1902891 +name: negative regulation of root hair elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] +synonym: "down regulation of root hair elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of root hair elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of root hair elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of root hair elongation" NARROW [GOC:TermGenie] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1902890 ! regulation of root hair elongation +is_a: GO:1903430 ! negative regulation of cell maturation +relationship: negatively_regulates GO:0048767 ! root hair elongation + +[Term] +id: GO:1902892 +name: positive regulation of root hair elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of root hair elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22329353] +synonym: "activation of root hair elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of root hair elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of root hair elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of root hair elongation" EXACT [GOC:TermGenie] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1902890 ! regulation of root hair elongation +is_a: GO:1903431 ! positive regulation of cell maturation +relationship: positively_regulates GO:0048767 ! root hair elongation + +[Term] +id: GO:1902893 +name: regulation of miRNA transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] +synonym: "regulation of microRNA gene transcription" EXACT [] +synonym: "regulation of miRNA gene transcription" EXACT [] +synonym: "regulation of pri-miRNA transcription by RNA polymerase II" EXACT [] +synonym: "regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] +synonym: "regulation of primary miRNA gene transcription" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0061614 ! miRNA transcription + +[Term] +id: GO:1902894 +name: negative regulation of miRNA transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] +synonym: "down regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of microRNA gene transcription" EXACT [] +synonym: "negative regulation of miRNA gene transcription" EXACT [] +synonym: "negative regulation of pri-miRNA transcription by RNA polymerase II" EXACT [] +synonym: "negative regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] +synonym: "negative regulation of primary miRNA gene transcription" EXACT [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:1902893 ! regulation of miRNA transcription +relationship: negatively_regulates GO:0061614 ! miRNA transcription + +[Term] +id: GO:1902895 +name: positive regulation of miRNA transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microRNA (miRNA) gene transcription." [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545] +synonym: "activation of pri-miRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of microRNA gene transcription" EXACT [] +synonym: "positive regulation of pri-miRNA gene transcription" EXACT [] +synonym: "positive regulation of pri-miRNA transcription by RNA polymerase II" EXACT [] +synonym: "positive regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [] +synonym: "positive regulation of primary miRNA gene transcription" EXACT [] +synonym: "up regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of pri-miRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:1902893 ! regulation of miRNA transcription +relationship: positively_regulates GO:0061614 ! miRNA transcription + +[Term] +id: GO:1902896 +name: terminal web assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a terminal web." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:21949650] +synonym: "terminal web formation" EXACT [GOC:TermGenie] +is_a: GO:0030866 ! cortical actin cytoskeleton organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:1902897 +name: regulation of postsynaptic density protein 95 clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:10570482] +synonym: "regulation of Dlg4 clustering" EXACT [GOC:TermGenie] +synonym: "regulation of post-synaptic density protein 95 clustering" EXACT [GOC:TermGenie] +synonym: "regulation of PSD-95 clustering" EXACT [GOC:TermGenie] +is_a: GO:1905475 ! regulation of protein localization to membrane +is_a: GO:1905874 ! regulation of postsynaptic density organization +relationship: regulates GO:0097119 ! postsynaptic density protein 95 clustering + +[Term] +id: GO:1902898 +name: fatty acid methyl ester metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218] +synonym: "FAME metabolic process" EXACT [] +synonym: "fatty acid methyl ester metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006629 ! lipid metabolic process + +[Term] +id: GO:1902899 +name: fatty acid methyl ester biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty acid methyl ester." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:16570218] +synonym: "FAME biosynthetic process" EXACT [] +synonym: "fatty acid methyl ester anabolism" EXACT [GOC:TermGenie] +synonym: "fatty acid methyl ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "fatty acid methyl ester formation" EXACT [GOC:TermGenie] +synonym: "fatty acid methyl ester synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:1902898 ! fatty acid methyl ester metabolic process + +[Term] +id: GO:1902900 +name: gut granule assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a gut granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, pmid:17202409] +synonym: "gut granule biogenesis" EXACT [pmid:17202409] +synonym: "gut granule formation" EXACT [GOC:TermGenie] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:1902901 +name: positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:17888400] +synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" NARROW [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:1990170 ! stress response to cadmium ion + +[Term] +id: GO:1902902 +name: negative regulation of autophagosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012] +synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] +synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie] +synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie] +synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie] +synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie] +synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie] +synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie] +synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] +synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:2000785 ! regulation of autophagosome assembly +relationship: negatively_regulates GO:0000045 ! autophagosome assembly + +[Term] +id: GO:1902903 +name: regulation of supramolecular fiber organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] +comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro +synonym: "regulation of fibril organisation" RELATED [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1902904 +name: negative regulation of supramolecular fiber organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] +comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro +synonym: "down regulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "down regulation of fibril organization" RELATED [GOC:TermGenie] +synonym: "down-regulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "down-regulation of fibril organization" RELATED [GOC:TermGenie] +synonym: "downregulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "downregulation of fibril organization" RELATED [GOC:TermGenie] +synonym: "inhibition of fibril organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of fibril organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of fibril organisation" RELATED [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1902905 +name: positive regulation of supramolecular fiber organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:23921388] +comment: HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro +synonym: "activation of fibril organisation" NARROW [GOC:TermGenie] +synonym: "activation of fibril organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "up regulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "up regulation of fibril organization" RELATED [GOC:TermGenie] +synonym: "up-regulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "up-regulation of fibril organization" RELATED [GOC:TermGenie] +synonym: "upregulation of fibril organisation" RELATED [GOC:TermGenie] +synonym: "upregulation of fibril organization" RELATED [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: positively_regulates GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1902906 +name: proteasome storage granule assembly +namespace: biological_process +alt_id: GO:1990237 +def: "The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178] +synonym: "proteasome storage granule formation" EXACT [GOC:TermGenie] +synonym: "PSG assembly" RELATED [GOC:TermGenie] +synonym: "PSG formation" RELATED [GOC:TermGenie] +synonym: "sequestration of proteasome core complex in proteasome storage granule" NARROW [] +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:1902907 +name: proteasome storage granule disassembly +namespace: biological_process +def: "The disaggregation of a proteasome storage granule into its constituent components." [GO_REF:0000079, GOC:di, GOC:TermGenie, PMID:23690178] +synonym: "PSG disassembly" RELATED [GOC:TermGenie] +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1902908 +name: regulation of melanosome transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] +is_a: GO:0051049 ! regulation of transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0032402 ! melanosome transport + +[Term] +id: GO:1902909 +name: negative regulation of melanosome transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] +synonym: "down regulation of melanosome transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of melanosome transport" EXACT [GOC:TermGenie] +synonym: "downregulation of melanosome transport" EXACT [GOC:TermGenie] +synonym: "inhibition of melanosome transport" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1902908 ! regulation of melanosome transport +relationship: negatively_regulates GO:0032402 ! melanosome transport + +[Term] +id: GO:1902910 +name: positive regulation of melanosome transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of melanosome transport." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23334344] +synonym: "activation of melanosome transport" NARROW [GOC:TermGenie] +synonym: "up regulation of melanosome transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of melanosome transport" EXACT [GOC:TermGenie] +synonym: "upregulation of melanosome transport" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1902908 ! regulation of melanosome transport +relationship: positively_regulates GO:0032402 ! melanosome transport + +[Term] +id: GO:1902911 +name: protein kinase complex +namespace: cellular_component +def: "A protein complex which is capable of protein kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] +comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:1902912 +name: pyruvate kinase complex +namespace: cellular_component +def: "A protein complex which is capable of pyruvate kinase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918] +comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). +is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups + +[Term] +id: GO:1902913 +name: positive regulation of neuroepithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:16916506] +synonym: "activation of neuroepithelial cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of neuroepithelial cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +relationship: positively_regulates GO:0060563 ! neuroepithelial cell differentiation + +[Term] +id: GO:1902914 +name: regulation of protein polyubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] +synonym: "regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031396 ! regulation of protein ubiquitination +relationship: regulates GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:1902915 +name: negative regulation of protein polyubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] +synonym: "down regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "down regulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "downregulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "downregulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "inhibition of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "inhibition of protein polyubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of protein polyubiquitinylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein polyubiquitylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:1902914 ! regulation of protein polyubiquitination +relationship: negatively_regulates GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:1902916 +name: positive regulation of protein polyubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein polyubiquitination." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23645667] +synonym: "activation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "activation of protein polyubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein polyubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of protein polyubiquitylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "up regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "up regulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +synonym: "upregulation of polyubiquitin" RELATED [GOC:TermGenie] +synonym: "upregulation of protein polyubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polyubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polyubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031398 ! positive regulation of protein ubiquitination +is_a: GO:1902914 ! regulation of protein polyubiquitination +relationship: positively_regulates GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:1902917 +name: positive regulation of mating projection assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mating projection assembly." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:12455985] +synonym: "activation of mating projection assembly" NARROW [GOC:TermGenie] +synonym: "activation of mating projection biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of mating projection biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of mating projection assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of mating projection biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of mating projection assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of mating projection biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of mating projection assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of mating projection biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0031383 ! regulation of mating projection assembly +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: part_of GO:0031139 ! positive regulation of conjugation with cellular fusion +relationship: positively_regulates GO:0031382 ! mating projection formation + +[Term] +id: GO:1902918 +name: poly(5-hydroxyvalerate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(5-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] +is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process + +[Term] +id: GO:1902919 +name: poly(5-hydroxyvalerate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(5-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(5-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] +synonym: "poly(5-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(5-hydroxyvalerate) formation" EXACT [GOC:TermGenie] +synonym: "poly(5-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] +is_a: GO:1902918 ! poly(5-hydroxyvalerate) metabolic process +is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process + +[Term] +id: GO:1902920 +name: poly(hydroxyvalerate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] +is_a: GO:1901440 ! poly(hydroxyalkanoate) metabolic process + +[Term] +id: GO:1902921 +name: poly(hydroxyvalerate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyvalerate) formation" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] +is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process +is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process + +[Term] +id: GO:1902922 +name: poly(3-hydroxyvalerate) metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(3-hydroxyvalerate) metabolism" EXACT [GOC:TermGenie] +is_a: GO:1902920 ! poly(hydroxyvalerate) metabolic process + +[Term] +id: GO:1902923 +name: poly(3-hydroxyvalerate) biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyvalerate)." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21705209] +synonym: "poly(3-hydroxyvalerate) anabolism" EXACT [GOC:TermGenie] +synonym: "poly(3-hydroxyvalerate) biosynthesis" EXACT [GOC:TermGenie] +synonym: "poly(3-hydroxyvalerate) formation" EXACT [GOC:TermGenie] +synonym: "poly(3-hydroxyvalerate) synthesis" EXACT [GOC:TermGenie] +is_a: GO:1902921 ! poly(hydroxyvalerate) biosynthetic process +is_a: GO:1902922 ! poly(3-hydroxyvalerate) metabolic process + +[Term] +id: GO:1902924 +name: poly(hydroxyalkanoate) biosynthetic process from glucose +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from glucose." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:24425304] +synonym: "poly(hydroxyalkanoate) anabolism from glucose" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) biosynthesis from glucose" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) formation from glucose" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) synthesis from glucose" EXACT [GOC:TermGenie] +is_a: GO:0006006 ! glucose metabolic process +is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process + +[Term] +id: GO:1902925 +name: poly(hydroxyalkanoate) biosynthetic process from fatty acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate) from fatty acid." [GO_REF:0000092, GOC:mengo_curators, GOC:TermGenie, PMID:21129764] +synonym: "poly(hydroxyalkanoate) anabolism from fatty acid" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) biosynthesis from fatty acid" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) formation from fatty acid" EXACT [GOC:TermGenie] +synonym: "poly(hydroxyalkanoate) synthesis from fatty acid" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:1901441 ! poly(hydroxyalkanoate) biosynthetic process + +[Term] +id: GO:1902926 +name: inulin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] +comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. +synonym: "inulin metabolism" EXACT [GOC:TermGenie] +is_a: GO:0010145 ! fructan metabolic process + +[Term] +id: GO:1902927 +name: inulin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] +comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. +synonym: "inulin breakdown" EXACT [GOC:TermGenie] +synonym: "inulin catabolism" EXACT [GOC:TermGenie] +synonym: "inulin degradation" EXACT [GOC:TermGenie] +is_a: GO:0010147 ! fructan catabolic process +is_a: GO:1902926 ! inulin metabolic process + +[Term] +id: GO:1902928 +name: inulin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of inulin." [GO_REF:0000068, GOC:TermGenie, PMID:23104410] +comment: SUC2 in S. cerevisiae strain JZ1C in PMID:23104410. +synonym: "inulin anabolism" EXACT [GOC:TermGenie] +synonym: "inulin biosynthesis" EXACT [GOC:TermGenie] +synonym: "inulin formation" EXACT [GOC:TermGenie] +synonym: "inulin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010146 ! fructan biosynthetic process +is_a: GO:1902926 ! inulin metabolic process + +[Term] +id: GO:1902929 +name: plasma membrane of growing cell tip +namespace: cellular_component +def: "Any plasma membrane part that is part of a growing cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:17085965] +synonym: "growing cell tip plasma membrane part" EXACT [GOC:TermGenie] +synonym: "plasma membrane part of growing cell end" EXACT [GOC:TermGenie] +synonym: "plasma membrane part of growing cell tip" EXACT [GOC:TermGenie] +is_a: GO:0031520 ! plasma membrane of cell tip +relationship: part_of GO:0035838 ! growing cell tip + +[Term] +id: GO:1902930 +name: regulation of alcohol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] +synonym: "regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of solventogenesis" BROAD [] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:1902931 +name: negative regulation of alcohol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] +synonym: "down regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "down regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "downregulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of alcohol anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of alcohol biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of alcohol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of alcohol formation" NARROW [GOC:TermGenie] +synonym: "inhibition of alcohol synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of solventogenesis" BROAD [] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: negatively_regulates GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:1902932 +name: positive regulation of alcohol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alcohol biosynthetic process." [GO_REF:0000058, GOC:mengo_curators, GOC:TermGenie, PMID:23332010] +synonym: "activation of alcohol anabolism" NARROW [GOC:TermGenie] +synonym: "activation of alcohol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of alcohol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of alcohol formation" NARROW [GOC:TermGenie] +synonym: "activation of alcohol synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of solventogenesis" BROAD [] +synonym: "up regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of alcohol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of alcohol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of alcohol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of alcohol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: positively_regulates GO:0046165 ! alcohol biosynthetic process + +[Term] +id: GO:1902933 +name: isopentenol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564] +synonym: "isopentenol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process + +[Term] +id: GO:1902934 +name: isopentenol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of isopentenol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:17693564] +synonym: "isopentenol anabolism" EXACT [GOC:TermGenie] +synonym: "isopentenol biosynthesis" EXACT [GOC:TermGenie] +synonym: "isopentenol formation" EXACT [GOC:TermGenie] +synonym: "isopentenol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:1902933 ! isopentenol metabolic process + +[Term] +id: GO:1902935 +name: protein localization to septin ring +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a septin ring." [GO_REF:0000087, GOC:TermGenie, PMID:16325501] +synonym: "protein localisation in septin ring" EXACT [GOC:TermGenie] +synonym: "protein localisation to septin ring" EXACT [GOC:TermGenie] +synonym: "protein localization in septin ring" EXACT [GOC:TermGenie] +is_a: GO:0044380 ! protein localization to cytoskeleton +is_a: GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:1902936 +name: phosphatidylinositol bisphosphate binding +namespace: molecular_function +def: "Binding to phosphatidylinositol bisphosphate." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034] +comment: An example of this is KCNJ2 in human (P63252) in PMID:18690034 (inferred from direct assay) +is_a: GO:1901981 ! phosphatidylinositol phosphate binding + +[Term] +id: GO:1902937 +name: inward rectifier potassium channel complex +namespace: cellular_component +def: "A protein complex which is capable of inward rectifier potassium channel activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16834334] +comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). +is_a: GO:0008076 ! voltage-gated potassium channel complex + +[Term] +id: GO:1902938 +name: regulation of intracellular calcium activated chloride channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] +is_a: GO:0010359 ! regulation of anion channel activity +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:2001225 ! regulation of chloride transport + +[Term] +id: GO:1902939 +name: negative regulation of intracellular calcium activated chloride channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] +synonym: "down regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie] +is_a: GO:0010360 ! negative regulation of anion channel activity +is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity +is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport +is_a: GO:2001226 ! negative regulation of chloride transport + +[Term] +id: GO:1902940 +name: positive regulation of intracellular calcium activated chloride channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22946059] +synonym: "activation of intracellular calcium activated chloride channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular calcium activated chloride channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901529 ! positive regulation of anion channel activity +is_a: GO:1902938 ! regulation of intracellular calcium activated chloride channel activity +is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport + +[Term] +id: GO:1902941 +name: regulation of voltage-gated chloride channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] +synonym: "regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +is_a: GO:0010359 ! regulation of anion channel activity +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:2001225 ! regulation of chloride transport + +[Term] +id: GO:1902942 +name: negative regulation of voltage-gated chloride channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] +synonym: "down regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage gated chloride channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated chloride channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +is_a: GO:0010360 ! negative regulation of anion channel activity +is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity +is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport +is_a: GO:2001226 ! negative regulation of chloride transport + +[Term] +id: GO:1902943 +name: positive regulation of voltage-gated chloride channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22006324] +synonym: "activation of voltage gated chloride channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-dependent chloride channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated chloride channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage gated chloride channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-dependent chloride channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated chloride channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901529 ! positive regulation of anion channel activity +is_a: GO:1902941 ! regulation of voltage-gated chloride channel activity +is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport + +[Term] +id: GO:1902944 +name: aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +namespace: molecular_function +def: "Any aspartic-type endopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:10206644, PMID:24577224] +synonym: "aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +is_a: GO:0004190 ! aspartic-type endopeptidase activity + +[Term] +id: GO:1902945 +name: metalloendopeptidase activity involved in amyloid precursor protein catabolic process +namespace: molecular_function +def: "Any metalloendopeptidase activity that is involved in amyloid precursor protein catabolic process." [GO_REF:0000061, GOC:sjp, GOC:TermGenie, PMID:14598310, PMID:17855360] +synonym: "metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] +xref: Reactome:R-HSA-9010034 "ADAM10:Zn2+:TSPANs cleaves APP(18-770)" +is_a: GO:0004222 ! metalloendopeptidase activity + +[Term] +id: GO:1902946 +name: protein localization to early endosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an early endosome." [GO_REF:0000087, GOC:sjp, GOC:TermGenie, PMID:22621900] +synonym: "protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "protein localization in early endosome" EXACT [GOC:TermGenie] +is_a: GO:0036010 ! protein localization to endosome + +[Term] +id: GO:1902947 +name: regulation of tau-protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] +synonym: "regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:tau-protein O-phosphotransferase activity" BROAD [GOC:TermGenie] +synonym: "regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "regulation of GSK" RELATED [GOC:TermGenie] +synonym: "regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of STK31" RELATED [GOC:TermGenie] +synonym: "regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of TPK" RELATED [GOC:TermGenie] +synonym: "regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "regulation of TTK" RELATED [GOC:TermGenie] +is_a: GO:0045859 ! regulation of protein kinase activity + +[Term] +id: GO:1902948 +name: negative regulation of tau-protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] +synonym: "down regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "down regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "down regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "down regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "down regulation of GSK" RELATED [GOC:TermGenie] +synonym: "down regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of STK31" RELATED [GOC:TermGenie] +synonym: "down regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "down regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "down regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of TPK" RELATED [GOC:TermGenie] +synonym: "down regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "down regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "down regulation of TTK" RELATED [GOC:TermGenie] +synonym: "down-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "down-regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "down-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of GSK" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of STK31" RELATED [GOC:TermGenie] +synonym: "down-regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of TPK" RELATED [GOC:TermGenie] +synonym: "down-regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "down-regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "down-regulation of TTK" RELATED [GOC:TermGenie] +synonym: "downregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "downregulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "downregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "downregulation of GSK" RELATED [GOC:TermGenie] +synonym: "downregulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of STK31" RELATED [GOC:TermGenie] +synonym: "downregulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "downregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "downregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of TPK" RELATED [GOC:TermGenie] +synonym: "downregulation of TPK I" RELATED [GOC:TermGenie] +synonym: "downregulation of TPK II" RELATED [GOC:TermGenie] +synonym: "downregulation of TTK" RELATED [GOC:TermGenie] +synonym: "inhibition of [Tau protein] kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "inhibition of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "inhibition of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GSK" RELATED [GOC:TermGenie] +synonym: "inhibition of protein tau kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of STK31" RELATED [GOC:TermGenie] +synonym: "inhibition of tau kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tau protein kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tau-protein kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of TPK" RELATED [GOC:TermGenie] +synonym: "inhibition of TPK I" RELATED [GOC:TermGenie] +synonym: "inhibition of TPK II" RELATED [GOC:TermGenie] +synonym: "inhibition of TTK" RELATED [GOC:TermGenie] +synonym: "negative regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "negative regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "negative regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of GSK" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of STK31" RELATED [GOC:TermGenie] +synonym: "negative regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of TPK" RELATED [GOC:TermGenie] +synonym: "negative regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "negative regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "negative regulation of TTK" RELATED [GOC:TermGenie] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:1902947 ! regulation of tau-protein kinase activity + +[Term] +id: GO:1902949 +name: positive regulation of tau-protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780] +synonym: "activation of [Tau protein] kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "activation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "activation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "activation of glycogen synthase kinase-3beta activity" NARROW [GOC:TermGenie] +synonym: "activation of GSK" RELATED [GOC:TermGenie] +synonym: "activation of protein tau kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of STK31" RELATED [GOC:TermGenie] +synonym: "activation of tau kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of tau protein kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of tau-protein kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "activation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "activation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of TPK" RELATED [GOC:TermGenie] +synonym: "activation of TPK I" RELATED [GOC:TermGenie] +synonym: "activation of TPK II" RELATED [GOC:TermGenie] +synonym: "activation of TTK" RELATED [GOC:TermGenie] +synonym: "positive regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "positive regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "positive regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of GSK" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of STK31" RELATED [GOC:TermGenie] +synonym: "positive regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of TPK" RELATED [GOC:TermGenie] +synonym: "positive regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "positive regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "positive regulation of TTK" RELATED [GOC:TermGenie] +synonym: "up regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "up regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "up regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "up regulation of GSK" RELATED [GOC:TermGenie] +synonym: "up regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of STK31" RELATED [GOC:TermGenie] +synonym: "up regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "up regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "up regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of TPK" RELATED [GOC:TermGenie] +synonym: "up regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "up regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "up regulation of TTK" RELATED [GOC:TermGenie] +synonym: "up-regulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "up-regulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "up-regulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of GSK" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of STK31" RELATED [GOC:TermGenie] +synonym: "up-regulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of TPK" RELATED [GOC:TermGenie] +synonym: "up-regulation of TPK I" RELATED [GOC:TermGenie] +synonym: "up-regulation of TPK II" RELATED [GOC:TermGenie] +synonym: "up-regulation of TTK" RELATED [GOC:TermGenie] +synonym: "upregulation of [Tau protein] kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of brain protein kinase PK40erk activity" NARROW [GOC:TermGenie] +synonym: "upregulation of cdk5/p20" RELATED [GOC:TermGenie] +synonym: "upregulation of CDK5/p23" RELATED [GOC:TermGenie] +synonym: "upregulation of glycogen synthase kinase-3beta activity" EXACT [GOC:TermGenie] +synonym: "upregulation of GSK" RELATED [GOC:TermGenie] +synonym: "upregulation of protein tau kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of STK31" RELATED [GOC:TermGenie] +synonym: "upregulation of tau kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tau protein kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tau-protein kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tau-protein kinase I activity" NARROW [GOC:TermGenie] +synonym: "upregulation of tau-protein kinase II activity" NARROW [GOC:TermGenie] +synonym: "upregulation of tau-tubulin kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of TPK" RELATED [GOC:TermGenie] +synonym: "upregulation of TPK I" RELATED [GOC:TermGenie] +synonym: "upregulation of TPK II" RELATED [GOC:TermGenie] +synonym: "upregulation of TTK" RELATED [GOC:TermGenie] +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:1902947 ! regulation of tau-protein kinase activity + +[Term] +id: GO:1902950 +name: regulation of dendritic spine maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] +is_a: GO:0099175 ! regulation of postsynapse organization +is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization +relationship: regulates GO:0097062 ! dendritic spine maintenance + +[Term] +id: GO:1902951 +name: negative regulation of dendritic spine maintenance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] +synonym: "down regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +synonym: "inhibition of dendritic spine maintenance" NARROW [GOC:TermGenie] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:1902950 ! regulation of dendritic spine maintenance +relationship: negatively_regulates GO:0097062 ! dendritic spine maintenance + +[Term] +id: GO:1902952 +name: positive regulation of dendritic spine maintenance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendritic spine maintenance." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24328732] +synonym: "activation of dendritic spine maintenance" NARROW [GOC:TermGenie] +synonym: "up regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +synonym: "up-regulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +synonym: "upregulation of dendritic spine maintenance" EXACT [GOC:TermGenie] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:1902950 ! regulation of dendritic spine maintenance +relationship: positively_regulates GO:0097062 ! dendritic spine maintenance + +[Term] +id: GO:1902953 +name: positive regulation of ER to Golgi vesicle-mediated transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:17855360] +synonym: "activation of endoplasmic reticulum to Golgi transport" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] +synonym: "activation of ER to Golgi transport" NARROW [GOC:TermGenie] +synonym: "activation of ER to Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] +synonym: "activation of rough endoplasmic reticulum to cis-Golgi transport" NARROW [GOC:TermGenie] +synonym: "activation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] +synonym: "activation of rough ER to cis-Golgi transport" NARROW [GOC:TermGenie] +synonym: "activation of rough ER to cis-Golgi vesicle-mediated transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER to Golgi transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up regulation of ER to Golgi transport" EXACT [GOC:TermGenie] +synonym: "up regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "up regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "up regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER to Golgi transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum to Golgi transport" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "upregulation of ER to Golgi transport" EXACT [GOC:TermGenie] +synonym: "upregulation of ER to Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "upregulation of rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +synonym: "upregulation of rough ER to cis-Golgi transport" EXACT [GOC:TermGenie] +synonym: "upregulation of rough ER to cis-Golgi vesicle-mediated transport" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0060628 ! regulation of ER to Golgi vesicle-mediated transport +relationship: positively_regulates GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:1902954 +name: regulation of early endosome to recycling endosome transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: regulates GO:0061502 ! early endosome to recycling endosome transport + +[Term] +id: GO:1902955 +name: positive regulation of early endosome to recycling endosome transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of early endosome to recycling endosome transport." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] +synonym: "activation of early endosome to recycling endosome transport" NARROW [GOC:TermGenie] +synonym: "up regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] +synonym: "upregulation of early endosome to recycling endosome transport" EXACT [GOC:TermGenie] +is_a: GO:1902954 ! regulation of early endosome to recycling endosome transport +is_a: GO:1903651 ! positive regulation of cytoplasmic transport +relationship: positively_regulates GO:0061502 ! early endosome to recycling endosome transport + +[Term] +id: GO:1902956 +name: regulation of mitochondrial electron transport, NADH to ubiquinone +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] +synonym: "regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +is_a: GO:1903715 ! regulation of aerobic respiration +relationship: regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone + +[Term] +id: GO:1902957 +name: negative regulation of mitochondrial electron transport, NADH to ubiquinone +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] +synonym: "down regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "down regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "down-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "down-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "downregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "downregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "inhibition of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "inhibition of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie] +synonym: "negative regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "negative regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone +is_a: GO:1905447 ! negative regulation of mitochondrial ATP synthesis coupled electron transport +relationship: negatively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone + +[Term] +id: GO:1902958 +name: positive regulation of mitochondrial electron transport, NADH to ubiquinone +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23530063] +synonym: "activation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "activation of mitochondrial electron transport, NADH to ubiquinone" NARROW [GOC:TermGenie] +synonym: "activation of oxidative phosphorylation, NADH to ubiquinone" NARROW [GOC:TermGenie] +synonym: "positive regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "positive regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "up regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "up regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "up-regulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "up-regulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "upregulation of complex I (NADH to ubiquinone)" RELATED [GOC:TermGenie] +synonym: "upregulation of mitochondrial electron transport, NADH to ubiquinone" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidative phosphorylation, NADH to ubiquinone" EXACT [GOC:TermGenie] +is_a: GO:1901857 ! positive regulation of cellular respiration +is_a: GO:1902956 ! regulation of mitochondrial electron transport, NADH to ubiquinone +relationship: positively_regulates GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone + +[Term] +id: GO:1902959 +name: regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] +synonym: "regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0052548 ! regulation of endopeptidase activity +is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process +is_a: GO:1905245 ! regulation of aspartic-type peptidase activity + +[Term] +id: GO:1902960 +name: negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] +synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0010951 ! negative regulation of endopeptidase activity +is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process +is_a: GO:1905246 ! negative regulation of aspartic-type peptidase activity + +[Term] +id: GO:1902961 +name: positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:24577224] +synonym: "activation of aspartate protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartate protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartate protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of aspartate protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartate protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartic-type endopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of aspartyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of carboxyl protease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type endopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of carboxyl protease activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0010950 ! positive regulation of endopeptidase activity +is_a: GO:1902959 ! regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process +is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process +is_a: GO:1905247 ! positive regulation of aspartic-type peptidase activity + +[Term] +id: GO:1902962 +name: regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] +synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process +is_a: GO:1904683 ! regulation of metalloendopeptidase activity + +[Term] +id: GO:1902963 +name: negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] +synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process +is_a: GO:1902992 ! negative regulation of amyloid precursor protein catabolic process +is_a: GO:1904684 ! negative regulation of metalloendopeptidase activity + +[Term] +id: GO:1902964 +name: positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." [GO_REF:0000059, GOC:sjp, GOC:TermGenie, PMID:18362153] +synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of metalloendopeptidase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of metalloendopeptidase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendopeptidase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity involved in APP catabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity involved in APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity involved in APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:1902962 ! regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process +is_a: GO:1902993 ! positive regulation of amyloid precursor protein catabolic process +is_a: GO:1904685 ! positive regulation of metalloendopeptidase activity + +[Term] +id: GO:1902965 +name: regulation of protein localization to early endosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] +synonym: "regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in early endosome" EXACT [GOC:TermGenie] +is_a: GO:1905666 ! regulation of protein localization to endosome +relationship: regulates GO:1902946 ! protein localization to early endosome + +[Term] +id: GO:1902966 +name: positive regulation of protein localization to early endosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to early endosome." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:22621900] +synonym: "activation of protein localisation in early endosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to early endosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in early endosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to early endosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in early endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in early endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to early endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in early endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to early endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in early endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to early endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in early endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to early endosome" EXACT [GOC:TermGenie] +is_a: GO:1902965 ! regulation of protein localization to early endosome +is_a: GO:1905668 ! positive regulation of protein localization to endosome +relationship: positively_regulates GO:1902946 ! protein localization to early endosome + +[Term] +id: GO:1902967 +name: protein localization to mitotic spindle midzone +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone." [GO_REF:0000087, GOC:TermGenie, PMID:16824200] +synonym: "protein localisation in mitotic spindle midzone" EXACT [GOC:TermGenie] +synonym: "protein localisation to mitotic spindle midzone" EXACT [GOC:TermGenie] +synonym: "protein localization in mitotic spindle midzone" EXACT [GOC:TermGenie] +is_a: GO:1902480 ! protein localization to mitotic spindle + +[Term] +id: GO:1902969 +name: mitotic DNA replication +namespace: biological_process +def: "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "mitotic cell cycle DNA replication" EXACT [] +synonym: "mitotic nuclear cell cycle DNA replication" EXACT [] +synonym: "nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [] +is_a: GO:0033260 ! nuclear DNA replication +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:1902970 +name: premeiotic DNA replication DNA duplex unwinding +namespace: biological_process +def: "Any DNA duplex unwinding involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA duplex unwinding involved in meiotic cell cycle DNA replication" EXACT [] +synonym: "DNA duplex unwinding involved in meiotic DNA replication" EXACT [] +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902971 +name: mitotic DNA replication DNA duplex unwinding +namespace: biological_process +def: "Any DNA duplex unwinding involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA duplex unwinding involved in mitotic cell cycle DNA replication" EXACT [] +synonym: "DNA duplex unwinding involved in mitotic DNA replication" EXACT [] +is_a: GO:1902320 ! nuclear DNA replication DNA duplex unwinding +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902972 +name: premeiotic DNA replication DNA ligation +namespace: biological_process +def: "Any DNA ligation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA ligation involved in meiotic cell cycle DNA replication" RELATED [] +synonym: "DNA ligation involved in meiotic DNA replication" EXACT [] +is_a: GO:1902333 ! nuclear DNA replication DNA ligation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902973 +name: mitotic DNA replication DNA ligation +namespace: biological_process +def: "Any DNA ligation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA ligation involved in mitotic cell cycle DNA replication" EXACT [] +synonym: "DNA ligation involved in mitotic DNA replication" EXACT [] +is_a: GO:1902333 ! nuclear DNA replication DNA ligation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902974 +name: meiotic DNA replication initiation +namespace: biological_process +alt_id: GO:0072691 +def: "Any DNA replication initiation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:10888871] +synonym: "DNA replication initiation involved in meiotic cell cycle DNA replication" EXACT [] +synonym: "DNA replication initiation involved in meiotic DNA replication" EXACT [] +synonym: "initiation of meiotic DNA synthesis" RELATED [GOC:mah] +synonym: "initiation of premeiotic DNA replication" RELATED [] +synonym: "initiation of premeiotic DNA synthesis" RELATED [GOC:mah] +synonym: "premeiotic DNA replication initiation" RELATED [GOC:mah] +is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation +is_a: GO:1903046 ! meiotic cell cycle process + +[Term] +id: GO:1902975 +name: mitotic DNA replication initiation +namespace: biological_process +def: "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [] +is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902976 +name: premeiotic DNA replication preinitiation complex assembly +namespace: biological_process +def: "Any DNA replication preinitiation complex assembly that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication preinitiation complex formation involved in meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "pre-IC complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0071163 ! DNA replication preinitiation complex assembly +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902977 +name: mitotic DNA replication preinitiation complex assembly +namespace: biological_process +def: "Any DNA replication preinitiation complex assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication preinitiation complex formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "pre-IC complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0071163 ! DNA replication preinitiation complex assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902978 +name: premeiotic DNA replication termination +namespace: biological_process +def: "Any DNA replication termination involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication termination involved in meiotic cell cycle DNA replication" EXACT [] +synonym: "DNA replication termination involved in meiotic DNA replication" EXACT [] +is_a: GO:1902317 ! nuclear DNA replication termination +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902979 +name: mitotic DNA replication termination +namespace: biological_process +def: "Any DNA replication termination involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA replication termination involved in mitotic cell cycle DNA replication" EXACT [] +is_a: GO:1902317 ! nuclear DNA replication termination +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902980 +name: synthesis of RNA primer involved in premeiotic DNA replication +namespace: biological_process +def: "Any synthesis of RNA primer involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "synthesis of RNA primer involved in meiotic cell cycle DNA replication" EXACT [] +is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902981 +name: synthesis of RNA primer involved in mitotic DNA replication +namespace: biological_process +alt_id: GO:1903458 +def: "Any synthesis of RNA primer involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "synthesis of RNA primer involved in mitotic cell cycle DNA replication" EXACT [] +is_a: GO:1902318 ! synthesis of RNA primer involved in nuclear cell cycle DNA replication +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902982 +name: DNA strand elongation involved in premeiotic DNA replication +namespace: biological_process +def: "Any DNA strand elongation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA strand elongation involved in meiotic cell cycle DNA replication" EXACT [] +is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902983 +name: DNA strand elongation involved in mitotic DNA replication +namespace: biological_process +def: "Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "DNA strand elongation involved in mitotic cell cycle DNA replication" EXACT [] +is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902984 +name: pre-replicative complex assembly involved in premeiotic DNA replication +namespace: biological_process +def: "Any pre-replicative complex assembly involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "nuclear pre-replicative complex assembly involved in meiotic cell cycle" EXACT [GOC:TermGenie] +synonym: "pre-RC complex assembly involved in meiosis" BROAD [GOC:TermGenie] +synonym: "pre-replicative complex assembly involved in meiosis" BROAD [GOC:TermGenie] +synonym: "pre-replicative complex assembly involved in meiotic cell cycle DNA replication" EXACT [] +synonym: "pre-replicative complex formation involved in meiosis" BROAD [GOC:TermGenie] +is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0006279 ! premeiotic DNA replication + +[Term] +id: GO:1902985 +name: mitotic pre-replicative complex assembly +namespace: biological_process +def: "Any pre-replicative complex assembly involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] +synonym: "nuclear pre-replicative complex assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "pre-replicative complex assembly involved in mitotic cell cycle DNA replication" EXACT [] +is_a: GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1902986 +name: regulation of lysine biosynthetic process via aminoadipic acid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464] +synonym: "regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:1902987 +name: negative regulation of lysine biosynthetic process via aminoadipic acid +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via aminoadipic acid." [GO_REF:0000058, GOC:TermGenie, PMID:8590464] +synonym: "down regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine biosynthetic process via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "inhibition of lysine anabolism via aminoadipic acid" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine biosynthesis, aminoadipic acid pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine biosynthesis, aminoadipic pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine biosynthetic process via aminoadipic acid" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine biosynthetic process, aminoadipic acid pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine biosynthetic process, aminoadipic pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine formation via aminoadipic acid" NARROW [GOC:TermGenie] +synonym: "inhibition of lysine synthesis via aminoadipic acid" NARROW [GOC:TermGenie] +synonym: "negative regulation of lysine anabolism via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine biosynthesis, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine biosynthesis, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine biosynthetic process, aminoadipic acid pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine biosynthetic process, aminoadipic pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine formation via aminoadipic acid" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysine synthesis via aminoadipic acid" EXACT [GOC:TermGenie] +is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0019878 ! lysine biosynthetic process via aminoadipic acid + +[Term] +id: GO:1902988 +name: neurofibrillary tangle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle." [GO_REF:0000079, GOC:sjp, GOC:TermGenie, PMID:15897157, PMID:22986780, PMID:24154541] +comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). +synonym: "flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +is_a: GO:0070841 ! inclusion body assembly + +[Term] +id: GO:1902989 +name: meiotic telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any telomere maintenance via semi-conservative replication that is involved in meiotic cell cycle." [GO_REF:0000060, GOC:TermGenie] +synonym: "equal telomere replication involved in meiotic cell cycle" RELATED [GOC:TermGenie] +synonym: "telomeric fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie] +synonym: "telomeric replication fork progression involved in meiotic cell cycle" NARROW [GOC:TermGenie] +is_a: GO:0032201 ! telomere maintenance via semi-conservative replication +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle + +[Term] +id: GO:1902990 +name: mitotic telomere maintenance via semi-conservative replication +namespace: biological_process +def: "Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] +synonym: "equal telomere replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "telomeric fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "telomeric replication fork progression involved in mitotic cell cycle" NARROW [GOC:TermGenie] +is_a: GO:0032201 ! telomere maintenance via semi-conservative replication +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:1902991 +name: regulation of amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] +comment: An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay). +synonym: "regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0042987 ! amyloid precursor protein catabolic process + +[Term] +id: GO:1902992 +name: negative regulation of amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] +synonym: "down regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of APP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of APP catabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process +relationship: negatively_regulates GO:0042987 ! amyloid precursor protein catabolic process + +[Term] +id: GO:1902993 +name: positive regulation of amyloid precursor protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process." [GO_REF:0000058, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:24499793] +synonym: "activation of amyloid precursor protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of amyloid precursor protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of amyloid precursor protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of amyloid precursor protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of APP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of APP catabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of APP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of amyloid precursor protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of amyloid precursor protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of amyloid precursor protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of amyloid precursor protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of APP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of APP catabolism" EXACT [GOC:TermGenie] +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1902991 ! regulation of amyloid precursor protein catabolic process +relationship: positively_regulates GO:0042987 ! amyloid precursor protein catabolic process + +[Term] +id: GO:1902994 +name: regulation of phospholipid efflux +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] +synonym: "regulation of phospholipid export" EXACT [GOC:TermGenie] +is_a: GO:2001138 ! regulation of phospholipid transport +relationship: regulates GO:0033700 ! phospholipid efflux + +[Term] +id: GO:1902995 +name: positive regulation of phospholipid efflux +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] +synonym: "activation of phospholipid efflux" NARROW [GOC:TermGenie] +synonym: "activation of phospholipid export" NARROW [GOC:TermGenie] +synonym: "positive regulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipid export" EXACT [GOC:TermGenie] +is_a: GO:1902994 ! regulation of phospholipid efflux +is_a: GO:2001140 ! positive regulation of phospholipid transport +relationship: positively_regulates GO:0033700 ! phospholipid efflux + +[Term] +id: GO:1902996 +name: regulation of neurofibrillary tangle assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] +synonym: "regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +is_a: GO:0090083 ! regulation of inclusion body assembly +relationship: regulates GO:1902988 ! neurofibrillary tangle assembly + +[Term] +id: GO:1902997 +name: negative regulation of neurofibrillary tangle assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] +synonym: "down regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "down regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "down regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "downregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "downregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "inhibition of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "inhibition of neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "inhibition of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +is_a: GO:0090084 ! negative regulation of inclusion body assembly +is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly +relationship: negatively_regulates GO:1902988 ! neurofibrillary tangle assembly + +[Term] +id: GO:1902998 +name: positive regulation of neurofibrillary tangle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neurofibrillary tangle assembly." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:15897157] +synonym: "activation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "activation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "activation of neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "activation of neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "activation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "activation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "up regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "up regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "upregulation of flame-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of flame-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +synonym: "upregulation of neurofibrillary tangle assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of neurofibrillary tangle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of star-shaped neurofibrillary tangle assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of star-shaped neurofibrillary tangle formation" NARROW [GOC:TermGenie] +is_a: GO:0090261 ! positive regulation of inclusion body assembly +is_a: GO:1902996 ! regulation of neurofibrillary tangle assembly +relationship: positively_regulates GO:1902988 ! neurofibrillary tangle assembly + +[Term] +id: GO:1902999 +name: negative regulation of phospholipid efflux +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid efflux." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:12042316] +synonym: "down regulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "down regulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipid efflux" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipid export" EXACT [GOC:TermGenie] +synonym: "inhibition of phospholipid efflux" NARROW [GOC:TermGenie] +synonym: "inhibition of phospholipid export" NARROW [GOC:TermGenie] +synonym: "negative regulation of phospholipid export" EXACT [GOC:TermGenie] +is_a: GO:1902994 ! regulation of phospholipid efflux +is_a: GO:2001139 ! negative regulation of phospholipid transport +relationship: negatively_regulates GO:0033700 ! phospholipid efflux + +[Term] +id: GO:1903000 +name: regulation of lipid transport across blood-brain barrier +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] +synonym: "regulation of lipid transport across blood brain barrier" EXACT [] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0150200 ! regulation of transport across blood-brain barrier +relationship: regulates GO:1990379 ! lipid transport across blood-brain barrier + +[Term] +id: GO:1903001 +name: negative regulation of lipid transport across blood-brain barrier +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] +synonym: "down regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +synonym: "downregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +synonym: "inhibition of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of lipid transport across blood brain barrier" EXACT [] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0150202 ! negative regulation of transport across blood-brain barrier +is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier +relationship: negatively_regulates GO:1990379 ! lipid transport across blood-brain barrier + +[Term] +id: GO:1903002 +name: positive regulation of lipid transport across blood-brain barrier +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lipid transport across blood-brain barrier." [GO_REF:0000058, GOC:sjp, GOC:TermGenie, PMID:24345162] +synonym: "activation of lipid transport across blood brain barrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of lipid transport across blood brain barrier" EXACT [] +synonym: "up regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +synonym: "upregulation of lipid transport across blood brain barrier" EXACT [GOC:TermGenie] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0150201 ! positive regulation of transport across blood-brain barrier +is_a: GO:1903000 ! regulation of lipid transport across blood-brain barrier +relationship: positively_regulates GO:1990379 ! lipid transport across blood-brain barrier + +[Term] +id: GO:1903003 +name: positive regulation of protein deubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] +synonym: "activation of deubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein deubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of protein deubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of protein deubiquitylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of deubiquitination" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein deubiquitylation" EXACT [GOC:TermGenie] +synonym: "up regulation of deubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein deubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein deubiquitylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of deubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein deubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein deubiquitylation" EXACT [GOC:TermGenie] +synonym: "upregulation of deubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein deubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein deubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:0090085 ! regulation of protein deubiquitination +is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal +relationship: positively_regulates GO:0016579 ! protein deubiquitination + +[Term] +id: GO:1903004 +name: regulation of protein K63-linked deubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] +is_a: GO:0090085 ! regulation of protein deubiquitination +relationship: regulates GO:0070536 ! protein K63-linked deubiquitination + +[Term] +id: GO:1903005 +name: negative regulation of protein K63-linked deubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] +synonym: "down regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "inhibition of protein K63-linked deubiquitination" NARROW [GOC:TermGenie] +is_a: GO:0090086 ! negative regulation of protein deubiquitination +is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination +relationship: negatively_regulates GO:0070536 ! protein K63-linked deubiquitination + +[Term] +id: GO:1903006 +name: positive regulation of protein K63-linked deubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein K63-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] +synonym: "activation of protein K63-linked deubiquitination" NARROW [GOC:TermGenie] +synonym: "up regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of protein K63-linked deubiquitination" EXACT [GOC:TermGenie] +is_a: GO:1903003 ! positive regulation of protein deubiquitination +is_a: GO:1903004 ! regulation of protein K63-linked deubiquitination +relationship: positively_regulates GO:0070536 ! protein K63-linked deubiquitination + +[Term] +id: GO:1903007 +name: positive regulation of Lys63-specific deubiquitinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22970133] +synonym: "activation of Lys63-specific deubiquitinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Lys63-specific deubiquitinase activity" EXACT [GOC:TermGenie] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:1903006 ! positive regulation of protein K63-linked deubiquitination + +[Term] +id: GO:1903008 +name: organelle disassembly +namespace: biological_process +def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] +synonym: "organelle degradation" EXACT [] +is_a: GO:0006996 ! organelle organization +is_a: GO:0022411 ! cellular component disassembly + +[Term] +id: GO:1903009 +name: proteasome complex disassembly +namespace: biological_process +def: "The disaggregation of a proteasome complex into its constituent components." [GO_REF:0000079, GOC:TermGenie] +synonym: "26S proteasome disassembly" NARROW [GOC:TermGenie] +synonym: "proteasome degradation" EXACT [] +synonym: "proteasome disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:1903010 +name: regulation of bone development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0060348 ! bone development + +[Term] +id: GO:1903011 +name: negative regulation of bone development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] +synonym: "down regulation of bone development" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone development" EXACT [GOC:TermGenie] +synonym: "downregulation of bone development" EXACT [GOC:TermGenie] +synonym: "inhibition of bone development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903010 ! regulation of bone development +relationship: negatively_regulates GO:0060348 ! bone development + +[Term] +id: GO:1903012 +name: positive regulation of bone development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bone development." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:22510437] +synonym: "activation of bone development" NARROW [GOC:TermGenie] +synonym: "up regulation of bone development" EXACT [GOC:TermGenie] +synonym: "up-regulation of bone development" EXACT [GOC:TermGenie] +synonym: "upregulation of bone development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903010 ! regulation of bone development +relationship: positively_regulates GO:0060348 ! bone development + +[Term] +id: GO:1903013 +name: response to differentiation-inducing factor 1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144] +synonym: "DIF-1" RELATED [] +synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT [] +synonym: "response to DIF-1" RELATED [] +synonym: "response to DIF1" RELATED [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1903014 +name: cellular response to differentiation-inducing factor 1 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365144] +synonym: "cellular response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one" EXACT [] +synonym: "cellular response to DIF-1" RELATED [] +synonym: "cellular response to DIF1" RELATED [] +synonym: "DIF-1" RELATED [] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1903013 ! response to differentiation-inducing factor 1 + +[Term] +id: GO:1903015 +name: regulation of exo-alpha-sialidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) +synonym: "regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of sialidase activity" EXACT [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1903016 +name: negative regulation of exo-alpha-sialidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) +synonym: "down regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of acetylneuraminidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of alpha-neuraminidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of exo-alpha-sialidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of neuraminidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sialidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of sialidase activity" EXACT [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity + +[Term] +id: GO:1903017 +name: positive regulation of exo-alpha-sialidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exo-alpha-sialidase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) demonstrated in Figure 4A PMID:23544079, (IDA) +synonym: "activation of acetylneuraminidase activity" NARROW [GOC:TermGenie] +synonym: "activation of acetylneuraminyl hydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of alpha-neuraminidase activity" NARROW [GOC:TermGenie] +synonym: "activation of exo-alpha-sialidase activity" NARROW [GOC:TermGenie] +synonym: "activation of N-acylneuraminate glycohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of neuraminidase activity" NARROW [GOC:TermGenie] +synonym: "activation of sialidase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of sialidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylneuraminidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylneuraminyl hydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of exo-alpha-sialidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of N-acylneuraminate glycohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of neuraminidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of sialidase activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1903015 ! regulation of exo-alpha-sialidase activity + +[Term] +id: GO:1903018 +name: regulation of glycoprotein metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein +synonym: "regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:1903019 +name: negative regulation of glycoprotein metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein +synonym: "down regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of glycoprotein metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of glycoprotein metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1903018 ! regulation of glycoprotein metabolic process +relationship: negatively_regulates GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:1903020 +name: positive regulation of glycoprotein metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23544079] +comment: human serum amyloid P component (SAP) P02743 inhibits viral neuraminidase, NA (exo-alpha-sialidase activity) and thus the metabolism of glycoproteins, demonstrated in Figure 4A PMID:23544079, (IDA), the negative regulation term would be applied to this protein +synonym: "activation of glycoprotein metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of glycoprotein metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of glycoprotein metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of glycoprotein metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1903018 ! regulation of glycoprotein metabolic process +relationship: positively_regulates GO:0009100 ! glycoprotein metabolic process + +[Term] +id: GO:1903021 +name: regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1903022 +name: positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands." [GO_REF:0000059, GOC:rb, GOC:TermGenie, PMID:12192046] +synonym: "activation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" NARROW [GOC:TermGenie] +synonym: "up regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1903021 ! regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands + +[Term] +id: GO:1903023 +name: regulation of ascospore-type prospore membrane formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of formation of an ascospore-type prospore membrane." [GO_REF:0000058, GOC:TermGenie, PMID:11405625] +synonym: "regulation of ascospore-type prospore membrane assembly" RELATED [] +synonym: "regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of forespore membrane formation" EXACT [GOC:TermGenie] +synonym: "regulation of FSM assembly" EXACT [GOC:TermGenie] +synonym: "regulation of FSM biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of FSM formation" EXACT [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0032120 ! ascospore-type prospore membrane formation + +[Term] +id: GO:1903024 +name: positive regulation of ascospore-type prospore membrane formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of formation of an ascospore-type prospore membrane." [GO_REF:0000058, GOC:TermGenie, PMID:11405625] +synonym: "activation of ascospore-type prospore membrane assembly" NARROW [GOC:TermGenie] +synonym: "activation of forespore membrane biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of forespore membrane formation" NARROW [GOC:TermGenie] +synonym: "activation of FSM assembly" NARROW [GOC:TermGenie] +synonym: "activation of FSM biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of FSM formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ascospore-type prospore membrane assembly" RELATED [] +synonym: "positive regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of forespore membrane formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of FSM assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of FSM biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of FSM formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of forespore membrane formation" EXACT [GOC:TermGenie] +synonym: "up regulation of FSM assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of FSM biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of FSM formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of forespore membrane formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of FSM assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of FSM biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of FSM formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ascospore-type prospore membrane assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of forespore membrane biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of forespore membrane formation" EXACT [GOC:TermGenie] +synonym: "upregulation of FSM assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of FSM biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of FSM formation" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0075296 ! positive regulation of ascospore formation +is_a: GO:1903023 ! regulation of ascospore-type prospore membrane formation +relationship: positively_regulates GO:0032120 ! ascospore-type prospore membrane formation + +[Term] +id: GO:1903025 +name: regulation of RNA polymerase II regulatory region sequence-specific DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326] +is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1903026 +name: negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:dph, GOC:krc, GOC:TermGenie, PMID:20026326] +synonym: "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] +is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding +is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1903027 +name: regulation of opsonization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0008228 ! opsonization + +[Term] +id: GO:1903028 +name: positive regulation of opsonization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of opsonization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22333221] +synonym: "activation of opsonization" NARROW [GOC:TermGenie] +synonym: "up regulation of opsonization" EXACT [GOC:TermGenie] +synonym: "up-regulation of opsonization" EXACT [GOC:TermGenie] +synonym: "upregulation of opsonization" EXACT [GOC:TermGenie] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:1903027 ! regulation of opsonization +relationship: positively_regulates GO:0008228 ! opsonization + +[Term] +id: GO:1903031 +name: regulation of microtubule plus-end binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] +is_a: GO:1904526 ! regulation of microtubule binding + +[Term] +id: GO:1903032 +name: negative regulation of microtubule plus-end binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] +synonym: "down regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +synonym: "inhibition of microtubule plus-end binding" NARROW [GOC:TermGenie] +is_a: GO:1903031 ! regulation of microtubule plus-end binding +is_a: GO:1904527 ! negative regulation of microtubule binding + +[Term] +id: GO:1903033 +name: positive regulation of microtubule plus-end binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule plus-end binding." [GO_REF:0000059, GOC:hjd, GOC:TermGenie, PMID:16148041] +synonym: "activation of microtubule plus-end binding" NARROW [GOC:TermGenie] +synonym: "up regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule plus-end binding" EXACT [GOC:TermGenie] +is_a: GO:1903031 ! regulation of microtubule plus-end binding +is_a: GO:1904528 ! positive regulation of microtubule binding + +[Term] +id: GO:1903034 +name: regulation of response to wounding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] +synonym: "regulation of physiological response to wounding" EXACT [GOC:TermGenie] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0009611 ! response to wounding + +[Term] +id: GO:1903035 +name: negative regulation of response to wounding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] +synonym: "down regulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "down regulation of response to wounding" EXACT [GOC:TermGenie] +synonym: "down-regulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to wounding" EXACT [GOC:TermGenie] +synonym: "downregulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "downregulation of response to wounding" EXACT [GOC:TermGenie] +synonym: "inhibition of physiological response to wounding" NARROW [GOC:TermGenie] +synonym: "inhibition of response to wounding" NARROW [GOC:TermGenie] +synonym: "negative regulation of physiological response to wounding" EXACT [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1903034 ! regulation of response to wounding +relationship: negatively_regulates GO:0009611 ! response to wounding + +[Term] +id: GO:1903036 +name: positive regulation of response to wounding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to wounding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:19164535] +synonym: "activation of physiological response to wounding" NARROW [GOC:TermGenie] +synonym: "activation of response to wounding" NARROW [GOC:TermGenie] +synonym: "positive regulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "up regulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "up regulation of response to wounding" EXACT [GOC:TermGenie] +synonym: "up-regulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to wounding" EXACT [GOC:TermGenie] +synonym: "upregulation of physiological response to wounding" EXACT [GOC:TermGenie] +synonym: "upregulation of response to wounding" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1903034 ! regulation of response to wounding +relationship: positively_regulates GO:0009611 ! response to wounding + +[Term] +id: GO:1903037 +name: regulation of leukocyte cell-cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] +comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion +synonym: "regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:1903038 +name: negative regulation of leukocyte cell-cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] +comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion +synonym: "down regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "down regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "down regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +synonym: "inhibition of leukocyte adhesion" NARROW [GOC:TermGenie] +synonym: "inhibition of leukocyte cell adhesion" NARROW [GOC:TermGenie] +synonym: "inhibition of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] +synonym: "negative regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "negative regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: negatively_regulates GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:1903039 +name: positive regulation of leukocyte cell-cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21106532] +comment: Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion +synonym: "activation of leukocyte adhesion" NARROW [GOC:TermGenie] +synonym: "activation of leukocyte cell adhesion" NARROW [GOC:TermGenie] +synonym: "activation of leukocyte cell-cell adhesion" NARROW [GOC:TermGenie] +synonym: "positive regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "positive regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "up regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "up regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "up regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte adhesion" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte cell adhesion" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte cell-cell adhesion" EXACT [GOC:TermGenie] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: positively_regulates GO:0007159 ! leukocyte cell-cell adhesion + +[Term] +id: GO:1903040 +name: exon-exon junction complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an exon-exon junction complex." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:17606899] +synonym: "EJC assembly" EXACT [GOC:TermGenie] +synonym: "EJC formation" EXACT [GOC:TermGenie] +synonym: "exon-exon junction complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1903041 +name: regulation of chondrocyte hypertrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:0061181 ! regulation of chondrocyte development +relationship: regulates GO:0003415 ! chondrocyte hypertrophy + +[Term] +id: GO:1903042 +name: negative regulation of chondrocyte hypertrophy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] +synonym: "down regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +synonym: "down-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +synonym: "downregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +synonym: "inhibition of chondrocyte hypertrophy" NARROW [GOC:TermGenie] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:0061182 ! negative regulation of chondrocyte development +is_a: GO:1903041 ! regulation of chondrocyte hypertrophy +relationship: negatively_regulates GO:0003415 ! chondrocyte hypertrophy + +[Term] +id: GO:1903043 +name: positive regulation of chondrocyte hypertrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:23928032] +synonym: "activation of chondrocyte hypertrophy" NARROW [GOC:TermGenie] +synonym: "up regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +synonym: "up-regulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +synonym: "upregulation of chondrocyte hypertrophy" EXACT [GOC:TermGenie] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1902761 ! positive regulation of chondrocyte development +is_a: GO:1903041 ! regulation of chondrocyte hypertrophy +relationship: positively_regulates GO:0003415 ! chondrocyte hypertrophy + +[Term] +id: GO:1903044 +name: protein localization to membrane raft +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a membrane raft." [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744] +synonym: "protein localisation in membrane raft" EXACT [GOC:TermGenie] +synonym: "protein localisation to membrane raft" EXACT [GOC:TermGenie] +synonym: "protein localization in membrane raft" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1903045 +name: neural crest cell migration involved in sympathetic nervous system development +namespace: biological_process +def: "Any neural crest cell migration that is involved in sympathetic nervous system development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19325129] +comment: Sema3a (O08665, mouse) is involved in neural crest cell migration involved in sympathetic nervous system development +is_a: GO:1901166 ! neural crest cell migration involved in autonomic nervous system development +relationship: part_of GO:0048485 ! sympathetic nervous system development + +[Term] +id: GO:1903046 +name: meiotic cell cycle process +namespace: biological_process +def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +subset: gocheck_do_not_annotate +subset: goslim_pombe +is_a: GO:0022402 ! cell cycle process +is_a: GO:0022414 ! reproductive process +relationship: part_of GO:0051321 ! meiotic cell cycle + +[Term] +id: GO:1903047 +name: mitotic cell cycle process +namespace: biological_process +def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +subset: gocheck_do_not_annotate +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000278 ! mitotic cell cycle + +[Term] +id: GO:1903048 +name: regulation of acetylcholine-gated cation channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690] +is_a: GO:0098815 ! modulation of excitatory postsynaptic potential +is_a: GO:0098962 ! regulation of postsynaptic neurotransmitter receptor activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1903049 +name: negative regulation of acetylcholine-gated cation channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine-gated cation channel activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21718690] +synonym: "down regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine-gated cation channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of acetylcholine-gated cation channel activity" NARROW [GOC:TermGenie] +is_a: GO:1903048 ! regulation of acetylcholine-gated cation channel activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1903050 +name: regulation of proteolysis involved in cellular protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] +comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) +synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +is_a: GO:0030162 ! regulation of proteolysis +is_a: GO:1903362 ! regulation of cellular protein catabolic process +relationship: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:1903051 +name: negative regulation of proteolysis involved in cellular protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] +comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP). +synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +is_a: GO:0045861 ! negative regulation of proteolysis +is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process +is_a: GO:1903363 ! negative regulation of cellular protein catabolic process +relationship: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:1903052 +name: positive regulation of proteolysis involved in cellular protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] +comment: overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) +synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] +is_a: GO:0045862 ! positive regulation of proteolysis +is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process +is_a: GO:1903364 ! positive regulation of cellular protein catabolic process +relationship: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process + +[Term] +id: GO:1903053 +name: regulation of extracellular matrix organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] +synonym: "regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:1903054 +name: negative regulation of extracellular matrix organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] +synonym: "down regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "down regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of extracellular matrix organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of extracellular matrix organization" NARROW [GOC:TermGenie] +synonym: "inhibition of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: negatively_regulates GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:1903055 +name: positive regulation of extracellular matrix organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extracellular matrix organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:22357537] +synonym: "activation of extracellular matrix organisation" NARROW [GOC:TermGenie] +synonym: "activation of extracellular matrix organization" NARROW [GOC:TermGenie] +synonym: "activation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "up regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of extracellular matrix organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular matrix organization" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular matrix organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: positively_regulates GO:0030198 ! extracellular matrix organization + +[Term] +id: GO:1903056 +name: regulation of melanosome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] +comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles +synonym: "regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0032438 ! melanosome organization + +[Term] +id: GO:1903057 +name: negative regulation of melanosome organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] +comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. +synonym: "down regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "down regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "downregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of melanosome organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of melanosome organization" NARROW [GOC:TermGenie] +synonym: "inhibition of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1903056 ! regulation of melanosome organization +relationship: negatively_regulates GO:0032438 ! melanosome organization + +[Term] +id: GO:1903058 +name: positive regulation of melanosome organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of melanosome organization." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24769727] +comment: Lack of the transcription factor Zeb2 Q9R0G7 leads to spherical melanosomes with irregular borders, in contrast to the rod-shaped melanosomes of ZEB2MCWT hair follicles. +synonym: "activation of melanosome organisation" NARROW [GOC:TermGenie] +synonym: "activation of melanosome organization" NARROW [GOC:TermGenie] +synonym: "activation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "up regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of melanosome organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of melanosome organization" EXACT [GOC:TermGenie] +synonym: "upregulation of melanosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1903056 ! regulation of melanosome organization +relationship: positively_regulates GO:0032438 ! melanosome organization + +[Term] +id: GO:1903059 +name: regulation of protein lipidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] +synonym: "regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:0050746 ! regulation of lipoprotein metabolic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0006497 ! protein lipidation + +[Term] +id: GO:1903060 +name: negative regulation of protein lipidation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] +synonym: "down regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "down regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein lipidation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein lipidation" EXACT [GOC:TermGenie] +synonym: "downregulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "downregulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein lipidation" EXACT [GOC:TermGenie] +synonym: "inhibition of lipid:protein modification" NARROW [GOC:TermGenie] +synonym: "inhibition of protein amino acid lipidation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein lipidation" NARROW [GOC:TermGenie] +synonym: "negative regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0050748 ! negative regulation of lipoprotein metabolic process +is_a: GO:1903059 ! regulation of protein lipidation +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0006497 ! protein lipidation + +[Term] +id: GO:1903061 +name: positive regulation of protein lipidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein lipidation." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:21909394] +synonym: "activation of lipid:protein modification" NARROW [GOC:TermGenie] +synonym: "activation of protein amino acid lipidation" NARROW [GOC:TermGenie] +synonym: "activation of protein lipidation" NARROW [GOC:TermGenie] +synonym: "positive regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "up regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "up regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein lipidation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein lipidation" EXACT [GOC:TermGenie] +synonym: "upregulation of lipid:protein modification" EXACT [GOC:TermGenie] +synonym: "upregulation of protein amino acid lipidation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein lipidation" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:0050747 ! positive regulation of lipoprotein metabolic process +is_a: GO:1903059 ! regulation of protein lipidation +relationship: positively_regulates GO:0006497 ! protein lipidation + +[Term] +id: GO:1903062 +name: regulation of reverse cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] +is_a: GO:0032374 ! regulation of cholesterol transport +relationship: regulates GO:0043691 ! reverse cholesterol transport + +[Term] +id: GO:1903063 +name: negative regulation of reverse cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] +synonym: "down regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +synonym: "downregulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +synonym: "inhibition of reverse cholesterol transport" NARROW [GOC:TermGenie] +is_a: GO:0032375 ! negative regulation of cholesterol transport +is_a: GO:1903062 ! regulation of reverse cholesterol transport +relationship: negatively_regulates GO:0043691 ! reverse cholesterol transport + +[Term] +id: GO:1903064 +name: positive regulation of reverse cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of reverse cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:23931754] +synonym: "activation of reverse cholesterol transport" NARROW [GOC:TermGenie] +synonym: "up regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +synonym: "upregulation of reverse cholesterol transport" EXACT [GOC:TermGenie] +is_a: GO:0032376 ! positive regulation of cholesterol transport +is_a: GO:1903062 ! regulation of reverse cholesterol transport +relationship: positively_regulates GO:0043691 ! reverse cholesterol transport + +[Term] +id: GO:1903065 +name: obsolete protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape +namespace: biological_process +def: "OBSOLETE. Any protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903066 +name: regulation of protein localization to cell tip +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] +synonym: "regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1903067 +name: negative regulation of protein localization to cell tip +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] +synonym: "down regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to cell tip" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell tip" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell tip" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to cell tip" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to cell tip" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903066 ! regulation of protein localization to cell tip +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1903068 +name: positive regulation of protein localization to cell tip +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell tip." [GO_REF:0000058, GOC:TermGenie, PMID:24554432] +synonym: "activation of protein localisation to cell tip" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to cell tip" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to cell tip" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cell tip" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to cell tip" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cell tip" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903066 ! regulation of protein localization to cell tip +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1903069 +name: regulation of ER-associated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] +synonym: "regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of ERAD" EXACT [GOC:TermGenie] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1904292 ! regulation of ERAD pathway +relationship: regulates GO:0030433 ! ubiquitin-dependent ERAD pathway + +[Term] +id: GO:1903070 +name: negative regulation of ER-associated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] +synonym: "down regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ERAD" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERAD" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ERAD" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ER-associated protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of ER-associated protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ER-associated protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ER-associated protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ERAD" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ERAD" EXACT [GOC:TermGenie] +is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process +is_a: GO:1904293 ! negative regulation of ERAD pathway +relationship: negatively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway + +[Term] +id: GO:1903071 +name: positive regulation of ER-associated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process." [GO_REF:0000058, GOC:rph, GOC:TermGenie, PMID:17872946] +synonym: "activation of endoplasmic reticulum-associated protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum-associated protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of ER-associated protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of ER-associated protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ER-associated protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of ER-associated protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of ER-associated ubiquitin-dependent protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ERAD" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ERAD" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ERAD" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERAD" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ER-associated protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of ER-associated protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ER-associated protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ER-associated protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ERAD" EXACT [GOC:TermGenie] +is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1903069 ! regulation of ER-associated ubiquitin-dependent protein catabolic process +is_a: GO:1904294 ! positive regulation of ERAD pathway +relationship: positively_regulates GO:0030433 ! ubiquitin-dependent ERAD pathway + +[Term] +id: GO:1903072 +name: regulation of death-inducing signaling complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] +synonym: "regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] +synonym: "regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of DISC assembly" EXACT [GOC:TermGenie] +synonym: "regulation of DISC formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0071550 ! death-inducing signaling complex assembly + +[Term] +id: GO:1903073 +name: negative regulation of death-inducing signaling complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] +synonym: "down regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of DISC assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of DISC formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of DISC assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of DISC formation" EXACT [GOC:TermGenie] +synonym: "downregulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of death-inducing signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of DISC assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of DISC formation" EXACT [GOC:TermGenie] +synonym: "inhibition of DD-mediated complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of death domain-mediated complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of death-inducing signaling complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of death-inducing signaling complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of death-inducing signalling complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of DISC assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of DISC formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of DD-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of death domain-mediated complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of DISC assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of DISC formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1903072 ! regulation of death-inducing signaling complex assembly +is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0071550 ! death-inducing signaling complex assembly + +[Term] +id: GO:1903074 +name: TRAIL death-inducing signaling complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] +synonym: "TRAIL death-inducing signaling complex formation" EXACT [GOC:TermGenie] +synonym: "TRAIL death-inducing signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "TRAIL death-inducing signalling complex formation" EXACT [GOC:TermGenie] +synonym: "TRAIL DISC assembly" EXACT [GOC:TermGenie] +synonym: "TRAIL DISC formation" EXACT [GOC:TermGenie] +is_a: GO:0071550 ! death-inducing signaling complex assembly +relationship: part_of GO:0036462 ! TRAIL-activated apoptotic signaling pathway + +[Term] +id: GO:1903075 +name: pyridoxine import across plasma membrane +namespace: biological_process +def: "The directed movement of pyridoxine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:15701794] +synonym: "pyridoxine import into cell" EXACT [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1903092 ! pyridoxine transmembrane transport + +[Term] +id: GO:1903076 +name: regulation of protein localization to plasma membrane +namespace: biological_process +alt_id: GO:0090003 +alt_id: GO:1905963 +def: "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] +synonym: "regulation of establishment of protein localization in plasma membrane" RELATED [] +synonym: "regulation of establishment of protein localization to plasma membrane" RELATED [] +synonym: "regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] +synonym: "regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein targeting to plasma membrane" RELATED [] +synonym: "regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +is_a: GO:1904375 ! regulation of protein localization to cell periphery +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0072659 ! protein localization to plasma membrane + +[Term] +id: GO:1903077 +name: negative regulation of protein localization to plasma membrane +namespace: biological_process +alt_id: GO:0090005 +alt_id: GO:1905964 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "down regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "down regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "downregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "downregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "inhibition of protein localisation in plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein targeting to plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein-plasma membrane targeting" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] +synonym: "negative regulation of establishment of protein localization in plasma membrane" RELATED [] +synonym: "negative regulation of establishment of protein localization to plasma membrane" RELATED [] +synonym: "negative regulation of protein localisation in plasma membrane" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein targeting to plasma membrane" RELATED [] +synonym: "negative regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +is_a: GO:1903076 ! regulation of protein localization to plasma membrane +is_a: GO:1904376 ! negative regulation of protein localization to cell periphery +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:0072659 ! protein localization to plasma membrane + +[Term] +id: GO:1903078 +name: positive regulation of protein localization to plasma membrane +namespace: biological_process +alt_id: GO:0090004 +alt_id: GO:1905965 +def: "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "activation of protein localisation in plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein targeting to plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein-plasma membrane targeting" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localisation in plasma membrane" RELATED [GOC:mah] +synonym: "positive regulation of establishment of protein localization to plasma membrane" RELATED [] +synonym: "positive regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein targeting to plasma membrane" RELATED [] +synonym: "positive regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "up regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "up regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +synonym: "upregulation of protein localisation in plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein targeting to plasma membrane" RELATED [GOC:TermGenie] +synonym: "upregulation of protein-plasma membrane targeting" RELATED [GOC:TermGenie] +is_a: GO:1903076 ! regulation of protein localization to plasma membrane +is_a: GO:1904377 ! positive regulation of protein localization to cell periphery +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:0072659 ! protein localization to plasma membrane + +[Term] +id: GO:1903079 +name: obsolete negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape +namespace: biological_process +def: "OBSOLETE. Any negative regulation of protein localization to cell tip that is involved in positive regulation of establishment of cell polarity regulating cell shape." [GO_REF:0000060, GOC:TermGenie, PMID:24554432] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization to cell tip involved in positive regulation of establishment of cell polarity regulating cell shape" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903080 +name: regulation of C-C chemokine receptor CCR7 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0070099 ! regulation of chemokine-mediated signaling pathway +relationship: regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway + +[Term] +id: GO:1903081 +name: negative regulation of C-C chemokine receptor CCR7 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "down regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0070100 ! negative regulation of chemokine-mediated signaling pathway +is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway +relationship: negatively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway + +[Term] +id: GO:1903082 +name: positive regulation of C-C chemokine receptor CCR7 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] +synonym: "activation of C-C chemokine receptor CCR7 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of C-C chemokine receptor CCR7 signalling pathway" NARROW [GOC:TermGenie] +synonym: "activation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of C-C chemokine receptor CCR7 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of C-C chemokine receptor CCR7 signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of CCR7 signaling pathway" RELATED [GOC:TermGenie] +is_a: GO:0070101 ! positive regulation of chemokine-mediated signaling pathway +is_a: GO:1903080 ! regulation of C-C chemokine receptor CCR7 signaling pathway +relationship: positively_regulates GO:0038118 ! C-C chemokine receptor CCR7 signaling pathway + +[Term] +id: GO:1903083 +name: protein localization to condensed chromosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] +synonym: "protein localisation in condensed chromosome" EXACT [GOC:TermGenie] +synonym: "protein localisation to condensed chromosome" EXACT [GOC:TermGenie] +synonym: "protein localization in condensed chromosome" EXACT [GOC:TermGenie] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:1903084 +name: protein localization to condensed nuclear chromosome +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] +synonym: "protein localisation in condensed nuclear chromosome" EXACT [GOC:TermGenie] +synonym: "protein localisation to condensed nuclear chromosome" EXACT [GOC:TermGenie] +synonym: "protein localization in condensed nuclear chromosome" EXACT [GOC:TermGenie] +is_a: GO:0034504 ! protein localization to nucleus +is_a: GO:1903083 ! protein localization to condensed chromosome + +[Term] +id: GO:1903085 +name: regulation of sinapate ester biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161] +synonym: "regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of sinapate ester formation" EXACT [GOC:TermGenie] +synonym: "regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process +relationship: regulates GO:0033525 ! sinapate ester biosynthetic process + +[Term] +id: GO:1903086 +name: negative regulation of sinapate ester biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:11080161] +synonym: "down regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of sinapate ester formation" EXACT [GOC:TermGenie] +synonym: "down regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of sinapate ester formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sinapate ester anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sinapate ester biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of sinapate ester formation" EXACT [GOC:TermGenie] +synonym: "downregulation of sinapate ester synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sinapate ester anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of sinapate ester biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of sinapate ester biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of sinapate ester formation" NARROW [GOC:TermGenie] +synonym: "inhibition of sinapate ester synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of sinapate ester anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of sinapate ester biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of sinapate ester formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of sinapate ester synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1900377 ! negative regulation of secondary metabolite biosynthetic process +is_a: GO:1903085 ! regulation of sinapate ester biosynthetic process +relationship: negatively_regulates GO:0033525 ! sinapate ester biosynthetic process + +[Term] +id: GO:1903087 +name: mitotic spindle pole body duplication +namespace: biological_process +def: "Any spindle pole body duplication that is involved in the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "spindle pole body assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body biogenesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body biosynthesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body duplication associated with nuclear envelope involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body duplication in cytoplasm involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body duplication involved in mitotic cell cycle" EXACT [] +synonym: "spindle pole body formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "spindle pole body replication involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0030474 ! spindle pole body duplication +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:1903088 +name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport +namespace: biological_process +def: "The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24778186] +is_a: GO:0042886 ! amide transport +is_a: GO:0045117 ! azole transmembrane transport +is_a: GO:1901264 ! carbohydrate derivative transport + +[Term] +id: GO:1903089 +name: 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other." [GO_REF:0000066, GOC:TermGenie, PMID:24778186] +synonym: "acadesine transporter activity" EXACT [] +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity +is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity + +[Term] +id: GO:1903090 +name: pyridoxal transmembrane transport +namespace: biological_process +def: "The process in which pyridoxal is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] +is_a: GO:0031920 ! pyridoxal transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1903091 +name: pyridoxamine transmembrane transport +namespace: biological_process +def: "The process in which pyridoxamine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] +is_a: GO:0031922 ! pyridoxamine transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1903092 +name: pyridoxine transmembrane transport +namespace: biological_process +def: "The process in which pyridoxine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15701794] +is_a: GO:0031923 ! pyridoxine transport +is_a: GO:0035461 ! vitamin transmembrane transport + +[Term] +id: GO:1903093 +name: regulation of protein K48-linked deubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +is_a: GO:0090085 ! regulation of protein deubiquitination +relationship: regulates GO:0071108 ! protein K48-linked deubiquitination + +[Term] +id: GO:1903094 +name: negative regulation of protein K48-linked deubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein K48-linked deubiquitination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21097510] +synonym: "down regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein K48-linked deubiquitination" EXACT [GOC:TermGenie] +synonym: "inhibition of protein K48-linked deubiquitination" NARROW [GOC:TermGenie] +is_a: GO:0090086 ! negative regulation of protein deubiquitination +is_a: GO:1903093 ! regulation of protein K48-linked deubiquitination +relationship: negatively_regulates GO:0071108 ! protein K48-linked deubiquitination + +[Term] +id: GO:1903095 +name: ribonuclease III complex +namespace: cellular_component +def: "A protein complex which is capable of ribonuclease III activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22393237] +comment: An example of this is RNC in human (Q9NRR4) in PMID:22393237 (inferred from direct assay). +is_a: GO:1902555 ! endoribonuclease complex + +[Term] +id: GO:1903096 +name: protein localization to meiotic spindle midzone +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle midzone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] +synonym: "protein localisation in meiotic spindle midzone" EXACT [GOC:TermGenie] +synonym: "protein localisation to meiotic spindle midzone" EXACT [GOC:TermGenie] +synonym: "protein localization in meiotic spindle midzone" EXACT [GOC:TermGenie] +is_a: GO:1905359 ! protein localization to meiotic spindle + +[Term] +id: GO:1903097 +name: regulation of CENP-A containing nucleosome assembly +namespace: biological_process +def: "Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] +synonym: "regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +is_a: GO:0010847 ! regulation of chromatin assembly +is_a: GO:0090230 ! regulation of centromere complex assembly +is_a: GO:1900049 ! regulation of histone exchange +relationship: regulates GO:0034080 ! CENP-A containing chromatin assembly + +[Term] +id: GO:1903098 +name: negative regulation of CENP-A containing nucleosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] +synonym: "down regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "down regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "down regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "down regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "down regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "down regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "down regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "down-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "down-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "down-regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "down-regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "down-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "down-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "down-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "downregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "downregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "downregulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "downregulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "downregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "downregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "downregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "inhibition of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "inhibition of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie] +synonym: "inhibition of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "inhibition of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "inhibition of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "inhibition of centromere-specific histone exchange" NARROW [GOC:TermGenie] +synonym: "inhibition of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie] +synonym: "negative regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "negative regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "negative regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "negative regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "negative regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "negative regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly +is_a: GO:1900050 ! negative regulation of histone exchange +is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly +relationship: negatively_regulates GO:0034080 ! CENP-A containing chromatin assembly + +[Term] +id: GO:1903099 +name: positive regulation of CENP-A containing nucleosome assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GO_REF:0000058, GOC:TermGenie, PMID:24710126] +synonym: "activation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "activation of CENP-A containing nucleosome assembly at centromere" NARROW [GOC:TermGenie] +synonym: "activation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "activation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "activation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "activation of centromere-specific histone exchange" NARROW [GOC:TermGenie] +synonym: "activation of centromere-specific nucleosome assembly" NARROW [GOC:TermGenie] +synonym: "activation of centromeric DNA replication-independent nucleosome assembly" NARROW [GOC:TermGenie] +synonym: "activation of DNA replication-independent nucleosome assembly at centromere" NARROW [GOC:TermGenie] +synonym: "positive regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "positive regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "positive regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "positive regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "positive regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "positive regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "up regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "up regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "up regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "up regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "up regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "up regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "up regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "up-regulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "up-regulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "up-regulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "up-regulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "up-regulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "up-regulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "up-regulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "upregulation of CenH3-containing nucleosome assembly at centromere" RELATED [GOC:TermGenie] +synonym: "upregulation of CENP-A containing nucleosome assembly at centromere" EXACT [GOC:TermGenie] +synonym: "upregulation of CENP-A deposition" RELATED [GOC:TermGenie] +synonym: "upregulation of CENP-A loading" RELATED [GOC:TermGenie] +synonym: "upregulation of centromere specific nucleosome exchange" RELATED [GOC:TermGenie] +synonym: "upregulation of centromere-specific histone exchange" EXACT [GOC:TermGenie] +synonym: "upregulation of centromere-specific nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly +is_a: GO:1900051 ! positive regulation of histone exchange +is_a: GO:1903097 ! regulation of CENP-A containing nucleosome assembly +relationship: positively_regulates GO:0034080 ! CENP-A containing chromatin assembly + +[Term] +id: GO:1903100 +name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:1903101 +name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate breakdown" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate catabolism" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate degradation" EXACT [GOC:TermGenie] +is_a: GO:0031161 ! phosphatidylinositol catabolic process +is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process + +[Term] +id: GO:1903102 +name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [GO_REF:0000068, GOC:bhm, GOC:TermGenie, PMID:19037259] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate anabolism" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate formation" EXACT [GOC:TermGenie] +synonym: "1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process +is_a: GO:1903100 ! 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process + +[Term] +id: GO:1903103 +name: potassium:proton antiporter complex +namespace: cellular_component +def: "A protein complex which is capable of potassium:proton antiporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:21041667] +comment: An example of this is kefC in E. coli (P03819) in PMID:21041667 (inferred from direct assay). +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1903104 +name: regulation of insulin receptor signaling pathway involved in determination of adult lifespan +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] +synonym: "regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +is_a: GO:0046626 ! regulation of insulin receptor signaling pathway +relationship: regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan + +[Term] +id: GO:1903105 +name: negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] +synonym: "down regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "down regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "down regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "down regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "down-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "down-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "downregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "downregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "downregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "downregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "inhibition of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "inhibition of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "inhibition of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "inhibition of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "negative regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "negative regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +is_a: GO:0046627 ! negative regulation of insulin receptor signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan +relationship: negatively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan + +[Term] +id: GO:1903106 +name: positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:19853560] +synonym: "activation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "activation of insulin receptor signaling pathway involved in determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "activation of insulin receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "activation of insulin receptor signalling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "positive regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "positive regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "up regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up-regulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "up-regulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "upregulation of daf-2 receptor signaling pathway of determination of adult lifespan" NARROW [GOC:TermGenie] +synonym: "upregulation of insulin receptor signaling pathway involved in determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "upregulation of insulin receptor signaling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +synonym: "upregulation of insulin receptor signalling pathway of determination of adult lifespan" EXACT [GOC:TermGenie] +is_a: GO:0046628 ! positive regulation of insulin receptor signaling pathway +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903104 ! regulation of insulin receptor signaling pathway involved in determination of adult lifespan +relationship: positively_regulates GO:1901047 ! insulin receptor signaling pathway involved in determination of adult lifespan + +[Term] +id: GO:1903107 +name: insulin receptor signaling pathway involved in dauer larval development +namespace: biological_process +def: "Any insulin receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19853560] +synonym: "daf-2 receptor signaling pathway involved in dauer larval development" NARROW [GOC:TermGenie] +synonym: "insulin receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +is_a: GO:0008286 ! insulin receptor signaling pathway +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:1903108 +name: regulation of mitochondrial transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] +synonym: "regulation of transcription from mitochondrial promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +is_a: GO:0062125 ! regulation of mitochondrial gene expression +relationship: regulates GO:0006390 ! mitochondrial transcription + +[Term] +id: GO:1903109 +name: positive regulation of mitochondrial transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription occuring in the mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:21357609] +synonym: "activation of mitochondrial transcription" NARROW [GOC:TermGenie] +synonym: "activation of transcription from mitochondrial promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of transcription from mitochondrial promoter" EXACT [] +synonym: "up regulation of mitochondrial transcription" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial transcription" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial transcription" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from mitochondrial promoter" EXACT [GOC:TermGenie] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:1903108 ! regulation of mitochondrial transcription +relationship: positively_regulates GO:0006390 ! mitochondrial transcription + +[Term] +id: GO:1903110 +name: regulation of single-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] +is_a: GO:0000018 ! regulation of DNA recombination +is_a: GO:1903516 ! regulation of single strand break repair +relationship: regulates GO:1990396 ! single-strand break repair via homologous recombination + +[Term] +id: GO:1903111 +name: negative regulation of single-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] +synonym: "down regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "down-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "downregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "inhibition of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie] +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination +is_a: GO:1903517 ! negative regulation of single strand break repair +relationship: negatively_regulates GO:1990396 ! single-strand break repair via homologous recombination + +[Term] +id: GO:1903112 +name: positive regulation of single-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of single-strand break repair via homologous recombination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:24339919] +synonym: "activation of single-strand break repair via homologous recombination" NARROW [GOC:TermGenie] +synonym: "up regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "up-regulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "upregulation of single-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:1903110 ! regulation of single-strand break repair via homologous recombination +is_a: GO:1903518 ! positive regulation of single strand break repair +relationship: positively_regulates GO:1990396 ! single-strand break repair via homologous recombination + +[Term] +id: GO:1903113 +name: copper ion transmembrane transporter complex +namespace: cellular_component +def: "A protein complex which is capable of copper ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23122209] +comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209 (inferred from direct assay). +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1903114 +name: silver ion transmembrane transporter complex +namespace: cellular_component +def: "A protein complex which is capable of silver ion transmembrane transporter activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11283292] +comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:11283292 (inferred from direct assay). +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1903115 +name: regulation of actin filament-based movement +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] +is_a: GO:0032970 ! regulation of actin filament-based process +is_a: GO:0051270 ! regulation of cellular component movement +relationship: regulates GO:0030048 ! actin filament-based movement + +[Term] +id: GO:1903116 +name: positive regulation of actin filament-based movement +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament-based movement." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] +synonym: "activation of actin filament-based movement" NARROW [GOC:TermGenie] +synonym: "up regulation of actin filament-based movement" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament-based movement" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament-based movement" EXACT [GOC:TermGenie] +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: positively_regulates GO:0030048 ! actin filament-based movement + +[Term] +id: GO:1903117 +name: regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in cytokinetic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24798735] +synonym: "regulation of actin filament organisation of constriction ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organisation of contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "regulation of actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organization of constriction ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organization of contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "regulation of actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of constriction ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of contractile ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0110053 ! regulation of actin filament organization +relationship: regulates GO:2000689 ! actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903118 +name: urate homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of urate within an organism or cell." [GO_REF:0000072, GOC:dph, GOC:TermGenie, PMID:22306318] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:1903119 +name: protein localization to actin cytoskeleton +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] +synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] +synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] +synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] +is_a: GO:0044380 ! protein localization to cytoskeleton + +[Term] +id: GO:1903120 +name: protein localization to actin filament bundle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] +synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] +synonym: "protein localization to actin cable" RELATED [GOC:mah] +is_a: GO:1903119 ! protein localization to actin cytoskeleton + +[Term] +id: GO:1903121 +name: regulation of TRAIL-activated apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1902041 ! regulation of extrinsic apoptotic signaling pathway via death domain receptors +relationship: regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway + +[Term] +id: GO:1903122 +name: negative regulation of TRAIL-activated apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21785459] +synonym: "down regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1902042 ! negative regulation of extrinsic apoptotic signaling pathway via death domain receptors +is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway +relationship: negatively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway + +[Term] +id: GO:1903123 +name: regulation of thioredoxin peroxidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of TPx activity" EXACT [GOC:TermGenie] +synonym: "regulation of TrxPx activity" EXACT [GOC:TermGenie] +is_a: GO:2000468 ! regulation of peroxidase activity + +[Term] +id: GO:1903124 +name: negative regulation of thioredoxin peroxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thioredoxin peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687] +synonym: "down regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of TPx activity" EXACT [GOC:TermGenie] +synonym: "down regulation of TrxPx activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of TPx activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of TrxPx activity" EXACT [GOC:TermGenie] +synonym: "downregulation of thiol peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of thioredoxin peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of TPx activity" EXACT [GOC:TermGenie] +synonym: "downregulation of TrxPx activity" EXACT [GOC:TermGenie] +synonym: "inhibition of thiol peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of thioredoxin peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of TPx activity" NARROW [GOC:TermGenie] +synonym: "inhibition of TrxPx activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of thiol peroxidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of TPx activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of TrxPx activity" EXACT [GOC:TermGenie] +is_a: GO:1903123 ! regulation of thioredoxin peroxidase activity +is_a: GO:2000469 ! negative regulation of peroxidase activity + +[Term] +id: GO:1903125 +name: negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation +namespace: biological_process +def: "A peptidyl-threonine phosphorylation that results in negative regulation of thioredoxin peroxidase activity." [GO_REF:0000063, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21850687] +synonym: "negative regulation of thiol peroxidase activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TrxPx activity by peptidyl-threonine phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0018107 ! peptidyl-threonine phosphorylation + +[Term] +id: GO:1903126 +name: negative regulation of centriole-centriole cohesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434] +synonym: "down regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +synonym: "downregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +synonym: "inhibition of centriole-centriole cohesion" NARROW [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0030997 ! regulation of centriole-centriole cohesion +relationship: negatively_regulates GO:0010457 ! centriole-centriole cohesion + +[Term] +id: GO:1903127 +name: positive regulation of centriole-centriole cohesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centriole-centriole cohesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24554434] +synonym: "activation of centriole-centriole cohesion" NARROW [GOC:TermGenie] +synonym: "up regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +synonym: "upregulation of centriole-centriole cohesion" EXACT [GOC:TermGenie] +is_a: GO:0030997 ! regulation of centriole-centriole cohesion +is_a: GO:0090068 ! positive regulation of cell cycle process +relationship: positively_regulates GO:0010457 ! centriole-centriole cohesion + +[Term] +id: GO:1903131 +name: mononuclear cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell." [CL:0000842, GO_REF:0000086, GOC:TermGenie, PMID:24759906] +is_a: GO:0002521 ! leukocyte differentiation + +[Term] +id: GO:1903132 +name: regulation of tube lumen cavitation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060605 ! tube lumen cavitation + +[Term] +id: GO:1903133 +name: negative regulation of tube lumen cavitation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22898778] +synonym: "inhibition of tube lumen cavitation" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903132 ! regulation of tube lumen cavitation +relationship: negatively_regulates GO:0060605 ! tube lumen cavitation + +[Term] +id: GO:1903134 +name: obsolete trehalose catabolic process involved in cellular response to stress +namespace: biological_process +def: "OBSOLETE. Any trehalose catabolic process that is involved in cellular response to stress." [GO_REF:0000060, GOC:TermGenie, PMID:15965643] +comment: This term was obsoleted because it does not represent a specific pathway. +synonym: "mycose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "mycose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "mykose catabolic process involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "mykose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "trehalose breakdown involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "trehalose catabolism involved in cellular response to stress" EXACT [GOC:TermGenie] +synonym: "trehalose degradation involved in cellular response to stress" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903135 +name: cupric ion binding +namespace: molecular_function +def: "Binding to a cupric ion, copper(2+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322] +synonym: "copper(2+)binding" EXACT [CHEBI:29036] +synonym: "Cu(2+) binding" EXACT [CHEBI:29036] +synonym: "Cu(II) binding" EXACT [PMID:24567322] +is_a: GO:0005507 ! copper ion binding + +[Term] +id: GO:1903136 +name: cuprous ion binding +namespace: molecular_function +def: "Binding to a cuprous ion, copper(1+)." [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322] +synonym: "copper(1+) binding" EXACT [CHEBI:49552] +synonym: "Cu(+) binding" EXACT [CHEBI:49552] +synonym: "Cu(I) binding" EXACT [PMID:24567322] +is_a: GO:0005507 ! copper ion binding + +[Term] +id: GO:1903137 +name: regulation of cell wall integrity MAPK cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] +synonym: "regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [] +synonym: "regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "regulation of Slt2 cascade" NARROW [GOC:TermGenie] +is_a: GO:0032872 ! regulation of stress-activated MAPK cascade +relationship: regulates GO:0000196 ! cell wall integrity MAPK cascade + +[Term] +id: GO:1903138 +name: negative regulation of cell wall integrity MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] +synonym: "down regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "down regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "down regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "down regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "down regulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "down-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "down-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "down-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "down-regulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "downregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "downregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "downregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "downregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "downregulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of cell integrity MAPK pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [] +synonym: "negative regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "negative regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "negative regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of Slt2 cascade" NARROW [GOC:TermGenie] +is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade +is_a: GO:1903137 ! regulation of cell wall integrity MAPK cascade +relationship: negatively_regulates GO:0000196 ! cell wall integrity MAPK cascade + +[Term] +id: GO:1903139 +name: positive regulation of cell wall integrity MAPK cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23934882] +synonym: "activation of cell integrity MAPK pathway" NARROW [GOC:TermGenie] +synonym: "activation of cell wall biogenesis, MAPKKK cascade" NARROW [GOC:TermGenie] +synonym: "activation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of MAPK cascade involved in cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of MAPKKK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "activation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "activation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "activation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "activation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "positive regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "positive regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [] +synonym: "positive regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "positive regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "positive regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "up regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "up regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "up regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "up-regulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "up-regulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "up-regulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of Slt2 cascade" NARROW [GOC:TermGenie] +synonym: "upregulation of cell integrity MAPK pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of cell wall biogenesis, MAPKKK cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of MAPK cascade involved in cell wall biogenesis" NARROW [GOC:TermGenie] +synonym: "upregulation of MAPK cascade involved in cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Mpk1 cascade" NARROW [GOC:TermGenie] +synonym: "upregulation of Pmk1 MAPK cell integrity signaling" NARROW [GOC:TermGenie] +synonym: "upregulation of Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of PMK1-MAPK signal transduction pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of Slt2 cascade" NARROW [GOC:TermGenie] +is_a: GO:0032874 ! positive regulation of stress-activated MAPK cascade +is_a: GO:1903137 ! regulation of cell wall integrity MAPK cascade +relationship: positively_regulates GO:0000196 ! cell wall integrity MAPK cascade + +[Term] +id: GO:1903140 +name: regulation of establishment of endothelial barrier +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] +is_a: GO:1901550 ! regulation of endothelial cell development +relationship: regulates GO:0061028 ! establishment of endothelial barrier + +[Term] +id: GO:1903141 +name: negative regulation of establishment of endothelial barrier +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] +synonym: "down regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of endothelial barrier" NARROW [GOC:TermGenie] +is_a: GO:1901551 ! negative regulation of endothelial cell development +is_a: GO:1903140 ! regulation of establishment of endothelial barrier +relationship: negatively_regulates GO:0061028 ! establishment of endothelial barrier + +[Term] +id: GO:1903142 +name: positive regulation of establishment of endothelial barrier +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274] +synonym: "activation of establishment of endothelial barrier" NARROW [GOC:TermGenie] +synonym: "up regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of endothelial barrier" EXACT [GOC:TermGenie] +is_a: GO:1901552 ! positive regulation of endothelial cell development +is_a: GO:1903140 ! regulation of establishment of endothelial barrier +relationship: positively_regulates GO:0061028 ! establishment of endothelial barrier + +[Term] +id: GO:1903143 +name: adrenomedullin receptor complex +namespace: cellular_component +def: "A transmembrane, G protein-coupled signalling receptor complex which is capable of adrenomedullin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22102369] +comment: An example of this is RAMP2 in human (O60895) in PMID:22102369 (inferred from direct assay). +synonym: "adrenomedullin receptor AM1 complex" NARROW [] +synonym: "adrenomedullin receptor AM2 complex" NARROW [] +is_a: GO:0038037 ! G protein-coupled receptor dimeric complex +is_a: GO:1903439 ! calcitonin family receptor complex + +[Term] +id: GO:1903144 +name: actomyosin contractile ring actin filament +namespace: cellular_component +def: "Any actin filament that is part of a actomyosin contractile ring." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052] +synonym: "actin filament of actomyosin contractile ring" EXACT [GOC:TermGenie] +synonym: "actin filament of actomyosin ring" EXACT [GOC:TermGenie] +synonym: "actin filament of CAR" EXACT [GOC:TermGenie] +synonym: "actin filament of contractile actomyosin ring" EXACT [GOC:TermGenie] +synonym: "actin filament of cytokinetic ring" EXACT [GOC:TermGenie] +is_a: GO:0005884 ! actin filament +relationship: part_of GO:0005826 ! actomyosin contractile ring + +[Term] +id: GO:1903145 +name: actin filament of cell cortex of cell tip +namespace: cellular_component +def: "Any actin filament that is part of a cell cortex of cell tip." [GO_REF:0000064, GOC:TermGenie, PMID:20807799, PMID:24954052] +synonym: "actin filament of cell cortex of cell end" EXACT [GOC:TermGenie] +synonym: "microfilament of cell cortex of cell end" EXACT [GOC:TermGenie] +synonym: "microfilament of cell cortex of cell tip" EXACT [GOC:TermGenie] +is_a: GO:0005884 ! actin filament +relationship: part_of GO:0051285 ! cell cortex of cell tip + +[Term] +id: GO:1903146 +name: regulation of autophagy of mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrion degradation by an autophagic process." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] +synonym: "regulation of mitochondrion degradation" BROAD [GOC:TermGenie] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0010821 ! regulation of mitochondrion organization +relationship: regulates GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:1903147 +name: negative regulation of autophagy of mitochondrion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24600391] +synonym: "down regulation of mitochondrial degradation" BROAD [GOC:TermGenie] +synonym: "down regulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "down-regulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "down-regulation of mitophagy" BROAD [GOC:TermGenie] +synonym: "downregulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "inhibition of mitochondrion degradation" RELATED [GOC:TermGenie] +synonym: "inhibition of mitophagy" NARROW [GOC:TermGenie] +is_a: GO:0010507 ! negative regulation of autophagy +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:1903146 ! regulation of autophagy of mitochondrion +relationship: negatively_regulates GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:1903148 +name: obsolete uracil transmembrane transporter activity involved in uracil import into cell +namespace: molecular_function +def: "OBSOLETE. Any uracil transmembrane transporter activity that is involved in uracil import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "uracil transmembrane transporter activity involved in uracil import into cell" EXACT [] +synonym: "uracil/uridine permease activity involved in uracil import into cell" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903149 +name: obsolete adenine transmembrane transporter activity involved in adenine import into cell +namespace: molecular_function +def: "OBSOLETE. Any adenine transmembrane transporter activity that is involved in adenine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "adenine transmembrane transporter activity involved in adenine import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903150 +name: obsolete calcium ion transmembrane transporter activity involved in calcium ion import into cell +namespace: molecular_function +def: "OBSOLETE. Any calcium ion transmembrane transporter activity that is involved in calcium ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "calcium ion transmembrane transporter activity involved in calcium ion import into cell" EXACT [] +synonym: "calcium ion transmembrane transporter activity involved in calcium ion uptake into cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903151 +name: obsolete carbohydrate transmembrane transporter activity involved in carbohydrate import into cell +namespace: molecular_function +def: "OBSOLETE. Any carbohydrate transmembrane transporter activity that is involved in carbohydrate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "carbohydrate transmembrane transporter activity involved in carbohydrate import into cell" EXACT [] +synonym: "sugar transporter involved in carbohydrate import into cell" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903152 +name: obsolete copper ion transmembrane transporter activity involved in copper ion import into cell +namespace: molecular_function +def: "OBSOLETE. Any copper ion transmembrane transporter activity that is involved in copper ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "copper ion transmembrane transporter activity involved in copper cation import into cell" EXACT [GOC:TermGenie] +synonym: "copper ion transmembrane transporter activity involved in copper ion import into cell" EXACT [] +synonym: "intracellular copper ion transporter involved in copper cation import into cell" NARROW [GOC:TermGenie] +synonym: "intracellular copper ion transporter involved in copper ion import into cell" NARROW [GOC:TermGenie] +synonym: "plasma membrane copper transporter involved in copper cation import into cell" NARROW [GOC:TermGenie] +synonym: "plasma membrane copper transporter involved in copper ion import into cell" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903153 +name: obsolete ferrous iron transmembrane transporter activity involved in ferrous iron import into cell +namespace: molecular_function +def: "OBSOLETE. Any ferrous iron transmembrane transporter activity that is involved in ferrous iron import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "ferrous iron transmembrane transporter activity involved in ferrous ion import into cell" EXACT [GOC:TermGenie] +synonym: "ferrous iron transmembrane transporter activity involved in ferrous iron import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903154 +name: obsolete glucose transmembrane transporter activity involved in glucose import into cell +namespace: molecular_function +def: "OBSOLETE. Any glucose transmembrane transporter activity that is involved in glucose import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "galactose/glucose (methylgalactoside) porter activity involved in glucose import into cell" RELATED [GOC:TermGenie] +synonym: "glucose permease activity involved in glucose import into cell" EXACT [GOC:TermGenie] +synonym: "glucose transmembrane transporter activity involved in glucose import into cell" EXACT [] +synonym: "lactose/glucose efflux transporter activity involved in glucose import into cell" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903155 +name: obsolete glutathione transmembrane transporter activity involved in glutathione import into cell +namespace: molecular_function +def: "OBSOLETE. Any glutathione transmembrane transporter activity that is involved in glutathione import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "glutathione transmembrane transporter activity involved in glutathione import into cell" EXACT [] +synonym: "glutathione transmembrane transporter activity involved in glutathione uptake" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903156 +name: obsolete guanine transmembrane transporter activity involved in guanine import into cell +namespace: molecular_function +def: "OBSOLETE. Any guanine transmembrane transporter activity that is involved in guanine import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "guanine transmembrane transporter activity involved in guanine import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903157 +name: obsolete iron ion transmembrane transporter activity involved in iron ion import into cell +namespace: molecular_function +def: "OBSOLETE. Any iron ion transmembrane transporter activity that is involved in iron ion import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "iron ion transmembrane transporter activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "iron ion transmembrane transporter activity involved in iron ion import into cell" EXACT [] +synonym: "iron transporter activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "iron transporter activity involved in iron ion import into cell" EXACT [GOC:TermGenie] +synonym: "multicopper ferroxidase iron transport mediator activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "multicopper ferroxidase iron transport mediator activity involved in iron ion import into cell" RELATED [GOC:TermGenie] +synonym: "transmembrane iron ion permease activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "transmembrane iron ion permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie] +synonym: "transmembrane iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "transmembrane iron permease activity involved in iron ion import into cell" EXACT [GOC:TermGenie] +synonym: "zinc, iron permease activity involved in iron import into cell" RELATED [GOC:TermGenie] +synonym: "zinc, iron permease activity involved in iron ion import into cell" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903158 +name: obsolete L-glutamate transmembrane transporter activity involved in L-glutamate import into cell +namespace: molecular_function +def: "OBSOLETE. Any L-glutamate transmembrane transporter activity that is involved in L-glutamate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "glutamate/aspartate porter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie] +synonym: "glutamate/aspartate:sodium symporter activity involved in L-glutamate import into cell" NARROW [GOC:TermGenie] +synonym: "L-glutamate transmembrane transporter activity involved in L-glutamate import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903159 +name: obsolete malate transmembrane transporter activity involved in malate import into cell +namespace: molecular_function +def: "OBSOLETE. Any malate transmembrane transporter activity that is involved in malate import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in malate import into cell" RELATED [GOC:TermGenie] +synonym: "malate transmembrane transporter activity involved in malate import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903160 +name: obsolete nickel cation transmembrane transporter activity involved in nickel cation import into cell +namespace: molecular_function +def: "OBSOLETE. Any nickel cation transmembrane transporter activity that is involved in nickel cation import into cell." [GO_REF:0000061, GOC:dos, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "nickel cation transmembrane transporter activity involved in nickel cation import into cell" EXACT [] +synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity involved in nickel cation import into cell" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903161 +name: obsolete pantothenate transmembrane transporter activity involved in pantothenate import into cell +namespace: molecular_function +def: "OBSOLETE. Any pantothenate transmembrane transporter activity that is involved in pantothenate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "pantothenate transmembrane transporter activity involved in pantothenate import into cell" EXACT [] +synonym: "vitamin B5 transmembrane transporter activity involved in pantothenate import into cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903162 +name: obsolete serine transmembrane transporter activity involved in serine import into cell +namespace: molecular_function +def: "OBSOLETE. Any serine transmembrane transporter activity that is involved in serine import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "serine transmembrane transporter activity involved in serine import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903163 +name: obsolete sodium ion transmembrane transporter activity involved in sodium ion import into cell +namespace: molecular_function +def: "OBSOLETE. Any sodium ion transmembrane transporter activity that is involved in sodium ion import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "sodium ion transmembrane transporter activity involved in sodium ion import into cell" EXACT [] +synonym: "sodium transporter activity involved in sodium ion import into cell" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903164 +name: obsolete succinate transmembrane transporter activity involved in succinate import into cell +namespace: molecular_function +def: "OBSOLETE. Any succinate transmembrane transporter activity that is involved in succinate import into cell." [GO_REF:0000061, GOC:TermGenie, ISBN:0-8249-3695-6] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity involved in succinate import into cell" RELATED [GOC:TermGenie] +synonym: "succinate transmembrane transporter activity involved in succinate import into cell" EXACT [] +is_obsolete: true + +[Term] +id: GO:1903165 +name: response to polycyclic arene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1903166 +name: cellular response to polycyclic arene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polycyclic arene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:10998501] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1903165 ! response to polycyclic arene + +[Term] +id: GO:1903167 +name: regulation of pyrroline-5-carboxylate reductase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of P5CR activity" EXACT [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1903168 +name: positive regulation of pyrroline-5-carboxylate reductase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23743200] +synonym: "activation of 1-pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-proline oxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-proline-NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-proline:NAD(P)+ 5-oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of P5CR activity" NARROW [GOC:TermGenie] +synonym: "activation of pyrroline-5-carboxylate reductase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of P5CR activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of P5CR activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-proline oxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of P5CR activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-proline oxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of P5CR activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrroline-5-carboxylate reductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1903167 ! regulation of pyrroline-5-carboxylate reductase activity + +[Term] +id: GO:1903169 +name: regulation of calcium ion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] +comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol +synonym: "regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +is_a: GO:0051924 ! regulation of calcium ion transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:1903170 +name: negative regulation of calcium ion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24125847] +comment: human HRC regulates RYR2 and thus regulates transmembrane transport of calcium from SR to cytosol +synonym: "down regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of transmembrane calcium transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "negative regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +is_a: GO:0051926 ! negative regulation of calcium ion transport +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +relationship: negatively_regulates GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:1903171 +name: carbon dioxide homeostasis +namespace: biological_process +def: "Any process involved in the maintenance of an internal steady state of carbon dioxide within an organism or cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594] +is_a: GO:0048878 ! chemical homeostasis + +[Term] +id: GO:1903172 +name: cellular carbon dioxide homeostasis +namespace: biological_process +def: "Any biological process involved in the maintenance of an internal steady state of carbon dioxide at the level of the cell." [GO_REF:0000072, GOC:mr, GOC:TermGenie, PMID:16571594] +is_a: GO:0055082 ! cellular chemical homeostasis +is_a: GO:1903171 ! carbon dioxide homeostasis + +[Term] +id: GO:1903173 +name: fatty alcohol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] +synonym: "fatty alcohol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006066 ! alcohol metabolic process +is_a: GO:0006629 ! lipid metabolic process + +[Term] +id: GO:1903174 +name: fatty alcohol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] +synonym: "fatty alcohol breakdown" EXACT [GOC:TermGenie] +synonym: "fatty alcohol catabolism" EXACT [GOC:TermGenie] +synonym: "fatty alcohol degradation" EXACT [GOC:TermGenie] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0046164 ! alcohol catabolic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:1903175 +name: fatty alcohol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of fatty alcohol." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:24036493] +synonym: "fatty alcohol anabolism" EXACT [GOC:TermGenie] +synonym: "fatty alcohol biosynthesis" EXACT [GOC:TermGenie] +synonym: "fatty alcohol formation" EXACT [GOC:TermGenie] +synonym: "fatty alcohol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0046165 ! alcohol biosynthetic process +is_a: GO:1903173 ! fatty alcohol metabolic process + +[Term] +id: GO:1903176 +name: regulation of tyrosine 3-monooxygenase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0032768 ! regulation of monooxygenase activity + +[Term] +id: GO:1903177 +name: negative regulation of tyrosine 3-monooxygenase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "down regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "downregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0032769 ! negative regulation of monooxygenase activity +is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity + +[Term] +id: GO:1903178 +name: positive regulation of tyrosine 3-monooxygenase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] +synonym: "activation of L-tyrosine hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" NARROW [GOC:TermGenie] +synonym: "activation of tyrosine 3-hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "activation of tyrosine 3-monooxygenase activity" NARROW [GOC:TermGenie] +synonym: "activation of tyrosine hydroxylase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of TH activity" EXACT [PMID:19703902] +synonym: "positive regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "stimulation of TH activity" EXACT [PMID:19703902] +synonym: "up regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "up regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [GOC:TermGenie] +synonym: "upregulation of tyrosine 3-hydroxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tyrosine 3-monooxygenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tyrosine hydroxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0032770 ! positive regulation of monooxygenase activity +is_a: GO:1903176 ! regulation of tyrosine 3-monooxygenase activity + +[Term] +id: GO:1903179 +name: regulation of dopamine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "regulation of dopamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042053 ! regulation of dopamine metabolic process +relationship: regulates GO:0042416 ! dopamine biosynthetic process + +[Term] +id: GO:1903180 +name: negative regulation of dopamine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of dopamine anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine formation" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of dopamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045963 ! negative regulation of dopamine metabolic process +is_a: GO:1903179 ! regulation of dopamine biosynthetic process +relationship: negatively_regulates GO:0042416 ! dopamine biosynthetic process + +[Term] +id: GO:1903181 +name: positive regulation of dopamine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] +synonym: "activation of dopamine anabolism" NARROW [GOC:TermGenie] +synonym: "activation of dopamine biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of dopamine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of dopamine formation" NARROW [GOC:TermGenie] +synonym: "activation of dopamine synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045964 ! positive regulation of dopamine metabolic process +is_a: GO:1903179 ! regulation of dopamine biosynthetic process +relationship: positively_regulates GO:0042416 ! dopamine biosynthetic process + +[Term] +id: GO:1903182 +name: regulation of SUMO transferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] +synonym: "regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] +is_a: GO:0033233 ! regulation of protein sumoylation +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1903183 +name: negative regulation of SUMO transferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528] +synonym: "down regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] +synonym: "down regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] +synonym: "down regulation of SUMO ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] +synonym: "down-regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of SUMO ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] +synonym: "downregulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] +synonym: "downregulation of SUMO ligase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of SMT3 conjugating enzyme" NARROW [GOC:TermGenie] +synonym: "inhibition of SUMO conjugating enzyme activity" NARROW [GOC:TermGenie] +synonym: "inhibition of SUMO ligase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of SMT3 conjugating enzyme" EXACT [GOC:TermGenie] +synonym: "negative regulation of SUMO conjugating enzyme activity" EXACT [GOC:TermGenie] +is_a: GO:0033234 ! negative regulation of protein sumoylation +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1903182 ! regulation of SUMO transferase activity + +[Term] +id: GO:1903184 +name: L-dopa metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146] +synonym: "L-dopa metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:0009072 ! aromatic amino acid family metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1903185 +name: L-dopa biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of L-dopa." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:8822146] +synonym: "L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "L-dopa formation" EXACT [GOC:TermGenie] +synonym: "L-dopa synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009073 ! aromatic amino acid family biosynthetic process +is_a: GO:0042398 ! cellular modified amino acid biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process +is_a: GO:1903184 ! L-dopa metabolic process + +[Term] +id: GO:1903186 +name: regulation of vitellogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] +synonym: "regulation of yolk production" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007296 ! vitellogenesis + +[Term] +id: GO:1903187 +name: negative regulation of vitellogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] +synonym: "down regulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of yolk production" EXACT [GOC:TermGenie] +synonym: "down-regulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of yolk production" EXACT [GOC:TermGenie] +synonym: "downregulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of yolk production" EXACT [GOC:TermGenie] +synonym: "inhibition of vitellogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of yolk production" NARROW [GOC:TermGenie] +synonym: "negative regulation of yolk production" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903186 ! regulation of vitellogenesis +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007296 ! vitellogenesis + +[Term] +id: GO:1903188 +name: positive regulation of vitellogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vitellogenesis." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19467235] +synonym: "activation of vitellogenesis" NARROW [GOC:TermGenie] +synonym: "activation of yolk production" NARROW [GOC:TermGenie] +synonym: "positive regulation of yolk production" EXACT [GOC:TermGenie] +synonym: "up regulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of yolk production" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of yolk production" EXACT [GOC:TermGenie] +synonym: "upregulation of vitellogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of yolk production" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903186 ! regulation of vitellogenesis +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0007296 ! vitellogenesis + +[Term] +id: GO:1903189 +name: glyoxal metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "glyoxal metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006081 ! cellular aldehyde metabolic process + +[Term] +id: GO:1903190 +name: glyoxal catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22523093, PMID:23651081] +synonym: "glyoxal breakdown" EXACT [GOC:TermGenie] +synonym: "glyoxal catabolism" EXACT [GOC:TermGenie] +synonym: "glyoxal degradation" EXACT [GOC:TermGenie] +is_a: GO:0046185 ! aldehyde catabolic process +is_a: GO:1903189 ! glyoxal metabolic process + +[Term] +id: GO:1903191 +name: glyoxal biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of glyoxal." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "glyoxal anabolism" EXACT [GOC:TermGenie] +synonym: "glyoxal biosynthesis" EXACT [GOC:TermGenie] +synonym: "glyoxal formation" EXACT [GOC:TermGenie] +synonym: "glyoxal synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046184 ! aldehyde biosynthetic process +is_a: GO:1903189 ! glyoxal metabolic process + +[Term] +id: GO:1903192 +name: sesquarterpene metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333] +synonym: "sesquarterpene metabolism" EXACT [GOC:TermGenie] +is_a: GO:0042214 ! terpene metabolic process + +[Term] +id: GO:1903193 +name: sesquarterpene biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of sesquarterpene." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:21627333] +synonym: "sesquarterpene anabolism" EXACT [GOC:TermGenie] +synonym: "sesquarterpene biosynthesis" EXACT [GOC:TermGenie] +synonym: "sesquarterpene formation" EXACT [GOC:TermGenie] +synonym: "sesquarterpene synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046246 ! terpene biosynthetic process +is_a: GO:1903192 ! sesquarterpene metabolic process + +[Term] +id: GO:1903195 +name: regulation of L-dopa biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:1903185 ! L-dopa biosynthetic process + +[Term] +id: GO:1903196 +name: negative regulation of L-dopa biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "down regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of L-dopa anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of L-dopa biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of L-dopa biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of L-dopa formation" NARROW [GOC:TermGenie] +synonym: "inhibition of L-dopa synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +is_a: GO:1903195 ! regulation of L-dopa biosynthetic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:1903185 ! L-dopa biosynthetic process + +[Term] +id: GO:1903197 +name: positive regulation of L-dopa biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-dopa biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16731528] +synonym: "activation of L-dopa anabolism" NARROW [GOC:TermGenie] +synonym: "activation of L-dopa biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of L-dopa biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of L-dopa formation" NARROW [GOC:TermGenie] +synonym: "activation of L-dopa synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa formation" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa synthesis" EXACT [GOC:TermGenie] +is_a: GO:1903195 ! regulation of L-dopa biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:1903185 ! L-dopa biosynthetic process + +[Term] +id: GO:1903198 +name: regulation of L-dopa decarboxylase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:1903199 +name: negative regulation of L-dopa decarboxylase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DDC activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DOPA decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of L-dopa decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051350 ! negative regulation of lyase activity +is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity + +[Term] +id: GO:1903200 +name: positive regulation of L-dopa decarboxylase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19703902] +synonym: "activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "activation of DDC activity" NARROW [GOC:TermGenie] +synonym: "activation of DOPA decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-dopa decarboxylase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DDC activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DOPA decarboxylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-dopa decarboxylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051349 ! positive regulation of lyase activity +is_a: GO:1903198 ! regulation of L-dopa decarboxylase activity + +[Term] +id: GO:1903201 +name: regulation of oxidative stress-induced cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of cell death in response to oxidative stress" EXACT [GOC:bf] +is_a: GO:0010941 ! regulation of cell death +is_a: GO:1900407 ! regulation of cellular response to oxidative stress +relationship: regulates GO:0036473 ! cell death in response to oxidative stress + +[Term] +id: GO:1903202 +name: negative regulation of oxidative stress-induced cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "down regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cell death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell death in response to oxidative stress" EXACT [GOC:bf] +synonym: "protection against oxidative stress-induced cell death" RELATED [GOC:bf] +is_a: GO:0060548 ! negative regulation of cell death +is_a: GO:1903201 ! regulation of oxidative stress-induced cell death +relationship: negatively_regulates GO:0036473 ! cell death in response to oxidative stress + +[Term] +id: GO:1903203 +name: regulation of oxidative stress-induced neuron death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of neuron death in response to oxidative stress" EXACT [GOC:bf] +synonym: "regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:1901214 ! regulation of neuron death +is_a: GO:1903201 ! regulation of oxidative stress-induced cell death +relationship: regulates GO:0036475 ! neuron death in response to oxidative stress + +[Term] +id: GO:1903204 +name: negative regulation of oxidative stress-induced neuron death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "down regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +synonym: "inhibition of neuron death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "inhibition of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "inhibition of oxidative stress-induced neuron death" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "neuronal protection under oxidative stress" RELATED [GOC:bf] +synonym: "neuroprotection against oxidative stress" RELATED [GOC:bf] +is_a: GO:1901215 ! negative regulation of neuron death +is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death +is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death +relationship: negatively_regulates GO:0036475 ! neuron death in response to oxidative stress + +[Term] +id: GO:1903205 +name: regulation of hydrogen peroxide-induced cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "protection against hydrogen peroxide-mediated cell death" RELATED [GOC:bf] +synonym: "regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf] +synonym: "regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +is_a: GO:1901031 ! regulation of response to reactive oxygen species +is_a: GO:1903201 ! regulation of oxidative stress-induced cell death +relationship: regulates GO:0036474 ! cell death in response to hydrogen peroxide + +[Term] +id: GO:1903206 +name: negative regulation of hydrogen peroxide-induced cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14749723, PMID:24252804] +synonym: "down regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "downregulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "downregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "inhibition of cell death in response to H2O2" NARROW [GOC:TermGenie] +synonym: "inhibition of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "negative regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell death in response to hydrogen peroxide" EXACT [GOC:bf] +synonym: "negative regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "protection against H2O2-induced cell death" RELATED [GOC:bf] +synonym: "protection against hydrogen peroxide-induced cell death" RELATED [GOC:bf] +is_a: GO:1901032 ! negative regulation of response to reactive oxygen species +is_a: GO:1903202 ! negative regulation of oxidative stress-induced cell death +is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death +relationship: negatively_regulates GO:0036474 ! cell death in response to hydrogen peroxide + +[Term] +id: GO:1903207 +name: regulation of hydrogen peroxide-induced neuron death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf] +synonym: "regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death +is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death +relationship: regulates GO:0036476 ! neuron death in response to hydrogen peroxide + +[Term] +id: GO:1903208 +name: negative regulation of hydrogen peroxide-induced neuron death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "down regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen peroxide-induced neuron death" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "downregulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "inhibition of hydrogen peroxide-induced neuron death" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron death in response to H2O2" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron death in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "inhibition of neuronal cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuron death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuron death in response to hydrogen peroxide" EXACT [GOC:bf] +synonym: "negative regulation of neuronal cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "neuroprotection against H2O2-induced cell death" RELATED [GOC:bf] +synonym: "neuroprotection against hydrogen peroxide" RELATED [GOC:bf] +synonym: "protection against H2O2-induced neuron death" RELATED [GOC:bf] +synonym: "protection against hydrogen peroxide-induced neuron death" RELATED [GOC:bf] +is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death +is_a: GO:1903206 ! negative regulation of hydrogen peroxide-induced cell death +is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death +relationship: negatively_regulates GO:0036476 ! neuron death in response to hydrogen peroxide + +[Term] +id: GO:1903209 +name: positive regulation of oxidative stress-induced cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced cell death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20969476] +synonym: "activation of cell death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "enhancement of oxidative stress-induced cell death" NARROW [] +synonym: "positive regulation of cell death in response to oxidative stress" EXACT [] +synonym: "up regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of cell death in response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:0010942 ! positive regulation of cell death +is_a: GO:1903201 ! regulation of oxidative stress-induced cell death +relationship: positively_regulates GO:0036473 ! cell death in response to oxidative stress + +[Term] +id: GO:1903210 +name: glomerular visceral epithelial cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a glomerular visceral epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:23515840] +synonym: "glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "podocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1903211 +name: mitotic recombination involved in replication fork processing +namespace: biological_process +def: "Any mitotic recombination that is involved in replication fork processing." [GO_REF:0000060, GOC:mah, GOC:TermGenie, PMID:23093942] +synonym: "mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie] +synonym: "mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie] +synonym: "mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie] +synonym: "mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie] +synonym: "mitotic recombination involved in replication restart" RELATED [GOC:TermGenie] +is_a: GO:0006312 ! mitotic recombination +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1990426 ! mitotic recombination-dependent replication fork processing + +[Term] +id: GO:1903212 +name: protein localization to mating-type region heterochromatin +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:18761674] +synonym: "protein localisation in mating-type region heterochromatin" EXACT [GOC:TermGenie] +synonym: "protein localisation to mating-type region heterochromatin" EXACT [GOC:TermGenie] +synonym: "protein localization in mating-type region heterochromatin" EXACT [GOC:TermGenie] +is_a: GO:0097355 ! protein localization to heterochromatin + +[Term] +id: GO:1903213 +name: protein localization to subtelomeric heterochromatin +namespace: biological_process +alt_id: GO:1990152 +def: "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:21300781, SO:0001997] +synonym: "protein localisation in subtelomeric heterochromatin" EXACT [GOC:TermGenie] +synonym: "protein localisation to subtelomeric heterochromatin" EXACT [GOC:TermGenie] +synonym: "protein localisation to telomeric heterochromatin" RELATED [GOC:mah] +synonym: "protein localization in subtelomeric heterochromatin" EXACT [GOC:TermGenie] +synonym: "protein localization to telomeric heterochromatin" RELATED [] +is_a: GO:0070198 ! protein localization to chromosome, telomeric region +is_a: GO:0097355 ! protein localization to heterochromatin + +[Term] +id: GO:1903214 +name: regulation of protein targeting to mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +is_a: GO:1903533 ! regulation of protein targeting +is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion +relationship: regulates GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:1903215 +name: negative regulation of protein targeting to mitochondrion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] +synonym: "down regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "down regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "down regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "down regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "down regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "down-regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "downregulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "downregulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "downregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "inhibition of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "inhibition of protein import into mitochondrion" NARROW [GOC:TermGenie] +synonym: "inhibition of protein targeting to mitochondria" NARROW [GOC:TermGenie] +synonym: "inhibition of protein targeting to mitochondrion" NARROW [GOC:TermGenie] +synonym: "inhibition of protein-mitochondrial targeting" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1903214 ! regulation of protein targeting to mitochondrion +is_a: GO:1903748 ! negative regulation of establishment of protein localization to mitochondrion +relationship: negatively_regulates GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:1903216 +name: regulation of protein processing involved in protein targeting to mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] +synonym: "regulation of mitochondrial processing" BROAD [GOC:TermGenie] +synonym: "regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0070613 ! regulation of protein processing +relationship: regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion + +[Term] +id: GO:1903217 +name: negative regulation of protein processing involved in protein targeting to mitochondrion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing involved in protein targeting to mitochondrion." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21370995] +synonym: "down regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +synonym: "down regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +synonym: "downregulation of protein processing involved in protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +synonym: "inhibition of protein processing involved in protein targeting to mitochondrion" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial protein processing during import" RELATED [GOC:TermGenie] +is_a: GO:0010955 ! negative regulation of protein processing +is_a: GO:1903216 ! regulation of protein processing involved in protein targeting to mitochondrion +relationship: negatively_regulates GO:0006627 ! protein processing involved in protein targeting to mitochondrion + +[Term] +id: GO:1903218 +name: regulation of malate dehydrogenase (decarboxylating) (NADP+) activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] +synonym: "regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1903219 +name: negative regulation of malate dehydrogenase (decarboxylating) (NADP+) activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] +synonym: "down regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "down regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "down regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "down regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "down regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "down regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "down-regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "down-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "down-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "down-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "downregulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "downregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "downregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "downregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "downregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "downregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "inhibition of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "inhibition of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie] +synonym: "inhibition of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie] +synonym: "inhibition of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie] +synonym: "inhibition of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "inhibition of NADP-malic enzyme activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "negative regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "negative regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "negative regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "negative regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity + +[Term] +id: GO:1903220 +name: positive regulation of malate dehydrogenase (decarboxylating) (NADP+) activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of malate dehydrogenase (decarboxylating) (NADP+) activity." [GO_REF:0000059, GOC:sart, GOC:TermGenie, PMID:12398416] +synonym: "activation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "activation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" NARROW [GOC:TermGenie] +synonym: "activation of L-malate:NADP oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of malate dehydrogenase (decarboxylating) (NADP+) activity" NARROW [GOC:TermGenie] +synonym: "activation of malate dehydrogenase (decarboxylating, NADP)" NARROW [GOC:TermGenie] +synonym: "activation of malate dehydrogenase (NADP, decarboxylating)" NARROW [GOC:TermGenie] +synonym: "activation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "activation of NADP-malic enzyme activity" NARROW [GOC:TermGenie] +synonym: "activation of NADP-specific malate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "positive regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "up regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "up regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "up regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "up regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "up regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "up regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "up-regulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +synonym: "upregulation of 'malic' enzyme" RELATED [GOC:TermGenie] +synonym: "upregulation of (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [GOC:TermGenie] +synonym: "upregulation of L-malate:NADP oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of malate dehydrogenase (decarboxylating) (NADP+) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of malate dehydrogenase (decarboxylating, NADP)" EXACT [GOC:TermGenie] +synonym: "upregulation of malate dehydrogenase (NADP, decarboxylating)" EXACT [GOC:TermGenie] +synonym: "upregulation of NADP-linked decarboxylating malic enzyme" RELATED [GOC:TermGenie] +synonym: "upregulation of NADP-malic enzyme activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NADP-specific malate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NADP-specific malic enzyme" RELATED [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1903218 ! regulation of malate dehydrogenase (decarboxylating) (NADP+) activity + +[Term] +id: GO:1903221 +name: regulation of mitotic recombination involved in replication fork processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic recombination involved in replication fork processing. Regulation of mitotic recombination contributes to replication fork processing by preventing recombination between inappropriate homologous sequences." [GO_REF:0000058, GOC:TermGenie, PMID:23093942] +synonym: "prevention of genomic instability induced by DNA replication fork arrest" RELATED [PMID:23093942] +synonym: "regulation of mitotic recombination involved in collapsed replication fork processing" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic recombination involved in recovery from replication fork arrest" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic recombination involved in recovery from replication fork stalling" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic recombination involved in replication fork restart" RELATED [GOC:TermGenie] +synonym: "regulation of mitotic recombination involved in replication restart" RELATED [GOC:TermGenie] +is_a: GO:0000019 ! regulation of mitotic recombination +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:1903211 ! mitotic recombination involved in replication fork processing + +[Term] +id: GO:1903222 +name: quinolinic acid transmembrane transport +namespace: biological_process +def: "The process in which quinolinic acid is transported across a membrane." [GO_REF:0000069, GOC:di, GOC:TermGenie, PMID:23457190] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0071705 ! nitrogen compound transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1903223 +name: positive regulation of oxidative stress-induced neuron death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron death." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23858059] +synonym: "activation of neuron death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "activation of neuronal cell death in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "activation of oxidative stress-induced neuron death" NARROW [GOC:TermGenie] +synonym: "positive regulation of neuron death in response to oxidative stress" EXACT [GOC:bf] +synonym: "positive regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "sensitization of neuron to oxidative stress-induced cell death" RELATED [PMID:23858059] +synonym: "up regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +synonym: "upregulation of neuron death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of neuronal cell death in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidative stress-induced neuron death" EXACT [GOC:TermGenie] +is_a: GO:1901216 ! positive regulation of neuron death +is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death +is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death +relationship: positively_regulates GO:0036475 ! neuron death in response to oxidative stress + +[Term] +id: GO:1903224 +name: regulation of endodermal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] +synonym: "regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0035987 ! endodermal cell differentiation + +[Term] +id: GO:1903225 +name: negative regulation of endodermal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] +synonym: "down regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of endoderm cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of endodermal cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1903224 ! regulation of endodermal cell differentiation +relationship: negatively_regulates GO:0035987 ! endodermal cell differentiation + +[Term] +id: GO:1903226 +name: positive regulation of endodermal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23154389] +synonym: "activation of endoderm cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of endodermal cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of endoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of endodermal cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1903224 ! regulation of endodermal cell differentiation +relationship: positively_regulates GO:0035987 ! endodermal cell differentiation + +[Term] +id: GO:1903227 +name: xanthosine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] +synonym: "xanthosine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046128 ! purine ribonucleoside metabolic process + +[Term] +id: GO:1903228 +name: xanthosine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] +synonym: "xanthosine breakdown" EXACT [GOC:TermGenie] +synonym: "xanthosine catabolism" EXACT [GOC:TermGenie] +synonym: "xanthosine degradation" EXACT [GOC:TermGenie] +is_a: GO:0046130 ! purine ribonucleoside catabolic process +is_a: GO:1903227 ! xanthosine metabolic process + +[Term] +id: GO:1903229 +name: xanthosine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of xanthosine." [GO_REF:0000068, GOC:TermGenie, PMID:7007809, PMID:7559336] +synonym: "xanthosine anabolism" EXACT [GOC:TermGenie] +synonym: "xanthosine biosynthesis" EXACT [GOC:TermGenie] +synonym: "xanthosine formation" EXACT [GOC:TermGenie] +synonym: "xanthosine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046129 ! purine ribonucleoside biosynthetic process +is_a: GO:1903227 ! xanthosine metabolic process + +[Term] +id: GO:1903230 +name: obsolete miRNA binding involved in posttranscriptional gene silencing +namespace: molecular_function +def: "OBSOLETE. Any miRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:jl, GOC:TermGenie] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "microRNA binding involved in cosuppression" RELATED [GOC:TermGenie] +synonym: "microRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] +synonym: "microRNA binding involved in posttranscriptional gene silencing" EXACT [GOC:TermGenie] +synonym: "microRNA binding involved in PTGS" EXACT [GOC:TermGenie] +synonym: "microRNA binding involved in quelling" EXACT [GOC:TermGenie] +synonym: "miRNA binding involved in cosuppression" RELATED [GOC:TermGenie] +synonym: "miRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] +synonym: "miRNA binding involved in posttranscriptional gene silencing" EXACT [] +synonym: "miRNA binding involved in PTGS" EXACT [GOC:TermGenie] +synonym: "miRNA binding involved in quelling" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903231 +name: mRNA binding involved in posttranscriptional gene silencing +namespace: molecular_function +def: "Any mRNA binding that is involved in posttranscriptional gene silencing." [GO_REF:0000061, GOC:BHF, GOC:BHF_miRNA, GOC:jl, GOC:TermGenie] +synonym: "mRNA binding involved in cosuppression" RELATED [GOC:TermGenie] +synonym: "mRNA binding involved in post-transcriptional gene silencing" EXACT [GOC:TermGenie] +synonym: "mRNA binding involved in PTGS" EXACT [GOC:TermGenie] +synonym: "mRNA binding involved in quelling" EXACT [GOC:TermGenie] +is_a: GO:0003729 ! mRNA binding +is_a: GO:0150100 ! RNA binding involved in posttranscriptional gene silencing + +[Term] +id: GO:1903232 +name: melanosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22511774] +synonym: "melanosome formation" EXACT [GOC:TermGenie] +is_a: GO:0032438 ! melanosome organization +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:1903233 +name: regulation of calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis +relationship: regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter + +[Term] +id: GO:1903234 +name: negative regulation of calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) +synonym: "down regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] +is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis +is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter +is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis +relationship: negatively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter + +[Term] +id: GO:1903235 +name: positive regulation of calcium ion-dependent exocytosis of neurotransmitter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis of neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 (IMP) +synonym: "activation of calcium ion-dependent exocytosis of neurotransmitter" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion-dependent exocytosis of neurotransmitter" EXACT [GOC:TermGenie] +is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis +is_a: GO:1903233 ! regulation of calcium ion-dependent exocytosis of neurotransmitter +is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis +relationship: positively_regulates GO:0048791 ! calcium ion-regulated exocytosis of neurotransmitter + +[Term] +id: GO:1903236 +name: regulation of leukocyte tethering or rolling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] +is_a: GO:0002691 ! regulation of cellular extravasation +is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell +relationship: regulates GO:0050901 ! leukocyte tethering or rolling + +[Term] +id: GO:1903237 +name: negative regulation of leukocyte tethering or rolling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] +synonym: "down regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +synonym: "inhibition of leukocyte tethering or rolling" NARROW [GOC:TermGenie] +is_a: GO:0002692 ! negative regulation of cellular extravasation +is_a: GO:1903236 ! regulation of leukocyte tethering or rolling +is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell +relationship: negatively_regulates GO:0050901 ! leukocyte tethering or rolling + +[Term] +id: GO:1903238 +name: positive regulation of leukocyte tethering or rolling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18308860] +synonym: "activation of leukocyte tethering or rolling" NARROW [GOC:TermGenie] +synonym: "up regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte tethering or rolling" EXACT [GOC:TermGenie] +is_a: GO:1903236 ! regulation of leukocyte tethering or rolling +is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell +relationship: positively_regulates GO:0050901 ! leukocyte tethering or rolling + +[Term] +id: GO:1903239 +name: obsolete regulation of positive regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [] +synonym: "regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903240 +name: obsolete negative regulation of positive regulation of the force of heart contraction by chemical signal +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of positive regulation of the force of heart contraction by chemical signal." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17242280] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "down regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "down-regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "downregulation of positive regulation of the force of heart contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "downregulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] +synonym: "inhibition of positive regulation of the force of heart contraction by chemical signal" NARROW [GOC:TermGenie] +synonym: "inhibition of positive regulation of the force of heart muscle contraction by chemical signal" NARROW [GOC:TermGenie] +synonym: "negative regulation of positive regulation of the force of heart contraction by chemical signal" EXACT [] +synonym: "negative regulation of positive regulation of the force of heart muscle contraction by chemical signal" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903241 +name: U2-type prespliceosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752] +synonym: "GT-AG prespliceosome assembly" NARROW [GOC:TermGenie] +synonym: "GT-AG prespliceosome formation" NARROW [GOC:TermGenie] +synonym: "major prespliceosome assembly" EXACT [GOC:TermGenie] +synonym: "major prespliceosome formation" EXACT [GOC:TermGenie] +synonym: "mammalian U2-type spliceosomal complex A assembly" NARROW [GOC:TermGenie] +synonym: "mammalian U2-type spliceosomal complex A formation" NARROW [GOC:TermGenie] +synonym: "U2-type prespliceosome formation" EXACT [GOC:TermGenie] +synonym: "yeast U2-type spliceosomal complex B assembly" NARROW [GOC:TermGenie] +synonym: "yeast U2-type spliceosomal complex B formation" NARROW [GOC:TermGenie] +is_a: GO:0000245 ! spliceosomal complex assembly + +[Term] +id: GO:1903242 +name: regulation of cardiac muscle hypertrophy in response to stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] +is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy +is_a: GO:0010612 ! regulation of cardiac muscle adaptation +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress + +[Term] +id: GO:1903243 +name: negative regulation of cardiac muscle hypertrophy in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] +synonym: "down regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie] +is_a: GO:0010614 ! negative regulation of cardiac muscle hypertrophy +is_a: GO:0010616 ! negative regulation of cardiac muscle adaptation +is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress +relationship: negatively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress + +[Term] +id: GO:1903244 +name: positive regulation of cardiac muscle hypertrophy in response to stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093] +synonym: "activation of cardiac muscle hypertrophy in response to stress" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac muscle hypertrophy in response to stress" EXACT [GOC:TermGenie] +is_a: GO:0010613 ! positive regulation of cardiac muscle hypertrophy +is_a: GO:0010615 ! positive regulation of cardiac muscle adaptation +is_a: GO:1903242 ! regulation of cardiac muscle hypertrophy in response to stress +relationship: positively_regulates GO:0014898 ! cardiac muscle hypertrophy in response to stress + +[Term] +id: GO:1903245 +name: obsolete regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903246 +name: obsolete negative regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "down regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "down regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "down-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "down-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "downregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "downregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "downregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "downregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "inhibition of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "inhibition of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "inhibition of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "inhibition of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "negative regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "negative regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903247 +name: obsolete positive regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of adrenergic receptor signaling pathway involved in positive regulation of heart rate." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:17242280] +comment: This term was obsoleted because it is not precise enough. We must specify if the ACA-activating or ACA inhibiting pathway is the target of the regulation. +synonym: "activation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "activation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "activation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "activation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "activation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "positive regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "positive regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "up regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up-regulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "up-regulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "up-regulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of activation of funny current by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of adenylate cyclase-activating cardiac adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "upregulation of adrenergic receptor signalling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "upregulation of beta adrenergic receptor signaling pathway involved in positive regulation of heart rate" NARROW [GOC:TermGenie] +synonym: "upregulation of Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate" EXACT [GOC:TermGenie] +synonym: "upregulation of If activation by beta-adrenergic receptor signaling pathway" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903248 +name: regulation of citrulline biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] +synonym: "regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "regulation of citrulline synthesis" EXACT [GOC:TermGenie] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0019240 ! citrulline biosynthetic process + +[Term] +id: GO:1903249 +name: negative regulation of citrulline biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] +synonym: "down regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "down regulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "downregulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of citrulline anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of citrulline biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of citrulline biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of citrulline formation" NARROW [GOC:TermGenie] +synonym: "inhibition of citrulline synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of citrulline synthesis" EXACT [GOC:TermGenie] +is_a: GO:1903248 ! regulation of citrulline biosynthetic process +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0019240 ! citrulline biosynthetic process + +[Term] +id: GO:1903250 +name: positive regulation of citrulline biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of citrulline biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19278978] +synonym: "activation of citrulline anabolism" NARROW [GOC:TermGenie] +synonym: "activation of citrulline biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of citrulline biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of citrulline formation" NARROW [GOC:TermGenie] +synonym: "activation of citrulline synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline formation" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline synthesis" EXACT [GOC:TermGenie] +is_a: GO:1903248 ! regulation of citrulline biosynthetic process +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:0019240 ! citrulline biosynthetic process + +[Term] +id: GO:1903251 +name: multi-ciliated epithelial cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a multi-ciliated epithelial cell." [GO_REF:0000086, GOC:sp, GOC:TermGenie, PMID:22231168, PMID:24934224] +synonym: "multiciliate cell differentiation" BROAD [] +is_a: GO:0030855 ! epithelial cell differentiation + +[Term] +id: GO:1903252 +name: hercynylcysteine sulfoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "hercynylcysteine sulfoxide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:1903253 +name: hercynylcysteine sulfoxide biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hercynylcysteine sulfoxide." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "hercynylcysteine sulfoxide anabolism" EXACT [GOC:TermGenie] +synonym: "hercynylcysteine sulfoxide biosynthesis" EXACT [GOC:TermGenie] +synonym: "hercynylcysteine sulfoxide formation" EXACT [GOC:TermGenie] +synonym: "hercynylcysteine sulfoxide synthesis" EXACT [GOC:TermGenie] +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:0052703 ! cellular modified histidine biosynthetic process +is_a: GO:1903252 ! hercynylcysteine sulfoxide metabolic process + +[Term] +id: GO:1903254 +name: hercynylselenocysteine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "hercynylselenocysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0001887 ! selenium compound metabolic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:1903255 +name: hercynylselenocysteine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of hercynylselenocysteine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "hercynylselenocysteine anabolism" EXACT [GOC:TermGenie] +synonym: "hercynylselenocysteine biosynthesis" EXACT [GOC:TermGenie] +synonym: "hercynylselenocysteine formation" EXACT [GOC:TermGenie] +synonym: "hercynylselenocysteine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0052703 ! cellular modified histidine biosynthetic process +is_a: GO:1903254 ! hercynylselenocysteine metabolic process + +[Term] +id: GO:1903256 +name: selenoneine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "L-selenoneine metabolic process" NARROW [] +synonym: "selenoneine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006577 ! amino-acid betaine metabolic process +is_a: GO:0052701 ! cellular modified histidine metabolic process + +[Term] +id: GO:1903257 +name: selenoneine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of selenoneine." [GO_REF:0000068, GOC:TermGenie, PMID:24828577] +synonym: "L-selenoneine biosynthetic process" NARROW [] +synonym: "selenoneine anabolism" EXACT [GOC:TermGenie] +synonym: "selenoneine biosynthesis" EXACT [GOC:TermGenie] +synonym: "selenoneine formation" EXACT [GOC:TermGenie] +synonym: "selenoneine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006578 ! amino-acid betaine biosynthetic process +is_a: GO:0052703 ! cellular modified histidine biosynthetic process +is_a: GO:1903256 ! selenoneine metabolic process + +[Term] +id: GO:1903258 +name: sorbose import across plasma membrane +namespace: biological_process +def: "The process in which sorbose is transported from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:2878925] +synonym: "sorbose import into cell" EXACT [] +is_a: GO:0140271 ! hexose import across plasma membrane + +[Term] +id: GO:1903259 +name: exon-exon junction complex disassembly +namespace: biological_process +def: "The disaggregation of an exon-exon junction complex into its constituent components." [GO_REF:0000079, GOC:sart, GOC:TermGenie, PMID:24967911] +synonym: "EJC disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:1903260 +name: protein localization to mating projection tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a mating projection tip." [GO_REF:0000087, GOC:TermGenie, PMID:11952834] +synonym: "protein localisation in mating projection tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to mating projection tip" EXACT [GOC:TermGenie] +synonym: "protein localization in mating projection tip" EXACT [GOC:TermGenie] +synonym: "protein localization to conjugation tube tip" NARROW [] +synonym: "protein localization to shmoo tip" NARROW [] +is_a: GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1903264 +name: nitrate reductase activity involved in anaerobic electron transport chain +namespace: molecular_function +def: "Any nitrate reductase activity that is involved in anaerobic electron transport chain." [GO_REF:0000061, GOC:dos, GOC:TermGenie, PMID:12910261] +synonym: "nitrate reductase (acceptor) involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] +synonym: "nitrite:(acceptor) oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] +synonym: "nitrite:acceptor oxidoreductase involved in anaerobic electron transport chain" EXACT [GOC:TermGenie] +synonym: "respiratory nitrate reductase activity involved in anaerobic electron transport chain" NARROW [GOC:TermGenie] +is_a: GO:0008940 ! nitrate reductase activity +is_a: GO:0009055 ! electron transfer activity + +[Term] +id: GO:1903265 +name: positive regulation of tumor necrosis factor-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor-mediated signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807] +synonym: "activation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of tumor necrosis factor-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of tumor necrosis factor-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "up-regulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of adipocytokine signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of TNF-alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of tumor necrosis factor alpha-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "upregulation of tumor necrosis factor-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway +relationship: positively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway + +[Term] +id: GO:1903266 +name: regulation of ornithine catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] +comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). +synonym: "regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ornithine degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0090368 ! regulation of ornithine metabolic process +relationship: regulates GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:1903267 +name: negative regulation of ornithine catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] +comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). +synonym: "down regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of ornithine breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of ornithine catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ornithine catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ornithine degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ornithine degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1903266 ! regulation of ornithine catabolic process +relationship: negatively_regulates GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:1903268 +name: positive regulation of ornithine catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ornithine catabolic process." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:12679340] +synonym: "activation of ornithine breakdown" NARROW [GOC:TermGenie] +synonym: "activation of ornithine catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ornithine catabolism" NARROW [GOC:TermGenie] +synonym: "activation of ornithine degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ornithine degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of ornithine breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of ornithine catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ornithine catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ornithine degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:1903266 ! regulation of ornithine catabolic process +relationship: positively_regulates GO:0006593 ! ornithine catabolic process + +[Term] +id: GO:1903269 +name: ornithine carbamoyltransferase inhibitor complex +namespace: cellular_component +def: "A protein complex which is capable of ornithine carbamoyltransferase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12679340] +comment: An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). +synonym: "ornithine carbamoyltransferase arginase complex" NARROW [] +synonym: "OTC-ARGI complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1903270 +name: regulation of cytoplasmic translational elongation through polyproline stretches +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation +relationship: regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches + +[Term] +id: GO:1903271 +name: negative regulation of cytoplasmic translational elongation through polyproline stretches +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] +synonym: "down regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie] +is_a: GO:1900248 ! negative regulation of cytoplasmic translational elongation +is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches +relationship: negatively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches + +[Term] +id: GO:1903272 +name: positive regulation of cytoplasmic translational elongation through polyproline stretches +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation through polyproline stretches." [GO_REF:0000058, GOC:TermGenie, PMID:24923804] +synonym: "activation of cytoplasmic translational elongation through polyproline stretches" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic translational elongation through polyproline stretches" EXACT [GOC:TermGenie] +is_a: GO:1900249 ! positive regulation of cytoplasmic translational elongation +is_a: GO:1903270 ! regulation of cytoplasmic translational elongation through polyproline stretches +relationship: positively_regulates GO:0097622 ! cytoplasmic translational elongation through polyproline stretches + +[Term] +id: GO:1903276 +name: regulation of sodium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1903273 +def: "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] +synonym: "regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "regulation of sodium ion export" RELATED [] +synonym: "regulation of sodium ion export from cell" EXACT [] +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +relationship: regulates GO:0036376 ! sodium ion export across plasma membrane + +[Term] +id: GO:1903277 +name: negative regulation of sodium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1903274 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] +synonym: "down regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "down regulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "down regulation of sodium ion export from cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "down-regulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "down-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium export" RELATED [GOC:TermGenie] +synonym: "downregulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "downregulation of sodium ion export from cell" EXACT [GOC:TermGenie] +synonym: "inhibition of sodium export" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium ion export" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium ion export from cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "negative regulation of sodium ion export" RELATED [] +synonym: "negative regulation of sodium ion export from cell" EXACT [] +is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport +is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane +relationship: negatively_regulates GO:0036376 ! sodium ion export across plasma membrane + +[Term] +id: GO:1903278 +name: positive regulation of sodium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1903275 +def: "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17095720] +synonym: "activation of sodium export" NARROW [GOC:TermGenie] +synonym: "activation of sodium ion export" NARROW [GOC:TermGenie] +synonym: "activation of sodium ion export from cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "positive regulation of sodium ion export" RELATED [] +synonym: "positive regulation of sodium ion export from cell" EXACT [] +synonym: "up regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "up regulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "up regulation of sodium ion export from cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium export" RELATED [GOC:TermGenie] +synonym: "up-regulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "up-regulation of sodium ion export from cell" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium export" RELATED [GOC:TermGenie] +synonym: "upregulation of sodium ion export" RELATED [GOC:TermGenie] +synonym: "upregulation of sodium ion export from cell" EXACT [GOC:TermGenie] +is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport +is_a: GO:1903276 ! regulation of sodium ion export across plasma membrane +relationship: positively_regulates GO:0036376 ! sodium ion export across plasma membrane + +[Term] +id: GO:1903279 +name: regulation of calcium:sodium antiporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] +synonym: "regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903280 +name: negative regulation of calcium:sodium antiporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] +synonym: "down regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "down regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "down regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "down-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "down-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "downregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "downregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "inhibition of calcium:sodium antiporter activity" NARROW [GOC:TermGenie] +synonym: "inhibition of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "inhibition of sodium/calcium exchanger" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "negative regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "negative regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity +is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity +is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903281 +name: positive regulation of calcium:sodium antiporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium:sodium antiporter activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19683723] +synonym: "activation of calcium:sodium antiporter activity" NARROW [GOC:TermGenie] +synonym: "activation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "activation of sodium/calcium exchanger" NARROW [GOC:TermGenie] +synonym: "activation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "positive regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "positive regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "up regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "up regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "up-regulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "up-regulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +synonym: "upregulation of calcium:sodium antiporter activity" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial sodium/calcium ion exchange" RELATED [GOC:TermGenie] +synonym: "upregulation of sodium/calcium exchanger" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium:calcium exchange" RELATED [GOC:TermGenie] +is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity +is_a: GO:1903279 ! regulation of calcium:sodium antiporter activity +is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903282 +name: regulation of glutathione peroxidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +is_a: GO:2000468 ! regulation of peroxidase activity + +[Term] +id: GO:1903283 +name: negative regulation of glutathione peroxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GSH peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +is_a: GO:1903282 ! regulation of glutathione peroxidase activity +is_a: GO:2000469 ! negative regulation of peroxidase activity + +[Term] +id: GO:1903284 +name: positive regulation of glutathione peroxidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] +synonym: "activation of glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glutathione:hydrogen-peroxide oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of GSH peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of reduced glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of selenium-glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "enhancement of GPX activity" EXACT [PMID:23507046] +synonym: "positive regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of GSH peroxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of non-selenium glutathione peroxidase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of reduced glutathione peroxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of selenium-glutathione peroxidase activity" EXACT [GOC:TermGenie] +is_a: GO:1903282 ! regulation of glutathione peroxidase activity +is_a: GO:2000470 ! positive regulation of peroxidase activity + +[Term] +id: GO:1903285 +name: positive regulation of hydrogen peroxide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23507046] +synonym: "activation of detoxification of H2O2" RELATED [GOC:TermGenie] +synonym: "activation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "activation of H2O2 catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of H2O2 scavenging" RELATED [GOC:TermGenie] +synonym: "activation of hydrogen peroxide breakdown" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen peroxide catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen peroxide catabolism" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen peroxide degradation" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen peroxide removal" RELATED [GOC:TermGenie] +synonym: "activation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] +synonym: "positive regulation of detoxification of H2O2" RELATED [GOC:TermGenie] +synonym: "positive regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "positive regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of H2O2 scavenging" RELATED [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] +synonym: "up regulation of detoxification of H2O2" RELATED [GOC:TermGenie] +synonym: "up regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "up regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of H2O2 scavenging" RELATED [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] +synonym: "up-regulation of detoxification of H2O2" RELATED [GOC:TermGenie] +synonym: "up-regulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "up-regulation of H2O2 catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of H2O2 scavenging" RELATED [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] +synonym: "upregulation of detoxification of H2O2" RELATED [GOC:TermGenie] +synonym: "upregulation of detoxification of hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "upregulation of H2O2 catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of H2O2 scavenging" RELATED [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide removal" RELATED [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide scavenging" RELATED [GOC:TermGenie] +is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process +relationship: positively_regulates GO:0042744 ! hydrogen peroxide catabolic process + +[Term] +id: GO:1903286 +name: regulation of potassium ion import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of potassium ion import." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] +synonym: "regulation of potassium import" EXACT [GOC:TermGenie] +synonym: "regulation of potassium ion uptake" EXACT [GOC:TermGenie] +is_a: GO:1901379 ! regulation of potassium ion transmembrane transport +relationship: regulates GO:1990573 ! potassium ion import across plasma membrane + +[Term] +id: GO:1903287 +name: negative regulation of potassium ion import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] +synonym: "down regulation of potassium import" BROAD [GOC:TermGenie] +synonym: "down regulation of potassium ion import" BROAD [GOC:TermGenie] +synonym: "down regulation of potassium ion uptake" BROAD [GOC:TermGenie] +synonym: "down-regulation of potassium import" BROAD [GOC:TermGenie] +synonym: "down-regulation of potassium ion import" BROAD [GOC:TermGenie] +synonym: "down-regulation of potassium ion uptake" BROAD [GOC:TermGenie] +synonym: "downregulation of potassium import" BROAD [GOC:TermGenie] +synonym: "downregulation of potassium ion import" BROAD [GOC:TermGenie] +synonym: "downregulation of potassium ion uptake" BROAD [GOC:TermGenie] +synonym: "inhibition of potassium import" NARROW [GOC:TermGenie] +synonym: "inhibition of potassium ion import" NARROW [GOC:TermGenie] +synonym: "inhibition of potassium ion uptake" NARROW [GOC:TermGenie] +synonym: "negative regulation of potassium import" BROAD [GOC:TermGenie] +synonym: "negative regulation of potassium ion import" BROAD [] +synonym: "negative regulation of potassium ion uptake" BROAD [GOC:TermGenie] +is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport +is_a: GO:1903286 ! regulation of potassium ion import +relationship: negatively_regulates GO:1990573 ! potassium ion import across plasma membrane + +[Term] +id: GO:1903288 +name: positive regulation of potassium ion import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:10636900] +synonym: "activation of potassium import" NARROW [GOC:TermGenie] +synonym: "activation of potassium ion import" NARROW [GOC:TermGenie] +synonym: "activation of potassium ion uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of potassium import" EXACT [GOC:TermGenie] +synonym: "positive regulation of potassium ion import" BROAD [] +synonym: "positive regulation of potassium ion uptake" EXACT [GOC:TermGenie] +synonym: "up regulation of potassium import" EXACT [GOC:TermGenie] +synonym: "up regulation of potassium ion import" EXACT [GOC:TermGenie] +synonym: "up regulation of potassium ion uptake" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium import" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium ion import" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium ion uptake" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium import" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium ion import" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium ion uptake" EXACT [GOC:TermGenie] +is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport +is_a: GO:1903286 ! regulation of potassium ion import +relationship: positively_regulates GO:1990573 ! potassium ion import across plasma membrane + +[Term] +id: GO:1903289 +name: obsolete regulation of ATP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:0043462 + +[Term] +id: GO:1903290 +name: obsolete negative regulation of ATP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "down regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "downregulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:0032780 + +[Term] +id: GO:1903291 +name: obsolete positive regulation of ATP catabolic process +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:10636900] +comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. +synonym: "activation of ATP breakdown" NARROW [GOC:TermGenie] +synonym: "activation of ATP catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ATP catabolism" NARROW [GOC:TermGenie] +synonym: "activation of ATP degradation" NARROW [GOC:TermGenie] +synonym: "activation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "up regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP hydrolysis" NARROW [GOC:TermGenie] +synonym: "upregulation of ATP breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP hydrolysis" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:0032781 + +[Term] +id: GO:1903292 +name: protein localization to Golgi membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] +synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] +is_a: GO:0034067 ! protein localization to Golgi apparatus +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1903293 +name: phosphatase complex +namespace: cellular_component +def: "A protein complex which is capable of phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807] +comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1903294 +name: regulation of glutamate secretion, neurotransmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype +is_a: GO:0014048 ! regulation of glutamate secretion +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0051966 ! regulation of synaptic transmission, glutamatergic +relationship: regulates GO:0061535 ! glutamate secretion, neurotransmission + +[Term] +id: GO:1903295 +name: negative regulation of glutamate secretion, neurotransmission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype +synonym: "down regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "inhibition of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] +is_a: GO:0014050 ! negative regulation of glutamate secretion +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:0051967 ! negative regulation of synaptic transmission, glutamatergic +is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission +relationship: negatively_regulates GO:0061535 ! glutamate secretion, neurotransmission + +[Term] +id: GO:1903296 +name: positive regulation of glutamate secretion, neurotransmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter." [GO_REF:0000058, GOC:TermGenie, PMID:16782817] +comment: An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype +synonym: "activation of glutamate secretion, neurotransmission" NARROW [GOC:TermGenie] +synonym: "up regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamate secretion, neurotransmission" EXACT [GOC:TermGenie] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:0014049 ! positive regulation of glutamate secretion +is_a: GO:0051968 ! positive regulation of synaptic transmission, glutamatergic +is_a: GO:1903294 ! regulation of glutamate secretion, neurotransmission +relationship: positively_regulates GO:0061535 ! glutamate secretion, neurotransmission + +[Term] +id: GO:1903297 +name: regulation of hypoxia-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of hypoxia-induced apoptosis" RELATED [GOC:bf] +synonym: "regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf] +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia + +[Term] +id: GO:1903298 +name: negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24553947] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hypoxia" NARROW [GOC:TermGenie] +synonym: "negative regulation of hypoxia-induced apoptosis" RELATED [GOC:bf] +synonym: "negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia" EXACT [GOC:bf] +synonym: "protection against hypoxia-induced apoptosis" RELATED [GOC:bf] +is_a: GO:1900038 ! negative regulation of cellular response to hypoxia +is_a: GO:1903297 ! regulation of hypoxia-induced intrinsic apoptotic signaling pathway +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:1990144 ! intrinsic apoptotic signaling pathway in response to hypoxia + +[Term] +id: GO:1903299 +name: regulation of hexokinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:1903300 +name: negative regulation of hexokinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "down regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "down regulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "down regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "down regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "down regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "down-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "downregulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "downregulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "downregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "downregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase (phosphorylating)" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase D" RELATED [GOC:TermGenie] +synonym: "inhibition of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "inhibition of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "negative regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:1903299 ! regulation of hexokinase activity + +[Term] +id: GO:1903301 +name: positive regulation of hexokinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hexokinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "activation of ATP-dependent hexokinase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP:D-hexose 6-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucose ATP phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase (phosphorylating)" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "activation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "activation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "activation of hexokinase type IV glucokinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "positive regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "up regulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "up regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "up regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "up regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "up-regulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP-dependent hexokinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP:D-hexose 6-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose ATP phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hexokinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "upregulation of hexokinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hexokinase D" RELATED [GOC:TermGenie] +synonym: "upregulation of hexokinase type I activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hexokinase type II activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hexokinase type III activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hexokinase type IV" RELATED [GOC:TermGenie] +synonym: "upregulation of hexokinase type IV (glucokinase) activity" NARROW [GOC:TermGenie] +synonym: "upregulation of hexokinase type IV glucokinase activity" EXACT [GOC:TermGenie] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:1903299 ! regulation of hexokinase activity + +[Term] +id: GO:1903302 +name: regulation of pyruvate kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1903303 +name: negative regulation of pyruvate kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "down regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of pyruvate kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0045820 ! negative regulation of glycolytic process +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1903302 ! regulation of pyruvate kinase activity + +[Term] +id: GO:1903304 +name: positive regulation of pyruvate kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:15804508] +synonym: "activation of ATP:pyruvate 2-O-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphoenol transphosphorylase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphoenolpyruvate kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of pyruvate kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP:pyruvate 2-O-phosphotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphoenol transphosphorylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphoenolpyruvate kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pyruvate kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1903302 ! regulation of pyruvate kinase activity + +[Term] +id: GO:1903305 +name: regulation of regulated secretory pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] +comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. +is_a: GO:0017157 ! regulation of exocytosis +relationship: regulates GO:0045055 ! regulated exocytosis + +[Term] +id: GO:1903306 +name: negative regulation of regulated secretory pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] +comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. +synonym: "down regulation of regulated secretory pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of regulated secretory pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of regulated secretory pathway" NARROW [GOC:TermGenie] +is_a: GO:0045920 ! negative regulation of exocytosis +is_a: GO:1903305 ! regulation of regulated secretory pathway +relationship: negatively_regulates GO:0045055 ! regulated exocytosis + +[Term] +id: GO:1903307 +name: positive regulation of regulated secretory pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of regulated secretory pathway." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:12526776] +comment: An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype. +synonym: "activation of regulated secretory pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of regulated secretory pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulated secretory pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of regulated secretory pathway" EXACT [GOC:TermGenie] +is_a: GO:0045921 ! positive regulation of exocytosis +is_a: GO:1903305 ! regulation of regulated secretory pathway +relationship: positively_regulates GO:0045055 ! regulated exocytosis + +[Term] +id: GO:1903311 +name: regulation of mRNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "regulation of mRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:1903312 +name: negative regulation of mRNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of mRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of mRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: negatively_regulates GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:1903313 +name: positive regulation of mRNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of mRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of mRNA metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:1903311 ! regulation of mRNA metabolic process +relationship: positively_regulates GO:0016071 ! mRNA metabolic process + +[Term] +id: GO:1903314 +name: regulation of nitrogen cycle metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:1903315 +name: negative regulation of nitrogen cycle metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process +relationship: negatively_regulates GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:1903316 +name: positive regulation of nitrogen cycle metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nitrogen cycle metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of nitrogen cycle metabolic process" NARROW [GOC:TermGenie] +synonym: "up regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of nitrogen cycle metabolic process" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1903314 ! regulation of nitrogen cycle metabolic process +relationship: positively_regulates GO:0071941 ! nitrogen cycle metabolic process + +[Term] +id: GO:1903317 +name: regulation of protein maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0051604 ! protein maturation + +[Term] +id: GO:1903318 +name: negative regulation of protein maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein maturation" NARROW [GOC:TermGenie] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1903317 ! regulation of protein maturation +relationship: negatively_regulates GO:0051604 ! protein maturation + +[Term] +id: GO:1903319 +name: positive regulation of protein maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein maturation." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of protein maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1903317 ! regulation of protein maturation +relationship: positively_regulates GO:0051604 ! protein maturation + +[Term] +id: GO:1903320 +name: regulation of protein modification by small protein conjugation or removal +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0070647 ! protein modification by small protein conjugation or removal + +[Term] +id: GO:1903321 +name: negative regulation of protein modification by small protein conjugation or removal +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +synonym: "downregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +synonym: "inhibition of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal + +[Term] +id: GO:1903322 +name: positive regulation of protein modification by small protein conjugation or removal +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie] +synonym: "up regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +synonym: "upregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: positively_regulates GO:0070647 ! protein modification by small protein conjugation or removal + +[Term] +id: GO:1903323 +name: regulation of snoRNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0016074 ! sno(s)RNA metabolic process + +[Term] +id: GO:1903324 +name: negative regulation of snoRNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of snoRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of snoRNA metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:1903323 ! regulation of snoRNA metabolic process +relationship: negatively_regulates GO:0016074 ! sno(s)RNA metabolic process + +[Term] +id: GO:1903325 +name: positive regulation of snoRNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of snoRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of snoRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of snoRNA metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of snoRNA metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of snoRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of snoRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:1903323 ! regulation of snoRNA metabolic process +relationship: positively_regulates GO:0016074 ! sno(s)RNA metabolic process + +[Term] +id: GO:1903326 +name: regulation of tRNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "regulation of tRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0006399 ! tRNA metabolic process + +[Term] +id: GO:1903327 +name: negative regulation of tRNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of tRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of tRNA metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of tRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:1903326 ! regulation of tRNA metabolic process +relationship: negatively_regulates GO:0006399 ! tRNA metabolic process + +[Term] +id: GO:1903328 +name: positive regulation of tRNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA metabolic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of tRNA metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of tRNA metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of tRNA metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of tRNA metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:1903326 ! regulation of tRNA metabolic process +relationship: positively_regulates GO:0006399 ! tRNA metabolic process + +[Term] +id: GO:1903329 +name: regulation of iron-sulfur cluster assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:1903330 +name: negative regulation of iron-sulfur cluster assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of iron-sulfur cluster assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of iron-sulphur cluster assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly +relationship: negatively_regulates GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:1903331 +name: positive regulation of iron-sulfur cluster assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iron-sulfur cluster assembly." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of iron-sulfur cluster assembly" NARROW [GOC:TermGenie] +synonym: "activation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of iron-sulphur cluster assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of iron-sulfur cluster assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of iron-sulfur cluster biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of iron-sulphur cluster assembly" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1903329 ! regulation of iron-sulfur cluster assembly +relationship: positively_regulates GO:0016226 ! iron-sulfur cluster assembly + +[Term] +id: GO:1903332 +name: regulation of protein folding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0006457 ! protein folding + +[Term] +id: GO:1903333 +name: negative regulation of protein folding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "down regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "down regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "down regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "down regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "down regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "down regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "down regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of protein folding" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "down-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "down-regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "down-regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein folding" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "downregulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "downregulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "downregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "downregulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "downregulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "downregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "downregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of protein folding" EXACT [GOC:TermGenie] +synonym: "inhibition of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "inhibition of chaperone activity" RELATED [GOC:TermGenie] +synonym: "inhibition of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "inhibition of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "inhibition of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "inhibition of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "inhibition of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of protein folding" NARROW [GOC:TermGenie] +synonym: "negative regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "negative regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "negative regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903332 ! regulation of protein folding +relationship: negatively_regulates GO:0006457 ! protein folding + +[Term] +id: GO:1903334 +name: positive regulation of protein folding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein folding." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "activation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "activation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "activation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "activation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "activation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "activation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "activation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "activation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "activation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "activation of protein folding" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "positive regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "positive regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "up regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "up regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "up regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "up regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "up regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "up regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "up regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of protein folding" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "up-regulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "up-regulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "up-regulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein folding" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-tubulin folding" NARROW [GOC:TermGenie] +synonym: "upregulation of beta-tubulin folding" NARROW [GOC:TermGenie] +synonym: "upregulation of chaperone activity" RELATED [GOC:TermGenie] +synonym: "upregulation of chaperonin ATPase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of chaperonin-mediated tubulin folding" NARROW [GOC:TermGenie] +synonym: "upregulation of co-chaperone activity" RELATED [GOC:TermGenie] +synonym: "upregulation of co-chaperonin activity" RELATED [GOC:TermGenie] +synonym: "upregulation of glycoprotein-specific chaperone activity" RELATED [GOC:TermGenie] +synonym: "upregulation of non-chaperonin molecular chaperone ATPase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of protein complex assembly, multichaperone pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of protein folding" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903332 ! regulation of protein folding +relationship: positively_regulates GO:0006457 ! protein folding + +[Term] +id: GO:1903335 +name: regulation of vacuolar transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0007034 ! vacuolar transport + +[Term] +id: GO:1903336 +name: negative regulation of vacuolar transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of vacuolar transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of vacuolar transport" EXACT [GOC:TermGenie] +synonym: "downregulation of vacuolar transport" EXACT [GOC:TermGenie] +synonym: "inhibition of vacuolar transport" NARROW [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:1903335 ! regulation of vacuolar transport +relationship: negatively_regulates GO:0007034 ! vacuolar transport + +[Term] +id: GO:1903337 +name: positive regulation of vacuolar transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vacuolar transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of vacuolar transport" NARROW [GOC:TermGenie] +synonym: "up regulation of vacuolar transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of vacuolar transport" EXACT [GOC:TermGenie] +synonym: "upregulation of vacuolar transport" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:1903335 ! regulation of vacuolar transport +relationship: positively_regulates GO:0007034 ! vacuolar transport + +[Term] +id: GO:1903338 +name: regulation of cell wall organization or biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:1903339 +name: negative regulation of cell wall organization or biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cell wall organisation or biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: negatively_regulates GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:1903340 +name: positive regulation of cell wall organization or biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell wall organization or biogenesis." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of cell wall organisation or biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of cell wall organization or biogenesis at cellular level" NARROW [GOC:TermGenie] +synonym: "activation of cellular cell wall organisation or biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of cellular cell wall organization or biogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cell wall organization or biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cell wall organization or biogenesis at cellular level" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular cell wall organisation or biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular cell wall organization or biogenesis" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: positively_regulates GO:0071554 ! cell wall organization or biogenesis + +[Term] +id: GO:1903341 +name: regulation of meiotic DNA double-strand break formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0042138 ! meiotic DNA double-strand break formation + +[Term] +id: GO:1903342 +name: negative regulation of meiotic DNA double-strand break formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] +synonym: "down regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process +is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0042138 ! meiotic DNA double-strand break formation + +[Term] +id: GO:1903343 +name: positive regulation of meiotic DNA double-strand break formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation." [GO_REF:0000058, GOC:TermGenie, PMID:25103240] +synonym: "activation of meiotic DNA double-strand break formation" NARROW [GOC:TermGenie] +synonym: "up regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic DNA double-strand break formation" EXACT [GOC:TermGenie] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0042138 ! meiotic DNA double-strand break formation + +[Term] +id: GO:1903344 +name: regulation of protein polyglycylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0018094 ! protein polyglycylation + +[Term] +id: GO:1903345 +name: negative regulation of protein polyglycylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie] +synonym: "down regulation of protein polyglycylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein polyglycylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein polyglycylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein polyglycylation" NARROW [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1903344 ! regulation of protein polyglycylation +relationship: negatively_regulates GO:0018094 ! protein polyglycylation + +[Term] +id: GO:1903346 +name: positive regulation of protein polyglycylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein polyglycylation." [GO_REF:0000058, GOC:sart, GOC:TermGenie, PMID:21298005] +synonym: "activation of protein polyglycylation" NARROW [GOC:TermGenie] +synonym: "up regulation of protein polyglycylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein polyglycylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein polyglycylation" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1903344 ! regulation of protein polyglycylation +relationship: positively_regulates GO:0018094 ! protein polyglycylation + +[Term] +id: GO:1903347 +name: negative regulation of bicellular tight junction assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] +synonym: "down regulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "downregulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "inhibition of tight junction assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of tight junction formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of tight junction formation" EXACT [GOC:TermGenie] +is_a: GO:1901889 ! negative regulation of cell junction assembly +is_a: GO:2000810 ! regulation of bicellular tight junction assembly +relationship: negatively_regulates GO:0070830 ! bicellular tight junction assembly + +[Term] +id: GO:1903348 +name: positive regulation of bicellular tight junction assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tight junction assembly." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25050009] +synonym: "activation of tight junction assembly" NARROW [GOC:TermGenie] +synonym: "activation of tight junction formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "up regulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of tight junction formation" EXACT [GOC:TermGenie] +synonym: "upregulation of tight junction assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of tight junction formation" EXACT [GOC:TermGenie] +is_a: GO:1901890 ! positive regulation of cell junction assembly +is_a: GO:2000810 ! regulation of bicellular tight junction assembly +relationship: positively_regulates GO:0070830 ! bicellular tight junction assembly + +[Term] +id: GO:1903349 +name: omegasome membrane +namespace: cellular_component +def: "Any membrane that is part of an omegasome." [GO_REF:0000064, GOC:mf, GOC:TermGenie, PMID:18725538, PMID:24591649] +is_a: GO:0098588 ! bounding membrane of organelle +relationship: part_of GO:1990462 ! omegasome + +[Term] +id: GO:1903350 +name: response to dopamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] +is_a: GO:0071869 ! response to catecholamine + +[Term] +id: GO:1903351 +name: cellular response to dopamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:11118945] +is_a: GO:0071870 ! cellular response to catecholamine stimulus +is_a: GO:1903350 ! response to dopamine + +[Term] +id: GO:1903352 +name: L-ornithine transmembrane transport +namespace: biological_process +def: "The directed movement of L-ornithine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015822 ! ornithine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903353 +name: regulation of nucleus organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nucleus organization." [GO_REF:0000058, GOC:TermGenie, PMID:16943282] +synonym: "regulation of nuclear morphology" RELATED [GOC:TermGenie] +synonym: "regulation of nuclear organisation" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear organization" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of nucleus organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0006997 ! nucleus organization + +[Term] +id: GO:1903354 +name: regulation of distal tip cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0097628 ! distal tip cell migration + +[Term] +id: GO:1903355 +name: negative regulation of distal tip cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] +synonym: "down regulation of distal tip cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of distal tip cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of distal tip cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of distal tip cell migration" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:1903354 ! regulation of distal tip cell migration +relationship: negatively_regulates GO:0097628 ! distal tip cell migration + +[Term] +id: GO:1903356 +name: positive regulation of distal tip cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of distal tip cell migration." [GO_REF:0000058, GOC:mm2, GOC:TermGenie, PMID:24968003] +synonym: "activation of distal tip cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of distal tip cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of distal tip cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of distal tip cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:1903354 ! regulation of distal tip cell migration +relationship: positively_regulates GO:0097628 ! distal tip cell migration + +[Term] +id: GO:1903357 +name: regulation of transcription initiation from RNA polymerase I promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter." [GO_REF:0000058, GOC:TermGenie, PMID:9092673] +synonym: "regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW [] +is_a: GO:0006356 ! regulation of transcription by RNA polymerase I +is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation +relationship: regulates GO:0006361 ! transcription initiation from RNA polymerase I promoter + +[Term] +id: GO:1903358 +name: regulation of Golgi organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:17562788] +synonym: "regulation of Golgi organisation" EXACT [GOC:TermGenie] +synonym: "regulation of Golgi organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007030 ! Golgi organization + +[Term] +id: GO:1903359 +name: lateral cortical node assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a lateral cortical node." [GO_REF:0000079, GOC:TermGenie, PMID:25009287] +synonym: "lateral cortical node formation" EXACT [GOC:TermGenie] +synonym: "Skb1-containing cortical node assembly" EXACT [GOC:TermGenie] +synonym: "Skb1-containing cortical node formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1903360 +name: protein localization to lateral cortical node +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node." [GO_REF:0000087, GOC:TermGenie, PMID:25009287] +synonym: "protein localisation in lateral cortical node" EXACT [GOC:TermGenie] +synonym: "protein localisation to lateral cortical node" EXACT [GOC:TermGenie] +synonym: "protein localization in lateral cortical node" EXACT [GOC:TermGenie] +is_a: GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:1903361 +name: protein localization to basolateral plasma membrane +namespace: biological_process +alt_id: GO:0061467 +def: "Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:24785082, PMID:9425351] +synonym: "basolateral protein localization" EXACT [] +synonym: "protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1903362 +name: regulation of cellular protein catabolic process +namespace: biological_process +alt_id: GO:2000598 +def: "Any process that modulates the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] +synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of cyclin breakdown" NARROW [GOC:obol] +synonym: "regulation of cyclin catabolic process" NARROW [] +synonym: "regulation of cyclin catabolism" NARROW [GOC:obol] +synonym: "regulation of cyclin degradation" NARROW [GOC:obol] +synonym: "regulation of degradation of cyclin" NARROW [GOC:obol] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0032268 ! regulation of cellular protein metabolic process +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:1903363 +name: negative regulation of cellular protein catabolic process +namespace: biological_process +alt_id: GO:2000599 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] +synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclin breakdown" NARROW [GOC:obol] +synonym: "negative regulation of cyclin catabolic process" NARROW [] +synonym: "negative regulation of cyclin catabolism" NARROW [GOC:obol] +synonym: "negative regulation of cyclin degradation" NARROW [GOC:obol] +synonym: "negative regulation of degradation of cyclin" NARROW [GOC:obol] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0032269 ! negative regulation of cellular protein metabolic process +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:1903362 ! regulation of cellular protein catabolic process +relationship: negatively_regulates GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:1903364 +name: positive regulation of cellular protein catabolic process +namespace: biological_process +alt_id: GO:2000600 +def: "Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] +synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclin breakdown" NARROW [GOC:obol] +synonym: "positive regulation of cyclin catabolic process" NARROW [] +synonym: "positive regulation of cyclin catabolism" NARROW [GOC:obol] +synonym: "positive regulation of cyclin degradation" NARROW [GOC:obol] +synonym: "positive regulation of degradation of cyclin" NARROW [GOC:obol] +synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0032270 ! positive regulation of cellular protein metabolic process +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:1903362 ! regulation of cellular protein catabolic process +relationship: positively_regulates GO:0044257 ! cellular protein catabolic process + +[Term] +id: GO:1903365 +name: regulation of fear response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +synonym: "regulation of physiological fear response" EXACT [GOC:TermGenie] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0042596 ! fear response + +[Term] +id: GO:1903366 +name: negative regulation of fear response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +synonym: "down regulation of fear response" EXACT [GOC:TermGenie] +synonym: "down regulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "down-regulation of fear response" EXACT [GOC:TermGenie] +synonym: "down-regulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "downregulation of fear response" EXACT [GOC:TermGenie] +synonym: "downregulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "inhibition of fear response" NARROW [GOC:TermGenie] +synonym: "inhibition of physiological fear response" NARROW [GOC:TermGenie] +synonym: "negative regulation of physiological fear response" EXACT [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903365 ! regulation of fear response +relationship: negatively_regulates GO:0042596 ! fear response + +[Term] +id: GO:1903367 +name: positive regulation of fear response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fear response." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +synonym: "activation of fear response" NARROW [GOC:TermGenie] +synonym: "activation of physiological fear response" NARROW [GOC:TermGenie] +synonym: "positive regulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "up regulation of fear response" EXACT [GOC:TermGenie] +synonym: "up regulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "up-regulation of fear response" EXACT [GOC:TermGenie] +synonym: "up-regulation of physiological fear response" EXACT [GOC:TermGenie] +synonym: "upregulation of fear response" EXACT [GOC:TermGenie] +synonym: "upregulation of physiological fear response" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903365 ! regulation of fear response +relationship: positively_regulates GO:0042596 ! fear response + +[Term] +id: GO:1903368 +name: regulation of foraging behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0060756 ! foraging behavior + +[Term] +id: GO:1903369 +name: negative regulation of foraging behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +synonym: "down regulation of foraging behavior" EXACT [GOC:TermGenie] +synonym: "down-regulation of foraging behavior" EXACT [GOC:TermGenie] +synonym: "downregulation of foraging behavior" EXACT [GOC:TermGenie] +synonym: "inhibition of foraging behavior" NARROW [GOC:TermGenie] +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:1903368 ! regulation of foraging behavior +relationship: negatively_regulates GO:0060756 ! foraging behavior + +[Term] +id: GO:1903370 +name: positive regulation of foraging behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of foraging behavior." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:8677262] +synonym: "activation of foraging behavior" NARROW [GOC:TermGenie] +synonym: "up regulation of foraging behavior" EXACT [GOC:TermGenie] +synonym: "up-regulation of foraging behavior" EXACT [GOC:TermGenie] +synonym: "upregulation of foraging behavior" EXACT [GOC:TermGenie] +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:1903368 ! regulation of foraging behavior +relationship: positively_regulates GO:0060756 ! foraging behavior + +[Term] +id: GO:1903371 +name: regulation of endoplasmic reticulum tubular network organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] +synonym: "regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "regulation of ER tubular network organization" EXACT [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0071786 ! endoplasmic reticulum tubular network organization + +[Term] +id: GO:1903372 +name: negative regulation of endoplasmic reticulum tubular network organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] +synonym: "down regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "down regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "downregulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie] +synonym: "inhibition of ER tubular network organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of ER tubular network organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER tubular network organization" EXACT [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization +relationship: negatively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization + +[Term] +id: GO:1903373 +name: positive regulation of endoplasmic reticulum tubular network organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum tubular network organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24891604] +synonym: "activation of endoplasmic reticulum tubular network organisation" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum tubular network organization" NARROW [GOC:TermGenie] +synonym: "activation of ER tubular network organisation" NARROW [GOC:TermGenie] +synonym: "activation of ER tubular network organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "up regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER tubular network organization" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum tubular network organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum tubular network organization" EXACT [GOC:TermGenie] +synonym: "upregulation of ER tubular network organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of ER tubular network organization" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1903371 ! regulation of endoplasmic reticulum tubular network organization +relationship: positively_regulates GO:0071786 ! endoplasmic reticulum tubular network organization + +[Term] +id: GO:1903374 +name: subarachnoid space development +namespace: biological_process +def: "The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure." [GO_REF:0000094, GOC:cjm, GOC:TermGenie, Wikipedia:Subarachnoid_space] +synonym: "cavitas subarachnoidea development" RELATED [GOC:TermGenie] +synonym: "cavum subarachnoideale development" RELATED [GOC:TermGenie] +synonym: "spatium leptomeningeum development" RELATED [GOC:TermGenie] +synonym: "spatium subarachnoideum development" RELATED [GOC:TermGenie] +synonym: "subarachnoid cavity development" RELATED [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0007417 ! central nervous system development + +[Term] +id: GO:1903375 +name: facioacoustic ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] +synonym: "acoustico-facial VII-VIII ganglion complex development" EXACT [UBERON:0012175] +synonym: "acousticofacial ganglion development" EXACT [GOC:TermGenie] +synonym: "facio-acoustic ganglion complex VII-VIII development" EXACT [GOC:TermGenie] +synonym: "facio-acoustic ganglion development" EXACT [GOC:TermGenie] +synonym: "facio-acoustic VII-VIII ganglion complex development" EXACT [GOC:TermGenie] +is_a: GO:0061550 ! cranial ganglion development + +[Term] +id: GO:1903376 +name: regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] +synonym: "regulation of oxidative stress-induced neuron apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of oxidative stress-induced neuronal apoptosis" BROAD [GOC:TermGenie] +is_a: GO:0043523 ! regulation of neuron apoptotic process +is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903203 ! regulation of oxidative stress-induced neuron death +relationship: regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1903377 +name: negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15790595] +synonym: "down regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "inhibition of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] +synonym: "negative regulation of oxidative stress-induced neuron apoptosis" EXACT [GOC:bf] +synonym: "neuroprotection against oxidative stress-induced apoptosis" RELATED [GOC:bf] +synonym: "protection against oxidative stress-induced neuron apoptosis" RELATED [GOC:bf] +synonym: "protection against oxidative stress-induced neuronal apoptosis" RELATED [GOC:bf] +is_a: GO:0043524 ! negative regulation of neuron apoptotic process +is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903204 ! negative regulation of oxidative stress-induced neuron death +is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1903378 +name: positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [] +synonym: "up regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of neuron apoptosis in response to oxidative stress" RELATED [GOC:TermGenie] +synonym: "upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress" EXACT [GOC:TermGenie] +is_a: GO:0043525 ! positive regulation of neuron apoptotic process +is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903223 ! positive regulation of oxidative stress-induced neuron death +is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0036480 ! neuron intrinsic apoptotic signaling pathway in response to oxidative stress + +[Term] +id: GO:1903379 +name: regulation of mitotic chromosome condensation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0060623 ! regulation of chromosome condensation +relationship: regulates GO:0007076 ! mitotic chromosome condensation + +[Term] +id: GO:1903380 +name: positive regulation of mitotic chromosome condensation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:9490640] +synonym: "activation of mitotic chromosome condensation" NARROW [GOC:TermGenie] +synonym: "up regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic chromosome condensation" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1903379 ! regulation of mitotic chromosome condensation +is_a: GO:1905821 ! positive regulation of chromosome condensation +relationship: positively_regulates GO:0007076 ! mitotic chromosome condensation + +[Term] +id: GO:1903381 +name: regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum stress-induced neuron apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of ER stress-induced neuron apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [] +is_a: GO:0043523 ! regulation of neuron apoptotic process +is_a: GO:1902235 ! regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +relationship: regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + +[Term] +id: GO:1903382 +name: negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23453807] +synonym: "down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress" EXACT [] +is_a: GO:0043524 ! negative regulation of neuron apoptotic process +is_a: GO:1902236 ! negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903381 ! regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0036483 ! neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress + +[Term] +id: GO:1903383 +name: regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of H2O2-induced neuron apoptosis" BROAD [GOC:bf] +synonym: "regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen peroxide-induced neuron apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of hydrogen peroxide-induced neuronal apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [] +is_a: GO:1903207 ! regulation of hydrogen peroxide-induced neuron death +is_a: GO:1903376 ! regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +relationship: regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + +[Term] +id: GO:1903384 +name: negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23261939] +synonym: "down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuron apoptosis in response to hydrogen peroxide" RELATED [GOC:TermGenie] +synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [] +synonym: "protection against H2O2-induced neuron apoptosis" RELATED [GOC:bf] +synonym: "protection against hydrogen peroxide-induced neuron apoptosis" RELATED [GOC:bf] +is_a: GO:1903208 ! negative regulation of hydrogen peroxide-induced neuron death +is_a: GO:1903377 ! negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway +is_a: GO:1903383 ! regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway +is_a: GO:1903751 ! negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +relationship: negatively_regulates GO:0036482 ! neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide + +[Term] +id: GO:1903385 +name: regulation of homophilic cell adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules + +[Term] +id: GO:1903386 +name: negative regulation of homophilic cell adhesion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +synonym: "down regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +synonym: "downregulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +synonym: "inhibition of homophilic cell adhesion" NARROW [GOC:TermGenie] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:1903385 ! regulation of homophilic cell adhesion +relationship: negatively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules + +[Term] +id: GO:1903387 +name: positive regulation of homophilic cell adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of homophilic cell adhesion." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +synonym: "activation of homophilic cell adhesion" NARROW [GOC:TermGenie] +synonym: "up regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +synonym: "upregulation of homophilic cell adhesion" EXACT [GOC:TermGenie] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:1903385 ! regulation of homophilic cell adhesion +relationship: positively_regulates GO:0007156 ! homophilic cell adhesion via plasma membrane adhesion molecules + +[Term] +id: GO:1903388 +name: regulation of synaptic vesicle uncoating +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] +synonym: "regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +is_a: GO:1901879 ! regulation of protein depolymerization +relationship: regulates GO:0016191 ! synaptic vesicle uncoating + +[Term] +id: GO:1903389 +name: negative regulation of synaptic vesicle uncoating +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] +synonym: "down regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle uncoating" NARROW [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "negative regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +is_a: GO:1900243 ! negative regulation of synaptic vesicle endocytosis +is_a: GO:1901880 ! negative regulation of protein depolymerization +is_a: GO:1903388 ! regulation of synaptic vesicle uncoating +relationship: negatively_regulates GO:0016191 ! synaptic vesicle uncoating + +[Term] +id: GO:1903390 +name: positive regulation of synaptic vesicle uncoating +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21563316] +synonym: "activation of synaptic vesicle coat depolymerization" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle coat protein depolymerization" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle uncoating" NARROW [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "positive regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle coat depolymerization" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle coat protein depolymerization" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle uncoating" EXACT [GOC:TermGenie] +is_a: GO:1901881 ! positive regulation of protein depolymerization +is_a: GO:1903388 ! regulation of synaptic vesicle uncoating +relationship: positively_regulates GO:0016191 ! synaptic vesicle uncoating + +[Term] +id: GO:1903391 +name: regulation of adherens junction organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +synonym: "regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "regulation of adherens junction organisation" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0034332 ! adherens junction organization + +[Term] +id: GO:1903392 +name: negative regulation of adherens junction organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +synonym: "down regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "down regulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of adherens junction organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of adherens junction organization" EXACT [GOC:TermGenie] +synonym: "downregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of adherens junction organization" EXACT [GOC:TermGenie] +synonym: "inhibition of adherens junction assembly and maintenance" NARROW [GOC:TermGenie] +synonym: "inhibition of adherens junction organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of adherens junction organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "negative regulation of adherens junction organisation" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1903391 ! regulation of adherens junction organization +relationship: negatively_regulates GO:0034332 ! adherens junction organization + +[Term] +id: GO:1903393 +name: positive regulation of adherens junction organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adherens junction organization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:21724833] +synonym: "activation of adherens junction assembly and maintenance" NARROW [GOC:TermGenie] +synonym: "activation of adherens junction organisation" NARROW [GOC:TermGenie] +synonym: "activation of adherens junction organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "positive regulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "up regulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of adherens junction organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "up-regulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of adherens junction organization" EXACT [GOC:TermGenie] +synonym: "upregulation of adherens junction assembly and maintenance" EXACT [GOC:TermGenie] +synonym: "upregulation of adherens junction organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of adherens junction organization" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903391 ! regulation of adherens junction organization +relationship: positively_regulates GO:0034332 ! adherens junction organization + +[Term] +id: GO:1903394 +name: protein localization to kinetochore involved in kinetochore assembly +namespace: biological_process +def: "Any protein localization to kinetochore that is involved in kinetochore assembly." [GO_REF:0000060, GOC:TermGenie, PMID:15369671] +synonym: "condensin localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "condensin localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "condensin localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "condensin localization to kinetochore involved in kinetochore assembly" NARROW [GOC:TermGenie] +synonym: "condensin localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] +synonym: "protein localisation to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "protein localisation to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "protein localisation to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "protein localisation to kinetochore involved in kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "protein localisation to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] +synonym: "protein localization to kinetochore involved in centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "protein localization to kinetochore involved in centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "protein localization to kinetochore involved in chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "protein localization to kinetochore involved in kinetochore formation" RELATED [GOC:TermGenie] +is_a: GO:0034501 ! protein localization to kinetochore +relationship: part_of GO:0051382 ! kinetochore assembly + +[Term] +id: GO:1903395 +name: regulation of secondary cell septum biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:1990344 ! secondary cell septum biogenesis + +[Term] +id: GO:1903396 +name: negative regulation of secondary cell septum biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] +synonym: "down regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of secondary cell septum biogenesis" NARROW [GOC:TermGenie] +is_a: GO:0140280 ! negative regulation of mitotic division septum assembly +is_a: GO:1903395 ! regulation of secondary cell septum biogenesis +relationship: negatively_regulates GO:1990344 ! secondary cell septum biogenesis + +[Term] +id: GO:1903397 +name: positive regulation of secondary cell septum biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:23878277] +synonym: "activation of secondary cell septum biogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of secondary cell septum biogenesis" EXACT [GOC:TermGenie] +is_a: GO:0140281 ! positive regulation of mitotic division septum assembly +is_a: GO:1903395 ! regulation of secondary cell septum biogenesis +relationship: positively_regulates GO:1990344 ! secondary cell septum biogenesis + +[Term] +id: GO:1903398 +name: regulation of m7G(5')pppN diphosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] +synonym: "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of decapase activity" RELATED [GOC:TermGenie] +synonym: "regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1903399 +name: positive regulation of m7G(5')pppN diphosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] +synonym: "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of decapase activity" RELATED [GOC:TermGenie] +synonym: "activation of M(7)G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of m7G(5')pppN diphosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of m7G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of decapase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of decapase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of decapase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of decapase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1903398 ! regulation of m7G(5')pppN diphosphatase activity + +[Term] +id: GO:1903401 +name: L-lysine transmembrane transport +namespace: biological_process +def: "The directed movement of L-lysine across a membrane." [GO_REF:0000069, GOC:krc, GOC:TermGenie, PMID:8195186] +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902022 ! L-lysine transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903402 +name: regulation of renal phosphate excretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] +synonym: "regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +is_a: GO:0044062 ! regulation of excretion +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0044722 ! renal phosphate excretion + +[Term] +id: GO:1903403 +name: negative regulation of renal phosphate excretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] +synonym: "down regulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "down regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "downregulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "downregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "inhibition of renal phosphate excretion" NARROW [GOC:TermGenie] +synonym: "inhibition of renal phosphate ion excretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903402 ! regulation of renal phosphate excretion +relationship: negatively_regulates GO:0044722 ! renal phosphate excretion + +[Term] +id: GO:1903404 +name: positive regulation of renal phosphate excretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of renal phosphate excretion." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:8700837] +synonym: "activation of renal phosphate excretion" NARROW [GOC:TermGenie] +synonym: "activation of renal phosphate ion excretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "up regulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "up regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +synonym: "upregulation of renal phosphate excretion" EXACT [GOC:TermGenie] +synonym: "upregulation of renal phosphate ion excretion" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903402 ! regulation of renal phosphate excretion +relationship: positively_regulates GO:0044722 ! renal phosphate excretion + +[Term] +id: GO:1903405 +name: protein localization to nuclear body +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] +synonym: "protein localisation in nuclear body" EXACT [GOC:TermGenie] +synonym: "protein localisation to nuclear body" EXACT [GOC:TermGenie] +synonym: "protein localization in nuclear body" EXACT [GOC:TermGenie] +is_a: GO:1990173 ! protein localization to nucleoplasm + +[Term] +id: GO:1903406 +name: regulation of P-type sodium:potassium-exchanging transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] +synonym: "regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "regulation of sodium pump" BROAD [GOC:TermGenie] +synonym: "regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of sodium:potassium-exchanging ATPase activity" EXACT [] +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903407 +name: negative regulation of P-type sodium:potassium-exchanging transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] +synonym: "down regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "down regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "down regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "down regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "down-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "down-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "downregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "downregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "downregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie] +synonym: "inhibition of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "inhibition of Na+,K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na+/K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na,K-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "inhibition of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "negative regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "negative regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of sodium:potassium-exchanging ATPase activity" EXACT [] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity +is_a: GO:1903406 ! regulation of P-type sodium:potassium-exchanging transporter activity +is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903408 +name: positive regulation of P-type sodium:potassium-exchanging transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8160880] +synonym: "activation of (Na+ + K+)-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of (Na+ + K+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP phosphohydrolase (Na+/K+-exchanging)" NARROW [GOC:TermGenie] +synonym: "activation of Na(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "activation of Na+,K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na+/K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na,K-activated ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "activation of sodium/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of sodium/potassium-transporting ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of sodium:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of sodium:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "positive regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "positive regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of sodium:potassium-exchanging ATPase activity" EXACT [] +synonym: "up regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "up regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "up regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "up regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "up-regulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "up-regulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of (Na+ + K+)-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of (Na+ + K+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "upregulation of Na(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na+,K+ pump" RELATED [GOC:TermGenie] +synonym: "upregulation of Na+,K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na,K-activated ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Na,K-pump" RELATED [GOC:TermGenie] +synonym: "upregulation of sodium/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium/potassium-transporting ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity +is_a: GO:1903406 ! regulation of P-type sodium:potassium-exchanging transporter activity +is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:1903409 +name: reactive oxygen species biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "reactive oxygen species generation" RELATED [PMID:24252804] +synonym: "reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "ROS formation" RELATED [] +synonym: "ROS generation" RELATED [PMID:24252804] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:1903412 +name: response to bile acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903413 +name: cellular response to bile acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bile acid stimulus." [GO_REF:0000071, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21757002] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1903412 ! response to bile acid + +[Term] +id: GO:1903415 +name: flavonoid transport from endoplasmic reticulum to plant-type vacuole +namespace: biological_process +def: "The directed movement of flavonoid from endoplasmic reticulum to plant-type vacuole." [GO_REF:0000078, GOC:tb, GOC:TermGenie, PMID:25116949] +synonym: "flavonoid accumulation in vacuole" RELATED [] +is_a: GO:0071702 ! organic substance transport + +[Term] +id: GO:1903416 +name: response to glycoside +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus." [GO_REF:0000071, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:12027881, PMID:16243970] +synonym: "cellular response to ouabain" RELATED [CHEBI:472805] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903418 +name: protein localization to plasma membrane of cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:25157670, PMID:27852900] +synonym: "protein localisation in plasma membrane of cell tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to plasma membrane of cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization in plasma membrane of cell tip" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990151 ! protein localization to cell tip +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1903419 +name: protein localization to cortical endoplasmic reticulum +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cortical endoplasmic reticulum." [GO_REF:0000087, GOC:TermGenie, PMID:25103238] +synonym: "protein localisation in cortical endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "protein localisation to cortical endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "protein localization in cortical endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "protein localization to cortical ER" EXACT [] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:1903420 ! protein localization to endoplasmic reticulum tubular network + +[Term] +id: GO:1903420 +name: protein localization to endoplasmic reticulum tubular network +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network." [GO_REF:0000087, GOC:TermGenie, PMID:25103238] +synonym: "protein localisation in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] +synonym: "protein localisation to endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] +synonym: "protein localization in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] +synonym: "protein localization to tubular ER" RELATED [PMID:25103238] +is_a: GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:1903421 +name: regulation of synaptic vesicle recycling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] +comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype +synonym: "regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0036465 ! synaptic vesicle recycling + +[Term] +id: GO:1903422 +name: negative regulation of synaptic vesicle recycling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] +comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype +synonym: "down regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "down regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "down regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +synonym: "down-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "down-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "down-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +synonym: "downregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "downregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "downregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +synonym: "inhibition of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "inhibition of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "negative regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "negative regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1903421 ! regulation of synaptic vesicle recycling +relationship: negatively_regulates GO:0036465 ! synaptic vesicle recycling + +[Term] +id: GO:1903423 +name: positive regulation of synaptic vesicle recycling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle recycling." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22745285] +comment: An example of this is mouse LRRK2 (Q5S006) in PMID:21307259 inferred from mutant phenotype +synonym: "activation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "activation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "activation of synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "positive regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "positive regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "up regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "up regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "up regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +synonym: "up-regulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "up-regulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "up-regulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +synonym: "upregulation of kiss-and-run synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "upregulation of kiss-and-stay synaptic vesicle recycling" NARROW [GOC:TermGenie] +synonym: "upregulation of synaptic vesicle recycling" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1903421 ! regulation of synaptic vesicle recycling +relationship: positively_regulates GO:0036465 ! synaptic vesicle recycling + +[Term] +id: GO:1903424 +name: fluoride transmembrane transport +namespace: biological_process +def: "The process in which fluoride is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:24173035] +synonym: "fluoride membrane transport" EXACT [] +synonym: "transmembrane fluoride transport" EXACT [] +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1903425 +name: fluoride transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of fluoride from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:24173035] +is_a: GO:0015103 ! inorganic anion transmembrane transporter activity + +[Term] +id: GO:1903426 +name: regulation of reactive oxygen species biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "regulation of ROS generation" RELATED [GOC:TermGenie] +is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process +relationship: regulates GO:1903409 ! reactive oxygen species biosynthetic process + +[Term] +id: GO:1903427 +name: negative regulation of reactive oxygen species biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "down regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "down regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "down regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "down regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "down-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "downregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "downregulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species formation" NARROW [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "inhibition of reactive oxygen species synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of ROS formation" RELATED [GOC:TermGenie] +synonym: "inhibition of ROS generation" RELATED [GOC:TermGenie] +synonym: "negative regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "negative regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "prevention of ROS generation" EXACT [PMID:24252804] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process +is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process +relationship: negatively_regulates GO:1903409 ! reactive oxygen species biosynthetic process + +[Term] +id: GO:1903428 +name: positive regulation of reactive oxygen species biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] +synonym: "activation of reactive oxygen species anabolism" NARROW [GOC:TermGenie] +synonym: "activation of reactive oxygen species biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of reactive oxygen species biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of reactive oxygen species formation" NARROW [GOC:TermGenie] +synonym: "activation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "activation of reactive oxygen species synthesis" NARROW [GOC:TermGenie] +synonym: "activation of ROS formation" RELATED [GOC:TermGenie] +synonym: "activation of ROS generation" RELATED [GOC:TermGenie] +synonym: "positive regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "positive regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "up regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "up regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "up-regulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of ROS generation" RELATED [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species formation" EXACT [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species generation" RELATED [GOC:TermGenie] +synonym: "upregulation of reactive oxygen species synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ROS formation" RELATED [GOC:TermGenie] +synonym: "upregulation of ROS generation" RELATED [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process +is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process +relationship: positively_regulates GO:1903409 ! reactive oxygen species biosynthetic process + +[Term] +id: GO:1903429 +name: regulation of cell maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] +synonym: "regulation of functional differentiation" RELATED [GOC:TermGenie] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0048469 ! cell maturation + +[Term] +id: GO:1903430 +name: negative regulation of cell maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] +synonym: "down regulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "down regulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "downregulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "inhibition of cell maturation" NARROW [GOC:TermGenie] +synonym: "inhibition of functional differentiation" RELATED [GOC:TermGenie] +synonym: "negative regulation of functional differentiation" RELATED [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:1903429 ! regulation of cell maturation +relationship: negatively_regulates GO:0048469 ! cell maturation + +[Term] +id: GO:1903431 +name: positive regulation of cell maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell maturation." [GO_REF:0000058, GOC:TermGenie, PMID:17459944] +synonym: "activation of cell maturation" NARROW [GOC:TermGenie] +synonym: "activation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "up regulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "up regulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of functional differentiation" RELATED [GOC:TermGenie] +synonym: "upregulation of cell maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of functional differentiation" RELATED [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:1903429 ! regulation of cell maturation +relationship: positively_regulates GO:0048469 ! cell maturation + +[Term] +id: GO:1903432 +name: regulation of TORC1 signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie] +synonym: "regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +is_a: GO:0032006 ! regulation of TOR signaling +relationship: regulates GO:0038202 ! TORC1 signaling + +[Term] +id: GO:1903433 +name: regulation of constitutive secretory pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] +is_a: GO:0017157 ! regulation of exocytosis +relationship: regulates GO:0045054 ! constitutive secretory pathway + +[Term] +id: GO:1903434 +name: negative regulation of constitutive secretory pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] +synonym: "down regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of constitutive secretory pathway" NARROW [GOC:TermGenie] +is_a: GO:0045920 ! negative regulation of exocytosis +is_a: GO:1903433 ! regulation of constitutive secretory pathway +relationship: negatively_regulates GO:0045054 ! constitutive secretory pathway + +[Term] +id: GO:1903435 +name: positive regulation of constitutive secretory pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of constitutive secretory pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22899725] +synonym: "activation of constitutive secretory pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of constitutive secretory pathway" EXACT [GOC:TermGenie] +is_a: GO:0045921 ! positive regulation of exocytosis +is_a: GO:1903433 ! regulation of constitutive secretory pathway +relationship: positively_regulates GO:0045054 ! constitutive secretory pathway + +[Term] +id: GO:1903436 +name: regulation of mitotic cytokinetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0032954 ! regulation of cytokinetic process +is_a: GO:1902412 ! regulation of mitotic cytokinesis +relationship: regulates GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1903437 +name: negative regulation of mitotic cytokinetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic cytokinetic process" NARROW [GOC:TermGenie] +is_a: GO:1902413 ! negative regulation of mitotic cytokinesis +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: negatively_regulates GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1903438 +name: positive regulation of mitotic cytokinetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of mitotic cytokinetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic cytokinetic process" EXACT [GOC:TermGenie] +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +is_a: GO:1903490 ! positive regulation of mitotic cytokinesis +relationship: positively_regulates GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1903439 +name: calcitonin family receptor complex +namespace: cellular_component +def: "A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:0097648 ! G protein-coupled receptor complex + +[Term] +id: GO:1903440 +name: amylin receptor complex +namespace: cellular_component +def: "A protein complex which is capable of amylin receptor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416] +is_a: GO:1903439 ! calcitonin family receptor complex + +[Term] +id: GO:1903441 +name: protein localization to ciliary membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a ciliary membrane." [GO_REF:0000087, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] +synonym: "protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in ciliary membrane" EXACT [GOC:TermGenie] +is_a: GO:0061512 ! protein localization to cilium +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1903442 +name: response to lipoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1903443 +name: cellular response to lipoic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23232760] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1903442 ! response to lipoic acid + +[Term] +id: GO:1903444 +name: negative regulation of brown fat cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of brown fat cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:23977283] +synonym: "down regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of brown fat cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of brown fat cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of brown adipocyte cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of brown adipocyte differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of brown fat cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of brown adipocyte cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of brown adipocyte differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045599 ! negative regulation of fat cell differentiation +is_a: GO:0090335 ! regulation of brown fat cell differentiation +relationship: negatively_regulates GO:0050873 ! brown fat cell differentiation + +[Term] +id: GO:1903445 +name: protein transport from ciliary membrane to plasma membrane +namespace: biological_process +def: "The directed movement of protein from ciliary membrane to plasma membrane." [GO_REF:0000078, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22139371] +is_a: GO:0032594 ! protein transport within lipid bilayer +is_a: GO:0061951 ! establishment of protein localization to plasma membrane + +[Term] +id: GO:1903446 +name: geraniol metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] +synonym: "geraniol metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016093 ! polyprenol metabolic process +is_a: GO:0016098 ! monoterpenoid metabolic process +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process + +[Term] +id: GO:1903447 +name: geraniol catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] +synonym: "geraniol breakdown" EXACT [GOC:TermGenie] +synonym: "geraniol catabolism" EXACT [GOC:TermGenie] +synonym: "geraniol degradation" EXACT [GOC:TermGenie] +is_a: GO:0016095 ! polyprenol catabolic process +is_a: GO:0016100 ! monoterpenoid catabolic process +is_a: GO:0034310 ! primary alcohol catabolic process +is_a: GO:0120256 ! olefinic compound catabolic process +is_a: GO:1903446 ! geraniol metabolic process + +[Term] +id: GO:1903448 +name: geraniol biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of geraniol." [GO_REF:0000068, GOC:di, GOC:TermGenie, PMID:23200656] +synonym: "geraniol anabolism" EXACT [GOC:TermGenie] +synonym: "geraniol biosynthesis" EXACT [GOC:TermGenie] +synonym: "geraniol formation" EXACT [GOC:TermGenie] +synonym: "geraniol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016094 ! polyprenol biosynthetic process +is_a: GO:0016099 ! monoterpenoid biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1903446 ! geraniol metabolic process + +[Term] +id: GO:1903449 +name: androst-4-ene-3,17-dione biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of androst-4-ene-3,17-dione." [GO_REF:0000068, GOC:mr, GOC:TermGenie, PMID:2028480, PMID:4149619] +synonym: "androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "androstenedione biosynthetic process" EXACT [] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process + +[Term] +id: GO:1903450 +name: regulation of G1 to G0 transition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] +synonym: "regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "regulation of stationary phase" RELATED [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0070314 ! G1 to G0 transition + +[Term] +id: GO:1903451 +name: negative regulation of G1 to G0 transition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] +synonym: "down regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "down regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "down regulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "down regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "down regulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "down-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "down-regulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "down-regulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "downregulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "downregulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "downregulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "downregulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "downregulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "inhibition of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "inhibition of establishment of cell quiescence" NARROW [GOC:TermGenie] +synonym: "inhibition of G1 to G0 transition" NARROW [GOC:TermGenie] +synonym: "inhibition of G1/G0 transition" NARROW [GOC:TermGenie] +synonym: "inhibition of stationary phase" RELATED [GOC:TermGenie] +synonym: "negative regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "negative regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "negative regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "negative regulation of stationary phase" RELATED [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:1903450 ! regulation of G1 to G0 transition +relationship: negatively_regulates GO:0070314 ! G1 to G0 transition + +[Term] +id: GO:1903452 +name: positive regulation of G1 to G0 transition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G1 to G0 transition." [GO_REF:0000058, GOC:di, GOC:TermGenie, PMID:24088570] +synonym: "activation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "activation of establishment of cell quiescence" NARROW [GOC:TermGenie] +synonym: "activation of G1 to G0 transition" NARROW [GOC:TermGenie] +synonym: "activation of G1/G0 transition" NARROW [GOC:TermGenie] +synonym: "activation of stationary phase" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "positive regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "positive regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "positive regulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "up regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "up regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "up regulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "up regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "up regulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "up-regulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "up-regulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "up-regulation of stationary phase" RELATED [GOC:TermGenie] +synonym: "upregulation of cell cycle quiescence" RELATED [GOC:TermGenie] +synonym: "upregulation of establishment of cell quiescence" EXACT [GOC:TermGenie] +synonym: "upregulation of G1 to G0 transition" EXACT [GOC:TermGenie] +synonym: "upregulation of G1/G0 transition" EXACT [GOC:TermGenie] +synonym: "upregulation of stationary phase" RELATED [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1903450 ! regulation of G1 to G0 transition +relationship: positively_regulates GO:0070314 ! G1 to G0 transition + +[Term] +id: GO:1903453 +name: obsolete RNA interference involved in olfactory learning +namespace: biological_process +def: "OBSOLETE. Any RNA interference that is involved in olfactory learning." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:23993094] +comment: This term was obsoleted because it does not represent a specific pathway. +synonym: "posttranscriptional gene silencing by siRNA involved in olfactory learning" EXACT [GOC:TermGenie] +synonym: "RNAi involved in olfactory learning" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903454 +name: regulation of androst-4-ene-3,17-dione biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] +synonym: "regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process + +[Term] +id: GO:1903455 +name: negative regulation of androst-4-ene-3,17-dione biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] +synonym: "down regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "down regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "downregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie] +synonym: "inhibition of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of androstenedione" NARROW [GOC:TermGenie] +synonym: "negative regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process +relationship: negatively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process + +[Term] +id: GO:1903456 +name: positive regulation of androst-4-ene-3,17-dione biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of androst-4-ene-3,17-dione biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:24399684] +synonym: "activation of androst-4-ene-3,17-dione anabolism" NARROW [GOC:TermGenie] +synonym: "activation of androst-4-ene-3,17-dione biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of androst-4-ene-3,17-dione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of androst-4-ene-3,17-dione formation" NARROW [GOC:TermGenie] +synonym: "activation of androst-4-ene-3,17-dione synthesis" NARROW [GOC:TermGenie] +synonym: "activation of androstenedione" NARROW [GOC:TermGenie] +synonym: "positive regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "up regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of androst-4-ene-3,17-dione anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of androst-4-ene-3,17-dione biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of androst-4-ene-3,17-dione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of androst-4-ene-3,17-dione formation" EXACT [GOC:TermGenie] +synonym: "upregulation of androst-4-ene-3,17-dione synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of androstenedione biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1903454 ! regulation of androst-4-ene-3,17-dione biosynthetic process +relationship: positively_regulates GO:1903449 ! androst-4-ene-3,17-dione biosynthetic process + +[Term] +id: GO:1903457 +name: lactate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactate." [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:8941775] +synonym: "lactate breakdown" EXACT [GOC:TermGenie] +synonym: "lactate catabolism" EXACT [GOC:TermGenie] +synonym: "lactate degradation" EXACT [GOC:TermGenie] +is_a: GO:0006089 ! lactate metabolic process +is_a: GO:0072329 ! monocarboxylic acid catabolic process +is_a: GO:1901616 ! organic hydroxy compound catabolic process + +[Term] +id: GO:1903459 +name: mitotic DNA replication lagging strand elongation +namespace: biological_process +def: "Any lagging strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "lagging strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "lagging strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "lagging strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "lagging strand elongation involved in mitotic DNA replication" EXACT [] +synonym: "lagging strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "lagging strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0006273 ! lagging strand elongation +is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication + +[Term] +id: GO:1903460 +name: mitotic DNA replication leading strand elongation +namespace: biological_process +def: "Any leading strand elongation that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "leading strand elongation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "leading strand elongation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "leading strand elongation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "leading strand elongation involved in mitotic DNA replication" EXACT [] +synonym: "leading strand elongation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "leading strand elongation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0006272 ! leading strand elongation +is_a: GO:1902983 ! DNA strand elongation involved in mitotic DNA replication + +[Term] +id: GO:1903461 +name: Okazaki fragment processing involved in mitotic DNA replication +namespace: biological_process +def: "Any DNA replication, Okazaki fragment processing that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "DNA replication, Okazaki fragment processing involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication, Okazaki fragment processing involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication, Okazaki fragment processing involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA replication, Okazaki fragment processing involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0033567 ! DNA replication, Okazaki fragment processing +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1903463 +name: regulation of mitotic cell cycle DNA replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication +relationship: regulates GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1903464 +name: negative regulation of mitotic cell cycle DNA replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "down regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "negative regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0045930 ! negative regulation of mitotic cell cycle +is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication +is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication +relationship: negatively_regulates GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1903465 +name: positive regulation of mitotic cell cycle DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "activation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "activation of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "activation of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "activation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "positive regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "positive regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication +relationship: positively_regulates GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1903466 +name: regulation of mitotic DNA replication initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation +is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication +relationship: regulates GO:1902975 ! mitotic DNA replication initiation + +[Term] +id: GO:1903467 +name: negative regulation of mitotic DNA replication initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation +is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication +is_a: GO:1903466 ! regulation of mitotic DNA replication initiation +relationship: negatively_regulates GO:1902975 ! mitotic DNA replication initiation + +[Term] +id: GO:1903468 +name: positive regulation of DNA replication initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "activation of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] +synonym: "activation of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation +is_a: GO:1903465 ! positive regulation of mitotic cell cycle DNA replication +is_a: GO:1903466 ! regulation of mitotic DNA replication initiation +relationship: positively_regulates GO:1902975 ! mitotic DNA replication initiation + +[Term] +id: GO:1903469 +name: removal of RNA primer involved in mitotic DNA replication +namespace: biological_process +def: "Any DNA replication, removal of RNA primer that is involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "DNA replication, removal of RNA primer involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication, removal of RNA primer involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA replication, removal of RNA primer involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA replication, removal of RNA primer involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "Okazaki initiator RNA removal involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0043137 ! DNA replication, removal of RNA primer +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1903470 +name: obsolete actomyosin contractile ring assembly involved in mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any actomyosin contractile ring assembly that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "constriction ring assembly involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "cytokinesis, actomyosin contractile ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "cytokinesis, actomyosin ring biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "cytokinesis, actomyosin ring formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "cytokinesis, contractile ring assembly involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903471 +name: regulation of mitotic actomyosin contractile ring contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw] +is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:1902404 ! mitotic actomyosin contractile ring contraction + +[Term] +id: GO:1903472 +name: negative regulation of mitotic actomyosin contractile ring contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "down regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie] +synonym: "negative regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw] +is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process +is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction +relationship: negatively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction + +[Term] +id: GO:1903473 +name: positive regulation of mitotic actomyosin contractile ring contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] +synonym: "activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of mitotic actomyosin contractile ring contraction" NARROW [GOC:TermGenie] +synonym: "positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic actomyosin contractile ring constriction" EXACT [GOC:vw] +synonym: "up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic actomyosin contractile ring contraction" EXACT [GOC:TermGenie] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +is_a: GO:1903471 ! regulation of mitotic actomyosin contractile ring contraction +relationship: positively_regulates GO:1902404 ! mitotic actomyosin contractile ring contraction + +[Term] +id: GO:1903474 +name: obsolete anchoring of the mitotic actomyosin contractile ring to the plasma membrane +namespace: biological_process +def: "OBSOLETE. A process that maintains the mitotic actinomyosin contractile ring at the plasma membrane." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:19139265, PMID:28784611] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903475 +name: mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:0000915 ! actomyosin contractile ring assembly +is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis + +[Term] +id: GO:1903476 +name: protein localization to cell division site involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any protein localization to cell division site that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "protein localisation to cell division site involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "protein localization to cell division site involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "protein localization to cell division site involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:1902575 ! protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly + +[Term] +id: GO:1903477 +name: mitotic contractile ring actin filament bundle assembly +namespace: biological_process +def: "Any actin filament bundle assembly that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw] +synonym: "actin filament bundle assembly involved in mitotic actomyosin contractile ring assembly" EXACT [] +is_a: GO:0071519 ! actomyosin contractile ring actin filament bundle assembly +is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903478 +name: actin filament bundle convergence involved in mitotic contractile ring assembly +namespace: biological_process +def: "Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw] +synonym: "actin filament bundle convergence involved in actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "actin filament bundle convergence involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "actin filament bundle convergence involved in cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "actin filament bundle convergence involved in mitotic actomyosin contractile ring assembly" EXACT [] +is_a: GO:0071520 ! actomyosin contractile ring assembly actin filament bundle convergence +is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903479 +name: mitotic actomyosin contractile ring assembly actin filament organization +namespace: biological_process +def: "Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [] +is_a: GO:1903047 ! mitotic cell cycle process +is_a: GO:2000689 ! actomyosin contractile ring assembly actin filament organization +relationship: part_of GO:1903475 ! mitotic actomyosin contractile ring assembly + +[Term] +id: GO:1903480 +name: regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +is_a: GO:1903117 ! regulation of actin filament organization involved in cytokinetic actomyosin contractile ring assembly +relationship: regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903481 +name: negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +is_a: GO:1903500 ! negative regulation of mitotic actomyosin contractile ring assembly +relationship: negatively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903482 +name: positive regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "activation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "activation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "activation of actin filament organization involved in mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +is_a: GO:1903480 ! regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly +relationship: positively_regulates GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1903483 +name: obsolete regulation of maintenance of mitotic actomyosin contractile ring localization +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903484 +name: obsolete negative regulation of maintenance of mitotic actomyosin contractile ring localization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "down regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "inhibition of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "negative regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "negative regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903485 +name: obsolete positive regulation of maintenance of mitotic actomyosin contractile ring localization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of maintenance of mitotic actomyosin contractile ring localization." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "activation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "activation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "activation of maintenance of mitotic actomyosin contractile ring localization" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "positive regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +synonym: "upregulation of cytokinetic ring anchoring involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of maintenance of contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of contractile ring localization involved in cytokinesis during cell cycle involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of maintenance of mitotic actomyosin contractile ring localization" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903486 +name: establishment of mitotic actomyosin contractile ring localization +namespace: biological_process +def: "Any establishment of actomyosin contractile ring localization that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "establishment of actomyosin contractile ring localization involved in mitotic cell cycle" EXACT [] +is_a: GO:0032188 ! establishment of actomyosin contractile ring localization +is_a: GO:1902405 ! mitotic actomyosin contractile ring localization + +[Term] +id: GO:1903487 +name: regulation of lactation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051046 ! regulation of secretion +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0007595 ! lactation + +[Term] +id: GO:1903488 +name: negative regulation of lactation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] +synonym: "down regulation of lactation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactation" EXACT [GOC:TermGenie] +synonym: "downregulation of lactation" EXACT [GOC:TermGenie] +synonym: "inhibition of lactation" NARROW [GOC:TermGenie] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903487 ! regulation of lactation +relationship: negatively_regulates GO:0007595 ! lactation + +[Term] +id: GO:1903489 +name: positive regulation of lactation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lactation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:19563620] +synonym: "activation of lactation" NARROW [GOC:TermGenie] +synonym: "up regulation of lactation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactation" EXACT [GOC:TermGenie] +synonym: "upregulation of lactation" EXACT [GOC:TermGenie] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903487 ! regulation of lactation +relationship: positively_regulates GO:0007595 ! lactation + +[Term] +id: GO:1903490 +name: positive regulation of mitotic cytokinesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:24920823] +synonym: "activation of cytokinesis after mitosis" NARROW [GOC:TermGenie] +synonym: "activation of mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic cytokinesis" EXACT [GOC:TermGenie] +is_a: GO:0032467 ! positive regulation of cytokinesis +is_a: GO:1902412 ! regulation of mitotic cytokinesis +relationship: positively_regulates GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:1903491 +name: response to simvastatin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:23100282] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:0036273 ! response to statin + +[Term] +id: GO:1903492 +name: response to acetylsalicylate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aspirin (acetylsalicylate) stimulus. Aspirin is a non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903493 +name: response to clopidogrel +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clopidogrel stimulus. Clopidogrel is a is an oral, thienopyridine-class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease." [GO_REF:0000071, GOC:TermGenie, PMID:23392654] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903494 +name: response to dehydroepiandrosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1903495 +name: cellular response to dehydroepiandrosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dehydroepiandrosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1903494 ! response to dehydroepiandrosterone + +[Term] +id: GO:1903496 +name: response to 11-deoxycorticosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] +is_a: GO:0051385 ! response to mineralocorticoid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1903497 +name: cellular response to 11-deoxycorticosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 11-deoxycorticosterone stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:3585228] +is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1903496 ! response to 11-deoxycorticosterone + +[Term] +id: GO:1903498 +name: bundle sheath cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a bundle sheath cell." [GO_REF:0000086, GOC:tb, GOC:TermGenie, PMID:24517883] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:1903499 +name: regulation of mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] +synonym: "regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly +relationship: regulates GO:1903475 ! mitotic actomyosin contractile ring assembly + +[Term] +id: GO:1903500 +name: negative regulation of mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] +synonym: "down regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "down regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "downregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie] +synonym: "inhibition of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "inhibition of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] +is_a: GO:1903437 ! negative regulation of mitotic cytokinetic process +is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly +is_a: GO:2000432 ! negative regulation of cytokinesis, actomyosin contractile ring assembly +relationship: negatively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly + +[Term] +id: GO:1903501 +name: positive regulation of mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring assembly." [GO_REF:0000058, GOC:al, GOC:mtg_cell_cycle, GOC:TermGenie, GOC:vw, PMID:18256290] +synonym: "activation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" NARROW [GOC:TermGenie] +synonym: "activation of contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "activation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" NARROW [GOC:TermGenie] +synonym: "activation of mitotic actomyosin contractile ring assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] +synonym: "up regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of actomyosin contractile ring assembly involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic actomyosin contractile ring assembly" EXACT [GOC:TermGenie] +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +is_a: GO:1903499 ! regulation of mitotic actomyosin contractile ring assembly +is_a: GO:2000433 ! positive regulation of cytokinesis, actomyosin contractile ring assembly +relationship: positively_regulates GO:1903475 ! mitotic actomyosin contractile ring assembly + +[Term] +id: GO:1903502 +name: translation repressor complex +namespace: cellular_component +def: "A protein complex which is capable of translation repressor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:14723848] +comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1903503 +name: ATPase inhibitor complex +namespace: cellular_component +def: "A protein complex which is capable of ATPase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16170325] +comment: An example of this is Mago in drome (P49028) in PMID:16170325 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1903504 +name: regulation of mitotic spindle checkpoint +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800] +comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent). +subset: gocheck_do_not_manually_annotate +synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:0090231 ! regulation of spindle checkpoint +relationship: regulates GO:0071174 ! mitotic spindle checkpoint signaling + +[Term] +id: GO:1903505 +name: regulation of establishment of actomyosin contractile ring localization involved in mitotic cell cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of actomyosin contractile ring localization involved in mitotic cell cycle." [GO_REF:0000058, GOC:TermGenie, PMID:24165938] +is_a: GO:0071342 ! regulation of establishment of actomyosin contractile ring localization +is_a: GO:1902471 ! regulation of mitotic actomyosin contractile ring localization +relationship: regulates GO:1903486 ! establishment of mitotic actomyosin contractile ring localization + +[Term] +id: GO:1903506 +name: regulation of nucleic acid-templated transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] +is_a: GO:2001141 ! regulation of RNA biosynthetic process +relationship: regulates GO:0097659 ! nucleic acid-templated transcription + +[Term] +id: GO:1903507 +name: negative regulation of nucleic acid-templated transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] +synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie] +is_a: GO:1902679 ! negative regulation of RNA biosynthetic process +is_a: GO:1903506 ! regulation of nucleic acid-templated transcription +relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription + +[Term] +id: GO:1903508 +name: positive regulation of nucleic acid-templated transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] +synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie] +synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] +is_a: GO:1902680 ! positive regulation of RNA biosynthetic process +is_a: GO:1903506 ! regulation of nucleic acid-templated transcription +relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription + +[Term] +id: GO:1903509 +name: liposaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving liposaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:9452964] +synonym: "liposaccharide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:1903510 +name: mucopolysaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving mucopolysaccharide." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:4236091] +synonym: "mucopolysaccharide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0030203 ! glycosaminoglycan metabolic process + +[Term] +id: GO:1903511 +name: orotic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving orotic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:10727948] +synonym: "orotic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0072527 ! pyrimidine-containing compound metabolic process + +[Term] +id: GO:1903512 +name: phytanic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phytanic acid." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:16799769] +synonym: "phytanic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0001676 ! long-chain fatty acid metabolic process +is_a: GO:0097089 ! methyl-branched fatty acid metabolic process + +[Term] +id: GO:1903513 +name: endoplasmic reticulum to cytosol transport +namespace: biological_process +def: "The directed movement of substances from endoplasmic reticulum to cytosol." [GO_REF:0000076, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] +synonym: "ER to cytosol transport" EXACT [GOC:TermGenie] +is_a: GO:0046907 ! intracellular transport + +[Term] +id: GO:1903514 +name: release of sequestered calcium ion into cytosol by endoplasmic reticulum +namespace: biological_process +def: "The directed movement of calcium ion from endoplasmic reticulum to cytosol." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] +synonym: "calcium ion transport from endoplasmic reticulum to cytosol" BROAD [] +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:1903515 +name: calcium ion transport from cytosol to endoplasmic reticulum +namespace: biological_process +def: "The directed movement of calcium ion from cytosol to endoplasmic reticulum." [GO_REF:0000078, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:16402920] +is_a: GO:0046967 ! cytosol to endoplasmic reticulum transport +is_a: GO:0060401 ! cytosolic calcium ion transport +is_a: GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:1903516 +name: regulation of single strand break repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0000012 ! single strand break repair + +[Term] +id: GO:1903517 +name: negative regulation of single strand break repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] +synonym: "down regulation of single strand break repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of single strand break repair" EXACT [GOC:TermGenie] +synonym: "downregulation of single strand break repair" EXACT [GOC:TermGenie] +synonym: "inhibition of single strand break repair" NARROW [GOC:TermGenie] +is_a: GO:0045738 ! negative regulation of DNA repair +is_a: GO:1903516 ! regulation of single strand break repair +relationship: negatively_regulates GO:0000012 ! single strand break repair + +[Term] +id: GO:1903518 +name: positive regulation of single strand break repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of single strand break repair." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247] +synonym: "activation of single strand break repair" NARROW [GOC:TermGenie] +synonym: "up regulation of single strand break repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of single strand break repair" EXACT [GOC:TermGenie] +synonym: "upregulation of single strand break repair" EXACT [GOC:TermGenie] +is_a: GO:0045739 ! positive regulation of DNA repair +is_a: GO:1903516 ! regulation of single strand break repair +relationship: positively_regulates GO:0000012 ! single strand break repair + +[Term] +id: GO:1903519 +name: regulation of mammary gland involution +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0060056 ! mammary gland involution + +[Term] +id: GO:1903520 +name: negative regulation of mammary gland involution +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] +synonym: "down regulation of mammary gland involution" EXACT [GOC:TermGenie] +synonym: "down-regulation of mammary gland involution" EXACT [GOC:TermGenie] +synonym: "downregulation of mammary gland involution" EXACT [GOC:TermGenie] +synonym: "inhibition of mammary gland involution" NARROW [GOC:TermGenie] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:1903519 ! regulation of mammary gland involution +relationship: negatively_regulates GO:0060056 ! mammary gland involution + +[Term] +id: GO:1903521 +name: positive regulation of mammary gland involution +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mammary gland involution." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23164222] +synonym: "activation of mammary gland involution" NARROW [GOC:TermGenie] +synonym: "up regulation of mammary gland involution" EXACT [GOC:TermGenie] +synonym: "up-regulation of mammary gland involution" EXACT [GOC:TermGenie] +synonym: "upregulation of mammary gland involution" EXACT [GOC:TermGenie] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:1903519 ! regulation of mammary gland involution +relationship: positively_regulates GO:0060056 ! mammary gland involution + +[Term] +id: GO:1903522 +name: regulation of blood circulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] +synonym: "regulation of hemolymph circulation" RELATED [GOC:TermGenie] +is_a: GO:0044057 ! regulation of system process +relationship: regulates GO:0008015 ! blood circulation + +[Term] +id: GO:1903523 +name: negative regulation of blood circulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] +synonym: "down regulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "down regulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "down-regulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "downregulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "downregulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "inhibition of blood circulation" NARROW [GOC:TermGenie] +synonym: "inhibition of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "negative regulation of hemolymph circulation" RELATED [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903522 ! regulation of blood circulation +relationship: negatively_regulates GO:0008015 ! blood circulation + +[Term] +id: GO:1903524 +name: positive regulation of blood circulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood circulation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:10659969] +synonym: "activation of blood circulation" NARROW [GOC:TermGenie] +synonym: "activation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "positive regulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "up regulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "up regulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "up-regulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemolymph circulation" RELATED [GOC:TermGenie] +synonym: "upregulation of blood circulation" EXACT [GOC:TermGenie] +synonym: "upregulation of hemolymph circulation" RELATED [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903522 ! regulation of blood circulation +relationship: positively_regulates GO:0008015 ! blood circulation + +[Term] +id: GO:1903525 +name: regulation of membrane tubulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] +synonym: "regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "regulation of vesicle scission" RELATED [GOC:TermGenie] +is_a: GO:1903729 ! regulation of plasma membrane organization +relationship: regulates GO:0097320 ! plasma membrane tubulation + +[Term] +id: GO:1903526 +name: negative regulation of membrane tubulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] +synonym: "down regulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "down regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "downregulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane tubulation" NARROW [GOC:TermGenie] +synonym: "inhibition of plasma membrane tubulation" NARROW [GOC:TermGenie] +synonym: "negative regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1903525 ! regulation of membrane tubulation +relationship: negatively_regulates GO:0097320 ! plasma membrane tubulation + +[Term] +id: GO:1903527 +name: positive regulation of membrane tubulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane tubulation." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:18388313] +synonym: "activation of membrane tubulation" NARROW [GOC:TermGenie] +synonym: "activation of plasma membrane tubulation" NARROW [GOC:TermGenie] +synonym: "positive regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "up regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane tubulation" EXACT [GOC:TermGenie] +synonym: "upregulation of plasma membrane tubulation" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903525 ! regulation of membrane tubulation +relationship: positively_regulates GO:0097320 ! plasma membrane tubulation + +[Term] +id: GO:1903528 +name: regulation of dCDP biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005] +synonym: "regulation of dCDP anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of dCDP formation" EXACT [GOC:TermGenie] +synonym: "regulation of dCDP synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900397 ! regulation of pyrimidine nucleotide biosynthetic process +relationship: regulates GO:0006240 ! dCDP biosynthetic process + +[Term] +id: GO:1903529 +name: negative regulation of dCDP biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dCDP biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:16317005] +synonym: "down regulation of dCDP anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of dCDP formation" EXACT [GOC:TermGenie] +synonym: "down regulation of dCDP synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dCDP anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of dCDP formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of dCDP synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dCDP anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of dCDP biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of dCDP biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of dCDP formation" EXACT [GOC:TermGenie] +synonym: "downregulation of dCDP synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of dCDP anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of dCDP biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of dCDP biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of dCDP formation" NARROW [GOC:TermGenie] +synonym: "inhibition of dCDP synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of dCDP anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of dCDP biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of dCDP formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of dCDP synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900398 ! negative regulation of pyrimidine nucleotide biosynthetic process +is_a: GO:1903528 ! regulation of dCDP biosynthetic process +relationship: negatively_regulates GO:0006240 ! dCDP biosynthetic process + +[Term] +id: GO:1903530 +name: regulation of secretion by cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] +synonym: "regulation of cellular secretion" EXACT [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:0051046 ! regulation of secretion +relationship: regulates GO:0032940 ! secretion by cell + +[Term] +id: GO:1903531 +name: negative regulation of secretion by cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] +synonym: "down regulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of secretion by cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of secretion by cell" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of secretion by cell" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of secretion by cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular secretion" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:1903530 ! regulation of secretion by cell +relationship: negatively_regulates GO:0032940 ! secretion by cell + +[Term] +id: GO:1903532 +name: positive regulation of secretion by cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secretion by cell." [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] +synonym: "activation of cellular secretion" NARROW [GOC:TermGenie] +synonym: "activation of secretion by cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of secretion by cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of secretion by cell" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of secretion by cell" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:1903530 ! regulation of secretion by cell +relationship: positively_regulates GO:0032940 ! secretion by cell + +[Term] +id: GO:1903533 +name: regulation of protein targeting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein targeting." [GO_REF:0000058, GOC:TermGenie] +synonym: "regulation of nascent polypeptide association" RELATED [GOC:TermGenie] +synonym: "regulation of protein sorting along secretory pathway" NARROW [GOC:TermGenie] +is_a: GO:0033157 ! regulation of intracellular protein transport +relationship: regulates GO:0006605 ! protein targeting + +[Term] +id: GO:1903534 +name: regulation of lactose biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] +synonym: "regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "regulation of lactose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0005989 ! lactose biosynthetic process + +[Term] +id: GO:1903535 +name: negative regulation of lactose biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] +synonym: "down regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "down regulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "downregulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of lactose anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of lactose biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of lactose biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of lactose formation" NARROW [GOC:TermGenie] +synonym: "inhibition of lactose synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of lactose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:1903534 ! regulation of lactose biosynthetic process +relationship: negatively_regulates GO:0005989 ! lactose biosynthetic process + +[Term] +id: GO:1903536 +name: positive regulation of lactose biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lactose biosynthetic process." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:12018418] +synonym: "activation of lactose anabolism" NARROW [GOC:TermGenie] +synonym: "activation of lactose biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of lactose biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of lactose formation" NARROW [GOC:TermGenie] +synonym: "activation of lactose synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "up regulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lactose synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of lactose anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of lactose biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of lactose biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of lactose formation" EXACT [GOC:TermGenie] +synonym: "upregulation of lactose synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:1903534 ! regulation of lactose biosynthetic process +relationship: positively_regulates GO:0005989 ! lactose biosynthetic process + +[Term] +id: GO:1903537 +name: meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any meiotic cell cycle process that is involved in oocyte maturation." [GO_REF:0000060, GOC:jz, GOC:TermGenie, PMID:25212395] +synonym: "meiosis involved in oocyte maturation" BROAD [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0001556 ! oocyte maturation + +[Term] +id: GO:1903538 +name: regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:jz, GOC:TermGenie, PMID:25212395] +synonym: "regulation of meiosis involved in oocyte maturation" BROAD [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation + +[Term] +id: GO:1903539 +name: protein localization to postsynaptic membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322] +synonym: "protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] +is_a: GO:0062237 ! protein localization to postsynapse +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1903540 +name: establishment of protein localization to postsynaptic membrane +namespace: biological_process +def: "The directed movement of a protein to a specific location in a postsynaptic membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:9753322] +synonym: "establishment of protein localisation in postsynaptic membrane" EXACT [GOC:TermGenie] +synonym: "establishment of protein localisation to postsynaptic membrane" EXACT [GOC:TermGenie] +synonym: "establishment of protein localization in postsynaptic membrane" EXACT [GOC:TermGenie] +is_a: GO:0090150 ! establishment of protein localization to membrane +is_a: GO:1903539 ! protein localization to postsynaptic membrane + +[Term] +id: GO:1903541 +name: regulation of exosomal secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "regulation of secretion of exosome" EXACT [GOC:TermGenie] +is_a: GO:0017157 ! regulation of exocytosis +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:1990182 ! exosomal secretion + +[Term] +id: GO:1903542 +name: negative regulation of exosomal secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "down regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "downregulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "inhibition of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of exosomal secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of exosomal secretory pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of secretion of exosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "negative regulation of secretion of exosome" EXACT [GOC:TermGenie] +is_a: GO:0045920 ! negative regulation of exocytosis +is_a: GO:1903541 ! regulation of exosomal secretion +relationship: negatively_regulates GO:1990182 ! exosomal secretion + +[Term] +id: GO:1903543 +name: positive regulation of exosomal secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exosomal secretion." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "activation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "activation of exosomal secretion" NARROW [GOC:TermGenie] +synonym: "activation of exosomal secretory pathway" NARROW [GOC:TermGenie] +synonym: "activation of extracellular vesicular exosome secretion" NARROW [GOC:TermGenie] +synonym: "activation of secretion of exosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "positive regulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "up regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of secretion of exosome" EXACT [GOC:TermGenie] +synonym: "upregulation of exosomal protein secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of exosomal secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of exosomal secretory pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular vesicular exosome secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of secretion of exosome" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0045921 ! positive regulation of exocytosis +is_a: GO:1903541 ! regulation of exosomal secretion +relationship: positively_regulates GO:1990182 ! exosomal secretion + +[Term] +id: GO:1903544 +name: response to butyrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1903545 +name: cellular response to butyrate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a butyrate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9734870] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:1903544 ! response to butyrate + +[Term] +id: GO:1903546 +name: protein localization to photoreceptor outer segment +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment." [GO_REF:0000087, GOC:TermGenie, PMID:11481257, PMID:21867699] +synonym: "protein localisation in photoreceptor outer segment" EXACT [GOC:TermGenie] +synonym: "protein localisation to photoreceptor outer segment" EXACT [GOC:TermGenie] +synonym: "protein localization in photoreceptor outer segment" EXACT [GOC:TermGenie] +is_a: GO:0097499 ! protein localization to non-motile cilium + +[Term] +id: GO:1903547 +name: regulation of growth hormone activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] +synonym: "regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1903548 +name: negative regulation of growth hormone activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] +synonym: "down regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "down regulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "down regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "down regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "downregulation of GH activity" EXACT [GOC:TermGenie] +synonym: "downregulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "downregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "downregulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GH activity" NARROW [GOC:TermGenie] +synonym: "inhibition of growth hormone activity" NARROW [GOC:TermGenie] +synonym: "inhibition of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "inhibition of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +is_a: GO:1900121 ! negative regulation of receptor binding +is_a: GO:1903547 ! regulation of growth hormone activity + +[Term] +id: GO:1903549 +name: positive regulation of growth hormone activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of growth hormone activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:3068266] +synonym: "activation of GH activity" NARROW [GOC:TermGenie] +synonym: "activation of growth hormone activity" NARROW [GOC:TermGenie] +synonym: "activation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "activation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "up regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "up regulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "up regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of GH activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of placental growth hormone activity" NARROW [GOC:TermGenie] +synonym: "upregulation of GH activity" EXACT [GOC:TermGenie] +synonym: "upregulation of growth hormone activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pituitary growth hormone activity" NARROW [GOC:TermGenie] +synonym: "upregulation of placental growth hormone activity" NARROW [GOC:TermGenie] +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:1903547 ! regulation of growth hormone activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1903551 +name: regulation of extracellular exosome assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0071971 ! extracellular exosome assembly + +[Term] +id: GO:1903552 +name: negative regulation of extracellular exosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "down regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of extracellular vesicular exosome assembly" EXACT [GOC:vesicles] +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:1903551 ! regulation of extracellular exosome assembly +relationship: negatively_regulates GO:0071971 ! extracellular exosome assembly + +[Term] +id: GO:1903553 +name: positive regulation of extracellular exosome assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24105262] +synonym: "activation of extracellular vesicular exosome assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of extracellular vesicular exosome assembly" RELATED [GOC:vesicles] +synonym: "up regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of extracellular vesicular exosome assembly" EXACT [GOC:TermGenie] +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:1903551 ! regulation of extracellular exosome assembly +relationship: positively_regulates GO:0071971 ! extracellular exosome assembly + +[Term] +id: GO:1903554 +name: G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium +namespace: biological_process +def: "Any G protein-coupled receptor signaling pathway that is involved in defense response to Gram-negative bacterium." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:25303524] +synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in defence response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacteria" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in defense response to Gram-negative bacterium" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in Gram-negative antibacterial peptide activity" RELATED [GOC:TermGenie] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium + +[Term] +id: GO:1903555 +name: regulation of tumor necrosis factor superfamily cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:1903556 +name: negative regulation of tumor necrosis factor superfamily cytokine production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "down regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "down regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "down regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +synonym: "down-regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "down-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "down-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +synonym: "downregulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "downregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "downregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +synonym: "inhibition of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "inhibition of TNFSF cytokine production" NARROW [GOC:TermGenie] +synonym: "inhibition of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] +synonym: "negative regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "negative regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: negatively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:1903557 +name: positive regulation of tumor necrosis factor superfamily cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor superfamily cytokine production." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "activation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "activation of TNFSF cytokine production" NARROW [GOC:TermGenie] +synonym: "activation of tumor necrosis factor superfamily cytokine production" NARROW [GOC:TermGenie] +synonym: "positive regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "positive regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "up regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "up regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "up regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +synonym: "up-regulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "up-regulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "up-regulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +synonym: "upregulation of TNF superfamily production" RELATED [GOC:TermGenie] +synonym: "upregulation of TNFSF cytokine production" EXACT [GOC:TermGenie] +synonym: "upregulation of tumor necrosis factor superfamily cytokine production" EXACT [GOC:TermGenie] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: positively_regulates GO:0071706 ! tumor necrosis factor superfamily cytokine production + +[Term] +id: GO:1903558 +name: 3-cyano-L-alanine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] +synonym: "3-cyano-L-alanine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0033052 ! cyanoamino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:1903559 +name: 3-cyano-L-alanine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] +synonym: "3-cyano-L-alanine breakdown" EXACT [GOC:TermGenie] +synonym: "3-cyano-L-alanine catabolism" EXACT [GOC:TermGenie] +synonym: "3-cyano-L-alanine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0050899 ! nitrile catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process +is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process + +[Term] +id: GO:1903560 +name: 3-cyano-L-alanine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of 3-cyano-L-alanine." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:24100226, pmid:24843024] +synonym: "3-cyano-L-alanine anabolism" EXACT [GOC:TermGenie] +synonym: "3-cyano-L-alanine biosynthesis" EXACT [GOC:TermGenie] +synonym: "3-cyano-L-alanine formation" EXACT [GOC:TermGenie] +synonym: "3-cyano-L-alanine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0080028 ! nitrile biosynthetic process +is_a: GO:1901607 ! alpha-amino acid biosynthetic process +is_a: GO:1903558 ! 3-cyano-L-alanine metabolic process + +[Term] +id: GO:1903561 +name: extracellular vesicle +namespace: cellular_component +def: "Any vesicle that is part of the extracellular region." [GO_REF:0000064, GOC:pm, GOC:TermGenie, PMID:24769233] +synonym: "microparticle" RELATED [GOC:vesicles] +is_a: GO:0031982 ! vesicle +is_a: GO:0065010 ! extracellular membrane-bounded organelle + +[Term] +id: GO:1903562 +name: microtubule bundle formation involved in mitotic spindle midzone assembly +namespace: biological_process +def: "Any microtubule bundle formation that is involved in spindle midzone assembly involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:15647375] +synonym: "microtubule bundle formation involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie] +synonym: "microtubule bundle formation involved in spindle midzone assembly involved in mitosis" EXACT [GOC:dos] +synonym: "microtubule bundling involved in mitotic spindle midzone assembly" RELATED [GOC:TermGenie] +synonym: "microtubule bundling involved in mitotic spindle midzone formation" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in spindle midzone assembly involved in mitosis" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in spindle midzone biogenesis involved in mitosis" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in spindle midzone formation involved in mitosis" EXACT [GOC:TermGenie] +is_a: GO:0001578 ! microtubule bundle formation +is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis +relationship: part_of GO:0051256 ! mitotic spindle midzone assembly + +[Term] +id: GO:1903563 +name: microtubule bundle formation involved in horsetail-astral microtubule organization +namespace: biological_process +def: "Any microtubule bundle formation that is involved in horsetail-astral microtubule organization." [GO_REF:0000060, GOC:TermGenie, PMID:15647375] +synonym: "microtubule bundle formation involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie] +synonym: "microtubule bundle formation involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in horsetail-astral microtubule array organization" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in horsetail-astral microtubule organisation" EXACT [GOC:TermGenie] +synonym: "microtubule bundling involved in horsetail-astral microtubule organization" EXACT [GOC:TermGenie] +is_a: GO:0001578 ! microtubule bundle formation +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0032118 ! horsetail-astral microtubule organization + +[Term] +id: GO:1903564 +name: regulation of protein localization to cilium +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0061512 ! protein localization to cilium + +[Term] +id: GO:1903565 +name: negative regulation of protein localization to cilium +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +synonym: "down regulation of protein localization to cilium" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cilium" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cilium" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localization to cilium" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903564 ! regulation of protein localization to cilium +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0061512 ! protein localization to cilium + +[Term] +id: GO:1903566 +name: positive regulation of protein localization to cilium +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cilium." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +synonym: "activation of protein localization to cilium" NARROW [GOC:TermGenie] +synonym: "up regulation of protein localization to cilium" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cilium" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cilium" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903564 ! regulation of protein localization to cilium +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0061512 ! protein localization to cilium + +[Term] +id: GO:1903567 +name: regulation of protein localization to ciliary membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +synonym: "regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +is_a: GO:1903564 ! regulation of protein localization to cilium +is_a: GO:1904375 ! regulation of protein localization to cell periphery +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:1903441 ! protein localization to ciliary membrane + +[Term] +id: GO:1903568 +name: negative regulation of protein localization to ciliary membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +synonym: "down regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in ciliary membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to ciliary membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +is_a: GO:1903565 ! negative regulation of protein localization to cilium +is_a: GO:1903567 ! regulation of protein localization to ciliary membrane +is_a: GO:1904376 ! negative regulation of protein localization to cell periphery +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:1903441 ! protein localization to ciliary membrane + +[Term] +id: GO:1903569 +name: positive regulation of protein localization to ciliary membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:22072986] +synonym: "activation of protein localisation in ciliary membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to ciliary membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in ciliary membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to ciliary membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to ciliary membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in ciliary membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to ciliary membrane" EXACT [GOC:TermGenie] +is_a: GO:1903566 ! positive regulation of protein localization to cilium +is_a: GO:1903567 ! regulation of protein localization to ciliary membrane +is_a: GO:1904377 ! positive regulation of protein localization to cell periphery +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:1903441 ! protein localization to ciliary membrane + +[Term] +id: GO:1903570 +name: regulation of protein kinase D signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +synonym: "regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +is_a: GO:1902531 ! regulation of intracellular signal transduction +relationship: regulates GO:0089700 ! protein kinase D signaling + +[Term] +id: GO:1903571 +name: negative regulation of protein kinase D signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +synonym: "down regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "down regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "down regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "inhibition of PKD signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "inhibition of protein kinase D signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of protein kinase D signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "inhibition of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +is_a: GO:1903570 ! regulation of protein kinase D signaling +relationship: negatively_regulates GO:0089700 ! protein kinase D signaling + +[Term] +id: GO:1903572 +name: positive regulation of protein kinase D signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein kinase D signaling." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20497126] +synonym: "activation of PKD signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "activation of protein kinase D signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of protein kinase D signaling" NARROW [GOC:TermGenie] +synonym: "activation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "activation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "positive regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of PKD signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of PKD signaling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of protein kinase D signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of protein kinase D signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of protein kinase D signaling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of protein kinase D signalling cascade" RELATED [GOC:TermGenie] +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +is_a: GO:1903570 ! regulation of protein kinase D signaling +relationship: positively_regulates GO:0089700 ! protein kinase D signaling + +[Term] +id: GO:1903573 +name: negative regulation of response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] +synonym: "down regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "down regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down regulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "downregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "inhibition of ER stress response" NARROW [GOC:TermGenie] +synonym: "inhibition of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "inhibition of response to ER stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to ER stress" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +relationship: negatively_regulates GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:1903574 +name: negative regulation of cellular response to amino acid starvation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to amino acid starvation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] +synonym: "down regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to amino acid starvation" NARROW [GOC:TermGenie] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0032108 ! negative regulation of response to nutrient levels +is_a: GO:1903832 ! regulation of cellular response to amino acid starvation +relationship: negatively_regulates GO:0034198 ! cellular response to amino acid starvation + +[Term] +id: GO:1903575 +name: cornified envelope assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a cornified envelope." [GO_REF:0000079, GOC:pm, GOC:TermGenie, PMID:22226963, PMID:24794495] +comment: An example of this is syntaxin 4 in PMID:22226963. +synonym: "cornified envelope formation" EXACT [GOC:TermGenie] +is_a: GO:0007009 ! plasma membrane organization +is_a: GO:0071709 ! membrane assembly + +[Term] +id: GO:1903576 +name: response to L-arginine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1903577 +name: cellular response to L-arginine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:6394628] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1903576 ! response to L-arginine + +[Term] +id: GO:1903578 +name: regulation of ATP metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] +synonym: "regulation of ATP metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019222 ! regulation of metabolic process +relationship: regulates GO:0046034 ! ATP metabolic process + +[Term] +id: GO:1903579 +name: negative regulation of ATP metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] +synonym: "down regulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of ATP metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: negatively_regulates GO:0046034 ! ATP metabolic process + +[Term] +id: GO:1903580 +name: positive regulation of ATP metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ATP metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:20695849] +synonym: "activation of ATP metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of ATP metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP metabolism" EXACT [GOC:TermGenie] +is_a: GO:0009893 ! positive regulation of metabolic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: positively_regulates GO:0046034 ! ATP metabolic process + +[Term] +id: GO:1903581 +name: regulation of basophil degranulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] +is_a: GO:0002694 ! regulation of leukocyte activation +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +is_a: GO:0043300 ! regulation of leukocyte degranulation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002561 ! basophil degranulation + +[Term] +id: GO:1903582 +name: negative regulation of basophil degranulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] +synonym: "down regulation of basophil degranulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of basophil degranulation" EXACT [GOC:TermGenie] +synonym: "downregulation of basophil degranulation" EXACT [GOC:TermGenie] +synonym: "inhibition of basophil degranulation" NARROW [GOC:TermGenie] +is_a: GO:0002695 ! negative regulation of leukocyte activation +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:0043301 ! negative regulation of leukocyte degranulation +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:1903581 ! regulation of basophil degranulation +relationship: negatively_regulates GO:0002561 ! basophil degranulation + +[Term] +id: GO:1903583 +name: positive regulation of basophil degranulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of basophil degranulation." [GO_REF:0000058, GOC:TermGenie, PMID:10880837] +synonym: "activation of basophil degranulation" NARROW [GOC:TermGenie] +synonym: "up regulation of basophil degranulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of basophil degranulation" EXACT [GOC:TermGenie] +synonym: "upregulation of basophil degranulation" EXACT [GOC:TermGenie] +is_a: GO:0002696 ! positive regulation of leukocyte activation +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:0043302 ! positive regulation of leukocyte degranulation +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:1903581 ! regulation of basophil degranulation +relationship: positively_regulates GO:0002561 ! basophil degranulation + +[Term] +id: GO:1903584 +name: regulation of histone deubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689] +synonym: "regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0090085 ! regulation of protein deubiquitination +relationship: regulates GO:0016578 ! histone deubiquitination + +[Term] +id: GO:1903585 +name: negative regulation of histone deubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689] +synonym: "down regulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone deubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of histone deubiquitinylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone deubiquitylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0090086 ! negative regulation of protein deubiquitination +is_a: GO:1903584 ! regulation of histone deubiquitination +relationship: negatively_regulates GO:0016578 ! histone deubiquitination + +[Term] +id: GO:1903586 +name: positive regulation of histone deubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone deubiquitination." [GO_REF:0000058, GOC:TermGenie, PMID:24526689] +synonym: "activation of histone deubiquitination" NARROW [GOC:TermGenie] +synonym: "activation of histone deubiquitinylation" NARROW [GOC:TermGenie] +synonym: "activation of histone deubiquitylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "up regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone deubiquitylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone deubiquitination" EXACT [GOC:TermGenie] +synonym: "upregulation of histone deubiquitinylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone deubiquitylation" EXACT [GOC:TermGenie] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:1903003 ! positive regulation of protein deubiquitination +is_a: GO:1903584 ! regulation of histone deubiquitination +relationship: positively_regulates GO:0016578 ! histone deubiquitination + +[Term] +id: GO:1903587 +name: regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] +synonym: "regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +relationship: regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis + +[Term] +id: GO:1903588 +name: negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] +synonym: "down regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +is_a: GO:0001937 ! negative regulation of endothelial cell proliferation +is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis +relationship: negatively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis + +[Term] +id: GO:1903589 +name: positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:23388056] +synonym: "activation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "activation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis" EXACT [GOC:TermGenie] +is_a: GO:0001938 ! positive regulation of endothelial cell proliferation +is_a: GO:1903587 ! regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis +relationship: positively_regulates GO:0002043 ! blood vessel endothelial cell proliferation involved in sprouting angiogenesis + +[Term] +id: GO:1903590 +name: regulation of lysozyme activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] +synonym: "regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1903591 +name: negative regulation of lysozyme activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] +synonym: "down regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "down regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "down regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "down regulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "down regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "down regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "down-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "down-regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "down-regulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "down-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "downregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of globulin G" RELATED [GOC:TermGenie] +synonym: "downregulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "downregulation of L-7001" RELATED [GOC:TermGenie] +synonym: "downregulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "downregulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "downregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "inhibition of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of globulin G" RELATED [GOC:TermGenie] +synonym: "inhibition of globulin G1" RELATED [GOC:TermGenie] +synonym: "inhibition of L-7001" RELATED [GOC:TermGenie] +synonym: "inhibition of lysozyme activity" NARROW [GOC:TermGenie] +synonym: "inhibition of lysozyme g" RELATED [GOC:TermGenie] +synonym: "inhibition of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of muramidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "negative regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "negative regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "negative regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "negative regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "negative regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:1903590 ! regulation of lysozyme activity + +[Term] +id: GO:1903592 +name: positive regulation of lysozyme activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lysozyme activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:23954697] +synonym: "activation of 1,4-N-acetylmuramidase activity" NARROW [GOC:TermGenie] +synonym: "activation of globulin G" RELATED [GOC:TermGenie] +synonym: "activation of globulin G1" RELATED [GOC:TermGenie] +synonym: "activation of L-7001" RELATED [GOC:TermGenie] +synonym: "activation of lysozyme activity" NARROW [GOC:TermGenie] +synonym: "activation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "activation of mucopeptide glucohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of mucopeptide N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of muramidase activity" NARROW [GOC:TermGenie] +synonym: "activation of N,O-diacetylmuramidase activity" NARROW [GOC:TermGenie] +synonym: "activation of peptidoglycan N-acetylmuramoylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "positive regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "positive regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "positive regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "positive regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "up regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "up regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "up regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "up regulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "up regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "up regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of globulin G" RELATED [GOC:TermGenie] +synonym: "up-regulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-7001" RELATED [GOC:TermGenie] +synonym: "up-regulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "up-regulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PR1-lysozyme" RELATED [GOC:TermGenie] +synonym: "upregulation of 1,4-N-acetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of globulin G" RELATED [GOC:TermGenie] +synonym: "upregulation of globulin G1" RELATED [GOC:TermGenie] +synonym: "upregulation of L-7001" RELATED [GOC:TermGenie] +synonym: "upregulation of lysozyme activity" EXACT [GOC:TermGenie] +synonym: "upregulation of lysozyme g" RELATED [GOC:TermGenie] +synonym: "upregulation of mucopeptide glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of mucopeptide N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of muramidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of N,O-diacetylmuramidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PR1-lysozyme" RELATED [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1903590 ! regulation of lysozyme activity + +[Term] +id: GO:1903593 +name: regulation of histamine secretion by mast cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] +is_a: GO:0043269 ! regulation of ion transport +is_a: GO:0046883 ! regulation of hormone secretion +is_a: GO:0050727 ! regulation of inflammatory response +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0002553 ! histamine secretion by mast cell + +[Term] +id: GO:1903594 +name: negative regulation of histamine secretion by mast cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] +synonym: "down regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +synonym: "downregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +synonym: "inhibition of histamine secretion by mast cell" NARROW [GOC:TermGenie] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0050728 ! negative regulation of inflammatory response +is_a: GO:1903593 ! regulation of histamine secretion by mast cell +relationship: negatively_regulates GO:0002553 ! histamine secretion by mast cell + +[Term] +id: GO:1903595 +name: positive regulation of histamine secretion by mast cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18253931] +synonym: "activation of histamine secretion by mast cell" NARROW [GOC:TermGenie] +synonym: "up regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +synonym: "upregulation of histamine secretion by mast cell" EXACT [GOC:TermGenie] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0043306 ! positive regulation of mast cell degranulation +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0050729 ! positive regulation of inflammatory response +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903593 ! regulation of histamine secretion by mast cell +relationship: positively_regulates GO:0002553 ! histamine secretion by mast cell + +[Term] +id: GO:1903596 +name: regulation of gap junction assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: regulates GO:0016264 ! gap junction assembly + +[Term] +id: GO:1903597 +name: negative regulation of gap junction assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] +synonym: "down regulation of gap junction assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of gap junction assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of gap junction assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of gap junction assembly" NARROW [GOC:TermGenie] +is_a: GO:1901889 ! negative regulation of cell junction assembly +is_a: GO:1903596 ! regulation of gap junction assembly +relationship: negatively_regulates GO:0016264 ! gap junction assembly + +[Term] +id: GO:1903598 +name: positive regulation of gap junction assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gap junction assembly." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:25017399] +synonym: "activation of gap junction assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of gap junction assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of gap junction assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of gap junction assembly" EXACT [GOC:TermGenie] +is_a: GO:1901890 ! positive regulation of cell junction assembly +is_a: GO:1903596 ! regulation of gap junction assembly +relationship: positively_regulates GO:0016264 ! gap junction assembly + +[Term] +id: GO:1903599 +name: positive regulation of autophagy of mitochondrion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy." [GO_REF:0000058, GOC:autophagy, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21753002] +comment: An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay +synonym: "activation of mitochondrion degradation" RELATED [GOC:TermGenie] +synonym: "activation of mitophagy" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial degradation" BROAD [GOC:TermGenie] +synonym: "up regulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "up regulation of mitophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "up-regulation of mitophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrion degradation" BROAD [GOC:TermGenie] +synonym: "upregulation of mitophagy" EXACT [GOC:TermGenie] +is_a: GO:0010508 ! positive regulation of autophagy +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:1903146 ! regulation of autophagy of mitochondrion +relationship: positively_regulates GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:1903600 +name: glutaminase complex +namespace: cellular_component +def: "A protein complex which is capable of glutaminase activity." [GO_REF:0000088, GOC:TermGenie, PMID:14764090] +synonym: "Sno1p-Snz1p" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1903601 +name: thermospermine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] +synonym: "thermospermine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006595 ! polyamine metabolic process + +[Term] +id: GO:1903602 +name: thermospermine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] +synonym: "thermospermine breakdown" EXACT [GOC:TermGenie] +synonym: "thermospermine catabolism" EXACT [GOC:TermGenie] +synonym: "thermospermine degradation" EXACT [GOC:TermGenie] +is_a: GO:0006598 ! polyamine catabolic process +is_a: GO:1903601 ! thermospermine metabolic process + +[Term] +id: GO:1903603 +name: thermospermine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of thermospermine." [GO_REF:0000068, GOC:TermGenie, PMID:24906355] +synonym: "thermospermine anabolism" EXACT [GOC:TermGenie] +synonym: "thermospermine biosynthesis" EXACT [GOC:TermGenie] +synonym: "thermospermine formation" EXACT [GOC:TermGenie] +synonym: "thermospermine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006596 ! polyamine biosynthetic process +is_a: GO:1903601 ! thermospermine metabolic process + +[Term] +id: GO:1903604 +name: cytochrome metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] +synonym: "cytochrome metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019538 ! protein metabolic process + +[Term] +id: GO:1903605 +name: cytochrome biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a cytochrome." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] +synonym: "cytochrome anabolism" EXACT [GOC:TermGenie] +synonym: "cytochrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "cytochrome formation" EXACT [GOC:TermGenie] +synonym: "cytochrome synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009059 ! macromolecule biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process +is_a: GO:1903604 ! cytochrome metabolic process + +[Term] +id: GO:1903606 +name: cytochrome c metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] +synonym: "cytochrome c metabolism" EXACT [GOC:TermGenie] +is_a: GO:1903604 ! cytochrome metabolic process + +[Term] +id: GO:1903607 +name: cytochrome c biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of cytochrome c." [GO_REF:0000068, GOC:dph, GOC:TermGenie, PMID:19721088] +synonym: "cytochrome c anabolism" EXACT [GOC:TermGenie] +synonym: "cytochrome c biosynthesis" EXACT [GOC:TermGenie] +synonym: "cytochrome c formation" EXACT [GOC:TermGenie] +synonym: "cytochrome c synthesis" EXACT [GOC:TermGenie] +is_a: GO:1903605 ! cytochrome biosynthetic process +is_a: GO:1903606 ! cytochrome c metabolic process + +[Term] +id: GO:1903608 +name: protein localization to cytoplasmic stress granule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] +synonym: "protein localisation in cytoplasmic stress granule" EXACT [GOC:TermGenie] +synonym: "protein localisation to cytoplasmic stress granule" EXACT [GOC:TermGenie] +synonym: "protein localization in cytoplasmic stress granule" EXACT [GOC:TermGenie] +synonym: "protein localization to stress granule" BROAD [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:1903609 +name: negative regulation of inward rectifier potassium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inward rectifier potassium channel activity." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18923542] +synonym: "down regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of inward rectifier potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Kir channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of inward rectifier potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Kir channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of Kir channel activity" EXACT [GOC:TermGenie] +is_a: GO:1901979 ! regulation of inward rectifier potassium channel activity +is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity + +[Term] +id: GO:1903610 +name: regulation of calcium-dependent ATPase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] +is_a: GO:0043462 ! regulation of ATP-dependent activity + +[Term] +id: GO:1903611 +name: negative regulation of calcium-dependent ATPase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] +synonym: "down regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium-dependent ATPase activity" NARROW [GOC:TermGenie] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity + +[Term] +id: GO:1903612 +name: positive regulation of calcium-dependent ATPase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium-dependent ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10861851] +synonym: "activation of calcium-dependent ATPase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-dependent ATPase activity" EXACT [GOC:TermGenie] +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:1903610 ! regulation of calcium-dependent ATPase activity + +[Term] +id: GO:1903613 +name: regulation of protein tyrosine phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] +synonym: "regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:1903614 +name: negative regulation of protein tyrosine phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] +synonym: "down regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PPT-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PTP-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PTPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity +is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity + +[Term] +id: GO:1903615 +name: positive regulation of protein tyrosine phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein tyrosine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11129957] +synonym: "activation of [phosphotyrosine]protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphoprotein phosphatase (phosphotyrosine) activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphotyrosine histone phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphotyrosine protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphotyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of PPT-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of protein phosphotyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of protein tyrosine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of protein-tyrosine-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of protein-tyrosine-phosphate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of PTP-phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of PTPase activity" NARROW [GOC:TermGenie] +synonym: "activation of tyrosine O-phosphate phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of tyrosylprotein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of [phosphotyrosine]protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphotyrosine histone phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphotyrosine protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphotyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PPT-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of protein phosphotyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of protein tyrosine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of protein-tyrosine-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of protein-tyrosine-phosphate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PTP-phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PTPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tyrosine O-phosphate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of tyrosylprotein phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity +is_a: GO:1903613 ! regulation of protein tyrosine phosphatase activity + +[Term] +id: GO:1903616 +name: obsolete MAPK cascade involved in axon regeneration +namespace: biological_process +def: "OBSOLETE. Any MAPK cascade that is involved in axon regeneration." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:19164707, PMID:19417215, PMID:19737525] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903617 +name: positive regulation of mitotic cytokinesis, site selection +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cytokinesis, site selection." [GO_REF:0000058, GOC:TermGenie, PMID:21246752] +is_a: GO:1902472 ! regulation of mitotic cytokinesis, site selection +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +is_a: GO:2000076 ! positive regulation of cytokinesis, site selection +relationship: positively_regulates GO:1902408 ! mitotic cytokinesis, site selection + +[Term] +id: GO:1903618 +name: regulation of transdifferentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0060290 ! transdifferentiation + +[Term] +id: GO:1903619 +name: negative regulation of transdifferentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] +synonym: "down regulation of transdifferentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of transdifferentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of transdifferentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of transdifferentiation" NARROW [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1903618 ! regulation of transdifferentiation +relationship: negatively_regulates GO:0060290 ! transdifferentiation + +[Term] +id: GO:1903620 +name: positive regulation of transdifferentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transdifferentiation." [GO_REF:0000058, GOC:TermGenie, PMID:22118091] +synonym: "activation of transdifferentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of transdifferentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of transdifferentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of transdifferentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1903618 ! regulation of transdifferentiation +relationship: positively_regulates GO:0060290 ! transdifferentiation + +[Term] +id: GO:1903621 +name: protein localization to photoreceptor connecting cilium +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a photoreceptor connecting cilium." [GO_REF:0000087, GOC:lb, GOC:TermGenie, PMID:25398945] +synonym: "protein localisation in photoreceptor connecting cilium" EXACT [GOC:TermGenie] +synonym: "protein localisation to photoreceptor connecting cilium" EXACT [GOC:TermGenie] +synonym: "protein localization in photoreceptor connecting cilium" EXACT [GOC:TermGenie] +is_a: GO:0097499 ! protein localization to non-motile cilium +is_a: GO:1904491 ! protein localization to ciliary transition zone + +[Term] +id: GO:1903622 +name: regulation of RNA polymerase III activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932] +synonym: "regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +is_a: GO:0006359 ! regulation of transcription by RNA polymerase III +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1903623 +name: negative regulation of RNA polymerase III activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity." [GO_REF:0000059, GOC:TermGenie, PMID:25392932] +synonym: "down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA polymerase III activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA polymerase III activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA polymerase III activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA polymerase III activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [GOC:TermGenie] +is_a: GO:0016480 ! negative regulation of transcription by RNA polymerase III +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1903622 ! regulation of RNA polymerase III activity + +[Term] +id: GO:1903624 +name: regulation of DNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] +synonym: "regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of DNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0006308 ! DNA catabolic process + +[Term] +id: GO:1903625 +name: negative regulation of DNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] +synonym: "down regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of DNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:1903624 ! regulation of DNA catabolic process +relationship: negatively_regulates GO:0006308 ! DNA catabolic process + +[Term] +id: GO:1903626 +name: positive regulation of DNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:2001740] +synonym: "activation of DNA breakdown" NARROW [GOC:TermGenie] +synonym: "activation of DNA catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of DNA catabolism" NARROW [GOC:TermGenie] +synonym: "activation of DNA degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA degradation" EXACT [GOC:TermGenie] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:1903624 ! regulation of DNA catabolic process +relationship: positively_regulates GO:0006308 ! DNA catabolic process + +[Term] +id: GO:1903627 +name: regulation of dUTP diphosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] +synonym: "regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of dUTPase activity" EXACT [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1903628 +name: negative regulation of dUTP diphosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] +synonym: "down regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of dUTP diphosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of dUTPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of dUTPase activity" EXACT [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:1903627 ! regulation of dUTP diphosphatase activity + +[Term] +id: GO:1903629 +name: positive regulation of dUTP diphosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dUTP diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1315924] +synonym: "activation of deoxyuridine-triphosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of desoxyuridine 5'-triphosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of dUTP diphosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of dUTP nucleotidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of dUTP pyrophosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of dUTPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of dUTPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyuridine-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of desoxyuridine 5'-triphosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of dUTP diphosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of dUTP nucleotidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of dUTP pyrophosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of dUTPase activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1903627 ! regulation of dUTP diphosphatase activity + +[Term] +id: GO:1903630 +name: regulation of aminoacyl-tRNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:1903631 +name: negative regulation of aminoacyl-tRNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "down regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "downregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "inhibition of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +is_a: GO:0051352 ! negative regulation of ligase activity +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1903632 +name: positive regulation of aminoacyl-tRNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aminoacyl-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "activation of aminoacyl-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of aminoacyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "up regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +synonym: "upregulation of aminoacyl-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aminoacyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [GOC:TermGenie] +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1903633 +name: regulation of leucine-tRNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1903634 +name: negative regulation of leucine-tRNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "down regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of leucine translase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity +is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity + +[Term] +id: GO:1903635 +name: positive regulation of leucine-tRNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:2280766] +synonym: "activation of L-leucine:tRNALeu ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "activation of leucine translase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucine-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of leucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-leucine:tRNALeu ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of leucine translase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of leucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity +is_a: GO:1903633 ! regulation of leucine-tRNA ligase activity + +[Term] +id: GO:1903636 +name: regulation of protein insertion into mitochondrial outer membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] +synonym: "regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "regulation of protein import into mitochondrial outer membrane" EXACT [] +synonym: "regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +is_a: GO:0010821 ! regulation of mitochondrion organization +is_a: GO:1903214 ! regulation of protein targeting to mitochondrion +is_a: GO:1904589 ! regulation of protein import +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0045040 ! protein insertion into mitochondrial outer membrane + +[Term] +id: GO:1903637 +name: negative regulation of protein insertion into mitochondrial outer membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] +synonym: "down regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "down regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "downregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie] +synonym: "inhibition of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein import into mitochondrial outer membrane" EXACT [] +synonym: "negative regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:1903215 ! negative regulation of protein targeting to mitochondrion +is_a: GO:1903636 ! regulation of protein insertion into mitochondrial outer membrane +is_a: GO:1904590 ! negative regulation of protein import +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane + +[Term] +id: GO:1903638 +name: positive regulation of protein insertion into mitochondrial outer membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane." [GO_REF:0000058, GOC:TermGenie, PMID:16374546] +synonym: "activation of mitochondrial outer membrane protein import" NARROW [GOC:TermGenie] +synonym: "activation of protein import into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein insertion into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein transport into mitochondrial outer membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein import into mitochondrial outer membrane" EXACT [] +synonym: "positive regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "up regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial outer membrane protein import" EXACT [GOC:TermGenie] +synonym: "upregulation of protein import into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein insertion into mitochondrial outer membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein transport into mitochondrial outer membrane" EXACT [GOC:TermGenie] +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:1903636 ! regulation of protein insertion into mitochondrial outer membrane +is_a: GO:1903955 ! positive regulation of protein targeting to mitochondrion +is_a: GO:1904591 ! positive regulation of protein import +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:0045040 ! protein insertion into mitochondrial outer membrane + +[Term] +id: GO:1903639 +name: regulation of gastrin-induced gastric acid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] +is_a: GO:0060453 ! regulation of gastric acid secretion +relationship: regulates GO:0001698 ! gastrin-induced gastric acid secretion + +[Term] +id: GO:1903640 +name: negative regulation of gastrin-induced gastric acid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] +synonym: "down regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie] +is_a: GO:0060455 ! negative regulation of gastric acid secretion +is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion +relationship: negatively_regulates GO:0001698 ! gastrin-induced gastric acid secretion + +[Term] +id: GO:1903641 +name: positive regulation of gastrin-induced gastric acid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gastrin-induced gastric acid secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11123201] +synonym: "activation of gastrin-induced gastric acid secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of gastrin-induced gastric acid secretion" EXACT [GOC:TermGenie] +is_a: GO:0060454 ! positive regulation of gastric acid secretion +is_a: GO:1903639 ! regulation of gastrin-induced gastric acid secretion +relationship: positively_regulates GO:0001698 ! gastrin-induced gastric acid secretion + +[Term] +id: GO:1903642 +name: regulation of recombination hotspot binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749] +synonym: "regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:1903643 +name: positive regulation of recombination hotspot binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of recombination hotspot binding." [GO_REF:0000059, GOC:TermGenie, PMID:19436749] +synonym: "activation of DNA binding, recombination hotspot" NARROW [GOC:TermGenie] +synonym: "activation of recombination hotspot binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] +synonym: "up regulation of recombination hotspot binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] +synonym: "up-regulation of recombination hotspot binding" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA binding, recombination hotspot" EXACT [GOC:TermGenie] +synonym: "upregulation of recombination hotspot binding" EXACT [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:1903642 ! regulation of recombination hotspot binding + +[Term] +id: GO:1903644 +name: regulation of chaperone-mediated protein folding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] +is_a: GO:1903332 ! regulation of protein folding +relationship: regulates GO:0061077 ! chaperone-mediated protein folding + +[Term] +id: GO:1903645 +name: negative regulation of chaperone-mediated protein folding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] +synonym: "down regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +synonym: "down-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +synonym: "downregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +synonym: "inhibition of chaperone-mediated protein folding" NARROW [GOC:TermGenie] +is_a: GO:1903333 ! negative regulation of protein folding +is_a: GO:1903644 ! regulation of chaperone-mediated protein folding +relationship: negatively_regulates GO:0061077 ! chaperone-mediated protein folding + +[Term] +id: GO:1903646 +name: positive regulation of chaperone-mediated protein folding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding." [GO_REF:0000058, GOC:TermGenie, PMID:24375412] +synonym: "activation of chaperone-mediated protein folding" NARROW [GOC:TermGenie] +synonym: "up regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +synonym: "up-regulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +synonym: "upregulation of chaperone-mediated protein folding" EXACT [GOC:TermGenie] +is_a: GO:1903334 ! positive regulation of protein folding +is_a: GO:1903644 ! regulation of chaperone-mediated protein folding +relationship: positively_regulates GO:0061077 ! chaperone-mediated protein folding + +[Term] +id: GO:1903647 +name: negative regulation of chlorophyll catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469] +synonym: "down regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of chlorophyll breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of chlorophyll degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +is_a: GO:0010271 ! regulation of chlorophyll catabolic process +is_a: GO:1901405 ! negative regulation of tetrapyrrole catabolic process +relationship: negatively_regulates GO:0015996 ! chlorophyll catabolic process + +[Term] +id: GO:1903648 +name: positive regulation of chlorophyll catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chlorophyll catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:24719469] +synonym: "activation of chlorophyll breakdown" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll catabolism" NARROW [GOC:TermGenie] +synonym: "activation of chlorophyll degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of chlorophyll degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of chlorophyll degradation" EXACT [GOC:TermGenie] +is_a: GO:0010271 ! regulation of chlorophyll catabolic process +is_a: GO:1901406 ! positive regulation of tetrapyrrole catabolic process +relationship: positively_regulates GO:0015996 ! chlorophyll catabolic process + +[Term] +id: GO:1903649 +name: regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +relationship: regulates GO:0016482 ! cytosolic transport + +[Term] +id: GO:1903650 +name: negative regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: negatively_regulates GO:0016482 ! cytosolic transport + +[Term] +id: GO:1903651 +name: positive regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: positively_regulates GO:0016482 ! cytosolic transport + +[Term] +id: GO:1903652 +name: modulation by virus of host cytoplasmic transport +namespace: biological_process +def: "Modulation by an infecting virus of host cytoplasmic transport." [GO_REF:0000063, GOC:TermGenie, PMID:25049409] +synonym: "regulation by virus of host cytoplasmic streaming" EXACT [] +synonym: "regulation by virus of host cytoplasmic transport" EXACT [] +synonym: "viral modulation of host cytoplasmic trafficking" EXACT [] +is_a: GO:0019054 ! modulation by virus of host cellular process +relationship: regulates GO:0016482 ! cytosolic transport + +[Term] +id: GO:1903653 +name: modulation by symbiont of host cell motility +namespace: biological_process +def: "Modulation of host cell motility by a symbiont of that host." [GO_REF:0000063, GOC:TermGenie, PMID:25049409] +synonym: "modulation by symbiont of host cell locomotion" EXACT [] +synonym: "modulation by symbiont of host cell movement" RELATED [] +synonym: "regulation by symbiont of host cell motility" EXACT [] +is_a: GO:0044068 ! modulation by symbiont of host cellular process +relationship: regulates GO:0048870 ! cell motility + +[Term] +id: GO:1903654 +name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter +namespace: biological_process +def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 5 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067] +is_a: GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues +relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:1903655 +name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter +namespace: biological_process +def: "Any phosphorylation of RNA polymerase II C-terminal domain serine 2 residues that is involved in positive regulation of transcription elongation from RNA polymerase II promoter." [GO_REF:0000060, GOC:TermGenie, PMID:19328067] +is_a: GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +relationship: part_of GO:0032968 ! positive regulation of transcription elongation from RNA polymerase II promoter + +[Term] +id: GO:1903656 +name: regulation of type IV pilus biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0060491 ! regulation of cell projection assembly +relationship: regulates GO:0043683 ! type IV pilus assembly + +[Term] +id: GO:1903657 +name: negative regulation of type IV pilus biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "down regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of TFP biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type 4 pilus biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbria assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbria biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbriae assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbriae biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbrial assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbrial biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbrium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV fimbrium biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV pilus biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of type IV pilus biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:1903656 ! regulation of type IV pilus biogenesis +relationship: negatively_regulates GO:0043683 ! type IV pilus assembly + +[Term] +id: GO:1903658 +name: positive regulation of type IV pilus biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type IV pilus biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "activation of TFP biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type 4 pilus biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbria assembly" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbria biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbriae assembly" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbriae biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbrial assembly" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbrial biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbrium assembly" NARROW [GOC:TermGenie] +synonym: "activation of type IV fimbrium biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV pilus biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of type IV pilus biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of TFP biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type 4 pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbria assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbria biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbriae assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbriae biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbrial assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbrial biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbrium assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV fimbrium biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV pilus biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of type IV pilus biosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:1903656 ! regulation of type IV pilus biogenesis +relationship: positively_regulates GO:0043683 ! type IV pilus assembly + +[Term] +id: GO:1903659 +name: regulation of complement-dependent cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] +is_a: GO:0031341 ! regulation of cell killing +relationship: regulates GO:0097278 ! complement-dependent cytotoxicity + +[Term] +id: GO:1903660 +name: negative regulation of complement-dependent cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] +synonym: "down regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +synonym: "down-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +synonym: "downregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +synonym: "inhibition of complement-dependent cytotoxicity" NARROW [GOC:TermGenie] +is_a: GO:0031342 ! negative regulation of cell killing +is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity +relationship: negatively_regulates GO:0097278 ! complement-dependent cytotoxicity + +[Term] +id: GO:1903661 +name: positive regulation of complement-dependent cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of complement-dependent cytotoxicity." [GO_REF:0000058, GOC:TermGenie, PMID:24280217] +synonym: "activation of complement-dependent cytotoxicity" NARROW [GOC:TermGenie] +synonym: "up regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +synonym: "up-regulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +synonym: "upregulation of complement-dependent cytotoxicity" EXACT [GOC:TermGenie] +is_a: GO:0031343 ! positive regulation of cell killing +is_a: GO:1903659 ! regulation of complement-dependent cytotoxicity +relationship: positively_regulates GO:0097278 ! complement-dependent cytotoxicity + +[Term] +id: GO:1903662 +name: L-altrarate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980] +synonym: "L-altrarate(1-) metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019577 ! aldaric acid metabolic process + +[Term] +id: GO:1903663 +name: L-altrarate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of L-altrarate." [GO_REF:0000068, GOC:TermGenie, PMID:17649980] +synonym: "L-altrarate(1-) breakdown" EXACT [GOC:TermGenie] +synonym: "L-altrarate(1-) catabolism" EXACT [GOC:TermGenie] +synonym: "L-altrarate(1-) degradation" EXACT [GOC:TermGenie] +is_a: GO:0019579 ! aldaric acid catabolic process +is_a: GO:1903662 ! L-altrarate metabolic process + +[Term] +id: GO:1903664 +name: regulation of asexual reproduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0019954 ! asexual reproduction + +[Term] +id: GO:1903665 +name: negative regulation of asexual reproduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] +synonym: "down regulation of asexual reproduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of asexual reproduction" EXACT [GOC:TermGenie] +synonym: "downregulation of asexual reproduction" EXACT [GOC:TermGenie] +synonym: "inhibition of asexual reproduction" NARROW [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1903664 ! regulation of asexual reproduction +relationship: negatively_regulates GO:0019954 ! asexual reproduction + +[Term] +id: GO:1903666 +name: positive regulation of asexual reproduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asexual reproduction." [GO_REF:0000058, GOC:TermGenie, PMID:24390142] +synonym: "activation of asexual reproduction" NARROW [GOC:TermGenie] +synonym: "up regulation of asexual reproduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of asexual reproduction" EXACT [GOC:TermGenie] +synonym: "upregulation of asexual reproduction" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1903664 ! regulation of asexual reproduction +relationship: positively_regulates GO:0019954 ! asexual reproduction + +[Term] +id: GO:1903667 +name: regulation of chemorepellent activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] +synonym: "regulation of chemorepellant activity" EXACT [GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:0050923 ! regulation of negative chemotaxis +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1903668 +name: negative regulation of chemorepellent activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] +synonym: "down regulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "down regulation of chemorepellent activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemorepellent activity" EXACT [GOC:TermGenie] +synonym: "downregulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "downregulation of chemorepellent activity" EXACT [GOC:TermGenie] +synonym: "inhibition of chemorepellant activity" NARROW [GOC:TermGenie] +synonym: "inhibition of chemorepellent activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of chemorepellant activity" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050925 ! negative regulation of negative chemotaxis +is_a: GO:1900121 ! negative regulation of receptor binding +is_a: GO:1903667 ! regulation of chemorepellent activity + +[Term] +id: GO:1903669 +name: positive regulation of chemorepellent activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemorepellent activity." [GO_REF:0000059, GOC:TermGenie, PMID:22711818, PMID:24390142] +synonym: "activation of chemorepellant activity" NARROW [GOC:TermGenie] +synonym: "activation of chemorepellent activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "up regulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "up regulation of chemorepellent activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of chemorepellent activity" EXACT [GOC:TermGenie] +synonym: "upregulation of chemorepellant activity" EXACT [GOC:TermGenie] +synonym: "upregulation of chemorepellent activity" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:1903667 ! regulation of chemorepellent activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1903670 +name: regulation of sprouting angiogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] +is_a: GO:0045765 ! regulation of angiogenesis +relationship: regulates GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:1903671 +name: negative regulation of sprouting angiogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] +synonym: "down regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of sprouting angiogenesis" NARROW [GOC:TermGenie] +is_a: GO:0016525 ! negative regulation of angiogenesis +is_a: GO:1903670 ! regulation of sprouting angiogenesis +relationship: negatively_regulates GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:1903672 +name: positive regulation of sprouting angiogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:16756958] +synonym: "activation of sprouting angiogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of sprouting angiogenesis" EXACT [GOC:TermGenie] +is_a: GO:0045766 ! positive regulation of angiogenesis +is_a: GO:1903670 ! regulation of sprouting angiogenesis +relationship: positively_regulates GO:0002040 ! sprouting angiogenesis + +[Term] +id: GO:1903673 +name: mitotic cleavage furrow formation +namespace: biological_process +def: "Any cleavage furrow formation that is involved in mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +synonym: "cleavage furrow positioning involved in mitotic cell cycle" NARROW [GOC:TermGenie] +is_a: GO:0036089 ! cleavage furrow formation +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1903674 +name: regulation of cap-dependent translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +relationship: regulates GO:0002191 ! cap-dependent translational initiation + +[Term] +id: GO:1903675 +name: negative regulation of cap-dependent translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +synonym: "inhibition of cap-dependent translational initiation" NARROW [GOC:TermGenie] +is_a: GO:1903674 ! regulation of cap-dependent translational initiation +is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation +relationship: negatively_regulates GO:0002191 ! cap-dependent translational initiation + +[Term] +id: GO:1903676 +name: positive regulation of cap-dependent translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995] +synonym: "activation of cap-dependent translational initiation" NARROW [GOC:TermGenie] +synonym: "up regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cap-dependent translational initiation" EXACT [GOC:TermGenie] +is_a: GO:1903674 ! regulation of cap-dependent translational initiation +is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation +relationship: positively_regulates GO:0002191 ! cap-dependent translational initiation + +[Term] +id: GO:1903677 +name: regulation of cap-independent translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +relationship: regulates GO:0002190 ! cap-independent translational initiation + +[Term] +id: GO:1903678 +name: negative regulation of cap-independent translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +synonym: "inhibition of cap-independent translational initiation" NARROW [GOC:TermGenie] +is_a: GO:1903677 ! regulation of cap-independent translational initiation +is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation +relationship: negatively_regulates GO:0002190 ! cap-independent translational initiation + +[Term] +id: GO:1903679 +name: positive regulation of cap-independent translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11959995] +synonym: "activation of cap-independent translational initiation" NARROW [GOC:TermGenie] +synonym: "up regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cap-independent translational initiation" EXACT [GOC:TermGenie] +is_a: GO:1903677 ! regulation of cap-independent translational initiation +is_a: GO:1904690 ! positive regulation of cytoplasmic translational initiation +relationship: positively_regulates GO:0002190 ! cap-independent translational initiation + +[Term] +id: GO:1903680 +name: acinar cell of sebaceous gland differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an acinar cell of sebaceous gland." [GO_REF:0000086, GOC:TermGenie, PMID:17018284, PMID:18334552, PMID:19944183] +synonym: "sebocyte differentiation" EXACT [CL:0002140] +is_a: GO:0001949 ! sebaceous gland cell differentiation +is_a: GO:0090425 ! acinar cell differentiation + +[Term] +id: GO:1903681 +name: regulation of epithelial cell-cell adhesion involved in epithelium migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +is_a: GO:0022407 ! regulation of cell-cell adhesion +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration + +[Term] +id: GO:1903682 +name: negative regulation of epithelial cell-cell adhesion involved in epithelium migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "down regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration +relationship: negatively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration + +[Term] +id: GO:1903683 +name: positive regulation of epithelial cell-cell adhesion involved in epithelium migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "activation of epithelial cell-cell adhesion involved in epithelium migration" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial cell-cell adhesion involved in epithelium migration" EXACT [GOC:TermGenie] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903681 ! regulation of epithelial cell-cell adhesion involved in epithelium migration +relationship: positively_regulates GO:0090137 ! epithelial cell-cell adhesion involved in epithelium migration + +[Term] +id: GO:1903684 +name: regulation of border follicle cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "regulation of border cell migration" BROAD [GOC:TermGenie] +is_a: GO:0010632 ! regulation of epithelial cell migration +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007298 ! border follicle cell migration + +[Term] +id: GO:1903687 +name: negative regulation of border follicle cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "inhibition of border follicle cell migration" NARROW [GOC:TermGenie] +is_a: GO:0010633 ! negative regulation of epithelial cell migration +is_a: GO:1903684 ! regulation of border follicle cell migration +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0007298 ! border follicle cell migration + +[Term] +id: GO:1903688 +name: positive regulation of border follicle cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of border follicle cell migration." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "activation of border follicle cell migration" NARROW [GOC:TermGenie] +is_a: GO:0010634 ! positive regulation of epithelial cell migration +is_a: GO:1903684 ! regulation of border follicle cell migration +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0007298 ! border follicle cell migration + +[Term] +id: GO:1903689 +name: regulation of wound healing, spreading of epidermal cells +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0061041 ! regulation of wound healing +relationship: regulates GO:0035313 ! wound healing, spreading of epidermal cells + +[Term] +id: GO:1903690 +name: negative regulation of wound healing, spreading of epidermal cells +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "down regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +synonym: "down-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +synonym: "downregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +synonym: "inhibition of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0061045 ! negative regulation of wound healing +is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells +relationship: negatively_regulates GO:0035313 ! wound healing, spreading of epidermal cells + +[Term] +id: GO:1903691 +name: positive regulation of wound healing, spreading of epidermal cells +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18394891] +synonym: "activation of wound healing, spreading of epidermal cells" NARROW [GOC:TermGenie] +synonym: "up regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +synonym: "up-regulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +synonym: "upregulation of wound healing, spreading of epidermal cells" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0090303 ! positive regulation of wound healing +is_a: GO:1903689 ! regulation of wound healing, spreading of epidermal cells +relationship: positively_regulates GO:0035313 ! wound healing, spreading of epidermal cells + +[Term] +id: GO:1903692 +name: methionine import across plasma membrane +namespace: biological_process +alt_id: GO:0044690 +def: "The directed movement of methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] +synonym: "methionine import" BROAD [] +synonym: "methionine import into cell" EXACT [] +is_a: GO:0015821 ! methionine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1903693 +name: obsolete regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656] +comment: This term was obsoleted because it does not represent a specific process. +synonym: "regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903694 +name: obsolete positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation." [GO_REF:0000058, GOC:TermGenie, PMID:15713656] +comment: This term was obsoleted because it does not represent a specific process. +synonym: "activation of G1 mitotic cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie] +synonym: "activation of mitotic G1 cell cycle arrest in response to nitrogen starvation" NARROW [GOC:TermGenie] +synonym: "positive regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "up regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "up-regulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "upregulation of G1 mitotic cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic G1 cell cycle arrest in response to nitrogen starvation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903695 +name: obsolete MAPK cascade involved in ascospore formation +namespace: biological_process +def: "OBSOLETE. Any MAPK cascade that is involved in ascospore formation." [GO_REF:0000060, GOC:TermGenie, PMID:8443406] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "ERK/MAPK cascade involved in ascospore biosynthesis" NARROW [GOC:TermGenie] +synonym: "ERK/MAPK cascade involved in ascospore formation" NARROW [GOC:TermGenie] +synonym: "MAP kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "MAP kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "MAP kinase kinase kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "MAP kinase kinase kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "MAPK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "MAPK signal transduction involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "MAPK signal transduction involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "MAPK signaling involved in ascospore biosynthesis" RELATED [GOC:TermGenie] +synonym: "MAPK signaling involved in ascospore formation" RELATED [GOC:TermGenie] +synonym: "MAPK signalling involved in ascospore biosynthesis" RELATED [GOC:TermGenie] +synonym: "MAPK signalling involved in ascospore formation" RELATED [GOC:TermGenie] +synonym: "MAPKKK cascade during sporulation involved in ascospore biosynthesis" NARROW [GOC:TermGenie] +synonym: "MAPKKK cascade during sporulation involved in ascospore formation" NARROW [GOC:TermGenie] +synonym: "MAPKKK cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "MAPKKK cascade involved in ascospore formation" EXACT [GOC:TermGenie] +synonym: "mitogen-activated protein kinase cascade involved in ascospore biosynthesis" EXACT [GOC:TermGenie] +synonym: "mitogen-activated protein kinase cascade involved in ascospore formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903696 +name: protein localization to horsetail-astral microtubule array +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array." [GO_REF:0000087, GOC:TermGenie, PMID:11907273] +synonym: "protein localisation in horsetail-astral microtubule array" EXACT [GOC:TermGenie] +synonym: "protein localisation to horsetail-astral microtubule array" EXACT [GOC:TermGenie] +synonym: "protein localization in horsetail-astral microtubule array" EXACT [GOC:TermGenie] +is_a: GO:0072699 ! protein localization to cortical microtubule cytoskeleton + +[Term] +id: GO:1903697 +name: negative regulation of microvillus assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] +synonym: "down regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of microvillus assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0032534 ! regulation of microvillus assembly +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +relationship: negatively_regulates GO:0030033 ! microvillus assembly + +[Term] +id: GO:1903698 +name: positive regulation of microvillus assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microvillus assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:22797597] +synonym: "activation of microvillus assembly" NARROW [GOC:TermGenie] +synonym: "activation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of microvillus biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of microvillus assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of microvillus biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0032534 ! regulation of microvillus assembly +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +relationship: positively_regulates GO:0030033 ! microvillus assembly + +[Term] +id: GO:1903699 +name: tarsal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of a tarsal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:20664693] +synonym: "gland of Meibom development" EXACT [GOC:TermGenie] +synonym: "glandula tarsales development" EXACT [GOC:TermGenie] +synonym: "Meibomian gland development" EXACT [GOC:TermGenie] +synonym: "tarsoconjunctival gland development" RELATED [GOC:TermGenie] +is_a: GO:0048733 ! sebaceous gland development + +[Term] +id: GO:1903700 +name: caecum development +namespace: biological_process +def: "The process whose specific outcome is the progression of a caecum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] +synonym: "blind intestine development" RELATED [GOC:TermGenie] +synonym: "blindgut development" RELATED [GOC:TermGenie] +synonym: "caeca development" NARROW [GOC:TermGenie] +synonym: "ceca development" NARROW [GOC:TermGenie] +synonym: "cecum development" EXACT [GOC:TermGenie] +synonym: "intestinum caecum development" RELATED [GOC:TermGenie] +synonym: "intestinum crassum caecum development" EXACT [GOC:TermGenie] +synonym: "intestinum crassum cecum development" RELATED [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1903701 +name: substantia propria of cornea development +namespace: biological_process +def: "The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12556382] +synonym: "corneal stroma development" EXACT [GOC:TermGenie] +synonym: "stroma of cornea development" EXACT [GOC:TermGenie] +synonym: "substantia propria development" RELATED [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1903702 +name: esophagus development +namespace: biological_process +def: "The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0-683-40008-8] +synonym: "esophageal development" EXACT [MGI:csmith] +synonym: "gullet development" EXACT [GOC:TermGenie] +synonym: "oesophagus development" EXACT [GOC:TermGenie] +is_a: GO:0048513 ! animal organ development + +[Term] +id: GO:1903703 +name: enterocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of an enterocyte." [GO_REF:0000086, GOC:TermGenie, PMID:16782882, Wikipedia:List_of_intestinal_epithelial_differentiation_genes] +is_a: GO:0060575 ! intestinal epithelial cell differentiation + +[Term] +id: GO:1903704 +name: negative regulation of production of siRNA involved in RNA interference +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182] +synonym: "down regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "down regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "down-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "downregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "inhibition of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie] +synonym: "inhibition of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA interference, production of siRNA" NARROW [GOC:TermGenie] +synonym: "negative regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference +is_a: GO:1900369 ! negative regulation of RNA interference +relationship: negatively_regulates GO:0030422 ! production of siRNA involved in RNA interference + +[Term] +id: GO:1903705 +name: positive regulation of production of siRNA involved in RNA interference +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of production of siRNA involved in RNA interference." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19701182] +synonym: "activation of production of guide RNAs involved in RNA interference" NARROW [GOC:TermGenie] +synonym: "activation of production of siRNA involved in RNA interference" NARROW [GOC:TermGenie] +synonym: "activation of RNA interference, production of guide RNAs" NARROW [GOC:TermGenie] +synonym: "activation of RNA interference, production of siRNA" NARROW [GOC:TermGenie] +synonym: "positive regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "up regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "up-regulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of production of guide RNAs involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "upregulation of production of siRNA involved in RNA interference" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA interference, production of guide RNAs" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA interference, production of siRNA" EXACT [GOC:TermGenie] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:0090065 ! regulation of production of siRNA involved in RNA interference +relationship: positively_regulates GO:0030422 ! production of siRNA involved in RNA interference + +[Term] +id: GO:1903706 +name: regulation of hemopoiesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] +comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. +synonym: "regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "regulation of hematopoiesis" EXACT [GOC:TermGenie] +is_a: GO:0002682 ! regulation of immune system process +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0030097 ! hemopoiesis + +[Term] +id: GO:1903707 +name: negative regulation of hemopoiesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] +comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. +synonym: "down regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "down regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hemopoiesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hemopoiesis" EXACT [GOC:TermGenie] +synonym: "downregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "downregulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hemopoiesis" EXACT [GOC:TermGenie] +synonym: "inhibition of blood cell biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of blood cell formation" NARROW [GOC:TermGenie] +synonym: "inhibition of haemopoiesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hematopoiesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hemopoiesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hematopoiesis" EXACT [GOC:TermGenie] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903706 ! regulation of hemopoiesis +relationship: negatively_regulates GO:0030097 ! hemopoiesis + +[Term] +id: GO:1903708 +name: positive regulation of hemopoiesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hemopoiesis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20080761] +comment: An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. +synonym: "activation of blood cell biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of blood cell formation" NARROW [GOC:TermGenie] +synonym: "activation of haemopoiesis" NARROW [GOC:TermGenie] +synonym: "activation of hematopoiesis" NARROW [GOC:TermGenie] +synonym: "activation of hemopoiesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "up regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "up regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hemopoiesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hemopoiesis" EXACT [GOC:TermGenie] +synonym: "upregulation of blood cell biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of blood cell formation" EXACT [GOC:TermGenie] +synonym: "upregulation of haemopoiesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hematopoiesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hemopoiesis" EXACT [GOC:TermGenie] +is_a: GO:0002684 ! positive regulation of immune system process +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903706 ! regulation of hemopoiesis +relationship: positively_regulates GO:0030097 ! hemopoiesis + +[Term] +id: GO:1903709 +name: uterine gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:23619340] +synonym: "endometrial gland development" EXACT [GOC:TermGenie] +synonym: "endometrium gland development" EXACT [GOC:TermGenie] +synonym: "glandulae uterinae development" RELATED [GOC:TermGenie] +synonym: "glandular part of endometrium development" RELATED [GOC:TermGenie] +synonym: "set of uterine glands development" RELATED [GOC:TermGenie] +synonym: "uterine glands development" EXACT [GOC:TermGenie] +synonym: "uterine glands set development" EXACT [GOC:TermGenie] +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0048732 ! gland development + +[Term] +id: GO:1903710 +name: spermine transmembrane transport +namespace: biological_process +def: "The process in which spermine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075] +is_a: GO:0000296 ! spermine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:1902047 ! polyamine transmembrane transport + +[Term] +id: GO:1903711 +name: spermidine transmembrane transport +namespace: biological_process +def: "The process in which spermidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:15637075] +is_a: GO:0015848 ! spermidine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:1902047 ! polyamine transmembrane transport + +[Term] +id: GO:1903712 +name: cysteine transmembrane transport +namespace: biological_process +def: "The directed movement of cysteine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:17435223] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0042883 ! cysteine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1903713 +name: asparagine transmembrane transport +namespace: biological_process +def: "The directed movement of asparagine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0042886 ! amide transport + +[Term] +id: GO:1903714 +name: isoleucine transmembrane transport +namespace: biological_process +def: "The directed movement of isoleucine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18503766] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0015818 ! isoleucine transport + +[Term] +id: GO:1903715 +name: regulation of aerobic respiration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aerobic respiration." [GO_REF:0000058, GOC:TermGenie, PMID:19266076] +is_a: GO:0043457 ! regulation of cellular respiration +relationship: regulates GO:0009060 ! aerobic respiration + +[Term] +id: GO:1903716 +name: guanine transmembrane transport +namespace: biological_process +def: "The process in which guanine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:14998997] +is_a: GO:0015854 ! guanine transport +is_a: GO:1904823 ! purine nucleobase transmembrane transport + +[Term] +id: GO:1903719 +name: regulation of I-kappaB phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531] +synonym: "regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0007252 ! I-kappaB phosphorylation + +[Term] +id: GO:1903720 +name: negative regulation of I-kappaB phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531] +synonym: "down regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "inhibition of I-kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of IkappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of IKB phosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "inhibition of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:1903719 ! regulation of I-kappaB phosphorylation +relationship: negatively_regulates GO:0007252 ! I-kappaB phosphorylation + +[Term] +id: GO:1903721 +name: positive regulation of I-kappaB phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:23675531] +synonym: "activation of I-kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of IkappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of IKB phosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of inhibitor of kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of inhibitor of NF-kappaB phosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of I-kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of IkappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of IKB phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibitor of kappaB phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibitor of NF-kappaB phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:1903719 ! regulation of I-kappaB phosphorylation +relationship: positively_regulates GO:0007252 ! I-kappaB phosphorylation + +[Term] +id: GO:1903722 +name: regulation of centriole elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0061511 ! centriole elongation + +[Term] +id: GO:1903723 +name: negative regulation of centriole elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] +synonym: "down regulation of centriole elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of centriole elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of centriole elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of centriole elongation" NARROW [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:1903722 ! regulation of centriole elongation +relationship: negatively_regulates GO:0061511 ! centriole elongation + +[Term] +id: GO:1903724 +name: positive regulation of centriole elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of centriole elongation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:20616062] +synonym: "activation of centriole elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of centriole elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of centriole elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of centriole elongation" EXACT [GOC:TermGenie] +is_a: GO:0046601 ! positive regulation of centriole replication +is_a: GO:1903722 ! regulation of centriole elongation +relationship: positively_regulates GO:0061511 ! centriole elongation + +[Term] +id: GO:1903725 +name: regulation of phospholipid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] +synonym: "regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0019220 ! regulation of phosphate metabolic process +relationship: regulates GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:1903726 +name: negative regulation of phospholipid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] +synonym: "down regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of phospholipid metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of phospholipid metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045833 ! negative regulation of lipid metabolic process +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: negatively_regulates GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:1903727 +name: positive regulation of phospholipid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10657240] +synonym: "activation of phospholipid metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of phospholipid metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipid metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipid metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045834 ! positive regulation of lipid metabolic process +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +is_a: GO:1903725 ! regulation of phospholipid metabolic process +relationship: positively_regulates GO:0006644 ! phospholipid metabolic process + +[Term] +id: GO:1903728 +name: luteal cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." [GO_REF:0000086, GOC:TermGenie, MP:0001133] +synonym: "lutein cell differentiation" EXACT [CL:0000175] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:1903729 +name: regulation of plasma membrane organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasma membrane organization." [GO_REF:0000058, GOC:TermGenie, PMID:24514900] +synonym: "regulation of plasma membrane organisation" EXACT [GOC:TermGenie] +synonym: "regulation of plasma membrane organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0007009 ! plasma membrane organization + +[Term] +id: GO:1903730 +name: regulation of phosphatidate phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22334681, PMID:24876385, PMID:25359770] +comment: Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity +synonym: "regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0010921 ! regulation of phosphatase activity +relationship: part_of GO:0010866 ! regulation of triglyceride biosynthetic process +relationship: part_of GO:0071071 ! regulation of phospholipid biosynthetic process + +[Term] +id: GO:1903740 +name: positive regulation of phosphatidate phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:25359770] +synonym: "activation of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidate phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity +relationship: part_of GO:0010867 ! positive regulation of triglyceride biosynthetic process +relationship: part_of GO:0071073 ! positive regulation of phospholipid biosynthetic process + +[Term] +id: GO:1903741 +name: negative regulation of phosphatidate phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity." [GO_REF:0000059, GOC:rn, GOC:TermGenie, PMID:22334681] +synonym: "down regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidate phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 3-sn-phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of acid phosphatidyl phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatic acid phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatic acid phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidate phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidate phosphohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid phosphatase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3-sn-phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of acid phosphatidyl phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatic acid phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatic acid phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidate phosphohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidic acid phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0010923 ! negative regulation of phosphatase activity +is_a: GO:1903730 ! regulation of phosphatidate phosphatase activity +relationship: part_of GO:0010868 ! negative regulation of triglyceride biosynthetic process +relationship: part_of GO:0071072 ! negative regulation of phospholipid biosynthetic process + +[Term] +id: GO:1903742 +name: regulation of anterograde synaptic vesicle transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] +subset: goslim_synapse +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +is_a: GO:1902803 ! regulation of synaptic vesicle transport +relationship: regulates GO:0048490 ! anterograde synaptic vesicle transport + +[Term] +id: GO:1903743 +name: negative regulation of anterograde synaptic vesicle transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] +synonym: "down regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie] +is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule +is_a: GO:1902804 ! negative regulation of synaptic vesicle transport +is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport +relationship: negatively_regulates GO:0048490 ! anterograde synaptic vesicle transport + +[Term] +id: GO:1903744 +name: positive regulation of anterograde synaptic vesicle transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anterograde synaptic vesicle transport." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] +synonym: "activation of anterograde synaptic vesicle transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anterograde synaptic vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule +is_a: GO:1902805 ! positive regulation of synaptic vesicle transport +is_a: GO:1903742 ! regulation of anterograde synaptic vesicle transport +relationship: positively_regulates GO:0048490 ! anterograde synaptic vesicle transport + +[Term] +id: GO:1903745 +name: negative regulation of pharyngeal pumping +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] +synonym: "down regulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "down regulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "down-regulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "down-regulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "downregulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "downregulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "inhibition of pharyngeal pumping" NARROW [GOC:TermGenie] +synonym: "inhibition of pumping behavior" RELATED [GOC:TermGenie] +synonym: "negative regulation of pumping behavior" RELATED [GOC:TermGenie] +is_a: GO:0043051 ! regulation of pharyngeal pumping +is_a: GO:1903999 ! negative regulation of eating behavior +relationship: negatively_regulates GO:0043050 ! pharyngeal pumping + +[Term] +id: GO:1903746 +name: positive regulation of pharyngeal pumping +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pharyngeal pumping." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, pmid:25329901] +synonym: "activation of pharyngeal pumping" NARROW [GOC:TermGenie] +synonym: "activation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "positive regulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "up regulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "up regulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "up-regulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "up-regulation of pumping behavior" RELATED [GOC:TermGenie] +synonym: "upregulation of pharyngeal pumping" EXACT [GOC:TermGenie] +synonym: "upregulation of pumping behavior" RELATED [GOC:TermGenie] +is_a: GO:0043051 ! regulation of pharyngeal pumping +is_a: GO:1904000 ! positive regulation of eating behavior +relationship: positively_regulates GO:0043050 ! pharyngeal pumping + +[Term] +id: GO:1903747 +name: regulation of establishment of protein localization to mitochondrion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] +synonym: "regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0070201 ! regulation of establishment of protein localization +relationship: regulates GO:0072655 ! establishment of protein localization to mitochondrion + +[Term] +id: GO:1903748 +name: negative regulation of establishment of protein localization to mitochondrion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] +synonym: "down regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion +is_a: GO:1904950 ! negative regulation of establishment of protein localization +relationship: negatively_regulates GO:0072655 ! establishment of protein localization to mitochondrion + +[Term] +id: GO:1903749 +name: positive regulation of establishment of protein localization to mitochondrion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to mitochondrion." [GO_REF:0000058, GOC:TermGenie, PMID:16857185] +synonym: "activation of establishment of protein localisation to mitochondrion" NARROW [GOC:TermGenie] +synonym: "activation of establishment of protein localization in mitochondrion" NARROW [GOC:TermGenie] +synonym: "activation of establishment of protein localization to mitochondrion" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localisation to mitochondrion" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localization in mitochondrion" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localization to mitochondrion" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903747 ! regulation of establishment of protein localization to mitochondrion +is_a: GO:1904951 ! positive regulation of establishment of protein localization +relationship: positively_regulates GO:0072655 ! establishment of protein localization to mitochondrion + +[Term] +id: GO:1903750 +name: regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] +synonym: "regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of hydrogen peroxide-induced apoptosis" BROAD [GOC:TermGenie] +synonym: "regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +is_a: GO:1901298 ! regulation of hydrogen peroxide-mediated programmed cell death +is_a: GO:1902175 ! regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +relationship: regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide + +[Term] +id: GO:1903751 +name: negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] +synonym: "down regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "down-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "downregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "inhibition of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "negative regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +is_a: GO:1901299 ! negative regulation of hydrogen peroxide-mediated programmed cell death +is_a: GO:1902176 ! negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +relationship: negatively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide + +[Term] +id: GO:1903752 +name: positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] +synonym: "activation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to H2O2" NARROW [GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "positive regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "up regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "up-regulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "upregulation of H2O2-induced intrinsic apoptotic signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to H2O2" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide" EXACT [GOC:TermGenie] +is_a: GO:1901300 ! positive regulation of hydrogen peroxide-mediated programmed cell death +is_a: GO:1902177 ! positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:1903750 ! regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide +relationship: positively_regulates GO:0036481 ! intrinsic apoptotic signaling pathway in response to hydrogen peroxide + +[Term] +id: GO:1903753 +name: negative regulation of p38MAPK cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade." [GO_REF:0000058, GOC:TermGenie, PMID:18681888] +synonym: "down regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of p38MAPK cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of p38MAPK cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of p38MAPK cascade" EXACT [GOC:TermGenie] +synonym: "inhibition of p38 cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of p38 MAPK cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of p38MAPK cascade" NARROW [GOC:TermGenie] +synonym: "negative regulation of p38 cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of p38 MAPK cascade" EXACT [GOC:TermGenie] +is_a: GO:0032873 ! negative regulation of stress-activated MAPK cascade +is_a: GO:1900744 ! regulation of p38MAPK cascade +relationship: negatively_regulates GO:0038066 ! p38MAPK cascade + +[Term] +id: GO:1903754 +name: cortical microtubule plus-end +namespace: cellular_component +def: "The plus-end of a cortical microtubule." [GO_REF:0000064, GOC:TermGenie, GOC:vw] +synonym: "cortical microtubule plus end" EXACT [] +is_a: GO:1904511 ! cytoplasmic microtubule plus-end +relationship: part_of GO:0055028 ! cortical microtubule + +[Term] +id: GO:1903755 +name: positive regulation of SUMO transferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of SUMO transferase activity." [GO_REF:0000059, GOC:PARL, GOC:rl, GOC:TermGenie, PMID:19955185] +synonym: "activation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] +synonym: "activation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] +synonym: "activation of SUMO transferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] +synonym: "positive regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] +synonym: "up regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] +synonym: "up regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] +synonym: "up regulation of SUMO transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] +synonym: "up-regulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of SUMO transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of SMT3 conjugating enzyme" RELATED [GOC:TermGenie] +synonym: "upregulation of SUMO conjugating enzyme activity" RELATED [GOC:TermGenie] +synonym: "upregulation of SUMO transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1903182 ! regulation of SUMO transferase activity + +[Term] +id: GO:1903759 +name: obsolete signal transduction involved in regulation of aerobic respiration +namespace: biological_process +def: "OBSOLETE. Any signal transduction that is involved in regulation of aerobic respiration." [GO_REF:0000060, GOC:TermGenie, PMID:19266076] +comment: The reason for obsoletion is that this represents a GO-CAM model. +synonym: "signaling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] +synonym: "signaling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] +synonym: "signalling cascade involved in regulation of aerobic respiration" NARROW [GOC:TermGenie] +synonym: "signalling pathway involved in regulation of aerobic respiration" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903760 +name: regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] +synonym: "regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1903761 +name: negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] +synonym: "down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity +is_a: GO:1905025 ! negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential + +[Term] +id: GO:1903762 +name: positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:18337493] +synonym: "activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1903760 ! regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization +is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity +is_a: GO:1905026 ! positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential + +[Term] +id: GO:1903763 +name: gap junction channel activity involved in cell communication by electrical coupling +namespace: molecular_function +def: "Any gap junction channel activity that is involved in cell communication by electrical coupling." [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307] +synonym: "connexin involved in cell communication by electrical coupling" RELATED [GOC:TermGenie] +synonym: "innexin channel activity involved in cell communication by electrical coupling" EXACT [GOC:TermGenie] +synonym: "innexin involved in cell communication by electrical coupling" NARROW [GOC:TermGenie] +is_a: GO:0005243 ! gap junction channel activity + +[Term] +id: GO:1903764 +name: regulation of potassium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1902302 +def: "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] +synonym: "regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "regulation of potassium export across plasma membrane" BROAD [GOC:TermGenie] +synonym: "regulation of potassium ion export" BROAD [] +is_a: GO:1901379 ! regulation of potassium ion transmembrane transport +relationship: regulates GO:0097623 ! potassium ion export across plasma membrane + +[Term] +id: GO:1903765 +name: negative regulation of potassium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1902303 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] +synonym: "down regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "down regulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "down regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "down-regulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "down-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of potassium export" BROAD [GOC:TermGenie] +synonym: "downregulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "downregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of potassium export" NARROW [GOC:TermGenie] +synonym: "inhibition of potassium ion export" RELATED [GOC:TermGenie] +synonym: "inhibition of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "negative regulation of potassium ion export" BROAD [] +is_a: GO:1901380 ! negative regulation of potassium ion transmembrane transport +is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane +relationship: negatively_regulates GO:0097623 ! potassium ion export across plasma membrane + +[Term] +id: GO:1903766 +name: positive regulation of potassium ion export across plasma membrane +namespace: biological_process +alt_id: GO:1902304 +def: "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991] +synonym: "activation of potassium export" RELATED [GOC:TermGenie] +synonym: "activation of potassium ion export" RELATED [GOC:TermGenie] +synonym: "activation of potassium ion export across plasma membrane" RELATED [GOC:TermGenie] +synonym: "positive regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "positive regulation of potassium ion export" BROAD [] +synonym: "up regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "up regulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "up regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of potassium export" BROAD [GOC:TermGenie] +synonym: "up-regulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "up-regulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of potassium export" BROAD [GOC:TermGenie] +synonym: "upregulation of potassium ion export" BROAD [GOC:TermGenie] +synonym: "upregulation of potassium ion export across plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1901381 ! positive regulation of potassium ion transmembrane transport +is_a: GO:1903764 ! regulation of potassium ion export across plasma membrane +relationship: positively_regulates GO:0097623 ! potassium ion export across plasma membrane + +[Term] +id: GO:1903767 +name: sweet taste receptor complex +namespace: cellular_component +def: "A protein complex which is capable of sweet taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576] +is_a: GO:1903768 ! taste receptor complex + +[Term] +id: GO:1903768 +name: taste receptor complex +namespace: cellular_component +def: "A protein complex which is capable of taste receptor activity." [GO_REF:0000088, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16720576] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1903769 +name: negative regulation of cell proliferation in bone marrow +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in bone marrow." [GO_REF:0000058, GOC:TermGenie, PMID:9241534] +synonym: "down regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] +synonym: "down-regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] +synonym: "downregulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation in bone marrow" EXACT [GOC:TermGenie] +synonym: "inhibition of bone marrow cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of cell proliferation in bone marrow" NARROW [GOC:TermGenie] +synonym: "negative regulation of bone marrow cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0071863 ! regulation of cell proliferation in bone marrow +relationship: negatively_regulates GO:0071838 ! cell proliferation in bone marrow + +[Term] +id: GO:1903770 +name: negative regulation of beta-galactosidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518] +synonym: "down regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "down regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "down regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "down regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "down regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "down regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "down regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "down regulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "down-regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "down-regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "down-regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "down-regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "down-regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "down-regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "down-regulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "downregulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "downregulation of lactozym" RELATED [GOC:TermGenie] +synonym: "downregulation of maxilact" RELATED [GOC:TermGenie] +synonym: "downregulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "downregulation of S 2107" RELATED [GOC:TermGenie] +synonym: "downregulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "downregulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of beta-D-galactanase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-D-lactosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-galactosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-lactosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrolact" RELATED [GOC:TermGenie] +synonym: "inhibition of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "inhibition of lactozym" RELATED [GOC:TermGenie] +synonym: "inhibition of maxilact" RELATED [GOC:TermGenie] +synonym: "inhibition of oryzatym" RELATED [GOC:TermGenie] +synonym: "inhibition of S 2107" RELATED [GOC:TermGenie] +synonym: "inhibition of sumiklat" RELATED [GOC:TermGenie] +synonym: "inhibition of trilactase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "negative regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "negative regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "negative regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "negative regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "negative regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "negative regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "negative regulation of trilactase activity" EXACT [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity + +[Term] +id: GO:1903771 +name: positive regulation of beta-galactosidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:11927518] +synonym: "activation of beta-D-galactanase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-D-galactoside galactohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-D-lactosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-galactosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-lactosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of exo-(1->4)-beta-D-galactanase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrolact" RELATED [GOC:TermGenie] +synonym: "activation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "activation of lactozym" RELATED [GOC:TermGenie] +synonym: "activation of maxilact" RELATED [GOC:TermGenie] +synonym: "activation of oryzatym" RELATED [GOC:TermGenie] +synonym: "activation of S 2107" RELATED [GOC:TermGenie] +synonym: "activation of sumiklat" RELATED [GOC:TermGenie] +synonym: "activation of trilactase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "positive regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "positive regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "positive regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "positive regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "positive regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "positive regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "positive regulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "up regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "up regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "up regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "up regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "up regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "up regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "up regulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "up-regulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "up-regulation of lactozym" RELATED [GOC:TermGenie] +synonym: "up-regulation of maxilact" RELATED [GOC:TermGenie] +synonym: "up-regulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "up-regulation of S 2107" RELATED [GOC:TermGenie] +synonym: "up-regulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "up-regulation of trilactase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-D-galactoside galactohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-D-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-galactosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-lactosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of exo-(1->4)-beta-D-galactanase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrolact" RELATED [GOC:TermGenie] +synonym: "upregulation of lactose hydrolysis" RELATED [GOC:TermGenie] +synonym: "upregulation of lactozym" RELATED [GOC:TermGenie] +synonym: "upregulation of maxilact" RELATED [GOC:TermGenie] +synonym: "upregulation of oryzatym" RELATED [GOC:TermGenie] +synonym: "upregulation of S 2107" RELATED [GOC:TermGenie] +synonym: "upregulation of sumiklat" RELATED [GOC:TermGenie] +synonym: "upregulation of trilactase activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity + +[Term] +id: GO:1903772 +name: regulation of viral budding via host ESCRT complex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] +synonym: "regulation of host-assisted viral budding" BROAD [GOC:TermGenie] +synonym: "regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0039702 ! viral budding via host ESCRT complex + +[Term] +id: GO:1903773 +name: negative regulation of viral budding via host ESCRT complex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] +synonym: "down regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "down regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "down-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +synonym: "downregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "downregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +synonym: "inhibition of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "inhibition of viral budding via host ESCRT complex" NARROW [GOC:TermGenie] +synonym: "negative regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex +is_a: GO:1903901 ! negative regulation of viral life cycle +relationship: negatively_regulates GO:0039702 ! viral budding via host ESCRT complex + +[Term] +id: GO:1903774 +name: positive regulation of viral budding via host ESCRT complex +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24878737] +synonym: "activation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "activation of viral budding via host ESCRT complex" NARROW [GOC:TermGenie] +synonym: "positive regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "up regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "up regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "up-regulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +synonym: "upregulation of viral budding through the ESCRT machinery" RELATED [GOC:TermGenie] +synonym: "upregulation of viral budding via host ESCRT complex" EXACT [GOC:TermGenie] +is_a: GO:1903772 ! regulation of viral budding via host ESCRT complex +is_a: GO:1903902 ! positive regulation of viral life cycle +relationship: positively_regulates GO:0039702 ! viral budding via host ESCRT complex + +[Term] +id: GO:1903775 +name: regulation of DNA double-strand break processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA double-strand break processing." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] +is_a: GO:0051052 ! regulation of DNA metabolic process +relationship: regulates GO:0000729 ! DNA double-strand break processing + +[Term] +id: GO:1903776 +name: regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends." [GO_REF:0000058, GOC:TermGenie, PMID:25203555] +is_a: GO:2000779 ! regulation of double-strand break repair +relationship: regulates GO:0000736 ! double-strand break repair via single-strand annealing, removal of nonhomologous ends + +[Term] +id: GO:1903777 +name: melibiose binding +namespace: molecular_function +def: "Binding to melibiose." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:11471732] +is_a: GO:0048030 ! disaccharide binding + +[Term] +id: GO:1903778 +name: protein localization to vacuolar membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] +synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:0072665 ! protein localization to vacuole + +[Term] +id: GO:1903779 +name: regulation of cardiac conduction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] +is_a: GO:0008016 ! regulation of heart contraction +is_a: GO:0023051 ! regulation of signaling +relationship: regulates GO:0061337 ! cardiac conduction + +[Term] +id: GO:1903780 +name: negative regulation of cardiac conduction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] +synonym: "down regulation of cardiac conduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac conduction" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac conduction" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac conduction" NARROW [GOC:TermGenie] +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903779 ! regulation of cardiac conduction +relationship: negatively_regulates GO:0061337 ! cardiac conduction + +[Term] +id: GO:1903781 +name: positive regulation of cardiac conduction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac conduction." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:12967627] +synonym: "activation of cardiac conduction" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac conduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac conduction" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac conduction" EXACT [GOC:TermGenie] +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903779 ! regulation of cardiac conduction +relationship: positively_regulates GO:0061337 ! cardiac conduction + +[Term] +id: GO:1903782 +name: regulation of sodium ion import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport +relationship: regulates GO:0098719 ! sodium ion import across plasma membrane + +[Term] +id: GO:1903783 +name: negative regulation of sodium ion import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] +synonym: "down regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] +is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport +is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane +relationship: negatively_regulates GO:0098719 ! sodium ion import across plasma membrane + +[Term] +id: GO:1903784 +name: positive regulation of sodium ion import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium ion import across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:19376779] +synonym: "activation of sodium ion import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "up regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of sodium ion import across plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport +is_a: GO:1903782 ! regulation of sodium ion import across plasma membrane +relationship: positively_regulates GO:0098719 ! sodium ion import across plasma membrane + +[Term] +id: GO:1903785 +name: L-valine transmembrane transport +namespace: biological_process +def: "The directed movement of L-valine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20944394] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015829 ! valine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903786 +name: regulation of glutathione biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "regulation of glutathione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: regulates GO:0006750 ! glutathione biosynthetic process + +[Term] +id: GO:1903787 +name: negative regulation of glutathione biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "down regulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "downregulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of glutathione anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of glutathione biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of glutathione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of glutathione formation" NARROW [GOC:TermGenie] +synonym: "inhibition of glutathione synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutathione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1903786 ! regulation of glutathione biosynthetic process +relationship: negatively_regulates GO:0006750 ! glutathione biosynthetic process + +[Term] +id: GO:1903788 +name: positive regulation of glutathione biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutathione biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of glutathione anabolism" NARROW [GOC:TermGenie] +synonym: "activation of glutathione biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of glutathione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of glutathione formation" NARROW [GOC:TermGenie] +synonym: "activation of glutathione synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "up regulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutathione synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione formation" EXACT [GOC:TermGenie] +synonym: "upregulation of glutathione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1903786 ! regulation of glutathione biosynthetic process +relationship: positively_regulates GO:0006750 ! glutathione biosynthetic process + +[Term] +id: GO:1903789 +name: regulation of amino acid transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amino acid transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:16115814] +synonym: "regulation of amino acid membrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0003333 ! amino acid transmembrane transport + +[Term] +id: GO:1903790 +name: guanine nucleotide transmembrane transport +namespace: biological_process +def: "The process in which a guanyl nucleotide is transported across a membrane." [GO_REF:0000069, GOC:dph, GOC:TermGenie, GOC:vw, PMID:25320081] +synonym: "guanyl nucleotide transmembrane transport" EXACT [] +is_a: GO:0001408 ! guanine nucleotide transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport + +[Term] +id: GO:1903791 +name: uracil transmembrane transport +namespace: biological_process +def: "The process in which uracil is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:8948441] +is_a: GO:0015857 ! uracil transport +is_a: GO:1904082 ! pyrimidine nucleobase transmembrane transport + +[Term] +id: GO:1903792 +name: negative regulation of anion transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "down regulation of anion transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anion transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anion transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anion transport" NARROW [GOC:TermGenie] +is_a: GO:0043271 ! negative regulation of ion transport +is_a: GO:0044070 ! regulation of anion transport +relationship: negatively_regulates GO:0006820 ! anion transport + +[Term] +id: GO:1903793 +name: positive regulation of anion transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anion transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "activation of anion transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anion transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anion transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anion transport" EXACT [GOC:TermGenie] +is_a: GO:0043270 ! positive regulation of ion transport +is_a: GO:0044070 ! regulation of anion transport +relationship: positively_regulates GO:0006820 ! anion transport + +[Term] +id: GO:1903794 +name: cortisol binding +namespace: molecular_function +def: "Binding to cortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:18483153] +is_a: GO:0043178 ! alcohol binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1903795 +name: regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: regulates GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1903796 +name: negative regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "down regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "downregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "inhibition of inorganic anion membrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "inhibition of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "negative regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +relationship: negatively_regulates GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1903797 +name: positive regulation of inorganic anion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:11336802] +synonym: "activation of inorganic anion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of inorganic anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "activation of transmembrane inorganic anion transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "up regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +synonym: "upregulation of inorganic anion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of inorganic anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of transmembrane inorganic anion transport" EXACT [GOC:TermGenie] +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +relationship: positively_regulates GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1903798 +name: regulation of production of miRNAs involved in gene silencing by miRNA +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "regulation of microRNA processing" BROAD [GOC:TermGenie] +synonym: "regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +is_a: GO:0070920 ! regulation of production of small RNA involved in gene silencing by RNA +relationship: regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:1903799 +name: negative regulation of production of miRNAs involved in gene silencing by miRNA +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "down regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "down regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "down regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "down regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "down regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "down regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "down-regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "down-regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "down-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "down-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "downregulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "downregulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "downregulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "downregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "downregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "inhibition of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie] +synonym: "inhibition of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "inhibition of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie] +synonym: "inhibition of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of miRNA processing" NARROW [GOC:TermGenie] +synonym: "inhibition of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie] +synonym: "inhibition of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie] +synonym: "inhibition of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "negative regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "negative regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "negative regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "negative regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "negative regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:0060965 ! negative regulation of gene silencing by miRNA +is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA +relationship: negatively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:1903800 +name: positive regulation of production of miRNAs involved in gene silencing by miRNA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "activation of gene silencing by miRNA, production of miRNAs" NARROW [GOC:TermGenie] +synonym: "activation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "activation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "activation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "activation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "activation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "activation of microRNA-mediated gene silencing, production of microRNAs" NARROW [GOC:TermGenie] +synonym: "activation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "activation of miRNA processing" NARROW [GOC:TermGenie] +synonym: "activation of miRNA-mediated gene silencing, production of miRNAs" NARROW [GOC:TermGenie] +synonym: "activation of production of microRNAs involved in gene silencing by microRNA" NARROW [GOC:TermGenie] +synonym: "activation of production of miRNAs involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "positive regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "positive regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "positive regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "positive regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "positive regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "up regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "up regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "up regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "up regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "up-regulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "up-regulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "up-regulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "up-regulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of gene silencing by miRNA, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "upregulation of microRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of microRNA biosynthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of microRNA biosynthetic process" RELATED [GOC:TermGenie] +synonym: "upregulation of microRNA metabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of microRNA metabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of microRNA-mediated gene silencing, production of microRNAs" EXACT [GOC:TermGenie] +synonym: "upregulation of miRNA biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of miRNA processing" EXACT [GOC:TermGenie] +synonym: "upregulation of miRNA-mediated gene silencing, production of miRNAs" EXACT [GOC:TermGenie] +synonym: "upregulation of production of microRNAs involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of production of miRNAs involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:1903798 ! regulation of production of miRNAs involved in gene silencing by miRNA +is_a: GO:2000637 ! positive regulation of gene silencing by miRNA +relationship: positively_regulates GO:0035196 ! production of miRNAs involved in gene silencing by miRNA + +[Term] +id: GO:1903801 +name: L-leucine import across plasma membrane +namespace: biological_process +alt_id: GO:0060356 +def: "The directed movement of L-leucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-leucine import" BROAD [] +synonym: "L-leucine import into cell" EXACT [] +synonym: "L-leucine uptake" NARROW [] +synonym: "leucine import" BROAD [] +synonym: "leucine uptake" EXACT [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098713 ! leucine import across plasma membrane +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903803 +name: L-glutamine import across plasma membrane +namespace: biological_process +alt_id: GO:0036229 +def: "The directed movement of L-glutamine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-glutamine import" BROAD [] +synonym: "L-glutamine import into cell" EXACT [] +synonym: "L-glutamine uptake" EXACT [GOC:bf] +is_a: GO:0006868 ! glutamine transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903804 +name: glycine import across plasma membrane +namespace: biological_process +alt_id: GO:0036233 +def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "glycine import" BROAD [] +synonym: "glycine import into cell" EXACT [] +is_a: GO:0015816 ! glycine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903805 +name: L-valine import across plasma membrane +namespace: biological_process +alt_id: GO:0090468 +def: "The directed movement of L-valine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-valine import into cell" EXACT [] +synonym: "valine import" NARROW [] +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:1903785 ! L-valine transmembrane transport + +[Term] +id: GO:1903806 +name: L-isoleucine import across plasma membrane +namespace: biological_process +alt_id: GO:0090476 +alt_id: GO:0090477 +def: "The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "isoleucine import" BROAD [] +synonym: "L-isoleucine import" BROAD [] +synonym: "L-isoleucine import into cell" EXACT [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport +is_a: GO:1903714 ! isoleucine transmembrane transport + +[Term] +id: GO:1903807 +name: L-threonine import across plasma membrane +namespace: biological_process +alt_id: GO:0036231 +def: "The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-threonine import" BROAD [] +synonym: "L-threonine import into cell" EXACT [] +synonym: "L-threonine uptake" EXACT [GOC:bf] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015826 ! threonine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903808 +name: L-tyrosine import across plasma membrane +namespace: biological_process +alt_id: GO:0036232 +def: "The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-tyrosine import" BROAD [] +synonym: "L-tyrosine import into cell" EXACT [] +synonym: "L-tyrosine uptake" EXACT [GOC:bf] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015828 ! tyrosine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903810 +name: L-histidine import across plasma membrane +namespace: biological_process +alt_id: GO:0061460 +alt_id: GO:0090466 +def: "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "histidine import" BROAD [] +synonym: "L-histidine import" BROAD [] +synonym: "L-histidine import into cell" EXACT [] +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:1903811 +name: L-asparagine import across plasma membrane +namespace: biological_process +alt_id: GO:0090469 +def: "The directed movement of L-asparagine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "asparagine import" BROAD [] +synonym: "L-asparagine import into cell" EXACT [] +is_a: GO:0006867 ! asparagine transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport +is_a: GO:1903713 ! asparagine transmembrane transport + +[Term] +id: GO:1903812 +name: L-serine import across plasma membrane +namespace: biological_process +def: "The directed movement of L-serine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "L-serine import into cell" EXACT [] +is_a: GO:0015825 ! L-serine transport +is_a: GO:0098718 ! serine import across plasma membrane +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1903814 +name: regulation of collecting lymphatic vessel constriction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] +synonym: "regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +is_a: GO:0044057 ! regulation of system process +is_a: GO:0090066 ! regulation of anatomical structure size +relationship: regulates GO:1990192 ! collecting lymphatic vessel constriction + +[Term] +id: GO:1903815 +name: negative regulation of collecting lymphatic vessel constriction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] +synonym: "down regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "down regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "down-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "down-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "downregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "downregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "inhibition of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie] +synonym: "inhibition of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie] +synonym: "negative regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction +relationship: negatively_regulates GO:1990192 ! collecting lymphatic vessel constriction + +[Term] +id: GO:1903816 +name: positive regulation of collecting lymphatic vessel constriction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collecting lymphatic vessel constriction." [GO_REF:0000058, GOC:TermGenie, PMID:23897233] +synonym: "activation of collecting lymphatic vessel constriction" NARROW [GOC:TermGenie] +synonym: "activation of lymphatic vessel myogenic constriction" NARROW [GOC:TermGenie] +synonym: "positive regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "up regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "up regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "up-regulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "up-regulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +synonym: "upregulation of collecting lymphatic vessel constriction" EXACT [GOC:TermGenie] +synonym: "upregulation of lymphatic vessel myogenic constriction" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1903814 ! regulation of collecting lymphatic vessel constriction +relationship: positively_regulates GO:1990192 ! collecting lymphatic vessel constriction + +[Term] +id: GO:1903817 +name: negative regulation of voltage-gated potassium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] +synonym: "down regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage gated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1903818 +name: positive regulation of voltage-gated potassium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:19219384] +synonym: "activation of voltage gated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-dependent potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated potassium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated potassium ion channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-sensitive potassium channel" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-dependent potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-sensitive potassium channel" EXACT [GOC:TermGenie] +is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1903819 +name: obsolete detection of stimulus involved in mitotic cytokinesis checkpoint +namespace: biological_process +def: "OBSOLETE. Any detection of stimulus that is involved in a mitotic cytokinesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "perception of stimulus involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus detection involved in mitotic cytokinesis checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in mitotic cytokinesis checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903821 +name: obsolete detection of stimulus involved in morphogenesis checkpoint +namespace: biological_process +def: "OBSOLETE. Any detection of stimulus that is involved in morphogenesis checkpoint." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] +comment: This term was obsoleted because it corresponds to a molecular function. +synonym: "detection of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie] +synonym: "perception of stimulus involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "perception of stimulus involved in septin checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus detection involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus detection involved in septin checkpoint" RELATED [GOC:TermGenie] +synonym: "stimulus sensing involved in morphogenesis checkpoint" EXACT [GOC:TermGenie] +synonym: "stimulus sensing involved in septin checkpoint" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1903823 +name: telomere single strand break repair +namespace: biological_process +def: "Single strand break repair that takes place in a telomere." [GO_REF:0000062, GOC:TermGenie, PMID:24374808] +synonym: "single strand break repair in telomere" EXACT [GOC:TermGenie] +synonym: "telomere single-strand break repair" EXACT [] +synonym: "telomere SSBR" RELATED [] +synonym: "telomeric single strand break repair" EXACT [] +is_a: GO:0000012 ! single strand break repair + +[Term] +id: GO:1903824 +name: negative regulation of telomere single strand break repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere single strand break repair." [GO_REF:0000058, GOC:TermGenie, PMID:24374808] +synonym: "down regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] +synonym: "down regulation of telomere single strand break repair" EXACT [GOC:TermGenie] +synonym: "down regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] +synonym: "down regulation of telomere SSBR" RELATED [GOC:TermGenie] +synonym: "down regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere single strand break repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere SSBR" RELATED [GOC:TermGenie] +synonym: "down-regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] +synonym: "downregulation of single strand break repair in telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere single strand break repair" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere single-strand break repair" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere SSBR" RELATED [GOC:TermGenie] +synonym: "downregulation of telomeric single strand break repair" EXACT [GOC:TermGenie] +synonym: "inhibition of single strand break repair in telomere" NARROW [GOC:TermGenie] +synonym: "inhibition of telomere single strand break repair" NARROW [GOC:TermGenie] +synonym: "inhibition of telomere single-strand break repair" NARROW [GOC:TermGenie] +synonym: "inhibition of telomere SSBR" RELATED [GOC:TermGenie] +synonym: "inhibition of telomeric single strand break repair" NARROW [GOC:TermGenie] +synonym: "negative regulation of single strand break repair in telomere" EXACT [GOC:TermGenie] +synonym: "negative regulation of telomere single-strand break repair" EXACT [GOC:TermGenie] +synonym: "negative regulation of telomere SSBR" RELATED [GOC:TermGenie] +synonym: "negative regulation of telomeric single strand break repair" EXACT [GOC:TermGenie] +is_a: GO:1903517 ! negative regulation of single strand break repair +relationship: negatively_regulates GO:1903823 ! telomere single strand break repair + +[Term] +id: GO:1903825 +name: organic acid transmembrane transport +namespace: biological_process +def: "The process in which an organic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] +is_a: GO:0015849 ! organic acid transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1903826 +name: L-arginine transmembrane transport +namespace: biological_process +alt_id: GO:0015809 +alt_id: GO:0043091 +alt_id: GO:1902023 +alt_id: GO:1903400 +def: "The directed movement of L-arginine across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:18357653, PMID:22822152, PMID:8195186] +synonym: "arginine transmembrane transport" RELATED [] +synonym: "arginine transport" BROAD [] +synonym: "L-arginine import" NARROW [] +synonym: "L-arginine transport" BROAD [] +synonym: "L-arginine uptake" NARROW [] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport +is_a: GO:1990822 ! basic amino acid transmembrane transport + +[Term] +id: GO:1903828 +name: negative regulation of protein localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein localization" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein localization" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular protein localisation" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein localization" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein localization" EXACT [] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0008104 ! protein localization + +[Term] +id: GO:1903829 +name: positive regulation of protein localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a protein localization." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "positive regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein localization" EXACT [] +synonym: "up regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein localization" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein localisation" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein localization" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0008104 ! protein localization + +[Term] +id: GO:1903830 +name: magnesium ion transmembrane transport +namespace: biological_process +def: "The directed movement of magnesium ion across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11254124] +is_a: GO:0015693 ! magnesium ion transport +is_a: GO:0098662 ! inorganic cation transmembrane transport + +[Term] +id: GO:1903831 +name: signal transduction involved in cellular response to ammonium ion +namespace: biological_process +def: "Any signal transduction that is involved in cellular response to ammonium ion." [GO_REF:0000060, GOC:TermGenie, PMID:16297994] +synonym: "signaling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] +synonym: "signaling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] +synonym: "signalling cascade involved in cellular response to ammonium ion" NARROW [GOC:TermGenie] +synonym: "signalling pathway involved in cellular response to ammonium ion" RELATED [GOC:TermGenie] +is_a: GO:0007165 ! signal transduction +relationship: part_of GO:0071242 ! cellular response to ammonium ion + +[Term] +id: GO:1903832 +name: regulation of cellular response to amino acid starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0034198 ! cellular response to amino acid starvation + +[Term] +id: GO:1903833 +name: positive regulation of cellular response to amino acid starvation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation." [GO_REF:0000058, GOC:TermGenie, PMID:25002487, PMID:7623840] +synonym: "activation of cellular response to amino acid starvation" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to amino acid starvation" EXACT [GOC:TermGenie] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0032109 ! positive regulation of response to nutrient levels +is_a: GO:1903832 ! regulation of cellular response to amino acid starvation +relationship: positively_regulates GO:0034198 ! cellular response to amino acid starvation + +[Term] +id: GO:1903837 +name: regulation of mRNA 3'-UTR binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] +synonym: "regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +is_a: GO:1902415 ! regulation of mRNA binding + +[Term] +id: GO:1903838 +name: negative regulation of mRNA 3'-UTR binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] +synonym: "down regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +synonym: "inhibition of mRNA 3' UTR binding" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA 3'-UTR binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding +is_a: GO:1904572 ! negative regulation of mRNA binding + +[Term] +id: GO:1903839 +name: positive regulation of mRNA 3'-UTR binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-UTR binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:19575011] +synonym: "activation of mRNA 3' UTR binding" NARROW [GOC:TermGenie] +synonym: "activation of mRNA 3'-UTR binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA 3' UTR binding" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA 3'-UTR binding" EXACT [GOC:TermGenie] +is_a: GO:1902416 ! positive regulation of mRNA binding +is_a: GO:1903837 ! regulation of mRNA 3'-UTR binding + +[Term] +id: GO:1903840 +name: response to arsenite(3-) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] +is_a: GO:1903842 ! response to arsenite ion + +[Term] +id: GO:1903841 +name: cellular response to arsenite(3-) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite(3-) stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] +is_a: GO:1903840 ! response to arsenite(3-) +is_a: GO:1903843 ! cellular response to arsenite ion + +[Term] +id: GO:1903842 +name: response to arsenite ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:0046685 ! response to arsenic-containing substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903843 +name: cellular response to arsenite ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenite ion stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:12106899] +is_a: GO:0071243 ! cellular response to arsenic-containing substance +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1903842 ! response to arsenite ion + +[Term] +id: GO:1903844 +name: regulation of cellular response to transforming growth factor beta stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus + +[Term] +id: GO:1903845 +name: negative regulation of cellular response to transforming growth factor beta stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "down regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus +relationship: negatively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus + +[Term] +id: GO:1903846 +name: positive regulation of cellular response to transforming growth factor beta stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to transforming growth factor beta stimulus." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "activation of cellular response to TGF-beta stimulus" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to TGFbeta stimulus" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to transforming growth factor beta stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to TGF-beta stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to TGFbeta stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to transforming growth factor beta stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus +relationship: positively_regulates GO:0071560 ! cellular response to transforming growth factor beta stimulus + +[Term] +id: GO:1903847 +name: regulation of aorta morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +is_a: GO:1905651 ! regulation of artery morphogenesis +relationship: regulates GO:0035909 ! aorta morphogenesis + +[Term] +id: GO:1903848 +name: negative regulation of aorta morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "down regulation of aorta morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of aorta morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of aorta morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:1903847 ! regulation of aorta morphogenesis +is_a: GO:1905652 ! negative regulation of artery morphogenesis +relationship: negatively_regulates GO:0035909 ! aorta morphogenesis + +[Term] +id: GO:1903849 +name: positive regulation of aorta morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aorta morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22269326] +synonym: "activation of aorta morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of aorta morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of aorta morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of aorta morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:1903847 ! regulation of aorta morphogenesis +is_a: GO:1905653 ! positive regulation of artery morphogenesis +relationship: positively_regulates GO:0035909 ! aorta morphogenesis + +[Term] +id: GO:1903850 +name: regulation of cristae formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] +comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype +is_a: GO:0010821 ! regulation of mitochondrion organization +relationship: regulates GO:0042407 ! cristae formation + +[Term] +id: GO:1903851 +name: negative regulation of cristae formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] +comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype +synonym: "down regulation of cristae formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cristae formation" EXACT [GOC:TermGenie] +synonym: "downregulation of cristae formation" EXACT [GOC:TermGenie] +synonym: "inhibition of cristae formation" NARROW [GOC:TermGenie] +is_a: GO:0010823 ! negative regulation of mitochondrion organization +is_a: GO:1903850 ! regulation of cristae formation +relationship: negatively_regulates GO:0042407 ! cristae formation + +[Term] +id: GO:1903852 +name: positive regulation of cristae formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cristae formation." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:19279012] +comment: AN example of this is PINK1 in human (Q9BXM7) in PMID:19279012 inferred from mutant phenotype +synonym: "activation of cristae formation" NARROW [GOC:TermGenie] +synonym: "up regulation of cristae formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cristae formation" EXACT [GOC:TermGenie] +synonym: "upregulation of cristae formation" EXACT [GOC:TermGenie] +is_a: GO:0010822 ! positive regulation of mitochondrion organization +is_a: GO:1903850 ! regulation of cristae formation +relationship: positively_regulates GO:0042407 ! cristae formation + +[Term] +id: GO:1903853 +name: regulation of stress response to copper ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] +synonym: "regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "regulation of stress response to copper" BROAD [GOC:TermGenie] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:1990169 ! stress response to copper ion + +[Term] +id: GO:1903854 +name: negative regulation of stress response to copper ion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] +synonym: "down regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "down regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "down regulation of stress response to copper ion" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "down-regulation of stress response to copper ion" EXACT [GOC:TermGenie] +synonym: "downregulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "downregulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "downregulation of stress response to copper ion" EXACT [GOC:TermGenie] +synonym: "inhibition of response to copper ion stress" NARROW [GOC:TermGenie] +synonym: "inhibition of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "inhibition of stress response to copper ion" NARROW [GOC:TermGenie] +synonym: "negative regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to copper toxicity" RELATED [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1903853 ! regulation of stress response to copper ion +relationship: negatively_regulates GO:1990169 ! stress response to copper ion + +[Term] +id: GO:1903855 +name: positive regulation of stress response to copper ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stress response to copper ion." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:23437011] +synonym: "activation of response to copper ion stress" NARROW [GOC:TermGenie] +synonym: "activation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "activation of stress response to copper ion" NARROW [GOC:TermGenie] +synonym: "positive regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "up regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "up regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "up regulation of stress response to copper ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "up-regulation of stress response to copper ion" EXACT [GOC:TermGenie] +synonym: "upregulation of response to copper ion stress" EXACT [GOC:TermGenie] +synonym: "upregulation of response to copper toxicity" RELATED [GOC:TermGenie] +synonym: "upregulation of stress response to copper ion" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1903853 ! regulation of stress response to copper ion +relationship: positively_regulates GO:1990169 ! stress response to copper ion + +[Term] +id: GO:1903856 +name: regulation of cytokinin dehydrogenase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363] +synonym: "regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1903857 +name: negative regulation of cytokinin dehydrogenase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity." [GO_REF:0000059, GOC:TermGenie, PMID:25535363] +synonym: "down regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinin dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytokinin dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of N6-dimethylallyladenine:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytokinin oxidase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1903856 ! regulation of cytokinin dehydrogenase activity + +[Term] +id: GO:1903858 +name: protein localization to old growing cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:17895368] +synonym: "protein localisation in old growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to old growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization in old growing cell tip" EXACT [GOC:TermGenie] +is_a: GO:1902486 ! protein localization to growing cell tip + +[Term] +id: GO:1903859 +name: regulation of dendrite extension +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] +comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0097484 ! dendrite extension + +[Term] +id: GO:1903860 +name: negative regulation of dendrite extension +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] +comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. +synonym: "down regulation of dendrite extension" EXACT [GOC:TermGenie] +synonym: "down-regulation of dendrite extension" EXACT [GOC:TermGenie] +synonym: "downregulation of dendrite extension" EXACT [GOC:TermGenie] +synonym: "inhibition of dendrite extension" NARROW [GOC:TermGenie] +synonym: "up regulation of dendrite retraction" EXACT [GOC:pad] +synonym: "up-regulation of dendrite retraction" EXACT [GOC:pad] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1903859 ! regulation of dendrite extension +relationship: negatively_regulates GO:0097484 ! dendrite extension + +[Term] +id: GO:1903861 +name: positive regulation of dendrite extension +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendrite extension." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24898855] +comment: An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. +synonym: "activation of dendrite extension" NARROW [GOC:TermGenie] +synonym: "up regulation of dendrite extension" EXACT [GOC:TermGenie] +synonym: "up-regulation of dendrite extension" EXACT [GOC:TermGenie] +synonym: "upregulation of dendrite extension" EXACT [GOC:TermGenie] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1903859 ! regulation of dendrite extension +relationship: positively_regulates GO:0097484 ! dendrite extension + +[Term] +id: GO:1903862 +name: positive regulation of oxidative phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:10225962] +synonym: "activation of oxidative phosphorylation" NARROW [GOC:TermGenie] +synonym: "activation of respiratory-chain phosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of oxidative phosphorylation" EXACT [GOC:TermGenie] +synonym: "up regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of oxidative phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of oxidative phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of respiratory-chain phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0002082 ! regulation of oxidative phosphorylation +is_a: GO:1901857 ! positive regulation of cellular respiration +is_a: GO:1903580 ! positive regulation of ATP metabolic process +relationship: positively_regulates GO:0006119 ! oxidative phosphorylation + +[Term] +id: GO:1903863 +name: P granule assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a P granule." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836] +synonym: "germline granule assembly" EXACT [GOC:TermGenie] +synonym: "germline granule formation" EXACT [GOC:TermGenie] +synonym: "P granule formation" EXACT [GOC:TermGenie] +synonym: "polar granule assembly" EXACT [GOC:TermGenie] +synonym: "polar granule formation" EXACT [GOC:TermGenie] +is_a: GO:0030719 ! P granule organization +is_a: GO:0140694 ! non-membrane-bounded organelle assembly + +[Term] +id: GO:1903864 +name: P granule disassembly +namespace: biological_process +def: "The disaggregation of a P granule into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:25535836] +synonym: "germline granule disassembly" EXACT [GOC:TermGenie] +synonym: "polar granule disassembly" EXACT [GOC:TermGenie] +is_a: GO:0030719 ! P granule organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1903865 +name: sigma factor antagonist complex +namespace: cellular_component +def: "A protein complex which is capable of sigma factor antagonist activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23687042] +is_a: GO:0005667 ! transcription regulator complex + +[Term] +id: GO:1903866 +name: palisade mesophyll development +namespace: biological_process +def: "The process whose specific outcome is the progression of a palisade mesophyll over time, from its formation to the mature structure." [GO_REF:0000080, GOC:TermGenie, PMID:24663344] +synonym: "palisade parenchyma development" RELATED [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1903867 +name: extraembryonic membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, ISBN:0073040584] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1903868 +name: regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] +synonym: "regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of MetF" RELATED [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of methylenetetrahydrofolic acid reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of MTHFR activity" BROAD [GOC:TermGenie] +synonym: "regulation of N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1903869 +name: negative regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] +synonym: "down regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of MetF" RELATED [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "down regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "down regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of MetF" RELATED [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "down-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of MetF" RELATED [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "downregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "downregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of MetF" RELATED [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie] +synonym: "inhibition of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "inhibition of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of MetF" RELATED [GOC:TermGenie] +synonym: "negative regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "negative regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity + +[Term] +id: GO:1903870 +name: positive regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." [GO_REF:0000059, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:24769206] +synonym: "activation of 5,10-CH(2)-H(4)folate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5,10-CH2-H4folate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" NARROW [GOC:TermGenie] +synonym: "activation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" NARROW [GOC:TermGenie] +synonym: "activation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" NARROW [GOC:TermGenie] +synonym: "activation of 5,10-methylenetetrahydropteroylglutamate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of MetF" RELATED [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate reductase (NAD(P)H) activity" NARROW [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate reductase (NADPH(2)) activity" NARROW [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate reductase (NADPH2)" NARROW [GOC:TermGenie] +synonym: "activation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "activation of N5,10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of N5,N10-methylenetetrahydrofolate reductase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of MetF" RELATED [GOC:TermGenie] +synonym: "positive regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "positive regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of MetF" RELATED [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "up regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "up regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of MetF" RELATED [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "up-regulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-CH(2)-H(4)folate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-CH2-H4folate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [GOC:TermGenie] +synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of MetF" RELATED [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate reductase (NAD(P)H) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate reductase (NADPH2)" EXACT [GOC:TermGenie] +synonym: "upregulation of methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [GOC:TermGenie] +synonym: "upregulation of N5,10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of N5,N10-methylenetetrahydrofolate reductase activity" EXACT [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1903868 ! regulation of methylenetetrahydrofolate reductase (NAD(P)H) activity + +[Term] +id: GO:1903871 +name: DNA recombinase mediator complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex." [GO_REF:0000079, GOC:rb, GOC:TermGenie, PMID:18347097] +synonym: "DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +is_a: GO:0090735 ! DNA repair complex assembly + +[Term] +id: GO:1903872 +name: regulation of DNA recombinase mediator complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097] +synonym: "regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1903871 ! DNA recombinase mediator complex assembly + +[Term] +id: GO:1903873 +name: negative regulation of DNA recombinase mediator complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA recombinase mediator complex assembly." [GO_REF:0000058, GOC:rb, GOC:TermGenie, PMID:18347097] +synonym: "down regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA recombinase mediator complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA recombinase mediator complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA recombinase mediator complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA recombinase mediator complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1903872 ! regulation of DNA recombinase mediator complex assembly +relationship: negatively_regulates GO:1903871 ! DNA recombinase mediator complex assembly + +[Term] +id: GO:1903875 +name: corticosterone binding +namespace: molecular_function +def: "Binding to corticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] +is_a: GO:0043178 ! alcohol binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1903876 +name: 11-deoxycortisol binding +namespace: molecular_function +def: "Binding to 11-deoxycortisol." [GO_REF:0000067, GOC:TermGenie, PMID:10802282] +is_a: GO:0043178 ! alcohol binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1903877 +name: 21-deoxycortisol binding +namespace: molecular_function +def: "Binding to 21-deoxycortisol." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] +is_a: GO:0005496 ! steroid binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:1903878 +name: 11-deoxycorticosterone binding +namespace: molecular_function +def: "Binding to 11-deoxycorticosterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] +is_a: GO:0043178 ! alcohol binding +is_a: GO:1990239 ! steroid hormone binding + +[Term] +id: GO:1903879 +name: 11beta-hydroxyprogesterone binding +namespace: molecular_function +def: "Binding to 11beta-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] +is_a: GO:0005496 ! steroid binding + +[Term] +id: GO:1903880 +name: 17alpha-hydroxyprogesterone binding +namespace: molecular_function +def: "Binding to 17alpha-hydroxyprogesterone." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10802282] +is_a: GO:0005496 ! steroid binding +is_a: GO:0043178 ! alcohol binding + +[Term] +id: GO:1903881 +name: regulation of interleukin-17-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0097400 ! interleukin-17-mediated signaling pathway + +[Term] +id: GO:1903882 +name: negative regulation of interleukin-17-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "down regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway +relationship: negatively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway + +[Term] +id: GO:1903883 +name: positive regulation of interleukin-17-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-17-mediated signaling pathway." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "activation of IL-17-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of IL-17-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-17-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of interleukin-17-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of IL-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of IL-17-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-17-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of interleukin-17-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:1903881 ! regulation of interleukin-17-mediated signaling pathway +relationship: positively_regulates GO:0097400 ! interleukin-17-mediated signaling pathway + +[Term] +id: GO:1903884 +name: regulation of chemokine (C-C motif) ligand 20 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "regulation of CCL20 production" EXACT [GOC:TermGenie] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production + +[Term] +id: GO:1903885 +name: negative regulation of chemokine (C-C motif) ligand 20 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "down regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "down regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "down regulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "down regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +synonym: "down-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "down-regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "down-regulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +synonym: "downregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "downregulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "downregulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "downregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +synonym: "inhibition of C-C motif chemokine 20 production" NARROW [GOC:TermGenie] +synonym: "inhibition of CCL-20 production" NARROW [GOC:TermGenie] +synonym: "inhibition of CCL20 production" NARROW [GOC:TermGenie] +synonym: "inhibition of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie] +synonym: "negative regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "negative regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "negative regulation of CCL20 production" EXACT [GOC:TermGenie] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production +relationship: negatively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production + +[Term] +id: GO:1903886 +name: positive regulation of chemokine (C-C motif) ligand 20 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:20054338] +synonym: "activation of C-C motif chemokine 20 production" NARROW [GOC:TermGenie] +synonym: "activation of CCL-20 production" NARROW [GOC:TermGenie] +synonym: "activation of CCL20 production" NARROW [GOC:TermGenie] +synonym: "activation of chemokine (C-C motif) ligand 20 production" NARROW [GOC:TermGenie] +synonym: "positive regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "positive regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "positive regulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "up regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "up regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "up regulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "up regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +synonym: "up-regulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "up-regulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "up-regulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "up-regulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +synonym: "upregulation of C-C motif chemokine 20 production" EXACT [GOC:TermGenie] +synonym: "upregulation of CCL-20 production" EXACT [GOC:TermGenie] +synonym: "upregulation of CCL20 production" EXACT [GOC:TermGenie] +synonym: "upregulation of chemokine (C-C motif) ligand 20 production" EXACT [GOC:TermGenie] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:1903884 ! regulation of chemokine (C-C motif) ligand 20 production +relationship: positively_regulates GO:0036392 ! chemokine (C-C motif) ligand 20 production + +[Term] +id: GO:1903888 +name: regulation of plant epidermal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0090627 ! plant epidermal cell differentiation + +[Term] +id: GO:1903889 +name: negative regulation of plant epidermal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] +synonym: "down regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of plant epidermal cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1903888 ! regulation of plant epidermal cell differentiation +relationship: negatively_regulates GO:0090627 ! plant epidermal cell differentiation + +[Term] +id: GO:1903890 +name: positive regulation of plant epidermal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plant epidermal cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:123345] +synonym: "activation of plant epidermal cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of plant epidermal cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1903888 ! regulation of plant epidermal cell differentiation +relationship: positively_regulates GO:0090627 ! plant epidermal cell differentiation + +[Term] +id: GO:1903891 +name: regulation of ATF6-mediated unfolded protein response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "regulation of ATF6 signal transduction pathway" BROAD [GOC:TermGenie] +synonym: "regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response +relationship: regulates GO:0036500 ! ATF6-mediated unfolded protein response + +[Term] +id: GO:1903892 +name: negative regulation of ATF6-mediated unfolded protein response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "down regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "down regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "down regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "down regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "down-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "downregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "downregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "downregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "downregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "downregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "inhibition of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of ATF6 branch of UPR" NARROW [GOC:TermGenie] +synonym: "inhibition of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "inhibition of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "inhibition of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "inhibition of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie] +synonym: "negative regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "negative regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response +relationship: negatively_regulates GO:0036500 ! ATF6-mediated unfolded protein response + +[Term] +id: GO:1903893 +name: positive regulation of ATF6-mediated unfolded protein response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the ATF6-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "activation of activating transcription factor 6 signaling in unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of ATF6 branch of UPR" NARROW [GOC:TermGenie] +synonym: "activation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "activation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "activation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "activation of ATF6-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum unfolded protein response; ATF6 signaling" NARROW [GOC:TermGenie] +synonym: "activation of UPR signaling by ATF6 stress sensor" NARROW [GOC:TermGenie] +synonym: "positive regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "up regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "up regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "up regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "up regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "up-regulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up-regulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +synonym: "upregulation of activating transcription factor 6 signaling in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of ATF6 branch of UPR" EXACT [GOC:TermGenie] +synonym: "upregulation of ATF6 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "upregulation of ATF6-alpha UPR branch" NARROW [GOC:TermGenie] +synonym: "upregulation of ATF6-beta UPR branch" NARROW [GOC:TermGenie] +synonym: "upregulation of ATF6-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of UPR signaling by ATF6 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903891 ! regulation of ATF6-mediated unfolded protein response +relationship: positively_regulates GO:0036500 ! ATF6-mediated unfolded protein response + +[Term] +id: GO:1903894 +name: regulation of IRE1-mediated unfolded protein response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] +synonym: "regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "regulation of IRE1 signal transduction pathway" BROAD [GOC:TermGenie] +synonym: "regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response +relationship: regulates GO:0036498 ! IRE1-mediated unfolded protein response + +[Term] +id: GO:1903895 +name: negative regulation of IRE1-mediated unfolded protein response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "down regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "down regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "down regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "down regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "down regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "down-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "down-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "down-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "down-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "downregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "downregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "downregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "downregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "downregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "inhibition of IRE1 branch of UPR" NARROW [GOC:TermGenie] +synonym: "inhibition of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "inhibition of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] +synonym: "negative regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "negative regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "negative regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "negative regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "negative regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "negative regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response +relationship: negatively_regulates GO:0036498 ! IRE1-mediated unfolded protein response + +[Term] +id: GO:1903896 +name: positive regulation of IRE1-mediated unfolded protein response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the IRE1-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "activation of endoplasmic reticulum unfolded protein response; IRE1 signaling" NARROW [GOC:TermGenie] +synonym: "activation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "activation of IRE1 branch of UPR" NARROW [GOC:TermGenie] +synonym: "activation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "activation of IRE1-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of UPR signaling by IRE1 stress sensor" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of ERN1-mediated unfolded protein response" RELATED [HGNC:3449] +synonym: "positive regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "positive regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "positive regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "positive regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "positive regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "up regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "up regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "up regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "up regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "up-regulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "up-regulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up-regulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "up-regulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "up-regulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum unfolded protein response; IRE1 signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of inositol-requiring transmembrane kinase/endonuclease signal transduction" RELATED [GOC:TermGenie] +synonym: "upregulation of IRE1 branch of UPR" EXACT [GOC:TermGenie] +synonym: "upregulation of IRE1 signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "upregulation of IRE1-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of IRE1alpha unfolded protein response" NARROW [GOC:TermGenie] +synonym: "upregulation of IRE1p unfolded protein response" NARROW [GOC:TermGenie] +synonym: "upregulation of UPR signaling by IRE1 stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903894 ! regulation of IRE1-mediated unfolded protein response +relationship: positively_regulates GO:0036498 ! IRE1-mediated unfolded protein response + +[Term] +id: GO:1903897 +name: regulation of PERK-mediated unfolded protein response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] +synonym: "regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "regulation of PERK signal transduction pathway" BROAD [GOC:TermGenie] +synonym: "regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900101 ! regulation of endoplasmic reticulum unfolded protein response +relationship: regulates GO:0036499 ! PERK-mediated unfolded protein response + +[Term] +id: GO:1903898 +name: negative regulation of PERK-mediated unfolded protein response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "down regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "down regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "down regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "down-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "down-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "downregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "downregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie] +synonym: "inhibition of PERK branch of UPR" NARROW [GOC:TermGenie] +synonym: "inhibition of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "inhibition of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie] +synonym: "negative regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] +synonym: "negative regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "negative regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900102 ! negative regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response +relationship: negatively_regulates GO:0036499 ! PERK-mediated unfolded protein response + +[Term] +id: GO:1903899 +name: positive regulation of PERK-mediated unfolded protein response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the PERK-mediated unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22013210] +synonym: "activation of endoplasmic reticulum unfolded protein response; PERK signaling" NARROW [GOC:TermGenie] +synonym: "activation of PERK branch of UPR" NARROW [GOC:TermGenie] +synonym: "activation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "activation of PERK-mediated unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of PKR-like ER kinase signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of UPR signaling by PERK stress sensor" NARROW [GOC:TermGenie] +synonym: "positive regulation of EIF2AK3-mediated unfolded protein response" RELATED [HGNC:3255] +synonym: "positive regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "positive regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "positive regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "positive regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "positive regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "up regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "up regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "up-regulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "up-regulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum unfolded protein response; PERK signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of PERK branch of UPR" EXACT [GOC:TermGenie] +synonym: "upregulation of PERK signaling in response to endoplasmic reticulum stress" RELATED [GOC:TermGenie] +synonym: "upregulation of PERK-mediated unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of PKR-like ER kinase signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of UPR signaling by PERK stress sensor" EXACT [GOC:TermGenie] +is_a: GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response +is_a: GO:1903897 ! regulation of PERK-mediated unfolded protein response +relationship: positively_regulates GO:0036499 ! PERK-mediated unfolded protein response + +[Term] +id: GO:1903900 +name: regulation of viral life cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] +synonym: "regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "regulation of viral replication" RELATED [GOC:TermGenie] +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0019058 ! viral life cycle + +[Term] +id: GO:1903901 +name: negative regulation of viral life cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] +synonym: "down regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "down regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "down regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "down regulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "down regulation of viral replication" RELATED [GOC:TermGenie] +synonym: "down-regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "down-regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "down-regulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral replication" RELATED [GOC:TermGenie] +synonym: "downregulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "downregulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "downregulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "downregulation of viral replication" RELATED [GOC:TermGenie] +synonym: "inhibition of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "inhibition of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "inhibition of viral life cycle" NARROW [GOC:TermGenie] +synonym: "inhibition of viral replication" RELATED [GOC:TermGenie] +synonym: "negative regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "negative regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "negative regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "negative regulation of viral replication" RELATED [GOC:TermGenie] +is_a: GO:0048525 ! negative regulation of viral process +is_a: GO:1903900 ! regulation of viral life cycle +relationship: negatively_regulates GO:0019058 ! viral life cycle + +[Term] +id: GO:1903902 +name: positive regulation of viral life cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral life cycle." [GO_REF:0000058, GOC:TermGenie, PMID:18005716] +synonym: "activation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "activation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "activation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "activation of viral life cycle" NARROW [GOC:TermGenie] +synonym: "activation of viral replication" RELATED [GOC:TermGenie] +synonym: "positive regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "positive regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "positive regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "positive regulation of viral replication" RELATED [GOC:TermGenie] +synonym: "up regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "up regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "up regulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of viral replication" RELATED [GOC:TermGenie] +synonym: "up-regulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "up-regulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "up-regulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral replication" RELATED [GOC:TermGenie] +synonym: "upregulation of lytic viral life cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of viral assembly, maturation, egress, and release" NARROW [GOC:TermGenie] +synonym: "upregulation of viral infectious cycle" RELATED [GOC:TermGenie] +synonym: "upregulation of viral life cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of viral replication" RELATED [GOC:TermGenie] +is_a: GO:0048524 ! positive regulation of viral process +is_a: GO:1903900 ! regulation of viral life cycle +relationship: positively_regulates GO:0019058 ! viral life cycle + +[Term] +id: GO:1903903 +name: regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "regulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:2000114 ! regulation of establishment of cell polarity +relationship: regulates GO:0001768 ! establishment of T cell polarity + +[Term] +id: GO:1903904 +name: negative regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "down regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "down regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "down regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of T cell polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T-cell polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "inhibition of T cell polarization" NARROW [GOC:TermGenie] +synonym: "inhibition of T lymphocyte polarization" NARROW [GOC:TermGenie] +synonym: "inhibition of T-cell polarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "negative regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "negative regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "negative regulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:0050868 ! negative regulation of T cell activation +is_a: GO:1903903 ! regulation of establishment of T cell polarity +relationship: negatively_regulates GO:0001768 ! establishment of T cell polarity + +[Term] +id: GO:1903905 +name: positive regulation of establishment of T cell polarity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "activation of establishment of T cell polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T-cell polarity" NARROW [GOC:TermGenie] +synonym: "activation of establishment of T-lymphocyte polarity" NARROW [GOC:TermGenie] +synonym: "activation of T cell polarization" NARROW [GOC:TermGenie] +synonym: "activation of T lymphocyte polarization" NARROW [GOC:TermGenie] +synonym: "activation of T-cell polarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "positive regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "positive regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "positive regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "up regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "up-regulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of T-cell polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T cell polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T-cell polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of T-lymphocyte polarity" EXACT [GOC:TermGenie] +synonym: "upregulation of T cell polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of T lymphocyte polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of T-cell polarization" EXACT [GOC:TermGenie] +is_a: GO:0050870 ! positive regulation of T cell activation +is_a: GO:1903903 ! regulation of establishment of T cell polarity +relationship: positively_regulates GO:0001768 ! establishment of T cell polarity + +[Term] +id: GO:1903906 +name: regulation of plasma membrane raft polarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:1903729 ! regulation of plasma membrane organization +relationship: regulates GO:0044858 ! plasma membrane raft polarization + +[Term] +id: GO:1903907 +name: negative regulation of plasma membrane raft polarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "down regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +synonym: "downregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +synonym: "inhibition of plasma membrane raft polarization" NARROW [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1903906 ! regulation of plasma membrane raft polarization +relationship: negatively_regulates GO:0044858 ! plasma membrane raft polarization + +[Term] +id: GO:1903908 +name: positive regulation of plasma membrane raft polarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasma membrane raft polarization." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "activation of plasma membrane raft polarization" NARROW [GOC:TermGenie] +synonym: "up regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +synonym: "upregulation of plasma membrane raft polarization" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903906 ! regulation of plasma membrane raft polarization +relationship: positively_regulates GO:0044858 ! plasma membrane raft polarization + +[Term] +id: GO:1903909 +name: regulation of receptor clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:0043113 ! receptor clustering + +[Term] +id: GO:1903910 +name: negative regulation of receptor clustering +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "down regulation of receptor clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor clustering" EXACT [GOC:TermGenie] +synonym: "inhibition of receptor clustering" NARROW [GOC:TermGenie] +is_a: GO:1903909 ! regulation of receptor clustering +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:0043113 ! receptor clustering + +[Term] +id: GO:1903911 +name: positive regulation of receptor clustering +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor clustering." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "activation of receptor clustering" NARROW [GOC:TermGenie] +synonym: "up regulation of receptor clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1903909 ! regulation of receptor clustering +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:0043113 ! receptor clustering + +[Term] +id: GO:1903912 +name: negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum stress-induced eiF2alpha phosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16835242] +synonym: "down regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "downregulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "inhibition of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "inhibition of eiF2alpha phosphorylation in response to ER stress" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "negative regulation of eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [] +synonym: "negative regulation of eiF2alpha phosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "negative regulation of ER stress-induced eIF2 alpha phosphorylation" EXACT [GOC:bf] +synonym: "negative regulation of regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0006446 ! regulation of translational initiation +relationship: negatively_regulates GO:0036492 ! eiF2alpha phosphorylation in response to endoplasmic reticulum stress + +[Term] +id: GO:1903913 +name: regulation of fusion of virus membrane with host plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "regulation of viral envelope fusion" BROAD [GOC:TermGenie] +synonym: "regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +is_a: GO:0046596 ! regulation of viral entry into host cell +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0019064 ! fusion of virus membrane with host plasma membrane + +[Term] +id: GO:1903914 +name: negative regulation of fusion of virus membrane with host plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "down regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "down regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "down regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "down-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "downregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "downregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "inhibition of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "inhibition of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of viral envelope fusion with host membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of viral penetration via membrane fusion" NARROW [GOC:TermGenie] +synonym: "inhibition of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "negative regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +is_a: GO:0046597 ! negative regulation of viral entry into host cell +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane +relationship: negatively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane + +[Term] +id: GO:1903915 +name: positive regulation of fusion of virus membrane with host plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23575248] +synonym: "activation of fusion of virus membrane with host plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "activation of viral envelope fusion with host cell membrane" NARROW [GOC:TermGenie] +synonym: "activation of viral envelope fusion with host membrane" NARROW [GOC:TermGenie] +synonym: "activation of viral envelope fusion with host plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of viral penetration via membrane fusion" NARROW [GOC:TermGenie] +synonym: "activation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "positive regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "up regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "up regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "up-regulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +synonym: "upregulation of fusion of virus membrane with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:TermGenie] +synonym: "upregulation of viral envelope fusion with host cell membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of viral envelope fusion with host membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of viral envelope fusion with host plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of viral penetration via membrane fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of viral-cell fusion molecule activity" RELATED [GOC:TermGenie] +is_a: GO:0046598 ! positive regulation of viral entry into host cell +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903913 ! regulation of fusion of virus membrane with host plasma membrane +relationship: positively_regulates GO:0019064 ! fusion of virus membrane with host plasma membrane + +[Term] +id: GO:1903916 +name: regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [] +synonym: "regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf] +synonym: "regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:0032535 ! regulation of cellular component size +is_a: GO:0035304 ! regulation of protein dephosphorylation +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress + +[Term] +id: GO:1903917 +name: positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum stress-induced eIF2alpha dephosphorylation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] +synonym: "activation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "activation of eIF2alpha dephosphorylation in response to ER stress" NARROW [GOC:TermGenie] +synonym: "activation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" RELATED [] +synonym: "positive regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER stress-induced eIF2 alpha dephosphorylation" EXACT [GOC:bf] +synonym: "positive regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "up regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of eIF2alpha dephosphorylation in response to ER stress" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +is_a: GO:0035307 ! positive regulation of protein dephosphorylation +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1903916 ! regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation +relationship: positively_regulates GO:0036497 ! eIF2alpha dephosphorylation in response to endoplasmic reticulum stress + +[Term] +id: GO:1903918 +name: regulation of actin filament severing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "regulation of F-actin severing" EXACT [GOC:TermGenie] +is_a: GO:0032970 ! regulation of actin filament-based process +relationship: regulates GO:0051014 ! actin filament severing + +[Term] +id: GO:1903919 +name: negative regulation of actin filament severing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "down regulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "down regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "down regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "down regulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "downregulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "downregulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "downregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "downregulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "inhibition of actin filament severing" NARROW [GOC:TermGenie] +synonym: "inhibition of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "inhibition of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "inhibition of F-actin severing" NARROW [GOC:TermGenie] +synonym: "negative regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of F-actin severing" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903918 ! regulation of actin filament severing +relationship: negatively_regulates GO:0051014 ! actin filament severing + +[Term] +id: GO:1903920 +name: positive regulation of actin filament severing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament severing." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "activation of actin filament severing" NARROW [GOC:TermGenie] +synonym: "activation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "activation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "activation of F-actin severing" NARROW [GOC:TermGenie] +synonym: "positive regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "up regulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "up regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "up regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "up regulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of F-actin severing" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament severing" EXACT [GOC:TermGenie] +synonym: "upregulation of actin filament severing activity" RELATED [GOC:TermGenie] +synonym: "upregulation of barbed-end actin capping/severing activity" RELATED [GOC:TermGenie] +synonym: "upregulation of F-actin severing" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903918 ! regulation of actin filament severing +relationship: positively_regulates GO:0051014 ! actin filament severing + +[Term] +id: GO:1903921 +name: regulation of protein processing in phagocytic vesicle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +is_a: GO:0070613 ! regulation of protein processing +relationship: regulates GO:1900756 ! protein processing in phagocytic vesicle + +[Term] +id: GO:1903922 +name: negative regulation of protein processing in phagocytic vesicle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "down regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "down regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "down regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "down regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "down regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "down-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "downregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "downregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "downregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "downregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "downregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "inhibition of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "inhibition of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "inhibition of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "inhibition of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "inhibition of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein processing in phagosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "negative regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +is_a: GO:0010955 ! negative regulation of protein processing +is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle +relationship: negatively_regulates GO:1900756 ! protein processing in phagocytic vesicle + +[Term] +id: GO:1903923 +name: positive regulation of protein processing in phagocytic vesicle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein processing in phagocytic vesicle." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23325791] +synonym: "activation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "activation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "activation of protein maturation by peptide bond cleavage in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein maturation by peptide bond cleavage in phagosome" NARROW [GOC:TermGenie] +synonym: "activation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein maturation by peptide bond hydrolysis in phagosome" NARROW [GOC:TermGenie] +synonym: "activation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "activation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "activation of protein processing in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein processing in phagosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "positive regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "up regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "up regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "up regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "up regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "up regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "up-regulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein processing in phagosome" EXACT [GOC:TermGenie] +synonym: "upregulation of peptidolysis during protein maturation in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "upregulation of peptidolysis during protein maturation in phagosome" RELATED [GOC:TermGenie] +synonym: "upregulation of protein maturation by peptide bond cleavage in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation by peptide bond cleavage in phagosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation by peptide bond hydrolysis in phagosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein maturation by proteolysis in phagocytic vesicle" RELATED [GOC:TermGenie] +synonym: "upregulation of protein maturation by proteolysis in phagosome" RELATED [GOC:TermGenie] +synonym: "upregulation of protein processing in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein processing in phagosome" EXACT [GOC:TermGenie] +is_a: GO:0010954 ! positive regulation of protein processing +is_a: GO:1903921 ! regulation of protein processing in phagocytic vesicle +relationship: positively_regulates GO:1900756 ! protein processing in phagocytic vesicle + +[Term] +id: GO:1903924 +name: estradiol binding +namespace: molecular_function +def: "Binding to estradiol." [GO_REF:0000067, GOC:TermGenie, PMID:9048584] +is_a: GO:0005496 ! steroid binding + +[Term] +id: GO:1903925 +name: response to bisphenol A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903926 +name: cellular response to bisphenol A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bisphenol A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22957036] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1903925 ! response to bisphenol A + +[Term] +id: GO:1903927 +name: response to cyanide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1903928 +name: cellular response to cyanide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyanide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21854848] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1903927 ! response to cyanide + +[Term] +id: GO:1903929 +name: primary palate development +namespace: biological_process +def: "The process whose specific outcome is the progression of a primary palate over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mgi_curators, GOC:TermGenie, PMID:24644145, PMID:25504820] +synonym: "palatum primarium development" RELATED [GOC:TermGenie] +synonym: "primary palate process development" EXACT [GOC:TermGenie] +synonym: "primitive palate development" RELATED [GOC:TermGenie] +synonym: "processus palatinus medianus development" RELATED [GOC:TermGenie] +is_a: GO:0060021 ! roof of mouth development + +[Term] +id: GO:1903930 +name: regulation of pyrimidine-containing compound salvage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302] +synonym: "regulation of pyrimidine salvage" RELATED [GOC:TermGenie] +is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0008655 ! pyrimidine-containing compound salvage + +[Term] +id: GO:1903931 +name: positive regulation of pyrimidine-containing compound salvage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pyrimidine-containing compound salvage." [GO_REF:0000058, GOC:TermGenie, PMID:23695302] +synonym: "activation of pyrimidine salvage" RELATED [GOC:TermGenie] +synonym: "activation of pyrimidine-containing compound salvage" NARROW [GOC:TermGenie] +synonym: "positive regulation of pyrimidine salvage" RELATED [GOC:TermGenie] +synonym: "up regulation of pyrimidine salvage" RELATED [GOC:TermGenie] +synonym: "up regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine salvage" RELATED [GOC:TermGenie] +synonym: "up-regulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine salvage" RELATED [GOC:TermGenie] +synonym: "upregulation of pyrimidine-containing compound salvage" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process +is_a: GO:1903930 ! regulation of pyrimidine-containing compound salvage +relationship: positively_regulates GO:0008655 ! pyrimidine-containing compound salvage + +[Term] +id: GO:1903932 +name: regulation of DNA primase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1903933 +name: negative regulation of DNA primase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] +synonym: "down regulation of DNA primase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA primase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA primase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA primase activity" NARROW [GOC:TermGenie] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1902679 ! negative regulation of RNA biosynthetic process +is_a: GO:1903932 ! regulation of DNA primase activity + +[Term] +id: GO:1903934 +name: positive regulation of DNA primase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA primase activity." [GO_REF:0000059, GOC:TermGenie, PMID:14766746] +synonym: "activation of DNA primase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA primase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA primase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA primase activity" EXACT [GOC:TermGenie] +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1902680 ! positive regulation of RNA biosynthetic process +is_a: GO:1903932 ! regulation of DNA primase activity + +[Term] +id: GO:1903935 +name: response to sodium arsenite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:0046685 ! response to arsenic-containing substance +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:1903936 +name: cellular response to sodium arsenite +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18674524] +is_a: GO:0071243 ! cellular response to arsenic-containing substance +is_a: GO:1902075 ! cellular response to salt +is_a: GO:1903935 ! response to sodium arsenite + +[Term] +id: GO:1903937 +name: response to acrylamide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1903938 +name: cellular response to acrylamide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acrylamide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16292499] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1903937 ! response to acrylamide + +[Term] +id: GO:1903939 +name: regulation of TORC2 signaling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430] +synonym: "regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +is_a: GO:0032006 ! regulation of TOR signaling +relationship: regulates GO:0038203 ! TORC2 signaling + +[Term] +id: GO:1903940 +name: negative regulation of TORC2 signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:24247430] +synonym: "down regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of TORC2 signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of TORC2 signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of TORC2 signaling" EXACT [GOC:TermGenie] +synonym: "inhibition of TORC2 signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of TORC2 signaling" NARROW [GOC:TermGenie] +synonym: "negative regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +is_a: GO:0032007 ! negative regulation of TOR signaling +is_a: GO:1903939 ! regulation of TORC2 signaling +relationship: negatively_regulates GO:0038203 ! TORC2 signaling + +[Term] +id: GO:1903941 +name: negative regulation of respiratory gaseous exchange +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] +synonym: "down regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +synonym: "down-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +synonym: "downregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +synonym: "inhibition of respiratory gaseous exchange" NARROW [GOC:TermGenie] +is_a: GO:0043576 ! regulation of respiratory gaseous exchange +is_a: GO:0051241 ! negative regulation of multicellular organismal process +relationship: negatively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:1903942 +name: positive regulation of respiratory gaseous exchange +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange." [GO_REF:0000058, GOC:TermGenie, PMID:22819705] +synonym: "activation of respiratory gaseous exchange" NARROW [GOC:TermGenie] +synonym: "up regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +synonym: "up-regulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +synonym: "upregulation of respiratory gaseous exchange" EXACT [GOC:TermGenie] +is_a: GO:0043576 ! regulation of respiratory gaseous exchange +is_a: GO:0051240 ! positive regulation of multicellular organismal process +relationship: positively_regulates GO:0007585 ! respiratory gaseous exchange by respiratory system + +[Term] +id: GO:1903943 +name: regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:0097284 ! hepatocyte apoptotic process + +[Term] +id: GO:1903944 +name: negative regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "down regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +is_a: GO:1903943 ! regulation of hepatocyte apoptotic process +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +relationship: negatively_regulates GO:0097284 ! hepatocyte apoptotic process + +[Term] +id: GO:1903945 +name: positive regulation of hepatocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:8649852] +synonym: "activation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of hepatocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of hepatocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1903943 ! regulation of hepatocyte apoptotic process +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +relationship: positively_regulates GO:0097284 ! hepatocyte apoptotic process + +[Term] +id: GO:1903946 +name: negative regulation of ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "down regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +is_a: GO:0045759 ! negative regulation of action potential +is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential +is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction +relationship: negatively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential + +[Term] +id: GO:1903947 +name: positive regulation of ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "activation of ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0045760 ! positive regulation of action potential +is_a: GO:0098911 ! regulation of ventricular cardiac muscle cell action potential +is_a: GO:0106134 ! positive regulation of cardiac muscle cell contraction +relationship: positively_regulates GO:0086005 ! ventricular cardiac muscle cell action potential + +[Term] +id: GO:1903948 +name: negative regulation of atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "down regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] +is_a: GO:0045759 ! negative regulation of action potential +is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential +is_a: GO:0106135 ! negative regulation of cardiac muscle cell contraction +relationship: negatively_regulates GO:0086014 ! atrial cardiac muscle cell action potential + +[Term] +id: GO:1903949 +name: positive regulation of atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "activation of atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0045760 ! positive regulation of action potential +is_a: GO:0098910 ! regulation of atrial cardiac muscle cell action potential +relationship: positively_regulates GO:0086014 ! atrial cardiac muscle cell action potential + +[Term] +id: GO:1903950 +name: negative regulation of AV node cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "down regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of AV node cell action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "negative regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0045759 ! negative regulation of action potential +is_a: GO:0098904 ! regulation of AV node cell action potential +relationship: negatively_regulates GO:0086016 ! AV node cell action potential + +[Term] +id: GO:1903951 +name: positive regulation of AV node cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "activation of atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of AV node cell action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "positive regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of AV node cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0045760 ! positive regulation of action potential +is_a: GO:0098904 ! regulation of AV node cell action potential +relationship: positively_regulates GO:0086016 ! AV node cell action potential + +[Term] +id: GO:1903952 +name: regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1903953 +name: negative regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +is_a: GO:1903817 ! negative regulation of voltage-gated potassium channel activity +is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization + +[Term] +id: GO:1903954 +name: positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization." [GO_REF:0000059, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nc, GOC:TermGenie, PMID:25281747] +synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization" EXACT [GOC:TermGenie] +is_a: GO:1903818 ! positive regulation of voltage-gated potassium channel activity +is_a: GO:1903952 ! regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization +is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential + +[Term] +id: GO:1903955 +name: positive regulation of protein targeting to mitochondrion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24270810] +comment: An example of this is PINK1 in human (UniProt symbol Q9BXM7) in PMID:24270810 inferred from mutant phenotype. +synonym: "activation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "activation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "activation of protein import into mitochondrion" NARROW [GOC:TermGenie] +synonym: "activation of protein targeting to mitochondria" NARROW [GOC:TermGenie] +synonym: "activation of protein targeting to mitochondrion" NARROW [GOC:TermGenie] +synonym: "activation of protein-mitochondrial targeting" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "positive regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "up regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "up regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "up regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "up regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "up regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "up-regulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial protein import" RELATED [GOC:TermGenie] +synonym: "upregulation of mitochondrial translocation" RELATED [GOC:TermGenie] +synonym: "upregulation of protein import into mitochondrion" EXACT [GOC:TermGenie] +synonym: "upregulation of protein targeting to mitochondria" EXACT [GOC:TermGenie] +synonym: "upregulation of protein targeting to mitochondrion" EXACT [GOC:TermGenie] +synonym: "upregulation of protein-mitochondrial targeting" EXACT [GOC:TermGenie] +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1903214 ! regulation of protein targeting to mitochondrion +is_a: GO:1903749 ! positive regulation of establishment of protein localization to mitochondrion +relationship: positively_regulates GO:0006626 ! protein targeting to mitochondrion + +[Term] +id: GO:1903958 +name: nitric-oxide synthase complex +namespace: cellular_component +def: "A protein complex which is capable of nitric-oxide synthase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:25417112] +comment: An example of this is NOS2 in human (P35228) in PMID:25417112 (inferred from direct assay). +synonym: "iNOS-S100A8/A9 complex" NARROW [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1903959 +name: regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +is_a: GO:0034765 ! regulation of ion transmembrane transport +is_a: GO:0044070 ! regulation of anion transport +relationship: regulates GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1903960 +name: negative regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "down regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anion transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: negatively_regulates GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1903961 +name: positive regulation of anion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, GOC:vw] +synonym: "activation of anion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anion transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:1903959 ! regulation of anion transmembrane transport +relationship: positively_regulates GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1903962 +name: arachidonate transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of arachidonate from one side of a membrane to the other." [GO_REF:0000066, GOC:bhm, GOC:TermGenie, PMID:15642721] +comment: An example of this is S100A9 in human (P06702) in PMID:15642721 (inferred from direct assay). +synonym: "arachidonate transporter activity" RELATED [] +synonym: "arachidonic acid transporter activity" RELATED [] +is_a: GO:0005324 ! long-chain fatty acid transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0015245 ! fatty acid transmembrane transporter activity + +[Term] +id: GO:1903963 +name: arachidonate transport +namespace: biological_process +def: "The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:bhm, GOC:TermGenie, PMID:15642721] +synonym: "arachidonic acid transport" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015909 ! long-chain fatty acid transport +is_a: GO:0071715 ! icosanoid transport + +[Term] +id: GO:1903964 +name: monounsaturated fatty acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] +comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. +synonym: "monounsaturated fatty acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006082 ! organic acid metabolic process +is_a: GO:0006629 ! lipid metabolic process + +[Term] +id: GO:1903965 +name: monounsaturated fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] +synonym: "monounsaturated fatty acid breakdown" EXACT [GOC:TermGenie] +synonym: "monounsaturated fatty acid catabolism" EXACT [GOC:TermGenie] +synonym: "monounsaturated fatty acid degradation" EXACT [GOC:TermGenie] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0016054 ! organic acid catabolic process +is_a: GO:1903964 ! monounsaturated fatty acid metabolic process + +[Term] +id: GO:1903966 +name: monounsaturated fatty acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of monounsaturated fatty acid." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:16443825] +comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. +synonym: "monounsaturated fatty acid anabolism" EXACT [GOC:TermGenie] +synonym: "monounsaturated fatty acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "monounsaturated fatty acid formation" EXACT [GOC:TermGenie] +synonym: "monounsaturated fatty acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008610 ! lipid biosynthetic process +is_a: GO:0016053 ! organic acid biosynthetic process +is_a: GO:1903964 ! monounsaturated fatty acid metabolic process + +[Term] +id: GO:1903967 +name: response to micafungin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] +is_a: GO:0033993 ! response to lipid +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:1903968 +name: cellular response to micafungin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a micafungin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16928959] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901653 ! cellular response to peptide +is_a: GO:1903967 ! response to micafungin + +[Term] +id: GO:1903969 +name: regulation of response to macrophage colony-stimulating factor +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +is_a: GO:0060759 ! regulation of response to cytokine stimulus +relationship: regulates GO:0036005 ! response to macrophage colony-stimulating factor + +[Term] +id: GO:1903970 +name: negative regulation of response to macrophage colony-stimulating factor +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "down regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "down regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "downregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "downregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of response to M-CSF" NARROW [GOC:TermGenie] +synonym: "inhibition of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] +synonym: "inhibition of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] +synonym: "negative regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "negative regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +is_a: GO:0060761 ! negative regulation of response to cytokine stimulus +is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor +relationship: negatively_regulates GO:0036005 ! response to macrophage colony-stimulating factor + +[Term] +id: GO:1903971 +name: positive regulation of response to macrophage colony-stimulating factor +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to macrophage colony-stimulating factor." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of response to M-CSF" NARROW [GOC:TermGenie] +synonym: "activation of response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] +synonym: "activation of response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "up regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "up regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of response to M-CSF" EXACT [GOC:TermGenie] +synonym: "upregulation of response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "upregulation of response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +is_a: GO:0060760 ! positive regulation of response to cytokine stimulus +is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor +relationship: positively_regulates GO:0036005 ! response to macrophage colony-stimulating factor + +[Term] +id: GO:1903972 +name: regulation of cellular response to macrophage colony-stimulating factor stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:1903969 ! regulation of response to macrophage colony-stimulating factor +relationship: regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus + +[Term] +id: GO:1903973 +name: negative regulation of cellular response to macrophage colony-stimulating factor stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903970 ! negative regulation of response to macrophage colony-stimulating factor +is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus +relationship: negatively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus + +[Term] +id: GO:1903974 +name: positive regulation of cellular response to macrophage colony-stimulating factor stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to macrophage colony-stimulating factor stimulus." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of cellular response to M-CSF stimulus" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to macrophage colony-stimulating factor" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to macrophage colony-stimulating factor stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to M-CSF stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to macrophage colony-stimulating factor" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to macrophage colony-stimulating factor stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903971 ! positive regulation of response to macrophage colony-stimulating factor +is_a: GO:1903972 ! regulation of cellular response to macrophage colony-stimulating factor stimulus +relationship: positively_regulates GO:0036006 ! cellular response to macrophage colony-stimulating factor stimulus + +[Term] +id: GO:1903975 +name: regulation of glial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "regulation of glia cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0008347 ! glial cell migration + +[Term] +id: GO:1903976 +name: negative regulation of glial cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "down regulation of glial cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of glial cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of glial cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of glia cell migration" NARROW [GOC:TermGenie] +synonym: "inhibition of glial cell migration" NARROW [GOC:TermGenie] +synonym: "negative regulation of glia cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:1903975 ! regulation of glial cell migration +relationship: negatively_regulates GO:0008347 ! glial cell migration + +[Term] +id: GO:1903977 +name: positive regulation of glial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of glia cell migration" NARROW [GOC:TermGenie] +synonym: "activation of glial cell migration" NARROW [GOC:TermGenie] +synonym: "positive regulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "up regulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "up regulation of glial cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of glial cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of glia cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of glial cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:1903975 ! regulation of glial cell migration +relationship: positively_regulates GO:0008347 ! glial cell migration + +[Term] +id: GO:1903978 +name: regulation of microglial cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +is_a: GO:0043030 ! regulation of macrophage activation +is_a: GO:0150077 ! regulation of neuroinflammatory response +relationship: regulates GO:0001774 ! microglial cell activation + +[Term] +id: GO:1903979 +name: negative regulation of microglial cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of microglial cell activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of microglial cell activation" EXACT [GOC:TermGenie] +synonym: "downregulation of microglial cell activation" EXACT [GOC:TermGenie] +synonym: "inhibition of microglial cell activation" NARROW [GOC:TermGenie] +is_a: GO:0043031 ! negative regulation of macrophage activation +is_a: GO:0150079 ! negative regulation of neuroinflammatory response +is_a: GO:1903978 ! regulation of microglial cell activation +relationship: negatively_regulates GO:0001774 ! microglial cell activation + +[Term] +id: GO:1903980 +name: positive regulation of microglial cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microglial cell activation." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of microglial cell activation" NARROW [GOC:TermGenie] +synonym: "up regulation of microglial cell activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of microglial cell activation" EXACT [GOC:TermGenie] +synonym: "upregulation of microglial cell activation" EXACT [GOC:TermGenie] +is_a: GO:0043032 ! positive regulation of macrophage activation +is_a: GO:0150078 ! positive regulation of neuroinflammatory response +is_a: GO:1903978 ! regulation of microglial cell activation +relationship: positively_regulates GO:0001774 ! microglial cell activation + +[Term] +id: GO:1903981 +name: enterobactin binding +namespace: molecular_function +def: "Binding to enterobactin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:21951132] +synonym: "enterochelin binding" EXACT [] +synonym: "siderophore binding" BROAD [] +is_a: GO:0005527 ! macrolide binding +is_a: GO:0043168 ! anion binding + +[Term] +id: GO:1903982 +name: negative regulation of microvillus length +namespace: biological_process +def: "A process that decreases the length of a microvillus." [GOC:als, PMID:22114352] +synonym: "down regulation of regulation of microvillus length" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of microvillus length" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of microvillus length" EXACT [GOC:TermGenie] +synonym: "inhibition of regulation of microvillus length" NARROW [GOC:TermGenie] +is_a: GO:0031345 ! negative regulation of cell projection organization +is_a: GO:0032532 ! regulation of microvillus length + +[Term] +id: GO:1903983 +name: positive regulation of microvillus length +namespace: biological_process +def: "A process that increases the length of a microvillus." [GOC:als, PMID:22114352] +synonym: "activation of regulation of microvillus length" NARROW [GOC:TermGenie] +synonym: "up regulation of regulation of microvillus length" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of microvillus length" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of microvillus length" EXACT [GOC:TermGenie] +is_a: GO:0031346 ! positive regulation of cell projection organization +is_a: GO:0032532 ! regulation of microvillus length + +[Term] +id: GO:1903984 +name: positive regulation of TRAIL-activated apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24939851] +synonym: "activation of TRAIL-activated apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of TRAIL-activated extrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of TRAIL-induced apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of TRAIL-activated apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of TRAIL-activated extrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of TRAIL-induced apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors +is_a: GO:1903121 ! regulation of TRAIL-activated apoptotic signaling pathway +relationship: positively_regulates GO:0036462 ! TRAIL-activated apoptotic signaling pathway + +[Term] +id: GO:1903985 +name: regulation of intestinal D-glucose absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intestinal D-glucose absorption." [GO_REF:0000058, GOA:als, GOC:TermGenie, PMID:22114352] +is_a: GO:1904478 ! regulation of intestinal absorption +relationship: regulates GO:0001951 ! intestinal D-glucose absorption + +[Term] +id: GO:1903988 +name: iron ion export across plasma membrane +namespace: biological_process +alt_id: GO:1903414 +def: "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116] +comment: An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9). +synonym: "ferrous iron export" NARROW [] +synonym: "ferrous iron export across plasma membrane" NARROW [] +synonym: "iron cation export" RELATED [] +synonym: "iron(2+) export" RELATED [] +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:0070839 ! metal ion export +is_a: GO:0140115 ! export across plasma membrane + +[Term] +id: GO:1903992 +name: obsolete regulation of protein stabilization +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] +comment: This term was made obsolete because it was created in error. +synonym: "regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "regulation of protein stabilization" EXACT [] +synonym: "regulation of protein stabilization activity" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0031647 + +[Term] +id: GO:1903993 +name: obsolete negative regulation of protein stabilization +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] +comment: This term was made obsolete because it was created in error. +synonym: "down regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "down regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "down regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "down regulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "down regulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "down-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "downregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "downregulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "downregulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "downregulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "downregulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "inhibition of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "inhibition of positive regulation of protein stability" NARROW [GOC:TermGenie] +synonym: "inhibition of protein sequestering" RELATED [GOC:TermGenie] +synonym: "inhibition of protein stabilization" NARROW [GOC:TermGenie] +synonym: "inhibition of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "negative regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein stabilization" EXACT [] +synonym: "negative regulation of protein stabilization activity" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0031648 + +[Term] +id: GO:1903994 +name: obsolete positive regulation of protein stabilization +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of protein stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:18573880] +comment: This term was made obsolete because it was created in error. +synonym: "activation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "activation of positive regulation of protein stability" NARROW [GOC:TermGenie] +synonym: "activation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "activation of protein stabilization" NARROW [GOC:TermGenie] +synonym: "activation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "positive regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein stabilization" EXACT [] +synonym: "positive regulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "up regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "up regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "up regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "up regulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "up regulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "up-regulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein stabilization activity" RELATED [GOC:TermGenie] +synonym: "upregulation of lysosomal protein stabilization" NARROW [GOC:TermGenie] +synonym: "upregulation of positive regulation of protein stability" EXACT [GOC:TermGenie] +synonym: "upregulation of protein sequestering" RELATED [GOC:TermGenie] +synonym: "upregulation of protein stabilization" EXACT [GOC:TermGenie] +synonym: "upregulation of protein stabilization activity" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0050821 + +[Term] +id: GO:1903995 +name: regulation of non-membrane spanning protein tyrosine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] +synonym: "regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:protein-tyrosine O-phosphotransferase activity" BROAD [GOC:TermGenie] +synonym: "regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +is_a: GO:0061097 ! regulation of protein tyrosine kinase activity + +[Term] +id: GO:1903996 +name: negative regulation of non-membrane spanning protein tyrosine kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] +synonym: "down regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity +is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity + +[Term] +id: GO:1903997 +name: positive regulation of non-membrane spanning protein tyrosine kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:10518561] +synonym: "activation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" NARROW [GOC:TermGenie] +synonym: "activation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "activation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "activation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "activation of non-membrane spanning protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of non-specific protein-tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "up regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "up regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "up regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of Bruton's tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of cytoplasmic protein tyrosine kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of focal adhesion kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of janus kinase 1 activity" NARROW [GOC:TermGenie] +synonym: "upregulation of janus kinase 2 activity" NARROW [GOC:TermGenie] +synonym: "upregulation of janus kinase 3 activity" NARROW [GOC:TermGenie] +synonym: "upregulation of non-membrane spanning protein tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of non-specific protein-tyrosine kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of p60c-src protein tyrosine kinase activity" NARROW [GOC:TermGenie] +is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity +is_a: GO:1903995 ! regulation of non-membrane spanning protein tyrosine kinase activity + +[Term] +id: GO:1903998 +name: regulation of eating behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] +synonym: "regulation of eating behaviour" EXACT [GOC:TermGenie] +is_a: GO:0060259 ! regulation of feeding behavior +relationship: regulates GO:0042755 ! eating behavior + +[Term] +id: GO:1903999 +name: negative regulation of eating behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] +synonym: "down regulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "down regulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "down-regulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "down-regulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "downregulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "downregulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "inhibition of eating behavior" NARROW [GOC:TermGenie] +synonym: "inhibition of eating behaviour" NARROW [GOC:TermGenie] +synonym: "negative regulation of eating behaviour" EXACT [GOC:TermGenie] +is_a: GO:1903998 ! regulation of eating behavior +is_a: GO:2000252 ! negative regulation of feeding behavior +relationship: negatively_regulates GO:0042755 ! eating behavior + +[Term] +id: GO:1904000 +name: positive regulation of eating behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eating behavior." [GO_REF:0000058, GOC:TermGenie, PMID:11961051] +synonym: "activation of eating behavior" NARROW [GOC:TermGenie] +synonym: "activation of eating behaviour" NARROW [GOC:TermGenie] +synonym: "positive regulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "up regulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "up regulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "up-regulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "up-regulation of eating behaviour" EXACT [GOC:TermGenie] +synonym: "upregulation of eating behavior" EXACT [GOC:TermGenie] +synonym: "upregulation of eating behaviour" EXACT [GOC:TermGenie] +is_a: GO:1903998 ! regulation of eating behavior +is_a: GO:2000253 ! positive regulation of feeding behavior +relationship: positively_regulates GO:0042755 ! eating behavior + +[Term] +id: GO:1904001 +name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [GO_REF:0000063, GOC:al, GOC:TermGenie, PMID:23695302] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "activation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "up-regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of pyrimidine salvage by positive regulation of transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "upregulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904002 +name: regulation of sebum secreting cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] +synonym: "regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:1990654 ! sebum secreting cell proliferation + +[Term] +id: GO:1904003 +name: negative regulation of sebum secreting cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] +synonym: "down regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "down regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "down-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "downregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "inhibition of sebum secreting cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1904002 ! regulation of sebum secreting cell proliferation +relationship: negatively_regulates GO:1990654 ! sebum secreting cell proliferation + +[Term] +id: GO:1904004 +name: positive regulation of sebum secreting cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sebum secreting cell proliferation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:16901790] +synonym: "activation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "activation of sebum secreting cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "up regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "up regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "up-regulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of sebocyte proliferation" RELATED [GOC:TermGenie] +synonym: "upregulation of sebum secreting cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1904002 ! regulation of sebum secreting cell proliferation +relationship: positively_regulates GO:1990654 ! sebum secreting cell proliferation + +[Term] +id: GO:1904005 +name: regulation of phospholipase D activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] +synonym: "regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0010517 ! regulation of phospholipase activity + +[Term] +id: GO:1904006 +name: negative regulation of phospholipase D activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] +synonym: "down regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "down regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phospholipase D activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phospholipase D activity" EXACT [GOC:TermGenie] +synonym: "downregulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "downregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phospholipase D activity" EXACT [GOC:TermGenie] +synonym: "inhibition of choline phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of lecithinase D activity" NARROW [GOC:TermGenie] +synonym: "inhibition of lipophosphodiesterase II activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phospholipase D activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0010519 ! negative regulation of phospholipase activity +is_a: GO:1904005 ! regulation of phospholipase D activity + +[Term] +id: GO:1904007 +name: positive regulation of phospholipase D activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipase D activity." [GO_REF:0000059, GOC:TermGenie, PMID:11211872] +synonym: "activation of choline phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of lecithinase D activity" NARROW [GOC:TermGenie] +synonym: "activation of lipophosphodiesterase II activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylcholine phosphatidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of phospholipase D activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "up regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phospholipase D activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phospholipase D activity" EXACT [GOC:TermGenie] +synonym: "upregulation of choline phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of lecithinase D activity" EXACT [GOC:TermGenie] +synonym: "upregulation of lipophosphodiesterase II activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylcholine phosphatidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phospholipase D activity" EXACT [GOC:TermGenie] +is_a: GO:0010518 ! positive regulation of phospholipase activity +is_a: GO:1904005 ! regulation of phospholipase D activity + +[Term] +id: GO:1904008 +name: response to monosodium glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590] +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:1904009 +name: cellular response to monosodium glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20704590] +is_a: GO:1902075 ! cellular response to salt +is_a: GO:1904008 ! response to monosodium glutamate + +[Term] +id: GO:1904010 +name: response to Aroclor 1254 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1904011 +name: cellular response to Aroclor 1254 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an Aroclor 1254 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18602130] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904010 ! response to Aroclor 1254 + +[Term] +id: GO:1904012 +name: obsolete platinum binding +namespace: molecular_function +def: "OBSOLETE. Binding to platinum." [GO_REF:0000067, GOC:TermGenie, PMID:10089464] +comment: The reason for obsoletion is that binding to platinum does not have physiological relevance. +is_obsolete: true + +[Term] +id: GO:1904013 +name: obsolete xenon atom binding +namespace: molecular_function +def: "OBSOLETE. Binding to xenon atom." [GO_REF:0000067, GOC:TermGenie, PMID:10089464] +comment: The reason for obsoletion is that binding to xenon does not have physiological relevance. +is_obsolete: true + +[Term] +id: GO:1904014 +name: response to serotonin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0071867 ! response to monoamine +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904015 +name: cellular response to serotonin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1505525] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071868 ! cellular response to monoamine stimulus +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904014 ! response to serotonin + +[Term] +id: GO:1904016 +name: response to Thyroglobulin triiodothyronine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1904017 +name: cellular response to Thyroglobulin triiodothyronine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroglobulin triiodothyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7531505] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904016 ! response to Thyroglobulin triiodothyronine + +[Term] +id: GO:1904018 +name: positive regulation of vasculature development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vasculature development." [GO_REF:0000058, GOC:TermGenie, PMID:21472453] +synonym: "activation of vascular system development" RELATED [GOC:TermGenie] +synonym: "activation of vasculature development" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "up regulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "up regulation of vasculature development" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "up-regulation of vasculature development" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular system development" RELATED [GOC:TermGenie] +synonym: "upregulation of vasculature development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901342 ! regulation of vasculature development +relationship: positively_regulates GO:0001944 ! vasculature development + +[Term] +id: GO:1904019 +name: epithelial cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an epithelial cell." [GO_REF:0000085, GOC:TermGenie, PMID:19137015] +synonym: "epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1904020 +name: regulation of G protein-coupled receptor internalization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] +synonym: "regulation of G-protein-coupled receptor internalization" EXACT [] +is_a: GO:0002090 ! regulation of receptor internalization +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0002031 ! G protein-coupled receptor internalization + +[Term] +id: GO:1904021 +name: negative regulation of G protein-coupled receptor internalization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] +synonym: "down regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +synonym: "downregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +synonym: "inhibition of G-protein coupled receptor internalization" NARROW [GOC:TermGenie] +synonym: "negative regulation of G-protein coupled receptor internalization" EXACT [] +is_a: GO:0002091 ! negative regulation of receptor internalization +is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization +relationship: negatively_regulates GO:0002031 ! G protein-coupled receptor internalization + +[Term] +id: GO:1904022 +name: positive regulation of G protein-coupled receptor internalization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor internalization." [GO_REF:0000058, GOC:TermGenie, PMID:24732013] +synonym: "activation of G-protein coupled receptor internalization" NARROW [GOC:TermGenie] +synonym: "positive regulation of G-protein coupled receptor internalization" EXACT [] +synonym: "up regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +synonym: "upregulation of G-protein coupled receptor internalization" EXACT [GOC:TermGenie] +is_a: GO:0002092 ! positive regulation of receptor internalization +is_a: GO:1904020 ! regulation of G protein-coupled receptor internalization +relationship: positively_regulates GO:0002031 ! G protein-coupled receptor internalization + +[Term] +id: GO:1904023 +name: regulation of glucose catabolic process to lactate via pyruvate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] +synonym: "regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "regulation of homolactic fermentation" EXACT [GOC:TermGenie] +is_a: GO:0010906 ! regulation of glucose metabolic process +is_a: GO:0043465 ! regulation of fermentation +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:1902688 ! regulation of NAD metabolic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate + +[Term] +id: GO:1904024 +name: negative regulation of glucose catabolic process to lactate via pyruvate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] +synonym: "down regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "down regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "down regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "down regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "down regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "down regulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "down-regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "down-regulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "downregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "downregulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "downregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "downregulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "downregulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "inhibition of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie] +synonym: "inhibition of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie] +synonym: "inhibition of homofermentation" NARROW [GOC:TermGenie] +synonym: "inhibition of homofermentative lactate fermentation" NARROW [GOC:TermGenie] +synonym: "inhibition of homofermentative pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of homolactate fermentation" NARROW [GOC:TermGenie] +synonym: "inhibition of homolactic fermentation" NARROW [GOC:TermGenie] +synonym: "negative regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "negative regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "negative regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "negative regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "negative regulation of homolactic fermentation" EXACT [GOC:TermGenie] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1901003 ! negative regulation of fermentation +is_a: GO:1902689 ! negative regulation of NAD metabolic process +is_a: GO:1903579 ! negative regulation of ATP metabolic process +is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate +relationship: negatively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate + +[Term] +id: GO:1904025 +name: positive regulation of glucose catabolic process to lactate via pyruvate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to lactate via pyruvate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:20935145] +synonym: "activation of glucose catabolic process to lactate via pyruvate" NARROW [GOC:TermGenie] +synonym: "activation of glucose fermentation to lactate via pyruvate" NARROW [GOC:TermGenie] +synonym: "activation of homofermentation" NARROW [GOC:TermGenie] +synonym: "activation of homofermentative lactate fermentation" NARROW [GOC:TermGenie] +synonym: "activation of homofermentative pathway" NARROW [GOC:TermGenie] +synonym: "activation of homolactate fermentation" NARROW [GOC:TermGenie] +synonym: "activation of homolactic fermentation" NARROW [GOC:TermGenie] +synonym: "positive regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "positive regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "positive regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "positive regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "positive regulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "up regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "up regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "up regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "up regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "up regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "up regulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "up-regulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "up-regulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "up-regulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "up-regulation of homolactic fermentation" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose catabolic process to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "upregulation of glucose fermentation to lactate via pyruvate" EXACT [GOC:TermGenie] +synonym: "upregulation of homofermentation" EXACT [GOC:TermGenie] +synonym: "upregulation of homofermentative lactate fermentation" EXACT [GOC:TermGenie] +synonym: "upregulation of homofermentative pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of homolactate fermentation" EXACT [GOC:TermGenie] +synonym: "upregulation of homolactic fermentation" EXACT [GOC:TermGenie] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010907 ! positive regulation of glucose metabolic process +is_a: GO:1902690 ! positive regulation of NAD metabolic process +is_a: GO:1903580 ! positive regulation of ATP metabolic process +is_a: GO:1904023 ! regulation of glucose catabolic process to lactate via pyruvate +relationship: positively_regulates GO:0019661 ! glucose catabolic process to lactate via pyruvate + +[Term] +id: GO:1904026 +name: regulation of collagen fibril organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] +synonym: "regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "regulation of collagen fibrillogenesis" RELATED [] +synonym: "regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +is_a: GO:1902903 ! regulation of supramolecular fiber organization +is_a: GO:1903053 ! regulation of extracellular matrix organization +relationship: regulates GO:0030199 ! collagen fibril organization + +[Term] +id: GO:1904027 +name: negative regulation of collagen fibril organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] +synonym: "down regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "down regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "downregulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "downregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "inhibition of collagen fibril organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of collagen fibril organization" NARROW [GOC:TermGenie] +synonym: "inhibition of fibrillar collagen organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +is_a: GO:1903054 ! negative regulation of extracellular matrix organization +is_a: GO:1904026 ! regulation of collagen fibril organization +relationship: negatively_regulates GO:0030199 ! collagen fibril organization + +[Term] +id: GO:1904028 +name: positive regulation of collagen fibril organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of collagen fibril organization." [GO_REF:0000058, GOC:TermGenie, PMID:25451920] +synonym: "activation of collagen fibril organisation" NARROW [GOC:TermGenie] +synonym: "activation of collagen fibril organization" NARROW [GOC:TermGenie] +synonym: "activation of fibrillar collagen organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "up regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "up regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +synonym: "upregulation of collagen fibril organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of collagen fibril organization" EXACT [GOC:TermGenie] +synonym: "upregulation of fibrillar collagen organization" EXACT [GOC:TermGenie] +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +is_a: GO:1903055 ! positive regulation of extracellular matrix organization +is_a: GO:1904026 ! regulation of collagen fibril organization +relationship: positively_regulates GO:0030199 ! collagen fibril organization + +[Term] +id: GO:1904029 +name: regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] +is_a: GO:0045859 ! regulation of protein kinase activity +is_a: GO:0051726 ! regulation of cell cycle + +[Term] +id: GO:1904030 +name: negative regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] +synonym: "down regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0006469 ! negative regulation of protein kinase activity +is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:1904031 +name: positive regulation of cyclin-dependent protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:22995177] +synonym: "activation of cyclin-dependent protein kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclin-dependent protein kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0045860 ! positive regulation of protein kinase activity +is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity + +[Term] +id: GO:1904032 +name: regulation of t-SNARE clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:1990656 ! t-SNARE clustering + +[Term] +id: GO:1904033 +name: negative regulation of t-SNARE clustering +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] +synonym: "down regulation of t-SNARE clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of t-SNARE clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of t-SNARE clustering" EXACT [GOC:TermGenie] +synonym: "inhibition of t-SNARE clustering" NARROW [GOC:TermGenie] +is_a: GO:1904032 ! regulation of t-SNARE clustering +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:1990656 ! t-SNARE clustering + +[Term] +id: GO:1904034 +name: positive regulation of t-SNARE clustering +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of t-SNARE clustering." [GO_REF:0000058, GOC:TermGenie, PMID:22528485] +synonym: "activation of t-SNARE clustering" NARROW [GOC:TermGenie] +synonym: "up regulation of t-SNARE clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of t-SNARE clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of t-SNARE clustering" EXACT [GOC:TermGenie] +is_a: GO:1904032 ! regulation of t-SNARE clustering +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:1990656 ! t-SNARE clustering + +[Term] +id: GO:1904035 +name: regulation of epithelial cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] +synonym: "regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1904036 +name: negative regulation of epithelial cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] +synonym: "down regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of epithelial cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: negatively_regulates GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1904037 +name: positive regulation of epithelial cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19137015] +synonym: "activation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of epithelial cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of epitheliocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of epitheliocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of epitheliocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1904038 +name: regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "regulation of ferrous iron export" NARROW [] +synonym: "regulation of iron(2+) export" NARROW [] +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +relationship: regulates GO:1903988 ! iron ion export across plasma membrane + +[Term] +id: GO:1904039 +name: negative regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "down regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "down regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "down-regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "downregulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "downregulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron(2+) export" NARROW [] +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904038 ! regulation of iron export across plasma membrane +relationship: negatively_regulates GO:1903988 ! iron ion export across plasma membrane + +[Term] +id: GO:1904040 +name: positive regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron(2+) export" NARROW [] +synonym: "up regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "up regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "up-regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "upregulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "upregulation of iron(2+) export" NARROW [GOC:TermGenie] +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904038 ! regulation of iron export across plasma membrane +relationship: positively_regulates GO:1903988 ! iron ion export across plasma membrane + +[Term] +id: GO:1904041 +name: regulation of cystathionine beta-synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] +synonym: "regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:1904042 +name: negative regulation of cystathionine beta-synthase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] +synonym: "down regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "down regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "downregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of beta-thionase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cystathionine beta-synthase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie] +synonym: "inhibition of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of methylcysteine synthase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of serine sulfhydrase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of serine sulfhydrylase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051350 ! negative regulation of lyase activity +is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity + +[Term] +id: GO:1904043 +name: positive regulation of cystathionine beta-synthase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cystathionine beta-synthase activity." [GO_REF:0000059, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24416422] +synonym: "activation of beta-thionase activity" NARROW [GOC:TermGenie] +synonym: "activation of cystathionine beta-synthase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-serine hydro-lyase (adding homocysteine)" NARROW [GOC:TermGenie] +synonym: "activation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" NARROW [GOC:TermGenie] +synonym: "activation of methylcysteine synthase activity" NARROW [GOC:TermGenie] +synonym: "activation of serine sulfhydrase activity" NARROW [GOC:TermGenie] +synonym: "activation of serine sulfhydrylase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "up regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-thionase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cystathionine beta-synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-serine hydro-lyase (adding homocysteine)" EXACT [GOC:TermGenie] +synonym: "upregulation of L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of methylcysteine synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of serine sulfhydrase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of serine sulfhydrylase activity" EXACT [GOC:TermGenie] +is_a: GO:0051349 ! positive regulation of lyase activity +is_a: GO:1904041 ! regulation of cystathionine beta-synthase activity + +[Term] +id: GO:1904044 +name: response to aldosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] +is_a: GO:0051385 ! response to mineralocorticoid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904045 +name: cellular response to aldosterone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17644563] +is_a: GO:0071389 ! cellular response to mineralocorticoid stimulus +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:0110096 ! cellular response to aldehyde +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904044 ! response to aldosterone + +[Term] +id: GO:1904046 +name: negative regulation of vascular endothelial growth factor production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production." [GO_REF:0000058, GOC:TermGenie, PMID:19404486] +synonym: "down regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] +synonym: "down regulation of VEGF production" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] +synonym: "down-regulation of VEGF production" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular endothelial growth factor production" EXACT [GOC:TermGenie] +synonym: "downregulation of VEGF production" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular endothelial growth factor production" NARROW [GOC:TermGenie] +synonym: "inhibition of VEGF production" NARROW [GOC:TermGenie] +synonym: "negative regulation of VEGF production" EXACT [GOC:TermGenie] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:0010574 ! regulation of vascular endothelial growth factor production +relationship: negatively_regulates GO:0010573 ! vascular endothelial growth factor production + +[Term] +id: GO:1904047 +name: S-adenosyl-L-methionine binding +namespace: molecular_function +alt_id: GO:0070283 +def: "Binding to S-adenosyl-L-methionine." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361] +synonym: "radical SAM enzyme activity" NARROW [] +xref: Reactome:R-HSA-947535 "Cyclisation of GTP to precursor Z" +is_a: GO:0043169 ! cation binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:1904048 +name: regulation of spontaneous neurotransmitter secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] +comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). +synonym: "regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0150003 ! regulation of spontaneous synaptic transmission +relationship: regulates GO:0061669 ! spontaneous neurotransmitter secretion + +[Term] +id: GO:1904049 +name: negative regulation of spontaneous neurotransmitter secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] +comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). +synonym: "down regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion +relationship: negatively_regulates GO:0061669 ! spontaneous neurotransmitter secretion + +[Term] +id: GO:1904050 +name: positive regulation of spontaneous neurotransmitter secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spontaneous neurotransmitter secretion." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22314364] +comment: An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). +synonym: "activation of spontaneous neurotransmitter secretion" NARROW [GOC:TermGenie] +synonym: "activation of stimulus-independent neurotransmitter secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of spontaneous neurotransmitter secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of stimulus-independent neurotransmitter secretion" EXACT [GOC:TermGenie] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:1904048 ! regulation of spontaneous neurotransmitter secretion +relationship: positively_regulates GO:0061669 ! spontaneous neurotransmitter secretion + +[Term] +id: GO:1904051 +name: regulation of protein targeting to vacuole involved in autophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). +is_a: GO:1903335 ! regulation of vacuolar transport +is_a: GO:1903533 ! regulation of protein targeting +relationship: regulates GO:0071211 ! protein targeting to vacuole involved in autophagy + +[Term] +id: GO:1904052 +name: negative regulation of protein targeting to vacuole involved in autophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). +synonym: "down regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +synonym: "inhibition of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie] +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1903336 ! negative regulation of vacuolar transport +is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy +relationship: negatively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy + +[Term] +id: GO:1904053 +name: positive regulation of protein targeting to vacuole involved in autophagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein targeting to vacuole involved in autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +comment: An example of this is SMURF1 in human (UniProt symbol Q9HCE7) in PMID:22020285 (inferred from mutant phenotype). +synonym: "activation of protein targeting to vacuole involved in autophagy" NARROW [GOC:TermGenie] +synonym: "up regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of protein targeting to vacuole involved in autophagy" EXACT [GOC:TermGenie] +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1903337 ! positive regulation of vacuolar transport +is_a: GO:1904051 ! regulation of protein targeting to vacuole involved in autophagy +relationship: positively_regulates GO:0071211 ! protein targeting to vacuole involved in autophagy + +[Term] +id: GO:1904054 +name: regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:1990705 ! cholangiocyte proliferation + +[Term] +id: GO:1904055 +name: negative regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "down regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of cholangiocyte proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatoblast proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:1904054 ! regulation of cholangiocyte proliferation +relationship: negatively_regulates GO:1990705 ! cholangiocyte proliferation + +[Term] +id: GO:1904056 +name: positive regulation of cholangiocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24434010] +synonym: "activation of cholangiocyte proliferation" NARROW [GOC:TermGenie] +synonym: "activation of hepatoblast proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of cholangiocyte proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatoblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:1904054 ! regulation of cholangiocyte proliferation +relationship: positively_regulates GO:1990705 ! cholangiocyte proliferation + +[Term] +id: GO:1904057 +name: negative regulation of sensory perception of pain +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] +synonym: "down regulation of nociception" EXACT [GOC:TermGenie] +synonym: "down regulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "down regulation of sensory perception of pain" EXACT [GOC:TermGenie] +synonym: "down-regulation of nociception" EXACT [GOC:TermGenie] +synonym: "down-regulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "down-regulation of sensory perception of pain" EXACT [GOC:TermGenie] +synonym: "downregulation of nociception" EXACT [GOC:TermGenie] +synonym: "downregulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "downregulation of sensory perception of pain" EXACT [GOC:TermGenie] +synonym: "inhibition of nociception" NARROW [GOC:TermGenie] +synonym: "inhibition of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory perception of pain" NARROW [GOC:TermGenie] +synonym: "negative regulation of nociception" EXACT [GOC:TermGenie] +synonym: "negative regulation of perception of physiological pain" NARROW [GOC:TermGenie] +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:0051930 ! regulation of sensory perception of pain +relationship: negatively_regulates GO:0019233 ! sensory perception of pain + +[Term] +id: GO:1904058 +name: positive regulation of sensory perception of pain +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sensory perception of pain." [GO_REF:0000058, GOC:TermGenie, PMID:17167094] +synonym: "activation of nociception" NARROW [GOC:TermGenie] +synonym: "activation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "activation of sensory perception of pain" NARROW [GOC:TermGenie] +synonym: "positive regulation of nociception" EXACT [GOC:TermGenie] +synonym: "positive regulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "up regulation of nociception" EXACT [GOC:TermGenie] +synonym: "up regulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "up regulation of sensory perception of pain" EXACT [GOC:TermGenie] +synonym: "up-regulation of nociception" EXACT [GOC:TermGenie] +synonym: "up-regulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "up-regulation of sensory perception of pain" EXACT [GOC:TermGenie] +synonym: "upregulation of nociception" EXACT [GOC:TermGenie] +synonym: "upregulation of perception of physiological pain" NARROW [GOC:TermGenie] +synonym: "upregulation of sensory perception of pain" EXACT [GOC:TermGenie] +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:0051930 ! regulation of sensory perception of pain +relationship: positively_regulates GO:0019233 ! sensory perception of pain + +[Term] +id: GO:1904059 +name: regulation of locomotor rhythm +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] +synonym: "regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +is_a: GO:0042752 ! regulation of circadian rhythm +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0045475 ! locomotor rhythm + +[Term] +id: GO:1904060 +name: negative regulation of locomotor rhythm +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] +synonym: "down regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "down regulation of locomotor rhythm" EXACT [GOC:TermGenie] +synonym: "down-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "down-regulation of locomotor rhythm" EXACT [GOC:TermGenie] +synonym: "downregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "downregulation of locomotor rhythm" EXACT [GOC:TermGenie] +synonym: "inhibition of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "inhibition of locomotor rhythm" NARROW [GOC:TermGenie] +synonym: "negative regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +is_a: GO:0042754 ! negative regulation of circadian rhythm +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:1904059 ! regulation of locomotor rhythm +relationship: negatively_regulates GO:0045475 ! locomotor rhythm + +[Term] +id: GO:1904061 +name: positive regulation of locomotor rhythm +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of locomotor rhythm." [GO_REF:0000058, GOC:TermGenie, PMID:16310969] +synonym: "activation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "activation of locomotor rhythm" NARROW [GOC:TermGenie] +synonym: "positive regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "up regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "up regulation of locomotor rhythm" EXACT [GOC:TermGenie] +synonym: "up-regulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "up-regulation of locomotor rhythm" EXACT [GOC:TermGenie] +synonym: "upregulation of circadian locomotor activity rhythm" NARROW [GOC:TermGenie] +synonym: "upregulation of locomotor rhythm" EXACT [GOC:TermGenie] +is_a: GO:0042753 ! positive regulation of circadian rhythm +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:1904059 ! regulation of locomotor rhythm +relationship: positively_regulates GO:0045475 ! locomotor rhythm + +[Term] +id: GO:1904062 +name: regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +is_a: GO:0034765 ! regulation of ion transmembrane transport +relationship: regulates GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1904063 +name: negative regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +synonym: "down regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of cation transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: negatively_regulates GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1904064 +name: positive regulation of cation transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cation transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:15304482] +synonym: "activation of cation transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of cation transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of cation transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: positively_regulates GO:0098655 ! cation transmembrane transport + +[Term] +id: GO:1904065 +name: G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission +namespace: biological_process +def: "Any G protein-coupled acetylcholine receptor signaling pathway that is involved in positive regulation of acetylcholine secretion, neurotransmission." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22588719] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "acetylcholine receptor signalling, muscarinic pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "G-protein coupled acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in activation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in stimulation of acetylcholine secretion" NARROW [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in up regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in up-regulation of acetylcholine secretion" EXACT [GOC:TermGenie] +synonym: "muscarinic acetylcholine receptor signaling pathway involved in upregulation of acetylcholine secretion" EXACT [GOC:TermGenie] +is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway +relationship: part_of GO:0014057 ! positive regulation of acetylcholine secretion, neurotransmission + +[Term] +id: GO:1904066 +name: G protein-coupled receptor signaling pathway involved in dauer larval development +namespace: biological_process +def: "Any G protein-coupled receptor signaling pathway that is involved in dauer larval development." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789] +synonym: "G protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in dauer larval development" EXACT [GOC:TermGenie] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +relationship: part_of GO:0040024 ! dauer larval development + +[Term] +id: GO:1904067 +name: ascr#2 binding +namespace: molecular_function +def: "Binding to ascr#2." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:22665789] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:1904068 +name: G protein-coupled receptor signaling pathway involved in social behavior +namespace: biological_process +def: "Any G protein-coupled receptor signaling pathway that is involved in social behavior." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, pmid:22665789] +synonym: "G protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G protein coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signal transduction involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor signaling pathway involved in social behavior" EXACT [] +synonym: "G-protein coupled receptor signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G-protein coupled receptor signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "G-protein-coupled receptor protein signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "GPCR signaling pathway involved in social behaviour" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in cooperative behavior" RELATED [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in social behavior" EXACT [GOC:TermGenie] +synonym: "GPCR signalling pathway involved in social behaviour" EXACT [GOC:TermGenie] +is_a: GO:0007186 ! G protein-coupled receptor signaling pathway +relationship: part_of GO:0035176 ! social behavior + +[Term] +id: GO:1904069 +name: ascaroside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534] +synonym: "ascaroside metabolism" EXACT [GOC:TermGenie] +is_a: GO:0016137 ! glycoside metabolic process + +[Term] +id: GO:1904070 +name: ascaroside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ascaroside." [GO_REF:0000068, GOC:kmv, GOC:TermGenie, pmid:25775534] +synonym: "ascaroside anabolism" EXACT [GOC:TermGenie] +synonym: "ascaroside biosynthesis" EXACT [GOC:TermGenie] +synonym: "ascaroside formation" EXACT [GOC:TermGenie] +synonym: "ascaroside synthesis" EXACT [GOC:TermGenie] +is_a: GO:0016138 ! glycoside biosynthetic process +is_a: GO:1904069 ! ascaroside metabolic process + +[Term] +id: GO:1904071 +name: presynaptic active zone assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GO_REF:0000079, GOC:pr, GOC:TermGenie, PMID:10769383] +synonym: "pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "presynaptic active zone formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:1990709 ! presynaptic active zone organization +relationship: part_of GO:0099054 ! presynapse assembly + +[Term] +id: GO:1904072 +name: presynaptic active zone disassembly +namespace: biological_process +def: "The disaggregation of a presynaptic active zone into its constituent components." [GO_REF:0000079, GOC:pr, GOC:TermGenie, ISBN:9780387325606] +synonym: "pre-synaptic active zone component disassembly" NARROW [GOC:TermGenie] +synonym: "pre-synaptic active zone disassembly" EXACT [GOC:TermGenie] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:1990709 ! presynaptic active zone organization + +[Term] +id: GO:1904073 +name: regulation of trophectodermal cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] +synonym: "regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0001834 ! trophectodermal cell proliferation + +[Term] +id: GO:1904074 +name: negative regulation of trophectodermal cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] +synonym: "down regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of trophectoderm cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of trophectodermal cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:1904073 ! regulation of trophectodermal cell proliferation +relationship: negatively_regulates GO:0001834 ! trophectodermal cell proliferation + +[Term] +id: GO:1904075 +name: positive regulation of trophectodermal cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24508636] +synonym: "activation of trophectoderm cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of trophectodermal cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of trophectoderm cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of trophectodermal cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:1904073 ! regulation of trophectodermal cell proliferation +relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferation + +[Term] +id: GO:1904076 +name: regulation of estrogen biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] +synonym: "regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0006703 ! estrogen biosynthetic process + +[Term] +id: GO:1904077 +name: negative regulation of estrogen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] +synonym: "down regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "down regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "downregulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of estrogen anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of estrogen biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of estrogen biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of estrogen formation" NARROW [GOC:TermGenie] +synonym: "inhibition of estrogen synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of oestrogen biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of oestrogen biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:1904076 ! regulation of estrogen biosynthetic process +relationship: negatively_regulates GO:0006703 ! estrogen biosynthetic process + +[Term] +id: GO:1904078 +name: positive regulation of estrogen biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of estrogen biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24530842] +synonym: "activation of estrogen anabolism" NARROW [GOC:TermGenie] +synonym: "activation of estrogen biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of estrogen biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of estrogen formation" NARROW [GOC:TermGenie] +synonym: "activation of estrogen synthesis" NARROW [GOC:TermGenie] +synonym: "activation of oestrogen biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of oestrogen biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "up regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of estrogen anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of estrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of estrogen biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of estrogen formation" EXACT [GOC:TermGenie] +synonym: "upregulation of estrogen synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of oestrogen biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of oestrogen biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:1904076 ! regulation of estrogen biosynthetic process +relationship: positively_regulates GO:0006703 ! estrogen biosynthetic process + +[Term] +id: GO:1904079 +name: obsolete negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process +namespace: biological_process +def: "OBSOLETE. Any negative regulation of transcription from RNA polymerase II promoter that is involved in negative regulation of neuron apoptotic process." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:20150917] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "negative regulation of global transcription from Pol II promoter involved in neuron survival" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of neuron apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from Pol II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in down-regulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in downregulation of neuron apoptosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in inhibition of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of neuron apoptotic process" EXACT [] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in negative regulation of programmed cell death, neurons" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in neuron survival" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in down-regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in downregulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in inhibition of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptosis" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of neuron apoptotic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in negative regulation of programmed cell death, neurons" RELATED [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in neuron survival" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0000122 +consider: GO:0043524 + +[Term] +id: GO:1904080 +name: obsolete positive regulation of transcription from RNA polymerase II promoter involved in neuron fate specification +namespace: biological_process +def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron fate specification." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:11959845] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron fate specification" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron fate specification" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0045944 +consider: GO:0048665 + +[Term] +id: GO:1904081 +name: positive regulation of transcription from RNA polymerase II promoter involved in neuron differentiation +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in neuron differentiation." [GO_REF:0000060, GOC:kmv, GOC:TermGenie, PMID:24353061] +synonym: "activation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in neuron differentiation" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0030182 ! neuron differentiation + +[Term] +id: GO:1904082 +name: pyrimidine nucleobase transmembrane transport +namespace: biological_process +def: "The process in which pyrimidine is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] +is_a: GO:0015855 ! pyrimidine nucleobase transport +is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport + +[Term] +id: GO:1904083 +name: obsolete regulation of epiboly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of epiboly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1904084 +name: obsolete negative regulation of epiboly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of epiboly" EXACT [GOC:TermGenie] +synonym: "down-regulation of epiboly" EXACT [GOC:TermGenie] +synonym: "downregulation of epiboly" EXACT [GOC:TermGenie] +synonym: "inhibition of epiboly" NARROW [GOC:TermGenie] +synonym: "negative regulation of epiboly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1904085 +name: obsolete positive regulation of epiboly +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of epiboly." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of epiboly" NARROW [GOC:TermGenie] +synonym: "positive regulation of epiboly" EXACT [] +synonym: "up regulation of epiboly" EXACT [GOC:TermGenie] +synonym: "up-regulation of epiboly" EXACT [GOC:TermGenie] +synonym: "upregulation of epiboly" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904086 +name: regulation of epiboly involved in gastrulation with mouth forming second +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second + +[Term] +id: GO:1904087 +name: negative regulation of epiboly involved in gastrulation with mouth forming second +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +synonym: "down-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +synonym: "downregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +synonym: "inhibition of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie] +is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second + +[Term] +id: GO:1904088 +name: positive regulation of epiboly involved in gastrulation with mouth forming second +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second." [GO_REF:0000058, GOC:TermGenie, PMID:24892953] +synonym: "activation of epiboly involved in gastrulation with mouth forming second" NARROW [GOC:TermGenie] +synonym: "up regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +synonym: "up-regulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +synonym: "upregulation of epiboly involved in gastrulation with mouth forming second" EXACT [GOC:TermGenie] +is_a: GO:1904086 ! regulation of epiboly involved in gastrulation with mouth forming second +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0055113 ! epiboly involved in gastrulation with mouth forming second + +[Term] +id: GO:1904089 +name: negative regulation of neuron apoptotic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of neuron apoptotic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:20150917] +synonym: "negative regulation of neuron apoptosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of programmed cell death, neurons by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0043524 ! negative regulation of neuron apoptotic process + +[Term] +id: GO:1904090 +name: peptidase inhibitor complex +namespace: cellular_component +def: "A protein complex which is capable of peptidase inhibitor activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624] +comment: An example of this is Cystatin-A in human (UniProt symbol P01040) in PMID:20860624 (inferred from physical interaction). +synonym: "Cathepsin-B - cystatin-A complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1904091 +name: peptidyl carrier protein activity +namespace: molecular_function +def: "Binding an amino-acid derived peptidyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the peptidyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. Peptidyl carrier protein (PCP) is involved in nonribosomal peptide biosynthetic process." [GO_REF:0000061, GOC:pr, GOC:TermGenie, GOC:vw, PMID:17502372] +comment: Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process. +synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie] +synonym: "Oligopeptid binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] +synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] +synonym: "oligopeptide binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptide binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] +synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in non-ribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in non-ribosomal peptide formation" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in non-ribosomal peptide synthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide anabolism" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide formation" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide synthesis" EXACT [GOC:TermGenie] +synonym: "oligopeptides binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthesis" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in non-ribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in non-ribosomal peptide formation" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in non-ribosomal peptide synthesis" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide anabolism" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide biosynthesis" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide biosynthetic process" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide formation" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide synthesis" RELATED [GOC:TermGenie] +synonym: "oligopeptido binding involved in nonribosomal peptide synthetase" RELATED [GOC:TermGenie] +synonym: "PCP" RELATED [] +synonym: "peptidyl binding involved in nonribosomal peptide biosynthesis" EXACT [GOC:pr] +synonym: "peptidyl binding involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] +synonym: "peptidyl carrier protein" RELATED [GOC:pr] +synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis" EXACT [] +synonym: "peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process" EXACT [GOC:pr] +is_a: GO:0140414 ! phosphopantetheine-dependent carrier activity + +[Term] +id: GO:1904092 +name: regulation of autophagic cell death +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] +synonym: "regulation of autophagic death" BROAD [GOC:TermGenie] +synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie] +synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0048102 ! autophagic cell death + +[Term] +id: GO:1904093 +name: negative regulation of autophagic cell death +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] +synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie] +synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] +synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:1904092 ! regulation of autophagic cell death +relationship: negatively_regulates GO:0048102 ! autophagic cell death + +[Term] +id: GO:1904094 +name: positive regulation of autophagic cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] +synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie] +synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] +synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie] +synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie] +synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:1904092 ! regulation of autophagic cell death +relationship: positively_regulates GO:0048102 ! autophagic cell death + +[Term] +id: GO:1904095 +name: negative regulation of endosperm development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosperm development." [GO_REF:0000058, GOC:TermGenie, PMID:25194028] +synonym: "down regulation of endosperm development" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosperm development" EXACT [GOC:TermGenie] +synonym: "downregulation of endosperm development" EXACT [GOC:TermGenie] +synonym: "inhibition of endosperm development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000014 ! regulation of endosperm development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0009960 ! endosperm development + +[Term] +id: GO:1904096 +name: protein tyrosine phosphatase complex +namespace: cellular_component +def: "A protein complex which is capable of protein tyrosine phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:22389722] +comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction). +is_a: GO:1903293 ! phosphatase complex + +[Term] +id: GO:1904097 +name: acid phosphatase complex +namespace: cellular_component +def: "A protein complex which is capable of acid phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:8132635] +comment: An example of this is ACPP in human (UniProt symbol P15309) in PMID:22389722 (inferred from physical interaction). +is_a: GO:1903293 ! phosphatase complex + +[Term] +id: GO:1904098 +name: regulation of protein O-linked glycosylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] +synonym: "regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +is_a: GO:0060049 ! regulation of protein glycosylation +relationship: regulates GO:0006493 ! protein O-linked glycosylation + +[Term] +id: GO:1904099 +name: negative regulation of protein O-linked glycosylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] +synonym: "down regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein O-linked glycosylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +is_a: GO:0060051 ! negative regulation of protein glycosylation +is_a: GO:1904098 ! regulation of protein O-linked glycosylation +relationship: negatively_regulates GO:0006493 ! protein O-linked glycosylation + +[Term] +id: GO:1904100 +name: positive regulation of protein O-linked glycosylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation." [GO_REF:0000058, GOC:TermGenie, PMID:24509081] +synonym: "activation of protein amino acid O-linked glycosylation" NARROW [GOC:TermGenie] +synonym: "activation of protein O-linked glycosylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein amino acid O-linked glycosylation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein O-linked glycosylation" EXACT [GOC:TermGenie] +is_a: GO:0060050 ! positive regulation of protein glycosylation +is_a: GO:1904098 ! regulation of protein O-linked glycosylation +relationship: positively_regulates GO:0006493 ! protein O-linked glycosylation + +[Term] +id: GO:1904101 +name: response to acadesine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904102 +name: cellular response to acadesine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acadesine stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:20802119] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904101 ! response to acadesine + +[Term] +id: GO:1904103 +name: regulation of convergent extension involved in gastrulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:1904104 +name: negative regulation of convergent extension involved in gastrulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:1904105 +name: positive regulation of convergent extension involved in gastrulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in gastrulation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "activation of convergent extension involved in gastrulation" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in gastrulation" EXACT [GOC:TermGenie] +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0060027 ! convergent extension involved in gastrulation + +[Term] +id: GO:1904106 +name: protein localization to microvillus +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a microvillus." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] +synonym: "protein localisation in microvillus" EXACT [GOC:TermGenie] +synonym: "protein localisation to microvillus" EXACT [GOC:TermGenie] +synonym: "protein localization in microvillus" EXACT [GOC:TermGenie] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:1904107 +name: protein localization to microvillus membrane +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a microvillus membrane." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] +synonym: "protein localisation in microvillus membrane" EXACT [GOC:TermGenie] +synonym: "protein localisation to microvillus membrane" EXACT [GOC:TermGenie] +synonym: "protein localization in microvillus membrane" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:1904106 ! protein localization to microvillus +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1904108 +name: protein localization to ciliary inversin compartment +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:25335890] +synonym: "protein localisation in ciliary inversin compartment" EXACT [GOC:TermGenie] +synonym: "protein localisation to ciliary inversin compartment" EXACT [GOC:TermGenie] +synonym: "protein localization in ciliary inversin compartment" EXACT [GOC:TermGenie] +is_a: GO:0061512 ! protein localization to cilium + +[Term] +id: GO:1904109 +name: positive regulation of cholesterol import +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cholesterol import." [GO_REF:0000058, GOC:TermGenie, PMID:16772292] +synonym: "activation of cholesterol import" NARROW [GOC:TermGenie] +synonym: "activation of cholesterol uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of cholesterol uptake" EXACT [GOC:TermGenie] +synonym: "up regulation of cholesterol import" EXACT [GOC:TermGenie] +synonym: "up regulation of cholesterol uptake" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholesterol import" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholesterol uptake" EXACT [GOC:TermGenie] +synonym: "upregulation of cholesterol import" EXACT [GOC:TermGenie] +synonym: "upregulation of cholesterol uptake" EXACT [GOC:TermGenie] +is_a: GO:0032376 ! positive regulation of cholesterol transport +is_a: GO:0060620 ! regulation of cholesterol import +is_a: GO:2000911 ! positive regulation of sterol import +relationship: positively_regulates GO:0070508 ! cholesterol import + +[Term] +id: GO:1904110 +name: obsolete regulation of plus-end directed microfilament motor activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:1904111 +name: obsolete negative regulation of plus-end directed microfilament motor activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] +comment: This term was obsoleted because it represents a molecular function. +synonym: "down regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "down regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "downregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +synonym: "inhibition of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "inhibition of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0140661 + +[Term] +id: GO:1904112 +name: obsolete positive regulation of plus-end directed microfilament motor activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of plus-end directed microfilament motor activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:25717181] +comment: This term was obsoleted because it represents a molecular function. +synonym: "activation of barbed-end directed actin-filament motor activity" NARROW [GOC:TermGenie] +synonym: "activation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "activation of plus-end directed actin-filament motor activity" NARROW [GOC:TermGenie] +synonym: "activation of plus-end directed microfilament motor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "up regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of barbed-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of plus-end directed actin filament motor activity" RELATED [GOC:TermGenie] +synonym: "upregulation of plus-end directed actin-filament motor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of plus-end directed microfilament motor activity" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:1904113 +name: negative regulation of muscle filament sliding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181] +synonym: "down regulation of muscle filament sliding" EXACT [GOC:TermGenie] +synonym: "down-regulation of muscle filament sliding" EXACT [GOC:TermGenie] +synonym: "downregulation of muscle filament sliding" EXACT [GOC:TermGenie] +synonym: "inhibition of muscle filament sliding" NARROW [GOC:TermGenie] +is_a: GO:0032971 ! regulation of muscle filament sliding +is_a: GO:0045932 ! negative regulation of muscle contraction +is_a: GO:0051271 ! negative regulation of cellular component movement +relationship: negatively_regulates GO:0030049 ! muscle filament sliding + +[Term] +id: GO:1904114 +name: positive regulation of muscle filament sliding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of muscle filament sliding." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:25717181] +synonym: "activation of muscle filament sliding" NARROW [GOC:TermGenie] +synonym: "up regulation of muscle filament sliding" EXACT [GOC:TermGenie] +synonym: "up-regulation of muscle filament sliding" EXACT [GOC:TermGenie] +synonym: "upregulation of muscle filament sliding" EXACT [GOC:TermGenie] +is_a: GO:0032971 ! regulation of muscle filament sliding +is_a: GO:1903116 ! positive regulation of actin filament-based movement +relationship: positively_regulates GO:0030049 ! muscle filament sliding + +[Term] +id: GO:1904115 +name: axon cytoplasm +namespace: cellular_component +def: "Any cytoplasm that is part of a axon." [GO_REF:0000064, GOC:TermGenie, PMID:18667152] +synonym: "axoplasm" EXACT [] +is_a: GO:0120111 ! neuron projection cytoplasm +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:1904116 +name: response to vasopressin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1904117 +name: cellular response to vasopressin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vasopressin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22811487] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1904116 ! response to vasopressin + +[Term] +id: GO:1904118 +name: regulation of otic vesicle morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0071600 ! otic vesicle morphogenesis + +[Term] +id: GO:1904119 +name: negative regulation of otic vesicle morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] +synonym: "down regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of otic vesicle morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0110111 ! negative regulation of animal organ morphogenesis +is_a: GO:1904118 ! regulation of otic vesicle morphogenesis +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0071600 ! otic vesicle morphogenesis + +[Term] +id: GO:1904120 +name: positive regulation of otic vesicle morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of otic vesicle morphogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:25677106] +synonym: "activation of otic vesicle morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of otic vesicle morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0110110 ! positive regulation of animal organ morphogenesis +is_a: GO:1904118 ! regulation of otic vesicle morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0071600 ! otic vesicle morphogenesis + +[Term] +id: GO:1904121 +name: phosphatidylethanolamine transfer activity +namespace: molecular_function +def: "Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle." [GO_REF:0000066, GOC:TermGenie, PMID:8606365] +synonym: "intermembrane phosphatidylethanolamine transfer activity" NARROW [] +synonym: "phosphatidylethanolamine carrier activity" EXACT [] +synonym: "phosphatidylethanolamine transporter activity" BROAD [] +is_a: GO:0120014 ! phospholipid transfer activity + +[Term] +id: GO:1904122 +name: positive regulation of fatty acid beta-oxidation by octopamine signaling pathway +namespace: biological_process +def: "An octopamine signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942] +synonym: "activation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie] +synonym: "stimulation of fatty acid beta-oxidation by octopamine signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of fatty acid beta-oxidation by octopamine signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation +is_a: GO:0071927 ! octopamine signaling pathway + +[Term] +id: GO:1904123 +name: positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway +namespace: biological_process +def: "A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation." [GO_REF:0000063, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24120942] +synonym: "activation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "stimulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "up regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of fatty acid beta-oxidation by serotonin receptor signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:0007210 ! serotonin receptor signaling pathway +is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation + +[Term] +id: GO:1904124 +name: microglial cell migration +namespace: biological_process +def: "The orderly movement of a microglial cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +is_a: GO:0008347 ! glial cell migration +is_a: GO:1905517 ! macrophage migration + +[Term] +id: GO:1904125 +name: convergent extension involved in rhombomere morphogenesis +namespace: biological_process +def: "Any convergent extension that is involved in rhombomere morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:0060027 ! convergent extension involved in gastrulation +is_a: GO:0060029 ! convergent extension involved in organogenesis +relationship: part_of GO:0021593 ! rhombomere morphogenesis + +[Term] +id: GO:1904126 +name: convergent extension involved in notochord morphogenesis +namespace: biological_process +def: "Any convergent extension that is involved in notochord morphogenesis." [GO_REF:0000060, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:0060027 ! convergent extension involved in gastrulation +is_a: GO:0060029 ! convergent extension involved in organogenesis +relationship: part_of GO:0048570 ! notochord morphogenesis + +[Term] +id: GO:1904127 +name: regulation of convergent extension involved in somitogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:1901232 ! regulation of convergent extension involved in axis elongation +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +relationship: regulates GO:0090246 ! convergent extension involved in somitogenesis + +[Term] +id: GO:1904128 +name: negative regulation of convergent extension involved in somitogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] +is_a: GO:1901233 ! negative regulation of convergent extension involved in axis elongation +is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation +is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis +relationship: negatively_regulates GO:0090246 ! convergent extension involved in somitogenesis + +[Term] +id: GO:1904129 +name: positive regulation of convergent extension involved in somitogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "activation of convergent extension involved in somitogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in somitogenesis" EXACT [GOC:TermGenie] +is_a: GO:1901234 ! positive regulation of convergent extension involved in axis elongation +is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation +is_a: GO:1904127 ! regulation of convergent extension involved in somitogenesis +relationship: positively_regulates GO:0090246 ! convergent extension involved in somitogenesis + +[Term] +id: GO:1904130 +name: regulation of convergent extension involved in neural plate elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +relationship: regulates GO:0022007 ! convergent extension involved in neural plate elongation + +[Term] +id: GO:1904131 +name: negative regulation of convergent extension involved in neural plate elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] +is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation +is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation +relationship: negatively_regulates GO:0022007 ! convergent extension involved in neural plate elongation + +[Term] +id: GO:1904132 +name: positive regulation of convergent extension involved in neural plate elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in neural plate elongation." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "activation of convergent extension involved in neural plate elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in neural plate elongation" EXACT [GOC:TermGenie] +is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation +is_a: GO:1904130 ! regulation of convergent extension involved in neural plate elongation +relationship: positively_regulates GO:0022007 ! convergent extension involved in neural plate elongation + +[Term] +id: GO:1904133 +name: regulation of convergent extension involved in rhombomere morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +relationship: regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis + +[Term] +id: GO:1904134 +name: negative regulation of convergent extension involved in rhombomere morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation +is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis +relationship: negatively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis + +[Term] +id: GO:1904135 +name: positive regulation of convergent extension involved in rhombomere morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "activation of convergent extension involved in rhombomere morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in rhombomere morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation +is_a: GO:1904133 ! regulation of convergent extension involved in rhombomere morphogenesis +relationship: positively_regulates GO:1904125 ! convergent extension involved in rhombomere morphogenesis + +[Term] +id: GO:1904136 +name: regulation of convergent extension involved in notochord morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +is_a: GO:1904103 ! regulation of convergent extension involved in gastrulation +relationship: regulates GO:1904126 ! convergent extension involved in notochord morphogenesis + +[Term] +id: GO:1904137 +name: negative regulation of convergent extension involved in notochord morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "down regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:1904104 ! negative regulation of convergent extension involved in gastrulation +is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis +relationship: negatively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis + +[Term] +id: GO:1904138 +name: positive regulation of convergent extension involved in notochord morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:24892953] +synonym: "activation of convergent extension involved in notochord morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of convergent extension involved in notochord morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:1904105 ! positive regulation of convergent extension involved in gastrulation +is_a: GO:1904136 ! regulation of convergent extension involved in notochord morphogenesis +relationship: positively_regulates GO:1904126 ! convergent extension involved in notochord morphogenesis + +[Term] +id: GO:1904139 +name: regulation of microglial cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +is_a: GO:1903975 ! regulation of glial cell migration +is_a: GO:1905521 ! regulation of macrophage migration +relationship: regulates GO:1904124 ! microglial cell migration + +[Term] +id: GO:1904140 +name: negative regulation of microglial cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of microglial cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of microglial cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of microglial cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of microglial cell migration" NARROW [GOC:TermGenie] +is_a: GO:1903976 ! negative regulation of glial cell migration +is_a: GO:1904139 ! regulation of microglial cell migration +is_a: GO:1905522 ! negative regulation of macrophage migration +relationship: negatively_regulates GO:1904124 ! microglial cell migration + +[Term] +id: GO:1904141 +name: positive regulation of microglial cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microglial cell migration." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of microglial cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of microglial cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of microglial cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of microglial cell migration" EXACT [GOC:TermGenie] +is_a: GO:1903977 ! positive regulation of glial cell migration +is_a: GO:1904139 ! regulation of microglial cell migration +is_a: GO:1905523 ! positive regulation of macrophage migration +relationship: positively_regulates GO:1904124 ! microglial cell migration + +[Term] +id: GO:1904142 +name: negative regulation of carotenoid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] +synonym: "down regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of carotenoid anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of carotenoid biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of carotenoid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of carotenoid formation" NARROW [GOC:TermGenie] +synonym: "inhibition of carotenoid synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051055 ! negative regulation of lipid biosynthetic process +relationship: negatively_regulates GO:0016117 ! carotenoid biosynthetic process + +[Term] +id: GO:1904143 +name: positive regulation of carotenoid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of carotenoid biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:25675505] +synonym: "activation of carotenoid anabolism" NARROW [GOC:TermGenie] +synonym: "activation of carotenoid biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of carotenoid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of carotenoid formation" NARROW [GOC:TermGenie] +synonym: "activation of carotenoid synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of carotenoid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of carotenoid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of carotenoid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of carotenoid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of carotenoid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of carotenoid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +relationship: positively_regulates GO:0016117 ! carotenoid biosynthetic process + +[Term] +id: GO:1904144 +name: phosphatidylinositol phosphate phosphatase complex +namespace: cellular_component +def: "A protein complex which is capable of phosphatidylinositol phosphate phosphatase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12525165] +comment: An example of this is ACPP in human (P15309) in PMID:12525165 (inferred from physical interaction). +synonym: "prostatic acid phosphatase complex" NARROW [] +is_a: GO:1903293 ! phosphatase complex + +[Term] +id: GO:1904145 +name: negative regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] +synonym: "down regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +is_a: GO:1900194 ! negative regulation of oocyte maturation +is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation +relationship: negatively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation + +[Term] +id: GO:1904146 +name: positive regulation of meiotic cell cycle process involved in oocyte maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation." [GO_REF:0000058, GOC:TermGenie, PMID:22674394] +synonym: "activation of meiotic cell cycle process involved in oocyte maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic cell cycle process involved in oocyte maturation" EXACT [GOC:TermGenie] +is_a: GO:0051446 ! positive regulation of meiotic cell cycle +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1903538 ! regulation of meiotic cell cycle process involved in oocyte maturation +relationship: positively_regulates GO:1903537 ! meiotic cell cycle process involved in oocyte maturation + +[Term] +id: GO:1904147 +name: response to nonylphenol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1904148 +name: cellular response to nonylphenol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nonylphenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19260726] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904147 ! response to nonylphenol + +[Term] +id: GO:1904149 +name: regulation of microglial cell mediated cytotoxicity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity +is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity +relationship: regulates GO:0090634 ! microglial cell mediated cytotoxicity + +[Term] +id: GO:1904150 +name: negative regulation of microglial cell mediated cytotoxicity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "down regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +synonym: "down-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +synonym: "downregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +synonym: "inhibition of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] +is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity +is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity +is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity +relationship: negatively_regulates GO:0090634 ! microglial cell mediated cytotoxicity + +[Term] +id: GO:1904151 +name: positive regulation of microglial cell mediated cytotoxicity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:19100238] +synonym: "activation of microglial cell mediated cytotoxicity" NARROW [GOC:TermGenie] +synonym: "up regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +synonym: "up-regulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +synonym: "upregulation of microglial cell mediated cytotoxicity" EXACT [GOC:TermGenie] +is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity +is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity +is_a: GO:1904149 ! regulation of microglial cell mediated cytotoxicity +relationship: positively_regulates GO:0090634 ! microglial cell mediated cytotoxicity + +[Term] +id: GO:1904152 +name: regulation of retrograde protein transport, ER to cytosol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] +synonym: "regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "regulation of protein retrotranslocation from ER" EXACT [GOC:bf] +synonym: "regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +is_a: GO:0070861 ! regulation of protein exit from endoplasmic reticulum +relationship: regulates GO:0030970 ! retrograde protein transport, ER to cytosol + +[Term] +id: GO:1904153 +name: negative regulation of retrograde protein transport, ER to cytosol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] +synonym: "down regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "down regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "down regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "downregulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "inhibition of protein dislocation from ER" NARROW [GOC:TermGenie] +synonym: "inhibition of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie] +synonym: "inhibition of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein retrotranslocation from ER" EXACT [GOC:bf] +synonym: "negative regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +is_a: GO:0070862 ! negative regulation of protein exit from endoplasmic reticulum +is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol +relationship: negatively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol + +[Term] +id: GO:1904154 +name: positive regulation of retrograde protein transport, ER to cytosol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde protein transport, ER to cytosol." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18555783] +synonym: "activation of protein dislocation from ER" NARROW [GOC:TermGenie] +synonym: "activation of retrograde protein transport, endoplasmic reticulum to cytosol" NARROW [GOC:TermGenie] +synonym: "activation of retrograde protein transport, ER to cytosol" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein retrotranslocation from ER" EXACT [GOC:bf] +synonym: "positive regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "up regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "up regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "up regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein retrotranslocation from ER" EXACT [GOC:bf] +synonym: "up-regulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "upregulation of protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde protein transport, ER to cytosol" EXACT [GOC:TermGenie] +is_a: GO:0070863 ! positive regulation of protein exit from endoplasmic reticulum +is_a: GO:1904152 ! regulation of retrograde protein transport, ER to cytosol +relationship: positively_regulates GO:0030970 ! retrograde protein transport, ER to cytosol + +[Term] +id: GO:1904155 +name: DN2 thymocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN2 thymocyte. A DN2 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] +is_a: GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:1904156 +name: DN3 thymocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN3 thymocyte. A DN3 thymocyte is a CD4-,CD8- thymocyte that is also CD44+,CD25+." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] +is_a: GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:1904157 +name: DN4 thymocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a DN4 thymocyte. A DN4 thymocyte is a CD4-,CD8- thymocyte that is also CD44-,CD25-." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:25398325] +is_a: GO:0033077 ! T cell differentiation in thymus + +[Term] +id: GO:1904158 +name: axonemal central apparatus assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus." [GO_REF:0000079, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:9295136] +synonym: "axonemal central apparatus formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0035082 ! axoneme assembly + +[Term] +id: GO:1904159 +name: megasporocyte differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a megasporocyte." [GO_REF:0000086, GOC:tair_curators, GOC:TermGenie] +comment: The process aimed at the progression of a megasporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A megasporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) megaspores; also called megaspore mother cell. +synonym: "megaspore mother cell differentiation" EXACT [GOC:tair_curators] +is_a: GO:0048533 ! sporocyte differentiation + +[Term] +id: GO:1904160 +name: protein localization to chloroplast starch grain +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a chloroplast starch grain." [GO_REF:0000087, GOC:TermGenie, PMID:25710501] +synonym: "protein localisation in chloroplast starch grain" EXACT [GOC:TermGenie] +synonym: "protein localisation to chloroplast starch grain" EXACT [GOC:TermGenie] +synonym: "protein localization in chloroplast starch grain" EXACT [GOC:TermGenie] +is_a: GO:0072598 ! protein localization to chloroplast + +[Term] +id: GO:1904161 +name: DNA synthesis involved in UV-damage excision repair +namespace: biological_process +def: "Any DNA synthesis that is involved in UV-damage excision repair." [GO_REF:0000060, GOC:TermGenie, PMID:10704216] +synonym: "DNA synthesis during UV-damage excision repair" RELATED [GOC:TermGenie] +synonym: "DNA synthesis during UV-damaged DNA endonuclease-dependent excision repair" RELATED [GOC:TermGenie] +synonym: "DNA synthesis during UVDE-dependent excision repair" RELATED [GOC:TermGenie] +synonym: "DNA synthesis during UVER" RELATED [GOC:TermGenie] +synonym: "DNA synthesis involved in AER" RELATED [GOC:mah, PMID:10704216] +synonym: "DNA synthesis involved in alternative excision repair" RELATED [GOC:mah, PMID:10704216] +synonym: "DNA synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in UVER" EXACT [GOC:TermGenie] +synonym: "mitotic DNA repair synthesis involved in UV-damage excision repair" NARROW [GOC:TermGenie] +synonym: "mitotic DNA repair synthesis involved in UV-damaged DNA endonuclease-dependent excision repair" NARROW [GOC:TermGenie] +synonym: "mitotic DNA repair synthesis involved in UVDE-dependent excision repair" NARROW [GOC:TermGenie] +synonym: "mitotic DNA repair synthesis involved in UVER" NARROW [GOC:TermGenie] +is_a: GO:0000731 ! DNA synthesis involved in DNA repair +relationship: part_of GO:0070914 ! UV-damage excision repair + +[Term] +id: GO:1904162 +name: obsolete 5'-3' exodeoxyribonuclease activity involved in UV-damage excision repair +namespace: molecular_function +def: "OBSOLETE. Any 5'-3' exodeoxyribonuclease activity that is involved in UV-damage excision repair." [GO_REF:0000061, GOC:TermGenie, PMID:10704216] +comment: The reason for obsoletion is that this term represents a biological process within a molecular function. +synonym: "5'-3' exodeoxyribonuclease activity involved in AER" RELATED [GOC:mah] +synonym: "5'-3' exodeoxyribonuclease activity involved in alternative excision repair" RELATED [GOC:mah] +synonym: "5'-3' exodeoxyribonuclease activity involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:TermGenie] +synonym: "5'-3' exodeoxyribonuclease activity involved in UVDE-dependent excision repair" EXACT [GOC:TermGenie] +synonym: "5'-3' exodeoxyribonuclease activity involved in UVER" EXACT [GOC:TermGenie] +is_obsolete: true +consider: GO:0070914 + +[Term] +id: GO:1904163 +name: obsolete regulation of triglyceride homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904164 +name: obsolete negative regulation of triglyceride homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "down regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +synonym: "down-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "down-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +synonym: "downregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "downregulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +synonym: "inhibition of triacylglycerol homeostasis" NARROW [GOC:TermGenie] +synonym: "inhibition of triglyceride homeostasis" NARROW [GOC:TermGenie] +synonym: "negative regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904165 +name: obsolete positive regulation of triglyceride homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of triglyceride homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of triacylglycerol homeostasis" NARROW [GOC:TermGenie] +synonym: "activation of triglyceride homeostasis" NARROW [GOC:TermGenie] +synonym: "positive regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "up regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "up regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +synonym: "up-regulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "up-regulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +synonym: "upregulation of triacylglycerol homeostasis" EXACT [GOC:TermGenie] +synonym: "upregulation of triglyceride homeostasis" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904166 +name: obsolete negative regulation of cholesterol homeostasis +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol homeostasis." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:22541436] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of cholesterol homeostasis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cholesterol homeostasis" EXACT [GOC:TermGenie] +synonym: "downregulation of cholesterol homeostasis" EXACT [GOC:TermGenie] +synonym: "inhibition of cholesterol homeostasis" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904170 +name: regulation of bleb assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] +synonym: "regulation of cell blebbing" EXACT [GOC:TermGenie] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0032060 ! bleb assembly + +[Term] +id: GO:1904171 +name: negative regulation of bleb assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] +synonym: "down regulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "down-regulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "downregulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "inhibition of bleb assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of cell blebbing" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell blebbing" EXACT [GOC:TermGenie] +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +is_a: GO:1904170 ! regulation of bleb assembly +relationship: negatively_regulates GO:0032060 ! bleb assembly + +[Term] +id: GO:1904172 +name: positive regulation of bleb assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bleb assembly." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:25651887] +synonym: "activation of bleb assembly" NARROW [GOC:TermGenie] +synonym: "activation of cell blebbing" NARROW [GOC:TermGenie] +synonym: "positive regulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "up regulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "up-regulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell blebbing" EXACT [GOC:TermGenie] +synonym: "upregulation of bleb assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of cell blebbing" EXACT [GOC:TermGenie] +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:1904170 ! regulation of bleb assembly +relationship: positively_regulates GO:0032060 ! bleb assembly + +[Term] +id: GO:1904173 +name: regulation of histone demethylase activity (H3-K4 specific) +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] +is_a: GO:0031056 ! regulation of histone modification +is_a: GO:0050790 ! regulation of catalytic activity + +[Term] +id: GO:1904174 +name: negative regulation of histone demethylase activity (H3-K4 specific) +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] +synonym: "down regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +synonym: "downregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +synonym: "inhibition of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie] +is_a: GO:0031057 ! negative regulation of histone modification +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific) + +[Term] +id: GO:1904175 +name: positive regulation of histone demethylase activity (H3-K4 specific) +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific)." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:24843136] +synonym: "activation of histone demethylase activity (H3-K4 specific)" NARROW [GOC:TermGenie] +synonym: "up regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +synonym: "upregulation of histone demethylase activity (H3-K4 specific)" EXACT [GOC:TermGenie] +is_a: GO:0031058 ! positive regulation of histone modification +is_a: GO:0043085 ! positive regulation of catalytic activity +is_a: GO:1904173 ! regulation of histone demethylase activity (H3-K4 specific) + +[Term] +id: GO:1904176 +name: carbon phosphorus lyase complex +namespace: cellular_component +def: "A protein complex which is capable of carbon phosphorus lyase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17993513, PMID:21705661, PMID:22089136, PMID:23830682] +comment: An example of this is PhnJ in E. coli (P16688) in PMID:22089136 (inferred from direct assay). +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1904177 +name: regulation of adipose tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] +synonym: "regulation of adipogenesis" RELATED [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0060612 ! adipose tissue development + +[Term] +id: GO:1904178 +name: negative regulation of adipose tissue development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] +synonym: "down regulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of adipose tissue development" EXACT [GOC:TermGenie] +synonym: "down-regulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of adipose tissue development" EXACT [GOC:TermGenie] +synonym: "downregulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of adipose tissue development" EXACT [GOC:TermGenie] +synonym: "inhibition of adipogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of adipose tissue development" NARROW [GOC:TermGenie] +synonym: "negative regulation of adipogenesis" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904177 ! regulation of adipose tissue development +relationship: negatively_regulates GO:0060612 ! adipose tissue development + +[Term] +id: GO:1904179 +name: positive regulation of adipose tissue development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adipose tissue development." [GO_REF:0000058, GOC:TermGenie, PMID:23081848] +synonym: "activation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "activation of adipose tissue development" NARROW [GOC:TermGenie] +synonym: "positive regulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of adipose tissue development" EXACT [GOC:TermGenie] +synonym: "up-regulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of adipose tissue development" EXACT [GOC:TermGenie] +synonym: "upregulation of adipogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of adipose tissue development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904177 ! regulation of adipose tissue development +relationship: positively_regulates GO:0060612 ! adipose tissue development + +[Term] +id: GO:1904180 +name: negative regulation of membrane depolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] +synonym: "down regulation of membrane depolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane depolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane depolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane depolarization" NARROW [GOC:TermGenie] +is_a: GO:0003254 ! regulation of membrane depolarization +is_a: GO:0048519 ! negative regulation of biological process +relationship: negatively_regulates GO:0051899 ! membrane depolarization + +[Term] +id: GO:1904181 +name: positive regulation of membrane depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] +synonym: "activation of membrane depolarization" NARROW [GOC:TermGenie] +synonym: "up regulation of membrane depolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane depolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane depolarization" EXACT [GOC:TermGenie] +is_a: GO:0003254 ! regulation of membrane depolarization +is_a: GO:0048518 ! positive regulation of biological process +relationship: positively_regulates GO:0051899 ! membrane depolarization + +[Term] +id: GO:1904182 +name: regulation of pyruvate dehydrogenase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] +synonym: "regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1904183 +name: negative regulation of pyruvate dehydrogenase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] +synonym: "down regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity + +[Term] +id: GO:1904184 +name: positive regulation of pyruvate dehydrogenase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pyruvate dehydrogenase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, PMID:25525879] +synonym: "activation of pyruvate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of pyruvic acid dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of pyruvic dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pyruvate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pyruvic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of pyruvic dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1904182 ! regulation of pyruvate dehydrogenase activity + +[Term] +id: GO:1904185 +name: equatorial microtubule organizing center assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO_REF:0000079, GOC:TermGenie, PMID:15004232] +synonym: "EMTOC assembly" EXACT [GOC:TermGenie] +synonym: "EMTOC formation" EXACT [GOC:TermGenie] +synonym: "equatorial microtubule organising centre assembly" EXACT [GOC:TermGenie] +synonym: "equatorial microtubule organising centre formation" EXACT [GOC:TermGenie] +synonym: "equatorial microtubule organizing center formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0031023 ! microtubule organizing center organization + +[Term] +id: GO:1904186 +name: post-anaphase microtubule array organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array." [GOC:TermGenie, PMID:15004232] +synonym: "PAA organization" EXACT [GOC:TermGenie] +synonym: "post-anaphase array organization" EXACT [GOC:TermGenie] +synonym: "post-anaphase microtubule array organisation" EXACT [] +is_a: GO:0016043 ! cellular component organization + +[Term] +id: GO:1904187 +name: regulation of transformation of host cell by virus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] +synonym: "regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0019087 ! transformation of host cell by virus + +[Term] +id: GO:1904188 +name: negative regulation of transformation of host cell by virus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] +synonym: "down regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "down regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "down regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "downregulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "downregulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "downregulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "inhibition of transformation of host cell by virus" NARROW [GOC:TermGenie] +synonym: "inhibition of viral transformation" NARROW [GOC:TermGenie] +synonym: "inhibition of viral transformation of host cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +is_a: GO:0048525 ! negative regulation of viral process +is_a: GO:1904187 ! regulation of transformation of host cell by virus +relationship: negatively_regulates GO:0019087 ! transformation of host cell by virus + +[Term] +id: GO:1904189 +name: positive regulation of transformation of host cell by virus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transformation of host cell by virus." [GO_REF:0000058, GOC:TermGenie, PMID:12200142] +synonym: "activation of transformation of host cell by virus" NARROW [GOC:TermGenie] +synonym: "activation of viral transformation" NARROW [GOC:TermGenie] +synonym: "activation of viral transformation of host cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "up regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "up regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "up regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral transformation of host cell" EXACT [GOC:TermGenie] +synonym: "upregulation of transformation of host cell by virus" EXACT [GOC:TermGenie] +synonym: "upregulation of viral transformation" EXACT [GOC:TermGenie] +synonym: "upregulation of viral transformation of host cell" EXACT [GOC:TermGenie] +is_a: GO:0048524 ! positive regulation of viral process +is_a: GO:1904187 ! regulation of transformation of host cell by virus +relationship: positively_regulates GO:0019087 ! transformation of host cell by virus + +[Term] +id: GO:1904191 +name: positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in meiotic nuclear division +namespace: biological_process +def: "Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in meiotic nuclear division." [GO_REF:0000060, GOC:TermGenie, PMID:15791259] +synonym: "activation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie] +synonym: "positive regulation of CDK activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclin-dependent protein kinase activity involved in meiosis" BROAD [GOC:TermGenie] +synonym: "stimulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" NARROW [GOC:TermGenie] +synonym: "up regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclin-dependent protein kinase activity involved in meiotic nuclear division" EXACT [GOC:TermGenie] +is_a: GO:0040020 ! regulation of meiotic nuclear division +is_a: GO:0045737 ! positive regulation of cyclin-dependent protein serine/threonine kinase activity + +[Term] +id: GO:1904192 +name: regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:1902488 ! cholangiocyte apoptotic process + +[Term] +id: GO:1904193 +name: negative regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "down regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process +relationship: negatively_regulates GO:1902488 ! cholangiocyte apoptotic process + +[Term] +id: GO:1904194 +name: positive regulation of cholangiocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cholangiocyte apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24498161] +synonym: "activation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of cholangiocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of epithelial cell of bile duct apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cholangiocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of cholangiocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial cell of bile duct apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of epithelial cell of bile duct apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:1904192 ! regulation of cholangiocyte apoptotic process +relationship: positively_regulates GO:1902488 ! cholangiocyte apoptotic process + +[Term] +id: GO:1904195 +name: regulation of granulosa cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:1990739 ! granulosa cell proliferation + +[Term] +id: GO:1904196 +name: negative regulation of granulosa cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] +synonym: "down regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of granulosa cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:1904195 ! regulation of granulosa cell proliferation +relationship: negatively_regulates GO:1990739 ! granulosa cell proliferation + +[Term] +id: GO:1904197 +name: positive regulation of granulosa cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of granulosa cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:22383759] +synonym: "activation of granulosa cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of granulosa cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:1904195 ! regulation of granulosa cell proliferation +relationship: positively_regulates GO:1990739 ! granulosa cell proliferation + +[Term] +id: GO:1904198 +name: negative regulation of regulation of vascular associated smooth muscle cell membrane depolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] +synonym: "down regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [] +is_a: GO:1904180 ! negative regulation of membrane depolarization +relationship: negatively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization + +[Term] +id: GO:1904199 +name: positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of regulation of vascular smooth muscle cell membrane depolarization." [GO_REF:0000058, GOC:TermGenie, PMID:20826763] +synonym: "activation of regulation of vascular smooth muscle cell membrane depolarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [] +synonym: "up regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of vascular smooth muscle cell membrane depolarization" EXACT [GOC:TermGenie] +is_a: GO:1904181 ! positive regulation of membrane depolarization +relationship: positively_regulates GO:1990736 ! regulation of vascular associated smooth muscle cell membrane depolarization + +[Term] +id: GO:1904200 +name: iodide transmembrane transport +namespace: biological_process +def: "The process in which iodide is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:20392814] +is_a: GO:0015705 ! iodide transport +is_a: GO:0098661 ! inorganic anion transmembrane transport + +[Term] +id: GO:1904201 +name: regulation of iodide transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +is_a: GO:0044070 ! regulation of anion transport +relationship: regulates GO:0015705 ! iodide transport + +[Term] +id: GO:1904202 +name: negative regulation of iodide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +synonym: "down regulation of iodide transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of iodide transport" EXACT [GOC:TermGenie] +synonym: "downregulation of iodide transport" EXACT [GOC:TermGenie] +synonym: "inhibition of iodide transport" NARROW [GOC:TermGenie] +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:1904201 ! regulation of iodide transport +relationship: negatively_regulates GO:0015705 ! iodide transport + +[Term] +id: GO:1904203 +name: positive regulation of iodide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iodide transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +synonym: "activation of iodide transport" NARROW [GOC:TermGenie] +synonym: "up regulation of iodide transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of iodide transport" EXACT [GOC:TermGenie] +synonym: "upregulation of iodide transport" EXACT [GOC:TermGenie] +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:1904201 ! regulation of iodide transport +relationship: positively_regulates GO:0015705 ! iodide transport + +[Term] +id: GO:1904204 +name: regulation of skeletal muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] +is_a: GO:0014733 ! regulation of skeletal muscle adaptation +is_a: GO:0014743 ! regulation of muscle hypertrophy +relationship: regulates GO:0014734 ! skeletal muscle hypertrophy + +[Term] +id: GO:1904205 +name: negative regulation of skeletal muscle hypertrophy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] +synonym: "down regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "inhibition of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] +is_a: GO:0014741 ! negative regulation of muscle hypertrophy +is_a: GO:0014745 ! negative regulation of muscle adaptation +is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy +relationship: negatively_regulates GO:0014734 ! skeletal muscle hypertrophy + +[Term] +id: GO:1904206 +name: positive regulation of skeletal muscle hypertrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy." [GO_REF:0000058, GOC:TermGenie, PMID:23470307] +synonym: "activation of skeletal muscle hypertrophy" NARROW [GOC:TermGenie] +synonym: "up regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal muscle hypertrophy" EXACT [GOC:TermGenie] +is_a: GO:0014742 ! positive regulation of muscle hypertrophy +is_a: GO:0014744 ! positive regulation of muscle adaptation +is_a: GO:1904204 ! regulation of skeletal muscle hypertrophy +relationship: positively_regulates GO:0014734 ! skeletal muscle hypertrophy + +[Term] +id: GO:1904210 +name: VCP-NPL4-UFD1 AAA ATPase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a VCP-NPL4-UFD1 AAA ATPase complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] +synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904211 +name: membrane protein proteolysis involved in retrograde protein transport, ER to cytosol +namespace: biological_process +def: "Any membrane protein proteolysis that is involved in retrograde protein transport, ER to cytosol." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22795130] +synonym: "intramembrane cleavage of ERAD substrate" BROAD [PMID:22795130] +synonym: "intramembrane proteolysis involved in ERAD" EXACT [PMID:22795130] +synonym: "membrane protein proteolysis involved in protein dislocation from ER" EXACT [GOC:TermGenie] +synonym: "membrane protein proteolysis involved in protein retrotranslocation, ER to cytosol" EXACT [GOC:TermGenie] +synonym: "membrane protein proteolysis involved in retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [GOC:TermGenie] +is_a: GO:0033619 ! membrane protein proteolysis +is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process +relationship: part_of GO:0030970 ! retrograde protein transport, ER to cytosol + +[Term] +id: GO:1904212 +name: regulation of iodide transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +is_a: GO:1904201 ! regulation of iodide transport +relationship: regulates GO:1904200 ! iodide transmembrane transport + +[Term] +id: GO:1904213 +name: negative regulation of iodide transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +synonym: "down regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +synonym: "downregulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +synonym: "inhibition of iodide transmembrane transport" NARROW [GOC:TermGenie] +is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport +is_a: GO:1904202 ! negative regulation of iodide transport +is_a: GO:1904212 ! regulation of iodide transmembrane transport +relationship: negatively_regulates GO:1904200 ! iodide transmembrane transport + +[Term] +id: GO:1904214 +name: positive regulation of iodide transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of iodide transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:20392814] +synonym: "activation of iodide transmembrane transport" NARROW [GOC:TermGenie] +synonym: "up regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of iodide transmembrane transport" EXACT [GOC:TermGenie] +is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport +is_a: GO:1904203 ! positive regulation of iodide transport +is_a: GO:1904212 ! regulation of iodide transmembrane transport +relationship: positively_regulates GO:1904200 ! iodide transmembrane transport + +[Term] +id: GO:1904215 +name: regulation of protein import into chloroplast stroma +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] +synonym: "regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] +synonym: "regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:1903533 ! regulation of protein targeting +is_a: GO:1904589 ! regulation of protein import +relationship: regulates GO:0045037 ! protein import into chloroplast stroma + +[Term] +id: GO:1904216 +name: positive regulation of protein import into chloroplast stroma +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein import into chloroplast stroma." [GO_REF:0000058, GOC:TermGenie, PMID:25901327] +synonym: "activation of chloroplast stroma protein import" NARROW [GOC:TermGenie] +synonym: "activation of protein import into chloroplast stroma" NARROW [GOC:TermGenie] +synonym: "activation of protein transport into chloroplast stroma" NARROW [GOC:TermGenie] +synonym: "positive regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "up regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] +synonym: "up regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "up regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "up-regulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "upregulation of chloroplast stroma protein import" EXACT [GOC:TermGenie] +synonym: "upregulation of protein import into chloroplast stroma" EXACT [GOC:TermGenie] +synonym: "upregulation of protein transport into chloroplast stroma" EXACT [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1904215 ! regulation of protein import into chloroplast stroma +is_a: GO:1904591 ! positive regulation of protein import +relationship: positively_regulates GO:0045037 ! protein import into chloroplast stroma + +[Term] +id: GO:1904217 +name: regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate +synonym: "regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of serine exchange enzyme" BROAD [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904218 +name: negative regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate +synonym: "down regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine synthase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PS synthase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of PS synthase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity + +[Term] +id: GO:1904219 +name: positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CDP-diacylglycerol-serine O-phosphatidyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of availability of the substrate +synonym: "activation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDP-diglyceride-L-serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDP-diglyceride:serine phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDP-diglycerine-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CDPdiglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylserine synthase activity" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylserine synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of PS synthase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of PS synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of PS synthase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904217 ! regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity + +[Term] +id: GO:1904220 +name: regulation of serine C-palmitoyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability +synonym: "regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "regulation of serine palmitoyltransferase" BROAD [GOC:TermGenie] +synonym: "regulation of SPT" RELATED [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904221 +name: negative regulation of serine C-palmitoyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability +synonym: "down regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "down regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "down regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of SPT" RELATED [GOC:TermGenie] +synonym: "down-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "down-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of SPT" RELATED [GOC:TermGenie] +synonym: "downregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "downregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "downregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of SPT" RELATED [GOC:TermGenie] +synonym: "inhibition of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "inhibition of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of SPT" RELATED [GOC:TermGenie] +synonym: "negative regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "negative regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of SPT" RELATED [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity + +[Term] +id: GO:1904222 +name: positive regulation of serine C-palmitoyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of serine C-palmitoyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16120614] +comment: Serinc proteins form a complex with serine and sphingolipid biosynthesis enzymes and regulates their activity through regulation of the substrate availability +synonym: "activation of 3-oxosphinganine synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "activation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" NARROW [GOC:TermGenie] +synonym: "activation of serine C-palmitoyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of SPT" RELATED [GOC:TermGenie] +synonym: "positive regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "positive regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of SPT" RELATED [GOC:TermGenie] +synonym: "up regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "up regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "up regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of SPT" RELATED [GOC:TermGenie] +synonym: "up-regulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "up-regulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of SPT" RELATED [GOC:TermGenie] +synonym: "upregulation of 3-oxosphinganine synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [GOC:TermGenie] +synonym: "upregulation of palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [GOC:TermGenie] +synonym: "upregulation of serine C-palmitoyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of SPT" RELATED [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904220 ! regulation of serine C-palmitoyltransferase activity + +[Term] +id: GO:1904223 +name: regulation of glucuronosyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] +comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species +synonym: "regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904224 +name: negative regulation of glucuronosyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] +comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species +synonym: "down regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "down regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "down regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "down regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "down regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "down regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "down-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "downregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "downregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of GT activity" EXACT [GOC:TermGenie] +synonym: "downregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "downregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "downregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "downregulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "downregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "inhibition of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDPGA transferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "inhibition of UDPGT activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "negative regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904223 ! regulation of glucuronosyltransferase activity + +[Term] +id: GO:1904225 +name: positive regulation of glucuronosyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucuronosyltransferase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20610558] +comment: i2 UDP-glucuronosyltransferase splice species alter glucuronidation activity of i1 UDP-glucuronosyltransferase splice species +synonym: "activation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of GT activity" NARROW [GOC:TermGenie] +synonym: "activation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "activation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP glucuronic acid transferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" NARROW [GOC:TermGenie] +synonym: "activation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDPGA transferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDPGA-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "activation of UDPGT activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine 5'-diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphate glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "positive regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "up regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "up regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "up regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "up regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "up regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of GT activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "up-regulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 1-naphthol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 1-naphthol-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 17-OH steroid UDPGT activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 3-OH androgenic UDPGT activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 4-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of 4-nitrophenol UDPGT activity" NARROW [GOC:TermGenie] +synonym: "upregulation of bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of bilirubin monoglucuronide glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of bilirubin UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of bilirubin UDPGT activity" NARROW [GOC:TermGenie] +synonym: "upregulation of bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of ciramadol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of estriol UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of estrone UDPglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of GT activity" EXACT [GOC:TermGenie] +synonym: "upregulation of morphine glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of p-nitrophenol UDP-glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of p-nitrophenylglucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of p-phenylphenol glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of phenyl-UDP-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of PNP-UDPGT" RELATED [GOC:TermGenie] +synonym: "upregulation of pnp-UDPGT activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDP glucuronic acid transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDP glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDP glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [GOC:TermGenie] +synonym: "upregulation of UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDP-glucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDP-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDPGA transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDPGA-glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [GOC:TermGenie] +synonym: "upregulation of UDPGT activity" EXACT [GOC:TermGenie] +synonym: "upregulation of uridine 5'-diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of uridine diphosphate glucuronyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of uridine diphosphoglucuronyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904223 ! regulation of glucuronosyltransferase activity + +[Term] +id: GO:1904226 +name: regulation of glycogen synthase activity, transferring glucose-1-phosphate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904227 +name: negative regulation of glycogen synthase activity, transferring glucose-1-phosphate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] +synonym: "down regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +synonym: "downregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +synonym: "inhibition of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate + +[Term] +id: GO:1904228 +name: positive regulation of glycogen synthase activity, transferring glucose-1-phosphate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycogen synthase activity, transferring glucose-1-phosphate." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17569761] +synonym: "activation of glycogen synthase activity, transferring glucose-1-phosphate" NARROW [GOC:TermGenie] +synonym: "up regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +synonym: "upregulation of glycogen synthase activity, transferring glucose-1-phosphate" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904226 ! regulation of glycogen synthase activity, transferring glucose-1-phosphate + +[Term] +id: GO:1904229 +name: regulation of succinate dehydrogenase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinic dehydrogenase activity" BROAD [GOC:TermGenie] +synonym: "regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1904230 +name: negative regulation of succinate dehydrogenase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "down regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of fumarate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of fumarate reductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of fumaric hydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinate oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinodehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of succinyl dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1904229 ! regulation of succinate dehydrogenase activity + +[Term] +id: GO:1904231 +name: positive regulation of succinate dehydrogenase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "activation of fumarate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of fumarate reductase activity" NARROW [GOC:TermGenie] +synonym: "activation of fumaric hydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinate dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinate oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinate:(acceptor) oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinate:acceptor oxidoreductase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinic acid dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinodehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "activation of succinyl dehydrogenase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of fumarate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of fumarate reductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of fumaric hydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinate dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinate oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinate:(acceptor) oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinate:acceptor oxidoreductase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinic acid dehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinodehydrogenase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of succinyl dehydrogenase activity" EXACT [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1904229 ! regulation of succinate dehydrogenase activity + +[Term] +id: GO:1904232 +name: regulation of aconitate hydratase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "regulation of citrate hydro-lyase activity" BROAD [GOC:TermGenie] +synonym: "regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +is_a: GO:0051339 ! regulation of lyase activity + +[Term] +id: GO:1904233 +name: negative regulation of aconitate hydratase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "down regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of aconitase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of aconitate hydratase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cis-aconitase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +is_a: GO:0051350 ! negative regulation of lyase activity +is_a: GO:1904232 ! regulation of aconitate hydratase activity + +[Term] +id: GO:1904234 +name: positive regulation of aconitate hydratase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity." [GO_REF:0000059, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18160053] +synonym: "activation of aconitase activity" NARROW [GOC:TermGenie] +synonym: "activation of aconitate hydratase activity" NARROW [GOC:TermGenie] +synonym: "activation of cis-aconitase activity" NARROW [GOC:TermGenie] +synonym: "activation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" NARROW [GOC:TermGenie] +synonym: "activation of citrate(isocitrate) hydro-lyase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aconitase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aconitate hydratase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cis-aconitase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of citrate(isocitrate) hydro-lyase activity" EXACT [GOC:TermGenie] +is_a: GO:0051349 ! positive regulation of lyase activity +is_a: GO:1904232 ! regulation of aconitate hydratase activity + +[Term] +id: GO:1904235 +name: regulation of substrate-dependent cell migration, cell attachment to substrate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] +synonym: "regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +is_a: GO:0010810 ! regulation of cell-substrate adhesion +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate + +[Term] +id: GO:1904236 +name: negative regulation of substrate-dependent cell migration, cell attachment to substrate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] +synonym: "down regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "down regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "down-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "down-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "downregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "downregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "inhibition of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] +synonym: "inhibition of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] +synonym: "negative regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +is_a: GO:0010812 ! negative regulation of cell-substrate adhesion +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate +relationship: negatively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate + +[Term] +id: GO:1904237 +name: positive regulation of substrate-dependent cell migration, cell attachment to substrate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate." [GO_REF:0000058, GOC:TermGenie, PMID:25834989] +synonym: "activation of substrate-bound cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] +synonym: "activation of substrate-dependent cell migration, cell attachment to substrate" NARROW [GOC:TermGenie] +synonym: "positive regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "up regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "up regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "up-regulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "up-regulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "upregulation of substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +synonym: "upregulation of substrate-dependent cell migration, cell attachment to substrate" EXACT [GOC:TermGenie] +is_a: GO:0010811 ! positive regulation of cell-substrate adhesion +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:1904235 ! regulation of substrate-dependent cell migration, cell attachment to substrate +relationship: positively_regulates GO:0006931 ! substrate-dependent cell migration, cell attachment to substrate + +[Term] +id: GO:1904238 +name: pericyte cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a pericyte cell." [GO_REF:0000086, GOC:dph, GOC:TermGenie, PMID:23868830] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:1904239 +name: regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly + +[Term] +id: GO:1904240 +name: negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] +synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "down regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "downregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly +relationship: negatively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly + +[Term] +id: GO:1904241 +name: positive regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of VCP-NPL4-UFD1 AAA ATPase complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "activation of p97-Ufd1-Npl4 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of p97-Ufd1-Npl4 complex formation" NARROW [GOC:TermGenie] +synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of VCP-NPL4-UFD1 AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "up regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of Cdc48p-Npl4p-Ufd1p AAA ATPase complex formation" NARROW [GOC:TermGenie] +synonym: "upregulation of p97-Ufd1-Npl4 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of p97-Ufd1-Npl4 complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of VCP-NPL4-UFD1 AAA ATPase complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1904239 ! regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly +relationship: positively_regulates GO:1904210 ! VCP-NPL4-UFD1 AAA ATPase complex assembly + +[Term] +id: GO:1904242 +name: regulation of pancreatic trypsinogen secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] +synonym: "regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:1990747 ! pancreatic trypsinogen secretion + +[Term] +id: GO:1904243 +name: negative regulation of pancreatic trypsinogen secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] +synonym: "down regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "down regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "down-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "downregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of pancreatic trypsinogen release" NARROW [GOC:TermGenie] +synonym: "inhibition of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion +relationship: negatively_regulates GO:1990747 ! pancreatic trypsinogen secretion + +[Term] +id: GO:1904244 +name: positive regulation of pancreatic trypsinogen secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic trypsinogen secretion." [GO_REF:0000058, GOC:TermGenie, PMID:12771515] +synonym: "activation of pancreatic trypsinogen release" NARROW [GOC:TermGenie] +synonym: "activation of pancreatic trypsinogen secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "up regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "up regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic trypsinogen release" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic trypsinogen secretion" EXACT [GOC:TermGenie] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:1904242 ! regulation of pancreatic trypsinogen secretion +relationship: positively_regulates GO:1990747 ! pancreatic trypsinogen secretion + +[Term] +id: GO:1904245 +name: regulation of polynucleotide adenylyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] +synonym: "regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904246 +name: negative regulation of polynucleotide adenylyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] +synonym: "down regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "down regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "down-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "downregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NTP polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of poly(A) hydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of poly(A) polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of poly(A) synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of poly-A polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polyadenylate polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polyadenylate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polyadenylic polymerase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA adenylating enzyme activity" NARROW [GOC:TermGenie] +synonym: "inhibition of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "inhibition of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "negative regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity + +[Term] +id: GO:1904247 +name: positive regulation of polynucleotide adenylyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of polynucleotide adenylyltransferase activity." [GO_REF:0000059, GOC:kmv, GOC:TermGenie, PMID:19460348] +synonym: "activation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of AMP polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP-polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP:polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP:polynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of NTP polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of poly(A) hydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of poly(A) polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of poly(A) synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of poly-A polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of polyadenylate nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of polyadenylate polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of polyadenylate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of polyadenylic acid polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of polyadenylic polymerase activity" NARROW [GOC:TermGenie] +synonym: "activation of polynucleotide adenylyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of RNA adenylating enzyme activity" NARROW [GOC:TermGenie] +synonym: "activation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "activation of terminal riboadenylate transferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "positive regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "up regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "up-regulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of AMP polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP-polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP:polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP:polynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NTP polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(A) hydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(A) polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly(A) synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of poly-A polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polyadenylate nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polyadenylate polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polyadenylate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polyadenylic acid polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polyadenylic polymerase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of polynucleotide adenylyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA adenylating enzyme activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA formation factors, PF1" RELATED [GOC:TermGenie] +synonym: "upregulation of terminal riboadenylate transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904245 ! regulation of polynucleotide adenylyltransferase activity + +[Term] +id: GO:1904248 +name: regulation of age-related resistance +namespace: biological_process +def: "Any process that modulates the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] +synonym: "regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "regulation of ARR" EXACT [GOC:TermGenie] +synonym: "regulation of developmental resistance" BROAD [GOC:TermGenie] +synonym: "regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "regulation of ontogenic resistance" BROAD [GOC:TermGenie] +synonym: "regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0090644 ! age-related resistance + +[Term] +id: GO:1904249 +name: negative regulation of age-related resistance +namespace: biological_process +def: "Any process that stops, prevents or reduces the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] +synonym: "down regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "down regulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "down regulation of ARR" EXACT [GOC:TermGenie] +synonym: "down regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "down regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "down regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "down-regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "down-regulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "down-regulation of ARR" EXACT [GOC:TermGenie] +synonym: "down-regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "down-regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "down-regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "downregulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "downregulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "downregulation of ARR" EXACT [GOC:TermGenie] +synonym: "downregulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "downregulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "downregulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "inhibition of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "inhibition of age-related resistance" NARROW [GOC:TermGenie] +synonym: "inhibition of ARR" NARROW [GOC:TermGenie] +synonym: "inhibition of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "inhibition of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "inhibition of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "negative regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "negative regulation of ARR" EXACT [GOC:TermGenie] +synonym: "negative regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "negative regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "negative regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1904248 ! regulation of age-related resistance +relationship: negatively_regulates GO:0090644 ! age-related resistance + +[Term] +id: GO:1904250 +name: positive regulation of age-related resistance +namespace: biological_process +def: "Any process that activates or increases the extent of age-related resistance." [GO_REF:0000058, GOC:TermGenie, PMID:19694953] +synonym: "activation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "activation of age-related resistance" NARROW [GOC:TermGenie] +synonym: "activation of ARR" NARROW [GOC:TermGenie] +synonym: "activation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "activation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "activation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "positive regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "positive regulation of ARR" EXACT [GOC:TermGenie] +synonym: "positive regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "positive regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "positive regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "up regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "up regulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "up regulation of ARR" EXACT [GOC:TermGenie] +synonym: "up regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "up regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "up regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "up-regulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "up-regulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "up-regulation of ARR" EXACT [GOC:TermGenie] +synonym: "up-regulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "up-regulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "up-regulation of senescence-induced resistance" NARROW [GOC:TermGenie] +synonym: "upregulation of adult seedling resistance" NARROW [GOC:TermGenie] +synonym: "upregulation of age-related resistance" EXACT [GOC:TermGenie] +synonym: "upregulation of ARR" EXACT [GOC:TermGenie] +synonym: "upregulation of flowering-induced resistance" NARROW [GOC:TermGenie] +synonym: "upregulation of mature seedling resistance" NARROW [GOC:TermGenie] +synonym: "upregulation of senescence-induced resistance" NARROW [GOC:TermGenie] +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1904248 ! regulation of age-related resistance +relationship: positively_regulates GO:0090644 ! age-related resistance + +[Term] +id: GO:1904251 +name: regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "regulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019218 ! regulation of steroid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0008206 ! bile acid metabolic process + +[Term] +id: GO:1904252 +name: negative regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "down regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of bile acid metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of bile acid metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0045939 ! negative regulation of steroid metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +relationship: negatively_regulates GO:0008206 ! bile acid metabolic process + +[Term] +id: GO:1904253 +name: positive regulation of bile acid metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bile acid metabolic process." [GO_REF:0000058, GOC:bf, GOC:TermGenie] +synonym: "activation of bile acid metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of bile acid metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of bile acid metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of bile acid metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of bile acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0045940 ! positive regulation of steroid metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1904251 ! regulation of bile acid metabolic process +relationship: positively_regulates GO:0008206 ! bile acid metabolic process + +[Term] +id: GO:1904254 +name: regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of iron channel activity" EXACT [] +synonym: "regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:0034759 ! regulation of iron ion transmembrane transport + +[Term] +id: GO:1904255 +name: negative regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "down regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of iron cation channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iron channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of iron-specific channel activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of iron channel activity" EXACT [] +synonym: "negative regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity + +[Term] +id: GO:1904256 +name: positive regulation of iron ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "activation of iron cation channel activity" NARROW [GOC:TermGenie] +synonym: "activation of iron channel activity" NARROW [GOC:TermGenie] +synonym: "activation of iron-specific channel activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of iron channel activity" EXACT [] +synonym: "positive regulation of iron transmembrane transporter activity" EXACT [] +synonym: "positive regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of iron-specific channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron cation channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of iron-specific channel activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904254 ! regulation of iron ion transmembrane transporter activity + +[Term] +id: GO:1904257 +name: zinc ion import into Golgi apparatus +namespace: biological_process +def: "The directed import of zinc(2+) from the cytosol across the Golgi membrane into the Golgi apparatus." [GO_REF:0000075, GOC:TermGenie, PMID:25732056] +synonym: "zinc II ion import across Golgi membrane" EXACT [] +synonym: "zinc ion import across Golgi membrane" EXACT [] +synonym: "zinc ion import into Golgi membrane" RELATED [] +synonym: "zinc(2+) import across Golgi membrane" EXACT [] +is_a: GO:0062111 ! zinc ion import into organelle + +[Term] +id: GO:1904258 +name: nuclear dicing body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a nuclear dicing body." [GO_REF:0000079, GOC:TermGenie, PMID:25902521] +synonym: "D body assembly" EXACT [GOC:TermGenie] +synonym: "D body formation" EXACT [GOC:TermGenie] +synonym: "nuclear dicing body formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0030575 ! nuclear body organization + +[Term] +id: GO:1904259 +name: regulation of basement membrane assembly involved in embryonic body morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0110011 ! regulation of basement membrane organization +is_a: GO:1901201 ! regulation of extracellular matrix assembly +relationship: regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis + +[Term] +id: GO:1904260 +name: negative regulation of basement membrane assembly involved in embryonic body morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] +synonym: "down regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1901202 ! negative regulation of extracellular matrix assembly +is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis +relationship: negatively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis + +[Term] +id: GO:1904261 +name: positive regulation of basement membrane assembly involved in embryonic body morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:23940118] +synonym: "activation of basement membrane assembly involved in embryonic body morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of basement membrane assembly involved in embryonic body morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1901203 ! positive regulation of extracellular matrix assembly +is_a: GO:1904259 ! regulation of basement membrane assembly involved in embryonic body morphogenesis +relationship: positively_regulates GO:2001197 ! basement membrane assembly involved in embryonic body morphogenesis + +[Term] +id: GO:1904262 +name: negative regulation of TORC1 signaling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275] +synonym: "down regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "down regulation of TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "down-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "down-regulation of TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "downregulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "downregulation of TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "inhibition of TORC1 signal transduction" NARROW [GOC:TermGenie] +synonym: "inhibition of TORC1 signaling" NARROW [GOC:TermGenie] +synonym: "negative regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +is_a: GO:0032007 ! negative regulation of TOR signaling +is_a: GO:1903432 ! regulation of TORC1 signaling +relationship: negatively_regulates GO:0038202 ! TORC1 signaling + +[Term] +id: GO:1904263 +name: positive regulation of TORC1 signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TORC1 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25366275] +synonym: "activation of TORC1 signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of TORC1 signaling" NARROW [GOC:TermGenie] +synonym: "positive regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of TORC1 signaling" EXACT [GOC:TermGenie] +is_a: GO:0032008 ! positive regulation of TOR signaling +is_a: GO:1903432 ! regulation of TORC1 signaling +relationship: positively_regulates GO:0038202 ! TORC1 signaling + +[Term] +id: GO:1904266 +name: regulation of Schwann cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] +is_a: GO:0050920 ! regulation of chemotaxis +is_a: GO:1900147 ! regulation of Schwann cell migration +relationship: regulates GO:1990751 ! Schwann cell chemotaxis + +[Term] +id: GO:1904267 +name: negative regulation of Schwann cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] +synonym: "down regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +synonym: "downregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +synonym: "inhibition of Schwann cell chemotaxis" NARROW [GOC:TermGenie] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:1900148 ! negative regulation of Schwann cell migration +is_a: GO:1904266 ! regulation of Schwann cell chemotaxis +relationship: negatively_regulates GO:1990751 ! Schwann cell chemotaxis + +[Term] +id: GO:1904268 +name: positive regulation of Schwann cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:16203995] +synonym: "activation of Schwann cell chemotaxis" NARROW [GOC:TermGenie] +synonym: "up regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +synonym: "upregulation of Schwann cell chemotaxis" EXACT [GOC:TermGenie] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1900149 ! positive regulation of Schwann cell migration +is_a: GO:1904266 ! regulation of Schwann cell chemotaxis +relationship: positively_regulates GO:1990751 ! Schwann cell chemotaxis + +[Term] +id: GO:1904269 +name: cell leading edge cell cortex +namespace: cellular_component +def: "The cell cortex of the leading edge of a cell." [GO_REF:0000064, GOC:kmv, GOC:TermGenie, PMID:25843030] +synonym: "cell cortex of cell leading edge" EXACT [GOC:TermGenie] +synonym: "cell cortex of front of cell" EXACT [GOC:TermGenie] +synonym: "cell cortex of leading edge of cell" EXACT [GOC:TermGenie] +synonym: "cell periphery of cell leading edge" RELATED [GOC:TermGenie] +synonym: "cell periphery of front of cell" RELATED [GOC:TermGenie] +synonym: "cell periphery of leading edge of cell" RELATED [GOC:TermGenie] +synonym: "peripheral cytoplasm of cell leading edge" RELATED [GOC:TermGenie] +synonym: "peripheral cytoplasm of front of cell" RELATED [GOC:TermGenie] +synonym: "peripheral cytoplasm of leading edge of cell" RELATED [GOC:TermGenie] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0031252 ! cell leading edge + +[Term] +id: GO:1904270 +name: pyroptosome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a pyroptosome complex." [GO_REF:0000079, GOC:TermGenie, PMID:17964261] +synonym: "ASC pyroptosome assembly" EXACT [GOC:TermGenie] +synonym: "ASC pyroptosome formation" EXACT [GOC:TermGenie] +synonym: "pyroptosome complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904271 +name: L-proline import across plasma membrane +namespace: biological_process +alt_id: GO:1903809 +def: "The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] +synonym: "L-proline import into cell" EXACT [] +is_a: GO:1904555 ! L-proline transmembrane transport +is_a: GO:1905647 ! proline import across plasma membrane + +[Term] +id: GO:1904272 +name: L-tryptophan import across plasma membrane +namespace: biological_process +def: "The directed movement of L-tryptophan from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:1904556 ! L-tryptophan transmembrane transport + +[Term] +id: GO:1904273 +name: L-alanine import across plasma membrane +namespace: biological_process +def: "The directed import of L-alanine from the extracellular region across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:kmv, GOC:TermGenie, PMID:21097500] +is_a: GO:0089718 ! amino acid import across plasma membrane +is_a: GO:1904557 ! L-alanine transmembrane transport + +[Term] +id: GO:1904274 +name: tricellular tight junction assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a tricellular tight junction." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962] +synonym: "tricellular tight junction formation" EXACT [GOC:TermGenie] +is_a: GO:0120192 ! tight junction assembly + +[Term] +id: GO:1904275 +name: tricellular tight junction disassembly +namespace: biological_process +def: "The disaggregation of a tricellular tight junction into its constituent components." [GO_REF:0000079, GOC:mr, GOC:TermGenie, PMID:22640933, PMID:25097825, PMID:4203962] +is_a: GO:1905071 ! tight junction disassembly + +[Term] +id: GO:1904276 +name: regulation of wax biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] +synonym: "regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "regulation of wax synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009889 ! regulation of biosynthetic process +relationship: regulates GO:0010025 ! wax biosynthetic process + +[Term] +id: GO:1904277 +name: negative regulation of wax biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] +synonym: "down regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "down regulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of wax formation" EXACT [GOC:TermGenie] +synonym: "downregulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of wax anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of wax biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of wax biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of wax formation" NARROW [GOC:TermGenie] +synonym: "inhibition of wax synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of wax synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:1904276 ! regulation of wax biosynthetic process +relationship: negatively_regulates GO:0010025 ! wax biosynthetic process + +[Term] +id: GO:1904278 +name: positive regulation of wax biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of wax biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24692420] +synonym: "activation of wax anabolism" NARROW [GOC:TermGenie] +synonym: "activation of wax biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of wax biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of wax formation" NARROW [GOC:TermGenie] +synonym: "activation of wax synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "up regulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of wax formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of wax synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of wax anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of wax biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of wax biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of wax formation" EXACT [GOC:TermGenie] +synonym: "upregulation of wax synthesis" EXACT [GOC:TermGenie] +is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:1904276 ! regulation of wax biosynthetic process +relationship: positively_regulates GO:0010025 ! wax biosynthetic process + +[Term] +id: GO:1904279 +name: regulation of transcription by RNA polymerase V +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] +synonym: "regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "regulation of transcription from RNA polymerase V promoter" EXACT [] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0001060 ! transcription by RNA polymerase V + +[Term] +id: GO:1904280 +name: negative regulation of transcription by RNA polymerase V +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] +synonym: "down regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of transcription from RNA pol V promoter" NARROW [GOC:TermGenie] +synonym: "inhibition of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of transcription from RNA polymerase V promoter" EXACT [] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:1904279 ! regulation of transcription by RNA polymerase V +relationship: negatively_regulates GO:0001060 ! transcription by RNA polymerase V + +[Term] +id: GO:1904281 +name: positive regulation of transcription by RNA polymerase V +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V." [GO_REF:0000058, GOC:TermGenie, PMID:24726328] +synonym: "activation of transcription from RNA pol V promoter" NARROW [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase V promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase V promoter" EXACT [] +synonym: "up regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA pol V promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase V promoter" EXACT [GOC:TermGenie] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:1904279 ! regulation of transcription by RNA polymerase V +relationship: positively_regulates GO:0001060 ! transcription by RNA polymerase V + +[Term] +id: GO:1904282 +name: regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] +synonym: "regulation of antigen presentation, endogenous peptide antigen" BROAD [GOC:TermGenie] +synonym: "regulation of antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [GOC:TermGenie] +synonym: "regulation of antigen processing, endogenous antigen via MHC class I" BROAD [GOC:TermGenie] +synonym: "regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I +relationship: regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:1904283 +name: negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] +synonym: "down regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "down regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "down-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "down-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "downregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "downregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "inhibition of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie] +synonym: "inhibition of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie] +synonym: "negative regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +is_a: GO:0002590 ! negative regulation of antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I +relationship: negatively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:1904284 +name: positive regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antigen processing and presentation of endogenous peptide antigen via MHC class I." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:24643698] +synonym: "activation of antigen processing and presentation of endogenous peptide antigen via MHC class I" NARROW [GOC:TermGenie] +synonym: "activation of endogenous peptide antigen processing and presentation via MHC class I" NARROW [GOC:TermGenie] +synonym: "positive regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "up regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "up regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "up-regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "up-regulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +synonym: "upregulation of antigen processing and presentation of endogenous peptide antigen via MHC class I" EXACT [GOC:TermGenie] +synonym: "upregulation of endogenous peptide antigen processing and presentation via MHC class I" EXACT [GOC:TermGenie] +is_a: GO:0002591 ! positive regulation of antigen processing and presentation of peptide antigen via MHC class I +is_a: GO:1904282 ! regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I +relationship: positively_regulates GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I + +[Term] +id: GO:1904285 +name: regulation of protein-pyridoxal-5-phosphate linkage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage + +[Term] +id: GO:1904286 +name: negative regulation of protein-pyridoxal-5-phosphate linkage +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] +synonym: "down regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +synonym: "downregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +synonym: "inhibition of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage +relationship: negatively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage + +[Term] +id: GO:1904287 +name: positive regulation of protein-pyridoxal-5-phosphate linkage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." [GO_REF:0000058, GOC:TermGenie, PMID:25957689] +synonym: "activation of protein-pyridoxal-5-phosphate linkage" NARROW [GOC:TermGenie] +synonym: "stimulation of protein-pyridoxal-5-phosphate linkage" EXACT [] +synonym: "up regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +synonym: "upregulation of protein-pyridoxal-5-phosphate linkage" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1904285 ! regulation of protein-pyridoxal-5-phosphate linkage +relationship: positively_regulates GO:0018352 ! protein-pyridoxal-5-phosphate linkage + +[Term] +id: GO:1904288 +name: BAT3 complex binding +namespace: molecular_function +def: "Binding to a BAT3 complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23246001] +synonym: "Bag6 complex binding" EXACT [GOC:TermGenie] +synonym: "BAG6-UBL4A-TRC35 complex binding" EXACT [GOC:TermGenie] +synonym: "BAT3-TRC35-UBL4A complex binding" RELATED [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904289 +name: regulation of mitotic DNA damage checkpoint +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:2000001 ! regulation of DNA damage checkpoint +relationship: regulates GO:0044773 ! mitotic DNA damage checkpoint signaling + +[Term] +id: GO:1904290 +name: negative regulation of mitotic DNA damage checkpoint +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] +synonym: "down regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0045931 ! positive regulation of mitotic cell cycle +is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint +is_a: GO:2000002 ! negative regulation of DNA damage checkpoint +relationship: negatively_regulates GO:0044773 ! mitotic DNA damage checkpoint signaling + +[Term] +id: GO:1904291 +name: positive regulation of mitotic DNA damage checkpoint +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic DNA damage checkpoint." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:16549501] +synonym: "activation of mitotic DNA damage checkpoint" NARROW [GOC:TermGenie] +synonym: "up regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic DNA damage checkpoint" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1904289 ! regulation of mitotic DNA damage checkpoint +is_a: GO:2000003 ! positive regulation of DNA damage checkpoint +relationship: positively_regulates GO:0044773 ! mitotic DNA damage checkpoint signaling + +[Term] +id: GO:1904292 +name: regulation of ERAD pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +is_a: GO:0061136 ! regulation of proteasomal protein catabolic process +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +relationship: regulates GO:0036503 ! ERAD pathway + +[Term] +id: GO:1904293 +name: negative regulation of ERAD pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22590560] +synonym: "down regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of ERAD pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of ERAD pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of ERAD pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of ERAD pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process +is_a: GO:1903573 ! negative regulation of response to endoplasmic reticulum stress +is_a: GO:1904292 ! regulation of ERAD pathway +relationship: negatively_regulates GO:0036503 ! ERAD pathway + +[Term] +id: GO:1904294 +name: positive regulation of ERAD pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ERAD pathway." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of endoplasmic reticulum-associated degradation" NARROW [GOC:TermGenie] +synonym: "activation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "activation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "activation of ERAD pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of ERAD pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of ERAD pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of ERAD pathway" EXACT [GOC:TermGenie] +is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process +is_a: GO:1904292 ! regulation of ERAD pathway +is_a: GO:1905898 ! positive regulation of response to endoplasmic reticulum stress +relationship: positively_regulates GO:0036503 ! ERAD pathway + +[Term] +id: GO:1904295 +name: regulation of osmolarity-sensing cation channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1904296 +name: negative regulation of osmolarity-sensing cation channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] +synonym: "down regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +synonym: "inhibition of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie] +is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1904297 +name: positive regulation of osmolarity-sensing cation channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osmolarity-sensing cation channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:18279313] +synonym: "activation of osmolarity-sensing cation channel activity" NARROW [GOC:TermGenie] +synonym: "up regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of osmolarity-sensing cation channel activity" EXACT [GOC:TermGenie] +is_a: GO:1904295 ! regulation of osmolarity-sensing cation channel activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1904298 +name: regulation of transcytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0045056 ! transcytosis + +[Term] +id: GO:1904299 +name: negative regulation of transcytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] +synonym: "down regulation of transcytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of transcytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of transcytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of transcytosis" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904298 ! regulation of transcytosis +relationship: negatively_regulates GO:0045056 ! transcytosis + +[Term] +id: GO:1904300 +name: positive regulation of transcytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcytosis." [GO_REF:0000058, GOC:TermGenie, PMID:9664076] +synonym: "activation of transcytosis" NARROW [GOC:TermGenie] +synonym: "up regulation of transcytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of transcytosis" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904298 ! regulation of transcytosis +relationship: positively_regulates GO:0045056 ! transcytosis + +[Term] +id: GO:1904301 +name: regulation of maternal process involved in parturition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060137 ! maternal process involved in parturition + +[Term] +id: GO:1904302 +name: negative regulation of maternal process involved in parturition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] +synonym: "down regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +synonym: "down-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +synonym: "downregulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +synonym: "inhibition of maternal process involved in parturition" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904301 ! regulation of maternal process involved in parturition +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0060137 ! maternal process involved in parturition + +[Term] +id: GO:1904303 +name: positive regulation of maternal process involved in parturition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition." [GO_REF:0000058, GOC:TermGenie, PMID:1849751] +synonym: "activation of maternal process involved in parturition" NARROW [GOC:TermGenie] +synonym: "up regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +synonym: "up-regulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +synonym: "upregulation of maternal process involved in parturition" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904301 ! regulation of maternal process involved in parturition +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0060137 ! maternal process involved in parturition + +[Term] +id: GO:1904304 +name: regulation of gastro-intestinal system smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] +is_a: GO:0006940 ! regulation of smooth muscle contraction +relationship: regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:1904305 +name: negative regulation of gastro-intestinal system smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] +synonym: "down regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: negatively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:1904306 +name: positive regulation of gastro-intestinal system smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:10821044] +synonym: "activation of gastro-intestinal system smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of gastro-intestinal system smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: positively_regulates GO:0014831 ! gastro-intestinal system smooth muscle contraction + +[Term] +id: GO:1904307 +name: response to desipramine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1904308 +name: cellular response to desipramine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20549303] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904307 ! response to desipramine + +[Term] +id: GO:1904309 +name: response to cordycepin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] +synonym: "response to 3'-deoxyadenosine" EXACT [GOC:sl] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904310 +name: cellular response to cordycepin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cordycepin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21597460] +synonym: "cellular response to 3'-deoxyadenosine" EXACT [GOC:sl] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904309 ! response to cordycepin + +[Term] +id: GO:1904311 +name: response to gold(3+) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:1904312 +name: cellular response to gold(3+) +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold(3+) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16206274] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904311 ! response to gold(3+) + +[Term] +id: GO:1904313 +name: response to methamphetamine hydrochloride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933] +synonym: "response to methamphetamine HCL" EXACT [] +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:1904314 +name: cellular response to methamphetamine hydrochloride +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methamphetamine hydrochloride stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22174933] +synonym: "cellular response to methamphetamine HCL" EXACT [] +is_a: GO:1902075 ! cellular response to salt +is_a: GO:1904313 ! response to methamphetamine hydrochloride + +[Term] +id: GO:1904315 +name: transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, PMID:20200227] +subset: goslim_synapse +synonym: "ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential" NARROW [GOC:TermGenie] +synonym: "ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential" NARROW [GOC:TermGenie] +is_a: GO:0022824 ! transmitter-gated ion channel activity +is_a: GO:0099529 ! neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential + +[Term] +id: GO:1904316 +name: response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918] +synonym: "response to PAF" EXACT [] +synonym: "response to platelet-activating factor" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0033993 ! response to lipid +is_a: GO:0045472 ! response to ether +is_a: GO:0046683 ! response to organophosphorus + +[Term] +id: GO:1904317 +name: cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9321918] +synonym: "cellular response to PAF" EXACT [] +synonym: "cellular response to platelet-activating factor" EXACT [] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904316 ! response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine + +[Term] +id: GO:1904318 +name: regulation of smooth muscle contraction involved in micturition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] +synonym: "regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +is_a: GO:0006940 ! regulation of smooth muscle contraction +is_a: GO:0044062 ! regulation of excretion +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0060083 ! smooth muscle contraction involved in micturition + +[Term] +id: GO:1904319 +name: negative regulation of smooth muscle contraction involved in micturition +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] +synonym: "down regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "down regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "down regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "down-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "down-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "down-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "downregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "downregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "downregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "inhibition of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] +synonym: "inhibition of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "inhibition of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "negative regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "negative regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition +relationship: negatively_regulates GO:0060083 ! smooth muscle contraction involved in micturition + +[Term] +id: GO:1904320 +name: positive regulation of smooth muscle contraction involved in micturition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition." [GO_REF:0000058, GOC:TermGenie, PMID:18562635] +synonym: "activation of smooth muscle contraction involved in micturition" NARROW [GOC:TermGenie] +synonym: "activation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "activation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "positive regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "positive regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "up regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "up regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "up regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "up-regulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "up-regulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +synonym: "upregulation of smooth muscle contraction involved in micturition" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle contraction involved in urination" RELATED [GOC:TermGenie] +synonym: "upregulation of urinary bladder smooth muscle contraction involved in micturition" RELATED [GOC:TermGenie] +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +is_a: GO:1904318 ! regulation of smooth muscle contraction involved in micturition +relationship: positively_regulates GO:0060083 ! smooth muscle contraction involved in micturition + +[Term] +id: GO:1904321 +name: response to forskolin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904322 +name: cellular response to forskolin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a forskolin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:15937517] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904321 ! response to forskolin + +[Term] +id: GO:1904323 +name: regulation of inhibitory G protein-coupled receptor phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] +synonym: "regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] +is_a: GO:0001932 ! regulation of protein phosphorylation +relationship: regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation + +[Term] +id: GO:1904324 +name: negative regulation of inhibitory G protein-coupled receptor phosphorylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] +synonym: "down regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +synonym: "inhibition of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] +is_a: GO:0001933 ! negative regulation of protein phosphorylation +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation +relationship: negatively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation + +[Term] +id: GO:1904325 +name: positive regulation of inhibitory G protein-coupled receptor phosphorylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation." [GO_REF:0000058, GOC:TermGenie, PMID:15937517] +synonym: "activation of inhibitory G-protein coupled receptor phosphorylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [] +synonym: "up regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibitory G-protein coupled receptor phosphorylation" EXACT [GOC:TermGenie] +is_a: GO:0001934 ! positive regulation of protein phosphorylation +is_a: GO:1904323 ! regulation of inhibitory G protein-coupled receptor phosphorylation +relationship: positively_regulates GO:0002030 ! inhibitory G protein-coupled receptor phosphorylation + +[Term] +id: GO:1904326 +name: negative regulation of circadian sleep/wake cycle, wakefulness +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of circadian sleep/wake cycle, wakefulness." [GO_REF:0000058, GOC:TermGenie, PMID:10923657] +synonym: "down regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] +synonym: "down-regulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] +synonym: "downregulation of circadian sleep/wake cycle, wakefulness" EXACT [GOC:TermGenie] +synonym: "inhibition of circadian sleep/wake cycle, wakefulness" NARROW [GOC:TermGenie] +is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness +is_a: GO:0042754 ! negative regulation of circadian rhythm +is_a: GO:0048521 ! negative regulation of behavior +relationship: negatively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness + +[Term] +id: GO:1904327 +name: protein localization to cytosolic proteasome complex +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cytosolic proteasome complex." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17000876] +synonym: "protein localisation in cytosolic proteasome complex" EXACT [GOC:TermGenie] +synonym: "protein localisation to cytosolic proteasome complex" EXACT [GOC:TermGenie] +synonym: "protein localization in cytosolic proteasome complex" EXACT [GOC:TermGenie] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:1904328 +name: regulation of myofibroblast contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] +synonym: "regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "regulation of MFB contraction" EXACT [GOC:TermGenie] +is_a: GO:1903115 ! regulation of actin filament-based movement +relationship: regulates GO:1990764 ! myofibroblast contraction + +[Term] +id: GO:1904329 +name: negative regulation of myofibroblast contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] +synonym: "down regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "down regulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "down regulation of myofibroblast contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of myofibroblast contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of myofibroblast contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of MF contraction" NARROW [GOC:TermGenie] +synonym: "inhibition of MFB contraction" NARROW [GOC:TermGenie] +synonym: "inhibition of myofibroblast contraction" NARROW [GOC:TermGenie] +synonym: "negative regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "negative regulation of MFB contraction" EXACT [GOC:TermGenie] +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1904328 ! regulation of myofibroblast contraction +relationship: negatively_regulates GO:1990764 ! myofibroblast contraction + +[Term] +id: GO:1904330 +name: positive regulation of myofibroblast contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myofibroblast contraction." [GO_REF:0000058, GOC:TermGenie, PMID:19239477] +synonym: "activation of MF contraction" NARROW [GOC:TermGenie] +synonym: "activation of MFB contraction" NARROW [GOC:TermGenie] +synonym: "activation of myofibroblast contraction" NARROW [GOC:TermGenie] +synonym: "positive regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "positive regulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "up regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "up regulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "up regulation of myofibroblast contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of myofibroblast contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of MF contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of MFB contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of myofibroblast contraction" EXACT [GOC:TermGenie] +is_a: GO:1903116 ! positive regulation of actin filament-based movement +is_a: GO:1904328 ! regulation of myofibroblast contraction +relationship: positively_regulates GO:1990764 ! myofibroblast contraction + +[Term] +id: GO:1904331 +name: regulation of error-prone translesion synthesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] +synonym: "regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "regulation of mutagenic PRR" EXACT [GOC:TermGenie] +is_a: GO:0006282 ! regulation of DNA repair +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: regulates GO:0042276 ! error-prone translesion synthesis + +[Term] +id: GO:1904332 +name: negative regulation of error-prone translesion synthesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] +synonym: "down regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "down regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "down regulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "down-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "down-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "down-regulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "downregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "downregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "downregulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "inhibition of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "inhibition of error-prone translesion synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "inhibition of mutagenic PRR" NARROW [GOC:TermGenie] +synonym: "negative regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "negative regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "negative regulation of mutagenic PRR" EXACT [GOC:TermGenie] +is_a: GO:0045738 ! negative regulation of DNA repair +is_a: GO:1904331 ! regulation of error-prone translesion synthesis +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process +relationship: negatively_regulates GO:0042276 ! error-prone translesion synthesis + +[Term] +id: GO:1904333 +name: positive regulation of error-prone translesion synthesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of error-prone translesion synthesis." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:22761594] +synonym: "activation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "activation of error-prone translesion synthesis" NARROW [GOC:TermGenie] +synonym: "activation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "activation of mutagenic PRR" NARROW [GOC:TermGenie] +synonym: "positive regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "positive regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "positive regulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "up regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "up regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "up regulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "up-regulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "up-regulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "up-regulation of mutagenic PRR" EXACT [GOC:TermGenie] +synonym: "upregulation of error-prone postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "upregulation of error-prone translesion synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of mutagenic postreplication DNA repair" RELATED [GOC:TermGenie] +synonym: "upregulation of mutagenic PRR" EXACT [GOC:TermGenie] +is_a: GO:0045739 ! positive regulation of DNA repair +is_a: GO:1904331 ! regulation of error-prone translesion synthesis +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process +relationship: positively_regulates GO:0042276 ! error-prone translesion synthesis + +[Term] +id: GO:1904334 +name: heme import across plasma membrane +namespace: biological_process +def: "The directed movement of heme from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:25733668] +synonym: "heme assimilation" BROAD [] +is_a: GO:0035351 ! heme transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:0140420 ! heme import into cell + +[Term] +id: GO:1904335 +name: regulation of ductus arteriosus closure +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] +is_a: GO:1905651 ! regulation of artery morphogenesis +relationship: regulates GO:0097070 ! ductus arteriosus closure + +[Term] +id: GO:1904336 +name: negative regulation of ductus arteriosus closure +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] +synonym: "down regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +synonym: "down-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +synonym: "downregulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +synonym: "inhibition of ductus arteriosus closure" NARROW [GOC:TermGenie] +is_a: GO:1904335 ! regulation of ductus arteriosus closure +is_a: GO:1905652 ! negative regulation of artery morphogenesis +relationship: negatively_regulates GO:0097070 ! ductus arteriosus closure + +[Term] +id: GO:1904337 +name: positive regulation of ductus arteriosus closure +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ductus arteriosus closure." [GO_REF:0000058, GOC:TermGenie, PMID:16303610] +synonym: "activation of ductus arteriosus closure" NARROW [GOC:TermGenie] +synonym: "up regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +synonym: "up-regulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +synonym: "upregulation of ductus arteriosus closure" EXACT [GOC:TermGenie] +is_a: GO:1904335 ! regulation of ductus arteriosus closure +is_a: GO:1905653 ! positive regulation of artery morphogenesis +relationship: positively_regulates GO:0097070 ! ductus arteriosus closure + +[Term] +id: GO:1904338 +name: regulation of dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0071542 ! dopaminergic neuron differentiation + +[Term] +id: GO:1904339 +name: negative regulation of dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] +synonym: "down regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation +relationship: negatively_regulates GO:0071542 ! dopaminergic neuron differentiation + +[Term] +id: GO:1904340 +name: positive regulation of dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dopaminergic neuron differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:15522889] +synonym: "activation of dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation +relationship: positively_regulates GO:0071542 ! dopaminergic neuron differentiation + +[Term] +id: GO:1904341 +name: regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: regulates GO:1990765 ! colon smooth muscle contraction + +[Term] +id: GO:1904342 +name: negative regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +synonym: "down regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of colon smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904341 ! regulation of colon smooth muscle contraction +relationship: negatively_regulates GO:1990765 ! colon smooth muscle contraction + +[Term] +id: GO:1904343 +name: positive regulation of colon smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:24170253] +synonym: "activation of colon smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of colon smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904341 ! regulation of colon smooth muscle contraction +relationship: positively_regulates GO:1990765 ! colon smooth muscle contraction + +[Term] +id: GO:1904344 +name: regulation of gastric mucosal blood circulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] +synonym: "regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +is_a: GO:1903522 ! regulation of blood circulation +relationship: regulates GO:1990768 ! gastric mucosal blood circulation + +[Term] +id: GO:1904345 +name: negative regulation of gastric mucosal blood circulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] +synonym: "down regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "down regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "down-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "downregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "downregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "inhibition of gastric mucosal blood circulation" NARROW [GOC:TermGenie] +synonym: "inhibition of stomach mucosal blood circulation" NARROW [GOC:TermGenie] +synonym: "negative regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +is_a: GO:1903523 ! negative regulation of blood circulation +is_a: GO:1904344 ! regulation of gastric mucosal blood circulation +relationship: negatively_regulates GO:1990768 ! gastric mucosal blood circulation + +[Term] +id: GO:1904346 +name: positive regulation of gastric mucosal blood circulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation." [GO_REF:0000058, GOC:TermGenie, PMID:10807413] +synonym: "activation of gastric mucosal blood circulation" NARROW [GOC:TermGenie] +synonym: "activation of stomach mucosal blood circulation" NARROW [GOC:TermGenie] +synonym: "positive regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "up regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "up regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "up-regulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "upregulation of gastric mucosal blood circulation" EXACT [GOC:TermGenie] +synonym: "upregulation of stomach mucosal blood circulation" EXACT [GOC:TermGenie] +is_a: GO:1903524 ! positive regulation of blood circulation +is_a: GO:1904344 ! regulation of gastric mucosal blood circulation +relationship: positively_regulates GO:1990768 ! gastric mucosal blood circulation + +[Term] +id: GO:1904347 +name: regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +is_a: GO:1904304 ! regulation of gastro-intestinal system smooth muscle contraction +relationship: regulates GO:1990770 ! small intestine smooth muscle contraction + +[Term] +id: GO:1904348 +name: negative regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "down regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:1904305 ! negative regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction +relationship: negatively_regulates GO:1990770 ! small intestine smooth muscle contraction + +[Term] +id: GO:1904349 +name: positive regulation of small intestine smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "activation of small intestine smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of small intestine smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:1904306 ! positive regulation of gastro-intestinal system smooth muscle contraction +is_a: GO:1904347 ! regulation of small intestine smooth muscle contraction +relationship: positively_regulates GO:1990770 ! small intestine smooth muscle contraction + +[Term] +id: GO:1904350 +name: regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:1903362 ! regulation of cellular protein catabolic process +relationship: regulates GO:0007039 ! protein catabolic process in the vacuole + +[Term] +id: GO:1904351 +name: negative regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "down regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "down regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "down regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "down-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "downregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "downregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "downregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "inhibition of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] +synonym: "inhibition of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "inhibition of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "negative regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:1903363 ! negative regulation of cellular protein catabolic process +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +relationship: negatively_regulates GO:0007039 ! protein catabolic process in the vacuole + +[Term] +id: GO:1904352 +name: positive regulation of protein catabolic process in the vacuole +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein catabolic process in the vacuole." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25635054] +synonym: "activation of protein catabolic process in the vacuole" NARROW [GOC:TermGenie] +synonym: "activation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "activation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "positive regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "up regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "up regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "up regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "up-regulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +synonym: "upregulation of protein catabolic process in the vacuole" EXACT [GOC:TermGenie] +synonym: "upregulation of vacuolar protein breakdown" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein catabolic process" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein catabolism" RELATED [GOC:TermGenie] +synonym: "upregulation of vacuolar protein degradation" RELATED [GOC:TermGenie] +is_a: GO:1903364 ! positive regulation of cellular protein catabolic process +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +relationship: positively_regulates GO:0007039 ! protein catabolic process in the vacuole + +[Term] +id: GO:1904353 +name: regulation of telomere capping +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +synonym: "regulation of telomere end protection" EXACT [GOC:TermGenie] +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0016233 ! telomere capping + +[Term] +id: GO:1904354 +name: negative regulation of telomere capping +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +synonym: "down regulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "down regulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "inhibition of telomere capping" NARROW [GOC:TermGenie] +synonym: "inhibition of telomere end protection" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomere end protection" EXACT [GOC:TermGenie] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:1904353 ! regulation of telomere capping +relationship: negatively_regulates GO:0016233 ! telomere capping + +[Term] +id: GO:1904355 +name: positive regulation of telomere capping +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomere capping." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +synonym: "activation of telomere capping" NARROW [GOC:TermGenie] +synonym: "activation of telomere end protection" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "up regulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "up regulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomere end protection" EXACT [GOC:TermGenie] +synonym: "upregulation of telomere capping" EXACT [GOC:TermGenie] +synonym: "upregulation of telomere end protection" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:1904353 ! regulation of telomere capping +relationship: positively_regulates GO:0016233 ! telomere capping + +[Term] +id: GO:1904356 +name: regulation of telomere maintenance via telomere lengthening +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0010833 ! telomere maintenance via telomere lengthening + +[Term] +id: GO:1904357 +name: negative regulation of telomere maintenance via telomere lengthening +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +synonym: "down regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +synonym: "inhibition of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening +relationship: negatively_regulates GO:0010833 ! telomere maintenance via telomere lengthening + +[Term] +id: GO:1904358 +name: positive regulation of telomere maintenance via telomere lengthening +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance via telomere lengthening." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892] +synonym: "activation of telomere maintenance via telomere lengthening" NARROW [GOC:TermGenie] +synonym: "up regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +synonym: "upregulation of telomere maintenance via telomere lengthening" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening +relationship: positively_regulates GO:0010833 ! telomere maintenance via telomere lengthening + +[Term] +id: GO:1904359 +name: regulation of spore germination +namespace: biological_process +alt_id: GO:0075006 +def: "Any process that modulates the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] +synonym: "modulation of spore germination on or near host" NARROW [] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0009847 ! spore germination + +[Term] +id: GO:1904360 +name: negative regulation of spore germination +namespace: biological_process +alt_id: GO:0075008 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] +synonym: "down regulation of spore germination" EXACT [GOC:TermGenie] +synonym: "down-regulation of spore germination" EXACT [GOC:TermGenie] +synonym: "downregulation of spore germination" EXACT [GOC:TermGenie] +synonym: "inhibition of spore germination" NARROW [GOC:TermGenie] +synonym: "negative regulation of spore germination on or near host" NARROW [] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1904359 ! regulation of spore germination +relationship: negatively_regulates GO:0009847 ! spore germination + +[Term] +id: GO:1904361 +name: positive regulation of spore germination +namespace: biological_process +alt_id: GO:0075007 +def: "Any process that activates or increases the frequency, rate or extent of spore germination." [GO_REF:0000058, GOC:TermGenie, PMID:14718564, PMID:8798577] +synonym: "activation of spore germination" NARROW [GOC:TermGenie] +synonym: "positive regulation of spore germination on or near host" NARROW [] +synonym: "up regulation of spore germination" EXACT [GOC:TermGenie] +synonym: "up-regulation of spore germination" EXACT [GOC:TermGenie] +synonym: "upregulation of spore germination" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1904359 ! regulation of spore germination +relationship: positively_regulates GO:0009847 ! spore germination + +[Term] +id: GO:1904362 +name: regulation of calcitonin secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0036161 ! calcitonin secretion + +[Term] +id: GO:1904363 +name: negative regulation of calcitonin secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +synonym: "down regulation of calcitonin secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcitonin secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of calcitonin secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of calcitonin secretion" NARROW [GOC:TermGenie] +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +is_a: GO:1904362 ! regulation of calcitonin secretion +relationship: negatively_regulates GO:0036161 ! calcitonin secretion + +[Term] +id: GO:1904364 +name: positive regulation of calcitonin secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcitonin secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +synonym: "activation of calcitonin secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of calcitonin secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcitonin secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of calcitonin secretion" EXACT [GOC:TermGenie] +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +is_a: GO:1904362 ! regulation of calcitonin secretion +relationship: positively_regulates GO:0036161 ! calcitonin secretion + +[Term] +id: GO:1904365 +name: regulation of chemokinesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0042466 ! chemokinesis + +[Term] +id: GO:1904366 +name: negative regulation of chemokinesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +synonym: "down regulation of chemokinesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemokinesis" EXACT [GOC:TermGenie] +synonym: "downregulation of chemokinesis" EXACT [GOC:TermGenie] +synonym: "inhibition of chemokinesis" NARROW [GOC:TermGenie] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1904365 ! regulation of chemokinesis +relationship: negatively_regulates GO:0042466 ! chemokinesis + +[Term] +id: GO:1904367 +name: positive regulation of chemokinesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemokinesis." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +synonym: "activation of chemokinesis" NARROW [GOC:TermGenie] +synonym: "up regulation of chemokinesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of chemokinesis" EXACT [GOC:TermGenie] +synonym: "upregulation of chemokinesis" EXACT [GOC:TermGenie] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1904365 ! regulation of chemokinesis +relationship: positively_regulates GO:0042466 ! chemokinesis + +[Term] +id: GO:1904368 +name: regulation of sclerenchyma cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0014001 ! sclerenchyma cell differentiation + +[Term] +id: GO:1904369 +name: positive regulation of sclerenchyma cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sclerenchyma cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:26025534] +synonym: "up regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of sclerenchyma cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1904368 ! regulation of sclerenchyma cell differentiation +relationship: positively_regulates GO:0014001 ! sclerenchyma cell differentiation + +[Term] +id: GO:1904370 +name: regulation of protein localization to actin cortical patch +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +synonym: "regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +is_a: GO:1904776 ! regulation of protein localization to cell cortex +relationship: regulates GO:0044379 ! protein localization to actin cortical patch + +[Term] +id: GO:1904371 +name: negative regulation of protein localization to actin cortical patch +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +synonym: "down regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to actin cortical patch" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to actin cortical patch" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +is_a: GO:1904370 ! regulation of protein localization to actin cortical patch +is_a: GO:1904777 ! negative regulation of protein localization to cell cortex +relationship: negatively_regulates GO:0044379 ! protein localization to actin cortical patch + +[Term] +id: GO:1904372 +name: positive regulation of protein localization to actin cortical patch +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to actin cortical patch." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +synonym: "activation of protein localisation to actin cortical patch" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to actin cortical patch" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to actin cortical patch" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to actin cortical patch" EXACT [GOC:TermGenie] +is_a: GO:1904370 ! regulation of protein localization to actin cortical patch +is_a: GO:1904778 ! positive regulation of protein localization to cell cortex +relationship: positively_regulates GO:0044379 ! protein localization to actin cortical patch + +[Term] +id: GO:1904373 +name: response to kainic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1904374 +name: cellular response to kainic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a kainic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17443789] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904373 ! response to kainic acid + +[Term] +id: GO:1904375 +name: regulation of protein localization to cell periphery +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1904376 +name: negative regulation of protein localization to cell periphery +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +synonym: "down regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localization to cell periphery" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1904375 ! regulation of protein localization to cell periphery +relationship: negatively_regulates GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1904377 +name: positive regulation of protein localization to cell periphery +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery." [GO_REF:0000058, GOC:TermGenie, PMID:18216290] +synonym: "activation of protein localization to cell periphery" NARROW [GOC:TermGenie] +synonym: "up regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cell periphery" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1904375 ! regulation of protein localization to cell periphery +relationship: positively_regulates GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1904378 +name: maintenance of unfolded protein involved in ERAD pathway +namespace: biological_process +def: "Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303] +synonym: "chaperone holdase activity" RELATED [PMID:23417671] +synonym: "ERAD chaperone-like activity" RELATED [GOC:bf] +synonym: "holdase activity" RELATED [PMID:21636303] +synonym: "maintenance of unfolded protein during ERAD" RELATED [GOC:bf] +synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "maintenance of unfolded protein involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] +is_a: GO:0036506 ! maintenance of unfolded protein +relationship: part_of GO:0036503 ! ERAD pathway + +[Term] +id: GO:1904379 +name: protein localization to cytosolic proteasome complex involved in ERAD pathway +namespace: biological_process +def: "Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation." [GO_REF:0000060, GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, GOC:TermGenie, PMID:21636303] +synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localisation in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] +synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localisation to cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] +synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localization in cytosolic proteasome complex involved in ERAD pathway" EXACT [GOC:TermGenie] +synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation" EXACT [GOC:TermGenie] +synonym: "protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:TermGenie] +synonym: "protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway" RELATED [GOC:TermGenie] +is_a: GO:1904327 ! protein localization to cytosolic proteasome complex +relationship: part_of GO:0036503 ! ERAD pathway + +[Term] +id: GO:1904380 +name: endoplasmic reticulum mannose trimming +namespace: biological_process +def: "Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC)." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966] +synonym: "ER mannose trimming" EXACT [GOC:bf] +synonym: "ER protein alpha-1,2-demannosylation" EXACT [GOC:bf] +synonym: "glycoprotein mannose trimming in endoplasmic reticulum quality control compartment" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming in ER quality control compartment" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming in ER-derived quality control compartment" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming in ERQC" RELATED [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation in ER" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation in ER quality control compartment" EXACT [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation in ER-derived quality control compartment" RELATED [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation in ERQC" EXACT [GOC:TermGenie] +is_a: GO:0036508 ! protein alpha-1,2-demannosylation + +[Term] +id: GO:1904381 +name: Golgi apparatus mannose trimming +namespace: biological_process +def: "Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:10915796] +synonym: "glycoprotein mannose trimming in Golgi apparatus" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming in Golgi complex" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming in Golgi ribbon" RELATED [GOC:TermGenie] +synonym: "mannose trimming in cis-Golgi" NARROW [GOC:bf] +synonym: "mannose trimming in Golgi" BROAD [GOC:TermGenie] +synonym: "mannose trimming in Golgi apparatus" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation in Golgi apparatus" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation in Golgi complex" EXACT [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation in Golgi ribbon" NARROW [GOC:TermGenie] +is_a: GO:0006491 ! N-glycan processing +is_a: GO:0036508 ! protein alpha-1,2-demannosylation + +[Term] +id: GO:1904382 +name: mannose trimming involved in glycoprotein ERAD pathway +namespace: biological_process +def: "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD)." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24519966] +synonym: "glycoprotein mannose trimming involved in ER-associated glycoprotein degradation" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming involved in glycoprotein ERAD pathway" RELATED [GOC:TermGenie] +synonym: "glycoprotein mannose trimming involved in gpERAD" RELATED [GOC:TermGenie] +synonym: "mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation" EXACT [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD" EXACT [GOC:TermGenie] +synonym: "protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway" EXACT [GOC:bf] +synonym: "protein alpha-1,2-demannosylation involved in gpERAD" EXACT [GOC:TermGenie] +is_a: GO:0035977 ! protein deglycosylation involved in glycoprotein catabolic process +is_a: GO:0036508 ! protein alpha-1,2-demannosylation +relationship: part_of GO:0097466 ! ubiquitin-dependent glycoprotein ERAD pathway + +[Term] +id: GO:1904383 +name: response to sodium phosphate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659] +is_a: GO:0010035 ! response to inorganic substance +is_a: GO:1902074 ! response to salt + +[Term] +id: GO:1904384 +name: cellular response to sodium phosphate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24625659] +is_a: GO:1902075 ! cellular response to salt +is_a: GO:1904383 ! response to sodium phosphate + +[Term] +id: GO:1904385 +name: cellular response to angiotensin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [GO_REF:0000071, GOC:TermGenie, PMID:22982863] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1990776 ! response to angiotensin + +[Term] +id: GO:1904386 +name: response to L-phenylalanine derivative +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1904387 +name: cellular response to L-phenylalanine derivative +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12112407] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904386 ! response to L-phenylalanine derivative + +[Term] +id: GO:1904388 +name: negative regulation of ncRNA transcription associated with protein coding gene TSS/TES +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ncRNA transcription associated with protein coding gene TSS/TES." [GO_REF:0000058, GOC:TermGenie, PMID:20502517] +synonym: "down regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] +synonym: "down regulation of pasRNA transcription" NARROW [GOC:TermGenie] +synonym: "down-regulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] +synonym: "down-regulation of pasRNA transcription" NARROW [GOC:TermGenie] +synonym: "downregulation of ncRNA transcription associated with protein coding gene TSS/TES" EXACT [GOC:TermGenie] +synonym: "downregulation of pasRNA transcription" NARROW [GOC:TermGenie] +synonym: "inhibition of ncRNA transcription associated with protein coding gene TSS/TES" NARROW [GOC:TermGenie] +synonym: "inhibition of pasRNA transcription" NARROW [GOC:TermGenie] +synonym: "negative regulation of pasRNA transcription" NARROW [GOC:TermGenie] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: negatively_regulates GO:0098790 ! ncRNA transcription associated with protein coding gene TSS/TES + +[Term] +id: GO:1904389 +name: rod bipolar cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a rod bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:16914133] +is_a: GO:0060040 ! retinal bipolar neuron differentiation + +[Term] +id: GO:1904390 +name: cone retinal bipolar cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a cone retinal bipolar cell." [GO_REF:0000086, GOC:TermGenie, PMID:24123365] +synonym: "cone bipolar cell differentiation" EXACT [PMID:14745032] +synonym: "retinal cone bipolar cell differentiation" EXACT [] +is_a: GO:0060040 ! retinal bipolar neuron differentiation + +[Term] +id: GO:1904391 +name: response to ciliary neurotrophic factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1904392 +name: cellular response to ciliary neurotrophic factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16914133] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904391 ! response to ciliary neurotrophic factor + +[Term] +id: GO:1904393 +name: regulation of skeletal muscle acetylcholine-gated channel clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1903909 ! regulation of receptor clustering +relationship: regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering + +[Term] +id: GO:1904394 +name: negative regulation of skeletal muscle acetylcholine-gated channel clustering +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "down regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "down regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "down regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "inhibition of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie] +synonym: "inhibition of skeletal muscle AChR clustering" NARROW [GOC:TermGenie] +synonym: "inhibition of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie] +synonym: "negative regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "negative regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1903910 ! negative regulation of receptor clustering +is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering +relationship: negatively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering + +[Term] +id: GO:1904395 +name: positive regulation of skeletal muscle acetylcholine-gated channel clustering +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "activation of skeletal muscle acetylcholine-gated channel clustering" NARROW [GOC:TermGenie] +synonym: "activation of skeletal muscle AChR clustering" NARROW [GOC:TermGenie] +synonym: "activation of skeletal muscle nicotinic acetylcholine receptor clustering" NARROW [GOC:TermGenie] +synonym: "positive regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "positive regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal muscle acetylcholine-gated channel clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal muscle AChR clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of skeletal muscle nicotinic acetylcholine receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1903911 ! positive regulation of receptor clustering +is_a: GO:1904393 ! regulation of skeletal muscle acetylcholine-gated channel clustering +relationship: positively_regulates GO:0071340 ! skeletal muscle acetylcholine-gated channel clustering + +[Term] +id: GO:1904396 +name: regulation of neuromuscular junction development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "regulation of NMJ stability" RELATED [GOC:TermGenie] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:1904397 +name: negative regulation of neuromuscular junction development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "down regulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "down regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "down regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "down regulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "down-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "down-regulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "downregulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "downregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "downregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "downregulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "inhibition of neuromuscular junction development" NARROW [GOC:TermGenie] +synonym: "inhibition of neuromuscular junction organization" NARROW [GOC:TermGenie] +synonym: "inhibition of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "inhibition of NMJ stability" RELATED [GOC:TermGenie] +synonym: "negative regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "negative regulation of NMJ stability" RELATED [GOC:TermGenie] +is_a: GO:1904396 ! regulation of neuromuscular junction development +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:1904398 +name: positive regulation of neuromuscular junction development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuromuscular junction development." [GO_REF:0000058, GOC:TermGenie, PMID:7722643] +synonym: "activation of neuromuscular junction development" NARROW [GOC:TermGenie] +synonym: "activation of neuromuscular junction organization" NARROW [GOC:TermGenie] +synonym: "activation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "activation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "positive regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "positive regulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "up regulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "up regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "up regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "up regulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "up-regulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "up-regulation of NMJ stability" RELATED [GOC:TermGenie] +synonym: "upregulation of neuromuscular junction development" EXACT [GOC:TermGenie] +synonym: "upregulation of neuromuscular junction organization" EXACT [GOC:TermGenie] +synonym: "upregulation of neuromuscular junction stability" RELATED [GOC:TermGenie] +synonym: "upregulation of NMJ stability" RELATED [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1904396 ! regulation of neuromuscular junction development +relationship: positively_regulates GO:0007528 ! neuromuscular junction development + +[Term] +id: GO:1904399 +name: heparan sulfate binding +namespace: molecular_function +def: "Binding to heparan sulfate." [GO_REF:0000067, GOC:TermGenie, PMID:8567685] +is_a: GO:0005539 ! glycosaminoglycan binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:1904400 +name: response to Thyroid stimulating hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928] +is_a: GO:1904587 ! response to glycoprotein + +[Term] +id: GO:1904401 +name: cellular response to Thyroid stimulating hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Thyroid stimulating hormone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11238928] +is_a: GO:1904400 ! response to Thyroid stimulating hormone +is_a: GO:1904588 ! cellular response to glycoprotein + +[Term] +id: GO:1904402 +name: response to nocodazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904403 +name: cellular response to nocodazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nocodazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17822405] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904402 ! response to nocodazole + +[Term] +id: GO:1904404 +name: response to formaldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904405 +name: cellular response to formaldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a formaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:9149109] +is_a: GO:0110096 ! cellular response to aldehyde +is_a: GO:1904404 ! response to formaldehyde + +[Term] +id: GO:1904406 +name: negative regulation of nitric oxide metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "down regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of nitric oxide metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of nitric oxide metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0080164 ! regulation of nitric oxide metabolic process +relationship: negatively_regulates GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:1904407 +name: positive regulation of nitric oxide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nitric oxide metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:11991626] +synonym: "activation of nitric oxide metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of nitric oxide metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of nitric oxide metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of nitric oxide metabolism" EXACT [GOC:TermGenie] +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0080164 ! regulation of nitric oxide metabolic process +relationship: positively_regulates GO:0046209 ! nitric oxide metabolic process + +[Term] +id: GO:1904408 +name: melatonin binding +namespace: molecular_function +def: "Binding to melatonin." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10379923] +is_a: GO:0033218 ! amide binding +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding + +[Term] +id: GO:1904409 +name: regulation of secretory granule organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] +synonym: "regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0033363 ! secretory granule organization + +[Term] +id: GO:1904410 +name: negative regulation of secretory granule organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] +synonym: "down regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "down regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "downregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of secretory granule organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of secretory granule organization" NARROW [GOC:TermGenie] +synonym: "inhibition of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1904409 ! regulation of secretory granule organization +relationship: negatively_regulates GO:0033363 ! secretory granule organization + +[Term] +id: GO:1904411 +name: positive regulation of secretory granule organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secretory granule organization." [GO_REF:0000058, GOC:TermGenie, PMID:15039777] +synonym: "activation of secretory granule organisation" NARROW [GOC:TermGenie] +synonym: "activation of secretory granule organization" NARROW [GOC:TermGenie] +synonym: "activation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "up regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of secretory granule organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of secretory granule organization" EXACT [GOC:TermGenie] +synonym: "upregulation of secretory granule organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1904409 ! regulation of secretory granule organization +relationship: positively_regulates GO:0033363 ! secretory granule organization + +[Term] +id: GO:1904412 +name: regulation of cardiac ventricle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0003231 ! cardiac ventricle development + +[Term] +id: GO:1904413 +name: negative regulation of cardiac ventricle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] +synonym: "down regulation of cardiac ventricle development" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac ventricle development" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac ventricle development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904412 ! regulation of cardiac ventricle development +relationship: negatively_regulates GO:0003231 ! cardiac ventricle development + +[Term] +id: GO:1904414 +name: positive regulation of cardiac ventricle development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle development." [GO_REF:0000058, GOC:TermGenie, PMID:19590510] +synonym: "activation of cardiac ventricle development" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac ventricle development" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac ventricle development" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac ventricle development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904412 ! regulation of cardiac ventricle development +relationship: positively_regulates GO:0003231 ! cardiac ventricle development + +[Term] +id: GO:1904415 +name: regulation of xenophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] +comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0016241 ! regulation of macroautophagy +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0098792 ! xenophagy + +[Term] +id: GO:1904416 +name: negative regulation of xenophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] +comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). +synonym: "down regulation of xenophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of xenophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of xenophagy" EXACT [GOC:TermGenie] +synonym: "inhibition of xenophagy" NARROW [GOC:TermGenie] +is_a: GO:0002832 ! negative regulation of response to biotic stimulus +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1904415 ! regulation of xenophagy +relationship: negatively_regulates GO:0098792 ! xenophagy + +[Term] +id: GO:1904417 +name: positive regulation of xenophagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xenophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21617041] +comment: An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). +synonym: "activation of xenophagy" NARROW [GOC:TermGenie] +synonym: "up regulation of xenophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of xenophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of xenophagy" EXACT [GOC:TermGenie] +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1904415 ! regulation of xenophagy +relationship: positively_regulates GO:0098792 ! xenophagy + +[Term] +id: GO:1904418 +name: regulation of telomeric loop formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of t-loop formation" EXACT [GOC:TermGenie] +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0031627 ! telomeric loop formation + +[Term] +id: GO:1904419 +name: negative regulation of telomeric loop formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "down regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric loop formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric loop formation" EXACT [GOC:TermGenie] +synonym: "downregulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric loop formation" EXACT [GOC:TermGenie] +synonym: "inhibition of t-loop biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of t-loop formation" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric loop formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of t-loop formation" EXACT [GOC:TermGenie] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:1904418 ! regulation of telomeric loop formation +relationship: negatively_regulates GO:0031627 ! telomeric loop formation + +[Term] +id: GO:1904420 +name: positive regulation of telomeric loop formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomeric loop formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "activation of t-loop biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of t-loop formation" NARROW [GOC:TermGenie] +synonym: "activation of telomeric loop formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "up regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric loop formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric loop formation" EXACT [GOC:TermGenie] +synonym: "upregulation of t-loop biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of t-loop formation" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric loop formation" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:1904418 ! regulation of telomeric loop formation +relationship: positively_regulates GO:0031627 ! telomeric loop formation + +[Term] +id: GO:1904421 +name: response to D-galactosamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904422 +name: cellular response to D-galactosamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactosamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12057922] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904421 ! response to D-galactosamine + +[Term] +id: GO:1904423 +name: dehydrodolichyl diphosphate synthase complex +namespace: cellular_component +def: "A protein complex which is capable of dehydrodolichyl diphosphate synthase activity." [GO_REF:0000088, GOC:TermGenie, PMID:25066056] +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1904424 +name: regulation of GTP binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1904425 +name: negative regulation of GTP binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] +synonym: "down regulation of GTP binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of GTP binding" EXACT [GOC:TermGenie] +synonym: "downregulation of GTP binding" EXACT [GOC:TermGenie] +synonym: "inhibition of GTP binding" NARROW [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1904424 ! regulation of GTP binding + +[Term] +id: GO:1904426 +name: positive regulation of GTP binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of GTP binding." [GO_REF:0000059, GOC:TermGenie, PMID:19066305, PMID:21454546] +synonym: "activation of GTP binding" NARROW [GOC:TermGenie] +synonym: "up regulation of GTP binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of GTP binding" EXACT [GOC:TermGenie] +synonym: "upregulation of GTP binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1904424 ! regulation of GTP binding + +[Term] +id: GO:1904427 +name: positive regulation of calcium ion transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport." [GO_REF:0000058, GOC:TermGenie, PMID:22910094] +synonym: "activation of calcium ion membrane transport" NARROW [GOC:TermGenie] +synonym: "activation of calcium ion transmembrane transport" NARROW [GOC:TermGenie] +synonym: "activation of transmembrane calcium transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "positive regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion membrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion transmembrane transport" EXACT [GOC:TermGenie] +synonym: "upregulation of transmembrane calcium transport" EXACT [GOC:TermGenie] +is_a: GO:0051928 ! positive regulation of calcium ion transport +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +relationship: positively_regulates GO:0070588 ! calcium ion transmembrane transport + +[Term] +id: GO:1904428 +name: negative regulation of tubulin deacetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylation." [GO_REF:0000058, GOC:TermGenie, PMID:23886946] +synonym: "down regulation of tubulin deacetylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of tubulin deacetylation" EXACT [GOC:TermGenie] +synonym: "downregulation of tubulin deacetylation" EXACT [GOC:TermGenie] +synonym: "inhibition of tubulin deacetylation" NARROW [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:0090043 ! regulation of tubulin deacetylation +relationship: negatively_regulates GO:0090042 ! tubulin deacetylation + +[Term] +id: GO:1904429 +name: regulation of t-circle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "regulation of telomeric circle formation" EXACT [GOC:TermGenie] +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0090656 ! t-circle formation + +[Term] +id: GO:1904430 +name: negative regulation of t-circle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "down regulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "inhibition of t-circle formation" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric circle formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomeric circle formation" EXACT [GOC:TermGenie] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1904429 ! regulation of t-circle formation +relationship: negatively_regulates GO:0090656 ! t-circle formation + +[Term] +id: GO:1904431 +name: positive regulation of t-circle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of t-circle formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "activation of t-circle formation" NARROW [GOC:TermGenie] +synonym: "activation of telomeric circle formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric circle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of t-circle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric circle formation" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:1904429 ! regulation of t-circle formation +relationship: positively_regulates GO:0090656 ! t-circle formation + +[Term] +id: GO:1904432 +name: regulation of ferrous iron binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1904433 +name: negative regulation of ferrous iron binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "down regulation of ferrous iron binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrous iron binding" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrous iron binding" EXACT [GOC:TermGenie] +synonym: "inhibition of ferrous iron binding" NARROW [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1904432 ! regulation of ferrous iron binding + +[Term] +id: GO:1904434 +name: positive regulation of ferrous iron binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ferrous iron binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "activation of ferrous iron binding" NARROW [GOC:TermGenie] +synonym: "up regulation of ferrous iron binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrous iron binding" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrous iron binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1904432 ! regulation of ferrous iron binding + +[Term] +id: GO:1904435 +name: regulation of transferrin receptor binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1904436 +name: negative regulation of transferrin receptor binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "down regulation of transferrin receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of transferrin receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of transferrin receptor binding" EXACT [GOC:TermGenie] +synonym: "inhibition of transferrin receptor binding" NARROW [GOC:TermGenie] +is_a: GO:1900121 ! negative regulation of receptor binding +is_a: GO:1904435 ! regulation of transferrin receptor binding + +[Term] +id: GO:1904437 +name: positive regulation of transferrin receptor binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transferrin receptor binding." [GO_REF:0000059, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "activation of transferrin receptor binding" NARROW [GOC:TermGenie] +synonym: "up regulation of transferrin receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of transferrin receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of transferrin receptor binding" EXACT [GOC:TermGenie] +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:1904435 ! regulation of transferrin receptor binding + +[Term] +id: GO:1904438 +name: regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903989 +def: "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "regulation of ferrous iron import into cell" RELATED [] +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:0060341 ! regulation of cellular localization +is_a: GO:0065008 ! regulation of biological quality +relationship: regulates GO:0098711 ! iron ion import across plasma membrane + +[Term] +id: GO:1904439 +name: negative regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903990 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "down regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "down regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "down-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "down-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "downregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "downregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "negative regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "negative regulation of ferrous iron import into cell" RELATED [] +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904438 ! regulation of iron ion import across plasma membrane +relationship: negatively_regulates GO:0098711 ! iron ion import across plasma membrane + +[Term] +id: GO:1904440 +name: positive regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903991 +def: "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie] +synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "positive regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "positive regulation of ferrous iron import into cell" RELATED [] +synonym: "up regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "up regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "up-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "up-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "upregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "upregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904438 ! regulation of iron ion import across plasma membrane +relationship: positively_regulates GO:0098711 ! iron ion import across plasma membrane + +[Term] +id: GO:1904441 +name: regulation of thyroid gland epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] +synonym: "regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:1990789 ! thyroid gland epithelial cell proliferation + +[Term] +id: GO:1904442 +name: negative regulation of thyroid gland epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] +synonym: "down regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "down regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "down regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "down-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "down-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "downregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "downregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation +relationship: negatively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation + +[Term] +id: GO:1904443 +name: positive regulation of thyroid gland epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:17646383] +synonym: "activation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of thyroid gland epithelial cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "up-regulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "up-regulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of Hurthle cell proliferation" NARROW [GOC:TermGenie] +synonym: "upregulation of thyroid follicular cell proliferation" NARROW [GOC:TermGenie] +synonym: "upregulation of thyroid gland epithelial cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904441 ! regulation of thyroid gland epithelial cell proliferation +relationship: positively_regulates GO:1990789 ! thyroid gland epithelial cell proliferation + +[Term] +id: GO:1904444 +name: regulation of establishment of Sertoli cell barrier +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] +synonym: "regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of SCB" EXACT [GOC:TermGenie] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0097368 ! establishment of Sertoli cell barrier + +[Term] +id: GO:1904445 +name: negative regulation of establishment of Sertoli cell barrier +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] +synonym: "down regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of blood-testis barrier" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of BTB" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of SCB" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of SCB" EXACT [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0097368 ! establishment of Sertoli cell barrier + +[Term] +id: GO:1904446 +name: positive regulation of establishment of Sertoli cell barrier +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of Sertoli cell barrier." [GO_REF:0000058, GOC:TermGenie, PMID:18057314] +synonym: "activation of establishment of blood-testis barrier" NARROW [GOC:TermGenie] +synonym: "activation of establishment of BTB" NARROW [GOC:TermGenie] +synonym: "activation of establishment of SCB" NARROW [GOC:TermGenie] +synonym: "activation of establishment of Sertoli cell barrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of blood-testis barrier" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of BTB" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of SCB" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of Sertoli cell barrier" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:1904444 ! regulation of establishment of Sertoli cell barrier +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0097368 ! establishment of Sertoli cell barrier + +[Term] +id: GO:1904447 +name: folate import across plasma membrane +namespace: biological_process +def: "The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:19762432] +synonym: "folate import into cell" EXACT [GOC:hal] +synonym: "folic acid import across plasma membrane" RELATED [] +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:0098838 ! folate transmembrane transport + +[Term] +id: GO:1904448 +name: regulation of aspartate secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051955 ! regulation of amino acid transport +is_a: GO:1903530 ! regulation of secretion by cell +relationship: regulates GO:0061528 ! aspartate secretion + +[Term] +id: GO:1904449 +name: negative regulation of aspartate secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] +synonym: "down regulation of aspartate secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartate secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartate secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of aspartate secretion" NARROW [GOC:TermGenie] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903531 ! negative regulation of secretion by cell +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:1904448 ! regulation of aspartate secretion +relationship: negatively_regulates GO:0061528 ! aspartate secretion + +[Term] +id: GO:1904450 +name: positive regulation of aspartate secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aspartate secretion." [GO_REF:0000058, GOC:TermGenie, PMID:2342602] +synonym: "activation of aspartate secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of aspartate secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartate secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartate secretion" EXACT [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903532 ! positive regulation of secretion by cell +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:1904448 ! regulation of aspartate secretion +relationship: positively_regulates GO:0061528 ! aspartate secretion + +[Term] +id: GO:1904451 +name: regulation of potassium:proton exchanging ATPase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] +synonym: "regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] +synonym: "regulation of proton pump activity" BROAD [GOC:TermGenie] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0043462 ! regulation of ATP-dependent activity +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity + +[Term] +id: GO:1904452 +name: negative regulation of potassium:proton exchanging ATPase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] +synonym: "down regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "down regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "down regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "down-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "down-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "downregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "downregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie] +synonym: "inhibition of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "inhibition of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of H+-K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of H+/K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of H,K-ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "negative regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "negative regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:1901017 ! negative regulation of potassium ion transmembrane transporter activity +is_a: GO:1904451 ! regulation of potassium:proton exchanging ATPase activity + +[Term] +id: GO:1904453 +name: positive regulation of potassium:proton exchanging ATPase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity." [GO_REF:0000059, GOC:TermGenie, PMID:11897793] +synonym: "activation of (K+ + H+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP phosphohydrolase (H+/K+-exchanging)" NARROW [GOC:TermGenie] +synonym: "activation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "activation of H(+)/K(+)-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of H(+)/K(+)-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of H+-K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of H+/K+-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of H+/K+-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of H,K-ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen/potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen:potassium exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen:potassium-exchanging ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "positive regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "positive regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [] +synonym: "up regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "up regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "up regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "up-regulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "up-regulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of (K+ + H+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP phosphohydrolase (H+/K+-exchanging)" EXACT [GOC:TermGenie] +synonym: "upregulation of gastric H(+)/K(+) ATPase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of gastric H+/K+ ATPase" NARROW [GOC:TermGenie] +synonym: "upregulation of H(+)/K(+)-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of H(+)/K(+)-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of H+-K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of H+/K+-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of H+/K+-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of H,K-ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen/potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen:potassium exchanging ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen:potassium-exchanging ATPase activity" EXACT [GOC:TermGenie] +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:1901018 ! positive regulation of potassium ion transmembrane transporter activity +is_a: GO:1904451 ! regulation of potassium:proton exchanging ATPase activity + +[Term] +id: GO:1904456 +name: negative regulation of neuronal action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] +synonym: "down regulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "down regulation of neuronal action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "down-regulation of neuronal action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "downregulation of neuronal action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of generation of action potential" RELATED [GOC:TermGenie] +synonym: "inhibition of neuronal action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of generation of action potential" RELATED [GOC:TermGenie] +is_a: GO:0045759 ! negative regulation of action potential +is_a: GO:0051970 ! negative regulation of transmission of nerve impulse +is_a: GO:0098908 ! regulation of neuronal action potential +relationship: negatively_regulates GO:0019228 ! neuronal action potential + +[Term] +id: GO:1904457 +name: positive regulation of neuronal action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuronal action potential." [GO_REF:0000058, GOC:TermGenie, PMID:25126967] +synonym: "activation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "activation of neuronal action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "up regulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "up regulation of neuronal action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "up-regulation of neuronal action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of generation of action potential" RELATED [GOC:TermGenie] +synonym: "upregulation of neuronal action potential" EXACT [GOC:TermGenie] +is_a: GO:0045760 ! positive regulation of action potential +is_a: GO:0051971 ! positive regulation of transmission of nerve impulse +is_a: GO:0098908 ! regulation of neuronal action potential +relationship: positively_regulates GO:0019228 ! neuronal action potential + +[Term] +id: GO:1904458 +name: regulation of substance P secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:1990772 ! substance P secretion + +[Term] +id: GO:1904459 +name: negative regulation of substance P secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +synonym: "down regulation of substance P secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of substance P secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of substance P secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of substance P secretion" NARROW [GOC:TermGenie] +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +is_a: GO:1904458 ! regulation of substance P secretion +relationship: negatively_regulates GO:1990772 ! substance P secretion + +[Term] +id: GO:1904460 +name: positive regulation of substance P secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of substance P secretion." [GO_REF:0000058, GOC:TermGenie, PMID:11278900] +synonym: "activation of substance P secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of substance P secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of substance P secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of substance P secretion" EXACT [GOC:TermGenie] +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +is_a: GO:1904458 ! regulation of substance P secretion +relationship: positively_regulates GO:1990772 ! substance P secretion + +[Term] +id: GO:1904461 +name: ergosteryl 3-beta-D-glucoside metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] +synonym: "ergosteryl 3-beta-D-glucoside metabolism" EXACT [GOC:TermGenie] +is_a: GO:0008202 ! steroid metabolic process +is_a: GO:0016134 ! saponin metabolic process +is_a: GO:1901804 ! beta-glucoside metabolic process + +[Term] +id: GO:1904462 +name: ergosteryl 3-beta-D-glucoside catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] +synonym: "ergosteryl 3-beta-D-glucoside breakdown" EXACT [GOC:TermGenie] +synonym: "ergosteryl 3-beta-D-glucoside catabolism" EXACT [GOC:TermGenie] +synonym: "ergosteryl 3-beta-D-glucoside degradation" EXACT [GOC:TermGenie] +is_a: GO:0006706 ! steroid catabolic process +is_a: GO:0016136 ! saponin catabolic process +is_a: GO:1901805 ! beta-glucoside catabolic process +is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process + +[Term] +id: GO:1904463 +name: ergosteryl 3-beta-D-glucoside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ergosteryl 3-beta-D-glucoside." [GO_REF:0000068, GOC:TermGenie, PMID:26116408] +synonym: "ergosteryl 3-beta-D-glucoside anabolism" EXACT [GOC:TermGenie] +synonym: "ergosteryl 3-beta-D-glucoside biosynthesis" EXACT [GOC:TermGenie] +synonym: "ergosteryl 3-beta-D-glucoside formation" EXACT [GOC:TermGenie] +synonym: "ergosteryl 3-beta-D-glucoside synthesis" EXACT [GOC:TermGenie] +is_a: GO:0006694 ! steroid biosynthetic process +is_a: GO:0016135 ! saponin biosynthetic process +is_a: GO:1901806 ! beta-glucoside biosynthetic process +is_a: GO:1904461 ! ergosteryl 3-beta-D-glucoside metabolic process + +[Term] +id: GO:1904464 +name: regulation of matrix metallopeptidase secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +synonym: "regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "regulation of MMP secretion" EXACT [GOC:TermGenie] +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:1990773 ! matrix metallopeptidase secretion + +[Term] +id: GO:1904465 +name: negative regulation of matrix metallopeptidase secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +synonym: "down regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "inhibition of matrix metallopeptidase secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of MMP secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of MMP secretion" EXACT [GOC:TermGenie] +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion +relationship: negatively_regulates GO:1990773 ! matrix metallopeptidase secretion + +[Term] +id: GO:1904466 +name: positive regulation of matrix metallopeptidase secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of matrix metallopeptidase secretion." [GO_REF:0000058, GOC:TermGenie, PMID:8679543] +synonym: "activation of matrix metallopeptidase secretion" NARROW [GOC:TermGenie] +synonym: "activation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "activation of MMP secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of MMP secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of matrix metallopeptidase secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of matrix metalloproteinase secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of MMP secretion" EXACT [GOC:TermGenie] +is_a: GO:0050714 ! positive regulation of protein secretion +is_a: GO:1904464 ! regulation of matrix metallopeptidase secretion +relationship: positively_regulates GO:1990773 ! matrix metallopeptidase secretion + +[Term] +id: GO:1904470 +name: regulation of endothelin production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +synonym: "regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of endothelin secretion" NARROW [] +synonym: "regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +is_a: GO:0001817 ! regulation of cytokine production +relationship: regulates GO:1990775 ! endothelin production + +[Term] +id: GO:1904471 +name: negative regulation of endothelin production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +synonym: "down regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "down regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "down-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "downregulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of endothelin secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of endothelin secretion" NARROW [] +synonym: "negative regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +is_a: GO:0001818 ! negative regulation of cytokine production +is_a: GO:1904470 ! regulation of endothelin production +relationship: negatively_regulates GO:1990775 ! endothelin production + +[Term] +id: GO:1904472 +name: positive regulation of endothelin production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelin production." [GO_REF:0000058, GOC:TermGenie, PMID:15560120] +synonym: "activation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "activation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "activation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "activation of endothelin secretion" NARROW [GOC:TermGenie] +synonym: "activation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "activation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "activation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of endothelin secretion" NARROW [] +synonym: "positive regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "positive regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "up regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "up-regulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of EDN1 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of EDN2 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of EDN3 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of endothelin secretion" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelin-1 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of endothelin-2 secretion" NARROW [GOC:TermGenie] +synonym: "upregulation of endothelin-3 secretion" NARROW [GOC:TermGenie] +is_a: GO:0001819 ! positive regulation of cytokine production +is_a: GO:1904470 ! regulation of endothelin production +relationship: positively_regulates GO:1990775 ! endothelin production + +[Term] +id: GO:1904473 +name: response to L-dopa +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid +is_a: GO:1904386 ! response to L-phenylalanine derivative + +[Term] +id: GO:1904474 +name: cellular response to L-dopa +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-dopa stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25044243] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904387 ! cellular response to L-phenylalanine derivative +is_a: GO:1904473 ! response to L-dopa + +[Term] +id: GO:1904475 +name: regulation of small GTPase binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] +synonym: "regulation of Ras GTPase binding" NARROW [] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:1904476 +name: negative regulation of small GTPase binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] +synonym: "down regulation of small GTPase binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of Ras GTPase binding" EXACT [GOC:TermGenie] +synonym: "downregulation of small GTPase binding" EXACT [GOC:TermGenie] +synonym: "inhibition of small GTPase binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of Ras GTPase binding" NARROW [] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:1904475 ! regulation of small GTPase binding + +[Term] +id: GO:1904477 +name: positive regulation of small GTPase binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of small GTPase binding." [GO_REF:0000059, GOC:TermGenie, PMID:15798216] +synonym: "activation of Ras GTPase binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of Ras GTPase binding" NARROW [] +synonym: "up regulation of small GTPase binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of small GTPase binding" EXACT [GOC:TermGenie] +synonym: "upregulation of small GTPase binding" EXACT [GOC:TermGenie] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:1904475 ! regulation of small GTPase binding + +[Term] +id: GO:1904478 +name: regulation of intestinal absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0050892 ! intestinal absorption + +[Term] +id: GO:1904479 +name: negative regulation of intestinal absorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] +synonym: "down regulation of intestinal absorption" EXACT [GOC:TermGenie] +synonym: "down-regulation of intestinal absorption" EXACT [GOC:TermGenie] +synonym: "downregulation of intestinal absorption" EXACT [GOC:TermGenie] +synonym: "inhibition of intestinal absorption" NARROW [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:1904478 ! regulation of intestinal absorption +relationship: negatively_regulates GO:0050892 ! intestinal absorption + +[Term] +id: GO:1904480 +name: positive regulation of intestinal absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intestinal absorption." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12469120] +synonym: "activation of intestinal absorption" NARROW [GOC:TermGenie] +synonym: "up regulation of intestinal absorption" EXACT [GOC:TermGenie] +synonym: "up-regulation of intestinal absorption" EXACT [GOC:TermGenie] +synonym: "upregulation of intestinal absorption" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:1904478 ! regulation of intestinal absorption +relationship: positively_regulates GO:0050892 ! intestinal absorption + +[Term] +id: GO:1904481 +name: response to tetrahydrofolate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904482 +name: cellular response to tetrahydrofolate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrahydrofolate stimulus." [GO_REF:0000071, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24698160] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904481 ! response to tetrahydrofolate + +[Term] +id: GO:1904483 +name: synthetic cannabinoid binding +namespace: molecular_function +def: "Binding to synthetic cannabinoid." [GO_REF:0000067, GOC:mr, GOC:TermGenie, PMID:10700562] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1904484 +name: cloacal gland development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure." [GO_REF:0000094, GOC:mr, GOC:TermGenie, PMID:18805421] +is_a: GO:0048732 ! gland development + +[Term] +id: GO:1904486 +name: response to 17alpha-ethynylestradiol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904487 +name: cellular response to 17alpha-ethynylestradiol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 17alpha-ethynylestradiol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18805421] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904486 ! response to 17alpha-ethynylestradiol + +[Term] +id: GO:1904488 +name: regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A positive regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] +synonym: "regulation of reactive oxygen species metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process + +[Term] +id: GO:1904489 +name: regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A negative regulation of transcription from RNA polymerase II promoter that results in regulation of reactive oxygen species metabolic process." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] +synonym: "regulation of reactive oxygen species metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of reactive oxygen species metabolism by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of ROS metabolic process by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process + +[Term] +id: GO:1904490 +name: negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "A negative regulation of transcription from RNA polymerase II promoter that results in negative regulation of mitochondrial unfolded protein response." [GO_REF:0000063, GOC:kmv, GOC:TermGenie, PMID:25961505] +synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitochondrial unfolded protein response by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by down regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by down regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by down-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by down-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by downregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by downregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by inhibition of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by inhibition of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by negative regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "negative regulation of mtUPR by negative regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of mtUPR by negative regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: negatively_regulates GO:0034514 ! mitochondrial unfolded protein response + +[Term] +id: GO:1904491 +name: protein localization to ciliary transition zone +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:21422230] +synonym: "protein localisation in ciliary transition zone" EXACT [GOC:TermGenie] +synonym: "protein localisation to ciliary transition zone" EXACT [GOC:TermGenie] +synonym: "protein localization in ciliary transition zone" EXACT [GOC:TermGenie] +is_a: GO:0061512 ! protein localization to cilium + +[Term] +id: GO:1904492 +name: Ac-Asp-Glu binding +namespace: molecular_function +def: "Binding to Ac-Asp-Glu." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754] +is_a: GO:0043168 ! anion binding +is_a: GO:1900750 ! oligopeptide binding + +[Term] +id: GO:1904493 +name: tetrahydrofolyl-poly(glutamate) polymer binding +namespace: molecular_function +def: "Binding to tetrahydrofolyl-poly(glutamate) polymer." [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:24863754] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1904494 +name: regulation of substance P secretion, neurotransmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:1904458 ! regulation of substance P secretion +relationship: regulates GO:1990793 ! substance P secretion, neurotransmission + +[Term] +id: GO:1904495 +name: negative regulation of substance P secretion, neurotransmission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] +synonym: "down regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "down-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "downregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "inhibition of substance P secretion, neurotransmission" NARROW [GOC:TermGenie] +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:1904459 ! negative regulation of substance P secretion +is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission +relationship: negatively_regulates GO:1990793 ! substance P secretion, neurotransmission + +[Term] +id: GO:1904496 +name: positive regulation of substance P secretion, neurotransmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of substance P secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:15292051] +synonym: "activation of substance P secretion, neurotransmission" NARROW [GOC:TermGenie] +synonym: "up regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "up-regulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "upregulation of substance P secretion, neurotransmission" EXACT [GOC:TermGenie] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:1904460 ! positive regulation of substance P secretion +is_a: GO:1904494 ! regulation of substance P secretion, neurotransmission +relationship: positively_regulates GO:1990793 ! substance P secretion, neurotransmission + +[Term] +id: GO:1904498 +name: protein localization to mitotic actomyosin contractile ring +namespace: biological_process +def: "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25688133] +synonym: "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GOC:TermGenie] +synonym: "protein localization to actomyosin contractile ring during mitotic cytokinesis" RELATED [] +synonym: "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] +synonym: "protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [] +is_a: GO:1903047 ! mitotic cell cycle process +is_a: GO:1990179 ! protein localization to actomyosin contractile ring +relationship: part_of GO:0000281 ! mitotic cytokinesis + +[Term] +id: GO:1904499 +name: obsolete regulation of chromatin-mediated maintenance of transcription +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +comment: This term was obsoleted because it represents a readout. +is_obsolete: true + +[Term] +id: GO:1904500 +name: obsolete negative regulation of chromatin-mediated maintenance of transcription +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +comment: This term was obsoleted because it represents a readout. +synonym: "down regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +synonym: "downregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +synonym: "inhibition of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904501 +name: obsolete positive regulation of chromatin-mediated maintenance of transcription +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chromatin-mediated maintenance of transcription." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +comment: This term was obsoleted because it represents a readout. +synonym: "activation of chromatin-mediated maintenance of transcription" NARROW [GOC:TermGenie] +synonym: "up regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +synonym: "upregulation of chromatin-mediated maintenance of transcription" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904502 +name: regulation of lipophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] +is_a: GO:0016241 ! regulation of macroautophagy +relationship: regulates GO:0061724 ! lipophagy + +[Term] +id: GO:1904503 +name: negative regulation of lipophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] +synonym: "down regulation of lipophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of lipophagy" EXACT [GOC:TermGenie] +synonym: "inhibition of lipophagy" NARROW [GOC:TermGenie] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:1904502 ! regulation of lipophagy +relationship: negatively_regulates GO:0061724 ! lipophagy + +[Term] +id: GO:1904504 +name: positive regulation of lipophagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lipophagy." [GO_REF:0000058, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:25383539] +synonym: "activation of lipophagy" NARROW [GOC:TermGenie] +synonym: "up regulation of lipophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of lipophagy" EXACT [GOC:TermGenie] +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:1904502 ! regulation of lipophagy +relationship: positively_regulates GO:0061724 ! lipophagy + +[Term] +id: GO:1904505 +name: regulation of telomere maintenance in response to DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +is_a: GO:0032204 ! regulation of telomere maintenance +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: regulates GO:0043247 ! telomere maintenance in response to DNA damage + +[Term] +id: GO:1904506 +name: negative regulation of telomere maintenance in response to DNA damage +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "down regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "down regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie] +synonym: "inhibition of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage +is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus +relationship: negatively_regulates GO:0043247 ! telomere maintenance in response to DNA damage + +[Term] +id: GO:1904507 +name: positive regulation of telomere maintenance in response to DNA damage +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "activation of DNA damage response, telomere maintenance" NARROW [GOC:TermGenie] +synonym: "activation of telomere maintenance in response to DNA damage" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "up regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA damage response, telomere maintenance" EXACT [GOC:TermGenie] +synonym: "upregulation of telomere maintenance in response to DNA damage" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage +is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus +relationship: positively_regulates GO:0043247 ! telomere maintenance in response to DNA damage + +[Term] +id: GO:1904508 +name: regulation of protein localization to basolateral plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] +synonym: "regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1904375 ! regulation of protein localization to cell periphery +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: regulates GO:1903361 ! protein localization to basolateral plasma membrane + +[Term] +id: GO:1904509 +name: negative regulation of protein localization to basolateral plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] +synonym: "down regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1904376 ! negative regulation of protein localization to cell periphery +is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane +is_a: GO:1905476 ! negative regulation of protein localization to membrane +relationship: negatively_regulates GO:1903361 ! protein localization to basolateral plasma membrane + +[Term] +id: GO:1904510 +name: positive regulation of protein localization to basolateral plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to basolateral plasma membrane." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26115433] +synonym: "activation of protein localisation in basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to basolateral plasma membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in basolateral plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to basolateral plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1904377 ! positive regulation of protein localization to cell periphery +is_a: GO:1904508 ! regulation of protein localization to basolateral plasma membrane +is_a: GO:1905477 ! positive regulation of protein localization to membrane +relationship: positively_regulates GO:1903361 ! protein localization to basolateral plasma membrane + +[Term] +id: GO:1904511 +name: cytoplasmic microtubule plus-end +namespace: cellular_component +def: "Any microtubule plus-end that is part of a cytoplasmic microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:15772152] +synonym: "growing microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie] +synonym: "growing microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] +synonym: "microtubule plus end of cytoplasmic microtubule" EXACT [GOC:TermGenie] +synonym: "microtubule plus end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] +synonym: "microtubule plus-end of cytoplasmic microtubule" EXACT [GOC:TermGenie] +synonym: "microtubule plus-end of non-spindle-associated astral microtubule" NARROW [GOC:TermGenie] +is_a: GO:0035371 ! microtubule plus-end +relationship: part_of GO:0005881 ! cytoplasmic microtubule + +[Term] +id: GO:1904512 +name: regulation of initiation of premeiotic DNA replication +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] +synonym: "regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation +is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication +is_a: GO:0051445 ! regulation of meiotic cell cycle +relationship: regulates GO:1902974 ! meiotic DNA replication initiation + +[Term] +id: GO:1904513 +name: negative regulation of initiation of premeiotic DNA replication +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] +synonym: "down regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "down regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "down regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "down regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "down-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "down-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "downregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "downregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "downregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "downregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "inhibition of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie] +synonym: "inhibition of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "inhibition of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "inhibition of premeiotic DNA replication initiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "negative regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation +is_a: GO:0051447 ! negative regulation of meiotic cell cycle +is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication +is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication +relationship: negatively_regulates GO:1902974 ! meiotic DNA replication initiation + +[Term] +id: GO:1904514 +name: positive regulation of initiation of premeiotic DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] +synonym: "activation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "activation of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie] +synonym: "activation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "activation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "activation of premeiotic DNA replication initiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "up regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "up regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "up regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "up regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "up-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +synonym: "upregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] +synonym: "upregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] +synonym: "upregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] +synonym: "upregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] +is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication +is_a: GO:0032298 ! positive regulation of DNA-dependent DNA replication initiation +is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:1902974 ! meiotic DNA replication initiation + +[Term] +id: GO:1904515 +name: positive regulation of TORC2 signaling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of TORC2 signaling." [GO_REF:0000058, GOC:TermGenie, PMID:25590601] +synonym: "activation of TORC2 signal transduction" NARROW [GOC:TermGenie] +synonym: "activation of TORC2 signaling" NARROW [GOC:TermGenie] +synonym: "positive regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "up regulation of TORC2 signaling" EXACT [GOC:TermGenie] +synonym: "up-regulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "up-regulation of TORC2 signaling" EXACT [GOC:TermGenie] +synonym: "upregulation of TORC2 signal transduction" EXACT [GOC:TermGenie] +synonym: "upregulation of TORC2 signaling" EXACT [GOC:TermGenie] +is_a: GO:0032008 ! positive regulation of TOR signaling +is_a: GO:1903939 ! regulation of TORC2 signaling +relationship: positively_regulates GO:0038203 ! TORC2 signaling + +[Term] +id: GO:1904516 +name: myofibroblast cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a myofibroblast cell." [GO_REF:0000085, GOC:TermGenie, PMID:23026405] +synonym: "MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1904517 +name: MgATP(2-) binding +namespace: molecular_function +def: "Binding to MgATP(2-)." [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:20086079] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1904518 +name: protein localization to cytoplasmic microtubule plus-end +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:15772152] +synonym: "protein localisation in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] +synonym: "protein localisation to cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] +synonym: "protein localization in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] +is_a: GO:1904825 ! protein localization to microtubule plus-end +is_a: GO:1905755 ! protein localization to cytoplasmic microtubule + +[Term] +id: GO:1904519 +name: protein localization to microtubule minus-end +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end." [GO_REF:0000087, GOC:TermGenie, PMID:25987607] +synonym: "protein localisation in microtubule minus-end" EXACT [GOC:TermGenie] +synonym: "protein localisation to microtubule minus-end" EXACT [GOC:TermGenie] +synonym: "protein localization in microtubule minus-end" EXACT [GOC:TermGenie] +is_a: GO:1905725 ! protein localization to microtubule end + +[Term] +id: GO:1904520 +name: regulation of myofibroblast cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] +synonym: "regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:1904516 ! myofibroblast cell apoptotic process + +[Term] +id: GO:1904521 +name: negative regulation of myofibroblast cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] +synonym: "down regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of MFB apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process +relationship: negatively_regulates GO:1904516 ! myofibroblast cell apoptotic process + +[Term] +id: GO:1904522 +name: positive regulation of myofibroblast cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myofibroblast cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:26119034] +synonym: "activation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of MFB apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of myofibroblast cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of MFB apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of MFB apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of myofibroblast cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of myofibroblast cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:1904520 ! regulation of myofibroblast cell apoptotic process +relationship: positively_regulates GO:1904516 ! myofibroblast cell apoptotic process + +[Term] +id: GO:1904523 +name: regulation of DNA amplification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: regulates GO:0006277 ! DNA amplification + +[Term] +id: GO:1904524 +name: negative regulation of DNA amplification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] +synonym: "down regulation of DNA amplification" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA amplification" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA amplification" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA amplification" NARROW [GOC:TermGenie] +is_a: GO:1904523 ! regulation of DNA amplification +is_a: GO:2000279 ! negative regulation of DNA biosynthetic process +relationship: negatively_regulates GO:0006277 ! DNA amplification + +[Term] +id: GO:1904525 +name: positive regulation of DNA amplification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA amplification." [GO_REF:0000058, GOC:TermGenie, PMID:26195783] +synonym: "activation of DNA amplification" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA amplification" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA amplification" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA amplification" EXACT [GOC:TermGenie] +is_a: GO:1904523 ! regulation of DNA amplification +is_a: GO:2000573 ! positive regulation of DNA biosynthetic process +relationship: positively_regulates GO:0006277 ! DNA amplification + +[Term] +id: GO:1904526 +name: regulation of microtubule binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:1904527 +name: negative regulation of microtubule binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "down regulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "down regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "down regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "down-regulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "downregulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "downregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "inhibition of microtubule binding" NARROW [GOC:TermGenie] +synonym: "inhibition of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "inhibition of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "negative regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:1904526 ! regulation of microtubule binding + +[Term] +id: GO:1904528 +name: positive regulation of microtubule binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of microtubule binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "activation of microtubule binding" NARROW [GOC:TermGenie] +synonym: "activation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "activation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "positive regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "up regulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "up regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "up regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "up-regulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +synonym: "upregulation of microtubule binding" EXACT [GOC:TermGenie] +synonym: "upregulation of microtubule severing activity" RELATED [GOC:TermGenie] +synonym: "upregulation of microtubule/chromatin interaction" RELATED [GOC:TermGenie] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:1904526 ! regulation of microtubule binding + +[Term] +id: GO:1904529 +name: regulation of actin filament binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "regulation of F-actin binding" EXACT [GOC:TermGenie] +is_a: GO:1904616 ! regulation of actin binding + +[Term] +id: GO:1904530 +name: negative regulation of actin filament binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "down regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "down regulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "down regulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "downregulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "downregulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "downregulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "inhibition of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "inhibition of actin filament binding" NARROW [GOC:TermGenie] +synonym: "inhibition of F-actin binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of F-actin binding" EXACT [GOC:TermGenie] +is_a: GO:1904529 ! regulation of actin filament binding +is_a: GO:1904617 ! negative regulation of actin binding + +[Term] +id: GO:1904531 +name: positive regulation of actin filament binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin filament binding." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:24520051] +synonym: "activation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "activation of actin filament binding" NARROW [GOC:TermGenie] +synonym: "activation of F-actin binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "up regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "up regulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "up regulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of F-actin binding" EXACT [GOC:TermGenie] +synonym: "upregulation of actin cross-linking activity" RELATED [GOC:TermGenie] +synonym: "upregulation of actin filament binding" EXACT [GOC:TermGenie] +synonym: "upregulation of F-actin binding" EXACT [GOC:TermGenie] +is_a: GO:1904529 ! regulation of actin filament binding +is_a: GO:1904618 ! positive regulation of actin binding + +[Term] +id: GO:1904532 +name: obsolete ATP-dependent microtubule motor activity, minus-end-directed involved in microtubule-based movement +namespace: molecular_function +def: "OBSOLETE. Any ATP-dependent microtubule motor activity, minus-end-directed that is involved in microtubule-based movement." [GO_REF:0000061, GOC:TermGenie, PMID:25987607] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1904533 +name: regulation of telomeric loop disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "regulation of T loop disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032204 ! regulation of telomere maintenance +relationship: regulates GO:0090657 ! telomeric loop disassembly + +[Term] +id: GO:1904534 +name: negative regulation of telomeric loop disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "down regulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of T loop disassembly" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric loop disassembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of T loop disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032205 ! negative regulation of telomere maintenance +is_a: GO:1904533 ! regulation of telomeric loop disassembly +relationship: negatively_regulates GO:0090657 ! telomeric loop disassembly + +[Term] +id: GO:1904535 +name: positive regulation of telomeric loop disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomeric loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22579284] +synonym: "activation of T loop disassembly" NARROW [GOC:TermGenie] +synonym: "activation of telomeric loop disassembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "up regulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of T loop disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric loop disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032206 ! positive regulation of telomere maintenance +is_a: GO:1904533 ! regulation of telomeric loop disassembly +relationship: positively_regulates GO:0090657 ! telomeric loop disassembly + +[Term] +id: GO:1904536 +name: regulation of mitotic telomere tethering at nuclear periphery +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery + +[Term] +id: GO:1904537 +name: negative regulation of mitotic telomere tethering at nuclear periphery +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic telomere tethering at nuclear periphery." [GO_REF:0000058, GOC:TermGenie, PMID:22959349] +synonym: "down regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic telomere tethering at nuclear periphery" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic telomere tethering at nuclear periphery" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1904536 ! regulation of mitotic telomere tethering at nuclear periphery +relationship: negatively_regulates GO:0044820 ! mitotic telomere tethering at nuclear periphery + +[Term] +id: GO:1904538 +name: regulation of glycolytic process through fructose-6-phosphate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] +synonym: "regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +is_a: GO:0006110 ! regulation of glycolytic process +relationship: regulates GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:1904539 +name: negative regulation of glycolytic process through fructose-6-phosphate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] +synonym: "down regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "down regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "downregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "downregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "inhibition of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie] +synonym: "inhibition of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie] +synonym: "negative regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +is_a: GO:0045820 ! negative regulation of glycolytic process +is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate +relationship: negatively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:1904540 +name: positive regulation of glycolytic process through fructose-6-phosphate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycolytic process through fructose-6-phosphate." [GO_REF:0000058, GOC:dph, GOC:TermGenie, ISBN:0201090910, ISBN:0879010479] +synonym: "activation of glycolysis through fructose-6-phosphate" NARROW [GOC:TermGenie] +synonym: "activation of glycolytic process through fructose-6-phosphate" NARROW [GOC:TermGenie] +synonym: "positive regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "up regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "up regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "upregulation of glycolysis through fructose-6-phosphate" EXACT [GOC:TermGenie] +synonym: "upregulation of glycolytic process through fructose-6-phosphate" EXACT [GOC:TermGenie] +is_a: GO:0045821 ! positive regulation of glycolytic process +is_a: GO:1904538 ! regulation of glycolytic process through fructose-6-phosphate +relationship: positively_regulates GO:0061615 ! glycolytic process through fructose-6-phosphate + +[Term] +id: GO:1904541 +name: fungal-type cell wall disassembly involved in conjugation with cellular fusion +namespace: biological_process +def: "Any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion." [GO_REF:0000060, GOC:TermGenie, PMID:25825517] +synonym: "fungal-type cell wall disassembly involved in cell fusion" RELATED [GOC:TermGenie] +synonym: "fungal-type cell wall disassembly involved in mating" RELATED [GOC:TermGenie] +is_a: GO:0070871 ! cell wall organization involved in conjugation with cellular fusion +is_a: GO:0071853 ! fungal-type cell wall disassembly + +[Term] +id: GO:1904542 +name: regulation of free ubiquitin chain polymerization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] +comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). +is_a: GO:0032271 ! regulation of protein polymerization +relationship: regulates GO:0010994 ! free ubiquitin chain polymerization + +[Term] +id: GO:1904543 +name: negative regulation of free ubiquitin chain polymerization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] +comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). +synonym: "down regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +synonym: "down-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +synonym: "downregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +synonym: "inhibition of free ubiquitin chain polymerization" NARROW [GOC:TermGenie] +is_a: GO:0032272 ! negative regulation of protein polymerization +is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization +relationship: negatively_regulates GO:0010994 ! free ubiquitin chain polymerization + +[Term] +id: GO:1904544 +name: positive regulation of free ubiquitin chain polymerization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of free ubiquitin chain polymerization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24660806] +comment: An example of this is PARK2 in human (UniProt symbol O60260) in PMID:24660806 (inferred from mutant phenotype). +synonym: "activation of free ubiquitin chain polymerization" NARROW [GOC:TermGenie] +synonym: "up regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +synonym: "up-regulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +synonym: "upregulation of free ubiquitin chain polymerization" EXACT [GOC:TermGenie] +is_a: GO:0032273 ! positive regulation of protein polymerization +is_a: GO:1904542 ! regulation of free ubiquitin chain polymerization +relationship: positively_regulates GO:0010994 ! free ubiquitin chain polymerization + +[Term] +id: GO:1904546 +name: obsolete negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway +namespace: biological_process +def: "OBSOLETE. Any negative regulation of cAMP-dependent protein kinase activity that is involved in negative regulation of glucose mediated signaling pathway." [GO_REF:0000060, GOC:TermGenie, PMID:21118717] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of AMPK involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in down-regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in downregulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in inhibition of glucose mediated signalling" NARROW [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity involved in negative regulation of glucose mediated signalling" EXACT [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA C involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of PKA involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of protein kinase A activity involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in down regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in down-regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in downregulation of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in inhibition of glucose mediated signalling" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of STK22 involved in negative regulation of glucose mediated signalling" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904547 +name: regulation of cellular response to glucose starvation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to glucose starvation." [GO_REF:0000058, GOC:TermGenie, PMID:21118717] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0032107 ! regulation of response to nutrient levels +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0042149 ! cellular response to glucose starvation + +[Term] +id: GO:1904550 +name: response to arachidonic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1904551 +name: cellular response to arachidonic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16382163] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:1904550 ! response to arachidonic acid + +[Term] +id: GO:1904552 +name: regulation of chemotaxis to arachidonic acid +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0034670 ! chemotaxis to arachidonic acid + +[Term] +id: GO:1904553 +name: negative regulation of chemotaxis to arachidonic acid +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] +synonym: "down regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +synonym: "down-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +synonym: "downregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +synonym: "inhibition of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid +relationship: negatively_regulates GO:0034670 ! chemotaxis to arachidonic acid + +[Term] +id: GO:1904554 +name: positive regulation of chemotaxis to arachidonic acid +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid." [GO_REF:0000058, GOC:TermGenie, PMID:16382163] +synonym: "activation of chemotaxis to arachidonic acid" NARROW [GOC:TermGenie] +synonym: "up regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +synonym: "up-regulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +synonym: "upregulation of chemotaxis to arachidonic acid" EXACT [GOC:TermGenie] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1904552 ! regulation of chemotaxis to arachidonic acid +relationship: positively_regulates GO:0034670 ! chemotaxis to arachidonic acid + +[Term] +id: GO:1904555 +name: L-proline transmembrane transport +namespace: biological_process +def: "The directed movement of L-proline across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015824 ! proline transport +is_a: GO:0035524 ! proline transmembrane transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1904556 +name: L-tryptophan transmembrane transport +namespace: biological_process +def: "The directed movement of L-tryptophan across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0015827 ! tryptophan transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1904557 +name: L-alanine transmembrane transport +namespace: biological_process +def: "The directed movement of L-alanine across a membrane." [GO_REF:0000069, GOC:kmv, GOC:TermGenie] +is_a: GO:0015808 ! L-alanine transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1904558 +name: response to dextromethorphan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] +is_a: GO:0014072 ! response to isoquinoline alkaloid +is_a: GO:0045472 ! response to ether + +[Term] +id: GO:1904559 +name: cellular response to dextromethorphan +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dextromethorphan stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] +is_a: GO:0071317 ! cellular response to isoquinoline alkaloid +is_a: GO:0071362 ! cellular response to ether +is_a: GO:1904558 ! response to dextromethorphan + +[Term] +id: GO:1904560 +name: response to diphenidol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol + +[Term] +id: GO:1904561 +name: cellular response to diphenidol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diphenidol stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25796330] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1904560 ! response to diphenidol + +[Term] +id: GO:1904562 +name: phosphatidylinositol 5-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588] +synonym: "phosphatidylinositol 5-phosphate metabolism" EXACT [GOC:TermGenie] +is_a: GO:0046488 ! phosphatidylinositol metabolic process + +[Term] +id: GO:1904563 +name: phosphatidylinositol 5-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate." [GO_REF:0000068, GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:23916588] +synonym: "phosphatidylinositol 5-phosphate anabolism" EXACT [GOC:TermGenie] +synonym: "phosphatidylinositol 5-phosphate biosynthesis" EXACT [GOC:TermGenie] +synonym: "phosphatidylinositol 5-phosphate formation" EXACT [GOC:TermGenie] +synonym: "phosphatidylinositol 5-phosphate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046854 ! phosphatidylinositol phosphate biosynthetic process +is_a: GO:1904562 ! phosphatidylinositol 5-phosphate metabolic process + +[Term] +id: GO:1904564 +name: Nbp35-Cfd1 ATPase complex +namespace: cellular_component +def: "An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1." [GO_REF:0000088, GOC:bhm, GOC:rb, GOC:TermGenie, PMID:26195633] +is_a: GO:1904949 ! ATPase complex +is_a: GO:1990229 ! iron-sulfur cluster assembly complex + +[Term] +id: GO:1904565 +name: response to 1-oleoyl-sn-glycerol 3-phosphate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919] +synonym: "response to 1-oleoyl lysophosphatidic acid" EXACT [] +synonym: "response to LPA" EXACT [] +synonym: "response to lysophosphatidic acid" EXACT [] +synonym: "response to oleoyl lysophosphatidic acid" EXACT [] +synonym: "response to oleoyl-L-alpha-lysophosphatidic acid" EXACT [] +is_a: GO:0033993 ! response to lipid +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904566 +name: cellular response to 1-oleoyl-sn-glycerol 3-phosphate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12139919] +synonym: "cellular response to 1-oleoyl lysophosphatidic acid" EXACT [] +synonym: "cellular response to LPA" EXACT [] +synonym: "cellular response to lysophosphatidic acid" EXACT [] +synonym: "cellular response to oleoyl lysophosphatidic acid" EXACT [] +synonym: "cellular response to oleoyl-L-alpha-lysophosphatidic acid" EXACT [] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904565 ! response to 1-oleoyl-sn-glycerol 3-phosphate + +[Term] +id: GO:1904567 +name: response to wortmannin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] +synonym: "response to wartmannin" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904568 +name: cellular response to wortmannin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20629186] +synonym: "cellular response to wartmannin" EXACT [] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904567 ! response to wortmannin + +[Term] +id: GO:1904569 +name: regulation of selenocysteine incorporation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] +is_a: GO:0006448 ! regulation of translational elongation +relationship: regulates GO:0001514 ! selenocysteine incorporation + +[Term] +id: GO:1904570 +name: negative regulation of selenocysteine incorporation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] +synonym: "down regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +synonym: "down-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +synonym: "downregulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +synonym: "inhibition of selenocysteine incorporation" NARROW [GOC:TermGenie] +is_a: GO:0045900 ! negative regulation of translational elongation +is_a: GO:1904569 ! regulation of selenocysteine incorporation +relationship: negatively_regulates GO:0001514 ! selenocysteine incorporation + +[Term] +id: GO:1904571 +name: positive regulation of selenocysteine incorporation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of selenocysteine incorporation." [GO_REF:0000058, GOC:TermGenie, PMID:21685449] +synonym: "activation of selenocysteine incorporation" NARROW [GOC:TermGenie] +synonym: "up regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +synonym: "up-regulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +synonym: "upregulation of selenocysteine incorporation" EXACT [GOC:TermGenie] +is_a: GO:0045901 ! positive regulation of translational elongation +is_a: GO:1904569 ! regulation of selenocysteine incorporation +relationship: positively_regulates GO:0001514 ! selenocysteine incorporation + +[Term] +id: GO:1904572 +name: negative regulation of mRNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] +synonym: "down regulation of mRNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of mRNA binding" NARROW [GOC:TermGenie] +is_a: GO:1902415 ! regulation of mRNA binding +is_a: GO:1905215 ! negative regulation of RNA binding + +[Term] +id: GO:1904573 +name: regulation of selenocysteine insertion sequence binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] +synonym: "regulation of SECIS binding" EXACT [GOC:TermGenie] +is_a: GO:1902415 ! regulation of mRNA binding + +[Term] +id: GO:1904574 +name: negative regulation of selenocysteine insertion sequence binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] +synonym: "down regulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "down regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +synonym: "downregulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "downregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +synonym: "inhibition of SECIS binding" NARROW [GOC:TermGenie] +synonym: "inhibition of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of SECIS binding" EXACT [GOC:TermGenie] +is_a: GO:1904572 ! negative regulation of mRNA binding +is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding + +[Term] +id: GO:1904575 +name: positive regulation of selenocysteine insertion sequence binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." [GO_REF:0000059, GOC:TermGenie, PMID:19716792] +synonym: "activation of SECIS binding" NARROW [GOC:TermGenie] +synonym: "activation of selenocysteine insertion sequence binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "up regulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "up regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +synonym: "upregulation of SECIS binding" EXACT [GOC:TermGenie] +synonym: "upregulation of selenocysteine insertion sequence binding" EXACT [GOC:TermGenie] +is_a: GO:1902416 ! positive regulation of mRNA binding +is_a: GO:1904573 ! regulation of selenocysteine insertion sequence binding + +[Term] +id: GO:1904576 +name: response to tunicamycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1904577 +name: cellular response to tunicamycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tunicamycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904576 ! response to tunicamycin + +[Term] +id: GO:1904578 +name: response to thapsigargin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0033993 ! response to lipid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904579 +name: cellular response to thapsigargin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thapsigargin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23106379] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904578 ! response to thapsigargin + +[Term] +id: GO:1904580 +name: regulation of intracellular mRNA localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] +synonym: "regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0008298 ! intracellular mRNA localization + +[Term] +id: GO:1904581 +name: negative regulation of intracellular mRNA localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] +synonym: "down regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "down regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "down regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "down regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "down regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "down regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "down-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "down-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "downregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "downregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "downregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular mRNA localisation" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular mRNA localization" NARROW [GOC:TermGenie] +synonym: "inhibition of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA localization, intracellular" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "negative regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "negative regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "negative regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1904580 ! regulation of intracellular mRNA localization +relationship: negatively_regulates GO:0008298 ! intracellular mRNA localization + +[Term] +id: GO:1904582 +name: positive regulation of intracellular mRNA localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intracellular mRNA localization." [GO_REF:0000058, GOC:TermGenie, PMID:21471000] +synonym: "activation of establishment and maintenance of intracellular RNA localization" NARROW [GOC:TermGenie] +synonym: "activation of intracellular mRNA localisation" NARROW [GOC:TermGenie] +synonym: "activation of intracellular mRNA localization" NARROW [GOC:TermGenie] +synonym: "activation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "activation of mRNA localization, intracellular" NARROW [GOC:TermGenie] +synonym: "activation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "positive regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "positive regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "positive regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "up regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "up regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "up regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "up regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "up regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "up-regulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "up-regulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +synonym: "upregulation of establishment and maintenance of intracellular RNA localization" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular mRNA localisation" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular mRNA localization" EXACT [GOC:TermGenie] +synonym: "upregulation of intracellular mRNA positioning" NARROW [GOC:TermGenie] +synonym: "upregulation of mRNA localization, intracellular" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA positioning, intracellular" NARROW [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1904580 ! regulation of intracellular mRNA localization +relationship: positively_regulates GO:0008298 ! intracellular mRNA localization + +[Term] +id: GO:1904583 +name: response to polyamine macromolecule +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] +synonym: "response to polyamine" EXACT [] +synonym: "response to polyamines" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1904584 +name: cellular response to polyamine macromolecule +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] +synonym: "cellular response to polyamine" EXACT [] +synonym: "cellular response to polyamines" EXACT [] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904583 ! response to polyamine macromolecule + +[Term] +id: GO:1904585 +name: response to putrescine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] +synonym: "response to 1,4-Butanediamine" EXACT [] +synonym: "response to 1,4-Diaminobutane" EXACT [] +synonym: "response to tetramethylenediamine" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound + +[Term] +id: GO:1904586 +name: cellular response to putrescine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a putrescine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20805360] +synonym: "cellular response to 1,4-Butanediamine" EXACT [] +synonym: "cellular response to 1,4-Diaminobutane" EXACT [] +synonym: "cellular response to tetramethylenediamine" EXACT [] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1904585 ! response to putrescine + +[Term] +id: GO:1904587 +name: response to glycoprotein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] +synonym: "response to glycoproteins" EXACT [] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904588 +name: cellular response to glycoprotein +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14597422] +synonym: "cellular response to glycoproteins" EXACT [] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904587 ! response to glycoprotein + +[Term] +id: GO:1904589 +name: regulation of protein import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] +synonym: "regulation of protein uptake" EXACT [GOC:TermGenie] +is_a: GO:0051223 ! regulation of protein transport +relationship: regulates GO:0017038 ! protein import + +[Term] +id: GO:1904590 +name: negative regulation of protein import +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] +synonym: "down regulation of protein import" EXACT [GOC:TermGenie] +synonym: "down regulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein import" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "downregulation of protein import" EXACT [GOC:TermGenie] +synonym: "downregulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "inhibition of protein import" NARROW [GOC:TermGenie] +synonym: "inhibition of protein uptake" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein uptake" EXACT [GOC:TermGenie] +is_a: GO:0051224 ! negative regulation of protein transport +is_a: GO:1904589 ! regulation of protein import +relationship: negatively_regulates GO:0017038 ! protein import + +[Term] +id: GO:1904591 +name: positive regulation of protein import +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein import." [GO_REF:0000058, GOC:TermGenie, PMID:11406629] +synonym: "activation of protein import" NARROW [GOC:TermGenie] +synonym: "activation of protein uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "up regulation of protein import" EXACT [GOC:TermGenie] +synonym: "up regulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein import" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein uptake" EXACT [GOC:TermGenie] +synonym: "upregulation of protein import" EXACT [GOC:TermGenie] +synonym: "upregulation of protein uptake" EXACT [GOC:TermGenie] +is_a: GO:0051222 ! positive regulation of protein transport +is_a: GO:1904589 ! regulation of protein import +relationship: positively_regulates GO:0017038 ! protein import + +[Term] +id: GO:1904592 +name: positive regulation of protein refolding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein refolding." [GO_REF:0000058, GOC:TermGenie, PMID:11360998] +synonym: "activation of heat shock protein activity" RELATED [GOC:TermGenie] +synonym: "activation of protein refolding" NARROW [GOC:TermGenie] +synonym: "positive regulation of heat shock protein activity" RELATED [GOC:TermGenie] +synonym: "up regulation of heat shock protein activity" RELATED [GOC:TermGenie] +synonym: "up regulation of protein refolding" EXACT [GOC:TermGenie] +synonym: "up-regulation of heat shock protein activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein refolding" EXACT [GOC:TermGenie] +synonym: "upregulation of heat shock protein activity" RELATED [GOC:TermGenie] +synonym: "upregulation of protein refolding" EXACT [GOC:TermGenie] +is_a: GO:0061083 ! regulation of protein refolding +is_a: GO:1903334 ! positive regulation of protein folding +relationship: positively_regulates GO:0042026 ! protein refolding + +[Term] +id: GO:1904593 +name: prostaglandin binding +namespace: molecular_function +def: "Binding to prostaglandin." [GO_REF:0000067, GOC:TermGenie, PMID:21445266] +is_a: GO:1901567 ! fatty acid derivative binding + +[Term] +id: GO:1904594 +name: regulation of termination of RNA polymerase II transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108] +synonym: "regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] +synonym: "regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination +relationship: regulates GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:1904595 +name: positive regulation of termination of RNA polymerase II transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription." [GO_REF:0000058, GOC:TermGenie, PMID:25417108] +synonym: "activation of RNA 3'-end formation by RNA polymerase II" NARROW [GOC:TermGenie] +synonym: "activation of RNA polymerase II transcription termination" NARROW [GOC:TermGenie] +synonym: "activation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "activation of termination of RNA polymerase II transcription" NARROW [GOC:TermGenie] +synonym: "activation of transcription termination from Pol II promoter" NARROW [GOC:TermGenie] +synonym: "activation of transcription termination from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] +synonym: "positive regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] +synonym: "up regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "up regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA 3'-end formation by RNA polymerase II" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA polymerase II transcription termination" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA polymerase II transcription termination factor activity" RELATED [GOC:TermGenie] +synonym: "upregulation of termination of RNA polymerase II transcription" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription termination from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of transcription termination from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination +is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription +relationship: positively_regulates GO:0006369 ! termination of RNA polymerase II transcription + +[Term] +id: GO:1904596 +name: regulation of connective tissue replacement involved in inflammatory response wound healing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] +synonym: "regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +is_a: GO:1905203 ! regulation of connective tissue replacement +relationship: regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing + +[Term] +id: GO:1904597 +name: negative regulation of connective tissue replacement involved in inflammatory response wound healing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] +synonym: "down regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "down regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "down regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "down-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "down-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "down-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "downregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "downregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "downregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "inhibition of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "inhibition of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie] +synonym: "inhibition of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "negative regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "negative regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing +is_a: GO:1905204 ! negative regulation of connective tissue replacement +relationship: negatively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing + +[Term] +id: GO:1904598 +name: positive regulation of connective tissue replacement involved in inflammatory response wound healing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement involved in inflammatory response wound healing." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:18245812] +synonym: "activation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "activation of connective tissue replacement involved in inflammatory response wound healing" NARROW [GOC:TermGenie] +synonym: "activation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "positive regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "positive regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "up regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "up regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "up regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "up-regulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "up-regulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "up-regulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +synonym: "upregulation of connective tissue replacement during inflammatory response" RELATED [GOC:TermGenie] +synonym: "upregulation of connective tissue replacement involved in inflammatory response wound healing" EXACT [GOC:TermGenie] +synonym: "upregulation of fibrosis during inflammatory response" NARROW [GOC:TermGenie] +is_a: GO:1904596 ! regulation of connective tissue replacement involved in inflammatory response wound healing +is_a: GO:1905205 ! positive regulation of connective tissue replacement +relationship: positively_regulates GO:0002248 ! connective tissue replacement involved in inflammatory response wound healing + +[Term] +id: GO:1904599 +name: advanced glycation end-product binding +namespace: molecular_function +def: "Binding to advanced glycation end-product." [GO_REF:0000067, GOC:krc, GOC:TermGenie, PMID:1650387] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:1904600 +name: actin fusion focus assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus." [GO_REF:0000079, GOC:TermGenie, PMID:25825517] +synonym: "actin fusion focus formation" EXACT [GOC:TermGenie] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0030036 ! actin cytoskeleton organization +relationship: part_of GO:0031382 ! mating projection formation + +[Term] +id: GO:1904601 +name: protein localization to actin fusion focus +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an actin fusion focus." [GO_REF:0000087, GOC:TermGenie, PMID:25825517] +synonym: "protein localisation in actin fusion focus" EXACT [GOC:TermGenie] +synonym: "protein localisation to actin fusion focus" EXACT [GOC:TermGenie] +synonym: "protein localization in actin fusion focus" EXACT [GOC:TermGenie] +is_a: GO:1903119 ! protein localization to actin cytoskeleton +is_a: GO:1903260 ! protein localization to mating projection tip + +[Term] +id: GO:1904602 +name: serotonin-activated cation-selective channel complex +namespace: cellular_component +def: "A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092] +comment: An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay). +synonym: "5-HT-3 receptor complex" EXACT [] +synonym: "5-HT3 receptor complex" EXACT [] +synonym: "5-hydroxytryptamine receptor 3 complex" EXACT [] +synonym: "5HT3 receptor complex" EXACT [] +synonym: "serotonin receptor complex" BROAD [] +is_a: GO:0034703 ! cation channel complex +is_a: GO:0098878 ! neurotransmitter receptor complex + +[Term] +id: GO:1904603 +name: regulation of advanced glycation end-product receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] +synonym: "regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "regulation of RAGE activity" EXACT [GOC:TermGenie] +is_a: GO:0010469 ! regulation of signaling receptor activity + +[Term] +id: GO:1904604 +name: negative regulation of advanced glycation end-product receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] +synonym: "down regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "downregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "inhibition of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of AGE receptor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of RAGE activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of RAGE activity" EXACT [GOC:TermGenie] +is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity +is_a: GO:2000272 ! negative regulation of signaling receptor activity + +[Term] +id: GO:1904605 +name: positive regulation of advanced glycation end-product receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of advanced glycation end-product receptor activity." [GO_REF:0000059, GOC:krc, GOC:TermGenie, PMID:16503878] +synonym: "activation of advanced glycation end-product receptor activity" NARROW [GOC:TermGenie] +synonym: "activation of AGE receptor activity" NARROW [GOC:TermGenie] +synonym: "activation of RAGE activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "up regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RAGE activity" EXACT [GOC:TermGenie] +synonym: "upregulation of advanced glycation end-product receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of AGE receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RAGE activity" EXACT [GOC:TermGenie] +is_a: GO:1904603 ! regulation of advanced glycation end-product receptor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:1904606 +name: fat cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a fat cell." [GO_REF:0000085, GOC:TermGenie, PMID:17024416] +synonym: "adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "fat cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1904608 +name: response to monosodium L-glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115] +is_a: GO:1904008 ! response to monosodium glutamate + +[Term] +id: GO:1904609 +name: cellular response to monosodium L-glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21389115] +is_a: GO:1904009 ! cellular response to monosodium glutamate +is_a: GO:1904608 ! response to monosodium L-glutamate + +[Term] +id: GO:1904610 +name: response to 3,3',4,4',5-pentachlorobiphenyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +synonym: "response to PCB 126" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1904611 +name: cellular response to 3,3',4,4',5-pentachlorobiphenyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',4,4',5-pentachlorobiphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +synonym: "cellular response to PCB 126" EXACT [] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904610 ! response to 3,3',4,4',5-pentachlorobiphenyl + +[Term] +id: GO:1904612 +name: response to 2,3,7,8-tetrachlorodibenzodioxine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +synonym: "response to dioxin" EXACT [] +synonym: "response to TCDD" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1904613 +name: cellular response to 2,3,7,8-tetrachlorodibenzodioxine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +synonym: "cellular response to dioxin" EXACT [] +synonym: "cellular response to TCDD" EXACT [] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904612 ! response to 2,3,7,8-tetrachlorodibenzodioxine + +[Term] +id: GO:1904614 +name: response to biphenyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1904615 +name: cellular response to biphenyl +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biphenyl stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23196670] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904614 ! response to biphenyl + +[Term] +id: GO:1904616 +name: regulation of actin binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] +synonym: "regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:1904617 +name: negative regulation of actin binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] +synonym: "down regulation of actin binding" EXACT [GOC:TermGenie] +synonym: "down regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "down-regulation of actin binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "downregulation of actin binding" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "inhibition of actin binding" NARROW [GOC:TermGenie] +synonym: "inhibition of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:1904616 ! regulation of actin binding + +[Term] +id: GO:1904618 +name: positive regulation of actin binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin binding." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:8621557] +synonym: "activation of actin binding" NARROW [GOC:TermGenie] +synonym: "activation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "up regulation of actin binding" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "up-regulation of actin binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane associated actin binding" NARROW [GOC:TermGenie] +synonym: "upregulation of actin binding" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane associated actin binding" NARROW [GOC:TermGenie] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:1904616 ! regulation of actin binding + +[Term] +id: GO:1904619 +name: response to dimethyl sulfoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] +synonym: "response to DMSO" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1904620 +name: cellular response to dimethyl sulfoxide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dimethyl sulfoxide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:12873812] +synonym: "cellular response to DMSO" EXACT [] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904619 ! response to dimethyl sulfoxide + +[Term] +id: GO:1904624 +name: regulation of glycine secretion, neurotransmission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:0051955 ! regulation of amino acid transport +is_a: GO:0060092 ! regulation of synaptic transmission, glycinergic +relationship: regulates GO:0061537 ! glycine secretion, neurotransmission + +[Term] +id: GO:1904625 +name: negative regulation of glycine secretion, neurotransmission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] +synonym: "down regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "downregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "inhibition of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:0060093 ! negative regulation of synaptic transmission, glycinergic +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission +relationship: negatively_regulates GO:0061537 ! glycine secretion, neurotransmission + +[Term] +id: GO:1904626 +name: positive regulation of glycine secretion, neurotransmission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." [GO_REF:0000058, GOC:TermGenie, PMID:22988142] +synonym: "activation of glycine secretion, neurotransmission" NARROW [GOC:TermGenie] +synonym: "up regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +synonym: "upregulation of glycine secretion, neurotransmission" EXACT [GOC:TermGenie] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:0060094 ! positive regulation of synaptic transmission, glycinergic +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:1904624 ! regulation of glycine secretion, neurotransmission +relationship: positively_regulates GO:0061537 ! glycine secretion, neurotransmission + +[Term] +id: GO:1904627 +name: response to phorbol 13-acetate 12-myristate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903] +synonym: "response to phorbol 12-tetradecanoate 13-acetate" EXACT [] +synonym: "response to PMA" EXACT [] +synonym: "response to tetradecanoylphorbol acetate" EXACT [] +synonym: "response to TPA" EXACT [] +is_a: GO:0033993 ! response to lipid +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904628 +name: cellular response to phorbol 13-acetate 12-myristate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:2200903] +synonym: "cellular response to phorbol 12-tetradecanoate 13-acetate" EXACT [] +synonym: "cellular response to response to PMA" EXACT [] +synonym: "cellular response to tetradecanoylphorbol acetate" EXACT [] +synonym: "cellular response to TPA" EXACT [] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904627 ! response to phorbol 13-acetate 12-myristate + +[Term] +id: GO:1904629 +name: response to diterpene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1904630 +name: cellular response to diterpene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diterpene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19765580] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1904629 ! response to diterpene + +[Term] +id: GO:1904631 +name: response to glucoside +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873] +synonym: "response to glucosides" EXACT [] +is_a: GO:1903416 ! response to glycoside + +[Term] +id: GO:1904632 +name: cellular response to glucoside +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucoside stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16842873] +synonym: "cellular response to glucosides" EXACT [] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904631 ! response to glucoside + +[Term] +id: GO:1904633 +name: regulation of glomerular visceral epithelial cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] +synonym: "regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process + +[Term] +id: GO:1904634 +name: negative regulation of glomerular visceral epithelial cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] +synonym: "down regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of podocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process +relationship: negatively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process + +[Term] +id: GO:1904635 +name: positive regulation of glomerular visceral epithelial cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glomerular visceral epithelial cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:23692924] +synonym: "activation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of glomerular podocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of glomerular visceral epithelial cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of podocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of glomerular podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of glomerular podocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of glomerular visceral epithelial cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of glomerular visceral epithelial cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of podocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of podocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:1904633 ! regulation of glomerular visceral epithelial cell apoptotic process +relationship: positively_regulates GO:1903210 ! glomerular visceral epithelial cell apoptotic process + +[Term] +id: GO:1904636 +name: response to ionomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1904637 +name: cellular response to ionomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17516843] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1904636 ! response to ionomycin + +[Term] +id: GO:1904638 +name: response to resveratrol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] +is_a: GO:0035634 ! response to stilbenoid +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904639 +name: cellular response to resveratrol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a resveratrol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904638 ! response to resveratrol + +[Term] +id: GO:1904640 +name: response to methionine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:17716000] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1904641 +name: response to dinitrophenol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883] +synonym: "response to dinitrophenols" RELATED [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904642 +name: cellular response to dinitrophenol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dinitrophenol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24336883] +synonym: "cellular response to dinitrophenols" RELATED [] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904641 ! response to dinitrophenol + +[Term] +id: GO:1904643 +name: response to curcumin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904644 +name: cellular response to curcumin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a curcumin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24755072] +is_a: GO:0071362 ! cellular response to ether +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904643 ! response to curcumin + +[Term] +id: GO:1904645 +name: response to amyloid-beta +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] +synonym: "response to beta-amyloid" EXACT [] +synonym: "response to beta-amyloids" RELATED [] +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:1904646 +name: cellular response to amyloid-beta +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23555824] +synonym: "cellular response to beta-amyloid" EXACT [] +synonym: "cellular response to beta-amyloids" RELATED [] +is_a: GO:1901653 ! cellular response to peptide +is_a: GO:1904645 ! response to amyloid-beta + +[Term] +id: GO:1904647 +name: response to rotenone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1904648 +name: cellular response to rotenone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18538940] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1904647 ! response to rotenone + +[Term] +id: GO:1904649 +name: regulation of fat cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] +synonym: "regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:1904606 ! fat cell apoptotic process + +[Term] +id: GO:1904650 +name: negative regulation of fat cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] +synonym: "down regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of adipocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of adipose cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of fat cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:1904649 ! regulation of fat cell apoptotic process +relationship: negatively_regulates GO:1904606 ! fat cell apoptotic process + +[Term] +id: GO:1904651 +name: positive regulation of fat cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:17024416] +synonym: "activation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of adipocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of adipose cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of fat cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of adipocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of adipocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of adipose cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of adipose cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of fat cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of fat cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:1904649 ! regulation of fat cell apoptotic process +relationship: positively_regulates GO:1904606 ! fat cell apoptotic process + +[Term] +id: GO:1904652 +name: protein localization to cell division site involved in cell separation after cytokinesis +namespace: biological_process +def: "Any protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334] +is_a: GO:0072741 ! protein localization to cell division site +relationship: part_of GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:1904653 +name: regulation of lung alveolus development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] +synonym: "regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "regulation of alveologenesis" EXACT [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048286 ! lung alveolus development + +[Term] +id: GO:1904654 +name: negative regulation of lung alveolus development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] +synonym: "down regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "down regulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of lung alveolus development" EXACT [GOC:TermGenie] +synonym: "down-regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of lung alveolus development" EXACT [GOC:TermGenie] +synonym: "downregulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of lung alveolus development" EXACT [GOC:TermGenie] +synonym: "inhibition of alveolarization" NARROW [GOC:TermGenie] +synonym: "inhibition of alveologenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of lung alveolus development" NARROW [GOC:TermGenie] +synonym: "negative regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "negative regulation of alveologenesis" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904653 ! regulation of lung alveolus development +relationship: negatively_regulates GO:0048286 ! lung alveolus development + +[Term] +id: GO:1904655 +name: positive regulation of lung alveolus development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lung alveolus development." [GO_REF:0000058, GOC:TermGenie, PMID:23962064] +synonym: "activation of alveolarization" NARROW [GOC:TermGenie] +synonym: "activation of alveologenesis" NARROW [GOC:TermGenie] +synonym: "activation of lung alveolus development" NARROW [GOC:TermGenie] +synonym: "positive regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "positive regulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "up regulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of lung alveolus development" EXACT [GOC:TermGenie] +synonym: "up-regulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of lung alveolus development" EXACT [GOC:TermGenie] +synonym: "upregulation of alveolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of alveologenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of lung alveolus development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904653 ! regulation of lung alveolus development +relationship: positively_regulates GO:0048286 ! lung alveolus development + +[Term] +id: GO:1904656 +name: regulation of sensory perception of sweet taste +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "regulation of sweet taste perception" EXACT [GOC:TermGenie] +is_a: GO:0051931 ! regulation of sensory perception +relationship: regulates GO:0050916 ! sensory perception of sweet taste + +[Term] +id: GO:1904657 +name: negative regulation of sensory perception of sweet taste +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "down regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "down regulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "down-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "down-regulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "downregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "downregulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "inhibition of sensory perception of sweet taste" NARROW [GOC:TermGenie] +synonym: "inhibition of sweet taste perception" NARROW [GOC:TermGenie] +synonym: "negative regulation of sweet taste perception" EXACT [GOC:TermGenie] +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:1904656 ! regulation of sensory perception of sweet taste +relationship: negatively_regulates GO:0050916 ! sensory perception of sweet taste + +[Term] +id: GO:1904658 +name: positive regulation of sensory perception of sweet taste +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sensory perception of sweet taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "activation of sensory perception of sweet taste" NARROW [GOC:TermGenie] +synonym: "activation of sweet taste perception" NARROW [GOC:TermGenie] +synonym: "positive regulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "up regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "up regulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "up-regulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "up-regulation of sweet taste perception" EXACT [GOC:TermGenie] +synonym: "upregulation of sensory perception of sweet taste" EXACT [GOC:TermGenie] +synonym: "upregulation of sweet taste perception" EXACT [GOC:TermGenie] +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:1904656 ! regulation of sensory perception of sweet taste +relationship: positively_regulates GO:0050916 ! sensory perception of sweet taste + +[Term] +id: GO:1904659 +name: glucose transmembrane transport +namespace: biological_process +alt_id: GO:0015758 +def: "The process in which glucose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:9090050] +synonym: "glucose transport" RELATED [] +is_a: GO:0008645 ! hexose transmembrane transport + +[Term] +id: GO:1904660 +name: regulation of sensory perception of bitter taste +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "regulation of bitter taste perception" EXACT [GOC:TermGenie] +is_a: GO:0051931 ! regulation of sensory perception +relationship: regulates GO:0050913 ! sensory perception of bitter taste + +[Term] +id: GO:1904661 +name: negative regulation of sensory perception of bitter taste +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "down regulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "down regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +synonym: "down-regulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "down-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +synonym: "downregulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "downregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +synonym: "inhibition of bitter taste perception" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory perception of bitter taste" NARROW [GOC:TermGenie] +synonym: "negative regulation of bitter taste perception" EXACT [GOC:TermGenie] +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:1904660 ! regulation of sensory perception of bitter taste +relationship: negatively_regulates GO:0050913 ! sensory perception of bitter taste + +[Term] +id: GO:1904662 +name: positive regulation of sensory perception of bitter taste +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sensory perception of bitter taste." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:1716172] +synonym: "activation of bitter taste perception" NARROW [GOC:TermGenie] +synonym: "activation of sensory perception of bitter taste" NARROW [GOC:TermGenie] +synonym: "positive regulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "up regulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "up regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +synonym: "up-regulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "up-regulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +synonym: "upregulation of bitter taste perception" EXACT [GOC:TermGenie] +synonym: "upregulation of sensory perception of bitter taste" EXACT [GOC:TermGenie] +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:1904660 ! regulation of sensory perception of bitter taste +relationship: positively_regulates GO:0050913 ! sensory perception of bitter taste + +[Term] +id: GO:1904663 +name: regulation of N-terminal peptidyl-methionine acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] +is_a: GO:1901983 ! regulation of protein acetylation +is_a: GO:1903317 ! regulation of protein maturation +relationship: regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation + +[Term] +id: GO:1904664 +name: negative regulation of N-terminal peptidyl-methionine acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] +is_a: GO:1901984 ! negative regulation of protein acetylation +is_a: GO:1903318 ! negative regulation of protein maturation +is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation +relationship: negatively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation + +[Term] +id: GO:1904665 +name: positive regulation of N-terminal peptidyl-methionine acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-methionine acetylation." [GO_REF:0000058, GOC:TermGenie, PMID:20807799] +is_a: GO:1901985 ! positive regulation of protein acetylation +is_a: GO:1903319 ! positive regulation of protein maturation +is_a: GO:1904663 ! regulation of N-terminal peptidyl-methionine acetylation +relationship: positively_regulates GO:0017196 ! N-terminal peptidyl-methionine acetylation + +[Term] +id: GO:1904666 +name: regulation of ubiquitin protein ligase activity +namespace: biological_process +alt_id: GO:1903834 +def: "Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] +synonym: "regulation of APC-fizzy related complex activity" NARROW [] +synonym: "regulation of E3" RELATED [GOC:TermGenie] +synonym: "regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity + +[Term] +id: GO:1904667 +name: negative regulation of ubiquitin protein ligase activity +namespace: biological_process +alt_id: GO:0060564 +alt_id: GO:1904190 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:tb, GOC:TermGenie, PMID:26216882] +synonym: "down regulation of E3" RELATED [GOC:TermGenie] +synonym: "down regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of E3" RELATED [GOC:TermGenie] +synonym: "down-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of E3" RELATED [GOC:TermGenie] +synonym: "downregulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of E3" RELATED [GOC:TermGenie] +synonym: "inhibition of protein ubiquitination activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquitin ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquitin protein ligase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of anaphase-promoting complex activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of APC activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of APC-Cdc20 complex activity" NARROW [] +synonym: "negative regulation of APC-fizzy related complex activity" NARROW [] +synonym: "negative regulation of APC/C activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of cyclosome activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] +synonym: "negative regulation of E3" RELATED [GOC:TermGenie] +synonym: "negative regulation of mitotic anaphase-promoting complex activity" RELATED [GOC:vw] +synonym: "negative regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity +is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity + +[Term] +id: GO:1904668 +name: positive regulation of ubiquitin protein ligase activity +namespace: biological_process +alt_id: GO:0007092 +alt_id: GO:0051488 +alt_id: GO:0090623 +alt_id: GO:1903835 +def: "Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity." [GO_REF:0000059, GOC:dph, GOC:TermGenie, GOC:vw, PMID:10921876, PMID:26216882] +synonym: "activation of anaphase-promoting complex activity" NARROW [] +synonym: "activation of APC-Cdc20 complex activity" NARROW [] +synonym: "activation of APC-fizzy related complex activity" NARROW [] +synonym: "activation of E3" RELATED [GOC:TermGenie] +synonym: "activation of protein ubiquitination activity" NARROW [GOC:TermGenie] +synonym: "activation of ubiquitin ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of ubiquitin protein ligase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of APC-fizzy related complex activity" NARROW [] +synonym: "positive regulation of E3" RELATED [GOC:TermGenie] +synonym: "positive regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ubiquitin ligase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] +synonym: "up regulation of E3" RELATED [GOC:TermGenie] +synonym: "up regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of E3" RELATED [GOC:TermGenie] +synonym: "up-regulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of APC-fizzy related complex activity" NARROW [GOC:TermGenie] +synonym: "upregulation of E3" RELATED [GOC:TermGenie] +synonym: "upregulation of protein ubiquitination activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquitin ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquitin protein ligase activity" EXACT [GOC:TermGenie] +is_a: GO:0051443 ! positive regulation of ubiquitin-protein transferase activity +is_a: GO:1904666 ! regulation of ubiquitin protein ligase activity + +[Term] +id: GO:1904669 +name: ATP export +namespace: biological_process +def: "The directed movement of ATP out of a cell or organelle." [GO_REF:0000074, GOC:TermGenie, PMID:24286344] +synonym: "ATP efflux" RELATED [] +is_a: GO:0015867 ! ATP transport + +[Term] +id: GO:1904670 +name: actin filament polymerization involved in mitotic actomyosin contractile ring assembly +namespace: biological_process +def: "Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly." [GO_REF:0000060, GOC:TermGenie, PMID:24127216] +is_a: GO:0030041 ! actin filament polymerization +is_a: GO:1903479 ! mitotic actomyosin contractile ring assembly actin filament organization + +[Term] +id: GO:1904671 +name: negative regulation of cell differentiation involved in stem cell population maintenance +namespace: biological_process +def: "Any negative regulation of cell differentiation that is involved in stem cell population maintenance." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "down regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "down regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "downregulation of cell differentiation involved in stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "inhibition of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] +synonym: "inhibition of cell differentiation involved in stem cell population maintenance" NARROW [GOC:TermGenie] +synonym: "negative regulation of cell differentiation involved in maintenance of pluripotency" RELATED [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +relationship: part_of GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:1904672 +name: regulation of somatic stem cell population maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +is_a: GO:2000036 ! regulation of stem cell population maintenance +relationship: regulates GO:0035019 ! somatic stem cell population maintenance + +[Term] +id: GO:1904673 +name: negative regulation of somatic stem cell population maintenance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "down regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "down-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "downregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "inhibition of somatic stem cell population maintenance" NARROW [GOC:TermGenie] +is_a: GO:1902455 ! negative regulation of stem cell population maintenance +is_a: GO:1904672 ! regulation of somatic stem cell population maintenance +relationship: negatively_regulates GO:0035019 ! somatic stem cell population maintenance + +[Term] +id: GO:1904674 +name: positive regulation of somatic stem cell population maintenance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell population maintenance." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "activation of somatic stem cell population maintenance" NARROW [GOC:TermGenie] +synonym: "up regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "up-regulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +synonym: "upregulation of somatic stem cell population maintenance" EXACT [GOC:TermGenie] +is_a: GO:1902459 ! positive regulation of stem cell population maintenance +is_a: GO:1904672 ! regulation of somatic stem cell population maintenance +relationship: positively_regulates GO:0035019 ! somatic stem cell population maintenance + +[Term] +id: GO:1904675 +name: regulation of somatic stem cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:2000035 ! regulation of stem cell division +relationship: regulates GO:0048103 ! somatic stem cell division + +[Term] +id: GO:1904676 +name: negative regulation of somatic stem cell division +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "down regulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "down regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "down-regulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "down-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "downregulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "downregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "inhibition of somatic stem cell division" NARROW [GOC:TermGenie] +synonym: "inhibition of somatic stem cell renewal" NARROW [GOC:TermGenie] +synonym: "negative regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:0051782 ! negative regulation of cell division +is_a: GO:1904675 ! regulation of somatic stem cell division +relationship: negatively_regulates GO:0048103 ! somatic stem cell division + +[Term] +id: GO:1904677 +name: positive regulation of somatic stem cell division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of somatic stem cell division." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19409607] +synonym: "activation of somatic stem cell division" NARROW [GOC:TermGenie] +synonym: "activation of somatic stem cell renewal" NARROW [GOC:TermGenie] +synonym: "positive regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "up regulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "up regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "up-regulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "up-regulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +synonym: "upregulation of somatic stem cell division" EXACT [GOC:TermGenie] +synonym: "upregulation of somatic stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:0051781 ! positive regulation of cell division +is_a: GO:1904675 ! regulation of somatic stem cell division +relationship: positively_regulates GO:0048103 ! somatic stem cell division + +[Term] +id: GO:1904678 +name: alpha-aminoacyl-tRNA binding +namespace: molecular_function +def: "Binding to an alpha-aminoacyl-tRNA." [GO_REF:0000067, GOC:TermGenie, ISBN:155581073X] +synonym: "aminoacyl-tRNA binding" RELATED [] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:1904679 +name: myo-inositol import across plasma membrane +namespace: biological_process +alt_id: GO:0097357 +def: "The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:9560432] +synonym: "myo-inositol import into cell" EXACT [] +is_a: GO:0015798 ! myo-inositol transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:1904680 +name: peptide transmembrane transporter activity +namespace: molecular_function +alt_id: GO:0015197 +alt_id: GO:0015637 +def: "Enables the transfer of a peptide from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, GOC:vw] +synonym: "peptide transporter activity" RELATED [] +synonym: "peptide uptake permease activity" RELATED [] +xref: Reactome:R-HSA-1500817 "Glutathione is taken up by the bacterium" +is_a: GO:0042887 ! amide transmembrane transporter activity + +[Term] +id: GO:1904681 +name: response to 3-methylcholanthrene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771] +is_a: GO:1903165 ! response to polycyclic arene + +[Term] +id: GO:1904682 +name: cellular response to 3-methylcholanthrene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3-methylcholanthrene stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:9224771] +is_a: GO:1903166 ! cellular response to polycyclic arene +is_a: GO:1904681 ! response to 3-methylcholanthrene + +[Term] +id: GO:1904683 +name: regulation of metalloendopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] +synonym: "regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0052548 ! regulation of endopeptidase activity +is_a: GO:1905048 ! regulation of metallopeptidase activity + +[Term] +id: GO:1904684 +name: negative regulation of metalloendopeptidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] +synonym: "down regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "down regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "downregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendopeptidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of metalloendoprotease activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0010951 ! negative regulation of endopeptidase activity +is_a: GO:1904683 ! regulation of metalloendopeptidase activity +is_a: GO:1905049 ! negative regulation of metallopeptidase activity + +[Term] +id: GO:1904685 +name: positive regulation of metalloendopeptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:18591254] +synonym: "activation of metalloendopeptidase activity" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "activation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of metalloendopeptidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloendoprotease activity" NARROW [GOC:TermGenie] +synonym: "upregulation of metalloendoproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0010950 ! positive regulation of endopeptidase activity +is_a: GO:1904683 ! regulation of metalloendopeptidase activity +is_a: GO:1905050 ! positive regulation of metallopeptidase activity + +[Term] +id: GO:1904686 +name: regulation of mitotic spindle disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819] +synonym: "regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] +synonym: "regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] +synonym: "regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] +synonym: "regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] +is_a: GO:0060236 ! regulation of mitotic spindle organization +relationship: regulates GO:0051228 ! mitotic spindle disassembly + +[Term] +id: GO:1904687 +name: positive regulation of mitotic spindle disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic spindle disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:25963819] +synonym: "activation of mitotic spindle breakdown" NARROW [GOC:TermGenie] +synonym: "activation of mitotic spindle catabolism" NARROW [GOC:TermGenie] +synonym: "activation of mitotic spindle degradation" NARROW [GOC:TermGenie] +synonym: "activation of mitotic spindle disassembly" NARROW [GOC:TermGenie] +synonym: "activation of spindle breakdown during mitosis" NARROW [GOC:TermGenie] +synonym: "activation of spindle degradation during mitosis" NARROW [GOC:TermGenie] +synonym: "activation of spindle disassembly during mitosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic spindle degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic spindle breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic spindle catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic spindle degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic spindle disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle breakdown during mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle degradation during mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle disassembly during mitosis" EXACT [GOC:TermGenie] +is_a: GO:0110028 ! positive regulation of mitotic spindle organization +is_a: GO:1904686 ! regulation of mitotic spindle disassembly +relationship: positively_regulates GO:0051228 ! mitotic spindle disassembly + +[Term] +id: GO:1904688 +name: regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:2000765 ! regulation of cytoplasmic translation +relationship: regulates GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:1904689 +name: negative regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie] +is_a: GO:0045947 ! negative regulation of translational initiation +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +relationship: negatively_regulates GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:1904690 +name: positive regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +is_a: GO:0045948 ! positive regulation of translational initiation +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +relationship: positively_regulates GO:0002183 ! cytoplasmic translational initiation + +[Term] +id: GO:1904691 +name: negative regulation of type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] +synonym: "down regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of pancreatic B cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation +relationship: negatively_regulates GO:0044342 ! type B pancreatic cell proliferation + +[Term] +id: GO:1904692 +name: positive regulation of type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:24055447] +synonym: "activation of pancreatic B cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of pancreatic beta cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of type B pancreatic cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic B cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of pancreatic beta cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of type B pancreatic cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:0061469 ! regulation of type B pancreatic cell proliferation +relationship: positively_regulates GO:0044342 ! type B pancreatic cell proliferation + +[Term] +id: GO:1904693 +name: midbrain morphogenesis +namespace: biological_process +def: "The developmental process by which a midbrain is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] +synonym: "MB morphogenesis" BROAD [GOC:TermGenie] +synonym: "mesencephalon morphogenesis" RELATED [GOC:TermGenie] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0030901 ! midbrain development +relationship: part_of GO:0048854 ! brain morphogenesis + +[Term] +id: GO:1904694 +name: negative regulation of vascular associated smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] +synonym: "down regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle contraction" EXACT [] +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction +is_a: GO:0045906 ! negative regulation of vasoconstriction +is_a: GO:0045986 ! negative regulation of smooth muscle contraction +relationship: negatively_regulates GO:0014829 ! vascular associated smooth muscle contraction + +[Term] +id: GO:1904695 +name: positive regulation of vascular associated smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22158624] +synonym: "activation of vascular smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle contraction" EXACT [] +synonym: "up regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction +is_a: GO:0045907 ! positive regulation of vasoconstriction +is_a: GO:0045987 ! positive regulation of smooth muscle contraction +relationship: positively_regulates GO:0014829 ! vascular associated smooth muscle contraction + +[Term] +id: GO:1904697 +name: regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:1990863 ! acinar cell proliferation + +[Term] +id: GO:1904698 +name: negative regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "down regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of acinar cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of acinic cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of acinous cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:1904697 ! regulation of acinar cell proliferation +relationship: negatively_regulates GO:1990863 ! acinar cell proliferation + +[Term] +id: GO:1904699 +name: positive regulation of acinar cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acinar cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:9788538] +synonym: "activation of acinar cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of acinic cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of acinous cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acinous cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinar cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinic cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of acinous cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:1904697 ! regulation of acinar cell proliferation +relationship: positively_regulates GO:1990863 ! acinar cell proliferation + +[Term] +id: GO:1904700 +name: granulosa cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a granulosa cell." [GO_REF:0000085, GOC:TermGenie, PMID:19208546] +synonym: "granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1904701 +name: Wnt-Frizzled-LRP5/6 complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt-Frizzled-LRP5/6 complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11448771] +synonym: "Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] +synonym: "Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "Wnt receptor complex assembly" BROAD [GOC:bf] +synonym: "WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904702 +name: regulation of protein localization to adherens junction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] +synonym: "regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +is_a: GO:0150106 ! regulation of protein localization to cell-cell junction +relationship: regulates GO:0071896 ! protein localization to adherens junction + +[Term] +id: GO:1904703 +name: negative regulation of protein localization to adherens junction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] +synonym: "down regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +is_a: GO:0150119 ! negative regulation of protein localization to cell-cell junction +is_a: GO:1904702 ! regulation of protein localization to adherens junction +relationship: negatively_regulates GO:0071896 ! protein localization to adherens junction + +[Term] +id: GO:1904704 +name: positive regulation of protein localization to adherens junction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:kmv, GOC:TermGenie, PMID:26412237] +synonym: "activation of protein localisation in cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to cell-cell adherens junction" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in cell-cell adherens junction" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cell-cell adherens junction" EXACT [GOC:TermGenie] +is_a: GO:0150107 ! positive regulation of protein localization to cell-cell junction +is_a: GO:1904702 ! regulation of protein localization to adherens junction +relationship: positively_regulates GO:0071896 ! protein localization to adherens junction + +[Term] +id: GO:1904705 +name: regulation of vascular associated smooth muscle cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] +synonym: "regulation of vascular smooth muscle cell proliferation" EXACT [] +synonym: "regulation of VSMC proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048660 ! regulation of smooth muscle cell proliferation +relationship: regulates GO:1990874 ! vascular associated smooth muscle cell proliferation + +[Term] +id: GO:1904706 +name: negative regulation of vascular associated smooth muscle cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] +synonym: "down regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of VSMC proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell proliferation" EXACT [] +synonym: "negative regulation of VSMC proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048662 ! negative regulation of smooth muscle cell proliferation +is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation +relationship: negatively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation + +[Term] +id: GO:1904707 +name: positive regulation of vascular associated smooth muscle cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:23246467] +synonym: "activation of vascular smooth muscle cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of VSMC proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell proliferation" EXACT [] +synonym: "positive regulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of VSMC proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of VSMC proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048661 ! positive regulation of smooth muscle cell proliferation +is_a: GO:1904705 ! regulation of vascular associated smooth muscle cell proliferation +relationship: positively_regulates GO:1990874 ! vascular associated smooth muscle cell proliferation + +[Term] +id: GO:1904708 +name: regulation of granulosa cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] +synonym: "regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:1904700 ! granulosa cell apoptotic process + +[Term] +id: GO:1904709 +name: negative regulation of granulosa cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] +synonym: "down regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of granulosa cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:1904708 ! regulation of granulosa cell apoptotic process +relationship: negatively_regulates GO:1904700 ! granulosa cell apoptotic process + +[Term] +id: GO:1904710 +name: positive regulation of granulosa cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of granulosa cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:19208546] +synonym: "activation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of granulosa cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of granulosa cell of ovary apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of granulosa cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of granulosa cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of granulosa cell of ovary apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of granulosa cell of ovary apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:1904708 ! regulation of granulosa cell apoptotic process +relationship: positively_regulates GO:1904700 ! granulosa cell apoptotic process + +[Term] +id: GO:1904711 +name: regulation of Wnt-Frizzled-LRP5/6 complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] +synonym: "regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt receptor complex assembly" BROAD [GOC:TermGenie] +synonym: "regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly + +[Term] +id: GO:1904712 +name: positive regulation of Wnt-Frizzled-LRP5/6 complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "activation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie] +synonym: "activation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] +synonym: "positive regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "up regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "up regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "upregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "upregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly +relationship: positively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly + +[Term] +id: GO:1904713 +name: beta-catenin destruction complex binding +namespace: molecular_function +def: "Binding to a beta-catenin destruction complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650] +synonym: "23S APC complex binding" NARROW [GOC:TermGenie] +synonym: "APC-Axin-1-beta-catenin complex binding" EXACT [GOC:TermGenie] +synonym: "Axin-APC-beta-catenin-GSK3B complex binding" EXACT [GOC:TermGenie] +synonym: "BDC binding" EXACT [PMID:22899650] +synonym: "beta-catenin degradation complex binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904714 +name: regulation of chaperone-mediated autophagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] +synonym: "regulation of CMA" RELATED [GOC:TermGenie] +is_a: GO:0010506 ! regulation of autophagy +is_a: GO:0042176 ! regulation of protein catabolic process +relationship: regulates GO:0061684 ! chaperone-mediated autophagy + +[Term] +id: GO:1904715 +name: negative regulation of chaperone-mediated autophagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] +synonym: "down regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "down regulation of CMA" RELATED [GOC:TermGenie] +synonym: "down-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of CMA" RELATED [GOC:TermGenie] +synonym: "downregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "downregulation of CMA" RELATED [GOC:TermGenie] +synonym: "inhibition of chaperone-mediated autophagy" NARROW [GOC:TermGenie] +synonym: "inhibition of CMA" RELATED [GOC:TermGenie] +synonym: "negative regulation of CMA" RELATED [GOC:TermGenie] +is_a: GO:0010507 ! negative regulation of autophagy +is_a: GO:0042177 ! negative regulation of protein catabolic process +is_a: GO:1904714 ! regulation of chaperone-mediated autophagy +relationship: negatively_regulates GO:0061684 ! chaperone-mediated autophagy + +[Term] +id: GO:1904716 +name: positive regulation of chaperone-mediated autophagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chaperone-mediated autophagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20176123] +synonym: "activation of chaperone-mediated autophagy" NARROW [GOC:TermGenie] +synonym: "activation of CMA" RELATED [GOC:TermGenie] +synonym: "positive regulation of CMA" RELATED [GOC:TermGenie] +synonym: "up regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "up regulation of CMA" RELATED [GOC:TermGenie] +synonym: "up-regulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of CMA" RELATED [GOC:TermGenie] +synonym: "upregulation of chaperone-mediated autophagy" EXACT [GOC:TermGenie] +synonym: "upregulation of CMA" RELATED [GOC:TermGenie] +is_a: GO:0010508 ! positive regulation of autophagy +is_a: GO:0045732 ! positive regulation of protein catabolic process +is_a: GO:1904714 ! regulation of chaperone-mediated autophagy +relationship: positively_regulates GO:0061684 ! chaperone-mediated autophagy + +[Term] +id: GO:1904717 +name: regulation of AMPA glutamate receptor clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] +synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:0106104 ! regulation of glutamate receptor clustering +relationship: regulates GO:0097113 ! AMPA glutamate receptor clustering + +[Term] +id: GO:1904718 +name: negative regulation of AMPA glutamate receptor clustering +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] +synonym: "down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "down regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "down regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "down-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "downregulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie] +synonym: "inhibition of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie] +synonym: "inhibition of AMPA receptor clustering" NARROW [GOC:TermGenie] +synonym: "negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "negative regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1901627 ! negative regulation of postsynaptic membrane organization +is_a: GO:1903910 ! negative regulation of receptor clustering +is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering +relationship: negatively_regulates GO:0097113 ! AMPA glutamate receptor clustering + +[Term] +id: GO:1904719 +name: positive regulation of AMPA glutamate receptor clustering +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] +synonym: "activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" NARROW [GOC:TermGenie] +synonym: "activation of AMPA glutamate receptor clustering" NARROW [GOC:TermGenie] +synonym: "activation of AMPA receptor clustering" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "positive regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "up regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "up-regulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of AMPA glutamate receptor clustering" EXACT [GOC:TermGenie] +synonym: "upregulation of AMPA receptor clustering" EXACT [GOC:TermGenie] +is_a: GO:1901628 ! positive regulation of postsynaptic membrane organization +is_a: GO:1903911 ! positive regulation of receptor clustering +is_a: GO:1904717 ! regulation of AMPA glutamate receptor clustering +relationship: positively_regulates GO:0097113 ! AMPA glutamate receptor clustering + +[Term] +id: GO:1904720 +name: obsolete regulation of mRNA endonucleolytic cleavage involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063, PMID:20625543] +comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. +synonym: "regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:1903895 + +[Term] +id: GO:1904721 +name: obsolete negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19328063] +comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. +synonym: "down regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "down regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "down regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "down regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "down-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "down-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "down-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "down-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "down-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "downregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "downregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "downregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "downregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "downregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "inhibition of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "inhibition of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "inhibition of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "inhibition of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie] +synonym: "inhibition of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "negative regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "negative regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "negative regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "negative regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:1903895 + +[Term] +id: GO:1904722 +name: obsolete positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of mRNA endonucleolytic cleavage involved in unfolded protein response." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:20625543] +comment: The reason for obsoletion is that this process being regulated (GO:0070055 mRNA endonucleolytic cleavage involved in unfolded protein response) was obsoleted. +synonym: "activation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "activation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "activation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "activation of mRNA endonucleolytic cleavage involved in unfolded protein response" NARROW [GOC:TermGenie] +synonym: "activation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "positive regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "positive regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "positive regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "positive regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "up regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up-regulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up-regulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "up-regulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "up-regulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "up-regulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "upregulation of HAC1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "upregulation of HAC1-type intron splice site recognition and cleavage" NARROW [GOC:TermGenie] +synonym: "upregulation of IRE1-mediated XBP-1 mRNA cleavage" NARROW [GOC:TermGenie] +synonym: "upregulation of mRNA endonucleolytic cleavage involved in unfolded protein response" EXACT [GOC:TermGenie] +synonym: "upregulation of XBP1 mRNA cleavage" NARROW [GOC:TermGenie] +is_obsolete: true +consider: GO:1903896 + +[Term] +id: GO:1904723 +name: negative regulation of Wnt-Frizzled-LRP5/6 complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11433302] +synonym: "down regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "down regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "downregulation of Frizzled-LRP5/6 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "downregulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "inhibition of Frizzled-LRP5/6 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "inhibition of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt-FZD-LRP5/6 trimeric complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of Frizzled-LRP5/6 complex assembly" RELATED [GOC:bf] +synonym: "negative regulation of Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of WNT-FZD-LRP5 complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of WNT-FZD-LRP5 complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt-FZD-LRP5/6 trimeric complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of WNT-FZD-LRP6 complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of WNT-FZD-LRP6 complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-induced Frizzled-LRP5/6 complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1904711 ! regulation of Wnt-Frizzled-LRP5/6 complex assembly +relationship: negatively_regulates GO:1904701 ! Wnt-Frizzled-LRP5/6 complex assembly + +[Term] +id: GO:1904724 +name: tertiary granule lumen +namespace: cellular_component +def: "Any membrane-enclosed lumen that is part of a tertiary granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] +synonym: "gelatinase granule membrane-enclosed lumen" RELATED [] +synonym: "membrane-enclosed lumen of gelatinase granule" EXACT [GOC:TermGenie] +synonym: "membrane-enclosed lumen of tertiary granule" EXACT [GOC:TermGenie] +synonym: "tertiary granule membrane-enclosed lumen" EXACT [] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0070820 ! tertiary granule + +[Term] +id: GO:1904725 +name: obsolete TFIIB-class transcription factor binding involved in negative regulation of transcription +namespace: molecular_function +def: "OBSOLETE. Any TFIIB-class transcription factor binding that is involved in negative regulation of DNA-templated transcription." [GO_REF:0000061, GOC:rb, GOC:TermGenie, PMID:12461786] +comment: The reason for obsoletion is that this term represents a GO-CAM model. +synonym: "TFIIB-class transcription factor binding involved in down regulation of gene-specific transcription" RELATED [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in down regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in down-regulation of gene-specific transcription" RELATED [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in down-regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in downregulation of gene-specific transcription" RELATED [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in downregulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in inhibition of gene-specific transcription" RELATED [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in inhibition of transcription, DNA-dependent" NARROW [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in negative regulation of cellular transcription, DNA-dependent" EXACT [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in negative regulation of gene-specific transcription" RELATED [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-dependent" EXACT [GOC:TermGenie] +synonym: "TFIIB-class transcription factor binding involved in negative regulation of transcription, DNA-templated" EXACT [] +synonym: "TFIIB-class transcription factor binding involved in transcription repressor activity" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904726 +name: regulation of replicative senescence +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] +is_a: GO:0090342 ! regulation of cell aging +relationship: regulates GO:0090399 ! replicative senescence + +[Term] +id: GO:1904727 +name: negative regulation of replicative senescence +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] +synonym: "down regulation of replicative senescence" EXACT [GOC:TermGenie] +synonym: "down-regulation of replicative senescence" EXACT [GOC:TermGenie] +synonym: "downregulation of replicative senescence" EXACT [GOC:TermGenie] +synonym: "inhibition of replicative senescence" NARROW [GOC:TermGenie] +is_a: GO:0090344 ! negative regulation of cell aging +is_a: GO:1904726 ! regulation of replicative senescence +relationship: negatively_regulates GO:0090399 ! replicative senescence + +[Term] +id: GO:1904728 +name: positive regulation of replicative senescence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of replicative senescence." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23496142] +synonym: "activation of replicative senescence" NARROW [GOC:TermGenie] +synonym: "up regulation of replicative senescence" EXACT [GOC:TermGenie] +synonym: "up-regulation of replicative senescence" EXACT [GOC:TermGenie] +synonym: "upregulation of replicative senescence" EXACT [GOC:TermGenie] +is_a: GO:0090343 ! positive regulation of cell aging +is_a: GO:1904726 ! regulation of replicative senescence +relationship: positively_regulates GO:0090399 ! replicative senescence + +[Term] +id: GO:1904729 +name: regulation of intestinal lipid absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:1904478 ! regulation of intestinal absorption +relationship: regulates GO:0098856 ! intestinal lipid absorption + +[Term] +id: GO:1904730 +name: negative regulation of intestinal lipid absorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] +synonym: "down regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +synonym: "down-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +synonym: "downregulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +synonym: "inhibition of intestinal lipid absorption" NARROW [GOC:TermGenie] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:1904479 ! negative regulation of intestinal absorption +is_a: GO:1904729 ! regulation of intestinal lipid absorption +relationship: negatively_regulates GO:0098856 ! intestinal lipid absorption + +[Term] +id: GO:1904731 +name: positive regulation of intestinal lipid absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption." [GO_REF:0000058, GOC:TermGenie, PMID:18768481] +synonym: "activation of intestinal lipid absorption" NARROW [GOC:TermGenie] +synonym: "up regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +synonym: "up-regulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +synonym: "upregulation of intestinal lipid absorption" EXACT [GOC:TermGenie] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:1904480 ! positive regulation of intestinal absorption +is_a: GO:1904729 ! regulation of intestinal lipid absorption +relationship: positively_regulates GO:0098856 ! intestinal lipid absorption + +[Term] +id: GO:1904732 +name: regulation of electron transfer activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] +synonym: "regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "regulation of azurin" NARROW [GOC:TermGenie] +synonym: "regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "regulation of electron transporter activity" EXACT [GOC:TermGenie] +synonym: "regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1904733 +name: negative regulation of electron transfer activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] +synonym: "down regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "down regulation of azurin" NARROW [GOC:TermGenie] +synonym: "down regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "down regulation of electron carrier activity" EXACT [GOC:TermGenie] +synonym: "down regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "down regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "down regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "down regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "down regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "down regulation of electron transporter activity" EXACT [GOC:TermGenie] +synonym: "down regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "down regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "down regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "down-regulation of azurin" NARROW [GOC:TermGenie] +synonym: "down-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron carrier activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "down-regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "down-regulation of electron transporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "down-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "down-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "downregulation of azurin" NARROW [GOC:TermGenie] +synonym: "downregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "downregulation of electron carrier activity" EXACT [GOC:TermGenie] +synonym: "downregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "downregulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "downregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "downregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "downregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "downregulation of electron transporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "downregulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "downregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of amicyanin" NARROW [GOC:TermGenie] +synonym: "inhibition of azurin" NARROW [GOC:TermGenie] +synonym: "inhibition of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of electron carrier activity" NARROW [GOC:TermGenie] +synonym: "inhibition of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "inhibition of electron donor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "inhibition of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "inhibition of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "inhibition of electron transporter activity" NARROW [GOC:TermGenie] +synonym: "inhibition of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of rubredoxin" NARROW [GOC:TermGenie] +synonym: "inhibition of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "inhibition of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "negative regulation of azurin" NARROW [GOC:TermGenie] +synonym: "negative regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "negative regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "negative regulation of electron transporter activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "negative regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:1904732 ! regulation of electron transfer activity + +[Term] +id: GO:1904734 +name: positive regulation of electron transfer activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of electron transfer activity." [GO_REF:0000059, GOC:TermGenie, PMID:25416781] +synonym: "activation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "activation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "activation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of amicyanin" NARROW [GOC:TermGenie] +synonym: "activation of azurin" NARROW [GOC:TermGenie] +synonym: "activation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "activation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "activation of electron carrier activity" NARROW [GOC:TermGenie] +synonym: "activation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "activation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "activation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "activation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "activation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "activation of electron transporter activity" NARROW [GOC:TermGenie] +synonym: "activation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "activation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "activation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "activation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "activation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "activation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "activation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "activation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "positive regulation of azurin" NARROW [GOC:TermGenie] +synonym: "positive regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "positive regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "positive regulation of electron transporter activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "positive regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "up regulation of azurin" NARROW [GOC:TermGenie] +synonym: "up regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "up regulation of electron carrier activity" RELATED [GOC:TermGenie] +synonym: "up regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "up regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "up regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "up regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "up regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "up regulation of electron transporter activity" RELATED [GOC:TermGenie] +synonym: "up regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "up regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "up regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "up-regulation of azurin" NARROW [GOC:TermGenie] +synonym: "up-regulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron carrier activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "up-regulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "up-regulation of electron transporter activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "up-regulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "up-regulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of 2Fe-2S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of 3Fe-4S/4Fe-4S electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of adrenodoxin-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of amicyanin" NARROW [GOC:TermGenie] +synonym: "upregulation of azurin" NARROW [GOC:TermGenie] +synonym: "upregulation of bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of chloroplast-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of copper electron carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of dicluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of electron acceptor activity" NARROW [GOC:TermGenie] +synonym: "upregulation of electron carrier activity" RELATED [GOC:TermGenie] +synonym: "upregulation of electron carrier, chlorophyll electron transport system" RELATED [GOC:TermGenie] +synonym: "upregulation of electron donor activity" NARROW [GOC:TermGenie] +synonym: "upregulation of electron transfer flavoprotein" NARROW [GOC:TermGenie] +synonym: "upregulation of electron transfer flavoprotein, group I" NARROW [GOC:TermGenie] +synonym: "upregulation of electron transfer flavoprotein, group II" NARROW [GOC:TermGenie] +synonym: "upregulation of electron transporter activity" RELATED [GOC:TermGenie] +synonym: "upregulation of high-potential iron-sulfur carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of iron-sulfur electron transfer carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of monocluster bacterial-type ferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of mononuclear iron electron carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of polyferredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of redox-active disulfide bond electron carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of rubredoxin" NARROW [GOC:TermGenie] +synonym: "upregulation of small blue copper electron carrier" NARROW [GOC:TermGenie] +synonym: "upregulation of thioredoxin-like 2Fe-2S ferredoxin" NARROW [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1904732 ! regulation of electron transfer activity + +[Term] +id: GO:1904735 +name: regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] +is_a: GO:0031998 ! regulation of fatty acid beta-oxidation +relationship: regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase + +[Term] +id: GO:1904736 +name: negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] +synonym: "down regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +synonym: "down-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +synonym: "downregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +synonym: "inhibition of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie] +is_a: GO:0031999 ! negative regulation of fatty acid beta-oxidation +is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase +relationship: negatively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase + +[Term] +id: GO:1904737 +name: positive regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation using acyl-CoA dehydrogenase." [GO_REF:0000058, GOC:TermGenie, PMID:25416781] +synonym: "activation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" NARROW [GOC:TermGenie] +synonym: "up regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +synonym: "up-regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +synonym: "upregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase" EXACT [GOC:TermGenie] +is_a: GO:0032000 ! positive regulation of fatty acid beta-oxidation +is_a: GO:1904735 ! regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase +relationship: positively_regulates GO:0033539 ! fatty acid beta-oxidation using acyl-CoA dehydrogenase + +[Term] +id: GO:1904738 +name: vascular associated smooth muscle cell migration +namespace: biological_process +def: "The orderly movement of a vascular associated smooth muscle cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] +synonym: "vascular smooth muscle cell migration" EXACT [] +is_a: GO:0014909 ! smooth muscle cell migration + +[Term] +id: GO:1904739 +name: regulation of synapse organization by posttranscriptional regulation of gene expression +namespace: biological_process +def: "A posttranscriptional regulation of gene expression that results in regulation of synapse organization." [GO_REF:0000063, GOC:rb, GOC:TermGenie, PMID:20729808] +synonym: "regulation of synapse development by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] +synonym: "regulation of synapse morphogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] +synonym: "regulation of synapse organisation by posttranscriptional regulation of gene expression" EXACT [GOC:TermGenie] +synonym: "regulation of synapse organization and biogenesis by posttranscriptional regulation of gene expression" RELATED [GOC:TermGenie] +is_a: GO:0010608 ! posttranscriptional regulation of gene expression +is_a: GO:0050807 ! regulation of synapse organization + +[Term] +id: GO:1904740 +name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by general transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by RNA polymerase II transcription factor activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by transcription from Pol II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904741 +name: obsolete positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation." [GO_REF:0000063, GOC:rn, GOC:TermGenie, PMID:26448198] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by activation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by positive regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of global transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of global transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of filamentous growth of a population of unicellular organisms in response to starvation by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904742 +name: regulation of telomeric DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:1904743 +name: negative regulation of telomeric DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "down regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "downregulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "inhibition of telomere binding" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric repeat binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:1904742 ! regulation of telomeric DNA binding + +[Term] +id: GO:1904744 +name: positive regulation of telomeric DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "activation of telomere binding" NARROW [GOC:TermGenie] +synonym: "activation of telomeric DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of telomeric repeat binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "up regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric repeat binding" EXACT [GOC:TermGenie] +synonym: "upregulation of telomere binding" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric repeat binding" EXACT [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:1904742 ! regulation of telomeric DNA binding + +[Term] +id: GO:1904745 +name: Atg1/ULK1 kinase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988] +synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904746 +name: negative regulation of apoptotic process involved in development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] +comment: U4PR86 in PMID:22801495 inferred from mutant phenotype +synonym: "down regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "down-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "down-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "down-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "down-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "downregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "downregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "downregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "downregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "downregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "downregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "downregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "downregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "downregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "downregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "downregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "downregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "downregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "downregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "downregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "downregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "inhibition of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "inhibition of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "inhibition of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "inhibition of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "inhibition of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "inhibition of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "inhibition of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "inhibition of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "inhibition of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "inhibition of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "inhibition of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "negative regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "negative regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "negative regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "negative regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "negative regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "negative regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "negative regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "negative regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "negative regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "negative regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "negative regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "negative regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "negative regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: negatively_regulates GO:1902742 ! apoptotic process involved in development + +[Term] +id: GO:1904747 +name: positive regulation of apoptotic process involved in development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] +comment: U4PR86 in PMID:22801495 inferred from mutant phenotype +synonym: "activation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "activation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process involved in development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic process involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of apoptotic programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "activation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "activation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "activation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "activation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "activation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "activation of programmed cell death by apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of programmed cell death by apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "activation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "activation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "activation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "activation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "positive regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "positive regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "positive regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "positive regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "positive regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "positive regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "positive regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "positive regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "positive regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "positive regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up-regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up-regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up-regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up-regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "up-regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up-regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up-regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up-regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up-regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up-regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up-regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "up-regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "up-regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "up-regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "upregulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "upregulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "upregulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "upregulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "upregulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "upregulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "upregulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "upregulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "upregulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "upregulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "upregulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "upregulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "upregulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "upregulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "upregulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "upregulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1904748 ! regulation of apoptotic process involved in development +relationship: positively_regulates GO:1902742 ! apoptotic process involved in development + +[Term] +id: GO:1904748 +name: regulation of apoptotic process involved in development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic process involved in development." [GO_REF:0000058, GOC:TermGenie, PMID:22801495] +comment: Q10943 in PMID:22801495, inferred from mutant phenotype +synonym: "regulation of activation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "regulation of activation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "regulation of apoptosis activator activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "regulation of apoptosis activator activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "regulation of apoptosis involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptosis involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "regulation of apoptosis signaling involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptosis signaling involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic process involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic process involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic program involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic program involved in development of an anatomical structure" NARROW [GOC:TermGenie] +synonym: "regulation of apoptotic programmed cell death involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "regulation of apoptotic programmed cell death involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "regulation of commitment to apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "regulation of commitment to apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "regulation of induction of apoptosis by p53 involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "regulation of induction of apoptosis by p53 involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "regulation of induction of apoptosis involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "regulation of induction of apoptosis involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "regulation of programmed cell death by apoptosis involved in anatomical structure development" EXACT [GOC:TermGenie] +synonym: "regulation of programmed cell death by apoptosis involved in development of an anatomical structure" EXACT [GOC:TermGenie] +synonym: "regulation of signaling (initiator) caspase activity involved in anatomical structure development" RELATED [GOC:TermGenie] +synonym: "regulation of signaling (initiator) caspase activity involved in development of an anatomical structure" RELATED [GOC:TermGenie] +synonym: "regulation of type I programmed cell death involved in anatomical structure development" NARROW [GOC:TermGenie] +synonym: "regulation of type I programmed cell death involved in development of an anatomical structure" NARROW [GOC:TermGenie] +is_a: GO:0042981 ! regulation of apoptotic process +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:1902742 ! apoptotic process involved in development + +[Term] +id: GO:1904749 +name: regulation of protein localization to nucleolus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +is_a: GO:1900180 ! regulation of protein localization to nucleus +relationship: regulates GO:1902570 ! protein localization to nucleolus + +[Term] +id: GO:1904750 +name: negative regulation of protein localization to nucleolus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "down regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in nucleolus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to nucleolus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in nucleolus" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to nucleolus" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +is_a: GO:1900181 ! negative regulation of protein localization to nucleus +is_a: GO:1904749 ! regulation of protein localization to nucleolus +relationship: negatively_regulates GO:1902570 ! protein localization to nucleolus + +[Term] +id: GO:1904751 +name: positive regulation of protein localization to nucleolus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24415760] +synonym: "activation of protein localisation in nucleolus" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to nucleolus" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in nucleolus" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to nucleolus" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in nucleolus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to nucleolus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in nucleolus" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to nucleolus" EXACT [GOC:TermGenie] +is_a: GO:1900182 ! positive regulation of protein localization to nucleus +is_a: GO:1904749 ! regulation of protein localization to nucleolus +relationship: positively_regulates GO:1902570 ! protein localization to nucleolus + +[Term] +id: GO:1904752 +name: regulation of vascular associated smooth muscle cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] +synonym: "regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +is_a: GO:0014910 ! regulation of smooth muscle cell migration +relationship: regulates GO:1904738 ! vascular associated smooth muscle cell migration + +[Term] +id: GO:1904753 +name: negative regulation of vascular associated smooth muscle cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] +synonym: "down regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +is_a: GO:0014912 ! negative regulation of smooth muscle cell migration +is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration +relationship: negatively_regulates GO:1904738 ! vascular associated smooth muscle cell migration + +[Term] +id: GO:1904754 +name: positive regulation of vascular associated smooth muscle cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20693317] +synonym: "activation of vascular associated smooth muscle cell migration" NARROW [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell migration" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell migration" EXACT [GOC:TermGenie] +is_a: GO:0014911 ! positive regulation of smooth muscle cell migration +is_a: GO:1904752 ! regulation of vascular associated smooth muscle cell migration +relationship: positively_regulates GO:1904738 ! vascular associated smooth muscle cell migration + +[Term] +id: GO:1904755 +name: regulation of gut granule assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] +synonym: "regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of gut granule formation" EXACT [GOC:TermGenie] +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:1902900 ! gut granule assembly + +[Term] +id: GO:1904756 +name: negative regulation of gut granule assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] +synonym: "down regulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "downregulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "inhibition of gut granule assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of gut granule biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of gut granule formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of gut granule formation" EXACT [GOC:TermGenie] +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:1904755 ! regulation of gut granule assembly +relationship: negatively_regulates GO:1902900 ! gut granule assembly + +[Term] +id: GO:1904757 +name: positive regulation of gut granule assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gut granule assembly." [GO_REF:0000058, GOC:TermGenie, PMID:17535251] +synonym: "activation of gut granule assembly" NARROW [GOC:TermGenie] +synonym: "activation of gut granule biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of gut granule formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "up regulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gut granule formation" EXACT [GOC:TermGenie] +synonym: "upregulation of gut granule assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of gut granule biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gut granule formation" EXACT [GOC:TermGenie] +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:1904755 ! regulation of gut granule assembly +relationship: positively_regulates GO:1902900 ! gut granule assembly + +[Term] +id: GO:1904758 +name: protein localization to new growing cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a new growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:19431238] +synonym: "protein localisation in new growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localisation to new growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization in new growing cell tip" EXACT [GOC:TermGenie] +synonym: "protein localization to new cell tip after activation of bipolar cell growth" EXACT [] +synonym: "protein localization to new growing cell end" EXACT [] +synonym: "protein localization to post-NETO new cell end" EXACT [] +synonym: "protein localization to post-NETO new cell tip" EXACT [] +synonym: "protein localization to post-new end take-off new cell tip" EXACT [] +is_a: GO:1902486 ! protein localization to growing cell tip + +[Term] +id: GO:1904759 +name: protein localization to equatorial microtubule organizing center +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an equatorial microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:16611237] +synonym: "protein localisation in equatorial microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localisation to equatorial microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localization in equatorial microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localization to eMTOC" EXACT [] +is_a: GO:0072741 ! protein localization to cell division site +is_a: GO:1905508 ! protein localization to microtubule organizing center + +[Term] +id: GO:1904760 +name: regulation of myofibroblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] +synonym: "regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0036446 ! myofibroblast differentiation + +[Term] +id: GO:1904761 +name: negative regulation of myofibroblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] +synonym: "down regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of myofibroblast cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of myofibroblast differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1904760 ! regulation of myofibroblast differentiation +relationship: negatively_regulates GO:0036446 ! myofibroblast differentiation + +[Term] +id: GO:1904762 +name: positive regulation of myofibroblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myofibroblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548] +synonym: "activation of myofibroblast cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of myofibroblast differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of myofibroblast cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of myofibroblast differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1904760 ! regulation of myofibroblast differentiation +relationship: positively_regulates GO:0036446 ! myofibroblast differentiation + +[Term] +id: GO:1904763 +name: chaperone-mediated autophagy translocation complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871] +synonym: "chaperone-mediated autophagy receptor complex assembly" RELATED [GOC:TermGenie] +synonym: "chaperone-mediated autophagy receptor complex formation" RELATED [GOC:TermGenie] +synonym: "chaperone-mediated autophagy translocation complex formation" EXACT [GOC:TermGenie] +synonym: "CMA receptor complex assembly" RELATED [GOC:TermGenie] +synonym: "CMA receptor complex formation" RELATED [GOC:TermGenie] +synonym: "CMA translocation complex assembly" EXACT [GOC:TermGenie] +synonym: "CMA translocation complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly +relationship: part_of GO:0061684 ! chaperone-mediated autophagy + +[Term] +id: GO:1904764 +name: chaperone-mediated autophagy translocation complex disassembly +namespace: biological_process +def: "The disaggregation of a chaperone-mediated autophagy translocation complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18644871] +synonym: "chaperone-mediated autophagy receptor complex disassembly" RELATED [GOC:TermGenie] +synonym: "CMA receptor complex disassembly" RELATED [GOC:TermGenie] +synonym: "CMA translocation complex disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:1904765 +name: positive regulation of transcription from RNA polymerase II promoter in response to maltose +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus." [GO_REF:0000060, GOC:TermGenie, PMID:24224056] +synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" NARROW [GOC:TermGenie] +synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" RELATED [GOC:TermGenie] +synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus" EXACT [GOC:TermGenie] +is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +relationship: part_of GO:0071328 ! cellular response to maltose stimulus + +[Term] +id: GO:1904766 +name: negative regulation of macroautophagy by TORC1 signaling +namespace: biological_process +def: "A TORC1 signaling that results in negative regulation of macroautophagy." [GO_REF:0000063, GOC:autophagy, GOC:dph, GOC:TermGenie, PMID:23602450] +synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of autophagy in response to cellular starvation by TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of macroautophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of non-specific autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of non-specific autophagy by TORC1 signaling" EXACT [GOC:TermGenie] +synonym: "negative regulation of starvation-induced autophagy by TORC1 signal transduction" EXACT [GOC:TermGenie] +synonym: "negative regulation of starvation-induced autophagy by TORC1 signaling" EXACT [GOC:TermGenie] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:0038202 ! TORC1 signaling + +[Term] +id: GO:1904767 +name: octanoic acid binding +namespace: molecular_function +def: "Binding to octanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] +synonym: "caprylic acid binding" EXACT [CHEBI:28837] +is_a: GO:0005504 ! fatty acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:1904768 +name: all-trans-retinol binding +namespace: molecular_function +def: "Binding to all-trans-retinol." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] +is_a: GO:0019841 ! retinol binding + +[Term] +id: GO:1904769 +name: isopentadecanoic acid binding +namespace: molecular_function +def: "Binding to isopentadecanoic acid." [GO_REF:0000067, GOC:kmv, GOC:TermGenie, PMID:19828452] +synonym: "13-methylmyristic acid binding" EXACT [CHEBI:39250] +is_a: GO:0036041 ! long-chain fatty acid binding +is_a: GO:0043177 ! organic acid binding + +[Term] +id: GO:1904770 +name: intramembranous bone morphogenesis +namespace: biological_process +def: "The developmental process by which an intramembranous bone is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:26399686] +synonym: "intramembranous bones morphogenesis" RELATED [GOC:TermGenie] +synonym: "membrane bone morphogenesis" RELATED [GOC:TermGenie] +is_a: GO:0060349 ! bone morphogenesis + +[Term] +id: GO:1904771 +name: obsolete cellular response to doxorubicin +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:19801496] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1904772 +name: response to tetrachloromethane +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267] +synonym: "response to carbon tetrachloride" EXACT [] +synonym: "response to CCL4" EXACT [] +is_a: GO:0010033 ! response to organic substance + +[Term] +id: GO:1904773 +name: obsolete cellular response to tetrachloromethane +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetrachloromethane stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:7852267] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "cellular response to carbon tetrachloride" EXACT [] +synonym: "cellular response to CCL4" EXACT [] +is_obsolete: true + +[Term] +id: GO:1904774 +name: negative regulation of ubiquinone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303] +synonym: "down regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "down-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "down-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "downregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "downregulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of coenzyme Q biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquinone anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquinone biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquinone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquinone formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ubiquinone synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +relationship: negatively_regulates GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:1904775 +name: positive regulation of ubiquinone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ubiquinone biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:8125303] +synonym: "activation of coenzyme Q biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ubiquinone anabolism" NARROW [GOC:TermGenie] +synonym: "activation of ubiquinone biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of ubiquinone biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ubiquinone formation" NARROW [GOC:TermGenie] +synonym: "activation of ubiquinone synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme Q biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme Q biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of coenzyme Q10 biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q10 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q6 biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q6 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q8 biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q8 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q9 biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of coenzyme Q9 biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of ubiquinone anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquinone biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquinone biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquinone formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ubiquinone synthesis" EXACT [GOC:TermGenie] +is_a: GO:0010795 ! regulation of ubiquinone biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +relationship: positively_regulates GO:0006744 ! ubiquinone biosynthetic process + +[Term] +id: GO:1904776 +name: regulation of protein localization to cell cortex +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. +synonym: "regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +is_a: GO:1904375 ! regulation of protein localization to cell periphery +relationship: regulates GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:1904777 +name: negative regulation of protein localization to cell cortex +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. +synonym: "down regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to cell cortex" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to cell cortex" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +is_a: GO:1904376 ! negative regulation of protein localization to cell periphery +is_a: GO:1904776 ! regulation of protein localization to cell cortex +relationship: negatively_regulates GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:1904778 +name: positive regulation of protein localization to cell cortex +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. +synonym: "activation of protein localisation to cell cortex" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to cell cortex" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to cell cortex" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cell cortex" EXACT [GOC:TermGenie] +is_a: GO:1904377 ! positive regulation of protein localization to cell periphery +is_a: GO:1904776 ! regulation of protein localization to cell cortex +relationship: positively_regulates GO:0072697 ! protein localization to cell cortex + +[Term] +id: GO:1904779 +name: regulation of protein localization to centrosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). +synonym: "regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0071539 ! protein localization to centrosome + +[Term] +id: GO:1904780 +name: negative regulation of protein localization to centrosome +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). +synonym: "down regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to centrosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to centrosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to centrosome" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to centrosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to centrosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1904779 ! regulation of protein localization to centrosome +relationship: negatively_regulates GO:0071539 ! protein localization to centrosome + +[Term] +id: GO:1904781 +name: positive regulation of protein localization to centrosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to centrosome." [GO_REF:0000058, GOC:TermGenie, PMID:17115027] +comment: An example is cdk-2 in C. elegans (UniProt ID O61847) in PMID:17115027 (inferred from mutant phenotype). +synonym: "activation of protein localisation to centrosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to centrosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to centrosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to centrosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to centrosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to centrosome" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1904779 ! regulation of protein localization to centrosome +relationship: positively_regulates GO:0071539 ! protein localization to centrosome + +[Term] +id: GO:1904782 +name: negative regulation of NMDA glutamate receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] +synonym: "down regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "down-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "downregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "inhibition of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NMDA glutamate receptor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of NMDA receptor" NARROW [GOC:TermGenie] +synonym: "negative regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of NMDA receptor" EXACT [GOC:TermGenie] +is_a: GO:2000272 ! negative regulation of signaling receptor activity +is_a: GO:2000310 ! regulation of NMDA receptor activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1904783 +name: positive regulation of NMDA glutamate receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of NMDA glutamate receptor activity." [GO_REF:0000059, GOC:mr, GOC:TermGenie, PMID:12857] +synonym: "activation of N-methyl-D-aspartate selective glutamate receptor activity" NARROW [GOC:TermGenie] +synonym: "activation of NMDA glutamate receptor activity" NARROW [GOC:TermGenie] +synonym: "activation of NMDA receptor" NARROW [GOC:TermGenie] +synonym: "positive regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "up regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "up-regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of NMDA receptor" EXACT [GOC:TermGenie] +synonym: "upregulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NMDA glutamate receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of NMDA receptor" EXACT [GOC:TermGenie] +is_a: GO:2000273 ! positive regulation of signaling receptor activity +is_a: GO:2000310 ! regulation of NMDA receptor activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1904784 +name: NLRP1 inflammasome complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex." [GO_REF:0000079, GOC:TermGenie, PMID:19124602] +comment: The aggregation, arrangement and bonding together of a set of components to form the NLRP1 inflammasome complex, occurring at the level of an individual cell. +synonym: "NALP1 inflammasome complex assembly" EXACT [GOC:TermGenie] +synonym: "NALP1 inflammasome complex formation" EXACT [GOC:TermGenie] +synonym: "NLRP1 inflammasome complex formation" EXACT [GOC:TermGenie] +is_a: GO:0140632 ! inflammasome complex assembly + +[Term] +id: GO:1904785 +name: regulation of asymmetric protein localization involved in cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] +comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) +synonym: "regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:1905933 ! regulation of cell fate determination +relationship: regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination + +[Term] +id: GO:1904786 +name: negative regulation of asymmetric protein localization involved in cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] +comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) +synonym: "down regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "down regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "down regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "down-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "down-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "downregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "downregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "downregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "downregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "downregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "inhibition of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie] +synonym: "inhibition of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie] +synonym: "inhibition of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie] +synonym: "inhibition of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie] +synonym: "inhibition of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie] +synonym: "negative regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "negative regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "negative regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "negative regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination +relationship: negatively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination + +[Term] +id: GO:1904787 +name: positive regulation of asymmetric protein localization involved in cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of asymmetric protein localization involved in cell fate determination." [GO_REF:0000058, GOC:TermGenie, PMID:17476329] +comment: wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) +synonym: "activation of asymmetric protein localisation involved in cell fate determination" NARROW [GOC:TermGenie] +synonym: "activation of asymmetric protein localization involved in cell fate commitment" NARROW [GOC:TermGenie] +synonym: "activation of asymmetric protein localization involved in cell fate determination" NARROW [GOC:TermGenie] +synonym: "activation of asymmetric protein localization resulting in cell fate commitment" NARROW [GOC:TermGenie] +synonym: "activation of cell fate commitment, asymmetric protein localization" NARROW [GOC:TermGenie] +synonym: "positive regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "positive regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "positive regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "up regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "up regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "up regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "up-regulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up-regulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "up-regulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +synonym: "upregulation of asymmetric protein localisation involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "upregulation of asymmetric protein localization involved in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "upregulation of asymmetric protein localization involved in cell fate determination" EXACT [GOC:TermGenie] +synonym: "upregulation of asymmetric protein localization resulting in cell fate commitment" EXACT [GOC:TermGenie] +synonym: "upregulation of cell fate commitment, asymmetric protein localization" EXACT [GOC:TermGenie] +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1904785 ! regulation of asymmetric protein localization involved in cell fate determination +relationship: positively_regulates GO:0045167 ! asymmetric protein localization involved in cell fate determination + +[Term] +id: GO:1904788 +name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [GO_REF:0000063, GOC:TermGenie, PMID:22144909] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of induction of conjugation with cellular fusion by global transcription regulation from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of global transcription from Pol II promoter" RELATED [GOC:TermGenie] +synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter, global" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904789 +name: regulation of mitotic actomyosin contractile ring maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic actomyosin contractile ring maintenance." [GO_REF:0000058, GOC:TermGenie, PMID:24115772] +synonym: "regulation of contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "regulation of cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle" EXACT [GOC:TermGenie] +is_a: GO:0110020 ! regulation of actomyosin structure organization +is_a: GO:1903436 ! regulation of mitotic cytokinetic process +relationship: regulates GO:1902406 ! mitotic actomyosin contractile ring maintenance + +[Term] +id: GO:1904790 +name: regulation of shelterin complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] +synonym: "regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of telosome assembly" EXACT [] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0071573 ! shelterin complex assembly + +[Term] +id: GO:1904791 +name: negative regulation of shelterin complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] +synonym: "down regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of telosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of telosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of telosome assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of Pot1 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of shelterin complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of telosome assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of telosome assembly" EXACT [] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1904790 ! regulation of shelterin complex assembly +relationship: negatively_regulates GO:0071573 ! shelterin complex assembly + +[Term] +id: GO:1904792 +name: positive regulation of shelterin complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of shelterin complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:24270157] +synonym: "activation of Pot1 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Pot1-Tpz1 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of shelterin complex formation" NARROW [GOC:TermGenie] +synonym: "activation of telosome assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of telosome assembly" EXACT [] +synonym: "up regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of telosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of telosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Pot1 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Pot1-Tpz1 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of shelterin complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of telosome assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1904790 ! regulation of shelterin complex assembly +relationship: positively_regulates GO:0071573 ! shelterin complex assembly + +[Term] +id: GO:1904793 +name: regulation of euchromatin binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +is_a: GO:0035561 ! regulation of chromatin binding + +[Term] +id: GO:1904794 +name: negative regulation of euchromatin binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +synonym: "down regulation of euchromatin binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of euchromatin binding" EXACT [GOC:TermGenie] +synonym: "downregulation of euchromatin binding" EXACT [GOC:TermGenie] +synonym: "inhibition of euchromatin binding" NARROW [GOC:TermGenie] +is_a: GO:0035562 ! negative regulation of chromatin binding +is_a: GO:1904793 ! regulation of euchromatin binding + +[Term] +id: GO:1904795 +name: positive regulation of euchromatin binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of euchromatin binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +synonym: "activation of euchromatin binding" NARROW [GOC:TermGenie] +synonym: "up regulation of euchromatin binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of euchromatin binding" EXACT [GOC:TermGenie] +synonym: "upregulation of euchromatin binding" EXACT [GOC:TermGenie] +is_a: GO:0035563 ! positive regulation of chromatin binding +is_a: GO:1904793 ! regulation of euchromatin binding + +[Term] +id: GO:1904796 +name: regulation of core promoter binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1904797 +name: negative regulation of core promoter binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +synonym: "down regulation of core promoter binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of core promoter binding" EXACT [GOC:TermGenie] +synonym: "downregulation of core promoter binding" EXACT [GOC:TermGenie] +synonym: "inhibition of core promoter binding" NARROW [GOC:TermGenie] +is_a: GO:1904796 ! regulation of core promoter binding +is_a: GO:2000678 ! negative regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1904798 +name: positive regulation of core promoter binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of core promoter binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22723415] +synonym: "activation of core promoter binding" NARROW [GOC:TermGenie] +synonym: "up regulation of core promoter binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of core promoter binding" EXACT [GOC:TermGenie] +synonym: "upregulation of core promoter binding" EXACT [GOC:TermGenie] +is_a: GO:1904796 ! regulation of core promoter binding +is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1904799 +name: regulation of neuron remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] +comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) +synonym: "regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "regulation of neuronal remodeling" EXACT [GOC:TermGenie] +is_a: GO:0014041 ! regulation of neuron maturation +relationship: regulates GO:0016322 ! neuron remodeling + +[Term] +id: GO:1904800 +name: negative regulation of neuron remodeling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] +comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) +synonym: "down regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "down regulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "down regulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "down-regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "down-regulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "down-regulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "downregulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "downregulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "downregulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "inhibition of axon pruning" NARROW [GOC:TermGenie] +synonym: "inhibition of neuron remodeling" NARROW [GOC:TermGenie] +synonym: "inhibition of neuronal remodeling" NARROW [GOC:TermGenie] +synonym: "negative regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuronal remodeling" EXACT [GOC:TermGenie] +is_a: GO:0014043 ! negative regulation of neuron maturation +is_a: GO:1904799 ! regulation of neuron remodeling +relationship: negatively_regulates GO:0016322 ! neuron remodeling + +[Term] +id: GO:1904801 +name: positive regulation of neuron remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron remodeling." [GO_REF:0000058, GOC:TermGenie, PMID:21609829] +comment: cyy-1 in C. Elegans (P34624) in PMID:21609829 (inferred from mutant phenotype) +synonym: "activation of axon pruning" NARROW [GOC:TermGenie] +synonym: "activation of neuron remodeling" NARROW [GOC:TermGenie] +synonym: "activation of neuronal remodeling" NARROW [GOC:TermGenie] +synonym: "positive regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "positive regulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "up regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "up regulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "up regulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "up-regulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "up-regulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "up-regulation of neuronal remodeling" EXACT [GOC:TermGenie] +synonym: "upregulation of axon pruning" NARROW [GOC:TermGenie] +synonym: "upregulation of neuron remodeling" EXACT [GOC:TermGenie] +synonym: "upregulation of neuronal remodeling" EXACT [GOC:TermGenie] +is_a: GO:0014042 ! positive regulation of neuron maturation +is_a: GO:1904799 ! regulation of neuron remodeling +relationship: positively_regulates GO:0016322 ! neuron remodeling + +[Term] +id: GO:1904802 +name: RITS complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a RITS complex." [GO_REF:0000079, GOC:TermGenie, PMID:26443059] +synonym: "RITS complex formation" EXACT [GOC:TermGenie] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:1904803 +name: regulation of translation involved in cellular response to UV +namespace: biological_process +def: "Any regulation of translation that is involved in cellular response to UV." [GO_REF:0000060, GOC:TermGenie, PMID:17369398] +synonym: "regulation of protein anabolism involved in cellular response to UV" EXACT [GOC:TermGenie] +synonym: "regulation of protein biosynthesis involved in cellular response to UV" EXACT [GOC:TermGenie] +synonym: "regulation of protein formation involved in cellular response to UV" EXACT [GOC:TermGenie] +synonym: "regulation of protein synthesis involved in cellular response to UV" EXACT [GOC:TermGenie] +synonym: "regulation of translation involved in cellular response to ultraviolet light stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of translation involved in cellular response to ultraviolet radiation stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of translation involved in cellular response to UV light stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of translation involved in cellular response to UV radiation stimulus" EXACT [GOC:TermGenie] +is_a: GO:0006417 ! regulation of translation +relationship: part_of GO:0034644 ! cellular response to UV + +[Term] +id: GO:1904806 +name: regulation of protein oxidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] +synonym: "regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0018158 ! protein oxidation + +[Term] +id: GO:1904807 +name: negative regulation of protein oxidation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] +synonym: "down regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein oxidation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein oxidation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein oxidation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein amino acid oxidation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein oxidation" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:1904806 ! regulation of protein oxidation +relationship: negatively_regulates GO:0018158 ! protein oxidation + +[Term] +id: GO:1904808 +name: positive regulation of protein oxidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein oxidation." [GO_REF:0000058, GOC:TermGenie, PMID:22719267] +synonym: "activation of protein amino acid oxidation" NARROW [GOC:TermGenie] +synonym: "activation of protein oxidation" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "up regulation of protein oxidation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein oxidation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein amino acid oxidation" EXACT [GOC:TermGenie] +synonym: "upregulation of protein oxidation" EXACT [GOC:TermGenie] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:1904806 ! regulation of protein oxidation +relationship: positively_regulates GO:0018158 ! protein oxidation + +[Term] +id: GO:1904809 +name: regulation of dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: regulates GO:1901950 ! dense core granule transport + +[Term] +id: GO:1904810 +name: negative regulation of dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie] +synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903650 ! negative regulation of cytoplasmic transport +is_a: GO:1904809 ! regulation of dense core granule transport +relationship: negatively_regulates GO:1901950 ! dense core granule transport + +[Term] +id: GO:1904811 +name: positive regulation of dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie] +synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903651 ! positive regulation of cytoplasmic transport +is_a: GO:1904809 ! regulation of dense core granule transport +relationship: positively_regulates GO:1901950 ! dense core granule transport + +[Term] +id: GO:1904812 +name: rRNA acetylation involved in maturation of SSU-rRNA +namespace: biological_process +def: "Any rRNA acetylation that is involved in maturation of SSU-rRNA." [GO_REF:0000060, GOC:TermGenie, PMID:25402480] +synonym: "rRNA acetylation involved in processing of 20S pre-rRNA" NARROW [GOC:TermGenie] +synonym: "rRNA acetylation involved in SSU-rRNA maturation" EXACT [GOC:TermGenie] +is_a: GO:1990882 ! rRNA acetylation +relationship: part_of GO:0030490 ! maturation of SSU-rRNA + +[Term] +id: GO:1904813 +name: ficolin-1-rich granule lumen +namespace: cellular_component +def: "Any membrane-enclosed lumen that is part of a ficolin-1-rich granule." [GO_REF:0000064, GOC:TermGenie, PMID:23650620] +synonym: "ficolin-1-rich granule membrane-enclosed lumen" EXACT [] +synonym: "membrane-enclosed lumen of ficolin granule" RELATED [GOC:TermGenie] +synonym: "membrane-enclosed lumen of ficolin-1 rich granule" EXACT [GOC:TermGenie] +synonym: "membrane-enclosed lumen of ficolin-1-rich granule" EXACT [GOC:TermGenie] +is_a: GO:0070013 ! intracellular organelle lumen +relationship: part_of GO:0101002 ! ficolin-1-rich granule + +[Term] +id: GO:1904814 +name: regulation of protein localization to chromosome, telomeric region +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] +synonym: "regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0070198 ! protein localization to chromosome, telomeric region + +[Term] +id: GO:1904815 +name: negative regulation of protein localization to chromosome, telomeric region +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] +synonym: "down regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to telomere" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region +relationship: negatively_regulates GO:0070198 ! protein localization to chromosome, telomeric region + +[Term] +id: GO:1904816 +name: positive regulation of protein localization to chromosome, telomeric region +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19487455] +synonym: "activation of protein localisation to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to telomere" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1904814 ! regulation of protein localization to chromosome, telomeric region +relationship: positively_regulates GO:0070198 ! protein localization to chromosome, telomeric region + +[Term] +id: GO:1904817 +name: serous membrane development +namespace: biological_process +def: "The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] +synonym: "serosa development" RELATED [GOC:TermGenie] +synonym: "tunica serosa development" EXACT [GOC:TermGenie] +synonym: "wall of serous sac development" EXACT [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1904818 +name: visceral peritoneum development +namespace: biological_process +def: "The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:1904820 ! peritoneum development + +[Term] +id: GO:1904819 +name: parietal peritoneum development +namespace: biological_process +def: "The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] +synonym: "peritoneal cavity lining development" EXACT [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:1904820 ! peritoneum development + +[Term] +id: GO:1904820 +name: peritoneum development +namespace: biological_process +def: "The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure." [GO_REF:0000094, GOC:dph, GOC:TermGenie, PMID:15840053] +synonym: "peritonaeum development" RELATED [GOC:TermGenie] +is_a: GO:1904817 ! serous membrane development + +[Term] +id: GO:1904821 +name: chloroplast disassembly +namespace: biological_process +def: "The disaggregation of a chloroplast into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:26494759] +comment: The disaggregation of a chloroplast into its constituent components. +synonym: "chloroplast degradation" RELATED [PMID:26494759] +is_a: GO:0009658 ! chloroplast organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1904823 +name: purine nucleobase transmembrane transport +namespace: biological_process +def: "The process in which a purine nucleobase is transported across a membrane." [GO_REF:0000069, GOC:TermGenie] +is_a: GO:0006863 ! purine nucleobase transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport + +[Term] +id: GO:1904824 +name: anaphase-promoting complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an anaphase-promoting complex." [GO_REF:0000079, GOC:TermGenie, PMID:16950791] +synonym: "anaphase promoting complex assembly" EXACT [GOC:TermGenie] +synonym: "anaphase promoting complex formation" EXACT [GOC:TermGenie] +synonym: "anaphase-promoting complex formation" EXACT [GOC:TermGenie] +synonym: "APC assembly" BROAD [] +synonym: "cyclosome assembly" EXACT [GOC:TermGenie] +synonym: "cyclosome formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904825 +name: protein localization to microtubule plus-end +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at a microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:24039245] +synonym: "protein localisation to microtubule plus-end" EXACT [GOC:TermGenie] +is_a: GO:1905725 ! protein localization to microtubule end + +[Term] +id: GO:1904826 +name: regulation of hydrogen sulfide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +synonym: "regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +relationship: regulates GO:0070814 ! hydrogen sulfide biosynthetic process + +[Term] +id: GO:1904827 +name: negative regulation of hydrogen sulfide biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +synonym: "down regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "inhibition of hydrogen sulfide anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulfide formation" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulfide synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process +relationship: negatively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process + +[Term] +id: GO:1904828 +name: positive regulation of hydrogen sulfide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hydrogen sulfide biosynthetic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +synonym: "activation of hydrogen sulfide anabolism" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulfide biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulfide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulfide formation" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulfide synthesis" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulphide biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen sulphide biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulfide anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulfide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulfide biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulfide formation" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulfide synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulphide biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen sulphide biosynthetic process" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1904826 ! regulation of hydrogen sulfide biosynthetic process +relationship: positively_regulates GO:0070814 ! hydrogen sulfide biosynthetic process + +[Term] +id: GO:1904829 +name: regulation of aortic smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation +relationship: regulates GO:0035887 ! aortic smooth muscle cell differentiation + +[Term] +id: GO:1904830 +name: negative regulation of aortic smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +synonym: "down regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation +relationship: negatively_regulates GO:0035887 ! aortic smooth muscle cell differentiation + +[Term] +id: GO:1904831 +name: positive regulation of aortic smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22034194] +synonym: "activation of aortic smooth muscle cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of aortic smooth muscle cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1904829 ! regulation of aortic smooth muscle cell differentiation +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation +relationship: positively_regulates GO:0035887 ! aortic smooth muscle cell differentiation + +[Term] +id: GO:1904832 +name: negative regulation of removal of superoxide radicals +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756] +synonym: "down regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "down regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "down regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "down regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "down-regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "down-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "down-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "downregulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "downregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "downregulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie] +synonym: "inhibition of removal of O2-" NARROW [GOC:TermGenie] +synonym: "inhibition of removal of oxygen free radicals" NARROW [GOC:TermGenie] +synonym: "inhibition of removal of superoxide radicals" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "negative regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "negative regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +is_a: GO:1900408 ! negative regulation of cellular response to oxidative stress +is_a: GO:1901032 ! negative regulation of response to reactive oxygen species +is_a: GO:2000121 ! regulation of removal of superoxide radicals +is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process +relationship: negatively_regulates GO:0019430 ! removal of superoxide radicals + +[Term] +id: GO:1904833 +name: positive regulation of removal of superoxide radicals +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of removal of superoxide radicals." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22836756] +synonym: "activation of cellular detoxification of superoxide radicals" NARROW [GOC:TermGenie] +synonym: "activation of removal of O2-" NARROW [GOC:TermGenie] +synonym: "activation of removal of oxygen free radicals" NARROW [GOC:TermGenie] +synonym: "activation of removal of superoxide radicals" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "positive regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "positive regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "up regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "up regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "up regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "up-regulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "up-regulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "up-regulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular detoxification of superoxide radicals" EXACT [GOC:TermGenie] +synonym: "upregulation of removal of O2-" EXACT [GOC:TermGenie] +synonym: "upregulation of removal of oxygen free radicals" EXACT [GOC:TermGenie] +synonym: "upregulation of removal of superoxide radicals" EXACT [GOC:TermGenie] +is_a: GO:2000121 ! regulation of removal of superoxide radicals +is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process +relationship: positively_regulates GO:0019430 ! removal of superoxide radicals + +[Term] +id: GO:1904835 +name: dorsal root ganglion morphogenesis +namespace: biological_process +def: "The developmental process by which a dorsal root ganglion is generated and organized." [GO_REF:0000083, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] +synonym: "dorsal root ganglia morphogenesis" RELATED [GOC:TermGenie] +synonym: "DRG morphogenesis" RELATED [GOC:TermGenie] +synonym: "ganglion of dorsal root morphogenesis" EXACT [GOC:TermGenie] +synonym: "ganglion sensorium nervi spinalis morphogenesis" RELATED [GOC:TermGenie] +synonym: "ganglion spinale morphogenesis" RELATED [GOC:TermGenie] +synonym: "ganglion spinalis morphogenesis" EXACT [GOC:TermGenie] +synonym: "posterior root ganglion morphogenesis" RELATED [GOC:TermGenie] +synonym: "spinal ganglion morphogenesis" EXACT [GOC:TermGenie] +synonym: "spinal ganglion part of peripheral nervous system morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0061552 ! ganglion morphogenesis +relationship: part_of GO:1990791 ! dorsal root ganglion development + +[Term] +id: GO:1904836 +name: facioacoustic ganglion morphogenesis +namespace: biological_process +def: "The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized." [GO_REF:0000083, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] +synonym: "acoustico-facial VII-VIII ganglion complex morphogenesis" EXACT [UBERON:0012175] +synonym: "acousticofacial ganglion morphogenesis" EXACT [GOC:TermGenie] +synonym: "facio-acoustic ganglion complex morphogenesis" RELATED [GOC:TermGenie] +synonym: "facio-acoustic ganglion complex VII-VIII morphogenesis" EXACT [GOC:TermGenie] +synonym: "facio-acoustic ganglion morphogenesis" EXACT [GOC:TermGenie] +synonym: "facio-acoustic VII-VIII ganglion complex morphogenesis" RELATED [GOC:TermGenie] +is_a: GO:0061559 ! cranial ganglion morphogenesis +relationship: part_of GO:1903375 ! facioacoustic ganglion development + +[Term] +id: GO:1904837 +name: beta-catenin-TCF complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] +synonym: "beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904838 +name: regulation of male germ-line stem cell asymmetric division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] +synonym: "regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:0009786 ! regulation of asymmetric cell division +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000035 ! regulation of stem cell division +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048133 ! male germ-line stem cell asymmetric division + +[Term] +id: GO:1904839 +name: negative regulation of male germ-line stem cell asymmetric division +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] +synonym: "down regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "down regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "down-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "down-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "downregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "downregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "inhibition of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] +synonym: "inhibition of male germ-line stem cell renewal" NARROW [GOC:TermGenie] +synonym: "negative regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0045769 ! negative regulation of asymmetric cell division +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048133 ! male germ-line stem cell asymmetric division + +[Term] +id: GO:1904840 +name: positive regulation of male germ-line stem cell asymmetric division +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division." [GO_REF:0000058, GOC:TermGenie, PMID:19339709] +synonym: "activation of male germ-line stem cell asymmetric division" NARROW [GOC:TermGenie] +synonym: "activation of male germ-line stem cell renewal" NARROW [GOC:TermGenie] +synonym: "positive regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "up regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "up regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "up-regulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "up-regulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +synonym: "upregulation of male germ-line stem cell asymmetric division" EXACT [GOC:TermGenie] +synonym: "upregulation of male germ-line stem cell renewal" EXACT [GOC:TermGenie] +is_a: GO:0045770 ! positive regulation of asymmetric cell division +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1904838 ! regulation of male germ-line stem cell asymmetric division +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048133 ! male germ-line stem cell asymmetric division + +[Term] +id: GO:1904841 +name: TORC2 complex binding +namespace: molecular_function +def: "Binding to a TORC2 complex." [GOC:TermGenie, PMID:20660630] +comment: Binding to a TORC2 complex, a protein complex that mediates the phosphorylation of protein kinase B +synonym: "mTORC2 binding" NARROW [GOC:TermGenie] +synonym: "rapamycin and nutrient-insensitive TOR complex binding" EXACT [GOC:TermGenie] +synonym: "TOR complex 2 binding" EXACT [GOC:TermGenie] +synonym: "TORC 2 complex binding" EXACT [GOC:TermGenie] +synonym: "TORC2 binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904842 +name: response to nitroglycerin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975] +synonym: "response to nitroglycerine" EXACT [] +synonym: "response to nitroglycerol" EXACT [] +synonym: "response to trinitroglycerin" EXACT [] +synonym: "response to trinitroglycerol" EXACT [] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1904843 +name: cellular response to nitroglycerin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25626975] +synonym: "cellular response to nitroglycerine" EXACT [] +synonym: "cellular response to nitroglycerol" EXACT [] +synonym: "cellular response to trinitroglycerin" EXACT [] +synonym: "cellular response to trinitroglycerol" EXACT [] +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1904842 ! response to nitroglycerin + +[Term] +id: GO:1904844 +name: response to L-glutamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1904845 +name: cellular response to L-glutamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23185570] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1904844 ! response to L-glutamine + +[Term] +id: GO:1904846 +name: negative regulation of establishment of bipolar cell polarity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of bipolar cell polarity." [GO_REF:0000058, GOC:TermGenie, PMID:26525038] +synonym: "down regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of bipolar cell polarity" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of bipolar cell polarity" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0061172 ! regulation of establishment of bipolar cell polarity +relationship: negatively_regulates GO:0061171 ! establishment of bipolar cell polarity + +[Term] +id: GO:1904847 +name: regulation of cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0050920 ! regulation of chemotaxis +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:1904848 +name: negative regulation of cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] +synonym: "down regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +synonym: "downregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +synonym: "inhibition of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor +relationship: negatively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:1904849 +name: positive regulation of cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell chemotaxis to fibroblast growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23233752] +synonym: "activation of cell chemotaxis to fibroblast growth factor" NARROW [GOC:TermGenie] +synonym: "up regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +synonym: "upregulation of cell chemotaxis to fibroblast growth factor" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor +relationship: positively_regulates GO:0035766 ! cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:1904850 +name: negative regulation of establishment of protein localization to telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "down regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of protein localisation to telomere" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of protein localization to telomere" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +is_a: GO:0070203 ! regulation of establishment of protein localization to telomere +is_a: GO:1904815 ! negative regulation of protein localization to chromosome, telomeric region +is_a: GO:1904950 ! negative regulation of establishment of protein localization +relationship: negatively_regulates GO:0070200 ! establishment of protein localization to telomere + +[Term] +id: GO:1904851 +name: positive regulation of establishment of protein localization to telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "activation of establishment of protein localisation to telomere" NARROW [GOC:TermGenie] +synonym: "activation of establishment of protein localization to chromosome, telomeric region" NARROW [GOC:TermGenie] +synonym: "activation of establishment of protein localization to telomere" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localisation to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localization to chromosome, telomeric region" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0070203 ! regulation of establishment of protein localization to telomere +is_a: GO:1904816 ! positive regulation of protein localization to chromosome, telomeric region +is_a: GO:1904951 ! positive regulation of establishment of protein localization +relationship: positively_regulates GO:0070200 ! establishment of protein localization to telomere + +[Term] +id: GO:1904852 +name: trimethylamine-N-oxide reductase (cytochrome c) complex +namespace: cellular_component +def: "A protein complex which is capable of trimethylamine-N-oxide reductase (cytochrome c) activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:11056172] +comment: An example of this is TorA in E. coli (UniProt ID P33225) in PMID:11056172 (inferred from direct assay). +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1904853 +name: protein localization to ascospore wall +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an ascospore wall." [GO_REF:0000087, GOC:TermGenie, PMID:24623719] +synonym: "protein localisation in ascospore wall" EXACT [GOC:TermGenie] +synonym: "protein localisation to ascospore wall" EXACT [GOC:TermGenie] +synonym: "protein localization in ascospore wall" EXACT [GOC:TermGenie] +is_a: GO:0099614 ! protein localization to spore cell wall + +[Term] +id: GO:1904854 +name: proteasome core complex binding +namespace: molecular_function +def: "Binding to a proteasome core complex." [GOC:TermGenie, PMID:16096059] +synonym: "20S core complex binding" NARROW [GOC:TermGenie] +synonym: "20S proteasome binding" NARROW [GOC:TermGenie] +synonym: "macropain binding" EXACT [GOC:TermGenie] +synonym: "PA28gamma-20S proteasome binding" NARROW [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904855 +name: proteasome regulatory particle binding +namespace: molecular_function +def: "Binding to a proteasome regulatory particle." [GOC:TermGenie, PMID:16096059] +synonym: "19S regulatory particle binding" NARROW [GOC:TermGenie] +synonym: "modulator complex binding" RELATED [GOC:TermGenie] +synonym: "PA700 proteasome activator binding" NARROW [GOC:TermGenie] +synonym: "PA700-dependent proteasome activator binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904856 +name: cytolytic granule lumen +namespace: cellular_component +def: "Any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule." [GO_REF:0000064, GOC:TermGenie, PMID:17272266, PMID:21247065] +synonym: "cytolytic granule cytoplasmic membrane-bounded vesicle lumen" EXACT [] +synonym: "cytoplasmic membrane-bounded vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie] +synonym: "cytoplasmic membrane-enclosed vesicle lumen of cytolytic granule" EXACT [GOC:TermGenie] +is_a: GO:0005775 ! vacuolar lumen +is_a: GO:0060205 ! cytoplasmic vesicle lumen +relationship: part_of GO:0044194 ! cytolytic granule + +[Term] +id: GO:1904857 +name: regulation of endothelial cell chemotaxis to vascular endothelial growth factor +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0050920 ! regulation of chemotaxis +is_a: GO:1902547 ! regulation of cellular response to vascular endothelial growth factor stimulus +relationship: regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor + +[Term] +id: GO:1904858 +name: negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] +synonym: "down regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "inhibition of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:1902548 ! negative regulation of cellular response to vascular endothelial growth factor stimulus +is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor +relationship: negatively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor + +[Term] +id: GO:1904859 +name: positive regulation of endothelial cell chemotaxis to vascular endothelial growth factor +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:21885851] +synonym: "activation of endothelial cell chemotaxis to vascular endothelial growth factor" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelial cell chemotaxis to vascular endothelial growth factor" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1904857 ! regulation of endothelial cell chemotaxis to vascular endothelial growth factor +relationship: positively_regulates GO:0090668 ! endothelial cell chemotaxis to vascular endothelial growth factor + +[Term] +id: GO:1904860 +name: DNA synthesis involved in mitotic DNA replication +namespace: biological_process +def: "Any DNA biosynthetic process that is involved in mitotic DNA replication." [GO_REF:0000060, GOC:TermGenie, PMID:16849602] +synonym: "DNA anabolism involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA anabolism involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA anabolism involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA anabolism involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA anabolism involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA anabolism involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA anabolism involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA biosynthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA biosynthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA biosynthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA biosynthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA biosynthesis involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA biosynthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA biosynthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in mitotic DNA replication" EXACT [] +synonym: "DNA biosynthetic process involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA biosynthetic process involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA formation involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA formation involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA formation involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA formation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA formation involved in mitotic DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA formation involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA formation involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA synthesis involved in DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] +synonym: "DNA synthesis involved in DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] +synonym: "DNA synthesis involved in nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] +is_a: GO:0090592 ! DNA synthesis involved in DNA replication +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1904861 +name: excitatory synapse assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] +synonym: "excitatory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0007416 ! synapse assembly + +[Term] +id: GO:1904862 +name: inhibitory synapse assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "inhibitory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0007416 ! synapse assembly + +[Term] +id: GO:1904863 +name: regulation of beta-catenin-TCF complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1904837 ! beta-catenin-TCF complex assembly + +[Term] +id: GO:1904864 +name: negative regulation of beta-catenin-TCF complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18936100] +synonym: "down regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "down regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "downregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "downregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "inhibition of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "inhibition of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly +relationship: negatively_regulates GO:1904837 ! beta-catenin-TCF complex assembly + +[Term] +id: GO:1904865 +name: positive regulation of beta-catenin-TCF complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of beta-catenin-TCF complex assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of beta-catenin-TCF complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of beta-catenin-TCF complex formation" NARROW [GOC:TermGenie] +synonym: "activation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "activation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "activation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "activation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "up regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "up regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +synonym: "upregulation of beta-catenin-TCF complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-catenin-TCF complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-catenin/LEF complex assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of beta-catenin/LEF complex formation" NARROW [GOC:TermGenie] +synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of beta-catenin/lymphoid enhancer binding factor complex formation" RELATED [GOC:TermGenie] +synonym: "upregulation of beta-catenin/T-cell factor complex assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of beta-catenin/T-cell factor complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1904863 ! regulation of beta-catenin-TCF complex assembly +relationship: positively_regulates GO:1904837 ! beta-catenin-TCF complex assembly + +[Term] +id: GO:1904866 +name: ventral tegmental area development +namespace: biological_process +def: "The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26548362] +synonym: "a10a development" EXACT [GOC:TermGenie] +synonym: "area tegmentalis ventralis (Tsai) development" RELATED [GOC:TermGenie] +synonym: "area tegmentalis ventralis development" RELATED [GOC:TermGenie] +synonym: "tegmentum ventrale development" RELATED [GOC:TermGenie] +synonym: "ventral brain stem development" RELATED [GOC:TermGenie] +synonym: "ventral tegmental area (Tsai) development" RELATED [GOC:TermGenie] +synonym: "ventral tegmental area of tsai development" EXACT [GOC:TermGenie] +synonym: "ventral tegmental nucleus (Rioch) development" RELATED [GOC:TermGenie] +synonym: "ventral tegmental nucleus (tsai) development" EXACT [GOC:TermGenie] +synonym: "ventral tegmental nucleus of tsai development" EXACT [GOC:TermGenie] +synonym: "ventral tegmentum development" EXACT [Wikipedia:Ventral_tegmental_area] +synonym: "ventromedial mesencephalic tegmentum development" RELATED [GOC:TermGenie] +synonym: "VTA development" BROAD [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:1904867 +name: protein localization to Cajal body +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a Cajal body." [GO_REF:0000087, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "protein localization in Cajal body" EXACT [GOC:TermGenie] +is_a: GO:1903405 ! protein localization to nuclear body + +[Term] +id: GO:1904868 +name: telomerase catalytic core complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase catalytic core complex." [GO_REF:0000079, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "TERT-TERC complex formation" RELATED [GOC:TermGenie] +is_a: GO:1905323 ! telomerase holoenzyme complex assembly + +[Term] +id: GO:1904869 +name: regulation of protein localization to Cajal body +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +is_a: GO:1900180 ! regulation of protein localization to nucleus +relationship: regulates GO:1904867 ! protein localization to Cajal body + +[Term] +id: GO:1904870 +name: negative regulation of protein localization to Cajal body +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "down regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in Cajal body" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to Cajal body" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in Cajal body" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to Cajal body" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +is_a: GO:1900181 ! negative regulation of protein localization to nucleus +is_a: GO:1904869 ! regulation of protein localization to Cajal body +relationship: negatively_regulates GO:1904867 ! protein localization to Cajal body + +[Term] +id: GO:1904871 +name: positive regulation of protein localization to Cajal body +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "activation of protein localisation in Cajal body" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to Cajal body" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in Cajal body" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to Cajal body" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in Cajal body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to Cajal body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in Cajal body" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to Cajal body" EXACT [GOC:TermGenie] +is_a: GO:1900182 ! positive regulation of protein localization to nucleus +is_a: GO:1904869 ! regulation of protein localization to Cajal body +relationship: positively_regulates GO:1904867 ! protein localization to Cajal body + +[Term] +id: GO:1904872 +name: regulation of telomerase RNA localization to Cajal body +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0090671 ! telomerase RNA localization to Cajal body + +[Term] +id: GO:1904873 +name: negative regulation of telomerase RNA localization to Cajal body +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "down regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "downregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "inhibition of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body +relationship: negatively_regulates GO:0090671 ! telomerase RNA localization to Cajal body + +[Term] +id: GO:1904874 +name: positive regulation of telomerase RNA localization to Cajal body +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444] +synonym: "activation of telomerase RNA localization to Cajal body" NARROW [GOC:TermGenie] +synonym: "up regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +synonym: "upregulation of telomerase RNA localization to Cajal body" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1904872 ! regulation of telomerase RNA localization to Cajal body +relationship: positively_regulates GO:0090671 ! telomerase RNA localization to Cajal body + +[Term] +id: GO:1904875 +name: regulation of DNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] +is_a: GO:0051105 ! regulation of DNA ligation +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:1904876 +name: negative regulation of DNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] +synonym: "down regulation of DNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA ligase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA ligase activity" NARROW [GOC:TermGenie] +is_a: GO:0051107 ! negative regulation of DNA ligation +is_a: GO:0051352 ! negative regulation of ligase activity +is_a: GO:1904875 ! regulation of DNA ligase activity + +[Term] +id: GO:1904877 +name: positive regulation of DNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA ligase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:TermGenie, PMID:17389648] +synonym: "activation of DNA ligase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA ligase activity" EXACT [GOC:TermGenie] +is_a: GO:0051106 ! positive regulation of DNA ligation +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:1904875 ! regulation of DNA ligase activity + +[Term] +id: GO:1904878 +name: negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515] +synonym: "down regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +synonym: "down-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +synonym: "downregulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +synonym: "inhibition of generation of L-type calcium current" NARROW [GOC:TermGenie] +synonym: "negative regulation of generation of L-type calcium current" RELATED [] +is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +relationship: negatively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel + +[Term] +id: GO:1904879 +name: positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transport via high voltage-gated calcium channel." [GO_REF:0000058, GOC:TermGenie, PMID:23071515] +synonym: "activation of generation of L-type calcium current" NARROW [GOC:TermGenie] +synonym: "positive regulation of generation of L-type calcium current" RELATED [] +synonym: "up regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +synonym: "up-regulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +synonym: "upregulation of generation of L-type calcium current" EXACT [GOC:TermGenie] +is_a: GO:1902514 ! regulation of calcium ion transmembrane transport via high voltage-gated calcium channel +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +relationship: positively_regulates GO:0061577 ! calcium ion transmembrane transport via high voltage-gated calcium channel + +[Term] +id: GO:1904880 +name: response to hydrogen sulfide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] +synonym: "response to dihydridosulfur" EXACT [] +synonym: "response to sulfane" EXACT [] +is_a: GO:0010035 ! response to inorganic substance + +[Term] +id: GO:1904881 +name: cellular response to hydrogen sulfide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen sulfide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24012591] +synonym: "cellular response to dihydridosulfur" EXACT [] +synonym: "cellular response to sulfane" EXACT [] +is_a: GO:0070887 ! cellular response to chemical stimulus +is_a: GO:1904880 ! response to hydrogen sulfide + +[Term] +id: GO:1904882 +name: regulation of telomerase catalytic core complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1904868 ! telomerase catalytic core complex assembly + +[Term] +id: GO:1904883 +name: negative regulation of telomerase catalytic core complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "down regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "downregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "inhibition of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of telomerase catalytic core complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly +relationship: negatively_regulates GO:1904868 ! telomerase catalytic core complex assembly + +[Term] +id: GO:1904884 +name: positive regulation of telomerase catalytic core complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomerase catalytic core complex assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "activation of telomerase catalytic core complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of telomerase catalytic core complex formation" NARROW [GOC:TermGenie] +synonym: "activation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "activation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "up regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +synonym: "upregulation of telomerase catalytic core complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of telomerase catalytic core complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of TERT-TERC complex assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of TERT-TERC complex formation" RELATED [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1904882 ! regulation of telomerase catalytic core complex assembly +relationship: positively_regulates GO:1904868 ! telomerase catalytic core complex assembly + +[Term] +id: GO:1904885 +name: beta-catenin destruction complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a beta-catenin destruction complex." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17143292, PMID:23169527] +synonym: "23S APC complex assembly" NARROW [GOC:TermGenie] +synonym: "23S APC complex formation" NARROW [GOC:TermGenie] +synonym: "APC-Axin-1-beta-catenin complex assembly" EXACT [GOC:TermGenie] +synonym: "APC-Axin-1-beta-catenin complex formation" EXACT [GOC:TermGenie] +synonym: "Axin-APC-beta-catenin-GSK3B complex assembly" EXACT [GOC:TermGenie] +synonym: "Axin-APC-beta-catenin-GSK3B complex formation" EXACT [GOC:TermGenie] +synonym: "BDC assembly" EXACT [GOC:TermGenie] +synonym: "BDC formation" EXACT [GOC:TermGenie] +synonym: "beta-catenin degradation complex assembly" EXACT [GOC:TermGenie] +synonym: "beta-catenin degradation complex formation" EXACT [GOC:TermGenie] +synonym: "beta-catenin destruction complex formation" EXACT [GOC:TermGenie] +synonym: "destruction complex formation" RELATED [PMID:23169527] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904886 +name: beta-catenin destruction complex disassembly +namespace: biological_process +def: "The disaggregation of a beta-catenin destruction complex into its constituent components." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23169527] +synonym: "23S APC complex disassembly" NARROW [GOC:TermGenie] +synonym: "APC-Axin-1-beta-catenin complex disassembly" EXACT [GOC:TermGenie] +synonym: "Axin-APC-beta-catenin-GSK3B complex disassembly" EXACT [GOC:TermGenie] +synonym: "BDC disassembly" EXACT [GOC:TermGenie] +synonym: "beta-catenin degradation complex disassembly" EXACT [GOC:TermGenie] +synonym: "dissociation of beta-catenin degradation complex" EXACT [GOC:bf, PMID:17318175] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:1904887 +name: Wnt signalosome assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a Wnt signalosome." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22899650] +synonym: "LRP5/6 signalosome assembly" EXACT [GOC:TermGenie] +synonym: "LRP5/6 signalosome formation" EXACT [GOC:TermGenie] +synonym: "LRP6 signalosome assembly" NARROW [GOC:TermGenie] +synonym: "LRP6 signalosome formation" NARROW [GOC:TermGenie] +synonym: "Wnt signalosome complex assembly" EXACT [GOC:TermGenie] +synonym: "Wnt signalosome complex formation" EXACT [GOC:TermGenie] +synonym: "Wnt signalosome formation" EXACT [GOC:TermGenie] +synonym: "Wnt-LRP5/6 signalosome assembly" EXACT [GOC:TermGenie] +synonym: "Wnt-LRP5/6 signalosome formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904888 +name: cranial skeletal system development +namespace: biological_process +def: "The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus." [GO_REF:0000094, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11262227] +synonym: "cranial skeleton development" NARROW [GOC:TermGenie] +synonym: "craniofacial development" NARROW [PMID:11262227] +synonym: "cranium development" RELATED [GOC:TermGenie] +synonym: "osteocranium development" NARROW [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1904889 +name: regulation of excitatory synapse assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051963 ! regulation of synapse assembly +relationship: regulates GO:1904861 ! excitatory synapse assembly + +[Term] +id: GO:1904890 +name: negative regulation of excitatory synapse assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "downregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "inhibition of excitatory synapse assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of excitatory synapse formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051964 ! negative regulation of synapse assembly +is_a: GO:1904889 ! regulation of excitatory synapse assembly +relationship: negatively_regulates GO:1904861 ! excitatory synapse assembly + +[Term] +id: GO:1904891 +name: positive regulation of excitatory synapse assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of excitatory synapse assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21670302] +synonym: "activation of excitatory synapse assembly" NARROW [GOC:TermGenie] +synonym: "activation of excitatory synapse formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "up regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of excitatory synapse formation" EXACT [GOC:TermGenie] +synonym: "upregulation of excitatory synapse assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of excitatory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051965 ! positive regulation of synapse assembly +is_a: GO:1904889 ! regulation of excitatory synapse assembly +relationship: positively_regulates GO:1904861 ! excitatory synapse assembly + +[Term] +id: GO:1904892 +name: regulation of receptor signaling pathway via STAT +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] +synonym: "regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0097696 ! receptor signaling pathway via STAT + +[Term] +id: GO:1904893 +name: negative regulation of receptor signaling pathway via STAT +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor signaling via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] +synonym: "down regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of kinase activated-STAT cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of kinase-STAT cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of STAT cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of STAT signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "negative regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT +relationship: negatively_regulates GO:0097696 ! receptor signaling pathway via STAT + +[Term] +id: GO:1904894 +name: positive regulation of receptor signaling pathway via STAT +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT." [GO_REF:0000058, GOC:rjd, GOC:TermGenie, PMID:24587195] +synonym: "activation of kinase activated-STAT cascade" NARROW [GOC:TermGenie] +synonym: "activation of kinase-STAT cascade" NARROW [GOC:TermGenie] +synonym: "activation of STAT cascade" NARROW [GOC:TermGenie] +synonym: "activation of STAT signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "positive regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "positive regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of STAT signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of kinase activated-STAT cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of kinase-STAT cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of STAT cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of STAT signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1904892 ! regulation of receptor signaling pathway via STAT +relationship: positively_regulates GO:0097696 ! receptor signaling pathway via STAT + +[Term] +id: GO:1904895 +name: ESCRT complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109] +synonym: "endosomal sorting complex required for transport assembly" EXACT [GOC:TermGenie] +synonym: "endosomal sorting complex required for transport formation" EXACT [GOC:TermGenie] +synonym: "ESCRT complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1904896 +name: ESCRT complex disassembly +namespace: biological_process +def: "The disaggregation of an ESCRT complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:21118109] +synonym: "endosomal sorting complex required for transport disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:1904897 +name: regulation of hepatic stellate cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] +synonym: "regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: regulates GO:1990922 ! hepatic stellate cell proliferation + +[Term] +id: GO:1904898 +name: negative regulation of hepatic stellate cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] +synonym: "down regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "down regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of Ito cell proliferation" NARROW [GOC:TermGenie] +synonym: "inhibition of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] +synonym: "negative regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "negative regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048147 ! negative regulation of fibroblast proliferation +is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation +relationship: negatively_regulates GO:1990922 ! hepatic stellate cell proliferation + +[Term] +id: GO:1904899 +name: positive regulation of hepatic stellate cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15358192] +synonym: "activation of hepatic perisinusoidal cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of hepatic stellate cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of Ito cell proliferation" NARROW [GOC:TermGenie] +synonym: "activation of perisinusoidal cell proliferation" NARROW [GOC:TermGenie] +synonym: "positive regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "positive regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "up regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatic perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of hepatic stellate cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of Ito cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of perisinusoidal cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0048146 ! positive regulation of fibroblast proliferation +is_a: GO:1904897 ! regulation of hepatic stellate cell proliferation +relationship: positively_regulates GO:1990922 ! hepatic stellate cell proliferation + +[Term] +id: GO:1904900 +name: negative regulation of myosin II filament organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] +synonym: "down regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "down regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "down regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "down-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "downregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "downregulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "downregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "inhibition of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "inhibition of myosin II filament organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of myosin II filament organization" NARROW [GOC:TermGenie] +synonym: "inhibition of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "negative regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +is_a: GO:0043519 ! regulation of myosin II filament organization +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +relationship: negatively_regulates GO:0031038 ! myosin II filament organization + +[Term] +id: GO:1904901 +name: positive regulation of myosin II filament organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myosin II filament organization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] +synonym: "activation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "activation of myosin II filament organisation" NARROW [GOC:TermGenie] +synonym: "activation of myosin II filament organization" NARROW [GOC:TermGenie] +synonym: "activation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "positive regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "up regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "up regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "up regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "up-regulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +synonym: "upregulation of myosin II filament assembly or disassembly" RELATED [GOC:TermGenie] +synonym: "upregulation of myosin II filament organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of myosin II filament organization" EXACT [GOC:TermGenie] +synonym: "upregulation of myosin II polymerization or depolymerization" RELATED [GOC:TermGenie] +is_a: GO:0043519 ! regulation of myosin II filament organization +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +relationship: positively_regulates GO:0031038 ! myosin II filament organization + +[Term] +id: GO:1904902 +name: ESCRT III complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an ESCRT III complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296] +synonym: "ESCRT III complex formation" EXACT [GOC:TermGenie] +is_a: GO:1904895 ! ESCRT complex assembly + +[Term] +id: GO:1904903 +name: ESCRT III complex disassembly +namespace: biological_process +def: "The disaggregation of an ESCRT III complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:20588296] +is_a: GO:1904896 ! ESCRT complex disassembly + +[Term] +id: GO:1904904 +name: regulation of endothelial cell-matrix adhesion via fibronectin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +relationship: regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin + +[Term] +id: GO:1904905 +name: negative regulation of endothelial cell-matrix adhesion via fibronectin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] +synonym: "down regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +synonym: "inhibition of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie] +is_a: GO:0001953 ! negative regulation of cell-matrix adhesion +is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin +relationship: negatively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin + +[Term] +id: GO:1904906 +name: positive regulation of endothelial cell-matrix adhesion via fibronectin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell-matrix adhesion via fibronectin." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:19460962] +synonym: "activation of endothelial cell-matrix adhesion via fibronectin" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelial cell-matrix adhesion via fibronectin" EXACT [GOC:TermGenie] +is_a: GO:0001954 ! positive regulation of cell-matrix adhesion +is_a: GO:1904904 ! regulation of endothelial cell-matrix adhesion via fibronectin +relationship: positively_regulates GO:0090674 ! endothelial cell-matrix adhesion via fibronectin + +[Term] +id: GO:1904907 +name: regulation of maintenance of mitotic sister chromatid cohesion, telomeric +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] +synonym: "regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric + +[Term] +id: GO:1904908 +name: negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] +synonym: "down regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "down regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "down regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "down regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "downregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "inhibition of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie] +synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "negative regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric +relationship: negatively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric + +[Term] +id: GO:1904909 +name: positive regulation of maintenance of mitotic sister chromatid cohesion, telomeric +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281] +synonym: "activation of maintenance of mitotic sister chromatid cohesion, telomeric" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of mitotic sister chromatin cohesion at telomere" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of sister chromatin cohesion at telomere at mitosis" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of telomeric mitotic sister chromatin cohesion" NARROW [GOC:TermGenie] +synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "positive regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "up regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of mitotic sister chromatid cohesion, telomeric" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of mitotic sister chromatin cohesion at telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of sister chromatin cohesion at telomere at mitosis" EXACT [GOC:TermGenie] +synonym: "upregulation of maintenance of telomeric mitotic sister chromatin cohesion" EXACT [GOC:TermGenie] +is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:1904907 ! regulation of maintenance of mitotic sister chromatid cohesion, telomeric +relationship: positively_regulates GO:0099403 ! maintenance of mitotic sister chromatid cohesion, telomeric + +[Term] +id: GO:1904910 +name: regulation of establishment of RNA localization to telomere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0097694 ! establishment of RNA localization to telomere + +[Term] +id: GO:1904911 +name: negative regulation of establishment of RNA localization to telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "down regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of RNA localization to telomere" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere +relationship: negatively_regulates GO:0097694 ! establishment of RNA localization to telomere + +[Term] +id: GO:1904912 +name: positive regulation of establishment of RNA localization to telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of RNA localization to telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "activation of establishment of RNA localisation to telomere" NARROW [GOC:TermGenie] +synonym: "activation of establishment of RNA localization to telomere" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of RNA localisation to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of RNA localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1904910 ! regulation of establishment of RNA localization to telomere +relationship: positively_regulates GO:0097694 ! establishment of RNA localization to telomere + +[Term] +id: GO:1904913 +name: regulation of establishment of protein-containing complex localization to telomere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "regulation of establishment of macromolecular complex localization to telomere" RELATED [] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0097695 ! establishment of protein-containing complex localization to telomere + +[Term] +id: GO:1904914 +name: negative regulation of establishment of protein-containing complex localization to telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "down regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment of macromolecular complex localization to telomere" RELATED [] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere +relationship: negatively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere + +[Term] +id: GO:1904915 +name: positive regulation of establishment of protein-containing complex localization to telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of the localization of a protein-containing macromolecular complex to a telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26586433] +synonym: "activation of establishment of macromolecular complex localisation to telomere" NARROW [GOC:TermGenie] +synonym: "activation of establishment of macromolecular complex localization to telomere" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment of macromolecular complex localization to telomere" RELATED [] +synonym: "up regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of macromolecular complex localisation to telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of macromolecular complex localization to telomere" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1904913 ! regulation of establishment of protein-containing complex localization to telomere +relationship: positively_regulates GO:0097695 ! establishment of protein-containing complex localization to telomere + +[Term] +id: GO:1904916 +name: transmembrane L-lysine transport from lysosomal lumen to cytosol +namespace: biological_process +def: "The directed movement of L-lysine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:1903401 ! L-lysine transmembrane transport + +[Term] +id: GO:1904917 +name: L-arginine transmembrane transport from lysosomal lumen to cytosol +namespace: biological_process +def: "The directed movement of L-arginine across a membrane from lysosomal lumen to cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] +synonym: "transmembrane L-arginine transport from lysosomal lumen to cytosol" EXACT [] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1904918 +name: transmembrane L-histidine transport from lysosomal lumen to cytosol +namespace: biological_process +def: "The directed movement of L-histidine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0089709 ! L-histidine transmembrane transport + +[Term] +id: GO:1904919 +name: transmembrane L-cystine transport from lysosomal lumen to cytosol +namespace: biological_process +def: "The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol." [GO_REF:0000078, GOC:kmv, GOC:TermGenie, PMID:22822152] +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0015811 ! L-cystine transport +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1904920 +name: obsolete regulation of MAPK cascade involved in axon regeneration +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904921 +name: obsolete negative regulation of MAPK cascade involved in axon regeneration +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "down regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "down regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "down regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "down regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "down regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "down-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "down-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "down-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "down-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "downregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "downregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "downregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "downregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "inhibition of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "inhibition of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "inhibition of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "negative regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "negative regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "negative regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "negative regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "negative regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "negative regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "negative regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "negative regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904922 +name: obsolete positive regulation of MAPK cascade involved in axon regeneration +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:20203177] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "activation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAP kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAP kinase kinase kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAPK signal transduction involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "activation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "activation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of MAPKKK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "activation of mitogen-activated protein kinase cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "positive regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "positive regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "positive regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "positive regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "positive regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "positive regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "positive regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "positive regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "up regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "up regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "up regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "up regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "up-regulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "up-regulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "up-regulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "up-regulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of ERK/MAPK cascade involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "upregulation of MAP kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of MAP kinase kinase kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of MAPK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of MAPK signal transduction involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of MAPK signaling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "upregulation of MAPK signalling involved in axon regeneration" RELATED [GOC:TermGenie] +synonym: "upregulation of MAPKKK cascade during sporulation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "upregulation of MAPKKK cascade involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of mitogen-activated protein kinase cascade involved in axon regeneration" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904923 +name: regulation of autophagy of mitochondrion in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of autophagy of mitochondrion in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +is_a: GO:0098780 ! response to mitochondrial depolarisation +relationship: regulates GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:1904924 +name: negative regulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +synonym: "down regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] +is_a: GO:1904923 ! regulation of autophagy of mitochondrion in response to mitochondrial depolarization +relationship: negatively_regulates GO:0000423 ! mitophagy + +[Term] +id: GO:1904925 +name: positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of autophagy of the mitochondrion in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22020285] +synonym: "activation of mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] +synonym: "up regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +is_a: GO:1904923 ! regulation of autophagy of mitochondrion in response to mitochondrial depolarization +relationship: positively_regulates GO:0000422 ! autophagy of mitochondrion + +[Term] +id: GO:1904926 +name: response to palmitoleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1904927 +name: cellular response to palmitoleic acid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a palmitoleic acid stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:25429233] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:1904926 ! response to palmitoleic acid + +[Term] +id: GO:1904928 +name: coreceptor activity involved in canonical Wnt signaling pathway +namespace: molecular_function +def: "Any coreceptor activity that is involved in a canonical Wnt signaling pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] +synonym: "coreceptor activity involved in canonical Wnt receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in canonical Wnt-activated signaling pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in frizzled-1 receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in canonical Wnt receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in canonical Wnt signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in canonical Wnt-activated signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in frizzled-1 receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway through beta-catenin" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway via beta-catenin" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway through beta-catenin" RELATED [GOC:TermGenie] +synonym: "Wnt co-receptor activity, canonical signaling" EXACT [GOC:bf] +synonym: "Wnt co-receptor, canonical pathway" EXACT [GOC:bf] +is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway + +[Term] +id: GO:1904929 +name: coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway +namespace: molecular_function +def: "Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway." [GO_REF:0000061, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] +synonym: "coreceptor activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor activity involved in PCP pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in planar cell polarity pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, insoluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in non-canonical Wnt signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in PCP pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt receptor signalling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt-activated signaling pathway, planar cell polarity pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt-JNK signaling pathway" RELATED [GOC:TermGenie] +synonym: "coreceptor, soluble ligand activity involved in Wnt-PCP signaling pathway" RELATED [GOC:TermGenie] +synonym: "Wnt co-receptor activity, non-canonical signaling" BROAD [GOC:bf] +synonym: "Wnt co-receptor, non-canonical pathway" BROAD [GOC:bf] +synonym: "Wnt/PCP co-receptor activity" EXACT [PMID:24431302] +is_a: GO:0071936 ! coreceptor activity involved in Wnt signaling pathway + +[Term] +id: GO:1904930 +name: amphisome membrane +namespace: cellular_component +def: "Any membrane that is part of an amphisome." [GO_REF:0000064, GOC:bhm, GOC:TermGenie, PMID:17984323] +is_a: GO:0000421 ! autophagosome membrane +relationship: part_of GO:0044753 ! amphisome + +[Term] +id: GO:1904931 +name: MCM complex binding +namespace: molecular_function +def: "Binding to an MCM complex." [GOC:TermGenie, PMID:12604790] +synonym: "mini-chromosome maintenance complex binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1904932 +name: negative regulation of cartilage condensation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cartilage condensation." [GO_REF:0000058, GOC:mr, GOC:TermGenie, PMID:17604018] +synonym: "down regulation of cartilage condensation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cartilage condensation" EXACT [GOC:TermGenie] +synonym: "downregulation of cartilage condensation" EXACT [GOC:TermGenie] +synonym: "inhibition of cartilage condensation" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1902026 ! regulation of cartilage condensation +relationship: negatively_regulates GO:0001502 ! cartilage condensation + +[Term] +id: GO:1904933 +name: regulation of cell proliferation in midbrain +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] +synonym: "regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: regulates GO:0033278 ! cell proliferation in midbrain + +[Term] +id: GO:1904934 +name: negative regulation of cell proliferation in midbrain +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18953410, PMID:24431302] +synonym: "down regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "down regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "down regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "down-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "downregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "downregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "downregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "inhibition of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] +synonym: "inhibition of cell proliferation in midbrain" NARROW [GOC:TermGenie] +synonym: "inhibition of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "negative regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "negative regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +is_a: GO:1904933 ! regulation of cell proliferation in midbrain +is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0033278 ! cell proliferation in midbrain + +[Term] +id: GO:1904935 +name: positive regulation of cell proliferation in midbrain +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24431302] +synonym: "activation of cell proliferation in mesencephalon" NARROW [GOC:TermGenie] +synonym: "activation of cell proliferation in midbrain" NARROW [GOC:TermGenie] +synonym: "activation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "positive regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "up regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "up regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "up regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +synonym: "upregulation of cell proliferation in mesencephalon" EXACT [GOC:TermGenie] +synonym: "upregulation of cell proliferation in midbrain" EXACT [GOC:TermGenie] +synonym: "upregulation of mesencepahalic cell proliferation" RELATED [GOC:TermGenie] +is_a: GO:1904933 ! regulation of cell proliferation in midbrain +is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0033278 ! cell proliferation in midbrain + +[Term] +id: GO:1904936 +name: interneuron migration +namespace: biological_process +def: "The orderly movement of an interneuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] +synonym: "inter neuron migration" EXACT [GOC:ah] +synonym: "inter-neuron migration" EXACT [GOC:ah] +is_a: GO:0001764 ! neuron migration + +[Term] +id: GO:1904937 +name: sensory neuron migration +namespace: biological_process +def: "The orderly movement of a sensory neuron from one site to another." [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031] +is_a: GO:0001764 ! neuron migration + +[Term] +id: GO:1904938 +name: planar cell polarity pathway involved in axon guidance +namespace: biological_process +def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21106844, PMID:23517308] +synonym: "non-canonical Wnt signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] +synonym: "PCP pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "PCP pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "PCP pathway involved in axon guidance" EXACT [GOC:TermGenie] +synonym: "PCP pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:bf] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon growth cone guidance" NARROW [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon guidance" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in axon pathfinding" EXACT [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling involved in axon guidance" EXACT [GOC:bf] +synonym: "Wnt-PCP signaling pathway involved in axon chemotaxis" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in axon growth cone guidance" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in axon guidance" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in axon pathfinding" RELATED [GOC:TermGenie] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:1904939 +name: regulation of DNA nucleotidylexotransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +synonym: "regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of TdT" RELATED [GOC:TermGenie] +synonym: "regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of terminal transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1904940 +name: negative regulation of DNA nucleotidylexotransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +synonym: "down regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of TdT" RELATED [GOC:TermGenie] +synonym: "down regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "down regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of TdT" RELATED [GOC:TermGenie] +synonym: "down-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of addase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of TdT" RELATED [GOC:TermGenie] +synonym: "downregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "downregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of addase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of TdT" RELATED [GOC:TermGenie] +synonym: "inhibition of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "inhibition of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of terminal transferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of TdT" RELATED [GOC:TermGenie] +synonym: "negative regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of terminal transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity + +[Term] +id: GO:1904941 +name: positive regulation of DNA nucleotidylexotransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA nucleotidylexotransferase activity." [GO_REF:0000059, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +synonym: "activation of addase activity" NARROW [GOC:TermGenie] +synonym: "activation of deoxynucleotidyl terminal transferase activity" NARROW [GOC:TermGenie] +synonym: "activation of deoxyribonucleic acid nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of deoxyribonucleic nucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of DNA nucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of TdT" RELATED [GOC:TermGenie] +synonym: "activation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "activation of terminal deoxynucleotide transferase activity" NARROW [GOC:TermGenie] +synonym: "activation of terminal deoxynucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of terminal deoxyribonucleotidyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of terminal transferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of TdT" RELATED [GOC:TermGenie] +synonym: "positive regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of TdT" RELATED [GOC:TermGenie] +synonym: "up regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "up regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of addase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of TdT" RELATED [GOC:TermGenie] +synonym: "up-regulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of addase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxynucleotidyl terminal transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleic acid nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of deoxyribonucleic nucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA nucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of TdT" RELATED [GOC:TermGenie] +synonym: "upregulation of terminal addition enzyme activity" RELATED [GOC:TermGenie] +synonym: "upregulation of terminal deoxynucleotide transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal deoxynucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal deoxyribonucleotidyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of terminal transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1904939 ! regulation of DNA nucleotidylexotransferase activity + +[Term] +id: GO:1904942 +name: regulation of cardiac ventricle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +is_a: GO:1901210 ! regulation of cardiac chamber formation +relationship: regulates GO:0003211 ! cardiac ventricle formation + +[Term] +id: GO:1904943 +name: negative regulation of cardiac ventricle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +synonym: "down regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac ventricle formation" NARROW [GOC:TermGenie] +is_a: GO:1901211 ! negative regulation of cardiac chamber formation +is_a: GO:1904413 ! negative regulation of cardiac ventricle development +is_a: GO:1904942 ! regulation of cardiac ventricle formation +relationship: negatively_regulates GO:0003211 ! cardiac ventricle formation + +[Term] +id: GO:1904944 +name: positive regulation of cardiac ventricle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23575307] +synonym: "activation of cardiac ventricle formation" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac ventricle formation" EXACT [GOC:TermGenie] +is_a: GO:1901212 ! positive regulation of cardiac chamber formation +is_a: GO:1904942 ! regulation of cardiac ventricle formation +relationship: positively_regulates GO:0003211 ! cardiac ventricle formation + +[Term] +id: GO:1904945 +name: obsolete response to cobalt(II) acetate +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1904946 +name: obsolete cellular response to cobalt(II) acetate +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt(II) acetate stimulus." [GO_REF:0000071, GOC:mr, GOC:TermGenie, PMID:24315322] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1904947 +name: folate import into mitochondrion +namespace: biological_process +def: "The process in which folic acid is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000075, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:15140890] +synonym: "folic acid import into mitochondrion" RELATED [] +is_a: GO:0098838 ! folate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1904948 +name: midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron." [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665] +synonym: "DA neurogenesis from midbrain floor plate" EXACT [PMID:19122665] +synonym: "mDA neuron differentiation" EXACT [PMID:24287202] +synonym: "midbrain DA neurogenesis" EXACT [PMID:19122665] +synonym: "midbrain dopaminergic neuron production" EXACT [PMID:19122665] +is_a: GO:0071542 ! dopaminergic neuron differentiation +relationship: part_of GO:0030901 ! midbrain development + +[Term] +id: GO:1904949 +name: ATPase complex +namespace: cellular_component +def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] +comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). +synonym: "VPS4 complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1904950 +name: negative regulation of establishment of protein localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] +synonym: "down regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "down regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "down regulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "downregulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "downregulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "inhibition of establishment of protein localisation" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment of protein localization" NARROW [GOC:TermGenie] +synonym: "inhibition of protein positioning" NARROW [GOC:TermGenie] +synonym: "inhibition of protein recruitment" NARROW [GOC:TermGenie] +synonym: "negative regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein recruitment" EXACT [GOC:TermGenie] +is_a: GO:0070201 ! regulation of establishment of protein localization +is_a: GO:1903828 ! negative regulation of protein localization +relationship: negatively_regulates GO:0045184 ! establishment of protein localization + +[Term] +id: GO:1904951 +name: positive regulation of establishment of protein localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of protein localization." [GO_REF:0000058, GOC:TermGenie, PMID:22761445] +synonym: "activation of establishment of protein localisation" NARROW [GOC:TermGenie] +synonym: "activation of establishment of protein localization" NARROW [GOC:TermGenie] +synonym: "activation of protein positioning" NARROW [GOC:TermGenie] +synonym: "activation of protein recruitment" NARROW [GOC:TermGenie] +synonym: "positive regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "up regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "up regulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein recruitment" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localisation" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment of protein localization" EXACT [GOC:TermGenie] +synonym: "upregulation of protein positioning" EXACT [GOC:TermGenie] +synonym: "upregulation of protein recruitment" EXACT [GOC:TermGenie] +is_a: GO:0070201 ! regulation of establishment of protein localization +is_a: GO:1903829 ! positive regulation of protein localization +relationship: positively_regulates GO:0045184 ! establishment of protein localization + +[Term] +id: GO:1904952 +name: hydroxycinnamic acid transport +namespace: biological_process +def: "The directed movement of a hydroxycinnamic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26744218] +is_a: GO:0015849 ! organic acid transport + +[Term] +id: GO:1904953 +name: Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250, PMID:22988876, PMID:23517308] +synonym: "frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "Wnt-mediated midbrain DA neuron differentiation" EXACT [PMID:23517308] +is_a: GO:0016055 ! Wnt signaling pathway +relationship: part_of GO:1904948 ! midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904954 +name: canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876] +synonym: "canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:bf] +synonym: "frizzled-1 receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +is_a: GO:0060070 ! canonical Wnt signaling pathway +is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904955 +name: planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22988876] +synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" BROAD [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" BROAD [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" BROAD [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" BROAD [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" BROAD [GOC:TermGenie] +synonym: "non-canonical Wnt-mediated midbrain DA neuron differentiation" BROAD [GOC:bf] +synonym: "PCP pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "PCP pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "PCP pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "PCP pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "PCP pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [] +synonym: "Wnt signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-JNK signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "Wnt-PCP signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway +is_a: GO:1905438 ! non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904956 +name: regulation of midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] +synonym: "regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +is_a: GO:1904338 ! regulation of dopaminergic neuron differentiation +relationship: regulates GO:1904948 ! midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904957 +name: negative regulation of midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "inhibition of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "negative regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +is_a: GO:1904339 ! negative regulation of dopaminergic neuron differentiation +is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation +relationship: negatively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904958 +name: positive regulation of midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:21347250] +synonym: "activation of DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "positive regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +is_a: GO:1904340 ! positive regulation of dopaminergic neuron differentiation +is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation +relationship: positively_regulates GO:1904948 ! midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1904959 +name: regulation of cytochrome-c oxidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017] +synonym: "regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1904732 ! regulation of electron transfer activity + +[Term] +id: GO:1904960 +name: positive regulation of cytochrome-c oxidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26734017] +synonym: "activation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "activation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "activation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "activation of cytochrome c oxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "activation of cytochrome-c oxidase activity" NARROW [GOC:TermGenie] +synonym: "activation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "activation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "activation of indophenolase" NARROW [GOC:TermGenie] +synonym: "activation of NADH cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "activation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "positive regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "positive regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "positive regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "positive regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "up regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "up regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "up regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "up regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "up regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "up regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "up regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "up-regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "up-regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "up-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "up-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "upregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "upregulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "upregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "upregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "upregulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "upregulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "upregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "upregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1904734 ! positive regulation of electron transfer activity +is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity + +[Term] +id: GO:1904961 +name: quiescent center organization +namespace: biological_process +def: "The process that contributes to the act of creating the structural organization of the quiescent center. This process pertains to the physical shaping of a rudimentary structure." [GO_REF:0000084, GOC:TermGenie, PMID:21233333] +synonym: "quiescent center structural organization" EXACT [] +is_a: GO:0048532 ! anatomical structure arrangement + +[Term] +id: GO:1904962 +name: plastid to vacuole vesicle-mediated transport +namespace: biological_process +def: "The vesicle-mediated and directed movement of substances from plastid to vacuole." [GO_REF:0000076, GOC:TermGenie, PMID:25281689] +synonym: "plastid to vacuolar carboxypeptidase Y vesicle-mediated transport" RELATED [GOC:TermGenie] +is_a: GO:0007034 ! vacuolar transport +is_a: GO:0016192 ! vesicle-mediated transport +is_a: GO:0016482 ! cytosolic transport + +[Term] +id: GO:1904963 +name: regulation of phytol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650] +synonym: "regulation of phytol anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of phytol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of phytol formation" EXACT [GOC:TermGenie] +synonym: "regulation of phytol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0046890 ! regulation of lipid biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0033520 ! phytol biosynthetic process + +[Term] +id: GO:1904964 +name: positive regulation of phytol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phytol biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:24275650] +synonym: "activation of phytol anabolism" NARROW [GOC:TermGenie] +synonym: "activation of phytol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of phytol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of phytol formation" NARROW [GOC:TermGenie] +synonym: "activation of phytol synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of phytol anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of phytol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of phytol formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of phytol synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phytol anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of phytol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phytol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of phytol formation" EXACT [GOC:TermGenie] +synonym: "up regulation of phytol synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phytol anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of phytol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phytol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of phytol formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of phytol synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phytol anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of phytol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phytol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of phytol formation" EXACT [GOC:TermGenie] +synonym: "upregulation of phytol synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process +is_a: GO:0046889 ! positive regulation of lipid biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +is_a: GO:1904963 ! regulation of phytol biosynthetic process +relationship: positively_regulates GO:0033520 ! phytol biosynthetic process + +[Term] +id: GO:1904965 +name: regulation of vitamin E biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244] +synonym: "regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of vitamin E anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of vitamin E formation" EXACT [GOC:TermGenie] +synonym: "regulation of vitamin E synthesis" EXACT [GOC:TermGenie] +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0010189 ! vitamin E biosynthetic process + +[Term] +id: GO:1904966 +name: positive regulation of vitamin E biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vitamin E biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:20823244] +synonym: "activation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of vitamin E anabolism" NARROW [GOC:TermGenie] +synonym: "activation of vitamin E biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of vitamin E biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of vitamin E formation" NARROW [GOC:TermGenie] +synonym: "activation of vitamin E synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin E anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin E formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of vitamin E synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin E anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin E formation" EXACT [GOC:TermGenie] +synonym: "up regulation of vitamin E synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "up-regulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "up-regulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin E anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin E formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vitamin E synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-tocopherol biosynthesis" NARROW [GOC:TermGenie] +synonym: "upregulation of alpha-tocopherol biosynthetic process" NARROW [GOC:TermGenie] +synonym: "upregulation of tocopherol biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of tocopherol biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin E anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin E biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin E biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin E formation" EXACT [GOC:TermGenie] +synonym: "upregulation of vitamin E synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0046136 ! positive regulation of vitamin metabolic process +is_a: GO:1904965 ! regulation of vitamin E biosynthetic process +relationship: positively_regulates GO:0010189 ! vitamin E biosynthetic process + +[Term] +id: GO:1904967 +name: regulation of monopolar spindle attachment to meiosis I kinetochore +namespace: biological_process +alt_id: GO:0090699 +def: "Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:21920317, PMID:23770679] +synonym: "correction of merotelic kinetochore attachment, meiosis I" RELATED [] +synonym: "regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] +synonym: "regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "regulation of monopolar attachment" EXACT [GOC:TermGenie] +synonym: "regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +synonym: "repair of merotelic kinetochore attachment defect, meiosis I" RELATED [] +is_a: GO:0051988 ! regulation of attachment of spindle microtubules to kinetochore +is_a: GO:0140274 ! repair of kinetochore microtubule attachment defect +is_a: GO:1903046 ! meiotic cell cycle process +is_a: GO:2000241 ! regulation of reproductive process +relationship: part_of GO:0043060 ! meiotic metaphase I plate congression +relationship: regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore + +[Term] +id: GO:1904968 +name: positive regulation of monopolar spindle attachment to meiosis I kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation." [GO_REF:0000058, GOC:TermGenie, PMID:23770679] +synonym: "activation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "activation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" NARROW [GOC:TermGenie] +synonym: "activation of attachment of spindle microtubules to kinetochore involved in meiosis I" NARROW [GOC:TermGenie] +synonym: "activation of monopolar attachment" NARROW [GOC:TermGenie] +synonym: "activation of sister kinetochore mono-orientation" NARROW [GOC:TermGenie] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [] +synonym: "positive regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "positive regulation of monopolar attachment" EXACT [GOC:TermGenie] +synonym: "positive regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "up regulation of monopolar attachment" EXACT [GOC:TermGenie] +synonym: "up regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] +synonym: "up-regulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "up-regulation of monopolar attachment" EXACT [GOC:TermGenie] +synonym: "up-regulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation" EXACT [GOC:TermGenie] +synonym: "upregulation of attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "upregulation of monopolar attachment" EXACT [GOC:TermGenie] +synonym: "upregulation of sister kinetochore mono-orientation" EXACT [GOC:TermGenie] +is_a: GO:0051987 ! positive regulation of attachment of spindle microtubules to kinetochore +is_a: GO:1904967 ! regulation of monopolar spindle attachment to meiosis I kinetochore +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore + +[Term] +id: GO:1904969 +name: slow muscle cell migration +namespace: biological_process +def: "The orderly movement of a slow muscle cell from one site to another." [GO_REF:0000091, GOC:TermGenie, GOC:ymb, PMID:14667409, PMID:15572133, PMID:25534553] +comment: The directional migration of a slow muscle cell from one site to another within the embryo. +synonym: "slow-twitch muscle cell migration" EXACT [PMID:14667409] +is_a: GO:0110122 ! myotube cell migration + +[Term] +id: GO:1904970 +name: brush border assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border." [GO_REF:0000079, GOC:lb, GOC:TermGenie, PMID:24725409] +synonym: "brush border formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly + +[Term] +id: GO:1904971 +name: regulation of viral translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] +synonym: "regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "regulation of viral protein synthesis" EXACT [GOC:TermGenie] +is_a: GO:0050792 ! regulation of viral process +relationship: regulates GO:0019081 ! viral translation + +[Term] +id: GO:1904972 +name: negative regulation of viral translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] +synonym: "down regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "down regulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of viral translation" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of viral translation" EXACT [GOC:TermGenie] +synonym: "downregulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "downregulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of viral translation" EXACT [GOC:TermGenie] +synonym: "inhibition of viral protein anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of viral protein biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of viral protein biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of viral protein formation" NARROW [GOC:TermGenie] +synonym: "inhibition of viral protein synthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of viral translation" NARROW [GOC:TermGenie] +synonym: "negative regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of viral protein synthesis" EXACT [GOC:TermGenie] +is_a: GO:0048525 ! negative regulation of viral process +is_a: GO:1904971 ! regulation of viral translation +relationship: negatively_regulates GO:0019081 ! viral translation + +[Term] +id: GO:1904973 +name: positive regulation of viral translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral translation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:19666601] +synonym: "activation of viral protein anabolism" NARROW [GOC:TermGenie] +synonym: "activation of viral protein biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of viral protein biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of viral protein formation" NARROW [GOC:TermGenie] +synonym: "activation of viral protein synthesis" NARROW [GOC:TermGenie] +synonym: "activation of viral translation" NARROW [GOC:TermGenie] +synonym: "positive regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "up regulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of viral translation" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral translation" EXACT [GOC:TermGenie] +synonym: "upregulation of viral protein anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of viral protein biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of viral protein biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of viral protein formation" EXACT [GOC:TermGenie] +synonym: "upregulation of viral protein synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of viral translation" EXACT [GOC:TermGenie] +is_a: GO:0048524 ! positive regulation of viral process +is_a: GO:1904971 ! regulation of viral translation +relationship: positively_regulates GO:0019081 ! viral translation + +[Term] +id: GO:1904974 +name: heparanase complex +namespace: cellular_component +def: "A protein complex which is capable of heparanase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:12927802] +comment: An example of this is HPSE in human (Q9Y251) in PMID:12927802 (inferred from direct assay). +synonym: "HEPS complex" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1904975 +name: response to bleomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:1904976 +name: cellular response to bleomycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bleomycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11553781] +is_a: GO:1901653 ! cellular response to peptide +is_a: GO:1904975 ! response to bleomycin + +[Term] +id: GO:1904977 +name: lymphatic endothelial cell migration +namespace: biological_process +def: "The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel." [GO_REF:0000091, GOC:TermGenie, PMID:25745057] +is_a: GO:0043542 ! endothelial cell migration +relationship: part_of GO:0036303 ! lymph vessel morphogenesis + +[Term] +id: GO:1904978 +name: regulation of endosome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] +synonym: "regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0007032 ! endosome organization + +[Term] +id: GO:1904979 +name: negative regulation of endosome organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] +synonym: "down regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "down regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "downregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of endosome organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of endosome organization" NARROW [GOC:TermGenie] +synonym: "inhibition of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1904978 ! regulation of endosome organization +relationship: negatively_regulates GO:0007032 ! endosome organization + +[Term] +id: GO:1904980 +name: positive regulation of endosome organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endosome organization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:22511594] +synonym: "activation of endosome organisation" NARROW [GOC:TermGenie] +synonym: "activation of endosome organization" NARROW [GOC:TermGenie] +synonym: "activation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "up regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of endosome organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of endosome organization" EXACT [GOC:TermGenie] +synonym: "upregulation of endosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1904978 ! regulation of endosome organization +relationship: positively_regulates GO:0007032 ! endosome organization + +[Term] +id: GO:1904981 +name: maltose transmembrane transport +namespace: biological_process +def: "The process in which maltose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464] +is_a: GO:0015768 ! maltose transport +is_a: GO:0034219 ! carbohydrate transmembrane transport + +[Term] +id: GO:1904982 +name: sucrose transmembrane transport +namespace: biological_process +def: "The process in which sucrose is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:11136464] +is_a: GO:0015770 ! sucrose transport +is_a: GO:0034219 ! carbohydrate transmembrane transport + +[Term] +id: GO:1904983 +name: glycine import into mitochondrion +namespace: biological_process +def: "The process in which glycine is transported from the cytosol into the mitochondrial matrix." [GO_REF:0000078, GOC:TermGenie, PMID:26821380] +synonym: "transmembrane glycine transport from cytosol to mitochondrion" EXACT [] +is_a: GO:0015816 ! glycine transport +is_a: GO:0043090 ! amino acid import +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1904984 +name: regulation of quinolinate biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] +synonym: "regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +is_a: GO:0062012 ! regulation of small molecule metabolic process +relationship: regulates GO:0019805 ! quinolinate biosynthetic process + +[Term] +id: GO:1904985 +name: negative regulation of quinolinate biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] +synonym: "down regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "down regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "downregulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of quinolinate anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of quinolinate biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of quinolinate biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of quinolinate formation" NARROW [GOC:TermGenie] +synonym: "inhibition of quinolinate synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:1904984 ! regulation of quinolinate biosynthetic process +relationship: negatively_regulates GO:0019805 ! quinolinate biosynthetic process + +[Term] +id: GO:1904986 +name: positive regulation of quinolinate biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of quinolinate biosynthetic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of quinolinate anabolism" NARROW [GOC:TermGenie] +synonym: "activation of quinolinate biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of quinolinate biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of quinolinate formation" NARROW [GOC:TermGenie] +synonym: "activation of quinolinate synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "up regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of quinolinate synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of quinolinate anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of quinolinate biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of quinolinate biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of quinolinate formation" EXACT [GOC:TermGenie] +synonym: "upregulation of quinolinate synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:1904984 ! regulation of quinolinate biosynthetic process +relationship: positively_regulates GO:0019805 ! quinolinate biosynthetic process + +[Term] +id: GO:1904987 +name: regulation of endothelial cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0042118 ! endothelial cell activation + +[Term] +id: GO:1904988 +name: negative regulation of endothelial cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] +synonym: "down regulation of endothelial cell activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelial cell activation" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelial cell activation" EXACT [GOC:TermGenie] +synonym: "inhibition of endothelial cell activation" NARROW [GOC:TermGenie] +is_a: GO:0050866 ! negative regulation of cell activation +is_a: GO:1904987 ! regulation of endothelial cell activation +relationship: negatively_regulates GO:0042118 ! endothelial cell activation + +[Term] +id: GO:1904989 +name: positive regulation of endothelial cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell activation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24255059] +synonym: "activation of endothelial cell activation" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelial cell activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelial cell activation" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelial cell activation" EXACT [GOC:TermGenie] +is_a: GO:0050867 ! positive regulation of cell activation +is_a: GO:1904987 ! regulation of endothelial cell activation +relationship: positively_regulates GO:0042118 ! endothelial cell activation + +[Term] +id: GO:1904990 +name: regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] +synonym: "regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +is_a: GO:0060159 ! regulation of dopamine receptor signaling pathway +relationship: regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway + +[Term] +id: GO:1904991 +name: negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] +synonym: "down regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "down-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "downregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "inhibition of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "negative regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:0060160 ! negative regulation of dopamine receptor signaling pathway +is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway +relationship: negatively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway + +[Term] +id: GO:1904992 +name: positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819] +synonym: "activation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of dopamine receptor, adenylate cyclase inhibiting pathway" NARROW [GOC:TermGenie] +synonym: "activation of dopamine receptor, adenylyl cyclase inhibiting pathway" NARROW [GOC:TermGenie] +synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "activation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "positive regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "up-regulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:TermGenie] +synonym: "upregulation of inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:0060161 ! positive regulation of dopamine receptor signaling pathway +is_a: GO:1904990 ! regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway +relationship: positively_regulates GO:0007195 ! adenylate cyclase-inhibiting dopamine receptor signaling pathway + +[Term] +id: GO:1904993 +name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any positive regulation of cyclin-dependent protein serine/threonine kinase activity that is involved in positive regulation of G2/M transition of mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie, PMID:24728197] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "activation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie] +synonym: "positive regulation of CDK activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "positive regulation of CDK activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] +synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] +synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" NARROW [GOC:TermGenie] +synonym: "stimulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" NARROW [GOC:TermGenie] +synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "up-regulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle" EXACT [GOC:TermGenie] +synonym: "upregulation of cyclin-dependent protein kinase activity involved in positive regulation of mitotic entry" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1904994 +name: regulation of leukocyte adhesion to vascular endothelial cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell + +[Term] +id: GO:1904995 +name: negative regulation of leukocyte adhesion to vascular endothelial cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] +synonym: "down regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +synonym: "inhibition of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie] +is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion +is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell +relationship: negatively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell + +[Term] +id: GO:1904996 +name: positive regulation of leukocyte adhesion to vascular endothelial cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to vascular endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23897866] +synonym: "activation of leukocyte adhesion to vascular endothelial cell" NARROW [GOC:TermGenie] +synonym: "up regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte adhesion to vascular endothelial cell" EXACT [GOC:TermGenie] +is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion +is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell +relationship: positively_regulates GO:0061756 ! leukocyte adhesion to vascular endothelial cell + +[Term] +id: GO:1904997 +name: regulation of leukocyte adhesion to arterial endothelial cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] +is_a: GO:1904994 ! regulation of leukocyte adhesion to vascular endothelial cell +relationship: regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell + +[Term] +id: GO:1904998 +name: negative regulation of leukocyte adhesion to arterial endothelial cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] +synonym: "down regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +synonym: "downregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +synonym: "inhibition of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie] +is_a: GO:1904995 ! negative regulation of leukocyte adhesion to vascular endothelial cell +is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell +relationship: negatively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell + +[Term] +id: GO:1904999 +name: positive regulation of leukocyte adhesion to arterial endothelial cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] +synonym: "activation of leukocyte adhesion to arterial endothelial cell" NARROW [GOC:TermGenie] +synonym: "up regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +synonym: "upregulation of leukocyte adhesion to arterial endothelial cell" EXACT [GOC:TermGenie] +is_a: GO:1904996 ! positive regulation of leukocyte adhesion to vascular endothelial cell +is_a: GO:1904997 ! regulation of leukocyte adhesion to arterial endothelial cell +relationship: positively_regulates GO:0061757 ! leukocyte adhesion to arterial endothelial cell + +[Term] +id: GO:1905000 +name: regulation of membrane repolarization during atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] +synonym: "regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +is_a: GO:0060372 ! regulation of atrial cardiac muscle cell membrane repolarization +is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential +relationship: regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential + +[Term] +id: GO:1905001 +name: negative regulation of membrane repolarization during atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] +synonym: "down regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "down regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "down regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "down-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "down-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "downregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "downregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "inhibition of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "inhibition of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "negative regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential +is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential +relationship: negatively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential + +[Term] +id: GO:1905002 +name: positive regulation of membrane repolarization during atrial cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:21098446] +synonym: "activation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "activation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "activation of membrane repolarization during atrial cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "positive regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "up regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "up regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "up regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "up-regulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "up-regulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of atrial repolarization" RELATED [GOC:TermGenie] +synonym: "upregulation of electrocardiogram QRS complex" RELATED [GOC:TermGenie] +synonym: "upregulation of membrane repolarization during atrial cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1905000 ! regulation of membrane repolarization during atrial cardiac muscle cell action potential +is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential +relationship: positively_regulates GO:0098914 ! membrane repolarization during atrial cardiac muscle cell action potential + +[Term] +id: GO:1905003 +name: picolinic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166] +synonym: "picolinate metabolism" EXACT [CHEBI:38184] +synonym: "picolinic acid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006725 ! cellular aromatic compound metabolic process +is_a: GO:0032787 ! monocarboxylic acid metabolic process +is_a: GO:0072524 ! pyridine-containing compound metabolic process + +[Term] +id: GO:1905004 +name: picolinic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of picolinic acid." [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166] +synonym: "picolinate biosynthesis" EXACT [CHEBI:38184] +synonym: "picolinate biosynthetic process" EXACT [CHEBI:38184] +synonym: "picolinic acid anabolism" EXACT [GOC:TermGenie] +synonym: "picolinic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "picolinic acid formation" EXACT [GOC:TermGenie] +synonym: "picolinic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0019438 ! aromatic compound biosynthetic process +is_a: GO:0072330 ! monocarboxylic acid biosynthetic process +is_a: GO:0072525 ! pyridine-containing compound biosynthetic process +is_a: GO:1905003 ! picolinic acid metabolic process + +[Term] +id: GO:1905005 +name: regulation of epithelial to mesenchymal transition involved in endocardial cushion formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +is_a: GO:0062042 ! regulation of cardiac epithelial to mesenchymal transition +relationship: regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation + +[Term] +id: GO:1905006 +name: negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "down regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie] +is_a: GO:0062044 ! negative regulation of cardiac epithelial to mesenchymal transition +is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation +relationship: negatively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation + +[Term] +id: GO:1905007 +name: positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial to mesenchymal transition involved in endocardial cushion formation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "activation of epithelial to mesenchymal transition involved in endocardial cushion formation" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial to mesenchymal transition involved in endocardial cushion formation" EXACT [GOC:TermGenie] +is_a: GO:0062043 ! positive regulation of cardiac epithelial to mesenchymal transition +is_a: GO:1905005 ! regulation of epithelial to mesenchymal transition involved in endocardial cushion formation +relationship: positively_regulates GO:0003198 ! epithelial to mesenchymal transition involved in endocardial cushion formation + +[Term] +id: GO:1905008 +name: regulation of L-lysine import across plasma membrane +namespace: biological_process +alt_id: GO:0010805 +def: "Any process that modulates the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] +synonym: "regulation of L-lysine import into cell" EXACT [] +synonym: "regulation of lysine import" BROAD [] +synonym: "regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0097639 ! L-lysine import across plasma membrane + +[Term] +id: GO:1905009 +name: negative regulation of L-lysine import across plasma membrane +namespace: biological_process +alt_id: GO:0010806 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] +synonym: "down regulation of L-lysine import into cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-lysine import into cell" EXACT [GOC:TermGenie] +synonym: "downregulation of L-lysine import into cell" EXACT [GOC:TermGenie] +synonym: "inhibition of L-lysine import into cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-lysine import into cell" EXACT [] +synonym: "negative regulation of lysine import" BROAD [] +synonym: "negative regulation of lysine uptake" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane +relationship: negatively_regulates GO:0097639 ! L-lysine import across plasma membrane + +[Term] +id: GO:1905010 +name: positive regulation of L-lysine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-lysine import into cell." [GO_REF:0000058, GOC:TermGenie, PMID:7499219] +synonym: "activation of L-lysine import into cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-lysine import into cell" EXACT [] +synonym: "up regulation of L-lysine import into cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-lysine import into cell" EXACT [GOC:TermGenie] +synonym: "upregulation of L-lysine import into cell" EXACT [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:1905008 ! regulation of L-lysine import across plasma membrane +relationship: positively_regulates GO:0097639 ! L-lysine import across plasma membrane + +[Term] +id: GO:1905011 +name: transmembrane phosphate ion transport from cytosol to vacuole +namespace: biological_process +alt_id: GO:0007037 +def: "The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen." [GO_REF:0000078, GOC:TermGenie, PMID:26554016] +synonym: "vacuolar phosphate transport" BROAD [] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0035435 ! phosphate ion transmembrane transport + +[Term] +id: GO:1905012 +name: regulation of 'de novo' NAD biosynthetic process from tryptophan +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] +synonym: "regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +is_a: GO:0030808 ! regulation of nucleotide biosynthetic process +is_a: GO:0090357 ! regulation of tryptophan metabolic process +relationship: regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan + +[Term] +id: GO:1905013 +name: negative regulation of 'de novo' NAD biosynthetic process from tryptophan +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] +synonym: "down regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "down regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "down-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "down-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "downregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "downregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "inhibition of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie] +synonym: "inhibition of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "negative regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +is_a: GO:0030809 ! negative regulation of nucleotide biosynthetic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan +relationship: negatively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan + +[Term] +id: GO:1905014 +name: positive regulation of 'de novo' NAD biosynthetic process from tryptophan +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of 'de novo' NAD biosynthetic process from tryptophan" NARROW [GOC:TermGenie] +synonym: "activation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "positive regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "up regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "up regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "up-regulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "up-regulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +synonym: "upregulation of 'de novo' NAD biosynthetic process from tryptophan" EXACT [GOC:TermGenie] +synonym: "upregulation of de novo NAD biosynthetic process from tryptophan" RELATED [GOC:TermGenie] +is_a: GO:0030810 ! positive regulation of nucleotide biosynthetic process +is_a: GO:0090358 ! positive regulation of tryptophan metabolic process +is_a: GO:1905012 ! regulation of 'de novo' NAD biosynthetic process from tryptophan +relationship: positively_regulates GO:0034354 ! 'de novo' NAD biosynthetic process from tryptophan + +[Term] +id: GO:1905015 +name: regulation of isoleucine-tRNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1905016 +name: negative regulation of isoleucine-tRNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "down regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "inhibition of isoleucine translase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "negative regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity + +[Term] +id: GO:1905017 +name: positive regulation of isoleucine-tRNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of isoleucine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "activation of isoleucine translase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucine-transfer RNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucine-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of isoleucyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-isoleucine:tRNAIle ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "positive regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucine translase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucine-transfer RNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucine-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of isoleucyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [GOC:TermGenie] +is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905015 ! regulation of isoleucine-tRNA ligase activity + +[Term] +id: GO:1905018 +name: regulation of methionine-tRNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of MetRS activity" EXACT [GOC:TermGenie] +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1905019 +name: negative regulation of methionine-tRNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "down regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "inhibition of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of methionine translase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methionine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of MetRS activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of MetRS activity" EXACT [GOC:TermGenie] +is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity + +[Term] +id: GO:1905020 +name: positive regulation of methionine-tRNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of methionine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:1665486] +synonym: "activation of L-methionine:tRNAMet ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "activation of methionine translase activity" NARROW [GOC:TermGenie] +synonym: "activation of methionine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of methionyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of methionyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of methionyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of methionyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of MetRS activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of MetRS activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-methionine:tRNAMet ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of methionine translase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methionine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methionyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methionyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methionyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of methionyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of MetRS activity" EXACT [GOC:TermGenie] +is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905018 ! regulation of methionine-tRNA ligase activity + +[Term] +id: GO:1905021 +name: regulation of threonine-tRNA ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] +synonym: "regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of TRS" RELATED [GOC:TermGenie] +is_a: GO:1903630 ! regulation of aminoacyl-tRNA ligase activity + +[Term] +id: GO:1905022 +name: negative regulation of threonine-tRNA ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] +synonym: "down regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of TRS" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of TRS" RELATED [GOC:TermGenie] +synonym: "downregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of TRS" RELATED [GOC:TermGenie] +synonym: "inhibition of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of threonine translase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of TRS" RELATED [GOC:TermGenie] +synonym: "negative regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of TRS" RELATED [GOC:TermGenie] +is_a: GO:1903631 ! negative regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity + +[Term] +id: GO:1905023 +name: positive regulation of threonine-tRNA ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of threonine-tRNA ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:8049265] +synonym: "activation of L-threonine:tRNAThr ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "activation of threonine translase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonine-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonine-tRNA ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonyl ribonucleic synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonyl-transfer ribonucleate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonyl-transfer ribonucleic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonyl-transfer RNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of threonyl-tRNA synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of TRS" RELATED [GOC:TermGenie] +synonym: "positive regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of TRS" RELATED [GOC:TermGenie] +synonym: "up regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of TRS" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of TRS" RELATED [GOC:TermGenie] +synonym: "upregulation of L-threonine:tRNAThr ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of threonine translase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonine-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonine-tRNA ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonyl ribonucleic synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonyl-transfer ribonucleate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonyl-transfer ribonucleic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonyl-transfer RNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of threonyl-tRNA synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of TRS" RELATED [GOC:TermGenie] +is_a: GO:1903632 ! positive regulation of aminoacyl-tRNA ligase activity +is_a: GO:1905021 ! regulation of threonine-tRNA ligase activity + +[Term] +id: GO:1905024 +name: regulation of membrane repolarization during ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] +synonym: "regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "regulation of ventricular repolarization" RELATED [GOC:TermGenie] +is_a: GO:0060307 ! regulation of ventricular cardiac muscle cell membrane repolarization +is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential +relationship: regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential + +[Term] +id: GO:1905025 +name: negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] +synonym: "down regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "down regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "down regulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "down-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "down-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "down-regulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "downregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "downregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "downregulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "inhibition of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "inhibition of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "inhibition of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "negative regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "negative regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "negative regulation of ventricular repolarization" RELATED [GOC:TermGenie] +is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential +is_a: GO:1905032 ! negative regulation of membrane repolarization during cardiac muscle cell action potential +relationship: negatively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential + +[Term] +id: GO:1905026 +name: positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during ventricular cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19893015] +synonym: "activation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "activation of membrane repolarization during ventricular cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "activation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "positive regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "positive regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "positive regulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "up regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "up regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "up regulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "up-regulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "up-regulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "up-regulation of ventricular repolarization" RELATED [GOC:TermGenie] +synonym: "upregulation of electrocardiogram T wave" RELATED [GOC:TermGenie] +synonym: "upregulation of membrane repolarization during ventricular cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of regulation of ventricular cardiac muscle repolarization" RELATED [GOC:TermGenie] +synonym: "upregulation of ventricular repolarization" RELATED [GOC:TermGenie] +is_a: GO:1905024 ! regulation of membrane repolarization during ventricular cardiac muscle cell action potential +is_a: GO:1905033 ! positive regulation of membrane repolarization during cardiac muscle cell action potential +relationship: positively_regulates GO:0098915 ! membrane repolarization during ventricular cardiac muscle cell action potential + +[Term] +id: GO:1905027 +name: regulation of membrane depolarization during AV node cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] +synonym: "regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0098904 ! regulation of AV node cell action potential +is_a: GO:1900825 ! regulation of membrane depolarization during cardiac muscle cell action potential +relationship: regulates GO:0086045 ! membrane depolarization during AV node cell action potential + +[Term] +id: GO:1905028 +name: negative regulation of membrane depolarization during AV node cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] +synonym: "down regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "inhibition of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] +synonym: "negative regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "negative regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1900826 ! negative regulation of membrane depolarization during cardiac muscle cell action potential +is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential +relationship: negatively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential + +[Term] +id: GO:1905029 +name: positive regulation of membrane depolarization during AV node cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane depolarization during AV node cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:19726871] +synonym: "activation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of membrane depolarization during AV node cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "activation of membrane depolarization during AV node cell action potential" NARROW [GOC:TermGenie] +synonym: "positive regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "positive regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane depolarization during AV node cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane depolarization during AV node cell action potential" EXACT [GOC:TermGenie] +is_a: GO:1900827 ! positive regulation of membrane depolarization during cardiac muscle cell action potential +is_a: GO:1905027 ! regulation of membrane depolarization during AV node cell action potential +relationship: positively_regulates GO:0086045 ! membrane depolarization during AV node cell action potential + +[Term] +id: GO:1905030 +name: voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential +namespace: molecular_function +def: "Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential." [GO_REF:0000061, GOC:TermGenie, ISBN:9780071120005] +subset: goslim_synapse +synonym: "voltage gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] +synonym: "voltage gated ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] +synonym: "voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] +synonym: "voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential" EXACT [GOC:TermGenie] +synonym: "voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential" EXACT [GOC:TermGenie] +is_a: GO:0005244 ! voltage-gated ion channel activity + +[Term] +id: GO:1905031 +name: regulation of membrane repolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] +is_a: GO:0098903 ! regulation of membrane repolarization during action potential +is_a: GO:0099623 ! regulation of cardiac muscle cell membrane repolarization +relationship: regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential + +[Term] +id: GO:1905032 +name: negative regulation of membrane repolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] +synonym: "down regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] +is_a: GO:0034766 ! negative regulation of ion transmembrane transport +is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential +relationship: negatively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential + +[Term] +id: GO:1905033 +name: positive regulation of membrane repolarization during cardiac muscle cell action potential +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane repolarization during cardiac muscle cell action potential." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:mtg_cardiac_conduct_nov11, GOC:rph, GOC:TermGenie, PMID:23157812] +synonym: "activation of membrane repolarization during cardiac muscle cell action potential" NARROW [GOC:TermGenie] +synonym: "up regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane repolarization during cardiac muscle cell action potential" EXACT [GOC:TermGenie] +is_a: GO:0034767 ! positive regulation of ion transmembrane transport +is_a: GO:1905031 ! regulation of membrane repolarization during cardiac muscle cell action potential +relationship: positively_regulates GO:0086013 ! membrane repolarization during cardiac muscle cell action potential + +[Term] +id: GO:1905034 +name: regulation of antifungal innate immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] +is_a: GO:0045088 ! regulation of innate immune response +is_a: GO:1900150 ! regulation of defense response to fungus +relationship: regulates GO:0061760 ! antifungal innate immune response + +[Term] +id: GO:1905035 +name: negative regulation of antifungal innate immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] +synonym: "down regulation of antifungal innate immune response" EXACT [GOC:TermGenie] +synonym: "down-regulation of antifungal innate immune response" EXACT [GOC:TermGenie] +synonym: "downregulation of antifungal innate immune response" EXACT [GOC:TermGenie] +synonym: "inhibition of antifungal innate immune response" NARROW [GOC:TermGenie] +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:1905034 ! regulation of antifungal innate immune response +relationship: negatively_regulates GO:0061760 ! antifungal innate immune response + +[Term] +id: GO:1905036 +name: positive regulation of antifungal innate immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:22470487] +synonym: "activation of antifungal innate immune response" NARROW [GOC:TermGenie] +synonym: "up regulation of antifungal innate immune response" EXACT [GOC:TermGenie] +synonym: "up-regulation of antifungal innate immune response" EXACT [GOC:TermGenie] +synonym: "upregulation of antifungal innate immune response" EXACT [GOC:TermGenie] +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:1905034 ! regulation of antifungal innate immune response +relationship: positively_regulates GO:0061760 ! antifungal innate immune response + +[Term] +id: GO:1905037 +name: autophagosome organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] +synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] +synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] +is_a: GO:0007033 ! vacuole organization +relationship: part_of GO:0016236 ! macroautophagy + +[Term] +id: GO:1905038 +name: regulation of membrane lipid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:25954280] +synonym: "regulation of membrane lipid metabolism" EXACT [GOC:TermGenie] +is_a: GO:0019216 ! regulation of lipid metabolic process +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0006643 ! membrane lipid metabolic process + +[Term] +id: GO:1905039 +name: carboxylic acid transmembrane transport +namespace: biological_process +def: "The process in which carboxylic acid is transported across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:10869563] +is_a: GO:1903825 ! organic acid transmembrane transport + +[Term] +id: GO:1905040 +name: otic placode development +namespace: biological_process +def: "The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure." [GO_REF:0000094, GOC:bf, GOC:mat, GOC:PARL, GOC:TermGenie, PMID:18356247] +synonym: "auditory placode development" RELATED [GOC:TermGenie] +synonym: "ear placode development" RELATED [GOC:TermGenie] +synonym: "ear/otic placode development" RELATED [GOC:TermGenie] +synonym: "octaval placode development" RELATED [GOC:TermGenie] +synonym: "octaval VIII placode development" RELATED [GOC:TermGenie] +synonym: "placoda otica development" EXACT [GOC:TermGenie] +is_a: GO:0071696 ! ectodermal placode development + +[Term] +id: GO:1905041 +name: regulation of epithelium regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] +synonym: "regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:1990399 ! epithelium regeneration + +[Term] +id: GO:1905042 +name: negative regulation of epithelium regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] +synonym: "down regulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "down regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelium regeneration" NARROW [GOC:TermGenie] +synonym: "inhibition of regeneration of epithelium" NARROW [GOC:TermGenie] +synonym: "negative regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1905041 ! regulation of epithelium regeneration +relationship: negatively_regulates GO:1990399 ! epithelium regeneration + +[Term] +id: GO:1905043 +name: positive regulation of epithelium regeneration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelium regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23221517] +synonym: "activation of epithelium regeneration" NARROW [GOC:TermGenie] +synonym: "activation of regeneration of epithelium" NARROW [GOC:TermGenie] +synonym: "positive regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "up regulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "up regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of regeneration of epithelium" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelium regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of regeneration of epithelium" EXACT [GOC:TermGenie] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1905041 ! regulation of epithelium regeneration +relationship: positively_regulates GO:1990399 ! epithelium regeneration + +[Term] +id: GO:1905044 +name: regulation of Schwann cell proliferation involved in axon regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] +is_a: GO:0010624 ! regulation of Schwann cell proliferation +relationship: regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration + +[Term] +id: GO:1905045 +name: negative regulation of Schwann cell proliferation involved in axon regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] +synonym: "down regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "inhibition of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie] +is_a: GO:0010626 ! negative regulation of Schwann cell proliferation +is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration +relationship: negatively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration + +[Term] +id: GO:1905046 +name: positive regulation of Schwann cell proliferation involved in axon regeneration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Schwann cell proliferation involved in axon regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22393241] +synonym: "activation of Schwann cell proliferation involved in axon regeneration" NARROW [GOC:TermGenie] +synonym: "up regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of Schwann cell proliferation involved in axon regeneration" EXACT [GOC:TermGenie] +is_a: GO:0010625 ! positive regulation of Schwann cell proliferation +is_a: GO:1905044 ! regulation of Schwann cell proliferation involved in axon regeneration +relationship: positively_regulates GO:0014011 ! Schwann cell proliferation involved in axon regeneration + +[Term] +id: GO:1905047 +name: mitotic spindle pole body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body." [GOC:TermGenie, PMID:24963130] +is_a: GO:0051300 ! spindle pole body organization + +[Term] +id: GO:1905048 +name: regulation of metallopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] +synonym: "regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:1905049 +name: negative regulation of metallopeptidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] +synonym: "down regulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "down regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "downregulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metallopeptidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "inhibition of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:1905048 ! regulation of metallopeptidase activity + +[Term] +id: GO:1905050 +name: positive regulation of metallopeptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metallopeptidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26473732] +synonym: "activation of metallopeptidase activity" NARROW [GOC:TermGenie] +synonym: "activation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "activation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "up regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of metalloproteinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of metallopeptidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of metalloprotease activity" NARROW [GOC:TermGenie] +synonym: "upregulation of metalloproteinase activity" NARROW [GOC:TermGenie] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:1905048 ! regulation of metallopeptidase activity + +[Term] +id: GO:1905051 +name: regulation of base-excision repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] +synonym: "regulation of BER" EXACT [GOC:TermGenie] +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0006284 ! base-excision repair + +[Term] +id: GO:1905052 +name: negative regulation of base-excision repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] +synonym: "down regulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "down regulation of BER" EXACT [GOC:TermGenie] +synonym: "down-regulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of BER" EXACT [GOC:TermGenie] +synonym: "downregulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "downregulation of BER" EXACT [GOC:TermGenie] +synonym: "inhibition of base-excision repair" NARROW [GOC:TermGenie] +synonym: "inhibition of BER" NARROW [GOC:TermGenie] +synonym: "negative regulation of BER" EXACT [GOC:TermGenie] +is_a: GO:0045738 ! negative regulation of DNA repair +is_a: GO:1905051 ! regulation of base-excision repair +relationship: negatively_regulates GO:0006284 ! base-excision repair + +[Term] +id: GO:1905053 +name: positive regulation of base-excision repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of base-excision repair." [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764] +synonym: "activation of base-excision repair" NARROW [GOC:TermGenie] +synonym: "activation of BER" NARROW [GOC:TermGenie] +synonym: "positive regulation of BER" EXACT [GOC:TermGenie] +synonym: "up regulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "up regulation of BER" EXACT [GOC:TermGenie] +synonym: "up-regulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of BER" EXACT [GOC:TermGenie] +synonym: "upregulation of base-excision repair" EXACT [GOC:TermGenie] +synonym: "upregulation of BER" EXACT [GOC:TermGenie] +is_a: GO:0045739 ! positive regulation of DNA repair +is_a: GO:1905051 ! regulation of base-excision repair +relationship: positively_regulates GO:0006284 ! base-excision repair + +[Term] +id: GO:1905054 +name: calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:15919193, PMID:23918386] +subset: goslim_synapse +synonym: "calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0048763 ! calcium-induced calcium release activity + +[Term] +id: GO:1905055 +name: calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962, PMID:23255722] +subset: goslim_synapse +synonym: "calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0015368 ! calcium:cation antiporter activity + +[Term] +id: GO:1905056 +name: P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:22972962] +subset: goslim_synapse +synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [] +synonym: "plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +is_a: GO:0005388 ! P-type calcium transporter activity + +[Term] +id: GO:1905057 +name: voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels +namespace: molecular_function +def: "Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20734177] +subset: goslim_synapse +synonym: "depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +is_a: GO:0099511 ! voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels + +[Term] +id: GO:1905058 +name: calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:23639769] +subset: goslim_synapse +synonym: "calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +is_a: GO:0048763 ! calcium-induced calcium release activity + +[Term] +id: GO:1905059 +name: P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "A calcium-transporting P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:20678993] +subset: goslim_synapse +synonym: "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration" EXACT [] +synonym: "calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels" EXACT syngo_official_label [] +synonym: "plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +synonym: "sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration" NARROW [GOC:TermGenie] +is_a: GO:0005388 ! P-type calcium transporter activity + +[Term] +id: GO:1905060 +name: calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration +namespace: molecular_function +def: "Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration." [GO_REF:0000061, GOC:TermGenie, PMID:18024055] +subset: goslim_synapse +synonym: "calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels" EXACT syngo_official_label [] +is_a: GO:0015368 ! calcium:cation antiporter activity + +[Term] +id: GO:1905061 +name: negative regulation of cardioblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097] +synonym: "down regulation of cardioblast proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardioblast proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of cardioblast proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of cardioblast proliferation" NARROW [GOC:TermGenie] +is_a: GO:0003264 ! regulation of cardioblast proliferation +is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis +relationship: negatively_regulates GO:0003263 ! cardioblast proliferation + +[Term] +id: GO:1905062 +name: positive regulation of cardioblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardioblast proliferation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:24236097] +synonym: "activation of cardioblast proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of cardioblast proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardioblast proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of cardioblast proliferation" EXACT [GOC:TermGenie] +is_a: GO:0003264 ! regulation of cardioblast proliferation +is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis +relationship: positively_regulates GO:0003263 ! cardioblast proliferation + +[Term] +id: GO:1905063 +name: regulation of vascular associated smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of VSMC differentiation" EXACT [GOC:TermGenie] +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: regulates GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:1905064 +name: negative regulation of vascular associated smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "down regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of VSMC differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of VSMC differentiation" EXACT [GOC:TermGenie] +is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation +relationship: negatively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:1905065 +name: positive regulation of vascular associated smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "activation of vascular associated smooth muscle cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of VSMC differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of VSMC differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of VSMC differentiation" EXACT [GOC:TermGenie] +is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation +relationship: positively_regulates GO:0035886 ! vascular associated smooth muscle cell differentiation + +[Term] +id: GO:1905066 +name: regulation of canonical Wnt signaling pathway involved in heart development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development + +[Term] +id: GO:1905067 +name: negative regulation of canonical Wnt signaling pathway involved in heart development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] +synonym: "down regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development +relationship: negatively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development + +[Term] +id: GO:1905068 +name: positive regulation of canonical Wnt signaling pathway involved in heart development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25034767] +synonym: "activation of canonical Wnt receptor signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt receptor signalling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt-activated signaling pathway involved in heart development" NARROW [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt-activated signaling pathway involved in heart development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway +is_a: GO:1905066 ! regulation of canonical Wnt signaling pathway involved in heart development +relationship: positively_regulates GO:0061316 ! canonical Wnt signaling pathway involved in heart development + +[Term] +id: GO:1905069 +name: allantois development +namespace: biological_process +def: "The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:17440924, PMID:21470579] +synonym: "allantoic bud development" RELATED [GOC:TermGenie] +is_a: GO:1903867 ! extraembryonic membrane development + +[Term] +id: GO:1905070 +name: anterior visceral endoderm cell migration +namespace: biological_process +def: "The orderly movement of an anterior visceral endoderm cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:17078044] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:1905071 +name: tight junction disassembly +namespace: biological_process +def: "The disaggregation of an tight junction into its constituent components." [GO_REF:0000079, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "occluding junction disassembly" EXACT [] +is_a: GO:0120193 ! tight junction organization +is_a: GO:0150147 ! cell-cell junction disassembly + +[Term] +id: GO:1905072 +name: cardiac jelly development +namespace: biological_process +def: "The process whose specific outcome is the progression of cardiac jelly over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439] +synonym: "heart cardiac jelly development" EXACT [GOC:TermGenie] +is_a: GO:0009888 ! tissue development + +[Term] +id: GO:1905073 +name: regulation of tight junction disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "regulation of occluding junction disassembly" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:1905071 ! tight junction disassembly + +[Term] +id: GO:1905074 +name: negative regulation of tight junction disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "down regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "down regulation of tight junction disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of tight junction disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of occluding junction disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of tight junction disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of occluding cell junction disassembly" NARROW [GOC:TermGenie] +synonym: "inhibition of occluding junction disassembly" NARROW [GOC:TermGenie] +synonym: "inhibition of tight junction disassembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1905073 ! regulation of tight junction disassembly +relationship: negatively_regulates GO:1905071 ! tight junction disassembly + +[Term] +id: GO:1905075 +name: positive regulation of tight junction disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tight junction disassembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "activation of occluding cell junction disassembly" NARROW [GOC:TermGenie] +synonym: "activation of occluding junction disassembly" NARROW [GOC:TermGenie] +synonym: "activation of tight junction disassembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of occluding junction disassembly" EXACT [GOC:TermGenie] +synonym: "up regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "up regulation of tight junction disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of tight junction disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of occluding cell junction disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of tight junction disassembly" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905073 ! regulation of tight junction disassembly +relationship: positively_regulates GO:1905071 ! tight junction disassembly + +[Term] +id: GO:1905079 +name: regulation of cerebellar neuron development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] +is_a: GO:0045664 ! regulation of neuron differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0098749 ! cerebellar neuron development + +[Term] +id: GO:1905080 +name: negative regulation of cerebellar neuron development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] +synonym: "down regulation of cerebellar neuron development" EXACT [GOC:TermGenie] +synonym: "down-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] +synonym: "downregulation of cerebellar neuron development" EXACT [GOC:TermGenie] +synonym: "inhibition of cerebellar neuron development" NARROW [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:1905079 ! regulation of cerebellar neuron development +relationship: negatively_regulates GO:0098749 ! cerebellar neuron development + +[Term] +id: GO:1905081 +name: positive regulation of cerebellar neuron development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cerebellar neuron development." [GO_REF:0000058, GOC:TermGenie, PMID:26609159] +synonym: "activation of cerebellar neuron development" NARROW [GOC:TermGenie] +synonym: "up regulation of cerebellar neuron development" EXACT [GOC:TermGenie] +synonym: "up-regulation of cerebellar neuron development" EXACT [GOC:TermGenie] +synonym: "upregulation of cerebellar neuron development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:1905079 ! regulation of cerebellar neuron development +relationship: positively_regulates GO:0098749 ! cerebellar neuron development + +[Term] +id: GO:1905082 +name: regulation of mitochondrial translational elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] +synonym: "regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +is_a: GO:0006448 ! regulation of translational elongation +relationship: regulates GO:0070125 ! mitochondrial translational elongation + +[Term] +id: GO:1905083 +name: negative regulation of mitochondrial translational elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] +synonym: "down regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "down regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial translation elongation" NARROW [GOC:TermGenie] +synonym: "inhibition of mitochondrial translational elongation" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +is_a: GO:0045900 ! negative regulation of translational elongation +is_a: GO:0070130 ! negative regulation of mitochondrial translation +is_a: GO:1905082 ! regulation of mitochondrial translational elongation +relationship: negatively_regulates GO:0070125 ! mitochondrial translational elongation + +[Term] +id: GO:1905084 +name: positive regulation of mitochondrial translational elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translational elongation." [GO_REF:0000058, GOC:TermGenie, PMID:25738458] +synonym: "activation of mitochondrial translation elongation" NARROW [GOC:TermGenie] +synonym: "activation of mitochondrial translational elongation" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial translation elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial translational elongation" EXACT [GOC:TermGenie] +is_a: GO:0045901 ! positive regulation of translational elongation +is_a: GO:1905082 ! regulation of mitochondrial translational elongation +relationship: positively_regulates GO:0070125 ! mitochondrial translational elongation + +[Term] +id: GO:1905085 +name: regulation of bioluminescence +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0008218 ! bioluminescence + +[Term] +id: GO:1905086 +name: negative regulation of bioluminescence +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] +synonym: "down regulation of bioluminescence" EXACT [GOC:TermGenie] +synonym: "down-regulation of bioluminescence" EXACT [GOC:TermGenie] +synonym: "downregulation of bioluminescence" EXACT [GOC:TermGenie] +synonym: "inhibition of bioluminescence" NARROW [GOC:TermGenie] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:1905085 ! regulation of bioluminescence +relationship: negatively_regulates GO:0008218 ! bioluminescence + +[Term] +id: GO:1905087 +name: positive regulation of bioluminescence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of bioluminescence." [GO_REF:0000058, GOC:BHF, GOC:rph, GOC:TermGenie, PMID:10913092] +synonym: "activation of bioluminescence" NARROW [GOC:TermGenie] +synonym: "up regulation of bioluminescence" EXACT [GOC:TermGenie] +synonym: "up-regulation of bioluminescence" EXACT [GOC:TermGenie] +synonym: "upregulation of bioluminescence" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1905085 ! regulation of bioluminescence +relationship: positively_regulates GO:0008218 ! bioluminescence + +[Term] +id: GO:1905088 +name: positive regulation of synaptonemal complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:24797370] +synonym: "activation of synaptonemal complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of synaptonemal complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptonemal complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptonemal complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptonemal complex formation" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0090173 ! regulation of synaptonemal complex assembly +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0007130 ! synaptonemal complex assembly + +[Term] +id: GO:1905089 +name: regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a parkin-mediated process that positively regulates mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] +synonym: "regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +synonym: "regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +is_a: GO:0080135 ! regulation of cellular response to stress +is_a: GO:1901524 ! regulation of mitophagy +relationship: regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + +[Term] +id: GO:1905090 +name: negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] +synonym: "down regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "down-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "downregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "inhibition of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] +synonym: "negative regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +synonym: "negative regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905089 ! regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +relationship: negatively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + +[Term] +id: GO:1905091 +name: positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:26942284] +synonym: "activation of parkin-mediated mitophagy in response to mitochondrial depolarization" NARROW [GOC:TermGenie] +synonym: "positive regulation of Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +synonym: "positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization" EXACT [] +synonym: "up regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "up-regulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +synonym: "upregulation of parkin-mediated mitophagy in response to mitochondrial depolarization" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1901526 ! positive regulation of mitophagy +is_a: GO:1905089 ! regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization +relationship: positively_regulates GO:0061734 ! parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization + +[Term] +id: GO:1905092 +name: response to diosgenin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] +is_a: GO:0036314 ! response to sterol +is_a: GO:0097305 ! response to alcohol +is_a: GO:1905836 ! response to triterpenoid + +[Term] +id: GO:1905093 +name: cellular response to diosgenin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diosgenin stimulus." [GO_REF:0000071, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25765596] +is_a: GO:0036315 ! cellular response to sterol +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1905092 ! response to diosgenin +is_a: GO:1905837 ! cellular response to triterpenoid + +[Term] +id: GO:1905094 +name: regulation of apolipoprotein A-I-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] +synonym: "regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway + +[Term] +id: GO:1905095 +name: negative regulation of apolipoprotein A-I-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] +synonym: "down regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway +relationship: negatively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway + +[Term] +id: GO:1905096 +name: positive regulation of apolipoprotein A-I-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25084135] +synonym: "activation of apolipoprotein A-I-mediated signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of apolipoprotein A-I-mediated signalling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of apolipoprotein A-I-mediated signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of apolipoprotein A-I-mediated signalling pathway" EXACT [GOC:TermGenie] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:1905094 ! regulation of apolipoprotein A-I-mediated signaling pathway +relationship: positively_regulates GO:0038027 ! apolipoprotein A-I-mediated signaling pathway + +[Term] +id: GO:1905097 +name: regulation of guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] +synonym: "regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "regulation of GDS" EXACT [GOC:TermGenie] +synonym: "regulation of GEF" EXACT [GOC:TermGenie] +synonym: "regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +is_a: GO:0043087 ! regulation of GTPase activity +is_a: GO:1904424 ! regulation of GTP binding + +[Term] +id: GO:1905098 +name: negative regulation of guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] +synonym: "down regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "down regulation of GDS" EXACT [GOC:TermGenie] +synonym: "down regulation of GEF" EXACT [GOC:TermGenie] +synonym: "down regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "down regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "down regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "down-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of GDS" EXACT [GOC:TermGenie] +synonym: "down-regulation of GEF" EXACT [GOC:TermGenie] +synonym: "down-regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "down-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "downregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "downregulation of GDS" EXACT [GOC:TermGenie] +synonym: "downregulation of GEF" EXACT [GOC:TermGenie] +synonym: "downregulation of GNRP" NARROW [GOC:TermGenie] +synonym: "downregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "inhibition of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GDS" NARROW [GOC:TermGenie] +synonym: "inhibition of GEF" NARROW [GOC:TermGenie] +synonym: "inhibition of GNRP" NARROW [GOC:TermGenie] +synonym: "inhibition of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie] +synonym: "inhibition of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie] +synonym: "negative regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of GDS" EXACT [GOC:TermGenie] +synonym: "negative regulation of GEF" EXACT [GOC:TermGenie] +synonym: "negative regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "negative regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity + +[Term] +id: GO:1905099 +name: positive regulation of guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity." [GO_REF:0000059, GOC:TermGenie, PMID:20484009] +synonym: "activation of GDP-dissociation stimulator activity" NARROW [GOC:TermGenie] +synonym: "activation of GDS" NARROW [GOC:TermGenie] +synonym: "activation of GEF" NARROW [GOC:TermGenie] +synonym: "activation of GNRP" NARROW [GOC:TermGenie] +synonym: "activation of guanyl-nucleotide exchange factor activity" NARROW [GOC:TermGenie] +synonym: "activation of guanyl-nucleotide release factor activity" NARROW [GOC:TermGenie] +synonym: "activation of guanyl-nucleotide releasing factor" NARROW [GOC:TermGenie] +synonym: "positive regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of GDS" EXACT [GOC:TermGenie] +synonym: "positive regulation of GEF" EXACT [GOC:TermGenie] +synonym: "positive regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "positive regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "up regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "up regulation of GDS" EXACT [GOC:TermGenie] +synonym: "up regulation of GEF" EXACT [GOC:TermGenie] +synonym: "up regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "up regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "up regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "up-regulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of GDS" EXACT [GOC:TermGenie] +synonym: "up-regulation of GEF" EXACT [GOC:TermGenie] +synonym: "up-regulation of GNRP" NARROW [GOC:TermGenie] +synonym: "up-regulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +synonym: "upregulation of GDP-dissociation stimulator activity" EXACT [GOC:TermGenie] +synonym: "upregulation of GDS" EXACT [GOC:TermGenie] +synonym: "upregulation of GEF" EXACT [GOC:TermGenie] +synonym: "upregulation of GNRP" NARROW [GOC:TermGenie] +synonym: "upregulation of guanyl-nucleotide exchange factor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of guanyl-nucleotide release factor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of guanyl-nucleotide releasing factor" EXACT [GOC:TermGenie] +is_a: GO:1904426 ! positive regulation of GTP binding +is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity + +[Term] +id: GO:1905100 +name: regulation of apoptosome assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] +synonym: "regulation of apoptosome formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0097314 ! apoptosome assembly + +[Term] +id: GO:1905101 +name: negative regulation of apoptosome assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] +synonym: "down regulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "inhibition of apoptosome assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of apoptosome formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of apoptosome formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1905100 ! regulation of apoptosome assembly +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +relationship: negatively_regulates GO:0097314 ! apoptosome assembly + +[Term] +id: GO:1905102 +name: positive regulation of apoptosome assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptosome assembly." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:26265044] +synonym: "activation of apoptosome assembly" NARROW [GOC:TermGenie] +synonym: "activation of apoptosome formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of apoptosome formation" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptosome assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of apoptosome formation" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1905100 ! regulation of apoptosome assembly +relationship: positively_regulates GO:0097314 ! apoptosome assembly + +[Term] +id: GO:1905103 +name: integral component of lysosomal membrane +namespace: cellular_component +def: "The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GO_REF:0000064, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26134396] +synonym: "integral component of lysosome membrane" EXACT [GOC:bf] +synonym: "integral to lysosomal membrane" NARROW [] +is_a: GO:0031166 ! integral component of vacuolar membrane +relationship: part_of GO:0005765 ! lysosomal membrane + +[Term] +id: GO:1905104 +name: obsolete response to ouabain +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905105 +name: obsolete cellular response to ouabain +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ouabain stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23643758] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905106 +name: obsolete response to Dizocilpine +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905107 +name: obsolete cellular response to Dizocilpine +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Dizocilpine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:20064280] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905108 +name: guanosine binding +namespace: molecular_function +def: "Binding to guanosine." [GO_REF:0000067, GOC:TermGenie, PMID:26007660] +is_a: GO:0032550 ! purine ribonucleoside binding + +[Term] +id: GO:1905109 +name: regulation of pulmonary blood vessel remodeling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +is_a: GO:0060312 ! regulation of blood vessel remodeling +relationship: regulates GO:0101010 ! pulmonary blood vessel remodeling + +[Term] +id: GO:1905110 +name: negative regulation of pulmonary blood vessel remodeling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +synonym: "down regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +synonym: "down-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +synonym: "downregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +synonym: "inhibition of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] +is_a: GO:0060313 ! negative regulation of blood vessel remodeling +is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling +relationship: negatively_regulates GO:0101010 ! pulmonary blood vessel remodeling + +[Term] +id: GO:1905111 +name: positive regulation of pulmonary blood vessel remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pulmonary blood vessel remodeling." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +synonym: "activation of pulmonary blood vessel remodeling" NARROW [GOC:TermGenie] +synonym: "up regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +synonym: "up-regulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +synonym: "upregulation of pulmonary blood vessel remodeling" EXACT [GOC:TermGenie] +is_a: GO:1905109 ! regulation of pulmonary blood vessel remodeling +is_a: GO:2000504 ! positive regulation of blood vessel remodeling +relationship: positively_regulates GO:0101010 ! pulmonary blood vessel remodeling + +[Term] +id: GO:1905112 +name: obsolete regulation of centromere clustering at the mitotic nuclear envelope +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] +comment: This term was obsoleted because it represented a phenotype. +synonym: "regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] +synonym: "regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "regulation of rabl configuration" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905113 +name: obsolete positive regulation of centromere clustering at the mitotic nuclear envelope +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of centromere clustering at the nuclear envelope." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] +comment: This term was obsoleted because it represented a phenotype. +synonym: "activation of centromere clustering at the nuclear envelope" NARROW [GOC:TermGenie] +synonym: "activation of centromere clustering at the nuclear periphery" NARROW [GOC:TermGenie] +synonym: "activation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "activation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "activation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "activation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "activation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "activation of rabl configuration" RELATED [GOC:TermGenie] +synonym: "positive regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] +synonym: "positive regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "positive regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "positive regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "positive regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "positive regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "positive regulation of rabl configuration" RELATED [GOC:TermGenie] +synonym: "up regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] +synonym: "up regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] +synonym: "up regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "up regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "up regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "up regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "up regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "up regulation of rabl configuration" RELATED [GOC:TermGenie] +synonym: "up-regulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] +synonym: "up-regulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] +synonym: "up-regulation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "up-regulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "up-regulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "up-regulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "up-regulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "up-regulation of rabl configuration" RELATED [GOC:TermGenie] +synonym: "upregulation of centromere clustering at the nuclear envelope" EXACT [GOC:TermGenie] +synonym: "upregulation of centromere clustering at the nuclear periphery" EXACT [GOC:TermGenie] +synonym: "upregulation of centromere-SPB clustering" RELATED [GOC:TermGenie] +synonym: "upregulation of kinetochore clustering at SPB" RELATED [GOC:TermGenie] +synonym: "upregulation of kinetochore clustering at spindle pole body" RELATED [GOC:TermGenie] +synonym: "upregulation of kinetochore clustering at the old mitotic spindle pole body" RELATED [GOC:TermGenie] +synonym: "upregulation of kinetochore localization at spindle pole body" RELATED [GOC:TermGenie] +synonym: "upregulation of rabl configuration" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905114 +name: cell surface receptor signaling pathway involved in cell-cell signaling +namespace: biological_process +def: "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0] +synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] +synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] +is_a: GO:0007166 ! cell surface receptor signaling pathway +relationship: part_of GO:0007267 ! cell-cell signaling + +[Term] +id: GO:1905115 +name: regulation of lateral attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] +is_a: GO:1902423 ! regulation of attachment of mitotic spindle microtubules to kinetochore +relationship: regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1905116 +name: positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lateral attachment of mitotic spindle microtubules to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22375062] +synonym: "activation of lateral attachment of mitotic spindle microtubules to kinetochore" NARROW [GOC:TermGenie] +synonym: "up regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] +synonym: "up-regulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] +synonym: "upregulation of lateral attachment of mitotic spindle microtubules to kinetochore" EXACT [GOC:TermGenie] +is_a: GO:1902425 ! positive regulation of attachment of mitotic spindle microtubules to kinetochore +is_a: GO:1905115 ! regulation of lateral attachment of mitotic spindle microtubules to kinetochore +relationship: positively_regulates GO:0099607 ! lateral attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1905117 +name: regulation of ribonucleoside-diphosphate reductase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891] +comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype). +synonym: "regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "regulation of ribonucleotide diphosphate reductase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ribonucleotide reductase activity" BROAD [GOC:TermGenie] +synonym: "regulation of RNR" RELATED [GOC:TermGenie] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:1905118 +name: positive regulation of ribonucleoside-diphosphate reductase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity." [GO_REF:0000059, GOC:bhm, GOC:TermGenie, PMID:24733891] +comment: An example of this is DRE2 in Saccharomyces cerevisiae (UniProt ID P36152) in PMID:24733891 (inferred from mutant phenotype). +synonym: "activation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "activation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "activation of RNR" RELATED [GOC:TermGenie] +synonym: "positive regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "positive regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "positive regulation of RNR" RELATED [GOC:TermGenie] +synonym: "up regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "up regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of RNR" RELATED [GOC:TermGenie] +synonym: "up-regulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "up-regulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of RNR" RELATED [GOC:TermGenie] +synonym: "upregulation of adenosylcobalamin-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of aerobic non-heme iron-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of anaerobic iron-sulfur-dependent ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of class I ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of class II ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of class II ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of class III ribonucleotide reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of nucleoside diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of purine/pyrimidine nucleoside diphosphate reduction" RELATED [GOC:TermGenie] +synonym: "upregulation of ribonucleoside 5'-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of ribonucleoside-diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of ribonucleotide diphosphate reductase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of RNR" RELATED [GOC:TermGenie] +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:1905117 ! regulation of ribonucleoside-diphosphate reductase activity + +[Term] +id: GO:1905119 +name: response to haloperidol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0097305 ! response to alcohol +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1905120 +name: cellular response to haloperidol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus." [GO_REF:0000071, GOC:dw, GOC:TermGenie, PMID:24751813] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:0097306 ! cellular response to alcohol +is_a: GO:1901655 ! cellular response to ketone +is_a: GO:1905119 ! response to haloperidol + +[Term] +id: GO:1905123 +name: regulation of glucosylceramidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] +synonym: "regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of GCase activity" EXACT [PMID:24334770] +synonym: "regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1905124 +name: negative regulation of glucosylceramidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of acid beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of beta-glucosylceramidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ceramide glucosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucosylceramidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucosylcerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of psychosine hydrolase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of GCase activity" EXACT [PMID:24334770] +synonym: "negative regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0051346 ! negative regulation of hydrolase activity +is_a: GO:1905123 ! regulation of glucosylceramidase activity + +[Term] +id: GO:1905125 +name: positive regulation of glucosylceramidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucosylceramidase activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of acid beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-D-glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of beta-glucosylceramidase activity" NARROW [GOC:TermGenie] +synonym: "activation of ceramide glucosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of D-glucosyl-N-acylsphingosine glucohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of GlcCer-beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucocerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucosphingosine glucosylhydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucosylceramidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucosylcerebrosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucosylsphingosine beta-D-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of glucosylsphingosine beta-glucosidase activity" NARROW [GOC:TermGenie] +synonym: "activation of psychosine hydrolase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of GCase activity" EXACT [PMID:24334770] +synonym: "positive regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of acid beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-D-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of beta-glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ceramide glucosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of GlcCer-beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucocerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucosphingosine glucosylhydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucosylceramidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucosylcerebrosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucosylsphingosine beta-D-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glucosylsphingosine beta-glucosidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of psychosine hydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1905123 ! regulation of glucosylceramidase activity + +[Term] +id: GO:1905126 +name: regulation of axo-dendritic protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] +synonym: "regulation of axonal protein transport" NARROW [GOC:TermGenie] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0099640 ! axo-dendritic protein transport + +[Term] +id: GO:1905127 +name: negative regulation of axo-dendritic protein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] +synonym: "down regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "down regulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "down-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "downregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "downregulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "inhibition of axo-dendritic protein transport" NARROW [GOC:TermGenie] +synonym: "inhibition of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of axonal protein transport" NARROW [GOC:TermGenie] +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1905126 ! regulation of axo-dendritic protein transport +relationship: negatively_regulates GO:0099640 ! axo-dendritic protein transport + +[Term] +id: GO:1905128 +name: positive regulation of axo-dendritic protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:20694152] +synonym: "activation of axo-dendritic protein transport" NARROW [GOC:TermGenie] +synonym: "activation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "up regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "up regulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "up-regulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of axonal protein transport" NARROW [GOC:TermGenie] +synonym: "upregulation of axo-dendritic protein transport" EXACT [GOC:TermGenie] +synonym: "upregulation of axonal protein transport" NARROW [GOC:TermGenie] +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1905126 ! regulation of axo-dendritic protein transport +relationship: positively_regulates GO:0099640 ! axo-dendritic protein transport + +[Term] +id: GO:1905129 +name: endocannabinoid signaling pathway involved in trans-synaptic signaling +namespace: biological_process +def: "Any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807] +synonym: "endocannabinoid signalling pathway involved in trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie] +is_a: GO:0071926 ! endocannabinoid signaling pathway +relationship: part_of GO:0099542 ! trans-synaptic signaling by endocannabinoid + +[Term] +id: GO:1905130 +name: carcinine import across plasma membrane +namespace: biological_process +def: "The directed movement of carcinine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872] +is_a: GO:0042886 ! amide transport +is_a: GO:0045117 ! azole transmembrane transport +is_a: GO:0072337 ! modified amino acid transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane + +[Term] +id: GO:1905131 +name: carcinine transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of carcinine from one side of a membrane to the other." [GO_REF:0000070, GOC:dph, GOC:TermGenie, PMID:26653853, PMID:26713872] +is_a: GO:0042887 ! amide transmembrane transporter activity +is_a: GO:0072349 ! modified amino acid transmembrane transporter activity +is_a: GO:1901474 ! azole transmembrane transporter activity + +[Term] +id: GO:1905132 +name: regulation of meiotic chromosome separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] +synonym: "regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +is_a: GO:1905818 ! regulation of chromosome separation +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:1905133 +name: negative regulation of meiotic chromosome separation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] +synonym: "down regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "down regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "down regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +synonym: "downregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +synonym: "inhibition of chromosome separation during meiosis" NARROW [GOC:TermGenie] +synonym: "inhibition of meiotic chromosome resolution" NARROW [GOC:TermGenie] +synonym: "inhibition of meiotic chromosome separation" NARROW [GOC:TermGenie] +synonym: "negative regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +is_a: GO:1905132 ! regulation of meiotic chromosome separation +is_a: GO:1905819 ! negative regulation of chromosome separation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:1905134 +name: positive regulation of meiotic chromosome separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation." [GO_REF:0000058, GOC:TermGenie, GOC:vw, PMID:15620645] +synonym: "activation of chromosome separation during meiosis" NARROW [GOC:TermGenie] +synonym: "activation of meiotic chromosome resolution" NARROW [GOC:TermGenie] +synonym: "activation of meiotic chromosome separation" NARROW [GOC:TermGenie] +synonym: "positive regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "up regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "up regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "up regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +synonym: "upregulation of chromosome separation during meiosis" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic chromosome resolution" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic chromosome separation" EXACT [GOC:TermGenie] +is_a: GO:1905132 ! regulation of meiotic chromosome separation +is_a: GO:1905820 ! positive regulation of chromosome separation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0051307 ! meiotic chromosome separation + +[Term] +id: GO:1905135 +name: biotin import across plasma membrane +namespace: biological_process +alt_id: GO:0044756 +alt_id: GO:1901689 +def: "The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275] +synonym: "biotin import" RELATED [] +synonym: "biotin import into cell" EXACT [] +is_a: GO:0015878 ! biotin transport +is_a: GO:0035461 ! vitamin transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1905136 +name: dethiobiotin import across plasma membrane +namespace: biological_process +alt_id: GO:0044757 +alt_id: GO:1901690 +def: "The directed movement of dethiobiotin from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:12557275] +synonym: "dethiobiotin import" RELATED [] +synonym: "dethiobiotin import into cell" EXACT [] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0042886 ! amide transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:0098657 ! import into cell +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1905137 +name: regulation of viral DNA genome packaging via site-specific sequence recognition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378] +is_a: GO:1903900 ! regulation of viral life cycle +relationship: regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition + +[Term] +id: GO:1905138 +name: positive regulation of viral DNA genome packaging via site-specific sequence recognition +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition." [GO_REF:0000058, GOC:TermGenie, PMID:24711378] +synonym: "activation of viral DNA genome packaging via site-specific sequence recognition" NARROW [GOC:TermGenie] +synonym: "up regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] +synonym: "up-regulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] +synonym: "upregulation of viral DNA genome packaging via site-specific sequence recognition" EXACT [GOC:TermGenie] +is_a: GO:1903902 ! positive regulation of viral life cycle +is_a: GO:1905137 ! regulation of viral DNA genome packaging via site-specific sequence recognition +relationship: positively_regulates GO:0098035 ! viral DNA genome packaging via site-specific sequence recognition + +[Term] +id: GO:1905139 +name: apical ectodermal ridge formation +namespace: biological_process +def: "The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:18359901, PMID:9323126, PMID:9596583] +synonym: "AER formation" RELATED [GOC:TermGenie] +synonym: "apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis +relationship: part_of GO:0035107 ! appendage morphogenesis + +[Term] +id: GO:1905140 +name: regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:1905139 ! apical ectodermal ridge formation + +[Term] +id: GO:1905141 +name: negative regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "down regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "down regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "downregulation of AER formation" RELATED [GOC:TermGenie] +synonym: "downregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "downregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "downregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "inhibition of AER formation" RELATED [GOC:TermGenie] +synonym: "inhibition of apical ectodermal ridge formation" NARROW [GOC:TermGenie] +synonym: "inhibition of apical epidermal ridge formation" NARROW [GOC:TermGenie] +synonym: "inhibition of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905140 ! regulation of apical ectodermal ridge formation +relationship: negatively_regulates GO:1905139 ! apical ectodermal ridge formation + +[Term] +id: GO:1905142 +name: positive regulation of apical ectodermal ridge formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation." [GO_REF:0000058, GOC:TermGenie, PMID:18359901] +synonym: "activation of AER formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "up regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "up regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of AER formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +synonym: "upregulation of AER formation" RELATED [GOC:TermGenie] +synonym: "upregulation of apical ectodermal ridge formation" EXACT [GOC:TermGenie] +synonym: "upregulation of apical epidermal ridge formation" EXACT [GOC:TermGenie] +synonym: "upregulation of crista ectodermalis apicalis formation" RELATED [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905140 ! regulation of apical ectodermal ridge formation +relationship: positively_regulates GO:1905139 ! apical ectodermal ridge formation + +[Term] +id: GO:1905143 +name: eukaryotic translation initiation factor 2 complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2 complex." [GO_REF:0000079, GOC:TermGenie, PMID:23775072] +synonym: "eIF-2 assembly" EXACT [GOC:TermGenie] +synonym: "eIF-2 formation" EXACT [GOC:TermGenie] +synonym: "eIF2 assembly" EXACT [GOC:TermGenie] +synonym: "eIF2 formation" EXACT [GOC:TermGenie] +synonym: "eukaryotic translation initiation factor 2 complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905144 +name: response to acetylcholine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901698 ! response to nitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905145 +name: cellular response to acetylcholine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21238497] +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905144 ! response to acetylcholine + +[Term] +id: GO:1905146 +name: lysosomal protein catabolic process +namespace: biological_process +def: "Any cellular protein catabolic process that takes place in a lysosome." [GO_REF:0000062, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24334770] +comment: Also consider annotating to the term 'autophagy ; GO:0006914' or one of its descendants. +synonym: "cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "cellular protein catabolic process in lysosome" EXACT [] +synonym: "cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "lysosomal protein catabolism" EXACT [GOC:bf] +synonym: "lysosomal protein degradation" EXACT [GOC:bf] +synonym: "lysosomal proteolysis" RELATED [PMID:24334770] +synonym: "proteolysis within lysosome" RELATED [GOC:bf] +is_a: GO:0007039 ! protein catabolic process in the vacuole + +[Term] +id: GO:1905147 +name: regulation of smooth muscle hypertrophy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +is_a: GO:0014743 ! regulation of muscle hypertrophy +is_a: GO:0043502 ! regulation of muscle adaptation +relationship: regulates GO:0014895 ! smooth muscle hypertrophy + +[Term] +id: GO:1905148 +name: negative regulation of smooth muscle hypertrophy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +synonym: "down regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "down-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "downregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "inhibition of smooth muscle hypertrophy" NARROW [GOC:TermGenie] +is_a: GO:0014741 ! negative regulation of muscle hypertrophy +is_a: GO:0014745 ! negative regulation of muscle adaptation +is_a: GO:1905147 ! regulation of smooth muscle hypertrophy +relationship: negatively_regulates GO:0014895 ! smooth muscle hypertrophy + +[Term] +id: GO:1905149 +name: positive regulation of smooth muscle hypertrophy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22161164] +synonym: "activation of smooth muscle hypertrophy" NARROW [GOC:TermGenie] +synonym: "up regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle hypertrophy" EXACT [GOC:TermGenie] +is_a: GO:0014742 ! positive regulation of muscle hypertrophy +is_a: GO:0014744 ! positive regulation of muscle adaptation +is_a: GO:1905147 ! regulation of smooth muscle hypertrophy +relationship: positively_regulates GO:0014895 ! smooth muscle hypertrophy + +[Term] +id: GO:1905150 +name: regulation of voltage-gated sodium channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] +synonym: "regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1905151 +name: negative regulation of voltage-gated sodium channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] +synonym: "down regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "downregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "inhibition of voltage gated sodium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated sodium channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie] +synonym: "inhibition of voltage-sensitive sodium channel" NARROW [GOC:TermGenie] +synonym: "negative regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity +is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1905152 +name: positive regulation of voltage-gated sodium channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of voltage-gated sodium channel activity." [GO_REF:0000059, GOC:TermGenie, PMID:24198377] +synonym: "activation of voltage gated sodium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-dependent sodium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated sodium channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-gated sodium ion channel activity" NARROW [GOC:TermGenie] +synonym: "activation of voltage-sensitive sodium channel" NARROW [GOC:TermGenie] +synonym: "positive regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-dependent sodium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated sodium channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-gated sodium ion channel activity" EXACT [GOC:TermGenie] +synonym: "upregulation of voltage-sensitive sodium channel" EXACT [GOC:TermGenie] +is_a: GO:1905150 ! regulation of voltage-gated sodium channel activity +is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1905153 +name: regulation of membrane invagination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0010324 ! membrane invagination + +[Term] +id: GO:1905154 +name: negative regulation of membrane invagination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] +synonym: "down regulation of membrane invagination" EXACT [GOC:TermGenie] +synonym: "down-regulation of membrane invagination" EXACT [GOC:TermGenie] +synonym: "downregulation of membrane invagination" EXACT [GOC:TermGenie] +synonym: "inhibition of membrane invagination" NARROW [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1905153 ! regulation of membrane invagination +relationship: negatively_regulates GO:0010324 ! membrane invagination + +[Term] +id: GO:1905155 +name: positive regulation of membrane invagination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of membrane invagination." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of membrane invagination" NARROW [GOC:TermGenie] +synonym: "up regulation of membrane invagination" EXACT [GOC:TermGenie] +synonym: "up-regulation of membrane invagination" EXACT [GOC:TermGenie] +synonym: "upregulation of membrane invagination" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905153 ! regulation of membrane invagination +relationship: positively_regulates GO:0010324 ! membrane invagination + +[Term] +id: GO:1905156 +name: negative regulation of photosynthesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] +synonym: "down regulation of photosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of photosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of photosynthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of photosynthesis" NARROW [GOC:TermGenie] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0031324 ! negative regulation of cellular metabolic process +relationship: negatively_regulates GO:0015979 ! photosynthesis + +[Term] +id: GO:1905157 +name: positive regulation of photosynthesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of photosynthesis." [GO_REF:0000058, GOC:TermGenie, PMID:7592491] +synonym: "activation of photosynthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of photosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of photosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of photosynthesis" EXACT [GOC:TermGenie] +is_a: GO:0010109 ! regulation of photosynthesis +is_a: GO:0031325 ! positive regulation of cellular metabolic process +relationship: positively_regulates GO:0015979 ! photosynthesis + +[Term] +id: GO:1905158 +name: obsolete regulation of Factor XII activation +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] +comment: This term was accidentally approved after TermGenie review. It should not have been approved. +synonym: "regulation of Hageman factor activation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905159 +name: obsolete negative regulation of Factor XII activation +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] +comment: This term was accidentally approved after TermGenie review. It should not have been approved. +synonym: "down regulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "down regulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "downregulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "downregulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "inhibition of Factor XII activation" NARROW [GOC:TermGenie] +synonym: "inhibition of Hageman factor activation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Hageman factor activation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905160 +name: obsolete positive regulation of Factor XII activation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of Factor XII activation." [GO_REF:0000058, GOC:TermGenie, PMID:617517] +comment: This term was accidentally approved after TermGenie review. It should not have been approved. +synonym: "activation of Factor XII activation" NARROW [GOC:TermGenie] +synonym: "activation of Hageman factor activation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "up regulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "up regulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Hageman factor activation" EXACT [GOC:TermGenie] +synonym: "upregulation of Factor XII activation" EXACT [GOC:TermGenie] +synonym: "upregulation of Hageman factor activation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905161 +name: protein localization to phagocytic vesicle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a phagocytic vesicle." [GO_REF:0000087, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671] +synonym: "protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "protein localisation to phagosome" EXACT [PMID:23303671] +synonym: "protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "protein recruitment to phagosome" EXACT [PMID:23303671] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:1905162 +name: regulation of phagosome maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:16908865, PMID:23303671] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0090382 ! phagosome maturation + +[Term] +id: GO:1905163 +name: negative regulation of phagosome maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of phagosome maturation" EXACT [GOC:TermGenie] +synonym: "down-regulation of phagosome maturation" EXACT [GOC:TermGenie] +synonym: "downregulation of phagosome maturation" EXACT [GOC:TermGenie] +synonym: "inhibition of phagosome maturation" NARROW [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1905162 ! regulation of phagosome maturation +relationship: negatively_regulates GO:0090382 ! phagosome maturation + +[Term] +id: GO:1905164 +name: positive regulation of phagosome maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phagosome maturation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of phagosome maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of phagosome maturation" EXACT [GOC:TermGenie] +synonym: "up-regulation of phagosome maturation" EXACT [GOC:TermGenie] +synonym: "upregulation of phagosome maturation" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1905162 ! regulation of phagosome maturation +relationship: positively_regulates GO:0090382 ! phagosome maturation + +[Term] +id: GO:1905165 +name: regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23499937] +synonym: "regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904350 ! regulation of protein catabolic process in the vacuole +relationship: regulates GO:1905146 ! lysosomal protein catabolic process + +[Term] +id: GO:1905166 +name: negative regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "down regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "down-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "downregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal protein degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "inhibition of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "negative regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "negative regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904351 ! negative regulation of protein catabolic process in the vacuole +is_a: GO:1905165 ! regulation of lysosomal protein catabolic process +relationship: negatively_regulates GO:1905146 ! lysosomal protein catabolic process + +[Term] +id: GO:1905167 +name: positive regulation of lysosomal protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of cellular protein breakdown in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolic process in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein catabolism in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of cellular protein degradation in lysosome" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein catabolism" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal protein degradation" NARROW [GOC:TermGenie] +synonym: "activation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "activation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "positive regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "positive regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "up regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "up-regulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular protein breakdown in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolic process in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein catabolism in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular protein degradation in lysosome" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal protein degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosomal proteolysis" RELATED [GOC:TermGenie] +synonym: "upregulation of proteolysis within lysosome" RELATED [GOC:TermGenie] +is_a: GO:1904352 ! positive regulation of protein catabolic process in the vacuole +is_a: GO:1905165 ! regulation of lysosomal protein catabolic process +relationship: positively_regulates GO:1905146 ! lysosomal protein catabolic process + +[Term] +id: GO:1905168 +name: positive regulation of double-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination." [GO_REF:0000058, GOC:TermGenie, PMID:12023299] +synonym: "activation of double-strand break repair via homologous recombination" NARROW [GOC:TermGenie] +synonym: "activation of HDR" NARROW [GOC:TermGenie] +synonym: "activation of homologous recombinational repair" NARROW [GOC:TermGenie] +synonym: "activation of homology-directed repair" NARROW [GOC:TermGenie] +synonym: "activation of HRR" NARROW [GOC:TermGenie] +synonym: "activation of Rad51-dependent recombinational repair" NARROW [GOC:TermGenie] +synonym: "activation of Rhp51-dependent recombinational repair" NARROW [GOC:TermGenie] +synonym: "positive regulation of HDR" EXACT [GOC:TermGenie] +synonym: "positive regulation of homologous recombinational repair" EXACT [GOC:TermGenie] +synonym: "positive regulation of homology-directed repair" EXACT [GOC:TermGenie] +synonym: "positive regulation of HRR" EXACT [GOC:TermGenie] +synonym: "positive regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "positive regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "up regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "up regulation of HDR" EXACT [GOC:TermGenie] +synonym: "up regulation of homologous recombinational repair" EXACT [GOC:TermGenie] +synonym: "up regulation of homology-directed repair" EXACT [GOC:TermGenie] +synonym: "up regulation of HRR" EXACT [GOC:TermGenie] +synonym: "up regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "up regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "up-regulation of HDR" EXACT [GOC:TermGenie] +synonym: "up-regulation of homologous recombinational repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of homology-directed repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of HRR" EXACT [GOC:TermGenie] +synonym: "up-regulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "upregulation of double-strand break repair via homologous recombination" EXACT [GOC:TermGenie] +synonym: "upregulation of HDR" EXACT [GOC:TermGenie] +synonym: "upregulation of homologous recombinational repair" EXACT [GOC:TermGenie] +synonym: "upregulation of homology-directed repair" EXACT [GOC:TermGenie] +synonym: "upregulation of HRR" EXACT [GOC:TermGenie] +synonym: "upregulation of Rad51-dependent recombinational repair" EXACT [GOC:TermGenie] +synonym: "upregulation of Rhp51-dependent recombinational repair" EXACT [GOC:TermGenie] +is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination +is_a: GO:0045911 ! positive regulation of DNA recombination +is_a: GO:2000781 ! positive regulation of double-strand break repair +relationship: positively_regulates GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:1905169 +name: regulation of protein localization to phagocytic vesicle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:1905161 ! protein localization to phagocytic vesicle + +[Term] +id: GO:1905170 +name: negative regulation of protein localization to phagocytic vesicle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "downregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to phagosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "inhibition of protein recruitment to phagosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle +relationship: negatively_regulates GO:1905161 ! protein localization to phagocytic vesicle + +[Term] +id: GO:1905171 +name: positive regulation of protein localization to phagocytic vesicle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to phagocytic vesicle." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23303671] +synonym: "activation of protein localisation in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to phagosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to phagocytic vesicle" NARROW [GOC:TermGenie] +synonym: "activation of protein recruitment to phagosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to phagosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to phagocytic vesicle" EXACT [GOC:TermGenie] +synonym: "upregulation of protein recruitment to phagosome" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905169 ! regulation of protein localization to phagocytic vesicle +relationship: positively_regulates GO:1905161 ! protein localization to phagocytic vesicle + +[Term] +id: GO:1905172 +name: RISC complex binding +namespace: molecular_function +def: "Binding to a RISC complex." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24882364] +synonym: "RNA-induced silencing complex binding" EXACT [GOC:TermGenie] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:1905173 +name: eukaryotic translation initiation factor 2B complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an eukaryotic translation initiation factor 2B complex." [GO_REF:0000079, GOC:TermGenie, PMID:27023709] +synonym: "eIF-2B assembly" EXACT [GOC:TermGenie] +synonym: "eIF-2B formation" EXACT [GOC:TermGenie] +synonym: "eif2B assembly" EXACT [GOC:TermGenie] +synonym: "eif2B formation" EXACT [GOC:TermGenie] +synonym: "eukaryotic translation initiation factor 2B complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905174 +name: regulation of vascular associated smooth muscle cell dedifferentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "regulation of vascular smooth muscle cell dedifferentiation" EXACT [] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation + +[Term] +id: GO:1905175 +name: negative regulation of vascular associated smooth muscle cell dedifferentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "down regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell dedifferentiation" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation +relationship: negatively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation + +[Term] +id: GO:1905176 +name: positive regulation of vascular associated smooth muscle cell dedifferentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell dedifferentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19088079] +synonym: "activation of vascular smooth muscle cell dedifferentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell dedifferentiation" EXACT [] +synonym: "up regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell dedifferentiation" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1905174 ! regulation of vascular associated smooth muscle cell dedifferentiation +relationship: positively_regulates GO:1990936 ! vascular associated smooth muscle cell dedifferentiation + +[Term] +id: GO:1905177 +name: tracheary element differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a tracheary element." [GO_REF:0000086, GOC:TermGenie, PMID:20659276] +is_a: GO:0030154 ! cell differentiation + +[Term] +id: GO:1905178 +name: regulation of cardiac muscle tissue regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0061026 ! cardiac muscle tissue regeneration + +[Term] +id: GO:1905179 +name: negative regulation of cardiac muscle tissue regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] +synonym: "down regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration +relationship: negatively_regulates GO:0061026 ! cardiac muscle tissue regeneration + +[Term] +id: GO:1905180 +name: positive regulation of cardiac muscle tissue regeneration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle tissue regeneration." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23222520] +synonym: "activation of cardiac muscle tissue regeneration" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac muscle tissue regeneration" EXACT [GOC:TermGenie] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1905178 ! regulation of cardiac muscle tissue regeneration +relationship: positively_regulates GO:0061026 ! cardiac muscle tissue regeneration + +[Term] +id: GO:1905181 +name: regulation of urease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137] +synonym: "regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] +is_a: GO:0051336 ! regulation of hydrolase activity + +[Term] +id: GO:1905182 +name: positive regulation of urease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of urease activity." [GO_REF:0000059, GOC:TermGenie, PMID:16244137] +synonym: "activation of urea amidohydrolase activity" NARROW [GOC:TermGenie] +synonym: "activation of urease activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of urease activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of urease activity" EXACT [GOC:TermGenie] +synonym: "upregulation of urea amidohydrolase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of urease activity" EXACT [GOC:TermGenie] +is_a: GO:0051345 ! positive regulation of hydrolase activity +is_a: GO:1905181 ! regulation of urease activity + +[Term] +id: GO:1905183 +name: negative regulation of protein serine/threonine phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131] +synonym: "down regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0032515 ! negative regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:1905184 +name: positive regulation of protein serine/threonine phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein serine/threonine phosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:16950131] +synonym: "activation of protein serine/threonine phosphatase activity" NARROW [GOC:TermGenie] +synonym: "activation of serine/threonine specific protein phosphatase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of protein serine/threonine phosphatase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of serine/threonine specific protein phosphatase activity" EXACT [GOC:TermGenie] +is_a: GO:0032516 ! positive regulation of phosphoprotein phosphatase activity + +[Term] +id: GO:1905186 +name: regulation of metaphase/anaphase transition of meiosis I +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +synonym: "regulation of first meiotic metaphase/anaphase transition" RELATED [GOC:TermGenie] +synonym: "regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle +relationship: regulates GO:1990949 ! metaphase/anaphase transition of meiosis I + +[Term] +id: GO:1905187 +name: negative regulation of metaphase/anaphase transition of meiosis I +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I +relationship: negatively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I + +[Term] +id: GO:1905188 +name: positive regulation of metaphase/anaphase transition of meiosis I +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +synonym: "positive regulation of meiosis I metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905186 ! regulation of metaphase/anaphase transition of meiosis I +relationship: positively_regulates GO:1990949 ! metaphase/anaphase transition of meiosis I + +[Term] +id: GO:1905189 +name: regulation of metaphase/anaphase transition of meiosis II +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +synonym: "regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle +relationship: regulates GO:1990950 ! metaphase/anaphase transition of meiosis II + +[Term] +id: GO:1905190 +name: negative regulation of metaphase/anaphase transition of meiosis II +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +synonym: "negative regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1902103 ! negative regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II +relationship: negatively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II + +[Term] +id: GO:1905191 +name: positive regulation of metaphase/anaphase transition of meiosis II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II." [GO_REF:0000058, GOC:TermGenie, PMID:21389117] +synonym: "positive regulation of meiosis II metaphase/anaphase transition" EXACT [GOC:TermGenie] +is_a: GO:1902104 ! positive regulation of metaphase/anaphase transition of meiotic cell cycle +is_a: GO:1905189 ! regulation of metaphase/anaphase transition of meiosis II +relationship: positively_regulates GO:1990950 ! metaphase/anaphase transition of meiosis II + +[Term] +id: GO:1905192 +name: regulation of chloroplast fission +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] +comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. +synonym: "regulation of chloroplast division" EXACT [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +relationship: regulates GO:0010020 ! chloroplast fission + +[Term] +id: GO:1905193 +name: negative regulation of chloroplast fission +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] +comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. +synonym: "down regulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "down regulation of chloroplast fission" EXACT [GOC:TermGenie] +synonym: "down-regulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "down-regulation of chloroplast fission" EXACT [GOC:TermGenie] +synonym: "downregulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "downregulation of chloroplast fission" EXACT [GOC:TermGenie] +synonym: "inhibition of chloroplast division" NARROW [GOC:TermGenie] +synonym: "inhibition of chloroplast fission" NARROW [GOC:TermGenie] +synonym: "negative regulation of chloroplast division" EXACT [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1905192 ! regulation of chloroplast fission +relationship: negatively_regulates GO:0010020 ! chloroplast fission + +[Term] +id: GO:1905194 +name: positive regulation of chloroplast fission +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chloroplast fission." [GO_REF:0000058, GOC:TermGenie, PMID:26862170] +comment: Any process that modulates the rate, frequency or extent of chloroplast fission. Chloroplast fission is the division of a chloroplast within a cell to form two or more separate chloroplast compartments. +synonym: "activation of chloroplast division" NARROW [GOC:TermGenie] +synonym: "activation of chloroplast fission" NARROW [GOC:TermGenie] +synonym: "positive regulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "up regulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "up regulation of chloroplast fission" EXACT [GOC:TermGenie] +synonym: "up-regulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "up-regulation of chloroplast fission" EXACT [GOC:TermGenie] +synonym: "upregulation of chloroplast division" EXACT [GOC:TermGenie] +synonym: "upregulation of chloroplast fission" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1905192 ! regulation of chloroplast fission +relationship: positively_regulates GO:0010020 ! chloroplast fission + +[Term] +id: GO:1905195 +name: obsolete regulation of ATPase activity, uncoupled +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917] +comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. +synonym: "regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905196 +name: obsolete positive regulation of ATPase activity, uncoupled +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATPase activity, uncoupled." [GO_REF:0000059, GOC:TermGenie, PMID:26545917] +comment: The reason for obsoletion is that the there is no convincing example of a protein with this function. +synonym: "activation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +synonym: "activation of ATPase activity, uncoupled" NARROW [GOC:TermGenie] +synonym: "positive regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +synonym: "up regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] +synonym: "up-regulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +synonym: "up-regulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] +synonym: "upregulation of adenylpyrophosphatase activity" RELATED [GOC:TermGenie] +synonym: "upregulation of ATPase activity, uncoupled" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905197 +name: endocannabinoid signaling pathway involved in retrograde trans-synaptic signaling +namespace: biological_process +def: "Any endocannabinoid signaling pathway that is involved in retrograde trans-synaptic signaling by endocannabinoid." [GO_REF:0000060, GOC:TermGenie, PMID:23040807] +synonym: "endocannabinoid signalling pathway involved in retrograde trans-synaptic signaling by endocannabinoid" EXACT [GOC:TermGenie] +is_a: GO:1905129 ! endocannabinoid signaling pathway involved in trans-synaptic signaling +relationship: part_of GO:0098921 ! retrograde trans-synaptic signaling by endocannabinoid + +[Term] +id: GO:1905198 +name: manchette assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a manchette." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866] +synonym: "manchette formation" EXACT [GOC:TermGenie] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:1905199 +name: manchette disassembly +namespace: biological_process +def: "The disaggregation of a manchette into its constituent components." [GO_REF:0000079, GOC:krc, GOC:TermGenie, PMID:22319670, PMID:24440897, PMID:26792866] +is_a: GO:0022411 ! cellular component disassembly +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:1905200 +name: gibberellic acid transmembrane transport +namespace: biological_process +def: "The directed movement of gibberellic acid across a membrane." [GO_REF:0000069, GOC:TermGenie, PMID:27139299] +is_a: GO:0046865 ! terpenoid transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport + +[Term] +id: GO:1905201 +name: gibberellin transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of gibberellin from one side of a membrane to the other." [GO_REF:0000070, GOC:TermGenie, PMID:27139299] +is_a: GO:0005319 ! lipid transporter activity +is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity + +[Term] +id: GO:1905202 +name: methylcrotonoyl-CoA carboxylase complex +namespace: cellular_component +def: "A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity." [GO_REF:0000088, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22158123] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905203 +name: regulation of connective tissue replacement +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] +is_a: GO:0034103 ! regulation of tissue remodeling +relationship: regulates GO:0097709 ! connective tissue replacement + +[Term] +id: GO:1905204 +name: negative regulation of connective tissue replacement +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] +synonym: "down regulation of connective tissue replacement" EXACT [GOC:TermGenie] +synonym: "down-regulation of connective tissue replacement" EXACT [GOC:TermGenie] +synonym: "downregulation of connective tissue replacement" EXACT [GOC:TermGenie] +synonym: "inhibition of connective tissue replacement" NARROW [GOC:TermGenie] +is_a: GO:0034104 ! negative regulation of tissue remodeling +is_a: GO:1905203 ! regulation of connective tissue replacement +relationship: negatively_regulates GO:0097709 ! connective tissue replacement + +[Term] +id: GO:1905205 +name: positive regulation of connective tissue replacement +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of connective tissue replacement." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961] +synonym: "activation of connective tissue replacement" NARROW [GOC:TermGenie] +synonym: "up regulation of connective tissue replacement" EXACT [GOC:TermGenie] +synonym: "up-regulation of connective tissue replacement" EXACT [GOC:TermGenie] +synonym: "upregulation of connective tissue replacement" EXACT [GOC:TermGenie] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:1905203 ! regulation of connective tissue replacement +relationship: positively_regulates GO:0097709 ! connective tissue replacement + +[Term] +id: GO:1905206 +name: positive regulation of hydrogen peroxide-induced cell death +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:20550618] +synonym: "activation of cell death in response to H2O2" NARROW [GOC:TermGenie] +synonym: "activation of cell death in response to hydrogen peroxide" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "positive regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "positive regulation of cell death in response to hydrogen peroxide" EXACT [] +synonym: "positive regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "up regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "up regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "up-regulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +synonym: "upregulation of cell death in response to H2O2" EXACT [GOC:TermGenie] +synonym: "upregulation of cell death in response to hydrogen peroxide" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen peroxide-mediated cell death" RELATED [GOC:TermGenie] +is_a: GO:1901033 ! positive regulation of response to reactive oxygen species +is_a: GO:1903205 ! regulation of hydrogen peroxide-induced cell death +is_a: GO:1903209 ! positive regulation of oxidative stress-induced cell death +relationship: positively_regulates GO:0036474 ! cell death in response to hydrogen peroxide + +[Term] +id: GO:1905207 +name: regulation of cardiocyte differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of heart cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:1905208 +name: negative regulation of cardiocyte differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "down regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of cardiocyte differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of heart cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of heart cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: negatively_regulates GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:1905209 +name: positive regulation of cardiocyte differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "activation of cardiac cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of cardiocyte differentiation" NARROW [GOC:TermGenie] +synonym: "activation of heart cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiocyte differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of heart cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: positively_regulates GO:0035051 ! cardiocyte differentiation + +[Term] +id: GO:1905210 +name: regulation of fibroblast chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:1990956 ! fibroblast chemotaxis + +[Term] +id: GO:1905211 +name: negative regulation of fibroblast chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] +synonym: "down regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +synonym: "down-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +synonym: "downregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +synonym: "inhibition of fibroblast chemotaxis" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:1905210 ! regulation of fibroblast chemotaxis +relationship: negatively_regulates GO:1990956 ! fibroblast chemotaxis + +[Term] +id: GO:1905212 +name: positive regulation of fibroblast chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast chemotaxis." [GO_REF:0000058, GOC:TermGenie, PMID:8760137] +synonym: "activation of fibroblast chemotaxis" NARROW [GOC:TermGenie] +synonym: "up regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +synonym: "up-regulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +synonym: "upregulation of fibroblast chemotaxis" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1905210 ! regulation of fibroblast chemotaxis +relationship: positively_regulates GO:1990956 ! fibroblast chemotaxis + +[Term] +id: GO:1905213 +name: negative regulation of mitotic chromosome condensation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation." [GO_REF:0000058, GOC:TermGenie, PMID:23219725] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:1902340 ! negative regulation of chromosome condensation +is_a: GO:1903379 ! regulation of mitotic chromosome condensation +relationship: negatively_regulates GO:0007076 ! mitotic chromosome condensation + +[Term] +id: GO:1905214 +name: regulation of RNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1905215 +name: negative regulation of RNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of RNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA binding" NARROW [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1905214 ! regulation of RNA binding + +[Term] +id: GO:1905216 +name: positive regulation of RNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA binding." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] +synonym: "activation of RNA binding" NARROW [GOC:TermGenie] +synonym: "up regulation of RNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1905214 ! regulation of RNA binding + +[Term] +id: GO:1905217 +name: response to astaxanthin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] +synonym: "response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1905218 +name: cellular response to astaxanthin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an astaxanthin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22309505] +synonym: "cellular response to (3S,3'S)-3,3'-dihydroxy-beta,beta-carotene-4,4'-dione" EXACT [] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1905217 ! response to astaxanthin + +[Term] +id: GO:1905219 +name: regulation of platelet formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] +synonym: "regulation of platelet extrusion" EXACT [GOC:TermGenie] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0045637 ! regulation of myeloid cell differentiation +relationship: regulates GO:0030220 ! platelet formation + +[Term] +id: GO:1905220 +name: negative regulation of platelet formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] +synonym: "down regulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "down regulation of platelet formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of platelet formation" EXACT [GOC:TermGenie] +synonym: "downregulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "downregulation of platelet formation" EXACT [GOC:TermGenie] +synonym: "inhibition of platelet extrusion" NARROW [GOC:TermGenie] +synonym: "inhibition of platelet formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of platelet extrusion" EXACT [GOC:TermGenie] +is_a: GO:0045638 ! negative regulation of myeloid cell differentiation +is_a: GO:1905219 ! regulation of platelet formation +relationship: negatively_regulates GO:0030220 ! platelet formation + +[Term] +id: GO:1905221 +name: positive regulation of platelet formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] +synonym: "activation of platelet extrusion" NARROW [GOC:TermGenie] +synonym: "activation of platelet formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "up regulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "up regulation of platelet formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of platelet formation" EXACT [GOC:TermGenie] +synonym: "upregulation of platelet extrusion" EXACT [GOC:TermGenie] +synonym: "upregulation of platelet formation" EXACT [GOC:TermGenie] +is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0045639 ! positive regulation of myeloid cell differentiation +is_a: GO:1905219 ! regulation of platelet formation +relationship: positively_regulates GO:0030220 ! platelet formation + +[Term] +id: GO:1905222 +name: atrioventricular canal morphogenesis +namespace: biological_process +def: "The developmental process by which an atrioventricular canal is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19703439] +synonym: "atrial canal morphogenesis" EXACT [GOC:TermGenie] +synonym: "atrio-ventricular canal morphogenesis" EXACT [GOC:TermGenie] +synonym: "AV canal morphogenesis" EXACT [GOC:TermGenie] +synonym: "AVC morphogenesis" EXACT [GOC:TermGenie] +synonym: "canalis atrioventricularis morphogenesis" RELATED [GOC:TermGenie] +synonym: "ependymal canal morphogenesis" RELATED [GOC:TermGenie] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0036302 ! atrioventricular canal development + +[Term] +id: GO:1905223 +name: epicardium morphogenesis +namespace: biological_process +def: "The developmental process by which an epicardium is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18718461] +synonym: "heart epicardium morphogenesis" EXACT [GOC:TermGenie] +synonym: "pericardium visceral mesothelium morphogenesis" RELATED [GOC:TermGenie] +synonym: "visceral serous pericardium of heart morphogenesis" EXACT [GOC:TermGenie] +synonym: "visceral serous pericardium proper morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:1905224 +name: clathrin-coated pit assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] +synonym: "clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "coated pit assembly" EXACT [GOC:TermGenie] +synonym: "coated pit formation" EXACT [GOC:TermGenie] +is_a: GO:0071709 ! membrane assembly + +[Term] +id: GO:1905225 +name: response to thyrotropin-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:sl, GOC:TermGenie, PMID:21382270] +synonym: "response to protirelin" EXACT [] +synonym: "response to TRH" RELATED [] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1905226 +name: regulation of adhesion of symbiont to host epithelial cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] +is_a: GO:0043903 ! regulation of biological process involved in symbiotic interaction +relationship: regulates GO:0044651 ! adhesion of symbiont to host epithelial cell + +[Term] +id: GO:1905227 +name: negative regulation of adhesion of symbiont to host epithelial cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] +synonym: "down regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +synonym: "downregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +synonym: "inhibition of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1905226 ! regulation of adhesion of symbiont to host epithelial cell +relationship: negatively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell + +[Term] +id: GO:1905228 +name: positive regulation of adhesion of symbiont to host epithelial cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adhesion of symbiont to host epithelial cell." [GO_REF:0000058, GOC:TermGenie, PMID:15659068] +synonym: "activation of adhesion of symbiont to host epithelial cell" NARROW [GOC:TermGenie] +synonym: "up regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +synonym: "upregulation of adhesion of symbiont to host epithelial cell" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1905226 ! regulation of adhesion of symbiont to host epithelial cell +relationship: positively_regulates GO:0044651 ! adhesion of symbiont to host epithelial cell + +[Term] +id: GO:1905229 +name: cellular response to thyrotropin-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] +synonym: "cellular response to protirelin" EXACT [] +synonym: "cellular response to TRH" RELATED [] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1905225 ! response to thyrotropin-releasing hormone + +[Term] +id: GO:1905230 +name: response to borneol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1905231 +name: cellular response to borneol +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a borneol stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26593909] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1905230 ! response to borneol + +[Term] +id: GO:1905232 +name: cellular response to L-glutamate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25962137] +synonym: "cellular response to L-glutamate(1-)" RELATED [] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1902065 ! response to L-glutamate + +[Term] +id: GO:1905233 +name: response to codeine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +is_a: GO:0014072 ! response to isoquinoline alkaloid + +[Term] +id: GO:1905234 +name: cellular response to codeine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a codeine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +is_a: GO:0071317 ! cellular response to isoquinoline alkaloid +is_a: GO:1905233 ! response to codeine + +[Term] +id: GO:1905235 +name: response to quercetin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +is_a: GO:1905395 ! response to flavonoid + +[Term] +id: GO:1905236 +name: cellular response to quercetin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quercetin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +is_a: GO:1905235 ! response to quercetin +is_a: GO:1905396 ! cellular response to flavonoid + +[Term] +id: GO:1905237 +name: response to cyclosporin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +synonym: "response to cyclophilin" EXACT [] +is_a: GO:1901652 ! response to peptide + +[Term] +id: GO:1905238 +name: cellular response to cyclosporin A +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclosporin A stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:24914722] +synonym: "cellular response to cyclophilin" EXACT [] +is_a: GO:1901653 ! cellular response to peptide +is_a: GO:1905237 ! response to cyclosporin A + +[Term] +id: GO:1905239 +name: regulation of canonical Wnt signaling pathway involved in osteoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation + +[Term] +id: GO:1905240 +name: negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] +synonym: "down regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +is_a: GO:1905239 ! regulation of canonical Wnt signaling pathway involved in osteoblast differentiation +relationship: negatively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation + +[Term] +id: GO:1905241 +name: positive regulation of canonical Wnt signaling pathway involved in osteoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in osteoblast differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:19342382] +synonym: "activation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "activation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt receptor signalling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of canonical Wnt-activated signaling pathway involved in osteoblast differentiation" EXACT [GOC:TermGenie] +is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway +is_a: GO:1905239 ! regulation of canonical Wnt signaling pathway involved in osteoblast differentiation +relationship: positively_regulates GO:0044339 ! canonical Wnt signaling pathway involved in osteoblast differentiation + +[Term] +id: GO:1905242 +name: response to 3,3',5-triiodo-L-thyronine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] +synonym: "response to Liothyronin" EXACT [] +synonym: "response to Liothyronine" EXACT [] +synonym: "response to Liothyroninum" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1905243 +name: cellular response to 3,3',5-triiodo-L-thyronine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 3,3',5-triiodo-L-thyronine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:21382270] +synonym: "cellular response to Liothyronin" EXACT [] +synonym: "cellular response to Liothyronine" EXACT [] +synonym: "cellular response to Liothyroninum" EXACT [] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1905242 ! response to 3,3',5-triiodo-L-thyronine + +[Term] +id: GO:1905244 +name: regulation of modification of synaptic structure +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of modification of synaptic structure." [GO_REF:0000058, GOC:TermGenie, PMID:25164660] +subset: goslim_synapse +synonym: "regulation of synapse remodelling" EXACT [GOC:TermGenie] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0099563 ! modification of synaptic structure + +[Term] +id: GO:1905245 +name: regulation of aspartic-type peptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:1905246 +name: negative regulation of aspartic-type peptidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] +synonym: "down regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of aspartic-type peptidase activity" NARROW [GOC:TermGenie] +synonym: "pepsin inhibitor" RELATED [] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:1905245 ! regulation of aspartic-type peptidase activity + +[Term] +id: GO:1905247 +name: positive regulation of aspartic-type peptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aspartic-type peptidase activity." [GO_REF:0000059, GOC:jl, GOC:TermGenie, PMID:21745575] +synonym: "activation of aspartic-type peptidase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of aspartic-type peptidase activity" EXACT [GOC:TermGenie] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:1905245 ! regulation of aspartic-type peptidase activity + +[Term] +id: GO:1905248 +name: obsolete regulation of memory +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "modulation of memory" NARROW [] +is_obsolete: true + +[Term] +id: GO:1905249 +name: obsolete negative regulation of memory +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "inhibition of memory" NARROW [GOC:TermGenie] +synonym: "suppression of memory" EXACT [] +is_obsolete: true + +[Term] +id: GO:1905250 +name: obsolete positive regulation of memory +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of memory." [GO_REF:0000058, GOC:TermGenie, PMID:25905804] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "enhancement of memory" NARROW [] +is_obsolete: true + +[Term] +id: GO:1905251 +name: epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway +relationship: part_of GO:0003015 ! heart process + +[Term] +id: GO:1905252 +name: obsolete regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905253 +name: obsolete negative regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any negative regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905254 +name: obsolete positive regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "OBSOLETE. Any positive regulation of epidermal growth factor receptor signaling pathway that is involved in heart process." [GO_REF:0000060, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "stimulation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905255 +name: regulation of RNA binding transcription factor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] +synonym: "regulation of transcription factor activity" BROAD [GOC:TermGenie] +is_a: GO:0065009 ! regulation of molecular function + +[Term] +id: GO:1905256 +name: negative regulation of RNA binding transcription factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +synonym: "inhibition of RNA binding transcription factor activity" NARROW [GOC:TermGenie] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:1905255 ! regulation of RNA binding transcription factor activity + +[Term] +id: GO:1905257 +name: positive regulation of RNA binding transcription factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA binding transcription factor activity." [GO_REF:0000059, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:25116364] +synonym: "activation of RNA binding transcription factor activity" NARROW [GOC:TermGenie] +synonym: "up regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA binding transcription factor activity" EXACT [GOC:TermGenie] +is_a: GO:0044093 ! positive regulation of molecular function +is_a: GO:1905255 ! regulation of RNA binding transcription factor activity + +[Term] +id: GO:1905258 +name: regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510] +synonym: "regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] +synonym: "regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +is_a: GO:0080135 ! regulation of cellular response to stress +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress + +[Term] +id: GO:1905259 +name: negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:14752510] +synonym: "down regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "down regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "down regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "down-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "down-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "downregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "downregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie] +synonym: "inhibition of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "inhibition of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] +synonym: "negative regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:2001243 ! negative regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress + +[Term] +id: GO:1905260 +name: positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to nitrosative stress." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of intrinsic apoptotic signaling pathway in response to nitrosative stress" NARROW [GOC:TermGenie] +synonym: "activation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "activation of nitrosative stress-induced intrinsic apoptotic signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:bf] +synonym: "positive regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "up regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "up regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "up-regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of intrinsic apoptotic signaling pathway in response to nitrosative stress" EXACT [GOC:TermGenie] +synonym: "upregulation of nitrosative stress-induced apoptosis" RELATED [GOC:TermGenie] +synonym: "upregulation of nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1905258 ! regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway +is_a: GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:1990442 ! intrinsic apoptotic signaling pathway in response to nitrosative stress + +[Term] +id: GO:1905261 +name: regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] +is_a: GO:0022414 ! reproductive process +is_a: GO:1903341 ! regulation of meiotic DNA double-strand break formation +relationship: part_of GO:0007131 ! reciprocal meiotic recombination +relationship: regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + +[Term] +id: GO:1905262 +name: negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] +synonym: "down regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +synonym: "down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +synonym: "downregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +synonym: "inhibition of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie] +is_a: GO:1903342 ! negative regulation of meiotic DNA double-strand break formation +is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +relationship: negatively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + +[Term] +id: GO:1905263 +name: positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination." [GO_REF:0000058, GOC:TermGenie, PMID:26653857] +synonym: "activation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" NARROW [GOC:TermGenie] +synonym: "up regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +synonym: "upregulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination" EXACT [GOC:TermGenie] +is_a: GO:1903343 ! positive regulation of meiotic DNA double-strand break formation +is_a: GO:1905261 ! regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination +relationship: positively_regulates GO:0010780 ! meiotic DNA double-strand break formation involved in reciprocal meiotic recombination + +[Term] +id: GO:1905264 +name: blasticidin S metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S] +synonym: "blasticidin S metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006213 ! pyrimidine nucleoside metabolic process + +[Term] +id: GO:1905265 +name: blasticidin S catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S] +synonym: "blasticidin S breakdown" EXACT [GOC:TermGenie] +synonym: "blasticidin S catabolism" EXACT [GOC:TermGenie] +synonym: "blasticidin S degradation" EXACT [GOC:TermGenie] +is_a: GO:0046135 ! pyrimidine nucleoside catabolic process +is_a: GO:1905264 ! blasticidin S metabolic process + +[Term] +id: GO:1905266 +name: blasticidin S biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of blasticidin S." [GO_REF:0000068, GOC:pr, GOC:TermGenie, PMID:23874663, Wikipedia:Blasticidin_S] +synonym: "blasticidin S anabolism" EXACT [GOC:TermGenie] +synonym: "blasticidin S biosynthesis" EXACT [GOC:TermGenie] +synonym: "blasticidin S formation" EXACT [GOC:TermGenie] +synonym: "blasticidin S synthesis" EXACT [GOC:TermGenie] +is_a: GO:0046134 ! pyrimidine nucleoside biosynthetic process +is_a: GO:1905264 ! blasticidin S metabolic process + +[Term] +id: GO:1905267 +name: endonucleolytic cleavage involved in tRNA processing +namespace: biological_process +def: "Any endonucleolytic RNA phosphodiester bond hydrolysis that is involved in tRNA processing." [GO_REF:0000060, GOC:TermGenie, PMID:25401760] +synonym: "RNA phosphodiester bond hydrolysis, endonucleolytic involved in tRNA maturation" EXACT [GOC:TermGenie] +is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic +relationship: part_of GO:0008033 ! tRNA processing + +[Term] +id: GO:1905268 +name: negative regulation of chromatin organization +namespace: biological_process +alt_id: GO:1903309 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] +synonym: "down regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "down regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "downregulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "downregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "inhibition of chromatin organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of chromatin organization" NARROW [GOC:TermGenie] +synonym: "inhibition of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] +synonym: "negative regulation of chromatin modification" RELATED [] +synonym: "negative regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1902275 ! regulation of chromatin organization +relationship: negatively_regulates GO:0006325 ! chromatin organization + +[Term] +id: GO:1905269 +name: positive regulation of chromatin organization +namespace: biological_process +alt_id: GO:1903310 +def: "Any process that activates or increases the frequency, rate or extent of chromatin organization." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:vw, PMID:654321] +synonym: "activation of chromatin organisation" NARROW [GOC:TermGenie] +synonym: "activation of chromatin organization" NARROW [GOC:TermGenie] +synonym: "activation of establishment or maintenance of chromatin architecture" NARROW [GOC:TermGenie] +synonym: "positive regulation of chromatin modification" RELATED [] +synonym: "positive regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "up regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "up regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +synonym: "upregulation of chromatin organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of chromatin organization" EXACT [GOC:TermGenie] +synonym: "upregulation of establishment or maintenance of chromatin architecture" EXACT [GOC:TermGenie] +is_a: GO:1902275 ! regulation of chromatin organization +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0006325 ! chromatin organization + +[Term] +id: GO:1905270 +name: Meynert cell differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a Meynert cell." [GO_REF:0000086, GOC:TermGenie, PMID:4142639] +is_a: GO:0021859 ! pyramidal neuron differentiation + +[Term] +id: GO:1905271 +name: regulation of proton-transporting ATP synthase activity, rotational mechanism +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] +synonym: "regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0051340 ! regulation of ligase activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:1905272 +name: negative regulation of proton-transporting ATP synthase activity, rotational mechanism +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] +synonym: "down regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "down regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "down-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "down-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "downregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "downregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "inhibition of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] +synonym: "inhibition of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] +synonym: "negative regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "negative regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +is_a: GO:0051352 ! negative regulation of ligase activity +is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism +is_a: GO:2001258 ! negative regulation of cation channel activity + +[Term] +id: GO:1905273 +name: positive regulation of proton-transporting ATP synthase activity, rotational mechanism +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." [GO_REF:0000059, GOC:als, GOC:TermGenie, PMID:21106936] +synonym: "activation of H+-transporting ATP synthase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen ion translocating F-type ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen ion transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] +synonym: "activation of hydrogen ion transporting two-sector ATPase activity" NARROW [GOC:TermGenie] +synonym: "activation of proton-transporting ATP synthase activity, rotational mechanism" NARROW [GOC:TermGenie] +synonym: "positive regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "positive regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "up regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "up-regulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "up-regulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "upregulation of H+-transporting ATP synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen ion translocating F-type ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +synonym: "upregulation of hydrogen ion transporting two-sector ATPase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of proton-transporting ATP synthase activity, rotational mechanism" EXACT [GOC:TermGenie] +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:1905271 ! regulation of proton-transporting ATP synthase activity, rotational mechanism +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:1905274 +name: regulation of modification of postsynaptic actin cytoskeleton +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton." [GO_REF:0000058, GOC:TermGenie, PMID:21068295] +subset: goslim_synapse +synonym: "regulation of postsynaptic actin cytoskeleton remodelling" EXACT [GOC:TermGenie] +is_a: GO:0099159 ! regulation of modification of postsynaptic structure +relationship: regulates GO:0098885 ! modification of postsynaptic actin cytoskeleton + +[Term] +id: GO:1905275 +name: Rohon-Beard neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a Rohon-Beard neuron." [GO_REF:0000086, GOC:TermGenie, ZFIN:ZDB-PUB-120807-45] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:1905276 +name: regulation of epithelial tube formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0072175 ! epithelial tube formation + +[Term] +id: GO:1905277 +name: negative regulation of epithelial tube formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +synonym: "down regulation of epithelial tube formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelial tube formation" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelial tube formation" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelial tube formation" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905276 ! regulation of epithelial tube formation +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0072175 ! epithelial tube formation + +[Term] +id: GO:1905278 +name: positive regulation of epithelial tube formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial tube formation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +synonym: "activation of epithelial tube formation" NARROW [GOC:TermGenie] +synonym: "up regulation of epithelial tube formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelial tube formation" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelial tube formation" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905276 ! regulation of epithelial tube formation +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0072175 ! epithelial tube formation + +[Term] +id: GO:1905279 +name: regulation of retrograde transport, endosome to Golgi +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:23395371] +synonym: "regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: regulates GO:0042147 ! retrograde transport, endosome to Golgi + +[Term] +id: GO:1905280 +name: negative regulation of retrograde transport, endosome to Golgi +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "down regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +synonym: "inhibition of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie] +synonym: "inhibition of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie] +synonym: "negative regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +is_a: GO:1903650 ! negative regulation of cytoplasmic transport +is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi +relationship: negatively_regulates GO:0042147 ! retrograde transport, endosome to Golgi + +[Term] +id: GO:1905281 +name: positive regulation of retrograde transport, endosome to Golgi +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde transport, endosome to Golgi." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of retrograde (endosome to Golgi) transport" NARROW [GOC:TermGenie] +synonym: "activation of retrograde transport, endosome to Golgi" NARROW [GOC:TermGenie] +synonym: "positive regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "up regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "up regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde (endosome to Golgi) transport" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde transport, endosome to Golgi" EXACT [GOC:TermGenie] +is_a: GO:1903651 ! positive regulation of cytoplasmic transport +is_a: GO:1905279 ! regulation of retrograde transport, endosome to Golgi +relationship: positively_regulates GO:0042147 ! retrograde transport, endosome to Golgi + +[Term] +id: GO:1905282 +name: regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway +relationship: regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process + +[Term] +id: GO:1905283 +name: negative regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "down regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "inhibition of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process +relationship: negatively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process + +[Term] +id: GO:1905284 +name: positive regulation of epidermal growth factor receptor signaling pathway involved in heart process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process." [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:23069713] +synonym: "activation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of EGF receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of EGF receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of EGFR signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of epidermal growth factor receptor signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of epidermal growth factor receptor signalling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of ERBB1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" NARROW [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of EGF receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of EGF receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of EGF receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of EGF receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of EGFR signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of EGFR signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of epidermal growth factor receptor signalling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of ERBB1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of ERBB1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process" EXACT [GOC:TermGenie] +is_a: GO:0045742 ! positive regulation of epidermal growth factor receptor signaling pathway +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905282 ! regulation of epidermal growth factor receptor signaling pathway involved in heart process +relationship: positively_regulates GO:1905251 ! epidermal growth factor receptor signaling pathway involved in heart process + +[Term] +id: GO:1905285 +name: fibrous ring of heart morphogenesis +namespace: biological_process +def: "The developmental process by which a fibrous ring of heart is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16037571] +synonym: "annulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] +synonym: "anulus fibrosus cordis morphogenesis" RELATED [GOC:TermGenie] +synonym: "anulus fibrosus of heart morphogenesis" EXACT [GOC:TermGenie] +synonym: "aortic annulus morphogenesis" RELATED [GOC:TermGenie] +synonym: "atrioventricular ring morphogenesis" RELATED [GOC:TermGenie] +synonym: "coronary tendon morphogenesis" RELATED [GOC:TermGenie] +synonym: "Lower's ring morphogenesis" RELATED [GOC:TermGenie] +is_a: GO:0048729 ! tissue morphogenesis + +[Term] +id: GO:1905286 +name: serine-type peptidase complex +namespace: cellular_component +def: "A protein complex which is capable of serine-type peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965] +comment: An example of this is F7 in human (P08709) in PMID:18640965 (inferred from direct assay). +synonym: "Factor VII - TF complex" NARROW [] +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:1905287 +name: positive regulation of G2/M transition of mitotic cell cycle involved in cellular response to nitrogen starvation +namespace: biological_process +def: "Any positive regulation of G2/M transition of mitotic cell cycle that is involved in cellular response to nitrogen starvation." [GO_REF:0000060, GOC:TermGenie, PMID:26776736] +synonym: "positive regulation of mitotic entry involved in cellular response to nitrogen starvation" EXACT [GOC:TermGenie] +is_a: GO:0010971 ! positive regulation of G2/M transition of mitotic cell cycle +relationship: part_of GO:0006995 ! cellular response to nitrogen starvation + +[Term] +id: GO:1905288 +name: vascular associated smooth muscle cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a vascular associated smooth muscle cell." [GO_REF:0000085, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] +synonym: "vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "VSMC apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0034390 ! smooth muscle cell apoptotic process + +[Term] +id: GO:1905289 +name: regulation of CAMKK-AMPK signaling cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] +synonym: "regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +is_a: GO:0050848 ! regulation of calcium-mediated signaling +relationship: regulates GO:0061762 ! CAMKK-AMPK signaling cascade + +[Term] +id: GO:1905290 +name: negative regulation of CAMKK-AMPK signaling cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] +synonym: "down regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "down regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "down-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "down-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "downregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "downregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "inhibition of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie] +synonym: "inhibition of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "negative regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +is_a: GO:0050849 ! negative regulation of calcium-mediated signaling +is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade +relationship: negatively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade + +[Term] +id: GO:1905291 +name: positive regulation of CAMKK-AMPK signaling cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade." [GO_REF:0000058, GOC:TermGenie, PMID:22128786] +synonym: "activation of CAMKK-AMPK signaling cascade" NARROW [GOC:TermGenie] +synonym: "activation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "positive regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "up regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "up regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "up-regulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "up-regulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +synonym: "upregulation of CAMKK-AMPK signaling cascade" EXACT [GOC:TermGenie] +synonym: "upregulation of stress-activated AMP-activated protein kinase signaling cascade" RELATED [GOC:TermGenie] +is_a: GO:0050850 ! positive regulation of calcium-mediated signaling +is_a: GO:1905289 ! regulation of CAMKK-AMPK signaling cascade +relationship: positively_regulates GO:0061762 ! CAMKK-AMPK signaling cascade + +[Term] +id: GO:1905292 +name: regulation of neural crest cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: regulates GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:1905293 +name: negative regulation of neural crest cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +synonym: "down regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of neural crest cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905292 ! regulation of neural crest cell differentiation +is_a: GO:2000737 ! negative regulation of stem cell differentiation +relationship: negatively_regulates GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:1905294 +name: positive regulation of neural crest cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +synonym: "activation of neural crest cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of neural crest cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905292 ! regulation of neural crest cell differentiation +is_a: GO:2000738 ! positive regulation of stem cell differentiation +relationship: positively_regulates GO:0014033 ! neural crest cell differentiation + +[Term] +id: GO:1905295 +name: regulation of neural crest cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:0090299 ! regulation of neural crest formation +is_a: GO:1905292 ! regulation of neural crest cell differentiation +relationship: regulates GO:0014036 ! neural crest cell fate specification + +[Term] +id: GO:1905296 +name: negative regulation of neural crest cell fate specification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +synonym: "down regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +synonym: "down-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +synonym: "downregulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +synonym: "inhibition of neural crest cell fate specification" NARROW [GOC:TermGenie] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:0090301 ! negative regulation of neural crest formation +is_a: GO:1905293 ! negative regulation of neural crest cell differentiation +is_a: GO:1905295 ! regulation of neural crest cell fate specification +relationship: negatively_regulates GO:0014036 ! neural crest cell fate specification + +[Term] +id: GO:1905297 +name: positive regulation of neural crest cell fate specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15073157] +synonym: "activation of neural crest cell fate specification" NARROW [GOC:TermGenie] +synonym: "up regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +synonym: "up-regulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +synonym: "upregulation of neural crest cell fate specification" EXACT [GOC:TermGenie] +is_a: GO:0042660 ! positive regulation of cell fate specification +is_a: GO:0090300 ! positive regulation of neural crest formation +is_a: GO:1905294 ! positive regulation of neural crest cell differentiation +is_a: GO:1905295 ! regulation of neural crest cell fate specification +relationship: positively_regulates GO:0014036 ! neural crest cell fate specification + +[Term] +id: GO:1905298 +name: regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0060576 ! intestinal epithelial cell development + +[Term] +id: GO:1905299 +name: negative regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +synonym: "down regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "down-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "downregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "inhibition of intestinal epithelial cell development" NARROW [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905298 ! regulation of intestinal epithelial cell development +relationship: negatively_regulates GO:0060576 ! intestinal epithelial cell development + +[Term] +id: GO:1905300 +name: positive regulation of intestinal epithelial cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23904268] +synonym: "activation of intestinal epithelial cell development" NARROW [GOC:TermGenie] +synonym: "up regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "up-regulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +synonym: "upregulation of intestinal epithelial cell development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905298 ! regulation of intestinal epithelial cell development +relationship: positively_regulates GO:0060576 ! intestinal epithelial cell development + +[Term] +id: GO:1905301 +name: regulation of macropinocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] +synonym: "regulation of clathrin-independent pinocytosis" BROAD [GOC:TermGenie] +is_a: GO:0048548 ! regulation of pinocytosis +relationship: regulates GO:0044351 ! macropinocytosis + +[Term] +id: GO:1905302 +name: negative regulation of macropinocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] +synonym: "down regulation of macropinocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of macropinocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of macropinocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of macropinocytosis" NARROW [GOC:TermGenie] +is_a: GO:0048550 ! negative regulation of pinocytosis +is_a: GO:1905301 ! regulation of macropinocytosis +relationship: negatively_regulates GO:0044351 ! macropinocytosis + +[Term] +id: GO:1905303 +name: positive regulation of macropinocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macropinocytosis." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:18691641] +synonym: "activation of macropinocytosis" NARROW [GOC:TermGenie] +synonym: "up regulation of macropinocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of macropinocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of macropinocytosis" EXACT [GOC:TermGenie] +is_a: GO:0048549 ! positive regulation of pinocytosis +is_a: GO:1905301 ! regulation of macropinocytosis +relationship: positively_regulates GO:0044351 ! macropinocytosis + +[Term] +id: GO:1905304 +name: regulation of cardiac myofibril assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] +synonym: "regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +is_a: GO:0060284 ! regulation of cell development +is_a: GO:0110020 ! regulation of actomyosin structure organization +is_a: GO:1902115 ! regulation of organelle assembly +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:0055003 ! cardiac myofibril assembly + +[Term] +id: GO:1905305 +name: negative regulation of cardiac myofibril assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] +synonym: "down regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "down regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of cardiac myofibril assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of cardiac myofibril development" NARROW [GOC:TermGenie] +synonym: "inhibition of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "negative regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +is_a: GO:1905304 ! regulation of cardiac myofibril assembly +is_a: GO:2000726 ! negative regulation of cardiac muscle cell differentiation +relationship: negatively_regulates GO:0055003 ! cardiac myofibril assembly + +[Term] +id: GO:1905306 +name: positive regulation of cardiac myofibril assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16151019] +synonym: "activation of cardiac myofibril assembly" NARROW [GOC:TermGenie] +synonym: "activation of cardiac myofibril development" NARROW [GOC:TermGenie] +synonym: "activation of cardiac myofibril morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "positive regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "up regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of heart myofibril assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of cardiac myofibril assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac myofibril development" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac myofibril morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of heart myofibril assembly" RELATED [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +is_a: GO:1905304 ! regulation of cardiac myofibril assembly +relationship: positively_regulates GO:0055003 ! cardiac myofibril assembly + +[Term] +id: GO:1905307 +name: response to miconazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound + +[Term] +id: GO:1905308 +name: cellular response to miconazole +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26108447] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1905307 ! response to miconazole + +[Term] +id: GO:1905309 +name: positive regulation of cohesin loading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +synonym: "positive regulation of cohesin association with chromatin" EXACT [GOC:TermGenie] +synonym: "positive regulation of cohesin localization to chromatin" EXACT [GOC:TermGenie] +is_a: GO:0071922 ! regulation of cohesin loading +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0120187 ! positive regulation of protein localization to chromatin +relationship: positively_regulates GO:0071921 ! cohesin loading + +[Term] +id: GO:1905310 +name: regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis + +[Term] +id: GO:1905311 +name: negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] +synonym: "down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis +relationship: negatively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis + +[Term] +id: GO:1905312 +name: positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17628518] +synonym: "activation of cardiac neural crest cell migration involved in outflow tract morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:1905310 ! regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis +relationship: positively_regulates GO:0003253 ! cardiac neural crest cell migration involved in outflow tract morphogenesis + +[Term] +id: GO:1905313 +name: transforming growth factor beta receptor signaling pathway involved in heart development +namespace: biological_process +def: "Any transforming growth factor beta receptor signaling pathway that is involved in heart development." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:16140292] +synonym: "TGF-beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "TGF-beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "TGF-beta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "TGF-beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "TGFbeta receptor signaling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "TGFbeta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signaling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signaling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway involved in cardiac development" RELATED [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway involved in dorsal vessel development" NARROW [GOC:TermGenie] +synonym: "transforming growth factor beta receptor signalling pathway involved in heart development" EXACT [GOC:TermGenie] +is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway +is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development + +[Term] +id: GO:1905314 +name: semi-lunar valve development +namespace: biological_process +def: "The process whose specific outcome is the progression of a semi-lunar valve over time, from its formation to the mature structure." [GO_REF:0000094, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19409885] +synonym: "semilunar valve development" EXACT [GOC:TermGenie] +synonym: "semilunar valves development" EXACT [GOC:TermGenie] +is_a: GO:0003170 ! heart valve development + +[Term] +id: GO:1905315 +name: cell proliferation involved in endocardial cushion morphogenesis +namespace: biological_process +def: "Any cell proliferation that is involved in endocardial cushion morphogenesis." [GO_REF:0000060, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:20652948] +is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis +relationship: part_of GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:1905316 +name: superior endocardial cushion morphogenesis +namespace: biological_process +def: "The developmental process by which a superior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629] +synonym: "dorsal endocardial cushion morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:1905317 +name: inferior endocardial cushion morphogenesis +namespace: biological_process +def: "The developmental process by which an inferior endocardial cushion is generated and organized." [GO_REF:0000083, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17050629] +synonym: "ventral endocardial cushion morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0003203 ! endocardial cushion morphogenesis + +[Term] +id: GO:1905318 +name: meiosis I spindle assembly checkpoint signaling +namespace: biological_process +def: "Any spindle assembly checkpoint that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:26483559] +synonym: "meiosis I spindle assembly checkpoint" EXACT [] +is_a: GO:0033316 ! meiotic spindle assembly checkpoint signaling +is_a: GO:0110029 ! negative regulation of meiosis I +relationship: negatively_regulates GO:0051755 ! meiotic sister chromatid arm separation + +[Term] +id: GO:1905319 +name: mesenchymal stem cell migration +namespace: biological_process +def: "The orderly movement of a mesenchymal stem cell from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:24924806, PMID:25181476] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:1905320 +name: regulation of mesenchymal stem cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:1905319 ! mesenchymal stem cell migration + +[Term] +id: GO:1905321 +name: negative regulation of mesenchymal stem cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] +synonym: "down regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +synonym: "downregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +synonym: "inhibition of mesenchymal stem cell migration" NARROW [GOC:TermGenie] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:1905320 ! regulation of mesenchymal stem cell migration +relationship: negatively_regulates GO:1905319 ! mesenchymal stem cell migration + +[Term] +id: GO:1905322 +name: positive regulation of mesenchymal stem cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration." [GO_REF:0000058, GOC:TermGenie, PMID:26846297] +synonym: "activation of mesenchymal stem cell migration" NARROW [GOC:TermGenie] +synonym: "up regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +synonym: "upregulation of mesenchymal stem cell migration" EXACT [GOC:TermGenie] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:1905320 ! regulation of mesenchymal stem cell migration +relationship: positively_regulates GO:1905319 ! mesenchymal stem cell migration + +[Term] +id: GO:1905323 +name: telomerase holoenzyme complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a telomerase holoenzyme complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931] +synonym: "telomerase holoenzyme complex formation" EXACT [GOC:TermGenie] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:1905324 +name: telomere-telomerase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex." [GO_REF:0000079, GOC:TermGenie, PMID:26305931] +synonym: "telomere-telomerase complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065004 ! protein-DNA complex assembly +relationship: part_of GO:0032200 ! telomere organization + +[Term] +id: GO:1905325 +name: regulation of meiosis I spindle assembly checkpoint +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559] +is_a: GO:0060631 ! regulation of meiosis I +is_a: GO:0090231 ! regulation of spindle checkpoint +is_a: GO:1902102 ! regulation of metaphase/anaphase transition of meiotic cell cycle +relationship: regulates GO:1905318 ! meiosis I spindle assembly checkpoint signaling + +[Term] +id: GO:1905326 +name: positive regulation of meiosis I spindle assembly checkpoint +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:26483559] +synonym: "activation of meiosis I spindle assembly checkpoint" NARROW [GOC:TermGenie] +synonym: "up regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] +synonym: "up-regulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] +synonym: "upregulation of meiosis I spindle assembly checkpoint" EXACT [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0090232 ! positive regulation of spindle checkpoint +is_a: GO:1905325 ! regulation of meiosis I spindle assembly checkpoint +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:1905318 ! meiosis I spindle assembly checkpoint signaling + +[Term] +id: GO:1905327 +name: tracheoesophageal septum formation +namespace: biological_process +def: "The process that gives rise to the tracheoesophageal septum. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:TermGenie, PMID:9731532] +synonym: "esophagotracheal septum formation" EXACT [GOC:TermGenie] +synonym: "tracheoesophageal ridges formation" RELATED [GOC:TermGenie] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:1905328 +name: plant septum development +namespace: biological_process +def: "The process whose specific outcome is the progression of a septum over time, from its formation to the mature structure." [GO_REF:0000080, GOC:tb, GOC:TermGenie, PMID:4562349] +synonym: "dissepiment development" BROAD [GOC:TermGenie] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1905329 +name: sphingoid long-chain base transport +namespace: biological_process +def: "The directed movement of a sphingoid long-chain base, sometimes referred to as long-chain base, or sphingoid base, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sphingoid long-chain bases are long-chain aliphatic amines that are the fundamental building blocks of sphingolipids. The main mammalian sphingoid long-chain bases are dihydrosphingosine and sphingosine, while dihydrosphingosine and phytosphingosine are the main sphingoid long-chain bases in yeast." [GO_REF:0000065, GOC:rn, GOC:TermGenie, PMID:27136724] +synonym: "dihydrosphingosine transport" NARROW [] +synonym: "long-chain base transport" RELATED [] +synonym: "phytosphingosine transport" NARROW [] +synonym: "sphingoid base(1+) transport" EXACT [] +synonym: "sphingoid transport" RELATED [] +synonym: "sphingosine transport" NARROW [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0015695 ! organic cation transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:1905330 +name: regulation of morphogenesis of an epithelium +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +synonym: "regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:1905331 +name: negative regulation of morphogenesis of an epithelium +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +synonym: "down regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +synonym: "down-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +synonym: "downregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +synonym: "inhibition of epithelium morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of morphogenesis of an epithelium" NARROW [GOC:TermGenie] +synonym: "negative regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:1905332 +name: positive regulation of morphogenesis of an epithelium +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25745997] +comment: An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). +synonym: "activation of epithelium morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of morphogenesis of an epithelium" NARROW [GOC:TermGenie] +synonym: "positive regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +synonym: "up-regulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +synonym: "upregulation of epithelium morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of morphogenesis of an epithelium" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0002009 ! morphogenesis of an epithelium + +[Term] +id: GO:1905333 +name: regulation of gastric motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gastric motility." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:9924029] +is_a: GO:0044058 ! regulation of digestive system process +relationship: regulates GO:0035482 ! gastric motility + +[Term] +id: GO:1905334 +name: Swi5-Sfr1 complex binding +namespace: molecular_function +def: "Binding to a Swi5-Sfr1 complex." [GOC:TermGenie, PMID:16921379] +synonym: "Sae3-Mei5 complex binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1905335 +name: regulation of aggrephagy +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] +is_a: GO:0016241 ! regulation of macroautophagy +relationship: regulates GO:0035973 ! aggrephagy + +[Term] +id: GO:1905336 +name: negative regulation of aggrephagy +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] +synonym: "down regulation of aggrephagy" EXACT [GOC:TermGenie] +synonym: "down-regulation of aggrephagy" EXACT [GOC:TermGenie] +synonym: "downregulation of aggrephagy" EXACT [GOC:TermGenie] +synonym: "inhibition of aggrephagy" NARROW [GOC:TermGenie] +is_a: GO:0016242 ! negative regulation of macroautophagy +is_a: GO:1905335 ! regulation of aggrephagy +relationship: negatively_regulates GO:0035973 ! aggrephagy + +[Term] +id: GO:1905337 +name: positive regulation of aggrephagy +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aggrephagy." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25686248] +synonym: "activation of aggrephagy" NARROW [GOC:TermGenie] +synonym: "up regulation of aggrephagy" EXACT [GOC:TermGenie] +synonym: "up-regulation of aggrephagy" EXACT [GOC:TermGenie] +synonym: "upregulation of aggrephagy" EXACT [GOC:TermGenie] +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:1905335 ! regulation of aggrephagy +relationship: positively_regulates GO:0035973 ! aggrephagy + +[Term] +id: GO:1905338 +name: negative regulation of cohesin unloading +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +synonym: "down regulation of cohesin unloading" EXACT [GOC:TermGenie] +synonym: "down-regulation of cohesin unloading" EXACT [GOC:TermGenie] +synonym: "downregulation of cohesin unloading" EXACT [GOC:TermGenie] +synonym: "inhibition of cohesin unloading" NARROW [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:0045876 ! positive regulation of sister chromatid cohesion +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1905343 ! regulation of cohesin unloading +relationship: negatively_regulates GO:0061774 ! cohesin unloading + +[Term] +id: GO:1905339 +name: positive regulation of cohesin unloading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +synonym: "activation of cohesin unloading" NARROW [GOC:TermGenie] +synonym: "up regulation of cohesin unloading" EXACT [GOC:TermGenie] +synonym: "up-regulation of cohesin unloading" EXACT [GOC:TermGenie] +synonym: "upregulation of cohesin unloading" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1905343 ! regulation of cohesin unloading +relationship: positively_regulates GO:0061774 ! cohesin unloading + +[Term] +id: GO:1905340 +name: regulation of protein localization to kinetochore +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] +comment: Q9H211 in Human in PMID:22581055 +synonym: "regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0034501 ! protein localization to kinetochore + +[Term] +id: GO:1905341 +name: negative regulation of protein localization to kinetochore +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] +comment: Q9H211 in Human in PMID:22581055 +synonym: "down regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "down regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +synonym: "down-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "down-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +synonym: "downregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "downregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +synonym: "inhibition of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to kinetochore" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "negative regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905340 ! regulation of protein localization to kinetochore +relationship: negatively_regulates GO:0034501 ! protein localization to kinetochore + +[Term] +id: GO:1905342 +name: positive regulation of protein localization to kinetochore +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore." [GO_REF:0000058, GOC:TermGenie, PMID:22581055] +comment: Q9H211 in Human in PMID:22581055 +synonym: "activation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to kinetochore" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "positive regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "up regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "up regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +synonym: "up-regulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "up-regulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +synonym: "upregulation of condensin localization to kinetochore" NARROW [GOC:TermGenie] +synonym: "upregulation of protein localisation to kinetochore" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to kinetochore" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905340 ! regulation of protein localization to kinetochore +relationship: positively_regulates GO:0034501 ! protein localization to kinetochore + +[Term] +id: GO:1905343 +name: regulation of cohesin unloading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:0007063 ! regulation of sister chromatid cohesion +is_a: GO:0051101 ! regulation of DNA binding +relationship: regulates GO:0061774 ! cohesin unloading + +[Term] +id: GO:1905344 +name: prostaglandin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of prostaglandin." [GO_REF:0000068, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:25290914] +synonym: "prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "prostaglandin degradation" EXACT [GOC:TermGenie] +is_a: GO:0062232 ! prostanoid catabolic process + +[Term] +id: GO:1905345 +name: protein localization to cleavage furrow +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow." [GO_REF:0000087, GOC:TermGenie, PMID:27082518] +synonym: "protein localisation in cleavage furrow" EXACT [GOC:TermGenie] +synonym: "protein localisation to cleavage furrow" EXACT [GOC:TermGenie] +synonym: "protein localization in cleavage furrow" EXACT [GOC:TermGenie] +is_a: GO:0072657 ! protein localization to membrane +is_a: GO:0072741 ! protein localization to cell division site +is_a: GO:1990778 ! protein localization to cell periphery + +[Term] +id: GO:1905346 +name: protein localization to cleavage furrow rim +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cleavage furrow rim." [GO_REF:0000087, GOC:TermGenie, PMID:27082518] +synonym: "protein localisation in cleavage furrow rim" EXACT [GOC:TermGenie] +synonym: "protein localisation to cleavage furrow rim" EXACT [GOC:TermGenie] +synonym: "protein localization in cleavage furrow rim" EXACT [GOC:TermGenie] +is_a: GO:1905345 ! protein localization to cleavage furrow + +[Term] +id: GO:1905347 +name: endodeoxyribonuclease complex +namespace: cellular_component +def: "A protein complex which is capable of endodeoxyribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719] +comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay). +synonym: "Mus81-Eme1 complex" NARROW [] +synonym: "Mus81-Eme2 complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905348 +name: endonuclease complex +namespace: cellular_component +def: "A protein complex which is capable of endonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719] +comment: An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay). +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905349 +name: ciliary transition zone assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:21725307, PMID:23644468, PMID:24448408, PMID:26595381, PMID:26982032] +synonym: "cilial transition zone assembly" EXACT [GOC:TermGenie] +synonym: "cilial transition zone formation" EXACT [GOC:TermGenie] +synonym: "ciliary transition zone formation" EXACT [GOC:TermGenie] +synonym: "cilium transition zone assembly" EXACT [GOC:TermGenie] +synonym: "cilium transition zone formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +relationship: part_of GO:0060271 ! cilium assembly + +[Term] +id: GO:1905350 +name: Y-shaped link assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:23728985, PMID:24664739, PMID:26595381, PMID:4554367] +synonym: "membrane-microtubule complex assembly" RELATED [GOC:TermGenie] +synonym: "membrane-microtubule complex formation" RELATED [GOC:TermGenie] +synonym: "Y-link assembly" RELATED [GOC:TermGenie] +synonym: "Y-link formation" RELATED [GOC:TermGenie] +synonym: "Y-link structure assembly" RELATED [GOC:TermGenie] +synonym: "Y-link structure formation" RELATED [GOC:TermGenie] +synonym: "Y-shaped assemblage assembly" RELATED [GOC:TermGenie] +synonym: "Y-shaped assemblage formation" RELATED [GOC:TermGenie] +synonym: "Y-shaped fiber assembly" RELATED [GOC:TermGenie] +synonym: "Y-shaped fiber formation" RELATED [GOC:TermGenie] +synonym: "Y-shaped fibre assembly" RELATED [GOC:TermGenie] +synonym: "Y-shaped fibre formation" RELATED [GOC:TermGenie] +synonym: "Y-shaped link formation" EXACT [GOC:TermGenie] +synonym: "Y-shaped linker assembly" RELATED [GOC:TermGenie] +synonym: "Y-shaped linker formation" RELATED [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905351 +name: pericyte cell migration +namespace: biological_process +def: "The orderly movement of a pericyte cell from one site to another." [GO_REF:0000091, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26268439] +is_a: GO:0016477 ! cell migration + +[Term] +id: GO:1905352 +name: ciliary necklace assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary necklace." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:20399632, PMID:6409906] +synonym: "cilial necklace assembly" EXACT [GOC:TermGenie] +synonym: "cilial necklace formation" EXACT [GOC:TermGenie] +synonym: "ciliary necklace formation" EXACT [GOC:TermGenie] +synonym: "cilium necklace assembly" EXACT [GOC:TermGenie] +synonym: "cilium necklace formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905353 +name: ciliary transition fiber assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary transition fiber." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:24189274] +synonym: "centriolar distal appendage assembly" RELATED [GOC:TermGenie] +synonym: "centriolar distal appendage formation" RELATED [GOC:TermGenie] +synonym: "cilial transition fiber assembly" EXACT [GOC:TermGenie] +synonym: "cilial transition fiber formation" EXACT [GOC:TermGenie] +synonym: "cilial transition fibre assembly" EXACT [GOC:TermGenie] +synonym: "cilial transition fibre formation" EXACT [GOC:TermGenie] +synonym: "ciliary transition fiber formation" EXACT [GOC:TermGenie] +synonym: "ciliary transition fibre assembly" EXACT [GOC:TermGenie] +synonym: "ciliary transition fibre formation" EXACT [GOC:TermGenie] +synonym: "cilium transition fiber assembly" EXACT [GOC:TermGenie] +synonym: "cilium transition fiber formation" EXACT [GOC:TermGenie] +synonym: "cilium transition fibre assembly" EXACT [GOC:TermGenie] +synonym: "cilium transition fibre formation" EXACT [GOC:TermGenie] +synonym: "distal appendage of basal body assembly" RELATED [GOC:TermGenie] +synonym: "distal appendage of basal body formation" RELATED [GOC:TermGenie] +synonym: "distal appendage of centriole assembly" RELATED [GOC:TermGenie] +synonym: "distal appendage of centriole formation" RELATED [GOC:TermGenie] +synonym: "distal appendage of mother centriole assembly" RELATED [GOC:TermGenie] +synonym: "distal appendage of mother centriole formation" RELATED [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905354 +name: exoribonuclease complex +namespace: cellular_component +def: "A protein complex which is capable of exoribonuclease activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896] +comment: An example of this is DIS3 in human (Q9Y2L1) in PMID:17174896 (inferred from direct assay). +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905355 +name: spine apparatus assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a spine apparatus." [GO_REF:0000079, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12928494] +synonym: "dense material assembly" NARROW [GOC:TermGenie] +synonym: "dense material formation" NARROW [GOC:TermGenie] +synonym: "spine apparatus formation" EXACT [GOC:TermGenie] +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:1905356 +name: regulation of snRNA pseudouridine synthesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0031120 ! snRNA pseudouridine synthesis + +[Term] +id: GO:1905357 +name: negative regulation of snRNA pseudouridine synthesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] +synonym: "down regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis +relationship: negatively_regulates GO:0031120 ! snRNA pseudouridine synthesis + +[Term] +id: GO:1905358 +name: positive regulation of snRNA pseudouridine synthesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of snRNA pseudouridine synthesis." [GO_REF:0000058, GOC:TermGenie, PMID:27268497] +synonym: "activation of snRNA pseudouridine synthesis" NARROW [GOC:TermGenie] +synonym: "up regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of snRNA pseudouridine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:1905356 ! regulation of snRNA pseudouridine synthesis +relationship: positively_regulates GO:0031120 ! snRNA pseudouridine synthesis + +[Term] +id: GO:1905359 +name: protein localization to meiotic spindle +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle." [GO_REF:0000087, GOC:TermGenie, PMID:26696398] +synonym: "protein localisation to meiotic spindle" EXACT [GOC:TermGenie] +is_a: GO:0072698 ! protein localization to microtubule cytoskeleton + +[Term] +id: GO:1905360 +name: GTPase complex +namespace: cellular_component +def: "A protein complex which is capable of GTPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006] +comment: An example of this is HRAS in human (P01112) in PMID:9178006 (inferred from direct assay). +synonym: "HRAS-SOS1 complex" NARROW [] +synonym: "RASH-SOS1 complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905362 +name: negative regulation of endosomal vesicle fusion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "down regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "down regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "inhibition of endosomal vesicle fusion" NARROW [GOC:TermGenie] +synonym: "inhibition of endosome vesicle fusion" NARROW [GOC:TermGenie] +synonym: "negative regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +is_a: GO:0031339 ! negative regulation of vesicle fusion +is_a: GO:1905364 ! regulation of endosomal vesicle fusion +relationship: negatively_regulates GO:0034058 ! endosomal vesicle fusion + +[Term] +id: GO:1905363 +name: positive regulation of endosomal vesicle fusion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "activation of endosomal vesicle fusion" NARROW [GOC:TermGenie] +synonym: "activation of endosome vesicle fusion" NARROW [GOC:TermGenie] +synonym: "positive regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of endosomal vesicle fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +is_a: GO:0031340 ! positive regulation of vesicle fusion +is_a: GO:1905364 ! regulation of endosomal vesicle fusion +relationship: positively_regulates GO:0034058 ! endosomal vesicle fusion + +[Term] +id: GO:1905364 +name: regulation of endosomal vesicle fusion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endosomal vesicle fusion." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "regulation of endosome vesicle fusion" EXACT [GOC:TermGenie] +is_a: GO:0031338 ! regulation of vesicle fusion +relationship: regulates GO:0034058 ! endosomal vesicle fusion + +[Term] +id: GO:1905365 +name: regulation of intralumenal vesicle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "regulation of endosome membrane budding" EXACT [GOC:TermGenie] +is_a: GO:1904978 ! regulation of endosome organization +relationship: regulates GO:0070676 ! intralumenal vesicle formation + +[Term] +id: GO:1905366 +name: negative regulation of intralumenal vesicle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "down regulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "down regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "down-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "downregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +synonym: "inhibition of endosome membrane budding" NARROW [GOC:TermGenie] +synonym: "inhibition of intralumenal vesicle formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of endosome membrane budding" EXACT [GOC:TermGenie] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:1904979 ! negative regulation of endosome organization +is_a: GO:1905365 ! regulation of intralumenal vesicle formation +relationship: negatively_regulates GO:0070676 ! intralumenal vesicle formation + +[Term] +id: GO:1905367 +name: positive regulation of intralumenal vesicle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "activation of endosome membrane budding" NARROW [GOC:TermGenie] +synonym: "activation of intralumenal vesicle formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "up regulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "up regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "up-regulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of endosome membrane budding" EXACT [GOC:TermGenie] +synonym: "upregulation of intralumenal vesicle formation" EXACT [GOC:TermGenie] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:1904980 ! positive regulation of endosome organization +is_a: GO:1905365 ! regulation of intralumenal vesicle formation +relationship: positively_regulates GO:0070676 ! intralumenal vesicle formation + +[Term] +id: GO:1905368 +name: peptidase complex +namespace: cellular_component +def: "A protein complex which is capable of peptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] +comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). +synonym: "protease complex" EXACT [] +synonym: "tryptase complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905369 +name: endopeptidase complex +namespace: cellular_component +def: "A protein complex which is capable of endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] +comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:1905370 +name: serine-type endopeptidase complex +namespace: cellular_component +def: "A protein complex which is capable of serine-type endopeptidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240] +comment: An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). +is_a: GO:1905286 ! serine-type peptidase complex +is_a: GO:1905369 ! endopeptidase complex + +[Term] +id: GO:1905371 +name: ceramide phosphoethanolamine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] +synonym: "ceramide phosphoethanolamine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006644 ! phospholipid metabolic process +is_a: GO:0006665 ! sphingolipid metabolic process + +[Term] +id: GO:1905372 +name: ceramide phosphoethanolamine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] +synonym: "ceramide phosphoethanolamine breakdown" EXACT [GOC:TermGenie] +synonym: "ceramide phosphoethanolamine catabolism" EXACT [GOC:TermGenie] +synonym: "ceramide phosphoethanolamine degradation" EXACT [GOC:TermGenie] +is_a: GO:0009395 ! phospholipid catabolic process +is_a: GO:0030149 ! sphingolipid catabolic process +is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process + +[Term] +id: GO:1905373 +name: ceramide phosphoethanolamine biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of ceramide phosphoethanolamine." [GO_REF:0000068, GOC:hjd, GOC:TermGenie, PMID:25667419] +synonym: "ceramide phosphoethanolamine anabolism" EXACT [GOC:TermGenie] +synonym: "ceramide phosphoethanolamine biosynthesis" EXACT [GOC:TermGenie] +synonym: "ceramide phosphoethanolamine formation" EXACT [GOC:TermGenie] +synonym: "ceramide phosphoethanolamine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0008654 ! phospholipid biosynthetic process +is_a: GO:0030148 ! sphingolipid biosynthetic process +is_a: GO:1905371 ! ceramide phosphoethanolamine metabolic process + +[Term] +id: GO:1905374 +name: response to homocysteine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473] +synonym: "response to 2-amino-4-mercaptobutyric acid" EXACT [] +synonym: "response to 2-amino-4-sulfanylbutanoic acid" EXACT [] +synonym: "response to Hcy" EXACT [] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1905375 +name: cellular response to homocysteine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a homocysteine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26722473] +synonym: "cellular response to 2-amino-4-mercaptobutyric acid" EXACT [] +synonym: "cellular response to 2-amino-4-sulfanylbutanoic acid" EXACT [] +synonym: "cellular response to Hcy" EXACT [] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1905374 ! response to homocysteine + +[Term] +id: GO:1905376 +name: negative regulation of cytochrome-c oxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity." [GO_REF:0000059, GOC:TermGenie, PMID:26722473] +synonym: "down regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "down regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "down regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "down regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "down regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "down regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "down regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "down regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "down-regulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "down-regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "down-regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "down-regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "down-regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "downregulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "downregulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "downregulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "downregulation of cytochrome-c oxidase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "downregulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "downregulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "downregulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "downregulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "inhibition of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "inhibition of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytochrome c oxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "inhibition of cytochrome-c oxidase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "inhibition of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of indophenolase" NARROW [GOC:TermGenie] +synonym: "inhibition of NADH cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "inhibition of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of aa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of ba3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of caa3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of cbb3-type cytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of complex IV (mitochondrial electron transport) activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of cytochrome a3 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytochrome aa3 activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytochrome c oxidase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of cytochrome oxidase activity" RELATED [GOC:TermGenie] +synonym: "negative regulation of ferrocytochrome c oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrocytochrome-c:oxygen oxidoreductase" NARROW [GOC:TermGenie] +synonym: "negative regulation of indophenol oxidase" NARROW [GOC:TermGenie] +synonym: "negative regulation of indophenolase" NARROW [GOC:TermGenie] +synonym: "negative regulation of NADH cytochrome c oxidase" EXACT [GOC:TermGenie] +synonym: "negative regulation of warburg's respiratory enzyme activity" RELATED [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1904733 ! negative regulation of electron transfer activity +is_a: GO:1904959 ! regulation of cytochrome-c oxidase activity + +[Term] +id: GO:1905377 +name: response to D-galactose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574] +synonym: "response to D-Gal" EXACT [] +synonym: "response to D-galacto-hexose" EXACT [] +is_a: GO:0009746 ! response to hexose + +[Term] +id: GO:1905378 +name: cellular response to D-galactose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a D-galactose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:26261574] +synonym: "cellular response to D-Gal" EXACT [] +synonym: "cellular response to D-galacto-hexose" EXACT [] +is_a: GO:0071331 ! cellular response to hexose stimulus +is_a: GO:1905377 ! response to D-galactose + +[Term] +id: GO:1905379 +name: beta-N-acetylhexosaminidase complex +namespace: cellular_component +def: "A protein complex which is capable of beta-N-acetylhexosaminidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:6458607] +comment: An example of this is HEXB in human (UniProt symbol P07686) in PMID:6458607 (inferred from direct assay). +synonym: "HEX A complex" NARROW [] +synonym: "HEX B complex" NARROW [] +synonym: "HEX S complex" NARROW [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1905380 +name: regulation of snRNA transcription by RNA polymerase II +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] +synonym: "regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0140747 ! regulation of ncRNA transcription +relationship: regulates GO:0042795 ! snRNA transcription by RNA polymerase II + +[Term] +id: GO:1905381 +name: negative regulation of snRNA transcription by RNA polymerase II +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] +synonym: "down regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "down regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "down-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "downregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "inhibition of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie] +synonym: "inhibition of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "negative regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "negative regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II +relationship: negatively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II + +[Term] +id: GO:1905382 +name: positive regulation of snRNA transcription by RNA polymerase II +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900] +comment: An example of this is GTF2A1 in human (UniProt symbol P52655) in PMID:10022900 (inferred from direct assay). +synonym: "activation of snRNA transcription from Pol II promoter" NARROW [GOC:TermGenie] +synonym: "activation of snRNA transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] +synonym: "positive regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "positive regulation of snRNA transcription from RNA polymerase II promoter" EXACT [] +synonym: "up regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "up-regulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of snRNA transcription from Pol II promoter" EXACT [GOC:TermGenie] +synonym: "upregulation of snRNA transcription from RNA polymerase II promoter" EXACT [GOC:TermGenie] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +is_a: GO:1905380 ! regulation of snRNA transcription by RNA polymerase II +relationship: positively_regulates GO:0042795 ! snRNA transcription by RNA polymerase II + +[Term] +id: GO:1905383 +name: protein localization to presynapse +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a presynapse." [GO_REF:0000087, GOC:TermGenie, PMID:24449494] +synonym: "protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "recruitment of presynaptic proteins" EXACT [PMID:24449494] +is_a: GO:0035418 ! protein localization to synapse + +[Term] +id: GO:1905384 +name: regulation of protein localization to presynapse +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] +synonym: "regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +is_a: GO:1902473 ! regulation of protein localization to synapse +relationship: regulates GO:1905383 ! protein localization to presynapse + +[Term] +id: GO:1905385 +name: negative regulation of protein localization to presynapse +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] +synonym: "down regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "down regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "down-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "downregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in presynapse" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to presynapse" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in presynapse" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to presynapse" NARROW [GOC:TermGenie] +synonym: "inhibition of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "negative regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905384 ! regulation of protein localization to presynapse +relationship: negatively_regulates GO:1905383 ! protein localization to presynapse + +[Term] +id: GO:1905386 +name: positive regulation of protein localization to presynapse +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to presynapse." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24449494] +synonym: "activation of protein localisation in presynapse" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to presynapse" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in presynapse" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to presynapse" NARROW [GOC:TermGenie] +synonym: "activation of recruitment of presynaptic proteins" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "positive regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "up regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "up-regulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in presynapse" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to presynapse" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in presynapse" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to presynapse" EXACT [GOC:TermGenie] +synonym: "upregulation of recruitment of presynaptic proteins" EXACT [GOC:TermGenie] +is_a: GO:1902474 ! positive regulation of protein localization to synapse +is_a: GO:1905384 ! regulation of protein localization to presynapse +relationship: positively_regulates GO:1905383 ! protein localization to presynapse + +[Term] +id: GO:1905387 +name: response to beta-carotene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696] +synonym: "response to beta,beta-carotene" EXACT [] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1905388 +name: cellular response to beta-carotene +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a beta-carotene stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16771696] +synonym: "cellular response to beta,beta-carotene" EXACT [] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1905387 ! response to beta-carotene + +[Term] +id: GO:1905389 +name: response to leukotriene B4 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734] +synonym: "response to LTB4" EXACT [] +is_a: GO:0070542 ! response to fatty acid + +[Term] +id: GO:1905390 +name: cellular response to leukotriene B4 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:14656734] +synonym: "cellular response to LTB4" EXACT [] +is_a: GO:0071398 ! cellular response to fatty acid +is_a: GO:1905389 ! response to leukotriene B4 + +[Term] +id: GO:1905391 +name: regulation of protein localization to cell division site involved in cell separation after cytokinesis +namespace: biological_process +def: "Any regulation of protein localization to cell division site that is involved in cell separation after cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25411334] +synonym: "regulation of protein localisation to cell division site involved in cell separation after cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to cell division site involved in cell separation following cytokinesis" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to cell division site involved in cytokinetic cell separation" RELATED [GOC:TermGenie] +synonym: "regulation of protein localisation to cell division site involved in mitotic cytokinetic cell separation" EXACT [GOC:TermGenie] +is_a: GO:1901900 ! regulation of protein localization to cell division site +relationship: part_of GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:1905392 +name: plant organ morphogenesis +namespace: biological_process +def: "The developmental process by which a plant organ is generated and organized." [GO_REF:0000083, GOC:tb, GOC:TermGenie] +is_a: GO:0009653 ! anatomical structure morphogenesis +relationship: part_of GO:0099402 ! plant organ development + +[Term] +id: GO:1905393 +name: plant organ formation +namespace: biological_process +def: "The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts." [GO_REF:0000081, GOC:tb, GOC:TermGenie] +is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis + +[Term] +id: GO:1905394 +name: retromer complex binding +namespace: molecular_function +def: "Binding to a retromer complex." [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27385586] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1905395 +name: response to flavonoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905396 +name: cellular response to flavonoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a flavonoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905395 ! response to flavonoid + +[Term] +id: GO:1905397 +name: activated CD8-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an activated CD8-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] +synonym: "activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:1905398 +name: activated CD4-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an activated CD4-positive, alpha-beta T cell." [GO_REF:0000085, GOC:TermGenie, PMID:24187568] +synonym: "activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070231 ! T cell apoptotic process + +[Term] +id: GO:1905399 +name: regulation of activated CD4-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905400 +name: negative regulation of activated CD4-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070233 ! negative regulation of T cell apoptotic process +is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process +relationship: negatively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905401 +name: positive regulation of activated CD4-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activated CD4-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "activation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD4-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070234 ! positive regulation of T cell apoptotic process +is_a: GO:1905399 ! regulation of activated CD4-positive, alpha-beta T cell apoptotic process +relationship: positively_regulates GO:1905398 ! activated CD4-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905402 +name: regulation of activated CD8-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070232 ! regulation of T cell apoptotic process +relationship: regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905403 +name: negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070233 ! negative regulation of T cell apoptotic process +is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process +relationship: negatively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905404 +name: positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of activated CD8-positive, alpha-beta T cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24187568] +synonym: "activation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T-cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T lymphocyte apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T-cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of activated CD8-positive, alpha-beta T-lymphocyte apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0070234 ! positive regulation of T cell apoptotic process +is_a: GO:1905402 ! regulation of activated CD8-positive, alpha-beta T cell apoptotic process +relationship: positively_regulates GO:1905397 ! activated CD8-positive, alpha-beta T cell apoptotic process + +[Term] +id: GO:1905405 +name: regulation of mitotic cohesin loading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:0071922 ! regulation of cohesin loading +relationship: regulates GO:0061780 ! mitotic cohesin loading + +[Term] +id: GO:1905406 +name: positive regulation of mitotic cohesin loading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:1905309 ! positive regulation of cohesin loading +is_a: GO:1905405 ! regulation of mitotic cohesin loading +relationship: positively_regulates GO:0061780 ! mitotic cohesin loading + +[Term] +id: GO:1905407 +name: regulation of creatine transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity + +[Term] +id: GO:1905408 +name: negative regulation of creatine transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] +synonym: "down regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "downregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "inhibition of creatine transmembrane transporter activity" NARROW [GOC:TermGenie] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity + +[Term] +id: GO:1905409 +name: positive regulation of creatine transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of creatine transmembrane transporter activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25531585] +synonym: "activation of creatine transmembrane transporter activity" NARROW [GOC:TermGenie] +synonym: "up regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +synonym: "upregulation of creatine transmembrane transporter activity" EXACT [GOC:TermGenie] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1905407 ! regulation of creatine transmembrane transporter activity + +[Term] +id: GO:1905410 +name: regulation of mitotic cohesin unloading +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:0007346 ! regulation of mitotic cell cycle +is_a: GO:1905343 ! regulation of cohesin unloading +relationship: regulates GO:0061781 ! mitotic cohesin unloading + +[Term] +id: GO:1905411 +name: positive regulation of mitotic cohesin unloading +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic cohesin unloading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:1905339 ! positive regulation of cohesin unloading +is_a: GO:1905410 ! regulation of mitotic cohesin unloading +relationship: positively_regulates GO:0061781 ! mitotic cohesin unloading + +[Term] +id: GO:1905412 +name: negative regulation of mitotic cohesin loading +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cohesin loading." [GO_REF:0000058, GOC:TermGenie, PMID:26687354] +is_a: GO:0071923 ! negative regulation of cohesin loading +is_a: GO:1905405 ! regulation of mitotic cohesin loading +relationship: negatively_regulates GO:0061780 ! mitotic cohesin loading + +[Term] +id: GO:1905413 +name: regulation of dense core granule exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] +synonym: "regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +relationship: regulates GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:1905414 +name: negative regulation of dense core granule exocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of dense core granule exocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of dense core vesicle exocytosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +is_a: GO:0045955 ! negative regulation of calcium ion-dependent exocytosis +is_a: GO:1905413 ! regulation of dense core granule exocytosis +relationship: negatively_regulates GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:1905415 +name: positive regulation of dense core granule exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dense core granule exocytosis." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:18468511] +synonym: "activation of dense core granule exocytosis" NARROW [GOC:TermGenie] +synonym: "activation of dense core vesicle exocytosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core granule exocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core vesicle exocytosis" EXACT [GOC:TermGenie] +is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis +is_a: GO:1905413 ! regulation of dense core granule exocytosis +relationship: positively_regulates GO:1990504 ! dense core granule exocytosis + +[Term] +id: GO:1905416 +name: regulation of amoeboid sperm motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] +synonym: "regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +is_a: GO:2000145 ! regulation of cell motility +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0097723 ! amoeboid sperm motility + +[Term] +id: GO:1905417 +name: negative regulation of amoeboid sperm motility +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] +synonym: "down regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "down regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "down regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "down regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "down-regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "down-regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "down-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "down-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "downregulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "downregulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "downregulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "downregulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "inhibition of ameboid sperm motility" NARROW [GOC:TermGenie] +synonym: "inhibition of ameboid sperm movement" NARROW [GOC:TermGenie] +synonym: "inhibition of amoeboid sperm motility" NARROW [GOC:TermGenie] +synonym: "inhibition of amoeboid sperm movement" NARROW [GOC:TermGenie] +synonym: "negative regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "negative regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "negative regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +is_a: GO:1905416 ! regulation of amoeboid sperm motility +is_a: GO:2000146 ! negative regulation of cell motility +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0097723 ! amoeboid sperm motility + +[Term] +id: GO:1905418 +name: positive regulation of amoeboid sperm motility +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amoeboid sperm motility." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie] +synonym: "activation of ameboid sperm motility" NARROW [GOC:TermGenie] +synonym: "activation of ameboid sperm movement" NARROW [GOC:TermGenie] +synonym: "activation of amoeboid sperm motility" NARROW [GOC:TermGenie] +synonym: "activation of amoeboid sperm movement" NARROW [GOC:TermGenie] +synonym: "positive regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "positive regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "positive regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "up regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "up regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "up regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "up regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "up-regulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "up-regulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "up-regulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "up-regulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +synonym: "upregulation of ameboid sperm motility" EXACT [GOC:TermGenie] +synonym: "upregulation of ameboid sperm movement" EXACT [GOC:TermGenie] +synonym: "upregulation of amoeboid sperm motility" EXACT [GOC:TermGenie] +synonym: "upregulation of amoeboid sperm movement" EXACT [GOC:TermGenie] +is_a: GO:1905416 ! regulation of amoeboid sperm motility +is_a: GO:2000147 ! positive regulation of cell motility +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0097723 ! amoeboid sperm motility + +[Term] +id: GO:1905420 +name: vascular associated smooth muscle cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any vascular smooth muscle cell differentiation that is involved in phenotypic switching." [GO_REF:0000060, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [] +synonym: "VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:0035886 ! vascular associated smooth muscle cell differentiation +is_a: GO:0090679 ! cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905421 +name: regulation of plant organ morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:1905422 +name: negative regulation of plant organ morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] +synonym: "down regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of plant organ morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905421 ! regulation of plant organ morphogenesis +relationship: negatively_regulates GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:1905423 +name: positive regulation of plant organ morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis." [GO_REF:0000058, GOC:tb, GOC:TermGenie] +synonym: "activation of plant organ morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of plant organ morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905421 ! regulation of plant organ morphogenesis +relationship: positively_regulates GO:1905392 ! plant organ morphogenesis + +[Term] +id: GO:1905424 +name: regulation of Wnt-mediated midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647] +synonym: "regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling" RELATED [GOC:bf] +synonym: "regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] +synonym: "regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +is_a: GO:1904956 ! regulation of midbrain dopaminergic neuron differentiation +relationship: regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1905425 +name: negative regulation of Wnt-mediated midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "down regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "down-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "down-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "downregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "downregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "inhibition of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "inhibition of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of midbrain dopaminergic neuron differentiation by negative regulation of Wnt signaling" RELATED [GOC:bf] +synonym: "negative regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] +synonym: "negative regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "negative regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "negative regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:1905424 ! regulation of Wnt-mediated midbrain dopaminergic neuron differentiation +relationship: negatively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1905426 +name: positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17244647] +synonym: "activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wg signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wg signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wg signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wg signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wg signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wg signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signalling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" NARROW [GOC:TermGenie] +synonym: "activation of Wnt signaling pathway involved in mDA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt signaling pathway involved in midbrain DA neurogenesis" NARROW [GOC:TermGenie] +synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" NARROW [GOC:TermGenie] +synonym: "activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" NARROW [GOC:TermGenie] +synonym: "activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "activation of Wnt-mediated midbrain DA neuron differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling" RELATED [GOC:bf] +synonym: "positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:bf] +synonym: "positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "positive regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "up regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "up-regulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" RELATED [GOC:TermGenie] +synonym: "upregulation of Wnt-mediated midbrain DA neuron differentiation" EXACT [GOC:TermGenie] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:1904958 ! positive regulation of midbrain dopaminergic neuron differentiation +is_a: GO:1905424 ! regulation of Wnt-mediated midbrain dopaminergic neuron differentiation +relationship: positively_regulates GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1905427 +name: intracellular signal transduction involved in positive regulation of cell growth +namespace: biological_process +def: "Any intracellular signal transduction that is involved in positive regulation of cell growth." [GO_REF:0000060, GOC:al, GOC:TermGenie, GOC:vw, PMID:15917811] +synonym: "intracellular protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction involved in up regulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction involved in up-regulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction involved in upregulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in positive regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in up regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in up-regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signal transduction pathway involved in upregulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling chain involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signaling chain involved in positive regulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "intracellular signaling chain involved in up regulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in up-regulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signaling chain involved in upregulation of cell growth" EXACT [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in activation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in positive regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in stimulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in up regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in up-regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "intracellular signaling pathway involved in upregulation of cell growth" RELATED [GOC:TermGenie] +synonym: "protein kinase cascade involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "protein kinase cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "protein kinase cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "protein kinase cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "protein kinase cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "protein kinase cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in activation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in positive regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in stimulation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in up regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in up-regulation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transduction via intracellular signaling cascade involved in upregulation of cell growth" RELATED [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in activation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in positive regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in stimulation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in up regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in up-regulation of cell growth" NARROW [GOC:TermGenie] +synonym: "signal transmission via intracellular cascade involved in upregulation of cell growth" NARROW [GOC:TermGenie] +is_a: GO:0035556 ! intracellular signal transduction +relationship: part_of GO:0030307 ! positive regulation of cell growth + +[Term] +id: GO:1905428 +name: regulation of plant organ formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plant organ formation." [GO_REF:0000058, GOC:tb, GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:1905393 ! plant organ formation + +[Term] +id: GO:1905429 +name: response to glycine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] +synonym: "response to aminoacetic acid" EXACT [] +synonym: "response to aminoethanoic acid" EXACT [] +synonym: "response to Gly" EXACT [] +synonym: "response to glycin" EXACT [] +is_a: GO:0043200 ! response to amino acid + +[Term] +id: GO:1905430 +name: cellular response to glycine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18984164] +synonym: "cellular response to aminoacetic acid" EXACT [] +synonym: "cellular response to aminoethanoic acid" EXACT [] +synonym: "cellular response to Gly" EXACT [] +synonym: "cellular response to glycin" EXACT [] +is_a: GO:0071230 ! cellular response to amino acid stimulus +is_a: GO:1905429 ! response to glycine + +[Term] +id: GO:1905431 +name: microcystin transport +namespace: biological_process +def: "The directed movement of a microcystin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GO_REF:0000065, GOC:TermGenie, PMID:26055554] +is_a: GO:0015833 ! peptide transport + +[Term] +id: GO:1905432 +name: regulation of retrograde trans-synaptic signaling by neuropeptide +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] +synonym: "regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +is_a: GO:0099177 ! regulation of trans-synaptic signaling +relationship: regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide + +[Term] +id: GO:1905433 +name: negative regulation of retrograde trans-synaptic signaling by neuropeptide +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] +synonym: "down regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +synonym: "inhibition of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +synonym: "inhibition of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] +synonym: "negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide +relationship: negatively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide + +[Term] +id: GO:1905434 +name: positive regulation of retrograde trans-synaptic signaling by neuropeptide +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19448629] +synonym: "activation of retrograde trans-synaptic signaling by neuropeptide" NARROW [GOC:TermGenie] +synonym: "positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling" RELATED [GOC:bf] +synonym: "up regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde trans-synaptic signaling by neuropeptide" EXACT [GOC:TermGenie] +is_a: GO:0010647 ! positive regulation of cell communication +is_a: GO:0023056 ! positive regulation of signaling +is_a: GO:1905432 ! regulation of retrograde trans-synaptic signaling by neuropeptide +relationship: positively_regulates GO:0099082 ! retrograde trans-synaptic signaling by neuropeptide + +[Term] +id: GO:1905435 +name: regulation of histone H3-K4 trimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +is_a: GO:0051569 ! regulation of histone H3-K4 methylation +relationship: regulates GO:0080182 ! histone H3-K4 trimethylation + +[Term] +id: GO:1905436 +name: negative regulation of histone H3-K4 trimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +synonym: "down regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3-K4 trimethylation" NARROW [GOC:TermGenie] +is_a: GO:0051572 ! negative regulation of histone H3-K4 methylation +is_a: GO:1905435 ! regulation of histone H3-K4 trimethylation +relationship: negatively_regulates GO:0080182 ! histone H3-K4 trimethylation + +[Term] +id: GO:1905437 +name: positive regulation of histone H3-K4 trimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K4 trimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +synonym: "activation of histone H3-K4 trimethylation" NARROW [GOC:TermGenie] +synonym: "up regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K4 trimethylation" EXACT [GOC:TermGenie] +is_a: GO:0051571 ! positive regulation of histone H3-K4 methylation +is_a: GO:1905435 ! regulation of histone H3-K4 trimethylation +relationship: positively_regulates GO:0080182 ! histone H3-K4 trimethylation + +[Term] +id: GO:1905438 +name: non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation +namespace: biological_process +def: "Any non-canonical Wnt signaling pathway that is involved in midbrain dopaminergic neuron differentiation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] +synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "beta-catenin-independent Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signalling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt-activated signaling pathway involved in mDA neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain DA neurogenesis" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation" EXACT [GOC:TermGenie] +synonym: "non-canonical Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production" EXACT [GOC:TermGenie] +is_a: GO:0035567 ! non-canonical Wnt signaling pathway +is_a: GO:1904953 ! Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation + +[Term] +id: GO:1905439 +name: response to chondroitin 6'-sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905440 +name: cellular response to chondroitin 6'-sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 6'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905439 ! response to chondroitin 6'-sulfate + +[Term] +id: GO:1905441 +name: response to chondroitin 4'-sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905442 +name: cellular response to chondroitin 4'-sulfate +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chondroitin 4'-sulfate stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22365850] +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905441 ! response to chondroitin 4'-sulfate + +[Term] +id: GO:1905443 +name: regulation of clathrin coat assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940] +synonym: "regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0048268 ! clathrin coat assembly + +[Term] +id: GO:1905444 +name: negative regulation of clathrin coat assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "down regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of clathrin coat assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin coat assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin coat assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of clathrin cage assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of clathrin coat assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1905443 ! regulation of clathrin coat assembly +relationship: negatively_regulates GO:0048268 ! clathrin coat assembly + +[Term] +id: GO:1905445 +name: positive regulation of clathrin coat assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of clathrin coat assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:15533940] +synonym: "activation of clathrin cage assembly" NARROW [GOC:TermGenie] +synonym: "activation of clathrin coat assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of clathrin coat assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of clathrin coat assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of clathrin cage assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of clathrin coat assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1905443 ! regulation of clathrin coat assembly +relationship: positively_regulates GO:0048268 ! clathrin coat assembly + +[Term] +id: GO:1905446 +name: regulation of mitochondrial ATP synthesis coupled electron transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] +synonym: "regulation of mitochondrial electron transport" BROAD [GOC:TermGenie] +synonym: "regulation of organelle ATP synthesis coupled electron transport" BROAD [GOC:TermGenie] +is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy +relationship: regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:1905447 +name: negative regulation of mitochondrial ATP synthesis coupled electron transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] +synonym: "down regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie] +is_a: GO:0090324 ! negative regulation of oxidative phosphorylation +is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport +relationship: negatively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:1905448 +name: positive regulation of mitochondrial ATP synthesis coupled electron transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23707074] +synonym: "activation of mitochondrial ATP synthesis coupled electron transport" NARROW [GOC:TermGenie] +synonym: "up regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial ATP synthesis coupled electron transport" EXACT [GOC:TermGenie] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1905446 ! regulation of mitochondrial ATP synthesis coupled electron transport +relationship: positively_regulates GO:0042775 ! mitochondrial ATP synthesis coupled electron transport + +[Term] +id: GO:1905449 +name: regulation of Fc-gamma receptor signaling pathway involved in phagocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] +synonym: "regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0060368 ! regulation of Fc receptor mediated stimulatory signaling pathway +relationship: regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis + +[Term] +id: GO:1905450 +name: negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] +synonym: "down regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "down regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "down-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "downregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "inhibition of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie] +synonym: "inhibition of IgG-mediated phagocytosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "negative regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0050765 ! negative regulation of phagocytosis +is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis +relationship: negatively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis + +[Term] +id: GO:1905451 +name: positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis." [GO_REF:0000058, GOC:TermGenie, PMID:18832707] +synonym: "activation of Fc gamma receptor-dependent phagocytosis" NARROW [GOC:TermGenie] +synonym: "activation of Fc-gamma receptor signaling pathway involved in phagocytosis" NARROW [GOC:TermGenie] +synonym: "activation of Fc-gamma receptor signalling pathway involved in phagocytosis" NARROW [GOC:TermGenie] +synonym: "activation of Fcgamma receptor-mediated phagocytosis" NARROW [GOC:TermGenie] +synonym: "activation of IgG-mediated phagocytosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "positive regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "up regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "up-regulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of Fc gamma receptor-dependent phagocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of Fcgamma receptor-mediated phagocytosis" EXACT [GOC:TermGenie] +synonym: "upregulation of IgG-mediated phagocytosis" EXACT [GOC:TermGenie] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:0060369 ! positive regulation of Fc receptor mediated stimulatory signaling pathway +is_a: GO:1905449 ! regulation of Fc-gamma receptor signaling pathway involved in phagocytosis +relationship: positively_regulates GO:0038096 ! Fc-gamma receptor signaling pathway involved in phagocytosis + +[Term] +id: GO:1905452 +name: obsolete canonical Wnt signaling pathway involved in regulation of stem cell proliferation +namespace: biological_process +def: "OBSOLETE. Any canonical Wnt signaling pathway that is involved in regulation of stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "canonical Wnt receptor signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in regulation of stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in regulation of stem cell proliferation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905453 +name: regulation of myeloid progenitor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation +relationship: regulates GO:0002318 ! myeloid progenitor cell differentiation + +[Term] +id: GO:1905454 +name: negative regulation of myeloid progenitor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +synonym: "down regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation +is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation +relationship: negatively_regulates GO:0002318 ! myeloid progenitor cell differentiation + +[Term] +id: GO:1905455 +name: positive regulation of myeloid progenitor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +synonym: "activation of myeloid progenitor cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of myeloid progenitor cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation +is_a: GO:1905453 ! regulation of myeloid progenitor cell differentiation +relationship: positively_regulates GO:0002318 ! myeloid progenitor cell differentiation + +[Term] +id: GO:1905456 +name: regulation of lymphoid progenitor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +is_a: GO:1901532 ! regulation of hematopoietic progenitor cell differentiation +relationship: regulates GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:1905457 +name: negative regulation of lymphoid progenitor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +synonym: "down regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] +is_a: GO:1901533 ! negative regulation of hematopoietic progenitor cell differentiation +is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation +relationship: negatively_regulates GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:1905458 +name: positive regulation of lymphoid progenitor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation." [GO_REF:0000058, GOC:TermGenie, PMID:27010503] +synonym: "activation of lymphoid progenitor cell differentiation" NARROW [GOC:TermGenie] +synonym: "up regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of lymphoid progenitor cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:1901534 ! positive regulation of hematopoietic progenitor cell differentiation +is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation +relationship: positively_regulates GO:0002320 ! lymphoid progenitor cell differentiation + +[Term] +id: GO:1905459 +name: regulation of vascular associated smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] +synonym: "regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0034391 ! regulation of smooth muscle cell apoptotic process +relationship: regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process + +[Term] +id: GO:1905460 +name: negative regulation of vascular associated smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] +synonym: "down regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of VSMC apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0034392 ! negative regulation of smooth muscle cell apoptotic process +is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process +relationship: negatively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process + +[Term] +id: GO:1905461 +name: positive regulation of vascular associated smooth muscle cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:26493107] +synonym: "activation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of vascular associated smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of VSMC apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of VSMC apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of VSMC apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0034393 ! positive regulation of smooth muscle cell apoptotic process +is_a: GO:1905459 ! regulation of vascular associated smooth muscle cell apoptotic process +relationship: positively_regulates GO:1905288 ! vascular associated smooth muscle cell apoptotic process + +[Term] +id: GO:1905462 +name: regulation of DNA duplex unwinding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +synonym: "regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "regulation of duplex DNA melting" EXACT [GOC:TermGenie] +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0032508 ! DNA duplex unwinding + +[Term] +id: GO:1905463 +name: negative regulation of DNA duplex unwinding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +synonym: "down regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "down regulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "downregulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA duplex unwinding" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA unwinding" NARROW [GOC:TermGenie] +synonym: "inhibition of duplex DNA melting" NARROW [GOC:TermGenie] +synonym: "negative regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "negative regulation of duplex DNA melting" EXACT [GOC:TermGenie] +is_a: GO:1905462 ! regulation of DNA duplex unwinding +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0032508 ! DNA duplex unwinding + +[Term] +id: GO:1905464 +name: positive regulation of DNA duplex unwinding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA duplex unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +synonym: "activation of DNA duplex unwinding" NARROW [GOC:TermGenie] +synonym: "activation of DNA unwinding" NARROW [GOC:TermGenie] +synonym: "activation of duplex DNA melting" NARROW [GOC:TermGenie] +synonym: "positive regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "positive regulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "up regulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of duplex DNA melting" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA duplex unwinding" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA unwinding" EXACT [GOC:TermGenie] +synonym: "upregulation of duplex DNA melting" EXACT [GOC:TermGenie] +is_a: GO:1905462 ! regulation of DNA duplex unwinding +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0032508 ! DNA duplex unwinding + +[Term] +id: GO:1905465 +name: regulation of G-quadruplex DNA unwinding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +is_a: GO:0033044 ! regulation of chromosome organization +relationship: regulates GO:0044806 ! G-quadruplex DNA unwinding + +[Term] +id: GO:1905466 +name: negative regulation of G-quadruplex DNA unwinding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +synonym: "down regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +synonym: "downregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +synonym: "inhibition of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie] +is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0044806 ! G-quadruplex DNA unwinding + +[Term] +id: GO:1905467 +name: positive regulation of G-quadruplex DNA unwinding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA unwinding." [GO_REF:0000058, GOC:TermGenie, PMID:26503245] +synonym: "activation of G-quadruplex DNA unwinding" NARROW [GOC:TermGenie] +synonym: "up regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +synonym: "upregulation of G-quadruplex DNA unwinding" EXACT [GOC:TermGenie] +is_a: GO:1905465 ! regulation of G-quadruplex DNA unwinding +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0044806 ! G-quadruplex DNA unwinding + +[Term] +id: GO:1905468 +name: regulation of clathrin-coated pit assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "regulation of coated pit formation" EXACT [GOC:TermGenie] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:1905224 ! clathrin-coated pit assembly + +[Term] +id: GO:1905469 +name: negative regulation of clathrin-coated pit assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:26589353] +synonym: "down regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "down regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "downregulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "inhibition of clathrin-coated pit assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of clathrin-coated pit formation" NARROW [GOC:TermGenie] +synonym: "inhibition of coated pit assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of coated pit formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of coated pit formation" EXACT [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1905468 ! regulation of clathrin-coated pit assembly +relationship: negatively_regulates GO:1905224 ! clathrin-coated pit assembly + +[Term] +id: GO:1905470 +name: positive regulation of clathrin-coated pit assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly." [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] +synonym: "activation of clathrin-coated pit assembly" NARROW [GOC:TermGenie] +synonym: "activation of clathrin-coated pit formation" NARROW [GOC:TermGenie] +synonym: "activation of coated pit assembly" NARROW [GOC:TermGenie] +synonym: "activation of coated pit formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "up regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "up regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of coated pit formation" EXACT [GOC:TermGenie] +synonym: "upregulation of clathrin-coated pit assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of clathrin-coated pit formation" EXACT [GOC:TermGenie] +synonym: "upregulation of coated pit assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of coated pit formation" EXACT [GOC:TermGenie] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905468 ! regulation of clathrin-coated pit assembly +relationship: positively_regulates GO:1905224 ! clathrin-coated pit assembly + +[Term] +id: GO:1905471 +name: regulation of histone H3-K79 dimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +synonym: "regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:2001160 ! regulation of histone H3-K79 methylation +relationship: regulates GO:0097725 ! histone H3-K79 dimethylation + +[Term] +id: GO:1905472 +name: negative regulation of histone H3-K79 dimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +synonym: "down regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "down regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "downregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "inhibition of histone H3 K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone H3-K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "inhibition of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:1905471 ! regulation of histone H3-K79 dimethylation +is_a: GO:2001161 ! negative regulation of histone H3-K79 methylation +relationship: negatively_regulates GO:0097725 ! histone H3-K79 dimethylation + +[Term] +id: GO:1905473 +name: positive regulation of histone H3-K79 dimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K79 dimethylation." [GO_REF:0000058, GOC:TermGenie, PMID:27541139] +synonym: "activation of histone H3 K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "activation of histone H3-K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "activation of histone lysine H3 K79 dimethylation" NARROW [GOC:TermGenie] +synonym: "positive regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "positive regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3 K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone H3-K79 dimethylation" EXACT [GOC:TermGenie] +synonym: "upregulation of histone lysine H3 K79 dimethylation" EXACT [GOC:TermGenie] +is_a: GO:1905471 ! regulation of histone H3-K79 dimethylation +is_a: GO:2001162 ! positive regulation of histone H3-K79 methylation +relationship: positively_regulates GO:0097725 ! histone H3-K79 dimethylation + +[Term] +id: GO:1905474 +name: canonical Wnt signaling pathway involved in stem cell proliferation +namespace: biological_process +def: "Any canonical Wnt signaling pathway that is involved in stem cell proliferation." [GO_REF:0000060, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25640183] +synonym: "canonical Wnt receptor signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "canonical Wnt-activated signaling pathway involved in stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "frizzled-1 receptor signaling pathway involved in stem cell proliferation" NARROW [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signaling pathway via beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] +synonym: "Wnt receptor signalling pathway through beta-catenin involved in stem cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation +relationship: part_of GO:0072089 ! stem cell proliferation + +[Term] +id: GO:1905475 +name: regulation of protein localization to membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in membrane" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1905476 +name: negative regulation of protein localization to membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "down regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in membrane" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in membrane" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: negatively_regulates GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1905477 +name: positive regulation of protein localization to membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to membrane." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:26911690] +synonym: "activation of protein localisation in membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in membrane" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to membrane" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905475 ! regulation of protein localization to membrane +relationship: positively_regulates GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1905478 +name: regulation of glutamate-ammonia ligase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] +synonym: "regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:1905479 +name: negative regulation of glutamate-ammonia ligase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] +synonym: "down regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "down regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glutamine synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie] +synonym: "inhibition of L-glutamine synthetase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "negative regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:0051352 ! negative regulation of ligase activity +is_a: GO:1905478 ! regulation of glutamate-ammonia ligase activity + +[Term] +id: GO:1905480 +name: positive regulation of glutamate-ammonia ligase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamate-ammonia ligase activity." [GO_REF:0000059, GOC:TermGenie, PMID:10377385] +synonym: "activation of glutamate-ammonia ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of glutamine synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of glutamylhydroxamic synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-glutamate:ammonia ligase (ADP-forming)" NARROW [GOC:TermGenie] +synonym: "activation of L-glutamine synthetase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamate-ammonia ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamine synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of glutamylhydroxamic synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamate:ammonia ligase (ADP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamine synthetase activity" EXACT [GOC:TermGenie] +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:1905478 ! regulation of glutamate-ammonia ligase activity + +[Term] +id: GO:1905481 +name: obsolete cytoplasmic sequestering of protein involved in mitotic DNA replication checkpoint +namespace: biological_process +def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic DNA replication checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1905482 +name: obsolete cytoplasmic sequestering of protein involved in G2 DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1905483 +name: regulation of motor neuron migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +is_a: GO:2001222 ! regulation of neuron migration +relationship: regulates GO:0097475 ! motor neuron migration + +[Term] +id: GO:1905484 +name: negative regulation of motor neuron migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "down regulation of motor neuron migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of motor neuron migration" EXACT [GOC:TermGenie] +synonym: "downregulation of motor neuron migration" EXACT [GOC:TermGenie] +synonym: "inhibition of motor neuron migration" NARROW [GOC:TermGenie] +is_a: GO:1905483 ! regulation of motor neuron migration +is_a: GO:2001223 ! negative regulation of neuron migration +relationship: negatively_regulates GO:0097475 ! motor neuron migration + +[Term] +id: GO:1905485 +name: positive regulation of motor neuron migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of motor neuron migration." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "activation of motor neuron migration" NARROW [GOC:TermGenie] +synonym: "up regulation of motor neuron migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of motor neuron migration" EXACT [GOC:TermGenie] +synonym: "upregulation of motor neuron migration" EXACT [GOC:TermGenie] +is_a: GO:1905483 ! regulation of motor neuron migration +is_a: GO:2001224 ! positive regulation of neuron migration +relationship: positively_regulates GO:0097475 ! motor neuron migration + +[Term] +id: GO:1905486 +name: regulation of anterior/posterior axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0033564 ! anterior/posterior axon guidance + +[Term] +id: GO:1905487 +name: negative regulation of anterior/posterior axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "down regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "downregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "inhibition of anterior-posterior axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of anterior/posterior axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie] +synonym: "negative regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "negative regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902668 ! negative regulation of axon guidance +is_a: GO:1905486 ! regulation of anterior/posterior axon guidance +relationship: negatively_regulates GO:0033564 ! anterior/posterior axon guidance + +[Term] +id: GO:1905488 +name: positive regulation of anterior/posterior axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "activation of anterior-posterior axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of anterior/posterior axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of anterior/posterior axon pathfinding" NARROW [GOC:TermGenie] +synonym: "positive regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "positive regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +synonym: "upregulation of anterior-posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of anterior/posterior axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of anterior/posterior axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902669 ! positive regulation of axon guidance +is_a: GO:1905486 ! regulation of anterior/posterior axon guidance +relationship: positively_regulates GO:0033564 ! anterior/posterior axon guidance + +[Term] +id: GO:1905489 +name: regulation of sensory neuron axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0097374 ! sensory neuron axon guidance + +[Term] +id: GO:1905490 +name: negative regulation of sensory neuron axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "down regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "inhibition of sensory neuron axon guidance" NARROW [GOC:TermGenie] +is_a: GO:1902668 ! negative regulation of axon guidance +is_a: GO:1905489 ! regulation of sensory neuron axon guidance +relationship: negatively_regulates GO:0097374 ! sensory neuron axon guidance + +[Term] +id: GO:1905491 +name: positive regulation of sensory neuron axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "activation of sensory neuron axon guidance" NARROW [GOC:TermGenie] +synonym: "up regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of sensory neuron axon guidance" EXACT [GOC:TermGenie] +is_a: GO:1902669 ! positive regulation of axon guidance +is_a: GO:1905489 ! regulation of sensory neuron axon guidance +relationship: positively_regulates GO:0097374 ! sensory neuron axon guidance + +[Term] +id: GO:1905492 +name: positive regulation of branching morphogenesis of a nerve +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve." [GO_REF:0000058, GOC:TermGenie, PMID:16516839] +synonym: "activation of branching morphogenesis of a nerve" NARROW [GOC:TermGenie] +synonym: "up regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] +synonym: "up-regulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] +synonym: "upregulation of branching morphogenesis of a nerve" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve +relationship: positively_regulates GO:0048755 ! branching morphogenesis of a nerve + +[Term] +id: GO:1905493 +name: regulation of G-quadruplex DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +synonym: "regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "regulation of G quartet binding" BROAD [GOC:TermGenie] +synonym: "regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "regulation of G-quartet binding" BROAD [GOC:TermGenie] +synonym: "regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:1905494 +name: negative regulation of G-quadruplex DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +synonym: "down regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of G quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of G quartet DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of G-DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of G-quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of G-quartet DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "inhibition of tetraplex DNA binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:1905493 ! regulation of G-quadruplex DNA binding + +[Term] +id: GO:1905495 +name: positive regulation of G-quadruplex DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of G-quadruplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +synonym: "activation of G quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of G quartet DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of G-DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of G-quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of G-quartet DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of quadruplex DNA binding" NARROW [GOC:TermGenie] +synonym: "activation of tetraplex DNA binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of G quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of G quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of G-DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of G-quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of G-quartet DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of quadruplex DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of tetraplex DNA binding" EXACT [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:1905493 ! regulation of G-quadruplex DNA binding + +[Term] +id: GO:1905496 +name: regulation of triplex DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:1905497 +name: negative regulation of triplex DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +synonym: "down regulation of triplex DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of triplex DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of triplex DNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of triplex DNA binding" NARROW [GOC:TermGenie] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:1905496 ! regulation of triplex DNA binding + +[Term] +id: GO:1905498 +name: positive regulation of triplex DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of triplex DNA binding." [GO_REF:0000059, GOC:TermGenie, PMID:26503245] +synonym: "activation of triplex DNA binding" NARROW [GOC:TermGenie] +synonym: "up regulation of triplex DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of triplex DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of triplex DNA binding" EXACT [GOC:TermGenie] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:1905496 ! regulation of triplex DNA binding + +[Term] +id: GO:1905499 +name: trichome papilla formation +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a trichome papilla." [GO_REF:0000079, GOC:tb, GOC:TermGenie, PMID:24014871] +synonym: "trichome papilla assembly" RELATED [] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0030031 ! cell projection assembly +relationship: part_of GO:0010090 ! trichome morphogenesis + +[Term] +id: GO:1905500 +name: obsolete heteroreceptor complex assembly +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a heteroreceptor complex." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "heteroreceptor complex formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905501 +name: obsolete heteroreceptor complex disassembly +namespace: biological_process +def: "OBSOLETE. The disaggregation of a heteroreceptor complex into its constituent components." [GO_REF:0000079, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:24157794] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905502 +name: acetyl-CoA binding +namespace: molecular_function +def: "Binding to acetyl-CoA, an acyl-CoA having acetyl as its S-acetyl component." [GO_REF:0000067, GOC:bc, GOC:krc, GOC:PARL, GOC:TermGenie, PMID:24927529] +synonym: "acetyl-coenzyme A binding" EXACT [] +is_a: GO:0043168 ! anion binding +is_a: GO:0120227 ! acyl-CoA binding + +[Term] +id: GO:1905503 +name: regulation of motile cilium assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] +synonym: "regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "regulation of motile primary cilium assembly" RELATED [] +synonym: "regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "regulation of nodal cilium formation" RELATED [GOC:TermGenie] +is_a: GO:1902017 ! regulation of cilium assembly +relationship: regulates GO:0044458 ! motile cilium assembly + +[Term] +id: GO:1905504 +name: negative regulation of motile cilium assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] +synonym: "down regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "down regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "down regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "downregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "downregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "downregulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "inhibition of motile primary cilia assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of motile primary cilia formation" NARROW [GOC:TermGenie] +synonym: "inhibition of motile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of motile primary cilium formation" NARROW [GOC:TermGenie] +synonym: "inhibition of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of motile primary cilium assembly" RELATED [] +synonym: "negative regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of nodal cilium formation" RELATED [GOC:TermGenie] +is_a: GO:1902018 ! negative regulation of cilium assembly +is_a: GO:1905503 ! regulation of motile cilium assembly +relationship: negatively_regulates GO:0044458 ! motile cilium assembly + +[Term] +id: GO:1905505 +name: positive regulation of motile cilium assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of motile cilium assembly." [GO_REF:0000058, GOC:cilia, GOC:krc, GOC:TermGenie, PMID:25294941] +synonym: "activation of motile primary cilia assembly" NARROW [GOC:TermGenie] +synonym: "activation of motile primary cilia formation" NARROW [GOC:TermGenie] +synonym: "activation of motile primary cilium assembly" NARROW [GOC:TermGenie] +synonym: "activation of motile primary cilium formation" NARROW [GOC:TermGenie] +synonym: "activation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "activation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of motile primary cilium assembly" RELATED [] +synonym: "positive regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "up regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "up regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "up regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of nodal cilium formation" RELATED [GOC:TermGenie] +synonym: "upregulation of motile primary cilia assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of motile primary cilia formation" RELATED [GOC:TermGenie] +synonym: "upregulation of motile primary cilium assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of motile primary cilium formation" RELATED [GOC:TermGenie] +synonym: "upregulation of nodal cilium assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of nodal cilium formation" RELATED [GOC:TermGenie] +is_a: GO:0045724 ! positive regulation of cilium assembly +is_a: GO:1905503 ! regulation of motile cilium assembly +relationship: positively_regulates GO:0044458 ! motile cilium assembly + +[Term] +id: GO:1905506 +name: gerontoplast stroma +namespace: cellular_component +def: "Any plastid stroma that is part of a gerontoplast." [GO_REF:0000064, GOC:mag, GOC:TermGenie, PMID:11212360] +is_a: GO:0009532 ! plastid stroma +relationship: part_of GO:0034400 ! gerontoplast + +[Term] +id: GO:1905507 +name: obsolete cytoplasmic sequestering of protein involved in mitotic G2 DNA damage checkpoint +namespace: biological_process +def: "OBSOLETE. Any cytoplasmic sequestering of protein that is involved in mitotic G2 DNA damage checkpoint." [GO_REF:0000060, GOC:TermGenie, PMID:10523629] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:1905508 +name: protein localization to microtubule organizing center +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] +synonym: "protein localisation in microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localisation to microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localization in microtubule organizing center" EXACT [GOC:TermGenie] +is_a: GO:0072698 ! protein localization to microtubule cytoskeleton + +[Term] +id: GO:1905509 +name: protein localization to interphase microtubule organizing center +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an interphase microtubule organizing center." [GO_REF:0000087, GOC:TermGenie, PMID:19001497] +synonym: "protein localisation in interphase microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localisation to interphase microtubule organizing center" EXACT [GOC:TermGenie] +synonym: "protein localization in interphase microtubule organizing center" EXACT [GOC:TermGenie] +is_a: GO:1905508 ! protein localization to microtubule organizing center + +[Term] +id: GO:1905510 +name: negative regulation of myosin II filament assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416] +comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules +synonym: "down regulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "down-regulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "downregulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "inhibition of myosin II filament assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "negative regulation of myosin II polymerization" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0043520 ! regulation of myosin II filament assembly +is_a: GO:1904900 ! negative regulation of myosin II filament organization +relationship: negatively_regulates GO:0031036 ! myosin II filament assembly + +[Term] +id: GO:1905511 +name: positive regulation of myosin II filament assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myosin II filament assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27237792, PMID:7691416] +comment: positive regulation / down regulation of the formation of a bipolar filament composed of myosin II molecules +synonym: "activation of myosin II filament assembly" NARROW [GOC:TermGenie] +synonym: "activation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "positive regulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "up regulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "up-regulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of myosin II polymerization" RELATED [GOC:TermGenie] +synonym: "upregulation of myosin II filament assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of myosin II polymerization" RELATED [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0043520 ! regulation of myosin II filament assembly +is_a: GO:1904901 ! positive regulation of myosin II filament organization +relationship: positively_regulates GO:0031036 ! myosin II filament assembly + +[Term] +id: GO:1905512 +name: regulation of short-term synaptic potentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] +synonym: "regulation of synaptic facilitation" EXACT [GOC:TermGenie] +is_a: GO:0048167 ! regulation of synaptic plasticity +relationship: regulates GO:1990926 ! short-term synaptic potentiation + +[Term] +id: GO:1905513 +name: negative regulation of short-term synaptic potentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] +synonym: "down regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "down-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "downregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "inhibition of short-term synaptic potentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of synaptic facilitation" NARROW [GOC:TermGenie] +synonym: "negative regulation of synaptic facilitation" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1905512 ! regulation of short-term synaptic potentiation +relationship: negatively_regulates GO:1990926 ! short-term synaptic potentiation + +[Term] +id: GO:1905514 +name: positive regulation of short-term synaptic potentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of short-term synaptic potentiation." [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:15470145] +synonym: "activation of short-term synaptic potentiation" NARROW [GOC:TermGenie] +synonym: "activation of synaptic facilitation" NARROW [GOC:TermGenie] +synonym: "positive regulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "up regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "up-regulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of synaptic facilitation" EXACT [GOC:TermGenie] +synonym: "upregulation of short-term synaptic potentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of synaptic facilitation" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1905512 ! regulation of short-term synaptic potentiation +relationship: positively_regulates GO:1990926 ! short-term synaptic potentiation + +[Term] +id: GO:1905515 +name: non-motile cilium assembly +namespace: biological_process +alt_id: GO:0035058 +def: "The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium." [GO_REF:0000079, GOC:cilia, GOC:kmv, GOC:TermGenie, PMID:14521833, PMID:14521834] +synonym: "immotile primary cilium assembly" RELATED [GOC:bf] +synonym: "non-motile cilium formation" EXACT [GOC:TermGenie] +synonym: "nonmotile cilium assembly" EXACT [GOC:TermGenie] +synonym: "nonmotile cilium formation" EXACT [GOC:TermGenie] +synonym: "nonmotile primary cilia assembly" RELATED [GOC:bf] +synonym: "nonmotile primary cilium assembly" RELATED [] +synonym: "sensory cilium assembly" RELATED [GOC:kmv] +synonym: "sensory cilium biogenesis" RELATED [GOC:mah] +is_a: GO:0060271 ! cilium assembly + +[Term] +id: GO:1905516 +name: positive regulation of fertilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fertilization." [GO_REF:0000058, GOC:hbye, GOC:TermGenie, PMID:27564576] +synonym: "activation of fertilization" NARROW [GOC:TermGenie] +synonym: "activation of syngamy" NARROW [GOC:TermGenie] +synonym: "positive regulation of syngamy" EXACT [GOC:TermGenie] +synonym: "up regulation of fertilization" EXACT [GOC:TermGenie] +synonym: "up regulation of syngamy" EXACT [GOC:TermGenie] +synonym: "up-regulation of fertilization" EXACT [GOC:TermGenie] +synonym: "up-regulation of syngamy" EXACT [GOC:TermGenie] +synonym: "upregulation of fertilization" EXACT [GOC:TermGenie] +synonym: "upregulation of syngamy" EXACT [GOC:TermGenie] +is_a: GO:0080154 ! regulation of fertilization +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0009566 ! fertilization + +[Term] +id: GO:1905517 +name: macrophage migration +namespace: biological_process +def: "The orderly movement of a macrophage from one site to another." [GO_REF:0000091, GOC:TermGenie, PMID:25749876] +is_a: GO:0097529 ! myeloid leukocyte migration + +[Term] +id: GO:1905518 +name: regulation of presynaptic active zone assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] +synonym: "regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:1904071 ! presynaptic active zone assembly + +[Term] +id: GO:1905519 +name: negative regulation of presynaptic active zone assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] +synonym: "down regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "down regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "down regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "down regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "down-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "downregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "downregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "downregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "inhibition of pre-synaptic active zone assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "inhibition of pre-synaptic active zone formation" NARROW [GOC:TermGenie] +synonym: "inhibition of presynaptic active zone assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of presynaptic active zone formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +is_a: GO:1905518 ! regulation of presynaptic active zone assembly +is_a: GO:1905607 ! negative regulation of presynapse assembly +relationship: negatively_regulates GO:1904071 ! presynaptic active zone assembly + +[Term] +id: GO:1905520 +name: positive regulation of presynaptic active zone assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:15797875] +synonym: "activation of pre-synaptic active zone assembly" NARROW [GOC:TermGenie] +synonym: "activation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "activation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "activation of pre-synaptic active zone formation" NARROW [GOC:TermGenie] +synonym: "activation of presynaptic active zone assembly" NARROW [GOC:TermGenie] +synonym: "activation of presynaptic active zone formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "up regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "up regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "up regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "up-regulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "upregulation of pre-synaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of pre-synaptic active zone component assembly" NARROW [GOC:TermGenie] +synonym: "upregulation of pre-synaptic active zone component formation" NARROW [GOC:TermGenie] +synonym: "upregulation of pre-synaptic active zone formation" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic active zone assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic active zone formation" EXACT [GOC:TermGenie] +is_a: GO:1905518 ! regulation of presynaptic active zone assembly +is_a: GO:1905608 ! positive regulation of presynapse assembly +relationship: positively_regulates GO:1904071 ! presynaptic active zone assembly + +[Term] +id: GO:1905521 +name: regulation of macrophage migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:1905517 ! macrophage migration + +[Term] +id: GO:1905522 +name: negative regulation of macrophage migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] +synonym: "down regulation of macrophage migration" EXACT [GOC:TermGenie] +synonym: "down-regulation of macrophage migration" EXACT [GOC:TermGenie] +synonym: "downregulation of macrophage migration" EXACT [GOC:TermGenie] +synonym: "inhibition of macrophage migration" NARROW [GOC:TermGenie] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:1905521 ! regulation of macrophage migration +relationship: negatively_regulates GO:1905517 ! macrophage migration + +[Term] +id: GO:1905523 +name: positive regulation of macrophage migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage migration." [GO_REF:0000058, GOC:TermGenie, PMID:25749876] +synonym: "activation of macrophage migration" NARROW [GOC:TermGenie] +synonym: "up regulation of macrophage migration" EXACT [GOC:TermGenie] +synonym: "up-regulation of macrophage migration" EXACT [GOC:TermGenie] +synonym: "upregulation of macrophage migration" EXACT [GOC:TermGenie] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:1905521 ! regulation of macrophage migration +relationship: positively_regulates GO:1905517 ! macrophage migration + +[Term] +id: GO:1905524 +name: negative regulation of protein autoubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:17237821] +synonym: "down regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "down regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein autoubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "downregulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "downregulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "inhibition of protein auto-ubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of protein auto-ubiquitinylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein autoubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of protein autoubiquitinylation" NARROW [GOC:TermGenie] +synonym: "inhibition of protein self-ubiquitination" NARROW [GOC:TermGenie] +synonym: "inhibition of protein self-ubiquitinylation" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein auto-ubiquitination" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein auto-ubiquitinylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein autoubiquitinylation" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein self-ubiquitination" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein self-ubiquitinylation" EXACT [GOC:TermGenie] +is_a: GO:0031397 ! negative regulation of protein ubiquitination +is_a: GO:1902498 ! regulation of protein autoubiquitination +relationship: negatively_regulates GO:0051865 ! protein autoubiquitination + +[Term] +id: GO:1905525 +name: obsolete regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "OBSOLETE. A negative regulation of transcription from RNA polymerase II promoter in response to iron that results in regulation of ferrichrome biosynthetic process." [GO_REF:0000063, GOC:TermGenie, PMID:20435771] +comment: This term was made obsolete because it was added in error. +synonym: "regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905526 +name: regulation of Golgi lumen acidification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] +is_a: GO:0032847 ! regulation of cellular pH reduction +relationship: regulates GO:0061795 ! Golgi lumen acidification + +[Term] +id: GO:1905527 +name: negative regulation of Golgi lumen acidification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] +synonym: "down regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +synonym: "down-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +synonym: "downregulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +synonym: "inhibition of Golgi lumen acidification" NARROW [GOC:TermGenie] +is_a: GO:0032848 ! negative regulation of cellular pH reduction +is_a: GO:1905526 ! regulation of Golgi lumen acidification +relationship: negatively_regulates GO:0061795 ! Golgi lumen acidification + +[Term] +id: GO:1905528 +name: positive regulation of Golgi lumen acidification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Golgi lumen acidification." [GO_REF:0000058, GOC:dph, GOC:TermGenie, PMID:23447592] +synonym: "activation of Golgi lumen acidification" NARROW [GOC:TermGenie] +synonym: "up regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +synonym: "up-regulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +synonym: "upregulation of Golgi lumen acidification" EXACT [GOC:TermGenie] +is_a: GO:0032849 ! positive regulation of cellular pH reduction +is_a: GO:1905526 ! regulation of Golgi lumen acidification +relationship: positively_regulates GO:0061795 ! Golgi lumen acidification + +[Term] +id: GO:1905529 +name: regulation of uracil import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] +is_a: GO:0034762 ! regulation of transmembrane transport +relationship: regulates GO:0098721 ! uracil import across plasma membrane + +[Term] +id: GO:1905530 +name: negative regulation of uracil import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:1905529 ! regulation of uracil import across plasma membrane +relationship: negatively_regulates GO:0098721 ! uracil import across plasma membrane + +[Term] +id: GO:1905531 +name: positive regulation of uracil import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of uracil import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:26536126] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:1905529 ! regulation of uracil import across plasma membrane +relationship: positively_regulates GO:0098721 ! uracil import across plasma membrane + +[Term] +id: GO:1905532 +name: regulation of leucine import across plasma membrane +namespace: biological_process +alt_id: GO:1903128 +def: "Any process that modulates the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] +synonym: "regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "regulation of leucine import into cell" EXACT [] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +relationship: regulates GO:0098713 ! leucine import across plasma membrane + +[Term] +id: GO:1905533 +name: negative regulation of leucine import across plasma membrane +namespace: biological_process +alt_id: GO:1903129 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] +synonym: "down regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "down regulation of leucine import into cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "down-regulation of leucine import into cell" EXACT [GOC:TermGenie] +synonym: "downregulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "downregulation of leucine import into cell" EXACT [GOC:TermGenie] +synonym: "inhibition of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "inhibition of leucine import into cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of leucine import into cell" EXACT [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1905532 ! regulation of leucine import across plasma membrane +relationship: negatively_regulates GO:0098713 ! leucine import across plasma membrane + +[Term] +id: GO:1905534 +name: positive regulation of leucine import across plasma membrane +namespace: biological_process +alt_id: GO:1903130 +def: "Any process that activates or increases the frequency, rate or extent of leucine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:10467003] +synonym: "activation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "activation of leucine import into cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of leucine import into cell" EXACT [] +synonym: "up regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "up regulation of leucine import into cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "up-regulation of leucine import into cell" EXACT [GOC:TermGenie] +synonym: "upregulation of L-leucine import into cell" NARROW [GOC:TermGenie] +synonym: "upregulation of leucine import into cell" EXACT [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1905532 ! regulation of leucine import across plasma membrane +relationship: positively_regulates GO:0098713 ! leucine import across plasma membrane + +[Term] +id: GO:1905535 +name: regulation of eukaryotic translation initiation factor 4F complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "regulation of eIF4F assembly" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly + +[Term] +id: GO:1905536 +name: negative regulation of eukaryotic translation initiation factor 4F complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "down regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of eIF-4F assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of eIF4F assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of eIF4F assembly" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly +relationship: negatively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly + +[Term] +id: GO:1905537 +name: positive regulation of eukaryotic translation initiation factor 4F complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "activation of eIF-4F assembly" NARROW [GOC:TermGenie] +synonym: "activation of eIF4F assembly" NARROW [GOC:TermGenie] +synonym: "activation of eukaryotic translation initiation factor 4F complex assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of eIF-4F assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of eIF4F assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of eukaryotic translation initiation factor 4F complex assembly" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1905535 ! regulation of eukaryotic translation initiation factor 4F complex assembly +relationship: positively_regulates GO:0097010 ! eukaryotic translation initiation factor 4F complex assembly + +[Term] +id: GO:1905538 +name: polysome binding +namespace: molecular_function +def: "Binding to a polysome." [GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "polyribosome binding" EXACT [GOC:TermGenie] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:1905539 +name: regulation of postsynapse to nucleus signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway." [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005] +subset: goslim_synapse +synonym: "regulation of postsynaptic signaling to nucleus" EXACT [GOC:TermGenie] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0099527 ! postsynapse to nucleus signaling pathway + +[Term] +id: GO:1905540 +name: interleukin-7 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-7 (IL-7) and that consists of, at a minimum, an interleukin, an alpha and a gamma chain as well as optional additional kinase subunits. The alpha chain binds IL-7 with high affinity and subsequently binds the cytokine receptor common gamma chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:19141282] +comment: An example of this is IL7R in human (P16871) in PMID:19141282 (inferred from direct assay). +synonym: "IL-7 receptor complex" EXACT [] +synonym: "IL-7-receptor complex" EXACT [] +synonym: "IL7 receptor complex" EXACT [] +synonym: "IL7-receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1905541 +name: regulation of L-arginine import across plasma membrane +namespace: biological_process +alt_id: GO:0010963 +alt_id: GO:1902826 +def: "Any process that modulates the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] +synonym: "regulation of L-arginine import" BROAD [] +synonym: "regulation of L-arginine import into cell" EXACT [] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:0097638 ! L-arginine import across plasma membrane + +[Term] +id: GO:1905542 +name: negative regulation of L-arginine import across plasma membrane +namespace: biological_process +alt_id: GO:1902827 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] +synonym: "down regulation of L-arginine import into cell" EXACT [GOC:TermGenie] +synonym: "downregulation of L-arginine import into cell" EXACT [GOC:TermGenie] +synonym: "inhibition of L-arginine import into cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-arginine import into cell" EXACT [] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane +relationship: negatively_regulates GO:0097638 ! L-arginine import across plasma membrane + +[Term] +id: GO:1905543 +name: interleukin-15 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-15 (IL-15) and that consists of, at a minimum, an interleukin, an alpha, beta and gamma chain as well as optional additional kinase subunits. The alpha chain is unique to binds IL-15 while it shares the beta chain with the IL-2 receptor and the cytokine receptor common gamma chain with multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:23104097] +comment: An example of this is IL15RA in human (Q13261) in PMID:23104097 (inferred from physical interaction). +synonym: "IL-15 receptor complex" EXACT [] +synonym: "IL-15-receptor complex" EXACT [] +synonym: "IL15 receptor complex" EXACT [] +synonym: "IL15-receptor complex" EXACT [] +synonym: "interleukin-15-receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1905544 +name: L-methionine import across plasma membrane +namespace: biological_process +alt_id: GO:1903813 +def: "The directed movement of L-methionine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] +synonym: "L-methionine import into cell" EXACT [] +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport +is_a: GO:1903692 ! methionine import across plasma membrane + +[Term] +id: GO:1905545 +name: obsolete negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron." [GO_REF:0000058, GOC:TermGenie, PMID:20435771] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "down-regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "downregulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "inhibition of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome anabolism by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by down-regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by downregulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from Pol II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome biosynthetic process, peptide modification by negative regulation of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome formation by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by down regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by down-regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by downregulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by inhibition of transcription from RNA polymerase II promoter in response to iron" NARROW [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from Pol II promoter in response to iron" EXACT [GOC:TermGenie] +synonym: "negative regulation of regulation of ferrichrome synthesis by negative regulation of transcription from RNA polymerase II promoter in response to iron" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905546 +name: cellular response to phenylpropanoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phenylpropanoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22700048] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0080184 ! response to phenylpropanoid + +[Term] +id: GO:1905547 +name: obsolete regulation of subtelomeric heterochromatin assembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "regulation of telomeric heterochromatin assembly" RELATED [] +synonym: "regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905548 +name: obsolete negative regulation of subtelomeric heterochromatin assembly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "down regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "downregulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "inhibition of telomeric heterochromatin assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of telomeric heterochromatin formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomeric heterochromatin assembly" RELATED [] +synonym: "negative regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905549 +name: obsolete positive regulation of subtelomeric heterochromatin assembly +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of subtelomeric heterochromatin assembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25819580] +comment: This term was obsoleted because there is no evidence that chromatin silencing /heterochromatin assembly are directly regulated. +synonym: "activation of telomeric heterochromatin assembly" NARROW [GOC:TermGenie] +synonym: "activation of telomeric heterochromatin formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomeric heterochromatin assembly" RELATED [] +synonym: "positive regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "up regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +synonym: "upregulation of telomeric heterochromatin assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of telomeric heterochromatin formation" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905550 +name: regulation of protein localization to endoplasmic reticulum +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] +synonym: "regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in ER" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:1905551 +name: negative regulation of protein localization to endoplasmic reticulum +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] +synonym: "down regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in ER" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in ER" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum +relationship: negatively_regulates GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:1905552 +name: positive regulation of protein localization to endoplasmic reticulum +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to endoplasmic reticulum." [GO_REF:0000058, GOC:TermGenie, PMID:22768340] +synonym: "activation of protein localisation in endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in ER" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to endoplasmic reticulum" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in endoplasmic reticulum" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in ER" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to endoplasmic reticulum" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905550 ! regulation of protein localization to endoplasmic reticulum +relationship: positively_regulates GO:0070972 ! protein localization to endoplasmic reticulum + +[Term] +id: GO:1905553 +name: regulation of blood vessel branching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +synonym: "regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0045765 ! regulation of angiogenesis +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905330 ! regulation of morphogenesis of an epithelium +relationship: regulates GO:0001569 ! branching involved in blood vessel morphogenesis + +[Term] +id: GO:1905554 +name: negative regulation of vessel branching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +synonym: "down regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "down-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "downregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "inhibition of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of patterning of blood vessels" NARROW [GOC:TermGenie] +synonym: "negative regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0016525 ! negative regulation of angiogenesis +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +is_a: GO:1905553 ! regulation of blood vessel branching +relationship: negatively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis + +[Term] +id: GO:1905555 +name: positive regulation of blood vessel branching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood vessel branching." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +synonym: "activation of branching involved in blood vessel morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of patterning of blood vessels" NARROW [GOC:TermGenie] +synonym: "positive regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "up-regulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of patterning of blood vessels" EXACT [GOC:TermGenie] +synonym: "upregulation of branching involved in blood vessel morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of patterning of blood vessels" EXACT [GOC:TermGenie] +is_a: GO:0045766 ! positive regulation of angiogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +is_a: GO:1905553 ! regulation of blood vessel branching +relationship: positively_regulates GO:0001569 ! branching involved in blood vessel morphogenesis + +[Term] +id: GO:1905556 +name: ciliary vesicle assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a ciliary vesicle. Multiple smaller vesicles dock to the transitional fibers on a mature basal body and then fuse together to form a larger single vesicle. This then fuses with the plasma membrane and forms the ciliary membrane." [GO_REF:0000079, GOC:cilia, GOC:TermGenie, PMID:13978319, PMID:25313408, PMID:25805133, PMID:25812525] +synonym: "ciliary vesicle formation" EXACT [GOC:TermGenie] +synonym: "CV assembly" RELATED [GOC:TermGenie] +synonym: "CV formation" RELATED [GOC:TermGenie] +synonym: "primary ciliary vesicle assembly" EXACT [GOC:TermGenie] +synonym: "primary ciliary vesicle formation" EXACT [GOC:TermGenie] +is_a: GO:0016050 ! vesicle organization +is_a: GO:0070925 ! organelle assembly + +[Term] +id: GO:1905557 +name: regulation of mitotic nuclear envelope disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] +synonym: "regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +is_a: GO:0010549 ! regulation of membrane disassembly +is_a: GO:0010564 ! regulation of cell cycle process +relationship: regulates GO:0007077 ! mitotic nuclear membrane disassembly + +[Term] +id: GO:1905558 +name: negative regulation of mitotic nuclear envelope disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] +synonym: "down regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "down regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] +synonym: "inhibition of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly +relationship: negatively_regulates GO:0007077 ! mitotic nuclear membrane disassembly + +[Term] +id: GO:1905559 +name: positive regulation of mitotic nuclear envelope disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] +synonym: "activation of mitotic nuclear envelope breakdown" NARROW [GOC:TermGenie] +synonym: "activation of mitotic nuclear envelope catabolism" NARROW [GOC:TermGenie] +synonym: "activation of mitotic nuclear envelope degradation" NARROW [GOC:TermGenie] +synonym: "activation of mitotic nuclear envelope disassembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic nuclear envelope breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic nuclear envelope catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic nuclear envelope degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic nuclear envelope disassembly" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1905557 ! regulation of mitotic nuclear envelope disassembly +relationship: positively_regulates GO:0007077 ! mitotic nuclear membrane disassembly + +[Term] +id: GO:1905560 +name: negative regulation of kinetochore assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] +synonym: "down regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "down regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "down regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "down regulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of kinetochore biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "down-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "down-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "down-regulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "downregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "downregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "downregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "downregulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "inhibition of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "inhibition of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "inhibition of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "inhibition of kinetochore assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "negative regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "negative regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "negative regulation of kinetochore formation" RELATED [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:0090234 ! regulation of kinetochore assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +is_a: GO:2001251 ! negative regulation of chromosome organization +relationship: negatively_regulates GO:0051382 ! kinetochore assembly + +[Term] +id: GO:1905561 +name: positive regulation of kinetochore assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of kinetochore assembly." [GO_REF:0000058, GOC:TermGenie, PMID:18765790] +synonym: "activation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "activation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "activation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "activation of kinetochore assembly" NARROW [GOC:TermGenie] +synonym: "activation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "positive regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "positive regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "positive regulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "up regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "up regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "up regulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "up-regulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "up-regulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "up-regulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of kinetochore formation" RELATED [GOC:TermGenie] +synonym: "upregulation of centromere and kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "upregulation of centromere/kinetochore complex maturation" NARROW [GOC:TermGenie] +synonym: "upregulation of chromosome-kinetochore attachment" NARROW [GOC:TermGenie] +synonym: "upregulation of kinetochore assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of kinetochore formation" RELATED [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:0090234 ! regulation of kinetochore assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0051382 ! kinetochore assembly + +[Term] +id: GO:1905562 +name: regulation of vascular endothelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +is_a: GO:0001936 ! regulation of endothelial cell proliferation +relationship: regulates GO:0101023 ! vascular endothelial cell proliferation + +[Term] +id: GO:1905563 +name: negative regulation of vascular endothelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +synonym: "down regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0001937 ! negative regulation of endothelial cell proliferation +is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation +relationship: negatively_regulates GO:0101023 ! vascular endothelial cell proliferation + +[Term] +id: GO:1905564 +name: positive regulation of vascular endothelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23201774] +synonym: "activation of vascular endothelial cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular endothelial cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0001938 ! positive regulation of endothelial cell proliferation +is_a: GO:1905562 ! regulation of vascular endothelial cell proliferation +relationship: positively_regulates GO:0101023 ! vascular endothelial cell proliferation + +[Term] +id: GO:1905565 +name: obsolete regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905566 +name: obsolete negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905567 +name: obsolete positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of LDL" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905568 +name: regulation of ferrichrome biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie] +synonym: "regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900704 ! regulation of siderophore biosynthetic process +relationship: regulates GO:0031169 ! ferrichrome biosynthetic process + +[Term] +id: GO:1905569 +name: negative regulation of ferrichrome biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321] +synonym: "down regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "downregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "downregulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of ferrichrome anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrichrome synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900705 ! negative regulation of siderophore biosynthetic process +is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process +relationship: negatively_regulates GO:0031169 ! ferrichrome biosynthetic process + +[Term] +id: GO:1905570 +name: positive regulation of ferrichrome biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ferrichrome biosynthetic process." [GO_REF:0000058, GOC:al, GOC:TermGenie, PMID:654321] +synonym: "activation of ferrichrome anabolism" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome formation" NARROW [GOC:TermGenie] +synonym: "activation of ferrichrome synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrichrome anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrichrome biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrichrome biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrichrome biosynthetic process, peptide formation" NARROW [GOC:TermGenie] +synonym: "upregulation of ferrichrome biosynthetic process, peptide modification" NARROW [GOC:TermGenie] +synonym: "upregulation of ferrichrome formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ferrichrome synthesis" EXACT [GOC:TermGenie] +is_a: GO:1900706 ! positive regulation of siderophore biosynthetic process +is_a: GO:1905568 ! regulation of ferrichrome biosynthetic process +relationship: positively_regulates GO:0031169 ! ferrichrome biosynthetic process + +[Term] +id: GO:1905571 +name: interleukin-10 receptor complex +namespace: cellular_component +def: "A protein complex that binds interleukin-10 (IL-10) and that consists of, at a minimum, a dimeric interleukin, an alpha and a beta chain as well as optional additional kinase subunits. The alpha chain binds IL-10 with high affinity and subsequently binds the common beta receptor chain that forms part of multiple interleukin receptors." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16982608] +comment: An example of this is IL10RA in human (UniProt symbol Q13651) in PMID:16982608 (inferred from physical interaction). +synonym: "IL-10 receptor complex" EXACT [] +synonym: "IL-10-receptor complex" EXACT [] +synonym: "IL10 receptor complex" EXACT [] +synonym: "interleukin-10-receptor complex" EXACT [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1905572 +name: ganglioside GM1 transport to membrane +namespace: biological_process +def: "The directed movement of ganglioside GM1 to membrane." [GO_REF:0000078, GOC:TermGenie, PMID:1454804] +is_a: GO:0035627 ! ceramide transport +is_a: GO:0046836 ! glycolipid transport +is_a: GO:0046942 ! carboxylic acid transport +is_a: GO:0051668 ! localization within membrane + +[Term] +id: GO:1905573 +name: ganglioside GM1 binding +namespace: molecular_function +def: "Binding to ganglioside GM1." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0035594 ! ganglioside binding + +[Term] +id: GO:1905574 +name: ganglioside GM2 binding +namespace: molecular_function +def: "Binding to ganglioside GM2." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0035594 ! ganglioside binding + +[Term] +id: GO:1905575 +name: ganglioside GM3 binding +namespace: molecular_function +def: "Binding to ganglioside GM3." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] +is_a: GO:0033293 ! monocarboxylic acid binding +is_a: GO:0035594 ! ganglioside binding + +[Term] +id: GO:1905576 +name: ganglioside GT1b binding +namespace: molecular_function +def: "Binding to ganglioside GT1b." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0035594 ! ganglioside binding + +[Term] +id: GO:1905577 +name: ganglioside GP1c binding +namespace: molecular_function +def: "Binding to ganglioside GP1c." [GO_REF:0000067, GOC:TermGenie, PMID:1454804] +is_a: GO:0031406 ! carboxylic acid binding +is_a: GO:0035594 ! ganglioside binding + +[Term] +id: GO:1905578 +name: regulation of ERBB3 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] +synonym: "regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1901184 ! regulation of ERBB signaling pathway +relationship: regulates GO:0038129 ! ERBB3 signaling pathway + +[Term] +id: GO:1905579 +name: negative regulation of ERBB3 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] +synonym: "down regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "inhibition of ERBB3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of ERBB3 signalling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of HER3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "negative regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "negative regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1901185 ! negative regulation of ERBB signaling pathway +is_a: GO:1905578 ! regulation of ERBB3 signaling pathway +relationship: negatively_regulates GO:0038129 ! ERBB3 signaling pathway + +[Term] +id: GO:1905580 +name: positive regulation of ERBB3 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ERBB3 signaling pathway." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:27353365] +synonym: "activation of ERBB3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of ERBB3 signalling pathway" NARROW [GOC:TermGenie] +synonym: "activation of HER3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "activation of receptor tyrosine-protein kinase erbB-3 signaling pathway" NARROW [GOC:TermGenie] +synonym: "positive regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "positive regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of ERBB3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of ERBB3 signalling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of HER3 signaling pathway" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor tyrosine-protein kinase erbB-3 signaling pathway" EXACT [GOC:TermGenie] +is_a: GO:1901186 ! positive regulation of ERBB signaling pathway +is_a: GO:1905578 ! regulation of ERBB3 signaling pathway +relationship: positively_regulates GO:0038129 ! ERBB3 signaling pathway + +[Term] +id: GO:1905581 +name: positive regulation of low-density lipoprotein particle clearance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "activation of LDL clearance" NARROW [GOC:TermGenie] +synonym: "activation of low-density lipoprotein particle clearance" NARROW [GOC:TermGenie] +synonym: "positive regulation of LDL clearance" EXACT [GOC:TermGenie] +synonym: "up regulation of LDL clearance" EXACT [GOC:TermGenie] +synonym: "up regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] +synonym: "up-regulation of LDL clearance" EXACT [GOC:TermGenie] +synonym: "up-regulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] +synonym: "upregulation of LDL clearance" EXACT [GOC:TermGenie] +synonym: "upregulation of low-density lipoprotein particle clearance" EXACT [GOC:TermGenie] +is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance +is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance +relationship: positively_regulates GO:0034383 ! low-density lipoprotein particle clearance + +[Term] +id: GO:1905582 +name: response to mannose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509] +is_a: GO:0009746 ! response to hexose + +[Term] +id: GO:1905583 +name: cellular response to mannose +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannose stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:16699509] +is_a: GO:0071331 ! cellular response to hexose stimulus +is_a: GO:1905582 ! response to mannose + +[Term] +id: GO:1905584 +name: outer hair cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in an outer hair cell." [GO_REF:0000085, GOC:TermGenie, PMID:12062759, PMID:24472721] +synonym: "cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "outer hair cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0051402 ! neuron apoptotic process + +[Term] +id: GO:1905585 +name: regulation of outer hair cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] +synonym: "regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0043523 ! regulation of neuron apoptotic process +relationship: regulates GO:1905584 ! outer hair cell apoptotic process + +[Term] +id: GO:1905586 +name: negative regulation of outer hair cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] +synonym: "down regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "down-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "downregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "downregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "inhibition of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "inhibition of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "inhibition of outer hair cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "negative regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "negative regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "negative regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +is_a: GO:0043524 ! negative regulation of neuron apoptotic process +is_a: GO:1905585 ! regulation of outer hair cell apoptotic process +relationship: negatively_regulates GO:1905584 ! outer hair cell apoptotic process + +[Term] +id: GO:1905587 +name: positive regulation of outer hair cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of outer hair cell apoptotic process." [GO_REF:0000058, GOC:TermGenie, PMID:24472721] +synonym: "activation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of cochlear outer hair cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "activation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "activation of outer hair cell apoptotic process" NARROW [GOC:TermGenie] +synonym: "positive regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "positive regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "positive regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "up-regulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of cochlear outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of cochlear outer hair cell apoptotic process" EXACT [GOC:TermGenie] +synonym: "upregulation of outer hair cell apoptosis" NARROW [GOC:TermGenie] +synonym: "upregulation of outer hair cell apoptotic process" EXACT [GOC:TermGenie] +is_a: GO:0043525 ! positive regulation of neuron apoptotic process +is_a: GO:1905585 ! regulation of outer hair cell apoptotic process +relationship: positively_regulates GO:1905584 ! outer hair cell apoptotic process + +[Term] +id: GO:1905588 +name: plant-type cell wall modification involved in stomatal movement +namespace: biological_process +def: "Any plant-type cell wall modification that is involved in stomatal movement." [GO_REF:0000060, GOC:TermGenie, PMID:27720618] +synonym: "cellulose and pectin-containing cell wall modification involved in stomatal movement" EXACT [GOC:TermGenie] +is_a: GO:0009827 ! plant-type cell wall modification +relationship: part_of GO:0010118 ! stomatal movement + +[Term] +id: GO:1905589 +name: positive regulation of L-arginine import across plasma membrane +namespace: biological_process +alt_id: GO:1901042 +alt_id: GO:1902828 +def: "Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:14718525] +synonym: "activation of L-arginine import" NARROW [GOC:TermGenie] +synonym: "activation of L-arginine import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "activation of L-arginine import into cell" NARROW [GOC:TermGenie] +synonym: "activation of L-arginine uptake" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-arginine import" BROAD [] +synonym: "positive regulation of L-arginine import into cell" EXACT [] +synonym: "positive regulation of L-arginine uptake" EXACT [GOC:TermGenie] +synonym: "up regulation of L-arginine import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-arginine uptake" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-arginine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-arginine import into cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-arginine uptake" EXACT [GOC:TermGenie] +synonym: "upregulation of L-arginine import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-arginine import into cell" EXACT [GOC:TermGenie] +synonym: "upregulation of L-arginine uptake" EXACT [GOC:TermGenie] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:1905541 ! regulation of L-arginine import across plasma membrane +relationship: positively_regulates GO:0097638 ! L-arginine import across plasma membrane + +[Term] +id: GO:1905590 +name: fibronectin fibril organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a fibronectin fibril." [GOC:dph, GOC:TermGenie, PMID:20690820] +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1905591 +name: regulation of optical nerve axon regeneration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] +is_a: GO:0048679 ! regulation of axon regeneration +relationship: regulates GO:0101027 ! optical nerve axon regeneration + +[Term] +id: GO:1905592 +name: negative regulation of optical nerve axon regeneration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] +synonym: "down regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +synonym: "down-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +synonym: "downregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +synonym: "inhibition of optical nerve axon regeneration" NARROW [GOC:TermGenie] +is_a: GO:0048681 ! negative regulation of axon regeneration +is_a: GO:1905591 ! regulation of optical nerve axon regeneration +relationship: negatively_regulates GO:0101027 ! optical nerve axon regeneration + +[Term] +id: GO:1905593 +name: positive regulation of optical nerve axon regeneration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration." [GO_REF:0000058, GOC:TermGenie, PMID:16699509] +synonym: "activation of optical nerve axon regeneration" NARROW [GOC:TermGenie] +synonym: "up regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +synonym: "up-regulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +synonym: "upregulation of optical nerve axon regeneration" EXACT [GOC:TermGenie] +is_a: GO:0048680 ! positive regulation of axon regeneration +is_a: GO:1905591 ! regulation of optical nerve axon regeneration +relationship: positively_regulates GO:0101027 ! optical nerve axon regeneration + +[Term] +id: GO:1905594 +name: resveratrol binding +namespace: molecular_function +def: "Binding to resveratrol." [GO_REF:0000067, GOC:TermGenie, PMID:18254726] +comment: (5-(aziridin-1-yl)-2,4-dinitrobenzamide +is_a: GO:0097159 ! organic cyclic compound binding + +[Term] +id: GO:1905595 +name: regulation of low-density lipoprotein particle receptor binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +is_a: GO:1900120 ! regulation of receptor binding + +[Term] +id: GO:1905596 +name: negative regulation of low-density lipoprotein particle receptor binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "down regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "down regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "down regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "downregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "inhibition of LDL receptor binding" NARROW [GOC:TermGenie] +synonym: "inhibition of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie] +synonym: "inhibition of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "negative regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +is_a: GO:1900121 ! negative regulation of receptor binding +is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding + +[Term] +id: GO:1905597 +name: positive regulation of low-density lipoprotein particle receptor binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "activation of LDL receptor binding" NARROW [GOC:TermGenie] +synonym: "activation of low-density lipoprotein particle receptor binding" NARROW [GOC:TermGenie] +synonym: "activation of low-density lipoprotein receptor binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "positive regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "up regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "up regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "up regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of LDL receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of low-density lipoprotein particle receptor binding" EXACT [GOC:TermGenie] +synonym: "upregulation of low-density lipoprotein receptor binding" EXACT [GOC:TermGenie] +is_a: GO:1900122 ! positive regulation of receptor binding +is_a: GO:1905595 ! regulation of low-density lipoprotein particle receptor binding + +[Term] +id: GO:1905598 +name: negative regulation of low-density lipoprotein receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "down regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "down regulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "down regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "down-regulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +synonym: "downregulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "downregulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "downregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +synonym: "inhibition of LDL receptor" NARROW [GOC:TermGenie] +synonym: "inhibition of LDLR activity" NARROW [GOC:TermGenie] +synonym: "inhibition of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "negative regulation of LDLR activity" EXACT [GOC:TermGenie] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis + +[Term] +id: GO:1905599 +name: positive regulation of low-density lipoprotein receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity." [GO_REF:0000059, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "activation of LDL receptor" NARROW [GOC:TermGenie] +synonym: "activation of LDLR activity" NARROW [GOC:TermGenie] +synonym: "activation of low-density lipoprotein receptor activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "positive regulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "up regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "up regulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "up regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "up-regulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +synonym: "upregulation of LDL receptor" EXACT [GOC:TermGenie] +synonym: "upregulation of LDLR activity" EXACT [GOC:TermGenie] +synonym: "upregulation of low-density lipoprotein receptor activity" EXACT [GOC:TermGenie] +is_a: GO:0044093 ! positive regulation of molecular function + +[Term] +id: GO:1905600 +name: regulation of receptor-mediated endocytosis involved in cholesterol transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport + +[Term] +id: GO:1905601 +name: negative regulation of receptor-mediated endocytosis involved in cholesterol transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "down regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +is_a: GO:0032384 ! negative regulation of intracellular cholesterol transport +is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis +is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport +relationship: negatively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport + +[Term] +id: GO:1905602 +name: positive regulation of receptor-mediated endocytosis involved in cholesterol transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." [GO_REF:0000058, GOC:BHF, GOC:nc, GOC:TermGenie, PMID:22848640] +synonym: "activation of receptor-mediated endocytosis involved in cholesterol transport" NARROW [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis of LDL" NARROW [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis involved in cholesterol transport" EXACT [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of LDL" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport" RELATED [GOC:TermGenie] +synonym: "upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport" RELATED [GOC:TermGenie] +is_a: GO:0032385 ! positive regulation of intracellular cholesterol transport +is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis +is_a: GO:1905600 ! regulation of receptor-mediated endocytosis involved in cholesterol transport +relationship: positively_regulates GO:0090118 ! receptor-mediated endocytosis involved in cholesterol transport + +[Term] +id: GO:1905603 +name: regulation of blood-brain barrier permeability +namespace: biological_process +def: "Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653] +synonym: "regulation of BBB permeability" EXACT [] +synonym: "regulation of blood/brain barrier permeability" EXACT [] +is_a: GO:0043114 ! regulation of vascular permeability +relationship: part_of GO:0035633 ! maintenance of blood-brain barrier + +[Term] +id: GO:1905604 +name: negative regulation of blood-brain barrier permeability +namespace: biological_process +def: "Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653] +synonym: "down-regulation of BBB permeability" EXACT [] +synonym: "down-regulation of blood-brain barrier permeability" EXACT [] +synonym: "down-regulation of blood/brain barrier permeability" EXACT [] +synonym: "downregulation of BBB permeability" EXACT [] +synonym: "downregulation of blood-brain barrier permeability" EXACT [] +synonym: "downregulation of blood/brain barrier permeability" EXACT [] +synonym: "inhibition of maintenance of permeability of BBB" NARROW [GOC:TermGenie] +synonym: "inhibition of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie] +synonym: "negative regulation of BBB permeability" EXACT [] +synonym: "negative regulation of blood/brain barrier permeability" EXACT [] +is_a: GO:0043116 ! negative regulation of vascular permeability +is_a: GO:1905603 ! regulation of blood-brain barrier permeability + +[Term] +id: GO:1905605 +name: positive regulation of blood-brain barrier permeability +namespace: biological_process +def: "Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain." [GO_REF:0000058, GOC:als, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:22524708, PMID:30280653] +synonym: "activation of maintenance of permeability of BBB" NARROW [GOC:TermGenie] +synonym: "activation of maintenance of permeability of blood-brain barrier" NARROW [GOC:TermGenie] +synonym: "positive regulation of BBB permeability" EXACT [] +synonym: "positive regulation of blood/brain barrier permeability" EXACT [] +synonym: "up-regulation of BBB permeability" EXACT [] +synonym: "up-regulation of blood-brain barrier permeability" EXACT [] +synonym: "up-regulation of blood/brain barrier permeability" EXACT [] +synonym: "upregulation of BBB permeability" EXACT [] +synonym: "upregulation of blood-brain barrier permeability" EXACT [] +synonym: "upregulation of blood/brain barrier permeability" EXACT [] +is_a: GO:0043117 ! positive regulation of vascular permeability +is_a: GO:1905603 ! regulation of blood-brain barrier permeability + +[Term] +id: GO:1905606 +name: regulation of presynapse assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] +subset: goslim_synapse +synonym: "regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +is_a: GO:0051963 ! regulation of synapse assembly +is_a: GO:0099174 ! regulation of presynapse organization +relationship: regulates GO:0099054 ! presynapse assembly + +[Term] +id: GO:1905607 +name: negative regulation of presynapse assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] +synonym: "down regulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "inhibition of presynapse assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of presynapse biogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of presynaptic terminal assembly" NARROW [GOC:TermGenie] +synonym: "negative regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +is_a: GO:0051964 ! negative regulation of synapse assembly +is_a: GO:1905606 ! regulation of presynapse assembly +relationship: negatively_regulates GO:0099054 ! presynapse assembly + +[Term] +id: GO:1905608 +name: positive regulation of presynapse assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of presynapse assembly." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483] +synonym: "activation of presynapse assembly" NARROW [GOC:TermGenie] +synonym: "activation of presynapse biogenesis" NARROW [GOC:TermGenie] +synonym: "activation of presynaptic terminal assembly" NARROW [GOC:TermGenie] +synonym: "positive regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of presynapse assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of presynapse biogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of presynaptic terminal assembly" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905606 ! regulation of presynapse assembly +relationship: positively_regulates GO:0099054 ! presynapse assembly + +[Term] +id: GO:1905609 +name: positive regulation of smooth muscle cell-matrix adhesion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GO_REF:0000058, GOC:TermGenie, PMID:14970114] +synonym: "activation of smooth muscle cell-matrix adhesion" NARROW [GOC:TermGenie] +synonym: "up regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle cell-matrix adhesion" EXACT [GOC:TermGenie] +is_a: GO:0001954 ! positive regulation of cell-matrix adhesion +is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion +relationship: positively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion + +[Term] +id: GO:1905610 +name: regulation of mRNA cap binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +is_a: GO:1902415 ! regulation of mRNA binding + +[Term] +id: GO:1905611 +name: negative regulation of mRNA cap binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +synonym: "down regulation of mRNA cap binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of mRNA cap binding" EXACT [GOC:TermGenie] +synonym: "downregulation of mRNA cap binding" EXACT [GOC:TermGenie] +synonym: "inhibition of mRNA cap binding" NARROW [GOC:TermGenie] +is_a: GO:1904572 ! negative regulation of mRNA binding +is_a: GO:1905610 ! regulation of mRNA cap binding + +[Term] +id: GO:1905612 +name: positive regulation of mRNA cap binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA cap binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +synonym: "activation of mRNA cap binding" NARROW [GOC:TermGenie] +synonym: "up regulation of mRNA cap binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of mRNA cap binding" EXACT [GOC:TermGenie] +synonym: "upregulation of mRNA cap binding" EXACT [GOC:TermGenie] +is_a: GO:1902416 ! positive regulation of mRNA binding +is_a: GO:1905610 ! regulation of mRNA cap binding + +[Term] +id: GO:1905613 +name: regulation of developmental vegetative growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] +is_a: GO:0048638 ! regulation of developmental growth +relationship: regulates GO:0080186 ! developmental vegetative growth + +[Term] +id: GO:1905614 +name: negative regulation of developmental vegetative growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] +synonym: "down regulation of developmental vegetative growth" EXACT [GOC:TermGenie] +synonym: "down-regulation of developmental vegetative growth" EXACT [GOC:TermGenie] +synonym: "downregulation of developmental vegetative growth" EXACT [GOC:TermGenie] +synonym: "inhibition of developmental vegetative growth" NARROW [GOC:TermGenie] +is_a: GO:0048640 ! negative regulation of developmental growth +is_a: GO:1905613 ! regulation of developmental vegetative growth +relationship: negatively_regulates GO:0080186 ! developmental vegetative growth + +[Term] +id: GO:1905615 +name: positive regulation of developmental vegetative growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of developmental vegetative growth." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] +synonym: "activation of developmental vegetative growth" NARROW [GOC:TermGenie] +synonym: "up regulation of developmental vegetative growth" EXACT [GOC:TermGenie] +synonym: "up-regulation of developmental vegetative growth" EXACT [GOC:TermGenie] +synonym: "upregulation of developmental vegetative growth" EXACT [GOC:TermGenie] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:1905613 ! regulation of developmental vegetative growth +relationship: positively_regulates GO:0080186 ! developmental vegetative growth + +[Term] +id: GO:1905616 +name: regulation of miRNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +synonym: "regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "regulation of miRNA mediated inhibition of translation" EXACT [] +synonym: "regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +is_a: GO:0006417 ! regulation of translation +is_a: GO:0060964 ! regulation of gene silencing by miRNA +relationship: regulates GO:0035278 ! miRNA-mediated gene silencing by inhibition of translation + +[Term] +id: GO:1905617 +name: negative regulation of miRNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +synonym: "down regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "down regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "down regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "down regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "down regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "down-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "down-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "down-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "down-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "downregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "downregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "downregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "downregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "inhibition of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "inhibition of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "inhibition of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "inhibition of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie] +synonym: "inhibition of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "inhibition of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie] +synonym: "inhibition of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "inhibition of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie] +synonym: "negative regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "negative regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "negative regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "negative regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "negative regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "negative regulation of miRNA mediated inhibition of translation" EXACT [] +synonym: "negative regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "negative regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:0060965 ! negative regulation of gene silencing by miRNA +is_a: GO:1905616 ! regulation of miRNA-mediated gene silencing by inhibition of translation +relationship: negatively_regulates GO:0035278 ! miRNA-mediated gene silencing by inhibition of translation + +[Term] +id: GO:1905618 +name: positive regulation of miRNA-mediated gene silencing by inhibition of translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of miRNA-mediated gene silencing by inhibition of translation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23409027] +synonym: "activation of down regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "activation of down-regulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "activation of downregulation of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "activation of gene silencing by miRNA, negative regulation of translation" NARROW [GOC:TermGenie] +synonym: "activation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "activation of miRNA mediated inhibition of translation" NARROW [GOC:TermGenie] +synonym: "activation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "activation of negative regulation of translation involved in gene silencing by microRNA" NARROW [GOC:TermGenie] +synonym: "positive regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "positive regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "positive regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "positive regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "positive regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "positive regulation of miRNA mediated inhibition of translation" EXACT [] +synonym: "positive regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "positive regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "up regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "up regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "up regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "up-regulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "up-regulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "up-regulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "up-regulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of down regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of down-regulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of downregulation of translation involved in gene silencing by miRNA" EXACT [GOC:TermGenie] +synonym: "upregulation of gene silencing by miRNA, negative regulation of translation" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibition of translation involved in gene silencing by miRNA" NARROW [GOC:TermGenie] +synonym: "upregulation of miRNA mediated inhibition of translation" EXACT [GOC:TermGenie] +synonym: "upregulation of miRNA-mediated gene silencing, negative regulation of translation" RELATED [GOC:TermGenie] +synonym: "upregulation of negative regulation of translation involved in gene silencing by microRNA" EXACT [GOC:TermGenie] +is_a: GO:1905616 ! regulation of miRNA-mediated gene silencing by inhibition of translation +is_a: GO:2000637 ! positive regulation of gene silencing by miRNA +relationship: positively_regulates GO:0035278 ! miRNA-mediated gene silencing by inhibition of translation + +[Term] +id: GO:1905619 +name: regulation of alpha-(1->3)-fucosyltransferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] +synonym: "regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1905620 +name: negative regulation of alpha-(1->3)-fucosyltransferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] +synonym: "down regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0009892 ! negative regulation of metabolic process +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1905619 ! regulation of alpha-(1->3)-fucosyltransferase activity + +[Term] +id: GO:1905621 +name: positive regulation of alpha-(1->3)-fucosyltransferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity." [GO_REF:0000059, GOC:TermGenie, PMID:15364955] +synonym: "activation of alpha(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of alpha-(1,3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of alpha-(1->3)-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of alpha-1,3-fucosyltransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-(1,3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-(1->3)-fucosyltransferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of alpha-1,3-fucosyltransferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1905619 ! regulation of alpha-(1->3)-fucosyltransferase activity + +[Term] +id: GO:1905622 +name: negative regulation of leaf development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] +synonym: "down regulation of leaf development" EXACT [GOC:TermGenie] +synonym: "down-regulation of leaf development" EXACT [GOC:TermGenie] +synonym: "downregulation of leaf development" EXACT [GOC:TermGenie] +synonym: "inhibition of leaf development" NARROW [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000024 ! regulation of leaf development +relationship: negatively_regulates GO:0048366 ! leaf development + +[Term] +id: GO:1905623 +name: positive regulation of leaf development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leaf development." [GO_REF:0000058, GOC:TermGenie, PMID:11606552] +synonym: "activation of leaf development" NARROW [GOC:TermGenie] +synonym: "up regulation of leaf development" EXACT [GOC:TermGenie] +synonym: "up-regulation of leaf development" EXACT [GOC:TermGenie] +synonym: "upregulation of leaf development" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000024 ! regulation of leaf development +relationship: positively_regulates GO:0048366 ! leaf development + +[Term] +id: GO:1905624 +name: regulation of L-methionine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1905544 ! L-methionine import across plasma membrane + +[Term] +id: GO:1905625 +name: negative regulation of L-methionine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane +relationship: negatively_regulates GO:1905544 ! L-methionine import across plasma membrane + +[Term] +id: GO:1905626 +name: positive regulation of L-methionine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-methionine import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:17556368] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:1905624 ! regulation of L-methionine import across plasma membrane +relationship: positively_regulates GO:1905544 ! L-methionine import across plasma membrane + +[Term] +id: GO:1905627 +name: regulation of serotonin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] +synonym: "regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "regulation of serotonin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0042427 ! serotonin biosynthetic process + +[Term] +id: GO:1905628 +name: negative regulation of serotonin biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] +synonym: "down regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "down regulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "downregulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of serotonin anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of serotonin biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of serotonin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of serotonin formation" NARROW [GOC:TermGenie] +synonym: "inhibition of serotonin synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of serotonin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:1905627 ! regulation of serotonin biosynthetic process +relationship: negatively_regulates GO:0042427 ! serotonin biosynthetic process + +[Term] +id: GO:1905629 +name: positive regulation of serotonin biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process." [GO_REF:0000058, GOC:pad, GOC:PARL, GOC:TermGenie, PMID:25642596] +synonym: "activation of serotonin anabolism" NARROW [GOC:TermGenie] +synonym: "activation of serotonin biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of serotonin biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of serotonin formation" NARROW [GOC:TermGenie] +synonym: "activation of serotonin synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "up regulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of serotonin synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of serotonin anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of serotonin biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of serotonin biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of serotonin formation" EXACT [GOC:TermGenie] +synonym: "upregulation of serotonin synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:1905627 ! regulation of serotonin biosynthetic process +relationship: positively_regulates GO:0042427 ! serotonin biosynthetic process + +[Term] +id: GO:1905630 +name: response to glyceraldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826] +is_a: GO:0034284 ! response to monosaccharide + +[Term] +id: GO:1905631 +name: cellular response to glyceraldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyceraldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:11377826] +is_a: GO:0071326 ! cellular response to monosaccharide stimulus +is_a: GO:1905630 ! response to glyceraldehyde + +[Term] +id: GO:1905632 +name: protein localization to euchromatin +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] +synonym: "protein localisation in euchromatin" EXACT [GOC:TermGenie] +synonym: "protein localisation to euchromatin" EXACT [GOC:TermGenie] +synonym: "protein localization in euchromatin" EXACT [GOC:TermGenie] +is_a: GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:1905633 +name: establishment of protein localization to euchromatin +namespace: biological_process +def: "The directed movement of a protein to a specific location in an euchromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20889714] +synonym: "establishment of protein localisation in euchromatin" EXACT [GOC:TermGenie] +synonym: "establishment of protein localisation to euchromatin" EXACT [GOC:TermGenie] +synonym: "establishment of protein localization in euchromatin" EXACT [GOC:TermGenie] +is_a: GO:0071169 ! establishment of protein localization to chromatin +is_a: GO:1905632 ! protein localization to euchromatin + +[Term] +id: GO:1905634 +name: regulation of protein localization to chromatin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to chromatin." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] +synonym: "regulation of protein localisation to chromatin" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0071168 ! protein localization to chromatin + +[Term] +id: GO:1905635 +name: FACT complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a FACT complex." [GO_REF:0000079, GOC:TermGenie, PMID:20889714] +synonym: "Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "FACT complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905636 +name: positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23675531] +synonym: "activation of RNA polymerase II regulatory region sequence-specific DNA binding" NARROW [GOC:TermGenie] +synonym: "up regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding" EXACT [GOC:TermGenie] +is_a: GO:1903025 ! regulation of RNA polymerase II regulatory region sequence-specific DNA binding +is_a: GO:2000679 ! positive regulation of transcription regulatory region DNA binding + +[Term] +id: GO:1905637 +name: regulation of mitochondrial mRNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] +is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process +is_a: GO:0061013 ! regulation of mRNA catabolic process +relationship: regulates GO:0000958 ! mitochondrial mRNA catabolic process + +[Term] +id: GO:1905638 +name: negative regulation of mitochondrial mRNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] +synonym: "down regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "inhibition of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie] +is_a: GO:0000961 ! negative regulation of mitochondrial RNA catabolic process +is_a: GO:1902373 ! negative regulation of mRNA catabolic process +is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process +relationship: negatively_regulates GO:0000958 ! mitochondrial mRNA catabolic process + +[Term] +id: GO:1905639 +name: positive regulation of mitochondrial mRNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitochondrial mRNA catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:27122350] +synonym: "activation of mitochondrial mRNA catabolic process" NARROW [GOC:TermGenie] +synonym: "up regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of mitochondrial mRNA catabolic process" EXACT [GOC:TermGenie] +is_a: GO:0000962 ! positive regulation of mitochondrial RNA catabolic process +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:1905637 ! regulation of mitochondrial mRNA catabolic process +relationship: positively_regulates GO:0000958 ! mitochondrial mRNA catabolic process + +[Term] +id: GO:1905640 +name: response to acetaldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866] +is_a: GO:0010033 ! response to organic substance +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905641 +name: cellular response to acetaldehyde +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetaldehyde stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:27687866] +is_a: GO:0110096 ! cellular response to aldehyde +is_a: GO:1905640 ! response to acetaldehyde + +[Term] +id: GO:1905642 +name: negative regulation of DNA methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] +synonym: "down regulation of DNA methylation" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA methylation" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA methylation" EXACT [GOC:TermGenie] +synonym: "inhibition of DNA methylation" NARROW [GOC:TermGenie] +is_a: GO:0044030 ! regulation of DNA methylation +is_a: GO:0051053 ! negative regulation of DNA metabolic process +relationship: negatively_regulates GO:0006306 ! DNA methylation + +[Term] +id: GO:1905643 +name: positive regulation of DNA methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA methylation." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:27336847] +synonym: "activation of DNA methylation" NARROW [GOC:TermGenie] +synonym: "up regulation of DNA methylation" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA methylation" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA methylation" EXACT [GOC:TermGenie] +is_a: GO:0044030 ! regulation of DNA methylation +is_a: GO:0051054 ! positive regulation of DNA metabolic process +relationship: positively_regulates GO:0006306 ! DNA methylation + +[Term] +id: GO:1905644 +name: regulation of FACT complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] +synonym: "regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of FACT complex formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1905635 ! FACT complex assembly + +[Term] +id: GO:1905645 +name: negative regulation of FACT complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] +synonym: "down regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "inhibition of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of FACT complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of FACT complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of FACT complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1905644 ! regulation of FACT complex assembly +relationship: negatively_regulates GO:1905635 ! FACT complex assembly + +[Term] +id: GO:1905646 +name: positive regulation of FACT complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of FACT complex assembly." [GO_REF:0000058, GOC:TermGenie, PMID:20889714] +synonym: "activation of Facilitates chromatin transcription complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Facilitates chromatin transcription complex formation" NARROW [GOC:TermGenie] +synonym: "activation of FACT complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of FACT complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of FACT complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of Facilitates chromatin transcription complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Facilitates chromatin transcription complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of FACT complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of FACT complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1905644 ! regulation of FACT complex assembly +relationship: positively_regulates GO:1905635 ! FACT complex assembly + +[Term] +id: GO:1905647 +name: proline import across plasma membrane +namespace: biological_process +alt_id: GO:1902825 +def: "The directed movement of proline from outside of a cell into the cytoplasmic compartment." [GO_REF:0000075, GOC:TermGenie, PMID:24344203] +synonym: "proline import into cell" EXACT [] +is_a: GO:0035524 ! proline transmembrane transport +is_a: GO:0089718 ! amino acid import across plasma membrane + +[Term] +id: GO:1905648 +name: regulation of shell calcification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] +is_a: GO:0070167 ! regulation of biomineral tissue development +relationship: regulates GO:0031215 ! shell calcification + +[Term] +id: GO:1905649 +name: negative regulation of shell calcification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] +synonym: "down regulation of shell calcification" EXACT [GOC:TermGenie] +synonym: "down-regulation of shell calcification" EXACT [GOC:TermGenie] +synonym: "downregulation of shell calcification" EXACT [GOC:TermGenie] +synonym: "inhibition of shell calcification" NARROW [GOC:TermGenie] +is_a: GO:0070168 ! negative regulation of biomineral tissue development +is_a: GO:1905648 ! regulation of shell calcification +relationship: negatively_regulates GO:0031215 ! shell calcification + +[Term] +id: GO:1905650 +name: positive regulation of shell calcification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of shell calcification." [GO_REF:0000058, GOC:TermGenie, PMID:14648763] +synonym: "activation of shell calcification" NARROW [GOC:TermGenie] +synonym: "up regulation of shell calcification" EXACT [GOC:TermGenie] +synonym: "up-regulation of shell calcification" EXACT [GOC:TermGenie] +synonym: "upregulation of shell calcification" EXACT [GOC:TermGenie] +is_a: GO:0070169 ! positive regulation of biomineral tissue development +is_a: GO:1905648 ! regulation of shell calcification +relationship: positively_regulates GO:0031215 ! shell calcification + +[Term] +id: GO:1905651 +name: regulation of artery morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +synonym: "regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "regulation of arteriogenesis" EXACT [GOC:TermGenie] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0048844 ! artery morphogenesis + +[Term] +id: GO:1905652 +name: negative regulation of artery morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +synonym: "down regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of artery morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of artery morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of artery morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of arterial morphogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of arteriogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of artery morphogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of arteriogenesis" EXACT [GOC:TermGenie] +is_a: GO:1905651 ! regulation of artery morphogenesis +is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis +relationship: negatively_regulates GO:0048844 ! artery morphogenesis + +[Term] +id: GO:1905653 +name: positive regulation of artery morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of artery morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +synonym: "activation of arterial morphogenesis" NARROW [GOC:TermGenie] +synonym: "activation of arteriogenesis" NARROW [GOC:TermGenie] +synonym: "activation of artery morphogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of artery morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of artery morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arterial morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of arteriogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of artery morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1905651 ! regulation of artery morphogenesis +relationship: positively_regulates GO:0048844 ! artery morphogenesis + +[Term] +id: GO:1905654 +name: regulation of artery smooth muscle contraction +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +is_a: GO:0003056 ! regulation of vascular associated smooth muscle contraction +relationship: regulates GO:0014824 ! artery smooth muscle contraction + +[Term] +id: GO:1905655 +name: negative regulation of artery smooth muscle contraction +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +synonym: "down regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "down-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "downregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "inhibition of artery smooth muscle contraction" NARROW [GOC:TermGenie] +is_a: GO:1904694 ! negative regulation of vascular associated smooth muscle contraction +is_a: GO:1905654 ! regulation of artery smooth muscle contraction +relationship: negatively_regulates GO:0014824 ! artery smooth muscle contraction + +[Term] +id: GO:1905656 +name: positive regulation of artery smooth muscle contraction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of artery smooth muscle contraction." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:27389411] +synonym: "activation of artery smooth muscle contraction" NARROW [GOC:TermGenie] +synonym: "up regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "up-regulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +synonym: "upregulation of artery smooth muscle contraction" EXACT [GOC:TermGenie] +is_a: GO:1904695 ! positive regulation of vascular associated smooth muscle contraction +is_a: GO:1905654 ! regulation of artery smooth muscle contraction +relationship: positively_regulates GO:0014824 ! artery smooth muscle contraction + +[Term] +id: GO:1905660 +name: mitotic checkpoint complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a mitotic checkpoint complex." [GO_REF:0000079, GOC:TermGenie, PMID:26882497] +synonym: "MCC assembly" EXACT [GOC:TermGenie] +synonym: "MCC formation" EXACT [GOC:TermGenie] +synonym: "mitotic checkpoint complex formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905661 +name: regulation of telomerase RNA reverse transcriptase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] +synonym: "regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +is_a: GO:0051972 ! regulation of telomerase activity + +[Term] +id: GO:1905662 +name: negative regulation of telomerase RNA reverse transcriptase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] +synonym: "down regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "downregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "inhibition of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of telomerase, catalyst" NARROW [GOC:TermGenie] +synonym: "negative regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +is_a: GO:0051974 ! negative regulation of telomerase activity +is_a: GO:1905661 ! regulation of telomerase RNA reverse transcriptase activity + +[Term] +id: GO:1905663 +name: positive regulation of telomerase RNA reverse transcriptase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomerase RNA reverse transcriptase activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:22633954] +synonym: "activation of telomerase RNA reverse transcriptase activity" NARROW [GOC:TermGenie] +synonym: "activation of telomerase, catalyst" NARROW [GOC:TermGenie] +synonym: "positive regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "up regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomerase, catalyst" EXACT [GOC:TermGenie] +synonym: "upregulation of telomerase RNA reverse transcriptase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of telomerase, catalyst" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1905661 ! regulation of telomerase RNA reverse transcriptase activity + +[Term] +id: GO:1905664 +name: regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). +is_a: GO:0010522 ! regulation of calcium ion transport into cytosol +is_a: GO:0090279 ! regulation of calcium ion import +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +relationship: regulates GO:0098703 ! calcium ion import across plasma membrane + +[Term] +id: GO:1905665 +name: positive regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). +synonym: "activation of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:0010524 ! positive regulation of calcium ion transport into cytosol +is_a: GO:0090280 ! positive regulation of calcium ion import +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane +relationship: positively_regulates GO:0098703 ! calcium ion import across plasma membrane + +[Term] +id: GO:1905666 +name: regulation of protein localization to endosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] +synonym: "regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in endosome" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0036010 ! protein localization to endosome + +[Term] +id: GO:1905667 +name: negative regulation of protein localization to endosome +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] +synonym: "down regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to endosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to endosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to endosome" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in endosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in endosome" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to endosome" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in endosome" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905666 ! regulation of protein localization to endosome +relationship: negatively_regulates GO:0036010 ! protein localization to endosome + +[Term] +id: GO:1905668 +name: positive regulation of protein localization to endosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to endosome." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:22732145] +synonym: "activation of protein localisation in endosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in endosome" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to endosome" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in endosome" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to endosome" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905666 ! regulation of protein localization to endosome +relationship: positively_regulates GO:0036010 ! protein localization to endosome + +[Term] +id: GO:1905669 +name: TORC1 complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] +synonym: "dTOR/dRaptor complex assembly" NARROW [GOC:TermGenie] +synonym: "dTOR/dRaptor complex formation" NARROW [GOC:TermGenie] +synonym: "dTORC1 assembly" NARROW [GOC:TermGenie] +synonym: "dTORC1 formation" NARROW [GOC:TermGenie] +synonym: "mTORC1 assembly" NARROW [GOC:TermGenie] +synonym: "mTORC1 formation" NARROW [GOC:TermGenie] +synonym: "nutrient sensitive complex assembly" EXACT [GOC:TermGenie] +synonym: "nutrient sensitive complex formation" EXACT [GOC:TermGenie] +synonym: "rapamycin and nutrient-sensitive TOR complex assembly" EXACT [GOC:TermGenie] +synonym: "rapamycin and nutrient-sensitive TOR complex formation" EXACT [GOC:TermGenie] +synonym: "TOR complex 1 assembly" EXACT [GOC:TermGenie] +synonym: "TOR complex 1 formation" EXACT [GOC:TermGenie] +synonym: "TORC 1 complex assembly" EXACT [GOC:TermGenie] +synonym: "TORC 1 complex formation" EXACT [GOC:TermGenie] +synonym: "TORC1 assembly" EXACT [GOC:TermGenie] +synonym: "TORC1 complex formation" EXACT [GOC:TermGenie] +synonym: "TORC1 formation" EXACT [GOC:TermGenie] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1905670 +name: TORC2 complex disassembly +namespace: biological_process +def: "The disaggregation of a TORC2 complex into its constituent components." [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] +synonym: "mTORC2 disassembly" NARROW [GOC:TermGenie] +synonym: "rapamycin and nutrient-insensitive TOR complex disassembly" EXACT [GOC:TermGenie] +synonym: "TOR complex 2 disassembly" EXACT [GOC:TermGenie] +synonym: "TORC 2 complex disassembly" EXACT [GOC:TermGenie] +synonym: "TORC2 disassembly" EXACT [GOC:TermGenie] +is_a: GO:0032984 ! protein-containing complex disassembly + +[Term] +id: GO:1905671 +name: regulation of lysosome organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] +synonym: "regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0044088 ! regulation of vacuole organization +relationship: regulates GO:0007040 ! lysosome organization + +[Term] +id: GO:1905672 +name: negative regulation of lysosome organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] +synonym: "down regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "down regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "downregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of lysosome organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosome organization" NARROW [GOC:TermGenie] +synonym: "inhibition of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1905671 ! regulation of lysosome organization +relationship: negatively_regulates GO:0007040 ! lysosome organization + +[Term] +id: GO:1905673 +name: positive regulation of lysosome organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lysosome organization." [GO_REF:0000058, GOC:TermGenie, PMID:25561470] +synonym: "activation of lysosome organisation" NARROW [GOC:TermGenie] +synonym: "activation of lysosome organization" NARROW [GOC:TermGenie] +synonym: "activation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "positive regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "up regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "up-regulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "upregulation of lysosome organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosome organization" EXACT [GOC:TermGenie] +synonym: "upregulation of lysosome organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0044090 ! positive regulation of vacuole organization +is_a: GO:1905671 ! regulation of lysosome organization +relationship: positively_regulates GO:0007040 ! lysosome organization + +[Term] +id: GO:1905674 +name: regulation of adaptive immune memory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] +is_a: GO:0002819 ! regulation of adaptive immune response +relationship: regulates GO:0090716 ! adaptive immune memory response + +[Term] +id: GO:1905675 +name: negative regulation of adaptive immune memory response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] +synonym: "down regulation of adaptive immune memory response" EXACT [GOC:TermGenie] +synonym: "down-regulation of adaptive immune memory response" EXACT [GOC:TermGenie] +synonym: "downregulation of adaptive immune memory response" EXACT [GOC:TermGenie] +synonym: "inhibition of adaptive immune memory response" NARROW [GOC:TermGenie] +is_a: GO:0002820 ! negative regulation of adaptive immune response +is_a: GO:1905674 ! regulation of adaptive immune memory response +relationship: negatively_regulates GO:0090716 ! adaptive immune memory response + +[Term] +id: GO:1905676 +name: positive regulation of adaptive immune memory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adaptive immune memory response." [GO_REF:0000058, GOC:TermGenie, PMID:26831526] +synonym: "activation of adaptive immune memory response" NARROW [GOC:TermGenie] +synonym: "up regulation of adaptive immune memory response" EXACT [GOC:TermGenie] +synonym: "up-regulation of adaptive immune memory response" EXACT [GOC:TermGenie] +synonym: "upregulation of adaptive immune memory response" EXACT [GOC:TermGenie] +is_a: GO:0002821 ! positive regulation of adaptive immune response +is_a: GO:1905674 ! regulation of adaptive immune memory response +relationship: positively_regulates GO:0090716 ! adaptive immune memory response + +[Term] +id: GO:1905677 +name: regulation of adaptive immune effector response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] +is_a: GO:0002819 ! regulation of adaptive immune response +relationship: regulates GO:0090718 ! adaptive immune effector response + +[Term] +id: GO:1905678 +name: negative regulation of adaptive immune effector response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] +synonym: "down regulation of adaptive immune effector response" EXACT [GOC:TermGenie] +synonym: "down-regulation of adaptive immune effector response" EXACT [GOC:TermGenie] +synonym: "downregulation of adaptive immune effector response" EXACT [GOC:TermGenie] +synonym: "inhibition of adaptive immune effector response" NARROW [GOC:TermGenie] +is_a: GO:0002820 ! negative regulation of adaptive immune response +is_a: GO:1905677 ! regulation of adaptive immune effector response +relationship: negatively_regulates GO:0090718 ! adaptive immune effector response + +[Term] +id: GO:1905679 +name: positive regulation of adaptive immune effector response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of adaptive immune effector response." [GO_REF:0000058, GOC:TermGenie, ISBN:9781405196833] +synonym: "activation of adaptive immune effector response" NARROW [GOC:TermGenie] +synonym: "up regulation of adaptive immune effector response" EXACT [GOC:TermGenie] +synonym: "up-regulation of adaptive immune effector response" EXACT [GOC:TermGenie] +synonym: "upregulation of adaptive immune effector response" EXACT [GOC:TermGenie] +is_a: GO:0002821 ! positive regulation of adaptive immune response +is_a: GO:1905677 ! regulation of adaptive immune effector response +relationship: positively_regulates GO:0090718 ! adaptive immune effector response + +[Term] +id: GO:1905680 +name: regulation of innate immunity memory response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] +is_a: GO:0045088 ! regulation of innate immune response +relationship: regulates GO:0090714 ! innate immunity memory response + +[Term] +id: GO:1905681 +name: negative regulation of innate immunity memory response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] +synonym: "down regulation of innate immunity memory response" EXACT [GOC:TermGenie] +synonym: "down-regulation of innate immunity memory response" EXACT [GOC:TermGenie] +synonym: "downregulation of innate immunity memory response" EXACT [GOC:TermGenie] +synonym: "inhibition of innate immunity memory response" NARROW [GOC:TermGenie] +is_a: GO:0045824 ! negative regulation of innate immune response +is_a: GO:1905680 ! regulation of innate immunity memory response +relationship: negatively_regulates GO:0090714 ! innate immunity memory response + +[Term] +id: GO:1905682 +name: positive regulation of innate immunity memory response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of innate immunity memory response." [GO_REF:0000058, GOC:TermGenie] +synonym: "activation of innate immunity memory response" NARROW [GOC:TermGenie] +synonym: "up regulation of innate immunity memory response" EXACT [GOC:TermGenie] +synonym: "up-regulation of innate immunity memory response" EXACT [GOC:TermGenie] +synonym: "upregulation of innate immunity memory response" EXACT [GOC:TermGenie] +is_a: GO:0045089 ! positive regulation of innate immune response +is_a: GO:1905680 ! regulation of innate immunity memory response +relationship: positively_regulates GO:0090714 ! innate immunity memory response + +[Term] +id: GO:1905683 +name: peroxisome disassembly +namespace: biological_process +def: "The disaggregation of a peroxisome into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] +synonym: "peroxisomal disassembly" RELATED [GOC:TermGenie] +is_a: GO:0007031 ! peroxisome organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1905684 +name: regulation of plasma membrane repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] +is_a: GO:1903729 ! regulation of plasma membrane organization +relationship: regulates GO:0001778 ! plasma membrane repair + +[Term] +id: GO:1905685 +name: negative regulation of plasma membrane repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] +synonym: "down regulation of plasma membrane repair" EXACT [GOC:TermGenie] +synonym: "down-regulation of plasma membrane repair" EXACT [GOC:TermGenie] +synonym: "downregulation of plasma membrane repair" EXACT [GOC:TermGenie] +synonym: "inhibition of plasma membrane repair" NARROW [GOC:TermGenie] +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:0061045 ! negative regulation of wound healing +is_a: GO:1905684 ! regulation of plasma membrane repair +relationship: negatively_regulates GO:0001778 ! plasma membrane repair + +[Term] +id: GO:1905686 +name: positive regulation of plasma membrane repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plasma membrane repair." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:22940583] +synonym: "activation of plasma membrane repair" NARROW [GOC:TermGenie] +synonym: "up regulation of plasma membrane repair" EXACT [GOC:TermGenie] +synonym: "up-regulation of plasma membrane repair" EXACT [GOC:TermGenie] +synonym: "upregulation of plasma membrane repair" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905684 ! regulation of plasma membrane repair +relationship: positively_regulates GO:0001778 ! plasma membrane repair + +[Term] +id: GO:1905687 +name: regulation of diacylglycerol kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] +synonym: "regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0043549 ! regulation of kinase activity + +[Term] +id: GO:1905688 +name: negative regulation of diacylglycerol kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] +synonym: "down regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "down regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "down regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "down-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "downregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "downregulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie] +synonym: "inhibition of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DG kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DGK activity" NARROW [GOC:TermGenie] +synonym: "inhibition of diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of diglyceride kinase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "negative regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "negative regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0033673 ! negative regulation of kinase activity +is_a: GO:1905687 ! regulation of diacylglycerol kinase activity + +[Term] +id: GO:1905689 +name: positive regulation of diacylglycerol kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of diacylglycerol kinase activity." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23091060] +synonym: "activation of 1,2-diacylglycerol kinase (phosphorylating)" NARROW [GOC:TermGenie] +synonym: "activation of 1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of arachidonoyl-specific diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "activation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of DG kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of DGK activity" NARROW [GOC:TermGenie] +synonym: "activation of diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of diglyceride kinase activity" NARROW [GOC:TermGenie] +synonym: "activation of sn-1,2-diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "positive regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "up regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "up-regulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of 1,2-diacylglycerol kinase (phosphorylating)" EXACT [GOC:TermGenie] +synonym: "upregulation of 1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of arachidonoyl-specific diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of ATP:diacylglycerol phosphotransferase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of CTP:diacylglycerol kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of DG kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DGK activity" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of diacylglycerol:ATP kinase activity" NARROW [GOC:TermGenie] +synonym: "upregulation of diglyceride kinase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of sn-1,2-diacylglycerol kinase activity" EXACT [GOC:TermGenie] +is_a: GO:0033674 ! positive regulation of kinase activity +is_a: GO:1905687 ! regulation of diacylglycerol kinase activity + +[Term] +id: GO:1905690 +name: nucleus disassembly +namespace: biological_process +def: "The disaggregation of a nucleus into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] +synonym: "cell nucleus disassembly" EXACT [GOC:TermGenie] +is_a: GO:0006997 ! nucleus organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1905691 +name: lipid droplet disassembly +namespace: biological_process +def: "The disaggregation of a lipid particle into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] +synonym: "adiposome disassembly" EXACT [GOC:TermGenie] +synonym: "lipid body disassembly" EXACT [GOC:TermGenie] +synonym: "lipid droplet reserve breakdown" EXACT [PMID:30003614] +synonym: "lipid particle disassembly" EXACT [GOC:TermGenie] +is_a: GO:0034389 ! lipid droplet organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1905692 +name: endoplasmic reticulum disassembly +namespace: biological_process +def: "The disaggregation of an endoplasmic reticulum into its constituent components." [GO_REF:0000079, GOC:autophagy, GOC:pr, GOC:TermGenie] +synonym: "ER disassembly" EXACT [GOC:TermGenie] +is_a: GO:0007029 ! endoplasmic reticulum organization +is_a: GO:1903008 ! organelle disassembly + +[Term] +id: GO:1905693 +name: regulation of phosphatidic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] +synonym: "regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +relationship: regulates GO:0006654 ! phosphatidic acid biosynthetic process + +[Term] +id: GO:1905694 +name: negative regulation of phosphatidic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] +synonym: "down regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid formation" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidic acid synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process +relationship: negatively_regulates GO:0006654 ! phosphatidic acid biosynthetic process + +[Term] +id: GO:1905695 +name: positive regulation of phosphatidic acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidic acid biosynthetic process." [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:23767959] +synonym: "activation of phosphatidic acid anabolism" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidic acid biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidic acid biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidic acid formation" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidic acid synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid formation" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidic acid synthesis" EXACT [GOC:TermGenie] +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +is_a: GO:1905693 ! regulation of phosphatidic acid biosynthetic process +relationship: positively_regulates GO:0006654 ! phosphatidic acid biosynthetic process + +[Term] +id: GO:1905696 +name: regulation of polysome binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "regulation of polyribosome binding" EXACT [GOC:TermGenie] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1905697 +name: negative regulation of polysome binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "down regulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "down regulation of polysome binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of polysome binding" EXACT [GOC:TermGenie] +synonym: "downregulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "downregulation of polysome binding" EXACT [GOC:TermGenie] +synonym: "inhibition of polyribosome binding" NARROW [GOC:TermGenie] +synonym: "inhibition of polysome binding" NARROW [GOC:TermGenie] +synonym: "negative regulation of polyribosome binding" EXACT [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1905696 ! regulation of polysome binding + +[Term] +id: GO:1905698 +name: positive regulation of polysome binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of polysome binding." [GO_REF:0000059, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:18426977] +synonym: "activation of polyribosome binding" NARROW [GOC:TermGenie] +synonym: "activation of polysome binding" NARROW [GOC:TermGenie] +synonym: "positive regulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "up regulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "up regulation of polysome binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of polysome binding" EXACT [GOC:TermGenie] +synonym: "upregulation of polyribosome binding" EXACT [GOC:TermGenie] +synonym: "upregulation of polysome binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1905696 ! regulation of polysome binding + +[Term] +id: GO:1905699 +name: regulation of xenobiotic detoxification by transmembrane export across the plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509] +synonym: "regulation of drug transmembrane export" NARROW [] +synonym: "regulation of xenobiotic transmembrane export" NARROW [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:2001023 ! regulation of response to drug +relationship: regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane + +[Term] +id: GO:1905700 +name: negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509] +synonym: "down regulation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "down-regulation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "downregulation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "inhibition of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "negative regulation of drug transmembrane export" NARROW [] +synonym: "negative regulation of xenobiotic transmembrane export" NARROW [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane +is_a: GO:2001024 ! negative regulation of response to drug +relationship: negatively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane + +[Term] +id: GO:1905701 +name: positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical." [GO_REF:0000058, GOC:krc, GOC:TermGenie, PMID:15198509] +synonym: "activation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "positive regulation of drug transmembrane export" NARROW [] +synonym: "positive regulation of xenobiotic transmembrane export" NARROW [] +synonym: "up regulation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "up-regulation of drug transmembrane export" NARROW [GOC:TermGenie] +synonym: "upregulation of drug transmembrane export" NARROW [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905699 ! regulation of xenobiotic detoxification by transmembrane export across the plasma membrane +relationship: positively_regulates GO:1990961 ! xenobiotic detoxification by transmembrane export across the plasma membrane + +[Term] +id: GO:1905702 +name: regulation of inhibitory synapse assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051963 ! regulation of synapse assembly +relationship: regulates GO:1904862 ! inhibitory synapse assembly + +[Term] +id: GO:1905703 +name: negative regulation of inhibitory synapse assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "down regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "inhibition of inhibitory synapse assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of inhibitory synapse formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051964 ! negative regulation of synapse assembly +is_a: GO:1905702 ! regulation of inhibitory synapse assembly +relationship: negatively_regulates GO:1904862 ! inhibitory synapse assembly + +[Term] +id: GO:1905704 +name: positive regulation of inhibitory synapse assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inhibitory synapse assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "activation of inhibitory synapse assembly" NARROW [GOC:TermGenie] +synonym: "activation of inhibitory synapse formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibitory synapse assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of inhibitory synapse formation" EXACT [GOC:TermGenie] +is_a: GO:0051965 ! positive regulation of synapse assembly +is_a: GO:1905702 ! regulation of inhibitory synapse assembly +relationship: positively_regulates GO:1904862 ! inhibitory synapse assembly + +[Term] +id: GO:1905705 +name: cellular response to paclitaxel +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paclitaxel stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:18472094] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901555 ! response to paclitaxel + +[Term] +id: GO:1905706 +name: regulation of mitochondrial ATP synthesis coupled proton transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:2001169 ! regulation of ATP biosynthetic process +relationship: regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport + +[Term] +id: GO:1905707 +name: negative regulation of mitochondrial ATP synthesis coupled proton transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled proton transport." [GO_REF:0000058, GOC:TermGenie, PMID:12809520, PMID:15294286] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905706 ! regulation of mitochondrial ATP synthesis coupled proton transport +is_a: GO:2001170 ! negative regulation of ATP biosynthetic process +relationship: negatively_regulates GO:0042776 ! mitochondrial ATP synthesis coupled proton transport + +[Term] +id: GO:1905708 +name: regulation of cell morphogenesis involved in conjugation with cellular fusion +namespace: biological_process +def: "Any process that modulates the location, frequency, rate or extent of cell morphogenesis involved in conjugation with cellular fusion." [GO_REF:0000058, GOC:TermGenie, PMID:23200991] +synonym: "regulation of shmoo orientation" NARROW [GOC:TermGenie] +synonym: "regulation of shmooing" NARROW [GOC:TermGenie] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion + +[Term] +id: GO:1905709 +name: negative regulation of membrane permeability +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] +is_a: GO:0090559 ! regulation of membrane permeability + +[Term] +id: GO:1905710 +name: positive regulation of membrane permeability +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane." [PMID:27482894] +is_a: GO:0090559 ! regulation of membrane permeability + +[Term] +id: GO:1905711 +name: response to phosphatidylethanolamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995] +synonym: "response to PE" EXACT [] +synonym: "response to phosphatidyl(amino)ethanols" EXACT [] +synonym: "response to phosphatidylethanolamines" EXACT [] +synonym: "response to PtdEtn" EXACT [] +is_a: GO:0033993 ! response to lipid +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905712 +name: cellular response to phosphatidylethanolamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phosphatidylethanolamine stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:1657995] +synonym: "cellular response to PE" EXACT [] +synonym: "cellular response to phosphatidyl(amino)ethanols" EXACT [] +synonym: "cellular response to phosphatidylethanolamines" EXACT [] +synonym: "cellular response to PtdEtn" EXACT [] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905711 ! response to phosphatidylethanolamine + +[Term] +id: GO:1905713 +name: obsolete mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: biological_process +def: "OBSOLETE. Any mitochondrial calcium uptake that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium ion transmembrane import into mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] +synonym: "mitochondrial calcium uptake involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905714 +name: obsolete mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium ion concentration +namespace: biological_process +def: "OBSOLETE. Any mitochondrial calcium release that is involved in regulation of presynaptic cytosolic calcium ion concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium ion concentration" EXACT [GOC:TermGenie] +synonym: "calcium ion transmembrane export from mitochondrion involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] +synonym: "mitochondrial calcium release involved in regulation of presynaptic cytosolic calcium levels" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905715 +name: regulation of cornification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] +is_a: GO:0043067 ! regulation of programmed cell death +relationship: regulates GO:0070268 ! cornification + +[Term] +id: GO:1905716 +name: negative regulation of cornification +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] +synonym: "down regulation of cornification" EXACT [GOC:TermGenie] +synonym: "down-regulation of cornification" EXACT [GOC:TermGenie] +synonym: "downregulation of cornification" EXACT [GOC:TermGenie] +synonym: "inhibition of cornification" NARROW [GOC:TermGenie] +is_a: GO:0043069 ! negative regulation of programmed cell death +is_a: GO:1905715 ! regulation of cornification +relationship: negatively_regulates GO:0070268 ! cornification + +[Term] +id: GO:1905717 +name: positive regulation of cornification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cornification." [GO_REF:0000058, GOC:TermGenie, PMID:26014679] +synonym: "activation of cornification" NARROW [GOC:TermGenie] +synonym: "up regulation of cornification" EXACT [GOC:TermGenie] +synonym: "up-regulation of cornification" EXACT [GOC:TermGenie] +synonym: "upregulation of cornification" EXACT [GOC:TermGenie] +is_a: GO:0043068 ! positive regulation of programmed cell death +is_a: GO:1905715 ! regulation of cornification +relationship: positively_regulates GO:0070268 ! cornification + +[Term] +id: GO:1905718 +name: obsolete mitotic spindle astral microtubule end +namespace: cellular_component +def: "OBSOLETE. Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "mitotic spindle astral microtubule tip" EXACT [] +is_obsolete: true + +[Term] +id: GO:1905719 +name: protein localization to perinuclear region of cytoplasm +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the perinuclear region of the cytoplasm." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] +synonym: "protein localisation in perinuclear region of cytoplasm" EXACT [GOC:TermGenie] +synonym: "protein localisation to perinuclear region of cytoplasm" EXACT [GOC:TermGenie] +synonym: "protein localization in perinuclear region of cytoplasm" EXACT [GOC:TermGenie] +synonym: "protein localization to perinuclear cytoplasm" EXACT [] +is_a: GO:0008104 ! protein localization + +[Term] +id: GO:1905720 +name: cytoplasmic microtubule bundle +namespace: cellular_component +def: "Any microtubule bundle that is part of a cytoplasm." [GO_REF:0000064, GOC:TermGenie, PMID:11007487, PMID:26124291] +synonym: "microtubule bundle of cytoplasm" EXACT [GOC:TermGenie] +synonym: "microtubule fascicle of cytoplasm" EXACT [GOC:TermGenie] +is_a: GO:0097427 ! microtubule bundle +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1905721 +name: mitotic spindle astral microtubule end +namespace: cellular_component +def: "Any microtubule end that is part of a mitotic spindle astral microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] +synonym: "mitotic spindle astral microtubule tip" EXACT [] +is_a: GO:1990752 ! microtubule end +relationship: part_of GO:0061673 ! mitotic spindle astral microtubule + +[Term] +id: GO:1905722 +name: regulation of trypanothione biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] +synonym: "regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0019342 ! trypanothione biosynthetic process + +[Term] +id: GO:1905723 +name: negative regulation of trypanothione biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] +synonym: "down regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "down regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "downregulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of trypanothione anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of trypanothione biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of trypanothione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of trypanothione formation" NARROW [GOC:TermGenie] +synonym: "inhibition of trypanothione synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:1905722 ! regulation of trypanothione biosynthetic process +relationship: negatively_regulates GO:0019342 ! trypanothione biosynthetic process + +[Term] +id: GO:1905724 +name: positive regulation of trypanothione biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of trypanothione biosynthetic process." [GO_REF:0000058, GOC:TermGenie, PMID:18949025] +synonym: "activation of trypanothione anabolism" NARROW [GOC:TermGenie] +synonym: "activation of trypanothione biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of trypanothione biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of trypanothione formation" NARROW [GOC:TermGenie] +synonym: "activation of trypanothione synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "up regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of trypanothione synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of trypanothione anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of trypanothione biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of trypanothione biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of trypanothione formation" EXACT [GOC:TermGenie] +synonym: "upregulation of trypanothione synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:0051176 ! positive regulation of sulfur metabolic process +is_a: GO:1905722 ! regulation of trypanothione biosynthetic process +relationship: positively_regulates GO:0019342 ! trypanothione biosynthetic process + +[Term] +id: GO:1905725 +name: protein localization to microtubule end +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at a microtubule end." [GO_REF:0000087, GOC:TermGenie, PMID:12034771] +synonym: "protein localisation to microtubule end" EXACT [GOC:TermGenie] +is_a: GO:0035372 ! protein localization to microtubule + +[Term] +id: GO:1905735 +name: regulation of L-proline import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +is_a: GO:0070881 ! regulation of proline transport +is_a: GO:1902834 ! regulation of proline import across plasma membrane +is_a: GO:1903959 ! regulation of anion transmembrane transport +is_a: GO:1904062 ! regulation of cation transmembrane transport +relationship: regulates GO:1904271 ! L-proline import across plasma membrane + +[Term] +id: GO:1905736 +name: negative regulation of L-proline import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +is_a: GO:1902835 ! negative regulation of proline import across plasma membrane +is_a: GO:1903960 ! negative regulation of anion transmembrane transport +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:1905735 ! regulation of L-proline import across plasma membrane +relationship: negatively_regulates GO:1904271 ! L-proline import across plasma membrane + +[Term] +id: GO:1905737 +name: positive regulation of L-proline import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of L-proline import across plasma membrane." [GO_REF:0000058, GOC:TermGenie, PMID:24344203] +is_a: GO:1902836 ! positive regulation of proline import across plasma membrane +is_a: GO:1903961 ! positive regulation of anion transmembrane transport +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:1905735 ! regulation of L-proline import across plasma membrane +relationship: positively_regulates GO:1904271 ! L-proline import across plasma membrane + +[Term] +id: GO:1905741 +name: calcium export from the mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration +namespace: biological_process +def: "Any mitochondrial calcium release that is involved in positive regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] +synonym: "calcium ion transmembrane export from mitochondrion involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie] +synonym: "mitochondrial calcium release involved in positive regulation of presynaptic cytosolic calcium concentration" EXACT [] +is_a: GO:0099093 ! calcium export from the mitochondrion +is_a: GO:0099533 ! positive regulation of presynaptic cytosolic calcium concentration + +[Term] +id: GO:1905742 +name: Ras guanyl-nucleotide exchange factor complex +namespace: cellular_component +def: "A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity." [GO_REF:0000088, GOC:rjd, GOC:TermGenie, PMID:20493808] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1905743 +name: calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration +namespace: biological_process +def: "Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration." [GO_REF:0000060, GOC:TermGenie, PMID:26644474] +subset: goslim_synapse +synonym: "calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [GOC:TermGenie] +synonym: "mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration" EXACT [] +is_a: GO:0036444 ! calcium import into the mitochondrion +is_a: GO:0051649 ! establishment of localization in cell +relationship: part_of GO:0099113 ! negative regulation of presynaptic cytosolic calcium concentration + +[Term] +id: GO:1905744 +name: regulation of mRNA cis splicing, via spliceosome +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] +synonym: "regulation of nuclear mRNA cis splicing, via spliceosome" EXACT [GOC:TermGenie] +synonym: "regulation of nuclear mRNA cis splicing, via U2-type spliceosome" NARROW [GOC:TermGenie] +synonym: "regulation of splicing" BROAD [GOC:TermGenie] +is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome +relationship: regulates GO:0045292 ! mRNA cis splicing, via spliceosome + +[Term] +id: GO:1905745 +name: negative regulation of mRNA cis splicing, via spliceosome +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] +is_a: GO:0048025 ! negative regulation of mRNA splicing, via spliceosome +is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome +relationship: negatively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome + +[Term] +id: GO:1905746 +name: positive regulation of mRNA cis splicing, via spliceosome +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mRNA cis splicing, via spliceosome." [GO_REF:0000058, GOC:TermGenie, PMID:2880558] +is_a: GO:0048026 ! positive regulation of mRNA splicing, via spliceosome +is_a: GO:1905744 ! regulation of mRNA cis splicing, via spliceosome +relationship: positively_regulates GO:0045292 ! mRNA cis splicing, via spliceosome + +[Term] +id: GO:1905747 +name: negative regulation of saliva secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion." [GO_REF:0000058, GOC:TermGenie, PMID:23419067] +synonym: "down regulation of saliva secretion" EXACT [GOC:TermGenie] +synonym: "down regulation of salivation" EXACT [GOC:TermGenie] +synonym: "down-regulation of saliva secretion" EXACT [GOC:TermGenie] +synonym: "down-regulation of salivation" EXACT [GOC:TermGenie] +synonym: "downregulation of saliva secretion" EXACT [GOC:TermGenie] +synonym: "downregulation of salivation" EXACT [GOC:TermGenie] +synonym: "inhibition of saliva secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of salivation" NARROW [GOC:TermGenie] +synonym: "negative regulation of salivation" EXACT [GOC:TermGenie] +is_a: GO:0046877 ! regulation of saliva secretion +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060457 ! negative regulation of digestive system process +relationship: negatively_regulates GO:0046541 ! saliva secretion + +[Term] +id: GO:1905748 +name: hard palate morphogenesis +namespace: biological_process +def: "The developmental process by which a hard palate is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:23419067] +synonym: "palatum durum morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:1905749 +name: regulation of endosome to plasma membrane protein transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:1903076 ! regulation of protein localization to plasma membrane +is_a: GO:2001135 ! regulation of endocytic recycling +relationship: regulates GO:0099638 ! endosome to plasma membrane protein transport + +[Term] +id: GO:1905750 +name: negative regulation of endosome to plasma membrane protein transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] +synonym: "down regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +synonym: "downregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +synonym: "inhibition of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie] +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1903077 ! negative regulation of protein localization to plasma membrane +is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport +is_a: GO:2001136 ! negative regulation of endocytic recycling +relationship: negatively_regulates GO:0099638 ! endosome to plasma membrane protein transport + +[Term] +id: GO:1905751 +name: positive regulation of endosome to plasma membrane protein transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport." [GO_REF:0000058, GOC:TermGenie, PMID:22869721] +synonym: "activation of endosome to plasma membrane protein transport" NARROW [GOC:TermGenie] +synonym: "up regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +synonym: "upregulation of endosome to plasma membrane protein transport" EXACT [GOC:TermGenie] +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane +is_a: GO:1905749 ! regulation of endosome to plasma membrane protein transport +is_a: GO:2001137 ! positive regulation of endocytic recycling +relationship: positively_regulates GO:0099638 ! endosome to plasma membrane protein transport + +[Term] +id: GO:1905752 +name: regulation of argininosuccinate synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403] +synonym: "regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] +synonym: "regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] +is_a: GO:0051340 ! regulation of ligase activity + +[Term] +id: GO:1905753 +name: positive regulation of argininosuccinate synthase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity." [GO_REF:0000059, GOC:TermGenie, PMID:19491403] +synonym: "activation of arginine succinate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of argininosuccinate synthase activity" NARROW [GOC:TermGenie] +synonym: "activation of argininosuccinate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of argininosuccinic acid synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of arginosuccinate synthetase activity" NARROW [GOC:TermGenie] +synonym: "activation of citrulline--aspartate ligase activity" NARROW [GOC:TermGenie] +synonym: "activation of L-citrulline:L-aspartate ligase (AMP-forming)" NARROW [GOC:TermGenie] +synonym: "positive regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] +synonym: "positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] +synonym: "upregulation of arginine succinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of argininosuccinate synthase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of argininosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of argininosuccinic acid synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of arginosuccinate synthetase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of citrulline--aspartate ligase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [GOC:TermGenie] +is_a: GO:0051351 ! positive regulation of ligase activity +is_a: GO:1905752 ! regulation of argininosuccinate synthase activity + +[Term] +id: GO:1905754 +name: ascospore-type prospore nucleus +namespace: cellular_component +def: "Any nucleus that is part of a ascospore-type prospore." [GO_REF:0000064, GOC:TermGenie, PMID:26942678] +synonym: "cell nucleus of ascospore-type prospore" EXACT [GOC:TermGenie] +synonym: "nucleus of ascospore-type prospore" EXACT [GOC:TermGenie] +is_a: GO:0005634 ! nucleus +relationship: part_of GO:0042764 ! ascospore-type prospore + +[Term] +id: GO:1905755 +name: protein localization to cytoplasmic microtubule +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." [GO_REF:0000087, GOC:TermGenie, PMID:15177031] +synonym: "protein localisation to cytoplasmic microtubule" EXACT [GOC:TermGenie] +is_a: GO:0035372 ! protein localization to microtubule + +[Term] +id: GO:1905756 +name: regulation of primary cell septum biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] +is_a: GO:0140279 ! regulation of mitotic division septum assembly +relationship: regulates GO:0031671 ! primary cell septum biogenesis + +[Term] +id: GO:1905757 +name: negative regulation of primary cell septum biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] +is_a: GO:0140280 ! negative regulation of mitotic division septum assembly +is_a: GO:1905756 ! regulation of primary cell septum biogenesis +relationship: negatively_regulates GO:0031671 ! primary cell septum biogenesis + +[Term] +id: GO:1905758 +name: positive regulation of primary cell septum biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:27898700] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process +is_a: GO:1905756 ! regulation of primary cell septum biogenesis +relationship: positively_regulates GO:0031671 ! primary cell septum biogenesis + +[Term] +id: GO:1905759 +name: post-anaphase array microtubule +namespace: cellular_component +def: "Any microtubule that is part of a post-anaphase microtubule array." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] +synonym: "microtubule of PAA" EXACT [GOC:TermGenie] +synonym: "microtubule of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "microtubuli of PAA" EXACT [GOC:TermGenie] +synonym: "microtubuli of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "microtubulus of PAA" EXACT [GOC:TermGenie] +synonym: "microtubulus of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "neurotubule of PAA" NARROW [GOC:TermGenie] +synonym: "neurotubule of post-anaphase array" NARROW [GOC:TermGenie] +synonym: "neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie] +is_a: GO:0005874 ! microtubule +relationship: part_of GO:1990295 ! post-anaphase microtubule array + +[Term] +id: GO:1905760 +name: post-anaphase array microtubule end +namespace: cellular_component +def: "Any microtubule end that is part of a post-anaphase array microtubule." [GO_REF:0000064, GOC:TermGenie, PMID:11007487] +synonym: "microtubule end of microtubule of PAA" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubule of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubule of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubuli of PAA" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubuli of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubuli of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubulus of PAA" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubulus of post-anaphase array" EXACT [GOC:TermGenie] +synonym: "microtubule end of microtubulus of post-anaphase microtubule array" EXACT [GOC:TermGenie] +synonym: "microtubule end of neurotubule of PAA" NARROW [GOC:TermGenie] +synonym: "microtubule end of neurotubule of post-anaphase array" NARROW [GOC:TermGenie] +synonym: "microtubule end of neurotubule of post-anaphase microtubule array" NARROW [GOC:TermGenie] +synonym: "microtubule end of post-anaphase array microtubule" EXACT [GOC:TermGenie] +is_a: GO:1990752 ! microtubule end +relationship: part_of GO:1905759 ! post-anaphase array microtubule + +[Term] +id: GO:1905761 +name: SCF ubiquitin ligase complex binding +namespace: molecular_function +def: "Binding to a SCF ubiquitin ligase complex." [GOC:dph, GOC:ha, GOC:TermGenie, PMID:19723762] +synonym: "CDL1 complex binding" EXACT [GOC:TermGenie] +synonym: "CRL1 complex binding" EXACT [GOC:TermGenie] +synonym: "Cul1-RING ubiquitin ligase complex binding" EXACT [GOC:TermGenie] +synonym: "cullin-RING ligase 1 binding" EXACT [GOC:TermGenie] +synonym: "SCF complex binding" EXACT [GOC:TermGenie] +synonym: "SCF complex substrate recognition subunit binding" NARROW [GOC:TermGenie] +synonym: "Skp1/Cul1/F-box protein complex binding" EXACT [GOC:TermGenie] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1905762 +name: CCR4-NOT complex binding +namespace: molecular_function +def: "Binding to a CCR4-NOT complex." [GOC:TermGenie, PMID:26942678] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1905763 +name: MTREC complex binding +namespace: molecular_function +def: "Binding to a MTREC complex." [GOC:TermGenie, PMID:26942678] +synonym: "Mtl1-Red1 core complex binding" EXACT [GOC:TermGenie] +synonym: "NURS complex binding" EXACT [] +synonym: "PAXT complex binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1905764 +name: regulation of protection from non-homologous end joining at telomere +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] +synonym: "regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +is_a: GO:1904353 ! regulation of telomere capping +is_a: GO:1904505 ! regulation of telomere maintenance in response to DNA damage +relationship: regulates GO:0031848 ! protection from non-homologous end joining at telomere + +[Term] +id: GO:1905765 +name: negative regulation of protection from non-homologous end joining at telomere +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] +synonym: "down regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "down regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +synonym: "down-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "down-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +synonym: "downregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "downregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +synonym: "inhibition of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie] +synonym: "inhibition of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie] +synonym: "negative regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +is_a: GO:1904354 ! negative regulation of telomere capping +is_a: GO:1904506 ! negative regulation of telomere maintenance in response to DNA damage +is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere +relationship: negatively_regulates GO:0031848 ! protection from non-homologous end joining at telomere + +[Term] +id: GO:1905766 +name: positive regulation of protection from non-homologous end joining at telomere +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protection from non-homologous end joining at telomere." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:14690602] +synonym: "activation of protection from NHEJ-mediated telomere fusion" NARROW [GOC:TermGenie] +synonym: "activation of protection from non-homologous end joining at telomere" NARROW [GOC:TermGenie] +synonym: "positive regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "up regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +synonym: "up-regulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "up-regulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +synonym: "upregulation of protection from NHEJ-mediated telomere fusion" EXACT [GOC:TermGenie] +synonym: "upregulation of protection from non-homologous end joining at telomere" EXACT [GOC:TermGenie] +is_a: GO:1904507 ! positive regulation of telomere maintenance in response to DNA damage +is_a: GO:1905764 ! regulation of protection from non-homologous end joining at telomere +relationship: positively_regulates GO:0031848 ! protection from non-homologous end joining at telomere + +[Term] +id: GO:1905767 +name: regulation of double-stranded telomeric DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] +is_a: GO:1904742 ! regulation of telomeric DNA binding + +[Term] +id: GO:1905768 +name: negative regulation of double-stranded telomeric DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] +synonym: "down regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "downregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "inhibition of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie] +is_a: GO:1904743 ! negative regulation of telomeric DNA binding +is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding + +[Term] +id: GO:1905769 +name: positive regulation of double-stranded telomeric DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of double-stranded telomeric DNA binding." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:18812185] +synonym: "activation of double-stranded telomeric DNA binding" NARROW [GOC:TermGenie] +synonym: "up regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +synonym: "upregulation of double-stranded telomeric DNA binding" EXACT [GOC:TermGenie] +is_a: GO:1904744 ! positive regulation of telomeric DNA binding +is_a: GO:1905767 ! regulation of double-stranded telomeric DNA binding + +[Term] +id: GO:1905770 +name: regulation of mesodermal cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] +synonym: "regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0048333 ! mesodermal cell differentiation + +[Term] +id: GO:1905771 +name: negative regulation of mesodermal cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] +synonym: "down regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "down regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "downregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "inhibition of mesoderm cell differentiation" NARROW [GOC:TermGenie] +synonym: "inhibition of mesodermal cell differentiation" NARROW [GOC:TermGenie] +synonym: "negative regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1905770 ! regulation of mesodermal cell differentiation +relationship: negatively_regulates GO:0048333 ! mesodermal cell differentiation + +[Term] +id: GO:1905772 +name: positive regulation of mesodermal cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23765923] +synonym: "activation of mesoderm cell differentiation" NARROW [GOC:TermGenie] +synonym: "activation of mesodermal cell differentiation" NARROW [GOC:TermGenie] +synonym: "positive regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of mesoderm cell differentiation" EXACT [GOC:TermGenie] +synonym: "upregulation of mesodermal cell differentiation" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1905770 ! regulation of mesodermal cell differentiation +relationship: positively_regulates GO:0048333 ! mesodermal cell differentiation + +[Term] +id: GO:1905773 +name: 8-hydroxy-2'-deoxyguanosine DNA binding +namespace: molecular_function +def: "Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA." [GO_REF:0000067, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:19734539] +is_a: GO:0032357 ! oxidized purine DNA binding + +[Term] +id: GO:1905774 +name: regulation of DNA helicase activity +namespace: biological_process +alt_id: GO:1902449 +def: "Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] +synonym: "regulation of ATP-dependent DNA helicase activity" EXACT [] +is_a: GO:0051095 ! regulation of helicase activity +is_a: GO:1905462 ! regulation of DNA duplex unwinding + +[Term] +id: GO:1905775 +name: negative regulation of DNA helicase activity +namespace: biological_process +alt_id: GO:1902450 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] +synonym: "down regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "down regulation of DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie] +synonym: "inhibition of DNA helicase activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATP-dependent DNA helicase activity" EXACT [] +is_a: GO:0051097 ! negative regulation of helicase activity +is_a: GO:1905463 ! negative regulation of DNA duplex unwinding +is_a: GO:1905774 ! regulation of DNA helicase activity + +[Term] +id: GO:1905776 +name: positive regulation of DNA helicase activity +namespace: biological_process +alt_id: GO:1902451 +def: "Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity." [GOC:rb, GOC:TermGenie, PMID:13679365, PMID:19734539] +synonym: "activation of ATP-dependent DNA helicase activity" NARROW [GOC:TermGenie] +synonym: "activation of DNA helicase activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATP-dependent DNA helicase activity" EXACT [] +synonym: "up regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "up regulation of DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of ATP-dependent DNA helicase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of DNA helicase activity" EXACT [GOC:TermGenie] +is_a: GO:0051096 ! positive regulation of helicase activity +is_a: GO:1905464 ! positive regulation of DNA duplex unwinding +is_a: GO:1905774 ! regulation of DNA helicase activity + +[Term] +id: GO:1905777 +name: regulation of exonuclease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +synonym: "regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +is_a: GO:0032069 ! regulation of nuclease activity + +[Term] +id: GO:1905778 +name: negative regulation of exonuclease activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +synonym: "down regulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "down regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "down-regulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "downregulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "downregulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "inhibition of exonuclease activity" NARROW [GOC:TermGenie] +synonym: "inhibition of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "negative regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +is_a: GO:0032074 ! negative regulation of nuclease activity +is_a: GO:1905777 ! regulation of exonuclease activity + +[Term] +id: GO:1905779 +name: positive regulation of exonuclease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of exonuclease activity." [GO_REF:0000059, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +synonym: "activation of exonuclease activity" NARROW [GOC:TermGenie] +synonym: "activation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "positive regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "up regulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "up regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "up-regulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of exonuclease IX activity" NARROW [GOC:TermGenie] +synonym: "upregulation of exonuclease activity" EXACT [GOC:TermGenie] +synonym: "upregulation of exonuclease IX activity" NARROW [GOC:TermGenie] +is_a: GO:0032075 ! positive regulation of nuclease activity +is_a: GO:1905777 ! regulation of exonuclease activity + +[Term] +id: GO:1905780 +name: regulation of phosphatidylserine exposure on apoptotic cell surface +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] +synonym: "regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +is_a: GO:0061091 ! regulation of phospholipid translocation +is_a: GO:1903729 ! regulation of plasma membrane organization +relationship: regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface + +[Term] +id: GO:1905781 +name: negative regulation of phosphatidylserine exposure on apoptotic cell surface +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] +synonym: "down regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "down regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +synonym: "down-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "down-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +synonym: "downregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "downregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +synonym: "inhibition of externalization of phosphatidylserine" NARROW [GOC:TermGenie] +synonym: "inhibition of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie] +synonym: "negative regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +is_a: GO:0061093 ! negative regulation of phospholipid translocation +is_a: GO:1900118 ! negative regulation of execution phase of apoptosis +is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface +relationship: negatively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface + +[Term] +id: GO:1905782 +name: positive regulation of phosphatidylserine exposure on apoptotic cell surface +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:17401362] +synonym: "activation of externalization of phosphatidylserine" NARROW [GOC:TermGenie] +synonym: "activation of phosphatidylserine exposure on apoptotic cell surface" NARROW [GOC:TermGenie] +synonym: "positive regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "up regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "up regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +synonym: "up-regulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "up-regulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +synonym: "upregulation of externalization of phosphatidylserine" EXACT [GOC:TermGenie] +synonym: "upregulation of phosphatidylserine exposure on apoptotic cell surface" EXACT [GOC:TermGenie] +is_a: GO:0061092 ! positive regulation of phospholipid translocation +is_a: GO:1905780 ! regulation of phosphatidylserine exposure on apoptotic cell surface +relationship: positively_regulates GO:0070782 ! phosphatidylserine exposure on apoptotic cell surface + +[Term] +id: GO:1905783 +name: obsolete CENP-A containing nucleosome disassembly +namespace: biological_process +def: "OBSOLETE. The disaggregation of a CENP-A containing nucleosome into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27666591] +comment: This term was obsoleted because it did not describe a different process from that described by its parent. +synonym: "centromere specific nucleosome disassembly" RELATED [GOC:TermGenie] +synonym: "centromere-specific nucleosome disassembly" RELATED [GOC:TermGenie] +synonym: "centromeric nucleosome disassembly" RELATED [GOC:TermGenie] +is_obsolete: true +consider: GO:0006337 + +[Term] +id: GO:1905784 +name: regulation of anaphase-promoting complex-dependent catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] +is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process +relationship: regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process + +[Term] +id: GO:1905785 +name: negative regulation of anaphase-promoting complex-dependent catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] +is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process +relationship: negatively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process + +[Term] +id: GO:1905786 +name: positive regulation of anaphase-promoting complex-dependent catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:10921876] +is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process +is_a: GO:1905784 ! regulation of anaphase-promoting complex-dependent catabolic process +relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent catabolic process + +[Term] +id: GO:1905787 +name: regulation of detection of mechanical stimulus involved in sensory perception of touch +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0051931 ! regulation of sensory perception +relationship: regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch + +[Term] +id: GO:1905788 +name: negative regulation of detection of mechanical stimulus involved in sensory perception of touch +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "down regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "down regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "down regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "down regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "down-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "down-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "down-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "downregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "downregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "downregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] +synonym: "inhibition of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] +synonym: "inhibition of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] +synonym: "inhibition of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "negative regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "negative regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "negative regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +is_a: GO:0031645 ! negative regulation of nervous system process +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch +relationship: negatively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch + +[Term] +id: GO:1905789 +name: positive regulation of detection of mechanical stimulus involved in sensory perception of touch +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "activation of detection of mechanical stimulus involved in sensory perception of touch" NARROW [GOC:TermGenie] +synonym: "activation of perception of touch, detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "activation of perception of touch, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "activation of perception of touch, sensory transduction of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "activation of sensory detection of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] +synonym: "activation of sensory transduction of mechanical stimulus during perception of touch" NARROW [GOC:TermGenie] +synonym: "activation of tactition, sensory detection of mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "positive regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "positive regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "up regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "up regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "up regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "up-regulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "up-regulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "up-regulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of detection of mechanical stimulus involved in sensory perception of touch" EXACT [GOC:TermGenie] +synonym: "upregulation of perception of touch, detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of perception of touch, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of perception of touch, sensory transduction of mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of sensory detection of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "upregulation of sensory transduction of mechanical stimulus during perception of touch" EXACT [GOC:TermGenie] +synonym: "upregulation of tactition, sensory detection of mechanical stimulus" EXACT [GOC:TermGenie] +is_a: GO:0031646 ! positive regulation of nervous system process +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:1905787 ! regulation of detection of mechanical stimulus involved in sensory perception of touch +relationship: positively_regulates GO:0050976 ! detection of mechanical stimulus involved in sensory perception of touch + +[Term] +id: GO:1905790 +name: regulation of mechanosensory behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +is_a: GO:0032101 ! regulation of response to external stimulus +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0007638 ! mechanosensory behavior + +[Term] +id: GO:1905791 +name: negative regulation of mechanosensory behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "down regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "down regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "down-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "down-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "downregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "downregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "inhibition of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of mechanosensory behavior" NARROW [GOC:TermGenie] +synonym: "inhibition of mechanosensory behaviour" NARROW [GOC:TermGenie] +synonym: "negative regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "negative regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +is_a: GO:0032102 ! negative regulation of response to external stimulus +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:1905790 ! regulation of mechanosensory behavior +relationship: negatively_regulates GO:0007638 ! mechanosensory behavior + +[Term] +id: GO:1905792 +name: positive regulation of mechanosensory behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mechanosensory behavior." [GO_REF:0000058, GOC:TermGenie, PMID:8692859] +synonym: "activation of behavioral response to mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "activation of behavioural response to mechanical stimulus" NARROW [GOC:TermGenie] +synonym: "activation of mechanosensory behavior" NARROW [GOC:TermGenie] +synonym: "activation of mechanosensory behaviour" NARROW [GOC:TermGenie] +synonym: "positive regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "positive regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "up regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "up regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "up-regulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "up-regulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +synonym: "upregulation of behavioral response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of behavioural response to mechanical stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of mechanosensory behavior" EXACT [GOC:TermGenie] +synonym: "upregulation of mechanosensory behaviour" EXACT [GOC:TermGenie] +is_a: GO:0032103 ! positive regulation of response to external stimulus +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:1905790 ! regulation of mechanosensory behavior +relationship: positively_regulates GO:0007638 ! mechanosensory behavior + +[Term] +id: GO:1905793 +name: protein localization to pericentriolar material +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a pericentriolar material." [GO_REF:0000087, GOC:TermGenie, PMID:21694707, PMID:24385583] +synonym: "protein localisation in pericentriolar material" EXACT [GOC:TermGenie] +synonym: "protein localisation to pericentriolar material" EXACT [GOC:TermGenie] +synonym: "protein localization in pericentriolar material" EXACT [GOC:TermGenie] +is_a: GO:0071539 ! protein localization to centrosome + +[Term] +id: GO:1905794 +name: response to puromycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] +synonym: "response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] +is_a: GO:0014074 ! response to purine-containing compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905795 +name: cellular response to puromycin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a puromycin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:25736288] +synonym: "cellular response to 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine" EXACT [] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905794 ! response to puromycin + +[Term] +id: GO:1905796 +name: regulation of intraciliary anterograde transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0035720 ! intraciliary anterograde transport + +[Term] +id: GO:1905797 +name: negative regulation of intraciliary anterograde transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "down regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "down regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "downregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "downregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "inhibition of intraciliary anterograde transport" NARROW [GOC:TermGenie] +synonym: "inhibition of intraflagellar anterograde transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1905796 ! regulation of intraciliary anterograde transport +relationship: negatively_regulates GO:0035720 ! intraciliary anterograde transport + +[Term] +id: GO:1905798 +name: positive regulation of intraciliary anterograde transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "activation of intraciliary anterograde transport" NARROW [GOC:TermGenie] +synonym: "activation of intraflagellar anterograde transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "up regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "up regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +synonym: "upregulation of intraciliary anterograde transport" EXACT [GOC:TermGenie] +synonym: "upregulation of intraflagellar anterograde transport" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1905796 ! regulation of intraciliary anterograde transport +relationship: positively_regulates GO:0035720 ! intraciliary anterograde transport + +[Term] +id: GO:1905799 +name: regulation of intraciliary retrograde transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0035721 ! intraciliary retrograde transport + +[Term] +id: GO:1905800 +name: negative regulation of intraciliary retrograde transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "down regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "down regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "downregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "downregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "inhibition of intraciliary retrograde transport" NARROW [GOC:TermGenie] +synonym: "inhibition of intraflagellar retrograde transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:1905799 ! regulation of intraciliary retrograde transport +relationship: negatively_regulates GO:0035721 ! intraciliary retrograde transport + +[Term] +id: GO:1905801 +name: positive regulation of intraciliary retrograde transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intraciliary retrograde transport." [GO_REF:0000058, GOC:TermGenie, PMID:27930654] +synonym: "activation of intraciliary retrograde transport" NARROW [GOC:TermGenie] +synonym: "activation of intraflagellar retrograde transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "up regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "up regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +synonym: "upregulation of intraciliary retrograde transport" EXACT [GOC:TermGenie] +synonym: "upregulation of intraflagellar retrograde transport" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:1905799 ! regulation of intraciliary retrograde transport +relationship: positively_regulates GO:0035721 ! intraciliary retrograde transport + +[Term] +id: GO:1905802 +name: regulation of cellular response to manganese ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +synonym: "regulation of cellular response to manganese" EXACT [GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071287 ! cellular response to manganese ion + +[Term] +id: GO:1905803 +name: negative regulation of cellular response to manganese ion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +synonym: "down regulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to manganese" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to manganese ion" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to manganese" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905802 ! regulation of cellular response to manganese ion +relationship: negatively_regulates GO:0071287 ! cellular response to manganese ion + +[Term] +id: GO:1905804 +name: positive regulation of cellular response to manganese ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to manganese ion." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +synonym: "activation of cellular response to manganese" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to manganese ion" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to manganese" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to manganese ion" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905802 ! regulation of cellular response to manganese ion +relationship: positively_regulates GO:0071287 ! cellular response to manganese ion + +[Term] +id: GO:1905805 +name: excitatory synapse pruning +namespace: biological_process +def: "The disaggregation of an excitatory synapse into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:27779093] +synonym: "synapse clearance" BROAD [] +synonym: "synapse disassembly" BROAD [] +synonym: "synapse elimination" BROAD [] +synonym: "synapse removal" BROAD [] +is_a: GO:0098883 ! synapse pruning + +[Term] +id: GO:1905806 +name: regulation of synapse pruning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +subset: goslim_synapse +synonym: "regulation of synapse clearance" EXACT [] +synonym: "regulation of synapse disassembly" EXACT syngo_official_label [] +synonym: "regulation of synapse elimination" EXACT [] +synonym: "regulation of synapse removal" EXACT [] +is_a: GO:0050807 ! regulation of synapse organization +relationship: regulates GO:0098883 ! synapse pruning + +[Term] +id: GO:1905807 +name: negative regulation of synapse pruning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "down regulation of synapse disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of synapse disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of synapse disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of synapse disassembly" NARROW [GOC:TermGenie] +synonym: "regulation of synapse clearance" BROAD [] +synonym: "regulation of synapse disassembly" BROAD [] +synonym: "regulation of synapse elimination" BROAD [] +synonym: "regulation of synapse removal" BROAD [] +is_a: GO:1905806 ! regulation of synapse pruning +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0098883 ! synapse pruning + +[Term] +id: GO:1905808 +name: positive regulation of synapse pruning +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "activation of synapse disassembly" NARROW [GOC:TermGenie] +synonym: "regulation of synapse clearance" BROAD [] +synonym: "regulation of synapse disassembly" BROAD [] +synonym: "regulation of synapse elimination" BROAD [] +synonym: "regulation of synapse removal" BROAD [] +synonym: "up regulation of synapse disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of synapse disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of synapse disassembly" EXACT [GOC:TermGenie] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:1905806 ! regulation of synapse pruning +relationship: positively_regulates GO:0098883 ! synapse pruning + +[Term] +id: GO:1905809 +name: negative regulation of synapse organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "down regulation of synapse development" EXACT [GOC:TermGenie] +synonym: "down regulation of synapse morphogenesis" RELATED [GOC:TermGenie] +synonym: "down regulation of synapse organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of synapse organization" EXACT [GOC:TermGenie] +synonym: "down regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of synapse development" EXACT [GOC:TermGenie] +synonym: "down-regulation of synapse morphogenesis" RELATED [GOC:TermGenie] +synonym: "down-regulation of synapse organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of synapse organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of synapse development" EXACT [GOC:TermGenie] +synonym: "downregulation of synapse morphogenesis" RELATED [GOC:TermGenie] +synonym: "downregulation of synapse organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of synapse organization" EXACT [GOC:TermGenie] +synonym: "downregulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of synapse development" NARROW [GOC:TermGenie] +synonym: "inhibition of synapse morphogenesis" RELATED [GOC:TermGenie] +synonym: "inhibition of synapse organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of synapse organization" NARROW [GOC:TermGenie] +synonym: "inhibition of synapse organization and biogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of synapse development" EXACT [GOC:TermGenie] +synonym: "negative regulation of synapse morphogenesis" RELATED [GOC:TermGenie] +synonym: "negative regulation of synapse organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of synapse organization and biogenesis" RELATED [GOC:TermGenie] +is_a: GO:0050807 ! regulation of synapse organization +is_a: GO:0051129 ! negative regulation of cellular component organization +relationship: negatively_regulates GO:0050808 ! synapse organization + +[Term] +id: GO:1905810 +name: regulation of excitatory synapse pruning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "regulation of synapse clearance" BROAD [] +synonym: "regulation of synapse disassembly" BROAD [] +synonym: "regulation of synapse elimination" BROAD [] +synonym: "regulation of synapse removal" BROAD [] +is_a: GO:1905806 ! regulation of synapse pruning +relationship: regulates GO:1905805 ! excitatory synapse pruning + +[Term] +id: GO:1905811 +name: negative regulation of excitatory synapse pruning +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning." [GO_REF:0000058, GOC:TermGenie, PMID:27779093] +synonym: "down regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of excitatory synapse disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of excitatory synapse disassembly" NARROW [GOC:TermGenie] +synonym: "regulation of synapse clearance" BROAD [] +synonym: "regulation of synapse disassembly" BROAD [] +synonym: "regulation of synapse elimination" BROAD [] +synonym: "regulation of synapse removal" BROAD [] +is_a: GO:1905807 ! negative regulation of synapse pruning +is_a: GO:1905810 ! regulation of excitatory synapse pruning +relationship: negatively_regulates GO:1905805 ! excitatory synapse pruning + +[Term] +id: GO:1905812 +name: regulation of motor neuron axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0008045 ! motor neuron axon guidance + +[Term] +id: GO:1905813 +name: negative regulation of motor neuron axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "down regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "downregulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "inhibition of motoneuron axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of motor axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of motor axon pathfinding" NARROW [GOC:TermGenie] +synonym: "inhibition of motor neuron axon guidance" NARROW [GOC:TermGenie] +synonym: "negative regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "negative regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "negative regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +is_a: GO:1902668 ! negative regulation of axon guidance +is_a: GO:1905812 ! regulation of motor neuron axon guidance +relationship: negatively_regulates GO:0008045 ! motor neuron axon guidance + +[Term] +id: GO:1905814 +name: positive regulation of motor neuron axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of motor neuron axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "activation of motoneuron axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of motor axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of motor axon pathfinding" NARROW [GOC:TermGenie] +synonym: "activation of motor neuron axon guidance" NARROW [GOC:TermGenie] +synonym: "positive regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "positive regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "positive regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of motoneuron axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of motor axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of motor axon pathfinding" EXACT [GOC:TermGenie] +synonym: "upregulation of motor neuron axon guidance" EXACT [GOC:TermGenie] +is_a: GO:1902669 ! positive regulation of axon guidance +is_a: GO:1905812 ! regulation of motor neuron axon guidance +relationship: positively_regulates GO:0008045 ! motor neuron axon guidance + +[Term] +id: GO:1905815 +name: regulation of dorsal/ventral axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0033563 ! dorsal/ventral axon guidance + +[Term] +id: GO:1905816 +name: negative regulation of dorsal/ventral axon guidance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "down regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "down regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "down-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "down-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "downregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "downregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "inhibition of dorsal-ventral axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of dorsal/ventral axon guidance" NARROW [GOC:TermGenie] +synonym: "inhibition of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie] +synonym: "inhibition of dorsoventral axon guidance" NARROW [GOC:TermGenie] +synonym: "negative regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "negative regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "negative regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +is_a: GO:1902668 ! negative regulation of axon guidance +is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance +relationship: negatively_regulates GO:0033563 ! dorsal/ventral axon guidance + +[Term] +id: GO:1905817 +name: positive regulation of dorsal/ventral axon guidance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dorsal/ventral axon guidance." [GO_REF:0000058, GOC:TermGenie, PMID:18434533] +synonym: "activation of dorsal-ventral axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of dorsal/ventral axon guidance" NARROW [GOC:TermGenie] +synonym: "activation of dorsal/ventral axon pathfinding" NARROW [GOC:TermGenie] +synonym: "activation of dorsoventral axon guidance" NARROW [GOC:TermGenie] +synonym: "positive regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "positive regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "positive regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "up-regulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "up-regulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of dorsal-ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of dorsal/ventral axon guidance" EXACT [GOC:TermGenie] +synonym: "upregulation of dorsal/ventral axon pathfinding" EXACT [GOC:TermGenie] +synonym: "upregulation of dorsoventral axon guidance" EXACT [GOC:TermGenie] +is_a: GO:1902669 ! positive regulation of axon guidance +is_a: GO:1905815 ! regulation of dorsal/ventral axon guidance +relationship: positively_regulates GO:0033563 ! dorsal/ventral axon guidance + +[Term] +id: GO:1905818 +name: regulation of chromosome separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] +synonym: "regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "regulation of rDNA separation" NARROW [GOC:TermGenie] +is_a: GO:0010564 ! regulation of cell cycle process +is_a: GO:0051983 ! regulation of chromosome segregation +relationship: regulates GO:0051304 ! chromosome separation + +[Term] +id: GO:1905819 +name: negative regulation of chromosome separation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] +synonym: "down regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "down regulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "down regulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "down-regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "down-regulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "down-regulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "downregulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "downregulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "downregulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "inhibition of chromatid release" RELATED [GOC:TermGenie] +synonym: "inhibition of chromosome separation" NARROW [GOC:TermGenie] +synonym: "inhibition of rDNA separation" NARROW [GOC:TermGenie] +synonym: "negative regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "negative regulation of rDNA separation" NARROW [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0051985 ! negative regulation of chromosome segregation +is_a: GO:1905818 ! regulation of chromosome separation +relationship: negatively_regulates GO:0051304 ! chromosome separation + +[Term] +id: GO:1905820 +name: positive regulation of chromosome separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromosome separation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:21795393] +synonym: "activation of chromatid release" RELATED [GOC:TermGenie] +synonym: "activation of chromosome separation" NARROW [GOC:TermGenie] +synonym: "activation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "positive regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "positive regulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "up regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "up regulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "up regulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "up-regulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "up-regulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "up-regulation of rDNA separation" NARROW [GOC:TermGenie] +synonym: "upregulation of chromatid release" RELATED [GOC:TermGenie] +synonym: "upregulation of chromosome separation" EXACT [GOC:TermGenie] +synonym: "upregulation of rDNA separation" NARROW [GOC:TermGenie] +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:1905818 ! regulation of chromosome separation +relationship: positively_regulates GO:0051304 ! chromosome separation + +[Term] +id: GO:1905821 +name: positive regulation of chromosome condensation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromosome condensation." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17268547] +synonym: "activation of chromosome condensation" NARROW [GOC:TermGenie] +synonym: "activation of eukaryotic chromosome condensation" NARROW [GOC:TermGenie] +synonym: "activation of nuclear chromosome condensation" NARROW [GOC:TermGenie] +synonym: "positive regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "positive regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up regulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up-regulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up-regulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "up-regulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +synonym: "upregulation of chromosome condensation" EXACT [GOC:TermGenie] +synonym: "upregulation of eukaryotic chromosome condensation" EXACT [GOC:TermGenie] +synonym: "upregulation of nuclear chromosome condensation" EXACT [GOC:TermGenie] +is_a: GO:0060623 ! regulation of chromosome condensation +is_a: GO:2001252 ! positive regulation of chromosome organization +relationship: positively_regulates GO:0030261 ! chromosome condensation + +[Term] +id: GO:1905822 +name: regulation of mitotic sister chromatid arm separation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] +is_a: GO:0010965 ! regulation of mitotic sister chromatid separation +relationship: regulates GO:1990891 ! mitotic sister chromatid arm separation + +[Term] +id: GO:1905823 +name: negative regulation of mitotic sister chromatid arm separation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] +synonym: "down regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +synonym: "downregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +synonym: "inhibition of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie] +is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation +is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation +relationship: negatively_regulates GO:1990891 ! mitotic sister chromatid arm separation + +[Term] +id: GO:1905824 +name: positive regulation of mitotic sister chromatid arm separation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation." [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:18765790] +synonym: "activation of mitotic sister chromatid arm separation" NARROW [GOC:TermGenie] +synonym: "up regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +synonym: "upregulation of mitotic sister chromatid arm separation" EXACT [GOC:TermGenie] +is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation +is_a: GO:1905822 ! regulation of mitotic sister chromatid arm separation +relationship: positively_regulates GO:1990891 ! mitotic sister chromatid arm separation + +[Term] +id: GO:1905825 +name: regulation of selenocysteine metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] +synonym: "regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +relationship: regulates GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:1905826 +name: negative regulation of selenocysteine metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] +synonym: "down regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "inhibition of selenocysteine metabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of selenocysteine metabolism" NARROW [GOC:TermGenie] +synonym: "negative regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:1905825 ! regulation of selenocysteine metabolic process +relationship: negatively_regulates GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:1905827 +name: positive regulation of selenocysteine metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of selenocysteine metabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:19716792] +synonym: "activation of selenocysteine metabolic process" NARROW [GOC:TermGenie] +synonym: "activation of selenocysteine metabolism" NARROW [GOC:TermGenie] +synonym: "positive regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of selenocysteine metabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of selenocysteine metabolism" EXACT [GOC:TermGenie] +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:1905825 ! regulation of selenocysteine metabolic process +relationship: positively_regulates GO:0016259 ! selenocysteine metabolic process + +[Term] +id: GO:1905828 +name: regulation of prostaglandin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] +synonym: "regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009894 ! regulation of catabolic process +relationship: regulates GO:1905344 ! prostaglandin catabolic process + +[Term] +id: GO:1905829 +name: negative regulation of prostaglandin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] +synonym: "down regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "down regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "down regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "down-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "down-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "downregulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "downregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "downregulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "inhibition of prostaglandin breakdown" NARROW [GOC:TermGenie] +synonym: "inhibition of prostaglandin catabolic process" NARROW [GOC:TermGenie] +synonym: "inhibition of prostaglandin catabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of prostaglandin degradation" NARROW [GOC:TermGenie] +synonym: "negative regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "negative regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:1905828 ! regulation of prostaglandin catabolic process +relationship: negatively_regulates GO:1905344 ! prostaglandin catabolic process + +[Term] +id: GO:1905830 +name: positive regulation of prostaglandin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of prostaglandin catabolic process." [GO_REF:0000058, GOC:TermGenie, PMID:12432938] +synonym: "activation of prostaglandin breakdown" NARROW [GOC:TermGenie] +synonym: "activation of prostaglandin catabolic process" NARROW [GOC:TermGenie] +synonym: "activation of prostaglandin catabolism" NARROW [GOC:TermGenie] +synonym: "activation of prostaglandin degradation" NARROW [GOC:TermGenie] +synonym: "positive regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "positive regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "up regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "up regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "up regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "up-regulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "up-regulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of prostaglandin degradation" EXACT [GOC:TermGenie] +synonym: "upregulation of prostaglandin breakdown" EXACT [GOC:TermGenie] +synonym: "upregulation of prostaglandin catabolic process" EXACT [GOC:TermGenie] +synonym: "upregulation of prostaglandin catabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of prostaglandin degradation" EXACT [GOC:TermGenie] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:1905828 ! regulation of prostaglandin catabolic process +relationship: positively_regulates GO:1905344 ! prostaglandin catabolic process + +[Term] +id: GO:1905831 +name: negative regulation of spindle assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] +synonym: "down regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "down regulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "downregulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "inhibition of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of bipolar spindle formation" NARROW [GOC:TermGenie] +synonym: "inhibition of spindle assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of spindle biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of spindle formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of spindle formation" EXACT [GOC:TermGenie] +is_a: GO:0010948 ! negative regulation of cell cycle process +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:0090169 ! regulation of spindle assembly +is_a: GO:1902116 ! negative regulation of organelle assembly +relationship: negatively_regulates GO:0051225 ! spindle assembly + +[Term] +id: GO:1905832 +name: positive regulation of spindle assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of spindle assembly." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] +synonym: "activation of bipolar spindle biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of bipolar spindle formation" NARROW [GOC:TermGenie] +synonym: "activation of spindle assembly" NARROW [GOC:TermGenie] +synonym: "activation of spindle biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of spindle formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of spindle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of bipolar spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of bipolar spindle formation" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of spindle formation" EXACT [GOC:TermGenie] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:0090068 ! positive regulation of cell cycle process +is_a: GO:0090169 ! regulation of spindle assembly +is_a: GO:1902117 ! positive regulation of organelle assembly +relationship: positively_regulates GO:0051225 ! spindle assembly + +[Term] +id: GO:1905833 +name: negative regulation of microtubule nucleation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation." [GO_REF:0000058, GOC:TermGenie, PMID:27689799] +synonym: "down regulation of microtubule nucleation" EXACT [GOC:TermGenie] +synonym: "down-regulation of microtubule nucleation" EXACT [GOC:TermGenie] +synonym: "downregulation of microtubule nucleation" EXACT [GOC:TermGenie] +synonym: "inhibition of microtubule nucleation" NARROW [GOC:TermGenie] +is_a: GO:0010968 ! regulation of microtubule nucleation +is_a: GO:0031115 ! negative regulation of microtubule polymerization +relationship: negatively_regulates GO:0007020 ! microtubule nucleation + +[Term] +id: GO:1905834 +name: response to pyrimidine ribonucleotide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602] +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0046683 ! response to organophosphorus +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1905835 +name: cellular response to pyrimidine ribonucleotide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrimidine ribonucleotide stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:22065602] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:0071417 ! cellular response to organonitrogen compound +is_a: GO:1901701 ! cellular response to oxygen-containing compound +is_a: GO:1905834 ! response to pyrimidine ribonucleotide + +[Term] +id: GO:1905836 +name: response to triterpenoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994] +is_a: GO:0033993 ! response to lipid + +[Term] +id: GO:1905837 +name: cellular response to triterpenoid +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triterpenoid stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:28078994] +is_a: GO:0071396 ! cellular response to lipid +is_a: GO:1905836 ! response to triterpenoid + +[Term] +id: GO:1905838 +name: regulation of telomeric D-loop disassembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +is_a: GO:1904533 ! regulation of telomeric loop disassembly +relationship: regulates GO:0061820 ! telomeric D-loop disassembly + +[Term] +id: GO:1905839 +name: negative regulation of telomeric D-loop disassembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +synonym: "down regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of telomeric D-loop disassembly" NARROW [GOC:TermGenie] +is_a: GO:1904534 ! negative regulation of telomeric loop disassembly +is_a: GO:1905838 ! regulation of telomeric D-loop disassembly +relationship: negatively_regulates GO:0061820 ! telomeric D-loop disassembly + +[Term] +id: GO:1905840 +name: positive regulation of telomeric D-loop disassembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of telomeric D-loop disassembly." [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:15200954] +synonym: "activation of telomeric D-loop disassembly" NARROW [GOC:TermGenie] +synonym: "up regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of telomeric D-loop disassembly" EXACT [GOC:TermGenie] +is_a: GO:1904535 ! positive regulation of telomeric loop disassembly +is_a: GO:1905838 ! regulation of telomeric D-loop disassembly +relationship: positively_regulates GO:0061820 ! telomeric D-loop disassembly + +[Term] +id: GO:1905841 +name: response to oxidopamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] +is_a: GO:0071869 ! response to catecholamine + +[Term] +id: GO:1905842 +name: cellular response to oxidopamine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidopamine stimulus." [GO_REF:0000071, GOC:rz, GOC:TermGenie, PMID:23721876] +is_a: GO:0071870 ! cellular response to catecholamine stimulus +is_a: GO:1905841 ! response to oxidopamine + +[Term] +id: GO:1905843 +name: regulation of cellular response to gamma radiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] +synonym: "regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:2001228 ! regulation of response to gamma radiation +relationship: regulates GO:0071480 ! cellular response to gamma radiation + +[Term] +id: GO:1905844 +name: negative regulation of cellular response to gamma radiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] +synonym: "down regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "down regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "down-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "downregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular response to gamma radiation" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "inhibition of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "negative regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "negative regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1905843 ! regulation of cellular response to gamma radiation +is_a: GO:2001229 ! negative regulation of response to gamma radiation +relationship: negatively_regulates GO:0071480 ! cellular response to gamma radiation + +[Term] +id: GO:1905845 +name: positive regulation of cellular response to gamma radiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to gamma radiation." [GO_REF:0000058, GOC:TermGenie, PMID:23505386] +synonym: "activation of cellular response to gamma radiation" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "activation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "positive regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "positive regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "up regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "up-regulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular response to gamma radiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to gamma ray" RELATED [GOC:TermGenie] +synonym: "upregulation of cellular response to gamma-ray photon" RELATED [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1905843 ! regulation of cellular response to gamma radiation +is_a: GO:2001230 ! positive regulation of response to gamma radiation +relationship: positively_regulates GO:0071480 ! cellular response to gamma radiation + +[Term] +id: GO:1905846 +name: regulation of cellular response to oxidopamine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:1905842 ! cellular response to oxidopamine + +[Term] +id: GO:1905847 +name: negative regulation of cellular response to oxidopamine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +synonym: "down regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to oxidopamine" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905846 ! regulation of cellular response to oxidopamine +relationship: negatively_regulates GO:1905842 ! cellular response to oxidopamine + +[Term] +id: GO:1905848 +name: positive regulation of cellular response to oxidopamine +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to oxidopamine." [GO_REF:0000058, GOC:TermGenie, PMID:23721876] +synonym: "activation of cellular response to oxidopamine" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to oxidopamine" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905846 ! regulation of cellular response to oxidopamine +relationship: positively_regulates GO:1905842 ! cellular response to oxidopamine + +[Term] +id: GO:1905849 +name: negative regulation of forward locomotion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] +synonym: "down regulation of forward locomotion" EXACT [GOC:TermGenie] +synonym: "down-regulation of forward locomotion" EXACT [GOC:TermGenie] +synonym: "downregulation of forward locomotion" EXACT [GOC:TermGenie] +synonym: "inhibition of forward locomotion" NARROW [GOC:TermGenie] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0043059 ! regulation of forward locomotion +relationship: negatively_regulates GO:0043056 ! forward locomotion + +[Term] +id: GO:1905850 +name: positive regulation of forward locomotion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of forward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] +synonym: "activation of forward locomotion" NARROW [GOC:TermGenie] +synonym: "up regulation of forward locomotion" EXACT [GOC:TermGenie] +synonym: "up-regulation of forward locomotion" EXACT [GOC:TermGenie] +synonym: "upregulation of forward locomotion" EXACT [GOC:TermGenie] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0043059 ! regulation of forward locomotion +relationship: positively_regulates GO:0043056 ! forward locomotion + +[Term] +id: GO:1905851 +name: negative regulation of backward locomotion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] +synonym: "down regulation of backward locomotion" EXACT [GOC:TermGenie] +synonym: "down-regulation of backward locomotion" EXACT [GOC:TermGenie] +synonym: "downregulation of backward locomotion" EXACT [GOC:TermGenie] +synonym: "inhibition of backward locomotion" NARROW [GOC:TermGenie] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0043058 ! regulation of backward locomotion +relationship: negatively_regulates GO:0043057 ! backward locomotion + +[Term] +id: GO:1905852 +name: positive regulation of backward locomotion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of backward locomotion." [GO_REF:0000058, GOC:TermGenie, PMID:11717360] +synonym: "activation of backward locomotion" NARROW [GOC:TermGenie] +synonym: "up regulation of backward locomotion" EXACT [GOC:TermGenie] +synonym: "up-regulation of backward locomotion" EXACT [GOC:TermGenie] +synonym: "upregulation of backward locomotion" EXACT [GOC:TermGenie] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0043058 ! regulation of backward locomotion +relationship: positively_regulates GO:0043057 ! backward locomotion + +[Term] +id: GO:1905853 +name: regulation of heparan sulfate binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +is_a: GO:0051098 ! regulation of binding + +[Term] +id: GO:1905854 +name: negative regulation of heparan sulfate binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +synonym: "down regulation of heparan sulfate binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of heparan sulfate binding" EXACT [GOC:TermGenie] +synonym: "downregulation of heparan sulfate binding" EXACT [GOC:TermGenie] +synonym: "inhibition of heparan sulfate binding" NARROW [GOC:TermGenie] +is_a: GO:0051100 ! negative regulation of binding +is_a: GO:1905853 ! regulation of heparan sulfate binding + +[Term] +id: GO:1905855 +name: positive regulation of heparan sulfate binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +synonym: "activation of heparan sulfate binding" NARROW [GOC:TermGenie] +synonym: "up regulation of heparan sulfate binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of heparan sulfate binding" EXACT [GOC:TermGenie] +synonym: "upregulation of heparan sulfate binding" EXACT [GOC:TermGenie] +is_a: GO:0051099 ! positive regulation of binding +is_a: GO:1905853 ! regulation of heparan sulfate binding + +[Term] +id: GO:1905856 +name: negative regulation of pentose-phosphate shunt +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259] +is_a: GO:0043456 ! regulation of pentose-phosphate shunt +is_a: GO:0045936 ! negative regulation of phosphate metabolic process +relationship: negatively_regulates GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:1905857 +name: positive regulation of pentose-phosphate shunt +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pentose-phosphate shunt." [GO_REF:0000058, GOC:TermGenie, PMID:19015259] +is_a: GO:0043456 ! regulation of pentose-phosphate shunt +is_a: GO:0045937 ! positive regulation of phosphate metabolic process +relationship: positively_regulates GO:0006098 ! pentose-phosphate shunt + +[Term] +id: GO:1905858 +name: regulation of heparan sulfate proteoglycan binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +synonym: "regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:1905859 +name: negative regulation of heparan sulfate proteoglycan binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +synonym: "down regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "down regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "down-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "down-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "downregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "downregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "inhibition of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie] +synonym: "inhibition of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "negative regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding + +[Term] +id: GO:1905860 +name: positive regulation of heparan sulfate proteoglycan binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of heparan sulfate proteoglycan binding." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7683668] +synonym: "activation of heparan sulfate proteoglycan binding" NARROW [GOC:TermGenie] +synonym: "activation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "positive regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "up regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "up regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "up-regulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "up-regulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +synonym: "upregulation of heparan sulfate proteoglycan binding" EXACT [GOC:TermGenie] +synonym: "upregulation of heparin proteoglycan binding" RELATED [GOC:TermGenie] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:1905858 ! regulation of heparan sulfate proteoglycan binding + +[Term] +id: GO:1905861 +name: intranuclear rod assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form an intranuclear rod." [GO_REF:0000079, GOC:TermGenie, PMID:28074884] +synonym: "intranuclear actin rod assembly" EXACT [GOC:TermGenie] +synonym: "intranuclear actin rod formation" EXACT [GOC:TermGenie] +synonym: "intranuclear rod formation" EXACT [GOC:TermGenie] +is_a: GO:0022607 ! cellular component assembly +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1905862 +name: ferroxidase complex +namespace: cellular_component +def: "A protein complex which is capable of ferroxidase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16522632] +comment: An example of this is FET3 in Saccharomyces cerevisiae (P38993) in PMID:16522632 (inferred from direct assay). +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1905863 +name: obsolete invadopodium organization +namespace: biological_process +def: "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an invadopodium." [GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +is_obsolete: true + +[Term] +id: GO:1905864 +name: regulation of Atg1/ULK1 kinase complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] +synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly + +[Term] +id: GO:1905865 +name: negative regulation of Atg1/ULK1 kinase complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] +synonym: "down regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "inhibition of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1 kinase complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of Atg1p signalling complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1 signaling complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly +relationship: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly + +[Term] +id: GO:1905866 +name: positive regulation of Atg1/ULK1 kinase complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] +synonym: "activation of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ATG1 kinase complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] +synonym: "activation of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of Atg1p signalling complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ULK1 signaling complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] +synonym: "activation of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] +synonym: "activation of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly +relationship: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly + +[Term] +id: GO:1905867 +name: epididymis development +namespace: biological_process +def: "The process whose specific outcome is the progression of an epididymis over time, from its formation to the mature structure." [GO_REF:0000094, GOC:TermGenie, PMID:12388089] +synonym: "epididymus development" EXACT [GOC:TermGenie] +is_a: GO:0035295 ! tube development +is_a: GO:0048608 ! reproductive structure development + +[Term] +id: GO:1905868 +name: regulation of 3'-UTR-mediated mRNA stabilization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +synonym: "regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +is_a: GO:0043488 ! regulation of mRNA stability +relationship: regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization + +[Term] +id: GO:1905869 +name: negative regulation of 3'-UTR-mediated mRNA stabilization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +synonym: "down regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "down regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "down-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "down-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "downregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "downregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "inhibition of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie] +synonym: "inhibition of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie] +synonym: "negative regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization +relationship: negatively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization + +[Term] +id: GO:1905870 +name: positive regulation of 3'-UTR-mediated mRNA stabilization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +synonym: "activation of 3'-untranslated region-mediated mRNA stabilization" NARROW [GOC:TermGenie] +synonym: "activation of 3'-UTR-mediated mRNA stabilization" NARROW [GOC:TermGenie] +synonym: "positive regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "up regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "up regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "up-regulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "up-regulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "upregulation of 3'-untranslated region-mediated mRNA stabilization" EXACT [GOC:TermGenie] +synonym: "upregulation of 3'-UTR-mediated mRNA stabilization" EXACT [GOC:TermGenie] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:1905868 ! regulation of 3'-UTR-mediated mRNA stabilization +relationship: positively_regulates GO:0070935 ! 3'-UTR-mediated mRNA stabilization + +[Term] +id: GO:1905871 +name: regulation of protein localization to cell leading edge +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] +synonym: "regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:1902463 ! protein localization to cell leading edge + +[Term] +id: GO:1905872 +name: negative regulation of protein localization to cell leading edge +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] +synonym: "down regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "down regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "down-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "downregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +synonym: "inhibition of protein localisation in cell leading edge" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localisation to cell leading edge" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization in cell leading edge" NARROW [GOC:TermGenie] +synonym: "inhibition of protein localization to cell leading edge" NARROW [GOC:TermGenie] +synonym: "negative regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "negative regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:1905871 ! regulation of protein localization to cell leading edge +relationship: negatively_regulates GO:1902463 ! protein localization to cell leading edge + +[Term] +id: GO:1905873 +name: positive regulation of protein localization to cell leading edge +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge." [GO_REF:0000058, GOC:TermGenie, PMID:26324884] +synonym: "activation of protein localisation in cell leading edge" NARROW [GOC:TermGenie] +synonym: "activation of protein localisation to cell leading edge" NARROW [GOC:TermGenie] +synonym: "activation of protein localization in cell leading edge" NARROW [GOC:TermGenie] +synonym: "activation of protein localization to cell leading edge" NARROW [GOC:TermGenie] +synonym: "positive regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "positive regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "up regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "up-regulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation in cell leading edge" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localisation to cell leading edge" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization in cell leading edge" EXACT [GOC:TermGenie] +synonym: "upregulation of protein localization to cell leading edge" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:1905871 ! regulation of protein localization to cell leading edge +relationship: positively_regulates GO:1902463 ! protein localization to cell leading edge + +[Term] +id: GO:1905874 +name: regulation of postsynaptic density organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] +synonym: "regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "regulation of PSD organization" EXACT [GOC:TermGenie] +is_a: GO:0033043 ! regulation of organelle organization +is_a: GO:0099175 ! regulation of postsynapse organization +relationship: regulates GO:0097106 ! postsynaptic density organization + +[Term] +id: GO:1905875 +name: negative regulation of postsynaptic density organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] +synonym: "down regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "down regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "down regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "down regulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "down regulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "down-regulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "downregulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "downregulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "downregulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "downregulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "downregulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "inhibition of post synaptic density organization" NARROW [GOC:TermGenie] +synonym: "inhibition of post-synaptic density organization" NARROW [GOC:TermGenie] +synonym: "inhibition of postsynaptic density organisation" NARROW [GOC:TermGenie] +synonym: "inhibition of postsynaptic density organization" NARROW [GOC:TermGenie] +synonym: "inhibition of PSD organization" NARROW [GOC:TermGenie] +synonym: "negative regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "negative regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "negative regulation of PSD organization" EXACT [GOC:TermGenie] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:1905874 ! regulation of postsynaptic density organization +relationship: negatively_regulates GO:0097106 ! postsynaptic density organization + +[Term] +id: GO:1905876 +name: positive regulation of postsynaptic density organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of postsynaptic density organization." [GO_REF:0000058, GOC:TermGenie, PMID:21887379] +synonym: "activation of post synaptic density organization" NARROW [GOC:TermGenie] +synonym: "activation of post-synaptic density organization" NARROW [GOC:TermGenie] +synonym: "activation of postsynaptic density organisation" NARROW [GOC:TermGenie] +synonym: "activation of postsynaptic density organization" NARROW [GOC:TermGenie] +synonym: "activation of PSD organization" NARROW [GOC:TermGenie] +synonym: "positive regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "positive regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "positive regulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "up regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "up regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "up regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "up regulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "up regulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "up-regulation of PSD organization" EXACT [GOC:TermGenie] +synonym: "upregulation of post synaptic density organization" EXACT [GOC:TermGenie] +synonym: "upregulation of post-synaptic density organization" EXACT [GOC:TermGenie] +synonym: "upregulation of postsynaptic density organisation" EXACT [GOC:TermGenie] +synonym: "upregulation of postsynaptic density organization" EXACT [GOC:TermGenie] +synonym: "upregulation of PSD organization" EXACT [GOC:TermGenie] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:1905874 ! regulation of postsynaptic density organization +relationship: positively_regulates GO:0097106 ! postsynaptic density organization + +[Term] +id: GO:1905877 +name: obsolete invadopodium assembly +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form an invadopodium." [GO_REF:0000079, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "invadopodium formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905878 +name: obsolete invadopodium disassembly +namespace: biological_process +def: "OBSOLETE. The disaggregation of an invadopodium into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +is_obsolete: true + +[Term] +id: GO:1905879 +name: regulation of oogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +synonym: "regulation of ovum development" EXACT [GOC:TermGenie] +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:0060284 ! regulation of cell development +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048477 ! oogenesis + +[Term] +id: GO:1905880 +name: negative regulation of oogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +synonym: "down regulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "down regulation of ovum development" EXACT [GOC:TermGenie] +synonym: "down-regulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of ovum development" EXACT [GOC:TermGenie] +synonym: "downregulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of ovum development" EXACT [GOC:TermGenie] +synonym: "inhibition of oogenesis" NARROW [GOC:TermGenie] +synonym: "inhibition of ovum development" NARROW [GOC:TermGenie] +synonym: "negative regulation of ovum development" EXACT [GOC:TermGenie] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905879 ! regulation of oogenesis +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0048477 ! oogenesis + +[Term] +id: GO:1905881 +name: positive regulation of oogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oogenesis." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +synonym: "activation of oogenesis" NARROW [GOC:TermGenie] +synonym: "activation of ovum development" NARROW [GOC:TermGenie] +synonym: "positive regulation of ovum development" EXACT [GOC:TermGenie] +synonym: "up regulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of ovum development" EXACT [GOC:TermGenie] +synonym: "up-regulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of ovum development" EXACT [GOC:TermGenie] +synonym: "upregulation of oogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of ovum development" EXACT [GOC:TermGenie] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905879 ! regulation of oogenesis +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0048477 ! oogenesis + +[Term] +id: GO:1905882 +name: obsolete other organism cell wall +namespace: cellular_component +def: "OBSOLETE. Any cell wall that is part of a other organism." [GO_REF:0000064, GOC:TermGenie, PMID:12438152] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1905883 +name: regulation of triglyceride transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] +synonym: "regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +is_a: GO:1901506 ! regulation of acylglycerol transport +relationship: regulates GO:0034197 ! triglyceride transport + +[Term] +id: GO:1905884 +name: negative regulation of triglyceride transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] +synonym: "down regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "down regulation of triglyceride transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of triglyceride transport" EXACT [GOC:TermGenie] +synonym: "downregulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "downregulation of triglyceride transport" EXACT [GOC:TermGenie] +synonym: "inhibition of triacylglycerol transport" NARROW [GOC:TermGenie] +synonym: "inhibition of triglyceride transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +is_a: GO:1901507 ! negative regulation of acylglycerol transport +is_a: GO:1905883 ! regulation of triglyceride transport +relationship: negatively_regulates GO:0034197 ! triglyceride transport + +[Term] +id: GO:1905885 +name: positive regulation of triglyceride transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of triglyceride transport." [GO_REF:0000058, GOC:TermGenie, PMID:25849533] +synonym: "activation of triacylglycerol transport" NARROW [GOC:TermGenie] +synonym: "activation of triglyceride transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "up regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "up regulation of triglyceride transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of triglyceride transport" EXACT [GOC:TermGenie] +synonym: "upregulation of triacylglycerol transport" EXACT [GOC:TermGenie] +synonym: "upregulation of triglyceride transport" EXACT [GOC:TermGenie] +is_a: GO:1901508 ! positive regulation of acylglycerol transport +is_a: GO:1905883 ! regulation of triglyceride transport +relationship: positively_regulates GO:0034197 ! triglyceride transport + +[Term] +id: GO:1905886 +name: obsolete chromatin remodeling involved in meiosis I +namespace: biological_process +def: "OBSOLETE. Any chromatin remodeling that is involved in meiosis I." [GO_REF:0000060, GOC:TermGenie, PMID:19139281, PMID:25934010, PMID:9106659] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "chromatin modeling involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "chromatin modelling involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "chromatin remodelling involved in meiosis I" EXACT [GOC:TermGenie] +synonym: "meiosis-specific chromatin remodeling" EXACT [PMID:19139281] +is_obsolete: true + +[Term] +id: GO:1905887 +name: autoinducer AI-2 transmembrane transport +namespace: biological_process +def: "The process in which (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol (autoinducer AI-2) is transported across a membrane. AI-2 is produced by prokaryotes and is believed to play a role in quorum sensing." [GO_REF:0000069, GOC:TermGenie, PMID:15601708] +synonym: "(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport" EXACT [PMID:15601708] +synonym: "AI-2 transmembrane transport" EXACT [PMID:15601708] +synonym: "autoinducer 2 transmembrane transport" EXACT [PMID:15601708] +is_a: GO:0015791 ! polyol transport +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1905888 +name: negative regulation of cellular response to very-low-density lipoprotein particle stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] +synonym: "down regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "down regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie] +synonym: "inhibition of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie] +synonym: "negative regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus +relationship: negatively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus + +[Term] +id: GO:1905889 +name: positive regulation of cellular response to very-low-density lipoprotein particle stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] +synonym: "activation of cellular response to very-low-density lipoprotein particle stimulus" NARROW [GOC:TermGenie] +synonym: "activation of cellular response to VLDL particle stimulus" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to very-low-density lipoprotein particle stimulus" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905890 ! regulation of cellular response to very-low-density lipoprotein particle stimulus +relationship: positively_regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus + +[Term] +id: GO:1905890 +name: regulation of cellular response to very-low-density lipoprotein particle stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to very-low-density lipoprotein particle stimulus." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:7592957] +synonym: "regulation of cellular response to VLDL particle stimulus" EXACT [GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0090731 ! cellular response to very-low-density lipoprotein particle stimulus + +[Term] +id: GO:1905891 +name: regulation of cellular response to thapsigargin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:1904579 ! cellular response to thapsigargin + +[Term] +id: GO:1905892 +name: negative regulation of cellular response to thapsigargin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "down regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to thapsigargin" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905891 ! regulation of cellular response to thapsigargin +relationship: negatively_regulates GO:1904579 ! cellular response to thapsigargin + +[Term] +id: GO:1905893 +name: positive regulation of cellular response to thapsigargin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to thapsigargin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "activation of cellular response to thapsigargin" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to thapsigargin" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905891 ! regulation of cellular response to thapsigargin +relationship: positively_regulates GO:1904579 ! cellular response to thapsigargin + +[Term] +id: GO:1905894 +name: regulation of cellular response to tunicamycin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:1904577 ! cellular response to tunicamycin + +[Term] +id: GO:1905895 +name: negative regulation of cellular response to tunicamycin +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "down regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to tunicamycin" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905894 ! regulation of cellular response to tunicamycin +relationship: negatively_regulates GO:1904577 ! cellular response to tunicamycin + +[Term] +id: GO:1905896 +name: positive regulation of cellular response to tunicamycin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to tunicamycin." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "activation of cellular response to tunicamycin" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to tunicamycin" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905894 ! regulation of cellular response to tunicamycin +relationship: positively_regulates GO:1904577 ! cellular response to tunicamycin + +[Term] +id: GO:1905897 +name: regulation of response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "regulation of response to ER stress" EXACT [GOC:TermGenie] +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:1905898 +name: positive regulation of response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to endoplasmic reticulum stress." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:21803450] +synonym: "activation of cellular response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "activation of ER stress response" NARROW [GOC:TermGenie] +synonym: "activation of response to endoplasmic reticulum stress" NARROW [GOC:TermGenie] +synonym: "activation of response to ER stress" NARROW [GOC:TermGenie] +synonym: "positive regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "positive regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "positive regulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "up regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "up regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up regulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to ER stress" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of ER stress response" EXACT [GOC:TermGenie] +synonym: "upregulation of response to endoplasmic reticulum stress" EXACT [GOC:TermGenie] +synonym: "upregulation of response to ER stress" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905897 ! regulation of response to endoplasmic reticulum stress +relationship: positively_regulates GO:0034976 ! response to endoplasmic reticulum stress + +[Term] +id: GO:1905899 +name: regulation of smooth muscle tissue development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] +is_a: GO:1901861 ! regulation of muscle tissue development +relationship: regulates GO:0048745 ! smooth muscle tissue development + +[Term] +id: GO:1905900 +name: negative regulation of smooth muscle tissue development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] +synonym: "down regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +synonym: "down-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +synonym: "downregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +synonym: "inhibition of smooth muscle tissue development" NARROW [GOC:TermGenie] +is_a: GO:1901862 ! negative regulation of muscle tissue development +is_a: GO:1905899 ! regulation of smooth muscle tissue development +relationship: negatively_regulates GO:0048745 ! smooth muscle tissue development + +[Term] +id: GO:1905901 +name: positive regulation of smooth muscle tissue development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:14709716] +synonym: "activation of smooth muscle tissue development" NARROW [GOC:TermGenie] +synonym: "up regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +synonym: "up-regulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +synonym: "upregulation of smooth muscle tissue development" EXACT [GOC:TermGenie] +is_a: GO:1901863 ! positive regulation of muscle tissue development +is_a: GO:1905899 ! regulation of smooth muscle tissue development +relationship: positively_regulates GO:0048745 ! smooth muscle tissue development + +[Term] +id: GO:1905902 +name: regulation of mesoderm formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0001707 ! mesoderm formation + +[Term] +id: GO:1905903 +name: negative regulation of mesoderm formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] +synonym: "down regulation of mesoderm formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of mesoderm formation" EXACT [GOC:TermGenie] +synonym: "downregulation of mesoderm formation" EXACT [GOC:TermGenie] +synonym: "inhibition of mesoderm formation" NARROW [GOC:TermGenie] +is_a: GO:1905902 ! regulation of mesoderm formation +is_a: GO:2000381 ! negative regulation of mesoderm development +relationship: negatively_regulates GO:0001707 ! mesoderm formation + +[Term] +id: GO:1905904 +name: positive regulation of mesoderm formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm formation." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:23939491] +synonym: "activation of mesoderm formation" NARROW [GOC:TermGenie] +synonym: "up regulation of mesoderm formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of mesoderm formation" EXACT [GOC:TermGenie] +synonym: "upregulation of mesoderm formation" EXACT [GOC:TermGenie] +is_a: GO:1905902 ! regulation of mesoderm formation +is_a: GO:2000382 ! positive regulation of mesoderm development +relationship: positively_regulates GO:0001707 ! mesoderm formation + +[Term] +id: GO:1905905 +name: pharyngeal gland morphogenesis +namespace: biological_process +def: "The developmental process by which a pharyngeal gland is generated and organized." [GO_REF:0000083, GOC:TermGenie, PMID:21868609] +synonym: "glandulae pharyngeae morphogenesis" RELATED [GOC:TermGenie] +synonym: "pharynx gland morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0022612 ! gland morphogenesis + +[Term] +id: GO:1905906 +name: regulation of amyloid fibril formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] +comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). +synonym: "regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "regulation of amyloid structure formation" RELATED [GOC:TermGenie] +is_a: GO:0051246 ! regulation of protein metabolic process +is_a: GO:1902903 ! regulation of supramolecular fiber organization +relationship: regulates GO:1990000 ! amyloid fibril formation + +[Term] +id: GO:1905907 +name: negative regulation of amyloid fibril formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] +comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). +synonym: "down regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "down regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "down regulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "down-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "down-regulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "downregulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "downregulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "downregulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "inhibition of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of amyloid fibril formation" NARROW [GOC:TermGenie] +synonym: "inhibition of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "inhibition of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "negative regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "negative regulation of amyloid structure formation" RELATED [GOC:TermGenie] +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:1902904 ! negative regulation of supramolecular fiber organization +is_a: GO:1905906 ! regulation of amyloid fibril formation +relationship: negatively_regulates GO:1990000 ! amyloid fibril formation + +[Term] +id: GO:1905908 +name: positive regulation of amyloid fibril formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amyloid fibril formation." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:23106396] +comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). +synonym: "activation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "activation of amyloid fibril formation" NARROW [GOC:TermGenie] +synonym: "activation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "activation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "positive regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "positive regulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "up regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "up regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "up regulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "up-regulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "up-regulation of amyloid structure formation" RELATED [GOC:TermGenie] +synonym: "upregulation of amyloid fibril assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of amyloid fibril formation" EXACT [GOC:TermGenie] +synonym: "upregulation of amyloid structure assembly" RELATED [GOC:TermGenie] +synonym: "upregulation of amyloid structure formation" RELATED [GOC:TermGenie] +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:1902905 ! positive regulation of supramolecular fiber organization +is_a: GO:1905906 ! regulation of amyloid fibril formation +relationship: positively_regulates GO:1990000 ! amyloid fibril formation + +[Term] +id: GO:1905909 +name: regulation of dauer entry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] +synonym: "regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +is_a: GO:0061065 ! regulation of dauer larval development +relationship: regulates GO:0043053 ! dauer entry + +[Term] +id: GO:1905910 +name: negative regulation of dauer entry +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] +synonym: "down regulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "down regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "down-regulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "down-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "downregulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "downregulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "inhibition of dauer entry" NARROW [GOC:TermGenie] +synonym: "inhibition of nematode entry into dormancy" NARROW [GOC:TermGenie] +synonym: "negative regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +is_a: GO:0061067 ! negative regulation of dauer larval development +is_a: GO:1905909 ! regulation of dauer entry +relationship: negatively_regulates GO:0043053 ! dauer entry + +[Term] +id: GO:1905911 +name: positive regulation of dauer entry +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dauer entry." [GO_REF:0000058, GOC:TermGenie, PMID:21531333] +synonym: "activation of dauer entry" NARROW [GOC:TermGenie] +synonym: "activation of nematode entry into dormancy" NARROW [GOC:TermGenie] +synonym: "positive regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "up regulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "up regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "up-regulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "up-regulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +synonym: "upregulation of dauer entry" EXACT [GOC:TermGenie] +synonym: "upregulation of nematode entry into dormancy" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1905909 ! regulation of dauer entry +relationship: positively_regulates GO:0043053 ! dauer entry + +[Term] +id: GO:1905912 +name: regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "regulation of calcium ion export from cell" EXACT [] +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +relationship: regulates GO:1990034 ! calcium ion export across plasma membrane + +[Term] +id: GO:1905913 +name: negative regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "down regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion efflux from cell" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium ion export from cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of calcium ion export from cell" EXACT [] +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane +relationship: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane + +[Term] +id: GO:1905914 +name: positive regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "activation of calcium ion efflux from cell" NARROW [GOC:TermGenie] +synonym: "activation of calcium ion export from cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium ion export from cell" EXACT [] +synonym: "up regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion export from cell" EXACT [GOC:TermGenie] +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane +relationship: positively_regulates GO:1990034 ! calcium ion export across plasma membrane + +[Term] +id: GO:1905915 +name: regulation of cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0090679 ! cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905916 +name: negative regulation of cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "down regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "downregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "inhibition of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:1900240 ! negative regulation of phenotypic switching +is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching +relationship: negatively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905917 +name: positive regulation of cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "activation of cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "up regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "upregulation of cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching +relationship: positively_regulates GO:0090679 ! cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905918 +name: regulation of CoA-transferase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:1905919 +name: negative regulation of CoA-transferase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +synonym: "down regulation of CoA-transferase activity" EXACT [GOC:TermGenie] +synonym: "down-regulation of CoA-transferase activity" EXACT [GOC:TermGenie] +synonym: "downregulation of CoA-transferase activity" EXACT [GOC:TermGenie] +synonym: "inhibition of CoA-transferase activity" NARROW [GOC:TermGenie] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:1905918 ! regulation of CoA-transferase activity + +[Term] +id: GO:1905920 +name: positive regulation of CoA-transferase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CoA-transferase activity." [GO_REF:0000059, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +synonym: "activation of CoA-transferase activity" NARROW [GOC:TermGenie] +synonym: "up regulation of CoA-transferase activity" EXACT [GOC:TermGenie] +synonym: "up-regulation of CoA-transferase activity" EXACT [GOC:TermGenie] +synonym: "upregulation of CoA-transferase activity" EXACT [GOC:TermGenie] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:1905918 ! regulation of CoA-transferase activity + +[Term] +id: GO:1905921 +name: regulation of acetylcholine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +synonym: "regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0060408 ! regulation of acetylcholine metabolic process +relationship: regulates GO:0008292 ! acetylcholine biosynthetic process + +[Term] +id: GO:1905922 +name: negative regulation of acetylcholine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +synonym: "down regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "down regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "down regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "downregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "inhibition of acetylcholine anabolism" NARROW [GOC:TermGenie] +synonym: "inhibition of acetylcholine biosynthesis" NARROW [GOC:TermGenie] +synonym: "inhibition of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "inhibition of acetylcholine formation" NARROW [GOC:TermGenie] +synonym: "inhibition of acetylcholine synthesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "negative regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "negative regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "negative regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0060410 ! negative regulation of acetylcholine metabolic process +is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process +relationship: negatively_regulates GO:0008292 ! acetylcholine biosynthetic process + +[Term] +id: GO:1905923 +name: positive regulation of acetylcholine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acetylcholine biosynthetic process." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:20164328] +synonym: "activation of acetylcholine anabolism" NARROW [GOC:TermGenie] +synonym: "activation of acetylcholine biosynthesis" NARROW [GOC:TermGenie] +synonym: "activation of acetylcholine biosynthetic process" NARROW [GOC:TermGenie] +synonym: "activation of acetylcholine formation" NARROW [GOC:TermGenie] +synonym: "activation of acetylcholine synthesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "positive regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "positive regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "positive regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "up regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylcholine anabolism" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylcholine biosynthesis" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylcholine biosynthetic process" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylcholine formation" EXACT [GOC:TermGenie] +synonym: "upregulation of acetylcholine synthesis" EXACT [GOC:TermGenie] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0060409 ! positive regulation of acetylcholine metabolic process +is_a: GO:1905921 ! regulation of acetylcholine biosynthetic process +relationship: positively_regulates GO:0008292 ! acetylcholine biosynthetic process + +[Term] +id: GO:1905924 +name: obsolete regulation of invadopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "regulation of invadopodium formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905925 +name: obsolete negative regulation of invadopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "down regulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "down regulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "down-regulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "downregulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "downregulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "inhibition of invadopodium assembly" NARROW [GOC:TermGenie] +synonym: "inhibition of invadopodium formation" NARROW [GOC:TermGenie] +synonym: "negative regulation of invadopodium formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905926 +name: obsolete positive regulation of invadopodium assembly +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium assembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "activation of invadopodium assembly" NARROW [GOC:TermGenie] +synonym: "activation of invadopodium formation" NARROW [GOC:TermGenie] +synonym: "positive regulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "up regulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "up regulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "up-regulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of invadopodium formation" EXACT [GOC:TermGenie] +synonym: "upregulation of invadopodium assembly" EXACT [GOC:TermGenie] +synonym: "upregulation of invadopodium formation" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905927 +name: obsolete regulation of invadopodium disassembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +is_obsolete: true + +[Term] +id: GO:1905928 +name: obsolete negative regulation of invadopodium disassembly +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "down regulation of invadopodium disassembly" EXACT [GOC:TermGenie] +synonym: "down-regulation of invadopodium disassembly" EXACT [GOC:TermGenie] +synonym: "downregulation of invadopodium disassembly" EXACT [GOC:TermGenie] +synonym: "inhibition of invadopodium disassembly" NARROW [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905929 +name: obsolete positive regulation of invadopodium disassembly +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of invadopodium disassembly." [GO_REF:0000058, GOC:TermGenie, PMID:15684033] +comment: This term was made obsolete because an invadopodium is an abnormal structure found in cancerous or transformed cells that is out of scope of GO. +synonym: "activation of invadopodium disassembly" NARROW [GOC:TermGenie] +synonym: "up regulation of invadopodium disassembly" EXACT [GOC:TermGenie] +synonym: "up-regulation of invadopodium disassembly" EXACT [GOC:TermGenie] +synonym: "upregulation of invadopodium disassembly" EXACT [GOC:TermGenie] +is_obsolete: true + +[Term] +id: GO:1905930 +name: regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905915 ! regulation of cell differentiation involved in phenotypic switching +relationship: regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905931 +name: negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "down-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "down-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "downregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "downregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "downregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "downregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "inhibition of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "inhibition of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "inhibition of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "inhibition of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [] +synonym: "negative regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "negative regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905916 ! negative regulation of cell differentiation involved in phenotypic switching +is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching +relationship: negatively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905932 +name: positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25089138] +synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "activation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "activation of vascular smooth muscle cell differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "activation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "activation of VSMC differentiation involved in phenotypic switching" NARROW [GOC:TermGenie] +synonym: "positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "positive regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "positive regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "positive regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up-regulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "up-regulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "up-regulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "upregulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "upregulation of vascular smooth muscle cell differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +synonym: "upregulation of VSMC differentiation involved in phenotypic dimorphism" RELATED [GOC:TermGenie] +synonym: "upregulation of VSMC differentiation involved in phenotypic switching" EXACT [GOC:TermGenie] +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905917 ! positive regulation of cell differentiation involved in phenotypic switching +is_a: GO:1905930 ! regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching +relationship: positively_regulates GO:1905420 ! vascular associated smooth muscle cell differentiation involved in phenotypic switching + +[Term] +id: GO:1905933 +name: regulation of cell fate determination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0001709 ! cell fate determination + +[Term] +id: GO:1905934 +name: negative regulation of cell fate determination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] +synonym: "down regulation of cell fate determination" EXACT [GOC:TermGenie] +synonym: "down-regulation of cell fate determination" EXACT [GOC:TermGenie] +synonym: "downregulation of cell fate determination" EXACT [GOC:TermGenie] +synonym: "inhibition of cell fate determination" NARROW [GOC:TermGenie] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:1905933 ! regulation of cell fate determination +relationship: negatively_regulates GO:0001709 ! cell fate determination + +[Term] +id: GO:1905935 +name: positive regulation of cell fate determination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell fate determination." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25793578] +synonym: "activation of cell fate determination" NARROW [GOC:TermGenie] +synonym: "up regulation of cell fate determination" EXACT [GOC:TermGenie] +synonym: "up-regulation of cell fate determination" EXACT [GOC:TermGenie] +synonym: "upregulation of cell fate determination" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1905933 ! regulation of cell fate determination +relationship: positively_regulates GO:0001709 ! cell fate determination + +[Term] +id: GO:1905936 +name: regulation of germ cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +is_a: GO:0042127 ! regulation of cell population proliferation +is_a: GO:0051239 ! regulation of multicellular organismal process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0036093 ! germ cell proliferation + +[Term] +id: GO:1905937 +name: negative regulation of germ cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +synonym: "down regulation of germ cell proliferation" EXACT [GOC:TermGenie] +synonym: "down-regulation of germ cell proliferation" EXACT [GOC:TermGenie] +synonym: "downregulation of germ cell proliferation" EXACT [GOC:TermGenie] +synonym: "inhibition of germ cell proliferation" NARROW [GOC:TermGenie] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905936 ! regulation of germ cell proliferation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0036093 ! germ cell proliferation + +[Term] +id: GO:1905938 +name: positive regulation of germ cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of germ cell proliferation." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +synonym: "activation of germ cell proliferation" NARROW [GOC:TermGenie] +synonym: "up regulation of germ cell proliferation" EXACT [GOC:TermGenie] +synonym: "up-regulation of germ cell proliferation" EXACT [GOC:TermGenie] +synonym: "upregulation of germ cell proliferation" EXACT [GOC:TermGenie] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905936 ! regulation of germ cell proliferation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0036093 ! germ cell proliferation + +[Term] +id: GO:1905939 +name: regulation of gonad development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +synonym: "regulation of gonadogenesis" EXACT [GOC:TermGenie] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0008406 ! gonad development + +[Term] +id: GO:1905940 +name: negative regulation of gonad development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +synonym: "down regulation of gonad development" EXACT [GOC:TermGenie] +synonym: "down regulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of gonad development" EXACT [GOC:TermGenie] +synonym: "down-regulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of gonad development" EXACT [GOC:TermGenie] +synonym: "downregulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of gonad development" NARROW [GOC:TermGenie] +synonym: "inhibition of gonadogenesis" NARROW [GOC:TermGenie] +synonym: "negative regulation of gonadogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1905939 ! regulation of gonad development +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0008406 ! gonad development + +[Term] +id: GO:1905941 +name: positive regulation of gonad development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gonad development." [GO_REF:0000058, GOC:TermGenie, PMID:15342467] +synonym: "activation of gonad development" NARROW [GOC:TermGenie] +synonym: "activation of gonadogenesis" NARROW [GOC:TermGenie] +synonym: "positive regulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "up regulation of gonad development" EXACT [GOC:TermGenie] +synonym: "up regulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of gonad development" EXACT [GOC:TermGenie] +synonym: "up-regulation of gonadogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of gonad development" EXACT [GOC:TermGenie] +synonym: "upregulation of gonadogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1905939 ! regulation of gonad development +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0008406 ! gonad development + +[Term] +id: GO:1905942 +name: regulation of formation of growth cone in injured axon +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +is_a: GO:0048686 ! regulation of sprouting of injured axon +relationship: regulates GO:0048689 ! formation of growth cone in injured axon + +[Term] +id: GO:1905943 +name: negative regulation of formation of growth cone in injured axon +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +synonym: "down regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +synonym: "down-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +synonym: "downregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +synonym: "inhibition of formation of growth cone in injured axon" NARROW [GOC:TermGenie] +is_a: GO:0048688 ! negative regulation of sprouting of injured axon +is_a: GO:1905942 ! regulation of formation of growth cone in injured axon +relationship: negatively_regulates GO:0048689 ! formation of growth cone in injured axon + +[Term] +id: GO:1905944 +name: positive regulation of formation of growth cone in injured axon +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon." [GO_REF:0000058, GOC:TermGenie, PMID:19737525] +synonym: "activation of formation of growth cone in injured axon" NARROW [GOC:TermGenie] +synonym: "up regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +synonym: "up-regulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +synonym: "upregulation of formation of growth cone in injured axon" EXACT [GOC:TermGenie] +is_a: GO:0048687 ! positive regulation of sprouting of injured axon +is_a: GO:1905942 ! regulation of formation of growth cone in injured axon +relationship: positively_regulates GO:0048689 ! formation of growth cone in injured axon + +[Term] +id: GO:1905945 +name: regulation of response to calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] +synonym: "regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0051592 ! response to calcium ion + +[Term] +id: GO:1905946 +name: negative regulation of response to calcium ion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] +synonym: "down regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "down regulation of response to calcium ion" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "down-regulation of response to calcium ion" EXACT [GOC:TermGenie] +synonym: "downregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "downregulation of response to calcium ion" EXACT [GOC:TermGenie] +synonym: "inhibition of response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "inhibition of response to calcium ion" NARROW [GOC:TermGenie] +synonym: "negative regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:1905945 ! regulation of response to calcium ion +relationship: negatively_regulates GO:0051592 ! response to calcium ion + +[Term] +id: GO:1905947 +name: positive regulation of response to calcium ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to calcium ion." [GO_REF:0000058, GOC:aruk, GOC:bc, GOC:TermGenie, PMID:11404397] +synonym: "activation of response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "activation of response to calcium ion" NARROW [GOC:TermGenie] +synonym: "positive regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up regulation of response to calcium ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of response to calcium ion" EXACT [GOC:TermGenie] +synonym: "upregulation of response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "upregulation of response to calcium ion" EXACT [GOC:TermGenie] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:1905945 ! regulation of response to calcium ion +relationship: positively_regulates GO:0051592 ! response to calcium ion + +[Term] +id: GO:1905948 +name: ABC-type 3',5'-cyclic GMP transmembrane transporter activity +namespace: molecular_function +def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + 3',5'-cyclic GMP(in) = ADP + phosphate + 3',5'-cyclic GMP(out)." [GO_REF:0000070, GOC:TermGenie, PMID:18310115] +synonym: "3',5'-cyclic GMP transmembrane-transporting ATPase activity" EXACT [] +synonym: "ATP-dependent 3',5'-cyclic GMP transmembrane transporter activity" EXACT [] +synonym: "ATPase-coupled 3',5'-cyclic GMP transmembrane transporter activity" RELATED [] +synonym: "ATPase-coupled cGMP transmembrane transporter activity" EXACT [] +is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity +is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity +is_a: GO:0008514 ! organic anion transmembrane transporter activity +is_a: GO:0022853 ! active ion transmembrane transporter activity +is_a: GO:0140359 ! ABC-type transporter activity + +[Term] +id: GO:1905949 +name: negative regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay). +synonym: "down regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] +is_a: GO:0010523 ! negative regulation of calcium ion transport into cytosol +is_a: GO:0090281 ! negative regulation of calcium ion import +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane +relationship: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane + +[Term] +id: GO:1905951 +name: mitochondrion DNA recombination +namespace: biological_process +def: "Any DNA recombination that takes place in mitochondrion." [GO_REF:0000062, GOC:TermGenie, PMID:8087883] +synonym: "DNA recombination in mitochondria" EXACT [GOC:TermGenie] +is_a: GO:0006310 ! DNA recombination +is_a: GO:0032042 ! mitochondrial DNA metabolic process + +[Term] +id: GO:1905952 +name: regulation of lipid localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] +synonym: "regulation of lipid localisation" EXACT [GOC:TermGenie] +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0010876 ! lipid localization + +[Term] +id: GO:1905953 +name: negative regulation of lipid localization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] +synonym: "down regulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "down regulation of lipid localization" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "down-regulation of lipid localization" EXACT [GOC:TermGenie] +synonym: "downregulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "downregulation of lipid localization" EXACT [GOC:TermGenie] +synonym: "inhibition of lipid localisation" NARROW [GOC:TermGenie] +synonym: "inhibition of lipid localization" NARROW [GOC:TermGenie] +synonym: "negative regulation of lipid localisation" EXACT [GOC:TermGenie] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:1905952 ! regulation of lipid localization +relationship: negatively_regulates GO:0010876 ! lipid localization + +[Term] +id: GO:1905954 +name: positive regulation of lipid localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lipid localization." [GO_REF:0000058, GOC:TermGenie, PMID:17564681] +synonym: "activation of lipid localisation" NARROW [GOC:TermGenie] +synonym: "activation of lipid localization" NARROW [GOC:TermGenie] +synonym: "positive regulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "up regulation of lipid localization" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "up-regulation of lipid localization" EXACT [GOC:TermGenie] +synonym: "upregulation of lipid localisation" EXACT [GOC:TermGenie] +synonym: "upregulation of lipid localization" EXACT [GOC:TermGenie] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:1905952 ! regulation of lipid localization +relationship: positively_regulates GO:0010876 ! lipid localization + +[Term] +id: GO:1905955 +name: negative regulation of endothelial tube morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] +synonym: "down regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +synonym: "down-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +synonym: "downregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +synonym: "inhibition of endothelial tube morphogenesis" NARROW [GOC:TermGenie] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:1901509 ! regulation of endothelial tube morphogenesis +is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium +relationship: negatively_regulates GO:0061154 ! endothelial tube morphogenesis + +[Term] +id: GO:1905956 +name: positive regulation of endothelial tube morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:25961718] +synonym: "activation of endothelial tube morphogenesis" NARROW [GOC:TermGenie] +synonym: "up regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +synonym: "up-regulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +synonym: "upregulation of endothelial tube morphogenesis" EXACT [GOC:TermGenie] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:1901509 ! regulation of endothelial tube morphogenesis +is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium +relationship: positively_regulates GO:0061154 ! endothelial tube morphogenesis + +[Term] +id: GO:1905957 +name: regulation of cellular response to alcohol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:1901419 ! regulation of response to alcohol +relationship: regulates GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:1905958 +name: negative regulation of cellular response to alcohol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +synonym: "down regulation of cellular response to alcohol" EXACT [GOC:TermGenie] +synonym: "down-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] +synonym: "downregulation of cellular response to alcohol" EXACT [GOC:TermGenie] +synonym: "inhibition of cellular response to alcohol" NARROW [GOC:TermGenie] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1901420 ! negative regulation of response to alcohol +is_a: GO:1905957 ! regulation of cellular response to alcohol +relationship: negatively_regulates GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:1905959 +name: positive regulation of cellular response to alcohol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to alcohol." [GO_REF:0000058, GOC:TermGenie, PMID:26434723] +synonym: "activation of cellular response to alcohol" NARROW [GOC:TermGenie] +synonym: "up regulation of cellular response to alcohol" EXACT [GOC:TermGenie] +synonym: "up-regulation of cellular response to alcohol" EXACT [GOC:TermGenie] +synonym: "upregulation of cellular response to alcohol" EXACT [GOC:TermGenie] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1901421 ! positive regulation of response to alcohol +is_a: GO:1905957 ! regulation of cellular response to alcohol +relationship: positively_regulates GO:0097306 ! cellular response to alcohol + +[Term] +id: GO:1905960 +name: response to differentiation-inducing factor 2 +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one stimulus." [GO_REF:0000071, GOC:rjd, GOC:TermGenie, PMID:19684855, PMID:3355503] +synonym: "response to 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one" EXACT [] +synonym: "response to DIF-2" RELATED [] +synonym: "response to DIF2" RELATED [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:0045472 ! response to ether +is_a: GO:1901654 ! response to ketone + +[Term] +id: GO:1905961 +name: protein-cysteine S-palmitoyltransferase complex +namespace: cellular_component +def: "A protein complex which is capable of protein-cysteine S-palmitoyltransferase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20851885] +comment: An example of this is ERF2 in Saccharomyces cerevisiae (Q06551) in PMID:20851885 (inferred from direct assay) +synonym: "Palmitoyltransferase ERF2-SHR5 complex" NARROW [] +synonym: "Palmitoyltransferase ERF2/SHR5 complex" NARROW [] +is_a: GO:0002178 ! palmitoyltransferase complex + +[Term] +id: GO:1905962 +name: glutamatergic neuron differentiation +namespace: biological_process +def: "The process in which a relatively unspecialized cell acquires the specialized features of a glutamatergic neuron." [GO_REF:0000086, GOC:TermGenie, PMID:24030726] +is_a: GO:0030182 ! neuron differentiation + +[Term] +id: GO:1990000 +name: amyloid fibril formation +namespace: biological_process +def: "The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins." [GOC:cvs, GOC:jj, GOC:ppm, GOC:sj, PMID:21148556, PMID:22817896, PMID:28937655, PMID:29654159] +comment: Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). +synonym: "amyloid fibril assembly" RELATED [] +synonym: "amyloid structure assembly" RELATED [] +synonym: "amyloid structure formation" RELATED [] +is_a: GO:0019538 ! protein metabolic process +is_a: GO:0097435 ! supramolecular fiber organization + +[Term] +id: GO:1990001 +name: inhibition of cysteine-type endopeptidase activity involved in apoptotic process +namespace: biological_process +def: "Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." [GOC:mtg_apoptosis, PMID:11943137] +is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:0097340 ! inhibition of cysteine-type endopeptidase activity + +[Term] +id: GO:1990002 +name: methylglyoxal reductase (NADPH-dependent, acetol producing) +namespace: molecular_function +def: "Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+." [EC:1.1.1.-, MetaCyc:RXN0-4281, PMID:16077126, RHEA:27986] +xref: RHEA:27986 +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:1990003 +name: inosine-diphosphatase activity +namespace: molecular_function +alt_id: GO:0090450 +def: "Catalysis of the reaction: IDP + H2O = IMP + phosphate." [PMID:20385596, PMID:22849572, RHEA:35207] +synonym: "IDP phosphatase activity" EXACT [] +synonym: "IDPase activity" EXACT [] +synonym: "inosine diphosphatase activity" EXACT [] +xref: EC:3.6.1.64 +xref: Reactome:R-HSA-2509816 "NUDT16 hydrolyses IDP to IMP" +xref: RHEA:35207 +is_a: GO:0017110 ! nucleoside-diphosphatase activity +is_a: GO:0098519 ! nucleotide phosphatase activity, acting on free nucleotides + +[Term] +id: GO:1990004 +name: obsolete XDP phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: XDP + H2O = XMP + phosphate." [PMID:20385596] +comment: This term was obsoleted because there is no evidence that this reaction exist in vivo. +is_obsolete: true + +[Term] +id: GO:1990005 +name: granular vesicle +namespace: cellular_component +def: "A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells." [NIF_Subcellular:sao478230652] +xref: NIF_Subcellular:sao478230652 +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:1990006 +name: amorphous vesicle +namespace: cellular_component +def: "A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway." [NIF_Subcellular:sao1531915298, PMID:11896161] +xref: NIF_Subcellular:sao1531915298 +is_a: GO:0031410 ! cytoplasmic vesicle + +[Term] +id: GO:1990007 +name: membrane stack +namespace: cellular_component +def: "A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures." [ISBN:9780195065718, NIF_Subcellular:sao2114874506] +xref: NIF_Subcellular:sao2114874506 +is_a: GO:0005783 ! endoplasmic reticulum + +[Term] +id: GO:1990008 +name: neurosecretory vesicle +namespace: cellular_component +def: "A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus." [ISBN:0195065719, NIF_Subcellular:sao2031592629] +xref: NIF_Subcellular:sao2031592629 +is_a: GO:1990005 ! granular vesicle + +[Term] +id: GO:1990009 +name: retinal cell apoptotic process +namespace: biological_process +alt_id: GO:0046674 +def: "Any apoptotic process in a retinal cell." [GOC:mtg_apoptosis, PMID:15558487, PMID:24664675] +synonym: "induction of retinal programmed cell death" RELATED [] +is_a: GO:0006915 ! apoptotic process + +[Term] +id: GO:1990010 +name: compound eye retinal cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a compound eye retinal cell." [GOC:mtg_apoptosis, PMID:12021768] +is_a: GO:1990009 ! retinal cell apoptotic process + +[Term] +id: GO:1990011 +name: laminated body +namespace: cellular_component +def: "Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus." [ISBN:0195065719, NIF_Subcellular:sao506721981] +synonym: "laminated inclusion body" EXACT [] +xref: NIF_Subcellular:sao506721981 +is_a: GO:0016234 ! inclusion body + +[Term] +id: GO:1990012 +name: complex laminated body +namespace: cellular_component +def: "A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint." [NIF_Subcellular:nlx_151681] +synonym: "CLB" RELATED [] +xref: NIF_Subcellular:nlx_151681 +is_a: GO:1990011 ! laminated body + +[Term] +id: GO:1990013 +name: presynaptic grid +namespace: cellular_component +def: "A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane." [ISBN:0716723808, NIF_Subcellular:sao1730664005] +synonym: "pre-synaptic grid" EXACT [] +xref: NIF_Subcellular:sao1730664005 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0048786 ! presynaptic active zone + +[Term] +id: GO:1990014 +name: orthogonal array +namespace: cellular_component +def: "Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels)." [NIF_Subcellular:sao1747012216, PMID:22718347] +synonym: "OAP" RELATED [] +synonym: "orthogonal array of particles" EXACT [] +synonym: "square array" RELATED [] +xref: NIF_Subcellular:sao1747012216 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005886 ! plasma membrane + +[Term] +id: GO:1990015 +name: ensheathing process +namespace: cellular_component +def: "A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma." [NIF_Subcellular:sao1376748732] +synonym: "ensheathing process of Schwann cell" NARROW [] +xref: NIF_Subcellular:sao1376748732 +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:1990016 +name: neck portion of tanycyte +namespace: cellular_component +def: "Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao901230115] +synonym: "neck portion" BROAD [] +xref: NIF_Subcellular:sao901230115 +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:1990017 +name: somatic portion of tanycyte +namespace: cellular_component +def: "Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS." [ISBN:0195065719, NIF_Subcellular:sao401910342] +synonym: "somatic portion" BROAD [] +xref: NIF_Subcellular:sao401910342 +is_a: GO:0044297 ! cell body + +[Term] +id: GO:1990018 +name: tail portion of tanycyte +namespace: cellular_component +def: "Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell." [ISBN:0195065719, NIF_Subcellular:sao1749953771] +synonym: "tail portion" BROAD [] +xref: NIF_Subcellular:sao1749953771 +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:1990019 +name: protein storage vacuole organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole." [GOC:tb, PMID:21670741] +is_a: GO:0007033 ! vacuole organization + +[Term] +id: GO:1990020 +name: recurrent axon collateral +namespace: cellular_component +def: "Axon collateral that ramifies in the area of the soma of the cell of origin." [NIF_Subcellular:sao1642494436] +synonym: "recurrent collateral" BROAD [] +xref: NIF_Subcellular:sao1642494436 +is_a: GO:0044303 ! axon collateral + +[Term] +id: GO:1990021 +name: Schaffer axon collateral +namespace: cellular_component +def: "Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1." [NIF_Subcellular:nlx_subcell_20090511] +synonym: "Schaffer collateral" BROAD [NIF_Subcellular:sao1950673097] +xref: NIF_Subcellular:nlx_subcell_20090511 +is_a: GO:0044303 ! axon collateral + +[Term] +id: GO:1990022 +name: obsolete RNA polymerase III complex import into nucleus +namespace: biological_process +def: "OBSOLETE. The directed movement of an RNA polymerase III complex from the cytoplasm to the nucleus." [GOC:mcc, PMID:23267056] +comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. +synonym: "DNA-directed RNA polymerase III complex import into nucleus" EXACT [] +synonym: "DNA-directed RNA polymerase III complex localization to nucleus" EXACT [] +synonym: "RNA polymerase III complex import into nucleus" EXACT [] +synonym: "RNA polymerase III complex localisation to nucleus" EXACT [] +synonym: "RNA polymerase III complex localization to nucleus" RELATED [] +is_obsolete: true +consider: GO:0006606 + +[Term] +id: GO:1990023 +name: mitotic spindle midzone +namespace: cellular_component +def: "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw] +is_a: GO:0051233 ! spindle midzone +relationship: part_of GO:0072686 ! mitotic spindle + +[Term] +id: GO:1990024 +name: C bouton +namespace: cellular_component +def: "Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons." [NIF_Subcellular:nlx_subcell_100208] +xref: NIF_Subcellular:nlx_subcell_100208 +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:1990025 +name: F bouton +namespace: cellular_component +def: "Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles." [NIF_Subcellular:nlx_subcell_100206] +xref: NIF_Subcellular:nlx_subcell_100206 +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:1990026 +name: hippocampal mossy fiber expansion +namespace: cellular_component +def: "Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites." [NIF_Subcellular:nlx_subcell_1005002] +synonym: "dentate gyrus granule cell axonal bouton" RELATED [] +synonym: "dentate gyrus mossy fiber expansion" RELATED [] +synonym: "mossy fiber expansion" BROAD [] +xref: NIF_Subcellular:nlx_subcell_1005002 +is_a: GO:0043195 ! terminal bouton +relationship: part_of GO:0097457 ! hippocampal mossy fiber + +[Term] +id: GO:1990027 +name: S bouton +namespace: cellular_component +def: "Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles." [NIF_Subcellular:nlx_subcell_100207] +xref: NIF_Subcellular:nlx_subcell_100207 +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:1990028 +name: intermediate voltage-gated calcium channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded." [GOC:BHF, GOC:rl, PMID:16382099, Wikipedia:Calcium_channel] +synonym: "R-type calcium channel" RELATED [] +is_a: GO:0005245 ! voltage-gated calcium channel activity + +[Term] +id: GO:1990029 +name: vasomotion +namespace: biological_process +def: "The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm." [GOC:sl, PMID:14993429, PMID:15678091, PMID:1932763] +is_a: GO:0003013 ! circulatory system process + +[Term] +id: GO:1990030 +name: pericellular basket +namespace: cellular_component +def: "Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name." [NIF_Subcellular:sao413722576] +synonym: "peri cellular basket" EXACT [] +synonym: "peri-cellular basket" EXACT [] +xref: NIF_Subcellular:sao413722576 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:1990031 +name: pinceau fiber +namespace: cellular_component +def: "Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment." [NIF_Subcellular:sao109906988] +xref: NIF_Subcellular:sao109906988 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0030424 ! axon + +[Term] +id: GO:1990032 +name: parallel fiber +namespace: cellular_component +def: "A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium." [ISBN:0195159551, NIF_Subcellular:nlx_330] +xref: NIF_Subcellular:nlx_330 +is_a: GO:0030424 ! axon + +[Term] +id: GO:1990033 +name: dendritic branch point +namespace: cellular_component +def: "The part of a dendritic tree where it branches, giving rise to a dendritic branch." [GOC:aruk, GOC:bc, NIF_Subcellular:sao1348591767] +synonym: "branch point of dendrite" EXACT [] +xref: NIF_Subcellular:sao1348591767 +is_a: GO:0061845 ! neuron projection branch point +relationship: part_of GO:0097447 ! dendritic tree + +[Term] +id: GO:1990034 +name: calcium ion export across plasma membrane +namespace: biological_process +def: "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:2145281] +synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281] +synonym: "calcium ion export from cell" EXACT [] +is_a: GO:0060401 ! cytosolic calcium ion transport +is_a: GO:0070588 ! calcium ion transmembrane transport +is_a: GO:0140115 ! export across plasma membrane +is_a: GO:1901660 ! calcium ion export + +[Term] +id: GO:1990036 +name: calcium ion import into sarcoplasmic reticulum +namespace: biological_process +def: "The directed movement of calcium ions into a sarcoplasmic reticulum." [GOC:BHF, PMID:17286271] +is_a: GO:0046907 ! intracellular transport +is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport +is_a: GO:0070509 ! calcium ion import + +[Term] +id: GO:1990037 +name: Lewy body core +namespace: cellular_component +def: "The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments." [NIF_Subcellular:sao6587439252] +xref: NIF_Subcellular:sao6587439252 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097413 ! Lewy body + +[Term] +id: GO:1990038 +name: Lewy body corona +namespace: cellular_component +def: "The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array." [NIF_Subcellular:sao5764355747] +synonym: "halo" BROAD [] +xref: NIF_Subcellular:sao5764355747 +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0097413 ! Lewy body + +[Term] +id: GO:1990039 +name: hypolemmal cisterna +namespace: cellular_component +def: "Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer." [ISBN:0195065719, NIF_Subcellular:sao1634374950] +synonym: "hypolemmal cisternae" EXACT [] +xref: NIF_Subcellular:sao1634374950 +is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna + +[Term] +id: GO:1990040 +name: sub-surface cisterna +namespace: cellular_component +def: "Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane." [ISBN:0195065719, NIF_Subcellular:sao128470897] +synonym: "sub-surface cisternae" EXACT [] +xref: NIF_Subcellular:sao128470897 +is_a: GO:1990039 ! hypolemmal cisterna + +[Term] +id: GO:1990042 +name: glycerol dehydrogenase [NAD(P)+] activity +namespace: molecular_function +def: "Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced." [PMID:22979944] +synonym: "glycerol dehydrogenase activity, NAD or NADP as acceptor" EXACT [] +is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor + +[Term] +id: GO:1990043 +name: 5' deoxyribonuclease (pyrimidine dimer) activity +namespace: molecular_function +def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997] +is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity + +[Term] +id: GO:1990044 +name: protein localization to lipid droplet +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet." [GOC:sart, PMID:22505614] +synonym: "protein localisation to adiposome" EXACT [] +synonym: "protein localisation to lipid body" EXACT [] +synonym: "protein localisation to lipid droplet" EXACT [] +synonym: "protein localisation to lipid particle" EXACT [] +synonym: "protein localization to adiposome" EXACT [] +synonym: "protein localization to lipid body" EXACT [] +synonym: "protein localization to lipid particle" EXACT [] +is_a: GO:0033365 ! protein localization to organelle + +[Term] +id: GO:1990045 +name: sclerotium development +namespace: biological_process +def: "The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions." [GOC:di, PMID:21148914] +is_a: GO:0048856 ! anatomical structure development + +[Term] +id: GO:1990046 +name: stress-induced mitochondrial fusion +namespace: biological_process +def: "Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis." [GOC:lb, PMID:19360003] +synonym: "mitochondrial fusion in response to stress" RELATED [] +synonym: "SIMH" NARROW [] +synonym: "stress-induced mitochondrial hyperfusion" NARROW [] +is_a: GO:0008053 ! mitochondrial fusion +is_a: GO:0033554 ! cellular response to stress + +[Term] +id: GO:1990047 +name: spindle matrix +namespace: cellular_component +def: "A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis." [GOC:ans, PMID:19273613, PMID:22855526] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005856 ! cytoskeleton + +[Term] +id: GO:1990048 +name: anterograde neuronal dense core vesicle transport +namespace: biological_process +def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451] +subset: goslim_synapse +synonym: "anterograde dense core granule trafficking" EXACT [] +synonym: "anterograde dense core granule transport" EXACT [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0099519 ! dense core granule cytoskeletal transport + +[Term] +id: GO:1990049 +name: retrograde neuronal dense core vesicle transport +namespace: biological_process +def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653] +subset: goslim_synapse +synonym: "retrograde dense core granule trafficking" EXACT [] +synonym: "retrograde dense core granule transport" EXACT [] +is_a: GO:0008090 ! retrograde axonal transport +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0099519 ! dense core granule cytoskeletal transport + +[Term] +id: GO:1990050 +name: phosphatidic acid transfer activity +namespace: molecular_function +def: "Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3." [PMID:23042293] +synonym: "intermembrane PA transfer activity" EXACT [] +synonym: "intermembrane phosphatidic acid transfer activity" NARROW [] +synonym: "phosphatidic acid carrier activity" EXACT [] +synonym: "phosphatidic acid transporter activity" BROAD [] +is_a: GO:0120014 ! phospholipid transfer activity + +[Term] +id: GO:1990051 +name: activation of protein kinase C activity +namespace: biological_process +def: "Any process that initiates the activity of the inactive enzyme protein kinase C." [PMID:3156004] +synonym: "PKC activation" EXACT [] +synonym: "protein kinase C activation" EXACT [] +is_a: GO:0032147 ! activation of protein kinase activity + +[Term] +id: GO:1990052 +name: ER to chloroplast lipid transport +namespace: biological_process +def: "The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast." [PMID:18689504] +synonym: "endoplasmic reticulum to chloroplast lipid transport" EXACT [] +synonym: "ER to chloroplast lipid trafficking" EXACT [] +is_a: GO:0032365 ! intracellular lipid transport +is_a: GO:1901965 ! endoplasmic reticulum to chloroplast transport + +[Term] +id: GO:1990053 +name: DNA-5-methylcytosine glycosylase activity +namespace: molecular_function +def: "Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site." [PMID:23316050] +is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity + +[Term] +id: GO:1990054 +name: response to temozolomide +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus." [GOC:hp] +comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. +subset: gocheck_do_not_manually_annotate +is_a: GO:0010243 ! response to organonitrogen compound +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901700 ! response to oxygen-containing compound + +[Term] +id: GO:1990055 +name: phenylacetaldehyde synthase activity +namespace: molecular_function +def: "Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2." [MetaCyc:RXN-8990, PMID:16766535, PMID:23204519] +synonym: "aromatic aldehyde synthase" BROAD [] +xref: EC:4.1.1.109 +xref: RHEA:55532 +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:1990056 +name: obsolete protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process +namespace: molecular_function +def: "OBSOLETE. Catalysis of the phosphorylation of an amino acid residue in a substrate protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP, thereby targeting the substrate to the proteasomal ubiquitin mediated protein catabolic process." [PMID:21098119, PMID:21993622, PMID:23264631] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "protein kinase activity required for targeting substrate to proteasomal ubiquitin-dependent protein catabolic process" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990057 +name: obsolete cell cycle arrest in response to DNA damage stimulus +namespace: biological_process +def: "OBSOLETE. The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of DNA damage from environmental insults or errors during metabolism." [GOC:rph, PMID:10630641] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "cell cycle arrest in response to DNA damage stimulus" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990058 +name: fruit replum development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum." [PMID:23133401, PO:0025267] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:1990059 +name: fruit valve development +namespace: biological_process +def: "The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces." [PMID:23133401, PO:0000033] +is_a: GO:0003006 ! developmental process involved in reproduction +is_a: GO:0009791 ! post-embryonic development +is_a: GO:0048856 ! anatomical structure development +relationship: part_of GO:0010154 ! fruit development + +[Term] +id: GO:1990060 +name: maltose transport complex +namespace: cellular_component +def: "Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK." [PMID:18033289] +synonym: "maltose ABC transporter complex" EXACT [] +synonym: "maltose ATP-binding cassette transporter complex" EXACT [] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990061 +name: bacterial degradosome +namespace: cellular_component +def: "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase." [GOC:bhm, PMID:21805185] +is_a: GO:0000177 ! cytoplasmic exosome (RNase complex) +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990062 +name: RPAP3/R2TP/prefoldin-like complex +namespace: cellular_component +def: "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity." [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846] +synonym: "R2TP/prefoldin-like complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990063 +name: Bam protein complex +namespace: cellular_component +def: "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex." [GOC:bhm, PMID:20378773] +synonym: "OMP complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0031246 ! intrinsic component of periplasmic side of cell outer membrane + +[Term] +id: GO:1990064 +name: ground tissue pattern formation +namespace: biological_process +def: "The regionalization process that gives rise to the patterning of the ground tissue." [PMID:23444357] +synonym: "ground tissue patterning" EXACT [] +is_a: GO:0003002 ! regionalization + +[Term] +id: GO:1990065 +name: Dxr protein complex +namespace: cellular_component +def: "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)." [GOC:bhm, PMID:15339150] +synonym: "1-deoxy-D-xylulose 5-phosphate reductoisomerase complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990066 +name: energy quenching +namespace: biological_process +def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence." [PMID:10938857] +is_a: GO:0009416 ! response to light stimulus + +[Term] +id: GO:1990067 +name: intrachromosomal DNA recombination +namespace: biological_process +def: "The process of DNA recombination occurring within a single chromosome." [PMID:7748165] +synonym: "intrastrand DNA recombination" EXACT [] +is_a: GO:0006310 ! DNA recombination + +[Term] +id: GO:1990068 +name: seed dehydration +namespace: biological_process +def: "The seed development process whose outcome is the drying of a maturing seed." [PMID:20138563] +is_a: GO:0048609 ! multicellular organismal reproductive process +relationship: part_of GO:0010431 ! seed maturation + +[Term] +id: GO:1990069 +name: stomatal opening +namespace: biological_process +def: "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [PMID:21749899] +is_a: GO:0010118 ! stomatal movement + +[Term] +id: GO:1990070 +name: TRAPPI protein complex +namespace: cellular_component +def: "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast." [GOC:bhm, PMID:20375281, PMID:22669257] +synonym: "TRAPP core complex" EXACT [] +is_a: GO:0030008 ! TRAPP complex +relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment + +[Term] +id: GO:1990071 +name: TRAPPII protein complex +namespace: cellular_component +def: "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257] +is_a: GO:0030008 ! TRAPP complex +relationship: part_of GO:0005768 ! endosome +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:1990072 +name: TRAPPIII protein complex +namespace: cellular_component +def: "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257] +is_a: GO:0030008 ! TRAPP complex +relationship: part_of GO:0005794 ! Golgi apparatus + +[Term] +id: GO:1990073 +name: perforation plate +namespace: cellular_component +def: "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations)." [GOC:PO_curators, ISBN:0471245194] +comment: Part of a vessel member (PO:0002003). May be simple, with one perforation, or multiperforate, with more than one perforation. Perforation plates are usually on the end walls of a cell, but may also be on the side walls. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005618 ! cell wall + +[Term] +id: GO:1990074 +name: polyuridylation-dependent mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588] +is_a: GO:0006402 ! mRNA catabolic process +is_a: GO:0043632 ! modification-dependent macromolecule catabolic process +is_a: GO:0061157 ! mRNA destabilization + +[Term] +id: GO:1990075 +name: periciliary membrane compartment +namespace: cellular_component +def: "A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis." [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749] +synonym: "PCMC" EXACT [] +is_a: GO:0098590 ! plasma membrane region + +[Term] +id: GO:1990076 +name: cell wall polysaccharide catabolic process involved in abscission +namespace: biological_process +def: "Any cell wall polysaccharide catabolic process that is involved in abscission." [GOC:TermGenie, PMID:23479623] +is_a: GO:0044347 ! cell wall polysaccharide catabolic process +relationship: part_of GO:0009838 ! abscission + +[Term] +id: GO:1990077 +name: primosome complex +namespace: cellular_component +def: "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207] +synonym: "primosome" EXACT [] +is_a: GO:0032993 ! protein-DNA complex +relationship: part_of GO:0030894 ! replisome + +[Term] +id: GO:1990078 +name: replication inhibiting complex +namespace: cellular_component +def: "A protein complex that inhibits multiple events of replication initiation during one replication cycle." [GOC:bhm, PMID:21708944] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030894 ! replisome + +[Term] +id: GO:1990079 +name: cartilage homeostasis +namespace: biological_process +alt_id: GO:1902094 +alt_id: GO:1902095 +alt_id: GO:1902096 +def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695] +synonym: "negative regulation of cartilage homeostasis" RELATED [] +synonym: "positive regulation of cartilage homeostasis" RELATED [] +synonym: "regulation of cartilage homeostasis" RELATED [] +is_a: GO:0001894 ! tissue homeostasis + +[Term] +id: GO:1990080 +name: 2-phenylethylamine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity." [PMID:16878137] +synonym: "beta-phenylethylamine receptor activity" EXACT [] +is_a: GO:0008227 ! G protein-coupled amine receptor activity + +[Term] +id: GO:1990081 +name: trimethylamine receptor activity +namespace: molecular_function +def: "Combining with the biogenic amine trimethylamine to initiate a change in cell activity." [PMID:16878137] +is_a: GO:0001594 ! trace-amine receptor activity + +[Term] +id: GO:1990082 +name: DnaA-L2 complex +namespace: cellular_component +def: "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2." [GOC:bhm, PMID:21288885] +is_a: GO:1990078 ! replication inhibiting complex + +[Term] +id: GO:1990083 +name: DnaA-Hda complex +namespace: cellular_component +def: "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda." [GOC:bhm, PMID:21708944] +is_a: GO:1990078 ! replication inhibiting complex + +[Term] +id: GO:1990084 +name: DnaA-Dps complex +namespace: cellular_component +def: "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps." [GOC:bhm, PMID:18284581] +is_a: GO:1990078 ! replication inhibiting complex + +[Term] +id: GO:1990085 +name: Hda-beta clamp complex +namespace: cellular_component +def: "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda." [GOC:bhm, PMID:15150238] +synonym: "Hda-DnaN complex" EXACT [] +synonym: "Hda-dpo3b complex" EXACT [] +is_a: GO:1990078 ! replication inhibiting complex + +[Term] +id: GO:1990086 +name: lens fiber cell apoptotic process +namespace: biological_process +def: "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619] +is_a: GO:1904019 ! epithelial cell apoptotic process + +[Term] +id: GO:1990088 +name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase +namespace: molecular_function +alt_id: GO:0043851 +def: "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-coenzyme M + a [Co(I) methanol-specific corrinoid protein] + H+." [GOC:hjd, PMID:10077852, RHEA:45208] +comment: This function is the second step in the pathway of methanogenesis from methanol. +synonym: "methanol-specific methylcobalamin: coenzyme M methyltransferase activity" EXACT [] +synonym: "methanol-specific methylcobalamin:coenzyme M methyltransferase activity" EXACT [] +synonym: "methanol-specific methylcobalamin:CoM methyltransferase activity" EXACT [] +synonym: "methylcobamide:coenzyme M methyltransferase activity" BROAD [] +synonym: "methylcobamide:CoM methyltransferase activity" BROAD [] +xref: EC:2.1.1.246 +xref: MetaCyc:RXN-8096 +xref: RHEA:45208 +is_a: GO:0008168 ! methyltransferase activity + +[Term] +id: GO:1990089 +name: response to nerve growth factor +namespace: biological_process +def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805] +synonym: "response to nerve growth factor stimulus" EXACT [GOC:dos] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:1990090 +name: cellular response to nerve growth factor stimulus +namespace: biological_process +def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805, Wikipedia:Nerve_growth_factor] +synonym: "cellular response to NGF" EXACT [GOC:bf, Wikipedia:Nerve_growth_factor] +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:1990089 ! response to nerve growth factor + +[Term] +id: GO:1990091 +name: sodium-dependent self proteolysis +namespace: biological_process +def: "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380] +is_a: GO:0097264 ! self proteolysis + +[Term] +id: GO:1990092 +name: calcium-dependent self proteolysis +namespace: biological_process +def: "The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380] +is_a: GO:0097264 ! self proteolysis + +[Term] +id: GO:1990093 +name: obsolete negative regulation of N-methyl-D-aspartate receptor clustering +namespace: biological_process +def: "OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "negative regulation of N-methyl-D-aspartate receptor clustering" EXACT [] +synonym: "negative regulation of NMDA receptor clustering" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990094 +name: obsolete positive regulation of N-methyl-D-aspartate receptor clustering +namespace: biological_process +def: "OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "positive regulation of N-methyl-D-aspartate receptor clustering" EXACT [] +synonym: "positive regulation of NMDA receptor clustering" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990095 +name: positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:kmv, PMID:16166371] +is_a: GO:0036091 ! positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress +relationship: part_of GO:0034614 ! cellular response to reactive oxygen species + +[Term] +id: GO:1990096 +name: positive regulation of transcription from RNA polymerase II promoter in response to superoxide +namespace: biological_process +def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:kmv, PMID:12869585, PMID:16166371] +is_a: GO:1990095 ! positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species +relationship: part_of GO:0071451 ! cellular response to superoxide + +[Term] +id: GO:1990097 +name: SeqA-DNA complex +namespace: cellular_component +def: "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle." [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570] +synonym: "SeqA-dsDNA complex" NARROW [] +synonym: "SeqA-hemimethylated DNA complex" NARROW [] +synonym: "SeqA-hemimethylation dsDNA complex" NARROW [] +is_a: GO:0032993 ! protein-DNA complex + +[Term] +id: GO:1990098 +name: core primosome complex +namespace: cellular_component +def: "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication." [GOC:bhm, PMID:21856207] +comment: The core primosome refers to a helicase-primase complex, and should not be confused with the more general GO term 'primosome complex ; GO:1990077'. +synonym: "core primosome" EXACT [GOC:bhm] +is_a: GO:1990077 ! primosome complex + +[Term] +id: GO:1990099 +name: pre-primosome complex +namespace: cellular_component +def: "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component." [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105] +synonym: "pre-priming complex" EXACT [GOC:bhm] +synonym: "pre-primosome" EXACT [GOC:bhm, PMID:11994158] +synonym: "pre-replication complex" RELATED [GOC:bhm] +synonym: "preprimosome" EXACT [GOC:bhm, PMID:2824502] +synonym: "preprimosome complex" EXACT [GOC:bhm] +synonym: "prereplication complex" EXACT [GOC:bhm] +is_a: GO:1990077 ! primosome complex + +[Term] +id: GO:1990100 +name: DnaB-DnaC complex +namespace: cellular_component +def: "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC)." [GOC:bhm, PMID:20129058] +comment: DnaB and DnaC may be present in different ratios in different forms of the DnaB-DnaC complex, including a DnaB6-DnaC3 complex active at the oriC, and a DnaB6-DnaC6 complex. +synonym: "DnaB6-DnaC3 complex" NARROW [PMID:20129058] +synonym: "DnaB6-DnaC6 complex" NARROW [PMID:20129058] +synonym: "helicase-loading complex" BROAD [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:1990077 ! primosome complex + +[Term] +id: GO:1990101 +name: DnaA-oriC complex +namespace: cellular_component +def: "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle." [GOC:bhm, PMID:19833870] +synonym: "DnaA-DNA complex" BROAD [GOC:bhm] +is_a: GO:1990077 ! primosome complex + +[Term] +id: GO:1990102 +name: DnaA-DiaA complex +namespace: cellular_component +def: "A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA." [GOC:bhm, PMID:15326179, PMID:17699754] +synonym: "DnaA-DiaA-DNA complex" EXACT [GOC:bhm] +is_a: GO:1990077 ! primosome complex + +[Term] +id: GO:1990103 +name: DnaA-HU complex +namespace: cellular_component +def: "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC." [GOC:bhm, PMID:18179598] +synonym: "DnaA-HU-DNA complex" EXACT [GOC:bhm] +is_a: GO:1990077 ! primosome complex + +[Term] +id: GO:1990104 +name: DNA bending complex +namespace: cellular_component +def: "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674] +synonym: "histone-like DNA binding complex" NARROW [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990105 +name: obsolete regulation of voltage-gated potassium channel activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity." [PMID:19219384] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of voltage-gated potassium channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990107 +name: thiazole synthase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O." [EC:2.8.1.10, GOC:cjk, PMID:22031445, RHEA:26297] +comment: H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis. +synonym: "1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity" EXACT [] +xref: RHEA:26297 +is_a: GO:0016783 ! sulfurtransferase activity + +[Term] +id: GO:1990108 +name: protein linear deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein." [PMID:23708998] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:1990109 +name: rejection of pollen from other species +namespace: biological_process +def: "The process involved in the rejection of pollen of one species by cells in the stigma of another species." [PMID:21205670] +synonym: "unilateral interspecific incompatibility" EXACT [] +is_a: GO:0022414 ! reproductive process +is_a: GO:0044419 ! biological process involved in interspecies interaction between organisms +relationship: part_of GO:0009875 ! pollen-pistil interaction + +[Term] +id: GO:1990110 +name: callus formation +namespace: biological_process +def: "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517] +is_a: GO:0032501 ! multicellular organismal process +relationship: part_of GO:0042060 ! wound healing + +[Term] +id: GO:1990111 +name: spermatoproteasome complex +namespace: cellular_component +def: "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." [GOC:sp, PMID:23706739] +is_a: GO:0000502 ! proteasome complex + +[Term] +id: GO:1990112 +name: RQC complex +namespace: cellular_component +def: "A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563] +synonym: "ribosome quality control complex" EXACT [PMID:23178123, PMID:23232563] +synonym: "ribosome-bound quality control complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990113 +name: RNA polymerase I assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex." [GOC:rb, PMID:23459708] +synonym: "DNA-directed RNA polymerase I complex assembly" EXACT [] +synonym: "RNA Polymerase I complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1990114 +name: RNA polymerase II core complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." [GOC:rb, PMID:23459708] +synonym: "DNA-directed RNA polymerase II, core complex assembly" EXACT [] +synonym: "RNA Polymerase II assembly" BROAD [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1990115 +name: RNA polymerase III assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708] +synonym: "DNA-directed RNA polymerase III complex assembly" EXACT [] +synonym: "RNA Polymerase III complex assembly" EXACT [] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1990116 +name: ribosome-associated ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411] +synonym: "RAD" BROAD [] +synonym: "ribosome-associated degradation" BROAD [] +synonym: "ribosome-associated ubiquitin-dependent protein breakdown" EXACT [] +synonym: "ribosome-associated ubiquitin-dependent protein catabolism" EXACT [] +synonym: "ribosome-associated ubiquitin-dependent protein degradation" EXACT [] +is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process + +[Term] +id: GO:1990117 +name: B cell receptor apoptotic signaling pathway +namespace: biological_process +def: "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043] +synonym: "B cell receptor extrinsic apoptotic signaling pathway" EXACT [] +synonym: "extrinsic apoptotic signaling pathway via B cell antigen receptor" RELATED [] +synonym: "extrinsic apoptotic signaling pathway via BCR" RELATED [] +is_a: GO:0050853 ! B cell receptor signaling pathway +is_a: GO:0097191 ! extrinsic apoptotic signaling pathway +relationship: part_of GO:0001783 ! B cell apoptotic process + +[Term] +id: GO:1990119 +name: RNA helicase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of an RNA helicase." [GOC:rb, PMID:23721653] +synonym: "ATP-dependent RNA helicase inhibitor activity" EXACT [] +is_a: GO:0004857 ! enzyme inhibitor activity +is_a: GO:0042030 ! ATPase inhibitor activity + +[Term] +id: GO:1990120 +name: messenger ribonucleoprotein complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653] +synonym: "messenger ribonucleoprotein assembly" RELATED [] +synonym: "mRNA-protein complex assembly" EXACT [GOC:bf] +synonym: "mRNP assembly" EXACT [GOC:rb] +synonym: "mRNP complex assembly" EXACT [GOC:bf] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:1990121 +name: H-NS complex +namespace: cellular_component +def: "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA." [GOC:bhm, PMID:12592399] +synonym: "DNA-binding protein H-NS complex" EXACT [] +synonym: "histone-like protein H-NS complex" EXACT [] +is_a: GO:1990104 ! DNA bending complex +relationship: part_of GO:0005829 ! cytosol +relationship: part_of GO:0043590 ! bacterial nucleoid + +[Term] +id: GO:1990124 +name: messenger ribonucleoprotein complex +namespace: cellular_component +def: "A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786] +synonym: "messenger ribonucleoprotein particle" RELATED [PMID:21915786] +synonym: "mRNA-protein complex" EXACT [PMID:21915786] +synonym: "mRNP" EXACT [PMID:21915786] +synonym: "mRNP complex" EXACT [PMID:15574591, PMID:21915786] +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:1990125 +name: DiaA complex +namespace: cellular_component +def: "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation." [GOC:bhm, PMID:17699754] +synonym: "DiaA homotetramer" EXACT [GOC:bf, PMID:17699754] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990127 +name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered." [GOC:krc, GOC:mtg_apoptosis, PMID:16571598] +is_a: GO:0008627 ! intrinsic apoptotic signaling pathway in response to osmotic stress +is_a: GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator + +[Term] +id: GO:1990128 +name: obsolete pre-primosome complex involved in replication initiation +namespace: cellular_component +def: "OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication." [GOC:bhm, PMID:21856207] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "pre-primosome complex involved in replication initiation" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990129 +name: obsolete pre-primosome complex involved in replication restart +namespace: cellular_component +def: "OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired." [GOC:bhm, PMID:17139333] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "pre-primosome complex involved in replication restart" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990130 +name: GATOR1 complex +namespace: cellular_component +def: "A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins." [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950] +comment: The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. +synonym: "IML1 complex" EXACT [] +synonym: "SEACIT complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0035859 ! Seh1-associated complex + +[Term] +id: GO:1990131 +name: Gtr1-Gtr2 GTPase complex +namespace: cellular_component +def: "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990132 +name: obsolete release of misfolded protein from chaperone +namespace: biological_process +def: "OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery." [GOC:rb, PMID:23530227] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "release of misfolded protein from chaperone" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990133 +name: molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex +namespace: cellular_component +def: "A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, pmid:11713534, pmid:16669776] +is_a: GO:1902503 ! adenylyltransferase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990134 +name: epithelial cell apoptotic process involved in palatal shelf morphogenesis +namespace: biological_process +def: "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf." [GOC:dph, GOC:mtg_apoptosis, PMID:16607638] +is_a: GO:0060561 ! apoptotic process involved in morphogenesis +is_a: GO:1904019 ! epithelial cell apoptotic process +relationship: part_of GO:0062009 ! secondary palate development + +[Term] +id: GO:1990135 +name: flavonoid sulfotransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative." [PMID:23611783] +is_a: GO:0008146 ! sulfotransferase activity + +[Term] +id: GO:1990136 +name: linoleate 9S-lipoxygenase activity +namespace: molecular_function +def: "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate." [GOC:rph, RHEA:30291] +synonym: "9-lipoxygenase activity" RELATED [] +synonym: "9S-lipoxygenase activity" RELATED [] +synonym: "linoleate 9-lipoxygenase activity" RELATED [] +synonym: "linoleate:oxygen 9S-oxidoreductase activity" EXACT [] +xref: EC:1.13.11.58 +xref: RHEA:30291 +is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen + +[Term] +id: GO:1990137 +name: plant seed peroxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH." [PMID:19467604] +synonym: "peroxygenase activity" RELATED [PMID:19467604] +xref: EC:1.11.2.3 +xref: MetaCyc:RXN-11819 +is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor + +[Term] +id: GO:1990138 +name: neuron projection extension +namespace: biological_process +def: "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009] +synonym: "neurite extension" NARROW [] +synonym: "neuron process extension" EXACT [] +synonym: "neuron protrusion extension" EXACT [] +synonym: "neuronal cell projection extension" EXACT [] +is_a: GO:0048588 ! developmental cell growth +is_a: GO:0060560 ! developmental growth involved in morphogenesis +relationship: part_of GO:0048812 ! neuron projection morphogenesis + +[Term] +id: GO:1990139 +name: protein localization to nuclear periphery +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609] +is_a: GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1990140 +name: MPT synthase complex +namespace: cellular_component +def: "A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11135669, PMID:16669776, Reactome:R-HSA-947581] +synonym: "molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex" RELATED [] +is_a: GO:1990228 ! sulfurtransferase complex + +[Term] +id: GO:1990142 +name: envenomation resulting in hemolysis in another organism +namespace: biological_process +def: "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism." [PMID:21590705] +synonym: "envenomation resulting in hemolysis in other organism" EXACT [] +is_a: GO:0044649 ! envenomation resulting in cytolysis in another organism + +[Term] +id: GO:1990143 +name: CoA-synthesizing protein complex +namespace: cellular_component +def: "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway." [GOC:rb, PMID:23789928] +synonym: "CoA-SPC" EXACT [] +synonym: "coenzyme A-synthesizing protein complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990144 +name: intrinsic apoptotic signaling pathway in response to hypoxia +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456] +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway +relationship: part_of GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:1990145 +name: maintenance of translational fidelity +namespace: biological_process +def: "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template." [GOC:hjd, ISBN:9781936113460, PMID:21841312] +is_a: GO:0009059 ! macromolecule biosynthetic process +relationship: part_of GO:0006412 ! translation + +[Term] +id: GO:1990146 +name: protein localization to rhabdomere +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:1990147 +name: talin binding +namespace: molecular_function +def: "Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types." [GOC:hjd, PMID:23372168] +is_a: GO:0008092 ! cytoskeletal protein binding + +[Term] +id: GO:1990148 +name: glutamate dehydrogenase complex +namespace: cellular_component +def: "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies." [GOC:bhm, PMID:22393408, PMID:23412807] +synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)) complex" RELATED [] +synonym: "glutamate dehydrogenase (NADP+) complex" RELATED [] +synonym: "glutamic acid dehydrogenase complex" RELATED [] +synonym: "glutamic dehydrogenase complex" RELATED [] +synonym: "L-glutamate dehydrogenase complex" RELATED [] +synonym: "L-glutamate:NADP+ oxidoreductase (deaminating) complex" RELATED [] +synonym: "L-glutamic acid dehydrogenase complex" RELATED [] +synonym: "NAD(P)-glutamate dehydrogenase complex" RELATED [] +synonym: "NAD(P)H-dependent glutamate dehydrogenase complex" RELATED [] +is_a: GO:1990204 ! oxidoreductase complex + +[Term] +id: GO:1990149 +name: obsolete COPI vesicle coating +namespace: biological_process +def: "OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:rb, PMID:11970962] +comment: This term was obsoleted at the TermGenie Gatekeeper stage because COPI vesicles are formed on Golgi membranes, and the existing term 'COPI coating of Golgi vesicle ; GO:0048205' describes this process. +synonym: "COPI vesicle coating" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990150 +name: VEGF-A complex +namespace: cellular_component +def: "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase." [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168] +synonym: "vascular endothelial growth factor A complex" EXACT [GOC:bhm] +is_a: GO:0036454 ! growth factor complex + +[Term] +id: GO:1990151 +name: protein localization to cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263] +synonym: "protein localisation to cell tip" EXACT [GOC:mah] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:1990153 +name: maintenance of protein localization to heterochromatin +namespace: biological_process +def: "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781] +synonym: "maintenance of protein localisation to heterochromatin" EXACT [GOC:mah] +synonym: "maintenance of protein location in heterochromatin" RELATED [GOC:mah] +is_a: GO:0032507 ! maintenance of protein location in cell +relationship: part_of GO:0097355 ! protein localization to heterochromatin + +[Term] +id: GO:1990154 +name: enzyme IIA-maltose transporter complex +namespace: cellular_component +def: "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter." [GOC:bf, GOC:bhm, PMID:23770568] +synonym: "EIIA(Glc)-MalFGK2 complex" EXACT [PMID:23770568] +synonym: "EIIA(Glc)-maltose transporter complex" EXACT [PMID:23770568] +synonym: "maltose transporter inhibitor complex" RELATED [GOC:bhm] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990155 +name: Dsc E3 ubiquitin ligase complex assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507] +synonym: "Dsc complex assembly" EXACT [PMID:23760507] +is_a: GO:0065003 ! protein-containing complex assembly + +[Term] +id: GO:1990156 +name: DnaB-DnaG complex +namespace: cellular_component +def: "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes." [GOC:bhm, PMID:14557266] +synonym: "DnaB-DnaG primosome complex" RELATED [GOC:bhm] +is_a: GO:0033202 ! DNA helicase complex +relationship: part_of GO:1990098 ! core primosome complex + +[Term] +id: GO:1990157 +name: DnaA-DnaB-DnaC complex +namespace: cellular_component +def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation." [GOC:bhm, PMID:20129058] +is_a: GO:1990099 ! pre-primosome complex + +[Term] +id: GO:1990158 +name: DnaB-DnaC-DnaT-PriA-PriB complex +namespace: cellular_component +def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105] +synonym: "DnaB-DnaC-DnaT-PriA-PriB preprimosome" EXACT [PMID:8663105] +synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] +is_a: GO:1990099 ! pre-primosome complex + +[Term] +id: GO:1990159 +name: DnaB-DnaC-DnaT-PriA-PriC complex +namespace: cellular_component +def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105] +synonym: "DnaB-DnaC-DnaT-PriA-PriC preprimosome" EXACT [PMID:8663105] +synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] +is_a: GO:1990099 ! pre-primosome complex + +[Term] +id: GO:1990160 +name: DnaB-DnaC-Rep-PriC complex +namespace: cellular_component +def: "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:19941825, PMID:8663105] +synonym: "DnaB-DnaC-Rep-PriC preprimosome" EXACT [PMID:8663105] +synonym: "phi-X174-type preprimosome" RELATED [PMID:8663105] +is_a: GO:1990099 ! pre-primosome complex + +[Term] +id: GO:1990161 +name: DnaB helicase complex +namespace: cellular_component +def: "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair." [GOC:bhm, PMID:17947583] +synonym: "DnaB hexamer" EXACT [GOC:bhm] +is_a: GO:0033202 ! DNA helicase complex + +[Term] +id: GO:1990162 +name: histone deacetylase activity (H3-K4 specific) +namespace: molecular_function +def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein." [GOC:al, PMID:23771057, PMID:28450737] +is_a: GO:0004407 ! histone deacetylase activity + +[Term] +id: GO:1990164 +name: histone H2A phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121] +is_a: GO:0016572 ! histone phosphorylation + +[Term] +id: GO:1990165 +name: single-strand break-containing DNA binding +namespace: molecular_function +def: "Binding to damaged DNA containing single-strand breaks (SSBs)." [GOC:al, PMID:21984210] +synonym: "single-strand break-containing damaged DNA binding" EXACT [] +synonym: "SSB-containing DNA binding" EXACT [] +is_a: GO:0003684 ! damaged DNA binding + +[Term] +id: GO:1990166 +name: protein localization to site of double-strand break +namespace: biological_process +def: "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121] +synonym: "protein localisation to site of double-strand break" EXACT [GOC:mah] +synonym: "protein localization to double-strand break site" EXACT [GOC:mah] +synonym: "protein localization to site of DSB" EXACT [GOC:mah] +is_a: GO:0034502 ! protein localization to chromosome + +[Term] +id: GO:1990167 +name: protein K27-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein." [PMID:23827681] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:1990168 +name: protein K33-linked deubiquitination +namespace: biological_process +def: "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681] +is_a: GO:0016579 ! protein deubiquitination + +[Term] +id: GO:1990169 +name: stress response to copper ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus." [GOC:kmv, PMID:23437011] +synonym: "response to copper ion stress" EXACT [] +synonym: "response to copper toxicity" RELATED [] +synonym: "stress response to copper" BROAD [] +is_a: GO:0046688 ! response to copper ion +is_a: GO:0097501 ! stress response to metal ion + +[Term] +id: GO:1990170 +name: stress response to cadmium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus." [GOC:kmv] +synonym: "response to cadmium ion stress" EXACT [] +synonym: "response to cadmium toxicity" RELATED [] +synonym: "stress response to cadmium" BROAD [] +is_a: GO:0046686 ! response to cadmium ion +is_a: GO:0097501 ! stress response to metal ion + +[Term] +id: GO:1990171 +name: SCF complex disassembly in response to cadmium stress +namespace: biological_process +def: "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress." [GOC:rb, PMID:23000173] +is_a: GO:0032984 ! protein-containing complex disassembly +relationship: part_of GO:0071276 ! cellular response to cadmium ion + +[Term] +id: GO:1990172 +name: G protein-coupled receptor catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor." [PMID:12142540, PMID:23954414] +synonym: "G-protein coupled receptor catabolic process" EXACT [] +is_a: GO:0032801 ! receptor catabolic process +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway + +[Term] +id: GO:1990173 +name: protein localization to nucleoplasm +namespace: biological_process +alt_id: GO:0032066 +def: "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] +synonym: "nucleolus to nucleoplasm transport" RELATED [] +synonym: "protein localisation to nucleoplasm" EXACT [GOC:mah] +is_a: GO:0034504 ! protein localization to nucleus + +[Term] +id: GO:1990174 +name: phosphodiesterase decapping endonuclease activity +namespace: molecular_function +def: "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481] +synonym: "G(5')pppN pyrophosphatase activity" RELATED [] +is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters + +[Term] +id: GO:1990175 +name: EH domain binding +namespace: molecular_function +def: "Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R." [GOC:hjd, PMID:11911876, PMID:21115825] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990176 +name: MalFGK2 complex +namespace: cellular_component +def: "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG." [GOC:bhm, PMID:19250913] +comment: The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060. +synonym: "MalF-MalG-MalK(2) complex" EXACT [GOC:bf] +synonym: "MalF-MalG-MalK-MalK complex" EXACT [GOC:bf] +synonym: "MalFGK(2) complex" EXACT [PMID:19250913] +synonym: "maltose transport complex, core subunit" EXACT [GOC:bhm] +synonym: "maltose transport MalFGK2 complex" EXACT [GOC:bhm] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:1990060 ! maltose transport complex + +[Term] +id: GO:1990177 +name: IHF-DNA complex +namespace: cellular_component +def: "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid." [GOC:bhm, PMID:17097674] +synonym: "IHF complex" EXACT [GOC:bhm] +synonym: "IHFa-IHFb-DNA complex" EXACT [GOC:bhm] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:1990104 ! DNA bending complex +relationship: part_of GO:0043590 ! bacterial nucleoid + +[Term] +id: GO:1990178 +name: HU-DNA complex +namespace: cellular_component +def: "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure." [GOC:bhm, PMID:17360520] +synonym: "HU complex" BROAD [GOC:bhm] +is_a: GO:0032993 ! protein-DNA complex +is_a: GO:1990104 ! DNA bending complex +relationship: part_of GO:0043590 ! bacterial nucleoid + +[Term] +id: GO:1990179 +name: protein localization to actomyosin contractile ring +namespace: biological_process +def: "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808] +synonym: "protein localisation to actomyosin contractile ring" EXACT [] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:0072741 ! protein localization to cell division site +is_a: GO:1903119 ! protein localization to actin cytoskeleton + +[Term] +id: GO:1990180 +name: mitochondrial tRNA 3'-end processing +namespace: biological_process +def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301] +synonym: "tRNA 3' processing in mitochondria" EXACT [GOC:TermGenie] +synonym: "tRNA 3' processing in mitochondrion" EXACT [GOC:TermGenie] +synonym: "tRNA 3'-end processing in mitochondria" EXACT [GOC:TermGenie] +is_a: GO:0000965 ! mitochondrial RNA 3'-end processing +is_a: GO:0042780 ! tRNA 3'-end processing +is_a: GO:0090646 ! mitochondrial tRNA processing + +[Term] +id: GO:1990181 +name: acetyl-CoA biosynthetic process from pantothenate +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA." [GOC:mah, PMID:23091701] +synonym: "acetyl-CoA anabolism from pantothenate" EXACT [] +synonym: "acetyl-CoA formation from pantothenate" RELATED [] +synonym: "acetyl-CoA synthesis from pantothenate" RELATED [] +is_a: GO:0006085 ! acetyl-CoA biosynthetic process +is_a: GO:0015939 ! pantothenate metabolic process + +[Term] +id: GO:1990182 +name: exosomal secretion +namespace: biological_process +def: "The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:10572093, PMID:12154376, PMID:16773132, PMID:18617898] +synonym: "exosomal protein secretion" NARROW [PMID:18617898] +synonym: "exosomal secretory pathway" EXACT [PMID:18617898] +synonym: "extracellular vesicular exosome secretion" EXACT [GOC:hjd] +synonym: "multi-vesicular body fusion with plasma membrane" EXACT [] +synonym: "secretion of exosome" EXACT [PMID:18617898] +is_a: GO:0006887 ! exocytosis +is_a: GO:0051650 ! establishment of vesicle localization +relationship: part_of GO:0097734 ! extracellular exosome biogenesis + +[Term] +id: GO:1990183 +name: lymphatic vascular process in circulatory system +namespace: biological_process +def: "A circulatory process that occurs at the level of the lymphatic vasculature." [PMID:21576390] +is_a: GO:0003018 ! vascular process in circulatory system + +[Term] +id: GO:1990184 +name: amino acid transport complex +namespace: cellular_component +def: "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:1990185 +name: regulation of lymphatic vascular permeability +namespace: biological_process +def: "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid." [PMID:23897233] +is_a: GO:0043114 ! regulation of vascular permeability +is_a: GO:1990183 ! lymphatic vascular process in circulatory system + +[Term] +id: GO:1990186 +name: regulation of lymphatic vessel size +namespace: biological_process +def: "Any process that modulates the size of lymphatic vessels." [PMID:23897233] +synonym: "regulation of collecting lymphatic vessel size" NARROW [] +is_a: GO:0090066 ! regulation of anatomical structure size +is_a: GO:1990183 ! lymphatic vascular process in circulatory system + +[Term] +id: GO:1990187 +name: obsolete protein localization to mRNA +namespace: biological_process +def: "OBSOLETE. A process in which a protein is transported to, or maintained at mRNA." [GOC:rb, PMID:22890846] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "protein localization to mRNA" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990188 +name: euchromatin binding +namespace: molecular_function +def: "Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512] +is_a: GO:0003682 ! chromatin binding + +[Term] +id: GO:1990189 +name: peptide-serine-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279] +is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity + +[Term] +id: GO:1990190 +name: peptide-glutamate-N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279] +is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity + +[Term] +id: GO:1990191 +name: cobalamin transport complex +namespace: cellular_component +def: "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD." [GOC:bhm, PMID:22569249] +synonym: "BtuCDF complex" EXACT [] +synonym: "cobalamin-transporting BtuCDF complex" EXACT [] +synonym: "vitamin B12 transport complex" EXACT [] +synonym: "vitamin B12-transporting BtuCDF complex" EXACT [] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:1990192 +name: collecting lymphatic vessel constriction +namespace: biological_process +def: "A decrease in the diameter of collecting lymphatic vessels." [PMID:23322290] +synonym: "lymphatic vessel myogenic constriction" EXACT [] +is_a: GO:1990186 ! regulation of lymphatic vessel size + +[Term] +id: GO:1990193 +name: BtuCD complex +namespace: cellular_component +def: "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer." [GOC:bhm, PMID:22569249] +synonym: "BtuC-BtuD complex" EXACT [] +synonym: "cobalamin transport complex, core subunit" EXACT [] +synonym: "vitamin B12 transport complex, core subunit" EXACT [] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:1990194 +name: cytoplasmic U snRNP body assembly +namespace: biological_process +def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282] +synonym: "U body assembly" RELATED [] +is_a: GO:0022618 ! ribonucleoprotein complex assembly + +[Term] +id: GO:1990195 +name: macrolide transmembrane transporter complex +namespace: cellular_component +def: "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725] +synonym: "AcrAB-TolC complex" NARROW [] +synonym: "MacAB-TolC complex" NARROW [] +synonym: "macrolide transporter" RELATED [] +synonym: "macrolide transporter complex" BROAD [] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1990196 +name: MacAB-TolC complex +namespace: cellular_component +def: "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725] +synonym: "macrolide transporter MacAB-TolC complex" EXACT [] +is_a: GO:1990195 ! macrolide transmembrane transporter complex + +[Term] +id: GO:1990197 +name: methionine-importing ABC transporter complex +namespace: cellular_component +def: "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner." [GOC:bhm, PMID:22095702] +synonym: "ATP-binding cassette (ABC) methionine importer complex" EXACT [] +synonym: "ATP-dependent methionine importer complex" EXACT [] +synonym: "ATP-dependent methionine importing complex" EXACT [] +synonym: "ATP-dependent methionine-importing complex" EXACT [] +synonym: "methionine transport complex" BROAD [] +synonym: "methionine transporter" RELATED [] +synonym: "methionine transporter complex" BROAD [] +synonym: "methionine transporter complex, ATP-dependent" BROAD [] +synonym: "MetNI complex" NARROW [] +synonym: "MetNI transport complex" NARROW [] +synonym: "MetNI transporter" RELATED [] +synonym: "MetNI transporter complex" NARROW [] +synonym: "MetNIQ complex" NARROW [] +synonym: "MetNIQ transport complex" NARROW [] +synonym: "MetNIQ transporter" RELATED [] +synonym: "MetNIQ transporter complex" RELATED [] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex +is_a: GO:1902509 ! methionine-importing complex + +[Term] +id: GO:1990198 +name: ModE complex +namespace: cellular_component +def: "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism." [GOC:bhm, PMID:12581638] +synonym: "ModE dimer" EXACT [GOC:bhm] +is_a: GO:0005667 ! transcription regulator complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990199 +name: MsbA transporter complex +namespace: cellular_component +def: "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD)." [GOC:bhm, PMID:18024585] +synonym: "MsbA complex" EXACT [GOC:bhm] +synonym: "MsbA dimer" EXACT [GOC:bhm] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:1990200 +name: SsuD-SsuE complex +namespace: cellular_component +def: "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation." [GOC:bhm, PMID:16997955] +synonym: "two-component alkanesulfonate monooxygenase system" RELATED [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990201 +name: alkanesulfonate monooxygenase complex +namespace: cellular_component +def: "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer." [GOC:bhm, PMID:10480865, PMID:16997955] +synonym: "SsuD complex" NARROW [GOC:bhm] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990202 +name: FMN reductase complex +namespace: cellular_component +def: "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer." [GOC:bhm, PMID:10480865, PMID:16997955] +synonym: "flavin oxidoreductase complex, NAD(P)H-dependent" BROAD [GOC:bhm] +synonym: "FMN oxidoreductase complex, NAD(P)H-dependent" RELATED [GOC:bhm] +synonym: "FMN reductase complex, NAD(P)H-dependent" EXACT [GOC:bhm] +synonym: "SsuE complex" NARROW [GOC:bhm] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990203 +name: MdtBC Complex +namespace: cellular_component +def: "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane." [GOC:bhm, PMID:20038594] +synonym: "multidrug efflux pump MdtBC" EXACT [GOC:bhm] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1990204 +name: oxidoreductase complex +namespace: cellular_component +def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] +subset: goslim_metagenomics +synonym: "oxidation-reduction complex" EXACT [] +synonym: "redox complex" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1990205 +name: taurine dioxygenase complex +namespace: cellular_component +def: "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD." [GOC:bhm, PMID:12741810] +synonym: "2-aminoethanesulfonate dioxygenase complex" EXACT [] +synonym: "alpha-ketoglutarate-dependent taurine dioxygenase complex" EXACT [] +synonym: "TauD complex" NARROW [] +is_a: GO:1990204 ! oxidoreductase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990206 +name: jasmonyl-Ile conjugate hydrolase activity +namespace: molecular_function +def: "Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine." [PMID:23943861] +synonym: "JA-Ile hydrolase" RELATED [] +is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds + +[Term] +id: GO:1990207 +name: EmrE multidrug transporter complex +namespace: cellular_component +def: "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer." [GOC:bhm, PMID:18024586] +synonym: "EmrE complex" NARROW [] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1902495 ! transmembrane transporter complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990208 +name: positive regulation by symbiont of RNA levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12182338, PMID:18703740] +is_a: GO:0052018 ! modulation by symbiont of RNA levels in host + +[Term] +id: GO:1990209 +name: negative regulation by symbiont of RNA levels in host +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18703740] +is_a: GO:0052018 ! modulation by symbiont of RNA levels in host + +[Term] +id: GO:1990210 +name: positive regulation by symbiont of indole acetic acid levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646] +synonym: "positive regulation by symbiont of auxin levels in host" EXACT [] +synonym: "positive regulation by symbiont of IAA levels in host" EXACT [] +is_a: GO:0044032 ! modulation by symbiont of indole acetic acid levels in host +is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host + +[Term] +id: GO:1990211 +name: positive regulation by symbiont of jasmonic acid levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:14617079, PMID:16553894] +is_a: GO:0052022 ! modulation by symbiont of jasmonic acid levels in host +is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host + +[Term] +id: GO:1990212 +name: positive regulation by symbiont of ethylene levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:16167902] +is_a: GO:0052021 ! modulation by symbiont of ethylene levels in host +is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host + +[Term] +id: GO:1990213 +name: negative regulation by symbiont of salicylic acid levels in host +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:17722699, PMID:20565685] +is_a: GO:0052023 ! modulation by symbiont of salicylic acid levels in host +is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host + +[Term] +id: GO:1990214 +name: obsolete negative regulation by symbiont of host protein levels +namespace: biological_process +def: "OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16840699, PMID:22233353] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:1990215 +name: negative regulation by symbiont of host intracellular transport +namespace: biological_process +def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451] +is_a: GO:0052038 ! modulation by symbiont of host intracellular transport +relationship: negatively_regulates GO:0046907 ! intracellular transport + +[Term] +id: GO:1990216 +name: positive regulation by symbiont of host transcription +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21994350] +is_a: GO:0052026 ! modulation by symbiont of host transcription + +[Term] +id: GO:1990217 +name: suppression by symbiont of host phytoalexin production +namespace: biological_process +def: "Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357] +synonym: "negative regulation by symbiont of host phytoalexin production" EXACT [] +is_a: GO:0052165 ! symbiont defense to host-produced phytoalexin + +[Term] +id: GO:1990218 +name: positive regulation by symbiont of abscisic acid levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17304219] +is_a: GO:0075343 ! modulation by symbiont of abscisic acid levels in host + +[Term] +id: GO:1990219 +name: obsolete positive regulation by symbiont of host protein levels +namespace: biological_process +def: "OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20615948] +comment: This term was obsoleted because it is a readout, and annotations should be made to more informative terms. +is_obsolete: true + +[Term] +id: GO:1990220 +name: GroEL-GroES complex +namespace: cellular_component +def: "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins." [GOC:bhm, PMID:15313620] +synonym: "bacterial chaperonin ATPase complex" RELATED [] +synonym: "bacterial chaperonin complex" RELATED [] +is_a: GO:0016465 ! chaperonin ATPase complex + +[Term] +id: GO:1990221 +name: L-cysteine desulfurase complex +namespace: cellular_component +def: "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer." [GOC:bhm, PMID:11827487] +synonym: "IscS" NARROW [GOC:bhm, GOC:dph] +synonym: "NifS" NARROW [GOC:bhm, GOC:dph] +synonym: "SufS complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990222 +name: ProVWX complex +namespace: cellular_component +def: "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions." [GOC:bhm, PMID:23249124] +synonym: "ATP-binding cassette (ABC) transporter complex ProVWX" EXACT [] +is_a: GO:0043190 ! ATP-binding cassette (ABC) transporter complex + +[Term] +id: GO:1990223 +name: positive regulation by symbiont of cytokinin levels in host +namespace: biological_process +def: "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24124900] +is_a: GO:0052024 ! positive regulation by symbiont of hormone or growth regulator levels in host + +[Term] +id: GO:1990224 +name: NMN phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate." [GOC:rb, PMID:21349851, RHEA:30815] +synonym: "beta-nicotinamide D-ribonucleotide phosphatase activity" EXACT [] +synonym: "nicotinamide mononucleotide phosphatase activity" EXACT [] +xref: RHEA:30815 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:1990225 +name: rhoptry neck +namespace: cellular_component +def: "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion." [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020008 ! rhoptry + +[Term] +id: GO:1990226 +name: histone methyltransferase binding +namespace: molecular_function +def: "Binding to a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:1990227 +name: paranodal junction maintenance +namespace: biological_process +def: "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [GOC:pr, PMID:24011083] +synonym: "axoglial septate junction maintenance" EXACT [] +synonym: "paranodal axoglial junction maintenance" EXACT [] +synonym: "paranodal septate maintenance" EXACT [] +is_a: GO:0045217 ! cell-cell junction maintenance + +[Term] +id: GO:1990228 +name: sulfurtransferase complex +namespace: cellular_component +def: "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:17350958] +synonym: "SufE complex" NARROW [GOC:bhm] +synonym: "SufE dimer" NARROW [GOC:bhm] +synonym: "sulfur transfer complex" EXACT [GOC:bhm] +synonym: "ThiF-ThiS complex" RELATED [GOC:bhm] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990229 +name: iron-sulfur cluster assembly complex +namespace: cellular_component +def: "A protein complex capable of assembling an iron-sulfur (Fe-S) cluster." [GOC:bhm, PMID:17350958] +synonym: "Fe-S cluster assembly complex" NARROW [GOC:bhm] +synonym: "SufBCD complex" NARROW [GOC:bhm] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990230 +name: iron-sulfur cluster transfer complex +namespace: cellular_component +def: "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:19810706] +synonym: "Fe-S cluster transfer complex" EXACT [GOC:bhm] +synonym: "IscA complex" NARROW [GOC:bhm] +synonym: "SufA complex" NARROW [GOC:bhm] +synonym: "SufA dimer" NARROW [GOC:bhm] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990231 +name: STING complex +namespace: cellular_component +def: "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378] +synonym: "stimulator of interferon genes complex" EXACT [GOC:bhm, PMID:22705373, PMID:23910378] +is_a: GO:0098796 ! membrane protein complex +relationship: part_of GO:0030659 ! cytoplasmic vesicle membrane + +[Term] +id: GO:1990232 +name: phosphomannomutase complex +namespace: cellular_component +def: "A protein complex capable of phosphomannomutase activity." [GOC:bhm, PMID:16540464] +synonym: "PMM-1 complex" NARROW [GOC:bhm] +synonym: "PMM-1 dimer" NARROW [GOC:bhm] +synonym: "PMM-2 complex" NARROW [GOC:bhm] +synonym: "PMM-2 dimer" NARROW [GOC:bhm] +is_a: GO:1990233 ! intramolecular phosphotransferase complex + +[Term] +id: GO:1990233 +name: intramolecular phosphotransferase complex +namespace: cellular_component +def: "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule." [GOC:bhm, PMID:16540464] +is_a: GO:1902494 ! catalytic complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990234 +name: transferase complex +namespace: cellular_component +def: "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1990235 +name: diamine N-acetyltransferase complex +namespace: cellular_component +def: "A protein complex which is capable of diamine N-acetyltransferase activity." [GOC:bhm, PMID:8077207] +synonym: "SAT complex" NARROW [GOC:bhm] +synonym: "SAT tetramer" NARROW [GOC:bhm] +synonym: "spermidine acetyltransferase complex" NARROW [GOC:bhm] +is_a: GO:1902493 ! acetyltransferase complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990236 +name: proteasome core complex import into nucleus +namespace: biological_process +def: "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus." [GOC:dos, GOC:rb, PMID:23982732] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051170 ! import into nucleus + +[Term] +id: GO:1990238 +name: double-stranded DNA endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:PG, PMID:22885404] +synonym: "dsDNA-specific endodeoxyribonuclease activity" RELATED [] +is_a: GO:0004520 ! endodeoxyribonuclease activity + +[Term] +id: GO:1990239 +name: steroid hormone binding +namespace: molecular_function +def: "Binding to a steroid hormone." [GOC:ln] +is_a: GO:0005496 ! steroid binding +is_a: GO:0042562 ! hormone binding + +[Term] +id: GO:1990241 +name: obsolete nucleotide binding complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6)." [GOC:bhm, PMID:23910378] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "nucleotide binding complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990242 +name: obsolete innate immune response complex +namespace: cellular_component +def: "OBSOLETE. A protein complex involved in the innate immune response." [GOC:bhm, PMID:23910378] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "innate immune response complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990243 +name: atf1-pcr1 complex +namespace: cellular_component +def: "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE)." [PMID:24224056] +is_a: GO:0035976 ! transcription factor AP-1 complex + +[Term] +id: GO:1990244 +name: histone kinase activity (H2A-T120 specific) +namespace: molecular_function +def: "Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A." [PMID:24140421] +synonym: "histone threonine kinase activity (H2A-T120 specific)" EXACT [] +is_a: GO:0035184 ! histone threonine kinase activity + +[Term] +id: GO:1990245 +name: histone H2A-T120 phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone." [PMID:24140421] +synonym: "histone H2A phosphorylation at T120" EXACT [] +synonym: "histone H2AT120 phosphorylation" EXACT [] +is_a: GO:0035405 ! histone-threonine phosphorylation +is_a: GO:1990164 ! histone H2A phosphorylation + +[Term] +id: GO:1990246 +name: uniplex complex +namespace: cellular_component +def: "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807] +synonym: "mitochondrial uniporter complex" EXACT [] +synonym: "mitochondrial uniporter holocomplex" EXACT [] +is_a: GO:0034704 ! calcium channel complex +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:1990247 +name: N6-methyladenosine-containing RNA binding +namespace: molecular_function +def: "Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:1990248 +name: regulation of transcription from RNA polymerase II promoter in response to DNA damage +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129] +is_a: GO:0006974 ! cellular response to DNA damage stimulus +is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:1990249 +name: nucleotide-excision repair, DNA damage recognition complex +namespace: cellular_component +def: "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990250 +name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex +namespace: cellular_component +def: "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906] +is_a: GO:1990249 ! nucleotide-excision repair, DNA damage recognition complex + +[Term] +id: GO:1990251 +name: nuclear exosome focus +namespace: cellular_component +def: "An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome." [GOC:al, GOC:vw, PMID:16823445, PMID:23980030, PMID:32012158] +synonym: "Mmi1 nuclear focus" EXACT [] +synonym: "nuclear body" RELATED [] +is_a: GO:0016604 ! nuclear body + +[Term] +id: GO:1990252 +name: Syp1 complex +namespace: cellular_component +def: "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis." [GOC:bhm, PMID:19713939] +synonym: "Syp1 dimer" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle + +[Term] +id: GO:1990253 +name: cellular response to leucine starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384] +is_a: GO:0034198 ! cellular response to amino acid starvation + +[Term] +id: GO:1990254 +name: keratin filament binding +namespace: molecular_function +def: "Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061] +is_a: GO:0019215 ! intermediate filament binding + +[Term] +id: GO:1990255 +name: subsynaptic reticulum organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:21041451] +is_a: GO:0006996 ! organelle organization + +[Term] +id: GO:1990256 +name: signal clustering +namespace: biological_process +def: "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response." [GOC:als, PMID:12011072, PMID:15603739] +synonym: "ligand clustering" BROAD [GOC:als] +is_a: GO:0009966 ! regulation of signal transduction + +[Term] +id: GO:1990257 +name: piccolo-bassoon transport vesicle +namespace: cellular_component +def: "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270] +synonym: "PTV" RELATED [] +is_a: GO:0030133 ! transport vesicle + +[Term] +id: GO:1990258 +name: histone glutamine methylation +namespace: biological_process +def: "The modification of a histone by addition of a methyl group to an glutamine residue." [PMID:24352239] +is_a: GO:0016571 ! histone methylation +is_a: GO:0018364 ! peptidyl-glutamine methylation + +[Term] +id: GO:1990259 +name: histone-glutamine methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine." [PMID:24352239] +is_a: GO:0036009 ! protein-glutamine N-methyltransferase activity +is_a: GO:0042054 ! histone methyltransferase activity + +[Term] +id: GO:1990260 +name: negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling." [PMID:24006488] +is_a: GO:0010621 ! negative regulation of transcription by transcription factor localization +relationship: part_of GO:0072423 ! response to DNA damage checkpoint signaling + +[Term] +id: GO:1990261 +name: pre-mRNA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259] +synonym: "pre-mRNA decay" EXACT [] +synonym: "unspliced RNA decay" EXACT [] +is_a: GO:0006401 ! RNA catabolic process + +[Term] +id: GO:1990262 +name: anti-Mullerian hormone signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:hjd, PMID:23624077] +comment: An example of this is Amhr2 in M. musculus (Q8K592) a receptor for anti-mullerian hormone, described in PMID:23624077. +is_a: GO:0007166 ! cell surface receptor signaling pathway + +[Term] +id: GO:1990263 +name: spore wall assembly MAPK cascade +namespace: biological_process +def: "A MAPK cascade that occurs as a result of deprivation of nourishment." [GOC:al, PMID:7501024] +synonym: "MAPK cascade in response to starvation" EXACT [] +synonym: "MAPK cascade involved in nutrient response signaling" EXACT [GOC:al] +is_a: GO:0009267 ! cellular response to starvation +is_a: GO:0051403 ! stress-activated MAPK cascade + +[Term] +id: GO:1990264 +name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity +namespace: biological_process +def: "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024] +is_a: GO:0035335 ! peptidyl-tyrosine dephosphorylation +relationship: part_of GO:0006469 ! negative regulation of protein kinase activity + +[Term] +id: GO:1990265 +name: platelet-derived growth factor complex +namespace: cellular_component +def: "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD)." [GOC:bhm, PMID:11331882] +comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay). +synonym: "PDGF complex" RELATED [] +synonym: "PDGF-AA dimer" NARROW [] +synonym: "PDGF-AB dimer" NARROW [] +synonym: "PDGF-BB dimer" NARROW [] +synonym: "PDGF-CC dimer" NARROW [] +synonym: "PDGF-DD dimer" NARROW [] +is_a: GO:0036454 ! growth factor complex + +[Term] +id: GO:1990266 +name: neutrophil migration +namespace: biological_process +def: "The movement of a neutrophil within or between different tissues and organs of the body." [PMID:1826836] +is_a: GO:0097530 ! granulocyte migration + +[Term] +id: GO:1990267 +name: response to transition metal nanoparticle +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627] +synonym: "response to colloidal metal" RELATED [] +synonym: "response to neutral metal atoms" RELATED [] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1990268 +name: response to gold nanoparticle +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus." [PMID:23150627] +is_a: GO:1990267 ! response to transition metal nanoparticle + +[Term] +id: GO:1990269 +name: RNA polymerase II C-terminal domain phosphoserine binding +namespace: molecular_function +def: "Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944] +synonym: "RNA Pol II C-terminal domain phosphoserine binding" EXACT [GOC:di] +synonym: "RNAP II C-terminal domain phosphoserine binding" EXACT [] +is_a: GO:0050815 ! phosphoserine residue binding +is_a: GO:0099122 ! RNA polymerase II C-terminal domain binding + +[Term] +id: GO:1990270 +name: platelet-derived growth factor receptor-ligand complex +namespace: cellular_component +def: "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, PMID:11331882] +comment: An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay). +synonym: "PDGF complex" BROAD [] +synonym: "PDGF receptor-ligand complex" EXACT [] +synonym: "PDGF-AA-receptor alpha complex" NARROW [] +synonym: "PDGF-AB-receptor alpha complex" NARROW [] +synonym: "PDGF-AB-receptor beta complex" NARROW [] +synonym: "PDGF-BB-receptor alpha complex" NARROW [] +synonym: "PDGF-BB-receptor alpha-beta complex" NARROW [] +synonym: "PDGF-BB-receptor beta complex" NARROW [] +synonym: "PDGF-CC-receptor alpha complex" NARROW [] +synonym: "PDGF-CC-receptor alpha-beta complex" NARROW [] +synonym: "PDGF-CC-receptor beta complex" NARROW [] +synonym: "PDGF-DD-receptor alpha-beta complex" NARROW [] +synonym: "PDGF-DD-receptor beta complex" NARROW [] +synonym: "receptor-ligand complex" BROAD [] +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990271 +name: obsolete anti-Mullerian hormone +namespace: molecular_function +def: "OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077] +comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077. +synonym: "anti-Mullerian hormone" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990272 +name: anti-Mullerian hormone receptor activity +namespace: molecular_function +def: "Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077] +comment: An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077. +is_a: GO:0016500 ! protein-hormone receptor activity + +[Term] +id: GO:1990273 +name: snRNA 5'-end processing +namespace: biological_process +def: "Any process involved in forming the mature 5' end of an snRNA molecule." [PMID:22740346] +is_a: GO:0016180 ! snRNA processing +is_a: GO:0034471 ! ncRNA 5'-end processing + +[Term] +id: GO:1990274 +name: mitotic actomyosin contractile ring disassembly +namespace: biological_process +def: "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673] +synonym: "mitotic actomyosin ring disassembly" RELATED [] +synonym: "mitotic CAR disassembly" EXACT [] +synonym: "mitotic constriction ring disassembly" RELATED [] +synonym: "mitotic contractile actomyosin ring disassembly" EXACT [] +synonym: "mitotic cytokinetic ring disassembly" RELATED [] +is_a: GO:1902410 ! mitotic cytokinetic process +is_a: GO:1902621 ! actomyosin contractile ring disassembly + +[Term] +id: GO:1990275 +name: preribosome binding +namespace: molecular_function +def: "Binding to a preribosome." [GOC:di, PMID:22735702] +is_a: GO:0043021 ! ribonucleoprotein complex binding + +[Term] +id: GO:1990276 +name: RNA 5'-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule." [GOC:al, GOC:vw, PMID:22740346] +is_a: GO:0008171 ! O-methyltransferase activity +is_a: GO:0008173 ! RNA methyltransferase activity +is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity + +[Term] +id: GO:1990277 +name: parasexual conjugation with cellular fusion +namespace: biological_process +def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types, without the formation of zygotes. An example of this process is found in Candida albicans." [GOC:di] +synonym: "mating" BROAD [] +is_a: GO:0000746 ! conjugation +is_a: GO:0140253 ! cell-cell fusion + +[Term] +id: GO:1990278 +name: obsolete positive regulation of MBF transcription factor activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF." [PMID:11795845] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "positive regulation of MBF transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990279 +name: obsolete negative regulation of MBF transcription factor activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF." [PMID:24006488] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "negative regulation of MBF transcription factor activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990280 +name: RNA localization to chromatin +namespace: biological_process +def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] +synonym: "RNA localisation to chromatin" EXACT [] +is_a: GO:0006403 ! RNA localization + +[Term] +id: GO:1990281 +name: efflux pump complex +namespace: cellular_component +def: "A protein complex that is capable of efflux transmembrane transporter activity." [GOC:dos, PMID:21556065, PMID:9417051] +synonym: "efflux pump" EXACT [] +synonym: "efflux transmembrane transporter complex" EXACT [] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1990294 +name: peptidyl-threonine trans-autophosphorylation +namespace: biological_process +def: "The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [PMID:19357077] +is_a: GO:0018107 ! peptidyl-threonine phosphorylation +is_a: GO:0036290 ! protein trans-autophosphorylation + +[Term] +id: GO:1990295 +name: post-anaphase microtubule array +namespace: cellular_component +def: "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091] +comment: The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical. +synonym: "PAA" EXACT [] +synonym: "post-anaphase array" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015630 ! microtubule cytoskeleton + +[Term] +id: GO:1990297 +name: renal amino acid absorption +namespace: biological_process +def: "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:hjd, PMID:1526373] +is_a: GO:0070293 ! renal absorption + +[Term] +id: GO:1990298 +name: bub1-bub3 complex +namespace: cellular_component +def: "Protein complex that associates with the kinetochores." [PMID:22521786] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990299 +name: Bub1-Bub3 complex localization to kinetochore +namespace: biological_process +def: "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore." [PMID:22521786] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0034501 ! protein localization to kinetochore + +[Term] +id: GO:1990300 +name: cellulosome binding +namespace: molecular_function +alt_id: GO:1990301 +def: "Binding to a cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides." [GOC:mengo_curators, PMID:11893054, PMID:15197390] +synonym: "scaffoldin complex binding" NARROW [] +is_a: GO:0005488 ! binding + +[Term] +id: GO:1990302 +name: Bre1-Rad6 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, PMID:19531475] +comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). +synonym: "Bre1-Rad6 complex" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005622 ! intracellular anatomical structure + +[Term] +id: GO:1990303 +name: UBR1-RAD6 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." [GOC:bhm, PMID:19531475] +comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). +synonym: "UBR1-RAD6 complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1990304 +name: MUB1-RAD6-UBR2 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme." [GOC:bhm, PMID:18070918] +comment: This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918. +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1990305 +name: RAD6-UBR2 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation." [GOC:bhm, PMID:15504724] +comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:15504724 +synonym: "RAD6-UBR2 complex" EXACT [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1990306 +name: RSP5-BUL ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, PMID:9931424] +comment: This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424 +synonym: "RSP5-BUL1 complex" EXACT [] +synonym: "RSP5-BUL2 complex" RELATED [] +is_a: GO:0140535 ! intracellular protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1990308 +name: type-I dockerin domain binding +namespace: molecular_function +def: "Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990309 +name: type-II dockerin domain binding +namespace: molecular_function +def: "Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990310 +name: type-III dockerin domain binding +namespace: molecular_function +def: "Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990311 +name: type-I cohesin domain binding +namespace: molecular_function +def: "Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990312 +name: type-II cohesin domain binding +namespace: molecular_function +def: "Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990313 +name: type-III cohesin domain binding +namespace: molecular_function +def: "Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain." [GOC:mengo_curators, PMID:23195689, PMID:24080387] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990314 +name: cellular response to insulin-like growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:20042609] +synonym: "cellular response to insulin-like growth factor" EXACT [] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus + +[Term] +id: GO:1990315 +name: Mcs4 RR-MAPKKK complex +namespace: cellular_component +def: "A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress." [PMID:24255738] +comment: In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1. +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990316 +name: Atg1/ULK1 kinase complex +namespace: cellular_component +alt_id: GO:0034273 +alt_id: GO:0070969 +def: "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598] +synonym: "ATG1 kinase complex" EXACT [] +synonym: "ATG1-ATG13 complex" EXACT [] +synonym: "ATG1/ULK1 signaling complex" EXACT [] +synonym: "Atg1p signalling complex" EXACT [] +synonym: "autophagy-initiation complex" EXACT [GOC:autophagy, GOC:pad, GOC:PARL, PMID:26754330] +synonym: "ULK complex" EXACT [PMID:28816597] +synonym: "ULK1 complex" EXACT [PMID:26921696] +synonym: "ULK1 signaling complex" EXACT [] +synonym: "ULK1-ATG13-FIP200 complex" EXACT [] +synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [] +is_a: GO:1902554 ! serine/threonine protein kinase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990317 +name: Gin4 complex +namespace: cellular_component +def: "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved." [GOC:bhm, PMID:12058072] +synonym: "Gin4-septin complex" EXACT [] +is_a: GO:1902554 ! serine/threonine protein kinase complex +relationship: part_of GO:0000144 ! cellular bud neck septin ring + +[Term] +id: GO:1990318 +name: collagen type XIX trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells." [GOC:bhm, PMID:17876790] +is_a: GO:0005593 ! FACIT collagen trimer +is_a: GO:0098651 ! basement membrane collagen trimer + +[Term] +id: GO:1990319 +name: collagen type XX trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XX) chains." [GOC:bhm, PMID:17876790] +is_a: GO:0005593 ! FACIT collagen trimer + +[Term] +id: GO:1990320 +name: collagen type XXI trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle." [GOC:bhm, PMID:17876790] +is_a: GO:0005593 ! FACIT collagen trimer + +[Term] +id: GO:1990321 +name: collagen type XXII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts." [GOC:bhm, PMID:17876790] +is_a: GO:0005593 ! FACIT collagen trimer + +[Term] +id: GO:1990322 +name: collagen type XXIII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790] +is_a: GO:0030936 ! transmembrane collagen trimer + +[Term] +id: GO:1990323 +name: collagen type XXIV trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development." [GOC:bhm, PMID:17876790] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:1990324 +name: collagen type XXVI trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXVI) chains." [GOC:bhm, PMID:17876790] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:1990325 +name: collagen type XXVII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." [GOC:bhm, PMID:17876790, PMID:21421911] +is_a: GO:0005583 ! fibrillar collagen trimer + +[Term] +id: GO:1990326 +name: collagen type XXVIII trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXVIII) chains." [GOC:bhm, PMID:17876790] +is_a: GO:0005581 ! collagen trimer +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:1990327 +name: collagen type XXV trimer +namespace: cellular_component +def: "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane." [GOC:bhm, PMID:17876790] +is_a: GO:0030936 ! transmembrane collagen trimer + +[Term] +id: GO:1990328 +name: RPB4-RPB7 complex +namespace: cellular_component +def: "A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways." [GOC:bhm, PMID:15591044] +synonym: "RNA polymerase II, RPB4-RPB7 subcomplex" NARROW [] +is_a: GO:0140535 ! intracellular protein-containing complex + +[Term] +id: GO:1990329 +name: IscS-TusA complex +namespace: cellular_component +def: "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups." [GOC:bhm, PMID:20404999] +is_a: GO:1990221 ! L-cysteine desulfurase complex +is_a: GO:1990228 ! sulfurtransferase complex + +[Term] +id: GO:1990330 +name: IscS-IscU complex +namespace: cellular_component +def: "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group." [GOC:bhm, PMID:20404999] +is_a: GO:1990221 ! L-cysteine desulfurase complex +is_a: GO:1990228 ! sulfurtransferase complex + +[Term] +id: GO:1990331 +name: Hpa2 acetyltransferase complex +namespace: cellular_component +def: "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules." [GOC:bhm, PMID:10600387] +is_a: GO:0070775 ! H3 histone acetyltransferase complex +is_a: GO:1902562 ! H4 histone acetyltransferase complex + +[Term] +id: GO:1990332 +name: Ire1 complex +namespace: cellular_component +def: "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript." [GOC:bf, GOC:bhm, PMID:18191223, PMID:25437541] +comment: An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay). +synonym: "ERN1 complex" RELATED [HGNC:3449] +synonym: "IRE1 dimer" EXACT [PMID:25437541] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1902554 ! serine/threonine protein kinase complex +is_a: GO:1902555 ! endoribonuclease complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:1990333 +name: mitotic checkpoint complex, CDC20-MAD2 subcomplex +namespace: cellular_component +def: "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20." [GOC:bhm, PMID:15879521] +comment: An example of this is cdc20 in Saccharomyces cerevisiae (P26309) in PMID:15879521 (inferred from direct assay). +synonym: "CDC20-MAD2 complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0033597 ! mitotic checkpoint complex + +[Term] +id: GO:1990334 +name: Bfa1-Bub2 complex +namespace: cellular_component +def: "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, PMID:16449187] +is_a: GO:1902773 ! GTPase activator complex +relationship: part_of GO:0005816 ! spindle pole body + +[Term] +id: GO:1990338 +name: laminin-14 complex +namespace: cellular_component +def: "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709] +synonym: "laminin-423" EXACT [GOC:dph, GOC:sl, PMID:15979864] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:1990339 +name: laminin-522 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains." [GOC:bhm, GOC:dph, PMID:15979864, PMID:17453709] +synonym: "laminin-522" EXACT [] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:1990340 +name: laminin-15 complex +namespace: cellular_component +def: "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains." [GOC:bhm, PMID:17453709] +synonym: "laminin-523" EXACT [] +is_a: GO:0043256 ! laminin complex + +[Term] +id: GO:1990341 +name: thrombospondin complex +namespace: cellular_component +def: "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour." [GOC:bhm, PMID:18193164] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0031012 ! extracellular matrix + +[Term] +id: GO:1990342 +name: heterochromatin island +namespace: cellular_component +def: "A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi." [PMID:22144463, PMID:24210919] +comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth. +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:1990343 +name: heterochromatin domain +namespace: cellular_component +def: "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919] +comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons. +synonym: "HOOD" EXACT [PMID:23151475] +is_a: GO:0000792 ! heterochromatin + +[Term] +id: GO:1990344 +name: secondary cell septum biogenesis +namespace: biological_process +def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259] +is_a: GO:0044085 ! cellular component biogenesis +is_a: GO:1902410 ! mitotic cytokinetic process +relationship: part_of GO:0140278 ! mitotic division septum assembly + +[Term] +id: GO:1990346 +name: BID-BCL-xl complex +namespace: cellular_component +def: "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, PMID:14634621] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990347 +name: obsolete G*/A mismatch-specific adenine-DNA glycosylase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site." [PMID:24559510] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "G*/A mismatch-specific adenine-DNA glycosylase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990348 +name: obsolete G/A mismatch specific adenine DNA glycosylase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me." [PMID:9737967] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "G/A mismatch specific adenine DNA glycosylase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990349 +name: gap junction-mediated intercellular transport +namespace: biological_process +def: "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells." [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction] +is_a: GO:0010496 ! intercellular transport + +[Term] +id: GO:1990350 +name: glucose transporter complex +namespace: cellular_component +def: "A protein complex facilitating glucose transport into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] +comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:1990351 +name: transporter complex +namespace: cellular_component +def: "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, PMID:15449578] +comment: An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990352 +name: BRE1 E3 ubiquitin ligase complex +namespace: cellular_component +def: "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes." [GOC:bhm, PMID:19531475] +comment: An example of this is BRE1 in Saccharomyces cerevisiae (UniProt symbol Q07457) in PMID:19531475 (inferred from direct assay). +synonym: "BRE1 E3 ubiquitin-protein ligase complex" EXACT [] +synonym: "BRE1 oligomer" EXACT [] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:1990353 +name: Fused-Smurf ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation." [GOC:bhm, PMID:21145463] +comment: An example of this is FUSED in Drosophila melanogaster (UniProt symbol P23647) in PMID:21145463 (inferred from direct assay). +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:1990354 +name: activated SUMO-E1 ligase complex +namespace: cellular_component +def: "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins." [GOC:bhm, PMID:15660128] +comment: An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay). +synonym: "SUMO-SAE1/2 complex" NARROW [] +is_a: GO:0106068 ! SUMO ligase complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:1990355 +name: L-methionine salvage from methionine sulphoxide +namespace: biological_process +def: "The generation of L-methionine from methionine sulphoxide." [PMID:24118096] +synonym: "methionine salvage from methionine sulphoxide" BROAD [] +is_a: GO:0071267 ! L-methionine salvage + +[Term] +id: GO:1990356 +name: sumoylated E2 ligase complex +namespace: cellular_component +def: "A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase." [GOC:bhm, PMID:18691969] +comment: An example of this is UBC9 in human (UniProt symbol P63279) in PMID:18691969 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990357 +name: terminal web +namespace: cellular_component +def: "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells." [GOC:kmv, PMID:19437512, PMID:24677443, PMID:7511618, Wikipedia:Terminal_web] +is_a: GO:0030864 ! cortical actin cytoskeleton + +[Term] +id: GO:1990358 +name: xylanosome +namespace: cellular_component +def: "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose." [GOC:mengo_curators, PMID:16769147] +synonym: "xylanolytic complex" EXACT [] +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1990359 +name: stress response to zinc ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus." [GOC:kmv, pmid:17888400] +synonym: "response to zinc ion stress" EXACT [] +synonym: "response to zinc toxicity" RELATED [] +synonym: "stress response to zinc" BROAD [] +is_a: GO:0010043 ! response to zinc ion +is_a: GO:0097501 ! stress response to metal ion + +[Term] +id: GO:1990360 +name: PKM2 protein kinase complex +namespace: cellular_component +def: "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer." [GOC:bhm, PMID:24606918] +synonym: "PKM2-SAICAR complex" RELATED [] +synonym: "PKM2-SAICAR protein kinase complex" RELATED [] +is_a: GO:1902911 ! protein kinase complex + +[Term] +id: GO:1990361 +name: PKM2 pyruvate kinase complex +namespace: cellular_component +def: "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013)." [GOC:bhm, PMID:24606918] +comment: An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). +synonym: "PKM2 homotetramer" EXACT [] +is_a: GO:1902912 ! pyruvate kinase complex + +[Term] +id: GO:1990362 +name: butanol dehydrogenase activity +namespace: molecular_function +def: "Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+." [GOC:mengo_curators, PMID:1999395, RHEA:33199] +xref: RHEA:33199 +is_a: GO:0004022 ! alcohol dehydrogenase (NAD+) activity + +[Term] +id: GO:1990363 +name: obsolete response to hydrolysate +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis)." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to hydrolysate" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990364 +name: obsolete response to aldehyde +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to aldehyde" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990365 +name: obsolete response to phenol +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to phenol" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990366 +name: obsolete response to organic acid +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to organic acid" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990368 +name: obsolete process resulting in tolerance to hydrolysate +namespace: biological_process +def: "OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis)." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "process resulting in tolerance to hydrolysate" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990370 +name: obsolete process resulting in tolerance to aldehyde +namespace: biological_process +def: "OBSOLETE. A response that results in a state of tolerance to aldehyde." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted because it does not represent a clear process. +is_obsolete: true + +[Term] +id: GO:1990371 +name: obsolete process resulting in tolerance to phenol +namespace: biological_process +def: "OBSOLETE. A response that results in a state of tolerance to phenol." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted because it does not represent a clear process. +is_obsolete: true + +[Term] +id: GO:1990372 +name: obsolete process resulting in tolerance to organic acid +namespace: biological_process +def: "OBSOLETE. A response that results in a state of tolerance to organic acid." [GOC:mengo_curators, PMID:23356676] +comment: This term was obsoleted because it does not represent a clear process. +is_obsolete: true + +[Term] +id: GO:1990374 +name: Kir2 inward rectifier potassium channel complex +namespace: cellular_component +def: "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells." [GOC:bhm, PMID:16834334] +comment: An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). +synonym: "Kir2.1 complex" NARROW [] +is_a: GO:1902937 ! inward rectifier potassium channel complex + +[Term] +id: GO:1990375 +name: baculum development +namespace: biological_process +def: "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296] +synonym: "os penis development" EXACT [GOC:sl] +synonym: "penile bone development" EXACT [GOC:sl] +synonym: "penis bone development" EXACT [GOC:sl] +is_a: GO:0048608 ! reproductive structure development +is_a: GO:0060348 ! bone development + +[Term] +id: GO:1990376 +name: obsolete negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition." [PMID:9135083] +comment: This term was made obsolete because it would not be used for annotation. +is_obsolete: true + +[Term] +id: GO:1990377 +name: organomineral extracellular matrix +namespace: cellular_component +def: "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight." [GOC:jh2, PMID:15994301] +comment: An example is found in shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis (PMID:15994301), but the term may also be useful to annotate bone and eggshell proteins. +is_a: GO:0031012 ! extracellular matrix + +[Term] +id: GO:1990378 +name: upstream stimulatory factor complex +namespace: cellular_component +def: "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters." [GOC:bhm, PMID:8576131] +comment: An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay). +synonym: "USF complex" EXACT [] +synonym: "USF1 homodimer" NARROW [] +synonym: "USF1-USF2 heterodimer" NARROW [] +synonym: "USF2 homodimer" NARROW [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990379 +name: lipid transport across blood-brain barrier +namespace: biological_process +def: "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162] +synonym: "lipid transport across blood brain barrier" EXACT [] +is_a: GO:0006869 ! lipid transport +is_a: GO:0150104 ! transport across blood-brain barrier + +[Term] +id: GO:1990380 +name: Lys48-specific deubiquitinase activity +namespace: molecular_function +def: "Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:bf, GOC:PARL, PMID:22970133] +synonym: "K48-specific deubiquitinase activity" EXACT [PMID:22970133] +synonym: "K48-specific deubiquitinating activity" EXACT [PMID:22970133] +xref: Reactome:R-HSA-5690870 "OTUD7B,TNFAIP3 deubiquitinate TRAF6" +is_a: GO:0101005 ! deubiquitinase activity + +[Term] +id: GO:1990381 +name: ubiquitin-specific protease binding +namespace: molecular_function +def: "Binding to a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750] +synonym: "deubiquitinase binding" EXACT [GOC:bf] +synonym: "deubiquitinating enzyme binding" EXACT [PMID:24063750] +is_a: GO:0002020 ! protease binding + +[Term] +id: GO:1990382 +name: obsolete melanosome assembly +namespace: biological_process +def: "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:bf, GOC:PARL, PMID:22511774] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "melanosome biogenesis" EXACT [PMID:22511774] +is_obsolete: true + +[Term] +id: GO:1990383 +name: cellular response to biotin starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin." [PMID:12557275] +is_a: GO:0009267 ! cellular response to starvation + +[Term] +id: GO:1990384 +name: hyaloid vascular plexus regression +namespace: biological_process +def: "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression." [GOC:hjd, PMID:18841878] +is_a: GO:0060033 ! anatomical structure regression +relationship: part_of GO:0043010 ! camera-type eye development + +[Term] +id: GO:1990385 +name: meiotic spindle midzone +namespace: cellular_component +def: "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv, PMID:12707312] +is_a: GO:0051233 ! spindle midzone +relationship: part_of GO:0072687 ! meiotic spindle + +[Term] +id: GO:1990386 +name: mitotic cleavage furrow ingression +namespace: biological_process +def: "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [GOC:kmv, PMID:12707312] +is_a: GO:0036090 ! cleavage furrow ingression +is_a: GO:1902410 ! mitotic cytokinetic process + +[Term] +id: GO:1990387 +name: isogloboside biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides)." [GOC:hjd, PMID:22875802] +is_a: GO:0006688 ! glycosphingolipid biosynthetic process +is_a: GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:1990388 +name: xylem-to-phloem iron transport +namespace: biological_process +def: "The directed movement of iron ions into the phloem from the xylem." [GOC:tb, PMID:24867923] +is_a: GO:0006826 ! iron ion transport +is_a: GO:0010233 ! phloem transport + +[Term] +id: GO:1990389 +name: CUE1-UBC7 ubiquitin-conjugating enzyme complex +namespace: cellular_component +def: "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1." [GOC:bhm, PMID:23028185] +comment: An example of this is UBC7 in Saccharomyces cerevisiae (Q02159) in PMID:16179953 (inferred from direct assay). +synonym: "CUE1-UBC7 ubiquitin-conjugating enzyme (E2)" EXACT [] +is_a: GO:0000835 ! ER ubiquitin ligase complex +is_a: GO:0031371 ! ubiquitin conjugating enzyme complex + +[Term] +id: GO:1990390 +name: protein K33-linked ubiquitination +namespace: biological_process +def: "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein." [PMID:24768539] +is_a: GO:0000209 ! protein polyubiquitination + +[Term] +id: GO:1990391 +name: DNA repair complex +namespace: cellular_component +def: "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350] +synonym: "DNA damage repair complex" EXACT [] +synonym: "WHY1 complex" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990392 +name: EFF-1 complex +namespace: cellular_component +def: "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer." [GOC:bhm, PMID:24725407] +comment: An example of this is eff-1 in C. elegans (G5ECA1) in PMID:24725407 (inferred from direct assay). +is_a: GO:0098797 ! plasma membrane protein complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990393 +name: 3M complex +namespace: cellular_component +def: "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity." [PMID:24793695, PMID:24793696] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990394 +name: cellular response to cell wall damage +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell." [PMID:17287531] +is_a: GO:0051716 ! cellular response to stimulus + +[Term] +id: GO:1990395 +name: meiotic spindle pole body organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw] +is_a: GO:0051300 ! spindle pole body organization +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0000212 ! meiotic spindle organization + +[Term] +id: GO:1990396 +name: single-strand break repair via homologous recombination +namespace: biological_process +def: "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:bhm, PMID:24339919] +is_a: GO:0000012 ! single strand break repair +is_a: GO:0000725 ! recombinational repair +is_a: GO:0042275 ! error-free postreplication DNA repair + +[Term] +id: GO:1990397 +name: queuosine salvage +namespace: biological_process +def: "Any process which produces queuosine from derivatives of it, without de novo synthesis." [GOC:vw, PMID:24911101] +is_a: GO:0008616 ! queuosine biosynthetic process +is_a: GO:0043174 ! nucleoside salvage + +[Term] +id: GO:1990398 +name: Cus cation efflux complex +namespace: cellular_component +def: "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth." [GOC:bhm, PMID:23122209] +comment: An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209. +synonym: "copper efflux complex" NARROW [] +synonym: "copper efflux system" NARROW [] +synonym: "Cus cation efflux system" EXACT [] +synonym: "silver efflux complex" NARROW [] +synonym: "silver efflux system" NARROW [] +is_a: GO:0098797 ! plasma membrane protein complex +is_a: GO:1903113 ! copper ion transmembrane transporter complex +is_a: GO:1903114 ! silver ion transmembrane transporter complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990399 +name: epithelium regeneration +namespace: biological_process +def: "The regrowth of lost or destroyed epithelium." [GOC:sl, PMID:19845688] +synonym: "regeneration of epithelium" EXACT [] +is_a: GO:0042246 ! tissue regeneration +is_a: GO:0060429 ! epithelium development + +[Term] +id: GO:1990400 +name: mitochondrial ribosomal large subunit rRNA binding +namespace: molecular_function +def: "Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA)." [PMID:24206665] +comment: In S. cerevisiae, this is the mitochondrial 21S rRNA +synonym: "21S rRNA binding" NARROW [] +synonym: "mitochondrial LSU rRNA binding" EXACT [] +is_a: GO:0070180 ! large ribosomal subunit rRNA binding + +[Term] +id: GO:1990401 +name: embryonic lung development +namespace: biological_process +def: "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure." [PMID:24785085] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:1990402 +name: embryonic liver development +namespace: biological_process +def: "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure." [PMID:15918910] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:1990403 +name: embryonic brain development +namespace: biological_process +def: "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910] +is_a: GO:0048568 ! embryonic organ development + +[Term] +id: GO:1990404 +name: protein ADP-ribosylase activity +namespace: molecular_function +def: "The transfer, from NAD, of ADP-ribose to a protein amino acid residue." [PMID:1899243, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295, wikipedia:ADP-ribosylation] +synonym: "ribosylase activity" BROAD [] +is_a: GO:0016763 ! pentosyltransferase activity +is_a: GO:0140096 ! catalytic activity, acting on a protein + +[Term] +id: GO:1990405 +name: protein antigen binding +namespace: molecular_function +def: "Binding to a protein antigen." [PMID:9360996] +is_a: GO:0003823 ! antigen binding +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:1990406 +name: CGRP receptor complex +namespace: cellular_component +def: "A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP)." [GOC:bhm, PMID:20826335] +comment: An example of this is CALCRL in human (Q16602) in PMID:20826335 (inferred from direct assay). +synonym: "calcitonin gene-related polypeptide receptor complex" EXACT [] +synonym: "Calcitonin-gene-related peptide receptor complex" EXACT [] +synonym: "CGRP-R complex" EXACT [] +is_a: GO:1903439 ! calcitonin family receptor complex + +[Term] +id: GO:1990407 +name: calcitonin gene-related peptide binding +namespace: molecular_function +def: "Binding to calcitonin gene-related peptide (CGRP)." [GOC:bhm, PMID:10882736] +comment: An example of this is CALCRL in human (Q16602) in PMID:10882736 (inferred from direct assay/mutant phenotype/etc.). +synonym: "calcitonin-gene-related peptide binding" EXACT [] +synonym: "calcitonin-gene-related polypeptide binding" EXACT [] +synonym: "CGRP polypeptide binding" EXACT [] +is_a: GO:0097644 ! calcitonin family binding + +[Term] +id: GO:1990408 +name: calcitonin gene-related peptide receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers." [GOC:bhm, PMID:10882736] +comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. +synonym: "calcitonin-gene-related peptide receptor signaling pathway" EXACT [] +synonym: "calcitonin-gene-related polypeptide receptor signaling pathway" EXACT [] +synonym: "CGRP receptor signaling pathway" EXACT [] +is_a: GO:0097646 ! calcitonin family receptor signaling pathway + +[Term] +id: GO:1990409 +name: adrenomedullin binding +namespace: molecular_function +def: "Binding to adrenomedullin (AM)." [GOC:bhm, PMID:10882736] +comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. +synonym: "AM binding" EXACT [] +is_a: GO:0097644 ! calcitonin family binding + +[Term] +id: GO:1990410 +name: adrenomedullin receptor signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell." [GOC:bhm, PMID:10882736] +comment: An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. +synonym: "AM receptor signaling pathway" EXACT [] +is_a: GO:0097646 ! calcitonin family receptor signaling pathway + +[Term] +id: GO:1990411 +name: hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) +namespace: molecular_function +def: "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium." [PMID:24828577] +xref: MetaCyc:RXN-14428 +xref: RHEA:42688 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:1990412 +name: hercynylselenocysteine lyase activity (selenoneine-forming) +namespace: molecular_function +def: "Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium." [PMID:24828577] +xref: RHEA:42696 +is_a: GO:0016846 ! carbon-sulfur lyase activity + +[Term] +id: GO:1990413 +name: eyespot apparatus +namespace: cellular_component +def: "A small pigmented organelle used in single-celled organisms to detect light." [Wikipedia:Eyespot_apparatus] +synonym: "eyespot" RELATED [] +synonym: "stigma" RELATED [] +is_a: GO:0043231 ! intracellular membrane-bounded organelle + +[Term] +id: GO:1990414 +name: replication-born double-strand break repair via sister chromatid exchange +namespace: biological_process +def: "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [GOC:rb, PMID:12820977, PMID:16888651] +synonym: "replication-born DSB repair by SCE" EXACT [] +is_a: GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:1990416 +name: cellular response to brain-derived neurotrophic factor stimulus +namespace: biological_process +def: "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus." [PMID:21958434] +synonym: "cellular response to BDNF stimulus" EXACT [] +is_a: GO:1990090 ! cellular response to nerve growth factor stimulus + +[Term] +id: GO:1990417 +name: snoRNA release from pre-rRNA +namespace: biological_process +def: "The release of snoRNA from pre-rRNA." [GOC:rb, PMID:16908538] +comment: An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay. +is_a: GO:0006364 ! rRNA processing + +[Term] +id: GO:1990418 +name: response to insulin-like growth factor stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:21932665] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:1990419 +name: obsolete response to elemental metal +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus." [PMID:22688007] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to elemental metal" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990420 +name: establishment of septation initiation network asymmetry +namespace: biological_process +def: "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies." [PMID:22786806] +synonym: "establishment of SIN asymmetry" EXACT [PMID:22786806] +is_a: GO:0031028 ! septation initiation signaling + +[Term] +id: GO:1990422 +name: glyoxalase (glycolic acid-forming) activity +namespace: molecular_function +def: "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor." [GOC:bf, GOC:PARL, PMID:22523093] +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:1990423 +name: RZZ complex +namespace: cellular_component +def: "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495] +comment: Example annotations for this term would be D. melanogaster mit(1)15 (Q9W4X9), rod and zwilch (Q9VA00). +synonym: "Rod-Zwilch-Zw10 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0000776 ! kinetochore + +[Term] +id: GO:1990424 +name: protein arginine kinase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate." [GOC:imk, PMID:22517742] +comment: This reaction occurs in bacterial species e.g. Bacillus subtilis. +is_a: GO:0004672 ! protein kinase activity + +[Term] +id: GO:1990425 +name: ryanodine receptor complex +namespace: cellular_component +def: "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom." [GOC:ame, PMID:22822064] +comment: An example of this is RyR1 in rabbit (P11716) in PMID:2550460 (inferred from electron microscopy). +synonym: "RyR" RELATED [] +is_a: GO:0005891 ! voltage-gated calcium channel complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:1990426 +name: mitotic recombination-dependent replication fork processing +namespace: biological_process +def: "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942] +synonym: "homologous recombination dependent replication fork recovery" RELATED [PMID:23093942] +synonym: "homologous recombination-dependent replication fork processing" EXACT [] +is_a: GO:0031297 ! replication fork processing +is_a: GO:1990505 ! mitotic DNA replication maintenance of fidelity + +[Term] +id: GO:1990427 +name: stereocilia tip-link density +namespace: cellular_component +def: "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane." [PMID:19447093, PMID:21709241] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0002140 ! stereocilia tip link +relationship: part_of GO:0042995 ! cell projection + +[Term] +id: GO:1990428 +name: miRNA transport +namespace: biological_process +def: "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GO:jl, PMID:24356509] +synonym: "microRNA transport" EXACT [] +is_a: GO:0050658 ! RNA transport + +[Term] +id: GO:1990429 +name: peroxisomal importomer complex +namespace: cellular_component +alt_id: GO:1990415 +def: "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:12667447, PMID:20154681, PMID:22375831] +synonym: "peroxisomal import pore" EXACT [] +synonym: "peroxisomal protein import machinery" EXACT [] +synonym: "Pex14 complex" NARROW [] +synonym: "Pex17p-Pex14p docking complex" RELATED [] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:1990430 +name: extracellular matrix protein binding +namespace: molecular_function +def: "Binding to a protein that is part of an extracellular matrix." [PMID:22355679] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:1990431 +name: priRNA 3'-end processing +namespace: biological_process +def: "The process of forming the mature 3' end of a priRNA molecule." [PMID:24095277] +synonym: "primal small RNA 3'-end processing" EXACT [] +synonym: "priRNA 3' end processing" EXACT [] +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:1990432 +name: siRNA 3'-end processing +namespace: biological_process +def: "The process of forming the mature 3' end of a siRNA molecule." [PMID:24095277] +synonym: "siRNA 3' end processing" EXACT [] +synonym: "small interfering RNA 3'-end processing" EXACT [] +is_a: GO:0043628 ! ncRNA 3'-end processing + +[Term] +id: GO:1990433 +name: CSL-Notch-Mastermind transcription factor complex +namespace: cellular_component +def: "A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes." [GOC:bhm, GOC:dos, PMID:16530045] +synonym: "CSL-NotchIC-MASTERMIND complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990434 +name: lower tip-link density +namespace: cellular_component +def: "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises." [PMID:19447093] +synonym: "LTLD" EXACT [] +is_a: GO:1990427 ! stereocilia tip-link density + +[Term] +id: GO:1990435 +name: upper tip-link density +namespace: cellular_component +def: "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends." [PMID:19447093] +synonym: "UTLD" EXACT [] +is_a: GO:1990427 ! stereocilia tip-link density + +[Term] +id: GO:1990436 +name: obsolete MAPK cascade involved in oxidative stress signaling pathway +namespace: biological_process +def: "OBSOLETE. A series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term." [PMID:10398679] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "MAPK cascade involved in oxidative stress signaling pathway" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990437 +name: snRNA 2'-O-methylation +namespace: biological_process +def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635] +is_a: GO:0106349 ! snRNA methylation + +[Term] +id: GO:1990438 +name: U6 2'-O-snRNA methylation +namespace: biological_process +def: "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635] +is_a: GO:1990437 ! snRNA 2'-O-methylation + +[Term] +id: GO:1990439 +name: MAP kinase serine/threonine phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate." [PMID:10398679] +is_a: GO:0004722 ! protein serine/threonine phosphatase activity +is_a: GO:0033549 ! MAP kinase phosphatase activity + +[Term] +id: GO:1990440 +name: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145] +synonym: "activation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] +synonym: "ER stress-induced upregulation of transcription" BROAD [GOC:bf] +synonym: "stimulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] +synonym: "up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "up-regulation of transcription induced by ER stress" BROAD [GOC:bf, PMID:21113145] +synonym: "upregulation of Pol II transcription induced by ER stress" EXACT [GOC:bf, PMID:21113145] +synonym: "upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] +is_a: GO:0034976 ! response to endoplasmic reticulum stress +is_a: GO:0036003 ! positive regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:1990441 +name: negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145] +synonym: "down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "ER stress-induced negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:bf] +synonym: "inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress" EXACT [GOC:bf] +synonym: "negative regulation of transcription from RNA polymerase II promoter in response to ER stress" EXACT [GOC:bf] +synonym: "reduction of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] +synonym: "repression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] +synonym: "suppression of transcription from RNA polymerase II promoter under ER stress" EXACT [PMID:21113145] +is_a: GO:0034976 ! response to endoplasmic reticulum stress +is_a: GO:0097201 ! negative regulation of transcription from RNA polymerase II promoter in response to stress + +[Term] +id: GO:1990442 +name: intrinsic apoptotic signaling pathway in response to nitrosative stress +namespace: biological_process +def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:bf, GOC:PARL, PMID:23985028] +synonym: "nitrosative stress-induced apoptosis" RELATED [PMID:23985028] +synonym: "nitrosative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] +is_a: GO:0071500 ! cellular response to nitrosative stress +is_a: GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:1990443 +name: peptidyl-threonine autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein." [PMID:7803855] +is_a: GO:0018107 ! peptidyl-threonine phosphorylation +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:1990444 +name: F-box domain binding +namespace: molecular_function +def: "Binding to an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990445 +name: obsolete Multiciliate cell differentiation +namespace: biological_process +def: "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems." [PMID:22231168, PMID:24934224] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "Multiciliate cell differentiation" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990446 +name: U1 snRNP binding +namespace: molecular_function +def: "Binding to a U1 small nuclear ribonucleoprotein particle." [PMID:14713954] +is_a: GO:0070990 ! snRNP binding + +[Term] +id: GO:1990447 +name: U2 snRNP binding +namespace: molecular_function +def: "Binding to a U2 small nuclear ribonucleoprotein particle." [PMID:14713954] +is_a: GO:0070990 ! snRNP binding + +[Term] +id: GO:1990448 +name: exon-exon junction complex binding +namespace: molecular_function +def: "Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [GOC:sart, PMID:24967911] +synonym: "EJC binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1990449 +name: obsolete amylin receptor +namespace: cellular_component +def: "OBSOLETE. A G protein-coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss." [GOC:bhm, PMID:10871269] +comment: An example of this is CALCR in human (P30988) in PMID:10871269. +synonym: "AMY1 receptor" NARROW [] +synonym: "AMY2 receptor" NARROW [] +synonym: "AMY3 receptor" NARROW [] +synonym: "amylin receptor" EXACT [] +synonym: "CALCR-RAMP1 receptor" NARROW [] +synonym: "CALCR-RAMP2 receptor" NARROW [] +synonym: "CALCR-RAMP3 receptor" NARROW [] +is_obsolete: true + +[Term] +id: GO:1990450 +name: linear polyubiquitin binding +namespace: molecular_function +def: "Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807] +synonym: "M1-linked ubiquitin chain binding" EXACT [PMID:23453807] +is_a: GO:0043130 ! ubiquitin binding + +[Term] +id: GO:1990451 +name: cellular stress response to acidic pH +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution." [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049] +comment: An example of this is NOX1 in human (Q9Y5S8) in PMID:10615049. +synonym: "cellular stress response to acidity" BROAD [] +is_a: GO:0062197 ! cellular response to chemical stress +is_a: GO:0071468 ! cellular response to acidic pH + +[Term] +id: GO:1990452 +name: Parkin-FBXW7-Cul1 ubiquitin ligase complex +namespace: cellular_component +def: "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165] +synonym: "Park2-FBXW7-Cul1 complex" EXACT [GOC:bf] +synonym: "Parkin-FBXW7-Cul1 protein complex" EXACT [GOC:bf] +synonym: "Parkin-HSel-10-Cullin-1 complex" NARROW [PMID:12628165] +synonym: "Parkin/Cul1/F-box protein complex" EXACT [GOC:bf] +synonym: "PRKN-FBXW7-Cul1 complex" EXACT [] +is_a: GO:0000151 ! ubiquitin ligase complex + +[Term] +id: GO:1990453 +name: nucleosome disassembly/reassembly complex +namespace: cellular_component +def: "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex." [GOC:bhm, PMID:24843044] +comment: An example of this is EAF7 in Saccharomyces cerevisiae (P53911) in PMID:24843044 (inferred from direct assay). +synonym: "eaf5/7/3 complex" NARROW [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:1990454 +name: L-type voltage-gated calcium channel complex +namespace: cellular_component +def: "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation." [GOC:ame, PMID:12946355] +comment: Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay). +synonym: "cardiac muscle L-type voltage-gated calcium channel complex" NARROW [] +synonym: "skeletal muscle L-type voltage-gated calcium channel complex" NARROW [] +is_a: GO:0005891 ! voltage-gated calcium channel complex +relationship: part_of GO:0030315 ! T-tubule + +[Term] +id: GO:1990455 +name: PTEN phosphatase complex +namespace: cellular_component +def: "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function." [GOC:bhm, PMID:24766807] +comment: An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). +synonym: "phosphatase and tensin homolog" EXACT [] +synonym: "phosphatase and tensin homolog deleted on chromosome ten homodimer" EXACT [] +synonym: "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer" EXACT [] +is_a: GO:1904144 ! phosphatidylinositol phosphate phosphatase complex + +[Term] +id: GO:1990456 +name: mitochondrion-endoplasmic reticulum membrane tethering +namespace: biological_process +def: "The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:19556461, PMID:27875684] +synonym: "mitochondrion-endoplasmic reticulum attachment" EXACT [] +synonym: "mitochondrion-endoplasmic reticulum tethering" EXACT [] +synonym: "mitochondrion-ER attachment" EXACT [] +synonym: "mitochondrion-ER membrane tethering" EXACT [] +synonym: "mitochondrion-ER tethering" EXACT [] +is_a: GO:0016043 ! cellular component organization +is_a: GO:0140056 ! organelle localization by membrane tethering + +[Term] +id: GO:1990457 +name: pexophagosome +namespace: cellular_component +def: "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy." [PMID:22536249] +is_a: GO:0045335 ! phagocytic vesicle + +[Term] +id: GO:1990458 +name: lipooligosaccharide binding +namespace: molecular_function +def: "Binding to lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria." [GOC:hjd, PMID:8894399] +comment: ChEBI distinguishes an oligosaccharide from a polysaccharide as the latter being anything of length 10 or greater. +synonym: "endotoxin binding" RELATED [] +synonym: "LOS binding" RELATED [] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:1990459 +name: transferrin receptor binding +namespace: molecular_function +def: "Binding to a transferrin receptor." [GOC:pm, PMID:9819414] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:1990460 +name: leptin receptor binding +namespace: molecular_function +def: "Binding to a leptin receptor." [GOC:pm, PMID:22405007] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:1990461 +name: detoxification of iron ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556] +is_a: GO:0061687 ! detoxification of inorganic compound +relationship: part_of GO:0010039 ! response to iron ion + +[Term] +id: GO:1990462 +name: omegasome +namespace: cellular_component +def: "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649] +is_a: GO:0043231 ! intracellular membrane-bounded organelle +relationship: part_of GO:0012505 ! endomembrane system + +[Term] +id: GO:1990463 +name: lateral cortical node +namespace: cellular_component +def: "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287] +synonym: "Skb1-containing cortical node" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0097575 ! lateral cell cortex + +[Term] +id: GO:1990464 +name: D-2-hydroxyacid dehydrogenase (quinone) activity +namespace: molecular_function +def: "Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol." [EC:1.1.5.10, GOC:am, PMID:3013300, PMID:4582730] +comment: (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. +synonym: "(R)-2-hydroxy acid dehydrogenase activity" RELATED [EC:1.1.5.10] +synonym: "(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity" RELATED [EC:1.1.5.10] +synonym: "(R)-2-hydroxyacid:quinone oxidoreductase activity" RELATED [EC:1.1.5.10] +synonym: "D-lactate dehydrogenase (quinone) activity" RELATED [GOC:am] +synonym: "D-lactate dehydrogenase activity" RELATED [EC:1.1.5.10] +synonym: "D-lactate:quinone oxidoreductase activity" RELATED [GOC:am] +is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor + +[Term] +id: GO:1990465 +name: aldehyde oxygenase (deformylating) activity +namespace: molecular_function +def: "Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+)." [GOC:mengo_curators, PMID:22947199, RHEA:21440] +xref: EC:4.1.99.5 +xref: RHEA:21440 +is_a: GO:0016830 ! carbon-carbon lyase activity + +[Term] +id: GO:1990466 +name: protein autosumoylation +namespace: biological_process +def: "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663] +synonym: "protein auto-sumoylation" EXACT [] +synonym: "protein self-sumoylation" EXACT [] +is_a: GO:0016925 ! protein sumoylation + +[Term] +id: GO:1990467 +name: NuA3a histone acetyltransferase complex +namespace: cellular_component +def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p." [GOC:rb, PMID:25104842] +is_a: GO:0033100 ! NuA3 histone acetyltransferase complex + +[Term] +id: GO:1990468 +name: NuA3b histone acetyltransferase complex +namespace: cellular_component +def: "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p." [GOC:rb, PMID:25104842] +is_a: GO:0033100 ! NuA3 histone acetyltransferase complex + +[Term] +id: GO:1990469 +name: Rhino-Deadlock-Cutoff Complex +namespace: cellular_component +def: "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation." [GOC:bhm, PMID:24906153] +comment: An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153. +synonym: "RDC complex" EXACT [] +synonym: "rhi-del-cuff complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0043073 ! germ cell nucleus + +[Term] +id: GO:1990470 +name: piRNA cluster binding +namespace: molecular_function +def: "Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)." [GOC:bhm, PMID:24906153] +comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). +is_a: GO:1990837 ! sequence-specific double-stranded DNA binding + +[Term] +id: GO:1990471 +name: piRNA uni-strand cluster binding +namespace: molecular_function +def: "Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa." [GOC:bhm, PMID:24906153] +is_a: GO:1990470 ! piRNA cluster binding + +[Term] +id: GO:1990472 +name: piRNA dual-strand cluster binding +namespace: molecular_function +def: "Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription." [GOC:bhm, PMID:24906153] +comment: An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). +is_a: GO:1990470 ! piRNA cluster binding + +[Term] +id: GO:1990473 +name: ciliary targeting signal binding +namespace: molecular_function +def: "Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane." [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559] +synonym: "CTS binding" EXACT [] +is_a: GO:0005048 ! signal sequence binding + +[Term] +id: GO:1990474 +name: synaptic vesicle, readily releasable pool +namespace: cellular_component +def: "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton." [GOC:pad, PMID:22745285] +synonym: "readily releasable pool of synaptic vesicles" EXACT [] +synonym: "RRP" RELATED [] +is_a: GO:0008021 ! synaptic vesicle +relationship: part_of GO:0043195 ! terminal bouton + +[Term] +id: GO:1990475 +name: synaptic vesicle, recycling pool +namespace: cellular_component +def: "A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state." [GOC:pad, PMID:22745285] +synonym: "recycling pool of synaptic vesicles" EXACT [] +is_a: GO:0008021 ! synaptic vesicle +relationship: part_of GO:0098794 ! postsynapse + +[Term] +id: GO:1990476 +name: synaptic vesicle, resting pool +namespace: cellular_component +def: "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool." [GOC:pad, PMID:22745285] +synonym: "reserve pool of synaptic vesicles" EXACT [PMID:15611727] +synonym: "resting pool of synaptic vesicles" EXACT [] +is_a: GO:0008021 ! synaptic vesicle +relationship: part_of GO:0043195 ! terminal bouton + +[Term] +id: GO:1990477 +name: MTREC complex +namespace: cellular_component +alt_id: GO:1990345 +def: "Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex." [PMID:24210919, PMID:24713849, PMID:32012158] +comment: An example of this is the complex formed by Red1 and Mtl1 in S. pombe (UniProt symbols Q9UTR8 and O13799 respectively) in PMID:24210919 (inferred from direct assay). +synonym: "Mtl1-Red1 core complex" EXACT [PMID:24210919] +synonym: "NURS complex" EXACT [] +synonym: "PAXT complex" EXACT [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:1990478 +name: response to ultrasound +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus." [PMID:20950932] +is_a: GO:0009612 ! response to mechanical stimulus + +[Term] +id: GO:1990479 +name: obsolete response to lipoic acid +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [PMID:23232760] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to 5-(1,2-dithiolan-3-yl)pentanoic acid" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990480 +name: obsolete geranyl diphosphate synthase +namespace: molecular_function +def: "OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis." [GOC:mengo_curators, PMID:10557273] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true +replaced_by: GO:0004161 + +[Term] +id: GO:1990481 +name: mRNA pseudouridine synthesis +namespace: biological_process +def: "The intramolecular conversion of uridine to pseudouridine in an mRNA molecule." [PMID:25192136] +synonym: "mRNA pseudouridylation" EXACT [] +is_a: GO:0001522 ! pseudouridine synthesis +is_a: GO:0016556 ! mRNA modification + +[Term] +id: GO:1990482 +name: sphingolipid alpha-glucuronosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC." [GOC:tb, PMID:25122154] +synonym: "inositol phosphorylceramide glucuronosyltransferase activity" RELATED [] +is_a: GO:0008194 ! UDP-glycosyltransferase activity + +[Term] +id: GO:1990483 +name: Clr6 histone deacetylase complex I'' +namespace: cellular_component +def: "A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3." [PMID:25002536] +is_a: GO:0000118 ! histone deacetylase complex +relationship: part_of GO:0000785 ! chromatin + +[Term] +id: GO:1990484 +name: aerobic lactate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen." [GOC:mengo_curators, PMID:8941775] +synonym: "aerobic lactic acid catabolic process" RELATED [] +is_a: GO:1903457 ! lactate catabolic process + +[Term] +id: GO:1990485 +name: anaerobic lactate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen." [GOC:mengo_curators, PMID:11133436] +synonym: "anaerobic lactic acid catabolic process" RELATED [] +is_a: GO:1903457 ! lactate catabolic process + +[Term] +id: GO:1990486 +name: anaerobic fatty acid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mengo_curators, PMID:17329794] +synonym: "anaerobic fatty acid degradation" EXACT [] +is_a: GO:0009062 ! fatty acid catabolic process + +[Term] +id: GO:1990487 +name: anaerobic lignin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units." [DOI:10.1039/C3EE40932E, GOC:mengo_curators] +synonym: "anaerobic lignin degradation" EXACT [] +is_a: GO:0046274 ! lignin catabolic process + +[Term] +id: GO:1990488 +name: anaerobic cellulose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen." [GOC:mengo_curators, PMID:8561466] +synonym: "anaerobic cellulose degradation" EXACT [] +is_a: GO:0030245 ! cellulose catabolic process + +[Term] +id: GO:1990489 +name: anaerobic pectin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." [GOC:mengo_curators, PMID:23079077] +synonym: "anaerobic pectin degradation" EXACT [] +is_a: GO:0045490 ! pectin catabolic process + +[Term] +id: GO:1990490 +name: archaeal proton-transporting A-type ATPase complex +namespace: cellular_component +def: "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." [GOC:mengo_curators, PMID:15473999, PMID:24650628] +synonym: "A-type ATPase protein complex" BROAD [] +synonym: "archaeal A-type ATPase protein complex" BROAD [] +is_a: GO:0016469 ! proton-transporting two-sector ATPase complex + +[Term] +id: GO:1990491 +name: methane biosynthetic process from methanol and hydrogen +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen." [GOC:mengo_curators, PMID:16347126] +synonym: "methane biosynthesis from methanol and hydrogen" EXACT [] +synonym: "methanogenesis from methanol and hydrogen" EXACT [] +is_a: GO:0015945 ! methanol metabolic process +is_a: GO:0019387 ! methanogenesis, from methanol +is_a: GO:1902421 ! hydrogen metabolic process + +[Term] +id: GO:1990492 +name: obsolete mitotic cell cycle checkpoint inhibiting CAR assembly +namespace: biological_process +def: "OBSOLETE. A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase." [PMID:12186944] +comment: This term was obsoleted because it does not represent a specific process. +synonym: "Mad2-dependent mitotic cell cycle checkpoint" RELATED [GOC:dph, GOC:vw] +synonym: "mitotic cell cycle checkpoint inhibiting cytokinetic actomyosin ring assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990493 +name: obsolete cyclin H-CDK7 complex +namespace: cellular_component +def: "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:9857180] +comment: This term was made obsolete because it was added in error. +synonym: "cyclin H-CDK7 complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990494 +name: obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly." [PMID:18256290] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of mitotic cytokinesis, actomyosin contractile ring assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990495 +name: obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly +namespace: biological_process +def: "OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:8834798] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990496 +name: obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly +namespace: biological_process +def: "OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:24798735] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990497 +name: regulation of cytoplasmic translation in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445] +is_a: GO:0043555 ! regulation of translation in response to stress +is_a: GO:2000765 ! regulation of cytoplasmic translation + +[Term] +id: GO:1990498 +name: mitotic spindle microtubule +namespace: cellular_component +def: "Any microtubule that is part of a mitotic spindle; anchored at one spindle pole." [GOC:vw] +is_a: GO:0005876 ! spindle microtubule +relationship: part_of GO:0072686 ! mitotic spindle + +[Term] +id: GO:1990499 +name: raps-insc complex +namespace: cellular_component +def: "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2)." [GOC:bhm, PMID:22171003] +comment: An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction). +synonym: "partner of inscuteable-inscuteable complex" EXACT [] +synonym: "Rapsynoid-Inscuteable complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0045179 ! apical cortex + +[Term] +id: GO:1990500 +name: eif4e-cup complex +namespace: cellular_component +def: "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo." [GOC:bhm, PMID:14723848] +comment: An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). +synonym: "eukaryotic translation initiation factor 4E-cup complex" EXACT [] +is_a: GO:1903502 ! translation repressor complex +relationship: part_of GO:0000932 ! P-body + +[Term] +id: GO:1990501 +name: exon-exon junction subcomplex mago-y14 +namespace: cellular_component +def: "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, PMID:12730685] +comment: An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay). +synonym: "exon junction subcomplex MAGOH-Y14" EXACT [GOC:bhm] +synonym: "mago-y14 complex" RELATED [] +synonym: "MGN-RBM8A complex" EXACT [] +is_a: GO:0035145 ! exon-exon junction complex +is_a: GO:1903503 ! ATPase inhibitor complex + +[Term] +id: GO:1990502 +name: dense core granule maturation +namespace: biological_process +def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] +synonym: "dense core vesicle maturation" EXACT [] +is_a: GO:0061792 ! secretory granule maturation + +[Term] +id: GO:1990503 +name: dendritic lamellar body +namespace: cellular_component +def: "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions." [PMID:7869120] +synonym: "DLB" EXACT [] +is_a: GO:0042599 ! lamellar body +relationship: part_of GO:0030425 ! dendrite + +[Term] +id: GO:1990504 +name: dense core granule exocytosis +namespace: biological_process +def: "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208] +synonym: "dense core vesicle exocytosis" EXACT [] +is_a: GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:1990505 +name: mitotic DNA replication maintenance of fidelity +namespace: biological_process +alt_id: GO:1990510 +def: "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." [PMID:19185548] +synonym: "maintenance of fidelity involved in mitotic cell cycle DNA replication" EXACT [] +synonym: "maintenance of fidelity involved in mitotic DNA replication" EXACT [] +is_a: GO:1902298 ! cell cycle DNA replication maintenance of fidelity +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1990506 +name: mitotic DNA-dependent DNA replication +namespace: biological_process +def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle." [PMID:16120966] +is_a: GO:1902969 ! mitotic DNA replication + +[Term] +id: GO:1990507 +name: obsolete ATP-independent chaperone mediated protein folding +namespace: biological_process +def: "OBSOLETE. The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis." [GOC:rb, PMID:25242142] +comment: This term was obsoleted because it represents a molecular function. +is_obsolete: true +consider: GO:0006457 +consider: GO:0044183 + +[Term] +id: GO:1990508 +name: CKM complex +namespace: cellular_component +def: "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." [GOC:bhm, PMID:12200444] +comment: An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction). +synonym: "CDK8 kinase module" EXACT [] +synonym: "SRB8-SRB11 complex" EXACT [] +synonym: "SRB8/9/10/11 complex" EXACT [] +is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:1990509 +name: PYM-mago-Y14 complex +namespace: cellular_component +def: "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans." [GOC:bhm, PMID:14968132] +comment: An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction). +synonym: "PYM-mago-RNA-binding protein 8A complex" EXACT [] +synonym: "wibg-mago-tsu complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990511 +name: piRNA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [GOC:kmv, PMID:24696457] +synonym: "Piwi-associated RNA biosynthetic process" EXACT [] +is_a: GO:0034587 ! piRNA metabolic process + +[Term] +id: GO:1990512 +name: Cry-Per complex +namespace: cellular_component +def: "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms." [GOC:bhm, PMID:24855952] +comment: An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction). +is_a: GO:0017053 ! transcription repressor complex +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:1990513 +name: CLOCK-BMAL transcription complex +namespace: cellular_component +def: "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, PMID:23229515] +comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction). +synonym: "CLOCK/BMAL complex" EXACT [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990514 +name: 5' transitive RNA interference +namespace: biological_process +def: "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430] +is_a: GO:0036453 ! transitive RNA interference + +[Term] +id: GO:1990515 +name: 3' transitive RNA interference +namespace: biological_process +def: "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430] +is_a: GO:0036453 ! transitive RNA interference + +[Term] +id: GO:1990516 +name: ribonucleotide excision repair +namespace: biological_process +def: "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase." [PMID:12475934, PMID:22864116] +is_a: GO:0070716 ! mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication + +[Term] +id: GO:1990517 +name: obsolete protein localization to photoreceptor outer segment +namespace: biological_process +def: "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium." [GOC:krc, PMID:20212494] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990518 +name: single-stranded 3'-5' DNA helicase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823] +is_a: GO:0017116 ! single-stranded DNA helicase activity +is_a: GO:0043138 ! 3'-5' DNA helicase activity + +[Term] +id: GO:1990519 +name: pyrimidine nucleotide import into mitochondrion +namespace: biological_process +def: "The process in which a pyrimidine nucleotide is transported across the mitochondrial inner membrane, into the mitochondrial matrix." [PMID:16194150] +synonym: "mitochondrial pyrimidine nucleotide import" EXACT [] +is_a: GO:0006864 ! pyrimidine nucleotide transport +is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990520 +name: separase-securin complex +namespace: cellular_component +def: "A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC)." [GOC:dos, GOC:vw, PMID:8978688] +synonym: "Cut1-2 complex" EXACT [PMID:8978688] +is_a: GO:1905369 ! endopeptidase complex + +[Term] +id: GO:1990521 +name: m7G(5')pppN diphosphatase activator activity +namespace: molecular_function +def: "Binds to and increases the activity of m7G(5')pppN diphosphatase." [PMID:22323607] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:1990522 +name: tail spike morphogenesis +namespace: biological_process +def: "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death." [GOC:kmv, PMID:17329362, PMID:6684600] +xref: WBbt:0006979 +xref: WBbt:0008072 +is_a: GO:0009653 ! anatomical structure morphogenesis + +[Term] +id: GO:1990523 +name: bone regeneration +namespace: biological_process +def: "The regrowth of bone following its loss or destruction." [PMID:25257467] +is_a: GO:0042246 ! tissue regeneration + +[Term] +id: GO:1990524 +name: INA complex +namespace: cellular_component +def: "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p." [GOC:rn, PMID:24942160] +synonym: "INAC" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex +relationship: part_of GO:0031304 ! intrinsic component of mitochondrial inner membrane + +[Term] +id: GO:1990525 +name: BIR domain binding +namespace: molecular_function +def: "Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain." [GOC:ha, InterPro:IPR001370] +comment: An example of this is the Drosophila reaper gene in PMID:21886178. +synonym: "Baculovirus Inhibitor of apoptosis protein Repeat domain binding" EXACT [] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990526 +name: Ste12p-Dig1p-Dig2p complex +namespace: cellular_component +def: "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990527 +name: Tec1p-Ste12p-Dig1p complex +namespace: cellular_component +def: "A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae." [GOC:rb, PMID:16782869] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990528 +name: Rvs161p-Rvs167p complex +namespace: cellular_component +def: "A protein complex that is involved in endocytosis in the yeast S. cerevisiae." [GOC:rb, PMID:20610658] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990529 +name: glycosylphosphatidylinositol-mannosyltransferase I complex +namespace: cellular_component +def: "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094] +synonym: "GPI-MT-I complex" RELATED [] +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +is_a: GO:1990234 ! transferase complex + +[Term] +id: GO:1990530 +name: Cdc50p-Drs2p complex +namespace: cellular_component +def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome." [GOC:rb, PMID:15090616, PMID:22234261] +is_a: GO:1990531 ! phospholipid-translocating ATPase complex + +[Term] +id: GO:1990531 +name: phospholipid-translocating ATPase complex +namespace: cellular_component +def: "A protein complex that functions as a phospholipid-translocating P-Type ATPase." [GOC:dph, GOC:rb, PMID:15090616] +synonym: "aminophospholipid translocase complex" EXACT [] +synonym: "APLT complex" EXACT [] +synonym: "CDC50-DRS2 complex" NARROW [] +synonym: "CRF1-DNF3 complex" NARROW [] +synonym: "Dnf1-Lem3 complex" NARROW [] +synonym: "Dnf2-Lem3 complex" NARROW [] +synonym: "DNF3-CRF1 complex" NARROW [] +synonym: "DRS2-CDC50 complex" NARROW [] +synonym: "Lem3-Dnf1 complex" NARROW [] +synonym: "Lem3p-Dnf1p complex" NARROW [] +synonym: "P4-ATPase complex" EXACT [] +synonym: "phospholipid flippase complex" EXACT [] +is_a: GO:1990351 ! transporter complex + +[Term] +id: GO:1990532 +name: stress response to nickel ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus." [GOC:kmv, PMID:25330323] +synonym: "response to nickel ion stress" EXACT [] +synonym: "response to nickel toxicity" EXACT [] +synonym: "stress response to nickel" EXACT [] +is_a: GO:0097501 ! stress response to metal ion + +[Term] +id: GO:1990533 +name: Dom34-Hbs1 complex +namespace: cellular_component +def: "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425] +synonym: "Dom34:Hbs1 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990534 +name: thermospermine oxidase activity +namespace: molecular_function +def: "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine." [PMID:24906355] +is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor + +[Term] +id: GO:1990535 +name: neuron projection maintenance +namespace: biological_process +def: "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:kmv, PMID:25359212] +synonym: "axon homeostasis" RELATED [] +synonym: "axon maintenance" RELATED [] +synonym: "neurite maintenance" NARROW [] +synonym: "neuron process maintenance" EXACT [] +synonym: "neuron protrusion maintenance" EXACT [] +synonym: "neuronal cell projection maintenance" EXACT [] +is_a: GO:0106027 ! neuron projection organization + +[Term] +id: GO:1990536 +name: phosphoenolpyruvate transmembrane import into Golgi lumen +namespace: biological_process +def: "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane." [PMID:25195688] +is_a: GO:0089722 ! phosphoenolpyruvate transmembrane transport + +[Term] +id: GO:1990537 +name: mitotic spindle polar microtubule +namespace: cellular_component +def: "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone." [PMID:16079915] +is_a: GO:0005827 ! polar microtubule +is_a: GO:1990498 ! mitotic spindle microtubule + +[Term] +id: GO:1990538 +name: xylan O-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan." [PMID:25141999] +is_a: GO:0016413 ! O-acetyltransferase activity + +[Term] +id: GO:1990539 +name: fructose import across plasma membrane +namespace: biological_process +def: "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] +is_a: GO:0032445 ! fructose import +is_a: GO:0140271 ! hexose import across plasma membrane + +[Term] +id: GO:1990540 +name: mitochondrial manganese ion transmembrane transport +namespace: biological_process +def: "The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12890866] +is_a: GO:0071421 ! manganese ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990542 +name: mitochondrial transmembrane transport +namespace: biological_process +def: "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899] +is_a: GO:0055085 ! transmembrane transport + +[Term] +id: GO:1990543 +name: mitochondrial S-adenosyl-L-methionine transmembrane transport +namespace: biological_process +def: "The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14609944] +is_a: GO:1901962 ! S-adenosyl-L-methionine transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990544 +name: mitochondrial ATP transmembrane transport +namespace: biological_process +def: "The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:18485069] +is_a: GO:0015867 ! ATP transport +is_a: GO:0072530 ! purine-containing compound transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1901679 ! nucleotide transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990545 +name: mitochondrial thiamine pyrophosphate transmembrane transport +namespace: biological_process +def: "The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:12411483] +is_a: GO:0030974 ! thiamine pyrophosphate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990546 +name: mitochondrial tricarboxylic acid transmembrane transport +namespace: biological_process +def: "The process in which a tricarboxylic acid is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw] +is_a: GO:0035674 ! tricarboxylic acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990547 +name: mitochondrial phosphate ion transmembrane transport +namespace: biological_process +def: "The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9099701] +is_a: GO:0035435 ! phosphate ion transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990548 +name: mitochondrial FAD transmembrane transport +namespace: biological_process +def: "The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:14555654] +is_a: GO:0035350 ! FAD transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990549 +name: mitochondrial NAD transmembrane transport +namespace: biological_process +def: "The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:16291748] +is_a: GO:0035352 ! NAD transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990550 +name: mitochondrial alpha-ketoglutarate transmembrane transport +namespace: biological_process +alt_id: GO:1990552 +def: "The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234, PMID:20371607] +synonym: "mitochondrial 2-oxoglutarate transmembrane transport" EXACT [] +is_a: GO:0015742 ! alpha-ketoglutarate transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990551 +name: mitochondrial 2-oxoadipate transmembrane transport +namespace: biological_process +def: "The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11013234] +is_a: GO:0006835 ! dicarboxylic acid transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1905039 ! carboxylic acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990553 +name: mitochondrial 5'-adenylyl sulfate transmembrane transport +namespace: biological_process +def: "The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033] +is_a: GO:1902558 ! 5'-adenylyl sulfate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990554 +name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport +namespace: biological_process +def: "The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:24296033] +is_a: GO:1902559 ! 3'-phospho-5'-adenylyl sulfate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990555 +name: mitochondrial oxaloacetate transmembrane transport +namespace: biological_process +def: "The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] +is_a: GO:1902356 ! oxaloacetate(2-) transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990556 +name: mitochondrial isopropylmalate transmembrane transport +namespace: biological_process +def: "The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] +is_a: GO:1902357 ! 2-isopropylmalate(2-) transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990557 +name: mitochondrial sulfate transmembrane transport +namespace: biological_process +def: "The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] +is_a: GO:1902358 ! sulfate transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990558 +name: mitochondrial malonate(1-) transmembrane transport +namespace: biological_process +def: "The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:10428783] +is_a: GO:1901553 ! malonic acid transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990559 +name: mitochondrial coenzyme A transmembrane transport +namespace: biological_process +def: "The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:11158296] +is_a: GO:0035349 ! coenzyme A transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990560 +name: obsolete DNA methyltransferase binding +namespace: molecular_function +def: "OBSOLETE. Binding to a DNA methyltransferase." [PMID:22880885] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "DNA methyltransferase binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990561 +name: obsolete regulation of transcription from RNA polymerase II promoter in response to copper ion starvation +namespace: biological_process +def: "OBSOLETE. Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions." [GOC:al, PMID:10593913] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true +consider: GO:0006357 +consider: GO:0035874 + +[Term] +id: GO:1990562 +name: syndecan-syntenin-ALIX complex +namespace: cellular_component +def: "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery." [GOC:bhm, PMID:22660413] +comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). +synonym: "exosome complex" BROAD [] +is_a: GO:1990563 ! extracellular exosome complex + +[Term] +id: GO:1990563 +name: extracellular exosome complex +namespace: cellular_component +def: "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome." [GOC:bhm, PMID:22660413] +comment: An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). +synonym: "exosome complex" EXACT [] +synonym: "extracellular vesicular exosome complex" EXACT [GOC:vesicles] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0070062 ! extracellular exosome + +[Term] +id: GO:1990564 +name: protein polyufmylation +namespace: biological_process +def: "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain." [PMID:25219498] +is_a: GO:0071569 ! protein ufmylation + +[Term] +id: GO:1990565 +name: HSP90-CDC37 chaperone complex +namespace: cellular_component +def: "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." [GOC:bhm, GOC:pad, GOC:PARL, PMID:21855797, PMID:22939624] +comment: An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay). +is_a: GO:0101031 ! chaperone complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990566 +name: I(KACh) inward rectifier potassium channel complex +namespace: cellular_component +def: "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits." [GOC:ame, PMID:9765280] +comment: Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence. +synonym: "GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED [] +synonym: "Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex" RELATED [] +synonym: "muscarinic potassium channel complex" RELATED [] +is_a: GO:1902937 ! inward rectifier potassium channel complex + +[Term] +id: GO:1990567 +name: DPS complex +namespace: cellular_component +def: "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22." [PMID:24945319] +is_a: GO:0008287 ! protein serine/threonine phosphatase complex + +[Term] +id: GO:1990568 +name: obsolete MIS18 complex +namespace: cellular_component +def: "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly." [GOC:bhm, PMID:25036634] +comment: An example of this is MIS18A in human (Q9NYP9) in PMID:25036634 (inferred from physical interaction). +synonym: "MIS18 complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990569 +name: UDP-N-acetylglucosamine transmembrane transport +namespace: biological_process +alt_id: GO:0015788 +def: "The process in which UDP-N-acetylglucosamine is transported across a membrane." [PMID:10788474] +synonym: "UDP-N-acetylglucosamine transport" RELATED [] +is_a: GO:0015711 ! organic anion transport +is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport + +[Term] +id: GO:1990570 +name: GDP-mannose transmembrane transport +namespace: biological_process +alt_id: GO:0015784 +def: "The process in which GDP-mannose is transported across a membrane." [PMID:9395539] +synonym: "GDP-mannose transport" RELATED [] +is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport + +[Term] +id: GO:1990571 +name: meiotic centromere clustering +namespace: biological_process +def: "The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I." [PMID:10366596, PMID:9009280] +synonym: "centromere clustering during meiosis" EXACT [] +synonym: "homologous chromosome movement towards spindle pole in meiosis I prometaphase" EXACT [] +is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole +is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle +is_a: GO:0098653 ! centromere clustering + +[Term] +id: GO:1990572 +name: TERT-RMRP complex +namespace: cellular_component +def: "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP)." [GOC:bf, GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19701182] +synonym: "telomerase reverse transcriptase:RMRP RNA complex" EXACT [PMID:19701182] +is_a: GO:0031379 ! RNA-directed RNA polymerase complex +is_a: GO:1990904 ! ribonucleoprotein complex + +[Term] +id: GO:1990573 +name: potassium ion import across plasma membrane +namespace: biological_process +alt_id: GO:0010107 +def: "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127] +synonym: "potassium import" BROAD [] +synonym: "potassium ion import" BROAD [] +synonym: "potassium ion uptake" BROAD [GOC:dph, GOC:tb] +is_a: GO:0071805 ! potassium ion transmembrane transport +is_a: GO:0098659 ! inorganic cation import across plasma membrane + +[Term] +id: GO:1990574 +name: meiotic spindle astral microtubule +namespace: cellular_component +def: "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [PMID:10366596] +is_a: GO:0000235 ! astral microtubule +relationship: part_of GO:0072687 ! meiotic spindle + +[Term] +id: GO:1990575 +name: mitochondrial L-ornithine transmembrane transport +namespace: biological_process +alt_id: GO:0000066 +def: "The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion." [PMID:9237680] +synonym: "mitochondrial ornithine transmembrane transport" BROAD [] +synonym: "mitochondrial ornithine transport" RELATED [] +is_a: GO:1903352 ! L-ornithine transmembrane transport +is_a: GO:1990542 ! mitochondrial transmembrane transport + +[Term] +id: GO:1990576 +name: G protein-coupled glucose receptor activity +namespace: molecular_function +def: "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:15667320] +synonym: "G-protein coupled glucose receptor activity" EXACT [] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:1990577 +name: C-terminal protein demethylation +namespace: biological_process +def: "The removal of a methyl group from the C-terminal amino acid of a protein." [PMID:11060018] +is_a: GO:0006482 ! protein demethylation + +[Term] +id: GO:1990578 +name: perinuclear endoplasmic reticulum membrane +namespace: cellular_component +def: "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus." [PMID:25454947] +synonym: "perinuclear ER membrane" EXACT [] +is_a: GO:0031090 ! organelle membrane +relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network +relationship: part_of GO:0097038 ! perinuclear endoplasmic reticulum + +[Term] +id: GO:1990579 +name: peptidyl-serine trans-autophosphorylation +namespace: biological_process +def: "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:bf, GOC:PARL, PMID:21317875] +synonym: "serine autophosphorylation in trans" EXACT [PMID:21317875] +synonym: "serine transautophosphorylation" EXACT [PMID:21317875] +is_a: GO:0036289 ! peptidyl-serine autophosphorylation +is_a: GO:0036290 ! protein trans-autophosphorylation + +[Term] +id: GO:1990580 +name: regulation of cytoplasmic translational termination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:2000765 ! regulation of cytoplasmic translation +relationship: regulates GO:0002184 ! cytoplasmic translational termination + +[Term] +id: GO:1990581 +name: obsolete lysosome lysis +namespace: biological_process +def: "OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause." [PMID:24472, PMID:9538255] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "lysosomal lysis" EXACT [] +synonym: "lysosome lysis" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990582 +name: obsolete intracellular membrane-bounded organelle binding +namespace: molecular_function +def: "OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle." [PMID:16100119, PMID:9538255] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "intracellular membrane-bounded organelle binding" EXACT [] +synonym: "intracellular membrane-enclosed organelle binding" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990583 +name: phospholipase D activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme phospholipase D." [PMID:7972129] +is_a: GO:0016004 ! phospholipase activator activity + +[Term] +id: GO:1990584 +name: cardiac Troponin complex +namespace: cellular_component +def: "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction." [GOC:ame, PMID:12840750] +synonym: "cTnC:cTnI:cTnT" RELATED [] +is_a: GO:0005861 ! troponin complex + +[Term] +id: GO:1990585 +name: hydroxyproline O-arabinosyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+." [EC:2.4.2.-, PMID:24036508] +synonym: "HPAT" EXACT [] +is_a: GO:0016763 ! pentosyltransferase activity + +[Term] +id: GO:1990586 +name: divisome complex +namespace: cellular_component +def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells." [GOC:bhm, PMID:15165235, PMID:21784946] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030428 ! cell septum + +[Term] +id: GO:1990587 +name: FtsQBL complex +namespace: cellular_component +def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ." [GOC:bhm, PMID:15165235, PMID:21784946] +comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). +synonym: "FtsB-FtsL-FtsQ complex" EXACT [] +is_a: GO:1990586 ! divisome complex + +[Term] +id: GO:1990588 +name: FtsBL complex +namespace: cellular_component +def: "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL." [GOC:bhm, PMID:15165235, PMID:21784946] +comment: An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). +synonym: "FtsB-FtsL complex" EXACT [] +is_a: GO:1990586 ! divisome complex +relationship: part_of GO:0005829 ! cytosol +relationship: part_of GO:1990587 ! FtsQBL complex + +[Term] +id: GO:1990589 +name: ATF4-CREB1 transcription factor complex +namespace: cellular_component +def: "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, PMID:12871976] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990590 +name: ATF1-ATF4 transcription factor complex +namespace: cellular_component +def: "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." [GOC:bhm, PMID:12871976] +comment: An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction). +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990591 +name: asparagine transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of asparagine into the vacuole across the vacuolar membrane." [PMID:20388511] +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +is_a: GO:1903713 ! asparagine transmembrane transport + +[Term] +id: GO:1990592 +name: protein K69-linked ufmylation +namespace: biological_process +def: "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498] +is_a: GO:1990564 ! protein polyufmylation + +[Term] +id: GO:1990593 +name: nascent polypeptide-associated complex binding +namespace: molecular_function +def: "Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:25487825] +synonym: "NAC binding" EXACT [] +synonym: "NACA binding" EXACT [] +is_a: GO:0044877 ! protein-containing complex binding + +[Term] +id: GO:1990594 +name: L-altrarate dehydratase activity +namespace: molecular_function +def: "Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [PMID:17649980] +synonym: "L-talarate dehydratase activity" EXACT [] +xref: RHEA:44028 +is_a: GO:0016836 ! hydro-lyase activity + +[Term] +id: GO:1990595 +name: mast cell secretagogue receptor activity +namespace: molecular_function +def: "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells." [GOC:sp, PMID:25517090] +is_a: GO:0004930 ! G protein-coupled receptor activity + +[Term] +id: GO:1990596 +name: histone H3-K4 deacetylation +namespace: biological_process +def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone." [PMID:20299449] +is_a: GO:0070932 ! histone H3 deacetylation + +[Term] +id: GO:1990597 +name: AIP1-IRE1 complex +namespace: cellular_component +def: "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285] +synonym: "AIP1-ERN1 complex" RELATED [HGNC:3449] +synonym: "IRE1-DAB2IP complex" EXACT [GOC:bf] +synonym: "IRE1alpha-AIP1 complex" NARROW [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990599 +name: 3' overhang single-stranded DNA endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555] +is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity + +[Term] +id: GO:1990600 +name: single-stranded DNA endodeoxyribonuclease activator activity +namespace: molecular_function +def: "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity." [PMID:25203555] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:1990601 +name: 5' overhang single-stranded DNA endodeoxyribonuclease activity +namespace: molecular_function +def: "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555] +is_a: GO:0000014 ! single-stranded DNA endodeoxyribonuclease activity + +[Term] +id: GO:1990602 +name: obsolete importin alpha-subunit nuclear import complex +namespace: cellular_component +def: "OBSOLETE. A trimeric protein complex which functions to transport the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14)." [GOC:bhm, PMID:20122403] +comment: The reason for obsoletion is that these terms include the substrate of the reaction. +synonym: "Cdm-Mago-Tsu complex" NARROW [] +synonym: "Importin13-Mago-Tsu complex" NARROW [] +is_obsolete: true + +[Term] +id: GO:1990603 +name: dark adaptation +namespace: biological_process +def: "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, http://www.ncbi.nlm.nih.gov/books/NBK11525/, ISBN:0198506732] +comment: The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598 +is_a: GO:0071485 ! cellular response to absence of light + +[Term] +id: GO:1990604 +name: IRE1-TRAF2-ASK1 complex +namespace: cellular_component +def: "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344] +synonym: "ERN1-TRAF2-ASK1 complex" RELATED [HGNC:3449] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0005789 ! endoplasmic reticulum membrane + +[Term] +id: GO:1990605 +name: GU repeat RNA binding +namespace: molecular_function +def: "Binding to an RNA molecule containing GU repeats." [PMID:20081200] +is_a: GO:0003723 ! RNA binding + +[Term] +id: GO:1990606 +name: membrane scission GTPase motor activity +namespace: molecular_function +def: "Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis." [PMID:11242086, PMID:23530241, PMID:24515348] +is_a: GO:0061791 ! GTPase motor activity + +[Term] +id: GO:1990607 +name: obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint +namespace: biological_process +def: "OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint." [GOC:mtg_cell_cycle, GOC:vw, PMID:1234] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990608 +name: mitotic spindle pole body localization +namespace: biological_process +alt_id: GO:0070632 +alt_id: GO:0071789 +def: "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location." [PMID:24963130] +synonym: "establishment and maintenance of spindle pole body localization" EXACT [] +synonym: "establishment of spindle pole body localisation" NARROW [GOC:mah] +synonym: "establishment of spindle pole body localization" NARROW [] +synonym: "mitotic spindle pole body localization to nuclear envelope" NARROW [] +synonym: "spindle pole body docking" NARROW [GOC:vw] +synonym: "spindle pole body localisation in nuclear envelope" NARROW [GOC:mah] +synonym: "spindle pole body localization in nuclear envelope" NARROW [] +synonym: "spindle pole body localization to nuclear envelope" NARROW [] +synonym: "spindle pole body positioning" NARROW [GOC:vw] +is_a: GO:0070631 ! spindle pole body localization +is_a: GO:1903047 ! mitotic cell cycle process + +[Term] +id: GO:1990609 +name: glutamate-cysteine ligase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of glutamate-cysteine ligase." [PMID:8103521] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:1990610 +name: acetolactate synthase regulator activity +namespace: molecular_function +def: "Binds to and modulates the activity of acetolactate synthase." [PMID:8972574] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:1990611 +name: regulation of cytoplasmic translational initiation in response to stress +namespace: biological_process +def: "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445] +is_a: GO:0043558 ! regulation of translational initiation in response to stress +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +is_a: GO:1990497 ! regulation of cytoplasmic translation in response to stress + +[Term] +id: GO:1990612 +name: Sad1-Kms1 LINC complex +namespace: cellular_component +def: "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair." [GOC:vw, PMID:24943839, PMID:24947240] +is_a: GO:0034993 ! meiotic nuclear membrane microtubule tethering complex +is_a: GO:1990391 ! DNA repair complex + +[Term] +id: GO:1990613 +name: mitochondrial membrane fusion +namespace: biological_process +def: "The joining of two lipid bilayers that surround the mitochondria." [PMID:12052774] +is_a: GO:0007006 ! mitochondrial membrane organization +is_a: GO:0090174 ! organelle membrane fusion + +[Term] +id: GO:1990615 +name: Kelch-containing formin regulatory complex +namespace: cellular_component +def: "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p." [PMID:24828508] +synonym: "Bud14-Kel1-Kel2 complex" NARROW [] +synonym: "KFRC complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990616 +name: magnesium ion export from mitochondrion +namespace: biological_process +def: "The directed movement of magnesium ions out of mitochondrial matrix into the cytosol by means of some agent such as a transporter or pore." [PMID:25585246] +synonym: "magnesium ion efflux from mitochondrion" EXACT [] +is_a: GO:0045016 ! mitochondrial magnesium ion transmembrane transport +is_a: GO:0070839 ! metal ion export + +[Term] +id: GO:1990617 +name: CHOP-ATF4 complex +namespace: cellular_component +def: "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." [GOC:bf, GOC:PARL, PMID:18940792] +synonym: "ATF4-CHOP heterodimer" EXACT [PMID:18940792] +synonym: "CHOP-ATF4 heterodimer" EXACT [PMID:18940792] +synonym: "CHOP-CREB-2 complex" EXACT [PMID:11478948] +synonym: "CHOP/ATF4 complex" EXACT [PMID:18940792] +synonym: "GADD153-ATF4 complex" EXACT [GOC:bf] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990618 +name: obsolete ANPR-A:ANP complex +namespace: cellular_component +def: "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, PMID:15117952] +comment: An example of this is [ANPR-A:ANP] in [rat] (P18910:P01161-PRO_0000391785) in PMID:15117952 (inferred from direct assay). +synonym: "ANPR-A:ANP complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990619 +name: histone H3-K9 deacetylation +namespace: biological_process +def: "The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone." [PMID:25002536] +is_a: GO:0070932 ! histone H3 deacetylation + +[Term] +id: GO:1990620 +name: ANPR-A receptor complex +namespace: cellular_component +def: "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, PMID:15117952] +comment: An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay). +synonym: "NPR1 receptor complex" RELATED [] +is_a: GO:0043235 ! receptor complex + +[Term] +id: GO:1990621 +name: ESCRT IV complex +namespace: cellular_component +def: "An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:bhm, GOC:ha, PMID:20653365, PMID:20696398, PMID:21925211, PMID:24456136, PMID:25164817, PMID:26775243] +synonym: "ESCRT-IV" EXACT [] +synonym: "vacuolar protein sorting-associated complex" RELATED [] +synonym: "Vps4 complex" RELATED [] +synonym: "Vps4-Vta1 complex" NARROW [] +synonym: "VPS4A-VPS4B" NARROW [] +synonym: "VPS4A/B complex" NARROW [] +synonym: "Vta1-Vps4 complex" RELATED [] +is_a: GO:0036452 ! ESCRT complex +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1904949 ! ATPase complex +relationship: part_of GO:0010008 ! endosome membrane + +[Term] +id: GO:1990622 +name: CHOP-ATF3 complex +namespace: cellular_component +def: "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660] +synonym: "ATF3-CHOP complex" EXACT [GOC:bf] +synonym: "CHOP-ATF3 heterodimer" EXACT [GOC:bf] +synonym: "CHOP-ATF3 heterodimeric complex" EXACT [GOC:bf] +synonym: "GADD153-ATF3 complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990623 +name: Herring body +namespace: cellular_component +def: "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively." [ISBN:0199652473, Wikipedia:Herring_bodies] +synonym: "neurosecretory body" EXACT [] +is_a: GO:0043679 ! axon terminus + +[Term] +id: GO:1990624 +name: guanyl nucleotide exchange factor inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor." [GOC:vw, PMID:25635048] +is_a: GO:0030234 ! enzyme regulator activity + +[Term] +id: GO:1990625 +name: negative regulation of cytoplasmic translational initiation in response to stress +namespace: biological_process +def: "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291] +is_a: GO:0032055 ! negative regulation of translation in response to stress +is_a: GO:0032057 ! negative regulation of translational initiation in response to stress +is_a: GO:1904689 ! negative regulation of cytoplasmic translational initiation +is_a: GO:1990611 ! regulation of cytoplasmic translational initiation in response to stress + +[Term] +id: GO:1990626 +name: mitochondrial outer membrane fusion +namespace: biological_process +def: "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:21385840] +synonym: "mitochondrion outer membrane fusion" EXACT [] +is_a: GO:0007008 ! outer mitochondrial membrane organization +is_a: GO:1990613 ! mitochondrial membrane fusion + +[Term] +id: GO:1990627 +name: mitochondrial inner membrane fusion +namespace: biological_process +def: "The membrane organization process that joins two mitochondrial inner membranes to form a single membrane." [GOC:vw, PMID:17055438] +synonym: "mitochondrion inner membrane fusion" EXACT [] +is_a: GO:0007007 ! inner mitochondrial membrane organization +is_a: GO:1990613 ! mitochondrial membrane fusion + +[Term] +id: GO:1990628 +name: obsolete Sigma-E factor negative regulation complex +namespace: cellular_component +def: "OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell." [GOC:bhm, PMID:20190044] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "RseA-RseB-RpoE complex" RELATED [] +synonym: "Sigma-E factor negative regulation complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990629 +name: phospholamban complex +namespace: cellular_component +def: "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels." [GOC:ame, PMID:16043693] +comment: An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay). +synonym: "cardiac phospholamban complex" EXACT [] +synonym: "cardiac PLB complex" RELATED [] +synonym: "cardiac PLN complex" RELATED [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140534 ! endoplasmic reticulum protein-containing complex +relationship: part_of GO:0033017 ! sarcoplasmic reticulum membrane + +[Term] +id: GO:1990630 +name: IRE1-RACK1-PP2A complex +namespace: cellular_component +def: "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773] +synonym: "ERN1-RACK1-PP2A complex" RELATED [HGNC:3449] +synonym: "IRE1alpha-RACK1-PP2A complex" NARROW [GOC:bf, PMID:20103773] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990631 +name: ErbB-4 class receptor binding +namespace: molecular_function +def: "Binding to the protein-tyrosine kinase receptor ErbB-4/HER4." [GOC:sl, PMID:18523588] +synonym: "HER4 receptor binding" EXACT [] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:1990632 +name: branching involved in submandibular gland morphogenesis +namespace: biological_process +def: "The process in which the branching structure of the submandibular gland is generated and organized." [PMID:15063181, PMID:20890964] +synonym: "submandibular gland branching morphogenesis" EXACT [PMID:20890964] +synonym: "submandibular gland ductal branching" EXACT [PMID:20890964] +is_a: GO:0060445 ! branching involved in salivary gland morphogenesis + +[Term] +id: GO:1990633 +name: mutator focus +namespace: cellular_component +def: "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules." [GOC:kmv, PMID:22713602, PMID:25635455] +is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule +relationship: part_of GO:0048471 ! perinuclear region of cytoplasm + +[Term] +id: GO:1990634 +name: protein phosphatase 5 binding +namespace: molecular_function +def: "Binding to protein phosphatase 5." [PMID:8943293] +synonym: "protein phosphatase T binding" EXACT [] +is_a: GO:0019903 ! protein phosphatase binding + +[Term] +id: GO:1990635 +name: proximal dendrite +namespace: cellular_component +def: "The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma)." [GOC:aruk, GOC:bc, PMID:16899232] +is_a: GO:0030425 ! dendrite + +[Term] +id: GO:1990636 +name: reproductive senescence +namespace: biological_process +def: "A natural reduction in reproductive capacity with aging, often taking the form of a switch from regular reproductive cycles to irregular and infrequent ones." [PMID:24914937, PMID:25523082] +is_a: GO:0010259 ! multicellular organism aging + +[Term] +id: GO:1990637 +name: response to prolactin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation." [PMID:7760850] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1990638 +name: response to granulocyte colony-stimulating factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469] +synonym: "response to G-CSF" EXACT [] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:1990639 +name: obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [PMID:11348594] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "inositol-3,4,5-trisphosphate 5-phosphatase activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990640 +name: inositol-2,4,5-triphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate." [PMID:15316017] +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:1990641 +name: response to iron ion starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." [PMID:16208485] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:1990642 +name: obsolete response to castration +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads." [PMID:11255226] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to castration" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990643 +name: cellular response to granulocyte colony-stimulating factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:1990638 ! response to granulocyte colony-stimulating factor + +[Term] +id: GO:1990644 +name: microtubule site clamp +namespace: molecular_function +def: "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore." [PMID:20723757] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:1990645 +name: obsolete phosphorylase dephosphorylation +namespace: biological_process +def: "OBSOLETE. The modification of phosphorylases by removal of phosphate groups." [PMID:8602837] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "phosphorylase dephosphorylation" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990646 +name: cellular response to prolactin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus." [PMID:7760850] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1990637 ! response to prolactin + +[Term] +id: GO:1990647 +name: C/EBP complex +namespace: cellular_component +def: "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, PMID:8657121] +comment: An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay). +synonym: "C/EBP homodimer complex" EXACT [] +synonym: "C/EBP transcription factor complex" EXACT [] +synonym: "C/EBPalpha complex" NARROW [] +synonym: "C/EBPalpha homodimer complex" NARROW [] +synonym: "C/EBPbeta complex" NARROW [] +synonym: "C/EBPbeta homodimer complex" NARROW [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990648 +name: inositol-4,5,6-triphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate." [GOC:al, PMID:15316017] +is_a: GO:0046030 ! inositol trisphosphate phosphatase activity + +[Term] +id: GO:1990649 +name: inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate." [GOC:al, PMID:15316017] +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:1990650 +name: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." [GOC:al, PMID:15316017] +is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity + +[Term] +id: GO:1990651 +name: inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate." [GOC:al, PMID:15316017] +is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity + +[Term] +id: GO:1990652 +name: obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [PMID:23695302] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990653 +name: obsolete monounsaturated fatty acid biosynthetic process +namespace: biological_process +def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids." [GOC:hjd, PMID:16443825] +comment: For example, stearoyl-coenzyme A desaturase (Scd) catalyzes the desaturation of saturated fatty acids to monounsaturated fatty acids in mammals and yeast. +is_obsolete: true + +[Term] +id: GO:1990654 +name: sebum secreting cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083] +synonym: "sebocyte proliferation" RELATED [GOC:dph] +is_a: GO:0008283 ! cell population proliferation + +[Term] +id: GO:1990655 +name: 4 iron, 3 sulfur cluster binding +namespace: molecular_function +def: "Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria." [GOC:am, PMID:23267108] +synonym: "4Fe-3S cluster binding" RELATED [] +is_a: GO:0051536 ! iron-sulfur cluster binding + +[Term] +id: GO:1990656 +name: t-SNARE clustering +namespace: biological_process +def: "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies." [PMID:22528485] +is_a: GO:0072657 ! protein localization to membrane + +[Term] +id: GO:1990657 +name: iNOS-S100A8/A9 complex +namespace: cellular_component +def: "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine." [GOC:bhm, PMID:25417112] +comment: An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay). +is_a: GO:1903958 ! nitric-oxide synthase complex +is_a: GO:1990658 ! transnitrosylase complex + +[Term] +id: GO:1990658 +name: transnitrosylase complex +namespace: cellular_component +def: "A transferase complex which is capable of transferring nitrogenous groups from one component to another." [GOC:bhm, PMID:25417112] +comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). +synonym: "transferase complex, transferring nitrogenous groups" EXACT [] +is_a: GO:1990234 ! transferase complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990659 +name: sequestering of manganese ion +namespace: biological_process +def: "The process of binding or confining manganese ions such that they are separated from other components of a biological system." [GOC:bhm, PMID:25417112] +comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). +synonym: "manganese ion retention" EXACT [] +synonym: "manganese ion sequestering" EXACT [] +synonym: "manganese ion sequestration" EXACT [] +synonym: "manganese ion storage" EXACT [] +synonym: "retention of manganese ion" EXACT [] +synonym: "sequestration of manganese ion" EXACT [] +synonym: "storage of manganese ion" EXACT [] +is_a: GO:0051238 ! sequestering of metal ion +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0030026 ! cellular manganese ion homeostasis + +[Term] +id: GO:1990660 +name: calprotectin complex +namespace: cellular_component +def: "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, PMID:25417112] +comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). +synonym: "calprotectin heterodimer" NARROW [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990661 +name: S100A8 complex +namespace: cellular_component +def: "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4)." [GOC:bhm, PMID:25417112] +comment: An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay). +synonym: "S100A8 homodimer" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990662 +name: S100A9 complex +namespace: cellular_component +def: "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility." [GOC:bhm, PMID:15642721] +comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay). +synonym: "S100A9 homodimer" EXACT [] +is_a: GO:1902495 ! transmembrane transporter complex + +[Term] +id: GO:1990663 +name: dihydroorotate dehydrogenase (fumarate) activity +namespace: molecular_function +def: "Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate." [PMID:1409592, RHEA:30059] +xref: EC:1.3.98.1 +xref: RHEA:30059 +is_a: GO:0004152 ! dihydroorotate dehydrogenase activity + +[Term] +id: GO:1990664 +name: Nkx-2.5 complex +namespace: cellular_component +def: "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes." [GOC:ame, PMID:22849347] +comment: An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay). +synonym: "Nkx-2.5 homodimer complex" NARROW [] +synonym: "NKX.2-5 homodimer complex" RELATED [] +synonym: "NKX2.5 complex" RELATED [] +synonym: "NKX2E homodimer complex" RELATED [] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990665 +name: AnxA2-p11 complex +namespace: cellular_component +def: "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10)." [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454] +synonym: "(A2.p11)2 complex" EXACT [PMID:23483454] +synonym: "(p11)2.(AnxA2)2 complex" EXACT [PMID:18799458] +synonym: "Annexin A2 tetramer" RELATED [PMID:23483454] +synonym: "Annexin A2-p11 complex" EXACT [GOC:bf] +synonym: "AnxA2.p11 complex" EXACT [PMID:18799458] +synonym: "AnxA2:S100A10 heterotetramer" EXACT [PMID:23483454] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990666 +name: PCSK9-LDLR complex +namespace: cellular_component +def: "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway." [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079] +synonym: "PCSK9.LDLR complex" EXACT [PMID:18799458] +synonym: "PCSK9/LDL-R complex" EXACT [PMID:24440079] +synonym: "PCSK9:EGF-A complex" RELATED [PMID:18250299] +synonym: "PCSK9:low-density lipoprotein receptor complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990667 +name: PCSK9-AnxA2 complex +namespace: cellular_component +def: "A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2)." [GOC:BHF, GOC:nc, PMID:22848640] +synonym: "PCSK9-Annexin A2 complex" EXACT [GOC:bf] +synonym: "PCSK9.AnxA2 complex" EXACT [PMID:18799458] +synonym: "PCSK9:ANXA2 complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990668 +name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] +synonym: "vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane" EXACT [] +synonym: "vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] +synonym: "vesicle fusion with ERGIC membrane" EXACT [] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:1990669 +name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane" EXACT [] +synonym: "ER-Golgi intermediate compartment derived vesicle fusion with ER membrane" EXACT [] +is_a: GO:0048279 ! vesicle fusion with endoplasmic reticulum +relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum + +[Term] +id: GO:1990670 +name: vesicle fusion with Golgi cis cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] +is_a: GO:0006906 ! vesicle fusion + +[Term] +id: GO:1990671 +name: vesicle fusion with Golgi medial cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662] +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus + +[Term] +id: GO:1990672 +name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +is_a: GO:0048210 ! Golgi vesicle fusion to target membrane +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus +relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport + +[Term] +id: GO:1990673 +name: intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +namespace: cellular_component +def: "The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "intrinsic component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:0033116 ! endoplasmic reticulum-Golgi intermediate compartment membrane + +[Term] +id: GO:1990674 +name: Golgi cis cisterna membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "cis-Golgi cisterna membrane" EXACT [] +is_a: GO:0032580 ! Golgi cisterna membrane +relationship: part_of GO:0000137 ! Golgi cis cisterna + +[Term] +id: GO:1990675 +name: Golgi medial cisterna membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "medial-Golgi cisterna membrane" EXACT [] +is_a: GO:0032580 ! Golgi cisterna membrane +relationship: part_of GO:0005797 ! Golgi medial cisterna + +[Term] +id: GO:1990676 +name: Golgi trans cisterna membrane +namespace: cellular_component +def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "trans-Golgi cisterna membrane" EXACT [] +is_a: GO:0032580 ! Golgi cisterna membrane +relationship: part_of GO:0000138 ! Golgi trans cisterna + +[Term] +id: GO:1990677 +name: mitochondrial inner membrane assembly complex +namespace: cellular_component +def: "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion." [GOC:bhm, PMID:24942160] +comment: An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.). +synonym: "INAC complex" EXACT [] +synonym: "inner membrane assembly complex" BROAD [] +synonym: "mitochondrion inner membrane assembly complex" EXACT [] +is_a: GO:0098800 ! inner mitochondrial membrane protein complex + +[Term] +id: GO:1990678 +name: histone H4-K16 deacetylation +namespace: biological_process +def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone." [PMID:17446861] +is_a: GO:0070933 ! histone H4 deacetylation + +[Term] +id: GO:1990679 +name: histone H4-K12 deacetylation +namespace: biological_process +def: "The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone." [PMID:17446861] +is_a: GO:0070933 ! histone H4 deacetylation + +[Term] +id: GO:1990680 +name: response to melanocyte-stimulating hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates." [PMID:17036007] +synonym: "response to MSH" EXACT [] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1990682 +name: CSF1-CSF1R complex +namespace: cellular_component +def: "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand." [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797] +synonym: "CSF1:C-FMS complex" EXACT [HGNC:2432, HGNC:2433] +synonym: "M-CSF:C-FMS complex" RELATED [GOC:nc] +synonym: "M-CSF:CSF1R complex" RELATED [HGNC:2432, HGNC:2433] +synonym: "M-CSF:FMS complex" EXACT [PMID:19017797] +synonym: "macrophage colony-stimulating factor:receptor complex" EXACT [GOC:bf] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990683 +name: DNA double-strand break attachment to nuclear envelope +namespace: biological_process +def: "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs." [PMID:24943839] +is_a: GO:0097240 ! chromosome attachment to the nuclear envelope + +[Term] +id: GO:1990684 +name: protein-lipid-RNA complex +namespace: cellular_component +def: "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634] +comment: Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. +synonym: "miRNA-lipoprotein complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990685 +name: HDL-containing protein-lipid-RNA complex +namespace: cellular_component +def: "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:23559634] +comment: Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs. +is_a: GO:1990684 ! protein-lipid-RNA complex + +[Term] +id: GO:1990686 +name: LDL-containing protein-lipid-RNA complex +namespace: cellular_component +def: "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:23559634] +comment: Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. +is_a: GO:1990684 ! protein-lipid-RNA complex + +[Term] +id: GO:1990687 +name: endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] +synonym: "ER-derived vesicle fusion with ERGIC membrane" EXACT [] +is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:1990688 +name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "Golgi vesicle fusion with ER-Golgi intermediate compartment membrane" EXACT [] +synonym: "Golgi vesicle fusion with ERGIC membrane" EXACT [] +is_a: GO:1990668 ! vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +relationship: part_of GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum + +[Term] +id: GO:1990689 +name: endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] +synonym: "ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] +synonym: "ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane" EXACT [] +synonym: "ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] +synonym: "ERGIC-derived vesicle fusion with Golgi cis cisterna membrane" EXACT [] +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus +is_a: GO:1990670 ! vesicle fusion with Golgi cis cisterna membrane +relationship: part_of GO:0006888 ! endoplasmic reticulum to Golgi vesicle-mediated transport + +[Term] +id: GO:1990690 +name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane" EXACT [] +is_a: GO:0048210 ! Golgi vesicle fusion to target membrane +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus +relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi + +[Term] +id: GO:1990691 +name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT [] +is_a: GO:0048210 ! Golgi vesicle fusion to target membrane +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus +relationship: part_of GO:0048219 ! inter-Golgi cisterna vesicle-mediated transport + +[Term] +id: GO:1990692 +name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane +namespace: biological_process +def: "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane" EXACT [] +is_a: GO:0048210 ! Golgi vesicle fusion to target membrane +is_a: GO:0048280 ! vesicle fusion with Golgi apparatus +relationship: part_of GO:0000301 ! retrograde transport, vesicle recycling within Golgi + +[Term] +id: GO:1990693 +name: intrinsic component of Golgi cis cisterna membrane +namespace: cellular_component +def: "The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "intrinsic component of cis-Golgi cisterna membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:1990674 ! Golgi cis cisterna membrane + +[Term] +id: GO:1990694 +name: intrinsic component of Golgi medial cisterna membrane +namespace: cellular_component +def: "The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "intrinsic component of medial-Golgi cisterna membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:1990675 ! Golgi medial cisterna membrane + +[Term] +id: GO:1990695 +name: intrinsic component of Golgi trans cisterna membrane +namespace: cellular_component +def: "The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "intrinsic component of trans-Golgi cisterna membrane" EXACT [] +is_a: GO:0031300 ! intrinsic component of organelle membrane +relationship: part_of GO:1990676 ! Golgi trans cisterna membrane + +[Term] +id: GO:1990696 +name: USH2 complex +namespace: cellular_component +def: "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7." [GOC:krc, PMID:25406310] +synonym: "USH2 quaternary protein complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990697 +name: protein depalmitoleylation +namespace: biological_process +def: "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein." [PMID:25731175] +is_a: GO:0035601 ! protein deacylation +is_a: GO:0042159 ! lipoprotein catabolic process + +[Term] +id: GO:1990698 +name: palmitoleoyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175] +is_a: GO:0016747 ! acyltransferase activity, transferring groups other than amino-acyl groups + +[Term] +id: GO:1990699 +name: palmitoleyl hydrolase activity +namespace: molecular_function +def: "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate." [PMID:25731175] +is_a: GO:0052689 ! carboxylic ester hydrolase activity + +[Term] +id: GO:1990700 +name: nucleolar chromatin organization +namespace: biological_process +def: "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] +synonym: "establishment or maintenance of nucleolar chromatin architecture" EXACT [] +synonym: "nucleolar chromatin organisation" EXACT [] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0006325 ! chromatin organization +relationship: part_of GO:0007000 ! nucleolus organization + +[Term] +id: GO:1990701 +name: integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane +namespace: cellular_component +def: "The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "integral component of endoplasmic reticulum-Golgi intermediate compartment membrane" EXACT [] +synonym: "integral component of ER-Golgi intermediate compartment membrane" EXACT [] +synonym: "integral component of ERGIC membrane" EXACT [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:1990673 ! intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane + +[Term] +id: GO:1990702 +name: integral component of Golgi cis cisterna membrane +namespace: cellular_component +def: "The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "integral component of cis-Golgi cisterna membrane" EXACT [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:1990693 ! intrinsic component of Golgi cis cisterna membrane + +[Term] +id: GO:1990703 +name: integral component of Golgi medial cisterna membrane +namespace: cellular_component +def: "The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "integral component of medial-Golgi cisterna membrane" EXACT [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:1990694 ! intrinsic component of Golgi medial cisterna membrane + +[Term] +id: GO:1990704 +name: integral component of Golgi trans cisterna membrane +namespace: cellular_component +def: "The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662] +synonym: "integral component of trans-Golgi cisterna membrane" EXACT [] +is_a: GO:0031301 ! integral component of organelle membrane +is_a: GO:1990695 ! intrinsic component of Golgi trans cisterna membrane + +[Term] +id: GO:1990705 +name: cholangiocyte proliferation +namespace: biological_process +def: "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010] +synonym: "hepatoblast proliferation" EXACT [] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:1990706 +name: MAD1 complex +namespace: cellular_component +def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)." [GOC:bhm, intAct:EBI-10691224, PMID:22493223, PMID:22898774] +synonym: "MAD1 homodimer" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990708 +name: conditioned place preference +namespace: biological_process +def: "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821] +is_a: GO:0008306 ! associative learning + +[Term] +id: GO:1990709 +name: presynaptic active zone organization +namespace: biological_process +def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone." [GOC:pr, PMID:16865347, PMID:17068967] +synonym: "presynaptic active zone organisation" EXACT [] +is_a: GO:0016043 ! cellular component organization +relationship: part_of GO:0050808 ! synapse organization + +[Term] +id: GO:1990710 +name: MutS complex +namespace: cellular_component +def: "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations." [GOC:bhm, PMID:21666597] +comment: An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction). +synonym: "MutS mismatch repair complex" EXACT [] +is_a: GO:0032300 ! mismatch repair complex +is_a: GO:1902494 ! catalytic complex + +[Term] +id: GO:1990711 +name: beta-catenin-ICAT complex +namespace: cellular_component +def: "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex." [GOC:bhm, PMID:12408824] +comment: An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction). +synonym: "CTNNB1-CTNNBIP1 complex" EXACT [] +is_a: GO:0090571 ! RNA polymerase II transcription repressor complex + +[Term] +id: GO:1990712 +name: HFE-transferrin receptor complex +namespace: cellular_component +def: "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription." [GOC:BHF, GOC:kom, PMID:25147378] +is_a: GO:0098802 ! plasma membrane signaling receptor complex + +[Term] +id: GO:1990713 +name: survivin complex +namespace: cellular_component +def: "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, PMID:10949038] +comment: An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction). +synonym: "Baculoviral IAP repeat-containing protein 5 complex" EXACT [] +synonym: "survivin homodimer complex" NARROW [] +is_a: GO:0140513 ! nuclear protein-containing complex + +[Term] +id: GO:1990714 +name: hydroxyproline O-galactosyltransferase activity +namespace: molecular_function +def: "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone." [PMID:25600942] +synonym: "HPGT" EXACT [] +is_a: GO:0008378 ! galactosyltransferase activity + +[Term] +id: GO:1990715 +name: mRNA CDS binding +namespace: molecular_function +def: "Binding to an mRNA molecule coding sequence (CDS)." [GOC:kmv, PMID:25805859, SO:0000316] +synonym: "mRNA coding region binding" EXACT [] +synonym: "mRNA coding sequence binding" EXACT [] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:1990716 +name: axonemal central apparatus +namespace: cellular_component +def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005930 ! axoneme + +[Term] +id: GO:1990717 +name: axonemal central bridge +namespace: cellular_component +def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:1990716 ! axonemal central apparatus + +[Term] +id: GO:1990718 +name: axonemal central pair projection +namespace: cellular_component +def: "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:1990716 ! axonemal central apparatus + +[Term] +id: GO:1990719 +name: C1 axonemal microtubule +namespace: cellular_component +def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] +synonym: "C1 tubule" BROAD [] +is_a: GO:0005879 ! axonemal microtubule +relationship: part_of GO:0097540 ! axonemal central pair + +[Term] +id: GO:1990720 +name: C2 axonemal microtubule +namespace: cellular_component +def: "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136] +synonym: "C2 tubule" BROAD [] +is_a: GO:0005879 ! axonemal microtubule +relationship: part_of GO:0097540 ! axonemal central pair + +[Term] +id: GO:1990721 +name: obsolete prostatic acid phosphatase complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP." [GOC:bhm, PMID:12525165] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "ACPP homodimer complex" NARROW [] +synonym: "PAP complex" EXACT [] +synonym: "prostatic acid phosphatase complex" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990722 +name: DAPK1-calmodulin complex +namespace: cellular_component +def: "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding." [GOC:bhm, PMID:20103772] +synonym: "death-associated protein kinase 1 - calmodulin complex" EXACT [] +is_a: GO:1902554 ! serine/threonine protein kinase complex + +[Term] +id: GO:1990723 +name: cytoplasmic periphery of the nuclear pore complex +namespace: cellular_component +def: "Cytoplasm situated in close proximity to a nuclear pore complex." [PMID:9398662] +synonym: "associated with the nuclear pore" RELATED [GOC:mah] +is_a: GO:0048471 ! perinuclear region of cytoplasm + +[Term] +id: GO:1990724 +name: galectin complex +namespace: cellular_component +def: "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes." [GOC:bhm, PMID:15476813, PMID:18777589, PMID:8262940] +comment: An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction). +synonym: "galectin-1 complex" NARROW [] +synonym: "galectin-2 complex" NARROW [] +is_a: GO:0098635 ! protein complex involved in cell-cell adhesion + +[Term] +id: GO:1990725 +name: cord factor receptor activity +namespace: molecular_function +def: "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, PMID:23602766] +synonym: "TMD receptor activity" EXACT [] +synonym: "trehalose 6,6'-dimycolate receptor activity" EXACT [] +xref: Wikipedia:Cord_factor +is_a: GO:0038023 ! signaling receptor activity + +[Term] +id: GO:1990726 +name: Lsm1-7-Pat1 complex +namespace: cellular_component +def: "A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway." [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202] +is_a: GO:0120114 ! Sm-like protein family complex + +[Term] +id: GO:1990727 +name: tubulin folding cofactor complex +namespace: cellular_component +def: "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur." [GOC:vw, PMID:12445400] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990728 +name: mitotic spindle assembly checkpoint MAD1-MAD2 complex +namespace: cellular_component +def: "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, PMID:12006501, PMID:22898774] +comment: An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction). +synonym: "MAD1-MAD2 complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990729 +name: primary miRNA modification +namespace: biological_process +def: "The covalent alteration of one or more nucleotides within a primary miRNA molecule to produce a primary miRNA molecule with a sequence that differs from that coded genetically." [PMID:25799998] +is_a: GO:0009451 ! RNA modification +is_a: GO:0031053 ! primary miRNA processing + +[Term] +id: GO:1990730 +name: VCP-NSFL1C complex +namespace: cellular_component +def: "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505] +synonym: "p97-p47 complex" EXACT [GOC:bf, PMID:12847084] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990731 +name: UV-damage excision repair, DNA incision +namespace: biological_process +def: "A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [PMID:10704216] +synonym: "alternative excision repair, DNA incision" RELATED [PMID:10704216] +synonym: "DNA incision involved in AER" RELATED [PMID:10704216] +synonym: "DNA incision involved in alternative excision repair" RELATED [PMID:10704216] +synonym: "DNA incision involved in UV-damage excision repair" EXACT [] +synonym: "DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair" EXACT [] +synonym: "DNA incision involved in UVDE-dependent excision repair" EXACT [] +synonym: "DNA incision involved in UVER" EXACT [] +synonym: "nucleic acid cleavage involved in UV-damage excision repair" EXACT [] +synonym: "UV-damaged DNA endonuclease-dependent excision repair, DNA incision" EXACT [] +synonym: "UVDE-dependent excision repair, DNA incision" EXACT [] +is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis +relationship: part_of GO:0070914 ! UV-damage excision repair + +[Term] +id: GO:1990732 +name: pyrenoid +namespace: cellular_component +def: "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation." [GOC:cjm, GOC:pr, PMID:23345319, Wikipedia:Pyrenoid] +xref: Wikipedia:Pyrenoid +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0009536 ! plastid + +[Term] +id: GO:1990733 +name: titin-telethonin complex +namespace: cellular_component +def: "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils." [GOC:ame, PMID:16407954] +comment: An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay). +synonym: "Titin-Tcap complex" RELATED [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0030018 ! Z disc + +[Term] +id: GO:1990734 +name: astral microtubule anchoring at mitotic spindle pole body +namespace: biological_process +def: "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232] +is_a: GO:0034631 ! microtubule anchoring at spindle pole body + +[Term] +id: GO:1990735 +name: gamma-tubulin complex localization to mitotic spindle pole body +namespace: biological_process +def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156] +synonym: "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body" EXACT [] +synonym: "gamma-tubulin complex localisation to mitotic spindle pole body" EXACT [] +synonym: "gamma-tubulin complex localization to mitotic SPB" EXACT [] +is_a: GO:0033566 ! gamma-tubulin complex localization + +[Term] +id: GO:1990736 +name: regulation of vascular associated smooth muscle cell membrane depolarization +namespace: biological_process +def: "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763] +synonym: "regulation of vascular smooth muscle cell membrane depolarization" EXACT [] +is_a: GO:0051899 ! membrane depolarization + +[Term] +id: GO:1990737 +name: response to manganese-induced endoplasmic reticulum stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus." [GOC:bf, GOC:PARL, PMID:23934647] +synonym: "manganese-induced ER stress response" EXACT [GOC:bf] +synonym: "response to manganese-induced ER stress" EXACT [GOC:bf] +synonym: "response to Mn-induced ER stress" EXACT [PMID:23934647] +is_a: GO:0034976 ! response to endoplasmic reticulum stress +is_a: GO:0062197 ! cellular response to chemical stress +is_a: GO:0071287 ! cellular response to manganese ion + +[Term] +id: GO:1990738 +name: pseudouridine 5'-phosphatase activity +namespace: molecular_function +def: "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631] +xref: EC:3.1.3.96 +xref: RHEA:10944 +is_a: GO:0016791 ! phosphatase activity + +[Term] +id: GO:1990739 +name: granulosa cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:1990740 +name: obsolete non-selective anion channel activity +namespace: molecular_function +def: "OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions] +comment: This term was made obsolete because it was added in error. +synonym: "nonselective anion channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990741 +name: obsolete non-selective cation channel activity +namespace: molecular_function +def: "OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions] +comment: This term was made obsolete because it was added in error. +synonym: "nonselective cation channel activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990742 +name: microvesicle +namespace: cellular_component +def: "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm." [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles] +synonym: "ectosome" EXACT [PMID:25683921] +synonym: "extracellular microvesicle" EXACT [] +synonym: "shedding vesicle" BROAD [] +is_a: GO:1903561 ! extracellular vesicle + +[Term] +id: GO:1990743 +name: protein sialylation +namespace: biological_process +def: "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein." [PMID:21930713] +is_a: GO:0006464 ! cellular protein modification process +is_a: GO:0097503 ! sialylation + +[Term] +id: GO:1990744 +name: primary miRNA methylation +namespace: biological_process +def: "The posttranscriptional addition of methyl groups to specific residues in an primary miRNA molecule." [PMID:25799998] +is_a: GO:0001510 ! RNA methylation +is_a: GO:1990729 ! primary miRNA modification + +[Term] +id: GO:1990745 +name: EARP complex +namespace: cellular_component +def: "A quatrefoil tethering complex required for endocytic recycling." [PMID:25799061] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0055037 ! recycling endosome + +[Term] +id: GO:1990747 +name: pancreatic trypsinogen secretion +namespace: biological_process +def: "The regulated release of trypsinogen from the cells of the exocrine pancreas." [PMID:12771515] +synonym: "pancreatic trypsinogen release" EXACT [] +is_a: GO:0009306 ! protein secretion +relationship: part_of GO:0030157 ! pancreatic juice secretion + +[Term] +id: GO:1990748 +name: cellular detoxification +namespace: biological_process +def: "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw] +is_a: GO:0009987 ! cellular process +is_a: GO:0098754 ! detoxification +relationship: part_of GO:0097237 ! cellular response to toxic substance + +[Term] +id: GO:1990749 +name: polynucleotide adenylyltransferase activator activity +namespace: molecular_function +def: "Increases the activity of the enzyme polynucleotide adenylyltransferase." [GOC:kmv, PMID:19460348] +is_a: GO:0008047 ! enzyme activator activity + +[Term] +id: GO:1990750 +name: obsolete axon shaft +namespace: cellular_component +def: "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites." [PMID:11264310, PMID:24312009] +comment: This term was made obsolete because it was added in error. +synonym: "axonal shaft" EXACT [] +is_obsolete: true +consider: GO:0044304 + +[Term] +id: GO:1990751 +name: Schwann cell chemotaxis +namespace: biological_process +def: "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995] +is_a: GO:0036135 ! Schwann cell migration +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:1990752 +name: microtubule end +namespace: cellular_component +def: "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr] +comment: This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'. +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005874 ! microtubule + +[Term] +id: GO:1990753 +name: equatorial cell cortex +namespace: cellular_component +def: "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression." [GOC:kmv, PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168] +is_a: GO:0099738 ! cell cortex region +relationship: part_of GO:0032153 ! cell division site + +[Term] +id: GO:1990754 +name: obsolete GABAergic neuronal action potential +namespace: biological_process +def: "OBSOLETE. An action potential that occurs in a GABAergic neuron." [PMID:16921370] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "GABAergic neuronal action potential" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990755 +name: mitotic spindle microtubule depolymerization +namespace: biological_process +def: "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718] +synonym: "mitotic spindle microtubule depolymerisation" EXACT [] +is_a: GO:0007019 ! microtubule depolymerization + +[Term] +id: GO:1990756 +name: ubiquitin ligase-substrate adaptor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274] +synonym: "protein binding, bridging involved in substrate recognition for ubiquitination" EXACT [] +synonym: "ubiquitin ligase substrate adaptor" EXACT [] +is_a: GO:0030674 ! protein-macromolecule adaptor activity + +[Term] +id: GO:1990757 +name: ubiquitin ligase activator activity +namespace: molecular_function +alt_id: GO:0061636 +def: "Binds to and increases the activity of a ubiquitin ligase." [GOC:dph, PMID:25619242] +synonym: "mitotic anaphase-promoting complex activator activity" NARROW [] +is_a: GO:0097027 ! ubiquitin-protein transferase activator activity + +[Term] +id: GO:1990758 +name: mitotic sister chromatid biorientation +namespace: biological_process +def: "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression." [PMID:15309047, PMID:26258632, PMID:26705896] +is_a: GO:0031134 ! sister chromatid biorientation +is_a: GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore + +[Term] +id: GO:1990760 +name: osmolarity-sensing cation channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides." [PMID:18279313] +is_a: GO:0005034 ! osmosensor activity +is_a: GO:0005261 ! cation channel activity +is_a: GO:0022836 ! gated channel activity + +[Term] +id: GO:1990761 +name: growth cone lamellipodium +namespace: cellular_component +def: "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments." [GOC:dos, PMID:25598228] +is_a: GO:0030027 ! lamellipodium +is_a: GO:0043005 ! neuron projection +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:1990762 +name: cytoplasmic alanyl-tRNA aminoacylation +namespace: biological_process +def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation." [GOC:vw] +is_a: GO:0006419 ! alanyl-tRNA aminoacylation +relationship: part_of GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:1990763 +name: arrestin family protein binding +namespace: molecular_function +def: "Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors." [PMID:23911909] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:1990764 +name: myofibroblast contraction +namespace: biological_process +def: "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast." [PMID:19239477] +synonym: "MF contraction" EXACT [] +synonym: "MFB contraction" EXACT [] +is_a: GO:0070252 ! actin-mediated cell contraction + +[Term] +id: GO:1990765 +name: colon smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253] +is_a: GO:0006939 ! smooth muscle contraction +relationship: part_of GO:0014827 ! intestine smooth muscle contraction + +[Term] +id: GO:1990767 +name: prostaglandin receptor internalization +namespace: biological_process +def: "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle." [PMID:15937517] +is_a: GO:0002031 ! G protein-coupled receptor internalization + +[Term] +id: GO:1990768 +name: gastric mucosal blood circulation +namespace: biological_process +def: "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413] +synonym: "stomach mucosal blood circulation" EXACT [] +is_a: GO:0008015 ! blood circulation + +[Term] +id: GO:1990769 +name: proximal neuron projection +namespace: cellular_component +def: "The portion of an axon or dendrite that is close to the neuronal cell body." [PMID:21104189] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:1990770 +name: small intestine smooth muscle contraction +namespace: biological_process +def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626] +is_a: GO:0006939 ! smooth muscle contraction +relationship: part_of GO:0014827 ! intestine smooth muscle contraction + +[Term] +id: GO:1990771 +name: clathrin-dependent extracellular exosome endocytosis +namespace: biological_process +def: "The clathrin-mediated endocytosis of an extracellular exosome." [PMID:24951588] +synonym: "clathrin-mediated extracellular exosome endocytosis" EXACT [] +synonym: "exosome related" EXACT [] +is_a: GO:0051650 ! establishment of vesicle localization +is_a: GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:1990772 +name: substance P secretion +namespace: biological_process +def: "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity." [PMID:11278900] +is_a: GO:0030072 ! peptide hormone secretion + +[Term] +id: GO:1990773 +name: matrix metallopeptidase secretion +namespace: biological_process +def: "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins." [PMID:8679543] +synonym: "matrix metalloproteinase secretion" NARROW [] +synonym: "MMP secretion" EXACT [] +is_a: GO:0009306 ! protein secretion + +[Term] +id: GO:1990775 +name: endothelin production +namespace: biological_process +def: "The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120] +subset: gocheck_do_not_annotate +synonym: "EDN1 production" NARROW [] +synonym: "EDN2 production" NARROW [] +synonym: "EDN3 production" NARROW [] +synonym: "endothelin secretion" NARROW [] +synonym: "endothelin-1 secretion" NARROW [] +synonym: "endothelin-2 production" NARROW [] +synonym: "endothelin-3 production" NARROW [] +is_a: GO:0001816 ! cytokine production + +[Term] +id: GO:1990776 +name: response to angiotensin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [PMID:22982863] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1990777 +name: lipoprotein particle +namespace: cellular_component +def: "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles] +is_a: GO:0032994 ! protein-lipid complex + +[Term] +id: GO:1990778 +name: protein localization to cell periphery +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] +is_a: GO:0034613 ! cellular protein localization + +[Term] +id: GO:1990779 +name: glycoprotein Ib-IX-V complex +namespace: cellular_component +def: "A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation." [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919] +comment: An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay). +synonym: "CD42" EXACT [] +synonym: "GPIb-IX-V complex" EXACT [] +synonym: "GPIb-V-IX complex" EXACT [] +is_a: GO:0090665 ! glycoprotein complex +is_a: GO:0098802 ! plasma membrane signaling receptor complex +relationship: part_of GO:0005887 ! integral component of plasma membrane + +[Term] +id: GO:1990780 +name: cytoplasmic side of dendritic spine plasma membrane +namespace: cellular_component +def: "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine." [PMID:9275233] +is_a: GO:0009898 ! cytoplasmic side of plasma membrane +relationship: part_of GO:0032591 ! dendritic spine membrane + +[Term] +id: GO:1990781 +name: response to immobilization stress combined with electrical stimulus +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile." [PMID:17008368] +is_a: GO:0035902 ! response to immobilization stress +is_a: GO:0051602 ! response to electrical stimulus + +[Term] +id: GO:1990782 +name: protein tyrosine kinase binding +namespace: molecular_function +def: "Binding to protein tyrosine kinase." [PMID:25499537] +synonym: "tyrosine kinase binding" EXACT [] +is_a: GO:0019901 ! protein kinase binding + +[Term] +id: GO:1990783 +name: periphagosomal region of cytoplasm +namespace: cellular_component +def: "Cytoplasm situated near, or occurring around, a phagosome." [PMID:18250451] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + +[Term] +id: GO:1990784 +name: response to dsDNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633] +synonym: "response to double-stranded DNA" EXACT [] +is_a: GO:0014070 ! response to organic cyclic compound +is_a: GO:1901698 ! response to nitrogen compound + +[Term] +id: GO:1990785 +name: response to water-immersion restraint stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile." [PMID:10882227] +synonym: "response to immobilization stress combined with water immersion" EXACT [] +is_a: GO:0035902 ! response to immobilization stress + +[Term] +id: GO:1990786 +name: cellular response to dsDNA +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633] +is_a: GO:0071407 ! cellular response to organic cyclic compound +is_a: GO:1901699 ! cellular response to nitrogen compound +is_a: GO:1990784 ! response to dsDNA + +[Term] +id: GO:1990787 +name: negative regulation of hh target transcription factor activity +namespace: biological_process +def: "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling." [GOC:bhm, PMID:24311597] +synonym: "negative regulation of hedgehog target transcription factor" EXACT [] +is_a: GO:0045879 ! negative regulation of smoothened signaling pathway +is_a: GO:0051090 ! regulation of DNA-binding transcription factor activity + +[Term] +id: GO:1990788 +name: GLI-SUFU complex +namespace: cellular_component +def: "A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, PMID:24311597] +comment: An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:1990789 +name: thyroid gland epithelial cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population." [PMID:17646383] +synonym: "Hurthle cell proliferation" NARROW [] +synonym: "thyroid follicular cell proliferation" NARROW [] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0030878 ! thyroid gland development + +[Term] +id: GO:1990790 +name: response to glial cell derived neurotrophic factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310] +synonym: "response to astrocyte-derived trophic factor" EXACT [] +synonym: "response to ATF" EXACT [] +synonym: "response to GDNF" EXACT [] +is_a: GO:0009719 ! response to endogenous stimulus +is_a: GO:0070848 ! response to growth factor + +[Term] +id: GO:1990791 +name: dorsal root ganglion development +namespace: biological_process +def: "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150] +synonym: "DRG development" EXACT [] +is_a: GO:0061548 ! ganglion development + +[Term] +id: GO:1990792 +name: cellular response to glial cell derived neurotrophic factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310] +synonym: "cellular response to astrocyte-derived trophic factor" EXACT [] +synonym: "cellular response to ATF" EXACT [] +synonym: "cellular response to GDNF" EXACT [] +is_a: GO:0071363 ! cellular response to growth factor stimulus +is_a: GO:0071495 ! cellular response to endogenous stimulus +is_a: GO:1990790 ! response to glial cell derived neurotrophic factor + +[Term] +id: GO:1990793 +name: substance P secretion, neurotransmission +namespace: biological_process +def: "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter." [PMID:15292051] +is_a: GO:0007269 ! neurotransmitter secretion +is_a: GO:1990772 ! substance P secretion + +[Term] +id: GO:1990794 +name: basolateral part of cell +namespace: cellular_component +def: "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells." [PMID:18495799] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0045178 ! basal part of cell +relationship: part_of GO:0097574 ! lateral part of cell + +[Term] +id: GO:1990795 +name: rod bipolar cell terminal bouton +namespace: cellular_component +def: "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:19883736] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:1990796 +name: photoreceptor cell terminal bouton +namespace: cellular_component +def: "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light." [PMID:19883736] +is_a: GO:0043195 ! terminal bouton + +[Term] +id: GO:1990797 +name: obsolete cholecystokinin secretion +namespace: biological_process +def: "OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain." [PMID:2755938] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "CCK secretion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990798 +name: pancreas regeneration +namespace: biological_process +def: "The regrowth of a destroyed pancreas." [PMID:1985964] +is_a: GO:0031100 ! animal organ regeneration + +[Term] +id: GO:1990799 +name: mitochondrial tRNA wobble position uridine thiolation +namespace: biological_process +def: "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579] +is_a: GO:0002143 ! tRNA wobble position uridine thiolation +is_a: GO:0070899 ! mitochondrial tRNA wobble uridine modification +is_a: GO:0070903 ! mitochondrial tRNA thio-modification + +[Term] +id: GO:1990800 +name: obsolete meiotic APC-fizzy-related complex +namespace: cellular_component +def: "OBSOLETE. An anaphase promoting complex bound to a fizzy-related family APC activator that regulates meiotic exit by activating the APC/C to target meiotic cyclins for destruction during meiosis." [PMID:11493649] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990801 +name: obsolete protein phosphorylation involved in mitotic spindle assembly +namespace: biological_process +def: "OBSOLETE. Any protein phosphorylation that is involved in mitotic spindle assembly." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21558801] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "protein amino acid phosphorylation involved in mitotic spindle assembly" EXACT [] +synonym: "protein amino acid phosphorylation involved in spindle assembly involved in mitosis" EXACT [] +synonym: "protein phosphorylation involved in spindle assembly involved in mitosis" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990802 +name: obsolete protein phosphorylation involved in DNA double-strand break processing +namespace: biological_process +def: "OBSOLETE. Any protein phosphorylation that is required for DNA double-strand break processing." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21841787] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "protein amino acid phosphorylation involved in DNA double-strand break processing" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990803 +name: obsolete protein phosphorylation involved in protein localization to spindle microtubule +namespace: biological_process +def: "OBSOLETE. Any protein phosphorylation process involved in localizing a protein to the spindle microtubule." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22521784] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "protein amino acid phosphorylation involved in protein localisation in spindle microtubule" EXACT [] +synonym: "protein amino acid phosphorylation involved in protein localisation to spindle microtubule" EXACT [] +synonym: "protein amino acid phosphorylation involved in protein localization in spindle microtubule" EXACT [] +synonym: "protein amino acid phosphorylation involved in protein localization to spindle microtubule" EXACT [] +synonym: "protein phosphorylation involved in protein localisation in spindle microtubule" EXACT [] +synonym: "protein phosphorylation involved in protein localisation to spindle microtubule" EXACT [] +synonym: "protein phosphorylation involved in protein localization in spindle microtubule" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990804 +name: obsolete protein phosphorylation involved in double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "OBSOLETE. Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22563681] +comment: This term has been obsoleted because it represents a GO-CAM model. +synonym: "protein amino acid phosphorylation involved in double-strand break repair via nonhomologous end joining" EXACT [] +synonym: "protein amino acid phosphorylation involved in NHEJ" EXACT [] +synonym: "protein phosphorylation involved in NHEJ" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990805 +name: central cylinder +namespace: cellular_component +def: "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules." [GOC:kmv, PMID:2428682, PMID:26124290] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0035869 ! ciliary transition zone + +[Term] +id: GO:1990806 +name: ligand-gated ion channel signaling pathway +namespace: biological_process +def: "A series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137] +synonym: "ligand-gated ion channel signalling pathway" EXACT [] +is_a: GO:0007165 ! signal transduction + +[Term] +id: GO:1990807 +name: obsolete protein N-acetyltransferase activity +namespace: molecular_function +def: "OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein." [GOC:dph] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990808 +name: F-bar domain binding +namespace: molecular_function +def: "Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins." [PMID:20603077] +is_a: GO:0019904 ! protein domain specific binding + +[Term] +id: GO:1990809 +name: endoplasmic reticulum tubular network membrane organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336] +is_a: GO:0071786 ! endoplasmic reticulum tubular network organization +is_a: GO:0090158 ! endoplasmic reticulum membrane organization + +[Term] +id: GO:1990810 +name: microtubule anchoring at mitotic spindle pole body +namespace: biological_process +def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:17486116] +is_a: GO:0034631 ! microtubule anchoring at spindle pole body +is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis +relationship: part_of GO:0090307 ! mitotic spindle assembly + +[Term] +id: GO:1990811 +name: MWP complex +namespace: cellular_component +def: "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607, PMID:29021344] +synonym: "Msd1-Wdr8-Pkl1 complex" EXACT [GOC:vw] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990812 +name: growth cone filopodium +namespace: cellular_component +def: "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone." [PMID:25598228] +is_a: GO:0030175 ! filopodium +is_a: GO:0043005 ! neuron projection +relationship: part_of GO:0030426 ! growth cone + +[Term] +id: GO:1990813 +name: meiotic centromeric cohesion protection +namespace: biological_process +def: "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions." [PMID:14730319, PMID:25533956] +synonym: "protection of centromeric cohesion during meiotic anaphase I" EXACT [] +is_a: GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric +relationship: part_of GO:0051455 ! monopolar spindle attachment to meiosis I kinetochore + +[Term] +id: GO:1990814 +name: DNA/DNA annealing activity +namespace: molecular_function +def: "An activity that faciliates the formation of a complementary double-stranded DNA molecule." [PMID:22888405, PMID:25520186] +synonym: "DNA reannealing activity" EXACT [] +is_a: GO:0003697 ! single-stranded DNA binding +is_a: GO:0140666 ! annealing activity + +[Term] +id: GO:1990815 +name: obsolete regulation of protein localization to cell division site after cytokinesis +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990816 +name: vacuole-mitochondrion membrane contact site +namespace: cellular_component +def: "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles." [PMID:25026035, PMID:25026036] +synonym: "vacuole and mitochondria patch" EXACT [] +synonym: "vCLAMP" EXACT [] +is_a: GO:0044232 ! organelle membrane contact site + +[Term] +id: GO:1990817 +name: RNA adenylyltransferase activity +namespace: molecular_function +def: "Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group." [GOC:vw] +is_a: GO:0004652 ! polynucleotide adenylyltransferase activity + +[Term] +id: GO:1990818 +name: L-arginine transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598] +is_a: GO:0015807 ! L-amino acid transport +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:0098655 ! cation transmembrane transport +is_a: GO:0098656 ! anion transmembrane transport +is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport + +[Term] +id: GO:1990819 +name: actin fusion focus +namespace: cellular_component +def: "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0015629 ! actin cytoskeleton +relationship: part_of GO:0043332 ! mating projection tip + +[Term] +id: GO:1990820 +name: response to mitotic DNA integrity checkpoint signaling +namespace: biological_process +def: "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling." [PMID:7548844] +synonym: "response to signal involved in mitotic DNA integrity checkpoint" EXACT [] +is_a: GO:0072402 ! response to DNA integrity checkpoint signaling +is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling + +[Term] +id: GO:1990822 +name: basic amino acid transmembrane transport +namespace: biological_process +def: "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0015802 ! basic amino acid transport + +[Term] +id: GO:1990823 +name: response to leukemia inhibitory factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913] +synonym: "response to CDF" EXACT [] +synonym: "response to cholinergic differentiation factor" EXACT [] +synonym: "response to LIF" EXACT [] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:1990824 +name: obsolete magnesium-dependent protein complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex." [PMID:10220587] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990825 +name: sequence-specific mRNA binding +namespace: molecular_function +def: "Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857] +is_a: GO:0003729 ! mRNA binding + +[Term] +id: GO:1990826 +name: nucleoplasmic periphery of the nuclear pore complex +namespace: cellular_component +def: "Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex." [PMID:10633080] +synonym: "associated with the nuclear pore" RELATED [GOC:mah] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005654 ! nucleoplasm + +[Term] +id: GO:1990827 +name: deaminase binding +namespace: molecular_function +def: "Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)." [PMID:9792439] +is_a: GO:0019899 ! enzyme binding + +[Term] +id: GO:1990828 +name: hepatocyte dedifferentiation +namespace: biological_process +def: "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:20102719] +is_a: GO:0043697 ! cell dedifferentiation + +[Term] +id: GO:1990829 +name: C-rich single-stranded DNA binding +namespace: molecular_function +def: "Binding to C-rich, single-stranded DNA." [PMID:8127654] +synonym: "C-rich ssDNA binding" EXACT [] +is_a: GO:0003697 ! single-stranded DNA binding + +[Term] +id: GO:1990830 +name: cellular response to leukemia inhibitory factor +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913] +synonym: "cellular response to CDF" EXACT [] +synonym: "cellular response to cholinergic differentiation factor" EXACT [] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:1990823 ! response to leukemia inhibitory factor + +[Term] +id: GO:1990831 +name: cellular response to carcinoembryonic antigen +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins." [PMID:10202129, PMID:14597422] +synonym: "cellular response to pregnancy specific glycoprotein" EXACT [] +is_a: GO:1904588 ! cellular response to glycoprotein + +[Term] +id: GO:1990832 +name: slow axonal transport +namespace: biological_process +def: "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition." [PMID:6378920] +is_a: GO:0008088 ! axo-dendritic transport + +[Term] +id: GO:1990833 +name: clathrin-uncoating ATPase activity +namespace: molecular_function +def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP." [PMID:6146630, PMID:8363588] +is_a: GO:0140657 ! ATP-dependent activity + +[Term] +id: GO:1990834 +name: response to odorant +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell." [PMID:11268007] +is_a: GO:0042221 ! response to chemical + +[Term] +id: GO:1990835 +name: obsolete insulin-like growth factor production +namespace: biological_process +def: "OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:21993393] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "IGF production" RELATED [] +is_obsolete: true + +[Term] +id: GO:1990836 +name: lysosomal matrix +namespace: cellular_component +def: "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome." [PMID:9395337] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0043202 ! lysosomal lumen + +[Term] +id: GO:1990837 +name: sequence-specific double-stranded DNA binding +namespace: molecular_function +def: "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl] +synonym: "sequence-specific dsDNA binding" EXACT [] +is_a: GO:0003690 ! double-stranded DNA binding +is_a: GO:0043565 ! sequence-specific DNA binding + +[Term] +id: GO:1990838 +name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends +namespace: molecular_function +def: "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)." [PMID:23022480] +is_a: GO:0000175 ! 3'-5'-exoribonuclease activity + +[Term] +id: GO:1990839 +name: response to endothelin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1990840 +name: response to lectin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444] +comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. +is_a: GO:0009607 ! response to biotic stimulus + +[Term] +id: GO:1990841 +name: promoter-specific chromatin binding +namespace: molecular_function +def: "Binding to a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729] +is_a: GO:0003682 ! chromatin binding + +[Term] +id: GO:1990842 +name: obsolete response to prenatal stress +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy." [PMID:22738222] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to PNS" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990843 +name: obsolete subsarcolemmal mitochondrion +namespace: cellular_component +def: "OBSOLETE. A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174] +comment: This term was obsoleted because it corresponds to mitochondria of specific cell types and this information should be captured as an extension. +synonym: "SS mitochondrion" EXACT [] +synonym: "SSM" EXACT [] +is_obsolete: true +consider: GO:0005739 + +[Term] +id: GO:1990844 +name: obsolete interfibrillar mitochondrion +namespace: cellular_component +def: "OBSOLETE. A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174] +comment: This term was obsoleted because it corresponds to mitochondria of specific cell types and this information should be captured as an extension. +synonym: "IFM" EXACT [] +synonym: "IMF mitochondrion" EXACT [] +synonym: "intermyofibrillar mitochondrion" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990845 +name: adaptive thermogenesis +namespace: biological_process +def: "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363] +is_a: GO:0008152 ! metabolic process + +[Term] +id: GO:1990846 +name: ribonucleoside-diphosphate reductase inhibitor activity +namespace: molecular_function +def: "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase." [PMID:16317005] +is_a: GO:0004857 ! enzyme inhibitor activity + +[Term] +id: GO:1990847 +name: obsolete peptide pheromone transmembrane export involved in positive regulation of conjugation with cellular fusion +namespace: biological_process +def: "OBSOLETE. The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [PMID:9236781] +comment: This term was obsoleted because it represents a BP in a BP and should be captured with a GO-CAM model +is_obsolete: true + +[Term] +id: GO:1990848 +name: obsolete Positive regulation of removal of reactive oxygen species +namespace: biological_process +def: "OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell." [PMID:24118096] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990849 +name: vacuolar localization +namespace: biological_process +def: "Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell." [PMID:26283797] +synonym: "maintenance of vacuolar localization" EXACT [] +synonym: "maintenance of vacuolar location" NARROW [] +synonym: "maintenance of vacuole localization" EXACT [] +synonym: "maintenance of vacuole location" EXACT [] +is_a: GO:0051640 ! organelle localization + +[Term] +id: GO:1990850 +name: H-gal-GP complex +namespace: cellular_component +def: "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus." [PMID:11166393] +synonym: "galactose-containing glycoprotein complex" NARROW [] +synonym: "Haemonchus galactose-containing glycoprotein complex" EXACT [] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:1905368 ! peptidase complex + +[Term] +id: GO:1990851 +name: Wnt-Frizzled-LRP5/6 complex +namespace: cellular_component +def: "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6." [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360] +comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form. +synonym: "Frizzled-LRP5/6 complex" RELATED [GOC:bf] +synonym: "Fz/Wnt/LRP6 complex" NARROW [PMID:20093360] +synonym: "Wnt receptor complex" BROAD [GOC:bf] +synonym: "WNT-FZD-LRP5 complex" NARROW [PMID:23209147] +synonym: "Wnt-FZD-LRP5/6 trimeric complex" EXACT [PMID:23209147] +synonym: "WNT-FZD-LRP6 complex" NARROW [PMID:23209147] +synonym: "Wnt-induced Frizzled-LRP5/6 complex" RELATED [GOC:bf] +synonym: "Wnt.Fz.LRP ternary complex" EXACT [PMID:20093360] +is_a: GO:0098797 ! plasma membrane protein complex + +[Term] +id: GO:1990852 +name: protein transport along microtubule to spindle pole body +namespace: biological_process +def: "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins." [PMID:25987607] +is_a: GO:0071989 ! establishment of protein localization to spindle pole body +is_a: GO:0098840 ! protein transport along microtubule + +[Term] +id: GO:1990853 +name: histone H2A SQE motif phosphorylation +namespace: biological_process +def: "The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone." [DOI:10.1038/35052000, PMID:15226425] +is_a: GO:0018105 ! peptidyl-serine phosphorylation +is_a: GO:1990164 ! histone H2A phosphorylation + +[Term] +id: GO:1990854 +name: vacuole-ER tethering +namespace: biological_process +def: "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:26283797] +synonym: "vacuole-endoplasmic reticulum attachment" EXACT [] +synonym: "vacuole-endoplasmic reticulum tethering" EXACT [] +synonym: "vacuole-ER attachment" EXACT [] +is_a: GO:0016043 ! cellular component organization +is_a: GO:0051685 ! maintenance of ER location +is_a: GO:0140056 ! organelle localization by membrane tethering +is_a: GO:1990849 ! vacuolar localization + +[Term] +id: GO:1990855 +name: obsolete myo-inositol import across plasma membrane +namespace: biological_process +def: "OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane." [PMID:9560432] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990856 +name: methionyl-initiator methionine tRNA binding +namespace: molecular_function +def: "Binding to methionine-initator methionine tRNA." [GOC:hjd, ISBN:9781555810733] +comment: An example of this is eukaryotic initiation factor 2 complex, which binds the methionyl-initiator methionine tRNA during ternary complex formation. The non-acylated tRNA is not bound. +is_a: GO:0000049 ! tRNA binding + +[Term] +id: GO:1990857 +name: obsolete APC-Fzr1/Mfr1 complex +namespace: cellular_component +def: "OBSOLETE. An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family." [PMID:11493649] +comment: This term was made obsolete because it is too fine-grained for GO. +is_obsolete: true +consider: GO:0005680 + +[Term] +id: GO:1990858 +name: cellular response to lectin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444] +comment: This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. +is_a: GO:1990840 ! response to lectin + +[Term] +id: GO:1990859 +name: cellular response to endothelin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1990839 ! response to endothelin + +[Term] +id: GO:1990860 +name: Pho85-Pho80 CDK-cyclin complex +namespace: cellular_component +def: "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin." [GOC:rb, PMID:8108735] +is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex + +[Term] +id: GO:1990861 +name: Ubp3-Bre5 deubiquitination complex +namespace: cellular_component +def: "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p." [GOC:rb, PMID:12778054, PMID:18391941] +synonym: "Ubp3-Bre5 ubiquitin protease complex" EXACT [] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990862 +name: nuclear membrane complex Bqt3-Bqt4 +namespace: cellular_component +def: "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4." [PMID:19948484] +is_a: GO:0098796 ! membrane protein complex +is_a: GO:0140513 ! nuclear protein-containing complex +relationship: part_of GO:0005639 ! integral component of nuclear inner membrane + +[Term] +id: GO:1990863 +name: acinar cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538] +synonym: "acinic cell proliferation" EXACT [] +synonym: "acinous cell proliferation" EXACT [] +is_a: GO:0050673 ! epithelial cell proliferation + +[Term] +id: GO:1990864 +name: response to growth hormone-releasing hormone +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins." [PMID:7720628] +synonym: "response to GHRF" EXACT [] +synonym: "response to GRF" EXACT [] +synonym: "response to growth hormone-releasing factor" EXACT [] +synonym: "response to sermorelin" RELATED [] +synonym: "response to somatocrinin" EXACT [] +synonym: "response to somatoliberin" EXACT [] +synonym: "response to somatorelin" EXACT [] +is_a: GO:0009725 ! response to hormone + +[Term] +id: GO:1990865 +name: obsolete response to intermittent hypoxia +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension." [PMID:24055447] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990866 +name: obsolete response to sustained hypoxia +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension." [PMID:24055447] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990867 +name: response to gastrin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814] +is_a: GO:0043434 ! response to peptide hormone + +[Term] +id: GO:1990868 +name: response to chemokine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082] +is_a: GO:0034097 ! response to cytokine + +[Term] +id: GO:1990869 +name: cellular response to chemokine +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082] +is_a: GO:0071345 ! cellular response to cytokine stimulus +is_a: GO:1990868 ! response to chemokine + +[Term] +id: GO:1990870 +name: obsolete protein fibril +namespace: cellular_component +def: "OBSOLETE. A polymer of proteins that form a fine fiber." [PMID:12764608] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990871 +name: Vma12-Vma22 assembly complex +namespace: cellular_component +def: "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p." [GOC:rb, PMID:9660861] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990872 +name: obsolete negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter." [GOC:rb, PMID:19793923] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "negative regulation of sterol import by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol import by negative regulation of transcription from Pol II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol import by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol import by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol import by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol import by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol influx by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by activation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by negative regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by stimulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by up regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by up-regulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake by upregulation of transcription from RNA polymerase II promoter" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:1990873 +name: intrinsic component of plasma membrane of cell tip +namespace: cellular_component +def: "The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip." [PMID:20624220] +is_a: GO:0031226 ! intrinsic component of plasma membrane +relationship: part_of GO:0031520 ! plasma membrane of cell tip + +[Term] +id: GO:1990874 +name: vascular associated smooth muscle cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467] +synonym: "vascular smooth muscle cell proliferation" EXACT [] +synonym: "VSMC proliferation" EXACT [] +is_a: GO:0048659 ! smooth muscle cell proliferation + +[Term] +id: GO:1990875 +name: nucleoplasmic side of nuclear pore +namespace: cellular_component +def: "The side of the nuclear pore complex (NPC) that faces the nucleoplasm." [PMID:8422679] +synonym: "nucleoplasmic side of NPC" EXACT [] +synonym: "nucleoplasmic side of nuclear pore complex" EXACT [] +synonym: "nucleoplasmic side of nucleopore" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:1990876 +name: cytoplasmic side of nuclear pore +namespace: cellular_component +def: "The side of the nuclear pore complex (NPC) that faces the cytoplasm." [PMID:8422679] +synonym: "cytoplasmic side of NPC" EXACT [] +synonym: "cytoplasmic side of nuclear pore complex" EXACT [] +synonym: "cytoplasmic side of nucleopore" EXACT [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005643 ! nuclear pore + +[Term] +id: GO:1990877 +name: FNIP-folliculin RagC/D GAP +namespace: cellular_component +def: "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2." [GOC:rn, PMID:24095279, PMID:26387955, PMID:34805795] +synonym: "BFC complex" EXACT [PMID:34805795] +synonym: "FLCN-FNIP1 complex" EXACT [] +synonym: "FLCN-FNIP2 complex" EXACT [] +synonym: "FNIP-Folliculin RagC/D GAP complex" EXACT [] +synonym: "Lst4-Lst7 complex" EXACT [] +is_a: GO:1902773 ! GTPase activator complex + +[Term] +id: GO:1990878 +name: cellular response to gastrin +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814] +is_a: GO:0071375 ! cellular response to peptide hormone stimulus +is_a: GO:1990867 ! response to gastrin + +[Term] +id: GO:1990879 +name: CST complex +namespace: cellular_component +def: "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:19854130, PMID:22965356] +synonym: "Cdc13-Stn1-Ten1 complex" NARROW [GOC:nc] +synonym: "CTC1-OBFC1-TEN1 complex" NARROW [GOC:nc] +is_a: GO:0000783 ! nuclear telomere cap complex + +[Term] +id: GO:1990880 +name: cellular detoxification of copper ion +namespace: biological_process +def: "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [PMID:10369673] +is_a: GO:0010273 ! detoxification of copper ion +is_a: GO:1990748 ! cellular detoxification +relationship: part_of GO:0071280 ! cellular response to copper ion + +[Term] +id: GO:1990881 +name: obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:26150418] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "down regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] +synonym: "down-regulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] +synonym: "downregulation of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] +synonym: "inhibition of transcription from RNA polymerase II promoter in response to DNA damage" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0006974 + +[Term] +id: GO:1990882 +name: rRNA acetylation +namespace: biological_process +def: "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [PMID:25402480] +is_a: GO:0000154 ! rRNA modification +is_a: GO:1990884 ! RNA acetylation + +[Term] +id: GO:1990883 +name: rRNA cytidine N-acetyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480] +is_a: GO:0008080 ! N-acetyltransferase activity + +[Term] +id: GO:1990884 +name: RNA acetylation +namespace: biological_process +def: "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule." [PMID:25402480] +is_a: GO:0009451 ! RNA modification + +[Term] +id: GO:1990885 +name: obsolete protein serine/threonine kinase binding +namespace: molecular_function +def: "OBSOLETE. Binding to a protein serine/threonine kinase." [PMID:16982699] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990887 +name: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+." [PMID:10419476] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:1990888 +name: 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity +namespace: molecular_function +def: "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+." [PMID:10419476] +is_a: GO:0008171 ! O-methyltransferase activity + +[Term] +id: GO:1990889 +name: H4K20me3 modified histone binding +namespace: molecular_function +def: "Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation." [PMID:22150589] +is_a: GO:0035064 ! methylated histone binding + +[Term] +id: GO:1990890 +name: netrin receptor binding +namespace: molecular_function +def: "Binding to a netrin receptor." [GOC:kmv, PMID:8861902, PMID:9126742] +is_a: GO:0005102 ! signaling receptor binding + +[Term] +id: GO:1990891 +name: mitotic sister chromatid arm separation +namespace: biological_process +def: "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis." [PMID:21633354] +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0051306 ! mitotic sister chromatid separation + +[Term] +id: GO:1990892 +name: mitotic chromosome arm condensation +namespace: biological_process +def: "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [PMID:21633354] +is_a: GO:0007076 ! mitotic chromosome condensation + +[Term] +id: GO:1990893 +name: mitotic chromosome centromere condensation +namespace: biological_process +def: "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis." [PMID:21633354] +synonym: "mitotic chromosome condensation at kinetochore" EXACT [] +is_a: GO:0007076 ! mitotic chromosome condensation + +[Term] +id: GO:1990894 +name: obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [PMID:22144909] +comment: This term was obsoleted during the TG review process. It should have been created using a template. +is_obsolete: true + +[Term] +id: GO:1990895 +name: regulation of protein localization to cell cortex of cell tip +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [GOC:vw, PMID:26150232] +is_a: GO:1903066 ! regulation of protein localization to cell tip +is_a: GO:1904776 ! regulation of protein localization to cell cortex +relationship: regulates GO:1990896 ! protein localization to cell cortex of cell tip + +[Term] +id: GO:1990896 +name: protein localization to cell cortex of cell tip +namespace: biological_process +def: "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip." [PMID:26150232] +is_a: GO:0072697 ! protein localization to cell cortex +is_a: GO:1990151 ! protein localization to cell tip + +[Term] +id: GO:1990897 +name: obsolete CTDK-1 complex +namespace: cellular_component +def: "OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13." [PMID:20952539, PMID:24879308] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990898 +name: meiotic DNA double-strand break clipping +namespace: biological_process +def: "The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP)." [PMID:26130711] +is_a: GO:0044260 ! cellular macromolecule metabolic process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination + +[Term] +id: GO:1990899 +name: meiotic DNA double-strand break resectioning +namespace: biological_process +def: "The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." [PMID:26130711] +is_a: GO:0044260 ! cellular macromolecule metabolic process +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0010705 ! meiotic DNA double-strand break processing involved in reciprocal meiotic recombination + +[Term] +id: GO:1990900 +name: ciliary pocket collar +namespace: cellular_component +def: "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma." [GOC:giardia, PMID:18462016, PMID:19806154] +comment: Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli. +synonym: "cilium pocket collar" EXACT [] +synonym: "flagellar collar" RELATED [] +synonym: "flagellar pocket collar" EXACT [] +synonym: "flagellar pore" RELATED [] +synonym: "flagellum pocket collar" EXACT [] +synonym: "FPC" RELATED [] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0020016 ! ciliary pocket + +[Term] +id: GO:1990901 +name: old cell pole +namespace: cellular_component +def: "The cell pole distal from the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658] +is_a: GO:0060187 ! cell pole + +[Term] +id: GO:1990902 +name: new cell pole +namespace: cellular_component +def: "The cell pole proximal to the most recent cell division." [GOC:jh2, PMID:10231492, PMID:8226658] +is_a: GO:0060187 ! cell pole + +[Term] +id: GO:1990904 +name: ribonucleoprotein complex +namespace: cellular_component +alt_id: GO:0030529 +alt_id: GO:1990903 +def: "A macromolecular complex that contains both RNA and protein molecules." [GOC:krc, GOC:vesicles] +subset: goslim_pir +synonym: "extracellular ribonucleoprotein complex" NARROW [] +synonym: "intracellular ribonucleoprotein complex" NARROW [] +synonym: "protein-RNA complex" EXACT [] +synonym: "RNA-protein complex" EXACT [] +synonym: "RNP" EXACT [] +xref: Wikipedia:Ribonucleoprotein +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990905 +name: dinoflagellate peduncle +namespace: cellular_component +def: "A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy)." [GOC:at, PMID:1480107, Wikipedia:Dinoflagellate] +comment: The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. +is_a: GO:0120025 ! plasma membrane bounded cell projection + +[Term] +id: GO:1990906 +name: accessory outer segment +namespace: cellular_component +def: "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors." [GOC:dph, PMID:25125189] +is_a: GO:0043005 ! neuron projection + +[Term] +id: GO:1990907 +name: beta-catenin-TCF complex +namespace: cellular_component +def: "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] +synonym: "beta-catenin/LEF complex" NARROW [PMID:8757136] +synonym: "beta-catenin/lymphoid enhancer binding factor complex" RELATED [PMID:8757136] +synonym: "beta-catenin/T-cell factor complex" RELATED [GOC:bf] +is_a: GO:0090575 ! RNA polymerase II transcription regulator complex + +[Term] +id: GO:1990908 +name: obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity +namespace: molecular_function +def: "OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile." [PMID:26368668] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990909 +name: Wnt signalosome +namespace: cellular_component +def: "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320] +comment: Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription. +synonym: "LRP5/6 signalosome" EXACT [GOC:bf] +synonym: "LRP6 signalosome" NARROW [PMID:22899650, PMID:25074807] +synonym: "Wnt signalosome complex" EXACT [PMID:24412065] +synonym: "Wnt-LRP5/6 signalosome" EXACT [PMID:23892894] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990910 +name: response to hypobaric hypoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level)." [PMID:24590457] +is_a: GO:0001666 ! response to hypoxia + +[Term] +id: GO:1990911 +name: response to psychosocial stress +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism." [PMID:22922217, PMID:26458179] +is_a: GO:0006950 ! response to stress + +[Term] +id: GO:1990912 +name: obsolete response to microwave radiation +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus." [PMID:21241601] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990913 +name: sperm head plasma membrane +namespace: cellular_component +def: "The plasma membrane that is part of the head section of a sperm cell." [PMID:24478030] +is_a: GO:0098590 ! plasma membrane region +relationship: part_of GO:0061827 ! sperm head +relationship: part_of GO:0097524 ! sperm plasma membrane + +[Term] +id: GO:1990914 +name: integral component of periplasmic side of plasma membrane +namespace: cellular_component +def: "The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane." [GOC:bhm, PMID:15919996] +comment: An example of this is hyaA in E. coli (P69739) in PMID:23260654 (inferred from direct assay). +is_a: GO:0031237 ! intrinsic component of periplasmic side of plasma membrane +is_a: GO:0071575 ! integral component of external side of plasma membrane + +[Term] +id: GO:1990915 +name: structural constituent of ascospore wall +namespace: molecular_function +def: "The action of a molecule that contributes to the structural integrity of an ascospore wall." [PMID:24623719] +is_a: GO:0005199 ! structural constituent of cell wall + +[Term] +id: GO:1990916 +name: Isp3 layer of spore wall +namespace: cellular_component +def: "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe." [PMID:24623719] +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005619 ! ascospore wall + +[Term] +id: GO:1990917 +name: ooplasm +namespace: cellular_component +def: "The cytoplasm of an ovum." [PMID:19022436] +is_a: GO:0005737 ! cytoplasm + +[Term] +id: GO:1990918 +name: double-strand break repair involved in meiotic recombination +namespace: biological_process +def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514] +is_a: GO:0006302 ! double-strand break repair +is_a: GO:1903046 ! meiotic cell cycle process +relationship: part_of GO:0007131 ! reciprocal meiotic recombination + +[Term] +id: GO:1990919 +name: proteasome-nuclear membrane anchor activity +namespace: molecular_function +def: "The binding activity of a molecule that brings together a proteasome complex and a nuclear inner membrane, to maintain the nuclear membrane localization of the proteasome." [PMID:16096059] +synonym: "nuclear membrane proteasome adaptor" RELATED [] +synonym: "nuclear membrane proteasome anchor" EXACT [] +synonym: "nuclear membrane proteasome tether" EXACT [] +synonym: "nuclear membrane proteasome tether activity" EXACT [] +synonym: "nuclear membrane-proteasome anchor activity" EXACT [] +synonym: "nuclear membrane-proteasome tether activity" EXACT [] +synonym: "tethering factor for nuclear proteasome" RELATED [] +is_a: GO:0043495 ! protein-membrane adaptor activity + +[Term] +id: GO:1990920 +name: proteasome localization to nuclear periphery +namespace: biological_process +def: "Any process in which the proteasome is transported to, or maintained at the nuclear periphery." [PMID:11084332] +is_a: GO:0031144 ! proteasome localization + +[Term] +id: GO:1990921 +name: obsolete proteasome localization to nuclear periphery +namespace: biological_process +def: "OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery." [PMID:16096059] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "proteasome localisation to nuclear periphery" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990922 +name: hepatic stellate cell proliferation +namespace: biological_process +def: "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260] +synonym: "hepatic perisinusoidal cell proliferation" EXACT [] +synonym: "Ito cell proliferation" EXACT [] +synonym: "perisinusoidal cell proliferation" EXACT [] +is_a: GO:0048144 ! fibroblast proliferation + +[Term] +id: GO:1990923 +name: PET complex +namespace: cellular_component +def: "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs." [PMID:26669262] +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990924 +name: obsolete amphisome membrane +namespace: cellular_component +def: "OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm." [GOC:bhm, PMID:17984323] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "amphisomal membrane" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990926 +name: short-term synaptic potentiation +namespace: biological_process +def: "The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds." [GOC:dos, GOC:sp, ISBN:9780071120005, PMID:11826273, PMID:26738595] +comment: The mechanism of short term potentiation is thought to be either increased influx of calcium into the presynapse (Zucker and Regeh, 2002 PMID:11826273) increased sensitivity to calcium (Jackman et al., 2016 PMID:26738595) or both. +synonym: "synaptic facilitation" EXACT [ISBN:9780071120005, PMID:11826273, PMID:26738595] +is_a: GO:0048167 ! regulation of synaptic plasticity + +[Term] +id: GO:1990927 +name: calcium ion regulated lysosome exocytosis +namespace: biological_process +def: "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [PMID:10725327, PMID:11511344] +is_a: GO:0017156 ! calcium-ion regulated exocytosis + +[Term] +id: GO:1990928 +name: response to amino acid starvation +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311] +is_a: GO:0042594 ! response to starvation + +[Term] +id: GO:1990929 +name: sulfoquinovosidase activity +namespace: molecular_function +def: "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose." [GOC:imk, PMID:26878550] +is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds + +[Term] +id: GO:1990930 +name: mRNA N1-methyladenosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde." [PMID:26863196, PMID:26863410] +synonym: "RNA N(1)-methyladenosine dioxygenase activity" RELATED [] +synonym: "RNA N1-methyladenosine dioxygenase activity" RELATED [] +xref: EC:1.14.11.54 +xref: RHEA:49516 +is_a: GO:0035515 ! oxidative RNA demethylase activity + +[Term] +id: GO:1990931 +name: mRNA N6-methyladenosine dioxygenase activity +namespace: molecular_function +def: "Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde." [PMID:22002720, PMID:26458103] +synonym: "mRNA N(6)-methyladenine demethylase" EXACT [] +synonym: "mRNA N(6)-methyladenosine dioxygenase activity" EXACT [] +synonym: "RNA N6-methyladenosine dioxygenase activity" RELATED [] +xref: EC:1.14.11.53 +xref: RHEA:49520 +is_a: GO:0035515 ! oxidative RNA demethylase activity + +[Term] +id: GO:1990932 +name: 5.8S rRNA binding +namespace: molecular_function +def: "Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA." [PMID:11716358, PMID:15527424] +is_a: GO:0019843 ! rRNA binding + +[Term] +id: GO:1990933 +name: microtubule cytoskeleton attachment to nuclear envelope +namespace: biological_process +def: "A process in which the microtubule cytoskeleton is attached to the nuclear envelope." [PMID:14655046, PMID:20507227] +is_a: GO:0007010 ! cytoskeleton organization + +[Term] +id: GO:1990934 +name: nucleolus-like body +namespace: cellular_component +def: "A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles." [PMID:26226217, PMID:9021878] +synonym: "compact nucleolus" EXACT [] +synonym: "NLB" EXACT [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle +relationship: part_of GO:0031981 ! nuclear lumen + +[Term] +id: GO:1990935 +name: splicing factor binding +namespace: molecular_function +def: "Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA." [PMID:11118435] +is_a: GO:0005515 ! protein binding + +[Term] +id: GO:1990936 +name: vascular associated smooth muscle cell dedifferentiation +namespace: biological_process +def: "The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:19088079] +synonym: "vascular smooth muscle cell dedifferentiation" EXACT [] +is_a: GO:0090678 ! cell dedifferentiation involved in phenotypic switching + +[Term] +id: GO:1990937 +name: xylan acetylation +namespace: biological_process +def: "The addition of one or more acetyl groups to a xylan molecule." [PMID:26745802] +is_a: GO:0043412 ! macromolecule modification +is_a: GO:0045491 ! xylan metabolic process + +[Term] +id: GO:1990938 +name: peptidyl-aspartic acid autophosphorylation +namespace: biological_process +def: "The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein." [GOC:bf, GOC:PARL, PMID:26134396] +synonym: "aspartyl autophosphorylation" EXACT [PMID:26134396] +synonym: "peptidyl-aspartate autophosphorylation" EXACT [GOC:bf] +is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation +is_a: GO:0046777 ! protein autophosphorylation + +[Term] +id: GO:1990940 +name: obsolete microtubule sliding involved in mitotic spindle elongation +namespace: biological_process +def: "OBSOLETE. The movement of one microtubule along another microtubule involved in mitotic spindle elongation." [PMID:19686686] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990941 +name: mitotic spindle kinetochore microtubule +namespace: cellular_component +def: "Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation." [PMID:18256284] +is_a: GO:0005828 ! kinetochore microtubule +is_a: GO:1990498 ! mitotic spindle microtubule + +[Term] +id: GO:1990942 +name: mitotic metaphase chromosome recapture +namespace: biological_process +alt_id: GO:1905185 +def: "A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate." [PMID:18256284] +synonym: "kinetochore retrieval" EXACT [] +synonym: "metaphase chromosome retrieval to the spindle pole body" EXACT [] +synonym: "microtubule sliding involved in kinetochore retrieval" EXACT [GOC:TermGenie] +synonym: "microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body" EXACT [GOC:TermGenie] +synonym: "microtubule sliding involved in mitotic metaphase chromosome recapture" RELATED [] +synonym: "microtubule sliding involved in sister kinetochore recapture" EXACT [GOC:TermGenie] +synonym: "sister kinetochore recapture" EXACT [] +is_a: GO:0051303 ! establishment of chromosome localization +is_a: GO:1903047 ! mitotic cell cycle process +relationship: part_of GO:0007080 ! mitotic metaphase plate congression + +[Term] +id: GO:1990943 +name: mating type region replication fork barrier binding +namespace: molecular_function +def: "Binding to the replication fork barrier found in the mating type region of fission yeast." [PMID:18723894] +synonym: "RTS1 barrier binding" EXACT [] +synonym: "RTS1 element binding" EXACT [] +is_a: GO:0031634 ! replication fork barrier binding + +[Term] +id: GO:1990946 +name: meiosis I/meiosis II transition +namespace: biological_process +def: "The cell cycle process in which a cell progresses from meiosis I to meiosis II." [PMID:21389117] +is_a: GO:0044771 ! meiotic cell cycle phase transition + +[Term] +id: GO:1990947 +name: exit from meiosis +namespace: biological_process +def: "Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half." [PMID:21389117] +synonym: "meiotic exit" EXACT [GOC:dph] +is_a: GO:0044771 ! meiotic cell cycle phase transition + +[Term] +id: GO:1990948 +name: ubiquitin ligase inhibitor activity +namespace: molecular_function +alt_id: GO:0061637 +alt_id: GO:0090645 +def: "Binds to and stops, prevents or reduces the activity of a ubiquitin ligase." [GOC:dph, GOC:vw, PMID:21389117] +synonym: "APC-Cdc20 complex inhibitor activity" NARROW [] +synonym: "mitotic anaphase-promoting complex inhibitor activity" NARROW [] +is_a: GO:0055105 ! ubiquitin-protein transferase inhibitor activity + +[Term] +id: GO:1990949 +name: metaphase/anaphase transition of meiosis I +namespace: biological_process +def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I." [ISBN:0815316194] +synonym: "first meiotic metaphase/anaphase transition" RELATED [] +synonym: "meiosis I metaphase/anaphase transition" EXACT [] +is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle +is_a: GO:0061982 ! meiosis I cell cycle process + +[Term] +id: GO:1990950 +name: metaphase/anaphase transition of meiosis II +namespace: biological_process +def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II." [ISBN:0815316194] +synonym: "meiosis II metaphase/anaphase transition" EXACT [] +synonym: "second meiotic metaphase/anaphase transition" RELATED [] +is_a: GO:0044785 ! metaphase/anaphase transition of meiotic cell cycle +is_a: GO:0061983 ! meiosis II cell cycle process + +[Term] +id: GO:1990951 +name: obsolete manchette assembly +namespace: biological_process +def: "OBSOLETE. The assembly and organization of the manchette, a tubular array of microtubules, possibly also containing actin filaments, that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990952 +name: obsolete manchette disassembly +namespace: biological_process +def: "OBSOLETE. A cellular process that results in the breakdown of a manchette." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "manchette clearance" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990953 +name: intramanchette transport +namespace: biological_process +def: "The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments." [GOC:krc, PMID:22319670, PMID:24440897, PMID:26792866] +synonym: "IMT" RELATED [] +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0098840 ! protein transport along microtubule +relationship: part_of GO:0007286 ! spermatid development + +[Term] +id: GO:1990955 +name: G-rich single-stranded DNA binding +namespace: molecular_function +def: "Binding to G-rich, single-stranded DNA." [GOC:hjd, PMID:8493094] +is_a: GO:0003697 ! single-stranded DNA binding + +[Term] +id: GO:1990956 +name: fibroblast chemotaxis +namespace: biological_process +def: "The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [GOC:dph, PMID:8760137] +is_a: GO:0060326 ! cell chemotaxis + +[Term] +id: GO:1990957 +name: NPHP complex +namespace: cellular_component +def: "A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways." [GOC:cilia, PMID:18337471, PMID:21422230, PMID:21498478, PMID:21555462, PMID:25150219] +comment: Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme. +synonym: "NPHP module" EXACT [] +is_a: GO:0032991 ! protein-containing complex +relationship: part_of GO:0035869 ! ciliary transition zone + +[Term] +id: GO:1990958 +name: obsolete response to thyrotropin-releasing hormone +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyrotropin-releasing hormone (TRH) stimulus. TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [PMID:21382270] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "response to TRH" RELATED [] +is_obsolete: true + +[Term] +id: GO:1990959 +name: eosinophil homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] +synonym: "eosinocyte homeostasis" EXACT [] +synonym: "eosinophilic granulocyte homeostasis" EXACT [] +synonym: "eosinophilic leucocyte homeostasis" EXACT [] +synonym: "eosinophilic leukocyte homeostasis" EXACT [] +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:1990960 +name: basophil homeostasis +namespace: biological_process +def: "The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [PMID:10606160] +synonym: "basophilic leucocyte homeostasis" EXACT [] +is_a: GO:0001776 ! leukocyte homeostasis +is_a: GO:0002262 ! myeloid cell homeostasis + +[Term] +id: GO:1990961 +name: xenobiotic detoxification by transmembrane export across the plasma membrane +namespace: biological_process +def: "A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell." [PMID:28355133] +synonym: "drug transmembrane export" NARROW [] +is_a: GO:0046618 ! xenobiotic export +is_a: GO:0140115 ! export across plasma membrane +relationship: part_of GO:0098754 ! detoxification + +[Term] +id: GO:1990962 +name: xenobiotic transport across blood-brain barrier +namespace: biological_process +def: "The directed movement of a xenobiotic through the blood-brain barrier." [PMID:25053619] +synonym: "drug transport across blood-brain barrier" RELATED [] +is_a: GO:0042908 ! xenobiotic transport +is_a: GO:0150104 ! transport across blood-brain barrier + +[Term] +id: GO:1990963 +name: establishment of blood-retinal barrier +namespace: biological_process +def: "Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type." [PMID:25053619] +synonym: "establishment of blood-retina barrier" EXACT [] +synonym: "establishment of BRB" RELATED [] +is_a: GO:0048468 ! cell development + +[Term] +id: GO:1990964 +name: actin cytoskeleton-regulatory complex +namespace: cellular_component +def: "A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat." [GOC:bhm, PMID:10594004, PMID:11739778] +comment: An example of this is Pan1 in Saccharomyces cerevisiae (UniProt ID P32521) in PMID:10594004 (inferred from direct assay). +is_a: GO:0032991 ! protein-containing complex + +[Term] +id: GO:1990965 +name: cytosylglucuronate decarboxylase activity +namespace: molecular_function +def: "Catalysis of the reaction: cytosylglucuronic acid + H(+) = cytosylarabinopyranose + CO(2)." [GOC:pr, GOC:tb, PMID:23874663] +comment: This enzymatic activity was shown to be involved in the bacterial blasticidin S biosynthetic pathway. +is_a: GO:0016831 ! carboxy-lyase activity + +[Term] +id: GO:1990966 +name: ATP generation from poly-ADP-D-ribose +namespace: biological_process +def: "The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming." [PMID:27257257] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0046034 ! ATP metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:1990967 +name: obsolete multi-organism toxin transport +namespace: biological_process +def: "OBSOLETE. The directed movement of a toxin into, out of or within a cell, or between cells where two or more organisms of the same or different species are involved." [GOC:bf, GOC:PARL, PMID:18191792, PMID:22042847] +comment: This term was obsoleted because there is no evidence that this process exists. +synonym: "typhoid toxin transport" NARROW [PMID:22042847] +is_obsolete: true + +[Term] +id: GO:1990968 +name: modulation by host of RNA binding by virus +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA." [GOC:bf, GOC:PARL, PMID:25116364] +comment: Note that the bound RNA may originate from the virus or another organism, including the host. +synonym: "modulation by host of viral protein:RNA interaction" RELATED [GOC:bf] +is_a: GO:0044092 ! negative regulation of molecular function +is_a: GO:0044868 ! modulation by host of viral molecular function +is_a: GO:1905214 ! regulation of RNA binding + +[Term] +id: GO:1990969 +name: modulation by host of viral RNA-binding transcription factor activity +namespace: biological_process +def: "A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor." [GOC:bf, GOC:PARL, PMID:25116364] +synonym: "modulation by host of viral Tat activity" NARROW [PMID:25116364] +is_a: GO:0043921 ! modulation by host of viral transcription +is_a: GO:0052422 ! modulation by host of symbiont catalytic activity + +[Term] +id: GO:1990970 +name: trans-activation response element binding +namespace: molecular_function +def: "Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter." [GOC:bf, GOC:PARL, PMID:25116364, Wikipedia:Trans-activation_response_element_(TAR)] +synonym: "TAR binding" EXACT [PMID:25116364] +is_a: GO:0070883 ! pre-miRNA binding + +[Term] +id: GO:1990971 +name: EMILIN complex +namespace: cellular_component +def: "Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures." [GOC:bhm, PMID:10821830] +comment: An example of this is EMILIN-1 in human (Q9Y6C2) in PMID:10821830 (inferred from direct assay). +synonym: "Elastic microfibrillar interface 1 complex" NARROW [] +synonym: "Elastic microfibrillar interface 2 complex" NARROW [] +synonym: "EMILIN-1 complex" NARROW [] +synonym: "EMILIN-2 complex" NARROW [] +is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:1990972 +name: multimerin complex +namespace: cellular_component +def: "Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures." [GOC:bhm, PMID:9454761] +comment: An example of this is Multimerin-1 in human (Q13201) in PMID:9454761. +synonym: "Elastic microfibrillar interface 3 complex" NARROW [] +synonym: "Elastic microfibrillar interface 4 complex" NARROW [] +synonym: "EMILIN-3 complex" NARROW [] +synonym: "EMILIN-4 complex" NARROW [] +synonym: "Multimerin-1 complex" NARROW [] +synonym: "Multimerin-2 complex" NARROW [] +synonym: "p155 complex" NARROW [] +synonym: "Platelet glycoprotein Ia* complex" NARROW [] +is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion +relationship: part_of GO:0062023 ! collagen-containing extracellular matrix + +[Term] +id: GO:1990973 +name: transmembrane actin-associated (TAN) line +namespace: cellular_component +def: "A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge)." [GOC:hjd, PMID:21173262] +synonym: "TAN line" RELATED [] +is_a: GO:0043232 ! intracellular non-membrane-bounded organelle + +[Term] +id: GO:1990974 +name: actin-dependent nuclear migration +namespace: biological_process +def: "The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell." [GOC:hjd, PMID:21173262] +synonym: "actin-dependent nuclear movement" RELATED [] +is_a: GO:0007097 ! nuclear migration + +[Term] +id: GO:1990976 +name: protein transport along microtubule to mitotic spindle pole body +namespace: biological_process +def: "The directed movement of a protein along a microtubule to the mitotic spindle pole body, mediated by motor proteins." [PMID:25987607] +is_a: GO:1902440 ! protein localization to mitotic spindle pole body +is_a: GO:1990852 ! protein transport along microtubule to spindle pole body + +[Term] +id: GO:1990977 +name: obsolete negative regulation of mitotic DNA replication initiation from late origin +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of firing from a late origin of replication involved in mitotic DNA replication." [PMID:26436827] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990978 +name: obsolete response to viscosity +namespace: biological_process +def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus." [PMID:7061416] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990979 +name: obsolete copper ion transport across blood-brain barrier +namespace: biological_process +def: "OBSOLETE. The directed movement of copper ions passing through the blood-brain barrier." [PMID:24614235] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "copper ion transport across BBB" RELATED [] +is_obsolete: true + +[Term] +id: GO:1990980 +name: obsolete copper ion transport across blood-CSF barrier +namespace: biological_process +def: "OBSOLETE. The directed movement of copper ions passing through the blood-cerebrospinal fluid barrier." [PMID:24614235] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +synonym: "copper ion transport across BCB" EXACT [] +synonym: "copper ion transport across blood-cerebrospinal fluid barrier" EXACT [] +is_obsolete: true + +[Term] +id: GO:1990981 +name: obsolete regulation of protein localization to cell division site involved in cell separation after cytokinesis +namespace: biological_process +def: "OBSOLETE. A regulation of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990982 +name: obsolete Immune memory response +namespace: biological_process +def: "OBSOLETE. The immune response against a previously encountered antigen being quicker and quantitatively better compared with the primary response." [PMID:26831526] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990983 +name: tRNA demethylation +namespace: biological_process +def: "The removal of a methyl group from one or more residues within a tRNA molecule." [PMID:27745969] +is_a: GO:0006400 ! tRNA modification +is_a: GO:0035513 ! oxidative RNA demethylation + +[Term] +id: GO:1990984 +name: tRNA demethylase activity +namespace: molecular_function +def: "Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule." [PMID:27745969] +is_a: GO:0035515 ! oxidative RNA demethylase activity +is_a: GO:0140101 ! catalytic activity, acting on a tRNA + +[Term] +id: GO:1990985 +name: obsolete apoptosis in response to oxidative stress +namespace: biological_process +def: "OBSOLETE. Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to oxidative stress." [GOC:pg, PMID:25950479] +comment: This term was obsoleted at the TermGenie Gatekeeper stage. +is_obsolete: true + +[Term] +id: GO:1990986 +name: DNA recombinase disassembly +namespace: biological_process +def: "The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases)." [GOC:pg, PMID:19540122] +synonym: "Rad51 nucleoprotein filament disassembly" RELATED [] +is_a: GO:0032986 ! protein-DNA complex disassembly + +[Term] +id: GO:2000001 +name: regulation of DNA damage checkpoint +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] +synonym: "regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] +is_a: GO:1901976 ! regulation of cell cycle checkpoint +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: regulates GO:0000077 ! DNA damage checkpoint signaling + +[Term] +id: GO:2000002 +name: negative regulation of DNA damage checkpoint +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol] +synonym: "negative regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] +is_a: GO:1901977 ! negative regulation of cell cycle checkpoint +is_a: GO:2000001 ! regulation of DNA damage checkpoint +is_a: GO:2001021 ! negative regulation of response to DNA damage stimulus +relationship: negatively_regulates GO:0000077 ! DNA damage checkpoint signaling + +[Term] +id: GO:2000003 +name: positive regulation of DNA damage checkpoint +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol] +synonym: "positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest" RELATED [GOC:obol] +is_a: GO:1901978 ! positive regulation of cell cycle checkpoint +is_a: GO:2000001 ! regulation of DNA damage checkpoint +is_a: GO:2001022 ! positive regulation of response to DNA damage stimulus +relationship: positively_regulates GO:0000077 ! DNA damage checkpoint signaling + +[Term] +id: GO:2000004 +name: regulation of metanephric S-shaped body morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0072284 ! metanephric S-shaped body morphogenesis + +[Term] +id: GO:2000005 +name: negative regulation of metanephric S-shaped body morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000004 ! regulation of metanephric S-shaped body morphogenesis +relationship: negatively_regulates GO:0072284 ! metanephric S-shaped body morphogenesis + +[Term] +id: GO:2000006 +name: regulation of metanephric comma-shaped body morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0072278 ! metanephric comma-shaped body morphogenesis + +[Term] +id: GO:2000007 +name: negative regulation of metanephric comma-shaped body morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000006 ! regulation of metanephric comma-shaped body morphogenesis +relationship: negatively_regulates GO:0072278 ! metanephric comma-shaped body morphogenesis + +[Term] +id: GO:2000008 +name: regulation of protein localization to cell surface +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] +synonym: "regulation of protein localisation at cell surface" EXACT [GOC:mah] +synonym: "regulation of protein localization at cell surface" EXACT [] +is_a: GO:0032880 ! regulation of protein localization +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0034394 ! protein localization to cell surface + +[Term] +id: GO:2000009 +name: negative regulation of protein localization to cell surface +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] +synonym: "negative regulation of protein localisation at cell surface" EXACT [GOC:mah] +synonym: "negative regulation of protein localization at cell surface" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:1903828 ! negative regulation of protein localization +is_a: GO:2000008 ! regulation of protein localization to cell surface +relationship: negatively_regulates GO:0034394 ! protein localization to cell surface + +[Term] +id: GO:2000010 +name: positive regulation of protein localization to cell surface +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol] +synonym: "positive regulation of protein localisation at cell surface" EXACT [GOC:mah] +synonym: "positive regulation of protein localization at cell surface" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:1903829 ! positive regulation of protein localization +is_a: GO:2000008 ! regulation of protein localization to cell surface +relationship: positively_regulates GO:0034394 ! protein localization to cell surface + +[Term] +id: GO:2000011 +name: regulation of adaxial/abaxial pattern formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol] +synonym: "regulation of adaxial/abaxial pattern specification" RELATED [GOC:obol] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0009955 ! adaxial/abaxial pattern specification + +[Term] +id: GO:2000012 +name: regulation of auxin polar transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of auxin polar transport." [GOC:obol] +is_a: GO:0010817 ! regulation of hormone levels +is_a: GO:0051049 ! regulation of transport +relationship: regulates GO:0009926 ! auxin polar transport + +[Term] +id: GO:2000013 +name: regulation of arginine biosynthetic process via ornithine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol] +synonym: "regulation of arginine anabolism via ornithine" EXACT [GOC:obol] +synonym: "regulation of arginine formation via ornithine" EXACT [GOC:obol] +synonym: "regulation of arginine synthesis via ornithine" EXACT [GOC:obol] +is_a: GO:0090368 ! regulation of ornithine metabolic process +is_a: GO:1900079 ! regulation of arginine biosynthetic process +relationship: regulates GO:0042450 ! arginine biosynthetic process via ornithine + +[Term] +id: GO:2000014 +name: regulation of endosperm development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endosperm development." [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0009960 ! endosperm development + +[Term] +id: GO:2000015 +name: regulation of determination of dorsal identity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol] +synonym: "regulation of determination of adaxial identity" RELATED [GOC:obol] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0048263 ! determination of dorsal identity + +[Term] +id: GO:2000016 +name: negative regulation of determination of dorsal identity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:BHF, GOC:obol] +synonym: "negative regulation of determination of adaxial identity" RELATED [GOC:obol] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000015 ! regulation of determination of dorsal identity +relationship: negatively_regulates GO:0048263 ! determination of dorsal identity + +[Term] +id: GO:2000017 +name: positive regulation of determination of dorsal identity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol] +synonym: "positive regulation of determination of adaxial identity" RELATED [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000015 ! regulation of determination of dorsal identity +relationship: positively_regulates GO:0048263 ! determination of dorsal identity + +[Term] +id: GO:2000018 +name: regulation of male gonad development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] +synonym: "regulation of testicular development" EXACT [GOC:obol] +synonym: "regulation of testis development" EXACT [GOC:obol] +is_a: GO:1905939 ! regulation of gonad development +relationship: regulates GO:0008584 ! male gonad development + +[Term] +id: GO:2000019 +name: negative regulation of male gonad development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf] +synonym: "negative regulation of testicular development" EXACT [GOC:obol] +synonym: "negative regulation of testis development" EXACT [GOC:obol] +is_a: GO:1905940 ! negative regulation of gonad development +is_a: GO:2000018 ! regulation of male gonad development +relationship: negatively_regulates GO:0008584 ! male gonad development + +[Term] +id: GO:2000020 +name: positive regulation of male gonad development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol] +synonym: "positive regulation of testicular development" EXACT [GOC:obol] +synonym: "positive regulation of testis development" EXACT [GOC:obol] +is_a: GO:1905941 ! positive regulation of gonad development +is_a: GO:2000018 ! regulation of male gonad development +relationship: positively_regulates GO:0008584 ! male gonad development + +[Term] +id: GO:2000022 +name: regulation of jasmonic acid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol] +synonym: "regulation of jasmonic acid mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009867 ! jasmonic acid mediated signaling pathway + +[Term] +id: GO:2000023 +name: regulation of lateral root development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lateral root development." [GOC:obol] +is_a: GO:2000069 ! regulation of post-embryonic root development +relationship: regulates GO:0048527 ! lateral root development + +[Term] +id: GO:2000024 +name: regulation of leaf development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leaf development." [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048366 ! leaf development + +[Term] +id: GO:2000025 +name: regulation of leaf formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leaf formation." [GOC:obol] +is_a: GO:1905428 ! regulation of plant organ formation +relationship: regulates GO:0010338 ! leaf formation + +[Term] +id: GO:2000026 +name: regulation of multicellular organismal development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0007275 ! multicellular organism development + +[Term] +id: GO:2000027 +name: regulation of animal organ morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of animal organ morphogenesis." [GOC:obol] +synonym: "regulation of histogenesis and organogenesis" RELATED [GOC:obol] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0009887 ! animal organ morphogenesis + +[Term] +id: GO:2000028 +name: regulation of photoperiodism, flowering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photoperiodism, flowering." [GOC:obol] +synonym: "regulation of photoperiodic control of flowering time" EXACT [GOC:obol] +synonym: "regulation of photoperiodic control of inflorescence development" EXACT [GOC:obol] +synonym: "regulation of response to day length, flowering" EXACT [GOC:obol] +synonym: "regulation of response to night length, flowering" EXACT [GOC:obol] +synonym: "regulation of response to photoperiod, flowering" EXACT [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0048573 ! photoperiodism, flowering + +[Term] +id: GO:2000029 +name: regulation of proanthocyanidin biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol] +synonym: "regulation of proanthocyanidin anabolism" EXACT [GOC:obol] +synonym: "regulation of proanthocyanidin biosynthesis" EXACT [GOC:obol] +synonym: "regulation of proanthocyanidin formation" EXACT [GOC:obol] +synonym: "regulation of proanthocyanidin synthesis" EXACT [GOC:obol] +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process +is_a: GO:2000762 ! regulation of phenylpropanoid metabolic process +relationship: regulates GO:0010023 ! proanthocyanidin biosynthetic process + +[Term] +id: GO:2000030 +name: regulation of response to red or far red light +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009639 ! response to red or far red light + +[Term] +id: GO:2000031 +name: regulation of salicylic acid mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol] +synonym: "regulation of salicylic acid mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0009863 ! salicylic acid mediated signaling pathway + +[Term] +id: GO:2000032 +name: regulation of secondary shoot formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary shoot formation." [GOC:obol] +synonym: "regulation of auxiliary shoot formation" RELATED [GOC:obol] +synonym: "regulation of axillary shoot formation" RELATED [GOC:obol] +synonym: "regulation of axillary shoot system formation" EXACT [] +synonym: "regulation of shoot branching" RELATED [] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +is_a: GO:1905428 ! regulation of plant organ formation +relationship: regulates GO:0010223 ! secondary shoot formation + +[Term] +id: GO:2000033 +name: regulation of seed dormancy process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seed dormancy process." [GOC:obol, GOC:pr, ISBN:9781405139830] +synonym: "regulation of seed dormancy" RELATED [] +is_a: GO:2000034 ! regulation of seed maturation +relationship: regulates GO:0010162 ! seed dormancy process + +[Term] +id: GO:2000034 +name: regulation of seed maturation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of seed maturation." [GOC:obol] +is_a: GO:0080050 ! regulation of seed development +relationship: regulates GO:0010431 ! seed maturation + +[Term] +id: GO:2000035 +name: regulation of stem cell division +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stem cell division." [GOC:obol] +synonym: "regulation of stem cell renewal" EXACT [GOC:obol] +is_a: GO:0051302 ! regulation of cell division +relationship: regulates GO:0017145 ! stem cell division + +[Term] +id: GO:2000036 +name: regulation of stem cell population maintenance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol] +synonym: "regulation of maintenance of pluripotency" RELATED [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0019827 ! stem cell population maintenance + +[Term] +id: GO:2000037 +name: regulation of stomatal complex patterning +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol] +is_a: GO:0051239 ! regulation of multicellular organismal process +relationship: regulates GO:0010375 ! stomatal complex patterning + +[Term] +id: GO:2000038 +name: regulation of stomatal complex development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol] +is_a: GO:0048580 ! regulation of post-embryonic development +relationship: regulates GO:0010374 ! stomatal complex development + +[Term] +id: GO:2000039 +name: regulation of trichome morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of trichome morphogenesis." [GOC:obol] +synonym: "regulation of trichome cell morphogenesis during differentiation" EXACT [GOC:obol] +is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0045595 ! regulation of cell differentiation +is_a: GO:2000024 ! regulation of leaf development +relationship: regulates GO:0010090 ! trichome morphogenesis + +[Term] +id: GO:2000040 +name: regulation of planar cell polarity pathway involved in axis elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] +is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway +relationship: regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation + +[Term] +id: GO:2000041 +name: negative regulation of planar cell polarity pathway involved in axis elongation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph] +is_a: GO:2000040 ! regulation of planar cell polarity pathway involved in axis elongation +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +relationship: negatively_regulates GO:0003402 ! planar cell polarity pathway involved in axis elongation + +[Term] +id: GO:2000042 +name: negative regulation of double-strand break repair via homologous recombination +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw] +synonym: "negative regulation of HDR" EXACT [GOC:obol] +synonym: "negative regulation of homologous recombinational repair" EXACT [GOC:obol] +synonym: "negative regulation of homology-directed repair" EXACT [GOC:obol] +synonym: "negative regulation of HRR" EXACT [GOC:obol] +synonym: "negative regulation of Rad51-dependent recombinational repair" EXACT [GOC:obol] +synonym: "negative regulation of Rhp51-dependent recombinational repair" EXACT [GOC:obol] +is_a: GO:0010569 ! regulation of double-strand break repair via homologous recombination +is_a: GO:0045910 ! negative regulation of DNA recombination +is_a: GO:2000780 ! negative regulation of double-strand break repair +relationship: negatively_regulates GO:0000724 ! double-strand break repair via homologous recombination + +[Term] +id: GO:2000043 +name: regulation of cardiac cell fate specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] +is_a: GO:0042659 ! regulation of cell fate specification +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: regulates GO:0060912 ! cardiac cell fate specification + +[Term] +id: GO:2000044 +name: negative regulation of cardiac cell fate specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF] +is_a: GO:0009996 ! negative regulation of cell fate specification +is_a: GO:1905208 ! negative regulation of cardiocyte differentiation +is_a: GO:2000043 ! regulation of cardiac cell fate specification +relationship: negatively_regulates GO:0060912 ! cardiac cell fate specification + +[Term] +id: GO:2000045 +name: regulation of G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] +comment: Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'. +is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition +is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition +relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:2000046 +name: obsolete regulation of G2 phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:vw] +comment: This term was made obsolete because we felt that phases themselves are not being regulated, it's rather the transitions between phases. If you are trying to make an annotation to x phase, it is likely that the correct process is 'regulation of x/y phase transiition. +synonym: "regulation of G2 phase of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0010389 + +[Term] +id: GO:2000047 +name: regulation of cell-cell adhesion mediated by cadherin +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] +is_a: GO:0022407 ! regulation of cell-cell adhesion +relationship: regulates GO:0044331 ! cell-cell adhesion mediated by cadherin + +[Term] +id: GO:2000048 +name: negative regulation of cell-cell adhesion mediated by cadherin +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] +is_a: GO:0022408 ! negative regulation of cell-cell adhesion +is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin +relationship: negatively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin + +[Term] +id: GO:2000049 +name: positive regulation of cell-cell adhesion mediated by cadherin +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol] +is_a: GO:0022409 ! positive regulation of cell-cell adhesion +is_a: GO:2000047 ! regulation of cell-cell adhesion mediated by cadherin +relationship: positively_regulates GO:0044331 ! cell-cell adhesion mediated by cadherin + +[Term] +id: GO:2000050 +name: regulation of non-canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] +synonym: "regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] +synonym: "regulation of non-canonical Wnt receptor signaling pathway" EXACT [] +synonym: "regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: regulates GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:2000051 +name: negative regulation of non-canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf] +synonym: "negative regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of non-canonical Wnt receptor signaling pathway" EXACT [] +synonym: "negative regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: negatively_regulates GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:2000052 +name: positive regulation of non-canonical Wnt signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf] +synonym: "positive regulation of beta-catenin-independent Wnt receptor signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of non-canonical Wnt receptor signaling pathway" EXACT [] +synonym: "positive regulation of non-canonical Wnt receptor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of non-canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: positively_regulates GO:0035567 ! non-canonical Wnt signaling pathway + +[Term] +id: GO:2000053 +name: regulation of Wnt signaling pathway involved in dorsal/ventral axis specification +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] +synonym: "regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] +synonym: "regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification + +[Term] +id: GO:2000054 +name: negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf] +synonym: "negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] +synonym: "negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification +relationship: negatively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification + +[Term] +id: GO:2000055 +name: positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol] +synonym: "positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification" EXACT [GOC:mah] +synonym: "positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification" EXACT [GOC:signaling] +is_a: GO:0030177 ! positive regulation of Wnt signaling pathway +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000053 ! regulation of Wnt signaling pathway involved in dorsal/ventral axis specification +relationship: positively_regulates GO:0044332 ! Wnt signaling pathway involved in dorsal/ventral axis specification + +[Term] +id: GO:2000056 +name: regulation of Wnt signaling pathway involved in digestive tract morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol] +synonym: "regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] +synonym: "regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" RELATED [GOC:signaling] +is_a: GO:0030111 ! regulation of Wnt signaling pathway +relationship: regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis + +[Term] +id: GO:2000057 +name: negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol] +synonym: "negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis" EXACT [] +synonym: "negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis" EXACT [GOC:mah] +synonym: "negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis" EXACT [GOC:signaling] +is_a: GO:0030178 ! negative regulation of Wnt signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000056 ! regulation of Wnt signaling pathway involved in digestive tract morphogenesis +relationship: negatively_regulates GO:0044333 ! Wnt signaling pathway involved in digestive tract morphogenesis + +[Term] +id: GO:2000058 +name: regulation of ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] +synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" RELATED [GOC:obol] +synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] +synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" RELATED [GOC:obol] +synonym: "regulation of myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" RELATED [GOC:obol] +synonym: "regulation of protein degradation tagging activity" RELATED [GOC:obol] +synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:obol] +synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitination during ubiquitin-dependent protein degradation" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" EXACT [GOC:obol] +synonym: "regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" EXACT [GOC:obol] +is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process +relationship: regulates GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:2000059 +name: negative regulation of ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] +synonym: "negative regulation of protein degradation tagging activity" BROAD [GOC:obol] +synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] +synonym: "negative regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process +is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process +relationship: negatively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:2000060 +name: positive regulation of ubiquitin-dependent protein catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent protein catabolic process." [GOC:BHF] +synonym: "positive regulation of protein degradation tagging activity" RELATED [GOC:obol] +synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process" NARROW [] +synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [GOC:obol] +synonym: "positive regulation of protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [GOC:obol] +is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process +is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process +relationship: positively_regulates GO:0006511 ! ubiquitin-dependent protein catabolic process + +[Term] +id: GO:2000061 +name: regulation of ureter smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0048634 ! regulation of muscle organ development +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: regulates GO:0072193 ! ureter smooth muscle cell differentiation + +[Term] +id: GO:2000062 +name: negative regulation of ureter smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation +relationship: negatively_regulates GO:0072193 ! ureter smooth muscle cell differentiation + +[Term] +id: GO:2000063 +name: positive regulation of ureter smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000061 ! regulation of ureter smooth muscle cell differentiation +relationship: positively_regulates GO:0072193 ! ureter smooth muscle cell differentiation + +[Term] +id: GO:2000064 +name: regulation of cortisol biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] +synonym: "regulation of cortisol anabolism" RELATED [GOC:obol] +synonym: "regulation of cortisol biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cortisol formation" EXACT [GOC:obol] +synonym: "regulation of cortisol synthesis" EXACT [GOC:obol] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process +is_a: GO:1902930 ! regulation of alcohol biosynthetic process +relationship: regulates GO:0034651 ! cortisol biosynthetic process + +[Term] +id: GO:2000065 +name: negative regulation of cortisol biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] +synonym: "negative regulation of cortisol anabolism" RELATED [GOC:obol] +synonym: "negative regulation of cortisol biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cortisol formation" EXACT [GOC:obol] +synonym: "negative regulation of cortisol synthesis" EXACT [GOC:obol] +is_a: GO:0031947 ! negative regulation of glucocorticoid biosynthetic process +is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process +is_a: GO:2000064 ! regulation of cortisol biosynthetic process +relationship: negatively_regulates GO:0034651 ! cortisol biosynthetic process + +[Term] +id: GO:2000066 +name: positive regulation of cortisol biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf] +synonym: "positive regulation of cortisol anabolism" RELATED [GOC:obol] +synonym: "positive regulation of cortisol biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cortisol formation" EXACT [GOC:obol] +synonym: "positive regulation of cortisol synthesis" EXACT [GOC:obol] +is_a: GO:0031948 ! positive regulation of glucocorticoid biosynthetic process +is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process +is_a: GO:2000064 ! regulation of cortisol biosynthetic process +relationship: positively_regulates GO:0034651 ! cortisol biosynthetic process + +[Term] +id: GO:2000067 +name: regulation of root morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of root morphogenesis." [GOC:obol] +is_a: GO:1905421 ! regulation of plant organ morphogenesis +relationship: regulates GO:0010015 ! root morphogenesis + +[Term] +id: GO:2000068 +name: regulation of defense response to insect +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol] +synonym: "regulation of physiological defense response to insect" EXACT [GOC:obol] +is_a: GO:0002831 ! regulation of response to biotic stimulus +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032101 ! regulation of response to external stimulus +relationship: regulates GO:0002213 ! defense response to insect + +[Term] +id: GO:2000069 +name: regulation of post-embryonic root development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol] +is_a: GO:0048580 ! regulation of post-embryonic development +is_a: GO:2000280 ! regulation of root development +relationship: regulates GO:0048528 ! post-embryonic root development + +[Term] +id: GO:2000070 +name: regulation of response to water deprivation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol] +synonym: "regulation of drought tolerance" RELATED [GOC:obol] +synonym: "regulation of response to dehydration" EXACT [GOC:obol] +synonym: "regulation of response to drought" EXACT [GOC:obol] +synonym: "regulation of response to thirst" EXACT [GOC:obol] +is_a: GO:0080134 ! regulation of response to stress +relationship: regulates GO:0009414 ! response to water deprivation + +[Term] +id: GO:2000071 +name: regulation of defense response by callose deposition +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol] +synonym: "regulation of callose deposition during defense response" RELATED [GOC:obol] +synonym: "regulation of callose localization during defense response" RELATED [GOC:obol] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0032879 ! regulation of localization +relationship: regulates GO:0052542 ! defense response by callose deposition + +[Term] +id: GO:2000073 +name: regulation of cytokinesis, site selection +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] +synonym: "regulation of site selection involved in cell cycle cytokinesis" EXACT [] +is_a: GO:0032954 ! regulation of cytokinetic process +relationship: regulates GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:2000074 +name: regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0003323 ! type B pancreatic cell development + +[Term] +id: GO:2000075 +name: negative regulation of cytokinesis, site selection +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] +synonym: "negative regulation of site selection involved in cell cycle cytokinesis" EXACT [] +is_a: GO:0032466 ! negative regulation of cytokinesis +is_a: GO:2000073 ! regulation of cytokinesis, site selection +relationship: negatively_regulates GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:2000076 +name: positive regulation of cytokinesis, site selection +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] +synonym: "positive regulation of site selection involved in cell cycle cytokinesis" EXACT [] +is_a: GO:0032467 ! positive regulation of cytokinesis +is_a: GO:2000073 ! regulation of cytokinesis, site selection +relationship: positively_regulates GO:0007105 ! cytokinesis, site selection + +[Term] +id: GO:2000077 +name: negative regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "negative regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "negative regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +relationship: negatively_regulates GO:0003323 ! type B pancreatic cell development + +[Term] +id: GO:2000078 +name: positive regulation of type B pancreatic cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf] +synonym: "positive regulation of pancreatic B cell development" EXACT [GOC:mah] +synonym: "positive regulation of pancreatic beta cell development" EXACT [GOC:obol] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000074 ! regulation of type B pancreatic cell development +relationship: positively_regulates GO:0003323 ! type B pancreatic cell development + +[Term] +id: GO:2000079 +name: regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] +synonym: "regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] +synonym: "regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] +is_a: GO:0060828 ! regulation of canonical Wnt signaling pathway +relationship: regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation + +[Term] +id: GO:2000080 +name: negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] +synonym: "negative regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] +synonym: "negative regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] +is_a: GO:0090090 ! negative regulation of canonical Wnt signaling pathway +is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation +relationship: negatively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation + +[Term] +id: GO:2000081 +name: positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [] +synonym: "positive regulation of canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation" EXACT [GOC:obol] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling pancreatic B cell proliferation" EXACT [GOC:mah] +synonym: "positive regulation of canonical Wnt receptor signalling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:mah] +synonym: "positive regulation of canonical Wnt-activated signaling pathway involved in controlling type B pancreatic cell proliferation" EXACT [GOC:signaling] +is_a: GO:0090263 ! positive regulation of canonical Wnt signaling pathway +is_a: GO:2000079 ! regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation +relationship: positively_regulates GO:0044343 ! canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation + +[Term] +id: GO:2000082 +name: regulation of L-ascorbic acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] +synonym: "regulation of ascorbate biosynthesis" EXACT [GOC:obol] +synonym: "regulation of ascorbate biosynthetic process" EXACT [GOC:obol] +synonym: "regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] +synonym: "regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] +synonym: "regulation of L-ascorbic acid formation" EXACT [GOC:obol] +synonym: "regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] +synonym: "regulation of vitamin C biosynthesis" EXACT [GOC:obol] +synonym: "regulation of vitamin C biosynthetic process" EXACT [GOC:obol] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0030656 ! regulation of vitamin metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process +relationship: regulates GO:0019853 ! L-ascorbic acid biosynthetic process + +[Term] +id: GO:2000083 +name: negative regulation of L-ascorbic acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407] +synonym: "negative regulation of ascorbate biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of ascorbate biosynthetic process" EXACT [GOC:obol] +synonym: "negative regulation of L-ascorbic acid anabolism" EXACT [GOC:obol] +synonym: "negative regulation of L-ascorbic acid biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of L-ascorbic acid formation" EXACT [GOC:obol] +synonym: "negative regulation of L-ascorbic acid synthesis" EXACT [GOC:obol] +synonym: "negative regulation of vitamin C biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of vitamin C biosynthetic process" EXACT [GOC:obol] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:0046137 ! negative regulation of vitamin metabolic process +is_a: GO:2000082 ! regulation of L-ascorbic acid biosynthetic process +relationship: negatively_regulates GO:0019853 ! L-ascorbic acid biosynthetic process + +[Term] +id: GO:2000084 +name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] +synonym: "regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] +is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development +relationship: regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis + +[Term] +id: GO:2000085 +name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] +synonym: "negative regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] +is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis +is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development +relationship: negatively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis + +[Term] +id: GO:2000086 +name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10] +synonym: "positive regulation of mesonephric mesenchyme to epithelial transition" RELATED [GOC:obol] +is_a: GO:2000084 ! regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis +is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development +relationship: positively_regulates GO:0061261 ! mesenchymal to epithelial transition involved in mesonephros morphogenesis + +[Term] +id: GO:2000087 +name: regulation of mesonephric glomerulus development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] +is_a: GO:0061217 ! regulation of mesonephros development +is_a: GO:0090192 ! regulation of glomerulus development +relationship: regulates GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:2000088 +name: negative regulation of mesonephric glomerulus development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] +is_a: GO:0090194 ! negative regulation of glomerulus development +is_a: GO:2000087 ! regulation of mesonephric glomerulus development +relationship: negatively_regulates GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:2000089 +name: positive regulation of mesonephric glomerulus development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10] +is_a: GO:0090193 ! positive regulation of glomerulus development +is_a: GO:2000087 ! regulation of mesonephric glomerulus development +relationship: positively_regulates GO:0061224 ! mesonephric glomerulus development + +[Term] +id: GO:2000090 +name: regulation of mesonephric glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072124 ! regulation of glomerular mesangial cell proliferation +is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development +relationship: regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development + +[Term] +id: GO:2000091 +name: negative regulation of mesonephric glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072125 ! negative regulation of glomerular mesangial cell proliferation +is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation +is_a: GO:2000607 ! negative regulation of cell proliferation involved in mesonephros development +relationship: negatively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development + +[Term] +id: GO:2000092 +name: positive regulation of mesonephric glomerular mesangial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10] +is_a: GO:0072126 ! positive regulation of glomerular mesangial cell proliferation +is_a: GO:2000090 ! regulation of mesonephric glomerular mesangial cell proliferation +is_a: GO:2000608 ! positive regulation of cell proliferation involved in mesonephros development +relationship: positively_regulates GO:0061269 ! mesonephric glomerular mesangial cell proliferation involved in mesonephros development + +[Term] +id: GO:2000093 +name: regulation of mesonephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation +relationship: regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation + +[Term] +id: GO:2000094 +name: negative regulation of mesonephric nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10] +is_a: GO:0072183 ! negative regulation of nephron tubule epithelial cell differentiation +is_a: GO:2000093 ! regulation of mesonephric nephron tubule epithelial cell differentiation +relationship: negatively_regulates GO:0061265 ! mesonephric nephron tubule epithelial cell differentiation + +[Term] +id: GO:2000095 +name: regulation of Wnt signaling pathway, planar cell polarity pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] +synonym: "regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] +synonym: "regulation of PCP pathway" EXACT [GOC:obol] +synonym: "regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] +synonym: "regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] +synonym: "regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] +synonym: "regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] +synonym: "regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] +is_a: GO:0090175 ! regulation of establishment of planar polarity +is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway +relationship: regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway + +[Term] +id: GO:2000096 +name: positive regulation of Wnt signaling pathway, planar cell polarity pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF] +synonym: "positive regulation of non-canonical Wnt signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of PCP pathway" EXACT [GOC:obol] +synonym: "positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway" EXACT [] +synonym: "positive regulation of Wnt receptor signalling pathway, planar cell polarity pathway" EXACT [GOC:obol] +synonym: "positive regulation of Wnt-activated signaling pathway, planar cell polarity pathway" EXACT [GOC:signaling] +synonym: "positive regulation of Wnt-JNK signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of Wnt-PCP signaling pathway" RELATED [GOC:obol] +is_a: GO:2000052 ! positive regulation of non-canonical Wnt signaling pathway +is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway +relationship: positively_regulates GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway + +[Term] +id: GO:2000097 +name: regulation of smooth muscle cell-matrix adhesion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] +is_a: GO:0001952 ! regulation of cell-matrix adhesion +relationship: regulates GO:0061302 ! smooth muscle cell-matrix adhesion + +[Term] +id: GO:2000098 +name: negative regulation of smooth muscle cell-matrix adhesion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF] +is_a: GO:0001953 ! negative regulation of cell-matrix adhesion +is_a: GO:2000097 ! regulation of smooth muscle cell-matrix adhesion +relationship: negatively_regulates GO:0061302 ! smooth muscle cell-matrix adhesion + +[Term] +id: GO:2000099 +name: regulation of establishment or maintenance of bipolar cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol] +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +relationship: regulates GO:0061245 ! establishment or maintenance of bipolar cell polarity + +[Term] +id: GO:2000100 +name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] +is_a: GO:2000099 ! regulation of establishment or maintenance of bipolar cell polarity +is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:2000101 +name: regulation of mammary stem cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0002174 ! mammary stem cell proliferation + +[Term] +id: GO:2000102 +name: negative regulation of mammary stem cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000101 ! regulation of mammary stem cell proliferation +relationship: negatively_regulates GO:0002174 ! mammary stem cell proliferation + +[Term] +id: GO:2000103 +name: positive regulation of mammary stem cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000101 ! regulation of mammary stem cell proliferation +relationship: positively_regulates GO:0002174 ! mammary stem cell proliferation + +[Term] +id: GO:2000104 +name: negative regulation of DNA-dependent DNA replication +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] +is_a: GO:0008156 ! negative regulation of DNA replication +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: negatively_regulates GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:2000105 +name: positive regulation of DNA-dependent DNA replication +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] +is_a: GO:0045740 ! positive regulation of DNA replication +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: positively_regulates GO:0006261 ! DNA-dependent DNA replication + +[Term] +id: GO:2000106 +name: regulation of leukocyte apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "regulation of leukocyte apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:2000107 +name: negative regulation of leukocyte apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "negative regulation of leukocyte apoptosis" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: negatively_regulates GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:2000108 +name: positive regulation of leukocyte apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "positive regulation of leukocyte apoptosis" NARROW [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: positively_regulates GO:0071887 ! leukocyte apoptotic process + +[Term] +id: GO:2000109 +name: regulation of macrophage apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "regulation of activation-induced cell death" RELATED [GOC:yaf] +synonym: "regulation of AICD" RELATED [GOC:yaf] +synonym: "regulation of macrophage apoptosis" NARROW [] +is_a: GO:0033032 ! regulation of myeloid cell apoptotic process +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: regulates GO:0071888 ! macrophage apoptotic process + +[Term] +id: GO:2000110 +name: negative regulation of macrophage apoptotic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "negative regulation of activation-induced cell death" RELATED [GOC:yaf] +synonym: "negative regulation of AICD" RELATED [GOC:yaf] +synonym: "negative regulation of macrophage apoptosis" NARROW [] +is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process +is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process +is_a: GO:2000109 ! regulation of macrophage apoptotic process +relationship: negatively_regulates GO:0071888 ! macrophage apoptotic process + +[Term] +id: GO:2000111 +name: positive regulation of macrophage apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis] +synonym: "positive regulation of activation-induced cell death" RELATED [GOC:yaf] +synonym: "positive regulation of AICD" RELATED [GOC:yaf] +synonym: "positive regulation of macrophage apoptosis" NARROW [] +is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process +is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process +is_a: GO:2000109 ! regulation of macrophage apoptotic process +relationship: positively_regulates GO:0071888 ! macrophage apoptotic process + +[Term] +id: GO:2000112 +name: regulation of cellular macromolecule biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] +synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] +synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] +synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] +synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:2000113 +name: negative regulation of cellular macromolecule biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] +synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] +synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] +synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] +synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process + +[Term] +id: GO:2000114 +name: regulation of establishment of cell polarity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph] +synonym: "regulation of bud site selection/establishment of cell polarity" RELATED [GOC:obol] +synonym: "regulation of cell polarization" EXACT [GOC:obol] +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +relationship: regulates GO:0030010 ! establishment of cell polarity + +[Term] +id: GO:2000115 +name: regulation of maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol] +is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +relationship: regulates GO:0061305 ! maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:2000116 +name: regulation of cysteine-type endopeptidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] +synonym: "regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] +synonym: "regulation of thiol endopeptidase activity" EXACT [GOC:obol] +is_a: GO:0052548 ! regulation of endopeptidase activity + +[Term] +id: GO:2000117 +name: negative regulation of cysteine-type endopeptidase activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf] +synonym: "negative regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] +synonym: "negative regulation of thiol endopeptidase activity" EXACT [GOC:obol] +is_a: GO:0010951 ! negative regulation of endopeptidase activity +is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:2000118 +name: regulation of sodium-dependent phosphate transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] +is_a: GO:0010966 ! regulation of phosphate transport +relationship: regulates GO:0044341 ! sodium-dependent phosphate transport + +[Term] +id: GO:2000119 +name: negative regulation of sodium-dependent phosphate transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport +relationship: negatively_regulates GO:0044341 ! sodium-dependent phosphate transport + +[Term] +id: GO:2000120 +name: positive regulation of sodium-dependent phosphate transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF] +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:2000118 ! regulation of sodium-dependent phosphate transport +relationship: positively_regulates GO:0044341 ! sodium-dependent phosphate transport + +[Term] +id: GO:2000121 +name: regulation of removal of superoxide radicals +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol] +synonym: "regulation of removal of O2-" EXACT [GOC:obol] +synonym: "regulation of removal of oxygen free radicals" EXACT [GOC:obol] +is_a: GO:0090322 ! regulation of superoxide metabolic process +is_a: GO:1900407 ! regulation of cellular response to oxidative stress +is_a: GO:1901031 ! regulation of response to reactive oxygen species +relationship: regulates GO:0019430 ! removal of superoxide radicals + +[Term] +id: GO:2000122 +name: negative regulation of stomatal complex development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol] +is_a: GO:0048581 ! negative regulation of post-embryonic development +is_a: GO:2000038 ! regulation of stomatal complex development +relationship: negatively_regulates GO:0010374 ! stomatal complex development + +[Term] +id: GO:2000123 +name: positive regulation of stomatal complex development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol] +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:2000038 ! regulation of stomatal complex development +relationship: positively_regulates GO:0010374 ! stomatal complex development + +[Term] +id: GO:2000124 +name: regulation of endocannabinoid signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444] +synonym: "regulation of endocannabinoid signalling pathway" EXACT [GOC:obol] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0071926 ! endocannabinoid signaling pathway + +[Term] +id: GO:2000125 +name: regulation of octopamine or tyramine signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] +synonym: "regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] +synonym: "regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0007211 ! octopamine or tyramine signaling pathway + +[Term] +id: GO:2000126 +name: negative regulation of octopamine or tyramine signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] +synonym: "negative regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] +synonym: "negative regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway +relationship: negatively_regulates GO:0007211 ! octopamine or tyramine signaling pathway + +[Term] +id: GO:2000127 +name: positive regulation of octopamine or tyramine signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah] +synonym: "positive regulation of octopamine or tyramine signalling pathway" EXACT [GOC:obol] +synonym: "positive regulation of octopamine/tyramine signaling pathway" EXACT [GOC:obol] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway +relationship: positively_regulates GO:0007211 ! octopamine or tyramine signaling pathway + +[Term] +id: GO:2000128 +name: regulation of octopamine signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] +synonym: "regulation of octopamine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway +relationship: regulates GO:0071927 ! octopamine signaling pathway + +[Term] +id: GO:2000129 +name: negative regulation of octopamine signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] +synonym: "negative regulation of octopamine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway +is_a: GO:2000128 ! regulation of octopamine signaling pathway +relationship: negatively_regulates GO:0071927 ! octopamine signaling pathway + +[Term] +id: GO:2000130 +name: positive regulation of octopamine signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah] +synonym: "positive regulation of octopamine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway +is_a: GO:2000128 ! regulation of octopamine signaling pathway +relationship: positively_regulates GO:0071927 ! octopamine signaling pathway + +[Term] +id: GO:2000131 +name: regulation of tyramine signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] +synonym: "regulation of tyramine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000125 ! regulation of octopamine or tyramine signaling pathway +relationship: regulates GO:0071928 ! tyramine signaling pathway + +[Term] +id: GO:2000132 +name: negative regulation of tyramine signaling pathway +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] +synonym: "negative regulation of tyramine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000126 ! negative regulation of octopamine or tyramine signaling pathway +is_a: GO:2000131 ! regulation of tyramine signaling pathway +relationship: negatively_regulates GO:0071928 ! tyramine signaling pathway + +[Term] +id: GO:2000133 +name: positive regulation of tyramine signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah] +synonym: "positive regulation of tyramine signalling pathway" EXACT [GOC:obol] +is_a: GO:2000127 ! positive regulation of octopamine or tyramine signaling pathway +is_a: GO:2000131 ! regulation of tyramine signaling pathway +relationship: positively_regulates GO:0071928 ! tyramine signaling pathway + +[Term] +id: GO:2000134 +name: negative regulation of G1/S transition of mitotic cell cycle +namespace: biological_process +def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] +is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition +is_a: GO:1902807 ! negative regulation of cell cycle G1/S phase transition +is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle +relationship: negatively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle + +[Term] +id: GO:2000135 +name: obsolete positive regulation of regulation of secondary heart field cardioblast proliferation +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph] +comment: This term was made obsolete because it makes no sense and was added in error. +synonym: "positive regulation of regulation of second heart field cardioblast proliferation" EXACT [GOC:obol] +synonym: "positive regulation of regulation of secondary heart field cardioblast proliferation" EXACT [] +is_obsolete: true + +[Term] +id: GO:2000136 +name: regulation of cell proliferation involved in heart morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0061323 ! cell proliferation involved in heart morphogenesis + +[Term] +id: GO:2000137 +name: negative regulation of cell proliferation involved in heart morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis +relationship: negatively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis + +[Term] +id: GO:2000138 +name: positive regulation of cell proliferation involved in heart morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis +relationship: positively_regulates GO:0061323 ! cell proliferation involved in heart morphogenesis + +[Term] +id: GO:2000139 +name: regulation of octopamine signaling pathway involved in response to food +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] +synonym: "regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] +is_a: GO:2000128 ! regulation of octopamine signaling pathway +relationship: regulates GO:0071935 ! octopamine signaling pathway involved in response to food + +[Term] +id: GO:2000140 +name: negative regulation of octopamine signaling pathway involved in response to food +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] +synonym: "negative regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] +is_a: GO:0032096 ! negative regulation of response to food +is_a: GO:2000129 ! negative regulation of octopamine signaling pathway +is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food +relationship: negatively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food + +[Term] +id: GO:2000141 +name: positive regulation of octopamine signaling pathway involved in response to food +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300] +synonym: "positive regulation of octopamine signalling pathway involved in response to food" EXACT [GOC:mah] +is_a: GO:0032097 ! positive regulation of response to food +is_a: GO:2000130 ! positive regulation of octopamine signaling pathway +is_a: GO:2000139 ! regulation of octopamine signaling pathway involved in response to food +relationship: positively_regulates GO:0071935 ! octopamine signaling pathway involved in response to food + +[Term] +id: GO:2000142 +name: regulation of DNA-templated transcription, initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] +synonym: "regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] +synonym: "regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] +is_a: GO:0006355 ! regulation of transcription, DNA-templated +relationship: regulates GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:2000143 +name: negative regulation of DNA-templated transcription, initiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] +synonym: "negative regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] +synonym: "negative regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "negative regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] +is_a: GO:0045892 ! negative regulation of transcription, DNA-templated +is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation +relationship: negatively_regulates GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:2000144 +name: positive regulation of DNA-templated transcription, initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH] +synonym: "positive regulation of DNA-dependent transcription, initiation" EXACT [GOC:txnOH] +synonym: "positive regulation of initiation of DNA-dependent transcription" EXACT [GOC:jh2] +synonym: "positive regulation of transcription initiation, DNA-dependent" EXACT [GOC:jh2] +synonym: "transactivation" RELATED [PMID:11158542] +synonym: "transcriptional transactivation" RELATED [PMID:11580863] +is_a: GO:0045893 ! positive regulation of transcription, DNA-templated +is_a: GO:2000142 ! regulation of DNA-templated transcription, initiation +relationship: positively_regulates GO:0006352 ! DNA-templated transcription, initiation + +[Term] +id: GO:2000145 +name: regulation of cell motility +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell motility." [GOC:mah] +synonym: "regulation of cell locomotion" EXACT [GOC:obol] +synonym: "regulation of cell movement" RELATED [GOC:obol] +synonym: "regulation of movement of a cell" EXACT [GOC:obol] +is_a: GO:0040012 ! regulation of locomotion +is_a: GO:0051270 ! regulation of cellular component movement +relationship: regulates GO:0048870 ! cell motility + +[Term] +id: GO:2000146 +name: negative regulation of cell motility +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah] +synonym: "negative regulation of cell locomotion" EXACT [GOC:obol] +synonym: "negative regulation of cell movement" RELATED [GOC:obol] +synonym: "negative regulation of movement of a cell" EXACT [GOC:obol] +is_a: GO:0040013 ! negative regulation of locomotion +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:2000145 ! regulation of cell motility +relationship: negatively_regulates GO:0048870 ! cell motility + +[Term] +id: GO:2000147 +name: positive regulation of cell motility +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell motility." [GOC:mah] +synonym: "positive regulation of cell locomotion" EXACT [GOC:obol] +synonym: "positive regulation of cell movement" RELATED [GOC:obol] +synonym: "positive regulation of movement of a cell" EXACT [GOC:obol] +is_a: GO:0040017 ! positive regulation of locomotion +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:2000145 ! regulation of cell motility +relationship: positively_regulates GO:0048870 ! cell motility + +[Term] +id: GO:2000148 +name: regulation of planar cell polarity pathway involved in ventricular septum morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis + +[Term] +id: GO:2000149 +name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph] +is_a: GO:2000148 ! regulation of planar cell polarity pathway involved in ventricular septum morphogenesis +is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: negatively_regulates GO:0061348 ! planar cell polarity pathway involved in ventricular septum morphogenesis + +[Term] +id: GO:2000150 +name: regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis + +[Term] +id: GO:2000151 +name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph] +is_a: GO:2000150 ! regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis +is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: negatively_regulates GO:0061350 ! planar cell polarity pathway involved in cardiac muscle tissue morphogenesis + +[Term] +id: GO:2000152 +name: regulation of ubiquitin-specific protease activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol] +synonym: "regulation of deubiquitinase activity" EXACT [] +synonym: "regulation of UBP" RELATED [GOC:obol] +synonym: "regulation of UCH2" RELATED [GOC:obol] +is_a: GO:0052547 ! regulation of peptidase activity + +[Term] +id: GO:2000153 +name: obsolete regulation of flagellar cell motility +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "regulation of flagellar cell motility" EXACT [] +is_obsolete: true +consider: GO:1902019 +consider: GO:1902021 + +[Term] +id: GO:2000154 +name: obsolete negative regulation of flagellar cell motility +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah] +comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. +synonym: "negative regulation of flagellar cell motility" EXACT [] +is_obsolete: true +consider: GO:1902020 +consider: GO:1902201 + +[Term] +id: GO:2000155 +name: positive regulation of cilium-dependent cell motility +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl] +synonym: "positive regulation of ciliary cell motility" RELATED [] +is_a: GO:1902019 ! regulation of cilium-dependent cell motility +is_a: GO:2000147 ! positive regulation of cell motility +relationship: positively_regulates GO:0060285 ! cilium-dependent cell motility + +[Term] +id: GO:2000156 +name: regulation of retrograde vesicle-mediated transport, Golgi to ER +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah] +synonym: "regulation of cis-Golgi to rough endoplasmic reticulum transport" EXACT [GOC:obol] +synonym: "regulation of cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [GOC:obol] +synonym: "regulation of cis-Golgi to rough ER transport" EXACT [GOC:obol] +synonym: "regulation of cis-Golgi to rough ER vesicle-mediated transport" EXACT [GOC:obol] +synonym: "regulation of retrograde (Golgi to ER) transport" EXACT [GOC:obol] +synonym: "regulation of retrograde transport, Golgi to endoplasmic reticulum" EXACT [GOC:obol] +synonym: "regulation of retrograde transport, Golgi to ER" EXACT [GOC:obol] +synonym: "regulation of retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [GOC:obol] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0006890 ! retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum + +[Term] +id: GO:2000157 +name: negative regulation of ubiquitin-specific protease activity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] +synonym: "negative regulation of deubiquitinase activity" EXACT [] +synonym: "negative regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] +synonym: "negative regulation of UBP" RELATED [GOC:obol] +synonym: "negative regulation of UCH2" RELATED [GOC:obol] +is_a: GO:0010466 ! negative regulation of peptidase activity +is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity + +[Term] +id: GO:2000158 +name: positive regulation of ubiquitin-specific protease activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol] +synonym: "positive regulation of deubiquitinase activity" EXACT [] +synonym: "positive regulation of ubiquitin hydrolase activity" EXACT [GOC:obol] +synonym: "positive regulation of UBP" RELATED [GOC:obol] +synonym: "positive regulation of UCH2" RELATED [GOC:obol] +is_a: GO:0010952 ! positive regulation of peptidase activity +is_a: GO:2000152 ! regulation of ubiquitin-specific protease activity + +[Term] +id: GO:2000159 +name: regulation of planar cell polarity pathway involved in heart morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] +is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development +is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway +relationship: regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis + +[Term] +id: GO:2000160 +name: negative regulation of planar cell polarity pathway involved in heart morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph] +is_a: GO:0003308 ! negative regulation of Wnt signaling pathway involved in heart development +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: negatively_regulates GO:0061346 ! planar cell polarity pathway involved in heart morphogenesis + +[Term] +id: GO:2000161 +name: regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis + +[Term] +id: GO:2000162 +name: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph] +is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis +is_a: GO:2000161 ! regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis +relationship: negatively_regulates GO:0061349 ! planar cell polarity pathway involved in cardiac right atrium morphogenesis + +[Term] +id: GO:2000163 +name: regulation of planar cell polarity pathway involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis + +[Term] +id: GO:2000164 +name: negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph] +is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis +is_a: GO:2000163 ! regulation of planar cell polarity pathway involved in outflow tract morphogenesis +relationship: negatively_regulates GO:0061347 ! planar cell polarity pathway involved in outflow tract morphogenesis + +[Term] +id: GO:2000165 +name: regulation of planar cell polarity pathway involved in pericardium morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] +is_a: GO:2000159 ! regulation of planar cell polarity pathway involved in heart morphogenesis +relationship: regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis + +[Term] +id: GO:2000166 +name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph] +is_a: GO:2000160 ! negative regulation of planar cell polarity pathway involved in heart morphogenesis +is_a: GO:2000165 ! regulation of planar cell polarity pathway involved in pericardium morphogenesis +relationship: negatively_regulates GO:0061354 ! planar cell polarity pathway involved in pericardium morphogenesis + +[Term] +id: GO:2000167 +name: regulation of planar cell polarity pathway involved in neural tube closure +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] +is_a: GO:0045995 ! regulation of embryonic development +is_a: GO:0051960 ! regulation of nervous system development +is_a: GO:0090178 ! regulation of establishment of planar polarity involved in neural tube closure +is_a: GO:2000095 ! regulation of Wnt signaling pathway, planar cell polarity pathway +relationship: regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure + +[Term] +id: GO:2000168 +name: negative regulation of planar cell polarity pathway involved in neural tube closure +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph] +is_a: GO:2000051 ! negative regulation of non-canonical Wnt signaling pathway +is_a: GO:2000167 ! regulation of planar cell polarity pathway involved in neural tube closure +relationship: negatively_regulates GO:0090179 ! planar cell polarity pathway involved in neural tube closure + +[Term] +id: GO:2000169 +name: regulation of peptidyl-cysteine S-nitrosylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] +is_a: GO:0031399 ! regulation of protein modification process +relationship: regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation + +[Term] +id: GO:2000170 +name: positive regulation of peptidyl-cysteine S-nitrosylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:2000169 ! regulation of peptidyl-cysteine S-nitrosylation +relationship: positively_regulates GO:0018119 ! peptidyl-cysteine S-nitrosylation + +[Term] +id: GO:2000171 +name: negative regulation of dendrite development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol] +is_a: GO:0010977 ! negative regulation of neuron projection development +is_a: GO:0050773 ! regulation of dendrite development +is_a: GO:0051093 ! negative regulation of developmental process +relationship: negatively_regulates GO:0016358 ! dendrite development + +[Term] +id: GO:2000172 +name: regulation of branching morphogenesis of a nerve +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] +is_a: GO:0060688 ! regulation of morphogenesis of a branching structure +relationship: regulates GO:0048755 ! branching morphogenesis of a nerve + +[Term] +id: GO:2000173 +name: negative regulation of branching morphogenesis of a nerve +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000172 ! regulation of branching morphogenesis of a nerve +relationship: negatively_regulates GO:0048755 ! branching morphogenesis of a nerve + +[Term] +id: GO:2000174 +name: regulation of pro-T cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] +synonym: "regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:0045580 ! regulation of T cell differentiation +is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation +relationship: regulates GO:0002572 ! pro-T cell differentiation + +[Term] +id: GO:2000175 +name: negative regulation of pro-T cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] +synonym: "negative regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:0045581 ! negative regulation of T cell differentiation +is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation +is_a: GO:2000174 ! regulation of pro-T cell differentiation +relationship: negatively_regulates GO:0002572 ! pro-T cell differentiation + +[Term] +id: GO:2000176 +name: positive regulation of pro-T cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF] +synonym: "positive regulation of pro-T lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:0045582 ! positive regulation of T cell differentiation +is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation +is_a: GO:2000174 ! regulation of pro-T cell differentiation +relationship: positively_regulates GO:0002572 ! pro-T cell differentiation + +[Term] +id: GO:2000177 +name: regulation of neural precursor cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0061351 ! neural precursor cell proliferation + +[Term] +id: GO:2000178 +name: negative regulation of neural precursor cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: negatively_regulates GO:0061351 ! neural precursor cell proliferation + +[Term] +id: GO:2000179 +name: positive regulation of neural precursor cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:2000177 ! regulation of neural precursor cell proliferation +relationship: positively_regulates GO:0061351 ! neural precursor cell proliferation + +[Term] +id: GO:2000180 +name: negative regulation of androgen biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph, GOC:yaf] +synonym: "negative regulation of androgen anabolism" EXACT [GOC:obol] +synonym: "negative regulation of androgen biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of androgen formation" EXACT [GOC:obol] +synonym: "negative regulation of androgen synthesis" EXACT [GOC:obol] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +relationship: negatively_regulates GO:0006702 ! androgen biosynthetic process + +[Term] +id: GO:2000181 +name: negative regulation of blood vessel morphogenesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +is_a: GO:1901343 ! negative regulation of vasculature development +relationship: negatively_regulates GO:0048514 ! blood vessel morphogenesis + +[Term] +id: GO:2000182 +name: regulation of progesterone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] +synonym: "regulation of progesterone anabolism" EXACT [GOC:obol] +synonym: "regulation of progesterone biosynthesis" EXACT [GOC:obol] +synonym: "regulation of progesterone formation" EXACT [GOC:obol] +synonym: "regulation of progesterone synthesis" EXACT [GOC:obol] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0046885 ! regulation of hormone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0006701 ! progesterone biosynthetic process + +[Term] +id: GO:2000183 +name: negative regulation of progesterone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] +synonym: "negative regulation of progesterone anabolism" EXACT [GOC:obol] +synonym: "negative regulation of progesterone biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of progesterone formation" EXACT [GOC:obol] +synonym: "negative regulation of progesterone synthesis" EXACT [GOC:obol] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0032353 ! negative regulation of hormone biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:2000182 ! regulation of progesterone biosynthetic process +relationship: negatively_regulates GO:0006701 ! progesterone biosynthetic process + +[Term] +id: GO:2000184 +name: positive regulation of progesterone biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph] +synonym: "positive regulation of progesterone anabolism" EXACT [GOC:obol] +synonym: "positive regulation of progesterone biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of progesterone formation" EXACT [GOC:obol] +synonym: "positive regulation of progesterone synthesis" EXACT [GOC:obol] +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:2000182 ! regulation of progesterone biosynthetic process +relationship: positively_regulates GO:0006701 ! progesterone biosynthetic process + +[Term] +id: GO:2000185 +name: regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "regulation of phosphate membrane transport" EXACT [] +is_a: GO:0010966 ! regulation of phosphate transport +is_a: GO:1903795 ! regulation of inorganic anion transmembrane transport +relationship: regulates GO:0035435 ! phosphate ion transmembrane transport + +[Term] +id: GO:2000186 +name: negative regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "negative regulation of phosphate membrane transport" EXACT [] +is_a: GO:1903796 ! negative regulation of inorganic anion transmembrane transport +is_a: GO:2000185 ! regulation of phosphate transmembrane transport +relationship: negatively_regulates GO:0035435 ! phosphate ion transmembrane transport + +[Term] +id: GO:2000187 +name: positive regulation of phosphate transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol] +synonym: "positive regulation of phosphate membrane transport" EXACT [] +is_a: GO:1903797 ! positive regulation of inorganic anion transmembrane transport +is_a: GO:2000185 ! regulation of phosphate transmembrane transport +relationship: positively_regulates GO:0035435 ! phosphate ion transmembrane transport + +[Term] +id: GO:2000190 +name: obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF] +comment: This term was made obsolete because it makes no sense and was added in error. +synonym: "negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor" EXACT [] +is_obsolete: true +consider: GO:0000122 +consider: GO:0004879 +consider: GO:0030374 +consider: GO:0030522 + +[Term] +id: GO:2000191 +name: regulation of fatty acid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fatty acid transport." [GOC:BHF] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0032890 ! regulation of organic acid transport +relationship: regulates GO:0015908 ! fatty acid transport + +[Term] +id: GO:2000192 +name: negative regulation of fatty acid transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0032891 ! negative regulation of organic acid transport +is_a: GO:2000191 ! regulation of fatty acid transport +relationship: negatively_regulates GO:0015908 ! fatty acid transport + +[Term] +id: GO:2000193 +name: positive regulation of fatty acid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0032892 ! positive regulation of organic acid transport +is_a: GO:2000191 ! regulation of fatty acid transport +relationship: positively_regulates GO:0015908 ! fatty acid transport + +[Term] +id: GO:2000194 +name: regulation of female gonad development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of female gonad development." [GOC:obol] +synonym: "regulation of ovarian development" EXACT [GOC:obol] +synonym: "regulation of ovary development" EXACT [GOC:obol] +is_a: GO:1905939 ! regulation of gonad development +is_a: GO:2000026 ! regulation of multicellular organismal development +relationship: regulates GO:0008585 ! female gonad development + +[Term] +id: GO:2000195 +name: negative regulation of female gonad development +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol] +synonym: "negative regulation of ovarian development" EXACT [GOC:obol] +synonym: "negative regulation of ovary development" EXACT [GOC:obol] +is_a: GO:1905940 ! negative regulation of gonad development +is_a: GO:2000194 ! regulation of female gonad development +relationship: negatively_regulates GO:0008585 ! female gonad development + +[Term] +id: GO:2000196 +name: positive regulation of female gonad development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol] +synonym: "positive regulation of ovarian development" EXACT [GOC:obol] +synonym: "positive regulation of ovary development" EXACT [GOC:obol] +is_a: GO:1905941 ! positive regulation of gonad development +is_a: GO:2000194 ! regulation of female gonad development +relationship: positively_regulates GO:0008585 ! female gonad development + +[Term] +id: GO:2000197 +name: regulation of ribonucleoprotein complex localization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] +synonym: "regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] +synonym: "regulation of RNP localization" EXACT [GOC:obol] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0071166 ! ribonucleoprotein complex localization + +[Term] +id: GO:2000198 +name: negative regulation of ribonucleoprotein complex localization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] +synonym: "negative regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "negative regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "negative regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] +synonym: "negative regulation of RNP localization" EXACT [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization +relationship: negatively_regulates GO:0071166 ! ribonucleoprotein complex localization + +[Term] +id: GO:2000199 +name: positive regulation of ribonucleoprotein complex localization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah] +synonym: "positive regulation of cellular ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "positive regulation of establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:obol] +synonym: "positive regulation of ribonucleoprotein complex localisation" EXACT [GOC:mah] +synonym: "positive regulation of RNP localization" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization +relationship: positively_regulates GO:0071166 ! ribonucleoprotein complex localization + +[Term] +id: GO:2000200 +name: regulation of ribosomal subunit export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] +synonym: "regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] +synonym: "regulation of ribosome export from nucleus" RELATED [GOC:obol] +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization +relationship: regulates GO:0000054 ! ribosomal subunit export from nucleus + +[Term] +id: GO:2000201 +name: negative regulation of ribosomal subunit export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] +synonym: "negative regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] +synonym: "negative regulation of ribosome export from nucleus" RELATED [GOC:obol] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0090071 ! negative regulation of ribosome biogenesis +is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization +is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus +relationship: negatively_regulates GO:0000054 ! ribosomal subunit export from nucleus + +[Term] +id: GO:2000202 +name: positive regulation of ribosomal subunit export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah] +synonym: "positive regulation of ribosomal subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal subunit export out of nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal subunit-nucleus export" EXACT [GOC:obol] +synonym: "positive regulation of ribosome export from nucleus" RELATED [GOC:obol] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization +is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus +relationship: positively_regulates GO:0000054 ! ribosomal subunit export from nucleus + +[Term] +id: GO:2000203 +name: regulation of ribosomal large subunit export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] +synonym: "regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus +relationship: regulates GO:0000055 ! ribosomal large subunit export from nucleus + +[Term] +id: GO:2000204 +name: negative regulation of ribosomal large subunit export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] +synonym: "negative regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "negative regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "negative regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus +is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus +relationship: negatively_regulates GO:0000055 ! ribosomal large subunit export from nucleus + +[Term] +id: GO:2000205 +name: positive regulation of ribosomal large subunit export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah] +synonym: "positive regulation of 50S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "positive regulation of 60S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "positive regulation of ribosomal large subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal large subunit export out of nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal large subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal large subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus +is_a: GO:2000203 ! regulation of ribosomal large subunit export from nucleus +relationship: positively_regulates GO:0000055 ! ribosomal large subunit export from nucleus + +[Term] +id: GO:2000206 +name: regulation of ribosomal small subunit export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] +synonym: "regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] +synonym: "regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000200 ! regulation of ribosomal subunit export from nucleus +relationship: regulates GO:0000056 ! ribosomal small subunit export from nucleus + +[Term] +id: GO:2000207 +name: negative regulation of ribosomal small subunit export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] +synonym: "negative regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "negative regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "negative regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "negative regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000201 ! negative regulation of ribosomal subunit export from nucleus +is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus +relationship: negatively_regulates GO:0000056 ! ribosomal small subunit export from nucleus + +[Term] +id: GO:2000208 +name: positive regulation of ribosomal small subunit export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah] +synonym: "positive regulation of 30S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "positive regulation of 40S ribosomal subunit export from nucleus" RELATED [GOC:obol] +synonym: "positive regulation of ribosomal small subunit export from cell nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal small subunit export out of nucleus" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal small subunit transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "positive regulation of ribosomal small subunit-nucleus export" EXACT [GOC:obol] +is_a: GO:2000202 ! positive regulation of ribosomal subunit export from nucleus +is_a: GO:2000206 ! regulation of ribosomal small subunit export from nucleus +relationship: positively_regulates GO:0000056 ! ribosomal small subunit export from nucleus + +[Term] +id: GO:2000209 +name: regulation of anoikis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anoikis." [GOC:mah] +synonym: "regulation of detachment induced cell death" EXACT [GOC:obol] +synonym: "regulation of suspension induced apoptosis" EXACT [GOC:obol] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0043276 ! anoikis + +[Term] +id: GO:2000210 +name: positive regulation of anoikis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anoikis." [GOC:mah] +synonym: "positive regulation of detachment induced cell death" EXACT [GOC:obol] +synonym: "positive regulation of suspension induced apoptosis" EXACT [GOC:obol] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:2000209 ! regulation of anoikis +relationship: positively_regulates GO:0043276 ! anoikis + +[Term] +id: GO:2000211 +name: regulation of glutamate metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamate metabolic process." [GOC:sl] +synonym: "regulation of glutamate metabolism" EXACT [GOC:obol] +synonym: "regulation of glutamic acid metabolic process" EXACT [GOC:obol] +synonym: "regulation of glutamic acid metabolism" EXACT [GOC:obol] +is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process +relationship: regulates GO:0006536 ! glutamate metabolic process + +[Term] +id: GO:2000212 +name: negative regulation of glutamate metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl] +synonym: "negative regulation of glutamate metabolism" EXACT [GOC:obol] +synonym: "negative regulation of glutamic acid metabolic process" EXACT [GOC:obol] +synonym: "negative regulation of glutamic acid metabolism" EXACT [GOC:obol] +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:2000211 ! regulation of glutamate metabolic process +relationship: negatively_regulates GO:0006536 ! glutamate metabolic process + +[Term] +id: GO:2000213 +name: positive regulation of glutamate metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl] +synonym: "positive regulation of glutamate metabolism" EXACT [GOC:obol] +synonym: "positive regulation of glutamic acid metabolic process" EXACT [GOC:obol] +synonym: "positive regulation of glutamic acid metabolism" EXACT [GOC:obol] +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:2000211 ! regulation of glutamate metabolic process +relationship: positively_regulates GO:0006536 ! glutamate metabolic process + +[Term] +id: GO:2000214 +name: regulation of proline metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proline metabolic process." [GOC:sl] +synonym: "regulation of proline metabolism" EXACT [GOC:obol] +is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process +relationship: regulates GO:0006560 ! proline metabolic process + +[Term] +id: GO:2000215 +name: negative regulation of proline metabolic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl] +synonym: "negative regulation of proline metabolism" EXACT [GOC:obol] +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:2000214 ! regulation of proline metabolic process +relationship: negatively_regulates GO:0006560 ! proline metabolic process + +[Term] +id: GO:2000216 +name: positive regulation of proline metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl] +synonym: "positive regulation of proline metabolism" EXACT [GOC:obol] +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:2000214 ! regulation of proline metabolic process +relationship: positively_regulates GO:0006560 ! proline metabolic process + +[Term] +id: GO:2000217 +name: regulation of invasive growth in response to glucose limitation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] +synonym: "regulation of colony morphology" RELATED [GOC:obol] +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells +relationship: regulates GO:0001403 ! invasive growth in response to glucose limitation + +[Term] +id: GO:2000218 +name: negative regulation of invasive growth in response to glucose limitation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] +synonym: "negative regulation of colony morphology" RELATED [GOC:obol] +is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation +relationship: negatively_regulates GO:0001403 ! invasive growth in response to glucose limitation + +[Term] +id: GO:2000219 +name: positive regulation of invasive growth in response to glucose limitation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah] +synonym: "positive regulation of colony morphology" RELATED [GOC:obol] +is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:2000217 ! regulation of invasive growth in response to glucose limitation +relationship: positively_regulates GO:0001403 ! invasive growth in response to glucose limitation + +[Term] +id: GO:2000220 +name: regulation of pseudohyphal growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pseudohyphal growth." [GOC:mah] +is_a: GO:0001558 ! regulation of cell growth +is_a: GO:0070784 ! regulation of growth of unicellular organism as a thread of attached cells +relationship: regulates GO:0007124 ! pseudohyphal growth + +[Term] +id: GO:2000221 +name: negative regulation of pseudohyphal growth +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah] +is_a: GO:0030308 ! negative regulation of cell growth +is_a: GO:0070785 ! negative regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:2000220 ! regulation of pseudohyphal growth +relationship: negatively_regulates GO:0007124 ! pseudohyphal growth + +[Term] +id: GO:2000222 +name: positive regulation of pseudohyphal growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah] +is_a: GO:0030307 ! positive regulation of cell growth +is_a: GO:0070786 ! positive regulation of growth of unicellular organism as a thread of attached cells +is_a: GO:2000220 ! regulation of pseudohyphal growth +relationship: positively_regulates GO:0007124 ! pseudohyphal growth + +[Term] +id: GO:2000223 +name: regulation of BMP signaling pathway involved in heart jogging +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF] +synonym: "regulation of BMP signalling pathway involved in heart jogging pathway involved in somitogenesis" EXACT [GOC:mah] +is_a: GO:0030510 ! regulation of BMP signaling pathway +relationship: regulates GO:0003303 ! BMP signaling pathway involved in heart jogging + +[Term] +id: GO:2000224 +name: regulation of testosterone biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] +is_a: GO:0010566 ! regulation of ketone biosynthetic process +is_a: GO:0050810 ! regulation of steroid biosynthetic process +relationship: regulates GO:0061370 ! testosterone biosynthetic process + +[Term] +id: GO:2000225 +name: negative regulation of testosterone biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf] +is_a: GO:0010894 ! negative regulation of steroid biosynthetic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:2000224 ! regulation of testosterone biosynthetic process +relationship: negatively_regulates GO:0061370 ! testosterone biosynthetic process + +[Term] +id: GO:2000226 +name: regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0003310 ! pancreatic A cell differentiation + +[Term] +id: GO:2000227 +name: negative regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "negative regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +relationship: negatively_regulates GO:0003310 ! pancreatic A cell differentiation + +[Term] +id: GO:2000228 +name: positive regulation of pancreatic A cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah] +synonym: "positive regulation of pancreatic alpha cell differentiation" EXACT [GOC:obol] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000226 ! regulation of pancreatic A cell differentiation +relationship: positively_regulates GO:0003310 ! pancreatic A cell differentiation + +[Term] +id: GO:2000229 +name: regulation of pancreatic stellate cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] +is_a: GO:0048145 ! regulation of fibroblast proliferation +relationship: regulates GO:0072343 ! pancreatic stellate cell proliferation + +[Term] +id: GO:2000230 +name: negative regulation of pancreatic stellate cell proliferation +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] +is_a: GO:0048147 ! negative regulation of fibroblast proliferation +is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation +relationship: negatively_regulates GO:0072343 ! pancreatic stellate cell proliferation + +[Term] +id: GO:2000231 +name: positive regulation of pancreatic stellate cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah] +is_a: GO:0048146 ! positive regulation of fibroblast proliferation +is_a: GO:2000229 ! regulation of pancreatic stellate cell proliferation +relationship: positively_regulates GO:0072343 ! pancreatic stellate cell proliferation + +[Term] +id: GO:2000232 +name: regulation of rRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of rRNA processing." [GOC:mah] +synonym: "regulation of 35S primary transcript processing" RELATED [GOC:obol] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0006364 ! rRNA processing + +[Term] +id: GO:2000233 +name: negative regulation of rRNA processing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah] +synonym: "negative regulation of 35S primary transcript processing" RELATED [GOC:obol] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:0090071 ! negative regulation of ribosome biogenesis +is_a: GO:2000232 ! regulation of rRNA processing +relationship: negatively_regulates GO:0006364 ! rRNA processing + +[Term] +id: GO:2000234 +name: positive regulation of rRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah] +synonym: "positive regulation of 35S primary transcript processing" RELATED [GOC:obol] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:2000232 ! regulation of rRNA processing +relationship: positively_regulates GO:0006364 ! rRNA processing + +[Term] +id: GO:2000235 +name: regulation of tRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tRNA processing." [GOC:mah] +synonym: "regulation of tRNA maturation" EXACT [GOC:obol] +is_a: GO:0010468 ! regulation of gene expression +is_a: GO:1903326 ! regulation of tRNA metabolic process +relationship: regulates GO:0008033 ! tRNA processing + +[Term] +id: GO:2000236 +name: negative regulation of tRNA processing +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah] +synonym: "negative regulation of tRNA maturation" EXACT [GOC:obol] +is_a: GO:0010629 ! negative regulation of gene expression +is_a: GO:1903327 ! negative regulation of tRNA metabolic process +is_a: GO:2000235 ! regulation of tRNA processing +relationship: negatively_regulates GO:0008033 ! tRNA processing + +[Term] +id: GO:2000237 +name: positive regulation of tRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah] +synonym: "positive regulation of tRNA maturation" EXACT [GOC:obol] +is_a: GO:0010628 ! positive regulation of gene expression +is_a: GO:1903328 ! positive regulation of tRNA metabolic process +is_a: GO:2000235 ! regulation of tRNA processing +relationship: positively_regulates GO:0008033 ! tRNA processing + +[Term] +id: GO:2000238 +name: regulation of tRNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] +synonym: "regulation of tRNA export from cell nucleus" EXACT [GOC:obol] +synonym: "regulation of tRNA export out of nucleus" EXACT [GOC:obol] +synonym: "regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "regulation of tRNA-nucleus export" EXACT [GOC:obol] +is_a: GO:0046831 ! regulation of RNA export from nucleus +is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization +relationship: regulates GO:0006409 ! tRNA export from nucleus + +[Term] +id: GO:2000239 +name: negative regulation of tRNA export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] +synonym: "negative regulation of tRNA export from cell nucleus" EXACT [GOC:obol] +synonym: "negative regulation of tRNA export out of nucleus" EXACT [GOC:obol] +synonym: "negative regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "negative regulation of tRNA-nucleus export" EXACT [GOC:obol] +is_a: GO:0046832 ! negative regulation of RNA export from nucleus +is_a: GO:2000198 ! negative regulation of ribonucleoprotein complex localization +is_a: GO:2000238 ! regulation of tRNA export from nucleus +relationship: negatively_regulates GO:0006409 ! tRNA export from nucleus + +[Term] +id: GO:2000240 +name: positive regulation of tRNA export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah] +synonym: "positive regulation of tRNA export from cell nucleus" EXACT [GOC:obol] +synonym: "positive regulation of tRNA export out of nucleus" EXACT [GOC:obol] +synonym: "positive regulation of tRNA transport from nucleus to cytoplasm" EXACT [GOC:obol] +synonym: "positive regulation of tRNA-nucleus export" EXACT [GOC:obol] +is_a: GO:0046833 ! positive regulation of RNA export from nucleus +is_a: GO:2000199 ! positive regulation of ribonucleoprotein complex localization +is_a: GO:2000238 ! regulation of tRNA export from nucleus +relationship: positively_regulates GO:0006409 ! tRNA export from nucleus + +[Term] +id: GO:2000241 +name: regulation of reproductive process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] +is_a: GO:0050789 ! regulation of biological process +relationship: regulates GO:0022414 ! reproductive process + +[Term] +id: GO:2000242 +name: negative regulation of reproductive process +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:2000241 ! regulation of reproductive process +relationship: negatively_regulates GO:0022414 ! reproductive process + +[Term] +id: GO:2000243 +name: positive regulation of reproductive process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah] +is_a: GO:0048518 ! positive regulation of biological process +is_a: GO:2000241 ! regulation of reproductive process +relationship: positively_regulates GO:0022414 ! reproductive process + +[Term] +id: GO:2000244 +name: regulation of FtsZ-dependent cytokinesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of FtsZ-dependent cytokinesis." [GOC:mah] +synonym: "regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] +synonym: "regulation of prokaryotic fission" RELATED [GOC:obol] +is_a: GO:0032465 ! regulation of cytokinesis +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0043093 ! FtsZ-dependent cytokinesis + +[Term] +id: GO:2000245 +name: negative regulation of FtsZ-dependent cytokinesis +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah] +synonym: "negative regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] +synonym: "negative regulation of prokaryotic fission" RELATED [GOC:obol] +is_a: GO:0032466 ! negative regulation of cytokinesis +is_a: GO:2000242 ! negative regulation of reproductive process +is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis +relationship: negatively_regulates GO:0043093 ! FtsZ-dependent cytokinesis + +[Term] +id: GO:2000246 +name: positive regulation of FtsZ-dependent cytokinesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah] +synonym: "positive regulation of prokaryote-type cytokinesis" RELATED [GOC:obol] +synonym: "positive regulation of prokaryotic fission" RELATED [GOC:obol] +is_a: GO:0032467 ! positive regulation of cytokinesis +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2000244 ! regulation of FtsZ-dependent cytokinesis +relationship: positively_regulates GO:0043093 ! FtsZ-dependent cytokinesis + +[Term] +id: GO:2000247 +name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol] +is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: positively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:2000248 +name: negative regulation of establishment or maintenance of neuroblast polarity +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol] +synonym: "negative regulation of establishment and/or maintenance of neuroblast cell polarity" EXACT [GOC:obol] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +is_a: GO:0045769 ! negative regulation of asymmetric cell division +relationship: negatively_regulates GO:0045196 ! establishment or maintenance of neuroblast polarity + +[Term] +id: GO:2000249 +name: regulation of actin cytoskeleton reorganization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] +synonym: "regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] +synonym: "regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] +is_a: GO:0032956 ! regulation of actin cytoskeleton organization +relationship: regulates GO:0031532 ! actin cytoskeleton reorganization + +[Term] +id: GO:2000250 +name: negative regulation of actin cytoskeleton reorganization +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] +synonym: "negative regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] +synonym: "negative regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization +relationship: negatively_regulates GO:0031532 ! actin cytoskeleton reorganization + +[Term] +id: GO:2000251 +name: positive regulation of actin cytoskeleton reorganization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF] +synonym: "positive regulation of actin cytoskeleton remodeling" EXACT [GOC:obol] +synonym: "positive regulation of actin cytoskeleton reorganisation" EXACT [GOC:obol] +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:2000249 ! regulation of actin cytoskeleton reorganization +relationship: positively_regulates GO:0031532 ! actin cytoskeleton reorganization + +[Term] +id: GO:2000252 +name: negative regulation of feeding behavior +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol] +synonym: "negative regulation of behavioral response to food" EXACT [GOC:obol] +synonym: "negative regulation of behavioural response to food" EXACT [GOC:obol] +synonym: "negative regulation of drinking" RELATED [GOC:obol] +synonym: "negative regulation of eating" RELATED [GOC:obol] +synonym: "negative regulation of feeding behaviour" EXACT [GOC:obol] +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:0060259 ! regulation of feeding behavior +relationship: negatively_regulates GO:0007631 ! feeding behavior + +[Term] +id: GO:2000253 +name: positive regulation of feeding behavior +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol] +synonym: "positive regulation of behavioral response to food" EXACT [GOC:obol] +synonym: "positive regulation of behavioural response to food" EXACT [GOC:obol] +synonym: "positive regulation of drinking" RELATED [GOC:obol] +synonym: "positive regulation of eating" RELATED [GOC:obol] +synonym: "positive regulation of feeding behaviour" EXACT [GOC:obol] +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:0060259 ! regulation of feeding behavior +relationship: positively_regulates GO:0007631 ! feeding behavior + +[Term] +id: GO:2000254 +name: regulation of male germ cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol] +is_a: GO:1905936 ! regulation of germ cell proliferation +relationship: regulates GO:0002176 ! male germ cell proliferation + +[Term] +id: GO:2000255 +name: negative regulation of male germ cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol] +is_a: GO:1905937 ! negative regulation of germ cell proliferation +is_a: GO:2000254 ! regulation of male germ cell proliferation +relationship: negatively_regulates GO:0002176 ! male germ cell proliferation + +[Term] +id: GO:2000256 +name: positive regulation of male germ cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol] +is_a: GO:1905938 ! positive regulation of germ cell proliferation +is_a: GO:2000254 ! regulation of male germ cell proliferation +relationship: positively_regulates GO:0002176 ! male germ cell proliferation + +[Term] +id: GO:2000257 +name: regulation of protein activation cascade +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein activation cascade." [GOC:mah] +synonym: "regulation of protein activation pathway" EXACT [GOC:obol] +synonym: "regulation of protein activitory cascade" EXACT [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0051246 ! regulation of protein metabolic process +relationship: regulates GO:0072376 ! protein activation cascade + +[Term] +id: GO:2000258 +name: negative regulation of protein activation cascade +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah] +synonym: "negative regulation of protein activation pathway" EXACT [GOC:obol] +synonym: "negative regulation of protein activitory cascade" EXACT [GOC:obol] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0051248 ! negative regulation of protein metabolic process +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: negatively_regulates GO:0072376 ! protein activation cascade + +[Term] +id: GO:2000259 +name: positive regulation of protein activation cascade +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah] +synonym: "positive regulation of protein activation pathway" EXACT [GOC:obol] +synonym: "positive regulation of protein activitory cascade" EXACT [GOC:obol] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0051247 ! positive regulation of protein metabolic process +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: positively_regulates GO:0072376 ! protein activation cascade + +[Term] +id: GO:2000260 +name: regulation of blood coagulation, common pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: regulates GO:0072377 ! blood coagulation, common pathway + +[Term] +id: GO:2000261 +name: negative regulation of blood coagulation, common pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:2000258 ! negative regulation of protein activation cascade +is_a: GO:2000260 ! regulation of blood coagulation, common pathway +relationship: negatively_regulates GO:0072377 ! blood coagulation, common pathway + +[Term] +id: GO:2000262 +name: positive regulation of blood coagulation, common pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah] +is_a: GO:0030194 ! positive regulation of blood coagulation +is_a: GO:2000259 ! positive regulation of protein activation cascade +is_a: GO:2000260 ! regulation of blood coagulation, common pathway +relationship: positively_regulates GO:0072377 ! blood coagulation, common pathway + +[Term] +id: GO:2000263 +name: regulation of blood coagulation, extrinsic pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: regulates GO:0007598 ! blood coagulation, extrinsic pathway + +[Term] +id: GO:2000264 +name: negative regulation of blood coagulation, extrinsic pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:2000258 ! negative regulation of protein activation cascade +is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway +relationship: negatively_regulates GO:0007598 ! blood coagulation, extrinsic pathway + +[Term] +id: GO:2000265 +name: positive regulation of blood coagulation, extrinsic pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah] +is_a: GO:0030194 ! positive regulation of blood coagulation +is_a: GO:2000259 ! positive regulation of protein activation cascade +is_a: GO:2000263 ! regulation of blood coagulation, extrinsic pathway +relationship: positively_regulates GO:0007598 ! blood coagulation, extrinsic pathway + +[Term] +id: GO:2000266 +name: regulation of blood coagulation, intrinsic pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] +is_a: GO:0030193 ! regulation of blood coagulation +is_a: GO:2000257 ! regulation of protein activation cascade +relationship: regulates GO:0007597 ! blood coagulation, intrinsic pathway + +[Term] +id: GO:2000267 +name: negative regulation of blood coagulation, intrinsic pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] +is_a: GO:0030195 ! negative regulation of blood coagulation +is_a: GO:2000258 ! negative regulation of protein activation cascade +is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway +relationship: negatively_regulates GO:0007597 ! blood coagulation, intrinsic pathway + +[Term] +id: GO:2000268 +name: positive regulation of blood coagulation, intrinsic pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah] +is_a: GO:0030194 ! positive regulation of blood coagulation +is_a: GO:2000259 ! positive regulation of protein activation cascade +is_a: GO:2000266 ! regulation of blood coagulation, intrinsic pathway +relationship: positively_regulates GO:0007597 ! blood coagulation, intrinsic pathway + +[Term] +id: GO:2000269 +name: regulation of fibroblast apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] +synonym: "regulation of fibroblast apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0044346 ! fibroblast apoptotic process + +[Term] +id: GO:2000270 +name: negative regulation of fibroblast apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] +synonym: "negative regulation of fibroblast apoptosis" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:2000269 ! regulation of fibroblast apoptotic process +relationship: negatively_regulates GO:0044346 ! fibroblast apoptotic process + +[Term] +id: GO:2000271 +name: positive regulation of fibroblast apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf] +synonym: "positive regulation of fibroblast apoptosis" NARROW [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:2000269 ! regulation of fibroblast apoptotic process +relationship: positively_regulates GO:0044346 ! fibroblast apoptotic process + +[Term] +id: GO:2000272 +name: negative regulation of signaling receptor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity." [GOC:obol] +synonym: "negative regulation of receptor activity" BROAD [] +synonym: "negative regulation of signalling receptor activity" EXACT [] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:0044092 ! negative regulation of molecular function + +[Term] +id: GO:2000273 +name: positive regulation of signaling receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling receptor activity." [GOC:obol] +synonym: "positive regulation of signalling receptor activity" EXACT [] +is_a: GO:0010469 ! regulation of signaling receptor activity +is_a: GO:0044093 ! positive regulation of molecular function + +[Term] +id: GO:2000274 +name: regulation of epithelial cell migration, open tracheal system +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol] +synonym: "regulation of tracheal cell migration" RELATED [GOC:obol] +synonym: "regulation of tracheal epithelial cell migration" RELATED [GOC:obol] +is_a: GO:0010632 ! regulation of epithelial cell migration +relationship: regulates GO:0007427 ! epithelial cell migration, open tracheal system + +[Term] +id: GO:2000275 +name: regulation of oxidative phosphorylation uncoupler activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] +synonym: "regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] +synonym: "regulation of uncoupling protein activity" RELATED [GOC:obol] +is_a: GO:0010155 ! regulation of proton transport +is_a: GO:0022898 ! regulation of transmembrane transporter activity + +[Term] +id: GO:2000276 +name: negative regulation of oxidative phosphorylation uncoupler activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] +synonym: "negative regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] +synonym: "negative regulation of uncoupling protein activity" RELATED [GOC:obol] +is_a: GO:0032410 ! negative regulation of transporter activity +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity + +[Term] +id: GO:2000277 +name: positive regulation of oxidative phosphorylation uncoupler activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah] +synonym: "positive regulation of mitochondrial uncoupling protein activity" RELATED [GOC:obol] +synonym: "positive regulation of uncoupling protein activity" RELATED [GOC:obol] +is_a: GO:0032411 ! positive regulation of transporter activity +is_a: GO:2000275 ! regulation of oxidative phosphorylation uncoupler activity + +[Term] +id: GO:2000278 +name: regulation of DNA biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] +synonym: "regulation of DNA anabolism" EXACT [GOC:obol] +synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] +synonym: "regulation of DNA formation" EXACT [GOC:obol] +synonym: "regulation of DNA synthesis" EXACT [GOC:obol] +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0071897 ! DNA biosynthetic process + +[Term] +id: GO:2000279 +name: negative regulation of DNA biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] +synonym: "negative regulation of DNA anabolism" EXACT [GOC:obol] +synonym: "negative regulation of DNA biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of DNA formation" EXACT [GOC:obol] +synonym: "negative regulation of DNA synthesis" EXACT [GOC:obol] +is_a: GO:0051053 ! negative regulation of DNA metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: negatively_regulates GO:0071897 ! DNA biosynthetic process + +[Term] +id: GO:2000280 +name: regulation of root development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of root development." [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0048364 ! root development + +[Term] +id: GO:2000281 +name: regulation of histone H3-T3 phosphorylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol] +is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation +is_a: GO:0033127 ! regulation of histone phosphorylation +relationship: regulates GO:0072355 ! histone H3-T3 phosphorylation + +[Term] +id: GO:2000282 +name: regulation of cellular amino acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] +synonym: "regulation of amino acid biosynthetic process" EXACT [GOC:obol] +synonym: "regulation of cellular amino acid anabolism" EXACT [GOC:obol] +synonym: "regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellular amino acid formation" EXACT [GOC:obol] +synonym: "regulation of cellular amino acid synthesis" EXACT [GOC:obol] +is_a: GO:0006521 ! regulation of cellular amino acid metabolic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +relationship: regulates GO:0008652 ! cellular amino acid biosynthetic process + +[Term] +id: GO:2000283 +name: negative regulation of cellular amino acid biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] +synonym: "negative regulation of amino acid biosynthetic process" EXACT [GOC:obol] +synonym: "negative regulation of cellular amino acid anabolism" EXACT [GOC:obol] +synonym: "negative regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellular amino acid formation" EXACT [GOC:obol] +synonym: "negative regulation of cellular amino acid synthesis" EXACT [GOC:obol] +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process +is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: negatively_regulates GO:0008652 ! cellular amino acid biosynthetic process + +[Term] +id: GO:2000284 +name: positive regulation of cellular amino acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol] +synonym: "positive regulation of amino acid biosynthetic process" EXACT [GOC:obol] +synonym: "positive regulation of cellular amino acid anabolism" EXACT [GOC:obol] +synonym: "positive regulation of cellular amino acid biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cellular amino acid formation" EXACT [GOC:obol] +synonym: "positive regulation of cellular amino acid synthesis" EXACT [GOC:obol] +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: positively_regulates GO:0008652 ! cellular amino acid biosynthetic process + +[Term] +id: GO:2000285 +name: obsolete negative regulation of regulation of excitatory postsynaptic membrane potential +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF] +comment: This term was made obsolete because it makes no sense and was added in error. +synonym: "negative regulation of EPSP" RELATED [GOC:obol] +synonym: "negative regulation of regulation of excitatory postsynaptic membrane potential" EXACT [] +is_obsolete: true +replaced_by: GO:0090394 + +[Term] +id: GO:2000286 +name: receptor internalization involved in canonical Wnt signaling pathway +namespace: biological_process +def: "A receptor internalization process that contributes to canonical Wnt signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161] +synonym: "receptor internalization involved in canonical Wnt receptor signaling pathway" EXACT [] +synonym: "receptor internalization involved in canonical Wnt receptor signalling pathway" EXACT [GOC:obol] +synonym: "receptor internalization involved in canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] +synonym: "receptor internalization involved in frizzled-1 receptor signaling pathway" RELATED [GOC:obol] +synonym: "receptor internalization involved in Wnt receptor signaling pathway through beta-catenin" EXACT [GOC:obol] +synonym: "receptor internalization involved in Wnt receptor signaling pathway via beta-catenin" EXACT [GOC:obol] +synonym: "receptor internalization involved in Wnt receptor signalling pathway through beta-catenin" EXACT [GOC:obol] +is_a: GO:0031623 ! receptor internalization +relationship: part_of GO:0060070 ! canonical Wnt signaling pathway + +[Term] +id: GO:2000287 +name: positive regulation of myotome development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000290 ! regulation of myotome development +relationship: positively_regulates GO:0061055 ! myotome development + +[Term] +id: GO:2000288 +name: positive regulation of myoblast proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:2000291 ! regulation of myoblast proliferation +relationship: positively_regulates GO:0051450 ! myoblast proliferation + +[Term] +id: GO:2000289 +name: regulation of photoreceptor cell axon guidance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah] +synonym: "regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] +is_a: GO:1902667 ! regulation of axon guidance +relationship: regulates GO:0072499 ! photoreceptor cell axon guidance + +[Term] +id: GO:2000290 +name: regulation of myotome development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myotome development." [GOC:mah] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0061055 ! myotome development + +[Term] +id: GO:2000291 +name: regulation of myoblast proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myoblast proliferation." [GOC:mah] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0051450 ! myoblast proliferation + +[Term] +id: GO:2000292 +name: regulation of defecation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0044058 ! regulation of digestive system process +is_a: GO:0044062 ! regulation of excretion +relationship: regulates GO:0030421 ! defecation + +[Term] +id: GO:2000293 +name: negative regulation of defecation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051048 ! negative regulation of secretion +is_a: GO:0060457 ! negative regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +relationship: negatively_regulates GO:0030421 ! defecation + +[Term] +id: GO:2000294 +name: positive regulation of defecation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of defecation." [GOC:obol] +is_a: GO:0051047 ! positive regulation of secretion +is_a: GO:0060456 ! positive regulation of digestive system process +is_a: GO:2000292 ! regulation of defecation +relationship: positively_regulates GO:0030421 ! defecation + +[Term] +id: GO:2000295 +name: regulation of hydrogen peroxide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] +synonym: "regulation of detoxification of H2O2" RELATED [GOC:obol] +synonym: "regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] +synonym: "regulation of H2O2 catabolic process" EXACT [GOC:obol] +synonym: "regulation of H2O2 scavenging" RELATED [GOC:obol] +synonym: "regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] +synonym: "regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] +synonym: "regulation of hydrogen peroxide degradation" EXACT [GOC:obol] +synonym: "regulation of hydrogen peroxide removal" RELATED [GOC:obol] +synonym: "regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] +is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +relationship: regulates GO:0042744 ! hydrogen peroxide catabolic process + +[Term] +id: GO:2000296 +name: negative regulation of hydrogen peroxide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF] +synonym: "negative regulation of detoxification of H2O2" RELATED [GOC:obol] +synonym: "negative regulation of detoxification of hydrogen peroxide" RELATED [GOC:obol] +synonym: "negative regulation of H2O2 catabolic process" EXACT [GOC:obol] +synonym: "negative regulation of H2O2 scavenging" RELATED [GOC:obol] +synonym: "negative regulation of hydrogen peroxide breakdown" EXACT [GOC:obol] +synonym: "negative regulation of hydrogen peroxide catabolism" EXACT [GOC:obol] +synonym: "negative regulation of hydrogen peroxide degradation" EXACT [GOC:obol] +synonym: "negative regulation of hydrogen peroxide removal" RELATED [GOC:obol] +synonym: "negative regulation of hydrogen peroxide scavenging" RELATED [GOC:obol] +is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:2000295 ! regulation of hydrogen peroxide catabolic process +relationship: negatively_regulates GO:0042744 ! hydrogen peroxide catabolic process + +[Term] +id: GO:2000297 +name: negative regulation of synapse maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah] +synonym: "negative regulation of synaptic maturation" EXACT [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0090128 ! regulation of synapse maturation +is_a: GO:1905809 ! negative regulation of synapse organization +relationship: negatively_regulates GO:0060074 ! synapse maturation + +[Term] +id: GO:2000298 +name: regulation of Rho-dependent protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] +synonym: "regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] +synonym: "regulation of ROCK kinase activity" EXACT [GOC:obol] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:2000299 +name: negative regulation of Rho-dependent protein serine/threonine kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah] +synonym: "negative regulation of Rho-associated protein kinase activity" EXACT [GOC:obol] +synonym: "negative regulation of ROCK kinase activity" EXACT [GOC:obol] +is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity +is_a: GO:2000298 ! regulation of Rho-dependent protein serine/threonine kinase activity + +[Term] +id: GO:2000300 +name: regulation of synaptic vesicle exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] +subset: goslim_synapse +is_a: GO:0046928 ! regulation of neurotransmitter secretion +is_a: GO:1903305 ! regulation of regulated secretory pathway +relationship: regulates GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:2000301 +name: negative regulation of synaptic vesicle exocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] +is_a: GO:0046929 ! negative regulation of neurotransmitter secretion +is_a: GO:1903306 ! negative regulation of regulated secretory pathway +is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis +relationship: negatively_regulates GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:2000302 +name: positive regulation of synaptic vesicle exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol] +is_a: GO:0001956 ! positive regulation of neurotransmitter secretion +is_a: GO:1903307 ! positive regulation of regulated secretory pathway +is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis +relationship: positively_regulates GO:0016079 ! synaptic vesicle exocytosis + +[Term] +id: GO:2000303 +name: regulation of ceramide biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph] +synonym: "regulation of ceramide anabolism" EXACT [GOC:obol] +synonym: "regulation of ceramide biosynthesis" EXACT [GOC:obol] +synonym: "regulation of ceramide formation" EXACT [GOC:obol] +synonym: "regulation of ceramide synthesis" EXACT [GOC:obol] +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0090153 ! regulation of sphingolipid biosynthetic process +relationship: regulates GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:2000304 +name: positive regulation of ceramide biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph] +synonym: "positive regulation of ceramide anabolism" EXACT [GOC:obol] +synonym: "positive regulation of ceramide biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of ceramide formation" EXACT [GOC:obol] +synonym: "positive regulation of ceramide synthesis" EXACT [GOC:obol] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0090154 ! positive regulation of sphingolipid biosynthetic process +is_a: GO:2000303 ! regulation of ceramide biosynthetic process +relationship: positively_regulates GO:0046513 ! ceramide biosynthetic process + +[Term] +id: GO:2000305 +name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance +namespace: biological_process +def: "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol] +synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] +synonym: "semaphorin-plexin signaling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] +synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon guidance" EXACT [GOC:obol] +synonym: "semaphorin-plexin signalling pathway of regulation of photoreceptor cell axon pathfinding" EXACT [GOC:obol] +is_a: GO:0071526 ! semaphorin-plexin signaling pathway +relationship: part_of GO:2000289 ! regulation of photoreceptor cell axon guidance + +[Term] +id: GO:2000306 +name: positive regulation of photomorphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol] +synonym: "positive regulation of plant development in response to light" EXACT [GOC:obol] +is_a: GO:0010099 ! regulation of photomorphogenesis +is_a: GO:0048582 ! positive regulation of post-embryonic development +is_a: GO:0048584 ! positive regulation of response to stimulus +relationship: positively_regulates GO:0009640 ! photomorphogenesis + +[Term] +id: GO:2000307 +name: regulation of tumor necrosis factor (ligand) superfamily member 11 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] +synonym: "regulation of RANKL production" EXACT [GOC:obol] +synonym: "regulation of TNFSF11 production" EXACT [GOC:obol] +is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production +relationship: regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production + +[Term] +id: GO:2000308 +name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] +synonym: "negative regulation of RANKL production" EXACT [GOC:obol] +synonym: "negative regulation of TNFSF11 production" EXACT [GOC:obol] +is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production +is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production +relationship: negatively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production + +[Term] +id: GO:2000309 +name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah] +synonym: "positive regulation of RANKL production" EXACT [GOC:obol] +synonym: "positive regulation of TNFSF11 production" EXACT [GOC:obol] +is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production +is_a: GO:2000307 ! regulation of tumor necrosis factor (ligand) superfamily member 11 production +relationship: positively_regulates GO:0072535 ! tumor necrosis factor (ligand) superfamily member 11 production + +[Term] +id: GO:2000310 +name: regulation of NMDA receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF] +synonym: "regulation of N-methyl-D-aspartate selective glutamate receptor activity" EXACT [] +is_a: GO:0099601 ! regulation of neurotransmitter receptor activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:2000311 +name: regulation of AMPA receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity." [GOC:BHF] +synonym: "regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT [] +is_a: GO:0099601 ! regulation of neurotransmitter receptor activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:2000312 +name: regulation of kainate selective glutamate receptor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF] +is_a: GO:0099601 ! regulation of neurotransmitter receptor activity +is_a: GO:1901016 ! regulation of potassium ion transmembrane transporter activity +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:2000313 +name: regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] +synonym: "regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +relationship: regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:2000314 +name: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] +synonym: "negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] +is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +relationship: negatively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:2000315 +name: positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF] +synonym: "positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation" EXACT [GOC:obol] +is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000313 ! regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation +relationship: positively_regulates GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation + +[Term] +id: GO:2000316 +name: regulation of T-helper 17 type immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] +synonym: "regulation of Th17 immune response" EXACT [GOC:obol] +is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +relationship: regulates GO:0072538 ! T-helper 17 type immune response + +[Term] +id: GO:2000317 +name: negative regulation of T-helper 17 type immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] +synonym: "negative regulation of Th17 immune response" EXACT [GOC:obol] +is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:2000316 ! regulation of T-helper 17 type immune response +relationship: negatively_regulates GO:0072538 ! T-helper 17 type immune response + +[Term] +id: GO:2000318 +name: positive regulation of T-helper 17 type immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah] +synonym: "positive regulation of Th17 immune response" EXACT [GOC:obol] +is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains +is_a: GO:2000316 ! regulation of T-helper 17 type immune response +relationship: positively_regulates GO:0072538 ! T-helper 17 type immune response + +[Term] +id: GO:2000319 +name: regulation of T-helper 17 cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] +synonym: "regulation of T-helper 17 cell development" RELATED [GOC:obol] +is_a: GO:0045622 ! regulation of T-helper cell differentiation +is_a: GO:2000316 ! regulation of T-helper 17 type immune response +relationship: regulates GO:0072539 ! T-helper 17 cell differentiation + +[Term] +id: GO:2000320 +name: negative regulation of T-helper 17 cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] +synonym: "negative regulation of T-helper 17 cell development" RELATED [GOC:obol] +is_a: GO:0045623 ! negative regulation of T-helper cell differentiation +is_a: GO:2000317 ! negative regulation of T-helper 17 type immune response +is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation +relationship: negatively_regulates GO:0072539 ! T-helper 17 cell differentiation + +[Term] +id: GO:2000321 +name: positive regulation of T-helper 17 cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah] +synonym: "positive regulation of T-helper 17 cell development" RELATED [GOC:obol] +is_a: GO:0045624 ! positive regulation of T-helper cell differentiation +is_a: GO:2000318 ! positive regulation of T-helper 17 type immune response +is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation +relationship: positively_regulates GO:0072539 ! T-helper 17 cell differentiation + +[Term] +id: GO:2000322 +name: regulation of glucocorticoid receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] +synonym: "regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] +is_a: GO:0033143 ! regulation of intracellular steroid hormone receptor signaling pathway +relationship: regulates GO:0042921 ! glucocorticoid receptor signaling pathway + +[Term] +id: GO:2000323 +name: negative regulation of glucocorticoid receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] +synonym: "negative regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] +is_a: GO:0033144 ! negative regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway +relationship: negatively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway + +[Term] +id: GO:2000324 +name: positive regulation of glucocorticoid receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF] +synonym: "positive regulation of glucocorticoid receptor signalling pathway" EXACT [GOC:obol] +is_a: GO:0033145 ! positive regulation of intracellular steroid hormone receptor signaling pathway +is_a: GO:2000322 ! regulation of glucocorticoid receptor signaling pathway +relationship: positively_regulates GO:0042921 ! glucocorticoid receptor signaling pathway + +[Term] +id: GO:2000325 +name: obsolete regulation of nuclear receptor coactivator activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] +synonym: "regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] +synonym: "regulation of nuclear receptor transcription coactivator activity" EXACT [] +is_obsolete: true + +[Term] +id: GO:2000326 +name: obsolete negative regulation of nuclear receptor transcription coactivator activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] +comment: This term was obsoleted because it represents a molecular function. +synonym: "negative regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] +synonym: "negative regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] +is_obsolete: true +consider: GO:0140536 + +[Term] +id: GO:2000327 +name: obsolete positive regulation of nuclear receptor transcription coactivator activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF] +comment: This term was obsoleted because it represents a molecular function. +synonym: "positive regulation of ligand-dependent nuclear receptor transcription co-activator activity" EXACT [GOC:obol] +synonym: "positive regulation of ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] +is_obsolete: true +consider: GO:0030374 + +[Term] +id: GO:2000328 +name: regulation of T-helper 17 cell lineage commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] +synonym: "regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] +synonym: "regulation of Th17 cell lineage commitment" EXACT [GOC:obol] +synonym: "regulation of Th17 fate commitment" EXACT [GOC:obol] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:2000319 ! regulation of T-helper 17 cell differentiation +relationship: regulates GO:0072540 ! T-helper 17 cell lineage commitment + +[Term] +id: GO:2000329 +name: negative regulation of T-helper 17 cell lineage commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] +synonym: "negative regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] +synonym: "negative regulation of Th17 cell lineage commitment" EXACT [GOC:obol] +synonym: "negative regulation of Th17 fate commitment" EXACT [GOC:obol] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:2000320 ! negative regulation of T-helper 17 cell differentiation +is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment +relationship: negatively_regulates GO:0072540 ! T-helper 17 cell lineage commitment + +[Term] +id: GO:2000330 +name: positive regulation of T-helper 17 cell lineage commitment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah] +synonym: "positive regulation of T-helper 17 cell fate commitment" EXACT [GOC:obol] +synonym: "positive regulation of Th17 cell lineage commitment" EXACT [GOC:obol] +synonym: "positive regulation of Th17 fate commitment" EXACT [GOC:obol] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:2000321 ! positive regulation of T-helper 17 cell differentiation +is_a: GO:2000328 ! regulation of T-helper 17 cell lineage commitment +relationship: positively_regulates GO:0072540 ! T-helper 17 cell lineage commitment + +[Term] +id: GO:2000331 +name: regulation of terminal button organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah] +synonym: "regulation of bouton organization" EXACT [GOC:obol] +synonym: "regulation of presynaptic bouton organization" EXACT [GOC:obol] +synonym: "regulation of synaptic bouton organization" EXACT [GOC:obol] +synonym: "regulation of terminal bouton organization" EXACT [GOC:obol] +synonym: "regulation of terminal button organisation" EXACT [GOC:obol] +is_a: GO:0099174 ! regulation of presynapse organization +relationship: regulates GO:0072553 ! terminal button organization + +[Term] +id: GO:2000332 +name: regulation of blood microparticle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] +synonym: "regulation of microparticle generation" EXACT [GOC:obol] +synonym: "regulation of microparticle release" EXACT [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:0051128 ! regulation of cellular component organization +relationship: regulates GO:0072564 ! blood microparticle formation + +[Term] +id: GO:2000333 +name: negative regulation of blood microparticle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] +synonym: "negative regulation of microparticle generation" EXACT [GOC:obol] +synonym: "negative regulation of microparticle release" EXACT [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:2000332 ! regulation of blood microparticle formation +relationship: negatively_regulates GO:0072564 ! blood microparticle formation + +[Term] +id: GO:2000334 +name: positive regulation of blood microparticle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah] +synonym: "positive regulation of microparticle generation" EXACT [GOC:obol] +synonym: "positive regulation of microparticle release" EXACT [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:2000332 ! regulation of blood microparticle formation +relationship: positively_regulates GO:0072564 ! blood microparticle formation + +[Term] +id: GO:2000335 +name: regulation of endothelial microparticle formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] +synonym: "regulation of endothelial microparticle generation" EXACT [GOC:obol] +synonym: "regulation of endothelial microparticle release" EXACT [GOC:obol] +is_a: GO:2000332 ! regulation of blood microparticle formation +relationship: regulates GO:0072565 ! endothelial microparticle formation + +[Term] +id: GO:2000336 +name: negative regulation of endothelial microparticle formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] +synonym: "negative regulation of endothelial microparticle generation" EXACT [GOC:obol] +synonym: "negative regulation of endothelial microparticle release" EXACT [GOC:obol] +is_a: GO:2000333 ! negative regulation of blood microparticle formation +is_a: GO:2000335 ! regulation of endothelial microparticle formation +relationship: negatively_regulates GO:0072565 ! endothelial microparticle formation + +[Term] +id: GO:2000337 +name: positive regulation of endothelial microparticle formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah] +synonym: "positive regulation of endothelial microparticle generation" EXACT [GOC:obol] +synonym: "positive regulation of endothelial microparticle release" EXACT [GOC:obol] +is_a: GO:2000334 ! positive regulation of blood microparticle formation +is_a: GO:2000335 ! regulation of endothelial microparticle formation +relationship: positively_regulates GO:0072565 ! endothelial microparticle formation + +[Term] +id: GO:2000338 +name: regulation of chemokine (C-X-C motif) ligand 1 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] +synonym: "regulation of CXCL1 production" EXACT [GOC:obol] +synonym: "regulation of KC production" EXACT [GOC:obol] +synonym: "regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] +synonym: "regulation of SCYB1 production" EXACT [GOC:obol] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production + +[Term] +id: GO:2000339 +name: negative regulation of chemokine (C-X-C motif) ligand 1 production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] +synonym: "negative regulation of CXCL1 production" EXACT [GOC:obol] +synonym: "negative regulation of KC production" EXACT [GOC:obol] +synonym: "negative regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] +synonym: "negative regulation of SCYB1 production" EXACT [GOC:obol] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production +relationship: negatively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production + +[Term] +id: GO:2000340 +name: positive regulation of chemokine (C-X-C motif) ligand 1 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah] +synonym: "positive regulation of CXCL1 production" EXACT [GOC:obol] +synonym: "positive regulation of KC production" EXACT [GOC:obol] +synonym: "positive regulation of keratinocyte derived chemokine production" EXACT [GOC:obol] +synonym: "positive regulation of SCYB1 production" EXACT [GOC:obol] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:2000338 ! regulation of chemokine (C-X-C motif) ligand 1 production +relationship: positively_regulates GO:0072566 ! chemokine (C-X-C motif) ligand 1 production + +[Term] +id: GO:2000341 +name: regulation of chemokine (C-X-C motif) ligand 2 production +namespace: biological_process +alt_id: GO:0035926 +alt_id: GO:1904207 +def: "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "chemokine (C-C motif) ligand 2 secretion" NARROW [] +synonym: "regulation of CCL2 secretion" NARROW [GOC:TermGenie] +synonym: "regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] +synonym: "regulation of CXCL2 production" EXACT [GOC:obol] +synonym: "regulation of MIP-2 production" EXACT [GOC:obol] +synonym: "regulation of MIP2 production" EXACT [GOC:obol] +synonym: "regulation of SCYB2 production" EXACT [GOC:obol] +is_a: GO:0032642 ! regulation of chemokine production +relationship: regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production + +[Term] +id: GO:2000342 +name: negative regulation of chemokine (C-X-C motif) ligand 2 production +namespace: biological_process +alt_id: GO:1904208 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "inhibition of CCL2 secretion" NARROW [GOC:TermGenie] +synonym: "inhibition of chemokine (C-C motif) ligand 2 secretion" NARROW [GOC:TermGenie] +synonym: "negative regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] +synonym: "negative regulation of CXCL2 production" EXACT [GOC:obol] +synonym: "negative regulation of MIP-2 production" EXACT [GOC:obol] +synonym: "negative regulation of MIP2 production" EXACT [GOC:obol] +synonym: "negative regulation of SCYB2 production" EXACT [GOC:obol] +is_a: GO:0032682 ! negative regulation of chemokine production +is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production +relationship: negatively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production + +[Term] +id: GO:2000343 +name: positive regulation of chemokine (C-X-C motif) ligand 2 production +namespace: biological_process +alt_id: GO:1904209 +def: "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah] +synonym: "positive regulation of CCL2 secretion" EXACT [GOC:TermGenie] +synonym: "positive regulation of chemokine (C-C motif) ligand 2 secretion" NARROW [] +synonym: "positive regulation of CXCL2 production" EXACT [GOC:obol] +synonym: "positive regulation of MIP-2 production" EXACT [GOC:obol] +synonym: "positive regulation of MIP2 production" EXACT [GOC:obol] +synonym: "positive regulation of SCYB2 production" EXACT [GOC:obol] +is_a: GO:0032722 ! positive regulation of chemokine production +is_a: GO:2000341 ! regulation of chemokine (C-X-C motif) ligand 2 production +relationship: positively_regulates GO:0072567 ! chemokine (C-X-C motif) ligand 2 production + +[Term] +id: GO:2000344 +name: positive regulation of acrosome reaction +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol] +is_a: GO:0060046 ! regulation of acrosome reaction +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0007340 ! acrosome reaction + +[Term] +id: GO:2000345 +name: regulation of hepatocyte proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0072574 ! hepatocyte proliferation + +[Term] +id: GO:2000346 +name: negative regulation of hepatocyte proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:2000345 ! regulation of hepatocyte proliferation +relationship: negatively_regulates GO:0072574 ! hepatocyte proliferation + +[Term] +id: GO:2000347 +name: positive regulation of hepatocyte proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:2000345 ! regulation of hepatocyte proliferation +relationship: positively_regulates GO:0072574 ! hepatocyte proliferation + +[Term] +id: GO:2000348 +name: regulation of CD40 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah] +synonym: "regulation of CD40 signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0023035 ! CD40 signaling pathway + +[Term] +id: GO:2000349 +name: negative regulation of CD40 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] +synonym: "negative regulation of CD40 signalling pathway" EXACT [GOC:obol] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:2000348 ! regulation of CD40 signaling pathway +relationship: negatively_regulates GO:0023035 ! CD40 signaling pathway + +[Term] +id: GO:2000350 +name: positive regulation of CD40 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah] +synonym: "positive regulation of CD40 signalling pathway" EXACT [GOC:obol] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2000348 ! regulation of CD40 signaling pathway +relationship: positively_regulates GO:0023035 ! CD40 signaling pathway + +[Term] +id: GO:2000351 +name: regulation of endothelial cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis] +synonym: "regulation of apoptosis of endothelial cells" EXACT [GOC:obol] +synonym: "regulation of endothelial cell apoptosis" NARROW [] +synonym: "regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] +synonym: "regulation of killing of endothelial cells" EXACT [GOC:obol] +synonym: "regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] +synonym: "regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:0072577 ! endothelial cell apoptotic process + +[Term] +id: GO:2000352 +name: negative regulation of endothelial cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +synonym: "negative regulation of apoptosis of endothelial cells" EXACT [GOC:obol] +synonym: "negative regulation of endothelial cell apoptosis" NARROW [] +synonym: "negative regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of killing of endothelial cells" EXACT [GOC:obol] +synonym: "negative regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:2000351 ! regulation of endothelial cell apoptotic process +relationship: negatively_regulates GO:0072577 ! endothelial cell apoptotic process + +[Term] +id: GO:2000353 +name: positive regulation of endothelial cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis] +synonym: "positive regulation of apoptosis of endothelial cells" EXACT [GOC:obol] +synonym: "positive regulation of endothelial cell apoptosis" NARROW [] +synonym: "positive regulation of endothelial cell programmed cell death by apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of killing of endothelial cells" EXACT [GOC:obol] +synonym: "positive regulation of programmed cell death of endothelial cells by apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of programmed cell death, endothelial cells" EXACT [GOC:obol] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:2000351 ! regulation of endothelial cell apoptotic process +relationship: positively_regulates GO:0072577 ! endothelial cell apoptotic process + +[Term] +id: GO:2000354 +name: regulation of ovarian follicle development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol] +synonym: "regulation of follicular phase" RELATED [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0001541 ! ovarian follicle development + +[Term] +id: GO:2000355 +name: negative regulation of ovarian follicle development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol] +synonym: "negative regulation of follicular phase" RELATED [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000242 ! negative regulation of reproductive process +is_a: GO:2000354 ! regulation of ovarian follicle development +relationship: negatively_regulates GO:0001541 ! ovarian follicle development + +[Term] +id: GO:2000356 +name: regulation of kidney smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] +is_a: GO:0051150 ! regulation of smooth muscle cell differentiation +relationship: regulates GO:0072195 ! kidney smooth muscle cell differentiation + +[Term] +id: GO:2000357 +name: negative regulation of kidney smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] +is_a: GO:0051151 ! negative regulation of smooth muscle cell differentiation +is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation +relationship: negatively_regulates GO:0072195 ! kidney smooth muscle cell differentiation + +[Term] +id: GO:2000358 +name: positive regulation of kidney smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol] +is_a: GO:0051152 ! positive regulation of smooth muscle cell differentiation +is_a: GO:2000356 ! regulation of kidney smooth muscle cell differentiation +relationship: positively_regulates GO:0072195 ! kidney smooth muscle cell differentiation + +[Term] +id: GO:2000359 +name: regulation of binding of sperm to zona pellucida +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] +synonym: "regulation of ZPG binding" RELATED [GOC:obol] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0007339 ! binding of sperm to zona pellucida + +[Term] +id: GO:2000360 +name: negative regulation of binding of sperm to zona pellucida +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol] +synonym: "negative regulation of ZPG binding" RELATED [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:2000242 ! negative regulation of reproductive process +is_a: GO:2000359 ! regulation of binding of sperm to zona pellucida +relationship: negatively_regulates GO:0007339 ! binding of sperm to zona pellucida + +[Term] +id: GO:2000361 +name: regulation of prostaglandin-E synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] +synonym: "regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] +synonym: "regulation of endoperoxide isomerase activity" EXACT [GOC:obol] +synonym: "regulation of PGE isomerase activity" EXACT [GOC:obol] +synonym: "regulation of PGE2 isomerase activity" EXACT [GOC:obol] +synonym: "regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] +synonym: "regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] +synonym: "regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] +synonym: "regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] +synonym: "regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] +synonym: "regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] +synonym: "regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] +is_a: GO:0010911 ! regulation of isomerase activity + +[Term] +id: GO:2000362 +name: negative regulation of prostaglandin-E synthase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] +synonym: "negative regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of endoperoxide isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of PGE isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of PGE2 isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity + +[Term] +id: GO:2000363 +name: positive regulation of prostaglandin-E synthase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF] +synonym: "positive regulation of (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of endoperoxide isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of PGE isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of PGE2 isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of PGH-PGE isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of prostaglandin endoperoxide E isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of prostaglandin endoperoxide E2 isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of prostaglandin H-E isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of prostaglandin R-prostaglandin E isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of Prostaglandin-H(2) E-isomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of prostaglandin-H2 E-isomerase activity" EXACT [GOC:obol] +is_a: GO:0010912 ! positive regulation of isomerase activity +is_a: GO:2000361 ! regulation of prostaglandin-E synthase activity + +[Term] +id: GO:2000367 +name: regulation of acrosomal vesicle exocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] +synonym: "regulation of acrosomal granule exocytosis" RELATED [GOC:obol] +synonym: "regulation of acrosome exocytosis" EXACT [GOC:obol] +is_a: GO:0017158 ! regulation of calcium ion-dependent exocytosis +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0060478 ! acrosomal vesicle exocytosis + +[Term] +id: GO:2000368 +name: positive regulation of acrosomal vesicle exocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol] +synonym: "positive regulation of acrosomal granule exocytosis" RELATED [GOC:obol] +synonym: "positive regulation of acrosome exocytosis" EXACT [GOC:obol] +is_a: GO:0045956 ! positive regulation of calcium ion-dependent exocytosis +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2000367 ! regulation of acrosomal vesicle exocytosis +relationship: positively_regulates GO:0060478 ! acrosomal vesicle exocytosis + +[Term] +id: GO:2000369 +name: regulation of clathrin-dependent endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah] +synonym: "regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] +synonym: "regulation of clathrin-mediated endocytosis" EXACT [] +is_a: GO:0048259 ! regulation of receptor-mediated endocytosis +relationship: regulates GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:2000370 +name: positive regulation of clathrin-dependent endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah] +synonym: "positive regulation of clathrin coated pit-dependent endocytosis" EXACT [GOC:obol] +synonym: "positive regulation of clathrin-mediated endocytosis" EXACT [] +is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis +is_a: GO:2000369 ! regulation of clathrin-dependent endocytosis +relationship: positively_regulates GO:0072583 ! clathrin-dependent endocytosis + +[Term] +id: GO:2000371 +name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] +synonym: "regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] +synonym: "regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] +synonym: "regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] +synonym: "regulation of DNA topoisomerase II" RELATED [GOC:obol] +synonym: "regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] +synonym: "regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] +synonym: "regulation of topoisomerase" RELATED [GOC:obol] +synonym: "regulation of topoisomerase II" EXACT [GOC:obol] +synonym: "regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] +is_a: GO:0010911 ! regulation of isomerase activity +is_a: GO:0043462 ! regulation of ATP-dependent activity + +[Term] +id: GO:2000372 +name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] +synonym: "negative regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] +synonym: "negative regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] +synonym: "negative regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] +synonym: "negative regulation of DNA topoisomerase II" RELATED [GOC:obol] +synonym: "negative regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] +synonym: "negative regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] +synonym: "negative regulation of topoisomerase" RELATED [GOC:obol] +synonym: "negative regulation of topoisomerase II" EXACT [GOC:obol] +synonym: "negative regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] +is_a: GO:0032780 ! negative regulation of ATP-dependent activity +is_a: GO:0043086 ! negative regulation of catalytic activity +is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity + +[Term] +id: GO:2000373 +name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] +synonym: "positive regulation of deoxyribonucleate topoisomerase" RELATED [GOC:obol] +synonym: "positive regulation of deoxyribonucleic topoisomerase activity" EXACT [GOC:obol] +synonym: "positive regulation of DNA topoisomerase (ATP-hydrolysing)" RELATED [GOC:obol] +synonym: "positive regulation of DNA topoisomerase II" RELATED [GOC:obol] +synonym: "positive regulation of DNA topoisomerase IV activity" EXACT [GOC:obol] +synonym: "positive regulation of DNA topoisomerase type II activity" EXACT [GOC:obol] +synonym: "positive regulation of topoisomerase" RELATED [GOC:obol] +synonym: "positive regulation of topoisomerase II" EXACT [GOC:obol] +synonym: "positive regulation of type II DNA topoisomerase activity" EXACT [GOC:obol] +is_a: GO:0010912 ! positive regulation of isomerase activity +is_a: GO:0032781 ! positive regulation of ATP-dependent activity +is_a: GO:2000371 ! regulation of DNA topoisomerase (ATP-hydrolyzing) activity + +[Term] +id: GO:2000374 +name: regulation of oxygen metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of oxygen metabolic process." [GOC:mah] +synonym: "regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] +synonym: "regulation of oxygen metabolism" EXACT [GOC:obol] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0072592 ! oxygen metabolic process + +[Term] +id: GO:2000375 +name: negative regulation of oxygen metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah] +synonym: "negative regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] +synonym: "negative regulation of oxygen metabolism" EXACT [GOC:obol] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:2000374 ! regulation of oxygen metabolic process +relationship: negatively_regulates GO:0072592 ! oxygen metabolic process + +[Term] +id: GO:2000376 +name: positive regulation of oxygen metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah] +synonym: "positive regulation of diatomic oxygen metabolic process" EXACT [GOC:obol] +synonym: "positive regulation of oxygen metabolism" EXACT [GOC:obol] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:2000374 ! regulation of oxygen metabolic process +relationship: positively_regulates GO:0072592 ! oxygen metabolic process + +[Term] +id: GO:2000377 +name: regulation of reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] +synonym: "regulation of reactive oxygen species metabolism" EXACT [GOC:obol] +synonym: "regulation of ROS metabolic process" EXACT [GOC:obol] +is_a: GO:0031323 ! regulation of cellular metabolic process +relationship: regulates GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:2000378 +name: negative regulation of reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] +synonym: "negative regulation of reactive oxygen species metabolism" EXACT [GOC:obol] +synonym: "negative regulation of ROS metabolic process" EXACT [GOC:obol] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process +relationship: negatively_regulates GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:2000379 +name: positive regulation of reactive oxygen species metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah] +synonym: "positive regulation of reactive oxygen species metabolism" EXACT [GOC:obol] +synonym: "positive regulation of ROS metabolic process" EXACT [GOC:obol] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process +relationship: positively_regulates GO:0072593 ! reactive oxygen species metabolic process + +[Term] +id: GO:2000380 +name: regulation of mesoderm development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesoderm development." [GOC:BHF] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0007498 ! mesoderm development + +[Term] +id: GO:2000381 +name: negative regulation of mesoderm development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000380 ! regulation of mesoderm development +relationship: negatively_regulates GO:0007498 ! mesoderm development + +[Term] +id: GO:2000382 +name: positive regulation of mesoderm development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000380 ! regulation of mesoderm development +relationship: positively_regulates GO:0007498 ! mesoderm development + +[Term] +id: GO:2000383 +name: regulation of ectoderm development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ectoderm development." [GOC:BHF] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0007398 ! ectoderm development + +[Term] +id: GO:2000384 +name: negative regulation of ectoderm development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000383 ! regulation of ectoderm development +relationship: negatively_regulates GO:0007398 ! ectoderm development + +[Term] +id: GO:2000385 +name: positive regulation of ectoderm development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000383 ! regulation of ectoderm development +relationship: positively_regulates GO:0007398 ! ectoderm development + +[Term] +id: GO:2000386 +name: positive regulation of ovarian follicle development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol] +synonym: "positive regulation of follicular phase" RELATED [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2000354 ! regulation of ovarian follicle development +relationship: positively_regulates GO:0001541 ! ovarian follicle development + +[Term] +id: GO:2000387 +name: regulation of antral ovarian follicle growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] +is_a: GO:0048638 ! regulation of developmental growth +is_a: GO:2000241 ! regulation of reproductive process +relationship: regulates GO:0001547 ! antral ovarian follicle growth + +[Term] +id: GO:2000388 +name: positive regulation of antral ovarian follicle growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol] +is_a: GO:0048639 ! positive regulation of developmental growth +is_a: GO:2000243 ! positive regulation of reproductive process +is_a: GO:2000387 ! regulation of antral ovarian follicle growth +relationship: positively_regulates GO:0001547 ! antral ovarian follicle growth + +[Term] +id: GO:2000389 +name: regulation of neutrophil extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil extravasation." [GOC:mah] +is_a: GO:0002691 ! regulation of cellular extravasation +is_a: GO:1902622 ! regulation of neutrophil migration +relationship: regulates GO:0072672 ! neutrophil extravasation + +[Term] +id: GO:2000390 +name: negative regulation of neutrophil extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] +is_a: GO:0002692 ! negative regulation of cellular extravasation +is_a: GO:1902623 ! negative regulation of neutrophil migration +is_a: GO:2000389 ! regulation of neutrophil extravasation +relationship: negatively_regulates GO:0072672 ! neutrophil extravasation + +[Term] +id: GO:2000391 +name: positive regulation of neutrophil extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah] +is_a: GO:0002693 ! positive regulation of cellular extravasation +is_a: GO:1902624 ! positive regulation of neutrophil migration +is_a: GO:2000389 ! regulation of neutrophil extravasation +relationship: positively_regulates GO:0072672 ! neutrophil extravasation + +[Term] +id: GO:2000392 +name: regulation of lamellipodium morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah] +synonym: "regulation of lamellipodium organization" RELATED [GOC:obol] +is_a: GO:0022604 ! regulation of cell morphogenesis +is_a: GO:1902743 ! regulation of lamellipodium organization +relationship: regulates GO:0072673 ! lamellipodium morphogenesis + +[Term] +id: GO:2000393 +name: negative regulation of lamellipodium morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] +synonym: "negative regulation of lamellipodium organization" RELATED [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:1902744 ! negative regulation of lamellipodium organization +is_a: GO:2000392 ! regulation of lamellipodium morphogenesis +relationship: negatively_regulates GO:0072673 ! lamellipodium morphogenesis + +[Term] +id: GO:2000394 +name: positive regulation of lamellipodium morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah] +synonym: "positive regulation of lamellipodium organization" RELATED [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:1902745 ! positive regulation of lamellipodium organization +is_a: GO:2000392 ! regulation of lamellipodium morphogenesis +relationship: positively_regulates GO:0072673 ! lamellipodium morphogenesis + +[Term] +id: GO:2000395 +name: regulation of ubiquitin-dependent endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] +synonym: "regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] +is_a: GO:0030100 ! regulation of endocytosis +is_a: GO:0051223 ! regulation of protein transport +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0070086 ! ubiquitin-dependent endocytosis + +[Term] +id: GO:2000396 +name: negative regulation of ubiquitin-dependent endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] +synonym: "negative regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:0051224 ! negative regulation of protein transport +is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis +relationship: negatively_regulates GO:0070086 ! ubiquitin-dependent endocytosis + +[Term] +id: GO:2000397 +name: positive regulation of ubiquitin-dependent endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah] +synonym: "positive regulation of ubiquitin-mediated endocytosis" EXACT [GOC:obol] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:0051222 ! positive regulation of protein transport +is_a: GO:2000395 ! regulation of ubiquitin-dependent endocytosis +relationship: positively_regulates GO:0070086 ! ubiquitin-dependent endocytosis + +[Term] +id: GO:2000398 +name: regulation of thymocyte aggregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thymocyte aggregation." [GOC:mah] +synonym: "regulation of immature T cell aggregation" RELATED [GOC:obol] +synonym: "regulation of immature T-cell aggregation" RELATED [GOC:obol] +synonym: "regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] +synonym: "regulation of T cell precursor aggregation" EXACT [GOC:obol] +synonym: "regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: regulates GO:0071594 ! thymocyte aggregation + +[Term] +id: GO:2000399 +name: negative regulation of thymocyte aggregation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] +synonym: "negative regulation of immature T cell aggregation" RELATED [GOC:obol] +synonym: "negative regulation of immature T-cell aggregation" RELATED [GOC:obol] +synonym: "negative regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] +synonym: "negative regulation of T cell precursor aggregation" EXACT [GOC:obol] +synonym: "negative regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion +is_a: GO:2000398 ! regulation of thymocyte aggregation +relationship: negatively_regulates GO:0071594 ! thymocyte aggregation + +[Term] +id: GO:2000400 +name: positive regulation of thymocyte aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah] +synonym: "positive regulation of immature T cell aggregation" RELATED [GOC:obol] +synonym: "positive regulation of immature T-cell aggregation" RELATED [GOC:obol] +synonym: "positive regulation of immature T-lymphocyte aggregation" EXACT [GOC:obol] +synonym: "positive regulation of T cell precursor aggregation" EXACT [GOC:obol] +synonym: "positive regulation of thymic lymphocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion +is_a: GO:2000398 ! regulation of thymocyte aggregation +relationship: positively_regulates GO:0071594 ! thymocyte aggregation + +[Term] +id: GO:2000401 +name: regulation of lymphocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lymphocyte migration." [GOC:mah] +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: regulates GO:0072676 ! lymphocyte migration + +[Term] +id: GO:2000402 +name: negative regulation of lymphocyte migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah] +is_a: GO:0071676 ! negative regulation of mononuclear cell migration +is_a: GO:2000401 ! regulation of lymphocyte migration +relationship: negatively_regulates GO:0072676 ! lymphocyte migration + +[Term] +id: GO:2000403 +name: positive regulation of lymphocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah] +is_a: GO:0071677 ! positive regulation of mononuclear cell migration +is_a: GO:2000401 ! regulation of lymphocyte migration +relationship: positively_regulates GO:0072676 ! lymphocyte migration + +[Term] +id: GO:2000404 +name: regulation of T cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell migration." [GOC:mah] +synonym: "regulation of T lymphocyte migration" EXACT [GOC:obol] +synonym: "regulation of T-cell migration" EXACT [GOC:obol] +synonym: "regulation of T-lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000401 ! regulation of lymphocyte migration +relationship: regulates GO:0072678 ! T cell migration + +[Term] +id: GO:2000405 +name: negative regulation of T cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah] +synonym: "negative regulation of T lymphocyte migration" EXACT [GOC:obol] +synonym: "negative regulation of T-cell migration" EXACT [GOC:obol] +synonym: "negative regulation of T-lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000402 ! negative regulation of lymphocyte migration +is_a: GO:2000404 ! regulation of T cell migration +relationship: negatively_regulates GO:0072678 ! T cell migration + +[Term] +id: GO:2000406 +name: positive regulation of T cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah] +synonym: "positive regulation of T lymphocyte migration" EXACT [GOC:obol] +synonym: "positive regulation of T-cell migration" EXACT [GOC:obol] +synonym: "positive regulation of T-lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000403 ! positive regulation of lymphocyte migration +is_a: GO:2000404 ! regulation of T cell migration +relationship: positively_regulates GO:0072678 ! T cell migration + +[Term] +id: GO:2000407 +name: regulation of T cell extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell extravasation." [GOC:mah] +synonym: "regulation of T lymphocyte extravasation" EXACT [GOC:obol] +synonym: "regulation of T-cell extravasation" EXACT [GOC:obol] +synonym: "regulation of T-lymphocyte extravasation" EXACT [GOC:obol] +is_a: GO:0002691 ! regulation of cellular extravasation +is_a: GO:2000404 ! regulation of T cell migration +relationship: regulates GO:0072683 ! T cell extravasation + +[Term] +id: GO:2000408 +name: negative regulation of T cell extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] +synonym: "negative regulation of T lymphocyte extravasation" EXACT [GOC:obol] +synonym: "negative regulation of T-cell extravasation" EXACT [GOC:obol] +synonym: "negative regulation of T-lymphocyte extravasation" EXACT [GOC:obol] +is_a: GO:0002692 ! negative regulation of cellular extravasation +is_a: GO:2000405 ! negative regulation of T cell migration +is_a: GO:2000407 ! regulation of T cell extravasation +relationship: negatively_regulates GO:0072683 ! T cell extravasation + +[Term] +id: GO:2000409 +name: positive regulation of T cell extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah] +synonym: "positive regulation of T lymphocyte extravasation" EXACT [GOC:obol] +synonym: "positive regulation of T-cell extravasation" EXACT [GOC:obol] +synonym: "positive regulation of T-lymphocyte extravasation" EXACT [GOC:obol] +is_a: GO:0002693 ! positive regulation of cellular extravasation +is_a: GO:2000406 ! positive regulation of T cell migration +is_a: GO:2000407 ! regulation of T cell extravasation +relationship: positively_regulates GO:0072683 ! T cell extravasation + +[Term] +id: GO:2000410 +name: regulation of thymocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thymocyte migration." [GOC:mah] +synonym: "regulation of immature T cell migration" RELATED [GOC:obol] +synonym: "regulation of immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "regulation of immature T-cell migration" RELATED [GOC:obol] +synonym: "regulation of immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "regulation of thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000404 ! regulation of T cell migration +relationship: regulates GO:0072679 ! thymocyte migration + +[Term] +id: GO:2000411 +name: negative regulation of thymocyte migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah] +synonym: "negative regulation of immature T cell migration" RELATED [GOC:obol] +synonym: "negative regulation of immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "negative regulation of immature T-cell migration" RELATED [GOC:obol] +synonym: "negative regulation of immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "negative regulation of thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000405 ! negative regulation of T cell migration +is_a: GO:2000410 ! regulation of thymocyte migration +relationship: negatively_regulates GO:0072679 ! thymocyte migration + +[Term] +id: GO:2000412 +name: positive regulation of thymocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah] +synonym: "positive regulation of immature T cell migration" RELATED [GOC:obol] +synonym: "positive regulation of immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "positive regulation of immature T-cell migration" RELATED [GOC:obol] +synonym: "positive regulation of immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "positive regulation of thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000406 ! positive regulation of T cell migration +is_a: GO:2000410 ! regulation of thymocyte migration +relationship: positively_regulates GO:0072679 ! thymocyte migration + +[Term] +id: GO:2000413 +name: regulation of fibronectin-dependent thymocyte migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah] +synonym: "regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] +synonym: "regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] +synonym: "regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000410 ! regulation of thymocyte migration +relationship: regulates GO:0072681 ! fibronectin-dependent thymocyte migration + +[Term] +id: GO:2000414 +name: negative regulation of fibronectin-dependent thymocyte migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] +synonym: "negative regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] +synonym: "negative regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "negative regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] +synonym: "negative regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "negative regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000411 ! negative regulation of thymocyte migration +is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration +relationship: negatively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration + +[Term] +id: GO:2000415 +name: positive regulation of fibronectin-dependent thymocyte migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah] +synonym: "positive regulation of fibronectin-dependent immature T cell migration" RELATED [GOC:obol] +synonym: "positive regulation of fibronectin-dependent immature T lymphocyte migration" RELATED [GOC:obol] +synonym: "positive regulation of fibronectin-dependent immature T-cell migration" RELATED [GOC:obol] +synonym: "positive regulation of fibronectin-dependent immature T-lymphocyte migration" RELATED [GOC:obol] +synonym: "positive regulation of fibronectin-dependent thymic lymphocyte migration" EXACT [GOC:obol] +is_a: GO:2000412 ! positive regulation of thymocyte migration +is_a: GO:2000413 ! regulation of fibronectin-dependent thymocyte migration +relationship: positively_regulates GO:0072681 ! fibronectin-dependent thymocyte migration + +[Term] +id: GO:2000416 +name: regulation of eosinophil migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil migration." [GOC:mah] +is_a: GO:0002685 ! regulation of leukocyte migration +relationship: regulates GO:0072677 ! eosinophil migration + +[Term] +id: GO:2000417 +name: negative regulation of eosinophil migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah] +is_a: GO:0002686 ! negative regulation of leukocyte migration +is_a: GO:2000416 ! regulation of eosinophil migration +relationship: negatively_regulates GO:0072677 ! eosinophil migration + +[Term] +id: GO:2000418 +name: positive regulation of eosinophil migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah] +is_a: GO:0002687 ! positive regulation of leukocyte migration +is_a: GO:2000416 ! regulation of eosinophil migration +relationship: positively_regulates GO:0072677 ! eosinophil migration + +[Term] +id: GO:2000419 +name: regulation of eosinophil extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil extravasation." [GOC:mah] +is_a: GO:0002691 ! regulation of cellular extravasation +is_a: GO:2000416 ! regulation of eosinophil migration +relationship: regulates GO:0072682 ! eosinophil extravasation + +[Term] +id: GO:2000420 +name: negative regulation of eosinophil extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] +is_a: GO:0002692 ! negative regulation of cellular extravasation +is_a: GO:2000417 ! negative regulation of eosinophil migration +is_a: GO:2000419 ! regulation of eosinophil extravasation +relationship: negatively_regulates GO:0072682 ! eosinophil extravasation + +[Term] +id: GO:2000421 +name: positive regulation of eosinophil extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah] +is_a: GO:0002693 ! positive regulation of cellular extravasation +is_a: GO:2000418 ! positive regulation of eosinophil migration +is_a: GO:2000419 ! regulation of eosinophil extravasation +relationship: positively_regulates GO:0072682 ! eosinophil extravasation + +[Term] +id: GO:2000422 +name: regulation of eosinophil chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] +is_a: GO:0071622 ! regulation of granulocyte chemotaxis +is_a: GO:2000416 ! regulation of eosinophil migration +relationship: regulates GO:0048245 ! eosinophil chemotaxis + +[Term] +id: GO:2000423 +name: negative regulation of eosinophil chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] +is_a: GO:0071623 ! negative regulation of granulocyte chemotaxis +is_a: GO:2000417 ! negative regulation of eosinophil migration +is_a: GO:2000422 ! regulation of eosinophil chemotaxis +relationship: negatively_regulates GO:0048245 ! eosinophil chemotaxis + +[Term] +id: GO:2000424 +name: positive regulation of eosinophil chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol] +is_a: GO:0071624 ! positive regulation of granulocyte chemotaxis +is_a: GO:2000418 ! positive regulation of eosinophil migration +is_a: GO:2000422 ! regulation of eosinophil chemotaxis +relationship: positively_regulates GO:0048245 ! eosinophil chemotaxis + +[Term] +id: GO:2000425 +name: regulation of apoptotic cell clearance +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] +synonym: "regulation of apoptotic cell removal" EXACT [GOC:obol] +synonym: "regulation of efferocytosis" EXACT [GOC:obol] +synonym: "regulation of programmed cell clearance" EXACT [GOC:obol] +is_a: GO:0050764 ! regulation of phagocytosis +relationship: regulates GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:2000426 +name: negative regulation of apoptotic cell clearance +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] +synonym: "negative regulation of apoptotic cell removal" EXACT [GOC:obol] +synonym: "negative regulation of efferocytosis" EXACT [GOC:obol] +synonym: "negative regulation of programmed cell clearance" EXACT [GOC:obol] +is_a: GO:0050765 ! negative regulation of phagocytosis +is_a: GO:2000425 ! regulation of apoptotic cell clearance +relationship: negatively_regulates GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:2000427 +name: positive regulation of apoptotic cell clearance +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol] +synonym: "positive regulation of apoptotic cell removal" EXACT [GOC:obol] +synonym: "positive regulation of efferocytosis" EXACT [GOC:obol] +synonym: "positive regulation of programmed cell clearance" EXACT [GOC:obol] +is_a: GO:0050766 ! positive regulation of phagocytosis +is_a: GO:2000425 ! regulation of apoptotic cell clearance +relationship: positively_regulates GO:0043277 ! apoptotic cell clearance + +[Term] +id: GO:2000428 +name: regulation of neutrophil aggregation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] +synonym: "regulation of neutrocyte aggregation" EXACT [GOC:obol] +synonym: "regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] +synonym: "regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: regulates GO:0070488 ! neutrophil aggregation + +[Term] +id: GO:2000429 +name: negative regulation of neutrophil aggregation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] +synonym: "negative regulation of neutrocyte aggregation" EXACT [GOC:obol] +synonym: "negative regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] +synonym: "negative regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903038 ! negative regulation of leukocyte cell-cell adhesion +is_a: GO:2000428 ! regulation of neutrophil aggregation +relationship: negatively_regulates GO:0070488 ! neutrophil aggregation + +[Term] +id: GO:2000430 +name: positive regulation of neutrophil aggregation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF] +synonym: "positive regulation of neutrocyte aggregation" EXACT [GOC:obol] +synonym: "positive regulation of neutrophil leucocyte aggregation" EXACT [GOC:obol] +synonym: "positive regulation of neutrophilic leukocyte aggregation" EXACT [GOC:obol] +is_a: GO:1903039 ! positive regulation of leukocyte cell-cell adhesion +is_a: GO:2000428 ! regulation of neutrophil aggregation +relationship: positively_regulates GO:0070488 ! neutrophil aggregation + +[Term] +id: GO:2000431 +name: regulation of cytokinesis, actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] +synonym: "regulation of contractile ring assembly" EXACT [GOC:obol] +is_a: GO:0032954 ! regulation of cytokinetic process +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:0110020 ! regulation of actomyosin structure organization +relationship: regulates GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:2000432 +name: negative regulation of cytokinesis, actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] +synonym: "negative regulation of contractile ring assembly" EXACT [GOC:obol] +is_a: GO:0032466 ! negative regulation of cytokinesis +is_a: GO:0051494 ! negative regulation of cytoskeleton organization +is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly +relationship: negatively_regulates GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:2000433 +name: positive regulation of cytokinesis, actomyosin contractile ring assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol] +synonym: "positive regulation of contractile ring assembly" EXACT [GOC:obol] +is_a: GO:0032467 ! positive regulation of cytokinesis +is_a: GO:0051495 ! positive regulation of cytoskeleton organization +is_a: GO:2000431 ! regulation of cytokinesis, actomyosin contractile ring assembly +relationship: positively_regulates GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:2000434 +name: regulation of protein neddylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein neddylation." [GOC:obol] +synonym: "regulation of RUB1-protein conjugation" EXACT [GOC:obol] +is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal +relationship: regulates GO:0045116 ! protein neddylation + +[Term] +id: GO:2000435 +name: negative regulation of protein neddylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol] +synonym: "negative regulation of RUB1-protein conjugation" EXACT [GOC:obol] +is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal +is_a: GO:2000434 ! regulation of protein neddylation +relationship: negatively_regulates GO:0045116 ! protein neddylation + +[Term] +id: GO:2000436 +name: positive regulation of protein neddylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol] +synonym: "positive regulation of RUB1-protein conjugation" EXACT [GOC:obol] +is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal +is_a: GO:2000434 ! regulation of protein neddylation +relationship: positively_regulates GO:0045116 ! protein neddylation + +[Term] +id: GO:2000437 +name: regulation of monocyte extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of monocyte extravasation." [GOC:obol] +is_a: GO:0002691 ! regulation of cellular extravasation +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: regulates GO:0035696 ! monocyte extravasation + +[Term] +id: GO:2000438 +name: negative regulation of monocyte extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol] +is_a: GO:0002692 ! negative regulation of cellular extravasation +is_a: GO:0071676 ! negative regulation of mononuclear cell migration +is_a: GO:2000437 ! regulation of monocyte extravasation +relationship: negatively_regulates GO:0035696 ! monocyte extravasation + +[Term] +id: GO:2000439 +name: positive regulation of monocyte extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol] +is_a: GO:0002693 ! positive regulation of cellular extravasation +is_a: GO:0071677 ! positive regulation of mononuclear cell migration +is_a: GO:2000437 ! regulation of monocyte extravasation +relationship: positively_regulates GO:0035696 ! monocyte extravasation + +[Term] +id: GO:2000440 +name: regulation of toll-like receptor 15 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] +synonym: "regulation of TLR15 signaling pathway" EXACT [GOC:obol] +synonym: "regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0035681 ! toll-like receptor 15 signaling pathway + +[Term] +id: GO:2000441 +name: negative regulation of toll-like receptor 15 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] +synonym: "negative regulation of TLR15 signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway +relationship: negatively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway + +[Term] +id: GO:2000442 +name: positive regulation of toll-like receptor 15 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol] +synonym: "positive regulation of TLR15 signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of toll-like receptor 15 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:2000440 ! regulation of toll-like receptor 15 signaling pathway +relationship: positively_regulates GO:0035681 ! toll-like receptor 15 signaling pathway + +[Term] +id: GO:2000443 +name: regulation of toll-like receptor 21 signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] +synonym: "regulation of TLR21 signaling pathway" EXACT [GOC:obol] +synonym: "regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034121 ! regulation of toll-like receptor signaling pathway +relationship: regulates GO:0035682 ! toll-like receptor 21 signaling pathway + +[Term] +id: GO:2000444 +name: negative regulation of toll-like receptor 21 signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] +synonym: "negative regulation of TLR21 signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034122 ! negative regulation of toll-like receptor signaling pathway +is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway +relationship: negatively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway + +[Term] +id: GO:2000445 +name: positive regulation of toll-like receptor 21 signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol] +synonym: "positive regulation of TLR21 signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of toll-like receptor 21 signalling pathway" EXACT [GOC:mah] +is_a: GO:0034123 ! positive regulation of toll-like receptor signaling pathway +is_a: GO:2000443 ! regulation of toll-like receptor 21 signaling pathway +relationship: positively_regulates GO:0035682 ! toll-like receptor 21 signaling pathway + +[Term] +id: GO:2000446 +name: regulation of macrophage migration inhibitory factor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] +synonym: "regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] +synonym: "regulation of MIF signaling pathway" EXACT [GOC:obol] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway + +[Term] +id: GO:2000447 +name: negative regulation of macrophage migration inhibitory factor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] +synonym: "negative regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of MIF signaling pathway" EXACT [GOC:obol] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway +relationship: negatively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway + +[Term] +id: GO:2000448 +name: positive regulation of macrophage migration inhibitory factor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol] +synonym: "positive regulation of macrophage migration inhibitory factor signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of MIF signaling pathway" EXACT [GOC:obol] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:2000446 ! regulation of macrophage migration inhibitory factor signaling pathway +relationship: positively_regulates GO:0035691 ! macrophage migration inhibitory factor signaling pathway + +[Term] +id: GO:2000449 +name: regulation of CD8-positive, alpha-beta T cell extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] +is_a: GO:2000407 ! regulation of T cell extravasation +relationship: regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:2000450 +name: negative regulation of CD8-positive, alpha-beta T cell extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] +is_a: GO:2000408 ! negative regulation of T cell extravasation +is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation +relationship: negatively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:2000451 +name: positive regulation of CD8-positive, alpha-beta T cell extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol] +is_a: GO:2000409 ! positive regulation of T cell extravasation +is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation +relationship: positively_regulates GO:0035697 ! CD8-positive, alpha-beta T cell extravasation + +[Term] +id: GO:2000452 +name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] +is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation +relationship: regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation + +[Term] +id: GO:2000453 +name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] +is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation +is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation +relationship: negatively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation + +[Term] +id: GO:2000454 +name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol] +is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation +is_a: GO:2000452 ! regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation +relationship: positively_regulates GO:0035698 ! CD8-positive, alpha-beta cytotoxic T cell extravasation + +[Term] +id: GO:2000455 +name: regulation of T-helper 17 cell extravasation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] +is_a: GO:2000449 ! regulation of CD8-positive, alpha-beta T cell extravasation +relationship: regulates GO:0035699 ! T-helper 17 cell extravasation + +[Term] +id: GO:2000456 +name: negative regulation of T-helper 17 cell extravasation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] +is_a: GO:2000450 ! negative regulation of CD8-positive, alpha-beta T cell extravasation +is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation +relationship: negatively_regulates GO:0035699 ! T-helper 17 cell extravasation + +[Term] +id: GO:2000457 +name: positive regulation of T-helper 17 cell extravasation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol] +is_a: GO:2000451 ! positive regulation of CD8-positive, alpha-beta T cell extravasation +is_a: GO:2000455 ! regulation of T-helper 17 cell extravasation +relationship: positively_regulates GO:0035699 ! T-helper 17 cell extravasation + +[Term] +id: GO:2000458 +name: regulation of astrocyte chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] +is_a: GO:0050920 ! regulation of chemotaxis +is_a: GO:1903975 ! regulation of glial cell migration +relationship: regulates GO:0035700 ! astrocyte chemotaxis + +[Term] +id: GO:2000459 +name: negative regulation of astrocyte chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:1903976 ! negative regulation of glial cell migration +is_a: GO:2000458 ! regulation of astrocyte chemotaxis +relationship: negatively_regulates GO:0035700 ! astrocyte chemotaxis + +[Term] +id: GO:2000460 +name: obsolete regulation of eukaryotic cell surface binding +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] +comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. +synonym: "regulation of eukaryotic cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0031347 +consider: GO:1900120 + +[Term] +id: GO:2000461 +name: obsolete negative regulation of eukaryotic cell surface binding +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] +comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. +synonym: "negative regulation of eukaryotic cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0031347 +consider: GO:1900121 + +[Term] +id: GO:2000462 +name: obsolete positive regulation of eukaryotic cell surface binding +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol] +comment: This term was made obsolete because the cell surface binding terms are ambiguous grouping terms and were causing confusion. +synonym: "positive regulation of eukaryotic cell surface binding" EXACT [] +is_obsolete: true +consider: GO:0031347 +consider: GO:1900122 + +[Term] +id: GO:2000463 +name: positive regulation of excitatory postsynaptic potential +namespace: biological_process +def: "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF] +synonym: "positive regulation of EPSP" RELATED [GOC:bf, GOC:obol] +synonym: "positive regulation of excitatory post-synaptic membrane potential" EXACT [] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0098815 ! modulation of excitatory postsynaptic potential +relationship: positively_regulates GO:0060079 ! excitatory postsynaptic potential + +[Term] +id: GO:2000464 +name: positive regulation of astrocyte chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol] +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:1903977 ! positive regulation of glial cell migration +is_a: GO:2000458 ! regulation of astrocyte chemotaxis +relationship: positively_regulates GO:0035700 ! astrocyte chemotaxis + +[Term] +id: GO:2000465 +name: regulation of glycogen (starch) synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] +synonym: "regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] +synonym: "regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +synonym: "regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] +synonym: "regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] +synonym: "regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] +synonym: "regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:2000466 +name: negative regulation of glycogen (starch) synthase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] +synonym: "negative regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] +synonym: "negative regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "negative regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity + +[Term] +id: GO:2000467 +name: positive regulation of glycogen (starch) synthase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol] +synonym: "positive regulation of glycogen (starch) synthetase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDP-glucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDP-glycogen synthase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDPG-glycogen synthetase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDPG-glycogen transglucosylase activity" EXACT [GOC:obol] +synonym: "positive regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [GOC:obol] +synonym: "positive regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [GOC:obol] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:2000465 ! regulation of glycogen (starch) synthase activity + +[Term] +id: GO:2000468 +name: regulation of peroxidase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peroxidase activity." [GOC:obol] +synonym: "regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] +synonym: "regulation of oxyperoxidase activity" EXACT [GOC:obol] +synonym: "regulation of peroxidase reaction" EXACT [GOC:obol] +is_a: GO:0051341 ! regulation of oxidoreductase activity + +[Term] +id: GO:2000469 +name: negative regulation of peroxidase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol] +synonym: "negative regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] +synonym: "negative regulation of oxyperoxidase activity" EXACT [GOC:obol] +synonym: "negative regulation of peroxidase reaction" EXACT [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051354 ! negative regulation of oxidoreductase activity +is_a: GO:2000468 ! regulation of peroxidase activity + +[Term] +id: GO:2000470 +name: positive regulation of peroxidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol] +synonym: "positive regulation of donor:hydrogen-peroxide oxidoreductase activity" EXACT [GOC:obol] +synonym: "positive regulation of oxyperoxidase activity" EXACT [GOC:obol] +synonym: "positive regulation of peroxidase reaction" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051353 ! positive regulation of oxidoreductase activity +is_a: GO:2000468 ! regulation of peroxidase activity + +[Term] +id: GO:2000471 +name: regulation of hematopoietic stem cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] +synonym: "regulation of hemopoietic stem cell migration" EXACT [GOC:obol] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0035701 ! hematopoietic stem cell migration + +[Term] +id: GO:2000472 +name: negative regulation of hematopoietic stem cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] +synonym: "negative regulation of hemopoietic stem cell migration" EXACT [GOC:obol] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:2000471 ! regulation of hematopoietic stem cell migration +relationship: negatively_regulates GO:0035701 ! hematopoietic stem cell migration + +[Term] +id: GO:2000473 +name: positive regulation of hematopoietic stem cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol] +synonym: "positive regulation of hemopoietic stem cell migration" EXACT [GOC:obol] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:2000471 ! regulation of hematopoietic stem cell migration +relationship: positively_regulates GO:0035701 ! hematopoietic stem cell migration + +[Term] +id: GO:2000474 +name: regulation of opioid receptor signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] +synonym: "regulation of opioid receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway +relationship: regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway + +[Term] +id: GO:2000475 +name: negative regulation of opioid receptor signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] +synonym: "negative regulation of opioid receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway +is_a: GO:2000474 ! regulation of opioid receptor signaling pathway +relationship: negatively_regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway + +[Term] +id: GO:2000476 +name: positive regulation of opioid receptor signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol] +synonym: "positive regulation of opioid receptor signalling pathway" EXACT [GOC:mah] +is_a: GO:0045745 ! positive regulation of G protein-coupled receptor signaling pathway +is_a: GO:2000474 ! regulation of opioid receptor signaling pathway +relationship: positively_regulates GO:0038003 ! G protein-coupled opioid receptor signaling pathway + +[Term] +id: GO:2000477 +name: regulation of metanephric glomerular visceral epithelial cell development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] +synonym: "regulation of metanephric podocyte development" RELATED [GOC:obol] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development + +[Term] +id: GO:2000478 +name: positive regulation of metanephric glomerular visceral epithelial cell development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol] +synonym: "positive regulation of metanephric podocyte development" RELATED [GOC:obol] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:2000477 ! regulation of metanephric glomerular visceral epithelial cell development +relationship: positively_regulates GO:0072249 ! metanephric glomerular visceral epithelial cell development + +[Term] +id: GO:2000479 +name: regulation of cAMP-dependent protein kinase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] +synonym: "regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "regulation of AMPK" RELATED [GOC:obol] +synonym: "regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] +synonym: "regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] +synonym: "regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "regulation of PKA" RELATED [GOC:obol] +synonym: "regulation of PKA C" RELATED [GOC:obol] +synonym: "regulation of protein kinase A activity" RELATED [GOC:obol] +synonym: "regulation of STK22" RELATED [GOC:obol] +is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity + +[Term] +id: GO:2000480 +name: negative regulation of cAMP-dependent protein kinase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] +synonym: "negative regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "negative regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "negative regulation of AMPK" RELATED [GOC:obol] +synonym: "negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] +synonym: "negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] +synonym: "negative regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "negative regulation of PKA" RELATED [GOC:obol] +synonym: "negative regulation of PKA C" RELATED [GOC:obol] +synonym: "negative regulation of protein kinase A activity" RELATED [GOC:obol] +synonym: "negative regulation of STK22" RELATED [GOC:obol] +is_a: GO:0071901 ! negative regulation of protein serine/threonine kinase activity +is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity + +[Term] +id: GO:2000481 +name: positive regulation of cAMP-dependent protein kinase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol] +synonym: "positive regulation of 3',5' cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "positive regulation of 3',5'-cAMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "positive regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "positive regulation of AMPK" RELATED [GOC:obol] +synonym: "positive regulation of ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [GOC:obol] +synonym: "positive regulation of cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [GOC:obol] +synonym: "positive regulation of cyclic AMP-dependent protein kinase activity" EXACT [GOC:obol] +synonym: "positive regulation of PKA" RELATED [GOC:obol] +synonym: "positive regulation of PKA C" RELATED [GOC:obol] +synonym: "positive regulation of protein kinase A activity" RELATED [GOC:obol] +synonym: "positive regulation of STK22" RELATED [GOC:obol] +is_a: GO:0071902 ! positive regulation of protein serine/threonine kinase activity +is_a: GO:2000479 ! regulation of cAMP-dependent protein kinase activity + +[Term] +id: GO:2000485 +name: regulation of glutamine transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glutamine transport." [GOC:obol] +synonym: "regulation of L-glutamine transport" RELATED [GOC:obol] +is_a: GO:0044070 ! regulation of anion transport +is_a: GO:0051955 ! regulation of amino acid transport +relationship: regulates GO:0006868 ! glutamine transport + +[Term] +id: GO:2000486 +name: negative regulation of glutamine transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol] +synonym: "negative regulation of L-glutamine transport" RELATED [GOC:obol] +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:2000485 ! regulation of glutamine transport +relationship: negatively_regulates GO:0006868 ! glutamine transport + +[Term] +id: GO:2000487 +name: positive regulation of glutamine transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol] +synonym: "positive regulation of L-glutamine transport" RELATED [GOC:obol] +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1903793 ! positive regulation of anion transport +is_a: GO:2000485 ! regulation of glutamine transport +relationship: positively_regulates GO:0006868 ! glutamine transport + +[Term] +id: GO:2000488 +name: positive regulation of brassinosteroid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol] +synonym: "positive regulation of brassinosteroid anabolism" EXACT [GOC:obol] +synonym: "positive regulation of brassinosteroid biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of brassinosteroid formation" EXACT [GOC:obol] +synonym: "positive regulation of brassinosteroid synthesis" EXACT [GOC:obol] +is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process +is_a: GO:0010893 ! positive regulation of steroid biosynthetic process +is_a: GO:0046886 ! positive regulation of hormone biosynthetic process +relationship: positively_regulates GO:0016132 ! brassinosteroid biosynthetic process + +[Term] +id: GO:2000489 +name: regulation of hepatic stellate cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] +is_a: GO:0050865 ! regulation of cell activation +relationship: regulates GO:0035733 ! hepatic stellate cell activation + +[Term] +id: GO:2000490 +name: negative regulation of hepatic stellate cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] +is_a: GO:0050866 ! negative regulation of cell activation +is_a: GO:2000489 ! regulation of hepatic stellate cell activation +relationship: negatively_regulates GO:0035733 ! hepatic stellate cell activation + +[Term] +id: GO:2000491 +name: positive regulation of hepatic stellate cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol] +is_a: GO:0050867 ! positive regulation of cell activation +is_a: GO:2000489 ! regulation of hepatic stellate cell activation +relationship: positively_regulates GO:0035733 ! hepatic stellate cell activation + +[Term] +id: GO:2000492 +name: regulation of interleukin-18-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] +synonym: "regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0035655 ! interleukin-18-mediated signaling pathway + +[Term] +id: GO:2000493 +name: negative regulation of interleukin-18-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] +synonym: "negative regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway +relationship: negatively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway + +[Term] +id: GO:2000494 +name: positive regulation of interleukin-18-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol] +synonym: "positive regulation of interleukin-18-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:2000492 ! regulation of interleukin-18-mediated signaling pathway +relationship: positively_regulates GO:0035655 ! interleukin-18-mediated signaling pathway + +[Term] +id: GO:2000495 +name: regulation of cell proliferation involved in compound eye morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] +is_a: GO:0042127 ! regulation of cell population proliferation +relationship: regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis + +[Term] +id: GO:2000496 +name: negative regulation of cell proliferation involved in compound eye morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis +relationship: negatively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis + +[Term] +id: GO:2000497 +name: positive regulation of cell proliferation involved in compound eye morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:2000495 ! regulation of cell proliferation involved in compound eye morphogenesis +relationship: positively_regulates GO:0035736 ! cell proliferation involved in compound eye morphogenesis + +[Term] +id: GO:2000498 +name: obsolete regulation of induction of apoptosis in response to chemical stimulus +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] +comment: This term was made obsolete because it is ill-defined. +synonym: "regulation of induction of apoptosis in response to chemical stimulus" EXACT [] +synonym: "regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000499 +name: obsolete negative regulation of induction of apoptosis in response to chemical stimulus +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] +comment: This term was made obsolete because it is ill-defined. +synonym: "negative regulation of induction of apoptosis in response to chemical stimulus" EXACT [] +synonym: "negative regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000500 +name: obsolete positive regulation of induction of apoptosis in response to chemical stimulus +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol] +comment: This term was made obsolete because it is ill-defined. +synonym: "positive regulation of induction of apoptosis in response to chemical stimulus" EXACT [] +synonym: "positive regulation of induction of apoptosis in response to chemical substance" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000501 +name: regulation of natural killer cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] +is_a: GO:1901623 ! regulation of lymphocyte chemotaxis +relationship: regulates GO:0035747 ! natural killer cell chemotaxis + +[Term] +id: GO:2000502 +name: negative regulation of natural killer cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] +is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis +is_a: GO:2000501 ! regulation of natural killer cell chemotaxis +relationship: negatively_regulates GO:0035747 ! natural killer cell chemotaxis + +[Term] +id: GO:2000503 +name: positive regulation of natural killer cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF] +is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis +is_a: GO:2000501 ! regulation of natural killer cell chemotaxis +relationship: positively_regulates GO:0035747 ! natural killer cell chemotaxis + +[Term] +id: GO:2000504 +name: positive regulation of blood vessel remodeling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol] +is_a: GO:0034105 ! positive regulation of tissue remodeling +is_a: GO:0060312 ! regulation of blood vessel remodeling +relationship: positively_regulates GO:0001974 ! blood vessel remodeling + +[Term] +id: GO:2000508 +name: regulation of dendritic cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] +is_a: GO:0002688 ! regulation of leukocyte chemotaxis +is_a: GO:0071675 ! regulation of mononuclear cell migration +relationship: regulates GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:2000509 +name: negative regulation of dendritic cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] +is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis +is_a: GO:0071676 ! negative regulation of mononuclear cell migration +is_a: GO:2000508 ! regulation of dendritic cell chemotaxis +relationship: negatively_regulates GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:2000510 +name: positive regulation of dendritic cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol] +is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis +is_a: GO:0071677 ! positive regulation of mononuclear cell migration +is_a: GO:2000508 ! regulation of dendritic cell chemotaxis +relationship: positively_regulates GO:0002407 ! dendritic cell chemotaxis + +[Term] +id: GO:2000511 +name: regulation of granzyme A production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of granzyme A production." [GOC:obol] +is_a: GO:0002700 ! regulation of production of molecular mediator of immune response +relationship: regulates GO:0035746 ! granzyme A production + +[Term] +id: GO:2000512 +name: negative regulation of granzyme A production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol] +is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response +is_a: GO:2000511 ! regulation of granzyme A production +relationship: negatively_regulates GO:0035746 ! granzyme A production + +[Term] +id: GO:2000513 +name: positive regulation of granzyme A production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol] +is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response +is_a: GO:2000511 ! regulation of granzyme A production +relationship: positively_regulates GO:0035746 ! granzyme A production + +[Term] +id: GO:2000514 +name: regulation of CD4-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:2000515 +name: negative regulation of CD4-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: negatively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:2000516 +name: positive regulation of CD4-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: positively_regulates GO:0035710 ! CD4-positive, alpha-beta T cell activation + +[Term] +id: GO:2000517 +name: regulation of T-helper 1 cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] +synonym: "regulation of Th1 cell activation" EXACT [GOC:obol] +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: regulates GO:0035711 ! T-helper 1 cell activation + +[Term] +id: GO:2000518 +name: negative regulation of T-helper 1 cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] +synonym: "negative regulation of Th1 cell activation" EXACT [GOC:obol] +is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000517 ! regulation of T-helper 1 cell activation +relationship: negatively_regulates GO:0035711 ! T-helper 1 cell activation + +[Term] +id: GO:2000519 +name: positive regulation of T-helper 1 cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol] +synonym: "positive regulation of Th1 cell activation" EXACT [GOC:obol] +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000517 ! regulation of T-helper 1 cell activation +relationship: positively_regulates GO:0035711 ! T-helper 1 cell activation + +[Term] +id: GO:2000520 +name: regulation of immunological synapse formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol] +synonym: "regulation of formation of immunological synapse" EXACT [GOC:obol] +is_a: GO:0051249 ! regulation of lymphocyte activation +relationship: regulates GO:0001771 ! immunological synapse formation + +[Term] +id: GO:2000521 +name: negative regulation of immunological synapse formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol] +synonym: "negative regulation of formation of immunological synapse" EXACT [GOC:obol] +is_a: GO:0051250 ! negative regulation of lymphocyte activation +is_a: GO:2000520 ! regulation of immunological synapse formation +relationship: negatively_regulates GO:0001771 ! immunological synapse formation + +[Term] +id: GO:2000522 +name: positive regulation of immunological synapse formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol] +synonym: "positive regulation of formation of immunological synapse" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:2000520 ! regulation of immunological synapse formation +relationship: positively_regulates GO:0001771 ! immunological synapse formation + +[Term] +id: GO:2000523 +name: regulation of T cell costimulation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell costimulation." [GOC:obol] +synonym: "regulation of T cell co-stimulation" EXACT [GOC:obol] +synonym: "regulation of T lymphocyte costimulation" EXACT [GOC:obol] +synonym: "regulation of T-cell co-stimulation" EXACT [GOC:obol] +synonym: "regulation of T-cell costimulation" EXACT [GOC:obol] +synonym: "regulation of T-lymphocyte costimulation" EXACT [GOC:obol] +is_a: GO:0050863 ! regulation of T cell activation +is_a: GO:1903037 ! regulation of leukocyte cell-cell adhesion +relationship: regulates GO:0031295 ! T cell costimulation + +[Term] +id: GO:2000524 +name: negative regulation of T cell costimulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol] +synonym: "negative regulation of T cell co-stimulation" EXACT [GOC:obol] +synonym: "negative regulation of T lymphocyte costimulation" EXACT [GOC:obol] +synonym: "negative regulation of T-cell co-stimulation" EXACT [GOC:obol] +synonym: "negative regulation of T-cell costimulation" EXACT [GOC:obol] +synonym: "negative regulation of T-lymphocyte costimulation" EXACT [GOC:obol] +is_a: GO:0002683 ! negative regulation of immune system process +is_a: GO:2000523 ! regulation of T cell costimulation +relationship: negatively_regulates GO:0031295 ! T cell costimulation + +[Term] +id: GO:2000525 +name: positive regulation of T cell costimulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol] +synonym: "positive regulation of T cell co-stimulation" EXACT [GOC:obol] +synonym: "positive regulation of T lymphocyte costimulation" EXACT [GOC:obol] +synonym: "positive regulation of T-cell co-stimulation" EXACT [GOC:obol] +synonym: "positive regulation of T-cell costimulation" EXACT [GOC:obol] +synonym: "positive regulation of T-lymphocyte costimulation" EXACT [GOC:obol] +is_a: GO:0050870 ! positive regulation of T cell activation +is_a: GO:2000523 ! regulation of T cell costimulation +relationship: positively_regulates GO:0031295 ! T cell costimulation + +[Term] +id: GO:2000526 +name: positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation +namespace: biological_process +def: "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol] +synonym: "positive regulation of glycoprotein biosynthetic process of formation of immunological synapse" EXACT [GOC:obol] +synonym: "positive regulation of glycoprotein biosynthetic process of immunological synapse formation" EXACT [GOC:obol] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +relationship: part_of GO:0001771 ! immunological synapse formation + +[Term] +id: GO:2000527 +name: regulation of myeloid dendritic cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] +is_a: GO:2000508 ! regulation of dendritic cell chemotaxis +relationship: regulates GO:0002408 ! myeloid dendritic cell chemotaxis + +[Term] +id: GO:2000528 +name: negative regulation of myeloid dendritic cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] +is_a: GO:2000509 ! negative regulation of dendritic cell chemotaxis +is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis +relationship: negatively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis + +[Term] +id: GO:2000529 +name: positive regulation of myeloid dendritic cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol] +is_a: GO:2000510 ! positive regulation of dendritic cell chemotaxis +is_a: GO:2000527 ! regulation of myeloid dendritic cell chemotaxis +relationship: positively_regulates GO:0002408 ! myeloid dendritic cell chemotaxis + +[Term] +id: GO:2000530 +name: obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol] +synonym: "positive regulation of regulation of insulin secretion in response to glucose" EXACT [GOC:obol] +synonym: "positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus" EXACT [] +is_obsolete: true + +[Term] +id: GO:2000531 +name: obsolete regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:vw] +comment: This term was obsoleted because it represents a GO-CAM model. +is_obsolete: true + +[Term] +id: GO:2000532 +name: regulation of renal albumin absorption +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0097018 ! renal albumin absorption + +[Term] +id: GO:2000533 +name: negative regulation of renal albumin absorption +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000532 ! regulation of renal albumin absorption +relationship: negatively_regulates GO:0097018 ! renal albumin absorption + +[Term] +id: GO:2000534 +name: positive regulation of renal albumin absorption +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf] +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000532 ! regulation of renal albumin absorption +relationship: positively_regulates GO:0097018 ! renal albumin absorption + +[Term] +id: GO:2000535 +name: regulation of entry of bacterium into host cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] +synonym: "regulation of bacterial entry into host cell" EXACT [GOC:obol] +synonym: "regulation of invasion of bacteria into host cell" EXACT [GOC:obol] +is_a: GO:0052372 ! modulation by symbiont of entry into host +relationship: regulates GO:0035635 ! entry of bacterium into host cell + +[Term] +id: GO:2000536 +name: negative regulation of entry of bacterium into host cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol] +synonym: "negative regulation of bacterial entry into host cell" EXACT [GOC:obol] +synonym: "negative regulation of invasion of bacteria into host cell" EXACT [GOC:obol] +is_a: GO:0048519 ! negative regulation of biological process +is_a: GO:2000535 ! regulation of entry of bacterium into host cell +relationship: negatively_regulates GO:0035635 ! entry of bacterium into host cell + +[Term] +id: GO:2000537 +name: regulation of B cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of B cell chemotaxis." [GOC:obol] +is_a: GO:1901623 ! regulation of lymphocyte chemotaxis +relationship: regulates GO:0035754 ! B cell chemotaxis + +[Term] +id: GO:2000538 +name: positive regulation of B cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol] +is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis +is_a: GO:2000537 ! regulation of B cell chemotaxis +relationship: positively_regulates GO:0035754 ! B cell chemotaxis + +[Term] +id: GO:2000539 +name: regulation of protein geranylgeranylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] +synonym: "regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] +synonym: "regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] +is_a: GO:0031399 ! regulation of protein modification process +is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process +relationship: regulates GO:0018344 ! protein geranylgeranylation + +[Term] +id: GO:2000540 +name: negative regulation of protein geranylgeranylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] +synonym: "negative regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] +synonym: "negative regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] +is_a: GO:0031400 ! negative regulation of protein modification process +is_a: GO:2000539 ! regulation of protein geranylgeranylation +relationship: negatively_regulates GO:0018344 ! protein geranylgeranylation + +[Term] +id: GO:2000541 +name: positive regulation of protein geranylgeranylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol] +synonym: "positive regulation of C-terminal protein geranylgeranylation" RELATED [GOC:obol] +synonym: "positive regulation of protein amino acid geranylgeranylation" EXACT [GOC:obol] +is_a: GO:0031401 ! positive regulation of protein modification process +is_a: GO:2000539 ! regulation of protein geranylgeranylation +relationship: positively_regulates GO:0018344 ! protein geranylgeranylation + +[Term] +id: GO:2000542 +name: negative regulation of gastrulation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol] +is_a: GO:0010470 ! regulation of gastrulation +is_a: GO:0045992 ! negative regulation of embryonic development +relationship: negatively_regulates GO:0007369 ! gastrulation + +[Term] +id: GO:2000543 +name: positive regulation of gastrulation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gastrulation." [GOC:obol] +is_a: GO:0010470 ! regulation of gastrulation +is_a: GO:0040019 ! positive regulation of embryonic development +relationship: positively_regulates GO:0007369 ! gastrulation + +[Term] +id: GO:2000544 +name: regulation of endothelial cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] +is_a: GO:1904847 ! regulation of cell chemotaxis to fibroblast growth factor +is_a: GO:2001026 ! regulation of endothelial cell chemotaxis +relationship: regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:2000545 +name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] +is_a: GO:1904848 ! negative regulation of cell chemotaxis to fibroblast growth factor +is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor +is_a: GO:2001027 ! negative regulation of endothelial cell chemotaxis +relationship: negatively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:2000546 +name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol] +is_a: GO:1904849 ! positive regulation of cell chemotaxis to fibroblast growth factor +is_a: GO:2000544 ! regulation of endothelial cell chemotaxis to fibroblast growth factor +is_a: GO:2001028 ! positive regulation of endothelial cell chemotaxis +relationship: positively_regulates GO:0035768 ! endothelial cell chemotaxis to fibroblast growth factor + +[Term] +id: GO:2000547 +name: regulation of dendritic cell dendrite assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] +synonym: "regulation of dendritic extension" RELATED [GOC:obol] +is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly +relationship: regulates GO:0097026 ! dendritic cell dendrite assembly + +[Term] +id: GO:2000548 +name: negative regulation of dendritic cell dendrite assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] +synonym: "negative regulation of dendritic extension" RELATED [GOC:obol] +is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly +is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly +relationship: negatively_regulates GO:0097026 ! dendritic cell dendrite assembly + +[Term] +id: GO:2000549 +name: positive regulation of dendritic cell dendrite assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol] +synonym: "positive regulation of dendritic extension" RELATED [GOC:obol] +is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly +is_a: GO:2000547 ! regulation of dendritic cell dendrite assembly +relationship: positively_regulates GO:0097026 ! dendritic cell dendrite assembly + +[Term] +id: GO:2000550 +name: negative regulation of B cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol] +is_a: GO:1901624 ! negative regulation of lymphocyte chemotaxis +is_a: GO:2000537 ! regulation of B cell chemotaxis +relationship: negatively_regulates GO:0035754 ! B cell chemotaxis + +[Term] +id: GO:2000551 +name: regulation of T-helper 2 cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] +synonym: "regulation of Th2 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002724 ! regulation of T cell cytokine production +is_a: GO:0002828 ! regulation of type 2 immune response +relationship: regulates GO:0035745 ! T-helper 2 cell cytokine production + +[Term] +id: GO:2000552 +name: negative regulation of T-helper 2 cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] +synonym: "negative regulation of Th2 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002725 ! negative regulation of T cell cytokine production +is_a: GO:0002829 ! negative regulation of type 2 immune response +is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production +relationship: negatively_regulates GO:0035745 ! T-helper 2 cell cytokine production + +[Term] +id: GO:2000553 +name: positive regulation of T-helper 2 cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol] +synonym: "positive regulation of Th2 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002726 ! positive regulation of T cell cytokine production +is_a: GO:0002830 ! positive regulation of type 2 immune response +is_a: GO:2000551 ! regulation of T-helper 2 cell cytokine production +relationship: positively_regulates GO:0035745 ! T-helper 2 cell cytokine production + +[Term] +id: GO:2000554 +name: regulation of T-helper 1 cell cytokine production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] +synonym: "regulation of Th1 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002724 ! regulation of T cell cytokine production +is_a: GO:0002825 ! regulation of T-helper 1 type immune response +relationship: regulates GO:0035744 ! T-helper 1 cell cytokine production + +[Term] +id: GO:2000555 +name: negative regulation of T-helper 1 cell cytokine production +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] +synonym: "negative regulation of Th1 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002725 ! negative regulation of T cell cytokine production +is_a: GO:0002826 ! negative regulation of T-helper 1 type immune response +is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production +relationship: negatively_regulates GO:0035744 ! T-helper 1 cell cytokine production + +[Term] +id: GO:2000556 +name: positive regulation of T-helper 1 cell cytokine production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol] +synonym: "positive regulation of Th1 cell cytokine production" EXACT [GOC:obol] +is_a: GO:0002726 ! positive regulation of T cell cytokine production +is_a: GO:0002827 ! positive regulation of T-helper 1 type immune response +is_a: GO:2000554 ! regulation of T-helper 1 cell cytokine production +relationship: positively_regulates GO:0035744 ! T-helper 1 cell cytokine production + +[Term] +id: GO:2000557 +name: regulation of immunoglobulin production in mucosal tissue +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] +synonym: "regulation of antibody production in mucosal tissue" EXACT [GOC:obol] +is_a: GO:0002637 ! regulation of immunoglobulin production +is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response +relationship: regulates GO:0002426 ! immunoglobulin production in mucosal tissue + +[Term] +id: GO:2000558 +name: positive regulation of immunoglobulin production in mucosal tissue +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol] +synonym: "positive regulation of antibody production in mucosal tissue" EXACT [GOC:obol] +is_a: GO:0002639 ! positive regulation of immunoglobulin production +is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response +is_a: GO:2000557 ! regulation of immunoglobulin production in mucosal tissue +relationship: positively_regulates GO:0002426 ! immunoglobulin production in mucosal tissue + +[Term] +id: GO:2000559 +name: regulation of CD24 production +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] +synonym: "regulation of CD24 anabolism" EXACT [GOC:obol] +synonym: "regulation of CD24 biosynthesis" EXACT [GOC:obol] +synonym: "regulation of CD24 biosynthetic process" EXACT [] +synonym: "regulation of CD24 formation" EXACT [GOC:obol] +synonym: "regulation of CD24 synthesis" EXACT [GOC:obol] +is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process +relationship: regulates GO:0035724 ! CD24 biosynthetic process + +[Term] +id: GO:2000560 +name: positive regulation of CD24 production +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol] +synonym: "positive regulation of CD24 anabolism" EXACT [GOC:obol] +synonym: "positive regulation of CD24 biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of CD24 biosynthetic process" EXACT [] +synonym: "positive regulation of CD24 formation" EXACT [GOC:obol] +synonym: "positive regulation of CD24 synthesis" EXACT [GOC:obol] +is_a: GO:0010560 ! positive regulation of glycoprotein biosynthetic process +is_a: GO:2000559 ! regulation of CD24 production +relationship: positively_regulates GO:0035724 ! CD24 biosynthetic process + +[Term] +id: GO:2000561 +name: regulation of CD4-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000562 +name: negative regulation of CD4-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation +is_a: GO:2000515 ! negative regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation +relationship: negatively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000563 +name: positive regulation of CD4-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000561 ! regulation of CD4-positive, alpha-beta T cell proliferation +relationship: positively_regulates GO:0035739 ! CD4-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000564 +name: regulation of CD8-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046640 ! regulation of alpha-beta T cell proliferation +is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation +relationship: regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000565 +name: negative regulation of CD8-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046642 ! negative regulation of alpha-beta T cell proliferation +is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation +is_a: GO:2001186 ! negative regulation of CD8-positive, alpha-beta T cell activation +relationship: negatively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000566 +name: positive regulation of CD8-positive, alpha-beta T cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol] +is_a: GO:0046641 ! positive regulation of alpha-beta T cell proliferation +is_a: GO:2000564 ! regulation of CD8-positive, alpha-beta T cell proliferation +is_a: GO:2001187 ! positive regulation of CD8-positive, alpha-beta T cell activation +relationship: positively_regulates GO:0035740 ! CD8-positive, alpha-beta T cell proliferation + +[Term] +id: GO:2000567 +name: regulation of memory T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of memory T cell activation." [GOC:obol] +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0035709 ! memory T cell activation + +[Term] +id: GO:2000568 +name: positive regulation of memory T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol] +is_a: GO:0050870 ! positive regulation of T cell activation +is_a: GO:2000567 ! regulation of memory T cell activation +relationship: positively_regulates GO:0035709 ! memory T cell activation + +[Term] +id: GO:2000569 +name: regulation of T-helper 2 cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] +synonym: "regulation of Th2 cell activation" EXACT [GOC:obol] +is_a: GO:2000514 ! regulation of CD4-positive, alpha-beta T cell activation +relationship: regulates GO:0035712 ! T-helper 2 cell activation + +[Term] +id: GO:2000570 +name: positive regulation of T-helper 2 cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol] +synonym: "positive regulation of Th2 cell activation" EXACT [GOC:obol] +is_a: GO:2000516 ! positive regulation of CD4-positive, alpha-beta T cell activation +is_a: GO:2000569 ! regulation of T-helper 2 cell activation +relationship: positively_regulates GO:0035712 ! T-helper 2 cell activation + +[Term] +id: GO:2000571 +name: regulation of interleukin-4-dependent isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] +synonym: "regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] +is_a: GO:0048293 ! regulation of isotype switching to IgE isotypes +relationship: regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes + +[Term] +id: GO:2000572 +name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol] +synonym: "positive regulation of IL-4-dependent isotype switching to IgE isotypes" EXACT [GOC:obol] +is_a: GO:0048295 ! positive regulation of isotype switching to IgE isotypes +is_a: GO:2000571 ! regulation of interleukin-4-dependent isotype switching to IgE isotypes +relationship: positively_regulates GO:0035708 ! interleukin-4-dependent isotype switching to IgE isotypes + +[Term] +id: GO:2000573 +name: positive regulation of DNA biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] +synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] +synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of DNA formation" EXACT [GOC:obol] +synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:0051054 ! positive regulation of DNA metabolic process +is_a: GO:2000278 ! regulation of DNA biosynthetic process +relationship: positively_regulates GO:0071897 ! DNA biosynthetic process + +[Term] +id: GO:2000574 +name: obsolete regulation of microtubule motor activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of microtubule motor activity." [GOC:kmv] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of axonemal motor activity" RELATED [GOC:obol] +synonym: "regulation of dynein" RELATED [GOC:obol] +synonym: "regulation of dynein ATPase activity" RELATED [GOC:obol] +synonym: "regulation of kinesin" RELATED [GOC:obol] +synonym: "regulation of kinesin motor activity" RELATED [GOC:obol] +synonym: "regulation of kinetochore motor activity" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:2000575 +name: obsolete negative regulation of microtubule motor activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv] +comment: This term was obsoleted because it represents a molecular function. +synonym: "negative regulation of axonemal motor activity" RELATED [GOC:obol] +synonym: "negative regulation of dynein" RELATED [GOC:obol] +synonym: "negative regulation of dynein ATPase activity" RELATED [GOC:obol] +synonym: "negative regulation of kinesin" RELATED [GOC:obol] +synonym: "negative regulation of kinesin motor activity" RELATED [GOC:obol] +synonym: "negative regulation of kinetochore motor activity" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0140661 + +[Term] +id: GO:2000576 +name: obsolete positive regulation of microtubule motor activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv] +comment: This term was obsoleted because it represents a molecular function. +synonym: "positive regulation of axonemal motor activity" RELATED [GOC:obol] +synonym: "positive regulation of dynein" RELATED [GOC:obol] +synonym: "positive regulation of dynein ATPase activity" RELATED [GOC:obol] +synonym: "positive regulation of kinesin" RELATED [GOC:obol] +synonym: "positive regulation of kinesin motor activity" RELATED [GOC:obol] +synonym: "positive regulation of kinetochore motor activity" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0140660 + +[Term] +id: GO:2000577 +name: obsolete regulation of microtubule motor activity, minus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT [] +synonym: "regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] +synonym: "regulation of minus-end-directed kinesin ATPase activity" RELATED [GOC:obol] +synonym: "regulation of minus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:2000578 +name: obsolete negative regulation of microtubule motor activity, minus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "negative regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT [] +synonym: "negative regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] +synonym: "negative regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol] +synonym: "negative regulation of minus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140661 + +[Term] +id: GO:2000579 +name: obsolete positive regulation of microtubule motor activity, minus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "positive regulation of ATP-dependent microtubule motor activity, minus-end-directed" EXACT [] +synonym: "positive regulation of kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [GOC:obol] +synonym: "positive regulation of minus-end-directed kinesin ATPase activity" EXACT [GOC:obol] +synonym: "positive regulation of minus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140660 + +[Term] +id: GO:2000580 +name: obsolete regulation of microtubule motor activity, plus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT [] +synonym: "regulation of kinesin activity" RELATED [GOC:obol] +synonym: "regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] +synonym: "regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] +synonym: "regulation of plus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140659 + +[Term] +id: GO:2000581 +name: obsolete negative regulation of microtubule motor activity, plus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "negative regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT [] +synonym: "negative regulation of kinesin activity" RELATED [GOC:obol] +synonym: "negative regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] +synonym: "negative regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] +synonym: "negative regulation of plus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140661 + +[Term] +id: GO:2000582 +name: obsolete positive regulation of microtubule motor activity, plus-end-directed +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw] +comment: This term was obsoleted because it represents a molecular function. +synonym: "positive regulation of ATP-dependent microtubule motor activity, plus-end-directed" EXACT [] +synonym: "positive regulation of kinesin activity" RELATED [GOC:obol] +synonym: "positive regulation of kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [GOC:obol] +synonym: "positive regulation of plus-end-directed kinesin ATPase activity" EXACT [GOC:obol] +synonym: "positive regulation of plus-end-directed microtubule motor activity" BROAD [] +is_obsolete: true +consider: GO:0140660 + +[Term] +id: GO:2000583 +name: regulation of platelet-derived growth factor receptor-alpha signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] +synonym: "regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] +synonym: "regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] +synonym: "regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway + +[Term] +id: GO:2000584 +name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol, GOC:yaf] +synonym: "negative regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] +is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway +is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway +relationship: negatively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway + +[Term] +id: GO:2000585 +name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol] +synonym: "positive regulation of alphaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of PDGF receptor-alpha signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of PDGFR-alpha signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of platelet-derived growth factor receptor-alpha signalling pathway" EXACT [GOC:mah] +is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway +is_a: GO:2000583 ! regulation of platelet-derived growth factor receptor-alpha signaling pathway +relationship: positively_regulates GO:0035790 ! platelet-derived growth factor receptor-alpha signaling pathway + +[Term] +id: GO:2000586 +name: regulation of platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] +synonym: "regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] +synonym: "regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] +synonym: "regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway +relationship: regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway + +[Term] +id: GO:2000587 +name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] +synonym: "negative regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +is_a: GO:0010642 ! negative regulation of platelet-derived growth factor receptor signaling pathway +is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway +relationship: negatively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway + +[Term] +id: GO:2000588 +name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol] +synonym: "positive regulation of betaPDGF receptor signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of PDGF receptor-beta signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of PDGFR-beta signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of platelet-derived growth factor receptor-beta signalling pathway" EXACT [GOC:mah] +is_a: GO:0010641 ! positive regulation of platelet-derived growth factor receptor signaling pathway +is_a: GO:2000586 ! regulation of platelet-derived growth factor receptor-beta signaling pathway +relationship: positively_regulates GO:0035791 ! platelet-derived growth factor receptor-beta signaling pathway + +[Term] +id: GO:2000589 +name: regulation of metanephric mesenchymal cell migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] +synonym: "regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0035789 ! metanephric mesenchymal cell migration + +[Term] +id: GO:2000590 +name: negative regulation of metanephric mesenchymal cell migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol] +synonym: "negative regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0072217 ! negative regulation of metanephros development +is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration +relationship: negatively_regulates GO:0035789 ! metanephric mesenchymal cell migration + +[Term] +id: GO:2000591 +name: positive regulation of metanephric mesenchymal cell migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "positive regulation of metanephric mesenchyme chemotaxis" RELATED [GOC:obol] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:2000589 ! regulation of metanephric mesenchymal cell migration +relationship: positively_regulates GO:0035789 ! metanephric mesenchymal cell migration + +[Term] +id: GO:2000592 +name: regulation of metanephric DCT cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] +synonym: "regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0072240 ! metanephric DCT cell differentiation + +[Term] +id: GO:2000593 +name: negative regulation of metanephric DCT cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] +synonym: "negative regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation +relationship: negatively_regulates GO:0072240 ! metanephric DCT cell differentiation + +[Term] +id: GO:2000594 +name: positive regulation of metanephric DCT cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol] +synonym: "positive regulation of metanephric distal convoluted tubule cell differentiation" EXACT [GOC:obol] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:2000592 ! regulation of metanephric DCT cell differentiation +relationship: positively_regulates GO:0072240 ! metanephric DCT cell differentiation + +[Term] +id: GO:2000595 +name: regulation of optic nerve formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of optic nerve formation." [GOC:obol] +synonym: "regulation of CN II biosynthesis" RELATED [GOC:obol] +synonym: "regulation of CN II formation" RELATED [GOC:obol] +is_a: GO:0022603 ! regulation of anatomical structure morphogenesis +relationship: regulates GO:0021634 ! optic nerve formation + +[Term] +id: GO:2000596 +name: negative regulation of optic nerve formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol] +synonym: "negative regulation of CN II biosynthesis" RELATED [GOC:obol] +synonym: "negative regulation of CN II formation" RELATED [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000595 ! regulation of optic nerve formation +relationship: negatively_regulates GO:0021634 ! optic nerve formation + +[Term] +id: GO:2000597 +name: positive regulation of optic nerve formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol] +synonym: "positive regulation of CN II biosynthesis" RELATED [GOC:obol] +synonym: "positive regulation of CN II formation" RELATED [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000595 ! regulation of optic nerve formation +relationship: positively_regulates GO:0021634 ! optic nerve formation + +[Term] +id: GO:2000601 +name: positive regulation of Arp2/3 complex-mediated actin nucleation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476] +synonym: "positive regulation of actin filament branch nucleation" EXACT [GOC:obol] +synonym: "positive regulation of branched actin filament nucleation" EXACT [GOC:obol] +is_a: GO:0034315 ! regulation of Arp2/3 complex-mediated actin nucleation +is_a: GO:0051127 ! positive regulation of actin nucleation +relationship: positively_regulates GO:0034314 ! Arp2/3 complex-mediated actin nucleation + +[Term] +id: GO:2000602 +name: obsolete regulation of interphase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol] +comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. +synonym: "regulation of interphase of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:2000603 +name: regulation of secondary growth +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary growth." [GOC:obol] +is_a: GO:0040008 ! regulation of growth +relationship: regulates GO:0080117 ! secondary growth + +[Term] +id: GO:2000604 +name: negative regulation of secondary growth +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol] +is_a: GO:0045926 ! negative regulation of growth +is_a: GO:2000603 ! regulation of secondary growth +relationship: negatively_regulates GO:0080117 ! secondary growth + +[Term] +id: GO:2000605 +name: positive regulation of secondary growth +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol] +is_a: GO:0045927 ! positive regulation of growth +is_a: GO:2000603 ! regulation of secondary growth +relationship: positively_regulates GO:0080117 ! secondary growth + +[Term] +id: GO:2000606 +name: regulation of cell proliferation involved in mesonephros development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] +is_a: GO:1901722 ! regulation of cell proliferation involved in kidney development +relationship: regulates GO:0061209 ! cell proliferation involved in mesonephros development + +[Term] +id: GO:2000607 +name: negative regulation of cell proliferation involved in mesonephros development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] +is_a: GO:1901723 ! negative regulation of cell proliferation involved in kidney development +is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development +relationship: negatively_regulates GO:0061209 ! cell proliferation involved in mesonephros development + +[Term] +id: GO:2000608 +name: positive regulation of cell proliferation involved in mesonephros development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol] +is_a: GO:1901724 ! positive regulation of cell proliferation involved in kidney development +is_a: GO:2000606 ! regulation of cell proliferation involved in mesonephros development +relationship: positively_regulates GO:0061209 ! cell proliferation involved in mesonephros development + +[Term] +id: GO:2000609 +name: regulation of thyroid hormone generation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0032350 ! regulation of hormone metabolic process +is_a: GO:0051171 ! regulation of nitrogen compound metabolic process +relationship: regulates GO:0006590 ! thyroid hormone generation + +[Term] +id: GO:2000610 +name: negative regulation of thyroid hormone generation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol] +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:0032351 ! negative regulation of hormone metabolic process +is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process +is_a: GO:2000609 ! regulation of thyroid hormone generation +relationship: negatively_regulates GO:0006590 ! thyroid hormone generation + +[Term] +id: GO:2000611 +name: positive regulation of thyroid hormone generation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:0032352 ! positive regulation of hormone metabolic process +is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process +is_a: GO:2000609 ! regulation of thyroid hormone generation +relationship: positively_regulates GO:0006590 ! thyroid hormone generation + +[Term] +id: GO:2000612 +name: regulation of thyroid-stimulating hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] +synonym: "regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] +synonym: "regulation of TSH secretion" EXACT [GOC:obol] +is_a: GO:0090276 ! regulation of peptide hormone secretion +relationship: regulates GO:0070460 ! thyroid-stimulating hormone secretion + +[Term] +id: GO:2000613 +name: negative regulation of thyroid-stimulating hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] +synonym: "negative regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] +synonym: "negative regulation of TSH secretion" EXACT [GOC:obol] +is_a: GO:0090278 ! negative regulation of peptide hormone secretion +is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion +relationship: negatively_regulates GO:0070460 ! thyroid-stimulating hormone secretion + +[Term] +id: GO:2000614 +name: positive regulation of thyroid-stimulating hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol] +synonym: "positive regulation of thyroid stimulating hormone secretion" EXACT [GOC:obol] +synonym: "positive regulation of TSH secretion" EXACT [GOC:obol] +is_a: GO:0090277 ! positive regulation of peptide hormone secretion +is_a: GO:2000612 ! regulation of thyroid-stimulating hormone secretion +relationship: positively_regulates GO:0070460 ! thyroid-stimulating hormone secretion + +[Term] +id: GO:2000615 +name: regulation of histone H3-K9 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] +synonym: "regulation of histone H3 acetylation at K9" EXACT [GOC:obol] +synonym: "regulation of histone H3K9 acetylation" EXACT [GOC:obol] +is_a: GO:0035065 ! regulation of histone acetylation +relationship: regulates GO:0043970 ! histone H3-K9 acetylation + +[Term] +id: GO:2000616 +name: negative regulation of histone H3-K9 acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] +synonym: "negative regulation of histone H3 acetylation at K9" EXACT [GOC:obol] +synonym: "negative regulation of histone H3K9 acetylation" EXACT [GOC:obol] +is_a: GO:0035067 ! negative regulation of histone acetylation +is_a: GO:2000615 ! regulation of histone H3-K9 acetylation +relationship: negatively_regulates GO:0043970 ! histone H3-K9 acetylation + +[Term] +id: GO:2000617 +name: positive regulation of histone H3-K9 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF] +synonym: "positive regulation of histone H3 acetylation at K9" EXACT [GOC:obol] +synonym: "positive regulation of histone H3K9 acetylation" EXACT [GOC:obol] +is_a: GO:0035066 ! positive regulation of histone acetylation +is_a: GO:2000615 ! regulation of histone H3-K9 acetylation +relationship: positively_regulates GO:0043970 ! histone H3-K9 acetylation + +[Term] +id: GO:2000618 +name: regulation of histone H4-K16 acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] +synonym: "regulation of histone H4 acetylation at K16" EXACT [GOC:obol] +is_a: GO:0090239 ! regulation of histone H4 acetylation +relationship: regulates GO:0043984 ! histone H4-K16 acetylation + +[Term] +id: GO:2000619 +name: negative regulation of histone H4-K16 acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] +synonym: "negative regulation of histone H4 acetylation at K16" EXACT [GOC:obol] +is_a: GO:0090241 ! negative regulation of histone H4 acetylation +is_a: GO:2000618 ! regulation of histone H4-K16 acetylation +relationship: negatively_regulates GO:0043984 ! histone H4-K16 acetylation + +[Term] +id: GO:2000620 +name: positive regulation of histone H4-K16 acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF] +synonym: "positive regulation of histone H4 acetylation at K16" EXACT [GOC:obol] +is_a: GO:0090240 ! positive regulation of histone H4 acetylation +is_a: GO:2000618 ! regulation of histone H4-K16 acetylation +relationship: positively_regulates GO:0043984 ! histone H4-K16 acetylation + +[Term] +id: GO:2000621 +name: regulation of DNA replication termination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol] +is_a: GO:0051052 ! regulation of DNA metabolic process +is_a: GO:0090329 ! regulation of DNA-dependent DNA replication +relationship: regulates GO:0006274 ! DNA replication termination + +[Term] +id: GO:2000622 +name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] +synonym: "regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] +synonym: "regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] +synonym: "regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] +synonym: "regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] +is_a: GO:0061013 ! regulation of mRNA catabolic process +relationship: regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay + +[Term] +id: GO:2000623 +name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] +synonym: "negative regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "negative regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] +synonym: "negative regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] +synonym: "negative regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "negative regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] +synonym: "negative regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] +is_a: GO:1902373 ! negative regulation of mRNA catabolic process +is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +relationship: negatively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay + +[Term] +id: GO:2000624 +name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol] +synonym: "positive regulation of mRNA breakdown, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "positive regulation of mRNA catabolic process, nonsense-mediated" EXACT [GOC:obol] +synonym: "positive regulation of mRNA catabolism, nonsense-mediated" EXACT [GOC:obol] +synonym: "positive regulation of mRNA degradation, nonsense-mediated decay" EXACT [GOC:obol] +synonym: "positive regulation of nonsense-mediated mRNA decay" EXACT [GOC:obol] +synonym: "positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [GOC:obol] +is_a: GO:0061014 ! positive regulation of mRNA catabolic process +is_a: GO:2000622 ! regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay +relationship: positively_regulates GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay + +[Term] +id: GO:2000625 +name: regulation of miRNA catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of miRNA catabolic process." [GOC:dph] +synonym: "regulation of microRNA catabolic process" EXACT [GOC:obol] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:2000628 ! regulation of miRNA metabolic process +relationship: regulates GO:0010587 ! miRNA catabolic process + +[Term] +id: GO:2000626 +name: negative regulation of miRNA catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph] +synonym: "negative regulation of microRNA catabolic process" EXACT [GOC:obol] +is_a: GO:1902369 ! negative regulation of RNA catabolic process +is_a: GO:2000625 ! regulation of miRNA catabolic process +is_a: GO:2000629 ! negative regulation of miRNA metabolic process +relationship: negatively_regulates GO:0010587 ! miRNA catabolic process + +[Term] +id: GO:2000627 +name: positive regulation of miRNA catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph] +synonym: "positive regulation of microRNA catabolic process" EXACT [GOC:obol] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:2000625 ! regulation of miRNA catabolic process +is_a: GO:2000630 ! positive regulation of miRNA metabolic process +relationship: positively_regulates GO:0010587 ! miRNA catabolic process + +[Term] +id: GO:2000628 +name: regulation of miRNA metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of miRNA metabolic process." [GOC:dph] +synonym: "regulation of microRNA metabolic process" EXACT [GOC:obol] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0010586 ! miRNA metabolic process + +[Term] +id: GO:2000629 +name: negative regulation of miRNA metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph] +synonym: "negative regulation of microRNA metabolic process" EXACT [GOC:obol] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:2000628 ! regulation of miRNA metabolic process +relationship: negatively_regulates GO:0010586 ! miRNA metabolic process + +[Term] +id: GO:2000630 +name: positive regulation of miRNA metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph] +synonym: "positive regulation of microRNA metabolic process" EXACT [GOC:obol] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:2000628 ! regulation of miRNA metabolic process +relationship: positively_regulates GO:0010586 ! miRNA metabolic process + +[Term] +id: GO:2000631 +name: regulation of pre-miRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] +synonym: "regulation of pre-microRNA processing" EXACT [] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0031054 ! pre-miRNA processing + +[Term] +id: GO:2000632 +name: negative regulation of pre-miRNA processing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] +synonym: "negative regulation of pre-microRNA processing" EXACT [GOC:obol] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:2000631 ! regulation of pre-miRNA processing +relationship: negatively_regulates GO:0031054 ! pre-miRNA processing + +[Term] +id: GO:2000633 +name: positive regulation of pre-miRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl] +synonym: "positive regulation of pre-microRNA processing" EXACT [GOC:obol] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:2000631 ! regulation of pre-miRNA processing +relationship: positively_regulates GO:0031054 ! pre-miRNA processing + +[Term] +id: GO:2000634 +name: regulation of primary miRNA processing +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] +synonym: "regulation of pri-miRNA processing" EXACT [GOC:obol] +synonym: "regulation of primary microRNA processing" EXACT [GOC:obol] +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0031053 ! primary miRNA processing + +[Term] +id: GO:2000635 +name: negative regulation of primary miRNA processing +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] +synonym: "negative regulation of pri-miRNA processing" EXACT [GOC:obol] +synonym: "negative regulation of primary microRNA processing" EXACT [GOC:obol] +is_a: GO:0051253 ! negative regulation of RNA metabolic process +is_a: GO:2000634 ! regulation of primary miRNA processing +relationship: negatively_regulates GO:0031053 ! primary miRNA processing + +[Term] +id: GO:2000636 +name: positive regulation of primary miRNA processing +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl] +synonym: "positive regulation of pri-miRNA processing" EXACT [GOC:obol] +synonym: "positive regulation of primary microRNA processing" EXACT [GOC:obol] +is_a: GO:0051254 ! positive regulation of RNA metabolic process +is_a: GO:2000634 ! regulation of primary miRNA processing +relationship: positively_regulates GO:0031053 ! primary miRNA processing + +[Term] +id: GO:2000637 +name: positive regulation of gene silencing by miRNA +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA." [GOC:dph] +synonym: "positive regulation of gene silencing by microRNA" RELATED [GOC:pr] +synonym: "positive regulation of microRNA-mediated gene silencing" EXACT [GOC:obol] +synonym: "positive regulation of miRNA-mediated gene silencing" EXACT [GOC:obol] +is_a: GO:0060148 ! positive regulation of posttranscriptional gene silencing +is_a: GO:0060964 ! regulation of gene silencing by miRNA +relationship: positively_regulates GO:0035195 ! gene silencing by miRNA + +[Term] +id: GO:2000638 +name: regulation of SREBP signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] +synonym: "regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] +synonym: "regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0032933 ! SREBP signaling pathway + +[Term] +id: GO:2000639 +name: negative regulation of SREBP signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] +synonym: "negative regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] +synonym: "negative regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:2000638 ! regulation of SREBP signaling pathway +relationship: negatively_regulates GO:0032933 ! SREBP signaling pathway + +[Term] +id: GO:2000640 +name: positive regulation of SREBP signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF] +synonym: "positive regulation of SREBP-mediated signaling pathway" EXACT [GOC:bf, GOC:vw] +synonym: "positive regulation of SREBP-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2000638 ! regulation of SREBP signaling pathway +relationship: positively_regulates GO:0032933 ! SREBP signaling pathway + +[Term] +id: GO:2000641 +name: regulation of early endosome to late endosome transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] +is_a: GO:0060627 ! regulation of vesicle-mediated transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +relationship: regulates GO:0045022 ! early endosome to late endosome transport + +[Term] +id: GO:2000642 +name: negative regulation of early endosome to late endosome transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] +is_a: GO:1903650 ! negative regulation of cytoplasmic transport +is_a: GO:2000641 ! regulation of early endosome to late endosome transport +relationship: negatively_regulates GO:0045022 ! early endosome to late endosome transport + +[Term] +id: GO:2000643 +name: positive regulation of early endosome to late endosome transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF] +is_a: GO:1903651 ! positive regulation of cytoplasmic transport +is_a: GO:2000641 ! regulation of early endosome to late endosome transport +relationship: positively_regulates GO:0045022 ! early endosome to late endosome transport + +[Term] +id: GO:2000644 +name: regulation of receptor catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of receptor catabolic process." [GOC:BHF] +synonym: "regulation of receptor breakdown" EXACT [GOC:obol] +synonym: "regulation of receptor catabolism" EXACT [GOC:obol] +synonym: "regulation of receptor degradation" EXACT [GOC:obol] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:0032801 ! receptor catabolic process + +[Term] +id: GO:2000645 +name: negative regulation of receptor catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF] +synonym: "negative regulation of receptor breakdown" EXACT [GOC:obol] +synonym: "negative regulation of receptor catabolism" EXACT [GOC:obol] +synonym: "negative regulation of receptor degradation" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:2000644 ! regulation of receptor catabolic process +relationship: negatively_regulates GO:0032801 ! receptor catabolic process + +[Term] +id: GO:2000646 +name: positive regulation of receptor catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF] +synonym: "positive regulation of receptor breakdown" EXACT [GOC:obol] +synonym: "positive regulation of receptor catabolism" EXACT [GOC:obol] +synonym: "positive regulation of receptor degradation" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:2000644 ! regulation of receptor catabolic process +relationship: positively_regulates GO:0032801 ! receptor catabolic process + +[Term] +id: GO:2000647 +name: negative regulation of stem cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:0072091 ! regulation of stem cell proliferation +relationship: negatively_regulates GO:0072089 ! stem cell proliferation + +[Term] +id: GO:2000648 +name: positive regulation of stem cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph] +is_a: GO:0008284 ! positive regulation of cell population proliferation +is_a: GO:0072091 ! regulation of stem cell proliferation +relationship: positively_regulates GO:0072089 ! stem cell proliferation + +[Term] +id: GO:2000649 +name: regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1902305 ! regulation of sodium ion transmembrane transport + +[Term] +id: GO:2000650 +name: negative regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "negative regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1902306 ! negative regulation of sodium ion transmembrane transport +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:2000651 +name: positive regulation of sodium ion transmembrane transporter activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol] +synonym: "positive regulation of sodium transporter activity" EXACT [GOC:obol] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1902307 ! positive regulation of sodium ion transmembrane transport +is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity + +[Term] +id: GO:2000652 +name: regulation of secondary cell wall biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol] +synonym: "regulation of cellulose and pectin-containing secondary cell wall biogenesis" EXACT [GOC:obol] +synonym: "regulation of plant-type secondary cell wall biogenesis" EXACT [GOC:obol] +synonym: "regulation of secondary cell wall anabolism" RELATED [GOC:obol] +synonym: "regulation of secondary cell wall biosynthetic process" RELATED [GOC:obol] +synonym: "regulation of secondary cell wall formation" RELATED [GOC:obol] +synonym: "regulation of secondary cell wall synthesis" RELATED [GOC:obol] +is_a: GO:0044087 ! regulation of cellular component biogenesis +is_a: GO:1903338 ! regulation of cell wall organization or biogenesis +relationship: regulates GO:0009834 ! plant-type secondary cell wall biogenesis + +[Term] +id: GO:2000653 +name: regulation of genetic imprinting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of genetic imprinting." [GOC:BHF] +synonym: "regulation of DNA imprinting" EXACT [GOC:obol] +is_a: GO:0031445 ! regulation of heterochromatin assembly +relationship: regulates GO:0071514 ! genomic imprinting + +[Term] +id: GO:2000654 +name: regulation of cellular response to testosterone stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071394 ! cellular response to testosterone stimulus + +[Term] +id: GO:2000655 +name: negative regulation of cellular response to testosterone stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2000654 ! regulation of cellular response to testosterone stimulus +relationship: negatively_regulates GO:0071394 ! cellular response to testosterone stimulus + +[Term] +id: GO:2000656 +name: regulation of apolipoprotein binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:2000657 +name: negative regulation of apolipoprotein binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:2000656 ! regulation of apolipoprotein binding + +[Term] +id: GO:2000658 +name: positive regulation of apolipoprotein binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:2000656 ! regulation of apolipoprotein binding + +[Term] +id: GO:2000659 +name: regulation of interleukin-1-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] +synonym: "regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] +synonym: "regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway +relationship: regulates GO:0070498 ! interleukin-1-mediated signaling pathway + +[Term] +id: GO:2000660 +name: negative regulation of interleukin-1-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] +synonym: "negative regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] +synonym: "negative regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway +is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway +relationship: negatively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway + +[Term] +id: GO:2000661 +name: positive regulation of interleukin-1-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol] +synonym: "positive regulation of IL-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of IL-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of IL-1-mediated signaling pathway" EXACT [GOC:obol] +synonym: "positive regulation of interleukin-1 alpha-mediated signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of interleukin-1 beta-mediated signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of interleukin-1-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0001961 ! positive regulation of cytokine-mediated signaling pathway +is_a: GO:2000659 ! regulation of interleukin-1-mediated signaling pathway +relationship: positively_regulates GO:0070498 ! interleukin-1-mediated signaling pathway + +[Term] +id: GO:2000668 +name: regulation of dendritic cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "regulation of dendritic cell apoptosis" NARROW [] +is_a: GO:2000106 ! regulation of leukocyte apoptotic process +relationship: regulates GO:0097048 ! dendritic cell apoptotic process + +[Term] +id: GO:2000669 +name: negative regulation of dendritic cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "negative regulation of dendritic cell apoptosis" NARROW [] +is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process +is_a: GO:2000668 ! regulation of dendritic cell apoptotic process +relationship: negatively_regulates GO:0097048 ! dendritic cell apoptotic process + +[Term] +id: GO:2000670 +name: positive regulation of dendritic cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "positive regulation of dendritic cell apoptosis" NARROW [] +is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process +is_a: GO:2000668 ! regulation of dendritic cell apoptotic process +relationship: positively_regulates GO:0097048 ! dendritic cell apoptotic process + +[Term] +id: GO:2000671 +name: regulation of motor neuron apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "regulation of motoneuron apoptosis" EXACT [GOC:obol] +synonym: "regulation of motor neuron apoptosis" NARROW [] +is_a: GO:0043523 ! regulation of neuron apoptotic process +relationship: regulates GO:0097049 ! motor neuron apoptotic process + +[Term] +id: GO:2000672 +name: negative regulation of motor neuron apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "negative regulation of motoneuron apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of motor neuron apoptosis" NARROW [] +is_a: GO:0043524 ! negative regulation of neuron apoptotic process +is_a: GO:2000671 ! regulation of motor neuron apoptotic process +relationship: negatively_regulates GO:0097049 ! motor neuron apoptotic process + +[Term] +id: GO:2000673 +name: positive regulation of motor neuron apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "positive regulation of motoneuron apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of motor neuron apoptosis" NARROW [] +is_a: GO:0043525 ! positive regulation of neuron apoptotic process +is_a: GO:2000671 ! regulation of motor neuron apoptotic process +relationship: positively_regulates GO:0097049 ! motor neuron apoptotic process + +[Term] +id: GO:2000674 +name: regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904035 ! regulation of epithelial cell apoptotic process +relationship: regulates GO:0097050 ! type B pancreatic cell apoptotic process + +[Term] +id: GO:2000675 +name: negative regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "negative regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "negative regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904036 ! negative regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +relationship: negatively_regulates GO:0097050 ! type B pancreatic cell apoptotic process + +[Term] +id: GO:2000676 +name: positive regulation of type B pancreatic cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "positive regulation of pancreatic B cell apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of pancreatic beta cell apoptosis" EXACT [GOC:obol] +synonym: "positive regulation of type B pancreatic cell apoptosis" NARROW [] +is_a: GO:1904037 ! positive regulation of epithelial cell apoptotic process +is_a: GO:2000674 ! regulation of type B pancreatic cell apoptotic process +relationship: positively_regulates GO:0097050 ! type B pancreatic cell apoptotic process + +[Term] +id: GO:2000677 +name: regulation of transcription regulatory region DNA binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] +is_a: GO:0051101 ! regulation of DNA binding + +[Term] +id: GO:2000678 +name: negative regulation of transcription regulatory region DNA binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] +is_a: GO:0043392 ! negative regulation of DNA binding +is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding + +[Term] +id: GO:2000679 +name: positive regulation of transcription regulatory region DNA binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding." [GOC:obol] +is_a: GO:0043388 ! positive regulation of DNA binding +is_a: GO:2000677 ! regulation of transcription regulatory region DNA binding + +[Term] +id: GO:2000680 +name: obsolete regulation of rubidium ion transport +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transport." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "regulation of Rb+ transport" EXACT [GOC:obol] +synonym: "regulation of rubidium cation transport" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000681 +name: obsolete negative regulation of rubidium ion transport +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transport." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "negative regulation of Rb+ transport" EXACT [GOC:obol] +synonym: "negative regulation of rubidium cation transport" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000682 +name: obsolete positive regulation of rubidium ion transport +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transport." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "positive regulation of Rb+ transport" EXACT [GOC:obol] +synonym: "positive regulation of rubidium cation transport" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000683 +name: regulation of cellular response to X-ray +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to X-ray." [GOC:obol] +synonym: "regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +is_a: GO:0050794 ! regulation of cellular process +relationship: regulates GO:0071481 ! cellular response to X-ray + +[Term] +id: GO:2000684 +name: negative regulation of cellular response to X-ray +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to X-ray." [GOC:obol] +synonym: "negative regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2000683 ! regulation of cellular response to X-ray +relationship: negatively_regulates GO:0071481 ! cellular response to X-ray + +[Term] +id: GO:2000685 +name: positive regulation of cellular response to X-ray +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to X-ray." [GOC:obol] +synonym: "positive regulation of cellular response to X-ray radiation stimulus" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2000683 ! regulation of cellular response to X-ray +relationship: positively_regulates GO:0071481 ! cellular response to X-ray + +[Term] +id: GO:2000686 +name: obsolete regulation of rubidium ion transmembrane transporter activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] +synonym: "regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] +synonym: "regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000687 +name: obsolete negative regulation of rubidium ion transmembrane transporter activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "negative regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] +synonym: "negative regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] +synonym: "negative regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000688 +name: obsolete positive regulation of rubidium ion transmembrane transporter activity +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of rubidium ion transmembrane transporter activity." [GOC:yaf] +comment: This term has been obsoleted because it represents an assay, and not a physiological process. +synonym: "positive regulation of Rb+ transmembrane transporter activity" EXACT [GOC:obol] +synonym: "positive regulation of rubidium cation transmembrane transporter activity" EXACT [GOC:obol] +synonym: "positive regulation of rubidium transmembrane transporter activity" RELATED [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000689 +name: actomyosin contractile ring assembly actin filament organization +namespace: biological_process +def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] +synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol] +synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol] +synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] +synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +synonym: "actin filament organization involved in cytokinetic actomyosin contractile ring assembly" EXACT [] +synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol] +synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol] +synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] +synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +is_a: GO:0007015 ! actin filament organization +is_a: GO:0022402 ! cell cycle process +relationship: part_of GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:2000690 +name: regulation of cardiac muscle cell myoblast differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] +synonym: "regulation of cardiac myoblast differentiation" RELATED [GOC:obol] +synonym: "regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] +is_a: GO:0045661 ! regulation of myoblast differentiation +is_a: GO:0051890 ! regulation of cardioblast differentiation +relationship: regulates GO:0060379 ! cardiac muscle cell myoblast differentiation + +[Term] +id: GO:2000691 +name: negative regulation of cardiac muscle cell myoblast differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] +synonym: "negative regulation of cardiac myoblast differentiation" RELATED [GOC:obol] +synonym: "negative regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] +is_a: GO:0045662 ! negative regulation of myoblast differentiation +is_a: GO:0051892 ! negative regulation of cardioblast differentiation +is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation +relationship: negatively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation + +[Term] +id: GO:2000692 +name: negative regulation of seed maturation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation." [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000034 ! regulation of seed maturation +is_a: GO:2000242 ! negative regulation of reproductive process +relationship: negatively_regulates GO:0010431 ! seed maturation + +[Term] +id: GO:2000693 +name: positive regulation of seed maturation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of seed maturation." [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000034 ! regulation of seed maturation +is_a: GO:2000243 ! positive regulation of reproductive process +relationship: positively_regulates GO:0010431 ! seed maturation + +[Term] +id: GO:2000694 +name: regulation of phragmoplast microtubule organization +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phragmoplast microtubule organization." [GOC:obol] +synonym: "regulation of phragmoplast microtubule cytoskeleton organization" EXACT [GOC:obol] +synonym: "regulation of phragmoplast microtubule organisation" EXACT [GOC:mah] +is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization +relationship: regulates GO:0080175 ! phragmoplast microtubule organization + +[Term] +id: GO:2000696 +name: regulation of epithelial cell differentiation involved in kidney development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] +is_a: GO:0030856 ! regulation of epithelial cell differentiation +relationship: regulates GO:0035850 ! epithelial cell differentiation involved in kidney development + +[Term] +id: GO:2000697 +name: negative regulation of epithelial cell differentiation involved in kidney development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] +is_a: GO:0030857 ! negative regulation of epithelial cell differentiation +is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development +relationship: negatively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development + +[Term] +id: GO:2000698 +name: positive regulation of epithelial cell differentiation involved in kidney development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation involved in kidney development." [GOC:mtg_kidney_jan10, GOC:yaf] +is_a: GO:0030858 ! positive regulation of epithelial cell differentiation +is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development +relationship: positively_regulates GO:0035850 ! epithelial cell differentiation involved in kidney development + +[Term] +id: GO:2000699 +name: fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:yaf] +synonym: "FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway +relationship: part_of GO:0060676 ! ureteric bud formation + +[Term] +id: GO:2000700 +name: positive regulation of cardiac muscle cell myoblast differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation." [GOC:obol] +synonym: "positive regulation of cardiac myoblast differentiation" RELATED [GOC:obol] +synonym: "positive regulation of myocardial precursor cell differentiation" EXACT [GOC:obol] +is_a: GO:0045663 ! positive regulation of myoblast differentiation +is_a: GO:0051891 ! positive regulation of cardioblast differentiation +is_a: GO:2000690 ! regulation of cardiac muscle cell myoblast differentiation +relationship: positively_regulates GO:0060379 ! cardiac muscle cell myoblast differentiation + +[Term] +id: GO:2000701 +name: glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands that contributes to the formation of the ureteric bud from the Wolffian duct." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0035860 ! glial cell-derived neurotrophic factor receptor signaling pathway +relationship: part_of GO:0060676 ! ureteric bud formation + +[Term] +id: GO:2000702 +name: regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0040036 ! regulation of fibroblast growth factor receptor signaling pathway +relationship: regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000703 +name: negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "negative regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0040037 ! negative regulation of fibroblast growth factor receptor signaling pathway +is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +relationship: negatively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000704 +name: positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "positive regulation of FGF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of FGF receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of FGFR signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of fibroblast growth factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of fibroblast growth factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0045743 ! positive regulation of fibroblast growth factor receptor signaling pathway +is_a: GO:2000702 ! regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation +relationship: positively_regulates GO:2000699 ! fibroblast growth factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000705 +name: regulation of dense core granule biogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] +is_a: GO:0044087 ! regulation of cellular component biogenesis +relationship: regulates GO:0061110 ! dense core granule biogenesis + +[Term] +id: GO:2000706 +name: negative regulation of dense core granule biogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:2000705 ! regulation of dense core granule biogenesis +relationship: negatively_regulates GO:0061110 ! dense core granule biogenesis + +[Term] +id: GO:2000707 +name: positive regulation of dense core granule biogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis." [GOC:obol] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:2000705 ! regulation of dense core granule biogenesis +relationship: positively_regulates GO:0061110 ! dense core granule biogenesis + +[Term] +id: GO:2000708 +name: myosin filament organization involved in cytokinetic actomyosin contractile ring assembly +namespace: biological_process +def: "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] +synonym: "myosin filament assembly or disassembly of constriction ring assembly" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly" EXACT [GOC:mah] +synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol] +synonym: "myosin filament organization of contractile ring assembly" EXACT [GOC:obol] +synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] +synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "myosin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "myosin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "myosin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of constriction ring assembly" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] +synonym: "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] +is_a: GO:0022402 ! cell cycle process +is_a: GO:0031033 ! myosin filament organization +relationship: part_of GO:0000915 ! actomyosin contractile ring assembly + +[Term] +id: GO:2000709 +name: regulation of maintenance of meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion +relationship: regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000710 +name: negative regulation of maintenance of meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "negative regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] +is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric +relationship: negatively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000711 +name: positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "positive regulation of maintenance of centromeric meiotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at meiosis I" EXACT [GOC:obol] +is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000709 ! regulation of maintenance of meiotic sister chromatid cohesion, centromeric +relationship: positively_regulates GO:0035875 ! maintenance of meiotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000712 +name: regulation of maintenance of meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] +is_a: GO:0034094 ! regulation of maintenance of meiotic sister chromatid cohesion +relationship: regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms + +[Term] +id: GO:2000713 +name: negative regulation of maintenance of meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "negative regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] +is_a: GO:0034095 ! negative regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms +relationship: negatively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms + +[Term] +id: GO:2000714 +name: positive regulation of maintenance of meiotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "positive regulation of maintenance of meiotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at meiosis I" EXACT [GOC:obol] +is_a: GO:0034096 ! positive regulation of maintenance of meiotic sister chromatid cohesion +is_a: GO:2000712 ! regulation of maintenance of meiotic sister chromatid cohesion, arms +relationship: positively_regulates GO:0035876 ! maintenance of meiotic sister chromatid cohesion, arms + +[Term] +id: GO:2000715 +name: regulation of maintenance of mitotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +relationship: regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms + +[Term] +id: GO:2000716 +name: negative regulation of maintenance of mitotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] +is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms +relationship: negatively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms + +[Term] +id: GO:2000717 +name: positive regulation of maintenance of mitotic sister chromatid cohesion, arms +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion along the chromosome arms." [GOC:mah] +synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion along arms" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of sister chromatin cohesion along arms at mitosis" EXACT [GOC:obol] +is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:2000715 ! regulation of maintenance of mitotic sister chromatid cohesion, arms +relationship: positively_regulates GO:0071959 ! maintenance of mitotic sister chromatid cohesion, arms + +[Term] +id: GO:2000718 +name: regulation of maintenance of mitotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] +is_a: GO:0034182 ! regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:0070602 ! regulation of centromeric sister chromatid cohesion +relationship: regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000719 +name: negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "negative regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "negative regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] +is_a: GO:0034183 ! negative regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric +relationship: negatively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000720 +name: positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." [GOC:mah] +synonym: "positive regulation of maintenance of centromeric mitotic sister chromatin cohesion" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of mitotic sister chromatin cohesion at centromere" EXACT [GOC:obol] +synonym: "positive regulation of maintenance of sister chromatin cohesion at centromere at mitosis" EXACT [GOC:obol] +is_a: GO:0034184 ! positive regulation of maintenance of mitotic sister chromatid cohesion +is_a: GO:2000718 ! regulation of maintenance of mitotic sister chromatid cohesion, centromeric +relationship: positively_regulates GO:0071960 ! maintenance of mitotic sister chromatid cohesion, centromeric + +[Term] +id: GO:2000721 +name: positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] +synonym: "activation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "activation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "activation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "activation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of global transcription from Pol II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of global transcription from Pol II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase II promoter, global of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "stimulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "stimulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "stimulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "stimulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "up regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "up regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "up regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "up regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "up-regulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "up-regulation of transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "up-regulation of transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "upregulation of global transcription from RNA polymerase II promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "upregulation of global transcription from RNA polymerase II promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:2000722 +name: regulation of cardiac vascular smooth muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] +synonym: "regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] +is_a: GO:1905063 ! regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:2000723 +name: negative regulation of cardiac vascular smooth muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] +synonym: "negative regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] +is_a: GO:1905064 ! negative regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905208 ! negative regulation of cardiocyte differentiation +is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation +relationship: negatively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:2000724 +name: positive regulation of cardiac vascular smooth muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac vascular smooth muscle cell differentiation." [GOC:BHF] +synonym: "positive regulation of heart vascular smooth muscle cell differentiation" EXACT [GOC:obol] +is_a: GO:1905065 ! positive regulation of vascular associated smooth muscle cell differentiation +is_a: GO:1905209 ! positive regulation of cardiocyte differentiation +is_a: GO:2000722 ! regulation of cardiac vascular smooth muscle cell differentiation +relationship: positively_regulates GO:0060947 ! cardiac vascular smooth muscle cell differentiation + +[Term] +id: GO:2000725 +name: regulation of cardiac muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] +synonym: "regulation of cardiomyocyte differentiation" EXACT [GOC:obol] +synonym: "regulation of heart muscle cell differentiation" RELATED [GOC:obol] +is_a: GO:0051153 ! regulation of striated muscle cell differentiation +is_a: GO:1905207 ! regulation of cardiocyte differentiation +relationship: regulates GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:2000726 +name: negative regulation of cardiac muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] +synonym: "negative regulation of cardiomyocyte differentiation" EXACT [GOC:obol] +synonym: "negative regulation of heart muscle cell differentiation" RELATED [GOC:obol] +is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation +is_a: GO:1905208 ! negative regulation of cardiocyte differentiation +is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation +relationship: negatively_regulates GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:2000727 +name: positive regulation of cardiac muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation." [GOC:BHF] +synonym: "positive regulation of cardiomyocyte differentiation" EXACT [GOC:obol] +synonym: "positive regulation of heart muscle cell differentiation" RELATED [GOC:obol] +is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation +is_a: GO:1905209 ! positive regulation of cardiocyte differentiation +is_a: GO:2000725 ! regulation of cardiac muscle cell differentiation +relationship: positively_regulates GO:0055007 ! cardiac muscle cell differentiation + +[Term] +id: GO:2000728 +name: regulation of mRNA export from nucleus in response to heat stress +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mRNA export from nucleus in response to heat stress." [PMID:15210706] +synonym: "regulation of mRNA export from cell nucleus during heat stress" EXACT [GOC:obol] +synonym: "regulation of mRNA export from nucleus during heat stress" RELATED [GOC:obol] +is_a: GO:0010793 ! regulation of mRNA export from nucleus +is_a: GO:1900034 ! regulation of cellular response to heat +relationship: regulates GO:0031990 ! mRNA export from nucleus in response to heat stress + +[Term] +id: GO:2000729 +name: positive regulation of mesenchymal cell proliferation involved in ureter development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development." [GOC:obol] +synonym: "positive regulation of ureter mesenchymal cell proliferation" RELATED [GOC:obol] +synonym: "positive regulation of ureteral mesenchymal cell proliferation" RELATED [GOC:obol] +is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0072199 ! regulation of mesenchymal cell proliferation involved in ureter development +relationship: positively_regulates GO:0072198 ! mesenchymal cell proliferation involved in ureter development + +[Term] +id: GO:2000730 +name: regulation of termination of RNA polymerase I transcription +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] +synonym: "regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] +synonym: "regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] +synonym: "regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] +is_a: GO:0006356 ! regulation of transcription by RNA polymerase I +is_a: GO:0031554 ! regulation of DNA-templated transcription, termination +relationship: regulates GO:0006363 ! termination of RNA polymerase I transcription + +[Term] +id: GO:2000731 +name: negative regulation of termination of RNA polymerase I transcription +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] +synonym: "negative regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] +synonym: "negative regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] +synonym: "negative regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] +is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I +is_a: GO:0060567 ! negative regulation of DNA-templated transcription, termination +is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription +relationship: negatively_regulates GO:0006363 ! termination of RNA polymerase I transcription + +[Term] +id: GO:2000732 +name: positive regulation of termination of RNA polymerase I transcription +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription." [GOC:obol] +synonym: "positive regulation of RNA polymerase I transcription termination" EXACT [GOC:obol] +synonym: "positive regulation of transcription termination from Pol I promoter" EXACT [GOC:obol] +synonym: "positive regulation of transcription termination from RNA polymerase I promoter" EXACT [GOC:obol] +is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I +is_a: GO:0060566 ! positive regulation of DNA-templated transcription, termination +is_a: GO:2000730 ! regulation of termination of RNA polymerase I transcription +relationship: positively_regulates GO:0006363 ! termination of RNA polymerase I transcription + +[Term] +id: GO:2000733 +name: regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] +synonym: "regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000734 +name: negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] +synonym: "negative regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "negative regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +relationship: negatively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000735 +name: positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation." [GOC:obol] +synonym: "positive regulation of GDNF receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of glial cell derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of glial cell line-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway of ureteric bud formation" EXACT [GOC:obol] +synonym: "positive regulation of glial cell-derived neurotrophic factor receptor signalling pathway of ureteric bud formation" EXACT [GOC:obol] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2000733 ! regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation +relationship: positively_regulates GO:2000701 ! glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation + +[Term] +id: GO:2000736 +name: regulation of stem cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of stem cell differentiation." [GOC:obol] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0048863 ! stem cell differentiation + +[Term] +id: GO:2000737 +name: negative regulation of stem cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation." [GOC:obol] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: negatively_regulates GO:0048863 ! stem cell differentiation + +[Term] +id: GO:2000738 +name: positive regulation of stem cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of stem cell differentiation." [GOC:obol] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: positively_regulates GO:0048863 ! stem cell differentiation + +[Term] +id: GO:2000739 +name: regulation of mesenchymal stem cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] +is_a: GO:2000736 ! regulation of stem cell differentiation +relationship: regulates GO:0072497 ! mesenchymal stem cell differentiation + +[Term] +id: GO:2000740 +name: negative regulation of mesenchymal stem cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] +is_a: GO:2000737 ! negative regulation of stem cell differentiation +is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation +relationship: negatively_regulates GO:0072497 ! mesenchymal stem cell differentiation + +[Term] +id: GO:2000741 +name: positive regulation of mesenchymal stem cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell differentiation." [GOC:obol] +is_a: GO:2000738 ! positive regulation of stem cell differentiation +is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation +relationship: positively_regulates GO:0072497 ! mesenchymal stem cell differentiation + +[Term] +id: GO:2000742 +name: regulation of anterior head development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anterior head development." [GOC:obol] +is_a: GO:0050793 ! regulation of developmental process +relationship: regulates GO:0097065 ! anterior head development + +[Term] +id: GO:2000743 +name: negative regulation of anterior head development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterior head development." [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2000742 ! regulation of anterior head development +relationship: negatively_regulates GO:0097065 ! anterior head development + +[Term] +id: GO:2000744 +name: positive regulation of anterior head development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anterior head development." [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2000742 ! regulation of anterior head development +relationship: positively_regulates GO:0097065 ! anterior head development + +[Term] +id: GO:2000745 +name: obsolete positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation +namespace: biological_process +def: "OBSOLETE. Any positive regulation of transcription from RNA polymerase III promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] +comment: This term was made obsolete because it was added in error. +synonym: "activation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "activation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "positive regulation of transcription from Pol III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase III promoter involved in smooth muscle cell differentiation" EXACT [] +synonym: "positive regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "stimulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "stimulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "up regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "up regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "up-regulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "up-regulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "upregulation of transcription from RNA polymerase III promoter of nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "upregulation of transcription from RNA polymerase III promoter of smooth muscle cell differentiation" EXACT [GOC:obol] +is_obsolete: true +consider: GO:0048665 +consider: GO:0051145 + +[Term] +id: GO:2000746 +name: regulation of defecation rhythm +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of defecation rhythm." [GOC:kmv] +synonym: "regulation of defecation behavior" RELATED [GOC:obol] +synonym: "regulation of defecation cycle" EXACT [GOC:obol] +synonym: "regulation of defecation motor program" EXACT [GOC:obol] +synonym: "regulation of DMP" EXACT [GOC:obol] +is_a: GO:2000292 ! regulation of defecation +relationship: regulates GO:0035882 ! defecation rhythm + +[Term] +id: GO:2000747 +name: negative regulation of defecation rhythm +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm." [GOC:kmv] +synonym: "negative regulation of defecation behavior" RELATED [GOC:obol] +synonym: "negative regulation of defecation cycle" EXACT [GOC:obol] +synonym: "negative regulation of defecation motor program" EXACT [GOC:obol] +synonym: "negative regulation of DMP" EXACT [GOC:obol] +is_a: GO:2000293 ! negative regulation of defecation +is_a: GO:2000746 ! regulation of defecation rhythm +relationship: negatively_regulates GO:0035882 ! defecation rhythm + +[Term] +id: GO:2000748 +name: positive regulation of defecation rhythm +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of defecation rhythm." [GOC:kmv] +synonym: "positive regulation of defecation behavior" RELATED [GOC:obol] +synonym: "positive regulation of defecation cycle" EXACT [GOC:obol] +synonym: "positive regulation of defecation motor program" EXACT [GOC:obol] +synonym: "positive regulation of DMP" EXACT [GOC:obol] +is_a: GO:2000294 ! positive regulation of defecation +is_a: GO:2000746 ! regulation of defecation rhythm +relationship: positively_regulates GO:0035882 ! defecation rhythm + +[Term] +id: GO:2000749 +name: positive regulation of rDNA heterochromatin assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of assembly of rDNA heterochromatin." [PMID:10899127] +synonym: "positive regulation of chromatin silencing at rDNA" BROAD [] +synonym: "positive regulation of chromatin silencing at ribosomal DNA" BROAD [GOC:obol] +synonym: "positive regulation of heterochromatic silencing at rDNA" BROAD [GOC:obol] +synonym: "positive regulation of rDNA chromatin silencing" BROAD [GOC:obol] +synonym: "positive regulation of ribosomal DNA heterochromatin assembly" EXACT [] +is_a: GO:0031453 ! positive regulation of heterochromatin assembly +is_a: GO:0061187 ! regulation of ribosomal DNA heterochromatin assembly +relationship: positively_regulates GO:0000183 ! rDNA heterochromatin assembly + +[Term] +id: GO:2000750 +name: negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:mah] +is_a: GO:2000100 ! regulation of establishment or maintenance of bipolar cell polarity regulating cell shape +is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: negatively_regulates GO:0061246 ! establishment or maintenance of bipolar cell polarity regulating cell shape + +[Term] +id: GO:2000751 +name: histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore +namespace: biological_process +def: "Any histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol] +synonym: "histone H3-T3 phosphorylation of chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol] +synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol] +synonym: "histone H3-T3 phosphorylation of chromosome passenger complex localization to kinetochore" EXACT [GOC:obol] +synonym: "histone H3-T3 phosphorylation of CPC complex localization to kinetochore" EXACT [GOC:obol] +synonym: "histone H3-T3 phosphorylation of CPC localization to kinetochore" EXACT [GOC:obol] +is_a: GO:0072355 ! histone H3-T3 phosphorylation +relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore + +[Term] +id: GO:2000752 +name: regulation of glucosylceramide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF] +synonym: "regulation of glucosylceramide breakdown" EXACT [GOC:obol] +synonym: "regulation of glucosylceramide catabolism" EXACT [GOC:obol] +synonym: "regulation of glucosylceramide degradation" EXACT [GOC:obol] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0050994 ! regulation of lipid catabolic process +is_a: GO:1905038 ! regulation of membrane lipid metabolic process +relationship: regulates GO:0006680 ! glucosylceramide catabolic process + +[Term] +id: GO:2000753 +name: positive regulation of glucosylceramide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucosylceramide catabolic process." [GOC:BHF] +synonym: "positive regulation of glucosylceramide breakdown" EXACT [GOC:obol] +synonym: "positive regulation of glucosylceramide catabolism" EXACT [GOC:obol] +synonym: "positive regulation of glucosylceramide degradation" EXACT [GOC:obol] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0050996 ! positive regulation of lipid catabolic process +is_a: GO:2000752 ! regulation of glucosylceramide catabolic process +relationship: positively_regulates GO:0006680 ! glucosylceramide catabolic process + +[Term] +id: GO:2000754 +name: regulation of sphingomyelin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF] +synonym: "regulation of sphingomyelin breakdown" EXACT [GOC:obol] +synonym: "regulation of sphingomyelin catabolism" EXACT [GOC:obol] +synonym: "regulation of sphingomyelin degradation" EXACT [GOC:obol] +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0060696 ! regulation of phospholipid catabolic process +is_a: GO:1905038 ! regulation of membrane lipid metabolic process +relationship: regulates GO:0006685 ! sphingomyelin catabolic process + +[Term] +id: GO:2000755 +name: positive regulation of sphingomyelin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sphingomyelin catabolic process." [GOC:BHF] +synonym: "positive regulation of sphingomyelin breakdown" EXACT [GOC:obol] +synonym: "positive regulation of sphingomyelin catabolism" EXACT [GOC:obol] +synonym: "positive regulation of sphingomyelin degradation" EXACT [GOC:obol] +is_a: GO:0034250 ! positive regulation of cellular amide metabolic process +is_a: GO:0060697 ! positive regulation of phospholipid catabolic process +is_a: GO:2000754 ! regulation of sphingomyelin catabolic process +relationship: positively_regulates GO:0006685 ! sphingomyelin catabolic process + +[Term] +id: GO:2000756 +name: regulation of peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1901983 ! regulation of protein acetylation +relationship: regulates GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:2000757 +name: negative regulation of peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1901984 ! negative regulation of protein acetylation +is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation +relationship: negatively_regulates GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:2000758 +name: positive regulation of peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1901985 ! positive regulation of protein acetylation +is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation +relationship: positively_regulates GO:0018394 ! peptidyl-lysine acetylation + +[Term] +id: GO:2000759 +name: regulation of N-terminal peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1903317 ! regulation of protein maturation +is_a: GO:2000756 ! regulation of peptidyl-lysine acetylation +relationship: regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation + +[Term] +id: GO:2000760 +name: negative regulation of N-terminal peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1903318 ! negative regulation of protein maturation +is_a: GO:2000757 ! negative regulation of peptidyl-lysine acetylation +is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation +relationship: negatively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation + +[Term] +id: GO:2000761 +name: positive regulation of N-terminal peptidyl-lysine acetylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of N-terminal peptidyl-lysine acetylation." [GOC:obol] +is_a: GO:1903319 ! positive regulation of protein maturation +is_a: GO:2000758 ! positive regulation of peptidyl-lysine acetylation +is_a: GO:2000759 ! regulation of N-terminal peptidyl-lysine acetylation +relationship: positively_regulates GO:0018076 ! N-terminal peptidyl-lysine acetylation + +[Term] +id: GO:2000762 +name: regulation of phenylpropanoid metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phenylpropanoid metabolic process." [GOC:obol] +synonym: "regulation of phenylpropanoid metabolism" EXACT [GOC:obol] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0043455 ! regulation of secondary metabolic process +relationship: regulates GO:0009698 ! phenylpropanoid metabolic process + +[Term] +id: GO:2000763 +name: positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process +namespace: biological_process +def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in norepinephrine biosynthetic process." [GOC:BHF] +synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in levarterenol biosynthetic process" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine anabolism" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine biosynthetic process" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine formation" EXACT [GOC:obol] +synonym: "positive regulation of transcription from Pol II promoter involved in norepinephrine synthesis" EXACT [GOC:obol] +is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II +relationship: part_of GO:0042421 ! norepinephrine biosynthetic process + +[Term] +id: GO:2000764 +name: positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis." [GOC:BHF] +synonym: "positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis" EXACT [GOC:obol] +is_a: GO:2001262 ! positive regulation of semaphorin-plexin signaling pathway +relationship: positively_regulates GO:0071527 ! semaphorin-plexin signaling pathway involved in outflow tract morphogenesis + +[Term] +id: GO:2000765 +name: regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0006417 ! regulation of translation +relationship: regulates GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:2000766 +name: negative regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:2000765 ! regulation of cytoplasmic translation +relationship: negatively_regulates GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:2000767 +name: positive regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:2000765 ! regulation of cytoplasmic translation +relationship: positively_regulates GO:0002181 ! cytoplasmic translation + +[Term] +id: GO:2000768 +name: positive regulation of nephron tubule epithelial cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation." [GOC:obol] +is_a: GO:0072182 ! regulation of nephron tubule epithelial cell differentiation +is_a: GO:2000698 ! positive regulation of epithelial cell differentiation involved in kidney development +relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell differentiation + +[Term] +id: GO:2000769 +name: regulation of establishment or maintenance of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] +is_a: GO:0008360 ! regulation of cell shape +is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity +relationship: regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:2000770 +name: negative regulation of establishment or maintenance of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: negatively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:2000771 +name: positive regulation of establishment or maintenance of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of cell polarity regulating cell shape." [GOC:mah] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: positively_regulates GO:0071963 ! establishment or maintenance of cell polarity regulating cell shape + +[Term] +id: GO:2000772 +name: regulation of cellular senescence +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0080135 ! regulation of cellular response to stress +is_a: GO:0090342 ! regulation of cell aging +relationship: regulates GO:0090398 ! cellular senescence + +[Term] +id: GO:2000773 +name: negative regulation of cellular senescence +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:0090344 ! negative regulation of cell aging +is_a: GO:2000772 ! regulation of cellular senescence +relationship: negatively_regulates GO:0090398 ! cellular senescence + +[Term] +id: GO:2000774 +name: positive regulation of cellular senescence +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular senescence." [GOC:BHF] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:0090343 ! positive regulation of cell aging +is_a: GO:2000772 ! regulation of cellular senescence +relationship: positively_regulates GO:0090398 ! cellular senescence + +[Term] +id: GO:2000775 +name: obsolete histone H3-S10 phosphorylation involved in chromosome condensation +namespace: biological_process +def: "OBSOLETE. Any histone H3-S10 phosphorylation that is involved in chromosome condensation." [GOC:obol] +comment: This term was obsoleted because it is a molecular function represented as a biological process. +synonym: "histone H3 phosphorylation at S10 of chromosome condensation" EXACT [GOC:obol] +synonym: "histone H3-S10 phosphorylation of chromosome condensation" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2000776 +name: histone H4 acetylation involved in response to DNA damage stimulus +namespace: biological_process +def: "Any histone H4 acetylation that is involved in a response to DNA damage stimulus." [GOC:mah] +synonym: "histone H4 acetylation of cellular DNA damage response" EXACT [GOC:obol] +synonym: "histone H4 acetylation of cellular response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "histone H4 acetylation of DNA damage response" EXACT [GOC:obol] +synonym: "histone H4 acetylation of response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "histone H4 acetylation of response to genotoxic stress" EXACT [GOC:obol] +is_a: GO:0043967 ! histone H4 acetylation +relationship: part_of GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:2000777 +name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia +namespace: biological_process +def: "Any positive regulation of proteasomal ubiquitin-dependent protein catabolic process that is involved in a cellular response to hypoxia." [GOC:mah] +synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxic stress" EXACT [GOC:obol] +synonym: "positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to lowered oxygen tension" EXACT [GOC:obol] +is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process +relationship: part_of GO:0071456 ! cellular response to hypoxia + +[Term] +id: GO:2000779 +name: regulation of double-strand break repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of double-strand break repair." [GOC:BHF] +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0006302 ! double-strand break repair + +[Term] +id: GO:2000780 +name: negative regulation of double-strand break repair +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair." [GOC:BHF] +is_a: GO:0045738 ! negative regulation of DNA repair +is_a: GO:2000779 ! regulation of double-strand break repair +relationship: negatively_regulates GO:0006302 ! double-strand break repair + +[Term] +id: GO:2000781 +name: positive regulation of double-strand break repair +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair." [GOC:BHF] +is_a: GO:0045739 ! positive regulation of DNA repair +is_a: GO:2000779 ! regulation of double-strand break repair +relationship: positively_regulates GO:0006302 ! double-strand break repair + +[Term] +id: GO:2000782 +name: regulation of establishment of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] +is_a: GO:2000114 ! regulation of establishment of cell polarity +is_a: GO:2000769 ! regulation of establishment or maintenance of cell polarity regulating cell shape +relationship: regulates GO:0071964 ! establishment of cell polarity regulating cell shape + +[Term] +id: GO:2000783 +name: negative regulation of establishment of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] +is_a: GO:2000770 ! negative regulation of establishment or maintenance of cell polarity regulating cell shape +is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape +relationship: negatively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape + +[Term] +id: GO:2000784 +name: positive regulation of establishment of cell polarity regulating cell shape +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of establishment of cell polarity regulating cell shape." [GOC:Mah] +is_a: GO:2000771 ! positive regulation of establishment or maintenance of cell polarity regulating cell shape +is_a: GO:2000782 ! regulation of establishment of cell polarity regulating cell shape +relationship: positively_regulates GO:0071964 ! establishment of cell polarity regulating cell shape + +[Term] +id: GO:2000785 +name: regulation of autophagosome assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF] +synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] +synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol] +synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol] +synonym: "regulation of autophagosome formation" EXACT [GOC:obol] +synonym: "regulation of PAS formation" RELATED [GOC:obol] +is_a: GO:0044088 ! regulation of vacuole organization +is_a: GO:1902115 ! regulation of organelle assembly +relationship: regulates GO:0000045 ! autophagosome assembly + +[Term] +id: GO:2000786 +name: positive regulation of autophagosome assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF] +synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] +synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol] +synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol] +synonym: "positive regulation of PAS formation" RELATED [GOC:obol] +is_a: GO:0016239 ! positive regulation of macroautophagy +is_a: GO:0044090 ! positive regulation of vacuole organization +is_a: GO:1902117 ! positive regulation of organelle assembly +is_a: GO:2000785 ! regulation of autophagosome assembly +relationship: positively_regulates GO:0000045 ! autophagosome assembly + +[Term] +id: GO:2000787 +name: regulation of venous endothelial cell fate commitment +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] +is_a: GO:0010453 ! regulation of cell fate commitment +is_a: GO:0110057 ! regulation of blood vessel endothelial cell differentiation +relationship: regulates GO:0060845 ! venous endothelial cell fate commitment + +[Term] +id: GO:2000788 +name: negative regulation of venous endothelial cell fate commitment +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] +is_a: GO:0010454 ! negative regulation of cell fate commitment +is_a: GO:0110059 ! negative regulation of blood vessel endothelial cell differentiation +is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment +relationship: negatively_regulates GO:0060845 ! venous endothelial cell fate commitment + +[Term] +id: GO:2000789 +name: positive regulation of venous endothelial cell fate commitment +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment." [PMID:11585794] +is_a: GO:0010455 ! positive regulation of cell fate commitment +is_a: GO:0110058 ! positive regulation of blood vessel endothelial cell differentiation +is_a: GO:2000787 ! regulation of venous endothelial cell fate commitment +relationship: positively_regulates GO:0060845 ! venous endothelial cell fate commitment + +[Term] +id: GO:2000790 +name: regulation of mesenchymal cell proliferation involved in lung development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] +is_a: GO:0010464 ! regulation of mesenchymal cell proliferation +relationship: regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development + +[Term] +id: GO:2000791 +name: negative regulation of mesenchymal cell proliferation involved in lung development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:0072201 ! negative regulation of mesenchymal cell proliferation +is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development +relationship: negatively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development + +[Term] +id: GO:2000792 +name: positive regulation of mesenchymal cell proliferation involved in lung development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development." [PMID:21513708] +is_a: GO:0002053 ! positive regulation of mesenchymal cell proliferation +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000790 ! regulation of mesenchymal cell proliferation involved in lung development +relationship: positively_regulates GO:0060916 ! mesenchymal cell proliferation involved in lung development + +[Term] +id: GO:2000793 +name: cell proliferation involved in heart valve development +namespace: biological_process +def: "Any cell proliferation that is involved in heart valve development." [GOC:BHF] +synonym: "cell proliferation of cardiac valve development" EXACT [GOC:obol] +synonym: "cell proliferation of heart valve development" EXACT [GOC:obol] +is_a: GO:0008283 ! cell population proliferation +relationship: part_of GO:0003170 ! heart valve development + +[Term] +id: GO:2000794 +name: regulation of epithelial cell proliferation involved in lung morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis + +[Term] +id: GO:2000795 +name: negative regulation of epithelial cell proliferation involved in lung morphogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis." [PMID:21513708] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:2000794 ! regulation of epithelial cell proliferation involved in lung morphogenesis +relationship: negatively_regulates GO:0060502 ! epithelial cell proliferation involved in lung morphogenesis + +[Term] +id: GO:2000796 +name: Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment +namespace: biological_process +def: "Any Notch signaling pathway that is involved in negative regulation of venous endothelial cell fate commitment." [PMID:11585794] +synonym: "N signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +synonym: "Notch receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +synonym: "Notch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +synonym: "Notch signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +synonym: "Notch-receptor signaling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +synonym: "Notch-receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment" EXACT [GOC:obol] +is_a: GO:0007219 ! Notch signaling pathway +relationship: part_of GO:2000788 ! negative regulation of venous endothelial cell fate commitment + +[Term] +id: GO:2000797 +name: regulation of amniotic stem cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] +is_a: GO:2000739 ! regulation of mesenchymal stem cell differentiation +relationship: regulates GO:0097086 ! amniotic stem cell differentiation + +[Term] +id: GO:2000798 +name: negative regulation of amniotic stem cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] +is_a: GO:2000740 ! negative regulation of mesenchymal stem cell differentiation +is_a: GO:2000797 ! regulation of amniotic stem cell differentiation +relationship: negatively_regulates GO:0097086 ! amniotic stem cell differentiation + +[Term] +id: GO:2000799 +name: positive regulation of amniotic stem cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amniotic stem cell differentiation." [GOC:obol] +is_a: GO:2000741 ! positive regulation of mesenchymal stem cell differentiation +is_a: GO:2000797 ! regulation of amniotic stem cell differentiation +relationship: positively_regulates GO:0097086 ! amniotic stem cell differentiation + +[Term] +id: GO:2000800 +name: regulation of endocardial cushion to mesenchymal transition involved in heart valve formation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] +synonym: "regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] +is_a: GO:0140049 ! regulation of endocardial cushion to mesenchymal transition +relationship: regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation + +[Term] +id: GO:2000801 +name: negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] +synonym: "negative regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] +is_a: GO:0140050 ! negative regulation of endocardial cushion to mesenchymal transition +is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation +relationship: negatively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation + +[Term] +id: GO:2000802 +name: positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocardial cushion to mesenchymal transition involved in heart valve formation." [GOC:BHF] +synonym: "positive regulation of endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:obol] +is_a: GO:0140051 ! positive regulation of endocardial cushion to mesenchymal transition +is_a: GO:2000800 ! regulation of endocardial cushion to mesenchymal transition involved in heart valve formation +relationship: positively_regulates GO:0003199 ! endocardial cushion to mesenchymal transition involved in heart valve formation + +[Term] +id: GO:2000803 +name: endosomal signal transduction +namespace: biological_process +def: "The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction." [GOC:bf, GOC:signaling, PMID:15084302, PMID:17662591] +synonym: "endosome-based signaling" EXACT [PMID:17662591] +synonym: "signaling cascade in endosome" RELATED [GOC:obol] +synonym: "signaling from endosome" EXACT [PMID:17662591] +synonym: "signaling pathway in endosome" RELATED [GOC:obol] +synonym: "signalling cascade in endosome" RELATED [GOC:obol] +synonym: "signalling pathway in endosome" RELATED [GOC:obol] +is_a: GO:0035556 ! intracellular signal transduction + +[Term] +id: GO:2000804 +name: regulation of termination of RNA polymerase II transcription, poly(A)-coupled +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] +synonym: "regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] +synonym: "regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] +synonym: "regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] +is_a: GO:1904594 ! regulation of termination of RNA polymerase II transcription +relationship: regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled + +[Term] +id: GO:2000805 +name: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] +synonym: "negative regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] +synonym: "negative regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] +synonym: "negative regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] +is_a: GO:0120191 ! negative regulation of termination of RNA polymerase II transcription +is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled +relationship: negatively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled + +[Term] +id: GO:2000806 +name: positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription, poly(A)-coupled." [GOC:obol] +synonym: "positive regulation of termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] +synonym: "positive regulation of transcription termination from Pol II promoter, poly(A) coupled" RELATED [GOC:obol] +synonym: "positive regulation of transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [GOC:obol] +is_a: GO:1904595 ! positive regulation of termination of RNA polymerase II transcription +is_a: GO:2000804 ! regulation of termination of RNA polymerase II transcription, poly(A)-coupled +relationship: positively_regulates GO:0030846 ! termination of RNA polymerase II transcription, poly(A)-coupled + +[Term] +id: GO:2000807 +name: regulation of synaptic vesicle clustering +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] +is_a: GO:0060341 ! regulation of cellular localization +relationship: regulates GO:0097091 ! synaptic vesicle clustering + +[Term] +id: GO:2000808 +name: negative regulation of synaptic vesicle clustering +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:2000807 ! regulation of synaptic vesicle clustering +relationship: negatively_regulates GO:0097091 ! synaptic vesicle clustering + +[Term] +id: GO:2000809 +name: positive regulation of synaptic vesicle clustering +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering." [PMID:21513708] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:2000807 ! regulation of synaptic vesicle clustering +relationship: positively_regulates GO:0097091 ! synaptic vesicle clustering + +[Term] +id: GO:2000810 +name: regulation of bicellular tight junction assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tight junction assembly." [GOC:BHF] +synonym: "regulation of tight junction formation" EXACT [GOC:obol] +is_a: GO:1901888 ! regulation of cell junction assembly +relationship: regulates GO:0070830 ! bicellular tight junction assembly + +[Term] +id: GO:2000811 +name: negative regulation of anoikis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anoikis." [GOC:obol] +synonym: "negative regulation of detachment induced cell death" EXACT [GOC:obol] +synonym: "negative regulation of suspension induced apoptosis" EXACT [GOC:obol] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:2000209 ! regulation of anoikis +relationship: negatively_regulates GO:0043276 ! anoikis + +[Term] +id: GO:2000812 +name: regulation of barbed-end actin filament capping +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] +synonym: "regulation of barbed-end actin capping activity" EXACT [GOC:obol] +synonym: "regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] +synonym: "regulation of plus-end actin filament capping activity" EXACT [GOC:obol] +synonym: "regulation of plus-end F-actin capping activity" EXACT [GOC:obol] +is_a: GO:0030833 ! regulation of actin filament polymerization +is_a: GO:0030834 ! regulation of actin filament depolymerization +relationship: regulates GO:0051016 ! barbed-end actin filament capping + +[Term] +id: GO:2000813 +name: negative regulation of barbed-end actin filament capping +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] +synonym: "negative regulation of barbed-end actin capping activity" EXACT [GOC:obol] +synonym: "negative regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] +synonym: "negative regulation of plus-end actin filament capping activity" EXACT [GOC:obol] +synonym: "negative regulation of plus-end F-actin capping activity" EXACT [GOC:obol] +is_a: GO:0030836 ! positive regulation of actin filament depolymerization +is_a: GO:0030838 ! positive regulation of actin filament polymerization +is_a: GO:0051129 ! negative regulation of cellular component organization +is_a: GO:2000812 ! regulation of barbed-end actin filament capping +relationship: negatively_regulates GO:0051016 ! barbed-end actin filament capping + +[Term] +id: GO:2000814 +name: positive regulation of barbed-end actin filament capping +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of barbed-end actin filament capping." [GOC:BHF] +synonym: "positive regulation of barbed-end actin capping activity" EXACT [GOC:obol] +synonym: "positive regulation of barbed-end F-actin capping activity" EXACT [GOC:obol] +synonym: "positive regulation of plus-end actin filament capping activity" EXACT [GOC:obol] +synonym: "positive regulation of plus-end F-actin capping activity" EXACT [GOC:obol] +is_a: GO:0051130 ! positive regulation of cellular component organization +is_a: GO:2000812 ! regulation of barbed-end actin filament capping +relationship: positively_regulates GO:0051016 ! barbed-end actin filament capping + +[Term] +id: GO:2000815 +name: regulation of mRNA stability involved in response to oxidative stress +namespace: biological_process +def: "A process of regulation of mRNA stability that is involved in a response to oxidative stress." [GOC:obol] +is_a: GO:0010610 ! regulation of mRNA stability involved in response to stress +relationship: part_of GO:0006979 ! response to oxidative stress + +[Term] +id: GO:2000816 +name: negative regulation of mitotic sister chromatid separation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation." [GOC:obol] +synonym: "negative regulation of chromosome separation during mitosis" RELATED [GOC:obol] +synonym: "negative regulation of mitotic chromosome separation" RELATED [GOC:obol] +synonym: "negative regulation of mitotic sister chromatid resolution" EXACT [GOC:obol] +synonym: "negative regulation of sister chromatid separation during mitosis" EXACT [GOC:obol] +is_a: GO:0010965 ! regulation of mitotic sister chromatid separation +is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation +is_a: GO:1905819 ! negative regulation of chromosome separation +relationship: negatively_regulates GO:0051306 ! mitotic sister chromatid separation + +[Term] +id: GO:2000817 +name: regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore +namespace: biological_process +def: "Any regulation of histone H3-T3 phosphorylation that is involved in chromosome passenger complex localization to kinetochore." [GOC:obol] +synonym: "regulation of histone H3-T3 phosphorylation involved in chromosomal passenger complex localization to kinetochore" EXACT [GOC:obol] +synonym: "regulation of histone H3-T3 phosphorylation involved in chromosome passenger complex localisation to kinetochore" RELATED [GOC:obol] +synonym: "regulation of histone H3-T3 phosphorylation involved in CPC complex localization to kinetochore" EXACT [GOC:obol] +synonym: "regulation of histone H3-T3 phosphorylation involved in CPC localization to kinetochore" EXACT [GOC:obol] +is_a: GO:2000281 ! regulation of histone H3-T3 phosphorylation +relationship: part_of GO:0072356 ! chromosome passenger complex localization to kinetochore + +[Term] +id: GO:2000818 +name: negative regulation of myoblast proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation." [GOC:obol] +is_a: GO:0008285 ! negative regulation of cell population proliferation +is_a: GO:2000291 ! regulation of myoblast proliferation +relationship: negatively_regulates GO:0051450 ! myoblast proliferation + +[Term] +id: GO:2000819 +name: regulation of nucleotide-excision repair +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of nucleotide-excision repair." [GOC:jp, PMID:18836076] +synonym: "regulation of interstrand crosslink repair" RELATED [GOC:obol] +synonym: "regulation of intrastrand cross-link repair" RELATED [GOC:obol] +synonym: "regulation of NER" EXACT [GOC:obol] +synonym: "regulation of pyrimidine-dimer repair, DNA damage excision" EXACT [GOC:obol] +is_a: GO:0006282 ! regulation of DNA repair +relationship: regulates GO:0006289 ! nucleotide-excision repair + +[Term] +id: GO:2000820 +name: negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation +namespace: biological_process +def: "Any negative regulation of transcription from RNA polymerase II promoter that is involved in smooth muscle cell differentiation." [GOC:BHF] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "down regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "down regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "down-regulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "down-regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "downregulation of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "downregulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "inhibition of global transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "inhibition of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "negative regulation of global transcription from Pol II promoter involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "negative regulation of global transcription from Pol II promoter involved in smooth muscle cell differentiation" RELATED [GOC:obol] +synonym: "negative regulation of transcription from Pol II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "negative regulation of transcription from Pol II promoter involved in smooth muscle cell differentiation" EXACT [GOC:obol] +synonym: "negative regulation of transcription from RNA polymerase II promoter involved in nonstriated muscle cell differentiation" EXACT [GOC:obol] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in nonstriated muscle cell differentiation" RELATED [GOC:obol] +synonym: "negative regulation of transcription from RNA polymerase II promoter, global involved in smooth muscle cell differentiation" RELATED [GOC:obol] +is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II +relationship: part_of GO:0051145 ! smooth muscle cell differentiation + +[Term] +id: GO:2000821 +name: regulation of grooming behavior +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of grooming behavior." [GOC:BHF] +synonym: "regulation of grooming behaviour" EXACT [GOC:obol] +is_a: GO:0050795 ! regulation of behavior +relationship: regulates GO:0007625 ! grooming behavior + +[Term] +id: GO:2000822 +name: regulation of behavioral fear response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of behavioral fear response." [GOC:BHF] +synonym: "regulation of behavioural fear response" EXACT [GOC:obol] +is_a: GO:0031347 ! regulation of defense response +is_a: GO:0050795 ! regulation of behavior +is_a: GO:1903365 ! regulation of fear response +relationship: regulates GO:0001662 ! behavioral fear response + +[Term] +id: GO:2000825 +name: positive regulation of androgen receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of androgen receptor activity." [GOC:obol] +is_a: GO:0006357 ! regulation of transcription by RNA polymerase II +is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity +is_a: GO:2000273 ! positive regulation of signaling receptor activity + +[Term] +id: GO:2000826 +name: regulation of heart morphogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of heart morphogenesis." [GOC:BHF] +synonym: "regulation of cardiac morphogenesis" RELATED [GOC:obol] +is_a: GO:2000027 ! regulation of animal organ morphogenesis +relationship: regulates GO:0003007 ! heart morphogenesis + +[Term] +id: GO:2000827 +name: mitochondrial RNA surveillance +namespace: biological_process +def: "The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion." [PMID:19864255] +synonym: "aberrant RNA catabolic process in mitochondria" EXACT [GOC:obol] +synonym: "aberrant RNA catabolic process in mitochondrion" EXACT [GOC:obol] +synonym: "RNA quality control in mitochondria" EXACT [GOC:obol] +synonym: "RNA quality control in mitochondrion" EXACT [GOC:obol] +synonym: "RNA surveillance in mitochondria" EXACT [GOC:obol] +is_a: GO:0000957 ! mitochondrial RNA catabolic process +is_a: GO:0071026 ! cytoplasmic RNA surveillance + +[Term] +id: GO:2000828 +name: regulation of parathyroid hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] +synonym: "regulation of parathormone secretion" EXACT [GOC:obol] +synonym: "regulation of parathyrin secretion" EXACT [GOC:obol] +synonym: "regulation of PTH secretion" EXACT [GOC:obol] +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035898 ! parathyroid hormone secretion + +[Term] +id: GO:2000829 +name: negative regulation of parathyroid hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] +synonym: "negative regulation of parathormone secretion" EXACT [GOC:obol] +synonym: "negative regulation of parathyrin secretion" EXACT [GOC:obol] +synonym: "negative regulation of PTH secretion" EXACT [GOC:obol] +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000828 ! regulation of parathyroid hormone secretion +relationship: negatively_regulates GO:0035898 ! parathyroid hormone secretion + +[Term] +id: GO:2000830 +name: positive regulation of parathyroid hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion." [GOC:obol] +synonym: "positive regulation of parathormone secretion" EXACT [GOC:obol] +synonym: "positive regulation of parathyrin secretion" EXACT [GOC:obol] +synonym: "positive regulation of PTH secretion" EXACT [GOC:obol] +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000828 ! regulation of parathyroid hormone secretion +relationship: positively_regulates GO:0035898 ! parathyroid hormone secretion + +[Term] +id: GO:2000831 +name: regulation of steroid hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of steroid hormone secretion." [GOC:sl] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0044060 ! regulation of endocrine process +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:2000832 +name: negative regulation of steroid hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion." [GOC:sl] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: negatively_regulates GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:2000833 +name: positive regulation of steroid hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of steroid hormone secretion." [GOC:sl] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: positively_regulates GO:0035929 ! steroid hormone secretion + +[Term] +id: GO:2000834 +name: regulation of androgen secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of androgen secretion." [GOC:sl] +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: regulates GO:0035935 ! androgen secretion + +[Term] +id: GO:2000835 +name: negative regulation of androgen secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion." [GOC:sl] +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +is_a: GO:2000834 ! regulation of androgen secretion +relationship: negatively_regulates GO:0035935 ! androgen secretion + +[Term] +id: GO:2000836 +name: positive regulation of androgen secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of androgen secretion." [GOC:sl] +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +is_a: GO:2000834 ! regulation of androgen secretion +relationship: positively_regulates GO:0035935 ! androgen secretion + +[Term] +id: GO:2000837 +name: regulation of androstenedione secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of androstenedione secretion." [GOC:sl] +synonym: "regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035941 ! androstenedione secretion + +[Term] +id: GO:2000838 +name: negative regulation of androstenedione secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of androstenedione secretion." [GOC:sl] +synonym: "negative regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000837 ! regulation of androstenedione secretion +relationship: negatively_regulates GO:0035941 ! androstenedione secretion + +[Term] +id: GO:2000839 +name: positive regulation of androstenedione secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of androstenedione secretion." [GOC:sl] +synonym: "positive regulation of androst-4-ene-3,17-dione secretion" EXACT [GOC:obol] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000837 ! regulation of androstenedione secretion +relationship: positively_regulates GO:0035941 ! androstenedione secretion + +[Term] +id: GO:2000840 +name: regulation of dehydroepiandrosterone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] +synonym: "regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] +synonym: "regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] +synonym: "regulation of DHEA secretion" EXACT [GOC:obol] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035942 ! dehydroepiandrosterone secretion + +[Term] +id: GO:2000841 +name: negative regulation of dehydroepiandrosterone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] +synonym: "negative regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] +synonym: "negative regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] +synonym: "negative regulation of DHEA secretion" EXACT [GOC:obol] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion +relationship: negatively_regulates GO:0035942 ! dehydroepiandrosterone secretion + +[Term] +id: GO:2000842 +name: positive regulation of dehydroepiandrosterone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dehydroepiandrosterone secretion." [GOC:sl] +synonym: "positive regulation of 3beta-hydroxyandrost-5-en-17-one secretion" EXACT [GOC:obol] +synonym: "positive regulation of dehydroisoandrosterone secretion" EXACT [GOC:obol] +synonym: "positive regulation of DHEA secretion" EXACT [GOC:obol] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000840 ! regulation of dehydroepiandrosterone secretion +relationship: positively_regulates GO:0035942 ! dehydroepiandrosterone secretion + +[Term] +id: GO:2000843 +name: regulation of testosterone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of testosterone secretion." [GOC:sl] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035936 ! testosterone secretion + +[Term] +id: GO:2000844 +name: negative regulation of testosterone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of testosterone secretion." [GOC:sl] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000843 ! regulation of testosterone secretion +relationship: negatively_regulates GO:0035936 ! testosterone secretion + +[Term] +id: GO:2000845 +name: positive regulation of testosterone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of testosterone secretion." [GOC:sl] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000843 ! regulation of testosterone secretion +relationship: positively_regulates GO:0035936 ! testosterone secretion + +[Term] +id: GO:2000846 +name: regulation of corticosteroid hormone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] +synonym: "regulation of corticosteroid secretion" RELATED [GOC:obol] +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: regulates GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:2000847 +name: negative regulation of corticosteroid hormone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] +synonym: "negative regulation of corticosteroid secretion" RELATED [GOC:obol] +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +is_a: GO:2000846 ! regulation of corticosteroid hormone secretion +relationship: negatively_regulates GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:2000848 +name: positive regulation of corticosteroid hormone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion." [GOC:sl] +synonym: "positive regulation of corticosteroid secretion" RELATED [GOC:obol] +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +is_a: GO:2000846 ! regulation of corticosteroid hormone secretion +relationship: positively_regulates GO:0035930 ! corticosteroid hormone secretion + +[Term] +id: GO:2000849 +name: regulation of glucocorticoid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] +is_a: GO:2000846 ! regulation of corticosteroid hormone secretion +relationship: regulates GO:0035933 ! glucocorticoid secretion + +[Term] +id: GO:2000850 +name: negative regulation of glucocorticoid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] +is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion +is_a: GO:2000849 ! regulation of glucocorticoid secretion +relationship: negatively_regulates GO:0035933 ! glucocorticoid secretion + +[Term] +id: GO:2000851 +name: positive regulation of glucocorticoid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucocorticoid secretion." [GOC:sl] +is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion +is_a: GO:2000849 ! regulation of glucocorticoid secretion +relationship: positively_regulates GO:0035933 ! glucocorticoid secretion + +[Term] +id: GO:2000852 +name: regulation of corticosterone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of corticosterone secretion." [GOC:sl] +is_a: GO:2000849 ! regulation of glucocorticoid secretion +relationship: regulates GO:0035934 ! corticosterone secretion + +[Term] +id: GO:2000853 +name: negative regulation of corticosterone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion." [GOC:sl] +is_a: GO:2000850 ! negative regulation of glucocorticoid secretion +is_a: GO:2000852 ! regulation of corticosterone secretion +relationship: negatively_regulates GO:0035934 ! corticosterone secretion + +[Term] +id: GO:2000854 +name: positive regulation of corticosterone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of corticosterone secretion." [GOC:sl] +is_a: GO:2000851 ! positive regulation of glucocorticoid secretion +is_a: GO:2000852 ! regulation of corticosterone secretion +relationship: positively_regulates GO:0035934 ! corticosterone secretion + +[Term] +id: GO:2000855 +name: regulation of mineralocorticoid secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] +is_a: GO:2000846 ! regulation of corticosteroid hormone secretion +relationship: regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000856 +name: negative regulation of mineralocorticoid secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] +is_a: GO:2000847 ! negative regulation of corticosteroid hormone secretion +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +relationship: negatively_regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000857 +name: positive regulation of mineralocorticoid secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion." [GOC:sl] +is_a: GO:2000848 ! positive regulation of corticosteroid hormone secretion +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +relationship: positively_regulates GO:0035931 ! mineralocorticoid secretion + +[Term] +id: GO:2000858 +name: regulation of aldosterone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of aldosterone secretion." [GOC:sl] +is_a: GO:2000855 ! regulation of mineralocorticoid secretion +relationship: regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000859 +name: negative regulation of aldosterone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion." [GOC:sl] +is_a: GO:2000856 ! negative regulation of mineralocorticoid secretion +is_a: GO:2000858 ! regulation of aldosterone secretion +relationship: negatively_regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000860 +name: positive regulation of aldosterone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of aldosterone secretion." [GOC:sl] +is_a: GO:2000857 ! positive regulation of mineralocorticoid secretion +is_a: GO:2000858 ! regulation of aldosterone secretion +relationship: positively_regulates GO:0035932 ! aldosterone secretion + +[Term] +id: GO:2000861 +name: regulation of estrogen secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of estrogen secretion." [GOC:sl] +synonym: "regulation of oestrogen secretion" RELATED [GOC:obol] +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: regulates GO:0035937 ! estrogen secretion + +[Term] +id: GO:2000862 +name: negative regulation of estrogen secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrogen secretion." [GOC:sl] +synonym: "negative regulation of oestrogen secretion" RELATED [GOC:obol] +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +is_a: GO:2000861 ! regulation of estrogen secretion +relationship: negatively_regulates GO:0035937 ! estrogen secretion + +[Term] +id: GO:2000863 +name: positive regulation of estrogen secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of estrogen secretion." [GOC:sl] +synonym: "positive regulation of oestrogen secretion" RELATED [GOC:obol] +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +is_a: GO:2000861 ! regulation of estrogen secretion +relationship: positively_regulates GO:0035937 ! estrogen secretion + +[Term] +id: GO:2000864 +name: regulation of estradiol secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of estradiol secretion." [GOC:sl] +synonym: "regulation of oestradiol secretion" EXACT [GOC:obol] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035938 ! estradiol secretion + +[Term] +id: GO:2000865 +name: negative regulation of estradiol secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of estradiol secretion." [GOC:sl] +synonym: "negative regulation of oestradiol secretion" EXACT [GOC:obol] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000864 ! regulation of estradiol secretion +relationship: negatively_regulates GO:0035938 ! estradiol secretion + +[Term] +id: GO:2000866 +name: positive regulation of estradiol secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of estradiol secretion." [GOC:sl] +synonym: "positive regulation of oestradiol secretion" EXACT [GOC:obol] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000864 ! regulation of estradiol secretion +relationship: positively_regulates GO:0035938 ! estradiol secretion + +[Term] +id: GO:2000867 +name: regulation of estrone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of estrone secretion." [GOC:sl] +synonym: "regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] +synonym: "regulation of folliculin secretion" EXACT [GOC:obol] +is_a: GO:0032368 ! regulation of lipid transport +is_a: GO:0046883 ! regulation of hormone secretion +relationship: regulates GO:0035943 ! estrone secretion + +[Term] +id: GO:2000868 +name: negative regulation of estrone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion." [GOC:sl] +synonym: "negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] +synonym: "negative regulation of folliculin secretion" EXACT [GOC:obol] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:0046888 ! negative regulation of hormone secretion +is_a: GO:2000867 ! regulation of estrone secretion +relationship: negatively_regulates GO:0035943 ! estrone secretion + +[Term] +id: GO:2000869 +name: positive regulation of estrone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of estrone secretion." [GOC:sl] +synonym: "positive regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion" EXACT [GOC:obol] +synonym: "positive regulation of folliculin secretion" EXACT [GOC:obol] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:0046887 ! positive regulation of hormone secretion +is_a: GO:2000867 ! regulation of estrone secretion +relationship: positively_regulates GO:0035943 ! estrone secretion + +[Term] +id: GO:2000870 +name: regulation of progesterone secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of progesterone secretion." [GOC:sl] +is_a: GO:2000194 ! regulation of female gonad development +is_a: GO:2000831 ! regulation of steroid hormone secretion +relationship: regulates GO:0042701 ! progesterone secretion + +[Term] +id: GO:2000871 +name: negative regulation of progesterone secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion." [GOC:sl] +is_a: GO:2000195 ! negative regulation of female gonad development +is_a: GO:2000832 ! negative regulation of steroid hormone secretion +is_a: GO:2000870 ! regulation of progesterone secretion +relationship: negatively_regulates GO:0042701 ! progesterone secretion + +[Term] +id: GO:2000872 +name: positive regulation of progesterone secretion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of progesterone secretion." [GOC:sl] +is_a: GO:2000196 ! positive regulation of female gonad development +is_a: GO:2000833 ! positive regulation of steroid hormone secretion +is_a: GO:2000870 ! regulation of progesterone secretion +relationship: positively_regulates GO:0042701 ! progesterone secretion + +[Term] +id: GO:2000873 +name: regulation of histone H4 acetylation involved in response to DNA damage stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus." [GOC:mah] +synonym: "regulation of histone H4 acetylation involved in cellular DNA damage response" EXACT [GOC:obol] +synonym: "regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "regulation of histone H4 acetylation involved in DNA damage response" EXACT [GOC:obol] +synonym: "regulation of histone H4 acetylation involved in response to DNA damage" EXACT [GOC:bf] +synonym: "regulation of histone H4 acetylation involved in response to genotoxic stress" EXACT [GOC:obol] +is_a: GO:0090239 ! regulation of histone H4 acetylation +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: regulates GO:2000776 ! histone H4 acetylation involved in response to DNA damage stimulus + +[Term] +id: GO:2000874 +name: regulation of glyoxylate cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] +synonym: "regulation of glyoxylate bypass" EXACT [GOC:obol] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +relationship: regulates GO:0006097 ! glyoxylate cycle + +[Term] +id: GO:2000875 +name: negative regulation of glyoxylate cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] +synonym: "negative regulation of glyoxylate bypass" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:2000874 ! regulation of glyoxylate cycle +relationship: negatively_regulates GO:0006097 ! glyoxylate cycle + +[Term] +id: GO:2000876 +name: positive regulation of glyoxylate cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glyoxylate cycle." [GOC:dgf] +synonym: "positive regulation of glyoxylate bypass" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:2000874 ! regulation of glyoxylate cycle +relationship: positively_regulates GO:0006097 ! glyoxylate cycle + +[Term] +id: GO:2000877 +name: negative regulation of oligopeptide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport." [GOC:obol] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0090088 ! regulation of oligopeptide transport +relationship: negatively_regulates GO:0006857 ! oligopeptide transport + +[Term] +id: GO:2000878 +name: positive regulation of oligopeptide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of oligopeptide transport." [GOC:obol] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0090088 ! regulation of oligopeptide transport +relationship: positively_regulates GO:0006857 ! oligopeptide transport + +[Term] +id: GO:2000879 +name: negative regulation of dipeptide transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport." [GOC:obol] +is_a: GO:0090089 ! regulation of dipeptide transport +is_a: GO:2000877 ! negative regulation of oligopeptide transport +relationship: negatively_regulates GO:0042938 ! dipeptide transport + +[Term] +id: GO:2000880 +name: positive regulation of dipeptide transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dipeptide transport." [GOC:obol] +is_a: GO:0090089 ! regulation of dipeptide transport +is_a: GO:2000878 ! positive regulation of oligopeptide transport +relationship: positively_regulates GO:0042938 ! dipeptide transport + +[Term] +id: GO:2000881 +name: regulation of starch catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of starch catabolic process." [GOC:obol] +synonym: "regulation of starch breakdown" EXACT [GOC:obol] +synonym: "regulation of starch catabolism" EXACT [GOC:obol] +synonym: "regulation of starch degradation" EXACT [GOC:obol] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:2000904 ! regulation of starch metabolic process +relationship: regulates GO:0005983 ! starch catabolic process + +[Term] +id: GO:2000882 +name: negative regulation of starch catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process." [GOC:obol] +synonym: "negative regulation of starch breakdown" EXACT [GOC:obol] +synonym: "negative regulation of starch catabolism" EXACT [GOC:obol] +synonym: "negative regulation of starch degradation" EXACT [GOC:obol] +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:2000881 ! regulation of starch catabolic process +is_a: GO:2000905 ! negative regulation of starch metabolic process +relationship: negatively_regulates GO:0005983 ! starch catabolic process + +[Term] +id: GO:2000883 +name: positive regulation of starch catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of starch catabolic process." [GOC:obol] +synonym: "positive regulation of starch breakdown" EXACT [GOC:obol] +synonym: "positive regulation of starch catabolism" EXACT [GOC:obol] +synonym: "positive regulation of starch degradation" EXACT [GOC:obol] +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:2000881 ! regulation of starch catabolic process +is_a: GO:2000906 ! positive regulation of starch metabolic process +relationship: positively_regulates GO:0005983 ! starch catabolic process + +[Term] +id: GO:2000884 +name: glucomannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a glucomannan." [GOC:mengo_curators] +synonym: "glucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0010391 ! glucomannan metabolic process + +[Term] +id: GO:2000885 +name: galactoglucomannan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a galactoglucomannan." [GOC:mengo_curators] +synonym: "galactoglucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0000272 ! polysaccharide catabolic process +is_a: GO:0010392 ! galactoglucomannan metabolic process + +[Term] +id: GO:2000886 +name: glucuronoxylan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoxylan." [GOC:mengo_curators] +synonym: "glucuronoxylan catabolism" EXACT [GOC:obol] +is_a: GO:0010413 ! glucuronoxylan metabolic process +is_a: GO:0045493 ! xylan catabolic process + +[Term] +id: GO:2000887 +name: glucuronoarabinoxylan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a glucuronoarabinoxylan." [GOC:mengo_curators] +synonym: "glucuronoarabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:0010414 ! glucuronoarabinoxylan metabolic process +is_a: GO:2000886 ! glucuronoxylan catabolic process +is_a: GO:2000888 ! arabinoxylan-containing compound catabolic process + +[Term] +id: GO:2000888 +name: arabinoxylan-containing compound catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an arabinoxylan." [GOC:mengo_curators] +synonym: "arabinoxylan catabolic process" RELATED [] +synonym: "arabinoxylan catabolism" RELATED [GOC:obol] +is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process +is_a: GO:0045493 ! xylan catabolic process + +[Term] +id: GO:2000889 +name: cellodextrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cellodextrin." [GOC:obol] +synonym: "cellodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044042 ! glucan metabolic process + +[Term] +id: GO:2000890 +name: cellodextrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cellodextrin." [GOC:mengo_curators] +synonym: "cellodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:2000889 ! cellodextrin metabolic process + +[Term] +id: GO:2000891 +name: cellobiose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cellobiose." [GOC:mengo_curators] +synonym: "cellobiose metabolism" EXACT [GOC:obol] +is_a: GO:0005984 ! disaccharide metabolic process + +[Term] +id: GO:2000892 +name: cellobiose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cellobiose." [GOC:mengo_curators] +synonym: "cellobiose catabolism" EXACT [GOC:obol] +is_a: GO:0046352 ! disaccharide catabolic process +is_a: GO:2000891 ! cellobiose metabolic process + +[Term] +id: GO:2000893 +name: cellotriose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cellotriose." [GOC:mengo_curators] +synonym: "cellotriose metabolism" EXACT [GOC:obol] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:2000894 +name: cellotriose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cellotriose." [GOC:mengo_curators] +synonym: "cellotriose catabolism" EXACT [GOC:obol] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:2000893 ! cellotriose metabolic process + +[Term] +id: GO:2000895 +name: hemicellulose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a hemicellulose." [GOC:mengo_curators] +synonym: "hemicellulose catabolism" EXACT [GOC:obol] +is_a: GO:0010410 ! hemicellulose metabolic process +is_a: GO:0044347 ! cell wall polysaccharide catabolic process + +[Term] +id: GO:2000896 +name: amylopectin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving an amylopectin." [GOC:mengo_curators] +synonym: "Amylopectin metabolism" EXACT [GOC:obol] +is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:2000897 +name: amylopectin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of an amylopectin." [GOC:mengo_curators] +synonym: "Amylopectin catabolism" EXACT [GOC:obol] +is_a: GO:0009057 ! macromolecule catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:2000896 ! amylopectin metabolic process + +[Term] +id: GO:2000898 +name: regulation of glucomannan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] +synonym: "regulation of glucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +relationship: regulates GO:2000884 ! glucomannan catabolic process + +[Term] +id: GO:2000899 +name: xyloglucan catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a xyloglucan." [GOC:mengo_curators] +synonym: "xyloglucan catabolism" EXACT [GOC:obol] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0010411 ! xyloglucan metabolic process +is_a: GO:2000895 ! hemicellulose catabolic process + +[Term] +id: GO:2000900 +name: cyclodextrin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cyclodextrin." [GOC:mengo_curators] +synonym: "cyclodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0009311 ! oligosaccharide metabolic process +is_a: GO:0044042 ! glucan metabolic process + +[Term] +id: GO:2000901 +name: cyclodextrin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cyclodextrin." [GOC:mengo_curators] +synonym: "cyclodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009251 ! glucan catabolic process +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:2000900 ! cyclodextrin metabolic process + +[Term] +id: GO:2000902 +name: cellooligosaccharide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a cellooligosaccharide." [GOC:mengo_curators] +synonym: "cellooligosaccharide metabolism" EXACT [GOC:obol] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:2000903 +name: cellooligosaccharide catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a cellooligosaccharide." [GOC:mengo_curators] +synonym: "cellooligosaccharide catabolism" EXACT [GOC:obol] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:2000902 ! cellooligosaccharide metabolic process + +[Term] +id: GO:2000904 +name: regulation of starch metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of starch metabolic process." [GOC:obol] +synonym: "regulation of starch metabolism" EXACT [GOC:obol] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0005982 ! starch metabolic process + +[Term] +id: GO:2000905 +name: negative regulation of starch metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of starch metabolic process." [GOC:obol] +synonym: "negative regulation of starch metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000904 ! regulation of starch metabolic process +relationship: negatively_regulates GO:0005982 ! starch metabolic process + +[Term] +id: GO:2000906 +name: positive regulation of starch metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of starch metabolic process." [GOC:obol] +synonym: "positive regulation of starch metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000904 ! regulation of starch metabolic process +relationship: positively_regulates GO:0005982 ! starch metabolic process + +[Term] +id: GO:2000907 +name: negative regulation of glucomannan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of glucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000898 ! regulation of glucomannan catabolic process +relationship: negatively_regulates GO:2000884 ! glucomannan catabolic process + +[Term] +id: GO:2000908 +name: positive regulation of glucomannan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of glucomannan catabolism" EXACT [GOC:obol] +is_a: GO:2000898 ! regulation of glucomannan catabolic process +is_a: GO:2000996 ! positive regulation of mannan catabolic process +relationship: positively_regulates GO:2000884 ! glucomannan catabolic process + +[Term] +id: GO:2000909 +name: regulation of sterol import +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of sterol import." [GOC:obol] +synonym: "regulation of sterol influx" EXACT [GOC:obol] +synonym: "regulation of sterol uptake" EXACT [GOC:obol] +is_a: GO:0032371 ! regulation of sterol transport +relationship: regulates GO:0035376 ! sterol import + +[Term] +id: GO:2000910 +name: negative regulation of sterol import +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of sterol import." [GOC:obol] +synonym: "negative regulation of sterol influx" EXACT [GOC:obol] +synonym: "negative regulation of sterol uptake" EXACT [GOC:obol] +is_a: GO:0032372 ! negative regulation of sterol transport +is_a: GO:2000909 ! regulation of sterol import +relationship: negatively_regulates GO:0035376 ! sterol import + +[Term] +id: GO:2000911 +name: positive regulation of sterol import +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of sterol import." [GOC:obol] +synonym: "positive regulation of sterol influx" EXACT [GOC:obol] +synonym: "positive regulation of sterol uptake" EXACT [GOC:obol] +is_a: GO:0032373 ! positive regulation of sterol transport +is_a: GO:2000909 ! regulation of sterol import +relationship: positively_regulates GO:0035376 ! sterol import + +[Term] +id: GO:2000912 +name: regulation of galactoglucomannan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] +synonym: "regulation of galactoglucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +relationship: regulates GO:2000885 ! galactoglucomannan catabolic process + +[Term] +id: GO:2000913 +name: negative regulation of galactoglucomannan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of galactoglucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process +relationship: negatively_regulates GO:2000885 ! galactoglucomannan catabolic process + +[Term] +id: GO:2000914 +name: positive regulation of galactoglucomannan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of galactoglucomannan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of galactoglucomannan catabolism" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000912 ! regulation of galactoglucomannan catabolic process +relationship: positively_regulates GO:2000885 ! galactoglucomannan catabolic process + +[Term] +id: GO:2000915 +name: regulation of glucuronoxylan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] +synonym: "regulation of glucuronoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2001000 ! regulation of xylan catabolic process +relationship: regulates GO:2000886 ! glucuronoxylan catabolic process + +[Term] +id: GO:2000916 +name: negative regulation of glucuronoxylan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of glucuronoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process +is_a: GO:2001001 ! negative regulation of xylan catabolic process +relationship: negatively_regulates GO:2000886 ! glucuronoxylan catabolic process + +[Term] +id: GO:2000917 +name: positive regulation of glucuronoxylan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucuronoxylan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of glucuronoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process +is_a: GO:2001002 ! positive regulation of xylan catabolic process +relationship: positively_regulates GO:2000886 ! glucuronoxylan catabolic process + +[Term] +id: GO:2000918 +name: regulation of glucuronoarabinoxylan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] +synonym: "regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000915 ! regulation of glucuronoxylan catabolic process +is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process +relationship: regulates GO:2000887 ! glucuronoarabinoxylan catabolic process + +[Term] +id: GO:2000919 +name: negative regulation of glucuronoarabinoxylan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000916 ! negative regulation of glucuronoxylan catabolic process +is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process +is_a: GO:2000922 ! negative regulation of arabinoxylan-containing compound catabolic process +relationship: negatively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process + +[Term] +id: GO:2000920 +name: positive regulation of glucuronoarabinoxylan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucuronoarabinoxylan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of glucuronoarabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000917 ! positive regulation of glucuronoxylan catabolic process +is_a: GO:2000918 ! regulation of glucuronoarabinoxylan catabolic process +is_a: GO:2000923 ! positive regulation of arabinoxylan-containing compound catabolic process +relationship: positively_regulates GO:2000887 ! glucuronoarabinoxylan catabolic process + +[Term] +id: GO:2000921 +name: regulation of arabinoxylan-containing compound catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] +synonym: "regulation of arabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2001000 ! regulation of xylan catabolic process +relationship: regulates GO:2000888 ! arabinoxylan-containing compound catabolic process + +[Term] +id: GO:2000922 +name: negative regulation of arabinoxylan-containing compound catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of arabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process +is_a: GO:2001001 ! negative regulation of xylan catabolic process +relationship: negatively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process + +[Term] +id: GO:2000923 +name: positive regulation of arabinoxylan-containing compound catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of arabinoxylan catabolism" EXACT [GOC:obol] +is_a: GO:2000921 ! regulation of arabinoxylan-containing compound catabolic process +is_a: GO:2001002 ! positive regulation of xylan catabolic process +relationship: positively_regulates GO:2000888 ! arabinoxylan-containing compound catabolic process + +[Term] +id: GO:2000924 +name: regulation of cellodextrin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] +synonym: "regulation of cellodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:2000889 ! cellodextrin metabolic process + +[Term] +id: GO:2000925 +name: negative regulation of cellodextrin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000924 ! regulation of cellodextrin metabolic process +relationship: negatively_regulates GO:2000889 ! cellodextrin metabolic process + +[Term] +id: GO:2000926 +name: positive regulation of cellodextrin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000924 ! regulation of cellodextrin metabolic process +relationship: positively_regulates GO:2000889 ! cellodextrin metabolic process + +[Term] +id: GO:2000927 +name: regulation of cellodextrin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] +synonym: "regulation of cellodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:2000924 ! regulation of cellodextrin metabolic process +relationship: regulates GO:2000890 ! cellodextrin catabolic process + +[Term] +id: GO:2000928 +name: negative regulation of cellodextrin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process +is_a: GO:2000927 ! regulation of cellodextrin catabolic process +relationship: negatively_regulates GO:2000890 ! cellodextrin catabolic process + +[Term] +id: GO:2000929 +name: positive regulation of cellodextrin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellodextrin catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process +is_a: GO:2000927 ! regulation of cellodextrin catabolic process +relationship: positively_regulates GO:2000890 ! cellodextrin catabolic process + +[Term] +id: GO:2000930 +name: regulation of cellobiose metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] +synonym: "regulation of cellobiose metabolism" EXACT [GOC:obol] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +relationship: regulates GO:2000891 ! cellobiose metabolic process + +[Term] +id: GO:2000931 +name: negative regulation of cellobiose metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellobiose metabolism" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000930 ! regulation of cellobiose metabolic process +relationship: negatively_regulates GO:2000891 ! cellobiose metabolic process + +[Term] +id: GO:2000932 +name: positive regulation of cellobiose metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellobiose metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellobiose metabolism" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000930 ! regulation of cellobiose metabolic process +relationship: positively_regulates GO:2000891 ! cellobiose metabolic process + +[Term] +id: GO:2000933 +name: regulation of cellotriose metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] +synonym: "regulation of cellotriose metabolism" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:2000893 ! cellotriose metabolic process + +[Term] +id: GO:2000934 +name: negative regulation of cellotriose metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellotriose metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000933 ! regulation of cellotriose metabolic process +relationship: negatively_regulates GO:2000893 ! cellotriose metabolic process + +[Term] +id: GO:2000935 +name: positive regulation of cellotriose metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellotriose metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000933 ! regulation of cellotriose metabolic process +relationship: positively_regulates GO:2000893 ! cellotriose metabolic process + +[Term] +id: GO:2000936 +name: regulation of cellotriose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] +synonym: "regulation of cellotriose catabolism" EXACT [GOC:obol] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:2000933 ! regulation of cellotriose metabolic process +relationship: regulates GO:2000894 ! cellotriose catabolic process + +[Term] +id: GO:2000937 +name: negative regulation of cellotriose catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellotriose catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:2000934 ! negative regulation of cellotriose metabolic process +is_a: GO:2000936 ! regulation of cellotriose catabolic process +relationship: negatively_regulates GO:2000894 ! cellotriose catabolic process + +[Term] +id: GO:2000938 +name: positive regulation of cellotriose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellotriose catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellotriose catabolism" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:2000935 ! positive regulation of cellotriose metabolic process +is_a: GO:2000936 ! regulation of cellotriose catabolic process +relationship: positively_regulates GO:2000894 ! cellotriose catabolic process + +[Term] +id: GO:2000939 +name: regulation of plant-type cell wall cellulose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] +synonym: "regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: regulates GO:0044348 ! plant-type cell wall cellulose catabolic process + +[Term] +id: GO:2000940 +name: negative regulation of plant-type cell wall cellulose catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process +is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process +relationship: negatively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process + +[Term] +id: GO:2000941 +name: positive regulation of plant-type cell wall cellulose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of plant-type cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000939 ! regulation of plant-type cell wall cellulose catabolic process +is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process +relationship: positively_regulates GO:0044348 ! plant-type cell wall cellulose catabolic process + +[Term] +id: GO:2000942 +name: regulation of amylopectin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] +synonym: "regulation of Amylopectin metabolism" EXACT [GOC:obol] +is_a: GO:0031323 ! regulation of cellular metabolic process +is_a: GO:0060255 ! regulation of macromolecule metabolic process +relationship: regulates GO:2000896 ! amylopectin metabolic process + +[Term] +id: GO:2000943 +name: negative regulation of amylopectin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of Amylopectin metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031324 ! negative regulation of cellular metabolic process +is_a: GO:2000942 ! regulation of amylopectin metabolic process +relationship: negatively_regulates GO:2000896 ! amylopectin metabolic process + +[Term] +id: GO:2000944 +name: positive regulation of amylopectin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of Amylopectin metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:2000942 ! regulation of amylopectin metabolic process +relationship: positively_regulates GO:2000896 ! amylopectin metabolic process + +[Term] +id: GO:2000945 +name: regulation of amylopectin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] +synonym: "regulation of Amylopectin catabolism" EXACT [GOC:obol] +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:2000942 ! regulation of amylopectin metabolic process +relationship: regulates GO:2000897 ! amylopectin catabolic process + +[Term] +id: GO:2000946 +name: negative regulation of amylopectin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of Amylopectin catabolism" EXACT [GOC:obol] +is_a: GO:2000882 ! negative regulation of starch catabolic process +is_a: GO:2000943 ! negative regulation of amylopectin metabolic process +is_a: GO:2000945 ! regulation of amylopectin catabolic process +relationship: negatively_regulates GO:2000897 ! amylopectin catabolic process + +[Term] +id: GO:2000947 +name: positive regulation of amylopectin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of Amylopectin catabolism" EXACT [GOC:obol] +is_a: GO:2000883 ! positive regulation of starch catabolic process +is_a: GO:2000944 ! positive regulation of amylopectin metabolic process +is_a: GO:2000945 ! regulation of amylopectin catabolic process +relationship: positively_regulates GO:2000897 ! amylopectin catabolic process + +[Term] +id: GO:2000948 +name: regulation of xyloglucan metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] +synonym: "regulation of xyloglucan metabolism" EXACT [GOC:obol] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:0010411 ! xyloglucan metabolic process + +[Term] +id: GO:2000949 +name: negative regulation of xyloglucan metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of xyloglucan metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000948 ! regulation of xyloglucan metabolic process +relationship: negatively_regulates GO:0010411 ! xyloglucan metabolic process + +[Term] +id: GO:2000950 +name: positive regulation of xyloglucan metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xyloglucan metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of xyloglucan metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000948 ! regulation of xyloglucan metabolic process +relationship: positively_regulates GO:0010411 ! xyloglucan metabolic process + +[Term] +id: GO:2000951 +name: regulation of xyloglucan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] +synonym: "regulation of xyloglucan catabolism" EXACT [GOC:obol] +is_a: GO:2000948 ! regulation of xyloglucan metabolic process +is_a: GO:2000988 ! regulation of hemicellulose catabolic process +relationship: regulates GO:2000899 ! xyloglucan catabolic process + +[Term] +id: GO:2000952 +name: negative regulation of xyloglucan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of xyloglucan catabolism" EXACT [GOC:obol] +is_a: GO:2000949 ! negative regulation of xyloglucan metabolic process +is_a: GO:2000951 ! regulation of xyloglucan catabolic process +is_a: GO:2000989 ! negative regulation of hemicellulose catabolic process +relationship: negatively_regulates GO:2000899 ! xyloglucan catabolic process + +[Term] +id: GO:2000953 +name: positive regulation of xyloglucan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xyloglucan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of xyloglucan catabolism" EXACT [GOC:obol] +is_a: GO:2000950 ! positive regulation of xyloglucan metabolic process +is_a: GO:2000951 ! regulation of xyloglucan catabolic process +is_a: GO:2000990 ! positive regulation of hemicellulose catabolic process +relationship: positively_regulates GO:2000899 ! xyloglucan catabolic process + +[Term] +id: GO:2000954 +name: regulation of cyclodextrin metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] +synonym: "regulation of cyclodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +relationship: regulates GO:2000900 ! cyclodextrin metabolic process + +[Term] +id: GO:2000955 +name: negative regulation of cyclodextrin metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cyclodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000954 ! regulation of cyclodextrin metabolic process +relationship: negatively_regulates GO:2000900 ! cyclodextrin metabolic process + +[Term] +id: GO:2000956 +name: positive regulation of cyclodextrin metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cyclodextrin metabolism" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000954 ! regulation of cyclodextrin metabolic process +relationship: positively_regulates GO:2000900 ! cyclodextrin metabolic process + +[Term] +id: GO:2000957 +name: regulation of cyclodextrin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] +synonym: "regulation of cyclodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:2000954 ! regulation of cyclodextrin metabolic process +relationship: regulates GO:2000901 ! cyclodextrin catabolic process + +[Term] +id: GO:2000958 +name: negative regulation of cyclodextrin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cyclodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:2000955 ! negative regulation of cyclodextrin metabolic process +is_a: GO:2000957 ! regulation of cyclodextrin catabolic process +relationship: negatively_regulates GO:2000901 ! cyclodextrin catabolic process + +[Term] +id: GO:2000959 +name: positive regulation of cyclodextrin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cyclodextrin catabolism" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:2000956 ! positive regulation of cyclodextrin metabolic process +is_a: GO:2000957 ! regulation of cyclodextrin catabolic process +relationship: positively_regulates GO:2000901 ! cyclodextrin catabolic process + +[Term] +id: GO:2000960 +name: regulation of cellooligosaccharide metabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] +synonym: "regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] +is_a: GO:0006109 ! regulation of carbohydrate metabolic process +relationship: regulates GO:2000902 ! cellooligosaccharide metabolic process + +[Term] +id: GO:2000961 +name: negative regulation of cellooligosaccharide metabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process +relationship: negatively_regulates GO:2000902 ! cellooligosaccharide metabolic process + +[Term] +id: GO:2000962 +name: positive regulation of cellooligosaccharide metabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellooligosaccharide metabolism" EXACT [GOC:obol] +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process +relationship: positively_regulates GO:2000902 ! cellooligosaccharide metabolic process + +[Term] +id: GO:2000963 +name: regulation of cellooligosaccharide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] +synonym: "regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +is_a: GO:2000960 ! regulation of cellooligosaccharide metabolic process +relationship: regulates GO:2000903 ! cellooligosaccharide catabolic process + +[Term] +id: GO:2000964 +name: negative regulation of cellooligosaccharide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:2000961 ! negative regulation of cellooligosaccharide metabolic process +is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process +relationship: negatively_regulates GO:2000903 ! cellooligosaccharide catabolic process + +[Term] +id: GO:2000965 +name: positive regulation of cellooligosaccharide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellooligosaccharide catabolism" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:2000962 ! positive regulation of cellooligosaccharide metabolic process +is_a: GO:2000963 ! regulation of cellooligosaccharide catabolic process +relationship: positively_regulates GO:2000903 ! cellooligosaccharide catabolic process + +[Term] +id: GO:2000966 +name: regulation of cell wall polysaccharide catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] +synonym: "regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:0031329 ! regulation of cellular catabolic process +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +relationship: regulates GO:0044347 ! cell wall polysaccharide catabolic process + +[Term] +id: GO:2000967 +name: negative regulation of cell wall polysaccharide catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: negatively_regulates GO:0044347 ! cell wall polysaccharide catabolic process + +[Term] +id: GO:2000968 +name: positive regulation of cell wall polysaccharide catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cell wall polysaccharide breakdown" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: positively_regulates GO:0044347 ! cell wall polysaccharide catabolic process + +[Term] +id: GO:2000969 +name: positive regulation of AMPA receptor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of AMPA selective glutamate receptor activity." [PMID:21423165] +synonym: "positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" BROAD [] +is_a: GO:2000273 ! positive regulation of signaling receptor activity +is_a: GO:2000311 ! regulation of AMPA receptor activity +is_a: GO:2001259 ! positive regulation of cation channel activity + +[Term] +id: GO:2000970 +name: regulation of detection of glucose +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of detection of glucose." [GOC:BHF] +synonym: "regulation of glucose detection" EXACT [GOC:obol] +synonym: "regulation of glucose perception" RELATED [GOC:obol] +synonym: "regulation of glucose sensing" RELATED [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0051594 ! detection of glucose + +[Term] +id: GO:2000971 +name: negative regulation of detection of glucose +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose." [GOC:BHF] +synonym: "negative regulation of glucose detection" EXACT [GOC:obol] +synonym: "negative regulation of glucose perception" RELATED [GOC:obol] +synonym: "negative regulation of glucose sensing" RELATED [GOC:obol] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2000970 ! regulation of detection of glucose +relationship: negatively_regulates GO:0051594 ! detection of glucose + +[Term] +id: GO:2000972 +name: positive regulation of detection of glucose +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of detection of glucose." [GOC:BHF] +synonym: "positive regulation of glucose detection" EXACT [GOC:obol] +synonym: "positive regulation of glucose perception" RELATED [GOC:obol] +synonym: "positive regulation of glucose sensing" RELATED [GOC:obol] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2000970 ! regulation of detection of glucose +relationship: positively_regulates GO:0051594 ! detection of glucose + +[Term] +id: GO:2000973 +name: regulation of pro-B cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] +synonym: "regulation of pro-B cell development" RELATED [GOC:obol] +synonym: "regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:1905456 ! regulation of lymphoid progenitor cell differentiation +relationship: regulates GO:0002328 ! pro-B cell differentiation + +[Term] +id: GO:2000974 +name: negative regulation of pro-B cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] +synonym: "negative regulation of pro-B cell development" RELATED [GOC:obol] +synonym: "negative regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:1905457 ! negative regulation of lymphoid progenitor cell differentiation +is_a: GO:2000973 ! regulation of pro-B cell differentiation +relationship: negatively_regulates GO:0002328 ! pro-B cell differentiation + +[Term] +id: GO:2000975 +name: positive regulation of pro-B cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation." [GOC:obol] +synonym: "positive regulation of pro-B cell development" RELATED [GOC:obol] +synonym: "positive regulation of pro-B lymphocyte differentiation" EXACT [GOC:obol] +is_a: GO:1905458 ! positive regulation of lymphoid progenitor cell differentiation +is_a: GO:2000973 ! regulation of pro-B cell differentiation +relationship: positively_regulates GO:0002328 ! pro-B cell differentiation + +[Term] +id: GO:2000976 +name: obsolete regulation of transcription from RNA polymerase II promoter involved in detection of glucose +namespace: biological_process +def: "OBSOLETE. Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose." [GOC:BHF] +comment: This term was made obsolete is that in these terms the 'involved in' process is not truly involved_in (i.e. part_of) the process but instead is causally upstream of it. We advise replacing annotations to these terms with annotations + extensions using the causally_upstream_of relation e.g. P1234 regulation of gene expression [causally_upstream_of] extracellular matrix organization. +synonym: "global transcription regulation from Pol II promoter involved in detection of glucose" RELATED [GOC:obol] +synonym: "global transcription regulation from Pol II promoter involved in glucose detection" RELATED [GOC:obol] +synonym: "global transcription regulation from Pol II promoter involved in glucose perception" RELATED [GOC:obol] +synonym: "global transcription regulation from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in detection of glucose" RELATED [GOC:obol] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose detection" RELATED [GOC:obol] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol] +synonym: "regulation of gene-specific transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol] +synonym: "regulation of global transcription from Pol II promoter involved in detection of glucose" RELATED [GOC:obol] +synonym: "regulation of global transcription from Pol II promoter involved in glucose detection" RELATED [GOC:obol] +synonym: "regulation of global transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol] +synonym: "regulation of global transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] +synonym: "regulation of transcription from Pol II promoter involved in detection of glucose" EXACT [GOC:obol] +synonym: "regulation of transcription from Pol II promoter involved in glucose detection" EXACT [GOC:obol] +synonym: "regulation of transcription from Pol II promoter involved in glucose perception" RELATED [GOC:obol] +synonym: "regulation of transcription from Pol II promoter involved in glucose sensing" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose detection" EXACT [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose perception" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter involved in glucose sensing" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in detection of glucose" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose detection" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose perception" RELATED [GOC:obol] +synonym: "regulation of transcription from RNA polymerase II promoter, global involved in glucose sensing" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0006357 +consider: GO:0051594 + +[Term] +id: GO:2000977 +name: regulation of forebrain neuron differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] +is_a: GO:0045664 ! regulation of neuron differentiation +relationship: regulates GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:2000978 +name: negative regulation of forebrain neuron differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] +is_a: GO:0045665 ! negative regulation of neuron differentiation +is_a: GO:2000977 ! regulation of forebrain neuron differentiation +relationship: negatively_regulates GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:2000979 +name: positive regulation of forebrain neuron differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation." [GOC:obol] +is_a: GO:0045666 ! positive regulation of neuron differentiation +is_a: GO:2000977 ! regulation of forebrain neuron differentiation +relationship: positively_regulates GO:0021879 ! forebrain neuron differentiation + +[Term] +id: GO:2000980 +name: regulation of inner ear receptor cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] +synonym: "regulation of inner ear hair cell differentiation" EXACT [GOC:obol] +is_a: GO:0045631 ! regulation of mechanoreceptor differentiation +relationship: regulates GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:2000981 +name: negative regulation of inner ear receptor cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] +synonym: "negative regulation of inner ear hair cell differentiation" EXACT [GOC:obol] +is_a: GO:0045632 ! negative regulation of mechanoreceptor differentiation +is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation +relationship: negatively_regulates GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:2000982 +name: positive regulation of inner ear receptor cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." [GOC:obol] +synonym: "positive regulation of inner ear hair cell differentiation" EXACT [GOC:obol] +is_a: GO:0045633 ! positive regulation of mechanoreceptor differentiation +is_a: GO:2000980 ! regulation of inner ear receptor cell differentiation +relationship: positively_regulates GO:0060113 ! inner ear receptor cell differentiation + +[Term] +id: GO:2000983 +name: regulation of ATP citrate synthase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] +synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] +synonym: "regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] +synonym: "regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] +synonym: "regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] +synonym: "regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] +synonym: "regulation of ATP-citric lyase activity" EXACT [GOC:obol] +synonym: "regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] +synonym: "regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] +synonym: "regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] +synonym: "regulation of citrate-ATP lyase activity" EXACT [GOC:obol] +synonym: "regulation of citric cleavage enzyme activity" RELATED [GOC:obol] +is_a: GO:0051338 ! regulation of transferase activity + +[Term] +id: GO:2000984 +name: negative regulation of ATP citrate synthase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] +synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] +synonym: "negative regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] +synonym: "negative regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] +synonym: "negative regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP-citric lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] +synonym: "negative regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] +synonym: "negative regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] +synonym: "negative regulation of citrate-ATP lyase activity" EXACT [GOC:obol] +synonym: "negative regulation of citric cleavage enzyme activity" RELATED [GOC:obol] +is_a: GO:0051348 ! negative regulation of transferase activity +is_a: GO:2000983 ! regulation of ATP citrate synthase activity + +[Term] +id: GO:2000985 +name: positive regulation of ATP citrate synthase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity." [GOC:BHF] +synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [GOC:obol] +synonym: "positive regulation of acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [GOC:obol] +synonym: "positive regulation of acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [GOC:obol] +synonym: "positive regulation of adenosine triphosphate citrate lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP-citrate (pro-S)-lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP-citrate (pro-S-)-lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP-citric lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [GOC:obol] +synonym: "positive regulation of ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [GOC:obol] +synonym: "positive regulation of citrate cleavage enzyme activity" RELATED [GOC:obol] +synonym: "positive regulation of citrate-ATP lyase activity" EXACT [GOC:obol] +synonym: "positive regulation of citric cleavage enzyme activity" RELATED [GOC:obol] +is_a: GO:0051347 ! positive regulation of transferase activity +is_a: GO:2000983 ! regulation of ATP citrate synthase activity + +[Term] +id: GO:2000986 +name: negative regulation of behavioral fear response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response." [GOC:obol] +synonym: "negative regulation of behavioural fear response" EXACT [GOC:obol] +is_a: GO:0031348 ! negative regulation of defense response +is_a: GO:0048521 ! negative regulation of behavior +is_a: GO:1903366 ! negative regulation of fear response +is_a: GO:2000822 ! regulation of behavioral fear response +relationship: negatively_regulates GO:0001662 ! behavioral fear response + +[Term] +id: GO:2000987 +name: positive regulation of behavioral fear response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of behavioral fear response." [GOC:obol] +synonym: "positive regulation of behavioural fear response" EXACT [GOC:obol] +is_a: GO:0031349 ! positive regulation of defense response +is_a: GO:0048520 ! positive regulation of behavior +is_a: GO:1903367 ! positive regulation of fear response +is_a: GO:2000822 ! regulation of behavioral fear response +relationship: positively_regulates GO:0001662 ! behavioral fear response + +[Term] +id: GO:2000988 +name: regulation of hemicellulose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] +synonym: "regulation of hemicellulose catabolism" EXACT [GOC:obol] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: regulates GO:2000895 ! hemicellulose catabolic process + +[Term] +id: GO:2000989 +name: negative regulation of hemicellulose catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of hemicellulose catabolism" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process +is_a: GO:2000988 ! regulation of hemicellulose catabolic process +relationship: negatively_regulates GO:2000895 ! hemicellulose catabolic process + +[Term] +id: GO:2000990 +name: positive regulation of hemicellulose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of hemicellulose catabolism" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process +is_a: GO:2000988 ! regulation of hemicellulose catabolic process +relationship: positively_regulates GO:2000895 ! hemicellulose catabolic process + +[Term] +id: GO:2000991 +name: regulation of galactomannan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043470 ! regulation of carbohydrate catabolic process +relationship: regulates GO:0051682 ! galactomannan catabolic process + +[Term] +id: GO:2000992 +name: negative regulation of galactomannan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process +is_a: GO:2000991 ! regulation of galactomannan catabolic process +relationship: negatively_regulates GO:0051682 ! galactomannan catabolic process + +[Term] +id: GO:2000993 +name: positive regulation of galactomannan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process." [GOC:mengo_curators] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process +is_a: GO:2000991 ! regulation of galactomannan catabolic process +relationship: positively_regulates GO:0051682 ! galactomannan catabolic process + +[Term] +id: GO:2000994 +name: regulation of mannan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] +synonym: "regulation of mannan breakdown" EXACT [GOC:obol] +synonym: "regulation of mannan catabolism" EXACT [GOC:obol] +synonym: "regulation of mannan degradation" EXACT [GOC:obol] +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:2000924 ! regulation of cellodextrin metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: regulates GO:0046355 ! mannan catabolic process + +[Term] +id: GO:2000995 +name: negative regulation of mannan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of mannan breakdown" EXACT [GOC:obol] +synonym: "negative regulation of mannan catabolism" EXACT [GOC:obol] +synonym: "negative regulation of mannan degradation" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process +is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process +is_a: GO:2000994 ! regulation of mannan catabolic process +relationship: negatively_regulates GO:0046355 ! mannan catabolic process + +[Term] +id: GO:2000996 +name: positive regulation of mannan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mannan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of mannan breakdown" EXACT [GOC:obol] +synonym: "positive regulation of mannan catabolism" EXACT [GOC:obol] +synonym: "positive regulation of mannan degradation" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process +is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process +is_a: GO:2000994 ! regulation of mannan catabolic process +relationship: positively_regulates GO:0046355 ! mannan catabolic process + +[Term] +id: GO:2000997 +name: regulation of cellulose catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] +synonym: "regulation of cellulose breakdown" EXACT [GOC:obol] +synonym: "regulation of cellulose catabolism" EXACT [GOC:obol] +synonym: "regulation of cellulose degradation" EXACT [GOC:obol] +is_a: GO:0032950 ! regulation of beta-glucan metabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0030245 ! cellulose catabolic process + +[Term] +id: GO:2000998 +name: negative regulation of cellulose catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of cellulose breakdown" EXACT [GOC:obol] +synonym: "negative regulation of cellulose catabolism" EXACT [GOC:obol] +synonym: "negative regulation of cellulose degradation" EXACT [GOC:obol] +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0031330 ! negative regulation of cellular catabolic process +is_a: GO:2000997 ! regulation of cellulose catabolic process +relationship: negatively_regulates GO:0030245 ! cellulose catabolic process + +[Term] +id: GO:2000999 +name: positive regulation of cellulose catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellulose catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of cellulose breakdown" EXACT [GOC:obol] +synonym: "positive regulation of cellulose catabolism" EXACT [GOC:obol] +synonym: "positive regulation of cellulose degradation" EXACT [GOC:obol] +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031331 ! positive regulation of cellular catabolic process +is_a: GO:2000997 ! regulation of cellulose catabolic process +relationship: positively_regulates GO:0030245 ! cellulose catabolic process + +[Term] +id: GO:2001000 +name: regulation of xylan catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] +synonym: "regulation of xylan breakdown" EXACT [GOC:obol] +synonym: "regulation of xylan catabolism" EXACT [GOC:obol] +synonym: "regulation of xylan degradation" EXACT [GOC:obol] +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +is_a: GO:2000924 ! regulation of cellodextrin metabolic process +is_a: GO:2000966 ! regulation of cell wall polysaccharide catabolic process +relationship: regulates GO:0045493 ! xylan catabolic process + +[Term] +id: GO:2001001 +name: negative regulation of xylan catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of xylan breakdown" EXACT [GOC:obol] +synonym: "negative regulation of xylan catabolism" EXACT [GOC:obol] +synonym: "negative regulation of xylan degradation" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000925 ! negative regulation of cellodextrin metabolic process +is_a: GO:2000967 ! negative regulation of cell wall polysaccharide catabolic process +is_a: GO:2001000 ! regulation of xylan catabolic process +relationship: negatively_regulates GO:0045493 ! xylan catabolic process + +[Term] +id: GO:2001002 +name: positive regulation of xylan catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of xylan catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of xylan breakdown" EXACT [GOC:obol] +synonym: "positive regulation of xylan catabolism" EXACT [GOC:obol] +synonym: "positive regulation of xylan degradation" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2000926 ! positive regulation of cellodextrin metabolic process +is_a: GO:2000968 ! positive regulation of cell wall polysaccharide catabolic process +is_a: GO:2001000 ! regulation of xylan catabolic process +relationship: positively_regulates GO:0045493 ! xylan catabolic process + +[Term] +id: GO:2001003 +name: regulation of pectin catabolic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] +synonym: "regulation of pectin breakdown" EXACT [GOC:obol] +synonym: "regulation of pectin catabolism" EXACT [GOC:obol] +synonym: "regulation of pectin degradation" EXACT [GOC:obol] +is_a: GO:0032881 ! regulation of polysaccharide metabolic process +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +relationship: regulates GO:0045490 ! pectin catabolic process + +[Term] +id: GO:2001004 +name: negative regulation of pectin catabolic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] +synonym: "negative regulation of pectin breakdown" EXACT [GOC:obol] +synonym: "negative regulation of pectin catabolism" EXACT [GOC:obol] +synonym: "negative regulation of pectin degradation" EXACT [GOC:obol] +is_a: GO:0009895 ! negative regulation of catabolic process +is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2001003 ! regulation of pectin catabolic process +relationship: negatively_regulates GO:0045490 ! pectin catabolic process + +[Term] +id: GO:2001005 +name: positive regulation of pectin catabolic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of pectin catabolic process." [GOC:mengo_curators] +synonym: "positive regulation of pectin breakdown" EXACT [GOC:obol] +synonym: "positive regulation of pectin catabolism" EXACT [GOC:obol] +synonym: "positive regulation of pectin degradation" EXACT [GOC:obol] +is_a: GO:0009896 ! positive regulation of catabolic process +is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:2001003 ! regulation of pectin catabolic process +relationship: positively_regulates GO:0045490 ! pectin catabolic process + +[Term] +id: GO:2001006 +name: regulation of cellulose biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "regulation of cellulose anabolism" EXACT [GOC:obol] +synonym: "regulation of cellulose biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellulose formation" EXACT [GOC:obol] +synonym: "regulation of cellulose synthesis" EXACT [GOC:obol] +is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process +relationship: regulates GO:0030244 ! cellulose biosynthetic process + +[Term] +id: GO:2001007 +name: negative regulation of cellulose biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "negative regulation of cellulose anabolism" EXACT [GOC:obol] +synonym: "negative regulation of cellulose biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellulose formation" EXACT [GOC:obol] +synonym: "negative regulation of cellulose synthesis" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process +is_a: GO:2001006 ! regulation of cellulose biosynthetic process +relationship: negatively_regulates GO:0030244 ! cellulose biosynthetic process + +[Term] +id: GO:2001008 +name: positive regulation of cellulose biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "positive regulation of cellulose anabolism" EXACT [GOC:obol] +synonym: "positive regulation of cellulose biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cellulose formation" EXACT [GOC:obol] +synonym: "positive regulation of cellulose synthesis" EXACT [GOC:obol] +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process +is_a: GO:2001006 ! regulation of cellulose biosynthetic process +relationship: positively_regulates GO:0030244 ! cellulose biosynthetic process + +[Term] +id: GO:2001009 +name: regulation of plant-type cell wall cellulose biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] +is_a: GO:0010981 ! regulation of cell wall macromolecule metabolic process +is_a: GO:2001006 ! regulation of cellulose biosynthetic process +relationship: regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process + +[Term] +id: GO:2001010 +name: negative regulation of plant-type cell wall cellulose biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "negative regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] +is_a: GO:2001007 ! negative regulation of cellulose biosynthetic process +is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process +relationship: negatively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process + +[Term] +id: GO:2001011 +name: positive regulation of plant-type cell wall cellulose biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process." [GOC:mengo_curators] +synonym: "positive regulation of cell wall cellulose biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cellulose biosynthesis during cell wall biosynthesis" RELATED [GOC:obol] +is_a: GO:0044089 ! positive regulation of cellular component biogenesis +is_a: GO:2001008 ! positive regulation of cellulose biosynthetic process +is_a: GO:2001009 ! regulation of plant-type cell wall cellulose biosynthetic process +relationship: positively_regulates GO:0052324 ! plant-type cell wall cellulose biosynthetic process + +[Term] +id: GO:2001012 +name: mesenchymal cell differentiation involved in renal system development +namespace: biological_process +def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf] +synonym: "mesenchymal cell differentiation involved in urinary system development" RELATED [GOC:obol] +synonym: "mesenchymal cell differentiation involved in urinary tract development" RELATED [GOC:obol] +is_a: GO:0048762 ! mesenchymal cell differentiation +relationship: part_of GO:0072001 ! renal system development + +[Term] +id: GO:2001013 +name: epithelial cell proliferation involved in renal tubule morphogenesis +namespace: biological_process +def: "Any epithelial cell proliferation that is involved in renal tubule morphogenesis." [GOC:obol] +is_a: GO:0050673 ! epithelial cell proliferation +relationship: part_of GO:0061333 ! renal tubule morphogenesis + +[Term] +id: GO:2001014 +name: regulation of skeletal muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0035914 ! skeletal muscle cell differentiation + +[Term] +id: GO:2001015 +name: negative regulation of skeletal muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation +relationship: negatively_regulates GO:0035914 ! skeletal muscle cell differentiation + +[Term] +id: GO:2001016 +name: positive regulation of skeletal muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation." [GOC:obol] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:2001014 ! regulation of skeletal muscle cell differentiation +relationship: positively_regulates GO:0035914 ! skeletal muscle cell differentiation + +[Term] +id: GO:2001017 +name: regulation of retrograde axon cargo transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] +synonym: "regulation of retrograde axonal transport" EXACT [GOC:obol] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060632 ! regulation of microtubule-based movement +relationship: regulates GO:0008090 ! retrograde axonal transport + +[Term] +id: GO:2001018 +name: negative regulation of retrograde axon cargo transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] +synonym: "negative regulation of retrograde axonal transport" EXACT [GOC:obol] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0051271 ! negative regulation of cellular component movement +is_a: GO:2001017 ! regulation of retrograde axon cargo transport +relationship: negatively_regulates GO:0008090 ! retrograde axonal transport + +[Term] +id: GO:2001019 +name: positive regulation of retrograde axon cargo transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport." [GOC:obol] +synonym: "positive regulation of retrograde axonal transport" EXACT [GOC:obol] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0051272 ! positive regulation of cellular component movement +is_a: GO:2001017 ! regulation of retrograde axon cargo transport +relationship: positively_regulates GO:0008090 ! retrograde axonal transport + +[Term] +id: GO:2001020 +name: regulation of response to DNA damage stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] +synonym: "regulation of cellular DNA damage response" EXACT [GOC:obol] +synonym: "regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "regulation of DNA damage response" EXACT [GOC:obol] +synonym: "regulation of response to genotoxic stress" EXACT [GOC:obol] +is_a: GO:0080135 ! regulation of cellular response to stress +relationship: regulates GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:2001021 +name: negative regulation of response to DNA damage stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] +synonym: "negative regulation of cellular DNA damage response" EXACT [GOC:obol] +synonym: "negative regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "negative regulation of DNA damage response" EXACT [GOC:obol] +synonym: "negative regulation of response to genotoxic stress" EXACT [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: negatively_regulates GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:2001022 +name: positive regulation of response to DNA damage stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus." [GOC:obol] +synonym: "positive regulation of cellular DNA damage response" EXACT [GOC:obol] +synonym: "positive regulation of cellular response to DNA damage stimulus" EXACT [GOC:obol] +synonym: "positive regulation of DNA damage response" EXACT [GOC:obol] +synonym: "positive regulation of response to genotoxic stress" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2001020 ! regulation of response to DNA damage stimulus +relationship: positively_regulates GO:0006974 ! cellular response to DNA damage stimulus + +[Term] +id: GO:2001023 +name: regulation of response to drug +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to drug." [GOC:obol] +synonym: "regulation of drug resistance" RELATED [GOC:obol] +synonym: "regulation of drug susceptibility/resistance" RELATED [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0009410 ! response to xenobiotic stimulus + +[Term] +id: GO:2001024 +name: negative regulation of response to drug +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to drug." [GOC:obol] +synonym: "negative regulation of drug resistance" RELATED [GOC:obol] +synonym: "negative regulation of drug susceptibility/resistance" RELATED [GOC:obol] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2001023 ! regulation of response to drug +relationship: negatively_regulates GO:0009410 ! response to xenobiotic stimulus + +[Term] +id: GO:2001025 +name: positive regulation of response to drug +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to drug." [GOC:obol] +synonym: "positive regulation of drug resistance" RELATED [GOC:obol] +synonym: "positive regulation of drug susceptibility/resistance" RELATED [GOC:obol] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2001023 ! regulation of response to drug +relationship: positively_regulates GO:0009410 ! response to xenobiotic stimulus + +[Term] +id: GO:2001026 +name: regulation of endothelial cell chemotaxis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] +is_a: GO:0010594 ! regulation of endothelial cell migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0035767 ! endothelial cell chemotaxis + +[Term] +id: GO:2001027 +name: negative regulation of endothelial cell chemotaxis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] +is_a: GO:0010596 ! negative regulation of endothelial cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:2001026 ! regulation of endothelial cell chemotaxis +relationship: negatively_regulates GO:0035767 ! endothelial cell chemotaxis + +[Term] +id: GO:2001028 +name: positive regulation of endothelial cell chemotaxis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:BHF] +is_a: GO:0010595 ! positive regulation of endothelial cell migration +is_a: GO:0050921 ! positive regulation of chemotaxis +is_a: GO:2001026 ! regulation of endothelial cell chemotaxis +relationship: positively_regulates GO:0035767 ! endothelial cell chemotaxis + +[Term] +id: GO:2001029 +name: regulation of cellular glucuronidation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] +synonym: "regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] +synonym: "regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] +synonym: "regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] +is_a: GO:0010565 ! regulation of cellular ketone metabolic process +is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process +relationship: regulates GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:2001030 +name: negative regulation of cellular glucuronidation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] +synonym: "negative regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] +synonym: "negative regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:0062014 ! negative regulation of small molecule metabolic process +is_a: GO:2001029 ! regulation of cellular glucuronidation +relationship: negatively_regulates GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:2001031 +name: positive regulation of cellular glucuronidation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular glucuronidation." [GOC:BHF] +synonym: "positive regulation of cellular glucuronide biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cellular glucuronide biosynthetic process" EXACT [GOC:obol] +synonym: "positive regulation of cellular glucuronoside biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of cellular glucuronoside biosynthetic process" EXACT [GOC:obol] +is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process +is_a: GO:0062013 ! positive regulation of small molecule metabolic process +is_a: GO:2001029 ! regulation of cellular glucuronidation +relationship: positively_regulates GO:0052695 ! cellular glucuronidation + +[Term] +id: GO:2001032 +name: regulation of double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] +synonym: "regulation of NHEJ" EXACT [GOC:obol] +is_a: GO:2000779 ! regulation of double-strand break repair +relationship: regulates GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:2001033 +name: negative regulation of double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] +synonym: "negative regulation of NHEJ" EXACT [GOC:obol] +is_a: GO:2000780 ! negative regulation of double-strand break repair +is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining +relationship: negatively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:2001034 +name: positive regulation of double-strand break repair via nonhomologous end joining +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining." [GOC:obol] +synonym: "positive regulation of NHEJ" EXACT [GOC:obol] +is_a: GO:2000781 ! positive regulation of double-strand break repair +is_a: GO:2001032 ! regulation of double-strand break repair via nonhomologous end joining +relationship: positively_regulates GO:0006303 ! double-strand break repair via nonhomologous end joining + +[Term] +id: GO:2001035 +name: regulation of tongue muscle cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] +is_a: GO:1902809 ! regulation of skeletal muscle fiber differentiation +relationship: regulates GO:0035981 ! tongue muscle cell differentiation + +[Term] +id: GO:2001036 +name: negative regulation of tongue muscle cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] +is_a: GO:1902810 ! negative regulation of skeletal muscle fiber differentiation +is_a: GO:2001035 ! regulation of tongue muscle cell differentiation +relationship: negatively_regulates GO:0035981 ! tongue muscle cell differentiation + +[Term] +id: GO:2001037 +name: positive regulation of tongue muscle cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation." [GOC:obol] +is_a: GO:1902811 ! positive regulation of skeletal muscle fiber differentiation +is_a: GO:2001035 ! regulation of tongue muscle cell differentiation +relationship: positively_regulates GO:0035981 ! tongue muscle cell differentiation + +[Term] +id: GO:2001038 +name: regulation of cellular response to drug +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to drug." [GOC:obol] +is_a: GO:0050794 ! regulation of cellular process +is_a: GO:2001023 ! regulation of response to drug +relationship: regulates GO:0071466 ! cellular response to xenobiotic stimulus + +[Term] +id: GO:2001039 +name: negative regulation of cellular response to drug +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to drug." [GOC:obol] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:2001024 ! negative regulation of response to drug +is_a: GO:2001038 ! regulation of cellular response to drug +relationship: negatively_regulates GO:0071466 ! cellular response to xenobiotic stimulus + +[Term] +id: GO:2001040 +name: positive regulation of cellular response to drug +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to drug." [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:2001025 ! positive regulation of response to drug +is_a: GO:2001038 ! regulation of cellular response to drug +relationship: positively_regulates GO:0071466 ! cellular response to xenobiotic stimulus + +[Term] +id: GO:2001042 +name: negative regulation of septum digestion after cytokinesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] +synonym: "negative regulation of cytokinetic cell separation" EXACT [] +is_a: GO:0010590 ! regulation of septum digestion after cytokinesis +is_a: GO:0048523 ! negative regulation of cellular process +relationship: negatively_regulates GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:2001043 +name: positive regulation of septum digestion after cytokinesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:obol] +synonym: "positive regulation of cell separation after cytokinesis" RELATED [] +synonym: "positive regulation of cytokinetic cell separation" RELATED [] +is_a: GO:0010590 ! regulation of septum digestion after cytokinesis +is_a: GO:0048522 ! positive regulation of cellular process +relationship: positively_regulates GO:0000920 ! septum digestion after cytokinesis + +[Term] +id: GO:2001044 +name: regulation of integrin-mediated signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] +synonym: "regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0007229 ! integrin-mediated signaling pathway + +[Term] +id: GO:2001045 +name: negative regulation of integrin-mediated signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] +synonym: "negative regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway +relationship: negatively_regulates GO:0007229 ! integrin-mediated signaling pathway + +[Term] +id: GO:2001046 +name: positive regulation of integrin-mediated signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of integrin-mediated signaling pathway." [GOC:obol] +synonym: "positive regulation of integrin-mediated signalling pathway" EXACT [GOC:obol] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2001044 ! regulation of integrin-mediated signaling pathway +relationship: positively_regulates GO:0007229 ! integrin-mediated signaling pathway + +[Term] +id: GO:2001049 +name: regulation of tendon cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of tendon cell differentiation." [GOC:obol] +synonym: "regulation of muscle attachment cell differentiation" EXACT [GOC:obol] +synonym: "regulation of tenocyte differentiation" RELATED [GOC:obol] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0035990 ! tendon cell differentiation + +[Term] +id: GO:2001050 +name: negative regulation of tendon cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of tendon cell differentiation." [GOC:obol] +synonym: "negative regulation of muscle attachment cell differentiation" EXACT [GOC:obol] +synonym: "negative regulation of tenocyte differentiation" RELATED [GOC:obol] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:2001049 ! regulation of tendon cell differentiation +relationship: negatively_regulates GO:0035990 ! tendon cell differentiation + +[Term] +id: GO:2001051 +name: positive regulation of tendon cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of tendon cell differentiation." [GOC:obol] +synonym: "positive regulation of muscle attachment cell differentiation" EXACT [GOC:obol] +synonym: "positive regulation of tenocyte differentiation" RELATED [GOC:obol] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:2001049 ! regulation of tendon cell differentiation +relationship: positively_regulates GO:0035990 ! tendon cell differentiation + +[Term] +id: GO:2001053 +name: regulation of mesenchymal cell apoptotic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "regulation of mesenchymal cell apoptosis" NARROW [] +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0097152 ! mesenchymal cell apoptotic process + +[Term] +id: GO:2001054 +name: negative regulation of mesenchymal cell apoptotic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "negative regulation of mesenchymal cell apoptosis" NARROW [] +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process +relationship: negatively_regulates GO:0097152 ! mesenchymal cell apoptotic process + +[Term] +id: GO:2001055 +name: positive regulation of mesenchymal cell apoptotic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol] +synonym: "positive regulation of mesenchymal cell apoptosis" NARROW [] +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:2001053 ! regulation of mesenchymal cell apoptotic process +relationship: positively_regulates GO:0097152 ! mesenchymal cell apoptotic process + +[Term] +id: GO:2001056 +name: positive regulation of cysteine-type endopeptidase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol] +synonym: "positive regulation of lysosomal cysteine-type endopeptidase" RELATED [GOC:obol] +synonym: "positive regulation of thiol endopeptidase activity" EXACT [GOC:obol] +is_a: GO:0010950 ! positive regulation of endopeptidase activity +is_a: GO:2000116 ! regulation of cysteine-type endopeptidase activity + +[Term] +id: GO:2001057 +name: reactive nitrogen species metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a reactive nitrogen species." [GOC:obol] +synonym: "reactive nitrogen species metabolism" EXACT [GOC:obol] +synonym: "RNS metabolic process" EXACT [GOC:obol] +synonym: "RNS metabolism" EXACT [GOC:obol] +is_a: GO:0006807 ! nitrogen compound metabolic process + +[Term] +id: GO:2001058 +name: D-tagatose 6-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a D-tagatose 6-phosphate." [GOC:obol] +synonym: "D-tagatose 6-phosphate metabolism" EXACT [GOC:obol] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:2001059 +name: D-tagatose 6-phosphate catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a D-tagatose 6-phosphate." [GOC:mengo_curators] +synonym: "D-tagatose 6-phosphate catabolism" EXACT [GOC:obol] +xref: UniPathway:UPA00704 +is_a: GO:0046434 ! organophosphate catabolic process +is_a: GO:1901136 ! carbohydrate derivative catabolic process +is_a: GO:2001058 ! D-tagatose 6-phosphate metabolic process + +[Term] +id: GO:2001060 +name: D-glycero-D-manno-heptose 7-phosphate metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators] +synonym: "D-glycero-D-manno-heptose 7-phosphate metabolism" EXACT [GOC:obol] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:1901135 ! carbohydrate derivative metabolic process + +[Term] +id: GO:2001061 +name: D-glycero-D-manno-heptose 7-phosphate biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate." [GOC:mengo_curators] +synonym: "D-glycero-D-manno-heptose 7-phosphate biosynthesis" EXACT [GOC:obol] +xref: UniPathway:UPA00041 +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:2001060 ! D-glycero-D-manno-heptose 7-phosphate metabolic process + +[Term] +id: GO:2001062 +name: xylan binding +namespace: molecular_function +def: "Binding to xylan." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001063 +name: glucomannan binding +namespace: molecular_function +def: "Binding to glucomannan." [GOC:mengo_curators] +is_a: GO:0010297 ! heteropolysaccharide binding + +[Term] +id: GO:2001064 +name: cellooligosaccharide binding +namespace: molecular_function +def: "Binding to cellooligosaccharide." [GOC:mengo_curators] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:2001065 +name: mannan binding +namespace: molecular_function +def: "Binding to mannan." [GOC:mengo_curators] +synonym: "mannoglycan binding" RELATED [GOC:obol] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001066 +name: amylopectin binding +namespace: molecular_function +def: "Binding to amylopectin." [GOC:mengo_curators] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:2001067 +name: pullulan binding +namespace: molecular_function +def: "Binding to pullulan." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001068 +name: arabinoxylan binding +namespace: molecular_function +def: "Binding to arabinoxylan." [GOC:mengo_curators] +is_a: GO:2001062 ! xylan binding + +[Term] +id: GO:2001069 +name: glycogen binding +namespace: molecular_function +def: "Binding to glycogen." [GOC:mengo_curators] +synonym: "animal starch binding" RELATED [GOC:obol] +synonym: "liver starch binding" RELATED [GOC:obol] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001070 +name: starch binding +namespace: molecular_function +def: "Binding to starch." [GOC:mengo_curators] +synonym: "amidon binding" RELATED [GOC:obol] +synonym: "amylum binding" RELATED [GOC:obol] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001071 +name: maltoheptaose binding +namespace: molecular_function +def: "Binding to maltoheptaose." [GOC:mengo_curators] +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:2001072 +name: galactomannan binding +namespace: molecular_function +def: "Binding to galactomannan." [GOC:mengo_curators] +is_a: GO:0010297 ! heteropolysaccharide binding + +[Term] +id: GO:2001073 +name: cyclodextrin binding +namespace: molecular_function +def: "Binding to cyclodextrin." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding +is_a: GO:0070492 ! oligosaccharide binding + +[Term] +id: GO:2001074 +name: regulation of metanephric ureteric bud development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] +is_a: GO:0072215 ! regulation of metanephros development +relationship: regulates GO:0035502 ! metanephric part of ureteric bud development + +[Term] +id: GO:2001075 +name: negative regulation of metanephric ureteric bud development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] +is_a: GO:0051093 ! negative regulation of developmental process +is_a: GO:2001074 ! regulation of metanephric ureteric bud development +relationship: negatively_regulates GO:0035502 ! metanephric part of ureteric bud development + +[Term] +id: GO:2001076 +name: positive regulation of metanephric ureteric bud development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of metanephric ureteric bud development." [GOC:obol] +is_a: GO:0051094 ! positive regulation of developmental process +is_a: GO:2001074 ! regulation of metanephric ureteric bud development +relationship: positively_regulates GO:0035502 ! metanephric part of ureteric bud development + +[Term] +id: GO:2001077 +name: (1->3),(1->4)-beta-glucan binding +namespace: molecular_function +def: "Binding to (1->3),(1->4)-beta-glucan." [GOC:mengo_curators] +synonym: "(1,3),(1,4)-beta-glucan binding" EXACT [] +synonym: "1->3,1->4-beta-glucan binding" EXACT [] +synonym: "beta-(1,3),(1,4)-glucan binding" EXACT [] +synonym: "beta-(1->3),(1->4)-glucan binding" EXACT [] +synonym: "beta-1,3-1,4-glucan binding" EXACT [] +synonym: "beta-1->3,1->4-glucan binding" EXACT [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001078 +name: (1->6)-beta-D-glucan binding +namespace: molecular_function +def: "Binding to (1->6)-beta-D-glucan." [GOC:mengo_curators] +synonym: "(1,6)-beta-D-glucan binding" EXACT [] +synonym: "1,6-beta-D-glucan binding" EXACT [] +synonym: "1->6-beta-D-glucan binding" EXACT [] +synonym: "beta-(1,6)-D-glucan binding" EXACT [] +synonym: "beta-(1->6)-D-glucan binding" EXACT [] +synonym: "beta-1,6-D-glucan binding" EXACT [] +synonym: "beta-1->6-D-glucan binding" EXACT [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001079 +name: beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding +namespace: molecular_function +def: "Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc." [GOC:mengo_curators] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:2001080 +name: chitosan binding +namespace: molecular_function +def: "Binding to chitosan." [GOC:mengo_curators] +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:2001081 +name: (1->4)-beta-D-galactan binding +namespace: molecular_function +def: "Binding to (1->4)-beta-D-galactan." [GOC:mengo_curators] +synonym: "(1,4)-beta-D-galactan binding" EXACT [] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001082 +name: inulin binding +namespace: molecular_function +def: "Binding to inulin." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001083 +name: alpha-D-glucan binding +namespace: molecular_function +def: "Binding to alpha-D-glucan." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001084 +name: L-arabinofuranose binding +namespace: molecular_function +def: "Binding to L-arabinofuranose." [GOC:mengo_curators] +is_a: GO:0048029 ! monosaccharide binding + +[Term] +id: GO:2001085 +name: arabinogalactan binding +namespace: molecular_function +def: "Binding to arabinogalactan." [GOC:mengo_curators] +is_a: GO:0030247 ! polysaccharide binding + +[Term] +id: GO:2001086 +name: laminarabiose transport +namespace: biological_process +def: "The directed movement of a laminarabioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:2001087 +name: sophorose transport +namespace: biological_process +def: "The directed movement of a sophoroseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015766 ! disaccharide transport + +[Term] +id: GO:2001088 +name: trisaccharide transport +namespace: biological_process +def: "The directed movement of a trisaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:2001089 +name: maltotriose transport +namespace: biological_process +def: "The directed movement of a maltotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001090 +name: maltotriulose transport +namespace: biological_process +def: "The directed movement of a maltotriuloseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001091 +name: nigerotriose transport +namespace: biological_process +def: "The directed movement of a nigerotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001092 +name: arabinotriose transport +namespace: biological_process +def: "The directed movement of an arabinotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001093 +name: galactotriose transport +namespace: biological_process +def: "The directed movement of a galactotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015766 ! disaccharide transport +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001094 +name: xylotriose transport +namespace: biological_process +def: "The directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001095 +name: mannotriose transport +namespace: biological_process +def: "The directed movement of a mannotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001096 +name: cellotriose transport +namespace: biological_process +def: "The directed movement of a cellotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001097 +name: laminaritriose transport +namespace: biological_process +def: "The directed movement of a laminaritrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001088 ! trisaccharide transport + +[Term] +id: GO:2001098 +name: tetrasaccharide transport +namespace: biological_process +def: "The directed movement of a tetrasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:2001099 +name: maltotetraose transport +namespace: biological_process +def: "The directed movement of a maltotetraoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001098 ! tetrasaccharide transport + +[Term] +id: GO:2001100 +name: pentasaccharide transport +namespace: biological_process +def: "The directed movement of a pentasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:2001101 +name: maltopentaose transport +namespace: biological_process +def: "The directed movement of a maltopentaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001100 ! pentasaccharide transport + +[Term] +id: GO:2001102 +name: hexasaccharide transport +namespace: biological_process +def: "The directed movement of a hexasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:2001103 +name: maltohexaose transport +namespace: biological_process +def: "The directed movement of a maltohexaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001102 ! hexasaccharide transport + +[Term] +id: GO:2001104 +name: heptasaccharide transport +namespace: biological_process +def: "The directed movement of a heptasaccharideacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:0015772 ! oligosaccharide transport + +[Term] +id: GO:2001105 +name: maltoheptaose transport +namespace: biological_process +def: "The directed movement of a maltoheptaoseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mengo_curators] +is_a: GO:2001104 ! heptasaccharide transport + +[Term] +id: GO:2001106 +name: regulation of Rho guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] +synonym: "regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] +synonym: "regulation of RhoGEF" EXACT [GOC:obol] +is_a: GO:1905097 ! regulation of guanyl-nucleotide exchange factor activity + +[Term] +id: GO:2001107 +name: negative regulation of Rho guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] +synonym: "negative regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] +synonym: "negative regulation of RhoGEF" EXACT [GOC:obol] +is_a: GO:1905098 ! negative regulation of guanyl-nucleotide exchange factor activity + +[Term] +id: GO:2001108 +name: positive regulation of Rho guanyl-nucleotide exchange factor activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." [GOC:obol] +synonym: "positive regulation of Rho guanine nucleotide exchange factor" EXACT [GOC:obol] +synonym: "positive regulation of RhoGEF" EXACT [GOC:obol] +is_a: GO:1905099 ! positive regulation of guanyl-nucleotide exchange factor activity + +[Term] +id: GO:2001109 +name: regulation of lens epithelial cell proliferation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] +is_a: GO:0050678 ! regulation of epithelial cell proliferation +relationship: regulates GO:0097166 ! lens epithelial cell proliferation + +[Term] +id: GO:2001110 +name: negative regulation of lens epithelial cell proliferation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] +is_a: GO:0050680 ! negative regulation of epithelial cell proliferation +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2001109 ! regulation of lens epithelial cell proliferation +relationship: negatively_regulates GO:0097166 ! lens epithelial cell proliferation + +[Term] +id: GO:2001111 +name: positive regulation of lens epithelial cell proliferation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lens epithelial cell proliferation." [GOC:obol] +is_a: GO:0050679 ! positive regulation of epithelial cell proliferation +is_a: GO:2001109 ! regulation of lens epithelial cell proliferation +relationship: positively_regulates GO:0097166 ! lens epithelial cell proliferation + +[Term] +id: GO:2001112 +name: regulation of cellular response to hepatocyte growth factor stimulus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] +synonym: "regulation of cellular response to HGF stimulus" EXACT [GOC:obol] +is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus +relationship: regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus + +[Term] +id: GO:2001113 +name: negative regulation of cellular response to hepatocyte growth factor stimulus +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] +synonym: "negative regulation of cellular response to HGF stimulus" EXACT [GOC:obol] +is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus +is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus +relationship: negatively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus + +[Term] +id: GO:2001114 +name: positive regulation of cellular response to hepatocyte growth factor stimulus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cellular response to hepatocyte growth factor stimulus." [GOC:obol] +synonym: "positive regulation of cellular response to HGF stimulus" EXACT [GOC:obol] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2001112 ! regulation of cellular response to hepatocyte growth factor stimulus +relationship: positively_regulates GO:0035729 ! cellular response to hepatocyte growth factor stimulus + +[Term] +id: GO:2001115 +name: methanopterin-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a methanopterin." [GOC:mengo_curators] +synonym: "methanopterin metabolism" EXACT [GOC:obol] +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process +is_a: GO:0042558 ! pteridine-containing compound metabolic process + +[Term] +id: GO:2001116 +name: methanopterin-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methanopterin." [GOC:mengo_curators] +synonym: "methanopterin biosynthesis" EXACT [GOC:obol] +is_a: GO:0042559 ! pteridine-containing compound biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:2001115 ! methanopterin-containing compound metabolic process + +[Term] +id: GO:2001117 +name: tetrahydromethanopterin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a tetrahydromethanopterin." [GOC:mengo_curators] +synonym: "tetrahydromethanopterin metabolism" EXACT [GOC:obol] +is_a: GO:2001115 ! methanopterin-containing compound metabolic process + +[Term] +id: GO:2001118 +name: tetrahydromethanopterin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin." [GOC:mengo_curators] +synonym: "tetrahydromethanopterin biosynthesis" EXACT [GOC:obol] +is_a: GO:2001116 ! methanopterin-containing compound biosynthetic process +is_a: GO:2001117 ! tetrahydromethanopterin metabolic process + +[Term] +id: GO:2001119 +name: methanofuran metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a methanofuran." [GOC:mengo_curators] +synonym: "methanofuran metabolism" EXACT [GOC:obol] +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:2001120 +name: methanofuran biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methanofuran." [GOC:mengo_curators] +synonym: "methanofuran biosynthesis" EXACT [GOC:obol] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:2001119 ! methanofuran metabolic process + +[Term] +id: GO:2001121 +name: coenzyme gamma-F420-2 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a coenzyme gamma-F420-2." [GOC:mengo_curators] +synonym: "coenzyme gamma-F420-2 biosynthesis" EXACT [GOC:obol] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0052649 ! coenzyme gamma-F420-2 metabolic process +is_a: GO:0072351 ! tricarboxylic acid biosynthetic process +is_a: GO:0090407 ! organophosphate biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:1901566 ! organonitrogen compound biosynthetic process + +[Term] +id: GO:2001122 +name: maltoheptaose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a maltoheptaose." [GOC:mengo_curators] +synonym: "maltoheptaose metabolism" EXACT [GOC:obol] +is_a: GO:0009311 ! oligosaccharide metabolic process + +[Term] +id: GO:2001123 +name: maltoheptaose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a maltoheptaose." [GOC:mengo_curators] +synonym: "maltoheptaose catabolism" EXACT [GOC:obol] +is_a: GO:0009313 ! oligosaccharide catabolic process +is_a: GO:2001122 ! maltoheptaose metabolic process + +[Term] +id: GO:2001124 +name: regulation of translational frameshifting +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of translational frameshifting." [GOC:obol] +is_a: GO:0006448 ! regulation of translational elongation +relationship: regulates GO:0006452 ! translational frameshifting + +[Term] +id: GO:2001125 +name: negative regulation of translational frameshifting +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of translational frameshifting." [GOC:obol] +is_a: GO:0045900 ! negative regulation of translational elongation +is_a: GO:2001124 ! regulation of translational frameshifting +relationship: negatively_regulates GO:0006452 ! translational frameshifting + +[Term] +id: GO:2001126 +name: positive regulation of translational frameshifting +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of translational frameshifting." [GOC:obol] +is_a: GO:0045901 ! positive regulation of translational elongation +is_a: GO:2001124 ! regulation of translational frameshifting +relationship: positively_regulates GO:0006452 ! translational frameshifting + +[Term] +id: GO:2001127 +name: methane biosynthetic process from formic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a formic acid." [GOC:mengo_curators] +is_a: GO:0015942 ! formate metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001128 +name: methane biosynthetic process from methylamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a methylamine." [GOC:mengo_curators] +is_a: GO:0015948 ! methanogenesis +is_a: GO:0030416 ! methylamine metabolic process + +[Term] +id: GO:2001129 +name: methane biosynthetic process from dimethylamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethylamine." [GOC:mengo_curators] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001130 +name: methane biosynthetic process from trimethylamine +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a trimethylamine." [GOC:mengo_curators] +is_a: GO:0009308 ! amine metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001131 +name: methane biosynthetic process from dimethyl sulfide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a dimethyl sulfide." [GOC:mengo_curators] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001132 +name: methane biosynthetic process from 3-(methylthio)propionic acid +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a 3-(methylthio)propionic acid." [GOC:mengo_curators] +is_a: GO:0006631 ! fatty acid metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001133 +name: methane biosynthetic process from methanethiol +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a methanethiol." [GOC:mengo_curators] +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001134 +name: methane biosynthetic process from carbon monoxide +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a methane from a carbon monoxide." [GOC:mengo_curators] +is_a: GO:0015948 ! methanogenesis + +[Term] +id: GO:2001135 +name: regulation of endocytic recycling +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of endocytic recycling." [GOC:obol] +synonym: "regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] +is_a: GO:0032386 ! regulation of intracellular transport +is_a: GO:0060627 ! regulation of vesicle-mediated transport +relationship: regulates GO:0032456 ! endocytic recycling + +[Term] +id: GO:2001136 +name: negative regulation of endocytic recycling +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling." [GOC:obol] +synonym: "negative regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:2001135 ! regulation of endocytic recycling +relationship: negatively_regulates GO:0032456 ! endocytic recycling + +[Term] +id: GO:2001137 +name: positive regulation of endocytic recycling +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of endocytic recycling." [GOC:obol] +synonym: "positive regulation of retrograde transport of endocytic vesicles" RELATED [GOC:obol] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:2001135 ! regulation of endocytic recycling +relationship: positively_regulates GO:0032456 ! endocytic recycling + +[Term] +id: GO:2001138 +name: regulation of phospholipid transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phospholipid transport." [GOC:obol] +is_a: GO:0032368 ! regulation of lipid transport +relationship: regulates GO:0015914 ! phospholipid transport + +[Term] +id: GO:2001139 +name: negative regulation of phospholipid transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid transport." [GOC:obol] +is_a: GO:0032369 ! negative regulation of lipid transport +is_a: GO:2001138 ! regulation of phospholipid transport +relationship: negatively_regulates GO:0015914 ! phospholipid transport + +[Term] +id: GO:2001140 +name: positive regulation of phospholipid transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phospholipid transport." [GOC:obol] +is_a: GO:0032370 ! positive regulation of lipid transport +is_a: GO:2001138 ! regulation of phospholipid transport +relationship: positively_regulates GO:0015914 ! phospholipid transport + +[Term] +id: GO:2001141 +name: regulation of RNA biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] +synonym: "regulation of RNA anabolism" EXACT [GOC:obol] +synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] +synonym: "regulation of RNA formation" EXACT [GOC:obol] +synonym: "regulation of RNA synthesis" EXACT [GOC:obol] +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process +is_a: GO:0051252 ! regulation of RNA metabolic process +relationship: regulates GO:0032774 ! RNA biosynthetic process + +[Term] +id: GO:2001142 +name: nicotinate transport +namespace: biological_process +def: "The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol] +is_a: GO:0015718 ! monocarboxylic acid transport +is_a: GO:0015849 ! organic acid transport +is_a: GO:0071705 ! nitrogen compound transport + +[Term] +id: GO:2001143 +name: N-methylnicotinate transport +namespace: biological_process +def: "The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:obol] +is_a: GO:0015695 ! organic cation transport +is_a: GO:0015697 ! quaternary ammonium group transport + +[Term] +id: GO:2001144 +name: regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] +is_a: GO:0010921 ! regulation of phosphatase activity + +[Term] +id: GO:2001145 +name: negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] +is_a: GO:0010923 ! negative regulation of phosphatase activity +is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity + +[Term] +id: GO:2001146 +name: positive regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity." [GOC:obol] +is_a: GO:0010922 ! positive regulation of phosphatase activity +is_a: GO:2001144 ! regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity + +[Term] +id: GO:2001147 +name: camalexin binding +namespace: molecular_function +def: "Binding to camalexin." [GOC:obol] +synonym: "3-(1,3-thiazol-2-yl)-1H-indole binding" EXACT [GOC:obol] +is_a: GO:0097159 ! organic cyclic compound binding +is_a: GO:1901363 ! heterocyclic compound binding +is_a: GO:1901681 ! sulfur compound binding + +[Term] +id: GO:2001148 +name: regulation of dipeptide transmembrane transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] +synonym: "regulation of dipeptide membrane transport" EXACT [] +is_a: GO:0034762 ! regulation of transmembrane transport +is_a: GO:0090089 ! regulation of dipeptide transport +relationship: regulates GO:0035442 ! dipeptide transmembrane transport + +[Term] +id: GO:2001149 +name: negative regulation of dipeptide transmembrane transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] +synonym: "negative regulation of dipeptide membrane transport" EXACT [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:2000879 ! negative regulation of dipeptide transport +is_a: GO:2001148 ! regulation of dipeptide transmembrane transport +relationship: negatively_regulates GO:0035442 ! dipeptide transmembrane transport + +[Term] +id: GO:2001150 +name: positive regulation of dipeptide transmembrane transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport." [GOC:obol] +synonym: "positive regulation of dipeptide membrane transport" EXACT [] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:2000880 ! positive regulation of dipeptide transport +is_a: GO:2001148 ! regulation of dipeptide transmembrane transport +relationship: positively_regulates GO:0035442 ! dipeptide transmembrane transport + +[Term] +id: GO:2001151 +name: regulation of renal water transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of renal water transport." [GOC:obol] +is_a: GO:0050878 ! regulation of body fluid levels +is_a: GO:0051049 ! regulation of transport +is_a: GO:0098801 ! regulation of renal system process +relationship: regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001152 +name: negative regulation of renal water transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport." [GOC:obol] +is_a: GO:0051051 ! negative regulation of transport +is_a: GO:0051241 ! negative regulation of multicellular organismal process +is_a: GO:2001151 ! regulation of renal water transport +relationship: negatively_regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001153 +name: positive regulation of renal water transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of renal water transport." [GOC:obol] +is_a: GO:0051050 ! positive regulation of transport +is_a: GO:0051240 ! positive regulation of multicellular organismal process +is_a: GO:2001151 ! regulation of renal water transport +relationship: positively_regulates GO:0003097 ! renal water transport + +[Term] +id: GO:2001154 +name: regulation of glycolytic fermentation to ethanol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] +synonym: "regulation of ethanol fermentation" EXACT [GOC:obol] +synonym: "regulation of glucose fermentation to ethanol" EXACT [GOC:obol] +is_a: GO:0043465 ! regulation of fermentation +is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: regulates GO:0019655 ! glycolytic fermentation to ethanol + +[Term] +id: GO:2001155 +name: negative regulation of glycolytic fermentation to ethanol +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] +synonym: "negative regulation of ethanol fermentation" EXACT [GOC:obol] +synonym: "negative regulation of glucose fermentation to ethanol" EXACT [GOC:obol] +is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process +is_a: GO:1901003 ! negative regulation of fermentation +is_a: GO:1903579 ! negative regulation of ATP metabolic process +is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol +relationship: negatively_regulates GO:0019655 ! glycolytic fermentation to ethanol + +[Term] +id: GO:2001156 +name: regulation of proline catabolic process to glutamate +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] +synonym: "regulation of proline breakdown to glutamate" EXACT [GOC:obol] +synonym: "regulation of proline degradation to glutamate" EXACT [GOC:obol] +synonym: "regulation of proline oxidation" RELATED [GOC:obol] +is_a: GO:0033241 ! regulation of cellular amine catabolic process +is_a: GO:2000211 ! regulation of glutamate metabolic process +is_a: GO:2000214 ! regulation of proline metabolic process +relationship: regulates GO:0010133 ! proline catabolic process to glutamate + +[Term] +id: GO:2001157 +name: negative regulation of proline catabolic process to glutamate +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] +synonym: "negative regulation of proline breakdown to glutamate" EXACT [GOC:obol] +synonym: "negative regulation of proline degradation to glutamate" EXACT [GOC:obol] +synonym: "negative regulation of proline oxidation" RELATED [GOC:obol] +is_a: GO:0033242 ! negative regulation of cellular amine catabolic process +is_a: GO:2000212 ! negative regulation of glutamate metabolic process +is_a: GO:2000215 ! negative regulation of proline metabolic process +is_a: GO:2001156 ! regulation of proline catabolic process to glutamate +relationship: negatively_regulates GO:0010133 ! proline catabolic process to glutamate + +[Term] +id: GO:2001158 +name: positive regulation of proline catabolic process to glutamate +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate." [GOC:obol] +synonym: "positive regulation of proline breakdown to glutamate" EXACT [GOC:obol] +synonym: "positive regulation of proline degradation to glutamate" EXACT [GOC:obol] +synonym: "positive regulation of proline oxidation" RELATED [GOC:obol] +is_a: GO:0033243 ! positive regulation of cellular amine catabolic process +is_a: GO:2000213 ! positive regulation of glutamate metabolic process +is_a: GO:2000216 ! positive regulation of proline metabolic process +is_a: GO:2001156 ! regulation of proline catabolic process to glutamate +relationship: positively_regulates GO:0010133 ! proline catabolic process to glutamate + +[Term] +id: GO:2001159 +name: regulation of protein localization by the Cvt pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization by the Cvt pathway." [GOC:obol] +synonym: "regulation of cytoplasm to vacuole targeting" EXACT [GOC:obol] +synonym: "regulation of cytoplasm-to-vacuole targeting" EXACT [GOC:obol] +is_a: GO:1903335 ! regulation of vacuolar transport +is_a: GO:1903533 ! regulation of protein targeting +relationship: regulates GO:0032258 ! cytoplasm to vacuole transport by the Cvt pathway + +[Term] +id: GO:2001160 +name: regulation of histone H3-K79 methylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] +synonym: "regulation of histone H3 K79 methylation" EXACT [GOC:obol] +synonym: "regulation of histone H3K79me" EXACT [GOC:obol] +synonym: "regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] +is_a: GO:0031060 ! regulation of histone methylation +relationship: regulates GO:0034729 ! histone H3-K79 methylation + +[Term] +id: GO:2001161 +name: negative regulation of histone H3-K79 methylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] +synonym: "negative regulation of histone H3 K79 methylation" EXACT [GOC:obol] +synonym: "negative regulation of histone H3K79me" EXACT [GOC:obol] +synonym: "negative regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] +is_a: GO:0031061 ! negative regulation of histone methylation +is_a: GO:2001160 ! regulation of histone H3-K79 methylation +relationship: negatively_regulates GO:0034729 ! histone H3-K79 methylation + +[Term] +id: GO:2001162 +name: positive regulation of histone H3-K79 methylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K79 methylation." [PMID:12876294] +synonym: "positive regulation of histone H3 K79 methylation" EXACT [GOC:obol] +synonym: "positive regulation of histone H3K79me" EXACT [GOC:obol] +synonym: "positive regulation of histone lysine H3 K79 methylation" EXACT [GOC:obol] +is_a: GO:0031062 ! positive regulation of histone methylation +is_a: GO:2001160 ! regulation of histone H3-K79 methylation +relationship: positively_regulates GO:0034729 ! histone H3-K79 methylation + +[Term] +id: GO:2001163 +name: regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] +is_a: GO:1901407 ! regulation of phosphorylation of RNA polymerase II C-terminal domain +relationship: regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + +[Term] +id: GO:2001164 +name: negative regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] +is_a: GO:1901408 ! negative regulation of phosphorylation of RNA polymerase II C-terminal domain +is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +relationship: negatively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + +[Term] +id: GO:2001165 +name: positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues." [PMID:15149594] +is_a: GO:1901409 ! positive regulation of phosphorylation of RNA polymerase II C-terminal domain +is_a: GO:2001163 ! regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues +relationship: positively_regulates GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues + +[Term] +id: GO:2001166 +name: regulation of histone H2B ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] +is_a: GO:0033182 ! regulation of histone ubiquitination +relationship: regulates GO:0033523 ! histone H2B ubiquitination + +[Term] +id: GO:2001167 +name: negative regulation of histone H2B ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] +is_a: GO:0033183 ! negative regulation of histone ubiquitination +is_a: GO:2001166 ! regulation of histone H2B ubiquitination +relationship: negatively_regulates GO:0033523 ! histone H2B ubiquitination + +[Term] +id: GO:2001168 +name: positive regulation of histone H2B ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination." [PMID:12876293] +is_a: GO:0033184 ! positive regulation of histone ubiquitination +is_a: GO:2001166 ! regulation of histone H2B ubiquitination +relationship: positively_regulates GO:0033523 ! histone H2B ubiquitination + +[Term] +id: GO:2001169 +name: regulation of ATP biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] +synonym: "regulation of ATP anabolism" EXACT [GOC:obol] +synonym: "regulation of ATP biosynthesis" EXACT [GOC:obol] +synonym: "regulation of ATP formation" EXACT [GOC:obol] +synonym: "regulation of ATP regeneration" RELATED [GOC:obol] +synonym: "regulation of ATP synthesis" EXACT [GOC:obol] +is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process +is_a: GO:1903578 ! regulation of ATP metabolic process +relationship: regulates GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:2001170 +name: negative regulation of ATP biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] +synonym: "negative regulation of ATP anabolism" EXACT [GOC:obol] +synonym: "negative regulation of ATP biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of ATP formation" EXACT [GOC:obol] +synonym: "negative regulation of ATP regeneration" RELATED [GOC:obol] +synonym: "negative regulation of ATP synthesis" EXACT [GOC:obol] +is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process +is_a: GO:1903579 ! negative regulation of ATP metabolic process +is_a: GO:2001169 ! regulation of ATP biosynthetic process +relationship: negatively_regulates GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:2001171 +name: positive regulation of ATP biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process." [GOC:obol] +synonym: "positive regulation of ATP anabolism" EXACT [GOC:obol] +synonym: "positive regulation of ATP biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of ATP formation" EXACT [GOC:obol] +synonym: "positive regulation of ATP regeneration" RELATED [GOC:obol] +synonym: "positive regulation of ATP synthesis" EXACT [GOC:obol] +is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process +is_a: GO:1903580 ! positive regulation of ATP metabolic process +is_a: GO:2001169 ! regulation of ATP biosynthetic process +relationship: positively_regulates GO:0006754 ! ATP biosynthetic process + +[Term] +id: GO:2001172 +name: positive regulation of glycolytic fermentation to ethanol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glucose catabolic process to ethanol." [GOC:obol] +synonym: "positive regulation of ethanol fermentation" EXACT [GOC:obol] +synonym: "positive regulation of glucose fermentation to ethanol" EXACT [GOC:obol] +is_a: GO:0031325 ! positive regulation of cellular metabolic process +is_a: GO:1903580 ! positive regulation of ATP metabolic process +is_a: GO:2001154 ! regulation of glycolytic fermentation to ethanol +relationship: positively_regulates GO:0019655 ! glycolytic fermentation to ethanol + +[Term] +id: GO:2001173 +name: regulation of histone H2B conserved C-terminal lysine ubiquitination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] +synonym: "regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] +synonym: "regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] +synonym: "regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] +is_a: GO:2001166 ! regulation of histone H2B ubiquitination +relationship: regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination + +[Term] +id: GO:2001174 +name: negative regulation of histone H2B conserved C-terminal lysine ubiquitination +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] +synonym: "negative regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] +synonym: "negative regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] +synonym: "negative regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] +is_a: GO:2001167 ! negative regulation of histone H2B ubiquitination +is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination +relationship: negatively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination + +[Term] +id: GO:2001175 +name: positive regulation of histone H2B conserved C-terminal lysine ubiquitination +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." [PMID:17576814] +synonym: "positive regulation of budding yeast H2B K123 ubiquitination" RELATED [GOC:obol] +synonym: "positive regulation of fission yeast H2B K119 ubiquitination" RELATED [GOC:obol] +synonym: "positive regulation of mammalian H2B K120 ubiquitination" RELATED [GOC:obol] +is_a: GO:2001168 ! positive regulation of histone H2B ubiquitination +is_a: GO:2001173 ! regulation of histone H2B conserved C-terminal lysine ubiquitination +relationship: positively_regulates GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination + +[Term] +id: GO:2001176 +name: regulation of mediator complex assembly +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of mediator complex assembly." [GOC:obol] +is_a: GO:0043254 ! regulation of protein-containing complex assembly +relationship: regulates GO:0036034 ! mediator complex assembly + +[Term] +id: GO:2001177 +name: negative regulation of mediator complex assembly +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of mediator complex assembly." [GOC:obol] +is_a: GO:0031333 ! negative regulation of protein-containing complex assembly +is_a: GO:2001176 ! regulation of mediator complex assembly +relationship: negatively_regulates GO:0036034 ! mediator complex assembly + +[Term] +id: GO:2001178 +name: positive regulation of mediator complex assembly +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of mediator complex assembly." [GOC:obol] +is_a: GO:0031334 ! positive regulation of protein-containing complex assembly +is_a: GO:2001176 ! regulation of mediator complex assembly +relationship: positively_regulates GO:0036034 ! mediator complex assembly + +[Term] +id: GO:2001185 +name: regulation of CD8-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046634 ! regulation of alpha-beta T cell activation +relationship: regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation + +[Term] +id: GO:2001186 +name: negative regulation of CD8-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046636 ! negative regulation of alpha-beta T cell activation +is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation +relationship: negatively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation + +[Term] +id: GO:2001187 +name: positive regulation of CD8-positive, alpha-beta T cell activation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation." [GOC:obol] +is_a: GO:0046635 ! positive regulation of alpha-beta T cell activation +is_a: GO:2001185 ! regulation of CD8-positive, alpha-beta T cell activation +relationship: positively_regulates GO:0036037 ! CD8-positive, alpha-beta T cell activation + +[Term] +id: GO:2001188 +name: regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] +synonym: "regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0050776 ! regulation of immune response +is_a: GO:0050863 ! regulation of T cell activation +relationship: regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + +[Term] +id: GO:2001189 +name: negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] +synonym: "negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:0050868 ! negative regulation of T cell activation +is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +relationship: negatively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + +[Term] +id: GO:2001190 +name: positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell." [GOC:obol] +synonym: "positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +synonym: "positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [GOC:obol] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:0050870 ! positive regulation of T cell activation +is_a: GO:2001188 ! regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell +relationship: positively_regulates GO:0002291 ! T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell + +[Term] +id: GO:2001191 +name: regulation of gamma-delta T cell activation involved in immune response +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] +synonym: "regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] +synonym: "regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] +synonym: "regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] +synonym: "regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] +is_a: GO:0002697 ! regulation of immune effector process +is_a: GO:0046643 ! regulation of gamma-delta T cell activation +is_a: GO:0050776 ! regulation of immune response +relationship: regulates GO:0002290 ! gamma-delta T cell activation involved in immune response + +[Term] +id: GO:2001192 +name: negative regulation of gamma-delta T cell activation involved in immune response +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] +synonym: "negative regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] +synonym: "negative regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] +synonym: "negative regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] +synonym: "negative regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] +is_a: GO:0002698 ! negative regulation of immune effector process +is_a: GO:0046644 ! negative regulation of gamma-delta T cell activation +is_a: GO:0050777 ! negative regulation of immune response +is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response +relationship: negatively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response + +[Term] +id: GO:2001193 +name: positive regulation of gamma-delta T cell activation involved in immune response +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response." [GOC:obol] +synonym: "positive regulation of gamma-delta T cell activation during immune response" RELATED [GOC:obol] +synonym: "positive regulation of gamma-delta T lymphocyte activation during immune response" RELATED [GOC:obol] +synonym: "positive regulation of gamma-delta T-cell activation during immune response" RELATED [GOC:obol] +synonym: "positive regulation of gamma-delta T-lymphocyte activation during immune response" RELATED [GOC:obol] +is_a: GO:0002699 ! positive regulation of immune effector process +is_a: GO:0046645 ! positive regulation of gamma-delta T cell activation +is_a: GO:0050778 ! positive regulation of immune response +is_a: GO:2001191 ! regulation of gamma-delta T cell activation involved in immune response +relationship: positively_regulates GO:0002290 ! gamma-delta T cell activation involved in immune response + +[Term] +id: GO:2001194 +name: regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] +synonym: "regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] +synonym: "regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] +is_a: GO:1902986 ! regulation of lysine biosynthetic process via aminoadipic acid +relationship: regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine + +[Term] +id: GO:2001195 +name: negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] +synonym: "negative regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] +synonym: "negative regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] +is_a: GO:1902987 ! negative regulation of lysine biosynthetic process via aminoadipic acid +is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine +relationship: negatively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine + +[Term] +id: GO:2001196 +name: positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." [GOC:obol] +synonym: "positive regulation of lysine biosynthesis via aminoadipic acid and saccharopine" EXACT [GOC:obol] +synonym: "positive regulation of lysine biosynthetic process via aminoadipic acid and saccharopine" EXACT [GOC:obol] +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +is_a: GO:2001194 ! regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine +relationship: positively_regulates GO:0051975 ! lysine biosynthetic process via alpha-aminoadipate and saccharopine + +[Term] +id: GO:2001197 +name: basement membrane assembly involved in embryonic body morphogenesis +namespace: biological_process +def: "Any basement membrane assembly that is involved in embryonic body morphogenesis." [GOC:obol] +is_a: GO:0010927 ! cellular component assembly involved in morphogenesis +is_a: GO:0070831 ! basement membrane assembly +relationship: part_of GO:0010172 ! embryonic body morphogenesis + +[Term] +id: GO:2001198 +name: regulation of dendritic cell differentiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] +is_a: GO:1902105 ! regulation of leukocyte differentiation +relationship: regulates GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:2001199 +name: negative regulation of dendritic cell differentiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] +is_a: GO:1902106 ! negative regulation of leukocyte differentiation +is_a: GO:2001198 ! regulation of dendritic cell differentiation +relationship: negatively_regulates GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:2001200 +name: positive regulation of dendritic cell differentiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation." [GOC:obol] +is_a: GO:1902107 ! positive regulation of leukocyte differentiation +is_a: GO:2001198 ! regulation of dendritic cell differentiation +relationship: positively_regulates GO:0097028 ! dendritic cell differentiation + +[Term] +id: GO:2001204 +name: regulation of osteoclast development +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of osteoclast development." [GOC:obol] +synonym: "regulation of osteoclast cell development" EXACT [GOC:obol] +is_a: GO:0060284 ! regulation of cell development +relationship: regulates GO:0036035 ! osteoclast development + +[Term] +id: GO:2001205 +name: negative regulation of osteoclast development +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development." [GOC:obol] +synonym: "negative regulation of osteoclast cell development" EXACT [GOC:obol] +is_a: GO:0010721 ! negative regulation of cell development +is_a: GO:0045671 ! negative regulation of osteoclast differentiation +is_a: GO:2001204 ! regulation of osteoclast development +relationship: negatively_regulates GO:0036035 ! osteoclast development + +[Term] +id: GO:2001206 +name: positive regulation of osteoclast development +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of osteoclast development." [GOC:obol] +synonym: "positive regulation of osteoclast cell development" EXACT [GOC:obol] +is_a: GO:0010720 ! positive regulation of cell development +is_a: GO:0045672 ! positive regulation of osteoclast differentiation +is_a: GO:2001204 ! regulation of osteoclast development +relationship: positively_regulates GO:0036035 ! osteoclast development + +[Term] +id: GO:2001207 +name: regulation of transcription elongation from RNA polymerase I promoter +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458] +synonym: "regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] +is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation +relationship: regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter + +[Term] +id: GO:2001208 +name: negative regulation of transcription elongation by RNA polymerase I +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I." [PMID:20299458] +synonym: "negative regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] +synonym: "negative regulation of transcription elongation from RNA polymerase I promoter" EXACT [] +is_a: GO:0016479 ! negative regulation of transcription by RNA polymerase I +is_a: GO:0032785 ! negative regulation of DNA-templated transcription, elongation +is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter +relationship: negatively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter + +[Term] +id: GO:2001209 +name: positive regulation of transcription elongation from RNA polymerase I promoter +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter." [PMID:20299458] +synonym: "positive regulation of RNA elongation from Pol I promoter" EXACT [GOC:obol] +is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation +is_a: GO:0045943 ! positive regulation of transcription by RNA polymerase I +is_a: GO:2001207 ! regulation of transcription elongation from RNA polymerase I promoter +relationship: positively_regulates GO:0006362 ! transcription elongation from RNA polymerase I promoter + +[Term] +id: GO:2001210 +name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al] +synonym: "regulation of Ac-MVA pathway" EXACT [GOC:obol] +synonym: "regulation of acetate-mevalonate pathway" EXACT [GOC:obol] +synonym: "regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol] +synonym: "regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol] +synonym: "regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol] +is_a: GO:0019747 ! regulation of isoprenoid metabolic process +is_a: GO:0034248 ! regulation of cellular amide metabolic process +is_a: GO:0042762 ! regulation of sulfur metabolic process +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +is_a: GO:1900542 ! regulation of purine nucleotide metabolic process +relationship: regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway + +[Term] +id: GO:2001211 +name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway." [GOC:al] +synonym: "negative regulation of Ac-MVA pathway" EXACT [GOC:obol] +synonym: "negative regulation of acetate-mevalonate pathway" EXACT [GOC:obol] +synonym: "negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [GOC:obol] +synonym: "negative regulation of isopentenyl diphosphate formation, mevalonate pathway" EXACT [GOC:obol] +synonym: "negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [GOC:obol] +is_a: GO:0034249 ! negative regulation of cellular amide metabolic process +is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process +is_a: GO:0051175 ! negative regulation of sulfur metabolic process +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process +is_a: GO:2001210 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway +relationship: negatively_regulates GO:0019287 ! isopentenyl diphosphate biosynthetic process, mevalonate pathway + +[Term] +id: GO:2001212 +name: regulation of vasculogenesis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of vasculogenesis." [GOC:obol] +synonym: "regulation of vascular morphogenesis" EXACT [GOC:obol] +is_a: GO:0045595 ! regulation of cell differentiation +relationship: regulates GO:0001570 ! vasculogenesis + +[Term] +id: GO:2001213 +name: negative regulation of vasculogenesis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis." [GOC:obol] +synonym: "negative regulation of vascular morphogenesis" EXACT [GOC:obol] +is_a: GO:0045596 ! negative regulation of cell differentiation +is_a: GO:2001212 ! regulation of vasculogenesis +relationship: negatively_regulates GO:0001570 ! vasculogenesis + +[Term] +id: GO:2001214 +name: positive regulation of vasculogenesis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of vasculogenesis." [GOC:obol] +synonym: "positive regulation of vascular morphogenesis" EXACT [GOC:obol] +is_a: GO:0045597 ! positive regulation of cell differentiation +is_a: GO:2001212 ! regulation of vasculogenesis +relationship: positively_regulates GO:0001570 ! vasculogenesis + +[Term] +id: GO:2001215 +name: obsolete regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al] +comment: This term has been obsoleted because it represents a molecular function. +synonym: "regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol] +synonym: "regulation of HMG-CoA reductase activity" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0030234 +consider: GO:0106107 + +[Term] +id: GO:2001216 +name: obsolete negative regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of hydroxymethylglutaryl-CoA reductase (NADPH) activity." [GOC:al] +comment: This term has been obsoleted because it represents a molecular function. +synonym: "negative regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" RELATED [GOC:obol] +synonym: "negative regulation of HMG-CoA reductase activity" RELATED [GOC:obol] +is_obsolete: true +consider: GO:0004857 +consider: GO:0106108 + +[Term] +id: GO:2001217 +name: obsolete regulation of S/G2 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "regulation of S/G2 transition of mitotic cell cycle" EXACT [] +is_obsolete: true +consider: GO:0044770 + +[Term] +id: GO:2001218 +name: obsolete negative regulation of S/G2 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "negative regulation of S/G2 transition of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:2001219 +name: obsolete positive regulation of S/G2 transition of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of S/G2 transition of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "positive regulation of S/G2 transition of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:2001220 +name: obsolete negative regulation of G2 phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "negative regulation of G2 phase of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:2001221 +name: obsolete positive regulation of G2 phase of mitotic cell cycle +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:obol] +comment: This term was made obsolete because it does not refer to a real biological process. +synonym: "positive regulation of G2 phase of mitotic cell cycle" EXACT [] +is_obsolete: true + +[Term] +id: GO:2001222 +name: regulation of neuron migration +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of neuron migration." [GOC:obol] +synonym: "regulation of neuron chemotaxis" EXACT [GOC:obol] +synonym: "regulation of neuron guidance" RELATED [GOC:obol] +synonym: "regulation of neuronal migration" EXACT [GOC:obol] +is_a: GO:0030334 ! regulation of cell migration +relationship: regulates GO:0001764 ! neuron migration + +[Term] +id: GO:2001223 +name: negative regulation of neuron migration +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration." [GOC:obol] +synonym: "negative regulation of neuron chemotaxis" EXACT [GOC:obol] +synonym: "negative regulation of neuron guidance" RELATED [GOC:obol] +synonym: "negative regulation of neuronal migration" EXACT [GOC:obol] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:2001222 ! regulation of neuron migration +relationship: negatively_regulates GO:0001764 ! neuron migration + +[Term] +id: GO:2001224 +name: positive regulation of neuron migration +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of neuron migration." [GOC:obol] +synonym: "positive regulation of neuron chemotaxis" EXACT [GOC:obol] +synonym: "positive regulation of neuron guidance" RELATED [GOC:obol] +synonym: "positive regulation of neuronal migration" EXACT [GOC:obol] +is_a: GO:0030335 ! positive regulation of cell migration +is_a: GO:2001222 ! regulation of neuron migration +relationship: positively_regulates GO:0001764 ! neuron migration + +[Term] +id: GO:2001225 +name: regulation of chloride transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of chloride transport." [GOC:dph] +is_a: GO:0044070 ! regulation of anion transport +relationship: regulates GO:0006821 ! chloride transport + +[Term] +id: GO:2001226 +name: negative regulation of chloride transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport." [GOC:dph] +is_a: GO:1903792 ! negative regulation of anion transport +is_a: GO:2001225 ! regulation of chloride transport +relationship: negatively_regulates GO:0006821 ! chloride transport + +[Term] +id: GO:2001227 +name: quercitrin binding +namespace: molecular_function +def: "Binding to quercitrin." [GOC:obol] +is_a: GO:0043168 ! anion binding +is_a: GO:0097243 ! flavonoid binding +is_a: GO:0097367 ! carbohydrate derivative binding + +[Term] +id: GO:2001228 +name: regulation of response to gamma radiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of response to gamma radiation." [GOC:obol] +synonym: "regulation of response to gamma ray" RELATED [GOC:obol] +synonym: "regulation of response to gamma-ray photon" RELATED [GOC:obol] +is_a: GO:0048583 ! regulation of response to stimulus +relationship: regulates GO:0010332 ! response to gamma radiation + +[Term] +id: GO:2001229 +name: negative regulation of response to gamma radiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of response to gamma radiation." [GOC:obol] +synonym: "negative regulation of response to gamma ray" RELATED [GOC:obol] +synonym: "negative regulation of response to gamma-ray photon" RELATED [GOC:obol] +is_a: GO:0048585 ! negative regulation of response to stimulus +is_a: GO:2001228 ! regulation of response to gamma radiation +relationship: negatively_regulates GO:0010332 ! response to gamma radiation + +[Term] +id: GO:2001230 +name: positive regulation of response to gamma radiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of response to gamma radiation." [GOC:obol] +synonym: "positive regulation of response to gamma ray" RELATED [GOC:obol] +synonym: "positive regulation of response to gamma-ray photon" RELATED [GOC:obol] +is_a: GO:0048584 ! positive regulation of response to stimulus +is_a: GO:2001228 ! regulation of response to gamma radiation +relationship: positively_regulates GO:0010332 ! response to gamma radiation + +[Term] +id: GO:2001231 +name: regulation of protein localization to prospore membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah] +synonym: "regulation of protein localisation to prospore membrane" EXACT [] +synonym: "regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol] +synonym: "regulation of protein targeting to forespore membrane" RELATED [GOC:obol] +synonym: "regulation of protein targeting to FSM" RELATED [GOC:obol] +synonym: "regulation of protein targeting to prospore membrane" RELATED [] +synonym: "regulation of protein-prospore membrane targeting" RELATED [GOC:obol] +is_a: GO:1903076 ! regulation of protein localization to plasma membrane +relationship: regulates GO:1902657 ! protein localization to prospore membrane + +[Term] +id: GO:2001232 +name: positive regulation of protein localization to prospore membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane." [GOC:mah] +synonym: "positive regulation of protein localisation to prospore membrane" EXACT [] +synonym: "positive regulation of protein targeting to ascospore-type prospore membrane" RELATED [GOC:obol] +synonym: "positive regulation of protein targeting to forespore membrane" RELATED [GOC:obol] +synonym: "positive regulation of protein targeting to FSM" RELATED [GOC:obol] +synonym: "positive regulation of protein targeting to prospore membrane" RELATED [] +synonym: "positive regulation of protein-prospore membrane targeting" RELATED [GOC:obol] +is_a: GO:1903078 ! positive regulation of protein localization to plasma membrane +is_a: GO:2001231 ! regulation of protein localization to prospore membrane +relationship: positively_regulates GO:1902657 ! protein localization to prospore membrane + +[Term] +id: GO:2001233 +name: regulation of apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "regulation of apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:0009966 ! regulation of signal transduction +is_a: GO:0042981 ! regulation of apoptotic process +relationship: regulates GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:2001234 +name: negative regulation of apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "negative regulation of apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:0043066 ! negative regulation of apoptotic process +is_a: GO:2001233 ! regulation of apoptotic signaling pathway +relationship: negatively_regulates GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:2001235 +name: positive regulation of apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "positive regulation of apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:0043065 ! positive regulation of apoptotic process +is_a: GO:2001233 ! regulation of apoptotic signaling pathway +relationship: positively_regulates GO:0097190 ! apoptotic signaling pathway + +[Term] +id: GO:2001236 +name: regulation of extrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "regulation of extrinsic apoptosis" NARROW [] +synonym: "regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:2001233 ! regulation of apoptotic signaling pathway +relationship: regulates GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:2001237 +name: negative regulation of extrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "negative regulation of extrinsic apoptosis" NARROW [] +synonym: "negative regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:2001238 +name: positive regulation of extrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "positive regulation of extrinsic apoptosis" NARROW [] +synonym: "positive regulation of extrinsic apoptotic signalling pathway" EXACT [GOC:mah] +is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway +is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0097191 ! extrinsic apoptotic signaling pathway + +[Term] +id: GO:2001239 +name: regulation of extrinsic apoptotic signaling pathway in absence of ligand +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] +synonym: "regulation of dependence receptor signaling pathway" RELATED [GOC:obol] +synonym: "regulation of extrinsic apoptosis in absence of ligand" NARROW [] +synonym: "regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] +is_a: GO:2001236 ! regulation of extrinsic apoptotic signaling pathway +relationship: regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand + +[Term] +id: GO:2001240 +name: negative regulation of extrinsic apoptotic signaling pathway in absence of ligand +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] +synonym: "negative regulation of dependence receptor signaling pathway" RELATED [GOC:obol] +synonym: "negative regulation of extrinsic apoptosis in absence of ligand" NARROW [] +synonym: "negative regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] +is_a: GO:1901099 ! negative regulation of signal transduction in absence of ligand +is_a: GO:2001237 ! negative regulation of extrinsic apoptotic signaling pathway +is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand +relationship: negatively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand + +[Term] +id: GO:2001241 +name: positive regulation of extrinsic apoptotic signaling pathway in absence of ligand +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand." [GOC:mtg_apoptosis] +synonym: "positive regulation of dependence receptor signaling pathway" RELATED [GOC:obol] +synonym: "positive regulation of extrinsic apoptosis in absence of ligand" NARROW [] +synonym: "positive regulation of extrinsic apoptotic signalling pathway in absence of ligand" EXACT [GOC:mah] +is_a: GO:2001238 ! positive regulation of extrinsic apoptotic signaling pathway +is_a: GO:2001239 ! regulation of extrinsic apoptotic signaling pathway in absence of ligand +relationship: positively_regulates GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand + +[Term] +id: GO:2001242 +name: regulation of intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "regulation of intrinsic apoptosis" NARROW [] +synonym: "regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] +synonym: "regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] +is_a: GO:1902531 ! regulation of intracellular signal transduction +is_a: GO:2001233 ! regulation of apoptotic signaling pathway +relationship: regulates GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:2001243 +name: negative regulation of intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "negative regulation of intrinsic apoptosis" NARROW [] +synonym: "negative regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] +synonym: "negative regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] +is_a: GO:1902532 ! negative regulation of intracellular signal transduction +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: negatively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:2001244 +name: positive regulation of intrinsic apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "positive regulation of intrinsic apoptosis" NARROW [] +synonym: "positive regulation of intrinsic apoptotic pathway" EXACT [GOC:obol] +synonym: "positive regulation of intrinsic apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of mitochondrial-mediated apoptotic pathway" EXACT [GOC:obol] +is_a: GO:1902533 ! positive regulation of intracellular signal transduction +is_a: GO:2001235 ! positive regulation of apoptotic signaling pathway +is_a: GO:2001242 ! regulation of intrinsic apoptotic signaling pathway +relationship: positively_regulates GO:0097193 ! intrinsic apoptotic signaling pathway + +[Term] +id: GO:2001245 +name: regulation of phosphatidylcholine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] +synonym: "regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] +synonym: "regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] +synonym: "regulation of phosphatidylcholine formation" EXACT [GOC:obol] +synonym: "regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] +is_a: GO:0071071 ! regulation of phospholipid biosynthetic process +is_a: GO:0150172 ! regulation of phosphatidylcholine metabolic process +relationship: regulates GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:2001246 +name: negative regulation of phosphatidylcholine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] +synonym: "negative regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] +synonym: "negative regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of phosphatidylcholine formation" EXACT [GOC:obol] +synonym: "negative regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] +is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process +is_a: GO:0150174 ! negative regulation of phosphatidylcholine metabolic process +is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process +relationship: negatively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:2001247 +name: positive regulation of phosphatidylcholine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of phosphatidylcholine biosynthetic process." [GOC:obol] +synonym: "positive regulation of phosphatidylcholine anabolism" EXACT [GOC:obol] +synonym: "positive regulation of phosphatidylcholine biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of phosphatidylcholine formation" EXACT [GOC:obol] +synonym: "positive regulation of phosphatidylcholine synthesis" EXACT [GOC:obol] +is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process +is_a: GO:0150173 ! positive regulation of phosphatidylcholine metabolic process +is_a: GO:2001245 ! regulation of phosphatidylcholine biosynthetic process +relationship: positively_regulates GO:0006656 ! phosphatidylcholine biosynthetic process + +[Term] +id: GO:2001248 +name: regulation of ammonia assimilation cycle +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] +synonym: "regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] +synonym: "regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] +is_a: GO:0006808 ! regulation of nitrogen utilization +is_a: GO:2000211 ! regulation of glutamate metabolic process +relationship: regulates GO:0019676 ! ammonia assimilation cycle + +[Term] +id: GO:2001249 +name: negative regulation of ammonia assimilation cycle +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] +synonym: "negative regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] +synonym: "negative regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] +is_a: GO:0045847 ! negative regulation of nitrogen utilization +is_a: GO:2000212 ! negative regulation of glutamate metabolic process +is_a: GO:2001248 ! regulation of ammonia assimilation cycle +relationship: negatively_regulates GO:0019676 ! ammonia assimilation cycle + +[Term] +id: GO:2001250 +name: positive regulation of ammonia assimilation cycle +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of ammonia assimilation cycle." [GOC:BHF] +synonym: "positive regulation of glutamate metabolic process via glutamine and ammonia" EXACT [GOC:obol] +synonym: "positive regulation of glutamate metabolism via glutamine and ammonia" EXACT [GOC:obol] +is_a: GO:0045848 ! positive regulation of nitrogen utilization +is_a: GO:2000213 ! positive regulation of glutamate metabolic process +is_a: GO:2001248 ! regulation of ammonia assimilation cycle +relationship: positively_regulates GO:0019676 ! ammonia assimilation cycle + +[Term] +id: GO:2001251 +name: negative regulation of chromosome organization +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] +synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] +synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] +synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] +synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] +is_a: GO:0010639 ! negative regulation of organelle organization +is_a: GO:0033044 ! regulation of chromosome organization +relationship: negatively_regulates GO:0051276 ! chromosome organization + +[Term] +id: GO:2001252 +name: positive regulation of chromosome organization +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] +synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] +synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] +synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] +synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] +is_a: GO:0010638 ! positive regulation of organelle organization +is_a: GO:0033044 ! regulation of chromosome organization +relationship: positively_regulates GO:0051276 ! chromosome organization + +[Term] +id: GO:2001253 +name: regulation of histone H3-K36 trimethylation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] +is_a: GO:0000414 ! regulation of histone H3-K36 methylation +relationship: regulates GO:0097198 ! histone H3-K36 trimethylation + +[Term] +id: GO:2001254 +name: negative regulation of histone H3-K36 trimethylation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] +is_a: GO:0000415 ! negative regulation of histone H3-K36 methylation +is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation +relationship: negatively_regulates GO:0097198 ! histone H3-K36 trimethylation + +[Term] +id: GO:2001255 +name: positive regulation of histone H3-K36 trimethylation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of histone H3-K36 trimethylation." [PMID:17948059] +is_a: GO:0000416 ! positive regulation of histone H3-K36 methylation +is_a: GO:2001253 ! regulation of histone H3-K36 trimethylation +relationship: positively_regulates GO:0097198 ! histone H3-K36 trimethylation + +[Term] +id: GO:2001256 +name: regulation of store-operated calcium entry +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of store-operated calcium entry." [GOC:BHF] +synonym: "regulation of calcium ion import" RELATED [GOC:obol] +synonym: "regulation of capacitative calcium entry" EXACT [GOC:obol] +synonym: "regulation of SOCE" EXACT [GOC:obol] +synonym: "regulation of store-operated calcium import" EXACT [GOC:obol] +is_a: GO:0051924 ! regulation of calcium ion transport +relationship: regulates GO:0002115 ! store-operated calcium entry + +[Term] +id: GO:2001257 +name: regulation of cation channel activity +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cation channel activity." [GOC:BHF] +synonym: "regulation of cation diffusion facilitator activity" EXACT [GOC:obol] +synonym: "regulation of nonselective cation channel activity" EXACT [GOC:obol] +is_a: GO:0032412 ! regulation of ion transmembrane transporter activity +is_a: GO:1904062 ! regulation of cation transmembrane transport + +[Term] +id: GO:2001258 +name: negative regulation of cation channel activity +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity." [GOC:BHF] +synonym: "negative regulation of cation diffusion facilitator activity" EXACT [GOC:obol] +synonym: "negative regulation of nonselective cation channel activity" EXACT [GOC:obol] +is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity +is_a: GO:1904063 ! negative regulation of cation transmembrane transport +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:2001259 +name: positive regulation of cation channel activity +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cation channel activity." [GOC:BHF] +synonym: "positive regulation of cation diffusion facilitator activity" EXACT [GOC:obol] +synonym: "positive regulation of nonselective cation channel activity" EXACT [GOC:obol] +is_a: GO:0032414 ! positive regulation of ion transmembrane transporter activity +is_a: GO:1904064 ! positive regulation of cation transmembrane transport +is_a: GO:2001257 ! regulation of cation channel activity + +[Term] +id: GO:2001260 +name: regulation of semaphorin-plexin signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] +synonym: "regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] +is_a: GO:0009966 ! regulation of signal transduction +relationship: regulates GO:0071526 ! semaphorin-plexin signaling pathway + +[Term] +id: GO:2001261 +name: negative regulation of semaphorin-plexin signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] +synonym: "negative regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] +is_a: GO:0009968 ! negative regulation of signal transduction +is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway +relationship: negatively_regulates GO:0071526 ! semaphorin-plexin signaling pathway + +[Term] +id: GO:2001262 +name: positive regulation of semaphorin-plexin signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway." [GOC:BHF] +synonym: "positive regulation of semaphorin-plexin signalling pathway" EXACT [GOC:obol] +is_a: GO:0009967 ! positive regulation of signal transduction +is_a: GO:2001260 ! regulation of semaphorin-plexin signaling pathway +relationship: positively_regulates GO:0071526 ! semaphorin-plexin signaling pathway + +[Term] +id: GO:2001263 +name: regulation of C-C chemokine binding +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of C-C chemokine binding." [GOC:obol] +is_a: GO:0043393 ! regulation of protein binding + +[Term] +id: GO:2001264 +name: negative regulation of C-C chemokine binding +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of C-C chemokine binding." [GOC:obol] +is_a: GO:0032091 ! negative regulation of protein binding +is_a: GO:2001263 ! regulation of C-C chemokine binding + +[Term] +id: GO:2001265 +name: positive regulation of C-C chemokine binding +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of C-C chemokine binding." [GOC:obol] +is_a: GO:0032092 ! positive regulation of protein binding +is_a: GO:2001263 ! regulation of C-C chemokine binding + +[Term] +id: GO:2001266 +name: Roundabout signaling pathway involved in axon guidance +namespace: biological_process +def: "Any Roundabout signaling pathway that is involved in axon guidance." [GOC:bf, PMID:14527427, PMID:21820427] +synonym: "ROBO signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] +synonym: "ROBO signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] +synonym: "ROBO signaling pathway involved in axon guidance" EXACT [GOC:obol] +synonym: "ROBO signaling pathway involved in axon pathfinding" EXACT [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in axon guidance" EXACT [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in axon pathfinding" EXACT [GOC:obol] +synonym: "Roundabout signaling pathway involved in axon chemotaxis" RELATED [GOC:obol] +synonym: "Roundabout signaling pathway involved in axon growth cone guidance" RELATED [GOC:obol] +synonym: "Roundabout signaling pathway involved in axon pathfinding" EXACT [GOC:obol] +synonym: "Roundabout signalling pathway involved in axon chemotaxis" RELATED [GOC:obol] +synonym: "Roundabout signalling pathway involved in axon growth cone guidance" RELATED [GOC:obol] +synonym: "Roundabout signalling pathway involved in axon guidance" EXACT [GOC:obol] +synonym: "Roundabout signalling pathway involved in axon pathfinding" EXACT [GOC:obol] +is_a: GO:0035385 ! Roundabout signaling pathway +relationship: part_of GO:0007411 ! axon guidance + +[Term] +id: GO:2001267 +name: regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "regulation of initiator caspase activity" NARROW [GOC:obol] +is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:2001268 +name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "negative regulation of initiator caspase activity" NARROW [GOC:obol] +is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:2001234 ! negative regulation of apoptotic signaling pathway +is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway + +[Term] +id: GO:2001269 +name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway." [GOC:mtg_apoptosis] +synonym: "positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway" EXACT [GOC:mah] +synonym: "positive regulation of initiator caspase activity" NARROW [GOC:obol] +is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:2001267 ! regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway + +[Term] +id: GO:2001270 +name: regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] +synonym: "regulation of effector caspase activity" NARROW [GOC:obol] +is_a: GO:0043281 ! regulation of cysteine-type endopeptidase activity involved in apoptotic process + +[Term] +id: GO:2001271 +name: negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] +synonym: "negative regulation of effector caspase activity" NARROW [GOC:obol] +is_a: GO:0043154 ! negative regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:1900118 ! negative regulation of execution phase of apoptosis +is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis + +[Term] +id: GO:2001272 +name: positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis." [GOC:mtg_apoptosis] +synonym: "positive regulation of effector caspase activity" NARROW [GOC:obol] +is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process +is_a: GO:2001270 ! regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis + +[Term] +id: GO:2001273 +name: obsolete regulation of glucose import in response to insulin stimulus +namespace: biological_process +def: "OBSOLETE. Any process that modulates the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2001274 +name: obsolete negative regulation of glucose import in response to insulin stimulus +namespace: biological_process +def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] +synonym: "negative regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2001275 +name: obsolete positive regulation of glucose import in response to insulin stimulus +namespace: biological_process +def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus." [GOC:BHF] +comment: This term was obsoleted because it represents a GO-CAM model. +synonym: "positive regulation of cellular glucose import in response to insulin stimulus" EXACT [GOC:obol] +is_obsolete: true + +[Term] +id: GO:2001276 +name: regulation of leucine biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] +synonym: "regulation of leucine anabolism" EXACT [GOC:obol] +synonym: "regulation of leucine biosynthesis" EXACT [GOC:obol] +synonym: "regulation of leucine formation" EXACT [GOC:obol] +synonym: "regulation of leucine synthesis" EXACT [GOC:obol] +is_a: GO:2000282 ! regulation of cellular amino acid biosynthetic process +relationship: regulates GO:0009098 ! leucine biosynthetic process + +[Term] +id: GO:2001277 +name: negative regulation of leucine biosynthetic process +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] +synonym: "negative regulation of leucine anabolism" EXACT [GOC:obol] +synonym: "negative regulation of leucine biosynthesis" EXACT [GOC:obol] +synonym: "negative regulation of leucine formation" EXACT [GOC:obol] +synonym: "negative regulation of leucine synthesis" EXACT [GOC:obol] +is_a: GO:2000283 ! negative regulation of cellular amino acid biosynthetic process +is_a: GO:2001276 ! regulation of leucine biosynthetic process +relationship: negatively_regulates GO:0009098 ! leucine biosynthetic process + +[Term] +id: GO:2001278 +name: positive regulation of leucine biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of leucine biosynthetic process." [GOC:obol] +synonym: "positive regulation of leucine anabolism" EXACT [GOC:obol] +synonym: "positive regulation of leucine biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of leucine formation" EXACT [GOC:obol] +synonym: "positive regulation of leucine synthesis" EXACT [GOC:obol] +is_a: GO:2000284 ! positive regulation of cellular amino acid biosynthetic process +is_a: GO:2001276 ! regulation of leucine biosynthetic process +relationship: positively_regulates GO:0009098 ! leucine biosynthetic process + +[Term] +id: GO:2001279 +name: regulation of unsaturated fatty acid biosynthetic process +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636] +synonym: "regulation of fatty acid desaturation" RELATED [GOC:obol] +synonym: "regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol] +synonym: "regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol] +synonym: "regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol] +synonym: "regulation of unsaturated fatty acid formation" EXACT [GOC:obol] +synonym: "regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol] +is_a: GO:0042304 ! regulation of fatty acid biosynthetic process +relationship: regulates GO:0006636 ! unsaturated fatty acid biosynthetic process + +[Term] +id: GO:2001280 +name: positive regulation of unsaturated fatty acid biosynthetic process +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process." [GO:0006636] +synonym: "positive regulation of fatty acid desaturation" RELATED [GOC:obol] +synonym: "positive regulation of polyunsaturated fatty acid biosynthesis" RELATED [GOC:obol] +synonym: "positive regulation of unsaturated fatty acid anabolism" EXACT [GOC:obol] +synonym: "positive regulation of unsaturated fatty acid biosynthesis" EXACT [GOC:obol] +synonym: "positive regulation of unsaturated fatty acid formation" EXACT [GOC:obol] +synonym: "positive regulation of unsaturated fatty acid synthesis" EXACT [GOC:obol] +is_a: GO:0045723 ! positive regulation of fatty acid biosynthetic process +is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process +relationship: positively_regulates GO:0006636 ! unsaturated fatty acid biosynthetic process + +[Term] +id: GO:2001281 +name: regulation of muscle cell chemotaxis toward tendon cell +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of muscle cell chemotaxis toward tendon cell." [GOC:sart] +synonym: "regulation of muscle cell attraction" RELATED [GOC:obol] +synonym: "regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +is_a: GO:0030334 ! regulation of cell migration +is_a: GO:0050920 ! regulation of chemotaxis +relationship: regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell + +[Term] +id: GO:2001282 +name: negative regulation of muscle cell chemotaxis toward tendon cell +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of a muscle cell towards a tendon cell in response to an external stimulus. For example, when the muscle cell arrives at the target tendon cell, migration is arrested so that attachments can be made between the cells." [GOC:sart, PMID:19793885, PMID:20404543] +synonym: "arrest of muscle cell chemotaxis" NARROW [GOC:bf, GOC:sart, PMID:19793885] +synonym: "negative regulation of muscle cell attraction" RELATED [GOC:obol] +synonym: "negative regulation of muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +is_a: GO:0030336 ! negative regulation of cell migration +is_a: GO:0050922 ! negative regulation of chemotaxis +is_a: GO:2001281 ! regulation of muscle cell chemotaxis toward tendon cell +relationship: negatively_regulates GO:0036061 ! muscle cell chemotaxis toward tendon cell + +[Term] +id: GO:2001283 +name: Roundabout signaling pathway involved in muscle cell chemotaxis toward tendon cell +namespace: biological_process +def: "Any Roundabout signaling pathway that is involved in the directed movement of a muscle cell towards a tendon cell in response to an external stimulus." [GOC:bf, GOC:obol, GOC:sart, PMID:19793885] +synonym: "ROBO signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] +synonym: "ROBO signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] +synonym: "ROBO signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] +synonym: "ROBO/SLIT signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +synonym: "Roundabout signaling pathway involved in muscle cell attraction" RELATED [GOC:obol] +synonym: "Roundabout signaling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +synonym: "Roundabout signalling pathway involved in muscle cell attraction" RELATED [GOC:obol] +synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis toward tendon cell" EXACT [GOC:obol] +synonym: "Roundabout signalling pathway involved in muscle cell chemotaxis towards tendon cell" EXACT [GOC:obol] +is_a: GO:0035385 ! Roundabout signaling pathway +relationship: part_of GO:0036061 ! muscle cell chemotaxis toward tendon cell + +[Term] +id: GO:2001284 +name: regulation of BMP secretion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of BMP secretion." [GOC:sart] +synonym: "regulation of BMP protein secretion" EXACT [GOC:obol] +synonym: "regulation of bone morphogenetic protein secretion" EXACT [GOC:obol] +is_a: GO:0010646 ! regulation of cell communication +is_a: GO:0023051 ! regulation of signaling +is_a: GO:0050708 ! regulation of protein secretion +relationship: regulates GO:0038055 ! BMP secretion + +[Term] +id: GO:2001285 +name: negative regulation of BMP secretion +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion." [GOC:sart] +synonym: "negative regulation of BMP protein secretion" EXACT [GOC:obol] +synonym: "negative regulation of bone morphogenetic protein secretion" EXACT [GOC:obol] +is_a: GO:0010648 ! negative regulation of cell communication +is_a: GO:0023057 ! negative regulation of signaling +is_a: GO:0050709 ! negative regulation of protein secretion +is_a: GO:2001284 ! regulation of BMP secretion +relationship: negatively_regulates GO:0038055 ! BMP secretion + +[Term] +id: GO:2001286 +name: regulation of caveolin-mediated endocytosis +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] +synonym: "regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] +synonym: "regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] +synonym: "regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] +is_a: GO:0030100 ! regulation of endocytosis +relationship: regulates GO:0072584 ! caveolin-mediated endocytosis + +[Term] +id: GO:2001287 +name: negative regulation of caveolin-mediated endocytosis +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] +synonym: "negative regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] +synonym: "negative regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] +synonym: "negative regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] +is_a: GO:0045806 ! negative regulation of endocytosis +is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis +relationship: negatively_regulates GO:0072584 ! caveolin-mediated endocytosis + +[Term] +id: GO:2001288 +name: positive regulation of caveolin-mediated endocytosis +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of caveolin-mediated endocytosis." [GOC:obol] +synonym: "positive regulation of caveolae-dependent endocytosis" EXACT [GOC:obol] +synonym: "positive regulation of caveolae-mediated endocytosis" EXACT [GOC:obol] +synonym: "positive regulation of caveolin-dependent endocytosis" EXACT [GOC:obol] +is_a: GO:0045807 ! positive regulation of endocytosis +is_a: GO:2001286 ! regulation of caveolin-mediated endocytosis +relationship: positively_regulates GO:0072584 ! caveolin-mediated endocytosis + +[Term] +id: GO:2001289 +name: lipid X metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipid X, 2,3-diacylglucosamine 1-phosphate." [GOC:obol] +synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol] +synonym: "2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol] +synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolic process" RELATED [GOC:obol] +synonym: "2,3-Bis(beta-hydoroxymyristoyl)-beta-D-glucosaminyl 1-phosphate metabolism" RELATED [GOC:obol] +synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolic process" EXACT [GOC:obol] +synonym: "2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism" EXACT [GOC:obol] +synonym: "lipid X metabolism" EXACT [GOC:obol] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0006796 ! phosphate-containing compound metabolic process +is_a: GO:0019637 ! organophosphate metabolic process + +[Term] +id: GO:2001290 +name: hydroperoxide metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a hydroperoxide." [GOC:rs, PMID:15917183, PMID:18084891] +synonym: "hydroperoxide metabolism" EXACT [GOC:obol] +is_a: GO:0044237 ! cellular metabolic process + +[Term] +id: GO:2001291 +name: codeine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf] +synonym: "codeine metabolism" EXACT [GOC:obol] +is_a: GO:0033076 ! isoquinoline alkaloid metabolic process +is_a: GO:1901376 ! organic heteropentacyclic compound metabolic process + +[Term] +id: GO:2001292 +name: codeine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of codeine, an alkaloid found in the opium poppy, Papaver somniferum var. album. Codeine has analgesic, anti-tussive and anti-diarrhoeal properties." [GOC:yaf, UniPathway:UPA00318] +synonym: "codeine breakdown" EXACT [GOC:obol] +synonym: "codeine catabolism" EXACT [GOC:obol] +synonym: "codeine degradation" EXACT [GOC:obol] +is_a: GO:0071274 ! isoquinoline alkaloid catabolic process +is_a: GO:1901377 ! organic heteropentacyclic compound catabolic process +is_a: GO:2001291 ! codeine metabolic process + +[Term] +id: GO:2001293 +name: malonyl-CoA metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf, PMID:11902724, PMID:15726818, PMID:18981598] +synonym: "malonyl-CoA metabolism" EXACT [GOC:obol] +is_a: GO:0006637 ! acyl-CoA metabolic process + +[Term] +id: GO:2001294 +name: malonyl-CoA catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf] +synonym: "malonyl-CoA breakdown" EXACT [GOC:obol] +synonym: "malonyl-CoA catabolism" EXACT [GOC:obol] +synonym: "malonyl-CoA degradation" EXACT [GOC:obol] +is_a: GO:0009154 ! purine ribonucleotide catabolic process +is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process +is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:2001293 ! malonyl-CoA metabolic process + +[Term] +id: GO:2001295 +name: malonyl-CoA biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A." [GOC:yaf, UniPathway:UPA00655] +synonym: "malonyl-CoA anabolism" EXACT [GOC:obol] +synonym: "malonyl-CoA biosynthesis" EXACT [GOC:obol] +synonym: "malonyl-CoA formation" EXACT [GOC:obol] +synonym: "malonyl-CoA synthesis" EXACT [GOC:obol] +is_a: GO:0071616 ! acyl-CoA biosynthetic process +is_a: GO:2001293 ! malonyl-CoA metabolic process + +[Term] +id: GO:2001296 +name: N(omega)-methyl-L-arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N(omega)-methyl-L-arginine." [GOC:rs, PMID:10510241] +synonym: "N(omega)-methyl-L-arginine metabolism" EXACT [GOC:obol] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:2001297 +name: N(omega)-methyl-L-arginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N(omega)-methyl-L-arginine." [GOC:rs, PMID:10510241] +synonym: "N(omega)-methyl-L-arginine breakdown" EXACT [GOC:obol] +synonym: "N(omega)-methyl-L-arginine catabolism" EXACT [GOC:obol] +synonym: "N(omega)-methyl-L-arginine degradation" EXACT [GOC:obol] +is_a: GO:0009063 ! cellular amino acid catabolic process +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process +is_a: GO:2001296 ! N(omega)-methyl-L-arginine metabolic process + +[Term] +id: GO:2001298 +name: N(omega),N(omega)-dimethyl-L-arginine metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [GOC:rs, PMID:10510241] +synonym: "N(omega),N(omega)-dimethyl-L-arginine metabolism" EXACT [GOC:obol] +is_a: GO:0006575 ! cellular modified amino acid metabolic process +is_a: GO:1901605 ! alpha-amino acid metabolic process + +[Term] +id: GO:2001299 +name: N(omega),N(omega)-dimethyl-L-arginine catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of N(omega),N(omega)-dimethyl-L-arginine, a methyl-L-arginine having two methyl groups both attached to the primary amino moiety of the guanidino group." [GOC:rs, PMID:10510241] +synonym: "N(omega),N(omega)-dimethyl-L-arginine breakdown" EXACT [GOC:obol] +synonym: "N(omega),N(omega)-dimethyl-L-arginine catabolism" EXACT [GOC:obol] +synonym: "N(omega),N(omega)-dimethyl-L-arginine degradation" EXACT [GOC:obol] +is_a: GO:0042219 ! cellular modified amino acid catabolic process +is_a: GO:1901606 ! alpha-amino acid catabolic process +is_a: GO:2001298 ! N(omega),N(omega)-dimethyl-L-arginine metabolic process + +[Term] +id: GO:2001300 +name: lipoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [GOC:mw] +synonym: "lipoxin metabolism" EXACT [GOC:obol] +is_a: GO:1901568 ! fatty acid derivative metabolic process + +[Term] +id: GO:2001301 +name: lipoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signalling molecule that has four conjugated double bonds and is derived from arachidonic acid." [GOC:mw] +synonym: "lipoxin anabolism" EXACT [GOC:obol] +synonym: "lipoxin biosynthesis" EXACT [GOC:obol] +synonym: "lipoxin formation" EXACT [GOC:obol] +synonym: "lipoxin synthesis" EXACT [GOC:obol] +is_a: GO:1901570 ! fatty acid derivative biosynthetic process +is_a: GO:2001300 ! lipoxin metabolic process + +[Term] +id: GO:2001302 +name: lipoxin A4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [GOC:mw] +synonym: "lipoxin A4 metabolism" EXACT [GOC:obol] +synonym: "LXA4 metabolic process" EXACT [GOC:obol] +synonym: "LXA4 metabolism" EXACT [GOC:obol] +is_a: GO:0033559 ! unsaturated fatty acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +is_a: GO:2001300 ! lipoxin metabolic process + +[Term] +id: GO:2001303 +name: lipoxin A4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipoxin A4. Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds." [GOC:mw] +synonym: "lipoxin A4 anabolism" EXACT [GOC:obol] +synonym: "lipoxin A4 biosynthesis" EXACT [GOC:obol] +synonym: "lipoxin A4 formation" EXACT [GOC:obol] +synonym: "lipoxin A4 synthesis" EXACT [GOC:obol] +synonym: "LXA4 anabolism" EXACT [GOC:obol] +synonym: "LXA4 biosynthesis" EXACT [GOC:obol] +synonym: "LXA4 biosynthetic process" EXACT [GOC:obol] +synonym: "LXA4 formation" EXACT [GOC:obol] +synonym: "LXA4 synthesis" EXACT [GOC:obol] +is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:2001301 ! lipoxin biosynthetic process +is_a: GO:2001302 ! lipoxin A4 metabolic process + +[Term] +id: GO:2001304 +name: lipoxin B4 metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [GOC:mw] +synonym: "lipoxin B4 metabolism" EXACT [GOC:obol] +synonym: "LXB4 metabolic process" EXACT [GOC:obol] +synonym: "LXB4 metabolism" EXACT [GOC:obol] +is_a: GO:0033559 ! unsaturated fatty acid metabolic process +is_a: GO:1901615 ! organic hydroxy compound metabolic process +is_a: GO:2001300 ! lipoxin metabolic process + +[Term] +id: GO:2001305 +name: xanthone-containing compound metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a xanthone-containing compound." [GOC:di] +synonym: "xanthone metabolism" NARROW [CHEBI:37647] +synonym: "xanthone-containing compound metabolism" EXACT [GOC:obol] +synonym: "xanthones metabolic process" EXACT [GOC:obol] +synonym: "xanthones metabolism" EXACT [GOC:obol] +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:2001306 +name: lipoxin B4 biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of lipoxin B4. Lipoxin B4 is a C20 hydroxy fatty acid having (5S)-, (14R)- and (15S)-hydroxy groups as well as (6E)- (8Z)-, (10E)- and (12E)-double bonds." [GOC:mw] +synonym: "lipoxin B4 anabolism" EXACT [GOC:obol] +synonym: "lipoxin B4 biosynthesis" EXACT [GOC:obol] +synonym: "lipoxin B4 formation" EXACT [GOC:obol] +synonym: "lipoxin B4 synthesis" EXACT [GOC:obol] +synonym: "LXB4 anabolism" EXACT [GOC:obol] +synonym: "LXB4 biosynthesis" EXACT [GOC:obol] +synonym: "LXB4 biosynthetic process" EXACT [GOC:obol] +synonym: "LXB4 formation" EXACT [GOC:obol] +synonym: "LXB4 synthesis" EXACT [GOC:obol] +is_a: GO:0006636 ! unsaturated fatty acid biosynthetic process +is_a: GO:1901617 ! organic hydroxy compound biosynthetic process +is_a: GO:2001301 ! lipoxin biosynthetic process +is_a: GO:2001304 ! lipoxin B4 metabolic process + +[Term] +id: GO:2001307 +name: xanthone-containing compound biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a xanthone-containing compound." [GOC:di] +synonym: "xanthone biosynthesis" NARROW [CHEBI:37647] +synonym: "xanthone biosynthetic process" NARROW [CHEBI:37647] +synonym: "xanthone-containing compound anabolism" EXACT [GOC:obol] +synonym: "xanthone-containing compound biosynthesis" EXACT [GOC:obol] +synonym: "xanthone-containing compound formation" EXACT [GOC:obol] +synonym: "xanthone-containing compound synthesis" EXACT [GOC:obol] +synonym: "xanthones anabolism" EXACT [GOC:obol] +synonym: "xanthones biosynthesis" EXACT [GOC:obol] +synonym: "xanthones biosynthetic process" EXACT [GOC:obol] +synonym: "xanthones formation" EXACT [GOC:obol] +synonym: "xanthones synthesis" EXACT [GOC:obol] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:2001305 ! xanthone-containing compound metabolic process + +[Term] +id: GO:2001308 +name: gliotoxin metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [PMID:16333108, PMID:17574915, PMID:18272357] +synonym: "gliotoxin metabolism" EXACT [GOC:obol] +is_a: GO:0006518 ! peptide metabolic process +is_a: GO:0006790 ! sulfur compound metabolic process +is_a: GO:0043385 ! mycotoxin metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:2001309 +name: gliotoxin catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357] +synonym: "gliotoxin breakdown" EXACT [GOC:obol] +synonym: "gliotoxin catabolism" EXACT [GOC:obol] +synonym: "gliotoxin degradation" EXACT [GOC:obol] +is_a: GO:0043171 ! peptide catabolic process +is_a: GO:0043387 ! mycotoxin catabolic process +is_a: GO:0044273 ! sulfur compound catabolic process +is_a: GO:0046700 ! heterocycle catabolic process +is_a: GO:0051410 ! detoxification of nitrogen compound +is_a: GO:1901361 ! organic cyclic compound catabolic process +is_a: GO:2001308 ! gliotoxin metabolic process + +[Term] +id: GO:2001310 +name: gliotoxin biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi." [GOC:di, PMID:16333108, PMID:17574915, PMID:18272357, PMID:29966253] +synonym: "gliotoxin anabolism" EXACT [GOC:obol] +synonym: "gliotoxin biosynthesis" EXACT [GOC:obol] +synonym: "gliotoxin formation" EXACT [GOC:obol] +synonym: "gliotoxin synthesis" EXACT [GOC:obol] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0043043 ! peptide biosynthetic process +is_a: GO:0043386 ! mycotoxin biosynthetic process +is_a: GO:0044272 ! sulfur compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:2001308 ! gliotoxin metabolic process + +[Term] +id: GO:2001311 +name: lysobisphosphatidic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolic process" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) metabolism" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate metabolic process" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate metabolism" EXACT [GOC:obol] +synonym: "LBPA metabolic process" EXACT [GOC:obol] +synonym: "LBPA metabolism" EXACT [GOC:obol] +synonym: "lysobisphosphatidic acid metabolism" EXACT [GOC:obol] +is_a: GO:0006650 ! glycerophospholipid metabolic process +is_a: GO:0052646 ! alditol phosphate metabolic process + +[Term] +id: GO:2001312 +name: lysobisphosphatidic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a lysobisphosphatidic acid. A lysobisphosphatidic acid is a lysophosphatidic acid having the unusual property of a phosphodiester moiety linked to positions sn-1 and sn1' of glycerol; and two additional fatty acids esterified to the glycerol head group." [GOC:mw] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) anabolism" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthesis" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) biosynthetic process" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) formation" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate (BMP) synthesis" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate anabolism" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthesis" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate biosynthetic process" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate formation" EXACT [GOC:obol] +synonym: "bis(monoacylglycerol) hydrogen phosphate synthesis" EXACT [GOC:obol] +synonym: "LBPA anabolism" EXACT [GOC:obol] +synonym: "LBPA biosynthesis" EXACT [GOC:obol] +synonym: "LBPA biosynthetic process" EXACT [GOC:obol] +synonym: "LBPA formation" EXACT [GOC:obol] +synonym: "LBPA synthesis" EXACT [GOC:obol] +synonym: "lysobisphosphatidic acid anabolism" EXACT [GOC:obol] +synonym: "lysobisphosphatidic acid biosynthesis" EXACT [GOC:obol] +synonym: "lysobisphosphatidic acid formation" EXACT [GOC:obol] +synonym: "lysobisphosphatidic acid synthesis" EXACT [GOC:obol] +is_a: GO:0046474 ! glycerophospholipid biosynthetic process +is_a: GO:1901137 ! carbohydrate derivative biosynthetic process +is_a: GO:2001311 ! lysobisphosphatidic acid metabolic process + +[Term] +id: GO:2001313 +name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolism" EXACT [GOC:obol] +is_a: GO:0006040 ! amino sugar metabolic process +is_a: GO:0006793 ! phosphorus metabolic process +is_a: GO:0009225 ! nucleotide-sugar metabolic process + +[Term] +id: GO:2001314 +name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose breakdown" EXACT [GOC:obol] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose catabolism" EXACT [GOC:obol] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose degradation" EXACT [GOC:obol] +is_a: GO:0009227 ! nucleotide-sugar catabolic process +is_a: GO:0046348 ! amino sugar catabolic process +is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process + +[Term] +id: GO:2001315 +name: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose." [GOC:yaf, UniPathway:UPA00032] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose anabolism" EXACT [GOC:obol] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthesis" EXACT [GOC:obol] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose formation" EXACT [GOC:obol] +synonym: "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose synthesis" EXACT [GOC:obol] +is_a: GO:0009226 ! nucleotide-sugar biosynthetic process +is_a: GO:0046349 ! amino sugar biosynthetic process +is_a: GO:2001313 ! UDP-4-deoxy-4-formamido-beta-L-arabinopyranose metabolic process + +[Term] +id: GO:2001316 +name: kojic acid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving kojic acid." [GOC:di] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolic process" EXACT [GOC:obol] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one metabolism" EXACT [GOC:obol] +synonym: "C6H6O4 metabolic process" RELATED [GOC:obol] +synonym: "C6H6O4 metabolism" RELATED [GOC:obol] +synonym: "kojic acid metabolism" EXACT [GOC:obol] +is_a: GO:0034308 ! primary alcohol metabolic process +is_a: GO:0042180 ! cellular ketone metabolic process +is_a: GO:0046483 ! heterocycle metabolic process +is_a: GO:0120254 ! olefinic compound metabolic process +is_a: GO:1901360 ! organic cyclic compound metabolic process + +[Term] +id: GO:2001317 +name: kojic acid biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of kojic acid." [GOC:di] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one anabolism" EXACT [GOC:obol] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthesis" EXACT [GOC:obol] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one biosynthetic process" EXACT [GOC:obol] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one formation" EXACT [GOC:obol] +synonym: "5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one synthesis" EXACT [GOC:obol] +synonym: "C6H6O4 anabolism" RELATED [GOC:obol] +synonym: "C6H6O4 biosynthesis" RELATED [GOC:obol] +synonym: "C6H6O4 biosynthetic process" RELATED [GOC:obol] +synonym: "C6H6O4 formation" RELATED [GOC:obol] +synonym: "C6H6O4 synthesis" RELATED [GOC:obol] +synonym: "kojic acid anabolism" EXACT [GOC:obol] +synonym: "kojic acid biosynthesis" EXACT [GOC:obol] +synonym: "kojic acid formation" EXACT [GOC:obol] +synonym: "kojic acid synthesis" EXACT [GOC:obol] +is_a: GO:0018130 ! heterocycle biosynthetic process +is_a: GO:0034309 ! primary alcohol biosynthetic process +is_a: GO:0042181 ! ketone biosynthetic process +is_a: GO:0120255 ! olefinic compound biosynthetic process +is_a: GO:1901362 ! organic cyclic compound biosynthetic process +is_a: GO:2001316 ! kojic acid metabolic process + +[Typedef] +id: negatively_regulates +name: negatively regulates +namespace: external +xref: RO:0002212 +is_a: regulates ! regulates + +[Typedef] +id: part_of +name: part of +namespace: external +xref: BFO:0000050 +is_transitive: true + +[Typedef] +id: positively_regulates +name: positively regulates +namespace: external +xref: RO:0002213 +holds_over_chain: negatively_regulates negatively_regulates +is_a: regulates ! regulates + +[Typedef] +id: regulates +name: regulates +namespace: external +xref: RO:0002211 +is_transitive: true + +[Typedef] +id: term_tracker_item +name: term tracker item +namespace: external +xref: IAO:0000233 +is_metadata_tag: true +is_class_level: true + diff --git a/minerva-core/src/test/resources/test-complement-roots.ttl b/minerva-core/src/test/resources/test-complement-roots.ttl new file mode 100644 index 00000000..d2c6a498 --- /dev/null +++ b/minerva-core/src/test/resources/test-complement-roots.ttl @@ -0,0 +1,70 @@ +@prefix : . +@prefix owl: . +@prefix rdf: . +@prefix xml: . +@prefix xsd: . +@prefix rdfs: . +@base . + + rdf:type owl:Ontology ; + owl:versionIRI ; + "development" ; + "https://orcid.org/0000-0002-8688-6599"^^xsd:string ; + "2022-01-28"^^xsd:string ; + "http://geneontology.org"^^xsd:string . + +################################################################# +# Annotation properties +################################################################# + +### http://geneontology.org/lego/modelstate + rdf:type owl:AnnotationProperty . + + +### http://purl.org/dc/elements/1.1/contributor + rdf:type owl:AnnotationProperty . + + +### http://purl.org/dc/elements/1.1/date + rdf:type owl:AnnotationProperty . + + +### http://purl.org/pav/providedBy + rdf:type owl:AnnotationProperty . + + +################################################################# +# Classes +################################################################# + +### http://purl.obolibrary.org/obo/GO_0007267 + rdf:type owl:Class . + + +### http://purl.obolibrary.org/obo/GO_0010737 + rdf:type owl:Class . + + +################################################################# +# Individuals +################################################################# + +### http://model.geneontology.org/61f3310500000003/61f3310500000004 + rdf:type owl:NamedIndividual , + ; + "https://orcid.org/0000-0002-8688-6599"^^xsd:string ; + "2022-01-28"^^xsd:string ; + "http://geneontology.org"^^xsd:string . + + +### http://model.geneontology.org/61f3310500000003/61f3310500000005 + rdf:type owl:NamedIndividual , + [ rdf:type owl:Class ; + owl:complementOf + ] ; + "https://orcid.org/0000-0002-8688-6599"^^xsd:string ; + "2022-01-28"^^xsd:string ; + "http://geneontology.org"^^xsd:string . + + +### Generated by the OWL API (version 4.5.15) https://github.com/owlcs/owlapi